bluuebunny/crossref_metadata_2025 huggingface dataset:
Cabo Verde’s Poaceae Flora: A Reservoir of Crop Wild Relatives Diversity for Crop Improvement
Authors: Rocha Vanézia , Duarte Maria C. , Catarino Silvia , Duarte Ivani , Romeiras Maria M.
Published: February 2021

Africa is home to important centers of origin and diversity of crop wild relatives (CWR), including many species adapted to adverse agroecological conditions, namely drought and poor soils. Plant genetic resources from Cabo Verde Islands have been poorly explored for their potential to supplement the genetic pool of cultivated species. In this paper we identify Cabo Verde’s CWR from the Poaceae family and provide a checklist of priority CWRtaxa, highlighting those of particular conservation concern and the areas which should be the focus of the most intensive conservation efforts in these islands. Our results revealed that Cabo Verde archipelago is an important center of CWR diversity of West African crop millets, namely fonio (e.g., white fonio,Digitaria exilis, and black fonio,Digitaria iburua) and other African millets [e.g., pearl millet (Cenchrus americanus=Pennisetum glaucum), teff millet (Eragrostis tef), finger millet (Eleusine coracana), barnyard millet (Echinochloa colona), proso millet (Panicum miliaceum), and foxtail millet (Setaria italica)], which represent a diverse group of cereal crops, and important components in agriculture and food security of this country. Also, hotspot areas of diversity forin situconservation were identified in Cabo Verde, as well as several populations occurring under extreme habitats conditions that are well adapted to drylands and poor soils. The evaluation of their potential for new ecologically important adaptive characteristics associated with tolerance to abiotic stresses is discussed. The survey of international Germplasm Banks revealed that very few accessions from Cabo Verde are conserved, contributing to the loss of genetic diversity of plant genetic resources in this archipelago. Particularly, the diversity of millets and the associated indigenous knowledge are critical for the food security and cultural identity of many poor farmers in Cabo Verde.
The Ties That Bind: University Nostalgia Fosters Relational and Collective University Engagement
Authors: Green Jeffrey D. , Cairo Athena H. , Wildschut Tim , Sedikides Constantine
Published: February 2021

Does nostalgia for one’s time at university predict current intentions to engage with the university? In Study 1, United States participants’ nostalgia for their university experience (university nostalgia) at a southern public university predicted stronger intentions to socialize with fellow alumni, attend a future reunion, volunteer for their university, and donate money to their university. Study 2 replicated these findings with alumni from a northeastern private university, and extended them by finding that the links between university nostalgia and university engagement emerged even when controlling for the positivity of university experience. In both studies, feelings of university belonging mediated most of the associations between university nostalgia and university engagement. In Study 2, the positivity of the university experience moderated the relation between university nostalgia and two indices of university engagement. Specifically, university nostalgia was more strongly associated with intentions to attend a reunion and donate money among those who had a relatively negative university experience. Nostalgia for one’s university past predicts future engagement with the university as well as its members.
A Multi-Block Multivariate Analysis to Explore the Influence of the Somatic Maturation in Youth Basketball
Authors: Arede Jorge , Oliveira Irene , Ángel Gomez Miguel-Angel , Leite Nuno
Published: February 2021

The aim of this study was to examine the influence of somatic maturation in anthropometric, physical, and game-related variables in youth basketball age groups under-13 (U-13) and under-15 (U-15). One-hundred and eighty-five basketball players performed anthropometrical and physical tests during a non-official youth basketball tournament. Predicted maturity offset (MO) and game-related variables were also analyzed. Cluster analysis was used to analyze the between-maturation status differences in all parameters in each age group. Also, regularized generalized canonical correlation analysis (RGCCA) was used to assess relative contributions of maturational, physical, and game-related variables within each age group. Based on MO, two different clusters were identified within each age category. Greater differences in MO were identified among U-13 clusters than among U-15 clusters. No significant differences were observed between clusters in terms of physical and game-related variables. High correlations between maturational, physical, and game-related variables (i.e., points scored, field goals attempted, and rebounds) were found for boys. In girls, different trends in terms of correlations were observed. The strongest association between blocks was observed between physical tests and game-related variables in all age categories, except for U-15 girls. Knowing and identifying performance profiles according to biological age is of upmost importance since it allows the coach to create challenging situations adjusted to the individual’s needs.
Low-Intensity Steady Background Noise Enhances Pitch Fusion Across the Ears in Normal-Hearing Listeners
Authors: Oh Yonghee , Lee Sabrina N.
Published: February 2021

Binaural pitch fusion is the perceptual integration of stimuli that evoke different pitches between the ears into a single auditory image. This study was designed to investigate how steady background noise can influence binaural pitch fusion. The binaural fusion ranges, the frequency ranges over which binaural pitch fusion occurred, were measured with three signal-to-noise ratios (+15, +5, and −5dB SNR) of the pink noise and compared with those measured in quiet. The preliminary results show that addition of an appropriate amount of noise can reduce binaural fusion ranges, an effect called stochastic resonance. This finding increases the understanding of how specific noise levels can sharpen binaural pitch fusion in normal hearing individuals. Furthermore, it elicits more pathways for research to explore how this benefit can practically be used to help improve binaural auditory perception.
Strong Associations Between Childhood Victimization and Community Violence in Male Forensic Mental Health Patients
Authors: Fosse Roar , Eidhammer Gunnar , Selmer Lars Erik , Knutzen Maria , Bjørkly Stål
Published: February 2021

Background: Childhood abuse and neglect increase the risk of both mental disorders and violent behavior. Associations between child relational adversities and violent behavior have not been extensively investigated in forensic mental health settings. We asked whether the extent of child adversities predicts the extent of violence in the community in forensic mental health patients.

Methods: We included 52 male patients at a medium security forensic mental health ward, with diagnoses of predominantly paranoid schizophrenia and other schizophrenia and psychotic disorders. Seventy-five percent had comorbid substance abuse. We extracted information on six types of child adversities based on clinicians' administrations of the Historical Clinical Risk Management 20 version 3 (HCR 20) scale and summary notes in electronic patient journals. These same sources were used to extract information on war trauma and interpersonal violence in the community. We established cumulative scales for exposure to number of types of child adversities and number of incidents of community violence.

Results: Physical and emotional abuse, emotional and physical neglect, and bullying were associated with higher levels of community violence. We observed a linear, significant increase in the frequency of community violence with cumulative numbers of child adversity types.

Conclusions: Cumulative exposure to child adversities may be associated with higher degrees of violence in forensic mental health patients, with the most violent patients having the most extensive exposures to adversities. An enhanced focus on child adversities in risk assessment and management of violence may be considered in forensic inpatient settings.
Effects of a Plastic-Free Lifestyle on Urinary Bisphenol A Levels in School-Aged Children of Southern Italy: A Pilot Study
Authors: Sessa Francesco , Polito Rita , Monda Vincenzo , Scarinci Alessia , Salerno Monica , Carotenuto Marco , Cibelli Giuseppe , Valenzano Anna , Campanozzi Angelo , Mollica Maria Pina , Monda Marcellino , Messina Giovanni
Published: February 2021

Bisphenol A (BPA) is an endocrine disruptor (ED) frequently used in food packaging. BPA is used as a monomer in the manufacture of some food packaging. This study aimed to evaluate the urinary BPA concentration in an Italian pediatric cohort, testing the levels of this ED over a period of 6 months, evaluating the effects of a diet regimen with a reduction of Plastic Food Packaging (PFP). One hundred thirty Italian children were enrolled and divided into two groups “School Canteen” and “No School Canteen.” The first group consumed one meal at school using a plastic-free service for 5 days/weeks, while the other group did not modify their normal meal-time habits. The BPA levels were tested in urine samples at three time points: T0, is the time before the application of the plastic-free regimen diet; T3, 3 months later; and T6, 6 months later. A reduction of urine BPA levels was detected in the “School Canteen” group. In particular, the reduction was significant analyzing both the intra (among the three testing times) group and inter (between “School Canteen” and “No School Canteen”) group variability. Our results show the effects of a diet regimen with a reduction of PFP, demonstrating a connection between urinary BPA levels and food packaging.
Precision Regulation Approach: A COVID-19 Triggered Regulatory Drive in South Korea
Authors: Lee Sora , Kang Woojin
Published: February 2021

COVID-19 has triggered various changes in our everyday lives and how we conceptualize the functions of governments. Some areas require stricter forms of regulation while others call for deregulation. The challenge for the regulatory authorities is to manage these potentially conflicting demands in regulation and define coherently their overall regulatory rationale. The precision regulation approach can be a helpful approach. It is defined here as a streamlined approach to regulation to deliver the right methods of regulation for the right group of people at the right time. This problem-solving innovation in regulation triggered by the recent epidemiologic crisis in South Korea demonstrates the emergence of the precision regulation approach. South Korea has implemented streamlined fast-track services for the biotechnology industry to produce test kits swiftly. This article expands the definition of precision regulation from AI regulation literature, and positions the term as a new regulatory rationale, not as a regulatory tool, using the case study from South Korea.
Physical Activity in Crisis: The Impact of COVID-19 on Danes' Physical Activity Behavior
Authors: Schmidt Tanja , Pawlowski Charlotte Skau
Published: February 2021

Objectives: Because of the COVID-19 pandemic, societies have been shut down, changing the lives of citizens worldwide, including their physical activity (PA) behavior. This cross-sectional study aimed to investigate the impact of the shutdown on Danish citizens' leisure PA throughout different stages of life: 15–18, 19–29, 30–59, and 60+ years.

Methods: Between April 3 and 15, 2020, while Denmark was shut down, a survey was distributed through online platforms. Danish citizens (>15 years) could participate in the study, answering questions about their PA behavior before, and during the shutdown.

Results: The number of total participants was 1,802; 7.9% teens, 21.5% younger adults, 58.7% adults, and 11.9% older adults. Mean minutes of PA decreased 16.1% from before to during the shutdown. Teens had the largest decrease in PA (36.6%) followed by older (24.9%) and younger adults (21.3%). Low educated (31.5%) and those living in rural areas (30.9%) experienced the largest decrease in PA. Main factors for not doing PA during the shutdown were that they missed what they used to do, lacked social support, and did not have access to the right facilities.

Conclusions: During the shutdown, the Danish population struggled even more to comply with national PA guidelines compared with before the shutdown. Although social distancing and shutting down sports facilities are important for preventing the spread of the virus, it can have negative consequences for teens' and younger and older adults' opportunities and motivation for PA, leading to an alarming decrease in PA, and, consequently, will have major public health consequences.
Serum Cortisol and Clinical Response to a Single Session of Whole-Body Vibration in Healthy Adult Dogs
Authors: Tannus Filipe C. I. , Rahal Sheila C. , Oba Eunice , Tsunemi Miriam , Silva Bruna M. , Almeida Karina C. , Santos Ivan F. C.
Published: February 2021

This study evaluated the serum cortisol response to a single session of whole-body vibration (WBV) in healthy adult dogs. Ten healthy adult medium dogs, females and males, aged between 24 and 48 months and with body weight between 10.1 and 17.9 kg were used. A single WBV session at a frequency of 30 Hz for 5 min (3.10 mm peak displacement, 11.16 m/s2 peak acceleration, and 0.29 m/s velocity), then 50 Hz for 5 min (3.98 mm peak displacement, 39.75 m/s2 peak acceleration, and 0.62 m/s velocity), and finishing with 30 Hz for 5 min (3.10 mm peak displacement, 11.16 m/s2 peak acceleration, and 0.29 m/s velocity) was performed. Serum cortisol, heart and respiratory rate, and systolic blood pressure were evaluated at different time points: 1 min before WBV (1PRE) and 1 min (1POST), 60 min (60POST), and 360 min (360POST) after the WBV session. An increase (P = 0.0417) of the serum cortisol values was observed between 1PRE and 1POST and a decrease (P = 0.0417) between 1POST and 60POST and between 60POST and 360POST. However, the values remained within the reference range. The heart and respiratory rate and the systolic blood pressure remained unchanged. Our findings suggest that a single bout of WBV (5 min of 30 and 50 Hz) using a vibrating platform that delivered a vortex wave circulation does not modify the serum cortisol levels and clinical parameters of healthy adult dogs.
Acknowledgment to Reviewers of Administrative Sciences in 2020
Authors:   Administrative Sciences Editorial Office
Published: February 2021

Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Administrative Science maintains its standards for the high quality of its published papers [...]
Classification of Lampung robusta Specialty Coffee According to Differences in Cherry Processing Methods Using UV Spectroscopy and Chemometrics
Authors: Suhandy Diding , Yulia Meinilwita
Published: February 2021

The postharvest processing factors including cherry processing methods highly influence the final quality of coffee beverages, especially in the composition of several coffee metabolites such as glucose, fructose, the amino acid (glutamic acid), and chlorogenic acids (CGA) as well as trigonelline contents. In this research, UV spectroscopy combined with chemometrics was used to classify a ground roasted Lampung robusta specialty coffee according to differences in the cherry processing methods. A total of 360 samples of Lampung robusta specialty coffee with 1 g of weight for each sample from three different cherry processing methods were prepared as samples: 100 samples of pure dry coffee (DRY), 100 samples of pure semi-dry coffee (SMD), 100 samples of pure wet coffee (WET) and 60 samples of adulterated coffee (ADT) (SMD coffee was adulterated with DRY and WET coffee). All samples were extracted using a standard protocol as explained by previous works. A low-cost benchtop UV-visible spectrometer (Genesys™ 10S UV-Vis, Thermo Scientific, Waltham, MA, USA) was utilized to obtain UV spectral data in the interval of 190–400 nm using the fast scanning mode. Using the first three principal components (PCs) with a total of 93% of explained variance, there was a clear separation between samples. The samples were clustered into four possible groups according to differences in cherry processing methods: dry, semi-dry, wet, and adulterated. Four supervised classification methods, partial least squares–discriminant analysis (PLS-DA), principal component analysis–linear discriminant analysis (PCA-LDA), linear discriminant analysis (LDA) and support vector machine classification (SVMC) were selected to classify the Lampung robusta specialty coffee according to differences in the cherry processing methods. PCA-LDA is the best classification method with 91.7% classification accuracy in prediction. PLS-DA, LDA and SVMC give an accuracy of 56.7%, 80.0% and 85.0%, respectively. The present research suggested that UV spectroscopy combining with chemometrics will be highly useful in Lampung robusta specialty coffee authentication.
The Agri-Environment-Climate Measure as an Element of the Bioeconomy in Poland—A Spatial Study
Authors: Jezierska-Thöle Aleksandra , Rudnicki Roman , Wiśniewski Łukasz , Gwiaździńska-Goraj Marta , Biczkowski Mirosław
Published: February 2021

The Polish agricultural economy has a chance to dynamically develop and influence the innovation policy in the EU model of bioeconomy. The research aims to assess the spatial diversification of the level and structure of spending funds for two Rural Development Program (RDP) measures: agri-environment-climate measures (AECM) and organic farming scheme (OFS) aimed at supporting proenvironmental forms of agricultural management in the context of bioeconomy development. The EU financial perspective determined the time range for 2014–2020. The study was conducted on the example of Poland in two spatial scales: regional (province) and local (community). The analysis was based on partial indicators, which were then subjected to the standardisation procedure and included in the total as a synthetic indicator of the utilisation of RDP 2014–2020 funds aimed at supporting proenvironmental forms of farming. The following information was included in the evaluation: the number of farms, the size of utilised agricultural area (UAA) covered by support and the amounts of payments made under the two analysed RDP measures. In the research, the size and distribution of farms benefiting from AECM and OFS were determined. Besides, the relationship between funds absorption and socioeconomic development, as well as natural and non-natural conditions, were identified. The synthetic indicator of AECM/OFS usage showed a strong spatial differentiation, determined by the impact of several conditions: the level of socioeconomic development, the level of agriculture development, natural conditions of agriculture, land with significant natural and ecological values, and proenvironmental forms of land use on farms. Spatial diversification is more often the result of the impact of proenvironmental or natural-ecological factors than of socioeconomic conditions, or the level of agricultural development.
Comparison between Dense L-Band and C-Band Synthetic Aperture Radar (SAR) Time Series for Crop Area Mapping over a NISAR Calibration-Validation Site
Authors: Kraatz Simon , Torbick Nathan , Jiao Xianfeng , Huang Xiaodong , Robertson Laura Dingle , Davidson Andrew , McNairn Heather , Cosh Michael H. , Siqueira Paul
Published: February 2021

Crop area mapping is important for tracking agricultural production and supporting food security. Spaceborne approaches using synthetic aperture radar (SAR) now allow for mapping crop area at moderate spatial and temporal resolutions. Multi-frequency SAR data is highly useful for crop monitoring because backscatter response from vegetation canopies is wavelength dependent. This study evaluates the utility of C-band Sentinel-1B (Sentinel-1) and L-band ALOS-2 (PALSAR) data, collected during the 2019 growing season, for generating accurate active crop extent (crop vs. non-crop) classifications over an agricultural region in western Canada. Evaluations were performed against the Agriculture and Agri-Food Canada satellite-based Annual Cropland Inventory (ACI), an open data product that maps land cover across the extent of Canada’s agricultural land. Classifications were performed using the temporal coefficient of variation (CV) approach, where an optimal crop/non-crop delineating CV threshold (CVthr) is selected according to Youden’s J-statistic. Results show that crop area mapping agreed better with the ACI when using Sentinel-1 data (83.5%) compared to PALSAR (73.2%). Analysis of performance by crop reveals that PALSAR’s poorer performance can be attributed to soybean, urban, grassland, and pasture ACI classes. This study also compared CV values to in situ wet biomass data for canola and soybeans, showing that crops with lower biomass (soybean) had correspondingly lower CV values.
Measurement Method for Fluid Pressure Fluctuation in Fluid-Conveying Pipe Using PVDF Piezoelectric Film Sensor
Authors: Liu Song , Wu Xianmei , Kong Yuanyuan , Peng Xiuqian
Published: February 2021

As a representative fluid-transporting system, fluid-conveying pipes play an essential role in many fields. For a fluid-conveying pipe system in operation, fluid pulsation in pipes contains much information about fluid flow parameters (flow velocity, fluid pressure, etc.). Therefore, the measurement of fluid pulsation is important for understanding the internal fluid flow. To use polyvinylidene fluoride (PVDF) piezoelectric film sensors to indirectly measure the pressure fluctuation of the internal fluid, we simulated a fluid-conveying pipe with PVDF piezoelectric film sensors attached to the outer pipe wall. The simulation results showed that the variation of voltage signal of PVDF, circumferential stress and strain of the pipe wall, and the pressure fluctuation of internal fluid were highly positively correlated, which proved that the PVDF piezoelectric film sensor can be applied to indirectly measure the pressure fluctuation of internal fluid. We also studied the influences of flow velocity pulsation and mechanical vibration caused by the pipeline pump during operation. It is found that the flow velocity pulsation had little influence on the measurements of the variation of circumferential stress and strain of the pipe wall and the internal fluid pressure fluctuation. When both ends of the pipe were fixed by hoops, mechanical vibration had little influence on the measurement of the variation of circumferential stress and strain of the pipe wall as well as the fluid pressure fluctuation. Finally, simulation results were verified by experiments.
Cognitive Patterns and Coping Mechanisms in the Context of Internet Use
Authors: Costescu Cristina , Chelba Iulia , Roșan Adrian , Kovari Attila , Katona Jozsef
Published: February 2021

Recent research indicates there are different cognitive patterns and coping mechanisms related to increased levels of Internet use and emotional distress in adolescents. This study aims to investigate the relationship between coping mechanisms, dysfunctional negative emotions, and Internet use. A total of 54 participants aged between 14 and 19 years old completed a questionnaire containing several measures and demographics information. We measured participants’ coping strategies, emotional distress, social and emotional loneliness, and their online behavior and Internet addiction using self-report questionnaires. In order to identify the relation between the investigated variables, we used correlation analysis and regression, and we tested one mediation model. The results showed that maladaptive coping strategies and Internet use were significant predictors of dysfunctional negative emotions. Moreover, passive wishful thinking, as a pattern of thinking, was associated with anxious and depressed feelings. The relation between Internet use and dysfunctional negative emotions was mediated by participants’ coping mechanisms. Therefore, we can conclude that the level of negative feelings is associated with the coping strategies used while showing an increased level of Internet addiction. Future studies should also consider different and multiple types of measurement other than self-reports, especially related to Internet addiction.
Manufacturing Optically Transparent Thick Zirconia Ceramics by Spark Plasma Sintering with the Use of Collector Pressing
Authors: Paygin Vladimir , Dvilis Edgar , Stepanov Sergey , Khasanov Oleg , Valiev Damir , Alishin Timofei , Ferrari Maurizio , Chiasera Alessandro , Mali Vyacheslav , Anisimov Alexander
Published: February 2021

The efficiency of using the collector pressing scheme in the Spark Plasma Sintering (SPS) process has been confirmed in improving the optical, physical, and mechanical properties of yttria-stabilized zirconia (YSZ) ceramics with an increased shape factor. An approach for developing a seal surface and determining the optimal method of increasing pressure and temperature during SPS on this surface was used to optimize the consolidation modes of the materials. It has been shown that transparent/translucent YSZ ceramics with an increased shape factor (14 mm in diameter and up to 5 mm in height, h/d = 0.36) can be successfully fabricated by the SPS technique combined with the collector pressing scheme. The optical properties and microhardness of ceramics obtained using the collector scheme are better to the optical properties of ceramics obtained using the conventional uniaxial pressing scheme.
Local Sensitivity Analysis of Steady-State Response of Rotors with Rub-Impact to Parameters of Rubbing Interfaces
Authors: Jiang Minghong , Zheng Zhaoli , Xie Yonghui , Zhang Di
Published: February 2021

Local sensitivity analysis, which describes the relative importance of specific design parameters to the response of systems, is crucial for investigating dominant factors in optimal design. In this paper, local sensitivity analysis of the response of rotors with rub-impact to parameters of rubbing interfaces is carried out. The steady-state motion of the rotor is evaluated by a harmonic balance method and the sensitivity coefficients for every rotation speed over the speed range are derived analytically. Two classical models, including the Duffing oscillator and the gap model, are utilized to validate the accuracy and capability of the adopted methods and high accuracy is shown. Numerical investigations of sensitivities of steady-state response of rotors to parameters of rubbing interfaces are then carried out, based on a lumped Jeffcott rotor and a finite element model respectively. Conclusions are drawn that the response of rotors subjected to rubbing problems is more sensitive to initial clearance than other parameters of the applied friction model. With increase of initial gap, the response of rotors becomes more sensitive and the range of region subjected to rub-impact forces shrinks until the separation of rotor and stator.
Sentence Representation Method Based on Multi-Layer Semantic Network
Authors: Zheng Wenfeng , Liu Xiangjun , Yin Lirong
Published: February 2021

With the development of artificial intelligence, more and more people hope that computers can understand human language through natural language technology, learn to think like human beings, and finally replace human beings to complete the highly difficult tasks with cognitive ability. As the key technology of natural language understanding, sentence representation reasoning technology mainly focuses on the sentence representation method and the reasoning model. Although the performance has been improved, there are still some problems such as incomplete sentence semantic expression, lack of depth of reasoning model, and lack of interpretability of the reasoning process. In this paper, a multi-layer semantic representation network is designed for sentence representation. The multi-attention mechanism obtains the semantic information of different levels of a sentence. The word order information of the sentence is also integrated by adding the relative position mask between words to reduce the uncertainty caused by word order. Finally, the method is verified on the task of text implication recognition and emotion classification. The experimental results show that the multi-layer semantic representation network can promote sentence representation’s accuracy and comprehensiveness.
Microbial Control by High Pressure Processing for Shelf-Life Extension of Packed Meat Products in the Cold Chain: Modeling and Case Studies
Authors: Katsaros George , Taoukis Petros
Published: February 2021

Vacuum packed Bratwurst type cooked sausages and sliced or cubed meat products that have limited shelf-life of few days in chilled storage were HP processed (5 min, 600 MPa, 25 °C) and stored at different temperatures (0–15 °C). Color, texture, and microbiological and sensory evaluation were kinetically studied for control and HP treated samples. HP treatment did not alter the color and texture of the treated samples when compared to untreated ones. Lactic acid bacteria were found to be the main spoilage index. The rates of microbiological and organoleptic deterioration were estimated, and their temperature dependence was modeled by the Arrhenius equation. An increase of their shelf life of five to eight times was estimated, compared to untreated ones. A sensory survey on HP treated cooked ham showed that the consumers could not distinguish differences between control and processed samples immediately after processing. Obtained results were used along with appropriate tools relevant to cold chain management to demonstrate that HP treated products are less perishable compared to control ones, allowing for short exposure to temperature deviations during transportation and storage. This has a positive impact on the reduction of the frequency of spoiled products before consumption, acting as a useful tool for the meat product’s loss and waste reduction.
Generalized Structures for Switched-Capacitor Multilevel Inverter Topology for Energy Storage System Application
Authors: Anas Mu , Sarwar Adil , Ahmad Anzar , Alam Afroz , Ahmad Shafiq , Sharaf Mohamed , Zaindin Mazen , Firdausi Muhammad
Published: February 2021

The apparent advantages of Multilevel Inverter (MLI) topologies in handling medium and high power with less loss in switching and lower harmonic distortion in an output voltage waveform makes it better than the conventional inverter. However, the MLI topologies utilize a large number of DC power supplies and power semiconductor devices. They also have a higher value of total standing voltage (TSV). Moreover, capacitor voltage balancing problems, self-voltage boosting inability, and complex control techniques require a relook and improvement in their structure. More recently, Switched-Capacitor Multilevel Inverter (SCMLI) topologies have been proposed to overcome the shortcomings of MLIs. In this paper, a generalized structure for a single-phase switched capacitor multilevel inverter (SCMLI) with self-voltage boosting and self-voltage balancing capability is proposed. A detailed analysis of a general structure of SCMLI is presented. The comparative analysis of the structures is carried out with recently reported topologies to demonstrate superiority. An optimized low-frequency modulation controls the output voltage waveform. The simulation and experimental results are included in the paper for single-unit symmetric (9-level voltage) and asymmetric (17-level voltage) configurations.
Comparative Studies on the Fatty Acid Profile and Volatile Compounds of Fallow Deer and Beef Fermented Sausages without Nitrite Produced with the Addition of Acid Whey
Authors: Karwowska Małgorzata , Kononiuk Anna D. , Borrajo Paula , Lorenzo José M.
Published: February 2021

This study aims to improve knowledge on fermented beef and fallow deer sausages and the effect of nitrite elimination and the addition of freeze dried acid whey on the fatty acid profile and volatile compounds. Three different formulations within each of the two product groups, made of beef and fallow deer meat, respectively, were prepared: control sample with sodium nitrite, sample without nitrite, and sample without nitrite and with the addition of freeze-dried acid whey powder (0.7%). After production, the sausages were subjected to analysis including proximate chemical composition, pH and water activity, Thiobarbituric Acid Reactive Substance (TBARS), fatty acid profile, and volatile compound determination. The fermented sausages were characterized by an average pH and water activity in the range of 5.23–5.79 and 0.910–0.918, respectively. Fallow deer sausages were characterized by a higher content of saturated and polyunsaturated fatty acids in comparison to beef sausages. The elimination of nitrite did not significantly affect the amount of volatile compounds in fermented sausages. However, the effect of the freeze-dried acid whey powder addition on the amount of some volatile compounds in uncured sausages was observed, in particular, that derived from bacterial metabolism.
Atmospheric Deposition and Element Accumulation in Moss Sampled across Germany 1990–2015: Trends and Relevance for Ecological Integrity and Human Health
Authors: Schlutow Angela , Schröder Winfried , Nickel Stefan
Published: February 2021

Deposition of N and heavy metals can impact ecological and human health. This state-of-the-art review addresses spatial and temporal trends of atmospheric deposition as monitored by element accumulation in moss and compares heavy metals Critical Loads for protecting human health and ecosystem’s integrity with modelled deposition. The element accumulation due to deposition was measured at up to 1026 sites collected across Germany 1990–2015. The deposition data were derived from chemical transport modelling and evaluated with regard to Critical Loads published in relevant legal regulations. The moss data indicate declining nitrogen and HM deposition. Ecosystem and human health Critical Loads for As, Ni, Zn, and Cr were not exceeded in Germany 2009–2011. Respective Critical Loads were exceeded by Hg and Pb inputs, especially in the low rainfall regions with forest coverage. The Critical Load for Cu was exceeded by atmospheric deposition in 2010 in two regions. Human health Critical Loads for Cd were not exceeded by atmospheric deposition in 2010. However, the maximum deposition in 2010 exceeded the lowest human health Critical Load. This impact assessment was based only on deposition but not on inputs from other sources such as fertilizers. Therefore, the assessment should be expanded with regard to other HM sources and specified for different ecosystem types.
Temperature Projections over the Indus River Basin of Pakistan Using Statistical Downscaling
Authors: Pomee Muhammad Saleem , Hertig Elke
Published: February 2021

We assessed maximum (Tmax) and minimum (Tmin) temperatures over Pakistan’s Indus basin during the 21st century using statistical downscaling. A particular focus was given to spatiotemporal heterogeneity, reference and General Circulation Model (GCM) uncertainties, and statistical skills of regression models using an observational profile that could significantly be improved by recent high-altitude observatories. First, we characterized the basin into homogeneous climate regions using K-means clustering. Predictors from ERA-Interim reanalysis were then used to model observed temperatures skillfully and quantify reference and GCM uncertainties. Thermodynamical (dynamical) variables mainly governed reference (GCM) uncertainties. The GCM predictors under RCP4.5 and RCP8.5 scenarios were used as “new” predictors in statistical models to project ensemble temperature changes. Our analysis projected non-uniform warming but could not validate elevation-dependent warming (EDW) at the basin scale. We obtained more significant warming during the westerly-dominated seasons, with maximum heating during the winter season through Tmin changes. The most striking feature is a low-warming monsoon (with the possibility of no change to slight cooling) over the Upper Indus Basin (UIB). Therefore, the likelihood of continuing the anomalous UIB behavior during the primary melt season may not entirely be ruled out at the end of the 21st century under RCP8.5.
The Italian National Air Pollution Control Programme: Air Quality, Health Impact and Cost Assessment
Authors: Piersanti Antonio , D’Elia Ilaria , Gualtieri Maurizio , Briganti Gino , Cappelletti Andrea , Zanini Gabriele , Ciancarella Luisella
Published: February 2021

Air pollution is the primary environmental cause of death globally. To improve air quality and reduce health impacts, the National Emission Ceilings Directive requires Member States of the European Union to provide National Air Pollution Control Programmes, including emission reduction measures aimed to achieve binding commitments for the years 2020 and 2030. Integrated assessment models are pivotal to assess the reduction of pollutants concentrations determined by measures implemented or foreseen for emission reduction. Here we discuss scenarios elaborated for year 2030 in the Italian National Air Pollution Control Programme, considering 2010 as reference year. The two scenarios, “With Measures” and “With Additional Measures”, show a significant reduction of the pollutants concentration, namely PM2.5, NO2 and O3. The scenarios are here also used to provide an integrated approach for calculating the effect of the program on health impacts (mortality) and related costs. Avoidable attributable cases and associated costs are here reported at both the national and regional level and provide a significant framework to assess air-pollution reduction measures with an integrated approach. The procedure proposed may be therefore further developed and applied to assess the overall positive benefits (environmental, health and economic) determined by air-pollution control plans or other integrated policies targeting air quality, energy and climate goals.
Benign Positional Paroxysmal Vertigo in Children
Authors: Balzanelli Cristiano , Spataro Daniele , Redaelli de Zinis Luca Oscar
Published: February 2021

The aim of this study was to assess the prevalence and analyze clinical parameters of benign positional paroxysmal vertigo (BPPV) in a pediatric age. A cohort of 423 children under the age of 15 (median age 11. interquartile range 9–13) was submitted to vestibular assessment for balance disorders. Dix-Hallpike and Roll-Supine tests were performed to look for positioning nystagmus using video-infrared goggles. BPPV was found in 43 of 423 children evaluated for balance disorders (10.2%). There were 28 females (65.1%) and 15 (34.9%) males. The posterior canal was involved in 79% of cases and the horizontal canal in 21% of cases. No apogeotropic bilateral or anterior canal form were seen. Thus, BPPV is not an infrequent type of vertigo in children and must be evaluated as soon as possible in order to plan the most appropriate maneuver and restore daily activities as soon as possible, avoiding anxiety and fear.
Robotic Radiosurgery for Persistent Postoperative Acromegaly in Patients with Cavernous Sinus-Invading Pituitary Adenomas—A Multicenter Experience
Authors: Ehret Felix , Kufeld Markus , Fürweger Christoph , Haidenberger Alfred , Windisch Paul , Fichte Susanne , Lehrke Ralph , Senger Carolin , Kaul David , Rueß Daniel , Ruge Maximilian , Schichor Christian , Tonn Jörg-Christian , Stalla Günter , Muacevic Alexander
Published: February 2021

Background: The rates of incomplete surgical resection for pituitary macroadenomas with cavernous sinus invasion are high. In growth hormone-producing adenomas, there is a considerable risk for persistent acromegaly. Thus, effective treatment options are needed to limit patient morbidity and mortality. This multicenter study assesses the efficacy and safety of robotic radiosurgery (RRS) for patients with cavernous sinus-invading adenomas with persistent acromegaly. Methods: Patients who underwent RRS with CyberKnife for postoperative acromegaly were eligible. Results: Fifty patients were included. At a median follow-up of 57 months, the local control was 100%. The pretreatment insulin-like growth factor 1 (IGF-1) levels and indexes were 381 ng/mL and 1.49, respectively. The median dose and prescription isodose were 18 Gy and 70%, respectively. Six months after RRS, and at the last follow-up, the IGF-1 levels and indexes were 277 ng/mL and 1.14, as well as 196 ng/mL and 0.83, respectively (p = 0.0001 and p = 0.0002). The IGF-1 index was a predictor for biochemical remission (p = 0.04). Nine patients achieved biochemical remission and 24 patients showed biochemical disease control. Three patients developed a new hypopituitarism. Conclusions: RRS is an effective treatment for this challenging patient population. IGF-1 levels are decreasing after treatment and most patients experience biochemical disease control or remission.
Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer
Authors: Sekine Hiroki , Motohashi Hozumi
Published: February 2021

Cancer cells exhibit unique metabolic features and take advantage of them to enhance their survival and proliferation. While the activation of NRF2 (nuclear factor erythroid 2-like 2; NFE2L2), a CNC (cap‘n’collar) family transcription factor, is effective for the prevention and alleviation of various diseases, NRF2 contributes to cancer malignancy by promoting aggressive tumorigenesis and conferring therapeutic resistance. NRF2-mediated metabolic reprogramming and increased antioxidant capacity underlie the malignant behaviors of NRF2-activated cancer cells. Another member of the CNC family, NRF1, plays a key role in the therapeutic resistance of cancers. Since NRF1 maintains proteasome activity by inducing proteasome subunit genes in response to proteasome inhibitors, NRF1 protects cancer cells from proteotoxicity induced by anticancer proteasome inhibitors. An important metabolite that activates NRF1 is UDP-GlcNAc (uridine diphosphate N-acetylglucosamine), which is abundantly generated in many cancer cells from glucose and glutamine via the hexosamine pathway. Thus, the metabolic signatures of cancer cells are closely related to the oncogenic and tumor-promoting functions of CNC family members. In this review, we provide a brief overview of NRF2-mediated cancer malignancy and elaborate on NRF1-mediated drug resistance affected by an oncometabolite UDP-GlcNAc.
Regulatory Interplay between miR-181a-5p and Estrogen Receptor Signaling Cascade in Breast Cancer
Authors: Benedetti Rosaria , Papulino Chiara , Sgueglia Giulia , Chianese Ugo , De Marchi Tommaso , Iovino Francesco , Rotili Dante , Mai Antonello , Niméus Emma , Dell’ Aversana Carmela , Altucci Lucia
Published: February 2021

The efficacy and side effects of endocrine therapy in breast cancer (BC) depend largely on estrogen receptor alpha (ERα) expression, the specific drug administered, and treatment scheduling. Although the benefits of endocrine therapy outweigh any adverse effects in the initial stages of BC, later- or advanced-stage tumors acquire resistance to treatments. The mechanisms underlying tumor resistance to therapy are still not well understood, posing a major challenge for BC patient care. Epigenetic regulation and miRNA expression may be involved in the switch from a treatment-sensitive to a treatment-resistant state and could provide a valid therapeutic strategy for ERα negative BC. Here, a hybrid lysine-specific histone demethylase inhibitor, MC3324, displaying selective estrogen receptor down-regulator-like activities in BC, was used to highlight the interplay between epigenetic and ERα signaling. MC3324 anticancer action is mediated by microRNA (miRNA) expression regulation, indicating an innovative function for this molecule. Integrated analysis suggests a crosstalk between estrogen signaling, ERα interactors, miRNAs, and their putative targets. Specifically, miR-181a-5p expression is regulated by MC3324 and has an impact on cellular levels of ERα. A comparison of breast tumor versus healthy mammary tissues confirmed the important role of miR-181a-5p in ERα regulation and points to its putative predictive function in BC therapy.
Bone Targeting Agents in Patients with Metastatic Prostate Cancer: State of the Art
Authors: Mollica Veronica , Rizzo Alessandro , Rosellini Matteo , Marchetti Andrea , Ricci Angela Dalia , Cimadamore Alessia , Scarpelli Marina , Bonucci Chiara , Andrini Elisa , Errani Costantino , Santoni Matteo , Montironi Rodolfo , Massari Francesco
Published: February 2021

Bone health represents a major issue in castration-resistant prostate cancer (CRPC) patients with bone metastases; in fact, the frequently prolonged use of hormonal agents causes important modifications in physiological bone turnover and most of these men will develop skeletal-related events (SREs), including spinal cord compression, pathologic fractures and need for surgery or radiation to bone, which are estimated to occur in almost half of this patient population. In the last decade, several novel therapeutic options have entered into clinical practice of bone metastatic CRPC, with recent approval of enzalutamide and abiraterone acetate, cabazitaxel chemotherapy and radium-223, on the basis of survival benefit suggested by landmark Phase III trials assessing these agents in this setting. Conversely, although bone-targeted agents (BTAs)—such as the bisphosphonate zoledronic acid and the receptor activator of nuclear factor kappa-B (RANK) ligand inhibitor denosumab—are approved for the prevention of SREs, these compounds have not shown benefit in terms of overall survival. However, emerging evidence has suggested that the combination of BTAs and abiraterone acetate, enzalutamide and the radiopharmaceutical radium-223 could result in improved clinical outcomes and prolonged survival in bone metastatic CRPC. In this review, we will provide an overview on bone tropism of prostate cancer and on the role of BTAs in metastatic hormone-sensitive and castration-resistant prostate cancer.
Versatile Coordination Polymer Catalyst for Acid Reactions Involving Biobased Heterocyclic Chemicals
Authors: Antunes Margarida M. , Mendes Ricardo F. , Paz Filipe A. Almeida , Valente Anabela A.
Published: February 2021

The chemical valorization/repurposing of biomass-derived chemicals contributes to a biobased economy. Furfural (Fur) is a recognized platform chemical produced from renewable lignocellulosic biomass, and furfuryl alcohol (FA) is its most important application. The aromatic aldehydes Fur and benzaldehyde (Bza) are commonly found in the slate of compounds produced via biomass pyrolysis. On the other hand, glycerol (Gly) is a by-product of the industrial production of biodiesel, derived from fatty acid components of biomass. This work focuses on acid catalyzed routes of Fur, Bza, Gly and FA, using a versatile crystalline lamellar coordination polymer catalyst, namely [Gd(H4nmp)(H2O)2]Cl·2H2O (1) [H6nmp=nitrilotris(methylenephosphonic acid)] synthesized via an ecofriendly, relatively fast, mild microwave-assisted approach (in water, 70 °C/40 min). This is the first among crystalline coordination polymers or metal-organic framework type materials studied for the Fur/Gly and Bza/Gly reactions, giving heterobicyclic products of the type dioxolane and dioxane, and was also effective for the FA/ethanol reaction. 1 was stable and promoted the target catalytic reactions, selectively leading to heterobicyclic dioxane and dioxolane type products in the Fur/Gly and Bza/Gly reactions (up to 91% and 95% total yields respectively, at 90 °C/4 h), and, on the other hand, 2-(ethoxymethyl)furan and ethyl levulinate from heterocyclic FA.