bluuebunny/crossref_metadata_2025 huggingface dataset:
Survival Rates of Hepatocellular Carcinoma BCLC-B Patients who underwent Hepatic Resection at UP-PGH: A 10-Year Single-Center Experience
Authors: Bacaro Teresa Mae , Ang Dante , Berberabe Apolinario Ericson
Published: January 2025

Rationale/Objective:
Hepatic Resection (HR) has emerged as a potentially curative treatment for HCC, particularly in Barcelona Clinic Liver Cancer – B (BCLC-B) patients, even though Transarterial Chemoembolization (TACE) is the standard of care according to the BCLC staging system. This study aimed to investigate the characteristics, survival rates and outcomes of patients who underwent HR for HCC BCLC-B at a single center over a 10-year period.

Methods:
Patients who were diagnosed HCC BCLC-B and had undergone HR from January 2011 to December 2021 were analyzed. Only complete records with long-term follow-up were included in the study. The authors described patient characteristics, calculated overall survival rates, and assessed associations between patient, disease factors, and survival.

Results:
Of 344 patients who underwent HR, 20 of them had complete records with long-term follow-up. This cohort had a median age of 57, predominantly male (70%), exhibiting a median alpha-fetoprotein (AFP) level of 230.5 ng/mL and an average of 4 nodules. Lymphovascular invasion was evident in 65%, with 85% displaying negative primary tumor margins. Major hepatectomy was the primary procedure (50%), followed by bisegmentectomy (40%) and trisegmentectomy (10%). The 1, 2 and 3-year survival rates post-hepatic resection (HR) for HCC BCLC-B stood at 65%, 35% and 25% respectively.

Conclusion:
The study shows that the institution’s treatment approach for BCLC-B HCC patients achieved acceptable 3-year survival rates, and the median overall survival rate observed are comparable with global data. This study highlights hepatic resection as a potential curative option for BCLC-B HCC patients.
Analyzing the native characteristics of positive-oriented leadership for managers department heads of public universities in Tehran
Authors: chavoshi zahra , Navehebrahim Abolrahim , Abdollahi Bijan , Zinabedi Hasanreza
Published: January 2025

The purpose of this article is to analyze the components of positive leadership for department heads. By use of qualitative approach, purposeful and snowball sampling method was used to select people for research interviews. Interviews reached to saturation by 15 samples. Interviews were classified by use of three phases of qualitative coding system, namely open, axial and selective coding. Samples were selected from among the faculty members of Kharazmi University, Tehran University, Allameh Tabatabai University, Farhangian University, Higher Education Research and Planning Institute. The research showed 131 open components for positive leadership of department heads. It can be classified into, 3 selective dimensions, and, 12 core dimensions that include personality characteristics (individual characteristics, social characteristics), professional ethics (research ethics, educational ethics, managerial ethics), leadership and management skills (transformational, politician, improving quality and increasing efficiency, human resource management, communication skills, teamwork, international relations and marketing).
BUILDING A DYNAMIC CROPPING TREND VISUALIZATION SOFTWARE TO ASSESS FARMING PROGRESSIVENESS
Authors: MANNAN MUHAMMAD ABDUL , AL MAMUN MD. MUNTASEER , LEMON MD. NAZIUR ISLAM , SIMA SHAMMI AKTER , RAHMAN MD. ASHIKUR , TASNIM MAHRUPA
Published: January 2025

This thesis presents a comprehensive study that unfolds in two key dimensions. Firstly, a novel cropping trend visualization software was developed, aiming to provide a dynamic and insightful tool for assessing farming progressiveness. This software, a product of meticulous design and implementation, serves as an innovative instrument for visualizing and analyzing cropping trends in agriculture. In the second part of the study, the software was utilized to gather descriptive and inferential statistical data from a sample of 111 farmers. The data analysis reveals noteworthy correlations between specific agricultural practices and farming progressiveness. Key findings indicate significant positive associations between technology adoption, climate adaptation, crop variety diversity, and environmentally sustainable practices with higher levels of farming progressiveness. While certain trends exhibit statistical significance, caution is advised in drawing robust conclusions for factors with limited statistical support. These empirical insights provide a valuable foundation for policymakers, agricultural extension services, and stakeholders to strategically promote practices that enhance the overall progressiveness of farmers. The dual contribution of the developed software and the derived insights from its application underscores the significance of integrating technology in advancing sustainable and progressive agricultural practices.
Analysis Of The Determinants Of Electrical Energy Consumption In The Period Of 2017 – 2023 (Case Study Of Provinces In Indonesia)
Authors: Siti Naeni Nur Khaeni  , Hastarini Dwi Atmanti
Published: January 2025

The purpose of this study is to examine the variables influencing Indonesia's electrical energy consumption from 2017 to 2023. Utilising secondary data from Central Bureau of Statistics of Indonesia and State Electricity Company (PLN) for the years 2017– 2023, quantitative research using a regression analysis approach is the study methodology employed. The population, income per capita, information technology development index, and human development index are the independent variables in this study. The population, human development index, and per capita income all had a significant impact on the amount of electrical energy used, according to the findings. In the meanwhile, there is a slight but negative impact from the information technology development index. Together, the independent factors can account for 88.6% of the fluctuation in Indonesia's electrical energy usage. According to the study's findings, increasing electrical energy.
De la Automatización a la Autonomía: Consecuencias de la Inteligencia Artificial en la Cuarta Revolución Industrial
Authors: Guerschberg Leandro
Published: January 2025

The Fourth Industrial Revolution, led by Artificial Intelligence (AI), is reshaping the labor market globally. This article reviews the literature on the implications of AI proliferation in the labor context, highlighting how the transition from automation to autonomy affects both job creation and destruction. Sectors such as manufacturing, healthcare, and transportation experience gains in productivity and efficiency, yet also face risks of technological unemployment and skills mismatch. The PRISMA methodology allows us to identify studies that analyze these dual effects, exploring everything from the displacement of routine jobs to the creation of new job opportunities in high-skill areas. The findings underline that, while AI has the potential to generate economic growth and new job profiles, it also calls for job retraining policies and adaptive education. This study provides a critical view on the future of work in the AI era, highlighting the importance of a regulatory framework that protects workers and fosters a balanced technological integration across sectors.
El catecismo escolar y las lenguas en contacto: el Ledesma en catalán
Authors: Calafat Vila Rosa Maria
Published: January 2025

Este artículo pretende analizar, especialmente en el contexto de la Iglesia mallorquina, los efectos de la imbricación entre catalán y castellano en los catecismos populares, desde el Renacimiento (el español como lengua de élite) hasta la Ilustración (imposición de la lengua del Estado). A partir de la disciplina sociolingüística, se abordan las ediciones del catecismo de Ledesma en catalán que se imprimieron en Cataluña y en Mallorca durante los siglos XVII y XVIII, al objeto de medir hasta qué punto el contacto lingüístico de dos lenguas vivas (catalán y castellano), con la presencia del latín como lengua referencial de la Iglesia, se evidencia en estas ediciones. Se concluye que las ediciones mallorquinas incorporan coplas y otros recursos populares en castellano, reservando un espacio limitado al latín. Por el contrario, los catecismos publicados en Cataluña hacen un uso más extensivo del latín y prescinden del castellano.
Tumor Suppressor microRNAs as Potential Treatment Therapeutics for Advanced Medulloblastoma
Authors: Luu Chanlee , Salyer Gabriel , Gerace Linda , Abdul-Kader Maryam , Azizi Ava , Puerto Alan Mariño del , Thakkar Param , Chen Yvonne , Ivory Jill , Amrick Rebecca , Novajas Martina , Schnieder Evan , Adams Brian D.
Published: January 2025

Medulloblastoma (MB) is one of the most prevalent forms of malignant brain cancer observed within pediatric patients and is particularly difficult to diagnose and treat due to the anatomical localization of tumors near the brainstem. Currently, there are four molecular classifications of MBL: WNT, SHH, Group 3, and Group 4 tumor subgroups. Wingless-type (WNT) mutant tumors are the least common, often caused by mutations in the CTNNB1 gene that plays a crucial role in the wingless cell signaling pathway, yet associates with the best prognosis as compared to all other MBL subtypes. Sonic hedgehog (SHH) mutant tumors arise due to continued release of Shh from purkinje cells, and an uninhibited proliferation response by granular neuronal precursors (GNPs). Group 3 and 4 MBL subgroups are still a molecularly heterogeneous class of tumors, with Group 3 MBL being highly associated with metastasis upon diagnosis, and more prevalently characterized by MYC amplification and activation. Group 4 MBL tumors comprise approximately 40% of all MBL, and remain remarkably heterogeneous with respect to somatic mutations of genes such as KDM6A, OTX2, ZMYM3, with an approximate 80% of tumors harboring chromosome 17 copy number alterations. While a majority of MBL cases cannot be linked to a single protein coding gene alteration, the role of non-coding RNAs, such as miRNAs, seems quite promising as a genetic marker to further sub-categorize MBL at the molecular level. Furthermore, miRNA-based therapy is proving to be a promising treatment to curb the growth of a number of cancer types within the clinic, with particular miRNAs under investigation including miR-34a, miR-211, and miR-584-5p. These miRNAs are known to induce cell cycle arrest in mouse models and demonstrate anti-tumorigenic properties in vitro, meriting further investigation of miRNA-based clinical trials for pediatric MBL patients.
Therapeutic Efficacy of Platinum Based Medicines Combined with Various Nanoparticles in the Treatment of Colorectal Cancer: A Comprehensive Review
Authors: Meng Xin
Published: January 2025

Colorectal cancer continues to be a major cancer that affects patients in terms of morbidity and mortality. Chemotherapy using cisplatin, oxaliplatin among others based with platinum have remained the mainstay in the treatment of diverse cancer including the colorectal cancer. However, these treatments are not very effective because of drug resistance, systemic toxicity, and low selectivity. The advances in nanotechnology in the past years presented nanoparticles as potential drug delivery systems which provide sharp targeting, minimum toxicity and better therapeutic efficacy. This review aims at discussing how platinum-based drugs can complement nanoparticles, for example liposomes, dendrimers and gold nanoparticles for colorectal cancer treatment. This review, discussed how nanoparticles can improve the effectiveness of platinum drugs; present sample findings from preclinical and clinical research; and analyze the perspectives of such combinations for the current therapy shortcomings overcoming. Furthermore, authors have looked at the prospects and challenges of this relatively young branch of research and discuss the opportunities that can lie in personalized medicine concepts, as well as the further evolution of nanoparticles. The purpose of this review is to enhance the current knowledge of platinum-nanoparticle combinations and to outline its future directions for colorectal cancer treatment.
Decrypting the Crosstalk Mechanisms Between cGAS-STING and TBK1 Signaling Pathways in Cancer Immunotherapy: A Comprehensive Review
Authors: Gayen Sakuntala , Parui Ankita , Arshad Amima , Roy Nipa , Sarkar Asmita Nag , Roy Souvik
Published: January 2025

In the tumor microenvironment, the cytosolic DNA sensing, cyclic GMP-AMP synthase- stimulator of interferon genes (cGAS-STING) pathway is a crucial regulator of immune response. The cGAS of innate immunity recognizes cytoplasmic DNA by catalyzing cyclic GMP-AMP (cGAMP), which subsequently activates the STING pathway. STING activation leads to the phosphorylation of TANK-binding kinase 1 (TBK1) and recruitment of key transcription factor IRF3, notably to initiate the production of pro-inflammatory cytokines and Type I IFNs. This cascade enhances antigen presentation and primes cytotoxic T-cells, leading to the induction of anti-tumor immune response. Specific crosstalk mechanisms, such as TBK1-mediated negative feedback to limit excessive STING activation or its cooperation with NF-κB to balance immune responses, play pivotal roles in shaping tumor immunity. Harnessing this axis in cancer immunotherapy has emerged as a promising strategy, offering synergy with immune checkpoint blockade and CAR T-cells therapy. Fine-tuning activation of this pathway is crucial for balanced immune responses, making cGAS-STING/TBK1 signal transduction a major target for novel cancer therapies. This review elucidates the intricate crosstalk mechanisms of cGAS-STING and TBK1 signal transduction within tumor microenvironment. These may shed insight on cancer therapy options and their pivotal roles in modulating tumor immunity.
Biomechanically-informed emotion recognition algorithm of sports athletes based on deep neural network
Authors: Zhou Weiwei , Yang Zheng
Published: January 2025

The environment of sports competition is changing rapidly, and there is a certain relationship between athletes’ decision-making and executive functions and athletes’ emotions. Positive emotions can enhance reaction inhibition, while negative emotions will damage the inhibition function. Therefore, identifying the emotions of athletes in sports competitions can help coaches quickly grasp the emotional state of athletes, so as to make targeted decisions. With the advent of the era of big data and the continuous in-depth development of deep neural networks, the emergence of various networks and network models has not only made rational use of a large amount of data, but also promoted the continuous development of emotion recognition. This paper takes the research on the emotion recognition algorithm of sports athletes as the object, uses the faster CNN network to recognize the facial emotion, modifies the backbone network model and loss function parameters in the network, selects the best performing network through comparative experiments, and applies it to the research field of emotion recognition algorithm of sports athletes. While understanding the emotional state of athletes in sports competitions, it lays a solid foundation for the follow-up study of athletes’ emotional recognition algorithm in sports competitions. The main research contents of this paper are as follows: firstly, this paper selects data sets with different characteristics, classifies them according to the status of athletes in sports competitions, and labels the data sets. Secondly, Fast Region-based Convolutional Neural Networks (R-CNN) is used to train the labeled data set and obtain the model, and compare the accuracy in different model and loss function parameter conditions. Finally, according to the experimental comparison results, the network with the highest accuracy is selected and applied to the research of athletes’ emotion recognition algorithm in sports competitions.
The Affecting Mechanism of Fun of Learning Environment on Digital Literacy of High School Students Studying Japanese in Shandong Province, China
Authors: Wan Jiyou
Published: January 2025

Digital literacy is the main cause of enhancing students’ future academic performance and promoting their growth, and fun learning activities are associated with digital literacy. Therefore, using a sample of 1,036 high school students studying Japanese in 23 schools in Shandong Province, China, the relationship between fun of learning environment and digital literacy, as well as the facilitating role of inner peace state and motivational regulation strategies, were investigated. The results confirm, for the first time, that fun in the learning environment was positively related to digital literacy of high school students studying Japanese in Shandong Province, China. That inner peace state and motivational regulation strategies had a facilitating effect. This suggests that high school students studying Japanese need not only fun learning activities but also the connection between experienced peace states of mind and self-motivated control strategies to promote their digital literacy fully in Shandong Province, China.
构筑“二四五”心格局守护学生心理健康——以阜阳职业技术学院为例
Authors: Sun Qiang , Wang Jingbo , Liu Hongyu
Published: January 2025

新时代背景下，高校学生心理健康教育工作已成为学校育人体系的重要组成部分，各校都在努力构建符合自身实际的心理健康教育工作模式。本文以阜阳职业技术学院为例，总结近年来学院积极探索并完善形成的“二四五”心理健康教育工作机制，即“两个课堂”“四位一体”和“五育并举”工作格局，守护学生心理健康。通过提高学生的心理健康意识、加强心理健康教育课程的设置、增加心理健康服务资源等措施，促进学生全面健康成长，以期为其他高校的心理健康教育工作提供经验参考。
从适应到疏离：韩国留学生在华小城市的跨文化适应经历研究
Authors: Huai Yanxin
Published: January 2025

以一名韩国留学生为研究对象，采用质性研究中的深度访谈法，探讨了该留学生在中国东北小城市的跨文化适应经历。留学生在小城市的留学经历有三个显著特征，一是因方言引起的语言障碍；二是对教育质量的高期望未能得到满足；三是由于地理位置较为偏远引起的出行不便。基于Lysgaard的跨文化适应U型曲线理论，留学生首先会经历为期2—3个月的“蜜月阶段”，随后进入“文化冲击阶段”和“调整适应阶段”，研究发现留学生通过多种方式逐渐适应了中国的生活与文化后，会表现出对当地社会日益主动疏远的倾向。
Diabetes distress in patients with type 2 diabetes mellitus and obesity
Authors:   Pirogov Russian National Research Medical University, Sargsyan Ellen , Skuridina Darya ,   Pirogov Russian National Research Medical University
Published: January 2025

The aim. To determine the role of obesity in the development of diabetic distress in patients with type 2 diabetes, to identify clinical and
laboratory features of patients with type 2 diabetes and diabetic distress.
Material and methods. 152 patients (72 men and 80 women) with type 2 diabetes participated in the study, 76 of them were non-obese
(group 1), 76 had a BMI >30 kg/m2 (group 2). The average age of patients is 51 [40; 60] years. The experience of diabetes mellitus in the
studied patients is <10 years. All patients underwent the determination of HbA1c, waist circumference, diagnosis of diabetic distress using
a specialized PAID questionnaire and assessment of depression using the Beck scale. Statistical data processing was carried out using the
software packages Microsoft Excel 2016 and STATISTICA.
Results. Patients with type 2 diabetes and obesity have significantly more pronounced diabetic distress on the PAID scale, a higher level
of depression on the Beck scale, as well as a significantly higher index of HbA1c. In the group of patients with a high probability of diabetic
distress, the average level of HbA1c was significantly higher by 0.88%, and the waist circumference was 8.3 cm larger. As a result of
the correlation analysis, a direct correlation was revealed between waist circumference and the number of points according to the PAID
questionnaire.
Conclusion. Obesity in type 2 diabetes is a risk factor for diabetic distress and is associated with a higher risk of depression. Diabetic
distress is associated with higher values of HbA1c and the severity of abdominal obesity, which worsens the control of diabetes mellitus,
which means that it may indirectly increase the risk of complications. Understanding diabetic distress and effective management strategies
can significantly improve the effectiveness of treatment and improve the quality of life of patients with type 2 diabetes and obesity.
Long-term efficacy of metformin and primary prevention of complications of type 2 diabetes mellitus: Results from 42-year UKPDS follow-up
Authors:   Pirogov Russian National Research Medical University, Ushanova Fatima , Izmailova Tamara ,   Russian University of Medicine of the Ministry of Health of Russia, Bogacheva Tatyana ,   Pirogov Russian National Research Medical University
Published: January 2025

Metformin, long considered a mainstay of treatment for type 2 diabetes mellitus (T2DM), has recently received new evidence of its
effectiveness. Results from a 24-year follow-up of patients who completed the 20-year UKPDS study have demonstrated a significant
benefit of early metformin administration in preventing diabetes complications. The extension study included 1489 patients with a mean
age of 70.9 years. After 42 years of follow-up after randomization in the UKPDS, the metformin group retained a numerical advantage in
preventing T2DM outcomes compared with the sulfonylurea/insulin group: any outcome related to DM (18% vs. 10%), death related to DM
(25% vs. 16%), death from any cause (20% vs. 10%), myocardial infarction (31% vs. 17%). These results were significantly different from
the diet therapy group (p <0.05). Thus, metformin was found to have a primary preventive effect on the outcomes of T2DM, which persists
throughout almost the entire life of the patient with this disease.
Interdisciplinary approach to the management of diabetic retinopathy: The role of ophthalmologist and endocrinologist
Authors:   Pirogov Russian National Research Medical University, Demidova Tatiana , Shadrichev Fedor ,   Regional Endocrinological Center “City Consultative and Diagnostic Center No. 1”, Grigorieva Nyurguyana ,   Saint-Petersburg State University, Fisher Valentina ,   Regional Endocrinological Center “City Consultative and Diagnostic Center No. 1”, Ushanova Fatima ,   Pirogov Russian National Research Medical University, Nadybina Margarita ,   Pirogov Russian National Research Medical University
Published: January 2025

Diabetic retinopathy (DR) and diabetic macular edema (DME) are common chronic complications of diabetes mellitus, the fight against which is an urgent problem of modern healthcare. DR is the fifth most common cause of blindness worldwide and the main cause of vision loss in patients with diabetes. An interdisciplinary approach plays a key role in the effective management of DR, in which the role of the endocrinologist is to achieve optimal indicators of glycemic control as the main pathogenetic factor, and regular referral to screening of patients from risk groups. In turn, ophthalmologists are faced with the task of directly diagnosing changes in the fundus and treating eye diseases at various stages. Modern ideas about the mechanisms of development of DR and the role of VEGF allow us to identify several main areas of therapy. Thus, the main method of treating DR is laser retinal coagulation (LRC), and the most effective method of treating DME is considered to be a combination of LRC and intravitreal administration of angiogenesis inhibitors. Currently, intravitreal administration of agents that prevent the neoangiogenesis is the first-line treatment for DME involving the center of the macula. This review provides information on the pathogenesis, modern classification and current approaches to the management of patients with DR in the framework of the interaction of an ophthalmologist and an endocrinologist.
Making the Link between HRM and Sustainable Development: A Case for University Sector in KSA
Authors: Albaqami Adi Sudan
Published: January 2025

This paper discusses the relationship between human resource management (HRM) and sustainable development as well as examines how HRM strategies can serve as an opportunity for university sector in KSA to achieve sustainable development across all its dimensions including economic, social, technical and environmental.  To achieve these objectives, a theoretical framework was developed for examining HRM and sustainable development. A set of hypotheses was extracted from theoretical framework. To validate hypotheses, primary data were collected through a questionnaire that administered with 40 specialists and experts as well as 15 deans of faculties of business administration in Saudi universities. Then data were then analysed using SPSS. The Results showed that there was a strong link between HRM and sustainable development. Also, HRM strategies had a large effect on sustainable development dimensions (economic, social, technical and environmental).  The researcher recommends that priority should be given to investment in human capabilities and skills through the adoption of appropriate HRM strategies that improve HR performance and enable universities to achieve long-term sustainable development.
د هلمند په اوبیزه حوزه کې د سطحي اوبو آرزونه
Authors: صافی عبدالغیاث , رشتین صدیق الله
Published: January 2025

په تیرو څولسیزو کې د هلمند اوبیزې حوزې په ګڼ شمیر سیمو کې د نفوسو چټکې ودې، د اوبو ناسم مدیریت، د چاپیریال ستونزو، اقلیمي بدلونونو، د هوا ککړتیا، تپل شویو جګړو، مهاجرتونو او نورو لاملونو د اوبو زیرمې له هر پلوه زیانمنې شوې او آن په ځینو سیمو کې د وچیدو په حال کې دی. په دی لیکنه کې د هلمند په اوبیزه حوزه کې د اوبو ارزونې ته لنډه کتنه شوی، پر اوبو باندی د اقلیمي بدلونونو په تیره بیا د اوبو جریان، د هوا تودوخې درجی او اورښت اړوند څو کلن معلومات راټول او تر هراړخیزې څیړنې او ارزونې لاندې نیول شوی دی. د لیکنې په پای کې په هلمند اوبیزه حوزه کې رامنځته شوی ستونزې او زیانونه تر آرزونې لاندې نیول شوی او له مناسبو حل لارو وړاندیزونه شوی دی.
اثر باقی‌مانده‎‌‌های هورمون در گوشت و پی‌آمد آن بالای مصرف‌کننده‌گان
Authors: سخا محمد ظاهر
Published: January 2025

مشوق‏های نمو از مواد ساخته شده اند که در طبیعت خود مواد غیرغذایی بوده و برای حیوانات جهت بلند بردن سطح تولید، جذب مواد غذایی، مقاومت بدن حیوانات مقابل امراض و دیگر موارد مفید تجویز می‏گردند. هورمون‏ها هم مواد دیگر از جمله مشوق‏های نمو اند که بار اول در ایالات متحده امریکا و بعداً در کشورهای دیگر صنعتی داخل سیستم پرورش حیوانات گردید. با تجویز مواد مشوق نمو، سطح تولید و دوره تولید شیر بالا رفته و در میزان جذب شحم در انساج حیوانات کاهش به عمل آمده و هم‎چنان باعث انکشاف عضلات در حیوانات تولیدکننده‌ی گوشت می‎گردد. در بعضی کشورها استعمال مشوق‏های نمو؛ مانند انتی‌بیوتیک و هورمون منع قرار داده شده و تلاش‏ها صورت می‏گیرد تا جایگزین‏های مناسب به عوض انتی‌بیوتیک‏ها و هورمون‏ها در نظر گرفته شود.
مطالعه انتشار گازهای گلخانه‏‌یی در افغانستان
Authors: فقیری نسرین , قریشی رویا
Published: January 2025

افغانستان از جمله کشورهای آسیایی در انتشار تولید گازهای گلخانه‏یی است. هر چند این کشور از جمله آسیب‌پذیرترین کشورهای جهان در مقابل تغییرات اقلیمی و به‏گونه‌ی مشخص در ارتباط با آسیب‌پذیری از خشک‌سالی‎ها، سیلاب‎ها، لغزش‏های زمین و برفکوچ‎ها است. این آسیب‌پذیری‏ها تا حدودی مربوط به میزان در معرض حوادث طبیعی قرار داشتن است. با وجود این‌که آسیب‌پذیری نتیجه حساسیت بسیار بالای جمعیت افغانستان به‏حوادث غیرمترقبه‌ی طبیعی هم است. حساسیت چندین بُعد داشته و وابسته به عوامل اجتماعی-اقتصادی، فرهنگی و سیاسی است. توقع چندانی حداقل در کوتاه‌مدت تا میان‌مدت برای کاهش مقدار گازهای گلخانه‏یی از افغانستان وجود ندارد. زیرا با توجه به فقر و سطح نسبتاً پایین توسعه در کشور چنین توقعی نه واقع‌بینانه و نه هم منصفانه است. در رابطه با افغانستان، تضمین این‏که افزایش انتشار گازهای گلخانه‏یی که همراه توسعه کشور به پیش می‏رود، نهایتاً به نفع فقرا تمام شود، چالش اصلی است. زیرا این فقرا هستند که در برابر اثرات تغییر اقلیم از بیشترین آسیب‌پذیری برخوردارند.
شناسایی ترکیب و تسلسل امینو اسیدها در مالیکول های پروتئین
Authors: امین زی محمدطاهر
Published: January 2025

امینو اسیدها واحدهای ساختمانی تمامی پپتایدها و پروتئین‏های اند که بسیاری از خواص مهم فزیولوژیکی آن‎ها را تعیین می‎نمایند. امینو اسیدها در تجزیه غذا، رشد و ترمیم انساج بدن، ساخت هورمون، منبع انرژی، نگهداری سالم پوست، مو و ناخن، عضله‌سازی و تقویت سیستم ایمنی بدن کمک می‏کنند. بیش از ۵۰۰ نوع امینو اسیدهای مختلف در طبیعت شناخته شده است، اما تنها 20 نوع آن‌ها در ترکیب و سنتز پروتئین سهم می‏گیرند. تعیین ترتیب و تسلسل امینو اسیدها در یک پروتئین یا پپتاید اطلاعات مفیدی جهت درک ساختمان و فعالیت‎های فزیولوژیکی آن‎ها ارایه می‏نماید. در این مقاله‌ی مروری، روش‌های کیمیاوی مختلف مانند تجزیه ادمن، سنگــر و هم‏چنین معرف‌هــای کیمیاوی مختلف مانند ننهایدرین، کاربوکســی پپتایداز و هــایدرازین برای شناسایی ترکیب و تسلسل امینو اسیدها در مالیکول‎‌های پروتئین به بررسی گرفته شده ‌اند.
نقش تحصیلات‌عالی در توسعه و انکشاف اجتماعی افغانستان
Authors: رسول احمدرسول
Published: January 2025

مقاله‌ی حاضر به بررسی نقش تحصیلات‌عالی در توسعه و انکشاف اجتماعی افغانستان، اختصاص یافته است. مبرهن است که اساس پیشرفت و توسعه در ابعاد مختلف جامعه، بر دانش و تحقیق استوار است. توسعه‌ و انکشاف اجتماعی افغانستان در گرو رشد آگاهی‌ اجتماعی، انسجام و ‌هم‌بستگی اجتماعی، عدالت اجتماعی، رفاه اجتماعی، سرمایه اجتماعی و پیشرفت فکری و علمی مردم افغانستان می‌باشد. هدف تحقیق این مقاله را شناسایی نقش نظام تحصیلات عالی در توسعه و انکشاف اجتماعی افغانستان، تشکیل می‌دهد. در این مقاله، از روش تحقیق اسنادی و کتابخانه‌ای استفاده به‏عمل آمده است. یافته‌های این مقاله آن است که: نظام تحصیلات‌عالی کشور از طریق نصاب تحصیلی با کیفیت و مبتنی بر آموزه‌های اسلامی و دستاوردهای علمی می‌تواند در رشد آگاهی اجتماعی، تقویت وفاق و ‌هم‌بستگی اجتماعی، آموزش و تحکیم عدالت اجتماعی، تأمین رفاه اجتماعی، شناسایی مسائل اجتماعی و ارائه‌ی راهکار جهت تحقق انکشاف و توسعه‌ اجتماعی در افغانستان، نقش بنیادی و تعیین‌کننده را ایفا نماید.
نقش ژورنال‌های بین‌المللی در تقویت تحصیلات عالی
Authors: حامد اسدالله
Published: January 2025

ژورنال‌های علمی عبارت از سلسله نشراتی است که تحقیقات و دست‌آوردهای علمی پوهنتون‌ها، مؤسسات تحصیلی و نهادهای تحقیقی را به نشر می‌رساند. ژورنال‌های علمی در حقیقت اعتبار، ارزش و نقش تحصیلات عالی (پوهنتون‌ها و دیگر نهادهای تحصیلی) را جلوه می‌دهد. ژورنال‌های علمی در رده‌بندی‌های ملی و بین‌المللی تحصیلات عالی و پوهنتون‌های یک کشور نقش عمده و بسزایی دارد. متأسفانه تحصیلات عالی در افغانستان قربانی جنگ‌های طویل‌المدت داخلی و سیاست‌های نادرست حکومت‌ها بوده است و تا هنوز نتوانسته میکانیزم درستی برای ایجاد ژورنال‌های بین‌المللی را نهادینه نماید. هدف اساسی این مقاله بررسی نقش ژورنال‌های علمی در تحصیلات عالی افغانستان می‌باشد که اهمیت، ارزش و اعتبار ژورنال‌های علمی در تحصیلات عالی بیان گردیده است. در تدوین این مقاله از کتب و ژورنال‌های معتبر بین‌المللی استفاده صورت گرفته است. منحیث نتیجه، گفته می‌توانیم که تحقیق و نشر آن در ژورنال‌های علمی یگانه راه پیشرفت تحصیلات عالی است.
مروری بر چگونگی ساخت و ساز اکواریوم و مراقبت از آن
Authors: فرخاری سیدابراهیم
Published: January 2025

داشتن اکواریوم یکی از راهکارهای ارزان، قابل دسترس و مناسب برای تماس با طبیعت می‌باشد که در کاهش استرس و تزیین خانه و محل کار از جایگاه ویژه‌یی برخوردار است. در مرور حاضر اهمیت اکواریوم و روش ساخت و ساز آن (اجزا، مواد ساختمانی، شکل و اندازه و روش ساختن)، و چگونگی مراقبت از اکواریوم (شرایط آب، دوران مواد، مقدار مناسب ماهی در یک اکواریوم، انواع ماهی‌های اکوریومی و تغذیه آنها) به بحث گرفته شده است. محتوای این بحث برای اشخاص علاقه مند به داشتن اکواریوم و اکواریوم داران راهنمای خوبی بوده و  با نزدیکی افراد با طبیعت کوچک قابل دسترس در کاهش فشار روحی و تزیین خانه‌ها و محلات کار نقش اساسی داشته می‌تواند.
اثرات تغییر اقلیم بر اکوسیستم های جنگل
Authors: ستانکزی خالد
Published: January 2025

تغییر اقلیم یکی از بزرگترین چالش های جهان است و اثراتی مخرب و ناگوار بر اکوسیستم جنگل دارد. اکوسیستم جنگل با تغییرات آب و هوا حساس میباشد. بنابراین، تغییر اقلیم اثرات قابل توجهی بر تقسیمات انواع، رشد و ساختار جنگلات دارد. تغییرات آب و هوا با تغییر در رشد، مرگ و میر و تولید مثل درختان  در جنگل تاثیر می گذارد. افزایش درجه حرارت دوران زندگی درختان را با جوانه های زودرس، برگ دهی و گلدهی تغییر داده، و در مجموع تغییرات آب و هوا  اکوسیستم های جنگلی را به طور مستقیم و غیرمستقیم تغییر میدهد. افزایش درجه حرارت به طور مستقیم بر سرعت عملیه ترکیب ضایی و تنفس نبات و همچنین به طور غیرمستقیم با افزایش خطر هجوم آفات بالای ایکوسیستم جنگل تاثیر می گذارد. تغییر اقلیم بر دوران کاربن، ساختار جنگل، ترکیب انواع و عملکرد جنگل تأثیر می نماید.
مطالعه و بررسی بی‌ثباتی تعادل میخانیکی در سیستم چندین‌جزئی با گاز رقیق
Authors: ابتکار سیدسرور
Published: January 2025

سیستم‌های هایدروکاربنی از نظر تخنیکی با گاز چند جزئی مرتبط است؛ زیرا برای کاربرد در علم و تکنالوژی مخصوصاً برای غنی‌سازی مخلوط‌های گاز با اجزای خاص مورد استفاده قرار می‌گیرد. هدف از این مطالعه نقض و عدم تعادل میخانیکی در هنگام مخلوط کردن انتشار سیستم‌های چندجزئی و هم‌چنین مطالعه مناطق اختلال تعادل میخانیکی در یک مخلوط گاز سه‌‌جزئی با گاز رقیق است. در این مقاله باتوجه به شرایط و قاعده انتقال کتله گاز، مروری بر نتایج گرافیکی، پیشرفت‌های نظری، ریاضیکی و تخنیکی عدم تعادل میخانیکی گازات چندین‌جزئی با پارامترهای طراحی شده که عملکرد پدیده‌های انتقال کتله گاز را تحت تأثیر قرار می‌دهند و هم‌چنان چالش‌ها و محدودیت‌های به‌دست آمده از تجارب، مورد بحث قرار می‌گیرند. در نهایت مؤثریت گاز آرگون، نایتروجن، هلیوم، اکسجن و گاز کاربن در نقض تعادل میخانیکی مورد مطالعه و بررسی قرار می‌گیرند.
مروری بر نقش افلاتوکسین‌ها در ایجاد کارسینومای حجرات جگر
Authors: سنگری محمد
Published: January 2025

در کشورهای در حال توسعه مانند افغانستان سرطان دومین عامل مرگ­ومیر در انسان­ها شمرده می­شود. سرطان اولیه جگر تقریباً 4% کل موارد سرطانی جدید تشخیص شده در سطح جهان را تشکیل می­دهد. کارسینومای حجرات جگر در حدود 80% تمامی موارد سرطان جگر در جهان را تشکیل می­دهد. در ایجاد سرطان جگر به شمول ویروس­های هیپاتایت B و C، فکتورهای مختلف دخیل دانسته می­شوند. یکی از فکتورهای که در سال­های اخیر نقش آن در ایجاد کارسینومای حجرات جگر نه تنها در انسان­ها بلکه در اکثر حیوانات اهلی و تجربوی برجسته­تر شده می­رود، مایکوتوکسین­ها است. از میان مایکوتوکسین­ها، افلاتوکسین و مخصوصاً افلاتوکسین B1 از شناخته­ترین  عوامل کارسینومای حجرات جګر است که توسط آژانس بین­المللی تحقیقات سرطان به حیث سرطانزای ګروپ یک طبقه‌بندی شده است. هدف این مطالعه مروری، بررسی نقش افلاتوکسین­ها در کارسینومای حجرات جگر و میکانیزم سرطان‌زایی آن­ها است.
مطالعۀ ویژه‌گی‌های کرستال‌های مایع
Authors: عزیز عبدالمحمد
Published: January 2025

کریستال مایع مقدار از نظم جامدات و مقدار از سیال بودن مایعات را دارا است، کریستال‌های مایع در هر لحظه می‎توانند به یکی از چندین حالت ممکنه بین جامد و مایع موجود باشند. کرستال‌های مایع عبارت از مرکبات عضوی اند که دارای مالیکول‎های طویل بوده و در انتهای آن‎ها گروپ‌های قطبی (NO2, -OR--CN, -NH2, ) موجود بوده و در بعضی اوقات قطعات مانند حلقۀ بنزین را نیز شامل این مواد می‎سازند. مالیکول‎های این مرکبات دارای ساختمان خطی بوده؛ اما برای گروپ‎های مرکزی آن‎ها به‌طور مشخص موجودیت روابط دوگانه بین دو اتوم‎ آن‌ها حتمی است. رابطۀ دوگانه مانع چرخش و سختی مالیکول‎ها را با در نظر داشت نسبت محور طویل آن‎ها تأمین می‎نماید، این مالیکول‎ها حاوی گروپ‎های باداشتن قطبیت بلند بوده، دیپول مومنت آن‎ها بزرگ است . مالیکول‎ها در کریستال مایع به طور لازمی از لحاظ مکانی منظم نه‎بوده؛ اما در سه جهت می‎تواند آزادانه سمت‌گیری داشته باشند. در این مقاله مروری ویژه‌گی‌های چون خواص، ساختار و ترکیب کریستال مایع مورد بررسی قرار گرفته اند.
Analysis of the determinants of Indonesian rubber exports
Authors: Rani Kartika  , Ahmad ridha  , Miswar
Published: January 2025

This study investigates the impact of domestic rubber prices, world rubber prices, rubber production volume, and exchange rates on the volume of Indonesian rubber exports from 2001 to 2021, both simultaneously and partially. Secondary data were collected from the Central Bureau of Statistics' website for the specified period. The analysis was conducted using multiple linear regression, with hypothesis testing carried out through t-tests and F-tests. The findings reveal that, individually, domestic rubber prices, world rubber prices, and exchange rates do not significantly influence the volume of Indonesian rubber exports. However, rubber production volume demonstrates a significant effect. Simultaneously, domestic rubber prices, world rubber prices, rubber production volume, and exchange rates collectively have a significant impact on the volume of Indonesian rubber exports. These results underscore the critical role of production volume in driving export performance, offering valuable insights for policymakers and stakeholders in the rubber industry.
"Das ungewisse” : the uncertain time of Paul Celan’s “Grabschrift für François”
Authors:   , Sax Adam Marcus
Published: January 2025

This dissertation is a detailed study of the poem “Grabschrift für François” [Epitaph for François], written by the Holocaust survivor and mid-20th-century German-language poet, Paul Celan. Celan’s poetry is regarded in the scholarship as a site of mourning for the brutalities of the Holocaust, including the murders of his parents. “Grabschrift für François,” however, marks a critical point of loss for Celan that post-dates those losses from the Holocaust, deaths with which his poetry is traditionally associated. The poem’s title points to Celan’s most significant loss since the end of the Holocaust, the death of his first-born son, François, on October 8th, 1953. This dissertation remains with this poem and its treatment of this death in order to re-orient the way we think about loss in Celan’s oeuvre. In order to do so, the project examines the figures, form, and unique language of this poem through a detailed close-reading. This reading is informed by Celan himself—his speeches, letters, and other archival materials—along with scholarly works from the fields of psychoanalysis, continental philosophy, and contemporary literary theory. Through this analysis we come to the intervention of “uncertain time,” time that has encountered loss and loses its linearity, predictability, and measurability. This is “time out of joint” or time at odds with itself, that is, time “in contretemps.” Such time produces a specific kind of relationship of the survivor to loss, that of the “exilic mourner.” It is through these various interventions that I conclude that uncertain time is not simply an idea but part of the poem, part of the poetic structure of the text, that serves to keep the poem—in Celan’s own terms—“speaking” of loss.
Network slicing for QoS and QoE driven network management
Authors:   , Miranda Gilson
Published: January 2025

Computer networks are becoming increasingly complex, with several interconnected devices, protocols, control knobs, and applications sharing a physical infrastructure. Different applications can have different Quality of Service (QoS) requirements to operate correctly. The user-perceived experience, i.e., Quality of Experience (QoE), when consuming network applications is also a relevant indicator that must be accounted for, to minimize customer churn and offer a satisfactory experience to the users. Such complexity of the networks and applications makes it difficult for network operators to define a one-fits-all configuration or manually set device parameters tailored to each application. Thus, automating the configuration of network functions and enabling the allocation of the appropriate resources for each application is crucial to support the scaling of future networks. To realize this automation, several components are required for monitoring network performance, acting to control the behavior of network flows, and managing the available resources to accommodate the different applications sharing the infrastructure. Network slicing is one of the main technologies enabling such tailored configurations, but other supporting enablers must still be integrated and combined into an overarching solution. This thesis presents solutions tackling the different activities required for automating the management of network slices including real-time monitoring of their performances, estimating user experience when applicable, exerting control over network flows, and automatically adjusting resources in the face of issues. Therefore, we build a complete solution to realize network slicing using both QoS and QoE measurements as feedback signals, implemented in real devices with a strong experimental component. Each component presented in this thesis was experimentally evaluated using real testbeds including wired and wireless segments, highlighting the feasibility of our solutions.
'Les armes de la critique' : het sociaal-cultureel narratief van de muziekjournalist: Belgische muziek- en kunsttijdschriften en hun melomaan publiek (1830-1880)
Authors:   , Van der Heyden Joanna
Published: January 2025

Musicologists study musicians, music genres, and musical practices. In recent decades, it has become increasingly clear that not only artistic but also social conditions within the classical music scene have had a significant impact on music perception and the preferences of music lovers. These insights have led to renewed analyses by musicologists and cultural historians of nineteenth-century music journals, with music critics and journalists being brought into sharper focus. Music journalists played a central role in shaping the performances of musicians and guiding enthusiasts in developing their musical taste. However, their influence extended beyond the musical context. This dissertation thus deviates from a purely musicological approach and examines the socio-cultural dimension that also emerges in the discourse of the authors. On the one hand, it sketches a portrait of the music journalist. It explores who was allowed to speak as a legitimate voice on music between 1830 and 1880. On the other hand, it shows that any socio-cultural theme could be picked up by the music press and subjected to commentary.The dissertation analyzes how male journalists, between 1830 and 1880 – in a time when female colleagues were barely visible – earned their place in art criticism and what obstacles they overcame in the process. Although their work was likely poorly financially rewarded, they had considerable societal influence. Music was presented by them as a profound means of social regulation, although they were by no means averse to superficial gossip. From a predominantly anticlerical, liberal stance and with an urban perspective that often looked down on rural life, they contributed to the social and political discourse. Their powerful position allowed them to spread certain societal norms and communicate the appreciation – or lack thereof – for Western European music culture. This discourse also fed a nationalist sentiment, which in the 1880s led to tensions between European countries.Despite their influence, music journalists did not become a driving force of social change. Articles about the position of the musician remained scarce, and the audience of the magazines was composed mainly of affluent readers with possibly little engagement in social reforms. Female artists, including famous divas, and the female audience were judged according to the conventions of bourgeois society. Between 1830 and 1880, there was barely any emancipatory voice in the music press. It primarily reinforced existing structures and upheld the bourgeois identity.
Áp dụng kiểm định chéo để cải thiện phương pháp Lasso dạng đồ thị trong lựa chọn danh mục đầu tư tối ưu
Authors: Nguyễn Minh Nhật  , Nguyễn Đức Trung
Published: January 2025

Nghiên cứu này tập trung vào việc cải thiện hiệu quả của phương pháp Lasso dạng đồ thị (Graphical Lasso) trong lựa chọn danh mục đầu tư (DMĐT) tối ưu thông qua kỹ thuật học máy áp dụng kiểm định chéo (Cross Validation - CV). Graphical Lasso, một công cụ mạnh mẽ trong việc ước lượng ma trận hiệp phương sai (MTHPS) để tối ưu hóa phân bổ tài sản, thường gặp khó khăn trong việc lựa chọn tham số điều chỉnh α, đòi hỏi kinh nghiệm từ người sử dụng. Bằng cách tích hợp kỹ thuật CV, nghiên cứu nhằm tự động hóa và tối ưu hóa quá trình này, cải thiện độ chính xác và tính ổn định của mô hình. Dữ liệu được thu thập từ Sở Giao dịch Chứng khoán Thành phố Hồ Chí Minh trong giai đoạn từ ngày 01/01/2019 đến ngày 31/12/2023. Kết quả cho thấy sự kết hợp giữa kỹ thuật CV và phương pháp Graphical Lasso (GraphicalLassoCV) không chỉ nâng cao hiệu suất đầu tư mà còn giảm thiểu rủi ro so với các phương pháp truyền thống, giúp xây dựng DMĐT tối ưu và mang lại giá trị thực tiễn cao cho nhà đầu tư.
Da exclusão ao exercício da função autor
Authors: El-Jaick Ana Paula , Servelati Fabrício
Published: January 2025

Esta é uma breve análise discursiva foucaultiana da posição sujeito indígena tal como foi discursivizada pelos primeiros colonizadores europeus, e, contemporaneamente, da função de autor exercida por indígenas. Revemos aqui o pensamento de Foucault sobre a função-autor à luz de questões decoloniais atuais, e reivindicamos a oralidade e o corpo como dispositivos a serem considerados também como constituintes da posição do autor indígena.
Biopolítica, Necropolítica e Decolonialidade Interseccional em algumas análises dos racismos de Estado e sociedade no Brasil
Authors: Silveira Lemos Flavia Cristina , De Souza Silva Ikuma Jéssica Lanne , Ferreira Pinheiro Ronaldo
Published: January 2025

O artigo teve o objetivo de analisar a biopolítica, a necropolítica e a decolonialidade sob a articulação com a interseccionalidade para colocar em crítica o racismo de Estado e de sociedade, no Brasil, especialmente por alguns aspectos do Brasil República. Buscou-se problematizar o deixar morrer de mulheres negras, sob a insígnia de democracia racial e mestiçagem como dispositivos de governo da população. Ainda foi realizado um olhar em perspectiva de aspectos dos feminismos negros na criação de efeitos políticos importantes nas resistências à negação do racismo e da violência de gênero como marcadores sociais que andam conjuntamente na prática de deixar morrer e matar em nome da vida. Por fim, aponta-se a relevância de trabalhos que tragam estas articulações conceituais e metodológicas como operadora de ruptura com os racismos de sociedade e de Estado, no presente brasileiro.
PENGARUH KOMPETENSI DAN ADAPTIBILITAS TERHADAP KINERJA KARYAWAN DENGAN SELF EFFICACY SEBAGAI VARIABEL INTERVENING PADA KARYAWAN
Authors: Elza Arindani Dwi Putri Aprilian  , Heri Prabowo  , Noni Setyorini
Published: January 2025

This study aims to examine the influence of competence and adaptability on employee performance, with self-efficacy serving as an intervening variable among employees of PT KAI (Depo Lok SMC). The background of this research lies in the inconsistencies found in previous studies, indicating instability in perspectives within the existing literature on the topic. These differences highlight the need for further investigation to clarify the relationships among the variables being studied. The research adopts a quantitative method, with the population consisting of all employees of PT KAI (Depo Lok SMC). The study employs a saturated sampling technique, involving the entire population of 59 respondents. Data collection was conducted using a questionnaire designed to measure competence, adaptability, self-efficacy, and employee performance. The data collected were analyzed using the Structural Equation Modeling (SEM) technique, facilitated by the SmartPLS3 software. The findings reveal that competence has a positive impact on employee performance, while adaptability does not significantly affect performance. Additionally, competence positively influences self-efficacy, and adaptability also shows a positive effect on self-efficacy. However, self-efficacy does not have a direct impact on employee performance. Furthermore, the study found that competence and adaptability do not influence employee performance when mediated by self-efficacy. These results provide new insights into the critical role of competence in directly enhancing performance, while self-efficacy is not strong enough to act as a mediating variable. This study contributes to the existing literature by offering a deeper understanding of the relationships between competence, adaptability, self-efficacy, and employee performance.
ANALISIS STRATEGI PEMASARAN ONLINE DAN OFFLINE DALAM MENINGKATKAN PENJUALAN DAN KEBERHASILAN BISNIS PADA BUTIK KAYLA WATI
Authors: Kusniyah Kusniyah  , Chandra Lukita  , Ni Wayan Fitriana Ayu Lestari
Published: January 2025

The existence of this online media platform has a very dynamic and efficient role in supporting business activities. This study aims to determine the marketing strategy carried out by Kayla Wati Boutique Krangkeng Indramayu. This type of research is qualitative research with data collection techniques in the form of observation, interviews and documentation. The results showed that Kayla Wati Boutique's online system marketing strategy is to hold promotions on social media to attract consumer interest, the quality of goods or products displayed on social media must be exactly the same as the products to be sent to avoid consumer complaints.