bluuebunny/crossref_metadata_2025 huggingface dataset:
Citalopram-induced sleep bruxism in a breastfed infant: A case report
Authors: Akbarzadeh Farzad , Behravan Ghazal , Modaresi Farzaneh , Eslamzadeh Mahboubeh
Published: February 2023

Bruxism associated with antidepressant use is an under-recognized phenomenon. The use of citalopram has gained wide acceptance in the treatment of depression and anxiety disorders; however, the consumption of this medication during lactation and pregnancy has not been carefully characterized. There are limited studies about its side effects in the breastfeeding period. Here, we report a rare case of citalopram-induced sleep bruxism in a 9-month-old female breastfed infant whose mother used SSRI agent citaloporm for her anxiety disorder. Within 2 weeks of initiating her citalopram treatment, with a starting dose of 10 mg/day, the patient reported sleep bruxism in her infant. Thorough examinations of the infant were performed and no abnormal finding was reported. After ruling out other possible causes, the new-onset bruxism symptoms were attributed to the mother’s recent use of citalopram, which was discontinued thereafter. The infant’s symptoms of bruxism disappeared following the discontinuation of the medication by her mother. These findings and similar reports could draw more attention to bruxism or other possible symptoms in breastfed infants of mothers consuming psychotropic medications.
Modeling disease progression and treatment pathways for depression jointly using agent based modeling and system dynamics
Authors: Brice Syaribah N. , Harper Paul R. , Gartner Daniel , Behrens Doris A.
Published: February 2023

Introduction

Depression is a common mental health condition that affects millions of people worldwide. Care pathways for depression are complex and the demand across different parts of the healthcare system is often uncertain and not entirely understood. Clinical progression with depression can be equally complex and relates to whether or not a patient is seeking care, the care pathway they are on, and the ability for timely access to healthcare services. Considering both pathways and progression for depression are however rarely studied together in the literature.

Methods

This paper presents a hybrid simulation modeling framework that is uniquely able to capture both disease progression, using Agent Based Modeling, and related care pathways, using a System Dynamics. The two simulation paradigms within the framework are connected to run synchronously to investigate the impact of depression progression on healthcare services and, conversely, how any limitations in access to services may impact clinical progression. The use of the developed framework is illustrated by parametrising it with published clinical data and local service level data from Wales, UK.

Results and discussion

The framework is able to quantify demand, service capacities and costs across all care pathways for a range of different scenarios. These include those for varying service coverage and provision, such as the cost-effectiveness of treating patients more quickly in community settings to reduce patient progression to more severe states of depression, and thus reducing the costs and utilization of more expensive specialist settings.
Liver injury associated with the severity of COVID-19: A meta-analysis
Authors: Yang Ruiqi , Feng Jihua , Wan Huan , Zeng Xiaona , Ji Pan , Zhang Jianfeng
Published: February 2023

Background

The current 2019 novel coronavirus disease (COVID-19) pandemic is a major threat to global health. It is currently uncertain whether and how liver injury affects the severity of COVID-19. Therefore, we conducted a meta-analysis to determine the association between liver injury and the severity of COVID-19.

Methods

A systematic search of the PubMed, Embase, and Cochrane Library databases from inception to August 12, 2022, was performed to analyse the reported liver chemistry data for patients diagnosed with COVID-19. The pooled odds ratio (OR), weighted mean difference (WMD) and 95% confidence interval (95% CI) were assessed using a random-effects model. Furthermore, publication bias and sensitivity were analyzed.

Results

Forty-six studies with 28,663 patients were included. The pooled WMDs of alanine aminotransferase (WMD = 12.87 U/L, 95% CI: 10.52–15.23, I2 = 99.2%), aspartate aminotransferase (WMD = 13.98 U/L, 95% CI: 12.13–15.83, I2 = 98.2%), gamma-glutamyl transpeptidase (WMD = 20.67 U/L, 95% CI: 14.24–27.10, I2 = 98.8%), total bilirubin (WMD = 2.98 μmol/L, 95% CI: 1.98–3.99, I2 = 99.4%), and prothrombin time (WMD = 0.84 s, 95% CI: 0.46–1.23, I2 = 99.4%) were significantly higher and that of albumin was lower (WMD = −4.52 g/L, 95% CI: −6.28 to −2.75, I2 = 99.9%) in severe cases. Moreover, the pooled OR of mortality was higher in patients with liver injury (OR = 2.72, 95% CI: 1.18–6.27, I2 = 71.6%).

Conclusions

Hepatocellular injury, liver metabolic, and synthetic function abnormality were observed in severe COVID-19. From a clinical perspective, liver injury has potential as a prognostic biomarker for screening severely affected patients at early disease stages.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, Identifier: CRD42022325206.
Design and psychometric properties of the family support for older people questionnaire
Authors: Shamsikhani Soheila , Ahmadi Fazlollah , Kazemnejad Anoshirvan , Vaismoradi Mojtaba
Published: February 2023

Background and objectives

The population of older people is increasing across the world. Older people need care and support from their families to be able to live independently. This study aimed to design and evaluate the psychometric properties of the family support for older people (FSOP) questionnaire.

Methods

In this instrument development study using a mixed-methods design, the psychometric properties of the FSOP questionnaire in terms of validity and reliability were evaluated.

Results

The FSOP questionnaire consisted of 50 items in six domains. It was shown to have appropriate qualitative and quantitative validities (score > 1.5). The indicators of content validity (CVR > 0.62, ICVI ≥ 0.80, and SCVI > 0.94) and confirmatory factor analysis (indexes of χ2/df = 2.50, CFI = 0.96, GFI = 0.97, AGFI = 0.96, NNFI = 0.96, PNFI = 0.89, TLI = 0.96, and RMSEA = 0.06) were satisfactory. Cronbach's alpha coefficient for reliability was 0.94, indicating an optimal score.

Conclusions

Healthcare providers and family caregivers are suggested to use the FSOP questionnaire for improving the quality of life of older people at home.
Analyzing the efficiency of Chinese primary healthcare institutions using the Malmquist-DEA approach: Evidence from urban and rural areas
Authors: Zhou Junxu , Peng Rong , Chang Yajun , Liu Zijun , Gao Songhui , Zhao Chuanjun , Li Yixin , Feng Qiming , Qin Xianjing
Published: February 2023

Background

China has been increasing the investment in Primary Health Care Institutions (PHCIs) since the launch of the New Health Care System Reform in 2009. It is a crucial concern whether the PHCIs can meet residents' need both in urban and rural with the limited government finance, especially encountering the challenge of the COVID-19. This study aimed to reveal the trend of the primary health service efficiency in the past decade, compare the urban-rural differences, and explore relevant factors.

Methods

DEA and Malmquist models were applied to calculate the health service efficiency of PHCIs among 28 provinces in China, with the input variables including the number of institutions, number of beds, number of health technicians, and the outputs variables including the number of outpatients and emergency visits, number of discharged patients. And the Tobit model was used to analyze the factors on the efficiency in urban and rural. A sensitivity analysis for model validations was also carried out.

Results

The average technical efficiency (TE) of urban PHCIs fluctuated from 63.3% to 67.1%, which was lower than that in rural (75.8–82.2%) from 2009 to 2019. In terms of dynamic efficiency, the urban PHCIs performed better than the rural, and the trends in the total factor productivity change were associated with favorable technology advancement. The population density and dependency ratio were the key factors on TE in both of the urban and rural PHCIs, and these two factors were positively correlated to TE. In terms of TE, it was negatively correlated with the proportion of total health expenditure as a percentage of GDP in urban PHCIs, while in rural it was positively correlated with the urbanization rate and negatively correlated with GDP per capita. Besides, the tests of Mann–Whitney U, and Kruskal–Wallis H indicated the internal validity and robustness of the chosen DEA and Malmquist models.

Conclusions

It needs to reduce the health resource wastes and increase service provision in urban PHCIs. Meanwhile, it is necessary to strengthen medical technology and gaining greater efficiency in rural PHCIs by technology renovation.
Hospital efficiency in the eastern mediterranean region: A systematic review and meta-analysis
Authors: Ravaghi Hamid , Afshari Mahnaz , Isfahani Parvaneh , Mahboub-Ahari Alireza , Bélorgeot Victoria D.
Published: February 2023

Background

Recent rising costs and shortages of healthcare resources make it necessary to address the issue of hospital efficiency. Increasing the efficiency of hospitals can result in the better and more sustainable achievement of their organizational goals.

Objective

The purpose of this research is to examine hospital efficiency in the Eastern Mediterranean Region (EMR) using data envelopment analysis (DEA).

Methods

This study is a systematic review and meta-analysis of all articles published on hospital efficiency in Eastern Mediterranean countries between January 1999 and September 2020, identified by searching PubMed through MEDLINE, Web of Science, Scopus, Science Direct, and Google Scholar. The reference lists of these articles were checked for additional relevant studies. Finally, 37 articles were selected, and data were analyzed through Comprehensive Meta-Analysis Software (v.2.2.064).

Results

Using the random-effects model, the mean hospital efficiency in Eastern Mediterranean hospitals was 0.882 ± 0.01 at 95% CI. Technical efficiency (TE) was higher in some countries such as Iraq (0.976 ± 0.035), Oman (0.926 ± 0.032), and Iran (0.921 ±0.012). A significant statistical correlation was observed between the hospital efficiency and the year of publication and sample size (p < 0.05).

Conclusion

Efficiency plays a significant role in hospital growth and development. Therefore, it is important for healthcare managers and policymakers in the EMR to identify the causes of inefficiency, improve TE, and develop cost-effective strategies.
Performance of the nontreponemal tests and treponemal tests on cerebrospinal fluid for the diagnosis of neurosyphilis: A meta-analysis
Authors: Xie Jia-Wen , Wang Mao , Zheng Ya-Wen , Lin Yong , He Yun , Lin Li-Rong
Published: February 2023

Background

Nontreponemal and treponemal tests for analyzing cerebrospinal fluid to confirm the existence of neurosyphilis have been widely used, so we aim to evaluate and compare their performance on the cerebrospinal fluid in the diagnosis of neurosyphilis.

Methods

We conducted a systematic literature search on five databases and utilized a bivariate random-effects model to perform the quantitative synthesis.

Results

Nontreponemal tests demonstrated a pooled sensitivity of 0.77 (95% CI: 0.68–0.83), a pooled specificity of 0.99 (95% CI: 0.97–1.00), and a summary AUC of 0.97 (95% CI: 0.95–0.98). The pooled sensitivity, pooled specificity, and summary AUC of treponemal tests were 0.95 (95% CI: 0.90–0.98), 0.85 (95% CI: 0.67–0.94), and 0.97 (95% CI: 0.95–0.98), respectively. The pooled specificity of all nontreponemal tests varied minimally (ranging from 0.97 to 0.99), with TRUST (0.83) having a higher pooled sensitivity than VDRL (0.77) and RPR (0.73). Among all treponemal tests, EIA has outstanding diagnostic performance with a pooled sensitivity of 0.99 and a pooled specificity of 0.98.

Conclusion

Nontreponemal tests exhibited a higher pooled specificity, and treponemal tests exhibited a higher pooled sensitivity in diagnosing neurosyphilis on cerebrospinal fluid. TRUST may be a satisfactory substitute for VDRL. EIA is a prospective diagnostic tool that deserves further study in the future. Our study may be useful to clinical laboratories in selecting appropriate serological tests on the cerebrospinal fluid for the diagnosis of neurosyphilis.
Maternal age at childbirth and the risk of attention-deficit/hyperactivity disorder and learning disability in offspring
Authors: Gao Ling , Li Songtao , Yue Yulin , Long Guangfeng
Published: February 2023

Background

Studies have shown that young maternal age at childbirth can increase the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring, but a study of the U.S. population has not been reported. Moreover, there is no reported research on young and advanced maternal age at childbirth and whether it can contribute to the risk of learning disability (LD) in offspring.

Methods

This study evaluated the association between young and advanced maternal age at childbirth and offspring risk of ADHD and LD in the U.S. population. Using data from 8,098 participants included in the National Health and Nutrition Examination Survey (NHANES) conducted in 1999–2004, we analyzed the association between maternal age at childbirth and ADHD and LD risk in offspring. Odds ratios (ORs) and 95% confidence intervals (CIs) for maternal age at childbirth in association with ADHD and LD risk in offspring were estimated using multivariate logistic regression models after adjustment for age, sex, race, body mass index (BMI), poverty income ratio, smoking status during pregnancy, and NHANES cycle. Restricted cubic spline (RCS) models were used to evaluate potential non-linear relationships. Sensitivity analyses were performed to ensure the reliability of the results.

Results

Among all participants, the offspring of subjects with a maternal age at childbirth of 18–24 years had an increased risk of ADHD (OR = 1.34, 95% CI: 1.01, 1.79) and LD (OR = 1.36, 95% CI: 1.06, 1.79) or either ADHD or LD (OR = 1.48, 95% CI: 1.20, 1.81). Additionally, compared with subjects with a maternal age at childbirth of 25–29 years, subjects with a maternal age at childbirth of 35–39 years had lower odds of having offspring with ADHD (OR = 0.60, 95% CI: 0.36, 1.00) and higher odds of having offspring with LD (OR = 1.34, 95% CI: 1.01, 1.78). The relationship between maternal age at childbirth and LD risk presented a U-shaped curve.

Conclusions

These results provide epidemiological evidence showing that young and advanced maternal age at childbirth are associated with ADHD and LD risk.
Being friendly to the skin microbiome: Experimental assessment
Authors: van Belkum Alex , Lisotto Paola , Pirovano Walter , Mongiat Sebastien , Zorgani Amine , Gempeler Mathias , Bongoni Radhika , Klaassens Eline
Published: February 2023

Both academia and dermatological and cosmetic industries have acknowledged that healthy skin microbiota contribute to overall skin integrity and well-being. This implies that formulations developed for personal care (skin, scalp, hair etc) or (medical and cosmetic) treatment need to be compatible with microbiota conservation or possibly even improvement. The various chemical and biological components and mixtures thereof intended for direct application to the skin should not extensively affect the qualitative and quantitative composition of the skin microbiota. A compound should promote beneficial microbes and inhibit pathogens. Compounds but also final products could be considered at least theoretically “microbiome friendly” while in some cases changes to the microbiota may even be considered beneficial. An important hurdle lies in the practical and methodological approaches to be used for defining microbiota inertia of compounds and formulations. Clear guidelines for assessing microbiome friendliness are lacking. We propose three testing concepts that may help to define microbiome friendliness based on the assessment of minimal microbiota perturbation and possibly elimination of potential pathogens. Methods to prove microbiome friendliness should ultimately be based upon (metagenomic rather than amplicon-based) next generation sequencing of naive versus compound- or final product-exposed skin microbiota in vivo, but preferably also including in vitro and ex vivo pre-screening methodologies to build an understanding of their consequences. As in many domains of microbiome research, the development of experimental process controls and internal standards, which are essentially lacking to date, should be taken as a future prerequisite. There is also a requirement from regulatory agencies to define and harmonize acceptance criteria.
Why Do Marine Mammals Strand on Land and How Can Humans Help?
Authors: Boys Rebecca M. , Stockin Karen A. , Peters Katharina J.
Published: February 2023

Have you ever heard about, or maybe even seen, a whale or a dolphin that was helplessly lying on the beach or stuck in very shallow water? These are called “stranding events” or “strandings,” and have been documented since the fourth century. Back then, strandings involving cetaceans (whales, dolphins, and porpoises) were welcome events because they provided a rich source of food and other resources for the people nearby. But today, we tend to see strandings as events in which animals need human help. There are several types of strandings, each with their own possible causes. In this article, we explain what stranding events are, what might cause them, and how you can help if you ever find a stranded animal.
Non-thermal broadening of IRIS Fe XXI line caused by turbulent plasma flows in the magnetic reconnection region during solar eruptions
Authors: Shen Chengcai , Polito Vanessa , Reeves Katharine K. , Chen Bin , Yu Sijie , Xie Xiaoyan
Published: February 2023

Magnetic reconnection is the key mechanism for energy release in solar eruptions, where the high-temperature emission is the primary diagnostic for investigating the plasma properties during the reconnection process. Non-thermal broadening of high-temperature lines has been observed in both the reconnection current sheet (CS) and flare loop-top regions by UV spectrometers, but its origin remains unclear. In this work, we use a recently developed three-dimensional magnetohydrodynamic (MHD) simulation to model magnetic reconnection in the standard solar flare geometry and reveal highly dynamic plasma flows in the reconnection regions. We calculate the synthetic profiles of the Fe XXI 1354 Å line observed by the Interface Region Imaging Spectrograph (IRIS) spacecraft by using parameters of the MHD model, including plasma density, temperature, and velocity. Our model shows that the turbulent bulk plasma flows in the CS and flare loop-top regions are responsible for the non-thermal broadening of the Fe XXI emission line. The modeled non-thermal velocity ranges from tens of km s−1 to more than two hundred km s−1, which is consistent with the IRIS observations. Simulated 2D spectral line maps around the reconnection region also reveal highly dynamic downwflow structures where the high non-thermal velocity is large, which is consistent with the observations as well.
Artificial lamina after laminectomy: Progress, applications, and future perspectives
Authors: Yue Jing , Han Qing , Chen Hao , Zhang Aobo , Liu Yang , Gong Xuqiang , Wang Yang , Wang Jincheng , Wu Minfei
Published: February 2023

In clinical practice, laminectomy is a commonly used procedure for spinal decompression in patients suffering from spinal disorders such as ossification of ligamentum flavum, lumbar stenosis, severe spinal fracture, and intraspinal tumors. However, the loss of posterior column bony support, the extensive proliferation of fibroblasts and scar formation after laminectomy, and other complications (such as postoperative epidural fibrosis and iatrogenic instability) may cause new symptoms requiring revision surgery. Implantation of an artificial lamina prosthesis is one of the most important methods to avoid post-laminectomy complications. Artificial lamina is a type of synthetic lamina tissue made of various materials and shapes designed to replace the resected autologous lamina. Artificial laminae can provide a barrier between the dural sac and posterior soft tissues to prevent postoperative epidural fibrosis and paravertebral muscle compression and provide mechanical support to maintain spinal alignment. In this paper, we briefly review the complications of laminectomy and the necessity of artificial lamina, then we review various artificial laminae from clinical practice and laboratory research perspectives. Based on a combination of additive manufacturing technology and finite element analysis for spine surgery, we propose a new designing perspective of artificial lamina for potential use in clinical practice.
The paradox of Zeno in bariatric surgery weight loss: Superobese patients run faster than morbidly obese patients, but can't overtake them
Authors: Medas Fabio , Moroni Enrico , Deidda Simona , Zorcolo Luigi , Restivo Angelo , Canu Gian Luigi , Cappellacci Federico , Calò Pietro Giorgio , Pintus Stefano , Fantola Giovanni
Published: February 2023

Introduction

Superobesity (SO) is defined as a BMI > 50 Kg/m2, and represents the extreme severity of the disease, resulting in a challenge for the surgeons.

Methods

In this retrospective study we aimed to compare the outcomes of SO patients compared to morbidly obese (MO) patients.

Results

We included in this study 154 MO patients, with a median preoperative BMI of 40.8 kg/m2, and 19 SO patients with median preoperative BMI of 54.9 kg/m2. The MO patients underwent sleeve gastrectomy (SG) in 62 (40.3%) cases, laparoscopic Roux-and-Y gastric bypass (LRYGBP) in 85 (55.2%) cases and One-Anastomosis Gastric Bypass (OAGB) in 7 (4.5%) cases. underwent OAGB. The patients in the SO group were submitted to SG in 11 (57.9%) cases, LRYGBP in 5 (26.3%) cases, and OAGB in 3 (15.8%). At 24-month follow-up, an excess weight loss (EWL) >50% was achieved in 129 (83.8%) patients in the MO group and in 15 (78.9%) in the SO group (p = 0.53). A BMI < 35 kg/m2 was achieved in 137 (89%) patients in the MO group and from 8 (42.2%) patients in the SO group (p < 0.001). The total weight loss was significantly directly related to the initial BMI. Superobesity was identified as independent risk factor for surgical failure when considering the outcome of BMI < 35 kg/m2.

Discussion

Our study confirms that, although SO patients tend to gain a greater weight loss than MO patients, they less frequently achieve the desired BMI target. In this setting, it should be necessary to re-consider malabsorptive procedures as first choice.
“The Yak”—A remarkable animal living in a harsh environment: An overview of its feeding, growth, production performance, and contribution to food security
Authors: Shah Ali Mujtaba , Bano Iqra , Qazi Izhar Hyder , Matra Maharach , Wanapat Metha
Published: February 2023

Yaks play an important role in the livelihood of the people of the Qinghai-Tibet Plateau (QTP) and contribute significantly to the economy of the different countries in the region. Yaks are commonly raised at high altitudes of ~ 3,000–5,400 m above sea level. They provide many important products, namely, milk, meat, fur, and manure, as well as social status, etc. Yaks were domesticated from wild yaks and are present in the remote mountains of the QTP region. In the summer season, when a higher quantity of pasture is available in the mountain region, yaks use their long tongues to graze the pasture and spend ~ 30–80% of their daytime grazing. The remaining time is spent walking, resting, and doing other activities. In the winter season, due to heavy snowfall in the mountains, pasture is scarce, and yaks face feeding issues due to pasture scarcity. Hence, the normal body weight of yaks is affected and growth retardation occurs, which consequently affects their production performance. In this review article, we have discussed the domestication of yaks, the feeding pattern of yaks, the difference between the normal and growth-retarded yaks, and also their microbial community and their influences. In addition, blood biochemistry, the compositions of the yaks' milk and meat, and reproduction are reported herein. Evidence suggested that yaks play an important role in the daily life of the people living on the QTP, who consume milk, meat, fur, use manure for fuel and land fertilizer purposes, and use the animals for transportation. Yaks' close association with the people's well-being and livelihood has been significant.
Norecopa: A global knowledge base of resources for improving animal research and testing
Authors: Smith Adrian J.
Published: February 2023

There are good ethical, legal and scientific reasons for ensuring that our use of animals in research and testing is limited to the lowest number of animals, and that those which are used are treated as humanely as possible, while at the same time providing reliable, reproducible and translatable data which is adequately reported. Unfortunately, there is widespread evidence that there is room for improvement in all these areas. This paper describes the Norecopa website, which offers links to global resources which can be used to resolve these issues. Much of the website content is linked to the PREPARE guidelines for planning any research or testing which appears to need animals. Attention to detail on all steps of the pathway from early planning to manuscript submission should lead to better science, improved animal welfare, and fewer health and safety accidents. This will also minimize the chances of manuscript rejection due to inadequate planning, avoiding a waste of human resources and animal lives.
Implementing Screening, Brief Intervention and Referral Intervention for Health Promotion and Disease Prevention in Hospital Settings in Alberta: A Pilot Study
Authors: Adhikari Kamala , Kashif Mughal Muhammad , Whitworth James , Bischoff Madison , Teare Gary F.
Published: February 2023

Objective: This study assessed the feasibility of implementing screening, brief intervention and referral (SBIR) intervention in hospital settings.

Methods: This cross-sectional study evaluated the implementation of the SBIR intervention in a hospital in Alberta for tobacco use, alcohol intake, physical inactivity, and insufficient vegetable and fruit consumption. Patients were interviewed approximately 4-month later to collect data on the acceptability and effectiveness of the intervention received (n = 108). The data were primarily analyzed using descriptive statistics.

Results: Of 108 patients, >80% agreed that “they were ok with being screened” for the risk factors during their hospital visit. Up to 68% of patients recalled the provider’s brief education. At the follow-up, 20% of patients quit tobacco, 50% reduced alcohol use, 30% increased physical activity, and 25% increased vegetable and fruit intake.

Conclusion: Risk factor screening was acceptable for patients. Patients recalled the brief education they received from healthcare providers. Patients reported risk-reducing changes in their risk factors. Our future work will integrate the SBIR approach within the Electronic Clinical Information System and use robust research methods to investigate the impact of SBIR on patients’ behavior change.
Reference Data on the Normal Abdominal Wall Anatomy and Baseline Characteristics in Seventy-One Nulliparous Women
Authors: Woxnerud K. , Sandblom G. , Hedbeck C. , Olsson A.
Published: February 2023

Aims: The aim of this study was to describe the prepartum anatomy of the abdominal wall in a cohort of nulliparous women, for use as a reference for management of patients with postpartum abdominal wall insufficiency with or without rectus diastasis.

Materials and Methods: Seventy-one women were examined with ultrasonography of the abdominal wall. The inter-recti distance (IRD), anatomical variations of the linea semilunaris, and the oblique muscles were assessed. The waistline was measured during activation and relaxation of the abdominal core. Participant characteristics were registered. Questionnaires regarding habitual physical activity (Baecke), low back pain (Oswestry), physical functioning (DRI), urinary incontinence (UDI-6 and IIQ-7), and quality-of-life (SF-36) were answered.

Results: Mean age was 30.5 years (range 19–50 years) and mean BMI 23.5 kg/m2 (range 18–37). Ultrasonography showed a mean IRD of 10 mm (range 3–24) at the superior border of the umbilicus, 9 mm (4–20) 3 cm above the umbilicus, and 2 mm (−5–10) 2 cm below the umbilicus. The mean thickness of the linea alba was 3 mm (1.5–5) and mean distances between the lateral edge of the rectus muscle and the external, internal, and transverse oblique muscles were 12 mm (−10–28), 1 mm (−14–13) and 15 mm (−14–32) at umbilicus level. Responses to the DRI, UDI-6, IIQ-7 and Oswestry questionnaires showed generally lower scores than the normal population whereas Baecke and SF-36 scores were similar.

Conclusion: This study provides baseline data on normal abdominal wall anatomy in a healthy nulliparous female cohort, as well as levels of activity, physical function, disability, and quality-of-life.
Fractional Derivative Viscosity of ANCF Cable Element
Authors: Gu Yaqi , Yu Zuqing , Lan Peng , Lu Nianli
Published: February 2023

Typical engineering cable structures, such as high-voltage wire and wire rope, usually bring a damping effect which cannot be ignored due to the technological problems of manufacturing. For such problems, especially the damping of cable structures undergoing large displacement and severe deformation, few studies have been reported in the past. In this work, the fractional derivative viscosity model is introduced into the cables described by the absolute nodal coordinate formulation. The computer implementation algorithm of the proposed cable damping model is given based on the three-parameter fractional derivative model. Two numerical examples demonstrate the effectiveness and convergence property of the proposed cable damping model. An experiment is proposed in which a wire is tensioned and released. Configurations are captured by the high-speed camera and compared with the results obtained from the numerical simulation. The agreement of the simulation and experimental results validates the proposed cable damping in application.
Resilience in Food Systems: Concepts and Measurement Options in an Expanding Research Agenda
Authors: Roosevelt Megan , Raile Eric D. , Anderson Jock R.
Published: February 2023

The idea of “resilience” increasingly appears in development dialogue and discussion of food systems. While the academic concept of resilience has roots in diverse disciplines, climate change and the coronavirus disease 2019 (COVID-19) pandemic have led to a rapid intensification of interest in the concept as it applies to food systems. Both the broad conceptual roots and the swift increase in attention pose dangers of conceptual dilution, contradiction, and confusion as agronomists and other analysts of food systems incorporate the resilience concept into their work. In this publicly funded research, the authors present the results of an extensive search of literature and subsequent analysis. The overview examines conceptualizations of resilience more broadly, followed by a similar review within the food systems domain. The authors consider connections among related concepts under the broader umbrella of food security, such as vulnerability and risk, and discuss challenges and opportunities in the investigation of food system resilience. The review of concepts serves as a precursor to an investigation of measurement options in a rapidly expanding body of empirical research, as measurement should flow clearly from conceptualization. The analysis here presents various resilience measures at different levels and breaks down their components as they apply to food systems, identifying commonalities and divergences. The authors identify a glut of resilience conceptualizations and measurements but indicate avenues for consolidation and precision. The range of options means that researchers can likely find suitable existing subconcepts and measurements for their own work across many different types of shocks. The authors also discuss policy and practical applications, including connections to the United Nations’ Sustainable Development Goals and food system responses to climate change and pandemics.
Does Drone Data Allow the Assessment of Phosphorus and Potassium in Soil Based on Field Experiments with Winter Rye?
Authors: Mazur Piotr , Gozdowski Dariusz , Stępień Wojciech , Wójcik-Gront Elżbieta
Published: February 2023

The evaluation of the nutrient content in the soil, such as potassium and phosphorus, is very important, especially in precision agriculture, where the fertilizer rate should be adjusted to field variability in terms of nutrient content. Soil chemical analysis is time-consuming and expensive, and dense soil sampling is not always possible. In recent years, remote sensing methods have been used to assess the within-field variability of soil and crop nutritional status. The main aim of this study was to evaluate the relationship between UAV-derived spectral reflectance for winter rye in a long-term experiment for different fertilization with phosphorus and potassium. The study was conducted in 2022 in two field experiments in which winter rye was cultivated in monoculture and with crop rotation. The experiments were located in central Poland in Skierniewice. Statistical analyses were performed using univariate and multivariate methods, e.g., analysis of correlation, regression, and principal component analysis (PCA). The effect of phosphorus and potassium fertilization on the UAV-derived spectral reflectance of winter rye was weak, weaker in comparison to the effect of nitrogen fertilization. The effect of phosphorus and potassium fertilization on spectral reflectance was stronger in the experiment with monoculture than in the experiment with crop rotation. On the basis of correlation coefficients and PCA, negative relationships were proven between available soil potassium and spectral reflectance in the range of blue, green, and red bands and positive with red edge and near-infrared bands. The first principal component (PC1) was very strongly correlated with almost all spectral bands, either positively or negatively. The correlation of potassium and phosphorus content was very weak with PC1 in the experiment with crop rotation, while in the experiment with rye monoculture, the correlation was slightly stronger, indicating a stronger effect of nutrient deficiency in monoculture.
An Experimental Study on Antioxidant Enzyme Gene Expression in Trematomus newnesi (Boulenger, 1902) Experimentally Exposed to Perfluoro-Octanoic Acid
Authors: Pacchini Sara , Piva Elisabetta , Schumann Sophia , Irato Paola , Pellegrino Daniela , Santovito Gianfranco
Published: February 2023

Antarctica is the continent with the lowest local human impact; however, it is susceptible to pollution from external sources. Emerging pollutants such as perfluoroalkyl substances pose an increasing threat to this environment and therefore require more in-depth investigations to understand their environmental fate and biological impacts. The present study focuses on expression analysis at the transcriptional level of genes coding for four antioxidant enzymes (sod1, sod2, gpx1, and gpx4) in the liver and kidney of an Antarctic fish species, Trematomus newnesi (Boulenger, 1902). mRNA levels were also assessed in fish exposed to 1.5 μg/L of perfluoro-octanoic acid for 10 days. The kidney showed a higher level of expression than the liver in wildlife specimens. In the liver, the treatment induced an increase in gene expression for all the considered enzymes, whereas in the kidney, it induced a general decrease. The obtained results advance the scientific community’s understanding of how the potential future presence of anthropogenic contaminants in the Southern Ocean can affect the antioxidant system of Antarctic fishes. The presence of pollutants belonging to the perfluoroalkyl substances in the Southern Ocean needs to be continuously monitored in parallel with this type of research.
Potential Role of Superoxide Dismutase 3 (SOD3) in Resistance to Influenza A Virus Infection
Authors: Chen Feimin , Chen Liurong , Liang Jinlong , Chen Zhixuan , Zhang Chunyu , Zhang Zhengyin , Yang Jie
Published: February 2023

Influenza A virus infection induces the production of excessive reactive oxygen species (ROS). Overproduction of ROS can overwhelm the antioxidant defense system, leading to increasing intensive oxidative stress. However, antioxidant defense against oxidative damage induced by influenza A virus infection, and in particular the significance of the SOD3 response in the pathogenesis of influenza virus infection, has not been well characterized. Here, we investigated the potential role of SOD3 in resistance to influenza A virus infection. In this study, SOD3, as an important antioxidant enzyme, was shown to be highly elevated in A549 cells following influenza A virus infection. Furthermore, inhibition of SOD3 impacted viral replication and virulence. We found that SOD3 disrupts IAV replication by impairing the synthesis of vRNA, whereas it did not affect viral ribonucleoprotein nuclear export. In addition, overexpression of SOD3 greatly reduced the levels of ROS caused by influenza A virus infection, regulated the inflammatory response to virus infection by inhibiting the phosphorylation of p65 of the NF-κB signaling pathway, and inhibited virus-induced apoptosis to a certain extent. Taken together, these findings indicate that SOD3 is actively involved in influenza A virus replication. Pharmacological modulation or targeting of SOD3 may pave the way for a novel therapeutic approach to combating influenza A virus infection.
Phosphorylation of the Human DNA Glycosylase NEIL2 Is Affected by Oxidative Stress and Modulates Its Activity
Authors: Myrup Holst Camilla , Brøndum Andersen Nanna , Thinggaard Vibeke , Tilken Mine , Lautrup Sofie , Tesauro Cinzia , Stevnsner Tinna
Published: February 2023

The DNA glycosylase NEIL2 plays a central role in maintaining genome integrity, in particular during oxidative stress, by recognizing oxidized base lesions and initiating repair of these via the base excision repair (BER) pathway. Post-translational modifications are important molecular switches that regulate and coordinate the BER pathway, and thereby enable a rapid and fine-tuned response to DNA damage. Here, we report for the first time that human NEIL2 is regulated by phosphorylation. We demonstrate that NEIL2 is phosphorylated by the two kinases cyclin-dependent kinase 5 (CDK5) and protein kinase C (PKC) in vitro and in human SH-SY5Y neuroblastoma cells. The phosphorylation of NEIL2 by PKC causes a substantial reduction in NEIL2 repair activity, while CDK5 does not directly alter the enzymatic activity of NEIL2 in vitro, suggesting distinct modes of regulating NEIL2 function by the two kinases. Interestingly, we show a rapid dephosphorylation of NEIL2 in response to oxidative stress in SH-SY5Y cells. This points to phosphorylation as an important modulator of NEIL2 function in this cellular model, not least during oxidative stress.
High-Power Ultrasound in Gas Phase: Effects on the Bioactive Compounds Release from Red Bell Pepper during In Vitro Gastrointestinal Digestion
Authors: Reche Cristina , Rosselló Carmen , Eim Valeria , León Alberto Edel , Simal Susana
Published: February 2023

High-power ultrasound in gas-phase (28.8 kW/m3 for 120 min at 17.5 ± 0.3 °C) has been evaluated as a pre-treatment to enhance the release of antioxidants and phenolic compounds from red bell pepper during digestion. The moisture content decreased (34 ± 4%) while both the antioxidant activity (between 4 ± 1% and 21 ± 1%) and the phenolic compounds content (37 ± 4%) increased after the treatment. Moreover, microstructural changes were observed in the treated sample, with the appearance of breaks in the plant tissue, cell shrinkage, and an increased number of cells per area unit (28 ± 2%). Bioaccessibility was determined by in vitro gastrointestinal digestion. The total release of antioxidants and phenolic compounds after gastrointestinal digestion was 22–55% higher and 45 ± 7% higher, respectively, in the sonicated sample, with cell swelling and a 9.2 ± 0.1% higher number of cells per area unit. Therefore, the ultrasound treatment caused microstructural changes in the red bell pepper tissue, which could help to explain the higher release of bioactive compounds.
The Effect of Methyl Jasmonate-Doped Nano-Particles and Methyl Jasmonate on the Phenolics and Quality in Monastrell Grapes during the Ripening Period
Authors: Gil-Muñoz Rocío , Paladines-Quezada Diego Fernando , Giménez-Bañón María José , Moreno-Olivares Juan Daniel , Bleda-Sánchez Juan Antonio , Fernández-Fernández José Ignacio , Parra-Torrejón Belén , Ramírez-Rodríguez Gloria Belén , Delgado-López José Manuel
Published: February 2023

The effect produced by the application of methyl jasmonate (MeJA) in vineyards is clear, but this is a product that, despite its efficiency, is expensive, volatile and difficult to dissolve. Regarding increasing the MeJA use efficiency, new forms of application are proposed in this article, such as the use of calcium phosphate nanoparticles with two different morphologies: amorphous (ACP) and crystalline (Ap). In addition, few of the studies addressed so far have assessed MeJA’s effect during the ripening period of the grapes. As a result of this, in this article, we evaluated/studied for first time the effect of the different MeJA formats on the phenolic composition of the grape during the ripening period. The results showed small differences between the two morphologies of the nanoparticles, which promoted a significant a delay in the sugar accumulation and an increase in the different phenolic compounds compared to the control. Such improvements were not as significant as those induced by the conventional MeJA treatment. However, it is remarkable that when the nanoparticles were applied, we used a concentration 10 times lower than when it is used conventionally. Therefore, these findings revealed that both types of calcium phosphate nanoparticles are potential MeJA nanocarriers allowing for the increase in the quality of the grapes at the time of harvest in a more sustainable way, although future studies must be carried out in order to optimise the concentration with which these nanoparticles are doped.
Simple Route to Increase Electrical Conductivity and Optical Transmittance in Graphene/Silver Nanoparticles Hybrid Suspensions
Authors: Danilov Egor A. , Veretennikov Mikhail , Dronova Maria , Kalyakin Timofey , Stepashkin Andrey A. , Tcherdyntsev Victor V. , Samoilov Vladimir
Published: February 2023

Electrical and optical properties of graphene/silver nanoparticles hybrid suspensions intended for use in inkjet printing technologies were studied. Few-layered graphene particles were manufactured via a direct ultrasonic-assisted liquid-phase exfoliation route in water/surfactant system, whereas silver nanoparticles were synthetized using a polyol process. Hybrid suspensions for graphene/silver nanoparticles mixtures showed significant reduction in mean particle size while electrical conductivity remained almost intact even after thorough centrifugation. Structuring effects in mixed colloids were very pronounced as both electrical conductivity and optical transmission showed maxima at 65 wt.% graphene. Suspensions with conductivities above 300 μSm/cm, much higher than previously reported, were obtained, and resulted in the manufacturing of films with less than 10% optical absorption throughout the visible region. These samples did not demonstrate absorption peaks attributed to silver nanoparticles’ surface plasmon resonance, which is suitable for transparent electrode applications. Suspension properties at optimal composition (65 wt.% graphene) are very promising for printed electronics as well as transparent conductive coating applications. In the paper, we establish that the optimal suspension composition matches that of the film; therefore, more attention should be paid to carefully studying electrically conductive suspensions.
Physicochemical Properties and Sensory Attributes of Cold-Pressed Camelina Oils from the Polish Retail Market
Authors: Momot Monika , Stawicka Barbara , Szydłowska-Czerniak Aleksandra
Published: February 2023

Cold-pressed camelina oil (CPCO) is exceptional seed oil with a unique fatty acid profile promoting health and wellness. Therefore, this work focused on estimating and comparing the physicochemical properties and sensory quality of eight CPCO samples available on the Polish market. All analyzed oils were rich in α-linolenic acid (ALA = 29.91–36.27%) and contained low amounts of saturated fatty acids (SAFA = 10.61–12.20%). Oxidative stability of the studied CPCO samples, using the Rancimat test, ranged between 4.8 and 6.8 h, while peroxide (PV = 0.58–4.61 meq O2/kg) and anisidine (AnV = 0.15–1.60) values differed significantly. Moreover, the water and volatile matter contents (WVMC = 0.05–0.17%) and phosphorus level (P = 3.03–13.58 mg/kg) were monitored in commercial CPCO samples. Low concentrations of polycyclic aromatic hydrocarbon contaminants (Σ4PAHs = 0.72–7.22 μg/kg) were established in all oils. A quantitative descriptive analysis (QDA) was developed to characterize the sensory properties of eight CPCO samples. Six oil samples had high overall sensory quality (OSQ > 4.0), but OSQ < 3.5 was an unacceptance sensory quality for two of the oils. The developed lexicon might be used in the oil industry to monitor product quality, sensory profiling of new product development, and benchmark competitors’ samples.
Tree Species Classification Based on Self-Supervised Learning with Multisource Remote Sensing Images
Authors: Wang Xueliang , Yang Nan , Liu Enjun , Gu Wencheng , Zhang Jinglin , Zhao Shuo , Sun Guijiang , Wang Jian
Published: February 2023

In order to solve the problem of manual labeling in semi-supervised tree species classification, this paper proposes a pixel-level self-supervised learning model named M-SSL (multisource self-supervised learning), which takes the advantage of the information of plenty multisource remote sensing images and self-supervised learning methods. Based on hyperspectral images (HSI) and multispectral images (MSI), the features were extracted by combining generative learning methods with contrastive learning methods. Two kinds of multisource encoders named MAAE (multisource AAE encoder) and MVAE (multisource VAE encoder) were proposed, respectively, which set up pretext tasks to extract multisource features as data augmentation. Then the features were discriminated by the depth-wise cross attention module (DCAM) to enhance effective ones. At last, joint self-supervised methods output the tress species classification map to find the trade-off between providing negative samples and reducing the amount of computation. The M-SSL model can learn more representative features in downstream tasks. By employing the feature cross-fusion process, the low-dimensional information of the data is simultaneously learned in a unified network. Through the validation of three tree species datasets, the classification accuracy reached 78%. The proposed method can obtain high-quality features and is more suitable for label-less tree species classification.