bluuebunny/crossref_metadata_2025 huggingface dataset:
Fermentation Characteristics and Nutritional Value of Avena sativa Genotypes Ensiled with or without Napier Grass (Pennisetum purpureum)
Authors: Wodebo Kibreab Yosefe , Ejeta Taye Tolemariam , Cherkos Solomon Demeke , Terefe Weyessa Garedew , Wamatu Jane Nyaranga Ambuku , Equle Muluken Zeleke
Published: January 2023

The objective of this study was to investigate the fermentation characteristics and nutritional value of A. sativa genotypes ensiled either solely or in combination with P. purpureum 16791. Three different A. sativa genotypes (SRCPX80AB2806, ILRI_5527A, and ILRI_5526A) were harvested at the dough stage and ensiled solely or in combination with equal parts of P. purpureum 16791 with the addition of 3% molasses for all treatments in a completely randomized design with three replications over a period of 45 days. P. purpureum harvested at 60 days was ensiled and used as a control treatment. All treatments were evaluated for fermentation characteristics (pH, temperature, physical properties, and flieg point) and subjected to chemical analysis. The results showed that ensiling A. sativa ILRI_5527A, in combination with equal parts of P. purpureum 16791, produced the best silage with a significantly lower pH of 3.52. Optimal temperature (25 °C), nutrient losses based on the total dry matter (2.17%), gas (3.74%), and effluent (4.28%) were significantly (p < 0.0001) lower for T6 compared to the others. The dry matter recovery rate of T6 was significantly (p < 0.0001) higher than that of the others. T6 ranked first in the quality of physical properties (smell, color, mold, and texture). The highest dry matter (24%), organic matter (96.80%), crude fat (3.32%), and metabolizable energy (10.05 MJ/kg DM) were recorded for T6. The flieg score for T6 silage (96.6%) was also better than the others. In conclusion, ensiling A. sativa ILRI_5527 with equal parts of P. purpureum 16791 and the addition of 3% molasses improved fermentation characteristics and silage quality.
Complex Method of the Consumer Value Estimation on the Way to Risk-Free and Sustainable Production
Authors: Bolsunovskaya Marina V. , Gintciak Aleksei M. , Burlutskaya Zhanna V. , Zubkova Daria A. , Petryaeva Alexandra A. , Fedyaevskaya Darya E.
Published: January 2023

Sustainable consumption and production strive for the rational management of natural resources, which implies a transition to the production of fewer goods with the greatest consumer value. Consequently, the consumer value assessment is a key task in the product and service design. However, a large number of applied practices for assessing consumer value is a challenge for researchers. Multiple heterogeneous solutions without a common classification and structure do not allow comparing methods with each other. Thus, there is a demand for some universal algorithm for assessing consumer value, which would be a model for the development of individual industry practices. Therefore, the present research aims to develop a universal algorithm for assessing consumer value, which is a unified sample. The work analyzes the current expertise in assessing consumer value. The paper provides a comparison of mathematical tools for aggregate indicators in order to develop a general formula for assessing consumer value. As a result, an algorithm for assessing consumer value has been developed, which includes the following stages: market segmentation by consumer groups, taking into account their personal characteristics and needs; product hierarchical division into groups according to indicators valuable to the consumer; selection of a scale for evaluating indicators; hierarchical convolution, calculation of the consumer value of selected indicators and their aggregation into a final assessment in accordance with coefficients obtained as a result of the initial data analysis. As part of the algorithm verification, an example of the implementation of the algorithm steps based on expert assessment of the tourist product characteristics is proposed. At the next stage of the study, a register of mathematical tools will be specified to ensure the implementation of the algorithm steps, and practical testing on real data on several products from different industries.
Corporate Sustainable Development from the Perspective of the Effect of Institutional Investors’ Shareholding on Earnings Management
Authors: Zhao Shuo , Zhao Yang
Published: January 2023

To investigate the mechanism of improving corporate sustainable development, this paper uses the sample data of Shanghai and Shenzhen A-share listed companies between 2008–2017 and empirically investigates the effect of institutional investors’ shareholding on earnings management under sustainable development background. The results show that this shareholding significantly increases earnings management. After controlling the negative impact of earnings management on institutional investors and conducting GMM regression analysis, the shareholding and earnings management still present a significantly positive relation. Compared to unstable institutional investors, stable institutional investors have a relatively more effective supervision influence. This phenomenon indicates that China’s institutional investors do not effectively supervise the earnings management of listed companies. The research in this paper provides suggestions for the Chinese government to promote better corporate sustainable development policies in the capital market, such as improving the evaluation mechanism of institutional investors, further increasing other external supervision measures besides institutional investors for China’s capital market and encourage more stable institutional investors to participate in the capital market to reduce earnings manipulation.
LIBGRPP: A Library for the Evaluation of Molecular Integrals of the Generalized Relativistic Pseudopotential Operator over Gaussian Functions
Authors: Oleynichenko Alexander V. , Zaitsevskii Andréi , Mosyagin Nikolai S. , Petrov Alexander N. , Eliav Ephraim , Titov Anatoly V.
Published: January 2023

Generalized relativistic pseudopotentials (GRPP) of atomic cores implying the use of different potentials for atomic electronic shells with different principal quantum numbers give rise to accurate and reliable relativistic electronic structure models of atoms, molecules, clusters, and solids. These models readily incorporate the effects of Breit electron–electron interactions and one-loop quantum electrodynamics effects. Here, we report the computational procedure for evaluating one-electron integrals of GRPP over contracted Gaussian functions. This procedure was implemented in a library of routines named LIBGRPP, which can be integrated into existing quantum chemistry software, thus enabling the application of various methods to solve the many-electron problem with GRPPs. Pilot applications to electronic transitions in the ThO and UO2 molecules using the new library and intermediate-Hamiltonian Fock space relativistic coupled cluster method are presented. Deviations of excitation energies obtained within the GRPP approach from their all-electron Dirac–Coulomb–Gaunt counterparts do not exceed 50 cm−1 for the 31 lowest-energy states of ThO and 110 cm−1 for the 79 states of UO2. The results clearly demonstrate that rather economical tiny-core GRPP models can exceed in accuracy relativistic all-electron models defined by Dirac–Coulomb and Dirac–Coulomb–Gaunt Hamiltonians.
Effects of Tip Clearance and Impeller Eccentricity on the Aerodynamic Performance of Mixed Flow Fan
Authors: Liu Shulian , Guo Yizhe , Zhang Yuchi , Gu Cunkai , Yang Likang
Published: January 2023

The tip clearance and eccentricity of the impeller will affect the aerodynamic performance of the fan, and the impeller installation and vibration characteristics are relatively highly required if the tip clearance is too small. A reasonable tip clearance and excellent coaxially are necessary to ensure that the impeller does not rub with the shell and has superior aerodynamic performance when the fan is working. In the current study, a mixed flow fan was taken as the object and experimental explorations were performed on the C-type test rig designed according to GB/T1236 2000 Industrial fans-performance testing using standardized airways. By moving the airways to change the tip clearance, it was found that an overlarge tip clearance made the fan efficiency decrease significantly, and the efficiency change gradient was large. However, the gradient of efficiency change became smaller when reaching a certain clearance. Similarly, as the eccentricity became larger, the efficiency also decreased. To explore the influence of the optimal clearance and eccentricity of the fan on the fan’s performance, numerical simulations of the flow field inside the fan were carried out using FLUENT software corresponding to the experimental conditions. The influence of the tip clearance and eccentricity on the aerodynamic performance of the fan was revealed from the energy leakage perspective. Through theoretical and experimental analysis, we try to provide guidance on the design, installation and commissioning of fan tip clearance.
A Coal Gangue Identification Method Based on HOG Combined with LBP Features and Improved Support Vector Machine
Authors: Cheng Gang , Chen Jie , Wei Yifan , Chen Sensen , Pan Zeye
Published: January 2023

Identification of coal and gangue is one of the important problems in the coal industry. To improve the accuracy of coal gangue identification in the coal mining process, a coal gangue identification method based on histogram of oriented gradient (HOG) combined with local binary pattern (LBP) features and improved support vector machine (SVM) was proposed. First, according to the actual underground working environment of the mine, a machine vision platform for coal gangue identification was built and the coal gangue image acquisition experiment was carried out. Then, the images of coal and gangue were denoised by median filtering, and the coal and gangue features were extracted by using the HOG combined with LBP feature extraction algorithm, and these features were normalized and principal component analysis (PCA) reduced dimension to remove the correlation and redundancy between the features. Finally, SVM, SVM optimized by genetic algorithm (GA-SVM), SVM optimized by particle swarm optimization (PSO-SVM) algorithm, and SVM optimized by grey wolf optimization (GWO-SVM) algorithm were used as classifiers for identification and classification, respectively. The experimental results show that the GWO-SVM classification model has the highest accuracy, and the average classification accuracies were 96.49% and 94.82% of the training set and test set, respectively, which shows that grey wolf algorithm to optimize support vector machine has a good effect on classification of coal gangue images, which proves the feasibility and accuracy of the proposed method.
A Novel EGFR Targeted Immunotoxin Based on Cetuximab and Type 1 RIP Quinoin Overcomes the Cetuximab Resistance in Colorectal Cancer Cells
Authors: Landi Nicola , Ciaramella Vincenza , Ragucci Sara , Chambery Angela , Ciardiello Fortunato , Pedone Paolo V. , Troiani Teresa , Di Maro Antimo
Published: January 2023

Cetuximab is a monoclonal antibody blocking the epidermal growth factor receptor (EGFR) in metastatic colorectal cancer (mCRC). However, cetuximab treatment has no clinical benefits in patients affected by mCRC with KRAS mutation or in the presence of constitutive activation of signalling pathways acting downstream of the EGFR. The aim of this study was to improve cetuximab’s therapeutic action by conjugating cetuximab with the type 1 ribosome inactivating protein (RIP) quinoin isolated from quinoa seeds. A chemical conjugation strategy based on the use of heterobifunctional reagent succinimidyl 3-(2-pyridyldithio)propionate (SPDP) was applied to obtain the antibody-type 1 RIP chimeric immunoconjugate. The immunotoxin was then purified by chromatographic technique, and its enzymatic action was evaluated compared to quinoin alone. Functional assays were performed to test the cytotoxic action of the quinoin cetuximab immunoconjugate against the cetuximab-resistant GEO-CR cells. The novel quinoin cetuximab immunoconjugate showed a significant dose-dependent cytotoxicity towards GEO-CR cells, achieving IC50 values of 27.7 nM (~5.0 μg/mL) at 72 h compared to cetuximab (IC50 = 176.7 nM) or quinoin (IC50 = 149.3 nM) alone assayed in equimolar amounts. These results support the therapeutic potential of quinoin cetuximab immunoconjugate for the EGFR targeted therapy, providing a promising candidate for further development towards clinical use in the treatment of cetuximab-resistant metastatic colorectal cancer.
A Fatal Case of Native Valve Endocarditis with Multiple Embolic Phenomena and Invasive Methicillin-Resistant Staphylococcus aureus Bacteremia: A Case Report from the Maldives
Authors: Shafeeq Ali , Imad Hisham Ahmed , Azhad Ahmed , Shareef Migdhaadh , Najmy Mohamed Shaneez , Siraj Mohamed Mausool , Sunil Mohamed , Rafeeu Rimsha , Moosa Aishath Sofa , Shaheed Ahmed , Ngamprasertchai Thundon , Matsee Wasin , Aung Pyae Linn , Nguitragool Wang , Shioda Tatsuo
Published: January 2023

Infective endocarditis (IE) is a life-threatening condition caused by infection within the endocardium of the heart and commonly involves the valves. The subsequent cascading inflammation leads to the appearance of a highly friable thrombus that is large enough to become lodged within the heart chambers. As a result, fever, fatigue, heart murmurs, and embolization phenomena may be seen in patients with IE. Embolization results in the seeding of bacteria and obstruction of circulation, causing cell ischemia. Of concern, bacteria with the potential to gain pan-drug resistance, such as methicillin-resistant Staphylococcus aureus (MRSA), are increasingly being identified as the causative agent of IE in hospitals and among intravenous drug abusers. We retrospectively reviewed de-identified clinical data to summarize the clinical course of a patient with MRSA isolated using an automated blood culture system. At the time of presentation, the patient showed a poor consciousness level, and the calculated Glasgow scale was 10/15. A high-grade fever with circulatory shock indicated an occult infection, and a systolic murmur was observed with peripheral signs of embolization. This case demonstrated the emerging threat of antimicrobial resistance in the community and revealed clinical findings of IE that may be helpful to clinicians for the early recognition of the disease. The management of such cases requires a multi-specialty approach, which is not widely available in small-island developing states such as the Maldives.
Multiverse Predictions for Habitability: Origin of Life Scenarios
Authors: Sandora McCullen , Airapetian Vladimir , Barnes Luke , Lewis Geraint F. , Pérez-Rodríguez Ileana
Published: January 2023

If the origin of life is rare and sensitive to the local conditions at the site of its emergence, then, using the principle of mediocrity within a multiverse framework, we may expect to find ourselves in a universe that is better than usual at creating these necessary conditions. We use this reasoning to investigate several origin of life scenarios to determine whether they are compatible with the multiverse, including the prebiotic soup scenario, hydrothermal vents, delivery of prebiotic material from impacts, and panspermia. We find that most of these scenarios induce a preference toward weaker-gravity universes, and that panspermia and scenarios involving solar radiation or large impacts as a disequilibrium source are disfavored. Additionally, we show that several hypothesized habitability criteria which are disfavored when the origin of life is not taken into account become compatible with the multiverse, and that the emergence of life and emergence of intelligence cannot both be sensitive to disequilibrium production conditions.
The Higgs Trilinear Coupling and the Scale of New Physics for the SM-Axion-Seesaw-Higgs Portal Inflation (SMASH) Model
Authors: Das C.R. , Huitu Katri , Kärkkäinen Timo J.
Published: January 2023

In the extended scalar sector of the SMASH (Standard Model - Axion-Seesaw-Higgs portal inflation) framework, we conduct a phenomenological investigation of the observable effects. In a suitable region of the SMASH scalar parameter spaces, we solve the vacuum metastability problem and discuss the one-loop correction to the triple Higgs coupling, λHHH. The λHHH and SM Higgs quartic coupling λH corrections are found to be proportional to the threshold correction. A large λHHH correction (≳5%) implies vacuum instability in the model and thus limits the general class of theories that use threshold correction. We performed a full two-loop renormalization group analysis of the SMASH model. The SMASH framework has also been used to estimate the evolution of lepton asymmetry in the universe.
Microchimerism, PERV and Xenotransplantation
Authors: Denner Joachim
Published: January 2023

Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish cell lineages within the mother. Microchimerism was also described after the transplantation of human organs in human recipients. Consequently, microchimerism may also be expected in xenotransplantation using pig cells or organs. Indeed, microchimerism was described in patients after xenotransplantations as well as in non-human primates after the transplantation of pig organs. Here, for the first time, a comprehensive review of microchimerism in xenotransplantation is given. Since pig cells contain porcine endogenous retroviruses (PERVs) in their genome, the detection of proviral DNA in transplant recipients may be misinterpreted as an infection of the recipient with PERV. To prevent this, methods discriminating between infection and microchimerism are described. This knowledge will be important for the interpretation of screening results in forthcoming human xenotransplantations.
IFN-γ-Based ELISpot as a New Tool to Detect Human Infections with Borna Disease Virus 1 (BoDV-1): A Pilot Study
Authors: Eidenschink Lisa , Knoll Gertrud , Tappe Dennis , Offner Robert , Drasch Thomas , Ehrl Yvonne , Banas Bernhard , Banas Miriam C , Niller Hans Helmut , Gessner André , Köstler Josef , Lampl Benedikt M J , Pregler Matthias , Völkl Melanie , Kunkel Jürgen , Neumann Bernhard , Angstwurm Klemens , Schmidt Barbara , Bauswein Markus
Published: January 2023

More than 40 human infections with the zoonotic Borna disease virus 1 (BoDV-1) have been reported to German health authorities from endemic regions in southern and eastern Germany. Diagnosis of a confirmed case is based on the detection of BoDV-1 RNA or BoDV-1 antigen. In parallel, serological assays such as ELISA, immunoblots, and indirect immunofluorescence are in use to detect the seroconversion of Borna virus-reactive IgG in serum or cerebrospinal fluid (CSF). As immunopathogenesis in BoDV-1 encephalitis appears to be driven by T cells, we addressed the question of whether an IFN-γ-based ELISpot may further corroborate the diagnosis. For three of seven BoDV-1-infected patients, peripheral blood mononuclear cells (PBMC) with sufficient quantity and viability were retrieved. For all three patients, counts in the range from 12 to 20 spot forming units (SFU) per 250,000 cells were detected upon the stimulation of PBMC with a peptide pool covering the nucleocapsid protein of BoDV-1. Additionally, individual patients had elevated SFU upon stimulation with a peptide pool covering X or phosphoprotein. Healthy blood donors (n = 30) and transplant recipients (n = 27) were used as a control and validation cohort, respectively. In this pilot study, the BoDV-1 ELISpot detected cellular immune responses in human patients with BoDV-1 infection. Its role as a helpful diagnostic tool needs further investigation in patients with BoDV-1 encephalitis.
Cancer Vaccines for Triple-Negative Breast Cancer: A Systematic Review
Authors: Hosseini Mina , Seyedpour Simin , Khodaei Behzad , Loghman Amir-Hossein , Seyedpour Nasrin , Yazdi Mohammad-Hossein , Rezaei Nima
Published: January 2023

Triple-negative breast cancer (TNBC) is the subtype of breast cancer with the poorest outcomes, and is associated with a high risk of relapse and metastasis. The treatment choices for this malignancy have been confined to conventional chemotherapeutic agents, due to a lack of expression of the canonical molecular targets. Immunotherapy has been recently changing the treatment paradigm for many types of tumors, and the approach of evoking active immune responses in the milieu of breast tumors through cancer vaccines has been introduced as one of the most novel immunotherapeutic approaches. Accordingly, a number of vaccines for the treatment or prevention of recurrence have been developed and are currently being studied in TNBC patients, while none have yet received any approvals. To elucidate the efficacy and safety of these vaccines, we performed a systematic review of the available literature on the topic. After searching the PubMed, Scopus, Web of Science, Embase, Cochrane CENTRAL, and Google Scholar databases, a total of 5701 results were obtained, from which 42 clinical studies were eventually included based on the predefined criteria. The overall quality of the included studies was acceptable. However, due to a lack of reporting outcomes of survival or progression in some studies (which were presented as conference abstracts) as well as the heterogeneity of the reported outcomes and study designs, we were not able to carry out a meta-analysis. A total of 32 different vaccines have so far been evaluated in TNBC patients, with the majority belonging to the peptide-based vaccine type. The other vaccines were in the cell or nucleic acid (RNA/DNA)-based categories. Most vaccines proved to be safe with low-grade, local adverse events and could efficiently evoke cellular immune responses; however, most trials were not able to demonstrate significant improvements in clinical indices of efficacy. This is in part due to the limited number of randomized studies, as well as the limited TNBC population of each trial. However, due to the encouraging results of the currently published trials, we anticipate that this strategy could show its potential through larger, phase III randomized studies in the near future.
Changes in Attitudes toward COVID-19 Vaccination and Vaccine Uptake during Pandemic
Authors: Markovic-Denic Ljiljana , Nikolic Vladimir , Pavlovic Nevenka , Maric Gorica , Jovanovic Aleksa , Nikolic Aleksandra , Marusic Vuk , Sipetic Grujicic Sandra , Pekmezovic Tatjana
Published: January 2023

The epidemic control approach was based on non-pharmacological measures in the first year of the COVID-19 pandemic, followed by vaccine uptake in the second year. Vaccine uptake depends on the individual attitude toward vaccination. The aim was to assess the changes in attitudes regarding COVID-19 vaccine protection during the pandemic and to determine the vaccination uptake concerning these attitudes. A panel study on COVID-19 vaccine attitudes and vaccination against COVID-19 was conducted in Belgrade, Serbia. The first survey was carried out in May–June 2020, and the second survey was organized in August–September 2021. During the baseline testing performed in 2020, 64.4% of respondents believed that the future vaccine against COVID-19 could protect against the COVID-19 disease, while 9.7% thought that it could not, and 25.9% were unsure. One year later, in the second survey, the percentage of participants with positive attitudes was slightly lower (64.7% vs. 62.5%). However, negative attitudes turned positive in 34% of cases, and 28.9% became unsure about vaccine protection (p < 0.001). Out of the 390 participants included in the study, 79.7% were vaccinated against COVID-19 until follow-up. There is a statistically significant difference in vaccination uptake compared to the baseline attitude about the protection of the COVID-19 vaccine. The main finding of our study is that the majority of participants who were vaccine hesitant during the baseline testing changed their opinion during the follow-up period. Additionally, the baseline attitude about the protection of the COVID-19 vaccine has been shown to be a potential determinant of vaccination uptake.
Immune Response to Vaccination against COVID-19 at Different Second-Dose Intervals and Their Associations with Metabolic Parameters
Authors: Szczerbiński Łukasz , Okruszko Michał Andrzej , Szabłowski Maciej , Warpechowski Jędrzej , Paszko Adam , Citko Anna , Konopka Paulina , Bauer Witold , Krętowski Adam Jacek
Published: January 2023

Obesity and diabetes are associated with severe outcomes of coronavirus disease (COVID-19). Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been proven protective against infection and severe COVID-19. However, the immune response of metabolically burdened individuals to the vaccines remains unclear. Thus, we aimed to assess whether the metabolic status of individuals affects their humoral immune responses to the vaccination. Moreover, we evaluated whether the interval between the first two doses influenced antibody concentration. Sixty-seven individuals (21 males, 46 females) were vaccinated with the BNT162b2 mRNA COVID-19 vaccine. Fifty-four individuals were vaccinated with the second dose after 3 weeks and 13 after 5 weeks. We measured the antibody titers in all participants during the 19-week follow-up period. Patients diagnosed with COVID-19 were excluded. In the 5-week interval group, a significantly higher level of maximal antibody titers was observed. However, there were no differences in antibody concentrations after 19 weeks and no significant correlation between cardiometabolic factors and humoral response. The elongation of second-dose timing to 5 weeks leads to a higher acute antibody response but does not change long-term levels of antibody titers. Moreover, dysregulation of metabolic parameters does not lead to a diminished immune response to vaccination.
Nitrogen balance harmonization for sustainable intensifi cation of poultry production
Authors:   Federal State Budgetary Educational Institution of Higher Education “Northern Trans-Ural State Agricultural University”, Russia, Tyumen, Kovaleva O. V. , Demin E. A. ,   Federal State Budgetary Educational Institution of Higher Education “Northern Trans-Ural State Agricultural University”, Russia, Tyumen, Kostomakhin N. M. ,   Federal State Budgetary Educational Institution of Higher Education “Russian State Agrarian University – Moscow Timiryazev Agricultural Academy”, Russia, Moscow, Punegova V. V. ,   Federal State Budgetary Educational Institution of Higher Education “Northern Trans-Ural State Agricultural University”, Russia, Tyumen
Published: January 2023

There is a close link between food production and population growth, as well as the need to create a scientific basis to minimize the impact associated with emissions into the environment. Of the 10 % of feed assimilated by animals as a result of their enzymatic decomposition, a tenth of pollutants will be released directly from animals into the atmosphere. Using only such an approach in the study of nitrogen transformation in agroecosystems gives only an approximate vision of the distribution of substances, in particular nitrogen, since in each case the ratio of the analyzed nitrogen-containing compounds may be the result not only of the activity of denitrifiers, but also of the unaccounted activity of microorganisms of other physiological groups involved in nitrogen transformation. The purpose of the work was to study the key points of nitrogen formation and release in the agro-ecosystem on the example of a scientific and production experiment in a poultry farm. The research was carried out under production conditions on broilers in an experimental workshop, in which four sections (three experimental and one control) were formed: the 1st section (experimental) – diatomite (1,0 cm layer), the 2nd section (experimental) – diatomite (0,5 cm layer), the 3rd section (experimental) – diatomite (0,5 cm layer) + sawdust (2,5 cm layer), the 4th section (control) – sawdust (layer 3,0 cm). It can be concluded on the base of data obtained that the formation of nitrogenous compounds occurs throughout the entire production process, as a result of which nitrogen is released into the atmosphere during the vital activity of poultry during storage and composting of production waste (droppings), as well as when organic fertilizers are applied to the soil.
The use of beech flour in the diet of parent herd of quails
Authors:   Siberian Scientifi c and Research Institute of Poultry – a branch of the Federal State Budget Scientifi c Institution “Omsk Agrarian Scientifi c Center”, Russia, Omsk Region, Morozovka, Shpуnova S. A. , Yadrishchenskaya O. A. ,   Siberian Scientifi c and Research Institute of Poultry – a branch of the Federal State Budget Scientifi c Institution “Omsk Agrarian Scientifi c Center”, Russia, Omsk Region, Morozovka, Selina T. V. ,   Siberian Scientific and Research Institute of Poultry – a branch of the Federal State Budget Scientifi c Institution “Omsk Agrarian Scientifi c Center”, Russia, Omsk Region, Morozovka, Basova E. A. ,   Siberian Scientifi c and Research Institute of Poultry – a branch of the Federal State Budget Scientifi c Institution “Omsk Agrarian Scientifi c Center”, Russia, Omsk Region, Morozovka
Published: January 2023

It is necessary not only to increase the production of poultry products, but also to improve its quality while reducing the prime-cost. One of the solutions to this problem is the use of diff erent feed additives in poultry feeding, made from components of natural origin to meet the needs of poultry, which makes it possible to use for the production of compound feed. Recently, Russia has been paying more and more attention to such a sub-branch of poultry farming as quail farming. This is due to the fact that its products are in demand in the modern market, and production does not require large investments, which makes it possible to receive high incomes from the sale of both meat and eggs in the shortest possible time. The purpose of the research was to study the influence of compound feeds with beech fl our on the productivity of quails of the parent herd. The research was aimed at studying the egg productivity of quails. The results of a study on quails of the parent herd when using compound feeds with 1,0 % beech fl our have been presented in the article. Due to the better assimilation of feed nutrients, the introduction of beech fl our into the structure of the diet helped to increase egg productivity and reduced feed expenditures for products. Thus, when using the developed compound feeds, the average daily feed consumption decreased by 0,71 %. Data from the balance experiment showed that when using compound feed with 1,0 % beech fl our protein digestibility increased by 1,16 abs.%. It has been established that the use of compound feed with the introduction of 1,0 % beech fl our was of practical importance due to an increase in the productivity of quails and reduction in the prime-cost by 1,93 % for production of one hatchable egg.
The association of productive and reproductive traits in cows of genealogical line Refl ection Sovereign in different lactations
Authors:   Federal State Budgetary Educational Institution of Higher Education “Ural Institute of the State Fire Service of the Ministry of Emergency Situations of Russia”, Russia, Ekaterinburg, Gorelik A. S. , Gorelik O. V. ,   Federal State Budgetary Educational Institution of Higher Education “Ural State Agrarian University”, Russia, Ekaterinburg, Kharlap S. Yu. ,   Federal State Budgetary Educational Institution of Higher Education “Ural State Agrarian University”, Russia, Ekaterinburg, Fedoseeva N. A. ,   Federal State Budgetary Educational Institution of Higher Education “Russian State Agrarian Correspondence University”, Russia, Moscow region, Balashikha, Romanova N. V. ,   Federal State Budgetary Educational Institution of Higher Education “Russian State Agrarian Correspondence University”, Russia, Moscow region, Balashikha
Published: January 2023

In order to effectively carry out breeding work in dairy cattle, it is necessary to take into account the association between economically useful traits in cows. The magnitude of the positive and negative correlation varies depending on the direction of selection, feeding conditions and housing of animals. The purpose of the work was to study the association between productive and reproductive traits in cows of the genealogical line Refl ection Sovereign 198998 in diff erent lactations. It was found as a result of the conducted research that the majority of cows belonging to the genealogical line Refl ection Sovereign 198998 (64,0 %) were young cows in the fi rst and second lactations. Cows with mature (third) lactation had the highest milk yield. Their milk yield was 8834±288,54 kg, which was 1555 kg or 21,4 % more than that of the fi rst-calf heifers. There was a natural increase in milk yield from the first lactation to mature age, and then a gradual decrease until the end of the use of animals. The difference in the value of milk yield for adjacent lactations was insignifi cant. The average daily milk yields of cows for diff erent lactations were quite high and range from 15,0 to 30,0 kg or more. There was a direct association between milk yield for the entire lactation and the duration of the open day’s period. The correlation coeffi cients between these traits were from +0,49 to +0,85 in cows of the genealogical line Refl ection Sovereign 198998, which indicates an average and high correlation of traits. This circumstance should be taken into account, because excessive lengthening of lactation leads to a decrease in the level of reproduction in the herd. The increase in milk yield positively correlated with the mass fraction of fat in milk and the yield of milk fat during lactation.
Characteristics of rabbits of domestic breeds and ways to increase their productivity in the region of the Middle Urals
Authors:   Federal State Budgetary Educational Institution of Higher Education “Moscow State Academy of Veterinary Medicine and Biotechnology – MVA named after K. I. Skryabin”, Russia, Moscow, Kudrevatykh I. A.
Published: January 2023

Russia today occupies one of the last places in the world in the production of rabbit meat (about 10–15 thousand tons per year). In order to increase the production of rabbit meat in Russia imported meat breeds and crosses are being bred, existing domestic breeds are being improved. The housing of imported breeds and crosses requires the construction of expensive rabbit houses with climate control. The most popular domestic breeds in different regions of Russia are White giant – 12,87 % and Soviet chinchilla – 9,35 %, which are acclimatized to the harsh climatic conditions of our country and do not require large costs for housing. The purpose of the research was to characterize rabbits of domestic breeds and analyze ways to increase their productivity in the region of the Middle Urals. It has been proved on the base of comprehensive studies that rabbits of Soviet chinchilla and White giant breeds have changed the parameters of the conformation, live weight, and the intensity of growth of young animals in the direction of meat productivity. The influence of the quantitative and qualitative composition of the intestinal microfl ora of young rabbits on the dynamics of live weight has been proved. The positive effect of the use of line breeding on the growth rate of young animals under the conditions of the Middle Urals has been established. The analysis of economic data showed that the profit from the sale of meat of rabbits of Soviet chinchilla breed grown up to 3 months of age and was 4,09 % higher compared to herdmates of White giant breed. At the same time, when slaughtered at the age of 110 days, the indicators were higher in White giant rabbits, which should be taken into account when conducting breeding work with these breeds.
The use of premixes in feeding of replacement young cattle
Authors:   Federal State Budgetary Educational Institution of Higher Education “Volgograd State Agrarian University”, Russia, Volgograd, Nikolaev S. I. , Kupriyanov S. N. ,   Federal State Budgetary Educational Institution of Higher Education “Volgograd State Agrarian University”, Russia, Volgograd
Published: January 2023

Insufficient intake of minerals into the body of young animals leads to the fact that calves have a lag in growth and development, which aff ects the overall health and further productivity. The study of the feasibility of using premixes with improved formulations in feeding replacement young cattle is relevant. The purpose of the research was to study the increase in the efficiency of rearing replacement heifers, their achievement of earlier economic and physiological maturity due to the use of premix Megamix Noris and Megamix Vitula Opti in the rations of calves. The scientific and economic experiment was carried out under the conditions of OOO “EkoNivaAgro” in the Bobrovsky area in the Voronezh region. Comprehensive studies have been carried out to study the effectiveness of the use of the studied premixes, developed according to improved recipes, in the rations of replacement heifers. It has been experimentally proved that the use of premixes Megamix Noris (up to 6 months of age) and Megamix Vitula Opti (from 6 to 12 months of age) it contributed to an increase in the live weight of replacement heifers for the period of the experiment by 7,74 %, the increase in average daily gains by 8,63 %. An analysis of the economic eff ectiveness of rearing replacement heifers showed that the additional profit from the sale of young animals in live weight amounted to 38,7 thousand rubles. When calculating the level of economic eff ectiveness of milk production, it was revealed that the studied premixes as part of the rations for replacement heifers contributed to obtaining additional profit from the fi rst-calf heifer in the amount of 2,288,29 rubles, which led to the increase in the level of profitability by 3,08 abs.%.
Diotogène, Sur la royauté. Commentaire historique et politique pour un essai de datation
Authors: Bouchet Christian , Gangloff Anne , Widmer Marie
Published: January 2023

Of the three preserved neopythagorean treatises On Kingship, that of Diotogenes is probably the one that best allows an exploration of the problematic question of dating. The present historical commentary first outlines Diotogenes’ definition of the “good king” and his qualities. It then gathers the main clues converging towards a dating at the end of the Hellenistic period or at the beginning of the Principate (1st century BCE-1st century CE). It does so by examining the echoes with the political language of the Hellenistic kingship and by attempting to locate certain great political virtues in the evolution of monarchical ideology.
How to Date the Timeless? The Difficult Problem of the Pseudo–Pythagorean Treatises On Kingship
Authors: Roskam Geert
Published: January 2023

Cet article propose un examen critique des principaux parallèles entre les traités néopythagoriciens Sur la royauté et la pensée politique de Plutarque. Les Néopythagoriciens et Plutarque s’accordent fondamentalement sur l’idée que le bon roi 1) imite Dieu ; 2) contrôle ses passions, est gouverné par la raison ; 3) est un modèle pour ses sujets ; 4) est une «loi animée». Cependant, chaque auteur poursuit un objectif propre et ignorer cette uoluntas auctoris pose un problème de méthode. En outre, faire la liste des idées communes ne donne pas d’information certaine pour dater Diotogène, Sthénidas et Ecphante.
A Note on the Linear A et B Ideogram AB 131/VIN(um) ‘Wine’ and Its Variants: References to Time Notation?
Authors: Salgarella Ester
Published: January 2023

Cet article se propose d’explorer la possibilité de détecter des références à la notation temporelle exprimée de manière sémasiographique dans l’idéogramme du vin en linéaire A et en linéaire B : AB 131/ VIN(um). Ce signe se présente sous trois variantes, à savoir AB 131a, AB 131b et A 131c, cette dernière variante n’étant attestée qu’en linéaire A. Des éléments de preuve seront présentés pour démontrer que la modification graphique de la forme du signe principal (AB 131a) a été utilisée comme méthode pour donner naissance à des variantes du signe (AB 131b, A 131c) destinées à transmettre des informations chronologiques de manière sémasiographique, c’est-à-dire sans avoir recours à l’écriture phonétique.
L’archaia moira : une invention de Dicéarque
Authors: Paradiso Annalisa
Published: January 2023

On s’accorde à penser que les sources du traité Sur les Constitutions d’Hérakleidès Lembos sont les nombreuses Constitutions rédigées par Aristote et ses élèves. Comme on ignore de quelle façon ils ont collaboré, rien n’assure que la Constitution des Lacédémoniens utilisée par Hérakleidès soit l’oeuvre d’Aristote lui-même. La contradiction entre ce qu’il dit dans la Politique et le système de la moira mentionné par Hérakleidès donne plutôt à penser que ce n’est pas le cas, et d’autres indices, relatifs notamment aux repas en commun, confirment cette opinion et orientent vers le seul membre du groupe d’Aristote auquel, dans l’Antiquité, on attribuait une Constitution des Lacédémoniens, qui a eu un grand succès : Dicéarque de Messènè.
Les sphinx sur la statue de Prima Porta. L’apothéose d’Auguste
Authors: Petit Thierry
Published: January 2023

Sur la statue d’Auguste découverte dans la villa de Livie à Prima Porta, les deux sphinx représentés sur les épaulières de la cuirasse, de part et d’autre de la tête du Princeps, n’ont pas reçu d’explication satisfaisante ni qui fasse consensus. Une interprétation du sphinx comme symbole d’apothéose permet de proposer une autre vision des deux hybrides et de réexaminer également d’autres figures de cette iconographie, ainsi que la date assignée à l’oeuvre.
A importância da literatura para o aprendizado uma reflexão embasada na leitura do romance “Caetés”, de Gracilano Ramos
Authors: Santos Suelí Bispo Pereira , Neto Moisés Monteiro de Melo
Published: January 2023

Esta pesquisa, se propõe compreender a importância da literatura e os incentivos apresentados, desde as fases iniciais, promovendo o interesse pela leitura e desenvolvendo o pensamento criativo até a fase adulta. Usamos como base  um estudo sobre o romance “Caetés”, de Graciliano Ramos, de 1933, possibilitando estabelecer as ligações resultantes da leitura na evolução do cidadão contemplando a importância da aplicação de metodologias que estimulem a curiosidade e não abordar a leitura apenas como uma obrigação dentro do âmbito escolar, pelo contrário, que a leitura se extenda no ambiente familiar social, e sendo uma instrumento da construção de personalidade e intelecto  e social,  favorecendo também, o conhecimento e uma forma de ampliar os conhecimentos em diversos assuntos, inclusive a diversidade cultural e social, promovendo mais respeito e harmonia para uma nova geração. Esta pesquisa foi possível por estudos bibliograficos de referências importantes de autotes diversos que enriquecem o conhecimento e possibiitam a melhor compreensão e desenvolvimento deste.
Potenciais interações de drogas em pacientes de terapia antirretroviral: uma revisão integrativa
Authors: Schuch Francieli Mônica , Sá Thalita Helena Reis , Silva Mizael da , Ferraz Renato Ezon Melo , Neto Pedro Cunha Mendes , Moreno Jenny Maldonado , Filho Kleber de Jesus Serrão Mendes , Silveira Philipe Sousa , Reis Lucas Machado dos , Schafer Manoela Sandri , Concer Ana Alice Cunha , Luizon Mônica Piacentini , Damasceno Victor Yuri Pereira , Travassos Layna Louise Cardoso Gonçalves , Poz Bruno Gemilaki Dal , Salomão Isabela Reis , Souza Hugo Miguel Costa de , Bosetti Júlia , Perin Carlos Henrique Dacoregio , Machado Fernanda Lima , Luz Laércio Junior Ribeiro da , Feitosa Mayara Pessoa , Rodrigues Ana Paula de Oliveira , Pasquarelli Bianca Dela Mura , Carvalho Laryssa Inácio , Szortyka Henrique , Mata Leandro Lucas Lopes da , Neto José de Ribamar da Silva Garrido , Carneiro Larissa Saraiva Garrido , Filho José Roberto Lopes Costa
Published: January 2023

Possíveis interações medicamentosas devem ser levadas em consideração ao selecionar um regime antirretroviral. Uma revisão detalhada dos medicamentos concomitantes pode ajudar na criação de um regime que minimize as interações indesejáveis. O potencial para interações medicamentosas deve ser avaliado quando qualquer novo medicamento (incluindo agentes de venda livre) é adicionado a um regime antirretroviral existente. A maioria das interações medicamentosas com medicamentos antirretroviral é mediada por inibição ou indução do metabolismo hepático de medicamentos. Este estudo trata-se de uma revisão integrativa, cujo objetivo foi compreender as possíveis interações de drogas em pacientes com infecção pelo HIV em processo de terapia antirretroviral. Após análise dos dados, concluiu-se que há riscos reais de interações medicamentosas a partir do uso de 5 ou mais medicamentos, por um tempo superior a seis anos. Os principais riscos apontados nesse sentido foram interferência na resposta terapêutica, aumento de reações adversas toxidade nos sistemas cardiovascular e nervoso central e dificuldades para detecção de resistência do HIV aos medicamentos antirretrovirais.
Bioinspired Jellyfish Microparticles from Microfluidics
Authors: Yang Chaoyu , Yu Yunru , Zhao Yuanjin , Shang Luoran
Published: January 2023

Nonspherical particles have attracted increasing interest because of their shape anisotropy. However, the current methods to prepare anisotropic particles suffer from complex generation processes and limited shape diversity. Here, we develop a piezoelectric microfluidic system to generate complex flow configurations and fabricate jellyfish-like microparticles. In this delicate system, the piezoelectric vibration could evolve a jellyfish-like flow configuration in the microchannel and the in situ photopolymerization could instantly capture the flow architecture. The sizes and morphologies of the particles are precisely controlled by tuning the piezoelectric and microfluidic parameters. Furthermore, multi-compartmental microparticles with a dual-layer structure are achieved by modifying the injecting channel geometry. Moreover, such unique a shape endows the particles with flexible motion ability especially when stimuli-responsive materials are incorporated. On the basis of that, we demonstrate the capability of the jellyfish-like microparticles in highly efficient adsorption of organic pollutants under external control. Thus, it is believed that such jellyfish-like microparticles are highly versatile in potential applications and the piezoelectric-integrated microfluidic strategy could open an avenue for the creation of such anisotropic particles.