bluuebunny/crossref_metadata_2025 huggingface dataset:
Concrete cracks, wood burns: Competing narratives in the construction sector
Authors: Larasatie Pipiet , Young Kathy , Hansen Eric
Published: August 2024

Innate to the human condition are rules of thumb, or heuristics, important for our survival. It is widely understood that wood is combustible, and concrete is prone to cracking. These factors significantly drive our perceptions concerning the selection of materials used in construction. The present study aimed to better understand the competing narratives employed by supporters on both sides of this construction ‘material warfare’ and specifically investigate their advantage and disadvantage arguments. To meet our research objective, we looked at news media articles through Google search tool using keywords ‘wood vs concrete building construction’. The articles are published as early as 2006, and along the years, the competing conversations are more prominent with the ‘birth’ of mass timber in North America. The topic is also becoming an interest for specific audiences, such as architects, engineers, and insurance companies. Through inductive thematic analysis of 100 articles, we find that cost and sustainability are two dominant factors in the narratives. Each industry claims to be more cost effective and sustainable than the other, typically sniping at each other. This rhetoric, we argue, will not be beneficial for society and environmental justice. A sustainable built environment requires cross-sector collaboration between wood and concrete companies to handle difficulties that they cannot address successfully within their own sector.
When healthcare becomes sick: Recovering from ransomware
Authors: Mashinchi Mona Isazad , Acton Thomas , Datta Pratim Milton
Published: August 2024

This teaching case describes the ransomware attack on Ireland’s national health provider, the Health Service Executive (HSE), and how it recovered. The attack disrupted critical healthcare services across more than 50 hospitals and, in retrospect, highlighted significant cybersecurity vulnerabilities. The case provides an in-depth analysis of the events leading up to the attack, the immediate organizational and technical impacts, and the subsequent response and recovery efforts. It explores issues such as incident response, risk management, business continuity, and the broader implications for public health organizations. It provides insights into the complexities of managing cyber threats in a healthcare context and the importance of robust cybersecurity preparedness. This case is designed for both undergraduate and postgraduate students in courses related to information security, cybersecurity management, and information systems. Students will be encouraged to evaluate the HSE’s preparedness, response strategies, and long-term recovery plans, and to develop recommendations for enhancing cybersecurity resilience in similar organizations.
Harmony unveiled: Intricate the interplay of dietary factor, gut microbiota, and colorectal cancer—A narrative review
Authors: Endale Hiwot Tezera , Tesfaye Winta , Hassen Fethiya Seid , Asrat Wastina Bitewlign , Temesgen Elizabeth Yihune , Shibabaw Yadelew Yimer , Asefa Tseganesh
Published: August 2024

Diet plays a critical role in shaping the gut microbiome, which in turn regulates molecular activities in the colonic mucosa. The state and composition of the gut microbiome are key factors in the development of colorectal cancer. An altered gut microbiome, linked to weakened immune responses and the production of carcinogenic substances, is a significant contributor to colorectal cancer pathogenesis. Dietary changes that involve low-fiber and phytomolecule intake, coupled with higher consumption of red meat, can raise the risk of colorectal cancer. Salutary filaments, which reach the colon undigested, are metabolized by the gut microbiome, producing short-chain fatty acids. Short-chain fatty acids possess beneficial anti-inflammatory and antiproliferative properties that promote colon health. A well-balanced microbiome, supported by beneficial fibers and phytochemicals, can regulate the activation of proto-oncogenes and oncogenic pathways, thereby reducing cell proliferation. Recent research suggests that an overabundance of specific microbes, such as Fusobacterium nucleatum, may contribute to adverse changes in the colonic mucosa. Positive lifestyle adjustments have been demonstrated to effectively inhibit the growth of harmful opportunistic organisms. Synbiotics, which combine probiotics and prebiotics, can protect the intestinal mucosa by enhancing immune responses and decreasing the production of harmful metabolites, oxidative stress, and cell proliferation. This narrative review provides a concise understanding of evolving evidence regarding how diet influences the gut microbiome, leading to the restoration of the colonic epithelium. It underscores the importance of a healthy, plant-based diet and associated supplements in preventing colorectal cancer by enhancing gut microbiome health.
A systematic review on factors influencing Middle Eastern women’s utilization of healthcare services: The promise of mHealth
Authors: Khosravi Mohsen , Mojtabaeian Seyyed Morteza , Aghamaleki Sarvestani Mina
Published: August 2024

Objectives:

The 2030 Sustainable Development Agenda stresses a feminist approach for healthcare services. Cultural and religious influences impact utilization of healthcare services by Muslim women within the Middle East, posing unique challenges. This paper aimed to investigate the factors influencing Middle Eastern women’s utilization of healthcare services within the region.

Methods:

In the year 2024, a systematic review was conducted. PubMed, Scopus, ProQuest, and the Cochrane Database of Systematic Reviews were searched for this purpose. The quality of the included articles was assessed using the Accuracy, Coverage, Objectivity, Date, Significance (ACODS) checklist. Subsequently, the Joffe method of thematic analysis was employed to analyze the data obtained from the review.

Results:

A final selection comprising 59 studies was made for inclusion in the research. The studies demonstrated a high level of quality, and the risk of bias within them was deemed acceptable. The thematic analysis revealed seven principal themes, which encompassed Demographic Factors, Level of Education and Awareness, Sources of Information, Risk Factors, Personal Factors, Level of Service Access and Quality, and Organizational Factors.

Conclusions:

This study highlighted key factors influencing women’s utilization of healthcare in the Middle East and potentially the healthcare systems with a large number of Middle Eastern female immigrants around the globe: educational factors such as awareness campaigns and patient education, and personal barriers like fear and cultural norms. Moreover, Telehealth, particularly mHealth, was suggested to enhance women’s participation and utilization of healthcare services. Further research is needed to explore this assertion with greater precision.
Acute epigastric pain unveiling biventricular myocardial infarction: A case report
Authors: Diallo Thierno Hamidou , Djafarou Boubacar Raynatou , Nana Yeboah Frederick , Ekhya Amoumoune Fatima , Mohamed Aden Fatouma , Bendagha Nesma , Fellat Rokya
Published: August 2024

Acute coronary syndromes are a clinical entity frequently encountered in practice and are responsible for significant morbidity and mortality, despite therapeutic advances. The initiation of early reperfusion therapy reduces mortality and morbidity and improves patients’ prognosis, but this depends on how quickly patients receive their treatment. Although it is often easy to diagnose in the presence of typical symptoms, certain patients, such as diabetics, sometimes have atypical symptoms, resulting in a delay in management. In nearly 50% of cases, inferior wall ischaemia is accompanied by right ventricular myocardial infarction; the clinical outcomes range from no hemodynamic compromise to severe hypotension and cardiogenic shock. In this article, we present the case of a 54-year-old male patient with active smoking and poorly controlled type 2 diabetes as cardiovascular risk factors who initially consulted at the first hour for epigastric pain, for which he received symptomatic treatment. As the symptoms persisted, he was admitted to our department at the eighth hour, where he was diagnosed with a biventricular infarction.
‘Living-alone’ wanghong: Women’s singleness as a wanghong genre and the configuration of Chinese postfeminist wanghong culture
Authors: Guo Jia
Published: August 2024

In this article, I explore how women’s singleness is represented by ‘living-alone’ wanghong on the Chinese social media platform Xiaohongshu (小红书) and discuss the configuration of Chinese postfeminist wanghong culture. The term ‘“living-alone” wanghong’ refers to a group of Chinese vloggers – mostly women – who showcase their daily lives in domestic spaces while living by themselves. ‘Living-alone’ wanghong narrate their singleness as an autonomous choice that leads to a happy, high-quality, and bourgeois life. This narrative is distinct from the stigmatised ‘ shengnü’ (剩女, leftover women) discourse in contemporary urban China. By conducting thematic analysis of 50 sampled ‘living-alone’ vlogs featuring female wanghong, I examine three recurring themes: economic independence; self-care/self-discipline; and enjoyable loneliness. The analysis contextualises these three tropes in the postfeminist wanghong culture on Chinese social media. I argue that while ‘living-alone’ wanghong productively challenge stigmas around single women in the context of urban China, they ultimately transform women’s singleness into a neoliberal and postfeminist object in feminised consumer culture. Within their narratives, the structural struggles that single women face become issues that can and should be resolved by individual women. This transformation overshadows the underlying logic of consumption/commercialisation within Chinese postfeminist wanghong culture. This article further discusses the importance of the intersectional gender dimension in wanghong studies, as evidenced by the case study of ‘living-alone’ wanghong.
Load Changes on a Short-Segment Posterior Instrumentation After Transosseous Disruption of L3 Vertebra – A Biomechanical Human Cadaveric Study
Authors: Heumann Maximilian , Jacob Alina , Gueorguiev Boyko , Richards R. Geoff , Benneker Lorin M.
Published: August 2024

Study Design

Biomechanical Cadaveric Study.

Objectives

Following the successful use of a novel implantable sensor (Monitor) in evaluating the progression of fracture healing in long bones and posterolateral fusion of the spine based on implant load monitoring, the aim of this study was to investigate its potential to assess healing of transosseous fractures of a lumbar vertebra stabilized with a pedicle-screw-rod construct.

Methods

Six human cadaveric spines were instrumented with pedicle screws and rods spanning L3 vertebra. The spine was loaded in Flexion-Extension (FE), Lateral-Bending (LB) and Axial-Rotation (AR) with an intact L3 vertebra and after its transosseous disruption, creating an AO B1 type fracture. The implant load was measured on the one rod using the Monitor and on the contralateral rod by strain gauges to validate the Monitor’s measurements. In parallel, the range of motion (ROM) was assessed.

Results

ROM increased significantly in all directions in the fractured model ( P ≤ 0.049). The Monitor measured a significant increase in implant load in FE ( P = 0.002) and LB ( P = 0.045), however, not in AR. The strain gauge – aligned with the rod axis and glued onto its posterior side – detected an increased implant load not only in FE ( P = 0.001) and LB ( P = 0.016) but also in AR ( P = 0.047).

Conclusion

After a complete transosseous disruption of L3 vertebra, the implant load on the rods was considerably higher vs the state with an intact vertebral body. Innovative implantable sensors could monitor those changes, allowing assessment of the healing progression based on quantifiable data.
Atypical Site of Presentation of a Rare Type of SMARCA4-Positive Cutaneous Squamous Cell Carcinoma of the Skin: Case Report and Review of the Literature
Authors: Yadav Ruchi , Din Shaun , Moussaris Harry , Yadav Vivek , Raman Shakthi , Gandhi Anjula , Avezbakiyev Boris , Wang J. C.
Published: August 2024

Cutaneous squamous cell carcinoma (cSCC) comprises 20% of cases of nonmelanoma skin cancers in the United States. In total, 3% to 5% of squamous cell carcinoma (SCC) are metastatic at the time of presentation, associated with significant mortality due to a lack of standardized treatment options. In total, 95% of these tumors are amenable to the initial standard of treatment, which is surgical resection. However, a small percentage of them require systemic therapy as they are either locally advanced to regional lymph nodes or have distant metastasis. The common sites of presentation of cSCC are the scalp and the face with predictable spread to the intra-parotid, upper jugular, and perifacial lymph nodes. In our case report, however, our patient had a large lump lesion on the upper back, an unusual site of presentation of cSCC, with locally advanced metastasis to the left axillary lymph nodes. Subsequently, the tumor marker study revealed a positive SMARCA4 variant (the essential ATPase subunit of the Switch (SWI)/Sucrose Nonfermenting (SNF) chromatin-remodeling complex) that is even rarer in the context of cSCC. Furthermore, abnormalities in SWI/SNF chromatin-remodeling complex subunits have shown promising results as a target therapy for immune checkpoint inhibitor (ICI) therapy. We present an atypical presentation site of locally advanced rare variant SMARCA4-positive cSCC in a patient who received treatment with chemoradiation and systemic therapy with ICI after primary surgical resection. To date, only 2 cases of SMARCA4-positive cSCC were found in the literature with no details of the treatment received. Our case is unique in its atypical site of presentation as well as showing partial response to radiotherapy (RT) and systemic therapy with ICI.
Enteric Duplication Cyst Associated With Meckel’s Diverticulum: A Rare Cause of Acute Abdomen
Authors: Ponniah Kugendran , Kinsey-Trotman Stephen , Agarwal Naveen , Lachlan Dandie , Kozman Matthew
Published: August 2024

We report a case of a 26-year-old type 1 diabetic woman presenting with acute lower abdominal pain, bloating, and vomiting. Initial examination revealed right lower quadrant tenderness and a suprapubic mass. Computed tomography (CT) imaging identified a 12-cm cystic structure suggestive of a dilated bowel loop with an adjacent inflamed 7-cm small bowel segment. Surgical exploration uncovered a Merkel’s diverticulum–associated duplication cyst originating from the Meckel’s diverticulum. Subsequent complications included an anastomotic leak, requiring relook laparotomy and the formation of a double-barrel stoma. The patient recovered and was discharged on day 13. This case highlights the diagnostic challenge of Meckel’s diverticulum-associated duplication cysts, emphasizing the need for vigilance in managing complex abdominal presentations.
Non-recurrent Laryngeal Nerve During Intraoperative Neuromonitoring Thyroidectomy: A Case Report and Literature Review
Authors: Inversini Davide , Gianazza Simone , Annoni Matteo , Leotta Andrea , Confalonieri Dorotea , Ferri Enrico , Palillo Andrea , Vigezzi Andrea , Garbarino Sabrina , Ietto Giuseppe , Carcano Giulio
Published: August 2024

Complete and precise knowledge of the neck anatomy and its eventual anomalies is crucial while performing a safe thyroid and parathyroid surgery. Embryo-genetic malformations of the IV branchial arch can lead to an uncommon anatomical alteration known as non-recurrent inferior laryngeal nerve. Its prevalence varies between 0.7% for the dextral branch and 0.04% for the sinistral. In these cases, the inferior laryngeal nerve branches originate directly from the cervical vagus nerve, entering the larynx without hooking, on the right side around the subclavian artery or on the left around the aortic arch. The presence of a non-recurrent laryngeal nerve is challenging, due to the increased risks of iatrogenic damage to the nerve, which results in hoarseness, dysphagia, glottal obstruction, vocal cords palsy, and serious airway impairment. We present the case of a 58-year-old woman. The patient was admitted to our department for a nodule classified as Bethesda IV in the right thyroid lobe. Through the use of intraoperative neuromonitoring (IONM), surgeons detected intraoperatively a non-recurrent laryngeal nerve. A subsequent computed tomography scan confirmed an anomalous right subclavian artery branching from the left aortic arch, the Lusoria Artery. Anatomical variants represent pitfalls in this case and an accurate knowledge of the neck region is imperative while performing thyroid surgery. Devices such as IONM are useful for detecting abnormalities that may lead to iatrogenic damages.
User Satisfaction with Primary Health Care Rehabilitation Services in a South African Metropolitan District
Authors: Maseko Lebogang , Myezwa Hellen , Adams Fasloen
Published: August 2024

Rehabilitation services are critical to improve health outcomes, particularly at community level within primary healthcare settings. As groups with an interest in the health system, rehabilitation service users’ and caregivers’ involvement in various aspects of health system strengthening is important for healthcare planning and evaluation. This study aimed to explore rehabilitation service users’ perceptions of the rehabilitation services and their effect on their functioning in the Johannesburg Metropolitan District. A qualitative study was conducted using purposive sampling of participants attending rehabilitation at nine provincially funded clinics. Semi-structured interviews were conducted, and data were analysed using reflexive thematic analysis. The findings revealed the theme of happy with rehabilitation services and five associated categories, namely (1) service provider actions, (2) service organisation, (3) service user actions, (4) service access, and (5) service outcomes. The participants expressed overall satisfaction with their experiences of rehabilitation services, highlighting the importance of effective communication, patient-centred care, strong therapeutic relationships, and active patient engagement to achieve positive outcomes. This study provides the evidence for maintaining and extending rehabilitation at the PHC level in support of the health policy changes proposed for South Africa.
Writing Justly: Crafting Intentional Emails to Enhance Perceptions of Justice
Authors: Mercado Brittany K.
Published: August 2024

Employee perceptions of organizational justice influence every aspect of the workplace, from morale to productivity. Learning to recognize forms of injustice and proactively address them is a key developmental objective for management students. In this experiential exercise, students simulate the role of leaders and communicate a difficult decision via an email that optimizes perceptions of organizational justice. We developed a variety of decision prompts, including a promotion denial, a student leadership opportunity denial, and a suboptimal merit raise, to enhance suitability for different courses. Through active learning, students apply knowledge of organizational justice and practice delivering feedback that explicitly addresses fairness. An extensive debriefing guide, variations for asynchronous classes, and sample instructor slides are provided. This exercise is appropriate for late-stage undergraduate or graduate students of general management, human resource management, and organizational behavior.
Development of a Canadian Medical Assistance in Dying Curriculum for Healthcare Providers
Authors: Shapiro Gilla K. , Hunt Kate , Braund Heather , Dalgarno Nancy , Panjwani Aliza A. , Stevens Sarah , Mulder Jeanne , Sheth Madurika S. , Stere Alison , Green Stefanie , Gubitz Gord , Li Madeline
Published: August 2024

Objectives

Medical Assistance in Dying (MAiD) was legalized in Canada in 2016, necessitating greater education and training in MAiD for physicians and nurse practitioners. To meet this need, the Canadian MAiD Curriculum (CMC) was developed to offer a nationally accredited, comprehensive, bilingual, hybrid (synchronous and asynchronous) educational program to support and enhance the practice of MAiD in Canada.

Methods

This work describes the process of developing the CMC, including its guiding principles and framework. The CMC was guided by constructivism and adult learning theory, preliminary literature review, 5 key principles based on a needs assessment survey, as well as consultation with diverse partners.

Results

Seven modules were developed: (1) foundations of MAiD in Canada, (2) clinical conversations that includes MAiD, (3) how to do an MAiD assessment, (4) capacity and vulnerability, (5) providing MAiD, (6) navigating complex cases with confidence, and (7) MAiD and mental disorders. An eighth topic on clinician resilience and reflection was woven into each of the 7 modules.

Conclusion

This curriculum ensures that consistent information is available to healthcare providers concerning the practice of MAiD in Canada. To ensure sustainability, the CMC will continue to be updated alongside the evolution of MAiD policy and services in Canada.
Comparative effectiveness and safety of direct oral anticoagulants and warfarin in atrial fibrillation patients with dementia
Authors: Fang Chen-Wen , Hsieh Cheng-Yang , Yang Hsin-Yi , Tsai Ching-Fang , Sung Sheng-Feng
Published: August 2024

Introduction:

Developing an effective stroke prevention strategy is crucial for elderly atrial fibrillation (AF) patients with dementia. This is due to the limited and inconsistent evidence available on this topic. In this nationwide, population-based cohort study, we aim to compare the effectiveness and safety of direct oral anticoagulants (DOACs) and warfarin in AF patients with dementia.

Patients and methods:

We identified AF patients with dementia, aged 50 years or older, from Taiwan’s National Health Insurance Research Database between 2010 and 2019. The primary outcome was a composite of hospitalizations due to ischemic stroke, acute myocardial infarction, intracranial hemorrhage, or major bleeding, as well as all-cause mortality. We used 1:1 propensity score matching and Cox proportional hazard models to adjust for confounding factors when comparing outcomes between warfarin and DOAC (apixaban, dabigatran, edoxaban, or rivaroxaban) users or warfarin and each individual DOAC.

Results:

There were 2952 patients in the DOAC-warfarin matched cohort. The apixaban-, dabigatran-, edoxaban-, and rivaroxaban-warfarin matched cohorts had 2346, 2554, 1684, and 2938 patients, respectively. The DOAC group, when compared to warfarin, was associated with a lower risk of both the composite outcome (hazard ratio (HR), 0.81; 95% confidence interval (CI) 0.69–0.95) and ischemic stroke (HR 0.65; 95% CI 0.48–0.87). Apixaban (HR 0.79; 95% CI 0.66–0.94), dabigatran (HR 0.64; 95% CI 0.53–0.77), and rivaroxaban (HR 0.82; 95% CI 0.70–0.97) were also associated with a lower risk of the composite outcome.

Discussion and conclusion:

Compared to warfarin, DOACs, whether as a group or apixaban, dabigatran, or rivaroxaban individually, were associated with a reduced risk of the composite outcome in elderly patients with concurrent AF and dementia.
Haemophilus influenzae Endophthalmitis Associated With Intravitreal Pegcetacoplan Injection
Authors: Jiao George , Zhu Daniel , Shakin Jeffrey L. , Li Albert S.
Published: August 2024

Purpose: To describe a case of endophthalmitis caused by Haemophilus influenzae, an encapsulated bacterium, after intravitreal (IVT) injection of pegcetacoplan. Methods: A single retrospective case was evaluated. Results: An 88-year-old woman with a history of diabetes mellitus, on dialysis for chronic kidney disease, hypertension, hypothyroidism, diffuse large B-cell lymphoma, and geographic atrophy in both eyes received an IVT injection of pegcetacoplan in both eyes. She subsequently developed endophthalmitis in the right eye caused by H influenzae. Further bloodwork showed Proteus mirabilis bacteremia. Conclusions: Pegcetacoplan, a complement inhibitor, may be associated with intraocular infections with encapsulated organisms, especially in immunocompromised patients.
Association of vitamin A with gestational diabetes and thyroid disorders in pregnancy and their influence on maternal, fetal, and neonatal outcomes
Authors: Qadeer Abdul , Ishaq Muhammad Umer , Safi Adnan , Akbar Anum , Asif Sana , Komel Aqsa , Kunwar Digbijay , Bokhari Syed Mujtaba Azhar
Published: August 2024

Gestational diabetes mellitus (GDM) and thyroid disorders during pregnancy pose significant health concerns, impacting a substantial number of mothers globally. Globally, about 14% of pregnant women develop GDM, while thyroid disorders impact approximately 2%–3%. Both conditions contribute to adverse outcomes, including gestational hypertension, excessive fetal growth, and heightened perinatal morbidity. The central focus of this literature review is to examine the relationship between vitamin A, a crucial fat-soluble micronutrient in fetal development, and the occurrence of GDM and thyroid disorders during pregnancy. The primary research question investigates the association between vitamin A, GDM, and thyroid disorders, analyzing their combined impact on maternal, fetal, and neonatal outcomes. The review underscores the potential of vitamin A to modulate the risk and outcomes of GDM and thyroid disorders during gestation, emphasizing its role in GDM development and resolution and its influence on thyroid function in pregnancy.
Qualitative Analysis of the Lived Experience of Individuals After Undergoing Osseointegration for Transfemoral Amputation
Authors: Furtado Michael , Carneglia Joseph , Fletcher Rebecca , Spitaletto Lindsay , Swift Summer
Published: August 2024

Objective:

The purpose of this study was to qualitatively assess the first-hand lived experiences of patients with amputation who had transitioned from a traditional socket (TS) to Osseointegration (OI) to impact their overall quality of life (QOL) and function.

Methods:

This was a qualitative phenomenological study. Participants who had a unilateral transfemoral amputation and fit the study’s inclusion criteria were interviewed in a semi-structured format regarding their quality of life and function before and after transitioning from a traditional socket (TS) to Osseointegration (OI). Responses were then analyzed through line-by-line coding to determine themes that were relevant to QOL outcomes for this study.

Results:

Eleven participants were interviewed in this study. The qualitative analysis demonstrated an emergence of 6 main themes consisting of “Improved Quality of Life,” “Supportive Community,” “Previous Ill-fitting Socket,” “Greater Function,” “Improved Osseo-perception,” and “Promotion of Community Accessibility”. Strengths included the use of an OI-specific quality of life assessment with adapted questions from validated outcome measures, international participants, and use of thematic analysis for data analysis. Weaknesses included sample size, niche participant population, and OI as a revision procedure only. More research is still necessary to explore/determine the benefits and detriments of Osseointegration as an alternative to traditional sockets for prosthetic devices.

Conclusion:

Individuals who have undergone Osseointegration procedure discuss being more satisfied with their prosthesis and quality of life when compared to their previous experience of a traditional socket.

Impact Statement:

This is a first of its kind study reporting on the lived experiences of those who have undergone OI. The field of amputation rehabilitation is expanding rapidly and knowing how this procedure impacts quality of life is important for healthcare professionals to understand as new frontiers are explored in this field.
Organizational Entrainment of Project Launch in the Research Context of Chinese Real Estate Firms
Authors: Cheng Sheng-Qiang , Jing Run-Tian , Sun Xuan
Published: August 2024

Despite wide recognition of organizational entrainment (i.e., activities pace adjustment to catch emerging opportunity) in case studies, there is a lack of large-sample empirical evidence illustrating entrainment in project management. We examine outcome-based and process-based entrainment using survival analysis with 90,755 observations of 149 Chinese real estate firms’ residential development projects. The results suggest external environmental favorableness—as a zeitgeber—both directly accelerates the project launch pace and strengthens the deceleration effects of structural inertia and acceleration effects of resource munificence on the project launch pace. Our study contributes to organizational entrainment, flexibility-focused project management, and project launch literature.
The role of social motivation in sharing and fairness: insights from Williams syndrome
Authors: Foti Francesca , Costanzo Floriana , Fabrizio Carlo , Termine Andrea , Menghini Deny , Iaquinta Tiziana , Vicari Stefano , Petrosini Laura , Blake Peter R.
Published: August 2024

Background

Sharing and fairness are important prosocial behaviors that help us navigate the social world. However, little is known about how and whether individuals with Williams Syndrome (WS) engage in these behaviors. The unique phenotype of individuals with WS, consisting of high social motivation and limited social cognition, can also offer insight into the role of social motivation in sharing and fairness when compared to typically developing (TD) individuals. The current study used established experimental paradigms to examine sharing and fairness in individuals with WS and TD individuals.

Methods

We compared a sample of patients with WS to TD children (6-year-olds) matched by mental age (MA) on two experimental tasks: the Dictator Game (DG, Experiment 1, N = 17 WS, 20 TD) with adults modeling giving behaviors used to test sharing and the Inequity Game (IG, Experiment 2, N = 14 WS, 17 TD) used to test fairness.

Results

Results showed that the WS group behaved similarly to the TD group for baseline giving in the DG and in the IG, rejecting disadvantageous offers but accepting advantageous ones. However, after viewing an adult model giving behavior, the WS group gave more than their baseline, with many individuals giving more than half, while the TD group gave less. Combined these results suggest that social motivation is sufficient for sharing and, in particular, generous sharing, as well as the self-focused form of fairness. Further, individuals with WS appear capable of both learning to be more generous and preventing disadvantageous outcomes, a more complex profile than previously known.

Conclusions

In conclusion, the present study provides a snapshot into sharing and fairness-related behaviors in WS, contributing to our understanding of the intriguing social-behavioral phenotype associated with this developmental disorder.
Experiences managing behavioral symptoms among Latino caregivers of Latino older adults with dementia and memory problems: a qualitative study
Authors: Keller Michelle S. , Guevara Nathalie , Guerrero Jose-Armando , Mays Allison M. , McCleskey Sara G. , Reyes Carmen E. , Sarkisian Catherine A.
Published: August 2024

Background

Latinos are more likely than non-Latino Whites to develop dementia and be prescribed antipsychotics for dementia-related behavioral symptoms. Antipsychotics have significant risks yet are often overprescribed. Our understanding of how Latino caregivers of Latino older adults living with dementia perceive and address behavioral issues is limited, impeding our ability to address the root causes of antipsychotic overprescribing.

Methods

We interviewed Latino older adults’ caregivers and community-based organization workers serving older adults with cognitive impairment (key informants), focusing on the management of behavioral symptoms and experiences with health services.

Results

We interviewed 8 caregivers and 2 key informants. Caregivers were the spouses, children, or grandchildren of the older adult living with cognitive impairment; their ages ranged from 30 to 95. We identified three categories of how caregivers learned about, managed, and coped with behavioral symptoms: caregivers often faced shortcomings with dementia care in the medical system, receiving limited guidance and support; caregivers found community organizations and senior day centers to be lifelines, as they received relevant, timely advice and support, caregivers often devised their own creative strategies to manage behavioral symptoms.

Conclusion

In-depth interviews suggest that the healthcare system is failing to provide support for behavioral symptoms from dementia; caregivers of Latino older adults rely on community organizations instead.
Hepatitis B prevalence and risk factors among adults living with HIV in South Africa: a clinic-based cohort study
Authors: Shivakumar Megana , Moe Caitlin A. , Bardon Ashley , Krows Meighan , Govere Sabina , Moosa Mahomed Yunus S. , Celum Connie , Drain Paul K.
Published: August 2024

Background

People living with HIV (PLHIV) may have concurrent Hepatitis B Virus (HBV) infection, and certain antiretroviral therapies are recommended for HBV-HIV co-infected individuals. Routine screening for Hepatitis B virus may influence management of antiretroviral therapy for PLHIV, but risk factors for co-infection have not been well defined. The objective of this study was to identify risk factors for HBV infection among PLHIV in South Africa.

Methods

We conducted a cross-sectional analysis of a prospective, clinic-based cohort study of adults seeking HIV testing from 2013–2017 in Umlazi township, South Africa. Patients newly diagnosed with HIV were enrolled and subsequently tested for Hepatitis B surface antigen positive (HBsAg +). We used a Poisson linear regression model to assess which factors, pertaining to sociodemographic status, medical history, clinical symptoms, mental health were associated with HBV.

Results

Among 3,105 PLHIV participants in South Africa, 6% were positive for HBV. Males had a higher HBV prevalence (10.4%) than females (5.2%). Within the HBV-positive group, the mean age was 33.2 years, with 38.3% females and 43.9% having completed high school or higher. About 39.9% reported alcohol use, 24.7% had a smoking history, and 8.3% reported substance use in the past year. Older participants born before 1995, when routine infant HBV vaccination was introduced, were more likely to have HBV. In multivariable analyses, smoking history increased HBV risk in females (aPR = 2.58; 95% CI 1.47–2.52), while alcohol use decreased HBV risk in males (aPR = 0.36; 95% CI 0.19–0.70).

Conclusions

In a South African cohort, roughly one in 16 PLHIV had HBV co-infection, and this rate was higher in males. The most prominent risk factors for HBV infection in PLHIV were alcohol use, higher income, and smoking history, which may help inform targeted treatment and prevention strategies. Creating HBV-specific screening and prevention strategies for PLHIV may be useful for reducing HBV infections.
Glomerulonephritis during Mycobacterium tuberculosis infection: scoping review
Authors: Forster Adam , Sabur Natasha , Iqbal Ali , Vaughan Stephen , Thomson Benjamin
Published: August 2024

Introduction

People with Tuberculosis (TB) infection may present with glomerulonephritis (GN). The range of presentations, renal pathologies, and clinical outcomes are uncertain. Whether clinical features that establish if GN etiology is medication or TB related, and possible benefits of immunosuppression remain uncertain.

Methods

A scoping review was completed, searching MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science and Conference Abstracts from Inception to December, 2023. The study population included patients with TB infection who developed GN and underwent renal biopsy. All data regarding presentation, patient characteristics, renal pathology, management of TB and GN, and outcomes were summarized.

Results

There were 62 studies identified, with 130 patients. These cases included a spectrum of presentations including acute kidney injury, nephrotic syndrome and hypertension, and a range of 10 different renal pathology diagnoses. Cases that included immunosuppression and outcomes ranged from complete remission to long-term dialysis dependence. The presence of granulomas (4/4, 100%), anti-glomerular basement membrane disease (3/3, 100%), amyloidosis (75/76, 98.7%), and focal segmental glomerulosclerosis (2/2, 100%) were specific for GN being TB-infection related. On the other hand, minimal change disease was specific for anti-TB therapy related (7/7, 100%). While patients with more aggressive forms of GN commonly were prescribed immunosuppression, this study was unable to confirm efficacy. Only rifampin or isoniazid were implicated in drug-associated GN.

Discussion

This study provides a clear rationale for renal biopsy in patients with TB and GN, and outlines predictors for the GN etiology. Thus, this study establishes key criteria to optimize diagnosis and management of patients with TB and GN.
Optimizing labor duration with pilates: evidence from a systematic review and meta-analysis of randomized controlled trials
Authors: Haseli Arezoo , Eghdampour Farideh , Zarei Hosna , Karimian Zahra , Rasoal Dara
Published: August 2024

Background

Pilates has captured interest due to its possible advantages during pregnancy and childbirth. Although research indicates that Pilates may reduce labor duration, alleviate pain, and improve satisfaction with the childbirth experience, consensus on these outcomes remains elusive, underscoring the necessity for additional studies.

Aim

This systematic review and meta-analysis aimed to assess the impact of Pilates exercises on labor duration among pregnant women.

Methods

The online database was searched to yield the literature using the terms of ‘Pilates’, ‘childbirth’, and ‘labor duration’, and similar terms including PubMed, Clinical Key, Scopus, Web of Science, Embase, and Cochrane Database of Systematic Reviews up to June 25, 2023. Studies were considered eligible if they were randomized or clinical controlled trials (RCTs/CCTs) published in English, focusing on healthy pregnant women without exercise contraindications. The studies needed to include interventions involving Pilates or exercise movement techniques, a comparison group with no exercise, and outcomes related to labor duration, the period of the active phase, and the second stage of delivery.

Results

Eleven studies, totalling 1239 participants, were included in the analysis. These studies provided high-quality evidence from exercise only RCTs/CCTs. The findings indicated a significant reduction in the active phase of labor (8 RCTs, n = 1195; Mean Difference [MD] = -56.35, 95% Confidence Interval [CI] [-89.46 to -23.25]) and overall labor duration (8 RCTs, n = 898; MD = -93.93, 95% CI [-138.34 to -49.51]) in pregnant women who engaged in Pilates exercises compared to those who did not but doesn’t affect on the duration of the second stage of labor (7 RCTs, n = 1135; MD = -0.11, 95% CI [-7.21 to 6.99]).

Conclusions

While this review primarily addresses the effects of Pilates on healthy and low-risk pregnant women, the findings suggest a potential role for Pilates in shortening labor duration. Therefore, engaging in Pilates or similar physical activities is recommended for pregnant women to potentially facilitate a more efficient labor process.
What are the experiences of colorectal cancer patients with biomarker testing in Canada?: a mixed methods study
Authors: Tongol Elijah , Kang Preet , Cheng Vicki , Gastonguay Louise , Beaudry Felix E. G. , Servidio-Italiano Filomena , De Vera Mary A.
Published: August 2024

Objective

Molecular or biomarker testing to guide targeted treatments for colorectal cancer (CRC) has advanced care, specifically by improving treatment specificity. Our objective was to explore patients’ experiences and perspectives with biomarker testing in Canada.

Methods

We conducted a mixed-methods study among adults (≥ 18 years) who have been diagnosed with CRC and able to communicate in English. Quantitative data was gathered using an online survey, with questions on awareness of and experiences with biomarker testing. Qualitative data was gathered using semi-structured interviews with a sample of survey respondents to provide context to survey findings.

Results

Among 55 survey respondents, 76% have heard of biomarker testing and of these, 67% have had biomarker testing done. Among the 33% of respondents that have not had biomarker testing done, reasons were: not offered/referred, fear/anxiety over results, and cost. Respondents who had biomarker testing largely found biomarker testing useful (89%), though, only half indicated that they were able to understand the information on their biomarker testing report. Qualitative analysis of interview transcripts identified four themes: 1) perceived benefits of biomarker testing, 2) knowledge of biomarker testing, 3) experiences with accessing and receiving biomarker testing, and 4) recommendations for addressing challenges with biomarker testing.

Conclusion

Altogether, our study provides insight into CRC patients’ perspectives and experiences with biomarker testing. Ongoing efforts by patient organizations, providers, and policymakers to improve awareness and access to biomarker testing must be informed by the patient perspective.
Impaired glucose metabolism and the risk of vascular events and mortality after ischemic stroke: A systematic review and meta-analysis
Authors: Kaynak Nurcennet , Kennel Valentin , Rackoll Torsten , Schulze Daniel , Endres Matthias , Nave Alexander H.
Published: August 2024

Background

Diabetes mellitus (DM), prediabetes, and insulin resistance are highly prevalent in patients with ischemic stroke (IS). DM is associated with higher risk for poor outcomes after IS.

Objective

Investigate the risk of recurrent vascular events and mortality associated with impaired glucose metabolism compared to normoglycemia in patients with IS and transient ischemic attack (TIA).

Methods

Systematic literature search was performed in PubMed, Embase, Cochrane Library on 21st March 2024 and via citation searching. Studies that comprised IS or TIA patients and exposures of impaired glucose metabolism were eligible. Study Quality Assessment Tool was used for risk of bias assessment. Covariate adjusted outcomes were pooled using random-effects meta-analysis.

Main outcomes

Recurrent stroke, cardiac events, cardiovascular and all-cause mortality and composite of vascular outcomes.

Results

Of 10,974 identified studies 159 were eligible. 67% had low risk of bias. DM was associated with an increased risk for composite events (pooled HR (pHR) including 445,808 patients: 1.58, 95% CI 1.34–1.85, I2 = 88%), recurrent stroke (pHR including 1.161.527 patients: 1.42 (1.29–1.56, I2 = 92%), cardiac events (pHR including 443,863 patients: 1.55, 1.50–1.61, I2 = 0%), and all-cause mortality (pHR including 1.031.472 patients: 1.56, 1.34–1.82, I2 = 99%). Prediabetes was associated with an increased risk for composite events (pHR including 8,262 patients: 1.50, 1.15–1.96, I2 = 0%) and recurrent stroke (pHR including 10,429 patients: 1.50, 1.18–1.91, I2 = 0), however, not with mortality (pHR including 9,378 patients, 1.82, 0.73–4.57, I2 = 78%). Insulin resistance was associated with recurrent stroke (pHR including 21,363 patients: 1.56, 1.19–2.05, I2 = 55%), but not with mortality (pHR including 21,363 patients: 1.31, 0.66–2.59, I2 = 85%).

Discussion

DM is associated with a 56% increased relative risk of death after IS and TIA. Risk estimates regarding recurrent events are similarly high between prediabetes and DM, indicating high cardiovascular risk burden already in precursor stages of DM. There was a high heterogeneity across most outcomes.
Using eye tracking to assess learning of a multifunction prosthetic hand: an exploratory study from a rehabilitation perspective
Authors: Hill Wendy , Lindner Helen
Published: August 2024

Background

Eye tracking technology not only reveals the acquisition of visual information at fixation but also has the potential to unveil underlying cognitive processes involved in learning to use a multifunction prosthetic hand. It also reveals gaze behaviours observed during standardized tasks and self-chosen tasks. The aim of the study was to explore the use of eye tracking to track learning progress of multifunction hands at two different time points in prosthetic rehabilitation.

Methods

Three amputees received control training of a multifunction hand with new control strategy. Detailed description of control training was collected first. They wore Tobii Pro2 eye-tracking glasses and performed a set of standardized tasks (required to switch to different grips for each task) after one day of training and at one-year-follow-up (missing data for Subject 3 at the follow up due to socket problem). They also performed a self-chosen task (free to use any grip for any object) and were instructed to perform the task in a way how they would normally do at home. The gaze-overlaid videos were analysed using the Tobii Pro Lab and the following metrics were extracted: fixation duration, saccade amplitude, eye-hand latency, fixation count and time to first fixation.

Results

During control training, the subjects learned 3 to 4 grips. Some grips were easier, and others were more difficult because they forgot or were confused with the switching strategies. At the one-year-follow-up, a decrease in performance time, fixation duration, eye-hand latency, and fixation count was observed in Subject 1 and 2, indicating an improvement in the ability to control the multifunction hand and a reduction of cognitive load. An increase in saccade amplitude was observed in both subjects, suggesting a decrease in difficulty to control the prosthetic hand. During the standardized tasks, the first fixation of all three subjects were on the multifunction hand in all objects. During the self-chosen tasks, the first fixations were mostly on the objects first.

Conclusion

The qualitative data from control training and the quantitative eye tracking data from clinical standardized tasks provided a rich exploration of cognitive processing in learning to control a multifunction hand. Many prosthesis users prefer multifunction hands and with this study we have demonstrated that a targeted prosthetic training protocol with reliable assessment methods will help to lay the foundation for measuring functional benefits of multifunction hands.