bluuebunny/crossref_metadata_2025 huggingface dataset:
Result MarkeT Model and Railway Truck Transport Technology
Authors: Kuziev Ihor
Published: March 2023

The processes of liberalization, the attempt to transition the railway industry to a new market model of free competition without corresponding changes in the component model negatively affect the efficiency of the railway industry and the effectiveness of the freight railway service market. It is proposed to look at the problem not from the standpoint of changing the form of ownership in the industry and the formation of a free competition market, but from the standpoint of finding a balance between the work technology and the model of the freight rail transport market that is being used. The study is based on the well-known concept of Industrial organization. The author considers the market as a living mechanism that responds to changes in its components within its field, not only as a place for concluding deals. The effectiveness of the rail freight transport market largely depends on the technology of creating a rail freight service. It is proposed to form a market model based not so much on the appearance of competition, but on some harmony of the technology of freight railway service and the market, or rather the balance of the components of the service market. The goal is to define a model of an effective rail freight market, in which the railway industry will be able to show maximum efficiency. Work methods – expert assessment of an attempt to change the model of the freight rail transportation market; analysis of the reasons for the imbalance of the economic mechanism of transport activity in the field of freight rail transport; an attempt to structure the goals of an efficient rail freight market. Based on the results of the research, recommendations can be formulated regarding the formation of a balanced model of the market for freight rail transportation and the adjustment of goals and the existing market model.
Comparison of DNA Sequencing and Multispecific Monoclonal Antibody (Msmab-1) based Immunohistochemical Detection of IDH1/2 Mutation in Acute Myeloid Leukemia Cases.
Authors: Akanksha Agarwal  , Mili Jain  , Rashmi Kushwaha  , Shikha Tewari  , Seema Nayak  , Verma Nishant , Anil Kumar Tripathi  , Ashutosh Kumar
Published: March 2023

Background: The IDH1/2 mutation is an important epigenetic modifier involved in the pathogenesis of AML. It is associated with variable prognosis in AML cases. Lack of proper molecular diagnostic infrastructure and high cost limits the routine use of PCR with sequencing as routine diagnostic methodology. The aim of this study was to find the prevalence of IDH mutation in AML cases using both PCR with sequencing and Immunohistochemistry method.

Methods: We evaluated 60 patients registered at KGMU, Lucknow for diagnosis and treatment of AML. PCR followed by sequencing was done. IHC staining of the IDH1/2 mutation was performed on all cases using bone biopsy or clot section (in cases of pediatric AML cases).

Results: Out of the total 60 patients of AML 4(6.7%) patients had IDH1R312 mutation and 5(8.3%) Patients had IDH2R172 mutation. IDH2 R140 mutation was not detected in any sample. On immunohistochemistry analysis 10 cases showed positive staining against anti IDH1/2 mutant (R132/R172) antibody, clone MsMab-1 with a sensitivity of 77.8% and specificity of 94.1%.

Conclusion: IHC could be an alternative method to direct Sanger sequencing for IDH1/2 mutation detection in AML cases. However, the antibody used in the study is not effective for individual assessment of IDH1 and IDH2 mutation.

Keywords: Immunohistochemistry, Sanger sequencing, IDH1/2 Mutation, Acute Myeloid Leukemia
A Review on Solanum Virginianum (Solanaceae): Phytochemical and Pharmacological Properties
Authors: Sharma Taniya , Rattan Muskan , Monika Sharma Monika Sharma , Singh Karan , Meena Pradeep , Jangir Surbhi
Published: March 2023

Solanum virginianum L. (Syn.: Solanum xanthocarpum) Family, Solanaceae; also known as Yellow berried nightshade or Kantkari is one of the members of the dashmula (ten roots) of the Ayurveda. It is a very spiny diffuse herb up to 1.2 m tall, commonly found throughout India, used in medicine in various forms, such as decoction, electuary, ghrita, etc. It is utilized for the curing of fever, bronchial asthma and cough throughout Indian subcontinent since ancient times. Therefore, researchers have tested biological activities of extracts and pure compounds from different parts of this herb. A range of pharmacological effects, such as antiurolithiatic, antihepatotoxic, antioxidative and anti -hyperglycaemic was observed supporting its use in traditional medicine.

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ДЕРЖАВА ЯК СУБ’ЄКТ СОЦІАЛЬНОГО ПАРТНЕРСТВА
Authors: Куртакова Ганна Олександрівна
Published: March 2023

Анотація. Кризовий стан економіки загострив потребу суспільства у досягненні соціального балансу між найманими працівниками, власниками (роботодавцями) і державою. Світовий досвід переконливо засвідчує, що проблеми економіки і суспільного життя, в тому числі у сфері застосування найманої праці, вирішуються оптимально, якщо реалізується орієнтація не на конфронтацію, а на досягнення соціальної злагоди, узгодження інтересів різних суспільних груп. Стрижнем соціального партнерства є принцип співробітництва між роботодавцями і найманими працівниками, який реалізується шляхом проведення переговорів, укладення колективних договорів та колективних угод, узгодження проектів нормативно-правових актів, консультацій при прийнятті рішень соціальними партнерами на всіх рівнях. Соціальне партнерство базується на колективних відносинах між соціальними партнерами за участі трудових колективів у встановленні умов праці; в управлінні організаціями, де вони працюють; щодо укладення і виконання колективних договорів та колективних угод на галузевому, регіональному, національному рівнях; щодо діяльності професійних спілок та інших представницьких органів трудового колективу в соціально-трудових відносинах; щодо утворення та діяльності об’єднань роботодавців; у вирішенні індивідуальних та колективних трудових спорів. До сфери соціального партнерства належать: досягнення консенсусу з питань забезпечення зайнятості, створення додаткових робочих місць, організації оплачуваних громадських робіт, захисту населення від безробіття; застосування найманої праці з дотриманням техніки безпеки, вимог з охорони здоров’я працівників у процесі праці, оплати праці й забезпечення відтворювальної і стимулювальної функцій заробітної плати; забезпечення нормального режиму праці й відпочинку; забезпечення права працівників на участь в управлінні робочим процесом на підприємстві, в розподілі прибутку для забезпечення соціальної діяльності підприємства, у визначенні соціальних стандартів і встановленні їх мінімальних меж, у встановленні порядку проведення колективних переговорів, вирішенні колективних трудових спорів тощо.
Foliküler Kistli Holstein Irkı Düvelerde Ovsynch Protokolünün Gebelik Oranları Üzerine Etkisi
Authors: DURSUN Şükrü , KÖSE Mehmet , KIZIL Sedat Hamdi , BULUT Gaye , ÖZTÜRK Caner , ATLI Mehmet Osman , KARAŞAHİN Tahir
Published: March 2023

Bu çalışmada, foliküler kistli Holstein ırkı düvelerde Ovsynch programının tedavideki etkinliğini belirlemek amaçlan- dı. Özel bir süt sığırı işletmesinde, iki veya üç tohumlamadan sonra gebe kalmayan, sık düzensiz, uzun veya sürekli östrüs belirtileri gösteren 2018 yılında 19 baş, 2022 yılında 17 baş, toplam 36 baş Holstein ırkı düve on gün arayla ikişer kez rektal palpasyon (RP) ve ultrasonografi (USG) ile tekniğine uygun olarak muayene edildi. İkinci muayeneden sonra, korpus luteum (CL) yokluğunda, 25 mm'den büyük çapta folikül taşıyan düveler (2018 yılında 13, 2022 yılında 12 olmak üzere toplam 25), foliküler kist grubuna dahil edilirken, kalan (2018’de 6, 2022 ‘de 5) 11 düve kontrol grubu olarak ayrıldı. Her iki gruptaki düvelere Ovsynch protokolü uygulandı. Düveler aynı ortamda aynı rasyon ile beslendi. Düvelerin gebelik muayeneleri tohumlamadan 45 gün sonra RP ve USG ile yapıldı. Elde edilen verilerin istatistiksel analizinde SPSS hazır paket programı kullanıldı. Gebelik oranı foliküler kist grubunda %88.0 (22/25), kontrol grubunda %72.73 (8/11) olarak tespit edildi. Grupların gebelik oranları arasında anlamlı fark yoktu (P≥0.05). Sonuç olarak, Ovsynch protokolünün foliküler kisti olan düvelerde kullanılabileceği kanısına varıldı.
Analisis Penerapan Komunikasi Lintas Budaya dalam Perusahaan Multinasional (Suatu Telaah Pustaka)
Authors: Surya Egar , Barkah Cecep Safaatul , Sukoco Iwan , Auliana Lina
Published: March 2023

Artikel ini membahas kajian mendalam mengenai komunikasi lintas budaya pada praktiknya dalam perusahaan multinasional secara konseptual. Disusun dalam rangka mencari tahu bagaimana globalisasi membuat perusahaan-perusahaan multinasional semakin banyak beroperasi di berbagai negara, dihadapkan dengan segala dinamika dan permasalahan yang ada terkait komunikasi dan transfer informasi diantara SDM perusahaan dengan latar belakang budaya beragam. Artikel ini disusun menggunakan metode kajian literatur melalui jurnal, artikel ilmiah, serta terbitan lainnya seperti berita penunjang. Diperoleh hasil bahwa konsep komunikasi lintas budaya memiliki teori dimensi, hambatan atau permasalahan, serta bahwa orang-orang yang bekerja di bawah lingkungan multinasional perlu lebih liberal dalam memahami budaya yang berbeda untuk membuat organisasi tumbuh secara global. Disimpulkan,  perusahaan multinasional dapat mengurangi masalah ini salah satunya dengan melakukan proses akulturasi, serta menerapkan berbagai kebijakan dan strategi guna menghadapi tidak hanya dinamika secara internal tim perusahaan multinasional yang multikultur, namun juga dalam tantangan menghadapi projek transnasional dan operasi bisnis global.
Pengaruh Harga dan Merek terhadap Keputusan Pembelian Smartphone di Indramayu
Authors: Sikki Nurhaeni , Dewi Vimala
Published: March 2023

Penelitian ini bertutujuan untuk mengetahui seberapa besar pengaruh harga dan merek terhadap keputusan pembelian smarphone di Indramayu serta menganalisis bagaimana harga dan merek dapat mempengaruhi kepusan pembelian smartphone di Indramayu. Penelitian ini menggunakan metode penelitian kuantitatif dengan jenis penelitian asosiatif. Pengambilan sample yakni menggunakan probability sampling yaitu simple random sampling dengan sample berjumlah 385 orang. Teknik analisis data yakni analisis deskriptif dan regresi linear berganda. Berdasarkan hasil pengujian hipotesis yakni dengan menggunakan uji simultan mendapatkan hasil harga dan merek berpengaruh signifikan terhadap keputasan pembelian smartphone di Indramayu. Hal tersebut dapat dibuktikan dengan Fhitung (127,022) > Ftabel (3.02) dengan tingkat sig 0,00 < 0,05. Berdasarkan hasil pengujian secara parsial (uji-t) didapat hasil variable harga dan merek berpengaruh positif dan signifikan terhadap keputusan pembelian smartphone di Indramayu. Berdasarkan koefisien determinasi didapat bahwa korelasi harga dan merek sebesar 39,9% terhadap keputusan pembelian dan 60,1% dipengaruhi oleh faktor lain yang tidak diteliti oleh peneliti.
Customer Experience dan Brand Trust sebagai Variabel yang Mempengaruhi Customer Loyalty Konsumen ZALORA Indonesia
Authors: Fatoni Aris , Nurafifah Nurafifah
Published: March 2023

Penelitian ini bertujuan untuk mengetahui bagaimana customer experience dan brand trust mempengaruhi customer loyalty e-commerce Zalora Indonesia di wilayah DKI Jakarta. Pendekatan penelitian bersifat kuantitatif dengan metode survei. Sampel berjumlah 100 responden konsumen e-commerce Zalora Indonesia di Jakarta. Hasil penelitian menemukan bahwa customer experience dan brand trust secara simultan berpengaruh signifikan terhadap customer loyalty konsumen e- commerce Zalora Indonesia di wilayah DKI Jakarta.
PENGARUH KUALITAS PELAYANAN DAN KEPUASAN PELANGGAN TERHADAP LOYALITAS PELANGGAN PADA JASA PENGIRIMAN BARANG J&T EXSPRESS CIPADUNG KOTA BANDUNG
Authors: Anjani Riska Nur
Published: March 2023

Pelayanan yang bertujuan memperoleh kepuasan pelanggan bukanlah suatu hal mudah untuk dilakukan, terdapat masalah masalah dalam pengelolaan pelayanan sebuah perusahaan dan ketidakberhasilan memuaskan pelanggan yang biasa dihadapi baik oleh perusahaan maupun pelanggan yaitu berkaitan dengan mutu layanan yang diberikan sebuah perusahaan kepada pelanggannya. Agar dapat memenuhi kebutuhan akan layanan pengiriman barang yang semakin tinggi serta harapan pelanggan sebagai sasaran utamanya, J&T Express memerlukan pemahaman terhadap pelanggan. Penelitian ini bertujuan untuk mengetahui pengaruh kualitas pelayanan dan kepuasan pelanggan terhadap loyalitas pelanggan yang menggunakan jasa pengiriman barang J&T Express Cipadung Kota Bandung baik secara parsial maupun simultan. tujuan penelitian ini ditujukan untuk mengetahui seberapa besar pengaruh kualitas pelayanan dan kepuasan pelanggan terhadap loyalitas pelanggan. Penelitian ini menggunakan metode kuantitatif asosiatif dengan menggunakan teknik purposive sampling. Penelitian ini menggunakan analisis regresi linier berganda. Teknik pengujian yang dilakukan dalam penelitian ini yaitu uji validitas dan reliabilitas, dan teknik analisis data menggunakan uji asumsi klasik, uji F, uji t, dan koefisien determinasi. Setelah peneliti menganalisa permasalahan yang telah ditemukan mengenai pengaruh kualitas pelayanan terhadap variabel loyalitas pelanggan tidak terdapat pengaruh secara signifikan sedangkan pada variabel kepuasan pelanggan terhadap variabel loyalitas pelanggan berpengaruh secara signifikan.
The most common route of administration used during COVID-19
Authors: Mena Raid Khalil  , Ghaidaa S. Hameed  , Dalya Basil Hanna
Published: March 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the virus that caused the COVID-19 pandemic. Initial symptoms include fever, cough, and dyspnea. Symptoms include nausea, vomiting, and abdominal pain, GIT involvement is also possible. The COVID-19 outbreak has increased the need for alternative medicine administration routes, particularly in public places. Buccal, sublingual, and rectal administration are all considered transmucosal methods. They are self-administration options for non-invasive systemic distribution. In addition, they are great for use in palliative and end-of-life care because of their quick onset of action and decreased first-pass metabolism. A mucosal atomization device allows for the intranasal administration of a parenteral formulation through nasal spray. Rectal mucosal absorption is comparable to that of the oral route, making the rectal route an extremely versatile and useful method of drug administration for a wide variety of medications. Covid-19 illness is treated with a variety of drugs, including anti-malaria medication (hydroxychloroquine), glucocorticoids (dexamethasone), antibiotics (azithromycin), and antiviral medications (favipiravir). This article discusses the route of drug administration for COVID-19, as well as symptoms, treatments, and the various ways it can be spread
Financial Reporting Quality and Control System: A Mixed Approach Assessment
Authors: Kwanbo Mansur Lubabah , Ali Baba Esther , Akanet Solomon , Tanko Muhammad
Published: March 2023

Listed firms have been reported by regulators to be tangled in financial scandals that have made the quality of their financial reports doubtful due to inadequate control systems of risk assessment, monitoring, information and communication, control environment and control activity. This study examines the relationship between financial reporting quality and the internal control system of listed firms in Nigeria. The research relieda hybridixed approach that sourced primary and secondary data using a bilateral convergent paralleled mixed design. The research method adopted is the interpretive post-action multiple case study that employs reduction and multiple regression as its data analysis techniques. Comparatively, results from both sources of data indicate that internal control system components are determinants of financial reporting quality. One of the implications of the findings on practice is that having financial and accounting experts on the board of directors that uses such expertise on risk assessment inhibits not achieving reporting quality. The study concludes that risk assessment improves financial reporting quality and recommends more such experts on the board of Nigerian firms.
Moderator Effect of Audit Committee on Earnings Management and Board Diversity
Authors: Ibrahim Mohammed , Mohammed Nasir , Hamza Mohammed Abubakar
Published: March 2023

This study examined the effect of board diversity, audit committee and earnings management of oil and gas (o&g) companies listed in Nigeria stock exchange. Female directors and foreign directors served as proxies for board diversity, audit committee independence and meeting frequency were moderating variables to study possible discretionary accruals in earnings. Eleven o&g companies in Nigeria that were listed that had consistently produced audited yearly financial reports from 2009 to 2019 were employed to accomplish the study's goals. Regression models with fixed and random effects were utilised in the investigation. The outcome showed that earnings management and the board diversity of listed o&g companies in Nigeria was moderated by the audit committee. The findings suggested that Nigerian-listed oil and gas businesses should give a gender quota for female directors. It is advised that regulators consider the number of meetings that audit committees hold, as it is the members' intelligence to comprehend the financial ramifications of management decisions rather than meeting frequency that determines the monitoring of managers' opportunistic attitudes.
Possibilities of realization of Ukraine’s export potential on the world market
Authors: Stavytska Alla , Kovalenko Alisa
Published: March 2023

In the article, the author calculated and analyzed the dynamics of indicators of Ukraine's export potential for the period 2016–2021. The product structure of Ukraine's exports in 2021 was determined and the share of goods exports in Ukraine's GDP was calculated for 2016–2021, which provided an opportunity to summarize existing trends and to present certain practical proposals. It was established that, despite the crisis conditions of 2020–2022, the trends demonstrate the activation of Ukrainian exporters on the world markets, but the structure of trade in itself somewhat inhibits the processes, which is reflected by a negative indicator of trade turnover. It was determined that the possibilities of Ukraine's export potential demonstrate that in 2021, ferrous metals and grain products will account for larger sales volumes on foreign markets. It is noted that Ukraine's exports are growing faster than imports, and the country's high dependence on imports is a negative factor. It was established that Ukraine remains a raw material appendage. Therefore, from a strategic perspective, Ukraine aims to change this trend through the active development of industrial processing, which will change the shares exactly the opposite: to export 75% of finished products and services and only 25% of raw materials. It has been found that the impact on the opportunities of Ukraine's export potential is exerted by a complex of internal and external factors, which are of an acute problematic nature. Based on the results of the calculations, it was established that an urgent issue in order to expand the possibilities of realizing the export potential of Ukraine on world markets is the implementation of a balanced foreign economic policy of the state regarding the support of national producers, the stimulation of export-oriented products and increasing their competitiveness, bringing the legislative framework in the field of foreign economic activity to meet world standards. It was determined and proposed that to optimize the commodity structure of foreign trade, a strategic measure is the transition from a focus on raw material exports to the export of processed, processed or finished products with high added value, as well as supplementing the existing dominant export industries with other promising directions.
Stone Matrix Asphalt Performance with Glycerin Pitch as Asphalt Binder Extender
Authors: Sihombing Atmy Verani Rouly , Utami Retno , Somantri Andri Krisnandi , Febriansya Aditia , Sihombing Reza Phalevi , Mulyadi Agah Muhammad
Published: March 2023

This research aims to utilize glycerin pitch waste as an alternative asphalt binder (extender) in Stone Mastic Asphalt (SMA) mixture. Glycerin pitch (GP) is a by-product from crude glycerol refining process from the palm oil oleochemical industry. The research method was carried out by testing the chemical and physical characteristics of GP by comparing it to pen 60/70, then testing based on asphalt binder rheology and asphalt concrete characteristics. ANOVA statistical test and Tukey-Kramer statistical grouping test were used to know the significant use of GP in SMA mixture. The variations of GP content tested to pen 60/70 were 0%, 15% and 25% by weight, then used as a binder for the SMA mixture which was tested under asphalt content (Pb) conditions based on Marshall characteristic, immersion index and drain down. The test results show that GP has the potential as an asphalt extender, with a maximum content of 22% by weight of asphalt binder or with a ratio of 1 GP: 4 pen 60/70. The characteristics of the SMA mixture using pen 60/70 and GP as asphalt binder extender, under conditions of Pb = 7% produce SMA mixture that meets the specification. Statistically, in stability characteristics of SMA, GP has a significant effect on SMA + 22% GP mixture. In the immersion index, the use of GP has a significant effect on all type of mixture, while in the draindown characteristics has significant effect on the SMA+0% GP mixture.
Parity Generators for Nanocommunication Systems Using QCA Nanotechnology
Authors: Sharma Vijay Kumar
Published: March 2023

Quantum-dot cellular automata (QCA) nanotechnology has the capability to design highly-dense, ultra-low power, and high-speed digital circuits at ultra-deep sub-micron (ultra-DSM) level. QCA nanostructure provides a transistor-free operation that saves large energy dissipation as compared to the conventional metal oxide semiconductor field effect transistor (MOSFET) technology. In this paper, 3-input exclusive-OR (XOR) and exclusive-NOR (XNOR) gates are presented using QCA cells. XOR and XNOR (XOR-XNOR) gates are further utilized to design the 2-, 3-, 4-, and 5-bit even and odd parity generators. The QCA-based 3-input XNOR gate is constructed using only 10 QCA cells and two clock phases. The target of the presented designs is to use the minimum count of QCA cells in a simplistic way to form the higher bit-size parity generators. The comparative analyses for the different performance metrics are showing that the developed designs are performing well for the cell count, latency, area, and layout cost as compared to the existing designs. Energy dissipation for the designs is calculated to check the energy efficiency by using the QCA Designer-E and QCA Pro tools.
The EU and Its Southern Neighborhood Policy: Resilience in the Era of Science Diplomacy
Authors: Zane Šime Zane
Published: March 2023

The European Union science diplomacy toward the Southern Neighbourhood could take advantage of some compartments of diplomacy studies and literature on resilience to build on earlier scholarly accomplishments and avoid duplication of efforts. Structural diplomacy is the selected framework for dwelling on the intricacies and challenging aspects of the overall topic. Conceptually and policy-wise, complexities revolving around multifaceted meanings of resilience and the polyphony of terminology employed in the diplomacy studies represent contemporary legacies and a densely layered context for the launch of the European Science Diplomacy Agenda.
The influence of accounting understanding, perception of smes, and level of education on implementation of SAK EMKM
Authors: Sululing Siswadi , Naida Muhammad Rizaldy
Published: March 2023

This study aims to determine partially and simultaneously the influence of understanding of accounting, perceptions of MSME actors, and level education on the application of SAK EMKM. This type of research is quantitative research. The population and sampel used is Café Chemistry Coffee and Space in Banggai Regency, Central Sulawesi with a sample of 10 employees. The data collection methods used were questionnaires and interviews, while the data analysis method used was multiple linear regression analysis. Partial and simultaneous research findings show that understanding of accounting, perceptions of MSME actors and education levels have a siqnificant effect on the application of SAK EMKM. Meanwhile, the result of the test for the coefficient of determination shown that accounting understanding, perceptions of MSME actors, and education level have an effect of 72% on the application of SAK EMKM, the remaining 28% is explained by other variables not included in this study.
The problems of Illegal Online Loans based on the Victim's Perspective: A Case Study
Authors: Putri Poppy Amanda , Rinaldi Kasmanto
Published: March 2023

The problems of illegal online loan cases is detrimental to society and the government. Illegal online loans have easy procedures to attract and interest the public. In collecting illegal online loans, they commit terror, spread personal data, spread slander, and hoaxes via chat and telephone. There is no transparency from illegal online loan companies to victims regarding interest, making victims pay larger debts than the amount borrowed. This study aims to examine the role of the victim in the occurrence of crimes committed by these illegal online loans. This study uses a qualitative research method with Criminal Function Theory by Stephen Schafer as an analytical tool that explains the role of the victim. Collecting data using observation techniques, interviews, and documentation. Based on the research results, it was found that when borrowing, the victim initially did not know that the application was illegal. The behavior of victims who are late in paying debts stimulates perpetrators to commit crimes against victims. Victims also borrow back at illegal online loans even though they know the risks.
Using VOA news material through virtual small group discussion on the students’ reading comprehension for university level
Authors: Ningsih Wirda , Zalisman Zalisman
Published: March 2023

This study aims to determine the effect of using VoA News material through Virtual Small Group discussions on students' reading comprehension at the university level. It was carried out by using a quasi-experimental design. The population of this research was the second semester of PGMI-20 STIT AL-Kifayah Riau, Consisting of 222 students. The researcher took 47 students as the research sample, with 23 students as an experimental class in PGMI B-20 and 24 as control class in PGMI A-20. The sample was selected by using purposive sampling techniques. This research instrument was a written test used in the pre-test and post-test. The data were analyzed using a T-test of Independent sample t-test and a paired sample t-test. The study's findings indicated substantial changes in reading comprehension abilities between the experimental and control groups. The experimental group benefited from VOA News Material via Virtual Small Group Discussion.
Designing learning trajectory based on Qur’an and Hadith: A case of fractions at Madrasah Ibtidaiyah
Authors: Rosikhoh Dewi , Abdussakir Abdussakir , Ali Fawad , Mukmin M Islahul
Published: March 2023

Islamic-based educational institutions needed to internalize Qur’an and hadith in every lesson. Fractions were one of the main subjects of mathematics taught at the elementary school level. The purpose of the study was to design mathematics learning to fractions based on Qur’an and hadith at Madrasah Ibtidaiyah. This study used a qualitative research method with a design research approach of development research type. The results of the study revealed that a learning design could be implemented with a scientific learning approach in fractions learning based on Qur’an and hadith. The verses of the Qur’an and hadith that explicitly mentioned fractional numbers were displayed at the observing stage. Each fractional number in the Qur’an and hadith was illustrated with a length model. Based on the fractional numbers mentioned in the observing stage, students were then directed to submit nutmeg questions in the questioning stage. The questions at the questioning stage were appropriate to the material, then discussed at the reasoning stage while still applying student-centered learning.
Electrical distribution system efficiency and effectiveness with simple mathematics at the Indonesian aviation Polytechnic of Curug
Authors: Arnas Yenni , Kurniawati Zulina , Ismail KGS M.
Published: March 2023

Indonesian Aviation Polytechnic of Curug (PPI Curug) uses power from PLN of 3 Mega Watts. Since the beginning implementation of the electrical system at the PPI Curug Campus, adjustments have never been made. The additions of a new distribution system did not go through careful planning, this can be shown by the data that until now there are still buildings at PPI Curug which are supplied with a voltage of 110 V per phase. Upgrading the electrical system in several buildings that are supplied with a voltage of 110 V per phase has been carried out slowly through the adjustment mechanism of the electrical installation in these buildings, and has not yet touched on the distribution system. The large number of power transformers turned out to be not proportional to the power supply borne by each transformer, and overall none of the transformers was burdened more than 40% of the nominal load. On the other hand, the number of electricity subscription bills paid by PPI Curug has increased from year to year. This study aims to determine whether the electricity distribution system used at PPI Curug is currently effective and efficient and to determine an effective and efficient electricity distribution system based on the characteristics of the area and type of load at PPI Curug. The research method used is an evaluative qualitative method which will describe the condition of the distribution system and installation at PPI Curug, then evaluate it based on existing standards. The differences that exist between the real conditions in the field and the existing standards will be used as conclusions and suggestions for improvements. The results showed that the percentage value of the efficiency of all transformers showed a value of 95% so that the efficiency of the transformer at PPI Curug was categorized as good, but the condition that there was still a large amount of unused power needed to anticipate the use of electrical power beyond the requirement.
Analysis of errors in solving mathematical literacy analysis problems using newman
Authors: Nuryati Neneng , Purwaningsih Siti Syamsiah , Habinuddin Endang
Published: March 2023

The purpose of this study was to find out student errors in solving problems about mathematical literacy. This study uses a qualitative research approach with sampling method is purposive sampling. The study subjects were three students who were taken based on KAM (Student Initial Ability), namely high, medium, and low ability categories. Each subject is one person per category from the Department of Accounting, Bandung State Polytechnic. This study analyzes student errors in solving mathematical literacy problems in the statistics course for the sub-discussion of hypothesis testing. The error analysis method used is Newman analysis. This study uses two instruments, namely a test instrument with four questions in the form of descriptions and interviews. The data will then be classified into five error categories according to Newman's analysis. The conclusions in this study indicate that there are errors in answering questions, especially for mathematical literacy questions; students are expected to be able to analyze questions in the form of story questions; Understanding the problem instructions and information contained in the problem is the first step in working on mathematical literacy problems so that the level of errors and errors in working on the questions is more resolved. Of the five errors that became the standard for Newman Error Analysis assessment, three errors were made by respondents, namely errors in understanding story questions correctly, errors in transforming story questions into mathematical sentences, and errors in writing the final answer.
The Renaissance of Astrological Poetry: Scientific Sources of Basinio da Parma’s Astronomicon libri
Authors: Chisena Anna Gabriella
Published: March 2023

The Astronomicon libri of Basinio da Parma is the first Latin astronomical poem written during the Italian humanism movement. According to the information we possess, Basinio composed the poem at the Malatestian court in 1455. It is usually believed that the work is nothing more than an “imitation” of Aratus’s Phaenomena or Hyginus’s De astronomia, and that it lacks real scientific competence in the astronomical and astrological fields. This article, however, aims to present a brief analysis of the poem by examining the results that have emerged through the preparation of its new critical edition. In particular, thanks to both the recognition of a new Basinio autograph and the Greek glosses inserted therein, this article will show how Cleomedes’s Greek astronomical treatise, Μετέωρα (Caelestia), can be considered the main source of Basinio’s Astronomicon libri.
Ut legis, ita vertis ! Autour de deux traductions françaises de Platon à la Renaissance
Authors: Le Blanc Charles
Published: March 2023

Cet article entend illustrer comment la traduction est un témoin de la façon dont les textes sont lus d’une époque à une autre, et que le traducteur traduit tout autant un texte que sa façon de le lire (Ut legis, ita vertis). Plus encore, le temps où advient la lecture d’un texte n’est pas nécessairement le temps de l’écriture de celui-ci, si bien que le traducteur introduit souvent le texte qu’il traduit à une dimension temporelle différente du texte originel et que ce dernier ne pouvait prévoir d’emblée. À cet égard, l’étude des traductions s’inscrit dans un contexte assez vaste où le chercheur doit expliquer les différents éléments qui ont mené à telle ou telle lecture du texte traduit. Ce type d’étude, la « philologie génétique de la traduction », trouve ici un exemple dans la contextualisation de la première traduction française connue du Phédon de Platon par Jean de Luxembourg.
The Heritage Impact Study Assessment (HIA) in the sustainable development of the Coast of Melaka
Authors: Muhamad Asyaari , Husaini Amir , Amirah Yasmin
Published: March 2023

Through the strategic plan of Melakaku Maju Jaya 2035 (PSMJ 2035), the State of Melaka has implemented several modern development policies aimed at triggering the economy and increasing the state’s revenue. One of the aspects applied is the question of land development in Melaka through the introduction of the Melaka-Waterfront Economic Zone (M-WEZ) project. This development project involves the development of an area of 10,117 hectares along the coast of Central Melaka. However, the results of this development planning have directly triggered a polemic among state policy planners and the National Heritage Department, since this development involves several very sensitive issues. Among the issues that are often raised is the preservation and conservation of the heritage and history of the state of Melaka. Therefore, the writing of this article will describe the role and process of Heritage Impact Assessment (HIA) as a conflict-solving tool in assessing the implications, as well as provide recommendations and mitigation measures that need to be implemented in any area to be developed, especially in the aspect of maritime HIA study, to enable both the sustainable development and maintenance of the historical heritage of the state of Melaka to move in line with development.
Highlights

HIA acts as a conflict-solving tool in the dispute of heritage versus development in the Melaka coastal area
Methodology used in the HIA study involves local oral history (interviewing informants), scientific survey, and visual survey
Artifacts found in the Melaka coastal area in this HIA study are not so significant to the state's heritage and history
Developers need to be careful during the reclamation stage as precautionary measures
The establishment of the Heritage Impact Assessment study is a significant step forward regarding the conservation and protection of the cultural World Heritage values
RNA helicase DHX15 exemplifies a unique dependency in acute leukemia
Authors: Guo Hao , Xu Jin , Xing Peiqi , Li Qilong , Wang Donghai , Tang Chao , Palhais Bruno , Roels Juliette , Liu Jiaxu , Pan Sa , Huang Jinyan , Liu Zhaoqi , Zhu Ping , Taghon Tom , Qing Guoliang , Van Vlierberghe Pieter , Liu Hudan
Published: March 2023

RNA-binding proteins (RBP) have emerged as essential regulators that control gene expression and modulate multiple cancer traits. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from transformation of T-cell progenitors that normally undergo discrete steps of differentiation in the thymus. The implications of essential RBP during T-cell neoplastic transformation remain largely unclear. Systematic evaluation of RBP identifies RNA helicase DHX15, which facilitates the disassembly of the spliceosome and release of lariat introns, as a T-ALL dependency factor. Functional analysis using multiple murine T-ALL models demonstrates the essential importance of DHX15 in tumor cell survival and leukemogenesis. Moreover, single-cell transcriptomics reveals that DHX15 depletion in T-cell progenitors hinders burst proliferation during the transition from doublenegative to double-positive cells (CD4-CD8- to CD4+CD8+). Mechanistically, abrogation of DHX15 perturbs RNA splicing and leads to diminished levels of SLC7A6 and SLC38A5 transcripts due to intron retention, thereby suppressing glutamine import and mTORC1 activity. We further propose a DHX15 signature modulator drug ciclopirox and demonstrate that it has prominent anti-T-ALL efficacy. Collectively, our data highlight the functional contribution of DHX15 to leukemogenesis through regulation of established oncogenic pathways. These findings also suggest a promising therapeutic approach, i.e., splicing perturbation by targeting spliceosome disassembly, may achieve considerable anti-tumor efficacy.
PARP1 and POLD2 as prognostic biomarkers for multiple myeloma in autologous stem cell transplant
Authors: Thomas Melissa , Li Junan , King Kevan , Persaud Avinash K , Duah Ernest , Vangundy Zachary , Hofmeister Craig C. , Lamba Jatinder K. , Tan Aik Choon , Fridley Brooke L. , Poi Ming J. , Seligson Nathan D.
Published: March 2023

Multiple Myeloma (MM) is an incurable plasma cell malignancy often treated by autologous stem cell transplant (ASCT). Clinical response to ASCT has been associated with DNA repair efficiency. Here we interrogated the role of the base excision DNA repair (BER) pathway in MM response to ASCT. Across 450 clinical samples and six disease stages, expression levels of genes in the BER pathway were found to be highly upregulated during the development of MM. In a separate cohort of 559 patients with MM treated with ASCT, expression of BER pathway members MPG and PARP3 was positively associated with overall survival (OS) while expression of PARP1, POLD1, and POLD2 was negatively associated with OS. In a validation cohort of 356 patients with MM treated with ASCT, PARP1 and POLD2 findings were replicated. In patients with MM who never received ASCT (n=319), PARP1 and POLD2 were not associated with OS, suggesting that the prognostic effect of these genes may be treatment-dependent. In preclinical models of MM, synergy was observed in anti-tumor activity when poly (ADPribose) polymerase (PARP) inhibitors (olaparib, talazoparib) were used in combination with melphalan. The negative prognosis associated with PARP1 and POLD2 expression along with the apparent melphalan-sensitizing effect of PARP inhibition may suggest this pathway as a potential biomarker in patients with MM in the setting of ASCT. Further understanding of the role of the BER pathway in MM is vital to improve therapeutic strategies related to ASCT.
Momelotinib (JAK1/JAK2/ACVR1 inhibitor): mechanism of action, clinical trial reports, and therapeutic prospects beyond myelofibrosis
Authors: Tefferi Ayalew , Pardanani Animesh , Gangat Naseema
Published: March 2023

Janus kinase (JAK) 2 inhibitors are now part of the therapeutic armamentarium for primary and secondary myelofibrosis (MF). Patients with MF endure shortened survival and poor quality of life. Allogeneic stem cell transplantation (ASCT) is currently the only treatment modality in MF with the potential to cure the disease or prolong survival. By contrast, current drug therapy in MF targets quality of life and does not modify the natural history of the disease. The discovery of JAK2 and other JAK-STAT activating mutations (i.e., CALR and MPL) in myeloproliferative neoplasms, including MF, has facilitated the development of several JAK inhibitors that are not necessarily specific to the oncogenic mutations themselves but have proven effective in countering JAK-STAT signaling, resulting in suppression of inflammatory cytokines and myeloproliferation. This non-specific activity resulted in clinically favorable effects on constitutional symptoms and splenomegaly and, consequently, approval by the Food and Drug Administration (FDA) of three small molecule JAK inhibitors: ruxolitinib, fedratinib, and pacritinib. A fourth JAK inhibitor, momelotinib, is poised for FDA approval soon and has been shown to provide additional benefit in alleviating transfusion-dependent anemia in MF. The salutary effect of momelotinib on anemia has been attributed to inhibition of activin A receptor, type 1 (ACVR1) and recent information suggests a similar effect from pacritinib. ACRV1 mediates SMAD2/3 signaling which contributes to upregulation of hepcidin production and iron-restricted erythropoiesis. Targeting ACRV1 raises therapeutic prospects in other myeloid neoplasms associated with ineffective erythropoiesis, such as myelodysplastic syndromes with ring sideroblasts or SF3B1 mutation, especially those with co-expression of a JAK2 mutation and thrombocytosis.
Gestión de calidad de los servicios de neurocirugía en un hospital público de Ecuador
Authors: Cañar Lascano Geovanny German , Espinoza Solis Eduardo
Published: March 2023

Introducción: medir el resultado es una parte fundamental de la buena práctica médica, definir la calidad de la atención y evaluar la efectividad de las intervenciones, los resultados actúan como puntos finales en los ensayos clínicos para guiar la práctica basada en la evidencia, siendo estos los protagonistas del desempeño individual de los cirujanos. A medida que la práctica médica cambia de atención centrada en la enfermedad a atención centrada en el paciente, los resultados informados por el paciente han tenido prioridad en la salud. Es posible que las medidas no aborden lo que más importa a los pacientes, aunque se reconocen cada vez más los efectos holísticos de la enfermedad en múltiples aspectos del bienestar de las personas, como la utilidad de las intervenciones enfocadas en términos de calidad de vida y síntomas de los pacientes, además de las medidas biológicas de la enfermedad. Metodología: Se realizará un estudio cualitativo, descriptivo y reflexivo que pretende identificar los factores que influyen en la calidad de vida posterior a los procedimientos quirúrgicos. Resultados: Serán medidos mediante entrevista a los pacientes tipo encuesta sobre el modelo SERVQUAL de forma presencial o telefónica a pacientes atendidos en el servicio de neurocirugía que fueron sometidos a diversos procedimientos quirúrgicos. Discusión: Existe una necesidad de realizar de forma protocolaria una PROM en pacientes neuroquirúrgicos para abordar las necesidades no satisfechas de los pacientes posterior a someterse a procedimientos neuroquirúrgicos.
Factibilidad de la soldadura TIG en ensamblado de aluminio 6063 extruido para fabricación de automóviles
Authors: Solís Santamaria Javier Milton , Semblantes Claudio Yadira Maricela , Villacís López Juan Antonio , Herrera Santamaria Diego Paul
Published: March 2023

Introducción. Uno de los materiales más utilizados en los diversos procesos industriales es el aluminio, debido a su gran versatilidad y bajo peso, gran maleabilidad y conformabilidad, resistencia a la corrosión y alta conductividad eléctrica. Su aparición ha permitido un gran auge en el desarrollo de nuevas técnicas, métodos y aplicaciones. Dentro de los métodos de unión se encuentran los procesos de soldadura, y en específico el proceso de soldadura TIG (Tungsten Inert Gas) el cual utiliza una atmósfera de gas Argón para proteger la formación del cordón de soldadura. Objetivo. El presente estudio está enfocado en analizar la factibilidad de la soldadura TIG en el ensamblado de aluminio 6063 extruido para fabricación de automóviles. Metodología. Se basa en investigaciones de tipo documental y bibliográfica. Resultados. Se basaron en los análisis de las características de la aleación 6063, la extrusión de los metales y las características de la soldadura. Conclusión. Se obtuvo fragilización del material base a causa del calentamiento al arco eléctrico, así como, disminución de la resistencia a la tracción y aumento en la dureza del aluminio ante un procedimiento de soldadura.  Para minimizar y solucionar los efectos descritos anteriormente en las características del aluminio, se debe recurrir posterior al proceso de soldadura, a un tratamiento térmico.
Effect of Anterior Nasal Packing on Middle Ear Pressure
Authors: Jonaed Fazle Elahi , Chowdhury M Alamgir , Hossen Md Iqbal , Kazi Milon , Rumi Shaikh Nurul Fattah , Osmany Husne Qumer
Published: March 2023

Background: Bilateral anterior nasal packing is often done after septal surgery for hemostatic reasons and mechanical splinting. It has been suggested that nasal packing following septal surgery is a frequent cause of short term eustachian tube dysfunction such as ear fullness and mild pain.
Objectives: To evaluate the effect of anterior nasal packing on middle ear pressure.
Methods: For this prospective, longitudinal study, ninety-two (92) patients admitted for routine septal surgeries were selected according to inclusion and exclusion criteria from the in-patient Department of ENT and Head &Neck Surgery, Dhaka Medical College and Hospital, Dhaka during 1st January 2020 to 31st July 2021. Following informed written consent, the patients were interviewed three times: preoperative, after 24 hours of ANS pack and 6 days after pack removal. During each time, middle ear pressure was measured by an impedance audiometer. Any otological symptoms produced when ANS pack was in place for 24 hours and 6 days after pack removal were also observed and recorded.
Results: Among 92 patients in this study, mean preoperative middle ear pressure was -5.5 (± 30.14) daPa. After 24 hours of anterior nasal packing, 70 ears (38%) showed abnormal middle ear pressure among 184 ears. Mean middle ear pressure after 24 hours of ANS pack was -76.5 (± 58.8) daPa. Middle ear pressure again measured after 6 days of removal of ANS pack and showed that the middle ear pressure of all the patients were within normal range. Mean middle ear pressure was -12.4(± 36.5) daPa after 6 days of pack removal. Some otological symptoms developed due to change in middle ear pressure following ANS pack like ear fullness, earache and tinnitus. All these symptoms subsided after 6 days of pack removal.
Conclusion: Anterior nasal packing decreases middle ear pressure which is reversible and returns to normal 6 days after pack removal. Some otological symptoms developed due to change in middle ear pressure which were transient and all came to normal after 6 days of pack removal.
Bangladesh J Otorhinolaryngol 2022; 28(2): 135-140