bluuebunny/crossref_metadata_2025 huggingface dataset:
ВМГВ – КАК БИОМАРКЕРЫ СОСТОЯНИЯ ОКРУЖАЮЩЕЙ СРЕДЫ
Authors: Сапарбиева Х.Ш. , Джамбетова П.М.
Published: February 2022

Среди основных экологических проблем значимое место занимает прогноз генетических последствий загрязнения окружающей среды. Врожденные дефекты являются основной причиной детской заболеваемости и смертности во всем мире. В работе рассматривается использование врожденных морфогенетических вариантов в качестве биомаркеров загрязнения среды проживания мутагенными и тератогенными факторами, оказывающими влияние на развитие человека в эмбриональном периоде. Подавляющее большинство врожденных дефектов несиндромны, и, хотя их этиология остается в основном неизвестной, данные подтверждают гипотезу о том, что они являются результатом сложного взаимодействия генетических, эпигенетических, факторов окружающей среды и образа жизни.
РАСПРЕДЕЛЕНИЕ ВИДОВ СЕМЕЙСТВА «ОСОКОВЫЕ» ЧЕЧЕНСКОЙ РЕСПУБЛИКИ ПО ФЛОРИСТИЧЕСКИМ РАЙОНАМ
Authors: Ирисханова З.И. , Молочаева Л.Г.
Published: February 2022

В настоящем сообщении дан анализ распределения видов семейства Осоковых по флористическим районам Чеченской Республики. Виды данного семейства иногда считают растениями минимальной практической важности. Они обитают в различных средах обитания от тропиков до арктических регионов, особенно часто они преобладают на водно-болотных угодьях. Гидрофиты, гелофиты, мезофиты, или ксерофиты. Космополитичное семейство, населяющее разнообразные среды обитания, с предпочтением открытой местности и водно-болотных угодий. Анализ приведен на основе обработки гербарных материалов кафедры «Ботаника, зоология и биоэкология» Чеченского государственного университета им. А.А. Кадырова и полевых наблюдений.
EFFECTIVENESS OF EMPLOYEE RESILIENCE AMONG INFORMATION TECHNOLOGY SECTOR EMPLOYEES: AN EMPIRICAL STUDY
Authors: Mr. P Sai Kumar  , Dr. V. Tulasi Das
Published: February 2022

COVID-19 had a global impact on most organizations’ operations and workforce, particularly with regard to safety, mobility, productivity, engagement, and security. The biggest challenge of IT companies face today is managing virtual work, while balancing employee safety with company security. They must sustain secured operations and adopt new collaborative strategies to maintain workforce productivity. Looking ahead, companies must make business resiliency a continuous process. This pandemic represents an opportunity for Companies to make rapid, well-informed decisions and expedite arrangements to safeguard their workforce, mitigate business disruption, and ensure that critical operations continue. An informed decision could build trust, resiliency, and a culture of innovation; a poor decision could pose a real reputational risk. To enable a more resilient business, IT organizations should focus on individual resilience and this individual resilience ensure resiliency of organisation. Therefore, the current research paper examines the effectiveness of resilience among IT sector employees and present the results.
KEYWORDS: Employee Resilience, Productivity, Virtual Workforce, Sustainability, Strategy.
Media Pembelajaran Vidio dalam Pembelajaran Sejarah
Authors: Santosa Yusuf Budi Prasetya , Irawan Hendi , Hidayat Fahmi
Published: February 2022

Media pembelajaran merupakan salah satu komponen penting dalam proses pembelajaran. Bagi guru penggunaan media pembelajaran dapat membantu dalam menyampaikan materi pelajaran. Sedangkan bagi peserta didik, media pembelajaran dapat membantu memahami materi pelajaran. Salah satu media pembelajaran yang sering digunakan oleh guru adalah media video pembelajaran. Media video pembelajaran dapat memberikan gambaran yang konkret atas gagasan dan ide yang terkandung di dalam materi pelajaran. Mata pelajaran sejarah merupakan salah satu mata pelajaran yang cocok menggunakan video pembelajaran. Penelitian ini bertujuan untuk melihat bagaimana penggunaan media pembelajaran dan bagaimana penerapan media video pembelajaran dalam pembelajaran sejarah. Populasi dan sampel dari penelitian adalah seluruh peserta didik kelas XI IPS di SMA Sejahtera 1 Depok.  Berdasarkan hasil penelitian yang telah dilakukan media video pembelajaran merupakan media yang baik digunakan pada mata pelajaran sejarah. Media video pembelajaran juga dapat meningkatkan efektivitas dan antusiasme pembelajaran peserta didik.
Using Mixed Amino Acids to Aid Healing of Chronic Wounds—A Case Study
Authors: Chang Wei-Lin , Hou Yi-Cheng , Yang Chin-Hsuan , Wu Jing-Huei , Tzeng I-Shaing , Chang Meing-Chung , Lu Chun-Te , Kuo Chan-Yen
Published: February 2022

Supplementation with select nutrients facilitate wound healing, thereby supporting the association between nutrition and wound healing. In recent years, studies have assessed the relationship of amino acid supplements and basic nutrition with wound healing. The present study is a case report on about a 35-year-old woman whose wound measured 0.7 × 1 cm2 after laparoscopic surgery but did not heal for more than 5 weeks after surgery and drainage tube removal. Nutritional care comprising the required calories and a high-protein diet was initiated. The average actual daily calorie intake was 1,556 kcal (88% of the required amount), and the average daily protein intake was 91 g (126% of the required amount). After 11 days on a diet containing mixed amino acids (arginine, glutamine, and beta-hydroxy-beta-methylbutyrate), the wound size reduced from 0.7 × 1 cm2 to 0.3 × 0.5 cm2. The case findings suggest that the provision of sufficient calories and protein nutrition, supplemented with mixed amino acids containing arginine, glutamine, and beta-hydroxy-beta-methylbutyrate can contribute to the healing of chronic wounds.
MENINGKATKAN HASIL BELAJAR MENGOPER PADA SEPAK BOLA MELALUI PENDEKATAN BERMAIN
Authors: Ruslan Ruslan , Amin Moh. Rukhyat
Published: February 2022

Keterampilan mengoper dalam olahraga Sepak bola merupakan sebuah keterampilan dasar yang digunakan dalam memindahkan bola dari satu pemain ke pemain yang lainnya. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang bertujuan untuk meningkatkan hasil belajar mengoper pada permainan Sepak bola melalui pendekatan bermain siswa Kelas XI IPA 3 di SMA Negeri 4 Gorontalo. Subjek penelitian ini adalah siswa-siswi kelas XI IPA 3 SMA Negeri 4 Gorontalo dengan jumlah 34 orang dengan masing-masing 20 orang laki-laki dan 14 orang perempuan dan merupakan penelitian populasi. Teknik pengumpulan data yang terdiri dari observasi, wawancara, dan dokumentasi. Teknik analisis data diolah dengan rumus ketuntasan belajar individu, ketuntasan belajar klasikal, dan daya serap klasikal. Hasil observasi yaitu capaian kategori sangat kurang 11.77%, kurang baik 29.41%, cukup baik 17.64%, baik  26.47%, sangat baik 14.71%, kemudian dilanjutkan dengan siklus I yang mencapai kategori kurang baik 14.71%, cukup baik 20.59%, baik  17.64%, sangat baik 47.06%, kemudian hasil akhir siklus II dari penelitian ini yaitu mencapai kriteria baik 17.65% dan sangat baik 82.35% untuk kriteria ketuntasan penilaian. Pembuktian dari penelitian tersebut menyimpulkan bahwa penggunaan metode bermain yang menyenangkan telah dapat meningkatkan hasil belajar operan pada Sepak bola siswa Kelas XI IPA 3 di SMA Negeri 4 Gorontalo.
A Segurança no Tratamento de Dados Pessoais no Sistema Judicial, em Portugal e no Brasil
Authors: Masseno Manuel David
Published: February 2022

Este artigo expõe, comparativamente, os regimes jurídicos relativos às medidas de segurança no tratamento de dados pessoais em Portugal e no Brasil, depois do Regulamento Geral de Proteção de Dados da União Europeia e da Lei Geral de Proteção de Dados do Brasil. O que é feito tanto em termos gerais, quanto a propósito das especificidades legislativas aplicáveis à Justiça Criminal.
A Aplicabilidade Da Tecnologia Blockchain Às Licitações Públicas
Authors: Cardoso Henrique Ribeiro , Cerqueira Rafael Soares de , Andrade Anne Beatriz Costa de
Published: February 2022

O objetivo do presente estudo é expor o que é a tecnologia blockchain, como ela vem sendo utilizada no Brasil e qual o posicionamento do TCU a respeito da mesma, bem como, analisar a aplicabilidade da referida tecnologia às licitações públicas, de forma a averiguar quais as vantagens da referida inovação, bem como, os seus desafios. Para tanto, foi realizada uma pesquisa exploratória, na qual foram utilizados os métodos de revisão bibliográfica e de análise de documentos. Ao final, verificou-se que a tecnologia em blocos está em ascensão no Brasil e é bastante vantajosa quando aplicada aos certames licitatórios, pois auxilia no combate a fraudes e incidentes de corrupção.
Bioeconomia: A Economia do Futuro, Sob a Ótica dos Objetivos de Desenvolvimento Sustentável
Authors: Pozzetti Valmir César , Ferreira Marie Joan Nascimento , Silva Anderson Solimões
Published: February 2022

O objetivo desta pesquisa é o analisar o conceito de bioeconomia e verificar se esta pode ser um caminho para o alcance dos objetivos do desenvolvimento sustentável da ONU e uma ferramenta essencial para se consolidar os direitos humanos. A metodologia utilizada nessa pesquisa foi a do método dedutivo; quanto aos meios a pesquisa foi bibliográfica e quanto aos fins a pesquisa foi qualitativa. A conclusão a que se chegou foi a de que o conceito de bioeconomia é abrangente, e estimula a sustentabilidade ambiental bem como privilegia os direitos humanos, na busca do pleno emprego e desenvolvimento social e econômico.
Kode Etik Jurnalisik: Sebuah Dilematisasi Bagi Jurnalis
Authors: Wahyudi Gemuh Surya
Published: February 2022

Kode etik jurnalistik sudah disepakati bersama oleh organisasi wartawan dan telah ditetapkan oleh dewan pers. Kode Etik Jurnalistik juga tertuang dalam Undang-Undang Republik Indonesia Nomor 40 tahun 1999 Pasal 7 Ayat 2, yang berbunyi “wartawan memiliki dan mentaati kode etik jurnalistik”. Kode etik jurnalistik dibentuk atas dasar untuk menjamin kemerdekaan pers dan juga untuk memenuhi hak publik dalam memperoleh informasi yang benar, wartawan Indonesia memerlukan landasan moral dan etika profesi sebagai pedoman operasional dalam menjaga kepercayaan publik dan menegakkan integritas secara profesional. Kode etik terdiri dari sebelas (11) pasal yang masing-masing pasal memiliki penafsirannya masing-masing. Idealnya etika jurnalistik harus dilaksanakan sesuai dengan kode etik jurnalistik tapi kenyataannya banyak dikalangan pelaku media melanggar Kode Etik Jurnalistik.
Mempersoalkan Kembali Produk Jurnalistik di Berbagai Media Saat Ini
Authors: Irawan Rahmat Edi
Published: February 2022

Masalah karya atau produk jurnalistik di berbagai media saat ini, termasuk di televisi teresterial, kembali mengemuka, saat program “Mata Najwa” di Trans7 menayangkan episode ketidakhadiran Menteri Kesehatan pada saat itu, Terawan Agus Putranto, yang diwakili kursi kosong diwawancara oleh presenter Najwa Sihab. Najwa Sihab dengan “Mata Najwa” wajib mmeberikan visual ketidakhadiran Menkes, dengan tampilan dan model wawancara dengan sebuah kursi kosong, 28 September lalu. Meski demikian, apa yang dihadirkan Najwa tersebut, menimbulkan pro dan kontra, apakah cara seperti itudiperbolehkan sebagai sebuah karya jurnalistik? Sebagian kalangan menganggap ini adalah sarkasme jurnalistik, yang memang perlu hadir sebagai bentuk tekanan terhadap pejabat publik yang sehrusnya terbuka kepada publik dan media, sebagai bentuk tanggungjawab karena dirinya digaji oleh Media192publik. Sementara sebagain lainnya menganggap, bahwa apa yang dilakukan Najwa sudah melanggar etika jurnalistik.
Kekerasan Terhadap Jurnalis: Tantangan Bagi Media dan Demokrasi
Authors: Maryani Eni
Published: February 2022

Wacana tentang kekerasan terhadap jurnalis menyadarkan kita bahwa dibalik berita-berita penting yang kita baca, lihat atau dengar terdapat aktor-aktor yang memiliki resiko untuk mewujudkannya. Merujuk pada pemikiran Kant, kerja jurnalis adalah sebuah profesi yangberkaitan dengan upaya memeriksa beragam pengetahuan yang akan dihadirkan ke masyarakat umum. Pengetahuan bukan sesuatu yang diperoleh secara dogmatis tapi melalui pencarian dan proses kritisisme yang didasarkan pada akal budi manusia (Hardiman, 2011; Kant, 2021).
Perubahan Variasi Tokoh dalam Game “Dreadout” (2014) menjadi Film “Dreadout” (2019)
Authors: Rahayu Septiani Puji , Fauziah Mita Ulfia
Published: February 2022

Penelitian ini mengkaji tentang perbedaan variasi yang terjadi pada tokoh dalam game “Dreadout” yang diterbitkan tahun 2014 dengan film “Dreadout” yang diterbitkan tahun 2019. Tujuan dari penelitian ini untuk mengetahui struktur teks dan perubahaan variasi tokoh dalam game ke dalam film “Dreadout”. Metode penelitian yang digunakan adalah dekriptif analisis. Berdasarkan hasil penelitian menunjukkan bahwa terdapat banyak variasi yang terjadi pada tokoh yang merubah alur aslinya. Tidak hanya dilakukan oleh tokoh utama saja, namun perubahan variasi juga terdapat pada beberapa tokoh pembantu.
This study discusses the differences in variations that occur in the characters in the dreadout game published in 2014 and the new dreadout film published in 2019. The purpose of this research is to determine the structure of the text and changes in the variation of the characters in the game into the Dreadout movie. The research method used is descriptive analysis. Based on the results of the study, it shows that many variations occur in the characters that change the proper plot. Not only done by the main character but changes in variations are also found in several supporting characters.
A BURNING: A NOVEL ON INDIAN METROPOLIS ASSIMILATING INDIAN DREAMS BY MEGHA MAJUMDAR
Authors: Joshi Jagidsh , Vyas Sandhya
Published: February 2022

India is the country where diversities are to be found everywhere and that reflects in its art for art has the tendency to reflect the world around. India, with its emergence in industries and technologies, has become the cynosure for many of the authors to portray in their literary masterpieces. With these imitations, many of the writers have concentrated on the aspects of modern India especially its metropolitan life style and their outcomes on social, political and cultural lives of the people or groups of different ethnicities. Illustrations of Indian Metropolis like Bombay, Delhi, Calcutta, and others are become the prominent interests in Indian English writings by New Generation authors. The present paper focuses on one of such masterpieces A Burning: A Novel (2020) by Megha Majumdar. The novel is a stark commentary on the devastating state of contemporary India which assimilates the concept of American dream. With the publications of many such sharp and realistic literature of representing modern India, one can definitely put them in the category of literature of Indian Dreams. The present novel encompasses the components of literature of marginalized nurturing big dreams in a country heading towards extremism. Portraying the lives of three different individuals which are interrelated with each other, Majumdar has shown how every individual is struggling with their own quests of power, fame and self-determination.
GREEN SYNTHESIS, CHRACTERISATION AND ANTIBCTERIAL ACTIVITIES OF TUNGSTEN, TIN AND LEAD NANOPARTICLES BYCUCURBITA MAXIMA (PUMPKIN) FLOWER EXTRACT
Authors:   PG&ResearchDepartment of Chemistry, Government arts college, Chidambaram, Tamilnadu, India-608102, Nivetha S , Sathiyamoorthi Dr. K ,   PG&ResearchDepartment of Chemistry, Government arts college, Chidambaram, Tamilnadu, India-608102, DarlinQuine Dr.S ,   PG&ResearchDepartment of Chemistry, Government arts college, Chidambaram, Tamilnadu, India-608102
Published: February 2022

In this paper, a green synthetic route was developed to synthesize tungsten, tin and lead nanoparticles mediated by the Cucurbita maxima flower extract, Cucurbita is monoecious (unisexual flowers, with male and female on the same plant), bearing solitary actinomorphic flowers (10-20 cm across) that are open for a single day Cucurbita maxima was a traditional vegetable food for south Indian. The flower of Cucurbita maxima aqueous extract is analyzed for the phytochemical constituent. The synthesized nanoparticles are characterized by UV, FTIR, XRD and SEM with EDS. The synthesized three nanoparticles also screened by gram positive and negative bacterial strains.
IT Employees Training Methods and Job Performance - An Empirical Investigation
Authors:   Research Scholar, Bharathiar University, Coimbatore., D Mr. Ramesh , Mohan Dr. N ,   Principal, Sadhguru Sainath Degree College, Kudlu, Bangalore.
Published: February 2022

With the growing body of research in the field of human resource functions this study intends to find the impact of employee’s training methods towards their job performance. The data were gathered from 576 employees working in IT companies at Bangalore. The middle level employees were chosen as the samples. The PLS based approach is used to test the proposed hypotheses. The training methods is categorized in two forms as On-the Job training (OJT) and specialized training and its influence towards the job performance is assessed. Based the research framework formulated the findings of the study claimed that both the training methods showed a positive influence towards the employee’s job performance. Specifically, the specialize training shows greater impact on performance of the employees than that of other training methods. Further the study also suggests managerial implications by helping the management in realizing the importance of specialized training and makes them to formulate plans in identifying the training methods that suits to the individual employee capabilities
Pangs of Widowhood in Bapsi Sidhwa’s Novel Water
Authors:   Assistant Professor Department of English, Govt. T. C. L. P.G. College Janjgir (C.G.), Pandey Shalini
Published: February 2022

Since the dawn of time, gender inequity and sex discrimination have been the result of the human mentality. Internationally acclaimed author Bapsi Sidhwa has contributed significantly to the field of feminist fiction. Her magnificent novels are a mix of conflict and beliefs, sensibility and dignity, all of which are rooted in the Indian Subcontinent's historical, political, and socio-cultural context. Bapsi Sidhwa’s novel Water, set against the backdrop of Indian Freedom Movement, questions the orthodox religious traditions and the repressive restraints imposed on Hindu widows, pushing the bounds of India's male-dominated cultural narratives beyond patriarchal predicaments. She exposes the centuries-old practices that oppress women though her internationally acclaimed novels. The novel Water’s theme is contentious and complicated. It is about the plight of widows in India in 1930s. Water exposes traditional intrinsic indifference, fatalism, and orthodox conventions and injustice to women.
Geodesic locally starshaped G-invex sets and geodesic semilocal preinvex functions
Authors:   Department of Mathematics CSJM University Campus, Kanpur, U.P., India, Porwal Sandeep Kumar
Published: February 2022

In this paper, we introduce a new class of sets and functions, namely geodesic locally starshaped G-invex sets and geodesic semilocal preinvex functions on Riemannian manifolds. We study the properties of these classes of sets and functions and derive certain characterizations. The results of the paper extend and unify several known results from literature to a more general class of functions as well as in more general space setting
The use of various household wastes in the synthesis of melanin by Aureobasidium pullulans
Authors: MÜJDECİ Gamze Nur
Published: February 2022

It is known that food wastes occur in the entire food chain from farm to fork and pose a major problem worldwide. In Turkey, approximately 45 thousand tons of onion peel and 550 thousand tons of bread emerge as waste. On the other hand, the wastes of potato, apple, and pear in the field are approximately 455 thousand, 122 thousand, and 27 thousand tons per year, respectively. It is also known that the annual total kitchen waste generated only in Ankara is approximately 5.35 megatons. It is also obvious that traditional waste disposal methods cause environmental, economic, and social problems, and therefore, the conversion of food waste into biotechnological products with high added value is more sustainable, oriented to meet global needs, and is profitable. In this study, the potential use of onion, potato, apple, pear, and carrot peels, and bread residues for the production of melanin, a high-value-added pigment, by fermentation was investigated. In the fermentation studies, a native strain Aureobasidium pullulans AZ-6 and A. pullulans NBRC 100716 strain were used separately as inoculum. The highest total melanin production (3.71 g/L) from the food wastes in the study was achieved by A. pullulans NBRC 100716 with carrot peel extract, and a similar result (3.28 g/L) was obtained with apple peel extract. This study revealed that carrot and apple peels can be important substrate sources for melanin production.
Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes
Authors: Saare Liisa , Peet Aleksandr , Tillmann Vallo
Published: February 2022

The incidence of type 1 diabetes (T1D) is increasing throughout the world. This trend may be explained by the accelerator hypothesis. Our study investigated growth, its biochemical markers, and their associations with the development of diabetes-associated autoantibodies (DAAB) in 219 children with genetic risk for T1D. Subjects were divided into risk groups based on their human leukocyte antigen genotype. Children in the moderate- to high-risk group were significantly taller when corrected to mid-parental height and had a lower insulin-like growth factor 1 (IGF-1)/IGF-1 binding protein (IGFBP-3) molar ratio than those in the low-risk group (corrected height standard deviation score 0.22±0.93 vs. –0.04±0.84, P<0.05; molar ratio 0.199±0.035 vs. 0.211+0.039, P<0.05). Children with DAAB tended to be taller and to have a higher body mass index than those with no DAAB. Our results suggest that the accelerator hypothesis explaining the increasing incidence of T1D may not solely be dependent on environmental factors, but could be partially genetically determined.
EW-7197 Attenuates the Progression of Diabetic Nephropathy in db/db Mice through Suppression of Fibrogenesis and Inflammation
Authors: Ha Kyung Bong , Sangartit Weerapon , Jeong Ah Reum , Lee Eun Soo , Kim Hong Min , Shim Soyeon , Kukongviriyapan Upa , Kim Dae-Kee , Lee Eun Young , Chung Choon Hee
Published: February 2022

Background: Diabetic nephropathy (DN) is characterized by albuminuria and accumulation of extracellular matrix (ECM) in kidney. Transforming growth factor-β (TGF-β) plays a central role in promoting ECM accumulation. We aimed to examine the effects of EW-7197, an inhibitor of TGF-β type 1 receptor kinase (ALK5), in retarding the progression of DN, both in vivo, using a diabetic mouse model (db/db mice), and in vitro, in podocytes and mesangial cells.Methods: In vivo study: 8-week-old db/db mice were orally administered EW-7197 at a dose of 5 or 20 mg/kg/day for 10 weeks. Metabolic parameters and renal function were monitored. Glomerular histomorphology and renal protein expression were evaluated by histochemical staining and Western blot analyses, respectively. In vitro study: DN was induced by high glucose (30 mM) in podocytes and TGF-β (2 ng/mL) in mesangial cells. Cells were treated with EW-7197 (500 nM) for 24 hours and the mechanism associated with the attenuation of DN was investigated.Results: Enhanced albuminuria and glomerular morphohistological changes were observed in db/db compared to that of the nondiabetic (db/m) mice. These alterations were associated with the activation of the TGF-β signaling pathway. Treatment with EW-7197 significantly inhibited TGF-β signaling, inflammation, apoptosis, reactive oxygen species, and endoplasmic reticulum stress in diabetic mice and renal cells.Conclusion: EW-7197 exhibits renoprotective effect in DN. EW-7197 alleviates renal fibrosis and inflammation in diabetes by inhibiting downstream TGF-β signaling, thereby retarding the progression of DN. Our study supports EW-7197 as a therapeutically beneficial compound to treat DN.
Development of Metabolic Synthetic Lethality and Its Implications for Thyroid Cancer
Authors: Ju Sang-Hyeon , Lee Seong Eun , Kang Yea Eun , Shong Minho
Published: February 2022

Cancer therapies targeting genetic alterations are a topic of great interest in the field of thyroid cancer, which frequently harbors mutations in the RAS, RAF, and RET genes. Unfortunately, U.S. Food and Drug Administration-approved BRAF inhibitors have relatively low therapeutic efficacy against BRAF-mutant thyroid cancer; in addition, the cancer often acquires drug resistance, which prevents effective treatment. Recent advances in genomics and transcriptomics are leading to a more complete picture of the range of mutations, both driver and messenger, present in thyroid cancer. Furthermore, our understanding of cancer suggests that oncogenic mutations drive tumorigenesis and induce rewiring of cancer cell metabolism, which promotes survival of mutated cells. Synthetic lethality (SL) is a method of neutralizing mutated genes that were previously considered untargetable by traditional genotype-targeted treatments. Because these metabolic events are specific to cancer cells, we have the opportunity to develop new therapies that target tumor cells specifically without affecting healthy tissue. Here, we describe developments in metabolism-based cancer therapy, focusing on the concept of metabolic SL in thyroid cancer. Finally, we discuss the essential implications of metabolic reprogramming and its role in the future direction of SL for thyroid cancer.
CULTURAL PROBES METHOD IN DESIGN RESEARCH: CREATIVITY IN SKETCHES
Authors: Černevičiūtė Jūratė , Liebutė Lina
Published: February 2022

Despite the abundance of methods and models, the design research is still often entangled in concepts irrelevant to design practice. This paper rethinks the discourse of design research and the evolving role of a designer. The most important attempts to build a design as an academic discipline are mentioned, along with research communities that are operating in the field of design. Art-and-design-based approach in design research in Donald Schön’s works on architecture and design practice, rises the importance of sketches in the creative idea generation. Implementing sketching techniques into the cultural probes, as one of an art-and-design-based research method, opens up ways to innovative design solutions. This paper discusses the relationship between the method and sketching in the context of the case study “When Nobody Sees”. Sketching is discussed as an art-based tool for problem-setting.
Convective Boundary Mixing Processes
Authors: Anders Evan H. , Jermyn Adam S. , Lecoanet Daniel , Fuentes J. R. , Korre Lydia , Brown Benjamin P. , Oishi Jeffrey S.
Published: February 2022

Convective motions extend beyond the nominal boundaries of a convection zone. These motions mix fluid through multiple mechanisms collectively called “convective boundary mixing.” In this note, we discuss three distinct fluid dynamical processes: convective overshoot, entrainment, and penetrative convection. We describe the structure of a convective boundary that these processes create. To resolve discrepancies between models and observations, the stellar astrophysics community should distinguish between these processes and parameterize each of them separately in 1D evolutionary models.
Experience of Mother on Caring of Children with Low Birth Weight in an Urban Setting, Indonesia: A Descriptive Phenomenological Study
Authors: Zubaidah Zubaidah , Rustina Yeni , Nurhaeni Nani , Hastono Sutanto Priyo
Published: February 2022

BACKGROUND: Low birth weight is a major public health issue; it causes higher mortality rate among neonatal. Therefore, it is essential for caregivers to know how to save the baby’s life with evidence-based practices at home. The previous studies found that low birth weight mothers had poor awareness caring their babies at home care adequately.

AIM: The objective of the study was to explore experience of mothers on caring for children with low birth weight from an urban setting in a low-middle-income country.

METHODS: This was a descriptive phenomenological approach. This study was conducted in a rural setting in the Semarang region of Indonesia. Ten mothers whose babies with low birth weight had been discharged from the perinatology care unit in a secondary level hospital and resided in Semarang were interviewed in their homes using a semi-structured interview guide. Data were audiotaped, transcribed verbatim, and analyzed inductively by content analysis.

RESULTS: Twenty mothers aged 20–37 years were interviewed. Most of the babies were moderate to late preterm, and the gestational age at delivery ranged between 33 and 38 weeks gestation, and the birth weights of the babies ranged between 1.4 and 2 kg. Five major themes emerged, which included the psychological response of mothers, sharing information related to the care procedure, breastfeeding, social support, and health-seeking behavior.

CONCLUSIONS: The findings indicate that home management of low birth weight babies poses multiple needs and is associated with poor quality of care. Hence, extensive education and identification of other social support systems are needed to augment facility-based care for mothers and their babies.
Online Learning Methods during COVID-19 Pandemic: On an Indonesian Nursing Student Experience
Authors: Mamnuah Mamnuah , Wantonoro Wantonoro
Published: February 2022

BACKGROUND: The policy of limiting community activities during the COVID-19 pandemic affects the learning process. The expectation of the online learning methods is a stressor for the students. For this reason, it is necessary to explore the experiences of the students during online learning.

AIM: The purpose of this study was to explore the experiences, especially hopes and needs of the students, while undergoing online learning during the COVID-19 pandemic.

METHODS: This study applied a qualitative approach with a phenomenological design. The participants involved were six health students from the Faculty of Health Sciences in Yogyakarta, Indonesia. They were recruited using a purposive sampling technique. Data were collected through online interview. The data were then analyzed using the Colaizzi technique.

RESULTS: The results illustrated that there are two themes of the students’ expectations during the learning, including the expectations of the learning process and the expectations of the lecturers. There are two themes for the students’ needs during the online learning, namely, family support and internet network support. The students expect that the learning process is carried out with a combination of learning methods and the lecturers to understand the problems faced by students.

CONCLUSION: The students need the support of a good internet network and family support so that they can participate in the online learning well.
Ventriculoperitoneal Shunt Infection: A Study about Age as a Risk Factor in Hydrocephalus Pediatrics
Authors: Bastian Reza Akbar , Pramusinto Handoyo , Basuki Endro , Marianne Marianne
Published: February 2022

BACKGROUND: Shunt infection is one of the dreaded and serious complications following ventriculoperitoneal shunt (VP shunt) insertion, especially in a pediatric population. Numerous risk factors have been identified, particularly in developing countries, indicating that age may play an essential element in the pathogenesis of shunt infection, typically in patients <1-year-old. However, a few research demonstrate the inverse result.

AIM: The purpose of this was to determine the relationship between age and shunt infection so that it can be taken into consideration when performing VP shunt insertion.

METHODS: From January 2017 to December 2019, 98 pediatric patients with hydrocephalus who underwent VP shunt insertion were retrospectively reviewed to determine the relationship between age and shunt infection. We evaluated the microbiology results and management of shunt infection in patients with shunt infection.

RESULTS: Fifteen (15.15%) of 98 patients developed shunt infection. Patients aged >3–6 months had a significantly increased risk of shunt infection (p = 0.04; RR = 4.15; CI 95% = 1.19–14.45). Staphylococcus aureus was the most frequently encountered pathogen in pediatric patients with shunt infection (53.3%), and the most common management for shunt infection was complete removal of the shunt and systemic antibiotics followed by re-insertion of the shunt after the cerebrospinal fluid was sterile (46.6%).

CONCLUSION: We conclude that age, especially those aged >3–6 months, has a significantly higher risk of shunt infection in pediatric patients.
Species conservation profiles of cave-adapted terrestrial isopods from Portugal
Authors: Reboleira Ana Sofia , Eusébio Rita , Taiti Stefano
Published: February 2022

Terrestrial isopods (Oniscidea) are the most diverse group of troglobionts in caves of continental Portugal. They occur in all karst regions of Portugal, play a major role in decomposition of organic matter in caves and may act as umbrella species for the conservation of all other cave-adapted invertebrates.

We present the IUCN Red List profiles for the cave-adapted terrestrial isopods from continental Portugal, based on recent distribution data from caves.
An unexpected new genus of panurgine bees (Hymenoptera, Andrenidae) from Europe discovered after phylogenomic analysis
Authors: Wood Thomas J. , Patiny Sébastien , Bossert Silas
Published: February 2022

Establishing a higher classification of bees based on morphology alone can fail to capture evolutionary relationships when morphological characters either vary very little between distantly related groups, or conversely vary greatly between closely related species. This problem is well represented in the subfamily Panurginae, for which a recent global revision based on phylogenomic data unexpectedly revealed that two Old World species previously placed inCamptopoeumSpinola andFlavipanurgusWarncke, are in fact most closely related to each other, and together form a sister group relationship to the remainingFlavipanurgusandPanurgusPanzer combined. To rectify this situation, we here establish an expanded phylogenomic data set of Old World Panurgini and re-assess generic and subgeneric concepts for the tribe. To solve the paraphyly ofCamptopoeumandFlavipanurgus, we establish the new genusHalopanurgusgen. nov.containing the speciesH. baldocki(Wood & Cross),comb. nov.andH. fuzetus(Patiny),comb. nov., both of which are restricted to coastal sands, saltmarshes, and inland saline lagoons in the extreme south of Portugal and south-west of Spain. Re-evaluation of four recently used subgenera inPanurgusstrongly supports a simplified classification of two subgenera;PachycephalopanurgusPatiny,stat. rev.includingMicropanurgusPatinysyn. nov., andPanurguss. str. includingEuryvalvusPatiny.Pachycephalopanurgusspecies seem to be oligoleges of Asteroideae (Asteraceae), whereasPanurguss. str. may be oligoleges of Cichorieae (Asteraceae). Our findings reinforce the challenges of establishing a phylogenetically sound classification of Panurginae using morphology alone and illustrate that even in well-studied regions like Europe unrecognised genera can persist in underexplored corners of the continent.
Bohayella rodrigodiazi sp. nov.: a new species from Ecuador with an updated key to the New World species of Bohayella Belokobylskij (Hymenoptera, Braconidae, Cardiochilinae)
Authors: Kang Ilgoo
Published: February 2022

The New World species of Bohayella Belokobylskij, 1987 are revised based on morphological data, and a new species of the genus from Ecuador is described: Bohayella rodrigodiazi Kang, sp. nov. This work includes an updated identification key to species of Bohayella in the New World along with images of diagnostic characters. The number of recorded Bohayella species in the New World is increased from two to three.
Annual dynamics of eukaryotic and bacterial communities revealed by 18S and 16S rRNA metabarcoding in the coastal ecosystem of Sagami Bay, Japan
Authors: Sogawa Sayaka , Tsuchiya Kenji , Nagai Satoshi , Shimode Shinji , Kuwahara Victor S.
Published: February 2022

Sagami Bay, Japan is influenced by both the warm Kuroshio Current and the cold Oyashio Current and rich nutrients are supplied from multiple river sources and the deep-sea, forming a dynamic ecosystem. The aim of the present study was to investigate eukaryotic and bacterial communities in the coastal waters of Sagami Bay, using 16S rRNA and 18S rRNA sequencing and to assess the seasonal and vertical dynamics in relation to physicochemical and biological conditions. Eukaryotic and bacterial communities showed synchronous seasonal and vertical changes along with environmental variability. Diversity of plankton community suspended in the surface was lower than those at the subsurface layers in both the eukaryotes and bacteria communities; however, community diversity showed different characteristics in the subsurface where the eukaryotic community at the deeper layer (100 m) was as low as the surface and highest in intermediate depth layers (10–50 m), while that of bacterial community was highest in the deeper layer (100 m). The annual variability of the coastal microbial communities was driven, not only by the seasonal changes of abiotic and biotic factors and short-term rapid changes by river water inflow and phytoplankton blooms, but also largely influenced by deep-seawater upwellings due to the unique seafloor topography.
À la charnière de l’administration et des professions
Authors: Gay Renaud
Published: February 2022

L’article analyse la conception et les transformations depuis les années 1960 d’une ingénierie financière qui est orientée vers la maîtrise des dépenses hospitalières. Il s’intéresse aux relations d’alliance qui portent ces instruments entre des médecins hospitaliers, des directeurs d’hôpital et des cadres de l’administration sanitaire. Il montre ainsi que ces instruments sont constitués à la charnière des écologies étatique et professionnelle au sein desquelles ils sont investis de différentes significations et appuient des stratégies de revendication ou de protection territoriales. Ces alliances sont appréhendées en distinguant trois séquences historiques qui analysent leur évolution et les changements d’instrument dont elles sont porteuses, d’un prix de journée sophistiqué jusqu’à l’adoption d’une tarification à l’activité.
Une mobilisation réformatrice ? Sauvons la recherche et la genèse des réformes de politique scientifique en France
Authors: Gozlan Clémentine
Published: February 2022

En réaction aux coupes massives dans le budget de la recherche française au début du XXI e  siècle s’est formé le mouvement « Sauvons la recherche » (SLR). Il émerge en 2004 en dehors des structures syndicales suite à la mobilisation de biologistes de renom qui se questionnent sur l’avenir de leur métier et sur les manières de défendre les intérêts de la science. En articulant sociologie des professions, sociologie des mobilisations et sociologie de l’action publique, cet article décrypte le rôle singulier qu’a joué un mouvement social de chercheurs dans la mise sur agenda des réformes de la recherche au début du XXI e  siècle. Fondé sur la collecte d’archives inédites et plus de trente entretiens approfondis avec les scientifiques qui ont participé au mouvement dès son origine, l’article retrace comment SLR a d’abord construit un rapport d’opposition frontale au gouvernement, puis en est venu à participer au Comité d’initiative et de proposition (CIP), qui organise le travail réformateur des États généraux de la recherche en 2004. Il montre que la constitution de cette « charnière », c’est-à-dire au sens d’Andrew Abbott cet espace d’intermédiation entre gouvernement et collectif professionnel, est le produit d’une histoire conflictuelle, de débats et jeux sur les frontières de la profession et sur son rapport au politique. Entre mobilisation protestataire et travail réformateur, le cas dévoile une forme singulière de l’association des professionnels au gouvernement de leur secteur.
La santé au travail au secours de l’action syndicale ? Retour sur la « sanitarisation » d’un répertoire d’action militant
Authors: Ponge Rémy
Published: February 2022

De nombreuses explications ont été avancées pour rendre compte de la visibilité croissante des souffrances psychiques du travail (stress, burn-out, risques psychosociaux, etc.) dans l’espace public : « psychologisation » du social, recomposition des maux du travail, construction d’un problème public par des acteurs mobilisés, etc. Cet article s’intéresse au rôle des organisations syndicales et explore la piste d’une « sanitarisation » de l’action syndicale. Il interroge ainsi ce que la place croissante du thème des souffrances du travail dans le discours et les pratiques des organisations syndicales nous dit des transformations contemporaines du syndicalisme et de son rôle dans la politisation des enjeux du monde du travail. Articulant matériaux d’archives et entretiens, nous analysons les pratiques des acteurs en charge des questions de santé au travail au sein des directions des deux principales centrales syndicales françaises, la CFDT et la CGT, des années 1990 à aujourd’hui. Nous montrons que s’il s’est d’abord agi pour les directions syndicales, particulièrement la CGT, d’apporter une réponse à un problème social fortement publicisé, la mise à l’agenda des souffrances au travail est étroitement liée aux rapprochements entre des acteurs des champs syndical et scientifique d’une part et, d’autre part, aux difficultés croissantes des syndicalistes face aux directions d’entreprise. Dans un contexte de faible syndicalisation et de difficile recours aux outils de l’action collective (grèves, arrêts de travail), les directions syndicales tentent, à partir des enjeux de santé au travail, d’aider leurs militant·es à reprendre la main sur des questions classiques touchant au partage du pouvoir dans l’entreprise. Cette dynamique de sanitarisation n’est cependant pas univoque et reste fortement dépendante des enjeux propres au champ syndical et des acteurs qui y interviennent.
Nonlinear wave train in an inhomogeneous medium with the fractional theory in a plane self-focusing
Authors: Asjad Muhammad Imran ,   Department of Mathematics, University of Management and Technology, Lahore, Pakistan, Faridi Waqas Ali , Jhangeer Adil , Aleem Maryam , Yusuf Abdullahi , Alshomrani Ali S. , Baleanu Dumitru ,   Department of Mathematics, Namal Institute, Talagang Road, Mianwali 42250, Pakistan,   Department of Computer Engineering, Biruni University, Istanbul, Turkey,   Department of Mathematics, Near East University TRNC, Mersin 10, Turkey,   Department of Mathematics, King Abdul Aziz University, Jeddah, Saudi Arabia,   Department of Mathematics, Cankaya University, Ankara, Turkey,   Institute of Space Sciences, Magurele, Bucharest, Romania,   Department of Medical Research, China Medical University, Taichung, Taiwan
Published: February 2022

The aim of study is to investigate the Hirota equation which has a significant role in applied sciences, like maritime, coastal engineering, ocean, and the main source of the environmental action due to energy transportation on floating anatomical structures. The classical Hirota model has transformed into a fractional Hirota governing equation by using the space-time fractional Riemann-Liouville, time fractional Atangana-Baleanu and space-time fractional $ \beta $ differential operators. The most generalized new extended direct algebraic technique is applied to obtain the solitonic patterns. The utilized scheme provided a generalized class of analytical solutions, which is presented by the trigonometric, rational, exponential and hyperbolic functions. The analytical solutions which cover almost all types of soliton are obtained with Riemann-Liouville, Atangana-Baleanu and $ \beta $ fractional operator. The influence of the fractional-order parameter on the acquired solitary wave solutions is graphically studied. The two and three-dimensional graphical comparison between Riemann-Liouville, Atangana-Baleanu and $ \beta $-fractional derivatives for the solutions of the Hirota equation is displayed by considering suitable involved parametric values with the aid of Mathematica.
University Students’ Perceptions on the Use of Google Translate: Problems and Solutions
Authors: Pham Anh Tuan , Nguyen Y Ngoc Nhu , Tran Loi Thang , Huynh Khang Duy , Le Ngan Thi Kim , Huynh Phuc Trong
Published: February 2022

Machine learning has globally become a trend in most educational settings. This study aims to explore students’ perceptions when using Google Translate (GT) to support their learning as well as their problems and solutions from GT. With the participation of 250 university students at a private educational institution, a 5-point Likert-scale questionnaire and a semi-structured interview were employed to examine how students perceived the use of GT in their learning process. The findings revealed that practically students had positive perceptions on GT’s use in learning. Several major problems were recorded when they used GT, and some recommended solutions were also considered for improvement. Specifically, students utilized GT as a learning tool, particularly for language study, because of its useful features such as multi-language translation, time saving, ease of use, and improving pronunciation. Although Google Translate has a number of advantages for students, several problems such as erroneous grammar and semantics on a frequent basis have led to misunderstanding of original words. As a result, students discovered that they needed to deal with these problems by double checking the results in a dictionary or other translation programs, as well as the help from a peer or supervisor. It is suggested that GT is a helpful machine translator, but students are encouraged to know how to make some judgement on its results for a better translation version.
A introdução da explicação científica dos acontecimentos ambientais: focos de disputa entre o Setor Elétrico e os movimentos de Atingidos – Tucuruí, Pará
Authors: Weitzman Rodica
Published: February 2022

Este artigo destaca as mudanças nas ferramentas de luta empregadas pelos movimentos de atingidos a partir do agravamento dos impactos ambientais, tendo como base as inflexões dentro das cronologias apresentadas nos diversos registros. O recorte metodológico deste estudo é a construção de uma memória do vivido com base na análise de um acervo arquivístico que é gerado dentro de um processo de interação social. Os conjuntos documentais nos fornecem pistas para demonstrar a evolução das configurações organizacionais, desde as expressões embrionárias de resistência dos “desapropriados”, “expropriados” e “atingidos”, durante as fases iniciais de intervenção da empresa Eletronorte na região de Tucuruí, Pará, até sua adesão gradativa a um movimento abrangente e diversificado que tem como ápice a consolidação de repertórios de ação política face às alterações drásticas no quadro socioambiental. No cerne de conflitos entre aqueles que coordenam as intervenções e aqueles que são sujeitados/as aos efeitos visíveis e invisíveis deste modus operandi do mundo empresarial, a opção pela explicação científica dos efeitos ambientais por meio do desenvolvimento de pesquisas e da documentação cuidadosa destes dados empíricos se torna uma ferramenta potente de contestação das posturas institucionais da Eletronorte e dos seus aliados estratégicos.
Agroecología o Agricultura más que humana?: La coordinación con las plantas como técnica agrícola
Authors: Schiavoni Gabriela
Published: February 2022

Focalizando en la agricultura de roza y quema, propia de los grupos indígenas y campesinos de las regiones tropicales y subtropicales del globo, este artículo describe diversas formas del vínculo entre los hombres y las plantas. La noción de agricultura más que humana comprende los aspectos no intencionales de la domesticación, haciendo recaer la operación técnica en un organismo mixto humano-vegetal. La reflexión está arraigada en la provincia de Misiones (nordeste de la Argentina) y su región circundante (Paraguay y sur de Brasil). Recuperando elementos de la agricultura guaraní, tales como el consorciamiento de cultivos, establecemos un puente con la agroecología actual.