bluuebunny/crossref_metadata_2025 huggingface dataset:
A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode
Authors: Zhao Dongping , Liu Liqin , Liu Xinlin , Zhang Jinlei , Yin Yuqing , Luan Linli , Jiang Dingwen , Yang Xiong , Li Lei , Xiong Hualong , Xing Dongming , Zheng Qingbing , Xia Ningshao , Tao Yuyong , Li Shaowei , Huang Haiming
Published: September 2022

The major challenge to controlling the COVID pandemic is the rapid mutation rate of the SARS-CoV-2 virus, leading to the escape of the protection of vaccines and most of the neutralizing antibodies to date. Thus, it is essential to develop neutralizing antibodies with broad-spectrum activity targeting multiple SARS-CoV-2 variants. Here, we report a synthetic nanobody (named C5G2) obtained by phage display and subsequent antibody engineering. C5G2 has a single-digit nanomolar binding affinity to the RBD domain and inhibits its binding to ACE2 with an IC50 of 3.7 nM. Pseudovirus assays indicated that monovalent C5G2 could protect the cells from infection with SARS-CoV-2 wild-type virus and most of the viruses of concern, i.e., Alpha, Beta, Gamma and Omicron variants. Strikingly, C5G2 has the highest potency against Omicron BA.1 among all the variants, with an IC50 of 4.9 ng/mL. The cryo-EM structure of C5G2 in complex with the spike trimer showed that C5G2 binds to RBD mainly through its CDR3 at a conserved region that does not overlap with the ACE2 binding surface. Additionally, C5G2 binds simultaneously to the neighboring NTD domain of the spike trimer through the same CDR3 loop, which may further increase its potency against viral infection. Third, the steric hindrance caused by FR2 of C5G2 could inhibit the binding of ACE2 to RBD as well. Thus, this triple-function nanobody may serve as an effective drug for prophylaxis and therapy against Omicron as well as future variants.
Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents
Authors: Kumar Harsh , Kumar Davinder , Kumar Pradeep , Thareja Suresh , Marwaha Minakshi Gupta , Navik Umashanker , Marwaha Rakesh Kumar
Published: September 2022

Background

A novel series of thiazolidine-2,4-dione molecules was derived and their chemical structures were established using physiochemical parameters and spectral techniques (1H-NMR, IR, MS etc.). The synthesized molecule were then evaluated for their antioxidant, anticancer and antimicrobial potential.

Results and discussion

Serial tube dilution method was employed to evaluate the antimicrobial potential against selected fungal and bacterial strains by taking fluconazole and cefadroxil as reference antifungal and antibacterial drugs respectively. 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity was used to assess the antioxidant potential of the synthesized analogues. Further, the anticancer potential of the selected molecules was assessed against DU-145 cancer cell lines using MTT assay. The drug-likeness was also evaluated by studying in-silico ADME parameters of the synthesized analogues.

Conclusion

In antioxidant evaluation studies, the analogue H5 with IC50 = 14.85 μg/mL was found to be the most active molecule. The antimicrobial evaluation outcomes suggested that the molecules H5, H13, H15 and H18 possessed moderate to promising activity against the selected species of microbial strains having MIC range 7.3 µM to 26.3 µM. The results of anticancer evaluation revealed that all the screened derivatives possess mild anticancer potential. The in-silico ADME studies revealed that all the compounds were found to be drug-like.
Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study
Authors: Nkeck Jan René , Ida Chemgne Marie , Koe Valerie Ndobo , Ndam Antonin Wilson Ndjitoyap , Jessica Yondo Ndedi Claudine , Manuella Eko Ondoa , Charelle Boukeu Yonta , Corine Zouague Zalbi , Andrée Ntyam Abena , Amazia Falmata , Nkeck Jériel Pascal , Samba Esther Astrid Mbono , Moor Vicky Jocelyne Ama
Published: September 2022

Objective

The usefulness of gamma glutamyl transferase (GGT) as biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. To evaluate their relevance on CVR assessment in non-diabetic hypertensive Cameroonians. This was a prospective cross-sectional study on non-diabetic hypertensive adults aged 57.7 ± 10 years (62% female), without evidence of acute or chronic liver disease, in which we assessed GGT levels and correlates it with validated CVR biomarkers, CVR scores (WHO risk score, Framingham 2008, ASCVD 2013, EuroSCORE 2003, and Reynolds score), and plasma atherogenic index (PAI).

Results

We found a positive but weak association between GGT and PAI on linear regression [0.004 (0.001; 0.007); p = 0.021], which was dependent of triglycerides levels (r = 0.17; p = 0.03). We did not find a significant association between GGT levels and the results of the CVR scores studied; Although being related to atherogenic risk, as reported in literature in non-sub-Saharan Africans, GGTs would be of little value for CVR assessment in our population.
Identifying dietary patterns across age, educational level and physical activity level in a cross-sectional study: the Tromsø Study 2015 - 2016
Authors: Moe Åse Mari , Sørbye Sigrunn H. , Hopstock Laila A. , Carlsen Monica H. , Løvsletten Ola , Ytterstad Elinor
Published: September 2022

Background

A healthy diet can decrease the risk of several lifestyle diseases. From studying the health effects of single foods, research now focuses on examining complete diets and dietary patterns reflecting the combined intake of different foods. The main goals of the current study were to identify dietary patterns and then investigate how these differ in terms of sex, age, educational level and physical activity level (PAL) in a general Nordic population.

Methods

We used data from the seventh survey of the population-based Tromsø Study in Norway, conducted in 2015-2016. The study included 21,083 participants aged $$40-99$$

40
-
99

years, of which $$72\%$$

72
%

completed a comprehensive food frequency questionnaire (FFQ). After exclusion, the study sample included 10,899 participants with valid FFQ data. First, to cluster food variables, the participants were partitioned in homogeneous cohorts according to sex, age, educational level and PAL. Non-overlapping diet groups were then identified using repeated hierarchical cluster analysis on the food variables. Second, average standardized diet intake scores were calculated for all individuals for each diet group. The individual diet (intake) scores were then modelled in terms of age, education and PAL using regression models. Differences in diet scores according to education and PAL were investigated by pairwise hypothesis tests, controlling the nominal significance level using Tukey’s method.

Results

The cluster analysis revealed three dietary patterns, here named the Meat and Sweets diet, the Traditional diet, and the Plant-based- and Tea diet. Women had a lower intake of the Traditional diet and a higher preference for the Plant-based- and Tea diet compared to men. Preference for the Meat and Sweets diet and Traditional diet showed significant negative and positive trends as function of age, respectively. Adjusting for age, the group having high education and high PAL compared favourably with the group having low education and low PAL, having a significant lower intake of the Meat and Sweets and the Traditional diets and a significant higher intake of the Plant-based- and Tea diet.

Conclusions

Three dietary patterns (Meat and Sweets, Traditional, and Plant-based- and Tea) were found by repeated clustering of randomly sampled homogeneous cohorts of individuals. Diet preferences depended significantly on sex, age, education and PAL, showing a more unhealthy dietary pattern with lower age, low education and low PAL.
Physical Health Impairment and Exercise as Medicine in Severe Mental Disorders: A Narrative Review
Authors: Brobakken Mathias Forsberg , Nygård Mona , Wang Eivind
Published: September 2022

Background

Individuals with severe mental disorders (SMDs; schizophrenia spectrum disorders, bipolar disorder, and major depressive disorder) are not only suffering from their mental conditions; they also have an attenuated physical health, augmenting their overall critical condition.

Objectives

We review and critically appraise the evidence based on (1) key physiological factors relating to aerobic endurance and skeletal muscle strength; (2) implications for physical function and health; and (3) effects of training interventions with different intensities evaluated in individuals with SMDs.

Findings

Reductions in aerobic endurance factors, peak oxygen uptake (VO2peak) and walking work efficiency, are paralleled by reductions in maximal skeletal muscle strength and power. In turn, the poor aerobic endurance and muscle strength lead to impaired physical function, increased risk of lifestyle-related diseases, and ultimately early death. Exercise has the potential to counteract the attenuated physical health in people with SMDs. While aerobic endurance training is shown to increase VO2peak due to plasticity of the oxygen transport system, strength training is documented to improve maximal muscle strength, power, and walking work efficiency as a result of adaptations in neuromuscular force developing factors.

Conclusions

In conclusion, improvements in these key determinants for physical health appear to be achievable in people with SMDs despite many being challenged by motivational difficulties with attending regular exercise and have beneficial implications for physical function during activities of daily living, lifestyle-related diseases, and early death.
Normative Values for Sport-Specific Left Ventricular Dimensions and Exercise-Induced Cardiac Remodeling in Elite Spanish Male and Female Athletes
Authors: Boraita Araceli , Díaz-Gonzalez Leonel , Valenzuela Pedro L. , Heras María-Eugenia , Morales-Acuna Francisco , Castillo-García Adrián , Lucia María J. , Suja Pedro , Santos-Lozano Alejandro , Lucia Alejandro
Published: September 2022

Background

There is debate about the magnitude of geometrical remodeling [i.e., left ventricle (LV) cavity enlargement vs. wall thickening] in the heart of elite athletes, and no limits of normality have been yet established for different sports. We aimed to determine sex- and sport-specific normative values of LV dimensions in elite white adult athletes.

Methods

This was a single-center, retrospective study of Spanish elite athletes. Athletes were grouped by sport and its relative dynamic/static component (Mitchell’s classification). LV dimensions were measured with two-dimensional-guided M-mode echocardiography imaging to compute normative values. We also developed an online and app-based calculator (https://sites.google.com/lapolart.es/athlete-lv/welcome?authuser=0) to provide clinicians with sports- and Mitchell’s category-specific Z-scores for different LV dimensions.

Results

We studied 3282 athletes (46 different sports, 37.8% women, mean age 23 ± 6 years). The majority (85.4%) showed normal cardiac geometry, particularly women (90.9%). Eccentric hypertrophy was relatively prevalent (13.4%), and concentric remodeling or hypertrophy was a rare finding (each < 0.8% of total). The proportion of normal cardiac geometry and eccentric hypertrophy decreased and increased, respectively, with the dynamic (in both sexes) or static component (in male athletes) of the sport irrespective of the other (static or dynamic) component. The 95th percentile values of LV dimensions did not exceed the following limits in any of the Mitchell categories: septal wall thickness, 12 mm (males) and 10 mm (females); LV posterior wall, 11 mm and 10 mm; and LV end-diastolic diameter, 64 mm and 57 mm.

Conclusions

The majority of elite athletes had normal LV geometry, and although some presented with LV eccentric hypertrophy, concentric remodeling or hypertrophy was very uncommon. The present study provides sport-specific normative values that can serve to identify those athletes for whom a detailed examination might be recommendable (i.e., those exceeding the 95th percentile for their sex and sport).
An overview of the “Protecting Cantonese Movement” in Guangzhou (2010–2021)
Authors: Li Yaling , Kang Yeqin , Ding Dan , Zhang Nianqing
Published: September 2022

A decade ago, an online survey resulted in the “Protecting Cantonese Movement” (PCM) in Guangzhou, Guangdong Province, China, around which some articles were produced. Based on the bibliometric analysis of data retrieved from the China National Knowledge Infrastructure (CNKI), the Web of Science, and Google Scholar keyword searches during 2010 and 2021, this paper reviews the PCM literature to summarize its major features and general trends. It reveals that the published journals or newspaper articles focus on interpretating PCM, analyzing its causes from sociocultural, sociolinguistic, socioeconomic and media environmental perspectives, and proposing countermeasures and suggestions at political, ideological and sociolinguistic environmental levels. It concludes that PCM is of far-reaching significance to the continuous research ranging from Cantonese preserving, promotion of Mandarin, language planning, language policy, and language conflict to language ecology.
Physiotherapeutic evaluation of patients with post COVID-19 condition: current use of measuring instruments by physiotherapists working in Austria and South Tyrol
Authors: Spiegl Claudia , Schiefermeier-Mach Natalia , Schifferegger Erika , Wiederin Claudia , Scheiber Barbara
Published: September 2022

Background

The implementation of standardized assessments in physiotherapeutic practice strongly supports diagnostic and treatment plans. Previous studies reported insufficient usage of standardized assessments due to lack of time, lack of knowledge, lack of resources and other barriers. Physiotherapy in outpatient settings became essential for the rehabilitation of patients with post COVID-19 condition but it remains unknown to what extent assessments are implemented into the evaluation of these patients. In this study, we explored the current use and barriers regarding the implementation of physiotherapeutic assessments to evaluate patients with post COVID-19 condition.

Methods

A cross-sectional online survey was carried out among 180 physiotherapists working in outpatient settings in Austria and South Tyrol.

Results

The majority of physiotherapists (88%) indicated that standardized assessments are useful, though less than a fifth of participants actually implement assessments in practice. Among implementation barriers, “insufficient experience” (41.8%) and “lack of knowledge” (36.6%) were mentioned most often. Concerning specific post COVID-19 assessments, the evaluation of “physical and respiratory function”, “quality of life” and “activities of daily living” were stated to be of particular relevance.

Conclusions

Our study revealed a low implementation rate and identified the main barriers regarding the non-usage of standardized assessments for post COVID-19 patients.

Trial registration

The Private University for Health Sciences and Health Technology (UMIT TIROL), and the Research Committee for Scientific Ethical Questions granted approval for the survey (RCSEQ, Hall in Tirol, Austria, Number 2834).
Anesthetic management in a patient with severe tracheal stenosis by monitoring oxygen reserve index
Authors: Matsuba Sho , Sawai Mitsuki , Higashitani Saki , Sawasaki Fumiya , Kida Hiromasa , Takahashi Kan
Published: September 2022

Background

General anesthesia for tracheal stenting is challenging because of difficult ventilation and accompanying hypoxia. We report the use of oxygen reserve index (ORi™) during tracheal stenting.

Case presentation

Cauterization of an intratracheal tumor and tracheal stenting was scheduled in a patient. ORi decreased from 0.3 to 0.2 after starting cauterization using a flexible bronchoscope through a tracheal tube with 28% oxygen, while SpO2 was maintained at 100%. ORi further decreased to 0, followed by a decrease of SpO2 < 90%, and surgery was interrupted. SpO2 was increased shortly after increasing FiO2 to 1.0, but ORi remained 0 when surgery was resumed; it was increased after completion of cauterization. Both ORi and SpO2 were maintained above 0.4 and 98%, respectively, during tracheal stenting through a rigid bronchoscope under intrapulmonary percussive ventilation.

Conclusion

ORi was useful for predicting a decrease of SpO2 under general anesthesia for tracheal stenting.
The relationship between coping strategies and life quality in major depressed patients
Authors: Bianca Crecan-Suciu D. , Ramona Păunescu L. , Ioana Micluţia V.
Published: September 2022

Background

The present study aimed to explore, for a better understanding, the relationship between dysfunctional coping mechanisms, functionality, and quality of life in patients with major depression, during an acute episode and euthymic phase. 65 patients diagnosed with recurrent major depressive disorder were included in a longitudinal study, during which they were evaluated twice, clinically, for coping mechanisms, and also for different life quality areas. For the first time, all patients were assessed during an acute depressive episode and for the second time after 6 months of euthymia. Coping mechanisms were assessed with the Brief COPE scale, the severity of depression was evaluated by the Hamilton Depression Rating Scale-17 items, the quality of life with the WHOQOL-Bref, and the functionality with GAF.

Results

The coping mechanisms, represented by self-distraction and self-blame, were identified as being significantly correlated with the areas of life quality, mental health, and general environment, for patients having an acute depressive episode. In the euthymic phase of major depression, all dysfunctional coping strategies showed statistically significant associations with the quality-of-life domains and the coping mechanism represented by disengagement was significantly correlated with the global functionality.

Conclusions

Regardless of the current mood state, acute depression or euthymic phase, the dysfunctional coping mechanisms influence the level of life quality domains.
Effect of Ado-Trastuzumab Emtansine on Autologous Platelet Kinetics and Function
Authors: Ansary Ali M. , Stolla Moritz , Corson Jill , Cundy Arianne , Bailey S. Lawrence , Pellham Esther , Bawcom-Randall Morgan , Slichter Sherrill J. , Gadi Vijayakrishna K.
Published: September 2022

PURPOSE

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of decreased platelet production. The current observational study was initiated to evaluate causes of thrombocytopenia in patients with metastatic breast cancer.

MATERIALS AND METHODS

Patients with human epidermal growth factor receptor 2–positive metastatic breast cancer (N = 11) were enrolled in this postmarket safety study. 111-Indium- radiolabeled autologous platelet recoveries and survivals as well as serial platelet counts, bleeding time assays, and platelet aggregation responses to a wide range of agonists were performed at baseline (BL) and during two consecutive cycles of the drug (3.6 mg/kg IV once every 3 weeks).

RESULTS

Platelet nadirs occurred earlier in cycle 2 than in cycle 1. Average nadir counts (% BL) in cycles 1 and 2 were 116,000/µL (53% ± 6%) and 115,000/µL (51% ± 9%), respectively, with return to BL by D15 in both cycles. BL platelet survival averaged 8.8 (± 0.3) days but progressively shortened to 5.5 (± 0.5) days during cycle 1 and to 4.6 (± 0.3) days during cycle 2 ( P < .001 compared with BL for both cycles). Aggregation responses to all agonists decreased during the study, both in cycle 1 and cycle 2.

CONCLUSION

Following T-DM1 administration, we observed statistically significant progressive decreases in platelet survivals and decreased platelet function from BL values. In distinction to published in vitro studies, these unexpected results indicate a direct toxic effect of T-DM1 on patients' autologous circulating platelets.
Poetyckie prowincje i peryferie : Jerzy Harasymowicz i inni
Authors: Kulczyńska Joanna , Ligęza Wojciech , Próchnicki Włodzimierz
Published: September 2022

W omawianej publikacji powraca w nurt dyskursu literaturoznawczego, nieco już dziś zapomniana, twórczość Jerzego Harasymowicza. Zamieszczone w tomie artykuły trafnie eksponują wyjątkowość tego zjawiska nie tylko na mapie literatury polskiej ostatnich dekad XX wieku. Poetą podobnie dziś zapoznanym pozostaje Mieczysław Jastrun, o którym odkrywczo i błyskotliwie pisze jedna z autorek. Znaczący wymiar poznawczy mają teksty o świecie poetyckim Zdzisława Antolskiego i o twórczości poetów Zaolzia. Przybliżenie tych zjawisk kulturowych dzisiejszemu humaniście odświeża dyskurs kulturowy i wprowadza weń akcenty potrzebnego balansu. Znaczącą zaletą omawianej publikacji jest nieoczywistość tematów i wątków podejmowanych przez poszczególnych autorów - począwszy od szkicu na temat ,,ikoniczności" (w dosłownym tego słowa znaczeniu) wymiaru niektórych wierszy Jerzego Harasymowicza, skończywszy zaś na analizie literackich inspiracji w muzyce Henryka Mikołaja Góreckiego. Nieoczywistość oznacza tu - między innymi - transdyscyplinarność oglądu materii poetyckiej i sfery dźwięków, która ujawnia się choćby w wykorzystaniu rozmaitych trybów lektury, narzędzi odbioru dzieła. Mamy więc tu spojrzenie na poezję z punktu widzenia historii sztuki, antropologii kulturowej, filozofii, teorii języka czy - wedle słów jednej z autorek - ,geokrytyki i mitopoetyki". Zebranie tak różnych odczytań utworów poetyckich uważam za dużą wartość omawianego tomu. Z recenzji dr. hab. Witolda Bobińskiego
Posesje elity mieszczańskiej w XIV-XV wieku. Kryteria wyboru
Authors: Goliński Mateusz
Published: September 2022

HOUSING PROPERTIES OF THE BURGHER ELITE IN THE 14TH-15TH CENTURIES SELECTION CRITERIA The article is devoted to the problem of the criteria for the selection of places of residence by urban elites in the Polish lands between the fourteenth and fifteenth centuries. Six criteria were analyzed that were potentially the main determinants of such decisions. They were: the suitability of the property for merchant activity; the possibility of using the property as a source of income; status symbol and comfortable living conditions for a large family and servants; an investment of capital and security for loans; location in space according to group affiliation related to the profession and professional as well as familial connections; and finally, location in space as a manifestation of social and political advancement.
Z Litwy na Górny Śląsk. Helena Korybutówna księżna raciborska i pani na Pszczynie
Authors: Sperka Jerzy
Published: September 2022

FROM LITHUANIA TO UPPER SILESIA HELENA KORYBUTÓWNA , THE DUCHESS OF RACIBÓRZ AND THE LADY OF PSZCZYNA The dynastic ties of the Upper Silesian princes with the Lithuanian Giedyminowiczes developed with the accession of Władysław Jagiełło to the Polish throne. The article is devoted to the marriage that took place in 1407 between Helena, the daughter of Dmitri Korybut of Nowogród, Jagiełło’s niece, and John the Iron of Racibórz. The circumstances of the political career of the Silesian prince and the origin of the Lithuanian princess are presented. The author discusses the political activity of the princely couple in relations with the Polish royal court until the death of John the Iron in 1424. Her participation in the conflict with the Hussites in Silesia is described together with the period after the independence of Nicholas V in the second half of 1428, when Duchess Helena finally settled in Pszczyna for the next 20+ years. The article shows, among other things, her foundations and construction projects in Pszczyna.
Czy Coellnowie byli descendentami Kolnerów i Smogorzowskich? Przyczynek do genealogii rycerstwa śląskiego
Authors: Wójcik Marek L.
Published: September 2022

DID THE COELLNS DESCEND FROM THE KOLNER AND THE SMOGORZOWSKI FAMILIES? CONTRIBUTION TO THE GENEALOGY OF SILESIAN KNIGHTHOOD The article presents the genealogical findings on the Silesian von Coelln and von Schmograu families, which have so far remained on the margins of analytical studies. We see Kolner in Silesia as early as the 13th century. An extremely demanding analysis of family ties with the 13th and 14th centuries in Wrocław and other important centers of social and economic life in Silesia at that time was undertaken. The extensive genealogical description and meticulous genealogical trees of the Kolner and Smogorzowski families show that the identity of the Smogorzów heirs (Smogorzowski) with the lords von Coelln (from Kolno, Stare Kolnie) is established beyond doubt. On the other hand, there is no reason to find their ancestors in Kolner, recorded at the turn of 14th century in the circles of the Wrocław patriciate and local knights.
Pieczęcie cysterskie z opactwa w Łeknie-Wągrowcu (cz. IV)
Authors: Stróżyk Paweł
Published: September 2022

CISTERCIAN SEALS FROM THE ABBEY IN ŁEKNO -WĄGROWIEC (PART IV) The article is the next, fourth, part of the study of the Cistercian seal from the Cistercian Abbey in Łekno-Wągrowiec in Greater Poland. The text revisits the issue of the early modern seals of the convent in Wągrowiec, analyzed by Paweł Stróżyk. A comparison was made of the patterns of seals used in the monastery from the 16th century onwards. An analysis was made of the differences that existed between them as well as the impact of these discoveries on the dating of the seals. It is worth noting that the article was inspired by the discovery in 2021 of the 18th-century stamp of the seal of the convent in Wągrowiec, reported by the State Archives in Poznań, which keeps it in its collection.
Cursus dokumentu Władysława Hermana dla Bambergu. Przyczynek do badań nad rytmiką wczesnych dokumentów
Authors: Jasiński Tomasz
Published: September 2022

THE CURSUS OF WŁADYSŁAW HERMAN’S DOCUMENT FOR BAMBERG CONTRIBUTION TO RESEARCH ON THE RHYTHM OF EARLY DOCUMENTS In historiography, rhythmics is considered particularly useful for narrative research. When it comes to documents, historians most often limit themselves to perfunctory remarks about the role of cursus. The article is devoted to this kind of sources. In documents and normative acts, cursus appeared long before the generally indicated end of the 11th century. For the first time in its pure form, it appears in the law office of Constantine the Great in the 310s. The article analyzes the rhythm of the texts related to the history of Poland. The author proves that studying the rhythm of documents leads to unexpected findings and, above all, allows to deepen the methods of analysis. Studies of documents from the first quarter of the 12th century in the famous Reichenau monastery are described. Among the texts of this provenance, one could be by Gaul Anonymus. It is distinguished by its rhythm and quality similar to that in the Polish Chronicle. The last part of the article analyzes the rhythm of the oldest surviving Polish document, issued by Władysław Herman for the Bamberg Chapter.
Kilka nieznanych testamentów chłopów czukiewskich z końca XVIII w.
Authors: Łosowski Janusz
Published: September 2022

SEVERAL UNKNOWN WILLS OF THE CZUKIEW PEASANTS FROM THE END OF THE 18TH CENTURY The article is devoted to the unknown wills of the Czukiew peasants from the end of the 18th century, which are presented in a source edition in its second part. The number of testaments drawn up allows to rank Czukiew among villages where the awareness of the need to record in writing the ordinances of the last will was relatively well developed. In 1633-1793, on the initiative of Czukiew peasants, 20 last-will documents were written, most of which were drafted in the second half of the 18th century. The five testaments analyzed in the article originate from 1796-1800. The article describes the circumstances of the preparation of these wills and the social and cultural context in which they were created.
Czy powstanie polska baza poloniców?
Authors: Zdrenka Joachim
Published: September 2022

WILL THERE BE A POLISH DATABASE OF POLONICA? The article deals with the problem of the huge dispersion of historical material and the enormous research possibilities that lie dormant in these as yet unrecognized sources. There are examples of resources at Deutsche Staatsbibliothek in Berlin, Central Military Library in Warsaw, Ratsbibliothek in Lüneburg, Stadtarchiv in Worms, Royal Library in Stockholm, and many others, which are listed at the end of the article. The author suggests developing a source database of broadly understood polonica, which could be created in cooperation with the Head Office of State Archives.
Próby reaktywowania działalności Kościoła greckokatolickiego w Polsce w latach 1947-1958
Authors: Drozd Roman
Published: September 2022

ATTEMPTS TO REACTIVATE THE ACTIVITY OF THE GREEK CATHOLIC CHURCH IN POLAND IN 1947-58 The article presents attempts to reactivate the activity of the Greek Catholic Church in Poland in 1947-58. The process of liquidating the structures of the Greek Catholic Church in 1947 and the special powers that Cardinal August Hlond received in this respect are presented. The author shows the fate of Greek Catholics during the period of displacement within the ‘Vistula Operation’ and the attitude of the Roman Catholic hierarchy to their relocation. An attempt to include Greek Catholics in the Orthodox Church in the early 1950s is also described, as well as the new possibilities of changing the situation of the clergy and Greek Catholic faithful after 1956. Ultimately, the Roman Catholic hierarchy agreed to hold Greek Catholic services in the western and northern territories of Poland within the Roman Catholic Church, but no consent was given to creating its structures. The reconstruction of the structures of this Church took place only in 1990.
Consumer Fairness Concerns and Dynamic Pricing in a Channel
Authors: Diao Wen , Harutyunyan Mushegh , Jiang Baojun
Published: September 2022

Effect of consumer fairness concerns on wholesale and retail price dynamics and manufacturer and retailer profits.
An audit of sharps injuries in clinical skills simulation wards at a UK university
Authors: Hambridge Kevin , Endacott Ruth , Nichols Andrew
Published: September 2022

Background/Aims

Healthcare students are at high risk of sharps injuries, which can negatively impact their confidence and wellbeing. This study audited three clinical skills simulation wards at a UK university to determine the incidence of sharps injuries in this educational setting.

Methods

An audit of sharps injuries sustained in three clinical skills simulation wards was conducted, including data from 2008–2016. The authors developed an audit tool to collect data on the number of incidents that occurred, the type of individual involved and the nature of the incident. Results were analysed to compare the incidence of general injuries and sharps injuries among healthcare students and staff.

Results

A total of 46 incidents were recorded across the three wards during the 8-year period. Sharps injuries were by far the most common type of injury, comprising 69.6% of recorded incidents, followed by fainting at 19.6%. The highest proportion of general injuries (56.5%) and sharps injuries (59.4%) occurred among nursing students. However, the association between incidents and type of individual involved was not statistically significant

Conclusions

Sharps injuries were the most common type of incident in the clinical skills simulation wards, with student nurses being at highest risk. Intervention is needed to improve safety in this educational setting, including sharps handling training, with greater focus on existing regulations.
Statins: setting the record straight
Authors: Richardson Andy
Published: September 2022

Andy Richardson, lecturer in adult nursing, explains how media misrepresentation of statins has impacted patients and the wider public, and what healthcare professionals can do to mitigate this.
Interceptive management of increased overjet in young children: a clinical protocol
Authors: Smyth Robert SD , Patel Khushbu , Ashley Paul , Noar Joseph H
Published: September 2022

This article describes the different techniques for the management of an increased overjet in a child considered too young for conventional orthodontics, as well as the clinical situations in which these techniques may be useful. This is particularly aimed at general dental practitioners and paediatric dentists working in areas with limited access to specialist orthodontic services.

CPD/Clinical Relevance: Knowledge of techniques for early management of an increased overjet in young children is of interest.
Monkeypox and the dental team
Authors: Samaranayake Lakshman , Anil Sukumaran
Published: September 2022

Monkeypox (MPX), a rare zoonotic disease, endemic to some African countries is now spreading in non-endemic regions, including the UK. So far, it has been reported in 93 countries with over 38,000 global cases, although the signs are that the disease may be plateauing in UK. The outbreak was declared a public health emergency of international concern by the World Health Organization (WHO). Monkeypox virus (MPXV), belongs to the family Orthopoxviridae, the same family as the smallpox (variola) virus. Although some features of MPX resemble smallpox, a disease that has been eradicated, the former is far milder with a very few associated fatalities. Usually, the initial signs of MPX appear during its prodrome, as single or multiple macular lesions on the oral mucosa, accompanied by generalized lymphadenopathy, followed by the characteristic macular, papular vesicular rash on the skin that heals with scarring. The major mode of spread of MPX is generally through direct or indirect contact with body fluids or lesion material. Its transmission in the dental clinic environment is unlikely if the standard infection prevention and control (IPC) precautions recommended in the National IPC Manual (NHS England) are adhered to. These include wearing N95 masks, fluid-resistant attire and eye protection. Here, the virology, clinical manifestations, diagnosis, management and prevention strategies of MPX, with particular reference to dentistry are reviewed.

CPD/Clinical Relevance: To describe the epidemiology of the re-emergent monkeypox outbreak, and discuss the management of dental patients who may present with it.
Comparing Examination Standards without Graded Candidate Scripts
Authors: Jones Ian , Foster Colin , Hunter Jodie
Published: September 2022

Comparative judgement methods are commonly used to explore standards in examination papers over time. However, studies are limited by a paucity of graded candidate scripts from previous years, as well as the expense and time required to standardise scripts. We present three studies that attempted, without the use of graded candidate scripts, to replicate and extend previous results about standards in mathematics examination papers. We found that re-typesetting examination papers into a consistent format was necessary, but that comparative judgement of examination papers without an archive of graded candidate scripts offered a reliable and efficient method for revealing relative demand over time. Our approach enables standards comparison where previously this was not possible. We found a reasonable correlation between judgments of actual student scripts and judgments of the items only, meaning that conclusions may be drawn about the demand of examination papers even when graded candidate scripts are not available.
FATORES DETERMINANTES PARA O SUCESSO DE BILHETERIA DE FILMES NO BRASIL
Authors: Anaz Sílvio
Published: September 2022

Estudos internacionais mostram que os principais fatores correlacionados ao sucesso de bilheteria de um filme são: familiaridade cultural, gênero, orçamento, distribuição, elenco, direção, premiações e recepção pela crítica. Este artigo analisa qual é o impacto desses fatores no desempenho de bilheteria em 40 filmes internacionais e nacionais lançados entre 2010 e 2019. Para tanto, faz a revisão da literatura e emprega a técnica estatística do agrupamento hierárquico aglomerativo. Resultados indicam que familiaridade cultural, orçamento e gêneros de ação e aventura são determinantes para o sucesso no Brasil, enquanto premiações não.
UM PASSEIO PELOS ESCOMBROS: cenas testemunhais da pandemia de Covid-19 no contexto negacionista brasileiro
Authors: Vaz Frances , Salgueiro Marques Ângela Cristina
Published: September 2022

O artigo objetiva analisar cenas testemunhais da pandemia de Covid-19 no Brasil compartilhadas pelo perfil @covidphotobrazil, no Instagram, em março de 2021. O atual cenário do negacionismo pandêmico brasileiro é discutido à luz dos debates contemporâneos sobre processos de erosão democrática em que se verifica, dentre outros aspectos, o uso sistemático da mentira, tomando o negacionismo pandêmico como uma as formas pelas quais o governo brasileiro investe em uma agenda de mentira e desinformação. Esse processo resulta no apagamento das vidas e histórias dos que adoeceram e morreram, culminando no esquecimento e na dificuldade em se produzir uma memória social do atual momento. As cenas testemunhais são analisadas à luz dessas discussões, da crítica ao historicismo de Walter Benjamin e das noções de precarização de determinadas vidas de Judith Butler, constituindo-se, portanto, como registros da história dos sobreviventes e como política da memória contra o esquecimento.
A checklist of social wasps (Vespidae: Polistinae) from Tocantins state, Brazil
Authors: Furtado Lucas Bezerra , Somavilla Alexandre , Krolow Tiago Kütter
Published: September 2022

Tocantins state has high biodiversity and a high degree of endemism, nevertheless, there are no studies on the diversity of social wasps. This study introduces a survey of social wasps actively collected using entomological nets and Malaise trap in addition to different light traps in sixteen sites in the Amazon and Cerrado biomes in Tocantins state, Brazil. We sampled a total of 1,013 social wasps distributed in 57 species of 13 genera. Fifty of these species and nine genera represent new distribution records for the state. Some species are not commonly found in collections and lists of species, and Protopolybia picteti (de Saussure, 1854) is newly recorded for Brazil. Such an increase of 714% may indicate that Polistinae richness is probably higher in the studied regions and that the state of Tocantins may well contain several additional (yet unrecorded) social wasp species. More comprehensive studies should be conducted to enhance the knowledge of wasp species in this state, contributing to our understanding of the biodiversity in Northern Brazil.
A guide to open science practices for animal research
Authors: Diederich Kai , Schmitt Kathrin , Schwedhelm Philipp , Bert Bettina , Heinl Céline
Published: September 2022

Translational biomedical research relies on animal experiments and provides the underlying proof of practice for clinical trials, which places an increased duty of care on translational researchers to derive the maximum possible output from every experiment performed. The implementation of open science practices has the potential to initiate a change in research culture that could improve the transparency and quality of translational research in general, as well as increasing the audience and scientific reach of published research. However, open science has become a buzzword in the scientific community that can often miss mark when it comes to practical implementation. In this Essay, we provide a guide to open science practices that can be applied throughout the research process, from study design, through data collection and analysis, to publication and dissemination, to help scientists improve the transparency and quality of their work. As open science practices continue to evolve, we also provide an online toolbox of resources that we will update continually.
The osteogenetic activities of mesenchymal stem cells in response to Mg2+ ions and inflammatory cytokines: a numerical approach using fuzzy logic controllers
Authors: Nourisa Jalil , Zeller-Plumhoff Berit , Willumeit-Römer Regine
Published: September 2022

Magnesium (Mg2+) ions are frequently reported to regulate osteogenic activities of mesenchymal stem cells (MSCs). In this study, we propose a numerical model to study the regulatory importance of Mg2+ ions on MSCs osteoblastic differentiation in the presence of an inflammatory response. A fuzzy logic controller was formulated to receive the concentrations of Mg2+ ions and the inflammatory cytokines of TNF-α, IL-10, IL-1β, and IL-8 as cellular inputs and predict the cells’ early and late differentiation rates. Five sets of empirical data obtained from published cell culture experiments were used to calibrate the model. The model successfully reproduced the empirical data regarding the concentration- and phase-dependent effect of Mg2+ ions on the differentiation process. In agreement with the experiments, the model showed the stimulatory role of Mg2+ ions on the early differentiation phase, once administered at low concentration, and their inhibitory role on the late differentiation phase. The numerical approach used in this study suggested 6–8 mM as the most effective concentration of Mg2+ ions in promoting the early differentiation process. Also, the proposed model sheds light on the fundamental differences in the behavioral properties of cells cultured in different experiments, e.g. differentiation rate and the sensitivity of the cultured cells to stimulatory signals such as Mg2+ ions. Thus, it can be used to interpret and compare different empirical findings. Moreover, the model successfully reproduced the nonlinearities in the concentration-dependent role of the inflammatory cytokines in early and late differentiation rates. Overall, the proposed model can be employed in studying the osteogenic properties of Mg-based implants in the presence of an inflammatory response.
Perceptions and attitudes of ICU physicians toward antibiotics prescribing and resistance: A cross-sectional study
Authors: Shendy Esraa Mahrous , Elberry Ahmed A. , Hamed Mohamed Lamia , Boshra Marian S.
Published: September 2022

Background and aim

Antibiotic resistance is a major emphasis in intensive care units (ICUs). Better understanding of ICU physicians’ perceptions, attitudes, and knowledge about antimicrobial prescribing practices could facilitate more effective interventions in fighting antimicrobial resistance in Egyptian ICUs and establishing a proper Antimicrobial Stewardship Program.

Methods

A cross-sectional questionnaire study was conducted including 92 physicians distributed across the different types of Egyptian healthcare institutions in two cities of Egypt; Cairo and El Monufia. Over a period of three months, started in December 2019 and ended in February 2020.

Results

A total of 92 Egyptian physicians were included in the study. Seventy (76.1%) of the surveyed physician strongly agreed and 22 (23.9%) agreed that antibiotic resistance is a worldwide problem. Moreover, 50 (54.3%) strongly agreed and 40 (43.4%) agreed that it is a problem in their hospitals while only 2 (2.1%) disagreed. Poor hand hygiene (67.5%), poor infection control practices by healthcare professionals (63.9%) as well as wrong practices in the management of invasive devices (68.7%), and poor environmental cleaning practices (63.4%) were considered very important causes of AMR by the majority of the surveyed ICU physicians. Almost all of the physicians (95%) rated an advice from a clinical pharmacist as very or moderately helpful intervention, while (52%) declared an advice from a microbiologist or an infectious disease specialist as very helpful.

Conclusion

The results of the present study showed that the Egyptian ICU physicians have remarkable knowledge regarding antibiotic resistance as a worldwide problem and a high sensibility toward the problem in their hospitals. The study also showed that implementation of proper AMS is an urgent need as physicians answers for the different questions in the survey showed that their attitudes and perceptions regarding antibiotic resistance and their way in prescription could be modified and improved if AMS programs with suitable training programs and local guidelines are provided among different types of Egyptian hospitals.
Anticipated stigma and associated factors among chronic illness patients in Amhara Region Referral Hospitals, Ethiopia: A multicenter cross-sectional study
Authors: Salih Mohammed Hassen , Mekonnen Hussen , Derseh Lema , Lindgren Helena , Erlandsson Kerstin
Published: September 2022

Background

Anticipated stigma related to chronic illness patients undermines diagnosis, treatment, and successful health outcomes. The study aimed to assess the magnitude and factors associated with anticipated stigma among patients with chronic illness attending follow-up clinics in Amhara Region Referral Hospitals, Ethiopia.

Methods

A cross-sectional institution-based study was conducted in Amhara Region Referral Hospitals from 01 March to 15 April 2021. A simple random sampling technique was used to select the three Referral Hospitals in the region and study subjects. Data were collected using a pre-tested interview-based questionnaire. Data were entered and cleaned with Epi-Info version 6 and exported for analysis STATA version 14. Multiple linear regression was used to show the association between anticipated stigma and potential factors. Associations were measured using ß coefficients and were considered statistically significant if the p-value > 0.05.

Results

A total of 779 patients were included for analysis with a response rate of 97%. Their mean (Standard deviation) of anticipated stigma was estimated at 1.86 and 0.5, respectively. After running an assumption test for multiple linear regression; educational status, cigarette smoking, psychological distress, medication adherence, alcohol consumption, and social part of the quality of life were statically significantly associated with anticipated stigma.

Conclusion and recommendation

The result showed a high level of anticipated stigma reported among the participants. Emphasizing improving their social part of the quality of life, avoiding risky behaviors like alcohol consumption and cigarette smoking, access to health education for chronically ill patients, integrating mental health in all types of chronic disease, and developing strategies and protocols which will help to improve patient medication adherence to their prescribed medication will be crucial. This can provide a foundation for government andnon-governmental organizations, and researchers implementing evidence-based interventions and strategies on chronic care to address factors related to anticipated stigma.
Examining the causal relationships between interpersonal motivation, engagement, and academic performance among university students
Authors: Ito Takamichi , Umemoto Takatoyo
Published: September 2022

This study investigates the validity of path models in which interpersonal motivation positively predicts behavioral, emotional, and cognitive engagement, and behavioral engagement positively predicts superior performance in collaborative learning in university classes. The path model was tested using structural equation modeling. The results of the analyses showed that weak positive paths from identified regulation to all three aspects of engagement were substantial. In addition, a weak positive path from intrinsic motivation was significant for emotional engagement. For performance, the weak positive path from behavioral engagement was statistically significant. Based on these results, the implications of the motivation theory and practice in higher education are discussed.