bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of row spacing on biomass production of bioenergy grass species in wet marginal land
Authors: Thapa Santanu , Vittore Kayla M. , Allen Dylan P. , Guo Jia , Lee Moon-Sub , Lee D.K.
Published: July 2022

Demand for energy and the environmental consequences associated with emissions have created a need for alternative energy sources. To avoid conflict over distributing agricultural land to fuel crops rather than food, bioenergy crops could instead be cultivated on marginal land. This study compared the performance of bioenergy candidate crops including M. × giganteus, switchgrass, big bluestem, and prairie cordgrass when cultivated on the same waterlog-prone marginal land. Across all treatments, annual biomass yield was 14.16 Mg ha− 1. Row spacing had significant impacts on productivity for these species. Higher biomass yields were observed in 45cm spacing than in 90cm spacing. Additionally, the biomass yield responses to row spacings varied depending on grass species, which may be due to rhizome structure and vegetative growth types. Regarding feedstock quality, feedstock composition (cellulose, hemicellulose, lignin, and ash concentration) was not influenced by row spacing, and did not deviated from grass species grown on agricultural lands. During experimental periods, our results provide evidence that all four grass species could be cultivated on waterlogged marginal land while maintaining comparable biomass yields.
De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
Authors: Vinson David A. , Stephens Kimberly E. , O'Meally Robert N. , Bhat Shri , Dancy Blair CR , Cole Robert N. , Yegnasubramanian Srinivasan , Taverna Sean D.
Published: July 2022

Epigenetic modifications to histone proteins serve an important role in regulating permissive and repressive chromatin states, but despite the identification of many histone PTMs and their perceived role, the epigenetic writers responsible for generating these chromatin signatures are not fully characterized. Here we report that the canonical histone H3K9 methyltransferases EHMT1/GLP and EHMT2/G9a are capable of catalyzing methylation of histone H3 lysine 23 (H3K23). Our data shows that while both enzymes can mono- and di-methylate H3K23, only EHMT1/GLP can tri-methylate H3K23. We also show that pharmacologic inhibition or genetic ablation of EHMT1/GLP and/or EHMT2/G9a leads to decreased H3K23 methylation in mammalian cells. Taken together, this work identifies H3K23 as a new direct methylation target of EHMT1/GLP and EHMT2/G9a, and highlights the differential activity of these enzymes on H3K23 as a substrate.
Detection and diagnosis of cleidocranial dysplasia by panoramic radiography
Authors: Shi Yuchao , Ye Zelin , Liu Yuanyuan , Wang Hu , You Meng
Published: July 2022

BackgroundThe purpose of this study was to illustrate and quantify the maxillofacial bone abnormalities detected on panoramic radiographs from a group of Chinese patients with cleidocranial dysplasia (CCD) and to provide a series of diagnostic references for dentists to indicate the presence of disease and help in making an early and accurate diagnosis.Materials and methodsThe dental panoramic radiographs of thirty CCD patients aged 11 to 45 years (18 males and 12 females) were examined retrospectively. The dentition states, including supernumerary teeth and impacted teeth, were recorded. Twelve quantified measurements were adopted to determine the abnormalities of maxillofacial bones, including the degree of the zygomatic arch downward bend, bicondylar breadth, ramal height, mandibular height, mandibular aspect ratio, mandibular body height, condylar height, coronoid height, distance between the coronoid process and the condyle, bigonial width, gonial angle and best-fit gonial circle diameter. The Wilcoxon rank-sum test was used to compare the findings of the CCD patients with those of their matched controls (n=300).ResultsSupernumerary teeth were detected in 27 patients (90.0%), and all 30 patients presented impacted teeth. Compared to the matched controls, the CCD patients had a significantly larger degree of zygomatic arch downward bend (ZAD), a larger diameter of the best-fit gonial circle (BGC), and a shorter distance between the coronoid process and the condyle (DCC) in panoramic radiographs (P<0.001). According to the reference interval established from the 5th or 95th percentile of the measurements in the control group, ZAD less than 6.90 mm, DDC greater than 22.37 mm and BGC greater than 52.41 mm were significantly associated with the CCD features identified. Other panoramic measurements were not significantly different between the two groups.ConclusionsIn this study, we identified some featured radiographic parameters of maxillofacial bones in CCD patients. These features can be recognized in commonly used dental radiographs and therefore may provide valuable information for the early diagnosis and treatment of CCD.
Contextual factors influencing the implementation of a new midwife education programme in India: A qualitative study
Authors: Erlandsson Kerstin , Jha Paridhi , Sharma Bharati , Bogren Malin
Published: July 2022

The Government of India has committed to educate 90,000 midwives in accordance with international norms. This goal is critical as midwives save lives through providing evidence-based, high-quality midwifery care. There is a need to explore the contextual factors influencing this new midwifery education programme. Hence, the aim of this study is to explore contextual factors influencing the implementation of the national midwifery education programme for midwifery educators and the future Nurse Practitioners in Midwifery (NPMs) in India. A qualitative research design was used, with data collected through focus group discussions (n=8) with a total of 27 participants representing seven national and international organisations supporting the Indian Government in its midwifery initiative. Transcribed interviews were analysed using content analysis according to Elo and Kyngas. This study on contextual factors influencing the implementation of the new midwifery education programme in India showed that organisation and administrative processes are complex and the production of midwifery educators and nurse practitioners in midwifery needs to be fast tracked. The education of educators and future midwives in India, and elsewhere in similar settings, could benefit from efforts to simplify the organisation and administration processes and, in parallel, mobilize innovative teaching and learning approaches to bridge theory and practice.
Low carbon transition of global power sector may enhance sustainable development goals
Authors: Peng Kun , Feng Kuishuang , Chen Bin , Shan Yuli , Zhang Ning , Wang Peng , Fang Kai , Bai Yanchao , Zou Xiaowei , Wei Wendong , Geng Xinyi , Zhang Yiyi , Li Jiashuo
Published: July 2022

Low-carbon power transition, key to combatting climate change, brings far-reaching effects on achieving Sustainable Development Goals (SDGs), in terms of resources use, environmental emissions, employment, and many more. Here we assess the potential impacts of power transition on multiple SDGs progress across 49 economies under six socio-economic-climate scenarios. We find that the low carbon power transition under Representative Concentration Pathway (RCP) 2.6 scenarios could lead to approximately 10% improvement in global SDG index score from 65.30 in 2015 to 71.62–71.64 in 2050. However, the improvement would be significantly decreased to 1.91%-4.98% and 3.42%-5.24% under RCP6.0 and RCP4.5 scenarios, respectively. Power transition could improve the overall SDG index in most developed economies under all scenarios while undermine their resources-related SDG scores. The power transition induced changes in international trade would improve developed economies’ SDG progress, but jeopardize that of developing economies which usually serve as resource hubs to meet the demand for low carbon power transition in developed economies.
HYOU1 promotes cell prolifetaion, migration and invasion via PI3K/ATT/FOXO1 feedback loop in bladder cancer
Authors: Wang Weiguo , Jiang Xinjie , Xia Fei , Chen Xudong , Li Guojun , Liu Lizhuan , Xu Qiang , Zhu Min , chen cheng
Published: July 2022

Background: Hypoxia up-regulated 1 (HYOU1) was identified as a proto-oncogene and involved in tumorigenesis and progression in several cancer. Nonetheness, the biological function and mechanism of HYOU1 in bladder cancer (BCa) remian unclear.Methods: The HYOU1 level in BCa tissues and cells was examined using RT-qPCR and western blot method. The biological role of HYOU1 on BCa cell proliferation, apoptosis, migration and invasion were analyzed via CCK-8, flow cytometry, wound healing and Transwell assays, respectively. The association between HYOU1 and the PI3K/AKT/FOXO1 signalling was assessed via western blot assay, meanwhile the the association of FOXO1 with HYOU1 was also investigated.Results: HYOU1 was up-regulated in BCa tissues and cell lines. The increased expression level of HYOU1 was indicated the poor prognosis. HYOU1 depletion impeded cell proliferation, migration and invasion, and induced cell apoptosis, while HYOU1 overexpression promoted cell proliferation, migration and invasion. Mechanically, our results showed that HYOU1 knockdown repressed PI3K/AKT/FOXO1 pathway and HYOU1 was negative regulated by FOXO1 in BCa. Significantly, we confirmed that the HYOU1/PI3K-AKT/FOXO1 negative feedback loop was involved in BCa cell proliferation, migration and invasion. Conclusions: These findings revealed that HYOU1 acted as a pro-oncogene on BCa developent and progression, and it will be a possible target for BCa treatment.
Disproportionality Analysis of Tumour Lysis Syndrome (TLS) Associated with Bruton's Tyrosine Kinase Inhibitor (BTKi) using Food and Drug Administration Adverse Events Reporting System (FAERS) Database
Authors: Zeba Zeba , Shettigar Amrutha , Lukose Lipin , Kaur Gursimran , Nair Gouri , Haider Nafis , Thomas Levin , Subeesh Viswam , Rao Mahadev
Published: July 2022

Background: Bruton's tyrosine kinase inhibitors (BTKis) are used for treating B-cell leukaemia and lymphomas like chronic lymphocytic leukaemia, mantle cell lymphoma, and Waldenström macroglobulinemia. Tumour lysis syndrome (TLS) is an adverse event associated with this class, the prevalence of which is not well studied in an actual context. Objective: This study aims to detect the possible safety signal of BTKis-associated with TLS through disproportionality analysis in the Food and Drug Administration Adverse Event Reporting System (FAERS) database. Patients and Methods: A case/non-case retrospective disproportionality analysis was performed in a publicly available FAERS database using OpenVigil 2.1 (2014Q1-2021Q3). The preferred term defined by MedDRA v24 used for the study was "tumour lysis syndrome" and the drugs included in the analysis were acalabrutinib, ibrutinib, and zanubrutinib. Reporting odds ratio (ROR) was used as the analysis data mining algorithm. Results: 2852 cases of TLS were identified from FAERS database, of which 121 (4.2%) reports were associated with BTKis. Ibrutinib accounted for 103 (85.1%), acalabrutinib for 15 (12.4%), and zanubrutinib for 3 (2.5%) cases of TLS reports associated with BTKis. Positive signal strength was obtained for ibrutinib [ROR 13.5 (95%CI: 11.1-16.4), acalabrutinib [ROR 42.8 (25.7-71.3), and zanubrutinib [ROR 72.4 (23-227.5)] associated TLS. On gender stratification, acalabrutinib and ibrutinib were found to have a higher value (ROR of 1.7 times) for females than males. Conclusion: Our analysis of spontaneous reporting data identified signals for TLS with acalabrutinib, ibrutinib, and zanubrutinib. More research with a superior epidemiological study design of a defined population is required to validate these findings.
Network analysis and basic experiments on the inhibition of renal cancer proliferation and migration by alpinetin through PI3K/AKT/mTOR pathway
Authors: Guo Yu , Jiang Li , Luo Shengjun , Hu Daixing , Zhao Xin , Zhao Guozhi , Tang Wei
Published: July 2022

To investigated the antitumor effect of on renal clear cell carcinoma (ccRCC). Network Pharmacology analysis of targets and molecular mechanisms of Alpinetin treating ccRCC. The Annexin V PE/7-AAD kit was used to detect apoptosis. Flow cytometry and Cell Counting Kit-8 (CCK-8) were used to detect cell proliferation and cycle. Cell migration analysis was performed by a 24-well transwell chamber and the ibidi scratch insert. The protein expression of the target molecule was detected by Western blotting. Nude mouse tumorigenesis assays were used to determine the in vivo antitumor effects of alpinetin. Network pharmacology revealed that GAPDH, HRAS, SRC, EGFR, and AKT1 are the main targets of alpinetin for the treatment of ccRCC, with the PIK/AKT signaling pathway being the main pathway of action. Alpinetin could significantly inhibit the proliferation and migration of ccRCC cells by inducing apoptosis. Alpinetin also inhibited the cycle progression of ccRCC cells by blocking them in the G1 phase. Furthermore, in vivo and in vitro, alpinetin could inhibit the activation of PI3K/Akt pathway involved in the proliferation and migration of ccRCC. Alpinetin can inhibit the growth of ccRCC cells by inhibiting the activation of PI3K/Akt pathway and can be a potential anti-cancer drug for ccRCC.
How do scarcity promotion and cause-related events lead to impulse purchase in the agricultural product live stream?
Authors: guo mengqian , Li Xiaolin , Huang Dunhu
Published: July 2022

Harvest agricultural products are perishable. If they cannot be sold, there will be serious grain loss and food waste. It is an important issue related to human sustainable development and urgent to address. As the most popular way of shopping, live shopping has achieved remarkable achievements, while the existing research is relatively silent on how to promote the sales of agricultural products in the context of live streams. Based on S-O-R theory and dual-system theory, three studies investigated the intrinsic mechanism of consumers' impulse purchase intention in live streams. The results show that scarcity promotion and cause-related events are positively correlated with consumers' impulse purchase intention. The intrinsic mechanism is respectively arousal and moral elevation. Interestingly, when scarcity promotion and cause-related events are presented at the same time, the impact of cause-related events on impulse purchase is no longer significant. Overall, the proposed model could be used to predict consumers’ willingness and provide the choice of marketing strategy to promote the sale of agricultural products, which has significant theoretical and practical value.
Neural network multi-component gas mixture analysis with broadband dual-frequency comb absorption spectroscopy
Authors: Tian Linbo , Xia Jinbao , Kolomenskii Alexandre , Schuessler Hans , zhu feng , Li Yanfeng , He Jingliang , Dong Qian , Zhang Sasa
Published: July 2022

The cross interference of gas species in absorption spectroscopy is one of the most challenging obstacles for the analysis of multi-component gas mixtures with overlapping absorption features (blended spectra). We propose a multi-component gas mixture sensor combining a broadband absorption spectrum acquisition with a spectrum analysis algorithm. The sensor features a mid-infrared dual-frequency comb laser source enabling sensitive measurements in a broad spectral interval combined with a deep learning algorithm for spectral analysis to accurately identify the species and retrieve the concentrations of the gas components in the mixture. The sensor is tested with gas mixtures of three common gas species, namely methane, acetone and water vapor. The architecture tuning and model training are achieved by a physics-informed augmented dataset. The proposed spectral analysis model is evaluated firstly by comparison with two other state-of-the-art neural network algorithms (2L-ARNN and 1D-CNN). The performance of the complete sensor is then assessed by real-time measurements in realistic detection scenarios. In addition, we systematically analyzed and presented explicit visualizations explaining the inner working mechanism of the considered algorithms. The high performance of the proposed sensor suggests that it is feasible to realize schemes for more general gas mixture analysis by integrating broadband optical sensing and deep learning models.
Skinfold Thickness Pinch Size Can Interfere in the Estimation and Classification of Body Adiposity
Authors: Cintra-Andrade Joaquim Huaina , Brito Filipe Oliveira , Freire-Correia Maria Izabel , Costa Roberto Fernandes , Ripka Wagner Luis
Published: July 2022

The objective was to verify the effect of pinch size on the absolute measure of skinfold thickness and on the consequent interference in the estimation and classification of the components of body adiposity. This was a cross-sectional study conducted with a sample of 29 subjects of both sexes aged 20 to 35 years. The study was conducted in the city of Fortaleza, Ceará, Brazil. Four measurement steps were performed at each site of the eight chosen skinfolds. The first step was performed with a subjective-landmark and the three subsequent steps with fixed-landmarks defined with an expanding secondary line at 2 cm intervals. Body adiposity components were estimated from the skinfold thickness measured at each landmark. Repeated measures ANOVA and Bland-Altman agreement analysis were applied. The subjective-landmark was chosen as the dependent variable. The 6 cm-landmark showed similarity and statistical agreement with the subjective-landmark for all skinfolds except the thigh, and with the sums of five and eight skinfolds. All fixed-landmarks showed agreement below the cut-off point for the percentile classification of subcutaneous adiposity and normative relative body fat. It is concluded that variation in the pinch size of skinfold thickness is a new and important source of technical error in anthropometric measurement.
Automated Meniscus Segmentation and Tear Detection of Knee MRI with a 3D Mask-RCNN
Authors: Li Yuan-Zhe , Wang Yi , Fang Kai-Bin , Zheng Hui-Zhong , Lai Qing-Quan , Xia Yong-Fa , Chen Jia-Yang , Dai Zhang-sheng
Published: July 2022

Background
The diagnostic results of MRI are important references for arthroscopy as an invasive procedure. A deviation between medical imaging diagnosis and arthroscopy results may cause irreversible damage to patients and lead to excessive medical treatment. To improve the accurate diagnosis of meniscus injury, it is urgent to develop auxiliary diagnosis algorithms to improve the accuracy of radiological diagnosis.
Purpose: The purpose of the study is to present a fully automatic 3D deep convolutional neural network (DCNN) for meniscus segmentation and to detect arthroscopically proven meniscus tears.
Materials and methods: Our institution retrospectively included 533 patients with 546 knees who underwent knee magnetic resonance imaging (MRI) and knee arthroscopy. The sagittal proton density-weighted (PDW) images in MRI of 382 knees were regarded as a training set to train our 3D-Mask RCNN. The remaining data from 164 knees were used to validate the trained network as a test set. The masks were hand-drawn by an experienced radiologist, and the reference standard is arthroscopic surgical reports. The performance statistics included Dice accuracy, sensitivity, specificity, FROC, receiver operating characteristic (ROC) curve analysis, and bootstrap test statistics. The segmentation performance was compared with a 3D-Unet, and the detection performance was compared with radiological evaluation by two experienced musculoskeletal radiologists without knowledge of the arthroscopic surgical diagnosis.
Results: Our model produced strong Dice coefficients for sagittal PDW of 0.924, 0.95 sensitivity with 0.823 FPs/knee. 3D-Unet produced a Dice coefficient for sagittal PDW of 0.891, 0.95 sensitivity with 1.355 FPs/knee. The difference in the areas under 3D-Mask-RCNN FROC and 3D-Unet FROC was statistically significant (p=0.0011) by bootstrap test. Our model detection performance achieved an area under the curve (AUC) value, accuracy, and sensitivity of 0.907, 0.924, 0.941, and 0.785, respectively. Based on the radiological evaluations, AUC value, accuracy, sensitivity, and specificity were 0.834, 0.835, 0.889, and 0.754, respectively. The difference in the areas between 3D-Mask-RCNN ROC and radiological evaluation ROC was statistically significant (p=0.0009) by bootstrap test. 3D Mask RCNN significantly outperformed the 3D-Unet and radiological evaluation that were demonstrated by These results.
Conclusion: 3D-Mask RCNN has demonstrated efficacy and precision for meniscus segmentation and tear detection in knee MRI, which can assist radiologists in improving the accuracy and efficiency of diagnosis. It can also provide effective diagnostic indicators for orthopedic surgeons before arthroscopic surgery and further promote precise treatment.
Treatment of single-level lumbar spondylolisthesis by percutaneous endoscopic decompression and fusion (PE-PLIF)
Authors: Gao Zhenwu , Xi Leimin , Feng Haoyu , He Liming , Ma Yongzhuang , Chang Qiang , Wang Rui , Wang Yue
Published: July 2022

Purpose: To investigate the effect of percutaneous endoscopic lumbar decompression and fusion (PE-PLIF) for L4/5 lumbar spondylolisthesis.
Methods: From September 2019 to June 2020, six patients (two men, four women) with l4/5 lumbar spondylolisthesis from the Department of Orthopedics, Bethune Hospital of Shanxi Province were treated with PE-PLIF. Their ages ranged from 43 to 77 years, with an average of (59.66±17.33) years. The duration of operation, blood loss, blood transfusion, and complications were recorded. Results were evaluated by visual analogue scale (VAS) and Oswestry Disability Index (ODI). Student's t- test was used to compare the parameters before and after operation.
Results: Six patients were followed up for an average of 13 months (6~20 months), and their symptoms were significantly improved. VAS scores of low back pain and leg pain at three days (2.19±0.49, 1.47±0.63, respectively) and 24 months (0.41±0.54, 0.24±0.27, respectively) were significantly improved compared with preoperative scores (7.83 ±1.17, 6.50±0.80, respectively). The differences were statistically significant ( t =18.717, 6.771, 17.511, 8.021, all P < 0.001). The ODI score at the last follow-up was also significantly lower than that before surgery (53% ±9% vs 17%±7%, P < 0.001). During the follow-up period, screw extraction occurred in only one patient, and no obvious complications occurred in the other five patients. No complications occurred.
Conclusion: PE-PLIF can achieve satisfactory short-term efficacy in the treatment of single-level lumbar spondylolisthesis with a low complication rate and quick postoperative recovery. It is a safe and effective way to treat single-level lumbar spondylolisthesis.
Hypertensive Retinopathy in Patients With Indications for Kidney Transplantation: A Cross-sectional Study
Authors: Nguyen Le Trung , Toan Pham Quoc , Tuan Vu Anh , Trung Nguyen Kien
Published: July 2022

Purpose: Patients with end-stage renal failure are very susceptible to hypertensive retinopathy. This study explores the relationship between hypertensive retinopathy and risk factors.Methods: The 115 patients with end-stage renal failure are indicated for a kidney transplant. The outcome variable was the hypertensive retinopathy condition of the participants. Wong's classification of hypertensive retinopathy. Using linear regression to evaluate the associationResults: According to levels, the rate of retinal damage due to hypertension is 65.22%. When univariate analysis found the level of visual acuity was statistically significant, the other factors were not statistically significant. In multivariable logistic regression analysis, sex (odds ratio: 3.4, p<0.05), hemodialysis (odd ratio: 3.5, p<0.05), visual acuity (odd ratio: 14.0, p<0.05) is considered to be an influence factor for disease progression.Conclusion: Sex, hemodialysis, visual acuity are factors for hypertensive retinopathy in patients preparing to receive a kidney. These results reinforce the evidence for multifactorial hypertensive retinopathy disease in patients with renal impairment.
The P2Y12 receptor antagonist Ticagrelor ameliorates pulmonary hypertension
Authors: Li Nannan , Yin Jie , Shi Yugen , Sun Li , Zhang Qingshan , Bao Shuai , Zhang Juan , Li Youlei , Wang Miaomiao , Zhang Yanwei , Feng Xue , Cai Weidong , Zhang Hongxing , Li Yan , Yan Suhua , You Shuling , Li Xiaolu
Published: July 2022

Purpose
Pulmonary arterial hypertension (PAH) is a disease that the pulmonary artery is abnormally elevated. P2Y12 is an adenosine diphosphate (ADP) receptor and it act as the target of thienopyridine antiplatelet drugs by controlling vascular remodeling. Inhibition of P2Y12 receptor in the process of PAH was explored in this study.
Methods
The PAH model was established in Sprague-Dawley rats by single subcutaneous injection of 60 mg/kg monocrotaline (MCT). The ticagrelor solution (a selective P2Y12R inhibitor) was intraperitoneally injected into rats at a dose of 14 mg/kg from the time of MCT injection to day 28.
Results
In the lung tissues of PAH rats, the marked P2Y12R was detected. Treatment with ticagrelor greatly decreased P2Y12R level and efficiently abolished the upregulation of α-SMA as demonstrated by Western blot and RT-PCR. The wall thickness and occlusion score of the pulmonary arterioles showed that blockade of P2Y12R could relieve lung remodeling caused by PAH. The haemodynamic changes at 4 weeks determined that P2Y12R inhibition affected RV pressure and right heart hypertrophy.
Conclusions
P2Y12R might be involved in the pathogenesis of PAH. Blockade of P2Y12R has potential in treating PAH.
Participação de Professores no Ambiente Virtual de Aprendizagem em um Curso de Formação Continuada sobre a Base Nacional Comum Curricular
Authors: Zani Fabiana Fernandes , Mazzafera Bernadete Lema , Bianchini Luciane Battistela
Published: July 2022

Este estudo teve por objetivo analisar o processo de formação continuada de docentes de educação básica de um município, fundamentado na Base Nacional Comum Curricular, realizado em ambiente virtual de aprendizagem (AVA), analisando o impacto do uso do AVA na construção do conhecimento acerca do tema. Os objetivos específicos foram descrever as etapas do curso, a participação dos professores no curso e as interações no ambiente virtual de aprendizagem, para, a partir dessas análises, tecer reflexões acerca das experiências de aprendizagem dos professores. O estudo caracteriza-se como uma pesquisa descritiva quantitativa e qualitativa, ex post facto, pois as análises foram realizadas mediante os dados gerados pelo sistema (metadados). Nossas conclusões, a partir da análise de conteúdo, sugerem: no que diz respeito à descrição do curso houve prevalência do uso de vídeos e arquivos em PDF; em relação às interações dos professores com o tutor, foram poucas e não tinham caráter mobilizador ou social e se referiram a dúvidas com as ferramentas utilizadas no curso; quanto à participação dos docentes no curso (análise realizada a partir dos dados gerados pelo sistema), ressalta-se a predominância de visualizações e repetições das atividades avaliativas. Embora diversas atividades tenham apresentado múltiplas entradas, o foco na avaliação predominou.
O conceito de célula no processo de ensino e aprendizagem: Relações entre os modos de fazer ciência, ensinar e aprender
Authors: Pinheiro Regiane Machado de Sousa , Echalar Adda Daniela Lima Figueiredo , Queiroz José Rildo de Oliveira
Published: July 2022

A célula constitui-se como o elemento nuclear do princípio de organização, sendo a unidade básica e a menor parte dos seres vivos. No desenvolvimento histórico do conceito de célula, objetivamos explicitar a inter-relação entre os modos de fazer Ciência e os modos de ensinar e aprender os conceitos biológicos. Esta pesquisa possui caráter teórico e se ampara nos fundamentos do materialismo histórico-dialético e do ensino desenvolvimental. Demonstramos a contribuição do pensamento conceitual para o processo de ensino e aprendizagem e para o desenvolvimento humano. Concluímos ratificando a necessidade de que o ensino do conceito de célula seja realizado de uma maneira mais orgânica ao fazer científico, evidenciando sua relação com o conteúdo produzido historicamente pela humanidade.
As práticas do professor de línguas e o processo de (res)significação do aluno de língua estrangeira
Authors: Silva Duarte Leonardo , Brawerman Albini Andressa
Published: July 2022

O objetivo deste estudo foi investigar a relação entre as práticas dos professores de Língua Estrangeira (LE) e os processos de (res)significação dos alunos. A fim de alcançar esse objetivo, a pesquisa buscou analisar quais práticas os professores de LE de escolas públicas percebem que adotam e de que forma suas práticas trabalham com a noção de significação pelo discurso em LE. A metodologia dispôs de um questionário com 31 questões de múltipla escolha e 9 questões semiabertas. O questionário contou com a participação de 50 professores de LE de todas as regiões brasileiras. Os resultados apontam para uma forte consciência dos professores sobre a importância da interação na sala de aula de LE. Os dados ainda indicam que os professores proporcionam aos alunos o contato com outros procedimentos de significação e identificação e têm uma clara preocupação com a participação social e formação integral dos alunos. Em conclusão, o diálogo promovido com os professores mostra paralelos com as teorias de ensino-aprendizagem de LE que trabalham o discurso em sala de aula.
Jovens Estudantes e Cultura Digital: Aspectos Bioculturais, Sociais e Econômicos
Authors: Junqueira Marili Peres , Cardoso Ana Claudia Moreira , Silva Cristiane Aparecida Fernandes da
Published: July 2022

A sociedade tem se modificado vertiginosamente a partir das novas práticas vinculadas ao mundo digital, incluindo a esfera da educação e especialmente a juventude. Nesse contexto de mudanças, a necessidade de produzir e atualizar conhecimentos sobre as identidades e culturas juvenis mostra-se premente. Assim, este artigo, fruto de uma pesquisa quantitativa com 806 questionários aplicados a estudantes em escolas públicas do Ensino Médio da cidade mineira de Uberlândia, apresenta alguns usos sociodigitais desses jovens, permeados por aspectos bioculturais, sociais e econômicos, como idade, sexo, etnia, religião, região, trabalho e renda familiar. Entre seus resultados, destaca-se o fato de não haver um perfil unívoco de jovem uberlandense da escola pública de Ensino Médio, mas antes distintos perfis que dependem de múltiplos fatores socioeconômicos que, por sua vez, influenciam e são influenciados pela própria cultura digital desses jovens. A pesquisa evidenciou ser possível compreender, simultaneamente, uma juventude global, conectada ao mundo remoto, e local, a partir dos usos digitais de jovens brasileiros, mineiros e uberlandenses que frequentam escolas públicas, cuja cultura digital é profundamente marcada pela intersecção das dimensões econômica, espacial, religiosa e étnica.
Formação de Leitores: As Concepções de Linguagem no Contexto das Práticas Alfabetizadoras
Authors: Cilene Amorim Gomes Kátia , Reis Correia Joelma
Published: July 2022

Este artigo tem como objetivo analisar as concepções de linguagem, no discurso e na prática, de uma professora do 2º ano do Ensino Fundamental. Os dados aqui apresentados constituem-se em um recorte de uma pesquisa realizada no período de 2017 a 2018. Desse recorte surgiram as seguintes questões norteadoras: Quais os impactos das concepções de linguagem na relação ensino e aprendizagem no que diz respeito à alfabetização das crianças? De que maneira o discurso da professora revela o seu foco na alfabetização e como isso reflete-se em sua prática? Como sujeito desta pesquisa temos a professora alfabetizadora da Escola Pública Municipal de Ensino de São Luís, Maranhão, com a qual foi feita entrevista como instrumento de geração de dados, bem como a observação participante. Os estudos estão pautados em Bakhtin e Volochinov (2014), Gontijo (2005, 2014), Kleiman (2013), Coracini (1995), Geraldi (2014), Smith (1989, 1999), Jolibert (1994), entre outros. Como resultados, concluímos que a formação de leitores está relacionada diretamente ao que precisam saber os professores alfabetizadores sobre o ato de ler para o ensino desse objeto cultural.
Sinalizador sonoro de distância para deficientes visuais com sensor ultrassônico HC-SR04
Authors: Queiroz Thifany Kaliny dos Santos de Souza , Sousa Neto Marinaldo Pinheiro de , Queiroz Stefany Kariny dos Santos de Souza
Published: July 2022

É sabido que uma pessoa com deficiência visual enfrenta diversos impasses e dificuldades, sendo a Tecnologia Social uma oportunidade de mitigar esse problema social, atendendo ao mesmo tempo aos quesitos de simplicidade, baixo custo, fácil aplicabilidade e impacto social comprovado. O presente trabalho tem como objetivo geral desenvolver um protótipo de um dispositivo que utiliza pulsos sonoros para advertir deficientes visuais da existência de obstáculos. Para a realização do projeto foi utilizada uma placa Arduino Uno, que possui baixo custo e de fácil programação, sensor ultrassônico, um alto-falante para os sinais sonoros, um display LCD e um LED para o sinal luminoso. Foi feita uma simulação do protótipo em software e a montagem do dispositivo previamente simulado e posteriormente foram realizados os testes com o protótipo. Dessa maneira, o sensor avisa por um sinal sonoro quando existe um obstáculo a uma distância inferior a 2 m, evitando que o deficiente visual sofra algum acidente ou não consiga desviar a tempo do objeto.
Estudo da possibilidade de aplicação de óleos de coco e de soja em substituição de fluidos emulsionáveis no torneamento do aço SAE 1045
Authors: Santos João Batista dos , Lima Ramses Otto Cunha
Published: July 2022

A indústria metal-mecânica é considerada a mais poluidora quando comparada àsoutras industrias devido os rejeitos geradosdurante o processo produtivo. A usinagem, de modo geral, é considerada a operação manufaturada mais amplamente utilizada, nestaindústria. A variedade de materiais e produtos envolvidos nesse processo, causa preocupação quanto ao seu descarte e a saúde do operador. Os fluidos de corte,por exemplo, desempenham um papel muito importante nesse processo, pois, estão diretamente relacionados à tribologia do sistema. Portanto, esse estudo teve como objetivo analisar a influência da utilização do óleo de coco e do óleo de soja, como fluido de corte, no processo de torneamento longitudinal externo de um tarugo de aço SAE 1045, tendo como parâmetro de referência a emulsão. Foram coletados dados da temperatura de corte, corrente consumida pela máquina, o desgaste médio de flanco das ferramentas e a rugosidade da peça. Os parâmetros de usinagem foram mantidos constantes para ambos os fluidos: ap = 1 mm, f = 0,19 mm/rot,Vc = 170 m/min. Os dados obtidos por essa pesquisa demostram que os fluidos vegetais podem ser usados com êxito no processo de torneamento. O óleo de coco apresentou o melhor desempenho dentre os fluidos avaliados.
Estudo dainfluência do método de lubri-refrigeração no acabamento da peça usinada e na vida da ferramenta de corte
Authors: Silva Amanda Beatriz Barbosa , Lima RamsésOtto Cunha
Published: July 2022

Na indústria metal-mecânicaéinteressante que exista um gerenciamento envolvendo sustentabilidade, produtividade e qualidade, considerando sempre queo produto final deve ter um padrão de qualidade aceitável.No que diz respeito ao processo de usinagem, os fluidos de corte hoje são essenciais, pois desempenham algumas funções consideradas indispensáveis. Além disso, deve-se dar a devida importância a grande quantidade de calor desenvolvida durante o corte, o qual,precisa ser reduzido. Nesse contexto, considera-se uma alternativa promissora,a redução da utilização de fluidos. Como consequência do que foi exposto, será realizado a usinagem do aço carbono ABNT 1045 utilizando insertos de metal duro comoferramenta, tendo como principal objetivo atender a uma exigência de rugosidade superficial eaos padrões básicos para esse tipo de operação.A partir disso, uma avaliação será feita de maneira a discutir qual dos três métodos de lubrificação é mais adequado:a seco, fluido abundante e MQF (Mínima Quantidade de Fluido) e em como adequar o uso do fluido de corte para verificar a influência desses recursos na vida da ferramenta e no acabamento da peça, sempre considerando que os parâmetros de corte utilizados serão fixos para os três processos.
Influência da composição dos moldes de fundição à base de gesso sobre as propriedades mecânicas e microestruturais da peça fundida em alumínio
Authors: Morais Arthur Domingos Mesquita de , Lima Ramsés Otto Cunha
Published: July 2022

De maneira a simplificar e baratear o processo de shell molding, sem deixar de obter suas vantagens, o gesso, com a adição de materiais refratários, é aplicado em substituição à areia. Assim, tem-se como propostaestudar a influência das proporções do material utilizado para confeccionar moldes feitos de uma mistura de gesso e cimento refratário sobre as propriedades mecânicas e microestruturaisda peça fundida. A peça fundida para os ensaios foi um corpo de prova de traçãosegundo a norma ASTM –E8, utilizando um molde com as dimensões 140x326x400 mm. Para a análise foi usada uma proporção, levando –se em conta a porcentagem segundo a massa do molde, inicialmente com 100% de gesso e 20% de cimento refratário e, posteriormente,com 80% de gesso e 20% de cimento refratário. Foi usado o alumínio 6063 emum forno com uma temperatura máxima de trabalho e temperatura de vazamento de 854 ºC e 750 ºC, respectivamente. Verificou-se um aumento da resistência e dureza nas peças dos moldes com o cimento refratário. Além disso, pela análise de microscopia, verificou-se uma redução no número de poros e microporos quando comparados às peças produzidas com o moldede 100% de gesso, em contrapartidaessas apresentaram uma qualidade superficial melhor.
Simulação de fluxo de carga para sistemas de transmissão e distribuição de energia elétrica como ATPDraw
Authors: Moura Adriano Aron F. de , Ferreira Pablo Fillype Teixeira , Aguiar Victor de Paula Brandão , Rocha Ednardo Pereira da , Paula João Frederico Souza de , Moura Ailson Pereira de
Published: July 2022

Nofluxo de carga, a obtenção do estado da operação de redes elétricas de potência, tem como base matemática métodos numéricos comoNewton-Raphsoncom as variações dos métodos desacoplado e desacoplado rápido. Dentre as principais ferramentas as quaisutilizam estes métodos numéricos, sãoprogramas de modelagem computacional. Mesmo que tais programas sejam ótimas ferramentas de análise, as demandas atuais precisam de programas velozes ede simplesmodelagem para os sistemas de transmissão/ distribuição e operação deredeselétricasde potência. A utilização do software ATPDrawdeve-se pela simplificação e praticidade com a construção de suas simulações baseadas nos métodos já consagrados no estudo de fluxo de carga, sendouma excelente ferramenta para tais estudos. O presente trabalho aborda amodelagem de um sistema de transmissão de duas barras, com barras PQ e PVedo sistema de distribuição IEEE de quatro barras.As simulações dos sistemas de duas barrase do sistema IEEE 4 barra permitiram observar as tensões elétricas nas barras do sistemaeos fluxos de potência nas linhas de transmissão e distribuição, comprovando aeficácia do ATPDraw na análise da rede elétrica em regime permanente.
Potencial de conservação de energia a partir do descarte de módulos fotovoltaicos no Brasil
Authors: Maia Antonio Gabriel Fernandes
Published: July 2022

Dentre as tecnologias existentes na produção dos módulos fotovoltaicos, existe o predomínio dos módulos de silício mono e policristalinos (c-Si). Estes possuem vida útil limitada em aproximadamente 25 anos, em condições normais. Por possuir metais pesados em sua composição, o descarte inadequado pode causar danos ao meio ambiente. Dentre as formas de descarte dos resíduos dos módulos c-Si, a reciclagem se destaca por permitir a recuperação de parte dos materiais, que não são renováveis, e reutilizá-los. A produção de certos materiais com o uso da reciclagem possibilita redução no consumo de energia elétrica, em comparação com a utilização de matéria prima. Diante disso, o presente trabalho visa estimar o potencial de energia elétrica conservável a partir da reciclagem dos módulosFV c-Si. Além disso é estimado o quanto de energia pode ser evitada com a reciclagem de módulos descartados no Brasil. Os resultados se mostraram satisfatórios e estima-se que cada módulo FV c-Si reciclado pode-se conservar algo em torno de 43 kWh.
Análise comparativa entre métodos numéricos e analíticos em circuitos transitórios
Authors: Farias Luiz Henrique Rodrigues , Silva Paulo Cesar Linhares da , Pinheiro Antônia Jocivania
Published: July 2022

Os métodos numéricos e analíticos são de suma importância na análise e modelagem de problemas na engenharia. Diante deste contexto, este trabalho visa realizar uma metodologia de estudo e ensino de circuitos elétricos clássicos. Tal metodologia baseia-se em um estudo analítico e numérico das equações diferenciais que envolvem os circuitos. A programação utilizada é feita na linguagem C/C++. A equação diferencial é resolvida de maneira analítica e comparada com as soluções numéricas do método de Runge Kutta de 4ª ordem (RK 4ª) e o método das séries de potência. Foi constatado ao final das soluções um erro percentual pequeno, o que mostra a precisão e aplicabilidade dos métodos numéricos empregados.
Estudo da interação entre nanoelementos magnéticos dispostos horizontalmente
Authors: Mota Thaysa Danielly Soares da , Queiroz Júnior Idalmir de Souza , Ferreira Marcos Vinícius de Mendonça
Published: July 2022

O presente trabalho desempenhouum estudo sobre a interação entre nanoelementos magnéticos acoplados paralelamente ao eixo x, alterando suas dimensões e espaçamento, apresentando resultados para sua aplicação na construção de portas lógicas magnéticas, utilizando os materiais Ferro, Cobalto, Níquel e Permalloy. O principal objetivo é encontrar, entre os materiais escolhidos para o trabalho, aquele que possua uma melhor resposta de reversão de sua magnetização, com base nas configurações adotadas e, com isso, mostrar graficamente uma faixa de valores favoráveis para um comportamento de alinhamento ferromagnético, ponto importante para sua aplicação em portas lógicas magnéticas. Obtendo assim um comparativo gráfico entre os elementos abordados, a fim de que se tenha aquele que se configure melhor a sua aplicação.Utilizando-se de um recurso computacional autoconsistente e traçando um perfil de configuração, para cada proporção utilizada, constrói-se uma máscara da disposição desses nanoelementos e após o seu processamento, esplana-se graficamente seus resultados com os valores obtidos. Concluindo assim, quais os materiais que conseguem, dentro das dimensões utilizadas, reverter sua magnetização e com isso conseguir um alinhamento ferromagnético, fornecendoa faixa de valores mais viáveis paraessa característica.
Gulf Asthma Diagnosis and Management in Adults: Expert Review and Recommendations
Authors: Al Busaidi Nasser , Alweqayyan Adnan , Al Zaabi Ashraf , Mahboub Bassam , Al-Huraish Fatma , Hameed Mansoor , Al-Ahmad Mona , Khadadah Mousa , Al Lawati Nabil , Behbehani Nasser , Al Jabri Omar , Salman Reyad , Al Mubaihsi Saif , Al Raisi Shadha
Published: July 2022

The prevalence and incidence of asthma are increasing globally because of genetic and environmental influences. Prevalence of asthma in the Gulf has been reported to range from 4.7% to 32.0% and has a substantial economic burden. In this paper, we summarize current asthma management guidance for adults, present insights, and recommendations by key opinion leaders (KOLs) in the Gulf region, and key performance indicators for guiding clinical practice for asthma diagnosis, management, and treatment in the Gulf. While it is recommended that the Global Initiative for Asthma (GINA) guidelines should be followed wherever possible for the management of asthma, KOLs in the Gulf region have presented additional recommendations based on regional challenges and insights. There is a need for better diagnosis using objective testing, increased efforts in tackling the burden of comorbidities in the region, and greater provision of the necessary tools for phenotyping severe asthma. Furthermore, there is a need for greater education for physicians regarding asthma treatment, including the importance of inhaled-corticosteroid-containing controller medication. Regionally, there is also a need for specialist asthma clinics and asthma educators, which would serve to educate physicians and their patients as well as to improve the management of patients. Finally, the use of asthma registries, digital devices, and electronic templates would be of benefit in the management of asthma patients in the region.
Cellular and Molecular Mechanisms of Breast Cancer Progression
Authors: Verma Ajeet Kumar , Mishra Sanjay , Mina Puja Rani , Misri Swati
Published: July 2022

Breast cancer is a common death-related cancer in women globally. Early and non-metastatic stage breast cancers are curable in 70-80% of the patients, while advanced-stage distant organ metastatic breast cancers are incurable with present treatment options. Although multiple risk factors are associated with breast cancer, among them, genetic predispositions in BRCA1 and BRCA2 genes are the most causative factor for breast cancer malignancy. The initiation and progression of breast cancer is a multi-step process, which can initiate either in ducts or lobules of the breast tissues. As time progresses pre-invasive lesions form of breast neoplasm transforms into atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS)/lobular carcinoma in situ (LCIS), and eventually become invasive carcinoma. The molecular mechanisms behind the initiation and progression of breast cancer are not completely understood. However, epithelial-mesenchymal transition (EMT) is the assurance of malignancy which disrupts endothelial integrity and therefore, it increases the spreading of cancer cells and facilitates metastasis. After the epithelial-mesenchymal transition of tumor cells, tumor cells invade and migrate the neighboring as well as distant tissues, cross the endothelial barrier and enter the blood, and attach to a secondary site, forming metastases. In this chapter, we have reviewed an overview of the molecular mechanisms of breast cancer progression.
Autoantibodies as Clinical Biomarkers in Breast Cancer
Authors: Gupta Prachi
Published: July 2022

Breast cancer (BC) is one of the most diagnosed and worldwide
malignancies in females with an estimated 1,300,000 new cases and 465,000 deaths
annually. Therefore, early diagnosis and effective treatments of BC are urgently needed
in the struggle against this disease. Molecular markers research has gained huge
momentum in BC management. Very few molecular markers are in clinical use for BC
management. However, owing to BC heterogeneity, more molecular markers are
required for better diagnosis and treatment. Humoral immune response defines the
generation of autoantibodies (AAbs) in blood against tumor-associated antigens
(TAAs). Such AAbs have been showing great promises for biomarker development for
cancer detection. Therefore, these candidate AAbs might be useful for developing
blood-based detection assays along with other existing diagnostic tools for BC patients.
Besides that, AAbs can also assist in the identification of novel TAAs that can further
enhance the utility of immuno-proteomics for biomarkers development and targeted
therapy. In this scenario, proteomics tools are being extensively utilized to identify
novel TAAs.