bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-Treatment Serum Complement 3 Levels And Rituximab Response In Idiopathic Membranous Nephropathy
Authors: ONAN Engin , TORUN Dilek , ÖZELSANCAK Rüya , MİCOZKADIOĞLU Hasan
Published: October 2023

Objective: The efficacy of rituximab has been reported in patients with idiopathic membranous nephropathy (MN). We aimed to evaluate the relationship between biochemical tests at diagnosis, immunohistochemical profile, and rituximab response in patients with idiopathic MN unresponsive to other therapies in our center.

Material and Methods: In this study, nine patients with idiopathic MN who received other immunosuppressive therapies between 2017-2022 and who underwent renal biopsy in our center were evaluated. Pre-treatment phospholipase A2 antibody levels were positive in 6 patients, and antibodies could not be analyzed in 3 patients. All patients received rituximab ≥2 grams after renin-angiotensin-aldosterone system (RAAS) blocker, cyclophosphamide, steroid, and calcineurin inhibitors.

Results: Of the nine patients included in the study, 7 (78.2%) were male, and the mean age was 39.713.2 years. Four patients had complete remission (CR) with rituximab treatment, and five had partial remission (PR). Sclerotic glomeruli count, IgG, A, M, C1q, C3, C4d, fibrinogen, kappa and lambda staining, tubular atrophy, and interstitial fibrosis findings on renal biopsy were similar. However, the serum complement 3 (C3) level was significantly lower within normal limits (1.22  0.26 vs 1.560  0.56 p=0.016). The mean arterial pressure was significantly higher (96.22.5 mmHg vs 84.754.27 mmHg, p=0.018) in patients with partial remission compared to those with complete remission.

Conclusion: A low baseline serum C3 level within normal limits before treatment in patients with idiopathic membranous nephropathy may help predicting unresponsiveness to other immunosuppressive therapies and partial response to rituximab treatment.
Blending Modalities, Pedagogies, and Technologies: Redesigning an Information Systems Course to Encourage Engagement
Authors:   School of Information Management Victoria University Wellington, New Zealand, Doyle Cathal , Chiu Yi-Te ,   School of Information Management Victoria University Wellington, New Zealand
Published: October 2023

Having realized that the traditional approach to teaching our IS course on Business and Systems Analysis was not engaging students enough, we decided we needed to redesign our learning environment. The goal was to develop a course that encourages student participation, allows them to practice the different techniques we introduce them to, and empowers students to take control of their learning. To achieve this, we blended modalities (online and in-person), pedagogies (constructivist and collaborative approaches), and technologies (student-centered technologies). This resulted in a redesign that included replacing the lecture with learning resources of a digestible size and an activity-based discussion, the workshop focusing on a project for authentic problems, sense-making via doing and reflection, hybrid participation in a steady and sustainable pace, and learning communities to enable more interaction. In this paper, we share our experience and lessons that we have learned through a journey toward a student-centered approach to learning.
BOŞANMANIN DENEYİMLENMESİ ÜZERİNE KARMA BİR DESEN ÇALIŞMASI: ERKEKLERİN GÖZÜNDEN BOŞANMA
Authors: Yılkan İhsan , Yaman Ömer Miraç
Published: October 2023

Sürekli artış gösteren ve toplumsal bir sorun haline gelen boşanma, bireyler açısından da çeşitli problemlere neden olmaktadır. Bu çalışmada, boşanmış erkeklerin, erkeklik bağlamında yaşadığı boşanma deneyimlerinin incelenmesi amaçlanmıştır. Çalışma, karma yöntem kullanılarak yakınsayan paralel desende tasarlanmıştır. Çalışmanın nicel kısmı için sosyo-demografik sorularla beraber; FISHER Boşanma/Ayrılığa Uyum ölçeği-Kısa Formu ve Yaşam Doyumu Ölçeği kullanılmıştır. Nitel kısımda ise araştırmacı tarafından hazırlanan nicel veri toplama araçları ile paralellik gösteren, yarı yapılandırılmış görüşme formu kullanılmıştır. Araştırmanın nicel aşaması için 400, nitel aşaması için 18 boşanmış erkekten veri toplanmıştır. Elde edilen nicel ve nitel veriler ayrı ayrı analiz edilmiştir. Araştırmanın nicel bulgularında katılımcıların demografik bilgileri ile ölçeklerin ilişkili veriler sunulmuştur. Nitel kısımda ise boşanmış erkeklerin çocuklarına dair deneyimleri, yasal süreçlere ilişkin deneyimleri, baş etme mekanizmaları ve boşanma uyumlarına ilişkin veriler sunulmuştur. Son kısımda ise nicel ve nitel veriler birleştirilerek literatürle birlikte tartışılmıştır. Araştırmanın sonucuna göre boşanma olgusu muhatap olduğu tüm kesimleri etkilemektedir. Eril düzen içinde erkek olmanın da zor olduğu, bu anlamda erkeklerin boşanma durumunda olumsuz deneyimler yaşadığı, boşanma sürecinde ve sonrasında pek çok sorun yaşadıkları anlaşılmıştır. Boşanmış erkeklerin başlıca; ekonomik problemler, psikolojik problemler, kalacak yer sorunu, çocuklarını görememe, nafaka problemi, ebeveyne yabancılaşma sorunu, yalnızlık, dışlanmışlık vb. sorunlar yaşadıkları görülmüştür.
ERRATUM: THE EFFECT OF WAGE ON PRIVATE SECURITY OFFICERS JOB SATISFACTION AND INTENTION TO QUIT: AN EMPIRICAL STUDY IN TURKEY
Authors: Demirci Uğur , Ergen Banu
Published: October 2023

Düzeltme: Dergimizde yayınlanmış olan “The Effect of Wage on Private Security Officers Job Satisfaction and Intention to Quit: An Empirical Study in Turkey. Elektronik Sosyal Bilimler Dergisi, 19(75), 1314-1334. https://doi.org/10.17755/esosder.616419” referanslı makale, “Demirci, U. (2019). İş Doyumu ile İşten Ayrılma Niyeti İlişkisine İstihdam Şekillerinin Etkisi. Uluslararası Sosyal Araştırmalar Dergisi, 12(62), 1246-1258. DOI:10.17719/jisr.2019.3134” referanslı makale verisi kullanılarak yazılmış ancak sehven dipnot verilmesi unutulmuştur. Yapılan bu hatadan dolayı yazarlar, okuyuculardan özür diler.Bu makalenin ilk hali 01-07-2020 tarihinde yayınlandı. https://dergipark.org.tr/tr/pub/esosder/issue/53427/616419
DÜZELTME: ÖĞRETMEN ADAYLARININ SOSYAL MEDYA ORTAMLARINI KULLANMA DURUMLARINA GÖRE ÇOK KÜLTÜRLÜ EĞİTİME İLİŞKİN GÖRÜŞLERİ: TÜRKİYE ÖRNEĞİ
Authors: Hark Söylemez Nesrin , Oral Behçet
Published: October 2023

Dergimizin 2018 yılı 17.Cilt 68. Sayısında yayımlanan “Öğretmen Adaylarının Sosyal Medya Ortamlarını Kullanma Durumlarına Göre Çok Kültürlü Eğitime İlişkin Görüşleri: Türkiye Örneği” başlıklı makalede “Bu araştırma ikinci yazarın danışmanlığında, birinci yazarın “Öğretmen adaylarının sosyal medya kullanma durumlarına göre çokkültürlü eğitime ilişkin görüşleri" başlıklı doktora tezinin bir bölümüne dayalı olarak hazırlanmıştır." ifadesi yazarlar tarafından makalede dipnot olarak belirtilmiş olmasına rağmen makale yayınlanırken dergimiz tarafından bu dipnot sehven eksik verilmiştir. Makale, ikinci yazarın danışmanlığında, birinci yazarın “Öğretmen adaylarının sosyal medya kullanma durumlarına göre çokkültürlü eğitime ilişkin görüşleri" başlıklı doktora tezinin bir bölümüne dayalı olarak hazırlanmıştır.Bu makalenin ilk hali 24-10-2018 tarihinde yayınlandı. https://dergipark.org.tr/tr/pub/esosder/issue/39008/426803
Entrepreneurial Behaviour of the Agriculture Students-A review
Authors: Ku. Behera Rajeeb , Raj RK , Kumar Patra Santanu , Rout Sandeep , Chandra Sayani , Trikha Akash , Behera Chinmayee , Adhikari Bhubanananda
Published: October 2023

The present study aimed to investigate the factors that influence the entrepreneurial behavior of college students. The study identified various personal and situational factors that may affect entrepreneurial behavior. The results showed that personality traits, such as openness, extraversion, and conscientiousness, had a significant positive impact on entrepreneurial behavior. Specific motivational traits, such as entrepreneurial self-efficacy, internal locus of control, and risk-taking propensity, were also significant predictors of entrepreneurial behavior. Situational factors, such as entrepreneurship education, were found to have a significant positive impact on entrepreneurial behavior, with entrepreneurial self-efficacy playing a key mediating role in this relationship. Attitudes towards entrepreneurship were found to be a significant driver of entrepreneurial intention, with perceived desirability and feasibility, as well as perceived individual and collective efficacy, also significant predictors of entrepreneurial intention. Sustainable entrepreneurial intention was found to be influenced by attitude towards the behavior variable, with subjective norms playing an indirect role in mediating this effect. Overall, the study suggests that personal traits, such as personality and motivational factors, as well as situational factors, such as education and attitudes towards entrepreneurship, are significant predictors of entrepreneurial behavior. These findings have important implications for educators and policymakers who seek to promote entrepreneurial behavior among college students. Future research should continue to explore the complex relationships between personal and situational factors and entrepreneurial behavior to further enhance our understanding of this important phenomenon.
Knowledge and Attitude of Primary School Teachers for Periodontal Disease
Authors: Rai Jeeth , Pandrakula Sri Swathi , Bhadouria Preeti , Shrivastava Janhavi , Srinivasan Kaushik , Payak Abhishek Singh , Mehta Dhaval Niranjan
Published: October 2023

Background: This research study aimed to explore the knowledge and attitudes of primary school teachers regarding periodontal disease. Periodontal disease is a common oral health condition that can affect people of all ages, including children. Teachers play a vital role in promoting oral health among their students, and understanding their knowledge and attitudes towards periodontal disease is essential for designing effective oral health education programs. Materials and Methods: For this study, a survey was conducted among primary school teachers from various schools. The survey included questions related to their knowledge about periodontal disease, its causes, symptoms, and preventive measures. Additionally, it assessed their attitudes towards oral health promotion in the classroom. A total of 300 primary school teachers participated in the survey, providing valuable insights into their perspectives on periodontal disease. Results: Knowledge Level: The study found that 60% of primary school teachers had a basic understanding of periodontal disease. However, only 25% could correctly identify its major causes, and 45% were aware of its common symptoms. Attitudes towards Oral Health: Interestingly, 80% of teachers expressed a positive attitude towards incorporating oral health education into their teaching curriculum. They believed that educating students about oral hygiene was important. Use of Educational Resources: Approximately 70% of teachers reported using oral health educational resources such as pamphlets and videos in their classrooms. Barriers: The study also identified some barriers to effective oral health education, including a lack of time, resources, and training. Conclusion: This study highlights the varying levels of knowledge among primary school teachers regarding periodontal disease. While a majority expressed positive attitudes towards oral health education, there is a need for targeted training and resources to improve their knowledge and confidence in teaching students about periodontal disease. Efforts to overcome existing barriers should also be considered to enhance oral health promotion in primary schools.
Histological Evaluation of A unilateral Critical-Sized Mandibular Defect Reconstruction using human dental pulp stem cells by Light Microscope and Real-Time Quantitative PCR
Authors: Ali Khalaf, Afaf, , Shamaa, Ali  , Sabry, Dina  , Saher S, Mohammed
Published: October 2023

Objective: To evaluate the osteogenic differentiation potential of human dental pulp stem cells (DPSCs) isolated from the dental pulp of third molar teeth in vitro cultures, and to evaluate the bone regenerative capacity of human dental pulp stem cells (DPSCs) when transplanted into a unilateral critical-sized bone defect in the mandibular bone in vivo after receiving a hydroxyapatite matrix and polylactic-polyglycolic acid (HA/PLGA) scaffold. Material and methods: A total of 18 mandibular defects were made, and three groups (each n = 6) were created. The first group: the transplanted DPSCs implanted in the critical-sized bone defect after receiving (HA/PLGA) scaffold. The second group received only (HA/PLGA) scaffold. The third group, which served as the control, had a critical-sized defect left empty. After characterization, Von Kossa [VK] and Alizarin red staining were employed to identify differentiated osteoblasts at the 14th and 21st days, and histological analyses, as well as polymerase chain reactions (PCR), were also used. Results: It showed that DPSCs had high proliferation potential and typical fibroblastic shape. Additionally, osteogenic differentiation of DPSCs was validated by morphological alterations, histological examination, and the expression of lineage-specific genes confirmed osteogenic differentiation of DPSCs. Conclusion: High proliferation potential and the capacity to differentiate into osteoblasts are two characteristics of DPSCs taken from impacted third molars.
Green Perspective of General Container Service vs. Dedicated Container Service from Asia to Northern Adriatic
Authors:   University of Ljubljana, Faculty of Maritime Studies and Transport Portorož, Slovenia, Golnar Marko , Beškovnik Bojan
Published: October 2023

Intermodal transport is often touted as an environmentally sustainable mode of transport, especially when considering its share of the total supply chain. This article addresses the topical and sensitive issue of supply chain assessment in terms of the carbon footprint and energy efficiency of external transportation from the point of production to the customer. The long transportation distances overseas and the variety of operational sea container services result in significant variations in delivery times from Asian markets. In addition, disruptive events such as the Covid-19 pandemic and the Ukraine conflict have led to longer transportation times and lower reliability of various maritime services. The study examines the variety of existing direct container services from Asia to the Northern Adriatic. In addition to the two direct container services already established, another dedicated container service has been established primarily to serve a large retail chain in the European market. The “newly established” container service is characterised by its limited port coverage and the use of relatively small container ships with a maximum capacity of 5.500 TEU. The comparisons between the services highlight the differences in transport time and greenhouse gas (GHG) emissions, as well as the energy efficiency of container transport. The study empirically confirms the widespread assumption that larger and modern container ships offer environmental benefits, provided that cargo space is used efficiently and ship operators adopt slow steaming. However, the study also highlights the significant differences in GHG emissions between different services and emphasises the need for more comprehensive information and awareness among cargo owners to design sustainable supply chains.
Application of Multicriteria Analysis in the Selection of the LNG Terminal Location
Authors:   University North, Department of Sustainable Mobility and Logistic Management, Primorje and Gorski Kotar County, Krpan Ljudevit , Cvitković Ivan , Poletan Jugović Tanja , Kolanović Ines
Published: October 2023

Positioning of large energy facilities is, as a rule, accompanied by a strong rejection of local and regional communities, without which it is not possible to determine the location and construction conditions for the facility in spatial plans. However, a synergy of three components may enable a successful project realization. Firstly, the application of verified and objective scientific methods for the selection of the most appropriate LNG terminal location. Secondly, the consideration of the best world practices in project documentation preparation for such terminal construction. And lastly, the continuous involvement of the local community into the entire process. The paper presents an approach aimed at solving the problem of choice by applying the methodology of choosing the “best compromise location” based on system characteristics, available data, set criteria, and limitations. The key “dimension” of such a problem is “space”, i.e. the spatial aspects of location selection. The paper provides an overview of the activities, procedures, and methods used to define the optimal location of the receiving LNG terminal in the Republic of Croatia as part of the analysis and research carried out by EKONERG and in the function of creating the Spatial Plan of Primorje-Gorski Kotar County. Accordingly, the main objective of this paper was to highlight the specifics of LNG terminal site selection as well as the possibility of objectively defining the optimal location using the multi-criteria decision-making method that simultaneously takes into account all influential factors and criteria in defining it. The paper uses the methodology of multi-attribute decision process and multicriteria analysis of the selection of the optimal location of the LNG terminal on the territory of Primorje-Gorski Kotar County. It systematically and scientifically analyses, consistently formulates, and proposes elimination and comparative criteria necessary to determine the optimal location of the LNG terminal for the purpose of drafting regional level spatial planning documents. The presented methodology was carried out using the process of multicriteria ranking of variants. The method of weighted sum values was used. Weighting factors are determined partly in an exact way (where possible) and partly based on the application of Delphi group decision-making methods. The methodology was tested on a concrete example of variant analysis for the location of LNG terminals in the Republic of Croatia. By implementing the presented methodology, the location of the northern part of the island of Krk was determined as optimal for the location of the LNG terminal. The aforementioned was implemented in the Spatial Plan of Primorje-Gorski Kotar County, and the first phase of the receiving LNG terminal was built and put into full operation.
The Analysis of the Deficiencies Resulting from Paris MoU PSC Inspections
Authors:   University of Dubrovnik, Maritime Department, Croatia, Biočić Tonći , Frančić Vlado , Hasanspahić Nermin , Maglić Lovro
Published: October 2023

Substandard ships pose a significant threat to human life and the environment. Therefore, detecting deficiencies and removing such vessels from service is necessary, which is one of the port state control (PSC) inspection tasks. In addition, the role of PSC inspection is to improve safety at sea and in ports. To be up to the task, the States jointly created several memoranda to fight against substandard ships. The most frequent deficiencies detected on ships during Paris Memorandum of Understanding (MoU) PSC inspections are analyzed in this paper. The analysis was made according to factors such as type of vessel, flag and the category to which deficiency belongs. Results revealed that most frequent deficiencies detected on ships, regardless of type or flag, come from International Safety Management (ISM) and fire protection. Furthermore, it is found that among the ten most frequent deficiencies, three are from the navigation safety category. Therefore, corrective actions to improve safety at sea are needed and presented.
Aprendizaje basado en proyecto: montaje de un panel domótico
Authors: Manzano José María
Published: October 2023

Este artículo presenta el diseño y la construcción de un panel dedicado a simular una instalación residencial real de baja tensión, así como su automatización mediante dispositivos para hogares inteligentes. Se presentan diferentes aspectos útiles para la enseñanza de asignaturas de automatización, junto con posibles extensiones futuras que se pueden incluir en el sistema. El proyecto llevado a cabo en el laboratorio de nuestra universidad consistió en el diseño, la compra, la integración y la programación de todos los elementos. Estos pasos fueron realizados por cinco estudiantes de ingeniería de cuarto año. Se proporcionan algunas consideraciones sobre su aprendizaje y las habilidades adquiridas, y se recopilan sus opiniones. Además, se consideran prácticas de laboratorio para los próximos años en este artículo, junto con posibles seminarios sobre automatización del hogar para usuarios no expertos y diferentes líneas de investigación que pueden aprovechar el uso del panel.
Búsqueda de equilibrios de Nash en juegos poblacionales bajo información parcial y su aplicación en juegos de congestión
Authors: Martinez-Piazuelo Juan , Ocampo-Martinez Carlos , Quijano Nicanor
Published: October 2023

En este artículo, consideramos el marco de dinámicas evolutivas y juegos poblacionales. Para una clase de dinámicas evolutivas y una familia de juegos poblacionales contractivos, desarrollamos un método novedoso para la búsqueda distribuida de equilibrios de Nash bajo información parcial respecto a las decisiones de los dem´as agentes. La principal contribución es que establecemos condiciones suficientes para garantizar la estabilidad asintótica del conjunto de equilibrios de Nash del juego poblacional subyacente. Además, ilustramos nuestros resultados teóricos en una aplicación numérica de un juego de congestión de gran escala.
Análisis de la frecuencia de muestreo en sistemas multi-robot
Authors: Mañas-Álvarez Francisco José , Guinaldo María , Dormido Raquel , Dormido Sebastián
Published: October 2023

Los Sistemas Ciber-Físicos, SCFs, tienen cada vez un papel más presente en la actualidad dada la sinergia que debe existir entre el mundo físico y digital en esta sociedad “conectada”. Una parte importante de estos sistemas la ocupan los Sistemas Multi-Robot, SMRs, que pueden aportar soluciones más eficientes a gran parte de los retos de la automatización actual frente a la solución homónima proporcionada por un único robot. En el presente trabajo se examina el diseño del protocolo de comunicación entre agentes de un SMR para un problema de formación por consenso de robots aéreos. Se determina la frecuencia mínima operativa a la que debe ejecutarse la comunicación periódica entre agentes conectados, 10 Hz. Finalmente se analiza el umbral de disparo que debe tener un protocolo de comunicación basado en eventos para obtener una gestión más eficiente del canal de comunicación sin empeorar el desempeño del sistema de referencia periódico, 2 cm.
Simulation of the dependence of the radiation pattern of a digital active phased array antenna on the main destabilizing factors
Authors: Pantenkov D. G.
Published: October 2023

As for today digital active phased array antennas (DAPAA), based on the principle of functioning using digital diagram formation, are actively used as part of spacecraft and unmanned aerial vehicles in solving radio communication and radar problems. At the same time, for the purposes of radar, DAPAA allows you to perceive all the information contained in the structure of spatiotemporal electromagnetic fields in the opening of the array and transform it into data on the presence and parameters of objects, providing deep compensation for broadband interference signals, which, combined with the expansion of the dynamic range when accumulated during spatiotemporal processing, provides high noise immunity of radar stations. To solve communication problems, DAPAA allows you to form several beams simultaneously, which allows you to simultaneously serve several areas at once with the possibility of dynamically changing the bandwidth in the channels due to variations in partial power.
Experimental and numerical simulation of a dual-band omnidirectional printed antenna
Authors: Dudarev S. V. , Klygach D. S.
Published: October 2023

Currently, there are many radio engineering and telecommunication systems, the exchange of information in which is carried out using radio signals. For each system, it is necessary to develop new antennas operating in a certain frequency range. Therefore, an urgent problem is development of radiating devices capable of operating simultaneously in two or more wide frequency ranges. This will allow the antenna to be used for multiple applications. The aim of the article is to develop and implement a small-sized printed antenna with a circular pattern in the azimuthal plane and horizontal polarization of the vector E, emitting and receiving a radio signal in the bands corresponding to the GSM-1800, LTE-1800, UMTS-2100 and n79 5G standards. An original design of a multilayer printed antenna with a circular radiation pattern in the azimuthal plane and horizontal polarization has been developed. The antenna consists of two printed circuit boards located one above the other. The bottom board contains a ring array of F-shaped radiators, which is excited using a high-frequency connector. The top board contains an array of passive dipoles that are excited by an electromagnetic field created by a ring array of F-shaped dipoles. According to the calculation results, the antenna emits and receives a radio signal in two frequency ranges: 1,65–2,38 GHz and 4,21–5 GHz (in terms of VSWR = 2). An antenna model has been made, its electrodynamic characteristics have been measured, and the experiment and simulation results have been compared. The developed antenna can be used as an independent radiator or an element of an omnidirectional antenna array of cellular communication standards GSM-1800, LTE-1800, UMTS-2100 and n79 5G.
Suicidal Ideation in Victims Bullying: The Role of Non-disclosure in the Family and School Contexts
Authors: Estévez Estefanía , Cañas Elizabeth , Estévez-García Francisco
Published: October 2023

The main objective of this study was to analyze the influence of adolescents’ family and school contexts in the suicidal ideation of victims of peer bullying, considering the influence of the victim’s non-disclosure of the victimization versus the victimized adolescent’s communicating the situation. The results show that parental styles of rejection and indifference are positively related to victims’ suicidal ideation and non-disclosure of bullying. Conversely, a positive school climate shows a negative relationship with victims’ suicidal ideation and the disclosure of the bullying situation. The findings also indicate that non-disclosure mediates the relationship between the mother’s parental style and suicidal ideation, whereas the school climate moderates the relationship between negative parenting styles and non-disclosure in adolescent bullying victim
Self-Organized Maker Education: Action Research at A Cross-Disciplinary University
Authors: Xing Qingqing , Cai Yihan , Zhu Nan , Yu Jing , Liu Yingbo
Published: October 2023

Fostering soft skills in students has long been the subject of intense research in the wake of the digital revolution. Various research efforts, such as Students as Partners, have also explored the possibilities of involving students as stakeholders in the co-construction of learning environments. Makerspace suitable for individual or group learning enables students to develop their knowledge, skills, and identities as designers, researchers, and/or engineers. However, little self-organized academic makerspace learning takes place at the university level in China, and few attempts have been made to conduct action research on soft skill acquisition based on maker education. This paper reports how a Chinese cross-disciplinary university cultivates the soft skills of graduate students through a series of teaching and learning activities extended from the academic makerspace. The administrative and instructional design of the master's program is analyzed at the macro (university), meso (program), and micro (curriculum) levels. The results from observation and in-depth interviews show that a “Self-organized Maker Education” culture is being built at this cross-disciplinary university, leading to resilience in academic identity formation in the learning process.
Suicidal ideation, suicide attempts and sexual harassment among transgender people in Puducherry, South India: a cross sectional analytical study
Authors: Selvaraj Manimozhi , Sarkar Sonali , Rajkumar Ravi Philip
Published: October 2023

Background: Transgender people are stigmatized, victimized and often driven towards attempting suicide due to institutionalized discrimination. We aimed, to determine the proportion and factors associated with suicidal ideation in last one year and suicide attempts in their lifetime and the proportion of transgender people who have faced sexual harassment in Puducherry.
Methods: It was a cross sectional analytical study. All consenting adult transgender residing in Puducherry and registered with SCOHD (NGO) were included in the study. Pre-tested semi structured questionnaire was used as study tools (C-SSRS and TGISS). Suicidal ideation, suicide attempts and sexual harassment were expressed in proportion and multivariate analysis was done to find the independent association of variables with the outcomes using adjusted prevalence ratios.
Results: Of the 119 transgender people who participated in this study, 50% were unemployed and 28.6% were involved in sex work. Overall prevalence of suicidal ideation, suicide attempts and sexual harassment was found to be 31.1% (95%CI 23.3%-39.8%), 46.2% (95%CI 37.4%-55.2%) and 84.87% (95%CI 77.5%-90.4%) respectively. In multivariate analyses, suicidal ideation was significantly associated with higher income; suicide attempts were associated with being employed.
Conclusions: Lack of support from the family and friends and the stigmatizing behaviour of the society were the causes of their fear of living in the society. Extreme forms of stigma ultimately leads to their suicidal behaviour.
Self-disclosure in the coexperiencing psychotherapy
Authors: Klueva Nadezhda V. , Didenko Dmitry N.
Published: October 2023

The article deals with the phenomenon of self-disclosure of a counseling psychologist to a client in the process of psychological counseling. The results of an expert interview with experienced counseling psychologists practicing the “coexperiencing psychotherapy” approach are presented, which reveal that among representatives of the approach mentioned there are different views on the place of self-disclosure in the coexperiencing psychotherapy, however, the phenomenon is somehow present in the work of coexperiencing psychologists and affects relationships within the consultation.
CRÍTICA A LA ASIGNACIÓN DE LA CATEGORÍA DE AMENAZA DE GASTROTHECA RUIZI (AMPHIBIA: ANURA: HYLIDAE)
Authors: Mueses-Cisneros Jonh Jairo
Published: October 2023

Gastrotheca ruizi ha sido considerada por Estupiñán (2004) como una especie En Peligro (EN) de acuerdo con las categorías de amenaza de la UICN por presentar un areal pequeño, fragmentado o fluctuante: B1 ab (iii); sin embargo a partir de colecciones y observaciones de campo actuales realizadas en el Valle de Sibundoy, departamento del Putumayo - Colombia (localidad típica de la especie), se obtuvo información suficiente para rechazar su asignación anterior y reasignarla dentro de la categoría de Casi Amenazado (NT). Se plantea además como una medida fundamental para la protección de esta especie endémica, incluir los hábitats donde vive dentro del Sistema de Áreas Protegidas de Colombia
UTILIDAD DEL MÉTODO EXTENDIDO DE HILDEBRAND EN EL ESTUDIO DE LA SOLUBILIDAD DEL ACETAMINOFÉN EN MEZCLAS AGUA-PROPILENOGLICOL
Authors: Martínez Fleming
Published: October 2023

En este trabajo, el Método Extendido de Solubilidad de Hildebrand (MESH), desarrollado por Martin et al., se ha aplicado al estudio de la solubilidad del acetaminofén en mezclas binarias agua-propilenoglicol a 25.00°C. Para este fin se han utilizado unos desarrollos experimentales y de cálculo, sencillos y útiles para la estimación del volumen molar del soluto y de la fracción volumétrica del solvente en la solución saturada. Se ha encontrado una adecuada capacidad predictiva del MESH al utilizar un modelo polinómico regular de cuarto orden, relacionando el parámetro de interacción W con el parámetro de solubilidad de las mezclas solventes.
Homicidios de niños, niñas y adolescentes en Colombia durante 2010-2020
Authors: Peña-Maldonado Carlos Julián , Pinzón-Flórez Carlos Eduardo
Published: October 2023

Introducción: los derechos de los niños, niñas y adolescentes prevalecen sobre los derechos de los demás. Sin embargo, países de ingreso medio como Colombia tienen una alta tasa de homicidios para este grupo poblacional, esto deja en evidencia que la sociedad no es capaz de proteger efectivamente su derecho fundamental a la vida. Objetivo: describir la tendencia de los homicidios de los niños, niñas y adolescentes en Colombia para el periodo 2010-2020. Materiales y métodos: se utilizaron los microdatos anonimizados de las defunciones no fetales de las estadísticas vitales del DANE y calcularon las tasas de homicidios para los menores de 19 años. Resultados: durante el periodo analizado, los homicidios de los niñas, niñas y adolescentes en Colombia se redujeron, al pasar de 2485 en el año 2010 a 1360 en el 2020. Discusión: los resultados de este trabajo muestran que los homicidios tienen diferencias significativas por grupo de edad, sexo y departamento, las cuales tienen determinantes que las explican, pero que es necesario abordar a profundidad en posteriores investigaciones. Conclusiones: es indispensable seguir con esta tendencia decreciente para lograr garantizar el derecho a la vida de este grupo poblacional.
Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis
Authors: Zhao ZiRan , Zhang HongYan , Zhang Fan , Ji Ying , Peng Yue , Wang Fei , Zhao Liang
Published: October 2023

Circular RNA (circRNA) sirtuin-1 (SIRT1) is differentially expressed in non-small cell lung cancer (NSCLC), but its specific mechanism is still uncertain. The study was to figure out the latent molecular mechanism of circSIRT1 in NSCLC. The results clarified that circSIRT1 and SMAD family member 7 (SMAD7) were downregulated, but microRNA (miR)-510-5p was upregulated in NSCLC. CircSIRT1 expression was linked with tumor–node–metastasis staging and tumor size in NSCLC patients. Elevating circSIRT1 or suppressing miR-510-5p refrained NSCLC cell activities and glycolysis and inactivated the wnt/β-catenin pathway, while knockdown of circSIRT1 promoted the malignant behavior of NSCLC cells. Besides, inhibition of malignant behavior in NSCLC cells by elevating circSIRT1 was reversed by knockdown of SMDA7. circSIRT1 bound to miR-510-5p to target SMAD7. In short, circSIRT1 represses NSCLC cell malignant development via miR-510-5p to target SMAD7, making it a latent target for NSCLC treatment.
The relationship between EMG high frequency and low frequency band amplitude changes correlates with tissue inorganic phosphate levels
Authors: Habich Małgorzata , Pawlinski Bartosz , Lorenc Kamil , Sady Maria , Siewruk Katarzyna , Zielenkiewicz Piotr , Gajewski Zdzislaw , Poznanski Jaroslaw , Paczek Leszek , Szczesny Pawel
Published: October 2023

Assessing inorganic phosphate levels seems crucial in deciphering the biochemical state of organisms or tissues. The concentration of inorganic phosphate in blood is an order of magnitude smaller than in tissues and, on top of that, it is dynamically used to fill temporary gaps in tissues. This is the reason blood inorganic phosphate level is considered a poor proxy for tissue levels. Therefore, tissue biopsy seems to be the dominant method when assessing inorganic phosphate levels for instance in muscles. In this study, we attempted to derive a non-invasive biomarker for phosphate tissue levels. We analyzed surface electromyography signals taken during 31P spectroscopy of leg muscles in five adult pigs. We induced hypophosphatemia via 20 minutes-long hyperventilation. It turned out that the proportion of the amplitude of the low frequency band and the high frequency band is significantly (p=0.002) correlated with the relative phosphate levels. The electromyographic signal did not correlate significantly with pCO2 levels in the blood, suggesting that the changes in the signal are a result of inorganic phosphate levels, not hyperventilation. The results might lead to the development of a real-time phosphate fluctuations measurement procedure.
Доказательство бессмысленности дальнейшего изучения проблемы депрессивных расстройств в капиталистическом мире
Authors: Колосов Г.А.
Published: October 2023

В статье приводятся доказательства в пользу того, что дальнейшее изучение депрессивных расстройств бессмысленно. Автор пришел к данному выводу на основании аргументов преобладания в проблеме депрессии социальных механизмов. Капиталистические взаимоотношения способствуют обесцениванию личности (так как личность становится инструментом заработка для капиталиста), отчуждению человека от результатов своего труда, необходимости сверхурочной работы (что есть стресс), не говоря про сам дискомфорт ощущения себя без заработка. Биологические и психологические причины депрессии могут быть первичны, но их влияние в данной среде только ухудшает социальные риски. Учитывая, что человечество пребывает преимущественно в капиталистической среде, которая продепрессивна, дальнейшее изучение проблемы депрессивных расстройств будет аргументом к отказу от капитализму. В конце приведен возможный вариант терапии депрессии «антикапиталистически» с примером эффективности данного подхода.
The Language and its Metamorphoses in Postmodernity
Authors:   Saratov State University, Kutyryova I.V.
Published: October 2023

The Postmodern Era has been widely researched in Russia and abroad. Nevertheless, it is still debatable for both Russian and Western scholars. The problem of language and its metamorphoses has become one of the key issues in this respect. We focus on studying characteristics of the postmodern period, not taking into account its value system. Thus, based on the characteristics of postmodernity we might form an idea of the language itself in the above-mentioned period, since every concept is inevitably manifested in the language.
Formation of Ecological Consciousness: Search of the Valuable Bases
Authors:   Saratov State Technical University, Losev V.S.
Published: October 2023

Ecological consciousness – the complete and rather new phenomenon of public consciousness which are as reflexion of intensity and a sharpness of an ecological situation, and certain expression, some kind of the indicator of serious changes of spiritual and material culture. The basic causal and internal characteristic of the given kind of consciousness is crisis situations developed in the modern world. It is the major condition of development of consciousness of the person in an ecological direction.
The Conceptual Bases of the Communication Conflict
Authors:   Saratov State University, Steklova N.A.
Published: October 2023

In article we present the specifics of the communication conflict and virtual person in the modern global space. In this context, concluded that it is necessary social-philosophical understanding of this phenomenon, especially since the problem of communication is connected with the disclosure of the identity of the person, their valuable installations.
Social Mythology in Russia: on a Way from an Archetype to Social Technology
Authors:   Saratov State Academy of Law, Stupin M.M.
Published: October 2023

In article considers the modern Russian social mythology, allocats the basic archetypical elements and the most widespread mythological plots, a role of social rituals during their realization. The analysis of technological methods of myth-constructing shows weak and strong sights of the approach in social management. The author pays separate attention on a problem of opposition of public consciousness to manipulations for archetypical structure of social myths.
The Social-Psychological Features of Children from One-Parent Families
Authors:   Novosibirsk State Technical University, Ivanchenko V.A.
Published: October 2023

This article is devoted to the analysis of theoretic and practical concepts about children, nurtured in one-parent families. It contains the results of investigation of motivation’s components, a socialpsychological adaptation, a preference to time perspective, a selfmanagement, communicative and organizational abilities. It shows some differences between children from one-parent family and complete family.
Psychological Features of the Students Studying at Pedagogical Specialties with the Dominance of Negative Emotions in an Examination Situation
Authors:   Bryansk State University, Tischenko Y.V.
Published: October 2023

Interconnections of different psychological characteristics of a personality with features of emotional sphere becoming apparent in an examination situation were revealed. It was shown that students with different side of emotions have specific unfavorable personality psychological features. The analysis of results of the research leads to the necessity to use more widely methods of teaching students, future pedagogues, which allow giving help in successful adaptation, resist stressful situation not only the examination one but also in farther everyday professional activity of teacher.
The Culture of Military Safety: Returning to the Past (Social and Philosophical Aspects)
Authors:   Balashov Institute (branch) of the Saratov State University, Vershilov S.A.
Published: October 2023

This article highlights that problem revealing inconsistent property of practice of culture of military safety of the states attracts attention of scientists for a long time. In fact explanation of the numerous facts of disappearance of some people and civilizations, the reason of national tragedies and accidents, waging wars and other cataclysms had to be done.
Fiscal Management Practices Framework of State Universities and Colleges in Region XII
Authors: Mamburao JR. Ruben S. , Manubag Edgar B.
Published: October 2023

This study examined the correlation between financial literacy, decision-making practices, internal control systems, and their impact on fiscal management practices in State Universities and Colleges (SUCs) within Region XII using a quantitative descriptive correlational approach. Using Pearson Correlation, the results demonstrated that these three factors are highly prevalent in SUCs and significantly influence their fiscal management practices. Interestingly, the study found that educational attainment does not mediate this relationship, as indicated by the Hayes Macro Process Model.
Moreover, the stepwise multiple regression analysis revealed that only internal control systems and financial literacy substantially affected fiscal management practices, highlighting their critical role in shaping these practices. Based on these findings, the study recommends that SUCs prioritize financial education and decision-making training and reinforce internal control systems to enhance fiscal management.
By implementing these measures, SUCs can maintain efficient and effective fiscal management practices, thereby supporting their overall institutional success and financial sustainability within the region. The significance of financial literacy, decision-making procedures, and internal control systems in shaping the fiscal management practices of educational institutions is highlighted in this study.
Osimertinib as a Potential Targeted Therapy for Non-Small Cell Lung Carcinoma (NSCLC) Patients with EGFR Exon 20 T790M
Authors: Zam Nur Zam , Iskandar Harun , Tabri Nur Ahmad , Santoso Arif , Lihawa Nurjannah , Putrawan Harry Akza , Sandra Ferry
Published: October 2023

BACKGROUND: Emergence of drug resistance due to epidermal growth factor receptor (EGFR) Exon 20 T790M poses a challenge in the effective management of non-small cell lung carcinoma (NSCLC). Significant breakthrough in the management of NSCLC with a specific genetic alteration causes substantial condition improvement in patients whose cancer progressed after first-generation tyrosine kinase inhibitor treatment and who developed tumors with EGFR Exon 20 T790M mutation. The present study analyzed a cohort of NSCLC patients and investigated the incidence of the EGFR Exon 20 T790M status with Osimertinib therapy, along with its impact on survival rates.METHODS: This was a retrospective cohort study on 22 NSCLC subjects who were genetically examined for EGFR status from plasmic cell free total nucleic acid. Subjects with EGFR Exon 20 T790M mutation were treated with/without Osimertinib. Demographic and clinical data were descriptively summarized, and the differences of each variable and correlation between survival rate and EGFR Exon 20 T790M were analyzed.RESULTS: Subjects with (n=13) and without (n=9) EGFR Exon 20 T790M had survival rates of 10.77±2.45 and 4.78±1.48, respectively (p=0.000). Based on 1-year survival status of subjects with EGFR Exon 20 T790M, there were 3 Osimertinib-treated survivors and 2 Osimertinib-treated non-survivors. Eight subjects with EGFR Exon 20 T790M and without Osimertinib treatment did not survive (p=0.001).CONCLUSION: Since the treatment of Osimertinib demonstrated a noteworthy survival rate among NSCLC subjects with EGFR Exon 20 T790M, thus Osimertinib could be suggested as a potential targeted therapy for NSCLC subjects with EGFR Exon 20 T790M.KEYWORDS: non-small cell lung carcinoma, EGFR, Exon 20, T790M, osimertinib
The Synergistic Cytotoxic Effect of Pentagamavunon-1 (PGV-1) and Curcumin Correlates with the Cell Cycle Arrest to Induce Mitotic Catastrophe in 4T1 and T47D Breast Cancer Cells
Authors: Rahmawati Desty Restia , Nurrochmad Arief , Jenie Riris Istighfari , Meiyanto Edy
Published: October 2023

BACKGROUND: The anti-cancer properties of pentagamavunon-1 (PGV-1) and curcumin have been documented. This study aimed to evaluate the cytotoxic effect of this combination on breast cancer cell growth using 4T1 and T47D cells, representing triple-negative breast cancer (TNBC) and non-TNBC, respectively.METHODS: Cytotoxic assay was evaluated using MTT reagent for single and combination treatment of PGV-1 and curcumin in 4T1 and T47D cells. Cell cycle analysis was examined through flowcytometry with propidium iodide dye. May Grünwald-Giemsa staining was also performed to analyze the mitotic catastropheRESULTS: PGV-1 and curcumin alone had significant cytotoxic effects against two breast cancer cell lines, with IC50 values of 4 μM and 40 μM for 4T1 and 2 μM and 20 μM for T47D, respectively. Both compounds showed high selectivity for the 4T1 and T47D cells (selectivity index >3). In addition, when PGV-1 and curcumin were combined, a synergistic effect was observed in both cell types with a combination index of <0.7. This combination results in cell cycle arrest in the G2/M phase, increased cell accumulation in the sub-G1 phase, and a synergistic increase in mitotic catastrophe.CONCLUSION: Combined intervention of PGV-1 and curcumin on TNBC and non-TNBC breast cancer cells substantially augments cell cycle arrest in the G2/M and sub-G1 phases, coupled with the occurrence of mitotic catastrophe. In summary, the results suggest that PGV-1 coupled with curcumin holds promise as an effective approach to addressing breast cancer and warrants further investigation.KEYWORDS: 4T1 cells, T47D cells, breast cancer, curcumin, mitotic catastrophe, PGV-1