bluuebunny/crossref_metadata_2025 huggingface dataset:
New Operative Protocol for Immediate Post-Extraction Implant in Lower-First-Molar Region with Rex-Blade Implants: A Case Series with 18 Months of Follow-Up
Authors: Bambini Fabrizio , Memè Lucia , Rossi Roberto , Grassi Andrea , Grego Serena , Mummolo Stefano
Published: September 2023

In this manuscript, the authors propose a new technique for inserting implants immediately into the sockets corresponding to the lower first molars and, in any case, in the sockets in which the alveolar septum is still present. Immediate post-extraction implants are a widely discussed topic in the literature. Most authors currently consider the insertion of implants immediately after extraction less useful in terms of the procedure’s questionable benefits in maintaining the height of the alveolar bone and more useful in terms of lessening patients’ discomfort. Due to the anatomy of the post-extraction socket and its traditionally cylindrical geometry, this procedure is not always possible.: Next-generation REX-type blade implants were used via their insertion into the septum accompanied by a cortical lamina for periosteal inhibition without filling any of the alveoli.: In the 20 patients treated, the REX implant proved to be stable and surrounded by newly formed bone at the 18-month follow-up. This simple, easily employable technique allows an implant to be inserted immediately after extraction and in the same surgical session, with good patient compliance and good preservation of the alveolus due to the facilitation of periosteal inhibition. The excellent clinical results obtained with the use of a blade implant in the posterior sectors suggest that it is possible to reduce surgical sessions even in conditions of post-extraction sockets whose septum alone can ensure the primary stability essential for osseointegration. The use of a larger number of patients will also provide us with significant statistical results in support of this preliminary clinical work. New clinical studies are needed to understand the true potential of this method for application in daily clinical practice.
The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis
Authors: Gao Xiaoxiao , Gao Han , Shao Wei , Wang Jiaqi , Li Mingqing , Liu Songping
Published: September 2023

Endometriosis (EMs) is a common disease among women whose pathogenesis is still unclear, although there are various hypotheses. Recent studies have considered macrophages the key part of the immune system in developing EMs, inducing inflammation, the growth and invasion of the ectopic endometrium, and angiogenesis. Extracellular vesicles (EVs) as novel intercellular vesicle traffic, can be secreted by many kinds of cells, including macrophages. By carrying long non-coding RNA (lncRNA), microRNA (miRNA), or other molecules, EVs can regulate the biological functions of macrophages in an autocrine and paracrine manner, including ectopic lesion growth, immune dysfunction, angiogenesis, and can further accelerate the progression of EMs. In this review, the interactions between macrophages and EVs for the pathogenesis of EMs are summarized. Notably, the regulatory pathways and molecular mechanisms of EVs secreted by macrophages during EMs are reviewed.
In Vitro Expression Analysis Reveals HML6-c14 to Be an Attractive Research Target
Authors: Oda Takaya
Published: September 2023

HML6-c14, a long terminal repeat (LTR)-type retrotransposon identified by expressed sequence tag (EST) database screening, was found to undergo RNA processing resembling that of placental tissue by in vitro expression analysis. Previous in situ hybridization studies using normal placental tissue showed that the transcript remained in the nucleus. However, among the transcripts forcedly expressed in cultured cells, the transcript that retained the 3.3 kb intron was observed in the nucleus, and a part of the spliced transcript was observed outside the nucleus. To verify whether this cytoplasmic transcript could be translated, we examined the coding potential of the open reading frame (ORF), consisting of 109 codons on the spliced transcript, along with two other putative ORFs detected in the intronic region. As a result, none of the ORF-derived products could be detected by Western blotting as fusion proteins tagged with the FLAG epitope, suggesting that HML6-c14 belongs to a group of long non-coding RNA (lncRNA) genes. Promoter analysis of the upstream 6.4 kb genomic region also suggested that the 5′-LTR itself potentially retains high promoter activity. Despite losing the ability to produce functional proteins, HML6-c14 continues to retain its transcriptional ability while converting to an lncRNA gene, which is an interesting subject for future research.
Parent–Adolescent Conflict: Adolescents’ Coping Strategies and Preferred Parenting Styles during the Social Movements in Hong Kong, 2019
Authors: Low Andrew Yiu Tsang
Published: September 2023

This research investigated parent–adolescent conflict, conflict resolution strategies and perceived parenting styles by adolescents during the social movements in Hong Kong in 2019, a period characterized by considerable social unrest in which many young people participated in demonstrations and protests. The study drew on responses from 866 adolescents aged between 11 and 16 who completed a questionnaire that included a conflict issue checklist and elicited respondents’ conflict resolution strategies as well as perceived parenting styles. Correlation analysis was performed to identify the correlation of parent–adolescent conflicts with differences in political stances with their parents and other demographic data. Regression analysis was performed to identify the correlation of perceived parenting styles and conflict resolution strategies adopted by adolescents. Results indicated that early adolescents have a higher intensity of conflicts with their parents than late adolescents in this period. Respondents had more intense conflicts with their parents over political differences and ways of expressing their political views than other issues. Those respondents in conflict or ineffective arguing strategies perceived their parents as more authoritarian than those who adopt positive conflict resolution strategies. However, when asked about their ideal ways of resolving conflicts, adolescents preferred problem-solving rather than conflict strategies.
A Systematic Investigation of Lead-Free Electroless Ni-B-W Coating Properties Using Taguchi’s Methodology
Authors: Agrawal Rohit , Prakash Om , Brar Lakhbir Singh , Mukhopadhyay Arkadeb
Published: September 2023

Electroless Ni-B (ENB) coatings have industrial importance due to their excellent mechanical properties. The inclusion of W (ENB-W) to the coatings further enhances their mechanical properties and thermal stability. Nevertheless, the ENB or ENB-W coatings are deposited from a heavy metal-stabilized bath, and the very commonly used stabilizer is lead nitrate. The present work is an attempt to obtain an ENB-W coating with enhanced mechanical properties and elimination of the stabilizer from the bath. To achieve this, the coating bath temperature, the heat treatment temperature and the heat treatment duration were varied systematically following a strategy adopted from Taguchi’s experimental design. The mechanical properties targeted include surface microhardness and scratch hardness. Multi-objective optimization was performed using gray relational methodology. The predicted bath temperature was 85 °C, while the predicted heat treatment temperature was 450 °C and there was 3 h of heat treatment time. The optimized lead-free ENB-W coatings had a microhardness of 1096.2 HV100 and scratch hardness of 13.86 GPa. In fact, single-objective optimization for surface microhardness and scratch hardness by Taguchi’s methodology also predicted the same optimal parametric condition for both scratch hardness and surface microhardness. This was comparable to that of a lead-stabilized ENB-W coating and higher than the as-plated stabilizer free ENB-W coatings. The coating failure of the optimized ENB-W alloy was tested using a progressive scratch test, which showed that there was no chevron or transverse cracks within the load range considered. Analysis of corrosion resistance revealed that the corrosion potential of the optimized coatings was −407 mV, and this was comparable to that of a lead-based ENB-W coating.
Investigation of Ion Release and Antibacterial Properties of TiN-Cu-Nanocoated Nitinol Archwires
Authors: Ilić Bojana , Petrović Božana , Marinković Jelena , Miletić Vukajlović Jadranka , Stevanović Momir , Potočnik Jelena , Jokanović Vukoman
Published: September 2023

Background: The use of nitinol (NiTi) archwires in orthodontic treatment has increased significantly due to unique mechanical properties. The greatest obstacle for safe orthodontic treatment is chemically or microbiologically induced corrosion, resulting in nickel (Ni) release. The aim of this investigation was to enhance corrosion resistance and introduce antibacterial properties to NiTi archwires by coating them with copper (Cu) doper titanium nitride (TiN-Cu). Methods: NiTi archwires were coated with TiN-Cu using cathodic arc evaporation (CAE) and direct current magnetron sputtering (DC-MS). The morphology of the sample was analyzed via field emission scanning electron microscopy (FESEM) and chemical composition was assessed using energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR). Inductively coupled plasma optical emission spectrometry (ICP-OES) was used to estimate the ion release. The biocompatibility of samples was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Antibacterial activity was tested against Streptococcus mutans and Streptococcus mitis. Results: Physicochemical characterization revealed well-designed coatings with the presence of TiN phase with incorporated Cu. TiN-Cu-nanocoated archwires showed a statistically lower Ni release (p < 0.05). Relative cell viability was the highest in 28-day eluates of TiN-Cu-nanocoated archwires (p < 0.05). The most remarkable decrease in Streptococcus mitis concentrations was observed in the case of TiN-Cu-coated archwires (p < 0.05). Conclusion: Taking into account biocompatibility and antibacterial tests, TiN-Cu-nanocoated archwires may be considered as a good candidate for further clinical investigations.
Magnetic Zeolite: Synthesis and Copper Adsorption Followed by Magnetic Separation from Treated Water
Authors: Buzukashvili Sofi , Hu Weiqing , Sommerville Roberto , Brooks Oliver , Kökkılıç Ozan , Rowson Neil A. , Ouzilleau Philippe , Waters Kristian E.
Published: September 2023

Zeolites are widely used in diverse applications, including the removal of heavy metals from wastewater. However, separating fine-sized zeolite particles from treated water is often a challenge. In this work, a novel method utilizing a colloidal polyvinyl alcohol (PVA) solution to bind iron oxide nanoparticles to a Linde Type A (LTA) zeolite was used to synthesize magnetic zeolite. Different zeolite–iron oxide nanoparticle loadings (10:1, 10:0.5, and 10:0.1) were used in batch adsorption experiments to investigate adsorption capacities and kinetics for Cu removal from an aqueous solution. The results showed that the magnetic zeolite maintained much of its adsorbent properties while facilitating a simplified process design. Thus, the adsorption capacity of pure LTA zeolite was found to be 262 mg/g for magnetic zeolite, with a 10:1 ratio—151 mg/g; 10:0.5—154 mg/g; and 10:0.1—170 mg/g. Magnetic separation was subsequently employed to remove the magnetic zeolite from the treated solution.
MRI-Based Radiomics Analysis of Levator Ani Muscle for Predicting Urine Incontinence after Robot-Assisted Radical Prostatectomy
Authors: Shahait Mohammed , Usamentiaga Ruben , Tong Yubing , Sandberg Alex , Lee David I. , Udupa Jayaram K. , Torigian Drew A.
Published: September 2023

Background: The exact role of the levator ani (LA) muscle in male continence remains unclear, and so this study aims to shed light on the topic by characterizing MRI-derived radiomic features of LA muscle and their association with postoperative incontinence in men undergoing prostatectomy. Method: In this retrospective study, 140 patients who underwent robot-assisted radical prostatectomy (RARP) for prostate cancer using preoperative MRI were identified. A biomarker discovery approach based on the optimal biomarker (OBM) method was used to extract features from MRI images, including morphological, intensity-based, and texture-based features of the LA muscle, along with clinical variables. Mathematical models were created using subsets of features and were evaluated based on their ability to predict continence outcomes. Results: Univariate analysis showed that the best discriminators between continent and incontinent patients were patients age and features related to LA muscle texture. The proposed feature selection approach found that the best classifier used six features: age, LA muscle texture properties, and the ratio between LA size descriptors. This configuration produced a classification accuracy of 0.84 with a sensitivity of 0.90, specificity of 0.75, and an area under the ROC curve of 0.89. Conclusion: This study found that certain patient factors, such as increased age and specific texture properties of the LA muscle, can increase the odds of incontinence after RARP. The results showed that the proposed approach was highly effective and could distinguish and predict continents from incontinent patients with high accuracy.
Automatic Heart Rate Detection during Sleep Using Tracheal Audio Recordings from Wireless Acoustic Sensor
Authors: Tomaszewska Julia Zofia , Młyńczak Marcel , Georgakis Apostolos , Chousidis Christos , Ładogórska Magdalena , Kukwa Wojciech
Published: September 2023

Background: Heart rate is an essential diagnostic parameter indicating a patient’s condition. The assessment of heart rate is also a crucial parameter in the diagnostics of various sleep disorders, including sleep apnoea, as well as sleep/wake pattern analysis. It is usually measured using an electrocardiograph (ECG)—a device monitoring the electrical activity of the heart using several electrodes attached to a patient’s upper body—or photoplethysmography (PPG). Methods: The following paper investigates an alternative method for heart rate detection and monitoring that operates on tracheal audio recordings. Datasets for this research were obtained from six participants along with ECG Holter (for validation), as well as from fifty participants undergoing a full night polysomnography testing, during which both heart rate measurements and audio recordings were acquired. Results: The presented method implements a digital filtering and peak detection algorithm applied to audio recordings obtained with a wireless sensor using a contact microphone attached in the suprasternal notch. The system was validated using ECG Holter data, achieving over 92% accuracy. Furthermore, the proposed algorithm was evaluated against whole-night polysomnography-derived HR using Bland-Altman’s plots and Pearson’s Correlation Coefficient, reaching the average of 0.82 (0.93 maximum) with 0 BPM error tolerance and 0.89 (0.97 maximum) at ±3 BPM. Conclusions: The results prove that the proposed system serves the purpose of a precise heart rate monitoring tool that can conveniently assess HR during sleep as a part of a home-based sleep disorder diagnostics process.
Application of Machine Learning Algorithms for Prognostic Assessment in Rotator Cuff Pathologies: A Clinical Data-Based Approach
Authors: Longo Umile Giuseppe , Di Naro Calogero , Campisi Simona , Casciaro Carlo , Bandini Benedetta , Pareek Ayoosh , Bruschetta Roberta , Pioggia Giovanni , Cerasa Antonio , Tartarisco Gennaro
Published: September 2023

Aim: The overall aim of this proposal is to ameliorate the care of rotator cuff (RC) tear patients by applying an innovative machine learning approach for outcome prediction after arthroscopic repair. Materials and Methods: We applied state-of-the-art machine learning algorithms to evaluate the best predictors of the outcome, and 100 RC patients were evaluated at baseline (T0), after 1 month (T1), 3 months (T2), 6 months (T3), and 1 year (T4) from surgical intervention. The outcome measure was the Costant–Murley Shoulder Score, whereas age, sex, BMI, the 36-Item Short-Form Survey, the Simple Shoulder Test, the Hospital Anxiety and Depression Scale, the American Shoulder and Elbow Surgeons Score, the Oxford Shoulder Score, and the Shoulder Pain and Disability Index were considered as predictive factors. Support vector machine (SVM), k-nearest neighbors (k-NN), naïve Bayes (NB), and random forest (RF) algorithms were employed. Results: Across all sessions, the classifiers demonstrated suboptimal performance when using both the complete and shrunken sets of features. Specifically, the logistic regression (LR) classifier achieved a mean accuracy of 46.5% ± 6%, while the random forest (RF) classifier achieved 51.25% ± 4%. For the shrunken set of features, LR obtained a mean accuracy of 48.5% ± 6%, and RF achieved 45.5% ± 4.5%. No statistical differences were found when comparing the performance metrics of ML algorithms. Conclusions: This study underlines the importance of extending the application of AI methods to new predictors, such as neuroimaging and kinematic data, in order to better record significant shifts in RC patients’ prognosis. Limitations: The data quality within the cohort could represent a limitation, since certain variables, such as smoking, diabetes, and work injury, are known to have an impact on the outcome.
Exercise-Induced Arrhythmia or Munchausen Syndrome in a Marathon Runner?
Authors: Gajda Robert , Drygas Wojciech , Gajda Jacek , Kiper Pawel , Knechtle Beat , Kwaśniewska Magdalena , Sterliński Maciej , Biernacka Elżbieta Katarzyna
Published: September 2023

A 36-year-old professional marathon runner reported sudden irregular palpitations occurring during competitions, with heart rates (HR) up to 230 bpm recorded on a sports HR monitor (HRM) over 4 years. These episodes subsided upon the cessation of exercise. Electrocardiograms, echocardiography, and cardiac magnetic resonance imaging results were borderline for athlete’s heart. Because an electrophysiology study and standard exercise tests provoked no arrhythmia, doctors suspected Munchausen syndrome. Ultimately, an exercise test that simulated the physical effort of a competition provoked tachyarrhythmia consistent with the HRM readings. This case demonstrates the diagnostic difficulties related to exercise-induced arrhythmia and the diagnostic usefulness of sports HRMs.
Medical Image Despeckling Using the Invertible Sparse Fuzzy Wavelet Transform with Nature-Inspired Minibatch Water Wave Swarm Optimization
Authors: Amarnath Ahila , Manoharan Poongodi , Natarajan Buvaneswari , Alroobaea Roobaea , Alsafyani Majed , Baqasah Abdullah M. , Keshta Ismail , Raahemifar Kaamran
Published: September 2023

Speckle noise is a pervasive problem in medical imaging, and conventional methods for despeckling often lead to loss of edge information due to smoothing. To address this issue, we propose a novel approach that combines a nature-inspired minibatch water wave swarm optimization (NIMWVSO) framework with an invertible sparse fuzzy wavelet transform (ISFWT) in the frequency domain. The ISFWT learns a non-linear redundant transform with a perfect reconstruction property that effectively removes noise while preserving structural and edge information in medical images. The resulting threshold is then used by the NIMWVSO to further reduce multiplicative speckle noise. Our approach was evaluated using the MSTAR dataset, and objective functions were based on two contrasting reference metrics, namely the peak signal-to-noise ratio (PSNR) and the mean structural similarity index metric (MSSIM). Our results show that the suggested approach outperforms modern filters and has significant generalization ability to unknown noise levels, while also being highly interpretable. By providing a new framework for despeckling medical images, our work has the potential to improve the accuracy and reliability of medical imaging diagnosis and treatment planning.
A Novel Multi-Robot Task Assignment Scheme Based on a Multi-Angle K-Means Clustering Algorithm and a Two-Stage Load-Balancing Strategy
Authors: You Jiangwei , Jia Jianfang , Pang Xiaoqiong , Wen Jie , Shi Yuanhao , Zeng Jianchao
Published: September 2023

A practical task assignment is one of the core issues of a multi-robot system. In this paper, a multi-robot task assignment strategy based on load balancing is proposed to effectively balance and plan out the execution cost of each robot when it has a large number of working task points. Considering the variability of the execution task cost in practical situations with different task point categories, the multi-robot task assignment (MRTA) problem is transformed into a multiple traveling salesman problem (MTSP) using a multi-angle K-means clustering algorithm. To solve the problem of unbalanced cost consumed by each robot after clustering assignment, which leads to low efficiency of system completion, a two-stage load-balancing strategy is presented. The first stage of this strategy makes a large adjustment to the unbalanced task set, and the second stage achieves a small fine-tuning to the unbalanced task set. The experimental results show that the standard deviation of the cost ratio of each set decreases when four robots perform the task between 100 and 550 work points using the load-balancing strategy. The reduction in standard deviation is between 3.53% and 83.44%. The maximum cost of individual robots decreases between 0.18% and 14.27%. The proposed method can effectively solve the uneven execution cost of each robot in the task assignment process and improve the efficiency of the system in completing tasks.
Nonlinear Multi-Object Differential Game Simulation Model in LabVIEW
Authors: Lisowski Józef
Published: September 2023

This article presents the synthesis of a nonlinear multi-object differential game model in relation to the process of safe ship control in collision situations at sea. Nonlinear dynamic equations of a target ship and linear kinematic equations of passing ships were used to formulate the game state equations. The model of such a differential game was developed using LabVIEW 2022 version software. This was then subjected to simulation tests using the example of a navigational situation in which the target ship passed three encountered ships at a safe distance under the conditions of non-cooperation of ships, their cooperation, and optimal non-game control. The results of the computer simulation are presented in the form of ship trajectories and time courses of individual game control variables. The distinguishing feature of the model built in LabVIEW software is the ability to conduct research in online mode, where the user has the opportunity to track the impact of changes in the model parameters on the course of the differential game simulation on an ongoing basis. Further refinements of the simulation model should concern the larger number of ships and test the sensitivity of the game control quality to inaccuracies in the measured state variables and to changes in the parameters of the ship’s dynamics.
Power Transmission Using Circular Elements Bounded by Given Central Angle in Rolling Contact
Authors: Provatidis Christopher G.
Published: September 2023

In the present study, the concept of utilizing two circular cam-track disks, of the same central angle, in combination with one circular roller is presented. The roller is restrained to move within a vertical groove, and at the same time it rotates with rolling-contact on both cam tracks. When the upper cam is fully travelled by the roller, the same occurs with the lower one, despite their different lengths. Therefore, during the rolling contact, the two cams always sweep the same central angle. The aforementioned configuration of the two circular arcs may be considered as a unit cell, which can be repeated an even number of times, and when folded forms a closed circular groove between two cam-track disks. For better understanding, a manufactured prototype and 3D CAD-models have been developed. The operation of this setup as a gearless automotive differential is demonstrated by performing two bench experiments, which are then explained by a simplified mechanical model. The latter focuses on the implementation of the principle of the inclined plane, in which an upper limit of the inclination angle is imposed in accordance with the coefficient of friction at the friction disks. Previous patents on gearless differentials are discussed and other possible applications in mechanical engineering are outlined.
Moles of Molecules against Mycobacterium abscessus: A Review of Current Research
Authors: Cocorullo Mario , Bettoni Christian , Foiadelli Sara , Stelitano Giovanni
Published: September 2023

Mycobacterium abscessus is an emerging opportunistic pathogen that infects mainly the respiratory tract of individuals with pre-existing clinical pictures. In recent years, the incidence of infections of this microorganism has risen, in particular in patients with cystic fibrosis, leading to an exacerbation of their conditions. The actual therapeutic regimen has low efficacy and is extended for long periods since it is mainly based on a combination of repurposed drugs, generally from treatments of Mycobacterium tuberculosis infections. For this reason, it is necessary to develop new drugs or alternative strategies in order to improve the efficacy and shorten the time of treatments. This review aims to give an overview of drugs in the pre-clinical and clinical phases of evaluation against M. abscessus and the molecules that have been in development for the past five years in the early drug-discovery phase.
Mountain Permafrost: A Reflection on the Periglacial Environment in Mongolia
Authors: Walther Michael , Kamp Ulrich
Published: September 2023

There are different ideas about the classification and distribution of permafrost in Mongolia. Terms such as continuous, discontinuous, sporadic, and isolated permafrost are inconsistently applied; hence, maps of permafrost display different distribution patterns. Particularly, the southern border of the Siberian permafrost in Mongolia is still debated. Furthermore, comparing these maps is challenging when studying impacts of climate change on permafrost. While, without a doubt, Mongolia’s permafrost is in a stage of significant degradation and has receded from vast regions, telling this story is difficult when data are not easily comparable. Today, all permafrost is restricted to Mongolia’s mountains. To better describe permafrost that depends on orography and elevation, we propose to use the more appropriate term ‘mountain permafrost.’ Surprisingly, the term ‘periglacial’ is mostly absent in the literature on Mongolia’s permafrost. We here aim to clarify definitions of terms and hope that future studies will pay attention to both periglacial environments and mountain permafrost.
Real-World Experiences with Taliglucerase Alfa Home Infusions for Patients with Gaucher Disease: A Global Cohort Study
Authors: Revel-Vilk Shoshana , Mansfield Royston , Feder-Krengel Neta , Machtiger-Azoulay Noya , Kuter David , Szer Jeff , Rosenbaum Hanna , Ferreira David Cavalcanti , Ruhrman-Shahar Noa , Wajnrajch Michael , Zimran Ari
Published: September 2023

Taliglucerase alfa is an enzyme replacement therapy approved for Gaucher disease. We assessed the duration/compliance/safety of such home infusions in commercial use in four countries where home infusion programs are available. The treatment duration/compliance study included 173 patients (Israel, 58; US, 61; Brazil, 48; Australia, 6) who received ≥1 taliglucerase alfa home infusion through 6/2021. The median age at home therapy initiation was 38 (range, 2–87) years; 58% were females. The median treatment duration (at home) was 2.7 (range, 0.04–9.0) years. The annual compliance rate was stable (≥95%) throughout the study period. A search of the Pfizer global safety database (through 6/2021), identified 19 adverse events (AEs) as related to “definite home use” and 14 to “possible home use” of taliglucerase alfa; 42.4% of these AEs were serious; none were fatal. Twelve serious AEs in five separate case reports were considered treatment related: one case of chest discomfort/pain and hypertension and one case of erythema associated with a toe blister, for which causality could not be excluded; pain in extremity; projectile vomiting and chills, alongside excessive eye blinking; and an infusion-related AE (pruritus). In conclusion, this real-life global study demonstrated that taliglucerase alfa home infusions are safe with high compliance rates.
Pharmacokinetic and Pharmacogenetic Predictors of Major Bleeding Events in Patients with an Acute Coronary Syndrome and Atrial Fibrillation Receiving Combined Antithrombotic Therapy
Authors: Baturina Olga , Chashkina Maria , Andreev Denis , Mirzaev Karin , Bykova Alexandra , Suvorov Alexandr , Yeryshova Daria , Suchkova Svetlana , Sychev Dmitry , Syrkin Abram
Published: September 2023

Objective: This study’s objective was to evaluate the effects of pharmacokinetic and pharmacogenetic factors on major bleeding in patients with ACS and non-valvular AF receiving combined antithrombotic therapy consisting of rivaroxaban, clopidogrel, and aspirin as part of dual or triple therapy. Methods: A prospective observational study was conducted in two PCI centers in Moscow, the Russian Federation, from 2017 to 2018. One hundred patients with ACS and AF were enrolled. Prospective follow-ups continued for 12 months. Results: A total of 36 patients experienced bleeding events, with 10 experiencing major bleeding based on the BARC scale and 17 experiencing major bleeding based on the ISTH scale. The following predictors associated with an increased number of major bleeding events were identified: for the ISTH scale, a Css min. of rivaroxaban of >137 pg/mL (5.94 OR, (95% CI, 3.13–12.99; p < 0.004)) and carriage of the T allelic variant polymorphism ABCB1 rs4148738 (8.97 OR (95% CI, 1.48–14.49; p < 0.017)), as well as for the BARC scale (5.76 OR (95% CI, 2.36–9.87; p < 0.018)). Conclusions: Measuring residual steady-state rivaroxaban concentrations and determining the carriage of the T allelic variant polymorphism ABCB1 rs4148738 may be applicable to high-risk patients for subsequent antithrombotic therapy modification.
Evaluation of Spatiotemporal Changes in Cropland Quantity and Quality with Multi-Source Remote Sensing
Authors: Liu Han , Wang Yu , Sang Lingling , Zhao Caisheng , Hu Tengyun , Liu Hongtao , Zhang Zheng , Wang Shuyu , Miao Shuangxi , Ju Zhengshan
Published: September 2023

Timely cropland information is crucial for ensuring food security and promoting sustainable development. Traditional field survey methods are time-consuming and costly, making it difficult to support rapid monitoring of large-scale cropland changes. Furthermore, most existing studies focus on cropland evaluation from a single aspect such as quantity or quality, and thus cannot comprehensively reveal spatiotemporal characteristics of cropland. In this study, a method for evaluating the quantity and quality of cropland using multi-source remote sensing-derived data was proposed and effectively applied in the black soil region in Northeast China. Evaluation results showed that the area of cropland increased significantly in the study area between 2010 and 2018, and the proportion of cropland increased by 1.17%. Simultaneously, cropland patches became larger and landscape connectivity improved. Most of the gained cropland was concentrated in the northeast and west, resulting in a shift in the gravity center of cropland to the northeast direction. Among land converted into cropland, unused land, grassland, and forest were the main sources, accounting for 36.38%, 31.47%, and 16.94% respectively. The quality of cropland in the study area generally improved. The proportion of low-quality cropland decreased by 7.17%, while the proportions of high-quality and medium-quality cropland increased by 5.65% and 5.17%, respectively. Specifically, the quality of cropland improved strongly in the east, improved slightly in the southwest, and declined in the north. Production capacity and soil fertility were key factors impacting cropland quality with obstacle degrees of 36.22% and 15.64%, respectively. Overall, the obtained results were helpful for a comprehensive understanding of spatiotemporal changes in cropland and driving factors and can provide guidance for cropland protection and management. The proposed method demonstrated promising reliability and application potential, which can provide a reference for other cropland evaluation studies.
Planting a Linear Vegetation Element in Landscape Using a Forestry and Landscaping Method—Can We Tell Which Deliver Greater Success?
Authors: Lacina Darek , Kupec Petr
Published: September 2023

Since the end of the 20th century, the Czech Republic has been developing an ecological network. Areas of ligneous greenery are being established throughout the landscape. The projects use different sizes of planting material: forestry seedlings and landscaping seedlings. In the South Moravian Region, in the vicinity of the village of Šardice, a series of measurements was carried out in 2016–2019 to compare the vitality of the greenery elements established by each of the methods. The height of the seedlings and trunk diameter were measured for the young trees while the shrubs were monitored for the seedling height only. Mortality was recorded successively for all the seedlings. The forestry method demonstrated greater growing vigour as indicated by the ratio of the trunk diameter increment to height while the landscaping method had lower mortality. In the forestry plantations, high mortality was found especially in poplars, oaks and hornbeams while in the landscaping plantations the poplars and oaks had the highest mortality. Elm, sycamore and poplar trees had the highest increments in the forestry plantations (but the latter was planted at different size). In the landscaping plantations, poplar trees (planted at a different size) delivered the best results, followed by maple, elm and lime trees. Shrub mortality was similar in both types of plantings. Hazel had a very high mortality while ivy, privet and honeysuckle had low mortality. Shrub height gain was higher in fenced forestry plantations. In unfenced landscaping plantations, damage by game was evident.
Polyphenol Analysis via LC-MS-ESI and Potent Antioxidant, Anti-Inflammatory, and Antimicrobial Activities of Jatropha multifida L. Extracts Used in Benin Pharmacopoeia
Authors: Dah-Nouvlessounon Durand , Chokki Michaelle , Agossou Essé A. , Houédanou Jean-Baptiste , Nounagnon Martial , Sina Haziz , Vulturar Romana , Heghes Simona Codruta , Cozma Angela , Mavoungou Jacques François , Fodor Adriana , Baba-Moussa Farid , Suharoschi Ramona , Baba-Moussa Lamine
Published: September 2023

Jatropha multifida L., a plant from the Euphorbiaceae family, is commonly used in Benin’s traditional medicine due to its therapeutic benefits. This study aims to explore the medicinal efficacy of Jatropha multifida L. by evaluating its various biological activities. An initial phytochemical analysis was conducted, following which the polyphenols and flavonoids were quantified and identified using LC-MS-ESI. The antimicrobial efficacy of the extracts was tested using agar diffusion. Their antioxidant capacity was assessed using several methods: DPPH radical reduction, ABTS radical cation reduction, ferric ion (FRAP) reduction, and lipid peroxidation (LPO). Anti-inflammatory activity was determined based on the inhibition of protein (specifically albumin) denaturation. The study identified several phenolic and flavonoid compounds, including 2-Hydroxybenzoic acid, o-Coumaroylquinic acid, Apigenin-apiosyl-glucoside, and luteolin-galactoside. Notably, the extracts of J. multifida demonstrated bactericidal effects against a range of pathogens, with Concentration Minimally Bactericidal (CMB) values ranging from 22.67 mg/mL (for organisms such as S. aureus and C. albicans) to 47.61 mg/mL (for E. coli). Among the extracts, the ethanolic variant displayed the most potent DPPH radical scavenging activity, with an IC50 value of 0.72 ± 0.03 mg/mL. In contrast, the methanolic extract was superior in ferric ion reduction, registering 46.23 ± 1.10 µgEAA/g. Interestingly, the water-ethanolic extract surpassed others in the ABTS reduction method with a score of 0.49 ± 0.11 mol ET/g and also showcased the highest albumin denaturation inhibition rate of 97.31 ± 0.35% at a concentration of 1000 µg/mL. In conclusion, the extracts of Jatropha multifida L. are enriched with bioactive compounds that exhibit significant biological activities, underscoring their therapeutic potential.
Clinical Care Team’s Guide for Awareness on Risk Assessment of Eltrombopag Complicating Acute Kidney Injury in Relapsed Immune Thrombocytopenic Patients: A Case Report
Authors: Hamed Eman Mostafa , Meabed Mohamed Hussein , Ibrahim Ahmed R. N. , Khalaf Ahmed M. , El Demerdash Doaa Mohamed , Elgendy Marwa O. , Saeed Haitham , Mahmoud Tamer M. , Salem Heba F. , Rabea Hoda
Published: September 2023

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder caused by antigen-specific T cells and antiplatelet autoantibodies that inhibit platelet production in the bone marrow or destroy platelets in the spleen. ITP is a form of autoimmunity and is closely associated with inflammation. Corticosteroids are the first-line therapy for ITP, with a total response rate of 53–80%. However, corticosteroid therapy is associated with significant side effects and is often ineffective in patients with corticosteroid-resistant or -intolerant disease. Eltrombopag has been validated as a second-line option in ITP therapy. Despite several studies demonstrating the efficacy and safety of Eltrombopag in immune thrombocytopenia patients, the prevalence of Eltrombopag-induced acute kidney injury has been observed. This case report describes a patient who experienced acute kidney injury during Eltrombopag therapy. A sudden increase in serum creatinine to 6.7 mg/dL and metabolic acidosis occurred after eight weeks of Eltrombopag. The patient’s renal failure had worsened, proteinuria was detected, and emergency hemodialysis was initiated. With vigilant kidney function screening and prompt treatment, the patient’s renal function improved remarkably following cessation of Eltrombopag and initiation of hemodialysis. This case highlights the importance of comprehensive medication history-taking and vigilant kidney function screening in patients receiving Eltrombopag.
A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use
Authors: Funieru Cristian , Tudose Dan Ștefan , Dobrică Bogdan , Săndulescu Mihai , Popovici Ion Alexandru , Slușanschi Emil Ioan , Croitoru Sorin Mihai , Vrînceanu Daniela , Bănică Bogdan , Nicolescu Mihnea Ioan
Published: September 2023

Background and Objectives: Saliva is of utmost importance for maintaining oral health. Management of saliva flow rate deficiency recently includes salivary neuro-electrostimulation. The aim of this paper is to present a new model of salivary pacemaker—the MICROSAL device (MD), an intelligent, miniaturized, and implant-supported oral device used for salivary stimulation. Materials and Methods: This report presents the development, calibration, and first clinical tests which involved the MD. The novel features of this device are the pH sensor and the fact that it communicates with the patient’s smartphone, where oral wetness and pH are graphically exposed. Saliva samples were taken before and after the MD was used on a 68-year-old patient suffering from post-irradiation xerostomia, and albumin and total protein were analyzed. Results: The device uses up to 3 V and time intervals of 2 s seconds for stimulation. The total volume of all saliva samples collected during the clinical trial was almost seven times higher after the device was used. Albumin decreased from a maximum of 0.15 g/dL to 0.04 g/dL, and total proteins from 0.65 g/dL to 0.21 g/dL, after salivary stimulation. Conclusions: The MD increased saliva secretion of the patient, and we are confident it will be a good solution for future management of salivary gland hypofunction.
Analysis of Microstructure Evolution of Co-Cr-Mo Alloy during Isothermal Forging
Authors: Gamin Yury V. , Skugorev Alexander V. , Karashaev Mukhamed M. , Kin Tatiana Y. , Galkin Sergei P. , Mahmoud Alhaj Ali Abdullah , Cheverikin Vladimir V.
Published: September 2023

The article analyzes the microstructure evolution of Co-Cr-Mo alloy during isothermal forging. The process of isothermal forging can be a technological solution to produce a semi-finished product for subsequent deformation processing and obtain a high-quality microstructure that excludes casting defects. Based on analysis of microstructure and phase composition and calculations, the required modes of ingot homogenization are determined. Finite element method simulation of the forging has shown that temperature and deformation conditions make deformation in the single-phase γ-region possible. However, at lower temperatures, σ-phase particles may precipitate at the last steps of deformation. After isothermal forging and water quenching, a mixture of recrystallized and polygonized structures with an average grain size of 5–10 μm and precipitation of ultra-fine dispersed particles of σ-phase (~0.13 μm) at grain boundaries are formed. Isothermal forging in the temperature range of 1100–1200 °C and at low strain rates of up to 1 s−1 allows obtaining a microstructure without pores, cracks, and large inclusions. Thus, it makes it possible to use the forging billet for further deformation by different metal forming methods.
Special Issue “Synthesis of TiO2 Nanoparticles and Their Catalytic Activity”
Authors: Zhou Wei
Published: September 2023

The current advances in the development of technologies for solar light utilization are largely due to the environmental and energy crisis caused by the rapid consumption of fossil fuels, and consequently, various applications have been implemented in domestic heating devices, the field of spaceflight, vehicles with clean energy, self-cleaning devices, the bio-pharmaceutical field, etc [...]
Fabrication of Self-Assembled BiFeO3/CeO2 Nanocatalytic Materials for Efficient Catalytic Dye Degradation
Authors: Li Lin , Li Qi , Wang Dongqing , Zhang Yubo , Li Fei , Zhang Yaru , Jiao Tifeng
Published: September 2023

The catalytic treatment of wastewater serves as an effective way to solve the problem of water pollution, in which non-homogeneous Fenton catalysts are widely used. However, the activity enhancement of non-homogeneous Fenton catalysts still remains a great challenge. Herein, self-assembled BiFeO3/CeO2 nanocatalytic materials with different molar ratios were successfully fabricated by a suspension blending method, following which the structure evolution was determined by various characterizations. The catalytic degradation of methylene blue (MB), rhodamine B (RhB), and saffron T (ST) were performed over the BiFeO3/CeO2 nanocatalytic materials. It was found that the 0.2BiFeO3:0.8CeO2 nanocatalytic materials exhibited an 80.8% degradation efficiency for RhB. The 0.6BiFeO3:0.4CeO2 nanocatalytic materials reached 81.1% and 48.7% for ST and MB, respectively. The BiFeO3/CeO2 nanocatalytic materials also showed a good stability during several cycles. The combination of CeO2 with BiFeO3 led to an enhanced activity for dye degradation, probably due to the electron transfer from ≡Fe2+ to ≡Ce4+. This study provides a new approach to dye degradation by using Fenton catalytic systems.
Application of Single Particle ICP-MS for the Determination of Inorganic Nanoparticles in Food Additives and Food: A Short Review
Authors: Loeschner Katrin , Johnson Monique E. , Montoro Bustos Antonio R.
Published: September 2023

Due to enhanced properties at the nanoscale, nanomaterials (NMs) have been incorporated into foods, food additives, and food packaging materials. Knowledge gaps related to (but not limited to) fate, transport, bioaccumulation, and toxicity of nanomaterials have led to an expedient need to expand research efforts in the food research field. While classical techniques can provide information on dilute suspensions, these techniques sample a low throughput of nanoparticles (NPs) in the suspension and are limited in the range of the measurement metrics so orthogonal techniques must be used in tandem to fill in measurement gaps. New and innovative characterization techniques have been developed and optimized for employment in food nano-characterization. Single particle inductively coupled plasma mass spectrometry, a high-throughput nanoparticle characterization technique capable of providing vital measurands of NP-containing samples such as size distribution, number concentration, and NP evolution has been employed as a characterization technique in food research since its inception. Here, we offer a short, critical review highlighting existing studies that employ spICP-MS in food research with a particular focus on method validation and trends in sample preparation and spICP-MS methodology. Importantly, we identify and address areas in research as well as offer insights into yet to be addressed knowledge gaps in methodology.
The Impact of Transformational Leadership in the Nursing Work Environment and Patients’ Outcomes: A Systematic Review
Authors: Ystaas Line Miray Kazin , Nikitara Monica , Ghobrial Savoula , Latzourakis Evangelos , Polychronis Giannis , Constantinou Costas S.
Published: September 2023

Background: With the increasingly demanding healthcare environment, patient safety issues are only becoming more complex. This urges nursing leaders to adapt and master effective leadership; particularly, transformational leadership (TFL) is shown to scientifically be the most successfully recognized leadership style in healthcare, focusing on relationship building while putting followers in power and emphasizing values and vision. Aim: To examine how transformational leadership affects nurses’ job environment and nursing care provided to the patients and patients’ outcomes. Design: A systematic literature review was conducted. From 71 reviewed, 23 studies were included (studies included questionnaire surveys and one interview, extracting barriers and facilitators, and analyzing using qualitative synthesis). Result: TFL indirectly and directly positively affects nurses’ work environment through mediators, including structural empowerment, organizational commitment, and job satisfaction. Nurses perceived that managers’ TFL behavior did not attain excellence in any of the included organizations, highlighting the necessity for additional leadership training to enhance the patient safety culture related to the non-reporting of errors and to mitigate the blame culture within the nursing environment. Conclusion: Bringing more focus to leadership education in nursing can make future nursing leaders more effective, which will cultivate efficient teamwork, a quality nursing work environment, and, ultimately, safe and efficient patient outcomes. This study was not registered.