bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Hyperbaric Oxygen Therapy on Sleep Quality, Drug Dosage, and Nerve Function in Patients with Sleep Disorders after Ischemic Cerebral Stroke
Authors: Wang Jinbiao , Wang Chunlin , Wu Xiaogang , Ma Tao , Guo Xuanming
Published: November 2022

Objective. To explore the effects of hyperbaric oxygen therapy (HOT) on sleep quality, drug dosage, and nerve function in patients with sleep disorders after ischemic cerebral stroke (ICS). Methods. A total of 120 patients with acute ICS and sleep disorders who came to our hospital for treatment from January 2019 to October 2021 were selected and divided into control and observation groups according to the random numbering method, with 60 cases in each group. Both groups were treated with sertraline and eszopiclone for treating insomnia. The control group was given routine treatment for ICS, and the observation group was additionally treated with HOT in addition to the control group. The sleep quality, the use of sleep medication, the neurological function score, and the levels of serum tumor necrosis factor-α (TNF-α), endothelin (ET), and neuropeptide Y (NPY) before and after treatment were compared between the two groups. Results. The levels of TNF-α, ET and NPY were not significantly different between the two groups of patients before treatment (

P
>
0.05

), and all of the above indicators decreased significantly in both groups after treatment, with the observation group being lower than the control group (

P
<
0.05

). There was no significant difference in the sleep quality scores of PSQI, ESS, and SBQ between the two groups before treatment (

P
>
0.05

), and the above indicators decreased significantly in both groups after treatment, with the observation group being lower than the control group (

P
<
0.05

). There was no significant difference in the dose of sleep medication used in the first day of treatment between the two groups (

P
>
0.05

), and the amount of sleep medication used in the observation group was significantly less than that in the control group after 14 d of treatment (

P
<
0.05

). There was no significant difference in the NIHSS scores between the two groups before treatment (

P
>
0.05

), and the scores of both groups decreased after treatment, and the scores of the observation group were significantly lower than those of the control group (

P
<
0.05

). Conclusion. Compared with routine treatment, the addition of HOT to treat patients with sleep disorders after ICS can significantly improve their sleep quality, reduce dosage of sleep drugs, reduce inflammatory level of brain tissue and nerve function damage, and improve their prognosis. Trial Registration. This study was registered in the EA2019056
Inhibition of MicroRNA-182/183 Cluster Ameliorates Schizophrenia by Activating the Axon Guidance Pathway and Upregulating DCC
Authors: Wang Zhichao , Su Lin , Wu Tong , Sun Lei , Sun Zhenghai , Wang Yuchen , Li Ping , Cui Guangcheng
Published: November 2022

Schizophrenia (SZ) is a complex disorder caused by a variety of genetic and environmental factors. Mounting evidence suggests the involvement of microRNAs (miRNAs) in the pathology of SZ. Accordingly, the current study set out to investigate the possible implication of the miR-182/183 cluster, as well as its associated mechanism in the progression of SZ. Firstly, rat models of SZ were established by intraperitoneal injection of MK-801. Moreover, rat primary hippocampal neurons were exposed to MK-801 to simulate injury of hippocampal neurons. The expression of miR-182/183 or its putative target gene DCC was manipulated to examine their effects on SZ in vitro and in vivo. It was found that miR-182 and miR-183 were both highly expressed in peripheral blood of SZ patients and hippocampal tissues of SZ rats. In addition, the miR-182/183 cluster could target DDC and downregulate the expression of DDC. On the other hand, inhibition of the miR-182/183 cluster ameliorated SZ, as evidenced by elevated serum levels of NGF and BDNF, along with reductions in spontaneous activity, serum GFAP levels, and hippocampal neuronal apoptosis. Additionally, DCC was found to activate the axon guiding pathway and influence synaptic activity in hippocampal neurons. Collectively, our findings highlighted that inhibition of the miR-182/183 cluster could potentially attenuate SZ through DCC-dependent activation of the axon guidance pathway. Furthermore, inhibition of the miR-182/183 cluster may represent a potential target for the SZ treatment.
Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305
Authors: Kinneer Krista , Wortmann Philipp , Cooper Zachary A. , Dickinson Niall J. , Masterson Luke , Cailleau Thais , Hutchinson Ian , Vijayakrishnan Balakumar , McFarlane Mary , Ball Kathryn , Davies Michael , Lewis Arthur , Huang Yue , Rosenbaum Anton I. , Yuan Jiaqi , Chesebrough Jon , Anderton Judith , Monks Noel , Novick Steven , Wang Jixin , Dimasi Nazzareno , Christie R. James , Sabol Darrin , Tosto Frances Anne , Wallez Yann , Leo Elisabetta , Albertella Mark R. , Staniszewska Anna D. , Tice David A. , Howard Philip W. , Luheshi Nadia , Sapra Puja
Published: November 2022

Purpose:

We evaluated the activity of AZD8205, a B7-H4–directed antibody–drug conjugate (ADC) bearing a novel topoisomerase I inhibitor (TOP1i) payload, alone and in combination with the PARP1-selective inhibitor AZD5305, in preclinical models.

Experimental Design:

IHC and deep-learning–based image analysis algorithms were used to assess prevalence and intratumoral heterogeneity of B7-H4 expression in human tumors. Several TOP1i-ADCs, prepared with Val-Ala or Gly–Gly–Phe–Gly peptide linkers, with or without a PEG8 spacer, were compared in biophysical, in vivo efficacy, and rat toxicology studies. AZD8205 mechanism of action and efficacy studies were conducted in human cancer cell line and patient-derived xenograft (PDX) models.

Results:

Evaluation of IHC-staining density on a per-cell basis revealed a range of heterogeneous B7-H4 expression across patient tumors. This informed selection of bystander-capable Val-Ala–PEG8–TOP1i payload AZ14170133 and development of AZD8205, which demonstrated improved stability, efficacy, and safety compared with other linker–payload ADCs. In a study of 26 PDX tumors, single administration of 3.5 mg/kg AZD8205 provided a 69% overall response rate, according to modified RECIST criteria, which correlated with homologous recombination repair (HRR) deficiency (HRD) and elevated levels of B7-H4 in HRR-proficient models. Addition of AZD5305 sensitized very low B7-H4–expressing tumors to AZD8205 treatment, independent of HRD status and in models representing clinically relevant mechanisms of PARPi resistance.

Conclusions:

These data provide evidence for the potential utility of AZD8205 for treatment of B7-H4–expressing tumors and support the rationale for an ongoing phase 1 clinical study (NCT05123482).

See related commentary by Pommier and Thomas, p. 991
IL1β Expression Driven by Androgen Receptor Absence or Inactivation Promotes Prostate Cancer Bone Metastasis
Authors: DiNatale Anthony , Worrede Asurayya , Iqbal Waleed , Marchioli Michael , Toth Allison , Sjöström Martin , Zhu Xiaolin , Corey Eva , Feng Felix Y. , Zhou Wanding , Fatatis Alessandro
Published: November 2022

We report the inverse association between the expression of androgen receptor (AR) and IL1β in a cohort of patients with metastatic castration-resistant prostate cancer. We also discovered that AR represses the IL1β gene by binding an androgen response element half-site located within the promoter, which explains the IL1β expression in AR-negative (ARNEG) cancer cells. Consistently, androgen depletion or AR-pathway inhibitors (ARI) derepressed IL1β in AR-positive cancer cells, both in vitro and in vivo. The AR transcriptional repression is sustained by histone deacetylation at the H3K27 mark in the IL1β promoter. Notably, patients’ data suggest that DNA methylation prevents IL1β expression, even if the AR-signaling axis is inactive. Our previous studies show that secreted IL1β supports metastatic progression in mice by altering the transcriptome of tumor-associated bone stroma. Thus, in patients with prostate cancer harboring ARNEG tumor cells or treated with androgen-deprivation therapy/ARIs, and with the IL1β gene unmethylated, IL1β could condition the metastatic microenvironment to sustain disease progression.

Significance:

IL1β plays a crucial role in promoting skeletal metastasis. The current standard of care for patients with prostate cancer inhibits the AR-signaling axis in tumor cells and will consequently unleash IL1β production. Thus, hormonal deprivation and AR inhibitors should be combined with targeting IL1β signaling, and screening for DNA methylation on the IL1β locus will identify patients that benefit the most from this approach.
Lung Tumor Skin Metastasis: Case Report of a Solitary Cutaneous Ulcerated Lesion as Initial Manifestation of Lung Carcinoma
Authors: Falbo Francesco , Krizzuk Dimitri , Urciuoli Paolo , Biancucci Andrea , Galiffa Giampaolo , Donello Claudia , Esposito Anna , Mongardini Federico Maria , Sammartino Francesco
Published: November 2022

Lung cancer has the highest cancer incidence, and it is the most common cause of cancer death worldwide. Cutaneous metastases are infrequent compared to hilar nodes, adrenal glands, liver, brain, and bones. However, unusual skin lesions in patients at high risk of lung cancer should be regarded carefully to rule out a metastatic manifestation of an occult primary site tumor. Surgical excision, or incisional biopsy when the former is deemed unfeasible, should be performed to allow histopathological examination in case of occult primary site. In patients affected by advanced lung tumors, surgical excision could be beneficial in terms of pain control and improvement of the quality of life. We report a case of a solitary large skin lesion as an early manifestation of a lung adenocarcinoma.
Potential Implications of Exercise Training on Pannexin Expression and Function
Authors: Wakefield Brent , Penuela Silvia
Published: November 2022

Pannexins (PANX1, 2, 3) are channel-forming glycoproteins that are expressed throughout the cardiovascular and musculoskeletal system. The canonical function of these proteins is to release nucleotides that act as purinergic signalling at the cell membrane or Ca2+ channels at the endoplasmic reticulum membrane. These two forms of signalling are essential for autocrine and paracrine signalling in health, and alterations in this signalling have been implicated in the pathogenesis of many diseases. Many musculoskeletal and cardiovascular diseases are largely the result of a lack of physical activity which causes altered gene expression. Considering exercise training has been shown to alter a wide array of gene expression in musculoskeletal tissues, understanding the interaction between exercise training, gene function and expression in relevant diseases is warranted. With regards to pannexins, multiple publications have shown that exercise training can influence pannexin expression and may influence the significance of its function in certain diseases. This review further discusses the potential interaction between exercise training and pannexin biology in relevant tissues and disease models. We propose that exercise training in relevant animal and human models will provide a more comprehensive understanding of the implications of pannexin biology in disease.
Observational, Multicenter Study on the Efficacy, Tolerability, and Safety of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis Older than 80 Years
Authors: Mondoni Michele , Alfano Fausta , Varone Francesco , Muscato Giuseppe , Conti Caterina , Saderi Laura , Chiesa Amerigo , Di Marco Fabiano , Vancheri Carlo , Richeldi Luca , Centanni Stefano , Sotgiu Giovanni
Published: November 2022

Background: Idiopathic pulmonary fibrosis (IPF) primarily affects old patients. Old age is a predictor of mortality. Nintedanib, the only antifibrotic drug approved in Italy for patients aged >80 years, can slow the progression of IPF by reducing the rate of decline in forced vital capacity (FVC) and the risk of exacerbations. Objectives: The primary aim of the study was to compare the decline of FVC after 12 months of nintedanib in patients aged >80 years versus younger patients. Differences related to other functional data, safety, tolerability, hospitalizations, exacerbations, and mortality were evaluated. Methods: An observational, retrospective, multicenter study was carried out in Italy. Results: 159 (122 [76.7%] males) patients were recruited: 106 (66.7%) aged ≤80 years and 53 (33.3%) aged >80 years. FVC decline after 12 months of therapy was not significantly different (−45 mL [−170; 75] vs. −20 mL [−138; 110] mL; p: 0.51). No differences were found for other functional data. Diarrhea was the most frequent adverse event (AE). Rate and type of any AEs, permanent/temporary dose reduction, or drug discontinuation were not significantly different between patients aged ≤80 vs. >80 years. Furthermore, acute exacerbations, hospitalization, and mortality were not significantly different. Conclusions: Nintedanib is effective and safe in patients with IPF aged >80 years, and no significant differences were found when clinical outcomes were compared with those of younger patients. Thus, older age should not be a barrier for the early prescription of antifibrotic treatment in IPF patients.
Solitary Metastases Presentation from Uveal Melanoma: Report of 3 Cases and a Comprehensive Review of the Literature
Authors: Pereira Patrícia M. , Luís Ana , Passos Maria José , Gouveia Emanuel
Published: November 2022

Introduction: Uveal melanoma (UM) is a rare condition accounting for only 5% of all primary melanoma cases. Still, it is the most frequently diagnosed primary intraocular malignant tumor in adults. UM is an aggressive malignancy that originates from melanocytes in the eye. UMs are usually initiated by a mutation in GNAQ or GNA11, and rarely harbor a BRAF or NRAS mutations like cutaneous melanomas. Even if the primary tumor has been successfully treated with radiation or surgery, up to half of all UM patients will eventually develop metastatic disease. The liver is the most frequent metastatic site, and solitary metastases are rare, especially without hepatic or other organs (such as lung or skin/soft tissue) involvement. Most of treatment options to the metastatic UM are still inadequate in preventing a fatal outcome. Methods: A chart review of patients diagnosed with UM between January 1998 and December 2018 at the Instituto Português de Oncologia de Lisboa Francisco Gentil was performed. Results: Three patients with solitary metastases several years after primary UV treatment without any other organ involvement were identified. Patient 1 and 2 showed a very long overall survival and progression-free survival after complete surgical removal of the isolated metastatic lesion from colon and spleen, respectively. The third patient presented with a single brain metastasis from choroidal melanoma harboring the BRAF V600E mutation, a condition rarely reported in UM. Discussion: The cases highlight long relapse-free survival of UM; hence, a regular long-term follow-up should be mandatory. In addition, solitary metastases from UM should be treated, whenever possible, with a surgical approach, with complete removal as a goal.
Acute Retinal Pigment Epitheliitis following Vaccination
Authors: Sasajima Hirofumi , Zako Masahiro , Aoyagi Akari , Ueta Yoshiki , Suzuki Takafumi
Published: November 2022

We present a rare case of acute retinal pigment epitheliitis (ARPE) following vaccination. An 18-year-old Japanese man visited our hospital with a 5-day history of a central scotoma in the right eye. He had received the second dose of coronavirus disease 2019 vaccination (BNT162b2 mRNA, Pfizer-BioNTech) 1 month prior, following which he developed a low-grade fever of 37.3–37.5°C for 2 days accompanied by joint pain. Although he had received influenza vaccination 5 days prior to this presentation, no systemic symptoms other than injection site pain were observed. Blood test results were unremarkable. Ophthalmological examination revealed a decimal best-corrected visual acuity (BCVA) of 0.8 and 1.2 in the right and left eyes, respectively. Intraocular pressure was 15 mm Hg in both eyes. Intraocular inflammation was not observed. Fundus examination revealed a localized lesion of pigment stippling associated with yellowish hypopigmentation in the fovea. Fluorescein angiography revealed slight transmission hyperfluorescence without leakage. Optical coherence tomography (OCT) revealed disruption of the external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ). We diagnosed the patient with ARPE in the right eye. The patient was followed up without treatment. Five weeks after onset, the central scotoma in the right eye disappeared, and patient’s BCVA in the right eye improved to 1.5. OCT showed improvement in ELM and EZ continuity in the right eye, but IZ remained disruptive. Although the exact pathophysiology of the association between ARPE and these vaccinations is unclear, ARPE may develop after the vaccination.
Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study
Authors: Wang Yiying , Ye Chaojie , Kong Lijie , Zheng Jie , Xu Min , Xu Yu , Li Mian , Zhao Zhiyun , Lu Jieli , Chen Yuhong , Wang Weiqing , Ning Guang , Bi Yufang , Wang Tiange
Published: November 2022

Background:

Education, intelligence, and cognition are associated with hypertension, but which one plays the most prominent role in the pathogenesis of hypertension and which modifiable risk factors mediate the causal effects remains unknown.

Methods:

Using summary statistics of genome-wide association studies of predominantly European ancestry, we conducted 2-sample multivariable Mendelian randomization to estimate the independent effects of education, intelligence, or cognition on hypertension (FinnGen study, 70 651 cases/223 663 controls; UK Biobank, 77 723 cases/330 366 controls) and blood pressure (International Consortium of Blood Pressure, 757 601 participants), and used 2-step Mendelian randomization to evaluate 25 potential mediators of the association and calculate the mediated proportions.

Results:

Meta-analysis of inverse variance weighted Mendelian randomization results from FinnGen and UK Biobank showed that genetically predicted 1-SD (4.2 years) higher education was associated with 44% (95% CI: 0.40–0.79) decreased hypertension risk and 1.682 mm Hg lower systolic and 0.898 mm Hg lower diastolic blood pressure, independently of intelligence and cognition. While the causal effects of intelligence and cognition on hypertension were not independent of education; 6 out of 25 cardiometabolic risk factors were identified as mediators of the association between education and hypertension, ranked by mediated proportions, including body mass index (mediated proportion: 30.1%), waist-to-hip ratio (22.8%), body fat percentage (14.1%), major depression (7.0%), high-density lipoprotein cholesterol (4.7%), and triglycerides (3.4%). These results were robust to sensitivity analyses.

Conclusions:

Our findings illustrated the causal, independent impact of education on hypertension and blood pressure and outlined cardiometabolic mediators as priority targets for prevention of hypertension attributable to low education.
Dynamics of Functional Networks for Syllable and Word-Level Processing
Authors: Rimmele Johanna M. , Sun Yue , Michalareas Georgios , Ghitza Oded , Poeppel David
Published: November 2022

Speech comprehension requires the ability to temporally segment the acoustic input for higher-level linguistic analysis. Oscillation-based approaches suggest that low-frequency auditory cortex oscillations track syllable-sized acoustic information and therefore emphasize the relevance of syllabic-level acoustic processing for speech segmentation. How syllabic processing interacts with higher levels of speech processing, beyond segmentation, including the anatomical and neurophysiological characteristics of the networks involved, is debated. In two MEG experiments, we investigate lexical and sublexical word-level processing and the interactions with (acoustic) syllable processing using a frequency-tagging paradigm. Participants listened to disyllabic words presented at a rate of 4 syllables/s. Lexical content (native language), sublexical syllable-to-syllable transitions (foreign language), or mere syllabic information (pseudo-words) were presented. Two conjectures were evaluated: (i) syllable-to-syllable transitions contribute to word-level processing; and (ii) processing of words activates brain areas that interact with acoustic syllable processing. We show that syllable-to-syllable transition information compared to mere syllable information, activated a bilateral superior, middle temporal and inferior frontal network. Lexical content resulted, additionally, in increased neural activity. Evidence for an interaction of word- and acoustic syllable-level processing was inconclusive. Decreases in syllable tracking (cerebroacoustic coherence) in auditory cortex and increases in cross-frequency coupling between right superior and middle temporal and frontal areas were found when lexical content was present compared to all other conditions; however, not when conditions were compared separately. The data provide experimental insight into how subtle and sensitive syllable-to-syllable transition information for word-level processing is.
Typification of Sagina ciliata and S. stricta (Caryophyllaceae), two taxa described from Sweden, and notes on the taxonomy of the S. apetala complex
Authors: THULIN MATS
Published: November 2022

N/A
The millipede family Striariidae Bollman, 1893. VI. Six new genera and thirteen new species from western North America (Diplopoda, Chordeumatida, Striarioidea)
Authors: SHEAR WILLIAM A. , MAREK PAUL E.
Published: November 2022

The following new genera and species of Striariidae are described from the states of California, Oregon and Washington: Nototrisaria ornata n. gen., n. sp., Maraplia napa n. gen., n. sp., Maraplia chico n. gen., n. sp., Maraplia schusteri n. gen., n. sp., Lamparia curryensis n. gen., n. sp., Lamparia bentonensis n. gen., n. sp., Lamparia pratensis n. gen., n. sp., Lamparia millicoma n. gen., n. sp., Rampalia cheathamensis n. gen., n. sp., Plaramia arcata n. gen., n. sp., Plaramia johnsonae n. gen., n. sp., Ralampia complexa n. gen., n. sp., and Ralampia filamentosa n. gen., n. sp.. The new species are all very small millipedes, 5.5 mm or less in length and with two or three ommatidia on each side of the head or blind. The majority have the sixth metazonital crest larger than the other crests and extended horizontally, so that the animals have the general appearance of having paranota. A new key to striariid genera is presented.
A new species of the genus Protohyale Bousfield & Hendrycks, 2002 (Crustacea, Amphipoda, Hyalidae) from Covelong, Chennai, India
Authors: RAUT SHRUTIKA , PRAKASH SANJEEVI , ARJUNAN VINUGANESH , KUMAR AMIT
Published: November 2022

A new species of marine amphipod, Protohyale covelongensis sp. nov., is described from India. The taxon is fully described and illustrated with which it could be easily identified morphologically. Protohyale covelongensis sp. nov. has a specific shape of the basis of pereopod 7 in the mature male, forming a distinct axe-shaped flange on its anterior margin. This characteristic feature serves to distinguish it from other Indian hyalid species. This new species is also compared with known species with which it could be confused. We have performed molecular phylogeny based on the mitochondrial gene cytochrome c oxidase subunit I.
Lagrangian Overturning Pathways in the Eastern Subpolar North Atlantic
Authors: Tooth Oliver J. , Johnson Helen L. , Wilson Chris
Published: November 2022

The strength of the Atlantic meridional overturning circulation (AMOC) at subpolar latitudes is dominated by water mass transformation in the eastern subpolar North Atlantic Ocean (SPNA). However, the distribution of this overturning across the individual circulation pathways of both the Subpolar Gyre (SPG) and the Nordic seas overflows remains poorly understood. Here, we introduce a novel Lagrangian measure of the density-space overturning to quantify the principal pathways of the time-mean overturning circulation within an eddy-permitting ocean model hindcast. By tracing the trajectories of water parcels initialized from the northward inflows across the Overturning in the Subpolar North Atlantic Program (OSNAP) East section, we show that water mass transformation along the pathways of the eastern SPG accounts for 55% of the mean strength of the eastern subpolar AMOC. Water parcels following the dominant SPG pathway, sourced from the Subarctic Front, form upper North Atlantic Deep Water by circulating horizontally across sloping isopycnals in less than 2 years. A slower SPG route, entrained by overflow waters south of the Iceland–Faroes Ridge, is a crucial conduit for subtropical-origin water masses to penetrate the deep ocean on subdecadal time scales. On reproducing our findings using time-averaged velocity and hydrographic fields, we further show that the Nordic seas overflow pathways integrate multiple decades of water mass transformation before returning across the Greenland–Scotland Ridge. We propose that the strong disparity between the overturning time scales of the SPG (interannual) and the Nordic seas overflows (multidecadal) has important implications for the propagation of density anomalies within the eastern SPNA and hence the sources of AMOC variability.
Linking Large-Scale Double-ITCZ Bias to Local-Scale Drizzling Bias in Climate Models
Authors: Zhou Wenyu , Leung L. Ruby , Lu Jian
Published: November 2022

Tropical precipitation in climate models presents significant biases in both the large-scale pattern (i.e., double intertropical convergence zone bias) and local-scale characteristics (i.e., drizzling bias with too frequent drizzle/convection and reduced occurrences of no and heavy precipitation). By untangling the coupled system and analyzing the biases in precipitation, cloud, and radiation, this study shows that local-scale drizzling bias in atmospheric models can lead to large-scale double-ITCZ bias in coupled models by inducing convective-regime-dependent biases in precipitation and cloud radiative effects (CRE). The double-ITCZ bias consists of a hemispherically asymmetric component that arises from the asymmetric SST bias and a nearly symmetric component that exists in atmospheric models without the SST bias. By increasing light rain but reducing heavy rain, local-scale drizzling bias induces positive (negative) precipitation bias in the moderate (strong) convective regime, leading to the nearly symmetric wet bias in atmospheric models. By affecting the cloud profile, local-scale drizzling bias induces positive (negative) CRE bias in the stratocumulus (convective) regime in atmospheric models. Because the stratocumulus (convective) region is climatologically more pronounced in the southern (northern) tropics, the CRE bias is deemed to be hemispherically asymmetric and drives warm and wet (cold and dry) biases in the southern (northern) tropics when coupled to ocean. Our results suggest that correcting local-scale drizzling bias is critical for fixing large-scale double-ITCZ bias. The drizzling and double-ITCZ biases are not alleviated in models with mesoscale (0.25°–0.5°) or even storm-resolving (∼3 km) resolution, implying that either large-eddy simulation or fundamental improvement in small-scale subgrid parameterizations is needed.
Modulation by the QBO of the Relationship between the NAO and Northeast China Temperature in Late Winter
Authors: Zuo Jinqing , Xie Fei , Yang Liuni , Sun Chenghu , Wang Lin , Zhang Ruhua
Published: November 2022

The North Atlantic Oscillation (NAO) generally has an in-phase relationship with surface air temperature (SAT) anomalies over Northeast China in late winter. The present study shows that such an NAO–SAT relationship becomes stronger during easterly phases of the quasi-biennial oscillation (QBO), but is relatively weak during westerly phases. Observational evidence reveals that the modulation effect of the QBO on the NAO–SAT relationship over Northeast China is attributable to QBO-induced changes in the spatial structure of the NAO and associated stratosphere–troposphere coupling. During easterly QBO phases, the NAO has a strong connection with the Northern Hemisphere stratospheric polar vortex, facilitating a hemisphere-wide structure of the NAO and thus a downstream extension of NAO signal from the Euro–Atlantic sector toward Northeast Asia. During westerly QBO phases, however, the NAO has a limited connection with the stratospheric polar vortex. In this case, the NAO features a classically regional mode, with the signal in the SAT field mainly confined to the Euro-Atlantic sector. By examining historical simulations from six climate models participating in CMIP6 and including stratospheric processes, it is found that none of these models captures a significant difference in the spatial structure of the NAO and its connection with the stratospheric polar vortex between the easterly and westerly QBO phases in late winter. A key reason may be related to the poor performance of the models in simulating the Holton–Tan effect, which is critical for linking the QBO and NAO.

Significance Statement

The QBO is the dominant mode of equatorial stratospheric variability and important for seasonal forecasting. This study aims to better understand the surface influence of the QBO by examining the relationship between the NAO and temperature anomalies over China according to the phases of the QBO during boreal winter. Our results highlight the importance of the QBO in modulating the spatial structure and thus climate impact of the NAO via stratosphere–troposphere coupling in observations, while state-of-the-art climate models perform poorly in simulating the QBO-related stratosphere–troposphere coupling and thus the QBO–NAO connection. These findings have important implications for seasonal prediction and model development in the future.
Simulated Mid-Holocene and Last Interglacial Climate Using Two Generations of AWI-ESM
Authors: Shi Xiaoxu , Werner Martin , Wang Qiang , Yang Hu , Lohmann Gerrit
Published: November 2022

Numerical simulations allow us to gain a comprehensive understanding of the underlying mechanisms of past, present, and future climate changes. The mid-Holocene (MH) and the last interglacial (LIG) were the two most recent warm episodes of Earth’s climate history and are the focus of paleoclimate research. Here, we present results of MH and LIG simulations with two versions of the state-of-the-art Earth system model AWI-ESM. Most of the climate changes in MH and LIG compared to the preindustrial era are agreed upon by the two model versions, including 1) enhanced seasonality in surface temperature that is driven by the redistribution of seasonal insolation; 2) a northward shift of the intertropical convergence zone (ITCZ) and tropical rain belt; 3) a reduction in annual mean Arctic sea ice concentration; 4) weakening and northward displacement of the Northern Hemisphere Hadley circulation, which is related to the decrease and poleward shift of the temperature gradient from the subtropical to the equator in the Northern Hemisphere; 5) a westward shift of the Indo-Pacific Walker circulation due to anomalous warming over the Eurasia and North Africa during boreal summer; and 6) an expansion and intensification of Northern Hemisphere summer monsoon rainfall, with the latter being dominated by the dynamic component of moisture budget (i.e., the strengthening of wind circulation). However, the simulated responses of the Atlantic meridional overturning circulation (AMOC) in the two models yield different results for both the LIG and the MH. AMOC anomalies between the warm interglacial and preindustrial periods are associated with changes in North Atlantic westerly winds and stratification of the water column at the North Atlantic due to changes in ocean temperature, salinity, and density.
Can DSD Assumptions Explain the Differences in Satellite Estimates of Warm Rain?
Authors: Schulte Richard M. , Kummerow Christian D.
Published: November 2022

Satellite-based oceanic precipitation estimates, particularly those derived from the Global Precipitation Measurement (GPM) satellite and CloudSat, suffer from significant disagreement over regions of the globe where warm rain processes are dominant. GPM estimates of average rain rate tend to be lower than CloudSat estimates, due in part to GPM being less sensitive to shallow and/or light precipitation. Using coincident observations between GPM and CloudSat, we find that the GPM_2BCMB product misses about two-thirds of total accumulated warm rain compared to the CloudSat 2C-RAIN-PROFILE product. This difference becomes much smaller when products are compared at 1000 m above the surface (mitigating surface clutter issues) and when forcing the frequency of rain from CloudSat to match the frequency from GPM (mitigating sensitivity issues). However, even then a gap of about 25% remains. Using an optimal estimation retrieval algorithm on the underlying data, we retrieve a similar result, but find that the remaining difference between the GPM and CloudSat retrieved rain rates can be almost entirely accounted for by inconsistent assumptions about the shape of the drop size distribution (DSD) that are made in the two retrievals. We conclude that DSD assumptions contribute significantly to the relative underestimation of warm rain by GPM compared to CloudSat. Because the choice of DSD model has such a large effect on retrieved rain rates, more work is needed to determine whether the DSD models assumed by either the GPM_2BCMB or 2C-RAIN-PROFILE algorithms are actually appropriate for warm rain.
Assimilation of New York State Mesonet Surface and Profiler Data for the 21 June 2021 Convective Event
Authors: Lin Hsiao-Chun , Sun Juanzhen , Weckwerth Tammy M. , Joseph Everette , Kay Junkyung
Published: November 2022

The New York State Mesonet (NYSM) has provided continuous in situ and remote sensing observations near the surface and within the lower troposphere since 2017. The dense observing network can capture the evolution of mesoscale motions with high temporal and spatial resolution. The objective of this study was to investigate whether the assimilation of NYSM observations into numerical weather prediction models could be beneficial for improving model analysis and short-term weather prediction. The study was conducted using a convective event that occurred in New York on 21 June 2021. A line of severe thunderstorms developed, decayed, and then reintensified as it propagated eastward across the state. Several data assimilation (DA) experiments were conducted to investigate the impact of NYSM data using the operational DA system Gridpoint Statistical Interpolation with rapid update cycles. The assimilated datasets included National Centers for Environmental Prediction Automated Data Processing global upper-air and surface observations, NYSM surface observations, Doppler lidar wind retrievals, and microwave radiometer (MWR) thermodynamic retrievals at NYSM profiler sites. In comparison with the control experiment that assimilated only conventional data, the timing and location of the convection reintensification was significantly improved by assimilating NYSM data, especially the Doppler lidar wind data. Our analysis indicated that the improvement could be attributed to improved simulation of the Mohawk–Hudson Convergence. We also found that the MWR DA resulted in degraded forecasts, likely due to large errors in the MWR temperature retrievals. Overall, this case study suggested the positive impact of assimilating NYSM surface and profiler data on forecasting summertime severe weather.
A Comparative Study of Various Approaches for Producing Probabilistic Forecasts of Upper-Level Aviation Turbulence
Authors: Shin Hyeyum Hailey , Deierling Wiebke , Sharman Robert
Published: November 2022

The skill of operational deterministic turbulence forecasts is impacted by the uncertainties in both weather forecasts from the underlying numerical weather prediction (NWP) models and diagnoses of turbulence from the NWP model output. This study compares various probabilistic turbulence forecasting approaches to quantify these uncertainties and provides recommendations on the most suitable approach for operational implementation. The approaches considered are all based on ensembles of NWP forecasts and/or turbulence diagnostics, and include a multi-diagnostic ensemble (MDE), a time-lagged NWP ensemble (TLE), a forecast-model NWP ensemble (FME), and combined time-lagged MDE (TMDE) and forecast-model MDE (FMDE). Both case studies and statistical analyses are provided. The case studies show that the MDE approach that represents the uncertainty in turbulence diagnostics provides a larger ensemble spread than the TLE and FME approaches that represent the uncertainty in NWP forecasts. The larger spreads of MDE, TMDE, and FMDE allow for higher probabilities of detection for low percentage thresholds at the cost of increased false alarms. The small spreads of TLE and FME result in either hits with higher confidence or missed events, highly dependent on the performance of the underlying NWP model. Statistical evaluations reveal that increasing the number of diagnostics in MDE is a cost-effective and powerful method for describing the uncertainty of turbulence forecasts, considering trade-offs between accuracy and computational cost associated with using NWP ensembles. Combining either time-lagged or forecast-model NWP ensembles with MDE can further improve prediction skill and could be considered if sufficient computational resources are available.
Astronauts’ Sensemaking of Dangerous Beauty: An Account of the Overview Effect for Organizational Theory
Authors: Rush Katherine Ann
Published: November 2022

In this article, I explore sensemaking processes associated with the overview effect—a cognitive shift experienced by astronauts who see Earth from space. Analysis of publicly available interviews ( n  = 51) with astronauts revealed a common sequence of sensemaking: First, astronauts reported experiencing speechlessness triggered by beauty and awe (a phenomenon I label, awe-mute). Second, during and after missions, most reported attempting to make sense of the experience with others, often resulting in a deepening of their previously-existing worldviews, a process I term sensedeepening. Third, sensedeepening often resulted in astronauts’ (a) admissions of inadequacy to give sense to their experience for others, and despite this, (b) development of messages to communicate their experiences, and (c) engagement in social activism. These patterns were corroborated by additional interviews with astronauts ( n  = 5) and an interview with a prolific interviewer of astronauts. Implications for sensemaking theory and organizational change conclude the article.
Coloniality as Appropriation of Indigenous Ontologies: Insights From South Africa and Ethiopia
Authors: Eybers Oscar Oliver
Published: November 2022

The purpose of this investigation is to frame Global North colonialism in southern and eastern Africa as ontological appropriation. In the article’s conceptual framework, ontological appropriation is colonial claims to aspects of African realities without acknowledgment of their original sources and creators. In the case of southern Africa, Global North appropriation of Khoi and San agriculturalist ontologies is illustrated. Additionally, attempts by the Global North to claim origination of Ethiopia’s ancient ontologies are cited as evidence of colonial appropriation. In accordance, the methods of the investigation involved a review of scholarship related to indigenous ontologies in South and East Africa. Moreover, scholarly voices speaking to epistemic encounters between the Global North with Africans are observed. Thus, a thesis of ontological appropriation is generated. Results of the investigation indicate sustained Global North warfare, and epistemic assaults led to the fall of Khoi, San, hunter-gather, and pastoral ontologies in the South. In contrast, in the East Ethiopia’s ancient theocracy, and monarchies prevented Global North acquisition of land, and ontic dominance. The article concludes colonialism was a deliberate attempt to modify, and control African ontologies. As a result, in southern Africa Khoi San ontologies transformed from hunter-gatherers, and pastoralists to colonial servitude. In Ethiopia, however, monarchical, and theocratic ontologies are vibrant to the present age. Hence, this article’s contribution to new knowledge is its accentuation of divergent hunter-gatherer, pastoralist, and monarchical responses to colonialism in ways that enabled, and resisted colonial appropriation of indigenous ontologies.
How Do Looming and Receding Emotional Faces Modulate Duration Perception?
Authors: Min Yeji , Kim Sung-Ho
Published: November 2022

The direction of visual motion has been shown to affect the perception of interval duration; objects moving towards an observer (i.e., looming) are perceived to last longer than objects moving away (i.e., receding), and this has been explained in terms of arousal- or attention-based modulation. To dissociate the two competing accounts, we investigated how the influence of motion direction on duration perception is modulated by the emotional content of stimuli. Participants were given the temporal bisection task with images of emotional faces (angry, happy, and neutral) presented in a static (Experiment 1) or dynamic (Experiment 2) display. In Experiment 1, we found no influence of facial emotion on perceived duration. In Experiment 2, however, looming (i.e., expanding) stimuli were perceived as lasting longer than receding (contracting) ones. More importantly, we found an interaction between participant-rated arousal to faces and motion direction: The looming/receding asymmetry was pronounced when the stimulus arousal was rated low, but this asymmetry diminished with increasing arousal ratings. Thus, looming/receding temporal asymmetry seems to be reduced when arousing facial expressions enhance attentional engagement.
Knowledge about relationship of diets with non-communicable disease and prospects for amelioration by consuming mushrooms in South-East Nigeria
Authors: Ogbo Frank C , Chukwuanukwu Rebecca C , Okafoanyali James Ogochukwu
Published: November 2022

Background: Knowledge plays a key role in shaping people's attitudes and behaviors to adopt healthy lifestyles, which is important in any program of NCD prevention. There is no data about how much the general public in South-East Nigeria (SE) knows about how their diets may dispose or help them prevent NCDs. Aim: This study aims to assess knowledge available on the relationship between NCDs and diets/foods including mushrooms among the general public of SE Nigeria. Methods: Data was collected using the survey questionnaire and interview method in the five SE States: Abia, Anambra, Ebonyi, Enugu, and Imo States. Simple descriptive statistics were used to analyze data. Results: A total of 846 responses were received from 1000 questionnaires. Proportion of respondents who knew (p^yes) about a relationship between diets and NCDs was 51.5%. p^yes was significantly higher among males than females and increased with age and level of education of respondents. It also varied among the States of SE Nigeria. Knowledge scores based on a scale of 0–5 revealed that respondents knew more about foods, which can reduce (2.3 ± 0.102) e.g., fruits/vegetables, than can increase (1.9 ± 0.096) e.g., sugary/starchy foods, the risk of NCDs. Varying proportions of respondents in all States of the SE knew that mushroom consumption can ameliorate NCDs. Conclusion: This study reveals that half of population of SE Nigeria knows about the relationship between diets and NCDs. A significant proportion also knows that mushroom consumption can ameliorate NCDs suggesting prospects of its utilization in preventing NCDs.
Assessing the lidar revolution in the Maya lowlands: A geographic approach to understanding feature classification accuracy
Authors: Garrison Thomas G , Thompson Amy E , Krause Samantha , Eshleman Sara , Fernandez-Diaz Juan C , Baldwin J Dennis , Cambranes Rafael
Published: November 2022

It has been well over a decade since lidar-based research began in earnest in the Maya Lowlands of southern Mexico, Guatemala, Belize, and Honduras. Most investigations have an archaeological focus, with a few integrating studies of the ancient Maya with analyses of local ecology and land-use. A review of frequently cited publications reveals a lack of consistency in assessing the accuracy of archaeological feature classifications in lidar data with variables such as sensor type, class definitions, and ground-truthing methods differentially affecting assessment results across the Lowlands. In general, area-based ground-truthing approaches to classifications of full waveform lidar data present the most comprehensive accuracy assessments. New assessment data from the Buenavista Valley of north-central Guatemala are presented to compare against existing studies and to demonstrate how a geographic approach (a comprehensive, landscape-scale study of features over space and time) to classification error assessment can enhance understanding of classification accuracy. Results show that meaningful comparisons of archaeological features across lidar datasets cannot be considered reliable without more uniform and detailed presentations of accuracy assessment methods, analyses, and results. The article concludes with recommendations for how such collaborations might proceed.
Identification of Urban Air Logistics Distribution Network Concepts
Authors: Rifan Rafhan , Adikariwattage Varuna , Barros Alexandre De
Published: November 2022

This study attempts to identify urban air logistics (UAL) operational concepts by synthesizing the urban freight transport (UFT) network configurations and urban air mobility (UAM) characteristics. UAL is gaining popularity as a quick and safe mode that has the potential to address several logistics challenges. This study has reviewed scientific papers identified using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework to understand the features of existing UFT distribution networks, unmanned aerial systems (UAS), and UAM. The cross analysis considered UFT features such as the parcel’s weight, delivery type (time sensitivity, customer-to-customer, business-to-consumer, or business-to-business), and UFT distribution network types and compared them against the features of UAS such as maximum take-off weight, range, and infrastructure requirements (drone ports). The analysis identified three types of UAL operational concepts: door-to-door direct (D2DD), hybrid, and multimodal. Lightweight deliveries can be operated using D2DD and hybrid through point-to-point (P-P) and extended P-P network concepts. The hybrid concept uses an intermediate drop-off location to deliver goods. Hub-and-spoke (H-S), extended H-S, and trunk line with collecting/distribution network designs can be used for heavyweight cargo operations. D2DD versus hybrid/multimodal concepts were compared based on six thematic clusters (societal implications, safety and security, ethics, environmental issues, public acceptance, and urban planning and infrastructure). This study identified that technological development and innovation could reduce social implications and ethical challenges. Furthermore, public willingness and economic feasibility will determine the success of the operational concepts. The identified UAL operational concepts, network designs, and challenges will help to conduct further research in this subject area.