bluuebunny/crossref_metadata_2025 huggingface dataset:
The (not-so) valid and reliable linguistic markers of depression and anxiety in symptomatic adults: A randomised cross over trial
Authors: O’Dea Bridianne , Batterham Philip J. , Braund Taylor A. , Chakouch Cassandra , Larsen Mark E. , Berk Michael , Torok Michelle , Christensen Helen , Glozier Nick
Published: September 2024

Psycho-linguistic theory postulates that linguistic features expressed in individuals’ communications may be valid indicators of their mental health. This trial aimed to examine the validity and reliability of linguistic markers of depressive and anxiety symptoms in adults. Using a randomised cross over trial design, 218 adults provided eight different types of text data of varying frequencies and emotional valance including SMS data, social media posts, personal expressive essays, and letters to a friend. Linguistic features were extracted from each task using LIWC22 software and correlated with participants’ self-report symptom scores. Machine learning models were used to determine which linguistic features had the strongest associations with symptoms. There were no linguistic features consistently associated with depressive or anxiety symptoms within tasks or across all tasks. Features found to be associated with depressive symptoms were different for each task and there was only some degree of reliability of these features within the repeated tasks. In all the machine learning models, predicted values were weakly associated with actual values for both depressive and anxiety symptoms. Some of the text tasks were found to have lower levels of engagement and negative impacts on participants’ mood. Overall, these findings indicate that there may be few valid and reliable group-level linguistic markers of depression and anxiety when examining several types of individuals’ text data.
Prevalence and trend of hypertension secondary data analysis from 2013 to 2020 of Mekelle zone, Tigray, Ethiopia, 2021
Authors: Berhane Tsegay , Zenebe Dawit , Yimer Mesfin
Published: September 2024

Introduction: Hypertension is a systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg that contributes to the burden of heart disease, stroke, kidney failure, and premature mortality and disability. There is limited evidence on the trend and magnitude of hypertension in Tigray, Ethiopia. Therefore, this study was designed to assess the magnitude and trend of hypertension among individuals visiting outpatient and inpatient units of health facilities in the Mekelle zone, Tigray, Ethiopia.
Methods: A descriptive cross-sectional study was conducted in the Mekelle zone, Tigray, Ethiopia from August 2nd-4th week, 2021. This study was done using secondary data from July 2013 to June 2020. The data was extracted from the health management information system and district health information software monthly report of Tigray Regional Health Bureau and analysis was done through Microsoft Excel 2020. Results were presented with texts, tables, graphs, and charts.
Result: Overall 53,386 outpatient cases, 4161 inpatient cases, and 135 deaths were reported during the seven-year reporting period due to hypertension. The overall prevalence of hypertension is 25/1000 with 28/1000 and 22/1000 in males and females respectively. Similarly, prevalence among ≥15 years was 44/1000 with 38/1000 in adult males and 50/1000 in adult females. The death rate was 6.8/1000 and 2.5/1000 among ≤15 years and adults. The trend of hypertension increased from 30/1000 (2013/14) to 43/1000 (2020) among adults ≥15 years.
Conclusion: The prevalence of hypertension in the Mekelle zone is higher among females and adults > 15 years old. Even though the magnitude of hypertension was higher in adults the death due to hypertension was higher among ≤15 years. This study also identified the increasing and decreasing trend of morbidity and mortality respectively. Public health officers and researchers should conduct further investigations to dig out the reason for the increased disease prevalence and its effects.
Programmable multifunctional integrated microwave photonic circuit on thin-film lithium niobate
Authors: Marpaung David , Wei Chuangchuang , Feng Hanke , Ye Kaixuan , Eijkel Maarten , Klaver Yvan , Keloth Akshay , CHEN Zhaoxi , Wang Cheng
Published: September 2024

Microwave photonics, with its advanced high-frequency signal processing capabilities, is expected to play a crucial role in next-generation wireless communications and radar systems. The realization of highly integrated, high-performance, and multifunctional microwave photonic links will pave the way for its widespread deployment in practical applications, which is a significant challenge. Here, leveraging thin-film lithium niobate intensity modulator and programmable cascaded microring resonators, we demonstrate for the first time a tunable microwave photonic notch filter that simultaneously achieves high level of integration along with high dynamic range, high link gain, low noise figure, and ultra-high rejection ratio. Additionally, this programmable on-chip system is multifunctional, allowing for the dual-band notch filter and the suppression of the high-power interference signal. This work demonstrates the potential applications of the thin-film lithium niobate platform in the field of high-performance integrated microwave photonic filtering and signal processing, facilitating the advancement of microwave photonic system towards practical applications.
Integrating Patient Metadata and Pathogen Genomic Data: Advancing Pandemic Preparedness with a Multi-Parametric Simulator
Authors: Gala Jean-Luc , Bonjean Maxime , Jérôme Ambroise , Francisco Orchard , Alexis Sentis , Julie Hurel , Jessica Hayes , Máire Connolly
Published: September 2024

Stakeholder training is essential for handling unexpected crises swiftly, safely, and effectively. Functional and tabletop exercises simulate potential public health crises using complex scenarios with realistic data. These scenarios are designed by integrating datasets that represent populations exposed to a pandemic pathogen, combining pathogen genomic data generated through high-throughput sequencing (HTS) together with patient epidemiological, clinical, and demographic information. However, data sharing between EU member states faces challenges due to disparities in data collection practices, standardisation, legal frameworks, privacy, security regulations, and resource allocation. In the H2020 PANDEM-2 project, we developed a multi-parametric training tool that links pathogen genomic data and metadata, enabling training managers to enhance datasets and customise scenarios for more accurate simulations. The tool is available as an R package: https://github.com/maous1/Pandem2simulator and as a Shiny application: https://uclouvain-ctma.Shinyapps.io/Multi-parametricSimulator/, facilitating rapid scenario simulations. A structured training procedure, complete with video tutorials and exercises, was shown to be effective and user-friendly during a training session with twenty PANDEM-2 participants. In conclusion, this tool enhances training for pandemics and public health crises preparedness by integrating complex pathogen genomic data and patient contextual metadata into training simulations. The increased realism of these scenarios significantly improves emergency responder readiness, regardless of the biological incident's nature, whether natural, accidental, or intentional.
Estimation of Soil Loss Using the RUSLE Model Integrated with GIS Tools: A Case Study of the Ribb Dam Catchment, Upper Blue Nile Basin, Ethiopia
Authors: Tefera Tamene , Teshome Asirat , Tadesse Workineh , Tadesse Adugnaw
Published: September 2024

Soil erosion is a major environmental challenge, particularly in watersheds such as the Ribb Dam catchment, which contributes to sediment deposition in reservoirs and reduces the lifespan of dams. This study estimates the total soil loss from the Ribb Dam catchment using the Revised Universal Soil Loss Equation (RUSLE) model, integrated with Geographic Information Systems (GIS). The RUSLE model evaluates soil erosion based on five factors: rainfall erosivity (R), soil erodibility (K), slope length and steepness (LS), land cover (C), and conservation practices (P). Input data for these factors were collected from Landsat satellite images, soil maps, rainfall data, and a 12.5m resolution Digital Elevation Model (DEM). The model was used to identify erosion hotspots and assess the severity of soil loss across the catchment. The estimated annual soil loss ranged from 0 to 50 tons per hectare per year, with an average of 25 t/ha/yr. Approximately, 96% of the watershed experienced slight to very slight soil loss, while 4% of the area faced moderate to severe erosion, predominantly in the northern and central regions. The findings indicate that these areas require urgent conservation efforts to mitigate soil loss and ensure the long-term sustainability of the Ribb Dam. The integration of the RUSLE model with GIS provides a powerful tool for soil erosion prediction and conservation planning in erosion-prone watersheds.
A Multifaceted Hybrid ES-Robotic Device for Gait Training in Individuals with Neurological Disorders
Authors: Ambrosini Emilia , Dell'Eva Francesca , Guanziroli Eleonora , Camerini Viola , Gandolla Marta , Brignole Laura , Maludrottu Stefano , Gruppioni Emanuele , Ferrigno Giancarlo , Molteni Franco , Pedrocchi Alessandra
Published: September 2024

The integration of robotics and Electrical Stimulation (ES) in neurorehabilitation combines the precise execution of complex tasks enabled by robotics with motor learning, muscle conditioning, and cardiovascular fitness induced by ES. We propose a hybrid lower-limb exoskeleton for gait training to maximize these benefits. Two neuromuscular electrical stimulators and a 4-degrees-of-freedom motorized exoskeleton were combined with different modalities: ES-motor cooperative integration for the swinging knee, synchronized but independently operating ES and motors for the hip both in swing and in stance phases, and for the knee during stance, and ES-only for the non-actuated ankle. Two conditions - exoskeleton only and hybrid - were compared on twelve non-disabled subjects and eleven participants with neurological disorders. Electrical stimulation reduced the output motor torque at the knee by approximately 50%, while maintaining comparable movement performance (tracking errors <8° in both conditions and groups). Overall, the hybrid system was perceived as more usable by participants with neurological disorders compared to the exoskeleton alone, with an improvement of around 16%. These results are promising for developing lighter exoskeletons with potentially enhanced therapeutic benefits for motor learning.
Ezochiite and shiranuiite = cuprorhodsite and are not new mineral species
Authors: Cabri Louis J. , McDonald Andrew M.
Published: September 2024

Ezochiite was described as a newly–discovered platinum–group mineral in the thiospinel group having an ideal formula of Cu+(Rh3+Pt4+)S4 (Nishio-Hamane and Saito, 2024), but the data presented show it is a platinian cuprorhodsite, Cu(Rh,Pt)2S4 (Cabri et al. 2023; Rudashevsky et al. 1985). Similarly, Nishio-Hamane et al. (2024) describe shiranuiite as a new mineral having an ideal formula of Cu+(Rh3+Rh4+)S4 on the basis of assumed valences. Thus, instead of weighing the significance of chemical substitution in a PGE-dominant thiospinel, the readership is instead burdened with accepting that there are three potential minerals with virtually identical crystal structures and similar, but supposedly distinct, chemical compositions. In the absence of any new, compelling data, particularly in regard to the valences of the ions present in both ezochiite and shiranuiite, it is argued that both are not new mineral species but instead represent varieties of cuprorhodsite.
Att fästa sig vid staten. Äktenskap, arbete och ansvar i svensk samhällsdebatt 1750–1830
Authors: Jansson Karin Hassan
Published: September 2024

Uttrycket ”att fästa sig vid staten” är en omskrivning för att ingå äktenskap: när en man gifte sig ansågs han också fästa sig vid staten och bli en kugge i ett större sammanhang. Äktenskapet sågs i slutet av 1700-talet som ett fundament för samhällsordningen. Men vad låg bakom den uppfattningen och hur diskuterades frågor om äktenskap? I riksdag, tidningar, pamfletter och rådgivningslitteratur lade skribenter och andra debattörer ut texten om varför äktenskapet var så viktigt och hur äkta makar skulle leva sina liv för att gynna det allmänna bästa. Sprätthöken, tyrannen och toffeln var, tillsammans med regeringslystna och flärdfulla fruntimmer, några av de figurer som förekom. Karaktärerna fungerade som avskräckande exempel och bidrog till att forma de normer om kön, arbete, ansvar som präglade Sverige kring sekelskiftet 1800.
Influência da incapacidade funcional na qualidade de vida em pacientes com parkinsonismo atípico
Authors: Martins Cíntia Costa Medeiros , Artigas Nathalie Ribeiro , Pasqualotto Amanda , Schuh Artur Francisco Schumacher , Schwartz Ida Vanessa Doederlein , Strelow Matheus Zschornack , Rieder Carlos Roberto de Mello
Published: September 2024

Objetivo: avaliar o nível de capacidade funcional e associar com a qualidade de vida (QV) de pacientes com parkinsonismo atípico (PA). Métodos: Trata-se de um estudo transversal com uma avaliação clínica por médico e fisioterapeuta para confirmação do diagnóstico de PA e conclusão da análise clínica; Timed Up and Go (TUG), força de preensão manual, escala para avaliar QV na doença de Parkinson (PDQ-39), Escala de Hoehn & Yahr (H&Y), Frontal assessment battery (FAB) e Montreal Cognitive Assessment (MoCA). Resultados: Foram recrutados 21 pacientes idosos com PA, predomínio do sexo masculino (76%), incapacidade funcional através do TUG>20 segundos em 80% dos pacientes, e dinapenia presente em 57%. Estratificando os pacientes com e sem dinapenia, encontramos que aqueles que possuem dinapenia tem pior QV pelo questionário PDQ-39 (p=0.04). Ainda encontramos correlação significativa e negativa entre os valores de dinamometria no membro dominante (Kgf) e QV dos pacientes com PA (R= -0.449 e P= 0.049); correlação significativa e positiva, em que a gravidade da PA avaliada pela escala de Hoehn & Yahr influencia diretamente na resposta da capacidade funcional pelo teste de TUG (R= 0.580 e P= 0.009) e correlação significativa entre o MOCA e o FAB (R= 0.867 e P= 0.001). Corroborando com esses resultados, encontramos resultado significativo na regressão linear, onde determinamos a influência direta da funcionalidade na QV desses pacientes. Conclusão: A gravidade da PA impacta negativamente na funcionalidade e consequentemente gera prejuízos na QV em pacientes diagnosticados com PA.
Research on quantitative design methods for the durability of reinforced concrete structures in a hot ocean environment
Authors: Guo Guohe , Sun Lizhou , Zhao Shangchuan , Liu Longlong
Published: September 2024

This paper establishes a quantitative design method for the durability of concrete structures in cross-sea bridges through investigation, rapid chloride migration coefficient method (RCM) and theoretical calculation, considering the impact of temperature on chloride ion diffusion rates in a hot marine salt erosion environment. Combined with the RCM test and bridge service data, a quantitative design method for bridge concrete durability is proposed. Test results show that the growth rate of the chloride ion diffusion coefficient of concrete is approximately 1.028 for every 1 °C increase. For every 5 °C increase, the growth rate of the chloride diffusion coefficient of concrete is about 1.15, and the cover depth of the concrete structure should be multiplied by a coefficient of 1.07. Therefore, the concrete cover depth should be appropriately increased, considering the influence of ambient temperature. Furthermore, fly ash, slag, and stone powder can increase the concrete’s resistance to chloride corrosion. When the influence of temperature on the chloride ion diffusion coefficient is considered, the durability design of the concrete structure of the sea-crossing bridge is conducted, which is beneficial for ensuring their service life.
HPV-16 Biosensing Systems for Diagnosing Early Stages and Monitoring Oropharyngeal Cancer
Authors: Lakshmipriya Thangavel
Published: September 2024

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An Overview of Microfluidic Phenotype Separation of Bacteria
Authors: Juliet Vimala , Ganesan Sanchanna , C Likith Kumar , Muthuramamoorthy Muthumareeswaran , Alzahrani Khalid E , Alodhayb Abdullah N
Published: September 2024

With the development of microfluidics technology, it is now possible in medical biotechnology to
examine clinical and rapid diagnostic operations involving pathogens, like bacteria and viruses. The method
of separating bacteria from complicated homogeneous and heterogeneous samples is one of the most important
steps in the diagnostic process. The microfluidic technology for bacterial separation offers a better and
more promising platform by combining several physical properties and characteristics of bacteria. In contrast,
the conventional method is time-consuming, limited to a few cell properties, and necessitates the completion
of several challenging steps and processes involving skilled manpower. The microfluidics platform also has a
number of advantages, including small-scale size, low cost, high efficiency, and simultaneous detection and
execution of further steps. This enables cell separation, analysis, and experimental processing on a single chip.
In this paper, we have analysed the mechanism of the bacterial separation process depending on phenocharacteristics
along with their benefits, constraints, and applications. In addition, the performance metrics
needed for the separation of the devices along with the challenges and future possibilities of developed devices,
which are described in the literature, are discussed in detail. Thus, this review offers a holistic analysis of
the separation of bacteria using microfluidic technology.
The Direct use of Metallic Ore Minerals as Catalysts in Organic Syntheses
Authors: Milen Mátyás , John Tamás Miklós , Pollák Patrik , Keglevich György
Published: September 2024

:

Minerals occurring on earth have been used as raw materials by mankind for
thousands of years. Currently, more than 6000 mineral species are known, and a few of
them are common or abundant. It has long been known that minerals can catalyse chemical
processes. The catalytic activity of metallic ore minerals has been investigated primarily in
coal liquefaction and prebiotic chemistry and, to a lesser extent, in organic syntheses. This
review article discusses organic chemical reactions, in which metallic ore minerals have
been used as catalysts.
Target and Gene-Based Therapeutic Strategies against Pancreatic Cancer: Current and Future Prospects
Authors: Dwivedi Medha , Sanyal Sayak , Singh Sakshi , Dwivedi Manish , Sanyal Somali
Published: September 2024

Despite tremendous advancements in knowledge, diagnosis, and availability of both traditional
and innovative treatments, pancreatic cancer remains a dangerous disease with a high
death rate and dismal prognosis. The traditional strategy in adjuvant and palliative settings is still
cytotoxic chemotherapy predicated on the purine derivative gemcitabine; nevertheless, there is an
increasing need for new medicines that target the primary molecular pathways and pathophysiological
abnormalities implicated. There is now just a tiny amount of evidence of therapeutic benefit
when the targeted drug erlotinib is added to the conventional gemcitabine treatment. In preclinical
and clinical trials, novel medications targeting mTOR, NF-κB, and proteasome, including the enzyme
histone deacetylase, are currently being studied alongside the well-established monoclonal
antibody treatments and small-molecule protein tyrosine kinase inhibitors. These novel medications
may change the negative natural progression of this illness in conjunction with gene therapy
and immunotherapy, both of which are undergoing clinical study. In this regard, leveraging miRNA
manipulation to combat cancer is appealing due to its promise to deliver personalized treatment
tailored to an individual's distinct gene or miRNA expression profile. Preclinical studies involving
animals have showcased the effectiveness of miRNA-based therapies, with several of these
treatments now progressing into human clinical trials for various malignancies and other medical
conditions. This review describes the important developments of targeted therapeutics that are
associated with pancreatic cancer and the discoveries which can help in dealing with this fatal malignancy
in a more significant manner.
An Overview of Possible Beneficial Effects of Black Seeds (Nigella Sativa) on the Management of “Disease X”
Authors: Maideen Naina Mohamed Pakkir , Balasubramanian Rajkapoor
Published: September 2024

A mystery pathogen that has not yet infected the entire world’s population is predicted to be the cause of Disease X, which will be contagious. According to WHO scientists, 50 million people are expected to die from Disease X, which would be 20 times deadlier than coronavirus disease 2019 (COVID-19). Many international initiatives are currently in motion to get ready for future pandemics. These include updating the International Health Regulation and the European Legislation, establishing the Health Emergency Preparedness and Response Authority (HERA), establishing international hubs, taking on the international challenge of developing a vaccine for Disease X within 100 days of recognition of emerging Pathogen X, and updating the prepared-ness plan of National Institute of Allergy and Infectious Diseases. Our current review’s main objective is to determine whether black seeds (Nigella sativa) can manage Disease X. It has been established by several studies that black seeds (N. sativa) have antiviral, antibacterial, antimicro-bial, immunomodulatory, anti-inflammatory, and antioxidant properties, which would be useful in the management of Disease X. Black seeds (N. sativa) may be utilized in conjunction with supportive care and symptomatic therapy to manage Disease X in early phases. Future random-ized controlled clinical trials would further evaluate the safety and effectiveness of black seeds (N. sativa) in patients with Disease X.
Revolutionising Neurological Therapeutics: Investigating Drug Repurposing Strategies
Authors: Attri Meenakshi , Raghav Asha , Sinha Jyoti
Published: September 2024

Repurposing drugs (DR) has become a viable approach to hasten the search for cures for
neurodegenerative diseases (NDs). This review examines different off-target and on-target drug
discovery techniques and how they might be used to find possible treatments for non-diagnostic
depressions. Off-target strategies look at the known or unknown side effects of currently approved
drugs for repositioning, whereas on-target strategies connect disease pathways to targets that can be
treated with drugs. The review highlights the potential of experimental and computational methodologies,
such as machine learning, proteomic techniques, network and genomics-based approaches,
and in silico screening, in uncovering new drug-disease correlations. It also looks at difficulties and
failed attempts at drug repurposing for NDs, highlighting the necessity of exact and standardised
procedures to increase success rates. This review's objectives are to address the purpose of drug
repurposing in human disorders, particularly neurological diseases, and to provide an overview of
repurposing candidates that are presently undergoing clinical trials for neurological conditions,
along with any possible causes and early findings. We then include a list of drug repurposing strategies,
restrictions, and difficulties for upcoming research.
In-Vitro Evaluation of The Stain Removal Efficacy Between Two Whitening Dentifrices During Orthodontic Treatment
Authors: Yeoh Zhen Herr Eugene , Khan Khairil Aznan Mohamed , Marizan Nor Murshida , Baharin Badiah , Rani Haslina
Published: September 2024

Background

This in-vitro study aimed to assess and compare the efficacy of a newly developed whitening dentifrice, Dentaklin White (TG), to Colgate Total® Whitening (CG), utilising a toothbrushing simulator machine.

Methods

Twenty enamel specimens were prepared and randomly divided into CG and TG. Orthodontic brackets were attached to the enamel specimens and were then stained with a mixture of coffee, tea, and chlorhexidine. A short 0.019x0.025” stainless steel (SS) archwire was ligated onto the brackets subsequently. All the specimens were subjected to a toothbrushing simulator for specific duration. The CIE L*a*b* colour change (ΔE) was evaluated using digital image analysis at T1 (2 weeks), T2 (4 weeks), and T3 (12 weeks) compared to T0 (baseline). Archwire roughness was analysed using a profilometer at T4 (2 years) compared to T0.

Results

The results indicated that there was a significant change in tooth colour associated with brushing duration for both CG and TG (p<0.05) with no significant difference between the two dentifrices (p>0.05). Both dentifrices notably removed more stains at Site A (p<0.05) and increased wire surface roughness (p<0.05) without a statistically difference between them (p>0.05).

Conclusion

Dentaklin White (TG) demonstrated comparable efficacy to Colgate Total® Whitening (CG).
Exploring Caregiver Burden in Alzheimer's Disease: The Predictive Role Of Psychological Distress
Authors: Ameri Fatemeh , Rahmani Hedie , Mirhosseini Seyedmohammad , Basirinezhad Mohammad Hasan , Saeedi Maryam , Ebrahimi Hossein
Published: September 2024

Background

Alzheimer's Disease [AD], the most prevalent form of dementia, is on the rise in terms of its prevalence. Individuals affected by this condition typically require extensive care across all aspects of daily living. The mental well-being of caregivers for those with dementia stands as a significant public concern. Therefore, the current study aimed to investigate the association between the burden of caregiving and the psychological distress experienced by family caregivers of individuals with AD.

Methods

This cross-sectional study employed a census method and involved the participation of 150 caregivers of Alzheimer's patients in Shahroud, Iran. To assess the eligibility of family caregivers, the inclusion criteria comprised minimal literacy in reading and writing and at least six months of care for an individual with AD.. Exclusion criteria included being a formal caregiver or employed in healthcare, having mental disorders, or using neuroleptic drugs among family caregivers. Data collection tools consisted of the Zarit Care Burden Inventory [ZBI] and Lovibond's Depression, Anxiety, and Stress Scale [DASS-21]. Information was gathered online and through self-reporting, followed by analysis using descriptive statistics [frequency, percentage, mean, and standard deviation], as well as inferential statistical tests [multivariate linear regression].

Results

In this study, the mean scores for caregiver burden, anxiety, stress, and depression were 28.09 ±13.01, 4.50 ±4.53, 8.12 ±4.98, and 4.69 ± 4.86, respectively. The study's findings revealed that with each additional hour spent on daily patient care, the burden score for caregivers increased by 0.327 units [p=0.025, β=0.327]. Furthermore, for every one-unit rise in stress [p<0.001, β=1.087] and depression scores [p=0.015, β=0.671], the burden score also increased by 1.087 and 0.671 units, respectively.

Conclusion

Caregivers of individuals with AD experienced notable levels of caregiving burden, particularly correlated with the duration of daily patient care and the manifestation of stress and depression symptoms. Hence, the study suggests the implementation of tailored interventions, such as psychoeducational programs, to provide vital support for these individuals.
4-hydroxyderricin from Angelica keiskei: Analysis, Preparation, and Multiple Skin Care Effects
Authors: Gong Xu , Tian Yun-Cai , Tian Yong , Zhang Wen-Huan , Wen Yan , Luo Yong-Xin , Wu Ri-Hui , Xu Xue-Tao , Gan Li-She
Published: September 2024

Introduction:

The content of the bioactive component 4-hydroxyderricin (4-HD) in the
roots, stems, and leaves of Angelica keiskei (Umbelliferae), a well-known medicinal and edible plant,
was analyzed by HPLC. The dry root contained the highest level (2. 69 ± 0.09 mg/g) of 4-HD, which
was then prepared and spectroscopically identified by column chromatography. Method: The multiple
skin care activities of 4-HD, including skin whitening, anti-allergy, and anti-inflammation, were
evaluated on enzymatic and cellular models. 4-HD showed a significant inhibitory effect on mushroom
tyrosinase, and it could also strongly suppress the activity of tyrosinase in B16F10 cells. A
molecular docking study revealed that 4-HD could closely bind to tyrosinase through hydrogen
bonding and hydrophobic interactions. Results: In the anti-allergic assay, 4-HD could effectively
reduce the degranulation rate in the neutral red staining test and largely down-regulate the release
level of β-HEX in RBL-2H3 cells at the concentration of 5 μM. 4-HD decreased the production of
NO in RAW264.7 cells induced by Lipopolysaccharide (LPS), showing its anti-inflammatory effect.
Conclusion: The skin whitening, anti-allergic, and anti-inflammatory effects of 4-HD have clearly
demonstrated its potential usage in the pharmaceutical and cosmetic industries.
COVID-19 Vaccination-Induced Pityriasis Rubra Pilaris
Authors: Zavaleta-Monestel Esteban , Arguedas-Chacón Sebastián , García-Montero Jonathan , Quesada-Villaseñor Ricardo , Díaz-Madriz José Pablo , Rojas-Chinchilla Carolina , Hernández-López Josephine , Zovi Andrea , Langella Roberto
Published: September 2024

Amidst the COVID-19 pandemic, the rapid development of vaccines transformed immunization
strategies. With 70.6% of the global population vaccinated with at least one dose and 13.53
billion doses administered worldwide, certain dermatological side effects like Pityriasis Rubra Pilaris
(PRP) have been linked to the COVID-19 vaccination. This review aims to critically analyze the
existing evidence on the correlation between COVID-19 vaccination and PRP, emphasizing its incidence
and management strategies. A review of 62 articles was conducted, of which only 19 met the
inclusion criteria. Out of these, 16 had complete information necessary for the review. The review
identified 16 cases of PRP, predominantly in males (62.5%) with an average age of 59. A significant
percentage (44%) of cases occurred approximately 12 days after the third dose (booster). Symptoms
commonly included painful rashes, itching, and erythematous, reddish, scaly plaques. Treatments
varied, with oral retinoids and monoclonal antibody-based biological therapies being the most common.
The importance of continuous monitoring of dermatological side effects, such as PRP, is underscored,
especially as the world population will require ongoing booster shots. Standardizing PRP
treatment is a critical step toward ensuring optimal patient care.
Dynamics of Interaction of One Prey and Two Competing Predators with Population Heterogeneity
Authors: Dr Raveendra Babu  , Imtiyaz Ahmad Wani
Published: September 2024

A mathematical model of two predators competing for a single prey system incorporating population heterogeneity has been proposed and analyzed by extending the system of coupled logistic equations for three species system. The local stability analysis of all the equilibria has been carried out and also globally stable in Varies 2-D planes. Through the analytical results, it is observed that the interior equilibrium of one prey and two competing predators in prey dependent case is always unstable. At the end, discussed the dynamical behavior of a three species interaction with the help of some numerical examples by using MATLAB to support the analytical presentations.
Chronic Obstructive Pulmonary Disease Exacerbation Complicated with Pneumonia and Lung Cancer: An Evidence-based Case Report of Erdosteine Role in the Management of Complex COPD
Authors: Ilham Ahmad Fadhil , Rakasiwi Muhammad Ilham Dhiya , Felim Ris Raihan , Arfan Ahmad , Burhan Erlina
Published: September 2024

Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are strongly associated with poor health status and morbidity. Erdosteine is a mucolytic agent that also has anti-inflammatory, antioxidant and antibacterial effects. This case report aims to evaluate the role of erdosteine in the prevention and treatment of acute exacerbations of complex COPD case.
Case: A 73-year-old male arrived at the emergency department with an increased difficulty in breathing that had deteriorated over the previous 5 days, and had a history of heavy smoking for more than 40 years. Following a thorough examination, he was diagnosed with acute exacerbation of COPD (Anthonisen criteria type 2) in clinical group E, pneumonia, along with stage IIIA right lung tumor (T4N1Mx), and received erdosteine inhalation as part of his treatment.
Discussion: A comprehensive search of journal databases (PubMed, EMBASE, CENTRAL, EBSCO Medline, Scopus, and ProQuest) was conducted using specific keywords, critical appraisal based on the Oxford Center for Evidence-Based Medicine. Article selection resulted in 1 systematic review article for the prevention of acute exacerbations and 1 systematic review article for the management of acute exacerbations of COPD. In patients with stable COPD, administration of erdosteine in the standard COPD regimen significantly reduced the risk of exacerbations (RR=0.65; p=0.01), while in patients with acute exacerbations of COPD, erdosteine increased treatment success (OR=3.2; p<0.0001).
Conclusion: Erdosteine may serve as a therapeutic choice for COPD patients in preventing or managing acute exacerbations.
Religious and Traditional Fasting May Be an Alternative Method to Tackle Global Health Threats and the Epidemic of Obesity
Authors: Armutcu Ferah
Published: September 2024

Intermittent fasting practices, recommended as a potential nutritional approach against obesity and metabolic diseases, have become increasingly widespread in recent years. Although convincing data on the anti-obesity and cardio-metabolic benefits of intermittent fasting are obtained mostly from experimental studies, religious and traditional fasting practices have been among the treatment methods applied for human health for centuries. Both intermittent fasting and religious fasting may be a promising strategy for weight loss and improving metabolic health as well as combating the obesity pandemic. In this context, in addition to proven experimental and clinical studies, this review suggested that fasting can be one of the important cornerstones of an integrative treatment approach, as it is a religious, traditional, and widely known method worldwide. It also claims that it can be a useful and sustainable method in the fight against both obesity and factors that threaten planetary health.
Preservar nuestra herencia: experiencias de custodios de semillas en conservación de agrobiodiversidad en el Cauca
Authors: Manzano Mompotes Ricardo Alfredo , Rojas Vargas Carol Yohanna , Patiño Moscoso Manuel Alfonso , Jiménez Guzmán Ana María , Rodríguez Robayo Karla Juliana , Osorio Guerrero Karen Viviana , Pulido Castro Sandra Xiomara , Valencia Sánchez Juan Sebastián , Rodríguez Molina John Fredy , Lasso Paredes Zahara Lucía , Ramírez Durán Julio
Published: September 2024

El objetivo de esta cartilla es dar a conocer la labor de los custodios de semillas, algunas de sus experiencias y la importancia de su papel en la conservación de la agrobiodiversidad en el departamento del Cauca. Esta publicación también presenta información relevante sobre la diversidad de semillas nativas y criollas presentes en los territorios de las diez zonas que hacen parte del CRIC. En dichas zonas ha sido crucial el papel de los custodios y custodias de semillas, pues, gracias al intercambio de semillas como mecanismo tradicional, ellas y ellos han logrado dinamizar y mantener la diversidad local, así como promover la recuperación biológica y cultural de las semillas; todo lo cual redunda en el fortalecimiento de la soberanía alimentaria de los territorios. Este trabajo, en consecuencia, espera contribuir al fortalecimiento de los procesos locales de producción de semillas de calidad y al reconocimiento del papel que realizan custodias y custodios en los territorios, ya que son los principales proveedores locales de semillas nativas y criollas, y contribuyen a preservar la identidad cultural y la soberanía alimentaria. Vale aclarar que este trabajo es el resultado de una síntesis de los esfuerzos realizados por el CRIC y AGROSAVIA.
Comportamiento agronómico, adaptación y estabilidad de híbridos de maíz bajo condiciones tropicales en Ecuador
Authors: Limongi Andrade Ricardo , Sanchez-Mora Fernando David , Mora Yela Raúl V. , Pico Mendoza José , Navarrete Cedeño Bernardo , Alarcón Cobeña Daniel , Peña Monserrate Geover , Ochoa Ramos Jim , Perez-Almeida Iris , Garcés-Fiallos Felipe R.
Published: September 2024

El maíz es uno de los cereales más sembrados y consumidos a nivel mundial. Las condiciones ambientales juegan un papel esencial en la interacción genotipo × ambiente y su potencial productivo. Durante la época lluviosa de 2016, 2017 y 2018, se evaluó el potencial agronómico, fitosanitario, productivo y adaptativo en 18 híbridos de maíz amarillo, en cinco localidades de ambiente tropical: Lodana, Jipijapa y Tosagua (Manabí); Mocache (Los Ríos); y Zapotillo (Loja). Para determinar el efecto de híbridos entre y dentro ambientes se utilizó el análisis de varianza y la prueba de Tukey (p <0,05). Los parámetros de adaptabilidad y estabilidad se estimaron mediante la regresión bisegmentada. Las características fitosanitarias se correlacionaron significativamente con las productivas. El rendimiento de grano se correlacionó con altura de inserción de la mazorca, plantas cosechadas por parcela, número de mazorcas cosechadas, aspecto de mazorca y roya. La interacción genotipo × ambiente mostró una respuesta diferenciada de los híbridos en cada ambiente. El genotipo G1 (G.I.2.10-1-1-1xL.I.4) se adaptó mejor a la mayoría de las localidades, mostrando rendimientos mayores que los demás materiales. El genotipo G10 (G.I.3.39-3-1-1xPORT.PHAEO.1AS2.4-1-1-1) respondió mejor a los ambientes favorables. Los híbridos prometedores G1, G2, G3, G5, G7, G9 y G11 podrían ser de interés para entornos favorables, mientras G8 podría explorarse para entornos desfavorables. Jipijapa y Tosagua (Manabí) y Zapotillo (Loja) mostraron un mejor desempeño en la producción de maíz, en al menos dos años de evaluación, siendo Tosagua la más estable para producir híbridos de maíz en el Ecuador.
Representation of Mental Health in 20th-Century British and Indian English Novels: A Comparative Analysis
Authors: Jha Aarya , Suri Dr. Girija
Published: September 2024

This paper examines the nuanced representations of mental health in 20th-century British and Indian English literature, highlighting the intricacies and cultural contexts that shape these portrayals. For this purpose, this paper picks up the following texts for a comparative appraisal— Mrs. Dalloway (1925) by Virginia Woolf, Nineteen Eighty-four (1949) by George Orwell, The English Teacher (1945) by R.K. Narayan, and Cry, the Peacock (1963) by Anita Desai. These novels offer profound insights into the characters' mental state, reflecting the societal attitudes toward mental health in that period. By comparing these texts, the paper sheds light on how mental health is a universal and culturally specific issue, shaped by historical and social factors.
Análisis metodológico del artículo: “Síndrome cardiorrenal en pacientes con falla cardiaca en un hospital universitario”
Authors: Burga Cisterna Cesar , Ruiz Tejada Lizzi , Acevedo Vences Fabricio Arturo
Published: September 2024

Hemos leído con gran interés el artículo: “Síndrome cardiorrenal en pacientes con falla cardiaca en un hospital universitario”, de Rozo et al., del cual resaltamos el aporte del artículo al conocimiento del síndrome cardiorrenal; no obstante, se observan algunos detalles que merecen ser analizados.
Con respecto a la redacción, se sugiere que los objetivos mencionados en el resumen tengan una concordancia con los objetivos mencionados en las otras secciones del artículo, así, en el resumen se menciona que se evaluará la frecuencia del síndrome cardiorrenal sin especificación del tipo de síndrome cardiorrenal, mientras que en la introducción sí se indica que se evaluará el síndrome cardiorrenal del tipo II; sin embargo, en las conclusiones nuevamente se menciona solo como “síndrome cardiorrenal” sin especificación del tipo. Además, en la sección de resultados existe un aumento de 20 pacientes de la muestra en la tabla 3, donde se menciona a 367 pacientes, contradiciendo lo mencionado en la sección de materiales y métodos, donde se describe que el tamaño de la muestra es de 347 pacientes en total, existiendo una diferencia de 20 participantes. Esta diferencia genera dudas sobre cuál es el tamaño de muestra real utilizado, existiendo la posibilidad de influenciar en el resultado y las conclusiones.
Laicismo estatal, Estado laico, Estado confesional
Authors: Gómez Pineda Floro Hermes
Published: September 2024

Este artículo de revisión narrativa, que recoge una fracción de trece años de trabajo académico, resulta del estudio de fuentes impresas publicadas por autores que representan las tres grandes corrientes políticas clásicas de la Modernidad: socialismo, liberalismo y conservadurismo, a partir de cuyos textos se realiza un ejercicio sintético de analogía-contraste (semejanzas-diferencias) entre las cualidades o singularidades propias, peculiares o consustanciales, la composición o caracterización, las líneas de continuidad y las particularidades típicas representativas del Laicismo estatal, el Estado laico y el Estado confesional como unas de las tantas tipicidades propias distintivas de las tres grandes corrientes políticas referidas.
Cada una de estas peculiaridades, particularidades o manifestaciones inherentes que distinguen una de otra a las tres grandes corrientes políticas de la Modernidad será tratada como una unidad con el fin de evitar confusiones y burdas simplificaciones que destruyan sus fundamentos y socaven los principios filosóficos de cada una de ellas. Igualmente, el texto Laicismo estatal Estado laico Estado confesional se organiza en tres apartados, uno por cada particularidad, expresión, característica o singularidad, y se divide cada apartado en iguales secciones con títulos análogos para que el lector pueda establecer las semejanzas y diferencias.
Alfabetización política: un concepto clave a considerar para una educación al servicio de la justicia social en el contexto chileno
Authors: De la Iglesia Priscilla Echeverría
Published: September 2024

Al observar la sociedad chilena desde una perspectiva crítica de justicia social, es posible identificar que la mayoría de las injusticias radican en una opresión institucionalizada (Young, 2011) y una falta de reconocimiento (Honneth, 1995) ejercida por las élites económicas hacia el resto de la población, facilitada por una cultura neoliberal que ha debilitado el interés de las personas por los asuntos públicos y fomentado su pasividad como sujetos políticos. Si bien el estallido social de octubre del 2019 ha favorecido un ambiente de mayor discusión política cotidiana en la sociedad chilena, la falta de formación política no ha sido subsanada.
Este artículo propone explorar la relación entre el concepto de analfabetismo político (Giroux, 2016) y justicia social, como camino para comprender la generalizada indiferencia política que ha caracterizado a la sociedad chilena durante décadas frente a las injusticias que ha vivido, y valorar el papel que la educación podría jugar en desarrollar alfabetización política como una dimensión de agencia, contribuyendo con ello a desarrollar una sociedad más autónoma y protagonista de su propio destino.
Autonomía Universitaria: Principios filosóficos, políticos y jurídicos
Authors: Gaviria Liévano Jorge
Published: September 2024

La autonomía universitaria está en clara relación con el grado de libertad que tienen los centros de enseñanza frente a los poderes políticos, religiosos o económicos. Han sido generalmente abanderados de la autonomía universitaria quienes profesan ideas democráticas.
Study of vibration protection system of the operator’s seat under polyharmonic external influences
Authors:   Siberian State Automobile and Highway University, Korytov M.S. , Sherbakov V.S. ,   Siberian State Automobile and Highway University, Kashapova I.E. ,   Siberian State Automobile and Highway University
Published: September 2024

The problem of protection of operators of ground transportation and technological machines from vibrations is actual. A mathematical model with one translational degree of freedom is used for the vibration protection system of the operator’s seat. RMS values of vertical acceleration of the vibration-protected mass, i.e. the seat with the operator, should not exceed the limit values established by sanitary norms. Vibrations in the frequency range up to 40 Hz are the most dangerous. The values of parameters of external influences in the form of harmonic vibrations of the floor of the opera-tor’s cabin are established, at which the established limit values of RMS acceleration of the seat with the operator are observed. For this purpose the calculation scheme is developed and the parameters of harmonic influence on the base of the vibration protection system are allocated. Analytical expressions linking the acceleration and amplitude of absolute displacements of the vibration-protected mass with the acceleration and amplitude of harmonic forcing vibrations of the base, as well as the amplitude of the suspension stroke are obtained. Numerical summation of harmonic vibrations of the seat base causing limiting RMS accelerations at various frequencies up to 40 Hz, specified by sanitary norms, al-lowed to consider complex vibrations of the seat at polyharmonic vibrations of the base. At polyharmonic influences with the use of deduced analytical expressions, for the mass of the seat with the operator one hundred kilograms, the dependences of accelerations of the vibration-protected mass and the seat base on the structural parameters of the system, such as the stiffness coefficient and the viscous friction coefficient of the vibration-protecting mechanism were obtained. It was found that the rms value of absolute accelerations of the vibration-protected mass at complex displacements of the base remains approximately constant at different values of the stiffness coefficient and resistance coefficient of the system. At the same time, polyharmonic vibrations of the seat base, are characterized by a large scatter of the value of the RMS acceleration. The highest value of the RMS acceleration of the seat base is achieved at values of the stiffness coefficient and resistance coefficient of the system close to zero.