bluuebunny/crossref_metadata_2025 huggingface dataset:
La COVID-19, pantallas y reflexividad social. Cómo el brote de un patógeno está afectando nuestra cotidianidad
Authors: Díez García Rubén , Belli Simone , Márquez Israel V.
Published: September 2020

Con este texto queremos hacer una primera aproximación a los patrones de conducta que comparten los individuos a lo largo de las diferentes etapas de desarrollo de la pandemia. Para ello, nos acercaremos a las prácticas comunicativas mediadas por pantallas y, en particular, a los usos de las herramientas de mensajería instantánea como medio de información, comunicación y emoción durante el distanciamiento social provocado por la pandemia. En concreto, nos centraremos en la popular plataforma de mensajería WhatsApp, una plataforma clave como tecnología cotidiana que media la interacción social en nuestros grupos sociales primarios y secundarios, pero también la propia comunicación social en torno a este fenómeno.
Tercer caso de vasculitis leucocitoclástica cutánea secundaria al uso de oxacilina: reporte de caso
Authors: Arsanios Daniel Martin , Cabezas Daniel Felipe , Barragán Andres Felipe , Estupiñán María Fernanda , Calderón Carlos Mauricio , Quintero-Muñoz Elías
Published: September 2020

La vasculitis leucocitoclastica es una patologìa que compromete los vasos pequeños y cuya causa predominantemente se ha descrito como idiopatica. Se presenta el caso de una mujer de 78 años hipertensa, diabética y con enfermedad renal crónica en estadio 5, que presentó lesiones limitadas a la piel posterior a la administración de oxacilina para manejo de bacteremia por SAMS. La presentación clínica se basó en purpuras palpables predominantemente en miembros inferiores y lesiones dolorosas coalescentes que formaban ampollas de contenido hemorrágico. Estas lesiones resolvieron gradualmente después del cambio de la terapia mencionada anteriormente. La biopsia fue compatible con vasculitis leucocitoclástica, con paraclínicos que descartaron causas infecciosas y autoinmunes.
NANOENKAPSULASI ASAM STEARAT DENGAN MODIFIKASI GRAFENA mG/SA WALL-CORE SEBAGAI KOMPOSIT PERUBAHAN FASA
Authors: Gea Saharman , Purwandari Vivi
Published: September 2020

The fabrication of phase-changed composite (PCC) utilized to store thermal energy through encapsulation has been performed by utilizing the stearate acid (SA) and modified graphene (mG) with sentrimoinum bromide (CTAB). The composite was fabricated via latex method, while the liquid SA was able to be encapsulated and stabilized due to the presence of mG. The active phase of SA altered to be a thermal storing site obtained from latent heat, while the mG wall has protective features which can prevent the leakage of SA core during the transition phase. The active phase itself increased the thermal conductivity from 4.93 W/mK to 7.65 W/mK with maximum storing energy for 84.8%. The stable form of mG was measured extremely low for 2 phr with an average particle size of 13.68 nm. Thus, mG wall has excellent thermal stability and effective protection in shielding the SA core which improves the thermal properties of the composite.
Tildelingsmodeller og effektbaserede principper i den offentlige sektor
Authors: Bukh Per Nikolaj , Christensen Karina Skovvang
Published: September 2020

I de senere år er fokus øget både på den effekt, der opnås af de offentlige indsatser, og på de ressourcer, der medgår. Det nødvendiggør ændringer i den økonomiske styring, og i den måde ressourcetildelingsmodellerne fungerer på. Artiklen sætter fokus på ledelsesrummet, der drejer sig om, hvilke beslutninger man kan træffe, hvilke konsekvenser af beslutninger man har ansvar for, samt hvordan beslutningerne og konsekvenserne af dem påvirker de økonomiske rammer. Artiklens centrale pointe er, at tildelingsmodellerne konstruerer ledelsesrummet. Effektbaseret økonomistyring er derfor et spørgsmål om tildelingsmodeller (og dermed ledelsesrum), der sikrer helhedsorientering og sammenhængende styring af forløb. For at kunne vurdere tildelingsmodellernes egenskaber ser vi på omkostningseffektivitet som det centrale styringskriterie. I artiklen skelnes mellem direkte effektbaserede tildelingsmodeller, hvor tildelingskriterierne er formuleret som effektmål, og indirekte effektbaserede tildelingsmodeller, hvor tildelingskriterierne skal sikre økonomiske incitamenter til at øge omkostningseffektiviteten, men uden at effekt indgår som et tildelingskriterie. Vi skitserer grundprincipperne i en effektbaseret tildelingsmodel, idet vi dels viser, hvordan der indbygges direkte incitamenter i tildelingsmodellen, og dels diskuterer, hvilke betingelser der skal være opfyldt, for at direkte effektbaserede tildelingsmodeller kan anvendes. Pedersens nye anerkendelsespraksis, der adresseres i den anden artikel i dette nummer.
Indonesian Consumers’ Intention of Adopting Islamic Financial Technology Services
Authors: Purwantini Anissa Hakim , Noor Athief Fauzul Hanif , Waharini Faqiatul Mariya
Published: September 2020

With the rise of Halal Lifestyle in the digital era, Islamic Financial Technology (henceforth FinTech) has increasingly become impactful to economic growth. Islamic FinTech companies are in a dire need to figure out factors that influence the adoption and acceptance of the technology to promote their business. Addressing the issue, this study examines consumers’ intention of using Islamic Fintech services. An online survey was employed to elicit the required data from 75 Indonesian consumers of Islamic FinTech services. The results of data analysis by means of SEM-PLS depicted that perceived usefulness and interpersonal influence were two key factors driving the consumers to use Islamic FinTech services. The results further revealed that compatibility positively influenced perceived usefulness and perceived ease of use, which in turn, affected the consumers’ attitude. Moreover, it was also noted that attitude and internet self-efficacy as perceived behavioral control in decomposition of theory of planned behavior had no significant impact on consumers’ intention. The results of this study theoretically provide a basic model of consumers’ intention in the context of Islamic FinTech. At the same time, FinTech industry users can use the results of the present study as references to come up with appropriate strategy to deal with the market needs.
Family in Top Management Team and Firm Value: Do Gender and Education of Family Manager Matter?
Authors: Sumarsono Hadi
Published: September 2020

The in-hand study sheds some light on empirical relationship between involvement of family members in the top management team and family firm value. Specifically, this study examines how gender and education of family managers affect firm value in Indonesian context. The total sample employed in this study consisted of 935 observations with 235 family companies. The data required in this study were collected from various sources. Drawing on fixed effect regression, the results identified that the involvement of family members in top management team significantly affected the family firm value. It was also revealed that the female family manager had a lower firm value than the male family manager. Moreover, the education level of the family manager positively affected the firm value. These results provide an empirical evidence on how gender and education of family managers influence family firm value. It is further depicted that the results of this study are in line with the upper echelons theory in which the differences in human resources (e.g. gender and education) arisen from the family involvement in a management undeniably affect family firm value. As for the practical contribution, this study suggests that powerful actors in the family firms should be a family member involved in a management. It is also a worth saying that the involvement of family members on the top management teams should consider gender and level of education.
The physicochemical properties of the deep eutectic solvents with triethanolamine as a major component
Authors: Djordjevic Biljana , Troter Dragan , Veljkovic Vlada , Kijevcanin Mirjana , Radovic Ivona , Todorovic Zoran
Published: September 2020

Different deep eutectic solvents (DESs) of triethanolamine (TEOA) and oxalic acid (OA), glacial acetic acid (AA), L-(+)-lactic acid (LA), oleic acid (OLA), glycerol (G), ethylene glycol (EG), propylene glycol (PEG), choline chloride (ChCl) or 1,3-dimethylurea (DMU) were prepared and characterized regarding their physicochemical (density, viscosity, electrical conductivity, refractive index, coefficient of volume expansion, molecular volume, lattice energy and heat capacity) properties over the temperature range of 293.15?363.15 K at 101.325 kPa. For all tested DESs, the density, viscosity and refractive index decreased with rising temperature, while the electrical conductivity increased. The temperature dependence of viscosity and electrical conductivity are described by the Vogel?Tamman?Fulcher equations. The viscosity and molar conductivity, which exhibited a linear behaviour, were correlated by the fractional Walden rule. Besides, the Fourier transform infrared spectroscopy (FTIR) was used to study the functional groups of these DESs while thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) provided the information about their stability. The tested DESs of TEOA possess desirable properties for use in various industrial processes, such as extractions, separations, chemical technology and biotechnology.
Association of Prodromal Type 1 Diabetes With School Absenteeism of Danish Schoolchildren: A Population-Based Case-Control Study of 1,338 Newly Diagnosed Children
Authors: Thingholm Peter R. , Gaulke Amanda , Eriksen Tine M. , Svensson Jannet , Skipper Niels
Published: September 2020

OBJECTIVE

To investigate school absenteeism before the clinical diagnosis of type 1 diabetes in children who develop the disease.

RESEARCH DESIGN AND METHODS

This population-based, retrospective case-control study involved all Danish children who developed type 1 diabetes and attended public schools (n = 1,338) from 2010 to 2017. Those children were matched at a 1-to-5 ratio, on the basis of sex and date of birth, to children without diabetes (n = 6,690). Case and control absenteeism were compared monthly, starting with 12 months prior to the type 1 diabetes diagnosis through 12 months after diagnosis.

RESULTS

Before the diabetes diagnosis (7–12 months), the mean number of days absent from school per month was 0.93 (SD 1.78) among children with diabetes and 0.93 (1.82) among control children (difference −0.004 days, P = 0.94). From 4 months before the diagnosis, children who developed diabetes had a statistically significant increase in absenteeism compared with control children (difference 0.24 days, P < 0.05).

CONCLUSIONS

Children who were diagnosed with type 1 diabetes had increased school absenteeism 4 months before diagnosis.
Pengaruh Rotasi Audit, Spesialisasi Industri KAP, dan Client Importance Terhadap Kualitas Audit (Studi dengan Pendekatan Earning Surprise Benchmark)
Authors: Suciana Maya Febrianti , Setiawan Mia Angelina
Published: September 2020

This research was aimed to examine empirically the effect of several factors to audit quality. These factors are Audit Rotation, Audit Firm Specialization and Client Importance. The population that will be used in this research are company listed in Indonesia Stock Exchange. This study uses sampel of 85 manufacturing companies listed in Indonesia Stock Exchange in the period 2015-2017. In this study, audit quality is measured by earning surprise benchmark. The method used was purposive sampling. The method of data analysis in this study use logistic regression with SPPS version 23. The results of this prove that (1) audit rotation is not proven to have an impact on audit quality, where sig value 0,915 > 𝛼 0,05 which means H1 is rejected (2) audit firm specialization is proven to have an impact on audit quality, where sig value 0,04 < 𝛼 0,05 which means H2 is accepted (3) client importance is not proven to have an impact on audit quality, where sig value 0,809 > 𝛼 0,05 which means H3 is rejected. The amount of Adjusted R is 0.036 gives the sense that rate is 3,6% of level audit quality can be explained by independent variables while 96.4% can be explained by the other independent variabels that are not tested in this study.Keywords: Audit Rotation, Audit Firm Specialization, Client Importance, Audit Quality
PKM Pelatihan Ekonomi Untuk Guru-Guru Anggota MGMP Ekonomi Kabupaten Tanah Datar
Authors: Taqwa Salma , Honesty Fiola Finomia , Serly Vanica
Published: September 2020

Teachers as professional educators are responsible as educators and instructors for their students. In order to work well, teachers must have appropriate competencies in the field of study they are teaching. Economic subjects in high school include the economics and accounting fields, which must be mastered by the teacher. The development of economics and accounting must be reached by the economics teacher who will transfer knowledge to their students. Besides that, the teacher's educational background will also affect student learning process. Training for high school economics teachers is needed to be able to increase the insight and knowledge of teachers. MGMP is one of the means for the teachers to draw and explore economics in order to be a professional teachers. From the results of the pretest and posttest, it can be concluded that there was an increasing in teacher knowledge generated from this training. It is expected that in the future MGMP will have a role in training and developing the knowledge of economics teachers in Tanah Datar.Keywords: economics, accounting, educational, teachers
Analisis Penerbitan Obligasi Daerah Sebagai Alternatif Pembiayaan Pembangunan Pada Pemerintah Provinsi Sumatera Barat
Authors: Yusesa Gusfina , Arza Fefri Indra
Published: September 2020

This study aims to analyze the ability and readiness of the issuance of municipal bonds in the government of West Sumatra Province as an alternative to development financing. This analysis includes the financial capability of the province of West Sumatra and the readiness in managing municipal bonds both in terms of human resources and preparation of regulations in the regions that have been carried out by the government of West Sumatra province. This study uses a descriptive qualitative approach interviewing 7 informants from several parties involved and having the authority in policy in the management of municipal bonds later in the government of West Sumatra province. The results showed that the government of West Sumatra province has the financial capability in issuing municipal bonds which is supported by the absence of regional provincial obligations in debt or other obligations. However, the results of the study found that the government of West Sumatra province does not yet have the readiness of human resources and the preparation of regulations in the implementation of municipal bonds. Keywords: Municipal Bond; Development Financing; Financial Capability; Human Resources and Regulation
Graduação em Computação no Brasil: perspectiva a partir do Exame Nacional de Avaliação de Desempenho
Authors: Silva Lidiane Cristina da , Campanelli Alexandre , Silva Liudimilla Santos da , Silva Thiago Vinicius Feltrin da , Silva Rosana Cordovil da , Garcia Ruth Del Raso , Magalhães Fábio Luís Falchi de
Published: September 2020

Considerando-se a expansão da graduação em Computação no Brasil, esse trabalho tem como objetivo analisar a série histórica desses cursos entre 2008 e 2014 de acordo com o Exame Nacional de Avaliação de Desempenho (ENADE). Classifica-se de natureza exploratória e descritiva e abordagem quantitativa, a partir de pesquisa documental. Como principais resultados, destaca-se a Região Nordeste como mais profícua em notas de conceito ‘5’, crescendo também sua presença no ENADE. Destaque também para Paraíba e Sergipe, estados com melhor conceito ‘5’. Ademais, as instituições públicas se destacam perante as privadas, enquanto os maiores cursos do país são: Sistemas de Informação, Ciência da Computação e Tecnologia em Análise e Desenvolvimento de Sistemas.
Consumer Behaviour Towards Vietnamese Online Shopping Websites in the Covid-19 Pandemic
Authors: Ha Nguyen Thu , Luong Thuy Hoang Dam
Published: September 2020

The theory of planned behaviour (TPB) was applied in this research in order to evaluate the influences of three factors including attitude, subjective norm and perceived behavioural control on online shopping purchase intention and behaviour towards websites in Vietnam. Data were collected from 170 online buyer in Vietnam, who responded willingly and fully to a questionnaire-based survey through Google Drive. The analysis results show that all three factors have positive impact on customer’s online purchase intention and behaviour in the Covid-19 pandemic. Especially, attitude is considered to have the greatest effects, followed by subjective norm and then perceived behavioural control that impacted on consumer shopping intention. In addition, the research also proposed some implications to diversify Covid-19 propagandas, encourage people using online shopping as well as support them in daily life during Covid-19 pandemic.
FAKTOR KEGAGALAN PEMEKARAN KECAMATAN MANDAU KABUPATEN BENGKALIS MENJADI DAERAH OTONOM
Authors: Episabri Erman
Published: September 2020

Faktor Kegagalan Pemekaran Kecamatan Mandau Kabupaten Bengkalis Menjadi Daerah Otonom memperlihatkan bahwa, adanya berbagai penghambat untuk daerah tersebut mendapatkan status sebagai Daerah Otonomi Baru di Riau. Pada dasarnya persoalan yang jadi penghambat tersebut ialah, persoalan regulasi yang berkepanjangan dan sekaligus ada upaya dari Kabupaten Bengkalis menghalangi Kecamatan Mandau. Unsur politik tidak terelakkan dengan mempengaruhi elit-elit yang notabenenya pejuang Kecamatan Mandau ini dengan berbagai posisi jabatan guna untuk membungkam aktor-aktor pejuang pemekaran tersebut. Kecamatan Mandau merupakan sebuah daerah yang memiliki sumber daya alam yang berlimpah, sehingga pada usulan pemekaran daerah ini terjadi tarik ulur antara pemerintah daerah dengan masyarakat yang menginginkan pemekaran tersebut. Usulan pemekaran ini sudah berlangsung sejak lama, dimulai pada tahun 1997, proses memanas puncaknya pada tahun 2007 hingga saat ini.
Waldemar Henrique e Gentil Puget: “Folk-lore” amazônico e modernismo musical
Authors: Da Silva Edilson Mateus Costa
Published: September 2020

O presente texto discute os aspectos referentes ao debate folclorista no âmbito do modernismo brasileiro e os aspectos regionais. Neste caso será abordada a relação entre as concepções de modernismo musical elaborada por Mário de Andrade e Heitor Villa-Lobos e como estiveram presentes em uma vertente amazônica. Para este objetivo nos deteremos na reflexão e análise das representações sobre as obras dos artistas paraenses Waldemar Henrique e de Gentil Puget. As estilizações folclóricas compostas e popularizadas por esses artistas foram importantes para as representações sobre a Amazônia. Não podemos desconsiderar a presença de Waldemar Henrique e Gentil Puget em meios de comunicação como o rádio, em apresentações em diferentes estados brasileiros ou no diálogo com outros folcloristas, a quem se revelavam fontes para suas representações, ou mesmo informantes. Foram significativos para a configuração do imaginário sobre a Amazônia e, consequentemente, sobre o Brasil.
O conflito jornalístico na construção identitária de Juazeiro
Authors: Patrício Edgard , Queiroz Cícero Dantas
Published: September 2020

O presente trabalho analisa um acontecimento histórico ocorrido na região do Nordeste do Brasil. Trata-se do fenômeno do padre Cícero e o processo de formação do território de Juazeiro do Norte (Ceará-Brasil), vislumbrado pelos jornais Correio do Cariry (1904 - 1912), do Crato (CE), e O Rebate (1909 – 1911), de Juazeiro do Norte (CE). A partir da análise de artigos veiculados entre 1909 e 1911, refletimos como o discurso jornalístico contribuiu no processo de constituição de novas representatividades e identidades (Bhabha, 1998; Hall, 2003, 2007; Woodward, 2007) do antigo povoado de Juazeiro, no período em que buscou sua independência política da cidade do Crato.
A “great priest of civilization”: Reinterpreting Victor Meirelles’ A Primeira Missa through newspapers
Authors: Oliveira Genaro
Published: September 2020

Using newspapers as primary sources, this article presents an innovative analysis of Victor Meirelles’ A primeira missa no Brasil (1860). Beyond canonical interpretations of Meirelles’ work as an erudite depiction of the beginning of Brazil’s history in 1500, the article demonstrates that for viewers of that time the painting also, and above all, represented the beginning of the history of Brazilian art in the 1800s. It demonstrates this by following general art debates in newspapers of the period, specifically in the years before and after the highly anticipated return of the young Meirelles from his European sabbatical. Debates in the press illustrate how Meirelles’ significance for nineteenth-century audiences in particular, and for Brazilian art history as whole, can only be fully decoded by situating the artist within Brazilian elites’ political-intellectual efforts to achieve European-style civilisational progress during the first decades of the post-independence period.
“Eva Moderna”: Representações de gênero em periódicos dos anos 1920: um olhar transnacional
Authors: Gorberg Marissa
Published: September 2020

Neste artigo visamos empreender uma análise entrecruzada de representações gráfico-satíricas publicadas em periódicos dos anos 1920, como prisma privilegiado para divisar ideias que permeavam as construções de gênero no circuito da mídia impressa nos dois lados do Atlântico.

Sob uma perspectiva da História Cultural, vislumbramos esse viés de investigação a fim de perscrutar circularidades transnacionais porventura evidenciadas nas temáticas e nos significados polissêmicos das representações, entendidas como repositórios de vestígios valorosos de arquétipos femininos, passíveis de interpretação.

Por meio de caricaturas, é possível entrever o papel dos periódicos na internacionalização da cultura e na elaboração de subjetividades; interessa-nos compreender a influência daqueles veículos nas mudanças de comportamento, nas demandas e aspirações das mulheres e consequente alteração de seu lugar social, em meio à difusão de gostos e valores, sensibilidades e imaginários, compartilhados em produções que conjugavam imagem, texto e humor.
Mechanism of the Highly Effective Peptide Bond Hydrolysis by MOF808 Catalyst Under Biologically Relevant Conditions
Authors: Conic Dragan , Pierloot Kristine , Parac-Vogt Tatjana , Harvey Jeremy
Published: September 2020

Efficient and selective hydrolysis of inert peptide bonds is of paramount importance. MOF-808, a metal-organic framework based on Zr6 nodes, can hydrolyze peptide bonds efficiently under biologically relevant conditions. However, the details of the catalyst structure and of the underlying catalytic reaction mechanism are challenging to establish. By means of DFT calculations we first investigate the speciation of the Zr6 nodes and identify the nature of ligands that bind to the Zr6O8H4-x core in aqueous conditions. The core is predicted to strongly prefer a Zr6O8H4 protonation state and to be predominantly decorated by bridging formate ligands, giving Zr6(μ3-O)4(μ3-OH)4(BTC)2(HCOO)6 and Zr6(μ3-O)4(μ3-OH)4(BTC)2(HCOO)5(OH)(H2O) as the most favorable structures at physiological pH. The GlyGly peptide can bind MOF in several different ways, with the preferred structure involving coordination through the terminal carboxylate analogously to the binding mode of formate ligand. The pre-reactive binding mode in which the amide carbonyl oxygen coordinates the metal core lies 7 kcal higher in free energy. The preferred reaction pathway is predicted to have two close-lying transition states, either of which could be the rate-determining step: nucleophilic attack on the amide carbon atom and C-N bond breaking, with calculated relative free energies of 31 and 32 kcal/mol, respectively. Replacement of formate by water and hydroxide at the Zr6 node is predicted to be possible, but does not appear to play a role in the hydrolysis mechanism.
Degradation of Pharmaceuticals Through Sequential Photon Absorption and Photoionization – the Case of Amiloride Derivatives
Authors: Jorner Kjell , Rabten Wangchuk , Slanina Tomas , Proos Vedin Nathalie , Sillén Sara , Wu Ludvigsson Jufang , Ottosson Henrik , Norrby Per-Ola
Published: September 2020

Photodegradation of pharmaceutical and agrochemical compounds is an important concern for health and the environment. Amiloride derivatives undergo clean photosubstitution in protic solvents. We have studied this apparent photo-SNAr reaction with a range of experimental and computational techniques. Available evidence points to a mechanism starting with photoexcitation followed by absorption of a second photon to eject an electron to give a radical cation intermediate. Subsequent substitution reaction with the protic solvent is assisted by a general base, possibly strengthened by the proximal solvated electron. Final recombination with the solvated electron generates the observed product. Quantum chemical computations reveal that excited state antiaromaticity is relieved when an electron is ejected from the photoexcited molecule by the second photon, leading to a weakly aromatic radical cation. The mechanism indicated here could have wide applicability to photoinduced degradation of similar heteroaromatic compounds in the environment as well as in protic solvents. There are also strong similarities to a class of increasingly popular synthetic photoredox methods.
Antiproliferative, cholinesterase and phosphodiesterase inhibitory activity of the DCM sub-extract of Uvaria alba: In vitro and in silico perspectives
Authors: Quimque Mark Tristan J. , Notarte Kin Israel R. , letada arianne , Fernandez Rey Arturo T. , Pueblos Kirstin Rhys S. , Pilapil Delfin Yñigo H. , Agbay Jay Carl M. , Dahse Hans-Martin , Wenzel-Storjohann Arlette , Tasdemir Deniz , Khan Abbas , We Dong-Qing , Macabeo Allan Patrick G.
Published: September 2020

Aims: To evaluate the in vitro antiproliferative, anticholinesterase and anti-phosphodiesterase activities of the sub-extracts of Uvaria alba (family Annonaceae) and explore putative binding mechanisms of its chemical constituents in silico.

Main methods: U. alba sub-extracts, obtained by solvent-solvent partition, were subjected to antiproliferative and cytotoxicity screening against chronic myelogenous leukemia (K-562) and human cervical cancer (HeLa) cells, respectively. Inhibitory assays against acetylcholinesterase (AChE) and phosphodiesterase (PDE4 B2) enzymes were also performed. The dichloromethane sub-extract (UaD) was chemically profiled using LC-HR-ESIMS-QToF to identify secondary metabolites 1–18. Molecular docking and molecular dynamics simulations were performed to determine the affinity of the putatively annotated metabolites against PDE4 B2B, AChE, ubiquitin specific peptidase 14 (USP14), and Kelch-like ECH-associated protein 1 (Keap1). In addition, DFT calculations were also performed to demonstrate Michael addition reaction between electrophilic cytotoxic metabolites and Cys151 of the Keap1-BTB domain.

Key findings: UaD showed antiproliferative and cytostatic activities against K-562 and HeLa, respectively, and inhibitory activities against AChE and PDE4 B2. Meanwhile, its polyphenolic constituents 3-(3,4-dihydroxybenzyl)-3’,4’,6-trihydroxy-2,4-dimethoxychalcone (8) and grandifloracin (15) showed favorable binding to AChE and Keap1-BTB domain, respectively. The most electrophilic and kinetically stable grandifloracin (15), favorably formed a beta-addition adduct with the Cys151 of Keap1 via Michael addition. The top-ranked ligand-protein complexes attained dynamic stability at 50-ns simulations with high free energy of binding. The top-ranked compounds also conferred favorable in silico pharmacokinetic properties.

Significance: The study highlights the role of U. alba secondary metabolites as potential inhibitors against the aforementioned target proteins in an effort to discover new drug leads for cancer and Alzheimer’s.
A DNA Aptamer That Inhibits the Formation of Unliganded Receptor Dimer and Ligand-Independent Signaling in Cancer Cells
Authors: Eguchi Akihiro , Ueki Ayaka , Hoshiyama Junya , Kuwata Keiko , Nagatoishi Satoru , Tsumoto Kouhei , Ueki Ryosuke , Sando Shinsuke
Published: September 2020

Growth factor receptors are activated through dimerization by the binding of their ligands and play pivotal roles in normal cell function. However, in cancer cells, the overexpression of receptors often causes the formation of unliganded receptor dimers, which can be activated in a ligand-independent manner. Thus, the unliganded receptor dimer is a promising target to inhibit aberrant signaling in cancer. Here, we report an aptamer that inhibits ligand-independent receptor activation via preventing the formation of unliganded receptor dimer. By biasing the receptor monomer–dimer equilibrium to the monomer, this aptamer inhibited aberrant cell signaling caused by the unliganded receptor dimer. This work presents a new possibility of oligonucleotide-based therapeutics for cancer.
High Performance Core-Shell Ni/Ni(OH)2 Electrospun Nanofiber Anodes for Decoupled Water Splitting
Authors: Landman Avigail , Hadash Shabtai , Shter Gennady E. , Dotan Hen , Rothschild Avner , Grader Gideon
Published: September 2020

Large surface area porous electrodes prepared from electrospun Ni and Ni-Co fibers A Ni/Ni(OH)2 core/shell structure produced by galvanic cycling in alkaline media Electrodes with improved current density and charge capacity High efficiency decoupled water splitting with Ni/Ni(OH)2 redox mediator
Design and Validation of an Online Partial and Total Pressure Measurement System for Li-Ion Cells
Authors: Lundström Robin , Berg Erik
Published: September 2020

Online Electrochemical Mass Spectrometry (OEMS) is capable of monitoring both partial and total gas pressure of Li-ion cells. Herein, the development and validation of an OEMS system along with detailed calibration protocols and limits of detection sensitivity are showcased. A full cell based on LiCoO2/Graphite cell during overcharge to 4.9 V vs. Li/Li+ at 50 °C is investigated and the results are compared to LiCoO2/LiFePO4 and Graphite/LiFePO4 cells in order to differentiate between gases forming at the anode and cathode. The release of O2 from LixCoO2 (x < 0.4) during both charge and discharge demonstrates that its degradation is dependent on composition rather than potential. Combining partial and total pressure measurements provides a clear advantage when detailing major and minor gas reactions as well as when determining unaccounted gases. The methodology presented herein provides a technical basis for deeper understanding of degradation reactions in batteries and electrochemical systems alike.
A Quantitative Evaluation of Computational Methods to Accelerate the Study of Alloxazine-Derived Electroactive Compounds for Energy Storage
Authors: Zhang Qi , Khetan Abhishek , Er Süleyman
Published: September 2020

Alloxazines are a promising class of organic electroactive molecules for application in aqueous redox flow batteries. Preliminary studies show that structural modifications of alloxazines with electron-donating and/or -withdrawing functional groups help in tuning of their redox properties. High-throughput computational screening enables rational and time-efficient discovery of functional compounds. The effectiveness of high-throughput computational screening efforts is strongly dependent on the accuracy and speed at which the performance descriptors are estimated for a large pool of candidate compounds. Here, we performed a quantitative study to assess the performance of computational methods, including the forcefield based molecular mechanics, semi-empirical quantum mechanics, density functional based tight binding, and density functional theory, on the basis of their accuracy and computational cost in predicting the redox potentials of electroactive alloxazines. We compared the performances of various energy-based descriptors, including the redox reaction energy and the frontier orbital energies of the reactant and product molecules. We found that the lowest unoccupied molecular orbital energy of the reactant molecules is the best performing descriptor for the alloxazines, which is in contrast to other classes of molecules, such as quinones that we reported earlier. Importantly, we present a flexible in silico approach to accelerate both the singly and the high-throughput computational screening studies, therewithal considering the level of accuracy vs measured electrochemical data, that is principally applicable for the discovery of efficient, alloxazine-derived organic compounds for energy storage in aqueous redox flow batteries.
LCMS Measurement of Steroid Biomarkers Collected from Palmar Sweat.
Authors: Hyde Jacob , Runyon J. Ray
Published: September 2020

Human eccrine sweat contains numerous biomarkers which can provide information on health,performance, and aging. Non-invasive collection and measurement of biomarkers has becomeespecially important in recent times given viral outbreaks like SARS-CoV-2. In the current studywe describe a method of sweat collection from palmar surfaces in participants via surface captureusing glass beads and the resulting analysis of biomarkers from very low volumes of sweat usingliquid chromatography mass spectrometry with selected ion monitoring. Study participantsunderwent a cognitive and physical stress task with easy and hard conditions with sweat beingcollected after each task. Resulting analysis found a signal for 22 steroid biomarkers and wereport detailed information on selected biomarkers, given their applicability to timely real-worldexemplars, including cortisol, dehydroepiandrosterone, allopregnanolone, estrone, aldosterone,and 20a/b-dihydrocortisone.
Skin manifestations of covid-19 infection and peculiarities of dermatologic care of patients in the pandemic period
Authors:   Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus, Adaskevich Uladzimir P.
Published: September 2020

Текущая пандемия SARS-CoV-2 оказывает огромное влияние на дерматологическую практику: отсутствует определенность относительно исхода инфекции COVID-19 у пациентов с распространенными дерматозами, такими как псориаз, атопический дерматит, аутоиммунные буллезные заболевания; возрастает необходимость прямого участия дерматологов как в помощи пациентам с COVID-19, так и в поиске новых научных подходов к терапии дерматологических проявлений заболевания. Дерматологи во всем мире собирают данные о поражениях кожи, которые могут быть незамеченными симптомами COVID-19, включая кожные проявления в форме различных высыпаний. В статье представлены данные испанских врачей с описанием пяти разновидностей кожных манифестаций COVID-19, а также результаты российских исследователей о семи группах кожных высыпаний у пациентов с коронавирусной инфекцией COVID-19 в зависимости от их этиологии и механизмов развития. SARS-CoV-2 – новый высокозаразный патоген для человека, который может быстро распространяться и способен оказать огромное влияние как на состояние здоровья, так и на экономические и социальные факторы. Последствия COVID-19 могут сказываться еще долго после разрешения пандемии и привести к возникновению новых методов ведения дерматологических пациентов. Ключевые слова: воспалительные дерматозы, псориаз, атопический дерматит, аутоиммунные буллезные дерматозы, коронавирусная инфекцияCOVID-19. Для цитирования: Адаскевич В.П. Кожные проявления у пациентов с коронавирусной инфекцией COVID-19 и особенности работы дерматовенеролога в период пандемии. Consilium Medicum. 2020 (22); 7: 9–13. DOI: 10.26442/20751753.2020.7.200262
Panniculitis in the practice of an internist and a dermatologist (a lecture
Authors:   Nasonova Research Institute of Rheumatology, Moscow, Russia, Egorova Olga N. , Belov Boris S. ,   Nasonova Research Institute of Rheumatology, Moscow, Russia
Published: September 2020

Панникулиты представляют собой совокупность гетерогенных воспалительных заболеваний, протекающих с поражением подкожной жировой клет-чатки (ПЖК) и имеющих общие клинические и патоморфологические признаки. Частота панникулитов в разных регионах мира широко варьирует и зависит от распространенности того или иного заболевания, являющегося этиологическим фактором рассматриваемой патологии. В соответствии с преимущественным преобладанием воспалительных изменений в соединительнотканных перегородках (септах) или жировых дольках выделяют септальный и лобулярный панникулиты. Оба типа могут протекать с признаками васкулита и без такового. Клиническая картина панникулитов ха-рактеризуется уплотнениями разной окраски, сопровождающимися болью разнообразной интенсивности, с преимущественной локализацией на нижних конечностях. Изменения общепринятых лабораторных показателей при панникулитах носят неспецифический характер, как правило, от-ражая наличие и выраженность воспалительного процесса. Гистоморфологическое исследование биоптатов кожи, подкожной жировой клетчатки и фасции является «золотым стандартом» диагностики заболевания, особенно лобулярных форм. В процессе обследования может возникать ряд вопросов, связанных с дифференциальным диагнозом вариантов панникулита. Лечение панникулитов окончательно не разработано и проводится в основном с учетом терапии основного заболевания. Ключевые слова: панникулиты, диагностика, дифференциальный диагноз, лечение. Для цитирования: Егорова О.Н., Белов Б.С. Панникулиты в практике интерниста и дерматолога (лекция). Consilium Medicum. 2020 (22); 7: 78–83. DOI: 10.26442/20751753.2020.7.200288
The place of combined hormonal contraceptives in the therapy for acne in women
Authors:   Medical Center NEBOLIT, Moscow, Russia, Uspenskaya Yulia B.
Published: September 2020

Гиперандрогения играет значимую роль в патогенезе акне. Андрогены способствуют гиперплазии сальных желез, повышенной продукции кожного сала и гиперкератозу. Избыточные влияния андрогенов на кожу обусловлены гиперандрогенией на фоне различных эндокринных синдромов или повышенной чувствительностью рецепторов кожи к нормальным концентрациям мужских половых гормонов и локальной гиперпродукцией андро-генов. Применение комбинированных оральных контрацептивов (КОК) имеет терапевтический потенциал при лечении акне у пациенток с гипер-андрогенией и у женщин с нормальным уровнем андрогенов. Использование КОК может являться альтернативой системной терапии антибактери-альными препаратами и ретиноидами. Решение вопроса о назначении КОК пациенткам с акне должно приниматься совместно, при участии дерматолога, гинеколога или эндокринолога. Ключевые слова: угревая болезнь, гиперандрогения, андрогены, тестостерон, прогестины. Для цитирования: Успенская Ю.Б. Место комбинированных гормональных контрацептивов в терапии акне у женщин. Consilium Medicum. 2020; 22 (7): 69–72. DOI: 10.26442/20751753.2020.7.200308
The study on effect of home based pulmonary rehabilitation in chronic obstructive pulmonary disease
Authors: Kalaichandar M  , Kirubakaran K  , Baskaran V  , Kokila K  , Jeevitha M  , Ravichandran S
Published: September 2020

Chronic obstructive pulmonary disease(COPD) is a leadingcauseof mortality and morbidity globally (3 million deaths in 2012). COPD is common in older population and kills on average one person every 10 seconds. In 2002, COPD was the fifth leading cause of death. Total deaths from COPD are proposed to grow through more than 30% in the next 10 years. Estimations indicate that COPD in 2030 turns into the 0.33 main reason for the loss of life worldwide. The WHO estimate quotes a figure of almost 5,56,000 deaths attributable to COPD in the SoutheastAsian region, which majorly comprises India. The challenge in both treatment and prevention of COPD remains the same. Despite major improvement in health care particularly in the treatment of COPD, the mortality due to COPD tends to be high and is expected to increase in the future according to . Use intolerance is an individual and a disturbing appearance of the disease. Lack of physical activity in COPD patients contributes a major complication to the disease. Oral or inhaled medicine have incomplete role in cultivating the physical capacity of these patients. So the main aim of treatment is control of symptoms, decreasing exacerbation frequency and hospitalization rates, maximizing lung function, refining the quality of life and implementation capacity by means of pulmonary reintegration. Extensive search of literature has not revealed larger data on effect of pulmonary rehabilitation in management of COPD pertaining to South Indian population. Hence, the present study was undertaken to assess the effect of home based rehabilitation program in South Indian population.
PROSES KREATIF DAN KRITIK SOSIAL DALAM NOVEL BABAD NGALOR-NGIDUL KARYA ELIZABETH D. INANDIAK
Authors: Maulidina Bunga Hening , Suryanto Edy , Wardani Nugraheni Eko
Published: September 2020

This study aims to describe and explain the creative process of authors and social criticism found in Babad Ngalor-Ngidul novel. This research use desciptive qualitative approach. Data sources in the form of Babad Ngalor-Ngidul novels by Elizabeth D. Inandiak and author interviews and data collection were carried out by purposive sampling. Data were analyzed based on the author's creative process theory and literary sociology in the form of speech, sentence, or discourse contained in the data source. Data is filtered and classified according to research objectives, which are related to the creative process of authors and social criticism. The results of the study stated that there is a connection between the creative process of the author and social criticism in the Babad Ngalor-Ngidul novel. The author's creative process is based on the eruption and earthquake events in Yogyakarta, and is influenced by the interaction of the author with the community of Kinahrejo and Bebekan. The criticisms contained in the Babad Ngalor-Ngidul novel are social, cultural and political criticisms of the dynamics of post-disaster community change. The creative process of the author and the delivery of the message of criticism are intertwined in the moderate position of literature as a form of sanctification (catharsis), and healing.Penelitian ini bertujuan mendeskripsikan dan menjelaskan proses kreatif pengarang dan kritik sosial yang terdapat pada novel Babad Ngalor-Ngidul. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Sumber data berasal dari novel Babad Ngalor-Ngidul karya Elizabeth D. Inandiak dan hasil wawancara pengarang serta pengambilan data dilakukan secara purposive sampling. Data dianalisis berdasarkan teori proses kreatif pengarang dan sosiologi sastra yang berupa tuturan, kalimat, atau wacana yang terdapat dalam sumber data. Data disaring dan diklasifikasikan sesuai tujuan penelitian, yakni terkait dengan proses kreatif pengarang dan kritik sosial. Hasil penelitian mengemukakan bahwa terdapat kaitan antara proses kreatif pengarang dan kritik sosial yang ada dalam novel Babad Ngalor-Ngidul. Proses kreatif pengarang dilandasi atas peristiwa erupsi dan gempa di Yogyakarta serta dipengaruhi interaksi pengarang dengan masyarakat Kinahrejo dan Bebekan. Adapun kritik yang terdapat dalam novel Babad Ngalor-Ngidul adalah kritik sosial, budaya, dan politik atas dinamika perubahan masyarakat pascabencana. Proses kreatif pengarang dan penyampaian pesan kritik berkelindan dalam posisi moderat karya sastra sebagai bentuk penyucian (katarsis) serta penyembuhan.
RELASI KEKUASAAN DALAM WACANA KONFLIK KPK VS POLRI JILID II
Authors: Wasono Aji Endro Nugroho
Published: September 2020

Power relations are related to the power of individuals, groups, or institutions over individuals, groups, or other institutions. One party in this case tries to dominate the other party. The asymmetrical relationship is illustrated by the conflict between the Corruption Eradication Commission (KPK) and Indonesian Police (Polri) volume II. This was described in the editorial of Suara Merdeka daily newspaper. This paper discusses how the relations involved in the KPK versus Polri conflict volume II were discussed in the editorial of Suara Merdeka. To examine this relationship, qualitative content analysis methods are used. Qualitative content analysis is a method used to understand the message of a discourse. The relation in the KPK versus Polri conflict discourse volume II is described by Suara Merdeka editors by utilizing linguistic aspects in the form of vocabulary and grammar. Utilization of the vocabulary is in the form of the use of euphemisms and prominent formal words. Meanwhile, the use of grammar is in the form of interrogative sentence and per-sonal pronouns we/us. In describing this relation, the editor put the Polri institution in a dominant position, while the KPK institution was marginalized by the President and Polri institutions.Relasi kekuasaan berkaitan dengan kekuasaan individu, kelompok, atau institusi terhadap indivi-du, kelompok, atau institusi lainnya. Salah satu pihak dalam hal ini berusaha mendominasi pihak yang lain. Relasi yang asimetris tersebut tergambar dalam konflik KPK vs Polri jilid II. Hal terse-but dideskripsi dalam wacana “Tajuk Rencana” harian Suara Merdeka. Makalah ini membahas ba-gaimana relasi-relasi yang terjalin dalam konflik KPK vs Polri jilid II yang dibahas dalam “Tajuk Rencana” harian Suara Merdeka. Untuk mengkaji relasi tersebut digunakan metode analisis isi ku-alitatif. Analisis isi kualitatif adalah suatu metode yang digunakan untuk memahami pesan dari suatu wacana. Relasi dalam wacana konflik KPK vs Polri jilid II dideskripsikan oleh redaksi Suara Merdeka dengan memanfaatkan aspek kebahasaan yang berupa kosakata dan gramatika. Pemanfa-atan kosakata tersebut berupa penggunaan eufemisme dan kata-kata formal yang menonjol. Se-mentara itu, pemanfaatan gramatika berupa kalimat interogatif dan pronomina persona kita. Da-lam mendeskripsikan relasi tersebut, redaksi menempatkan institusi Polri pada posisi dominan, sebaliknya institusi KPK pada posisi yang dimarginalkan oleh institusi Presiden dan Polri.
THE ROLE OF FINANCIAL DEVELOPMENT AND INSTITUTIONAL QUALITY ON ENVIRONMENTAL SUSTAINABILITY IN SUB-SAHARAN AFRICAN COUNTRIES
Authors: Jibrilla Aliyu Alhaji
Published: September 2020

This study addresses the question of financial development and institutional quality influence on the environmental sustainability of some 13 countries from the sub-Saharan Africa. Relying upon pooled mean group (PMG) for panel data, we provide evidence which suggest that both financial development and institutional quality are statistically significant determinants of per capita carbon dioxide emissions in the region. More specifically, we found that without healthy institutions and sound financial system sub-Saharan African countries might not avoid environmental degradation experienced by advanced nations during their early stage of economic progress. Our results also support the EKC hypothesis in the region.  In addition, the paper also shows that more openness to FDI inflows is good for the environment across the SSA. These findings suggest the need for institutional and financial service reform that supports robust environmental conservation.