bluuebunny/crossref_metadata_2025 huggingface dataset:
Fatty acid composition of mayonnaise based on sunflower, flax and hemp oil
Authors: Kryskova L. P. , Pokotylo O. S.
Published: July 2023

The features of the fatty acid composition of oils and mayonnaise samples prepared on the basis of sunflower, linseed and hemp oils were determined by the method of gas-liquid chromatography. The ratio between the content of PUFAs of the ω-9/ω-6/ω-3 families in the investigated sunflower oil samples was established, which was 177 : 553 : 1. This is caused by the high content of linoleic and oleic acids and the low content of α-linolenic acid (ω-3 ) in sunflower oil. In the studied samples of linseed oil, the content of α-linolenic acid was 52 %, and the content of oleic (ω-9) and linoleic (ω-6) acids was 22.3 and 16.2 %, respectively. Therefore, the ratio between PUFAs ω-9/ω-6/ω-3 in the studied samples of linseed oil was 1.4 : 1 : 3.2. In the tested samples of hemp oil, the content of linoleic acid (ω-6) was 55.7 %, and the content of α-linolenic acid (ω-3) and oleic acid (ω-9) was 18.2 % and 13.2 %, respectively. The ratio between ω-9/ω-6/ω-3 PUFAs in the tested hemp oil samples was 1.4 : 4.5 : 1. Research has established a high content of PUFAs of the ω-6 family and a low content of PUFAs of the ω-3 family in the control sample of mayonnaise (K), which is made using sunflower oil with a content of 71.78 %. This sample was characterized by the ratio of PUFAs of the ω-3, ω-6 and ω-9 families as 1 : 13 : 7.3. In the test sample of mayonnaise (D) containing 23.3 % each of sunflower, linseed and hemp oils, the total content of PUFAs of the ω-3 family was 24.1 %, which is 20.4 % more than in sample K. The higher content of PUFAs of the ω-3 family ω-3 in sample D is caused by the high content of α-linolenic acid in linseed and hemp oils. The total content of PUFAs of the ω-6 family in mayonnaise sample D was 47.4 %, and in sample K – 49.1 %. The content of PUFAs of the ω-9 family in sample D was 18.8 %, and in sample K – 26.9 %. Therefore, the ratio between the content of PUFAs of the ω-3/ω-6/ω-9 families in sample D was 1.3 : 2.5 : 1. The ratio between the content of PUFAs/PUFAs in mayonnaise sample D was 1 : 9.3, while in sample K – 1 : 4.5. Thus, replacing 2/3 of sunflower oil with linseed oil and hemp oil in equal parts in the technological process of making sample D of mayonnaise gives a number of positive advantages in the biological value of the product, compared to sample K, which contains only sunflower oil in its composition. This is a decrease in the content of PUFAs of the ω-6 family, an increase in the content of PUFAs of the ω-3 family, optimization of the balance between the content of PUFAs of the ω-3 / ω-6 / ω-9 families, a decrease in the content of saturated fatty acids and, accordingly, an increase in the content of unsaturated. The results of the analysis of the fatty acid composition of the mayonnaise D sample allow us to recommend this emulsion oil-fat product as a functional product due to the balanced ratio between the content of PUFAs of the ω-3 / ω-6 / ω-9 families.
Correlation between Leptin and Free Testosterone Levels in Transfusion-Dependent Thalassemia Male Patients
Authors: Lubis Dian Anindita , Karina Sugih Arto  , Heny Syahrini
Published: July 2023

Background: Male hypogonadism is a clinical disorder of low testosterone and spermatozoa due to impaired production that can occur at one or more levels in the hypothalamic-pituitary-gonadal (HPG) axis. Apart from iron accumulation, hypogonadism can also occur due to other mechanisms in thalassemia patients, such as the influence of adipose tissue and leptin. The study aimed to assess the relationship between leptin with free testosterone levels and BMI in transfusion-dependent thalassemia.
Method: The research design chosen was analytic cross-sectional. The study was conducted at the adult thalassemia polyclinic of Cipto Mangunkusumo General Hospital and Fatmawati General Hospital, during the period July - December 2022. The samples used were male transfusion-dependent thalassemia patients aged over 18 years who were under control at the Thalassemia Polyclinic during the study period. The diagnosis of Thalassemia had been previously established by high-performance liquid chromatography (HPLC) or microcapillary examination.
Result: Most patients were major ß thalassemia (87.8%), while HbE ß thalassemia was only 12.1%. Age distribution was with a median of 23 years (minimum-maximum 18-42 years). The clinical symptoms of hypogonadism were erectile dysfunction and decreased libido (12.1% and 9%, respectively). From body mass index examination were underweight 18 (54,5%), normal weight 13 (39,5%), overweight 1 (3%), and obese 1 (3%). Of the 33 transfusion-dependent thalassemia patients, 95% did not reach puberty according to their age (Tanner stage V).
Conclusion: There is an association significantly between leptin levels with free testosterone and body mass index in transfusion-dependent thalassemia men.
Pharmacotherapy of Hypertension in Chronic Dialysis Patients in USU Hospital Medan
Authors: Panjaitan Josep Henry , Gazaly Feldi
Published: July 2023

Background: Hypertension is closely related to chronic kidney disease (CKD) patients because hypertension can be a cause or a result of hemodialysis (HD). The way that can be done to control blood pressure is the administration of antihypertensive drugs. The use of antihypertensive drugs in CKD on HD patients in hospitals is needed as an evaluation material in terms of the accuracy and optimization of drug administration. This study aims to know the administration pattern of antihypertensive drugs used by the HD unit in USU Hospital Medan.
Method: Descriptive statistics were used to present the antihypertensive drug prescription pattern of CKD in HD patients. This study used data in the form of medical records and also direct interviews with patients and nurses of the HD Unit at USU Hospital in 2022.
Results: The most common single drug antihypertensive used was Calcium Channel Blocker (CCB) as amlodipine 67.4% either alone or in combination. The most common 2 drugs antihypertensive combination were Angiotensin Receptor Blocker (ARB) as candesartan and CCB as amlodipine 19.5%.
Conclusion: The most common single drug antihypertensive used was CCB, and the most common drugs antihypertensive in combination 2 drugs were CCB and ARB.
ФОРМУВАННЯ ПРОФЕСІЙНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ ЮРИСТІВ
Authors: Лещенко Геннадій , Бєляєва Анна
Published: July 2023

У статті розглядається проблема формування професійної компетентності майбутніх юристів. Запропоновано визначення поняття «професійна компетентність майбутніх юристів», представлені компоненти професійної компетентності майбутніх юристів: ціннісно-мотиваційний, когнітивно-діяльнісний, комунікативний, аналітично-рефлексивний. Для розв'язання проблеми формування професійної компетентності майбутніх юристів доцільним автори вбачають створення такої системи професійної підготовки, яка б передбачала цілісність, наступність та діалектичний взаємозв'язок всіх освітніх компонентів; спрямованість змісту кожного освітнього компонента, форм, методів і засобів навчання на формування професійної компетентності майбутніх юристів; максимальне наближення змісту освіти до потреб професійної діяльності, застосовуючи методи моделювання та імітації реальних виробничих ситуацій.
ТРАНСНАЦІОНАЛЬНІ БАНКИ: СУЧАСНИЙ СТАН ТА ПЕРСПЕКТИВИ ЇХ РОЗВИТКУ
Authors: Блащук-Дев’яткіна Наталія , Пилат Марта
Published: July 2023

У статті досліджено основні аспекти та теоретичні засади діяльності транснаціональних банків, окреслено основні елементи еволюції їх розвитку. Зазначено визначення транснаціональних банків згідно з методологією ООН та основні показники відповідно до вимог. Обґрунтовано визначення поняття «транснаціоналізації банківського капіталу». Розглянуто відносини, які відображає транснаціональний банківський капітал. Зазначено, що транснаціональний банк як різновид міжнародної кредитно-фінансової організації універсального типу виконує ряд функцій на підставі певних принципів та перелічено основні з них. Виділено основні характерні риси транснаціонального банку. Для того, щоб оцінити роль транснаціональних банків у структурі банківської системи України проаналізовано динаміку кількості банків в Україні протягом 2018-2023 рр., у тому числі банків з іноземним капіталом. Розглянуто рейтинг найбільших транснаціональних банків у світі у 2022 році, де зазначено, що Китай посідає провідне місце за кількістю ТНБ. Визначено, що найбільшими транснаціональними банками володіють також США, Японія, Франція, Великобританія. Проаналізовано рейтинг життєздатності банків України у 2023 році, згідно якого виділено банки з іноземним капіталом. Визначено материнські компанії наведених банків та окреслено основні риси функціонування. Визначено, що найбільш життєздатними в Україні є банки з материнськими компаніями у Франції, США, Нідерландах, Угорщині, Польщі, Німеччині, Греції тощо. Розглянуто позитивні та негативні наслідки діяльності транснаціональних банків у світі як для країни базування, так і для країни перебування. Перелічено основні критерії економічного впливу транснаціональних банків. Зазначено основні тенденції розвитку транснаціональних банків в Україні та світі. Наведено пропозиції щодо забезпечення стабільного функціонування як транснаціональних банків, так і банківської системи в цілому.
СИСТЕМАТИЗАЦІЯ МЕТОДИК АНАЛІЗУ ІНВЕСТИЦІЙНОЇ ПРИВАБЛИВОСТІ ПІДПРИЄМСТВА
Authors: Найдовська Ангеліна , Андрієнко Ярина
Published: July 2023

Систематизовано підходи до оцінки інвестиційної привабливості підприємства, виділено підхід на основі оцінки фінансово-економічного стану підприємства, підхід на основі оцінки інвестиційних проєктів та на основі вартості підприємства. Наведено переваги та недоліки підходів. Детально розглянуто підхід, що базується на оцінці фінансово-економічного стану підприємства. Проаналізовано різні методи визначення інвестиційної привабливості підприємства на основі оцінки фінансово-економічного стану підприємства вітчизняними науковцями. Запропоновано здійснювати оцінку інвестиційної привабливості підприємства на основі розширеної системи показників ретроспективного характеру, що відбивають особливості роботи як самого підприємства (внутрішня складова), так і галузі, в якій воно функціонує (зовнішня складова).
ВПЛИВ ДИСТАНЦІЙНОЇ РОБОТИ НА ПСИХОЛОГІЧНИЙ СТАН ОСОБИСТОСТІ
Authors: Сова Тетяна , Циганчук Тетяна
Published: July 2023

Одним із найважливіших завдань нинішніх років є збереження фізичного та психічного здоров’я населення. У статті розкрито основі теоретико-методологічного аналізу проблеми, розглянуто поняття психічного стану особистості. Визначено складові психічного стану особистості. Досліджено види психічних станів. Здійснено емпіричне дослідження психічного стану особистості в умовах дистанційної роботи. Спираючись на отримані результати дослідження зроблений висновок, про те, що рівень психічних станів досліджених в основному має низькі та середні результати.
УКРАЇНСЬКЕ СЕЛЯНСТВО НА ПОЧАТКУ ХХ СТОЛІТТЯ
Authors: Бибік Кирило
Published: July 2023

Україна традиційно являла собою аграрний край, 80% населення якого на початку минулого століття складали селяни, а отже можна сказати що воля селян була відображенням прагнень усього українського народу. У 1917 році спалахує Українська революція, визначна подія в нашій історії і унікальний шанс українського народу вибороти власну державність на 70 років раніше. Шанс, який однак було втрачено. Однак чому український народ не лише не постав у єдиному пориві на захист української державності, а навпаки, більшість проявів державотворення сприймав явно вороже, в штики. Данна стаття демонструє становище селян України на зламі століть, наводить причини їх важкого матеріального становища, пояснює антагонізм села до міцних державницьких інститутів, висвітлює діяльність селянства в роки Російської революції, їх власне бачення справедливості, а також спроби імперії послабити протестну активність на селі, які призведуть лише до ще більшого загострення проблеми.
Práticas Integrativas e Complementares na Atenção Primária à Saúde em Município de Médio Porte
Authors: Santos Bruna Antonia Borba dos , Mombelli Monica Augusta , Vieira Rafaelly Gomes , Lopes Anália  Rosário
Published: July 2023

Introdução: as Práticas Integrativas e Complementares (PICS) foram institucionalizadas no sistema único de saúde por meio da Política Nacional de Práticas Integrativas e Complementares (PNPIC). São recursos terapêuticos que buscam não só a recuperação da saúde, mas também a prevenção de doenças, e têm ênfase na integração do ser humano com o meio ambiente e a sociedade. O objetivo deste estudo foi realizar o levantamento do uso das PICS pelos profissionais nos serviços da Atenção Primária à Saúde (APS) em um município de médio porte do estado do Paraná. Método: foi realizado um estudo descritivo com aplicação de questionário eletrônico no Google Forms com todos os profissionais da APS de todas as unidades de saúde da família do município. Resultados: participaram 242 profissionais, destes, 31 (12,81%) utilizam PICS em sua atuação na APS e 122 (50,41%) não conhecem as PICS. A PIC mais utilizada foi a Fitoterapia (44,11%), seguida da Auriculoterapia (17,64%) e da Osteopatia (11,76%). Os profissionais que mais utilizaram PICS foram os residentes do programa multiprofissional em saúde da família, os médicos e os agentes comunitários de saúde com 19,35% cada categoria. Somente 8,26% dos participantes relataram que receberam capacitação sobre o uso das PICS. Conclusão: foi possível observar que mesmo com a PNPIC aprovada desde 2006, a utilização das PICS na APS do município estudado ainda é modesta. Assim, vale propor maior investimento em capacitação, educação permanente e/ou outras estratégias para melhorar a compreensão sobre as PICS e seu uso na atenção primária à saúde.
Metode Pengajaran Berbasis Karakter Untuk Anak Usia Dini (Telaah Pemikiran Ratna Megawangi)
Authors: Dewi Ratna , Syukur Taufik Abdilllah , Abusiri Abusiri , Hendra Tomi
Published: July 2023

Abstrak, Metode penelitian ini adalah library research Tujuan penelitian ini adalah untuk mengetahui metode pengajaran karakter yang dikembangkan Ratna Megawangi untuk anak usia dini.. Penelitian ini berkesimpulan bahwa metode pembelajaran berbasis karakter yang dikembangkan oleh Ratna Megawangi pada anak usia dini adalah knowing the good, reasoning the good, feeling the good, acting the good, dan Developmentally Approriate Practices. Menurutnya, ada beberapa metode pengajaran di Taman kanak-kanak yang dapat menjadi perhatian bagi para pendidik, dalam perkembangan karakter anak, diantaranya: skema membaca, menulis dan berhitung (calistung), terpaut pada pemberian nilai dan raport, kritikan dan informasi hasil belajar yang cenderung negatif, kelas sunyi dan proses belajar satu arah, serta intens didalam kelas tanpa ice breaking dalam waktu yang lama.

Kata Kunci: Metode Pengajaran, Karakter, Anak Usia Dini, Ratna Megawangi.
The Advantages of Fuzzy Control for Heat Pumps Systems
Authors: Sánta Róbert , Simon János , Garbai László
Published: July 2023

Application of fuzzy control has been observed in various engineering fields due to its ability to handle uncertainties and non-linearities. In this study, the advantages of using fuzzy control in heat pump systems are being investigated. Specifically, the performance of a heat pump system with a conventional proportional-integral-derivative (PID) controller is being compared to that of a heat pump system with a fuzzy logic controller. It has been demonstrated by the results that the fuzzy control-based heat pump system offers better performance in terms of energy efficiency, temperature control, and overall system stability. This study contributes to the understanding of the potential benefits of fuzzy control-based heat pump systems and provides a foundation for further research in this area.
Agro-climatic Analysis for Agricultural Adaptation in Hungary
Authors: Biró Kinga , Kovács Erik
Published: July 2023

Both globally and in Hungary, agriculture is one of the industries that is most vulnerable to weather and climate extremes. Intense temperature rises, spatial and temporal variations in precipitation, and significant changes in extreme climatological and weather parameters have contributed to changes in the conditions of cropland, crop losses, and impacts on crop quality in recent years. This paper depicts the transformation of the domestic agricultural sector due to the extreme drought shock of 2022, as well exploring the adaptation strategies applied. The research is based on official agro-climate database and crop data, and the temperature, precipitation, and radiation during the growing season are all examined. The agro-meteorological properties in Hungary had to be investigated for the entire year and all four of its seasons, with indicator analysis projected onto the ever-increasing and dormant seasons. Long-term climate analysis is necessary to understand the historic drought of 2022 and the success of future adaptation and mitigation techniques. The results can help smallholders effectively reduce the adverse impacts of drought conditions, thereby increasing their adaptation to similar shocks.
Potensi Penggunaan Energi Ramah Lingkungan Pada Sistem Daya Gerak Alpalhankam dalam Mendukung Strategi Pertahanan Indonesia
Authors: Prasetiyo Riyan Eko , Coutsar Ardan Nagra , Aprilya Sonia , Tobing Michael , Endy Anugrah , Ansori
Published: July 2023

Perancangan alat peralatan pertahanan keamanan (alpalhankam) sebagai strategi pertahanan dan keamanan, akan menghadapi tantangan untuk mengurangi jejak karbon. Bahan bakar yang bersumber dari energi baru terbarukan menjadi rencana aksi di masa depan untuk mencapai tingkat efisiensi energi tinggi dan upaya untuk mencapai net zero emission di sektor pertahanan.  Penelitian ini bertujuan untuk memberikan masukan mengenai penggunaan teknologi ramah lingkungan di bidang alpalhankam   Dalam upaya mendukung strategi pertahanan Indonesia. Penelitian ini menggunakan metode studi literatur, wawancara, dan metode analisis SWOT (Strengths, Weaknesses, Opportunities, Threats). Berdasarkan hasil kajian, terdapat beberapa aplikasi pemanfaatan energi ramah lingkungan dalam aspek komersial yang terbatas pada bidang pertahanan dan keamanan, seperti biodiesel, bioavtur, dan penggunaan baterai. Penggunaan energi ini berpotensi untuk diterapkan pada alpalhankam, dengan mempertimbangkan solusi dari permasalahan yang timbul. Berdasarkan jangkauan misi operasi dan kehandalannya, aplikasi tersebut dapat digunakan sebagai energi pada operasi militer selain perang atau non-kombatan, karena tidak beroperasi dalam jangkauan operasi dalam menghadapi tantangan yang berat dalam penggunaan energi yang tinggi.
Análise da COVID-19 como fator predisponente para pancreatite aguda: uma revisão integrativa da literatura
Authors: Azevedo Juliana Fabricio de , Fonseca Davila Fernanda Rodrigues , Rasera Junior Irineu
Published: July 2023

Objetivos: Este estudo tem como objetivo principal analisar os mecanismos fisiopatológicos presentes em pacientes com COVID-19 que desenvolveram pancreatite aguda. Secundariamente, busca-se avaliar seu quadro clínico e entender a epidemiologia atual desta patologia em um cenário pós COVID-19. Métodos: Este estudo é uma revisão de literatura do tipo integrativa, em que foram utilizadas as palavras-chave “pancreatite aguda” e “COVID-19”, suas variantes e combinações em inglês nas bases de dados PubMed e SciELO. Como critérios de inclusão, foram selecionados estudos do tipo ensaio clínico randomizado, caso controle, coorte e estudos transversais. Foram selecionadas pesquisas com pacientes de todas as idades, com período de publicação a partir de 2020 e nas línguas português, inglês e espanhol. Resultados: Foram selecionados 9 artigos para essa revisão integrativa, sendo 44% do tipo estudo transversal (n = 4) e 66%, do tipo coorte (n = 5). Discussão: Acredita-se que o dano pancreático ocorre paralelamente à gravidade da doença em pacientes com COVID-19. Isso pode ocorrer devido a mecanismos do próprio vírus, da resposta do hospedeiro ou de medicamentos usados no tratamento da COVID-19. Ainda, a maioria dos pacientes apresenta-se com quadro clínico grave e exames laboratoriais alterados. Conclusão: Os pacientes dos artigos analisados apresentaram achados laboratoriais compatíveis com o quadro de pancreatite aguda, além de quadro clínico característico e evolução variável. É preciso que sejam feitos mais estudos primários com populações maiores e mais homogêneas para entendermos como a relação entre as duas doenças, de fato, ocorrem.
Qualidade do sono em idosos com dor crônica: uma revisão integrativa
Authors: Santana Caroline Alvarenga de Assis , Peron Carballo Fábio
Published: July 2023

O processo de envelhecimento implica no surgimento de inúmeros fatores de risco para alterações no sono como a dor crônica. Dessa forma, objetivo deste estudo foi revisar a literatura sobre os temas dor crônica e qualidade do sono em relação aos idosos, reportando as associações entre essas duas variáveis. Os materiais de pesquisa foram obtidos nas bases de dados MEDLINE, LILACS e SCIELO, utilizando-se das palavras-chave dor crônica, idoso e sono. As buscas eletrônicas obtiveram como resultado 111estudos, sendo 73 na base de dados MEDLINE, 36 na base de dados SCIELO e 02 na base de dados LILACS. Um total de 04 estudos atendeu aos critérios de elegibilidade e foram incluídos na presente revisão. Os dados obtidos sugerem que a dor crônica é comum entre idosos e está associada à quadros de depressão, bem como à má qualidade de vida e à má qualidade de sono. Foi possível constatar que os resultados desta análise corroboram com a literatura, ainda escassa de estudos com essa população, mostrando a necessidade de mais pesquisas nesta área.
Refletindo sobre ser professor na rede pública de ensino brasileira
Authors: Rossi Mayara , Silva Adriana da , Silva Edson Garcia da , Sousa Elenice Ribeiro de , Sobrinho Elizimari de Queiroz , Oliveira Sandra Regina Medeiros , Silva Janaina Patricia de Souza e , Marcelino Juliana Aparecida Reis , Freitas Juliana Marta Damiani de , Zorze Lidiane Magalhães da Silva , Vidarte Luciana Raquel Cezar , Santos Renata das Dores Silva dos , Silva Rosana Magalhães da , Verdelho Sônia Aparecida Araújo , Mendes Tamires Arrais , Passos Tatiane Carneiro Cardoso dos , Oliveira Vanusa Maria de
Published: July 2023

O estudo teve por objetivo analisar o “ser professor na atualidade”, mapeando os desafios da profissão, e apresentando uma reflexão contemporânea e histórica sobre a prática docente na Educação Pública brasileira. A pesquisa se estrutura metodologicamente como bibliográfica narrativa de abordagem qualitativa. A coleta de dados se deu por meio da plataforma de busca “Google Acadêmico”, onde se utilizou os descritores “Professor da atualidade” e “Professor and Educação Básica”. As buscas e a escrita do referido artigo se deram nos meses de janeiro a julho de 2021. A análise dos resultados seguiu os pressupostos da Análise de Conteúdo. Os resultados evidenciam que ser profissional do ensino, na sociedade contemporânea, não é tarefa fácil visto que existem muitos fatores que influenciam no exercício profissional docente, desde sua formação até constituição profissional. No Brasil a partir da década de 1990, proliferam os estudos e pesquisas sobre a subjetividade e o imaginário social. Esses estudos enfocam a figura do professor como centro do processo identificador da profissão docente, desvelando os mitos, crenças e representações que cercam o fazer pedagógico na sala de aula. Durante o mapeamento da pesquisa nota-se que há vários estudos sobre a formação do docente, tendo como ponto de partida as características pessoais e o percurso de vida profissional do professor.
Adolescent victims of sexual abuse and music therapy: A systematic review
Authors: Suzuki Denise Chrysostomo , Monge Aline Bitencourt , Silva Barbara Soares da , Viana Janayna Araújo , Suzuki Paulo Roberto , Annunciato Neto Rafael , Vitalle Maria Sylvia de Souza
Published: July 2023

Background: Sexual violence represents a major public health issue that impacts the future of adolescents. Several studies have examined music therapy as treatment option by suggesting multiples ways on dealing with music experiences. However, not much information in literature is known in professional practice. The current research contributes in understanding use of music as a therapy with adolescent’s victims of sexual abuse. Objective: Identify primary research about music therapy towards adolescents’ victims of sexual abuse to understand context of care, participants’ age, length of therapy, therapist training, clinical goals, methods applied, potentials and issues related to adolescent period of life. Participants and setting: Adolescent, who suffered from sexual abuse in childhood and / or adolescence attending public or private health service. Methods: Qualitative systematic review, seven databases and three specific journals were qualitative systematically searched, as well as been identified primary studies screened against inclusion criteria. Results: Among 492 findings, seven studies between the years 1992 and 2018 were included. Music therapy methodology has been offered in hospitals, private offices, institutions, [of short, medium and long term], by a qualified music therapist; several symptoms were addressed like depression, post-traumatic stress disorder, anxiety with goals to improve social skills; positive affective experiences; emotional self-regulation; autobiographical narrative; expression and communication of ideas and feelings with a variety of methods. Conclusions: Music therapy seems to be an important therapeutic method/tool for young patients who feel comfortable upon music, it facilitates therapeutic bond, helps expression of feelings and is less confrontational therapy.
O herbicida glifosato pode interferir nas interações sociais de abelhas Apis mellifera operárias?
Authors: Antunes Bianca Caroline , Ribeiro Letícia Gonçalves , Roque Amanda Maria , Ferreira Kátila Maria , Winkaler Elissandra Ulbricht , Lhano Marcos Gonçalves
Published: July 2023

O objetivo deste estudo foi observar possíveis alterações comportamentais de abelhas africanizadas (Apis mellifera Linnaeus, 1758), após exposição ao herbicida glifosato. Para isso, foram utilizados dois métodos de exposição (ingestão e pulverização) e as concentrações de 0 (Grupo Controle), 0,01 e 1 mL.L-1, durante 24 horas de exposição. No método de ingestão, as abelhas foram alimentadas com mel acrescido das soluções, enquanto no teste de contato, as abelhas foram pulverizadas com as concentrações do herbicida. Analisou-se as interações de contato (antenação e trofalaxia), mobilidade (capacidade de alçar voo) e letargia (dificuldade de alçar voo e voo deficiente), além da mortalidade dos indivíduos. De forma geral, nos dois tipos de exposição (ingestão e pulverização) com a menor concentração testada (0,01 mL.L-1) foram observadas maior frequência de contato e menor mobilidade das abelhas. Enquanto que, as abelhas expostas a 1 mL.L-1 de glifosato apresentaram menor contato e maior mobilidade e letargia, além de maior taxa de mortalidade das abelhas. Confirmou-se que maiores concentrações do herbicida podem afetar as interações sociais das abelhas; contudo, o método de pulverização foi o que acarretou maior mortalidade. Assim, concluímos que a exposição ao glifosato ocasiona efeitos nas interações sociais em indivíduos de A. mellifera.
Toxina botulínica tipo A na harmonização orofacial
Authors: Campos Caroline Cristina Siviero , Suguihara Roberto Teruo , Muknicka Daniella Pilon
Published: July 2023

A toxina botulínica (TXB) é uma neurotoxina que tem sido utilizada terapeuticamente desde a década de 1970 para inibir a liberação de acetilcolina (ACH) nos músculos esqueléticos. O tipo A da TXB tem sido amplamente empregado na harmonização orofacial (HOF) e em procedimentos estéticos, como o tratamento de rugas e linhas faciais, além de apresentar aplicações funcionais no combate a enxaquecas, espasmos musculares e hiperidrose. Sua ação ocorre através da clivagem de proteínas relacionadas ao transporte e liberação de neurotransmissores, interrompendo a transmissão neural sináptica em músculos e estruturas inervadas. No âmbito estético, ela é indicada para tratar rugas, pés de galinha, sulcos nasolabiais e sorriso gengival, enquanto no contexto funcional abrange enxaquecas, espasmos musculares, bruxismo e hiperidrose. Contudo, seu uso prolongado pode resultar em complicações, como atrofia muscular e hipertrofia compensatória em músculos adjacentes. A TXB atua inibindo a liberação de ACH, o que leva ao relaxamento muscular localizado e suavização da pele sobrejacente. Sua farmacologia, particularmente a estrutura composta por cadeia pesada e cadeia leve, interfere nos receptores nos terminais nervosos, bloqueando a fusão das vesículas sinápticas e a liberação de neurotransmissores. Apesar de sua eficácia, seu uso requer cautela devido às possíveis complicações associadas. Para tanto, o objetivo dessa pesquisa é, através de uma revisão narrativa da literatura analisar o uso e mecanismo de ação da TXB, com foco na sua aplicação na HOF.
ANTIANGIOGENIC ACTIVITY AND ROS-MEDIATED LUNG CANCER CELL LINE INJURY OF ZERUMBONE
Authors: ABBAS ALBAAYİT Shaymaa Fadhel , MOHAMMED Maryam Kamel
Published: July 2023

Objective: Zerumbone (ZER) is a well-known natural compound that has been reported to have anti-cancer effect. Thus, this study investigated the ZER potential to inhibit Thymidine Phosphorylase (TP) and the ability to trigger Reactive oxygen species (ROS)-mediated cytotoxicity in non-small cell lung cancer, NCI-H460, cell line.
Material and Method: The antiangiogenic activity for ZER was evaluated by using the thymidine phosphorylase inhibitory test. Reactive oxygen species (ROS) production was determined via DCFDA dye by using flow cytometry.
Result and Discussion: ZER was found to be potent TP inhibitory with the IC50 value of 50.3± 0.31 μg/ml or 230±1.42 µM. NCI-H460 cells upon treatment with ZER produced significant ROS by 55.7%. Consequently, ZER exerts anti-angiogenic properties and modulates ROS production in lung cancer cells, serving as leads for better therapeutic index in cancer drug.
Belediyelerin Kentsel Dirençlilik Algısını Stratejik Planlardan Okumak: TR71 Bölgesi Örneği
Authors: KAYA Hasan , YAYLI Hasan
Published: July 2023

Kentler, bütün dünyada sayısı her geçen gün artan kalabalık nüfuslara ev sahipliği yapmakta ve insan hayatının sürdürülebilmesi hususunda vazgeçilmez unsurlardan biri olmaya devam etmektedir. Bunun yanında kentleri; iklim değişikliği, doğal afetler ve çevre sorunları gibi küresel ve bölgesel ölçekte tehdit eden unsurların sayısında da artış gözlenmektedir. Bu durum kentlerin bu tarz tehlikelere karşı hazırlıklı, mücadeleci ve uyum sağlayabilen nitelikler kazanmasını da zorunlu kılmaktadır. Çalışmamızda, bir kentsel yönetim birimi olan belediyelerin kentsel dirençlilik algısını tespit etmek amacıyla, temel hedeflerini belirttikleri stratejik planlarında kentsel dirençliliği konu edinen amaç ve hedeflerine yönelik saptamalar yapılacak ve bu sayede kentsel dirençlilik ile ilgili belediyelerin farkındalık düzeyleri ve faaliyet düzeyleri çok yönlü olarak ortaya konmaya çalışılacaktır. Stratejik planlar üzerinde söz konusu analizler yapılırken OECD, Birleşmiş Milletler ve Dünya Bankası gibi uluslararası kuruluşların kentsel dirençlilik ile ilgili benimsediği yaklaşımlara dair hususlar referans alınacaktır. İlgili belediyeler ise “Türkiye İstatistiki Bölge Birimleri Sınıflandırması” (İBBS) baz alınarak seçilmiştir. Bu sınıflandırmaya göre TR71 bölgesini teşkil eden Aksaray, Kırşehir, Kırıkkale, Nevşehir ve Niğde belediyeleri çalışmamıza konu olmuştur. Çalışmamızda, söz konusu belediyelerin stratejik planlarında belirtilen amaç ve hedeflerinin analiz edilmesiyle, kentsel dirençlilik ile ilgili farkındalık düzeyleri ve öngördükleri eylem planları tespit edilerek çeşitli çıkarımlarda ve önerilerde bulunulacaktır.
A Review of Leadership Research: A Comparative and Systematic Review
Authors: TEPE Nagihan
Published: July 2023

This research is a comparative and systematic review of doctoral dissertations on leadership in the fields of educational administration and business administration in Turkey. Doctoral theses are preferred because they are prepared with a higher level of knowledge, skills and academic competence than master's theses and examine the subject they deal with in a broader and more detailed manner. The main purpose of this review is to reveal the similarities and differences of leadership studies in both fields, to see and present how they are handled under various headings from a broad perspective. Within the framework of this main purpose, the comparative distribution of doctoral dissertations in the fields of "educational administration" and "business administration" according to years, disciplines, research method and sample group, whose leadership characteristics were examined as the study group, which types of leadership were addressed and which other organizational variables were investigated together with the subject of leadership were examined. Although the fields of educational administration and business administration differ from each other scientifically, when the studies abaout leadership are examined, it is seen that the subject is handled with similar methods within the framework of similar purposes, although some differences are detected.
Hazar Denizi'nden Akdeniz'e Zengezur Koridoru
Authors: MEMMEDOV Asim , HASANOĞLU Murteza
Published: July 2023

27 Eylül 2020’de başlayan Azerbaycan – Ermenistan Savaşı’nın 10 Kasım’da Azerbaycan’ın kesin zaferi ile sonuçlanması ve otuz yıl süren Ermeni işgalinin son bulması, sadece Azerbaycan için değil, Güney Kafkasya bölgesi, Rusya, Türkiye, Irak, Suriye, İsrail’e kadar uzanan geniş bir coğrafyada yeni fırsatlar ve işbirliği olanakları doğurmuştur. Her ne kadar Ermenistan, savaştan kesin yenilgiyle çıktığını kabul eden ateşkes anlaşmasını imzalasa da, arkasına yaslandığı güçlerin desteğine güvenerek halen anlaşmanın hükümlerinden doğan yükümlülüklerini yerine getirmemektedir. Zengezur Koridoru Azerbaycan – Nahçıvan ulaşım hatlarının açılmasına ve garanti altına alınmasına neden olacağı kadar, bölgesel ve küresel ölçekte ulaşım ağının gelişmesi için de büyük olanaklar sağlayacaktır. Bakü – Tiflis – Kars demiryolu Azerbaycan’la Türkiye’nin Doğu, Karadeniz, İç Anadolu ve Marmara bölgelerini birbirine bağladığı halde, Zengezur Koridoru Azerbaycan`ı ve zerbaycan’ın bir parçası olan Nahçıvan’ı Türkiye’nin Güney Doğu ve Akdeniz bölgelerine bağlayabilir. Zengezur Koridoru Güneydoğu Anadolu’da çekilecek yeni demiryolu hattı aracılığıyla sadece Türkiye ve Azerbaycan için değil, Ermenistan’ın yanı sıra, Akdeniz’e kıyısı bulunan Suriye, Ürdün, İsrail, hatta Irak gibi devletlerin de demiryolu ulaşım ağına entegre olmalarına neden olabilecektir. Zengezur Koridoru aracılığı ile Azerbaycan’ın demiryolu ağı, Güney Doğu anadolu’da inşa edilecek yeni demiryolu hattının bir kolu ilerde İskenderun üzerinden Süriye ve İsrail`e kadar uzanan geniş bir coğrafyayı kapsayacak ve Asya-Orta Doğu, Rusya-Orta Doğu, Azerbaycan-İsrail ticaret ilişkilerinin gelişmesine, taşımacılık maliyetlerinin düşmesine ve geniş bir coğrafyada ulaşım ağlarının etnegresine neden olacaktır.
Therapeutic potential of extracellular vesicles derived from cardiac progenitor cells in rodent models of chemotherapy-induced cardiomyopathy
Authors: Desgres Manon , Lima Correa Bruna , Petrusca Lorena , Autret Gwennhael , Pezzana Chloé , Marigny Céline , Guillas Chloé , Bellamy Valérie , Vilar José , Perier Marie-Cécile , Dingli Florent , Loew Damarys , Humbert Camille , Larghero Jérôme , Churlaud Guillaume , Renault Nisa , Croisille Pierre , Hagège Albert , Silvestre Jean-Sébastien , Menasché Philippe
Published: July 2023

Background

Current treatments of chemotherapy-induced cardiomyopathy (CCM) are of limited efficacy. We assessed whether repeated intravenous injections of human extracellular vesicles from cardiac progenitor cells (EV-CPC) could represent a new therapeutic option and whether EV manufacturing according to a Good Manufacturing Practices (GMP)-compatible process did not impair their bioactivity.

Methods

Immuno-competent mice received intra-peritoneal injections (IP) of doxorubicin (DOX) (4 mg/kg each; cumulative dose: 12 mg/kg) and were then intravenously (IV) injected three times with EV-CPC (total dose: 30 billion). Cardiac function was assessed 9–11 weeks later by cardiac magnetic resonance imaging (CMR) using strain as the primary end point. Then, immuno-competent rats received 5 IP injections of DOX (3 mg/kg each; cumulative dose 15 mg/kg) followed by 3 equal IV injections of GMP-EV (total dose: 100 billion). Cardiac function was assessed by two dimensional-echocardiography.

Results

In the chronic mouse model of CCM, DOX + placebo-injected hearts incurred a significant decline in basal (global, epi- and endocardial) circumferential strain compared with sham DOX-untreated mice (p = 0.043, p = 0.042, p = 0.048 respectively) while EV-CPC preserved these indices. Global longitudinal strain followed a similar pattern. In the rat model, IV injections of GMP-EV also preserved left ventricular end-systolic and end-diastolic volumes compared with untreated controls.

Conclusions

Intravenously-injected extracellular vesicles derived from CPC have cardio-protective effects which may make them an attractive user-friendly option for the treatment of CCM.
Writing-to-learn in biology and mathematics teacher education: promoting students’ topic knowledge and insight
Authors: Van Dijk Aartje , Van Gelderen Amos , Kuiken Folkert
Published: July 2023

In the present study, effects of Genre Writing instruction added with planning and revising activities (GWPR) are investigated in teacher education. This type of instruction was considered promising because it appeared to lead to positive effects on topic knowledge and insight in previous studies conducted in secondary education. Researchers’ expectation was that writing-to-learn activities by means of GWPR support teacher candidates in acquiring topic knowledge and insight into subject matter. Two studies were undertaken, one in biology and one in mathematics teacher education, each comprising a quasi-experiment and a think-aloud study. Both studies were embedded in regular courses. Researchers co-created writing-to-learn tasks with the teacher educators involved. Both experiments showed positive effects on learning. Results of the think-aloud studies provided evidence for specific indicators (students’ reflections) of the process of writing-to-learn, in which experimental teacher candidates differed from the control group. Finally, we discuss the impact of the results for the theory, follow-up studies and teaching practice.
Efficacy and safety of high-dose intramuscular vitamin D2 injection in type 2 diabetes mellitus with distal symmetric polyneuropathy combined with vitamin D insufficiency: study protocol for a multicenter, randomized, double-blinded, and placebo-controlled trial
Authors: Chen Tao , Xing Xiaoyan , Huang Lihua , Tu Mei , Lai Xiaoli , Wen Shidi , Cai Jin , Lin Shenglong , Zheng Youping , Lin Yuehui , Xu Lijuan , Qiu Yuwen , Qiu Lumin , Xu Yuebo , Wu Peiwen
Published: July 2023

Background

Distal symmetric polyneuropathy (DSPN) is the most common chronic complication of type 2 diabetes mellitus (T2DM). DSPN may lead to more serious complications, such as diabetic foot ulcer, amputation, and reduced life expectancy. Observational studies have suggested that vitamin D deficiency may be associated with the development of DSPN in T2DM. However, interventional studies have found that low-dose vitamin D supplementation does not significantly improve neuropathy in DSPN. This study aims to evaluate the efficacy and safety of intramuscular injection of high-dose vitamin D (HDVD) in T2DM with DSPN combined with vitamin D insufficiency.

Methods and analysis

We will conduct a multicenter, randomized, double-blinded, and placebo-controlled trial in four large hospitals. All eligible participants will be randomly assigned to either the vitamin D2 supplement or placebo control group and injected intramuscularly monthly for 3 months. Additionally, anthropometric measurements and clinical data will be collected at baseline and 3 months. Adverse events will be collected at 1, 2, and 3 months. The primary outcome measure is the change in the mean Michigan Neuropathy Screening Instrument (MNSI) score at baseline and 3 months post-intervention. We will use the gold-standard liquid chromatography-tandem mass spectrometry method to distinguish between 25(OH)D2 and 25(OH)D3 levels. The MNSN score before the intervention will be used as a covariate to compare the changes between both groups before and after the intervention, and the analysis of covariance will be used to analyze the change in the MNSI score after HDVD supplementation.

Discussion

Glycemic control alone does not prevent the progression of DSPN in T2DM. Some studies have suggested that vitamin D may improve DSPN; however, the exact dose, method, and duration of vitamin D supplementation are unknown. Additionally, neuropathy repair requires HDVD supplementation to sustain adequate vitamin D levels. This once-a-month intramuscular method avoids daily medication; therefore, compliance is high. This study will be the first randomized controlled trial in China to analyze the efficacy and safety of HDVD supplementation for patients with T2DM and DSPN and will provide new ideas for pharmacological research and clinical treatment of diabetic neuropathy.

Clinical trial registration

https://www.chictr.org.cn/, identifier ChiCTR2200062266.
Stackelberg equilibrium-based energy management strategy for regional integrated electricity–hydrogen market
Authors: Wang Qinghan , Wang Yanbo , Chen Zhe
Published: July 2023

This paper develops an optimal energy bidding mechanism for the regional integrated electricity–hydrogen system (RIEHS) considering complex electricity–hydrogen energy flow and further presents an electricity–hydrogen optimization management strategy based on Stackelberg game. The transaction mode of the RIEHS is first introduced, and the optimization models for the three market game participants are established. Then, the Stackelberg game-based bidding mechanism is formulated, where the electricity–hydrogen operator (EHO) is the leader and the regional electricity–hydrogen prosumer (REHP) and load aggregator (LA) are the followers. The EHO dominates the game through energy bidding, and REHP and LA respond to the bidding decision. The Stackelberg equilibrium of the formulation is obtained by applying the differential evolutionary algorithm combined with quadratic programming (DEA-QP). Finally, a demonstration case is studied to analyze the market behavior of the three market players and further validate the effectiveness of the proposed strategy. The proposed strategy is able to produce additional economic benefits to REHP and LA and improve the utilization of hydrogen.
Impact of land use and illegal human activities on the spatio-temporal distribution of Loxodonta africana (Cuvier, 1825) during the dry season in Arly National Park in Burkina Faso
Authors: Sawadogo Emmanuel , Sandwidi Harouna , Hema Emmanuel M.
Published: July 2023

This study aimed to determine the impact of land use and illegal activities on elephant distributions in 2003, 2015, and 2021. Geospatial data inclusion satellite images of different characteristics were used as well as aerial count of animals along linear transects of varying widths. Using ArcMap 10.8, we laid grilles of 100 km2 covering the entire study area. We performed clipping to display and estimate the area of elephant’s occupancy in each grid. As such, we were able to determine the number of elephants and the number of illegal activities in each grid. Correlation analysis were performed to understand relationships between elephants’ number and land-use units as well as the illegal activities. The identified different land use units were: rainfed crop, gallery forest, Wooded savanna, shrubby savanna, grass savanna, and water surface. Of the variables studied, only annual crop, gallery forest, shrubby savanna and illegal activities were significantly correlated with elephant numbers. Annual crop and illegal activities were negatively correlated with elephant numbers, while gallery forest and shrubby savanna were positively correlated with elephant abundance. These results confirmed that water, forage and serenity are the main factors that explain the distribution of elephant in protected areas.
Variability in soil redox response to seasonal flooding in a vernal pond
Authors: Barczok Maximilian , Smith Chelsea , Di Domenico Nicolle , Kinsman-Costello Lauren , Herndon Elizabeth
Published: July 2023

Vernal ponds are ephemeral landscape features that experience intermittent flooding and drying, leading to variable saturation in underlying soils. Redox potential (Eh) is an important indicator of biogeochemical processes that changes in response to these hydrological shifts; however, high-resolution measurements of Eh in variably inundated environments remain sparse. In this study, the responses of soil Eh to ponding, drying, and rewetting of a vernal pond were investigated over a 5-month period from late spring through early autumn. Soil Eh was measured at 10-min frequencies and at multiple soil depths (2–48 cm below the soil surface) in shallow and deep sections within the seasonally ponded lowland and in unsaturated soils of the surrounding upland. Over the study period, average Eh in surface soils (0–8 cm) was oxidizing in the upland (753 ± 79 mV) but relatively reducing in the shallow lowland (369 ± 49 mV) and deep lowland (198 ± 37 mV). Reducing conditions (Eh <300 mV) in surface soils prevailed for up to 6 days in the shallow lowland and up to 24 days in the deep lowland after surface water dried out. Intermittent reflooding resulted in multiple shifts between reducing and oxidizing conditions in the shallow lowland while the deep lowland remained reducing following reflooding. Soil Eh in the uplands was consistently oxidizing over the study period with transient increases in response to rain events. Reducing conditions in the lowland resulted in greater Fe-oxide dissolution and release of dissolved Fe and P into porewater than in the surrounding uplands. We determined that change in water depth alone was not a good indicator of soil Eh, and additional factors such as soil saturation and clay composition should be considered when predicting how Eh responds to surface flooding and drying. These findings highlight the spatial and temporal variability of Eh within ponds and have implications for how soil processes and ecosystem function are impacted by shifts in hydrology at terrestrial-aquatic interfaces.