bluuebunny/crossref_metadata_2025 huggingface dataset:
Ecotoxicidade do ibuprofeno em concentrações ambientalmente relevantes e não relevantes sobre a germinação e desenvolvimento inicial de plântulas de trigo (Triticum aestivum L.)
Authors: Silva Leonardo Mendes da , Silva Fábio Júnio da , Cunha Leidiane Aparecida da , Galisa Natalia Rosa
Published: October 2023

Este trabalho teve como objetivo avaliar os efeitos tóxicos do ibuprofeno em concentrações ambientalmente relevantes (0,02 e 0,20 mg/L-1) e não relevantes (600 mg/L-1) sobre o modelo vegetal Triticum aestivum (trigo). As sementes foram expostas a diferentes concentrações, e avaliaram-se a porcentagem de germinação (PG%), o índice de velocidade de germinação (IVG) e o comprimento da raiz e da parte aérea das plântulas, bem como o índice de toxicidade. A PG% foi afetada somente pela concentração mais alta (600 mg/L-1), reduzindo-se em 20%. A concentração de 0,20 mg/L-1 não afetou a germinação, mas reduziu significativamente o IVG em 17,14%. Além disso, ambas as concentrações afetaram significativamente o comprimento da raiz e da parte aérea das plântulas. O índice de toxicidade revelou que as concentrações de 0,02 e 0,20 mg/L-1 foram tóxicas para o trigo em 5,79% e 13,37%, respectivamente. Os resultados evidenciam que o ibuprofeno é capaz de afetar os organismos vivos, mesmo em concentrações mínimas, o que ressalta a necessidade de monitorar e controlar sua presença em sistemas aquáticos e terrestres.
Avifauna de um trecho do Rio Itajaí do Norte, divisa dos municípios de Santa Terezinha e Itaiópolis, Santa Catarina, sul do Brasil
Authors: Meyer Douglas
Published: October 2023

Por meio de 52 amostragens de campo, entre os anos de 2020 e 2023, foram registradas 282 espécies de aves em uma porção do Rio Itajaí do Norte, entre os municípios de Itaiópolis e Santa Terezinha (SC). Das espécies registradas, 16 merecem destaque por estarem classificadas em algum nível de ameaça de extinção na lista estadual, nacional ou internacional e duas são raras no estado de Santa Catarina. A região do estudo é considerada prioritária para a preservação da biodiversidade da mata atlântica, e o resultado encontrado no presente trabalho servirá de base para auxiliar na elaboração de estratégias de preservação e na conservação das espécies
Plantas aquáticas em ambientes antropizados e naturais: perspectivas filogenéticas
Authors: Machado-Filho Hermes , Zickel Carmen Sílvia
Published: October 2023

Com base na correlação esperada, de que condições antrópicas reduzem a diversidade filogenética, este estudo comparou assembleias de plantas aquáticas, naturais e antropizadas, a fim de perceber tal padrão. Para isso, foram calculadas métricas filogenéticas para testar a hipótese, recorreu-se ao teste de Mantel entre a diversidade filogenética e a distância geográfica das áreas analisadas, fez-se uma análise de similaridade para determinar as conexões florísticas, além da detecção das síndromes de dispersão dos táxons avaliados. Como resultados, observou-se que, apesar de as áreas naturais e antropizadas apresentarem diferença significativa em termos de riqueza, são compostas pelas mesmas famílias e gêneros botânicos, ou seja, independentemente do status de conservação da área ou da distância geográfica. Há aceitação de um modelo nulo, em que o sucesso da dispersão dos grupos avaliados foi determinante para a explicação dos fatos.
DESIGN DE JOIAS: AÇÕES DISRUPTIVAS VOLTADAS À SUSTENTABILIDADE NO BRASIL CONTEMPORÂNEO
Authors: Aryuska Aryelle Santos Sousa da Silva  , Thamyres Oliveira Clementino
Published: October 2023

Este artigo consiste em um levantamento de formas de descontinuidade no design de joias, com base nos conceitos do ecodesign e do design para a sustentabilidade, tendo por objetivo contribuir com a busca pela diminuição dos impactos ambientais gerados por essa cadeia, além de difundir o que vem sendo realizado em diferentes contextos do país. Para isso, realizaram-se uma revisão bibliográfica e um levantamento sistêmico em publicações de uma revista e anais de um encontro em sustentabilidade dos anos de 2018 a 2022, além dos anais do último Simpósio Internacional de Ourivesaria, Joalheria e Design (II SIDGEM), visando buscar relatos e pesquisas acerca de descontinuidades no design de joias, por meio das palavras[1]chave: “design de joias”, “joalheria”, “sustentabilidade”, “joia e gemas”. Com base no levantamento, foram selecionados 14 artigos que serviram de fundamento para a seleção de casos relevantes para este estudo e a construção do quadro síntese apresentado ao final.
SELEÇÃO DE MATERIAIS NO DESIGN DE EMBALAGENS: FATORES INFLUENCIADORES NO MERCADO BRASILEIRO DE CAFÉ
Authors: André Mol  , Maria Regina Álvares Correia Dias  , Lia Paletta Benatti
Published: October 2023

A seleção de materiais para embalagens de café é o ponto central deste artigo, contextualizado no mercado brasileiro, maior produtor e um dos maiores consumidores mundiais. As formas de apresentação das embalagens ao consumidor, a amplitude de público e o envolvimento de produtores e marcas permitem ilustrar as cadeias de produção e consumo e as etapas do ciclo de vida dos produtos. A metodologia empregada é qualitativa, partindo da pesquisa bibliográfica e documental, referente ao mercado de café e ao uso de materiais no desenvolvimento de embalagens, passando à síntese gráfica das cadeias para identificação de etapas e fluxos que permitiram indicar fatores de influência para seleção de materiais nos projetos de design. Como conclusão apontou-se a possibilidade de replicar esses fatores para outros mercados, com maior ou menor impacto.
A milonga como rastro da participação do negro na cultura pampiana
Authors: Cleusa Maria Gomes Graebin  , Jucelino Viçosa de Viçosa
Published: October 2023

Um trabalho de memória possibilita que se tenha uma compreensão a respeito da trajetória de um grupo social, por meio da noção de que lembrar e esquecer são etapas de um mesmo processo; com isso, busca-se nos vestígios documentais algo capaz de fazer ressurgir algum acontecimento ou fenômeno ocorrido ao longo do tempo no âmbito de uma comunidade, de um lugar, com um determinado povo.  Este artigo aborda, com base no gênero musical milonga desenvolvido na tríplice fronteira entre Brasil, Argentina e Uruguai, a inserção e a presença dos negros no Pampa, no contexto de uma tradição idealizada apenas no ser humano de cor branca, centrada na figura do gaucho/gaúcho ligado ao campo, proprietário rural, de ascendência espanhola ou portuguesa, ideário depois acrescido de alemães, italianos, entre outros, invisibilizando a presença dos povos originários e dos africanos escravizados e seus descendentes.
Correlation between dental crown’s color and pulse oximetry interpretation in teeth submitted to bleaching procedures
Authors: Igor César Ribeiro de Carvalho  , Ana Helena Gonçalves Alencar  , Lorena Ferreira de Lima  , Isabella Negro Favarão  , Julio Almeida Silva  , Cyntia Rodrigues de Araújo Estrela  , Carlos Estrela
Published: October 2023

To evaluate the correlation between the dental crown’s color and the pulse oximeter result in healthy teeth before and after 30 days of the end bleaching procedures. Material and methods: The dental crown’s color of 70 healthy maxillary central incisors were evaluated using a spectrophotometer and the oxygen saturation level of the pulp was recorded using a pulse oximeter. The bleaching was performed using the combined technique, with 35% hydrogen peroxide bleaching gel, in the office stage, and 10% carbamide peroxide, in the at-home, for 16 days. The variables symmetry was verified by the Kolmogorov Smirnov test, and the quantitative variables described by mean and standard deviation. The correlation between quantitative variables was established using Pearson’s correlation coefficient. The significance level considered was 5%. Results: A significant change was observed between values recorded by the pulse oximeter before (85.0% ± 4.1) and after (86.4% ± 2.3) 30 days of the end. Thirty days after the end of the bleaching procedures, the dental crowns were lighter with the difference between L*s equal to 1.4, more greenish with a difference between a*s equal to 1.3, and more bluish with a difference between b*s equal to -7.2. There was no correlation between the values of coordinates L*, a* and b* and the results recorded by the pulse oximeter in the initial period, respectively, or 30 days after the bleaching procedures, respectively. Conclusion: Changes in pulse oximeter recordings did not correlate with the change in the dental crown’s color promoted by bleaching procedures.
Thermographic analysis during rapid maxillary expansion
Authors: Melisssa Galarza Rodriguez  , Mauren Abreu de Souza  , Giovanna Simião Ferreira  , Layza Rossatto Oppitz  , Cristiano Miranda de Araujo  , Sérgio Aparecido Ignácio  , Elisa Souza Camargo
Published: October 2023

The aim of this study was to evaluate the temperature of the palate during rapid maxillary expansion through thermal imaging. Material and methods: Modified Hyrax palatal expander was installed in 11 patients. Thermal images of the palate were obtained using the FLIR A325 infrared camera. The evaluation was carried out 6 times: T0 – without activation; T1 – 4; T2 – 8; T3 – 12; T4 – 16; T5 – 30 screw activations. The thermographic images were analyzed qualitatively by visualizing the colors and quantitatively, by measuring the temperature of the palate at points Sp1, Sp2, Sp3 and Line 1 (Li1), in the midpalatal suture and Sp4 and Line 2 (Li2) in the lateral region of the hard palate. ANOVA and Games-Howell statistical tests were used. Results: When evaluating each region over time, in Sp4 and Li2, it was observed a lower temperature in T5 than in T1 and in Li1 a lower temperature in T5 than in T4 (p<0.05). Conclusion: Similar temperatures were observed in the central and lateral regions of the palate. Higher temperatures were recorded at the time of the first activations and lower temperatures were recorded on the 14th day. > <0.05). Conclusion: Similar temperatures were observed in the central and lateral regions of the palate. Higher temperatures were recorded at the time of the first activations and lower temperatures were recorded on the 14th day.
Morphological and morphometric characteristics of labial-cervical-vertical groove in upper central incisor
Authors: Fabiana Cervo de Barros  , Luiza Marins de Oliveira Cortinhas  , Anne Luise Scabell Almeida  , Laura Padula  , Patrícia Luise Scabell Evans
Published: October 2023

The labial-cervical-vertical groove (LCVG) is a developmental dental anomaly that may be present in the maxillary central incisors (UCI) which can affect periodontal health, facilitate the occurrence cervical decay, and compromise the aesthetics of the gingival contour. A LCVG can present different magnitudes and, when severe, it can impact the prognosis of the affected tooth. Objective: The objective of this study was to investigate the prevalence, extent, and depth of labial-cervical-vertical groove (LCVG) in maxillary central incisors (UCI) from the Human Tooth Bank of Rio de Janeiro State University Dental School, aiming to provide a better understanding of this anomaly and thus to contribute to an accurate differential diagnosis and appropriate dental planning. Material and methods: Ninety-seven dental elements, belonging to the Human Tooth Bank of Rio de Janeiro State University Dental School, were inspected, for presence of LCVG. For analysis of this morphological alteration, the following measurements were registered in millimeters: the total length (measured from the coronal to the apical limits of the defect); its extension in the crown (measured from the defect’s coronal limit to the cementum enamel junction (CEJ)); its extension in the root (measured from the defect’s apical limit to the CEJ) and depth (measurement of the groove’s invagination toward the root canal) of LCVG in each tooth. Results: The prevalence of LCVG in our sample was 7.21%. The average measures observed for the LCVG were: 6.43 (± 1.81) mm of total of length, 2.86 (± 1.68) mm of extension in the root; 3.57 (± 0.98) mm of extension in the crown; and <1 to 1mm of depth. Conclusion: These findings contribute with knowledge on of the detail, of extent and depth of LCVG in UCI, providing the clinician with information that can favor diagnosis and maintenance of teeth with this anomaly.
Influência do clareamento dentário de consultório na dureza superficial de três resinas compostas: um estudo in vitro
Authors: Joselúcia da Nóbrega Dias  , Wanderson Talles do Nascimento Pereira Santos  , Marília de Lima Soares  , Márcia de Almeida Durão  , Ana Margarida dos Santos Melo  , Isauremi Vieira de Assunção
Published: October 2023

É cada dia mais frequente a busca de pacientes que apresentam restaurações em resina composta pelo clareamento dentário, seja ele pela técnica caseira ou de consultório, sendo cada vez mais importante o conhecimento acerca das alterações que ocorrem nesses materiais restauradores. Objetivo: Avaliar a dureza superficial de três resinas compostas (Filtek Z350 – 3M ESPE, Zirconfil – Technew, Vittra – FGM) após clareamento dentário de consultório à base de peróxido de hidrogênio 40%. Material e métodos: Foram confeccionados 60 corpos de prova (6,0 x 2,0 mm), sendo 20 de cada material restaurador (n=20). Após acabamento e polimento, os espécimes foram divididos aleatoriamente em dois grupos para cada material restaurador (n=10). O grupo controle (G1-C) foi mantido em saliva artificial. O grupo experimental (G2-E) foi submetido ao gel clareador de consultório à base de peróxido de hidrogênio 40% de acordo com a indicação do fabricante. Efetuou-se a análise da dureza por meio do teste de Vickers. A análise comparativa entre o grupo controle e o grupo experimental para cada resina foi feita por intermédio do teste t de Student, enquanto a comparação entre as resinas dentro de cada grupo foi analisada pelo teste Anova. Resultados: Os valores de dureza para as resinas testadas foram estatisticamente mais elevados no grupo controle. A maior diferença nos valores das médias entre os grupos ocorreu na resina Z350XT. Conclusão: O uso do peróxido de hidrogênio 40% pela técnica de consultório promoveu mudanças significativas na dureza superficial das resinas testadas. Além disso, a resina Z350XT apresentou dureza superior às demais, porém foi a mais afetada pelo agente clareador.
Different managements for surgical approaches in the aesthetic and functional treatment of type IB altered passive eruption
Authors: Karine Guedes Escobar  , Eduarda Cardoso de Oliveira  , Eduardo Trota Chaves  , Gabriel Bittencout Damin  , Edvin Walter Brito Gomes  , Bruna de Oliveira Freitas  , Edson Vargas Nunes  , Thiago Azario de Holanda  , Thiago Marchi Martins
Published: October 2023

Aesthetics has been one of the most discussed and explored subjects in today’s dentistry. Therefore, the search for procedures aimed at facial harmonization has been more frequent in dental offices. The gingival smile is characterized by excessive gingival exposure to the smile being one of the main complaints of the patients who seek a dental surgeon in order to obtain facial aesthetics, being able to present different causes. It is extremely important to correctly diagnose each case so that the correct etiology is stable and successful in the treatment to be performed. Objective: In the present paper, two clinical cases of patients with complaints of gingival smile and short teeth were reported in which the etiology of both was type IB altered passive eruption. Case report: Due to the individual characteristics of each patient, each case was solved with different surgical approaches. In the first case, the patient had a thick periodontium and therefore the clinical crown lenghtening procedure was performed through the internal bevel gingivoplasty with osteotomy and osteoplasty. In the second case, the patient had a thin periodontium, and it was possible to perform a clinical crown lenghtening using the flapless technique. Conclusion: Therefore, although both cases present the same etiology, different periodontal surgical techniques were used, which allowed for satisfactory results for the patients.
Shade selection for natural tooth color replication on porcelain laminate veneers
Authors: Leonardo Fernandes da Cunha  , Ricardo Susin Schelbauer  , Helton Costa  , Lucas Fernando Tabata  , Daniella Birnbaum Pessoa de Mello  , Patrícia Valeria Manozzo Kunz  , Samantha Schaffer Pugsley Baratto  , Flares Baratto-Filho  , Isabela Ribeiro Madalena
Published: October 2023

The final color of dental ceramics depends on different factors such as light source, substrate, and selected material (thickness, contour, and texture). Objective: To report a clinical case in which a predictable protocol is used to optimize the final color of porcelain laminate veneers. Case report: A male patient attended the dental clinic dissatisfied with the composite resin restorations made on his upper anterior teeth. After anamnesis and clinical examination, it was suggested that the resin restorations be replaced by laminated porcelain veneers. A diagnostic wax-up was performed. The mock[1]up was also used to evaluate the aesthetic length for replicating the details of the incisal edge and the shape and size of the embrasures. The shade was selected before composite resin removal to avoid dehydration of the dental substrate. A photograph was taken to guide the selection of colors in different thirds. After removing the restorations, another photograph was taken to evaluate the color of the substrate. The impression was taken with 000 retractor wire and addition silicone. The laminates were made with pressed ceramic and feldspathic porcelain veneers were subsequently applied by layering the layers of dentin, incisal edge and enamel based on the waxing diagnosis. After approval by the patient, a conventional cementation technique was performed. The occlusal adjustment was made with rubber polishing cups and the anterior and lateral guides were checked. Conclusion: The protocol recommended for successful selection of the color of a porcelain laminate relies on the combination of knowledge of concepts, resources such as shade guides, spectrophotometers, and photographs, and porcelain application and characterization techniques performed by the technician and luting techniques by the dentist.
Fotobiomodulação no tratamento de mucosite oral induzida por terapia antineoplásica: relato de caso
Authors: Fernanda Mombrini Pigatti  , Larissa Pascoal de Souza Oliveira  , Francielle Silvestre Verner
Published: October 2023

A mucosite oral (MO) é uma complicação corriqueira durante o tratamento antineoplásico. Dentre seus sinais e sintomas, destacam-se eritema, ulceração, hemorragia, edema e dor. A fotobiomodulação é uma alternativa que minimiza os efeitos deletérios decorrentes das terapias antineoplásicas e atua nas limitações impostas pela condição global, permitindo, assim, a manutenção da qualidade de vida. Objetivo: Relatar o caso de uma paciente oncológica que apresentou mucosite oral em consequência do tratamento antineoplásico e ressaltar o uso da fotobiomodulação no tratamento dessas lesões. Relato de caso: Realizou-se o acompanhamento de uma paciente em tratamento de radioterapia para câncer de cabeça e pescoço que foi submetida à fotobiomodulação no tratamento das lesões de MO, com a utilização de um aparelho de laser de baixa potência (Laser Duo – MMOptics, São Carlos, SP, Brasil. Potência: 0,1 W (100 mW) e área do spot: 0,03 cm²). Observou-se que, com o andamento da radioterapia isolada, sem a realização concomitante da fotobiomodulação, houve o desenvolvimento de complicações orais decorrentes do tratamento, sendo a mucosite oral de maior efeito clínico. No entanto, com o uso do laser de baixa potência, a diminuição da gravidade das lesões e da dor foi notável, o que contribuiu para redução da disfagia, propiciando uma melhora da condição sistêmica durante o tratamento. Resultados: Os resultados encontrados estão em concordância com a literatura, na qual há relatos de que a terapia com laser tem se mostrado um método bastante eficiente e promissor no tratamento da mucosite oral, visto que diminui a dor e acelera o processo de cicatrização das lesões. Conclusão: O uso terapêutico do laser de baixa potência foi capaz de promover a cicatrização das lesões de MO e reduzir a sintomatologia, contribuindo para a melhora da alimentação e, por consequência, do estado de saúde geral da paciente, o que contribuiu para a continuidade do tratamento antineoplásico, possibilitando sua finalização.
Hsa_circ_0001687 Function as a ceRNA to Facilitate Hepatocellular
Carcinoma Progression via miR-140- 3p/FOXQ1 Axis
Authors: You Song , Cheng Niangmei , Wang Fei , Zheng Xiaoyuan , Wang Yingchao , Zhao Bixing , Liu Jingfeng
Published: October 2023

Background:

Increasingly convincing evidence has revealed that circular RNAs
(circRNAs) are critical regulatory components of hepatocellular carcinoma (HCC) genesis.
However, the expression of circRNAs in HCC and the relevance of circRNAs to HCC progression
remain largely unexplained.

Methods:

qRT-PCR or western blotting was utilized to confirm circ_0001687, miR-140-3p, and
Forkhead Box q1 (FOXQ1) levels in HCC tissues or cells. Cell proliferation ability was evaluated
via CCK-8 and colony formation assay. The correlation of circ_0001687 or FOXQ1 and miR-140-
3p was determined using dual luciferase reporter assay. Nude mice xenograft tumor model was
constructed to verify the effect of circ_0001687 on tumor growth.

Results:

Circ_0001687 was elevated in HCC. Function assays and the nude mice xenograft tumor
model indicated that circ_0001687 acts as a promoting gene in HCC to regulate the proliferation of
the tumor cell and foster tumor growth. Further mechanistic exploration revealed that the tumor
growth-promoting mechanism of circ_0001687 relied on blocking the inhibitory effect of miR-140-
3p on FOXQ1 and activating FOXQ1 expression.

Conclusion:

This research indicated the role of circ_0001687/miR-140-3p/FOXQ1 network in
regulating HCC development. These may provide new insights into the treatment of HCC.
Recent Updates in Inhalable Drug Delivery System against Various
Pulmonary Diseases: Challenges and Future Perspectives
Authors: Chaudhary Kabi Raj , Singh Karanvir , Singh Charan
Published: October 2023

In the current scenario, pulmonary disease has become a prime burden for morbidity and
mortality alongside tremendous social and economic crises throughout the world. Numerous conventional
drug delivery system and treatment approach targeting the respiratory region has been driven
out. However, effective and accurate recovery has not been achieved yet. In this regard, nanotechnological-
based inhalable drug delivery strategy including polymeric, lipidic, or metallic-based respirable
microparticles plays an indispensable role in circumventing numerous challenges faced during
traditional treatment. Excellent aerodynamic performance leads to enhanced lung targetability, reduced
dosing frequency and hence systemic toxicities, as well as improved pharmaceutical attributes,
and therefore pharmacokinetic profiles are interminable factors associated with nanotechnologicalbased
inhalable delivery. In this review, we comprehensively explored recent advancements in nanotechnologically
engineered inhalable formulations targeting each of the mentioned pulmonary diseases.
Moreover, we systematically discussed possible respiratory or systemic toxicities about the indeterminate
and undefined physicochemical characteristics of inhaled particles.
Thiazolidinedione as a Promising Medicinal Scaffold for the Treatment of
Type 2 Diabetes
Authors: Singh Gurvinder , Kumar Rajesh , D.S. Desna , Chaudhary Manish , Kaur Charanjit , Khurrana Navneet
Published: October 2023

Background:

Thiazolidinediones, also known as glitazones, are considered as biologically active scaffold and a well-established class of anti-diabetic agents for the treatment of type
2 diabetes mellitus. Thiazolidinediones act by reducing insulin resistance through elevated peripheral glucose disposal and glucose production. These molecules activate peroxisome proliferated activated receptor (PPARγ), one of the sub-types of PPARs, and a diverse group of its hybrid have also shown numerous therapeutic activities along with antidiabetic activity.

Objective:

The objective of this review was to collect and summarize the research related to the
medicinal potential, structure-activity relationship and safety aspects of thiazolidinedione analogues designed and investigated in type 2 diabetes during the last two decades.

Methods:

The mentioned objective was achieved by collecting and reviewing the research manuscripts, review articles, and patents from PubMed, Science Direct, Embase, google scholar and
journals related to the topic from different publishers like Wiley, Springer, Elsevier, Taylor and
Francis, Indian and International government patent sites etc.

Results:

The thiazolidinedione scaffold has been a focus of research in the design and synthesis
of novel derivatives for the management of type 2 diabetes, specifically in the case of insulin resistance. The complications like fluid retention, idiosyncratic hepatotoxicity, weight gain and
congestive heart failure in the case of trosiglitazone, and pioglitazone have restricted their use.
The newer analogues have been synthesized by different research groups to attain better efficacy
and less side effects.

Conclusion:

Thus, the potential of thiazolidinediones in terms of their chemical evolution, action
on nuclear receptors, aldose reductase and free fatty acid receptor 1 is well established. The
newer TZD analogues with better safety profiles and tolerability will soon be available in the
market for common use without further delay.
Burden and Coping Strategies of Hypoglycemia in People with Diabetes
Authors: Liakos Aris , Karagiannis Thomas , Avgerinos Ioannis , Tsapas Apostolos , Bekiari Eleni
Published: October 2023

Hypoglycemia is a limiting adverse effect of glucose-lowering medications and particularly insulin replacement therapy. This review provides insights into the burden of hypoglycemia in the management of diabetes and outlines strategies available to reduce the risk of hypoglycemia and improve patients’ well-being. People with type 1 diabetes are primarily affected by
hypoglycemic episodes which are associated with direct physical harms like injuries and cardiac
events as well as indirect psychosocial consequences including constant anxiety, absenteeism,
increased healthcare costs and overall poorer quality of life. These complications are more prominent amongst individuals with hypoglycemia unawareness or overnight hypoglycemia and could
even extend to caregivers such as parents of children with diabetes. Patients experiencing frequent or severe hypoglycemic events might also develop a pathological fear of hypoglycemia
and adopt aberrant behaviors intending to maintain higher blood glucose levels. Modern pharmaceutical options with a safer profile in terms of hypoglycemia are available including novel basal
insulins with lower rates of nocturnal hypoglycemia along with ultra-rapid-acting insulin analogs
with a shorter duration of action that might avert late post-meal hypoglycemia. Continuous glucose monitoring and sensor-augmented insulin pump therapy with low glucose suspend technology can also prevent hypoglycemia, although concerns about cost and patient satisfaction remain. Advancements in insulin therapy and technological modalities should be coupled with ongoing education and support for patients to become co-managers of their disease and reduce the
risk of hypoglycemia.
Design, Synthesis, Evaluation and Toxicity Studies of Novel Acridine
Derivatives in Zebra Fish Larvae
Authors: Ramachandran Surajambika Remya , Natarajan Ramalakshmi , Nagarajan Nalini
Published: October 2023

Background:

Alzheimer’s disease (AD) is a complex neurodegenerative condition for
which a single protein-targeting medication is not enough to provide a cure. All the medications
now available for AD are palliative. FDA has approved five medications for the treatment of AD,
i.e., tacrine, donepezil, galantamine, rivastigmine, and memantine. Due to hepatotoxicity, tacrine is
no longer utilized in clinical practice. Due to the lack of therapeutic efficiency of single-target medications and the multifaceted etiology of AD, multitarget-directed ligands have been developed.

Objectives:

The present research focused on incorporating a flavone nucleus into the amino group
of 9-amino acridine nucleus to make it an acetylcholinesterase (AChE) and butyryl cholinesterase
inhibitor (BuChE) with less toxicity

Methods:

We designed and synthesized ten flavone-substituted acridine derivatives and evaluated
them for in vitro AChE and BuChE inhibitory activity. Molecular modeling studies were conducted using AutoDock Vina with hAChE (PDB ID: 4EY7) and hBuChE (PDB ID: 4TPK). The
toxicity profile of the most active novel compound tested on zebrafish larvae for determining the
liver and cardiac toxicity and LD50 value of the compound were determined.

Results:

In vitro AChE and BuChE inhibitory study by Ellman assay showed acceptable results.
The compound AF2 showed the highest activity with an IC50 value of 0.99 ± 0.1 µM for AChE
and 1.78 ± 0.19 for BuChE. The in vivo acute toxicity studies conducted on zebra fish larvae did
not show cardiac and hepatotoxicity, and the LD50 value was found to be 1000 µL

Conclusion:

The results highlighted the AChE and BuChE inhibitory effects of the novel acridine-flavone hybrids, and they can be promising multitarget-directed ligands for AD.
Important Regulatory Guidelines on Natural Products
Authors: Sahu Abhisar , Srivastava Nimisha , Jena Devashish , Singh Aayushee , Kumar Satya , Chauhan Iti
Published: October 2023

Ayurvedic cosmeceuticals are alluded to as products of various passable magnificence
substances to shape the base in which one or more ayurvedic parts are utilized to give benefits
and various ailments. The Drugs and Cosmetics Act of 1940 controls the approaches concerning
the making, dealing, amassing, allotment, and importing of drugs in essentially a comparable
manner to radiance care things in India. Quality control and assessment of Ayurvedic drugs must
ensure the effectiveness of the drug. Given their crucial role, it involves evaluating their physical, chemical, and physiochemical qualities, as well as conducting in-vitro and in-vivo tests. Natural ingredients have consistently been our primary source of medicines, and dosage forms determine how drug molecules or plant components are delivered to the site of action within the
body. Good agricultural and collection practices (GACP) rules have been given by the WHO
(World Health Organization) for the differentiation and planning of regular items. There are primarily two legal regulatory bodies within the AYUSH (Ayurveda, Yoga and Naturopathy,
Unani, Siddha, and Homeopathy) sector i.e., Central Council of Indian Medicine (CCIM) and
the Central Council of Homeopathy.
Reviewing Expert Attitudes Toward Quaternary Prevention using
Traditional Medicine: A Qualitative Study
Authors: Mehrolhassani Mohammad Hossein , Nia Rahil Ghorbani , Vali Leila , Shaabani Yousef
Published: October 2023

Introduction:

Traditional medicine is based on knowledge, skills, and practices relying on the theories, beliefs, and indigenous experiences of different cultures that has a healthoriented and holistic view. With a holistic and health-oriented approach, quaternary prevention
also seeks to prevent harm to the patient.Patient harm can be prevented by using efficient methods of traditional medicine and limiting the use of ineffective and harmful methods.

Methods:

The quantitative design of the study was conducted using a phenomenological approach among the faculty members of the Faculty of Traditional Medicine of Kerman University of Medical Sciences. Semi-structured interviews were conducted with the participation of 12
individuals selected using purposeful sampling. Content analysis was used to analyze the data.
The codes were categorized based on their differences or similarities.

Results:

Six main themes were identified: prevention, patient benefit, quality of service, patient
harm, rules and regulations, and financial burden. 18 sub-themes were extracted.

Conclusion:

Healthcare providers must protect their patients from the harms and costs of unnecessary diagnostic, therapeutic, and preventative measures. It is likely that adopting effective executive mechanisms, rules, and regulations focusing on the principle of patient benefit can lead
to the implementation of a combination of traditional medicine and modern medicine on an extensive scale, aiming to reduce patient harm.
Effects of the Biological Diversity (Amendment) Bill, 2021 on India's
AYUSH Industry
Authors: Singh Preet Amol
Published: October 2023

Background:

Some of the most well-known ancient medical systems in India include
Ayurveda, Yoga, Unani, Siddha, and Homoeopathy (AYUSH), whose medications are made
primarily from medicinal plants gathered from forests. The Biological Diversity Act, of 2002
was created in India to carry out the 1992 United Nations Convention on Biological Diversity
(CBD). The CBD aims for a sustainable, equitable, and shared distribution of benefits resulting
from the use of biological resources and traditional knowledge. With one of its goals being to
encourage the cultivation of medicinal plants, the Biological Diversity (Amendment) Bill, 2021,
which proposes to amend the Biological Diversity Act of 2002, has been adopted by the lower
house (Lok Sabha) of the Indian parliament.

Objective:

The goal of the study is to examine how the amendment will affect the AYUSH sector, which also happens to be the source of India's traditional medicines.

Results:

A distinction between cultivated and wild medicinal plants has been made, with cultivated medicinal plants being excluded from the access and benefit-sharing (ABS) mechanism
upon acquiring the certificate of origin. This can give rise to false claims by the traders and manufacturers that their medicinal plants are cultivated. According to the most recent modification,
the majority of traditional knowledge employed in the AYUSH systems of medicine is codified.
There's a potential that the majority of people who have traditional knowledge will not be eligible for the benefits. The other argument is that eliminating AYUSH practitioners, growing medicinal plants, and codifying traditional knowledge from access and benefit sharing, would promote foreign investment in the AYUSH sector.

Conclusion:

This amendment must, in practice, ensure that tribes and vulnerable people profit
from the sale of medicinal forest products, and decriminalising certain clauses actually advances
AYUSH, and simplifies business operations. Striking a balance between encouraging economic
growth and maintaining the long-term preservation of India's biodiversity is necessary.
Quality by Design-driven Development of 5-fluorouracil Loaded
Mucoadhesive Microparticulate Drug Delivery Systems for Effective
Chemotherapy for Colorectal Cancer
Authors: Jena Goutam Kumar , Patra Chinam Niranjan , Jammula Sruti , Shree Dipthi , Sahoo Laxmidhar , Patnaik Aiswarya , Nayak Chandan Kumar
Published: October 2023

Aims:

To enhance oral bioavailability and decrease the dosing frequency of 5-Fluorouracil

Background:

Cancer is one of the most dreadful diseases for which complete cures are not possible, but
colorectal cancer is completely curable if diagnosed at an early stage. If diagnosed in late-stage, 5-Fluorouracil (5-FU) is mostly recommended for its effective treatment, but the challenges associated with this
drug are short elimination half-life, severe side effects, as well as non-specificity. The challenges can be
better addressed by fabricating microbeads using the QbD approach. To enhance the oral bioavailability
of 5-FU and to target the colon for the effective treatment of colorectal cancer, the microbeads were
fabricated by emulsification crosslinking method using Box-Behnken design.

Objective:

To target the colon for effective treatment of colorectal cancer with enhanced oral bioavailability.

Methods:

The microparticulate drug delivery system was fabricated by using the emulsification crosslinking method by implementing a quality design approach with risk assessment followed by characterization such as FTIR, DSC, TGA, XRD, in vitro drug release, in vitro cytotoxicity study and in vivo
pharmacokinetic studies.

Results:

The patient-centric quality target product profile (QTPP) was set. QTPP inspired critical quality
attributes (CQAs) were searched out. The critical material attributes (CMAs) and critical process parameters (CPPs) influencing CQAs were distinguished. The seventeen formulations were fabricated employing Box Behnken Design, followed by optimization using numerical and graphical optimization techniques and the optimized microbeads were subjected to in vivo pharmacokinetic and in vitro cytotoxicity
studies using HT 29 cell lines. The results revealed that 5-FU-loaded microbeads exhibited significantly
more cytotoxic, and bioavailability was found to be nearly doubled as compared to pure drugs.

Conclusion:

5-FU-loaded microbeads can be developed and optimized successfully by using quality by
design approach and coating with eudragit S100, which can be targeted to the colon for the effective
treatment of colorectal cancer.
Automatic Recognition and Classification of Tomato Leaf Diseases Using Transfer Learning Model
Authors: Kumar Upadhyay Santosh , Kumar Avadhesh
Published: October 2023

Timely diagnosis of plant disease is important to get better crop yields.
Infected plants can cause significant financial losses to farmers by lowering crop
yields. It is extremely desirable to detect early signs and symptoms of plant diseases in
a nation like India, where agriculture supports the majority of the population. More
accurate and faster plant disease detection might assist in lowering the damage. With
tremendous improvements and advancements in deep learning, the effectiveness and
precision of plant disease detection and identification systems may be improved. The
goal of this study is to discover leaf illnesses found in tomato crops and reduce the
financial losses caused by the diseases. We have implemented transfer learning using a
pre-trained Squeeze Net Model to detect and classify tomato leaf diseases. Our model
can automatically detect 9 types of deadly diseases that are very common in tomato
crops. We have acquired 10 classes (one healthy leaf class and 9 diseased leaf classes)
consisting of 16,012 tomato leaf samples from a benchmarked Plant Village dataset to
train and validate the suggested method. On the public dataset, the class-wise
classification precision rate varies from 77.9% to 99.6%, and the overall classification
accuracy of the suggested model is observed as 93.1% which is a significant
enhancement in performance over previous tomato disease detection techniques.
Lista de Avaliadores 2022
Authors: Revista Ciências em Saúde
Published: October 2023

Os Editores da Revista Ciências em Saúde do Hospital de Clínicas de Itajubá, agradecem o primoroso e voluntário trabalho oferecido pelos profissionais listados abaixo, que serviram como pareceristas ad hoc durante o ano de 2022. O sistema de avaliação pelos pares (duplo-cega) depende da atuação isenta, competente e independente destes profissionais, de forma a manter os fundamentos das publicações científicas de qualidade.
Auditing Natural Language Processing for Gender Equality in Sub-Saharan African Healthcare Systems: Framework Development and Evaluation (Preprint)
Authors: Tresner-Kirsch David , Yinka-Banjo Chika , Akinyemi Mary , Ajayi Olasupo
Published: October 2023

BACKGROUND

Natural Language Processing models have wide and growing use in clinical and healthcare domains. Such applications enable scalable, efficient delivery of health information, but they are prone to equity challenges in their effectiveness across demographics and contexts. These models are only as good as the data they are trained on, the type of training, and parameters. Moreover, they are highly sensitive to latent demographic signals such as gender, age, nationality, and native language. Applications with biased components lead to inequitable outcomes. These accessibility challenges are more prevalent in rural regions of the world.

OBJECTIVE

This paper describes and evaluates a novel active learning approach for incrementally improving the accuracy of a Natural Language Processing (NLP), while optimizing for gender-equitable outcomes in healthcare systems. The approach employs an iterative cyclic model, incorporating data annotation using NLP, human auditing to improve the annotation accuracy especially for data with demographic segmentation, testing on new data (with intentional bias favoring underperforming demographics), and a loopback system for retraining the model and applying it on new data.

METHODS

We describe experimental integration of an audit tool and workflow with distinct NLP tasks in two separate contexts: i.) annotation of medical symptoms collected in Hausa and English languages based on responses to a research questionnaire about health access in Northern Nigeria; ii.) message intent classification in English and Swahili languages based on spontaneous user messages to a health guide chatbot in both Nigeria and Kenya.

RESULTS

Baseline results showed an equity gap in both precision (P) and recall (R): p=.725 and r=.676 for the over-reprsented class versus p=.669 and r=.651 for the under-represented class. Application of the active learning tool and workflow mitigated this gap after three increments of auditing and retraining (p=.721 and r=.760 for the under-represented class).

CONCLUSIONS

Our findings indicate that this gender-aware audit workflow is language agnostic and capable of mitigating demographic inequity while improving overall system accuracy.
SUNSHINE-eHealth: vital signs monitoring for early detection of clinical deterioration in high-risk oncological patients (Preprint)
Authors: Cani Massimiliano , Modesti Mikol , Ruinelli Lorenzo , Bünger Nicholas , Kopycinski Norbert , Lerch Erika , Ciliberti Esteban Andres , Zanon Massimiliano , Pascale Mariarosa , Tortola Luigi , Salfi Giuseppe , Liikkanen Sammeli , Gillessen Sommer Silke , Pereira Mestre Ricardo
Published: October 2023

BACKGROUND

Real-time remote monitoring and timely detection of clinical deterioration, especially for high-risk haematological and oncological outpatients, continues to be a challenge. Our pilot study, one of the few within this specific context, investigated between October 2021 and July 2022 a telemedicine- and wearable-based system to detect early changes in vital signs among high-risk oncological outpatients.

OBJECTIVE

Our primary objective was to assess the patients' perceived sense of safety at home during the remote monitoring period.

METHODS

28 outpatients from the Oncology Institute of Southern Switzerland (IOSI) were monitored for seven vital signs over a 7-day period using a wearable device (VitalPatch®). An online platform together with a 24/7 emergency call centre ensured the continuous remote monitoring. After the monitoring phase, participants completed a 14-item paper questionnaire.

RESULTS

The patient experience questionnaire was filled by 27 patients: the monitoring system increased the sense of safety in 96.3% (n=26) of patients and 88.9% (n=24) of them assessed the system as easy to use. Satisfaction with the remote medical assistance was “very high” or “high” in 85.0% (n=23) of patients and no patients dropped out. An event of a clinical interest occurred in 23.3% (n=7) patients, with 6.7% (n=2) also needing a hospitalization.

CONCLUSIONS

The technical arrangements seemed feasible to use for high-risk outpatients. Participants reported an increased sense of safety. These results support the future research and broader implementation of a wearable-based remote monitoring system for oncological outpatients in the future.
The Study of Numerical Simulation Based on Fuzzy PID Controller
Authors: Tu Zhihao , Wu Jiehong , Huang Xin , Wang Ruei-Yuan , Chen Ho-Sheng
Published: October 2023

This study aims to explore the application of an adaptive fuzzy PID (proportional integral differential) controller in system control. This controller combines the characteristics of fuzzy control and PID control and dynamically adjusts the parameters of the PID controller through a fuzzy inference mechanism to achieve adaptive adjustment of the system's dynamic characteristics. Firstly, by taking the control object of an industrial process as an example, the transfer function of the controlled object is determined to determine the initial parameters of the PID controller. Subsequently, a fuzzy inference module was introduced to adjust the proportional, integral, and differential coefficients of the PID controller through fuzzy rules based on the current state and error situation of the system. The simulation results show that, compared to traditional PID controllers, the adaptive fuzzy PID controller has achieved significant improvements in dynamic response speed and stability. Especially in the face of complex and rapidly changing control systems.
Plant-based products: Explore a way forward for mosquito’s management: A review
Authors: hanif Kanwal , Hussain Dilbar , Ranjha Mazhar Hussain , Ali Qurban
Published: October 2023

Mosquitoes (Diptera: Culicidae) pose a serious threat to humans worldwide, known to transmit various pathogens that cause infectious diseases and arboviruses, which are viral diseases such as chikungunya, dengue, Rift Valley fever, yellow fever, malaria, elephantiasis, Murray Valley encephalitis, Japanese encephalitis, Saint Louis encephalitis virus, West Nile virus, Eastern equine encephalomyelitis virus, Highlands J virus, Everglades virus, and crosse encephalitis virus. The emergence of widespread insecticide resistance and the potential adverse environmental problems associated with synthetic insecticides have highlighted the need for alternative methods to control the spread of mosquito populations, making it an important research priority. Safe and innovative tools, such as plant-based repellents, have recently been implemented to enhance mosquito management strategies. Plant-based repellents play a crucial role in the development of natural products as alternatives to chemical control methods. Plant extracts and essential oils, which are biodegradable, target-specific, eco-friendly, and have potent effects against mosquitoes, are reviewed in this article. These plant-based repellents offer promising potential for effective mosquito management, providing a safer and environmentally friendly approach to control mosquito populations and reduce the spread of mosquito-borne diseases. Properly formulated and used in combination with other integrated vector management strategies, plant-based repellents can contribute to sustainable and effective mosquito control efforts. Keywords: Essential oils, dengue, repellents, malaria mosquito, bio-products, management, biocontrol.