bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinant Factors of Type 2 Diabetes Mellitus Among Older Adults in Kelating Village
Authors: Pake Indry Agatha Rihi , Putra I Made Gede Dwipayana , Adrya Jessica , Jayaningrat Dewa Ayu Tri , Wirawan I Made Suma
Published: February 2025

Type 2 diabetes mellitus (DM) increased in the elderly population due to metabolic changes and decreased function of pancreatic β cells. This study aims to determine the prevalence of type 2 diabetes mellitus in the elderly and examine the risk factors—such as age, gender, blood pressure, and uric acid levels—that influence the incidence of type 2 DM. This cross-sectional study involved 31 elderly people (≥60 years) in Segara Santhi, Kelating Village, Tabanan, who were selected using purposive random sampling. Fasting blood glucose and uric acid levels were checked using Accu-Chek after fasting for at least 8 hours. Data analysis used the Fisher's Exact Test with a significance of p<0.05. The results show prevalence of type 2 DM was 64.5% (20 of 31 respondents). Age and type 2 DM had no significant association (p= 0.262). However, there was a significant association between type 2 DM and gender (p = 0.012) and uric acid levels (p = 0.029), but not with blood pressure (p = 1,000). The prevalence of type 2 DM in the elderly in Segara Santhi is quite high, but age is not the main factor. Other factors such as diet, physical activity, and genetic predisposition may play a greater role. Further studies with larger sample sizes and multivariate analysis are needed to understand the risk factors for type 2 DM in the elderly more specifically.
Manejo de Transtornos Psiquiátricos em Gestantes na Sala de Emergência
Authors: Meira Carolina Silva Ruelis de , Zanon Iasmyn Fantin , Florenço Athus Paulo , Ferreira Letícia Gabriela Martins , Sousa Thaís Bruna Melo , Skiba Thairan Viana , Dorneles Eduarda Cristina Borges , Vasconcelos Flavio Ercio Coelho de , Paula Graziela Teixeira de , Martins João Paulo Passos , Júnior Luiz Cláudio Esteves Ramos , Bezerra Rosicler da Silva Cruz , Cunha Rodolfo Nunes Mendes da , Castro Larissa Braga , Melo Ana Carolina de
Published: February 2025

A gestação é um período marcado por profundas mudanças biológicas, psicológicas e sociais, que podem exacerbar ou desencadear transtornos psiquiátricos em mulheres predispostas. As emergências psiquiátricas, como transtornos de humor, ansiedade, psicose e uso de substâncias, requerem intervenções rápidas devido ao seu impacto na saúde materna e nos desfechos obstétricos. O objetivo dessa pesquisa consistiu em explorar as principais condições psiquiátricas emergenciais, suas implicações para a saúde materno-fetal e as abordagens terapêuticas mais adequadas para cada casos e para sua confecção, foram realizadas buscas em bases de dados renomadas, selecionando-se 16 artigos referenciais que se enquadraram nos critérios pré-estabelecidos. O manejo dessas condições psiquiátricas exige uma abordagem multidisciplinar e individualizada, considerando os efeitos dos tratamentos no feto e equilibrando os riscos teratogênicos com os benefícios para a saúde mental da gestante
DESAFIOS NOS CUIDADOS DE ENFERMAGEM A POPULAÇÃO TRANSSEXUAL NA ATENÇÃO BÁSICA: REVISÃO INTEGRATIVA
Authors: Lima Pedro , Nascimento Ana , Jesus Jamilly , Sá Leticia , Silva Marcelha , Silva Aylane , Silva Janaína , Alencar Lindalva , Santos Mikellane , Conceição Cleirton , Sousa Rikelme , Aguiar Jéssica
Published: February 2025

O objetivo deste artigo é discutir as principais perspectivas acerca dos cuidados de enfermagemdestinados à população transexual nos serviços de saúde. Trata-se de uma revisão integrativada literatura realizada na base de dados BDENF, utilizando os descritores “Transexuais”,“Assistência à Saúde” e “Cuidados de Enfermagem”, associados ao operador booleano AND.Foram incluídos artigos publicados no período de 2018 a 2024, nos idiomas português, inglês eespanhol, disponíveis na íntegra. Após a aplicação dos critérios de exclusão, restaram 10artigos, os quais foram agrupados em três categorias. A primeira categoria aborda a baixaassiduidade da população transexual aos serviços de saúde e a pouca adesão às açõesoferecidas. A segunda discute a importância da visibilidade da comunidade transexual dentrodos setores hospitalares. A última trata do preconceito enraizado nos profissionais de saúde emrelação a essa população, o que, infelizmente, prejudica a garantia de seus direitos à saúde. Apartir da análise das literaturas selecionadas, foi possível inferir que a população transexualenfrenta diversos problemas em relação ao acesso à atenção básica de saúde. No presentetrabalho, serão discutidos aspectos que vão desde sua invisibilidade até o atendimento nossetores hospitalares.
COMPREENDENDO OS EFEITOS DO ENVELHECIMENTO NA FUNÇÃO COGNITIVA: EXPLORANDO ESTRATÉGIAS DE INTERVENÇÃO CONTRA O ALZHEIMER
Authors: Gonçalves de Moraes Bolzan Lara , Sales Zampirolli Anita , Zago Monteiro Barbosa Gabriel , Marconcini Rohr Jainy , Victoria Lino Ramos Ellen , Salarolli Lorencini , Victor , Sales Zampirolli Alice , Da Silva Gava Maria Eduarda , Marchiori Simões Ana Clara , Zanette Macedo Maria Eduarda
Published: February 2025

INTRODUÇÃO: A Doença de Alzheimer (DA) é uma condição neurodegenerativa caracterizada pelo comprometimento cognitivo progressivo. Embora já existam meios de intervenção eficazes, atualmente não há um tratamento definitivo que possa curar ou reverter a deterioração causada pela DA no funcionamento cognitivo dos idosos, população mais acometida pela doença. Ainda que existam meios farmacológicos, há comprovação que meios não farmacológicos são mais acessíveis e eficazes para o regresso da neurodegeneração, como a prática de atividade física, a melhoria do sono e a implementação de uma dieta saudável. A necessidade de explorar e abordar os fatores estruturais presentes na implementação de novas estratégias de intervenção contra a DA é fulcral para o tratamento precoce da doença. OBJETIVOS: Revisar e sintetizar as evidências atuais sobre os efeitos do envelhecimento na função cognitiva, com foco na deterioração cognitiva relacionada ao Alzheimer. E analisar as intervenções voltadas à promoção da saúde cognitiva na terceira idade. METODOLOGIA: O presente estudo consiste em uma Revisão Bibliográfica realizada no período de junho a julho de 2024. Utilizando a base de dados PubMed e Scientific Electronic Library Online (SciELO).  Os critérios de inclusão foram: artigos nos idiomas Português, Inglês, espanhol e Francês; publicados no período de 2019 a 2024. RESULTADOS: Os resultados apontam que, por se tratar de uma condição multifatorial, as práticas interventivas  relacionadas à Doença de Alzheimer devem estar concernentes aos fatores que implicam no preservamento ou na melhora da função cognitiva durante o envelhecimento. A pesquisa destacou que o tratamento farmacológico, embora seja menos recorrente, consiste na prescrição de anticolinesterásicos e de memantina. Em contrapartida, a intervenção não farmacológica, que tem se mostrado mais importante na atualidade, diz respeito ao retardamento da disfunção cognitiva com o decorrer do tempo - visto que a prática de exercícios aeróbicos aumentam o nível do fator neurotrófico ligado à cognição, que o controle do ciclo circadiano diminui distúrbios do sono que podem levar ao acúmulo patológico de proteínas que causam a neurodegeneração, e que uma dieta rica em antioxidantes e vitaminas ajuda no funcionamento neuronal. CONCLUSÃO: O presente artigo enfatiza a importância de adotar abordagens que promovam um estilo de vida saudável, sendo esse o meio de intervenção mais importante, que trata tanto aspectos de envelhecimento quanto fatores específicos da Doença de Alzheimer, como o declínio cognitivo.
HRIS and Automation
Authors:   Consultant of Human Resources Management-US, Alzabin Mohammad Said Suliman
Published: February 2025

In the modern era, organizations are increasingly relying on advanced technological solutions to enhance their hu-man resource management (HRM) practices. Human Resource Information Systems (HRIS) and automation have revolutionized the HR landscape, driving efficiency, reducing costs, and enabling strategic decision-making. This document explores the key applications, benefits, and case studies of HRIS and automation while evaluating their impact on workforce management and organizational growth.
Meningkatkan User Experience Aplikasi GIS Melalui Penerapan Quality Assurance
Authors: Sondara Wicaksana Megah Juliardi , Nurkamal Fauzan Mohammad
Published: February 2025

Aplikasi web bangunan bersejarah di Singapura menghadapi tantangan dalam kompatibilitas dan performa lintas platform. Untuk mengatasi hal ini, penelitian ini menggunakan pendekatan mass testing dan Lighthouse guna mengevaluasi performa aplikasi di berbagai sistem operasi dan browser. Mass testing dilakukan untuk mengidentifikasi kendala kompatibilitas dan stabilitas aplikasi saat diakses oleh banyak pengguna secara bersamaan. Lighthouse digunakan untuk menganalisis aspek performa, aksesibilitas, praktik terbaik, dan SEO. Hasil pengujian menunjukkan bahwa 60% skenario mengalami kendala, terutama pada Chrome (Android) dan Edge (Windows), sementara Safari di iOS menunjukkan kompatibilitas terbaik. Skor performa Lighthouse lebih rendah pada Chrome dan Edge dibandingkan Firefox. Rekomendasi perbaikan meliputi optimasi kode, penyesuaian rasio aspek gambar, serta pengujian lintas platform guna meningkatkan kualitas dan pengalaman pengguna aplikasi
ANALISIS REGRESI LINEAR BERGANDA UNTUK MENGETAHUI FAKTOR YANG MEMPENGARUI KEJADIAN STUNTING DI KOTA LANGSA
Authors: KURNIAWAN AGUS , Fairus Fairus
Published: February 2025

Stunting adalah istilah yang merujuk pada keterbelakangan pertumbuhan anak dalam hal panjang atau tinggi badan menurut usia, dari masa kandungan hingga dua tahun pertama setelah kelahiran, yang tidak mencapai potensi genetik yang seharusnya. Di Kota Langsa, upaya untuk menurunkan angka kejadian stunting telah memberikan hasil, dengan penurunan mencapai 22,1% pada tahun 2022. Namun, pemerintah kota masih berkomitmen untuk menekan angka stunting lebih lanjut. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang mempengaruhi terjadinya stunting di Kota Langsa dengan menggunakan metode analisis Regresi Linear Berganda. Diharapkan hasil penelitian ini dapat memberikan wawasan yang berguna bagi pemerintah kota dalam merancang kebijakan yang lebih efektif untuk menurunkan angka kejadian stunting. Metode Regresi Linear Berganda digunakan untuk mengkaji hubungan linier antara beberapa variabel yang saling terkait. Hasil penelitian menunjukkan bahwa semua variabel independen memiliki pengaruh terhadap kejadian stunting di tingkat Gampong/Desa di Kota Langsa. Di antara variabel tersebut, tiga variabel yang paling berpengaruh adalah Inisiasi Menyusui Dini (IMD), pemberian ASI Ekslusif, dan kegiatan penimbangan balita.
THE INFLUENCE OF SOCIAL MEDIA ON RECRUITMENT EFFECTIVENESS AND POST-HIRE EMPLOYEE ENGAGEMENT: A STUDY OF PRE- AND POST-HIRE OUTCOMES
Authors: Ch. Manasa  , Y. Suryanarayana Murthy
Published: February 2025

The purpose of this study is to examine the influence of social media on recruitment effectiveness and post-hire employee engagement, focusing on the credibility and satisfaction associated with social media platforms. The research explores both pre-hire and post-hire outcomes to understand the full recruitment lifecycle. A quantitative research design was employed, utilizing a survey method to collect data from human resource professionals and employees across various organizations. The analysis will be conducted using statistical techniques, such as regression analysis and structural equation modelling, to assess the relationships between social media use, recruitment outcomes, and employee engagement. The findings reveal that social media enhances recruitment efficiency by improving candidate credibility and satisfaction during the pre-hire phase, leading to higher engagement in the post-hire phase. However, reliance on social media alone has limitations in assessing long-term employee retention. This study provides practical implications for HR managers to integrate social media as a key recruitment tool while acknowledging its limitations. It also contributes to the literature on employee engagement, offering a comprehensive view of recruitment outcomes. The originality of the study lies in its dual focus on both recruitment and post-hire outcomes through social media use, filling a gap in existing research.
KEYWORDS: Social Media, Recruitment, Employee Engagement, Pre-Hire Outcomes, Post-Hire Outcomes, Credibility, Satisfaction.
OPTIMIZATION OF THE PARAMETERS OF REPAIR AND CONSTRUCTION WORKS DURING THE RESTORATION OF A REINFORCED CONCRETE PIPELINE
Authors: Shumakov I. , Buhaievski V.
Published: February 2025

Abstract. Reinforced concrete bridge structures have been widely erected in various countries since the middle of the 20th century. For such structures, problems of reduced durability due to damage from various influences are often found. Degradation mechanisms of structures significantly reduce the duration of safe operation. Rehabilitation and restoration of reinforced concrete of bridges and overpasses requires rational solutions for predicting the long-term strength of structures. Economic indicators of restoration are consistent with the duration of works, which is important for large cities. The presented studies reflect the optimization of structural and technological solutions during the capital repair of the overpass in Kyiv. The surveys carried out at the stage of project preparation did not give a complete reflection of the technical condition of the building for the preparation of final repair decisions, full information was obtained only after partial dismantling of the damaged structures. The support posts had corrosion of concrete and reinforcement, vertical stress cracks, delamination of concrete layers, leaching and locking of concrete. It is proposed to preserve part of the damaged structures of reinforced concrete supports with their strengthening. Removal of damaged concrete and exposure of working fittings, arrangement of additional reinforcing frame, external concreting of racks with a self-compacting mixture in fixed formwork made of metal pipes are provided for. The technology of restoration and reinforcement of the rack made it possible to preserve the existing reinforcement of the rack and its anchoring in the body of the bored pile. The removal of part of the damaged concrete was carried out in accordance with the sequence and volume of dismantling works. The reduction in the duration of restoration works, which is crucial in the conditions of intensive car traffic in the city, took place by 17%. The parameters of the bearing capacity and the design service life of the restored rack have been brought to the level of the parameters of the new design.
Objective Structured Clinical Examinations practices across Canadian medical schools: a national overview
Authors: Gilchrist Chris , Bismilla Zia
Published: February 2025

Introduction: Objective Structured Clinical Examinations (OSCEs) are crucial in assessing clinical competencies, but their implementation varies widely across medical schools. This work examines OSCE practices across Canadian medical schools, focusing on frequency, type, and timing.
Methods: A survey was conducted among all 17 Canadian medical schools through the AFMC Clinical Skills Working Group. Data were collected during the 2023-2024 academic year. Details on OSCEs implementation during pre-clerkship and clerkship phases, categorized as formative or summative, and on the timing of final OSCEs was collected. Descriptive statistics were used to analyze the data.
Results: The median number of OSCEs per school was four, with one-third formative and two-thirds summative. Pre-clerkship assessments were split between formative and summative OSCEs, while 78% of clerkship OSCEs were summative. Timing of a program’s final OSCE varied: 35% occurred before the last year, while 65% took place in the final year, predominantly in the second half. All final OSCEs were summative.
Discussion and Conclusion: Variability in OSCE implementation likely reflects differing curricular approaches and institutional constraints. This work demonstrated a more balanced proportion of formative and summative assessments during pre-clerkship, indicating a desire to provide students with opportunities learn from feedback during their early training years. During clerkship, the focus shifted towards summative assessments. The later emphasis on summative OSCEs may highlight a focus on certifying competence at the cost of reduced opportunities for formative feedback. Medical schools may use these findings as guidance when building their programs of assessment.
STUDY LITERATUR: STRATEGI MANAJEMEN PAUD UNTUK MENINGKATKAN KUALITAS PENDIDIKAN DI INDONESIA
Authors: Setyowati Rina Insani
Published: February 2025

Analisis strategi manajemen PAUD untuk meningkatkan kualitas pendidikan di Indonesia tantangan utama yang masih dihadapi dalam implementasi strategi manajemen PAUD adalah kurangnya koordinasi antara lembaga pendidikan dan pemerintah dalam menetapkan standar mutu yang jelas. Penelitian ini membahas tentang berbagai alternatif Upaya peningkatan strategi manajemen PAUD untuk meningkatkan kualitas pendidikan di Indonesia, penelitian ini menggunakan Penelitian ini menggunakan pendekatan kualitatif dengan metode studi literatur. Studi literatur digunakan untuk mengumpulkan dan menganalisis berbagai penelitian terdahulu terkait strategi manajemen PAUD dalam meningkatkan kualitas pendidikan. Menurut Creswell (2014), pendekatan kualitatif memungkinkan peneliti untuk memahami secara mendalam konsep, teori, serta praktik terbaik yang telah diterapkan dalam pengelolaan PAUD. Adapun hasil study literatur Bagi Kebijakan: Pemerintah dapat mempertimbangkan peningkatan anggaran untuk pelatihan guru dan penyediaan sarana belajar. Bagi Praktik Pendidikan: Lembaga PAUD dapat menerapkan strategi holistik dengan melibatkan orang tua dan memanfaatkan teknologi.
SMART HOME AUTOMATION USING ESP8266 WIFI MODULE
Authors: Vishal Harashetty , C H V Ganesh  , M Krishna  , D Divya  , S Rajesh
Published: February 2025

This project outlines Smart home automation has emerged as a transformative technology, enhancing convenience, security, and energy efficiency in residential environments. This paper explores the implementation of a smart home system using the ESP8266 Wi-Fi module, a low-cost and highly integrated device that facilitates seamless wireless communication. By leveraging the ESP8266's capabilities, we develop a network of interconnected devices like dth sensor and LDR sensor enabling remote control and automation of household appliances through a user-friendly mobile application
SMILE CRAFT LABORATORY A DENTAL LAB APPLICATION DEVELOPED USING MERN STACK
Authors: Lohitha Saripalli , Reshma  , C. Venugopal  , Prasad V.Shiva , S.Veeraiah
Published: February 2025

The focus of this third application, which is built on MERN stack technologies, is to change the manner, users select and create dental prosthetics. The concept is simple: the user is presented with a number of options which include different kinds and materials of the teeth. The application is designed to be very easy-to-use and therefore walks users through a sequence of actions aimed at assisting them provide information on the ideal dental solution that meets their needs. Furthermore, detailed images and thorough explanations of the possibilities offered are presented so that the user will be more satisfied with the end results.It consists of three, admin, doctor and patient each with its own respective accounts. The doctor shall be able to view the appoinments booked with him along with the patients who have booked the appoinments, edit the patients image, and contact the administrator through a googleform. The patient has the capability to surf through the website, view the doctors practicing there and book consultation based on their area. All the data will be maintained by the admin who can add more physicians, view the status of the physicians whether they are active or not, view the messages that the physician has and adds new physician The application’s backend does use MongoDB, Express, React, NodeJS which makes the performance sure enough strong with much more efficiency and security that covers all the requirements of modern day architecture of dentistry.
Concepções sobre letramento em matemática e em educação financeira de futuros professores dos cursos de Matemática e Pedagogia
Authors: Moraes Francisco Ronald Feitosa
Published: February 2025

This text aims to present the conceptions of future teachers from Mathematics and Pedagogy programs at the Regional University of Cariri (URCA) regarding Mathematical and Financial Literacy, concepts underlying ideological literacy. To this end, we developed an online questionnaire using the Google Forms tool, consisting of 30 open questions — open-ended, closed-ended, and multiple-choice — about Financial Mathematics, Financial Education and Mathematical and Financial Literacy. The questionnaire collected responses from 78 students, 43 from the Mathematics program and 35 from the Pedagogy program, which were categorized and analyzed based on the principles of content analysis. We found that the conceptions of future teachers are, for the most part, formed by characteristics of the concept of autonomous literacy, which emphasizes the acquisition of reading and writing skills detached from the contextual reality of individuals engaged in learning Mathematics and Financial Mathematics. However, some conceptions exhibited characteristics of ideological literacy, demonstrating concern for critically and reflectively contextualizing concepts to promote social justice, both in teaching practices and in society as a whole.
Health Care Orders in Legislation, Doctrine and Notarial Practice as a Means of Protecting the Autonomy of Will of a Person
Authors:   Chelyabinsk State University, Ostanina Elena A.
Published: February 2025

The article analyses the institute of sickness orders. It is concluded that domestic law does not know such an institute; the tasks that in German law are solved by sickness orders, in our country are partly solved by the contract of trust management of property, and partly remain unresolved. The author shows that sickness orders could protect the non-property and property interests of a citizen. The article defines a model of possible regulation of orders in case of illness, proposes their notarial form and register, concludes that the scope of powers of the representative will have significant similarity with the powers of the legal representative.
Credibility and Truth in Market Value Estimation
Authors:   Saint Petersburg State University, Savinykh Vladislav A.
Published: February 2025

The article deals with the position of the Supreme Court of the Russian Federation, according to which the results of auctions more reliably reflect the market value than expert estimates. Starting from the fact that the reliability of expert assessment of market value is detached from comparison with objective reality, the author criticises the approach of the Supreme Court, proving that expert assessment is the only admissible evidence of market value, even in conditions of interval nature of assessments.
The The Influence of Perception of Convenience, Benefits, and Risks on the Decision to Use DANA E-Wallet Among Generation Z in East Jakarta City
Authors: Nurfadillah Chika , Nikensari Sri Indah , Iranto Dicky
Published: February 2025

Purpose of the study: The main objective of this study is to examine the influence of perceived ease of use, perceived benefits, and perceived risks on the decision to use the DANA E-Wallet among Generation Z in East Jakarta.
Methodology: The methodology used is a quantitative approach. This study was conducted only in East Jakarta with 102 Generation Z respondents residing in East Jakarta. The data analysis techniques employed in this study include instrument testing, prerequisite analysis testing, hypothesis testing using partial tests (t-test), and multiple linear regression analysis.
Main Findings: The results of the testing conducted in this study show that perceived ease of use, perceived benefits, and perceived risks have a positive and significant impact on the decision to use the DANA e-wallet among Generation Z in East Jakarta.
Novelty/Originality of this study: The COVID-19 pandemic has accelerated the adoption of technology, including the use of e-wallets. Studies conducted after the pandemic may show changes in consumer behavior, particularly in the digital financial transaction habits of Generation Z. Research focusing on the behavior of Generation Z in major cities in Indonesia, such as East Jakarta, could provide novelty, considering the unique cultural and economic context of the region.
Organizational Culture Transformation in the New Public Management Era: Case Study of Implementation in Indonesian Local Government
Authors: Ihyauddin Ihyauddin , Adi Bambang Tri Sasongko , Sukmana Oman
Published: February 2025

Purpose of the study: The main objective of this study is to understand and evaluate the results of the implementation of New Public Management on the transformation of organizational culture in local government.
Methodology: This study uses a qualitative approach. The research design used is a case study design. The population in this study includes local government employees involved in the implementation of NPM and organizational culture transformation. Sample selection was carried out through purposive sampling techniques.
Main Findings: The findings show a cultural shift from procedure-oriented to outcome-oriented, supported by decentralization of decision-making and increased employee participation. However, resistance to change and resource constraints remain significant challenges. The study highlights leadership commitment, effective communication, and locally tailored policies as critical factors in successful transformation.
Novelty/Originality of this study: This research contributes to the public management literature and offers practical insights for improving the quality of public services.
The Nature and Trends of Student Activism in Contemporary African Higher Education
Authors: Mukasa Bart
Published: February 2025

Student activism has long been a pivotal force for social, political, and institutional change, particularly within the context of higher education. Grounded in Philip Altbach's theory of student activism, which emphasizes the socio-political and institutional conditions driving student movements, this article aims to examine the evolving nature and trends of student activism in contemporary society. Altbach's framework underscores the dual role of universities as both arenas of dissent and microcosms of broader societal conflicts. Building on this foundation, the article reconceptualizes student activism to address shifts in its focus, strategies, and outcomes. Three critical dimensions are explored: (1) the transformative impact of digital technologies on student mobilization, (2) the integration of intersectionality to confront global and systemic injustices, and (3) the tensions between collective action and individualism within neoliberal university environments. By synthesizing theoretical perspectives and empirical research, the article argues that traditional activism remains relevant but is increasingly complemented by digital activism, intersectional approaches, and responses to neoliberalism. This reconceptualization highlights student activism’s enduring significance as a catalyst for social change and its adaptability in addressing complex contemporary challenges. Situating these developments within Altbach's theoretical framework, the article provides fresh insights into the evolving role of student activism in higher education and its implications for scholars, policymakers, and institutional leaders
Talking About Infertility in Kenya: An Analysis of News Stories Posted on Social Media
Authors: Moore DaKysha , Onsomu Elijah O.
Published: February 2025

In many cultures, infertility is a health issue that is not discussed, especially in public. In Kenya, the fertility rate, slightly over 3 births per woman, has been in decline, and while some couples are deciding to have fewer children, some are diagnosed with infertility. African countries generally tend to have a low primary infertility rate but high secondary infertility rates; infertility is more common after a successful first birth. Because many health and social factors have relevance, this paper explores narratives about infertility in news videos posted on YouTube in Kenya. The researchers analyzed 20 videos that met the criteria: posted 7 years ago or less and less than 20 minutes long. Results reflect concerns about stigma, stress, and fertility treatment options. The implications are important for educating more couples about getting assistance for infertility
Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms
Authors: Zhang Xiao-Long , Jiang Yang-Yang , Chang Ying-Ying , Sun Yu-Li , Zhou Ying , Wang Yao-Hui , Dou Xiao-Tan , Guo Hui-Min , Ling Ting-Sheng
Published: February 2025

BACKGROUND

Recently, several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms (R-NENs). However, none of these methods can achieve 100% complete resection (CR), particularly in the vertical direction. Endoscopic full-thickness resection (EFTR) has proven to be an effective method for the treatment of submucosal tumors but is seldom utilized in the eradication of R-NENs.

AIM

To review cases of R-NENs removed using EFTR and to evaluate the safety and efficacy of this technique.

METHODS

This retrospective cohort study enrolled 160 patients with pathologically confirmed R-NENs, including 132 who underwent endoscopic submucosal dissection (ESD) and 28 who underwent EFTR. Lesions were categorized as < 1 cm, 1-2 cm, and > 2 cm in size. CR rate, en bloc resection rate, operation time, and complications were evaluated. Subgroup analyses and follow-up were also performed.

RESULTS

EFTR achieved 100% CR rates for lesions < 1 cm and 1-2 cm, compared with 67.0% and 50.0%, respectively, in the ESD group. En bloc resection and successful removal of the R-NENs were achieved in all patients. Meanwhile, EFTR showed performance comparable to ESD in terms of operation time, hospitalization cost, and postoperative adverse events, except for a one-day longer hospital stay. We also analyzed the invasion depth of R-NENs based on full-thickness specimens. The data showed that 80% of lesions (< 1 cm) and 85.7% of lesions (1-2 cm) had invaded the SM3 level or deeper at the time of resection. For ESD specimens, 46.6% (< 1 cm) and 89.3% (1-2 cm) of lesions had infiltrated more than 2000 μm beneath the muscularis mucosae.

CONCLUSION

EFTR has shown superior performance in the resection of small R-NENs compared with that of ESD.
Nab-paclitaxel plus capecitabine as a first-line regimen for advanced biliary tract cancers: Feasible or not feasible?
Authors: Chen Jian-Qiang , Lan Xiang
Published: February 2025

A clinical trial of nab-paclitaxel plus capecitabine as a first-line treatment for advanced biliary tract cancers was conducted. We analyzed the development of systemic therapy recommended by the National Comprehensive Cancer Network guidelines and the development of nab-paclitaxel combination chemotherapy for advanced biliary tract cancers (BTCs) and concluded that nab-paclitaxel plus capecitabine is a promising first-line regimen for advanced BTCs.
Lactococcus garvieae aggravates cholestatic liver disease by increasing intestinal permeability and enhancing bile acid reabsorption
Authors: Liu Man , Ji Ying-Lan , Hu Yu-Jie , Su Ying-Xi , Yang Jie , Wang Xiao-Yi , Chu Hong-Yu , Zhang Xue , Dong Shi-Jing , Yang Hui , Liu Yu-Hang , Zhou Si-Min , Guo Li-Ping , Ran Ying , Li Yan-Ni , Zhao Jing-Wen , Zhang Zhi-Guang , Piao Mei-Yu , Zhou Lu
Published: February 2025

BACKGROUND

Although an association between gut microbiota and cholestatic liver disease (CLD) has been reported, the precise functional roles of these microbes in CLD pathogenesis remain largely unknown.

AIM

To explore the function of gut microbes in CLD pathogenesis and the effects of gut microbiota on intestinal barrier and bile acid (BA) metabolism in CLD.

METHODS

Male C57BL/6J mice were fed a 0.05% 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet for 2 weeks to induce CLD. The sterile liver tissues of mice were then meticulously harvested, and bacteria in homogenates were identified through culture methods. Furthermore, 16S ribosomal DNA sequencing was employed to analyze sterile liver samples collected from eight patients with primary biliary cholangitis (PBC) and three control individuals with hepatic cysts. The functional roles of the identified bacteria in CLD pathogenesis were assessed through microbiota transfer experiments, involving the evaluation of changes in intestinal permeability and BA dynamics.

RESULTS

Ligilactobacillus murinus (L . murinus ) and Lactococcus garvieae (L. garvieae ) were isolated from the bacterial culture of livers from CLD mice. L . murinus was prevalently detected in PBC patients and controls, whereas L. garvieae was detected only in patients with PBC but not in controls. Mice inoculated with L. garvieae exhibited increased susceptibility to experimental CLD, with both in vitro and in vivo indicating that L. garvieae disrupted the intestinal barrier function by down-regulating the expression of occludin and zonula occludens-1. Moreover, L. garvieae administration significantly upregulated the expression of the apical sodium-dependent BA transporter in the terminal ileum and increased serum BA levels.

CONCLUSION

L. garvieae contributes to excessive BA-induced hepatobiliary injury and liver fibrosis by increasing intestinal permeability and enhancing BA reabsorption.
Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes
Authors: Lu Ming-Ying , Wei Yu-Ju , Wang Chih-Wen , Liang Po-Cheng , Yeh Ming-Lun , Tsai Yi-Shan , Tsai Pei-Chien , Ko Yu-Min , Lin Ching-Chih , Chen Kuan-Yu , Lin Yi-Hung , Jang Tyng-Yuan , Hsieh Ming-Yen , Lin Zu-Yau , Huang Chung-Feng , Huang Jee-Fu , Dai Chia-Yen , Chuang Wan-Long , Yu Ming-Lung
Published: February 2025

BACKGROUND

Insulin resistance, lipotoxicity, and mitochondrial dysfunction contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Mitochondrial dysfunction impairs oxidative phosphorylation and increases reactive oxygen species production, leading to steatohepatitis and hepatic fibrosis. Artificial intelligence (AI) is a potent tool for disease diagnosis and risk stratification.

AIM

To investigate mitochondrial DNA polymorphisms in susceptibility to MASLD and establish an AI model for MASLD screening.

METHODS

Multiplex polymerase chain reaction was performed to comprehensively genotype 82 mitochondrial DNA variants in the screening dataset (n = 264). The significant mitochondrial single nucleotide polymorphism was validated in an independent cohort (n = 1046) using the Taqman® allelic discrimination assay. Random forest, eXtreme gradient boosting, Naive Bayes, and logistic regression algorithms were employed to construct an AI model for MASLD.

RESULTS

In the screening dataset, only mt12361A>G was significantly associated with MASLD. mt12361A>G showed borderline significance in MASLD patients with 2-3 cardiometabolic traits compared with controls in the validation dataset (P = 0.055). Multivariate regression analysis confirmed that mt12361A>G was an independent risk factor of MASLD [odds ratio (OR) = 2.54, 95% confidence interval (CI): 1.19-5.43, P = 0.016]. The genetic effect of mt12361A>G was significant in the non-diabetic group but not in the diabetic group. mt12361G carriers had a 2.8-fold higher risk than A carriers in the non-diabetic group (OR = 2.80, 95%CI: 1.22-6.41, P = 0.015). By integrating clinical features and mt12361A>G, random forest outperformed other algorithms in detecting MASLD [training area under the receiver operating characteristic curve (AUROC) = 1.000, validation AUROC = 0.876].

CONCLUSION

The mt12361A>G variant increased the severity of MASLD in non-diabetic patients. AI supports the screening and management of MASLD in primary care settings.
Combined approach to strategic analysis of the financial condition of organizations
Authors:   North-Caucasus Federal University, E. V. Berezhnaya E. V. , Savtsova A. V. ,   North-Caucasus Federal University, Zelensky N. V. ,   North-Caucasus Federal University
Published: February 2025

Introduction. The matrix approach is one of the common analytical tools in economic science. Its application is not very limited, and it serves as a supplement to a number of other analytical tools. In particular, matrices are built on the basis of quantitative indicators of various aspects of corporate activity: market share, revenue, sales growth rates, etc. The paper puts emphasis on modeling using a combination of matrices and financial ratios of the financial strategy and financial policy of the company.

Goal. The paper develops a combined approach to the strategic analysis of the financial condition of organizations and their positioning using financial coefficients and matrices.

Materials and methods. The information base of the study included statistical materials from the SPARK database, financial statements of companies manufacturing chemical products in two types of activities. The proposed approach was tested using open data for 2022-2023. The authors modified the revenue / profit matrix by A. Slywotsky and D. Morrison. The interpretation of the indicators used for the matrix axes was proposed. They were processed into relative values in order to level out the influence of volumetric values on the analysis results. The indicators that characterize companies along the profit axis were clarified. Criteria values for determining high and low levels of revenue and profit were proposed and tested, and the shortcomings and prospects for their application were analyzed. The work is based on the works of economists in the field of finance and risk management, strategic analysis, and presents the development of the earlier works made by the authors.

Results and discussion. The authors tested the proposed combined approach to assessing the financial condition on the basis of a typical sample of chemical industry companies divided into two groups by the type of activity. Two types of average values were calculated in accordance with the general scientific concept of sustainability. Based on the approach used in the Bowman paradox, the distribution of companies in the industry was calculated depending on the level of their revenue and profit. At the end, using the example of several large companies, the problems and possibilities of assessing indicators within the framework of the matrix approach are shown.

Conclusion. Based on the results of the study, the authors made conclusions about the problems in the selected area and proposed directions for further research. In particular, it is advisable to further clarify the criteria boundaries for assessing the financial indicators used in the matrix and improve the set of indicators for assessment and the interpretation of the matrix cells.
A gaze into the void: Anticipatory saccades toward prevented events
Authors: Tonn Solveig , Teigeler Janna , Pfister Roland , Gamer Matthias
Published: February 2025

It is an open question how prevented events are represented in the human cognitive system—are they represented like produced events or are they represented in a different format? Here, we propose that seemingly contradictory observations on this question can be unified by assuming different time courses for production and prevention actions. Evidence from two experiments in the anticipatory saccades paradigm supported this model. Specifically, our results suggest that prevented events might be represented like produced events during action selection and execution, whereas their representation dissolves rapidly during action monitoring. In other words, the representation of prevented events reflects a two-step process: An initial affirmative representation is followed by later negation. Preregistrations, data, and analysis scripts for all experiments are available online (https://osf.io/m3veh/).
Sürdürülebilir Su Yönetimi Yağmur Suyu Hasadı ve Gri Su
Authors: Gürbüz Elif Rabia , Sahoo Satiprasad
Published: February 2025

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Pelatihan Ideasi dan Eksekusi Bisnis dalam Mengembangkan Kemampuan Kewirausahaan Generasi Muda
Authors: Hartono Wendra , Winarjo Alexander Jevan , Yusup Adi Kurniawan , Tambunan Damelina Basauli , Padmalia Metta
Published: February 2025

Program pengabdian masyarakat ini bertujuan untuk meningkatkan keterampilan kewirausahaan generasi muda melalui pelatihan yang bersifat interaktif dan aplikatif, yang dilaksanakan di Alfa Omega Church (AOC), Surabaya. Kegiatan ini melibatkan kolaborasi antara dosen dan mahasiswa Universitas Ciputra Surabaya dalam menyusun serta menyampaikan materi, seperti Bird in Hand Concept dan strategi pemasaran digital, yang dilengkapi dengan diskusi kelompok, pengisian lembar kerja, dan sesi praktik. Program ini dilaksanakan dalam dua sesi dengan pendekatan yang dirancang untuk membantu peserta menggali potensi diri, mengembangkan ide bisnis, dan mempersiapkan strategi eksekusi. Hasil kegiatan menunjukkan bahwa peserta mengalami peningkatan signifikan dalam pemahaman kewirausahaan, baik dari segi pola pikir maupun keterampilan praktis. Selain itu, kegiatan ini menciptakan suasana kolaboratif yang mendorong antusiasme serta partisipasi aktif peserta. Evaluasi menunjukkan bahwa program ini memberikan dampak positif, tidak hanya dalam membekali generasi muda dengan keterampilan yang relevan, tetapi juga dalam mendukung mereka untuk menghadapi tantangan ekonomi global. Program ini diharapkan dapat menjadi model dalam memberdayakan generasi muda melalui pendidikan kewirausahaan berbasis komunitas.
Unusual changes of suspicion report
Authors: Chystiakova Anastasia
Published: February 2025

The article is devoted to the study of the existing mechanisms for amending a notice of suspicion and atypical situations arising in connection with such amendments. Article 279 of the CPC provides for the only possible mechanism for changing the initial notice of suspicion. At the same time, in practice, atypical situations often arise in connection with the amendment of a notice of suspicion, which require clarification and more precise scientific specification. In particular, what situations in the amendment of a notice of suspicion are covered by the legal constructs «amendment of previously notified suspicion» and «new suspicion», and which of these constructs («new suspicion» or «amendment of previously notified suspicion») should be applied in cases where the initial notice of suspicion was not made in accordance with the procedure provided for by the CPC and the person did not acquire the status of a suspect as a result of the initial notice of suspicion, and whether the CPC provides for the possibility of re-drafting an identical/identical notice of suspicion.
Does the change of suspicion after the completion of the pre-trial investigation meet the requirements of the CPC? From what point should the pre-trial investigation period be calculated in the case of multiple notifications of suspicion, including amended ones, including those that were made in violation of the established procedure for such a notification in respect of the same person? The article is an attempt to provide answers to the following questions.
Keywords: pre-trial investigation, suspicion report, change of suspicion report, special subject, terms of pre-trial investigation.
Farklı Kültürlerde Çizgi Filmlerin Analizi
Authors: Yüzügüldü Melis Ay , Kavak Esra , Sarial Nisa Eylül
Published: February 2025

Bu çalışma, dört farklı çocuk animasyon dizisinin kültürel temalarını, değerlerini ve çocukların gelişimine olan etkilerini incelemektedir. "Pepee," "Caillou," "Heidi" ve "Maşa ile Koca Ayı" gibi popüler animasyonlar, farklı kültürlerden gelen yapımlar olmasına rağmen benzer sosyal ve duygusal gelişim temalarını işlemektedir. Çalışma, her bir çizgi filmin içerdiği kültürel değerleri, karakter yapılarını ve eğitimsel içeriklerini analiz ederek, çocukların sosyal becerilerinin, empati kurma yeteneklerinin ve sorun çözme becerilerinin nasıl şekillendiğine dair bulgular sunmaktadır. "Pepee," Türk kültürüne odaklanarak, çocuklara empati, toplumsal farkındalık ve aile bağlarının önemini öğretirken, "Caillou" çok kültürlü bir yaklaşım sergileyerek farklılıkları kabul etmeyi vurgulamaktadır. "Heidi," doğa sevgisi ve aile bağları üzerine yoğunlaşırken, "Maşa ile Koca Ayı" eğlenceli bir dil kullanarak çocukların sosyal becerilerini geliştirmeye yönelik bir yapım olarak dikkat çekmektedir. Bu çizgi filmlerin çocuklar üzerindeki etkisi, kültürel ve pedagojik bağlamda önemli bir yere sahiptir. Eğitimsel içerikleri, çocukların gelişimine katkı sağlamakta ve evrensel değerleri öğretmektedir. Ayrıca, her bir yapımın kültürel bağlamı, izleyicilere farklı bakış açıları sunarak kültürel çeşitliliğin önemini vurgulamaktadır. Çalışma, bu animasyonların çocukların erken yaşta öğrenmelerini destekleyici araçlar olarak işlev gördüğünü ve her birinin kendi kültüründe çocukların değer kazanımına katkıda bulunduğunu ortaya koymaktadır.
METABOLÓMICA DE POLYLEPIS RACEMOSA Y UTILIZACIÓN DEL EXTRATO ACUOSO DE SU TALLO EN LA SÍSTESIS DE NANOPARTÍCULAS DE PLATA
Authors: Román Ferreyra José Francisco , Monteza José , Santiago contreras Julio César
Published: February 2025

The green synthesis of silver nanoparticles (AgNPs) by the action of extracts of plant species has a promising future due to its multiple applications. In this work, we prepare AgNPs with an aqueous extract of Polylepis racemosa rhytidomes, a typical South American plant species whose phytochemistry has been little studied. The metabolomic study of this extract by UHPLC-MS allowed us to identify some organic acids, N-acetylglutamic acid, two glycosylated derivatives of ellagic acid (one of them is a new compound) and three glycosylated triterpenes. Aqueous extracts of Polylepis racemosa rhytidome with extraction times of 2, 6, 12 and 30 minutes were used for the synthesis of AgNPs. By SEM it was observed that the size of the AgNPs was approximately 12 nm, obtained with extracts of 2, 6 and 12 minutes. Finally, by comparing the scans by UHPLC-MS before and after the synthesis of AgNPs, and by the characteristics of the metabolites present, it is deduced that the organic acids of the extract stabilized the nanoparticles generated by the reducing groups present. It is concluded that the extract extraction time is an important study variable in the green synthesis of AgNPs with Polylepis racemosa rhytidome.