bluuebunny/crossref_metadata_2025 huggingface dataset:
Antidiabetic drug profile of COVID-19 patients with comorbid diabetes mellitus
Authors: Hasmono Didik , Samirah Samirah , Gayatri Ni Putu Ayu Deviana , Ni’mawati Naning , Jaya Halim Prihayau , Triono Erwin Astha
Published: October 2023

Background:  Diabetes mellitus (DM) is a risk factor that can increase the severity and mortality of patients with COVID-19 infection. The use of antidiabetic drugs for diabetes mellitus patients with COVID-19 infection is very important to reduce these impacts.
Objective: This study aimed to determine the antidiabetic drug profiles of COVID-19 patients with comorbid diabetes mellitus.     
Method: This study was an analytic cross-sectional electronic medical record data of patients diagnosed with COVID-19 and comorbid Diabetes Mellitus. It was carried out from May until December 2020.     
Result: A total of 106 patients were involved and different types of antidiabetic drugs were used i.e., glimepiride in 32 patients (31.13%), metformin in 18 patients (16.98%), combination of long-acting and rapid-acting insulin in 20 patients (18.87%), and combination of metformin and glimepiride in 18 patients (16.98%).    
Conclusion: The most commonly prescribed single antidiabetic therapy in patients with COVID-19 and comorbid diabetes mellitus was glimepiride, followed by glimepiride and metformin. The most common insulin therapy combination was long-acting and rapid-acting insulin.
Effect of fondaparinux anticoagulants on D-dimer levels in Covid-19 patients
Authors: Putra Bella Donna Perdana , A.N.T Pratiwi Asih , Suprapti Budi , Arina Dery P , Sundari Mulya
Published: October 2023

Background: Anticoagulants can prevent thromboembolic activities, improve prognosis, and reduce the mortality rate in Covid-19 patients with coagulopathy.    
Objective: To analyse the effect of Fondaparinux in decreasing D-dimer levels, and to determine the correlation between patient characteristics, disease severity, and D-dimer levels.     
Methods: This is a single-centre retrospective cohort study using the medical records of Covid-19 in-patients who were ≥ 17 years old, on Fondaparinux 2.5 mg OD and had D-dimer measurement pre-and post-five days-Fondaparinux therapy during hospitalisation at referral general hospital in Bengkulu, Indonesia between April 2020 and December 2021. The data were assessed to evaluate the differences in the pre-post D-dimer levels, the relationship between patient characteristics and disease severity, and the relationship between disease severity and D-dimer levels.   
Results: A total of thirty-six patients were included in this study, of which 52.78% were males and 44.44% were aged 46-55 years old. Furthermore, 88.89% had comorbidity, and 55.55% had moderate severity. There was a significant decrease in D-dimer levels in all disease severity (p < 0.05). Patient characteristics and disease severity were not associated with D-dimer depletion (p > 0.05).     
Conclusion: Fondaparinux reduced the D-dimer levels in all severity of Covid-19 patients.
Activities of ethanol-extract of red ginger (Zingiber officinale var. Rubrum) on Completed Freund's Adjuvant-induced arthritis in mice
Authors: Fajrin Fifteen Aprila , Khasanah Putri Robiatul , Mikailla Yokta Esa , Holidah Diana , Dewi Ika Puspita
Published: October 2023

Background: Red ginger has been known to have anti-inflammatory and analgesic potency.     
Objective: This study aimed to analyse the ethanolic extract of red ginger (EERG) in mice's arthritis model induced by Completed Freund’s Adjuvant (CFA).     
Method: Red ginger was extracted using ethanol 96%. Arthritis mice (n = 25) were injected with CFA i.p., and sham mice (n = 5) were injected with normal saline. On day seven,  mice were divided into six groups: sham, CFA, gabapentin 100 mg/kg BW, and EERG (dose 200; 400; 600 mg/kg BW). Treatments were administered orally once a day for seven days. Latency time and plantar thickness were measured on days zero, one, three, five, seven, eight, ten, twelve, and fourteen. On day 15, the mice were sacrificed, and the blood and spinal cords were collected. The haematology profiles were determined.    
Result: The EERG significantly prolonged the latency time towards thermal stimulus and decreased plantar thickness in arthritis mice, the same as gabapentin which served as the control. The EERG also reduced the number of leukocytes, lymphocytes, and neutrophils, and improved the morphology of the spinal cord's dorsal horn of arthritis mice.    
Conclusion: The EERG of 400 mg/kg BW significantly affects arthritis-induced hyperalgesia.
Regulations of the distribution of pharmaceutical services (pharmacies) locations in Indonesia: A review
Authors: Catur Dian Setiawan  , Wibowo Arief , Athiyah Umi
Published: October 2023

Background: Regulations for managing the distribution of pharmacies have been established in several countries, including Indonesia. The guidelines for establishing pharmacies have been published at some levels of government. However, the location of pharmacies in Indonesia is still uneven.
Objective: to observe the regulations for determining the location of pharmacies in Indonesia   
Method: This paper documents several rules issued by the government, food and drug regulatory agencies, and pharmacists’ professional organisations that are related to the distribution of pharmacies in Indonesia.
Result: There were no specific regulations governing the location of pharmacy distribution in Indonesia. Elaboration of laws about location distribution only regulates environmental waste management.
Conclusion: The three factors that make it possible to improve the accessibility of pharmacies in Indonesia are 1) regulation of pharmacy ownership; 2) space between pharmacies; and 3) incentives for pharmacies in remote areas
Assessment of the phytochemicals and anthelminthic activities of Adiantum raddianum and Kibatalia arborea extracts
Authors: Ghita Yogisuari  , Rocky Fahriar Reza  , Lailia Nur Rachma  , Tri Yudani Mardining Raras  , Antonius Nugraha Widhi Pratama  , Ari Satia Nugraha  , Bawon Triatmoko
Published: October 2023

Background: A limited spectrum and inappropriate use of anthelmintics lead to anthelmintic resistance. Among Indonesian medicinal plants, Adiantum raddianum (Suplir) and Kibatalia arborea (Jelutong Pipit) have shown antihelmintic properties.
Objective: To reveal the anthelmintic activity as preliminary screening of A. raddianum and K. arborea leaves.
Method: This study used the antihelmintic microdilution test towards methanol extracts at 500 µg/mL. The mortality of Caenorhabditis elegans expresses the presence of anthelmintic activity. Phytochemical screening was determined using thin-layer chromatography.
Result: The methanol extracts of both extracts had anthelmintic activity with mortality values of 14.941% and 15.134%, respectively. Both extracts contain polyphenols, flavonoids, terpenoids, and alkaloids found only in K. arborea. 
Conclusion: This study reveals that the methanol extract of A. raddianum and K. arborea leaves have anthelmintic activity, which could be related to the findings of phytochemical constituents.
Terpenoids from Euphorbiaceae as a source of antimalarial medicines: A literature review
Authors: Ekasari Wiwied , Mahardiani Anisah , Putri Nindya Tresiana
Published: October 2023

Background: Malaria is an infectious disease caused by the Plasmodium parasite and transmitted by the Anopheles mosquito. Plasmodium falciparum is a parasite that causes the most deaths. Currently, there is resistance to various antimalarial drugs. For this reason, it is necessary to search for new antimalarial agents. Medicinal plants have been shown to play an important role in treating malaria for thousands of years. Some of Euphorbiaceae family plants contains terpenoid compounds, which are compounds with antimalarial activity.
Objective: The present review aims to provide an overview of the terpenoid compounds from Euphorbiaceae family as an antimalarial.
Method: Comprehensive information on Euphorbiaceae family from 2002-2022 was searched for literature relevant to major science-based data, including Scopus, Science, ScienceDirect, Pubmed, and SciFinder, using appropriate keyword combinations.
Result: A total of 15 papers were included in this review. The terpenoids isolated from 14 species of Euphorbiaceae family and reported to possess antimalarial activity are presented.
Conclusion: Terpenoids are found in almost all parts of Euphorbiaceae family plants and are reported to have moderate to high antimalarial activity.  Screening of antimalarial terpenoid activity in Ephorbiaceae family plants can be a key step in the source and development of new antimalarial drugs.
An analysis of the Michaelis-Menten pharmacokinetics of phenytoin in epileptic Indonesian adults
Authors: Sumarno  , Kurnia Kusumastuti  , Junaidi Khotib
Published: October 2023

Background: Phenytoin metabolism has been shown to vary in different ethnic groups. Therefore, the authors studied phenytoin pharmacokinetics in Indonesian adult patients with epilepsy.
Objective: The purpose of this study was to determine and analyse the pharmacokinetic parameters of Michaelis Menten Vmax (maximum velocity) and Km (the Michaelis constant) of phenytoin in adult epileptic patients.
Method: Twelve adult epileptic patients were chosen on the basis that they had two reliable steady-state phenytoin serum levels at two different daily doses and they required an additional adjustment of phenytoin dosage monotherapy.
Result: The Vmax and Km values for adult epileptic patients respectively, ranged from 3.78 to 9.65 mg/kg/day and from 0.71 to 5.58 mg/L and there was no correlation with age and weight (p > 0.05). The Vmax and Km values have shown individual variability.
Conclusion:  The optimal adjustment of phenytoin dose individually in adult epileptic patients based on Vmax and Km parameters needs to be done to get the desired steady-state level according to the clinical response.
The relationship of body mass index and T score in healthy and knee osteoarthritis women
Authors: Achmad Anisyah , Suharjono  , Soeroso Joewono , Suprapti Budi , Siswandono  , Pristianty Liza , Rahmadi Mahardian , Nugraha Jusak , Surya Yoki , Isma Satria Pandu Persada , Rahadiansyah Erreza , Fahmi Ilmia , Wilujeng Catur Saptaning
Published: October 2023

Background: Osteoarthritis (OA) is a chronic, degenerative, slowly progressive disease common in women with multiple aetiology. Osteoarthritis occurs simultaneously with the reduction in bone mineral density (BMD)while a high bone mass index (BMI) value is one of the risk factors for OA.
Objective: The purpose of this study was to determine the effect of BMI and BMD in healthy and knee OA women.
Method: The study was conducted in an orthopaedic outpatient clinic in 2021. This is a quantitative descriptive study with accidental cross-sectional samplings. The Mann-Whitney test was used to analyse the data.
Result: Subjects included in the inclusion criteria obtained 74 OA and 49 control groups. The largest subjects in the OA group were aged 56-65 years old  (32, 43.24%), obese (51, 68.92%), and post-menopause (49, 66.22%). At the same time, the T score category was normal (14, 18.91%), osteopenia (22, 29.73%), and osteoporosis (38, 51.35%). Statistical analysis found a significant relationship between BMI and BMD (p = 0.002, p = 0.001) in controls and OA groups.
Conclusion: Disorders of BMI and BMD are indicators of risk for OA. High BMI and low BMD values occur in women with knee OA. There is a relationship between BMI and BMD in healthy and knee OA women.
Profile of the management of pharmaceutical products and medical consumables at primary healthcare centres in North Toraja district
Authors: Impa Elson , Nita Yunita , Priyandani Yuni
Published: October 2023

Background: The management of pharmaceutical products and medical consumables in primary healthcare centres (PHCs)should be efficient, effective, and rational. Management is one of the competencies of pharmacists.
Objective: This study aimed to describe the management profile of pharmaceutical products and medical consumables at primary healthcare centres in the North Toraja district.
Method: This cross-sectional study used a questionnaire to collect data. The indicator for managing pharmaceutical products and medical consumables was based on technical guidelines for pharmaceutical service standards at primary healthcare centres issued by the Ministry of Health of the Republic of Indonesia in 2019. Research variables were planning, procurement, receipt, storage, distribution, disposal and recall, control, and administration. The sample consisted of all 28 PHCs in the North Toraja district. 
Results: The results from 27 PHCs showed that the management of pharmaceutical products and medical consumables consisted of planning (72.62%), procurement (66.06%), receipt (83.07%), storage (61.47%), distribution (66.69%), disposal and recall (33.84%), control (56.74%), and administration (62.36%).
Conclusion: Managing pharmaceutical products and medical consumables at PHCs in the North Toraja district did not fully comply with pharmaceutical service standards.
Meloxicam self-nano-emulsifying drug delivery system with surfactants combination: Formulation and in vitro release model
Authors: Putri Salsabila Ayundiva , Winarti Lina
Published: October 2023

Background: Meloxicam has low water solubility, which affects the dissolution and level of absorption.
Objective: The study aimed to develop a self-nano-emulsifying drug delivery system (SNEDDS) based on a non-ionic surfactant combination and evaluate the release kinetics model using the DDsolver program.
Methods: Oil, surfactant, and co-surfactant were selected based on the solubility of meloxicam.
Results: The best formula showed that 10% of castor oil, 70% of surfactant (tween 80: chromophore RH 40 in 1:1), and 20% of PEG 400 could develop SNEDDS with the 99.84±0.04% percentage of transmittance, 15.47±0.72 sec emulsifying time, and below 50 nm droplet size. The optimised formula is also stable and resistant to various dilutions and pH The dissolution efficiency (DE0-60) reveals a 5.27-fold increase compared to non-SNEDDS meloxicam. Meloxicam follows Korsmeyer-Peppas release kinetics, while meloxicam SNEDDS follows the Hixon-Crowell model.
Conclusion: The best formula of SNEDDS consisting of a surfactant combination generate improvement in vitro dissolution of meloxicam.
Effect of Allopurinol administration on the uric acid level and kidney function in paediatrics with tumour lysis syndrome (TLS) and high-risk TLS
Authors: Yulistiani  , Kharismawati Indira Dhany , Ugrasena I Dewa Gede , Qibtiyah Mariyatul
Published: October 2023

Background: Tumor lysis syndrome (TLS) is a life-threatening oncologic emergency because of the release of tumour cell components such as uric acid, which can lead to hyperuricemia and acute kidney injury (AKI).
Objective:  To analyse serum uric acid, creatinine, and BUN levels pre- and post-allopurinol administration.
Method: This study was a prospective observational study conducted from March to July 2020. Inclusion criteria were haematological malignancies in paediatric patients with TLS and high-risk TLS who received allopurinol 10 mg/kg/day in 2-3 divided doses. Collected data were the serum uric acid, creatinine, and BUN levels pre- and post-allopurinol administration.
Result: There were 14 sample in total during the study. There was a significant difference in uric acid level on day six after allopurinol administration compared to baseline in patients with high-risk TLS (p < 0.05).
Conclusion: Allopurinol was inadequate in reducing uric acid levels in TLS patients but adequate in reducing uric acid levels in patients with high-risk TLS.
Role of work engagement in behavioural intention to use electronic medical records: A cross-sectional study
Authors: Faida Eka Wilda , Wahyuni Titin , Sutha Diah Wijayanti , Muhadi  , Elisanti Alinea Dwi
Published: October 2023

Background: In this era of a rapidly advancing technological landscape, the Electronic Medical Record (EMR) has increased the awareness of health services on the importance of the roles of workers in utilising information technology.     
Objective: To analyse the factors influencing behavioural intention in the EMR system by adding the work engagement factor as an exogenous variable based on the Unified Theory of Acceptance and Use of Technology (UTAUT) theoretical framework.    
Method: This cross-sectional study enrolled a sample of 195 participants from a population of 390 medical students. Data analysis used structural models with multivariate structural equation modelling.      
Results: Facilitating conditions (t-statistic=3.154; p=0.0001), performance expectancy (t-statistic=2.983, p=0.003), and work engagement (t-statistic=4.998, p=0.0001) had an effect on the behavioural intention, while effort expectancy (t-statistic=0.779, p=0.436) and social influence (t-statistic=0.266, p=0.790) did not affect the behavioural intention.    
Conclusion: Performance expectancy, facilitating conditions, and work engagement could affect behavioural intention by R²=74%. Work engagement had the strongest effect among other exogenous variables.
Şanlıurfa İlindeki İşletmelerin Ar-Ge, Teknokent, Mentörlük ve Danışmanlık Hizmetlerine Yaklaşımlarının Araştırılması
Authors: SARIIŞIK Gencay , ÖĞÜTLÜ Ahmet Sabri
Published: October 2023

Bu çalışmada; Şanlıurfa ilinde faaliyet gösteren işletmelerin Ar-Ge, Teknokent, Mentörlük ve Danışmanlık hizmetlerine yaklaşımlarının belirlenmesi amaçlanmıştır. Şanlıurfa ilinde tekstil, gıda, kimya, elektrik-elektronik ve makine sektörlerinde faaliyet gösteren yüz yirmi (120) işletmenin sekiz soru ile görüşleri alınmıştır. İşletmelerin Ar-Ge yaklaşımlarında beş hipotez, Teknokent, Mentörlük ve Danışmanlık hizmetleri yaklaşımında üç hipotez Ki-kare testi ile test edilerek, sektörel farklılıkları belirlenmiştir. İşletmelerin Ar-Ge yaklaşımları düşük seviyede iken Teknokent, Mentörlük ve Danışmanlık hizmeti yaklaşımları yüksek düzeyde olduğu tespit edilmiştir. İşletmelerin AR-GE çalışmaları, ürün geliştirme, teknolojik destek vb. konularda Üniversite ile işbirliği kurma isteği yaklaşık % 62 olması bu konuda işletmeler ile işbirliğinin artırılması gerektiğini ortaya koymuştur. Ayrıca işletmelerin danışmanlık ve benzeri destek faaliyetlerini Teknokent üzerinden alma isteğinin yaklaşık % 78 olması yine Üniversite işbirliğinin arttırılması gerekliliğini göstermiştir.
Fatores motivacionais e diferenças presentes na prática do futsal entre jovens atletas
Authors: Neves Nathan Campos , Freitas Tatiane Cristina Rodrigues de , Caríssimo João Marcelo Niquini , Silva César Milagres da , Silva Siomara Aparecida da
Published: October 2023

O estudo teve como objetivo investigar os principais motivos que levam crianças e jovens à permanência na prática de futsal. Como instrumento de coleta de dados, foi utilizado o Inventário de Motivação a Prática de Atividade Física (IMPRAF-54) composta por seis dimensões: controle do estresse, saúde, sociabilidade, competitividade, estética e prazer. Este foi respondido por 122 jogadores de futsal, de ambos os sexos, participantes de um projeto social no estado do Paraná. A análise estatística se valeu do teste de Kruskal-Wallis com post hoc Bonferroni para comparação entre as categorias de base. Os fatores motivacionais mais considerados pelos jovens jogadores são os relacionados a Saúde e Prazer, enquanto Controle do Estresse e Estética foram as dimensões menos atribuídas por eles. A partir dos resultados obtidos, é possível que os profissionais atuantes nesses espaços reavaliem as suas práticas e criem estratégias com base os próprios interesses e necessidades dos praticantes, a fim de evitar/diminuir a evasão ao longo prazo.
Algorithms and web servers for protein binding sites detection in drug discovery
Authors:   National Institute of Chemistry, Theory Department, Ljubljana, Slovenia, Konc Janez , Janežič Dušanka ,   University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies, Slovenia
Published: October 2023

Drug discovery is a protracted and demanding process, which can be expedited during its early stages through novel mathematical approaches and modern computing. To tackle this crucial issue, we are developing fresh mathematical solutions aimed at detecting and characterizing protein binding sites, pivotal for new drug discovery. This paper introduces algorithms founded on graph theory which we have devised to scrutinize target biological proteins. These algorithms yield vital data, facilitating the optimization of initial phases in novel drug development. A particular emphasis lies in the creation of pioneering protein binding site prediction algorithms (ProBiS) and innovative web tools for modeling pharmaceutically intriguing molecules—ProBiS tools. These tools have matured into comprehensive graphical resources for the study of proteins in the proteome. ProBiS stands apart from other structural algorithms due to its ability to align proteins with disparate folds, all without prior knowledge of the binding sites. This unique capability enables the identification of analogous binding sites and the prediction of molecular ligands of diverse pharmaceutical relevance. These ligands could potentially progress into drug candidates for treating diseases. Notably, this prediction is based on data sourced from the complete Protein Data Bank (PDB) and the AlphaFold database, encompassing proteins not yet cataloged in the PDB. All ProBiS tools are made available without charge to the academic community through http://insilab.org and https://probis.nih.gov.
IRM@Be2+ – quantum chemistry between Bavaria and Šumadija
Authors:   Friedrich-Alexander Universität Erlangen-Nürnberg, Department Chemie und Pharmazie, Germany, Puchta Ralph , Ćoćić Dušan ,   2 University of Kragujevac, Faculty of Science, Serbia
Published: October 2023

Quantum chemical (density functional theory) mechanistic investigations on ligand exchange reactions at a tetrahedrally-coordinated dicationic Beryllium center offer a harmless and alternative way to learn about the traversed reaction pathways compared to experimental studies. Calculations for solvent exchange at [Be(H2O)4]2+, [Be(NH3)]2+, and [Be(HCN)4]2+ showed interchange (I) type mechanisms. To learn about the potential influences of spectator ligands we calculated the water exchange at [Be(L)(H2O)3]n+ (L: neutral ligands, mono-anionic ligands or cationic ligands) and got again consequently I-type paths. The activation energies depend strongly on the starting complexes, e.g., if hydrogen bonds have to be broken. The influence of spectator ligands is limited to the charge of the ligand and therefore the overall charge of the beryllium complex. The small size of the beryllium solvent complexes allows to test tools like AIM to dissect between pure interchange mechanisms, associative mechanisms and dissociative interchange mechanisms based on electron density along the reaction pathway.
Система социальной и культурной адаптации и интеграции
иностранных граждан в российское общество:
анализ опыта вузов Российской Федерации
Authors: Калинникова Лариса Николаевна
Published: October 2023

Проведен анализ технологии взаимодействия иностранных граждан, обучающихся в вузах Рос-сийской Федерации, и штата учебных заведений в лице администрации, профессорско-преподавательского коллектива, студенческого сообщества. Установлены критерии, необходи-мые для конструктивного взаимодействия между иностранными гражданами и принимающим сообществом, определены условия для формирования системы социальной и культурной адап-тации иностранных студентов и их интеграции в российское общество посредством интеграции в академическое сообщество.
ANALYSIS OF THE EFFECTIVENESS OF PATHOGENETIC PHARMACOTHERAPY FOR SPINAL MUSCULAR ATROPHY IN CHILDREN IN THE CHUVASH REPUBLIC
Authors: Pavlova Svetlana I. , Prokopeva Vitalina R. , Milova Oksana I. , Pavlov Anatolii A.
Published: October 2023

Since 2020, pathogenetic pharmacotherapy of spinal muscular atrophy in children has been introduced into use in the Chuvash Republic. To date, the results of more than two years of using Nusinersen and Risdiplam have been accumulated. The aim of the study was to generalize the experience of pathogenetic pharmacotherapy for spinal muscular atrophy with an assessment of the factors determining its effectiveness in children in the Chuvash Republic. Materials and methods. A retrospective analysis of medical records of 15 inpatient patients with spinal muscular atrophy who were treated in the settings of the neuropsychiatric department of the Republican Children's Clinical Hospital under the Health Ministry of Chuvashia for the period from 2020 to May 2023 was carried out. The effectiveness of therapy was evaluated using clinical scales for assessing motor functions recommended for patients with spinal muscular atrophy. Study results. In the group of patients with severe manifestations (type I spinal muscular atrophy), clinical improvements in motor functions during treatment were observed in 50%, there was no positive dynamics in 30%, deterioration was registered in 20%. Attention should be paid to the fact that at the early start of therapy (up to 6 months after the disease manifestation), at least a slight increase in motor functions was observed in 100% of patients. On the other hand, the effectiveness of Nusinersen and/ or Risdiplam was observed in none of the patients with type I or II spinal muscular atrophy at late therapy, but these patients also repeatedly observed deterioration of motor functions. During the period of observing the children, even when the facts of improvement in motor function in points were established, swallowing disorders and respiratory failure often progressed, which required probe feeding and continued artificial pulmonary ventilation. At this, no facts of developing undesirable adverse reactions to medications were noted. Conclusions. The analysis of pharmacotherapy with Nusinersen and Risdiplam in children with spinal muscular atrophy in the Chuvash Republic indicates a better effect of pathogenetic therapy at its early onset and a lower initial severity of the disease. It should be noted that there was no significant improvement in the quality of life in any of the cases. In addition, in order to effectively use these drugs, objective methods should be developed to assess the survival of motor neurons and the quality of life, as well as to recommend the timing of pathogenetic therapy initiation.
CYTOMORPHOLOGICAL STRUCTURE OF THE GREATER OMENTUM IN BORDERLINE OVARIAN TUMOR
Authors: Gozman Elena S.
Published: October 2023

The article describes the cytomorphological organization of the greater omentum in borderline ovarian tumor. The cytomorphology of the greater omentum in this pathology has not been studied enough, so this work is of scientific interest, and the topic under study is relevant. The aim of the research was to study the structural organization of the greater omentum in borderline ovarian tumor. Materials and methods. Information on the cytomorphological structure of the main parts of the greater omentum was studied, described and analyzed. These include adipose, lymphoid and epithelial tissue. The cytomorphological structure features of the greater omentum were studied in 20 patients who were treated for borderline ovarian tumor. Study results. The studied preparations of greater omentaries demonstrate a normal structure of this organ without manifestations of pathological signs or other specific changes. The adipoid and loose connective tissue in the greater omentum is well expressed, and the vascular system of the organ is also developed. Lymphoid structures are found in large numbers. They are responsible for implementing immune protection and thus can restrain dissemination of atypical cells and prevent their spread. Conclusions. In borderline ovarian tumor, the greater omentum is an organ that prevents the progression of the disease and reduces the likelihood of its recurrence. It is necessary to accurately determine the histological type of tumor intraoperatively in order to avoid omentectomy in case of suspected malignancy of the tumor.
THE EFFECT OF DRY WHITE MISTLETOE EXTRACT ON THE CHANGE IN THE RATIO OF MITOCHONDRIAL SUBPOPULATIONS IN THE MYOCARDIUM IN ANIMALS WITH ALCOHOLIC CARDIOMYOPATHY
Authors: Pozdnyakov Dmitriy I. , Vichor’ Anastasia A. , Adjiachmetova Similla L.
Published: October 2023

The aim of the research was to study the cardioprotective effect of dry white mistletoe extract in the context of assessing its effect on changes in the activity of interfibrillary and subsarcolemmal mitochondrial subpopulations of the myocardium in experimental alcoholic cardiomyopathy. Materials and methods. Alcoholic cardiomyopathy was modeled in female Wistar rats by course administration of ethanol at the rate of 3 g of absolute ethanol per 1 kg of animal body weight. The studied extract of white mistletoe leaves and the comparison drug – Trimetazidine – were administered orally at doses of 100 mg /kg and 35 mg/kg, respectively. Changes in troponin I concentration and serum creatine phosphokinase activity, citrate synthase activity in mitochondrial subpopulations, and the content of apoptosis markers – apoptosis-inducing factor and caspase 3 in myocardial tissue homogenate were determined during the work. Results and their discussion. The analysis of the results revealed that in rats with alcoholic cardiomyopathy, but without treatment, there is an increase in the concentration of troponin I and creatine phosphokinase activity, accompanied by an increase in the intensity of apoptosis reactions and citrate synthase activity of interfibrillary mitochondria. The use of Trimetazidine and the extract under analysis contributed to a decrease in troponin I content by 19.1% (p < 0.05) and 24.4%, respectively, and creatine phosphokinase activity by 19.8% (p < 0.05) and 28.4% (p < 0.05). It was also established that the activity of subsarcolemmal mitochondria in animals treated with Trimetazidine and white mistletoe extract increased by 121.9% (p < 0.05) and 306.3% (p < 0.05) with a decrease in the activity of citrate synthase of interfibrillary mitochondria by 27.6% (p < 0.05) and 41.4% (p < 0.05). It should be noted that administration of the comparative drug and the studied extract to rats resulted in a decrease in cardiomyocytes' apoptosis, expressed in a decrease in the concentration of apoptosis-inducing factor and caspase 3. Conclusions. In conditions of alcoholic cardiomyopathy, the negative interfibrillary phenotype of mitochondria prevails, which can contribute to the development of energy deficiency in the heart muscle, increasing the degree of myocardial damage. Based on the data obtained, it can be assumed that the extract of white mistletoe contains an active substance of cardioprotective activity associated with restoring the energy metabolism and suppression of apoptosis in the myocardium.
INTERRELATION OF BUDGET RISKS AND RISKS OF SOCIO-ECONOMIC DEVELOPMENT OF MUNICIPALITY
Authors: Arkadeva Olga G. , Berezina Natalia V. , Grigoreva Tatyana A.
Published: October 2023

The purpose of this study is to analyze the relationship between budgetary risks and the risks of socio-economic development of the municipality, identifying the features of risk management in the metropolitan urban district. Materials and methods. The main research method was the coefficient analysis of risks, based on the dynamic and spatial comparison of a number of indicators of socio-economic development and statistical assessment of budget execution in terms of revenues and expenditures. The main sources of data were information published by the territorial bodies of the Federal State Statistics Service and the administrations of the relevant municipalities. Results. According to the results of the calculations, it turned out that the republics of Chuvashia and Tatarstan are developing under the influence of growing urbanization. However, the city of Kazan concentrates the economic potential of the region to a lesser extent than the city of Cheboksary, and wages in the Republic of Tatarstan are less differentiated between the capital and the periphery than in Chuvashia. A higher concentration of certain groups of risks in Kazan (financial, social) is accompanied by a more effective policy of regulating economic development and the rhythm of fulfilling social obligations of the budget. Conclusions. It has been established that the focus on raising funds from the higher budget has a positive effect on the quality of financial discipline in the municipality, but since this situation is caused by the relatively low economic potential of the territory, the effect of the redistribution of resources, expressed in the level of economic activity, providing the population with public goods is low, and the relatively low risks of socio-economic development are due to the lower intensity of reproductive and demographic processes.
IMPACT OF SANCTIONS FOR THE DEVELOPMENT OF OIL PRODUCING COUNTRIES
Authors: Arkadeva Olga G. , Petrova Mariya A.
Published: October 2023

In the context of a growing shortage of financial resources and a change in priorities in the distribution of budgetary resources, the issues of managing the balance of the consolidated budgets of the Russian regions are of particular relevance. The purpose of this study is to analyze the formation of the financial result of the execution of the consolidated budgets of Russian regions during periods of economic recession and recovery, as well as to highlight the negative and positive aspects of the formation of the regional budget deficit. Materials and methods. The main research method was a retrospective analysis of the formation of the financial result of the execution of the consolidated budgets of Russian regions. Results. The article studies the negative and positive causes of the budget deficit, analyzes the dynamics of the financial result of the execution of the consolidated budgets of the subjects of the Russian Federation for the period 2013-2022; the dynamics of the aggregated deficit (surplus) of the budgets of Russian regions is considered; the features of the formation of the financial result of the execution of the budget of donor regions and subsidized regions are studied. Conclusions. A budget deficit is not always a negative phenomenon, as it may indicate that the budget is increasing spending on education, healthcare, social policy, stimulating and supporting business development, which leads to an increase in the quality of life in the region and an improvement in social – economic situation. Each region can potentially face a budget deficit as a result of its cash execution during the economic downturn, and most often the budget deficit reflects the crisis in the country's economy, as the regions' own incomes decrease and expenses increase significantly. During the crisis, not only subsidized regions, but also donor regions face a budget deficit.
DEVELOPMENT OF FACTORING OPERATIONS IN THE RUSSIAN MARKET
Authors: Kazanskaya Natalia N. , Zinovieva Lyudmila K.
Published: October 2023

The purpose of this study is to assess the level and prospects of factoring development in Russia based on the study of the regulatory framework and key indicators of the Russian factoring market. Materials and methods. The main methods were a comparative analysis of the indicators of the development of the factoring market in the regions of Russia and a retrospective analysis of the total factoring portfolio in the conditions of the Russian economy. Results. Within the framework of this study, the regulatory framework regulating factoring operations is analyzed. The varieties of factoring have been studied and grouped according to the corresponding characteristics. The analysis of key indicators of the Russian factoring market is carried out. As a result, their changes in dynamics are revealed. Analysis of the structure of the factoring portfolio allows us to conclude that the share of assets under contracts without recourse is increasing, which is understandable, since suppliers in a crisis period try to avoid the risk of default of the buyer. Also, the analysis allowed us to state that the main factoring transactions were made between suppliers and buyers from Russia. In addition, geographical features of factoring development in the Russian market are analyzed. It was revealed that it was most widespread in Moscow, the Central and Ural Federal Districts. The varieties of digital platforms for factoring operations have been studied. A comparative analysis of the quality of functioning of online factoring platforms in the Russian market is carried out. Conclusions. The Russian factoring market can be called very promising from the point of view of development within the regions of Russia. Moreover, there is a formation of the factoring market using mainly contracts without recourse. It was also revealed that the largest players in this market are subsidiaries of large domestic banks. This trend will continue in the near future in accordance with the specifics of the Russian factoring market. In addition, the prospects for the development of this market include the active development of online factoring platforms.
Transurethral Resection of Prostate (TURP) Through The Decades – A Comparison of Results Over the Last Thirty Years in a Single Institution in Asia
Authors: Lim KB , Wong MYC , Foo KT
Published: October 2023

Introduction: This study was conducted to evaluate the results and complications of transurethral resection of prostate (TURP) over the last 30 years in our institution.

Materials and Methods: This retrospective study encompasses 3 different eras: 168 patients in the late 70s, 175 patients in the late 80s and 283 patients in the late 90s. All the patients had at least 18 months of follow-up.

Results: The mean age from the 1970s, the 1980s and 1999 were 68.8 years, 69.2 years and 69.4 years respectively. The proportion of patients operated on for acute retention fell from 78.6% (132) in the 1970s, to 54% (96) in the 1980s, and 43% (122) in 1999. The mean resection time was 44.8 minutes in 1989 and 41.8 minutes in 1999. The mean weight of prostate resected was 22.1 g in the 1970s, 24.2 g in 1989 and 22.2 g in 1999. 44% (74) required blood transfusion in the 1970s, with 11% (19) in 1989 and 4% (11) in 1999. There were 2 deaths (acute myocardial infarction and pneumonia) in the 1970s, 1 (pneumonia) in 1989 and no mortality in 1999. There were 4 patients with TURP syndrome in the 1970s, 3 in 1989 and 1 in 1999. The incidence of postoperative urinary tract infection (UTI) was 25% (42) in the 1970s, 16% (29) in 1989 and 6% (17) in 1999.

Conclusions: As expertise and experience in TURP progress, the complication rates fall, as evidenced by the lower rates of transfusion, TURP syndrome and postoperative UTI in the later series.
CHARACTERIZATION OF THE RAMON TREE SEED (Brosimum alicastrum Swartz.) AS A POTENTIAL FOOD SOURCE
Authors: Trujillo-Nava Itzel J. , Negrete-Hernández José , García-Arrazola Roeb , Dávila Úrsula , Gimeno Miquel
Published: October 2023

The main objective of this work was to study the physical, chemical, and functional properties of the seed of the Ramon tree (Brosimum alicastrum Swartz) to evaluate its potential application in the elaboration of food products of high nutritional value. The results were compared with other seeds marketed internationally through an a posteriori comparative study of means. Ramon seed yielded 43.99 % of the dietary fiber, with energy value of 183.02 kcal per 100 g seed, cation exchange of 0.0015 meq [H+] g-1 seed, and uptake of organic molecules of 0.91 g oil g-1 seed. Trolox equivalent antioxidant capacity had a value of 0.88 mg Trolox g-1 of seed. The antioxidant activity of the seed (IC50) was 1.602 mg mL-1, while the tree leaf had an IC50 of 0.618 mg mL-1. The content of total phenols and flavonoids was also determined, resulting in 154 mg of gallic acid per 100 g of seed and 72.14 mg of catechin per 100 g of seed, respectively. To evaluate its capacity to produce high-nutritional-value foods, the biscuit test was carried out with Ramon seed whole meal flour, obtaining an expansion factor of 62.8. All the aforementioned tests were performed in triplicate, and the Student’s t-test was used for the comparison of means between treatments. The hypothesis of the present work was demonstrated since the seed of the Ramon tree represents an alternative as a functional food, since physical, chemical, and functional properties comparable to other seeds of recognized nutritional value were observed.
Gas Compressibility Factor Prediction Using Machining Learning Algorithmic Protocol for Niger – Delta Gas Reservoir
Authors:   Petroleum and Gas Engineering University of Port Harcourt, Rivers, Nigeria., Francis Anadu , Irene Mbachu Ijeoma ,   Petroleum and Gas Engineering University of Port Harcourt, Rivers, Nigeria.
Published: October 2023

The gas compressibility factor also known as Z-factor plays an important role in obtaining thermodynamic properties of natural gas reservoir fluid property. Typically, empirical correlations and complex equation of state have been applied to determine this parameter in absence of laboratory measurements. However, high cost of running experimental measurement, poor performance and some limitations associated with these existing correlations have made the researchers to use intelligent models instead. Therefore, this study aimed at adopting support vector machine algorithm to forecast gas compressibility factor and to validate its performance with predictions from Artificial Neural network (ANN) and some existing correlations using statistical and performance plot analysis. A total of 519 data sets from Niger Delta was used in developing the model, out of it, 70 percent was used for training, 20 percent for testing and 10 percent for validation using MATLAB tool. From the statistical analysis result, it was observed that the new developed model did better than other existing methods with numerical value of 0.1997 rank, 0.0009 mean absolute error and 0.98 of coefficient of correlation using the test data. The cross plot of the support vector machine model gave the tightest cloud along 45o reference line. The residual (error) associated with the performance was impressive which was done to observe the distribution and the interval at which the error is minimal.
The Role of Digital Marketing and New Students' Trust to Opt for Darma Agung University
Authors:   Faculty of Economics and Business, Darma Agung University, Medan, Indonesia, Ria Chainar Elly , Napitupulu Runggu Besmandala ,   Faculty of Economics and Business, Darma Agung University, Medan, Indonesia, Tarigan Jenni ,   Faculty of Economics and Business, Darma Agung University, Medan, Indonesia
Published: October 2023

This research aims to discuss the influence of digital marketing and the new students’s trust in the decision to opt for Darma Agung University (UDA) both directly and indirectly. The target population is new students class of 2023, with a sample of 290 people taken randomly. The primary data analysis technique applies a structural equation model (SEM) with the lisrel application program supported. The SEM uses the weight least squares estimation method. Digital marketing has a stronger influence on trust than on decisions to opt for. Trust influences decisions to opt. Trust mediates the influence of digital marketing on decisions to choose, but it’s partial. The Darma Agung University’s leaders should pay attention to social media.
Factors Influencing the Interest of the Muslim Generation in Cash Waqf in West Nusa Tenggara Province
Authors:   Faculty of Economics and Business, University of Mataram, Hadi Elvira Friska , Huzaini Moh. ,   Faculty of Economics and Business, University of Mataram, Hidayat Ali Akbar ,   Faculty of Economics and Business, University of Mataram
Published: October 2023

Cash waqf is a waqf fund in the form of a rupiah managed by the nazir to produce benefits in the form of marque alaih. This study aims to determine how big the factor of interest of the Muslim generation in cash waqf in West Nusa Tenggara Province (NTB). In this study, data was collected by distributing questionnaires by purposive sampling using the Cochran formula so that 100 respondents fulfilled the number of samples. Data analysis techniques using Partial Least Square-Structural Equation Modeling (PLS-SEM). The results showed that trust variables and subjective norms positively and significantly affected the interest in cash waqf in West Nusa Tenggara (NTB). Trust and subjective norm variables imply that the institution where waqf is collected can maintain trust in Wakif by making reports and documentation. At the same time, the promotion of socialisation and religiosity variables have a positive but insignificant effect. Moreover, the knowledge variable has a negative and little impact on the interest in cash waqf in West Nusa Tenggara Province.
Legal Review of Administrative Law Related to the Examination of Abuse of Authority by Government Officials in Corruption Cases in Indonesia
Authors:   Master of Law, Faculty of Law, Diponegoro University, Indonesia, Sabrina Nesa Anandia , S.H., M.Hum Dr. Joko Setiyono, ,   Master of Law, Faculty of Law, Diponegoro University, Indonesia
Published: October 2023

The conflict that arises is related to the abuse of authority by government officials in Indonesia. The problem that can be analyzed is to analyze it from a criminal law perspective related to examining the abuse of authority by government officials in corruption cases. This research uses a normative juridical research approach. The decisions and/or actions of government officials as objects of examination for abuse of authority in the Administrative Court (PTUN) are decisions and/or actions that involve administrative errors and result in state losses, as well as deviations in the criminal process. Therefore, in conclusion, the provisions in Article 21 of the Administrative Law can provide certainty regarding whether or not there is an abuse of authority by government officials in making decisions from an administrative perspective without necessarily involving corruption cases.
Psoriasis y uveítis
Authors: Barbini Carla , Suar Lucila , Eimer Lena , Ruiz Beguerie Julieta , Forges Fernanda , Schlaen Ariel
Published: October 2023

La psoriasis es una enfermedad inflamatoria caracterizada por el compromiso cutáneo, dado por la presencia de placas eritematoescamosas bien delimitadas que varían según la forma clínica. Es una patología crónica que cursa con brotes y remisiones. Se considera una enfermedad multisistémica, ya que puede manifestarse en la piel, las mucosas, las uñas y las articulaciones, así como en los ojos y los anexos oculares en un 10% de los pacientes. El ojo puede estar afectado con múltiples manifestaciones que van desde una afectación leve y superficial hasta casos de compromiso intraocular como la uveítis. El tratamiento varía desde corticosteroides tópicos hasta agentes biológicos. El objetivo de este trabajo de revisión fue recopilar la información más reciente sobre la psoriasis y su manifestación ocular: la uveítis.