bluuebunny/crossref_metadata_2025 huggingface dataset:
Sequências e Séries: Conceitos e Aplicações
Authors: Arantes Gabriel Costa Vieira , Rodrigues Clóves Gonçalves
Published: July 2023

No presente estudo, são investigados os principais teoremas da Análise Real sobre sequências e séries numéricas, explorando as aplicações e contribuições destes resultados para diversos ramos da Física, com destaque para: padrões fibonaccianos da natureza, quasicristais, eletromagnetismo e energia média em um sistema quântico. Portanto, prezou-se por um método de investigação teórica, onde demonstra-se a obtenção de resultados fisicamente consistentes com observações experimentais, através do emprego dos teoremas da Análise Real, com todo o seu rigor matemático.
Cross-Cultural Understanding dan Deradikalisasi Agama: Studi Kasus Mahasiswa Pendidikan Bahasa Inggris IAIN Surakarta
Authors: Mulyono Tyas , Rifanan Arif , Muktiati Sarah , Annisa Dina Fitri , Yulianingsih Tri
Published: July 2023

This article aims to determine the role of subjects Cross-Cultural Understanding in an effort de-radicalization among students majoring inÂ English and optimize it to protect students from the influence of radical Islam. The collection of data carried out by interviewing several CCU lecturers in Islamic Education and Teacher Training Faculty IAIN Surakarta and distributing questionnaires to English Education students using Google Drive. Interviews indicate that this course has a close relationship with efforts to de-radicalization of Islam. As the results of the questionnaire indicate that 69.8% of students answered strongly agree Cross-Cultural Understanding courses teach to tolerate as an effort to reduce radical movements, hereby this course can be used by English educators to contribute in efforts to the de-radicalization program.Keywords:Cross-cultural understanding, Islamic radicalism, De-radicalization
Pengaruh Good Corporate Governance terhadap Internal Fraud pada Unit Usaha Syariah Tahun 2017
Authors: Raharjanti Ayu Irmasari
Published: July 2023

The fraud case has penetrated the world of Sharia banking, both Bank Umum Syariah (BUS) and Unit Usaha Syariah (UUS). Fraud involving banking companies, in the Good Corporate Governance (GCG) report, the bank only published the number of cases released> 100 million. This study uses 10 of the 20 UUS registered with the Financial Services Authority, the sample was obtained based on purposive sampling by looking at the publication of GCG reports on the banking site. Using the GCG self-assessment values processed by the simple SPSS 23 linear regression formula, it was found that Good Corporate Governance was not obtained against the Internal Fraud Unit of the Sharia Business.Keywords: Good Corporate Governance, Internal Fraud, Islamic, Finansial Institution.
IMPLEMENTASI PENDIDIKAN INKLUSI DI TK DESA MRANGGEN 01 SUKOHARJO
Authors: Khoyimah Ayu Nur , Khasanah Atina , Kultsum Umi
Published: July 2023

This research comes from combining normal childrenâ€™s learning in reguler classes with children with special needs in reguler schools and are now able to attend regular schools. Children with special need who initially could only go to special schools and are know able to attended regular schools with an inclusive education system. The purpose of this study was o determine the aplication of inclusive education in TK Mranggen Village 01, the research method used was describtive qualitative. The Research subjects were children with special needs, school principals and class teachers as weel as TK Mranggen Village 01. Data collection using observation and intervie techniquest. Yhan the data obtained were analysed and conlusions were drawn about the data that had been collected. The result of this study are that TK Mranggen Village 01 every years accept children with special need but obstacle to date is the curriculum us in 2013 method and infrastructure to serve children with special needs, and the luck of experience and knowladge special teacher to handle children with special needs.Keywords: inclusive school; children with special need
MODEL PENDAMPINGAN BELAJAR ORANG TUA UNTUK ANAK BERKEBUTUHAN KHUSUS SELAMA MASA PANDEMI
Authors: Rahmawati Tias , Fartiwi Fartiwi , Fatimah Umi Nur
Published: July 2023

Education is a basic right for every citizen, including children with special needs who need guidanceÂ from people who are experts in their fields. During the pandemic, children wereÂ required to study at home with guidanceÂ from their parents. The purpose of this study was to find outÂ the model of parental learning guidanceÂ for children with special needs during the pandemic. This research uses a case study method and data collection using interviews with thematic analysis. From the results of the study, there are three models of parent learning guidance for children with special needs during the pandemic, namely learning guidanceÂ using permissive, authoritarian, and authoritative parenting approaches.Keywords:Â children whit special needs; guiding study; pandemic
ANALISIS PERILAKU GENERASI MILENIAL DALAM PENGAMBILAN KEPUTUSAN INVESTASI SAHAM DI MASA PANDEMI COVID-19
Authors: Mahafani Devindha Fitria , Puspa Diah Maya , Khasanah Nurul , Wulandari Siti , Andriani Vivi
Published: July 2023

This study aims to analyze the behavior of the millennial generation in making stock investment decisions during the Covid-19 pandemic. This research method uses a qualitative method with a case study approach. The research subjects were four people who were included in the millennial generation category who were under 30 years old and domiciled in Solo Raya. The results of this study indicate that the behavior of investors in making stock investment decisions is based on the declining stock price trend due to the Covid-19 pandemic, influenced by the herding bias factor, namely following the actions or suggestions of others, but also analyzing the company's performance by looking at its financial statements.Keywords: Covid-19; Investor Behavior; Investment Decisions; Millenial Generation
ANALYSIS OF LANGUAGE STYLE IN NETFLIXID CAPTION AS SOCIAL GAP NEGOTIATOR IN ONLINE INTERACTION
Authors: Rohman Ahmad Mujibur , Alfatkhu Lusi Laksita , Mukarom Syahrul , Pratiwi Yuliana
Published: July 2023

Along with the development of science and technology, people start inventing many ways to interact. Presently, there have been created various many types of media in helping their communication activity, one of them is Instagram. This paper aimed to analyze the language styles used in NetflixId Instagram posts caption to interact with their audiences. This research is qualitative research and the data were collected by time-stamp from 8th August-31st August 2021. The researcher used a theory from Martin Joos (1976) about types of language styles. The results showed that there were 4 types of language styles that used in NetflixId Instagram account, they are: formal style (9 data), consultative (20 data), casual (61 data) and intimate (2 data). The caption dominantly used casual language style in writing their Instagram captions as a tool to interact with their audiences.Keywords: Instagram Caption; Language Style; NetflixId
PENGUKURAN ISLAMICITY PERFORMANCE INDEX (IPI) PADA KINERJA KEUANGAN BANK CENTRAL ASIA (BCA) SYARIAH PERIODE 2017-2021
Authors: Ayu Nurfallah Chandra , Nurtiasih Assyifa , Nur Diawati Suchehi , Ulfah Rufi Widya Janah Mirta , Sabita Putri Haura
Published: July 2023

Assets of Islamic financial institutions always increase from year to year. One of those that experienced an increase was Bank Central Asia (BCA) Syariah which experienced an increase of 9.5% in 2021 from the previous year with a nominal figure of 10,642.3 billion. There is a lot of general discussion in the community that Islamic banks are not much different from conventional banks. Some even think they have the same principle. Thus, this research needs to be done to determine the compliance of Islamic principles in BCA Syariah. This measurement is carried out using the Islamicity Performance Index (IPI) proposed by Hameed (2004). The research was conducted using quantitative methods with a descriptive approach. The results showed that the PSR and IIC ratios had the predicate "quite satisfactory" and "very satisfactory." Meanwhile, the EDR ratio and zakat performance are inversely proportional to the "very unsatisfactory" predicate. The DEWR ratio shows a gap between directors and employees 21-29 times during 2017-2021. This research can contribute to all stakeholders in BCA Syariah.

Keywords: BCA Syariah; Islamicity Performance Index; Sharia financial performance.
ANALISIS SPEAKING ANXIETY DALAM PROSES PEMBELAJARAN PADA MAHASISWA PBI SEMESTER 5 UIN RADEN MAS SAID SURAKARTA
Authors: Munawaroh Lailatul , Fitri Celviaulia , Kunti Anggela , Laila Siti Nur
Published: July 2023

This study is a qualitative study where the researcher aims to observe and analyze speaking anxiety in 5th semester English Education students at UIN Raden Mas Said Surakarta. This study adopts or uses data collection techniques in the form of interviews and questionnaires. Researchers collected 14 respondent data from students majoring in English Education in semester 5 who had undergone interviews and had filled out questionnaires. Because this research uses an qualitative approach, the data analysis technique used is qualitative descriptive non-statistical. The findings show that some of the main causes of speaking anxiety in students are self-confidence, lack of vocabulary and also lack of preparation. The results of this study contribute to the field of language teaching in terms of student factors, especially speaking anxiety during classroom learning. This study aims to apply the method of overcoming speaking anxiety in the learning process in the classroom, especially English Education.
Keywords: English Education; Speaking Anxiety; Students
ILMU KANTONG BOLONG R.M.P SOSROKARTONO DALAM PERSPEKTIF MORALITAS DAN IMPLEMENTASINYA PADA KEHIDUPAN MILENIAL
Authors: Thohari Ahmad Miftahudin , Faridatun Nisa Lia , Azizah Nur , Mutoharoh Rina , Aris Tantia Erdiana
Published: July 2023

Ilmu Kantong Bolong was one of the ideas propounded by R.M.P sosrokartono. It is the teaching that gives understanding to man that in life all the material riches that a man has should not be kept in tight order, but should always be directed to his fellowmen who need them. Wealth does not belong to absolute humans but only to those in need. Through literature studies (library research), it has been produced that in a moral perspective the doctrine of Ilmu Kantong Bolong contained the doctrine of humanity. It is that people should help one another and give to one another. So in its implementation of life today, successive generations can apply that moral teaching so as not to choose to be selfish and individualistic only for themselves.

Keywords: Ilmu Kantong Bolong; Sosrokartono; Morality, Milenials Generation
COVER SONG ANALYSIS OF SELECTED ONE DIRECTION PERFORMANCES IN THE X FACTOR UK SEASON 7
Authors: Chory Afri Andari
Published: July 2023

This research's purpose is to find out the type of cover songs sung by One Direction and the employment of ethnography of communication aspects shown from their performances. Two theories have been used to analyze this research's data: cover songs theory by Mosser (2008) and the ethnography of communication theory by Hymes (1972). The descriptive qualitative method is applied because it is aimed at comprehending a specific group case. The researcher herself and some helping tools such as; word processor, referential sources, and YouTube platform are this research's instruments. The data are taken from One Direction's selected performances in The X Factor UK Season 7. Data was obtained by watching selected One Direction performances, and interpretation was made by classifying and analyzing selected performances using the underlying theories. The results showed that One Direction mostly used the reduplication cover while singing the songs they had picked together. Besides, two other types of cover song, namely the interpretive cover, are also found, and it consists of major and minor interpretive cover. Six selected performances of One Direction in The X Factor UK Season 7 took place around October until December 2010 on The X Factor UK's stage, involving some performers and judges, and having both some patterns and specific behaviors shown from the singing turn by the members and the judges' way of commenting. In addition, the songs One Direction members have performed have several different tones that they successfully sing. The goals-oriented genre makes One Direction the 3rd winner of The X Factor UK Season 7.
Hebitren dan Pemberdayaan Ekonomi Pesantren di Soloraya
Authors: Aji Saputro  , Putri Ayu Kusuma Wardani  , Kharisma Desrianis Ramadani
Published: July 2023

The development of pesantren (Islamic boarding school) into opportunities as an economic improvement through empowerment is one of the efforts to be independent by joining HEBITREN. Apart from being a place to study about religion, pesantren has also be able to provide welfare and be independent in management. This study aims to determine the empowerment of pesantren through hebitren of Solo Raya in improving the economy. As the development of the era, the opportunity of pesantren in economy are also increased. The method used in this study is qualitative with a descriptive approach. The data of the study was collected through interviews and observations. The results show that the program carried out by hebitren in Solo Raya increased the efforts in improving the economy of pesantren in Solo Raya.
Marco general para la extracción de información y estimación de radiación solar diaria
Authors: Muñoz Torres Diego Fernando , Montoya Giraldo Oscar Danilo , Sabach Matos Sergio Arturo
Published: July 2023

Este articulo presenta un estudio comparativo resultado del diseño y simulación de un sistema de predicción de condiciones climáticas usando modelos de aprendizaje automático, en el cual, se confrontan los resultados obtenidos al usar una base de datos de condiciones ambientales, con otra base de datos generada a partir del tratamiento de los datos mediante el análisis por componentes principales. En la primera fase del estudio, se generan metadatos a través de los subespacios creados con el análisis por componentes principales, una segunda fase consta de elaborar un sistema de predicción de condiciones climáticas usando varios modelos de aprendizaje de máquina, los cuales, usarán como recurso los datos originales y los metadatos generados en la primera fase del estudio, en la fase final del estudio, se comparan ambos resultados con el objetivo de observar el comportamiento de los sistemas de inferencia de la radiación solar. La estrategia de tratamiento de datos propuesta permite extraer información de las bases de datos ambientales facilitando la interpretación y observación como serie temporal de datos, adicionalmente, se logra construir un marco de referencia experimental para la inferencia de la radiación solar usando diferentes técnicas de aprendizaje supervisado sobre las bases de datos generadas.
Entre pactos y censuras. El cuarto poder y el grupo Sonora (1920-1924)
Authors: Méndez Lara Francisco Iván
Published: July 2023

En mayo de 1920, tras el asesinato del presidente Venustiano Carranza, ascendió al poder el grupo Sonora, liderado por hombres de sectores medios que habían escalado políticamente gracias a la lucha armada. Uno de los retos principales de este grupo fue su relación con la prensa que todavía tenía entre sus filas a viejos carrancistas. Lejos de optar por la libertad de expresión, Álvaro Obregón y su secretario de Gobernación, Plutarco Elías Calles, censuraron y controlaron gran parte de los periódicos del país. Este artículo analiza la relación prensa-gobierno y las estrategias creadas desde el poder Ejecutivo para evitar que el “cuarto poder” se saliera de sus manos.
Presentación del dossier "Prensa, historia política y opinión pública en el siglo XX"
Authors: Sánchez Parra Sergio Arturo , Gil Pérez Anderson Paul , Correa Ramírez Jhon Jaime
Published: July 2023

El presente dossier surge del interés por desarrollar un espacio editorial en el que se pudieran articular diferentes preguntas, enfoques y temas de investigación que ponen en diálogo tres campos: la historia política, los estudios históricos de la prensa y la opinión pública. Las interacciones entre estos tres campos han sido muy visibles y significativas en las últimas décadas, renovando, sin duda, los horizontes de trabajo interdisciplinario entre profesionales de diversas disciplinas.
Influence of two vehicles for zinc oxide on zinc absorption through intact skin and wounds.
Authors: Agren M S
Published: July 2023

The zinc absorption from zinc oxide applied on intact and on wounded skin were compared using two vehicles: one containing gum rosin and the other containing hydrocolloids. After treatment of intact human forearm skin for 48 h, the zinc concentration was more than two-fold higher in the epidermis and interstitial fluid beneath the rosin vehicle than beneath the hydrocolloid vehicle. Systemic absorption of zinc through full-thickness rat skin wounds treated with zinc oxide increased significantly, however, with the use of the hydrocolloid vehicle. In vitro experiment indicated that the solubility of zinc oxide in buffered saline (pH 7.4) increased in the presence of hydrocolloids. The study, thus, indicates that rosin in combination with zinc oxide enhances the transport of zinc through intact human skin, and that hydrocolloids promote the zinc absorption through wounds.
Epidermal transglutaminase in the ichthyoses.
Authors: Van Hooijdonk C A , Steijlen P M , Bergers M , Mier P D , Traupe H , Happle R
Published: July 2023

Membrane-bound transglutaminase (TGm) is responsible for the cross-linking of proteins to form the cornified envelope. Since abnormalities have been reported in the envelope in certain ichthyoses, we have carried out a survey of TGm concentrations in scales from these disorders. Surprisingly, a striking and specific increase in enzyme activity was found in patients with non-erythrodermic autosomal recessive lamellar ichthyosis. It is not clear how this increase is related to the underlying recessive mutation.
A new staining method for visualization of keratin filaments in hair fibre cross sections.
Authors: Forslind B , Andersson M
Published: July 2023

A new method of staining the keratin filament matrix allowing a visualization of the filaments in cross section of hair fibres has been developed. It differs from previously published methods in that the hair fibres are neither fixed with OsO4 nor treated with sulfur bond breaking agents. High contrast is still obtainable in sections thicker than 60 nm.
Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate.
Authors: Agner T
Published: July 2023

Basal transepidermal water loss, skin thickness, blood flow and skin colour were examined before and after exposure of 28 patients with atopic dermatitis and 28 healthy controls to sodium lauryl sulphate. Transepidermal water loss was measured with an evaporimeter, skin thickness by ultrasound A-scanning, blood flow by laser Doppler flowmetry and skin colour by a chroma meter using the L*, a* and b* values, respectively. Patients with atopic dermatitis were found to have higher basal transepidermal water loss than controls (p less than 0.0001), and had an inclination towards an increased basal skin thickness (p = 0.056). No statistically significant differences were found with respect to basal blood flow or skin colour. The skin response to sodium lauryl sulphate was found to be statistically significantly increased in atopic patients compared with controls when evaluated by visual scoring and by increase in skin thickness, but not by increase in transepidermal water loss, blood flow or skin colour.
Patch tests with house dust mite antigens in atopic dermatitis patients: methodological problems.
Authors: Van Voorst Vader P C , Lier J G , Woest T E , Coenraads P J , Nater J P
Published: July 2023

Patch tests with house dust mite allergens were performed in 21 atopic dermatitis patients with a positive prick test and RAST for house dust mite. Variables in methodology of patch testing, i.e. allergen concentration, application time, and intensity of tape stripping, were studied. Tests were performed with Dermatophagoides pteronyssinus solutions containing 20X, 100X and 500X the prick test concentration and purified HDM antigen: 10 and 50 micrograms/ml P1Ag solution. The series was applied on 8X or 15X tape-stripped and clinically normal skin on the back during 24 and 48 h. Non-specific reactions due to tape stripping, fixation tape or patch test occlusion were frequently observed: after 15X tape-stripping in 3/7 (24-h application) and 6/7 (48-h application) patients, after 8X tape-stripping in 2/19 (24-h application) and 8/19 (48-h application) patients. Reactions clinically assessed as specific occurred in 6/21 (29%) atopic dermatitis patients, 4/6 occurring in the 10 patients with a serum IgE greater than 1000 kU/l. High allergen concentrations and 48 h of application increased the number of patients with specific reactions. If 15X tape-stripping had been omitted, 2/3 patients tested in this manner and showing specific test reactions would have been negative. Further conclusions regarding the value and the preferable method of patch testing with atopic allergens require an in vitro control test.
Release and absorption of zinc from zinc oxide and zinc sulfate in open wounds.
Authors: Agren M S , Krusell M , Franzén L
Published: July 2023

The pharmacokinetic behaviours of zinc oxide and zinc sulfate when applied as single doses to full-thickness excised rat skin wounds were studied. In the zinc oxide group, the wound fluid zinc concentration increased slightly over the 48-h postoperative period due to increased solubilization of zinc oxide, attributed to increased protein concentration of the wound fluid. When zinc sulfate was applied to the wounds, the wound fluid zinc concentration decreased rapidly during the first 4 postoperative h and then at a slower rate. The changes in the serum zinc level followed essentially the same kinetic pattern as that of the wound fluid zinc levels. The zinc concentration of the wounded tissue remained almost constant in zinc oxide treated wounds whilst it diminished in zinc sulfate treated wounds. In conclusion, zinc oxide delivers zinc ions to wounds over an extended period of time which results in constant wound tissue zinc levels. In contrast, zinc sulfate rapidly delivers zinc ions which results in decreasing tissue zinc levels.
Morbidity of Brown Recluse spider bites. Clinical picture, treatment and prognosis.
Authors: Ingber A , Trattner A , Cleper R , Sandbank M
Published: July 2023

A retrospective review was made of 35 cases of Brown Recluse spider bites treated during a period of 21 years. The most common location of the bite was on the lower limbs, particularly the thigh. The main systemic manifestations were fever, malaise and maculopapular rash, but there were no cases of hemolysis, coagulopathy, or of renal or neurologic involvement. Signs indicating a poor prognosis appeared to be lymphangitis, generalized maculopapular rash and location of the bite on the thigh or abdomen. Most cases were treated effectively by rest, elevation of the affected part of the body, local cleansing, and prophylactic antibiotics. On the basis of this experience it was concluded that only when lesions show a necrotic area measuring 2 to 3 cm should patients be treated with systemic corticosteroids. In most such cases, administration of corticosteroids for 14-21 days proved sufficient to avoid the need for surgery. Only 5 cases required surgical intervention.
A study of nineteen immunocompromised patients with extensive skin lesions caused by Pseudomonas aeruginosa with and without bacteremia.
Authors: El Baze P , Thyss A , Vinti H , Deville A , Dellamonica P , Ortonne J P
Published: July 2023

Nineteen immunocompromised patients with extensive skin lesions caused by Pseudomonas aeruginosa with or without P. aeruginosa bacteremia were analysed. Patients whose lesions originated in the skin were in the majority (14 patients). Skin lesions were located at the site of entry of bacteria (apocrine areas in 12 patients). Cutaneous lesions were pleomorphic but the typical picture of ecthyma gangrenosum was common in this group of patients. Only 2 of them developed P. aeruginosa septicemia and the prognosis was relatively good (7.5% mortality rate). These observations confirm that ecthyma gangrenosum may be a primary cutaneous disorder not systematically associated with bacteremia.
Uraemic gangrene syndrome.
Authors: Török L , Középessy L
Published: July 2023

Cutaneous gangrene and vascular calcinosis are described in a patient with chronic kidney failure and hyperparathyreodism. A review of 67 earlier described cases suggests that the symptoms constitute a unique syndrome.
Bullous pemphigoid treated by topical corticosteroids.
Authors: Paquet P , Richelle M , Lapiere C M
Published: July 2023

Three patients with bullous pemphigoid have been successfully treated with topical corticosteroids (clobetasol propionate) alone. Another patient required adjuvant systemic corticosteroid therapy. In view of its minimal side effects, we confirm a previous report that topical corticosteroid therapy could represent a valuable alternative in the treatment of limited bullous pemphigoid, although for its extensive forms, such therapy may be incomplete.
A hydrocolloid occlusive dressing plus triamcinolone acetonide cream is superior to clobetasol cream in palmo-plantar pustulosis.
Authors: Kragballe K , Larsen F G
Published: July 2023

The purpose of this study was to compare the therapeutic efficacy of a hydrocolloid dressing (Actiderm) over a medium strength corticosteroid (triamcinolone acetonide (TAA) 0.1% cream) with that of a highly potent corticosteroid (clobetasol propionate 0.05% cream) in palmo-plantar pustulosis and localized pustular psoriasis. It was a randomized, open, prospective, right-left comparative trial in 19 patients. The Actiderm dressing and the TAA cream were applied every third day, whereas the clobetasol cream was applied twice daily for 4 weeks. Both treatments resulted in a significant improvement. On completion of treatment, complete clearance was found in 13 patients (63%) with Actiderm plus TAA, but in only 3 patients (21%) with clobetasol (p = 0.001). Four weeks after stopping therapy, the clinical parameters had returned to their pre-treatment level, except for erythema on the Actiderm plus TAA treated lesions (p less than 0.05). No clinically important adverse effects were reported or observed in particular there was no sign of skin atrophy at the end of study. The results of this study demonstrate that Actiderm applied over a medium strength corticosteroid every third day is highly effective against palmoplantar pustulosis and localized pustular psoriasis. However, it is necessary to develop treatment regimens to maintain the improvement achieved.
Effect of 1,25-dihydroxyvitamin D3 on adenylate cyclase and protein kinase C in pig epidermis.
Authors: Koizumi H , Yasui C , Ohkawara A
Published: July 2023

1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is suggested to be involved in the regulation of keratinocyte proliferation and differentiation. Recent evidence also indicates its potential value for the treatment of psoriasis, where the alteration of various transmembrane signalling systems has been well documented. Using porcine epidermis, we investigated the effect of 1,25(OH)2D3 on adenylate cyclase and protein kinase C systems, both of which are markedly altered in the psoriatic hyperproliferative epidermis. The effect was compared with that of another anti-psoriatic agent, hydrocortisone. Neither 1,25(OH)2D3 nor hydrocortisone revealed any effect on cyclic AMP levels or adenylate cyclase responses of epidermis. Long-term (24 h) hydrocortisone treatment, however, resulted in increased beta-adrenergic-, and prostaglandin E-adenylate cyclase responses. 1,25(OH)2D3-treatment had no effect on the epidermal adenylate cyclase responses following 24 h of incubation. The addition of both 1,25(OH)2D3 and hydrocortisone to the incubation medium resulted in the attenuation of the hydrocortisone-induced beta-adrenergic-, and prostaglandin E-adenylate cyclase responses of the epidermis. Neither agent had any effect on the cholera toxin-induced and forskolin-induced cyclic AMP accumulations of the epidermis. Neither 1,25(OH)2D3 nor hydrocortisone had any effect on the epidermal protein kinase C activity. It has been suggested that various anti-psoriatic agents might reveal their effect through the modulation of the adenylate cyclase system. Since 1,25(OH)2D3 had no effect when it was added singly to the incubation medium and rather inhibited hydrocortisone-induced adenylate cyclase stimulation, it is suggested that 1,25(OH)2D3 reveals its therapeutic efficacy through the mechanism, probably independently of the adenylate cyclase system.
Cutaneous innervation in chronic renal failure patients. An immunohistochemical study.
Authors: Fantini F , Baraldi A , Sevignani C , Spattini A , Pincelli C , Giannetti A
Published: July 2023

Most chronic renal failure patients suffer from generalized pruritus. An involvement of cutaneous nerve terminals in the pathogenesis of uremic pruritus has been suggested. Skin specimens from 24 uremic patients and 10 healthy subjects were processed with an indirect immunofluorescence method to investigate the presence and distribution of a number of neuronal markers and neuropeptides. No difference was found between the two groups in the distribution pattern of the positive nerve fibres. However, a reduction in the total number of skin nerve terminals in the uremic patients was detected. No correlation could be found between the immunohistochemical findings and the clinical features. Our results suggest that the skin innervation is altered in most chronic renal failure patients, possibly as a consequence of neuropathy.
Werner's syndrome: no difference in in vitro life span of dermal fibroblasts from proximal and distal parts of the body.
Authors: Kondo S , Hozumi Y , Aso K
Published: July 2023

Recently it has been reported that fibroblasts from distal parts of the body of a patient with Werner's syndrome grew poorly in vitro as compared with those from the proximal part of the same patient. To confirm this observation, cultures of fibroblasts from different parts of the body were set up in 2 cases of Werner's syndrome, but no significant difference in life span was observed. Fetal calf serum (FCS) and fibroblast growth factor (FGF) stimulated growth of fibroblasts from different body parts equally well. These data indicate that there is no difference in growth activity of fibroblasts from proximal and distal body parts in patients with Werner's syndrome. Moreover, the growth rate of epidermal outgrowths did not differ significantly between proximal and distal parts of these patients.
Regional distribution of melanocytic naevi in relation to sun exposure, and site-specific counts predicting total number of naevi.
Authors: Augustsson A , Stierner U , Rosdahl I , Suurküla M
Published: July 2023

The role of exposure to ultraviolet light in the formation of melanocytic naevi was analysed by investigating the regional naevus distribution in 310 subjects (30-50 years) from a Swedish census file. The lateral aspect of the arms and the back had the largest concentration of naevi. The mean naevus count per unit surface area was higher in intermittently exposed than in rarely exposed skin (p less than 0.001), while the lowest mean count was found in chronically exposed skin. These results support the idea that intermittent exposure to ultraviolet light has a "naevogenic" effect while chronic exposure might be protective. Dysplastic naevi had a distribution pattern quite different from common naevi. Considering the distribution pattern solely, dysplastic naevi seem to develop independently of exposure to ultraviolet light. The numbers of naevi in different skin areas were tested for their power in predicting the total body naevus count. The strongest correlations were found between total counts and counts on the anterior surface of the thighs and the lateral aspect of the arms. Counts from any of these areas will provide a practical and satisfactory estimate of the total number of naevi.
Acne in pubertal boys undergoing treatment with androgens.
Authors: Fyrand O , Fiskaadal H J , Trygstad O
Published: July 2023

In the present study, the development of acne lesions was studied in boys deemed to be too tall, for which they were treated with injections of androgens. In a retrospective and a prospective group of pubertal boys, an increased incidence of acne was observed as a consequence of treatment with androgens.
Correlation between cutaneous sarcoidosis and systemic sarcoidosis.
Authors: Rodionov A N , Samtsov A V
Published: July 2023

Twenty patients with cutaneous sarcoidosis and 21 patients carrying isolated skin sarcoids were studied. (We use the term 'sarcoid' to emphasize that exclusively skin was altered.) Both groups were compared by clinical and histological patterns and certain data concerning the state of the mononuclear phagocyte system (MPS). It was found that skin lesions in sarcoids and sarcoidosis do not differ regarding either in clinical or histological manifestations. The changes in the functional activity of monocytes and macrophages were the same. The data obtained allow us to suggest that sarcoids should be regarded as a systemic disease connected with changes in the MPS reaction.
Expression of beta-2 integrin molecules on human keratinocytes in cytokine-mediated skin diseases.
Authors: Simon M Jr , Hunyadi J , Dobozy A
Published: July 2023

Integrins are cell surface molecules of importance in a wide variety of cellular functions, including morphogenesis, cell migration and cell matrix interactions. The beta-2 (B2) integrin (leukocyte integrin, CD11/CD18) subfamily comprising three members, each consisting of a shared beta subunit (CD18) non-covalently associated with unique alpha subunits (CD11a, CD11b, CD11c). In the present study, we have analysed the expression pattern of B2 integrins on the surface of human keratinocytes (HKs) in biopsies obtained from healthy volunteers, from positive tuberculin skin tests and from patients with acute urticaria (AU), lichen planus (LP), psoriasis vulgaris (PV), mycosis fungoides (MF) or purpura pigmentosa chronica (PPC). In biopsies obtained from positive tuberculin tests and from the clinically involved skin of patients with LP, PV, MF or PPC, a multifocally occurring, suprabasal peroxidase-positive reaction was observed on the membranes of the HKs when the monoclonal antibodies (MABs) Dako CD11a, Dako-p150, 95 or Dako CD18 were used. In contrast, no specific staining of the HKs was observed with the same MABs in biopsies from healthy volunteers, from patients with AU and in the uninvolved skin specimens obtained from the other patients. The HKs from PV, LP, MF, PPC and AU patients and those from the healthy subjects failed to give a positive reaction when the MAB against CD11b (OKM1) was used. Our present findings provide further evidence that HKs may be actively involved in cell adhesion processes.
Pityrosporum ovale and atopic dermatitis in children and young adults.
Authors: Broberg A , Faergemann J , Johansson S , Johansson S G , Strannegård I L , Svejgaard E
Published: July 2023

Children aged 0-21 years, 60 children with atopic dermatitis (AD), 40 children with rhinoconjunctivitis and or asthma (RA) and 40 children with no atopic history (HC) were studied to evaluate the relationship between skin colonisation with Pityrosporum ovale and the occurrence of specific IgE antibodies to P. ovale. The following studies were done: culture for P. ovale, measurement of IgE antibodies to P. ovale (skin prick test, RAST), Candida albicans, and Cladosporium herbarum (RAST) and IgG antibodies to P. ovale. P. ovale could be cultured with about the same frequency in children and young adults with AD and age-matched children with or without other atopic manifestations. In spite of similar colonisation, IgE antibodies against P. ovale occur only in atopy and more frequently in children with AD than in those with other types of atopic disease.
A demographic survey of leg and foot ulcer patients in a defined population.
Authors: Lindholm C , Bjellerup M , Christensen O B , Zederfeldt B
Published: July 2023

By means of a questionnaire sent to all medical units in Malmö, including primary care, homes for the elderly, and industrial health clinics, 275 patients with leg and foot ulcers were identified. With a population of 232,908 in Malmö, this corresponds to a prevalence of 0.12%, which is lower than reported by others. Since the response rate was high (88% total, Primary Care: 100%), the prevalence of 0.12% is, however, believed to be real and might be explained by the urban area investigated, with easy access to care and proximity to one somatic hospital. 50% of the patients with leg and foot ulcers were treated in Primary Care, and 30% of the leg ulcer patients were treated at the Department of Dermatology. 88% of leg and foot ulcer patients were over 75 years of age. Median age was 79.5 years, with 80 for women and 76.5 for men. In Primary Care the median age was 82. There was a predominance of women in the study population with an overall sex ratio of 3:1. A higher proportion of patients living alone was found in Primary Care. The etiology of the ulcers was considered to be "unknown" or "other" or else no statement was given in 36% of the leg ulcer- and 22% of the foot ulcer patients. This might reflect an overall uncertainty about the underlying etiological cause. Medially and laterally located leg ulcers were reported equally often, but there was also a great proportion of wholly or partially circumferential ulcers. 76% of the foot ulcers were located on the toes.(ABSTRACT TRUNCATED AT 250 WORDS)
A defective purine nucleotide synthesis pathway in psoriatic patients.
Authors: Kiehl R , Ionescu G
Published: July 2023

Purine nucleotide concentrations in skin- and blood-cells of psoriatic patients are abnormal: The increase in the steady state level of cGMP and the decrease in the cAMP concentrations are associated with an enhanced rate of cellular proliferation. Concomitantly we found in the present study decreased ADP and ATP concentrations in blood cells (p less than 0.0001). The change in nucleotide concentrations suggests a defective purine nucleotide synthesis pathway. Stimulation of the Krebs cycle with fumaric acid raises ATP (p less than 0.0001) and most probably cAMP levels and at the same time slows down the purine nucleotide synthesis through end-product inhibition. Both effects can inhibit DNA and protein synthesis activity, which results in inhibition of cellular proliferation. Fumaric acid seems therefore a useful treatment for psoriatic lesions if liver and kidney functions (purine nucleotide and urea cycle) are controlled during treatment.
Alterations of skin microcirculatory rhythmic oscillations in different positions of the lower extremity.
Authors: Gniadecki R , Gniadecka M , Kotowski T , Serup J
Published: July 2023

Microcirculatory vasomotion is considered to be an important mechanism promoting and facilitating the transfer of blood cells through skin capillaries. Since skin vulnerability of the leg is closely associated with gravitational factors and skin micro-circulation, we investigated by a laser Doppler apparatus influence of postural changes on skin blood flow oscillations in lower limbs of healthy volunteers. Our data show a marked decrease in microcirculatory oscillation amplitudes at a frequency 7.6 (+/- 0.6) min-1 after lowering the leg. This could be reversed by the application of compressive bandage. Our study points toward a potentially important mechanism of microcirculatory impairment during orthostasis.
A new kind of skin lesion in Behçet's disease: extragenital ulcerations.
Authors: Azizlerli G , Ozarmağan G , Ovül C , Sarica R , Mustafa S O
Published: July 2023

A new skin lesion was encountered in 29 of 970 Behçet's patients. The lesions resembled oral aphthae clinically, were recurrent and left a scar tissue like genital ulcers but were located extragenitally. Skin biopsies could be done in only 4 cases and they all showed vasculitis.
Extraskeletal osteochondroma in the finger. Mimicking the fourth phalangeal bone.
Authors: Nogita T , Kawakami M
Published: July 2023

A 36-year-old Japanese woman with an extraskeletal osteochondroma in the left thumb is reported. A roentgenogram showed a calcified tumor, located at the distal portion of the left distal phalanx, which mimicked the fourth phalangeal bone. The pathogenesis might in this case be hamartomatous.
Acute mercury intoxication with lichenoid drug eruption followed by mercury contact allergy and development of antinuclear antibodies.
Authors: Schrallhammer-Benkler K , Ring J , Przybilla B , Meurer M , Landthaler M
Published: July 2023

A 31-year-old black man was examined for evaluation of a suspected occupational disease. Three years earlier he had been suffering from acute mercury intoxication during work in a mercury recycling factory. Skin symptoms then had been a lichenoid drug eruption, patchy alopecia and stomatitis, which had all disappeared rapidly after systemic glucocorticosteroid treatment. The examination revealed positive patch test reactions to metallic mercury and inorganic mercury compounds, an elevated titre of serum antinuclear antibodies and normal IgE levels. The induction of antinuclear antibodies by mercury has been shown in animal experiments. It can be hypothesized that this patient, who may have had an increased individual susceptibility, became allergic to mercury by the mercury intoxication.
Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes.
Authors: Arenberger P , Kemény L , Süss R , Michel G , Peter R U , Ruzicka T
Published: July 2023

Polymorphonuclear leukocyte (PMNL) infiltration is an important characteristic in psoriatic lesions. The proinflammatory 8-kD peptide interleukin-8 (IL-8) is present in psoriatic scales and possesses a high chemotactic activity on human neutrophils, which may relate to its role in psoriasis. Its chemotactic activity is mediated via specific receptors on PMNL. The goal of our work was to ascertain whether PMNL infiltration in psoriasis can be accounted for by functional abnormalities of the circulating PMNL due to alterations in the IL-8 receptor density or affinity (or both). Results of radioligand binding studies performed in 10 psoriatic patients, 10 patients with atopic eczema and 11 normal controls showed no difference in receptor affinity (Kd) between the groups. However, a slight but significant elevation in IL-8 receptor density was seen on PMNL from psoriatic individuals (31,230 +/- 3,237 binding sites per cell) compared to those from normal volunteers (24,152 +/- 2,643) and atopic eczema patients (24,092 +/- 2,743). Increased number of IL-8 receptors may, besides elevated cutaneous IL-8 concentrations, contribute to the intraepidermal accumulation of PMNL in psoriasis.
Methotrexate hepatotoxicity in psoriatic patients submitted to long-term therapy.
Authors: Themido R , Loureiro M , Pecegueiro M , Brandão M , Campos M C
Published: July 2023

Eighty-four patients with severe psoriasis who required methotrexate (MTX) therapy have been reviewed. A total of 134 liver biopsies were performed. The lack of correlation between alcohol intake and the use of potential hepatotoxic drugs with pretreatment liver biopsies is noted. A review of 30 patients who had liver biopsies performed before and after MTX treatment showed no statistically significant difference between the histological grades before and after treatment. Nor was there any absolute correlation between the cumulative MTX doses and the histological changes of follow-up biopsies. In this group of patients, 15 (50%) developed fibrosis, which was severe in 2 patients, after 3,431 mg MTX average dose. Cirrhosis was observed in 3 patients (10%) after 1,667 mg MTX average dose. Follow-up liver biopsies are recommended for patients treated with MTX.
A new case of Zimmermann-Laband syndrome with atypical retinitis pigmentosa.
Authors: Koch P , Wettstein A , Knauber J , Zaun H
Published: July 2023

This paper reports a case study of a 10-year-old girl exhibiting symptoms of a Zimmermann-Laband syndrome (ZLS), including an ocular involvement not previously observed. In addition to the case reported, we have also discovered 21 patients described in the literature. Major clinical findings, defined as being present in more than 75% of the cases under discussion, are presented.
Expression of loricrin in skin disorders.
Authors: Juhlin L , Magnoldo T , Darmon M
Published: July 2023

Loricrin, the major component of the cornified envelope, is normally expressed in the granular layer of epidermis during the last steps of keratinocyte differentiation. Using an antiloricrin antiserum (A8-73), an increased expression of this envelope precursor was found in some disorders of hyperorthokeratosis (ichthyosiform erythroderma lichen ruber), but not in others (keratodermia ichthyosis vulgaris). In disorders accompanied by parakeratosis, a sign of incomplete differentiation (psoriasis, prurigo nodularis) loricrin was not detected, whereas the tissue expressed filaggrin. Treatment of normal skin with retinoic acid, increasing epidermal thickness in some subjects, led to an increased expression of loricrin. Loricrin might be a useful indicator of the extent of terminal epidermal differentiation in skin disorders.
Adenosine deaminase activity in sera of patients with psoriasis, mycosis fungoides and adult T cell leukemia.
Authors: Koizumi H , Ohkawara A
Published: July 2023

Adenosine deaminase activities in sera were measured in 18 psoriatic patients, 8 mycosis fungoides patients, and 9 patients with adult T cell leukemia. Adenosine deaminase activity in the sera of the psoriatic patients showed no significant increase. An elevated adenosine deaminase activity was observed in 7 of the 8 patients with mycosis fungoides and 8 of the 9 patients with adult T cell leukemia. After chemotherapy, adenosine deaminase activity in serum of acute adult T cell leukemia was reduced. Adenosine deaminase activity in the sera of 2 patients with smoldering adult T cell leukemia was more elevated, with exacerbation of the disease. It is difficult to grade the extension of the tumors in plaque stage mycosis fungoides and smoldering adult T cell leukemia. To know the progression of the disease is critical in determining its management. These results indicate that adenosine deaminase activity in serum is one of the reliable indicators for the grading of mycosis fungoides and adult T cell leukemia.
Nickel contact sensitivity in the guinea pig. An efficient open application test method.
Authors: Nielsen G D , Rohold A E , Andersen K E
Published: July 2023

Nickel contact sensitivity was successfully induced in guinea pigs using an open epicutaneous application method. Immediately after pretreatment with 1% aqueous sodium lauryl sulfate, upper back skin was treated daily for 4 weeks with 0.3%-3% nickel sulfate in either a 1% lanolin cream (Vaseline, pH 5 SAD crème) or hydroxypropyl cellulose. Weekly intradermal injections with aluminium potassium sulfate were used as adjuvant. The animals were challenged twice with a one week interval, with nickel sulfate 2% in water and 1% in petrolatum, respectively. The response rates in the test groups treated with nickel sulfate 1% or 3% in the lanolin cream or 1% in hydroxypropyl cellulose were significantly different from the response rate in the control group. Considering both readings at both challenges, the frequency of sensitization was 57-93% (8 of 14 to 13 of 14 animals) in the group treated with 1% in the lanolin cream, 60-100% (9/15 to 15/15 animals) in the group treated with 3% in the lanolin cream, and 67-75% (8/12 to 9/12 animals) in the group treated with 1% in hydroxypropyl cellulose. Rechallenge of initially sensitized animals 10 weeks later confirmed that a lasting contact allergy had been obtained.