bluuebunny/crossref_metadata_2025 huggingface dataset:
A Simple and Feasible Quantification of Metabolites in the Human Follicular Fluid Using 1H HR-MAS NMR Spectroscopy
Authors: MUMCU Akın
Published: December 2021

This study presents a reliable method for the quantification of metabolite concentrations in follicular fluid with the high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and the ERETIC2 (Electronic REference To access In vivo Concentrations) based on PULCON (pulse length based concentration determination) principle. The positive effect of the HR-MAS probe technology on spectral quality and its ability to perform analyses with very low sample amounts were the most important factors of proposing this method. In evaluating the performance of the proposed method, standard creatine solutions in different concentrations containing DSS (2,2-dimethyl-2-silapentane-5-sulfonate sodium salt) as an internal reference standard were analyzed using different pulse programs (cpmgpr1d and zg30). The results obtained with the ERETIC2 were compared with the classical internal standard NMR quantification method (DSS method). The relative standard deviation (RSD) values for ERETIC2 were in the range of 0.3% - 5.7% and recovery values were calculated as minimum 90.3%, while RSD values for DSS method were in the range of 0.1% - 3.1% and recovery values were minimum 97.0%. Besides, it was observed that the metabolite concentration values calculated using the ERETIC2 procedure of follicular fluid samples obtained from the women with endometriosis and healthy controls were compatible with the values those obtained using different methodologies. The obtained results showed that the proposed quantification method based on the HR-MAS spectroscopy can easily be used in biological fluids and therefore it can be utilized as a good alternative to the internal standard method considering its accuracy and precision.
Frontline Response to High Impact Domestic Violence in France
Authors: Tillous Marion , Delpeuch Thierry , Bonnet François
Published: December 2021

Since the 2000s, several laws have been enacted by the French parliament to make domestic violence a crime taken more seriously. Among the most important developments, a 2010 bill introduced the protection order in French law; the inter-ministerial mission for the protection of women against violence and the fight against human trafficking (MIPROF) was created in 2013, and a set of conferences between public stakeholders and NGOs took place in 2019 (the "Grenelle des violences conjugales"). In France, policies to combat domestic violence at the local level essentially rely on the setting and diffusion of two types of organisational arrangements. The first type of arrangement is a specialised domestic violence unit that is set up within a larger organisation with a more general mission, such as law enforcement agencies, hospitals, or social services. The second type of arrangement is an inter-organisational structure intended to provide a framework for partnership cooperation against domestic violence, such as social workers embedded in police stations to provide expert assistance to victims when they report domestic violence.
Policy Development Module
Authors: October Martta , Nipuli Suvi
Published: December 2021

The Policy Development Module aims to make the Domestic Violence combatting policy planning process more structured and inclusive. The Checklist and Manual developed during IMPRODOVA research andinnovation project form together a tool designed for Policy drafters, decision-makers and other key professionals responsible for planning the Policy's Feedback Cycle on national and local levels. This PolicyDevelopment tool enables a critical examination of relevant information and helps to consider all viable policy perspectives and tools, leading to increased understanding between different professions. Itmakes the Policy planning more inclusive and aids in engaging all salient stakeholders, including the representatives of the practitioners who work at the front-line and implement the policy. Consequently, theparticipants will develop a common purpose and a shared view on tackling the multidimensional societal challenges posed by Domestic Violence. The Checklist consists of eight sections, each of which shouldbe noted when drafting a new policy document and planning the indicators for its follow-up. The Manual gives more details and practical examples of each section and therefore supports the use of theChecklist.
Frontline Response to High Impact Domestic Violence in Austria
Authors: Herbinger Paul , Neinkirchner Marion , Leonhardmair Norbert
Published: December 2021

The networked response to cases of high-impact domestic violence in Austria predominantly involves four groups of actors, who share both formal and informal modes of interagency cooperation, and each function as independent entry points to a networked intervention. These groups consist of specialised and non-specialised police officers, a number of NGOs in the social sector, regional administration and municipal authorities, as well as the medical sector, predominantly involving hospital staff. The most important legal measure in place for the protection of victims by police is the restraining order in the Security Police Act, which was introduced as part of the victim protection guidelines. A unified and universally applied definition of domestic violence does not exist in Austria. As a result, there is no cross-sectoral standardisation when identifying violent acts. Nevertheless, the networked response in Austria is characterized by a robust system of inter-agency referrals and formalized cooperation.
Effects of packaging and storage conditions on quality of spider plant (Cleome gynandara L.) seed
Authors:   Karatina University, Kenya, Kamotho GN , Mathenge PW , Muasya RM ,   South Eastern Kenya University, Dulloo ME ,   Bioversity International, Italy
Published: December 2021

In Kenya, spider plant (Cleome gynandra L.) has gained popularity among consumers due to its nutritional and medicinal values. In the local markets, bundles of leafy shoots as well as uprooted young plants are offered at fairly high prices in many parts of Kenya. Existing evidence suggests that spider plant is endowed with higher level of nutrients than its exotic counterparts. The leaves contain over and above the normal recommended adult daily allowance of vitamins A and C, calcium and iron. However, quality of spider plant seed is affected by one or more factors that cause negative response during seed handling and storage. The purpose of this research was to increase insight into how the seed quality of spider plant is affected by different packaging containers, seed moisture content and storage temperatures, with a view to finding out the optimal method of packaging and storing of these seeds. This study was carried out using seeds dried above silica gel to four target moisture levels: 20%, 10%, 5% and 2% moisture content. Dried seeds were sealed in aluminum foil packets and polyethylene packets and stored at three storage temperatures: ambient (22oC to 30oC), 5oC and minus 20oC for three and six months. After each storage period, seed samples were drawn and viability and vigour tests carried out. Data sets were factorially combined and subjected to Analysis of Variance (ANOVA)and descriptive analysis. Means separation was by Least Significance Difference (LSD).Levels of significance, means and standard deviations were obtained for various data sets. Seed stored for six months at 5% moisture content and minus 20oC recorded the highest seed quality. There were no significant differences between seeds packaged in aluminum foil packets and polyethylene packets. In this study, a germination of 85% was recorded for seed dried to 5% moisture content and stored at room temperature. Therefore, on the basis of these findings, farmers can dry their seeds at about 5% moisture content, package them in polyethylene (since readily available) and store at room temperatures for six months.
Lack of dietary sources of iodine and the prevalence of iodine deficiency in rural women from Sidama zone, southern Ethiopia
Authors:   Hawassa University, Ethiopia, Gebreegziabher T , Teyike N ,   Sidama Zone Health Bureau, Hawassa, Ethiopia, Mulugeta A ,   Mekele University, Tigray, Ethiopia, Abebe Y ,   Hawassa University, Ethiopia, Hambidge KM ,   University of Colorado, Denver, CO, USA, Stoecker BJ ,   Sidama Zone Health Bureau, Hawassa, Ethiopia
Published: December 2021

Iodine deficiency has been reported to affect a large number of people in Ethiopia. Although significant progress against iodine deficiency disorders (IDD) has been reported worldwide, millions of people remain with insufficient iodine intake. Multiple factors may contribute to iodine deficiency. Hence, the objective of this study was to investigate iodine deficiency and dietary intake of iodine. A cross-sectional survey design was used to assess urinary iodine concentration (UIC), goiter and dietary intake of iodine in a sample of 202 non-pregnant women living in three rural communities of Sidama Zone, southern Ethiopia. Urinary iodine concentration was analyzed using the Sandell-Kolthoff reaction, goiter was assessed using palpation and dietary source of iodine was assessed using a food frequency questionnaire. Data were analyzed using selected descriptive and analytical statistical measures with SAS software. Mean (SD) age, mid upper arm circumference (MUAC) and body mass index [BMI -Wt(kg)/(Ht(m))2] were 30.8(7.9) y, 24.8(2.5) cm and 20 (2.2) respectively. Median UIC was 37.2 µg/L. Participants with UIC <20 µg/L, classified as severely iodine deficient were 22.8%; 46.5% had UIC between 20 to <50 µg/L, classified as moderately iodine deficient, and 27.2 % had UIC in the mild deficiency range of 50 to <100 µg/L. Only 3.5% of the women had UIC ≥ 100 μg/L. The total goiter rate was 15.9%, which was 1.5% visible and 14.4% palpable goiter. A majority of the participants consumed Enset (E. ventricosum), corn and kale frequently and meat was consumed rarely. None of the participants reported ever consuming iodized salt or ever having heard about use of iodized salt. Adjacent communities (Alamura, Tullo and Finchawa) showed significant differences in UIC, goiter rate and frequency of fish and dairy consumption. The findings of the present study revealed that iodine status of the population is a significant public health problem. Hence, there is a need to supply iodized salt in order to achieve the goal of elimination of iodine deficiency disorders in the community.
El refugio cultural festival, graffiti and urban art in the historic centre of Puebla in Mexico
Authors: Jiménez Gustavo Valencia , Hernández Sánchez Adriana , De La Torre Sánchez Christian Enrique
Published: December 2021

The city of Puebla was put on the UNESCO list of Cultural Heritage of Humanity in 1987; its history dates back to the sixteenth century allowing for the preservation of various important buildings, such as churches with baroque and neoclassical facades, buildings from the period known as Novo Hispanics, when some of its historic neighbourhoods were founded, including the Barrio el Refugio, hereinafter referred to as BR, where indigenous people employed in the lime manufacture used to live. Since those times, however, the neighbourhood has become a place with bad reputation, “a den of thieves” (Leicht). The traditional, religious commemoration, the “Fiesta Patronal de la Virgen del Refugio,” is the most important celebration in the neighbourhood. In the Church of La Virgen del Refugio, built in the seventeenth century after an inhabitant painted a mural with the image of the virgin, the “mañanitas” are sung with the Mariachi. During the patronal feast, the “El Refugio Cultural Festival” is held with more than a hundred artists taking part and creating about a thousand murals according to the organiser’s estimation. This happens in the city where a project “Puebla Ciudad Mural” was started, as an initiative of the “Colectivo Tomate,” which sought to regenerate the neighbourhood through art, in alliance with the government and private companies. However, these policies are more tourist oriented rather than benefit the neighbourhood. For this reason, the graffiti movement “Festival Cultural el Refugio” is becoming a meeting point for urban artists from Mexico and Puebla, accustomed to taking up public or private space, as they demand space where they can live and express themselves. For ten years the festival has realised more than one thousand pieces of urban art, including Wild Style graffiti, bombs, stickers, stencil, and murals. All this is done under the patronage of the artists themselves, as three hundred of them come from all over the country to take part in every edition of the festival that does not receive any government support or other form of sponsorship.
The Ambiguity of Everyday Experience: Between Normality and Boredom
Authors: Misztal Barbara A.
Published: December 2021

This paper asserts that the growing expansion of the micro realm of social activity calls for the exploration of everyday experience, seen as ranging from the most extraordinary to the most ordinary. The paper focuses on two constitutive features of the ordinary type of experience, namely, normality and boredom. It conceptualizes normality as an outcome of people’s potential to construct meaning of their ordinary experiences and boredom as a state signaling our inability to realize this desire. Both types of ordinary experience are in the core of everyday life and thus their consequences can be detrimental to the quality of social life. This paper’s discussion of normality and boredom includes both sociological and literary works where these two phenomena find their rich expression.
100 éve született – egy éve hunyt el Dr. Nagy Barnabás (1921–2020)
Authors: Szövényi Gergely
Published: December 2021

2020. június 27-én, 99 éves korában elhunyt Dr. NAGY BARNABÁS zoológus, és egy év elteltével már születésének századik évfordulójára emlékezünk. Igen hosszú, eredményekben gazdag tudományos életpályája a növényvédelmi rovartan és a közép-európai orthopterológia megkerülhetetlen alakjává tette.
Dr. Merkl Ottó emlékezete (1957–2021)
Authors: Szél Győző
Published: December 2021

2021. február 19-én, 64 éves korában elhunyt Dr. MERKL OTTÓ zoológus, entomológus, a Magyar Természettudományi Múzeum főmuzeológusa, a hazai rovartan kiemelkedő alakja, a katicabogarak (Coccinellidae) és a gyászbogarak (Tenebrionidae) nemzetközileg is elismert szakértője. Személyében egy sokoldalú, nagy műveltségű, fáradtságot nem ismerő természettudós távozott közülünk, aki muzeológusként a tudományban és az ismeretterjesztésben egyaránt maradandót alkotott (VIG 2020, 2021).
Complaints of Musculoskeletal Disorders on Sales Promotion Girl at Cosmetic Stores in Surabaya, Indonesia
Authors: Mawaddah Salsa Daffania , Widajati Noeroel
Published: December 2021

Highlight:Standing position duration and shoe characteristics to MSDs's complaints  on sales promotion girls at cosmetic stores in Surabaya were analyzed.There was no correlation between height of heels with complaints of MSDs and shoe type, while, the duration of standing position and complaints of MSDs were correlated. Abstract:One of the occupations that have a risk of Musculoskeletal Disorders (MSDs) is sales promotion girl (SPG), especially the SPG at a cosmetic store, because their job position is mostly done by standing and wearing high heels. This study aimed to analyze the correlation between duration of standing position and shoe characteristics to complaints of MSDs on sales promotion girl at cosmetic stores in Surabaya. This study was quantitative research with observational analytic research, where the data collection was carried out by cross-sectional. This research was conducted at 21 cosmetic stores from three shopping centers in Central Surabaya. The population in this study was 64 SPG. The sample was taken using simple random sampling with exclusion criteria, so that 47 people were obtained. The independent variables consisted of duration of standing position and shoe characteristics included shoe type and the height of heels. The dependent variable was complaint of MSDs. The data analysis was carried out using the Spearman correlation test. The result showed that there was a correlation between the duration of standing position and complaints of MSDs (Pvalue=0.011; r=0.369; positive direction), no correlation between shoe type and complaints of MSDs (Pvalue=0.735; r=0.051; positive direction), and no correlation between the height of heels and complaints of MSDs (Pvalue=0.256; r=0.169; positive direction). It was concluded that there was a correlation between the duration of standing position and complaints of MSDs, and there was no correlation between shoe type and the height of heels with complaints of MSDs.
Poedji Rochjati Score Card as Media for Preconception Counseling
Authors: Simanungkalit Naomy , Handayani Samsriyaningsih , Akbar Muhammad Ilham Aldika
Published: December 2021

Highlight:The PCC counseling effect using Poedji Rochjati Score Card (PRSC) on premarital knowledge about high-risk pregnancies was studied.PRSC for preconception counseling is effective for women to improve knowledge about high-isk pregnancy.Abstract:Preconception care (PCC) is a health approach that includes promotive and preventive activities to detect risk factors and interventions carried out to expectant mothers by considering biological, behavioral, and social aspects that affect their health. This study studied the effect of PCC counseling using Poedji Rochjati Score Card (PRSC) on premarital knowledge about high-risk pregnancies. This study was quasi-experimental with 52 respondents divided into 4 groups, namely intervention and control groups, 2 groups with partners, and 2 groups without partners that were chosen through total sampling by applying inclusion and exclusion criteria. Knowledge was measured using pretest and posttest questionnaires. The intervention given was in the form of counseling using PRSC for ± 20 minutes. There were differences in knowledge between the intervention and control group among respondents without partners. Preconception counseling using PRSC was effective for women attending premarital health checks. Applying PRSC as media for counseling could improve knowledge in high-risk pregnancy that could be avoided.
Prostitusi Online Sebagai Tindak Pidana Perdagangan Orang
Authors: Muhtadi Afif Fathin
Published: December 2021

AbstractCriminal law in Indonesia specifically does not regulate online prostitution. However, in several court decisions, online prostitution is often linked to the crime of human trafficking because online prostitution involving pimps fulfills the elements of the criminal act of human trafficking as stated in Law No. 21 of 2007 concerning the Eradication of the Crime of human trafficking. This raises the question of what elements cause a pimp can be said to have fulfilled the element of the criminal act of human trafficking and whether sexual consent by a commercial sex worker can erase the criminal element of a pimp. Therefore, in this paper, the authors discuss further the elements of sexual exploitation and consent to victims of human trafficking using online prostitution.Keywords: Online Prostitution; Human Trafficking; Criminal Act.AbstrakHukum pidana di Indonesia secara khusus tidak mengatur terkait prostitusi secara online. Namun, dalam beberapa putusan pengadilan, prostitusi online sering kali dikaitkan kepada tindak pidana perdagangan orang dikarenakan prostitusi online yang melibatkan muncikari memenuhi unsur-unsur tindak pidana perdagangan orang sebagai mana tercantum dalam Undang-Undang No 21 Tahun 2007 Tentang Pemberantasan Tindak Pidana Perdagangan Orang. Hal tersebut menimbulkan pertanyaan mengenai unsur apa yang menyebabkan seorang muncikari dapat dikatakan telah memenuhi unsur perbuatan tindak pidana perdagangan orang dan apakah persetujuan seksual oleh pekrja seks Komersial dapat menghapus unsur pidana seorang muncikari. Oleh karena itu, dalam penulisan ini, penulis membahas lebih jauh terkait unsur eksploitasi dan persetujuan seksual (sexual consent) terhadap korban tindak pidana perdagangan orang dengan modus prostitusi online.Kata Kunci: Prostitusi Online; Perdagangan Orang; Tindak Pidana.
Perusahaan Judi Online Sebagai Sponsor Klub Sepak Bola Profesional di Indonesia Ditinjau dari Aspek Hukum Pidana
Authors: Elfaza Annisa Gista
Published: December 2021

AbstractProfessional sports are sports that are organized to get income from a skill. One of the most popular sport is football. In Indonesia, the Local Government Budget is not allocated to the professional football club. So, the professional football club establishes sponsorship collaboration with other agencies. For example, in league 1 2020 Indonesia’s football competition, there was a cooperation between a professional football club with an initial “PSKB” and an online gambling site with an initial “S” as a sponsorship partner. Reviewed by a criminal law aspect, it can cause a problem because there’s an indication violates a positive law in Indonesia. The result of the study research showed that the club’s action potentially violates Article 27 paragraph (2) Law Concerning Information and electronic transactions because the club promoted a thing aim to information about online gambling. Criminal responsibility can be imposed on the club as a corporation and/or director.Keywords: Professional football club; Online Gambling site; Sponsorship; Social Media; Corporation.AbstrakOlahraga professional merupakan olahraga yang diperuntukan untuk memperoleh pendapatan dalam bentuk uang atau lainnya atas kemaharian berolahraga. Kepopularitasan sepakbola sebagai salah satu olahraga yang digemari. Di Indonesia pendanaan sepak bola professional tidak diperoleh dari APBD, sehingga klub sepak bola professional mendapatkan dana dengan salah satu cara yaitu menjalin kerjasama sponsorship dengan pihak lain. Sebagai contohnya pada penyelenggaraan Liga 1 tahun 2020 sebagai kompetisi sepak bola, adanya kerjasama sponsorship yang dijalin antara klub sepak bola professional berinisial “PSKB” dengan situs judi online berinisial “S”. Hal tersebut apabila ditinjau dari aspek hukum pidana dapat menimbulkan permasalahan dimana terdapat indikasi atau potensi melanggar aturan hukum positif di Indonesia. Hasil penelitian penulis menunjukan Perbuatan klub tersebut dapat berpotensi melanggar ketentuan Pasal 27 ayat (2) UU ITE, dikarenakan klub tersebut mempromosikan hal yang mengarah pada informasi yang memuat perjudi online. Serta, pertanggungjawaban pidananya dapat dibebankan kepada pengurus dan/atau korporasi. Kata Kunci: Klub Sepak Bola Profesional; Situs Judi Online; Sponsorship; Sosial Media; Korporasi.
Aspek Hukum Pidana Penyiaran Film Tanpa Sensor oleh Netflix Sebagai Penyedia Layanan Subscription Video On Demand
Authors: Ulya Aushofi Zuhrotul
Published: December 2021

AbstractThe new broadcast media is broadcast digitization in the form of a platform accessed via the internet network. Netflix as a provider of the Subscription Video on Demand service broadcasts uncensored films which result in the films being against the culture and laws and regulations in Indonesia because they contain pornography to violence even though there is an obligation to be censored by a film before the film will be shown. This research is a legal research that analyzes the uncensored film broadcasting activities carried out by Netflix according to the laws and regulations in Indonesia and Netflix's legal liability for uncensored film broadcasting by using a statutory approach and a conceptual approach. From this research it was found that Netflix broadcasts uncensored films in Indonesia in violation of the statutory provisions concerning Broadcasting, Film, Pornography, and ITE. However, Netflix does not automatically account for all provisions of the laws and regulations because the locus of broadcasting activities carried out by Netflix cannot be reached by all the provisions of the laws and regulations.Keywords: Film Broadcasting; Netflix; Film Censorship; Internet.AbstrakMedia penyiaran baru merupakan digitalisasi penyiaran dalam bentuk platform yang diakses melalui jaringan internet. Netflix sebagai penyedia layanan Subscription Video on Demand menyiarkan film tanpa sensor yang mengakibatkan filmnya bertentangan dengan budaya dan peraturan perundang-undangan di Indonesia karena bermuatan pornografi hingga kekerasan padahal terdapat kewajiban untuk dilakukan sensor film dikeluarkan oleh lembaga sensor film sebelum film akan dipertunjukkan. Penelitian ini merupakan penelitian hukum yang menganalisis kegiatan penyiaran film tanpa sensor yang dilakukan oleh Netflix menurut peraturan perundang-undangan di Indonesia dan pertanggungjawaban hukum Netflix terhadap penyiaran film tanpa sensor dengan mengggunakan pendekatan undang-undang dan pendekatan konseptual. Dari penelitian ini ditemukan bahwa Netflix melakukan penyiaran film tanpa sensor di Indonesia melanggar ketentuan peraturan perundang-undangan tentang Penyiaran, Perfilman, Pornografi, dan ITE. Namun, tidak serta merta semua ketentuan peraturan perundang-undangan yang dilanggar dapat dipertanggungjawabkan pada Netflix karena locus kegiatan penyiaran yang dilakukan oleh Netflix tidak dapat dijangkau semua ketentuan peraturan perundang-undangan. Kata Kunci: Penyiaran Film; Netflix; Sensor Film; Internet.
Pertanggungjawaban Pidana Pelaku Tindak Pidana dalam Transaksi Jual Beli Pornografi di Media Internet
Authors: Qois Ghozi Naufal
Published: December 2021

AbstractPornography has become a material for sale and purchase transactions. Pornographic transactions on the internet have many processes , so that there are many laws and regulations that can be applied. This creates legal uncertainty. The formulation of the problem in this research is the qualification of criminal acts related to pornography selling and buying transactions on the internet media and the accountability of criminals in selling and buying pornography on the internet media. The research method used is legal research through a conceptual approach and a statutory approach to assess existing legal problems. The results of this study show that the sale and purchase of pornography via the internet can be applied to the ITE and pornography laws. Then the responsibility depends on the evidence in the process of proving in court what the form of pornography is.Keywords: Criminal Liability; Transactions; Buying and Selling; Pornography; Internet.AbstrakPornografi sudah menjadi bahan yang di transaksi jualbelikan. Transaksi pornografi di media internet memiliki banyak proses seperti penawaran, kesepakatan, penyerahan barang, dan pembayaran sehingga terdapat banyak peraturan perundang-undangan yang dapat diterapkan. Hal ini membuat ketidak pastian hukum. Rumusan masalah dalam penelitian ini adalah Kualifikasi tindak pidana terkait transaksi jualbeli pornografi di media internet dan pertanggungjawaban pelaku tindak pidana dalam transaksi jualbeli pornografi di media internet. Metode penelitian yang digunakan adalah legal research dengan melalui pendekatan konseptual dan pendekatan peraturan perundang-undangan untuk mengkaji permasalahan hukum yang ada. Hasil dari penelitian tersebut diketahui bahwa transaksi jualbeli pornografi melalui internet dapat diterapkan Undang-Undang ITE dan Pornografi. kemudian pertanggungjawabannya tergantung dari pembuktian dalam proses pembuktian di dalam persidangan apakah bentuk dari pornografi tersebut.Kata Kunci: Pertanggungjawaban Pidana; Transaksi; Jual Beli, Pornografi; Internet.
Regulasi Bagi Pengendara Skuter Listrik dan Otoped Listrik di Indonesia
Authors: Hasibuan Ramadhan Henrison
Published: December 2021

AbstractThis research aims to determine the existing regulations in Indonesia for motorists and the use of electric scooters on the road. At the beginning of its appearance, there were no clear regulations regulating provisions for electric scooters so that users can ride these transportation freely, causing conflicts between electric scooters user with pedestrians and other vehicle user. Conflicts that occur between electric scooters user and pedestrians include pedestrians who consider the use of electric scooters on sidewalks and pedestrian bridges to endanger pedestrians, while electric scooters are too slow to be used on the road with other vehicle riders. So that it can be dangerous. This article is hoped to be able to answer the regulations that must be obeyed by electric scooters user when driving on the road.Keywords: Electric Scooter; Conflict; Regulation.AbstrakPenelitian ini bertujuan untuk mengetahui regulasi yang ada di Indonesia bagi pengendara dan pemakaian kendaraan jenis otoped listrik dan skuter listrik di jalan raya. Pada awal kemunculannya belum ada regulasi yang mengatur secara jelas mengenai ketentuan bagi para pengendara skuter listrik dan otoped listrik sehingga pengguna mengendarai alat trasnportasi tersebut secara bebas hingga menimbulkan konflik antara pengendara skuter listrik dan otoped listrik dengan pejalan kaki dan pengendara kendaraan lainnya. Konflik yang terjadi antara pengendara skuter listrik dan otoped listrik dengan pejalan kaki anatara lain adala pejalan kaki menganggap penggunaan otoped listrik dan skuter listrik di trotoar dan jembatan penyebrangan membahayakan pejalan kaki sedangkan dengan pengendara kendaraan lainnya pengemudi skuter listrik dan otoped listrik terlalu lambat berjalan di jalan raya sehingga dapat membahayakan. Artikel ini diharapkan dapat menjawab regulasi yang harus dipatuhi oleh pengendara skuter listrik dan otoped listrik ketika berkendara di jalan raya.Kata Kunci: Skuter listrik; Otoped Listrik; Konflik; Regulasi.
Tourism product differentiation strategy in the Zante island based on thematic routes and the use of information communication technology
Authors: Curtis Panayiotis , Mylonakis John , Ktenidis Takis
Published: December 2021

The unsatisfactory performance of tourism on Zante Island in Greece, expressed by low return on equity capital of hotels of the island, is due to the mass tourism product. The SWOT analysis is used as a tool of strategy analysis of the internal and external environment to describe the present situation of tourism on the island. Results show that the best strategy to achieve and promote competitiveness is to differentiate the product, ameliorate its quality and the use of Information Communication Technology, in order to decrease seasonality, prolong the annual period of tourism operations and connect it to the rest of the economy on the island. The case study of defining thematic routes for tourism in Zante by the local communities is an example of decisive contribution of the product differentiation to sustainable development of rural and less favorite areas.
The role of logistics information system in the business-decision process
Authors: Galicic Vlado , Pilepic Ljubica
Published: December 2021

The development of logistics information systems that support decision-making, together with the use of business intelligence, provides assistance and support to logistics managers in the decision process, thereby impacting on the quality of business and productivity. Being better informed and having greater intelligence for decision-making can help to create new value and gain competitive advantage. Logistics business systems in a tourism destination appreciate the importance of information and communication technology in the decision process and seek to develop efficient logistics information systems that will make it possible to take better and more appropriate decisions directly aimed at improving business efficiency and productivity.
BEM JURÍDICO PENAL E CULTURA EM CARLOS COSSIO: FUNDAMENTOS TEÓRICOS PARA A REFORMULAÇÃO TÍPICA DO ART.268 CÓDIGO PENAL
Authors: Carneiro Yuri Castro
Published: December 2021

Em virtude da inevitabilidade de uma construção dogmática penal teleologicamente destinada a consecução de um Estado Democrático de Direito capaz de coexistir com um Direito Penal compatível com a dignidade da pessoa humana, torna-se salutar a existência do que a academia denomina de Bem Jurídico – Penal, deste modo, foi abordado uma perspectiva evolucionista das noções de Bem Jurídico-Penal, para que se possa teorizar acerca da função do Bem Jurídico e sua influência quanto aos efeitos jurídicos da Covid-19 no Brasil. Após a abordagem histórica, pormenoriza-se a teoria egológica de Carlos Cóssio, detalhando sua perspectiva axiológica do direito e os reflexos que a temporalidade, somada com as novas necessidades da sociedade podem/devem influenciar nas normas vigentes, em relação manifesta com a teoria tridimensional do direito. Tal estudo tem o condão de pautar na realidade nacional uma possível modificação do art. 268 do Código Penal tendo em vista a salvaguarda do ordenamento nacional e a compatibilização sistemática que deve haver em nosso sistema jurídico.
O PRINCÍPIO DA DIGNIDADE DA PESSOA HUMANA E O DIREITO À EDUCAÇÃO: UMA ANÁLISE SOB A ÓTICA DA SOCIEDADE DE RISCO
Authors: Pereira Wellington Gustavo , Soares Gabrielle Valeri
Published: December 2021

Este estudo analisa os desafios que a observância prática do princípio da dignidade da pessoa humana encontra na sociedade de risco de Ulrich Beck, bem como a necessidade do surgimento de uma nova ética capaz de balizar as ações humanas, cujas consequências extrapolam as noções usuais e simultâneas de tempo e espaço. Na forma de um exemplo sintético, pretende-se pensar o Direito à Educação em face da teoria de Beck, com diálogos com Hannah Arendt e José Sérgio Fonseca de Carvalho. Ademais, a presente pesquisa verifica que a efetividade dos direitos humanos está sujeita a diversos obstáculos, tais como: a ausência de tutela internacional efetiva, a presença de critérios vagos para a resolução de conflitos entre os direitos fundamentais relativos e a necessidade de especificação dos direitos humanos já existentes. A metodologia utilizada compreende uma abordagem qualitativa, dialética, de natureza básica, contendo um objetivo explicativo e um procedimento bibliográfico, documental, histórico e observacional. Os resultados da pesquisa realizada apontam que a problemática erigida somente pode ser solucionada mediante uma resposta transdisciplinar, amparada pelo paradigma da complexidade de Edgar Morin, além de frisar a necessidade de uma maior participação dos Estados em organizações internacionais. Por fim, a pesquisa também apontou que os critérios construídos pelo neoconstitucionalismo podem servir de base para o deslinde de eventuais choques entre os direitos fundamentais relativos.
Development of a sand boil testing laboratory and preliminary results
Authors: Stephens Isaac , Robbins Bryant , Keffer Andrew
Published: December 2021

To document the purpose, use, and preliminary results of a full-scale sand boil generator developed at the Geotechnical and Structures Laboratory.
Deep Learning-Based Fast TOF-PET Image Reconstruction Using Direction Information
Authors: Ote Kibo , Hashimoto Fumio
Published: December 2021

Deep learning has attracted attention for positron emission tomography (PET) image reconstruction task, however, it remains necessary to further improve the image quality. In this study, we propose a novel CNN-based fast time-of-flight PET (TOF-PET) image reconstruction method to fully utilize the direction information of coincidence events. The proposed method inputs view-grouped histo-images into a 3D CNN as a multi-channel image to use the direction information of coincidence events. We evaluated the proposed method using Monte Carlo simulation data obtained from a digital brain phantom. Compared to the case without it, when using direction information, the peak signal-to-noise ratio and structural similarity were improved by 1.2 dB and 0.02, at a coincidence time resolution of 300 ps. The calculation times of the proposed method were significantly faster than the conventional iterative reconstruction. These results indicate that the proposed method improves both the speed and image quality of TOF-PET image reconstruction.
Detachment-parallel recharge explains high discharge fluxes at the TAG hydrothermal field
Authors: Rüpke Lars , Guo Zhikui , Petersen Sven , German Christopher , Ildefonse Benoit , Hasenclever Jörg , Bialas Jörg , Tao Chunhui
Published: December 2021

Submarine massive sulfide deposits on slow-spreading ridges are larger and longer-lived than deposits at fast-spreading ridges1,2, likely due to more pronounced tectonic faulting creating stable preferential fluid pathways3,4. The TAG hydrothermal mound at 26°N on the Mid-Atlantic Ridge (MAR) is a typical example located on the hanging wall of a detachment fault5-7. It has formed through distinct phases of high-temperature fluid discharge lasting 10s to 100s of years throughout at least the last 50,000 years8 and is one of the largest sulfide accumulations on the MAR. Yet, the mechanisms that control the episodic behavior, keep the fluid pathways intact, and sustain the observed high heat fluxes of up to 1800 MW9 remain poorly understood. Previous concepts involved long-distance channelized high-temperature fluid upflow along the detachment5,10 but that circulation mode is thermodynamically unfavorable11 and incompatible with TAG's high discharge fluxes.
Here, based on the joint interpretation of hydrothermal flow observations and 3-D flow modeling, we show that the TAG system can be explained by episodic magmatic intrusions into the footwall of a highly permeable detachment surface. These intrusions drive episodes of hydrothermal activity with sub-vertical discharge and recharge along the detachment. This revised flow regime reconciles problematic aspects of previously inferred circulation patterns and can be used as guidance to one critical combination of parameters that can generate substantive mineral systems.
Plexciton Modes Guided by an Exciton Slab in a Columnar Thin Film
Authors: Rostami Mona , Babaei Ferydon
Published: December 2021

In this study, we reported plasmon-exciton coupling for excitation the surface plexciton in columnar thin film with a central exciton slab using the transfer matrix method in Kretschmann configuration. The optical absorption spectra for surface plasmon polariton, surface exciton and surface plexciton was investigated at different structural parameters in proposed structure. The characteristics of surface optical modes were analyzed and there was an anticrossing behavior between polariton branches of plexciton spectra. Localization of surface modes on interfaces and hybridization between plasmons and excitons at both interfaces of exciton slab were proved by the time-averaged Poynting vector. We found that the types of coupling regimes between plasmons and excitons from weak to strong could be achieved. We found a high Rabi splitting energy 840 meV corresponding to the time period 5 fs which includes to the fast energy transfer between surface plasmon polaritons and surface excitons.
Endovascular Thrombectomy for Acute Ischemic Stroke in the Filipino Population: A Clinical Experience From a Single Tertiary Center in Metro Manila, Philippines
Authors: Constantino Glenn Anthony , Senga Miguela Marie , Soliven Jo Ann , Jocson Victor Erwin
Published: December 2021

Background and Purpose

Throughout the years, stroke has remained one of the primary causes of significant morbidity and mortality. Among the therapeutic options for acute stroke management, endovascular thrombectomy intended to remove the thrombi within the intracerebral vasculature and restore adequate perfusion to the surrounding penumbra. It was recommended for eligible patients who were within 6—24 hours after the onset of neurologic symptoms. In the Philippines, only a few tertiary healthcare institutions were able to offer and perform endovascular thrombectomies. The aim was to describe the profile and discharge outcomes of endovascular thrombectomy for acute ischemic stroke at a tertiary hospital in our country.
Methodology:

In this retrospective study, 924 patients were admitted for acute ischemic stroke from October 2018 - August 2021. However, only 31 patients underwent mechanical thrombectomy and their records were thoroughly reviewed. Clinical and functional outcomes were measured using the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Score (MRS), respectively.
Results

Among the patients included in the study, 29 subjects (93.5%) had moderate to severe disability (MRS 3-5) and 17 (54.8%) had moderate stroke (NIHSS 5-15) on admission. The identified site of the cerebrovascular thrombi was within the M1 segment of the middle cerebral artery (41.9%, n=13). The stent retriever approach was performed in 19 of the subjects (61.2%). Upon discharge, only 17 (22.6%) had favorable functional outcomes (MRS 0-2) and 6 (19.3%) resulted in mortality.
Conclusion

Overall, endovascular thrombectomy is a promising treatment strategy for large vessel acute ischemic stroke in a developing country.
Part Two: Pharmacokinetic Evaluation of E-Liquid Flavors of Vuse Solo Electronic Nicotine Delivery System, An Unblinded, Parallel, Randomized Study To Assess Nicotine Uptake In Smokers
Authors: Hong Kyung Soo , DeLuca Patricia , Jin Tao , Jones Bobbette A. , Nelson Paul , Schmidt Eckhardt , Round Elaine
Published: December 2021

This paper reports the findings of a randomized nicotine pharmacokinetic (PK) study of a closed electronic nicotine delivery system (ENDS). The study evaluated four flavor variants of Vuse Solo ENDS where subjects used their randomized investigational product (IP) for 10 minutes ad libitum and blood samples were collected for PK assessments that included maximum plasma nicotine concentration (Cmax) and area under the nicotine concentration-vs-time curve up to 60 minutes (AUCnic0–60). Baseline-adjusted mean Cmax ranged from 6.53 to 8.21 ng/mL, and mean AUCnic0–60 ranged from 206.87 to 263.52 ng*min/mL for all ENDS IPs. Results for Cmax and AUCnic0-60 values were consistent among the ENDS IP flavor variants tested and results indicate that flavors did not affect nicotine uptake in human subjects.
Is It The Time That We Can Depend on Bioscore as a New Staging System in Non-Metastatic Breast Cancer to Predict the Disease-Free Survival?
Authors: Mohamed Rehab Farouk , Hameed Donia Hussein Abd El , Hassan Mohamed Alaa Eldeen
Published: December 2021

Purpose: Novel molecular characterization of breast cancer with cellular markers has allowed a new classification that offers prognostic value. This study investigates the prognostic value of the Bioscore among non-metastatic breast cancer patients with respect to disease free survival (DFS).Methods: This study included 317 patients with non-metastatic surgically treated breast cancer; they were identified in the period from January 2015 to December 2018 at Clinical Oncology Department of Assiut University Hospital. Many variables were used; pathologic stage (PS), T stage (T), nodal stage (N), grade (G), estrogen receptor (ER), progesterone receptors (PR), and human epidermal growth factor receptor (HER2) status. Univariate & two multivariate analyses were performed to identify which of these variables are associated with disease-free survival (DFS). Results: The only significant factors in the Univariate analysis were PS3, T2, T3, T4, N3, G2, G3, ER -ve, PR -ve, and HER2 –ve. The factors which were significant in the first multivariate analysis; PS3, G3, ER –ve, and in the second one were; T2, T4, N3, G3, and ER –ve. Two sets of models were built to determine the utility of combining variables. Models incorporating G and E status had the highest C-index (0.72) for T+N + G + ER in comparison with (0.69) for (PS+ G + ER) and the lowest AIC (953.01) for T + N + G + E and (966.9) for PS + G + E. Conclusions: This study confirms the prognostic significance of bioscore in non-metastatic breast cancer in concerning DFS.
Integrated analysis of ceRNA network in lung adenocarcinoma based on bioinformatics analysis
Authors: Wang Huixin , Li Qian , Hou Xiaowen , Shi Xinzhu , Feng Xu
Published: December 2021

Background

Increasing studies have revealed that long noncoding RNA (lncRNAs) can bind to microRNA (miRNAs) as competitive endogenous RNA (ceRNA), which can affect the expression of mRNAs. These lncRNA related ceRNAs theoretically play an important role in the occurrence and progress of cancer. However, the roles and functions of ceRNA network in lung adenocarcinoma (LUAD) are not completely clear.
Methods

1. The chip data were downloaded from the Gene Expression Omnibus (GEO). Different lncRNAs and mRNAs were analyzed by GEO2R, and then the target miRNAs and target mRNAs were predicted. The ceRNA network was constructed and subjected to enrichment analysis. 2. The lncRNA AFAP1-AS1 gene Knockout was constructed. The siRNA was constructed and transfected into LUAD cell A549 by cell transfection. The CCK8, Transwell, scratch assay and flow cytometry were used to gauging the ability of cell proliferation, invasion, migration, and apoptosis.
Results

In total, 6 lncRNAs and 494 mRNAs were identified as differentially expressed RNAs (DERNAs) in LUAD. A total of 6 DElncRNAs interacted with 22 DEmiRNAs and 22 DEmiRNAs interacted with 55 DEmRNAs were involved in the ceRNA network. These DEmRNAs were found to be related to cancer-related pathways, such as signaling pathways that regulate stem cell pluripotency, TGF-β signaling pathways, and protein digestion and absorption. Knockout of AFAP1-AS1 inhibits cell proliferation, invasion and migration. AFAP1-AS1 promotes apoptosis.
Conclusions

In this study, we constructed a lncRNA-miRNA-mRNA ceRNA network which may help further research on the mechanism of LUAD. In addition, we identified AFAP1-AS1 as an oncogenic lncRNA in LUAD.
Pulmonary Function, Physical Activity and Quality of Life in Chronic Obstructive Pulmonary Disease Patients: Secondary Data Analysis, Data from the Korea National Health and Nutrition Examination Survey 2015-2018
Authors: Lee Kyeongbong , Lee GyuChang
Published: December 2021

Background

COPD Patients may experience reduced physical activity and quality of life due to decreased pulmonary function. The purpose of this study is to analysis the level of pulmonary function, physical activity, and quality of life of COPD in South Korea.
Methods

This study collected the published data of the Korea National Health and Nutrition Examination Survey in 2015-2018. Out of a total of 31,648 COPD patients, the data of 121 patients were analyzed. For the pulmonary function, the data of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV6, and peak expiratory flow were collected. Physical activity was identified as frequency and duration of high/medium intensity, walking days, and strengthening exercise per week. For the quality of life (QoL), EQ-5D-3L were collected, and the frequency and index of the Korean version were collected.
Results

In the health-related characteristics, the prevalence of hypertension and asthma in COPD was relatively higher compared to other diseases. In pulmonary function, the predicted FEV1 and FEV1/FVC ratios were lower than age and weighted matched normal values. COPD showed to perform very low levels of high/medium physical activity and sitting time was confirmed to be more than 8 hours a day. In QoL, it was found that the highest reporting rate of some problems was the “pain and discomfort”.
Conclusion

It was confirmed that COPD showed lower predicted FEV1 and FEV1/FVC ratios than age and weight-matched normal pulmonary function. Also, they had lowered physical activities and longer sitting time per day.