bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Usaha UMKM Sektor Kuliner Melalui Digital Marketing di Kota Mataram
Authors: Suryati Desi , Amini Rohmiati , Widyaningrum Meiyanti , Samsuriadi Samsuriadi
Published: May 2024

Penelitian dengan judul Pengembangan Usaha UMKM sektor kuliner melalui Digital Marketing di Kota Mataram merupakan penelitian yang diangkat dari fenomenana maraknya penggunaan digital marketing dalam kegiatan pemasaran yang dilakukan oleh usaha usaha mikro seperti UMKM di Kota Mataram. Selain itu penggunaan digital marketing juga bisa memberikan dampak terhadap besar kecilnya penjualan yang dihasilkan para pelaku usaha. Maraknya penggunaan digital marketing ini dilatar belakangi oleh kemampuan transaksi jual beli mayarakat yang serba terbatas pada masa pandemi covid 19 dua tahun yang lalu. Pola pemasaran seperti ini terus berlanjut hingga saat ini yang menyebabkan perlu dlakukan kajian dan penelitian untuk melihat keberlanjutan dari penggunaan digital marketing bagi pengembangan usaha UMKM di Kota Mataram.
Metode pengumpulan data yang digunakan adalah Penelitian ini menggunakan metode pendekatan kualitatif. Yang dilakukan dalam beberapa tahapan hingga mencapai sebuah rancangan yang bisa menjadi acuan dalam penggunaan Digital Marketing. Alur penelitian yang dilakukan untuk bisa dikembangkan lebih lanjut. Tahap tahap mencakup tahap analisis, desain, implementasi dan testing.
Hasil penelitian ini diharapkan bisa memberikan manfaat bagi pengembangan usaha UMKM di Kota Mataram khususnya dan perekonomian NTB pada umumnya sehingga bisa lebih lanjut mengembangkan perekonomian dengan melanjutkan pola penerapan Digital marketing ini atau bisa ditemukan pola baru dalam pengembangan UMKM di Kota Mataram. Produk digital marketing yang dikembangkan sebagai alternative solusi yang ditawarkan kepada mitra tergolong sederhana dan user friendly, hal tersebut untuk mempermudah UMKM untuk menggunakan digital marketing yang dibangun mengingat SDM pada setiap UMKM tergolong gagap teknologi (gaptek). Dan apabila, UMKM terus menggunakan produk digital marketing yang dibangun secara berkelanjutan, akan meningkatnya pengetahuan mitra mengenai teknologi digital marketing, dan akan berpengaruh pada meningkatnya jangkauan sebar pemasaran produk mitra menjadi lebih luas sehingga penjualan akan ikut meningkat, dan berdampak kepada profit yang lebih tinggi.
Pengaruh Kualitas Pelayanan Terhadap Kepuasan Nasabah Pada Bank CIMB Niaga Cabang Mataram
Authors: Solatiyah Baiq
Published: May 2024

The purpose of this study was to examine the effect of service quality, namely tagible, empathy, reliability, responsiveness and assurance on customer satisfaction at Bank CIMB Niaga Mataram Branch. The sampling technique used purvosive sampling and obtained 50 customers. Data analysis techniques use the classic assumption test and hypothesis testing. The results of the study using the t test show that partially the responsiveness and assurance variables have a significant effect on customer satisfaction. While the variables of tangibles, emphaty and reliability partially have no effect on customer satisfaction. The results of testing the hypothesis using the F test show that the variables of tangibles, emphaty, reliability, responsiveness, and assurance simultaneously affect customer satisfaction.
ANALISIS KELAYAKAN BISNIS LIKE MIE AND COFFEE DI BATANG
Authors: Alfiesyah Emilia
Published: May 2024

Marketing mix is a collection of marketing variables that are carried out in an integrated manner or a marketing strategy that is carried out simultaneously by the company to pursue the desired sales target in the target market. The research method used in this study uses a qualitative descriptive method. The variables used by Like Mie and Coffee companies include product, place, price, and promotion. The materials used in the manufacture of products are of good quality. It has a strategic and instagramable place. The prices offered are very affordable and provide lots of discounts. In promoting its products using print media and social media, Like Mie and Coffee is a business that deserves to be developed from all aspects that have been carried out by the company. Apart from that, establishing a second branch in Semarang is proof that the business is very feasible to develop.
Sistem Bagi Hasil Pada Penggarapan Lahan Pertanian Terhadap Peningkatan Pendapatan Petani Di Desa Bagik Polak Kecamatan Labuapi Kabupaten Lombok Barat
Authors: Apriani Sindi , Taqiuddin Habibul Umam , Yakub Muhammad
Published: May 2024

The practice of muzara'ah is one of the economic activities that is often carried out by Muslim communities in particular. However, not many ordinary people know how to share the results of their collaboration. This research is motivated by the agricultural sector which is the livelihood of the majority of people. In the agricultural sector, they are divided into farmers who own the land and farmers who work on the land. Between land owners and farmers who work on their land, they enter into a production sharing agreement called a Muzara`ah contract. The aim of the Muzara`ah contract is to improve the welfare of land-owning farmers and sharecroppers.
 In this research, researchers used qualitative methods. The data collection techniques in this research are observation, interviews and documentation. Meanwhile, the data analysis techniques used in this research are data reduction, data display, and drawing conclusions.
The results of this research show that 1) the concept of profit sharing in Bagik Polak Village, Labuapi District, West Lombok Regency uses a muzar'ah agreement which is carried out based on an oral agreement to share profits between the two parties with a percentage equal to the profit sharing between the land owner and the land chooser, namely for crops. paddy. The profit share is ½ : ½, while for vegetable crops the profit share is 1/3, ½. 2) The muzara'ah agreement has an influence on improving the welfare of both land owners and cultivators in Bagik Polak Village, Labuapi District, West Lombok Regency, where the primary health needs and needs of land owners and their families are met and basic primary health needs are met. The needs of sharecroppers are met in the form of clothing and shelter for their families
Strategi Pengembangan Pariwisata Halal Taman Surga Rinjani Desa Sembalun Bumbung Kecamatan Sembalun Kabupaten Lombok Timur
Authors: Hasbiatun Hasbiatun , Taqiuddin Habibul Umam , Yakub Muhammad
Published: May 2024

Tourism development which is currently becoming a trend in several countries in the world, including Indonesia, is the development of sharia tourism or what is better known as halal tourism. The development of halal tourism in Rinjani Paradise Park, Sembalun Bumbung Village, Sembalun District, has not yet been seen and has not been fully campaigned to the community. Based on this, the formulation of the problem in this research is: 1) what is the strategy for developing Halal Tourism in Taman Surga Rinjani, Sembalun Bumbung Village, Sembalun District? ?. The aims of this research are: 1. To analyze the Halal Tourism development strategy at Rinjani Paradise Park, Sembalun Bumbung Village, Sembalun District. 2. To analyze the influence of the Halal Tourism development strategy at Rinjani Paradise Park on the economy of the people of Sembalun Bumbung Village, Sembalun District.
This type of research is descriptive research. The research design in this study uses qualitative research methods. The data collection techniques in this research are observation, interviews and documentation. Meanwhile, the data analysis techniques used in this research are data reduction, data display, and drawing conclusions.
The results of this research show that: 1. The strategy for developing Halal tourism in Rinjani Paradise Park is to promote it both offline by distributing it using brochures and online using social media platforms. 2. The existence of Rinjani Paradise Park tourism has an influence on the economic development of the Sembalun Bumbung Village community where the unemployment rate is reduced and the growth of MSMEs around the Sembalun Bumbung areaStrategy
Molecular identification using DNA barcoding and pharmacognostical evaluation of Justicia beddomei (C. B. Clarke) Bennet
Authors: Rajeswariammal Nagalekshmi , Palaniappan Senthilkumar
Published: May 2024

Justicia beddomei (C.B. Clarke) Bennet has been utilized for many years in the traditional medical system. This study aimed to facilitate the identification of J. beddomei (C.B. Clarke) Bennet using trnH–psbA DNA barcode region, NCBI database, and pharmacognostical features of the plant parts. Genomic DNA was extracted from plant leaf samples and polymerase chain reaction amplification and DNA sequence determination were performed. The contigs DNA sequence 319 bp was analyzed using the similarity basic search method BLASTn. The trnH– psbA barcode region of 319 bp contigs sequence showed 100% similarity with the standard sequence of J. beddomei with the Accession No. MK347214.1 from the NCBI database. Microscopical studies of the different parts of the plant facilitate the identification and differentiation of J. beddomei from its morphologically similar and confusing plant Justicia adhatoda L. Justicia beddomei can be easily identified by the flower and its inflorescence arrangement. The other identification features are the presence of cystoliths in the mesophyll region of the leaf, and the presence of colored content and crystals in the powder microscopic analysis. The outcome of the present detailed microscopic study of the stem, leaf, and flower of J. beddomei is of great value in the identification of the powdered samples and their adulterants.
Action research and professional development in schools
Authors: Støren Kristin
Published: May 2024

This article examines practitioner action research in schools and how action research can enhance practice and generate knowledge through partnerships between academia and the education sector. In 2020, revisions to the Norwegian curriculum for primary and secondary education introduced guidelines for professional work. The changes in the curriculum framework entail teachers’ collaboration in knowledge production - utilizing research and their own experiences in the process. This changed the formal role of teachers from transmitting established knowledge to producing knowledge in professional development and research activities. The new regulations can be related to traditions within practitioner action research.
The article explores how action research can be used as a methodological framework in the professional work of schools. The starting point for the article is a thematic analysis of reflections from an action research project named Deeper Learning – How?, in which six schools participate in developing a model for unit planning. Structured interviews were conducted with members of school development groups in the schools every six months over 3.5 years, totaling seven interviews per school. The participants' reflections on their professional work serve as the empirical basis for the article.
Results from the thematic analysis demonstrate that participants employed the action research process as a methodological tool to cultivate new insights and enhance practice. These reflections enrich the schools' comprehension of their educational practices and lead to measures for improvements, actions, and change. The results also highlight that proactive leadership, agreed-upon measures, teamwork, and a consistent rhythm in professional work are vital for educational practice development and knowledge production.
Effects of extreme meteorological factors and high air pollutant concentrations on the incidence of hand, foot and mouth disease in Jining, China
Authors: Cao Haoyue , Xu Rongrong , Liang Yongmei , Li Qinglin , Jiang Wenguo , Jin Yudi , Wang Wenjun , Yuan Juxiang
Published: May 2024

Background

The evidence on the effects of extreme meteorological conditions and high air pollution levels on incidence of hand, foot and mouth disease (HFMD) is limited. Moreover, results of the available studies are inconsistent. Further investigations are imperative to elucidate the specific issue.

Methods

Data on the daily cases of HFMD, meteorological factors and air pollution were obtained from 2017 to 2022 in Jining City. We employed distributed lag nonlinear model (DLNM) incorporated with Poisson regression to explore the impacts of extreme meteorological conditions and air pollution on HFMD incidence.

Results

We found that there were nonlinear relationships between temperature, wind speed, PM2.5, SO2, O3 and HFMD. The cumulative risk of extreme high temperature was higher at the 95th percentile (P95th) than at the 90th percentile(P90th), and the RR values for both reached their maximum at 10-day lag (P95th RR = 1.880 (1.261–2.804), P90th RR = 1.787 (1.244–2.569)), the hazardous effect of extreme low temperatures on HFMD is faster than that of extreme high temperatures. The cumulative effect of extreme low wind speeds reached its maximum at 14-day lag (P95th RR = 1.702 (1.389-2.085), P90th RR = 1.498(1.283–1.750)). The cumulative effect of PM2.5 concentration at the P90th was largest at 14-day lag (RR = 1.637 (1.069–2.506)), and the cumulative effect at the P95th was largest at 10-day lag (RR = 1.569 (1.021–2.411)). High SO2 concentration at the P95th at 14-day lag was associated with higher risk for HFMD (RR: 1.425 (1.001–2.030)).

Conclusion

Our findings suggest that high temperature, low wind speed, and high concentrations of PM2.5 and SO2 are associated with an increased risk of HFMD. This study not only adds insights to the understanding of the impact of extreme meteorological conditions and high levels of air pollutants on HFMD incidence but also holds practical significance for the development and enhancement of an early warning system for HFMD.
Comparative Evaluation of Contact Angle in Biosynthesised and Chemically Synthesised Silver Nanoparticle-based Root Canal Irrigants: An In-vitro Study
Authors: Chandran Neena , Ramesh Sindhu , Adarsh VJ , Rakesh VKP
Published: May 2024

Introduction: Irrigating solutions are vital in endodontics, serving to meticulously disinfect root canals, enzymatically dissolve pulpal remnants, and facilitate thorough flushing to eradicate microorganisms. This intricate process ensures optimal microbial control, tissue dissolution, and debris removal, contributing to enhanced endodontic outcomes and overall oral health in clinical practice. Aim: To evaluate the contact angle of Trisodium Citrate (TSC) Silver Nanoparticles (AgNP) and Biosynthesised AgNPs when used in root canal irrigation. Materials and Methods: This in-vitro study was conducted at White Lab, Department of Conservative Dentistry and Endodontics, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences Saveetha University, Chennai, Tamilnadu, India, from January 2023 to August 2023. A total of 40 single-rooted dentine samples extracted from human teeth were utilised. Ethical clearance was duly obtained. The samples were categorised into four groups (n=10 each). The groups underwent distinct irrigation processes, including Biosynthesised AgNPs from Azadirachta Indica (Group-1), Chemically synthesised AgNPs from Trisodium citrate (Group-2), 5.25% Sodium Hypochlorite (Group-3), and Distilled Water (DW) as the control (Group-4). The contact angle of the tested irrigants was thoroughly evaluated in all the samples using an Ossila goniometer. The data were analysed using Statistical Package for Social Sciences (SPSS) 21.0. Statistical tests used were Analysis of Variance (ANOVA). A p-value of <0.05 was considered statistically significant. Results: Group-1 and Group-2 showed significantly low contact angles (p=0.002) compared to the other irrigants like 5.25% Sodium Hypochlorite (NaOCl) and water used as control. There was no statistically significant difference among the tested irrigants, with TSC AgNPs and A. Indica AgNPs showing the best results followed by NaOCl and distilled water. Conclusion: The AgNPs in prepared root canals can serve as a good alternative as an irrigating solution. Biosynthesised AgNPs are equivalent to Trisodium citrate AgNPs in regard to wettability.
Methods of Assigning Labels to Detect Outliers
Authors: Kirti Shashank , Pandey Rajeev
Published: May 2024

Outlier identification is a crucial field within data mining that focuses on identifying data points that significantly depart from other patterns in the data. Outlier identification may be categorized into formal and informal procedures. This article discusses informal approaches, sometimes known as labelling methods. The study focused on the analysis of real-time medical data to identify outliers using outlier labelling techniques. Various labelling approaches are used to calculate realistic situations in the dataset. Ultimately, using the anticipated outcomes of the outliers is a more suitable approach for addressing the needs of the larger populations.
Antioxidant Activity of Ethyl Acetate Extract from Endohytic Bacteria of Mangosteen (Garcinia mangostana L.) Roots
Authors: Nova Bastian , Wardi Epi Supri , Afrianti Ria , Maihendra Aldo
Published: May 2024

Aims: This study aims to obtain isolates of endophytic bacteria found in mangosteen roots, determine information regarding the chemical contents of secondary metabolites from endophytic bacteria, and obtain antioxidant activity data using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method.
Place and Duration of Study: The research was conducted from June to September 2019 at the Microbiology Laboratory of Universitas Perintis and the Higher Education Coordinating Board Region X, West Sumatra, Indonesia.
Methodology: Isolation of endophytic bacteria, secondary metabolite production by endophytic bacteria, phytochemical screening, and antioxidant activity testing using the DPPH method.
Results: The results of measuring the antioxidant activity of secondary metabolite extracts from endophytic bacteria of mangosteen rootsusing the DPPH method yielded an IC50 of 14,047.912 g/ml and gallic acid solution of 2,498 g/ml. Furthermore, the T-test analysis between the % inhibition of secondary metabolites from endophytic bacteria of mangosteen roots and gallic acid yielded a significant value of 0.013.
Conclusion: The antioxidant activity of secondary metabolites from endophytic bacteria of mangosteen roots is considered weak and cannot be an alternative or solution for antioxidant production.
Assessment of Cefuroxime and Cefuroxime Clavulanic Acid Prescription Practices for Infection Management in Routine Indian Healthcare Settings: Expert Insights
Authors: Manjula S  , Krishna Kumar M
Published: May 2024

Background: Cefuroxime axetil has shown effectiveness as part of intravenous/oral sequential therapy for community-acquired pneumonia (CAP) treatment, although some countries currently lack dosage recommendations for this regimen. In addition, the perspectives of clinicians were not studied.  So, this study evaluated the prescription practice of cefuroxime, and cefuroxime+ clavulanic acid in the management of infections in routine Indian settings.
Methods: The cross-sectional survey, titled ‘Cefuroxime & Cefuroxime+Clavulanic acid in Management of Infections: Expert Perspective (CARE) Study’, utilized a 20-item, multiple-response questionnaire to gather expert opinion from specialists regarding the clinical use of cefuroxime and cefuroxime + clavulanic acid in managing infections. The survey encompassed questions about current prescription practices, clinical observations, preferences, and experiences related to the use of these antibiotics in routine settings.
Results: Among the 164 clinicians surveyed, 78% of the respondents indicated that cefuroxime was highly effective in managing lower respiratory tract infections. Additionally, 91% of the experts stated that the combination of cefuroxime and clavulanic acid was very effective in managing infections. The majority of clinicians recommended cefuroxime + clavulanic acid as the initial therapy for complicated urinary tract infections (88%), as well as first-line therapy for uncomplicated skin and soft tissue infections (45%) and community-acquired pneumonia (58%). According to 40% of the clinicians, cefuroxime + clavulanic acid was recommended as the initial therapy for 21-30% of patients suspected of methicillin-resistant Staphylococcus aureus infection. Most respondents (88%) preferred cefuroxime + clavulanic acid as the antibiotic for managing Pseudomonas aeruginosa infection.
Conclusion: The survey has emphasized the critical role of cefuroxime and cefuroxime + clavulanic acid as antibiotics in managing diverse infections. Clinicians' recognition of their efficacy and preference for combination therapy has underscored the importance of antibiotic stewardship in optimizing patient care.
Integration of Customized Wheelchair Tracking and Durable Medical Equipment's Solutions for Hospitals: A Continuous Quality Improvement Project
Authors: Owolabi Anuoluwapo
Published: May 2024

Aim: The purpose of the project is to design a model that will reduce the number of missing wheelchairs in the National Institutes of Health (NIH) Clinical Center; this will be achieved by designing a process to improve the tracking of wheelchairs at the clinical center.
Study Design: Qualitative.
Place and Duration of Study: National Institutes of Health (NIH) Clinical Center between 2017 and 2018.
Methodology: A process flow diagram was designed to study the current process and identify areas of opportunities. Ten in-depth interviews were conducted with diverse staff, including nurses and patient escorts, to identify system inefficiencies and barriers. Stakeholders were chosen for their roles and experience, enriching the root cause analysis. A fishbone diagram was constructed to ascertain the flow and direction of the problem being investigated.
Results: The study found that investing in Stryker TC wheelchairs significantly reduced the rate of missing wheelchairs at the NIH Clinical Center from 50% to 20% monthly. This resulted in substantial operational cost savings. The hospital saved approximately $200,000 annually in 2017 alone by reducing the need to replace missing wheelchairs, which cost $5,000 per unit. It was a good management decision to invest in Stryker TC wheelchairs that reduced the rate of missing wheelchairs from an average of 50% to an average of 20% monthly.
Conclusion: The study shows that investing in Stryker TC wheelchairs significantly reduced missing wheelchairs from 50% to 20% monthly. This led to $200,000 in annual savings by decreasing the need for replacements. Although the initial cost is high, the long-term savings justify the investment. The findings suggest that healthcare administrators should consider similar investments to enhance care delivery and operational excellence. This research highlights the effectiveness of innovative solutions in addressing logistical challenges in healthcare settings, facilitating more efficient patient care industry-wide.
Groundwater Marketing Dynamics in Northern Dry Zone Farms of Karnataka: A Comparative Study (2006 to 2021)
Authors: Yamuna N  , Nayak Mahantesh R , Rakesh N
Published: May 2024

Groundwater is an essential resource, but it is becoming increasingly scarce and depleting rapidly, particularly in Karnataka. As a result, groundwater markets have emerged as an alternative strategy to manage this limited resource more efficiently and equitably. These markets enable farmers who cannot afford water extraction machinery to access irrigation. This article, aims to study present status of groundwater markets, temporal depletion of water table, groundwater security, economics and factors affecting water trade in Northern Dry Zone of Karnataka, mainly to compare with the results obtained in the past study [1] to analyze changes in scenario and have historical lessons. Multi-stage random sampling technique was used to select farmers, who were then categorized into water sellers, self-users, and buyers. Primary data was collected through a structured, pre-tested schedule and analysed using descriptive and logit regression analysis. Results show that unlike earlier study, buyers in present study owned wells. Depth of borewells has increased (overall 44%), resulting in increased drilling, deepening, and pumping costs. Very few farmers (8%) acknowledged over-extraction from their farms could also contribute to groundwater insecurity. While studying economics it was found that perennial crops had the highest economic rents (260, 610Rs/hr for sellers and buyers).Reason for participation in water market has shifted from no investment capacity to water scarcity compared to earlier study. So farmers could be motivated to participate in water markets instead of relying on new wells during water shortages to encourage optimal water use and reduce negative externalities like increasing wells.
Studies on Heterozsis Breeding in Brinjal Germplasm for Growth and Yield Traits, Solanum melongena L.
Authors: Kanchana R. , Vijayalatha K.R. , Sandeep G. , Sidhdharth G.
Published: May 2024

Brinjal, Solanum melongena L. is one of the commercial annual vegetables grown all over India for its edible fruits. Heterosis in vegetable crops helps to exploit the superior hybrids based on its phenotypic superiority over their parents and indicates predominance of non-additive genetic effects. This research was carried out at Department of Vegetable Science, Horticultural College and Research Institute, Periyakulam. The study involves six parents and thirty hybrids laid out in Randomised Block Design with two replications. The cross CO2 × Kothampatti Kathiri, obtained significant positive heterosis (16.53%) for plant height over better parent. Significant heterosis over mid parent was observed for number of branches in Kothampatti Kathiri × Odavai Pachai Kathiri, 33.33%, fruit width in Dharmapuri Oodha Kathiri × Poiyur Purple Kathiri, 25.54%, fruit length in Kothampatti Kathiri × Gobi Pachai Kathiri, 24.33%. Significant negative heterosis over better parent for number of days to 50% flowering was observed in the cross Odavai Pachai Kathiri × Gobi Pachai Kathiri, -9.25%. Significant positive heterosis over standard check was obtained for number of fruit per plant, 35.42% in the cross Dharmapuri Oodha Kathiri × CO2 and fruit yield per plant in Dharmapuri Oodha Kathiri × Odavai Pachai Kathiri, 21.54%. Heterosis exploited could be utilized in further crop improvement program in the development of a superior hybrid.
Effect of Organic Nutrient Management on Growth and Yield of Foxtail Millet
Authors: Chandana Tharala. , Kumar Prateek , Mehera Biswarup
Published: May 2024

The field experiment was conducted during ZAID (Summer) season of 2023 at Crop Research Farm, Department of Agronomy. The treatments consisting of three different organic manures Viz., FYM- 8 t/ha, Vermicompost- 2.5 t/ha, Poultry manure- 1.3 t/ha and three different liquid Organic manures viz Vermiwash - 5%, Panchagavya - 3%, Jeevamrutha- 500 l/ha. The experiment was laid out in Randomized block design 10 treatments each replicated thrice. Application of Vermicompost- 2.5 t/ha + Panchagavya - 3% (Treatment 5) recorded highest plant height (71.00 cm), maximum plant dry weight (5.54 g), maximum number of tillers/ hill (6.67), length of ears (8.67 cm), number of grains/ear (295.67), test weight (3.37 g), grain yield (1.40 t/ha), straw yield (2.73 t/ha) were recorded in treatment Maximum gross return (INR 78,200.00), net return (INR 53.002.00) and B:C ratio (2.10) were also recorded in same treatment.
The Indiscriminate Use of Pesticides could Increase the Prevalence of Alzheimer's Disease? A Systematic Review
Authors: Trevisan Kaynara , Cristina-Pereira Renata , Santos Breno Régis , Mendonça Paulo Eduardo , Silva Heberson Teixeira da , Gonçalves-Mendes Maria Tereza , Aversi-Ferreira Tales Alexandre
Published: May 2024

Aims: This review aims to perform an extensive literature search about the pesticides problems and to associate with AD in qualitative analysis, mainly.
Place and Duration of Study: Biomathematics Laboratory, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Brazil. Entre outubro de 2023 a abril de 2024.
Methodology: For the purpose of this systematic review, articles from 2014 onwards with the descriptors Alzheimer's disease and pesticides; neurodegenerative diseases and pesticides, were sought. Among these, articles considered most pertinent to the objective of the present review were utilized, i.e., those whose subject matter was associated with the effects of pesticides, especially glyphosate, on dementias, particularly Alzheimer’s disease (AD).
Results: After analyzed 35,590 articles, and applying exclusion criteria to journals with an impact factor equal to or lower than 4 and including topics most relevant to the objectives of this work, 35,526 articles were excluded, resulting in 64 remaining articles, of which 40 were qualitative in scope and 24 were quantitative. The articles considered most suitable for the objective of the present review were utilized, i.e., those whose topic was associated with the effects of pesticides, especially glyphosate, on dementia. The criteria for scrutinizing articles included a journal impact factor equal to or greater than 4 and the removal of duplicate articles using the freely accessible EndNote program from Web of Science. Articles and books on history and those outside the scope of the pesticide/AD relationship did not follow the criterion of having an impact factor equal to or greater than 4.
Conclusion: There appears to be a relationship between the increase in pesticide use, particularly Glyphosate, and the rise in Alzheimer's disease prevalence.
Non‐Corrosive, Non‐Absorbing Organic Redox Couple for Dye‐Sensitized Solar Cells
Authors: Li Dongmei , Li Hong , Luo Yanhong , Li Kexin , Meng Qingbo , Armand Michel , Chen Liquan
Published: August 2010

A new colorless electrolyte containing an organic redox couple, tetramethylthiourea (TMTU) and its oxidized dimer tetramethylformaminium disulfide dication ([TMFDS]2+), is applied to dye‐sensitized solar cells (DSCs). Advantages of this redox couple include its non‐corrosive nature, low cost, and easy handling. More impressively, it operates well with carbon electrodes. The DSCs fabricated with a lab‐made HCS‐CB carbon counter‐electrode can present up to 3.1% power conversion efficiency under AM 1.5 illumination of 100 mW·cm−2 and 4.5% under weaker light intensities. This result distinctly outperforms the identical DSCs with a Pt electrode. Corrosive experiments reveal that Al and stainless steel (SS) sheets are stable in the [TMFDS]2+/TMTU‐based electrolyte. Its electrochemical impedance spectrum (EIS) is used to evaluate the influence of different counter‐electrodes on the cell performance, and preliminary investigations reveal that carbon electrodes with large surface areas and ideal corrosion‐inertness toward the sulfur‐containing [TMFDS]2+/TMTU redox couple exhibit promise for application in iodine‐free DSCs.
Mikrofluidik in der anorganischen Chemie
Authors: Abou‐Hassan Ali , Sandre Olivier , Cabuil Valérie
Published: August 2010

In den letzten Jahren hat die Mikrofluidik in der Chemie stark an Bedeutung gewonnen. Miniaturisierte chemische Vorrichtungen ermöglichen einen kontrollierten Flüssigkeitstransport und schnelle chemische Reaktionen und sind darüber hinaus Kosten sparend, wenn man sie mit konventionellen Reaktoren vergleicht. Sowohl in der (Bio‐)Analytik als auch in der organischen Synthese werden diese Vorteile bereits ausgiebig genutzt, weniger hingegen in der anorganische Chemie und den Materialwissenschaften. Dennoch wird diese Thematik auch in der Anorganik bei der Entwicklung von Mikroreaktoren für die Trennung und selektive Extraktion von Metallionen gestreift. Bei Funktionsmaterialien wird die Mikrofluidik hauptsächlich für Verbesserungen in der Synthese von Nanopartikeln (besonders von Metall‐, Metalloxid‐ und Halbleiternanopartikeln) eingesetzt. Mikrofluidiktechniken können auch für die Entwicklung von komplizierteren anorganischen (Hybrid‐)Materialien genutzt werden.
Porenwasserdruckakkumulation bei zyklisch horizontal belasteten Monopiles mit großen Durchmessern
Authors: Taşan H. Ercan , Rackwitz Frank , Savidis Stavros
Published: August 2010

Monopiles mit Durchmessern von bis zu 8 m werden als eine geeignete Gründungsmöglichkeit für Offshore‐Windenergieanlagen (OWEA) in bis zu 40 m Wassertiefe angesehen. Durch die zyklischen Horizontalbelastungen, insbesondere aus Wind und Wellengang, finden Porenwasserdruckakkumulationen im Boden statt, die bei der Dimensionierung der Monopiles derzeit nicht berücksichtigt werden.

In diesem Beitrag wird das Verhalten der Monopiles von OWEA mit Fokussierung auf die Porenwasserdruckentwicklung für das Bemessungsszenario Extrembedingungen mittels numerischer Berechnungen untersucht. In den FE‐Berechnungen wird ein Zwei‐Phasen‐Modell in Verbindung mit einem hypoplastischen Stoffgesetz für den wassergesättigten Sandboden verwendet. Es werden die Ergebnisse von Parameterstudien präsentiert, die eine Variation von Belastungsamplitude, ‐frequenz, ‐zyklenanzahl und ‐typ, Lagerungsdichte und Durchlässigkeitsbeiwert des Sandes sowie den Durchmesser des Monopiles umfassen.

Die eigenen Ergebnisse werden den in der Literatur vorhandenen Berechnungsansätzen zur Abschätzung des Verhaltens von zyklisch horizontal belasteten Monopiles gegenübergestellt. Es wird der Einfluss von Porenwasserdruckakkumulationen auf das interaktive Trag‐ und Verformungsverhalten des Monopile‐Boden‐Systems beurteilt und die Relevanz für die Bemessungspraxis aufgezeigt.

Pore water pressure accumulation due to cyclic horizontally loaded monopiles with large diameters. Monopiles, i. e. single piles with large diameter of up to 8 m, are suitable foundations for off shore‐wind power plants built in up to 40 m water depth. Cyclic loading of the monopile‐soil system induced by extremely strong wind and water waves causes a change in pore water pressure. Current design practice does not account for such effects. In this paper the interaction behaviour of monopile‐soil systems subjected to extreme loading is analyzed using a finite element model. A fully coupled two‐phase model and a hypoplastic constitutive model for the sandy soil are used in the numerical analyses. Results from the numerical studies are presented and they include the variation of loading amplitude, frequency, number of cycles and loading type as well, initial density and permeability of the sand as well as the diameter of the monopile.

The own numerical results are compared with design equations for cyclic horizontally loaded piles from other references. Based on these investigations the importance and relevance of the consideration of pore water pressure accumulation with monopilesoil systems subjected to offshore loading conditions is demonstrated.
Zur Berechnung von Holz‐Beton‐Verbundträgern mit Methoden der mathematischen Optimierung
Authors: Rautenstrauch Karl , Raue Erich , Timmler Hans‐Georg , Schröter Hendrik , Simon Antje
Published: August 2010

Holz‐Beton‐Verbundkonstruktionen weisen als hybride Tragwerke gegenüber reinen Holz‐ bzw. Stahlbetonkonstruktionen zahlreiche Vorteile auf. Wesentlich für die Effizienz der Hybridbauweise ist die Ausbildung der Verbundfuge. Der vorliegende Beitrag stellt ein neues Verbundelement für Straßenbrücken in Holz‐Beton‐Verbundbauweise vor, welches im Rahmen eines Forschungsprojekts an der Bauhaus‐Universität Weimar entwickelt wurde. Die rechnerische Analyse der Verbundkonstruktion erfolgt — abweichend von den im Hybridbau bisher üblichen Berechnungsmethoden — unter Anwendung von Energiemethoden und Nutzung von Algorithmen der mathematischen Optimierung.

Calculation of timber‐concrete composite structures using mathematical optimization methods. Timber‐concrete composite structures have many advantages over conventional timber and re inforced concrete structures. The efficiency of such hybrid structures significantly depends on the properties of the com posite joint. This article presents a novel structural element for the joint of timber‐concrete composite bridges, which was developed as part of a research project at the Bauhaus‐Universität Weimar. In contrast to standard calculation methods, an energy method and the mathematical optimization is applied for the numerical analysis of the hybrid structure.
A research‐inspired laboratory sequence investigating acquired drug resistance
Authors: Taylor Elizabeth Vogel , Fortune Jennifer A. , Drennan Catherine L.
Published: August 2010

Here, we present a six‐session laboratory exercise designed to introduce students to standard biochemical techniques in the context of investigating a high impact research topic, acquired resistance to the cancer drug Gleevec. Students express a Gleevec‐resistant mutant of the Abelson tyrosine kinase domain, the active domain of an oncogenic protein implicated in chronic myelogenous leukemia, and investigate the kinase activity of wild type and mutant enzyme in the presence of two cancer drugs. Techniques covered include protein expression, purification, and gel analysis, kinase activity assays, and protein structure viewing. The exercises provide students with a hands‐on understanding of the impact of biochemistry on human health, and demonstrate their potential as the next generation of investigators.
A series of molecular dynamics and homology modeling computer labs for an undergraduate molecular modeling course
Authors: Elmore Donald E. , Guayasamin Ryann C. , Kieffer Madeleine E.
Published: August 2010

As computational modeling plays an increasingly central role in biochemical research, it is important to provide students with exposure to common modeling methods in their undergraduate curriculum. This article describes a series of computer labs designed to introduce undergraduate students to energy minimization, molecular dynamics simulations, and homology modeling. These labs were created as part of a one‐semester course on the molecular modeling of biochemical systems. Students who completed these activities felt that they were an effective component of the course, reporting improved comfort with the conceptual background and practical implementation of the computational methods. Although created as a component of a larger course, these activities could be readily adapted for a variety of other educational contexts. As well, all of these labs utilize software that is freely available in an academic environment and can be run on fairly common computer hardware, making them accessible to teaching environments without extensive computational resources.
Cation transport coupled to ATP hydrolysis by the (Na, K)‐ATPase
Authors: Leone Francisco A. , Furriel Rosa P. M. , McNamara John C. , Horisberger Jean D. , Borin Ivana A.
Published: August 2010

An Adobe® animation is presented for use in undergraduate Biochemistry courses, illustrating the mechanism of Na+ and K+ translocation coupled to ATP hydrolysis by the (Na, K)‐ATPase, a P2c‐type ATPase, or ATP‐powered ion pump that actively translocates cations across plasma membranes. The enzyme is also known as an E1/E2‐ATPase as it undergoes conformational changes between the E1 and E2 forms during the pumping cycle, altering the affinity and accessibility of the transmembrane ion‐binding sites. The animation is based on Horisberger's scheme that incorporates the most recent significant findings to have improved our understanding of the (Na, K)‐ATPase structure–function relationship. The movements of the various domains within the (Na, K)‐ATPase α‐subunit illustrate the conformational changes that occur during Na+ and K+ translocation across the membrane and emphasize involvement of the actuator, nucleotide, and phosphorylation domains, that is, the “core engine” of the pump, with respect to ATP binding, cation transport, and ADP and Pi release.
Isoelectric point, electric charge, and nomenclature of the acid–base residues of proteins
Authors: Maldonado Andrés A. , Ribeiro João M. , Sillero Antonio
Published: August 2010

The main object of this work is to present the pedagogical usefulness of the theoretical methods, developed in this laboratory, for the determination of the isoelectric point (pI) and the net electric charge of proteins together with some comments on the naming of the acid‐base residues of proteins
Problem‐based test: An in vitro experiment to analyze the genetic code
Authors: Szeberényi József
Published: August 2010

Terms to be familiar with before you start to solve the test: genetic code, translation, synthetic polynucleotide, leucine, serine, filter precipitation, radioactivity measurement, template, mRNA, tRNA, rRNA, aminoacyl‐tRNA synthesis, ribosomes, degeneration of the code, wobble, initiation, and elongation of protein synthesis, initiation codon
ChemInform Abstract: Observation of Uniaxial Structures of Underpotentially Deposited Cadmium on Au(111) with in situ Scanning Tunneling Microscopy.
Authors: BONDOS J. C. , GEWIRTH A. A. , NUZZO R. G.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Desilylation and a One‐Pot Desilylation‐Oxidation of Aliphatic tert‐ Butyldimethylsilyl Ethers Using Catalytic Quantities of PdCl2(CH3CN)2.
Authors: WILSON N. S. , KEAY B. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Nα‐Boc 4‐O‐Diethylphospho‐L‐azatyrosine, a Reagent Potentially Useful for the Synthesis of Signal Transduction Related Peptides.
Authors: YE B. , OTAKA A. , BURKE T. R. JUN.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanism of Kharash Reaction Catalyzed by Fe(CO)5. Part 2. Reinvestigation of Stereochemistry of BrCCl3 Addition to Methyl N‐ Acryloyl‐(S)‐prolinate.
Authors: TARAROV V. I. , SAVEL'EVA T. F. , BELOKON' YU. N.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cobalt Schiff Base Complex‐Catalyzed Oxidation of Anilines with tert‐ Butyl Hydroperoxide.
Authors: FOERSTER S. , RIEKER A. , MARUYAMA K. , MURATA K. , NISHINAGA A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive Deamination of Aromatic Amines with Nitric Oxide (NO).
Authors: ITOH T. , MATSUYA Y. , NAGATA K. , OHSAWA A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive O‐ and N‐Alkylations. Alternative Catalytic Methods to Nucleophilic Substitution.
Authors: FACHE F. , BETHMONT V. , JACQUOT L. , LEMAIRE M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: DNA Cleavage of Novel Propargylic Sulfones. Enhancement of Potency via Intercalating Interaction
Authors: DAI W.‐M. , FONG K. C. , DANJO H. , NISHIMOTO S. , SOLOW M. , MAK W. L. , YEUNG M. L.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Zinc(II)‐Catalyzed Transformation of Epoxides to Aziridines.
Authors: KUEHNAU D. , THOMSEN I. , JOERGENSEN K. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,1‐Diphenoxy‐2‐(phenylsulfonyl)cyclopropane as a Furan Annulating Agent.
Authors: POHMAKOTR M. , TAKAMPON A. , RATCHATAPHUSIT J.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Generation of Isothiazole Analogues of o‐Quinodimethane from Isothiazolo‐3‐sulfolenes.
Authors: TSO H.‐H. , CHANDRASEKHARAM M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Perfluoroperhydro‐7,10‐diazaphenanthrene
Authors: MAKAROV K. N. , POPOVA O. A. , LANTSEVA L. T. , MUKHIN V. YU. , MYSOV E. I.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 1,3,4,5‐Tetrahydro‐2‐benzoxepin Derivatives as Conformationally Restricted Analogues of Cyclamenaldehyde‐Type Compounds and as Intermediates for Highly Odor‐Active Homologues.
Authors: SKOUROUMOUNIS G. , WINTER B.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mimicking the Vancomycin Carboxylate Binding Site: Synthetic Receptors (I) and (II) for Sulfonates, Carboxylates, and N‐Protected α‐ Amino Acids in Water.
Authors: HINZEN B. , SEILER P. , DIEDERICH F.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.