bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and characterization of pH‐ and temperature‐responsive semi–interpenetrating polymer network hydrogels based on linear sodium alginate and crosslinked poly(N‐isopropylacrylamide)
Authors: Zhang Gao Qi , Zha Liu Sheng , Zhou Mei Hua , Ma Jing Hong , Liang Bo Run
Published: June 2005

In this study, pH‐ and temperature‐responsive hydrogels based on linear sodium alginate (SA) and crosslinked poly(N‐isopropylacrylamide) (PNIPAAm) were prepared by semi‐interpenetrating network (semi‐IPN) technique. The dually responsive hydrogels were characterized by FTIR, DSC, and SEM, and their temperature‐ and pH‐responsive behaviors were investigated by measuring equilibrium swelling ratios and pulsatile swelling experiments. The results showed that these hydrogels underwent volume phase transition at around 33°C irrespective of the pH value of the medium, but their pH sensitivity was evident only below their volume phase transition temperature. Under basic conditions, the swelling ratios of SA/PNIPAAm semi‐IPN hydrogels were greater than that of pure PNIPAAm hydrogel and increased with increasing SA content incorporated into the hydrogels, but the case was inverse under acidic conditions. The pulsatile swelling experiments indicated that the higher the SA content in SA/PNIPAAm semi‐IPN hydrogels, the faster the response rate to both pH and temperature change. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 1931–1940, 2005
Flame retardance of insolubilized silica inside of wood material
Authors: Šimkovic Ivan , Martvon̆ová Helena , Maníková Desana , Grexa Ondrej
Published: June 2005

Beech wood boards were studied with a cone calorimeter. As the specific density of these materials is greater, the total amounts of CO and CO2 produced were bigger than values measured on spruce specimens. Also, the shape of the heat release rate (HRR) curve was different as its second peak was bigger than the one observed on spruce wood. It was shown that impregnation of wood with water solutions of H3BO3 resulted in decreased HRR values with increasing acid concentrations. Mass loss and CO and CO2 production rates also decrease in the same way. Impregnation with water‐soluble NaOH‐silica resulted in improved data, when compared to untreated specimens, but were not better than those obtained with H3BO3. Simple mixing of both fire retardants gave no improvement, nor was the two‐step impregnation with drying effective after the first step. When the second step‐treatment with acid was followed without drying after impregnation with NaOH‐silica in the first step, then improvement was evident. This is explained by precipitation of the silica content inside the material when the NaOH was neutralized with H3BO3, which could penetrate inside when the material was not dried before the second step. The improvement resulted in lower smoke production and longer times to ignition. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 1948–1952, 2005
Crystallization and melting behavior of trans‐1,2‐syndiotactic polypentadiene
Authors: Bertini Fabio , Canetti Maurizio , Ricci Giovanni
Published: June 2005

(E)‐1,3‐pentadiene was polymerized at −30°C by using the catalyst system CoCl2(PiPrPh2)2–MAO. A trans‐1,2‐syndiotactic structure was attributed to the semicrystalline polymer obtained on the basis of the characterization carried out by FTIR, NMR, and WAXD techniques. The thermal behavior of the polypentadiene was investigated by thermogravimetry and differential scanning calorimetry. Isothermal melt crystallization kinetics were analyzed according to the Avrami equation. Nonisothermal crystallization kinetics were elaborated by using Ziabicki and Avrami methods modified by Jeziorny. The equilibrium melting temperature was calculated. The thermal behavior of trans‐1,2‐syndiotactic polypentadiene was compared with that of 1,2‐syndiotactic polybutadiene. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 1970–1976, 2005
Scholarly work and the shaping of digital access
Authors: Palmer Carole L.
Published: June 2005

In the cycle of scholarly communication, scholars play the role of both consumer and contributor of intellectual works within the stores of recorded knowledge. In the digital environment scholars are seeking and using information in new ways and generating new types of scholarly products, many of which are specialized resources for access to research information. These practices have important implications for the collection and organization of digital access resources. Drawing on a series of qualitative studies investigating the information work of scientists and humanities scholars, specific information seeking activities influenced by the Internet and two general modes of information access evident in research practice are identified in this article. These conceptual modes of access are examined in relation to the digital access resources currently being developed by researchers in the humanities and neuroscience. Scholars' modes of access and their “working” and “implicit” assemblages of information represent what researchers actually do when gathering and working with research materials and therefore provide a useful framework for the collection and organization of access resources in research libraries.
Expansion of human embryonic stem cells in defined serum‐free medium devoid of animal‐derived products
Authors: Li Yan , Powell Sandra , Brunette Elisa , Lebkowski Jane , Mandalam Ramkumar
Published: June 2005

Human embryonic stem cells (hESCs) can serve as an unlimited cell source for cellular transplantation and tissue engineering due to their prolonged proliferation capacity and their unique ability to differentiate into derivatives of all three‐germ layers. In order to reliably and safely produce hESCs, use of reagents that are defined, qualified, and preferably derived from a non‐animal source is desirable. Traditionally, mouse embryonic fibroblasts (MEFs) have been used as feeder cells to culture undifferentiated hESCs. We recently reported a scalable feeder‐free culture system using medium conditioned by MEFs. The base and conditioned medium (CM) still contain unknown bovine and murine‐derived components, respectively. In this study, we report the development of a hESC culture system that utilizes a commercially available serum‐free medium (SFM) containing human sourced and recombinant proteins supplemented with recombinant growth factor(s) and does not require conditioning with feeder cells. In this system, which employs human laminin coated surface and high concentration of hbFGF, the hESCs maintained undifferentiated hESC morphology and had a twofold increase in expansion compared to hESCs grown in MEF‐CM. The hESCs also expressed surface markers SSEA‐4 and Tra‐1‐60 and maintained expression of hTERT, Oct4, and Cripto genes similar to cells cultured in MEF‐CM. In addition, hESCs maintained in this culture system were able to differentiate in vitro and in vivo into cells of all three‐germ layers. The cells maintained a normal karyotype after prolonged culture in SFM. In summary, this study demonstrates that the hESCs cultured in defined non‐conditioned serum‐free medium (NC‐SFM) supplemented with growth factor(s) retain the characteristics and replicative potential of hESCs. The use of defined culture system with NC‐SFM on human laminin simplifies scale‐up and allows for reproducible generation of hESCs under defined and controlled conditions that would serve as a starting material for production of hESC derived cells for therapeutic use. © 2005 Wiley Periodicals, Inc.
Is death row obsolete? A decade of mainstreaming death‐sentenced inmates in Missouri
Authors: Cunningham Mark D. , Reidy Thomas J. , Sorensen Jon R.
Published: June 2005

Death‐sentenced inmates in Missouri have been integrated or “mainstreamed” into the general population of the Potosi Correctional Center since 1991. By comparing the rate of violent misconduct among these mainstreamed death‐sentenced inmates with that of the life‐without‐parole and parole eligible inmates under fully integrated conditions of confinement, this study provides the first empirical (statistical) evaluation of this innovative alternative to segregated death row confinement. The mainstreamed death‐sentenced inmates committed no inmate or staff homicides, or attempted homicides. Comparison of their rates of institutional violence revealed frequencies that were similar to those of life‐without‐parole inmates, and well below those of fellow inmates who were sentenced to parole eligible terms. These findings cast serious doubt on the security‐driven assumptions that have typified the segregation of death‐sentenced inmates and have dictated highly restrictive confinement policies for this group. A conclusion that death‐sentenced inmates can be safely integrated into a general prison population has significant implications for allocation of scarce fiscal resources and correctional staff, as well as for inmate mental health, particularly given the extended tenure that death‐sentenced inmates typically serve between sentencing and relief/execution. Copyright © 2005 John Wiley & Sons, Ltd.
Debtor education, financial literacy, and pending bankruptcy legislation
Authors: Wiener Richard L. , Baron‐Donovan Corinne , Gross Karen , Block‐Lieb Susan
Published: June 2005

This paper reports on an evaluation of a financial education‐training program for residents of New York who had filed for bankruptcy. Over 400 individuals divided into three groups (trained debtors, untrained debtors, and non‐debtors) completed identical questionnaires approximately three months apart. Trained debtors took the pretest before training and the post‐test after training. Results revealed that trained debtors' financial knowledge increased after training compared with untrained and non‐debtors. Trained debtors showed more negative attitudes towards unnecessary spending compared with the other two groups and reported less intention to buy than non‐debtors reported. Self‐reported behaviors showed significant changes in the desired direction for trained debtors' use of credit cards (i.e. number owned, purchases, and balance amount), paying bills, budgeting, and borrowing from predatory lenders. Implications for pending legislation are discussed. Copyright © 2005 John Wiley & Sons, Ltd.
Mechanism of Hierarchical Porosity Development in MFI Zeolites by Desilication: The Role of Aluminium as a Pore‐Directing Agent
Authors: Groen Johan C. , Peffer Louk A. A. , Moulijn Jacob A. , Pérez‐Ramírez Javier
Published: June 2005

The role of the concentration and the nature of aluminium in the creation of hierarchical porosity in both commercial and synthesized MFI zeolites have been investigated through controlled mesoporosity development by desilication in alkaline medium. Framework aluminium controls the process of framework silicon extraction and makes desilication selective towards intracrystalline mesopore formation. An optimal molar Si/Al ratio in the range 25–50 has been identified; this leads to an optimal mesoporosity centred around 10 nm and mesopore surface areas of up to 235 m2 g−1 while preserving the intrinsic crystalline and acidic properties. At lower framework Si/Al ratios the relatively high Al content inhibits Si extraction and hardly any mesopores are created, while in highly siliceous ZSM‐5 unselective extraction of framework Si induces formation of large pores. The existence of framework Al sites in different T positions that are more or less susceptible to the alkaline treatment, and the occurrence of re‐alumination, are tentative explanations for the remarkable behaviour of Al in the desilication process. The presence of substantial extra framework Al, obtained by steam treatment, inhibits Si extraction and related mesopore formation; this is attributed to re‐alumination of the extraframework Al species during the alkaline treatment. Removal of extraframework Al species by mild oxalic acid treatment restores susceptibility to desilication, which is accompanied by formation of larger mesopores due to the enhanced Si/Al ratio in the acid‐treated zeolite.
Structural and Electronic Properties of Bulk Gibbsite and Gibbsite Surfaces
Authors: Frenzel Johannes , Oliveira Augusto F. , Duarte Helio A. , Heine Thomas , Seifert Gotthard
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Layered Ordering of Vacancies of Lead Iron Phosphate Pb3Fe2(PO4)4.
Authors: Malakho Artem P. , Morozov Vladimir A. , Pokholok Konstantin V. , Lazoryak Bogdan I. , Van Tendeloo Gustaaf
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Hydrogen Bonds in Potassium Amide‐Ammonia(1/2), KNH2×2NH3.
Authors: Kraus Florian , Korber Nikolaus
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Mg1‐xRhB — A New Boridometallide with 2D Polyanion.
Authors: Alekseeva A. M. , Abakumov A. M. , Leithe‐Jasper A. , Schnelle W. , Prots Yu. , Hadermann J. , Van Tendeloo G. , Antipov E. V. , Grin Yu.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Structural and Electronic Factors Controlling the Refractive Indices of the Chalcogenides ZnQ and CdQ (Q: O, S, Se, Te)
Authors: Rocquefelte Xavier , Whangbo Myung‐Hwan , Jobic Stephane
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Electrical Conduction Properties of Sr‐Doped LaPO4 and CePO4 under Oxidizing and Reducing Conditions.
Authors: Kitamura Naoto , Amezawa Koji , Tomii Yoichi , Hanada Teiichi , Yamamoto Naoichi , Omata Takahisa , Otsuka‐Yao‐Matsuo Shinya
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Thermodynamic Assessment of the Li—Sn (Lithium—Tin) System
Authors: Yin Fucheng , Su Xuping , Li Zhi , Wang Jianhua
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Thermodynamic Assessment of the Mn—Y—O System.
Authors: Chen Ming , Hallstedt Bengt , Gauckler Ludwig J.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Li2TeS3 and Li2TeSe3: Preparation, Crystal Structure and Impedance Spectroscopic Characterization.
Authors: Preitschaft Christian , Zabel Manfred , Pfitzner Arno
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
NH4Cd(H2O)2 (BP2O8)×0.72H2O: A New Borophosphate with Abnormal Structure Changes Caused by Hydrogen Interactions.
Authors: Ge Ming‐Hui , Liu Wei , Chen Hao‐Hong , Li Man‐Rong , Yang Xin‐Xin , Zhao Jing‐Tai
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Sr2AlH7 by Ball Milling Followed by Hydrogenation.
Authors: Zhang Q. A. , Akiba E.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Disordered Pyrochlores, Ln2Ti2O7 (Ln: Y, Gd and Dy), by Mechanical Milling of Constituent Oxides.
Authors: Fuentes Antonio F. , Boulahya Khalid , Maczka Miroslaw , Hanuza Jerzy , Amador Ulises
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
RZnSn (R: Rare Earth): A Novel Series of Intermetallic Compounds with the YPtAs Structure Type.
Authors: Manfrinetti P. , Pani M.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Novel Chiral Semicrown Ether‐Like Bis(oxazoline) Ligands and Application in Enantioselective Cyclopropanation of Styrene.
Authors: Wang Zhan‐Yue , Du Da‐Ming , Xu Jia‐Xi
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
α‐Hydroxy Carboxylic Acids (I) and (II) as Ligands for Enantioselective Addition Reactions of Organoaluminum Reagents to Aromatic and Aliphatic Aldehydes.
Authors: Bauer Tomasz , Gajewiak Joanna
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Addition of Amines to the Triple Bond in α,α,α‐Trichloromethylpropargyl Mesylate: Synthesis of α,α‐Dichloromethylenaminones and Preparation of 2‐Phenyl‐4‐dichloromethylquinolines.
Authors: Si Yu‐Gui , Guo Song‐Po , Wang Wan‐Jun , Jiang Biao
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Tributylphosphine as a Superior Catalyst for the α‐C‐Addition of 1,3‐Dicarbonyl Compounds to Electron‐Deficient Alkynes.
Authors: Hanedanian Mikael , Loreau Olivier , Sawicki Marcin , Taran Frederic
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
New Application of Bromotrimethylsilane: Elaboration of Aldehydes/Ketones into Homologous α,β‐Unsaturated Esters via β‐Hydroxy Esters.
Authors: Suri Suresh C. , Marcischak Jacob C.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Dramatic Effect of Boron‐Based Lewis Acids in Cross‐Metathesis Reactions.
Authors: Vedrenne Emeline , Dupont Herve , Qualef Sabrina , Elkaim Laurent , Grimaud Laurence
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
A Chemoselective Deprotection of Trimethylsilyl Acetylenes Catalyzed by Silver Salts.
Authors: Orsini Alban , Viterisi Aurelien , Bodlenner Anne , Weibel Jean‐Marc , Pale Patrick
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
A Remarkable Iodine‐Catalyzed Protection of Carbonyl Compounds.
Authors: Banik Bimal K. , Chapa Marin , Marquez Jocabed , Cardona Magda
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
A Simple Procedure for the Synthesis of γ‐Hydroxy‐α,β‐(E)‐alkenoic Esters: Formal Synthesis of (+)‐Macrosphelides A and B.
Authors: Rao K. Srinivasa , Mukkanti K. , Reddy D. Srinivasa , Pal Manojit , Iqbal Javed
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Ligand Effects in Gold‐ and Platinum‐Catalyzed Cyclization of Enynes: Chiral Gold Complexes for Enantioselective Alkoxycyclization.
Authors: Munoz M. Paz , Adrio Javier , Carretero Juan Carlos , Echavarren Antonio M.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
1,4‐Cyclohexadienes as Mechanistic Probes for the Jacobsen Epoxidation: Evidence for Radical Pathways.
Authors: Engelhardt Ulrike , Linker Torsten
Published: June 2005

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Stereoselective Synthesis of Multisubstituted Alkenes via Conformationally Labile Alkenyllithium Species.
Authors: Yamago Shigeru , Fujita Kazuyoshi , Miyoshi Masaki , Kotani Masashi , Yoshida Jun‐ichi
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Direct Access to CF3‐Propargyl Amines and Conversion to Difluoromethyl Imines.
Authors: Magueur Guillaume , Crousse Benoit , Bonnet‐Delpon Daniele
Published: June 2005

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An Exception to the Normal Mitsunobu Reaction with Phenols: The Formation of Hydrazones from Salicylaldehydes.
Authors: Girard Mario , Murphy Philippe , Tsou Nancy N.
Published: June 2005

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tert‐Butyldiphenylsilylethyl (“TBDPSE”): A Practical Protecting Group for Phenols.
Authors: Gerstenberger Brian S. , Konopelski Joseph P.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Development of 4,4′‐Substituted‐XylBINAP Ligands for Highly Enantioselective Hydrogenation of Ketones.
Authors: Ngo Helen L. , Lin Wenbin
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Indium‐Mediated Barbier‐Type Allylation of Aldehydes as a Convenient Method for the Highly Enantioselective Synthesis of Homoallylic Alcohols.
Authors: Hirayama Lacie C. , Gamsey Soya , Knueppel Daniel , Steiner Derek , DeLaTorre Kelly , Singaram Bakthan
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Functionalization of α,β‐Unsaturated Esters and Ketones: A Facile and Highly Stereoselective One‐Pot Approach to N‐Protected α,β‐Dehydroamino Acid Derivatives.
Authors: Chen Dianjun , Guo Li , Liu Junying , Kirtane Sameer , Cannon John F. , Li Guigen
Published: June 2005

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ZnCl2‐Mediated Synthesis of Carboxylic Anhydrides Using 2‐Acyl‐4,5‐dichloropyridazin‐3(2H)‐ones.
Authors: Park Yong‐Dae , Kim Jeum‐Jong , Kim Ho‐Kyun , Cho Su‐Dong , Kang Young‐Jin , Park Ki Hun , Lee Sang‐Gyeong , Yoon Yong‐Jin
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
New Catalytic System for S—S and Se—Se Bond Addition to Alkynes Based on Phosphite Ligands.
Authors: Ananikov Valentine P. , Kabeshov Michael A. , Beletskaya Irina P. , Khrustalev Vicktor N. , Antipin Mikhail Yu.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Nickel‐Catalyzed Cross‐Coupling of Neopentyl Arenesulfonates with Methyl and Primary Alkylmagnesium Bromides.
Authors: Cho Chul‐Hee , Sun Myungchul , Seo Yong‐Seok , Kim Chul‐Bae , Park Kwangyong
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Suzuki—Miyaura Cross‐Coupling of Benzylic Carbonates with Arylboronic Acids.
Authors: Kuwano Ryoichi , Yokogi Masashi
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
A General Synthetic Route to Indenofluorene Derivatives as New Organic Semiconductors.
Authors: Hadizad Tayebeh , Zhang Jidong , Wang Zhi Yuan , Gorjanc Timothy C. , Py Christophe
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Microwave‐Assisted Suzuki Reactions for the Preparation of the Antifungal 3‐Aryl‐5‐methyl‐2,5‐dihydrofuran‐2‐ones.
Authors: Mathews Christopher J. , Taylor John , Tyte Melloney J. , Worthington Paul A.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Benzannulation of Heterocyclic Ring Systems Through Coupling of Fischer Carbene Complexes and Heterocycle‐Bridged Enynes.
Authors: Zhang Yanshi , Candelaria Daniel , Herndon James W.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of a New Class of Keto‐Linked Bis Heterocycles.
Authors: Padmavathi V. , Reddy B. Jagan Mohan , Reddy B. Chandra Obula , Padmaja A.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Regio‐ and Stereoselective Synthesis of Isoindolin‐1‐ones via Electrophilic Cyclization.
Authors: Yao Tuanli , Larock Richard C.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of Novel Indeno[1,2‐b]indol‐10‐one Derivatives by the Oxidation with DDQ.
Authors: Wang Jun‐Bo , Ji Qing‐Gang , Xu Jing , Wu Xi‐Han , Xie Yu‐Yuan
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of 2,3,5,6‐Tetrahydro‐3H‐imidazo[2,1‐b][1,3,5]benzotriazepines and Their Oxidative Ring Contraction into 1‐(4,5‐Dihydro‐1H‐imidazol‐2‐yl)‐1H‐benzimidazoles.
Authors: Saczewski Franciszek , Kobierska Ewa , Tyacke Robin J. , Hudson Alan L. , Nutt David J. , Gdaniec Maria
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Antimicrobial Activity of Some (Nitro)furfurylidene‐Containing Hexahydroindazoles.
Authors: Golikov A. G. , Raykova S. V. , Bugaev A. A. , Kriven'ko A. P. , Shub G. M.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Novel Cyclized Pifithrin‐α p53 Inactivators: Synthesis and Biological Studies.
Authors: Pietrancosta Nicolas , Maina Flavio , Dono Rosanna , Moumen Anice , Garino Cedrik , Laras Younes , Burlet Stephane , Quelever Gilles , Kraus Jean‐Louis
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Novel Synthesis of 4‐Halo‐3‐hydroxy‐2‐pyrone: One‐Pot Rearrangement—Cyclization Reaction by Magnesium Halide.
Authors: Komiyama Takuzo , Takaguchi Yutaka , Gubaidullin Aider T. , Mamedov Vakhid A. , Litvinov Igor A. , Tsuboi Sadao
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
A Case of Pictet—Spengler Revisited: Application to the Synthesis of Dihydroisocoumarins.
Authors: Choukchou‐Braham N. , Mostefa‐Kara B. , Cheikh N. , Didi M. A. , Villemin D.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
3‐(2,5‐Dihydro‐1H‐pyrrol‐2‐ylmethoxy)pyridines: Synthesis and Analgesic Activity.
Authors: Baraznenok Ivan L. , Jonsson Emma , Claesson Alf
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Regioselective Synthesis of Oxepin‐ and Oxocin‐Annulated 2‐Quinolones.
Authors: Chattopadhyay Shital K. , Dey Rajat , Biswas Suman
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Electrophilic Aromatic Addition Reaction: Electrophilic Attack at an Aromatic H Substituent Position.
Authors: Choi Han Young , Srisook Ekaruth , Jang Kun Sam , Chi Dae Yoon
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Further Studies on Ethenyl and Ethynyl‐4‐phenylamino‐3‐quinolinecarbonitriles: Identification of a Subnanomolar Src Kinase Inhibitor.
Authors: Barrios Sosa Ana Carolina , Boschelli Diane H. , Wu Biqi , Wang Yan , Golas Jennifer M.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Substituted Quinolines by Electrophilic Cyclization of N‐(2‐Alkynyl)anilines.
Authors: Zhang Xiaoxia , Campo Marino A. , Yao Tuanli , Larock Richard C.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Aminocyanopyridine Inhibitors of Mitogen Activated Protein Kinase‐Activated Protein Kinase 2 (MK‐2).
Authors: Anderson David R. , Hegde Shridhar , Reinhard Emily , Gomez Leslie , Vernier William F. , Lee Len , Liu Shuang , Sambandam Aruna , Snider Patricia A. , Masih Liaqat
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
The Pyridine Analogue (II) of Diamino‐β‐isoindigo and Dinuclear Metallomacroheterocycles (III) on Its Basis
Authors: Kulikov M. A. , Berezina G. R. , Neustroeva N. R. , Borob'ev Yu. G.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Palladium‐Catalyzed Annulation of Benzene‐1,2‐diol and Racemic Secondary Propargylic Carbonates Bearing Two Different Substituents.
Authors: Dominczak Norbert , Damez Celine , Rhers Bouchra , Labrosse Jean‐Robert , Lhoste Paul , Kryczka Boguslaw , Sinou Denis
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Pyrazolo[1,5‐a]pyrimidin‐7‐yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region.
Authors: Gopalsamy Ariamala , Yang Hui , Ellingboe John W. , Tsou Hwei‐Ru , Zhang Nan , Honores Erick , Powell Dennis , Miranda Miriam , McGinnis John P. , Rabindran Sridhar K.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Reaction Between Isocyanides and Dialkyl Acetylenedicarboxylates in the Presence of 4,5‐Diphenyl‐1,3‐dihydro‐2H‐imidazol‐2‐one. One‐Pot Synthesis of 5H‐Imidazo[2,1‐b][1,3]oxazine Derivatives.
Authors: Adib Mehdi , Ghanbary Khadijeh , Mostofi Manizheh , Bijanzadeh Hamid Reza
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Inhibitors of HCV NS5B Polymerase: Synthesis and Structure—Activity Relationships of N‐1‐Heteroalkyl‐4‐hydroxyquinolon‐3‐yl‐benzothiadiazines.
Authors: Pratt John K. , et al. et al.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
1,5‐Benzodiazepines. Part 14. Synthesis of New Substituted 9H‐Bis‐[1,2,4]triazolo[4,3‐a:3′,4′.d][1,5]benzodiazepines and Related Compounds Endowed with in vitro Cytotoxic Properties.
Authors: Di Braccio Mario , Grossi Giancarlo , Ceruti Maurizio , Rocco Flavio , Loddo Roberta , Sanna Giuseppina , Busonera Bernardetta , Murreddu Marta , Marongiu Maria Elena
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and SAR of Diazepine and Thiazepine TACE and MMP Inhibitors.
Authors: Zask Arie , et al. et al.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Functionalized Azecine and Azonine Derivatives via an Enolate Assisted Aza Claisen Rearrangement.
Authors: Bremner John B. , Perkins David F.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of a Diastereomerically Pure Racemic 1,2,4‐Trioxane Dimer Related to Antiproliferative Dimers of Naturally Occurring Artemisinin.
Authors: Krasavin M. Yu. , Dorogov M. V.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Regioselective Hydrochalcogenation Reaction of 1,2‐Allenyl Phosphine Oxides: A Novel Synthesis of β‐Organochalcogenyl Allyl Phosphine Oxides.
Authors: Wu Zhimeng , Huang Xian
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Desymmetrization by Direct Cross‐Metathesis Producing Hitherto Unreachable P‐Stereogenic Phosphine Oxides.
Authors: Bisaro Fabrice , Gouverneur Veronique
Published: June 2005

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Rapid and Efficient Solid‐Supported Reagent Synthesis of Fluorine Derivatives of Phosphorus(V) Compounds.
Authors: Sierakowski Timothy , Kiddle James J.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Benzene‐1‐alanine‐3‐glycine as Carba Analogues of Cystine.
Authors: Furenes Eline Bredal , Luijendijk Jaco , Efskind Jon , Undheim Kjell
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
A γ‐Lactone Form Nafuredin, Nafuredin‐γ, also Inhibits Helminth Complex I.
Authors: Shiomi Kazuro , et al. et al.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Enantioselective Total Synthesis of Pteridic Acid A.
Authors: Nakahata Takashi , Kuwahara Shigefumi
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Mycoediketopiperazine, a Novel Fungal Metabolite from a Papularia sp.
Authors: Fang Meijuan , Fang Hua , Huang Yaojian , Zhao Yufen
Published: June 2005

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Macrolides with Promotive Activity of Monocyte to Macrophage Differentiation.
Authors: Yoshida Kiminari , Sunazuka Toshiaki , Nagai Kenichiro , Sugawara Akihiro , Cho Achim , Nagamitsu Tohru , Harigaya Yoshihiro , Otoguro Kazuhiko , Akagawa Kiyoko S. , Omura Satoshi
Published: June 2005

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Synthesis and in vitro Antitrypanosomal Activity of Novel Nifurtimox Analogues.
Authors: Pozas Rocio , Carballo Javier , Castro Clementina , Rubio Julieta
Published: June 2005

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3,4‐Disubstituted Azetidinones as Selective Inhibitors of the Cysteine Protease Cathepsin K. Exploring P3 Elements for Potency and Selectivity.
Authors: Setti Eduardo L. , Davis Dana , Janc James W. , Jeffery Douglas A. , Cheung Harry , Yu Walter
Published: June 2005

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Electron Paramagnetic Resonance Characterization of SiC
Authors: Zvanut M. F.
Published: June 2005

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Chromium, Molybdenum, and Tungsten
Authors: Matthews Craig J.
Published: June 2005

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Scandium, Yttrium, the Lanthanoids and the Actinoids
Authors: Cotton S. A.
Published: June 2005

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Ketonization of Carboxylic Acids by Decarboxylation: Mechanism and Scope
Authors: Renz Michael
Published: June 2005

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Cyclizations of Allylic Substrates via Palladium Catalysis
Authors: Hyland Christopher
Published: June 2005

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Functionalized Organolithium Compounds in Total Synthesis
Authors: Chinchilla Rafael , Najera Carmen , Yus Miguel
Published: June 2005

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Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C
Authors: Nakamura Seiichi
Published: June 2005

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Correlation Between Pressure and Steric Interactions in Organic Reactions
Authors: Jenner Gerard
Published: June 2005

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Synthesis of Modified Purine Nucleosides and Related Compounds Mediated by Adenosine Deaminase (ADA) and Adenylate Deaminase (AMPDA)
Authors: Santaniello Enzo , Ciuffreda Pierangela , Alessandrini Laura
Published: June 2005

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Mechanistic Studies in Triazolinedione ene Reactions
Authors: Vougioukalakis Georgios C. , Orfanopoulos Michael
Published: June 2005

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New Development of Photoinduced Electron Transfer Reaction and Total Synthesis of Natural Product
Authors: Hamada Tatsuo
Published: June 2005

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Retrospect of Se and Te Chemistry
Authors: Uemura Sakae
Published: June 2005

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Chalcogen Chiral Ylides for the Catalytic Asymmetric Epoxidation of Aldehydes: From Sulfur to Selenium and Tellurium
Authors: Briere Jean‐Francois , Takada Hiroya , Metzner Patrick
Published: June 2005

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First Isolation of a Novel‐Air Stable Mercury Tellurolate and the Preparation of CdS and CdSe Nanoparticles from the Respective Cadmium Chalcogenolates
Authors: Kandasamy Karuppasamy , Singh Harkesh B. , Kulshreshtha Shailendra K. , Wolmershaeuser Gotthelf
Published: June 2005

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Adverse Cardiovascular Effects of the Coxibs
Authors: Dogne Jean‐Michel , Supuran Claudiu T. , Pratico Domenico
Published: June 2005

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Asymmetric Baeyer—Villiger Oxidation: Control of Stereoelectronic Demand
Authors: Katsuki T.
Published: June 2005

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Selective Derivatization of meso‐Tetraarylporphyrins
Authors: Ostrowski Stanislaw
Published: June 2005

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Peptide Dendrimers and Other Branched Polypeptide Architectures
Authors: Klok Harm‐Anton , Rodriguez‐Hernandez Juan , Luebbert Anke
Published: June 2005

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Dioxirane Oxidation of 3β‐Substituted Δ5‐Steroids
Authors: Parish Edward J. , Qiu Zhihai
Published: June 2005

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Instant Ligand Libraries of Monodentate Phosphoramidites. Asymmetric Hydrogenation Made Easy
Authors: van den Berg Michel , Pena Diego , Minnaard Adriaan J. , Feringa Ben L. , Lefort Laurent , Boogers Jeroen A. F. , de Vries Andre H. M. , de Vries Johannes G.
Published: June 2005

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Phase Behavior and Self‐Assembly Patterns of Surfactant Mixtures in Solutions
Authors: Smirnova N. A.
Published: June 2005

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Durham Microreactors for Direct Fluorination
Authors: Chambers Richard D. , Sandford Graham
Published: June 2005

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Novel Approach to the Equation of State for Fluid Systems, Based on the Concept of the Exclusion Factor
Authors: Rusanov A. I.
Published: June 2005

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Why Enzymes Are Proficient Catalysts: Beyond the Pauling Paradigm
Authors: Zhang Xiyun , Houk K. N.
Published: June 2005

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Halogen Bonding Based Recognition Processes: A World Parallel to Hydrogen Bonding
Authors: Metrangolo Pierangelo , Neukirch Hannes , Pilati Tullio , Resnati Giuseppe
Published: June 2005

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Fifteen Years of Raman Spectroscopy of Engineered Heme Containing Peroxidases: What Have We Learned?
Authors: Smulevich Giulietta , Feis Alessandro , Howes Barry D.
Published: June 2005

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Sperm cryopreservation before cancer chemotherapy helps in the emotional battle against cancer
Authors: Saito Kazuo , Suzuki Kotaro , Iwasaki Akira , Yumura Yasushi , Kubota Yoshinobu
Published: June 2005

BACKGROUND

Sperm cryopreservation before cancer chemotherapy is available for young patients with cancer. However, few patients bank their sperm. The authors evaluated by questionnaire the psychological impact of sperm cryopreservation.

METHODS

The authors cryopreserved the sperm of 111 patients with cancer for free at the Yokohama City University (Yokohama, Japan). For the current study, questionnaires were mailed to 66 patients whose sperm had been cryopreserved. Fifty‐one patients (77.3%) with testicular carcinomas (n = 24), leukemia or malignant lymphoma (n = 19), or other cancers (n = 8) answered the questionnaire. The average age at collection and the period of sperm cryopreservation were 30.1 ± 6.0 (mean ± standard deviation) and 3.3 ± 2.2 years, respectively.

RESULTS

Many patients were informed of the deleterious effects of cancer chemotherapy and worried about infertility in the future. However, only half of the patients banked their sperm on their own initiative. Other patients followed their physician's instruction. Eighty percent of patients replied that sperm cryopreservation helped in the battle against cancer.Sperm banking especially was found to encourage every patient who banked sperm on their own initiative. After cancer chemotherapy, 70% of patients wanted to have a child. However, 60% of patients were worried about infertility in spite of having their sperm cryopreserved. No patients wanted to use cryopreserved sperm for fathering children if their spermatogenesis was restored. Sperm cryopreservation invigorated many patients with cancer after cancer treatments. The majority of patients recommended sperm cryopreservation to other cancer patients.

CONCLUSIONS

Sperm cryopreservation encouraged young patients with cancer during and after cancer treatment. It should be recommended for all young patients with cancer. However, sperm cryopreservation did not eliminate their fear of infertility. Cancer 2005. © 2005 American Cancer Society.
S100β as a predictor of brain metastases
Authors: Vogelbaum Michael A. , Masaryk Thomas , Mazzone Peter , Mekhail Tarek , Fazio Vincent , McCartney Sally , Marchi Nicola , Kanner Andrew , Janigro Damir
Published: June 2005

BACKGROUND

The identification of brain metastases in patients with malignant disease has important implications for determining their treatment and prognosis. Asymptomatic metastatic brain tumors may be detected by surveillance imaging techniques, but longitudinal follow‐up of patients who are at risk is sporadic primarily due to cost. Because the development of brain metastases is accompanied and detected by extravasation of contrast agents across the blood‐brain barrier (BBB), the authors hypothesized that peripheral analysis of the BBB indicator S100β may be useful as a screening tool for brain metastases in patients who have no neurologic symptoms.

METHODS

Thirty‐eight patients were enrolled for the current study. All patients had newly diagnosed lung carcinoma and had no neurologic symptoms or known history of brain metastasis. Patients underwent an initial magnetic resonance imaging (MRI) scans and S100β blood tests. S100β tests were repeated in a subset of patients at the time of routine follow‐up MRI scans.

RESULTS

Based on imaging studies and on serum S100β analyses, the patients were divided in 3 categories: 1) patients with normal S100β levels (0.08 ± 0.02 μg/L;n= 22 patients) and normal MRI scans; 2) patients with elevated S100β levels (0.5 ± 0.28 μg/L;n= 8 patients) and pronounced microvascular changes on MRI scans but with no metastases; and 3) patients with elevated S100β levels (0.28 ± 0.19 μg/L;n= 7 patients) and metastatic brain tumor(s) on MRI scans.

CONCLUSIONS

Because of the significant overlap in S100β levels between patients with cerebral microvascular diseases and patients with brain metastases, the authors concluded that the serum S100β level may be used as a surveillance tool to predict or detect brain metastases if appropriate prescreening radiologic tests are obtained and if patients who are candidates for false‐positive results are identified and excluded. Cancer 2005. © 2005 American Cancer Society.
Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma
Authors: Casson Alan G. , Zheng Zuoyu , Evans Susan C. , Geldenhuys Laurette , van Zanten Sander Veldhuyzen , Veugelers Paul J. , Porter Geoffrey A. , Guernsey Duane L.
Published: June 2005

BACKGROUND

To investigate individual susceptibility to gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma, the authors studied the frequency of the common G870A polymorphism of CCND1, which encodes cyclin D1, a key cell cycle regulatory protein.

METHODS

The study population included 307 patients who were enrolled in a prospective case–control study to evaluate lifestyle risk factors and molecular alterations in gastroesophageal reflux disease (n = 126 patients), Barrett esophagus (n = 125 patients), and esophageal adenocarcinoma (n = 56 patients). A control group included 95 strictly asymptomatic individuals. Genomic DNA was extracted from cases and controls, and polymerase chain reaction was used to amplify exon 4 of CCND1. After digestion with BsrI, acrylamide gel electrophoresis was used to identify the wild type and common G870A polymorphic alleles. The frequency of alleles (G/G, G/A, A/A) was compared between cases and controls. Immunohistochemistry was used to study cyclin D1 distribution in among patients in the case group.

RESULTS

Compared with the asymptomatic control group, and adjusted for age and gender, increasing frequencies were seen for the A/A genotype in patients with gastroesophageal reflux disease (odds ratio [OR], 2.83; 95% confidence interval [95% CI], 1.09–7.34), Barrett esophagus (OR, 3.69; 95% CI, 1.46–9.29), and esophageal adenocarcinoma (OR, 5.99; 95% CI, 1.86–18.96). No association was seen between genotype and cyclin D1 overexpression.

CONCLUSIONS

The CCND1 A/A genotype was associated with increased risk for gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma. The contribution of this polymorphism to susceptibility of defined stages of progression to esophageal adenocarcinoma suggested potential application in endoscopic Barrett surveillance programs. Cancer 2005. © 2005 American Cancer Society.
Effect of neutropenia on the impact of a cognitive‐behavioral intervention for symptom management
Authors: Given Barbara A. , Given Charles W. , Jeon Sanchoon , Sikorskii Alla
Published: June 2005

BACKGROUND

Trials of cognitive‐behavioral interventions (CBI) designed to reduce symptom severity or improve dimensions of quality of life seldom consider how the side effects of treatment or the complications imposed by the disease or treatment may moderate the impact of the trial on the designated outcome. To address this issue, the moderating effect of neutropenia on the impact of a CBI for reducing symptom severity was evaluated among patients with cancer undergoing chemotherapy.

METHODS

The authors described the impact of a randomized trial of a 10‐contact, 20‐week CBI on symptom severity, as well as the moderating effect of a neutropenic episode on symptom severity at 20 weeks. Severity scores were based on sum scores (0–10) for 15 symptoms.

RESULTS

There was an effect for age (younger) and group on severity at 20 weeks and an interaction between neutropenia and group. Among patients with no evidence of neutropenia, those in the experimental arm had a 9‐point lower severity score at 20 weeks. Among patients who experienced neutropenia, differences in symptom severity by arm of the trial were < 3 points. Further, fatigue, fever, and pain were more prevalent among patients with neutropenia.

CONCLUSIONS

Patients who experienced neutropenia did not benefit from a CBI to lower symptoms. The overall effect of this intervention came almost exclusively from patients without neutropenia. Cancer 2005. © 2005 American Cancer Society.
Adsorption of [D2]Methanol on Ru(001)O Surfaces: The Influence of Preadsorbed Oxygen on the Methoxide Geometry
Authors: Barros Ricardo B. , Garcia Ana Rosa , Ilharco Laura M.
Published: June 2005

The influence of oxygen precoverage on the bonding geometry of methoxide on Ru(001) was studied using the isotopically labeled molecule CHD2OH by reflection–absorption infrared spectroscopy (RAIRS). This molecule is an excellent model because the vibrational spectra of CHD2O− may be unambiguously correlated with the adsorption configuration. For Ru(001)O layers with an effective oxygen coverage (θ0) between 0.25 and 0.6 ML (ML=monolayer), the influence of the oxygen precoverage was shown to vary with the initial methanol exposure. For an extremely low dose of [D2]methanol (0.01 L; L=Langmuir, 1 L=10−6 torr s), at 90 K, no oxygen‐coverage effects were detected on the geometry of [D2]methoxide: it adsorbs in an upright orientation (pseudo‐C3v local symmetry), just as on clean Ru(001). An increase in the methanol exposure to 0.1 L, at the same temperature, results in the formation of a disordered layer of tilted methoxide: for θO=0.25 ML, Cs/C1 and intrinsic C1 configurations are present on the surface, whereas for θO≥0.5 ML, only the former species were identified. The thermal activation of these tilted layers to 105 K results in a lower coverage of upright methoxide for any oxygen precoverage, coadsorbed with decomposition products, as confirmed by the detection of adsorbed formaldehyde and, on the denser oxygen layer (θO=0.6 ML), formate. The influence of the oxygen precoverage becomes determinant when annealing a [D2]methanol multilayer to 105 K: for θO=0.25 ML, the RAIR spectrum correlates with a disordered layer of tilted methoxide and formaldehyde, whereas for θO=0.6 ML upright methoxide, formate, and carbon monoxide were identified. On clean Ru(001), for methanol exposures ≥0.1 L, the C3v methoxide configuration was never attained upon thermal activation.
Radiolysis of Confined Water: Molecular Hydrogen Formation
Authors: Rotureau P. , Renault J. P. , Lebeau B. , Patarin J. , Mialocq J.‐C.
Published: June 2005

The formation of molecular hydrogen in the radiolysis of water confined in nanoscale pores of well‐characterised porous silica glasses and mesoporous molecular sieves (MCM‐41) is examined. The comparison of dihydrogen formation by irradiation of both materials, dry and hydrated, shows that a large part of the H2 comes from the surface of the material. The radiolytic yields, G(H2)=(3±0.5)×10−7 mol J−1, calculated using the total energy deposited in the material and the water, are only slightly affected by the degree of hydration of the material and by the pore size. These yields are also not modified by the presence of hydroxyl radical scavengers. This observation proves that the back reaction between H2 and HO. is inoperative in such confined environments. Furthermore, the large amount of H2 produced in the presence of different concentrated scavengers of the hydrated electron and its precursor suggests that these two species are far from being the only species responsible for the H2 formation.

Our results show that the radiolytic phenomena that occur in water confined in nanoporous silica are dramatically different to those in bulk water, suggesting the need to investigate further the chemical reactivity in this type of environment.