bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Cardiovascular Disease Risk Factors Among African Immigrants and African Americans: An Analysis of the 2010 to 2016 National Health Interview Surveys
Authors: Turkson‐Ocran Ruth‐Alma N. , Nmezi Nwakaego A. , Botchway Marian O. , Szanton Sarah L. , Golden Sherita Hill , Cooper Lisa A. , Commodore‐Mensah Yvonne
Published: February 2020

Background

Racial/ethnic minorities, especially non‐Hispanic blacks, in the United States are at higher risk of developing cardiovascular disease. However, less is known about the prevalence of
cardiovascular disease
risk factors among ethnic sub‐populations of blacks such as African immigrants residing in the United States. This study's objective was to compare the prevalence of
cardiovascular disease
risk factors among African immigrants and African Americans in the United States.

Methods and Results

We performed a cross‐sectional analysis of the 2010 to 2016 National Health Interview Surveys and included adults who were black and African‐born (African immigrants) and black and
US
‐born (African Americans). We compared the age‐standardized prevalence of hypertension, diabetes mellitus, overweight/obesity, hypercholesterolemia, physical inactivity, and current smoking by sex between African immigrants and African Americans using the 2010 census data as the standard. We included 29 094 participants (1345 African immigrants and 27 749 African Americans). In comparison with African Americans, African immigrants were more likely to be younger, educated, and employed but were less likely to be insured (
P
<0.05). African immigrants, regardless of sex, had lower age‐standardized hypertension (22% versus 32%), diabetes mellitus (7% versus 10%), overweight/obesity (61% versus 70%), high cholesterol (4% versus 5%), and current smoking (4% versus 19%) prevalence than African Americans.

Conclusions

The age‐standardized prevalence of
cardiovascular disease
risk factors was generally lower in African immigrants than African Americans, although both populations are highly heterogeneous. Data on blacks in the United States. should be disaggregated by ethnicity and country of origin to inform public health strategies to reduce health disparities.
The Cold War and Chinese Policy toward the Arab-Israeli Conflict, 1963–1975
Authors: She Gangzheng
Published: February 2020

This article explores the key issues in China's changing relations with the Arab countries and Israel from 1963 to 1975. Based on interviews, archival sources, and other materials, the article shows Beijing's attempts to justify its self-portrait as the only genuine patron of “national liberation movements” and to help foster the conditions for revolution in the Middle East by supporting a “people's war” against Israel. Although this radical design failed after the liquidation of Palestinian guerrillas in Jordan in the 1970s and the U.S.-Chinese rapprochement soon thereafter, the Sino-Soviet competition in the 1970s still gave enormous impetus to the visibility of the Palestine Liberation Organization in the international arena. The article discusses the roles of Chinese Communist leaders and diplomats in formulating Beijing's policy toward the Arab-Israeli conflict, which also served Mao Zedong's domestic mobilization before and during the Cultural Revolution. The article thus highlights a special connection across the international and domestic dimensions of China's Cold War experience.
A new species of Streblospio (Polychaeta: Spionidae) from the northern Adriatic Sea (Mediterranean Sea)
Authors: MUNARI CRISTINA , WOLF MARION A. , INFANTINI VANESSA , MORO ISABELLA , SFRISO ADRIANO , MISTRI MICHELE
Published: February 2020

The present study describes a new species of spionid polychaete, Streblospio eridani n. sp., from the Italian coasts of the Northern Adriatic Sea (Mediterranean Sea). This new spionid species was recorded from shallow lagoon and marine habitats: the soft bottoms of the Sacca di Goro (Po River Delta), on October 2017, and the Lido di Dante (Emilia Romagna), between 2016 and 2017. The re-assessment of spionid specimens from other lagoon systems (the Valli di Comacchio and the Valle di Gorino) led us to recognize the presence of this species in the northern Adriatic Sea since 2009. Streblospio eridani n. sp. had low occurrence and density at the marine site Lido di Dante and at the lagoon sites Valli di Comacchio and Valle di Gorino; whereas it reached the highest density of 21,213.3 ind. m-2 at the Sacca di Goro.  Morphologically this new species is characterized by dorsal (occipital) papilla on the first chaetiger, sabre chaetae and hooded hooks first appearing on chaetigers 7, hooks with 4-5 pairs of small secondary teeth, pygidium with ventral lappets, and brooding branchiate structures between chaetigers 13 and 28. In the phylogenetic reconstruction, based on the mitochondrial cytochrome c oxidase subunit I (COI) gene, the Adriatic taxon results clearly indicate that this is distinct from the other species of the genus and formed a well-supported clade with other Streblospio sp. specimens from India. Nucleotide divergences calculated between the Adriatic specimens and the other Streblospio species are higher than the intraspecific range reported for the genus and support the description of a new species. Morphological characters important for differentiation of the new species herein described from congeneric species are discussed and an updated key for Streblospio species is provided.
Rediscovery of the deep-water species Ypsilocucumis californiae Massin & Hendrickx, 2011 (Echinodermata; Holothuroidea; Ypsilothuriidae)
in western Mexico
Authors: LUNA-CRUZ ANA K. , HENDRICKX MICHEL E.
Published: February 2020

Four specimens of the sea cucumber Ypsilocucumis californiae Massin & Hendrickx, 2011 were obtained during sampling operations off western Mexico. These specimens permit identification of this species as a member of the deep-water holothuroid community off the west coast of the Baja California Peninsula. Previous records correspond to four locations (including the type locality) in the Gulf of California, where eight specimens were collected. SEM ossicles images are provided for the first time and new ecological data associated with the presence of this species are available: temperature, 5.34‒8.38 °C; dissolved oxygen, 0.15‒0.28 ml O2/l and salinity, 34.42‒34.51 ups. The specimens were present in a wide variety of sediments with an organic carbon content of 3.18‒5.20 mg C/g (5.47‒8.95 % organic matter). Density values indicated low abundance of this species in the area (2.63‒3.94 orgs/ha). Records presented here were in a depth range from 540 to 776 m, which corresponds to the lower limit of the Oxygen Minimum Zone of the eastern Pacific. Additional records are provided for the West Atlantic Ypsilocucumis asperrima (Théel, 1886) and a key to the species of Ypsilocucumis is provided.
A Novel Method for Interpolating Daily Station Rainfall Data Using a Stochastic Lattice Model
Authors: Khouider Boualem , Sabeerali C. T. , Ajayamohan R. S. , Praveen V. , Majda Andrew J. , Pai D. S. , Rajeevan M.
Published: February 2020

Rain gauge data are routinely recorded and used around the world. However, their sparsity and inhomogeneity make them inadequate for climate model calibration and many other climate change studies. Various algorithms and interpolation techniques have been developed over the years to obtain adequately distributed datasets. Objective interpolation methods such as inverse distance weighting (IDW) are the most widely used and have been employed to produce some of the most popular gridded daily rainfall datasets (e.g., India Meteorological Department gridded daily rainfall). Unfortunately, the skill of these techniques becomes very limited to nonexistent in areas located far away from existing recording stations. This is problematic as many areas of the world lack adequate rain gauge coverage throughout the recording history. Here, we introduce a new probabilistic interpolation method in an attempt to address this issue. The new algorithm employs a multitype particle interacting stochastic lattice model that assigns a binned rainfall value, from a given number of bins to each lattice site or grid cell, with a certain probability according to the rainfall amounts observed in neighboring sites and a background climatological rain rate distribution, drawn from the available data. Grid cells containing recording stations are not affected and are being used as “boundary” input conditions by the stochastic model. The new stochastic model is successfully tested and compared against two widely used gridded daily rainfall datasets over the Indian landmass for data from the summer monsoon seasons (June–September) for 1951–70.
PC 2D-COS: A Principal Component Base Approach to Two-Dimensional Correlation Spectroscopy
Authors: Hniopek Julian , Schmitt Michael , Popp Jürgen , Bocklitz Thomas
Published: February 2020

This paper introduces the newly developed principal component powered two-dimensional (2D) correlation spectroscopy (PC 2D-COS) as an alternative approach to 2D correlation spectroscopy taking advantage of a dimensionality reduction by principal component analysis. It is shown that PC 2D-COS is equivalent to traditional 2D correlation analysis while providing a significant advantage in terms of computational complexity and memory consumption. These features allow for an easy calculation of 2D correlation spectra even for data sets with very high spectral resolution or a parallel analysis of multiple data sets of 2D correlation spectra. Along with this reduction in complexity, PC 2D-COS offers a significant noise rejection property by limiting the set of principal components used for the 2D correlation calculation. As an example for the application of truncated PC 2D-COS a temperature-dependent Raman spectroscopic data set of a fullerene-anthracene adduct is examined. It is demonstrated that a large reduction in computational cost is possible without loss of relevant information, even for complex real world data sets.
Remaining in unhappy relationships: The roles of attachment anxiety and fear of change
Authors: George Tiffany , Hart Joshua , Rholes W. Steven
Published: February 2020

Romantic relationships are one of the most important sources of well-being. Unfortunately, many people who begin relationships with high hopes later find that they are unhappy but unwilling or unable to leave. Why do people remain in unsatisfactory relationships? The present research examined whether elevated fear of change in anxiously attached individuals is associated with greater commitment to unsatisfying relationships. We found that fear of change mediated the association between attachment anxiety and commitment to relationships, and that fear of being alone was a serial mediator for the anxiety to commitment association along with fear of change.
Validity of an enhanced EQ-5D-5L measure with an added cognitive dimension in patients with stroke
Authors: de Graaf JA , Kuijpers MMT , Visser-Meily JMA , Kappelle LJ , Post MWM
Published: February 2020

Objective:

The 5-level EuroQoL (EQ-5D-5L) is a patient-reported outcome measure frequently used in stroke research. However, it does not assess the cognitive problems many patients with stroke experience. The aim of this article is to compare the content validity, internal consistency and discriminative ability of the EQ-5D-5L with and without an additional cognitive domain (EQ-5D-5L+C), administered three months post-stroke.

Design:

Cross-sectional study.

Setting:

Six general hospitals in the Netherlands.

Subjects:

In all, 360 individuals with stroke three months after the event.

Interventions:

Not applicable.

Main measures:

The modified Rankin Scale and EQ-5D-5L+C were administered in telephone interviews three months post-stroke.

Results:

A total of 360 patients with stroke were included. Mean age was 68.8 years (standard deviation (SD) = 11.7), 143 (40%) were female, 334 (93%) had had an ischemic stroke, 165 (46%) had a National Institutes of Health Stroke Scale (NIHSS) score ⩽ 4 at presentation and the Barthel Index was 17.2 (SD = 4) four days post-stroke. Cognitive problems were reported by 199 (55%) patients three months post-stroke. Internal consistencies of the EQ-5D-5L and EQ-5D-5L+C were 0.75 and 0.77, respectively. Adding a cognitive domain resulted in a decrease of the ceiling effect from 22% to 14%. Both EQ-5D-5L and EQ-5D-5L+C showed good discriminative ability, but differences between patients with different modified Rankin Scale scores and with/without reported decrease in health and daily activities were slightly larger with the EQ-5D-5L+C compared to the EQ-5D-5L.

Conclusions:

The EQ-5D-5L+C, which includes a cognitive domain that is highly significant for stroke patients, showed increased content validity and good discriminative ability, without losing internal consistency.
Flexoelectric control of beams with atomic force microscope probe excitation
Authors: Zhang Xufang , Yu Wen , Fu Jiahong , Tzou Hornsen
Published: February 2020

Based on the converse flexoelectric effect, flexoelectric actuator is designed and used to control the dynamic displacement of cantilever beams. First, shell-type stress expression based on double-curvature shell induced by the converse flexoelectric effect is developed, which can be simplified to a flexoelectric-laminated cantilever beam by applying two Lamé parameters and beam radius of curvature. Then, the flexoelectric actuator is designed with a conductive atomic force microscope probe and a flexoelectric layer. An inhomogeneous electric field is generated when the external voltage is applied on the atomic force microscope probe and the flexoelectric layer, which leads to stress in the longitudinal direction of beam and control moment. With the flexoelectric-induced bending moment, displacement induced by the external force and flexoelectric actuator is derived. The displacement is related to many parameters, such as actuation voltage, atomic force microscope probe radius and flexoelectric layer thickness. Cases are studied to optimize the control effect with different parameters. Results show that vibration control effect is enhanced with a higher actuation voltage and a smaller atomic force microscope probe radius for each mode. Besides, the thicker flexoelectric layer enhances the control effect with a larger bending moment arm for each mode. Dynamic vibration is controlled effectively by converse flexoelectric effect.
Standardized Volume Dosing Protocol of 23.4% Hypertonic Saline for Pediatric Critical Care: Initial Experience
Authors: Cummings Brian M. , Fernandes Neil D. , Parker Lois F. , Murphy Sarah A. , Yager Phoebe H.
Published: February 2020

Background: Standardized volume dosing of 23.4% hypertonic saline (HTS) exists for adults, but the concentration, dosing and administration of HTS in pediatrics is variable. With emerging pediatric experience of 23.4% HTS, a standard volume dose approach may be helpful. Objective: To describe initial experience with a standardized 23.4% HTS weight-based volume dosing protocol of 10, 20, or 30 mL in the pediatric intensive care unit. Methods: Standard volume doses of 23.4% HTS were developed from weight dosing equivalents of 3% HTS. Pre and post sodium and intracranial pressure (ICP) measurements were compared with paired t-test or Wilcoxon rank-sum test. The site of administration and complications were noted. Results: A total of 16 pediatric patients received 37 doses of 23.4% HTS, with the smallest patient weighing 11 kg. For protocol compliance, 17 doses (46%) followed recommended dosing, 19 were less volume than recommended (51%), and 1 dose (3%) was more than recommended. Mean increase in sodium was 3.5 mEq/L (95% CI = 2-5 mEq/L); P < 0.0001. The median decrease in ICP was 10.5 mm Hg (interquartile range [IQR] 8.3-19.5) for a 37% (IQR 25%-64%) reduction. Most doses were administered through central venous access, although peripheral intravenous administrations occurred in 4 patients without complication. Conclusion and Relevance: Three standard-volume dose options of 23.4% HTS based on weight increases sodium and reduces ICP in pediatric patients. Standard-volume doses may simplify weight-based dosing, storage and administration for pediatric emergencies, although the optimum dose, and safety of 23.4% HTS in children remains unknown.
Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis
Authors: Frikha Rim
Published: February 2020

Objective

The methylenetetrahydrofolate reductase gene C677T polymorphism is closely related to the acute lymphoblastic leukemia. Several case–control studies have investigated this association; however, no conclusions could be drawn. A comprehensive updated meta-analysis is established to explain these contradictions and clarify the overall impact of this variant on the susceptibility to acute lymphoblastic leukemia.

Methods

Electronic searches were conducted to select published studies prior to June 2018. Pooled odds ratios and stratification analysis were performed under different genetic comparison models, age, and ethnicity.

Results

Totally, 66 case–control studies including 9619 acute lymphoblastic leukemia cases and 17,396 controls were selected. Our analyses showed that methylenetetrahydrofolate reductase C677T polymorphism was protective mainly in Asian and European countries, under all genetic models and regardless of age, but leukemogenic in mixed population.

Conclusion

Thus, C677T polymorphism may be a promising acute lymphoblastic leukemia biomarker, but they should be interpreted with caution considering other factors such as folic acid intake, gene–gene and gene–environment interactions.
Disassembling cattle and enskilling subjectivities: Butchering techniques and the emergence of new colonial subjects in Santiago de Guatemala
Authors: Delsol Nicolas
Published: February 2020

When they introduced cattle into Guatemala in the 16th century, Europeans also brought a whole new industry involving ranches, slaughterhouses, and new forms of labor. On the one hand, cattle producers had to treat the animals as intact living organisms requiring care and nurture to maintain and increase the herds. Those animals were grown by the ranchers for specific purposes. In the first place, colonial Mesoamerican cattle were raised to produce hides and leather for intercontinental trade with Spain. The regularized disassembling of the bovine bodies created these new products, but it also had some unintended consequences, namely the generation of new subject positions among the indigenous workers of these facilities. New forms of butchering techniques aimed at extracting animal parts were unlike the indigenous practices of animal hunting and exploitation, which aimed at preserving the physical integrity of the animals’ bodies. The newly introduced techniques that involved the compartmentalization of animal bodies also involved an increased compartmentalization of labor, accompanied by new body techniques and gestures. As the butchers and the tanners became enskilled, their bodies changed and so did their hexis. To operationalize these ideas, technological approaches combined with zooarchaeological (butchery marks), ethnographic, and historical evidence are used to investigate how humans and cattle mutually grew each other’s matter and subjectivities.
Shape shifting: Civilizational discourse and the analysis of cross-cultural interaction in the constitution of international society
Authors: O’Hagan Jacinta
Published: February 2020

The concept of civilization is intrinsic to the English School’s understanding of international society. At the same time, engagement with discourses of civilization has been an important site of contestation within the English School, with quite different narratives of the evolution, structures and dynamics of international society being articulated. I argue that deeper analysis of how different waves of English School scholars engage with discourses of civilization provides a valuable pathway for mapping the evolution of English School thought and its understanding of the structure and dynamics of international society. Discourse analysis, a method firmly embedded in interpretivist approaches, can provide us with a valuable approach to unravel the complexities of English School thinking about civilization. Applying discourse analysis to these bodies of work allows us to explore nodal points within English School debates, the layering of particular texts, and how scholars engage with strategies of juxtapositioning and counternarrative in order to reveal how subjects are positioned in hierarchies of authority and reveal previously subjugated voices in their interpretations of the constitution and evolution of international society.
Option of Using Peripherally Inserted Central Catheters in Elderly Patients With Dementia: An Observational Study
Authors: Nakano Yoshihisa , Kondo Takahisa , Murohara Toyoaki , Yamauchi Kazunobu
Published: February 2020

Background: Peripherally inserted central catheters (PICCs) facilitate the treatment of several diseases. Here, we assessed the clinical course of elderly patients with dementia using PICCs. Methods: This retrospective observational study was conducted at a single dementia treatment center. PICCs were used in elderly inpatients with dementia who required (a) intravenous therapy, supplemental parenteral nutrition, and dysphagia rehabilitation during acute illness; (b) end-of-life care; (c) total parenteral nutrition (TPN); or (d) an alternative to peripheral vascular (PV) access. Results: Fifty-nine patients were enrolled (83.5 ± 6.9 years): 61% were in the acute treatment group, and 17% were in the end-of-life care group. The median catheter lifespan was 42 (23–87.5) days. The incidence of catheter-related bloodstream infection was 0.22 per 1,000 PICC-days, and that of deep venous thrombosis was 0.66 per 1,000 PICC-days. Among the patients in acute treatment group, 19% resumed sufficient oral intake after the treatment using PICC, and 36% resumed oral intake of gelatin-like food. Among the patients in the end-of-life care group, 91% received intravenous fluids continuously until death by initially inserted PICC. Conclusion: In elderly patients with dementia, PICCs might be one of the options during the treatment of acute illness as well as for prolonged support during end-of-life care.
Transcriptomic analysis of the testicular fusion in Spodoptera litura
Authors: Chen Yaqing , Ou Jun , Liu Yucheng , Wu Qiong , Wen Liang , Zheng Sichun , Li Sheng , Feng Qili , Liu Lin
Published: February 2020

Background

Lepidoptera is one group of the largest plant-feeding insects andSpodoptera litura(Lepidoptera: Noctuidae) is one of the most serious agricultural pests in Asia countries. An interesting and unique phenomenon for gonad development of Lepidoptera is the testicular fusion. Two separated testes fused into a single one during the larva-to-pupa metamorphosis, which is believed to contribute to sperm production and the prevalence in field. To study the molecular mechanism of the testicular fusion, RNA sequencing (RNA-seq) experiments of the testes from 4-day-old sixth instar larvae (L6D4) (before fusion), 6-day-old sixth instar larvae (L6D6, prepupae) (on fusing) and 4-day-old pupae (P4D) (after fusion) ofS. liturawere performed.

Results

RNA-seq data of the testes showed that totally 12,339 transcripts were expressed at L6D4, L6D6 and P4D stages. A large number of differentially expressed genes (DEGs) were up-regulated from L6D4 to L6D6, and then more genes were down-regulated from L6D6 to P4D. The DEGs mainly belongs to the genes related to the 20E signal transduction pathway, transcription factors, chitin metabolism related enzymes, the families of cytoskeleton proteins, extracellular matrix (ECM) components, ECM-related protein, its receptor integrins and ECM-remodeling enzymes. The expression levels of these genes that were up-regulated significantly during the testicular fusion were verified by qRT-PCR. The matrix metalloproteinases (MMPs) were found to be the main enzymes related to the ECM degradation and contribute to the testicular fusion. The testis was not able to fuse if MMPs inhibitor GM6001 was injected into the 5th abdomen region at L6D6 early stage.

Conclusions

The transcriptome and DEGs analysis of the testes at L6D4, L6D6 and P4D stages provided genes expression information related to the testicular fusion inS. litura. These results indicated that cytoskeleton proteins, ECM-integrin interaction genes and ECM-related proteins were involved in cell migration, adhesion and fusion during the testicular fusion. The ECM degradation enzymes MMPs probably play a critical role in the fusion of testis.
Retrospective analysis of the immunogenic effects of intra-arterial locoregional therapies in hepatocellular carcinoma: a rationale for combining selective internal radiation therapy (SIRT) and immunotherapy
Authors: Craciun Ligia , de Wind Roland , Demetter Pieter , Lucidi Valerio , Bohlok Ali , Michiels Sébastien , Bouazza Fikri , Vouche Michael , Tancredi Ilario , Verset Gontran , Garaud Soizic , Naveaux Céline , Galdon Maria Gomez , Gallo Karen Willard , Hendlisz Alain , Derijckere Ivan Duran , Flamen Patrick , Larsimont Denis , Donckier Vincent
Published: February 2020

Background

Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing immunogenic cell death, such as transarterial chemoembolization (TACE) or selective internal radiation therapy (SIRT), have the potential to act synergistically with immunotherapy. For the development of new approaches combining locoregional treatments with immunotherapy, a better understanding of the respective effects of TACE and SIRT on recruitment and activation of immune cells in HCC is needed. To address this question, we compared intra-tumor immune infiltrates in resected HCC after preoperative treatment with TACE or SIRT.

Methods

Data fromr patients undergoing partial hepatectomy for HCC, without preoperative treatment (SURG,n = 32), after preoperative TACE (TACE,n = 16), or preoperative SIRT (n = 12) were analyzed. Clinicopathological factors, tumor-infiltrating lymphocytes (TILs), CD4+and CD8+T cells, and granzyme B (GZB) expression in resected HCC, and postoperative overall and progression-free survival were compared between the three groups.

Results

Clinicopathological and surgical characteristics were similar in the three groups. A significant increase in TILs, CD4+and CD8+T cells, and GZB expression was observed in resected HCC in SIRT as compared to TACE and SURG groups. No difference in immune infiltrates was observed between TACE and SURG patients. Within the SIRT group, the dose of irradiation affected the type of immune infiltrate. A significantly higher ratio of CD3+cells was observed in the peri-tumoral area in patients receiving < 100 Gy, whereas a higher ratio of intra-tumoral CD4+cells was observed in patients receiving > 100 Gy. Postoperative outcomes were similar in all groups. Irrespective of the preoperative treatment, the type and extent of immune infiltrates did not influence postoperative survival.

Conclusions

SIRT significantly promotes recruitment/activation of intra-tumor effector-type immune cells compared to TACE or no preoperative treatment. These results suggest that SIRT is a better candidate than TACE to be combined with immunotherapy for treatment of HCC. Evaluation of the optimal doses for SIRT for producing an immunogenic effect and the type of immunotherapy to be used require further evaluation in prospective studies.
Diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive, tissue cellularity marker to monitor cancer treatment response
Authors: Fliedner Frederikke Petrine , Engel Trine Bjørnbo , El-Ali Henrik H. , Hansen Anders Elias , Kjaer Andreas
Published: February 2020

Background

Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in cellular density of irradiated cancerous tissue will lead to an increase in quantitative apparent diffusion coefficient (ADC) values. DW-MRI can therefore serve as a non-invasive marker of cell death and apoptosis in response to treatment. In the present study, we aimed to investigate the applicability of DW-MRI in preclinical models to monitor radiation-induced treatment response. In addition, we compared DW-MRI with ex vivo measures of cell density, cell death and apoptosis.

Methods

DW-MRI was tested in two different syngeneic mouse models, a colorectal cancer (CT26) and a breast cancer (4 T1). ADC values were compared with quantitative determinations of apoptosis and cell death by flow cytometry. Furthermore, ADC-values were also compared to histological measurement of cell density on tumor sections.

Results

We found a significant correlation between ADC-values and apoptotic state in the CT26 model (P = 0.0031). A strong correlation between the two measurements of ADC-value and apoptotic state was found in both models, which were also present when comparing ADC-values to cell densities.

Conclusions

Our findings demonstrate that DW-MRI can be used for non-invasive monitoring of radiation-induced changes in cell state during cancer therapy. ADC values reflect ex vivo cell density and correlates well with apoptotic state, and can hereby be described as a marker for the cell state after therapy and used as a non-invasive response marker.
Smoking behaviours and attitudes towards campus-wide tobacco control policies among staff and students: a cross-sectional survey at the University of Birmingham
Authors: Bartington Suzanne E. , Wootton Ruth , Hawkins Philippa , Farley Amanda , Jones Laura L. , Haroon Shamil
Published: February 2020

Background

Tobacco control policies have potential to be an effective strategy for the reduction of smoking prevalence and secondhand smoke (SHS) exposure in tertiary educational settings worldwide. The aims of this study were to collect baseline data among staff and students, to measure smoking behaviours and attitudes towards introduction of campus-wide tobacco control policies within a UK higher education setting.

Methods

Cross-sectional study using data collected by web-based questionnaire administered to employed staff and enrolled students (undergraduate/postgraduate) at the University of Birmingham from May 2016 to April 2017. Information was obtained regarding demographic characteristics, tobacco usage patterns and attitudes towards a revised campus tobacco control policy using a 21-item survey tool. Logistic regression analyses were used to explore associations between participant characteristics and support for smoke-free or tobacco-free campus policy options, evaluated by crude and adjusted Odds Radios (OR) after controlling for confounding factors (significance level:P < 0.05).

Results

A total of 934 survey responses were received, of whom 780 participants provided complete information on staff or student status and were included in the present analysis. Current smoking prevalence was 14% (N = 109; 95% confidence interval (CI) 11.6–16.6). Overall, 66.3% (95% CI: 62.9–69.7) of participants supported a smoke-free campus; 68.5% (95% CI: 65.2–71.8) endorsed restrictions for tobacco sales and just under half of respondents (47.3%; 95% CI: 43.8–50.9) supported a ban for electronic cigarettes/vaping device use on campus. Smoking status was an independent predictor of support for tobacco control, with the lowest level of support for a smoke-free campus among daily (adjusted OR 0.02; 95% CI: 0.01–0.05) and intermittent smokers (adjusted OR 0.06; 95% CI: 0.02–0.16).

Conclusions

Overall, the majority of staff and students participating in this baseline survey supported implementation of a smoke-free or comprehensive tobacco-free campus policy. These findings may inform the development and future implementation of a revised tobacco control policy at the university which reflects contemporary attitudes and considers a broad range of implementation issues, including behaviour change and environmental adaptations.
Correction to: Study protocol the Continuing Care Project: a randomised controlled trial of a continuing care telephone intervention following residential substance dependence treatment
Authors: Kelly Peter , Deane Frank , Baker Amanda , Byrne Gerard , Degan Tayla , Osborne Briony , Townsend Camilla , McKay James , Robinson Laura , Oldmeadow Christopher , Lawson Kenny , Searles Andrew , Lunn Joanne
Published: February 2020

It was highlighted that in the original article [1] author Amanda Baker was erroneously omitted from the authorship during the copy editing stage.
Suicide by pesticide poisoning in India: a review of pesticide regulations and their impact on suicide trends
Authors: Bonvoisin Toby , Utyasheva Leah , Knipe Duleeka , Gunnell David , Eddleston Michael
Published: February 2020

Background

Pesticide self-poisoning is a common means of suicide in India. Banning highly hazardous pesticides from agricultural use has been successful in reducing total suicide numbers in several South Asian countries without affecting agricultural output. Here, we describe national and state-level regulation of highly hazardous pesticides and explore how they might relate to suicide rates across India.

Methods

Information on pesticide regulation was collated from agriculture departments of the central government and all 29 state governments (excluding union territories). National and state-level data on suicides from 1995 to 2015 were obtained from the National Crime Records Bureau (NCRB). We used joinpoint analysis and negative binomial regression to investigate the trends in suicide rates nationally and in Kerala, in view of the robust measures Kerala has taken to restrict a number of HHPs, to identify any effect on suicides.

Results

As of October 2019, 318 pesticides were registered for use in India, of which 18 were extremely (Class Ia) or highly (Class Ib) hazardous according to World Health Organization toxicity criteria. Despite many highly hazardous pesticides still being available, several bans have been implemented during the period studied. In our quantitative analyses we focused on the permanent bans in Kerala in 2005 (of endosulfan) and 2011 (of 14 other pesticides); and nationally in 2011 (of endosulfan). NCRB data indicate that pesticides were used in 441,918 reported suicides in India from 1995 to 2015, 90.3% of which occurred in 11 of the 29 states. There was statistical evidence of lower than expected rates of pesticide suicides (rate ratio [RR] 0.52, 95% CI 0.49–0.54) and total suicides nationally by 2014 (0.90, 0.87–0.93) after the 2011 endosulfan ban. In Kerala, there was a lower than expected rate of pesticide suicides (0.45, 0.42–0.49), but no change to the already decreasing trend in total suicides (1.02, 1.00–1.05) after the 2011 ban of 14 pesticides. The 2005 ban on endosulfan showed a similar effect – lower than expected pesticide suicides (0.79, 0.64–0.99), but no change to the decreasing trend of total suicides (0.97, 0.93–1.02) in 2010. There was no evidence of a decline in agricultural outputs following the bans.

Conclusion

Highly hazardous pesticides continue to be used in India and pesticide suicide remains a serious public health problem. However, some pesticide bans do appear to have impacted previous trends in the rates of both pesticide suicides and all suicides. Comprehensive national bans of highly hazardous pesticides could lead to a reduction in suicides across India, in addition to reduced occupational poisoning, with minimal effects on agricultural yield.
Health workers’ perceptions and challenges in implementing meningococcal serogroup a conjugate vaccine in the routine childhood immunization schedule in Burkina Faso
Authors: Nkwenkeu Sylvain F. , Jalloh Mohamed F. , Walldorf Jenny A. , Zoma Robert L. , Tarbangdo Felix , Fall Soukeynatou , Hien Sansan , Combassere Roland , Ky Cesaire , Kambou Ludovic , Diallo Alpha Oumar , Krishnaswamy Akshaya , Aké Flavien H. , Hatcher Cynthia , Patel Jaymin C. , Medah Isaïe , Novak Ryan T. , Hyde Terri B. , Soeters Heidi M. , Mirza Imran
Published: February 2020

Background

Meningococcal serogroup A conjugate vaccine (MACV) was introduced in 2017 into the routine childhood immunization schedule (at 15–18 months of age) in Burkina Faso to help reduce meningococcal meningitis burden. MACV was scheduled to be co-administered with the second dose of measles-containing vaccine (MCV2), a vaccine already in the national schedule. One year following the introduction of MACV, an assessment was conducted to qualitatively examine health workers’ perceptions of MACV introduction, identify barriers to uptake, and explore opportunities to improve coverage.

Methods

Twelve in-depth interviews were conducted with different cadres of health workers in four purposively selected districts in Burkina Faso. Districts were selected to include urban and rural areas as well as high and low MCV2 coverage areas. Respondents included health workers at the following levels: regional health managers (n = 4), district health managers (n = 4), and frontline healthcare providers (n = 4). All interviews were recorded, transcribed, and thematically analyzed using qualitative content analysis.

Results

Four themes emerged around supply and health systems barriers, demand-related barriers, specific challenges related to MACV and MCV2 co-administration, and motivations and efforts to improve vaccination coverage. Supply and health systems barriers included aging cold chain equipment, staff shortages, overworked and poorly trained staff, insufficient supplies and financial resources, and challenges with implementing community outreach activities. Health workers largely viewed MACV introduction as a source of motivation for caregivers to bring their children for the 15- to 18-month visit. However, they also pointed to demand barriers, including cultural practices that sometimes discourage vaccination, misconceptions about vaccines, and religious beliefs. Challenges in co-administering MACV and MCV2 were mainly related to reluctance among health workers to open multi-dose vials unless enough children were present to avoid wastage.

Conclusions

To improve effective administration of vaccines in the second-year of life, adequate operational and programmatic planning, training, communication, and monitoring are necessary. Moreover, clear policy communication is needed to help ensure that health workers do not refrain from opening multi-dose vials for small numbers of children.
Impact of a one-year school-based teacher-implemented nutrition and physical activity intervention: main findings and future recommendations
Authors: Habib-Mourad Carla , Ghandour Lilian A. , Maliha Carla , Awada Nancy , Dagher Michèle , Hwalla Nahla
Published: February 2020

Background

The aim of the current study is to describe the effectiveness of a school-based intervention when delivered by a non-nutrition specialist (trained schoolteachers) as compared to an expert in nutrition.

Methods

Two trials of the same school-based intervention using the same intervention package were delivered, one by nutritionists and another by trained schoolteachers. The intervention focused mainly on dietary behaviours, as well as physical activity. In both trials, purposively selected schools were randomized to intervention or control groups; students (aged 9–11 years) in both groups were compared at post-test on knowledge and self-efficacy scores, as well as dietary and physical activity behaviours, controlling for their baseline status on the various measures. All analyses accounted for clustering at the school level.

Results

In both trials, a statistically significantly greater improvement was observed for both the knowledge and self-efficacy scores in intervention vs. school students. When the programme was delivered by trained schoolteachers, frequency of breakfast intake was increased, crisps consumption was reduced, but no change in fruit and vegetable consumption was observed (latter increased when delivered by nutrition professionals only). Physical activity did not improve in both trials.

Conclusion

Trained schoolteachers can have a positive impact on students’ dietary behaviours with the appropriate training to ensure they are equipped with the right information, skills, and resources to deliver the programme with the highest fidelity.

Trial registration

ClinicalTrial.gov Identifier: NCT03040271. Retrospectively registered on 2 February 2017.
Right single lung transplantation using an inverted left donor lung: interposition of pericardial conduit for pulmonary venous anastomosis - a case report
Authors: Yamamoto Haruchika , Miyoshi Kentaroh , Otani Shinji , Kurosaki Takeshi , Sugimoto Seiichiro , Yamane Masaomi , Toyooka Shinichi , Kobayashi Motomu , Oto Takahiro
Published: February 2020

Background

Lung transplantation (LTx) is still limited by the shortage of suitable donor lungs. Developing flexible surgical procedures can help to increase the chances of LTx by unfolding recipient-to-donor matching options based on the pre-existing organ allocation concept. We report a case in which a successful left-to-right inverted LTx was completed using the interposition of a pericardial conduit for pulmonary venous anastomosis.

Case presentation

A left lung graft was offered to a 59-year-old male who had idiopathic pulmonary fibrosis with predominant damage in the right lung. He had been prescribed bed rest with constant oxygen inhalation through an oxymizer pendant and had been on the waiting list for 20 months. Considering the condition of the patient (LAS 34.3) and the scarcity of domestic organ offers, the patient was highly likely to be incapable of tolerating any additional waiting time for another donor organ if he was unable to accept the presently reported offer of a left lung. Eventually, we decided to transplant the left donor lung into the right thorax of the recipient. Because of the anterior-posterior position gap of the hilar structures, the cuff lengths of the pulmonary veins had to be adjusted. The patient did not develop any anastomotic complications after the transplantation.

Conclusions

A left-to-right inverted LTx is technically feasible using an autologous pericardial conduit for pulmonary venous anastomosis in selected cases. This technique provides the potential benefit of resolving challenging situations in which surgeons must deal with a patient’s urgency and the logistical limitations of organ allocation.
Cardiac valvular abnormalities associated with use and cumulative exposure of cabergoline for hyperprolactinemia: the CATCH study
Authors: Budayr Amer , Tan Thida C. , Lo Joan C. , Zaroff Jonathan G. , Tabada Grace H. , Yang Jingrong , Go Alan S.
Published: February 2020

Background

Whether lower dose cabergoline therapy for hyperprolactinemia increases risk of valvular dysfunction remains controversial. We examined valvular abnormalities among asymptomatic adults with hyperprolactinemia treated with dopamine agonists.

Methods

This cross-sectional study was conducted among adults receiving cabergoline or bromocriptine for > 12 months for hyperprolactinemia and had no cardiac-related symptoms. Cardiac valve morphology and function were assessed from transthoracic echocardiograms at the study visit (except for two participants) with evaluation performed blinded to type and duration of dopamine agonist received.

Results

Among 174 participants (mean age 49 ± 13 years, 63% women) without known structural heart disease before starting therapy, 62 received only cabergoline, 63 received only bromocriptine, and 49 received both. Median cabergoline use was 2.8 years in cabergoline only users and 3.2 years for those exposed to both cabergoline and bromocriptine; median bromocriptine use was 5.5 years in bromocriptine only users and 1.1 years for those exposed to both cabergoline and bromocriptine. Compared with bromocriptine only users (17.5%), regurgitation of ≥1 valve was more common for cabergoline only (37.1%, P = 0.02) but not for combined exposure (26.5%, P = 0.26). Compared with bromocriptine only exposure (1.6%), regurgitation of ≥2 valves was more common for cabergoline only (11.3%, P = 0.03) and combined exposure (12.2%, P = 0.04). Cabergoline only users had higher age-sex-adjusted odds for ≥1 valve with grade 2+ regurgitation compared to bromocriptine only users (adjusted odds ratio [aOR] 3.2, 95% confidence interval [CI]:1.3–7.5, P = 0.008), but the association for combined exposure to cabergoline and bromocriptine was not significant (aOR 1.7, 95%CI:0.7–4.3, P = 0.26). Compared to bromocriptine only, age-sex-adjusted odds of ≥2 valves with grade 2+ regurgitation were higher for both cabergoline only (aOR 8.4, 95% CI:1.0–72.2, P = 0.05) and combined exposure (aOR 8.8, 95% CI:1.0–75.8, P = 0.05). Cumulative cabergoline exposure > 115 mg was associated with a higher age-sex adjusted odds of ≥2 valves with grade 2+ regurgitation (aOR 9.6, 95%CI:1.1–81.3, P = 0.04) compared to bromocriptine only.

Conclusions

Among community-based adults treated for hyperprolactinemia, cabergoline use and greater cumulative cabergoline exposure were associated with a higher prevalence of primarily mild valvular regurgitation compared with bromocriptine. Research is needed to clarify which patients treated with dopamine agonists may benefit from echocardiographic screening and surveillance.
Clinical and biochemical factors to predict biochemical adrenal insufficiency in hospitalized patients with indeterminate cortisol levels: a retrospective study
Authors: Manosroi Worapaka , Kosachunhanan Natapong , Atthakomol Pichitchai
Published: February 2020

Background

Adrenal insufficiency (AI) in hospitalized patients is a fatal condition if left undiagnosed. Most patients may require an adrenocorticotropic hormone (ACTH) stimulation test to facilitate AI diagnosis. We aim to identify simple biochemical and clinical factors and derive a predictive model to help identify hospitalized patients with biochemical AI who have indeterminate 0800 h serum cortisol levels.

Methods

A seven-year retrospective study was performed in a tertiary care medical center. We identified 128 inpatients who had undergone low-dose or high-dose ACTH stimulation tests. The association between biochemical AI and other factors was evaluated using a logistic regression model clustering by ACTH dose. Stepwise regression analysis was used to demonstrate the predictive model. Diagnostic performance was evaluated using ROC analysis.

Results

Of the 128 patients, 28.1% had biochemical AI. The factors associated with biochemical AI were serum random cortisol < 10 μg/dL (OR = 8.69, p < 0.001), cholesterol < 150 mg/dL (OR = 2.64, p = 0.003), sodium < 140 mmol/L (OR = 1.73, p = 0.004)). Among clinical factors, cirrhosis (OR = 9.05, p < 0.001), Cushingoid appearance in those with exogenous steroid use (OR = 8.56, p < 0.001), and chronic kidney disease (OR = 2.21, p < 0.001) were significantly linked to biochemical AI. The AUC-ROC of the final model incorporating all factors was 83%.

Conclusions

These easy-to-perform biochemical tests and easy-to-assess clinical factors could help predict biochemical AI in hospitalized patients with high accuracy. The physician should therefore have a high index of suspicion to perform dynamic tests for AI diagnosis in those who meet the proposed model criteria.