bluuebunny/crossref_metadata_2025 huggingface dataset:
06. Elements of Resistance in Meer Beebagr Rind’s Poetry
Authors: Dr. Rahim Bakhsh Mehr Abdul Raziq (Raziq Raj),
Published: December 2021

Mir Beebagar Rind is known as one of the pioneers of resistance and protest in classical Balochi poetry. He actively participated in many battles during the Thirty Years' War, fought between Rind and Lashars in the fifteenth century. His poetry is a comprehensive account of the wars and battles he fought gallantly. Apart from themes and motifs of resistance and protest, Beebagr's poetry is also tinged with hues and shades of love and romance. This article primarily discusses various elements of resistance and protest of Mir Beebagr's poetry.
07. The Revival of Trends and Social Values of the Contemporary Ghazal in the Perspective of Classical Ghazal
Authors: Dr. Muhammad Afzal Butt Dr. Shabnam Niaz,
Published: December 2021

This article talks about the literature of every era under the ever changing influence of civilization and society. The revival of trends and social values exist accidents or mishaps of the period may decrease their importance but they cannot uproot them. In classical and contemporary Ghazal the revival and continuity of topics, trends and social values can be seen clearly in contemporary Ghazal like classical Ghazal’s era also deeply influence by the changing trends of the era. Now under the influence of new trends and ever changing thoughts the preference is given to observation too. We see the new trends and topics of contemporary Ghazal are being reformed by the same resultant same social issues or conditions which are found in the classical Ghazal.
08. New Education Policy 2020 and the Curriculum of BS Urdu
Authors: Dr. Salma Aslam Dr. Muhammad Hamid,
Published: December 2021

BS is the main phase of Pakistan’s education system. Major portion of the higher education-seeking students reach this level of education. That is why, it carries much importance in the system. Its curriculum is going under continuous observation and consequent changes. Curriculum of BS Urdu also underwent three times changes since 2009. The curriculum was first developed by HEC in 2009. It was modified and updated in 2013. “The Undergraduate Education Policy 2020” is the latest document in this connection.  The policy was issued to update the curriculum and conform it to the modern world needs. Practical and Job-oriented approach is the main focus of this policy which reflects in the nine weeks compulsory Standard Internship and entrepreneurship. In this article, the major changes and modifications suggested through this policy have been analyzed and the subsequent conclusion and recommendations have been presented.
10. Muqadamat e Bagh o Bahar: A Critical Debate And Analytical Comparison
Authors: Zeenat un Nisa Ch. Dr. Rahmat Ali Shad,
Published: December 2021

“Muqadamat e Bagh o Bahar” is a supplying scholarly achievement by Dr. Aslam Aziz Durrani. In the beginning of this book, scholarly essay titled as “Pesh Muqadamat” has been presented which includes the artistic aspects etymology, language and analytical comparison of these Muqadamat. Dr Aslam has very artistically put together the analytical views of nine Muqadama Nigars including Mir Aman Dehlvi, John Gilchrist, Molvi Abdul Haq, Mumtaz Hussain, Waqar Azeem, Abul Khair Kashfi, Dr. Mumtaz Manglori, Dr. Saleem Akhtar and Rasheed Hassan Khan. He has done literary postmortem of these Muqadamat so skilfully that the real face of “Bagh o Bahar” is unveiled. The last Muqadama of the said book has been composed by himself which is a vital proof of his love for Muqadma nigari and his grip on the subject.
Event and Entity Coreference Across Five Languages: Effects of Context and Referring Expression
Authors: Bevacqua Luca , Loáiciga Sharid , Rohde Hannah , Hardmeier Christian
Published: December 2021

Current work on coreference focuses primarily on entities, often leaving unanalysed the use of anaphors to corefer with antecedents such as events and textual segments. Moreover, the anaphoric forms that speakers use for entity and non-entity coreference are not mutually exclusive. This ambiguity has been the subject of recent work in English, with evidence of a split between comprehenders' preferential interpretation of personal versus demonstrative pronouns. In addition, comprehenders are shown to be sensitive to antecedent complexity and aspectual status, two verb-driven cues that signal how an event is being portrayed. Here we extend this work via a comparison across five languages (English, French, German, Italian, and Spanish). With a story-continuation experiment, we test how different referring expressions corefer with entity and event antecedents and whether verbal features such as argument structure and aspect influence this choice. Our results show widely consistent, not categorical biases across languages: entity coreference is favoured for personal pronouns and event coreference for demonstratives. Antecedent complexity increases the rate at which anaphors are taken to corefer with an event antecedent, but portraying an event as completed does not reach statistical significance (though showing quite uniform patterns). Lastly, we report a comparison of the same referring expressions to refer to entity and event antecedents in a trilingual parallel corpus annotated with coreference.Together, the results provide a first crosslingual picture of coreference preferences beyond the restricted entity-only patterns targeted by most existing work on coreference. The five languages are all shown to allow gradable use of pronouns for entity and event coreference, with biases that align with existing generalizations about the link between prominence and the use of reduced referring expressions. The studies also show the feasibility of manipulating targeted verb-driven cues across multiple languages to support crosslingual comparisons.
Clinical-epidemiological aspects of acute coronary syndrome in the morbidity and mortality in the Republic of Moldova
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Coropceanu Iana , Ciobanu Gheorghe ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: December 2021

Background: Acute coronary syndrome (ACS) is associated with high costs of hospital care, frequent recurrences and high risks of sudden death and short-term mortality. Material and methods: The retrospective study was based on the evaluation of 140 patients who met the ACS criteria. Clinical and epidemiological data were obtained based on the analysis of statistical reports of the Ministry of Health during 2016-2020. Results: The mean age of the patients was 65.0 ± 27.7 years. Incidence of acute myocardial infarction (AMI) in the population increased from 4.7 to 5.2 cases per 1000 inhabitants. The study found the following occurrence of risk factors: history of cardiovascular disease – 42 (91.3 %) patients, hypertension in 35 (76.1%), obesity in 21 (45.6%), diabetes mellitus in 14 (30.4%) and smoking in 13 (28.3%). The share of risk factors in the male group was distributed as follows: history of cardiovascular disease – 82 (87.2%) patients, hypertension – 63 (67.1%) patients, smoking – 40 (42.5%) patients, diabetes mellitus – 27 (28.7%) patients and obesity was established in 24 (25.5%) of men. Conclusions: ACS affects men more frequently, compared to women, in a ratio of 2.04:1. People under the age of 65 years constitute 57.5%. The results of the study showed that compared to men, women with ACS were older and had significantly more comorbidities.
The use of the constrained prosthesis in the difficult primary knee arthroplasty
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Iacubitchii Vitalie , Betisor Alexandru ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Erhan Nicolae ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: December 2021

Background: The constrained knee prosthesis has the basic indication in revision arthroplasty, but the latest literature reveals that it takes place also in primary total knee arthroplasty in cases of knee osteoarthritis associated with major deformities. Material and methods: Present study is based on the surgical treatment, using the constrained knee prosthesis in the primary total knee arthroplasty, during 2019-2021, of 28 patients with knee osteoarthritis associated with severe deformities in varus or valgus, in the Big Joint Replacement Department, Clinical Hospital of Traumatology and Orthopedics, Chisinau. Results: In this study, the following criteria were evaluated: the type of deformity – valgus (10 cases) and varus (18 cases); the degree of deformation – for varus knees was on average 300 , and for valgus knee – 250 ; bone attrition – 11 cases with bone defects where it was necessary to use augmentations; affected side – in 19 cases the right knee was affected and 9 cases the left one; the women/men ratio was 4/1; the mean age of the patients was 67.5 years; average duration of the intervention – 140 minutes; in 5 cases a lateral para-patellar approach was performed, of which 2 cases with tibial tuberosity osteotomy; complications – 1 case with intra-operative periprosthetic fracture and 2 cases with superficial infections of the operated joints. Conclusions: Osteoarthritis of the knee progresses rapidly, leading to severe deformities, significant bone defects and joint instability, which are indications to use the constrained prosthesis in the primary total knee arthroplasty, long-term follow-up is necessary to obtain the last conclusion, but from this study the constrained knee prosthesis like primary implant for special indication had promising results.
The effect of diabetes mellitus on evolution and outcome of tuberculosis in a prospective study
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Malic Alina , Lesnic Evelina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: December 2021

Background: In the Republic of Moldova almost 5% of the cases with tuberculosis are diagnosed annually among diabetic patients. The aim of this study was to assess the impact of diabetes mellitus on the evolution and anti-tuberculosis treatment effectiveness in a prospective study. Material and methods: A prospective, longitudinal and case-control study, which included a total number of 252 patients diagnosed with pulmonary tuberculosis and distributed in a study group, consisting of 93 patients diagnosed with diabetes mellitus and a control group, consisting of 159 patients without glycemic disorders, was performed. Results: This study identified that one half of the group with diabetes was detected by active screening and one third received anti-tuberculous treatment before actual episode. A similar rate of diabetic and non-diabetic patients was microbiologically positive, as well confirmed with drug-resistance. The anti-tuberculous treatment effectiveness was lower in diabetic patients, the death rate and the low treatment outcome (lost to follow-up and failed) were higher than in non-diabetic patients. The main causes of unfavorable evolution were: glycemic disorders (hyperglycemia), diabetes complications and the history of the anti-tuberculous treatment in the anamnesis. Conclusions: The individualized approach and a tight follow-up should be performed regularly in all patients with glycemic disorders and tuberculosis for the improvement of the disease outcome.
Correlations of myocardial bridges with left ventricle myocardial hypertrophy and prepontin coronary atherosclerosis
Authors:   International Hospital Medpark, Republic of Moldova, Tasnic Mihail , Revenco Valeriu ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Catereniuc Ilia ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: December 2021

Background: Of particular interest are the studies researching the correlations of myocardial bridges with hypertrophic cardiomyopathy and correlations of thick myocardial bridges with the development of coronary atherosclerosis in the proximal to the bridge arterial part. Material and methods: Assessment of the correlation between myocardial bridges, coronary atherosclerosis, and the degree of hypertrophy of the left ventricle was performed by retrospective analysis of 6168 coronary angiography protocols (2012-2019) and echocardiographic data from patients’ clinical records. Results: Moderate systolic compression predominated, and the number of patients detected with severe under the bridge systolic coronary stenosis was double as in patients with nonsignificant coronary atherosclerosis. From the total number, patients with myocardial hypertrophy and myocardial bridges were twice less when compared with the patients with the normal myocardial thickness. The comparative research did not show any interdependence between the degree of vascular compression and the degree of left ventricular myocardial hypertrophy. Proximal to the bridges atherosclerosis was detected in 32% of cases without correlation with the force of the myocardial bridge. Conclusions: The study showed the absence of the correlation between the degree of arterial stenosis caused by the bridge and the degree of hypertrophy of the ventricular myocardium as well as the degree of proximal to the bridge atherosclerosis. Important finding was that the degree of coronary systolic compression is higher in patients with moderate and severe proximal to the bridge atherosclerosis.
The peculiarities of patients with COVID-19 infection
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Ungurean Andrei , Malic Alina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Osipov Tatiana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Lesnic Evelina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: December 2021

Background: The surge demand and decreased availability of the health workers determined the designation of the Clinical Municipal Hospital of Phthisiopneumology (CMHP) into a hospital for the case-management of COVID-19 patients during the period of December 2020 – April 2021 for the treatment of the mild cases. The aim of the study was to assess the main peculiarities of the patients with COVID-19 through a cross-sectional study developed during the period February-April 2021 in the CMHP. Material and methods: A cross-sectional, analytical and prospective study was realized, which included 145 patients with COVID-19 hospitalized in the CMHP during February-April 2021. The inclusion criteria were: patient older 18 years, COVID-19 infection diagnosed by the pulmonologist with the positive polymerase chain reaction result for SARS-CoV-2 (COVID-19) and signed informed consent. Results: The peculiarities of patients with COVID-19 were dominated by the female sex, age over 60 years, residence in the urban districts of Chisinau and the infection acquired in the Republic of Moldova. Common clinical manifestations were: high temperature, profuse sweats, asthenia and headaches, productive cough, dyspnea, loss of smell or taste, and sore throat. The typical radiological findings such ground-glass pattern or consolidation with bilateral multifocal involvement were most frequent. Were cured most of the patients and the death rate was low. Conclusions: Peculiarities and clinical manifestations of the patients admitted in CMHP were typical for the COVID-19 infection. These findings did not show the real outcome of the standard case-management of the COVID-19 due to the restricted admission criteria
Endourological treatment of non-muscular-invasive bladder tumors
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Vladanov Ivan
Published: December 2021

Background: Transurethral resection of the bladder is one of the essential methods in the diagnosis, treatment and management of non-muscularinvasive bladder cancer. The purpose of the procedure is to remove completely all visually detected tumors with a following establishment of a very precise histological diagnosis. The aim of the study is to compare the results of conventional transurethral endoscopic treatment and the En-bloc resection method using different types of energy sources in the treatment of bladder tumors. Material and methods: A total number of 88 patients underwent endourological interventions. Regarding the distribution, 23 patients had conventional transurethral resection, 22 – En-bloc monopolar resection, 21 – En-bloc bipolar resection and 22 – En-bloc with Thu:YAG laser. Clinical data, intraoperative and postoperative data and also the histopathological examination results were compared. Results: The compared groups were heterogeneous by age, sex, tumor characteristic (size, number, location). No significant differences were observed during the operations, comparing the intraoperative and postoperative complications of the studied groups. The detrusor musculature was detected in 74% of cases after conventional transurethral resection, in 91% of cases of En-bloc monopolar resection, in 95% of cases of En-bloc bipolar resection and in 96% of cases of En-bloc Thu:YAG laser. Conclusions: The En-bloc resection technique of non-muscular-invasive bladder tumors is a safe and effective method comparing with the conventional transurethral resection; it allows more favorable postoperative results and obtaining better quality tumor samples which allow establishing correct diagnosis of the disease.
Treatment approaches of electrical injuries
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Taran Anatolie
Published: December 2021

Background: The purpose of this study was to explore the differences in prehospital care, admission characteristics, burn intensive care, surgery and outcomes in patients requiring admission to a burn intensive care unit. Material and methods: The study was conducted on a group of 31 patients, who were hospitalized within the Clinical Hospital of Orthopedics and Traumatology in the period 2015-2019. The data analysis was carried out on the applied method of surgical treatment, the associated postoperative complications, antibiotic therapy applied, etc. Results: 27 out of the total number of patients underwent necrectomy and extensive wound debridement surgery in the first hours upon admission. 14 patients required additional decompression incisions in the underlying skin and fascia. 4 patients out of the total number presented visible signs of carbonization on the affected areas upon admission, therefore they were subjected to an emergency amputation. Out of 27 patients classified as “delayed emergency” cases, 13 patients were subjected to amputation of the corresponding segments. Conclusions: Electrical injuries are a severe cause of disability, as well as a challenging issue for reconstructive surgery, which is concerned with restoring the damaged structures with prosthetic amputation abutments, therefore improving the aesthetic and psychological appearance of the patients.
The incidence of uterine abnormalities
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Toncoglaz Constantin , Toncoglaz Serghei ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Toncoglaz Alina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: December 2021

Background: Congenital uterine abnormalities result from abnormal formation, fusion or resorption of the Mullerian ducts during fetal life. These abnormalities have been associated with an increased rate of miscarriage, preterm birth, and other fetal adverse outcomes. Material and methods: Was performed a clinical observational retrospective study of uterine malformations, diagnosed in the Republic of Moldova. Pelvic MRI (1.5-3 tesla) with contrast and without were examined, from 01.01.2016 to 20.11.2016. During this time, 190 MRIs were performed according to the program, 167 MRIs were included in the study, 23 MRIs were excluded, having total or partial hysterectomy performed. The age of the examined persons is between 81 years and 6 months. Results: 15 uterine malformations were detected, which represent 11.13%. Among the uterine abnormalities were detected 6 cases of bicorn uterus, 3 cases of didelph uterus, 2 cases of uterine agenesis and septate uterus and one case of arcuate uterus, and unicorn. Conclusions: In this study it was determined that the prevalence of uterine malformations in an unselected population in the Republic of Moldova is 11.13%, and that of the septate uterus is 1.2%, data that are similar and correspond to the international literature.
Clinical and imaging interrelationships in the diagnosis of foreign body aspiration in children
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Rotaru-Cojocari Diana , Rascov Victor ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Selevestru Rodica ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Sciuca Svetlana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: December 2021

Background: Foreign body aspiration (FBA) is a typical occurrence in children. The clinical signs are influenced by various causes, and the differential diagnosis is important, especially when the suffocation crisis is not recognized. The aim of this study was to evaluate the clinical and imaging symptoms in children with FBA. Material and methods: A retrospective study is provided of 156 children who were hospitalized and examined (clinical and paraclinical tests) in the Pneumology Clinic between 2011 and 2020 after having a foreign body removed from their airways, using rigid tube bronchoscopy or fibrobronchoscopy. Results: The most affected age group was 1-3 years, which constituted 77.6% (95% CI 70.2% -83.8%). The most common symptoms were: cough – 98.7% (95% CI 95.4%-99.8%), dyspnoea – 94.2% (95% CI 89.3%-97.3%), wheezing – 61.5% (95% CI 53.4%-69.2%). Chest radiography was relevant for foreign body aspirations in 55.8% of cases (95% CI 47.6%-63.7%). The foreign body was extracted from the right bronchus in 32.1%, from the left bronchus in 21.8% of cases, from the lobar / segmental bronchi – 22.5%, and in 21.2% – multiple locations. The etiological structure of the endobronchial foreign body was dominated by the organic ones – 96.8%. Conclusions: Cough, dyspnoea, and wheezing are suggestive of this pediatric emergency. Chest radiography provides diagnostic information only for every second child.
Assessment of teachers' health in relation to working conditions
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Cheptea Dumitru
Published: December 2021

Background: Teaching in schools has been defined as the profession with the most diverse risk factors that affect health. With almost 48000 people currently working in educational institutions, teachers make up the largest occupational group in the Republic of Moldova. Material and methods: The study involved 519 teachers from pre-university educational institutions. For the self-assessment of the health status, a questionnaire was created which was applied online. The subjective assessment was performed by researching the entries in the medical cards. Results: The majority of respondents were women (91.4%), with a mean age of 45.6±7.5 years and a working experience of 22.9±3.2 years. In 75.7% of them health is satisfactory, only 3% have serious health problems and would require hospitalization. In 35.8% of cases, the presence of chronic diseases is registered, their top being led by diseases of the gastrointestinal tract (33.8%), the cardiovascular system (29.2%) and endocrine (27.2%). The most common risk factors mentioned were: high levels of stress (53.5%); increased number of tasks (23.4%); lack of support from family and colleagues (22.9%). Conclusions: The health of teachers is influenced by a variety of risk factors. There were no correlations between the type of institution and the subject taught, which highlights the importance of studying the influence of factors in the occupational environment and the development of prevention measures.
Impact of targeted treatment in non-Hodgkin’s lymphoma with primary lymph node involvement
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Tomacinschii Victor , Robu Maria ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Buruiana Sanda ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Finciuc Veronica ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Grecu Ana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Dudnic Cristina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Urescu Dumitrita ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Suschevici Marina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: December 2021

Background: Non-Hodgkin’s lymphomas (NHL) are malignant tumors that develop from lymphoid tissue. Primary lymph node (LN) involvement is the most common localization (52-70%). The integration of Rituximab (R) in the NHL treatment represented a turning point. The aim of this study was to evaluate the therapeutic impact of the use of R in combination with conventional polychemotherapeutic (PChT) in the treatment of nodal onset NHL. Material and methods: A descriptive cohort study was performed on 80 patients diagnosed with NHL. Results: In the study participated: men – 39(48.8%), women – 41(51.2%). The mean age of the patients was 56.09 ± 13.6 years. The onset of NHL occurred in peripheral l/n in 85.0% of cases, in mediastinal LN – 7.5%, and abdominals in 7.5%. Stages I-II were identified in 21(26.2%) patients, stages III-IV in 59(73.8%) cases. Aggressive NHLs were diagnosed in 54(67.5%) patients, indolent NHLs in 26(32.5%) cases. In 61(76.3%) patients, first-line R+PChT treatment was applied – group 1(G1), and in 19(23.8%) cases conventional PChT was applied – group 2(G2). The overall response rate (ORR) in G1 was 86.8%, in G2 – 63.1%. Complete remissions (CR) were obtained in G1 in 63.9% of patients, in G2 – 47.3% of cases. Progression-free survival (PFS) in G1 had a median of 20 months, and in G2 the median was 12 months (p <0.05). Conclusions: The use of Rituximab increased the ORR rate (86.8% vs 63.1%), the frequency of CR (63.9% vs 47.3%) and PFS (20 months vs 12 months (p <0.05).
First manifestation and evolution of early left ventricular dysfunction in children with Duchenne muscular dystrophy
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Rodoman Iulia , Dorif Alexandr ,   Institute of Mother and Child, Republic of Moldova, Palii Ina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Sacara Victoria ,   Institute of Mother and Child, Republic of Moldova
Published: December 2021

Background: Standard pediatric cardiology examinations and echocardiography fail to discover when the cardiomyopathy will occur in patient with Duchenne muscular dystrophy (DMD). Noninvasive markers are needed to fill this gap. Material and methods: This cohort study included a total number of 30 children (21 children (70%) with DMD and 9 (30%) healthy children. Blood samples were used for biochemical (level of creatine kinase, creatine kinase-MB, lactate dehydrogenase) and miRNA (presence of miR133a 3p, miR133b 3p, miR206 3p, miR208a 3p, miR208b 3p) analysis. All patients underwent partial conventional echocardiography ECOCG and Speckle Tracking. Results: The children in the working group presented compared to healthy children: FCC values increased by 15 (71%) vs 2 (22%), high levels of CK, CK-MB, LDH, which is characteristic for the disease and reflects its stage. Also, there is a decrease in systolic function indicators in the working group: mean FE 59 ± 3.8 %, and GLS: -16.2 ± 3.1%. MiRNA analyses confirmed the presence of miR133a 3p, miR133b 3p, miR206 3p, miR208a 3p, miR208b 3p in both working and control group. Conclusions: For the first time in the Republic of Moldova, we developed and adapted protocols for RNA extraction from human blood, performing screening of specific miRNA in the serum of patients with DMD and healthy children. Also, altered LV strain notwithstanding a normal or mildly modified LVEF represents an essential viewpoint for prospective pediatric drug trials in DMD-related cardiomyopathy prevention.
Erythrocytic antioxidant system in the administration of new coordination compounds thiosemicarbazide derivatives
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Pantea Valeriana , Gamaniuc Marina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Popa Veaceslav ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: December 2021

Background: Currently, there is a growing interest in new local coordination compounds (CC), which demonstrated antitumor properties, but their influence on the erythrocyte antioxidant system has not been studied. The aim of the study: to study the effects of CC, thiosemicarbazide derivatives –TIA-160, CMT-67 and CMJ-33 on indices of the antioxidant system indicators in erythrocytes peripheral blood in vivo experiments. Material and methods: The action of CC on superoxide dismutase, catalase, total antioxidant capacity was evaluated on a group of 34 white rats, randomly divided into 4 groups: the first control group was injected subcutaneously with saline. The other groups (2 – TIA-160, 3 – CMT-67 and 4 – CMJ-33) were given subcutaneously 3 times a week for 30 days, 0.1µM / kg CC. Results: It was established that the TIA-160 compound demonstrated the highest capacity to induce the expression of erythrocyte catalase that exceeded the control level of 1.8, which did not correlate with the enzymatic superoxide dismutase (SOD) activity. Thus, this study showed that there are differences in the mechanisms of action of thiosemicarbazone derivatives. Conclusions: The influence of tested CC on the indices of the antioxidant system is selective. This selectivity may be the base to their strong selective antiproliferative and cytotoxic action on tumor cells, but not on healthy ones.
On Budget Deficit under Economic Growth: Towards a Mathematical Model of MMT
Authors: Tanaka Yasuhito
Published: December 2021

Recently, a school of thought called Modern Monetary Theory (MMT) has been attracting attention, but it has not received much theoretical or mathematical analysis. In this paper, we examine the theoretical validity of the MMT argument using an overlapping generations (OLG) model that includes economic growth due to population growth, and give a generally positive evaluation of MMT. The basic idea is that a certain level of continuous budget deficit is necessary to maintain full employment when the economy is growing, that inflation occurs when the budget deficit exceeds that level, that a recession occurs when the budget deficit falls below that level, and involuntary unemployment occurs. In order to recover from a recession, a budget deficit in excess of that level is required, and that deficit need not be covered by a future budget surplus. The same can be said for growth resulting from technological progress.
Is “sustainability” still relevant to food systems, or do we need a new term?
Authors: Anderson Molly
Published: December 2021

I looked forward to reading the Routledge Hand­book of Sustainable and Regenerative Food Systems because I greatly respect the work of its editors and wanted to know how they would organize such a vast topic. It hardly needs repeating that today’s dominant industrialized food system is destroying biodiversity, degrading soil and water, emitting greenhouse gases, creating products that cause diet-related diseases, erasing traditional farm livelihoods, and destroying farm communities. Despite ample documentation of the problems and wide agreement on their existence, the solu­tions are much more contentious. What are the alternatives to the destructive industrialized food system, and what is the best trajectory from current practices to a better future? I hoped that this book would provide solid answers. . . .
Prediction Model of Soil Electrical Conductivity Based on ELM Optimized by Bald Eagle Search Algorithm
Authors:   Wuhan University, Huang Ying , Jiang Hao ,   Wuhan University, Wang Weixing ,   South China Agricultural University, Sun Daozong ,   South China Agricultural University
Published: December 2021

Soil electrical conductivity is one of the indispensable and important parameters in fine agriculture management, and a suitable soil electrical conductivity can promote good plant growth. Prediction model of soil electrical conductivity is constructed to effectively obtain the conductivity values of soil, which can provide a reference basis for irrigation and fertilization management and prediction evaluation in fine agriculture. Prediction model of soil electrical conductivity based on extreme learning machine (ELM) optimized by bald eagle search (BES) algorithm is proposed in this paper. In the prediction model, the input weights and bias values of the ELM network were optimized using the BES algorithm, and the performance of the model was evaluated with parameters such as mean square error (MSE), coefficient of determination (R^2). Also, the correlations of parameters such as soil temperature, moisture content, pH, and water potential in the soil conductivity prediction model were determined using the exploratory data analysis (EDA) and HeatMap heat map tools. Finally, the proposed model was compared with back propagation neural network (BP), radial basis function networks (RBF), support vector machine (SVM), gated recurrent neural network (GRNN), long short-term memory (LSTM), particle swarm algorithm (PSO) optimization ELM, genetic algorithm (GA) optimized ELM prediction model. The experimental results showed that MSE, R^2 of the proposed model are 4.09 and 0.941, which are better than the other models. Also the results verified the effectiveness of the proposed method, which is a feasible prediction method to guide the irrigation and fertilization management in fine agriculture, because of its good prediction effect on soil conductivity.
A Current Mode Universal Filter and a Single Resistance Controlled Oscillator Employing only Grounded Passive Elements: Applications of VDCC
Authors:   National Institute of Technology Uttarakhand, Singh Arora Tajinder
Published: December 2021

This research article explores the possible applications of voltage differencing current conveyor (VDCC), as a current mode universal filter and a sinusoidal oscillator. Without the need for an additional active/passive element, a very simple hardware modification makes it a dual-mode quadrature oscillator from the filter configuration. Both the proposed circuit requires only two VDCC and all grounded passive elements, hence a preferable choice for integration. The filter has some desirable features such as availability of all five explicit outputs, independent tunability of filter parameters. Availability of explicit quadrature current outputs, independence in start and frequency of oscillations, makes it a better oscillator design. Apart from prevalent CMOS simulation results, VDCC is also realized and experimentally tested using the off-the-shelf integrated circuit. All the pen and paper analysis such as non-ideal, sensitivity and parasitic analysis supports the design.
İbn Kuteybe ve Garîbu’l-Hadîs Alanındaki Çalışmaları
Authors: AKYÜREK Remzi , UYLAŞ Sait
Published: December 2021

Hz. Peygamber’in hadisleri, İslâm’ın Kur’ân’dan sonraki ikinci kaynağı sayılmaktadır. Dinimizle ilgili birçok hüküm ve bilgiler detaylı olarak Kur’ân’da değil de hadislerde yer almaktadır. Bu hadislerde de birçok garip ve nâdir kelime geçmektedir. Dolayısıyla bu sözcükleri açıklamayı amaçlayan garîbu’l-hadîs dalı büyük önem kazanmıştır. Bu alana önemli katkılar sunan âlimlerden biri de İbn Kuteybe’dir. Bu çalışmada müellifin çok yönlü kişiliğinin daha iyi anlaşılmasını sağlayan garîbu’l-hadîs konusundaki katkıları ortaya konulmaya çalışılmıştır.
27 Mayıs Darbesi Sürecinde Basında İstanbul-Ankara Öğrenci Olayları
Authors: TOPÇU Sema Akılmak , URAL Selçuk
Published: December 2021

Öz: 18 Nisan 1960’da Tahkikat Komisyonu ve 27 Nisan’da bu komisyona geniş yetkiler tanıyan Salahiyetler Kanunu’nun mecliste kabul edilmesinden bir gün sonra İstanbul ve Ankara’da üniversite öğrencilerinin başını çektiği protesto gösterileri başladı. Demokrat Parti hükümeti tarafından bu iki şehirde sıkıyönetim ilan edilerek sert tedbirler uygulandı. Bu tedbirler kapsamında basına da müdahale edildi ve protestolarla ilgili her türlü haber yapılması yasaklandı. Yasaklara riayet etmeyen gazetelere bir müddet kapatma cezası verilirken, ilgili nüshaları toplatıldı. Bu nedenle 27 Mayıs darbesine kadar dönemin gazetelerinde İstanbul ve Ankara’daki olaylarla ilgili haberlere rastlamak adeta imkânsızdır. Darbeden sonra cuntacılar müdahalenin meşruiyetini kamuoyuna anlatmak için DP iktidarını akıllara durgunluk veren suçlamalarla itham etmeye başladılar. İstanbul-Ankara olaylarında çok sayıda öğrencinin hükümet tarafından canice öldürüldüğü, cesetlerinin yem makinalarında kıyılıp toz haline getirildiği iddiaları basında geniş yer buldu. Hatta dönemin gazeteleri hayatını kaybeden öğrenciler adına anıt yapılması için kampanyalar başlattılar. Harp Okulu öğrencilerinin ortadan kaldırılması için planlar yapıldığı, gömülmüş silah ve askeri malzemeler bulunduğu gibi iddialara da dönemin gazetelerinde rastlanmaktadır.
Okul Yöneticilerinin Değişimi Yönetme Yeterlikleri ile Algılanan Okul Etkililiği Ne Düzeydedir?
Authors: YÜREK Uğur , CÖMERT Melike
Published: December 2021

Bu araştırmanın temel amacı okul yöneticilerinin değişimi yönetme yeterlikleri ile okul etkililiği arasındaki ilişkiyi incelemektir. Araştırmanın çalışma grubunu 2019-2020 eğitim-öğretim yılında İnönü Üniversitesi Eğitim Yönetimi Tezsiz Yüksek Lisans programına devam eden, ulaşılabilen ve gönüllü 102 yönetici oluşturmaktadır. Çalışmada yöneticilerin değişimi yönetme yeterlik düzeylerini belirlemek amacıyla Helvacı (2004) tarafından geliştirilen “Değişimi Yönetme Yeterlik Ölçeği” kullanılmıştır. Ayrıca, yöneticilerin okul etkililiği algı düzeylerini belirlemek amacıyla orijinali Hoy, Tarter ve Kottkamp (1991) tarafından geliştirilen, Türkçeye uyarlaması Yıldırım (2015) tarafından yapılan “Okul Etkililiği Ölçeği” kullanılmıştır. Ölçeklerden elde edilen verilerin analizinde; normal dağılım gösteren yerlerde parametrik testler, normal dağılım göstermeyen yerlerde ise nonparametrik testler kullanılmıştır. Araştırmadan elde edilen bulgulara göre; okul yöneticileri, “Değişimi Yönetme Yeterlik Ölçeği’nin alt boyutlarından “Okulda Değişim İhtiyacını Belirleme”, “Okulu Değişim Sürecine Hazırlama” ve “Okulda Değişimi Uygulama” boyutlarında “Çok Yeterli” olduklarını ifade etmişlerdir. “Okulda Değişimi Değerlendirme” boyutunda ise “Oldukça Yeterli” düzeyinde olduklarını ifade etmişlerdir. Okul yöneticilerinin algıladıkları okul etkililiğinin ise “Çok Yeterli” düzeyinde olduğu belirlenmiştir. Yöneticilerin değişimi yönetme yeterlikleri ile okul etkililiği arasındaki ilişki incelendiğinde ise aralarında anlamlı, pozitif yönde ve zayıf düzeyde bir ilişki olduğu belirlenmiştir.
Integrating The Mark on the Wall into an EFL Lesson to Teach Reading and Vocabulary
Authors: AYAR Zülal
Published: December 2021

As the literature strikes interest and arouses the curiosity of learners, it is widely acknowledged that it has an undeniable impact on language education. In this sense, a lesson plan was developed focusing on the reading skill and vocabulary, and aimed at getting learners to discuss and make a critical analysis of a story. Accordingly, Virginia Woolf's one of the well-known short stories, ‘The Mark on the Wall’ was incorporated into the plan as an extensive reading resource. In light of constructivism theory and eclectic method, this plan was designed for the instructors teaching English to learners enrolled in the English philology department and taking one-year compulsory preparatory education at schools of foreign languages. As it is grounded upon synchronization, orchestration and symbiotic existence of the language teaching techniques, this short course plan would stimulate students’ self-discovery, creativity, learner-centeredness, and reading analyses via pair-work and group activities.
Changing national health values of Russian youth aged 13-17
Authors: Fomicheva T. V. , Dolgorukova I. V. , Sulyagina J. O. , Kryukova E. M. , Filimonova N. N. , Zhukova V. I.
Published: December 2021

The article is devoted to the study of the attitudes of contemporary Russian youth to a healthy lifestyle, healthcare in general, and physical culture and sports. As a result of a qualitative sociological study, the main trends and perspectives in the perception of a healthy lifestyle, physical culture, and sports in Russian regions are discovered and defined. The study specifies the motivational aspects of young Russians’ attitudes to a healthy lifestyle, healthcare, physical culture, and sports. The specific features of the development of regional physical culture and sports in Russia, as well as the characteristics of the perception of physical culture and sports by various groups of Russian youth in the regions of the country, are identified. The attitudes to social stereotypes concerning a healthy lifestyle and sports in the minds of Russian citizens are discovered. The practical significance of the study results: the conclusions of the project can be used for the development of youth policy, as well as the development of new programs for the optimization of young people’s lifestyle and the development of physical culture and sports in Russia. The study results can be utilized for the innovation of courses on the sociology of health and disease.
Early postoperative complications in patients with acute myocardial infarction during emergency coronary bypassing
Authors: Todurov Borys , Bitsadze Alexander , Shorikova Dina
Published: December 2021

The article aims to determine the factors of early mortality in emergency coronary artery bypass grafting. Research methods. The research were included 129 patients who were hospitalized in Kyiv “Heart Center” in 2011-2015, 100 – with ST-elevated myocardial infarction, 29 – with non- ST-elevated myocardial infarction (NSTEMI). Research results. In STEMI patients vs. NSTEMI type was a higher risk of acute heart failure (p<0.05) followed by intra-aortic balloon pulsation (p<0.05) and inotropic support (p<0.05). In the STEMI group acute kidney injury was confirmed by higher indexes of absolute and relative risks (p<0.05). All cases of the transient atrioventricular block were registered in patients with STEMI (p<0.05). However, it was established that the likelihood of supraventricular arrhythmia and encephalopathy in the NSTEMI group was reliably higher (p<0.05). The level of early postoperative mortality (12.4%) proved the probable risk (p<0.05) in STEMI (log-rank - 2,74; p = 0,006). Mortality was associated with acute heart failure (56,2%), cardiogenic shock (31,3%), acute mitral regurgitation (12.5%). Emergency surgical revascularization in acute MI is an effective method of treatment and can be used taking into account clinical, hemodynamical, and coronary features of myocardial damage.
Koramaz Vadisi (Kayseri) ve Çevresinin Makrofungusları
Authors: ALLI Hakan
Published: December 2021

Koramaz Vadisi (Melikgazi, Kayseri, Türkiye) ve çevresinde farklı lokalitelerden 2019 ve 2020 yıllarında 64 makrofungus örneği toplanmıştır. Arazi ve laboratuvar çalışmaları sonucunda, 2 bölüm ve 17 familyada dağılım gösteren 36 takson belirlenmiştir. Morchellaceae (4), Hymenochaetaceae (4) ve Polyporaceae (4) en fazla takson içeren familyalardır. Bu taksonlardan Entoloma alpicola ülkemizde ilk kez tanımlanmış ve Türkiye Mikotası için yeni kayıt olarak rapor edilmiştir. E. alpicola türüne ait örneklerin şekilleri ile birlikte kısa tanımı, lokaliteleri, toplama tarihleri, ekoloji ve dağılımları verilmiş ve kısaca tartışılmıştır.
Bal Arıları (Apis mellifera) İçin Yozgat Florasındaki Önemli Bitkiler
Authors: TAŞTAN Fatih
Published: December 2021

Bu araştırmada, Yozgat ilindeki hayvansal üretimlerden olan arıcılık faaliyetinde önem arz eden nektar ve polen bitkileri hakkında bilgiler sunulmuştur. Çalışma kapsamında Yozgat ili civarında ballı bitkilerin belirlenmesi, tanıtılması ve arıcılık açısından floristik zenginliğin ortaya konulması amaçlanmıştır. Konuyla ilgili yapılan çalışmaların incelenmesi sonucunda bal arısının (Apis mellifera) faydalanabileceği 45 familyaya ait 531 bitki taksonu belirlenmiş, belirlenen taksonların bilimsel ve Türkçe isimleri, yetişme ortamları ve arılar için önem teşkil eden aktif çiçeklenme zamanları verilmiştir. Belirlenen taksonların familyalara dağılımına göre; en fazla takson içeren ilk üç familya Fabaceae (104 takson), Asteraceae (72 takson) ve Lamiaceae (67 takson)’dir. Ayrıca nektar ve polen kaynağı olarak kullanılabilecek 531 bitki taksonundan 84 adedinin endemik olduğu saptanmıştır.
An Investigation of the Relationship between University Students' Digital Burnout Levels and Perceived Stress Levels
Authors: GÖLDAĞ Battal
Published: December 2021

The aim of this study is to examine the relationship between university students' digital burnout levels and their perceived stress levels. The population of the research consists of students studying at İnönü University, Malatya, in the spring semester of the 2020-2021 academic year. The data were collected online. The sample included 925 students who voluntarily participated in the research. According to the results obtained in the research; students' digital burnout levels are above average and their perceived stress level is moderate. Students who use smart phones to connect to the Internet have higher levels of digital burnout than those who use desktop/laptop. The digital burnout levels of students studying at undergraduate level are higher than students studying at graduate level. There is no difference between students' digital burnout levels and perceived stress levels according to the classes they study and the level of use of digital devices. As students' internet usage time increases, their digital burnout levels and perceived stress levels also increase. There is a moderately positive and significant relationship between students' digital burnout levels and their perceived stress levels. As students' digital burnout levels increase, so do their perceived stress levels.