bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical Characteristics of Industrial Geological Parameters and Their Implications in Uranian Overview of Pa Lua - Pa Rong Area
Authors: Chau Tran Le , Phuong Nguyen , Giang Nguyen Truong , Tam Le Quyet , Phu Nguyen Tien , Than Nguyen Dinh , Huan Trinh Dinh
Published: August 2023

This study investigated the geological properties of the uranium ore found in Pa Lua - Pa Rong area for potential industrial exploitation. A combination of field measurements, modeling and several mathematical approaches were employed to characterize the geological properties of the uranium ore. We found: i) The thickness of the ore bodies ranges from thin to medium, exhibiting varying degrees of instability (Vm = 83.8÷102.8%). The average U3O8 content indicates that the ore bodies belong to the poor ore type, with an unevenly distribution (Vc = 57.9÷100.9%); ii) The morphology and structure of the ore bodies are highly complex, exhibiting irregular variations. The thickness of the ore bodies shows a positive correlation with the uranium content in each body (R = 0.6-0.7); iii) The variograms of the U3O8 concentration and the thickness in various directions exhibit a spherical pattern, indicating an autogenous effect. The most significant variation in uranium content aligns with the dip direction (50°±12.5°), while the least variation aligns with the strike of the ore body (140°±12.5°). The variations in ore body thickness are more straightforward and consistent with those of the uranium content. In summary, these findings provide valuable insights into the characteristics of uranium ore in Pa Lua – Pa Rong area. The results contribute to a better understanding of the geological processes and can inform some effective exploration strategies for uranium resources in this region.
EXTENSÃO UNIVERSITÁRIA COMO ESTRATÉGIA DO PROCESSO DE ENSINO-APRENDIZAGEM NA PSICOLOGIA: UMA VISÃO A PARTIR DO SOFTWARE IRAMUTEQ
Authors: Do Monte Washington Sales , Porto Maria Vera Lúcia Pessoa , Trindade Maria Camilla Souza , De Lima Lia Rodrigues Lessa , Moura Karidja Kalliany Carlos de Freitas
Published: August 2023

A pesquisa Extensão Universitária como estratégia do processo de ensino-aprendizagem na psicologia trata de uma investigação que tem como hipótese, que a extensão universitária, no âmbito da psicologia, embora possa vir a ser útil e propícia ao crescimento em várias áreas da vida, ainda engatinha. Por isso, o objetivo é investigar como se desenvolve os trabalhos de extensão em psicologia, bem como seu impacto na qualidade de vida das comunidades atendidas por projetos ou ações extensionistas. O método, utilizado será, inicialmente, o quantitativo, através da busca na plataforma Scielo de artigos que exponham ideias e ações a respeito do tema para, em seguida, após apuração dos dados, dissertar qualitativamente acerca do tema proposto. A pesquisa, então, dará continuidade e como resultado é possível perceber que as publicações não são recentes na área da psicologia, porém com processamento de dados de escrita científica sobre o contexto da extensão universitária na psicologia, como considerações finais da nossa investigação, foi possível perceber a impotência das atividades de extensão para o desenvolvimento de habilidades pessoas e profissionais dos alunos dentro do contexto das demandas sociais e integração entre a universidade e comunidade onde está inserida.
SADTU and the Struggle for Professional Unionism, edited by Michael Cross, Logan Govender and Ahmed Essop
Authors: Cooper Linda , Gamble Jeanne
Published: August 2023

University of KwaZulu-Natal Press. 2023. pp. 249.
ISBN: 9781869145224 / 1869145224
Anxiety Levels Among Emergency Unit Turkey Nurses During the Covid-19 Pandemic
Authors: Ovayolu Özlem , Ovayolu Nimet , Bebek Sinem , Ayyıldız Devran
Published: August 2023

The aim of the present study was to assess the anxiety level of nurses working in the emergency room during the COVID-19 pandemic. Nurses working at a hospital's emergency department between October 2, 2022, and November 15, 2022, participated in this descriptive study. Permission was obtained from the ethics committee, the institution, and the nurses prior to the study. The study's results were gathered using a face-to-face interview technique using a questionnaire—the State and Trait Anxiety Inventory. The data was analysed using the Shapiro-Wilk, Mann-Whitney U, and the Kruskal Wallis tests. According to the findings, the majority of the nurses were between the ages of 26 and 34, undergraduates, and female. The mean scores of the State and Trait Anxiety Inventory of the nurses were found to be 46.0±9.6-47.1±9.2, respectively. It was determined that gender, age, education level, number of people living together, chronic illness, working conditions and increased workload increased the state-continuity anxiety score. It was also determined that there was a significant relationship between working order, alcohol use, exposure to violence and the State-Trait anxiety score. It was concluded that nurses had moderate anxiety. It was determined that working conditions, prolonged working hours, and lack of personnel increased this level of anxiety. It is advised to assess emergency room nurses' anxiety levels, identify the variables that exacerbate anxiety, and take the required precautions.
WORK LIFE BALANCE IBU BEKERJA YANG MEMPUNYAI ANAK USIA DINI SELAMA PANDEMI
Authors: Ivana Brigita , Partasari Wieka Dyah
Published: August 2023

The aim of this research is to see working mother’s work life balance with early childhood childrenduring work from home era due to the COVID-19 pandemic. This research uses a qualitativephenomenological method with semi-structured interviews and thematic analysis. Participantsconsisted of 3 working mothers that have a child or children around 3-5 years old, work in acompany owned by another party at least 40 hours a week, and currently doing work from home.Participants were chosen using purposeful sampling homogeneous method. Analysis showsdifferent levels of work life balance between all three participants, and only one of them experiencework life balance. These differences influenced by factors such as participant’s career aspiration,types of job, support from partner and family, as well as the partner’s type of work. Therecommendation for future research is to look for the impact of partner’s type of work to theintensity of parenting task distribution. Future research can also look for the impact of careeraspiration to working mother’s satisfaction and work life balance. In an era where remote workis increasingly common, this research is expected to provide an overview of how working mothersdivide their roles, so that companies can make policies based on this situation. The research isalso expected to be useful for career women who are not married or do not have children yet to beable to plan a more mature future with their partner, both in the context of role division and mentalreadiness.
HUBUNGAN ANTARA WORK LIFE BALANCE DAN WORK ENGAGEMENT PADA KARYAWAN DI PT.X
Authors: Lie Erika , Sukmarani
Published: August 2023

Although work-life balance is not a new topic, the multidimensional perspective of work life balance has not been extensively studied. The purpose of this research is to evaluate the relationship between the dimensions of work-life balance and work engagement among employees, using a multidimensional perspective of work-life balance. This study used a qualitative approach, distributing online questionnaires to 37 participants, utilizing the Work Life Balance Scale andthe Utrecht Work Engagement Scale version 9 as measurement tools. Data analysis was conducted using Pearson’s Correlation statistical technique. The findings of the study showed a significant positive correlation between the demands dimension of work-life balance and work engagement. Similarly, a significant positive correlation was indicated between the resources dimension of work-life balance and work engagement. These findings suggest that studying work-life balance from a multidimensional perspective helps to achieve a more specific understanding of work-life balance, particularly in relation to work engagement. The multidimensional model of work-life balance is encouraged to be more widely used in the future research studies.
The anesthetic surgical act increases cognitive decline in older patients compared to a healthy population
Authors: Labos Edith , Albite Romina , Golimstok Angel , Renato Alejandro , Fernández M. Cecilia , Bonofiglio Francisco
Published: August 2023

Background and Objective: The purpose of this study was to investigate whether anesthetic surgical act is a risk factor that contributes to the development of postoperative cognitive dysfunction (POCD) in elderly patients, or whether there are pre-existing conditions that predispose it. Materials and Methods: The study involved a non-randomized prospective cohort of patients over 65 years of age undergoing surgery/anes- thesia (as well as a group of healthy individuals who were not exposed to either anesthesia or surgery). The study was carried out at the Hospital Italiano Buenos Aires between April 2017 and March 2020, and the data was collected in the anesthesia service. A total of 200 participants were evaluated, 100 in each group. A battery of cognitive tests was administered at baseline and 12 months later. Cognitive impairment was assessed with scales and analyzed by multivariate and principal component analysis. Results: At 12 months, exposed patients had a 36% incidence of deterioration, while unexposed patients had only 8%. The odds ratio was 6.5 (95% CI 2.9-15.8 p < 0.001). Adjusting for increased to 8.6 (95% CI 3.6-22.9 p < 0.001). Main components were identified that were correlated with the cognitive scales. The crude relative risk derived from the odds ratio was 4.5, while the adjusted relative risk was 7.3. Conclusions: The findings validate the existence of durable cognitive performance results in patients who were exposed. It is essential to stress the importance of performing a cognitive assessment before administering anesthesia and/or surgery to identify vulnerable people and continue monitoring their evolution.
Vaccination schemes and CoronaVac: Are there differences between adults and older adults hospitalized by COVID-19?
Authors: Cárdenas Catalina , Rojas Loreto , Morales Valenzuela Julio , Pinos García Yazmín Ivana , Silva Elgueta María Teresa , Kappes María
Published: August 2023

Antecedentes: Existe evidencia insuficiente para comparar diferentes esquemas de vacunación COVID-19 con CoronaVac en las poblaciones de adultos y adultos mayores. Métodos: Se realizó un estudio multicéntrico prospectivo con pacientes ingresados para hospitalización por COVID-19. Resultados: Un estudio de 159 pacientes con COVID-19 encontró que los pacientes más jóvenes no vacunados tenían un mayor riesgo de requerimiento de oxígeno (RR = 1,3, p = 0,041) y disnea (p = 0,002). Las hospitalizaciones en cuidados intensivos y el requisito de ventilación mecánica invasiva fueron menos frecuentes en las vacunas CoronaVac que en las personas no vacunadas. Los pacientes vacunados con CanSino y BNT162b2 presentaron niveles más bajos de dímero D que los vacunados con CoronaVac. Sin embargo, los individuos vacunados menores de 60 años no tuvieron un riesgo de muerte diferente al de los no vacunados al presentar COVID-19 grave, lo que indica una inmunidad inducida por la vacuna insuficiente. Conclusiones: CoronaVac tiene una mejor respuesta en adultos mayores que en jóvenes, y el estado de vacunación no difirió, significativamente, en individuos jóvenes con enfermedad grave. Los estudios futuros deberían examinar los efectos de diferentes vacunas en diferentes grupos de edad y su seguimiento a largo plazo, lo que puede ayudar a los países a tomar decisiones informadas para la vacunación de adultos mayores contra COVID-19.
Necrólisis epidérmica toxica: Presentación de un caso
Authors: Soto Maximiliano , Hernández Fridda P.
Published: August 2023

La necrólisis epidérmica tóxica (NET) y el Síndrome de Steven Johnson (SSJ) son entidades que se teorizan tienen un principio inmunológico en donde el papel principal de antígeno es dado principalmente por fármacos, causando una cascada de reacciones inmunitarias con la formación de sustancias que promueven el daño y muerte celular de los queratinocitos, con posterior desprendimiento de la epidermis. Este caso se trata de un paciente que curso con diagnóstico de NET donde se instauraron medidas farmacológicas y generales tempranas, y a pesar de esto el paciente tuvo evolución tórpida con sobreinfección por
Bilateral rectus sheath block as the sole anesthetic technique for urgent incarcerated umbilical hernia repair
Authors: Sepúlveda Haro Enrique , Torres Varona Jaime , Romero Molina Salvador , Cañero Ávila Juan M.
Published: August 2023

El bloqueo de la vaina de los rectos es una técnica analgésica interesante para la reparación de la hernia umbilical y hay casos descritos donde incluso se ha usado como único anestésico. Describimos el caso clínico de un paciente que precisó reparación urgente de una hernia umbilical incarcerada y que fue manejado con éxito con un bloqueo de la vaina de los rectos bilateral junto con sedación ligera. El bloqueo ecoguiado de la vaina de los rectos bilateral aportó anestesia quirúrgica para nuestro paciente, evitando los riesgos de la anestesia general y espinal en su peculiar situación clínica y consiguió una analgesia posoperatoria excelente, una rápida recuperación y alta hospitalaria sin complicaciones.
Efeitos da extubação precoce após cirurgia cardíaca infantil
Authors: Freitas Milton Halyson Benevides de , Freitas Marcio Handerson Benevides de , Menezes Neto Antônio Raphael de , Menezes Pedro Affonso Ferreira de , Campos Netto João de Almeyda , Patriota Hugo Vasconcelos , Souza Gabriel Carneiro Ferreira , Carneiro Danyelle Fonseca Rodrigues , Silva Liniker Scolfild Rodrigues da , Figueiredo José Luiz de
Published: August 2023

Objetivo: Evidenciar, a partir da literatura, quais as repercussões da extubação precoce realizada na criança após cirurgia cardíaca. Métodos: Trata-se de uma revisão integrativa. Para elaborar a questão norteadora, aplicou-se a estratégia PICo: P - Criança; I - Repercussões de cirurgia cardíaca; Co - Extubação precoce. Ainda, utilizou-se as seguintes bases de dados: Embase, Medical Literature Analysis and Retrieval System Online, SCOPUS, Web of Science, e a biblioteca virtual Scientific Electronic Library Online e busca atemporal. Foram encontrados n = 6.836 estudos, sendo selecionado n = 4 artigos para compor esta revisão. Resultados: A realização da extubação precoce após o procedimento cirúrgico cardíaco ganhou destaque nos últimos anos, tornando-se uma prática dos cuidados perioperatórios, capaz de reduzir a demanda por medicamentos analgésicos e sedativos, visto que a intubação endotraqueal pode ser considerada um estimulante nocivo. Considerações finais: Logo, foi possível compreender as repercussões da extubação precoce após a cirurgia cardíaca pediátrica, além de entender as preocupações relacionadas à segurança desta prática, devido às evidências limitadas do seu uso para as crianças. Ainda, percebeu-se a escassez de estudos relacionados à temática, ressaltando a necessidade de novas pesquisas que abordem os efeitos da extubação precoce e suas repercussões para o paciente pediátrico.
BIOSYNTHESIS AND CHARACTERIZATION OF CuO NANOPARTICLES USING DIFFERENT pH
Authors: Omar Sanya S. , Mohammed Raghad Y.
Published: August 2023

CuO nanoparticles are synthesized from Ferulago angulate leaf extract under different pH values. The structural, morphological, as well as optical properties of the green synthesized CuO NPs are studied. Besides, the functional groups in the Ferulago angulate stabilizer capping the copper nanoparticles were examined using FTIR spectra. The primary factor that led to the first confirmation of CuO NP production was the reaction mixture's color change. A phytochemical test revealed the presence of proteins, amino acids, carbohydrates, flavonoids, phenols, alkaloids, tannins, and saponins. FTIR spectrum shows a  peak at 532.35 cm-1, this may be attributed to CuO's vibrations confirming the presence of copper oxide nanoparticles. XRD analysis shows the presence of crystalline monoclinic cupric oxide (CuO). The morphological study (FESEM) shows different morphology (different shapes and sizes) under different pH values. EDS data shows the O-richness of the prepared CuO NPs extracted from Ferulago angulate [ Schltdl.] BOISS leaf extract shows pure CuO phases. In this investigation, fabricated CuO's estimated energy band gap values were higher than those of bulk CuO. Results show Eg increment with increasing pH values.
“In Memory of Tatoe”: Who Owned the Album from the Collection of N.P. Smirnov-Sokolsky
Authors: Isachenko Tatiana A.
Published: August 2023

The article describes a little-known source — the literary almanac of 1886 “From day to day”, which includes 365 quotations from various works of M.Yu. Lermontov. Compiled by the Greek Queen Olga (nee Grand Duchess Olga Konstantinovna, granddaughter of Nicholas I), it had a limited printing and was intended for gifts to especially close people on memorable dates as a diary album for recordings. The history of the existence of each surviving copies of this rare edition is worthy of close study, so long as it gives the opportunity to verify a number of facts important for the native culture. This is a multi-level artifact containing autographs of famous people, reflecting a significant array of events, dates, names and poetic images. The article describes for the first time a copy from the library of the famous bibliophile N.P. Smirnov-Sokolsky, in which most of the inscripts belong to representatives of the House of Romanov and their aristocratic entourage (some of the personalities are established for the first time). For this purpose different data have been used with the help and by means of archival and bibliographic heuristics, as well as historical genealogy.
OECD ülkelerinde gelir dağılımı adaletsizliğinin doğumda yaşam beklentisi ile ilişkisinin Hellinger Korelasyon Analizi ile ölçülmesi
Authors: YÜCEL Leyla
Published: August 2023

Bu çalışma, “doğumda yaşam beklentisi” ve “gelir dağılımı adaletsizliği” arasındaki ilişkinin Hellinger korelasyon analizi ile ölçülmesini konu almaktadır. Analizler 2019 yılı verileri üzerinden 29 OECD ülkesi için gerçekleştirilmiştir. Gelir dağılımı adaletsizliğini temsilen, Gini katsayısı ve Palma oranı kullanılmıştır. Çalışmanın birincil amacı, klasik Pearson korelasyon analizi ile anlamlı sonuç vermeyen “doğumda yaşam beklentisi” ile “gelir dağılımı adaletsizliği” arasındaki ilişkinin, Hellinger korelasyon analizi uygulandığında anlamlı olup olmadığını araştırmaktır. Çalışmanın bir diğer amacı ise, gelir dağılımı adaletsizliğinin doğumda yaşam beklentisi üzerindeki etkisinin, cinsiyetlere göre farklılık gösterip göstermediğini ortaya koymaktır. Bu nedenle, doğumda yaşam beklentisi değişkeni; toplam nüfusun doğumda yaşam beklentisi, kadınlar için doğumda yaşam beklentisi ve erkekler için doğumda yaşam beklentisi şeklinde üç ayrı kategoride ele alınmıştır. RStudio 4.0.5. HellCor paketi kullanılarak gerçekleştirilen uygulamalar sonucunda; klasik Pearson korelasyon analizi ile ölçülen ilişkilerin tamamı istatistiksel olarak anlamsız bulunurken, doğumda yaşam beklentisi ile Gini katsayısı arasındaki tüm Hellinger korelasyon katsayıları 1’e yakın, çok yüksek ilişkili bulunmuştur. Fakat aynı durum Palma oranı için geçerli değildir. Doğumda yaşam beklentisi ile Palma oranı arasındaki tüm Hellinger korelasyon katsayıları düşük bulunmuştur. Bu durumun, Gini katsayısı ile Palma oranının hesaplanma yöntemlerinin farklı olmasından kaynaklandığı düşünülmektedir. Çalışmada ayrıca, gelir dağılımı adaletsizliğinin, hem kadınların hem de erkeklerin doğumda yaşam beklentileri ile ilişkisinin benzer olduğu; gelir dağılımı adaletsizliğinin, cinsiyetlerden bağımsız olarak, tüm toplumun yaşam beklentisi ile yüksek ilişkili olduğu sonucuna varılmıştır.
Multi-Stage Condensation Pathway Minimizes Hysteresis in Water Harvesting with Large-Pore Metal-Organic Frameworks
Authors: Zaragoza Alberto , Factorovich Matias , Molinero Valeria
Published: August 2023

Metal-organic frameworks (MOFs) have emerged as promising materials for atmospheric water harvesting (AWH). Large-pore MOFs provide high water capacity, but their significant hysteresis between sorption and desorption makes them unsuitable for AWH. Co2Cl2(BTDD) is a noteworthy exception. This MOF has large, 2.2 nm diameter one-dimensional pores, and combines both record-high water capacity and minimal hysteresis, making it an excellent material for water capture in arid areas. Sorption reversibility in Co2Cl2(BTDD) has been attributed to continuous water uptake. However, the sharp adsorption/desorption in the isotherms supports a discontinuous first-order transition. Here we use molecular simulations to compute the water adsorption and desorption pathways and isotherms in a Co2Cl2(BTDD) model, to elucidate how does this MOF achieve reversibility despite its large pore size. The simulations reveal a multi-stage mechanism of discontinuous water uptake facilitated by spatial segregation of rows of hydrophilic metal sites bridged by ~1 nm hydrophobic ligands. The multi-stage mechanism breaks the barrier of capillary condensation into smaller, easier to surmount ones, resulting in a facile process despite the sharp density discontinuity between confined liquid and vapor. Our results explain why exchanging Co2+ for Ni2+ or Cl- for F- in the MOF have minimal impact on the condensation and desorption pressures. On the other hand, we predict that a decrease in hydrophilicity of the MOF vertices would strongly increase the hysteresis. We expect that the relationships between spatial distribution of hydrophilic sites and hysteresis unraveled in this study assist the design of water harvesting materials with maximal capacity and reversibility.
Probing the dynamic landscape of peptides in membrane mimics by synergized NMR experiments and MD simulations
Authors: Nencini Ricky , Regnier Morgan , Backlund Sofia , Mantzari Efstathia , Dunn Cory , Ollila Samuli
Published: August 2023

Dynamic interactions between peptides and lipid membranes are crucial in many biological processes and biomedical applications However, monitoring of peptide dynamics in a membrane environment has been limited by the lack of experimental methods that could directly detect the fast (picosecond to nanosecond) timescale dynamics of peptides in this environment. Spin relaxation times from nuclear magnetic resonance (NMR) experiments are sensitive to such motions, but their applications are often limited by complications in sample preparation and interpretation of the data. Here we show that the detailed dynamic landscape of peptide-membrane mimics can be determined by a synergistic combination of solution state NMR experiments and atomistic resolution molecular dynamics (MD) simulations. Solution state NMR experiments are straightforward to implement without an excessive amount of sample, while direct combination of spin relaxation data to MD simulations enables detailed interpretation of the dynamic landscapes of both peptide and membrane mimics. The interpretation of NMR data from transmembrane, peripheral, and tail anchored peptides indicate that peptides and detergent molecules do not rotate together as a rigid body. Instead, peptides appear to rotate when placed in a viscous medium composed of detergent micelle. On the other hand, spin relaxation times also provide indirect information on peptide conformational ensembles. This work gives new perspectives on peptide conformational ensembles and dynamics in membrane environments.
A Cutoff-based Method with Charge-distribution-data Driven Pair Potentials for Efficiently Estimating Electrostatic Interactions in Molecular System
Authors: Fukuda Ikuo , Moritsugu Kei , Higo Junichi , Fukunishi Yoshifumi
Published: August 2023

We introduce a simple cutoff-based method for precise electrostatic energy calculations in molecular dynamics (MD) simulations of point particle systems. Our method employs a theoretically derived smooth pair potential function to define electrostatic energy, offering stability and computational efficiency in MD simulations. Instead of imposing specific physical conditions, such as dielectric environments or charge neutrality, we focus on a relationship represented by a single summation formula of charge-weighted pair potentials. This approach allows accurate energy approximation for each particle, enabling straightforward error analysis. The resulting particle-dependent pair potential captures charge distribution information, making it suitable for heterogeneous systems and ensuring enhanced accuracy through distant information inclusion. Numerical investigations on the Madelung constant of crystalline systems validate the accuracy of the method.
Enhancing Gas Separation Selectivity Prediction through Novel Descriptors
Authors: Ren Emmanuel , Coudert François-Xavier
Published: August 2023

Adsorption-based techniques for gas separation using nanoporous materials are widely used and hold a promising future, but systematic identification of the best-performing materials for a given application is still an open problem. For that task, we need to estimate selectivity at different operating conditions (temperature, pressure) on a large set of nanoporous structures. To this aim, we have developed a machine learning-assisted screening process based on a fast grid calculation of interaction energies, in addition to newly designed geometrical descriptors to predict ambient-pressure selectivity. As a proof of concept, we tested our methodology for the separation of a 20-80 xenon/krypton mixture at 298 K and 1 atm in the nanoporous materials of the CoRE MOF 2019 database. Based on a standard train/test split of the dataset, our model is promising with an RMSE of 2.5 on the ambient-pressure selectivity values of the test set and 0.06 on the log10 of the selectivity. This method can thence be used to pre-select the best performing materials for a more thorough investigation.
Representing structures of the multiple conformational states of proteins
Authors: Ramelot Theresa , Tejero Roberto , Montelione Gaetano
Published: August 2023

Biomolecules exhibit dynamic behavior that single-state models of their structures cannot fully capture. We review some recent advances for investigating multiple conformations of biomolecules, including experimental methods, molecular dynamics simulations, and machine learning. We also address the challenges associated with representing single- and multiple-state models in data archives, with a particular focus on NMR structures. Establishing standardized representations and annotations will facilitate effective communication and understanding of these complex models to the broader scientific community.
c-JUN is a barrier in hESC to cardiomyocyte transition
Authors: Zhong Hui , Zhang Ran , Li Guihuan , Huang Ping , Zhang Yudan , Zhu Jieying , Kuang Junqi , Hutchins Andrew P , Qin Dajiang , Zhu Ping , Pei Duanqing , Li Dongwei
Published: August 2023

Loss of c-JUN leads to early mouse embryonic death, possibly because of a failure to develop a normal cardiac system. How c-JUN regulates human cardiomyocyte cell fate remains unknown. Here, we used the in vitro differentiation of human pluripotent stem cells into cardiomyocytes to study the role of c-JUN. Surprisingly, the knockout of c-JUN improved cardiomyocyte generation, as determined by the number of TNNT2+ cells. ATAC-seq data showed that the c-JUN defect led to increased chromatin accessibility on critical regulatory elements related to cardiomyocyte development. ChIP-seq data showed that the knockout c-JUN increased RBBP5 and SETD1B expression, leading to improved H3K4me3 deposition on key genes that regulate cardiogenesis. The c-JUN KO phenotype could be copied using the histone demethylase inhibitor CPI-455, which also up-regulated H3K4me3 levels and increased cardiomyocyte generation. Single-cell RNA-seq data defined three cell branches, and knockout c-JUN activated more regulons that are related to cardiogenesis. In summary, our data demonstrated that c-JUN could regulate cardiomyocyte cell fate by modulating H3K4me3 modification and chromatin accessibility and shed light on how c-JUN regulates heart development in humans.
Fortalecimento da governança regional e da rede de atenção à saúde em municípios pequenos no Brasil
Authors: Silva João Felipe Marques da , Pantaleão Cristiane Martins , Santos Clodoaldo Fernandes dos , Leles Fernando Antônio Gomes , Rocha Karen Patrícia Wilke Pereira , Giacometti Luana Carla Tironi de Freitas , Terabe Sandro Haruyuki , Galiano Socorro Gross , Neto Valdeni Alexandre Ciconello
Published: August 2023

No Brasil, 67,7% dos municípios têm menos de 20 mil habitantes, sendo caracterizados como de pequeno porte. O objetivo do presente artigo é sistematizar a experiência e identificar os desafios e as lições aprendidas na implantação do modelo de fortalecimento da governança regional e da organização da rede de atenção à saúde (RAS) em uma região do Brasil composta por esses municípios, que apresentam baixa capacidade técnica e orçamentária, além de fragilidades diversas relacionadas à organização da RAS. Na perspectiva do fortalecimento da governança regional e da organização do processo de trabalho da atenção primária em saúde (APS) e, por consequência, dos fluxos com os outros níveis de atenção, foi proposta a estratégia intitulada Mais Cuidado Mais Saúde, desenvolvida em parceria com a Organização Pan-Americana da Saúde/Organização Mundial da Saúde (OPAS/OMS) e o Ministério da Saúde. O projeto foi executado por meio de processos de educação permanente em saúde e fortalecimento de capacidades institucionais na região de Ivaiporã/Paraná, com oficinas descentralizadas, contemplando três eixos prioritários: integração da RAS, formação de capacidades e gestão da informação. O público-alvo foram as equipes de APS ampliada. O projeto permitiu desenvolver capacidades locais e de governança regional por meio de reflexões conjuntas a respeito do modelo de atenção à saúde, de seus componentes e das mudanças necessárias nos processos de trabalho para a promoção de saúde com foco na qualidade de vida dos usuários. Por se tratar de uma experiência que considera as fragilidades, necessidades e autonomia dos atores locais, o projeto tem alto poder de replicação e customização para outras regiões com características similares dentro e fora do Brasil.
Государственное управление развитием здравоохранения
Authors: Полушкина Татьяна Михайловна , Шарикова Анастасия Григорьевна , Шлямов Артем Евгеньевич
Published: August 2023

Целью настоящей работы является разработка некоторых наиболее важных направлений по совершенствованию государственного управления здравоохранением региона. Это потребовало проведения анализа тенденций развития здравоохранения в исследуемом субъекте Российской Федерации – Республике Мордовия, их сравнения с другими регионами Приволжского федерального округа (далее ПФО), определения основных проблем в государственном регулировании развития здравоохранения на региональном уровне. Было определено место региона в рейтинге субъектов ПФО по эффективности управления системой здравоохранения.
ЭКОНОМИКА СТРОИТЕЛЬСТВА И ЭКСПЛУАТАЦИИ ЭНЕРГОЭФФЕКТИВНОГО ДОХОДНОГО ДОМА
Authors: Шагиахметова Эльвира Илшатовна , Матвеева Елена Сергеевна , Буркеев Данил Оскарович , Шайхутдинова Диана Ринатовна
Published: August 2023

Строительная индустрия во всем мире является одним из основных факторов истощения природных ресурсов и крупным потребителем энергии. В данной статье выполняется сравнительный анализ результатов экономической эффективности строительства и эксплуатации доходного энергоэффективного жилого дома при применении двух режимов налогообложения и при различной загрузке квартир в течение года. При проведении исследования были использованы методы: метод экспертного опроса на базе использования Google-форм, метод расчета чистого дисконтированного дохода (NPV), метод расчета дисконтированного срока окупаемости (PBP), метод расчета индекса рентабельности инвестиций (PI). Результаты исследования: проведенный опрос позволил выбрать оптимальный проект энергоэффективного доходного дома, для которого были рассчитаны показатели эффективности строительства и эксплуатации в течение 14 лет с учетом двух вариантов налогообложения и загрузки помещений в течение года. Выводы: расчеты показали, что использование льготного режима налогообложения позволит окупиться проекту даже при загрузке площадей в 57%. При этом для варианта с 70% загрузкой проект становится более оптимальным для реализации ввиду того, что срок окупаемости снижается на 3 года, а NPV за 14 лет эксплуатации становится больше на 18 783 тыс. руб. по сравнению с общим режимом налогообложения.
ТЕНДЕНЦИИ ФИНАНСИРОВАНИЯ СОЦИАЛЬНО-КУЛЬТУРНОЙ СФЕРЫ РЕГИОНА В НОВЫХ ЭКОНОМИЧЕСКИХ РЕАЛИЯХ
Authors: Такмазян Аида Самвеловна , Самойлова Карина Николаевна
Published: August 2023

Актуальность вопросов финансового обеспечения отраслей социально-культурного комплекса усиливается сохраняющимися условиями экономической неопределенности. Цель исследования – уточнить вектор развития государственной социальной политики субъектов Российской Федерации. В этой связи исследованы и выявлены тенденции финансирования таких отраслей социально-культурной сферы в Ростовской области, как социальная защита, здравоохранение, физкультура и спорт, образование, культура. Методология исследования. Проведенное исследование основано на методах научного познания экономических и социальных явлений.
АНАЛИЗ ИСПОЛЬЗОВАНИЯ ЗАТРАТ НА ИННОВАЦИОННУЮ ДЕЯТЕЛЬНОСТЬ И ПРОБЛЕМЫ ВНЕДРЕНИЯ ЭТОЙ ДЕЯТЕЛЬНОСТИ В СКФО И РД
Authors: Гасанов Гасан Атабабаевич , Гасанов Тофик Атабабаевич , Далгатова Изахат Далгатовна
Published: August 2023

Цель работы. В статье анализируются затраты на инновационную деятельность в РФ, СКФО и РД, по основным направлениям этой деятельности; сопоставляются удельные веса по видам затрат на инновационную деятельность, как в целом по России, так и по СКФО и РД. Цель статьи - выявить проблемы использования затрат на инновационную деятельность по основным направлениям их финансирования, для сбалансированного их распределения по видам этой деятельности, а также пути решения возникающих проблем в процессе их реализации с учетом специфики СКФО и РД. Методы и методология проведения работы. Методология исследования затрат на инновационную деятельность основывается на системном подходе, применяемых методов количественного и качественного анализа, прогнозирования, абстрактно-логического метода, статистических методов исследования показателей в области затрат на инновационную деятельность регионов, метод моделирования процессов. Результаты. В процессе анализа общих показателей инновационной деятельности в СКФО и РД было выявлено, что отдельные направления этой деятельности недостаточно обеспечены финансовыми средствами, а некоторые, причем важные, показатели вообще не финансировались как по РД, так и по отдельным субъектам СКФО. Такое положение дел в инновации объясняется тем, что в СКФО некоторые субъекты являются дотационными или депрессивными, поэтому развитие этих субъектов в области инновационной деятельности и других прогрессивных технологии зависит от поддержки из центра. Область применения результатов. Результаты проведенного исследования могут быть использованы при разработке инновационных программ в субъектах СКФО, в процессе преподавания по курсу «Инновационный менеджмент», «Методы управления инновационными проектами», «Инновация научных знаний», «Цифровая экономика». Выводы. Анализ затрат на инновационную деятельность, по СКФО и РД за 2021г. свидетельствует, что как в целом по региону, так и по РД затраты на эту деятельность явно не достаточно, для успешного развития региона и РД. Кроме того, по РД, также, как и по другим республикам СКФО, затраты по отдельным направлениям инновационной деятельности вообще не осуществляются, или эти затраты носят символический, показанной характер. Главная причина сложившегося положения дел в СКФО и РД – дотационный характер деятельности республики и некоторых субъектов СКФО. Именно поэтому происходит дисбаланс в затратах по основным направлениям инновационной деятельности.
RESEARCH ON THE MOTIVATION FOR CHOOSING THE TEACHING PROFESSION AND REASONS FOR LEAVING AMONG YOUNG TEACHERS
Authors:   Academy of Music, Dance and Fine Arts „Prof. Asen Diamandiev“, Plovdiv, Stoilova Liliya
Published: August 2023

This article examines the interrelationship between satisfaction with the choice of the teaching profession and the reasons for leaving the education system. The main reasons for leaving teachers (working conditions, organizational climate, administrative burden, etc.) are also examined. The research finds that people , who are satisfied with their choice of teaching profession, are less likely to leave school because of the workload, routine of the profession, poor student behavior, salary or heavy administrative burden. Peer support is also important for young teachers. This support can create a positive and empathetic work environment that supports motivation and job satisfaction. This creates a school community where teachers feel supported and important. In addition, peer support can encourage young teachers to participate in training, workshops and professional development. This improves the quality of their teaching practice and makes them more effective and competent in the school.
ON THE TECHNOLOGY OF IMPLEMENTING AN INTEGRATIVE APPROACH IN AN INNOVATIVE SCHOOL
Authors:   125th Secondary School „Boyan Penev“, Sofia, Stoyanova Petrova Stefana
Published: August 2023

The scholastic year 2022/2023 includes the final stage of the joint initiative of 125. Secondary School – Sofia and the Institute of Mathematics and Informatics at the BAS for the pilot implementation of an educational model for integrated learning in an innovative school. The technological scheme follows Altshuler’s TRIZ methodology. The article briefly describes the moments of the individual stages – specific problems and their solutions at the school level are presented. The results of the conducted research are analyzed. Identified are measures that should be taken by the teaching and management team of the school in order to move from the pilot implementation to regular pedagogical practice. Examples of project-oriented initiatives presented by students at school and regional forums are provided.
THE CONCEPT OF THE EDUCATIONAL MONTESSORI ENVIRONMENT – AN OPPORTUNITY TO ORGANIZE THE INDEPENDENT LEARNING OF ELEMENTARY SCHOOL STUDENTS
Authors:   Private Primary School „Dr. Maria Montessori“, Burgas, Dimitrova Bilyana
Published: August 2023

The article examines the philosophical and theoretical concept of the educational Montessori environment where the elementary school age students carry out active independent learning. Following already tried and proven effective principles for organizing and structuring the environment, the Montessori teacher in the elementary school has the most important responsibility – to build the educational space by creating autodidactic materials according to interests, needs, specifics of his students and the content of the curricula for general education subject in the elementary stage. He must connect the student with the environment in order to provoke his activity. Dr. Maria Montessori discovered that this is the way to create the best opportunities for independent learning, self-development, self-control and self-education. Keywords: Montessori environment, elementary school, independent learning, Montessori materials.
LEARNING IN MUSEUM – AN OPPORTUNITY FOR INTERACTIVITY IN PRESCHOOL AGE
Authors:   Kindergarten „Bratya Grimm“, Shumen, Mihova Evgeniya
Published: August 2023

The report presents a good example from the project activity of the „Brothers Grimm“ kindergarten in Shumen. At the beginning, the importance of learning outside the classroom is justified, the importance of the museum and the way of learning in preschool age is presented, as well as the importance of interactivity in this process. The essence of the project, the tasks it sets itself and the methodology are described. At the end, a summary of the results is made. In the course of work, various pedagogical concepts were presented, on the basis of which the team started and developed a model for interaction between kindergarten, museums and NGOs. A summary of the pedagogical significance of this experience is made.
FORMING HEALTH CULTURE IN ELEMENTARY SCHOOL STUDENTS
Authors:   New Bulgarian university, Sofia, Kostova Vanesa
Published: August 2023

Health culture is a competency which takes a leading role in European and national educational politics. In the European framework of the key competencies, health culture is a component of the personal and social competency, as it’s directed towards supporting one’s physical and emotional wellbeing, as well as keeping a good physical and mental health to lead an aware and future-focused life. In the national educational policy of Bulgaria, the formation of good health culture in students is regulated though the state educational standard – Ordinance No: 13 from 21.09.2016 for the citizen, health, ecological and intercultural education. The goal of this report is to analyse the educational content for forming heath culture and to showcase the appropriate methods to introduce health culture in the daily regime of elementary schools.
PROJECT-BASED LEARNING FOR DEVELOPMENT OF CREATIVE THINKIG, KEY SKILLS AND COMPETENCIES IN PRESCHOOL AGE
Authors:   Kindergarten Evropeicheta, Vratsa, Ilieva-Asenova Ina , Dancheva Valya ,   Kindergarten Evropeicheta, Vratsa
Published: August 2023

Dynamic changes in all areas of modern life also change the ways in which we learn and educate. We are increasingly required to think entrepreneurially, to have the ability to make independent decisions, to adapt in unfamiliar situations. Education meets these requirements through the application of new methods and technologies aimed at forming lifelong learning attitudes, for the acquisition of key competences laid down in the European Reference Framework. This report pay attention to the possibilities of project-based learning to achieve a new type of pedagogical interaction, to form key competences and to develop the creativity and imagination in the children. We share the activities approved in our own pedagogical practice under the „Design Champions“ program of the „Red paper plane“ organization. The program provides an opportunity to develop the skills of the XXI century, which are divided into functional literacy, competencies, character qualities. Emphasis is placed on how the project-based learning method and the principle of „learning by doing“ can be applied. The additional methods and techniques used support the achievement of knowledge and skills laid down in state educational standard for preschool education, create various inter-subject connections and form key competences needed by modern children and young people. The proposed technology helps not only to achieve better educational results for children of preschool age, but also to a higher quality of acquired knowledge and practical skills.
USE OF INNOVATIVE TECHNOLOGIES MEANS OF IMPROVING THE KINDERGARTEN EDUCATION
Authors:   Kindergarten „Zvunche“, Vratsa, Borisova Tsvetelina
Published: August 2023

Education is the backbone of each society. In a world, changing as fastly as nowadays, it is important that schools and kindergartens increase their efficiency. Modern children grow up in a technological world and teachers should work in a new way, which is interesting for the children, and which meets their needs. This makes the use of innovative methods and new technologies in the pedagogical process essential. Teachers should be able to provoke and maintain children’s interest by transforming situations from real life that are significant for the child, into lessons. That would not be possible without considering the individual characteristics and achievements of the children, as well as differing and/or individualizing the goals of pedagogical interaction. It is achieved by selecting different methods and techniques, and technology is just a valuable tool that makes these educational methods completed. It also helps both children and teachers. In the following research The article is presenting technological ways and means of teaching that contribute to a better teaching process in the kindergarten. They have been tested in practice for the past few years and they have proven themselves effective. The use of an Interactive Display, a Document-Camera, as well as the creation of games on the „Smart Kids“ platform gives the teacher the opportunity to diversify and enrich their work. As for the children, the digital devices are becoming tools for developing their creative potential. Digital devices also support children’s development and they stimulate their ability to make independent decisions.
LEGO GAMES AND THE MATHEMATICAL COMPETENCES OF FIVE-YEAR-OLD CHILDREN
Authors:   Kindergarten „Edinstvo Tvorchestvo Krasota“, Vratsa, Tosheva Ani , Mitrikova Yordanka ,   Kindergarten „Edinstvo Tvorchestvo Krasota“, Vratsa
Published: August 2023

The present report describes an innovative pedagogical practice related to the formation of mathematical competences in five-year-old children through the use of Lego games. The interdisciplinary approach teaches adolescents to apply their skills in the creation of a product /model/, which shows the inextricable connection between knowledge and a game situation related to real-world events. For this purpose, we took advantage of the educational sets „STEAM Park“, „Coding Express“ and the materials of LEGO Education. Applying the approaches „learning through playing“, „learning by doing“ and „learning from experience“ have a significant contribution to improve children’s skills in planning activities and working in small groups. During the process, children ask questions, propose solutions, try out ideas, gain experience. Lego games give them the opportunity to explore materials, make discoveries, test theories. Using the STEM approach in kindergarten ensures the development of critical thinking, communicative, creative and cooperative individuals prepared for the innovative professions of the future.
HOW TO INVOLVE CHILDREN IN THE WORLD OF NATURE? – GOOD PRACTICE
Authors:   Kindergarten „Druzhba“, Plovdiv, Mircheva Svetlana
Published: August 2023

We live in a time when more and more people pay attention to nature and are excited about environmental issues. Dirty air and polluted seas and rivers, the destruction of nature and the extinction of animal species are some of the serious problems. That is why it is important to teach children respect and love for nature from an early age. By applying project-based training from the first age group, the development of children’s cognitive habits is stimulated. This method of teaching allows active participation in real projects and turning educational situations into play.
SAMPLE TEACHER ASSISTANT TRAINING MODEL ON THE TOPIC: „THE ROLE OF THE TEACHER ASSISTANT IN OVERCOMING ANXIETY IN PRESCHOOL CHILDREN WHEN THEY ENTER KINDERGARTEN“
Authors:   Kindergarten „Zname na mira“, Vratsa, Stoyanova Diana
Published: August 2023

The considered model for organizing the intra-institutional qualification of assistant educators aims to make an attempt for optimal interaction of all participants in preschool education – children, teachers, assistant educators. A change in attitudes and ideas about the function and activities performed by assistant educators is sought. The qualification of assistant educators must be carried out with the same responsibility and awareness of its usefulness in order to achieve the expected effectiveness of the educational environment in kindergartens. The role and figure of the assistant educator has an important role in increasing the quality of care, upbringing and socialization of children in kindergarten, as a valuable resource and another adult who can create quality relationships with children.