bluuebunny/crossref_metadata_2025 huggingface dataset:
Saudi Undergraduate Students’ Preferences toward Tests and Test Anxiety Differences in Blended Learning
Authors: Alghamdi Nawal Ali
Published: April 2022

In blended learning, which has become very common due to the prevailing conditions, tests play a pivotal role, as the percentage of reliance on online tests has increased more than on paper tests. This study aims to measure the percentage of test anxiety in online and paper-based tests. It also seeks to determine the students' most desire for online paper-based tests in terms of test anxiety. 138 students participated in this study, and a questionnaire was used to measure the level of test anxiety and students' preferences for the two test types in relation to test anxiety. The results showed that students experience more test anxiety in paper-based tests than on online tests. Students also showed a significant tendency toward using online tests for testing in relation to test anxiety. They prefer online tests more than paper tests to cope with test anxiety.
Identifying Causes of Pragma-linguistic Difficulties in Translating the Embedded Meanings of the Quranic Love Words into English: A Comparative Interdisciplinary Study
Authors: Alhaj Ali Albashir Mohammed
Published: April 2022

The current research paper aims at identifying the pragma-linguistic difficulties faced by the translators of the meaning of the Holy Qura’n whilst rendering the Quranic love words into English, specifically in the work of Mohammed. A. S. Abdel Haleem, Mohammed. M Pickthall and Mohammed Khan and Mohammed Taj Al-Din Al-Hilali. Also, the study aims to identify the translation strategies adopted by the three translators in renderings the Quranic love words into English. Also, the study intends to prospect how the three translators come to grips with pragma-linguistic difficulties in their renderings of the Quranic love words into English. Three examples of the Quranic love words were intendedly selected to tackle the research problems. The study revealed that translating the Quranic love words is even more difficult than translating love words in other genres because of the religious genre. Also, the study showed that translating the embedded meanings in the Quranic texts is not quite easy. This is because Qur'anic love words involve very ingenious differences in meaning that are difficult to understand.
Gambaran Pengetahuan Masyarakat Melati Tentang Nutrisi Selama Pandemi Covid-19
Authors: Firmansyah Ferdy , Susanti Emma , Pratiwi Erniza , Sinata Novia
Published: April 2022

ABSTRAK Prevalensi Covid-19 yang muncul pada akhir 2019 terus meningkat hingga saat ini dan masih dikategorikan sebagai pandemi. Berbagai upaya telah dilakukan mulai dari penerapan protokol kesehatan, mengonsumsi vitamin, hingga melakukan aktivitas dari rumah. Upaya tersebut harus dilakukan oleh setiap individu untuk menekan dan memutus rantai penyebaran virus ini. Oleh karena itu perlu diberikan penyuluhan dengan tujuan meningkatkan kesadaran dan pengetahuan masyarakat tentang Covid-19 serta nutrisi yang diperlukan selama pandemi. Kegiatan ini diikuti sebanyak 30 responden di Kecamatan Tampan, Pekanbaru dengan menggunakan media leaflet. Pada saat pemberian informasi juga diberikan masker serta vitamin C. Vitamin dapat berfungsi sebagai antioksidan dan digunakan untuk meningkatkan daya tahan tubuh selama pandemi. Berdasarkan kegiatan, terjadi peningkatan pengetahuan masyarakat yang dibuktikan dengan nilai rerata pre-test 44,04 menjadi 92,87 pada saat post-test. Disarankan kedepannya untuk melakukan pengabdian dengan ruang lingkup yang lebih besar. Kata Kunci: Covid-19, Nutrisi, Pengetahuan ABSTRACT The prevalence of Covid-19 which emerged at the end of 2019 continues to increase until now and is still categorized as a pandemic. Various efforts have been made, starting from implementing health protocols, vitamins consumptions, and activities or work from home (WFH). These efforts must be made by each individual to suppress and break the chain of infection stopping covid-19. Therefore, it is necessary to provide counseling with the aim of increasing public awareness and knowledge about Covid-19 and the nutrition needed during the pandemic. This activity was attended by 30 respondents in Tampan District, Pekanbaru using leaflet media. At the time of providing information, masks and vitamin C were also given. Vitamins can function as antioxidants and are used to increase body resistance during a pandemic. Based on the activity, there was an increase in public knowledge as evidenced by the mean value of the pre-test from 44.04 to 92.87 at the time of the post-test. It is recommended in the future to do service with a larger scope. Keywords: covid-19, nutrition, knowledge
Pembekalan dan Pembuatan Hand Sanitizer Daun Sirih (Piper Betle Linn.) di Desa Ngranti Kecamatan Boyolangu
Authors: Susanto Heru , Elistya Novintan , S Yunita Dyah , Amalia Ana
Published: April 2022

ABSTRAK COVID-19 telah menjadi masalah kesehatan dunia.WHO resmi menyatakannya sebagai suatu pandemi pada 11 Maret 2020. Berdasarkan data dari Satgas Covid-19 pada tanggal 19 Januari 2021 sebaran kasus positif Covid-19 di Indonesia mencapai 927.000 dengan pasien sembuh sebanyak 754.000 dan pasien meninggal dunia 26.590. Sedangkan di Tulungagung sendiri total kasus pada tanggal 19 Januari 2021 sebanyak 1850 pasien terkonfirmasi positif Covid-19, dengan kasus positif sebanyak 191 kasus di Kec. Boyolangu. Tujuan kegiatan ini adalah memberikan pembekalan dan pembuatan hand sanitizer menggunakan campuran ekstrak daun sirih kepada warga desa Ngranti Kecamatan Boyolangu. Adapun kegiatan berupa pelatihan singkat dan diskusi bersama warga. Hasil evaluasi kegiatan menunjukkan peningkatan pengetahuan dan kemampuan sebanyak 62,8% pada warga desa Ngranti tentang pengetahuan dan pembuatan hand sanitizer menggunakan ekstrak daun sirih. Kata Kunci: covid-19, hand sanitizer, daun sirih, warga desa.  ABSTRACT COVID-19 has become a world health problem. WHO officially declared it a pandemic on March 11, 2020. Based on data from the Covid-19 Task Force on January 19, 2021, the distribution of positive cases of Covid-19 in Indonesia reached 927,000 with 754,000 recovered patients and dead patients. world 26,590. While in Tulungagung itself, the total number of cases on January 19, 2021 was 1850 patients who were confirmed positive for Covid-19, with 191 positive cases in Kec. Boyolangu. The purpose of this activity is to provide debriefing and manufacture of hand sanitizer using a mixture of betel leaf extract to Nganti villagers, Boyolangu District. The activities are in the form of short training and discussions with residents. The result of the evaluation of activities showed The results of the activity evaluation showed an increase in knowledge and abilities as much as 62.8% of Ngranti villagers about knowledge and making hand sanitizers using betel leaf extract. Keywords: covid-19, hand sanitizer, betel leaf, villagers.
Edukasi Manajemen Inkontinensia Urine pada Lansia
Authors: Hapipah Hapipah , Fatmawati Baiq Ruli , Nadrati Bahjatun , Istianah Istianah , Azhari Abdul Aziz
Published: April 2022

ABSTRAK Lansia adalah seseorang yang mengalami tahap akhir dalam perkembangan hidup manusia. Pada masa lansia, terjadi banyak perubahan dan penurunan fisiologi pada semua sistem tubuh. Inkontinensia urine merupakan salah satu keluhan yang banyak ditemui dan dialami oleh lansia yang disebabkan oleh penurunan kapasitas kandung kemih dan berkurangnya kemampuan otot lurik pada uretra karena perubahan fisiologi pada lansia. Penatalaksanaan inkontinensia urine dapat diupayakan lebih baik, sehingga kualitas ADL (Activity Daily Living) dapat dipertahankan dan meringankan beban yang ditanggung oleh keluarga yang merawat salah satunya dengan cara memberikan edukasi. Tujuan pengabdian kepada masyarakat ini diharapkan dapat memberikan edukasi kepada lansia dan keluarganya tentang manajemen inkontinensia urine di desa Mambalan dusun Baturiti kecamatan Gunung Sari, Lombok Barat. Metode yang digunakan dalam pengabdian ini adalah ceramah, diskusi dan demonstrasi dengan media laptop, LCD dan leaflet. Hasil dari kegiatan ini didapatkan para peserta menunjukkan sikap yang positif selama mengikuti kegiatan pengabdian dari awal sampai akhir. Perlu diadakan penyuluhan kesehatan secara berkelanjutan pada lansia agar tercapai kehidupan lansia yang sehat, sejahtera dan bahagia bersama keluarga. Kata Kunci: Edukasi, Inkontinensia Urine, Lansia  ABSTRACT Elderly is someone who is experiencing the final stage in the development of human life. In the elderly, there are many changes and physiological decline in all body systems. Urinary incontinence is one of the most common complaints experienced by the elderly caused by decreased bladder capacity and reduced ability of the striated muscles in the urethra due to physiological changes in the elderly. The management of urinary incontinence can be strived to be better, so that the quality of ADL (Activity Daily Living) can be maintained and ease the burden borne by families who care for one of them by providing education. The purpose of this community service is expected to be able to provide education to the elderly and their families about urinary incontinence management in Mambalan village, Baturiti hamlet, Gunung Sari sub-district, West Lombok. The methods used in this service are lectures, discussions and demonstrations using laptop, LCD and leaflet media. The results of this activity showed that the participants showed a positive attitude during the service activities from beginning to end. It is necessary to hold ongoing health education for the elderly in order to achieve a healthy, prosperous and happy life for the elderly with their families. Keywords: Heatlh Education, Urinary Incontinence, Elderly
Pemberdayaan Kader dalam Meningkatkan Penggunaan Alat Kontrasepsi IUD di Puskesmas Sako Kota Palembang
Authors: Pastuty Rosyati , Komariah Nurul , Wilma Wilma , Hendawati Hendawati
Published: April 2022

ABSTRAK  Indonesia merupakan negara ke empat di dunia dengan jumlah penduduk terbanyak. Program KB semakin banyak PUS yang menggunakan MKJP maka, program untuk mengatasi masalah penduduk seperti meledaknya penduduk akan berhasil atau setidaknya dapat sedikit teratasi. Ibu yang berpengetahuan baik cenderung akan memilih kontrasepsi IUD. Kader sangat berperan salah-satunya pada untuk memotivasi penggunaan Kontrasepsi IUD. Tujuan Kegiatan Pengabmas ini Meningkatkan pengetahuan kader tentang penggunaan alat kontrasepsi IUD. Pelaksanaan kegiatan pengabdian pada masyarakat dilakukan dengan metode FGD dengan Kelompok FGD dibagi dalam 2 kelompok, masing-masing kelompok terdiri dari 12 orang kader dari posyandu yang berbeda.FGD dilaksanakan selama ±60 menit, yang dimulai dengan pembukaan, perkenalan dan penyampaian maksud dan tujuan diadakannya kegiatan serta dilanjutkan dengan pelaksanaan FGD disetiap kelompok. Setiap kelompok di pimpin oleh 1 orang fasilitator dan 1 orang transkiper (pencatat) dan 1 orang yang bertugas mendokumentasikan kegiatan. Tidak ada kendala yang menghambat pada saat pelaksanaan FGD karena peserta sangat aktif dalam berdiskusi. Semua kader memberikan pendapat dengan bebas, tanpa rasa takut atau segan, serta tetap fokus terhadap topik yang didiskusikan. Kata Kunci: FGD, IUD, Kader, Pengetahuan.  ABSTRACT  Indonesia is the fourth country in the world with the largest population. There are more family planning programs that use MKJP, so the program to overcome population problems such as population explosion will be successful or at least can be solved a little. Mothers who have good knowledge tend to choose IUD contraception. Cadres play a very important role, one of which is to motivate the use of IUD Contraception. The purpose of this Community Service Activity was to increase the knowledge of cadres about the use of IUD contraceptives. The implementation of community service activities was carried out using the FGD method with the FGD groups divided into 2 groups, each group consisting of 12 cadres from different posyandu. activities and continued with the implementation of FGDs in each group. Each group was led by 1 facilitator and 1 transkiper and 1 person in charge of documenting activities. There were no obstacles that hindered the implementation of the FGD because the participants were very active in discussing. All cadres give their opinions freely, without fear or reluctance, and stay focused on the topics discussed. Keyword: FGD, IUD, Cadre, Knowledge.
Edukasi Menjaga Kesehatan Telinga dan Pemeriksaan Telinga pada Anak Panti Asuhan di Desa Rimbo Panjang, Kecamatan Tambang, Kabupaten Kampar
Authors: Yolazenia Yolazenia , Asmawati Asmawati , Ulfa Loriana
Published: April 2022

ABSTRAK Kesehatan telinga yang tidak dijaga dengan baik, dapat menyebabkan gangguan pendengaran. Gangguan pendengaran pada anak dapat menyebabkan sulit berkomunikasi dan menerima pelajaran sehingga prestasi menurun. Kegiatan ini bertujuan memberikan pengetahuan mengenai menjaga kesehatan telinga dan melakukan pemeriksaan telinga. Kegiatan dilakukan di Panti Asuhan Baiturrahmah yang berlokasi di Desa Rimbo Panjang, Kecamatan Tambang, Kabupaten Kampar, Riau. Kegiatan diawali dengan memberikan penyuluhan mengenai menjaga kesehatan telinga dilanjutkan dengan pemeriksaan telinga. Kegiatan diikuti oleh 42 orang anak. Sebelum dan sesudah penyuluhan diberikan pre dan post test dengan hasil  rata-rata 46,67 dan 70,48, terdapat peningkatan pengetahuan yang signifikan pada anak mengenai kesehatan telinga. Dari hasil pemeriksaan didapatkan 15 orang anak dengan serumen baik pada satu atau kedua telinga diantaranya 3 orang berupa serumen prop, dan 1 orang terdapat benda asing semut di liang telinga. Melalui kegiatan ini terdapat peningkatan pengetahuan dari anak-anak penghuni panti asuhan mengenai cara menjaga kesehatan telinga dan memiliki telinga yang lebih bersih dan sehat setelah dilakukan pemeriksaan. Kata kunci: panti asuhan, pendengaran, serumen, telinga  ABSTRACT Ear health if not maintained properly, can cause hearing loss. Hearing loss in children can cause difficulties in communicating and receiving lessons so that achievement decrease. The aims of this activity was to provide knowledge about ear health and conduct ear examinations. The activity was carried out at the Baiturrahmah Orphanage located in Rimbo Panjang Village, Tambang District, Kampar Regency, Riau. The activity began with providing counseling on how to maintain ear health followed by ear examination. This activity was attended by 42 children living in the orphanage. Before and after being given education we provided pre and post test with the average result 46.67 and 70.48, there was a significant increase in children's knowledge about ear health. From the results of the examination, it was found that 15 children had cerumen in one or both ears, including 3 in the form of cerumen prop, and 1 person with a foreign body ants in the ear canal. Through this activity there was an increase in the knowledge of the children living in the orphanage about how to maintain healthy ears and have cleaner and healthier ears after the examination. Keywords: cerumen, ear, hearing, orphanage
Percepatan Program Vaksinasi Covid-19 Demi Terwujudnya Herd Immunity di Wilayah Kerja Puskesmas Matraman, Jakarta Timur
Authors: Widowati Lorensia Panselina , Manungkalit Eviyani Margaretha , Dewi Ni Nyoman Sri Artina , Suhaid Dewi Novitasari , Wardani Dyah Woro Kartiko Kusuma , Ides Stefanus Andang
Published: April 2022

ABSTRAK Vaksinasi merupakan salah satu langkah yang dapat dilakukan untuk memutus mata rantai penyebaran Covid-19. Dengan meningkatnya kekebalan tubuh manusia terhadap virus ini, diharapkan akan terjadi penurunan jumlah kasus dan bila pun terinfeksi, maka gejala yang ditimbulkan akan lebih ringan dibandingkan bila tidak divaksin. Tujuan kegiatan ini adalah untuk mempercepat pemerataan program vaksinasi Covid-19 di wilayah Matraman, Jakarta Timur. Kegiatan ini diawali dengan persiapan hal teknis termasuk SDM kesehatan dan tenaga penunjang, vaksin dan alat medis serta penyebaran informasi ke masyarakat secara masif. Sebanyak 2362 warga mendapatkan vaksinasi dosis pertama dan kedua dalam kegiatan ini. Dengan semakin banyaknya masyarakat yang mendapatkan vaksinasi, diharapkan herd immunity dapat segera terbentuk dan mengurangi transmisi penyebaran Covid-19. Kata Kunci: Vaksinasi, Covid-19, Herd Immunity ABSTRACT Vaccination is one of the steps to break the chain of Covid-19’s spread in society. The increased human body's immunity to this virus could reduce the number of cases. Even though we’re infected, the symptoms will be milder than those who have not been vaccinated yet. The purpose of this activity was to accelerate the distribution of the Covid-19 vaccination program in the Matraman area, East Jakarta. It began with the technical preparation including health human resources and supporting personnel, vaccines, and medical devices. We also did massive persuasive information to the community. A total of 2362 residents received the first and second doses of vaccination in this activity. As more and more people are getting vaccinated, we can achieve herd immunity faster and the transmission of Covid-19 can be reduced. Keywords: Vaccination, Covid-19, Herd Immunity
Dukungan Keluarga Dengan Tingkat Kecemasan Pada Pasien Yang Terkonfirmasi Covid-19 Di Kerja Puskesmas Teluk Pucung Bekasi Utara
Authors: Pradika Teo Bangun , Listyorini Meria Woro
Published: April 2022

ABSTRACT Patients who are confirmed positive for Covid 19, 75% will feel anxious or afraid to undergo treatment because they have to be separated from family members. This research is for family support has a very important role in reducing the anxiety of C0VID-19 patients who are undergoing treatment. This thesis discusses the relationship between family support and anxiety levels in patients with confirmed COVID-19 in the Teluk Pucung Health Center, North Bekasi. This research is quantitative research with cross sectional design . The study found a relationship between family support and anxiety levels in patients with confirmed COVID-19 in the Teluk Pucung Health Center, North Bekasi, with a p value of 0.019 <0.05. This study suggests that nurses who serve in the Teluk Pucung Health Center Work Area can provide motivation and support to patients by asking the patient's family to call and continue to monitor the patient's development status while undergoing treatment for COVID-19 patients so that patients can help reduce patient anxiety and improve the patient's immune system. Keywords: Family Support, Anxiety Level ABSTRAK Pasien yang terkonfirmasi positif Covid 19, 75% akan merasakan cemas atau takut untuk menjalai pengobatan karena harus berpisah dengan anggota keluarga. Penelitian ini untuk  Dukungan keluarga mempunyai peranan yang sangat penting dalam mengurangi kecemasan pasien C0VID-19 yang sedang menjalani perawatan. Skripsi ini membahas tentang hubungan dukungan keluarga dengan tingkat kecemasan pada pasien yang terkonfirmasi COVID-19 di Wilayah Kerja Puskesmas Teluk Pucung Bekasi Utara. Penelitian ini adalah penelitian kuantitatif dengan desain cross sectional. Penelitian didapatkan hubungan antara dukungan keluarga dengan tingkat kecemasan pada pasien yang terkonfirmasi COVID-19 di Wilayah Kerja Puskesmas Teluk Pucung Bekasi Utara dengan nilai p value 0,019 < 0,05. Penelitian ini menyarankan agar perawat yang berdinas di Wilayah Kerja Puskesmas Teluk Pucung dapat memberikan motivasi dan support terhadap pasien dengan cara meminta keluarga pasien untuk menelphone dan memantau terus status perkembangan pasien selama menjalani perawatan pasien COVID-19 sehingga pasien dapat membantu mengurangi kecemasan pasien dan meningkatkan sistem imun pasien. Kata Kunci: Dukungan keluarga, Tingkat kecemasan
Racializing Apparatuses and Embodiment Performance
Authors: Oh Hyeongjin
Published: April 2022

In April 2014, a ship named Sewol, carrying 476 passengers on its way to Jeju Island, sank into the Yellow Sea, near South Korea. The shipwreck exposed the Park administration’s incapacity to save civilians and ignited a huge political scandal that eventually impeached and imprisoned the President. In this paper, I centrally discuss two ways of performance art’s embodiment of the actual/imagined body of its subjects through stage devices (the prosthetic) and reconstruction of the audience’s sense of temporality (the stage as temporal indicator), by examining a South Korean performance piece’s engagement with the navigational failure and the systematic racialization of Southeast Asian immigrants by multiculturalist art policies and apparatuses.
Art & Oceania: Case Studies
Authors: Brohm Megan , Campbell Rowyn , Isikdemir Sibel , Theleritis Dina , Yermolina Anna , Zhou Yang , Koch Charlotte , Myburgh B.
Published: April 2022

These case studies were produced for FAH489: Art &Oceania, instructor Brittany Myburgh.This course offered an introduction to the history of art produced within Oceania from prehistory to present day. The Pacific Ocean (The Great Ocean/Te Moana Nui a Kiwa) spans a vast geographic territory. Through central ideas of navigation and migration, the course explored the important role of connectivity, mobility, and exchange in Oceanic art and visual culture. Participating Authors: Megan Brohm, Rowyn Campell, Sibel Isikdemir Charlotte Koch, Dina Theleritis, Anna Yermolina, Yang Zhou
The Necessity of Clarification of Basic Accounting Concepts and Development of Ukrainian Accounting Theory
Authors:   Zhytomyr Polytechnic State University, Zhytomyr, Ukraine, Lehenchuk Serhii
Published: April 2022

In recent years, a systemic crisis has been observed in Ukraine in accounting theory. It manifests itself in the absence of deep scientific research and the development of new teaching aids for the course “Theory of accounting”, which would meet the requirements of the time and consider the current state of development of the national accounting system. The purpose of the article is to analyze the differences in basic accounting concepts in different models of accounting theory, and identify problems and directions for the development of accounting theory in Ukraine. The role of legislative documents in the formation of theoretical foundations of accounting has been disclosed. Three main models of understanding accounting theory in Ukraine (national normative; normative according to IFRS; educational accounting theory) have been allocated. Peculiarities of origin and content characteristics of each of the selected models have been analyzed. Three areas of research conducted by scientists in the field of accounting theory have been allocated. The lack of clearly defined conceptual proposals among scientists for further development of accounting theory in Ukraine has been grounded. Based on the analysis of normative legislation, the problem of lack of common understanding of basic accounting concepts (business transactions; actions; events) has been identified. Three options for the relation between basic accounting concepts have been allocated. Two main problems have been formulated, which arise due to the existence of a multivariate understanding of the essence and correlation between basic accounting concepts (content-classification problem; the problem of content-time interpretation). Examples of incorrect interpretations of basic accounting concepts by national and foreign scientists have been given. The peculiarities of the relation between basic accounting concepts in the Conceptual Framework for the Financial Reporting and IFRS have been analyzed. The peculiarities of the interpretation of basic accounting concepts according to SFAC no. 6 “Elements of financial statements” have been grounded. The necessity of making changes in the national accounting legislation to clarify the content and correlation between basic accounting concepts has been grounded. In response to modern changes in the economic reality of enterprises and the system of accounting regulation, it has been proposed to develop the national accounting theory by increasing the number of elements of the accounting method, in particular, by including the object identification to the elements of accounting method.
Treatment-free remission in chronic myeloid leukemia patients treated front-line with nilotinib: 10-year followup of the GIMEMA CML 0307 study
Authors: Gugliotta Gabriele , Castagnetti Fausto , Breccia Massimo , Levato Luciano , Intermesoli Tamara , D'Adda Mariella , Salvucci Marzia , Stagno Fabio , Rege-Cambrin Giovanna , Tiribelli Mario , Martino Bruno , Bocchia Monica , Cedrone Michele , Trabacchi Elena , Cavazzini Francesco , Porretto Ferdinando , Sorà Federica , Simula Maria Pina , Albano Francesco , Soverini Simona , Foà Robin , Pane Fabrizio , Cavo Michele , Saglio Giuseppe , Baccarani Michele , Rosti Gianantonio
Published: April 2022

We report the final analysis, with a 10-year follow-up, of the phase II study GIMEMA CML 0307 (NCT 00481052), which enrolled 73 adult patients (median age 51 years; range, 18-83) with newly diagnosed chronic-phase chronic myeloid leukemia to investigate the efficacy and the toxicity of front-line treatment with nilotinib. The initial dose was 400 mg twice daily; the dose was reduced to 300 mg twice daily as soon as this dose was approved and registered. The 10-year overall survival and progression- free survival were 94.5%. At the last contact, 36 (49.3%) patients were continuing nilotinib (22 patients at 300 mg twice daily, 14 at lower doses), 18 (24.7%) patients were in treatment-free remission, 14 (19.2%) were receiving other tyrosinekinase inhibitors and four (5.5%) patients have died. The rates of major and deep molecular responses by 10 years were 96% and 83%, respectively. The median times to major and deep molecular response were 6 and 18 months, respectively. After a median duration of nilotinib treatment of 88 months, 24 (32.9%) patients discontinued nilotinib while in stable deep molecular response. In these patients, the 2-year estimated treatment-free survival was 72.6%. The overall treatment-free remission rate, calculated on all enrolled patients, was 24.7% (18/73 patients). Seventeen patients (23.3%), at a median age of 69 years, had at least one arterial obstructive event. In conclusion, the use of nilotinib front-line in chronic phase chronic myeloid leukemia can induce a stable treatment-free remission in a relevant number of patients, although cardiovascular toxicity remains of concern.
The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodies
Authors: Vayne Caroline , Palankar Raghavendra , Billy Sandra , Handtke Stefan , Thiele Thomas , Cordonnier Charlotte , Pouplard Claire , Greinacher Andreas , Gruel Yves , Rollin Jérôme
Published: April 2022

In order to improve the safety of COVID-19 vaccines, there is an urgent need to unravel the pathogenesis of vaccineinduced immune thrombotic thrombocytopenia (VITT), a severe complication of recombinant adenoviral vector vaccines used to prevent COVID-19, and likely due to anti-platelet factor 4 (PF4) IgG antibodies. In this study, we demonstrated that 1E12, a chimeric anti-PF4 antibody with a human Fc fragment, fully mimics the effects of human VITT antibodies, as it activates platelets to a similar level in the presence of platelet factor 4 (PF4). Incubated with neutrophils, platelets and PF4, 1E12 also strongly induces NETosis, and in a microfluidic model of whole blood thrombosis, it triggers the formation of large platelet/leukocyte thrombi containing fibrin(ogen). In addition, a deglycosylated form of 1E12 (DG-1E12), which still binds PF4 but no longer interacts with Fcγ receptors, inhibits platelet, granulocyte and clotting activation induced by human anti-PF4 VITT antibodies. This strongly supports that 1E12 and VITT antibodies recognize overlapping epitopes on PF4. In conclusion, 1E12 is a potentially important tool to study the pathophysiology of VITT, and for establishing mouse models. On the other hand, DG-1E12 may help the development of a new drug that specifically neutralizes the pathogenic effect of autoimmune anti-PF4 antibodies, such as those associated with VITT.
Cholelithiasis and its Relationship with Serum Lipids in a Tertiary Care Hospital of Rajshahi
Authors: Saha Gobinda Chandra , Dhali Dipayan Kumar , Rashid Md Shoeb Ur , Dey Debashis , Al Mamun Md Hasib , Chhanda Chhamita Sultana
Published: April 2022

Background: Gallstone disease (GD) is one of the most prevalent gastrointestinal disease in worldwide and also in Bangladesh. High triglyceride and low HDL (high density lipoprotein) are associated with cholelithiasis whereas total cholesterol and LDL (low density lipoprotein) have less association.

Objectives: To find out the association of cholelithiasis and lipid profile.

Material and Methods: This case-control study was conducted on 300 patients in the department of surgery, Rajshahi Medical College Hospital from September, 2018 to August, 2019. Participants were divided into two groups; group A (case group- 150 patients) and group B (control group-150 patients). After overnight fasting 5 ml venous blood was collected and serum lipid profile was measured. Outcomes were expressed in the form of figures and tables.

Result: The mean age in case group were 39.79±8.16 years and in control group 38.67±7.99 years respectively with female predominance (72%) and male to female ratio was 1:2.57. out of 150 participants in case group 61% (91) had cholesterol stone. TG level was high both in cholesterol stone 57 (62.62%) and mixed stone 35 (59.32%) in case group. The mean BMI (25.73±2.10) in case group were significantly higher. Post-operative histopathology shown 2 (1.33%) patients associated with malignancy.

Conclusion: The increased lipid profile can be good indicator for gall stone diseases and female are more susceptible to form gallstone who have high cholesterol level. Obesity is a risk factor for gallstone so people should maintain an ideal body weight. Gallstones are predisposing factor for malignancy.

Sir Salimullah Med Coll J 2021; 29(2): 95-99
Comparative Evaluation of Quantitative Protein Measurement of 12-Hour and 24-hour Urine Sample for the Diagnosis of Nephrotic Syndrome and their Correlation with Spot Urinary Protein Creatinine Ratio
Authors: Sarker Aditi , Banu Nazneen Akhter , Sultana Naima , Nesa Vikarun
Published: April 2022

Background: The amount of protein excretion is a reflection of disease activity in Nephrotic Syndrome. 24-hour urine collection has remained as the method of choice to quantify proteinuria. An alternative method for quantitative evaluation of proteinuria is measuring the ratio of protein or albumin to creatinine in an untimed ‘‘spot’’ urine specimen.

Objective: To compare 12-hour versus 24-hour proteinuria in nephrotic syndrome and its correlation to spot urinary protein creatinine ratio.

Materials & Methods: A comparative cross-sectional study was conducted in the Department of Pediatrics, Sir Salimullah Medical College Mitford Hospital (SSMC & MH), Dhaka over a period from September 2016 to June 2017. All the babies developing 1st attack of Nephrotic Syndrome and meeting the clinical criteria were included in the study. Complete history was taken from accompanying attendants. Thorough clinical examinations and relevant laboratory investigations (12- hour day urinary protein, 12-hour night urinary protein, 24-hour urinary total protein, S. Albumin, S. Cholesterol, Urinary spot Protein Creatinine ratio) were done. All the information was recorded in the fixed protocol. Collected data were classified, edited, coded and entered into computer for statistical analyses.

Results: Out of 50 cases, the mean age was found 58.3±29.0 months. 12-hour day urinary protein was found 2.02±0.167 gm/m2/12 hours, mean; 12-hour night urinary protein was found 2.12±2.18 gm/m2/12 hours, mean; 24-hour urinary total protein was found 4.10±3.32 gm/m2/24 hours. The mean spot urinary protein creatinine ratio was found 12.58±7.21 with range from 2.02 to 29.85. There was no statistically significant difference between 12- hour day sample and 12-hour night sample. There was also no significant difference between 12-hour day & night sample with 24-hour sample. Results of all 03 samples were comparable to urinary protein creatinine ratio.

Conclusion: This study reveals no statistically significant difference in quantitative estimation of 12-hour day and night protein with 24-hour urinary total protein. The 12- hour day and night protein and urinary total protein were comparable with each other and also with urinary spot protein creatinine ratio.So 12-hour day or night urinary total protein may be a diagnostic tool for nephrotic syndrome.

Sir Salimullah Med Coll J 2021; 29(2): 105-111
Solid Tumor in Children: A Single Centre Experience
Authors: Laz Mafia Afshin , Islam Md Mazidul , Yamin Kaisar , Jafor Md Abu , Hossain Md Monowar , Boksh Sheikh Zahid , Hai AHM Abdul
Published: April 2022

Introduction: Now a days, number of childhood tumors are gradually increasing throughout the world. But in Bangladesh we have no actual tumor register. In this study we just try to find out the demographic presentation of solid tumor in a tertiary care center of Dhaka city.

Methods and materials: it is a retrospective descriptive type of observational study. Study was held in department of pediatric surgery, Sir Salimullah medical college Mitford hospital Dhaka from January 2016 to December 2020.

Results: total number of the patients were 37. Male 15 and female 22. Male female ratio is 1:1.7. Age range of the patients from 9 days to 13 years. Mean age 135.83 days. Among 37 patients, 29 had malignant tumors and rest of 8 patients had benign tumor. Ovarian tumors were highest, 10. Then nephroblastoma 9, neuroblastoma 7, non Hodgkin lymphoma 3, sacrococcygeal teratoma 3, adrenal benign tumor 1, soft tissue sarcoma in pelvis 1, rhabdomyosarcoma of urinary bladder1, rectal carcinoma 1 and rhabdomyosarcoma of lower limb 1 accordingly. Most of the patients were went through surgery first then sent for chemotherapy according to histology.

Conclusion: In spite of a tertiary medical care center in Dhaka city, our number of patient is not satisfactory. Lack of proper awareness in public, lots of patient did not reach to proper center, those who attained hospital, may lost. And our poor record keeping system is also responsible for adequate informations.

Sir Salimullah Med Coll J 2021; 29(2): 117-120
Expression of p63 in Cervical Intraepithelial Neoplasia (CIN) and Cervical Cancer
Authors: Das Reba , Mouri Mahfuza Jebun , Mir Ratim , Begum Shahnaj , Mudi Nondita , Kabir Enamul
Published: April 2022

Background: Cervical cancer is a major public health problem worldwide. Persistent infection with High-Risk Human Papilloma Virus (HPV) has been the main cause of squamous intraepithelial neoplasia which in turn leads to invasive squamous cell carcinoma. p63 is necessary for the activation of HPV, epithelial proliferation and differentiation. It also regulates the expression of certain cell cycle regulators. It has been reported that, from CIN I to CIN III, p63 expression increases progressively from basal layer to surface. In squamous cell carcinoma, it is expressed throughout the entire thickness of the tumor. Thereby it plays a significant role in diagnosing cervical premalignant and malignant lesions.

Objective: To evaluate the relationship of p63 expression with different grades of CIN & invasive SCC.

Method: Total 86 paraffin embedded tissue blocks of histopathologically diagnosed cases of CIN and cervical cancer were evaluated by immunohistochemical staining for p63 expression. The study was performed in Sir Salimullah Medical College, Dhaka (from March, 2018 to February, 2020). Statistical analyses were carried out by using SPSS version 22 for Windows. A descriptive analysis was performed for all data. Observations were indicated by frequencies and percentages. Statistical significance was set at “p” value <0.05.

Results: Present study showed progressive increase in p63 expression from CIN I to CIN III from basal layer to surface. In invasive squamous cell carcinoma, higher expression of p63 was noted throughout the entire thickness of the tumor. No expression was seen in cervical adenocarcinoma and small cell carcinoma. In adenosquamous carcinoma only the area showing squamous differentiation revealed positive p63 expression. Statistically significant association of p63 expression was found with parity of patients and among grades of CIN .

Conclusion: The results of this current study revealed that, p63 has significant association among different grades of CIN. It is also a useful marker in confirming a poorly differentiated squamous cell carcinoma & predicting the progression of a squamous neoplastic lesion from cervical intraepithelial neoplasia to invasive squamous cell carcinoma. Moreover, it is useful to differentiate invasive squamous cell carcinoma from cervical adenocarcinoma.

Sir Salimullah Med Coll J 2021; 29(2): 141-146
Aetiology and Outcome of Resection and Primary Anastomosis in Multiple Ileal Perforation
Authors: Saha Gobinda Chandra , Azam Md Ali , Rashid Md Shoeb Ur , Dey Debashis , Begum Muslema , Mamun Md Hasib Al , Chhanda Chhamita Sultana
Published: April 2022

Background: Ileal perforation is a very frequent surgical emergency in surgery wards. In tropical country infection is the commonest cause. Repair of perforation, primary repair with loop ileostomy and resection and primary anastomosis are the commonly performed methods.

Objectives: To identify the aetiology and assess the outcome of resection and primary anastomosis in multiple ileal Perforation.

Study Procedure: This Quasi experimental study was carried out in the Department of Surgery, Rajshahi Medical College Hospital, Rajshahi. 92 patients were included in this study. Thorough clinical, Radiological and biochemical parameters evaluation with postoperative histopathology were performed. All patients treated with resection and primary anastomosis. Different types of Data and variables were recorded through data collection sheet. Mean and frequency of all quantitative and categorical variables were determined.

Results: The mean age 42.60±4.44 (age range:18-69) years. Out of 92 patients 74(80.43%) were male and 18(19.56%) were female and ratio was 4.11:1.Presentation were 92(100%) abdominal pain, vomiting 74(80.43%), fever 60(65.21%) and abdominal distension 56(60.86%). Common Cause were typhoid fever 43(46.73%) and nonspecific inflammation 28(30.43%). Patient suffered from wound infection 18(19.44%), dehiscence 7(7.56%), anastomosis leakage 6(6.68%) and 5(5.43%) patient experienced incisional hernia. 74(80.43%) recovered uneventfully, 17(18.47%) recovered with complication and only 1(1.08%) died.

Conclusion: Among the infections, typhoid fever is still the prime cause of multiple ileal perforation. Wound infection, wound gap, burst abdomen & primary repair leakage are the common complications. Uneventful outcome is present in majority cases. Delayed presentation, nutritional status and anastomosis from ileocaecal valve are the important deciding factor of worst outcome.

Sir Salimullah Med Coll J 2021; 29(2): 153-157
Integration of PSO and Clustering algorithms for privacy preserving data mining
Authors: Eh Chonga Shorayha , Md. Siraj Maheyzah , Rahmat Nurul Adibah , Din Mazura Mat
Published: April 2022

Privacy Preserving Data Mining (PPDM) currently has become an important research area. There are some issues and problems related to PPDM have been identified. Information loss occurs when the original of data is modified to keep the privacy of those data. Effects of PPDM also cause the level of data quality to become lower. The aim of this research is to minimize information loss and increase the accuracy of mining result while maintaining the privacy level of data. A randomization approach based on optimization and clustering algorithms is proposed in order to minimize the information loss and improve the accuracy of data clustering quality for PPDM results. There are three main objectives for this research which is to perform data pre-processing on data through the normalization process and k-Anonymity algorithm. The second objective is to minimize data loss and increase the accuracy of data mining result using Particle Swarm Optimization and clustering algorithms. The third objective is to evaluate and benchmark the performance measurement based privacy level and data quality of enhanced PPDM. Diabetes dataset is used in this research and all instances are a numerical value. The outcome of this research is the privacy level of the dataset was increased while the information loss is minimized. The experimental results also show that the accuracy of data clustering quality can be preserved with using PSO algorithm.
Konvergensi Media Dalam Program “After Hours with Helmy Yahya” di Inews
Authors: Oktavianingtyas Irmawati , Rusadi Udi
Published: April 2022

After Hours with Helmy Yahya is a talk show program produced by Inews TV, under the auspices of the MNC Group. But unfortunately, the program was terminated after airing for no more than 2 months. Convergence as a strategy for media companies to survive in the digital era has been applied to the program, but apparently, this does not affect the success of the program. Therefore, the author wants to know the application of media convergence in the "After Hours with Helmy Yahya" program and also to know the extent to which convergence contributes to the success of the program, especially in terms of the political economy of the media. The results of the study indicate that most of the program's income comes from After Hours with Helmy Yahya which is broadcasted via analog TV. It can be concluded that the convergence strategy has not contributed significantly to the success of the program, especially in terms of income for the company
PERAN BALAI LATIHAN KERJA KOTA PROBOLINGGO DALAM MENGURANGI PENGANGGURAN DIMASA COVID-19
Authors: Kristiyono Jefri Tri , Sucahyo Imam
Published: April 2022

In Probolinggo City because of this pandemic and also PPKM which rose to level 4 this has caused the rate of layoffs to increase this applies to job seekers due to policies from the government many companies disable companies and temporarily do not open job vacancies this causes an increase in unemployment in Probolinggo City This study aims to determine the role of the Probolinggo City Job Training Center to reduce unemployment during the pandemic. With this training, it is hoped that it will reduce unemployment due to this pandemic. The type of research used is qualitative research with a descriptive approach. The focus of the research discussion is the implementation of job training during the pandemic with 2 indicators, namely training methods and training objectives. The research was conducted at the Probolinggo City Job Training Center, with the interview method to collect data. The results of this research are that in the implementation of job training carried out by the Probolinggo City Job Training Center, it succeeded in reducing unemployment by applying 60% practice training methods, 40% theoretical training participants could Practicing what the training instructor teaches, the goal of the Probolinggo City Job Training Center is achieved by collaborating with PT Eratex, the participants are competent, one of which is sewing, modes can immediately get a job, this indicator has succeeded in reducing unemployment in the pandemic Di Kota Probolinggo  karena pandemi ini dan juga PPKM yang naik ke level 4 ini hal ini menyebabkan tingkat Pemutusan Hubungan Kerja meningkat hal ini berlaku untuk para pencari kerja dikarenakan kebijakan dari pemerintah banyak perusahaan menonaktifkan perusahaan dan sementara tidak membuka lowongan pekerjaan hal ini menyebabkan adanya peningkatan pengangguran di Kota Probolinggo Penelitian ini bertujuan untuk mengetahui peran Balai Latihan Kerja Kota Probolinggo untuk mengurangi pengangguran di masa pandemi. Deangan adanya pelatihan ini diharapkan bisa mengurangi adanya pengangguran karena adanya pandmei ini. .Jenis penelitian yang digunakan yaitu Penelitian Kualitatif dengan pendekatan Deskriptif. Fokus pembahasan penelitian yaitu pelaksanaan pelatihan kerja dimasa pandemi dengan 2 indikator yaitu Metode pelatihan dan tujuan pelatihan. Penelitian dilakukan di Balai Latihan Kerja Kota Probolinggo, dengan metode wawancara untuk mengambil data.Hasil Penelitian ini yaitu dalam pelaksanaan pelatihan kerja yang dilakukan pihak Balai Pelatihan Kerja Kota Probolinggo berhasil mengurangi pengangguran dengan penerapan metode pelatihan 60% praktek, 40% teori para peserta pelatihan bisa mempraktekkan apa yaang diajarkan oleh Instruktur platihan, tujuan Balai Latihan Kerja Kota Probolinggo tercapai dengan kerjasama dengan PT Eratex para peserta kompeten salah satunya kejuruan menjahit, modes bisa langsung mendapat pekerjaan indikator tersebut berhasil mengurangi pengangguran di pandemi
PENGARUH PANDEMI CORONAVIRUS DISEASE (COVID-19) TERHADAP PERKEMBANGAN PEREKONOMIAN PELAKU SENI DI KECAMATAN KOTAANYAR KABUPATEN PROBOLINGGO
Authors: Alfian Farhan , Nefo Bernadeta
Published: April 2022

Indonesia is one of the developing countries in Southeast Asia which has many islands, ethnic diversity and abundant natural resources that must be preserved. All countries including Indonesia are being hit by a virus from Wuhan, namely Corona Virus Disease-19, according to the Instruction of the Minister of Home Affairs Number 15 of 2021 concerning the Enforcement of Restrictions on Community Activities, which are urged to close workplaces and businesses, one of which is the affected sub-district, namely Kotaanyar District. This causes minimal income for the place of business which causes unemployment and layoffs in Kotaanyar District. The type of research used is descriptive research with a qualitative approach. The focus of the research discussion is the implementation of a new work system during a pandemic. The research was conducted in Kotaanyar District, with the interview method to collect data. The results of this study are that in implementing a new work system during this pandemic, village and sub-district governments have succeeded in overcoming people who have lost their jobs and lost income with the new work system during the pandemic, and it is hoped that this pandemic will end soon so that people can carry out their activities and work normally. return.Indonesia merupakan salah satu negara berkembang di Asia Tenggara yang memiliki banyak pulau, keanekaragaman suku bangsa dan sumber daya alam yang melimpah yang harus dilestarikan. Seluruh negara termasuk Indonesia sedang dilanda virus dari Wuhan yaitu Corona Virus Disease-19, menurut Instruksi menteri dalam negeri Nomer 15 tahun 2021 tentang Pemberlakukan Pembatasan Kegiatan Masyarakat yang dihimbau untuk menutup tempat kerja dan usaha salah satunya kecamatan yang terkena dampak yaitu Kecamatan Kotaanyar. Hal ini menyebabkan penghasilan tempat usaha minim yang menyebabkan pengangguran maupun adanya Pemutusan Hubungan Kerja di Kecamatan Kotaanyar. Jenis penelitian yang digunakan yaitu Penelitian Deskriptif dengan pendekatan Kualitatif. Fokus pembahasan penelitian yaitu pelaksanaan sistem kerja baru dalam masa pandemi. Penelitian dilakukan di Kecamatan Kotaanyar, dengan metode wawancara untuk mengambil data. Hasil Penelitian ini yaitu dalam pelaksanaan sistem kerja baru dalam masa pandemi ini pemerintah desa dan kecamatan sukses untuk mengatasi masyarakat yang kehilangan pekerjaan dan kehilangan pendapatan dengan adanya sistem kerja baru dalam masa pandemi, dan diharapkan pandemi ini segera berakhir agar masyarakat bisa beraktifitas dan bekerja secara normal kembali.