MODULATORY EFFECT OF HARMINE ON SPATIAL MEMORY, FERTILITY VIA MAO INHIBITION, PREVENTING ANEMIA AND ANTI-NOCICEPTION UPON FOOTSHOCK STRESS AT THREE STAGES OF PREGNANT RATS
Authors: Benatoui Rima , Bairi Abdelmadjid , Tahraoui Abdelkrim 
Published: November 2021

Aim and objective: Stress has overwhelmed the world, mortality due to stress is continually increasing, and pregnancy has known by its physiological modulation. This article has a clear explanation about the effect of the ß-carboline alkaloid harmine containing in the plant of Peganum harmala, it makes a huge debate in many countries as Iran, Brazil, Algeria, China, Australia about the main component that exerted abortion and until now there is no work resolved the matter.
Methods: In this study, we planned our experience, so that each sub-group treated with harmine, stressed with footshock or received the both, according to their pregnancy stages.
Results: Footshock stress as expected with its maximum intensity could be tolerated by the fetuses so could keep the rats pregnant along the main stage, damaged to several physiological parameters, but it makes a good pairing with harmine.
Conclusion: Harmine has enhanced the cognition during pregnancy, and exerted its anxiolytic effect too. Its decreasing effect of food consumption and enhancement of implantation was the main reason to confirm its raising estrogen levels from previous works, raising thrombocytes due to its enhancement of serotonin via its effect of monoamine-oxydase inhibitor MAO I. In other hand, footshock stress even its expected placentation defect but it seemed having an ameliorating effect on immune function during pregnancy.
                 
Peer Review History:
Received: 8 September 2021; Revised: 11 October; Accepted: 26 October, Available online: 15 November 2021
Academic Editor:  Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com 
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Received file:                Reviewer's Comments:
Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com
Dr. Vanina Doris Edo’o, University of Yaounde I, Yaounde, Cameroun, vanina_edoo@yahoo.com
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