bluuebunny/crossref_metadata_2025 huggingface dataset:
Chinese Patent Medicine Shufeng Jiedu Capsules as an Adjuvant Therapy for Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Zhang Xiao-Wen , Xia Ru-Yu , Gao Jia-Qi , Liu Jin-Jun , Xu De-Hao , Li Xun , Hu Xiao-Yang , Willcox Merlin , Moore Michael , Dai Meng-Yuan , Trill Jeanne , Fei Yu-Tong , Liu Jian-Ping
Published: July 2022

Background: Shufeng Jiedu (SFJD) capsules can be used as adjunctive treatment for patients with community-acquired pneumonia, but the effectiveness and safety of SFJD are not clear. This review aims to evaluate the effectiveness and safety of SFJD based on randomized controlled trials (RCTs).

Methods: A systematic review was conducted by searching PubMed, Embase, Scopus, Web of Science, CENTRAL, CNKI, VIP, CBM, Wanfang and trial registry platforms from their inception to March 2022. Two reviewers screened studies, extracted the data and assessed risk of bias independently. The data were pooled for meta-analysis or presented narratively.

Results: Seventeen RCTs involving 1840 participants were included. All trials compared SFJD plus antibiotics to antibiotics, or combined with symptomatic treatment in both groups. The overall certainty of evidence was assessed as moderate to very low certainty. Compared with routine treatment (antibiotics alone or antibiotics plus symptomatic treatment), SFJD plus routine treatment showed beneficial effects in resolution of fever (MD −1.20 days, 95%CI −1.73 to −0.67; 10 RCTs; very low certainty), cough (MD −1.02 days, 95%CI −1.23 to −0.81; 9 RCTs; moderate certainty), phlegm (MD −1.46 days, 95%CI −2.84 to −0.08; 6 RCTs; very low certainty), pulmonary crepitations (MD −1.61 days, 95%CI −2.64 to −0.59; 8 RCTs; low certainty), shortness of breath (MD −2.80 days, 95%CI −2.88 to −2.72; 2 RCTs; low certainty) and chest pain (MD −2.85 days, 95%CI −3.01 to −2.69; 1 RCT; low certainty). There was no significant difference in pathogen clearance (1 RCT). No serious adverse events were reported, but 2.60% (5/192) patients reported nausea in the SFJD groups, 1.04% (2/192) participants in routine group, and no significant difference was identified.

Conclusions: Current evidence suggests that adding SFJD may shorten the duration of symptom relief in community-acquired pneumonia for 1–2 days. The adverse events were minor and controllable, and no serious adverse events were reported. Well-reported trials and potential of reducing antibiotics were expected in the future studies.
Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy
Authors: Zhou Jiao , Chen Honghan , Du Jintao , Tai Haoran , Han Xiaojuan , Huang Ning , Wang Xiaobo , Gong Hui , Yang Mingyao , Xiao Hengyi
Published: July 2022

Glutamine is a conditionally essential amino acid involved in energy production and redox homeostasis. Aging is commonly characterized by energy generation reduction and redox homeostasis dysfunction. Various aging-related diseases have been reported to be accompanied by glutamine exhaustion. Glutamine supplementation has been used as a nutritional therapy for patients and the elderly, although the mechanism by which glutamine availability affects aging remains elusive. Here, we show that chronic glutamine deprivation induces senescence in fibroblasts and aging in Drosophila melanogaster, while glutamine supplementation protects against oxidative stress-induced cellular senescence and rescues the D-galactose-prompted progeria phenotype in mice. Intriguingly, we found that long-term glutamine deprivation activates the Akt-mTOR pathway, together with the suppression of autolysosome function. However, the inhibition of the Akt-mTOR pathway effectively rescued the autophagy impairment and cellular senescence caused by glutamine deprivation. Collectively, our study demonstrates a novel interplay between glutamine availability and the aging process. Mechanistically, long-term glutamine deprivation could evoke mammalian target of rapamycin (mTOR) pathway activation and autophagy impairment. These findings provide new insights into the connection between glutamine availability and the aging process.
Pharmacokinetic Study of Four Major Bioactive Components of Liandan Xiaoyan Formula in Ulcerative Colitis and Control Rats Using UPLC-MS/MS
Authors: Zhang Kaihui , Lu Zenghui , Wang Qian , Liu Fangle , Wang Meiqi , Lin Chaozhan , Zhu Chenchen
Published: July 2022

Liandan Xiaoyan Formula (LXF), a classic Traditional Chinese medicine (TCM) formula, is composed of two Chinese herbal medicines for treating bowel disease under the TCM theory. This study aimed to develop a rapid, stable, sensitive, and reliable method based on ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to simultaneously determine four major bioactive components of LXF (andrographolide, dehydroandrographolide, 1-methoxicabony-β-carboline, 4-methoxy-5-hydroxy-canthin-6-one) in rat serum and evaluate the pharmacokinetic characteristics of LXF in ulcerative colitis (UC) and control rats. After pretreating by protein precipitation with methanol, separation was performed on a UPLC C18 column using gradient elution with a mobile phase consisting of acetonitrile and 0.1% formic acid at a flowing rate of 0.4 ml/min. Detection was performed on Triple-TOF™ 5600 mass spectrometry set at the positive ionization and multiple reaction monitoring (MRM) mode. The validated method showed good linearity (R2 ≥ 0.9970), the intra- and inter-day accuracy were within ±11.58%, whereas the intra- and inter-day precision were less than 13.79%. This method was validated and applied to compare the pharmacokinetic profiles of the analytes in serum of UC induced by dextran sulphate sodium (DSS) and control rats after oral administration of LXF. The results showed that four major bioactive components of LXF were quickly absorbed after oral administration in both groups, with higher exposure levels in the UC group. This relationship between the active ingredients’ pharmacokinetic properties provided essential scientific information for applying LXF in clinical.
Multiscale Optical Modeling of Perovskite-Si Tandem Solar Cells
Authors: Hägglund Carl
Published: July 2022

With the success of silicon (Si) solar cell technology, research and development on higher efficiency multijunction solar cells is gaining much attention. Tandem cells with a perovskite top cell and a Si bottom cell show particular potential. However, the optical modeling of such devices is complicated by the broad range of length scales involved; the optically thin layers and nanoscale features of a perovskite solar cell require some version of wave optics or even full field electromagnetic (EM) calculations, while the micrometer scale structuring and large dimensions of Si cells are much more manageable using geometrical (ray) optics. In the present work, a method for combining EM and ray optical calculations is developed and described in detail, with examples provided in the software Comsol Multiphysics. For regions with thin films or nanoscale features, EM wave calculations are performed using the finite element method. These calculations provide the phase and amplitude of the waves diffracted into different orders, of which only the regular reflection and transmission are typically of relevance for nanoscale periodicity. In the ray optics simulation, the corresponding regions are implemented as diffracting interfaces, with deterministic transformations of the Stokes vector components according to the EM wave calculations. Meanwhile, the absorbed intensity of intersecting rays is recorded. The method is applied to separate perovskite and Si solar cells and to a few tandem solar cells of relevance for two- versus four-terminal configurations. Corrections for strongly absorbing media in the ray tracing algorithm, which use generalized versions of the Fresnel coefficients, Snell’s law and the Beer-Lambert law, are also evaluated. In a typical Si solar cell with a front surface structure of inverted pyramids, such corrections are found to reduce the absorption by up to 0.5 percentage units compared to a conventional ray tracing calculation. The difference is concluded to originate mainly from reduced absorption rates of inhomogeneous waves, rather than from enhanced escape probabilities for (quasi-) trapped rays at the Si front surface. The method is further applied to evaluate the effects of a plasmonic nanoparticle array, embedded in a perovskite solar cell stack that is located directly on the microstructured Si surface.
Optimal Resonances in Multiplex Neural Networks Driven by an STDP Learning Rule
Authors: Yamakou Marius E. , Tran Tat Dat , Jost Jürgen
Published: July 2022

In this paper, we numerically investigate two distinct phenomena, coherence resonance (CR) and self-induced stochastic resonance (SISR), in multiplex neural networks in the presence of spike-timing-dependent plasticity (STDP). The high degree of CR achieved in one layer network turns out to be more robust than that of SISR against variations in the network topology and the STDP parameters. This behavior is the opposite of the one presented by Yamakou and Jost (Phys. Rev. E 100, 022313, 2019), where SISR is more robust than CR against variations in the network parameters but in the absence of STDP. Moreover, the degree of SISR in one layer network increases with a decreasing (increasing) depression temporal window (potentiation adjusting rate) of STDP. However, the poor degree of SISR in one layer network can be significantly enhanced by multiplexing this layer with another one exhibiting a high degree of CR or SISR and suitable inter-layer STDP parameter values. In addition, for all inter-layer STDP parameter values, the enhancement strategy of SISR based on the occurrence of SISR outperforms the one based on CR. Finally, the optimal enhancement strategy of SISR based on the occurrence of SISR (CR) occurs via long-term potentiation (long-term depression) of the inter-layer synaptic weights.
Recent Advances in Chirally-Coupled Core Fibers
Authors: Yuan Mingheng , Sui Yuan , Bai Zhenao , Fan Zhongwei
Published: July 2022

To meet the needs of high-power fiber lasers, a new fiber structure called chirally coupled core (CCC) fiber has attracted the attention of researchers all over the world. CCC fiber consists of two cores, one of which is a central core distributed along the axial direction, and the other is a side core that is offset from the central axis and spirally distributed around the central core. Meanwhile, CCC fibers are helical-translation symmetric. The unique structure results in advantages of robust single-mode performance, mode-distortion-free splicing and compact coiling of CCC fiber. Based on a brief description of the theory about CCC fiber, this article focuses on the research progress and application prospect of CCC fiber.
RsGSTF12 Contributes to Anthocyanin Sequestration in Radish (Raphanus sativus L.)
Authors: Niu Mengyang , Bao Changjian , Chen Jiahui , Zhou Wen , Zhang Yueyue , Zhang Xiaoyan , Su Nana , Cui Jin
Published: July 2022

Anthocyanins are water-soluble plant pigments mainly stored in the plant vacuoles. Glutathione S-transferases (GSTs) are a multifunctional enzyme family, which can regulate substance metabolism and biological and abiotic stresses in plants. However, few reports were focused on the involvement of GSTs in anthocyanin sequestration in red skin radish. Here, we identified a glutathione S-transferase gene RsGSTF12 that played roles in anthocyanin sequestration in radish. The bioinformatics analysis revealed that RsGSTF12 belonged to the phi (F) class of glutathione S-transferases and showed a high homology with AtGSTF12, followed by AtGSTF11. The subcellular localization assay showed that RsGSTF12 was located in the endoplasmic reticulum and tonoplast. Temporal and spatial gene expression-specific analyses uncovered a strong correlation of RsGSTF12 with anthocyanin accumulation in radish sprouts. The anthocyanin solubility assay found RsGSTF12 was capable of improving cyanidin water solubility in vitro. Transiently expressing RsGSTF12 in radish cotyledons was able to increase their anthocyanin sequestrations. Furthermore, the functional complementation and overexpression of the Arabidopsis thaliana tt19 mutant and wild type demonstrated that RsGSTF12 might play an indispensable role in anthocyanin accumulation in radish. Taken together, we provide compelling evidence that RsGSTF12 functions critically in how anthocyanins are sequestrated in radish, which may enrich our understanding of the mechanism of anthocyanin sequestration.
Plant Foraging Strategies Driven by Distinct Genetic Modules: Cross-Ecosystem Transcriptomics Approach
Authors: Sugimura Yusaku , Kawahara Ai , Maruyama Hayato , Ezawa Tatsuhiro
Published: July 2022

Plants have evolved diverse strategies for foraging, e.g., mycorrhizae, modification of root system architecture, and secretion of phosphatase. Despite extensive molecular/physiological studies on individual strategies under laboratory/greenhouse conditions, there is little information about how plants orchestrate these strategies in the field. We hypothesized that individual strategies are independently driven by corresponding genetic modules in response to deficiency/unbalance in nutrients. Roots colonized by mycorrhizal fungi, leaves, and root-zone soils were collected from 251 maize plants grown across the United States Corn Belt and Japan, which provided a large gradient of soil characteristics/agricultural practice and thus gene expression for foraging. RNA was extracted from the roots, sequenced, and subjected to gene coexpression network analysis. Nineteen genetic modules were defined and functionally characterized, from which three genetic modules, mycorrhiza formation, phosphate starvation response (PSR), and root development, were selected as those directly involved in foraging. The mycorrhizal module consists of genes responsible for mycorrhiza formation and was upregulated by both phosphorus and nitrogen deficiencies. The PSR module that consists of genes encoding phosphate transporter, secreted acid phosphatase, and enzymes involved in internal-phosphate recycling was regulated independent of the mycorrhizal module and strongly upregulated by phosphorus deficiency relative to nitrogen. The root development module that consists of regulatory genes for root development and cellulose biogenesis was upregulated by phosphorus and nitrogen enrichment. The expression of this module was negatively correlated with that of the mycorrhizal module, suggesting that root development is intrinsically an opposite strategy of mycorrhizae. Our approach provides new insights into understanding plant foraging strategies in complex environments at the molecular level.
Sulfur Enhancement for the Improvement of Castor Bean Growth and Yield, and Sustainable Biodiesel Production
Authors: Mukhtar Ahmed , Awan Masood Iqbal , Sadaf Sana , Mahmood Athar , Javed Talha , Shah Adnan Noor , Shabbir Rubab , Alotaibi Saqer S. , Shah Anis Ali , Adamski Robert , Siuta Dorota
Published: July 2022

Due to limited conventional energy sources, there is a need to find substitute non-conventional sources of energy to meet the societal demands on a sustainable basis. Crude oil and edible oil remain major import items in Pakistan, the deficit of which can be compensated by using biomass, preferably inedible oilseeds. Therefore, the current study evaluated the role of sulfur (S) fertilization for improving yield (seed and oil) and biodiesel value of castor bean, a potential inedible crop with minimum input requirements. For this purpose, a combined approach of field experimentation and laboratory analysis was conducted to explore the potential of two castor bean cultivars (DS-30 and NIAB Gold) against four S supply rates, namely, 0, 20, 40, and 60 kg S ha–1, in terms of growth, phenology, and yield parameters. Subsequently, the obtained seed samples were analyzed for biodiesel-related parameters in the Bio-analytical Chemistry lab, Punjab Bio-energy Institute, Faisalabad. The incremental S rates increased the seed yield for both cultivars, and the highest yield was recorded at 60 kg S ha–1 for NIAB Gold. For NIAB Gold, the oil content increased by 7% with S fertilization at 60 kg ha–1, and for DS-30, the oil content increased by 6% at 60 kg ha–1. As with incremental S fertilization, the oil yield increased on a hectare basis, and the quantity of biodiesel produced also increased. Importantly, the tested quality parameters of biodiesel, except biodiesel viscosity, were in the ASTM standard range. Overall, it has been concluded that castor bean is a promising and sustainable option for producing biodiesel as it is non-competitive to food crops and requires little input.
The GmSNAP11 Contributes to Resistance to Soybean Cyst Nematode Race 4 in Glycine max
Authors: Shaibu Abdulwahab S. , Zhang Shengrui , Ma Junkui , Feng Yue , Huai Yuanyuan , Qi Jie , Li Jing , Abdelghany Ahmed M. , Azam Muhammad , Htway Honey Thet Paing , Sun Junming , Li Bin
Published: July 2022

Soybean cyst nematode (SCN) has devastating effects on soybean production, making it crucial to identify genes conferring SCN resistance. Here we employed next-generation sequencing-based bulked segregant analysis (BSA) to discover genomic regions, candidate genes, and diagnostic markers for resistance to SCN race 4 (SCN4) in soybean. Phenotypic analysis revealed highly significant differences among the reactions of 145 recombinant inbred lines (RILs) to SCN4. In combination with euclidean distance (ED) and Δsingle-nucleotide polymorphism (SNP)-index analyses, we identified a genomic region on Gm11 (designated as rhg1-paralog) associated with SCN4 resistance. Overexpression and RNA interference analyzes of the two candidate genes identified in this region (GmPLAC8 and GmSNAP11) revealed that only GmSNAP11 significantly contributes to SCN4 resistance. We developed a diagnostic marker for GmSNAP11. Using this marker, together with previously developed markers for SCN-resistant loci, rhg1 and Rhg4, we evaluated the relationship between genotypes and SCN4 resistance in 145 RILs and 30 soybean accessions. The results showed that all the SCN4-resistant lines harbored all the three loci, however, some lines harboring the three loci were still susceptible to SCN4. This suggests that these three loci are necessary for the resistance to SCN4, but they alone cannot confer full resistance. The GmSNAP11 and the diagnostic markers developed could be used in genomic-assisted breeding to develop soybean varieties with increased resistance to SCN4.
Effects of Vegetation Phenology on Ecosystem Water Use Efficiency in a Semiarid Region of Northern China
Authors: Zhang Yaru , Zhang Jing , Xia Jianyang , Guo Yahui , Fu Yongshuo H.
Published: July 2022

Water use efficiency (WUE) is an important ecosystem functional property for measuring coupled relationships of the carbon-water cycle. Both biotic and environmental factors significantly impact WUE in terrestrial ecosystems. Relationships between environmental factors and WUE have been well discussed in previous studies. Although the crucial role of vegetation phenology, a common indicator of climate-vegetation interactions, in regulating the WUE has been widely reported, the underlying mechanism has not yet to be fully elucidated. Here, we utilized multiple long-term remote sensing datasets to analyze the interannual changes in seasonal WUE, and discussed the potential associations between phenology and WUE in the Luanhe River basin, which is a typical semiarid region of China, from 1988 to 2015. Most of the pixels across Luanhe River basin showed increasing spring WUE and decreasing autumn WUE. The start of the growing season (SOS) was slightly advanced by an average of 0.06 days per year (d/y) in the whole study area, with a delayed trend (0.04 d/y) in the upper reaches region (UR) and an advanced trend (0.20 d/y) in the middle-lower reaches region (MLR). The end of the growing season (EOS) showed a generally delayed trend (0.11 d/y) across the basin. Furthermore, negative correlations were detected between spring WUE and SOS in the UR, while positive correlations were detected in the MLR. The opposite patterns of the relationship of autumn WUE and EOS were also found between UR and MLR. The results were attributed to the balance and compensation of biotic and abiotic factors in the regulation of ecosystem WUE. Our findings provide new insights into the interaction between vegetation dynamics and carbon-water cycle coupling.
Appraisal Bias and Emotion Dispositions Are Risk Factors for Depression and Generalized Anxiety: Empirical Evidence
Authors: Scherer Klaus R. , Costa Marco , Ricci-Bitti Pio , Ryser Valérie-Anne
Published: July 2022

Appraisal theory of emotion predicts that appraisal biases may generate stable emotion dispositions, which can ultimately lead to affective disorders. One example is the habitual underestimation of one’s potential to cope with adverse events, which favors frequent experiences of sadness and worry and therefore increases the risk for development of depression and generalized anxiety disorders. To examine the relationships between these variables as potential risk factors, in Study 1, we used appraisal and emotion questions in the Swiss Household Panel (SHP), a nationwide representative sample, and analyzed data forN = 4,859 participants in one annual survey wave (Wave 14, SHP 2012)viatheory-based hierarchical regressions. Path analysis of the nomological network linking frequent experiences of depression and anxiety to the emotion dispositions of sadness and worry, and measures of perceived coping potential (appraisal bias) supports the theoretical predictions and further identifies the effects of important background variables such as personality, motivation, and life events. Discriminant analysis shows that these predictors allow correct classification of close to 70% of the participants with elevated risk. In Study 2, we used established validated instruments to assess the risk for depression and anxiety disorders, as well as a recently validated scenario method to assess appraisal bias and emotion disposition in a survey withN= 152 students. The results correspond to the theoretical predictions and largely confirm the findings with the household survey. The results of both studies demonstrate the utility of using current emotion theory to provide new vistas for research on risk factors for affective disorders and to inform the development of appropriate interventions to reduce the level of risk.
Clinical and Functional Differences Between Mexican Youth at Clinical High Risk for Psychosis and With Familial High Risk
Authors: Nieto Lourdes , Domínguez-Martínez Tecelli , Rosel-Vales Mauricio , Saracco-Alvarez Ricardo , Celada-Borja Cesar , Rascón-Gasca María Luisa
Published: July 2022

Few studies have explored the differences in clinical psychopathology between youth at high risk for psychosis and those at familial high risk for psychosis. This study seeks to describe and compare the sociodemographic, clinical, and functional characteristics of At-Risk Mental State (ARMS) for psychosis youth and those with a first- or second-degree relative with psychosis (Familial High-Risk: FHR) in a Mexican sample. Twenty-one ARMS individuals and 21 with FHR were evaluated for sociodemographic characteristics, psychopathological symptoms, and functional impairment. ARMS individuals were significantly younger, had fewer years of schooling, and were more likely to be male than those in the FHR group. Groups did not differ as regards marital status or occupation. The ARMS group showed greater severity of prodromal symptoms, schizotypal personality traits, and general psychopathology than the FHR group. In addition, they reported more premorbid adjustment deficit from early adolescence than the FHR group. Current overall social and role functioning was significantly lower in the ARMS group. Findings are consistent with ARMS studies from other countries. First- or second-degree relatives of patients with psychosis should be considered a vulnerable group as they display several symptoms of general psychopathology and may experience social adjustment problems in their adult lives. The lack of early detection and intervention psychosis programs in Mexico underlines the need to prioritize the development of preventive strategies to help close the care gap.
Understanding Family Tourism: A Perspective of Bibliometric Review
Authors: Qiao Guanghui , Cao Yating , Chen Qingwen , Jia Qiaoran
Published: July 2022

The study performed bibliometric visual analyses of family tourism research literature from 2008 to 2021, revealing the knowledge evolution process, research focuses, and future trends in this field. A total of 132 articles on family tourism were collated from the SSCI database of the Web of Sciences core collection and analyzed by CiteSpace. The results show that the number of research studies on family tourism has increased from 2008 to 2021, however, the overall base is small. Purdue University has the highest number of publications and citations. Inter-country cooperation occurs between the United States, China, the United Kingdom, and Australia. Recently, “motivation” and “benefit” have become hot topics in family tourism research, and “social tourism” has received widespread attention, revealing future research directions. Lehto and Wu are the core figures in the family tourism field, and their achievements have been highly cited and peer-recognized. This study focuses on family tourism research in different cultural situations, enriching the knowledge system of family tourism research, and encouraging future family tourism research focus more on seniors and disadvantaged families.
The Impact of Corporate Social Responsibility on Sustainable Innovation: A Case in China’s Heavy Pollution Industry
Authors: Yan Rui , Li Xiaolin , Zhu Xiaoning
Published: July 2022

Exploring the impact of corporate social responsibility (CSR) fulfillment and disclosure on enterprises’ sustainable innovation capacity can not only expand the research boundary of factors of sustainable innovation and the impact of CSR, but it can also serve as a reference for the decision-making of listed companies in increasing pollution problems. Using a sample of 224 Chinese A-share businesses in the heavy pollution industry listed between 2016 and 2020 and employing an ordinary least square regression, the results provide empirical evidence that CSR is positively associated with sustainable innovation. Second, the business environment can serve as a moderator of the relationship between CSR and sustainable innovation, and the positive relationship between CSR and sustainable innovation is more pronounced in regions with better macroeconomic conditions. Additionally, the improvement of CSR for sustainable innovation is more clear in state-owned firms than in non-state-owned enterprises. After a series of robustness tests that eliminate marketization, law enforcement, and macro-political unpredictability, the results still hold. This study broadens the scope of CSR and sustainable innovation research. In addition, the theoretical and practical significance of this study’s findings is referenced in this paper.
Reduction of Orexin-A Is Associated With Anxiety and the Level of Depression of Male Methamphetamine Users During the Initial Withdrawal Period
Authors: Guo Lei , Hu Aqian , Zhao Xiaoxi , Xiang Xiaojun
Published: July 2022

Background

Orexin has been linked to the regulation of reward and motivation in animals, but there have been few human studies to validate its regulatory effects. We aimed to determine how orexin-A levels changed during different stages of withdrawal, as well as the relationship between orexin-A levels and withdrawal symptoms in male METH users.

Methods

This study included 76 METH users and 35 control participants. The METH users were divided into three groups: group 1 (abstinence within 1 week, n = 23), group 2 (abstinence between 1 week and 3 months, n = 38), and group 3 (abstinence over 3 months, n = 15). At baseline and 1 month of enrollment, the plasma orexin-A level was examined. To track the withdrawal symptoms, self-report questionnaires (anxiety, depression, craving, and sleep quality) were collected at two points.

Results

The orexin-A levels of groups 1 (p < 0.001) and 2 (p < 0.001) were lower than that of the controls at baseline but not group 3. One month later, the orexin-A levels of group 2 (p < 0.05) significantly increased, while no significant changes in those of groups 1 and 3 were observed. Furthermore, the orexin-A levels of group 1 were positively linked with depression (p < 0.01) and anxiety (p < 0.01) at baseline.

Conclusions

The decrease in orexin-A levels was only transitory during the initial abstinence phase, and it was eventually restored near to normal with continued abstinence among the male METH users. Furthermore, a lower concentration of orexin-A may serve as a risk factor for negative emotions during METH withdrawal.
Fear of Recurrence of Atrial Fibrillation: Translating a Cancer Fear Model to the Atrial Fibrillation Patient Experience
Authors: Anthony Scarlett , Harrell Rebecca , Martin Caroline , Hawkins Taylor , Khan Saleen , Naniwadekar Aditi , Sears Samuel F.
Published: July 2022

Background

Atrial fibrillation occurs when rapid and disorganized electrical signals cause the atria in the heart to beat irregularly and is associated with an increased risk for stroke. Despite medical advancements, first and second line atrial fibrillation treatments exhibit significant recurrence rates. Because of this, atrial fibrillation patients often experience disease-specific fears that are not routinely assessed and targeted in clinical management. Fear of recurrence models in cancer research and other cardiac-specific fears have paved the way for a patient-centric approach to disease intervention.

Purpose

Clinical assessment focused solely on the taxonomy of anxiety disorders may miss key components unique to the atrial fibrillation patient experience. An anxiety disorder diagnosis in the presence of an arrhythmia could be misleading and ultimately fail to address patient needs. Modeled from the cancer literature, providers may benefit from a broader disease specific conceptualization for AF patients that differs from a general DSM-5 diagnosis.

Aims

The objectives of this paper are: (1) to review the medical aspects of atrial fibrillation, (2) to examine the comparability of fear of recurrence concept from cancer literature to the atrial fibrillation patient, and (3) to suggest considerations of these novel concepts in patient care.

Future Directions

Increased understanding of fear of recurrence among atrial fibrillation patients aims to define and assess fear of recurrence components, determine treatment targets, and ultimately improve patient outcomes.
Gray Matter Network Associated With Attention in Children With Attention Deficit Hyperactivity Disorder
Authors: Wang Xing-Ke , Wang Xiu-Qin , Yang Xue , Yuan Li-Xia
Published: July 2022

Background

Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent childhood-onset neurodevelopmental disorders; however, the underlying neural mechanisms for the inattention symptom remain elusive for children with ADHD. At present, the majority of studies have analyzed the structural MRI (sMRI) with the univariate method, which fails to demonstrate the interregional covarying relationship of gray matter (GM) volumes among brain regions. The scaled subprofile model of principal component analysis (SSM-PCA) is a multivariate method, which can detect more robust brain-behavioral phenotype association compared to the univariate analysis method. This study aims to identify the GM network associated with attention in children with ADHD by applying SSM-PCA to the sMRI.

Methods

The sMRI of 209 children with ADHD and 209 typically developing controls (TDCs) aged 7–14 years from the ADHD-200 dataset was used for anatomical computation, and the GM volume in each brain region was acquired. Then, SSM-PCA was applied to the GM volumes of all the subjects to capture the GM network of children with ADHD (i.e., ADHD-related pattern). The relationship between the expression of ADHD-related pattern and inattention symptom was further investigated. Finally, the influence of sample size on the analysis of this study was explored.

Results

The ADHD-related pattern mainly included putamen, pallium, caudate, thalamus, right accumbens, superior/middle/inferior frontal cortex, superior occipital cortex, superior parietal cortex, and left middle occipital cortex. In addition, the expression of the ADHD-related pattern was related to inattention scores measured by the Conners’ Parent Rating Scale long version (CPRS-LV; r = 0.25, p = 0.0004) and the DuPaul ADHD Rating Scale IV (ADHD-RS; r = 0.18, p = 0.03). Finally, we found that when the sample size was 252, the results of ADHD-related pattern were relatively reliable. Similarly, the sample size needed to be 162 when exploring the relationship between ADHD-related pattern and behavioral indicator measured by CPRS-LV.

Conclusion

We captured a GM network associated with attention in children with ADHD, which is different from that in adolescents and adults with ADHD. Our findings may shed light on the diverse neural mechanisms of inattention and provide treatment targets for children with ADHD.
A Comparison Between Single- and Multi-Scale Approaches for Classification of Histopathology Images
Authors: D'Amato Marina , Szostak Przemysław , Torben-Nielsen Benjamin
Published: July 2022

Whole slide images (WSIs) are digitized histopathology images. WSIs are stored in a pyramidal data structure that contains the same images at multiple magnification levels. In digital pathology, most algorithmic approaches to analyze WSIs use a single magnification level. However, images at different magnification levels may reveal relevant and distinct properties in the image, such as global context or detailed spatial arrangement. Given their high resolution, WSIs cannot be processed as a whole and are broken down into smaller pieces called tiles. Then, a prediction at the tile-level is made for each tile in the larger image. As many classification problems require a prediction at a slide-level, there exist common strategies to integrate the tile-level insights into a slide-level prediction. We explore two approaches to tackle this problem, namely a multiple instance learning framework and a representation learning algorithm (the so-called “barcode approach”) based on clustering. In this work, we apply both approaches in a single- and multi-scale setting and compare the results in a multi-label histopathology classification task to show the promises and pitfalls of multi-scale analysis. Our work shows a consistent improvement in performance of the multi-scale models over single-scale ones. Using multiple instance learning and the barcode approach we achieved a 0.06 and 0.06 improvement in F1 score, respectively, highlighting the importance of combining multiple scales to integrate contextual and detailed information.
Comparing Deep Learning Approaches for Understanding Genotype × Phenotype Interactions in Biomass Sorghum
Authors: Zhang Zeyu , Pope Madison , Shakoor Nadia , Pless Robert , Mockler Todd C. , Stylianou Abby
Published: July 2022

We explore the use of deep convolutional neural networks (CNNs) trained on overhead imagery of biomass sorghum to ascertain the relationship between single nucleotide polymorphisms (SNPs), or groups of related SNPs, and the phenotypes they control. We consider both CNNs trained explicitly on the classification task of predicting whether an image shows a plant with a reference or alternate version of various SNPs as well as CNNs trained to create data-driven features based on learning features so that images from the same plot are more similar than images from different plots, and then using the features this network learns for genetic marker classification. We characterize how efficient both approaches are at predicting the presence or absence of a genetic markers, and visualize what parts of the images are most important for those predictions. We find that the data-driven approaches give somewhat higher prediction performance, but have visualizations that are harder to interpret; and we give suggestions of potential future machine learning research and discuss the possibilities of using this approach to uncover unknown genotype × phenotype relationships.
Levelling the Playing Field: The Role of Workshops to Explore How People With Parkinson's Use Music for Mood and Movement Management as Part of a Patient and Public Involvement Strategy
Authors: Rose Dawn C. , Poliakoff Ellen , Hadley Rebecca , Guérin Ségolène M. R. , Phillips Michelle , Young William R.
Published: July 2022

From a humanistic perspective, participatory processes in research find support on both ethical and moral grounds. In practical terms however, it is often difficult to establish protocols that best honour (i.e., elicit, capture, and integrate) the opinions of individuals and groups that represent the various specific stakeholders (e.g., from allied health, scientific, and academic disciplines) needed to investigate complex phenomena. Here, we describe a consultation process (funded by Parkinson's UK) devised to explore use of music among people with Parkinson's in relation to potential applications to enhance quality of life. People with Parkinson's were paired with researchers in order to discuss music on an equal footing so as to enable participant empowerment. We describe outcomes that demonstrate avenues of success as a result of this approach and additional insights gained through these processes in the hope of informing future practise. It has been our experience that researchers must establish a balance between (a) ensuring methodological rigour within an appropriate framework, and (b) facilitating informal “playtime” that develops connectivity between participants and enables both creative thinking and reflexive practise amongst stakeholders. We encourage researchers not to underestimate “playtime” as an important vehicle to foster this social interactivity and fuel the good will required to conduct inclusive and relevant research.
Why we Should Rethink Our Approach to Embodiment and Presence
Authors: Forster Pierre-Pascal , Karimpur Harun , Fiehler Katja
Published: July 2022

When interacting with objects in the environment, it feels natural to have a body which moves in accordance to our intentions. Virtual reality (VR) provides a tool to present users with an alternative virtual body and environment. In VR, humans embody the presented virtual body and feel present in the virtual environment. Thus, embodiment and presence frequently co-occur and share some communalities. Nevertheless, both processes have been hardly considered together. Here, we review the current literature on embodiment and presence and present a new conceptual framework, the Implied Body Framework (IBF), which unifies both processes into one single construct. The IBF can be used to generate new hypotheses to further improve the theoretical conceptualisation of embodiment and presence and thus, facilitate its transfer into application.
Efficacy of Riparian Buffers in Phosphorus Removal: A Meta-Analysis
Authors: Tsai Yushiou , Zabronsky Hope M. , Zia Asim , Beckage Brian
Published: July 2022

Efficacious use of riparian buffers (RBs) is a mitigation strategy that can protect water quality in the face of climate change and agricultural intensification. We investigated the efficacy of RBs in reducing phosphorus (P) and identified effective RB designs using two quantitative meta-analytic approaches, i.e., traditional random-effects meta-analysis and Bayesian mixed-effects regression, to synthesize the results from 36 peer-reviewed articles. We found that the overall P removal efficacy of RBs is 54.5% with a 95% confidence interval (46.1, 61.6), as indicated by our traditional meta-analysis, and 51.3% on average with a 95% confidence level (19.6, 71.2), as estimated by our Bayesian meta-analysis. The effectiveness of RBs was reduced by soil that was either bare, water-saturated, or covered by snowmelt. The interactive effect of width and slope on P removal in RBs varied considerably across different soils, leading to a larger variation in P removal efficacy, as compared to other studies. Our results show that width is the predominant determinant for P retention efficiency in clay soil RBs, whereas in sandy soil RBs, slope is the leading factor. Our findings can provide policymakers and managers with RB design criteria to maximize P retention.
Liver Transplantation in Acute-on-Chronic Liver Failure: Excellent Outcome and Difficult Posttransplant Course
Authors: Chen Guang-Hou , Wu Ruo-Lin , Huang Fan , Wang Guo-Bin , Zheng Mei-Juan , Yu Xiao-Jun , Wang Wei , Hou Liu-Jin , Ye Zheng-Hui , Zhang Xing-Hua , Zhao Hong-Chuan
Published: July 2022

Background

Acute-on-chronic liver failure (ACLF) patients have high mortality in a short period of time. This study aimed to compare the prognosis of transplanted ACLF patients to that of nontransplanted ACLF patients and decompensated cirrhosis recipients.

Methods

Clinical data of 29 transplanted ACLF patients, 312 nontransplanted ACLF patients, and 60 transplanted decompensated cirrhosis patients were retrospectively collected. Propensity score matching (PSM) analysis was used to match patients between different groups.

Results

After PSM, the 90-day and 1-year survival of transplanted ACLF patients was significantly longer than that of nontransplant controls. Although the 90-day survival and 1-year survival of ACLF recipients was similar to that of decompensated cirrhosis controls, ACLF recipients were found to have longer mechanical ventilation, longer intensive care unit (ICU) stay, longer hospital stay, higher incidence of tracheotomy, higher expense, and higher morbidity of complication than matched decompensated cirrhosis controls. The 90-day and 1-year survival of transplanted ACLF grade 2–3 patients was also significantly longer than that of nontransplanted controls.

Conclusions

Liver transplantation can strongly improve the prognosis of ACLF patients. Despite having more burdens (including longer mechanical ventilation, longer ICU stay, higher incidence of tracheotomy, longer hospital stay, higher hospitalization expense, and higher complication morbidity), ACLF recipients can obtain similar short-term and long-term survival to decompensated cirrhosis recipients. For severe ACLF patients, liver transplantation can also significantly improve their short-term and long-term survival.
Effects of Zinc Methionine Hydroxy Analog Chelate on Laying Performance, Serum Hormone Levels, and Expression of Reproductive Axis Related Genes in Aged Broiler Breeders
Authors: Yang Bowen , Gong Jiangang , Jing Jialin , Hao Yanshuang , Li Shupeng , Liu Guanzhong , Feng Zhihua , Zhao Guoxian
Published: July 2022

Inorganic zinc (Zn) supplements are commonly used in poultry feeds, but their low utilization results in the increase of Zn excretion. Thus, to provide a new perspective for the substitution of inorganic Zn, a novel Zn methionine hydroxy analog chelate (Zn-MHA) was studied in the present study to evaluate its effects on laying performance, serum hormone indexes and reproductive axis-related genes in broilers breeders. A total of 480 Hubbard breeders (56-week-old) were fed a basal diet (containing 27.81 mg Zn/kg) without Zn addition for 2 weeks, and then allocated to 4 groups with 6 replicates (each replicate consisting of 10 cages and 2 breeders per cage) for 10 weeks. Four treatment diets given to broiler breeders included the basal diet added with 25, 50, and 75 mg/kg of Zn-MHA and 100 mg/kg of Zn sulfate (ZnSO4). The laying rate, egg weight and feed conversation ratio increased in the 75 mg/kg Zn-MHA group compared to the ZnSO4 group. The eggshell thickness was not decreased with the addition of 50 mg/kg and 75 mg/kg Zn-MHA in the diet compared to the 100 mg/kg ZnSO4 group. There was a significant improvement in the reproductive performance of breeders in the 75 mg/kg Zn-MHA group, including the fertility and 1-day-old offspring weight. Besides, serum sex hormone levels including FSH and P4 increased significantly in 75 mg/kg Zn-MHA group. No significant effect on the ovarian weight or the number of follicles in broiler breeders was observed by supplementing Zn-MHA. Compared to the 100 mg/kg ZnSO4 group, dietary supplementation with 75 mg/kg of Zn-MHA showed an up-regulation of the FSHR mRNA in the granular layer of follicles. However, dietary supplementation of Zn-MHA had no effects on mRNA expressions of the ovarian LHR and PRLR genes. These findings reinforce the suggestion that Zn-MHA (75 mg/kg) could replace ZnSO4 (100 mg/kg) as a Zn supplement in diet of broiler breeders, which resulted in better laying and reproduction performances by regulating the expression levels of reproductive axis related genes and serum hormone levels.
Development of an Automatic Air-Driven 3D-Printed Spinal Posture Corrector
Authors: Asadullah G. M. , Ali Md. Hazrat , Hashikura Kotaro , Kamal Md Abdus Samad , Yamada Kou
Published: July 2022

Billions of people are using smartphones and computers with poor posture. A careless attitude towards spinal posture could be dangerous for long-term spinal health, leading eventually to curvature of the spine. Ignoring this fact and its treatment at the early stage will significantly deteriorate spinal health and force surgical intervention. Instead of developing an automated posture-correcting system, the existing research mostly focused on a posture-monitoring system to inform the users via a human interface, e.g., Bluetooth-based devices. Therefore, this paper proposes a novel posture-correction method to automatically prevent spinal disease by facilitating proper posture habits. Specifically, we develop a fluid-driven wearable posture corrector, whose skeleton can be fabricated simply using a 3D printer, to estimate angular posture deviation using sensors and provide appropriate assistance to correct the posture habit of the user. Mounted sensors provide the degree of postural bending, and a controller regulates the appropriate signals to provide a friendly pulling force as a reminder to the user through a fluid-driven actuator. The skeleton with a fluid-driven tool is designed to mimic the motion of the spinal posture by activating the actuator, which injects (or releases) the fluid into (or from) the skeleton frame and regulates forces to reduce the angular deviation of the skeleton. The 3D-printed skeleton with a flexible rubber tube has been experimentally evaluated to ensure proper actuating mechanism through the adjustment of air pressure. It is found that, by applying air pressure in the range of 0 to 101.4 kPa, the skeleton is pulled back approximately 1 N to 7 N forces, minimizing the angle up to 12.44∘ with respect to the initial steady stage, which leads to a maximum posture correction of 32.55% angle (θ) of poor posture. From the above experiments, we ensure the functionality of the proposed posture corrector in producing backward forces to correct the posture automatically.