bluuebunny/crossref_metadata_2025 huggingface dataset:
Topical steroids for the management of peristomal hypertrophic granulation tissue
Authors: Kitahara Yuma , Sommerlad Matthew , Coltart George
Published: December 2024

Background Peristomal skin complications, including hypertrophic granulation tissue (HGT), are prevalent issues in stoma care. HGT presents as a shiny, red, friable lesion surrounding the stoma and is also known as hypergranulation, overgranulation, or ‘granuloma’. Standard treatment for HGT involves topical silver nitrate, but its efficacy over other treatment modalities is unclear. We present the case of a 58-year-old woman with an 18-month history of peristomal HGT.Methods Three treatments were trialled on separate affected areas in an n-of-1 trial of treatment: clobetasol propionate 0.05% ointment under occlusion, silver nitrate, and electrofulguration. Outcomes were evaluated after four weeks based on the resolution of granulation tissue and the presence of side effects, including cutaneous atrophy, bleeding, and discomfort.Results Clobetasol propionate achieved complete resolution of HGT within four weeks, with no recurrence, atrophy, or complications. In contrast, silver nitrate and electrofulguration demonstrated minimal efficacy. Remaining lesions were treated successfully with clobetasol propionate, leading to successful resolution without side-effects.Conclusions This is the first head-to-head trial of topical application of clobetasol propionate ointment against silver nitrate and electrofulguration for the treatment of peristomal HGT. Our case demonstrates superior efficacy of clobetasol propionate ointment. Larger studies are recommended to establish standardized treatment protocols for HGT, including optimal topical corticosteroid strength and duration. Given its accessibility, practicality, and efficacy demonstrated in our case, we recommend topical corticosteroids as first-line treatment for peristomal HGT.
Neoadjuvant Androgen Deprivation Therapy Before Radical Prostatectomy in High and Very High-Risk Prostate Cancer
Authors: Hsieh Chia-Chih , Cheng Wan-Yu , Tseng Wen-Hsin , Ho Chung-Han , Liu Chien-Liang , Huang Steven K. , Chiu Allen W.
Published: December 2024

Objectives: Neoadjuvant systemic therapy is a standard of care for several solid tumor malignancies. It has been evaluated prior to radical prostatectomy in recent studies but no consensus yet. This study investigates the outcomes of high-risk prostate adenocarcinoma receiving radical prostatectomy (RP) with or without neoadjuvant androgen deprivation therapy (ADT).
Methods: This study included 175 patients diagnosed with high- or very-high-risk prostate adenocarcinoma who underwent robotic-assisted RP with pelvic lymph node dissection from January 2017 to December 2022. Among them, 50 patients received neoadjuvant-ADT before the operation. The study analyzed baseline characteristics, comorbidities, and surgical outcomes, comparing approaches using chi-squared and Student’s t-tests.
Results: Of the 175 patients, a total of 50 (28.7%) patients received neoadjuvant-ADT and 124 (71.3%) didn’t. On comparing the PSA level between the two groups, we found that the initial PSA were significantly higher in neoadjuvant-ADT group (p=0.025) and also significantly dropped to lower level before operation when comparing with non-neoadjuvant-ADT group (p<0.001). Clinical stage according to MRI also showed down-staging in neoadjuvant-ADT group. Pathological stage showed no difference between 2 groups (p=0.847) but surgical margin free rate was higher in neoadjuvant-ADT group (50% vs. 70%, p=0.016). Disease-free rate (p=0.363) and PSA recurrence rate (p=0.774) showed no difference between two groups. Upon neoadjuvant ADT group, primary biopsy Gleason score and residual tumor volume can be predicators for the disease progression. No cancer-related mortality was noted.
Conclusions: This study supports neo-adjuvant ADT group had better surgical outcomes and no lower prognosis compared with non-neoadjuvant ADT group. Neo-adjuvant ADT prior to RP can be considered in high- or very-high-risk prostate adenocarcinoma patients.
Stability analysis of Mamdani-type fuzzy controllers by calculating the Lyapunov exponent
Authors: Qrich Jaouad , hadjoudja abdkaddar
Published: December 2024

Determining the stability of the controllers, either through simulations orthrough analytical techniques, is vital in their design and implementation.The analytical method of stability in the sense of Lyapunov requires findinga candidate function, as a sufficient but not necessary criterion for that pur-pose. This candidate function is elusive for fuzzy controllers. It is proposed,as a possible solution to this problem, to quantify the stability of the fuzzycontrollers using the Lyapunov exponent (EL) calculated numerically. Thetime series from which the Lyapunov exponents are calculated is obtainedfrom the output of various closed-loop Mamdani-type fuzzy controllers withthe nonlinear plant dynamics stabilized in an admissible region of operation.The experiments were carried out by implanting the numerical method on theplatform MATLAB, integrating it with data from the simulation of variousfuzzy controllers. The plant to be controlled is the inverted car-pendulumsystem modeled with the Euler-Lagrange formulation. In each experiment,the time series corresponding to the control signal was obtained and theLyapunov exponent was calculated. Although variations in magnitude areobserved, the calculated exponent is negative in all cases. This indicates thatthe Mamdani-type fuzzy controllers used are dissipative systems. As futurework, the use of EL in adaptive control is outlined.
Artificial-Intelligence-Enabled Digital Stethoscope Significantly Improves Point-of-Care Screening for Clinically Significant Valvular Heart Disease
Authors: Rancier Moshe , Israel Igor , Monickam Vimalson , Currie Caroline , Verschoore Ben , Lastowski Emileigh , Pelt Douglas W , Prince John , McDonough Rosalie V
Published: December 2024

Clinically significant valvular heart disease (VHD) affects 1 in 10 adults over 65 but often goes undiagnosed. In a real-world study of 368 patients, an AI-enabled digital stethoscope demonstrated significantly higher sensitivity than primary care providers (94.1% vs. 41.2%, p=0.002) for detecting audible VHD, albeit with slightly lower specificity. These results suggest that AI-assisted auscultation can enable earlier VHD detection in primary care, improving diagnosis, patient care, and outcomes.
The Impact of Psychostimulant Use on Office Based Buprenorphine Treatment Retention
Authors: Edgerton Ryan , Rebeiro Peter , MacMaster Sam , Bell Lisa , Patel Parul , Beach Kyra , Shah Veeraj , Cooper Robert
Published: December 2024

Background: Over a million people have died from overdose since 1999, over 600,000 of which involved opioids. Treatment options that focus on overdose prevention as opposed to recovery are desperately needed. Co-morbid opioid and stimulant use disorders have increased at a higher rate than other co-morbid combinations between 2011-2019.
Methods: We conducted an analysis of a cohort of 143 individuals with opioid use disorder that initiated treatment in an urban office based opioid treatment (OBOT) clinic. Retention was measured at 1, 3, and 6-months. Logistic regression was used to identify differences between groups.
Results: Patients testing positive for cocaine use prior to 6-month follow-up had 5.31 higher odds of not being retained in treatment (95% CI: 1.16-24.38). Patients testing positive for methamphetamine had no significant effect on retention at any of the time points.
Conclusion: We attempted to identify the effects of stimulant use on retention in MOUD treatment in a low-threshold OBOT clinic. The findings of this study provide evidence that low resource, low-threshold clinics are viable venues to treat patients with opioid use disorder with co-occurring stimulant use. These findings are critical as access to MOUD treatment is low, and new venues that are easy to access are desperately needed.
Bridging the Gap in Medical Waste Management: A Comparative Analysis of Government and Private Healthcare Facilities in Abuja, Nigeria
Authors: Aja Aja Maurice , Enaworu Oghenetanure Ryan , Orobator Enibokun Theresa , Chiawah Jones Azefor Sango , Taiwo Moyosore , Nwozor Joshua T. , Awosan Wuraola , Umar Amina Emidowojo , Abiodun Olaiya Paul
Published: December 2024

Background
Healthcare facilities (HCF) are significant producers of healthcare waste (HCW), which includes hazardous materials such as sharps, pharmaceuticals, infectious substances, and chemical agents. Inadequate management of HCW presents serious risks to human health and the environment, especially in low- and middle-income countries, including Nigeria. Despite global guidelines for HCW management, challenges such as insufficient infrastructure, training, and adherence to regulations persist, particularly in regions like the Bwari Area Council, Abuja. This study evaluates healthcare workers' knowledge, attitudes, and practices (KAP) regarding healthcare waste management, compares practices between private and public healthcare facilities, and assesses adherence to national guidelines.
Methods
A cross-sectional study was conducted among 425 healthcare workers from ten healthcare facilities (five private, five public) in the Bwari Area Council. A random sampling technique was used, and a self-administered questionnaire assessed the participants' knowledge and practices related to healthcare waste management. Data were analyzed using SPSS version 28.0.
Results
Private healthcare workers demonstrated significantly better knowledge of waste segregation (92.5% vs. 84.9%, p = 0.012) and identifying vaccine containers as medical waste (80.8% vs. 70.8%, p = 0.016) compared to government workers. In practice, a significantly higher proportion of private workers refrained from flushing liquid medical waste into toilets (71% vs. 65%, p = 0.040). In contrast, government workers exhibited more positive attitudes towards waste management, with 99.3% agreeing that medical waste should be properly handled compared to 97.0% in private facilities (p = 0.016). Both private and government workers displayed high knowledge of color coding for medical waste (94.6% vs. 93.5%, p = 0.650), but only 15.1% correctly identified the green color code for general waste.
Conclusion
Private healthcare workers demonstrated better knowledge of waste segregation, while government workers showed more positive attitudes toward waste handling. Both sectors had similar practices, with gaps in the liquid waste disposal and general waste color coding. Targeted interventions and consistent training are needed to improve waste management practices across both facility types.
Mental Illness Stigma Research Based on the Quad Model and ReAL Model: From Personal-centered Perspective
Authors: Siliang Yang
Published: December 2024

Background：Currently, there remain some ambiguities in the research on mental illness stigma. One issue is that studies on the relationship between explicit and implicit stigmas of mental illness are divided into two camps: the high-correlation theory, which suggests a unity between the two, and the low-correlation theory, which advocates for their separation. Another issue is the "relativity" of the results from Implicit Association Tests (IATs), which has led to controversy over research conclusions.
Methods：A total of 62 college students were recruited as volunteers to participate in the study, which employed a range of psychological scales, including emotional scales, social distance scales, and stereotype scales. The explicit attitudes of the participants toward mental illness were examined through latent profile analysis, while the implicit attitudes were assessed using Implicit Association Tests(IAT), analyzed based on the quad model and the ReAL model. Additionally, the study explored the relationship between explicit and implicit attitudes toward mental illness.
Results：Based on the heterogeneity in college students' explicit attitudes toward mental illness, they could be divided into two subgroups, named "Acceptance Group" (39.66%) and "Stigma Group" (60.34%), respectively. The "mental Illness patients - negative" automatic activation parameter (AC, Quad model, χ2(1)=28.807, p<0.001) and the evaluative associative processing parameter for mental Illness patients (A, ReAL model, χ2(1)=10.826, p<0.01) reached significance, both indicating that college students have a significant negative implicit attitude towards mental Illness. The evaluative associative processing parameter A for the "acceptance group" of college students was not significantly different from 0.5 (χ2(1)=1.202, p=0.273), while the A parameter for the "stigma group" of college students was significantly less than 0.5 (χ2(1)=3.888, p<0.05), indicating that the acceptance group subjects held a neutral implicit attitude towards mental Illness patients, while the stigma group subjects held a negative implicit attitude.
Conclusion: College students exhibit both explicit and implicit stigma towards mental illness. Over 60% of the participants showed a tendency for explicit stigma, with the most prominent issue being discriminatory behavior towards individuals with mental illness, followed by negative perceptions of mental illness. College students with neutral implicit beliefs tended to display accepting explicit attitudes, whereas those with implicit stigma tended to show stigmatizing explicit attitudes.
DIFFICULT INTUBATION IN FACE AND NECK BURN PATIENTS AT THE SEQUELAE STAGE
Authors:   High Care Burn Unit, Mohamed V Military Teaching Hospital, Rabat, Morocco., Amine El Alaoui Hafid , Walid Atmani ,   Anesthesiology and Intensive Care Unit, Mohamed V Military Teaching Hospital, Rabat, Morocco., Benakrout Aziz ,   Anesthesiology and Intensive Care Unit, Mohamed V Military Teaching Hospital, Rabat, Morocco., El Bouti Anas ,   Anesthesiology and Intensive Care Unit, Mohamed V Military Teaching Hospital, Rabat, Morocco., Abdelhafid Achbouk ,   High Care Burn Unit, Mohamed V Military Teaching Hospital, Rabat, Morocco., Amine Khales ,   High Care Burn Unit, Mohamed V Military Teaching Hospital, Rabat, Morocco., Bensghir Mustapha ,   Anesthesiology and Intensive Care Unit, Mohamed V Military Teaching Hospital, Rabat, Morocco., Hicham Balkhi ,   Anesthesiology and Intensive Care Unit, Mohamed V Military Teaching Hospital, Rabat, Morocco.
Published: December 2024

Tracheal intubation in face and neck burn patients at the sequelae stage can be challenging or even impossible in certain cases. Ventilation techniques using a laryngeal mask or intubation with a bronchial fiberoscope provide solutions to most difficult intubation scenarios. The authors present two cases involving female patients with face and neck burn sequelae.
SOCIAL MEDIAS IMPACT ON ONLINE CONSUMER PURCHASE BEHAVIOR
Authors:   Research Student, Department of Management Studies, Achariya Arts and Science College, Pondicherry., George Varghese Eben , S.G Sureshrajan ,   Faculty Member in Department of Management Studies, Achariya Arts and Science College, Pondicherry.
Published: December 2024

Selling through social media has increasingly become as one of the most significant variables in a Consumer purchasing decision. On top of the formal channels like online marketplace and e-commerce websites. It is confirmed that Face book is among the top three social media sites in online shopping. Electronic commerce has become popular especially in recent years. In the line with the popularity of electronic commerce, This study examined Social Medias Impact on Online Consumer Purchase Behavior and it has paid extra attention to research more on online impulsive behavior.
The relationship between social entrepreneurship orientation, business planning, and competitive advantage on cooperative performance: Moderation of the socio-economic context
Authors: Nurmayanti Poppy , Mutia Basri Yesi , Nur DP Emrinaldi , Indrawati Novita
Published: December 2024

This study delves into the determinants influencing the efficacy of social enterprises, specifically cooperatives. This study aims to examine the interaction between social entrepreneurial orientation (SEO), strategic planning, and competitive advantage in shaping cooperative performance, accounting for the moderating influence of the socio-economic context. A population of cooperatives in Indargiri Hilir and Bengkalis regencies, Riau Province, Indonesia, served as the study’s focus. A sampling strategy was employed to distribute 500 questionnaires to cooperative managers. Of these, 298 were returned and analyzed using partial least squares (PLS). The findings corroborate a positive association between SEO and financial performance with a p-value of 0.000. Likewise, SEO affects competitive advantage and company planning (p-value 0.000). The exploration indicates no mediating role for business strategy in the relationship between financial performance and SEO, with a p-value of 0.136. However, strategic planning acted as a mediator in the relationship between SEO and social performance (p-value 0.011). Moreover, the findings show that SEO has a favorable influence on social performance through competitive advantage with a p-value of 0.000. Thus, the moderating role of socio-economic context on the relationship between SEO and financial performance can be proven with a p-value of 0.000, as well as on the relationship between business planning and financial performance with a p-value of 0.016. These empirical findings can inform policymakers’ strategic development of inclusive and sustainable policies that foster growth and resilience of cooperatives.
AcknowledgmentAuthors are grateful to LPPM Riau University for providing research grants with contract number 993/UN19.5.1.3/AL.04/2024.
SAĞLIK HİZMETLERİ COĞRAFYASI AÇISINDAN BURSA ULUDAĞ ÜNİVERSİTESİ HASTANESİNİN ETKİ ALANININ BELİRLENMESİ (2017-2021)
Authors: Özdogan İsmail
Published: December 2024

Sağlık hizmetlerinin en önemli bileşenlerinden biri olan hastaneler bireylerin teşhis, tedavi sürecinin yapıldığı alanlardır. Sağlık hizmetleri sunan bu kurumların lokasyonu, hizmet kalitesi, hangi basamakta sağlık hizmeti sunduğu önemlidir. Bu çalışmanın amacı Bursa ilinin önemli sağlık kuruluşlarından biri olan Bursa Uludağ Üniversitesi Hastanesinin 2017-2021 yılları arasındaki istatistiki verileri dikkate alınarak etki alanının belirlenmesi olmuştur. Çalışma sağlık kurumlarının hizmet alanlarının belirlenmesi ve etki alanlarının ortaya konması açısından önemlidir. Araştırmada nicel araştırma yöntemi kullanılmıştır. Araştırmada elde edilen veriler tablo ve haritalara dönüştürülmüştür. Etki alanını belirlemek amacıyla ArcGIS 10.7 yazılımı kullanılmıştır. Türkiye için referans bir sağlık kuruluşu olan ve eğitim araştırma hastanesi olarak hizmet veren Bursa Uludağ Üniversitesi Hastanesi, 3. basamak sağlık hizmeti sunan bir kurumdur. Hem Bursa ilinin çevre illere göre sağlık hizmet bölgesi olması hem de bu hastanenin eğitim araştırma hastanesi statüsünde olması komşu illerden hatta Türkiye’nin diğer illerinden de sağlık hizmeti talep edenlerin tercih ettiği bir hastane olmasını sağlamıştır.
Şeker Pancarı Atığı Katkılı Kil Zeminin Serbest Basınç ve Konsolidasyon Verilerinin İrdelenmesi
Authors: Özbahçeci Gökdeniz İlkim , Bağrıaçık Baki
Published: December 2024

Yapılan bu çalışmada toz şeker üretiminde kullanılan şeker pancarının işlenme sonrası arta kalan posaları ile zeminin geoteknik özelliklerine katkısı incelenmiştir. Şeker pancarı posası bol miktarda su içeriğine sahiptir. Suyu uzaklaştırmak amacı ile şeker pancarı 1 gün süre ile etüv yardımı ile kurutulmuştur. Şeker pancarı atığı (ŞPA) öğütülerek elek analizi yapılmıştır. ŞPA katkısının optimum miktarını belirlemek amacı ile doğal kil zemine %0,25, %0,5, %0,75, %0,85 ve %1 oranlarında şeker pancarı atığı içeren serbest basınç numuneleri hazırlanmıştır. Ek olarak zemin iyileştirmeye katkısı bilinen biyopolimerlerin ŞPA ile çalışıp çalışmayacağı belirlenmek için Arabic Gum (AG) kullanılmıştır. Arabic Gum (AG) katkılı numuneler 7 farklı yüzde içeriği ile hazırlanmıştır. Hazırlanan numuneler ile optimum atık ve biyopolimer oranı bulunmuştur. Optimum oranları belirlenen ŞPA + AG karışımı olumlu sonuç vermemiştir. İdeal kür süresini belirlemek için belirlenen oranda ŞPA içeren zemine 1, 3, 5, 7 ve 10 gün kür süresi ile serbest basınç deneyine tabii tutulmuştur. Doğal kil zemin ve ŞPA katkılı optimum oranlarda hazırlanan zemin numunesi dayanım değerleri karşılaştırılmıştır. Sonuçta optimum oranlarda atık içeriği ile hazırlanan zemin, doğal kil zeminden 3,62 oranında daha fazla dayanıma sahiptir. Biyopolimer katkısı eklenen ŞPA numuneleri olumlu sonuç vermemiştir. Fakat konsolidasyon deneyi aşamasında optimum oranda biyopolimer eklenmiş ve olumlu sonuçlar elde edilmiştir. Tüm seri deneyler sonucunda şeker pancarı atığının killi zeminin dayanım ve konsolidasyon parametrelerinde iyileşme sağladığı sonucuna varılmıştır.
Habitar el tiempo. Breves consideraciones sobre el cuidado de la casa común
Authors: Yáñez Maximiliano
Published: December 2024

En la encíclica Laudato si´ (2015) se realiza un diagnóstico sobre los principales problemas ecológicos a los cuales nos enfrentamos hoy en día, haciendo un llamado a cuidar nuestra casa común. ¿Pero cómo debemos cuidarla? En el presente artículo, mostraremos la importancia de habitar el tiempo a la hora de querer enfrentarnos a la crisis ecológica. Específicamente reflexionaremos sobre cómo al hacernos conscientes de la influencia del tiempo en nuestro día a día podemos adoptar una vida más acorde con el mundo que nos rodea, y sobre todo con Dios. De este modo, si bien, la relación entre el tiempo y Dios está muy presente en la historia del pensamiento occidental, por ejemplo, en San Agustín, Santo Tomás de Aquino, Newton, Leibniz, Levinas, por mencionar sólo algunos, su relación con el medio ambiente no es tan evidente, ni tampoco una línea de argumentación común. Por este motivo, en el presente artículo intentaremos mostrar la importancia que tiene comprender la naturaleza del tiempo a la hora de querer establecer soluciones a la cuestión ecológica.
Prevalence of asymptomatic dermatophytes carrier cats in high population density households in Lavras–MG city
Authors: Lúcia Sousa Resende Isa , Aline Migotto Beatriz , Ribeiro Diego , Júlia Barbosa Brigagão Anna , Yoiti Kitamura Kawamoto Fernando , Botelho de Abreu Claudine
Published: December 2024

Dermatophytosis is a significant zoonosis in the world. This study aimed to investigate the prevalence of asymptomatic dermatophytes carrier cats in high population density households in Lavras (MG) city and to analyze the epidemiological factors associated with this condition. A total of 160 cats were evaluated through coat samples collected by brushing. The coat samples were inoculated in Dermatophyte Test Medium culture. After colony growth, they underwent microscopic analysis to identify dermatophytes. Statistical analysis was performed using the Chi-square test or Fischer's Exact test to assess the association between variables, determining relative risk. Twenty-seven cats (16.9%) were asymptomatic carriers, with the species Nannizzia gypsea (66.7%) were the most prevalent. There was a significant association between age and the occurrence of dermatophyte carrier status, with cats over six years old were 1.8 times more likely to occur. Mixed-breed, females, long hair, mature adults and outdoor cats were more prevalent, although there was no significant association with dermatophyte carrier status. Only one owner and their cat had a previous history of dermatophytosis. The prevalence of asymptomatic dermatophytes carrier cats in high population density household in Lavras-MG city was low, with no evidence of harm to animal and human health.
Anesthetic protocol in a greylag goose (Anser anser) undergoing prolapse reduction and cloacoplasty
Authors: Priscilla Borges Albuquerque Maria , Silva La Rocca de Freitas Sofia , Estela Mendes da Silva Maria , César Silva Ray , Aparecida Silva Thaís , de Barros Bandarra Márcio
Published: December 2024

The objective of this study was to describe an anesthetic protocol in a greylag goose (Anser anser), using propofol as the induction agent, for surgical prolapse reduction and cloacoplasty. The goose was considered suitable for surgery after disease diagnosis and a thorough pre-anesthetic evaluation. Pre-anesthetic medication included intramuscular administration of butorphanol, midazolam, and ketamine at doses of 0.5, 0.5, and 9 mg kg-1, respectively. Subsequently, intravenous administration of propofol at 5 mg kg-1 over one minute allowed for airway intubation but did not achieve the surgical plane of anesthesia. Two additional one-minute boluses of propofol were administered, but the goose still exhibited paddling and caruncle retraction reflexes. The effective propofol dose to reach the ideal surgical plane was 10 mg kg-1 min-1 over 5 minutes, without apnea events, with a post-induction decrease in systolic blood pressure. Using propofol as anesthetic agent was satisfactory and suitable for the procedure and safe for the animal, indicating its potential as an alternative to inhalation agents for both optimizing anesthetic induction and simple, short-duration procedures under conditions contraindicating inhalant agents.
Detection of heat stress in boer goats using infrared thermography and different methodologies
Authors: Ribeiro Miranda Jaciara , Pinheiro Lopes Neto José , Cordeiro da Silva Valquíria , Michel Batista dos Santos Ruan , Gonçalves Pereira Araújo Tiago , Araújo Furtado Dermeval
Published: December 2024

The objective of this research was to measure the surface temperature of goats by means of thermography, as well as to analyze if there is a difference between the amount of points collected to evaluate the average surface temperature. The research was carried out in a climatic chamber, evaluating the body surface temperature of goats using different methodologies at different air temperatures. The experimental design used was completely randomized with a 3x4 factorial scheme (three temperatures and four points of surface temperature collection) with six replications. The data obtained were evaluated using the Statistical Analysis System by applying the analysis of variance and Tukey test for the significant variables. However, it is concluded that there is no difference between the analysis of the average surface temperature in 3 or 8 points of the body, being proposed the analysis in 4 points, being forehead, side, neck and shin, considering that they are the places where it occurs more intense cutaneous evaporation in goats.
Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats
Authors: Fan Naling , Guo Teng , Du Liying , Liu Mingfeng , Chen Xinran
Published: December 2024

Objective:

Tacrolimus, a calcineurin inhibitor (CNI), is the first-line treatment for chronic myeloid
leukemia (CML) and advanced gastrointestinal stromal tumors (GIST). Imatinib and tacrolimus are both substrates
of the hepatic enzymes CYP3A4/5 and efflux transporter P-gp, so drug-drug interactions may occur during
their co-administration treatment. Therefore, this study aimed to evaluate the pharmacokinetic interaction
between imatinib and tacrolimus in rats.

Methods:

Rats were divided into groups I (30 mg/kg imatinib administered for 14 days), II (1.89 mg/kg tacrolimus
and 30 mg/kg imatinib administered for 14 days), III (30mg/kg imatinib and 0.63mg/kg tacrolimus administered
for 14 days), IV (1.89mg/kg tacrolimus for 14 days), and V (10mg/kg imatinib and 1.89mg/kg tacrolimus
for 14 days). Blood samples were determined for whole blood of tacrolimus, plasma of imatinib, and Ndesmethyl
imatinib concentrations using ultra-performance liquid chromatography-mass spectrometry.

Results:

After 1 day of a single dose, tacrolimus had no significant effect on the pharmacokinetics of imatinib
and N-desmethyl imatinib; imatinib significantly increased the AUC and Cmax of tacrolimus (P < 0.05). After
14 days of multiple doses, tacrolimus significantly reduced the AUC and Cmax of imatinib and N-desmethyl
imatinib (P < 0.05). Further, imatinib significantly increased AUC0-24 and AUC0-∞ of tacrolimus (P < 0.05).

Conclusion:

Imatinib increased tacrolimus blood concentrations after single and multiple administrations.
Tacrolimus did not significantly affect the pharmacokinetics of imatinib after a single dose; however, tacrolimus
might impact the absorption and metabolism of imatinib after multiple doses. The results showed that
when imatinib and tacrolimus were co-administered, attention should be paid to the presence of drug-drug interactions.
Outbreak Transmission of Coronavirus- A Case Study
Authors: Mamatha Elliriki
Published: December 2024

Introduction:

The COVID-19 pandemic, originating in Wuhan, China, swiftly spread
globally, wreaking havoc on both personal lives and economic stability.

Method:

Its highly contagious nature, transmitted through human contact, necessitated urgent government
interventions worldwide. Measures such as quarantine, social distancing, and lockdowns,
alongside medical awareness campaigns, were earnestly adopted to mitigate its impact.

Results:

While the development of a cure remains a time- consuming endeavor, the focus has shifted
towards prevention through diverse strategies, explored in this study.

Conclusion:

Presenting a stochastic model, this paper aims to analyze the percentage of affected individuals
across various factors, highlighting the efficacy of lockdown measures at different intervals.
Impact of Artificial Intelligence–Generated Content Labels On Perceived Accuracy, Message Credibility, and Sharing Intentions for Misinformation: Web-Based, Randomized, Controlled Experiment
Authors: Li Fan , Yang Ya
Published: December 2024

Background

The proliferation of generative artificial intelligence (AI), such as ChatGPT, has added complexity and richness to the virtual environment by increasing the presence of AI-generated content (AIGC). Although social media platforms such as TikTok have begun labeling AIGC to facilitate the ability for users to distinguish it from human-generated content, little research has been performed to examine the effect of these AIGC labels.

Objective

This study investigated the impact of AIGC labels on perceived accuracy, message credibility, and sharing intention for misinformation through a web-based experimental design, aiming to refine the strategic application of AIGC labels.

Methods

The study conducted a 2×2×2 mixed experimental design, using the AIGC labels (presence vs absence) as the between-subjects factor and information type (accurate vs inaccurate) and content category (for-profit vs not-for-profit) as within-subjects factors. Participants, recruited via the Credamo platform, were randomly assigned to either an experimental group (with labels) or a control group (without labels). Each participant evaluated 4 sets of content, providing feedback on perceived accuracy, message credibility, and sharing intention for misinformation. Statistical analyses were performed using SPSS version 29 and included repeated-measures ANOVA and simple effects analysis, with significance set at P<.05.

Results

As of April 2024, this study recruited a total of 957 participants, and after screening, 400 participants each were allocated to the experimental and control groups. The main effects of AIGC labels were not significant for perceived accuracy, message credibility, or sharing intention. However, the main effects of information type were significant for all 3 dependent variables (P<.001), as were the effects of content category (P<.001). There were significant differences in interaction effects among the 3 variables. For perceived accuracy, the interaction between information type and content category was significant (P=.005). For message credibility, the interaction between information type and content category was significant (P<.001). Regarding sharing intention, both the interaction between information type and content category (P<.001) and the interaction between information type and AIGC labels (P=.008) were significant.

Conclusions

This study found that AIGC labels minimally affect perceived accuracy, message credibility, or sharing intention but help distinguish AIGC from human-generated content. The labels do not negatively impact users’ perceptions of platform content, indicating their potential for fact-checking and governance. However, AIGC labeling applications should vary by information type; they can slightly enhance sharing intention and perceived accuracy for misinformation. This highlights the need for more nuanced strategies for AIGC labels, necessitating further research.
The CareVirtue Digital Journal for Family and Friend Caregivers of People Living With Alzheimer Disease and Related Dementias: Exploratory Topic Modeling and User Engagement Study
Authors: Pickett Andrew C , Valdez Danny , White Lillian A , Loganathar Priya , Linden Anna , Boutilier Justin J , Caldwell Clover , Elliott Christian , Zuraw Matthew , Werner Nicole E
Published: December 2024

Background

As Alzheimer disease (AD) and AD-related dementias (ADRD) progress, individuals increasingly require assistance from unpaid, informal caregivers to support them in activities of daily living. These caregivers may experience high levels of financial, mental, and physical strain associated with providing care. CareVirtue is a web-based tool created to connect and support multiple individuals across a care network to coordinate care activities and share important information, thereby reducing care burden.

Objective

This study aims to use a computational informatics approach to thematically analyze open text written by AD/ADRD caregivers in the CareVirtue platform. We then explore relationships between identified themes and use patterns.

Methods

We analyzed journal posts (n=1555 posts; 170,212 words) generated by 51 unique users of the CareVirtue platform. Latent themes were identified using a neural network approach to topic modeling. We calculated a sentiment score for each post using the Valence Aware Dictionary and Sentiment Reasoner. We then examined relationships between identified topics; semantic sentiment; and use-related data, including post word count and self-reported mood.

Results

We identified 5 primary topics in users’ journal posts, including descriptions of specific events, professional and medical care, routine daily activities, nighttime symptoms, and bathroom/toileting issues. This 5-topic model demonstrated adequate fit to the data, having the highest coherence score (0.41) among those tested. We observed group differences across these topics in both word count and semantic sentiment. Further, posts made in the evening were both longer and more semantically positive than other times of the day.

Conclusions

Users of the CareVirtue platform journaled about a variety of different topics, including generalized experiences and specific behavioral symptomology of AD/ADRD, suggesting a desire to record and share broadly across the care network. Posts were the most positive in the early evening when the tool was used habitually, rather than when writing about acute events or symptomology. We discuss the value of embedding informatics-based tools into digital interventions to facilitate real-time content delivery.
The CareVirtue Digital Journal for Family and Friend Caregivers of People Living With Alzheimer Disease and Related Dementias: Exploratory Topic Modeling and User Engagement Study (Preprint)
Authors: Pickett Andrew C , Valdez Danny , White Lillian A , Loganathar Priya , Linden Anna , Boutilier Justin J , Caldwell Clover , Elliott Christian , Zuraw Matthew , Werner Nicole E
Published: December 2024

BACKGROUND

As Alzheimer disease (AD) and AD-related dementias (ADRD) progress, individuals increasingly require assistance from unpaid, informal caregivers to support them in activities of daily living. These caregivers may experience high levels of financial, mental, and physical strain associated with providing care. CareVirtue is a web-based tool created to connect and support multiple individuals across a care network to coordinate care activities and share important information, thereby reducing care burden.

OBJECTIVE

This study aims to use a computational informatics approach to thematically analyze open text written by AD/ADRD caregivers in the CareVirtue platform. We then explore relationships between identified themes and use patterns.

METHODS

We analyzed journal posts (n=1555 posts; 170,212 words) generated by 51 unique users of the CareVirtue platform. Latent themes were identified using a neural network approach to topic modeling. We calculated a sentiment score for each post using the Valence Aware Dictionary and Sentiment Reasoner. We then examined relationships between identified topics; semantic sentiment; and use-related data, including post word count and self-reported mood.

RESULTS

We identified 5 primary topics in users’ journal posts, including descriptions of specific events, professional and medical care, routine daily activities, nighttime symptoms, and bathroom/toileting issues. This 5-topic model demonstrated adequate fit to the data, having the highest coherence score (0.41) among those tested. We observed group differences across these topics in both word count and semantic sentiment. Further, posts made in the evening were both longer and more semantically positive than other times of the day.

CONCLUSIONS

Users of the CareVirtue platform journaled about a variety of different topics, including generalized experiences and specific behavioral symptomology of AD/ADRD, suggesting a desire to record and share broadly across the care network. Posts were the most positive in the early evening when the tool was used habitually, rather than when writing about acute events or symptomology. We discuss the value of embedding informatics-based tools into digital interventions to facilitate real-time content delivery.
“A Multi-Method Approach to Understanding Secondary Traumatic Stress in Emergency Department Nurses: Formation Processes and Policy Brief”: A Methodology Protocol (Preprint)
Authors: Motie Mahdieh , Fallahi-khoshknab Masoud , Mohammadi Shahbolaghi Farahnaz , Khanjani Mohammad Saeed , Stueck Marcus , Khankeh Hamidreza
Published: December 2024

BACKGROUND

Secondary traumatic stress (STS) is a psychological phenomenon that refers to the negative and traumatic emotional experiences that individuals experience as a result of exposure to the pain and suffering of others, particularly in caring professions such as emergency nursing. This not only affects the mental health of nurses but can also have a significant impact on the healthcare system.

OBJECTIVE

We will conduct this study to deeply explore the phenomenon of secondary traumatic stress and compile a policy brief.

METHODS

This study will be a multi-method approach through qualitative research of grounded theory methodology, a literature review, and the Delphi method, and will culminate in the compilation of a policy brief.

RESULTS

it is protocol study

CONCLUSIONS

Secondary traumatic stress is a complex health problem affecting emergency nurses due to their frequent exposure to distressing situations. Profound investigations are essential to understand this complicated phenomenon better. The findings can help reduce its psychological and physical impacts, improve job satisfaction, and enhance patient care. Health policymakers should use these results as a guiding framework for support and interventions.
Editorial: Responsible Design, Integration, and Use of Generative AI in Mental Health (Preprint)
Authors: Asman Oren , Torous John , Tal Amir
Published: December 2024

BACKGROUND

Editorial

OBJECTIVE

Editorial

METHODS

Editorial

RESULTS

Editorial

CONCLUSIONS

Editorial

CLINICALTRIAL

Editorial
Adolescent Cyberbullying and Cyber Victimization: A Longitudinal Study Before and During COVID-19 (Preprint)
Authors: Schulz Peter Johannes , Boldi Marc-Olivier , van Ackere Ann
Published: December 2024

UNSTRUCTURED

Adolescent cyberbullying has been a persistent issue, but the onset of COVID-19 — with its shift to remote learning and increased screen time — has sparked concerns about its potential rise. Leveraging a Panel dataset, we examine the same group of adolescents both before and during the pandemic, exploring how factors such as age, exposure to violent media, parental communication quality, internet access, gender, and sibling relationships influence cyberbullying behavior at school. We also investigate how the COVID-19 pandemic may have altered these dynamics.

We conclude that the perceived quality of parental communication reduces the risk of both cyberbullying perpetration and victimization, the former effect becoming more pronounced during COVID-19. In comparison, exposure to violent media increases both cyber perpetration and victimization, but the former effect decreased during COVID-19. Our study also confirmed the well-established correlation between internet access and both cyber perpetration and victimization, a relationship unaffected by COVID-19. Independently of the COVID-19 impact, our study revealed a surprising insight: adolescents with siblings were less prone to becoming either victims or perpetrators of cyberbullying at school.
Bağımsız Denetime Tabi Hastane Hizmeti Sunan TFRS ve BOBİ FRS’yi Uygulayan Sağlık Kuruluşlarının Karşılaştırmalı Finansal Analizi (2018-2022)
Authors: Bozdemir Enver
Published: December 2024

Çalışmanın amacı, finansal tabloları bağımsız denetimden geçen özel hastanelerin finansal durumu ve performansının finansal açıdan analiz edilmesidir. Çalışmada nitel yöntem kullanılmıştır. Kamu Gözetimi Muhasebe ve Denetim Standartları Kurumu (KGK) tarafından yayımlanan 2018-2022 yıllarına ait Hastane hizmetleri sektörünün Finansal Durum Tablosu ile Kar veya Zarar Tablosu verileri analiz edilmiştir. Elde edilen verilerin analizinde hastanelerin likidite, varlık kullanımı, finansal yapı ve karlılık durumları karşılaştırılarak incelenmiştir. Çalışma hem Türkiye Finansal Raporlama Standartlarını (TFRS) hem de Büyük ve Orta Boy İşletmeler için Finansal Raporlama Standardını (BOBİ FRS) uygulayan ve bağımsız denetime tabi olan hastane işletmeleri kapsamaktadır. Bu kapsamda 2018’de 102, 2019’da 100, 2020’de 106, 2021’de 87 ve 2022’de 117 hastane işletmesinin analizi yapılmıştır. Elde edilen bulgulara göre, TFRS’ye tabi işletmelerin likidite, varlık kullanımı, finansal yapı ve karlılık analizi açısından BOBİ FRS’ye tabi işletmelere göre daha iyi oldukları görülmüştür. Buna karşın her iki Standarda tabi olan hastanelerin finansal durumlarının 2021-2022 yıllarında istenilen seviyede olmadığı tespit edilmiştir. Bu çalışma sağlık işletmelerinin pandemi ve sonrası dönemler açısından finansal analizi, sağlık hizmetleri sektörünün karlılıklarının etkilenme düzeyinin tespiti bakımından literatüre katkı sağlamaktadır.
Forest Environment Characteristics for Health Therapy in Bunder Grand Forest Park, Gunungkidul, Special Region of Yogyakarta
Authors: Pertiwi Serly Andini , Nurjani Emilya , Hadisusanto Suwarno
Published: December 2024

Healing forests maintain health through preservative practices, allowing benefits to emerge when site conditions support the practices. Therefore, this research aimed to identify the biophysical components and physical elements of the healing forests in Bunder Grand Forest Park (GFP). This research adopted observation methods and spatial analysis to characterize the healing forests' biophysical components and physical elements. The results showed that Bunder GFP had a diverse biodiversity and a distinctive landscape with the potential to provide comfort for visitors. It also met the criteria outlined in SNI 9006:2021, with medium thermal comfort levels. This research suggested vegetation enrichment to enhance the park's therapeutic potential, decrease noise, and increase thermal comfort. Additionally, the existing water features, karst rocks, and mixed forest vegetation can be used as media for sensory stimulation, further supporting health therapy.
Modeling and Statics Analysis of Outsole Structure of Men's Shoes Based on Finite Element Method
Authors: Wan Pengbo , Wu Yu , Tian Xue
Published: December 2024

In order to explore the influence of the heel structure of men's shoes on the deformation of the outsole, and simulate the stress distribution and deformation of the outsole in different human states, taking the existing leisure men's shoes outsole as the research object, the "sole-ground" coupling finite element model was established through reverse engineering, and the instantaneous stress of the sole was simulated and statically analyzed. The stress and strain areas of the model under different working conditions are consistent with those under the real test, mainly in the area where the transverse stiffener at the heel meets the inner edge. This paper applies finite element analysis to the static analysis of soles, which can provide new ideas for the design of regional structure of outsole heel of men's shoes, and improve the utilization rate of sole materials and sole performance.
Analysis of Influencing Factors of Low-carbon Purchases
Authors: Wang Shuang , Liu Jinxiao , Ji Bohan
Published: December 2024

Social norms are informal rules that govern group behavior and are a powerful motivator for the formation of low-carbon purchasing habits. Based on SOR theory, this study conducts a questionnaire survey on 499 consumers and uses social norms, future orientation, Perceived Consumer Effectiveness, low-carbon purchasing Intention, and the value of doctrine of the mean Scale to conduct an empirical analysis through the fsQCA method to configure the antecedent variables that affect low-carbon purchasing willingness. The findings indicate that: social norms, future orientation, perceived consumer effectiveness, the value of doctrine of the mean have positive impact on low-carbon purchasing willingness. Furthermore, in the absence of social norms, future orientation and the value of doctrine of the mean are sufficient conditions to influence the formation of low-carbon purchasing behavior will.
Effect of soil compaction on the initial development of corn
Authors: Fronza Bruno Estefano , Cerqueira Felipe Facundes , Santos Guilherme Rocha Dos
Published: December 2024

Corn is one of the oldest crops of great economic and social importance, used in human and animal food and in various industries. In 2022/2023, world production was 1,155.6 million tons, with a forecast of 1,235.7 million for 2023/2024. Brazil, the third largest producer in the world, with around 130 million, is also the largest exporter. Corn productivity faces challenges such as soil compaction, especially in the cerrado, which reduces root growth and nutrient absorption, negatively impacting production. The research sought management practices to mitigate these effects, varying according to the type of soil, species and level of compaction. The research was carried out with the objective of evaluating the effect of soil compaction in the initial phase of corn cultivation. This is a descriptive, explanatory research, experimental and field study, carried out in Porto Nacional – TO, through four treatments and five replications, with soil subjected to different compactions (0, 50, 100 and 150kg) by hydraulic press. For compaction, a hydraulic press was used, subjected to weights of 50 kg for Treatment A, 100 kg for Treatment B and 150 kg for Treatment C and Treatment D test 0 kg, The TD treatment presented the highest average values for plant height (AP), shoot dry matter (MSPA) and mean root dry matter (RMS), reaching 40%, 17% and 4.2%, respectively, these results indicate that the Proper management of soil compaction conditions is essential to optimize plant development.