bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Different Pulsing Solutions on Postharvest Life of Tuberose (Polianthes tuberosa L.) cv. Prajwal
Authors: Srivastava Vishal , Kumar Satendra , Malik Sunil , Kumar Mukesh , Singh Shishu Pal , Singh Bhim
Published: November 2023

Tuberose flower (Polianthes tuberosa L.) is a perennial and bulbous flowering plant, related to the Amaryllidaceae family and now it is placed in family Agavaceae. The investigation entitled “Influence of different pulsing solutions on postharvest life of tuberose (Polianthes tuberosa L.) cv. Prajwal” was carried out at the experimental farm and laboratory of Department of Floriculture and Landscape Architecture, College of Horticulture, SVPUAT, Meerut during the year of 2021-22 & 2022-23. Experiment was laid out in Completely Randomized Design with 10 treatments and 3 replications. In the present experiment we aimed at prolonging the vase life and improving the quality of cut spike of tuberose by Pulsing or hydration procedure using different noble treatments in tuberose, as the main challenge was to reduce abscission of buds, initiation of bud opening mechanism and leaf yellowing due to the sensitivity, vascular infections, high rate of respiration and inhibition of ethylene production. These differences in physiological behavior of cut stem dipped in different pulsing solution are very important to consider when developing post harvest physiology of tuberose. In the present finding we have primarily focused and observed under the light of pertinent literature available substantiated with robust evidence thus we derived the overall best treatment for different parameters for improving the vase life of tuberose that were recorded under the treatment T9 (Sucrose 15% + 8-HQC 300 ppm) followed by the treatment T6 (Sucrose 10% + 8-HQC 300 ppm) and T8 (Sucrose 15% + 8-HQC 200 ppm) resulted in most of the postharvest parameters such as amount of pulsing solution consumed (13.16, 15.82 ml), days taken to opening of floret (2.53, 2.54 days), floret diameter (3.38, 3.40 cm), vase life (10.78, 10.80 days), weight change/loss in cut spike (13.29 %, 14.52 %), fungal infection, fragrance score (2.95, 2.96), freshness index (4.97, 4.98) and moisture content (89.89, 85.60, 83.21%).
Advances for Improving Phosphorus Use Efficiency in Agriculture
Authors: Chaudhari Sonali , Zinzala Vallabh
Published: November 2023

An impending crisis is the continuous availability of phosphate fertilizers, which underlie global food production. The rock phosphate deposits on which the world depends are not only finite but many are polluted and many are located in geopolitically unstable locations, implying that significant changes will be required to maintain food supply for an increasing global population. There is no single solution, but a combination of phosphorus management measures is required not just to extend the life of the remaining non-renewable rock phosphate sources, but also to result in a more efficient, sustainable phosphorus cycle. Improving the effectiveness of fertilizer applications to agricultural land, as well as a better understanding of phosphorus cycling in soil-plant systems and the interplay between soil physics, chemistry and biology in conjunction with plant characteristics are among the solutions. The finite nature of rock phosphate supply and the development of other sources of phosphorus fertilizers is unavoidable. There are clear prospects and it is now critical to prioritize a concerted effort to increase phosphorus usage efficiency.
Study on Determining the Blood Glucose Concentration During an Intravenous Injection Using Volterra Integral Equations
Authors: Khidir Ahmed A. , Alfaifi Waad I. , Alsharari Salihah L. , Alanazi Ibtisam M. , Alyasi Lujain S.
Published: November 2023

In this study, the mathematical model for determining the blood glucose concentration during an intravenous injection has been solved throw Volterra integral equation and using Chebyshev spectral method. The method is based on the blending of the Chebyshev pseudo spectral method and its implementation procedure reduces the Volterra integral equation to a system of algebraic equations that are easy to solve. For the practical application of the method, a mathematical model in medical science for determining the blood glucose concentration during an injection has been solved. Tables and figures  were generated to verify the accuracy and convergence of the method. The results demonstrate that the method is efficient, convergent and accurate to the exact solution.
An In silico Analysis Study of the Chemical Compounds from the Crassulaceous Plant Bryophyllum pinnatum (Lam.) Oken against the SARS-COV-2 Proteases
Authors: Souza Maycon Douglas Araújo , Souza Hellen Cris Araújo , Viana Edilanne Katrine Amparo , Alves Sabrina Kelly Silva , Sousa Cássio Silva , Ribeiro Arthur Serejo Neves , Vale Vanessa de Sousa do , Rocha Jefferson Almeida
Published: November 2023

Introduction: Acute severe respiratory syndrome SARS-COV-2, a member of the coronavirus family of enveloped RNA viruses, is the disease-causing agent of COVID-19. Research has been done on the active components of medicinal plants that have therapeutic promise. In this regard, the goal of this work was to investigate the anti-SARS-CoV-2 activity of compounds from the plant Bryophyllum pinnatum (Lam.) Oken.

Materials and Methods: The methodology involved the selection of chemical constituents from the plant leaves in the Pubchem database, in addition to obtaining the protein structures of SARS-CoV-2 (6VXX, 6LU7, 1R42) from the Protein Data Bank (PDB). Docking was carried out using Autodock Tools 1.5.6 and Autodock Vina, with LigPlus for amino acids and Chimera v.13.1 for 3D structures. The most promising compounds were chosen, and the pkCSM tool was used to assess their absorption, distribution, metabolism, excretion and toxicity (ADMET) characteristics.

Results: 264 molecular connections were made from the evaluation of 66 chemical components, 21 of which had binding energies that were less than -8.9 kcal.mol-1. The chemical bryotoxin B produced the highest findings with an interaction energy of -9.9 kcal.mol-1 with the Spike protein, indicating its potential as a SARS-CoV-2 inhibitor. These results are encouraging, but more in vitro and in vivo research is needed to validate the effectiveness of COVID-19 treatments.

Conclusion: The molecular docking study shows promising compounds such as Bryotoxin B, β-amyrin acetate and diosmin in B. pinnatum, with high levels of key proteins of SARS-COV-2. ADMET predictions and these compounds were also developed, indicating the therapeutic potential of B. pinnatum as COVID-19 inhibitors.
Harlequin Ichthyosis: A Rare Skin Disorder
Authors: Palandurkar Pooja , Jain Doulisa , Wankhade Pavankumar
Published: November 2023

Harlequin ichthyosis, an exceptionally rare and severe genetic skin disorder, presents a unique intersection of genetics, skin biology, and clinical manifestation. This congenital condition, a severe form of ichthyosis, has captivated the medical community due to its striking clinical features. It arises from genetic mutations in the ABCA12 gene, disrupting skin barrier formation. The clinical presentation is characterized by diamond-shaped scales, facial distortions, and medical challenges, particularly in neonates. Historical accounts have contributed to our evolving understanding, culminating in recent genetic advancements. While no cure exists, treatment involves a combination of medical interventions and supportive care. The psychosocial impact on affected individuals and families is profound. Despite challenges, the future is promising, driven by genomics, precision medicine, novel therapies, and collaborative research. Harlequin ichthyosis represents a remarkable example of progress at the intersection of science and compassion.
Anti-Inflammatory Activity of Ethanol Leaf Extract of Arthropteris Orientalis in Wistar Albino Rat
Authors: Omoighele Akhigbe Faith , Anusiem Ckikere A. , Ghasi Samuel I. , Akpotu Ajirioghene E. , Ezerioha Chidi E. , Funso Funso-Babarimisa,
Published: November 2023

The study investigated the anti-inflammatory activity of ethanol leaf extract of Arthropteris orientalis in wistar albino rat. The plant extract was obtained with the procedure as described by Khalifa et al. [1] and both acute and chronic anti-inflammatory properties was assessed. Five groups of five animals each were utilized for acute and chronic inflammation respectively. Anti-inflammatory effect of the extract was evaluated on egg albumin induced paw edema in albino rats and edema induced by formalin in the wistar albino rats’ paw for acute and chronic inflammation respectively. The extract had 26.665% tannin while flavonoid, saponin, phenol, and glycoside had 0.784%, 0.631%, 0.183% and 0.057% respectively. The result revealed that the extract at 500 mg/kg exhibited significant inhibition (p<0.05) of systemic acute paw edema at the 4th hour of the second phase of edema in comparison with the standard drug. The results reveal that intraperitoneal administration of ethanol leaf extract of Arthropteris orientalis on formalin-Induced paw edema in wistar albino rats at (100 and 500mg/kg) and (100mg/kg) exhibited significant inhibition (p<0.05) in mean paw volumes on day 1 and 2 respectively. The extract did not produce any significant hematological change. These results show that Arthropteris orientalis has potential anti-inflammatory properties.
REVIEW OF TOTAL QUALITY MANAGEMENT CONCEPT
Authors: Prajogo Daniel Indarto
Published: November 2023

The definition of TQM continues to be a debated issue to organizational management. Not only is there an absence of a uniform definition but also there is no prescriptive standard outlining TQM concepts. This supports an argument that TQM is not merely a tool or method that is ready for use, but there is a set of underlying principles, philosophies and paradigms that must be applied in the unique organizational context. This paper will discuss the concept of TQM at three integrated levels in an organization from inside out; namely paradigm level, system and structural level and technical and operational level in the purpose for helping organizations to grasp the comprehensive substance of TQM.
MODEL MATEMATIK UNTUK MENENTUKAN NILAI TUKAR MATA UANG RUPIAH TERHADAP DOLLAR AMERIKA
Authors: Halim Siana , Adelia Shirley , Rahardjo Jani
Published: November 2023

The main objective of this paper is to estimate parameters in the heteroskedasticity models, particularly in Auto Regressive Conditional Heteroskedasticity - ARCH(1) and Generalized Autoregressive Conditional Heteroskedasticity- GARCH(1,1). These models will be used to fit, to forecast and to update the volatility of Rupiah Vs US.Dollar rate.

In order to get the estimation of fitting and updating parameters of ARCH(1) and GARCH(1,1), here will be used iterative method which is derived from the standard maximum likelihood estimation and the initial values are taken from the result of Yule Walker Estimation. The updating parameters will be estimated by using the approach of ARIMA(p,d,q) updating parameters models.

The heteroskedasticity models will give a good fitting even a good forecast in near stasioner condition, however this models can not detect the jump that can be happend due to the changes of political situation that happend in Indonesia.

Abstract in Bahasa Indonesia :

Tujuan utama dari penelitian ini adalah untuk menentukan nilai estimasi pada parameter-parameter yang terdapat pada model-model heteroskedastik, khususnya dalam Auto Regressive Conditional Heteroskedasticity - ARCH(1) dan Generalized Autoregressive Conditional Heteroskedasticity- GARCH(1,1). Model-model ini akan digunakan untuk menentukan, meramalkan dan memperbaharui nilai parameter dari nilai tukar mata uang Rupiah terhadap Dollar Amerika.

Nilai estimasi pada model ARCH(1) dan GARCH(1,1) diperoleh dengan metode iteratif yang diturunkan dari estimasi maksimum likelihood baku dan nilai awalnya didapat dari pendekatan Yule Walker. Penentuan nilai parameter yang diperbaharui akan diestimasi dengan menggunakan pendekatan model ARIMA(p,d,q).

Model-model heteroskedastik memberikan nilai pendekatan nilai tukar yang baik bahkan memberikan nilai peramalan yang baik pula, namun demikian model ini belum dapat mendeteksi terjadinya loncatan yang terjadi yang diakibatkan oleh perubahan situasi politik di Indonesia.

Kata kunci: ARCH, GARCH, YWE, MLE, Heteroskedasticity
PENGGUNAAN TEKNIK DAN ALAT KUALITAS DALAM PROSES PERBAIKAN DAN PENINGKATAN KUALITAS
Authors: Prajogo Daniel Indarto
Published: November 2023

The use and application of quality tools and techniques as means for improving quality and performance in an organization has been widely known since people saw the success of their applications at Japanese firms. It is interesting to note that those quality tools and techniques are simple and most of them do not require highly formal educational background to use them. Ironically, instead of their simplicity experience has shown that many companies have failed in gaining benefits when trying to use those tools. Those failures are mainly because managers do not realize that the value of the tool is derived from the conditions of use. If the environment does not provide a set of conditions in which it is rational and beneficial to use the tool, then it will not be seen as having value and will not be used. This paper will briefly discuss several important aspects and factors which need attention as prerequisites for the use of quality tools and techniques so they can produce real, maximum and long term benefits.

Abstract in Bahasa Indonesia :

Penggunaan alat dan teknik kualitas sebagai sarana untuk meningkatkan kualitas dan kinerja perusahaan telah dikenal secara luas sejak orang melihat keberhasilan penerapannya perusahaan-perusahaan di Jepang. Yang menarik adalah bahwa alat dan teknik kualitas tersebut adalah sesuatu yang sederhana dan kebanyakan tidak memerlukan latar belakang pendidikan formal yang tinggi untuk dapat menggunakannya. Ironisnya adalah di balik kesederhanaan alat-alat tersebut pengalaman menunjukkan bahwa banyak perusahaan telah gagal untuk mendapatkan manfaat ketika mereka mencoba menggunakan alat-alat tersebut. Kegagalan ini terutama disebabkan karena para manajer tidak menyadari bahwa manfaat dari alat-alat tersebut bergantung pada kondisi pemakaiannya. Bila lingkungan tidak berada pada kondisi yang rasional dan menguntungkan bagi penggunaan alat tersebut, maka tidak akan pernah terlihat hasil yang nyata dari penggunaan alat-alat tersebut Tulisan ini akan membahas secara singkat beberapa aspek dan faktor penting yang perlu diperhatikan sebagai prasyarat penggunaan alat dan teknik kualitas agar menghasilkan manfaat yang nyata, maksimal dan berdampak untuk jangka panjang.

Kata kunci: alat, teknik, pelatihan
PERANCANGAN SISTEM SELEKSI JURNAL YANG AKAN DILANGGAN PERPUSTAKAAN
Authors: Tjandra Stevanus Adrianto , Linggawati Henny , Soetanto Tessa Vanina
Published: November 2023

The purpose of this research is to design a selection system for the journals subscribed by Petra Christian University Library. The designed selection system takes into account both technical and economical criteria. In applying the Multi Criteria Analysis in this research, a Multi Atribute Decision Making, that is the Analytic Hierarchy Process technique, is used. The total amount produced later becomes the objective function coefficient from the Binary Integer Linear Programming model with the constraints of the total available budget of the jurnal acquisition.

Abstract in Bahasa Indonesia :

Penelitian ini dilakukan untuk merancang suatu sistem seleksi jurnal yang akan dilanggan oleh perpustakaan Universitas Kristen Petra. Sistem seleksi yang dirancang memperhitungkan baik kriteria-kriteria teknis maupun ekonomis. Dalam melakukan analisis kriteria ganda ini digunakan suatu teknik Multi Atribute Decision Making, yaitu : teknik AHP (Analytic Hierarchy Process). Bobot keseluruhan yang dihasilkan selanjutnya menjadi koefisien fungsi tujuan dari model Binary Integer Linear Programming dengan kendala jumlah anggaran pengadaan jurnal yang tersedia.

Kata kunci: analytis hierarchy process, kriteria teknik dan ekonomis, binary integer linear programming
RANCANGAN DATABASE SUBSISTEM PRODUKSI DENGAN PENDEKATAN SEMANTIC OBJECT MODEL
Authors: Yuliana Oviliani Yenty
Published: November 2023

To compete in the global market, business performer who active in industry fields should have and get information quickly and accurately, so they could make the precise decision. Traditional cost accounting system cannot give sufficient information, so many industries shift to Activity-Based Costing system (ABC). ABC system is more complex and need more data that should be save and process, so it should be applied information technology and database than traditional cost accounting system. The development of the software technology recently makes the construction of application program is not problem again. The primary problem is how to design database that presented information quickly and accurately. For that reason it necessary to make the model first. This paper discusses database modelling with semantic object model approach. This model is easier to use and is generate more normal database design than entity relationship model approach.

Abstract in Bahasa Indonesia :

Dalam persaingan di pasar bebas, para pelaku bisnis di bidang industri dalam membuat suatu keputusan yang tepat memerlukan informasi secara cepat dan akurat. Sistem akuntansi biaya tradisional tidak dapat menyediakan informasi yang memadai, sehingga banyak perusahaan industri yang beralih ke sistem Activity-Based Costing (ABC). Tetapi, sistem ABC merupakan sistem yang kompleks dan memerlukan banyak data yang harus disimpan dan diolah, sehingga harus menggunakan teknologi informasi dan database. Kemajuan di bidang perangkat lunak mengakibatkan pembuatan aplikasi program bukan masalah lagi. Permasalahan utama adalah bagaimana merancang database, agar dapat menyajikan informasi secara cepat dan akurat. Untuk itu, dalam makalah ini dibahas pemodelan database dengan pendekatan semantic object model. Model data ini lebih mudah digunakan dan menghasilkan transformasi yang lebih normal, jika dibandingkan dengan entity relationship model yang umum digunakan.

Kata kunci: Sub Sistem Produksi, Semantic Object Model, Database Relational.
APPLICATION OF FUZZY COGNITIVE MAPS ON POLICY ANALYSIS: DETERMINING THE POLICY OF SUPPORTING THE ACADEMIC SPIN OFFS
Authors: P. Soetanto Danny
Published: November 2023

Fuzzy Cognitive Map (FCM) is a type of artificial neural network. It can be viewed as a weighted directed graph in which vertices represent concepts and edges represent causal links between them. An FCM can be used as an intelligent decision support system (DSS) tool. It works by representing important issues in a given situation and their causal relationships. The evolution of a dynamic system with time can be simulated and the behavior of the systems can be predicted and explained using an FCM. In this case FCM is used to ditermine the policy to support the academic spin off. Simulation brings forth some conclusions and the best policy can be chosen.
PROCUREMENT IN MANUFACTURING ORGANISATION: PORTFOLIO AND THE USE OF THE INTERNET
Authors: Pujawan I Nyoman
Published: November 2023

Procurement function in manufacturing organisations has played significantly more critical roles nowadays than in the past. The contribution of procurement function is much determined by how well the procurement management system is designed. A critical aspect of managing procurement function in order to optimise its contribution to the organisation is procurement portfolio, i.e., categorisation of items and then differentiation of procurement focus for different categories. This paper will discuss procurement portfolio as a basis for procurement manager to optimise the contribution of his/her function in supporting the organisation's objectives. The role of electronic procurement in each category of the portfolio will also be discussed.
SYSTEM DESIGN AND BEHAVIOR OF PATTERN RECOGNITION OF CONTROL CHART USING NEURAL NETWORK
Authors: Halim Justin Yulius
Published: November 2023

Recognition of unnatural patterns in control charts is important to get more understanding about the process problem. Shewhart control chart can recognize shift pattern only, while the others cannot be detected by this chart. Neural networks were proposed by many researchers to achieve the better recognition of the patterns. A system of neural networks needs to be fitted to this problem by realizing the behaviors of control charts. Each behavior will affect the development of each part of the system. Some problem need to be pointed also when dealing with the patterns of the control chart.
CASE STUDIES OF USE OF DESIGN OF EXPERIMENTS IN MATERIAL RESEARCH
Authors: Roy Salil Kumar , Sutapa I Nyoman
Published: November 2023

The paper describes principles of factorial and fractional factorial design of experiments. The various ways of analysing data obtained by these procedures are shown via four case studies. Yates method was followed in case 1 where the effect of anode type, carbon content of steel, temperature, and agitation on cathodic protection of steel in seawater, on current density, was studied. In case 2, a glass was formulated within 10 constituante melted, quantity water and tested for flow caracteristics, from the result the factor effect was calculated. In case 3, analysis of results is done in a very simple way. In this case, the effect of carbon content, surface condition, temperature, and agitation on the corrosion of steel in seawater was studied. In case 4, the effect of eleven constituents on acid resistance of a cast iron enamel has been studied through sixteen experimental compositions. This case gives a method to find out which of the sixteen experimental compositions is nearest to a target value.
A FUZZY-BASED DECISION MAKING APPROACH FOR PRODUCT CONCEPT SELECTION
Authors: Febransyah Ade , Utarja J. Bely
Published: November 2023

Selecting the best product concept is one of critical tasks in product development process. Making decisions at this stage becomes very difficult due to imprecise and uncertain product requirements. This paper presents the framework of product concept selection that integrates the fuzzy set theory and the analytic hierarchy process (AHP). In the proposed approach, the fuzzy membership function is employed in performing "pairwise comparison" between competing alternatives and a "reference" on each of the criteria. The use of a reference is due to the difficulty in consistently comparing concepts to one another. The comparisons are also used to obtain the relative importance of criteria with respect to the overall objective. Once pairwise comparisons are completed, vector aggregates are computed through the use of an original AHP method and fuzzy arithmetic operations. A numerical example is presented to illustrate the approach.
PRODUCT DATA MANAGEMENT DALAM KAITAN DENGAN CAD/CAM
Authors: Yahya Bernardo Nugroho
Published: November 2023

The future industry is the one who can manage the information system. Today, communication technology and distributed system computerization already have the ability to implement system that able to exchange and share information between different users. Product Data Management (PDM) is an up-to-date and excellent method on managing the exchange and share of information. PDM is able to integrate and manage data analyzing process and documentation of the related product component physically. By adjusting the CAD/CAM on certain condition, the PDM will function maximally by using the information based on STEP (Standard for the Exchange of Product Data model). This article will explain the relationship between PDM system and CAD/CAM on industry.

Abstract in Bahasa Indonesia :

Sistem informasi merupakan ujung tombak sebuah perusahaan yang unggul di masa depan. Komputerisasi dengan sistem yang terdistribusi dan teknologi komunikasi saat ini memiliki kemampuan untuk mengimplementasikan sistem yang dapat menukar dan men-share informasi antar user yang berbeda. Teknologi yang mendapat cukup perhatian luas dalam hal pertukaran dan sharing informasi ini adalah Product Data Management (PDM). PDM dapat mengintegrasikan dan mengatur proses pengolahan data dan dokumen teknik yang berhubungan dengan komponen fisik produk yang bersangkutan. PDM akan berfungsi maksimal apabila kesesuaian dengan CAD/CAM diatur sedemikian rupa, dihubungkan dengan informasi berbasiskan STEP (Standard for the Exchange of Product Data model). Artikel ini akan menjelaskan hubungan antara sistem PDM dengan CAD/CAM dalam industri.

Kata kunci: PDM, Manajemen Data, CAD/CAM, STEP.
What Are Pituitary Adenomas?
Authors: Voelker Rebecca A.
Published: November 2023

This JAMA Patient Page describes the types and symptoms of pituitary adenomas and their diagnosis and treatment.
We Grieve Too
Authors: Taylor Mallory R.
Published: November 2023

In this narrative medicine essay, a pediatric oncologist grapples with the emotions of loss and guilt while attending the memorial service of her 8-year-old patient.
Adverse Event Reporting in Randomized Clinical Trials for Multiple Myeloma
Authors: Najjar Mimi , McCarron John , Cliff Edward R. Scheffer , Berger Katherine , Steensma David P. , Al Hadidi Samer , Chakraborty Rajshekhar , Goodman Aaron , Anto Eric , Greene Tom , Sborov Douglas , Mohyuddin Ghulam Rehman
Published: November 2023

Importance

Cancer treatment can result in burdensome toxic effects that profoundly affect patient quality of life. In seeking to emphasize the efficacy of tested treatments, clinical trial reports may use subjective or minimizing terms to describe adverse events (AEs).

Objective

To evaluate patterns of AE reporting in multiple myeloma (MM) randomized clinical trials (RCTs) published between 2015 and early 2023.

Design, Setting, and Participants

For this cohort study, the PubMed, Embase, and Cochrane Central Register of Controlled Trials databases were searched to assess the prevalence of minimizing terms in MM RCTs published between January 1, 2015, and March 1, 2023. Minimizing terms were defined as subjective terms used to favorably describe the safety profile of the intervention. The terms searched included convenient, manageable, acceptable, expected, well-tolerated, tolerable, favorable, and safe. Final data analysis was performed on July 21, 2023.

Main Outcomes and Measures

The primary outcome was the occurrence of at least 1 minimizing term in an article. Univariate logistic regression analyses were performed to evaluate the association between the presence of at least 1 minimizing term and the actual incidence of grade 3 or 4 AEs, serious AEs, or grade 5 AEs.

Results

Of the 65 RCTs included, 56 (86%) used minimizing terms when describing treatment-emergent AEs. The most frequently used minimizing terms were well-tolerated or tolerable in 29 trials (45%), manageable in 18 (28%), and acceptable in 16 (25%). Grade 3 or 4 AE rate in the examined RCTs ranged from 23% to 94%, with a median of 75% (IQR, 59%-82%). A univariate regression analysis demonstrated no association between the use of minimizing terms and grade 3 or 4 AE rates (odds ratio [OR], 1.35 [95% CI, 0.88-2.10] per 10% AE rate increase; P = .17) or grade 5 AE rates (OR, 3.16 [95% CI, 0.27-12.7] per 10% AE rate increase; P = .45).

Conclusions and Relevance

These findings suggest that trial investigators and sponsors regularly use minimizing terms to describe toxic effects in MM trials, and use of this terminology may not reflect actual AE rates in these studies. Instead of using these terms, trial investigators should highlight event rates and patient-reported outcomes, to allow clinicians and patients to better evaluate the true tolerability of AEs.
Unveiling the Double‐Edged Behavior of Controlled Selenium Substitution in Cobalt Sulfide for Balanced Na‐Storage Capacity and Rate Capability
Authors: He Tingting , Zhao Weiming , Hu Junping , Deng Chengjiang , Yan Dong , Huang Shaozhuan
Published: November 2023

Transition metal sulfide‐based anodes usually suffer from huge volumetric change and sluggish reaction kinetics, hindering their application for long‐term and high‐power/energy sodium‐ion batteries. Herein, a new design of CoS2‐xSex (0≤x≤2) nanocrystals with highly controllable selenium substitution and S, Se‐codoped graphene immobilization (CoS2‐xSex@SG) is proposed to tune the reaction kinetics and structural stability. The nanocrystal‐on‐graphene structure and robust C─S &C─Se bonding rivets between CoS2‐xSex and SG greatly improve the structural stability of the CoS2‐xSex@SG. Electrochemical performance, kinetic analysis, and theoretical calculation reveal that Se substitution plays a double‐edged role in sodium storage: the increase of Se substitution content enhances the Na+ diffusion kinetics but decreases the Na‐storage capacity. When the Se substitution content is 0.4, the CoS1.6Se0.4@SG electrode demonstrates the best performance: high initial Coulombic efficiency (95.5%), ultrahigh rate capability (412.8 mAh g−1 at 30 A g−1), and ultra‐stable cycling performance (97.6% capacity retention after 1000 cycles). In situ/ex situ measurements further unveil that the conversion reaction between Co0 and Na2S/Na2Se generates the micro‐scaled CoSe2–CoS2 heterostructure, synergistically improving the Na‐storage active sites and reaction kinetics. This work provides a controllable anion substitution strategy to balance the Na+ storage active sites and kinetics with potential applications for high‐power/energy sodium‐ion batteries.
Full‐Color Generation via Phototunable Mono Ink for Fast and Elaborate Printings
Authors: Lee Yun Hyeok , Song Won Jun , Park Jae‐Man , Sung Gimin , Lee Min‐Gyu , Kim Miji , Park Sungeun , Lee Ju Sang , Kim Miyoung , Kim Wook Sung , Sun Jeong‐Yun
Published: November 2023

Unlike pigment‐based colors, which are determined by their molecular structure, diverse colors can be expressed by a regular arrangement of nanomaterials. However, existing techniques for constructing such nanostructures have struggled to combine high precision and speed, resulting in a narrow gamut, and prolonged color fabrication time. Here, this work reports a phototunable mono ink that can generate a wide range of colors by controlling regularly arranged nanostructure. Core–shell growth controlled by polymerization time precisely regulates the distance between arranged particles at a nanometer‐scale, enabling the generation of various colors. Moreover, the wide and thin arrangement induces constrained out‐of‐plane growth, thus facilitating the intricate color generation at the desired location via photopolymerization. Upon terminating polymerization by oxygen gas, the generated colors are readily fixed and kept stable. Utilizing programmed ultraviolet illumination, large‐scale and high‐resolution (≈1 µm) full‐color printings are demonstrated at high speed (100 mm2 s−1).
Inkjet Printing of Pharmaceuticals
Authors: Carou‐Senra Paola , Rodríguez‐Pombo Lucía , Awad Atheer , Basit Abdul W. , Alvarez‐Lorenzo Carmen , Goyanes Alvaro
Published: November 2023

Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer‐by‐layer, to create 3D objects or 2D patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever‐evolving demands of personalized medicine in the healthcare industry. Although originally developed for nonhealthcare applications, IJP harnesses the potential of pharma‐inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma‐inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D‐printed materials, showcasing their diverse advantages, while exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in an era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient‐specific treatment is on the horizon of becoming a tangible reality.
Nd─Nd Bond in Ih and D5h Cage Isomers of Nd2@C80 Stabilized by Electrophilic CF3 Addition
Authors: Yang Wei , Velkos Georgios , Rosenkranz Marco , Schiemenz Sandra , Liu Fupin , Popov Alexey A.
Published: November 2023

Synthesis of molecular compounds with metal–metal bonds between 4f elements is recognized as one of the fascinating milestones in lanthanide metallochemistry. The main focus of such studies is on heavy lanthanides due to the interest in their magnetism, while bonding between light lanthanides remains unexplored. In this work, the Nd─Nd bonding in Nd‐dimetallofullerenes as a case study of metal–metal bonding between early lanthanides is demonstrated. Combined experimental and computational study proves that pristine Nd2@C80 has an open shell structure with a single electron occupying the Nd─Nd bonding orbital. Nd2@C80 is stabilized by a one‐electron reduction and further by the electrophilic CF3 addition to [Nd2@C80]−. Single‐crystal X‐ray diffraction reveals the formation of two Nd2@C80(CF3) isomers with D5h‐C80 and Ih‐C80 carbon cages, both featuring a single‐electron Nd─Nd bond with the length of 3.78–3.79 Å. The mutual influence of the exohedral CF3 group and endohedral metal dimer in determining the molecular structure of the adducts is analyzed. Unlike Tb or Dy analogs, which are strong single‐molecule magnets with high blocking temperature of magnetization, the slow relaxation of magnetization in Nd2@Ih‐C80(CF3) is detectable via out‐of‐phase magnetic susceptibility only below 3 K and in the presence of magnetic field.
Machine Learning in Bioelectrocatalysis
Authors: Huang Jiamin , Gao Yang , Chang Yanhong , Peng Jiajie , Yu Yadong , Wang Bin
Published: November 2023

At present, the global energy crisis and environmental pollution coexist, and the demand for sustainable clean energy has been highly concerned. Bioelectrocatalysis that combines the benefits of biocatalysis and electrocatalysis produces high‐value chemicals, clean biofuel, and biodegradable new materials. It has been applied in biosensors, biofuel cells, and bioelectrosynthesis. However, there are certain flaws in the application process of bioelectrocatalysis, such as low accuracy/efficiency, poor stability, and limited experimental conditions. These issues can possibly be solved using machine learning (ML) in recent reports although the combination of them is still not mature. To summarize the progress of ML in bioelectrocatalysis, this paper first introduces the modeling process of ML, then focuses on the reports of ML in bioelectrocatalysis, and ultimately makes a summary and outlook about current issues and future directions. It is believed that there is plenty of scope for this interdisciplinary research direction.
Nature‐Inspired Electrocatalysts for CO2 Reduction to C2+ Products
Authors: Xu Linlin , Trogadas Panagiotis , Coppens Marc‐Olivier
Published: November 2023

The electrocatalytic reduction reaction of carbon dioxide (CO2RR) has gained significant attention as a promising approach to mitigate carbon dioxide emissions and generate valuable chemicals and fuels. However, the practical application of CO2RR has been hindered by the lack of efficient and selective electrocatalysts, particularly to produce multi‐carbon (C2+) products. Nature serves as an ideal source of inspiration for the development of CO2RR electrocatalysts, as biological organisms can efficiently catalyze the same reaction and possess robust structures that are inherently scaling. In this review, recent advances in the nature‐inspired design of electrocatalysts for CO2RR to C2+ products are summarized and categorized based on their inspiration source, including the coordination sphere of metalloenzymes and the cascade reactions within the enzyme, as well as the local environment. The importance of understanding the fundamental mechanisms and the different contexts between nature and technological application in the design process is highlighted, with the aim to improve the nature‐inspired design of electrocatalysts for CO2RR to C2+ products.
Hydroxy‐ or chlorine‐anchored Pt single‐atom in Al2O3: Which is better for propane dehydrogenation?
Authors: Yang Yanpeng , Liu Qiang , Wang Jingnan , Li Panpan , Miao Chenglin , Liu Jianliang , Yang Yijun , Wang Jieguang , Wang Xi
Published: November 2023

Platinum‐based single‐atom catalysts (Pt1 SACs) can significantly improve the catalytic activity for propane dehydrogenation (PDH) because of their elevated atomic utilization. However, maintaining the high‐temperature stability of the Pt1 species is of utmost importance. To answer the key question: Hydroxy‐ or chlorine‐anchored Pt1 single atoms in Al2O3: Which is the better choice for PDH? We have designed two types of single‐atom Pt catalysts on Al2O3 via a surface group trapping strategy: Pt1–Al2O3 with isolated Pt–O species and Pt1Cl1–Al2O3 with isolated Pt–Cl species. When tested in PDH, Pt1Cl1–Al2O3 showed an exceptional activity of 145 molpropene molPt−1 min−1 at 600°C, which was 3.8 times higher than that of Pt1–Al2O3. It has been demonstrated that the isolated Pt–Cl species in Pt1Cl1–Al2O3 act as an active site and undergoes a dehydrogenation pathway with a lower energy barrier, while Pt1 in Pt1–Al2O3 undergoes a dissociation‐desorption pathway, resulting in few propene productions.
On Cemetery Hill: The legacy of burials at Clemson University, a public university in the southern USA
Authors: Seramur Keith C. , Campbell Kyle B. , Anderson Joseph B. , Cowan Ellen A.
Published: November 2023

Ground‐penetrating radar (GPR) was used to map anomalies characteristic of unmarked graves on the grounds of the modern Woodland Cemetery on the campus of Clemson University. Hundreds of these anomalies are believed to represent newly discovered unmarked graves belonging to African Americans including enslaved people, convicted laborers, sharecroppers, domestic workers, tenant farmers and wage workers, who contributed to the wealth of the Fort Hill Plantation or to building and maintaining the university. These burials appear to be in an organized arrangement indicating the presence of a burial ground where the graves would have been marked at the time of internment. Analyses of reflections from the bottom of the grave shaft detected horizontal bases as well as possible chambered and vaulted burials, a common vernacular burial type among African Americans in the 19th and early 20th centuries. A fewer number of graves showed hyperbolic reflections that can be produced by graves that contain coffins or a large artefact. This may indicate burial practices that changed over time or the status of the interred individual. The estimated length of the grave shaft in GPR grid data suggests that small adults or adolescents made up most of the burials (58%), then adults (28%) and infants and children (13%). In 1924, Woodland Cemetery was developed on Cemetery Hill, which had its first recorded burial in 1837. Plots were then gifted to prominent University leaders, faculty, staff and their families. The unmarked burials were found juxtaposed among these modern graves requiring modification of the current protocol for the operating cemetery to preserve the sacred space and to prevent destruction of these burials. This work affirms ongoing efforts by this public university to address its origins from a plantation and segregation in the American South.
Kidney Outcomes and Preservation of Kidney Function With Obinutuzumab in Patients With Lupus Nephritis: A Post Hoc Analysis of the NOBILITY Trial
Authors: Rovin Brad H. , Furie Richard A. , Ross Terres Jorge A. , Giang Sophia , Schindler Thomas , Turchetta Armando , Garg Jay P. , Pendergraft William F. , Malvar Ana
Published: November 2023

Objective

To determine whether adding obinutuzumab to standard‐of‐care lupus nephritis (LN) therapy could improve the likelihood of long‐term preservation of kidney function and do so with less glucocorticoids.

Methods

Post hoc analyses of the phase II NOBILITY trial were performed. Time to unfavorable kidney outcome (a composite of treatment failure, doubling of serum creatinine, or death), LN flare, first 30% and 40% declines in estimated glomerular filtration rate (eGFR) from baseline, and chronic eGFR slope during the trial were compared between patients with active LN who were randomized to take obinutuzumab (n = 63) or placebo (n = 62) in combination with mycophenolate mofetil and glucocorticoids. The number of patients who achieved complete renal response (CRR) on 7.5 mg or less per day of prednisone was also determined.

Results

Obinutuzumab reduced the risk of developing the composite kidney outcome by 60%, LN flare by 57%, and first eGFR decline of 30% or 40% by 80% and 91%, respectively. Patients receiving obinutuzumab had a significantly slower decline in eGFR than patients receiving placebo, with an annualized eGFR slope advantage of 4.1 ml/min/1.73 m2/year (95% confidence interval 0.14–8.08). Overall, 38% of patients receiving obinutuzumab compared with 16% of patients receiving placebo achieved CRR at week 76 while receiving 7.5 mg or less per day of prednisone (P < 0.01); at week 104, the difference did not achieve significance (38% vs 22%; P = 0.06).

Conclusion

Post hoc analyses of NOBILITY demonstrated that compared with standard‐of‐care therapy, obinutuzumab treatment resulted in superior preservation of kidney function and prevention of LN flares. More patients achieved CRR at week 76 with less glucocorticoid use in the obinutuzumab group.

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Phytoremediation: A Shift Towards Sustainability for Dairy Wastewater Treatment
Authors: Agrahari Sakshi , Kumar Sushil
Published: November 2023

Dairy processing industries have emerged as the most swiftly evolving sectors with excessive wastewater generation containing proteins, fat, oils, greases (FOGs), etc. As there is rising strain on energy usage and dependence on water resources, sustainable research focuses on reduction in wastewater generation and developing value‐added goods. An effective and widely explored sustainable technique for treating wastewater is phytoremediation, a plant‐based process. This review aims to analyze phytoremediation as a sustainable alternative for dairy wastewater treatment. It initially briefs about dairy wastewater characteristics and treatment alternatives and discusses constructed wetlands and hydroponic system in detail with mechanism insights and influenced process parameters. Interconnected technologies with phytoremediation and their impact on contaminant transformations, nutrient reuse, and detoxification of pollutants are encompassed. Also, resource recovery and biomass utilization, feedstock enrichment along with the future prospects of integrated hydroponic systems for achieving sustainability with efficient resource recovery are featured.
Enzymatic Synthesis of Diterpenoids from iso‐GGPP III: A Geranylgeranyl Diphosphate Analog with a Shifted Double Bond
Authors: Li Heng , Dickschat Jeroen S.
Published: November 2023

The analog of the diterpene precursor geranylgeranyl diphosphate with a double bond shifted from C14=C15 to C15=C16 (named iso‐GGPP III) has been synthesized and enzymatically converted with six bacterial diterpene synthases; this allowed the isolation of nine unnatural diterpenes. For some of the enzyme‐substrate combinations, the different reactivity implemented in the substrate analog iso‐GGPP III opened reaction pathways that are not observed with natural GGPP, resulting in the formation of diterpenes with novel skeletons. A stereoselective deuteration strategy was used to assign the absolute configurations of the isolated diterpenes.
Pain monitoring app leads to less pain in children with cancer at home: Results of a randomized controlled trial
Authors: Simon Julia D. H. P. , Schepers Sasja A. , van Gorp Marloes , Michiels Erna M. C. , Fiocco Marta , Grootenhuis Martha A. , Tissing Wim J. E.
Published: November 2023

Background

The authors developed a pain monitoring app offering educational information, and real‐time health care professional feedback on clinically significant pain (>4 numeric rating scale [NRS]‐11) for children with cancer to reduce pain at home.

Methods

This monocenter, nonblinded randomized controlled trial enrolled Dutch children (0–18 years old) receiving cancer treatment (≥3 months after diagnosis, ≥2 months treatment remaining). Children were randomly assigned to use the app or receive usual care (two parallel groups). We assessed whether use of the app yielded less clinically significant pain (aim 1) and whether it affected pain severity, duration, interference, pain management strategies, and parental emotional well‐being (aim 2). The app was also evaluated by families (aim 3).

Results

A total of 94 children were randomized to use the app (15 drop‐outs), and 90 were to receive care as usual (11 drop‐outs). The app group (n = 79, mean age: 7.5 [5.1] years, 48% girls, 63% hemato‐oncology diagnosis) reported significantly less clinically significant pain compared to usual care (n = 79, mean age: 7.5 [5.4] years, 52% girls, 65% hemato‐oncology diagnosis) (odds ratio [OR], 0.38; 95% confidence interval [CI], 0.198–0.734]) (aim 1), as well as significantly lower pain severity (β = –0.27; 95% CI, –0.407 to –0.142). No differences were found for duration, interference, or management strategies. Parents in the app group reported significantly less distress compared to usual care (β = –0.84; 95% CI, –1.61 to –0.03]) (aim 2). Families generally evaluated the app positively (aim 3).

Conclusions

Use of the app resulted in less clinically significant pain at home. The exact working mechanisms of the app should be further elucidated.
Comparative neuroanatomy of the central nervous system in web‐building and cursorial hunting spiders
Authors: Steinhoff Philip O. M. , Harzsch Steffen , Uhl Gabriele
Published: November 2023

Spiders (Araneae) include cursorial species that stalk their prey and more stationary species that use webs for prey capture. While many cursorial hunting spiders rely on visual cues, web‐building spiders use vibratory cues (mechanosensation) for prey capture. We predicted that the differences in primary sensory input between the species are mirrored by differences in the morphology/architecture of the central nervous system (CNS). Here, we investigated the CNS anatomy of four spider species, two cursorial hunters Pardosa amentata (Lycosidae) and Marpissa muscosa (Salticidae), and two web‐building hunters Argiope bruennichi (Araneidae) and Parasteatoda tepidariorum (Theridiidae). Their CNS was analyzed using Bodian silver impregnations, immunohistochemistry, and microCT analysis. We found that there are major differences between species in the secondary eye pathway of the brain that pertain to first‐order, second‐order, and higher order brain centers (mushroom bodies [MB]). While P. amentata and M. muscosa have prominent visual neuropils and MB, these are much reduced in the two web‐building species. Argiope bruennichi lacks second‐order visual neuropils but has specialized photoreceptors that project into two distinct visual neuropils, and P. tepidariorum lacks MB, suggesting that motion vision might be absent in this species. Interestingly, the differences in the ventral nerve cord are much less pronounced, but the web‐building spiders have proportionally larger leg neuropils than the cursorial spiders. Our findings suggest that the importance of visual information is much reduced in web‐building spiders, compared to cursorial spiders, while processing of mechanosensory information requires the same major circuits in both web‐building and cursorial hunting spiders.