bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Kinematika Trajectory Lingkaran pada Robot Roda Mecanum
Authors: Fahmizal Fahmizal , Priyatmoko Angga , Mayub Afrizal
Published: July 2022

Abstract - The movement of the non-holonomic mobile robot is still not efficient because it can only move forward, backward, and turn so that it requires a wheel platform that is able to move more efficiently and more variedly. The use of mecanum wheels on wheeled robots is one of the best solutions because the mecanum wheels can move in all directions and are more stable. This paper proposes a mechanical robot trajectory kinematics design with a simple and easy mechanism to implement using an embedded system such as using Arduino. From the results of this study, it was found that the robot was able to maneuver following a circular trajectory with a radius of 50 cm in 7 seconds.Keywords - mobile robot, mecanum robot, inverse kinematics, trajectory Intisari - Pergerakan mobile robot non holonomic masih belum efisien karena hanya dapat bergerak maju, mundur, berbelok sehingga membutuhkan platform roda yang mampu bergerak lebih efisien dan lebih variatif. Penggunaan roda mecanum pada robot beroda menjadi salah satu solusi terbaik karena roda mecanum dapat bergerak ke segala arah dan lebih stabil. Makalah ini mengusulkan sebuah perancangan desain kinematika trajectory robot mecanum dengan mekanisme yang sederhana dan mudah untuk diimplementasikan menggunakan embeded system seperti menggunakan Arduino. Dari hasil penelitian ini diperoleh bahwa robot mampu bermanuver mengikuti trajectory lingkaran  dengan radius 50 cm dalam waktu 7 detik.Kata kunci - robot beroda, roda mecanum, invers kinematika, trajectory
Development of Techno-Pedagogical Skills among Teacher Educators: The Case of Higher Technical Teachers’ Training College of the University of Buea, Cameroon
Authors: Ngale Lyonga Ngemunang Agnes , Nkeng Asobo Jackson
Published: July 2022

The aim of this study was to investigate teachers’ perception of techno-pedagogical skills in HTTTC Kumba. It was hypothesized that the perceived usefulness of techno pedagogical skills has no significant effect on teachers’ performance in HTTTC Kumba. 42 teachers of HTTTC were sampled by multistage sampling technique and administered a questionnaire. The data were analyzed using frequencies and percentages for descriptive statistics, while the Chi-Square Test was used for testing the hypothesis. The results indicated a significant positive perception of technology among teachers in HTTTC Kumba despite the limitations and non-acceptance of technology demonstrated by some teachers in their responses. It was recommended that the teachers and teachers in training could be encouraged to have a more positive attitude towards the use of technology in their classrooms by providing the right infrastructure and provision for them to get technology-related help when needed.
A Study of Socio-Political Manipulation in Bhisham Sahni’s Tamas
Authors: Revathy S. , T. Senthamarai Dr.
Published: July 2022

Ernest Benn, said that, “Politics is the art of looking for trouble, finding it everywhere, diagnosing it incorrectly and applying the wrong remedies.” As the lines suggested, Tamas, elucidates the tragic politics behind communal riots by generating a false violation. The notable themes of Tamas include institutional violence, religious identity, communal politics and female centric assaults. This novel addresses the outcome of institutionalised violence and imposed ethnic conflict. The objective of the paper is to analyse socio-political manipulation and communal clashes in Tamas.
Rangeland Degradation and Rehabilitation: Indigenous Ecological Knowledge and Perceptions of Pastoralists in the Adamawa High Plateau of Cameroon
Authors: Awalu Adamu Mbah , Nformi Manu Ibrahim
Published: July 2022

Pastoralists’ perceptions and indigenous ecological knowledge of vegetation changes are often ignored despite the debate about their role in rangeland management. Yet, pastoralists are known to have extensive ecological knowledge which could complement scientific knowledge and contribute to improved understanding and sustainable management of savanna Ecosystems. This study was aimed at exploring pastoralists’ perceptions regarding rangeland degradation in the Adamawa highland plateau. More specifically, it was geared to examine their awareness of rangeland degradation, the current status/condition of the rangelands, the drivers and major root causes of degradation, negative consequences, existing management practices, and a methodological framework to make these measures more resilient. The study applied a descriptive statistics method. Focus group discussions, field observations and structured/semi-structured survey questionnaires, were used for data collection, where 240 pastoralists were targeted. The study covered 4 sub-divisions within Faro & Deo District of the plateau based on the intensity of degradation (high, medium and less). The major findings indicate that, the main livelihood activity is cattle rearing and crop cultivation (86.43%) with a certain degree of sedentarization. The major livestock production constraint proved to be insufficient and poor pasture available for cattle (65.71%). A great majority (93.6%) also confirmed that the present rangeland state/condition has become poor and non-conducive for cattle production. This is clearly interpreted in the drastic drop of the ‘cheptel’ (average holdings) and a decline in the quality of pastoral resources/outputs offered to the communities. The major root causes of degradation were overgrazing, bush encroachment, uncontrolled bush fires, soil erosion, population pressure and limited care/attention paid to rangelands. The major socio-economic consequences were poverty, food insecurity, conflicts, loss of cultural heritage, rural exodus and high crime waves. Through their indigenous ecological knowledge pastoralists conserve their rangelands through: mechanical and chemical fight against bush encroachment (Bush clearing and use of selective herbicide respectively), seasonal herd mobility/transhumance, use of paddocking systems, destocking of herds, adoption of improved pastures, and improvement on pastoral hydraulics. Government and NGOs’ supports to rangeland management, proved to be limited in the study area. The degradation of rangelands in the study area is progressing at an alarming rate which gives the impression of difficulty to restore it in the future if proper measures are not taken by stakeholders.
Assessing community members’ knowledge and attitude towards Community-Based Education practices in Southern Ethiopia
Authors: Haligamo Demamu , Honja Selamawit , Tagele Deborah
Published: July 2022

The study conducted by the University of Gezira in Sudan indicated that many institutions are not involving the community in the process of Community-Based Education (CBE) program evaluation. Moreover, the community feels that the program is being imposed upon them rather than being available for them. This study aimed to assess community knowledge and attitude towards university health students’ CBE practices and associated factors. The community-based cross-sectional study through systematic random sampling method was conducted on 394 households. Descriptive statistics and logistic regression analysis were conducted by using Statistical Package for Social Science (SPSS) Version.23. Of the 394 individuals interviewed, 188 (47.7%) of them were found to have good knowledge and 229 (58.1%) have good attitude on CBE practices. Concerning the determinant factors, educated respondents, high-income respondents, and student and government employee were likely to have better knowledge of CBE practices than others. In addition, students and government employee also likely to have better attitude towards CBE practices than other occupations. Community members’ knowledge and attitude on certain aspects of the CBE practices were still poor. Thus, the awareness and large participation of community members in the program are needed to increase the popularity of the program.
Empowering entrepreneurship competences through socialization of educational entrepreneurship for elementary school teachers in Jakarta
Authors: Marini Arita , Safitri Desy , Lestari Ika , Zahari Musril , Iskandar Rossi , Sudrajat Ajat , Nuraini Sri , Rihatno Taufik , Suntari Yustia , Nafiah Maratun , Siregar Rosinar
Published: July 2022

Partner of this international collaboration of community service is Konstanz University of Applied Sciences in Germany, Prof. Dr. Christian von Lübke, to be invited to collaborate in giving socialization about educational entrepreneurship for elementary school teachers in the province of Jakarta Indonesia.  The target of this community service is elementary school teachers in the Province of Jakarta Indonesia.  The socialization of educational entrepreneurship for elementary school teachers was done to develop entrepreneurship competences of elementary school teachers in the Province of Jakarta Indonesia, the solution undertaken was socialization of educational entrepreneurship.  The methods used in conducting this international collaboration of community service were cooperative learning, problem-based learning, and giving assignments.  This socialization was conducted through video conferences in the form of learning activities to improve the competence in educational entrepreneurship for elementary school teachers in the province of Jakarta Indonesia. The socialization of educational entrepreneurship given is related to developing entrepreneurial interest with appropriate learning activity programs. This international collaboration of community service was conducted at elementary schools in the Province of Jakarta Indonesia because those elementary schools are regularly empowered by Universitas Negeri Jakarta.  Based on evaluation measurement, teachers’ interest in entrepreneurship education reached 86,75 % and the average satisfaction level of participants were 94%.
Processed fish products based on diversification and standardization
Authors: Purwanto Edy , Isdiantoni I. , Syahril S.
Published: July 2022

Pagerungan Besar is one of the villages in Sapeken District, Sumenep Regency with the potential for marine products that are very plentiful. Business actors engaged in the fish processing industry in Pagerungan Besar Village are currently experiencing problems are understanding product diversification from processed fish and fish processing processes according to the Indonesian National Standard. This activity aims to provide an understanding to fishermen and business actors (processed fish) in Pagerungan Besar regarding innovative fish processed products and fish processing processes according to SNI Activities are carried out in the form of socialization and training. The service that is packaged in socialization and training activities has been prepared since Monday, May 31, 2021, and will be held on Friday, October 15, 2021, at the Pagerungan Besar Village Hall. Participants know the products that can be produced both during the pre-test and post-test. The results of the pre-test and post-test conducted showed that there was an increase in participants' knowledge of the SNI from 6 people (20%) to 30 people (100%). Participants' knowledge about product diversification from fish waste has increased significantly from 6 people (20%) to 30 people (100). Through this activity, participants gained a lot of knowledge in terms of product innovation, i.e., fish heads, tails, scales can be processed into high-value products and fish processing with Indonesian National Standards (Standar Nasional Indonesia/SNI).
Innovation integration of Islamic values in learning environmental themes in biology education
Authors: Husamah H. , Suwono Hadi , Nur Hadi , Dharmawan Agus
Published: July 2022

This article aims to analyze the innovation of integrating the values ​​of Islamic Values in learning environmental themes in the Biology Education Study Program at Muhammadiyah Higher Education. It is library research with qualitative data based on the secondary data. The source triangulation technique was employed to check the data validity. The obtained data were analyzed using descriptive qualitative analysis using VOSviewer software, which are described through the results of behaviour and sentences observed by the researcher. Content analysis was employed as the analysis technique. the results showe 17 formulations of the importance and urgency of Islamic Values and 12 formulations of Islamic Values ​​and their integration in learning environmental themes. This means that Islamic Values need to be integrated into learning environmental themes in the Biology Education Study Program at Muhammadiyah Higher Education along with the learning model. Among the model that can be used is integrative STAD type Cooperative Learning and Project-Based Learning
A Retrospective Study of the Effectiveness and Safety of Banhasasim-tang, Gumiganghwal-tang, or Pyeongwee-san in Patients with Type 2 Diabetes Mellitus
Authors: Oh Seung-hyun , Lee Min-seong , Jung Woo-nyoung , Noh Ji-won , Ahn Young-min , Ahn Se-young , Lee Byung-cheol
Published: July 2022

Objective: This study was conducted to evaluate the hypoglycemic effect and safety of herbal extracts in patients with type 2 diabetes mellitus.Methods: We investigated 19 hospitalized patients with type 2 diabetes mellitus who were administered Banhasasim-tang (BST), Gumiganghwal-tang (GGT), or Pyeongwee-san (PWS) at Kyung Hee University Korean Medical Hospital for at least three days between January 2012 and December 2021. Their clinical characteristics and laboratory tests were reviewed retrospectively. The glucose-lowering effect of the herbal extracts was assessed by comparing blood glucose levels, including fasting blood sugar (FBS), two-hour postprandial glucose (PP2) levels, and glycated hemoglobin levels. To evaluate the safety of the herbal extract, liver function test and kidney function test results were compared, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine (Cr).Results: After taking herbal extracts, PP2 and HbA1c levels significantly decreased from 205.82 mg/dL to 171.41 mg/dL and 7.58% to 6.62%, respectively. The safety profile reported no significant difference after taking herbal extracts.Conclusions: BST, GGT, and PWS may have hypoglycemic effects in patients with type 2 diabetes mellitus taking hypoglycemic medication.
Comparison of Clinical Characteristics of Patients between Genuine and Pseudo Halitosis
Authors: Keum Chang-Yul , Lee Hyun-Jin , Cho Yun-jae , Han Aram , Yoon Chae-Rim , Choi Su-Hyun , Ha Na-yeon , Kim Jinsung
Published: July 2022

Objectives: This study was designed to investigate the difference between genuine and pseudo-halitosis in terms of clinical characteristics.Methods: We recruited 51 halitosis patients who visited the halitosis clinic at Kyung Hee University Korean Medicine Hospital from March 2020 to March 2022. We classified the halitosis patients into two groups, genuine and pseudo halitosis, based on oral chroma and evaluated the status of hyposalivation using the drainage method, stress levels using heart rate variability (HRV) parameters, and Ryodoraku.Results: Comparing the genuine halitosis group and the pseudo halitosis group, there was no significant difference in the status of hyposalivation and HRV parameters. However, Ryodoraku was significantly different between genuine and pseudo halitosis. Compared to the genuine halitosis group, the pseudo halitosis group showed a significantly higher value of total average (TA) of Ryodoraku.Conclusion: The results of this study suggest that there is a significant difference in Ryodoraku between genuine halitosis and pseudo halitosis, so when approaching pseudo halitosis patients, we should consider their excitability of the sympathetic nervous system and metabolic function status.
One Case of Myelodysplastic Syndrome Treated with Herbal Medicine
Authors: Hwang Cho-Hyun , Kim Eujin , Lee Juyoung , Jang Eungyeong , Lee Jang-Hoon , Kim Youngchul
Published: July 2022

Objectives: The aim of this study was to identify the effects of herbal medicine on the clinical symptoms and abnormal blood tests of a patient with myelodysplastic syndrome.Methods: A 64-year-old woman diagnosed with myelodysplastic syndrome in 2020 was prescribed Bojungikgi-tang-gagambang from January 6, 2022 to June 22, 2022 to reduce bleeding tendency and frequent defecation and to improve laboratory findings, such as platelet count. We observed changes in the symptoms and improvement of laboratory findings after six months of treatment.Results: In this study, approximately six months of treatment with Bojungikgi-tang-gagambang showed considerable improvement in laboratory findings and clinical symptoms, especially frequent defecation, petechiae, and gum bleeding, compared to the baseline parameters of the first visit. Also, no adverse effects, such as liver injury or decreased kidney function, were observed during herbal medicine treatment.Conclusion: This study suggests the availability of herbal medicine as a therapeutic option for managing patients with myelodysplastic syndrome.
Measurement-based generation and preservation of cat and grid states within a continuous-variable cluster state
Authors: Eaton Miller , González-Arciniegas Carlos , Alexander Rafael N. , Menicucci Nicolas C. , Pfister Olivier
Published: July 2022

We present an algorithm to reliably generate various quantum states critical to quantum error correction and universal continuous-variable (CV) quantum computing, such as Schrödinger cat states and Gottesman-Kitaev-Preskill (GKP) grid states, out of Gaussian CV cluster states. Our algorithm is based on the Photon-counting-Assisted Node-Teleportation Method (PhANTM), which uses standard Gaussian information processing on the cluster state with the only addition of local photon-number-resolving measurements. We show that PhANTM can apply polynomial gates and embed cat states within the cluster. This method stabilizes cat states against Gaussian noise and perpetuates non-Gaussianity within the cluster. We show that existing protocols for breeding cat states can be embedded into cluster state processing using PhANTM.
Problems and benefits of implementing BIM in the construction industry
Authors: Iushkin Ivan I. , Alamedy Shaimaa Ghanim Hakim , Stashevskaya Nadezhda A.
Published: July 2022

The construction industry is one of the important pillars of the economy. Building Information Modeling (BIM) is a set of technologies that aims to enhance collaboration across the architecture, engineering, and construction industries to improve the productivity and quality of the design, construction, and maintenance phases of a building. Rethinking construction is the key to increasing productivity. However, BIM has not been widely adopted in the construction industry. It is necessary to understand the main problems hindering the implementation of BIM, consider the appropriate strategies that can be applied to gain a deeper understanding of BIM, conduct a comprehensive and systematic analysis of the factors influencing the implementation of BIM. Based on a literature review, a questionnaire survey and the collection of statistical data, factors of a negative impact on the implementation of BIM were identified. The results show that key factors influencing BIM adoption include a lack of trained professionals, of investment in staff training, of BIM standardization, as well as the position of leadership in organizations. This article puts forward some proposals to promote the implementation of BIM and specific measures to implement the widespread use of BIM technology in the construction industry.
A Poeteme as a Tool for the Analysis of a Lyrical Text in L.A. Novikov’s Concept of Language as Art
Authors: Temirgazina Zifa K.
Published: July 2022

The purpose of this study is to demonstrate the methodological, “instrumental” potential of some theoretical concepts developed and deepened in the concept of language as a verbal art by Lev Alekseevich Novikov - poetemе and ostrannenie (alienation). The lyric poetry of Pavel Vasiliev, the Russian Soviet poet (1910-1937), whose work is of a transcultural nature and belongs to the “literature of the borderland”, is analyzed. The poetemes “a steppe - a parent” and “a steppe - an ancient mysterious land” are modeled, allopoets are defined, in which the image of the steppe, key for the poet, is presented; the linguistic means of creating aesthetic imagery in allopoets are identified. The concept of a poeteme allows one to compare different images and interpretations in the poet’s work, draw connecting lines between them and ultimately determine the originality of the individual author’s poetic picture of the world. The method of the ostrannenie was introduced into scientific circulation by V.B. Shklovsky; in Novikov’s concept it appears as an invariant of linguistic imagery, which includes traditional tropes and figures as special cases. For the ostrannenie in his poetics Vasiliev uses the method of breaking stereotypes, which allows him to attract the attention of the reader, making the image unusual and alien. The article provides examples of violation of poetic stereotypes inherent in Russian poetry: the symbol of poetry - a goose feather, sound like silver, as well as a typical for Vasiliev method of violating ethnic stereotypes, for example, appearance: attribution of Asian features to a lyric hero - slanting eyes, cheekbones, etc. Thus, a broad understanding of ostrannenie in Novikov’s theory makes it possible not only to fundamentally unite traditional tropes and figures, but also includes specific individual author’s techniques of poetic technique.
Hypotyposis in Heterogeneous Screen Texts: Case Study of ASMR-Videos
Authors: Evgrafova Yulia A.
Published: July 2022

This article examines the peculiarities of the functioning of the rhetorical figure hypotyposis in an atypical for its nature type of the text - a heterogeneous screen text. The relevance of the study is determined by the supremacy of such texts in modern communication and their increasing influence on the formation of public opinion, including the use of implicit manipulations, constructed by rhetorical means. The aim of this article is to examine means of constructing hypotyposis in heterogeneous screen texts. ASMR-videos published on the online platform YouTube were chosen as the research material. Descriptive techniques (observation; generalization; interpretation of observation results; classification; analysis; synthesis; comparison), contextual and distributive analysis, as well as functional-pragmatic analysis were chosen as the research methods. The following results were found in the course of the study. In heterogeneous screen texts, in particular ASMR-videos, the hypotyposis is constructed on the basis of metonymic and metaphorical connection arising between the verbal and non-verbal units in the course of their constellation in the screen “speech”. It is regulated by the analytical synaesthetic code, which has a number of subcodes: auditory-visual, visual-auditory, visual-tactile and visual-objective. The use of hypotyposis in ASMR screen texts “depicts” the invisible - the viewer-recipient experiences certain perceptual sensations from stimuli that do not really exist - a simulation of reality. Besides, a semiotic “nest doll” of codes allows to control the consciousness of the spectator-recipient, creating fascination. This article is aimed at students, graduate students, teachers, linguists, philologists, and anyone else interested in general and linguistic semiotics.
Images of Nature in Tuvan, Tatar, Russian, and Spanish Riddles
Authors: Chesnokova Olga S. , Usmanov Timur F.
Published: July 2022

The article offers evidence of contrastive ethnolinguoculturological analysis of images of major natural phenomena (the sun, the moon, the day, the night, the stars, the wind, the rain, the snow/ice) in the riddles of four folk cultures that belong to Turkic (Tuvan and Tatar), Slavic (Russian), and Romance (Spanish) linguocultures, with interpretation of peculiarities of the poetics. Nature binds together different levels of cognition, evokes imaginative associations, refers to the archetypal constants of mythopoetic creativity. Riddles about nature are presented in the verbal creativity of any ethnic group. Theoretically and practically, it is important to develop a unified ethnolinguoculturological approach to study the poetics of thematically identical riddles of multilingual cultures. The subject of the article is riddles about nature, the object is linguistic means that create images of the sun, the moon, the day, the night, the stars, the wind, the rain, the snow/ice in Tuvan, Tatar, Russian-speaking, and Spanish ethnic groups. In the study, around 400 Tuvan, Tatar, Russian and Spanish riddles about nature from books on Tuvan, Tatar, Russian and Spanish folklore were used, along with riddles found on the Internet. The study methods include semantic, interpretative, linguoculturological analysis, culturological commentary, and comparative analysis. The main objective of the article is to analyze models of figurative representation and poetics of nine natural phenomena in four linguocultures. The article establishes that the ethnolinguistic content and poetics of riddles about nature vary depending on objective natural and geographical factors, dominant folk worldview, and typological affiliation of languages. The most numerous and metaphorically branched in all four linguistic cultures were the riddles about the sun, the wind, and the moon . The investigated riddles about nature show the characteristic determinant of the Turkic and the sporadic determinant of the Russian and Spanish riddles. The similarity of the images suggests a Eurasian continuum of riddles about nature.
The Effect of Surfactants on Separation of Light Rare Earth Metals using Emulsion Liquid Membrane Method: Review
Authors: Setiani Dwi Ratna , Widianti Afifah R. , Salsabila Fauzia , Anggraeni Anni , Bahti Husein H. , Pratomo Uji
Published: July 2022

Rare earth metals (REM) are scarce elements and are only found in the form of complex compounds of phosphate and carbonate. REM consists of 17 elements classified into light REM, medium REM, and heavy REM. This article is focused on lightweight REM, which is widely applied in various industrial fields. Many REM applications are increasing the demand for high-purity and bulk REMs. However, REM has almost the same physical and chemical properties, making it difficult to separate. Therefore, the separation of REM is interesting to study with various methods, one of which is Emulsion Liquid Membrane (ELM). ELM is developing a solvent extraction method involving three phases: the external phase, the internal phase, and the membrane phase. The key to the success of ELM lies in the stability of the emulsion, which is very dependent on the type and concentration of surfactants, so in the ELM process, it is necessary to choose the right concentration and type of surfactant. Therefore, this article was made to know the effect of surfactants such as span-80, span-85, and T154 in separating light REM using the ELM method.
Vehicular Platooning to be Secure against Cybersecurity Attacks
Authors: Mazher Noman , Brightini Alsendro , Haider Farrah
Published: July 2022

Vehicular platooning is although not a new concept yet reshaping its core idea with invovlment of autonomous driging in it. vehicle platoon is group of vehicle traveling with small space but no physical connection and negligible relative velocity with each other. Platoon can be formed from different type of vehicles such as truck, bus car etc. In platoon each vehicle has a particular role either it is a leader or follower. All of vehicle participating in platoon have to send message to their predecessor vehicle about their present location, and speed velocity. Along with other different challenges such as its trajectory , string stability , maneuvers, platoon communication suffer from security risks. Security is an essential aspects of wireless communication systems Due to the inherent transmission nature of wireless channels.There is a risk of various types of network attacks,Cyberseurity attacks are most common of them. In this research we will reveal the core idea of cybersecurity attacks in autonomous vehicle platooning.
Notes of hypopigmentation in mantled howler monkeys Alouatta palliata (Gray 1849): First documented cases of whole-body leucism from a critically endangered ecosystem in South America
Authors: Barros-Diaz Cristian , Vela Silvia , Gallo-Perez Abel , Chiquito Manuel , Cornejo Xavier , Mosquera-Muñoz Denis , Perez-Correa Julian
Published: July 2022

The existence of hypopigmentation such as leucism is the result of
inbreeding in isolated populations of wildlife and it is associated with
environmental stressors. This anomaly may reduce survival rates. Leucism
has been record in wildlife, but overall, it is considered very rare.
There have been few records of mantled howler monkeys with leucism in
Mexico and Costa Rica, but whole-body leucism in howler monkeys from
South America was unknown. In this article, we report for the first-time
documented cases of whole-body leucism in young individuals of mantled
howler monkeys Alouatta palliata in an isolated remanent of
tropical dry forest in southwestern Ecuador known as Cerro Blanco
Protective Forest. In total, we found two individuals: a juvenile female
and a juvenile male in October 2021. We also include a short report
about the observation of two seedlings of Dichapetalum (Dichapetalaceae)
showing albinism. The report of howler monkeys with whole-body leucism
may be caused by the interaction of two processes: inbreeding because of
isolated populations and air pollution with sulphur. Thus, immediate
management strategies must be considered to significantly increase
connectivity with other populations of howler monkeys and reduce air
pollution in Guayaquil. Our findings also reveal that hypopigmentation
is becoming more frequent in howler monkey´s population along its
distributional range. Therefore, we encourage the community to consider
a regional management strategy.
Duodenal diverticula perforation caused by an impacted bezoar successfully treated endoscop-ic drainage and lithotripsy: A case report and literature review
Authors: tadokoro takeshi , oishi Koichi , Namba Youske , Bekki Tomoaki , Okimoto Sho , Mukai Shoichiro , Saito Yasufumi , Fujisaki Seiji , Takahashi Mamoru , Mouri Teruo , Nishida Toshihiro , Fukuda Toshikatsu
Published: July 2022

Duodenal diverticula perforation due to an impacted bezoar is a rare
disease. Surgical treatment is associated with high rates of
complications and mortality; therefore, treatment strategies must be
carefully decided. Endoscopic treatment offers significant benefits to
patients over surgery.
Experimental Analysis and Numerical Simulation of Ignition Delay Time of Diesel Fuel Using a Shock Tube
Authors: Santana Claudio , Barros Jose
Published: July 2022

The present work consisted in developing computational routine for
prediction and characterization ignition delay time in shock tube. The
work was the development of computational routines to characterize the
shock wave parameters the ignition delay times of diesel to validate the
experimental tests carried out in shock tube conducted by Santana and
compare it with the experimental tests and numerical simulations carried
out by others authors available in the literature. A linear regression
of the experimental tests conducted by Santana et al [3] with
conventional diesel was performed to obtain the Arrhenius equation for
numerical simulation of the ignition delay time of diesel under the
following conditions: temperatures from 880 to 1300K, pressures 24 bar
and equivalence ratio 1. The results show good prediction between
experimental and simulations. Were found delay times ranging from 425 to
1890μs. Considering all temperature range, the difference between the
experimental and simulated test was approximately 15%, this difference
also can be explained by the measurement in the shock tube, that the
ignition delay time was calculated by the time difference between the
passage of the shock wave by the pressure sensor and the start of the
ignition detected by the luminosity detection sensor.
Shared histological and immunohistological findings in two patients with generalized vitiligo associated with autoimmune atrophic gastritis
Authors: Ghalamkarpour Fariba , andre muriel.cario , Gauthier Yvon
Published: July 2022

Two patients with concomitant vitiligo and autoimmune atrophic gastritis
a comparative histological study on skin and gastric mucosa were
preformed.Common findings were seen in both specimens .Down expression
of E-Cadherin and Collagen IV leading to detachment of melanocytes and
parietal cells in addition to CD8 and CD4 Infiltration were detected.
A case of hemorrhagic shock in a patient with neurofibromatosis type 1
Authors: Sakaguchi Yutaro , Okano Hiromu , Furuya Ryosuke , Miyazaki Hiroshi , Otsuka Tsuyoshi
Published: July 2022

Neurofibromatosis type 1 (NF1) is not known to cause serious vascular
complications. This report describes a 49-year-old man with NF1 who
presented to our hospital in hemorrhagic shock due to vascular leakage
within a neurofibroma tumor. Physicians should be aware that NF1 can
cause a wide variety of vascular lesions.
Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants
Authors: Lee Elliot , Park Jung-eun , Han Young-Eun , Viswanath Ambily , Gotina Lizaveta , Cho Yoonjeong , Moon Bongjin , Hwang Jin-Young , Park Woo Kyu , Yoo Seonguk , Song Chiman , Min Sun-Joon , Hwang Eun Mi , Lee Hyunbeom , Pae Ae Nim , Roh Eun Joo , Oh Soo-Jin
Published: July 2022

Background and Purpose: TREK-1 (TWIK-related potassium channel-1) is a
subunit of the two-pore domain potassium (K2p) channel and is widely
expressed in the brain. TREK-1 knockout mice were shown to have
antidepressant-like effects, providing evidence for the channel’s
potential as a therapeutic target. However, currently there is no good
pharmacological inhibitor specifically targeting TREK-1 containing K2p
channels that also displays similar antidepressant-like effects.
Experimental Approach: We sought to find selective and potent inhibitors
for TREK-1 related dimers both in vitro and in vivo. We synthesized and
evaluated 2-hydroxy-3-phenoxypropyl piperidine derivatives yielding a
library from which many TREK-1 targeting candidates emerged. Key
Results: Hydroxyl-phenyl- (2a), piperidino- (2g), and pyrrolidino- (2h)
piperidinyl substituted compounds showed high potencies to TREK-1
homodimers with significant antidepressant-like effects in forced swim
test and tail suspension test. Interestingly, these compounds were found
to have high potencies to TWIK-1/TREK-1 heterodimers, contrastingly,
difluoropiperidinyl-4-fluorophenoxy (3e) and
4-hydroxyphenyl-piperidinyl-4-fluorophenoxy (3j) compounds had high
potencies to TREK-1 homodimer but lower potency to TWIK-1/TREK-1
heterodimers without significant antidepressant-like effects. We
observed positive correlation between inhibition potency to
TWIK-1/TREK-1 and immobility time, and no correlation between inhibition
potency to TREK-1 homodimer and immobility time. This was consistent
with molecular docking simulations of selected compounds to TREK-1
homodimeric and TWIK-1/TREK-1 heterodimeric models. Existing
antidepressant fluoxetine was also found to potently inhibit
TWIK-1/TREK-1 heterodimers. Conclusion and Implications: Our study
reveals novel potent TWIK-1/TREK-1 inhibitors 2a, 2g, and 2h as
potential antidepressants and suggest that the TWIK-1/TREK-1 heterodimer
could be a potential novel molecular therapeutic target for
antidepressants.
Exposure to weak opioids and risk of gastrointestinal tract cancers: A series of nested case-control studies.
Authors: Houston Martin , McMenamin Úna , Johnston Brian , McDowell Ronald , Hughes Carmel , Murchie Peter , Cardwell Christopher
Published: July 2022

Background There is evidence gastrointestinal (GI) motility may play a
role in the development of GI cancers. Weak opioids (codeine and
dihydrocodeine) decrease GI motility, but their effect on GI cancer risk
has not been assessed. Aim To assess the association between weak
opioids and cancers of the GI tract. Methods A series of nested
case-control studies was conducted using Scottish general practice
records from the Primary Care Clinical Informatics Unit Research
database. Oesophageal (n=2,432), gastric (n=1,443), and colorectal
cancer (n=8,750) cases, diagnosed between 1999 and 2011, were identified
and matched with up to five controls. Weak opioid use was identified
from prescribing records. Odds ratios (OR) and 95% confidence intervals
(CI) were calculated using conditional logistic regression, adjusting
for relevant comorbidities and medication use. Results There was no
association between weak opioids and colorectal cancer (adjusted
OR=0.96, CI 0.90, 1.02, p=0.15). There was an increased risk of
oesophageal (adjusted OR=1.16, CI 1.04, 1.29, p=0.01) and gastric cancer
(adjusted OR=1.26, CI 1.10, 1.45, p=0.001). The associations for
oesophageal cancer, but not gastric cancer, were attenuated when weak
opioid users were compared with users of another analgesic (adjusted
OR=1.03 CI 0.86, 1.22, p=0.76 and adjusted OR=1.29 CI 1.02, 1.64, p=0.04
respectively). Conclusion In this large population-based study, there
was no consistent evidence of an association between weak opioids and
oesophageal or colorectal cancer risk, but a small increased risk of
gastric cancer. Further investigation is required to determine whether
this association is causal or reflects residual confounding or
confounding by indication.
TIGAR suppresses ER stress-induced neuronal injury through targeting ATF4-signaling in cerebral ischemia/reperfusion
Authors: Chen Lei , Tang Jie , Li Qi-Qi , Li Yan-Yan , Li Jia-Ying , Sheng Rui , Qin Zhenghong , Zheng Wen-Hua
Published: July 2022

Abstract Background and Purpose Previous studies have shown that TIGAR
(TP53-induced glycolysis and apoptosis regulator) protects against
cerebral ischemia/reperfusion injury via the improvement of the redox
and energy homeostasis of neurons. TIGAR is found in the endoplasmic
reticulum (ER) and nucleus but its role in ER stress is unclear. This
study aimed to investigate the ER and nuclear translocation of TIGAR
during ER stress and the influences of the nuclear TIGAR in cerebral
ischemia/reperfusion-induced ER stress. Experimental Approach Mice were
subjected to the middle cerebral artery occlusion/reperfusion. Cultured
neurons were treated with oxygen and glucose deprivation, tunicamycin or
thapsigargin. Key Results The increases in ATF4 target genes and ER
stress-induced neuronal apoptosis were reduced by overexpression of
TIGAR. Furthermore, increases in the localization of TIGAR and ATF4 to
the nucleus were observed after in vitro and in vivo cerebral
ischemia/reperfusion or ER stress models. The nuclear TIGAR interacts
with ATF4 and inhibits the transcription of downstream pro-apoptotic
genes of ATF4, resulting in protection against cerebral
ischemia/reperfusion injury. Intriguingly, the translocation of TIGAR to
the ER and nucleus and inhibition of the transcription of ATF4 is depend
on Q141/K145 of TIGAR instead of its phosphatase activity and
mitochondrial localization domains. Conclusion and Implications These
results suggest that TIGAR translocates to the ER and the nucleus to
interact with ATF4 after cerebral ischemia-reperfusion induced ER stress
via its Q141/K145. The study uncovered a novel neuroprotective mechanism
of TIGAR through regulating ER stress via a ATF4-mediated signaling
pathway.
Flow visualization simulation of cemented tailings backfill slurry by particle tracking technology
Authors: Sun Haikuan , Gan Deqing , Xue Zhenlin , Zhang Yajie
Published: July 2022

Pipeline flow visualization of cemented tailings backfill slurry (CTBS)
improves the safety and stability of transportation. High turbidity and
low resolution make it difficult for conventional methods to monitor the
particle distribution state of CTBS in a short period of time. Particle
tracking technology (PTT) is used to simulate and investigate the flow
characteristics of CTBS pipeline, combine with theoretical analysis to
construct a CTBS pipeline visualization model, elaborate the particle
distribution state when CTBS flows in the pipeline, and explore the
effects of pipe diameter (PD), flow velocity (FV) and tailings gradation
(TG) on the particle distribution. The results show that particle
tracking technology is better applied to investigate the particle
transport distribution characteristics of CTBS tailings. Three concepts
of particle accumulated gravity G, static
friction angle θ and diameter dividing line are defined, and the
transport pipe is divided into light wear zone, medium wear zone and
heavy wear zone. The increase in pipe diameter increases the content of
fine particles at the pipe wall and the thickness of the lubrication
layer becomes larger, which improves the safety and stability of CTBS
transport. The increased flow velocity reduces the settling phenomenon
of large size particles and improves the transport efficiency, which
increases the pipeline transport resistance. The wider the range of
tailings gradation and the smaller the ratio of the number of large size
tailings to small size tailings, the more suitable the tailings are for
pipeline transportation as a backfill aggregate.
Successful mapping and ablation of a pediatric-onset non-reentrant fascicular tachycardia
Authors: Nagatomo Yusaku , Takase Susumu , Sakamoto Kazuo , Hazumu Nagata , Yamamura Kenichiro , Hiroyuki Tsutsui , Ohga Shouichi
Published: July 2022

Non-reentrant fascicular tachycardia (NRFT) developed in a 6-year-old
Japanese boy. Because of the drug-resistant recurrences, he received
catheter mapping and ablation at age 10 years. An electrocardiogram
exhibited a superior left axis deviation, a right bundle branch
block-type configuration, and relatively narrow QRS with sharp R wave.
It suggested verapamil-sensitive ventricular tachycardia (VT), but
showed no sensitivity to verapamil or reentrant characteristics in the
electrophysiological study. Detailed VT mapping determined the earliest
presystolic Purkinje potential on the left posterior fascicle at the
mid-ventricular septum. Radiofrequency current applications to the
lesion led to his NRFT-free life without restriction for 16 months.
Infectious mononucleosis in children: clinical and laboratory criteria for assessing severity
Authors: Ikkes L. A. , Martynova G. P.
Published: July 2022

Рurpose: to identify clinical and laboratory criteria that mark the severity of infectious mononucleosis in children, with the identification of risk factors for the development of severe forms and unfavorable course.Patients and methods. A comparative prospective clinical study involved 200 children aged 3 to 11 years with moderate (125 people) and severe (75 people) form of infectious mononucleosis. When comparing clinical and laboratory data in the compared groups, the Mann-Whitney test was used. For multiple comparisons, the Kruskal-Wally test was used. Significance of differences was determined at a significance level of 0.05 (p < 0.05).Results. A comparative analysis of the clinical and laboratory manifestations of infectious mononucleosis revealed statistically significant differences in the studied parameters depending on the severity of the disease. Severe forms of infectious mononucleosis were distinguished by the most pronounced clinical symptoms, as well as changes in hematological parameters and biochemical changes. The combined etiology of infectious mononucleosis also contributed to a more severe course of the disease.Сonclusion. Timely diagnosis and assessment of the severity of the manifest form of infectious mononucleosis determine the adequacy of the appointment of rational antiviral and pathogenetic therapy, preventing the development of adverse effects and complications.
Various approaches to influence melatonin level in sheep reproduction
Authors: Kárpáti Edina , Fürlinger Dóra , Pleskó Anikó , Gulyás László , Gáspárdy András , Becskei Zsolt
Published: July 2022

A new field of research in reproductive biology was heralded by the discovery of melatonin in 1958. The concentration of melatonin follows light-dark cycles with significantly higher concentrations during darkness. The authors present the importance of the melatonin protein hormone by focusing on the reproductive processes in domestic sheep. In their literature review, they report that sheep melatonin levels show daily and seasonal rhythms. In sheep as a seasonal breeder and short-day animal species, seasonal increases in melatonin production stimulate sexual activity. The authors describe innovative possibilities for regulating melatonin levels in sheep production. The use of exogenous melatonin brings forward the expression of the sexual cycle. It increases the fertility rate, the number of lambs born, and the chances of survival of twin lambs. Melatonin is a neuroprotection compound against cerebral hypoxia and the development of inflammatory processes in the growing foetus and the newborn lamb.
Vaccine-Induced Immune Thrombotic Thrombocytopenia: Where does The PF4 Fit?
Authors: RC Costa-Filho , HC Castro-Faria Neto , MS Azevedo , AM Da-Cruz
Published: July 2022

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe and usually fatal syndrome with an aggressive thrombotic process in unusual sites (notably, sinus veins of the brain and/or splanchnic veins) that accompanies profound thrombocytopenia. If not well managed, VITT may progress to a more severe systemic disease such as disseminated intravascular coagulation. VITT was associated with two adenoviral vector vaccines, mainly ChAdOx1 nCoV-19 (AstraZeneca) and Ad26.COV2.S (Janssen/ Johnson & Johnson) was first reported in late February 2021 and mid-April 2021, respectively. This thrombotic phenomenon closely resembled that of autoimmune heparin-induced thrombocytopenia. Yet, in 2021, the MHRA (Medicines & Healthcare products Regulatory Agency) and the European Medicines Agency (EMA) claim no association between thrombosis and vaccines. Not long after, three scientific societies from Norway, Germany, and the UK reported in the press and social media the detection of thrombocytopenia with cerebral venous sinus thrombosis (CVST) and anti-platelet factor 4 (anti-PF4) antibodies in patients succeeding adenovirus-based vaccination. The immune response against PF4; (also known as CXCL4) in VITT is probably triggered by the proinflammatory milieu; compounds such as human cell-line proteins, non-assembled adenoviral proteins, and potentially EDTA (edetic acid) could be contributing to the prothrombotic state. This review will address functional aspects of PF4 in the thromboinflammatory phenomena, its role in the current anti-SARS-CoV-2 adenoviral-based vaccines, and evidence for its role in triggering VITT. Physicians as well as the public need to be aware of this new disease to quickly provide accurate diagnosis and timely treatment.