bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Soaking Java barb (Baryoniums gonionotus) Eggs in Jatropha Leaf Solution (Jatropha curcas L.) on Their Hatching and Survival Rate
Authors: Rusda Yusrotul , Prayitno Slamet Budi , Hastuti Sri
Published: December 2023

The biggest problem that often found in barb hatcheries are the poor hatching rate of eggs. One of the causes of low hatchability is infestation of fungi such as Saprolegnia sp. Prevention of the infestation of fungi could be done by adding natural ingredients such as plants leaves that contain antifungal, such as Jatropha leaf. Soaking Jatropha leaf solution aims to protect the chorion from being infestated by fungi so that it can minimize hatching failure of eggs. The purpose of this study was to determine the effect of soaking Jatropha (Jatropha curcas L.) leaf solution on the hatching rate and survival rate of Java barb (Barbonymus gonionotus) eggs. The testing eggs which were used on this study were originated from male and female broodstock aged 1-1.5 years. Experimental method was carried out using a completely randomized design (CRD) consisting of 4 treatments and 5 replications. The treatments were Jatropha leaf solution at dosages of A (0 g/l), B (2 g/l), C (4 g/l), and D (6 g/l). The data observed were embryonic development, hatching rate (HR), survival rate (SR), and water quality. The results showed that treatments C and D demonstrated fastest embryonic development and hatching phase achieved at 475 minutes. Furthermore, treatment C showed the best value with HR (84.00±3.16%), SR (85.24±1.00%). It can be concluded that soaking eggs using Jatropha leaf solution at concentration of 4 g/L significantly improved hatching rate and survival rate of Java barb (Barbonymus gonionotus). Keywords: Jatropha, Java barb eggs, hatchability, fungi
Implementation of the Inquiry Model on the Critical Thinking Ability of Prospective Physical Education Teachers in Football Learning
Authors: Hadiana Oman , Syamaun Muzakkir , Ratnawati Ratnawati
Published: December 2023

Physical education is not just about learning skills from several basic techniques in sports including football. Currently, football needs to be supported by critical thinking skills to produce a more focused and efficient game. The aim of this research is to implement an inquiry learning model on students critical thinking skills in the game of football in the aspects of maintaining possession of the ball, creating space in attack, and shooting the ball into the goal. The method used was an experiment with The Randomized Posttest Only Control Group Design. The total sample was 70 students divided into two groups, namely the experimental group of 35 people who were given inquiry model treatment and the control group of 35 people who were given conventional model treatment. The instrument for measuring critical thinking skills uses an observation sheet whose level of validity has been tested. The results of the research show that students critical thinking abilities for the inquiry model in football learning in the aspect of maintaining possession of the ball are in the very good category, while for the conventional model in this aspect they are in the good category. Students critical thinking skills for the inquiry model for the aspect of creating space in attack are in the very good category, while for the conventional model in this aspect they are in the good category. Students critical thinking skills for the inquiry model in the aspect of shooting the ball into the goal are in the very good category, while for the conventional model in this aspect they are in the good category. The application of the inquiry model for students as prospective physical education teachers in order to improve critical thinking skills in football game material has a significant impact.
IMPLEMENTASI PROGRAM ASURANSI USAHA TANI PADI DI DESA PLIKEN DAN DESA SANGGREMAN KABUPATEN BANYUMAS
Authors: Rokhman Kholil
Published: December 2023

Tujuan penelitian ini untuk mengetahui bagaimana implementasi program Asuransi Usaha Tani Padi di Desa Pliken Kecamatan Kembaran Kabupaten Banyumas dan Desa Sanggreman Kecamatan Rawalo Kabupaten Banyumas tahun 2019-2021. Penelitian ini menggunakan metode penelitian kualitatif dengan metode pengumpulan data melalui wawancara, observasi, dan dokumentasi. Informan yang dipilih adalah mereka yang mengetahui implementasi program Asuransi Usaha Tani Padi di dua desa tersebut. Hasil penelitian menjelaskan bahwa implementasi program tidak maksimal karena beberapa aspek yang mempengaruhi. Aspek tersebut seperti diadaptasi dari teori implementasi Thomas B Smith yakni implementing organization, target group, dan environmental factors. Implementing organization kurang personel, sebagian target group tak memiliki kemauan dan kesadaran, lingkungan sosial dan pertanian berpengaruh pada kurang maksimalnya implementasi Asuransi Usaha Tani Padi. Sementara faktor politik kebijakan berpengaruh pada implementasi tapi tak signifikan.
IMPLEMENTASI KEBIJAKAN PENANGANAN STUNTING DI DESA TAMANSARI KECAMATAN JATINEGARA KABUPATEN TEGAL
Authors: Nugroho Hari
Published: December 2023

Handling stunting is part of the human resource development strategy to produce a superior generation. These efforts include specific nutrition interventions and sensitive nutrition, which in their implementation require support from all parties, including the village government. Handling stunting in this village is inseparable from how the policy is implemented. The purpose of this study is to analyze the implementation of stunting management policies in Tamansari Village, Kecamatan Jatinegara, Kabupaten Tegal and determine the supporting and inhibiting factors.

The results of the study shows that the stunting management policy in Tamansari Village is still in progress. This means that problems related to coordination, funding and participation from village government officials and other relevant stakeholders are still the main problems. The Desa Tamansari Government has only accommodated the policy for handling stunting toddler in the APBDes after the issuance of the Decree of the Tamansari Village Head Number 5 of 2022 concerning the Establishment of the Tamansari Village stunting acceleration team (TPPS). Specific nutrition interventions for health programs for the target group of pregnant women, breastfeeding mothers, newborns, and infants under the age of two have basically been implemented for a long time through posyandu activities coordinated by village midwives, posyandu cadres, and family planning extension cadres. However, these activities are not in the context of handling stunting toddlers, but regular health service activities with the Health Office as the leading sector. In sensitive nutrition interventions, there is no intensive coordination between the village government and the social environment. Supporting factors for the handling of stunting in Tamansari Village include the support of the village government, the economic level of the target group not including poor families, so that the nutritional intake needs of children and mothers can actually be fulfilled independently and good social environmental conditions strengthen community participation in sensitive nutrition interventions and nutrition interventions. specifically in the management of stunting. The main inhibiting factor lies in the lack of communication and knowledge from the village government and residents regarding stunting and the impact of stunting, followed by inadequate budget support for handling stunting toddlers.
Gender Effect in Leader-Member Exchange A study on healthcare Sector
Authors: DEBNATH MUNSHI JAYEETA
Published: December 2023

Subordinates and leaders engage in a reciprocal relationship known as Leader-Member Exchange (LMX). However, while attempting to study the link and influence of gender on LMX, previous research yields inconclusive data. While several studies found a direct or indirect relationship, others did not link gender to LMX. These researchers inspired one another to begin the current investigation. Finding out how gender affected the quality of interactions between leaders and members was the aim of this study. The study was conducted in carefully chosen workgroups under the direction of supervisors, who were divided based on gender. (Males overseeing men, men overseeing women, women overseeing women, and women overseeing women). There is a noticeable change in the way Dyad members communicate when work groups are divided based on gender. The research also uncovered some noteworthy information concerning the impact of the demographic factor of gender on LMX.
Value of Low-dose CT and Ultralow-Dose CT Protocols in Clinical Practice: A Narrative Review
Authors: Siriwardana Shirom Rajeev
Published: December 2023

Computed tomography (CT) is a widely employed imaging modality with diverse clinical applications in pediatric and adult populations, offering numerous advantages. Despite several alternatives to imaging modalities with ionising radiation, CT scans have demonstrated persistent global popularity, contributing to a substantial amount of effective radiation doses for patients. This exposure results in hazards, including stochastic effects that amplify the radiation-induced cancer risk proportionally to the radiation dose received. CT-related radiation comprises a substantial portion of cumulative effective doses within diagnostic radiology, specifically impacting younger patient cohorts undergoing repeated investigations for chronic diseases over time. Scientific literature over recent decades has explored various methods to mitigate radiation doses during medical imaging. One notable strategy involves implementing low-dose and ultralow-dose CT protocols, maintaining diagnostic efficacy in acute and non-acute medical and surgical conditions. Utilising innovative image reconstruction algorithms, such as iterative reconstruction and emerging deep-learning algorithms based on artificial intelligence, plays a pivotal role in achieving an approximately 80% reduction in patient radiation compared to standard doses. This review article discusses the significance of low-dose protocols across a spectrum of acute and chronic medical conditions affecting different body systems.
The Gap between Coverage and Components of Postnatal Care and Factors Associated with Quality Postnatal Care among Home and Facility Births in Bangladesh
Authors: Priyanka Sabrina Sharmin , Dasgupta Dibbya Pravas , Abdullah Abu Yousuf Md , Ali Nazia Binte , Khatun Hafeza , Billah Sk Masum
Published: December 2023

Abstract: Background: Bangladesh has achieved remarkable progress in reducing maternal mortality, yet postpartum deaths remain a significant issue. Emphasis on quality postnatal care (qPNC) is crucial, as increased coverage alone has not sufficiently reduced maternal morbidity and mortality. Methods: This study included data from the Bangladesh Maternal Mortality Survey of 32,106 mothers who delivered within three years prior to the survey. Descriptive statistics were used to report coverage and components of postnatal care stratified by covariates. Log-linear regression models were used to assess the determinants of quality postnatal care among facility and home births. Results: From 2010 to 2016, postnatal care coverage within 48 hours of delivery by a qualified provider rose from 23% to 47%. 94% of facility births received timely PNC, contrasted with only 6% for home births. Despite the increased coverage, quality of care remained as low as 1% for home births and 13% for facility births. Key factors affecting qPNC utilization included socio-demographic factors, pregnancy complications, delivery method, financial readiness, and mobile ownership. Conclusion: Importantly, deliveries assisted by skilled birth attendants correlated with higher quality postnatal care. The study reveals a significant gap between the coverage and quality of postnatal care in rural Bangladesh, especially for home births. It underscores the need for targeted interventions to enhance qPNC.
Production systems with parallel heterogeneous servers of limited capacity: accurate modeling and performance analysis
Authors: Calvo Roque , Arteaga Ana
Published: December 2023

Heterogeneous systems of limited capacity have general applications in manufacturing, but also for logistic or service systems, due to the differences in server or workstation performance or work assignment, in close relationship with system flexibility, where saturation and blocking are ordinary situations of systems with high demand and limited capacity, so accurate loss quantification is essential for performance evaluation. Multi-class systems of limited capacity have been studied much less than parallel homogeneous systems (Erlang models). In this context, accurate models for parallel heterogeneous ordered-entry systems are developed: without any prior queue, M/Mi/c/c, and with a k capacity queue M/Mi/c/c+k. These new matrix models give an exact state formulation, and their accuracy is verified through discrete event simulation and comparison with literature results. Also, the effect of queue capacity is studied in relationship with the pattern of service rates. Next, the heterogeneous recirculating system model is also developed with good approximation results. Finally, the proposed models are applied to evaluate systems with non-exponential service times, through a new hybrid methodology by combining the Markovian model and the Monte Carlo Method (MCM) for normal or lognormal service times that also yield useful good approximations to the simulated system.
Machiavellianism in Mainstream Sustainability and Development: Re-imagining Alternative Futures through Empowerment
Authors: Adler Claudia Milena
Published: December 2023

Despite concepts of human flourishing, a term connected to empowerment that acts as an archi-tectural structure within the development and sustainability discourse, tensions remain between exponential economic growth, planetary health and community empowerment. Scholars argue that the development agenda is maldevelopment due to the unrequested interventions delivered to communities, mainly in the Global South (Shiva, 1999). A current state of disorientation grips the modern world, and despite sophisticated global frameworks like the Sustainable Development Goals (SDGs), internal approaches are side-lined. This research article repositions empowerment and compassion at the centre of the sustainable development discourse by drawing on the Inner Development Framework, particularly goal one – Being – ‘Relationship to Self’ and goal three – Relating – ‘Caring for others and the World’ as a guiding theoretical underpinning. Accordingly, this research article presents a qualitative interpretative study that examines the lived experience of women and their journeys to empowerment. The key findings indicate an intricate relationship between wellbeing and empowerment and the realisation of inner development as a tool to re-imagine alternative futures. The Machiavellian tendency to the sustainability agenda is deeply embedded in the profiteering of the misery of affected communities.
Selenium Compounds Affect Differently the Cytoplasmic Thiol/Disulfide State in Dermic Fibroblasts and Improve Cell Migration by Interacting With the Extracellular Matrix
Authors: Kreindl Christine , Soto-Alarcón Sandra , Hidalgo Miltha , Riveros Ana , Añazco Carolina , Pulgar Rodrigo , Porras Omar
Published: December 2023

Deficient wound healing is frequently observed in patients diagnosed with diabetes, a clinical complication that compromises mobility and leads to limb amputation, decreasing patient autonomy and family lifestyle. Fibroblasts are crucial for secreting the extracellular matrix to pave the wound site for endothelial and keratinocyte regeneration. The biosynthetic pathways for collagen production are one of the main components of the extracellular matrix, as the crosslinking of extracellular collagen fibers is intimately related to fibroblast redox homeostasis.
In this study, human dermic fibroblasts were cultured with 1 mM sodium selenite (inorganic) and 1 mM of two selenium amino acids (organic), Se-cysteine and Se-methionine. This concentration was compatible with long-term exposure necessary for extracellular matrix production and allowed us to examine the impact of these three compounds on the state and response of the thiol-based HyPer biosensor expressed in the cytoplasm. In addition, the abundance of extracellular matrix and ultrastructural properties were evaluated by Picrus Sirius red staining and scanning electronic microscopy, respectively. We also evaluated whether these selenium compounds effectively ameliorated the perturbations induced by culturing fibroblasts at high glucose levels (25 mM) regarding cytoplasmic redox, extracellular matrix, and glycation on collagen fibers.
Our results indicate that cytoplasm protein oxidation was sensitive to selenium compound supplementation. Selenium amino acids increased the sensitivity to protein oxidation, and only Se-cysteine increased the disulfide bond reduction in fibroblasts maintained in high glucose. Despite the lack of effect of selenium compounds on the glu-cose-induced increase in matrix fiber thickness, we found that endothelial migration improved in the matrix generated by high glucose-cultured fibroblasts.
The Role of APTES as a Primer for Polystyrene Coated AA2024-T3
Authors: IV John Halford , Chen Cheng-fu
Published: December 2023

The silane (3-Aminopropyl)triethoxysilane (APTES), possesses one terminal amine group and three ethoxy groups extending from each silicon atom, serving as a crucial interface adherent between organic and inorganic materials. In corrosion prevention, APTES is frequently employed as a primer, with subsequent topcoat as an extra protective layer. This topcoat is particularly useful in covering sites where APTES may exhibit poor bonding, such as those involving Cu or Cu-rich alloying elements. In our study, we applied a thin layer of APTES to cleaned AA2024-T3 samples using concentrated vapor deposition, followed by spin-coating with a diluted PS/acetone solution. Through combinatorial experimentation, we investigated the impact of APTES on the corrosion resistance of the coating system on AA2024-T3. Our findings indicate that a higher surface energy of the APTES primer contributes to better corrosion resistance in the overall coating system. This improvement can be attributed to enhanced wettability achieved by the PS/acetone solution on the cured APTES primer, leading to a more uniform coverage of the dried PS topcoat. Additionally, our research revealed that, in the early stages of exposure to the corrosion solution, a thinner APTES primer enhances protection against corrosion. This effect is attributed to hydrolytic stability mechanisms, and the interactions between hydrolyzation/condensation in soaked APTES and the dissolution of naturally formed aluminum oxide pre-existing in the bare samples. Finally, we observed that an APTES primer subjected to additional heat treatment before topcoating exhibits superior performance in corrosion resistance.
Bacteriophage T5 dUTPase: Combination of Common Enzymatic and a Novel Function
Authors: Glukhov Anatoly , Marchenkov Victor , Dzhus Ulyana , Krutilina Antonina , Selikhanov Georgii K. , Gabdulkhakov Azat
Published: December 2023

The main function of dUTPases is to regulate the cellular levels of dUTP and dTTP, thereby playing a crucial role in the DNA repair mechanisms. Despite the fact that mutant organisms with the obliterated dUTPase enzymatic activity remain viable, it is not possible to knockout the dut gene completely due to the lethal consequences of such mutation for the organism. As a result, it is considered that this class of enzymes perform an additional function that is essential for the organism's survival. In this study, we provide the evidence that the dUTPase of bacteriophage T5 possesses supplemental function in addition to its canonical role. We determined the crystal structure of bacteriophage T5 dUTPase with a resolution of 2.0 Å, and discovered a distinct short loop, consisting of 6 amino acid residues which represents unique structural feature specific to the T5-like phages dUTPases. The removal of this element did not affect the overall structure of the homotrimer, but had significant effects on the development of the phage. Furthermore, it has been shown that the enzymatic function and the novel function of bacteriophage T5 dUTPase are unrelated and independent from each other.
Study on Microstructure and Mechanical Properties of Portland Cement Incorporating Aluminosilicate Waste
Authors: Antonovič Valentin , Sikarskas Donatas , Boris Renata , Kudžma Andrius , Malaiškienė Jurgita , Stonys Rimvydas
Published: December 2023

The influence of aluminosilicate pozzolanic waste, specifically spent fluid catalytic cracking catalyst (FCCW) and metakaolin waste (MK) from expanded glass industry, on the properties of hardened Portland cement paste were analysed. The study involved replacing part of cement with FCCW and MK and observing their impact on hydration, microstructure, density and compressive strength of hardened cement paste. Various analysis methods were employed, including X-ray diffraction (XRD), thermogravimetric analysis (TG), and scanning electron microscopy (SEM), to understand the changes in the structure of hardened cement paste during hydration. The findings revealed that FCCW tends to accelerate cement hydration process due to its high surface area and pozzolanic activity. Notably, the formation of portlandite crystals was observed on FCCW particle surfaces in a specific direction. These crystals appeared smaller and developed in different directions in compositions containing a composite binder with mixture of FCCW and MK in a ratio 1:1. This could be influenced by pozzolanic reactions activated by fine particles of MK and the formation of calcium silicate hydrates (CSH) and calcium alumino silicate hydrates (CASH) in the presence of portlandite. XRD and TG results indicated that the specimens containing a composite binder exhibited the least amount of portlandite. The compressive strength of these specimens increased compared to control specimens, although the amount of cement was 9% lower.
Adaptation of the European Fish Index (EFI+) to include the alien fish pressure
Authors: Aparicio Enric , Alcaraz Carles , Rocaspana Rafel , Pou-Rovira Quim , García-Berthou Emili
Published: December 2023

The European Fish Index EFI+ is the only fish-based multimetric index for the assessment of the ecological status of running waters validated and thus applicable across the European Union. Metrics of the index rely on several attributes of the species present in the fish assemblage, irrespective of their native/alien status. The abundance of alien fish, together with other anthropogenic impacts, is one of the most important threats to the conservation of native fish and ecosystem health and is also an indicator of degraded stream conditions. Therefore, to improve the performance and utility of the EFI+ in regions with high incidence of alien species, the EFI+ was adapted to include the alien fish pressure by averaging the two original metrics with a new metric that reflects the number of alien species as well as the proportional abundance of alien individuals. The application of the adapted index (A-EFI+) is illustrated with data from several Iberian Mediterranean basins and showed similar or stronger correlations than the original EFI+ with anthropogenic pressure (land-use variables) and with other regional fish indices. EFI+ has been invaluable to intercalibrate fish indices across Europe and A-EFI+ is similar but explicitly includes the alien pressure, thus helping to provide a more comprehensive assessment of ecosystem health and to communicate it to society.
Use of Partial Least Squares Structural Equation Modeling (PLS-SEM) to improve Plastic Waste Management
Authors: Pereira Lucas Menezes , Sanchez Rodrigues Vasco , Freires Francisco Gaudêncio Mendonça
Published: December 2023

This paper aims to propose improvements for plastic waste management in Salvador – the Brazilian third most populated metropolis – via Partial Least Squares Structural Equation Modeling (PLS-SEM). All indicators, constructs, and hypotheses regarding collection, sorting, recycling, and disposal in the proposed PLS model were derived from the literature review, and the dependence of the performance construct on efficiency, effectiveness, municipality's socioeconomic aspects and municipality infrastructure is evaluated. Academic and practitioner publics were surveyed, and after analysis in both SmartPLS and RStudio software, suggestions for improvement regarding plastics recycling rate, market maturity, and infrastructural aspects for optimized reverse logistics were made. Since almost double the minimum number of respondents answered the survey questionnaire and the PLS-SEM statistics showed that the modeling presents consistency, the discussion is relevant. The model can and will evolve, but examples of suggested improvement are the installation of Deposit-Return Systems (DRS) in parks, streets, and avenues for increasing selective collection and the direct purchasing of waste from residents by municipal administration, compensating them with vouchers for food. The model can be a basis for other cities worldwide sharing analogous characteristics. By considering it, organizations can contribute to both reduced Greenhouse Gas (GHG) emissions and reduced terrestrial pollution.
Improvement of Industrial Maintenance Plans through Assisted-Driven Design RCM-CBR
Authors: Rodríguez-Padial Néstor , Marín Marta M. , Domingo Rosario
Published: December 2023

The present work provides continuity with studies where currently the industrial market is characterized by a highly variable demand in terms of quantities and flexibility of manufacturing or mass customization, which translates into a more demanding production context in terms of the continuous changes required to the production systems, the effect of which results in an increase in the fatigue subjected to the machines that make up the production systems. On the other hand, current production systems tend to use highly communicative and sensorized cyber-physical systems; these characteristics can be used to integrate them into decision-assisted systems in order to improve the availability of the industrial plant. The assisted system developed focuses on collecting and taking advantage of historical knowledge of industrial plant failures and breakdowns. By ideally integrating the Reliability Centered Maintenance (RCM) methodology and Case-Based Reasoning (CBR) algorithms implemented in a Java application, it is possible to design maintenance plans adjusted to a real and changing operational context of any industrial plant. As a result, faster and more accurate decisions are made, as they are based on data. This article focuses on improving certain aspects of the developed assisted system by adding more value to it by incorporating Fuzzy Logic (FL) techniques. The aim is to improve the way of entering information about risk factors and their relative importance, by incorporating natural language, instead of a numerical score, resulting in increased precision in the calculation of the Risk Priority Number (RPN) of the new cases incorporated into the assisted system.
Mechanical Weed Control: Sensor-Based Inter-row Hoeing in Sugar Beet (Beta vulgaris subsp. vulgaris L.) in Romania
Authors: Cioca Parasca Sergiu , Spaeth Michael , Rusu Teodor , Bogdan Ileana
Published: December 2023

Precision agriculture including camera-guided row detection and hydraulic steering are often used as an alternative because crop damage can be decreased and driving speed can be increased comparable to herbicide applications.The effects of different approaches as uncontrolled (UC), mechanical weed control (MWC), herbicide weed control (HWC) and mechanical + herbicide control (MWC+HWC) on weed density and yield of sugar beet were tested and evaluated in two trials (2021 and 2022) in South Transylvania at the tested intervals BBCH 19 and 31. Weed control efficacy (WCE) depends on the emergence of the weeds and a good timing of weed controls in all the trials and methods, though the highest yield of sugar beet roots was recorded in the treatment MWC+HWC, with an increase up to 12-15% (56.48 t ha-1) yield from HWC (50.22 t ha-1) and a yield increase of more than 35- 40% than MWC (42.34 t ha-1). Our trials show that is possible to increase yield and have less chemical applications with the introduction of the new precision technologies in agriculture included here the sensor-guided mechanical controls.
Application of Geographic Information Systems in Analysing Topographic Roughness for Nyanga District of Zimbabwe
Authors: Chipatiso Ezra
Published: December 2023

The Topographic Ruggedness Index (TRI) is one of the essential measurement in topographic analysis, as well as in explaining biodiversity and geo-diversity. This study demonstrate how to utilize Geographic Information Systems (GIS) to generate TRI for Nyanga District using Digital Elevation Model (DEM). Though the TRI strongly depends on a local scale slope derived from an average adjacent neighbor slope algorithm, and selection of different lag distances in the computation of spatial variability, the measurement demonstrated that areas of higher altitude have higher ruggedness index. The TRI model was generated by computing focal statistics to determine focal sum of DEM and of DEM ². The final TRI was computed using Math Algebra (Raster Calculator) to generate layers of different ruggedness suitable for topographic and biodiversity analysis. The algorithm presented could also be used for smaller areas with high quality data and corrected DEMs. Despite widespread adoption, ruggedness metrics require thorough testing using both artificial landscapes and real world applications.
Dirac’s Large Number Hypothesis: An Ongoing Quest for Correlations Between the Infinitesimal and the Infinite
Authors: Jiang Jonathan H. , Liu Ethan , Chen Yanbei
Published: December 2023

Dirac's Large Number Hypothesis (LNH), proposed in 1937, has captivated the scientific community with its exploration of profound correlations between cosmic and atomic scales. This hypothesis delves into the intricate interplay between the infinitesimally small and the vastly large, offering potential insights into the fundamental nature of the universe. As we continue to uncover the mysteries of the cosmos, the LNH oscillates on the precipice of scientific acceptance—neither fully validated nor entirely dismissed. In this review paper, we embark on a comprehensive journey through Dirac's LNH, shedding light on its theoretical underpinnings, its implications for universe models, and its resonance with the Anthropic Principle. We delve into the possibilities of variable gravitational constants and continuous mass creation, inviting further exploration into the intricacies of our cosmic symphony. By embracing the ongoing quest for understanding, we endeavor to unravel the profound harmonies that connect the infinitesimal with the infinite, contributing to the symphony of knowledge in theoretical physics and cosmology.
Pharmacotherapy of Dyslipidemias
Authors: Herling de Oliveira Lucas Lentini , Rodrigues de Assis Arthur Cicupira , Rocha Giraldez Viviane Zorzanelli , Scudeler Thiago Luis , Soares Paulo Rogério
Published: December 2023

Hypercholesterolemia plays a fundamental role in the development and progression of atherosclerosis. Current guidelines for treating dyslipidemia target low-density lipoprotein-cholesterol (LDL-C). Despite advances in the pharmacotherapy of atherosclerosis, the most successful agents used to treat this disease – statins – remain insufficient in the primary or secondary prevention of acute myocardial infarction. Advancing therapy for hypercholesterolemia with emerging new drugs, either as monotherapy or in combination, is expected to improve cardiovascular outcomes.
Effect of Accelerated Aging Tests in Salt Spray of Single Lap Friction Stir Welded Joints between S355-J0 Steel – AA5083 Aluminum Alloy. – Part 1 – Mechanical Tests
Authors: Chiara Borsellino , Favaloro Federica , Di Bella Guido
Published: December 2023

This study aims to investigate a friction stir welded joint between steel and aluminum alloy. Friction stir welding is nowadays one of the most interesting joining technique due to the possibility to connect materials and thicknesses that are difficult or impossible to weld with traditional techniques. The main advantage is that Materials are not affected by thermal cycle problems during solidification and cooling and the absence of fumes and pollution during the process favors the quality of the welded joint. The life of metal joints could be greatly reduced in a corrosive environment, since the less noble material will tend to increase its corrosion rate while the nobler one will reduce its electrochemical dissolution. Accelerated ageing tests (i.e. salt fog test) are used to estimate the lifetime of metal joints in highly aggressive environments. The aim of the present work is to evaluate the durability at long ageing time in salt spray test (according to ASTM B117) of carbon steel/aluminum alloy joints, obtained by FSW. In this first part, mechanical tests results are reported. A deep metallographic and chemical investigation are going to be reported in the part 2.
Regeneration of Non-Alcoholic Fatty Liver Cells Using Chimeric FGF21/HGFR: A Novel Therapeutic Approach
Authors: Kim Sung-Jun , Kim So-Jung , Hyun Jeongeun , Kim Hae-Won , Jang Jun-Hyeog
Published: December 2023

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant liver ailment attributed to factors like obesity and diabetes. While ongoing research explores treatments for NAFLD, further investigation is imperative to address this escalating health concern. NAFLD manifests as hepatic steatosis, precipitating insulin resistance and metabolic syndrome. This study aims to validate the regenerative potential of chimeric fibroblast growth factor 21 (FGF21)-Hepatocyte Growth Factor Receptor (HGFR) in NAFLD-afflicted liver cells. AML12, a murine hepatocyte cell line, was utilized to gauge the regenerative effects of chimeric FGF21/HGFR expression. Polysaccharide accumulation was affirmed through periodic acid-Schiff (PAS) staining, while LDL uptake was microscopically observed with labeled LDL. mRNA analysis via RT-PCR revealed reduced expression of key NAFLD markers, including acetyl-CoA carboxylase 1 (ACC1) and sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), alongside elevated levels of hepatocyte growth factor (HGF), hepatocyte nuclear factor 4 alpha (HNF4A), and albumin (ALB). These findings affirm the hepatoregenerative properties of chimeric FGF21/HGFR within AML12 cells, opening novel avenues for NAFLD therapeutic exploration.
Optimalisasi Sarana Hukum dalam Menanggulangi Kekerasan Seksual di Lingkungan Pendidikan dengan Kajian Sosiologi Hukum
Authors: Kusumo Andhika Satrio
Published: December 2023

Kekerasan seksual dapat terjadi karena tidak mampunya seseorang dalam hal menahan hawa nafsu. Ironisnya kekerasan seksual malah sering terjadi di lingkungan Pendidikan. Penelitian ini bertujuan untuk memberikan optimalisasi sarana hukum dalam menekan kasus Kekerasan Seksual baik dalam bentuk upaya preventif maupun represif. Penelitian ini merupakan penelitian hukum empiris yang diambil dari realitas yang ada. Perpaduan antara kajian sosiologis dengan hukum diharapkan mampu memberikan solusi terhadap permasalahan kekerasan seksual di lingkungan Pendidikan. Kajian sosiologi hukum membawakan warna baru dalam tafsir ilmu hukum. Dengan fakta tingginya kasus kekerasan seksual di lingkungan Pendidikan, maka perlu Tindakan tambahan selain hukum dalam bentuk hukuman penjara dan denda sebagai bentuk penanggulangan secara represif. Penulis mengkaji tentang upaya preferentif yang dapat dilakukan seperti sex education pada anak, sex parenting yang dilakukan orang tua pada anak, sharing discussion antar orang tua murid untuk mengetahui bagaimana perkembangan anak di lingkungan sekolah tersebut hingga Pendidikan dan/atau pelatihan khusus guna meningkatkan Sumber Daya Manusia Guru.
Tinjauan Etika dan Hukum Praktik Kedokteran Melalui Telemedicine Pasca Pandemi COVID-19
Authors: Dewayanti Irma , Suryono Arief
Published: December 2023

Dunia kini memasuki era Revolusi Industri 4.0, yaitu era dimana semuanya berbasis internet. Telemedicine merupakan salah satu bentuk kemajuan teknologi di bidang kesehatan. Telemedicine memberikan peluang terselenggaranya praktik kedokteran yang tidak lagi dibatasi oleh jarak dan keberadaannya semakin diminati masyarakat bahkan setelah pandemi COVID-19 berakhir. Meskipun memberikan manfaat, praktik kedokteran melalui telemedicine juga menimbulkan beragam masalah terutama apabila dikaitkan dengan etika dan hukum. Penelitian ini bertujuan untuk menganalisis pelaksanaan praktik kedokteran melalui telemedicine pasca pandemi COVID-19 ditinjau dari aspek etika dan hukum. Jenis penelitian yang digunakan adalah penelitian hukum normatif. Pendekatan yang digunakan adalah pendekatan perundang-undangan dan pendekatan konseptual. Ditinjau dari aspek etika (4 prinsip bioetika), praktik kedokteran melalui telemedicine kurang mempertimbangkan prinsip-prinsip etika kedokteran. Ditinjau dari aspek hukum, regulasi yang memberikan ruang bagi terselenggaranya telemedicine di Indonesia saat ini belum cukup lengkap. Peraturan perundang-undangan yang ada belum mengatur penyelenggaraan praktik kedokteran melalui telemedicine antara dokter dan pasien secara pribadi melalui perantara aplikasi kesehatan. Oleh karena itu, pemerintah bersama dengan kementerian kesehatan, kementerian lain yang berwenang, serta organisasi profesi yang bergerak di bidang kesehatan dapat bekerjasama dan bersinergi untuk membentuk pengaturan yang lebih rinci sehingga mampu memberikan kepastian hukum dan keamanan baik bagi pasien maupun dokter.
Penjatuhan Pidana Khusus Perkara Narkotika Atas Penerapan Asas the Binding Persuasive of Precedent
Authors: Puspitaningrum Aulia
Published: December 2023

Tindak pidana narkotika merupakan salah satu tindak pidana khusus yang juga secara khusus diatur melalui Undang-Undang Nomor 35 Tahun 2009 tentang Narkotika, dengan kata lain diatur di luar KUHP. Dalam memutus tindak pidana narkotika, hakim akan mempertimbangkan hal-hal tertentu sesuai dengan undang-undang terkait dan mengambil keputusan sesuai dengan keyakinannya dalam menegakkan hukum yang berkeadilan. Jenis penelitian yang digunakan adalah penelitian hukum normatif. Pendekatan yang paling relevan adalah pendekatan kasus (case approach) dengan melakukan telaah terhadap kasus atas putusan pengadilan yang juga telah berkekuatan hukum tetap (inkraht). Sumber bahan hukumnya yaitu bahan hukum primer dan bahan hukum sekunder dengan teknik pengumpulan studi kepustakaan, serta teknik analisis dalam penelitian hukum ini bersifat deduktif dengan menggunakan metode silogisme. Hasil penelitian menunjukan bahwa pertimbangan hakim dalam menjatuhkan pidana di bawah minimum khusus dapat menggunakan beberapa tolak ukur seperti melihat usia terdakwa yang di bawah umur atau lanjut usia, keterlibatan terdakwa dalam tindak pidana narkotika, berat barang bukti narkotika yang diperoleh dari terdakwa, dan kemungkinan terdakwa mengulangi tindak pidananya tersebut. Konsekuensi hukum penjatuhan sanksi di bawah minimum khusus atas penerapan asas the binding persuasive of precedent berkaitan dengan aspek keadilan yakni akan terbuka kemungkinan menyebabkan disparitas pidana yang pada akhirnya terpidana tersebut akan merasakan ketidakadilan dan menjadi korban dari diskriminasi penegakan hukum.
OVERCOMING CAD DISADVANTAGES IN THE CONSTRUCTION OF DETAIL DRAWINGS IN ACCORDANCE WITH THE REQUIREMENTS OF CURRENT STANDARDS
Authors: Ivanov Evgueny
Published: December 2023

The paper proposes a method for improving the construction of parametric three-dimensional models of parts and the execution of drawings to solve the problems of compliance with the requirements of current standards, in particular, the depiction of sections of parts in drawings in the Autodesk Inventor package. To solve this problem, it was proposed to use an additional parametric three-dimensional hollow element that uses the geometric information of thin walls, lugs, etc. and is tied to the sectional plane. Using the functionality of the Autodesk Inventor package, a parametric three-dimensional hollow element is built, which along the transverse plane has a size proportional and comparable to the size of thin walls, ears, etc., differing in infinitesimal value. The size of a parametric three-dimensional hollow element perpendicular to the direction of the cross-sectional plane, on the contrary, is incomparable to the size of thin walls, ears, etc. For the convenience of using a hollow three-dimensional element, it is proposed to place it in such a way that the transverse plane is the plane of symmetry for it. Such a position facilitates the use of a hollow three-dimensional element when depicting thin walls, ears, etc. on orthogonal projections in accordance with the requirements of current standards. In order to meet the requirements of current standards for axonometric projections, the sectional plane is shifted relative to the axis of symmetry beyond the hollow element of thin walls, lugs, etc. that fall into the section. Since the width of the hollow element was set as an infinitesimal value, when the sectional plane is shifted relative to the symmetry axis, the hollow element of walls, lugs, etc. is hatching. Under these conditions, by performing an axonometric projection with a longitudinal section, we obtain a minimum error in the location of the sectional plane relative to the symmetry axis of the part. The conditions for building the element(s) allow you to hide it if necessary. The construction of an additional three-dimensional hollow element(s) does not require knowledge of the built-in VBA programming language and the use of iLogic tools.
Keywords: conventions and simplifications of images, projection views, axonometric, parametric hollow area, toolset, Autodesk Inventor package
ANALYSIS OF DESIGNS, MODELS AND METHODS OF STUDYING THE DYNAMICS OF HIGH-ROTATION ELEMENTS OF TANK ENGINES (REVIEW ARTICLE)
Authors: Tkachuk Mykola А. , Nazarenko Sergej , Grabovskiy Andrey , Tkachuk Mykola M. , Shut Oleksandr , Lipeiko Andrii , Veiler Volodymyr , Marusenko Oleksiі , Prokopenko Mykola , Marusenko Svitlana , Vasiliev Anton , Hrechka Iryna , Khramtsova Iryna
Published: December 2023

A lot of problems arise when tank engines are equipped with high-speed elements. They are related to the need of analyzing the stress-strain state and critical modes of rotation of these elements. For that reason, it requires an in-depth analysis of requirements and constructive solutions of engines and their high-speed elements. Moreover, modern studies of engine dynamics attract attention. Attention should also be paid to the analysis of existing designs of turbocharging systems of tank engines. It is important to analyze the models and research methods of the static and dynamic stress-strain state of turbocharger impellers as well. The analysis of problem aspects has been carried out and it is possible to note that for now the problem of studying the stress-strain state and critical modes of rotation of high-speed elements of tanks and engines for armored vehicles does not have a complete solution. We need new approaches, models and research methods and tools that create a basis for substantiating progressive technical solutions.
Keywords: armored vehicles; tank engines; turbocharger; high-speed elements; stress-strain state
Identifikasi Desa Sebagai “Lewu Proklim” di Kabupaten Pulang Pisau
Authors: Hukom Alexandra , Muhamad Iqbal Rendy , Nomeritae Nomeritae , Abdurahman Ravenalla
Published: December 2023

Desa Pro Iklim adalah program pemerintah dalam rangka meningkatkan keterlibatan masyarakat dalam melakukan aksi adaptasi dan mitigasi perubahan lingkungan serta penurunan emisi gas rumah kaca. Penelitian ini bertujuan untuk mengidentifikasi Desa yang ada di sepanjang jalan trans Kalimantan dan berada di tepian sungai Kahayan. Jenis penelitian ini adalah penelitian deksriptif dengan menggunakan analisis SWOT, dengan ditemukannya Desa Pilang berdasarkan Pedoman Program Proklim dapat dijadikan sebagai Lewu Proklim. Hasil analisis menunjukan bahwa memperkuat strategi sosialisasi secara intensif untuk memperkenalkan program kampung iklim kepada masyarakat. Adaptasi dengan menambah saluran irigasi, penampungan air hujan dan mengembangkan kebun percontohan yang telah digunakan sebagai pakan orangutan di Konservasi Pelepasliaran Orang Utan. Mitigasi dengan membiasakan masyarakt untuk menggunakan pupuk organik dan menggalakan kegiatan penanaman pohon secara insentif terutama di pesisir Sungai Kahayan. Partisipasi dengan mendayagunakan tokoh masyarakat sebagai panutan dan mengadakan acara adat secara ritual untuk menjalin komunikasi antar warga dan pendekatan budaya dan agama.
Pengabdian Masyarakat di Desa Gedangan Tahun 2019
Authors: Mariyati Lely Ika
Published: December 2023

Puji syukur kepada Tuhan Yang Maha Esa, karena telah melimpahkaan Rahmat Nya berupa kesempatan dan pengetahuan sehingga Buku Pengabdian Masyarakat di Desa Gedangan Tahun 2019 dapat selesai pada waktunya. Pelaksanaan pengabdian masyarakat dilakukan pada masyarakat desa Gedangan, Kecamatan Gedangan, Kabupaten Sidoarjo dengan tema “Pengembangan Desa Delta Mandiri Berkemajuan Dengan Pendekatan Sosiokultural Dan Teknologi Berkelanjutan”. Desa Gedangan atau kelurahan Gedangan kecamatan Gedangan Sidoarjo secara geografis berada di sepanjang jalan Arteri Sekunder (jalan provinsi) terletak 7,3 km dari jantung kota sidoarjo, dengan jarak tempuh sekitar 1 jam 6 menit dengan menggunakan mobil atau sepeda motor. Desa Gedangan adalah salah satu desa dengan pemukiman dengan padat penduduk, kurangnya lahan kosong dan sistem drainase yang buruk mengakibatkan desa Gedangan menjadi rawan banjir, pola oknum warga yang kurang juga menyumbang volume sampah yang sudah menumpuk.
Pengabdian Masyarakat di Desa Keboananom tahun 2019
Authors: Mariyati Lely Ika
Published: December 2023

Puji syukur kehadirat Allah SWT, yang telah memberikan rahmat dan hidayah-Nya sehingga kami dapat menyelesaikan Buku Pengabdian kepada Masyarakat di Desa Keboananom Tahun 2019. Pelaksanaan pengabdian masyarakat dilakukan pada Desa Keboananom, Kecamatan Gedangan, Kabupaten Sidoarjo dengan tema “Meningkatkan Desa Hijau dan Sehat berbasis Teknologi Berkelanjutan” mulai dari tanggal 1 Agustus sampai 6 Oktober 2019. Desa Keboananom merupakan salah satu Desa yang berada di Kecamatan Gedangan. Mayoritas penduduk yang cukup tinggi dapat dilihat pada padatnya rumah penduduk. Kurangnya daerah resapan air yang menjadikan desa ini banjir ketika turun hujan dan belum adanya tempat pembuangan akhir. Program pengabdian masyarakat ini bertujuan untuk mengembangkan kemampuan sumber daya masyarakat, melakukan pengadaan sosialisasi, workshop, taman toga, vertikal garden dan label produk UMKM serta menerbitkan sebuah buku sebagai tujuan akhir dari program pengabdian masyarakat.