bluuebunny/crossref_metadata_2025 huggingface dataset:
ADAR1-regulated cytoplasmic dsRNA-sensing pathway is a novel mechanism of lenalidomide resistance in multiple myeloma
Authors: Koh Mun Yee , Chung Tae-Hoon , Tang Nicole Xin Ning , Toh Sabrina Hui Min , Zhou Jianbiao , Tan Tze King , Chen Leilei , Chng Wee Joo , Teoh Phaik Ju
Published: December 2024

Immunomodulatory agents (IMiDs) are a major class of drugs for treating multiple myeloma (MM); however, acquired resistance to IMiDs remains a significant clinical challenge. While alterations in cereblon (CRBN) and its pathway are known to contribute to IMiD resistance, they account for only 20-30% of cases, and the underlying mechanisms in the majority of the resistance cases remain unclear. Here, we identified ADAR1 as a novel driver of lenalidomide resistance in MM. We showed that lenalidomide activates the MDA5-mediated dsRNA-sensing pathway in MM cells, leading to interferon (IFN)-mediated apoptosis, with ADAR1 as the key regulator. Mechanistically, ADAR1 loss increased lenalidomide sensitivity through endogenous dsRNA accumulation, which in turn triggered dsRNA-sensing pathways and enhanced IFN responses. Conversely, ADAR1 overexpression reduced lenalidomide sensitivity, attributed to increased RNA editing frequency, reduced dsRNA accumulation and suppression of the dsRNA-sensing pathways. In summary, we report the involvement of ADAR1-regulated dsRNA-sensing in modulating lenalidomide sensitivity in MM. These findings highlight a novel RNA-related mechanism underlying lenalidomide resistance and underscore the potential of targeting ADAR1 as a novel therapeutic strategy.
Efficacy and Safety of Venetoclax Plus Azacitidine for Patients With Treatment-Naive High-Risk Myelodysplastic Syndromes
Authors: Garcia Jacqueline S. , Platzbecker Uwe , Odenike Olatoyosi , Fleming Shaun A , Fong Chun Yew , Borate Uma , Jacoby Meagan A , Nowak Daniel , Baer Maria R , Peterlin Pierre , Chyla Brenda , Wang Huipei , Ku Grace , Hoffman David , Potluri Jalaja , Garcia-Manero Guillermo
Published: December 2024

Patients with higher-risk myelodysplastic syndromes (HR MDS) have a median survival of ~1.5 years with azacitidine, and hematopoietic stem cell transplantation is their only curative option. Therefore, improved therapies are needed. This phase 1b study investigated safety and efficacy of venetoclax, a selective BCL-2 inhibitor, at the recommended phase 2 dose (RP2D: 400 mg for 14 days/28-day cycle), in combination with azacitidine (75 mg/m2 for 7 days/28-day cycle) for treatment-naive HR MDS (NCT02942290). Safety was the primary outcome, and complete remission (CR) rate was the primary efficacy outcome. Secondary outcomes included rates of modified overall response (mOR), hematologic improvement (HI), overall survival (OS), and time to next treatment (TTNT). As of May 2023, 107 patients received venetoclax and azacitidine combination at the RP2D. Best response of CR or marrow CR was observed in 29.9% and 50.5% of patients (mOR, 80.4%). Median OS was 26.0 months, with 1-year and 2-year survival estimates of 71.2% and 51.3%, respectively. Of 59 patients who were red blood cell and/or platelet transfusion-dependent at baseline, 24 (40.7%) became transfusion-independent on study, including 11 (18.6%) who also achieved CR. Fifty-one (49.0%) of 104 evaluable patients achieved HI. Median TTNT excluding transplantation was 13.4 months. Adverse events reflected known safety profiles for venetoclax and azacitidine, including constipation (53.3%), nausea (49.5%), neutropenia (48.6%), thrombocytopenia (44.9%), febrile neutropenia (42.1%), and diarrhea (41.1%). Overall, venetoclax plus azacitidine at the RP2D was well tolerated and had favorable outcomes. A phase 3 study (NCT04401748) is ongoing to confirm survival benefit of this combination.
Efficacy and Safety of Daratumumab in Intermediate/High-risk Smoldering Multiple Myeloma: Final Analysis of CENTAURUS
Authors: Landgren Carl Ola , Chari Ajai , Cohen Yael C. , Spencer Andrew , Voorhees Peter M , Sandhu Irwindeep , Jenner Matthew W , Smith Dean , Cavo Michele , van de Donk Niels W.C.J. , Beksac Meral , Moreau Phillippe , Goldschmidt Hartmut , Vieyra Diego , Sha Linlin , Li Liang , Rousseau Els , Dennis Robyn M. , Carson Robin , Hofmeister Craig C.
Published: December 2024

Early intervention of smoldering multiple myeloma (SMM) may delay progression to multiple myeloma. Here, we present the final analysis of the phase 2 CENTAURUS study (NCT02316106). In total, 123 patients with intermediate/high-risk SMM were randomized to intravenous daratumumab 16 mg/kg following a Long intense (n = 41), Intermediate (n = 41), or Short intense (n = 41) dosing schedule. At a combined median follow-up of 85.2 months, in the Long intense, Intermediate, and Short intense arms complete response or better rates were 4.9%, 9.8%, and 0%; overall response rates were 58.5%, 53.7%, and 37.5%; progressive disease/death rates were 0.096, 0.102, and 0.109 (P <0.0001 for all arms); and median progression-free survival was not reached, 84.4, and 74.1 months, respectively. Median overall survival was not reached in any arm. Thirty-six patients in the Long intense or Intermediate arms continued daratumumab in an optional extension phase after completing 20 cycles of per protocol treatment. Median (range) duration of study treatment was 44.0 (1.0-91.6), 35.2 (1.9-90.6), and 1.6 (0.1-1.9) months in the Long intense, Intermediate, and Short intense arms, respectively. No new safety signals were observed. With extended follow-up (median, ~7 years), these data highlight the tolerability of daratumumab and support ongoing trials investigating daratumumab as an early intervention for SMM. ClinicalTrials.gov Identifier: NCT02316106.
Air pollution is associated with increased risk of venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis
Authors: Lutsey Pamela L , Misialek Jeffrey R , Young Michael T , Berman Jesse David , Leiser Claire , Pope Zachary C , Cushman Mary , Folsom Aaron R. , Kaufman Joel D
Published: December 2024

Air pollution exposure may induce procoagulant effects, and chronic exposure may be linked to greater risk of venous thromboembolism (VTE). We tested the hypothesis that air pollution is associated with increased VTE risk in the prospective Multi-Ethnic Study of Atherosclerosis (MESA), which has well-characterized air pollution measures and information on potential confounding factors. We included 6,651 participants recruited in 2000-2002 (baseline age range: 45-84 yrs; 53% female). Air pollution was assessed with a validated spatio-temporal model that incorporates cohort-specific monitoring. Four indices of air pollution updated each fortnight over follow-up were averaged to estimate participant-level chronic exposure: fine particulate matter ≤2.5 micrometers in aerodynamic diameter (PM2.5), oxides of nitrogen (NOx), nitrogen dioxide (NO2), and ozone (O3). Mean±SD PM2.5 was 13.5±3.0 µg/m3, NO2 17.9±8.2 ppb, NOx 36.1±19.6 ppb, and O3 22.2±3.7 ppb. Incident VTE was identified using hospitalization discharge codes through 2018. A total of 248 VTE events accrued over a median follow-up of 16.7 years. After adjustment for baseline demographics, health behaviors and body mass index, the hazard ratio (95% CI) for incident VTE associated per 3.6 µg/m3 higher PM2.5 was 1.39 (1.04-1.86); per 13.3 ppb higher NO2 concentration was 2.74 (1.57-4.77); and per 30 ppb higher NOx was 2.21 (1.42-3.44). O3 was not related. In this prospective community-based cohort with individual-level estimation of chronic air pollution exposure, higher average ambient concentrations of PM2.5, NO2 and NOX were associated with greater risk of developing VTE. Findings add to accumulating evidence of adverse health effects attributed to air pollution exposure.
β-Thalassemia minor is associated with high rates of worsening anemia in pregnancy
Authors: Langer Arielle L. , Goggins Brynn B. , Esrick Erica B. , Fell Geoffrey , Berliner Nancy , Economy Katherine E.
Published: December 2024

We identified 347 pregnancies in patients with β-thalassemia minor. Hemoglobin was <9 g/dL in 31% during third trimester and 7.6% at delivery. Postpartum hemorrhage occurred in 8.9%. Forty-six percent of IV iron administration was to iron-replete patients.
Comparison of different treatment options in submacular haemorrhage
Authors: Hillenmayer Anna , Wertheimer Christian M. , Hillenmayer Marlene , Strehle Laura D. , Hartmann Lennart M. , Vounotrypidis Efstathios , Wolf Armin
Published: December 2024

Background/aims

Submacular haemorrhages (SMH) cause significant visual impairment. Until now, the comparative effectiveness of different treatment approaches remains inconclusive without clear treatment guidelines. The aim of our study was to evaluate the effectiveness of 5 surgical treatment modalities in terms of visual prognosis and success rate.

Methods

This retrospective study included 201 patients with SMH. Primary endpoint was best corrected visual acuity (BCVA), secondary endpoints included haemorrhage size and complications. Group 1 was treated with pneumatic displacement and rtPA-injection. Group 2 followed the "Manchester protocol" with rtPA-injection and—if needed—a standardised secondary procedure with pars plana vitrectomy (ppV) and subretinal rtPA. Group 3 underwent vitrectomy with subretinal rtPA, group 4 vitrectomy only and group 5 received subretinal lavage.

Results

Baseline characteristics were a mean age of 79 years and a follow-up of 4.6 months. Pre-intervention BCVA of 1.7 logMAR improved to 1.4 logMAR at follow-up. A gain of > 0.2 logMAR was achieved in 47% of patients, while 20% lost > 0.2 logMAR. Only group 2 achieved a statistically significant visual gain. While group 5 was statistically larger in haemorrhage size preoperatively (p < 0.05), all groups were statistically equal in SMH size at follow-up. Complications led to additional interventions in 20% of patients.

Conclusions

No significant change in visual prognosis could be achieved depending on the intervention. As more invasive techniques seem to lack the benefit of a better postoperative prognosis while carrying higher risks, it may be beneficial considering a less invasive option first.
Effects of Eccentric Exercise of the Extensors on Eccentric Exercise-Induced Muscle Damage of the Flexors in Limbs
Authors: Chen Trevor C. , Tseng Wei-Chin , Kang Hsing-Yu , Chan Chuan-Wei , Chen Hsin-Lian , Nosaka Kazunori
Published: December 2024

Introduction

We tested the hypothesis that muscle damage protection effect would be induced by its antagonist muscle eccentric exercise.

Methods

Sedentary young (20-28y) men were randomly assigned into six groups; three groups each for arm or leg exercise group (n = 12/group). One group performed two bouts of 30 maximal eccentric contractions (30MaxEC) of the elbow flexors (EF) or 60 maximal eccentric contractions (60MaxEC) of the knee flexors (KF) using a different arm (contra-EF-EF) or leg (contra-KF-KF) between bouts. The other two groups performed 30MaxEC of the elbow extensors (EE) or 60MaxEC of the knee extensors (KE) first followed by the 30MaxEC of EF or 60MaxEC of KF using the ipsilateral (ipsi-EE-EF, ipsi-KE-KF) or contralateral limb (contra-EE-EF, contra-KE-KF). The two exercise bouts were separated by 2 weeks for all groups. Changes in muscle damage markers before to 5 days following exercise were compared among the groups by mixed-design two-way ANOVAs.

Results

Changes in the markers following the second bout of the ipsi-EE-EF, contra-EE-EF, ipsi-KE-KF, and contra-KE-KF groups were smaller (P < 0.05) than those after the first bout of the contra-EF-EF and contra-KF-KF groups, respectively. The changes after the second bout were smaller (P < 0.05) for the ipsi-EE-EF than contra-EE-EF, and ipsi-KE-KF than contra-KE-KF group; however, those in the contra-EE-EF and contra-KE-KF groups were larger (P < 0.05) than those following the second bout of the contra-EF-EF and contra-KF-KF groups.

Conclusions

These results showed that the magnitude of muscle damage of EF or KF was reduced by the initial bout of EE or KE eccentric exercise performed by both ipsilateral and contralateral limbs, suggesting that muscle damage protective effect is conferred by the antagonist muscle in the same and opposite limbs.
Strategic management of the development of social systems
Authors: Brykin Arseniy , Peremibeda Pavel , Tyurikov Aleksandr
Published: December 2024

The textbook introduces the essence, content and features of strategic management of the development of social systems, including the diagnosis of management systems, as well as subsequent planning, forecasting and design of management systems, monitoring and control over the implementation of strategic decisions and documents; contains methodological, theoretical and practical materials.
The workshop on each topic builds analytical and socio-managerial skills at the strategic level, including the areas of public administration (including strategic planning in the Russian Federation) and corporate governance.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It was tested during classes on the discipline "Management of the strategic development system and its effectiveness" at the Financial University under the Government of the Russian Federation.
For undergraduates in the field of Sociology (the program "Social management of strategic development", as well as disciplines (courses, programs) with similar or similar content).
Economic analysis (with traditional and interactive forms of education)
Authors: Klimova Natal'ya
Published: December 2024

The textbook reveals the role, subject, methods and techniques of economic analysis, methodology for analyzing the use of resources and the achieved results of financial and economic activities of organizations, including the search for economic reserves; control questions, tasks for independent work of students, business games, tests and tasks in the discipline "Economic analysis" are given.
For teachers, graduate students and students of economic specialties, as well as for practitioners — accountants, financiers, managers, entrepreneurs and heads of organizations.
Multi-criteria optimization in supply chains
Authors: Brodeckiy Gennadiy , Gusev Denis , Gerami Viktoriya , Sviridova Ol'ga , Shidlovskiy Ivan
Published: December 2024

The textbook contains current types of problems of choosing the best solutions for many criteria used in modeling supply chains. To solve the problems, methods and models are presented, including traditional and special approaches to multi-criteria optimization of solutions. Special attention is paid to additional opportunities for improving such approaches to improve decision optimization procedures in supply chain modeling, and the possibilities of alternative filtering procedures are considered. Special procedures are presented to eliminate the phenomena of inadequate choice and effectively adapt the best choice to the preferences of the decision-maker. Each section offers an extensive list of questions, tests and assignments on the subject presented.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students and postgraduates of economic specialties. It will also be useful for a wide range of managers and entrepreneurs who want to organize their business more effectively.
Modern technologies of colonic esophagoplasty in children
Authors: Chepurnoy Mihail
Published: December 2024

The monograph is devoted to the study of the features of esophagoplasty in children with post-burn scarring of the esophagus with clarification of the sources of arterial vascularization of various segments of the esophagus with the determination of their distribution basins in relation to double esophagostomy and esophagoplasty.
It is intended for the training of highly qualified personnel in the areas of training 31.06.01 "Clinical medicine in scientific specialties" 3.1.9 "Surgery" and 3.1.11 "Pediatric surgery".
Correction of the violation of the syllabic structure of the word in older preschool children with dysarthria
Authors: Biba Anna , Ivanovich Ekaterina
Published: December 2024

The monograph describes the stages, content and means of correcting and developing the syllabic structure of words in older preschool children with dysarthria. The appeal to this problem is explained by the tendency to increase the number of children with pathology of the pronunciation side of speech, which negatively affects their mastery of the grammatical structure of speech, writing and reading. The symptoms and mechanisms of dysarthric disorders and methods of correcting syllabic structure are widely represented in speech therapy. Nevertheless, the specifics of the sequential correction of violations of all types of syllabic structure need to be clarified.
It is intended for practicing speech therapists. It can be used in the professional training of future teachers of special (defectological) education.
Media Psychology
Authors: Harlanova Yuliya
Published: December 2024

Modern mass media represent an important aspect of society, and a variety of media products help a person to realize himself professionally. From the textbook, it will be possible to learn how information resources are created from a psychological point of view, how they can be used in various fields of professional activity.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is intended for use in the educational process of higher educational institutions in the course of studying disciplines of a sociological and cultural profile. It will also be interesting for specialists of a wide profile, since media today manifest themselves in different spheres of society, help promote various products, and influence the realization of many professional goals.
Smoothness and geometry of movement in neurorehabilitation (formalization of quality of life assessment)
Authors: Vasil'ev Oleg , Achkasov Evgeniy , Rohlin Andrey
Published: December 2024

The monograph is aimed at improving the quality of medical rehabilitation using digital information technologies.
The monograph presents an interdisciplinary system-structural analysis of one of the promising areas in the field of neurorehabilitation — the assessment of smoothness and geometry of motion, which may be little known to the domestic reader. All the above mathematical models and formulas have been analyzed and brought to a single designation. In conclusion, the authors present their generalizing point of view and provide their own materials in the field of another promising area — the assessment of "measures of effort".
It is aimed at a wide range of specialists involved in rehabilitation, representatives of different fields of knowledge: clinicians, diagnosticians, cyberneticists, medical physicists, programmers, engineers, etc.
Does Blockholders’ Concentration Influence Spending on Corporate Social Responsibility? – Evidence from the Indian Firms
Authors: Potharla Srikanth
Published: December 2024

This study investigates the relationship between blockholder concentrationand corporate social responsibility (CSR) spending in Indian firms, using stakeholderidentification and salience theory. This study aims to fill a gap in the literature byexamining how the concentration of blockholders, particularly external Blockholdersand promoters, influences CSR activities. The analysis covers 1,918 firms from 2014to 2023, using data from the Centre for Monitoring Indian Economy (CMIE) database. Empirical methods, including four regression models, are employed to examine the significanceof blockholder attributes on CSR spending. The results demonstrate the significantpositive impact of blockholder concentration on CSR activities. Specifically, theinfluence of external blockholders on CSR spending is greater than that of promoters. Furthermore, the study finds that single promoters with large investments are more inclinedtowards CSR spending, while interest in CSR diminishes when multiple promotershold significant shares. This study uniquely contributes to the literature by providingan insightful analysis of blockholder concentration’s impact on CSR, highlighting the differential effects between external blockholders and promoters, and underscoringthe importance of strategic blockholder alliances in enhancing CSR efforts. Thesefindings offer valuable insights for corporate managers and policymakers in emergingeconomies such as India.
Nursing as a Public Trust Profession
Authors: Czerwińska Pawluk Iwona , Dębska Anna , Zukow Walery
Published: December 2024

Introduction. Nursing is widely recognized as a public trust profession due to its emphasis on professionalism, ethical standards, and patient-centered care. The profession demands adherence to legal regulations and ethical norms, fostering trust through its critical role in healthcare delivery. This study aims to explore patients' perceptions of nursing as a public trust profession, focusing on key factors such as professionalism, ethical compliance, and personal attributes of nurses.
Objective. The primary goal of this study was to assess patients' opinions regarding nursing as a public trust profession and identify the specific attributes and competencies that underpin this perception.
Methods. The study employed a diagnostic survey method using a structured questionnaire. A total of 100 patients from a healthcare facility in the Mazovian Voivodeship participated. Statistical analyses, including descriptive statistics, chi-square tests, t-tests, ANOVA, correlation analyses, and factor analysis, were conducted using IBM SPSS 29.
Results. The findings revealed that 95% of respondents identified professionalism and high engagement in care as crucial factors for trust. Empathy and compassion were also rated highly (95%), along with confidentiality (90%). The chi-square test showed significant differences in the perception of professionalism (Chi2 = 140.80, P < 0.001), and ANOVA demonstrated the impact of nurses' attitudes on trust (F = 116.93, P < 0.001). Factor analysis indicated that professionalism and engagement were the primary components influencing trust perceptions, explaining 100% of variance.
Conclusions. Professionalism, ethical conduct, and interpersonal skills are pivotal in establishing nursing as a public trust profession. These attributes are essential for patient trust and align with global standards in nursing practice. The study underscores the need to maintain high ethical and professional standards to sustain public trust in the profession.
Comparative Efficacy of Amiodarone and Lidocaine in Treating Cardiac Arrest Due to Ventricular Fibrillation and Pulseless Ventricular Tachycardia in Adults. A Literature Review
Authors: Dryja Patryk , Boczar Agata , Orzołek Izabela , Stawicka Izabela , Jarmołowicz Jakub , Solisch Sven , Solisch Bianka
Published: December 2024

Introduction:Sudden cardiac arrest (SCA) is a critical emergency, with shockable rhythms like ventricular fibrillation (VF) and pulseless ventricular tachycardia (VT) posing challenges. Amiodarone and lidocaine are key antiarrhythmic drugs used with defibrillation. While both improve hospital admission rates, their effects on survival and neurological outcomes remain unclear. This review examines their comparative efficacy to guide clinical practice.Materials and methods:A thorough literature review was performed using electronic databases. The search was restricted to English-language articles published from 1970 to 2024.Aim of the study:The aim of this study is to systematically review and compare the efficacy of lidocaine and amiodarone in the treatment of cardiac arrest due to ventricular fibrillation and ventricular tachycardia in adults. This review seeks to evaluate the existing literature to determine the effectiveness and clinical outcomes associated with each medication.Conclusions: The comparative analysis of amiodarone and lidocaine highlights their respective strengths and limitations in managing cardiac arrest, offering valuable insights for clinical practice. Amiodarone stands out as the preferred antiarrhythmic agent due to its significant efficacy in improving short-term outcomes, such as return of spontaneous circulation (ROSC) and survival to hospital admission. Overall, amiodarone's efficacy and broader applicability position it as the first-line agent for shock-refractory ventricular fibrillation (VF) and pulseless ventricular tachycardia (pVT). Lidocaine serves as an important alternative in specific scenarios. Future research should aim to optimize antiarrhythmic protocols, improve long-term survival and neurological outcomes, and explore innovative approaches to resuscitation.
Minimal hepatic encephalopathy - from cirrhosis to neurological disorders
Authors: Jarmołowicz Jakub , Boczar Agata , Dryja Patryk , Solisch Sven , Stawicka Izabela , Orzołek Izabela
Published: December 2024

Introduction and aim
Minimal hepatic encephalopathy (MHE) is a subtle but significant brain dysfunction resulting from chronic liver damage, with symptoms that can be difficult to detect. It affects patients' quality of life by causing problems with concentration, memory, and motor coordination. Untreated MHE may progress to more severe neurological disorders, such as overt hepatic encephalopathy. The importance of this condition lies in its impact on patients' daily functioning and the increased risk of accidents, particularly in situations requiring quick responses, such as driving.Neurological symptoms caused by the disease are potentially reversible with treatment.
 
Materials and Methods 
Available literature from the PubMed and Google Scholar databases was reviewed using the following keywords: "minimal hepatic encephalopathy," "hepatic encephalopathy," "cirrhosis,"  and "SIBO."
 
 Conclusion 
The significance of Minimal Hepatic Encephalopathy is crucial from the perspective of preventing further progression and the onset of overt hepatic encephalopathy, as well as improving the quality of life for our patients. Patients and their families are often unaware of the condition, and the cognitive impairments are frequently underestimated. Enhancing diagnostic methods would enable physicians to identify these patients more promptly.
Chłopi a mityczny początek narodu w kronikach Marcina Bielskiego i Marcina Kromera
Authors: Kruk-Siwiec Justyna
Published: December 2024

Artykuł analizuje mity fundacyjne zawarte w kronikach Marcina Bielskiego i Marcina Kromera pod kątem obrazowania w nich chłopów. Punktem wyjścia jest tu polemika z popularnym przekonaniem, że w historiografii polskiej XVI stulecia występował mit podboju uzasadniający panowanie szlachty nad plebejuszami. Dzięki zbadaniu inicjalnych partii kronik udowodniono, że w tych dwóch kluczowych pomnikach staropolskiej historiografii nie pojawił się mit podboju chłopów. Zarówno Bielski, jak i Kromer wykorzystują inne strategie legitymizowania podziałów stanowych, co zostało w artykule wskazane i omówione.
Niepłodność i próby jej leczenia – kwestie zdrowotne, moralne i religijne (XVI i XVII w.)
Authors: Odrzywolska Anna
Published: December 2024

Przedmiotem artykułu jest zjawisko niepłodności rozpatrywane w aspekcie społeczno-kulturowym. Omówione zostaną przyczyny niepłodności według diagnostyki obowiązującej w XVI i XVII w., zgodne z teorią humoralną, według której dobierano też metody terapeutyczne. Zasadniczą treść tworzą sposoby leczenia, jakie proponowali ówcześni autorzy przekazów źródłowych. Podstawę źródłową stanowią źródła narracyjne, głównie zielniki renesansowe i poradniki gospodarskie.
Zbigniewa Morsztyna Treny żałosne Apollina z Muzami przy oddaniu ostatniej usługi ciału Jana Hoverbecka z 1682 roku. Odnaleziony druk i nieznane ustępy twórczości poety
Authors: Grześkowiak Radosław
Published: December 2024

Autor odnalazł nieznany polskim badaczom druk dzieła Zbigniewa Morsztyna Treny żałosne Apollina z Muzami przy oddaniu ostatniej usługi ciału Jana Hoverbecka z 1682 r., którego tekst znany był dotąd z niepełnej rękopiśmiennej kopii z XVII w. (brak w niej 74 wersów cyklu). Artykuł zawiera komentowaną edycję nieznanych pieśni funeralnego zbioru, a także omawia okoliczności powstania, analizuje jego poetykę oraz miejsce w literackiej oprawie pogrzebu (uroczystość uczczono też sześcioma drukami niemieckojęzycznymi i dwoma łacińskimi).
Z ineditów Wacława Potockiego: Siedm pieśni na siedm artykułów Modlitwy Pańskiej (komentowana edycja krytyczna)
Authors: Piotrowiak Dariusz
Published: December 2024

Artykuł zawiera edycję krytyczną cyklu Siedm pieśni na siedm artykułów Modlitwy Pańskiej autorstwa Wacława Potockiego. Utwory te, powstałe najprawdopodobniej w latach siedemdziesiątych XVII w., a z pewnością po 1677 r., zachowały się w jednym przekazie: jest nim rękopiśmienny kodeks przechowywany w zbiorach Biblioteki Narodowej (sygn. 3047/III). Drukiem ukazują się one po raz pierwszy. W aneksie zdecydowano się przedrukować również dotychczas niewydaną Pieśń XII z Pieśni nabożnych, w której Potocki raz jeszcze nawiązał do tematyki opracowanej w ramach prezentowanego cyklu.
Patient satisfaction with nursing care during biological therapy for inflammatory bowel disease: an observational study
Authors: Napolitano Daniele , Cocchieri Antonello , Orgiana Nicoletta , Durini Eleonora , Strazzeri Martina , Fanali Caterina , Poscia Andrea , Scaldaferri Franco
Published: December 2024

Background:

Patient satisfaction is related to patients’ expectation of health services, which they use to satisfy their needs for maintaining health and curing disease. The management of inflammatory bowel disease (IBD) involves complex diagnostic and therapeutic approaches, in which nurses play a decisive role. The present study evaluated patients’ overall perception of the quality of nursing care received during biological therapy.

Methods:

The researchers recruited patients who underwent outpatient biological therapy for IBD at a health institution between October and December 2021. They evaluated patient satisfaction of nursing care using three sections of the Newcastle Satisfaction Nursing Scale (NSNS). Participants were categorised according to time of follow-up: long (>12 months), short (≤12 months).

Results:

The researchers administered 234 questionnaires and enrolled 200 participants (response rate: 86.2%). The overall levels of satisfaction relating to scales A and B of the NSNS were 88.4 and 90.7, respectively. Patient loyalty was found to have a significant positive affect on satisfaction for scales A (90.5 versus 82.9, long versus short follow-up) and B (92.5 versus 86.0, long versus short follow-up) (p<0.05).

Conclusions:

The level of patient satisfaction at the centre was excellent, indicating that the overall perception of nursing care was very high.
The state of IBD care in the UK: why it is time for more investment
Authors: Cooper Geraldine
Published: December 2024

A look at the new IBD UK national report on inflammatory bowel disease in the UK, which highlights the shortfalls in current practice that must be addressed.
The Influence of Body Fat Percentage on Body Type Cognitive Bias Among Young Chinese Hospital Staff Members: A Cross-Sectional Study
Authors: Wang Lu , Wen Jing , Xu Zhen , Guan Ke , Chen Yongchun
Published: December 2024

Aims/Background This study expanded the existing literature on obesity and distortion of body image by examining subjective and objective body type among young medical workers, specifically investigating whether fat percentage independently influences body type cognitive bias.

Methods We recruited 264 participants (41.29% male, mean age 26.2 ± 3.1 years, mean body mass index (BMI) 21.7 ± 3.1 kg/m2) at a comprehensive hospital in central China. The questionnaire responses of the enrolled participants concerning basic information and body type self-assessment were extracted. Their weights and body compositions were evaluated by the bioelectrical impedance analysis technique (BIA). Objective indicators included measured weight, BMI, fat percentage, waist circumference (WC) and waist-to-hip ratio (WHR).

Results Based on this sample, the prevalence rate of body type cognitive bias was 28.79%. For women, the univariate regression analysis showed that fat percentage was significantly correlated with body type cognitive bias (odds ratio [OR] 1.107, 95% confidence interval [CI] 1.033–1.185, p = 0.004). BMI (OR 1.303, 95% CI 1.098–1.546, p = 0.002) and WC (OR 1.109, 95% CI 1.043–1.180, p = 0.001) might also be positively associated with body type cognitive bias. After adjusting for age, BMI, WHR, and job position, the risk of body type cognitive bias decreased with fat percentage up to the first inflection point (26.8%) (OR 0.78, 95% CI 0.62–0.98, p = 0.036), and then it increased up to the second inflection point (33.0%). When fat percentage exceeded 33.0%, the relationship lost statistical significance. No significant relationships were found for men.

Conclusion Fat percentage is an independent, nonlinear factor influencing women's body type cognitive bias. Gender and fat percentage should be considered when establishing weight management intervention strategies to prevent obesity from becoming a public health problem.
The Impact of Child and Adolescent Inpatient Psychiatric Admissions Out-of-Area or to Adult Wards: A Systematic Review
Authors: Holland Josephine , Lewis Leonie , Wreford Alice , Singh-Lalli Hardeep , Roe James , Sayal Kapil
Published: December 2024

Aims/Background Child and adolescent psychiatric inpatient admissions out-of-area or to adult wards are frequently discussed in the national media. No previous systematic reviews have investigated the impact of such admissions.

Methods Systematic searches of MEDLINE, Embase, CINAHL, PsycINFO, PsycArticles, King’s Fund, Google Scholar, The Health Foundation, Social Care Online, Cochrane Library, Royal College of Psychiatrists, Web of Science and Econ light databases were conducted alongside grey literature searches. All eligible studies investigating the impact of acute psychiatric inpatient admission out-of-area or to adult wards in children and adolescents were included. Risk of bias was assessed using an adapted version of the Hawker critical appraisal tool.

Results 18 studies were included (4 reported on out-of-area admissions, 13 on adult ward admissions, 1 study reported on both). Study quality was variable. Out-of-area admission impacts included longer emergency department waits, higher travel costs for families, and were described as ‘time-inefficient’. For studies of admissions of under-18s to adult psychiatric wards the most commonly reported impact was on length of stay. Opinions from staff and young people of these types of admissions were mostly negative.

Conclusion Further studies looking at the full range of impacts of these admissions over the long term are needed.
The big picture
Authors: Manners Lala
Published: December 2024

In the final instalment of her series, Dr Lala Manners addresses the tricky area of holistic assessment of physical development
Filling the gaps
Authors: Crown Hannah
Published: December 2024

How can the sector meet training needs amid the unprecedented growth expected due to the new funded entitlement, asks Hannah Crown
Loss of Substitutability: A Note of Disparity between WTP and WTA
Authors: Dragicevic Arnaud Z.
Published: December 2024

This note examines the disparity between willingness-to-pay (WTP) and willingness-to-accept (WTA) in the nonmarket valuation of environmental public goods. We observe that the commonly cited substitution effect and endowment effect, while often used to explain this disparity, address distinct conceptual questions. Building on this, we propose an integrated model that incorporates both effects within a reference-dependent framework. Our findings demonstrate that compensation demanded for lost substitutability is unbounded under a neoclassical framework but constrained within a loss-aversion context. These results offer a foundation for empirical testing to advance understanding of this persistent issue.
Influence of Deep Bedding and Fermented Feed Supplementation on the Behavioral Patterns, Adult Fly (Musca domestica) Density and Performance of Crossbred Pigs
Authors:   Division of Animal Sciences, Faculty of Agricultural Technology, Chiang Mai Rajabhat University, Chiang Mai 50300, Thailand, Krutthai Nuttawut , Chaiwang Niraporn ,   Division of Animal Sciences, Faculty of Agricultural Technology, Chiang Mai Rajabhat University, Chiang Mai 50300, Thailand, Sringarm Korawan ,   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand, Arjin Chaiwat ,   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand, Mekchay Supamit ,   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand, Marupanthorn Kulisara ,   Division of Animal Sciences, Faculty of Agricultural Technology, Chiang Mai Rajabhat University, Chiang Mai 50300, Thailand, Wattanakul Watcharapong ,   Division of Animal Sciences, Faculty of Agricultural Technology, Chiang Mai Rajabhat University, Chiang Mai 50300, Thailand
Published: December 2024

This study determined the effects of deep bedding floor and fermented feed supplement on the behavioral pattern and adult fly (Musca domestica) density that would be affect to the performance of crossbred pigs. The performance data from 64 (Thai native x Meishan x Duroc) crossbreds were combined from two replicated studies. Pig behavior was continuously video recorded in a real-time mode on Day 1 (initial day), 2, 3, 7 and the end day of Month 1, 2, 3 and 4 for 32 pigs in one block. A 2 x 2 factorial arrangement in a completely randomized design was used with four replicates in one block. Factor A was a deep bedding floor (DB) or solid bedding of concrete floor (SB). Factor B was a feed type of concentrate feed supplemented with a fresh banana stem (BF+CON) or fermented banana stem (FF+CON). The results showed that effects of floor type and feed type on production performance were significant (P<0.05), with concrete floors showing better performance than deep bedding. The study found no significant impact of feed type on growth performance in pigs. Nevertheless, floor type and feed type interaction on production performance was significant for final weight, ADG, and FCR throughout the experiment (0–120 days). However, the behavior of pigs was influenced by floor type. DB pigs spent more time exploring the pen, but spent less time standing and walking than SB pigs. DB variations were found to be dispersed, with positive correlations between standing, nuzzling, walking, and feeding. Despite the possibility of flies being flown across the row, DB row pigs had significantly (P<0.05) fewer flies than SB row pigs. The heatmaps showed that the two groups have different behavioral dependency. The study concluded that the deep bedding floor type allowed for natural exploring behavior of the pigs and reduced the number of flies in the system. However, adverse effects were observed in performance, indicating the need for further study to improve the system.
Interpolation and fundamental principle
Authors: Krivosheev Aleksandr Sergeevich , Krivosheeva Olesya Aleksandrovna
Published: December 2024

In this work we study the spaces of functions analytic in convex domains in the complex plane. We consider subspaces of such spaces, which are invariant with respect to the differentiation operator. We study the fundamental principle problem for an invariant subspace, that is, the problem on representing all its elements by a series of eigenfunctions and generalized eigenfunctions of the differentiation operator in this subspace, which are the exponentials and exponential monomials. We provide a complete description of the space of sequences of the coefficients of the series, by which we represent the functions from the invariant subspace. We also study the multiple interpolation problem in the spaces of entire functions of exponential type. We consider the duality of interpolation problem and fundamental principle. This duality problem is completely solved. We established the duality of the fundamental principle problem and interpolation problem for an arbitrary convex domain with no restrictions.
Specification of asymptotic Pólya type estimate for Dirichlet series converging in half - plane
Authors: Belous Tat'yana Ivanovna , Gaisin Ahtyar Magazovich , Gaisin Rashit Akhtyarovich
Published: December 2024

We study the asymptotic behavior of a Dirichlet series with positive exponents, converging in the left half - plane, on an arc of bounded slope ending on the convergence line. In the paper we obtain conditions under which the sum of the Dirichlet series satisfies an asymptotic equality of Pólya type on a set, the upper density of which is equal to one. In 2023 we obtained results related to dual cases. We showed that a Pólya type identity holds on an asymptotic set of positive upper density depending on the slope coefficient (Lipschitz constant) of the arc. In this paper, we prove a common theorem covering both of these cases, and we show that the asymptotic set has an upper density, which is equal to one.
Series of boundary value problems for Euler - Darboux equation with two degeneracy lines
Authors: Podkletnova Svetlana Vladimirovna
Published: December 2024

In this paper we introduce a new partial differential equation, which is an extension of the known Euler - Darboux equation. On the base of the proven properties of solution to introduced equation we explicitly find general solutions for various values of parameters, prove existence and uniqueness theorems. Basing on the general solutions of introduced equation, we solve the Cauchy problems and modified Cauchy problems in an upper right triangle. We find explicit solutions and prove the existence and uniqueness theorems for the posed problems.
From a color-blind perspective: exploring frustration and confidence in schoolchildren with simulated color vision deficiency
Authors: Dlay Harpreet K. , Jordan Gabriele
Published: December 2024

Congenital red–green color vision deficiencies (CVDs) affect 8% of males and 0.5% of females. Given the growing number of school materials using color as a resource to learn, affected children are said to be at a clear disadvantage. However, due to an absence of mandatory screening, CVD goes unnoticed in the majority of children with the condition, and necessary adjustments are not made, raising questions about the potential impact on their future motivation to learn. The aim of the current study was to examine children’s levels of frustration and self-confidence after inducing CVD. Commercially available Variantor spectacles (simulating dichromacy, affecting 2% of males) were worn by the children while they performed a typical color-based task at school. Using a counterbalanced, repeated measures design, the study was conducted on 181 color-normal schoolchildren performing age-appropriate math tasks. Wilcoxon signed-rank tests revealed significantly poorer task performance, higher levels of frustration, and lower confidence ratings in the simulation condition. We argue that frequent failure at color-related tasks can lead to academic and social–emotional problems, highlighting the need to reintroduce CVD screening at an early age to ensure that appropriate support can be given to CVD children at school.
Circular dichroism in achiral metasurfaces induced by spatially selective coupling with molecules
Authors: Han Baojuan , Yang Xiaodong , Gao Jie
Published: December 2024

Achiral metasurfaces with near-field optical chirality have attracted great attention in molecular sensing and chiral emission control. Here, the circular dichroism (CD) response of an achiral metasurface induced by spatially selective coupling with polymethyl methacrylate (PMMA) molecules is demonstrated. A designed achiral metasurface with a V-shaped resonator exhibits large optical chirality with a strongly dissymmetric distribution under circular polarization. By introducing a PMMA molecule layer on top of the metasurface, which covers the area with large optical chirality, CD in absorption of 0.38 and a dissymmetric factor of optical chirality
g

c

of 0.16 are obtained. Furthermore, an analysis of the coupled harmonic oscillator model reveals stronger coupling strength between the PMMA layer and the metasurface under RCP incidence, compared to the LCP case. Moreover, it is shown that the far-field CD response of the metasurface is linearly correlated with the dissymmetric near-field optical chirality distribution. The demonstrated results present the potential for advancing applications in chiral molecule vibrational sensing, thermal emission control, and infrared chiral imaging.
All-fiber E + S band continuously tunable bismuth-doped germanosilicate fiber laser
Authors: Zhai Ziwei , Sahu Jayanta K.
Published: December 2024

In this Letter, we present an all-fiber bismuth (Bi)-doped germanosilicate fiber laser that is continuously tunable within the range of 1425–1475 nm, enabled by a tunable optical filter. A maximum output power of 86.4 mW was achieved at 1450 nm with a slope efficiency of 13.7%. It is, to the best of our knowledge, the first demonstration of an all-fiber tunable continuous-wave (CW) bismuth-doped fiber laser (BDFL) operating in the E + S band. Moreover, a bismuth-doped fiber amplifier (BDFA) was constructed to further scale the laser output power to 159.2 mW with a 21% slope efficiency. Across the 1425–1475 nm range, we achieved >117 mW output power with >50 dB in-band optical signal-to-noise ratio (OSNR).
High-speed multifunctional photonic memory on a foundry-processed photonic platform
Authors: Rahimi Kari Sadra , Tamura Marcus , Guo Zhimu , Huang Yi-Siou , Sun Hongyi , Lian Chuanyu , Nobile Nicholas , Erickson John , Moridsadat Maryam , Ríos Ocampo Carlos A. , Shastri Bhavin J. , Youngblood Nathan
Published: December 2024

The integration of computing with memory is essential for distributed, massively parallel, and adaptive architectures such as neural networks in artificial intelligence (AI). Accelerating AI can be achieved through photonic computing, but it requires nonvolatile photonic memory capable of rapid updates during on-chip training sessions or when new information becomes available during deployment. Phase-change materials (PCMs) are promising for providing compact, nonvolatile optical weighting; however, they face limitations in terms of bit precision, programming speed, and cycling endurance. Here, we propose a novel photonic memory cell that merges nonvolatile photonic weighting using PCMs with high-speed, volatile tuning enabled by an integrated PN junction. Our experiments demonstrate that the same PN modulator, fabricated via a foundry-compatible process, can achieve dual functionality. It supports coarse programmability for setting initial optical weights and facilitates high-speed fine-tuning to adjust these weights dynamically. The result shows a 400-fold increase in volatile tuning speed and a 10,000-fold enhancement in efficiency. This multifunctional photonic memory with volatile and nonvolatile capabilities could significantly advance the performance and versatility of photonic memory cells, providing robust solutions for dynamic computing environments.