bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of B cell Activating Factor (BAFF) expression on pathogenesis of nasal polyp in chronic rhinosinusitis with nasal polyposis
Authors: Hoon Yoon Young , Jin Jun , Ryun Kwon Ki , Ha Kim Sung , Rha Ki-Sang , Min Kim Yong
Published: January 2022

Background: B cells, plasma cells, and local immunoglobulins, are important as a mucosal immune barrier function, and tend to increase in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). However, their association with eosinophils' aggregation has not been fully understood. The objectives of this study was to explore whether BAFF expression in the subepithelial area in nasal polyp tissues of CRSwNP was associated with eosinophils' accumulation, and also to evaluate cells which cells produce BAFF. Methodology: Immunohistochemical and immunofluorescence staining were used to analyse expression of BAFF, CD20, immunoglobulin A (IgA) and a proliferation inducing ligand (APRIL) on nasal tissues from CRSwNP patients to control subjects. To identify the relationship between BAFF and tissue eosinophilia, CRSwNP subjects were divided into eosinophilic polyp and non-eosinophilic groups. Double immunofluorescence analysis for BAFF and CD11c or CD11b was performed to identify cells producing BAFF. Results: The numbers of BAFF, CD20, and IgA-positive cells in the subepithelial area were significantly higher in the CRSwNP group (both eosinophilic polyps and non-eosinophilic polyps. There were statistically significant correlations between the number of BAFF and CD20-positive cells, CD20 and IgA-positive cells, and BAFF and IgA-positive cells. CD11b-positive were co-localized with BAFF positive cells. Conclusion: The subepithelial expression of BAFF was associated with increased number of B cells and plasma cells, and increased production of IgA in the patients with CRSwNP, especially eosinophilic nasal polyps. Therefore, BAFF-induced IgA production may be associated with eosinophils' aggregation and degranulation, which cause aggravation of tissue inflammation and finally polyp formation. The expression of BAFF in the subepithelial area may be associated with innate inflammatory cells (CD11b+ cells), such as monocytes, granulocytes, macrophages, and natural killer cells.
Abundance and Distribution of the Hyponeustonic Copepods Anomalocera patersonii and Pontella mediterranea in the South-western Part of the Black Sea
Authors: Harcotă George-Emanuel , Țotoiu Aurelia , Bișinicu Elena , Tabarcea Cristina , Boicenco Laura , Timofte Florin
Published: January 2022

The paper presents the analysis of hyponeustonic species present in the south-western part of the Black Sea, in October 2019, within the ANEMONE Project. From the qualitative and quantitative point of view, two species were identified: Anomalocera patersonii Templeton, 1837 (WoRMS) and Pontella mediterranea Claus, 1863 (WoRMS). The analyzed samples showed significant densities of these species, being found in different development stages, from nauplii to copepodites but also as adults and having a representative distribution on the entire analyzed surface. A. patersonii was abundant in the northern part of the Romanian marine area, the southern marine area of Bulgaria and in Turkey central area, while P. mediterranea recorded a higher abundance in the Romanian Black Sea area.
Relationship Between Latent Heat Flux and Sea Surface Temperature in Alexandria Eastern Harbor, Egypt
Authors: Hussein Maged M.A.
Published: January 2022

The immersed sensor data in Alexandria Eastern Harbor (AEH) are analyzed to explore the relation between latent heat flux (LHF) from the AEH and the sea surface temperature (SST). Output results represent that the LHF continued to rise with SST≥292K, while LHF increases with decreasing SST at SSTs lower than 292 K, However, the relationship cannot be expounded by thermodynamic investigation alone. Consequently, the analysis of humidity differences (Δq) and wind speeds represent that the Δq primarily determines the sharp increase in LHF while at high SST, and a decrease in wind speed is mostly responsible for the low LHF at low SST. The temporal analysis of the two time periods, namely ≤90 days (seasonal time scale) and ≤30 days (monthly timescale), reveals that high LHF above warm SST was operative on the two time periods. The cross-correlation between SST and LHF on these time periods was characterized by a one-day lag with correlation coefficients of 0.47 and 0.25, respectively.
Об усредненных отображениях в $\operatorname{CAT}(0)$-пространствах
Authors: Berdellima Arian
Published: January 2022

В статье вводится понятие усредненного отображения в расширенном классе $\operatorname{CAT}(0)$-пространств.
Мы называем такое отображение $\alpha$-твердо нерастягивающим и выводим основные правила
исчисления квази-$\alpha$-твердо нерастягивающих отображений с общей неподвижной точкой.
Мы показываем, что итерации $x_n:=Tx_{n-1}$ нерастягивающего отображения $T$ слабо сходятся к точке
пространства $\operatorname{Fix} T$, если $T$ является квази-$\alpha$-твердо нерастягивающим. При этом
отображения $P_{\operatorname{Fix} T}x_n$ сильно сходятся к этому слабому пределу. Построенная теория проиллюстрирована
двумя классическими примерами применения методов циклических и усредненных проекций.
Многочлены от оператора дифференцирования и формулы для сумм некоторых сходящихся рядов
Authors: Mirzoev Karakhan Agahan ogly , Safonova Tatyana Anatolievna
Published: January 2022

Пусть $P_n(x)$ - произвольный многочлен степени $n\geq 2$ с вещественными коэффициентами, такой, что $P_n(k)\ne 0$ при $k\in\mathbb{Z}$. В данной работе получены, в частности, формулы для суммы ряда вида $\sum_{k=-\infty}^{+\infty}1/P_n(k)$ как значения в точке $(0,0)$ функции Грина самосопряженной задачи, порожденной дифференциальным выражением $l_n[y]=P_n(i d/dx) y$ и граничными условиями $y^{(j)}(0)=y^{(j)}(2\pi)$ ($j=0,1,…,n-1$). Таким образом, эта сумма непосредственно выражаются через значения легко конструируемой элементарной функции. Эти формулы, очевидно, относятся и к сумме вида $\sum_{k=0}^{+\infty}1/P_n(k^2)$, а невозможность существования подобных общих формул для суммы $\sum_{k=0}^{+\infty}1/P_n(k)$ хорошо известна.
Значения $\mathfrak{sl}_2$-весовой системы на семействе графов, не являющихся графами пересечений хордовых диаграмм
Authors: Zinova Polina Aleksandrovna
Published: January 2022

Теорема Чмутова-Ландо утверждает, что значение весовой системы (функции на хордовых диаграммах, удовлетворяющей четырехчленным соотношениям Васильева), отвечающей алгебре Ли $\mathfrak{sl}_2$, зависит лишь от графа пересечений хордовой диаграммы.
Мы вычисляем значения $\mathfrak{sl}_2$-весовой системы на графах нескольких бесконечных серий, представляющих собой соединение графа с малым числом вершин с дискретным графом. В частности, мы вычисляем эти значения для серии, в которой исходный граф является циклом на пяти вершинах; все графы этой серии, за исключением начального, не являются графами пересечений.
Мы также выводим формулу для проекций производящих функций графов, представляющих собой соединение произвольного графа с дискретным, на подпространство примитивных элементов в алгебре Хопфа графов. Воспользовавшись полученной формулой, мы вычисляем значения $\mathfrak{sl}_2$-весовой системы на проекциях графов указанных серий на подпространство примитивных элементов. Наши вычисления подтверждают гипотезу С. К. Ландо о значениях $\mathfrak{sl}_2$-весовой системы на проекциях на подпространство примитивных.
Библиография: 17 названий.
Критерий гиперболичности одного класса диффеоморфизмов на бесконечномерном торе
Authors: Glyzin Sergey Dmitrievich , Kolesov Andrei Yurevich
Published: January 2022

На бесконечномерном торе $\mathbb{T}^{\infty} {=} E/2\pi\mathbb{Z}^{\infty}$,
где $E$ - бесконечномерное вещественное банахово пространство, $\mathbb{Z}^{\infty}$ - абстрактная целочисленная решетка, рассматривается специальный класс диффеоморфизмов $\operatorname{Diff}(\mathbb{T}^{\infty})$. Упомянутый класс состоит из отображений $G\colon \mathbb{T}^{\infty}\to\mathbb{T}^{\infty}$, представляющих собой суммы линейных обратимых ограниченных операторов, сохраняющих решетку $\mathbb{Z}^{\infty}$, и $C^1$-гладких периодических добавок. Устанавливаются необходимые и достаточные условия, гарантирующие гиперболичность таких отображений (т.е. принадлежность их к диффеоморфизмам Аносова).
Библиография: 15 названий.
Detection of antibodies to H5 and H9 subtypes of influenza viruses in wild birds in Zaria, Nigeria
Authors: Wungak Y.S. , Orakpoghenor O. , Bitrus I. , Olawuyi K.A. , Osemeke O.H. , Ularamu H.G. , Shittu I. , Meseko C.A.
Published: January 2022

Avian influenza has impacted negatively on poultry production in Nigeria. The aim of this study was to determine the status of avian influenza virus (AIV) antibodies in wild birds to provide early warning of an outbreak. One hundred and forty-six sera from five different species of wild birds were tested for antibodies to avian influenza A viruses (H5 and H9) using enzyme linked immunosorbent assay and haemagglutination inhibition (HI) tests. An overall seroprevalence of 3.4% (5/146) was recorded in the study area. Seroprevalence of 6.67% (2/30) was recorded in speckled pigeons (Columba guinea) and Village weavers (Ploceus cucullatus) respectively and 3.33% (1/30) in Cattle egrets (Bubulcus ibis). No antibodies were detected in laughing doves (Spilolepia senegalensis) and African silver bill (Euodice cantans). The serological detection of AIV subtypes H5 and H9 by HI showed the exposure of these birds to the two subtypes. The result from this study indicates evidence of the presence of H5 and H9 AI viruses in wild birds in Zaria, Kaduna State. Therefore, comprehensive surveillance of influenza A involving wild birds’ population and H5 as well as H9 subtype is recommended. This is necessary in order to know the actual status of these strains in the poultry population in Nigeria in view of their zoonotic and economic importance.
Zhitong Jiangu decoction mitigates osteoarthritis in rabbits via regulation of NF-κB signaling pathway
Authors: Xiaodong Li , Xinping Su , Xuyi Tan , Haien Luo , Canyu He , Gang Huang , Daowei Zhang , Kejian Zhu
Published: January 2022

Purpose: To investigate the effect of Zhitong Jiangu decoction (ZJD) on osteoarthritis rabbits, and the mechanism of action involved.

Methods: Chondrocytes were obtained from the knees of osteoarthritic rabbits. These chondrocytes were randomly assigned to 7 groups: sham, 5, 10 and 20 % normal serum groups; 5 % ZJD, 10 % ZJD and 20 % ZJD groups. The gross and histopathological features of the rabbit cartilage were examined by microscopy. Each group was treated with a different concentration of rabbit normal serum or rabbit drug-containing serum. The protective effect of different concentrations of ZJD on the cells were determined. Cell proliferation and concentrations of IL-1 and MMP-3 were determined using cell counting kit (CCK) 8 and enzyme-linked immunosorbent assay (ELISA), respectively. The mRNA and protein expressions of inhibitor of nuclear factor-κB kinase α (IKK-α) and nuclear factor kappa B p65 (NF- κB p65) were determined by quantitative reverse transcription polymerase chain reaction (qRT- PCR) and immunoblotting, as appropriate.

Results: Gross and histopathological examinations of rabbit cartilage showed that osteoarthritis was successfully established in rabbit knee joint. Cell proliferation significantly and time- and concentration-dependently increased in drug-containing serum groups, relative to sham and normal serum-containing groups. However, expressions of NF-κB p65, IL-1, MMP-3 and IKK-α were markedly and time- and concentration-dependently reduced in drug-containing serum groups, relative to sham and normal serum-containing groups (p < 0.05).

Conclusion: These results indicate that ZJD mitigates osteoarthritis in rabbits via regulation of NF-κB signaling pathway. Thus, it can potentially be developed for the management of osteoarthritis.
Computational design of phosphoinositide 3-kinase gamma (PI3Kg) inhibitors as a newer therapy for rheumatoid arthritis
Authors: Tang Haiyan , Ren Kai , Wang Guanjie , Zhang Rong , Zhang Long
Published: January 2022

Purpose: To develop a potential therapy for rheumatoid arthritis (RA) by altering factors involved in the pathogenesis of the disease.

Methods: Molecular docking simulation-based virtual screening was performed against phosphoinositide-3-kinase gamma (PI3Kg) to identify potential leads that may serve as anti-rheumatoid arthritic agents through their interactions and binding energies with the target receptor, followed by their optimization for improvement of their pharmacokinetics and toxicity profiles.

Results: Molecular docking simulation-based virtual screening and computational toxicity profiling predicted that the lead compounds ZINC04376856, ZINC01729526, ZINC01045089, ZINC03954520, ZINC01738764, and ZINC01163259 were potent PI3Kg inhibitors.

Conclusion: These lead compounds exert potent inhibitory effects on human PI3Kg receptor. Thus, they need to be experimentally validated for use in the development of novel drugs for treating RA in humans.
Molecular docking and dynamic simulation study to explore quercetin as a multi-potent candidate against gliomas
Authors: Rizvi Syed Mohd Danish , Hussain Talib , Mehmood Khalid , Moin Afrasim , Alanazi Abulrahman Sattam , Subaiea Gehad M.
Published: January 2022

Purpose: To search for novel gliomas targets and their inhibitors using a molecular docking approach.

Methods: Quercetin multi-targeting potential was investigated against some of the emerging gliomas targets such as epidermal growth factor receptor (EGFR), ephrin type-A receptor 2 (EphA2), nicotinamide phosphoribosyltransferase (NMRPTase) and plasminogen activator inhibitor-1 (PAI-1). Crucial biochemical interaction of quercetin with these targets were analyzed using molecular docking study.

Results: Quercetin interacted strongly via hydrogen bonding with important active sites consisting of amino acid residues of EphA2 and PAI-1, and showed binding energy of -7.44 and -7.38 kcal/mol, respectively. Some crucial active site amino acids involved in the interaction of known EphA2 and PAI-1 inhibitors (Alw-II-41-27 and ACT001) were common in quercetin interactions as well, and both inhibitors as well as quercetin did not violate Lipinski rules. Importantly, the quercetin-EphA2 and quercetin-PAI-1 complexes were stable as minimal fluctuations within the permissible limit were observed during a 20 ns trajectory performed on desmond simulation platform.

Conclusion: Despite the fact that quercetin has been studied extensively against various cancer pathways, its transformation from a long-time bench candidate into bedside medications still needs further exploration. Nevertheless, the present predictive biochemical interaction analysis against emerging glioma targets might pave way for the design of novel therapeutic agents based on quercetin scaffolds.
Effect of soil type on chemical composition and antioxidant properties of Solanum nigrum (L.) shoot oil extracts
Authors: Ogundola Adijat F. , Bvenura Callistus , Afolayan Anthony J.
Published: January 2022

Purpose: To investigate the effect of different soil textures on chemical composition and antioxidant properties of essential oils from Solanum nigrum.

Methods: Four soils of differing texture were formulated from soil under fallow to cultivate S. nigrum in a glasshouse. Essential Oil was extracted from fresh shoots by solvent-free microwave extraction (SFME) and analysed using gas chromatography-mass spectrometry (GC-MS). Antioxidant properties were assayed (DPPH) and ABTS

Results: GC-MS profiling revealed variations in the quality index (QI), number of chemical constituents and antioxidant results of S. nigrum oil. Geraniol and citronellol were the two principal components. The highest activity of the antioxidant was found in plants cultivated on clay loam soil. Fifty percent (50%) Inhibitory Concentration (IC50) ranged from 1.196 to 1.594 μg/mL and 0.067 to 3.59 μg /mL in DPPH and ABTS assays, respectively.

Conclusions: This research work indicates that soil texture influences the oil quality, quantity and chemical composition of oil extracted from S. nigrum shoots. Essential oil extracts from S. nigrum grown on clay loam soils recorded the highest antioxidant properties.
Effect of propofol and sevoflurane on perioperative and postoperative outcomes in lung cancer patients after thoracoscopic surgery
Authors: Zhou Ying , Xu Ting
Published: January 2022

Purpose: To investigate the effects of propofol and sevoflurane on intraoperative and postoperative outcomes of lung cancer patients after thoracoscopic surgery.

Methods: Lung cancer patients (n = 265) aged 51 – 73 years (mean age = 62 ± 11 years) who underwent thoracoscopic surgery under propofol or sevoflurane anesthesia were recruited over a 2-year period for this study. Data on perioperative pulmonary function, inflammatory responses, awakening time, postoperative pain and adverse reactions, pre- and postoperative cognitive functions, as well as duration of hospital stay were retrospectively analyzed.

Results: Perioperative pulmonary function was poor in patients who were operated under sevoflurane, relative to those who were operated under propofol (p < 0.05). After sternal closure (just before one-lung ventilation), levels of serum of interleukin 6 (IL-6), matrix metalloproteinase 9 (MMP-9), and S100β protein were reported to be higher in patients of sevoflurane group than those in propofol group, but interleukin 10 (IL-10) level was markedly reduced in sevoflurane group, relative to propofol group (p < 0.05). Awakening times and visual analog scale score of patients 24 h after thoracoscopic surgery of patients in sevoflurane group were significantly higher than those in propofol group (p < 0.05).

Conclusion: These results indicate that propofol is more effective than sevoflurane in the protection of pulmonary and cognitive functions of patients after thoracoscopic surgery. Thus, intravenous propofol anesthesia is recommended for thoracoscopic surgery for lung cancer.
Potential regulatory effects of CXCR2 and CPEB1 on cardiac cachexia
Authors: Li Yang , Zhang Congyu , Tong Qian , Feng Xiaoxing
Published: January 2022

Purpose: To investigate the effect of C-X-C motif chemokine receptor 2 (CXCR2) and cytoplasmic polyadenylation element binding protein 1 (CPEB1) which are linked to inflammatory and cellular senescence, on cardiac cachexia.

Methods: Early and advanced stages of cardiac cachexia were established in mice using exogenous injection of single doses of growth differentiation factor 11 (GDF11, 3.0 and 6.0 mg/kg, respectively). The expressions of CXCR2 and CPEB1 were assayed using immonohistochemistry and Western blotting.

Results: Following two weeks of GDF11 injection, cardiac tissue mass was reduced by 23 and 39 % in early and advanced stages cardiac cachexia, respectively, in mice. Histology showed progressive loss of cardiac muscle and cardiomyocyte shrinkage in early stage, with extensive cardiac muscle wasting and disruption of cardiac arche structure in the advanced stage. Immunohistochemistry and Western blotting showed that CXCR2 was 4.6 times overexpressed in the initial stage of cachexia, but was restricted to only 2.4-fold overexpression in advanced stage of cardiac cachexia. The results showed that CXCR2 and its higher expression in early stages of cardiac cachexia prepared the cardiac microenvironment for vast changes during which its expression was limited. There were 2.2-fold and 5.5-fold higher expressions of CPEB1 in early and advanced stages of cardiac cachexia, respectively, indicating its role in cardiac muscle wasting and remodelling in cellular senescence.

Conclusion: CXCR2 overexpression modulates extensive cardiac muscle loss in cardiac cachexia, thus affording a strategy for the management of this pathological condition.
Over-expression of miR-124 impairs proliferation, invasion and epithelial-mesenchymal transition in pituitary prolactinoma by targeting PHD finger protein 19
Authors: Li Zongxi , Ren Lingxuan , Wang Shoujie
Published: January 2022

Purpose: To determine the effect of miR-124 in pituitary prolactinoma.

Methods: The viability and proliferation of prolactinoma cells were investigated using Cell Counting Kit-8 and 5-ethynyl-2′-deoxyuridine staining assays. Cell migration and invasion were investigated using the transwell assay. The epithelial-mesenchymal transition was investigated using western blotting. The target gene of miR-124 was verified by the luciferase activity assay.

Results: The viability and proliferation of prolactinoma cells were repressed by miR-124 over-expression (p < 0.01). Forced miR-124 expression suppressed prolactinoma cell migration and invasion (p < 0.01). E-cadherin expression was enhanced, while N-cadherin and vimentin were reduced, by miR- 124 over-expression (p < 0.01). PHF19 (plant homeodomain-like finger protein 19) contains an miR-124 binding site, and PHF19 over-expression enhanced cell proliferation, promoted cell migration and invasion, reduced E-cadherin expression and enhanced N-cadherin and vimentin expression in prolactinoma cells. Additionally, miR-124 mimic-induced suppression of prolactinoma cell growth and metastasis was attenuated by forced PHF19 expression.

Conclusion: MiR-124 retards prolactinoma cell growth and metastasis by reducing PHF19, providing a promising therapeutic target for prolactinoma.
Is laparoscopic major hepatectomy feasible and safe in Swiss cantonal hospitals?
Authors: Heid Franziska , Toti Johannes , Balzarotti Canger Ruben C. , Cristaudi Alessandra , Breitenstein Stefan , Majno-Hurst Pietro , Schadde Erik
Published: January 2022

BACKGROUND: The number of laparoscopic liver resections is increasing worldwide, including in Switzerland. However, laparoscopy is mostly used for minor resections. Little is known about indications for and outcomes of major liver resections performed laparoscopically. The aim of this study was to compare the clinical outcome of open and laparoscopic major liver resection cohorts in two Swiss centres.
METHODS: Patients undergoing open or laparoscopic major hepatectomy (>3 segments) in two cantonal hospitals from January 2015 to December 2019 were analysed. All disease types except perihilar cholangiocarcinomas, rare malignancies and resections with biliary reconstruction were included. The primary outcome was the number of complications incurred. Operation time, blood loss, hospital stay and 90-day mortality were secondary outcomes investigated. A separate analysis was performed for colorectal liver metastases, the most common indication. Potential risk factors for major complications were evaluated in a multivariate analysis.
RESULTS: A total of 88 patients were identified. Among those, 34 patients underwent laparoscopic major hepatectomy (LAPH) and 54 patients open major hepatectomy (OH). The two groups did not differ in demographics. The most common indication was malignancy (LAPH 94% vs OH 98%), mainly colorectal liver metastases (LAPH 53% vs OH 59%). There was no significant difference in major complications (21% vs 15%, p = 0.565). Median operation time (LAPH 433 minutes, interquartile range [IQR 351–482  vs OH 397 minutes, IQR 296–446; p = 0.222), blood loss (325 ml, IQR 200–575 vs 475 ml, IQR 300–800; p = 0.150) and hospital stay (9 days, IQR 8–14 vs 11 days, IQR 9–14; p = 0.441) were comparable between the two cohorts. There was no significant difference in 90-day mortality (3% vs 7%, p = 0.881). The laparoscopic technique was not identified as a risk factor for major complications in a multivariate analysis.
CONCLUSION: This first report from Switzerland evaluating outcomes of laparoscopic major hepatectomies showed no difference in complications and clinical non-inferiority compared with open major hepatectomy.
Development of a value-based healthcare delivery model for sarcoma patients
Authors: Fuchs Bruno , Studer Gabriela , Bode Beata , Wellauer Hanna , Frei Annika , Theus Carlo , Schüpfer Guido , Plock Jan , Windegger Hubi , Breitenstein Stefan
Published: January 2022

The urgent need to restructure healthcare delivery to address rising costs has been recognised. Value-based health care aims to deliver high and rising value for the patient by addressing unmet needs and controlling costs. Sarcoma is a rare disease and its care is therefore usually not organised as an institutional discipline. It comprises a set of various diagnostic entities and is highly transdisciplinary. A bottom-up approach to establishing sarcoma integrated practice units (IPUs) faces many challenges, but ultimately allows the scaling up of quality and outcomes of patient care, specific knowledge, experience and education. The key for value-based health care – besides defining the shared value of quality – is an integrated information technology platform that allows transparency by sharing values, brings all stakeholders together in real-time,  and offers the opportunity to assess quality of care and outcomes, thereby ultimately saving costs. Sarcoma as a rare disease may serve as a  model of how to establish IPUs through a supraregional network by increased connectivity, to advance patient care, to improve science and education, and to control costs in the future, thereby restructuring healthcare delivery. This article describes how the value-based health care delivery principles are being adopted and fine-tuned to the care of sarcoma patients, and already partially integrated in seven major referral hospitals in Switzerland.
Critical incident reporting over time: a retrospective, descriptive analysis of 5493 cases
Authors: Jäger Christoph , Mohr Giulia , Gökcimen Ken , Navarini Alexander , Schwendimann René , Müller Simon
Published: January 2022

PURPOSE: As recommended by the WHO and many national healthcare authorities, health care institutions of most industrialised countries have employed a critical incident reporting system (CIRS). However, little is known about differences in critical incidents across clinical specialties, the use of CIRSs amongst different professional groups, the types, severity and risk of reoccurrence of critical incidents, their contributing factors and the preventive actions taken in response.
METHODS: In this retrospective, descriptive study we critically reviewed all reports filed in the CIRS of our institution between 2013 and 2019 and analysed characteristics over time.
RESULTS: Of the 5493 analysed incidents, the main types were related to medications (32.8%), clinical procedures (32.6%) or behaviour of employees (23.3%). Only 21.6% of reports were made by physicians, 51.3% were rated at least “high risk”. Major contributing factors were personal factors (44.0%), lack of training and knowledge (43.7%) and communication errors (36.1%). Most actions taken to prevent similar events aimed at improving communications (23.6%); in 46.3% no actions whatsoever were taken. Longitudinal analysis revealed that reporting increased in internal medicine and obstetrics but collapsed in laboratory medicine / microbiology. Steady increases in medication-type incidents as well as lack of training and knowledge as contributing factors were observed.
CONCLUSION: This study revealed that the efferent loop (feedback, preventive actions taken) was the weakest part of the CIRS in our institution, indicating that no learning may have resulted from a large number of reports. In particular, the actions taken appeared to not adequately address the major contributing factors. This highlights that special attention must be paid to the efferent loop of a CIRS to fulfil the purpose of such a reporting system and ultimately to improve patient safety.
Seroprevalence of the SARS-CoV-2 virus in the population of the southern Switzerland (Canton Ticino) – cohort study, results at 12 months
Authors: Beretta Ottavio , Casati Pagani Simona , Lazzaro Mario , Merlani Giorgio , Bouvier Gallacchi Martine
Published: January 2022

AIMS OF THE STUDY: A new emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in Wuhan, China, in December 2019 and then spread rapidly, causing a global pandemic. In Europe, the first case was identified in Italy on 21 February 2020, in the Lombardy region bordering on the southern part of Switzerland (Canton Ticino), where 4 days later the first case was identified . Ticino was the most affected canton in Switzerland during the first wave of pandemic. In order to provide a reliable indicator for the spread of the virus in this region and help decision making at the public health level, a seroprevalence study of SARS-CoV-2 was conducted.
METHODS: A cohort study was implemented on a randomly selected sample of 1500 persons. The sample is representative of the general population of the Canton of Ticino, stratified by sex and age from 5 years old.  Antibodies against the SARS-CoV-2 nucleocapsid protein were detected using a rapid qualitative test in 4 data collection periods over the course of 12 months (from May–June 2020 to May–June 2021).
RESULTS: The seroprevalence of SARS-CoV-2 was estimated at 9.0% in spring 2020 (weeks 20–26), 8.4% in summer 2020 (weeks 32–38), 14.1% in autumn 2020 (weeks 45–52) and 22.3% in spring 2021 (weeks 18–23). In none of these four phases was evidence of an association between sex or specific age groups and presence of anti-SARS-CoV-2 antibodies detected. For risk factors, the only strong and significant association found was with diabetes in the first three data collection periods but not in the fourth. Among people who participated in all four phases of the study and tested positive anti-SARS-CoV-2 antibodies in the first test, 61.8% were still positive even in the fourth, 12 months later.
CONCLUSIONS: The results support the hypothesis that, after one year and despite the severe burden in terms of hospitalisations and deaths experienced by the Canton Ticino, SARS-CoV-2 infection affected only a minority of the population (20%) and also suggest that the anti-nucleocapsid antibodies persist after 12 months in the majority of infected persons.
How Liberal education makes humans free －Historical review of competence based Liberal education to advocate for Liberal education
Authors: Han Soo young
Published: January 2022

Liberal education has represented the ideal and standard form of education that contains the essential value of education. Liberal education values the exploration of knowledge that holds truth beyond life. This is because knowledge itself has an intrinsic value of being “liberal.” Nonetheless, how being “liberal” actually liberates human beings cannot be explained. This very characteristic of liberal education has been criticized for making knowledge a priori dogma and for distancing people from the fullness of real life.
Liberal education, an elite education for liberal citizens, is known to be exclusive and removed from the reality of the working class. While it is concentrated on the input of knowledge, it shows a structural vulnerability that it neglects in the output. Therefore, the demand for a specific curriculum and observable consequences that would liberate humans was bound to appear constantly. Competence-based education grew against this backdrop, and liberal education gradually diminished in importance due to being seen as overly speculative, old fashioned, and disconnected from reality.
As the social demand for professional education intensifies, liberal education is being used as a symbolic myth that grants rhetorical justification to vocational education. Efforts to transform liberal education into competency-oriented training may backfire and often weaken the originality of liberal education and produce self-negating outcomes.
The cooperation between liberal education and competency-based education should begin again not by meeting half-way, but by acknowledging differences and recognizing potential elements of conflict.
An Autobiographical Case Study on University’s Writing Class Operated in a Synchronous Online Manner －Focusing on the Perception and Reflection of Instructors through the Subject of Writing and Classical Reading at the University of Suwon
Authors: Yang Sooyeon , Kim Hyejin
Published: January 2022

The purpose of this study is to analyze autobiographical cases in which the university of Suwon's essential liberal arts subject called “Writing and Classical Reading,” was conducted in a synchronous online manner. Through this process, the instructors shared the experiences, perceptions, and reflections that they discovered while practicing these writing classes in the changed educational environment. In addition, the instructors discussed the direction of synchronous online writing classes should take and the new issues required of them within this new environment.
Since the outbreak of COVID-19, a series of new studies have accumulated around the keyword “online class” from 2020 to the present, and these new discourses on education have led to various opinions and suggestions on how educational subjects should come up with educational countermeasures amid this pandemic. As a result of synthesizing these new data, I confirmed that instructors were paying attention to the difficulties of ‘interaction’ in the online environment. Therefore, in this study, the instructor's perceptions, reflections, and new practices experienced while operating the class were presented, with a focus on the changed educational environment and the resulting interaction patterns between instructors and learners.
As a result of this study, I was able to divide the instructor's perception and reflection into interactions in the technical environment, interactions pertaining to the learner's psychological aspect, and interactions regarding the instructor's practical aspect. In each of these interactions, the new practices attempted by the instructor could be summarized as “in-depth classroom practices,” practices for high context environments, “vivid voices” and relational communication environments, and “shared identities” and practices for the environment of practical knowledge.
In the future, many researchers will need to respond quickly to the changing trends of the times and share their experiences and opinions with other instructors involved in various educational subjects. At the same time, instructors will need to continue to implement new educational practices in their classrooms. Thus, I hope that this research paper contributes to this process in a beneficial and significant way.
Revealing the Needs of College Students Studying English in an Extracurricular Program
Authors: Kang Hyeonsook
Published: January 2022

This study examined the needs of various College students who are participating in an extracurricular program called “English Clinic.” In this program, students can ask questions about their English study and get help from English professors on an individual basis. The content of the questions was analyzed and compared according to both the majors and the years of the students. The most frequent questions asked by these students were those involving advice for preparing and planning for a public certification test, such as the TOEIC test. General study methods to improve their English skills and help with grammar learning were the second most frequently asked questions. Interestingly, there were quite a number of questions concerning the effectiveness of the study method regarding the course that they were currently taking. Their majors and years showed a difference in the frequency and content of each question category.
The study concluded that English Clinic should provide help of a more comprehensive nature, assisting the students not only by giving them writing feedback--which is all too common with such English Clinic programs―but by helping them with their very study process as well. Based on the results, this study makes suggestions regarding the development of certain programs and methods in order to better help those students who are in need of specific skills.
ADDITIONAL INSECT RECORDS FROM VENEZUELA
Authors: Martorell Luis F. , Escalona Salas Anselmo
Published: January 2022

Resumen en inglés.
TRANSLATION EQUIVALENCE OF INDONESIAN VERBREDUPLICATION INTO ENGLISH
Authors: DEWI NI PUTU AYU KARTIKA SARI
Published: January 2022

In terms of morphology, reduplication is called unique because it duplicates the similar words twice or more. In Indonesia, reduplication is often used in daily communication. It can make Indonesian language sound unique. It is possible to say “kecil-kecil” to emphasize “something (plural) in small size”. On the other hand, when Indonesian reduplication is translated into English, it is impossible to find “*small-small” as its translation. This paper aims to investigate about translation equivalence of Indonesian verb reduplication into English. The Natural Semantic Metalanguage approach proposed by Wierzbicka (1996) was used to find translation equivalence of Indonesian verb reduplication meaning and its translation into English. By using descriptive qualitative methods in analyzing data, the finding shows that verb reduplication emphasizes on reciprocal meaning, iterative meaning, and the meaning of doing something for happiness. Translating Indonesian verb reduplication into English means transferring the message or emphasizes meaning rather than preserving their unique form.

 

Keywords: Reduplication, Translation Equivalence, NSM Approach
PELATIHAN MC DAN PROTOKOL ACARA FORMAL DAN INFORMAL IBU-IBU PKK DI KECAMATAN PANTAI LABU
Authors: Iwanda Lubis Muya Syaroh , Nasution Asrindah , Hanum Azizah
Published: January 2022

Pengabdian dilakukan di Kecamatan Pantai Labu, dengan permasalahan yang sebelumnya salah seorang tim pengabdi sebagai ketua pelaksana pengabdian sudah pernah melakukan pelatihan Master of Ceremonies (MC) bagi ibu-ibu perwakilan desa pada waktu itu. Pihak kecamatan meminta kepada salah seorang tim pengabdi untuk memberikan pelatihan tentang bagaimana menjadi Master of Ceremonies (MC) yang baik dan benar. Karena waktu terlalu singkat, membuat penjelasan juga tidak efektif dan efisien. Hal inilah yang membuat tim melanjutkan pelatihan kembali. Berdasarkan pengamatan tim pengabdi, banyak dari mitra tidak mengetahui bagaiamana cara menjadi MC dan berbicara di depan publik. Pihak kecamatan juga mengatakan ketika ada acara di kecamatan, pihak mitra kesulitan dalam mencari orang untuk menjadi MC, karena ada beberapa alasan mereka yaitu : tidak berani, malu dan tidak percaya diri, sehingga ketika ada acara formal maupun non formal pihak kecamatan kesulitan mencari MC, hal inilah yang membuat tim pengabdi  ingin melakukan kembali pelatihan MC dan tambahan teknik protokol acara, setelah berdiskusi kembali dengan pihak kecamatan, fokus ditujukan kepada ibu-ibu PKK di kecamatan maupun yang terlibat dari  desa. Solusi dan target luaran kedepannya akan memudahkan mereka untuk memahami tentang MC, tata cara teknik protokol dengan benar. Menyelenggarakan pelatihan MC kepada ibu-ibu PKK di Kecamatan Pantai Labu. Sehingga ibu-ibu PKK yang sebelumnya kurang mengetahui manfaat pelatihan MC ini menjadi tahu, dan hal ini dapat menguntungkan bagi mereka, terutama secara finansial
PELATIHAN APLIKASI CORELDRAW DALAM PENINGKATAN HARDSKILL SISWA MENGHADAPI DUNIA KERJA
Authors: Yanto Robi , Kesuma Hendra Di , Alfiarini Alfiarini , Apriadi Deni , Etriyanti Endang
Published: January 2022

Kegiatan pengabdian masyarakat ini dilakukan di Sekolah Menengah Atas Negeri 2 Kota Lubuklinggau. Kegiatan ini meliputi pembelajaran desain grafis tentang pembuatan logo, spanduk dan banner yang diawali dengan pengenalan aplikasi coreldraw. Kegiatan ini bertujuan untuk meningkatkan hardskill siswa-siswa pada bidang desain grafis terutama pada siswa kelas XII yang akan menghadapi dunia kerja. Pembelajaran dilakukan pada kegiatan ini adalah bagaimana mendesain logo, spanduk dan banner yang dibutuhkan masyarakat sebagai properti media informasi yang banyak digunakan disetiap aktivitas baik industri, usaha dan perkantoran. Metode pembelajaran yang dilakukan adalah metode presentasi dan pendampingan langsung dalam bentuk praktikum penggunaan aplikasi coreldraw serta melakukan kegiatan evaluasi melalui penugasan studi kasus pembuatan logo, spanduk dan banner dengan tema hari ulang tahun RI yang ke 76. Berdasarkan hasil sebaran angket dan evaluasi kegiatan pelatihan keterampilan desain grafis menunjukan 83 % dari total peserta  bisa mendesain logo, spanduk, banner dan peserta dapat menerapkan lebih dari satu aplikasi desain grafis sehingga tujuan kegiatan pengabdian telah tercapai yaitu untuk meningkatkan hardskill peserta bidang desain grafis dalam menghadapi tantangan di dunia kerja.
PENINGKATAN PEMASARAN HASIL PRODUKSI MELALUI PELATIHAN INTERNET DAN MEDIA SOSIAL INSTAGRAM
Authors: Santiari Ni Putu Linda , Rahayuda I Gede Surya
Published: January 2022

Bali Kui merupakan kelompok usaha yang memproduksi anyaman dekorasi tradisional ramah lingkungan. Kelompok usaha ini berada di Desa Gulingan tepatnya di Banjar Lebah Sari Gulingan, Mengwi, Badung, Bali. Kelompok usaha ini dekat dengan obyek wisata Pura Taman Ayun. Dalam memasarkan hasil, Bali Kui masih menggunakan media pemasaran manual yaitu dari mulut ke mulut. Anggota kelompok usaha Bali Kui juga belum mengetahui internet dan media sosial. Dari 7 orang anggota yang ada dalam kelompok ini hanya 1 orang yang memiliki media sosial. Untuk itu dalam kegiatan program kemitraan masyarakat (PKM) ini akan dilakukan pelatihan pengenalan internet dan media sosial. Pelatihan dilakukan secara luring ke tempat mitra yaitu Bali Kui. Dengan pelatihan ini diharapkan dapat membantu kelompok usaha meningkatkan pengetahuannya dalam internet dan media sosial. Selain itu diharapkan kelompok usaha bisa menggunakan internet dan media sosial untuk memasarkan hasil dekorasi tradisional yang di produksi. Indikator capaian adalah mitra mengetahui dan bisa menggunakan internet dan media sosial. Dari pelatihan yang diberikan dan hasil evaluasi berupa kuisioner diperoleh total rata-rata nilai kuisioner 4 dengan persentase 80%. Dapat disimpulkan bahwa peserta pelatihan “Bisa” menggunakan dan memasarkan produk dengan instagram
KONTRIBUSI MULTIFAKTOR PADA PELATIHAN STRATEGI SELF-MANAGEMENT UNTUK MENGEMBANGKAN SIKAP AKTUALISASI DIRI GURU BIMBINGAN DAN KONSELING
Authors: Hartono Hartono , Mudhar Mudhar
Published: January 2022

Sikap aktualisasi diri guru bimbingan dan konseling merupakan aspek penting yang perlu dikembangkan dalam upaya mewujudkan pelayanan bimbingan dan konseling yang bermutu kepada peserta didik. Pengabdian kepada masyarakat ini bertujuan untuk mengetahui kontribusi multifaktor yaitu faktor penghargaan, pujian, dan suasana kerja terhadap pengembangan sikap aktualisasi diri guru bimbingan dan konseling setelah mengikuti program pengabdian kepada masyarakat. Metode pengabdian kepada masyarakat ini menggunakan model pelatihan strategi self-management yang dilaksanakan melalui tiga tahap yaitu tahap pertama pendalaman materi, tahap kedua simulasi, dan tahap ketiga pemberian tugas yang diikuti oleh peserta yaitu guru bimbingan dan konseling SMP dan SMA sederajat. Pada tahap pendalaman materi, peserta pengabdian menunjukkan perilaku aktif dalam mencermati materi yang dipresentasikan oleh narasumber melalui pertanyaan, tanggapan, dan argumentasi yang kritis. Pada tahap simulasi, secara kelompok peserta pengabdian melakukan praktik self-management pada konseling kelompok dan bimbingan kelompok yang teramati dan mendapatkan balikan dari narasumber. Sedangkan pada tahap penugasan, peserta pengabdian diberikan tugas untuk mengembangkan model verbatim praksis strategi self-management dalam konseling kelompok melalui google form. Setelah kegiatan selesai tim pengabdian melakukan evaluasi kepada peserta dengan menggunakan kuesioner melalui google form yang hasilnya menunjukkan bahwa kontribusi faktor penghargaan sebesar 80,26%, faktor pujian sebesar 83,66%, dan faktor suasana kerja sebesar 97,05% terhadap pengembangan sikap aktualisasi diri guru bimbingan dan konseling.
INOVASI PENGELOLAAN SAMPAH DESA CILEUYA YANG BERDAMPAK LANGSUNG SECARA LINGKUNGAN DAN KEUANGAN
Authors: Maulana Yasir , Masruroh Rina , Wachjuni Wachjuni , Pitriani Pitriani , Azzarri Bunga
Published: January 2022

Desa Cileuya merupakan salah satu desa yang berada di Kecamatan Cimahi, Kabupaten Kuningan. Desa Cileuya terdiri dari lima dusun, sembilan RW, dan empatpuluh RT. Jumlah penduduk sebanyak 5.320 jiwa dengan total 1.871 kepala keluarga 1.871. Masing-masing KK per hari rata-rata menghasilkan sampah 0,4 kg, sehingga sampah yang dihasilkan adalah 748 kg sampah per hari. Namun sampah tersebut belum terkelola dengan baik, masih dibuang sembarangan dan belum dimanfaatkan sama sekali, sehingga cenderung menyebabkan pencemaran lingkungan. Sehubungan dengan hal tersebut, maka dilakukan kegiatan pendampingan terutama kepada Desa Cileuya yang bertujuan untuk memperbaiki pengelolaan sampah desa. Pelaksanaan pendampingan dengan menggunakan metode workshop dan FGD. Hasil kegiatan pendampingan ini adalah pelatihan pengelolaan sampah, perencanaan pembangunan pengelolaan Tempat Pembuangan Akhir dan bank sampah
PENDAMPINGAN TRANSFORMASI ADMINISTRASI MELALUI APLIKASI MICROSOFT EXCEL PADA KSM WILO DESA KETANIRENG KECAMATAN PRIGEN PASURUAN
Authors: Riswandari Ninuk , Swasono Muh Aniar Hari
Published: January 2022

Kegiatan pengabdian masyarakat dengan metode blended learning dengan tema "DIGITALISASI SAMPAH" bertujuan untuk mempraktikkan ilmu pengetahuan, teknologi dan seni secara online dan offline akibat mewabahnya virus Covid-19. Kegiatan ini diharapkan dapat menjadi motivasi dan fasilitasi upaya pembangunan, terutama di daerah pedesaan. Masyarakat dapat berbagi permasalahan dan mencari solusi dengan partisipasi tim pengabdian masyarakat sehingga kerjasama terjalin dalam proses pembangunan di daerah setempat. Tujuan atau target yang diharapkan dapat dicapai adalah: (a) mengubah administrasi pengelolaan sampah dari manual menjadi digital. (b) mengetahui pengoperasian bank sampah; (c) mengetahui proses pengolahan limbah. Metode pelaksanaan kegiatan pengabdian masyarakat dilakukan dalam bentuk PAR (Participatory Action Research) serta  sosialisasi dan pelatihan dengan melibatkan masyarakat, pemerintah desa dan pengelola bank sampah secara langsung dan tidak langsung. Beberapa hasil yang dicapai dari kegiatan pengabdian masyarakat ini adalah sistem administrasi pengelolaan sampah menggunakan Microsoft Excel, dioperasikannya sistem bank sampah dan proses pengolahan limbah organik
THE DISLOCATION UNPINNING FROM STOPPERS IN KBr SINGLE CRYSTALS СAUSED BY ELASTIC STRESSES AND TEMPERATURE
Authors: Petchenko О.M. , Petchenko G.О. , Boiko S.M. , Litvinenko A.S. , Kоlyada O.Yu.
Published: January 2022

The impulse echo-method was applied to study, in the temperature range 300…435 K and at 7.5 MHz frequen-cy, the dislocation attenuation αd(σ) in KBr crystals as a function of static loading in the quasi-elastic strain range. It has been found that the temperature increase at stresses σ > σy (σy is the yield limit of a crystal) leads to the inten-sive dislocations’ unpinning. Consequently, concentration of stoppers, controlling their motion, sharply decreases and the effective length of oscillating dislocation segments increases. As a result of experimental data processing the energy of the impurity atom binding with dislocation U0 was calculated in the following work.
RADIATION-TERMOCATALYTIC PROCESSES FOR HYDROGEN PRODUCTION FROM WATER
Authors: Agayev T.N. , Melikova S.Z. , Hadzhiyeva H.F.
Published: January 2022

The radiation-thermal-catalytic processes of water decomposition in the n-ZrO2-n-Al2O3+H2O system are investigated. The kinetics of molecular hydrogen accumulation was studied during radiolytic processes of water decomposition in the systems under study. The values of the accumulation rates and radiation-chemical yields of hydrogen during the radiolysis of water in the n-ZrO2-n-Al2O3+H2O system at various temperatures have been determined. Besides this, it was shown that the results obtained serve as a base for checking the scenarios of normal and emergency conditions of nuclear reactors refrigerated by water.