bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Outcomes among Hospitalized COVID-19 Patients Who Received Baricitinib or Tocilizumab in Addition to Standard of Care
Authors: Walker Cucnhat P. , Hurlock Natalie P. , Deb Subrata
Published: May 2024

COVID-19 infection is caused by the novel severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2). This novel virus has transformed into different resistant variants (e.g., omicron; delta; alpha; epsilon) since its first emergence in 2019. The National Institutes of Health and Infectious Diseases Society of America guidelines currently recommend adding either baricitinib or tocilizumab to the standard of care for severe COVID-19 treatment. An outcome comparison between baricitinib and tocilizumab is needed to determine which agent is more appropriate and safer in clinical practice when deciding treatment. We aimed to compare mortality and clinical outcomes between tocilizumab and baricitinib in the management of severe COVID-19 infection. A total of 5638 adult patients from 16 acute care hospitals in a large healthcare system in Texas were included in this multicentered retrospective cohort study. The median age of the patients was 56 years and 46.67% of them were female. Severe COVID-19 patients were treated with standard of care and either tocilizumab or baricitinib. The primary outcome of hospital admission mortality rates was found to be higher with tocilizumab (odd ratio (OR) of 1.56; p = 0.001; 95% CI 1.19 to 2.008) compared to that with baricitinib (OR 0.65; p = 0.001; 95% CI 0.50 to 0.84). For one of the secondary outcomes, patients who received tocilizumab were 3.75 times more likely to be admitted to the ICU than those receiving baricitinib (p = 0.001; 95% CI 2.89 to 4.85). Among the 1199 COVID-19 patients who were admitted to the ICU, the ICU length of stay was shorter among patients receiving baricitinib with a mean difference of 4.42 days and a median difference of 2.54 days, compared to those receiving tocilizumab (p < 0.0001; 95% CI −5.97 to −2.62) as another secondary outcome. Our large retrospective observational study showed that baricitinib reduced mortality; the likelihood of ICU admission; and the ICU length of stay compared to tocilizumab in patients with severe COVID-19 infection.
A Framework of Grasp Detection and Operation for Quadruped Robot with a Manipulator
Authors: Guo Jiamin , Chai Hui , Zhang Qin , Zhao Haoning , Chen Meiyi , Li Yueyang , Li Yibin
Published: May 2024

Quadruped robots equipped with manipulators need fast and precise grasping and detection algorithms for the transportation of disaster relief supplies. To address this, we developed a framework for these robots, comprising a Grasp Detection Controller (GDC), a Joint Trajectory Planner (JTP), a Leg Joint Controller (LJC), and a Manipulator Joint Controller (MJC). In the GDC, we proposed a lightweight grasp detection CNN based on DenseBlock called DES-LGCNN, which reduced algorithm complexity while maintaining accuracy by incorporating UP and DOWN modules with DenseBlock. For JTP, we optimized the model based on quadruped robot kinematics to enhance wrist camera visibility in dynamic environments. We integrated the network and model into our homemade robot control system and verified our framework through multiple experiments. First, we evaluated the accuracy of the grasp detection algorithm using the Cornell and Jacquard datasets. On the Jacquard dataset, we achieved a detection accuracy of 92.49% for grasp points within 6 ms. Second, we verified its visibility through simulation. Finally, we conducted dynamic scene experiments which consisted of a dynamic target scenario (DTS), a dynamic base scenario (DBS), and a dynamic target and base scenario (DTBS) using an SDU-150 physical robot. In all three scenarios, the object was successfully grasped. The results demonstrate the effectiveness of our framework in managing dynamic environments throughout task execution.
Correction: Bianchi et al. Quadrotor Trajectory Control Based on Energy-Optimal Reference Generator. Drones 2024, 8, 29
Authors: Bianchi Domenico , Borri Alessandro , Cappuzzo Federico , Di Gennaro Stefano
Published: May 2024

Figure corrections [...]
Hot Bridge-Wire Ignition of Nanocomposite Aluminum Thermite Synthesized Using Sol-Gel-Derived Aerogel with Tailored Properties for Enhanced Reactivity and Reduced Sensitivity
Authors: Ghedjatti Ilyes , Yuan Shiwei , Wang Haixing
Published: May 2024

The development of nano-energetic materials has significantly advanced, leading to enhanced properties and novel applications in areas such as aerospace, defense, energy storage, and automobile. This research aims to engineer multi-dimensional nano-energetic material systems with precise control over energy release rates, spatial distribution, and temporal and pressure history. In this context, sol–gel processing has been explored for the manufacture of nanocomposite aluminum thermites using aerogels. The goal is to produce nano-thermites (Al/Fe2O3) with fast energy release rates that are insensitive to unintended initiation while demonstrating the potential of sol–gel-derived aerogels in terms of versatility, tailored properties, and compatibility. The findings provide insightful conclusions on the influence of factors such as secondary oxidizers (KClO3) and dispersants (n-hexane and acetone) on the reaction kinetics and the sensitivity, playing crucial roles in determining reactivity and combustion performance. In tandem, ignition systems contribute significantly in terms of a high degree of reliability and speed. However, the advantages of using nano-thermites combined with hot bridge-wire systems in terms of ignition and combustion efficiency for potential, practical applications are not well-documented in the literature. Thus, this research also highlights the practicality along with safety and simplicity of use, making nano-Al/Fe2O3-KClO3 in combination with hot bridge-wire ignition a suitable choice for experimental purposes and beyond.
In Vitro Probiotic Characterization of Lactiplantibacillus plantarum Strains Isolated from Traditional Fermented Dockounou Paste
Authors: Kouadio Natia Joseph , Zady Alalet Luc Olivier , Kra Kouassi Aboutou Séverin , Diguță Filofteia Camelia , Niamke Sébastien , Matei Florentina
Published: May 2024

This study aimed to evaluate the probiotic properties of 10 lactic acid bacteria (LAB) isolated from artisanal fermented plantain dockounou paste. A preliminary characterization of the LAB isolates was performed based on phenotypic and several biochemical properties, which was subsequently confirmed through 16S rRNA gene sequencing analysis, indicating that these isolates belonged to the species Lactiplantibacillus plantarum. With regard to safety criteria, the strains exhibited no alpha or beta hemolysis activity. Nevertheless, the majority of LAB strains demonstrated high sensitivity to the antibiotics tested. The results demonstrated that the majority of the strains exhibited remarkably high survival rates under simulated gastrointestinal conditions, such as pH = 1.5 (81.18–98.15%), 0.3% bile salts (68.62–100.89%), 0.4% phenol (40.59–128.24%), as well as 0.1% pepsin and pH = 2.5 (88.54–99.78%). The LAB strains demonstrated elevated levels of cell surface properties, indicative of the presence of a considerable defensive mechanism against pathogens. Intact LAB cells exhibited significant antioxidant abilities (48.18–83.58%). They also demonstrated a pronounced inhibitory effect on the growth of foodborne pathogens. Enzyme pattern analysis revealed that the LAB isolates produced both proteases and cellulases, as well as pectinase and/or amylase activity. The potential of the L. plantarum strains FS43, FS44, and FS48, as indicated by the results obtained from the standard in vitro assays, makes them suitable for further study as potential probiotics.
Teamwork Conflict Management Training and Conflict Resolution Practice via Large Language Models
Authors: Aggrawal Sakhi , Magana Alejandra J.
Published: May 2024

This study implements a conflict management training approach guided by principles of transformative learning and conflict management practice simulated via an LLM. Transformative learning is more effective when learners are engaged mentally and behaviorally in learning experiences. Correspondingly, the conflict management training approach involved a three-step procedure consisting of a learning phase, a practice phase enabled by an LLM, and a reflection phase. Fifty-six students enrolled in a systems development course were exposed to the transformative learning approach to conflict management so they would be better prepared to address any potential conflicts within their teams as they approached a semester-long software development project. The study investigated the following: (1) How did the training and practice affect students’ level of confidence in addressing conflict? (2) Which conflict management styles did students use in the simulated practice? (3) Which strategies did students employ when engaging with the simulated conflict? The findings indicate that: (1) 65% of the students significantly increased in confidence in managing conflict by demonstrating collaborative, compromising, and accommodative approaches; (2) 26% of the students slightly increased in confidence by implementing collaborative and accommodative approaches; and (3) 9% of the students did not increase in confidence, as they were already confident in applying collaborative approaches. The three most frequently used strategies for managing conflict were identifying the root cause of the problem, actively listening, and being specific and objective in explaining their concerns.
Merits of Multi-Indicator Precautionary Approach Management in a Male-Only Crab Fishery
Authors: Mullowney Darrell , Baker Krista , Pantin Julia , Coffey William , Lefort Kyle , Morrissey Katie
Published: May 2024

Snow crab replaced groundfish fisheries as the primary focus of the Newfoundland and Labrador (NL) fishing industry in the mid-1990s. Over the past three decades, management philosophies in this male-only fishery have shifted from promoting industry expansion to promoting industry rationalization to implementing Precautionary Approach (PA) management. Until the mid-2010s, there were regionalized management strategies characterized by higher exploitation rates in northern than southern sub-stock units along the NL marine shelves. However, in the late 2010s, exploitation rates were permitted to elevate to high levels across the entire stock range in association with a large resource decline, and evidence of biological harm through fishing emerged in chronically depleted areas. In 2019, when stock and fishery productivity were near historical lows, a multi-indicator PA system was informally introduced into the management of the resource. This event coincided with anticipated improvements in stock and fishery performance. This paper examines the extent to which the multi-indicator PA management system, focused on the promotion of both biological protection and maximization of fishing efficiency, may have contributed to recent improvements in stock and fishery status. A suite of indicators from areas implementing PA guidance into management in 2019 prior to the formal adoption of the PA system in 2023 suggest the system has been highly beneficial in promoting rapid recovery and improving stock and fishery performance metrics to levels matching or exceeding historical levels under similar conditions. We discuss the capacity of the system to better safeguard biological aspects of resource and fisheries productivity moving forward under a scenario of an expectant resource decline.
Isolation, Characterization, and Pathogenicity of an Aeromonas veronii Strain Causing Disease in Rhinogobio ventralis
Authors: Wu Xingbing , Cheng Baolin , Xue Mingyang , Jiang Nan , Li Xuemei , Hu Xiaona , Li Xiaoli , Zhu Tingbing , Zhu Yongjiu , Zhou Yong
Published: May 2024

Rhinogobio ventralis is a rare fish found in the Yangtze River in China and has significant ecological and economic value. In this study, a bacterial strain (RV-JZ01) was isolated from the livers of diseased R. ventralis. This isolate was identified as Aeromonas veronii based on its morphology, biochemical features and 16S rDNA phylogenetic analysis. The artificial infection of healthy R. ventralis (16 ± 2 cm) with RV-JZ01 resulted in the manifestation of clinical symptoms, in accordance with those of naturally infected fish. The 50% lethal dose (LD50) of RV-JZ01 for R. ventralis was 6.3 × 106 CFU/mL. Histopathological examination revealed various pathological changes in the diseased fish, including intestinal villus swelling and rupture, hepatocyte vacuolization, renal tubular cell nuclear enlargement and pyknosis, and myocardial fiber fracture and atrophy. RV-JZ01 infection significantly reduced the gut flora diversity of R. ventralis, with the relative abundances of Firmicutes and Fusobacteria increasing, and those of the Proteobacteria and Bacteroidetes decreasing. The abundance of Lactobacillus and Streptococcus dramatically increased, and the abundance of Clostridium and Escherichia reduced in the intestinal microbiota of R. ventralis infected with RV-JZ01. Antibiotic sensitivity testing revealed that RV-JZ01 was highly susceptible to 12 antimicrobials, including erythromycin, cefalexin, norfloxacin, furazolidone, sulfonamides, enrofloxacin, doxycycline, piperacillin, florfenicol, gentamicin, and lincomycin. These results contribute to the understanding of pathological alterations in R. ventralis following A. veronii infection, offering valuable data to support the implementation of disease treatment.
Circular Fluid Heating—Transient Entropy Generation
Authors: Alic Fikret
Published: May 2024

A technical issue with fluid flow heating is the relatively small temperature increase as the fluid passes through the heating surface. The fluid does not spend enough time inside the heating source to significantly raise its temperature, despite the heating source itself experiencing a substantial increase. To address this challenge, the concept of the multiple circular heating of air was developed, forming the basis of this work. Two PTC heaters with longitudinal fins are located within a closed channel inside housing composed of a thermal insulation material. Air flows circularly from one finned surface to another. Analytical modeling and experimental testing were used in the analysis, with established restrictions and boundary conditions. An important outcome of the analysis was the methodology established for the optimization of the geometric and process parameters based on minimizing the transient thermal entropy. In conducting the analytical modeling, the temperature of the PTC heater was assumed to be constant at 150 °C and 200 °C. By removing the restrictions and adjusting the boundary conditions, the established methodology for the analysis and optimization of various thermally transient industrial processes can be applied more widely. The experimental determination of the transient thermal entropy was performed at a much higher air flow rate of 0.005 m3s−1 inside the closed channel. The minimum transient entropy also indicates the optimal time for the opening of the channel, allowing the heated air to exit. The novelty of this work lies in the controlled circular heating of the fluid and the establishment of the minimum transient thermal entropy as an optimization criterion.
Exploring Chitosan Lactate as a Multifunctional Additive: Enhancing Quality and Extending Shelf Life of Whole Wheat Bread
Authors: Singh Pratik , Yadav Vikas , Sahu Deblu , Kumar Krishan , Kim Doman , Yang Deng , Jayaraman Sivaraman , Jarzębski Maciej , Wieruszewski Marek , Pal Kunal
Published: May 2024

The shelf life of whole wheat bread (WWB) significantly impacts its freshness and overall quality. This research investigated the impact of chitosan lactate (CL) on various characteristics influencing the shelf life of WWB, including its physical, chemical, textural, antimicrobial, and sensory attributes. These characteristics were evaluated by conducting various experiments such as physical inspection, moisture, impedance, swelling, color, texture, FTIR, microbiological, and sensory analysis. CL with different concentrations was incorporated into WWB formulations: P0.0 (0.0% w/w CL, control), P0.5 (0.5% w/w CL), P1.0 (1.0% w/w CL), P2.0 (2.0% w/w CL), and P3.0 (3.0% w/w CL). The inclusion of CL promoted the Maillard reaction (MR) compared to P0.0. The promotion of MR resulted in the formation of a shinier crust, which increased as the CL content was increased. P0.5 comprised large-sized pores and exhibited increased loaf height. CL-containing WWB formulations showed an increased moisture content and decreased impedance values compared to the control. FTIR analysis of P0.5 demonstrated the enhanced interaction and bonding of water molecules. P0.5 demonstrated optimal textural, colorimetric, and antimicrobial properties compared to other formulations. The sensory attributes of WWBs remain unchanged despite CL addition. In conclusion, P0.5 exhibited optimal characteristics associated with better quality and prolonged shelf life.
Noether’s Theorem of Herglotz Type for Fractional Lagrange System with Nonholonomic Constraints
Authors: Deng Yuanyuan , Zhang Yi
Published: May 2024

This research aims to investigate the Noether symmetry and conserved quantity for the fractional Lagrange system with nonholonomic constraints, which are based on the Herglotz principle. Firstly, the fractional-order Herglotz principle is given, and the Herglotz-type fractional-order differential equations of motion for the fractional Lagrange system with nonholonomic constraints are derived. Secondly, by introducing infinitesimal generating functions of space and time, the Noether symmetry of the Herglotz type is defined, along with its criteria, and the conserved quantity of the Herglotz type is given. Finally, to demonstrate how to use this method, two examples are provided.
Synchronization of Fractional Delayed Memristive Neural Networks with Jump Mismatches via Event-Based Hybrid Impulsive Controller
Authors: Wang Huiyu , Liu Shutang , Wu Xiang , Sun Jie , Qiao Wei
Published: May 2024

This study investigates the asymptotic synchronization in fractional memristive neural networks of the Riemann–Liouville type, considering mixed time delays and jump mismatches. Addressing the challenges associated with discrepancies in the circuit switching speed and the accuracy of the memristor, this paper introduces an enhanced model that effectively navigates these complexities. We propose two novel event-based hybrid impulsive controllers, each characterized by unique triggering conditions. Utilizing advanced techniques in inequality and hybrid impulsive control, we establish the conditions necessary for achieving synchronization through innovative Lyapunov functions. Importantly, the developed controllers are theoretically optimized to minimize control costs, an essential consideration for their practical deployment. Finally, the effectiveness of our proposed approach is demonstrated through two illustrative simulation examples.
Exploring the Exact Solution of the Space-Fractional Stochastic Regularized Long Wave Equation: A Bifurcation Approach
Authors: Almutairi Bashayr , Al Nuwairan Muneerah , Aldhafeeri Anwar
Published: May 2024

This study explores the effects of using space-fractional derivatives and adding multiplicative noise, modeled by a Wiener process, on the solutions of the space-fractional stochastic regularized long wave equation. New fractional stochastic solutions are constructed, and the consistency of the obtained solutions is examined using the transition between phase plane orbits. Their bifurcation and dependence on initial conditions are investigated. Some of these solutions are shown graphically, illustrating both the individual and combined influences of fractional order and noise on selected solutions. These effects appear as alterations in the amplitude and width of the solutions, and as variations in their smoothness.
Unveiling the Complexity of HIV Transmission: Integrating Multi-Level Infections via Fractal-Fractional Analysis
Authors: Anjam Yasir Nadeem , Turki Alqahtani Rubayyi , Alharthi Nadiyah Hussain , Tabassum Saira
Published: May 2024

This article presents a non-linear deterministic mathematical model that captures the evolving dynamics of HIV disease spread, considering three levels of infection in a population. The model integrates fractal-fractional order derivatives using the Caputo operator and undergoes qualitative analysis to establish the existence and uniqueness of solutions via fixed-point theory. Ulam-Hyer stability is confirmed through nonlinear functional analysis, accounting for small perturbations. Numerical solutions are obtained using the fractional Adam-Bashforth iterative scheme and corroborated through MATLAB simulations. The results, plotted across various fractional orders and fractal dimensions, are compared with integer orders, revealing trends towards HIV disease-free equilibrium points for infective and recovered populations. Meanwhile, susceptible individuals decrease towards this equilibrium state, indicating stability in HIV exposure. The study emphasizes the critical role of controlling transmission rates to mitigate fatalities, curb HIV transmission, and enhance recovery rates. This proposed strategy offers a competitive advantage, enhancing comprehension of the model’s intricate dynamics.
Editorial for the Special Issue Titled “Design of Polymeric Hydrogels Biomaterials”
Authors: Serro Ana Paula , Vivero-Lopez Maria , Silva Diana C.
Published: May 2024

Hydrogels have attracted great interest in the biomedical applications field in recent years [...]
Functional Hydrogels Promote Vegetable Growth in Cadmium-Contaminated Soil
Authors: Huang Jin , Gotoh Takehiko , Nakai Satoshi , Ueda Akihiro
Published: May 2024

Over the years, the concentration of cadmium in soil has increased due to industrialization. Cadmium in the soil enters the human body through plant accumulation, seriously endangering human health. In the current study, two types of hydrogels were successfully synthesized using a free radical polymerization method: an ion-type hydrogel referred to as DMAPAA (N-(3-(Dimethyl amino) propyl) acrylamide)/DMAPAAQ (N,N-Dimethyl amino propyl acrylamide, methyl chloride quaternary) and a non-ion-type hydrogel known as DMAA (N,N-Dimethylacrylamide). In the experiment carried out in this study, the ion-type hydrogel DMAPAA/DMAPAAQ was introduced to cadmium-contaminated soil for vegetable cultivation. The study found that at cadmium levels of 0 and 2 mg/kg in soil, when exposed to a pH 2 solution, cadmium wasn’t detected in the filtrate using ICP. As the amount of cadmium increased to 500 mg/kg, hydrogel addition gradually reduced the filtrate cadmium concentration. Notably, the use of the 4% hydrogel resulted in 0 mg/L of cadmium. For the 0% hydrogel, vegetable cadmium absorption was determined to be 0.07 mg/g, contrasting with 0.03 mg/g for the 4% hydrogel. The DMAPAA/DMAPAAQ hydrogel significantly boosts vegetable growth by efficiently absorbing nitrate ions through ion exchange, releasing them for plant uptake. In contrast, the DMAA hydrogel, used as a control, does not enhance plant growth despite its water absorption properties. In summary, the composite hydrogel shows great potential for enhancing vegetable yield and immobilizing heavy metals in soil.
Bigel Matrix Loaded with Probiotic Bacteria and Prebiotic Dietary Fibers from Berry Pomace Suitable for the Development of Probiotic Butter Spread Product
Authors: Tamašauskaitė Laura , Minelgaitė Vidmantė , Šipailienė Aušra , Vinauskienė Rimantė , Eisinaitė Viktorija , Leskauskaitė Daiva
Published: May 2024

This study presents a novel approach to developing a probiotic butter spread product. We evaluated the prebiotic activity of soluble dietary fibers extracted from cranberry and sea buckthorn berry pomace with different probiotic strains (Limosilactobacillus reuteri, Lacticaseibacillus paracasei, and Lactiplantibacillus plantarum), uploaded selected compatible combination in the bigel matrix, and applied it in the probiotic butter spread formulation. Bigels and products were characterized by physical stability, rheological, textural properties, and viability of probiotics during storage at different conditions. The highest prebiotic activity score was observed in soluble cranberry (1.214 ± 0.029) and sea buckthorn (1.035 ± 0.009) fibers when cultivated with L. reuteri. The bigels loaded with probiotics and prebiotic fiber exhibited a significant increase in viscosity (higher consistency coefficient 40–45 Pa·sn) and better probiotic viability (>6 log CFU/g) during long-term storage at +4 °C temperature, surpassing the bigels loaded with probiotics alone. Bigels stored at a lower temperature (−18 °C) maintained high bacterial viability (above 8.5 log CFU/g). The butter spread enriched with the bigel matrix was softer (7.6–14.2 N), indicating improved spreadability. The butter spread product consistently met the required 6 log CFU/g for a functional probiotic food product until 60 days of storage at +4 °C temperature. The butter stored at −18 °C remained probiotic throughout the entire storage period, confirming the protective effect of the bigel matrix. The study’s results showed the potential of the bigel to co-encapsulate, protect, and deliver probiotics during prolonged storage under different conditions.
The Landscape of Presence/Absence Variations during the Improvement of Rice
Authors: Zhou Xia , Qiang Chenggen , Chen Lei , Qing Dongjin , Huang Juan , Li Jilong , Pan Yinghua
Published: May 2024

Rice is one of the most important staple crops in the world; therefore, the improvement of rice holds great significance for enhancing agricultural production and addressing food security challenges. Although there have been numerous studies on the role of single-nucleotide polymorphisms (SNPs) in rice improvement with the development of next-generation sequencing technologies, research on the role of presence/absence variations (PAVs) in the improvement of rice is limited. In particular, there is a scarcity of studies exploring the traits and genes that may be affected by PAVs in rice. Here, we extracted PAVs utilizing resequencing data from 148 improved rice varieties distributed in Asia. We detected a total of 33,220 PAVs and found that the number of variations decreased gradually as the length of the PAVs increased. The number of PAVs was the highest on chromosome 1. Furthermore, we identified a 6 Mb hotspot region on chromosome 11 containing 1091 PAVs in which there were 29 genes related to defense responses. By conducting a genome-wide association study (GWAS) using PAV variation data and phenotypic data for five traits (flowering time, plant height, flag leaf length, flag leaf width, and panicle number) across all materials, we identified 186 significantly associated PAVs involving 20 cloned genes. A haplotype analysis and expression analysis of candidate genes revealed that important genes might be affected by PAVs, such as the flowering time gene OsSFL1 and the flag leaf width gene NAL1. Our work investigated the pattern in PAVs and explored important PAV key functional genes associated with agronomic traits. Consequently, these results provide potential and exploitable genetic resources for rice breeding.
Community-Based Health Education Led by Women’s Groups Significantly Improved Maternal Health Service Utilization in Southern Ethiopia: A Cluster Randomized Controlled Trial
Authors: Yoseph Amanuel , Teklesilasie Wondwosen , Guillen-Grima Francisco , Astatkie Ayalew
Published: May 2024

Objective: This study aimed to evaluate the effect of health education intervention (HEI) on maternal health service utilization (MHSU) in southern Ethiopia. Methods: From 10 January to 1 August 2023, a community-based, two-arm, parallel-group cluster randomized controlled trial (cRCT) was conducted among pregnant mothers in the Northern Zone of Sidama National Regional State, Ethiopia. We utilized multilevel mixed-effects modified Poisson regression with robust variance to control for the effects of clustering and potential confounders. The level of significance was adjusted for multiple comparisons. Results: The overall utilization of at least one antenatal care (ANC) visit was 90.2% in the treatment group and 59.5% in the comparator group (χ2 = 89.22, p < 0.001). Health facility delivery (HFD) utilization was considerably different between the treatment group (74.3%) and the comparator group (50.8%) (χ2 = 70.50, p < 0.001). HEI significantly increased ANC utilization (adjusted risk ratio [ARR]: 1.32; 99% CI: 1.12–1.56) and HFD utilization (ARR: 1.24; 99% CI: 1.06–1.46). The utilization of at least one postnatal care (PNC) service was 65.4% in the treatment group and 52.1% in the comparator group (χ2 = 19.51, p = 0.01). However, after controlling for the effects of confounders and clustering, the impact of HEI on PNC utilization was insignificant between the two groups (ARR: 1.15; 99% CI: 0.89–1.48). Conclusion: A community-based HEI significantly increased ANC and HFD utilization but did not increase PNC utilization. Expanding the HEI with certain modifications will have a superior effect on improving MHSU. Trial registration number: NCT05865873.
Assessment of Paracetamol Usage Practices and Perceptions among Caregivers for Children Post-COVID-19 in Saudi Arabia: A Cross-Sectional Analysis
Authors: Alqahtani Saad S. , Banji David , Banji Otilia J. F.
Published: May 2024

Caregivers often use paracetamol in the management of pediatric illnesses without a clear rationale. This study evaluated the perception and practices of caregivers regarding the use of paracetamol in children in Southwestern Saudi Arabia. This study involved a cross-sectional design involving 373 caregivers of children under twelve. The questionnaire elucidated the reasons, usage frequency, and safe usage practices. Data were analyzed using SPSS, applying Chi-square tests and logistic regression. Most caregivers were in the age range of 31–40 years, and with intermediate education. Paracetamol was mainly used for fever, generalized pain and, diarrhea, with fewer opting for other self-care measures. Caregivers with primary or less education were more likely to perceive paracetamol as safe (AOR = 2.98 (1.3–6.73), p = 0.009) and less inclined to check warning labels (AOR: 0.11 (0.05–0.25), p < 0.001) and expiry dates (AOR: 0.063 (0.027–0.14), p < 0.001). The caregiver’s education level significantly influenced the determination of treatment duration (χ2 = 21.58 (4), p < 0.001), dosage (χ2 = 30.70 (4), p < 0.001), and frequency of administration (χ2 = 17.77 (4), p = 0.001). In conclusion, inadequate health literacy can result in a lack of attention towards crucial safety information about pediatric paracetamol use. Hence, counselling initiatives should be undertaken to ensure the safe and effective use of paracetamol in children.
Inequalities in Out-of-Pocket Health Expenditure Measured Using Financing Incidence Analysis (FIA): A Systematic Review
Authors: Shaltynov Askhat , Jamedinova Ulzhan , Semenova Yulia , Abenova Madina , Myssayev Ayan
Published: May 2024

Government efforts and reforms in health financing systems in various countries are aimed at achieving universal health coverage. Household spending on healthcare plays a very important role in achieving this goal. The aim of this systematic review was to assess out-of-pocket health expenditure inequalities measured by the FIA across different territories, in the context of achieving UHC by 2030. A comprehensive systematic search was conducted in the PubMed, Scopus, and Web of Science databases to identify original quantitative and mixed-method studies published in the English language between 2016 and 2022. A total of 336 articles were initially identified, and after the screening process, 15 articles were included in the systematic review, following the removal of duplicates and articles not meeting the inclusion criteria. Despite the overall regressivity, insurance systems have generally improved population coverage and reduced inequality in out-of-pocket health expenditures among the employed population, but regional studies highlight the importance of examining the situation at a micro level. The results of the study provide further evidence supporting the notion that healthcare financing systems relying less on public funding and direct tax financing and more on private payments are associated with a higher prevalence of catastrophic health expenditures and demonstrate a more regressive pattern in terms of healthcare financing, highlighting the need for policy interventions to address these inequities. Governments face significant challenges in achieving universal health coverage due to inequalities experienced by financially vulnerable populations, including high out-of-pocket payments for pharmaceutical goods, informal charges, and regional disparities in healthcare financing administration.
Practical Guidelines for Farm Waste Utilization in Sustainable Kale Production
Authors: Thepsilvisut Ornprapa , Srikan Nuengruethai , Chutimanukul Preuk , Athinuwat Dusit , Chuaboon Wilawan , Marubodee Rusama , Ehara Hiroshi
Published: May 2024

Natural amendments from agricultural waste to improve soil physicochemical properties continuously attract research interest in promoting eco-friendly plant production. The present study evaluated the proper use of sawdust, biochar, and compost made from farm waste for kale production from seedling propagation to field conditions. From the seedling propagation process, the results demonstrate that the most suitable growing medium for kale seedings was 0.5:1:1 v/v of sawdust + biochar + compost, which gave the fastest mean germination times (2.71 days) and the highest seed germination percentage (78.33%). In addition to investigating the selected growing media as the soil amendments at five different rates (0, 6.25, 12.50, 18.75, 25.00, and 31.25 t ha−1), the result reveals that the fresh weight of marketable leaves was significantly highest under the 31.25 t ha−1 treatment. The application rate that yielded the highest gross profit margins was eight times higher than the control. Moreover, in some harvesting periods, the kale leaf yields under the treatment of 31.25 t ha−1 showed higher total chlorophyll and carotenoid contents.
Recent Advances in Understanding and Controlling Fusarium Diseases of Alliums
Authors: Sharma Suman , Mandal Subhankar , Cramer Christopher S.
Published: May 2024

Allium species are known for their culinary, medicinal, and ornamental purposes. Fusarium basal rot is one of the most damaging soilborne fungal diseases of Allium species and poses a significant threat to yield, quality, and storage life worldwide. Various species of Fusarium have been identified as causal agents for Fusarium basal rot, depending on the Allium species involved. Diverse disease management practices have been implemented to mitigate the impact of Fusarium basal rot. This review article provides a comprehensive overview of the recent progress in detecting different species of Fusarium involved in Fusarium basal rot and strategies to control them in affected Allium species involving chemical, biological, and cultural methods. It covers the latest advancements in host plant resistance research from traditional breeding to modern molecular techniques and studying secondary metabolites involved in defense mechanisms against Fusarium basal rot.
Genetic Mapping for Leaf Shape and Leaf Size in Non-Heading Chinese Cabbage by a RIL Population
Authors: Zhao Tianzi , Bai Aimei , Wang Xinya , Zhang Feixue , Yang Miaomiao , Wang Yuhui , Liu Tongkun , Hou Xilin , Li Ying
Published: May 2024

Leaves are the predominant photosynthetic and edible organs in non-heading Chinese cabbage (Brassica campestris ssp. chinensis, NHCC), contributing significantly to yield, appearance, and desirability to consumers. However, the genetic basis of leaf shape and size in non-heading Chinese cabbage remains unclear. In this study, we developed a RIL population using ‘Maertou’, with slender leaves and narrow petioles, and ‘Suzhouqing’, with oval leaves and wide petioles, to construct a genetic linkage map and detect QTLs. To obtain stable and reliable QTLs, the 11 leaf-related traits, including the leaf length, leaf width, and fresh weight of the lamina and petiole and the thickness of petiole was observed on two locations—while the leaf shape, petiole shape, index of lamina/petiole length, and index of petiole fresh weight were calculated based on 7 leaf-related traits. QTL mapping illustrated that a total of 27 QTLs for leaf-related traits were preliminarily detected. The candidate genes were annotated and several genes involved in leaf development and leaf shape appeared in the overlapping regions of multiple loci, such as KRP2, GRF4, ARGOS, and SAUR9. This study lays the foundation for further exploration of the genetic mechanisms and development of effective molecular markers for leaf shape and size in NHCC.
Insights into Medieval Grape Cultivation in Al-Andalus: Morphometric, Domestication, and Multivariate Analysis of Vitis vinifera Seed Types
Authors: Valera Javier , Rivera Diego , Matilla-Séiquer Gonzalo , Rivera-Obón Diego José , Ocete Carlos-Alvar , Ocete Rafael , Navarro Julio , Jiménez Pedro , González Rafael , Ramírez Juan Antonio , Moreno José María , Martínez José Javier , Obón Concepción
Published: May 2024

Understanding the origins and evolution of modern grapevine varieties in the Iberian Peninsula and western Europe necessitates an examination of the proportions of Vitis vinifera cultivars, their relationships with wild grapevine populations, and the utilization of seedless cultivars in al-Andalus. Employing morphometric studies, domestication indices, multivariate analysis, and Bayesian hypothesis testing, this study investigates several distinct seed types identified in materials from Roman and medieval deposits. These seeds exhibit a spectrum from highly domesticated to purely wild. Our findings reveal the predominance of Proles Occidentalis Negrul, and the presence of feral-like grapevines associated with Proles Euphratica. Additionally, we observe the continuous presence of wild grapevines related to Vitis sylvestris CC Gmelin throughout the studied period. Seeds exhibiting intermediate characteristics are documented, alongside the identification of “stenosperms”, suggesting anomalies in seed formation. Notably, the presence of Vitis vinifera raisins “stenospermocarpics” of the sultana type is suggested, potentially elucidating the absence of table grapes and raisins of the Proles Orientalis Negrul in the archaeological record, despite frequent mentions by medieval agronomy writers from al-Andalus.
Integration of GIS and Water-Quality Index for Preliminary Assessment of Groundwater Suitability for Human Consumption and Irrigation in Semi-Arid Region
Authors: Benmarce Kaddour , Zighmi Karim , Hadji Riheb , Hamed Younes , Gentilucci Matteo , Barbieri Maurizio , Pambianchi Gilberto
Published: May 2024

The Setifian high-plains region, Northeast of Algeria, grapples with challenges in water resource management. As the water demand intensifies across a diverse range of sectors, assessing groundwater quality becomes indispensable. This article responds to the critical need for a thorough assessment of groundwater quality in the Wadi Boussellam sub-watershed. Employing a GIS-based method, we evaluate groundwater geochemistry by estimating the Water Quality Index (WQI), offering a comprehensive overview of water consumption. The analysis of groundwater samples reveals distinct facies, including calcic bicarbonate, calcic chloride, calcic sulfate, and magnesium sulfate, contributing to an enhanced understanding of the hydrochemical composition in the Setif region. Hydrochemical indices, specifically the WQI, Sodium Adsorption Ratio (SAR), and Na% are applied to assess groundwater suitability for various applications. The results indicate that most crops are generally suitable for irrigation, though they advise exercising caution with regard to human consumption. This study underscores the significance of regular monitoring to avert groundwater contamination and ensure sustainable use in the Setif region, providing insights that emphasize the ongoing necessity for efforts in water resource management and the preservation of this vital resource’s quality.
Sovereign Green Bond Market: Drivers of Yields and Liquidity
Authors: Tomczak Kamila
Published: May 2024

The aim of this study is to analyse and assess the yields and liquidity of sovereign green bonds in selected countries and to compare the yields between sovereign green bonds and conventional bonds. Sovereign green bonds are issued by governments to finance environmental and social projects and represent a relatively new and growing asset class. This study seeks to analyse the financial performance of sovereign green bonds by examining yields and liquidity metrics, such as bid–ask spreads. The findings of this research suggest that the yield to maturity (YTM) of sovereign green bonds is influenced by conventional bond return, while conventional sovereign bonds are affected by the financial market return. Furthermore, the results confirm that the liquidity of sovereign green bonds can be explained by bond maturity.
Functional Characteristics of Antioxidant Long-Life Ultra-Fine Bubble Hydrogen Water
Authors: Kamimura Chikashi , Ohba Riichiro , Yamaguchi Masaru , Hosoda Masato , Kashiwakura Ikuo
Published: May 2024

Free radicals, including reactive oxygen species resulting from oxidative stress, are one of the major causes of biological disorders and are known to be closely related to the onset of lifestyle-related diseases such as aging, atherosclerosis, and diabetes, and their complications. Hydroxyl radicals, the most reactive and cytotoxic of reactive oxygen species, are selectively reduced by hydrogen. We have developed a method to produce more stable hydrogen water by dispersing hydrogen in water using ultra-fine bubbles (UFBs) with a bubble diameter of less than 1 μm. The present study reported on the functional characteristics of antioxidant long-life UFB hydrogen water. UFB hydrogen water with excellent storage stability is expected to have a variety of potential medical applications, including radiation damage reduction.
Temperature-Dependent Residual Stresses and Thermal Expansion Coefficient of VO2 Thin Films
Authors: Tien Chuen-Lin , Chiang Chun-Yu , Wang Ching-Chiun , Lin Shih-Chin
Published: May 2024

This study aims to investigate the thermomechanical properties of vanadium dioxide (VO2) thin films. A VO2 thin film was simultaneously deposited on B270 and H-K9L glass substrates by electron-beam evaporation with ion-assisted deposition. Based on optical interferometric methods, the thermal–mechanical behavior of and thermal stresses in VO2 films can be determined. An improved Twyman–Green interferometer was used to measure the temperature-dependent residual stress variations of VO2 thin films at different temperatures. This study found that the substrate has a great impact on thermal stress, which is mainly caused by the mismatch in the coefficient of thermal expansion (CTE) of the film and the substrate. By using the dual-substrate method, thermal stresses in VO2 thin films from room temperature to 120 °C can be evaluated. The thermal expansion coefficient is 3.21 × 10−5 °C−1, and the biaxial modulus is 517 GPa.
Genetics of Hypertension: From Monogenic Analysis to GETomics
Authors: Zappa Martina , Golino Michele , Verdecchia Paolo , Angeli Fabio
Published: May 2024

Arterial hypertension is the most frequent cardiovascular risk factor all over the world, and it is one of the leading drivers of the risk of cardiovascular events and death. It is a complex trait influenced by heritable and environmental factors. To date, the World Health Organization estimates that 1.28 billion adults aged 30–79 years worldwide have arterial hypertension (defined by European guidelines as office systolic blood pressure ≥ 140 mmHg or office diastolic blood pressure ≥ 90 mmHg), and 7.1 million die from this disease. The molecular genetic basis of primary arterial hypertension is the subject of intense research and has recently yielded remarkable progress. In this review, we will discuss the genetics of arterial hypertension. Recent studies have identified over 900 independent loci associated with blood pressure regulation across the genome. Comprehending these mechanisms not only could shed light on the pathogenesis of the disease but also hold the potential for assessing the risk of developing arterial hypertension in the future. In addition, these findings may pave the way for novel drug development and personalized therapeutic strategies.
Untangling the Complex Associations between Socioeconomic and Demographic Characteristics and Prenatal Detection and Outcomes in Congenital Heart Disease
Authors: Klein Jennifer H. , Donofrio Mary T.
Published: May 2024

Recent literature has established a strong foundation examining the associations between socioeconomic/demographic characteristics and outcomes for congenital heart disease. These associations are found beginning in fetal life and influence rates of prenatal detection, access to timely and appropriate delivery room and neonatal interventions, and surgical and other early childhood outcomes. This review takes a broad look at the existing literature and identifies gaps in the current body of research, particularly as it pertains to disparities in the prenatal detection of congenital heart disease within the United States. It also proposes further research and interventions to address these health disparities.
Impact of Surgical Timing on Functional Outcomes after Anterior Cruciate Ligament Reconstruction
Authors: Kawashima Tatsuhiro , Mutsuzaki Hirotaka , Watanabe Arata , Ikeda Kotaro , Yamanashi Yuki , Kinugasa Tomonori
Published: May 2024

Objectives: Although acute anterior cruciate ligament reconstruction (ACLR) is often avoided because of postoperative joint stiffness, delayed ACLR can lead to a longer recovery time and can have a negative impact on physical function due to detraining. This study aimed to determine the effects of acute ACLR on postoperative outcomes, including muscle strength, performance, and return to sports. Methods: A total of 110 patients who underwent anatomical ACLR using hamstring autografts were included in this study and were divided into three groups: acute (ACLR performed within 2 weeks after ACL injury), 2–6 weeks (ACLR performed between 2 and 6 weeks after injury), and 6–12 weeks (ACLR performed between 6 and 12 weeks after injury). Several parameters were evaluated, including range of motion, knee joint stability, isokinetic knee strength, performance, and return to sports. Results: No significant differences were found in the range of motion or knee joint stability between the groups. The acute group exhibited significantly greater quadriceps strength at 3 months postoperatively than the other groups (p < 0.05). The single-leg hop test showed that 66.7%, 38.7%, and 33.3% of the patients in the acute, 2–6 weeks, and 6–12 weeks groups, respectively, recovered to an LSI of 90% or greater (p = 0.09, Cramer’s V = 0.27). All patients in the acute group were able to return to sports (p = 0.14; Cramer’s V = 0.28). Conclusions: Acute ACLR is advantageous for the early recovery of strength and performance without adverse events. Acute ACLR may shorten the time spent away from sports activities.