bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental and climatic factors affecting winter hypoxia in a freshwater lake: evidence for a hypoxia refuge and for re-oxygenation prior to spring ice loss
Authors: Davis Michael N. , McMahon Thomas E. , Cutting Kyle A. , Jaeger Matthew E.
Published: September 2020

Low dissolved oxygen, or hypoxia, is a common phenomenon in ice-covered lakes in winter. We measured dissolved oxygen (DO) before, during, and after ice-over to characterize the timing, severity, and spatial variability of winter hypoxia in Upper Red Rock Lake, Montana, home to one of the last remaining lacustrine populations of endemic Montana Arctic Grayling (Thymallus arcticus). Unlike most previous investigations of winterkill-prone lakes, we observed considerable horizontal spatial variability in DO, a non-linear winter oxygen depletion rate, and lake-wide re-oxygenation 2–4 weeks prior to spring ice loss. Parts of the upper 1 m of the lake and near stream mouths remained well-oxygenated even during late winter. DO levels were strongly associated with maximum daily air temperature. Our analysis of a 28-year weather record revealed large interannual variability in risk of winter hypoxia, with a slight declining trend in winter severity (number of days with maximum air temperatures ≤ 0°C) in Upper Red Rock Lake. The approach we used in our study provides a useful framework for quantifying and mapping the seasonal dynamics of the extent and severity of winter hypoxia, and for identifying critical winter habitats.
Time-temperature behavior of carbon/epoxy laminates under creep loading
Authors: Ornaghi Heitor L. , Almeida José Humberto S. , Monticeli Francisco M. , Neves Roberta M. , Cioffi Maria Odila H.
Published: September 2020

The time-temperature creep behavior of advanced composite laminates is herein determined through a comprehensive set of experiments and analytical modeling. A complete structure versus property relationship is determined through a wide range of temperature and applied stress levels at the three states of the composite: glassy, glass transition, and rubbery regions. Weibull, Eyring, Burger, and Findley models are employed to predict the experimental data and to better elucidate the material behavior. Experimental creep tests are carried out under ten min and two days aiming at calibrating fitting parameters, which are essential to validate short-term creep tests. The Weibull and Eyring models are more suitable for determining the time-temperature superposition (TTS) creep response in comparison to the Burger and Findley models.
Horsemint as a potential raw material for the food industry: survey on the chemistry of a less studied mint species
Authors: Patonay Katalin , Németh-Zámboriné Éva
Published: September 2020

Horsemint (Mentha longifolia L), is wild-growing species, widespread in Eurasia and Africa. The review focuses on its potential utilization as a preservative and flavoring in the food industry based on the polyphenolic and terpenoid composition. Several phenolic antioxidants were detected in horsemint, among which rosmarinic acid may have a key role. Nineteen other acids, and fifty-five flavonoids (six which are de novo) were also identified. The antiradical efficacy in horsemint extract has not yet been adequately justified. Similarly, systematic screening of the flavonoid composition of the species is lacking. Horsemint essential oils possesses an outstandingly wide variability in composition which may serve as basis of special flavoring or antimicrobial agents. The efficacy of horsemint volatiles have been demonstrated against more than twenty microbes. As current literature of horsemint lacks comparable results, the present review provides the broadest and therefore, a critical overview, on its most important secondary compounds and the factors influencing their accumulation.
Opportunistically collected data from aerial surveys reveal spatio-temporal distribution patterns of marine debris in German waters
Authors: Unger Bianca , Herr Helena , Viquerat Sacha , Gilles Anita , Burkhardt-Holm Patricia , Siebert Ursula
Published: September 2020

Marine debris is known for its ubiquitousness and harmful effects on marine life. This study is the first analysis to provide information on the distribution of floating marine debris in German waters using aerial survey data collected between 2002 and 2016. During regular harbour porpoise monitoring flights, 191,167 km were covered and 26,512 floating debris items recorded (average encounter rate 0.1387 items/km). Debris was encountered more often in the North Sea than in the Baltic Sea (0.16 items/km; 0.08 items/km). The average encounter rate was higher in offshore waters than in coastal areas. Overlaps of marine debris distribution with ‘Special Areas of Conservation’ are a particular reason for concern. Moreover, the spring months (March–May) were identified to be the time of the year with the highest average encounter rates for marine debris. Fishing-related debris was shown to contribute up to 25% of the total number of all observed items. This study shows that opportunistically collected data on marine debris from aerial surveys are valuable for identifying distribution patterns of floating debris without additional survey effort and costs. These data can be used as baseline information to inform management schemes such as the Marine Strategy Framework Directive.
An investigation into the anthropogenic nexus among consumption of energy, tourism, and economic growth: do economic policy uncertainties matter?
Authors: Adedoyin Festus Fatai , Nathaniel Solomon , Adeleye Ngozi
Published: September 2020

Global warming has been a pressing issue for the past decade as various economic activities have been flagged and are expected to reduce emissions. While previous studies have examined the energy consumption-emissions-economic growth nexus in significant detail, attention is yet to be given to the role of economic policy uncertainties and human activities such as tourism in a carbon function. Thus, this study aims to investigate the long-run relationship between energy consumption, tourists’ arrivals, economic policy uncertainty, and ecological footprint in the top ten earners from international tourism over the period 1995 to 2015. The fully modified ordinary least square and dynamic ordinary least square estimation techniques and the Dumitrescu and Hurlin causality tests were used in the study. Empirical results suggest that economic policy uncertainties in addition to tourism and energy consumption are drivers of environmental degradation. However, the contribution of energy consumption to ecological footprint is significantly moderated by economic policy uncertainties such that a 1% increase in the latter reduces environmental damage by 0.71%. This study suggests that policy uncertainties matter a great deal for energy and environmental policies. Also, green economic growth is possible if the proper implementation of environmental protection policies can restrict the harmful impact of economic activities on the quality of the environment. Based on the empirical findings, vital energy policy recommendations are suggested.
On the existence of the Hutchinson measure for generalized iterated function systems
Authors: Strobin Filip
Published: September 2020

We prove that each generalized (in the sense of Miculescu and Mihail) IFS consisting of contractive maps generates the unique generalized Hutchinson measure. This result extends the earlier result due to Miculescu in which the assertion is proved under certain additional contractive assumptions.
Is the Social Desirability Effect in Human–Robot Interaction overestimated? A Conceptual Replication Study Indicates Less Robust Effects
Authors: Leichtmann Benedikt , Nitsch Verena
Published: September 2020

The “Computers are social actors” (CASA) assumption (Nass and Moon in J Soc Issues 56:81–103, 2000.https://doi.org/10.1111/0022-4537.00153) states that humans apply social norms and expectations to technical devices. One such norm is to distort one’s own response in a socially desirable direction during interviews. However, findings for such an effect are mixed in the literature. Therefore, a new study on the effect of social desirability bias in human–robot evaluation was conducted, aiming for a conceptual replication of previous findings. In a between-subject laboratory experiment,$$N = 107$$N=107participants had to evaluate the robot and the interaction quality after a short conversation in three different groups: In one group, the evaluation was conducted using (1) the same robot of the former interaction, (2) a different robot, (3) a tablet computer. According to the CASA assumption, it was expected, that evaluations on likability and quality of interaction, are higher in the condition with the same robot conducting the evaluation, compared to a different robot or a tablet computer because robots are treated as social actors and hence humans distort ratings in a socially desirable direction. Based on previous findings, we expected robots to evoke higher anthropomorphism and feelings of social presence compared to the tablet computer as potential explanation. However, the data did not support the hypotheses. Low sample size, low statistical power, lack of measurement validation and other problems that could lead to an overestimation of effect sizes—in this study and the literature in general—are discussed in light of the replicability crisis.
Unsupervised approach towards analysing the public transport bunching swings formation phenomenon
Authors: Degeler Viktoriya , Heydenrijk-Ottens Léonie , Luo Ding , van Oort Niels , van Lint Hans
Published: September 2020

We perform an analysis of public transport data from The Hague, the Netherlands, combined from three sources: static network information, automatic vehicles location and automated fare collection data. We highlight the effect of bunching swings, and show that this phenomenon can be extracted using unsupervised machine learning techniques, namely clustering. We also show the correlation between bunching rate and passenger load, and bunching probability patterns for working days and weekends. We present the approach for extracting isolated bunching swings formations (BSF) and show different cases of BSFs, some of which can persist for a considerable time. We applied our approach to the tram line 1 of The Hague, and computed and presented four different patterns of BSFs, which we name “high passenger load”, “whole route”, “evening, end of route”, “long duration”. We analyse each bunching swings formation type in detail.
Investigation of obsolete diversity of rye (Secale cereale L.) using multiplexed SSR fingerprinting and evaluation of agronomic traits
Authors: Targonska-Karasek Malgorzata , Boczkowska Maja , Podyma Wieslaw , Pasnik Małgorzata , Niedzielski Maciej , Rucinska Anna , Nowak-Zyczynska Zuzanna , Rakoczy-Trojanowska Monika
Published: September 2020

Common rye (Secale cereale L.) is one of the most important cereals in Europe. Nevertheless, its germplasm collections are among the least numerous compared with cereals. There are only about 27,000 Secale accessions in 70 gene banks around the world. Despite extensive research on the molecular characterization of genetic resources, only a fraction of this collection has been described. The main objective of the presented study was to perform genotypic and phenotypic characterization of an obsolete gene pool represented by 100 accessions originated from 28 countries around the world and preserved in the gene bank of the Polish Academy of Sciences Botanical Garden – Center for Biological Diversity Conservation in Powsin. Genetic analysis using simple sequence repeat markers showed that the obsolete gene pool is relatively large. This indicates that different sources of variability were used in breeding programs. However, the genetic variation is in no way related to the place of origin. Despite the great differences in the genetic make-up, the collection showed a broadly common phenotype. This could result in a low level of interest among breeders in the stored germplasm, undervalued as a source of important but not easily observable traits, e.g., high disease resistance, which was found in some accessions.
Addressing graduate capability through action research: a cross-disciplinary perspective in a New Zealand context
Authors: Zhang Qilong
Published: September 2020

The concept “graduate capability” has been created to respond to the trend that tertiary education graduates routinely encounter uncertainty and complexity. Adopting a multiple-site action research design, this study explored ways to address graduate capability across five disciplines in a New Zealand vocational education institution. Participants were 215 students and 21 teaching staff. Data collection included interviews, team meetings, and a variety of pedagogical documentation. Ethnographic content analysis was used for data analysis which generated five discipline-specific approaches to graduate capability intervention. Each approach included five dimensions: selection of focus capability items (FCIs) for intervention, composition of FCIs, strategies to address FCIs, impact of the intervention, and relationship between the intervention and the academic programme. This study not only helps the sampled programmes address graduate capability in an intentional and systematic way, but also offers an operational framework for designing capability intervention programmes in similar settings.
A Systematic Review of Bullying and Victimization Among Adolescents in India
Authors: Thakkar Niharika , van Geel Mitch , Vedder Paul
Published: September 2020

This study provides a systematic review of literature from India on traditional bullying and victimization among school-going adolescents. A search of bibliographic electronic databases PsycINFO, MEDLINE, ERIC, Web of Science, and PubMed was performed in May 2020. Thirty-seven studies were included in the review. For each study included, the following specifics were examined: (a) methodological characteristics, (b) prevalence estimates of bullying behavior, (c) forms of bullying, (d) risk factors, and (e) consequences of bullying. It was found that bullying happens in India, and some risk factors for bullying and victimization in India are typical to the Indian context. In addition, bullying in India is associated with adverse consequences for both the aggressor and the victim. Many studies on bullying from India should be interpreted cautiously because of problems with data collection processes, instrumentation, and presentation of the findings. Cross-cultural comparisons for prevalence estimates, and longitudinal studies to examine the direction of possible influence between bullying and its correlates need to be conducted, to cater to the large adolescent population of India.
Changes in positive and negative peer influences and depressive symptoms from adolescence to young adulthood
Authors: Homel Jacqueline , Thompson Kara , Leadbeater Bonnie
Published: September 2020

Introduction

Peers are believed to continue as prominent sources of influence for young adults. However, having peers who use alcohol and drugs is associated with depressive symptoms in young adults and research on the effects of having peers who model positive activities beyond adolescence is scarce.

Method

In this 10‐year study of 644 Canadian youth (52% female), we used multilevel modeling to examine the effects of within‐person and between‐person differences in the interplay of peer behaviours and changes in depressive symptoms between ages 14 and 25. Data were collected via face‐to‐face interviews and surveys for private topics.

Results

Youth with close friends who used drugs and alcohol consistently reported more depressive symptoms at each age, whereas having friends who engaged in positive activities was associated with fewer depressive symptoms, especially during adolescence. Moreover, at times when youth had more substance‐using peers than usual (within person variation), they also reported more symptoms.

Conclusions

Substance‐using peer contexts convey both short‐ and long‐term risks for depressive symptoms. However, the protective effects of having peers who are engaged in positive activities, while generally protective, may be reduced in young adulthood. It is possible that older youth withdraw from peers and activities as their depression worsens, and prosocial activities become less supervised by parents, more optional, and more expensive.
How others drive our sense of understanding of policies
Authors: RABB NATHANIEL , HAN JOHN J. , SLOMAN STEVEN A.
Published: September 2020

Five experiments are reported to compare models of attitude formation about hot-button policy issues like climate change. In broad strokes, the deficit model states that incorrect opinions are a result of a lack of information, while the cultural cognition model states that opinions are formed to maximize congruence with the group that one affiliates with. The community of knowledge hypothesis takes an integrative position. It states that opinions are based on perceived knowledge, but that perceptions are partly determined by the knowledge that sits in the heads of others in the community. We use the fact that people's sense of understanding is affected by knowledge of others’ understanding to arbitrate among these views in the domain of public policy. In all experiments (N = 1767), we find that the contagious sense of understanding is nonpartisan and robust to experimental manipulations intended to eliminate it. While ideology clearly affects people's attitudes, sense of understanding does as well, but level of actual knowledge does not. And the extent to which people overestimate their own knowledge partly determines the extremity of their position. The pattern of results is most consistent with the community of knowledge hypothesis. Implications for climate policy are considered.
Driving Semiconductor Innovation: Moore’s Law at Fairchild and Intel
Authors: LÉCUYER CHRISTOPHE
Published: September 2020

Gordon Moore designed Moore’s Law as a multifunctional tool to drive process and product innovation, sell Fairchild’s and Intel’s microchips, and outcompete other semiconductor firms. Because Intel’s ability to stay on Moore’s Law depended upon other corporations developing materials and manufacturing equipment for exponential scaling, Moore and his closest associates heavily promoted Moore’s Law in the microelectronics community. They also established the national and international technology roadmaps for semiconductors in order to set the direction and cadence of innovation in microelectronics at the national and, later, global scales. Moore’s and his successors’ relentless pursuit of Moore’s Law and their deft management of the roadmaps significantly reinforced Intel’s competitiveness and helped it to dominate semiconductor technology and industry until the mid-2010s.
Early feeding with hyperglucidic diet during fry stage exerts long-term positive effects on nutrient metabolism and growth performance in adult tilapia (Oreochromis niloticus)
Authors: Kumkhong Suksan , Marandel Lucie , Plagnes-Juan Elisabeth , Veron Vincent , Panserat Stephane , Boonanuntanasarn Surintorn
Published: September 2020

The present study aimed to investigate nutritional programming of carbohydrate metabolism in Nile tilapia. Early nutritional intervention stimulus was achieved by feeding fry with high-protein/low-carbohydrate (HP/LC) or low-protein/high-carbohydrate (LP/HC) diet since first feeding for 4 weeks, and the effect of nutritional stimulus on carbohydrate and its related metabolism was evaluated through the adult stage. Our findings indicated that at week 1, LP/HC diet-fed fry had lower levels of mRNA for genes coding gluconeogenesis and amino acid catabolism and higher levels ofhk2 (P< 0⋅05). As expected, in adult tilapia, although LP/HC diet-fed fish had poorer growth (end of stimulus), the fish showed compensatory growth. There were permanent effects of early high-carbohydrate (HC) intake on several parameters, including (1) modulating hepatic composition, (2) increased muscle glycogen, (3) lower levels of enzymes involved in amino acid catabolism and (4) higher levels of glycolytic enzymes in glycolysis. Finally, HP/LC diet- and LP/HC diet-fed fish were challenged with different dietary carbohydrate levels. Irrespective of challenging diets, the early HC stimulus had significant effects on adult tilapia by (1) promoting utilisation of glucose, which had protein-sparing effects for better growth, (2) inducting lipogenesis and (3) decreasing amino acid catabolism. Taken together, for the first time, we demonstrated that early HC feeding was effective for positive nutritional programming of metabolism in Nile tilapia (an omnivorous fish). It led to the improvement of growth performance in adult fish associated with early feeding, which is linked to a better ability to use glucose, to induce lipogenesis, and to suppress amino acid catabolism.
MULTIDIMENSIONAL EXACT CLASSES, SMOOTH APPROXIMATION AND BOUNDED 4-TYPES
Authors: WOLF DANIEL
Published: September 2020

In connection with the work of Anscombe, Macpherson, Steinhorn and the present author in [1] we investigate the notion of a multidimensional exact class (R-mec), a special kind of multidimensional asymptotic class (R-mac) with measuring functions that yield the exact sizes of definable sets, not just approximations. We use results about smooth approximation [24] and Lie coordinatization [13] to prove the following result (Theorem 4.6.4), as conjectured by Macpherson: For any countable language$\mathcal {L}$and any positive integerdthe class$\mathcal {C}(\mathcal {L},d)$of all finite$\mathcal {L}$-structures with at mostd4-types is a polynomial exact class in$\mathcal {L}$, where a polynomial exact class is a multidimensional exact class with polynomial measuring functions.
Colonial Trademark: Law and Nationality in Mandate Palestine, 1922–48
Authors: Birnhack Michael D.
Published: September 2020

Trademark law protects distinctive signs of products against unauthorized uses. It is a legal tool to enhance market efficiency by conveying information about the origin of goods to consumers. Trademarks are also carriers of cultural information about the manufacturers, their products, and their message to the consumers. Thus, trademarks provide an unexpected reflection on society. This article explores the history of trademark law in Mandate Palestine, from the enactment of the first law to the end of the mandate (1922–48) in three cumulative avenues. First, a legal history analysis is provided, which seeks to understand why the British imposed trademark law at the time and manner they chose and how it was received by the local communities. Second, an empirical study of trademark data is given that reveals why the original trademark registry did not survive and how it was reconstructed for the current study. Trademark data offer an understudied and rich resource indicating economic changes and the reception of the law. Third, a semiotic analysis is provided that examines the trademarks themselves, focusing on local trademarks. Nationality is the common thread in these inquiries. The research reveals the differential reception of the British trademark law, with the Jewish population embracing it and the Arab-Palestinian population being much less receptive to it. The Jewish traders often used trademarks to convey national Zionist messages.
Evidence that more than a third of Paleozoic articulate brachiopod genera (Strophomenata) lived infaunally
Authors: Stanley Steven M.
Published: September 2020

The Strophomenata, which includes two large orders, the Strophomenida and Productida, is the largest group of Paleozoic brachiopods. Nearly all uncemented strophomenatans possessed an unusual concave brachial valve. Most of these have been considered to have lived epifaunally, but had they rested on the seafloor, not only would they have faced intense predation, but their physical instability would have been fatal. I conclude that nearly all strophomenatans, like similar concavo-convex pectinid bivalves, lived infaunally by ejecting water to create a pit into which they descended, to be protected by sediment covering the concave valve. Strophomenatans have been discovered with this sediment preserved in place. If exhumed and turned upside down, a strophomenatan could have righted itself by squirting water. Many productides had anchoring spines, and some had hinge areas with stabilizing flanges. Small spines on the brachial valves of some productides served to trap disguising sediment. Evolutionary loss of hinge teeth within both the Strophomenida and Productida reduced the friction of valve clapping. Partly because of their slender shape, strophomenides were typically more vulnerable to exhumation than productides. Strophomenides also ejected water less effectively than productides and would have been less adept at righting themselves. The virtual disappearance of the strophomenides during the Devonian can be attributed to their vulnerability to intensifying benthic bulldozing and predation. The success of the productides during the late Paleozoic can be attributed to their relatively deep sequestration in the sediment and ability to right themselves and reburrow effectively when exhumed and overturned.
The Funerary Architecture of the La Tène Period in North-western Gaul and Southern Britain
Authors: Vannier Emilie
Published: September 2020

This paper concerns the architecture of formal burials from the La Tène period in north-western Gaul and southern Britain. The research focuses on the shape and dimensions of sepulchral pits containing inhumed or burnt human remains, on the different materials used for the internal elements, and the external constructions and structures covering, framing, or marking the burials. The study of these data exposes the preferred choices in the funerary architecture of Gallic and British communities during the last five centuries bc. The results reveal different regional funerary groups within three main cross-Channel zones according to the architectural elements of the graves and the main treatments of the body. The distinct characteristics of these groups highlight their common features and relationships with neighbouring areas of the Continental and Atlantic zones.
Stress-related cognitive style is related to volumetric change of the hippocampus and FK506 binding protein 5 polymorphism in post-traumatic stress disorder
Authors: Yun Je-Yeon , Jin Min Jin , Kim Sungkean , Lee Seung-Hwan
Published: September 2020

Background

Patients with post-traumatic stress disorder (PTSD) show a different stress-related cognitive style compared with healthy controls (HC). The FK506 binding protein 5 gene (FKBP5), one of the PTSD known risk factors, is involved in the stress response through the hypothalamic-pituitary-adrenal axis and brain volumetric alterations. The present study aimed to uncover the neural correlates of stress-related cognitive styles through the analysis of the regional brain volumes and FKBP5 genotype in patients with PTSD compared with HC.

Methods

In this study, 51 patients with PTSD and 94 HC were assessed for stress-related cognitive styles, PTSD symptoms severity, and genotype of FKBP5 single nucleotide polymorphisms, and underwent T1-weighted structural magnetic resonance imaging. Diagnosis-by-genotype interaction for regional brain volumes was examined in 16 brain regions of interest.

Results

Patients with PTSD showed significantly higher levels of catastrophizing, ruminative response, and repression, and reduced distress aversion and positive reappraisal compared with HC (p < 0.001). Significant diagnosis-by-genotype interactions for regional brain volumes were observed for bilateral hippocampi and left frontal operculum. A significant positive correlation between the severity of the repression and left hippocampal volume was found in a subgroup of patients with PTSD with FKBP5 rs3800373 (AA genotype) or rs1360780 (CC genotype).

Conclusions

The present study showed the influences of FKBP5 genotype on the distorted cognitive styles in PTSD by measuring the volumetric alteration of hippocampal regions, providing a possible role of the hippocampus and left frontal operculum as significant neurobiological correlates of PTSD.
Posttraumatic stress disorder and complex posttraumatic stress disorder in UK police officers
Authors: Brewin Chris R. , Miller Jessica K. , Soffia Magdalena , Peart Alexandra , Burchell Brendan
Published: September 2020

Background

We investigated work-related exposure to stressful and traumatic events in police officers, including repeated exposure to traumatic materials, and predicted that ICD-11 complex PTSD (CPTSD) would be more prevalent than posttraumatic stress disorder (PTSD). The effects of demographic variables on exposure and PTSD were examined, along with whether specific types of exposure were uniquely associated with PTSD or CPTSD.

Methods

An online survey covering issues about trauma management, wellbeing and working conditions was disseminated via social media and official policing channels throughout the UK. In total, 10 401 serving police officers self-identified as having been exposed to traumatic events. Measurement of PTSD and CPTSD utilised the International Trauma Questionnaire.

Results

The prevalence of PTSD was 8.0% and of CPTSD was 12.6%. All exposures were associated with PTSD and CPTSD in bivariate analyses. Logistic regression indicated that both disorders were more common in male officers, and were associated independently with frequent exposure to traumatic incidents and traumatic visual material, and with exposure to humiliating behaviours and sexual harassment, but not to verbal abuse, threats or physical violence. Compared to PTSD, CPTSD was associated with exposure to humiliating behaviours and sexual harassment, and also with lower rank and more years of service.

Conclusions

CPTSD was more common than PTSD in police officers, and the data supported a cumulative burden model of CPTSD. The inclusion in DSM-5 Criterion A of work-related exposure to traumatic materials was validated for the first time. Levels of PTSD and CPTSD mandate enhanced occupational mental health services.
Accelerated cortical thinning and volume reduction over time in young people at high genetic risk for bipolar disorder
Authors: Roberts G. , Lenroot R. , Overs B. , Fullerton J. , Leung V. , Ridgway K. , Stuart A. , Frankland A. , Levy F. , Hadzi-Pavlovic D. , Breakspear M. , Mitchell P. B.
Published: September 2020

Background

Bipolar disorder (BD) is a familial psychiatric disorder associated with frontotemporal and subcortical brain abnormalities. It is unclear whether such abnormalities are present in relatives without BD, and little is known about structural brain trajectories in those at risk.

Method

Neuroimaging was conducted at baseline and at 2-year follow-up interval in 90 high-risk individuals with a first-degree BD relative (HR), and 56 participants with no family history of mental illness who could have non-BD diagnoses. All 146 subjects were aged 12–30 years at baseline. We examined longitudinal change in gray and white matter volume, cortical thickness, and surface area in the frontotemporal cortex and subcortical regions.

Results

Compared to controls, HR participants showed accelerated cortical thinning and volume reduction in right lateralised frontal regions, including the inferior frontal gyrus, lateral orbitofrontal cortex, frontal pole and rostral middle frontal gyrus. Independent of time, the HR group had greater cortical thickness in the left caudal anterior cingulate cortex, larger volume in the right medial orbitofrontal cortex and greater area of right accumbens, compared to controls. This pattern was evident even in those without the new onset of psychopathology during the inter-scan interval.

Conclusions

This study suggests that differences previously observed in BD are developing prior to the onset of the disorder. The pattern of pathological acceleration of cortical thinning is likely consistent with a disturbance of molecular mechanisms responsible for normal cortical thinning. We also demonstrate that neuroanatomical differences in HR individuals may be progressive in some regions and stable in others.
A Systematic Review of the Psychometric Properties of the Geriatric Anxiety Inventory
Authors: Champagne Alexandra , Landreville Philippe , Gosselin Patrick
Published: September 2020

The Geriatric Anxiety Inventory (GAI) and its short form (GAI-SF) are self-reported scales used internationally to assess anxiety symptoms in older adults. In this study, we conducted the first critical comprehensive review of these scales’ psychometric properties. We rated the quality of 31 relevant studies with the COSMIN checklist. Both the GAI and GAI-SF showed adequate internal consistency and test-retest reliability. Convergent validity indices were highest with generalized anxiety measures; lowest with instruments relating to somatic symptoms. We detected substantial overlap with depression measures. While there was no consensus on the GAI’s factorial structure, we found the short version to be unidimensional. Although we found good sensitivity and specificity for detecting anxiety, cut-off scores varied. The GAI and GAI-SF are relevant instruments showing satisfactory psychometric properties; to broaden their use, however, some psychometric properties warrant closer examination. This review calls attention to weaknesses in the methodological quality of the studies.
Pediatric Deep Brain Stimulation for Dystonia: Current State and Ethical Considerations
Authors: MUÑOZ KATRINA A. , BLUMENTHAL-BARBY JENNIFER , STORCH ERIC A. , TORGERSON LAURA , LÁZARO-MUÑOZ GABRIEL
Published: September 2020

Dystonia is a movement disorder that can have a debilitating impact on motor functions and quality of life. There are 250,000 cases in the United States, most with childhood onset. Due to the limited effectiveness and side effects of available treatments, pediatric deep brain stimulation (pDBS) has emerged as an intervention for refractory dystonia. However, there is limited clinical and neuroethics research in this area of clinical practice. This paper examines whether it is ethically justified to offer pDBS to children with refractory dystonia. Given the favorable risk-benefit profile, it is concluded that offering pDBS is ethically justified for certain etiologies of dystonia, but it is less clear for others. In addition, various ethical and policy concerns are discussed, which need to be addressed to optimize the practice of offering pDBS for dystonia. Strategies are proposed to help address these concerns as pDBS continues to expand.
Psychiatric Interventions in Virtual Reality: Why We Need an Ethical Framework
Authors: MARLOTH MARIA , CHANDLER JENNIFER , VOGELEY KAI
Published: September 2020

Recent improvements in virtual reality (VR) allow for the representation of authentic environments and multiple users in a shared complex virtual world in real time. These advances have fostered clinical applications including in psychiatry. However, although VR is already used in clinical settings to help people with mental disorders (e.g., exposure therapy), the related ethical issues require greater attention. Based on a thematic literature search the authors identified five themes that raise ethical concerns related to the clinical use of VR: (1) reality and its representation, (2) autonomy, (3) privacy, (4) self-diagnosis and self-treatment, and (5) expectation bias. Reality and its representation is a theme that lies at the heart of VR, but is also of specific significance in a clinical context when perceptions of reality are concerned, for example, during psychosis. Closely associated is the autonomy of VR users. Although autonomy is a much-considered topic in biomedical ethics, it has not been sufficiently discussed when it comes to applications of VR in psychiatry. In this review, the authors address the different themes and recommend the development of an ethical framework for the clinical use of VR.
Harm, Consent, and Virtual Selves in Full-Body Ownership Illusions: Real Concerns for Immersive Virtual Reality Therapies
Authors: BOTERO MARIA , WHATLEY ELISE
Published: September 2020

This paper analyzes in the use of virtual reality when used to induce full-body ownership in violent offenders in order to elicit empathetic feelings by allowing them to embody the virtual body of a victim of domestic abuse. The authors explore potentially harmful effects to individuals participating in this kind of therapy and question whether consent is fully informed. The paper concludes with guidelines for ethical research and rehabilitation using this innovative technology.
The Emergence of Alphabetic Writing:Tlahcuiloh and Escribano in Sixteenth-Century Mexico
Authors: Mundy Barbara E.
Published: September 2020

Over the course of the sixteenth century in Mexico (New Spain), alphabetic writing replaced pictography as the chosen form of written expression in indigenous communities. A new social role, that of the native languageescribano(notary), emerged, eventually to become a principal cultural broker in the colonial period. Despite the indigenous escribano's importance, his origins and the source of his authority within the native sphere are poorly understood. This article offers a close reading of a corpus of hybrid pictographic-alphabetic documents, written in Nahuatl and created between 1553 and 1572 in the indigenouscabildo(town council) of Mexico-Tenochtitlan. Within this important body, escribanos appear early in the documentary record; it was within the established indigenous ecosystem of governance that escribanos first found a niche.

Here, pictography flourished, as did performances unique to the indigenous sphere. The corpus reveals how escribanos worked side by side with indigenoustlahcuilohqueh, or painters, who drew on a long-established tradition of manuscript painting and cartography to create property maps. These maps adhered to established codes, both social and visual. Initially preeminent in itself, the work of thetlahcuilohquehcame to supply meaning and public authority to the work of the escribano in this crucial formative period.
Hybridisation of perovskite nanocrystals with organic molecules for highly efficient liquid scintillators
Authors: Cho Sangeun , Kim Sungwoo , Kim Jongmin , Jo Yongcheol , Ryu Ilhwan , Hong Seongsu , Lee Jae-Joon , Cha SeungNam , Nam Eun Bi , Lee Sang Uck , Noh Sam Kyu , Kim Hyungsang , Kwak Jungwon , Im Hyunsik
Published: September 2020

Compared with solid scintillators, liquid scintillators have limited capability in dosimetry and radiography due to their relatively low light yields. Here, we report a new generation of highly efficient and low-cost liquid scintillators constructed by surface hybridisation of colloidal metal halide perovskite CsPbA3 (A: Cl, Br, I) nanocrystals (NCs) with organic molecules (2,5-diphenyloxazole). The hybrid liquid scintillators, compared to state-of-the-art CsI and Gd2O2S, demonstrate markedly highly competitive radioluminescence quantum yields under X-ray irradiation typically employed in diagnosis and treatment. Experimental and theoretical analyses suggest that the enhanced quantum yield is associated with X-ray photon-induced charge transfer from the organic molecules to the NCs. High-resolution X-ray imaging is demonstrated using a hybrid CsPbBr3 NC-based liquid scintillator. The novel X-ray scintillation mechanism in our hybrid scintillators could be extended to enhance the quantum yield of various types of scintillators, enabling low-dose radiation detection in various fields, including fundamental science and imaging.
Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity
Authors: Kozlova Elena V , Hegde Shivanand , Roundy Christopher M , Golovko George , Saldaña Miguel A , Hart Charles E , Anderson Enyia R , Hornett Emily A , Khanipov Kamil , Popov Vsevolod L , Pimenova Maria , Zhou Yiyang , Fovanov Yuriy , Weaver Scott C , Routh Andrew L , Heinz Eva , Hughes Grant L
Published: September 2020

How microbe–microbe interactions dictate microbial complexity in the mosquito gut is unclear. Previously we found that, Serratia, a gut symbiont that alters vector competence and is being considered for vector control, poorly colonized Aedes aegypti yet was abundant in Culex quinquefasciatus reared under identical conditions. To investigate the incompatibility between Serratia and Ae. aegypti, we characterized two distinct strains of Serratia marcescens from Cx. quinquefasciatus and examined their ability to infect Ae. aegypti. Both Serratia strains poorly infected Ae. aegypti, but when microbiome homeostasis was disrupted, the prevalence and titers of Serratia were similar to the infection in its native host. Examination of multiple genetically diverse Ae. aegypti lines found microbial interference to S. marcescens was commonplace, however, one line of Ae. aegypti was susceptible to infection. Microbiome analysis of resistant and susceptible lines indicated an inverse correlation between Enterobacteriaceae bacteria and Serratia, and experimental co-infections in a gnotobiotic system recapitulated the interference phenotype. Furthermore, we observed an effect on host behavior; Serratia exposure to Ae. aegypti disrupted their feeding behavior, and this phenotype was also reliant on interactions with their native microbiota. Our work highlights the complexity of host–microbe interactions and provides evidence that microbial interactions influence mosquito behavior.
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans
Authors: Salvadore Giacomo , Bonaventure Pascal , Shekhar Anantha , Johnson Philip L. , Lord Brian , Shireman Brock T. , Lebold Terry P. , Nepomuceno Diane , Dugovic Christine , Brooks Sander , Zuiker Rob , Bleys Cathy , Tatikola Kanaka , Remmerie Bart , Jacobs Gabriel E. , Schruers Koen , Moyer John , Nash Abigail , Van Nueten Luc G. M. , Drevets Wayne C.
Published: September 2020

Orexin neurons originating in the perifornical and lateral hypothalamic area project to anxiety- and panic-associated neural circuitry, and are highly reactive to anxiogenic stimuli. Preclinical evidence suggests that the orexin system, and particularly the orexin-1 receptor (OX1R), may be involved in the pathophysiology of panic and anxiety. Selective OX1R antagonists thus may constitute a potential new treatment strategy for panic- and anxiety-related disorders. Here, we characterized a novel selective OX1R antagonist, JNJ-61393215, and determined its affinity and potency for human and rat OX1R in vitro. We also evaluated the safety, pharmacokinetic, and pharmacodynamic properties of JNJ-61393215 in first-in-human single- and multiple-ascending dose studies conducted. Finally, the potential anxiolytic effects of JNJ-61393215 were evaluated both in rats and in healthy men using 35% CO2 inhalation challenge to induce panic symptoms. In the rat CO2 model of panic anxiety, JNJ-61393215 demonstrated dose-dependent attenuation of CO2-induced panic-like behavior without altering baseline locomotor or autonomic activity, and had minimal effect on spontaneous sleep. In phase-1 human studies, JNJ-61393215 at 90 mg demonstrated significant reduction (P < 0.02) in CO2-induced fear and anxiety symptoms that were comparable to those obtained using alprazolam. The most frequently reported adverse events were somnolence and headache, and all events were mild in severity. These results support the safety, tolerability, and anxiolytic effects of JNJ-61393215, and validate CO2 exposure as a translational cross-species experimental model to evaluate the therapeutic potential of novel anxiolytic drugs.
Biodegradability of poly(3-hydroxyalkanoate) and poly(ε-caprolactone) via biological carbon cycles in marine environments
Authors: Suzuki Miwa , Tachibana Yuya , Kasuya Ken-ichi
Published: September 2020

Approximately 4.8–12.7 million tons of plastic waste has been estimated to be discharged into marine environments annually by wind and river currents. The Ellen MacArthur Foundation warns that the total weight of plastic waste in the oceans will exceed the total weight of fish in 2050 if the environmental runoff of plastic continues at the current rate. Hence, biodegradable plastics are attracting attention as a solution to the problems caused by plastic waste. Among biodegradable plastics, polyhydroxyalkanoates (PHAs) and poly(ε-caprolactone) (PCL) are particularly noteworthy because of their excellent marine biodegradability. In this review, the biosynthesis of PHA and cutin, a natural analog of PCL, and the biodegradation of PHA and PCL in carbon cycles in marine ecosystems are discussed. PHA is biosynthesized and biodegraded by various marine microbes in a wide range of marine environments, including coastal, shallow-water, and deep-sea environments. Marine cutin is biosynthesized by marine plants or obtained from terrestrial environments, and PCL and cutin are biodegraded by cutin hydrolytic enzyme-producing microbes in broad marine environments. Thus, biological carbon cycles for PHA and PCL exist in the marine environment, which would allow materials made of PHA and PCL to be quickly mineralized in marine environments.
Assembly intermediates of orthoreovirus captured in the cell
Authors: Sutton Geoff , Sun Dapeng , Fu Xiaofeng , Kotecha Abhay , Hecksel Corey W. , Clare Daniel K. , Zhang Peijun , Stuart David I. , Boyce Mark
Published: September 2020

Traditionally, molecular assembly pathways for viruses are inferred from high resolution structures of purified stable intermediates, low resolution images of cell sections and genetic approaches. Here, we directly visualise an unsuspected ‘single shelled’ intermediate for a mammalian orthoreovirus in cryo-preserved infected cells, by cryo-electron tomography of cellular lamellae. Particle classification and averaging yields structures to 5.6 Å resolution, sufficient to identify secondary structural elements and produce an atomic model of the intermediate, comprising 120 copies each of protein λ1 and σ2. This λ1 shell is ‘collapsed’ compared to the mature virions, with molecules pushed inwards at the icosahedral fivefolds by ~100 Å, reminiscent of the first assembly intermediate of certain prokaryotic dsRNA viruses. This supports the supposition that these viruses share a common ancestor, and suggests mechanisms for the assembly of viruses of the Reoviridae. Such methodology holds promise for dissecting the replication cycle of many viruses.
Catalytic asymmetric C–Si bond activation via torsional strain-promoted Rh-catalyzed aryl-Narasaka acylation
Authors: Feng Jia , Bi Xiufen , Xue Xiaoping , Li Na , Shi Lei , Gu Zhenhua
Published: September 2020

Atropisomers are important organic frameworks in bioactive natural products, drugs as well as chiral catalysts. Meanwhile, silanols display unique properties compared to their alcohol analogs, however, the catalytic synthesis of atropisomers bearing silanol groups is challenging. Here, we show a rhodium-catalyzed torsional strain-promoted asymmetric ring-opening reaction for the synthesis of α-silyl biaryl atropisomers. The reaction features a dynamic kinetic resolution of C(Ar)-Si bond cleavage, whose stereochemistry was controlled by a phosphoramidite ligand derived from (S)-3-methyl-1-((2,4,6-triisopropylphenyl)sulfonyl)piperazine. This work is a demonstration of an aryl-Narasaka acylation, where the C(Ar)-Si bond cleavage is promoted by the torsional strain of α, α’-disubstituted silafluorene.