bluuebunny/crossref_metadata_2025 huggingface dataset:
Subcritical transitional flow in two-dimensional plane Poiseuille flow
Authors: Huang Z. , Gao R. , Gao Y.Y. , Xi G.
Published: September 2024

Recently, subcritical transition to turbulence in the quasi-two-dimensional (quasi-2-D) shear flow with strong linear friction (Camobreco et al., J. Fluid Mech., vol. 963, 2023, R2) has been demonstrated by the 2-D mechanism at

$Re = 71\,211$

, and the nonlinear Tollmien–Schlichting (TS) waves related to the edge state were approached independently of initial optimal disturbances. For 2-D plane Poiseuille flow, transition to the fully developed turbulence requires that the Reynolds number is several times larger than the critical Reynolds number

$Re_c$

(Markeviciute & Kerswell, J. Fluid Mech., vol. 917, 2021, A57). In this paper, we observed the subcritical transitional flow in 2-D plane Poiseuille flow driven by the nonlinear TS waves by both linear and nonlinear optimal disturbances (

$Re < Re_c$

) with different quantitative edge states. The nonlinear optimal disturbances could trigger the sustained subcritical transitional flow for

$Re \geqslant 2400$

. The initial energy for nonlinear optimal disturbance is more efficient than the linear optimal disturbance in reaching the subcritical transitional flow for

$2400 \leqslant Re \leqslant 5000$

. Moreover, the initial energy of linear optimal disturbance is larger than the energy of its edge state. The nonlinear TS waves along the edge state are formed by the nonlinear optimal disturbances to trigger transitional flow, which agrees well with the main conclusions of Camobreco et al. (J. Fluid Mech., vol. 963, 2023, R2), while the required

$Re$

of 2-D plane Poiseuille flow is much smaller.
Influence of outer large-scale motions on near-wall structures in compressible turbulent channel flows
Authors: Zhou Zisong , Wang Yixiao , Zhang Shuohan , Huang Wei-Xi , Xu Chun-Xiao
Published: September 2024

The influence of outer large-scale motions (LSMs) on near-wall structures in compressible turbulent channel flows is investigated. To separate the compressibility effects, velocity fluctuations are decomposed into solenoidal and dilatational components using the Helmholtz decomposition method. Solenoidal velocity fluctuations manifest as near-wall streaks and outer large-scale structures. The spanwise drifting of near-wall solenoidal streaks is found to be driven by the outer LSMs, while LSMs have a trivial influence on the spanwise density of solenoidal streaks, consistent with the outer LSM impacts found in incompressible flows (Zhou et al., J. Fluid Mech., vol. 940, 2022, p. A23). Dilatational motions are characterized by the near-wall small-scale travelling-wave packets and the large-scale parts in the outer region. The streamwise advection velocity of the near-wall structures remains at

$16 \sim 18u_{\tau }$

, hardly influenced by Mach numbers, Reynolds numbers and wall temperatures. The spanwise drifting of near-wall dilatational structures, quantified by the particle image velocimetry method, follows a mechanism distinct from solenoidal streaks. This drifting velocity is notably larger than those of the solenoidal streaks, and the influence of outer LSMs is not the primary trigger for this drifting.
Applying a person-oriented approach to workplace aggression: Implications for employee emotional well-being
Authors: Gururaj Hamsa , Schat Aaron C. H.
Published: September 2024

Using a person-oriented approach with a broad sample of 200 employees across several sectors, we identified four victim subgroups sharing similar configurations of frequency and severity of aggression: high–high (high levels of frequency and severity; 15%), moderate–moderate (moderate levels of frequency and severity; 15%), high–low (high frequency but low severity; 26.5%), and low–low (lowest levels of frequency and severity; 43%). Further, we examined the relationship between victim groups, social demographics, and victim disposition. The results showed that women, young, and lower-tenured employees are at risk of belonging to the high–high victim group. In addition, employees with high negative affect and psychopathy traits are at risk of belonging to the high–high victim group. Drawing upon learned helplessness theory, we examined whether victim groups differed concerning internalizing problems. Results suggest that high–high group victims experienced the highest anxiety, loss of confidence, and social dysfunction, whereas low–low group members experienced the lowest levels.
Supporting Co-Regulation and Development of Self-Regulation Skills in Students With Intellectual Disabilities: A Scoping Review
Authors: Andrikos Gillian P. , Smith Cindy Ann , Ciccarelli Marina
Published: September 2024

Young people with intellectual disability (ID) frequently have challenges with self-regulation that impact their success and participation in daily life. As they often require additional support with self-regulation, it is important to consider regulatory function and skill development within the context of co-regulatory interactions with caregivers. This scoping review aimed to identify factors associated with improved self-regulation and co-regulation in young people with ID. The review was conducted using Arksey and O’Malley’s (2005) framework, with 142 full-text records reviewed and critically appraised. The diverse factors that affect regulatory function in young people with ID fit within the five categories identified in the model of factors contributing to self-regulation enactment — biology, skills, motivation, caregiver support, and environmental context — highlighting the relevance of this model to regulatory function for this population. This review’s findings allow this model to be refined further for young people with ID, identifying the unique factors contributing to self-regulation enactment for this population and intervention characteristics that may support regulatory function for these individuals.
Multimodal training on L2 Japanese pitch accent: learning outcomes, neural correlates and subjective assessments
Authors: Hirata Yukari , Friedman Erica , Kaicher Caroline , Kelly Spencer D.
Published: September 2024

Japanese pitch accent is phonemic, making it crucial for second-language learners to acquire. Building on theories of multimodal learning, the present study explored how auditory, visual and gestural training of Japanese pitch accent affected behavioral, neural and meta-cognitive aspects of pitch perception across two experiments. Experiment 1 used a between-subjects pre/posttest design to train native English speakers to perceive Japanese pitch accents in one of the following three conditions: (1) baseline (audio + flat notation), (2) pitch height notation (audio + notation mimicking pitch height) and (3) pitch height notation + a left-hand gesture (L-gesture) (to engage the contralateral right hemisphere specialized for suprasegmental pitch processing). Our results indicated that (2) pitch height notation training was most robust in its benefits, as participants in this condition improved on trained and novel words alike. Experiment 2 used a within-subjects design to extend Experiment 1 in three ways: adding a right-hand gesture (R-gesture) condition (to engage more segmental language areas in the left hemisphere), introducing a neural correlate of cognitive load (measured by EEG alpha and theta power) and performing a metacognitive subjective assessment of learning (e.g., ‘Which training did you find the most helpful?’). The results showed that although there were no differences among our four training conditions on learning outcomes or EEG power, participants made the most positive subjective evaluations about pitch height notation and R-gesture training. Together, the results suggest that there may be a ‘just right’ amount of multimodal instruction to boost learning and increase engagement during foreign language pitch instruction.
Vitamin D, periodontitis and tooth loss in older Irish adults
Authors: Winning Lewis , Scarlett Siobhan , Crowe Michael , O’Sullivan Michael , Kenny Rose Anne , O’Connell Brian
Published: September 2024

The aim of this study is to investigate whether 25-hydroxyvitamin D (25(OH)D) is associated with periodontitis and tooth loss in older adults. A total of 2346 adults underwent a detailed dental examination as part of the health assessment of a national population study – The Irish Longitudinal Study of Ageing. 25(OH)D analysis was performed on frozen non-fasting total plasma using LC-MS. The analysis included both multiple logistic regression and multinominal logistic regression to investigate associations between 25(OH)D concentration, periodontitis and tooth loss, adjusting for a range of potential confounders. Results of the analysis found the mean age of participants was 65·3 years (sd 8·2) and 55·3 % of the group were female. Based on the quintile of 25(OH)D concentration, participants in the lowest v. highest quintile had an OR of 1·57 (95 % CI 1·16, 2·13; P < 0·01) of having periodontitis in the fully adjusted model. For tooth loss, participants in the lowest v. highest quintile of 25(OH)D had a RRR of 1·55 (95 % CI 1·12, 2·13; P < 0·01) to have 1–19 teeth and a RRR of 1·96 (95 % CI 1·20, 3·21; P < 0·01) to be edentulous, relative to those with ≥ 20 teeth in the fully adjusted models. These findings demonstrate that in this cross-sectional study of older men and women from Ireland, 25(OH)D concentration was associated with both periodontitis and tooth loss, independent of other risk factors.
Associations between dietary fatty acid and plasma fatty acid composition in non-alcoholic fatty liver disease: secondary analysis from a randomised trial with a hypoenergetic low-carbohydrate high-fat and intermittent fasting diet
Authors: Tillander Veronika , Holmer Magnus , Hagström Hannes , Petersson Sven , Brismar Torkel B. , Stål Per , Lindqvist Catarina
Published: September 2024

Dietary fatty acids (FA) affect metabolic risk factors. The aim of this study was to explore if changes in dietary fat intake during energy restriction were associated with plasma FA composition. The study also investigated if these changes were associated with changes in liver fat, liver stiffness and plasma lipids among persons with non-alcoholic fatty liver disease. Dietary and plasma FA were investigated in patients with non-alcoholic fatty liver disease (n48) previously enrolled in a 12-week-long open-label randomised controlled trial comparing two energy-restricted diets: a low-carbohydrate high-fat diet and intermittent fasting diet (5:2), to a control group. Self-reported 3 d food diaries were used for FA intake, and plasma FA composition was analysed using GC. Liver fat content and stiffness were measured by MRI and transient elastography. Changes in intake of total FA (r0·41;P= 0·005), SFA (r0·38;P= 0·011) and MUFA (r0·42;P= 0·004) were associated with changes in liver stiffness. Changes in plasma SFA (r0·32;P= 0·032) and C16 : 1n-7 (r0·33;P= 0·028) were positively associated with changes in liver fat, while totaln-6 PUFA (r−0·33;P= 0·028) and C20 : 4n-6 (r−0·42;P= 0·005) were inversely associated. Changes in dietary SFA, MUFA, cholesterol and C20:4 were positively associated with plasma total cholesterol and LDL-cholesterol. Modifying the composition of dietary fats during dietary interventions causes changes in the plasma FA profile in patients with non-alcoholic fatty liver disease. These changes are associated with changes in liver fat, stiffness, plasma cholesterol and TAG. Replacing SFA with PUFA may improve metabolic parameters in non-alcoholic fatty liver disease patients during weight loss treatment.
Correlations between X-rays, visible light and drive-beam energy loss observed in plasma wakefield acceleration experiments at FACET-II
Authors: Zhang Chaojie , Storey Doug , San Miguel Claveria Pablo , Nie Zan , Marsh Ken A. , Mori Warren B. , Adli Erik , An Weiming , Ariniello Robert , Cao Gevy J. , Clark Christine , Corde Sebastien , Dalichaouch Thamine , Doss Christopher E. , Emma Claudio , Ekerfelt Henrik , Gerstmayr Elias , Gessner Spencer , Hansel Claire , Knetsch Alexander , Lee Valentina , Li Fei , Litos Mike , O'Shea Brendan , White Glen , Yocky Gerry , Zakharova Viktoriia , Hogan Mark , Joshi Chan
Published: September 2024

This study documents several correlations observed during the first run of the plasma wakefield acceleration experiment E300 conducted at FACET-II, using a single drive electron bunch. The established correlations include those between the measured maximum energy loss of the drive electron beam and the integrated betatron X-ray signal, the calculated total beam energy deposited in the plasma and the integrated X-ray signal, among three visible light emission measuring cameras and between the visible plasma light and X-ray signal. The integrated X-ray signal correlates almost linearly with both the maximum energy loss of the drive beam and the energy deposited into the plasma, demonstrating its usability as a measure of energy transfer from the drive beam to the plasma. Visible plasma light is found to be a useful indicator of the presence of a wake at three locations that overall are two metres apart. Despite the complex dynamics and vastly different time scales, the X-ray radiation from the drive bunch and visible light emission from the plasma may prove to be effective non-invasive diagnostics for monitoring the energy transfer from the beam to the plasma in future high-repetition-rate experiments.
Available energy of plasmas with small fluctuations
Authors: Helander P. , Mackenbach R.J.J.
Published: September 2024

The available energy of a plasma is defined as the maximum amount by which the plasma energy can be lowered by volume-preserving rearrangements in phase space, so-called Gardner restacking. A general expression is derived for the available energy of a nearly homogeneous plasma and is shown to be closely related to the Helmholtz free energy, which it can never exceed. A number of explicit examples are given.
Spatial distribution of self-seeded air lasers induced by the femtosecond laser filament plasma
Authors: Zeng Tao , Li Nan , Yi Yuliang
Published: September 2024

The femtosecond laser filament-induced air laser plays a significant role for the remote sensing of air pollutants. The spatial distributions of air laser intensity were investigated experimentally in previous studies. However, the mechanism of the air laser propagation properties inside the filament plasma has not been quite clear yet. Moreover, few studies have been dedicated to the reproduction of the air laser profile from nitrogen molecules propagating in the filament plasma based on the numerical simulation method. In this study, the lasing action of the air laser from the transition of the first negative (0,0) band of nitrogen ions at 391 nm was simulated during the femtosecond laser filamentation. The beam profile of the air laser changes from a Gaussian or super-Gaussian shape to an outer ring structure by increasing the filament length or nitrogen ion density, which is in accord with the previous experimental result. A multiple-diffraction effect has been proposed to clarify the mechanism of the outer rings beam pattern formation, which is induced by the dynamical interaction between the lasing effect and diffraction effect of the air laser propagating inside the filament plasma. In addition, the amplified air laser power as a function of both the filament length and nitrogen ion density was investigated. Our study would pave the way to improve the energy conversion efficiency and directivity of remote air lasers, which would be significant for remote sensing applications.
Replacing a pillar of Tibetan Buddhist historiography: on the redactions of the so-called Pillar Testament (bKa’-chems-ka-khol-ma)
Authors: Langelaar Reinier
Published: September 2024

This article explores the unmined textual history of one of Tibet's most influential historiographies, the Pillar Testament (bKa’-chems-ka-khol-ma), usually dated to the eleventh or the twelfth century. Drawing on previously known and unknown witnesses, the article compares a variety of narratives across most extant redactions. In doing so, it finds that the redaction chiefly consulted by scholars to date is an expanded and contaminated version that is notably later than previously assumed. Instead, another and heretofore largely neglected witness emerges as the most archaic extant redaction. The textual comparisons spotlight a wide range of alterations in the work's narratives and thus demonstrate how perceptions of early Tibetan historical episodes shifted over time. Such changes affected remembrance of Sino-Tibetan imperial relations, the origins of Buddhism and writing in Tibet and the genealogy of its emperors, among other things. The article concludes by critically discussing the witnesses’ dating and the hope we may place in the hunt for the work's illustrious but elusive original.
IL TEMPIO MONUMENTALE REPUBBLICANO DI FALERII NOVI: RICERCHE STORICO-TOPOGRAFICHE SULL'INSULA XXXI (AREA 4)
Authors: Fochetti Beatrice
Published: September 2024

Between 1969 and 1975 the excavations promoted by the Soprintendenza alle Antichità dell'Etruria Meridionale in the area to the east of the church of Santa Maria of Falleri identified a building in opus quadratum, located at the intersection between the main east–west and north–south urban road axes. As part of the Falerii Novi Project, this area has been systematically surveyed and (re)studied, applying an interdisciplinary approach. This has allowed the identification in this area of a monumental republican temple, linked to the forum, which should be placed in the context of the earliest development of the town, which has been known to us up to now only via literary sources. The identification of the republican temple of Falerii Novi contributes to fresh insights into the foundation of the town and its urban development.
Optimal robot task scheduling in cluttered environments considering mechanical advantage
Authors: Zacharia Paraskevi Th. , Xidias Elias K.
Published: September 2024

In various industrial robotic applications, the effective traversal of a manipulator amidst obstacles and its ability to reach specific task-points are imperative for the execution of predefined tasks. In certain scenarios, the sequence in which the manipulator reaches these task-points significantly impacts the overall cycle time required for task completion. Moreover, some tasks necessitate significant force exertion at the end-effector. Therefore, establishing an optimal sequence for the task-points reached by the end-effector’s tip is crucial for enhancing robot performance, ensuring collision-free motion and maintaining high-force application at the end-effector’s tip.

To maximize the manipulator’s manipulability, which serves as a performance index for assessing its force capability, we aim to establish an optimal collision-free task sequence considering higher mechanical advantage. Three optimization criteria are considered: the cycle time, collision avoidance and the manipulability index. Optimization is accomplished using a genetic algorithm coupled with the Bump-Surface concept for collision avoidance. The effectiveness of this approach is confirmed through simulation experiments conducted in 2D and 3D environments with obstacles employing both redundant and non-redundant robots.
Optimal transport through a toll station
Authors: Stephanovitch Arthur , Dong Anqi , Georgiou Tryphon T.
Published: September 2024

We address the problem of optimal transport with a quadratic cost functional and a constraint on the flux through a constriction along the path. The constriction, conceptually represented by a toll station, limits the flow rate across. We provide a precise formulation which, in addition, is amenable to generalization in higher dimensions. We work out in detail the case of transport in one dimension by proving existence and uniqueness of solution. Under suitable regularity assumptions, we give an explicit construction of the transport plan. Generalization of flux constraints to higher dimensions and possible extensions of the theory are discussed.
Modelling habitat suitability for the Critically Endangered Manumea or Tooth-billed PigeonDidunculus strigirostrisusing past and present baselines
Authors: Gough William B. , Hudson Michael A. , Young H. Glyn , Wood Joe , Whitehead Hester , Turvey Samuel T.
Published: September 2024

Evidence-based conservation can be hindered by limited field data, but historical archives have the potential to provide unique insights into conservation-relevant parameters, such as identification of suitable habitat for threatened species. The Manumea or Tooth-billed PigeonDidunculus strigirostrishas declined on Samoa and only a tiny remnant population still persists, and a key first step for conservation is to locate surviving birds. Numerous Manumea records are available from the nineteenth century onwards, and we used historical and modern records to generate a series of species distribution models to predict the distribution of suitable habitat across Samoa to guide new field searches. Manumea distribution is closely associated with forest cover or its proxies. Preferred Manumea food plants are suggested to be low-elevation trees, but elevation provides relatively low percentage contribution in most models, thus not excluding the possibility that Manumea might occur at high elevations. There is also little evidence for elevational change in records over the past century. Models based on visual versus acoustic records exhibit differences in predicted habitat suitability, suggesting that some purported acoustic records might not actually represent Manumea calls. Field searches should target areas representing high habitat suitability across all models, notably the forested central axis of Upolu.
GPS tracking reveals the timing of collisions with powerlines and fences of three threatened steppe bird species
Authors: Marques Ana Teresa , Pacheco Carlos , Mougeot François , Silva João Paulo
Published: September 2024

Collision with powerlines is a major cause of mortality for many bird species, including bustards and sandgrouse. In this work, we used GPS tracking data to identify the hour of collision of three threatened steppe birds, i.e. Little Bustard Tetrax tetrax, Black-bellied Sandgrouse Pterocles orientalis, and Pin-tailed Sandgrouse Pterocles alchata. Out of a data set of 160 GPS-tracked individuals collected over a 13-year period, we detected eight collision events with powerlines or fences. Of these, we were able to determine the timing of 87.5% of the collision events with a resolution accurate to within two hours. Our results reveal that collisions occurred throughout the year and at different hours of the day, presenting a challenge for implementing effective mitigation strategies. The use of dynamic and reflective or luminescent devices may therefore be appropriate to prevent collision of steppe birds with powerlines during the day and night. Overall, this study adds evidence to the utility of using tracking data to better understand anthropogenic mortality in birds.
Internalizing and somatic symptoms influence the discrepancy between subjective and objective cognitive difficulties in adults with ADHD who have valid and invalid test scores
Authors: Finley John-Christopher A. , Robinson Anthony D. , VanLandingham Hannah B. , Ulrich Devin M. , Phillips Matthew S. , Soble Jason R.
Published: September 2024

Objectives:

This study investigated the relationship between various intrapersonal factors and the discrepancy between subjective and objective cognitive difficulties in adults with attention-deficit hyperactivity disorder (ADHD). The first aim was to examine these associations in patients with valid cognitive symptom reporting. The next aim was to investigate the same associations in patients with invalid scores on tests of cognitive symptom overreporting.

Method:

The sample comprised 154 adults who underwent a neuropsychological evaluation for ADHD. Patients were divided into groups based on whether they had valid cognitive symptom reporting and valid test performance (n = 117) or invalid cognitive symptom overreporting but valid test performance (n = 37). Scores from multiple symptom and performance validity tests were used to group patients. Using patients’ scores from a cognitive concerns self-report measure and composite index of objective performance tests, we created a subjective-objective discrepancy index to quantify the extent of cognitive concerns that exceeded difficulties on objective testing. Various measures were used to assess intrapersonal factors thought to influence the subjective-objective cognitive discrepancy, including demographics, estimated premorbid intellectual ability, internalizing symptoms, somatic symptoms, and perceived social support.

Results:

Patients reported greater cognitive difficulties on subjective measures than observed on objective testing. The discrepancy between subjective and objective scores was most strongly associated with internalizing and somatic symptoms. These associations were observed in both validity groups.

Conclusions:

Subjective cognitive concerns may be more indicative of the extent of internalizing and somatic symptoms than actual cognitive impairment in adults with ADHD, regardless if they have valid scores on cognitive symptom overreporting tests.
Nonseparability of credit card services within Divisia monetary aggregates
Authors: Barnett William A. , Park Hyun
Published: September 2024

We use the New Keynesian Dynamic Stochastic General Equilibrium (DSGE) framework and Vector Autoregressive (VAR) to investigate the usefulness and relevancy of monetary services, augmented to include credit card transaction services. We use the new credit-card-augmented Divisia monetary aggregates in the models to further the existing research on their usefulness and relevancy. In this research, we compare three different monetary aggregates within the New Keynesian framework: (1) the aggregation-theoretic “true” monetary aggregate, (2) the credit-card-augmented Divisia monetary aggregate, and (3) the simple sum monetary aggregate.

We acquire the following primary results. (1) The credit-card-augmented Divisia monetary aggregate tracks the theoretical (true) monetary aggregate, while simple sum does not. Although this result would be expected from the theory in classical economic models, the result is not an immediate implication of the theory in New Keynesian models and therefore needs empirical confirmation. (2) Under the recursive VAR framework, the credit-card-augmented Divisia monetary aggregate serves as a preferable monetary policy indicator compared to the traditional federal funds rate. (3) On theoretical grounds, we find that the separability condition for existence of a monetary aggregator function could fail, if credit card deferred payment services were excluded from the monetary services block, unless all markets are perfect.
Observation of significant photosynthesis in garden cress and cyanobacteria under simulated illumination from a K dwarf star
Authors: Vilović Iva , Schulze-Makuch Dirk , Heller René
Published: September 2024

Stars with about 45 to 80% the mass of the Sun, so-called K dwarf stars, have previously been proposed as optimal host stars in the search for habitable extrasolar worlds. These stars are abundant, have stable luminosities over billions of years longer than Sun-like stars, and offer favourable space environmental conditions. So far, the theoretical and experimental focus on exoplanet habitability has been on even less massive, though potentially less hospitable red dwarf stars. Here we present the first experimental data on the responses of photosynthetic organisms to a simulated K dwarf spectrum. We find that garden cress Lepidium sativum under K-dwarf radiation exhibits comparable growth and photosynthetic efficiency as under Solar illumination on Earth. The cyanobacterium Chroococcidiopsis sp. CCMEE 029 exhibits significantly higher photosynthetic efficiency and culture growth under K dwarf radiation compared to Solar conditions. Our findings of the affirmative responses of these two photosynthetic organisms to K dwarf radiation suggest that exoplanets in the habitable zones around such stars deserve high priority in the search for extrasolar life.
The ‘Perfect Storm’: Food Banks and Food Insecurity During the Covid-19 Pandemic
Authors: Pickering Sarah , Wood Jason
Published: September 2024

In the UK, food banks and other forms of food aid have become a normalised support mechanism for those living at the sharp end of poverty. Drawing from accounts of those who have used, worked, and volunteered in two of England’s food banks during the Covid-19 pandemic, this article explores some of the key challenges that emerged for food aid during this unique period. In documenting these experiences, the paper concurs with previous work that has identified the expanding role of food banks in providing core welfare support, suggesting an increasingly extended welfare function of food aid. This has implications for understanding the effectiveness of welfare – and the appropriateness of our reliance on voluntary aid – in the post-pandemic period.
Effectiveness of partial restriction of access to means in jumping suicide: lessons from four bridges in three countries
Authors: Shin Sangsoo , Pirkis Jane , Clapperton Angela , Spittal Matthew , Too Lay San
Published: September 2024

Aims

Restricting access to means by installing physical barriers has been shown to be the most effective intervention in preventing jumping suicides on bridges. However, little is known about the effectiveness of partial restriction with interventions that still allow jumping from the bridge.

Methods

This study used a quasi-experimental design. Public sites that met our inclusion criteria were identified using Google search and data on jumping suicides on Bridge A (South Korea), Bridges B and C (the United States) and Bridge D (Canada) were obtained from the relevant datasets. Incidence rate ratios (IRRs) were estimated using Poisson regressions comparing suicide numbers before and after the installation of physical structures at each site.

Results

Fences with sensor wires and spinning handrails installed above existing railings on the Bridge A, and fences at each side of the entrances and the midpoint of main suspension cables on the Bridge D were associated with significant reductions in suicides (IRR 0.37, 95% Confidence Interval (CI) 0.26 − 0.54; 0.26, 95% CI 0.09 − 0.76). Installation of bird spike on the parapet on the Bridge B, and fences at the front of seating alcoves on the Bridge C were not associated with changes in suicides (1.21, 95% CI 0.88 − 1.68; 1.49, 95% CI 0.56 − 3.98).

Conclusions

Partial means restriction (such as fences with sensor wires and spinning bars at the top, and partial fencing at selected points) on bridges appears to be helpful in preventing suicide. Although these interventions are unlikely to be as effective as interventions that fully secure the bridge and completely prevent jumping, they might best be thought of as temporary solutions before more complete or permanent structures are implemented.
Effort in Hindustani Dhrupad Singing: Using Interviews to Develop Effort Inference Models of Acoustic and Movement Features
Authors: PASCHALIDOU STELLA
Published: September 2024

This article sets out the results of research into effort in Dhrupad, a genre of Hindustani music. I examine gestural interactions with imaginary objects that vocalists outline when engaging with melodies. The study takes an embodied cognition stance and applies thematic analysis and inductive coding to original interviews with Dhrupad musicians in India, the UK, and the Netherlands. My findings demonstrate that from the singers’ cognitive perspectives, their hand movements are deeply connected to their voices. I also offer insights on the relationships between bodily movement, sound, and imagery that are used to inform the development of effort inference models.
Neurological outcomes and associated perinatal factors in infants born between 22 and 25 weeks with active care
Authors: Ariyoshi Yu , Iriyama Takayuki , Seyama Takahiro , Sayama Seisuke , Yano Eriko , Suzuki Kensuke , Samejima Taiki , Ichinose Mari , Toshimitsu Masatake , Sone Kenbun , Ito Atsushi , Shitara Yoshihiko , Kumasawa Keiichi , Kashima Kohei , Kakiuchi Satsuki , Hirota Yasushi , Takahashi Naoto , Osuga Yutaka
Published: September 2024

Objectives

To elucidate the outcomes of periviable infants receiving active care (AC) and explore perinatal factors associated with neurodevelopmental outcomes.

Methods

This is a single-center retrospective study on infants born at 22–25 weeks of gestation, all of whom received AC. A developmental quotient (DQ) ≥ 85 at corrected 18 months was judged as normal.

Results

Fifty-seven infants were included in the study. The survival rates at discharge were 83%, 86%, 93%, and 93% at 22, 23, 24, and 25 gestational weeks, respectively. The overall percentage of normal DQ was 26/47 (55%). Acidemia in the arterial blood gas measured within 6 h after birth was identified as a factor significantly associated with subnormal DQ.

Conclusions

Not only high survival rates, but also favorable neurodevelopmental outcomes may be achieved by AC in periviable infants. Moreover, impaired neurodevelopmental outcomes may be associated with early postnatal acidemia following initial resuscitation.
Pyroptosis of oral keratinocyte contributes to energy metabolic reprogramming of T cells in oral lichen planus via OPA1-mediated mitochondrial fusion
Authors: Yang Zaiwu , Deng Miao , Ren Lin , Fan Zhaona , Yang Shiwen , Liu Suyang , Ren Xianyue , Gao Jinlong , Cheng Bin , Xia Juan
Published: September 2024

Oral lichen planus (OLP) is a chronic inflammatory disease that is associated with an increased risk of carcinogenesis. The typical pathological features of OLP include submucosal T-cell banding, infiltration, and liquefactive degeneration of basal epithelial cells. However, the histological appearance of basal cell death cannot be explained by apoptosis of keratinocytes alone. The aim of this study was to explore a novel mechanism of epithelial cell death, pyroptosis, and its role in the development of OLP. The immunohistochemical results initially revealed pyroptosis in the epithelial cells of OLP. There was significant upregulation of pyroptosis-related inflammatory cytokines, specifically IL-1β. The expression of IL-1β is closely related to the severity of the patient’s condition. In vitro, the culture supernatant from epithelial cells and exogenous IL-1β significantly promote the proliferation and activation of T cells. This effect can be inhibited by neutralizing antibody or receptor inhibitor of IL-1β. Stimulation with exogenous IL-1β enhances both glycolysis and oxidative phosphorylation in T cells, with a more pronounced increase in glycolysis. This is due to the regulation of NAD+ availability and mitochondrial dynamics by IL-1β. IL-1β specifically stimulates the expression of optic atrophy 1 (OPA1), particularly L-OPA1, which promotes mitochondrial fusion and increases NAD+ availability. This process upregulated glycolysis in T cells. The knockdown of OPA1 reverses these changes by reducing the proliferation and activation of T cells. In this study, IL-1β promoted OPA1 transcription by activating the NF-κB pathway. The expression of OPA1 is inhibited by the inhibitor of NF-κB pathway. These results suggest that OLP keratinocytes undergo pyroptosis, which then secrete inflammatory factors that activate the NF-κB signaling pathway of T cells. This pathway regulates OPA1-mediated mitochondrial fusion and energy metabolism reprogramming in T cells, contributing to the development of OLP. These findings provide new insights into the mechanisms and therapeutic strategies for OLP.
Analysing the pedigree to identify undesirable losses of genetic diversity and to prioritize management decisions in captive breeding: a case study
Authors: Moreno Eulalia , Cervantes Isabel , Gutiérrez Juan Pablo , Fernández Iván , Goyache Félix
Published: September 2024

When prevention of species extinction is the priority, captive breeding is a key component in conservation programmes, allowing the recording of pedigree information in studbooks. The genealogical information registered in Cuvier’s gazelle studbook between 1975 and 2023 was analysed to (a) assess if the implemented mating policy was successful in preserving the genetic background of the founders (1 male:3 females) in the present population, and b) improve future management and breeding decisions. Although the maternal contribution of one founder female was lost and the mean inbreeding of the total live population was high (0.305 ± 0.095), the breeding policy applied produced better results than expected from a population starting from four founders. It was successful in keeping the individual increase in inbreeding low (0.047 ± 0.021), and, notably, the inbreeding tended to decrease during the last three decades of the breeding programme, ensuring the viability of this highly inbred population. Historical dissemination of individuals among the zoos of Europe and North America caused population structuring and genetic differentiation of the live North American population. However, it did not risk the viability of the captive population. The average relatedness coefficients allowed the identification of individuals with underrepresented genotypes, which is relevant to plan future mating guidelines to keep the founders’ representation balanced in the next generations. This study highlights the importance of keeping long-term pedigree information to monitor changes in the genetic diversity of captive populations, which is crucial to implement optimal mating decisions and assuring their long-term viability within an ex situ conservation programme.
Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial
Authors: Stanslaski Scott , Summers Rebekah L. S. , Tonder Lisa , Tan Ye , Case Michelle , Raike Robert S. , Morelli Nathan , Herrington Todd M. , Beudel Martijn , Ostrem Jill L. , Little Simon , Almeida Leonardo , Ramirez-Zamora Adolfo , Fasano Alfonso , Hassell Travis , Mitchell Kyle T. , Moro Elena , Gostkowski Michal , Sarangmat Nagaraja , Bronte-Stewart Helen ,   On behalf of the ADAPT-PD Investigators
Published: September 2024

Adaptive deep brain stimulation (aDBS) is an emerging advancement in DBS technology; however, local field potential (LFP) signal rate detection sufficient for aDBS algorithms and the methods to set-up aDBS have yet to be defined. Here we summarize sensing data and aDBS programming steps associated with the ongoing Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) pivotal trial (NCT04547712). Sixty-eight patients were enrolled with either subthalamic nucleus or globus pallidus internus DBS leads connected to a Medtronic PerceptTM PC neurostimulator. During the enrollment and screening procedures, a LFP (8–30 Hz, ≥1.2 µVp) control signal was identified by clinicians in 84.8% of patients on medication (65% bilateral signal), and in 92% of patients off medication (78% bilateral signal). The ADAPT-PD trial sensing data indicate a high LFP signal presence in both on and off medication states of these patients, with bilateral signal in the majority, regardless of PD phenotype.
Understanding flux switching in metabolic networks through an analysis of synthetic lethals
Authors: Narasimha Sowmya Manojna , Malpani Tanisha , Mohite Omkar S. , Nath J. Saketha , Raman Karthik
Published: September 2024

Biological systems are robust and redundant. The redundancy can manifest as alternative metabolic pathways. Synthetic double lethals are pairs of reactions that, when deleted simultaneously, abrogate cell growth. However, removing one reaction allows the rerouting of metabolites through alternative pathways. Little is known about these hidden linkages between pathways. Understanding them in the context of pathogens is useful for therapeutic innovations. We propose a constraint-based optimisation approach to identify inter-dependencies between metabolic pathways. It minimises rerouting between two reaction deletions, corresponding to a synthetic lethal pair, and outputs the set of reactions vital for metabolic rewiring, known as the synthetic lethal cluster. We depict the results for different pathogens and show that the reactions span across metabolic modules, illustrating the complexity of metabolism. Finally, we demonstrate how the two classes of synthetic lethals play a role in metabolic networks and influence the different properties of a synthetic lethal cluster.
Space radiation measurements during the Artemis I lunar mission
Authors: George Stuart P. , Gaza Ramona , Matthiä Daniel , Laramore Diego , Lehti Jussi , Campbell-Ricketts Thomas , Kroupa Martin , Stoffle Nicholas , Marsalek Karel , Przybyla Bartos , Abdelmelek Mena , Aeckerlein Joachim , Bahadori Amir A. , Barzilla Janet , Dieckmann Matthias , Ecord Michael , Egeland Ricky , Eronen Timo , Fry Dan , Jones Bailey H. , Hellweg Christine E. , Houri Jordan , Hirsh Robert , Hirvonen Mika , Hovland Scott , Hussein Hesham , Johnson A. Steve , Kasemann Moritz , Lee Kerry , Leitgab Martin , McLeod Catherine , Milstein Oren , Pinsky Lawrence , Quinn Phillip , Riihonen Esa , Rohde Markus , Rozhdestvenskyy Sergiy , Saari Jouni , Schram Aaron , Straube Ulrich , Turecek Daniel , Virtanen Pasi , Waterman Gideon , Wheeler Scott , Whitman Kathryn , Wirtz Michael , Vandewalle Madelyn , Zeitlin Cary , Semones Edward , Berger Thomas
Published: September 2024

Space radiation is a notable hazard for long-duration human spaceflight1. Associated risks include cancer, cataracts, degenerative diseases2 and tissue reactions from large, acute exposures3. Space radiation originates from diverse sources, including galactic cosmic rays4, trapped-particle (Van Allen) belts5 and solar-particle events6. Previous radiation data are from the International Space Station and the Space Shuttle in low-Earth orbit protected by heavy shielding and Earth’s magnetic field7,8 and lightly shielded interplanetary robotic probes such as Mars Science Laboratory and Lunar Reconnaissance Orbiter9,10. Limited data from the Apollo missions11–13 and ground measurements with substantial caveats are also available14. Here we report radiation measurements from the heavily shielded Orion spacecraft on the uncrewed Artemis I lunar mission. At differing shielding locations inside the vehicle, a fourfold difference in dose rates was observed during proton-belt passes that are similar to large, reference solar-particle events. Interplanetary cosmic-ray dose equivalent rates in Orion were as much as 60% lower than previous observations9. Furthermore, a change in orientation of the spacecraft during the proton-belt transit resulted in a reduction of radiation dose rates of around 50%. These measurements validate the Orion for future crewed exploration and inform future human spaceflight mission design.
One step from oxides to sustainable bulk alloys
Authors: Wei Shaolou , Ma Yan , Raabe Dierk
Published: September 2024

Metallurgical production traditionally involves three steps: extracting metals from ores, mixing them into alloys by liquid processing and thermomechanical processing to achieve the desired microstructures1,2. This sequential approach, practised since the Bronze Age, reaches its limit today because of the urgent demand for a sustainable economy2–5: almost 10% of all greenhouse gas emissions are because of the use of fossil reductants and high-temperature metallurgical processing. Here we present a H2-based redox synthesis and compaction approach that reforms traditional alloy-making by merging metal extraction, alloying and thermomechanical processing into one single solid-state operation. We propose a thermodynamically informed guideline and a general kinetic conception to dissolve the classical boundaries between extractive and physical metallurgy, unlocking tremendous sustainable bulk alloy design opportunities. We exemplify this approach for the case of Fe–Ni invar bulk alloys6,7, one of the most appealing ferrous materials but the dirtiest to produce: invar shows uniquely low thermal expansion6,8,9, enabling key applications spanning from precision instruments to cryogenic components10–13. Yet, it is notoriously eco-unfriendly, with Ni causing more than 10 times higher CO2 emission than Fe per kilogram production2,14, qualifying this alloy class as a perfect demonstrator case. Our sustainable method turns oxides directly into green alloys in bulk forms, with application-worthy properties, all obtained at temperatures far below the bulk melting point, while maintaining a zero CO2 footprint.
Temporal BMP4 effects on mouse embryonic and extraembryonic development
Authors: Hadas Ron , Rubinstein Hernan , Mittnenzweig Markus , Mayshar Yoav , Ben-Yair Raz , Cheng Saifeng , Aguilera-Castrejon Alejandro , Reines Netta , Orenbuch Ayelet-Hashahar , Lifshitz Aviezer , Chen Dong-Yuan , Elowitz Michael B. , Zernicka-Goetz Magdalena , Hanna Jacob H. , Tanay Amos , Stelzer Yonatan
Published: September 2024

The developing placenta, which in mice originates through the extraembryonic ectoderm (ExE), is essential for mammalian embryonic development. Yet unbiased characterization of the differentiation dynamics of the ExE and its interactions with the embryo proper remains incomplete. Here we develop a temporal single-cell model of mouse gastrulation that maps continuous and parallel differentiation in embryonic and extraembryonic lineages. This is matched with a three-way perturbation approach to target signalling from the embryo proper, the ExE alone, or both. We show that ExE specification involves early spatial and transcriptional bifurcation of uncommitted ectoplacental cone cells and chorion progenitors. Early BMP4 signalling from chorion progenitors is required for proper differentiation of uncommitted ectoplacental cone cells and later for their specification towards trophoblast giant cells. We also find biphasic regulation by BMP4 in the embryo. The early ExE-originating BMP4 signal is necessary for proper mesoendoderm bifurcation and for allantois and primordial germ cell specification. However, commencing at embryonic day 7.5, embryo-derived BMP4 restricts the primordial germ cell pool size by favouring differentiation of their extraembryonic mesoderm precursors towards an allantois fate. ExE and embryonic tissues are therefore entangled in time, space and signalling axes, highlighting the importance of their integrated understanding and modelling in vivo and in vitro.
Mars’s induced magnetosphere can degenerate
Authors: Zhang Qi , Barabash Stas , Holmstrom Mats , Wang Xiao-dong , Futaana Yoshifumi , Fowler Christopher M. , Ramstad Robin , Nilsson Hans
Published: September 2024

The interaction between planets and stellar winds can lead to atmospheric loss and is, thus, important for the evolution of planetary atmospheres1. The planets in our Solar System typically interact with the solar wind, whose velocity is at a large angle to the embedded stellar magnetic field. For planets without an intrinsic magnetic field, this interaction creates an induced magnetosphere and a bow shock in front of the planet2. However, when the angle between the solar wind velocity and the solar wind magnetic field (cone angle) is small, the interaction is very different3. Here we show that when the cone angle is small at Mars, the induced magnetosphere degenerates. There is no shock on the dayside, only weak flank shocks. A cross-flow plume appears and the ambipolar field drives planetary ions upstream. Hybrid simulations with a 4° cone angle show agreement with observations by the Mars Atmosphere and Volatile Evolution mission4 and Mars Express5. Degenerate, induced magnetospheres are complex and not yet explored objects. It remains to be studied what the secondary effects are on processes like atmospheric loss through ion escape.