bluuebunny/crossref_metadata_2025 huggingface dataset:
An Implementation Pilot of Web-Based Self-Training Programs on Sexual Dysfunctions in the Dutch Public Sexual Health Setting: Mixed Methods Study (Preprint)
Authors: Zimbile Filippo , Beek Titia , David Silke , Crutzen Rik
Published: May 2023

BACKGROUND

Web-based sexual health interventions may be more acceptable to people compared with face-to-face support, given the stigma and embarrassment often associated with sexual problems. The Dutch public sexual health clinics (SHCs) conducted an implementation pilot with 4 web-based self-training programs on sexual dysfunctions (WSTPs) for young people. In addition to a basic sexuality program, the WSTPs focused on the following complaints: pain during intercourse, premature ejaculation, and no sex drive.

OBJECTIVE

This study aims to gain insight into the potential reach of the freely offered WSTPs; use, acceptance, evaluation, and perceived impact of the WSTPs by young people; and evaluation and acceptance of the WSTPs by nurses of the SHCs.

METHODS

A quantitative baseline measurement (BM) and a follow-up measurement (FM) were conducted among the users. In addition, qualitative data were gathered through video interviews with a sample of respondents of the FM and nurses of the SHCs to gain more in-depth insights into their assessment of the WSTPs. Participants were recruited via social media, posters, and referrals by nurses of the SHCs. Quantitative data were analyzed using descriptive statistics. Independent 2-tailed t tests and one-way independent ANOVAs were used to compare the scores between subgroups based on background characteristics. Dependent 2-tailed t tests were used to assess the possible changes between BM and FM. The interviews were analyzed using a thematic analysis.

RESULTS

A total of 1028 young people (aged 16-24 y) completed the BM, 666 started with 1 of the WSTPs, and 104 participants completed the FM. In addition, 8 users and 8 nurses were interviewed. Of the participants who completed the BM, 87.74% (902/1028) experienced moderate (411/1028, 39.98%) to high (491/1028, 47.76%) severity of complaints, of which 20.43% (210/1028) had had them for >1 year and 27.82% (286/1028) even for ≥2 years, and 38.91% (400/1028) were dissatisfied with their sex lives. Only 8.75% (90/1028) had sought professional help in the past 2 years. At FM, users rated satisfaction with their sex life more positively than they did at BM, and they experienced less discomfort from their complaints. The overall rating was positive, with a mean report grade of 7.3 (SD 1.45; on a 10-point scale). Anonymity, clear information and explanation, and practical exercises are indicated as strengths of the WSTPs, leading to more understanding and normalization. Nurses appreciate the high quality of information and accessibility of the WSTPs. They consider them as a valuable addition to the consultation hours.

CONCLUSIONS

WSTPs can reach a large number of young people with sexual problems who are less likely to seek professional help. This can result in an improved understanding of their issues, a decrease in complaints, and reduced barriers to communicating with a partner or professional.
Work Engagement Influences Affective Commitment: Psychological Capital and Perceived Organisation Support As Moderators
Authors: Lie Daniel , Saraswati Kiky Dwi Hapsari , Lie David Sugianto
Published: May 2023

Introduction/Main Objectives: It is well-known that millennials have low levels of attachment towards the organisation.It istherefore necessary to consider ways of retaining them as leavers may affect the organisation financially. Background Problem: Previous studies have consistently shown that work engagement (WE) significantly affects affective com­mitment (AC). However, the correlation level varies. Hence, a moderator could be affecting the strength of their relationship. Novelty: This research investigated whether psychological capital (PsyCap) and perceived organisation support (POS) could act as moderators. Research Methods: The research was a quantitative and non-experimental study. Researchers usingthe convenience sampling technique and the participants were 111 Indonesian millennial employees who completed questionnaires virtually. Findings/Results: Regression analysis confirmed that WE influenced AC significantly and PsyCap was shown to be a moderator. Further, a three-way interaction revealed that a low level of POS has a significant effect,but only when the level of PsyCap is low, implying that POS is still valid as a moderator (even though only partially). Conclusion: This study concluded that both PsyCap and POS are important for millennial employees. Therefore, it is recommended that management consider these two variables when managing the millennials in their organisation.
Some Particularities of the Use of Definite Articles in Proper Nouns (Antroponyms and Toponyms): A Semantic Approach in a Comparative Perspective Between Mozambican Portuguese and European Portuguese
Authors: Alfredo Rufino
Published: May 2023

The present work, entitled Some peculiarities of the use of definite articles in proper nouns (anthroponyms and toponyms): a semantic approach in a comparative perspective between Mozambican Portuguese and European Portuguese, has as main objective to analyze the use of definite articles in proper nouns ( anthroponyms and toponyms) in Mozambican Portuguese. In this sense, we try to describe the different contexts in which the presence/absence of definite articles in proper names (anthroponyms and toponyms) occurs in European Portuguese (EP), we also try to compare the use of definite articles in proper names (anthroponyms and toponyms) in Mozambican Portuguese (PM) with European Portuguese (PE). The study is of a descriptive nature and to carry out the data analysis, a written corpus was built that resulted from the application of two linguistic tests, namely a provoked production test (filling in empty spaces in Portuguese sentences), composed of thirteen ( 13) sentences and a test of grammaticality and/or acceptability judgments, consisting of twenty-six (26) sentences. The inquiry was directed to eighty (80) students of the 10th Grade of the Secondary School of Tete. The analyzed data allowed us to verify that in the variety of Mozambican Portuguese, speakers constantly omit the definite articles in sentences with simple anthroponyms in different positions and contexts, thus creating a difference with European Portuguese; they omit definite articles in contexts where simple toponyms occur (referring to place names that designate landforms), in a predicative syntactic position of the subject; in short, the study allowed us to verify several differences in the two varieties of Portuguese, with regard to the use and/or omission of definite articles in different contexts.
Kovai Spot Bus - Bus Recommendation System
Authors: Aruna Ms. T N
Published: May 2023

Abstract: Kovai spot bus is a real time project which is useful for the people who is the facing problems with the current manual work of bus searching. Kovai spot bus system contains all bus with their route details. The main purpose of this software is to reduce the manual errors involved in the travel process and make it convenient for the people to manage their bus details. This project has been made simpler and interactive. This is an android application used to find out the bus number from one place to another place. User need to give the details of source and destination.
Cybersecurity Enhancement of Transformer Differential Protection
Authors: R Sampath
Published: May 2023

Abstract: The increasing use of information and communication technologies (ICT) in the operational environments of power grids has been essential for operators to improve the monitoring, maintenance, and control of power generation, transmission, and distribution; however, this has come at the expense of increasing the grid's exposure to cyber threats. This paper looks at cyberattack scenarios that target protective relays in substations, which can be the most important part of protecting power systems from abnormal conditions. The overall performance of the power grid could suffer significantly if the relays' operations are disrupted, possibly resulting in widespread blackouts. Utilizing the potential of machine learning to detect anomalous behavior in transformer differential protective relays, we investigate methods for improving substation cybersecurity. In order to find cyberattacks, the proposed method looks at operational technology (OT) data from the substation current transformers (CTs). Power frameworks recreation utilizing OPAL-RTHYPERSIM is utilized to create preparing informational collections, to simulate the cyberattacks and to evaluate the network safety enhancement capability of the proposed AI calculations. Terms in the index include differential protective relays, transformers, operational technology, cyber physical systems, and machine learning.
Smart Irrigation System Using Moisture Level Sensor
Authors: C Arunkumar
Published: May 2023

Abstract: Farming is the cultivation of plants and livestock. Plant monitoring is one of the most important tasks in farming. The goal of this paper is to use IoT in the NodeMCU system platform for plant monitoring and smart gardening. The primary goal of this paper is to reduce direct interaction and provide comfort to the farmer by improving the system's overall performance. Humidity, sunlight, and soil moisture are important factors to consider when monitoring plant productivity. Plant growth and health information must be provided to the user on a continuous basis by monitoring and recording these parameters. The NodeMCU interfaces with all of the sensors used in this project. Farmers can use IoT to directly monitor and control plant information via their smart phones. By sensing and controlling the parameters of the plants without their physical presence, this smart plant monitoring system will provide the user with convenience and comfort. The smart plant monitoring application can be installed on any Android-enabled device. The software used is the Arduino IDE and the IoT platform. The Arduino IDE is used to compile and upload the programme to the NodeMCU, and the IoT platform is used to display temperature, humidity, atmospheric pressure, and soil moisture from a distance. This will assist the farmer in understanding the relationship between plant growth and mentioned plant parameter.
Design and Development of Cost-Effective 3D-Printer
Authors: H B Kishore Gowda
Published: May 2023

Abstract: The objective of this project is to design and develop a cost-effective 3D printer that can produce high-quality prints while minimizing the overall cost of the system. The project will involve researching and selecting components that provide a balance between cost and performance, including a suitable frame, motors, electronics, and hotend. The printer will be designed with a large build volume to enable printing of larger objects. The control system will be based on an open-source microcontroller, and software will be developed to optimize print quality and minimize material usage. Testing and calibration will be performed to ensure the printer can produce accurate and high-quality prints. The outcome of this project will be a lowcost 3D printer that can be used by hobbyists, students, and small businesses for a variety of applications, such as prototyping and product development.
Gesture Controlled Virtual Mouse using AI
Authors: B N Rekha
Published: May 2023

Abstract: This project offers a cursor controlsystem that quickly navigates system controls whileusing a voice assistant and a camera to record usermotions. Using the aid of MediaPipe, the user can control the computer cursor with hand gestures. It will perform actions like left clicking and draggingusing a variety of hand motions. Additionally, you have a choice to adjust the brightness, loudness, and a number of other things. The system is constructed using advanced Python packages like MediaPipe, OpenCV, etc. All i/o activities are physically controlled by a hand motion and a voiceassistance. The research uses advanced technologies like machine learning and computer vision techniques, which operates well without the use of any additional computer resources, to recognize hand movements and spoken instructions.
Research Paper on: Doctor Appointment Booking System
Authors: Wankhade Mr. Atharva S.
Published: May 2023

Abstract: A mobile application called "Health Care Application" is designed to make it easier for people to get medical help by giving them quick, accurate responses. Users of the health care application include doctors, patients, and vendors of medications, pharmaceuticals, and medical supplies. The 'Health Care Application' concept will provide users access to all the amenities whenever and wherever they choose, given the significant increase in the use of smartphones. In today's current, technologically advanced world, it is crucial to find a quick, digital solution to any issue, therefore any emergency needs must be met in an approachable manner. This programme has a symptom analyzer that analyses the symptoms entered by the patient and suggests medications or medical professionals based on those symptoms.Given howdifficult it is to remember everything in the modern world, the medication reminder helps users remember their medication dosages without forgetting any. Multiple types of accounts help to maintain data security by limiting user access to only that data for which they are authorised, so data integrity is highly valued. Additionally, this application has a chat room where users can consult doctors, avoid waiting in line at the clinic, pay with their wallets, and, if they choose, take advantage of health insurance services. The patient's health status can be live-monitored by the doctor, who can also review past medical records.
Smart Video Surveillance Using YOLO Algorithm and OpenCV
Authors: Sharma Anubhav
Published: May 2023

Abstract: Due to object detection’s close relationship with video analysis and image understanding, it has attracted much research attention in recent years. Traditional object detection methods are built on handcrafted features and shallow trainable architectures. Their performance easily stagnates by constructing complex ensembles that combine multiple low-level image features with highlevel context from object detectors and scene classifiers. With the rapid development in deep learning, more powerful tools, which can learn semantic, high-level, deeper features, are introduced to address the problems existing in traditional architectures.
Aplikasi Pembelajaran Benda-Benda Bersejarah Dengan Metode Lean Software Development
Authors: Nurfajar Rendra Eka , Rahardjo Rifki , Firdaus Achmad , Wahab Abdi , Mutu Manikam Ratna
Published: May 2023

Benda-benda bersejarah adalah peninggalan dari orang – orang terhadulu, yang dimana benda – benda tersebut memiliki nilai sejarah atau budaya yang ada di masyarakat. Karenanya benda – benda bersejarah cukup menarik untuk dipelajari. Penelitian ini dilakukan untuk mengidentifikasi peninggalan benda bersejarah yang ada di dunia serta memperkenalkan benda – benda bersejarah tersebut kepada masyarakat. Pada penelitian yang dilakukan sebelumnya telah dilakukan penelitian dengan menerapkan menerapkan metode Agile Extreme Programming (XP) pada Sistem informasi geografis tempat pariwisata bersejarah di wilayah bandar lampung. hanya saja, dalam penelitiannya lingkup yang ditawarkan sangat kecil mengingat objek sejarah yang ditunjukkan hanya untuk wilayah bandar lampung saja. Oleh karena itu kami akan menggunakan  metode agile  Lean Software Development (LSD) untuk mendapatkan hasil yang lebih baik mengingat ruang lingkup yang akan dibuat dalam penelitian lebih besar dari sebelumnya. Hasil dari penelitian ini menghasilkan sebuah aplikasi pembelajaran benda-benda bersejarah, dan setelah dilakukan pengujian mendapatkan hasil yang baik sesuai dengan skenario yang telah dibuat. Diharapkan aplikasi ini dapat dikembangkan ke arah perangkat bergerak agar lebih mudah diakses oleh khalayak umum lebih luas.
Educación de la primera infancia y lectoescritura emergente en Centroamérica y República Dominicana
Authors: Nanne Ingrid , Stone Rebecca , Vijil Josefina , Spier Elizabeth , Andrade-Calderón Paola
Published: May 2023

La educación durante la primera infancia es crucial para el desarrollo cognitivo, emocional y social de las personas y tiene un impacto de largo plazo puesto que, en los primeros años de vida, constituye un período de amplio crecimiento y evolución; en parte, por los numerosos cambios que se producen en el cerebro. La evidencia revela que los programas educativos de buena calidad son los que aprovechan las potencialidades de la edad infantil para desarrollar habilidades fundamentales para el aprendizaje a lo largo de la vida. Por ello, invertir en buenos programas de educación y cuido de la primera infancia debe ser parte de una base fundamental de las políticas y programas de desarrollo humano. Tener acceso a oportunidades educativas de calidad durante la infancia contribuye a mejorar la equidad social y a cerrar las brechas de desigualdad, especialmente en la niñez más desfavorecida. En esta investigación se define a la educación en la primera infancia como las etapas, niveles o programas de educación formal y no formal que se ofrecen a la niñez desde el nacimiento hasta antes de iniciar el primer grado de primaria.

Se han desarrollado numerosas investigaciones que dan cuenta de la situación internacional en la educación de la primera infancia y de las mejores prácticas con recomendaciones que enriquecen la toma de decisiones. Sin embargo, en Centroamérica y República Dominicana se carece de investigación que ofrezca un panorama regional del tema y evidencias que informen políticas específicas, de ahí la importancia de este trabajo.
Educación de la primera infancia en Centroamérica y República Dominicana: conclusiones de un estudio regional
Authors: Nanne-Lippmann Ingrid
Published: May 2023

Este artículo expone las conclusiones de la investigación sobre el panorama de la educación de la primera infancia en Centroamérica y la República Dominicana desarrollada por la Red para Lectoescritura Inicial de Centroamérica y el Caribe (RedLEI). Los programas educativos de buena calidad aprovechan las potencialidades de la edad infantil para desarrollar habilidades fundamentales en beneficio del aprendizaje a lo largo de la vida. Por ello es fundamental invertir en buenos programas de educación y cuido, en respaldo de las políticas y programas de desarrollo humano. Se presentan los resultados que buscaron responder la siguiente pregunta: ¿Cuál es la alineación entre la evidencia investigativa sobre la educación de la primera infancia con la política educativa de Centroamérica y la República Dominicana y su implementación? Se proponen los desafíos y oportunidades principales que emergen como problemas compartidos en la región en este ámbito y propuestas sugeridas desde los mismos países como potenciales soluciones.
LAYANAN BIMBINGAN KELOMPOK DENGAN TEKNIK SOSIODRAMA TERHADAP MOTIVASI BELAJAR SISWA KELAS XI DI SMAN 1 MANIIS PURWAKARTA
Authors: Parida Ida
Published: May 2023

The purpose of this study is to find out the implementation, response of teachers and students, student difficulties, and teacher difficulties of group guidance services with sociodramaic techniques to increase learning motivation. This research uses qualitative approaches as for the methods used that are descriptive. Data collection techniques are carried out through observation, interviews, and documentation. The research site is focused on class XI SMAN 1 Maniis Purwakarta. The subject of the study is to the guidance and counseling teacher and the student. Data analysis is done by selecting and sorting the answers to the data obtained and then collected for analysis and conclusions. The data analysis used is using data triangulation. Data validity tests use levels of credibility, transferability, dependability, and confirmation. The study found that 1) Implementation of group guidance services with sociodramaic techniques is carried out with the formation stage, transition stage, activity stage, and termination stage. Activities are carried out with due regard to guidance and sociodramaic procedures; 2) Student response is that students are very excited, comfortable, and more cooperating, more creative, and very enthusiastic; 3) Difficulties experienced by students that some students do not focus and sometimes disturb their friends; and 4) The teacher's constraints are limited time. The study concluded that the implementation of group guidance services with sociodrama techniques can increase students' learning motivation.Keywords: Guidance, Learning Motivation, Sociodrama
Antibacterial effect of Datura stramonium and Prosopis farcta extracts and effect on the cell viability
Authors: Shahroodian Soheila , Mirkalantari Shiva , Koupaei Maryam , Amirmozafari Nour
Published: May 2023

Researchers have focused on natural medicines to treat infectious
diseases due to antibiotic resistance. Due to the medicinal importance
of Datura stramonium and Prosopis farcta, the present study has
investigated their antimicrobial effects against some gram-positive and
negative bacteria by disc diffusion, micro broth dilution, and agar well
diffusion methods and also their possible toxicity using MTT assay
against HT29 cells. Additionally, the inhibitory effect of the extracts
on the formation of bacterial biofilms was investigated. The
hydroalcoholic extract of D. stramonium and P. fracta had antibacterial
effects on the bacteria in both micro broth dilution and agar well
diffusion methods. D.stramonium and P.fracta had the greatest effects on
S.aureus and P.aeruginosa. Their weakest effects were seen towards K.
pneumonia and A. baumannii. Anti-biofilm property was observed only for
D. stramonium extract (50 mg/ml concentration). MTT assay showed that
exposure of HT29 cells to concentrations of 25, 12.5, 6.25, and 3.1
mg/ml of D.stramonium and P.fracta extracts did not cause obvious
toxicity. P.farcta and D.stramonium inhibited the growth of bacteria as
well as biofilm formation in these strains, and they were not toxic to
human cells. Trials on patients using these extracts are recommended,
however
A Bivariate Spectral Linear Partition Method for Solving Nonlinear Evolution Equations
Authors: Khumalo Fezile Bangetile , Motsa Sandile , Magagula Vusi
Published: May 2023

This work develops a method for solving nonlinear evolution
equations. The method, termed a bivariate spectral linear partition
method, BSLPM, combines the Chebyshev spectral collocation method,
bivariate Lagrange interpolation, and a linear partition technique as an
underlying linearization method. It is developed for an n th
order nonlinear differential equation and then used to solve
three known evolution problems. The results are compared with known
exact solutions from literature. The method’s applicability,
reliability, and accuracy are confirmed by the congruence between the
numerical and exact solutions. Tables, error graphs, and convergence
graphs were generated using MATLAB (R2015a), to confirm the order of
accuracy of the method and verify its convergence. The performance of
the method is also observed against other methods performing well in
these types of differential equations and is found to be comparable in
terms of accuracy. The proposed method is also efficient as it uses
minimal computation time.
A Novel Approach to Managing Riverine Sediment Deposition
Authors: Gulduren Sevval , Ellingson Joe M. , Sharp Kendra V. , Grant Gordon , Selker John
Published: May 2023

Low-head dams can be built in ephemeral streambeds to trap sediments
which can store water or serve as sand reserves for other uses. For sand
dams to provide sustainable and dependable water supplies, or to provide
valuable sand for other purposes, these reservoirs should primarily fill
with coarse sand rather than fine sediments. The problem of sand dams
being negatively impacted by an excess of fine sediments is a widespread
issue. In Kenya, 40-60 percent of sand dams are reported to be affected
by this problem, which can limit their ability to recharge and provide
recoverable water. We describe a novel approach to preventing collection
of fine sediments by geomorphic management of reservoir sedimentation.
Specifically, we suggest building dams with “Eiffel Tower” shaped
outlets (broad at the base and narrowing with height) to remain open
until the reservoir is sediment filled. The opening is designed to
provide constant Rouse number of 2.5 for 0.125 mm grains so that
regardless of flow, only sand of size greater than 0.125 mm will
accumulate. Considering the limitations of 1-dimensional simulations in
capturing edge effects, a stage discharge relationship acquired through
HEC-RAS simulation is utilized to correct the opening. Numerical
modeling confirmed that these outlets maintain constant bed shear
stress, and thus promote the deposition of uniform coarse sediments
within the reservoir regardless of riverine flow rate. The findings of
the HEC-RAS simulation demonstrate that bottom-notch openings,
especially those of the “Eiffel Tower” shape, exhibit superior
performance with an MSE value of less than 1% when determining the
deviation between the desired Rouse number (2.5) and the calculated
Rouse number.
Spatiotemporal variations of groundwater level and gully impact in two peatland watersheds in the Source Region of the Yellow River
Authors: Li Zhiwei , Zhou Bingyu , Gao Peng , Guo Xiwei , Chen Bang , Tian Shimin
Published: May 2023

The spatiotemporal variability of groundwater level (GWL) is an
important property of peatland hydrology that directly affects
fluctuations of water storage. Nonetheless, current understanding of the
variations of GWL in different time scales still remains unclear. In
this study, two peatland watersheds (0.151 km for W1
and 0.844 km for W2) in the Zoige Basin in the
Source Region of the Yellow River (SRYR) were selected for monitoring
the temporal variability of GWL using self-recorded water loggers during
2017-2021. The main results demonstrate that: (1) GWL variations tended
to be controlled by gully drainage in sites adjacent to the gully and be
more synchronized with rainfall in sites distant from the gully. The GWL
near the gully that cuts through the peat layer was lower than that near
the gully without cutting through the peat layer, with a maximum
difference between the former and the latter of 58.3 cm, indicating the
effect of longitudinal attenuation of the GWL in W1. (2) Because
rainfall had a lag effect on the GWL, the length of lag gradually
decreased with increased rainfall intensity (i.e., the lag time of sites
far away from the gully was about 18 min shorter than that of sites
close to the gully in W1). (3) The peak values of the GWL occurred
simultaneously with the maximum and minimum rainfall in W2, and the peak
occurrence time was related to the ratio of precipitation to
evaporation. In the downstream sites, GWL fluctuated more intensively
than the upstream ones in W2. Moreover, the average GWL of the upstream
sites was 14.3 cm higher than that of the middle ones, indicating a
decreasing trend of water storage along the gully. (4) The GWL
discrepancy between wet and dry seasons was explicit, but the difference
was smaller in the upstream sites due to limited gully incision and
higher water storage within the peat layer. Additionally, rainy days
dominate the GWL change in wet and dry seasons, but the different
rainfall intensity resulted in a stable GWL in the dry season and an
oscillating GWL in the wet season in W2. This study uncovers the
spatio-temporal variation of groundwater level in two peatland
watersheds, which is of great significance for understanding runoff
variation, ecohydrological processes, and wetland shrinkage in the SRYR.
A New Metric based on the Weighted Class Complexity (WCC) metric and measure of complexity for Object-Oriented Systems
Authors: Dilmith P.G.T , Silva D. I. De , Peiris B.M.G , Pabasara W.A.C. , Dilshan P.A.D.S.D , Jayathilaka G.W.C.D
Published: May 2023

Class-level complexity is a significant component of software
complexity, and measuring software complexity is essential for software
development and maintenance. Although the Weighted Class Complexity
(WCC) metric has a long history of use, it has some drawbacks, including
the equal weighting of complexity components and the exclusion of some
complexity elements,. In this paper, we present a novel metric, the
Enhanced Weighted Class Complexity (EWCC) metric, which extends the WCC
metric by adding more complexity variables and weighting them according
to their relative relevance. Data access patterns, method call chains,
and control structure complexity are among the other variables. In order
to compare the EWCC metric’s output to the WCC metric’s output, we apply
it to a number of software systems. We assess the EWCC metric’s
performance in locating potential error and bug sources. The findings
indicate that, compared to the WCC metric, the EWCC metric offers a more
thorough and precise evaluation of class-level complexity. According to
the results, software developers and maintainers may find the EWCC
measure to be a useful tool for controlling software complexity.
Effective methylation triage of a screening population with HPV infection and/or abnormal cytology results in an Asian country
Authors: Zhou Guan-Nan , Gu Yuan-Yuan , Wang Qing , Ding Jing-Xin , Hua Keqin
Published: May 2023

Background: The S5-methylation test, as an alternative
classifier to cytology and HPV16/18 genotyping to triage cervical
squamous intraepithelial lesions, has not been widely validated in Asian
countries. Herein, we compared S5 methylation to HPV16/18 and cytology
to detect cervical high-grade squamous intraepithelial lesion (HSIL) in
a screening population who with either HPV infection or abnormal
cytology results or both of them, derived from a multi-central clinical
trial of 2246 Chinese participants. We matched all ≥HSIL+ cases (n=468)
with ≤LSIL controls (n=468) to analyze the effectiveness of methylation.
Methylation of S5 was quantified by pyrosequencing, blinded to cytology,
histological and initial HPV results. Results: The S5
methylation could distinguish women with ≥HSIL+ from women with ≤LSIL at
a high area under the curve (AUC) of 0.80 (95% CI 0.74-0.85). The
sensitivity of S5 methylation (at 2.85 cutoff) for ≥HSIL+ was 76.1%
(95% confidence interval [CI] 71.7-79.2) was higher than HPV16/18
sensitivity (64.9%, 95% CI 58.3-71.7, P = 0.039) or cytology
(48.9%, 95% CI 42.8-53.2, P < 0.001). At this cutoff,
the specificity of S5 for ≥HSIL+ was (79.9%, 95% CI 76.2-84.9), higher
than HPV16/18 (44.8%, 95% CI 40.1-49.4, P < 0.001)
and cytology (54.6%, 95%CI 50.7-57.9, P < 0.001). In
addition, S5 methylation could provide predictive information about
progression in specific population in follow-up period.
Conclusion: S5 methylation classifier with high sensitivity and
specificity exceeded HPV16/18 or cytology for detecting women with
≥HSIL+ in a screening Chinese population with HPV infection and/or
abnormal cytology results. Furthermore, S5 methylation is a potential
classifier for predicting progression.
Impact of hospitalization for vaso-occlusive crisis on health-related quality of life in children with sickle cell disease
Authors: Vuong Caroline , Moussa Ibtissame , Muilekom Maud van , Heijboer Harriët , Rettenbacher Eva , Haverman Lotte , Twisk Jos , Fijnvandraat Karin , Eckhardt Corien L.
Published: May 2023

Background: Sickle cell disease (SCD) is characterized by
vaso-occlusive crises (VOCs), that impair the health-related quality of
life (HRQoL). The aim of this study is to evaluate the impact of
hospitalization for VOCs on HRQoL in children with SCD over time.
Methods: In this longitudinal cohort study, children aged 8-18
years diagnosed with SCD at the Amsterdam UMC were included between 2012
and 2021. HRQoL was annually measured as part of standard care using the
Pediatric Quality of Life Inventory. The impact of hospitalization for
VOC on HRQoL was evaluated using linear mixed models 3, 6, 9 and 12
months after hospitalization. The effect of frequency of hospitalization
for VOC on HRQoL was evaluated over the last 12 months.
Results: In total , 94 children with SCD were included
with a median age of 11.8 years (IQR 9-14). Thirty-seven patients (39%)
had been hospitalized for a VOC. Hospitalization for VOC led to a
decrease of 3.2-4.8 points in total HRQoL compared to patients without
hospitalization, most pronounced 3 months after hospitalization.
Recurrent admission for VOC in the last 12 months was associated with a
decrease of 2.3 points in total HRQoL (p=0.04). The most affected
subscale was physical functioning. Conclusion: The adverse
effects of hospitalization for VOC in children with SCD persist up to 12
months after hospitalization. After hospitalization for VOC, extra
attention and support for its negative impact on HRQoL are recommended.
This study also underlines the importance of systematically measuring
HRQoL allowing clinicians to intervene accordingly.
Mpox stigma among men who have sex with men in the Netherlands: Underlying beliefs and comparisons across other commonly stigmatized infections
Authors: Zimmermann Hanne M.L. , Gültzow Thomas , Marcos Tamika , Wang Haoyi , Jonas Kai. J. , Stutterheim Sarah E.
Published: May 2023

People with mpox are likely to be stigmatized because of analogies to
other sexually transmitted infections. Stigma is driven by beliefs about
the perceived severity of the condition and perceived responsibility for
acquiring the condition, both in broader society and individual
responsibility. We explored these beliefs and compared them across mpox,
HIV, syphilis, gonorrhoea, and chlamydia in an online survey, conducted
in July, 2022, with 394 men-who-have-sex-with-men (MSM) in the
Netherlands. We compared mean scores between infections using repeated
measures ANOVA and conducted hierarchical regression analyses to
identify determinants of both mpox perceived responsibility endpoints.
Results showed that participants expected that mpox would be seen as a
‘gay disease’ and will be used to blame gay men. Compared to other
infections, mpox was considered less severe than HIV, but more severe
than syphilis, gonorrhoea, and chlamydia. Perceived responsibility was
comparable across infections, but, for each infection, participants
perceived attributed responsibility for infection to be higher in
society than individual responsibility. Both perceived responsibility
endpoints were highly correlated with each other and with other stigma
beliefs. These results provide insight on the underlying determinants of
mpox stigma, and demonstrate that mpox stigma is present in the
Netherlands.
Differences in bound water behaviour in Antarctic lichenized fungus from two different sites
Authors: Andrzejowska Aleksandra , Kubat Karol , Kowalski Tomasz , Strzałka Kazimierz , Casanova-Katny Angélica , Jakubiec Daniel , Olech Maria , Harańczyk Hubert
Published: May 2023

Adaptations of organisms to different environments may be important in
view of different stressors caused by climate change. Antarctic lichens
provide a good model for studying resistance to environmental extremes.
Our goal was to compare changes in water storage of Caloplaca
regalis from two different localities in Antarctica. King George Island
(KGI) and Deception Island (DI). DI is of particular interest owing to
the unique microclimate of the volcanic island. The molecular dynamics
of the residual water was monitored by H-NMR
relaxometry, spectroscopy, and sorption isotherm analysis. Hydration
kinetics for both samples distinguished three water fractions, (i) very
tightly bound, (ii) tightly bound, and (iii) loosely bound water.
However, hydration kinetics for C. regalis from KGI are faster
than those from DI. Only one, averaged, water fraction was fitted for
the H-NMR signal of mobile protons. Lichens from both
environments contain a solid water-soluble fraction. The dissolution
effect is detected with the saturation concentration varying around
c = 0,6(1) corresponding to sucrose, galactose
or xylose for the KGI sample and c = 0.3(1)
corresponding to mannitol or galactitol for the DI sample. This suggests
that C.regalis employs similar defensive strategies
against desiccation but uses different substances for them.
Feasibility and efficacy of an at-home, technology-supported mindfulness program in people with Multiple Sclerosis: a proof-of-principle study
Authors: Motolese Francesco , Stelitano Domenica , Lanzone Jacopo , Albergo Giuliano , Cruciani Alessandro , Masciulli Camilla , Musumeci Gabriella , Pilato Fabio , Rossi Mariagrazia , Ribolsi Michele , Lazzaro Vincenzo Di , Capone Fioravante
Published: May 2023

Background: Multiple Sclerosis (MS) is a chronic disease with a high
prevalence of neuropsychiatric symptoms. Mindfulness is a practice that
encourages individuals to cultivate a present-focused, acceptance-based
approach for managing neuropsychiatric symptoms. Its positive effect on
MS has been demonstrated, but learning such technique is expensive and
time-consuming. In this study, we investigated the feasibility and
efficacy of an 8-week, at-home, technology-supported mindfulness program
in a cohort of MS patients. Methods: The study included two visits, one
at baseline and another after the mindfulness program. We measured
adherence to the proposed mindfulness treatment and its effect on
different neuropsychological scales and in terms of quantitative EEG
parameters. All participants received a smart biofeedback device to be
used during the therapeutic program consisting of daily meditative
exercises. Results: Twenty-nine patients were recruited for the present
study. Among them, 27 (93%) completed the entire program and 17 (63%)
completed more than 80% of the scheduled sessions. We observed a
statistically significant reduction of the Ruminative Response Scale
score and a significant increase in the Digit Span Backward. Regarding
neurophysiological data, we found a significant reduction of the
whole-scalp beta and parieto-occipital theta power post intervention.
Conclusion: Our results show that an at-home, technology-supported
mindfulness program is feasible for people with MS. The efficacy in
terms of reappraisals of stress, cognitive and emotional coping
responses is also supported by our neurophysiological data. Further
studies are warranted to better explore the role of such approaches in
managing the psychological impact of MS diagnosis.
A spatial assessment of current and future foliar Hg uptake fluxes across European forests
Authors: Wohlgemuth Lena , Feinberg Aryeh , Buras Allan , Jiskra Martin
Published: May 2023

Atmospheric mercury (Hg) is deposited to land surfaces mainly through
vegetation uptake. Foliage stomatal gas exchange plays an important role
for net vegetation Hg uptake, because foliage assimilates Hg via the
stomata. Here, we use empirical relationships of foliar Hg uptake by
forest tree species to produce a spatially highly resolved (1 km2) map
of foliar Hg fluxes to European forests over one growing season. The
modelled forest foliar Hg uptake flux is 23 ± 12 Mg Hg season−1, which
agrees with previous estimates from literature. We spatially compare
forest Hg fluxes with modelled fluxes of the chemistry-transport model
GEOS-Chem and find a good overall agreement. For European pine forests,
stomatal Hg uptake was shown to be sensitive to prevailing conditions of
relatively high ambient water vapor pressure deficit (VPD). We tested a
stomatal uptake model for the total pine needle Hg uptake flux during
four previous growing seasons (1994, 2003, 2015/2017, 2018) and two
climate change scenarios (RCP 4.5 and RCP 8.5). The resulting modelled
total European pine needle Hg uptake fluxes are in a range of 8.0 - 9.3
Mg Hg season−1 (min - max). The lowest pine forest needle Hg uptake flux
to Europe (8 Mg Hg season−1) among all investigated growing seasons is
associated with unusually hot and dry ambient conditions in the European
summer 2018, highlighting the sensitivity of the investigated flux to
prolonged high VPD. We conclude, that stomatal modelling is particularly
useful to investigate changes in Hg deposition in the context of extreme
climate events.
Pointwise quasi hemi-slant submanifolds
Authors: Beyendi Selahattin , Akyol Mehmet , Stankovic Mica
Published: May 2023

The objective of this paper is to introduce a new class of submanifolds which
are called pointwise quasi hemi-slant submanifolds in almost Hermitian
manifolds which extends quasi hemi-slant, hemi-slant, semi-slant and slant
submanifolds in a very natural way. Several basic results in this respect
are proved in this paper. Moreover, we obtain some conditions of the
distributions which are involved in the definition of the new submanifolds.
We also get some results for totally geodesic and mixed totally geodesic
conditions for pointwise quasi hemi-slant submanifolds. Finally, we
illustrate some examples in order to guaranty the new kind of submanifolds.
Disappearance of chromium (3) trichloride injected intracutaneously
Authors: Pedersen NB , Naversten Y.
Published: May 2023

Abstract i not available.
Bioleaching - Eco-Friendly Approach for Management of Electronic Waste
Authors: A Gunjal
Published: May 2023

The different types of wastes viz., food, electronic, household, medical, etc. accumulate in large amount. The electronic waste is a serious problem which needs an urgent solution. The chemical process has disadvantages which is costly and causes soil and water pollution. Bioleaching using the microorganisms is a two-step process which can be used for the management of electronic wastes. The bioleaching is economical, eco-friendly and easy process in this. Bioleaching which is a biological process is very important. It is a sustainable approach. The metals leached during bioleaching can be used for making of precious jewellery and ornaments.
Potency of Ficus Exasparata Leaf Extract on Albino Mice Infected with Plasmodium Berghei Berghei
Authors: AA Dominic
Published: May 2023

This study was conducted to determine the effects of Ficus exasparata (sand paper plant) on albino mice experimentally infected with Plasmodium berghei berghei. The mice were grouped into four of five mice each. The mice in groups A,B, and C were inoculated with Plasmodium berghei berghei while those in the group D were not inoculated with the parasite to serve as the control group. Group A and B were treated with the ethanoic leaf extract of Ficus exasparata with 100mg/body weight/day and 200mg/body weight/day respectively for six days after inoculation with the parasite. The extract significantly suppressed the malaria parasite in the treated groups when compared with the control group. Phytochemical analysis of Ficus exasparata showed the presence of Tannins, Flavonoid, Saponins and Glycosides. The statistical tool used was Pearson Product Moment Correlation Coefficient (PPMC). The statistical analysis showed no significant difference between doses 100mg and 200mg, but there was a significant suppression of the parasite. It is therefore concluded, that Ficus exasparata extract is capable of treating infection with Plasmodium berghei berghei.
The Influence of Fashion Knowledge, Fashion Selection Factor, and Dress Etiquette on Dress Look
Authors: Apriliani Fatwa Dewi , Widihastuti  , Daryono Rihab Wit , Jaya Daniel Jesayanto , Rizbudiani Adilla Desy
Published: May 2023

Dharma Wanita members tend to pay less attention to ethics in dress and the use of uniform attributes according to regulations. This is caused by various professions, education, culture, and economy as well as a lack of knowledge about dressing. The purpose of this research is to analyze how the influence of fashion knowledge, clothing selection factors, and dress etiquette on dress appearance. The research was aimed at members of Dharma Wanita with a sample of 60 respondents taken by purposive sampling technique. A combination of factor analysis and regression analysis was used to analyze the data using second-order PLS-SEM analysis. Evaluation of the measurement model on convergent and discriminant validity as well as internal consistency reliability has met the requirements. The structural model evaluation shows a large influence contribution of 97.00%, and the research observation value is 60.10%. All hypotheses are accepted indicating that there is a positive and significant effect of all variables on dress appearance. Even though the category analysis is good, it is recommended for administrators provide rules for the use of work uniforms and good attributes to support work activities. Therefore, Dharma Wanita members can choose and repair clothes to make them more harmonious and beautiful to support their daily activities.
Beyond efficiency and renewables
Authors: Warren Christopher
Published: May 2023

Efficiency and renewables are not silver bullet solutions. They are essential to green hospitality, but they have their own costs and complexities that deserve our informed attention. Hospitality businesses must go further to meet their environmental targets. Rebounds and backfires often undo our savings gains. The complacency of ‘job done’ attitudes can dismantle all the gains of green initiatives. Savings don’t mean as much when people take them as license to waste. Carbon offsetting programmes do not absolve us of the responsibility to reduce emissions. Planting trees may feel good (and it is good!) but reducing carbon emissions demands a little more elbow grease than that. Carbon offsetting programmes should be but one piece in a broader green strategy.  Any plan worth its salt must be shaped around a site’s unique context. Beware the one-size-fits-all quick fixes. Every site is different and requires personalised sustainable solutions. Putting in the research reaps rich rewards.  Resource conserving is the crucial third piece in the puzzle. Behaviour should not just be included in sustainability strategies – it should be central. Staff and guests alike can transform green tourism; we just need to trust them.  This chapter will get you thinking differently about the foundations of sustainable hospitality, shining light on nuances we all need to understand and embrace. Only with that mindset can we hope to revolutionise the sector.
Conhecimento profissional do professor ao ensinar transformações geométricas
Authors: Nascimben Delmondi Munhóz Natalia , Pazuch Vinícius
Published: May 2023

Este artigo tem como objetivo identificar e compreender como os conhecimentos do professor impactam na sua prática em relação ao conteúdo de transformações geométricas. Para tanto, foi analisado qualitativamente, em junho de 2019, um episódio de aula em que tal conteúdo foi ministrado para uma turma do 8.º ano do Ensino Fundamental de uma Escola Municipal da cidade de São Paulo. Para tal, foi usada como principal referencial teórico e metodológico a ferramenta Knowledge Quartet (KQ). A partir dela foram levantados e categorizados 21 eventos críticos, sendo 5 deles discutidos nesse artigo. A análise deles evidenciou uma convergência entre as pesquisas teóricas e a prática do professor que ensina o conteúdo de transformações geométricas, e indicou lacunas no conhecimento docente e a utilização de exercícios fechados com desafios reduzidos para o ensino desse conteúdo. O KQ se mostrou uma ferramenta adequada para tal análise, com o intuito de destacar tais aspectos, de modo que tanto a formação inicial quanto a continuada de professores possam ser estruturadas de acordo com as demandas observadas na prática.