bluuebunny/crossref_metadata_2025 huggingface dataset:
Factores que afectan la suficiencia e interpretación de la citología de cuello uterino
Authors: Reyna Villasmil Eduardo , Mejia Montilla Jorly , Reyna Villasmil Nadia , Torres Cepeda Duly , Fernández Ramírez Andreina
Published: July 2022

Objetivo: evaluar los factores que afectan la suficiencia e interpretación de la citología de cuello uterino. Materiales y métodos: estudio transversal y retrospectivo en el Hospital Central “Dr. Urquinaona”, Maracaibo, Venezuela con la revisión de las historias clínicas e informes de las citologías de cuello uterino de la consulta de ginecología y obstetricia de enero a diciembre 2019. Se analizan las características generales y la clasificación de los informes (satisfactorios para la evaluación, satisfactorios pero limitados por y no satisfactorios). Resultados: se seleccionaron 581 informes de los cuales 329 (56,6%) eran muestras satisfactorias, 233 (40,1%) satisfactorias pero limitadas y 19 (3,3%) insatisfactorios. El análisis univariante demostró que la muestra insatisfactoria, la presencia síntomas al momento de la toma y el tipo de método anticonceptivo fueron factores que se asociaron significativamente (p < 0,0001). Los que influyeron para un resultado anormal de la citología cervical fueron frotis satisfactorio (razón de probabilidad, 4,78; intervalo de confianza del 95%, 3,127-8,136) y presencia de síntomas (razón de probabilidad, 11,652; intervalo de confianza del 95%, 2,992-38,55). Esta asociación continuó siendo significativa luego de ajustarlos a los factores de edad, paridad, edad al momento de la toma de la primera citología y método de anticoncepción (p < 0,0001). Conclusión: la suficiencia de la muestra de citología es un factor importante para la detección de anomalías celulares de cuello uterino y evitar resultados falsos negativos, retrasando la detección del cáncer.
Manejo de la nefropatía membranosa idiopática con ciclofosfamida endovenosa
Authors: Rosselli SanMartin Carlos , Vallejo Castillo Camilo Alfonso , Pérez Hugo Enrique
Published: July 2022

Introducción: las enfermedades glomerulares primarias ocupan la tercera causa de enfermedad renal crónica, siendo el origen más común de síndrome nefrótico en Colombia la nefropatía membranosa (NM). El tratamiento de la NM con ciclofosfamida endovenosa es una opción terapéutica, que no ha sido descrita en nuestra población. Objetivo: determinar la respuesta al tratamiento con ciclofosfamida endovenosa en la NM idiopática en el Hospital de San José de Bogotá en el periodo enero 2000 a enero 2019.  Metodología: estudio tipo serie de casos donde se incluyeron todos los pacientes adultos con diagnóstico de NM idiopática por biopsia renal tratados con ciclofosfamida endovenosa en el periodo descrito Resultados: ocho pacientes se incluyeron en el estudio de los cuales 50% eran mujeres, la mediana de edad de presentación fue 32,5 (RIQ:26-45) años. El 100% de los pacientes presentaron remisión parcial o completa, distribuidos así: 62,5% completa y 37,5% parcial. La mediana en el aumento de la tasa de filtración glomerular posterior al uso de ciclofosfamida endovenosa fue 9 (RIQ: 1-20,2) mL/min/1.73 m2. La sobrevida renal fue 100% y el porcentaje de recaída 12,5%. Conclusiones: el uso mensual de ciclofosfamida endovenosa es una opción en el manejo de la NM idiopática con un porcentaje de remisión parcial o completa de 100%, utilizando una dosis mediana acumulada de 93 (RIQ: 65,6-125) mg/k.
Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
Authors: Miño Bernal Jorge Fernando , López Morales Edna , Sandino Nelly Jazmín , Molano Franco Daniel
Published: July 2022

La cirrosis se considera el estadio crónico e irreversible de la lesión hepática. Su etiología es diversa y abarca causas como las infecciones víricas, tóxicos como el alcohol, medicamentos, patologías autoinmunes y otras. La descompensación de la cirrosis hepática es consecuencia de cambios fisiopatológicos que se dan con el tiempo como ascitis, peritonitis bacteriana espontánea, hemorragia del tubo digestivo, síndrome hepatorrenal, encefalopatía hepática o hipertensión portopulmonar, mientras que la falla hepática crónica agudizada debe considerarse como una entidad que debe diferenciarse de la anterior, ya que es una falla multiorgánica de curso rápido, por lo regular en pacientes hospitalizados en unidad de cuidado intensivo, a menudo secundaria a desencadenantes como estados de choque. El clínico debe identificarlas para su abordaje y evaluación. El método actual adecuado para estadificar esta entidad es el puntaje CLIFF SOFA, que evalúa la mortalidad a 28 y 90 días, permitiendo intervenciones adecuadas en cada caso.
Terapia de reemplazo renal, una alternativa para la calidad de vida de los pacientes
Authors: Morales Montoya Alejandra , Martínez Sánchez Lina María
Published: July 2022

La enfermedad renal crónica es una patología causada por la pérdida del funcionamiento del riñón con una filtración glomerular alterada por más de tres meses, por lo que es necesario recibir terapia de reemplazo renal consistente en la sustitución de esta función mediante la extracción de líquidos de la sangre y su filtración a través de membranas semipermeables, en especial para mantener la homeostasis mediante la eliminación de sustancias tóxicas nitrogenadas y desechos acumulados. Estos procedimientos y en particular la hemodiálisis pueden presentar diversas complicaciones debido a que son procesos invasivos. Cabe mencionar que los pacientes en terapia de reemplazo presentan una disminución de la calidad de vida sobre todo a nivel físico y psicológico, a costa de mantener una mejor condición de su salud renal.
Conocimiento de los residentes de especialidades médico-quirúrgicas en Colombia acerca del estado epiléptico
Authors: Vergara Aguilar Jean Paul , Palacios Sánchez Eduardo , Dueñas Garcia Friedrich , Cuesta Gutiérrez Arlene , Ortega Hernández Leslie , Vera Vega Omaris , Leal Castaño Luisa , Alzate Granados Juan Pablo
Published: July 2022

Introducción: el estado epiléptico es una emergencia con serias implicaciones a nivel social y económico, cuando no se maneja de manera adecuada puede llevar a la muerte. Debe abordarse por el primer especialista que tenga contacto con el paciente. En Colombia no hay estudios acerca de la adherencia a guías de práctica clínica. Objetivo: evaluar cuál es el conocimiento acerca del estado epiléptico en residentes de especialidades médico quirúrgicas en Colombia. Métodos: estudio de corte transversal descriptivo. Se aplicó una encuesta por medio de formulario google, diseñada con base en las guías de práctica clínica rutinaria para el manejo de esta patología. Resultados: respondieron la encuesta 76 residentes de neurología, medicina interna, medicina de urgencias y cuidado crítico, la edad más frecuente fue 26 a 31 años, con una relación hombre mujer de 46/54%. Discusión: las preguntas concernientes a las definiciones operativas y a los tiempos de acción fueron las que tuvieron una mejor consistencia al responderse, hay una importante falencia en la selección y uso de medicamentos anticrisis en el contexto del estado epiléptico, por lo que es importante fortalecer la educación médica en éstos aspectos académicos.
¿Conoce la semiología de la Cadera?
Authors: Rodriguez Moreno Hugo Armando
Published: July 2022

La necesidad de mejorar las competencias de los futuros profesionales en salud ha conducido a repensar la manera como se imparten los conocimientos a los estudiantes y de cómo ellos podrían aprender de manera significativa. Actualmente, el aula invertida (AI) o flipped classroom (FC) se convierte en una estrategia de enseñanza alternativa en el campo de la educación en salud. Incentiva el aprendizaje del estudiante al promover la autonomía en el abordaje de los conocimientos antes de cada clase, favorece la motivación, el aprendizaje activo, colaborativo y significativo durante las sesiones presenciales, de tal manera que permite desarrollar el pensamiento crítico para una formación profesional idónea. Al realizar una revisión de la literatura se evidenció un amplio uso del AI en educación en salud con resultados positivos frente a la educación tradicional. Además, las tecnologías juegan un papel importante para presentar contenidos y ejecutar actividades fuera y dentro del aula. Se presentan algunas evidencias de la efectividad del AI en educación médica, cómo podría implementarse en nuestras aulas y la diversidad de recursos disponibles para usar en los diferentes escenarios que plantea esta estrategia.
Cuidados de enfermería para reducir infecciones por microorganismos oportunistas en pacientes oncológicos
Authors: Castiblanco Montañez Ruth Alexandra , Garcia Murcia Juan Sebastian , Higuera Ramos Diana Mayerly , Morales Avila Mariana , Venegas Barrera Andrés Felipe
Published: July 2022

Introducción: las infecciones generadas por microorganismos oportunistas (MO) o infecciones oportunistas (IO) son causa importante de morbimortalidad en pacientes oncológicos y se les atribuyen factores relacionados con los cuidados específicos de la atención en salud. Las alteraciones en el sistema inmunológico, la multirresistencia antimicrobiana, la neutropenia febril y la interrupción de la integridad cutánea son los factores más influyentes. Objetivo: describir las principales intervenciones y estrategias para reducir IO en pacientes oncológicos. Metodología: revisión integrativa de la literatura. Se incluyeron artículos en español, inglés y portugués indexados a los tesauros MeSH Y DeCS, en las bases de datos CINAHL, Nursing Ovid, Clinicalkey; el metabuscador de Google académico y la interfaz Pubmed. Resultados: se revisaron 56 estudios, fueron organizados en tres temáticas: factores de riesgo que influyen para adquirir una IO en pacientes oncológicos, infecciones por MO y cuidados de enfermería, los cuales se agruparon en subtemas como: educación, medidas estándar, de barrera, farmacológicas, nutrición, manejo de catéteres, cavidad bucal, piel y aspectos emocionales. Discusión: se evidencian factores que influyen en la no adherencia por parte de los profesionales que están relacionados con sus posturas, el contexto social, el sistema sanitario y características de las GPC. Conclusión: fue posible describir las intervenciones y estrategias de prevención que permiten reducir de manera importante la morbimortalidad en pacientes oncológicos.
Enfermedad celíaca: un reto diagnóstico en Colombia
Authors: Suarez Correa Juliana , López Barreto Juan Camilo , Mejía Cardona Andrés Felipe , Paredes Fernández Antonio José
Published: July 2022

Introducción: la enfermedad celíaca (EC) es una patología sistémica inmunomediada por el gluten en la dieta en personas genéticamente susceptibles con un amplio rango de manifestaciones clínicas, respuesta serológica específica y daño variable de la mucosa intestinal. Objetivo: revisar la fisiopatología, manifestaciones clínicas, diagnóstico, tratamiento, seguimiento y pronóstico de la EC, resaltando la importancia de reconocerla y proponer un algoritmo diagnóstico para la población colombiana. Materiales y métodos: revisión crítica de la literatura científica en las bases de datos Medline y buscadores específicos PUBMED, SCIENCE DIRECT, SCIELO, filtrando resultados a revisiones sistemáticas, metaanálisis, ensayos controlados aleatorios, ensayos clínicos y guías, con un total de 1209 artículos, de los cuales se priorizaron 53. Resultados y discusión: la prevalencia de la EC viene en aumento en países en vía de desarrollo. El diagnóstico tiene tres pilares fundamentales: identificación de casos de alto riesgo o sospecha por manifestaciones clínicas, perfil serológico de anticuerpos específicos y hallazgos histológicos característicos. El tratamiento se basa en dieta sin gluten, detección temprana de complicaciones y manejo de las alteraciones nutricionales. Conclusión: en Colombia no existen protocolos de diagnóstico y tratamiento de la EC, como tampoco una legislación clara con respecto al etiquetado de productos libres de gluten. Hay que establecer estrategias para impactar el curso natural de la enfermedad, las morbilidades asociadas y la calidad de vida de los pacientes.
Quiste del rafe medio perineal
Authors: Oliveros Rivero Jorge Alejandro , Mendoza Vera Randy , Serrano Concha Karen Priscilla , Ocaña Dominguez Jorge Andrés , Ocaña Garcia Jorge
Published: July 2022

Introducción: los quistes de rafe medio (QRM) son lesiones infrecuentes del aparato genital masculino, pueden localizarse desde la parte distal del pene hasta la zona perianal. Se deben a defectos del cierre del rafe medio durante el desarrollo embrionario. Objetivo: presentar un lactante con el diagnóstico de QRM, discutir el diagnóstico, tratamiento y seguimiento. Caso clínico: niño de 1 año y 3 meses de edad con 7 lesiones quísticas de 0.5 cm cada una en el rafe medio escrotal desde el nacimiento, la ecografía de partes blandas reporta imagen sólida hipoecogénica de borde definidos y sin vascularización al doppler.  Se realizó exéresis quirúrgica y la patología confirmó el diagnóstico de quiste de rafe medio perineal, con buena evolución en el seguimiento. Discusión: 75% de los casos de los QRM son asintomáticos es por ello que muchas veces su diagnóstico es tardío, además su desconocimiento produce confusión con patologías quísticas o tumorales similares. El diagnóstico es clínico, aunque la ecografía puede ayudar para excluir otras anomalías como las vasculares. El tratamiento de elección debe ser la extirpación quirúrgica para evitar episodios de sobreinfección o molestias locales derivadas de su localización y tamaño. Conclusión: debido a lo infrecuente de esta patología es importante darla a conocer. Se recomienda realizar la valoración integral del paciente pediátrico para lograr un adecuado diagnóstico, ofrecer el mejor tratamiento y brindar información adecuada a los padres.
Análisis clínico e histopatológico de la prevalencia de enfermedades cardiacas en muerte súbita. Estudio en autopsias
Authors: Bonilla Jassir Juan Carlos , Parra Medina Rafael , Polo Nieto José Fernando , Rocha Aguirre Juan Eduardo , Téllez Rodríguez Juan Pablo , Cháves Juan José , Nieto Paula Daniela , Campuzano Larrea Oscar , Sarquella Brugada Georgia , Brugada Josep , Brugada Tarradellas Ramón
Published: July 2022

Introducción: un evento de muerte súbita supone un gran impacto para la sociedad, siendo importante su estudio para aportar conocimiento y fortalecer estrategias de promoción y prevención. Objetivo: determinar la prevalencia de los diagnósticos anatomopatológicos cardiacos definitivos y los hallazgos histopatológicos asociados con la muerte súbita de origen cardíaco en los pacientes sometidos a autopsias clínicas realizadas en el Hospital de San José de Bogotá DC, Colombia, durante el período 2015 a 2018. Métodos: estudio descriptivo de corte transversal retrospectivo en pacientes a quienes se les realizó autopsia con diagnóstico de muerte súbita de origen cardiovascular en el servicio de patología del Hospital de San José, Bogotá DC, Colombia. Resultados: se incluyeron 178 autopsias con diagnóstico de muerte súbita cardíaca. El promedio global de edad fue 56.1 años (DE: 15.06) con una relación hombre-mujer de 3:1. El hallazgo macroscópico más frecuente fue cardiomegalia (promedio 428.1 g (DE 112.8), acompañado de la presencia de coronariopatía esclerótica (p=0.000) con obstrucción de la luz de las arterias coronarias mayores de 80% (p=0.037). Conclusiones: los diagnósticos anatomopatológicos definitivos prevalentes en la muerte súbita cardiaca fueron cardiopatía isquémica crónica complicada (65%) e infarto agudo de miocardio (16%), datos similares a los reportados a nivel mundial. La cardiomegalia es un hallazgo frecuente que debe valorarse en forma cuidadosa.
Dr. Manuel Roberto Palacios Palacios
Authors: Arismendy Rodriguez Jeyson Leonardo
Published: July 2022

Hacer un extenso panegírico de su prolífica y exitosa carrera profesional y logros personales, obligaría a este su amigo y admirador a extenderme merecidamente para resumir todo lo que alcanzó este gran Señor, un verdadero caballero a carta cabal y quién siempre se distinguió por sus buenos modales y comunicación amable, cariñosa y asertiva. Nunca faltaron sus palabras de aliento, consejos desinteresados y apoyo incondicional a sus colaboradores y amigos por difíciles que fueran las circunstancias; este será su inmenso legado y por ello lo recordaremos y extrañaremos con inmenso cariño.
THE ROLE OF DIGITAL MARKETING FOR THE INDONESIAN INCLUSIVE BOARDING SCHOOL
Authors: Awang Saputra  , Muhamad Fauzi
Published: July 2022

Providing wholehearted service to students with special needs is a noble challenge, and the presence of the extraordinary school is an equal education effort in Indonesia. This study aims to determine digital marketing management in inclusive education. The research method is qualitative with the type of literature study. The study found that digital marketing is coordinated by a public relations representative, involving all teachers so that they are not seen as inclusive and equal to other schools. Students with special needs who live in boarding schools receive more religious lessons and skills assignments as additional activities in addition to regular study. Parents feel calm and comfortable if their children participate in activities in boarding schools so that they can interact and communicate more with their friends. Inclusive education services demonstrate independence and build community trust to meet student needs. Muhammadiyah association can provide educational institutions with the best services for students with special needs is a command in Islam.
Confirmatory model of risk perception in the Covid-19 era
Authors: García Lirios Cruz , Celia Yaneth Quiroz-Campas  , Javier Carreón-Guillén  , Francisco Espinoza-Morales  , Alejandra Navarrete Quezada
Published: July 2022

Treatment adherence is a central axis in the health agenda. In the framework of the SARS CoV-2 pandemic, it is necessary to predict this phenomenon. The objective of the present work was to contrast a model of structural equations. A confirmatory, psychometric and cross-sectional work was carried out with a selection of 100 students, considering their participation in the social service and professional practices in public hospitals in central Mexico. A factorial structure was found that explained 62% of the total variance, suggesting the contrast of the model in other scenarios.
Biogenic Synthesis and antibiofilm efficacy of iron nanoparticles via computer simulation
Authors: De Sousa Filho Walter Paixão , Zancan Tonel Mariana , Rodrigues Oviedo Vinícius , Da Silva Fernandes Liana , De Souza Diego , Rorato Sagrillo Michele
Published: July 2022

The search for new drugs can be accelerated by in silico methods, i.e., fully computational methods known for their speed and low cost, allowing the analysis of a large amount of data, e.g., thousands of possible antimicrobials, in a few weeks. Molecular docking and first-principles calculations are great allies in this quest. They enable the assessment of protein-ligand interactions and can predict interactions between NPs and macromolecules to provide more information about the interactions and dynamics of NPs in biological systems. In this context, this work aims to use in silico methods to detect the formation of biogenic metallic nanoparticles from functional microalgal biomolecules of the genus Chlorella, which have chelation of metal ions as a fundamental property, and to verify the possible antibacterial biofilm efficacy using computational tools such as molecular docking. In a first analysis, it was found that the iron salt FeSO4 was the most suitable to bind the microalgal enzyme and produce its phytochelatin protein. Following this result, an analysis of the electronic structure of the phytochelatin complex with the iron salt was carried out, proving its structural modification at the nanometric level, after which an analysis of its therapeutic effect on antibiofilm activity was performed. S. aureus, a bacterium known for its multiresistant to antibiotics, these results demonstrate, through alternative in silico methods, the physiological role of phytochelatin from microalgae in the detoxification and bioremediation of metallic contaminants.
Analyze of the impact of education spending on economic growth in Senegal from 1998 to 2017
Authors: Gueye Moussa
Published: July 2022

The objective of this article is to analyze the impact of education spending on economic growth in Senegal from 1998 to 2017. This study was based on an econometric modeling that showed that spending on Education positively influences economic growth captured by Gross Domestic Product (GDP). In fact, the results of the regression revealed that the increase in public spending on education by 1% leads to a 3% increase in economic growth in Senegal for the period 1998-2017. Education spending has a positive impact on economic growth.
EVALUATION OF THE EFFICIENCY OF NASOGASTRAL NUTRITION IN PATIENTS WITH SEVERE ACUTE PANCREATITIS
Authors: Kolosovych I.V. , Hanol I.V.
Published: July 2022

Relevance. Early onset of enteral nutrition (up to 48 hours after hospitalization) in patients with severe acute pancreatitis is associated with a 24% reduction in infectious complications and a 32% reduction in mortality. Data on the possibility of nasogastric tube feeding remain contradictory.

Objective: comparison of the effectiveness and safety of nasogastric administration of food mixtures in patients with severe acute pancreatitis.

Methods. The study included 103 patients with severe acute pancreatitis, which were divided depending on the characteristics of the chosen treatment tactics into three groups: based group (nasogastric nutrition was performed) - 34 patients, comparison group #1 (standard enteral nutrition) - 33 patients and comparison group #2 (parenteral nutrition) - 36 patients. To analyze the effectiveness of nutritional support in the study groups after 7 and 14 days from the beginning of treatment, the level of laboratory parameters was assessed, the incidence of local complications, mortality, duration of multiorgan failure and hospital stay were analyzed.

Results. After 7 and 14 days of nutritional support, a significant difference was found between total protein, albumin, creatinine, urea, cholesterol, glucose and serum Na + (p<0.05) between patients in the main group and comparison group #2, with the level of cholesterol, K + and Na + corresponded to the norm in both groups. There was also a significant difference in the incidence of infected local complications of severe acute pancreatitis in the main group and comparison group #2 - 35.3% and 61.1%, respectively (χ2=4.59, 95% CI 2.43-45.53, p=0.03), duration of multiorgan failure - 12.2±1.7 [8-16] days and 15.3±1.1 [13-18] days, respectively (p<0.001), duration of hospital stay - 55.5±30.5 [27-124] days and 71.5±35.9 [35-148] days, respectively (p=0.04) and fatalities - 14.7% and 36.1%, respectively (χ2=4.13, 95 % CI 0.81-39.68, p=0.04). When comparing these indicators between the main group and the comparison group #1 no significant difference was obtained (p>0.05).

Conclusions. Nasogastric nutrition is an effective and safe method of administration of mixtures in patients with severe acute pancreatitis and can be considered as an alternative to enteral nutrition.
PRE-AUTHORIZATION OF ANTIBACTERIAL DRUGS IN THE TREATMENT OF CHILDREN WITH ACUTE PERIANAL ABSCESS
Authors: Khaitovych M.V. , Kysil N.P. , Temirova О.А. , Holovnia O.M. , Turchak D.V. , Polovynka V.O.
Published: July 2022

Relevance. Acute perianal abscess mainly occurs in boys in the first year of life, but can occur in girls and in older age, often progressing to anal fistula. After surgery and drainage, it is advisable to administer antibiotics because antibiotic therapy reduces the risk of fistula.

Objective is to evaluate the possibility of using antibacterial drugs, mainly Access and Watch groups with a narrow spectrum of action, in the treatment of children with perianal abscess.

Materials and methods. A retrospective analysis of the results of treatment of 26 boys and 4 girls aged 3 months to 17 years. The study of biological material was performed by the culture method. Species identification of microorganisms was performed on automatic microbiological analyzers Vitek2Compact (bioMerieux) and VitekMS (bioMerieux). All children underwent surgical removal of the crypt and drainage of the abscess. Antibacterial therapy was prescribed for a period of 3 to 12 days, depending on the course of the disease and the results of microbiological monitoring.

Results. A total of 48 prescriptions of antibacterial agents were made, of which 33 (68.7%) were antibacterial agents from the Access group. 16 children were treated only with Access group antibacterial drugs. Of these, 14 children, mostly in the first year of life, received only narrow-spectrum antibacterial agents (amikacin in monotherapy or in combination with metronidazole, clindamycin). In the scheme of treatment of children 14 children, mostly older people included a drug from the group of cephalosporins of the third generation. Half of these patients also received amikacin and 3 received metronidazole.

Conclusions. Children with acute perianal abscess in the first year of life should be treated as mono- or combination therapy with narrow-spectrum drugs from the Access group, while older children - with the inclusion of a combination of antimicrobial drugs broad-spectrum drugs Watch group.
CARDIOVASCULAR SYSTEM INJURIES IN PATIENTS WITH COVID-19. Review
Authors: Moskalyuk V.D. , Randiuk Yu.O. , Syrota B.V. , Balanyuk I.V.
Published: July 2022

Relevance. The outbreak of new coronavirus disease (COVID-19) caused by SARS-CoV-2 is the biggest medical problem of the 21st century.

Every year, humanity is faced with new diseases of viral etiology, the unpredictable occurrence and severe manifestations of which often lead to the stupor of scientists and physicians around the world. Although the virus primarily affects the lungs, and the clinical manifestations of the disease are dominated by respiratory symptoms, but it significantly affects the risk of development and clinical course of cardiovascular disease. It should be noted that heart disease with COVID-19 can be observed in patients with chronic diseases of the cardiovascular system, as well as in patients who had no signs of heart disease before this infection.

Objective: to consider current data on cardiovascular disease in patients with COVID-19.

Methods. Analysis of latest data presented in PubMed by keywords "COVID-19", "SARS-CoV-2", "pandemic", "cardiovascular disease", "myocardial infarction". Search depth – 2 years (2020-2022), with retrospective deepening of some positions until 2003.

Results. Coronavirus interacts with the cardiovascular system on many levels, increasing the incidence of patients with concomitant cardiovascular disease and provoking myocardial damage and dysfunction. In addition, cardiovascular disease in patients with coronavirus disease may pose an increased risk of mortality. Therefore, an understanding of the damage to SARS-CoV-2 to the cardiovascular system and its underlying mechanisms is of the utmost importance to ensure that the treatment of these patients is timely and effective and that mortality is reduced.

Conclusions. COVID-19, caused by SARS-CoV-2, is a global pandemic that is evolving in real time. Concomitant cardiovascular disease is common in patients on COVID-19, and these patients have a higher risk of morbidity and mortality. Therefore, in addition to routine examinations for coronavirus disease, patients with cardiovascular disease should receive ancillary studies of the heart and blood vessels, such as cardiac biomarkers, cardiac imaging, electrocardiography, echocardiography and angiography.
Perancangan Alat Pemotong Tulang Daging Dengan Chainsaw Skala Industri Rumahan
Authors: Saragih, M.Sc., Ph.D Albert Daniel , Aliftyo Muhammad Rifqi , Mulyana Deni
Published: July 2022

The technique of bones saw was used by many traders still uses the conventional method, namely with a butcherknife. To make cutting more efficient, bone saw machines are created which are widely marketed. However, the use of thesetools is considered inefficient because during operation the meat attached to the bones will move into the machine through thecutting tool so that the motor work becomes heavy and even the cutting tools are prone to breaking, then the electrical powerrequired is large enough to make traders use more conventional methods. This manufacturing technique aims to producedesigns and working drawings of meat bone cutting machines and the components needed. Bone cutting machines are designedto be used by various groups of bone traders, market traders or home-based traders to increase production and use low electricalpower. The machine was designed to be more efficient than the previous by modifying the cutting tool using a saw type,namely a chainsaw with a low electrical power of 550 Watt or equivalent to 0.75 HP and a blade speed of 2500 rpm. Themachine was designed to use a spring to raise the machine automatically. The dimension of 800 mm × 700 mm × 1415 mmhas double safety that is protected by a cover and a lever to provide distance between the machine and the operator.
Effect of Cold Plasma Treatment on Physical Properties of Multilayer Plastics for Polymer Asphalt Applications
Authors: Setiaji Dimas Agung , Chalid Mochamad , Abuzairi Tomy , Efroza Maurice , Nugraha Adam Febriyanto
Published: July 2022

Multilayer plastic waste continues to increase due to the ever-growing consumption and needs of the global citizen and is one of the most challenging types of waste to recycling because of its nature. The accumulation and indiscriminate disposal of waste can pose a potential risk of environmental problems. A solution that can be implemented is to mix bitumen and waste polymer as asphalt manufacturing. Despite its advancement in research, many potential parameters are still to be discovered to achieve optimal results. Through cold plasma treatment, a surface treatment may occur at the multilayer polypropylene that causes the change from hydrophobic to hydrophilic properties. Treating the polymer with cold plasma will provide good hydrophilic properties without changing the overall chemical and thermal properties of the sample. This will result in an alternative aggregate for the bitumen for asphalt manufacturing. Bitumen coupled with the addition of plastic still provides an optimal hardness and ductility, meanwhile having a more economically viable manufacturing process than other processes.
Analisa Material Rumah Kopling Motor Matik Dengan Penambahan Luas Bidang Pendingin
Authors: Rohmat Nur
Published: July 2022

: Pemindahan daya mesin keroda belakang motor matic menggunakan teknologi transmisi otomatis (continousy variable transmition / CVT). Kendala umum yang terjadi pada transmisi otomatis salah satunya adalah drum koplingnya aus, sehingga kopling bergetar dan saat idlle roda belakang masih bergerak. Kerusakan yang terjadi drum kopling diantaranya:  terkikis, kopling tidak center dan abrasive pada area gesekan antara drum kopling dengan sepatu kanvas. Metode penelitian dengan pengamatan secara visual pada perubahan bentuk drum kopling dan perubahan sifat mekanis material drum kopling melalui uji laboratorium. Kesimpulan Pengujian material melalui pengujian:  komposisi kimia, uji kekerasan dan uji metalografi. Kesimpulan dari penelitian drum kopling, yang ditambahkan lubang tidak banyak mengalami perubahan dari drum kopling yang dibandingkan dengan drum kopling baru, baik kekerasan material, ukuran dimensi, struktur mikro dan suhu yang memikiki perbedaan  dibandingkan dengan drum kopling yang tidak ditambahkan lubang pendingin.
Menggunakan Paradigma Studi Kasus Kualitatif Interpretatif Online dan Offline Untuk Memahami Efektivitas Penerapan E-Procurement
Authors: Nurdin Nurdin , Pettalongi Sagaf S.
Published: July 2022

The presence of social media allows researchers to consider new data collection and triangulation strategies. Positivist researchers take advantage of the internet's presence as a medium for collecting data. Meanwhile, interpretive qualitative researchers have not utilized the potential provided by social media to enrich data collection in order to deepen understanding of a topic being researched. By using the case of the effectiveness of the application of e-procurement in a district, the researcher conducted face-to-face interviews (offline) and also observed discussions on social media and content sharing about the implementation and use of government e-procurement in a district. This study uses an interpretative qualitative paradigm to describe how social media exchanges, uploads, and conversations can be used as a means of collecting data in interpretive qualitative research. The results of this study indicate that social media observation can be used as a research tool to increase understanding of a topic being studied and also as a triangulation medium. This study also proves that the use of social media in interpretive studies can reduce challenges in informant recruitment, access to research sites, and reduce bias in interviews. This research contributes to the understanding of a research topic using data from two environments.Keywords:Social media, interpretif study, e-procurement effectiveness, research paradigm
Implementasi Manajemen Rantai Pasok pada Industri Kue
Authors: Kalifatullah Ermaya Sir , Mulyana Iwan , Nur Laela Ermaya Husnah , Nurwati Ucu
Published: July 2022

This research is entitled "Implementation of Supply Chain Management in the Cake Industry (Case Study at Eti Snack, Kalipucang)". The writing of this research is motivated by several obstacles that are often experienced by companies. This study uses a descriptive method with a qualitative approach. The respondents consisted of the owner and five employees. The results show that: the company has implemented a supply chain management system well, suppliers are the key for the company in the sustainability of the production of various kinds of cakes, accuracy in distribution and quality of raw materials affect cake production which has implications for the quality of consumer value, and distributors act as mediators in success. the company sells products mainly for pastries. For all of this, the company is expected to continuously improve its capabilities so that it has a sustainable competitive advantage.
Analisis Strategi Pemasaran pada Kerta Cafe dalam Upaya Memulihkan Ekonomi Pasca Pandemi Covid-19
Authors: Haris Fadhillah Muhammad , Solihin Shofwan Azhar , Nugrahyani Defitri
Published: July 2022

The purpose of this research is to analyze marketing strategy for competitive advantage. The method used in this research is SWOT analysis to examine alternatives of strategies to be applied. The results of SWOT analysis in Kerta Cafe is aggressive strategy, the right alternative strategy is SO strategy that allows Kerta Cafe to use all of its strengths maximally to make the most of opportunities.
Profil Keputusan Struktur Modal Pelaku Usaha Mikro, Kecil Dan Menengah
Authors: Kelen Lusianus , N. R. Hutar Alliny , D. Adindarena Vindya , R. Renggo Yuniarti
Published: July 2022

Research on capital structure so far has often been studied in the context of large companies and there are still few studies that explain it in the context of Micro, Small and Medium Enterprises (MSMEs). Not only that, research on capital structure has so far been dominated by research with a regression-based model and focuses on business characteristics, not individuals. In addition, the development of capital structure in Indonesia is also dominated by research from Java. This has become the author's interest in researching the capital structure of MSMEs in areas outside Java, more precisely in East Sumba Regency, East Nusa Tenggara Province (NTT). By using quantitative descriptive data analysis techniques on 208 samples of actors as long as MSME owners in East Sumba Regency, the results show that the capital structure decision profile of MSME actors in East Sumba follows the pecking order theory pattern, where MSMEs prioritize internal funding over external funding. However, this theory is not the only one in explaining the profile of capital structure decisions, because the trade-off theory is also illustrated even though the percentage is small.
Pathogenetic aspects of retroviral infections
Authors: Horalskyi L. P. , Sokulskyi I. M. , Gutyj B. V. , Goralskaya I. Y. , Kolesnik N. L.
Published: July 2022

Bovine leukemia and equine infectious anemia are registered in most regions of Ukraine and in many countries worldwide. This is accompanied by economic losses and reduced quality of livestock products, which determines the relevance of the study of retroviral infections, their diagnosis, and pathogenesis. The goal of our research was to find and improve the methodological foundations of the development of the pathological process for a more in-depth study of the etiology, pathogenesis, treatment, and prevention of retroviral infections. The object of the study was blood, lymph nodes, spleen, heart, lungs, liver, and kidneys for bovine leukemia and equine infectious anemia. Hematological, anatomical, histological, histochemical, morphometric, and statistical research methods were used for their study. The research group included 304 cattle aged 4–9 years and 42 horses, of which 25 were infected with the virus, and 17 were in the control group. It has been established that bovine leukemia and infectious anemia of horses is an irreversible pathological process characterized by slow progression, the presence of a latent or persistent form, with damage to cells, organs, and systems of the body, which leads to death. Infectious anemia of horses differs from leukemia of cattle by the hidden course of the pathological process. The pathogenesis of leukemia occurs in six stages, which we have identified and conventionally named.
The Russian Civil War in the Collective Memory of Russian Society
Authors: BARANOV Andrey
Published: July 2022

In October 2022, it will be 100 years since the Russian Civil War of 1917-1922, which largely changed the fate not only of Russia, but also of the whole world and caused considerable human and economic losses to the country. The Civil War strengthened radical sentiments within the Russian society, led to hardening the authoritarian regime and divided the Russian nation on ideological grounds. The article, based on materials of sociological and ethnographical studies of the 2000s-2020s, examines the memory/oblivion and perceptions of the Civil War in nowadays Russian society in general and in the Southern Federal District of Russia in particular. The author seeks to determine factors for achieving national reconciliation and regulating identity conflicts in plural societies on the example of Russia. He points to the growing simplification of the Civil War image since the 2000-s and to the prevalence of mythologized stereotypes, as a result of generational change together with the spread of digital media and non-professional narratives. The memory of the Civil War has been manipulated by public figures, media, activist groups, for instance the Cossack movement, in order to “reformat” the picture of the historical past according to their own paradigms. The image of the Civil war is being fragmented, deprived of contents accepted and shared by all. This alarming situation requires professional efforts to educate citizens in history and to achieve civic cohesion and solidarity.
Land of Controlled Neo-Nazism
Authors: ANANIEVA Elena , ANANIEV Aleksandr
Published: July 2022

Russia's special military operation in Ukraine once again requires revisiting the course of events on the Maidan in 2013-2014. The facts allow not only to reproduce the sequence of actions of the opposing parties, but also to establish the true causes and consequences of what happened, the foreign actors and the background of the Ukrainian crisis - the most significant international crisis since the end of the Cold War. The authors offer an answer to the question whether the 2014 Maidan events were a "revolution of dignity" or an illegal coup d'état, which imposed a radically nationalist scenario to the country, and consider the relevancy of the term "neo-Nazism" to the realities of post-Maidan Ukraine.
The Czech Republic and the Ukrainian crisis: Economic and foreign policy aspects
Authors: ZEMÁNEK Ladislav
Published: July 2022

The article deals with two areas: first, the consequences of the 2022 Ukrainian crisis for the Russian business in the Czech Republic and the Czech business in Russia; second, the accelerating dynamics of the Czech-US relations, which are increasingly intensive, primarily in the field of the (geo)political and military cooperation. The analysis shows that the liberal elites are deepening the country's Euro-Atlantic orientation, which manifests itself both at the conceptual, ideological and practical levels. Not surprising in this context are the attempts to revive the plans to establish a US military base in the Czech Republic and Prague's active military support for Kiev to the detriment of the national interest. The study reveals a strong tendency among the Czech political elites towards militarism and revision of policy fundamentals in line with radical Euro-Atlanticism and liberal authoritarianism.
Cyclical Patterns of Globalization Processes
Authors: TRAVKINA Natalia , VASILIEV Vladimir
Published: July 2022

The beginning of Russia's special operation in Ukraine at the end of February 2022 has been a powerful catalyst, both in the USA and in other countries of the "collective West", for a noteworthy number of theoretical works and journalistic essays on the theme of the inevitable end of globalization, at least in the forms in which globalization has manifested itself since the early 1990s, that is, for the last 25 - 30 years. Apocalyptic forecasts about "the end of globalization", which have replaced theoretical constructs in line with F. Fukuyama's optimistic "end of history", impose to look at modern globalization processes in a broader historical context. The formation of the world economy and scientific and technological progress – both in past historical periods, starting from about the last third of the ninetieth century, and nowadays – have generated and are generating wave-like globalization processes, which are based on a number of clearly identifiable patterns.
Challenges facing Iraq's accession to the World Trade Organization
Authors: Ghaidan Jalil Kamal , Kabbashi Rawahel Ali Talei
Published: July 2022

Iraq is one of the countries that applied for membership and was approved for observer status in the organization in 2004. Iraq suffers from distortions in the structure of the economy as a result of wars and the destruction that has befallen it, which requires Iraq to carry out a package of economic reforms in order to address the reality of the Iraqi economy and its integration with the global economy, which requires preparation for planning that is compatible with the requirements of accession to the World Trade Organization. The study aims to present a theoretical framework for the services sector and to, identify its most important main components and shed light on the reality of services in Iraq and the extent of their development as well as their general trends, using multiple economic indicators and knowledge of the most significant obstacles that stand in the way of Iraq’s accession to the World Trade Organization and overcoming these obstacles in light of the reality of the economy Iraq, and utilizing what results from the services sector in the possibility of achieving economic development for Iraq after its accession to the World Trade Organization. And that one of the most important findings of the study is that the World Trade Organization is one of the most important international organizations concerned with international trade affairs and plays a prominent role in facilitating international trade and is interested in removing obstacles that hinder the flow of trade between member states, and it is a mechanism for resolving disputes between countries, and this It has become a reality, so it is necessary to join the other countries in order to complete the development process in light of joining the ranks of the member states.
Efeito da frequência alimentar sobre o crescimento do lambari, astyanax bimaculatus (Characiformes, Characidae)
Authors: Santos Ricardo Pinto dos , França Caroline Lopes , Sousa Wanderson Diego Reis , Silva João Mandú da , Pinheiro Thiago Ferreira , Teixeira Erivania Gomes
Published: July 2022

O lambari, Astyanax bimaculatus, é uma das espécies nativas com potencial zootécnico para a aquicultura, e se destaca com características desejáveis para o cultivo, logo, estudos referentes à quantidade ideal de alimento são necessários para melhorar o desempenho zootécnico da espécie. Sendo assim, objetivou-se avaliar e descrever a influência da frequência alimentar sobre o crescimento do A. bimaculatus. Matrizes de A.bimaculatus foram capturadas em uma piscicultura maranhense, hipofisadas em laboratório com hormonôno sintético e em seguida casais foram estocados em sistema de desova semi-induzida. Após a eclosão as pós-larvas foram transferidas para um tanque berçário, para o treinamento alimentar com ração comercial durante 20 dias. Posteriormente os alevinos foram submetidos à biometria e transferidos para unidades experimentais com tratamentos pré-estabelecidos, com três diferentes frequências alimentares, sendo duas, três e quatros vezes ao dia, até a saciedade aparente, o monitoramento da água foi realizado semanalmente. Os resultados demonstraram que a alimentação natural juntamente com a ração comercial 45%PB influenciaram signficamente. Os parâmetros físico-químicos da água mantiveram-se dentro dos padrões aceitáveis para a espécie durante toda a pesquisa, e os índices zootécnicos apresentaram crescimento linear. Concluiu-se que o crescimento do A. bimaculatus é influenciado pela frequência alimentar. Considerando o ganho de peso, indica-se que os alevinos de A. bimaculatus podem atingir o melhor desempenho zootécnico quando alimentados quatro vezes ao dia. Ressaltando o favorecimento na conversão alimentar proveniente do aumento na frequência alimentar.