bluuebunny/crossref_metadata_2025 huggingface dataset:
Online Integrative Community Therapy: Promoting mental health during the COVID-19 pandemic in Brazil
Authors: Reis Júlia Feldmann Uhry , Colatusso Franciele Delurdes , Barreto Adalberto de Paula , Reis Maria Lucia de Andrade , Giolo Suely Ruiz , Silva Milene Zanoni da , Pecharki Giovana Daniela
Published: January 2025

During the COVID-19 pandemic, psychological suffering was intensified due to the social isolation measures. This study aims to investigate the effects of Integrative Community Therapy (ICT) in the online modality as a strategy to promote mental health during the pandemic in Brazil. To this end, an intervention study of mixed design, observational and longitudinal, with a pre-test at T0 and a post-test at T1, was conducted in the virtual environment of ICT circles. The sample comprised 65 participants who answered three forms at T0 and T1 containing questions from five psychological measurement scales. The Wilcoxon paired-sample test was used to compare the scores recorded at T0 and T1 for such scales. Furthermore, content analysis was used to organize and extract meaning from the qualitative data collected in an online thematic ICT circle. Quantitative analyses showed a higher level of psychological well-being at T1, specifically for three dimensions: positive relations with others (p-value < 0.05), environmental mastery (p-value = 0.021), and purpose in life (p-value = 0.048). In addition, content analysis revealed a predominance of reports on positive relations with others. Overall, the present study suggested that, during the pandemic, online ICT has contributed to maintaining essential elements associated with individuals' mental health, such as close social relationships and meaning and purpose in life. Thus, given its low cost and accessibility, ICT emerges as a potential and innovative resource for promoting mental health in contexts of crisis and adversity.
PENGARUH AIR LAUT TERHADAP KUAT TEKAN BETON MUTU K-175
Authors: Wibowo Wibowo
Published: January 2025

Terjadinya instrusi air laut di wilayah Jakarta dan termasuk pula daerah Bekasi dan sekitarnya, makin lama mengkhawatirkan, dalam arti wilayah yang terkena instrusi air laut makin meluas. Untuk itu perlu diketahui dampak yang mungkin timbul akibat yang terjadi instrusi tersebut terutama pada beton. Dalam hal ini beton yang digunakan sebagai pondasi ataupun konstruksi lainnya yang berhubungan langsung dengan tanah maupun air tanah. Penelitian ini melihat seberapa besar pengaruh air laut pada kuat tekan beton normal. Metodologi Penelitian yaitu dengan melakukan serangkaian uji material sehingga dinyatakan memenuhi syarat, kemudian dilakukan pembuatan dan pencetakan benda uji dengan mutu beton K-175 dan kemudian dirawat dengan air laut dan air tawar sesuai umur rencana lalu diuji dengan Alat Uji Kuat Tekan beton. Hasil Pengujian menunjukkan Beton normal K-175 yang dirawat menggunakan air laut mengalami penurunan kuat tekan sebesar 1,18 % pada usia 3 hari, 1,05% pada usia 7 hari , 1,24% pada usia 14 hari, 1,1% pada usia 28 hari. Untuk beton yang menggunakan air laut sebagai campuran beton mengalami penurunan kuat tekan beton terhadap beton normal sebesar 8,1 % pada usia 3 hari dan 7,24 % pada usia 7 hari.
Kata Kunci: Air laut, Air tawar, Beton, Kuat Tekan, Agregat
ANALISIS DEFORMASI BALOK INDUK MESJID KAMPUS UNIVERSITAS ISLAM “45” BEKASI DENGAN METODE MATRIKS KEKAKUAN
Authors: Mardiana Mamar , Darma Eko
Published: January 2025

Retakan pada penampang balok sering kali menjadi permasalahan, mengingat vitalnya fungsi balok pada sebuah konstruksi struktur bangunan, sebagaimana yang terjadi pada balok induk mesjid Al Fatah kampus Universitas Islam “45” (Unisma) Bekasi.Secara visual retak rambut terjadi di seluruh penampang tinggi bentang balok, dalam hal ini retakan tersebut dapat dimasukan dalam kategori retak non struktural, yaitu retak – retak permukaan yang salah satu penyebabnya adalah pergerakan bekisting. Mengingat elemen – elemen arsitektural bangunan berupa kubah – kubah belum terpasang, upaya pun dilakukan dengan menempelkan plat baja pada bagian bawah penampang balok induk (system steel plat bonding) Dengan pemodelan numeric (SAP 2000) dan analitis metode matrik kekakuan, inersia (I) balok pun diteliti, yaitu dengan membuat model balok dengan asumsi penurunan presentasi dimensi balok dari dimensi balok utuh, dengan tujuan untuk mendapatkan model dimensi balok yang memiliki nilai inersia yang hampir menyerupai kondisi aktual balok dilapangan. Dari hasil analitis tersebut menunjukan bahwa kondisi inersia (i) balok induk mesjid Al Fatah adalah 415937.5 yaitu inersia dari dimensi balok 30x55cm, atau 70% dari dimensi kondisi utuh yaitu 35x80cm.
Kata Kunci: deformasi, lendutan
IDENTIFIKASI DAERAH RAWAN KECELAKAAN LALU LINTAS (BLACK SPOT AREA) BERBASIS SISTEM INFORMASI GEOGRAFIS
Authors: Wisudawati Deasy Anggraini , Sylviana Rika
Published: January 2025

Hampir seluruh kegiatan yang dilakukan membutuhkan sarana transportasi, jika sarana transportasi tidak berjalan dengan baik diakibatkan adanya kecelakaan lalu lintas maka kegiatan yang dilakukan tidak akan berjalan dengan baik. Untuk itu, maka dibuat sistem informasi yang dapat mendukung yaitu SIG (Sistem Informasi Geografis) untuk dapat memperoleh informasi mengenai daerah rawan kecelakaan sehingga dapat melakukan upaya-upaya untuk mengurangi dan mencegah kecelakaan. Data yang ditampilkan merupakan sebagian ruas jalan arteri dan kolektor yang ada di Kota Bekasi, yaitu berupa identifikasi daerah rawan kecelakaan secara visual, yang terdiri dari theme jalan dan ruas jalan , informasi tabel, grafik, dan foto. Berdasarkan data tahun 2007-2009, tingkat kecelakaan terus meningkat sebesar 48% dengan pertumbuhan rata-rata 400,67 per tahunnya. Lokasi kecelakaan yang memiliki bobot paling besar adalah pada jalan Siliwangi, dengan 61 kecelakaan dan bobot 426. Sedangkan severity index (indeks tingkat keparahan) terjadi pada jalan Perjuangan sebesar 0,409. Kendaraan yang mengalami kecelakaan adalah sepeda motor sebesar 60,223%. Pada identifikasi daerah yang rawan kecelakaan terdapat 9 jalan rawan dan 4 jalan tidak rawan.
Kata kunci: Daerah rawan kecelakaan, kecelakaan lalu lintas, SIG
Dichtung als Wissenschaft und Unterrichtsgegenstand
Authors: Feddern Stefan
Published: January 2025

Die Dichtung wurde im frühen italienischen Humanismus vor allem als Wissenschaft und Unterrichtsgegenstand beschrieben und verteidigt. Hierdurch erklärt sich die Fokussierung auf die rationalen Strukturen der Poesie. Etwas vereinfacht gesagt wurde im 14. Jahrhundert das Paradigma etabliert, dass die Dichter die Fiktion und die Allegorie als wissenschaftliche Instrumente verwenden, um die Wahrheit zu vermitteln.

Diese Prämisse liegt auch den pädagogisch-didaktischen Traktaten des 15. Jahrhunderts zugrunde. Diese behandeln aber das Erkenntnispotential (ebenso wie moralische Risiken) der paganen Poesie unter besonderer Berücksichtigung von didaktischen und rezeptionsästhetischen Gesichtspunkten. Diese Grundlagen der im Wesentlichen lateinischen poetologischen Diskussion der italienischen Frühhumanisten (von ca. 1350 bis ca. 1450) werden in diesem Buch erstmals systematisch aufgearbeitet.
Enrique Dussel’s concept of modernity: the intellectual evolution of a complex understanding of our age
Authors: Pimenta Tomás Lima
Published: January 2025

This paper examines Enrique Dussel’s concept of modernity by offering an intellectual reconstruction of the evolution of his thought and argues that his conception of modernity is not a reductionist idea of Eurocentrism and colonialism. It emphasizes his transdisciplinary approach, spanning from history, economic history, metaphysics, and ethics, providing a rich and unparalleled understanding of modernity. This perspective reveals crucial aspects of the genesis and essence of modernity, as well as key insights to interpret its current state and fate. For this purpose, Dussel’s intellectual trajectory is divided into different phases. For each period, it highlights his primary interlocutors, topics of investigation, and insights about the essence of modernity. In this context, this paper emphasizes the roles of economic history, World-System analysis, and geopolitics in his philosophical project. In short, it argues that Dussel’s theory of modernity operates as a geopolitical turn in philosophy.
A arte como instrumento de discursivização da memória e da resistência: o caso do Regime Militar no Brasil
Authors: Abreu-Aoki Raquel , Arcanjo Fábio Ávila
Published: January 2025

Este artigo examina a disputa pela memória durante a ditadura civil-militar brasileira (1964-1985), enfatizando a arte como instrumento de resistência. O problema principal é como artistas e intelectuais enfrentaram a censura e repressão, mantendo viva a memória dos que lutaram pela democracia. O objetivo é analisar a contribuição da arte, particularmente no documentário Cadê Heleny?, que retrata a trajetória da militante Heleny Guariba. A pesquisa justifica-se pela relevância de se preservar a memória coletiva. A metodologia adotada é a análise qualitativa de fragmentos significativos do documentário, articulando a relação entre política da memória e arte, evidenciando algumas potencialidades intrínsecas do cinema documentário. Os resultados evidenciam que a arte não só representou o protesto contra injustiças, mas moldou a consciência coletiva, contribuindo para os esforços de democratização e justiça no Brasil pós-ditadura. A abordagem explora o cinema documental como ferramenta de resistência, oferecendo uma narrativa alternativa à história oficial.
Pela estrada de tijolos amarelos: narrativa (auto)biográfica de um aprendiz de Geometria
Authors: Soares Gabriel de Oliveira , Leivas José Carlos Pinto
Published: January 2025

Inspirado pela jornada de Dorothy, em O Mágico de Oz, este trabalho tem por objetivo refletir, em uma perspectiva (auto)biográfica, a trajetória pessoal do primeiro autor acerca de suas aprendizagens relacionadas à Geometria e ao ensino desse tópico a partir da participação em um Grupo de Estudos em Geometria, estabelecendo, sempre que possível, relações com os Domínios do Conhecimento Matemático para o Ensino, propostos por Ball, Thames e Phelps (2008). Por meio da reflexão do vivenciado até então, busca-se estabelecer possíveis contribuições dessa participação na (re)construção de meu conhecimento, além de visitar reverberações dele ao longo de minha trajetória enquanto professor. Após as reflexões, é possível constatar que a participação em grupos de estudos pode promover, de fato, o desenvolvimento profissional de seus participantes, favorecendo a aprendizagem em um ambiente posterior à formação inicial.
A novel lossless encoding algorithm for data compression–genomics data as an exemplar
Authors: Al-okaily Anas , Tbakhi Abdelghani
Published: January 2025

Data compression is a challenging and increasingly important problem. As the amount of data generated daily continues to increase, efficient transmission and storage have never been more critical. In this study, a novel encoding algorithm is proposed, motivated by the compression of DNA data and associated characteristics. The proposed algorithm follows a divide-and-conquer approach by scanning the whole genome, classifying subsequences based on similarities in their content, and binning similar subsequences together. The data is then compressed into each bin independently. This approach is different than the currently known approaches: entropy, dictionary, predictive, or transform-based methods. Proof-of-concept performance was evaluated using a benchmark dataset with seventeen genomes ranging in size from kilobytes to gigabytes. The results showed a considerable improvement in the compression of each genome, preserving several megabytes compared to state-of-the-art tools. Moreover, the algorithm can be applied to the compression of other data types include mainly text, numbers, images, audio, and video which are being generated daily and unprecedentedly in massive volumes.
The differentiation state of small intestinal organoid models influences prediction of drug-induced toxicity
Authors: Klein Jessica A. , Heidmann Julia D. , Kiyota Tomomi , Fullerton Aaron , Homan Kimberly A. , Co Julia Y.
Published: January 2025

Drug-induced intestinal toxicity (GIT) is a frequent dose-limiting adverse event that can impact patient compliance and treatment outcomes. In vivo, there are proliferative and differentiated cell types critical to maintaining intestinal homeostasis. Traditional in vitro models using transformed cell lines do not capture this cellular complexity, and often fail to predict intestinal toxicity. Primary tissue-derived intestinal organoids, on the other hand, are a scalable Complex in vitro Model (CIVM) that recapitulates major intestinal cell lineages and function. Intestinal organoid toxicity assays have been shown to correlate with clinical incidence of drug-induced diarrhea, however existing studies do not consider how differentiation state of the organoids impacts assay readouts and predictivity. We employed distinct proliferative and differentiated organoid models of the small intestine to assess whether differentiation state alone can alter toxicity responses to small molecule compounds in cell viability assays. In doing so, we identified several examples of small molecules which elicit differential toxicity in proliferative and differentiated organoid models. This proof of concept highlights the need to consider which cell types are present in CIVMs, their differentiation state, and how this alters interpretation of toxicity assays.
Index-based livestock insurance schemes to manage climate risks in Ethiopia: determinants of farmer’s willingness to pay and lessons learned from Dasenech district, South Omo
Authors: Melketo Tagesse , Tolossa Degefa , Abi Meskerem , Bedeke Sisay , Fentaw Tenaw
Published: January 2025

Livestock insurance, an important risk management tool, is gaining popularity in Ethiopia. Proper investigation is needed to expand its adaptability throughout the country. This study was designed to explore the willingness and payment capacity of farmers in Southern Ethiopia to pay for index-based livestock insurance as an alternative solution to climate risk mitigation. A mixed research method was employed to gather data from primary and secondary sources. Cross-sectional data were obtained from 157 cattle farmers, drawn randomly from the study area. The study also used key informant interviews and focus group discussions to collect qualitative data. Descriptive statistics, inferential tests, and double-hurdle model were used to analyze quantitative data. Word descriptions and thematic analysis were employed for qualitative data analysis. The results of the study showed that a significant proportion of farmers were willing to pay for IBLI services. The findings also suggested that the demand for index-based livestock insurance seemed to be influenced by a number of factors. Those households that are headed by a men, who are better educated, who are better experienced in farming system, and those who have access to credit and training are more likely to pay for the insurance. Farmers’ perception of weather-related risks and awareness about insurance also influenced farmers’ willingness to pay positively. Furthermore, farmers with larger assets, such as land and livestock, have more confidence in paying capacity for insurance. Farmers with mass media access were more likely to pay for IBLI. However, households with larger number of household members and those who perceived the cost of the insurance premium as unaffordable are less likely to purchase the IBLI. These significant factors impacting households’ willingness to pay for the insurance services must be considered in adaptation pathways. The Dasenech district case study suggests that IBLI can effectively mitigate climate risks and be applied to other regions with similar socioeconomic characteristics and production systems.
Culturally appropriate terminologies in health research: a participatory study with pregnant and breastfeeding mothers in Uganda
Authors: Nakijoba Ritah , Twimukye Adelline , Bayigga Josephine , Kawuma Aida N. , Asiimwe Simon Peter , Byenume Fredrick , Kyeyune Jacqueline , Nabukenya Sylvia , Ojara Francis Williams , Waitt Catriona
Published: January 2025

Background

The language used in research and health programs is crucial in influencing participation and ensuring the acceptability of programs and the adoption of research outcomes. The use of alienating language may present a barrier for research participants hence the need to identify accurate, respectful, relevant, and acceptable terms for respective study populations. The study explored commonly used terminologies during research involving pregnant and lactating mothers using public engagement and participatory approaches in Uganda.

Methods

A cross-sectional qualitative study was conducted in August 2023 among 5 ethnically diverse communities with different languages and from different regions across Uganda. Data were collected through 18 focus group discussions (FGDs) comprising community members and one comprising the community advisory board (CAB) using a participatory approach. An interview guide exploring perceptions and experiences on research, common and preferred terms for specific terminologies used among pregnant and lactating mothers as well as disliked words guided the discussion. Transcription was done verbatim in English. Nvivo version 14 software was used to organize and manage the data appropriately based on themes and subthemes.

Results

A consensus on the preferred terminologies to communicate about our research studies involving pregnant and lactating mothers was reached. The study revealed that words used in research that did not specify sex were described as disrespectful, inappropriate or confusing. Language defining a person on the basis of anatomical or physiological characteristics was considered ‘embarrassing’ and labelling individuals based on their conditions was construed as stigmatising. Participants recommended that researchers be mindful of any terms that could be perceived as embarrassing or inappropriate within the community, ensure clear communication of research terms to participants, and train healthcare workers on the use of appropriate health language. The importance of providing feedback regarding study findings was emphasised.

Conclusion

The findings highlight the importance of using culturally sensitive language in health research to improve engagement and participation. By adopting community-preferred terms, researchers can avoid confusion and stigma fostering respectful health communication. The findings offer guidance for future research, advocating for community-driven inclusive language in research involving pregnant and breastfeeding women. For healthcare workers, training in empathetic communication and cultural competence is crucial to improve patient interactions and promote dignity in healthcare settings.
The impact of pre-transplant ventricular assist device support in pediatric patients with end-stage heart failure on the outcomes of heart transplantation—“a single center experience”
Authors: Rosenthal L. Lily , Grinninger Carola , Ulrich Sarah Marie , Dalla Pozza Robert , Haas Nikolaus A. , Brenner Paolo , Schmoeckel Michael , Michel Sebastian , Hagl Christian , Hörer Jürgen
Published: January 2025

Introduction

The objective of this study was to examine the impact of ventricular assist device support as a bridge to heart transplantation in children with end-stage heart failure. In light of the limited availability of donor organs, particularly in Europe, the number of children requiring ventricular assist device support is rising at an unavoidable rate.

Methods

We performed a retrospective cohort study of patients who underwent a single and primary pediatric heart transplantation. Patients were divided into two groups: with pre transplant ventricular assist device (VAD) support and without VAD support. The primary outcome was survival at the follow-up evaluation. The time point designated as “time 0” was defined as the time of heart transplantation. Secondary outcome was examined by mean of univariable and multivariable logistic regression, severity of cardiac disease based on ECMO-support pre VAD-support, mean waiting time for transplantation, mean OR time and mean length of hospital stay before and after transplantation.

Results

144 patients could be included in the final analysis. The cumulative survival rate at follow-up period was 67 ± 10% in group 1 vs. 60 ± 6% in group 2 (P = 0.769). The mean waiting time (days) on the list was 205 ± 155 in group 1 and 119 ± 69 in group 2 (P = 0.002). The mean length of hospital stay (days) was 214 ± 209 in group 1 and 128 ± 91 days in group 2. Early primary-graft-failure was 10% in group 1 and 13% in group 2. Odds ratio [OR] is as follows: 1.992, 95% confidence interval [CI]: 0.983–1.007, p = 0.266, aortic clamp time per minutes: OR: 1.008, 95% CI: (0.997–1.019), p = 0.164, HLM time per minutes: OR: 0.996, 95% CI: (0.991–1.001), p = 0.146, Operation time per minutes: OR: 1.000, 95% CI: (0.995–1.004), p = 0.861.

Conclusion

The provision of pre-HTx VAD support does not have an adverse effect on the short- and long-term survival of pediatric patients undergoing HTx. A higher mortality rate was observed among children under three months of age with congenital heart disease. The patients who received VAD support were in a critical condition and required more ECMO support. The results demonstrated a statistically significant correlation between prolonged waiting times and length of hospital stay in group 1. More homogeneous and adequately powered cohorts are needed to better understand the impact of VAD support on posttransplant outcomes.
The Neoproterozoic Ediacaran Kaijiang-Xuanhan paleo-uplift in the Sichuan Basin, Western China
Authors: Guo Ran , Li Zeqi , Wu Jianxue , Liu Shugen , Sun Wei , Wang Peng , Deng Bin , You Liwei , Liu Zhiyi
Published: January 2025

The structural characteristics and formation evolution of the Sinian Kaijiang-Xuanhan paleo-uplift play a foundational role in the formation and evolution of the Sichuan Basin. To comprehensively understand the structural characteristics and formation evolution of the Sinian Kaijiang-Xuanhan paleo-uplift, this paper, based on geological, logging, seismic, and drilling, further confirms the existence of the Sinian Kaijiang-Xuanhan paleo-uplift and provides a detailed study of its characteristics. The entire Ediacaran tectonic sedimentary framework of the Sichuan Basin was controlled by this northeast-trending paleouplifted area. The Dengying Formation in the Kaijiang-Xuanhan region and the Mianyang-Anyue-Changning region both exhibit a thinning trend, but the genetic mechanisms are different. The thinning in the former is the result of sedimentary control during the early stages of paleouplift, with the lower parts of the first and second stages being absent; in the latter region, this is due to subsequent erosion. During the deposition periods of the Doushantuo and Dengying formations, the Sichuan Basin was predominantly in a weak compressional state, forming the Kaijiang-Xuanhan paleo-uplift, with the main structural orientation being northeastward. By the late Dengying Formation and early Cambrian, the region experienced a weak extensional state, resulting in the development of the Mianyang-Changning rift, with the main structural orientation being north-northwestward. The Kaijiang-Xuanhan paleo-uplift underwent four stages: the incubation period (before the deposition of the Doushantuo Formation), the peak development period (during the deposition of the Doushantuo Formation), the decline period (during the deposition of the Dengying Formation), and the extinction period (during the Lower Cambrian deposition). The further confirmation and in-depth study of the Sinian Kaijiang-Xuanhan paleo-uplift enhances the understanding of the Neoproterozoic craton of the Sichuan Basin and enriches the theory of the formation and evolution of the Sichuan Basin.
Research on blow-out of shield tunnel in sandy soil with shallow burial
Authors: Shi Yong-Xiang , Xi Bao-Ping , Di Qi-Guang , Wang Feng-Nian
Published: January 2025

Because of its non-viscosity, sand layer is easy to cause rock instability, which is always a difficult problem in tunnel excavation.This study employs an integrated approach of numerical simulation and theoretical analysis to investigate the phenomenon of shield tunnel faces blow-out in shallowly buried sandy soil strata. The research study the effects of burial depth to diameter ratio and the angle of internal friction on the ultimate support pressure and the shape of the failure zone. According to the simulation results, an analytical model for the blow-out of tunnel faces has been developed. The study reveals a linear relationship between the passive ultimate support pressure and the burial depth ratio, as well as the tangent of the friction angle. Upon tunnel passive failure, the failure zone is composed of a rigid core in the form of a lower wedge shape and an upper passive zone in the form of an inclined cylinder. Furthermore, using the wedge shape and inclined cylinder model and applying the theory of limit analysis, the corresponding formula for the ultimate support pressure has been derived. Compared to existing numerical models and classical analytical models, the analytical solution proposed in this paper is more accurate. The research on the failure zone found that an increase in the friction angle causes an enlargement of the failure zone and an increase in the dissipated power at the boundary, resulting in an exponential growth of the limit support pressure. The cohesion has a minimal effect on the shape and area of the failure zone, primarily manifesting as an increase in the dissipated power at the failure zone boundary. Additionally, the burial depth ratio has an insignificant effect on the lower failure zone, but as the cover ratio increases, the area of the upper failure zone gradually expands. At a smaller cover ratio, the weight of the soil plays a dominant role, whereas at a larger cover ratio, the effects of frictional force and cohesion at the failure zone boundary become more pronounced.
Correlation between Chinese visceral adiposity index and serum uric acid levels in type 2 diabetes mellitus patients
Authors: Araújo Intchasso Adotey Swailla Amina , Zhang Qian , Chen Mengxue , Jiao Yang , Zhang Yin , Butoyi Claudette , Wang Dong , Yang Ling , Yuan Guoyue , Jia Jue
Published: January 2025

Purpose

The Chinese Visceral Adiposity Index (CVAI), a measure of visceral adiposity dysfunction, is used to assess visceral fat (VFA) malfunction. This research was performed to evaluate the relationship between CVAI and serum uric acid levels in type 2 diabetes mellitus (T2DM) patients.

Methods

A total of 2268 patients with T2DM were enrolled in this study. We collected the general clinical information of patients, measured the basic anthropometric indicators, tested glycolipid metabolism and biochemical indicators, and measured the visceral and subcutaneous fat area with bioelectrical impedance technology. According to the quartiles of the CVAI, the T2DM patients were classified into four groups: group A (CVAI ≤ 94.43), group B (94.43<CVAI ≤ 118.75), group C (118.75<CVAI ≤ 143.95), and group D (CVAI≥143.95), each group has 567 participants. Participants were divided into hyperuricemia (HUA) and non-HUA groups, and the clinical data between the two groups was compared.

Results

Among quartiles of CVAI, as CVAI increased, the proportion of patients with HUA gradually increased. The correlation analysis showed that the majority of basal measures, glycolipid metabolism and biochemical indicators were positively correlated with CVAI. By comparison, the level of CVAI in the HUA group was significantly higher than non-HUA group. Meanwhile, through using the ROC curve, our study observed the more predictive value of CVAI than other obesity indicators for T2DM with HUA.

Conclusion

CVAI is a simple but effective indicator, which is significantly correlated with HUA in T2DM and can reflect the incidence of HUA in T2DM patients. As CVAI increased, the risk of HUA in T2DM patients increased. Therefore, we should pay more attention to the application of CVAI in T2DM.
The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
Authors: Zhang Hui , Chen Minghui , Sun Lijie , Zhu Wenwen , Niu Tong , Fareeduddin Mohammmed Farooqui Huzaifa , Wang Hongxiao , Song Bing , Wang Jumei , Zhang Haoqiang
Published: January 2025

Aim

This study aims to investigate the role of activated partial thrombin time (APTT) as a potential mediator in the relationship between suboptimal glycemic control and diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes mellitus (T2DM).

Methods

A total of 183 T2DM patients were enrolled in this study. Comprehensive clinical data, including coagulation parameters and nerve conduction velocity, were collected and compared between patients with and without DPN. Subsequent correlation and regression analyses were conducted to explore the associations among APTT, HbA1c levels, and nerve conduction velocities. Moreover, mediation analyses were performed to evaluate the total, direct, and indirect effects of HbA1c on specific nerve conduction velocities, with APTT serving as a mediator.

Results

In comparison to 101 patients without DPN, 82 patients with DPN exhibited significantly elevated levels of HbA1c and decreased levels of APTT. Notably, levels of APTT and HbA1c were correlated with conduction velocities of Tibial nerve motor fibers, as well as sensory fibers of the Ulnar nerve, Median nerve, and Sural nerve. Furthermore, both elevated HbA1c and decreased APTT were identified as risk factors for DPN in T2DM individuals. Mediation analysis showed that APTT mediated the indirect effect of HbA1c on the conduction velocities of sensory fibers in both the ulnar nerve and sural nerve (95% CI: -0.3448, -0.0135; -0.3523, -0.0180). APTT mediated the relationship between HbA1c and the conduction velocities of sensory fibers in the ulnar nerve or sural nerve by 34.66% or 22.03%, respectively.

Conclusions

In patients with T2DM, uncontrolled HbA1c and shorter APTT emerges as risk factors for DPN. Additionally, the effect of increased HbA1c upon DPN, especially for influenced conduction velocities of sensory fibers in both the ulnar nerve and sural nerve may partly medicated by decreased APTT.
Optimization of ocean thermal energy conversion based on pressure energy recovery of ammonia water working medium
Authors: Tian Mingqian , Yu Yanni , Hou Yunxing , Chen Yun , Zhang Li , Liu Yanjun
Published: January 2025

Ocean thermal energy conversion is a new energy technology that utilizes the temperature difference conditions of seawater to generate electricity. This paper focuses on the closed cycle of ocean thermal energy conversion using ammonia as the working fluid. Based on pressure energy utilization devices such as pressure exchangers, hydraulic turbines, and ejectors, three methods are proposed to recover and utilize the pressure energy of the lean ammonia solution, in order to improve the thermal efficiency and systematic performance. By analyzing and comparing the performance of the cycle, it can be concluded that all three methods can achieve a utilization of pressure energy, and under the same conditions, the highest thermal efficiency of the ejector cycle is 5.71%.
Transgenerational epigenetic heritability for growth, body composition, and reproductive traits in Landrace pigs
Authors: Araujo Andre C. , Johnson Jay S. , Graham Jason R. , Howard Jeremy , Huang Yijian , Oliveira Hinayah R. , Brito Luiz F.
Published: January 2025

Epigenetics is an important source of variation in complex traits that is not due to changes in DNA sequences, and is dependent on the environment the individuals are exposed to. Therefore, we aimed to estimate transgenerational epigenetic heritability, percentage of resetting epigenetic marks, genetic parameters, and predicting breeding values using genetic and epigenetic models for growth, body composition, and reproductive traits in Landrace pigs using routinely recorded datasets. Birth and weaning weight, backfat thickness, total number of piglets born, and number of piglets born alive (BW, WW, BF, TNB, and NBA, respectively) were investigated. Models including epigenetic effects had a similar or better fit than solely genetic models. Including genomic information in epigenetic models resulted in large changes in the variance component estimates. Transgenerational epigenetic heritability estimates ranged between 0.042 (NBA) to 0.336 (BF). The reset coefficient estimates for epigenetic marks were between 80% and 90%. Heritability estimates for the direct additive and maternal genetic effects ranged between 0.040 (BW) to 0.502 (BF) and 0.034 (BF) to 0.134 (BW), respectively. Repeatability of the reproductive traits ranged between 0.098 (NBA) to 0.148 (TNB). Prediction accuracies, bias, and dispersion of breeding values ranged between 0.199 (BW) to 0.443 (BF), −0.080 (WW) to 0.034 (NBA), and −0.134 (WW) to 0.131 (TNB), respectively, with no substantial differences between genetic and epigenetic models. Transgenerational epigenetic heritability estimates are moderate for growth and body composition and low for reproductive traits in North American Landrace pigs. Fitting epigenetic effects in genetic models did not impact the prediction of breeding values.
Urinary human papillomavirus DNA as an indicator of gynaecological infection in young women in Schistosoma and HIV endemic South Africa
Authors: Pillay P. , Galappaththi-Arachchige H. N. , Taylor M. , Roald B. , Kjetland E. F.
Published: January 2025

Background

Globally, Africa has the highest HIV, cervical cancer and schistosomiasis prevalence. Female Genital Schistosomiasis (FGS) is hypothesized to be associated with HIV and cervical atypia. Young women aged 15 and above, constituting almost 3 million of the South African population, have limited health care access and are at risk for this triad of diseases. Urinary HPV DNA analysis is a non-invasive sampling method that can assist in evaluating risk among this population. This study compared the analysis of HPV DNA in urine and cervico-vaginal lavage (CVL) samples to cytology Pap smear, Schistosoma microscopy and HIV results.

Methods

In this cross-sectional study, 235 young women aged 16 years and older from rural high schools in KwaZulu-Natal participated. HPV DNA analysis was done in urine and CVL samples. Pap smears were analysed for squamous cell atypia and urine microscopy was used for the identification of Schistosoma ova.

Results

Urinary schistosomiasis was reported in 49 (20.9%) and HIV detected in 49 (20.4%). Urinary and CVL HPV DNA was found in 147 (62.6%) and 177 (75.3%) respectively. Any atypia was detected cytologically among 173 (73.6%). The following associations were found using the Pearson Chi-Square and a Likelihood Ratio test: (a) between HIV positive status and urinary HPV DNA positive cases on both the urine (X2 = 5.007; p-value = 0.025) and (X2 = 4.264; p-value = 0.039) and between HIV positive status and CVL HPV DNA tests respectively (X2 = 5.165; p-value = 0.023) and (X2 = 4.321; p-value = 0.015), and (b) among urine HPV DNA and the CVL HPV DNA tests, where (X2 = 52.966; p-value = 0.001) and (X2 = 50.716; p-value = 0.001). Urine HPV DNA showed a sensitivity of 75.7% and specificity of 77.6% relative to the CVL HPV DNA. There was no statistical association between urinary schistosomiasis and HPV or with any atypia.

Conclusion

Urine has the potential of being optimized as an alternative and possibly more acceptable sample for HPV detection among young adolescent populations at risk in comparison to CVL samples. An integrated targeted intervention incorporating Schistosoma in addition to HPV and HIV testing needs consideration among young women in this age group from endemic areas.
Respectful maternity care and associated factors among mothers who gave birth at public health institutions in Debre Tabor town, Northwest Ethiopia: a mixed-methods study
Authors: Fentie Tadesse Ayana , Solomon Abayneh Aklilu , Enyew Mihretu Molla , Beyene Meseret Mekuriaw , Melese Ayalew Kassie , Belay Alamirew Enyew , Alemu Gebrie Getu
Published: January 2025

Background

Respectful maternity care is care organized for and provided to all women in a manner that maintains their dignity, privacy, and confidentiality, ensures freedom from harm and mistreatment, and enables informed choice and continuous support during labor and childbirth. However, in many healthcare settings in Ethiopia, the standard practice of respectful obstetric care is not the norm, and a significant proportion of health professionals view patients merely as cases and do not show compassion.

Objectives

To assess respectful maternity care and associated factors among mothers who gave birth at public health institutions in Debre Tabor town, Northwest Ethiopia from December 1, 2023, to January 30, 2024.

Methods

An institution-based cross-sectional study was conducted using qualitative and quantitative data collection methods. Three hundred seventy participants were selected for quantitative analysis using systematic random sampling, while eight were chosen for the qualitative study through purposive sampling. The quantitative data were coded and entered into Epi Data version 4.6, then exported to the Statistical Package for the Social Sciences (SPSS) version 25 for analysis. A multivariable logistic regression analysis was performed to identify factors associated with the outcome variable. Adjusted odds ratios with 95% confidence intervals were computed to determine the significance level. Thematic analysis was used for the qualitative data.

Results

The proportion of respectful maternity care was 34.1% (95%CI: 29.4, 39.2) cesarean delivery [AOR = 3.45, 95%CI: 1.60, 7.42]. Daytime delivery [AOR = 3.14, 95%CI: (1.59, 6.18)] and less than or equal to 1 day stay in a healthcare facility [AOR = 3.03, 95%CI: (1.51, 6.08)] were positively associated with respectful maternity care. Inadequate equipment and supplies, shortage of staffing, and lack of accountability were barriers to providing respectful maternity care.

Conclusions

The proportion of respectful maternity care was low. Therefore, health institutions and other stakeholders should support and strengthen monitoring and evaluation mechanisms for maternal and neonatal healthcare providers and enhance education and constant support for women during their pregnancy and childbirth. Additionally, adequate access to basic equipment and supplies should be given due attention to ensure respectful maternity care.
Lipoxin A4 levels correlate with severity in a Spanish COVID-19 cohort: potential use of endogenous pro-resolving mediators as biomarkers
Authors: Sánchez-García Sergio , Jaén Rafael I. , Lozano-Rodríguez Roberto , Avendaño-Ortiz José , Pascual‐Iglesias Alejandro , Hurtado-Navarro Laura , López-Collazo Eduardo , Boscá Lisardo , Prieto Patricia
Published: January 2025

Background

SARS-CoV-2, the causative virus of the COVID-19 global pandemic, leads to a wide variety of responses among patients. Some of them present a very severe phenotype, while others only experience mild symptoms or are even asymptomatic. This differential prognosis is tightly related to the inflammatory status of the patient. Although WHO declared the end of the emergency, the pandemic caused a great socio-sanitary impact in all countries. Thus, the possible outbreak of new biological diseases in the future makes it necessary to deepen the knowledge of this uncontrolled immune response and look for reliable biomarkers to help us predict its potential health impact. Specialized pro-resolving lipid mediators (SPMs) as lipoxins are endogenous mediators synthesized from arachidonic acid in the resolution stage of any inflammatory process. These lipids have pro-resolving actions in several pathological models, including reducing NF-κB-mediated inflammation, and inducing the antioxidant response through the Nrf-2 pathway. Thus, although a potential relationship has already been suggested between low levels of SPMs and COVID-19 severity, their true role as a predictive biomarker is still unknown.

Methods and results

In this study, we have analyzed by ELISA the serum levels of lipoxin A4 (LXA4) in a representative Spanish cohort. We found reduced levels in deceased patients when compared to mild or severe patients, concomitant with a decrease in the LXA4 biosynthetic pathway and an increase in its degradation pathway. Furthermore, we have studied the correlation between the levels of this SPM and several pathology indicators, finding a significant correlation between increased LXA4 levels and a better prognosis of the patients.

Conclusion

We propose to measure systemic LXA4 as a new promising biomarker to predict the survival in patients affected by SARS-CoV-2 and presumably to other viruses that can affect humanity in the future.
Epithelial and immune transcriptomic characteristics and possible regulatory mechanisms in asthma exacerbation: insights from integrated studies
Authors: Liu Ye , Li Yue , Wu Ruhao , Wang Yu , Li Pengfei , Jiang Tianci , Wang Ke , Liu Yize , Cheng Zhe
Published: January 2025

Background

Asthma exacerbation significantly contribute to disease mortality and result in heightened health care expenditures. This study was aimed at gaining important new insights into the heterogeneity of epithelial and immune cells and elucidating key regulatory genes involved in the pathogenesis of asthma exacerbation.

Methods

Functional enrichment, pseudotime, metabolism and cell-cell communication analyses of epithelial cells and immune cells in single-cell RNA sequencing (scRNA-seq) dataset were applied. Immune infiltration analysis was performed in bulk RNA sequencing (bulk RNA-seq) dataset. Key regulatory genes were obtained by taking the intersection of the differentially expressed genes (DEGs) between control and asthma group in epithelial cells, immune cells and bulk RNA-seq data. Asthma animal and in vitro cell line models were established to verify the key regulatory genes expression by employing quantitative reverse transcription polymerase chain reaction (qRT-PCR).

Results

ScRNA-seq analysis identified 7 epithelial subpopulations and 14 distinct immune cell types based on gene expression profiles. Further analysis demonstrated that these cells manifested high heterogeneity at the levels of functional variations, dynamics, communication patterns and metabolic changes. Notably, TMPRSS11A, TUBA1A, SCEL, ICAM4, TMPRSS11B, IGFBP2, CLC, NFAM1 and F13A1 were identified as key regulatory genes of asthma. The results of the qRT-PCR demonstrated that the 9 key regulatory genes were involved in asthma.

Conclusions

We systematically explored epithelial and immune characteristics in asthma exacerbation and identified 9 key regulatory genes underlying asthma occurrence and progression, which may be valuable for providing new insights into the cellular and molecular mechanisms driving asthma exacerbations.
Tracing the origins and transformations of fluorescence dissolved organic matter within western and eastern Greenland’s shelves: a comparative study
Authors: Zabłocka Monika , Kowalczuk Piotr , Stoń-Egiert Joanna , Terzić Elena , Bournaka Evanthia , Palacz Artur P.
Published: January 2025

Differences in the composition and spatial distribution of Fluorescent Dissolved Organic Matter (FDOM) between western and eastern Greenland shelf waters reflect the interplay of distinct regional environmental drivers-such as glacial meltwater inputs and stratification effects – which shape local DOM processing and biogeochemical cycles. These contrasts provide unique opportunity to understand how Arctic coastal system responds to climatic changes. To investigate these dynamics, we assessed FDOM by an application of multivariate statistical method - Parallel Factor Analysis (PARAFAC) on samples collected in July 2021 and August 2022. The PARAFAC enabled the distinction of five components representing both humic-like (C1 (λEx/λEm 318/392), C2 (λEx/λEm 363(261)/445), C5 (λEx/λEm 399/513)) and protein-like (C3 (tyrosine) − λEx/λEm 267/305, (C4 (tryptophan) − λEx/λEm 285/345)) substances, showing variations between western and eastern shelves and across different water layers (surface, deep chlorophyll a maximum depth – DCM, and below it (i.e., in the West Slope Greenland Core water – WSGC, and in the core Polar Water - PW). The analysis showed that western DOM is almost equally composed of humic-like (51%) and protein-like (49%) substances, while the eastern shelf is dominated by protein-like FDOM (56%), indicating a stronger influence of autochthonous production in the east. The highest fluorescence intensity was measured of the protein-like component C3 in both eastern (PW layer) and western (DCM layer) shelves. In the surface waters of the western Greenland shelf we found a statistically significant (p<0.001), although relatively weak (R = 0.27) correlation between Ip and the total chlorophyll a concentration, Tchla. Derived values of spectral indices (HIX, BIX, and FI), and a ratio of fluorescence intensities of protein-like components to fluorescence intensities of humic-like components, Ip/Ih, indicated that the FDOM in analyzed water was predominantly autochthonous, characterized with low molecular weight and low-saturation aromatic rings. This findings provide new insights into FDOM composition in the Arctic under changing climatic conditions.
Body donor reperfusion and re-ventilation in medical training: an Italian study testing SimLife®
Authors: Neri Irene , Vara Giulio , Fazio Antonietta , Marvi Maria Vittoria , Koufi Foteini-Dionysia , Boschetti Elisa , Lodi Simone , Mariani Giulia Adalgisa , Quaranta Marilisa , Billi Anna Maria , Ruggeri Alessandra , Barausse Carlo , Brèque Cyril , Plava Annalisa , Moretti Veronica , Manzoli Lucia , Ratti Stefano
Published: January 2025

Background

Medical simulations have emerged as a valuable tool in anatomical-medical training, allowing healthcare professionals to gain hands-on experience in a controlled and safe environment. One such simulation platform is SimLife®, which uses the Pulse for Practice (P4P) system to enable realistic restoration of airflow (“re-ventilation”) and blood flow (“revascularization”) in bodies donated to science.

Objective

This study aimed to evaluate the feasibility of introducing SimLife® technology in Italy. Additionally, it assessed the impact of this technology across various medical specialties, utilizing a minimal number of donated bodies.

Methods

The study utilized the existing body donation program and dissection rooms at the Anatomy Center of the University of Bologna. 62 participants from 13 medical specialties performed simulations using the SimLife® P4P platform. Post-simulation, structured interviews were used to collect data on the interventions performed, participant perceptions of the technology’s usefulness, enjoyment, and willingness to repeat the experience, as well as critical issues encountered.

Results

Key findings include that 86% of participants rated SimLife® technology as extremely useful for post-lauream training, while 84% found it highly beneficial for team-building activities. A total of 31 interventions were successfully performed across various anatomical regions, with participants reporting high satisfaction and a strong willingness to repeat the simulation experience.

Conclusion

The findings support the effectiveness of SimLife® technology for body donor re-ventilation and revascularization, reinforcing its value for medical training across various specialties.