bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Monitoring Glucocorticoid Receptor in Plasma-derived Extracellular Vesicles as a Marker of Resistance to Androgen Receptor Signaling Inhibition in Prostate Cancer
Authors: Gentile Emanuela , Hahn Andrew W. , Song Jian H. , Hoang Anh , Shepherd Peter D. A. , Ramachandran Sumankalai , Navone Nora M. , Efstathiou Eleni , Titus Mark , Corn Paul G. , Lin Sue-Hwa , Logothetis Christopher J. , Panaretakis Theocharis
Published: December 2023

Cellular and EV RNA integrity
FIGURE 4 from Monitoring Glucocorticoid Receptor in Plasma-derived Extracellular Vesicles as a Marker of Resistance to Androgen Receptor Signaling Inhibition in Prostate Cancer
Authors: Gentile Emanuela , Hahn Andrew W. , Song Jian H. , Hoang Anh , Shepherd Peter D. A. , Ramachandran Sumankalai , Navone Nora M. , Efstathiou Eleni , Titus Mark , Corn Paul G. , Lin Sue-Hwa , Logothetis Christopher J. , Panaretakis Theocharis
Published: December 2023

Effect of ENZA on GR in EVs in MDA PCa 322-2-6a tumors in vivo (PDX model). Schema and treatment planning for in vivo experiment with MDA PCa 322-2-6a tumors. A, Tumor volume after 14–21 days of treatment in vehicle group and ENZA-S and ENZA-R (ENZA-S vs. vehicle, *, P = 0.0019); qRT-PCR for GR in VEHICLE (n = 8; 14 days vs. BL), ENZA-S group (n = 5; 14 days vs. BL, *, P = 0.0479) and ENZA-R group (n = 5; 14 days vs. BL, ***, P = 0.0003). B, Final tumor growth analysis of VEHICLE group (n = 8) and ENZA-R (n = 5) and ENZA-S group (= 5; ENZA-R vs. vehicle, **, P = 0.0075), (ENZA-S vs. vehicle, ***, P = 0.0002), (ENZA-R vs. ENZA-S, ****, P ≤0.0001). Comparison of qRT-PCR results of GR between ENZA-R and ENZA-S and BL (ENZA-R vs. BL, **, P = 0.0063; ENZA-S vs. ENZA-R,**, P = 0.0015).
FIGURE 2 from Monitoring Glucocorticoid Receptor in Plasma-derived Extracellular Vesicles as a Marker of Resistance to Androgen Receptor Signaling Inhibition in Prostate Cancer
Authors: Gentile Emanuela , Hahn Andrew W. , Song Jian H. , Hoang Anh , Shepherd Peter D. A. , Ramachandran Sumankalai , Navone Nora M. , Efstathiou Eleni , Titus Mark , Corn Paul G. , Lin Sue-Hwa , Logothetis Christopher J. , Panaretakis Theocharis
Published: December 2023

GR knockdown in vitro.A, Immunoblot analysis of the indicated proteins in LNCaP (LREX were used as GR expression control) cells after transduction with shGR-2 (GR−). qRT-PCR for GR (GR− vs. CN, *, P = 0.0143; GR− vs. SCR, *, P = 0.0276). B, LNCaP cells count (GR− vs. CN, *, P = 0.0341; GR− vs. SCR, **, P = 0.0036) and MTS after knockdown. C, Comparison of GR expression in cells and EVs derived by immunoblot analysis and qRT-PCR of GR expression. D, Immunoblot analysis and qRT-PCR of GR expression on LNCaP cell GR knockdown (GR−) after treatment for 5 days with 1 µmol/L ENZA.
Vaccines in Long-Term Care Settings: A Narrative Review
Authors: Frangos Emilia , Barratt Jane , Michel Jean-Pierre , Ecarnot Fiona
Published: December 2023

Background: Older people living in long-term care facilities represent a particularly vulnerable segment of the population, who disproportionately bear the burden of infectious diseases, as recently highlighted by the COVID-19 pandemic. Summary: Older long-term care residents typically cumulate several risk factors for infection and experience serious life-threatening outcomes once infected. These common infections are often compounded by the collective living environment, where it is more difficult to contain the spread of infection. Moreover, the staff may represent an additional reservoir of potential infection and mode of transmission. In this paper, we review the burden of infectious respiratory diseases in residents in long-term care and discuss the potential gains from higher vaccine coverage in this older and most vulnerable population but also from higher vaccine coverage among the facility staff. We highlight the compelling need to integrate specific vaccine recommendations for residents of long-term care into national vaccination schedules, as well as the need to include vaccination campaigns in routine protocols for infection control. Surveillance, reporting, hygiene, and individual protective measures remain key aspects in basic infection control, both in ordinary times and during epidemics. Key Message: Vaccination of residents in long-term care facilities against respiratory diseases including influenza, pneumococcal disease, pertussis, and COVID is a simple, inexpensive, and effective means to reduce the burden of infection in this segment of the population.
Paediatric Rhabdoid Meningioma: Clinical and Therapeutic Features Findings – Case Series of 3 Patients
Authors: Gader Ghassen , Slimane Abdelhafidh , Sliti Firas , Badri Mohamed , Zammel Ihsèn
Published: December 2023

Introduction: Paediatric rhabdoid meningioma (RM) is the rarest but most aggressive subtype of meningioma, related to a severe prognosis. They account for 1–3% of all intracranial meningiomas. Case Presentations: We report an institutional experience of 3 cases through which we discuss clinical, histological, and therapeutic features of this tumour. Two of our patients were female-gendered (3 years old and 1 year and 6 months old), and one was male-gendered (16 years old). Revealing symptoms were related to intracranial hypertension, cerebellar syndrome, cranial nerve palsy, and skull tumefaction. Imaging showed extra-axial tumour located in the right ponto-cerebellar angle in the first case, in the left occipital region in the second case, left parietal tumour in the third case. All patients underwent a surgical intervention with a gross total resection. Histological evaluation supported by immunohistochemistry confirmed the diagnosis of RM. Tumour recurrence was observed at 45 days in the first case with a fatal outcome. Despite adjuvant radiotherapy, both second and third cases had local recurrence after a mean follow-up of 1 month following the radiotherapy. Conclusions: RM is very aggressive tumours. Standardized therapeutic guidelines are still under debate as actual approaches are still inefficient to prevent quick recurrence and fatal outcome.
Frequency response of microgrids with PV power generation and energy storage system (battery and supercapacitor)
Authors: Hamzah Abdullah Alaa , M. Al-Anbary Karrar , Mahdi Hamad Qasim , Ali Al Abboodi Hanaa Mohsin , Taih Gatte Mohammed
Published: December 2023

Since renewable energy sources (RES) have almost little inertia, an increase in their electricity might harm the power system's ability to run steadily and dependably. Numerous solutions to the issue mentioned above are offered. This paper aims to assess the technological possibility of using energy storage system (ESS) devices built from batteries and supercapacitors to enhance the interia response of sources in microgrids with a large amount of PV power penetration. The microgrid's inertia was altered by varying the penetration level of RES. To obtain a rigid microgrid, batteries and supercapacitors are suggested in this study to enhance frequency stability and droop control is utilized to complete this assessment. The model of the on-grid power network was designed using Simulink in MATLAB to evaluate the high level of RES penetration impact on the frequency stability of the system. Results verify that the microgrid stiffness is significantly enhanced when the suggested storage elements are incorporated. The findings show that the rate of change of frequency (RoCoF) is reduced when the size of the ESS increases and vice versa. The supercapacitor energy storage system (SCESS) can increase the stability of the system's frequency more effectively than the battery energy storage systems (BESS) with a slower time response.
A deep learning based architecture for malaria parasite detection
Authors: Alraba'nah Yousef , Toghuj Wael
Published: December 2023

During last decade, medical imaging has attracted great deal of research interests. Deep learning applications has revolutionized medical image analysis and diseases diagnosis. Convolutional neural networks (CNNs)-a class of deep learning-have been widely used for classification and feature extraction, and they revealed good performance for various imaging applications. However, despite the advances in medicine, malaria remains among the world’s deadliest diseases. Only in 2020, malaria recorded 241 million clinical episodes, and 627,000 deaths. The disease is examined visually through a microscope, which depends on the pathologists experience and skills and results may vary in different laboratories. This paper proposes an efficient CNN architecture that could be used in diagnosing of malaria disease. By processing on 27,558 red blood smear cell images with balanced samples of parasitized and unparasitized cells on a publicly available malaria dataset from the National Institute of Health, the proposed model achieves high accuracy rate with 99.8%, 98.2, and 97.7% for training, validation and testing sets. Furthermore, the statistical results approve that the proposed model is outperforming the state-of-the-art models.
An extended sensor fault tolerant control method applied to three-phase induction motor drives
Authors: Huu Nguyen Minh Chau , Tran Cuong Dinh
Published: December 2023

This research presents a fault tolerant (FT) control method for three-phase induction motor drives (IMDs) against sensor failures in the operating process. In this paper, an IMD applied the field oriented (FO) control for the speed and torque control is used to study the operation under sensor fault conditions. A fault detection isolation function is integrated into the FO control loop as an intermediary component to evaluate the quality of the measured signals of the sensors and provide proper signals for speed control of the drive system. A combined method of a comparison algorithm and a third difference operator (TDO) is proposed for the fault diagnosis function to improve the sustainable operation of the drive. The reliability of the proposed method will be verified through the operation mechanism of the FT function corresponding to three sensor fault states and a random noise state in the simulation environment by MATLAB/Simulink software.
Effect of shunt reactor rating on the switching transients overvoltage in high voltage system
Authors: Al-Tak Mazyed A. , Ain Mohd Fadzil , Al-Yozbaky Omar Sh. , Mohd Jamil Mohamad Kamarol
Published: December 2023

This paper includes a computer simulation of switching transient overvoltages during the disconnecting of shunt reactors (SR). Based on the results of the transient simulations, two reactors (150 MVAr and 50 MVAr) were examined. Reactor current interruption causes significant overvoltages, especially across the reactor and the circuit breaker (CB). The severity of these overvoltages may surpass the voltage level, which might endanger the reactor’s insulation and accelerate the CBs ageing process. For this reason, a significantly modified circuit model is proposed. The results of the field testing showed that the proposed modified circuit technique was successful. The transient overvoltages were computed using ATP-draw simulations of the equivalent circuit during switching. Successful synchronous switching could decrease the electromagnetic and mechanical stress generated during frequent switching operations. The model was examined the switching transient overvoltage for different values of current chopping (0-20) A. The proposed model proved that the reduction of the overvoltage was 86% in case of (50 MVAr) shunt reactor rating and 87% in case of (150 MVAr) shunt reactor rating.
The effect of FeNi-AlN layer thickness on the response of magnetic SAW sensor by FEM simulation
Authors: Phu Do Duy , Hoang Hong Si , Van Vinh Le
Published: December 2023

In this study, we used simulation to investigate the optimal working point of a surface acoustic wave-magnetostriction sensor by varying the thickness of the magnetic sensitive layer using the finite elements method. We evaluated the sensor’s sensitivity by simulating the responses at the optimal point and changing the thickness of the magnetic sensitive layer (h3). Additionally, we reduced the piezoelectric substrate thickness (h1) at the optimal point to determine the limit point of the center frequency (f0) and improve the sensor sensitivity for low magnetic field intensity measurements by performing a wavelength reduction (λ). For the simulation, we selected a delay-line FeNi/IDT/AlN structure with specific materials and electrode parameters. Our results show that the optimal structure of the sensor is at h1=400 μm, λ=40 μm, and h3=1,060 nm, with a maximum f0 of 140.38493 MHz and maximum surface acoustic wave velocity of 5,615.4 m/s. At this optimal structure, the sensitivity reaches the maximum value of 10.287 kHz/Oe with a working range from 0 to 89 Oe. We also found that reducing the piezoelectric substrate thickness to 35 μm significantly reduces the manufacturing and simulation time, but the frequency response cannot determine the center frequency.
Automated lighting design in the classroom
Authors: Widya Pratama I Putu Eka , Soehartanto Totok , Ari Wibowo Daniel Dany , Tjandra Nabiilah Aziizah , Nizar Mochammad
Published: December 2023

Lamp automation is utilized to adjust the lighting in the classroom by adjusting to the level of sunlight intensity outside the classroom. The light intensity will be adjusted to the utilization of lights as indicated by the need to enlighten a room. Therefore, this research aims to depict the design of a light intensity measurement system using a BH1750 sensor that will be carried out to measure the intensity of sunlight in units of light (lux). The signal from the sensor will be transmitted to a mini pc which functions to process measurement data and display it on the graphical user interface (GUI). As a result, the sensor will instruct the dimmer as an actuator to control the classroom lights according to the lighting from the sun. This system is already installed in the classroom and can save energy around 35 kWh a year.
Flipped classroom with collaborative learning approach in enhancing writing skills of Indonesian university students
Authors: Kheryadi Kheryadi , Suseno Muchlas , Lustyantie Ninuk
Published: December 2023

The intention of this study was to examine how a flipped classroom with a collaborative learning approach improved the writing skills of Indonesian higher education students. To achieve the study’s aim of 48 Indonesian higher education participants, the Oxford Quick Placement Test (OQPT) was employed. They were divided into two groups: experiment and control. Following that, as a pre-test, both groups were given a written exam. The experimental class (EC) was then positioned in a flipped classroom. Students were permitted to bring smartphones to class and utilize them while learning, and the flipped classroom was equipped with an internet connection, a laptop, and a projector. The control class (CC) got standard classroom instruction. This strategy was employed until the very last session. The experimental group outperformed the control group on the post-test, according to the results of the independent samples t-test and one-way analysis of covariance (ANCOVA). Furthermore, the results revealed a significant difference in post-test performance between the EC and CC.
Validation of the French version of the classroom assessment scoring system infant and toddler in Quebec
Authors: Lemay Lise , Hayotte Paul , Lemire Julie , Bouchard Caroline , Brault-Foisy Lorie-Marlène , Bigras Nathalie , Cantin Gilles
Published: December 2023

The objective of this study is to validate the French version of the Classroom Assessment Scoring System (CLASS) infant and toddler, as employed to assess the quality of interactions in groups of children under 3 years old, in childcare centers in Quebec where French is the official language. Indeed, when using a different language version of a standard-based tool outside its original context, an important step is to verify that it remains reliable and valid for measuring the research construct. This validation study was conducted in Montreal area (Quebec, Canada). The subjects were 154 classrooms (46 infant, 108 toddler) located within a representative sample of 68 childcare centers. Live classroom observations were conducted in the fall 2018 with the CLASS and other measures of process quality. Results replicate the factor structures of the original versions of the CLASS tool and provide evidence for the good reliability (inter-rater reliability, internal consistency) and validity (criterion and construct) of the French versions. The discussion highlights cross-cultural differences in the classrooms, childcare centers, and regulations that could explain some differences obtained in this research and, therefore, needs to be considered when using the CLASS in French to have a reliable and valid tool to measure the quality of interactions.
Exploring elementary teacher education students’ perception on parental involvement
Authors: Yosef Yosef , Rozzqyah Fadhlina
Published: December 2023

This study concerned with elementary teacher education students not prepared to have competency in parental involvement in education. The research aimed to explore their perceptions of the importance of parental involvement in elementary education. A 30-item online survey questionnaire, which employed a series of Likert-style statements in five types of parent involvement, was utilized to measure their perceptions. The study involved 1,459 undergraduate students majoring in elementary teacher education as participants, representing 72 study programs of universities and college schools in Indonesia. Descriptive and mean score comparison analyses were employed to make the obtained data meaningful. The finding revealed that the students rated parental involvement as an urgent aspect of elementary school education. The study discovered no significant difference between male and female students, significant differences among sophomore, junior, and senior students, and significant differences among students of public and private higher education institutions. The findings indicated that all respondents agreed on the importance of involvement and revealed implications for the elementary education study program.
Eco-pesantren modeling for environmentally friendly behavior: new lessons from Indonesia
Authors: Aulia Rihlah Nur , Abbas Hafid , Nurhattati Nurhattati , Jasin Faisal M. , Mushlihin Mushlihin
Published: December 2023

Pesantren or Islamic boarding school plays a vital and strategic role in improving environmentally sound education. Eco-pesantren is a movement that puts a high concern for the environment. This study aimed to analyze eco-pesantren modeling techniques in education. It is a case study with a qualitative research method. The research was conducted at Islamic Boarding School Sumber Mental Agama Allah (SPMAA), Turi Lamongan, East Java, Indonesia. Data were collected by observation, interviews, questionnaires, and document studies. This research concluded that modeling techniques can at least be pursued in four main ways: the individual role model of pesantren leaders; infrastructure and their use; governance systems; and culture or traditions. Besides, using integrated modeling techniques at both school and pesantren culture can increase insight and application of environmentally friendly behavior through a direct observation and habituation of healthy educational practices. Modeling can help students turn abstract ideas of green life into actual implementations. Direct observation of continuous practices equips students with the knowledge required to perform expected behaviors. Research on modeling assists eco-pesantren institutions encourage learning and practices about healthy environment. In the global context, it can be a role model for the implementation of environmentally friendly education that promotes environmentally sound learning.
Context input process product evaluation of hybrid learning practices in Indonesian universities
Authors: Suryanto Adi , Aman Aman , Yuliana Lia , Purwanto Nurtanio Agus , Firdaus Fery Muhamad , Fadhli Rahmat
Published: December 2023

The transformation of post-pandemic learning at Indonesian universities is becoming increasingly diverse. Several universities use hybrid learning models to implement hybrid learning practices. The purpose of this study is to assess the hybrid learning process at two Indonesian universities. The context input process product (CIPP) evaluation model is used in this study as part of a mixed method. Quantitative methods are used to get an overview of student and lecturer responses, whereas qualitative methods are used to dig deeper into data about hybrid learning practices. This study included 341 students and 22 lecturers from both universities. Techniques for collecting data include questionnaires, interviews, observation, and documentation studies. The data was analyzed using learning theories. The study’s findings indicate that hybrid learning practices are performing well. The readiness of university infrastructure, as well as the readiness of students and lecturers, determines the success of hybrid learning implementation. In practice, however, some lecturers tend to use face-to-face or online learning practices exclusively to fill gaps in the hybrid learning process. This study suggests that universities investigate an effective model for implementing hybrid learning.
Technological, pedagogical, and content knowledge for technology integration: a systematic literature review
Authors: Sofwan Muhammad , Yaakob Mohd Faiz Mohd , Habibi Akhmad
Published: December 2023

Many empirical studies used technological, pedagogical, and content knowledge (TPACK) to evaluate technology integration in education. However, systematic reviews on TPACK, related to technology integration in education are still limited, linked to the TPACK and technology integration issue. Therefore, this systematic literature reviews TPACK-based studies from 2010 to 2022, focusing on three topics: instruments to assess TPACK, TPACK domains’ inter-correlation, and TPACK relationships with technology integration. This systematic literature review implemented PRISMA (preferred reporting items for systematic reviews and meta-analyses). The study used Science Direct as a platform for articles’ search with three keywords, namely TPACK, preservice teacher; TPCK, preservice teacher; and TPACK, preservice teacher, technology integration. There were 28 articles reviewed. The findings informed 11 articles regarding scales to assess TPACK. There were nine articles reported TPACK domains’ intercorrelation and 10 articles informed TPACK relationships with technology integration. This study could significantly contribute to advancing knowledge regarding instruments to assess TPACK, TPACK factors inter-correlation, and TPACK and technology integration.
Design thinking aplicado ao reprojeto de serviços bibliotecários: um levantamento bibliográfico (1963-2015)
Authors: Andrade Vania Coutinho Gomes , Silva Guido Vaz
Published: December 2023

The service sector underwent important developmental changes in the last decade. Contemporary life has produced increasingly demanding and participative customers regarding the service creation process. As such, companies turned towards new methodologies or instruments to expand their innovation strategies. Thus, as libraries are organisms that deliver informational services, it becomes opportune to evaluate and analyze their users’ impressions, expectations and needs, as well as to identify the librarians’ experiences, motivations and frustrations. This bibliographic survey, conducted on the Portal de Periódicos Capes, seeks to understand the Design Thinking approach used as an innovation principle and potential tool for redesigning library services, based on articles considered relevant by the number of citations in the literature.
Normativas para classificação e descrição arquivísticas: uma análise das resoluções do CONARQ (1995-2021)
Authors: Linden Leolíbia Luana , Vital Luciane Paula
Published: December 2023

Classification and archival description are considered processes of organization and representation of knowledge and information. This study analyzes the characteristics of the classification processes and the archival description provided for in the regulations in the area of ​​Archivology. It is characterized as exploratory and descriptive research. As for the methodological procedures, it is a documentary research and uses Bardin's content analysis. The corpus of the analysis are the resolutions of the National Archives Council (CONARQ); Among the resolutions, through analysis of structure and content, ten were selected that directly address the themes of archival classification and description. It carries out a horizontal analysis, linked to the classification and description observations in each of the normative instruments, while the vertical analysis seeks to define standard categories for the classification and description of these instruments. Content analysis developed the formulation of fifteen categories for classification and eight for description. In the resolutions that deal with archival classification, we see the endorsement of governance initiatives that encompass the activities and stages that factually implement the practice and development of classification in different organizational environments. As for the resolutions that deal with archival description, we have a scenario dominated by the use of models and standards for description guaranteed by norms, which, in turn, highlights the need to broaden the perception of how these guidelines can be contributory in this scenario. The number of resolutions that present approaches related to these two core archival functions represents 10% of the resolutions published by CONARQ, which highlights the need to expand this discussion.
The Need for Rabbinic Nomikoi: A Response to Yair Furstenberg
Authors: Czajkowski Kimberley
Published: December 2023

Yair Furstenberg, in his article “The Rabbinic Movement from Pharisees to Provincial Jurists” (DOI: 10.1163/15700631-bja10070), draws parallels between the rise of the rabbinic movement and jurists in other Eastern provinces of the Roman Empire. This response considers how far we may push the comparison, especially with regard to the stimuli behind the changes in rabbinic activities that Furstenberg posits.
The Triple Helix Model and Working with Loet Leyesdorff
Authors: Lawton Smith Helen
Published: December 2023

This article is a reflection on the enormous debt that I owe Loet for his kindness, generosity and intellectual mentorship. This is over a period of some twenty years. Loet also became part of the Centre for Innovation Management Research (CIMR) at Birkbeck, University of London. In one of our final articles together, Loet drew the different stands of his work together by exploring synergies in scholarship of members of CIMR.
Transfer of Surveillance Technology and End-Use Human Rights Abuses
Authors: Carpanelli Elena
Published: December 2023

This article focuses on the transfer of surveillance technology that is used to commit human rights violations and questions the international responsibility of the technology-exporting State, that is the State where the seller is based and that authorises the transfer. After having clarified that the technology-exporting State cannot be considered the principal wrongdoer for the human rights abuses committed in the receiving State, it investigates whether its international responsibility for end-use human rights abuses could be determined out of complicity or if due diligence may serve the same purpose.
Pre-service Science Teachers’ Perceptions of the Aesthetic Features of Science
Authors: Bae Kyungsuk , Oh Jun-Young , Son Yeon-A
Published: December 2023

This study investigated the perception of aesthetic features within science among 73 pre-service science teachers and its implications for science education. We developed an analytical framework and questionnaire to administer to teachers. The findings revealed notable distinctions in how participants perceived aesthetic aspects, particularly between the ‘nature’ domain and others. Furthermore, some respondents exhibited negative perceptions, largely due to their naive understanding of the nature of science, while others simply acknowledged contradictions within aesthetic features. The study offers several crucial implications, including that pre-service science teachers should be granted more opportunities for hands-on experiences in the field of science; educational interventions aimed at reshaping pre-service teachers’ views on the nature of science are imperative; and there is a need to provide opportunities for pre-service teachers to recognize and grapple with opposing aesthetic features within science. Additionally, explicit education on aesthetics within the context of science is warranted.
Translanguaging, Word and Image, and the Danse Macabre
Authors: Léglu Catherine
Published: December 2023

The late medieval Danse Macabre, a bilingual word-and-image tradition, may be understood through the theoretical lens of translanguaging. This article begins with an analysis of the visual reception of this tradition in a public art installation in Luxembourg City during the coronavirus pandemic, and is followed by the challenges of applying paratranslation to a page of the early printed Danse Macabre (1486). Returning to the earliest translations of the Danse, the article also examines evidence of untranslatability and tensions between three literary languages in the Catalan Dança de la Mort (c. 1490).
A new insular species of Begonia (Begoniaceae) from São Paulo State, Brazil
Authors: MIRANDA MARCELO DIAS
Published: December 2023

Begonia schizostya, a new species of Begonia sect. Astrothrix from São Paulo state, Brazil is described. Begonia schizostyla is morphologically similar to Begonia bullatifolia and Begonia crispula, with which it is compared. The new species grows in Ombrophilous Dense Submontane Forest, over rocks inside the primary forest of São Sebastião Island. Description, comparisons with related species, etymology, taxonomic comments, illustration and localization map of the new species are provided.
From Wonder to Transformation: The Lived Experience of Profound Awe
Authors: Hlava Patty , Elfers John , McGregor Dawn Celeste , Arreguin Sonia , Sharpe Farrah
Published: December 2023

This grounded theory study addressed the question: What model explains the lived experience of profound awe? It emerged out of a recognition that awe continues to be defined as a distinct emotion, and fails to account for the possible range of intensity of affect inherent to awe. Forty interviews were conducted with participants who identified as having had a profound experience of awe. A meditation script was used to induce a high level of memory recall of their experience. Results of the grounded theory analysis yielded three major themes: readiness, overwhelm, and beyond the everyday self. Profound awe was found to be a self-transcending emotion experience that dissolves self/other boundaries of the ego-identity into a small self or expansive self. The varied emotion appraisals ranged in intensity from mild to profound peak experience, with the potential to be transformative.
“This is Slowly Becoming my Interest…”: The Understanding of Leisure and Preferences for Leisure Activities of People Receiving Adult Day Services
Authors: Rommerskirch-Manietta Mike , Manietta Christina , Purwins Daniel , Van Haitsma Kimberly , Abbott Katherine M. , Roes Martina
Published: December 2023

Currently it is unknown what people receiving adult day services (ADS) understand as leisure and the activities they prefer remain unknown. To address these gaps, we investigated the understanding of leisure of people receiving ADS. We conducted semistructured interviews with 15 people receiving ADS in Germany. Interviews were analyzed using reflexive thematic analysis. The sweet bitter symphony emphasizes the sensations that shape participant’s understanding of leisure. Young, wild & free! describes the types of preferred activities. Is this our last tango? refers to the barriers. Anchors aweigh! the [ongoing] voyage describes the process by which leisure is transferred from private domain to the ADS environment. The beginning is the end is the beginning illustrates the paradox of understanding the ADS as offering a form of leisure and the adaptation to engage in nonpreference-based activities. Our findings indicate the importance in offering leisure activities that enable preference-based engagement in the ADS.
Firearms Markets, Marketing, and Society
Authors: Witkowski Terrence H.
Published: December 2023

This special issue consists of three articles that examine, in turn, the advertising portrayals of women in recent issues of Guns & Ammo magazine, the morality of firearms as discussed by the creators and consumers of Brazilian social media, and the appropriation of Native American characters and language by major U.S. gun companies.
Bone implant substitutes from synthetic polymer and reduced graphene oxide: Current perspective
Authors: Senthil Rethinam
Published: December 2023

In the present work, bone implant materials (BIM) were produced, in sheet form which comprises epoxy resin (synthetic polymer) (ER), calcium carbonate (CaCO3), and reduced graphene oxide (R-GO), by open mold method, for the possibility uses in bone tissue engineering. The developed BIM was analyzed for its physico-chemical, mechanical, bioactivity test, antimicrobial study, and biocompatibility. The BIM had excellent mechanical properties such as tensile strength (194.44 + 0.21 MPa), flexural strength (278.76 + 0.41 MPa), and water absorption (02.61 + 0.24%). A pore size distribution study using the HR-SEM has proved the 180 and 255 μm average pore was observed in the BIM structure. The Bioactivity test of BIM was examined after being immersed in a simulated body fluids (SBF) solution. The result of BIM formed an excellent deposition of bone tube apatite crystals. High-resolution scanning electron microscopy (HR-SEM) morphology of the bone tube apatite crystals revealed the diameter size in the range from 100 ± 159 to 210 ± 188 nm. BIM has excellent antimicrobial characteristics against E. coli (8.75 + 0.06 mm) and S. aureus (9.82 + 0.08 mm). The biocompatibility of the study MTT (3-(4, 5-dimethyl) thiazol-2-yl-2, 5-dimethyl tetrazolium bromide) assay using the MG-63 (human osteoblast cell line) has proven to be the 78% viable cell presence in BIM. After receiving the necessary approval, the scaffold with the required strength and biocompatibility could be tested as a bone implant material in large animals.
Identifying Specific Gaps in Knowledge of Aging and Examining Its Relation to Biases Toward Older Adults
Authors: Caskie Grace I. L. , Canell Anastasia E. , Bashian Hannah M.
Published: December 2023

Accurate aging knowledge is key to reducing ageist attitudes that impact older adult well-being. We first investigated how aging knowledge and negative and positive age-bias indirectly expressed via aging knowledge responses were related to an explicitly negative ageism measure. We then identified specific gaps in the aging knowledge of emerging adults and middle-aged adults. More negative ageism correlated with less aging knowledge overall and in psychological and social, but not biological, domains. Negative ageism correlated with negative age-bias, but not positive age-bias, expressed via aging knowledge responses. Knowledge of aging was poorest regarding social and psychological aspects of aging and best regarding biological aging. Middle-aged adults had slightly, but significantly, more accurate aging knowledge and less negative age-bias than emerging adults; positive age-bias did not differ by age-group. These results suggest that effectiveness of anti-ageism educational interventions may be enhanced if focused on improving knowledge of social and psychological aging.
Irreversibility mixed convection Jeffrey fluid flow analysis in a vertical channel with an inclined magnetic field and Soret effects under slip conditions
Authors: Kolla Kaladhar , Mahla Ravi
Published: December 2023

Jeffrey fluid flow is found to have extensive applications in many fields of engineering. There are numerous applications of Jeffrey fluid in polymer industries and industrial fluids such as paints, paper, toothpaste, ketchup, etc. The present work explains the irreversibility of Jeffrey fluid in mixed convection Navier–slip flow through a vertical channel having an inclined magnetic field. The model equations of linear momentum, energy, and concentration are formulated and numerically solved using the spectral quasi-linearization method. The outcomes are depicted graphically and quantitatively discussed for active parameters that appeared in mathematical formulations. Moreover, flow and cross-flow velocity increase with an enhancement in Soret number and magnetic parameter, whereas heat transfer rate decreases with these parameters. Temperature, cross-flow velocity, and heat transfer decrease as the inclination angle increases. Flow velocity, concentration, and mass transfer rise as the inclination angle rises. The results demonstrate that as the magnetic parameter, hall parameter, angle of inclination, and slip condition at the right plate increase, the entropy generation number also increases. Conversely, it decreases as the slip condition at the left plate and Jeffrey fluid parameter increase.
Terbinafine-induced Myositis: A Case Report
Authors: Shariff Atiqulla , Shetty Vaishakhi , Singh Muskan , Kumari Anjani , Sridhar Sathvik Belagodu , Siddalingegowda Srikanth Malavalli
Published: December 2023

We report a case of terbinafine-induced myositis in a 37-year-old Asian male patient treated for Tinea cruris. The patient complained of severe generalized body aches, weakness, fever, fatigue, and passing of concentrated urine after consuming one dose of terbinafine 250 mg tablet, which worsened after the second dose. At the presentation, the patient was afebrile, fatigued, and had difficulty moving. All the laboratory parameters were normal, except N-acetyl-cysteine-(NAC)-activated creatine kinase, which was elevated to 276 U/L. There was a slight elevation in alanine transaminase (ALT) levels (44 U/L) and albumin-to-globulin ratio (1.8). The oral terbinafine was stopped. Patient was prescribed with tablet acetaminophen 650 mg thrice daily for two days and as needed thereafter, to manage myalgia. The patient reported being symptomatically better after six days of terbinafine withdrawal. The Naranjo’s causality assessment scale score was eight, indicating a probable relation between drug exposure (terbinafine use) and adverse drug reaction (myositis). The severity of terbinafine-induced myositis in this patient was moderate (level 3) as categorized by the Modified Hartwig and Siegel scale.
Concomitant Non-V600E BRAF and KRAS Mutations in Colorectal Carcinoma by Next-Generation Sequencing: A Distinct Subtype
Authors: Srivastava Pallavi , Mishra Sridhar , Shukla Saumya , Sharma Pooja , Husain Nuzhat
Published: December 2023

The RAS-RAF-MEK-ERK signaling cascade is the most frequently affected signaling pathway in colorectal cancer. BRAFV600E mutations serve as a drug-treatable hotspot and KRAS mutations as a predictor of susceptibility to anti-epidermal growth factor receptor therapy. Concomitant non-V600E BRAF and KRAS mutations may coexist and are rarely reported in the literature. We report a patient of colorectal carcinoma with inguinal lymph node metastases harboring mutations at the KRAS and BRAF non-V600E mutation codon detected by next-generation sequencing with an emphasis on clinical, pathological, and therapeutic implications of the mutation and review of the literature.
POCUS guided small saphenous vein cannulation: A novel approach for peripheral venous assess in prone position
Authors: Mohanty Chitta Ranjan , Radhakrishnan Rakesh Vadakkethil , Gupta Anju , Barik Amiya Kumar
Published: December 2023

Peripheral intravenous cannulation (PIVC) is a routine procedure in perioperative, and critical care settings and nearly one-third of the patients may have difficult intravenous access (DIVA). PIVC is challenging in a prone position in an intraoperative setting when there is a need for emergency access. Point of care ultrasonography (POCUS) is becoming the standard for assisting DIVA and improving the success rate. The small saphenous vein (SSV) in the posterolateral side of the mid-calf is a consistent vein in the lower extremity that provides an acceptable diameter and optimal depth for POCUS-guided PIVC in the prone position. A successful SSV cannulation was performed with an 18-G peripheral intravenous catheter under POCUS guidance on a 34-year-old male polytrauma patient in the prone position during the intraoperative period scheduled for D2 spine fixation. The SSV can be a credible option for emergency DIVA in the prone position under POCUS guidance.
Single-handed versus multiple-handed general practices: A cross-sectional study of quality outcomes in England
Authors: Holdroyd Ian , Chadwick William , Harvey-Sullivan Adam , Bartholomew Theodore , Massou Efthalia , Tzortziou Brown Victoria , Ford John
Published: December 2023

Objectives

As general practice increasingly moves towards large group practices, there is debate about the relative benefits, safety and sustainability of different care delivery models. This study investigates the performance of single-handed practices compared to practices with multiple doctors in England, UK.

Methods

Practices in England with more than 1000 patients were included. Workforce data and a quality control process classified practices as single-handed or multiple-handed. Outcomes were (i) GP patient survey scores measuring access, continuity, confidence in health professional and overall satisfaction; (ii) reported diabetes and hypertension outcomes; and (iii) emergency department presentation rates and cancer detection (percentage of cancers diagnosed by a 2-week wait). Generalised linear models, controlling for patient and practice characteristics, compared outcomes in single and multiple-handed practices and assessed the effect of GP age in single-handed practices.

Results

Single-handed practices were more commonly found in areas of high deprivation (41% compared to 20% of multiple-handed practices). Single-handed practices had higher patient-reported access, continuity and overall satisfaction but slightly lower diabetes management and cancer detection rates. Emergency department presentations were higher when controlling for patient characteristics in single-handed practices but not when also controlling for practice rurality and size. Increased deprivation was associated with lower performance in seven out of eight outcomes.

Conclusions

We found single-handed practices to be associated with high patient satisfaction while performing slightly less well on selected clinical outcomes. Further research is required to better understand the association between practice size, including increasing multidisciplinary working, on patient experience and outcomes.
What do we know about ‘rape myth’ research and the claim that there is ‘overwhelming evidence’ that juries are prejudiced in rape trials?
Authors: Waiton Stuart
Published: December 2023

This paper examines the research by Fiona Leverick and demonstrates the methodological flaws in much of the ‘rape myth’ and mock jury research. Other ideas about rape myths and the ‘justice gap’ are explored and seen to be questionable. Furthermore, through a detailed examination of the rape myth acceptance scales, which Leverick describes as being ‘scientifically validated’, we trace the ideological and political-ethical nature of these scales and show a clear one-sidedness in how researchers have used them. Most particularly, we find that there is one-sidedness when it comes to the question of victim empathy. One result of this is that mock jury research has indicated that victim empathetic participants are finding individuals guilty of rape, despite the lack of evidence, and almost nothing has been said about the potential miscarriages of justice being demonstrated in these cases. The argument is thus made that rather than there being overwhelming evidence of rape myth prejudices amongst the public, there appears to be a one-sidedness amongst most rape myth researchers that is encouraging a sentiment of victim empathy that could distort the principles of justice regarding defendants being innocent until proven guilty based on a need to prove guilt beyond reasonable doubt. 1
Proposed prediction models for shear strength of fiber reinforced polymer reinforced concrete deep members without stirrups
Authors: Alam Md Shah
Published: December 2023

Arch action in deep reinforced concrete (RC) members has a beneficial effect on shear capacity. The Strut-and-Tie Method (STM) is one of the proposed methods for the design of steel reinforced deep beams (DBs). However, some iterations may require to obtain the optimum solution. This paper investigates the shear capacity of fiber reinforced polymer (FRP)-reinforced DBs using STM and sectional methods of Canadian Standard Association (CSA) and American Concrete Institute (ACI) design provisions. To this end, 106 FRP-reinforced DBs were compiled from the literature. It has been found that current sectional methods do not adequately account for the effects of arch. action on DBs. From this investigation, modifications were proposed in the current sectional methods to calculate the shear capacity of FRP-reinforced DBs. The proposed modifications were found to significantly improve the prediction accuracy. The sectional methods proposed by CSA and ACI were found to be better than the CSA-STM method in predicting the shear capacity of FRP-reinforced DBs.. The mean, standard deviation and coefficient of variation for the proposed CSA sectional method are 1.00, 0.28 and 28.2% and for the proposed ACI sectional method are 1.01, 0.26 and 25.6, respectively. The same for the CSA-STM method are 2.20, 0.76 and 34.4%, respectively. The proposed methods can be used to predict the shear capacity of FRP reinforced deep members.
Seizing the Brain Networks in Lesional Focal Epilepsies
Authors: Zawar Ifrah
Published: December 2023

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Beyond Seizures: The Usefulness of EEG in Septic Patients
Authors: Lapalme-Remis Samuel
Published: December 2023

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