bluuebunny/crossref_metadata_2025 huggingface dataset:
A Multi-functional Design Approach to Deal with New Urban Challenges
Authors: Pereira Guimarães M. , Dessì V.
Published: September 2021

The chapter addresses the urban regeneration of an area starting from multi-step interventions in a small square. These interventions consider a multifaceted point of view which respects local ecological processes while ensuring that transit and other economic and social functions take place. This approach encompasses solutions that respond to city scale needs in terms of stormwater management and the local conditions of thermal comfort and livability at the neighborhood scale. The benefits of urban liveability are now well recognized internationally, and among them increased city attractiveness to avoid abandonment is at the table of several local governments. Municipalities worldwide have pushed for the development of new pedestrian spaces or the regeneration of existing ones to foster liveability through a strategy known as Tactical Urbanism. The paper focuses on the first square in the south part of Milan-Italy to receive such intervention. Beyond Tactical Urbanism, but starting from it, this proposal is a preliminary assessment that aims to evaluate permanent and structural interventions in a square that can also contribute to the environmental resilience of the city. Two different software were used to estimate the environmental benefits of the proposal. The software SWMM (US-EPA) was used to evaluate strategies that guarantee the hydraulic invariance of the intervention area. Second, RayMan Pro was used to assess the contribution of the proposed solution to the microclimate by comparing scenarios in terms of the UTCI index, taking as input local climatic data and data present in the literature.
Product design lifecycle information model (PDLIM)
Authors: Niu Xiaojing , Wang Meili , Qin Shengfeng
Published: September 2021

In response to rapidly changing market and customer needs, product design and development (PDD) is evolving into a human-centred and data-driven design paradigm. The design environment gets more open often involving crowdsourcing and the design process becomes more complex, considering product family design along product whole lifecycle development, and needing more data support. Therefore, it is critical to effectively capture, share, and manage design-related information in such a complex design environment. From this perspective, it is a prerequisite to have a proper product design lifecycle information model (PDLIM) to guide information gathering, sharing and management. To the best of our knowledge, currently, there lacks such a PDLIM to support effective PDD, though digital twin (DT) technology shows a great potential of supporting product lifecycle information collection and management. In this paper, the overall structure of the proposed PDLIM is firstly developed to frame in all main product lifecycle stages and the corresponding key phases for structurally capturing and storing necessary data along a product lifecycle. Secondly, key design information items against the main product lifecycle stages and their corresponding key phases are explored from literature reviews and case study analyses. Thirdly, the necessity of the identified information items in the PDLIM is qualitatively evaluated by two case studies. Finally, the PDLIM is further evaluated by applying formal object-role modelling (ORM) to demonstrate how design information items are used and interacted in exemplary design interaction scenarios, and to approve that it can be formally described and managed as an information model. The evaluation results show that the PDLIM is feasible to be adapted in a crowdsourcing-combined PDD process for supporting design management, reviewing, quality control, and next round product redesign and improvement.
Inter-observer agreement using the LI-RADS version 2018 CT treatment response algorithm in patients with hepatocellular carcinoma treated with conventional transarterial chemoembolization
Authors: Bartnik Krzysztof , Podgórska Joanna , Rosiak Grzegorz , Korzeniowski Krzysztof , Rowiński Olgierd
Published: September 2021

Aim

To determine inter-reader agreement in categorization of imaging features using the Liver Imaging Reporting and Data System (LI-RADS) treatment response (LR-TR) algorithm in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE).

Methods

Two radiologists used the LR-TR algorithm to assess 112 computed tomography (CT) examinations of 102 patients treated with cTACE. The inter-observer agreement in categorization of LR-TR features was assessed using kappa (κ) statistics.

Results

There was substantial inter-observer agreement between the two reviewers using the LR-TR algorithm (κ = 0.70; 95% CI 0.58–0.81). The two reviewers categorized tumors as non-viable in 37 (33.0%) and 39 (34.8%) of 112 examinations, viable in 58 (51.8%) and 62 (55.4%) examinations, and equivocal in 18 (16.1%) and 11 (9.8%) examinations, respectively. There was almost perfect inter-observer agreement for the LR-TR non-viable category (κ = 0.80; 95% CI 0.68–0.92), substantial agreement for the viable category (κ = 0.78 95% CI 0.67–0.90), and fair agreement for the equivocal category (κ = 0.25; 95% CI 0.02–0.49).

Conclusion

The LR-TR algorithm conveys high degrees of inter-observer agreement for the assessment of CT imaging features in the viable and non-viable categories. Further refinement of indeterminate features may be necessary to improve the correct categorization of equivocal lesions.

Graphic abstract
Akut symptomatische Anfälle vs. beginnende Epilepsie nach Schlaganfall bei Erwachsenen und Kindern
Authors: Serles Wolfgang
Published: September 2021

Mehr als ein Drittel der neu diagnostizierten Epilepsien bei Patienten über 60 Jahren haben einen abgelaufenen Schlaganfall als Ursache. Bei epileptischen Anfällen nach Schlaganfall müssen akut symptomatische Anfälle innerhalb 1 Woche nach Schlaganfall von unprovozierten epileptischen Anfällen ab 1 Woche nach Schlaganfall unterschieden werden. Erstere haben ein niedriges Rezidivrisiko, Zweitere hingegen führen in 70 % zu einem neuerlichen Anfall. Gemäß der Internationalen Liga gegen Epilepsie (ILAE) erfüllt letztere Konstellation bereits die Kriterien einer beginnenden Epilepsie, wofür nach früheren Definitionen zumindest 2 unprovozierte Anfälle notwendig waren. Akut symptomatische Anfälle stellen allerdings sowohl im Kindesalter als auch beim Erwachsenen einen Risikofaktor für die Entwicklung einer Epilepsie dar. Weitere Risikofaktoren sind die Größe des Infarktes und eine Lokalisation im Bereich der Hirnrinde. Die Studienlage zeigt weder ausreichende Evidenz für eine prophylaktische Gabe der Anfallsmedikation nach Schlaganfall noch für eine Therapie nach akut symptomatischem Anfall, obwohl dies häufig klinische Praxis ist. Daher sollte die medikamentöse Therapie nach der Akutphase des Schlaganfalls beendet werden. Bei Schlaganfallpatienten nach einem unprovozierten Anfall beim Erwachsenen wird eine lebenslange Therapie empfohlen. In der Regel stellt sich durch die Gabe eines Medikamentes ein zufriedenstellender Therapieerfolg ein. Bevorzugt werden sollten neuere Anfallsmedikamente, die besser verträglich sind und ein geringeres Interaktionspotenzial im Rahmen der Polypharmazie bei älteren Patienten haben.
The Weirdness Theorem and the Origin of Quantum Paradoxes
Authors: Benavoli Alessio , Facchini Alessandro , Zaffalon Marco
Published: September 2021

We argue that there is a simple, unique, reason for all quantum paradoxes, and that such a reason is not uniquely related to quantum theory. It is rather a mathematical question that arises at the intersection of logic, probability, and computation. We give our ‘weirdness theorem’ that characterises the conditions under which the weirdness will show up. It shows that whenever logic has bounds due to the algorithmic nature of its tasks, then weirdness arises in the special form of negative probabilities or non-classical evaluation functionals. Weirdness is not logical inconsistency, however. It is only the expression of the clash between an unbounded and a bounded view of computation in logic. We discuss the implication of these results for quantum mechanics, arguing in particular that its interpretation should ultimately be computational rather than exclusively physical. We develop in addition a probabilistic theory in the real numbers that exhibits the phenomenon of entanglement, thus concretely showing that the latter is not specific to quantum mechanics.
Longitudinal Analysis of Inflammatory Response to SARS-CoV-2 in the Upper Respiratory Tract Reveals an Association with Viral Load, Independent of Symptoms
Authors: Vu Diem-Lan , Martinez-Murillo Paola , Pigny Fiona , Vono Maria , Meyer Benjamin , Eberhardt Christiane S. , Lemeille Sylvain , Von Dach Elodie , Blanchard-Rohner Géraldine , Eckerle Isabella , Huttner Angela , Siegrist Claire-Anne , Kaiser Laurent , Didierlaurent Arnaud M.
Published: September 2021

Background

SARS-CoV-2 infection leads to high viral loads in the upper respiratory tract that may be determinant in virus dissemination. The extent of intranasal antiviral response in relation to symptoms is unknown. Understanding how local innate responses control virus is key in the development of therapeutic approaches.

Methods

SARS-CoV-2-infected patients were enrolled in an observational study conducted at the Geneva University Hospitals, Switzerland, investigating virological and immunological characteristics. Nasal wash and serum specimens from a subset of patients were collected to measure viral load, IgA specific for the S1 domain of the spike protein, and a cytokine panel at different time points after infection; cytokine levels were analyzed in relation to symptoms.

Results

Samples from 13 SARS-CoV-2-infected patients and six controls were analyzed. We found an increase in CXCL10 and IL-6, whose levels remained elevated for up to 3 weeks after symptom onset. SARS-CoV-2 infection also induced CCL2 and GM-CSF, suggesting local recruitment and activation of myeloid cells. Local cytokine levels correlated with viral load but not with serum cytokine levels, nor with specific symptoms, including anosmia. Some patients had S1-specific IgA in the nasal cavity while almost none had IgG.

Conclusion

The nasal epithelium is an active site of cytokine response against SARS-CoV-2 that can last more than 2 weeks; in this mild COVID-19 cohort, anosmia was not associated with increases in any locally produced cytokines.
Inferring pulmonary exposure based on clinical PK data: accuracy and precision of model-based deconvolution methods
Authors: Himstedt Anneke , Borghardt Jens Markus , Wicha Sebastian Georg
Published: September 2021

Determining and understanding the target-site exposure in clinical studies remains challenging. This is especially true for oral drug inhalation for local treatment, where the target-site is identical to the site of drug absorption, i.e., the lungs. Modeling and simulation based on clinical pharmacokinetic (PK) data may be a valid approach to infer the pulmonary fate of orally inhaled drugs, even without local measurements. In this work, a simulation-estimation study was systematically applied to investigate five published model structures for pulmonary drug absorption. First, these models were compared for structural identifiability and how choosing an inadequate model impacts the inference on pulmonary exposure. Second, in the context of the population approach both sequential and simultaneous parameter estimation methods after intravenous administration and oral inhalation were evaluated with typically applied models. With an adequate model structure and a well-characterized systemic PK after intravenous dosing, the error in inferring pulmonary exposure and retention times was less than twofold in the majority of evaluations. Whether a sequential or simultaneous parameter estimation was applied did not affect the inferred pulmonary PK to a relevant degree. One scenario in the population PK analysis demonstrated biased pulmonary exposure metrics caused by inadequate estimation of systemic PK parameters. Overall, it was demonstrated that empirical modeling of intravenous and inhalation PK datasets provided robust estimates regarding accuracy and bias for the pulmonary exposure and pulmonary retention, even in presence of the high variability after drug inhalation.
Work, motherhood and women’s affective well-being
Authors: Keldenich Carina
Published: September 2021

This paper analyzes how motherhood and labor market status interact in their relationship to women’s affective well-being using Day Reconstruction Method data from the United Kingdom Time Use Survey 2014–2015. The dataset contains information on how much time respondents spent on their various daily activities as well as how much they enjoyed each episode. This information is aggregated into a measure of an individual’s affective well-being on a given day by calculating the mean of the reported enjoyments weighted by the duration of the respective episode. Results indicate a positive and significant correlation between motherhood and affective well-being. However, this relationship decreases in magnitude and even becomes insignificant in some specifications when controlling for labor market status. This could indicate that an increase in the likelihood of being in a labor market status associated with higher affective well-being mediates the positive relationship between motherhood and affective well-being. Women working part-time, self-employed women, homemakers and women on maternity leave are shown to have higher affective well-being than full-time employees. Furthermore, the time spent on and enjoyment experienced in employment related activities appears to be a key driver of many results in this study. Contrasting results in specifications using a measure of life satisfaction highlight the importance of considering affective as well as cognitive well-being.
Analysis of Damage and Failure in Anisotropic Ductile Metals Based on Biaxial Experiments with the H-Specimen
Authors: Brünig M. , Koirala S. , Gerke S.
Published: September 2021

Background

Dependence of strength and failure behavior of anisotropic ductile metals on loading direction and on stress state has been indicated by many experiments. To realistically predict safety and lifetime of structures these effects must be taken into account in material models and numerical analysis.

Objective

The influence of stress state and loading direction on damage and failure behavior of the anisotropic aluminum alloy EN AW-2017A is investigated.

Methods

New biaxial experiments and numerical simulations have been performed with the H-specimen under different load ratios. Digital image correlation shows evolution of strain fields and scanning electron microscopy is used to visualize failure modes on fracture surfaces. Corresponding numerical studies predict stress states to explain damage and fracture processes on the micro-scale.

Results

The stress state, the load ratio and the loading direction with respect to the principal axes of anisotropy affect the width and orientation of localized strain fields and the formation of damage mechanisms and fracture modes at the micro-level.

Conclusions

The enhanced experimental program with biaxial tests considering different loading directions and load ratios is suggested for characterization of anisotropic metals.
Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers
Authors: Sible Isabel J. , Nation Daniel A. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: September 2021

Blood pressure variability is an emerging risk factor for dementia but relationships with markers of neurodegeneration and Alzheimer’s disease risk are understudied. We investigated blood pressure variability over one year and follow-up medial temporal brain volume change in apolipoprotein ϵ4 carriers and non-carriers, and in those with and without Alzheimer’s disease biomarker abnormality. 1051 Alzheimer’s Disease Neuroimaging Initiative participants without history of dementia or stroke underwent 3–4 blood pressure measurements over 12 months and ≥ 1 MRI thereafter. A subset (n = 252) underwent lumbar puncture to determine Alzheimer’s disease cerebral spinal fluid amyloid-beta and phosphorylated tau biomarker abnormality. Blood pressure variability over 12 months was calculated as variability independent of mean. Longitudinal hippocampal and entorhinal cortex volume data were extracted from serial brain MRI scans obtained after the final blood pressure measurement. Apolipoprotein ϵ4 carrier status was defined as at least one ϵ4 allele. Bayesian growth modelling revealed a significant interaction of blood pressure variability by ϵ4 by time on hippocampal (ß: -2.61 [95% credible interval -3.02, -2.12]) and entorhinal cortex (ß: -1.47 [95% credible interval -1.71, -1.17]) volume decline. A similar pattern emerged in subsets with Alzheimer’s disease pathophysiology (i.e., abnormal levels of both amyloid-beta and phosphorylated tau). Findings suggest that elevated blood pressure variability is related to medial temporal volume loss specifically in ϵ4 carriers, and in those with Alzheimer’s disease biomarker abnormality. Findings could implicate blood pressure variability in medial temporal neurodegeneration observed in older ϵ4 carriers and those with prodromal Alzheimer’s disease.
Current Understanding of Microstructure and Properties of Micro-Alloyed Low Carbon Steels Strengthened by Interphase Precipitation of Nano-Sized Alloy Carbides: A Review
Authors: Zhang Y.-J. , Chandiran E. , Dong H.-K. , Kamikawa N. , Miyamoto G. , Furuhara T.
Published: September 2021

The current understanding of the microstructural features and mechanical properties of micro-alloyed low carbon steels strengthened by interphase precipitation of nano-sized alloy carbides are critically reviewed in this paper. The experimental results obtained via advanced quantitative characterization have revealed that interphase precipitation is promoted at the ferrite/austenite interface with a relatively lower degree of coherency caused by the deviation from the exact Kurdjumov–Sachs orientation relationship. Its dispersion becomes refined by enlarging the driving force for its precipitation, as adjusted by changing the transformation condition and chemical composition. The occurrence of interphase precipitation can significantly increase the strength of steels due to its large precipitation strengthening, and maintain good ductility as a result of enhanced work-hardening and dynamic recovery in different stages of tensile deformation. Finally, the application of interphase precipitation to ferrite/martensite dual-phase steels, together with our outlook on the challenging points in future research, are briefly explained.
Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide
Authors: Zhou Qiuping , Lin Lanfen , Li Haiyan , Wang Huifang , Jiang Shuqi , Huang Peixian , Lin Qiongyu , Chen Xuan , Deng Yiyu
Published: September 2021

Microglia activation and associated inflammation are implicated in the periventricular white matter damage (PWMD) in septic postnatal rats. This study investigated whether melatonin would mitigate inflammation and alleviate the axonal hypomyelination in the corpus callosum in septic postnatal rats. We further explored if this might be related to the modulation of microglial polarization from M1 phenotype to M2 through the JAK2/STAT3/telomerase pathway. We reported here that indeed melatonin not only can it reduce the neurobehavioral disturbances in LPS-injected rats, but it can also dampen microglia-mediated inflammation. Thus, in LPS + melatonin group, the expression of proinflammatory mediators in M1 phenotype microglia was downregulated. As opposed to this, M2 microglia were increased which was accompanied by upregulated expression of anti-inflammatory mediators along with telomerase reverse transcriptase or melatonin receptor 1(MT1). In parallel to this was decreased NG2 expression but increased expression of myelin and neurofilament proteins. Melatonin can improve hypomyelination which was confirmed by electron microscopy. In vitro in primary microglia stimulated by LPS, melatonin decreased the expression of proinflammatory mediators significantly; but it increased the expression of anti-inflammatory mediators. Additionally, the expression levels of p-JAK2 and p-STAT3 were significantly elevated in microglia after melatonin treatment. Remarkably, the effect of melatonin on LPS-treated microglia was blocked by melatonin receptor, JAK2, STAT3 and telomerase reverse transcriptase inhibitors, respectively. Taken together, it is concluded that melatonin can attenuate PWMD through shifting M1 microglia towards M2 via MT1/JAK2/STAT3/telomerase pathway. The results suggest a new therapeutic strategy whereby melatonin may be adopted to convert microglial polarization from M1 to M2 phenotype that would ultimately contribute to the attenuation of PWMD.
Socio-emotional strengths against psychopathology and suicidal ideation in fear of COVID-19
Authors: Soto-Sanz Victoria , Falcó Raquel , Marzo Juan C. , Piqueras José A. ,   PSICO-RECURSOS COVID-19 study group, Lopez-Nuñez Alfonso , Martínez-González Agustín E. , Mateu Ornela , Moreno-Amador Beatriz , Pineda David , Rivera-Riquelme Maria , Rodríguez-Jiménez Tíscar , Vidal-Arenas Verónica
Published: September 2021

Coronavirus disease (COVID-19) has caused a global health crisis. It also leads to different types of psychosocial problems in society as a result of preventive health measures and the disease itself. Among others, psychopathological symptoms and suicide behaviors have increased. The PsicorecurSOS COVID-19 online protocol was designed. At baseline, 1020 Spanish adults were assessed, during confinement, for sociodemographics, fear of COVID-19, anxious-depressive symptoms, covitality, and suicidal ideation. Reliability, descriptive, and frequency analyses were carried out, and the computer tool SPSS PROCESS was used to carry out a conditional process analysis (model 59). A total of 595 participants were included (58.30% response rate from baseline; mean age = 37.18 [SD = 13.30]; 72.44% female). Regarding suicidal ideation, 12% responded differently to “never,” 19.3% exceeded the cutoff point on the anxiety scale, and 24% on the depression scale. Moderate mediation analysis explained 27% of the variance in suicidal ideation. In addition, the indirect effect of moderate mediation was significant (b = −.004, SE = .002 with the presence of covitality; and b = .01, SE = .003 absence of covitality). Sex and age did not influence the overall outcome of the model. The data from this study can serve as a starting point for generating social and health treatment initiatives based on self-examination of anxiety-depressive symptoms and increasing socio-emotional skills in order to prevent and alleviate the psychosocial effects of the pandemic.
Soziale Eingebundenheit von Lehramtsstudierenden: Die Rolle impliziter Theorien bei der Veränderung des Erlebens sozialer Eingebundenheit von Erstsemestern
Authors: Marksteiner Tamara , Hettler Ingo S.
Published: September 2021

Implizite Theorien, i.e. subjektive Überzeugungen, über die Veränderbarkeit von Eigenschaften spielen im Unterrichtsgeschehen eine entscheidende Rolle, da sie Motivation und Lernerfolg sowie Wohlbefinden von Schüler:innen beeinflussen. Bisherige Forschung hat insbesondere implizite Theorien über die Veränderbarkeit von Intelligenz und Fähigkeiten in den Blick genommen. Wenig Beachtung fanden bislang implizite Theorien über emotionales Erleben wie Gefühle sozialer Eingebundenheit.

Die vorliegende Studie untersucht erstmals implizite Theorien über soziale Eingebundenheit bei Lehramtsstudierenden. In zahlreichen Studien konnte bereits die Bedeutung von Gefühlen sozialer Eingebundenheit von Studierenden für deren akademische Leistung, Motivation und Wohlbefinden nachgewiesen werden. Der Untersuchungsbedarf im Lehramtsstudium kann insbesondere vor dem Hintergrund der mit dem Lehramtsstudium verbundenen spezifischen Herausforderungen begründet werden.

Ausgehend von bisherigen Befunden wurde angenommen, dass das soziale Eingebundenheitserleben durch die subjektive Überzeugung, dass man selbst beeinflussen kann, wie sehr man akzeptiert und wertgeschätzt wird, gesteigert wird. In einem längsschnittlich angelegten Design wurdenN = 68 Lehramtsstudierende während ihres ersten Studienjahrs befragt. Zu vier Messzeitpunkten machten die Proband:innen Angaben zu ihren impliziten Theorien sozialer Eingebundenheit sowie ihrem Eingebundenheitserleben. Entgegen der Annahmen deuten die Befunde manifester autoregressiver Modellanalysen an, dass das Eingebundenheitserleben die impliziten Überzeugungen über soziale Eingebundenheit beeinflussen – wobei die Richtung des Einflusses situationsabhängig ist. Die Befunde werden im Hinblick auf theoretische und praktische Implikationen diskutiert.
Performing Early Christian Literature
Authors: Iverson Kelly
Published: September 2021

Scholars of early Christian literature acknowledge that oral traditions lie behind the New Testament gospels. While the concept of orality is widely accepted, it has not resulted in a corresponding effort to understand the reception of the gospels within their oral milieu. In this book, Kelly Iverson reconsiders the experiential context in which early Christian literature was received and interpreted. He argues that reading and performance are distinguishable media events, and, significantly, that they produce distinctive interpretive experiences for readers and audiences alike. Iverson marshals an array of methodological perspectives demonstrating how performance generates a unique experiential context that shapes and informs the interpretive process. Iverson's study explores the dynamic oral environment in which ancient audiences experienced the gospel stories. He shows why an understanding of oral performance has important implications for the study of the NT, as well as for several issues that are largely unquestioned by biblical scholars.
The Causal Structure of Natural Selection
Authors: Pence Charles H.
Published: September 2021

Recent arguments concerning the nature of causation in evolutionary theory, now often known as the debate between the 'causalist' and 'statisticalist' positions, have involved answers to a variety of independent questions – definitions of key evolutionary concepts like natural selection, fitness, and genetic drift; causation in multi-level systems; or the nature of evolutionary explanations, among others. This Element offers a way to disentangle one set of these questions surrounding the causal structure of natural selection. Doing so allows us to clearly reconstruct the approach that some of these major competing interpretations of evolutionary theory have to this causal structure, highlighting particular features of philosophical interest within each. Further, those features concern problems not exclusive to the philosophy of biology. Connections between them and, in two case studies, contemporary metaphysics and philosophy of physics demonstrate the potential value of broader collaboration in the understanding of evolution.
“To Interfere on Their Behalf”: Sovereignty, Networks, and Capital in the Dominican Republic
Authors: Glotzer Paige
Published: September 2021

This article uses a lawsuit between British engineers and Dominican merchants over a sugar estate mortgage to examine how transnational capital networks functioned at the local level during a moment of transition in the late nineteenth-century global economy. When Dominican courts ruled against the engineers, the firm unsuccessfully sought diplomatic intervention, raising questions on the one hand about the incremental construction of Dominican sovereignty and on the other about the links between diplomatic and business networks on the ground. It is situated within calls for new approaches to the history of the Dominican Republic that utilize international archives and focus on corporate bodies, both in local and Pan-Caribbean contexts.
Barriers and opportunities for refugee mental health services: clinician recommendations from Jordan
Authors: Al-Soleiti Majd , Abu Adi Mahmoud , Nashwan Ayat , Rafla-Yuan Eric
Published: September 2021

Background

Jordan has received more than three million refugees from bordering countries during times of conflict, including over 600 000 Syrian refugees between 2011 and 2021. Amidst this humanitarian crisis, a new mental health system for Syrian refugees has developed in Jordan, with most clinical services administered through non-governmental organizations. Prior studies have identified increased risk of psychiatric disorders in refugee populations and significant barriers for Syrian refugees seeking mental health treatment, but few have reviewed the organization or ability of local systems to meet the needs of this refugee population.

Methods

Qualitative interviews of mental health professionals working with refugees in Jordan were conducted and thematically analyzed to assess efficacy and organizational dynamics.

Results

Interviewees described barriers to care inherent in many refugee settings, including financial limitations, shortages of mental health professionals, disparate geographic accessibility, stigma, and limited or absent screening protocols. Additional barriers not previously described in Jordan were identified, including clinician burnout, organizational metrics restricting services, insufficient visibility of services, and security restrictions. Advantages of the Jordanian system were also identified, including a receptive sociopolitical response fostering coordination and collaboration, open-door policies for accessing care, the presence of community and grassroots approaches, and improvements to health care infrastructure benefiting the local populace.

Conclusions

These findings highlight opportunities and pitfalls for program development in Jordan and other middle- and low-income countries. Leveraging clinician input can promote health system efficacy and improve mental health outcomes for refugee patients.
When Does She Rebel? How Gender Affects Deviating Legislative Behaviour
Authors: Dingler Sarah C. , Ramstetter Lena
Published: September 2021

It is common wisdom that the increase in the number of women in parliament brought along a new diversity of perspectives presented in legislatures. So far, however, we know little about the implications of women's presence on party cohesion. Moving towards a more complete understanding of how women affect political processes, this article addresses the question, does gender affect vote defection from party lines, and if so, under what circumstances? We argue that the actual and perceived risk associated with vote defection in roll-call votes is gendered and that this is constraining the leeway of women to rebel. Analysing roll-call vote data of the German Bundestag (1953–2013) provided by Bergmann et al. (2018), we show that gender exerts a consistent effect only if electoral safety and policy content are considered: it is in feminine policy areas and at high levels of electoral security that women are more likely than men to rebel. This finding implies that taking different incentive structures into account is key if we want to understand gendered legislative behaviour.
Purposiveness, Intelligibility and Kant's Scepticism: Reconsidering Ng's Account of Hegel's Response to Kant
Authors: Koch Karen
Published: September 2021

Hegel's integration of the concept of Life in the Logic has long been disputed and rejected by many scholars. The most common objection was that it seemed counterintuitive to integrate an empirical phenomenon such as Life into a Logic that, in fact, ought to present an immanent development of pure concepts. Hegel was often accused of bringing empirical considerations into his Logic in order to develop his logical account of Life. Consequently, there has been a great discussion about the question as to whether a Logic is an appropriate place for this concept—a discussion that did not occur with respect to other categories in Hegel's Logic. Now, in contemporary literature on Hegel, there is a surge of genuine interest in Hegel's logical account of Life, accompanied by the insight that the concept of Life plays an important and indispensable role in Hegel's philosophy. However, what this role is precisely is a controversial issue.
The legacy of Admiral von Tirpitz: a geopolitical understanding of China's naval buildup through sea-denial strategies
Authors: Pizzolo Paolo
Published: September 2021

As manifest challenger of the United States (US)-led international order, the People's Republic of China (PRC) has inaugurated a revisionist strategy that encompasses a multifaceted spectrum of initiatives, including an ambitious naval military build-up. History has shown that revisionist and challenging powers tend to defy the established order through arm races. US Admiral Mahan and German Admiral Tirpitz theorized two different approaches to naval strategy, the former focusing on global maritime hegemony and the latter on regional counterbalance based on risk theory. This article attempts at explaining the puzzle of China's naval buildup through the lenses of geopolitics, adding a geopolitical dimension to the current debate. It suggests that the PRC's naval military development does not follow a Mahanian global maritime strategy aimed at challenging the US primacy worldwide, but rather a Tirpitzian regional approach focused on counterbalancing the US presence within the scope of China's sea power projection, that is, the Pacific region. To substantiate this hypothesis, the study compares diachronically contemporary Chinese naval arm race with Wilhelmine Germany's High Seas Fleet. The findings underscore that, in maritime terms, China's revisionism vis-à-vis the US somewhat resembles that of Imperial Germany vis-à-vis Imperial Britain, both aiming at regional counterbalance and anti-access and area-denial (A2/AD) tactics rather than global maritime counterhegemony. Although Chinese sea power is still far from posing a serious threat to that of the US and its allies, an unrestrained continuation of Beijing's naval buildup could encourage arms races and direct confrontation due to regional security dilemmas.
Steady circular hydraulic jump on a rotating disk
Authors: Ipatova Anna , Smirnov K.V. , Mogilevskiy E.I.
Published: September 2021

The paper deals with the steady axially symmetric flow of a viscous liquid layer over a rotating disk. The liquid is fed near the axis of rotation and spreads due to inertia and the centrifugal force. The viscous shallow-water approach gives a system of ordinary differential equations governing the flow. We consider inertia, gravity, centrifugal and Coriolis forces and estimate the effect of surface tension. We found four qualitatively different flow regimes. Transition through these regimes shows the continuous evolution of the flow structure from a hydraulic jump on a static disk to a monotonic thickness decrease on a fast rotating one. We show that, in the absence of surface tension, the intensity of the jump gradually vanishes at a finite distance from the axis of rotation while the angular velocity increases. The surface tension decreases the jump radius and destroys the steady solution for a certain range of parameters.
The most robust representations of flow trajectories are Lagrangian coherent structures
Authors: MacMillan Theodore , Richter David H.
Published: September 2021

What is the most robust way to communicate flow trajectories? To answer this question, we employ two neural networks to respectively deconstruct (the encoder) and reconstruct (the decoder) trajectories, where information is passed between the two networks through a low-dimensional latent space in a set-up known as an autoencoder. To ensure that their communications are robust, we add noise to the coded information passed through this latent space. In the low-noise limit the latent space structures are non-spatial in nature, resembling modes of a principle component analysis (PCA). However, as the signal-to-noise ratio is decreased, we uncover Lagrangian coherent structures (LCS) as the most compact representations which still allow the decoder to accurately reconstruct trajectories. This relationship offers increased interpretability to both PCA and LCS analysis, and helps to bridge the gap between two methods of flow analysis.
Asymptotic behaviour of positive solutions of semilinear elliptic problems with increasing powers
Authors: Boccardo Lucio , Maia Liliane , Pellacci Benedetta
Published: September 2021

We prove existence results of two solutions of the problem
\[ \begin{cases} L(u)+u^{m-1}=\lambda u^{p-1} & \text{in}\ \Omega,\\ u>0 & \text{in}\ \Omega,\\ u=0 & \text{on}\ \partial \Omega, \end{cases} \]
where $L(v)=-\textrm {div}(M(x)\nabla v)$ is a linear operator, $p\in (2,2^{*}]$ and $\lambda$ and $m$ sufficiently large. Then their asymptotical limit as $m\to +\infty$ is investigated showing different behaviours.
THE ‘POLITE’ AORIST: TENSE OR ASPECT?
Authors: Nijk Arjan A.
Published: September 2021

This article investigates the semantics and pragmatics of the ‘hortative’ aorist (the aorist indicative in questions with τί οὐ ‘why don't …’) and the ‘tragic’ or ‘performative’ aorist (for example ὤμοσα ‘I swear’). Lloyd argued in 1999 that the tragic aorist is a more polite alternative for the corresponding present (ὄμνυμι ‘I swear’). Recently, he has extended this view to the hortative aorist, suggesting that, for example, τί οὐκ ἐκαλέσαμεν; is a polite alternative for τί οὐ καλοῦμεν; Lloyd argues that the politeness value of the aorist derives from its being a past tense, comparing the so-called ‘attitudinal’ past (as in I wanted to ask you something instead of I want to ask you something). The present article, building on work by Colvin, Bary and Nijk, argues instead that the semantic value of the aorist is purely aspectual in these cases: the hortative and tragic aorists serve to construe the designated event as bounded, while the corresponding present forms serve to construe the designated event as unbounded. An extensive discussion of the evidence for the hortative aorist and present is presented, as well as a case study concerning the aspectual behaviour of the verb ὄμνυμι. Moreover, I argue that the proposed semantic account of the hortative and tragic aorists in terms of aspect can be unified with Lloyd's pragmatic account in terms of politeness: the difference in tone between the present and the aorist can be derived from their respective aspectual values, rather than from their temporal values.
Multidisciplinary team management of tracheostomy procedures in neurocritical care patients: our experience over 17 years in a quaternary centre
Authors: McClenaghan F , McGowan S , Platt L , Hunt K , Fishman J
Published: September 2021

Objective

Tracheostomy in the neurocritical care population is associated with poorer outcomes. This study hypothesised that a multidisciplinary approach to tracheostomy care can improve outcomes.

Methods

This study was a prospective longitudinal study of all tracheostomised patients in the neurocritical care units of a quaternary centre over 17 years. All patients were managed by a tracheostomy team with a constant core membership of an intensive care consultant, speech and language therapist, and physiotherapist with consultant ENT input.

Results

A total of 51 per cent of patients were decannulated in hospital at an average of 48 (neuromedical) and 57.6 (neurosurgical) days. Of the 42 per cent of patients transferred to another facility with a tracheostomy tube in situ, 37.5 per cent were at an advanced stage of tracheostomy weaning. Complication rates were low at 4.8 per cent with no tracheostomy associated mortalities.

Conclusion

A multidisciplinary approach can enable good outcomes in the neurocritical care population. Consistency of care spanning the step-down from critical to ward-level care is crucial to improving outcomes.
In SituMeasurement of Elastic and Frictional Properties Using Atomic Force Microscopy
Authors: Huynh Ngoc-Phat , Le Tuan-Em , Chung Koo-Hyun
Published: September 2021

Atomic force microscopy (AFM) can determine mechanical properties, associated with surface topography and structure, of a material at the nanoscale. Force–indentation curves that depict the deformation of a target specimen as a function of an applied force are widely used to determine the elastic modulus of a material based on a contact model. However, a hysteresis may arise due to friction between the AFM tip and a specimen. Consequently, the normal force detected using a photodetector during extension and retraction could be underestimated and overestimated, respectively, and the extension/retraction data could result in a significant difference in the elastic modulus measurement result. In this study, elastic modulus and friction coefficient values were determined based on an in situ theoretical model that compensated for the effect of friction on force–indentation data. It validated the proposed model using three different polymer specimens and colloidal-tipped probes for the force–indentation curve and friction loop measurements. This research could contribute to the accurate measurement of mechanical properties using AFM by enhancing the interpretation of force–indentation curves with friction-induced hysteresis. Furthermore, the proposed approach may be useful for analyzing in situ relationships between mechanical and frictional properties from a fundamental tribological perspective.
KHOVANOV SPECTRA FOR TANGLES
Authors: Lawson Tyler , Lipshitz Robert , Sarkar Sucharit
Published: September 2021

We define stable homotopy refinements of Khovanov’s arc algebras and tangle invariants.
Porosity and Compaction State at the Active Pāpaku Thrust Fault in the Frontal Accretionary Wedge of the North Hikurangi Margin
Authors: Dutilleul Jade , Bourlange S. , Géraud Y.
Published: September 2021

Characterization of the porosity evolution across the sedimentary section entering subduction zones and accreted sediments provide valuable information for understanding the deformation history at accretionary margins and the physico‐chemical processes in and around fault zones. International Ocean Discovery Program Expeditions 372 and 375 drilled, logged, and cored the reference section on the incoming plate (Site U1520) and across the active Pāpaku thrust (Site U1518), which is a <30° westward‐dipping splay fault in the frontal accretionary wedge at the north Hikurangi margin in a region where tsunami earthquakes and recurrent slow slip events are documented. We observe strong variations of physical properties across the thrust fault. In particular, interstitial porosity increases by ∼10% through the fault zone while it exponentially decreases with depth, showing lower values in the hanging‐wall (HW; on average, ∼36%) than in the footwall (∼42%). Based on comparisons of porosity with the compaction curve at Site U1518 with that of reference Site U1520, we infer an overcompaction in the HW and a nearly normal compaction in the footwall of the Pāpaku thrust. We suggest that the porosity pattern across the thrust infers differences in the maximum burial depth of sediments, characterized by an overcompacted HW that has been uplifted, thrusted, and concomitantly tectonically eroded above the footwall. Porosity data indicate hydrostatic conditions around the thrust fault contrasting with commonly assumed excess pore pressure at the plate interface.
Nitrate Transport and Retention in Western European Catchments Are Shaped by Hydroclimate and Subsurface Properties
Authors: Ehrhardt Sophie , Ebeling Pia , Dupas Rémi , Kumar Rohini , Fleckenstein Jan H. , Musolff Andreas
Published: September 2021

Excess nitrogen (N) from anthropogenic sources deteriorates freshwater resources. Actions taken to reduce N inputs to the biosphere often show limited or only delayed effects in receiving surface waters hinting at large legacy N stores built up in the catchments' soils and groundwater. Here, we quantify transport and retention of N in 238 Western European catchments by analyzing a unique data set of long‐term N input and output time series. We find that half of the catchments exhibited transport times with an average riverine concentration peak arriving 5 years after application. Longer transport times were evident in catchments with high potential evapotranspiration and low precipitation seasonality. On average the catchments retained 72% (Interquartile Range: 18%) of the N from diffuse sources with retention efficiency being specifically high in catchments with low discharge and thick, unconsolidated aquifers. The estimated transport time scales do not explain the observed N retention, suggesting a dominant role of biogeochemical legacy in the catchments' soils rather than a legacy store in the groundwater. Future water quality management should account for the accumulated biogeochemical N legacy by fostering denitrifying conditions or soil N recycling to avoid long‐term leaching and water quality deteriorations for decades to come.
Searching for Subsurface Oceans on the Moons of Uranus Using Magnetic Induction
Authors: Weiss Benjamin P. , Biersteker John B. , Colicci Vittorio , Goode Allison , Castillo‐Rogez Julie C. , Petropoulos Anastassios E. , Balint Tibor S.
Published: September 2021

The icy moons of Uranus may contain subsurface oceans. Such oceans could be detected and characterized using measurements of magnetic fields induced by Uranus' time‐varying magnetospheric field. Here we explore this possibility for Uranus's five major moons, with a focus on Ariel. We find that the magnetic field at each moon is dominated by the synodic frequency with amplitudes ranging from ∼4 nT at Oberon up to ∼300 nT at Miranda. If these bodies contain oceans with sufficient thicknesses (>∼0.4–6 km) and conductivities (>2 S m−1) even underlying relatively thick (∼50 km) ice shells, the induced surface fields should have amplitudes exceeding the typical ∼1 nT sensitivity of spacecraft magnetometry investigations. Furthermore, the magnetic field variations at the moons span periods ranging from 1 to 103 h. These could enable long‐term measurements to separately constrain ocean and ice thicknesses and ocean salinity.
Active Boulder Falls in Terra Sirenum, Mars: Constraints on Timing and Causes
Authors: Grindrod Peter M. , Davis Joel M. , Conway Susan J. , de Haas Tjalling
Published: September 2021

We use time series images to identify significant active boulder falls in an impact crater on Mars. Evidence for active boulder falls include boulder trails with impact marks from bouncing and rolling, and dark patches from boulder impacts away from the base of the crater walls. We were able to define three time periods with active boulder falls and additional slope streak formation, for which we refined the most significant activity to a time period between January 2012 and March 2013. A search of 236 images within 500 km of the study site identified two further sites with similar, but reduced, activity during the same time period. We discuss plausible mechanisms for the boulder fall activity, and conclude that the local geology and crater age is likely to be of significant importance. Our method of identifying and highlighting such activity will allow further studies of active surface processes on Mars.