bluuebunny/crossref_metadata_2025 huggingface dataset:
Multisystemic Inflammatory Syndrome Post COVID-19 Infection in an Arab
Female: A Case Report of a Rare Manifestation
Authors: Al Tamakee Areen Yousef , Mohamed Fayad Hesham , Jhancy Malay
Published: April 2023

Background:

Multisystemic inflammatory syndrome is a rare but severe complication in children and adolescents infected with SARS-CoV-2.

Case report:

This report describes a four-year-old Arab descent female presenting with a history of high-grade fever of 7 days duration with erythematous rash
and family history of COVID infection suggestive of atypical Kawasaki disease, which turned out to be multisystemic inflammatory syndrome
(MIS-C) post COVID infection. Based on the available published evidence, the World Health Organization has provided a preliminary definition
of MIS-C as “children and adolescents 0–19 years of age with fever > 3 days presenting with two of five clinical criteria, such as 1. skin rash or
mucocutaneous inflammation or non-purulent conjunctivitis, 2. hypotensive shock, 3. signs of myocardial dysfunction, 4. coagulopathy, and 5. the
acute gastrointestinal problem, elevated inflammatory markers, no evidence of other microbial infections, and evidence of COVID-19 (RT-PCR,
antigen test or serology positive), or likely contact with patients with COVID-19”.

Case Report:

Some criteria are similar, and others are different from Kawasaki disease and toxic shock syndrome, such as the presence of rash, conjunctivitis,
mucocutaneous inflammation, and coronaries involvement are shared criteria between Kawasaki and MIS-C, whereas hypotensive shock and
coagulopathy are shared criteria between MIS-C and toxic shock syndrome. The positive testing for COVID-19 in the absence of microbiological
isolation confirms MIS-C.

Conclusion:

Among the complications of COVID-19 infection, MIS-C is rare. Owing to the management differences among Kawasaki, toxic shock syndrome, and MIS-C, timely diagnosis of MIS-C saves the children from a poor outcome.
Wilms Tumor and Consanguinity: A Case Report
Authors: Patil Jayaditya Devpal , Nassef Sefen Jessica Atef , Raj Pandey Prince , Corbally Martin
Published: April 2023

Introduction:

Wilms tumor, the second most common malignancy in childhood, is associated with hypertension in half the cases, but associated consanguinity rarely comes across, and no direct association between the incidence of nephroblastoma and consanguinity has been noted in current literature.

Case presentation:

We present a rare case of Wilms tumor in a patient with consanguineous parents. The patient is a 4-year-old female that presented with colicky
abdominal pain associated with an abdominal mass, fever over one month and hypertension. There were no congenital anomalies or urinary
symptoms. Both parents are first-degree relatives. The patient underwent surgery, and histopathology confirmed a diagnosis of Wilms tumor. The
postoperative course was uneventful, and chemotherapeutic treatment was initiated.

Conclusion:

The findings in our case highlight a possible causal relationship between Wilms Tumor and consanguinity. There is little published about this, and Wilms's relative risk in consanguineous marriage is unknown. This relationship warrants further research.
An Overview of Recent Advances in Hantzsch’s Multicomponent Synthesis of 1,4-
Dihydropyridines: A Class of Prominent Calcium Channel Blockers
Authors: Saini Keshav Kumar , Rani Rupal , Muskan  , Khanna Neena , Mehta Bhupinder , Kumar Rakesh
Published: April 2023

Among all the heterocyclic scaffolds, 1,4-dihydropyridine (1,4-DHPs) is an important
class of nitrogen-containing heterocyclic compounds possessing prominent therapeutic
effects, which play an essential role in pharmaceutical chemistry. Multicomponent reactions
(MCRs) have proven to be an invaluable tool for swiftly synthesizing large and structurally diverse
molecules from simple starting materials. The chemists have discovered a large number
of new MCRs for the synthesis of 1,4-dihydropyridine. The synthesis of 1,4-Dihydropyridine
via multicomponent reaction is an efficient procedure in terms of delivering adequate structural
diversity, which is essential for the process of discovering new 1,4-DHPs compounds and their
therapeutics.1,4-dihydropyridines are well-known L-type calcium channel blockers. This review
aims to study and summarize the recent developments in the multicomponent synthesis of
1,4-dihydropyridines and their fused analogs that act as potent antihypertensive drugs. The findings of this study
will prove to be an invaluable resource for researchers in the areas of heterocyclic chemistry, medicinal chemistry,
and drug design.
Network Pharmacology and Molecular Docking Reveal the Antioxidant
Potential of Mangiferin from Mango Peel
Authors: Zhang Guangjie , Xue Peiyu , Zhao Hongmei , Guan Tianzhu , Ma Zheng
Published: April 2023

Background:

As one of the main by-products of mango production, the mango peel is rich in
multiple polyphenols, such as mangiferin. Therefore, there is an urgent need to explore the potential
mechanism of mangiferin for nutrition intervention of oxidative stress-related diseases.

Methods:

Mangiferin was extracted and purified from the mango peel and was identified by the reverse
phase high-performance liquid chromatography. The antioxidant potential of mangiferin was determined
in vitro (potassium ferricyanide reducing capacity, DPPH, hydroxyl radicals scavenging ability, and superoxide
anion radicals reducing capacity). In order to explore the potential mechanism for the antioxidant
activity of mangiferin, a combination of network pharmacology and molecular docking approaches
was performed.

Results:

The purity of mangiferin from the mango peel was ≥ 95.0%, and its antioxidant activity was
confirmed by different in vitro assays. ALB, ESR1, CASP8, CASP3, BCL2L1, CXCL8, AKT1, CTNNB,
and EGFR were identified as the potential oxidative stress-related targets of mangiferin. These results
suggested that mangiferin might play a key role in the antioxidant process through multi-targets.

Conclusion:

Integrated with network pharmacology and molecular docking methods, this work demonstrated
the potential mechanism of mangiferin for nutrition intervention of oxidative stress-related diseases.
Gold-catalyzed Reactions of Substituted 1,5-diynes: Recent Advances and
their Chemistry
Authors: Kumar Perla Bharath , Damodar Kongara , Suneel Kanaparthy
Published: April 2023

Diynes are identified as exceptionally potent and superior substrates in gold-catalyzed organic
transformations. Gold (I) and gold (III) complexes exhibit unique activity towards diynes, encouraging
the nucleophilic addition of different functional groups both inter and intra- molecularly. In
this review, particularly, we focused on recent advances in gold-catalyzed reactions of 1,5-diynes
along with their mechanistic aspects. These reactions are interesting for constructing molecular complexity,
medicinal chemistry, and material science.
Functional Modification of Meta-aramid: A Review
Authors: Zhang Zheng , Wang Xiaoyan , Xu Changhai , Jiang Yang , Du Jinmei
Published: April 2023

Meta-aramid is a high-performance polymer based on amide aromatic rings, which has excellent
properties because of its amide bonds and rigid aromaticity. Meta-aramid has been widely used
in the fields of transportation, energy, communication, high-performance protective clothing, military,
and aerospace due to its extraordinary thermal stability, mechanical properties, and chemical structural
stability. Compared to aliphatic polyamides, meta-aramid has higher stiffness and glass transition
temperature. In addition, meta-aramid has poor solubility, and the interfacial compatibility with other
materials needs to be improved. Therefore, meta-aramid is modified by copolymerization and surface
grafting for the purpose of intensifying its functions. The purpose of this review is to discuss the
methods for modification of meta-aramid and the properties of the modified meta-aramids.
Classification of Brain Tumours in MRI Images using a Convolutional Neural
Network
Authors: Gupta Isha , Singh Swati , Gupta Sheifali , Ranjan  Nayak Soumya
Published: April 2023

Introduction:

Recent advances in deep learning have aided the well-being business in Medical Imaging of numerous disorders like brain tumours, a serious
malignancy caused by unregulated and aberrant cell portioning. The most frequent and widely used machine learning algorithm for visual learning
and image identification is CNN.

Methods::

In this article, the convolutional neural network (CNN) technique is used. Augmentation of data and processing of images is used to classify scan
imagery of brain MRI as malignant or benign. The performance of the proposed CNN model is compared with pre-trained models: VGG-16,
ResNet-50, and Inceptionv3 using the technique which is transfer learning.

Results::

Even though the experiment was conducted on a relatively limited dataset, the experimental results reveal that the suggested scratched CNN model
accuracy achieved is 94%, VGG-16 was extremely effective and had a very low complexity rate with an accuracy of 90%, whereas ResNet- 50
reached 86% and Inception v3 obtained 64% accuracy.

Conclusion::

When compared to previous pre-trained models, the suggested model consumes significantly less processing resources and achieves significantly
higher accuracy outcomes and a reduction in losses.
The Possibility of Polygonum cuspidatum against Osteoarthritis based on
Network Pharmacology
Authors: Liu Chengyin , Yu Lingyun , Jiang Yixin , Gu Songlian , Li Chenjian , Yin Wen , Zhou Zhenlei
Published: April 2023

Background:

Polygonum cuspidatum (PC), a widely used Chinese herbal medicine
(CHM), plays an important role in treating various diseases including osteoarthritis (OA). Yet, the
multicomponent and multitarget characteristics of PC make deciphering the pharmacological
mechanisms difficult.

Objective:

The purpose of this study is to identify the core molecular mechanisms of PC against OA.

Methods:

The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used
to search for the active ingredients of PC. GeneCards was then screened to establish relevant databases
for OA. A visual interactive network diagram of the relationship between the active ingredient,
action target, and disease was built using Uniprot. Finally, we used STRING (Search Tool for
the Retrieval of Interacting Genes/Proteins) database to explain the interaction network of proteins
and to further analyze the relationships between related proteins.

Results:

PC was screened for nine potentially effective active compounds that can be used to treat
OA: 6,8-Dihydroxy-7-methoxyxanthone, rhein, physovenine, beta-sitosterol, picralinal, quercetin,
luteolin, catechin, and resveratrol. Using GeneCards database and TCMSP database, we obtained
149 OA-related genes after taking the intersection of OA and PC targets. Moreover, eight core
target proteins were calculated by CytoNCA plugin, which is used for network centrality analysis.
The enrichment analysis of the common target genes shared by PC and OA unraveled the main biological
processes, such as responses to lipopolysaccharide, chemical stress, and reactive oxygen species.
Previous research has demonstrated that signaling pathways related to apoptosis, inflammation,
and cartilage protection are involved with those core target genes we found, like TNF and PI3K-Akt
signaling pathways. The results bring that PC similarly has the potential to treat OA.

Conclusion:

The main purpose of this study is to screen the active ingredients and most important
target molecules of PC in treating OA. This was achieved using bioinformatic tools and databases
to investigate molecular docking technology. The findings provide a theoretical foundation and
potential new treatment plan for OA using PC.
Delayed Wound Healing in the Elderly and a New Therapeutic Target:
CD271
Authors: Zhao Hongqing , Fan Sirui , Sun Jiachen
Published: April 2023

With the development of society, the global population is showing a trend of aging. It is well
known that age is one of the factors affecting wound healing. Aging compromises the normal physiological
process of wound healing, such as the change of skin structure, the decrease of growth factors, the
deceleration of cell proliferation, and the weakening of migration ability, hence delaying wound healing.
At present, research in adult stem cell-related technology and its derived regenerative medicine provides a
novel idea for the treatment of senile wounds. Studies have confirmed that CD271 (P75 neurotropism
receptor/P75NTR)-positive cells (CD271+ cells) are a kind of stem cells with a stronger ability of proliferation,
differentiation, migration and secretion than CD271 negative (CD271- cells). Meanwhile, the total
amount and distribution of CD271 positive cells in different ages of skin are also different, which may be
related to the delayed wound healing of aging skin. Therefore, this article reviews the relationship between
CD271+ cells and senile wounds and discusses a new scheme for the treatment of senile wounds.
Development of Moloney Murine Leukemia Virus Reverse
Transcriptase Fused with Archaeal DNA-binding Protein Sis7a
Authors: Simanjuntak Goldyna M. , Fibriani Azzania , Fananda Amalia A. , Yamahoki Nicholas
Published: April 2023

Introduction:

Moloney Murine Leukemia Virus Reverse Transcriptase (MMLV
RT) is a common enzyme used to convert RNA sequences into cDNA. However, it still has
its shortcomings, especially in terms of processivity and thermostability. According to a
previous patent, the fusion of polymerase enzyme to an archaeal DNA-binding protein has
been proven to enhance its performance. Furthermore, recent studies have also stated that
the fusion of a polymerase enzyme to an archaeal DNA-binding protein is predicted to improve
its thermostability and processivity.

Aim:

As an early stage of enzyme development, this study aimed to design, express, and
purify enzymatically active MMLV RT fused with archaeal DNA-binding protein.

Methods:

RT fusion proteins were designed and evaluated using in silico methods. The RT
fusion enzyme was then expressed in Escherichia coli BL21(DE3) and purified. Its reverse
transcriptional activity was proved using reverse transcription quantitative polymerase
chain reaction (RT-qPCR).

Results:

This study showed that MMLV RT fusion with Sis7a protein at its C-terminal end
using commercial linker (GGVDMI) produced the best in silico evaluation results. The RT
fusion was successfully expressed and purified. It was also known that the optimal condition
for expression of the RT fusion was using 0.5 mM IPTG with post-induction incubation
at room temperature (± 26°C) for 16 hours. In addition, the activity assay proved that
the RT fusion has the reverse transcriptional activity.

Conclusion:

This study shows that the designed MMLV RT Sis7a fusion can be expressed
and purified, is enzymatically active, and has the potential to be developed as an improved
RT enzyme. Further study is still needed to prove its thermostability and processivity, and
further characterize, and plan production scale-up of the MMLV RT Sis7a fusion for commercial
use.
YENİLENMİŞ ANADOLU MESLEK LİSESİ ÖĞRETİM PROGRAMLARININ TEORİ/UYGULAMA DUALİZMİ BAĞLAMINDA DEĞERLENDİRİLMESİ
Authors: Özkan Umut Birkan
Published: April 2023

Anadolu Meslek Lisesi öğretim programları, 2020 yılında 47 alandaki 109 dalda güncellenerek uygulamaya koyulmuştur. Bu araştırma, Anadolu Meslek Liselerinde kullanılan programlardan dört farklı alan/dalın öğretim programlarını teori/uygulama düalizmi bağlamında değerlendirmeyi amaçlamaktadır. Araştırmada nitel araştırma yöntemlerinden biri olan doküman analizi yöntemi kullanılmıştır. Olasılık temelli örnekleme yöntemlerinden küme örnekleme ve seçkisiz örnekleme yöntemlerinin birlikte kullanıldığı bu çalışmanın örneklemini Elektrikli Cihazlar Teknik Servisi Dalı, Mimari Yapı Teknik Ressamlığı Dalı, Terzilik Dalı ve Yenilenebilir Enerji Teknolojileri Dalı öğretim programları oluşturmaktadır. Veriler betimsel analiz yöntemiyle analiz edilmiştir. Çalışma kapsamında yer alan branşların 9., 10. ve 11. sınıflarında yer alan zorunlu meslek derslerinin kazanımlarına ilişkin bulgular, teori/pratik düalizminde pratiğe ağırlık verildiğini açıkça ortaya koymaktadır. Öğretim programlarında yer alan kazanımlar taksonomik olarak sınıflandırıldığında devinişsel alandaki kazanımların ağırlıkta olduğu ve buna paralel olarak öğrenenlerde uygulamaya yönelik talepler oluşturmayı hedeflediği sonucuna ulaşılmıştır. Bununla birlikte, uygulama yoluyla öğrenmeye odaklanmak, teorik bilgiyi dışlamayı gerektirmediği gibi pek çok meslekte ve iş türünde teori ve uygulama o kadar iç içedir ki, Anadolu Meslek Lisesi programları için teori ile pratiği ayırmak pek mantıklı gelmeyebilir. Anadolu Meslek Liseleri için gelecekte yapılacak olan öğretim programı geliştirme çalışmalarına yönelik öneriler sunulmuştur.
Studies on Variability of Physico-Biochemical Parameters of Mango Fruit
Authors: KK PATEL , KAR1 ABHIJIT
Published: April 2023

More than a thousand varieties of mango (Mangifera indica L.) are grown in India. Their quality attributes not only differed altogether but also depends on their maturity and storage after harvest. An experiment on four mango varieties harvested at pre-, optimum, and over-maturity stages from different orchards was conducted in this study. The effect of varieties and harvest stage, and their interactions on external diameters, arithmetic and geometric mean diameters, sphericity, and aspect ratio was analyzed. Similarly, the change in peel color values, specific gravity, total soluble solids, titratable acidity, and total carotenoids with respect to varieties, harvest stage, and storage periods and their interactions were analyzed statistically. Dimensions, size, weight, volume, aspect ratio, and sphericity varied significantly among the cultivars and were found to be increased significantly from the pre-to-over maturity stage.  Interaction between the harvest stage and cultivars also had a significant (p<0.05) effect on the fruit’s breadth, thickness, size, weight, volume, aspect ratio, and sphericity (except on length). Similarly, specific gravity and peel color values and biochemical attributes were also found to be changed significantly among the cultivars, maturity stages, and storage periods. The effect of their interactions on peel color values and bio-chemical properties was also significant. However, there is an insignificant effect of interactions on the specific gravity of mangoes. Results concluded that most of the physical and biochemical parameters of mangoes were variable and dependent on cultivar type, maturity stage and storage period, and on their interactions. This study, therefore, can be fruitful during the designing of processing equipment and can be helpful in the post-harvest management of mangoes
A Digital-First Health Care Approach to Managing Pandemics: Scoping Review of Pandemic Self-triage Tools
Authors: Ziebart Christina , Kfrerer Marisa L , Stanley Meagan , Austin Laurel C
Published: April 2023

Background

During the COVID-19 pandemic, many patient-facing digital self-triage tools were designed and deployed to alleviate the demand for pandemic virus triage in hospitals and physicians’ offices by providing a way for people to self-assess their health status and get advice on whether to seek care. These tools, provided via websites, apps, or patient portals, allow people to answer questions, for example, about symptoms and contact history, and receive guidance on appropriate care, which might be self-care.

Objective

This scoping review aimed to explore the state of literature on digital self-triage tools that direct or advise care for adults during a pandemic and to explore what has been learned about the intended purpose, use, and quality of guidance; tool usability; impact on providers; and ability to forecast health outcomes or care demand.

Methods

A literature search was conducted in July 2021 using MEDLINE, Embase, Scopus, PsycINFO, CINAHL, and Cochrane databases. A total of 1311 titles and abstracts were screened by 2 researchers using Covidence, and of these, 83 (6.76%) articles were reviewed via full-text screening. In total, 22 articles met the inclusion criteria; they allowed adults to self-assess for pandemic virus, and the adults were directed to care. Using Microsoft Excel, we extracted and charted the following data: authors, publication year and country, country the tool was used in, whether the tool was integrated into a health care system, number of users, research question and purpose, direction of care provided, and key findings.

Results

All but 2 studies reported on tools developed since early 2020 during the COVID-19 pandemic. Studies reported on tools that were developed in 17 countries. The direction of care advice included directing to an emergency room, seeking urgent care, contacting or seeing a physician, being tested, or staying at home and self-isolating. Only 2 studies evaluated tool usability. No study demonstrated that the tools reduce demand on the health care system, although at least one study suggested that data can predict demand for care and that data allow monitoring public health.

Conclusions

Although self-triage tools developed and used around the world have similarities in directing to care (emergency room, physician, and self-care), they differ in important ways. Some collect data to predict health care demand. Some are intended for use when concerned about health status; others are intended to be used repeatedly by users to monitor public health. The quality of triage may vary. The high use of such tools during the COVID-19 pandemic suggests that research is needed to assess and ensure the quality of advice given by self-triage tools and to assess intended or unintended consequences on public health and health care systems.
Patient education for all? Skin of colour under-represented again. (Preprint)
Authors: Long Amy Kathleen , Long Alison Teresa , Murphy Lisa Christine
Published: April 2023

UNSTRUCTURED

We examined the representation of people with skin of colour in patient information resources from multiple dermatological bodies around the world. We found a stark under-representation of skin of colour, which can lead to deleterious consequence on health outcomes. Dermatological communities must join the global effort to eliminate racial disparities, to improve approachability, inclusiveness and trust within our specialty.
Estimation of Water Carrying Capacity for Floating Net Cage Cultivation Activities in Pekalongan Coastal Waters
Authors: Mardiana Tri Yusufi , Ariadi Heri , Linayati Linayati , Wijianto Wijianto , Fahrurrozi Ashari , Maghfiroh Maghfiroh
Published: April 2023

Floating cage fish farming is an aquaculture activity that is mostly carried out on the coast of Pekalongan. The purpose of this study was to estimate the carrying capacity of Pekalongan coastal waters as a floating net cage aquaculture activity zone. The research method used is descriptive qualitative and quantitative descriptive by calculating the indicators of Trophic Status Index (TSI), phosphorus, feed conversion ratio, and the carrying capacity level of the waters. The results showed that chlorophyll-a values ranged from 6.44-8.24 ꭒg/L, total phosphorus 12.44-14.80 ꭒg/L, feed conversion ratio 1.10-1.25, TSI (Trophic Status Index) values 48.2-54.6, harvested biomass 120-157 kg/ floating net cages (KJA). The carrying capacity of the waters for KJA cultivation is 145.43 tons of fish/year, and the number of existing KJA for cultivation is 110 KJA. The conclusion from the results of this study is that the carrying capacity on Pekalongan coastal waters when used as a floating net cage aquaculture activity zone is estimated to be able to accommodate approximately 145.43 tons of fish/year or the equivalent of 121 KJA. Currently, there are 110 KJA plots in the Jeruksari coastal waters, which means that the maximum carrying capacity of the waters that can be used for KJA cultivation is 11 KJA.
Enhancing Fishing Port Services Quality to Support Fish Supply Chains of the Island Fisheries at the Belitung Island
Authors: Nur Farisha Safrina , Suadi Suadi , Suwarman Suwarman
Published: April 2023

Fishing ports are crucial to the sustainable management of fisheries resources and enterprises that depend on the fishery. The objective of this study was to analyze the levels of facilities availability and service quality of fishing ports in the islands through a case study of Tanjungpandan Islands Fishing Port in Belitung Island. This study was conducted by combining survey methods, observation, as well as in-depth interviews with the port users and managers.  Due to Covid-19 pandemic, field research was conducted in two periods: from September to October 2020 and from January to February 2022. Respondents were selected by applying the snowball sampling method and resulted in 70 selected respondents, consisting of fishermen, skippers, traders, factory managers or fish processing units, and port managers. Structured questionnaires were used for data collection.  It proceeded into descriptive-qualitative analysis and combined with SERVQUAL and IPA (Importance Performance Analysis) methods. The study demonstrated that six port facilities failed to meet the Nusantara (inter-island) fishing port standards as outlined in the Minister of Marine Affairs and Fisheries' Regulation No. 8, year 2012. Eight port services that were considered important indicated low performance to support the island’s fish supply chain. The total score of basic, functional, and supporting facilities was 60.46% (within 0 – 100% scale) and considered as relative “good”. Therefore, given that the port is the main hub of marine fisheries activities on Belitung island, it is crucial to increase the accessibility, quality, and services of fishing port facilities in order to support the fish supply chain in the islands.
Regular Open Sets on The Intuitionistic Fuzzy Topological Spaces in Sostak's Sense
Authors: Menagadevi T. , Maragatha Meenakshi P. , Rajesh Neelamegarajan
Published: April 2023

The aim of this paper is to introduce and study the concepts of intuitionistic r-fuzzy regular open sets and their related notions in topological spaces.
Quasicontinuous Function on Strong Forms of Connected Space
Authors: Bishnoi Chander Mohan , Mishra Sanjay
Published: April 2023

Preservation of properties under continuous functions on topological spaces is a very important tool for the classification of topological spaces. However, in some cases the quaiscontinuous functions are more useful than the continuous functions for classifying topological spaces. In this paper, we study preservation of strong forms of connectedness under quasicontinuous function that help to prove the general form of intermediate value theorem.
Influence of Georgian Saperavi Grapevine Shoots Extract on Lipid Profile in Diet-Induced Hypercholesterolemia in Rats
Authors: Bokuchava Natia , Murtazashvili Tamaz , Mitagvaria Nodar , Sivsivadze Koba , Tatanashvili Mariam
Published: April 2023

Hypercholesterolemia raises the risk of cardiovascular diseases (CVD), the leading cause of morbidity and mortality worldwide. Numerous clinical trials of lipid-lowering diets and medicines have been established for proper lipid profile regulation to reduce the significant level of pathological conditions of cardiovascular origin. Winemaking is a well-developed part of Georgian agriculture. Besides usual products such as grapes and wine, it is characterized by a significant amount of waste products like leaves and shoots, which can be used as a source of bio-active ingredients, namely polyphenols, which are wellknown to have hypocholesterolemia effects. Therefore, the decision was made to use polyphenols derived from wasted shoots and assess their potential protective and treating effect on lipid profile in the Vivo model of dietary-induced hyperlipidemia. During previous studies, 14 individual polyphenols were extracted and detected from Georgian grapevine shoots, and current research demonstrates the cholesterol-lowering effects of this polyphenol-rich extract in laboratory rats. Study results demonstrated the positive protective effect of Georgian Vitis Vinifera (Saperavi) polyphenols on the lipid profile of rats. Along with relatively low values of total cholesterol (5.47%), LDL (16%), and TG (9.9%), better results for HDL value were observed for the group receiving Saperavi shoots extract, than the group receiving only a hypercholesterolemia diet. Compared with a 10 mg/kg Atorvastatin daily dose, Saperavi shoots extract showed a smoother reduction of serum cholesterol; however, the normal range was reached. These findings support the potential of using currently wasted Georgian grapevine shoots as a source of biologically active ingredients. Based on the study results, Saperavi shoot extract can be considered a cost-effective candidate for phytomedicine supplementing and treating cardiovascular diseases associated with lipid profile disorders.
PROBLEMS OF CONFORMITY AND JUDICIALS OF CIVIL AND ADMINISTRATIVE CASES WITH PARTICIPATION OF MOBILIZED PERSONS
Authors:   Институт государства и права Российской академии наук, Москва, Россия, Мариетта Дамировна Шапсугова
Published: April 2023

With the publication of Decree of the President of the Russian Federation of September 21, 2022 N 647 «On the announcement of partial mobilization in the Russian Federation», a range of practical issues arose related to the determination of jurisdiction and arbitrability of disputes involving mobilized persons. These problems arise from legal uncertainty regarding certain aspects of the legal status of a mobilized person. Thus, in order to determine jurisdiction and jurisdiction, it is necessary to clarify not only the subject and nature of the dispute, but also the moment when the status of a military man arises for a mobilized person. The range of issues that are covered by the intersectoral status of a mobilized person as a citizen, a military man, predetermines the jurisdiction and jurisdiction of disputes with his participa-tion both to arbitration courts and courts of general jurisdiction, including military courts in the framework of arbitration, civil, administrative, criminal proceedings. A separate analysis is required by the provisions of the federal law of December 29, 2022 N 603-FZ «On Amendments to Certain Legislative Acts of the Russian Federation» on the suspension of proceedings in a case involving a mobilized person.
TO THE QUESTION OF THE RELATIONSHIP BETWEEN THE CONCEPTS OF «JURISDICTION», «COGNIZANCE» AND «COMPETENCE»
Authors:   Саратовская государственная юридическая академия, Саратов, Россия, Мария Юрьевна Петрова
Published: April 2023

The article analyzes the concepts of «jurisdiction», «cognizance» and «competence» on the basis of their relationship with each other, in connection with the amendments made to the regulatory legal acts. In points to different procedural consolidation and different understanding of these concepts in the texts of the law, which, according to the author, is unacceptable, and therefore, it is proposed to introduce appropriate changes to the current legislation.
BOOK REVIEW: SERKOV P. P. LEGAL RELATIONSHIP (THEORY AND PRACTICE OF MODERN LEGAL POLICY): MONOGRAPH: IN TWO PARTS. M.: NORMA, 2023. PART I – 872 P., PART II – 672 P.
Authors:   Верховный Суд Республики Ингушетия, Магас, Россия, Ибрагим Аюбович Фаргиев
Published: April 2023

The ideas of Professor P. P. Serkov on the problem of legal relations are considered through the prism of the theory and practice of today's legal policy. This issue was analyzed by him comprehensively, taking into account the information accumulated by representatives of various sciences. The book under review includes an interweaving of historical, psychological, sociological, anthropological, legal ideas, statistical data and attitudes to legal relations in the scientific literature, as well as an analysis of legislation. The author's approach to the study to the study of the mechanism of legal relations and political and legal processes in a broad context using the achievements of social and natural sciences is evaluated. Fundamental research can be the beginning of a new stage of reflection on legal policy, it can become an incentive for further research in the field of legal relations theory.
METAVERSE AS A FACTOR OF TRANSFORMATION OF LEGAL REGULATION
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Святослав Петрович Федоренко ,   Ростовский юридический институт МВД России, Ростов-на-Дону, Россия
Published: April 2023

The article discusses modern digital technologies that affect the main spheres of life of the state and society. Special attention is paid to the processes of metaverse formation. The problems of legal regulation of public relations in the meta-industry in the context of the functioning of key legal institutions are analyzed. The current trends in the development of digital technologies and their impact on state control and legal regulation are indicated. The problem of the transborder nature of the metaverse in the context of the jurisdiction of states is considered. The experience of advanced states in this process is shown through the use of ethics and legal norms in the virtual space. The main problems of legal regulation of the metaverse are analyzed and measures are proposed to minimize threats, risks and challenges associated with the digitalization of public relations.
THE RIGHT TO HEALTH AND HEALTH CARE: CONSTITUTIONAL BASIS OF LEGAL REGULATION IN FOREIGN COUNTRIES
Authors:   Московский экономический институт, Москва, Россия, Ирина Владимировна Симкина
Published: April 2023

The article is devoted to research on the constitutional basis of legal regulation of the right to health and health care in foreign countries of Europe, Asia, South and North America based on the analysis of the constitutions of foreign states has been conducted. The Russian doctrine and foreign experience regarding the methodology and content of the relevant legal impact in the field of healthcare are included. Subjective competencies in the field of health care are investigated, the same standards that have received constitutional recognition in most foreign countries are identified.
LEGAL REGULATION OF NON-PROPERTY RELATIONS OF SPOUSES IN THE FAMILY
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Ольга Григорьевна Зубарева
Published: April 2023

The article analyzes the uniqueness of the institution of the family and the reasons for its destruction. A number of patterns are indicated that allow us to talk about the historical mission of the family. It is concluded that it is necessary to reform certain provisions of the Family Code and, taking into account the priorities of the state family policy, to reassess existing ideas about the possibility of legal regulation of non-property relations of spouses in the family. Despite the "revolutionary" nature of some proposals, the article aims to invite discussion.
CRITERIA OF GOOD FAITH WHEN RESOLVING THE ISSUE OF PRE-CONTRACTUAL LIABILITY IN CIVIL LAW
Authors:   Санкт-Петербургский государственный архитектурно-строительный университет, Санкт-Петербург, Россия, Анна Андреевна Кружевникова
Published: April 2023

The article deals with the theoretical and practical aspects of the institution of pre-contractual liability in civil law. In particular, the variety of interpretations of the concept of "good faith" and the problems associated with the lack of a common denominator regarding the allocation of its special properties are investigated; signs of dishonest behavior are indicated, such as the provision of incomplete or inaccurate information to a party and the sudden termination of negotiations by one of the parties, provided that the other party could not have expected this to happen. The problems of creating a comfortable "contractual environment" were also investigated and judicial practice on the stated issues was studied.
Synthesis and Characterization of Rod-Bent Shape Compounds Containing Bis-Oxadiazole
Authors:   Ministry of Education, Directorate of Education Al-Muthanna, Al-Samawah, Al-Muthanna, Iraq, M. Rasol Aqeel , R. Jber Nasreen ,   Department of Chemistry, College of Science, Al-Nahrain University, Jadriya, Baghdad, Iraq
Published: April 2023

In this work, two new mesomorphic bent-rod shape compounds containing bis-oxadiazole rings are described. The relationship between the compound structure and the mesomorphic behavior as 3,3'-benzene-1,4-diylbis[5-(4-nitrophenyl)-1,2,4-oxadiazole] and 3,3'-benzene-1,4-diylbis[5-(4-chlorophenyl)-1,2,4-oxadiazole] were established using different terminal groups (i.e.,NO2, Cl). The mesomorphism was categorized using POM and DSC, while the compounds structure were characterized using FT-IR and 1HNMR.
Study of Drugs: Antibiotic and Study Mechanism and Adverse Effects
Authors:   Forensic DNA Research and Training Center, Al-Nahrain University, Jadriya, Baghdad, Iraq, K.Hussein Haider , A.Abdel Jabbar Ban ,   Forensic DNA Research and Training Center, Al-Nahrain University, Jadriya, Baghdad, Iraq, S. Amin Seenaa ,   Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad, Iraq, A. Jawad Asmaa ,   Forensic DNA Research and Training Center, Al-Nahrain University, Jadriya, Baghdad, Iraq, K. Abbas Ruqaya ,   Ministry of Health, Central Children Hospital, Baghdad, Iraq, A. Jawad Shaymaa ,   Ministry of Health, Alshahid Mohammad Bagir Al-Hakeem Hospital. Baghdad. Iraq
Published: April 2023

A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Antibiotics are medicines that fight bacterial infections in people and animals. They work by killing the bacteria or by making it hard for the bacteria to grow and multiply. The antibiotic can class according to structure or action or basic. Every drug have side effects on body if use If taken incorrectly.
Approximate Solution of Linear Interval Fuzzy Ordinary Differential Equations
Authors:   Department of Mathematics and Computer Applications, College of Science, Al-Nahrain University, Jadriya, Baghdad, Iraq, M. Rasheed Sohaib , S. Fadhel Fadhel ,   Department of Mathematics and Computer Applications, College of Science, Al-Nahrain University, Jadriya, Baghdad, Iraq
Published: April 2023

Approximate solution of fuzzy initial value problem composed of interval fuzzy ordinary differential equation subject to initial conditions given as fuzzy intervals is the main objective of this work. The considered fuzzy initial value problem was given with Hukuhara definition of the difference and derivatives for interval-valued functions, in which two cases are considered depending on the comparison between the lower and upper functions of the solution derivative. The followed definition for presenting the fuzzy interval is generalized using trapezoidal fuzzy number, while the followed approximated method used in this work is the variational iteration method and its modification to increase the accuracy and the rate of convergence to the exact solution.
Fielding and Marivaux (on the Genealogy of the English Rococo Novel)
Authors:   Lomonosov Moscow State University, Pakhsarian Natalia T. ,   Institute of Scientific Information for Social Sciences of the Russian Academy of Sciences
Published: April 2023

The article specifies the course of evolution of the English novel in the 17th and 18th centuries and compares it to the development of the French novelistic prose of the same period. The semantics of the Enlightenment terms “romance” and “novel” is spelled out, as well as the part Introductions played in making the novela self-conscious genre. Fielding’s critical stance, informing both his plays and novels, prompts appearance of elements of Rococo poetics in his early writings, which are very similar to those employed by Marivaux, a recognized Rococo author. The ironic games, the urge to amuse the reader, certain particularities of comism, keeping the burlesque at bay, the habit to represent action in interior spaces, the remarkable engagement with the Cervantes tradition — all of this distinguishes both Fielding’s Joseph Andrews and Marivaux’s Pharsamon, as well as other early writings of the French author. The offered analysis allows readers to rethink the accustomed evaluation of Fielding’s novels as realistic and pay closer attention to the Rococo matter in English prose of the 18th century.
The Problem of Authorial Presence in a “Textual Frame” (Richardson’s Pamela and Fielding’s Shamela)
Authors:   Oles Honchar Dnipro National University, Vatchenko Svetlana A.
Published: April 2023

The article highlights one of the episodes of English literary life in 1740s when Samuel Richardson, a printer, in his 50s, who turned into a novelist and — after having acquainted the readers with the story of a maidservant who rose to the rank of a lady — witnessed both the resounding success and harsh criticism. First published anonymously, his Pamela; or, Virtue Rewarded was imitated, “rewritten” and unmercifully criticized. Comic reworking of the sensational story of the heroine titled by unknown author as An Apology for the Life of Mrs. Shamela Andrews was considered by Londoners unexpectedly fresh and funny. Its extensive title promised to the public the scandalous unmasking of the deceiver known under the name of Pamela. In circumstances that became crucial for their literary biographies, Richardson and Fielding in Pamela and Shamela, which, through parody, became a live and playful whole, have proposed various modes of “frame ensemble” by their texts. While readers’ emotional delicacy, exalted feeling and belief in virtuous rebirth of the hero ensured access to the artistic universe of Pamela, Fielding’s readers had to meet different requirements: thorough understanding of Shamela comes to those with intellectual breadth and flexible minds, who in many ways seem to be the author’s equal and are sure that the true virtue does not clash with earthly happiness.
The Wholeness of Scenic Image in Fielding’s The Tragedy of Tragedies
Authors:   Maksim Gorky Institute of Literature and Creative Writing, Mozhaeva Anita B.
Published: April 2023

The essay probes into particularities of Fielding’s play “Tom Thumb and The Tragedy of Tragedies”, his parody of Restoration tragedy; the latter was very popular with the theatregoers of the time. The essay shows how the heterogeneous stylistic elements of the play get united into a complete whole. Fielding seemed to believe that in order to truthfully capture a reality within a creative work, one has not to go against artistic conventionality, but to lean on it. There was just one problem left: to keep up this dynamic balance he achieved.
Determinants of digital financial literacy from students’ perspective
Authors: Adnan Mohd Fairuz , Rahim Nurhazrina Mat , Ali Norli
Published: April 2023

In Malaysia, there has been an increase in bankruptcy cases among the younger generation, indicating poor money management among youths. The Coronavirus Disease 2019 (COVID–19) outbreak has exacerbated this emerging financial issue since financial transactions are now more accessible through the growth of online digital financial products and services (DFS) (Mansour, 2022). Therefore, it is crucial that the younger generation is financially literate from the digital perspective — digital financial literacy (DFL). This study identified factors that may affect one’s DFL that have not been previously explored in the financial literacy literature. In a survey that involved 183 Malaysian university students, determinants of DFL were identified, namely: financial knowledge score (FKS), programme or study level (PL), gender, age, as well as parental influence (PRI), peer influence (PEI), and social media influence (SMI). The data were analysed using partial least squares (PLS) modelling. The structural model analysis revealed that FKS and SMI positively impacted DFL, highlighting the importance of social media for financial education. Age had an insignificantly negative effect on DFL, contradicting earlier studies that used age as a proxy for financial experience. This research outcome adds to the existing and growing literature on DFL, which has lately gained prominence due to the proliferation of DFS.
Treatment of palmoplantar psoriasis with monochromatic excimer light (308-nm) versus cream PUVA
Authors: Neumann NJ , Mahnke N , Korpusik D , Stege H , Ruzicka T.
Published: April 2023

Palmoplantar psoriasis is a chronic disease, which is very resistant to treatment and often leads to severe disabilities. Photochemotherapy employing psoralens combined with UVA irradiation (PUVA) is a well-accepted therapy for palmoplantar psoriasis. Its topical application (bath PUVA; cream PUVA) avoids the typical side effects of orally applied psoralens. We compared the efficacy of cream PUVA therapy with monochromatic excimer light therapy, a treatment modality employing 308-nm UVB radiation generated by a new kind of light source. Ten patients with psoriasis of the palms and soles were randomly assigned to receive cream PUVA on one side and 308-nm UVB on the contralateral side. Based on the psoriasis area and severity index (PASI) score, clinical assessment was carried out before and 5 weeks after the beginning of the study. At the end of the treatment period both test groups showed a remarkable PASI score reduction (308-nm UVB, 63.57%; cream PUVA, 64.64%). No relevant adverse effects were observed, except for mild irritation in a few patients. After a 12-week follow-up, a relapse of the disease was only observed in one patient. Thus, mono-chromatic excimer light cleared palmoplantar psoriasis as rapidly as cream PUVA. In contrast to cream PUVA, monochromatic excimer light therapy is not associated with prior drug application. This might lead to a lower incidence of adverse reactions and better compliance. Therefore, monochromatic excimer light therapy seems to be a useful new therapeutic option for palmoplantar psoriasis.
Rowell Syndrome with Palmoplantar Involvement and Suspected Epitope Spreading
Authors: Marini Alessandra , Draeger Heike , Schneider Matthias , Niedermeier Andrea , Hertl Michael , Ruzicka Thomas , Hengge Ulrich R.
Published: April 2023

This article does not have an abstract.
Chronic Urticaria and Mild Arthritis Associated with Autoimmune Thyroid Disease: Successful Treatment with L-Thyroxine
Authors: Milchert Marcin , Flici?ski Jacek , Ostanek Lidia , Brzosko Marek
Published: April 2023

This article does not have an abstract.
Long-term Follow-up of Photodynamic Therapy for Mycosis Fungoides
Authors: Wiegleb Edström Desiree , Hedblad Mari-Anne
Published: April 2023

This article does not have an abstract.
Eosinophilic Fasciitis and Combined UVA1 – Retinoid – Corticosteroid Treatment: Two Case Reports
Authors: Weber Hans O. , Schaller Martin , Metzler Gisela , Röcken Martin , Berneburg Mark
Published: April 2023

This article does not have an abstract.
Cutaneous Necrosis Induced by Extravasation of Arginine Monohydrochloride
Authors: Amano Hiroo , Nagai Yayoi , Kowase Takanori , Ishikawa Osamu
Published: April 2023

This article does not have an abstract.
Anaplastic Large Cell Lymphoma Associated with Parapsoriasis en Plaques
Authors: Sugaya Makoto , Murai Takaya , Tamaki Kunihiko
Published: April 2023

This article does not have an abstract.