bluuebunny/crossref_metadata_2025 huggingface dataset:
The Primate-Specific Presence of Interferon Regulatory Factor-5 Pseudogene 1
Authors: Marquis Avery , Hubing Vanessa , Ziemann Chanasei , Moriyama Etsuko N. , Zhang Luwen
Published: July 2024

Interferon regulatory factor 5 (IRF5) is a key transcription factor
regulating inflammatory cytokines and interferons, with its
dysregulation linked to autoimmune and inflammatory diseases.
Pseudogenes can exhibit gene regulatory functions. This study
investigates the human IRF5 pseudogene 1 (IRF5P1) and its potential role
in primate-specific innate immunity. We find that IRF5P1 is a chimeric
processed pseudogene containing sequences derived from multiple sources
and is specific to higher primates, such as apes and humans. Our
analyses suggest that IRF5P1 arose through an ancient retroviral
integration event, incorporating an IRF5-like sequence from a disparate
organism. Interestingly, IRF5P1 resides within the triple QxxK/R motif
containing (TRIQK) gene, and its antisense strand is predominantly
expressed as part of the TRIQK pre-mRNA. We propose that the antisense
IRF5P1 RNA may regulate IRF5 expression through complementary binding to
the IRF5 mRNA, with variants in the IRF5 gene potentially modulating
this interaction. The conservation of IRF5P1 in the primate lineage
suggests its positive effects on primate evolution and innate immunity.
This study highlights the importance of investigating pseudogenes and
their potential regulatory roles in shaping lineage-specific immune
adaptations.
Immunotoxicity of pembrolizumab in patients with metastatic non-small cell lung cancer: A single-centre study
Authors: Stojanovic Milos , Bursac Daliborka
Published: July 2024

Background: Immunotherapy represents a new form of treatment that stimulates the immune system to destroy cancer cells. Pembrolizumab is a humanized monoclonal antibody that binds to the PD-1 programmed cell death receptor and blocks its interaction with the PD-L1 and PD-L2 ligands. The aim of this study was to determine the efficacy and safety of the pembrolizumab drug, in the first line of treatment in patients with metastatic non-small cell lung cancer (NSCLC). Methods: The research was retrospective and was conducted at the Institute for Pulmonary Diseases of Vojvodina (IPDV). It included patients treated in the period from January 2018 to December 2019, in whom metastatic NSCLC was verified. Results: The study included a total of 20 patients - 10 men and 10 women. The average age was 61.75 years. The average length of therapy was 15 cycles (45 weeks), the minimum was 1, and the maximum was 33. Twelve patients (60%) had a lethal outcome. The median time to disease progression was 8.1 months and the overall survival was 14.6 months. Of the total number of patients, 13 (65%) had side effects to immunotherapy, and 7 (35%) did not experience any. Out of a total of 13 patients who had side effects, 9 had only one isolated, 4 had more associated side effects, of which 3 patients had 2 associated, and 1 patient had 3 associated side effects. Conclusion: Based on the results, immunotherapy certainly occupies an important place in the treatment of metastatic NSCLC. Namely, the lack of severe side effects linked to cytotoxic chemotherapy and the relative ease of treating immune related adverse events (irAEs) that occur with immunotherapy, good overall survival and later onset of disease progression opens the door to the possibility of a better quality of life for these patients and the prolongation of their lifespan.
Effects of sufentanil in combination with dexmedetomidine for patient-controlled intravenous analgesia after renal transplantation
Authors: Ma Jun , Yang Yawen , Sun Linhao , Wu Tingting
Published: July 2024

Background/Aim. Nowadays, the most convenient analgesic method is
patient-controlled intravenous injection of one or more adjuvant drugs. The
aim of our study was to evaluate the effects of sufentanil plus
dexmedetomidine for patient-controlled intravenous analgesia (PCIA) after
renal transplantation. Methods. Seventy-eight patients receiving
living-related renal transplantation under general anesthesia were selected.
Radioisotope scanning was performed, and the single glomerular filtration
rate of the unilateral kidney was ? 40 mL/min/1.73 m2. The control group
(CG) and observation group (OG) (39 patients in each group) were analgesic
with sufentanil and sufentanil plus dexmedetomidine, respectively. When the
Visual Analogue Scale (VAS) score exceeded 4 points, 0.05 mg/kg oxycodone
was intravenously injected for remedial analgesia. Plasma levels of
endothelin, urea nitrogen, and creatinine were measured by radioimmunoassay.
Heart rate (HR), mean arterial pressure, oxygen saturation, VAS score, and
sedation score were recorded before anesthesia and after surgery. Analgesic
remediation rate, number of effectively pressing the PCIA pump, and
incidence rate of adverse reactions within 48 hrs after surgery were
recorded. Results. HR of OG was significantly lower than that of CG 6 and 12
hrs after surgery (p < 0.05). VAS score of OG was lower than that of CG 6,
12, and 24 hrs after surgery (p < 0.05). OG had a lower postoperative
remedial rate, number of effectively pressing the PCIA pump, and incidence
rates of nausea and vomiting (p < 0.05) compared to CG. Endothelin, urea
nitrogen, and creatinine levels significantly decreased after surgery
compared with those before anesthesia (p < 0.05). The levels of OG were
lower than those of CG at each time point after surgery (p < 0.05).
Conclusion. Sufentanil plus dexmedetomidine can be safely and effectively
used for PCIA after renal transplantation, with superior outcomes to those
of sufentanil alone.
Medical Aid in Dying, Questions of Ethics and Fairness
Authors: P Hoffman David
Published: July 2024

Medical Aid in Dying (MAID) has received much exposure in a variety of forums. This has often been in the context of advocacy for or against making it legal in various states. It is currently legal in 11 U.S. jurisdictions.
Results of LRS (Limb Reconstruction System) in Management of Infected Non Unions of Femur
Authors: patel Jenil
Published: July 2024

Introduction: Infected non-union needs prolonged treatment and repeated surgeries which significantly impacts patient’s social, financial, physical and mental life. In relation to Ilizarov technique monolateral external fixator is less bulky, more comfortable and better tolerated by patient. In this study we aim to assess the union rates, infection control, alignment, complications and the functional outcome of infected femoral non-union managed with monolateral external fixator. Material and methods: This is a prospective interventional study carried out between June 2017 and June 2021 at tertiary care centre operated by a single surgeon. Patients diagnosed as infected non-union of femur clinically and radiologically and operated with monolateral external fixator were assessed. Functional and radiological assessment was done using ASAMI classification. Results: In our study 21 patients were operated which included 20 males (95.2%) and one female with mean follow up is 29.85 ± 11.42 months. The most common site of non-union is mid-shaft of the femur. The mean bone defect after debridement is 3.52 ± 2.23cm (1 -10cm). The mean time of bony union in our study is 180.65 days (range 95-740 days). The ASAMI classification of bone results is Excellent to good in 90% of patients. Conclusion: Our study suggested that the Limb reconstruction system can be successfully used in the management of infected non-union of femur as a stable fixation modality and achieve satisfactory outcome in terms of bony union and functional results. Pre-operatively planning of the LRS frame, radical debridement and maintaining stability of the LRS frame are key steps of the treatment.
Relationship between Gait Speed and Balance Among Older Adults Residing in Long Term Care Settings
Authors: N Girish
Published: July 2024

Introduction: Studies have documented that a decrease in gait speed is linked to an increased risk of falling among older adults residing in the community. However, there is a lack of research examining the correlation between gait speed and balance in older adults who reside in long-term care settings (LTCS). Objective: To determine the relationship between balance using a four-square step test (FSST) and gait speed using a 10-m walk test among older adults residing in LTCS in and around Udupi-Manipal. Methods: A cross-sectional study was conducted among older adults residing in six LTCS. The residents above 60 years, either gender, able to follow commands, with functional vision and duration of stay > 6 months were included, and those who were bed or wheelchair-bound, use assistive devices for mobility, any acute cardiovascular events in the past 3 months, any orthopaedic or neurological conditions that affect mobility, and with benign paroxysmal positional vertigo were excluded. The participants were asked to perform the FSST and gait speed test. The demographic characteristics were summarized using descriptive statistics. Linear regression analysis was carried out keeping balance as the outcome variable and gait speed as the independent variable. Results: A total of ninety-four residents were screened, and thirty-five (n=35) were included in the study. The mean age of participants was 74.94 ± 7.54 years, with an average duration of stay in LTCS being 5.37 years. The participant's average gait speed was 0.994 ± 0.325 m/s, and the average time taken to complete the balance test was 12.75 ± 4.41 sec. The regression analysis revealed that for every second decline in gait speed, the dynamic balance assessed by the FSST reduced by 0.036 seconds (r2 =0.443; p = 0.008; 95% CI: -.062, -.010). Conclusion: This study showed that with an increase in gait speed, the time taken to complete the balance test decreased. This suggests older adults have better balance abilities when they can walk at a faster speed.
Features of COVID-19 in the Elderly
Authors: Bharati Kaushik
Published: July 2024

The Coronavirus Disease 2019 (COVID-19) pandemic has caused havoc across the world over the past three years. The elderly people suffered the most during this unprecedented global public health calamity. The degree of suffering was magnified many fold in the elderly and frail individuals. They experienced atypical clinical disease presentation and developed more severe disease. Morbidity and mortality was also significantly higher in this group. Various risk factors have been identified that explain why older individuals are afflicted disproportionately and why they have an increased need for intensive care. Notably, severity of infections, vaccine-induced immune responses, and long-term outcomes of COVID-19 were also accentuated in the elderly, which have been explored in this review article.
Characterization and Antioxidant Activity Assay of Essential Oil Parts of Rosella (Hibiscus sabdariffa L.)
Authors: Helilusiatiningsih Nunuk , Syahara Muhammad Alwi , Irawati Titik
Published: July 2024

Rosella (Hibiscus sabdariffa L.) is known as a plant whose calyx contain high levels of antioxidant bioactive compounds and good inhibitory power against free radicals. However, other parts of the rosella plant have not yet been utilized for their antioxidant content and activity. The aim of this research is to compare the profiles of essential oils of parts of the rosella plant (seeds, leaves and flower petals) and their antioxidant activity. This research method begins with the process of extracting essential oils using the water-steam distillation method. Furthermore, the profile of the essential oil is known from the results of yield calculations and characterization using the GC-MS instrument. The antioxidant activity was tested using the DPPH method. The yield of essential oils obtained was 0.0107% for seeds, 0.0087% for leaves and 0.0136% for flower petals. GC-MS characterization shows that the most abundant chemical components contained in the essential oils of seeds, leaves, and flower petals are fatty acid compounds (2-propanoic acid, butanoic acid, hexanoic acid) and esters (neopentyl isobutyrate). The results of the antioxidant activity test showed the IC50 value for each essential oil, namely, seeds: 30.15 μg/ml, leaves: 171.27 μg/ml and flower petals: 126.58 μg/ml. The compound characteristics obtained showed the best results for rosella seed essential oil, this was supported by the fairly high antioxidant activity test results IC50 <50 μg/ml. Keywords: Antioxidant activity, Characterization, Essential oils, IC50, Yield.
E-Marketing in Snapchat and Its Impact on Convincing Customers
Authors:   Media Department, College of Arts, Salahaddin University, Muhsin Qadir Sara
Published: July 2024

ان تسويق الالكتروني أصبح أكثر الاستراتيجيات المستخدمة في وقتنا الحاضر و ذلك لما يتميز به من خصائص تجعله أداة مثمرة خاصة لعرض المنتجات عبر مواقع التواصل الاجتماعي ليتاثر المستخدمين بأقل تكاليف و سرعة إيصالها للجمهور. تكمن أهمية البحث في معرفة تاثير موقع سناب جات الذي يعتبر من اكثر المواقع استخداما خاصة في مجال التسويق لمنتجات مختلفة. تناول هذا البحث التسويق الالكتروني في سناب جات و أثره على اقناع الزبائن من خلال منهج مسحي. ويهدف البحث على معرفة تأثير التسويق الالكتروني على تحقيق ولاء الزبون و العملاء و القرارات الشرائية لهم. استخدم البحث المنهج المسحي لعرض و تحليل نتائج البحث, واستخدم الاستبانة لجمع البيانات من عينة البحث بشكل غير عشوائية القصدية, وتم جمع البيانات المطلوبة من عينة بلغت (100)مفردة من مستخدمي موقع سنابجات. وقد أظهرت نتائج البحث وجود تأثير إيجابي للتسويق عبر سنابجات. ومن أهم التوصيات تحديد إستراتيجية أفضل لجهود التسويق عبر وسائل التواصل الاجتماعي.
Prof. Dr. Mustafa Sabri Küçükaşcı nın Ardından
Authors: ÇETİN Engin
Published: July 2024

Mustafa Sabri Küçükaşcı, katıldığı bir televizyon programında
kendisine “ne mesaj vermek istersiniz?” diye sorulduğunda şu cevabı
vermişti:
…Âidiyet duygumuzu geliştirmemiz lazım. Çünkü âidiyeti
olmayan insanın mesûliyeti de olmaz…1
Bu yazıda Hoca’nın âidiyet ve mesûliyetleri ile ilmî mirası üzerinde
durulacaktır. Mustafa Sabri Küçükaşcı, kendisini her şeyden önce Allah’ın
kulu olarak görürdü. Dünya hayatını bu kulluk mesûliyeti ile yaşadı ve 30
Temmuz 2023’te rahmet-i Rahmân’a kavuştu2
. Hâfızlığı, talebeliği, hocalığı,
idareciliği, babalığı ve dostluğu; hülasa bütün sıfatları bu en temel âidiyete
göre şekillenmişti. Ardında, dedesi Hacıveyiszâde Mustafa Efendi’nin
“Müslüman olarak hepimiz Allah’ı sevmekle yükümlüyüz, ama Allah’ın
sevdiği kul olmaya çalışmamız lazım” ifadesinin nişânelerini taşıyan
hatıralar bıraktı. Tanıyan herkesin kendisine duyduğu sevginin ve dâima
hayırla yâd edilmesinin temelinde o Müslümanca hayatın bereketi
aranmalıdır.
Türkçe Kolay Dil e İlk Yaklaşımlar
Authors: GÖKTEPE Fayıka , DEMİRKIVIRAN Sine
Published: July 2024

Birçok iletişim aracı ve ürünü, erişilebilirlik konusunda bazı insanlar
için engeller oluşturur. İletişim engellerini aşmak için hali hazırda işaret dili
çevirisi, sesli betimleme, kabartma yazısı gibi çözümler sunulmaktadır.
Oysa bilişsel kısıtları veya dilsel yetersizlikleri olan insanlar da iletişim
engelleriyle karşılaşabilir. Bu bireyler için standart dili anlamak zor olabilir
veya ilgili metinler erişilebilir bir formatta sunulmayabilir. Bu çalışmada,
engelsiz iletişimi destekleyen ve ülkemizde de uygulanacak olan Kolay Dil
üzerinde durulacaktır. Kolay Dil, standart dili anlamakta güçlük çeken
bireyler için iletişim engellerini en aza indirgemek için tasarlanmış olup
iletişimin anlaşılırlığını ve erişilebilirliğini artırmayı hedeflemektedir. Bu
vesileyle Kolay Dil topluma ihtiyaç sahibi bu kitleyi dahil etmeyi amaçlayan
kapsayıcı bir yaklaşım benimser. Ülkemizde ise Kolay Dil çok yeni bir dilsel
fenomendir ve Türkçenin dilsel varyasyonu olacaktır. Türkçe Kolay Dil
çalışmalarına henüz başlanmış ve çalışmaların uygulama aşamasına
geçilebilmesi için kuramsal hazırlık aşaması devam etmektedir. . Bu nedenle
alana ilk katkılardan birini sağlayacak olan bu çalışmada Kolay Dil’in
engelsiz iletişim kapsamındaki önemine, dilde kolaylığın ne anlama
geldiğine vurgu yapılacaktır. Ayrıca Basit Dil konsepti ile Kolay Dil’in
farklarına değinilecektir. Son olarak da ülkemizde Kolay Dil’e kimlerine
ihtiyaç duyabileceğine değinilecek olup Türkçe Kolay Dil’e ilk yaklaşım
sergilenecektir.
A holisztikus, metabolikus-kardiorenális preventív szemlélet jelentősége a 2-es típusú diabétesz gondozásában
Authors: Winkler Gábor , Kis János Tibor , Vörös Péter , Arapovicsné Kiss Krisztina , Tóth A. , Kazinczy Rita , Schandl László
Published: July 2024

A 2-es típusú diabétesz vércukorcsökkentő kezelésének jelen gyakorlatában a korábbi glükocentrikus stratégiát felváltotta a célszerv-kímélő, a kardiorenális kockázatcsökkentést szem előtt tartó szemlélet. A közlemény áttekinti e károsodások – kiemelten a szívelégtelenség és a diabéteszes vesebetegség – kialakulásának mechanizmusait, valamint e terápiás paradigmát lehetővé tevő új, betegséglefolyást módosító gyógyszercsoportok, a nátrium-glükóz kotranszporter-2 gátlók és glükagonszerű peptid-1 receptoragonisták e szövődmények megelőzésében, mérséklésében szerepet játszó főbb hatásait. Rámutat, hogy noha továbbra is elengedhetetlen már a diabétesz legkorábbi szakaszától alkalmazott erélyes, az individuális célértéket biztosító glikémiás kontroll, az említett gyógyszercsoportok korai bevezetése tovább javíthatja a 2-es típusú cukorbetegség prognózisát.
MENINGKATKAN KEMAMPUAN MEMBACA HURUF HIJAIYAH MELALUI FLASHCARD PADA ANAK USIA 5-6 TAHUN TK Al FALAH
Authors: Khoirunnisa  , Islahudin Ahmad Noor , Noormawanti
Published: July 2024

Penelitian tindakan kelas (PTK) ini dilatar belakangi karena perlu adanya perhatian terhadap kemampuan membaca huruf hijaiyah masih kurang berkembang. Sehingga peneliti menggunakan media yang dapat meningkatkan kemampuan membaca huruf hijaiyah pada anak usia 5-6 Tahun di TK Al Falah kalidadi dengan menggunakan media flashcard. Salah satu tujuan penelitian ini adalah Meningkatkan Kemampuan Membaca Huruf Hijaiyah pada anak usia 5-6 Tahun menggunakan penerapan media Flashcard. Metode penelitian yang digunakan adalah penelitian tindakan kelas yang terdiri dari 2 siklus. Setiap siklus terdiri dari empat tahap pokok yang saling terikat dan berkesinambungan Yaitu perencanaan (planning), pelaksanaan (acting), pengamatan (Observasing), dan refleksi (reflecting). Pada pra siklus ini terdapat 7 anak (28%) yang tergolong kedalam kategori belum berkembang, 10 orang anak (40% ) tergolong kategori mulai berkembang, 6 orang anak (24%) tergolong dalam kategori sesuai harapan dan ada 2 anak yang tergolong dalam kategori berkembang sangat baik. Hasil penelitian pada siklus I mengalami peningkatan dibandingkan dengan pra siklus, siswa yang tuntas dari 2 menjadi 5 jika dihitung nilai rata-rata yang diperoleh pada siklus I adalah 76,4 namun skor yang diperoleh masih dibawah skor minimum. Hasil observasi siswa mendapatkan hasil prosentase 68,33%. Pada siklus I terdapat beberapa kendala, salah satunya yaitu guru yang dirasa kurang maksimal dalam pembelajaran berlangsung. Siklus II merupakan perbaikan dari siklus I, guru saling berdiskusi bersama untuk mengatasi masalah yang dialami pada siklus I agar mendapatkan hasil yang dicapai. Hal tersebut terbukti pada siklus II yang mengalami peningkatan hasil belajar siswa, hasil rata-rata yang didapatkan 87,04 dengan prosentase 88,33%.
Kata kunci: Flashcard; Kelompok B; Membaca huruf hijaiyah.
Japón y el nuevo orden internacional: la inevitable transformación de su diplomacia
Authors: Vidal Lluc ,   Director del Grado de Relaciones Internacionales, Universitat Oberta de Catalunya (UOC)
Published: July 2024

La evolución de la política exterior japonesa desde la doctrina Yoshida hasta las doctrinas Abe y Kishida refleja un proceso de normalización que busca adaptar la diplomacia del país a las nuevas realidades internacionales, dejando atrás el pacifismo adoptado tras la Segunda Guerra Mundial, pero sin incurrir en el militarismo. Las reformas impulsadas por los gabinetes de Abe y Kishida han fortalecido las capacidades defensivas de Japón y han promovido su participación más activa en la seguridad global, especialmente en la región del Indopacífico. Esta normalización de Japón responde al pragmatismo de sus élites políticas, que buscan asegurar la autonomía y la influencia del país en un orden internacional liberal en crisis.
Between two states: Cultural relation in frontier area Indonesia-Philippines
Authors: Kamajaya Alkatuuk Uus Martinus , Pristiwanto Pristiwanto , Djakaria Salmin , Anwar Hasanuddin , Ichsan Azis Muhammad Nur , Kenda N. , Sandiah Nasrun
Published: July 2024

This article aims to describe and analyze pattern of management learning communities in frontier area Indoensia-Philippines. The relationship between Indonesia-Phlippines in frontier area represents a unique intersection culture and dynamic interplay onf interaction. The people in frontier area were relating by the historical events in the past. This article using historical methods; heuristic, critics/verification, interpretation and historiography were to emphasize the utilization of primary sources. The primary source collected from the oral tradition between Indonesia-Philippines people in frontier area. This article employs a social scientific approach to elucidate the cultural relationships within border communities. Cultural relationships are indicative of an extensive process that exerts influence on communal living practices in the management of their existence as a unique identity. This study provides a comprehensive analysis of the cultural relations in the frontier area between Indonesia and the Philippines. The findings offer insights into the intricate interplay of factors shaping cultural dynamics in border regions, contributing to a deeper understanding of cross-border interactions and the construction of cultural identities.
The Effect of Village Fund on Inequality and Inclusive Growth in Indonesia: A District Level Case Study
Authors: Putra Wahyu Pratama , Prasetyia Ferry
Published: July 2024

Objective –This study tries to find the relationship between Village Fund expenditures and the inequality and growth inclusiveness using data from 434 districts for the time span of seven years from 2015 to 2021.Design/Methodology –This study uses quantitative research. The research data comprised the data of Village Fund, Gini Ratio, and Inclusive Growth Index from the Ministry of Finance, Central Bureau of Statistics, and the Ministry of National Development Planning. To investigate the relationship between variables, a dynamic panel data with Generalized Method of Moment (GMM) approach is applied.Results –This study revealed the relationship between Village Fund and Inequality and Inclusive Growth. We found that there is no strong relationship between the Village Fund, the first lag of the Village Fund, the second lag of Village Fund and Inequality among specifications. Similar relationships are also shown by the Village Fund, the first lag of Village Fund, the second lag of the Village Fund, and the Inclusive Growth among specifications. In other words, the implementation of Village Fund could not eradicate the inequality problem and could not support inclusion of economic growth in the village level.Research Limitations/Implications –The result of this study potentially has a major implication in terms of program delivery effectiveness and the factors that influence the program effectiveness.  Furthermore, in this particular research, the major problems with village fund allocation are the equity issue of the allocation scheme and the clarity of the village service responsibilities.Novelty/Originality –This study uses a different approach to the panel data, which is a dynamic panel data with GMM approach. This study also uses a more specific scope of the data which is a district (kabupaten/kota) level in Indonesia.
Beyond Expectations: Corporate Governance's Insufficiency in Fraud Prevention
Authors: Nuraini A Nuraini A , Ariani Nita Erika , Lautania Maya Febrianty
Published: July 2024

Objective –The specific objectives to be achieved in this research are to (1) test the Beneish model (1999) as a predictor of reliable manipulation or indicator to reveal signals or symptoms of financial reporting fraud. (2) Test whether corporate governance effectiveness reduces financial statement fraud.Design/Methodology –The research analyzed publicly listed non-financial firms listed in Indonesia's stock exchange (IDX) from 2017 to 2022. Simple random sampling was used to select 86 companies per year, resulting in 617 year-firm observations. Data analysis was carried out by logistic regression multiple with panel data. The test was carried out by adopting the Beneish benchmark index (Z-score) model which is effective for predicting indications of fraudulent financial statements. Results –The test results show that there is 99.8% of incidents indicated financial statement fraud and the other 0.2% did not indicate financial statement fraud. Corporate governance mechanisms consisting of institutional ownership, audit committees, and audit quality does not mitigate fraud. It is anticipated that the research's contribution will serve as a practical guide and reference for the examination of indicators of fraud in corporate finances. The findings of this study are expected to provide valuable insights for policymakers and regulators seeking to improve corporate governance practices.Research limitations/implications –This research does not incorporate the competency and capability specifications of governance structures such as the board of commissioners, audit committees, and external auditors. Future investigations are anticipated to delve more profoundly into the internal and external corporate governance capabilities and specifications.Novelty/Originality –This study reveals that, on the whole, a significant proportion of companies are implicated in fraudulent activities, while corporate governance mechanisms are deemed inadequate in overseeing management activities conducive to fraud. The outcomes of this research challenge the prevailing paradigm of corporate governance as an effective deterrent against fraudulent behavior.
ВІЗУАЛІЗАЦІЯ НАВЧАЛЬНОЇ ІНФОРМАЦІЇ ПІД ЧАС ВИКЛАДАННЯ ДИСЦИПЛІНИ “ФІЗІОЛОГІЯ ЛЮДИНИ” ДЛЯ МАЙБУТНІХ ФАХІВЦІВ ФІЗКУЛЬТУРНО-СПОРТИВНОГО ПРОФІЛЮ
Authors: Квасниця Ірина , Квасниця Олег , Дмитришин Нікіта
Published: July 2024

У статті розглянуто питання візуалізації навчальної інформації при вивченні дисципліни “Фізіологія людини” у професійній підготовці майбутніх фахівців фізичної культури і спорту. Візуалізацію визначено як спосіб унаочненого висвітлення змісту навчального матеріалу за допомогою презентацій, тривимірних компʼютерних моделей органів та систем організму людини, діаграм, сторітелінгу, ментальних карт, віртуальних лабораторій, що сприяє ефективному оволодінню здобувачами освіти системою компетенцій. Обґрунтовано, що візуалізація змісту навчального матеріалу дає змогу виконати низку педагогічних завдань, а саме: формує у здобувачів освіти загальні й професійні компетентності; сприяє інтенсифікації навчання; активізує навчальну й пізнавальну діяльність; розвиває критичне та креативне мислення.
НЕПЕРЕРВНА ДИЗАЙН-ОСВІТА В СІНГАПУРІ
Authors: Бровченко Анатолій
Published: July 2024

У статті висвітлюються особливості неперервної дизайн-освіти міста-держави Сінгапур. В ній подано структуру шкільної освіти країни та принцип розподілу учнів за потоками в середній школі. Розкриті завдання, які ставляться при вивчені предмету дизайн і технології, в молодшій і середній школі. Висвітлено питання про запровадження з 2024 р. змішаних класів на основі повного групування за предметами на зміну потокового розподілу учнів в середній школі та місце предмету дизайн і технології в цьому процесі. Висвітлено можливості подальшого навчання дизайну здобувачів освіти після закінчення середньої школи аж до докторантури та післядипломної освіти.
FOREIGN LANGUAGE ACQUISITION THROUGH ARTIFICIAL INTELLIGENCE TECHNOLOGY
Authors: Tynnyi Vadym , Schukina Emma , Belyakova Olga
Published: July 2024

У статті автори аналізують різні визначення, сутність та особливості штучного інтелекту (ШІ), його значення для підвищення ефективності вивчення англійської мови, удосконалення комунікативної та професійної компетентності студентів. Особливістю штучного інтелекту є те, що це комп’ютерне моделювання людського інтелекту розроблене для функціонування подібного людині. Мета створення штучного інтелекту полягає у тому, щоб полегшити освіту у викладанні та вивченні іноземної мови. Пропонована розвідка розкриває роль штучного інтелекту у викладанні іноземних мов і досліджує технології, що підтримуються штучним інтелектом у цьому навчальному процесі. Штучний інтелект пропонує ефективну навчальну атмосферу для вивчення іноземної мови, зокрема курсу англійської. Іншою відмінною перевагою ШІ є його здатність створювати особистісно орієнтовану атмосферу, в якій студенти використовують свої знання та досвід для одночасного вдосконалення іншомовних навичок, враховуючи власний поточний рівень володіння іноземною мовою, бажання та потреби. Технології ШІ створюють технічне середовище для розвитку іншомовних навичок. Можливості сучасного програмного забезпечення на основі ШІ дають змогу організувати застосування цих технологій відповідно до умов вивчення англійської мови. Широкий спектр засобів навчання полегшує оволодіння студентами англійською мовою. Велика різноманітність іншомовних додатків із підтримкою штучного інтелекту, включаючи мобільне та програмне забезпечення, пропонує студентам багато опцій. Зазначені своєрідні технології характеризуються людською поведінкою та мисленням завдяки моделюванню інтелекту та прийняттю обґрунтованих рішень, ідентичних людським. Прикладами технологічних розробок на основі ШІ є онлайн-платформи English Able, Text to speech, Google Translate, Orai, та інші.
ПЕДАГОГІЧНІ УМОВИ ПРОФЕСІЙНОЇ ПІДГОТОВКИ МАЙБУТНІХ УЧИТЕЛІВ ДО ПАРТНЕРСЬКИХ ВЗАЄМИН ІЗ БАТЬКАМИ УЧНІВ
Authors: Щербакова Надія
Published: July 2024

У статті здійснено аналіз проблеми професійної підготовки майбутніх педагогів до встановлення партнерських взаємин із батьками учнів. Запропоновано здійснювати вивчення змістового модуля “Організація партнерських взаємин вчителя з батьками учнів” у межах обов’язкової навчальної дисципліни педагогіка шляхом створення визначених педагогічних умов (стимулювання ціннісно-мотиваційного та відповідального ставлення до взаємин із батьками на засадах педагогіки партнерства, використання інноваційних форм і методів навчання (перевернуте навчання, професійні ігри та ігрові ситуації). Доведено, що такий підхід забезпечує ознайомлення майбутніх учителів з особливостями налагодження партнерських взаємин із батьками учнів, а також практичну підготовку студентів до впровадження здобутого досвіду в майбутній професійній діяльності.
The Internet as A Democratic Hellscape
Authors: Crawford Claire
Published: July 2024

This paper applies John Locke's political philosophy to dissect the 2018 Facebook-Cambridge Analytica data scandal, revealing how social media's democratic promise can turn into a profit-driven, unjust digital governance. Locke's Two Treatises of Government serves as a theoretical lens to explore how social media sites, initially perceived as democratic spaces, can devolve into unjust and illegitimate digital governments. The contemporary moment inextrixibly intertwines the Internet and capital, resulting in profit as the driving force behind social media sites. This driving force thus biases digital giants, resulting in a dissonance between the percieved democratizing potential of the Internet and the reality of how these sites operate. By scrutinizing the breach of natural rights and the erosion of user trust, the paper argues that Facebook's actions create what Locke would define as a state of war between the platform and its users. The essay urges digital citizens to be aware of these dynamics so that there can be collective resistance against illegitimate digital governments. With this framework, digital citizens are given the tools to create just communities in the evolving digital lanscape.
PERFIL DOS CASOS SUSPEITOS DE INTOXICAÇÃO EXÓGENA EM CÃES E GATOS ATENDIDOS NO HVU UFPI DE TERESINA-PI NO PERÍODO DE 2017 A 2021)
Authors: Leal Sayonara Maria Santos , Santana José Luís de Sousa , Araújo Roniuza Reneuda de , Ferreira Siluana Benvindo , Tenório Taciana Galba da Silva , Rodrigues Marcelo Campos , Feitosa Lauro César Soares
Published: July 2024

Os casos suspeitos de intoxicações exógenas são frequentes na clínica de cães e gatos. O presente trabalho objetivou realizar um estudo retrospectivo dos casos suspeitos de intoxicação em cães e gatos atendidos no Hospital Veterinário Universitário da UFPI, localizado em Teresina PI, durante o período de 2017 a 2021. Os casos foram classificados por agente tóxico suspeito, espécie, idade e ano de ocorrência. No total foram registrados 324 casos, sendo 58 em 2017, 88 em 2018, 94 em 2019, 50 em 2020 e 34 em 2021. A maioria dos casos ocorreu em 2019 (29,01%) tendo como causa principal a intoxicação medicamentosa (16,04%), seguida da intoxicação por agrotóxicos (10,80%). A maior prevalência foi em animais com idade inferior a cinco anos (87,03%); machos (56,79%); cães (68,20%). Foram observados: elevado número de casos sem agente tóxico identificado (28,08%) e de fichas de atendimento não preenchidas (8,33%) pelos médicos veterinários em atendimento. A prevenção, a educação continuada dos tutores e a capacitação dos médicos veterinários são destacadas como essenciais para a redução dos casos de intoxicações exógenas em cães e gatos.
Impact of Smoking on Dental Caries and Gingival Health Among Dental Student in The College of Dentistry / Tikrit University/ Iraq
Authors: T. Hamid Hind
Published: July 2024

Smoking has a negative impact on overall health including oral health causing dental caries, gingivitis, periodontitis, calculus and other effects.
Aim of study: This study was conducted to assess correlation between cigarette smoking and oral health condition among dental student in college of dentistry/ Tikrit university.
Material and Methods: Students (male only) from Tikrit university were selected on a random basis, after consent form has been obtained from participants. They were divided into two groups, smoking and nonsmoking groups. Dental caries experience was diagnosed and scored according to the index of DMFs (WHO).
Results: In the present study dental caries and   mean value of (PI, GI, Cal) index were higher among smoking students than non-smoking group. 
Conclusion: According to our findings in the current study, smoking had an effect on dental caries and gingivitis, as smoking dental students had higher levels of dental caries and gingivitis than nonsmokers.
The Effects of Air Abrasive Polishing on the Release of Iron Ions from Various Orthodontic Arch Wires (Stainless Steel and Nickel Titanium)
Authors: Ali Mohammed Mohanad , Issa Saleem Alan
Published: July 2024

Orthodontic treatment with has been increasingly demanded. However, when using fixed appliances for orthodontic treatment, oral hygiene is compromised, and there is a higher chance of developing dental stains, plaque-related diseases, and corrosion-related problems. Air abrasive polishing had a superior effect over the conventional method in removing dental deposits, however, its effect on corrosion process was not investigated thoroughly in details. This study designed to assess the effects of air polishing onion release and surface micromorphology of stainless steel and Nickel titanium arch wires. A total of 288 ( stainless-steel , coated stainless steel , Nickel titanium and coated Nickel titanium  rectangular arch wires )  of one brand ( The Ultimate Wire) ™ From IOS (International Orthodontic Services, Stafford, USA), (0.016 * 0.022 ) were subjected to varying air abrasion polishing periods (5, 10, and 20 seconds), after which they were immersed in artificial saliva with a pH of 6.75 and incubated at 37°C for 28 days. Ion release was measured using an atomic absorption spectrophotometer at 7 days, 14 days, and 28 days. The cumulative effect was then calculated. After polishing the chosen sample, corrosion and surface changes were evaluated using a scanning electron microscope (SEM). The significant difference between the analysed groups was found using an analysis of variance (ANOVA) and the LSD test, with a significance level of p 0.05. The results revealed that all types of arch wire showed a significant amount of release in the tested ions and the amounts of nickel and iron ions released was higher than chromium ion. Additionally, the longer the polishing time the higher the number of ions release that’s yields the level of significance, air abrasion polishing increased surface roughness and surface pits and crevices.It may be concluded that the air polishing method enhanced the amount of ion release to a subtoxic level and could be employed in adult patients with a lengthy time between visits.This study was performed to:1. Evaluate the effect of calcium carbonate airborne particles abrasion with different polishing times 5, 10 and 20 seconds on (Fe) ions release from orthodontic arch wires. 2. Assess the surface micromorphology of orthodontic arch wires after air polishing procedure.
Additive Manufacturing Technologies in Dentistry (A Review)
Authors: Azat Abdulkareem Maryam , M.W. Al-Shamma Abdulla
Published: July 2024

Background: Significant advancements have been observed in the additive manufacturing (AM) technology industry in recent decades. Due to the inherent variations among each AM manufacturing technique, new areas of investigation continually arise and require consideration. Additionally, the novel applications of additive manufacturing present new difficulties and possibilities for targeted focus. The aim of this manuscript is to conduct a comprehensive literature review that describes the various processing methods, precision levels, types of materials utilized, and potential applications of 3D printing technology in the field of dentistry. Data: An online search was conducted on databases including Research Gate, Google Scholar, and PubMed to identify potential applications of AM technologies in the dental industry. The most relevant studies on the subject were selected, including English-language articles published between 2006 and 2022.
Conclusion: It is feasible to incorporate a variety of AM techniques in dentistry, which has led to improved workflow and acceptable clinical results. Moreover, the different technologies of 3D printing have a broad array of potential applications, enabling the development of novel and optimized techniques to produce dental products.
An In-Vitro Study of the Cytotoxicity of Chitosan Nanoparticles-Containing Orthodontic Primer
Authors: R. Mohammed Rawnaq , A. Rafeeq Reem
Published: July 2024

Background: Demineralization is an anticipated side effect of fixed orthodontic treatment. Incorporating antimicrobial compounds into orthodontic adhesive material may be an effective method for averting white spots. The objective of this study was to evaluate the cytotoxicity of an orthodontic primer modified with varying quantities of chitosan nanoparticles. Materials and methods: 0%, 1%, 5%, and 10% concentrations of Chitosan nanoparticles have been combined with Transbond TM XT primer. Three discs of eight millimeters in diameter and two millimeters in thickness were constructed for each group, for a total of twelve discs. Results: included the application of scanning electron microscopy (SEM) and X-ray diffraction (XRD) to confirm the Nano powder's properties. The data was statistically examined using one-way analysis of variance (ANOVA), and the results indicated statistically non-significant differences between groups (p˃0.05). 
In conclusion, the addition of chitosan nanoparticles to the orthodontic adhesive system's primer exhibited an acceptable level of cytotoxicity and was within the appropriate ISO limits (70% cell viability).
PENGARUH PENGUNGKAPAN LAPORAN KEBERLANJUTAN (SUSTAINABILITY REPORT) TERHADAP KINERJA KEUANGAN PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2019 - 2021
Authors: Armalina Ika Puji Astuti
Published: July 2024

Penelitian ini bertujuan untuk menganalisis Pengaruh Pengungkapan Laporan Keberlanjutan (Sustainability Report) Terhadap Kinerja Keuangan Perusahaan Yang Terdaftar di Bursa Efek Indonesia Tahun 2019 – 2021. Jenis penelitian ini ialah penelitian kuantitatif. Sumber data penelitian ini menggunakan data sekunder yang diperoleh dari laporan keuangan perusahaan yang dipublikasikan di Bursa Efek Indonesia (BEI) dan juga menggunakan laporan keberlanjutan (Sustainability Report) yang diperoleh dari website resmi perusahaan maupun di Bursa Efek Indonesia (BEI). Data dianalisis menggunakan program SPSS 26 (Statistical Product and Service Solutions). Uji Hipotesis berdasarkan uji F menunjukkan tidak ada pengaruh yang signifikan secara simultan antara variabel independen terhadap variabel dependen. Sedangkan untuk Uji t dimensi ekonomi (X1), dimensi lingkungan (X2) dan dimensi sosial (X3) disimpulkan ketiga dimensi tersebut masing-masing tidak berpengaruh terhadap kinerja keuangan (Y).
AKUNTABILITAS PENGELOLAAN KEUANGAN ALOKASI DANA DESA DALAM MENINGKATKAN KESEJAHTERAAN MASYARAKAT KABUPATEN MANGGARAI BARAT TAHUN 2022 (Studi di Desa Compang Kules Kecamatan Kuwus Barat Kabupaten Manggarai Barat)
Authors: Maria Priyanti Ganggur  , Miftahol Horri
Published: July 2024

Akuntabilitas merupakan suatu pertangungjawaban pemerintah untuk melaporkan dan menyajikan kegiatan-kegiatan yang telah dilaksanakan kepada masyarakat. Pertanggungjawaban tersebut dilakukan agar pemerintah dapat transparan dengan komitmen yang telah terbentuk dalam pelaksanaannya. Pemerintah desa Compang Kules, kecamatan Kuwus Barat, kabupaten Manggarai Barat adalah pemerintah desa yang mendukung adanya Good Governance khususnya akuntabilitas dan Pengelolaan. Penelitian ini bertujuan untuk menilai akuntabilitas Pengelolaan Alokasi Dana Desa (ADD)Di Desa Compang Kules Kecamatan Kuwus Barat,Kabupaten Manggarai Barat. Penelitian ini menggunakan metode kualitatif dengan pendekatan analisis deskriptif. bahwa penelitian deskriptif kualitatif adalah menguraikan pendapat responden apa adanya sesuai dengan pertanyaan penelitian, kemudian dianalisis dengan kata-kata yang melatarbelakangi responden berperilaku seperti itu, direduksi, ditriangulasi, disimpulkan, dan diverifikasi.. Hasil penelitian ini menunjukan pengelolaan keuangan Alokasi Dana Desa yang diterapkan oleh pemerintah desa Compang Kules sudah sesuai dengan perundang-undangan maupun ketentuan-ketentuan yang berlaku. Pengelolaan yang dilakukan oleh pemerintah desa Compang Kules menggunakan media informasi, terdapat informasi yang disebar tiap-tiap dusun melalui ketua RT dan Ketua Dusun, selain itu juga terdapat papan informasi yang ditempatkan di Kantor Desa. Meskipun pengelolaan Dana Desa yang dilakukan oleh pemerintah desa sangat baik, tetapi pemahaman masyarakat mengenai kebijakan Alokasi Dana Desa masih rendah.
PENGARUH GREEN ACCOUNTING TERHADAP KINERJA KEUANGAN DENGAN CORPORATE SOCIAL RESPONSIBILITY (CSR) SEBAGAI MEDIASI
Authors: Noviolita Lingga Asti  , Yoosita Aulia
Published: July 2024

Penelitian ini dilakukan untuk mengetahui pengaruh green accounting terhadap kinerja keuangan dengan corporate social responsibility (CSR) sebagai variabel mediasi. Penelitian ini menganalisis perusahaan manufaktur sektor energi yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2019-2021. Jenis penelitian yang digunakan adalah penelitian kuantitatif. Data yang digunakan adalah data sekunder dari laporan tahunan dan laporan keberlanjutan perusahaan. Sampel dalam penelitian ini sebanyak 12 perusahaan manufaktur sektor energi yang terdaftar di Bursa Efek Indonesia (BEI) secara berturut-turut tahun 2019-2021. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik purposive sampling. Teknik analisis data yang digunakan adalah path analysis menggunakan program aplikasi statistik SPSS. Hasil penelitian menunjukkan bahwa (1) Green Accounting berpengaruh terhadap Kinerja Keuangan; (2) Green Accounting berpengaruh terhadap Corporate Social Responsibility (CSR); (3) Corporate Social Responsibility (CSR) tidak berpengaruh terhadap Kinerja Keuangan; (4) Corporate Social Responsibility (CSR) tidak mampu memediasi pengaruh antara Green Accounting terhadap Kinerja Keuangan.
PENGARUH PROFITABILITAS, LEVERAGE, DAN KEPEMILIKAN MANAJERIAL TERHADAP AGRESIVITAS PAJAK PADA PERUSAHAAN INDUSTRI SEKTOR PERTAMBANGAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2019-2021
Authors: Suci Maulina Susanto
Published: July 2024

Penelitian ini bertujuan untuk menguji pengaruh profitabilitas, leverage, dan kepemilikan manajerial terhadap agresivitas pajak. Populasi yang digunakan yaitu perusahaan industri sektor pertambangan yang terdaftar di Bursa Efek Indonesia 2019- 2021. Penentuan sampel yang digunakan dalam penelitian ini menggunakan metode purposive sampling. Metode analisis data menggunakan regresi linier berganda, dan untuk pengolahan data menggunakan SPSS versi 26. Penelitian ini memperoleh hasil bahwa profitabilitas berpengaruh negatif secara signifikan terhadap agresivitas pajak. Sedangkan leverage dan kepemilikan manajerial tidak berpengaruh secara signifikan terdahap agresivitas pajak.  Dan berdasarkan uji simultan menunjukkan profitabilitas, leverage, dan kepemilikan manajerial berpengaruh secara simultan terhadap agresivitas pajak.
PENGARUH PRESSURE, OPPORTUNITY, DAN RATIONALIZATION TERHADAP PERILAKU KECURANGAN AKADEMIK YANG DILAKUKAN OLEH MAHASISWA AKUNTANSI PADA PERKULIAHAN ONLINE (Studi Empiris Pada Mahasiswa Program Studi Akuntansi Perguruan Tinggi Swasta Kota Surabaya)
Authors: Rosalind Cahya Dianti  , Alberta Esti Handayani
Published: July 2024

Penelitian ini bertujuan untuk menguji Pengaruh Pressure, Opportunity, dan Rationalization Terhadap Perilaku Kecurangan Akademik yang dilakukan oleh mahasiswa Akuntansi Perguruan Tinggi Swasta Kota Surabaya pada perkuliahan online. Data yang  digunakan pada penelitian ini adalah data primer, teknik pengumpulan data menggunakkan kuesioner dengan metode purposive sampling. Hasil dari penelitian ini menyatakan bahwa Opportunity dan Rationalization berpengaruh secara signifikan terhadap Perilaku Kecurangan Akademik. Sedangkan Pressure tidak berpengaruh secara signifikan terhadap Perilaku Kecurangan Akademik pada perkuliahan online.
Association of LDLR Gene Polymorphism with the Risk of Cardiovascular Disease in End-Stage Kidney Disease Patients on Maintenance Hemodialysis
Authors: Osman Enas Ahmed , Shawky Hanan , Abbas Rania Mohammed , Metwaly Amna Ahmed , Ibrahim Anas Hassan , Khanany Farida Mohamed
Published: July 2024

Background

The low-density lipoprotein receptor (LDLR) is essential for regulating intracellular cholesterol levels. Mutations in the LDLR gene can cause a increase in LDL cholesterol levels in the blood, elevating the vulnerability to cardiovascular disease (CVD). This study evaluated the correlation between the LDLR rs688 polymorphism and CVD risk in chronic kidney disease (CKD).

Materials and Methods

Polymorphism in this case-control study was genotyped using the TaqMan real-time polymerase chain reaction in a cohort of 100 CKD patients (Group I) and 100 healthy controls (Group II). We examined the LDLR rs688 allele and genotype distribution in 50 CKD cases with CVD and 50 cases without CVD.

Results

There was a significantly greater frequency of CT variant of LDL SNP rs688 in Group I than in Group II (p = 0.006). CT and TT genotypes were significantly higher in CKD patients with CVD, with odds ratios (ORs) (95% CI) of 4.3 (1.6–11.8, p = 0.004) and 7.6 (2.3–24.8, p = 0.001), respectively.

Conclusion

SNP rs688 C>T detection in the LDLR gene showed that CT and TT genotypes are associated with elevated CVD risk in CKD.