bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenotyping and Association Analysis of Grain Zinc and Iron Content with Seed Yield in Diverse Local Germplasm of Rice
Authors: Tripathy Swapan K.
Published: October 2021

Background: Rice (Oryza sativa L.) feeds more than half of the world population, but it is a poor source of zinc (Zn) and iron (Fe). Therefore, there is a need for Zn and Fe- biofortified rice in the food chain. For this, rice breeding needs to be re-oriented to improve the status of grain Zn and Fe content while increasing the yield potential. Identification of micronutrient-rich donors and their association study with agro-economic traits can pave the way for nutritional and food security. Methods: Zinc and iron content of a set of 92 rice genotypes was estimated in the aliquot of seed extract by using an Inductive Coupled Plasma-Optical Emission Spectrophotometer (ICP-OES) to explore donors and to study the degree of association of these micronutrients with agro-economic traits including grain quality traits and seed yield. Result: The top Fe (≥50 ppm) and Zn dense (≥40 ppm) genotypes identified were P44 mutant selection-1, ORCZ 75-3-1, Basudha, Malliphulajhuli, Tikimahsuri and Nikipankhia. P44 mutant Sel.-1 and ORCZ 75-3-1 had good yield potential (44 q ha-1). Grains/panicles and the number of effective bearing tillers/hill maintained an appreciably strong positive association with seed yield, while plant height had an inverse relationship. Grain Fe content positively correlated with panicle length. On the other hand, Zn is positively associated with tillering ability and grains/panicle. Grain Fe and Zn revealed strong a inter se positive association. Interestingly, grain Fe revealed no association, but grain Zn revealed significant positive relationship with seed yield. This envisaged better scope for genetic enhancement of grain Zn content along with substantial increase in grain Fe without any yield penalty.
FIRST REPORT OF GEOSMITHIA PALLIDA AND G. LANGDONII ASSOCIATED WITH LIPARTHRUM COLCHICUM IN CENTRAL ITALY
Authors: VITALE SALVATORE , LUONGO LAURA , BARZANTI GIAN PAOLO , BINAZZI FRANCESCO , PETRUCCI MARIANGELA , GALLI MASSIMO , PENNACCHIO FABRIZIO , FRANCARDI VALERIA
Published: October 2021

Bark and wood-boring beetles feeding on coniferous and deciduous trees in different forest ecosystems are often associated with various species of fungi. In 2019, widespread attacks of Liparthrum colchicum Semenov (Coleoptera Curculionidae Scolytinae) were observed on Laurus nobilis L. in Tuscany (Italy). Samples of colonized terminal twigs were collected to investigate the presence of phytopathogenic fungi associated with the scolytid. Two different colonies of the Geosmithia genus were identified as Geosmithia pallida and Geosmithia langdonii. To our knowledge this is the first report of G.pallida and G. langdonii associated with L. colchicum on Bay tree, in Italy.
ANALYSIS OF THE TECHNICAL EFFICIENCY OF EUROPEAN SEA BASS FARMS IN TURKEY: A STOCHASTIC FRONTIER PRODUCTION FUNCTION APPROACH
Authors: AYDOÃ„Å¾AN Mehmet , UYSAL Osman
Published: October 2021

This studyââ‚¬â„¢s main objective was to estimate sea bass farmsââ‚¬â„¢ technical efficiency and determine the factors affecting production inefficiency using the stochastic frontier approach. The data were collected using questionnaires from 71 farms in 2017. The total sea bass production cost was calculated 5.35 $ kg-1, income 5.65 $ kg-1, gross profit 0.30 $ kg-1. The proportion of variable costs (84.25%) in total costs was higher than the fixed costs (15.75%). The feed cost (57.56%) was the influential primary variable on the total costs, and the benefit-cost ratio was 1.06. The results indicated that seabass farmsââ‚¬â„¢ technical efficiency varied between 0.67 to 1.00, and the average was 0.82. The efficiency scores meant the farms could achieve the same production amount by reducing inputs by 18%. One per cent increase in resale value, feed amount, and fingerling amount, increase sea bass production by 0.4%, 0.4%, and 0.2%, respectively. Fish loss rates and subsidies were influential on inefficiency. It would be beneficial to minimize risk factors such as fish loss rates and carry out political and educational activities to improve farmsââ‚¬â„¢ infrastructure in breeding and marketing. As a result, policymakers should also include the effective use of production factors in the design of aquaculture subsidy policies.
Multimodality analysis of Jokowi's Social Exchange Theory and Political Marketing to Ma'ruf Amin's infidelity at the 2019 Presidential Election Contestation
Authors: Rustanta Agustinus , Silalahi Evvy
Published: October 2021

In the constellation of the 2019 presidential election, there is something very interesting. Prabowo's camp quickly announced his vice-presidential candidate but Jokowi did not immediately announce his chosen vice-presidential candidate. Even until the last moment, Jokowi let the issue of the vice-presidential candidate rolling in the community. Unexpectedly, Jokowi chose a man who was never included in consideration of public. Jokowi's choice also made several names with the initials M as stated himself that his chosen vice-presidential candidate was M. Surprisingly, he announced that his chosen vice-presidential candidate was Ma'ruf Amin, a senior cleric and Chairman of the MUI (Majelis Ulama Indonesia). The issue of Ma'ruf Amin's selection in this study focuses on social exchange theory from Richard Emerson and the concept of political marketing from Jennifer Lees, especially the MOP (Market Oriented Product) model with a qualitative multimodality approach. Data were analysed using a visual text analysis to dig deeper into Jokowi's non-verbal meaning by deciding to choose Ma'ruf Amin as a vice-presidential candidate. The data were photos of the nomination of the presidential and vice-presidential. The findings of this study are that the election of Ma'ruf Amin is the most appropriate and accurate choice to defeat Prabowo. By choosing Ma'ruf Amin, Jokowi won before competing against Prabowo. Ma'ruf is a symbol, means, and source of Jokowi's victory
THE QUALITY OF HEALTH SERVICE FOR ELDERLY PATIENTS : BETWEEN EXPECTATIONS AND REALITY
Authors: Mustofa Amirul , Rinawati Rinawati
Published: October 2021

The development of the elderly population in the city of Surabaya continues to increase in line with the population growth rate. Naturally, the elderly people experience a biological aging process that has an impact on their health. Therefore, health care for the elderly is an urgent problem to find a solution. This study aims to analyze health services for elderly patients using five dimensions of quality service and to analyze the various expectations of elderly patients on the health services received. The method of research is carried out with a qualitative approach. Data were collected by conducting interviews with several specialist doctors, service officers, elderly patients as service recipients. Interviews were carried out by snowballing in the sense that the researchers conducted rolling interviews from one research subject to another, in order to obtain data that was in accordance with the target focus of the study. The results show, first: of the five dimensions of service, there are four dimensions of service that are in the good evaluation criteria, except for the responsiveness dimension. Second, the services provided are not in accordance with the expectations of service recipients, because health services for elderly patients have not been implemented independently. Various health service facilities have been provided, elderly patients cannot enjoy it comfortably and safely, because they are still mixed with general patients.
Nonalam Disaster Management Policy for The Spread of Covid-19 in The Framework of Regional Autonomy (Central Java Provincial Government Case Study)
Authors: Huda Muhammad Nurul , Purwaningsih Titin , Hammam
Published: October 2021

Coronavirus Disease 2019 (Covid-19) is an infectious disease caused by a type of coronavirus, this virus was first detected in Wuhan, China. Seeing the spread, the transmission of Covid-19 has increased very quickly across countries and continents. The Central Government has declared the non-natural disaster status of the spread of Covid-19 as a National disaster. Seeing the impact of the Covid-19 Pandemic not only causing a health emergency but also having an impact on the social, economic, political, cultural, educational and other fields so that its response requires synergy between the Central Government, Regional Government, the private sector, and the community. This study aims to analyze the effectiveness of non-natural disaster management policies for the spread of Covid-19 by the Central Government and Central Java Provincial Government within the framework of the division of authority through the regional autonomy law. This research method uses descriptive qualitative, using a statute approach and a case approach. The results show that the distribution of authority to the Regional Government to regulate their own household affairs has a positive impact on accelerating the management of non-natural disasters from the spread of Covid-19, on the other hand the negative impact is the potential for overlapping between central and regional policies. However, the potential for overlapping policies can be minimized as long as the Central Government is able to absorb the aspirations of the Regional Government and the Regional Government pays attention to the policies of the Central Government.
The Morphological Classification of the Penile Frenulum in Chinese's People and its Clinical Application Value in the Frenulum Malposition of Circumcision with the Disposable Circumcision Suture Device (DCSD)
Authors: Liu Guang-Ming , Xu Zi-Qiang
Published: October 2021

Background: to conclude the clinical experience of the disposable circumcision suture device (DCSD), to describe the morphological classification of the penile frenulum in Chinese's people, to find a way to solve the malposition of the penile frenulum in the surgery with disposable circumcision suture deviceMethods: From November 2013 to April 2021, there were 2265 consecutive Chinese patients with phimosis 367(16.2%) or redundant prepuce 1898 (83.8%) who underwent circumcision in our hospital. Each patient’s penile frenulum morphological feature was recorded and grouped according to the intraoperative photo documentation. There were four type of frenulum feature: typeⅠ, the middle raphe, a middle line longitudinal from the glan to the scrotal raphe; typeⅡ,the middle double raphe or middle band; type Ⅲ, the diamond or lozenge-shaped raphe; type Ⅳ was marked by the some hyperpigmentation zone. We also reported the convexity frenulum cutting site(CFCS) which could be palpated that a small rounded eminence tissue at the ventral prepuce middle raphe during the prodedure. Other data recorded were operation time, type of anesthesia, intra-operative blood loss, incision healing time, complications, mainly focus on the frenulum distortion, patient satisfaction. RESULTS: According to our morphological classification there were 842 (37.2%) cases in type Ⅰ, 258 (11.4%) cases in type Ⅱ; 107 (4.7%) cases in typeⅢA, 885 (39.1%) cases in type ⅢB and 173 (7.6%) cases in type Ⅳ. Following the classification treatment principle reported in the text no notorious frenulum deviation was observed after the initial 100 cases. Conclusion: The morphological classification of the penile frenulum incombinating with the anatomy marker of CFCS will facilitate accurate identification of the frenulum location, better define its right position, and provide a guide for the DCSD surgery for the individualized patients. The method described in this study could improve the success of the circumcision procedures, lower the related complication and is important to make the device acceptable and popular.
Global Geographical Distribution of Mycobacterium Tuberculosis Complex and the Association Between GHSI and Drug-Resistance
Authors: Tao Bilin , Wu Jizhou , Qiu Beibei , Li Zhongqi , Zhan Mengyao , Wu Zhuchao , Wang Jianming
Published: October 2021

BackgroundMycobacterium tuberculosis complex (MTBC) is the causative agent of tuberculosis (TB). This study aims to map the global distribution of MTBC lineage and to explore the correlation between Global Health Security Index (GHSI) and drug resistance.MethodsWe mapped the global geographic distribution of MTBC lineages using the whole-genome sequencing (WGS) and verified data from the TBProfiler. The hierarchical structure was visualized in different continents and sublineages. We also performed two-dimensional twisted surface and interaction plots to explore the interactions. ResultsLineage 4 was widely distributed globally, while lineage 2 had the highest risk of developing DR-TB. We observed an interaction between GHSI and GDP on the prevalence of multidrug-resistant TB. In countries with ln(GDP per capita) ≥2.35, there was a negative association between GHSI and drug resistance. ConclusionsThere was a significantly different geographic distribution pattern of MTBC lineages in the world. The GHSI was related to the drug resistance of TB and was affected by the social-economic level.
Reexamination of Tsunami Source Models For the 20th Century Earthquakes Off Hokkaido and Tohoku Along the Eastern Margin of the Sea of Japan
Authors: Murotani Satoko , Satake Kenji , Ishibe Takeo , Harada Tomoya
Published: October 2021

Large earthquakes around Japan occur not only in the Pacific Ocean but also in the Sea of Japan, and cause both damage from the earthquake itself and from the ensuing tsunami to the coastal areas. Recently, offshore active fault surveys were conducted in the Sea of Japan by the Integrated Research Project on Seismic and Tsunami Hazards around the Sea of Japan (JSPJ), and their fault models (length, width, strike, dip, and slip angles) have been obtained. We examined the causative faults of M7 or larger earthquakes in the Sea of Japan during the 20th century using seismic and tsunami data. The 1940 off Shakotan Peninsula earthquake (MJMA 7.5) appears to have been caused by the offshore active faults MS01, MS02, ST01, and ST02 as modelled by the JSPJ. The 1993 off the southwest coast of Hokkaido earthquake (MJMA 7.8) likely occurred on the offshore active faults OK03a, OK03b, and OK05, while the 1983 Central Sea of Japan earthquake (MJMA 7.7) probably related to MMS01, MMS04, and MGM01. For these earthquakes, the observed tsunami waveforms were basically reproduced by tsunami numerical simulation from the offshore active faults with the slip amounts obtained by the scaling relation with three stages between seismic moment and source area for inland earthquakes. However, the observed tsunami runup heights along the coast were not reproduced at certain locations, possibly because of the coarse bathymetry data used for the simulation. The 1983 west off Aomori (MJMA 7.1) and the 1964 off Oga Peninsula (MJMA 6.9) earthquakes showed multiple faults near the source area that could be used to reproduce the observed tsunami waveforms; therefore, we could not identify the causative faults. Further analysis using near-field seismic waveforms is required for their identification of their causative faults and their parameters. The scaling relation for inland earthquakes can be used to obtain the slip amounts for offshore active faults in the Sea of Japan and to estimate the coastal tsunami heights and inundation area which can be useful for disaster prevention and mitigation of future earthquakes and tsunamis in the Sea of Japan.
Topical Application of the Anthraquinone Parietin and Blue Light Illumination Induces Delayed Cell Growth and Necrosis in the Deeper Layers of a Subcutaneously Implanted Tumour
Authors: Mugas María Laura , Calvo Gustavo , Marioni Juliana , Céspedes Mariela , Martinez Florencia , Vanzulli Silvia , Sáenz Daniel , Venosa Gabriela Di , Montoya Susana , Casas Adriana
Published: October 2021

Photodynamic therapy (PDT) is an anticancer treatment involving administration of a tumour-localizing photosensitizer, followed by activation by light of a specific wavelength.In previous work, we showed that the natural anthraquinone (AQ) Parietin (PTN), was a promising photosensitizer for photodynamic therapy of leukemic cells in vitro. The present work aimed to analyze the photosensitizing ability of PTN in the mammary carcinoma LM2 cells in vitro and in vivo in a model of subcutaneously implanted tumours.Photodynamic therapy mediated by Parietin (PTN-PDT) (PTN 30 µM, 1 h and 1.78 J/cm2 of blue light) impaired cell growth and migration of LM2 cells in vitro. PTN per se induced a significant decrease in cell migration, and it was even more marked after illumination (migration index was 0.65 for PTN and 0.30 for PTN-PDT), suggesting that both PTN and parietin-mediated PDT would be potential inhibitors of metastasis.Fluorescence microscopy observation indicated cytoplasmatic localization of the AQ and no fluorescence at all was recorded in the nuclei.When PTN (1.96 mg) dissolved in dimethyl sulfoxide was topically applied on the skin of mice subcutaneously implanted with LM2 cells, PTN orange fluorescence was strongly noticed in the stratum corneum and also in the inner layers of the tumour up to approximately 5 mm. After illumination with 12.74 J/cm2 of blue light, one PDT dose at day 1, induced a significant tumour growth delay at day 3, which was not maintained in time. Therefore, we administered a second PTN-PDT boost on day 3. Under these conditions, the delay of tumour growth was 28 % both on days 3 and 4 of the experiment.Histology of tumours revealed massive tumour necrosis up to 4 mm of depth. Intriguingly, a superficial area of viable tumour in the 1 mm superficial area, and a quite conserved intact skin was evidenced. We hypothesize that this may be due to PTN aggregation in contact with the skin and tumour milieu of the most superficial tumour layers, thus avoiding its photochemical properties.On the other hand, normal skin treated with PTN-PDT exhibited slight histological changes. These preliminary findings encourage further studies of natural AQs administered in different vehicles, for topical treatment of cutaneous malignancies.
Ribonuclease-1 treatment after traumatic brain injury preserve the integrity of the neurovascular unit, decreases inflammatory response and delays secondary brain damage in mice
Authors: Krämer Tobias J. , Hübener Per , Pöttker Bruno , Gölz Christina , Neulen Axel , Pantel Tobias , Goetz Hermann , Ritter Katharina , Thal Serge C , Schäfer Michael K.E.
Published: October 2021

Traumatic brain injury (TBI) involves primary mechanical damage and delayed secondary damage caused by vascular dysfunction and neuroinflammation. Intracellular components released into the parenchyma and systemic circulation, termed danger-associated molecular patterns (DAMPs), are major drivers of vascular dysfunction and neuroinflammation. These DAMPs include cell-free RNAs (cfRNAs), which damage the blood–brain barrier (BBB), thereby promoting edema, procoagulatory processes, and infiltration of inflammatory cells. We tested the hypothesis that intraperitoneal injection of Ribonuclease-1 (RNase1, two doses of 20, 60, or 180 µg/kg) at 30 min and 12h after controlled-cortical-impact (CCI) can reduce secondary lesion expansion compared to vehicle treatment 24h and 120h post-CCI. The lowest total dose (40 µg/kg) was most effective at reducing lesion volume (−31% RNase 40µg/kg vs. vehicle), brain water accumulation (−5.5%), and loss of BBB integrity (−21.6%) at 24h post-CCI. RNase1 also reduced perilesional leukocyte recruitment (−53.3%) and microglial activation (−18.3%) at 120h post-CCI, but there was no difference in lesion volume at this time and no functional benefit. Treatment with RNase1 in the early phase following TBI stabilizes the BBB and impedes leukocyte immigration, thereby suppressing neuroinflammation. RNase1-treatment may be a novel approach to delay brain injury to extend the window for treatment opportunities after TBI.
Organic Matter Removal in a Simultaneous Nitrification-Denitrification Process Using Fixed-Film System.
Authors: Gonzalez Perla , Ruiz Ana Aguilar , Varela Andrea Reynosa , Hinojosa Ulises Durán , Zuñiga Marco Garzón , Escalante Edna Meza , Valencia Luis Álvarez , Palacios Denisse Serrano
Published: October 2021

This study focused on evaluating different support media for COD and nitrogen compound removal from an Upflow Anaerobic Sludge Blanket (UASB) reactor fed with swine wastewater. Maximum specific nitrification (MSNA) and denitrification (MSDA) activity tests were performed in two fixed-film systems with (1) polyurethane foam (R1) and (2) polyethylene rings (R2). The results showed that the R2 system performed more efficiently than R1, reaching organic matter removal of 77 ± 8% and nitrogen of 98 ± 4%, attributed to higher specific denitrifying activity recorded (5.3 ± 0.34 g NO3--N/g VTS ∙h). In this sense, MSDA tests indicated that the suspended biomass was responsible for at least 70% of nitrogen removal in the form of ammonium compared with 20% attributed to biomass in the form of biofilm. On the other hand, 40 ± 5% of initial nitrogen could not be quantified in the system effluents, but 10 ± 1% was attributed to loss by volatilization. According to the analyses, the previous information infers the development of simultaneous nitrification-denitrification (SND) routes. Respect to the analyses of microbial diversity and abundance in the biofilm of R2 rings, the presence of the genus Pseudomonas dominated the prokaryotic community of the system in 54.4%.
Up Regulation of GSDMB Is Correlated With Poor Prognosis and Immune Infiltrates in Clear Cell Renal Cell Carcinoma
Authors: Cui Yuanshan , Zhou Zhongbao , Chai Yumeng , Zhang Yong
Published: October 2021

Background: Gasdermin B (GSDMB) is part of the gasdermin (GSDM) family and they use varying means of domain interactions in molecules to adjust their pore-forming and lipid-binding actions. The GSDM family has roles in the regulation of cell differentiation and proliferation, particularly in the process of pyroptosis. Nonetheless, the correlation of GSDMB with immune infiltrates and its prognostic values in Clear Cell Renal Cell Carcinoma (ccRCC) are still undefined. Therefore, we assessed the correlation of GSDMB with immune infiltrates and its prognostic role in ccRCC. Methods: The transcriptional expression profiles of GSDMB in ccRCC tissues in addition to normal tissues were retrieved from the Cancer Genome Atlas (TCGA), and additionally verified in a different independent cohort, which was obtained from the gene expression omnibus (GEO) database. The Human Protein Atlas and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) were accessed to assess the protein expression of GSDMB. To differentiate between ccRCC and surrounding normal tissues, the receiver operating characteristic (ROC) curve was applied. Relationships between GSDMB expression, clinicopathologicical variables, and overall survival (OS) were evaluated with multivariate methods as well as Kaplan-Meier survival curves. Protein-protein interaction (PPI) networks were created with String. Functional enrichment analyses were conducted by utilizing the “ClusterProfiler” package. The tumor immune estimation resource (TIMER) and tumor-immune system interaction database (TISIDB) were utilized to determine the association between the mRNA expression of GSDMB and immune infiltrates. Results: GSDMB expression was significantly more up regulated in ccRCC tissues compared to surrounding normal tissues. An increase in the mRNA expression of GSDMB was related to high pathologic stage and advanced TNM stage. The analysis of the ROC curve indicated that GSDMB had an AUC value of 0.820 to distinguish between ccRCC tissues and adjacent normal controls. Kaplan-Meier survival analysis indicated that ccRCC patients with high-GSDMB had a poorer prognosis compared to those with low-GSDMB (P < 0.001). Correlation analysis showed that the mRNA expression of GSDMB was associated with immune infiltrates and the purity of the tumor. Upregulation of GSDMB is significantly related to immune infiltrates and poor survival in ccRCC. Conclusions: The results of this study indicates that GSDMB could be regarded as a biomarker for the detection of poor prognosis and potential target of immune treatment in ccRCC.
Discriminative and Robust Feature Learning for MIBCI-based Disability Rehabilitation
Authors: Huang Xiuyu , Zhou Nan , Choi KupSze
Published: October 2021

BackgroundIn the past few years, motor imagery brain-computer interface (MIBCI) has become a valuable assisting technology for the disabled. However, how to effectively improve the motor imagery (MI) classification performance by learning discriminative and robust features is still a challenging problem.MethodsIn this study, we propose a novel loss function, called correntropy-based center loss (CCL), as the supervision signal for the training of the convolutional neural network (CNN) model in the MI classification task. With joint supervision of the softmax loss and CCL, we can train a CNN model to acquire deep discriminative features with large inter-class dispersion and slight intra-class variation. Moreover, the CCL can also effectively decrease the negative effect of the noise during the training, which is essential to accurate MI classification.ResultsWe perform extensive experiments on two well-known public MI datasets, called BCI competition IV-2a and IV-2b, to demonstrate the effectiveness of the proposed loss. The result shows that our CNNs (with such joint supervision) achieve 78.65% and 86.10% on IV-2a and IV-2b and outperform other baseline approaches.ConclusionThe proposed CCL helps the learning process of the CNN model to obtain both discriminative and robust deeply learned features for the MI classification task in the BCI rehabilitation application.
The variation of volatile compounds emitted from aromatic orchid (Phalaenopsis bellina) at different timing and flowering stages
Authors: Mus Ahmad Asnawi , Gansau Jualang Azlan , Kumar Vijay Subbiah , Rusdi Nor Azizun
Published: October 2021

Phalaenopsis bellina, is an orchid widely known for their distinctive fragrance. Of late, fragrant orchids are getting more attention from Orchid breeders for their horticultural market value. Although volatile compounds have been identified in several orchid species, the floral scent emission of P. bellina is far from understood. Therefore, this study was carried out to investigate the influence of different timing and floral development stages on the volatile emissions from P. bellina flowers using Solid Phase Micro Extraction (SPME) and Gas Chromatography-Mass Spectrometry (GC-MS). The volatile compound was extracted during morning and afternoon sessions from three different floral developmental stages. The volatile compounds emitted from flowers from two different sessions were trapped with SPME fiber for 30 minutes before directly injected into GC-MS for identification. Results showed that approximately 79 volatile compounds were identified, with the terpenoid presented as the major compound class. P. bellina had the highest number of volatiles during the morning and full bloom (41), with 29.82% monoterpene and 23.33% sesquiterpenes accounted in total. α-farnesene (19.56%) was abundance during morning emission and remains as the highest volatile in afternoon emission (44.08%), even higher when compared to morning emission. However, a decrease in the volatile compound was observed in afternoon emission, in which only 34 volatile compounds detected. Meanwhile, partial bloom developmental stage revealed linalool as the major terpenoid volatile compounds (25.89%), with only 20 volatile compounds recorded. On the other hand, no volatile compounds were recorded and profiled from flower bud stage. The establishment of a floral scent study provides a brief overview of the regulation of fragrance in P. bellina, which can be continued through gene isolation or fragrance-related enzymes study. This information will provide necessary information on orchid floral scent research that useful in boosting horticultural trade of the scented orchids and their function in pollination ecology study
Structural and regional features of the development of Russia’s agri-food exports
Authors: Goryachko M. D. , Leonenko N. S.
Published: October 2021

The recent interest in the topic of agri-food exports is caused by investment activity in agriculture after 2014 and, as a consequence, the positive dynamics of the main indicators of the industry's development. Russia’s food exports has grown more than 15 times since the early 2000s, and the dozens of countries around the world buy this food. At the same time, there are structural and regional features that indicate the limited results achieved in foreign trade, but Russia’s agri-food exports are growing only at the expense of three categories of goods (grain, vegetable oil and fish) with a lower added value than by top-processed food products. It is noted that despite the large number of importing countries, only a few of them purchase significant volumes of Russia’s food. The aim of the study is to quantify the regional differences in the involvement of the territory in the export of food and agricultural raw materials. The assessment showed that most of the Russia’s regions are poorly involved in foreign trade, therefore more than half of all food exports belong to several regions that have a large seaport and produce one of the three main food products. Based on the assessment results, a typology of Russia’s regions is presented according to the criterion of involvement in Russia’s export of agricultural products, taking into account the characteristics of exported products (upper, middle or lower processing). The results obtained make it possible to assess the real export activity of the agroindustrial sector of the regions and the potential for its increase in the future. To calculate the dynamics and regional distribution of Russia’s food exports we used the database of the Federal Customs Service of Russia (HS codes 01-24). In the article, we also calculated the Balassa index and the export diversification index, modified for analyzing the involvement of Russia’s regions in the export of agricultural products.
The state of the Russian grain market
Authors: Agapkin A. M. , Makhotina I. A.
Published: October 2021

Grain production determines the stable functioning of the food market and the economic security of Russia. The authors present an assessment of the results of the analysis of the cultivation and sale of grain crops in the Russian Federation, show the dynamics of the Russian grain market and determine the prospects for its development in comparison with world grain producers. A decrease in the dependence of this market on the negative impact of external factors was revealed. It is noted that the domestic demand for grain crops tends to decrease, while the export remains at a high level. In this regard, the role of grain as a strategic export commodity for the Russian Federation is increasing, which has a significant impact on the economy as a whole and the budget of the Russian Federation in particular. At the same time, the Government of the Russian Federation uses various mechanisms for regulating prices for grain crops, such as curbing grain exports with tariff quotas. The article also presents data on the volume of world grain production over the past ten years, analyzes the structure of production by types of grain crops. Based on the given forecasts of the FAO and the International Grain Council (IGC) regarding the production and consumption of cereals in the world in the next two years, the authors assume an increase in the export potential of Russia, primarily wheat. The study used general logical methods: analysis, synthesis, generalization, induction.
The impact of new global and regional trends on the national economic security of Russia
Authors: Turaeva M. O. , Gorokhova I. V.
Published: October 2021

The article examines how the transforming picture of the world and the changing balance of political forces in the Eurasian space affect Russian economic security. The authors make an attempt to assess this influence, first of all, in the light of changes in the geopolitical situation in the world, when the concept of a polycentric world was put forward in contrast to the economic and political dominance of the West. The sanctions imposed by Western European states and their consequences have given a certain impetus to the development of the Russian economy and its movement towards overcoming dependence on imports. This vector of the national economy, in turn, provided significant support to Russia in the context of the COVID-19 pandemic. Recognizing that at present, estimates of how the Russian economy has overcome the consequences of the coronavirus crisis are only conditionally objective and much depends on the current information policy, the article provides data from major international organizations and agencies on the impact of the pandemic on the economic growth of Russia, developed countries and the EAEU countries. Considering the events on the southern borders of the post-Soviet space that have worsened regional security, the authors determine the position of Russia in its relations with the Central Asian republics, as well as priorities in the development of Eurasian integration to ensure its national security.
Pharmacotherapy for SARS-CoV-2 and Seizures for Drug Repurposing
Presumed on Mechanistic Targets
Authors: Goel Divya , Srivastava Ankit , Aledo-Serrano Ángel , Krishnan Anuja , Vohora Divya
Published: October 2021

Background:

The currently circulating novel SARS-CoV-2 coronavirus disease
(COVID-19) has brought the whole world to a standstill. Recent studies have deciphered the viral
genome structure, epidemiology and are in the process of unveiling multiple mechanisms of pathogenesis.
Apart from atypical pneumonia and lung disease manifestations, this disease has also been
found to be associated with neurological symptoms, which include dizziness, headache, stroke, or
seizures, among others. However, a possible direct or indirect association between SARS-CoV-2
and seizures is still not clear. In any manner, it may be of interest to analyze the drugs being used
for viral infection in the background of epilepsy or vice versa.

Objective:

To identify the most credible drug candidate for COVID-19 in persons with epilepsy or
COVID-19 patients experiencing seizures.

Methods:

A literature search for original and review articles was performed, and further, the Comparative
Toxicogenomics Database was used to unearth the most credible drug candidate.

Results:

Our search based on common mechanistic targets affecting SARS-CoV-2 and seizures revealed
ivermectin, dexamethasone, anakinra, and tocilizumab for protection against both
COVID-19 and seizures. Amongst the antiseizure medications, we found valproic acid as the most
probable pharmacotherapy for COVID-19 patients experiencing seizures.

Conclusion:

These findings would hopefully provide the basis for initiating further studies on the
pathogenesis and drug targeting strategies for this emerging infection accompanied with seizures or
in people with epilepsy.
A Clinical Comparison of Imported or Locally Acquired COVID-19 Suggests Declining Severity after Viral Passages at the Early Stage of the Pandemic in China
Authors: Su Feifei , Yang Shoufeng , Hong Liang , Sun Yao , Qu Yue
Published: October 2021

Objective:

This retrospective, two-center study aimed to provide solid clinical evidence to support the viral attenuation theory after passages of SARS-CoV-2 during the early stages of the pandemic.

Methods:

Clinical characteristics and outcomes of 150 COVID-19 patients hospitalized in Wenzhou, China between January and April 2020 were compared. These patients had similar demographic characteristics. Infections of 77 patients who visited Wuhan within 14 days before symptom onset were categorized as imported cases and that of the remaining 73 patients who had no recent travel history were categorized as locally transmitted cases.

Results:

COVID-19 cases in Wenzhou appeared to be mostly mild at the early stages of the pandemic. There were no differences in clinical manifestations, laboratory testing results, and radiographic presentation between imported and locally transmitted cases in Wenzhou, except that a higher proportion of lymphopenia was found in the imported case group. Assessment of infection severity showed that severe conditions were observed in 10.7% of the patients, with the imported case group having a significantly higher rate (15.6%) than the locally transmitted case group (5.5%, x2 = 4.016, p = 0.045).

Conclusion:

Although, the clinical manifestations of locally acquired infections were indistinguishable from those imported from Wuhan, they were less likely to develop into severe medical conditions, suggesting the possibility of virulence attenuation after viral passages during the early stages of the pandemic.
AÇÕES DE EDUCAÇÃO AMBIENTAL DESENVOLVIDAS EM ESCOLAS DO INTERIOR DA BAHIA
Authors: Oliveira de Assis José , Rempel Claudete , Maciel Mônica Jachetti
Published: October 2021

Educação Ambiental (EA) consiste nos processos em que o indivíduo ou um grupo de pessoas toma consciência de sua realidade global enquanto parte integrante do meio ambiente. O estudo da EA no espaço escolar visa à formação de cidadãos conscientes sobre a preservação do meio ambiente, aptos a tomar decisões individuais e coletivas sobre questões ambientais necessárias para o desenvolvimento de uma sociedade sustentável. O presente trabalho teve como objetivo analisar as ações de EA desenvolvidas em duas escolas do interior da Bahia (BA), para isso foram investigadas as atividades realizadas em algumas disciplinas. Esta é uma pesquisa descritivo-exploratória que foi realizada com professores e alunos do Ensino Fundamental e Médio, de duas escolas do interior de Ipirá-BA, por meio da aplicação de um questionário estruturado. Por meio desta pesquisa, pôde-se verificar que existe deficiência nas escolas em garantir uma formação adequada aos professores para que eles possam desenvolver, em sua prática docente educativa, os conteúdos de maneira integrada e associada, no sentido de promover uma nova tomada de direcionamento e conscientização acerca das questões ambientais. Porém, perceberam-se que algumas ações, ainda que incipientes, são desenvolvidas.
A LEITURA DO ESPAÇO EM POESIAS DE CECÍLIA MEIRELES: UMA ABORDAGEM BACHELARDIANA
Authors: Taiara Kottwitz Jéssica
Published: October 2021

Este trabalho traz algumas reflexões acerca dos estudos realizados sobre a imaginação, o espaço e o devaneio, conceitos alicerçados nos trabalhos do filósofo francês Gaston Bachelard (1988; 1989), que refletem sobre a imersão do leitor nas criações literárias, entre elas, a poesia. A fim de exemplificar tais considerações, apresenta-se uma análise dos poemas “Canção da tarde no campo” e “Narrativa”, presentes na obra Vaga música (1942), de Cecília Meireles. A metodologia utilizada consiste em uma pesquisa bibliográfica e análise de poemas, observando a sua relação com a criação poética e os espaços criados pela nossa imaginação. Ao encontrar os poemas, o leitor depara-se com o universo de Cecília e, ao mesmo tempo, com sua própria identidade, momento em que as palavras constituem a criação do espaço poético, da qual podem emergir inúmeras ressonâncias. Os resultados da pesquisa convergem com a ideia de que é através do poder criador da linguagem que o ser humano é capaz de recriar a si mesmo e a sua realidade, percebendo que o mundo também se apresenta como espaço que pode ser transformado. Tais afirmações evidenciam que a poesia está presente nas sutilezas do cotidiano e que um poeta é capaz de percebê-la, convertendo essa presença em palavras que são capazes de nos encantar.
O MODELO DE GESTÃO EDUCACIONAL DAS ESCOLAS CIDADÃS INTEGRAIS DA PARAÍBA: ANÁLISE DE UM CADERNO FORMATIVO À LUZ DO ISD
Authors: Pereira Borba de Araújo Philipe , Mendes Cavalcanti Leite Filipe , Alves Chagas Liliane , Cavalcanti Calabria Thiago Luís
Published: October 2021

Este artigo apresenta uma análise de um dos cadernos de formação desenvolvido pelo Instituto de Corresponsabilidade pela Educação (ICE), intitulado “Modelo de Gestão: Tecnologia de Gestão Educacional”, que orienta e, de certa forma, condiciona a gestão das escolas pertencentes ao Programa de Educação Integral na Paraíba. A análise teve por objetivo identificar quais são os princípios, conceitos e fundamentos presentes no documento. Buscou, ainda, desvelar como estão representadas, no documento, as tensões entre as esferas pública e privada, a partir de aspectos enunciativos do texto (vozes e modalizações). Esta pesquisa se insere no campo da Linguística Aplicada (LA) e compartilha da natureza indisciplinar e transgressiva desse campo do saber (MOITA LOPES, 2006; PENNYCOOK, 2006). Desenvolvido à luz do Interacionismo Sociodiscursivo (BRONCKART, 1999, 2006, 2012), este trabalho também se embasa nas contribuições de teóricos da educação, como Ball (2014), Laval (2019) e Libâneo (2016). Na análise, considera-se que o documento ilustra um movimento que busca atuar fortemente na redução da esfera de autonomia das escolas.
[ID 57284] EFEITOS DOS RITMOS DE DANÇA NA DOENÇA DE PARKINSON: VIABILIDADE DE UM PROTOCOLO PARA UM ENSAIO CLÍNICO RANDOMIZADO
Authors: Moratelli Jéssica , Hames Alexandre Kettlyn , Swarowsky Alessandra , Lourenço Corrêa Clynton , Boing Leonessa , De Carvalho Souza Vieira Melissa , Coutinho de Azevedo Guimarães Adriana
Published: October 2021

Objetivo: Este estudo objetivou verificar a viabilidade de dois protocolos de dança - ritmo binário e ritmo quaternário nas variáveis UPDRS, equilíbrio, congelamento da marcha e qualidade de vida em indivíduos com doença de Parkinson. Metodologia: Realizou-se um ensaio clínico randomizado, comparando a viabilidade de dois protocolos de dança. Vinte sujeitos, diagnosticados com a doença de Parkinson, participaram do estudo e foram divididos aleatoriamente em dois grupos: grupo de ritmo binário e grupo de ritmo quaternário. A intervenção foi realizada duas vezes por semana, com duração de 45 minutos, durante 12 semanas. As variáveis analisadas foram: UPDRS, equilíbrio (Mini-BESTest), congelamento da marcha (FOG-Q) e qualidade de vida (PDQ-39). Resultados: Ambos os protocolos apresentaram resultados positivos no congelamento da marcha, UPDRS e qualidade de vida, além de mostrarem grande aderência nas intervenções, evidenciando serem importantes para o apoio no tratamento da doença. Conclusão: Este estudo de viabilidade é inovador em indivíduos com a doença de Parkinson, apresentando dois protocolos viáveis, que podem se tornar ferramentas relevantes para o tratamento de sintomas motores e não motores na doença de Parkinson.
[ID 57395] INTERNAÇÕES E MORTES POR CAUSAS EXTERNAS ENTRE OS MENORES DE UM ANO, RECIFE, PERNAMBUCO
Authors: Passos de Oliveira Henry Johnson , Manoel Pereira da Silva Victor , Da Silva Raphael Alves , Pereira da Silva Felicialle , Vieira do Bonfim Cristine
Published: October 2021

Objetivo: Descrever as características clínicas e epidemiológicas dos óbitos infantis por causas externas de residentes no Recife, Pernambuco, no período de 2010 a 2016. Metodologia: Estudo transversal, descritivo, com abordagem quantitativa. A população do estudo foi constituída por 83 óbitos infantis por causa externa de residentes no Recife. Utilizou-se o programa R versão 3.6.3 para análise descritiva dos dados. Além disso, utilizou-se o teste de x² para testar se os dados categóricos associados a uma variável se comportam de modo homogêneo. Resultados: No período de estudo foram registrados 83 óbitos infantis por causa externa em residentes na Cidade do Recife - PE.  Os óbitos apresentaram maiores proporções em indivíduos do sexo masculino (n = 44; 53,0%), da raça/cor preta (n = 54; 65,1%) no período pós-neonatal (n = 65; 78,3%). A maior parte dos óbitos foi em decorrência de acidentes envolvendo a respiração, cuja principal causa básica foi inalação do conteúdo gástrico (n = 47; 56,6%). Conclusão: A análise descritiva das características dos óbitos infantis por causa externa possibilita que ações de políticas públicas e efetivas sejam planejadas segundo a multiplicidade de fatores que determinam o risco de morte por causa externa entre os menores de um ano.
[ID 57466] AVALIAÇÃO DO DESENVOLVIMENTO MOTOR DE CRIANÇAS NASCIDAS PREMATURAS: IMPACTO DE FATORES DE RISCO MATERNOS
Authors: Trubian Fernanda , Nathu Lodi Mayra , Cenci Sangali Caroline , De Moura Rodrigues Laura , Saccani Raquel
Published: October 2021

Objetivo: Avaliar o impacto dos fatores de risco maternos sobre o desenvolvimento motor infantil de bebês nascidos prematuros, de 0 a 12 meses de idade corrigida. Metodologia: Participaram 74 bebês nascidos prematuros, cadastrados no Ambulatório do Centro Clínico da Universidade de Caxias do Sul. Para avaliação do desenvolvimento motor dos bebês foi utilizada a Alberta Infant Motor Scale, além de dois questionários para controle de variáveis referentes a fatores de risco biológicos e ambientais. Foi utilizada estatística descritiva e o teste Chi² de Pearson (p=0,05). Resultados: A categorização de desempenho geral da amostra indicou que 14,9% das crianças foram classificadas com atraso para o desenvolvimento motor e 29,7% com suspeita de atraso. Ao associar o desempenho motor com os fatores de risco maternos, destaca-se que as crianças que receberam aleitamento materno apresentaram melhor desempenho motor (Chi²=3,69; p=0,05), onde apenas 37,1% (n=13) da amostra estava abaixo do esperado. Também foi observada associação significativa entre o grau de escolaridade da mãe do bebê e o desempenho motor (Chi²=5,27; p=0,02). Conclusão: Os achados deste estudo indicam que os fatores maternos podem impactar o desenvolvimento motor de bebês nascidos prematuros. A partir dos resultados encontrados, reforça-se a importância da intervenção, que deve ser iniciada precocemente, a fim de reverter ou minimizar atrasos motores.
[ID 57739] ASPECTOS SOCIODEMOGRÁFICOS E ESPACIAIS DOS CASOS DE TUBERCULOSE DROGARRESISTENTE NO ESTADO DE PERNAMBUCO
Authors: França Silva Karla Naiara , Cavalcanti de Lima Felix Luana Ketlen , Marinho Campos Alves Leite Elaine Cristina , Regadas de Macedo Quinino Louisiana , Araújo de Miranda Lopes Katiuscia , Araújo Silva Maria Beatriz
Published: October 2021

Objetivo: Descrever os aspectos sociodemográficos e a distribuição espacial dos casos de tuberculose drograrresistente (TBDR) no Estado de Pernambuco, Brasil, entre os anos de 2015 e 2018. Metodologia: Trata-se de um estudo epidemiológico descritivo, com utilização de dados secundários do Sistema de Informações de Tratamentos Especiais de Tuberculose. Foram analisadas as variáveis sociodemográficas e o padrão de adoecimento dos pacientes notificados. Para análise espacial foi construído mapas temáticos e gráficos demonstrando o coeficiente de incidência anual dos casos de tuberculose drogarresistente em cada município. Resultados: Foram identificados 299 pacientes, sendo 67,3% do sexo masculino, 80,9% de cor não branca, 25,7% com idade entre 21 e 30 anos, 58,5% com menos de sete anos de estudos e 37,7% desempregados. Quanto ao padrão de adoecimento: 38,5% dos pacientes apresentaram inicialmente resistência a rifampicina, 70,2% foram classificados como casos novos e 29,7% abandonaram o tratamento. Os maiores coeficientes de incidência estiveram concentrados em municípios situados na faixa litorânea do estado. Conclusão: Foi possível observar uma relação entre os aspectos sociodemográficos e a distribuição dos casos da tuberculose drogarresistente, cuja maior concentração foi na região metropolitana do Estado de Pernambuco. Espera-se que este estudo sirva de subsídio para mediar ações de controle e vigilância da doença.
Presentation and Treatment of Aggressive, Triple-Negative Carcinosarcoma of the Breast
Authors: Vizgan Niels , Jokar Tahereh , Enayati Ladan , Salyana Muhammad , Gotlieb Vladimir
Published: October 2021

Breast carcinosarcoma is an aggressive subtype of cancer that accounts
for less than a percent of all breast malignancies. Carcinosarcoma is
difficult to diagnose and treat. In the following, we present a case of
breast carcinosarcoma with the treatment method.