bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTASI PERATURAN DAERAH KABUPATEN PONOROGO NOMOR 1 TAHUN 2012 TENTANG RENCANA TATA RUANG WILAYAH (RTRW) DALAM PEMANFAATAN RUANG TERBUKA HIJAU (RTH)
Authors: Putra Gilang Gunawan
Published: June 2023

Gilang Gunawan Putra. NPM 20421018. IMPLEMENTATION OF REGIONAL REGULATIONS OF PONOROGO REGENCY NUMBER 1 YEAR 2012 CONCERNING REGIONAL SPATIAL PLAN (RTRW) IN THE UTILIZATION OF GREEN OPEN SPACE (RTH). Public Administration, SlametRiyadi University Surakarta. Theses.Unpublished.

 

This study aims to describe the implementation of regional spatial planning policies in the use of green open spaces in Ponorogo Regency, and describe what factors influence the implementation of regional spatial planning policies in the use of green open spaces in Ponorogo Regency.

 

The type and analysis of data used a descriptive qualitative approach. Sources of data consist of primary data in the form of direct interviews and secondary data is data collected from observations and institutional literature related to research. Data collection techniques using interviews, observation and documentation.Data analysis techniques with data reduction, data presentation and drawing conclusions. Test the validity of the data using data source triangulation techniques and member check.

 

This study uses the Edward III Implementation theory, the results of the study show that the implementation of Spatial Planning Policy in the utilization of Green Open Space in Ponorogo Regency is generally carried out well, things that have been implemented are realization, socialization, and reports from SKPD related to the implementation of the Ponorogo Regency Regional Regulation Number 1 of 2012 concerning Regional Spatial Planning in Utilization of Green Open Space. Implementation of the Spatial Planning Policy in the use of Green Open Space in Ponorogo Regency from the communication aspect, in principle the Regency Government has socialized the city's spatial plan. Aspects of resources are sufficient, but still lacking in quantity and quality. Aspect of disposition, policy implementers have quite good characteristics.

 

Keywords: Implementation, Regulations, Green Open Space
ANALISIS PELAYANAN ONE DAY SERVICE DI DINAS PENDIDIKAN DAN KEBUDAYAAN KABUPATEN SRAGEN
Authors: Purnomo Edy , Winarti Winarti , Pramono Joko
Published: June 2023

Penelitian ini bertujuan untuk menganalisis Pelayanan One Day Service di Dinas Pendidikan dan Kebudayaan Kabupaten Sragen. Metode penelitian yang digunakan adalah pendekatan deskriptif kualitatif dengan wawancara, observasi, dan dokumentasi. Informan sebagai sumber data dalam penelitian ini merupakan informan internal (penyelenggara pelayanan) dan informan eksternal (pengguna layanan), yaitu pengambilan sampel dengan maksud dan tujuan tertentu. Metode yang digunakan dalam menentukan sumber data adalah metode purposive sampling. Hasil penelitian ini menunjukkan bahwa berdasarkan unsur-unsur pelayanan publik dari Purwanto, Tyastianti, Taufiq, Novianto (2017), terbukti Pelayanan One Day Service di Dinas Pendidikan dan Kebudayaan Kabupaten Sragen dapat menjadi solusi untuk meningkatkan kualitas pelayanan publik, namun perlu dilakukan upaya untuk meningkatkan kualitas sumber daya manusia dan sarana prasarana yang memadai agar Pelayanan One Day Service dapat berjalan dengan optimal terutama peningkatkan kualitas sumber daya manusia dan sarana prasarana yang memadai dalam pelaksanaan Pelayanan One Day Service di Dinas Pendidikan dan Kebudayaan Kabupaten Sragen.
 
Kata Kunci: Pelayanan, Publik, One Day Service.
STRATEGI MEMBANGUN ZONA INTEGRITAS ANTI KORUPSI DI POLRES KOTA BANDARA SUKARNO HATTA
Authors: Pujianto Agung
Published: June 2023

This study aims to describe the strategy of building an anti-corruption integrity zone at the Soekarno Hatta Airport City Police to make services better.
 
This type of research is development research through qualitative descriptive. The subjects of this study were employees at Soekarno Hatta Airport who were the main informants. Sources of data from this study are informants, documents and events. The data obtained by using purposive sampling. The data analysis method in this qualitative research is an interactive data analysis method.
 
The results determined that the SWOT matrix analysis produced 6 alternative strategies, namely increasing the professionalism, fulfilling the infrastructure, having a budget, increasing human resources, giving regulations to prevent corruption and giving strict sanctions. This research finds the twists and turns of the Polres' efforts in implementing strategy, innovation, empowering employees as human capital and the results of building integrity and anti-corruption zones. The conclusion is that the strategy to build an anti-corruption integrity zone at the Soekarno Hatta Airport City Police has not run optimally, because there are still several members' rights that have not been fulfilled. Suggestion for the chief of the police resort (Kapolres) is that he can fulfill the rights of members of the Soekarno Hatta Airport Police.
 
Keywords: Strategy, integrity, anti-corruption
EFEKTIVITAS PELAKSANAAN PROGRAM KOTA TANPA KUMUH (KOTAKU) TAHUN 2021 DI DESA KLITIK KECAMATAN WONOASRI KABUPATEN MADIUN
Authors: Triastuti Nining , Pramono Joko , Haryanto Aris Tri
Published: June 2023

Penelitian ini bertujuan untuk menentukan efektivitas pelaksanaan program Kotaku dalam mengatasi kawasan kumuh di Desa Klitik. Obyek penelitian meliputi aspek-aspek pengukuran standar efektivitas Program Kotaku, yang mencakup pencapaian tujuan, integrasi, dan adaptasi. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan dalam penelitian ini meliputi wawancara, observasi, dan dokumentasi. Analisis data dilakukan dengan menggunakan model analisis data kualitatif interaktif oleh Miles, Huberman, dan Saldana (2014). Hasil penelitian menunjukkan bahwa pelaksanaan Program Kotaku di Desa Klitik cukup efektif dan berhasil mencapai tujuannya. Infrastruktur di desa telah membaik dengan pelaksanaan program ini. Namun, terdapat beberapa kendala dalam pelaksanaan Program Kotaku di Desa Klitik, seperti kurangnya dana operasional untuk program dan keterbatasan sumber daya manusia dan aspek teknis.
 
Keywords : Efektivitas, Sosialisasi, Integrasi, Adaptasi
IMPLEMENTASI PERATURAN KEPALA DAERAH NO 56 TAHUN 2021 TENTANG RENCANA DETAIL TATA RUANG (RDTR) DALAM PEMANFAATAN RUANG TERBUKA HIJAU (RTH) DI WILAYAH PERKOTAAN KECAMATAN PILANGKENCENG KABUPATEN MADIUN
Authors: Dwiantoro Aang Rudi , Winarti Winarti , Pramono Joko
Published: June 2023

Peraturan kepala daerah no 56 tahun 2021 tentang rencana detail tata ruang (rdtr) dalam pemanfaatan ruang terbuka hijau (rth) di wilayah perkotaan kecamatan pilangkenceng kabupaten Madiun merupakan langkah Pemerintah Kabupaten Madiun untuk menyikapi masalah tata ruang.
 
Tujuan dari permasalahan tersebut adalah menemukan implementasi peraturan kepala daerah no 56 tahun 2021 tentang rencana detail tata ruang (rdtr) dalam pemanfaatan ruang terbuka hijau (rth) di wilayah perkotaan kecamatan pilangkenceng dengan menggunakan Teori Edward III, 1908:10) yaitu (1) komunikasi, (2) sumberdaya, (3)disposisi (4) struktur birokrasi.
 
Hasil penelitian menunjukkan bahwa imlementasi peraturan dari Pemerintah Kabupatn Madiun hingga kemasyarakat berjalan cukup baik. Diharapkan komunikasi antar organisasi perangkat daerah untuk menjalaskan sebuah reaturan tidaklah terputus, agar tujuan penyampaian sebuah kebijakan tepat sasaran.
 
Keyword: Implementasi, ruang terbuka hijau, tata ruang
AKUNTABILITAS PENGELOLAAN DANA DESA TAHUN 2022 DI DESA JURUG KECAMATAN SOOKO KABUPATEN PONOROGO PROVINSI JAWA TIMUR INDONESIA
Authors: Prasetyo Yudi , Suwardi Suwardi , Sardjono Herning Suryo
Published: June 2023

Penelitian ini bertujuan menganalisa akuntabilitas pelaksaan Dana Desa Tahun 2022 di Desa Jurug Kabupaten Ponorogo. Hal ini dilatarbelakangi adanya permasalahan terkait dengan pengelolaan Dana Desa di Desa Jurug yang seharusnya tingkat penyerapan anggaran serta pelaksanaannya terus mengalami peningkatan positif dari tahun ke tahun, akan tetapi ditinjau dari laporan pertanggungjawaban belum dilaksanakan dengan baik. Sumber Data dalam penelitian ini adalah informan yang terkait langsung dengan pengelolaan Dana Desa di Desa Jurug baik informan internal (Pemerintah Desa Jurug) dan informan eksternal (tokoh masyarakat dan pendamping desa). Teori akuntabilitas dalam penelitian ini menggunakan Ellwood dalam Mardiasmo (2009: 21), pengelolaan dana desa harus didasari atas akuntabilitas proses, akuntabilitas kejujuran dan hukum, akuntabilitas kebijakan dan akuntabilitas program.
 
Keywords : Akuntabilitas Proses, Akuntabilitas Kejujuran dan Hukum,
 
Akuntabilitas Kebijakan, Akuntabilitas Program.
The Song of the Kedidi: The Embodiment of a Hero in a Malay Folktale as an Intangible Cultural Heritage
Authors: Harun Harryizman , Abdullah Noor Aziah
Published: June 2023

The present study is part of a movement to safeguard Malay folktales as an unsung intangible cultural heritage (ICH). A folktale is a representation of oral traditions and expressions. This study converges on literary folktales as a revitalised form of oral folktales. As urged by UNESCO, the viability of the ICH is achievable via scientific research, among other things. Therefore, considering the small amount of study on Malay folktales at the moment, the current study endeavours to examine the folktale The Song of the Kedidi (TSoK) of its hero embodiment as one of the dramatis personae. The framework of Propp’s dramatis personae, which is based on Russian folktales, grounds the examination. This study examines whether the heroes from the Russian folktales embody TSoK. The thematic qualitative text analysis (TQTA) was employed to examine TSoK. It was conducted in Atlas.ti environment to assure rigour and trustworthiness. The study’s findings suggest that TSoK embodies heroes from Russian folktales. However, a conundrum exists in the embodiment of the hero. There is a conflict between the dramatis personae’s role, and such an enigma calls for the involvement of other dramatis personae, which is reserved for future works. As a crusade to safeguard the Malay folktales as the unsung ICH, the findings create a platform for scholars of similar interests to pursue the examination of heroes in other Malay folktales. Most importantly, the findings are necessary for endless recreation and transmission of knowledge to safeguard the Malay folktale as a living heritage. This act echoes one of UNESCO’s formal education measures to foster society’s respect, recognition, and awareness of the ICH.
A Study on EFL Teacher Strategies in Utilizing ICT for Regional Public Highschool of Indonesia
Authors: Kibar Andi Halima , Ampa Andi Tenri , Nappu Syamsiarna
Published: June 2023

This mixed-methods study investigates the strategies employed by EFL teachers in integrating Information and Communication Technology (ICT) into their teaching practices within a regional public high school in Indonesia. By employing a combination of qualitative and quantitative data collection methods, the study draws upon a sample of teachers' perspectives via structured interviews and questionnaire responses. The English teachers of SMA Negeri 1 Maros were involved as the subject of the Research. The findings reveal that teachers utilize a range of ICT tools, such as LCD/LED projectors, PowerPoint presentations, audio-visual technologies, and radio broadcasts, with the primary aim of enhancing teaching efficacy and student engagement. The data suggests that the use of ICT significantly influences student comprehension and learning outcomes, with pupils demonstrating an accelerated understanding of material when taught via ICT-based methodologies. Therefore, the study provides valuable insights into the role of ICT in English language teaching in Indonesia, particularly shedding light on teachers' ICT utilization strategies and the impacts on student learning outcomes. These findings may inform future policy and practice in education, potentially guiding initiatives for ICT integration in the wider context of language education.
Quizizz Based Application in Teaching Reading in an Indonesian EFL Junior High School Context
Authors: Nurhaya Nurhaya , Abduh Amirullah
Published: June 2023

This study employs a case study design with a qualitative descriptive approach that aimed to shed light on; (1) the teachers’ perception on Quizizz in teaching reading, (2) the implementation of Quizizz in teaching reading and, (3) the impacts of Quizizz on students’ reading comprehension.  The participants of this research were three teachers selected through purposive sampling. The instruments used were observation, interview and teachers’ documents. The findings of this research revealed that; (1) stemming on teachers’ interview, teachers’ perception on Quizizz in teaching reading was classified into two categories namely highly and moderately perceived on Quizizz in teaching reading. Furthermore, (2) the implementation of Quizizz in teaching reading was classified into two categories namely moderately implemented and lowly implemented in utilizing Quizizz in teaching reading. Finally, (3) the findings had shown that Quizizz had positive impacts on students’ reading comprehension in literal level, inferential level, critical level and creative level. The findings of this study underline the potential of digital applications like Quizizz in revolutionizing the pedagogical approach in Indonesian EFL classrooms, particularly in the teaching of reading skills.
The Use of Short Story as A Teaching Vocabulary Resource to The Second Grade of Babul Khaer Islamic Boarding School Bulukumba
Authors: Nasyirah Ummul , Rahman Asfah , Wello Muhammad Basri
Published: June 2023

The purpose of this study was to investigate the effectiveness of using short stories as a teaching vocabulary resource for second grade students at Babul Khaer Islamic Boarding School Bulukumba. The study employed a quasi-experimental design with a pretest-posttest control group to evaluate the impact of short stories on students' vocabulary acquisition. The participants in this research were 16-member classes of second-grade students (XI. Exact-2 as the experimental class and XI. Social Science-2 as the control class). The study instrument consisted of a test and a questionnaire. This data showed that the pre-test mean score for the experimental class was 47.31 and that it increased to 56.75 on the post-test. The findings revealed that students in the experimental group, who were exposed to short stories, significantly improved their vocabulary compared to the control group. The results suggest that short stories can be a valuable resource for vocabulary instruction in second grade students. Furthermore, the study highlights the potential implications of integrating short stories into the curriculum, including enhanced student engagement, improved critical thinking skills, and enriched cultural understanding. Additional research is needed to further explore the long-term effects of using short stories for vocabulary instruction and its impact on students' overall language development.
Концептуальні засади формування перспективної системи дисциплінарної відповідальності військовослужбовців Збройних Сил України в контексті євроатлантичної інтеграції
Authors: Залужний В. Ф. , Шаптала С. О. , Кримець Л. В. , Пашинський В. Й.
Published: June 2023

Дисциплінарна відповідальність військовослужбовців Збройних Сил України розглядається як вид спеціальної юридичної відповідальності, спрямований на забезпечення правомірної поведінки військовослужбовців під час виконання ними обов’язків військової служби, яка реалізується у випадку порушення визначеною категорією суб’єктів військової дисципліни з метою відновлення порядку та запобігання подальшим дисциплінарним правопорушенням. Визначено принципи дисциплінарної відповідальності військовослужбовців, що зумовлюють зміст, напрями та процедури здійснення, відповідають фундаментальним національним та європейським цінностям, а також етичним принципам Північноатлантичного альянсу.

Розглянуто перспективну систему дисциплінарної відповідальності військовослужбовців, яка охоплює: а) суб'єкта дисциплінарного проступку; б) суб'єкта дисциплінарної влади, уповноваженого діяти у встановленому законом порядку; в) підставу (дисциплінарний проступок); в) санкції або інші методи впливу на поведінку військовослужбовця. Зазначена система спрямована на досягнення мети дисциплінарної відповідальності, якою є забезпечення військової дисципліни та запобігання дисциплінарним проступкам, а також на реалізацію її функцій: регулятивної, превентивної, виховної, стимуляційної.
Fotobiomodulação no tratamento da radiodermite: um estudo de caso
Authors: Oliveira Daiane Flores de , Paines Gabrielle Peres , Berni Eduarda Brollo , Ferreira Fabiana dos Santos , Pivetta Hedioneia Maria Folleto
Published: June 2023

Introdução: A radiodermite é uma complicação comum observada em pacientes submetidos a radioterapia para o tratamento do câncer. O objetivo deste relato de caso é verificar os efeitos da terapia por Fotobiomodulação (FBM) no tratamento da radiodermatite em paciente com diagnóstico de câncer de mama. Método: Estudo de caso único com paciente do sexo feminino, 38 anos, diagnóstico de câncer de mama Grau II de Notinghan; realizou quimioterapia neoadjuvante a retirada do tumor através de setorectomia. Recebeu tratamento por radioterapia em que desenvolveu radiodermatite grau I e II, de acordo com Radiation Therapy Oncology Group (RTGO) A terapia por fotobiomodulação utilizada foi LED vermelho (658 nm) a 4 J/cm², emissão de feixe contínuo, com 48h de intervalo entre as aplicações. No total, 04 sessões durante um período de 02 semanas foram administradas para tratamento da radiodermatite. A evolução do quadro foi registrada mediante registro fotográfico pré e pós-intervenção. Resultados: Observou-se melhora clínica e resolução do quadro de radiodermatite após a quarta sessão por LED vermelho. As alterações pigmentares causadas pela radiodermite reduziram, tanto a hiperpigmentação quanto a hiperemia desapareceram, recuperando o aspecto hígido da pele. Também foi observado diminuição na temperatura da mama ao final do tratamento. Conclusão: Este relato de caso demonstra potencial efeito bioestimulante e reparador da fotobiomodulação por LED vermelho na resolução da radiodermite nos graus I e II.
Efeitos do cicloergômetro no pós-operatório sobre a capacidade funcional e o tempo de hospitalização em adultos submetidos a cirurgia cardíaca: protocolo de revisão sistemática
Authors: Pacheco João Paulo Rodrigues , Leão Eduardo Pinheiro , Pinto Ana Carolina Pereira Nunes , Mendes Adilson , Matias Larissa de Magalhães Doebeli , Boca Ioan Cosmin , Macedo Juliana Ribeiro Fonseca Franco de , Lunardi Adriana Claudia , Santos Elinaldo da Conceição dos
Published: June 2023

Introduction: Among patients undergoing cardiac surgery, some pulmonary and cardiac complications can be observed, which can increase the length of hospital stay. The cycle ergometer is used to try to improve this clinical scenario. However, some inconsistencies can be observed in the literature. Objective: To synthesize evidence on the effects of cycle ergometer use in the in-hospital postoperative period in relation to control therapy without cycle ergometer use on functional capacity and length of hospital stay in adults undergoing cardiac surgery. Methods: Systematic review of randomized clinical trials with patients undergoing cardiac surgery, to evaluate the effects of cycle ergometer use compared to control without cycle ergometer use. Primary outcomes: functional capacity and length of hospital stay. Searches: Medline, EMBASE, PEDro, Pubmed, Allied and AMED, Cinahl, Lilacs, Scielo, Scopus and Cochrane Central, ClinicalTrials.gov, ReBEC, and the references of included studies. Study selection will be conducted by three authors. The risk of bias will be assessed by two independent authors using the Cochrane Risk of Bias 2 (RoB 2) tool and conflicts will be resolved through consensus (in the absence of consensus, a third author will make the decision). The inverse variance method and random effects model will be considered in the meta-analysis. Continuous variables will be analyzed by weighted mean difference and dichotomous variables by relative risk (RR). We will use I2 statistics to estimate the amount of heterogeneity between studies. Discussion: Different cardiac surgeries are performed all over the world, and have been widely investigated. However, some gaps and controversies can be observed. Therefore, a systematic review is essential to clarify existing gaps.
Formación docente para la atención de personas con discapacidad como elemento necesario dentro de la educación en derechos humanos
Authors: Prince Torres Ángel Carmelo
Published: June 2023

Este artículo tuvo como propósito general comprender la importancia de la formación docente para la atención de personas con discapacidad como elemento esencial dentro de la educación en derechos fundamentales. Con esta intención, se configuró un trabajo documental cualitativo utilizando textos teóricos y jurídicos para el logro de los objetivos específicos. Se concluyó que la educación sobre derechos humanos parte de la inclusión, por lo que es crucial insertar en la capacitación docente con esta perspectiva, a la preparación sobre el abordaje de personas discapacitadas en los contextos educaciones y se destacó el papel de los Estados y sus gobiernos como determinantes en la formación de políticas públicas que permitan el entrenamiento de profesores y profesoras como difusores y defensores de los derechos naturales.
“YÜZYILA DAMGASINI VURAN ÖNDER:ATATÜRK” KİTABINDA DÜNYA LİDERİNİ ANLAMAK, ANLAYABİLMEK
Authors: BATIR Betül
Published: June 2023

Tural, Sadık K. (2022), Yüzyıla Damgasını Vuran Önder: Atatürk, Gözden geçirilmiş ve eklerle 3. Baskı, Ankara: Eğitim Dostları Vakfı Yayını künyeli kitabın incelemesi yapılmıştır.

Türk Dili ve Edebiyatı alanında bilim insanı olan Prof. Dr. Sadık K. Tural tarafından kaleme alınan Yüzyıla Damgasını Vuran Önder: Atatürk isimli eser kronolojik tarih metoduyla yazılmış bir eser olmayıp tarihçiler tarafından yazılan eserlerden bu anlamda farklılık göstermektedir. Türk diline hakim bir bilgin olan Sadık K. Tural, kavramlarla durum tespiti yaparak Mustafa Kemal Atatürk’ü anlamayı ve anlatmayı mahirane sözcük ve derin cümlelerle ifade etmiştir. Kitabın ilk baskısı Nisan 2015 yılında (2.500 adet) ve ikinci baskısı Ocak 2018 yılında (1.500 adet) yayınlanmıştır. Editörlüğünü Prof. Dr. Serap Taşdemir’in yaptığı üçüncü baskı ise Eylül 2022 tarihinde (2.000 adet) Eğitim Dostları Vakfı’nın yayını olarak gözden geçirilerek ve eklemeler yapılarak gerçekleşmiştir. Kapakta yer alan Mustafa Kemal Atatürk’ün nadir fotoğraflarından biri Hanri Benazus’un arşivinden, Serpil Sümer ve Fuat Sümer tarafından seçilmiştir.
PENYULUHAN MENGENAI KESEHATAN REPRODUKSI REMAJA KEPADA SANTRI PUTRA DAN PUTRI DARUL ARQAM MUHAMMADIYAH GARUT
Authors: Esa Esa Risi Suazini , Lina Lina Humaeroh , Fitri Fitri Hanriyani , Rosita Rosita Alvia
Published: June 2023

World Health Organization (WHO) 2014, informed that the proportion of adolescents is around 18%, or around 1.2 billion. (WHO, 2014) The results of the 2010 population census in Indonesia were 43.5 million, this number if proportioned the same, around 18%. Of this 43.5 million, only 20% of adolescents are not dating. They dated from <11 years of age. Teenagers mostly started dating aged 15-17 years, which is almost 50%. Pre-marital sex behavior occurs mostly at the age of 20-24 years, this behavior is more than 3 times that of young men. (Ministry of Health, Republic of Indonesia, 2017). Premarital sex has risks and bad effects, the risks that have to be faced with unwanted pregnancy (KtD), early pregnancy, abortion and transmission of sexually transmitted infections (STIs). an average of 25%. Very ironic, from 25% the highestknowledge is 60.8%, namely knowing that HIV-AIDS transmission can be reduced by using condoms. (Ministry of Health of the Republic of Indonesia, 2017). Health care for adolescents in Garut has not been running optimally. (Esa Risi Suazini, 2020). This condition shows that teenagers' exposure to health information is still low and has an impact on adolescent health knowledge which is also low. Based on the explanation above, it is very necessary to make efforts to increase adolescent knowledge about their reproductive health. The purpose of this community service is to disseminate adolescent reproductive information, increase adolescent knowledge about the correct adolescent reproductive health and shape healthy reproductive attitudes and behaviors in adolescents. The conclusion regarding the results of the dissemination of reproductive health information to adolescents, namely adolescents really need correct information about reproductive health. and adolescents have a positive attitude to always take care of their reproductive organs. After knowing the bad effects of sexual deviance, adolescents have a negative attitude towards sexual deviance. Our hope is that teenagers will survive to always avoid sexual deviant acts
Experiences of Thai-Muslim patients regarding inconsistent antiretroviral therapy adherence: An exploratory descriptive qualitative study
Authors: Perngmark Pajongsil , Sahawiriyasin Oatcharaphon , Holroyd Eleanor
Published: June 2023

Background: Antiretroviral therapy (ART) has played a crucial role in saving countless lives of patients with HIV/AIDS across the world. However, despite its effectiveness, ART adherence still falls short globally, and non-adherence remains the primary cause of treatment failure. In the rural areas of southern Thailand, where the population is predominantly conservative Muslims, there has been an observed increase in ART non-adherence.
Objective: This study aimed to explore experiences of inconsistent ART adherence among Thai-Muslim patients with HIV/AIDS (PWHAs) in southern Thailand. In addition, the perspectives of healthcare providers were also sought.
Methods: Data were collected by conducting semi-structured in-depth interviews with ten Thai-Muslim PWHAs and five healthcare providers at a Voluntary Counseling-and-Testing Clinic. A content analysis approach was utilized to analyze the data.
Results: Inconsistent ART adherence was reported. Religion/spiritual imperatives, forgetfulness, inadequate knowledge (of drug side effects and drug regime), misunderstandings (about being symptom-free and feeling well), boredom from long-term drug-taking regimes, as well as poor transportation and lack of family support (arising from non-disclosure of one’s HIV-serostatus due to HIV stigma) were emergent themes derived from the interviews with Thai-Muslim PWHAs. The healthcare providers’ interview data revealed their need for the integration of Islamic beliefs to provide better care.
Conclusion: It is essential for healthcare teams to work collaboratively with patients’ religious beliefs to enhance ART adherence. Clinical nurses can contribute to the promotion of HIV-care services by integrating Islamic beliefs and Muslim culture into their practice, thus increasing patients' knowledge and motivation for ART adherence. This could entail utilizing Islamic prayer rituals as drug reminders, elaborating on Islamic moral beliefs concerning sickness and healing, and integrating the cultural imperatives of self-care in the Muslim community into ongoing care delivery. Cross-cultural nursing education and specialized training in HIV care should incorporate knowledge about Islamic and Muslim cultural beliefs.
Uncertainty of parents due to having children with cancer: A concept analysis
Authors: Nurhidayah Ikeu , Nurhaeni Nani , Allenidekania Allenidekania , Gayatri Dewi , Rustina Yeni
Published: June 2023

Background: Parents of newly diagnosed cancer children often experience significant concerns about the implications of the diagnosis. They find themselves in challenging decision-making situations, navigating through uncertain conditions following the disclosure. Uncertainty is a prevailing issue in healthcare, yet its interpretation and application within the context of health and nursing practice exhibit multiple meanings and variations.  
Objective: This study aimed to clarify the concept of parental uncertainty arising from having children with cancer.                                                             
Methods: The concept analysis followed the steps outlined by Walker and Avant. A thorough literature search was conducted using the Embase, CINAHL, and MEDLINE databases to identify articles published between 1980 and 2022.
Results: The literature search yielded 147 articles from various disciplines, including health, nursing, medicine, psycho-oncology, and management. After analysis, 20 articles were selected for inclusion. This study identified four key attributes of parental uncertainty associated with having a child with cancer: (1) emotional disturbance, (2) unpredictability, (3) insufficient information, and (4) problems with decision-making. The antecedents of parental uncertainty encompassed the complexity of the disease, the diagnostic and treatment processes, the hospital environment, communication, and support from credible authorities. The consequences of parental uncertainty included the pursuit of new information, parental adaptability to their role, and parental distress.
Conclusion: Understanding the four attributes of parental uncertainty, along with their antecedents and consequences, can facilitate the future development and operational translation of the concept of uncertainty in nursing practice. This concept is valuable in the evidence-based provision of nursing care to parents of children with cancer, enabling comprehensive recognition and assessment of parental uncertainty and the implementation of appropriate interventions that are sensitive to parental experiences. Ultimately, this approach promotes the adaptation of both the child and the parent.
Quality of life and its correlates in pretreatment patients with locally advanced head and neck cancer: A cross-sectional study in Thailand
Authors: Pimvichai Sirinya , Matchim Yaowarat , Sinthusake Tanadej , Wongkalasin Kiratiya
Published: June 2023

Background: Locally advanced head and neck cancer (LAHNC) can significantly impact the quality of life of patients in various ways. However, several factors can contribute to the decrease in quality of life. In Thailand, there is limited knowledge about the factors that affect the quality of life of patients with LAHNC before they receive treatment. Objective: This study aimed to examine the correlations between Palliative Performance Scale (PPS), family income, body mass index (BMI), age, comorbidity index, and the quality of life of patients with LAHNC before they undergo treatment. Methods: A correlational cross-sectional study was conducted, and data were collected from 94 pretreatment patients with LAHNC who were admitted to a cancer center in central Thailand using purposive sampling. The data collection instruments included a demographic data form, a medical record form, the Charlson Comorbidity Index (CCI), the Palliative Performance Scale (PPS), and the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) version 4. Descriptive statistics, Pearson’s correlation, and Spearman’s rank correlation were used to analyze the data. Results: All study participants completed the questionnaire. The results showed that the overall quality of life of the patients was moderate. PPS, family income, and body mass index were moderately positively correlated with quality of life (r = 0.494, p <0.01; r = 0.420, p <0.01; r = 0.339, p<0.01, respectively). Age had a moderate negative correlation with quality of life (r = -0.596, p <0.01), while comorbidity was not significantly associated with quality of life. Conclusion: The quality of life of patients with LAHNC before treatment was associated with various factors, including PPS, family income, body mass index, and age. These findings highlight the importance of nutritional support before treatment and the need for social support, especially for older adult patients, to improve their quality of life. The results of this study can be valuable for nurses in developing care programs that enhance the quality of life for patients with LAHNC during the pretreatment phase.
Factors related to preoperative uncertainty among patients with breast cancer in Wenzhou, China: A cross-sectional study
Authors: Shen Huaiyu , Masingboon Khemaradee , Samartkit Niphawan
Published: June 2023

Background: One of the most prevalent psychological signs of breast cancer is uncertainty, which is more prevalent in Chinese patients during the preoperative period. Despite the numerous factors contributing to preoperative uncertainty, there is limited relevant research conducted in China.
Objective: This study aimed to describe the current state of preoperative uncertainty and to investigate the relationship between anxiety, illness perception, social support, and preoperative uncertainty in patients with breast cancer in Wenzhou, China.
Methods: This cross-sectional research used a simple random sampling technique to select 122 participants from a university hospital in Wenzhou, China, from July 2022 to December 2022, employing validated instruments. Descriptive statistics and Pearson’s correlation coefficient were utilized to analyze the data.
Results: The average preoperative uncertainty scores of the patients fell within a moderate range (M = 61.92, SD = 7.51). Significant correlations were found between anxiety (r = 0.638, p <0.01), illness perception (r = 0.704, p <0.01), social support (r = -0.481, p <0.01), and preoperative uncertainty.
Conclusions: The results can assist healthcare professionals, especially nurses, in recognizing the factors contributing to uncertainty before surgery in patients with breast cancer. This knowledge enables them to promptly address and minimize this issue, leading to improved outcomes.
A Difference-in-Differences Approach for Estimating Survey Mode Effects
Authors: Ollerenshaw Trent
Published: June 2023

Two common designs for identifying survey mode effects are cross-sectional approaches and experiments. But cross-sectional designs risk a combination of omitted variable bias and post-treatment bias when conditioned on respondent characteristics that are themselves mode sensitive. In theory, experiments obviate these biases, but only if the experiment occurs in tightly-controlled settings that avoid differential uptake. Considering the costliness of such experiments, I propose a difference-in-differences approach for estimating mode effects. Leveraging mixed-mode panel surveys, mode effects can be identified by comparing changes in responses for panelists who switch modes across waves to those who remain in the same modes. Difference-in-differences offers a cost-free alternative to experiments and potentially large bias reduction gains vis-à-vis cross-sectional designs. I apply DD by estimating the effects of completing live interviews vs. web surveys on racial attitudes and political knowledge in the 2016-2020 ANES and cognitive functioning measures in the 1992-2020 Health and Retirement Study.
Riemann Hypothesis on Grönwall's Function
Authors: Vega Frank
Published: June 2023

Grönwall's function $G$ is defined for all natural numbers $n>1$ by $G(n)=\frac{\sigma(n)}{n \cdot \log \log n}$ where $\sigma(n)$ is the sum of the divisors of $n$ and $\log$ is the natural logarithm. We require the properties of extremely abundant numbers, that is to say left to right maxima of $n \mapsto G(n)$. We also use the colossally abundant and hyper abundant numbers. There are several statements equivalent to the famous Riemann hypothesis. We state that the Riemann hypothesis is true if and only if there exist infinitely many consecutive colossally abundant numbers $N< N'$ such that $G(N)< G(N')$. Using this new criterion, we prove that the Riemann hypothesis is true.
On sums involving divisor function, Euler's totient function, and floor function
Authors: Sebata Junya
Published: June 2023

Every positive integer $l \in \mathbb{N}$ can be formed $l = (m + n)d$, provided $gcd(m,n)=1$. From this point of view, the next formulas $n=\sum_{d|l} \varphi(d)$ and $\frac{n(n+1)}{2}=\sum_{k=1}^{n} \varphi(k)[\frac{n}{k}]$, and these equivalence had been proved. In this paper on an extension of these results, the next identity is proved: $\sum_{k=1}^{n} \sum_{\substack{(a+b)c=k \\ gcd(a,b)=1}} f(a,b)\cdot g(c) = \sum_{k=1}^{n} \sum_{\substack{a+b=k \\ gcd(a,b)=1}} f(a,b) \sum_{i\leq [\frac{n}{k}]} g(i) = \sum_{a+b \leq n} f(\frac{a}{gcd(a,b)},\frac{b}{gcd(a,b)})\cdot g(gcd(a,b))$. We also show the next formulas are corollaries of it: $\sum_{k=1}^{n} \tau(k)=\sum_{k=1}^{n} [\frac{n}{k}] = \sum_{a+b \leq n} \frac{1}{\varphi(\frac{a+b}{gcd(a,b)})}$, $\sum_{d|n} f(d)\cdot g(\frac{n}{d}) = \sum_{k = 1}^{n} f(gcd(k,n))\cdot\frac{g(\frac{n}{gcd(k,n)})}{\varphi(\frac{n}{gcd(k,n)})}$, $\tau(n)=\sum_{a+b = n} \frac{1}{\varphi(\frac{a+b}{gcd(a,b)})}$, $\sum_{\substack{a+b=n \\ gcd(a,b)=1}} gcd(a-1,b+1) = \sum_{a+b=n} \frac{\varphi(n)}{\varphi(\frac{n}{gcd(a,b)})}$, and so on. In addition to it, we evaluate a sequence $\sum_{k=1}^{n} \varphi(k)\tau(k)$.
The cause–effect relation of tuberculosis on incidence of diabetes mellitus
Authors: Bisht Manoj Kumar , Dahiya Priyanka , Ghosh Sudip , Mukhopadhyay Sangita
Published: June 2023

Tuberculosis (TB) is one of the oldest human diseases and is one of the major causes of mortality and morbidity across the Globe. Mycobacterium tuberculosis (Mtb), the causal agent of TB is one of the most successful pathogens known to mankind. Malnutrition, smoking, co-infection with other pathogens like human immunodeficiency virus (HIV), or conditions like diabetes further aggravate the tuberculosis pathogenesis. The association between type 2 diabetes mellitus (DM) and tuberculosis is well known and the immune-metabolic changes during diabetes are known to cause increased susceptibility to tuberculosis. Many epidemiological studies suggest the occurrence of hyperglycemia during active TB leading to impaired glucose tolerance and insulin resistance. However, the mechanisms underlying these effects is not well understood. In this review, we have described possible causal factors like inflammation, host metabolic changes triggered by tuberculosis that could contribute to the development of insulin resistance and type 2 diabetes. We have also discussed therapeutic management of type 2 diabetes during TB, which may help in designing future strategies to cope with TB-DM cases.
Prediction for the surface settlement of double-track subway tunnels for shallow buried loess based on peck formula
Authors: Wang Shuangyuan , Song Zhanping , Tian Xiaoxu , Sun Yinhao , Zhang Yuwei
Published: June 2023

In the process of constructing double-track subway tunnels in shallow buried loess areas, the interaction of double-track tunnels is significantly influenced by the net distance and the cross-section size, which is challenging to control the surface settlement. Therefore, the surface settlement prediction is essential while constructing double-track subway tunnels in shallow buried loess areas. The paper analyzed the surface settlement law of shallow buried double-track tunnels in loess areas through theoretical research and numerical simulation. The research results show that with the decrease of the net distance, the surface settlement superimposed curve was double V shape -W shape - single V shape. When the superimposed curve is double V shape and W shape, the Peck formula was used to calculate the surface settlement curve of the single-track tunnel, then superimposed to obtain the final surface settlement curve. When the superimposed surface settlement curve was V shape, based on the Peck formula, the formula for predicting the surface settlement suitable for symmetry and asymmetry was established. The net distance ratio and the area ratio were defined, and considering the tunnel’s interaction, the value and position of the maximum were corrected. Then numerical tests were carried out 16 times with different net distance ratios and area ratios, to determine the parameters of increments and position offsets of the maximum regarding the net distance ratio and the area ratio. Finally, two engineering were conducted for verifying the rationality and applicability exhibited by the prediction formula. The prediction formula served for predicting the surface settlement of double-track subway tunnels in shallow buried loess areas. Which can reduce construction risks and assure the safety of buildings above the ground.
Review article: new treatments for advanced differentiated thyroid cancers and potential mechanisms of drug resistance
Authors: Hamidi Sarah , Hofmann Marie-Claude , Iyer Priyanka C. , Cabanillas Maria E. , Hu Mimi I. , Busaidy Naifa L. , Dadu Ramona
Published: June 2023

The treatment of advanced, radioiodine refractory, differentiated thyroid cancers (RR-DTCs) has undergone major advancements in the last decade, causing a paradigm shift in the management and prognosis of these patients. Better understanding of the molecular drivers of tumorigenesis and access to next generation sequencing of tumors have led to the development and Food and Drug Administration (FDA)-approval of numerous targeted therapies for RR-DTCs, including antiangiogenic multikinase inhibitors, and more recently, fusion-specific kinase inhibitors such as RET inhibitors and NTRK inhibitors. BRAF + MEK inhibitors have also been approved for BRAF-mutated solid tumors and are routinely used in RR-DTCs in many centers. However, none of the currently available treatments are curative, and most patients will ultimately show progression. Current research efforts are therefore focused on identifying resistance mechanisms to tyrosine kinase inhibitors and ways to overcome them. Various novel treatment strategies are under investigation, including immunotherapy, redifferentiation therapy, and second-generation kinase inhibitors. In this review, we will discuss currently available drugs for advanced RR-DTCs, potential mechanisms of drug resistance and future therapeutic avenues.
Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish
Authors: Shaw Katherine , Therrien Mylène , Lu Chunyu , Liu Xiaochun , Trudeau Vance L.
Published: June 2023

Aromatase (Cyp19a1) is the steroidogenic enzyme that converts androgens into bioactive estrogens, and hence is in a pivotal position to mediate reproduction and sexual behavior. In teleosts, there are two aromatase paralogs: cyp19a1a that is highly expressed in granulosa and Leydig cells in the gonads with critical function in sexual differentiation of the ovary, and cyp19a1b that is highly expressed in radial glial cells in the brain with unknown roles in reproduction. Cyp19a1-/- mutant zebrafish lines were used to investigate the importance of the cyp19a1 paralogs for spawning behavior and offspring survival and early development. Mutation of cyp19a1b was found to increase the latency to the first oviposition in females. Mutation of cyp19a1b in females also increased the number of eggs spawned; however, significantly more progeny died during early development resulting in no net increase in female fecundity. This finding suggests a higher metabolic cost of reproduction in cyp19a1b-/- mutant females. In males, the combined mutation of both cyp19a1 paralogs resulted in significantly lower progeny survival rates, indicating a critical function of cyp19a1 during early larval development. These data establish the specific importance of cyp19a1b for female spawning behavior and the importance of the cyp19a1 paralogs for early larval survival.
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β
Authors: Park Jin-Hee , Hwang Jeong-Woo , Lee Hyun-ju , Jang Geum Mi , Jeong Yoo Joo , Cho Joonho , Seo Jinsoo , Hoe Hyang-Sook
Published: June 2023

Introduction

Lomerizine is a calcium channel blocker that crosses the blood–brain barrier and is used clinically in the treatment of migraines. However, whether lomerizine is beneficial in modulating neuroinflammatory responses has not been tested yet.

Methods

To assess the potential of lomerizine for repurposing as a treatment for neuroinflammation, we investigated the effects of lomerizine on LPS-induced proinflammatory responses in BV2 microglial cells, Alzheimer’s disease (AD) excitatory neurons differentiated from induced pluripotent stem cells (iPSCs), and in LPS-treated wild type mice.

Results

In BV2 microglial cells, lomerizine pretreatment significantly reduced LPS-evoked proinflammatory cytokine and NLRP3 mRNA levels. Similarly, lomerizine pretreatment significantly suppressed the increases in Iba-1, GFAP, proinflammatory cytokine and NLRP3 expression induced by LPS in wild-type mice. In addition, lomerizine posttreatment significantly decreased LPS-stimulated proinflammatory cytokine and SOD2 mRNA levels in BV2 microglial cells and/or wild-type mice. In LPS-treated wild-type mice and AD excitatory neurons differentiated from iPSCs, lomerizine pretreatment ameliorated tau hyperphosphorylation. Finally, lomerizine abolished the LPS-mediated activation of GSK3α/β and upregulation of DYRK1A, which is responsible for tau hyperphosphorylation, in wild-type mice.

Discussion

These data suggest that lomerizine attenuates LPS-mediated neuroinflammatory responses and tau hyperphosphorylation and is a potential drug for neuroinflammation- or tauopathy-associated diseases.
Accumulation of plasmacytoid dendritic cell is associated with a treatment response to DNA-damaging treatment and favorable prognosis in lung adenocarcinoma
Authors: Cha Yoon Jin , Kim Eun Young , Choi Yong Jun , Kim Chi Young , Park Min Kyung , Chang Yoon Soo
Published: June 2023

Introduction

Favorable responses to the treatment including immune checkpoint inhibitors (ICIs) have been consistently reported in lung cancer with smoking history. As the tumor microenvironment (TME) may be involved in the treatment response to ICIs, we aimed to investigate the TME of lung cancer with different smoking status.

Methods

Lung adenocarcinoma (LUAD) tissue (Tu) and adjacent normal-appearing lung tissue (NL) from current and never smokers were investigated by single-cell RNA sequencing and immunofluorescence and immunohistochemical staining. The clinical implications of identified biomarkers were validated using open-source datasets.

Results

The lungs of smokers had an increased proportion of innate immune cells in NL tissues, whereas Tu tissues had a lower proportion of these cells than those of non-smokers. Monocyte-derived macrophages (mono-Mc), CD163-LGMN macrophages, monocyte-derived dendritic cells (DCs), and plasmacytoid DCs (pDCs) were significantly enriched in smokers’ Tu. Among these clusters, pDCs, specifically enriched in the Tu of smokers. The expression of representative pDC markers, leukocyte immunoglobulin-like receptor A4 (LILRA4) and Toll-like receptor 9 (TLR9), was increased in the stromal cells of LUAD in patients with a smoking history. In an animal model of lung cancer, ionizing radiation induced robust TLR9 expressing immune cells in peritumoral area. Survival analysis using a TCGA-LUAD dataset indicated that patients overexpressing pDC markers exhibited superior clinical outcomes to age-, sex-, and smoking-matched control groups. Top 25% patients with high TLR9 expression exhibited significantly higher tumor mutational burden than that of low TLR9 expression group (bottom 25% patients) (5.81 mutations/Mb vs 4.36 mutations/Mb; P = 0.0059, Welch’s two-sample t-test).

Conclusion

There is an increased pDC in the TME of smokers’ lung cancer, and the response of pDC to DNA damaging treatment would lead a conducive environment to ICIs containing regimens. These findings suggest that R&D that induces an increase in the activated pDC population is continuously required to enhance therapeutic effectiveness of ICIs-containing therapies in lung cancer.