bluuebunny/crossref_metadata_2025 huggingface dataset:
Persea americana Mill.: As a potent quorum sensing inhibitor of Pseudomonas aeruginosa PAO1 virulence
Authors: GÜRAĞAÇ DERELİ Fatma Tuğçe , ÖNEM Ebru , ÖZAYDIN Ayşe Gül , ARIN Evren , MUHAMMED Muhammed Tilahun
Published: February 2022

The emergence of bacteria resistant to conventional antibiotics and the inability of these antibiotics to treat bacterial biofilm-induced infections cause millions of deaths every year.
This situation has prompted scientists to develop alternative strategies to combat infectious diseases. Among these, researches on phytochemicals to reduce bacterial virulence in Pseudomonas aeruginosa have gained momentum in recent years. The main reasons behind this are the production of virulence factors and biofilm formation, all of which are under the control of quorum sensing (QS) system. Hence, inhibition of the QS pathways is an eligible strategy for the control of microbial pathogenesis.
For the first time in the present study, the methanolic seed extract of avocado was evaluated for its anti-QS activity against P. aeruginosa PAO1. The results of the experiments carried out proved that the extract has inhibitory activity on the regulation of virulence and biofilm formation. Phytochemical analysis resulted in the identification of epicatechin, catechin, chlorogenic acid, caffeic acid, quercetin, kaempferol, vanillin, ferulic acid in the extract. Then, the mechanism of action for the extract was investigated through molecular docking. Docking outcomes demonstrated that the major components, catechin, epicatechin, chlorogenic acid, could bind to the receptors of QS competitively. Hence, the mode of action for the extract might be through the inhibition of the QS. Considering the computational analysis results and the literature, it is thought that the anti-QS activity of the extract prepared from avocado seeds may be related to the synergistic effect of the phytochemicals it contains.
Devil's staircase of topological Peierls insulators and Peierls supersolids
Authors: Chanda Titas , Gonzalez-Cuadra Daniel , Lewenstein Maciej , Tagliacozzo Luca , Zakrzewski Jakub
Published: February 2022

We consider a mixture of ultracold bosonic atoms on a one-dimensional lattice described by the XXZ-Bose-Hubbard model, where the tunneling of one species depends on the spin state of a second deeply trapped species. We show how the inclusion of antiferromagnetic interactions among the spin degrees of freedom generates a Devil's staircase of symmetry-protected topological phases for a wide parameter regime via a bosonic analog of the Peierls mechanism in electron-phonon systems. These topological Peierls insulators are examples of symmetry-breaking topological phases, where long-range order due to spontaneous symmetry breaking coexists with topological properties such as fractionalized edge states. Moreover, we identify a region of supersolid phases that do not require long-range interactions. They appear instead due to a Peierls incommensurability mechanism, where competing orders modify the underlying crystalline structure of Peierls insulators, becoming superfluid. Our work show the possibilities that ultracold atomic systems offer to investigate strongly-correlated topological phenomena beyond those found in natural materials.
Rare and Different: Anomaly Scores from a combination of likelihood and out-of-distribution models to detect new physics at the LHC
Authors: Caron Sascha , Hendriks Luc , Verheyen Rob
Published: February 2022

We propose a new method to define anomaly scores and apply this to particle physics collider events. Anomalies can be either rare, meaning that these events are a minority in the normal dataset, or different, meaning they have values that are not inside the dataset. We quantify these two properties using an ensemble of One-Class Deep Support Vector Data Description models, which quantifies differentness, and an autoregressive flow model, which quantifies rareness. These two parameters are then combined into a single anomaly score using different combination algorithms. We train the models using a dataset containing only simulated collisions from the Standard Model of particle physics and test it using various hypothetical signals in four different channels and a secret dataset where the signals are unknown to us. The anomaly detection method described here has been evaluated in a summary paper where it performed very well compared to a large number of other methods.
The method is simple to implement and is applicable to other datasets in other fields as well.
Las aspiraciones educativas de la juventud fronteriza: el caso de Tijuana
Authors: Aguilar Barceló José G. , Osorio-Novela Germán , Aguilar Solís Guillermo A. , Mungaray-Moctezuma Ana B.
Published: February 2022

El presente artículo pretende identificar la influencia del contexto transfronterizo en las aspiraciones educativas de los estudiantes de educación media superior que radican en Tijuana, Baja California. Para este objetivo se estiman modelos de regresión de respuesta cualitativa que consideran variables de índole demográfica y socioeducativa, del ámbito migratorio, y relacionadas con el empeño, la motivación propia y el apoyo familiar. Se utilizan datos recopilados por el Mexican Migration Field Research Program. Se encontró que las expectativas son poco sensibles a las circunstancias migratorias y transfronterizas. En cambio, el nivel educativo de los padres, la dedicación al estudio, tener familiares cercanos estudiando y saber inglés son variables que sí parecen relevantes en la formación de las expectativas. Se concluye que los aspectos demográficos y socioeducativos, así como la dedicación propia y el apoyo familiar, determinan en mayor medida las aspiraciones de los jóvenes.
Increase in Cisplatin Resistance by MeCP2 in Human Gastric Cancer through the Activation of the AKT Pathway by Facilitating PDK-1 Transcription
Authors: Guo Bo , Cai Shuang , Li Wen , Guo Chen , Liu Yijie , Ma Xiaoping , Ma Hailin , Zhao Lingyu
Published: February 2022

Background:

Increasing evidence indicates that an imbalance in oncogenes is implicated in
cancer chemotherapy resistance. Methyl-CpG binding protein 2 (MeCP2), which acts as a major epigenetic
regulator of the expression of various genes, is involved in the carcinogenesis and progression
of gastric cancer. However, is it not known whether the role of MeCP2 is vital in acquired cisplatin
resistance in gastric cancer.

Objective:

This study aimed to determine whether inhibition of MeCP2 expression could sensitize
DDP-resistant GC cells to DDP and elucidate the underlying molecular mechanism.

Methods:

qRT-PCR and western blotting were used to evaluate MeCP2 expression in DDP-resistant
GC cells. Subsequently, cell viability, colony formation, cell cycle, apoptosis, and tumorigenicity assays
were performed to explore the in vitro and in vivo roles of MeCP2. Chromatin immunoprecipitation-
qPCR and luciferase reporter assays were used to identify whether 3-phosphoinositide-dependent
protein kinase 1 (PDK-1) was a direct target gene of MeCP2.

Results:

MeCP2 was upregulated in malignant DDP-resistant cells compared to non-DDP-resistant GC
cells or normal gastric epithelial cells. MeCP2 knockdown increased the sensitivity of DDP-resistant
GC cells to DDP, resulting in reduced cell growth, G0/G1 phase arrest, and increased apoptosis,
whereas MeCP2 overexpression attenuated DDP sensitivity of DDP-resistant GC cells. In addition,
MeCP2 knockdown enhanced DDP sensitivity in vivo. MeCP2 elevated PDK-1 expression by binding
to CpG sites in promoter regions, and inhibition of PDK-1 reversed the inductive effect of MeCP2
overexpression on DDP resistance in GC cells.

Conclusion:

These findings indicate that silencing of MeCP2 may potentiate DDP-induced cell death,
thereby providing a promising therapeutic strategy for GC.
The Journey from Porous Materials to Metal-organic Frameworks and
their Catalytic Applications: A Review
Authors: Samantaray Raghabendra , Sahu Rojalin , Panda Jagannath , Sahoo Tejaswini , Swain Jaykishon , Panda Prasanna Kumar , Tripathy Bankim Chandra
Published: February 2022

Metal-Organic Frameworks (MOFs), an inorganic-organic hybrid material, have been at the centre stage of material science for three decades. MOFs are synthesized by metal ions and organic linker precursors and have become very potential materials for different applications ranging from sensing, separation, catalytic behaviour to biomedical applications and drug delivery. owing to its structural flexibility, porosity and functionality. It is also very promising in heterogeneous catalysis for various industrial applications. These catalysts can be easily synthesized with extremely high surface areas, tunable pore sizes, and incorporation of catalytic centres via post synthetic modification (PSM) or exchange of their components as compared to traditional heterogeneous catalysts which is the preliminary requirement of a better catalyst. Here, in this review, we have sketched the history of MOFs, different synthesis procedures, and MOF- catalysed reactions, for instance, coupling reactions, condensation reactions, Friedel-Crafts reactions, oxidation, etc. Special attention is given to MOFs containing different catalytic centres including open metal sites, incorporation of catalytic centres through PSM, and bifunctional acid-base sites. Discussion on the important role of catalytic centres present in MOFs and reaction mechanisms has been outlined with examples.
Event Monitoring and Evaluation by Community Pharmacists in Japan: A Pilot Study on Fenofibrate and
Pemafibrate
Authors: Ooba Nobuhiro , Takahashi Masao , Nagamura Marina , Ushida Makoto , Kawakami Eiji , Kimura Masaomi , Sato Tsugumichi , Takahashi Yoshinori , Tokuyoshi Junichi , Hashiba Hajime , Kamei Miwako , Miyazaki Choichiro , Shimada Mitsuaki
Published: February 2022

Background:

The Japan Pharmaceutical Association has conducted drug event monitoring
to detect drug events related to pemafibrate. As there are a few studies on the safety of pemafibrate
in clinical settings, a pilot study evaluating the association between drug use and detected
events was performed in Japan.

Aim:

In this study, the association between detected events and the use of pemafibrate, utilizing
pharmacy records maintained by community pharmacists, was investigated. We identified the newuser
cohort using a test and active comparison drug and collected the baseline information. An active
comparison group comprising new users was used to assess the events.

Method:

A retrospective cohort study using questionnaires regarding baseline and event data was
conducted by community pharmacists belonging to the Japan Pharmaceutical Association. The incidence
of event and estimated hazard ratio were calculated using the Cox proportional hazards
model that was adjusted for confounding factors, such as age and sex.

Results:

A total of 1294 patients using pemafibrate and 508 patients using fenofibrate were identified
as new drug users. The most reported events involving suspected adverse reactions and add-on
drugs were increased blood pressure and lipid-lowering effects with pemafibrate use, and nasopharyngitis,
pruritus, dizziness, and lipid-lowering effects with fenofibrate use. No significant differences
were found in commonly occurring events, except that an add-on anti-hypertensive drug
has been used by pemafibrate users compared to fenofibrate users.

Conclusion:

This study conducted by pharmacists can facilitate the safety assessment of newly
marketed drugs, as few drug use investigations with a comparator are carried out by the Japanese
authority for pharmaceutical companies. However, further research is required.
The Persistence Time of SARS-CoV-2 RNA in Hospitalized COVID-19 Patients: A Prospective Study
Authors: Yavarian Jila , Javaherian Mohammad , Malekshahi Somayeh Shatizadeh , Ahmadinejad Zahra , Ghiasvand Fatemeh , Ahmadi Elaheh , Abbasian Ladan , Hasannezhad Malihe , Dabaghipour Narges , Shafiei-Jandaghi Nazanin-Zahra , Mokhtari-Azad Talat , Hajiabdolbaghi Mahboubeh
Published: February 2022

Background:

In late December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the causative agent of coronavirus disease 2019 (COVID-19), spread to almost all countries worldwide. The outbreak of this virus has been confirmed on 19th February, 2020, in Iran.

Objective:

The aim of this study was to investigate the time of viral RNA clearance in swab and serum samples of COVID-19 patients having received different medications. We also evaluated different factors that may affect viral RNA persistence in patients infected by SARS-CoV-2.

Methods:

In March 2020, twenty-one hospitalized COVID-19 patients participated in this prospective study. All patients received antiviral agents in their routine care. Throat swabs and blood samples were obtained from all patients in different intervals, including day 3 or 5, day 7, day 10, and finally, 14 days after the first positive real-time RT-PCR (rRT-PCT) test.

Result:

The median time from the symptom onset (SO) to the first negative rRT-PCR results for throat swabs and serum samples of COVID-19 patients was 18 and 14 days, respectively. These times were more significant in patients with lymphopenia, oxygen saturation ≤ 90%, and comorbidity.

Conclusion:

This preliminary study highlights that SASR-CoV-2 RNA was not detectable in the upper respiratory tract for longer than three weeks. In addition, SARS-CoV-2 may persist for a long period of time in the respiratory than in the serum samples. This study supports the idea that in limited resource settings, the patients should be tested earlier than three weeks for discharge management.
Brain Damage in the Preterm Infant: Clinical Aspects and Recent Progress
in the Prevention and Treatment
Authors: Yuan Tianming , Xie Yixuan , Yang Yue
Published: February 2022

Although the prevalence of brain injury and related neurodevelopmental disabilities resulting
from preterm birth are major public health concerns, there are no definite neuroprotective strategies
to prevent or reduce brain injury. The pattern of brain injury seen in preterm infants has evolved
into more subtle lesions that are still essential to diagnose regarding neurodevelopmental outcomes.
There is no specific effective method for the treatment of premature infant brain injury, and the focus
of clinical treatment is still on prevention. Prevention of this injury requires insight into the pathogenesis,
but many gaps exist in our understanding of how neonatal treatment procedures and medications
impact cerebral hemodynamics and preterm brain injury. Many studies provide evidence about the
prevention of premature infant brain injury, which is related to some drugs (such as erythropoietin,
melatonin, mesenchymal stem cells, etc.). However, there are still some controversies about the quality
of research and the effectiveness of therapy. This review aims to recapitulate the results of preclinical
studies and provide an update on the latest developments around etiological pathways, prevention,
and treatment.
Humeral Shaft Fractures: A Literature Review on Current Treatment Methods
Authors: Daoub Ahmed , Ferreira Pedro Miguel Oliveira , Cheruvu Srinivas , Walker Matthew , Gibson William , Orfanos Georgios , Singh Rohit
Published: February 2022

In this review, we aim to provide a concise yet comprehensive summation of the assessment and management of humeral shaft fractures. These are uncommon but prevalent enough that they are part of any trauma surgeon's scope of practice. They have historically been treated using non-operative methods, including braces and casts, supported by published excellent results in the rate of the bone union. However, recently published studies challenge these results and suggest the outcomes might be better with surgery, but the complications of an operation such as infection and nerve injury can not be overlooked. In summary, non-surgical treatment is still the gold standard in the treatment of these fractures, but the indications for surgical management are now clearer and include early signs of delayed union and patients who are unable to have a brace fitted or are uncompliant. It is likely that these new developments will start to change practice, and therefore the treatment of humeral shaft fractures should be a topic of interest of any clinician who deals with them.
In silico Investigation of Immunodominant Antigenic Regions, Helper T
Lymphocyte, and Cytotoxic T Lymphocyte Epitopes Credentials for
SARS-CoV-2 Vaccination
Authors: Selvaraj Manikandan , Loganathan Lakshmanan , Jayaraj John Marshal , Gopinath Krishnasamy , Rajendran Kannan , Pannipara Mehboobali , Al-Sehemi Abdullah G. , Muthusamy Karthikeyan
Published: February 2022

Background:

In recent days, COVID-19 cases are increasing globally at an alarming rate due to the COVID-19 second wave despite the mass vaccination programs. Search for the potential vaccine for SARS-CoV-2 is still under progress. The epitope-based vaccine is effective and is a cornerstone in vaccine development. The quick prediction of epitopes could be a proficient way to monitor vaccine development during a global health crisis.

Objective:

This study is designed to predict the potential epitopes with computational tools for vaccine development.

Methods:

NetCTLpan v. 1.1 and NetMHCIIpan v. 3.2 servers were used for T-cell epitope analysis. IEDB servers were employed for HLA and DRB1 peptide calculations. The epitope Immunogenicity, toxicity, physiochemical character, and other features are measured by immunogen evaluation. Furthermore, the top-ranked immunogenic epitopes were computationally validated by molecular docking analysis. The epitopes are docked to Toll-like receptors (TLRs), which is helpful to generate an immune response against SARS-CoV-2.

Results:

Overall, six HTL and CTL epitopes were predicted (IDGYFKIYSKH, HPLSHFVNLDNL, RIGNNYKLNT, and WTAGAAAYYVG, MACLVGLMWLS, FRLKGGAPIKGVT), which had good immunogenicity scores, and stable interaction with Toll-like receptor (TLR). Therefore, these epitopes can bind with HLA and DRB1 molecules, respectively.

Conclusion:

The computationally predicted antigenic regions might be considered for epitope-based vaccine against SARS-CoV-2 after in vitro
Transungual Drug Delivery System for the Topical Treatment of Onychomycosis:
A Review
Authors: Giri Yashwant , Behera Amulyaratna , Mohanty Biswaranjan , Pattnaik Gurudutta , Habibullah S.K.
Published: February 2022

Onychomycosis is an infection caused by a fungus that causes discoloration and thicken-ing of the nail layer, and it is the most common nail infection in the world. Trichophyton rubrum and Trichophyton mentagrophytes var. interdigital is the most common anthropophilic dermato-phytes that trigger it. Onychomycosis is caused by yeasts such as Candida albicans and Candida parapsilosis, as well as moulds such as Aspergillus spp. Treatment is determined by the type of nail invasion, the fungus genus, and the number of nails affected. Approaches towards conventional methods showed certain drawbacks, which emphasizes the need for alternate approaches to produce better therapeutic efficacy of a product. The present review focused on reporting an updated classi-fication of Onchyomycosis, causative organisms, factors influencing drug permeation, novel treat-ment strategies for Onychomycosis, and drug permeation enhancement methods.
Combination of Biocatalysis and Sonochemistry in the Ethyl Oleate Production
Authors: de Almeida Natália Alves , Rosset Isac George
Published: February 2022

Objectives:

Fatty acid alkyl esters (FAAEs) are a family of natural neutral lipids and can be produced cleanly and sustainably by esterification of free fatty acids (FFAs) with short chain alcohol using enzymatic catalysts. In this study, the use of lipases was evaluated in enzymatic esterification of oleic acid with ethanol using the combination of biocatalysis and sonochemistry (ultrasound) in the absence of co-solvents.

Methods:

Reaction parameters, such as type of lipase, amount of enzyme, reaction time, alcohol hydration level and enzyme turnover were evaluated for the enzymatic synthesis of ethyl oleate.

Results:

C. antarctica lipase provided yields above 95% in less than 10 h with 10% (w/w) of lipase. The use of hydrous ethanol (5% of water) showed a slight drop in yield but remained above 90% of ethyl oleate production. C. antarctica lipase showed no loss efficiency even after 10 reaction cycles.

Conclusion:

The combination of biocatalysis and ultrasound radiation provided a high yield, showing that the combination of these tools may be a good choice for the enzymatic synthesis of ethyl oleate.
Optimized Algebraic Algorithm for Ambiguity Resolution and DOA Computation
in Baseline Interferometer
Authors: Suram Sudha Rani , Prasad Niranjan , Gottapu Sasibhushana Rao
Published: February 2022

Background:

Interferometer is the most preferred technique for high accuracy direction finding. For broadband direction finding (DF) applications, multiple antennas forming a number of baselines are used to achieve better accuracy in measuring the direction of arrival (DOA). Ambiguity resolution in multi-element interferometers is a crucial algorithm for the computation of DOA.

Objective:

This paper introduces a fast, algebraic Common Minimum Modulo Search (CMMS) algo-rithm for ambiguity resolution and DOA computation. LabVIEW-based tool for Monte Carlo simula-tion of the algorithm over various parameters is described.

Method:

The CMMS is a computationally efficient algorithm, where the longest baseline phase difference is used for accuracy, and the phase difference data from all other baselines are used for resolving the ambiguities in the longest baseline. A hybrid approach using correlation and minimum algebraic search is used to determine the best fit set of ambiguities to the measured phase difference data.

Results:

Case studies have been presented in the literature and the performance of the CMMS algo-rithm was validated against established algorithms. This paper discusses the FPGA implementation as well as its simulation results. Analysis is performed on the 6-18 GHz frequency band. Moreover, the sources of errors and resulting limitations regarding the applicability of the algorithm are also discussed.

Conclusion:

Simulation results establish the algorithm's effectiveness in ambiguity resolution and applicability to diverse array configurations. The short nine-clock cycle processing latency in FPGA is demonstrated by the simulation results.
COVİD-19 Korkusunun Annenin Doğumu Algılaması ve Doğum Sonu Anksiyeteye Etkisi
Authors: ÖZŞAHİN Zeliha , ERDEM Neslihan , AKSAKAL Zeliha Gülsüm , FİLOĞLU Nilay
Published: February 2022

Giriş: COVID-19 salgınının, stres etkilerine karşı savunmasız olan gruplar arasında gebe kadınlar ve yakın zamanda doğum yapmış kadınlar bulunmaktadır. İzolasyon sürecinde kadınların doğum sonrası bakımla ilgili beklentilerin azalmasına ve doğumun çeşitli yönlerine ilişkin anksiyeteye neden olduğu gösterilmiştir. Bu nedenle bu çalışmada COVID-19 korkusunun annenin doğumu algılaması ve doğum sonu anksiyeteye etkisini belirlemek amaçlanmaktadır. Yöntem: Tanımlayıcı-kesitsel nitelikte yapılan araştırmanın evrenini lohusalar oluşturmuştur. Power analizi yapıldığında 0.25 etki büyüklüğünde, 0.05 yanılma payında, 0.95 güven düzeyinde, 0.95 evreni temsil gücüyle örneklem büyüklüğü en az 202 lohusa olarak belirlendi. Araştırma 255 lohusa ile tamamlandı. Veriler, “Kişisel Tanıtım Formu”, COVID 19 Korkusu Ölçeği’’, ‘‘Annenin Doğumu Algılaması Ölçeği (ADAÖ)’’, ‘‘Durumluk Kaygı Ölçeği (DKÖ)’’ ile toplanmıştır. İstatistiksel değerlendirmede tanımlayıcı istatistiklerin yanı sıra, Cronbach’s alfa lineer regresyon analizi kullanılmıştır. Bulgular: Araştırmaya katılan annelerin almış oldukları puanların ortalaması sırası ile 18.98±13.04 (COVID-19 korku ölçeği), 73.64±13.04 (ADAÖ) ve 36.02±9.38 (DKÖ) şeklindedir. Yapılan analiz sonucunda COVID -19 korkusunun annenin doğumu algılaması ve alt boyutlarını negatif yönde etkilediği fakat bu etkinin istatistiksel olarak anlamlı olmadığı, doğum sonu anksiyeteyi pozitif yönde anlamlı bir şekilde yordadığı ve kurulan modelin istatistiksel olarak anlamlı olduğu belirlenmiştir. Sonuç: Annenin doğumu algılamasının COVID- 19 korkusundan etkilenmediği, daha yüksek düzeydeki COVID- 19 korkusunun daha yüksek doğum sonu anksiyeteye eşlik ettiği söylenebilir.
Peran Penyuluh terhadap Pemberdayaan Masyarakat dalam Pengelolaan Daerah Aliran Sungai
Authors:   Balai Penelitian dan Pengembangan Teknologi Pengelolaan DAS, Indrawati Dewi , Yuliantoro Dody
Published: February 2022

Pemberdayaan masyarakat dalam dalam pengelolaan DAS adalah sesuatu yang mutlak diperlukan terutama untuk DAS yang sebagian besar wilayahnya merupakan lahan milik seperti Sub DAS Keduang. Oleh karena itu, peran penyuluh sebagai ujung tombak dalam menggerakkan pemberdayaan masyarakat harus semakin mendapat perhatian. Penelitian ini bertujuan untuk mengetahui peran penyuluh terhadap pemberdayaan masyarakat dalam pengelolaan DAS. Penelitian dilakukan pada tiga DAS mikro di Sub DAS Keduang (DAS Mikro Naruan, Jlegong dan Pohbener). Penelitian bersifat deskriptif dengan menggunakan pendekatan kuantitatif dan kualitatif. Pengumpulan data dilakukan dengan teknik wawancara menggunakan kuesioner, wawancara mendalam (in-depth interview), dan observasi. Data dikumpulkan dari anggota dan pengurus kelompok tani, perangkat desa, dan penyuluh (kehutanan dan pertanian). Hasil penelitian sebagai berikut: 1) Peran penyuluh sebagai pendidik cukup baik dan masuk kategori sedang sampai tinggi; 2) Frekuensi penyuluhan masih kurang memadai karena tidak seimbangnya jumlah penyuluh dan kelompok tani; 3) Peran penyuluh sebagai fasilitator dan mediator masih masuk kategori sangat rendah sampai rendah; 4) Perlu upaya untuk meningkatkan kapasitas penyuluh dalam teknik pemberdayaan masyarakat.
Pengaruh Asimetris Nilai Tukar Rupiah terhadap Nilai Ekspor Sektor Pertanian Indonesia
Authors:   Ilmu Ekonomi Pertanian, Sekolah Pascasarjana, IPB University, Fadillah Tamalia , Hakim Dedi , Rindayati Wiwiek
Published: February 2022

Indonesia menganut sistem nilai tukar mengambang bebas, kelemahan sistem ini yaitu mudahnya nilai tukar mengalami apresiasi dan depresiasi. Nilai tukar memiliki pengaruh terhadap perekonomian, terutama pada pertumbuhan ekspor. Sektor yang mengalami defisit atau melemah akibat pergerakan nilai tukar rupiah adalah sektor pertanian. Studi empiris menganalisis pengaruh nilai tukar terhadap ekspor telah umum dilakukan, namun peneliti tidak mempertimbangkan adanya efek asimetris, sedangkan mungkin saja terdapat efek asimetris. Tujuan penelitian adalah menganalisis pengaruh asimetris nilai tukar rupiah terhadap nilai ekspor sektor pertanian Indonesia dan menganalisis perubahan nilai ekspor sektor pertanian Indonesia lebih respon dipengaruhi ketika rupiah depresiasi atau apresiasi. Jenis data penelitian adalah data sekunder dalam deret waktu bulanan dari Januari 2006 (2006M1) sampai Januari 2020 (2020M1). Model penelitian adalah model Nonlinier Autoregressive Distributed Lag (NARDL). Hasil penelitian adalah terdapat pengaruh asimetris nilai tukar rupiah terhadap nilai ekspor sektor pertanian Indonesia dan perubahan nilai ekspor pertanian Indonesia lebih responsif dipengaruhi ketika rupiah apresiasi dibanding dengan ketika rupiah depresiasi
Pengaruh Marketing Mix 7P terhadap Kepuasan dan Loyalitas Konsumen Produk Olahan Kopi Espresso di Kota Semarang
Authors:   Program Studi Agribisnis, Departemen Pertanian, Fakultas Peternakan dan Pertanian, Universitas Diponegoro (Email: sylviagaradhita@gmail, Dhita Sylvia , Mukson Mukson , Setiadi Agus
Published: February 2022

Bauran pemasaran sebagai salah satu strategi pemasaran digunakan untuk merumuskan rancangan strategi pemasaran yang taktis dan efektif. Penerapan bauran pemasaran atau marketing mix 7P yang terdiri dari product, price, place, promotion, people, process dan physical evidence perlu dilakukan untuk memperbaiki dan mempertahankan sasaran pasar serta dapat dijadikan bahan evaluasi dalam bersaing dengan kompetitor untuk meningkatkan penjualan produk dan berorientasi kepada kepuasan dan koyalitas konsumen. Penelitian ini bertujuan untuk menganalisis pengaruh marketing mix 7P terhadap kepuasan dan loyalitas konsumen, dan menganalisis variabel marketing mix 7P yang berpengaruh paling dominan terhadap kepuasan dan loyalitas konsumen produk olahan kopi espresso di Kota Semarang. Metode penelitian yang digunakan adalah survei. Pengambilan sampel dilakukan dengan metode accidental sampling dengan jumlah responden sebanyak 100 orang. Metode analisis data menggunakan path analyis atau analisi jalur. dan pengolahan data dilakukan dengan alat bantu SPSS Statistics 22. Hasil penelitian menunjukkan bahwa nilai t tabel = 1,98638 sehingga product, promotion, dan kepuasan konsumen berpengaruh secara siginifikan, sedangkan variabel lainnya tidak berpengaruh secara signifikan terhadap loyalitas konsumen. Nilai uji f hitung 8,669 > f tabel 2,04 sehingga variabel independen berpengaruh positif dan signifikan terhadap variabel dependen. Variabel product berpengaruh sangat nyata terhadap kepuasan dan loyalitas konsumen. Besar pengaruh product terhadap loyalitas konsumen yaitu 28,3%, lalu pengaruh secara tidak langsung sebesar 2,97% dan pengaruh total yang diberikan adalah sebesar 31,27%. 8. Kepuasan konsumen berpengaruh positif secara langsung terhadap loyalitas konsumen. Besarnya pengaruh kepuasan terhadap loyalitas konsumen yaitu 23,6% dan besarnya pengaruh secara gabungan yaitu 43,2%.
Pemberdayaan dan Penanganan Pola Konsumsi Pangan Masyarakat di Wilayah Kota Batu
Authors:   Fakultas Pertanian, Universitas Brawijaya Malang, Sugiyanto Sugiyanto , Nurhadi Iwan , Pintakami Lintar
Published: February 2022

Indonesia adalah Negara dengan populasi penduduk yang nomor 4 terbanyak di dunia, dan semakin bertambah dari tahun ketahun. Bertambahnya jumlah penduduk tentunya akan diikuti dengan bertambahnya permintaan akan bahan pangan. Fenomena tersebut menyebabkan pemerintah harus berupaya agar kebutuhan akan bahan pangan terus tercukupi yang berasal dari hasil produksi dalam negeri maupun dari luar negeri. Ketahanan pangan berjalan lurus dari status gizi suatu Negara. Status gizi yang baik dapat terwujud jika pola konsumsi pangan pada tingkat rumah tangga dan individu juga baik. Pola konsumsi yang baik adalah pola konsumsi yang diasup secara beragam, berimbang, berigizi dan aman. Konsumsi yang beragam adalah bahan pangan yang dikonsumsi tersebut harus beragam dan tidak hanya bergantung pada satu jenis bahan pangan saja. Konsumsi yang berimbang adalah sumbangan setiap jenis sumber pangan harus tercukupi tanpa salah satunya mengalami kelebihan ataupun kekurangan. Bahan pangan yang aman adalah kondisi bahan pangan yang terhindar dari zat-zat berbahaya jika dikonsumsi. Berdasarkan keterangan tersebut diketahui pola konsumsi Masyarakat di Wilayah Kota Batu masih didominasi oleh tingginya konsumsi dari sumber pangan karbohidrat, terutama beras. Oleh sebab itu diperlukan perubahan dalam pola konsumsi pangan dengan meningkatkan pendidikan, pengetahuan gizi, dan kesejahteraan masyarakat, sehingga status gizinya tercukupi. Penelitian ini bertujuan memetakan dan menganalisis Penanganan Pola Konsumsi Pangan Masyarakat di Wilayah Kota Batu, penentuan responden dengan menggunakan teknik Simple Random Sampling. Pengumpulan data primer melalui kuisioner dan wawancara, sedangkan data sekunder bersumber dari data BPS dan Instansi terkait.
Analisis Pengaruh Experiential Marketing terhadap Kepuasan Pelanggan di 372 Kopi Setiabudhi Kota Bandung
Authors:   Departemen Teknologi Industri Pertanian, Universitas Padjadjaran, Hadiputri Syaqila , Pujianto Totok , Purnomo Dwi
Published: February 2022

Penelitian ini dilakukan untuk menganalisis pengaruh experiential marketing dengan 5 aspek sense (panca indera), feel (perasaan), think (cara berpikir), act (kebiasaan), relate (pertalian) terhadap kepuasan pelanggan di 372 Kopi Setiabudhi yang dianggap sangat penting sebagai contoh dalam penerapan konsep experiential marketing. 372 kopi Setiabudhi melakukan pendekatan pemasaran experiential marketing dengan banyak menyentuh sisi psikologi pelanggan. Penelitian ini merupakan jenis penelitian deskriptif verifikatif dengan responden sebanyak 100 orang. Data dikumpulkan dengan metode observasi yang dibantu oleh alat business model canvas, emphaty map, customer journey dan kuesioner, yang selanjutnya dianalisis menggunakan analisis regresi berganda menggunakan SPSS for windows yang meliputi pengujian hipotesis. Variabel experiential marketing berpengaruh secara signifikan terhadap aspek kepuasan pelanggan di 372 Kopi Setiabudhi dengan nilai F hitung sebesar 31.523 dengan Sig. 000. Nilai sig 0,000 < 0,05 dan memiliki koefisien positif.
Analisis Produksi dan Skala Ekonomi Usahatani Sawi Putih (Brassica pekinensis) di Kecamatan Gisting Kabupaten Tanggamus
Authors:   Politeknik Negeri Lampung, Ameliana Nadia , Sutarni Sutarni , Berliana Dayang
Published: February 2022

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berpengaruh dalam produksi sawi putih dan menganalisis ekonomi skala usaha sawi putih. Metode penelitian yang digunakan yaitu metode survey. Penelitian ini di lakukan di Kecamatan Gisting, Kabupaten Tanggamus dengan jumlah responden sebanyak 52 petani. Analisis yang digunakan adalah Fungsi Produksi Cobb-Douglas. Hasil analisis menunjukkan bahwa faktor-faktor yang berpengaruh dalam produksi sawi putih pada taraf nyata 10% yaitu luas lahan (X1), pupuk tunggal urea (X3), pupuk majemuk NPK (X4), pestisida (X5), dan Dummy pupuk kandang (D), Sedangkan faktor yang tidak berpengaruh nyata dalam produksi sawi putih yaitu benih (X2) dan tenaga kerja (X6). Skala ekonomi atau return to scale menunjukkan nilai 1,076, pada posisi ini skala ekonomi usahatani sawi putih berada pada kondisi increasing returns to scale.
Preferensi Konsumsi Daging Sapi oleh Masyarakat Tionghoa di Kota Pontianak
Authors:   https://jepa.ub.ac.id/index.php/jepa/article/view/945#articleAbstract, Setyadi Anselmus , Dolorosa Eva , Aritonang Marisi
Published: February 2022

Penelitian ini bertujuan untuk mengetahui atribut yang berpengaruh terhadap preferensi serta tingkat preferensi konsumsi daging sapi oleh masyarakat Tionghoa di Kota Pontianak. Penelitian menggunakan metoe survei dengan jumlah sampel ditentukan secara purposive sebanyak 100 responden. Semua responden adalah masyarakat Tionghoa di wilayah Kota Pontianak yang mengkonsumsi daging sapi. Analisis yang digunakan adalah analisis Konjoin. Hasil analisis konjoin menunjukan bahwa masyarakat Tionghoa menyukai daging sapi dengan ciri daging berwarna merah terang, bertekstur empuk, lemak sedikit dan daging tanpa lemak, ukuran pembelian < 1 Kg dan 1-2 Kg, potongan kelas 1 dan potongan kelas 2, aroma daging segar dan jenis daging yang baru disembelih. Atribut yang paling penting dilihat dari nilai importance values secara berturut-turut adalah aroma (19,93%), warna (18,59%), lemak (17,81%), tekstur (13,18%), jenis daging (13,01%), ukuran pembelian (8.96%) dan potongan (8,51%). Tingkat preferensi konsumsi oleh masyarakat Tionghoa terhadap daging sapi yang paling disukai terdapat pada profil 37 dengan kombinasi warna merah terang, daging empuk, daging tanpa lemak, ukuran pembelian 1-2 Kg, potongan kelas II, aroma daging segar, dan tipe daging yang segar atau baru disembelih.
Pengaruh Social Distancing Selama Covid-19 terhadap Perilaku Pembelian Sayuran pada Ibu Rumah Tangga di Kota Bandung
Authors:   Universitas Muhammadiyah Bandung, Ramayani Ira , Hanifawati Tri , Sutandi Agus
Published: February 2022

Social distancing merupakan kebijakan pemerintah dalam upaya untuk mengurangi penyebaran Covid-19, dimana masyarakat dihimbau untuk melakukan segala aktifitas di rumah saja. Namun demikian, selama kebijakan social distancing masyarakat tetap harus memenuhi berbagai kebutuhan pokok setiap harinya, khususnya sayuran. Penelitian ini bertujuan untuk mengetahui pengaruh social distancing selama pandemi Covid-19 terhadap perilaku pembelian sayuran pada Ibu Rumah Tangga di Kota Bandung dan untuk mengetahui perbedaan perilaku sebelum dan selama pandemi. Penelitian ini menggunakan metode kuantitatif, dimana data primer dikumpulkan melalui survey online terhadap 102 responden yang dihitung berdasarkan rumus Slovin pada taraf kesalahan 10%. Adapun responden merupakan Ibu Rumah Tangga yang berdomisili di Kota Bandung yang diambil secara acak. Data dianalisis menggunakan analisis regresi linier dan uji paired sample t-test. Hasil penelitian menunjukkan bahwa variabel social distancing berpengaruh signifikan terhadap keputusan pembelian dan terdapat perbedaan signifikan pada perilaku pembelian sayuran antara sebelum dan selama pandemi pada beberapa aspek, yakni tingkat konsumsi, intensitas konsumsi, cara pembayaran, saluran pembelian, dan cara belanja.
Strategi E-Commerce pada Agribisnis Ternak Kambing Perah Menggunakan Importance Performance Analysis di Kecamatan Wonosari Kabupaten Malang
Authors:   Mahasiswa Pascasarjana, Fakultas Peternakan Universitas Brawijaya, Nussy Evanglist , Nugroho Bambang , Utami Hari
Published: February 2022

Penelitian ini bertujuan untuk: (1) mengetahui penerapan e-commerce pada agribisnis peternakan kambing perah; (2) mengetahui peran e-commerce terhadap permintaan agribisnis kambing perah; (3) merumuskan strategi penerapan e-commerce pada agribisnis kambing perah dalam menghadapi era revolusi 4.0. Penelitian ini dilaksanakan pada bulan Maret 2020 sampai April 2020 di Kecamatan Wonosari Kabupaten Malang. Metode pengambilan sampel dalam penelitian ini adalah teknik purposive sampling berdasarkan data primer di lapangan dan data sekunder. Responden terdiri dari 60 peternak, 1 petugas lapangan Dinas Peternakan dan Kesehatan Hewan Kabupaten Malang. Penelitian ini menggunakan teknik importance performance analysis. Kesimpulan dari penelitian ini terdiri dari lima strategi implementasi e-commerce dengan menggunakan Importance performance analysis meliputi: (i) Prioritas utama yaitu dengan meningkatkan sarana dan prasarana untuk membantu perluasan jaringan internet di Kabupaten Wonosari. (ii) Strategi kedua untuk implementasi e-commerce prioritas tinggi, yaitu dengan mempertahankan penggunaan e-commerce yang masih menggunakan media sosial dan platform komunikasi, dan meningkatkan manfaat e-commerce (iii) strategi ketiga untuk prioritas yang tergolong rendah yaitu dengan meningkatkan pengetahuan tentang penggunaan e-commerce yang sesuai dengan kebutuhan bisnis kambing perah yang semakin berkembang di era 4.0 sehingga peternak akan lebih memahami pentingnya digitalisasi bisnis agar lebih efektif dan efisien. (iv) Strategi keempat penerapan e-commerce yang dinilai berlebihan yaitu lebih update dan membiasakan diri dengan cara penggunaan m-commerce dan akses e-commerce sehingga breeder lebih mengetahui cara mengakses dan membuka peluang ekspor. di era revolusi industri 4.0.
Analisis Biaya Kualitas pada Produk Keripik Apel “Ramayana” dengan Menggunakan Metode Activity Based Costing
Authors:   Program Studi Agribisnis Fakultas Pertanian Universitas Brawijaya, Ningtias Fatma , Priminingtyas Dina , Rayesa Neza
Published: February 2022

Kualitas merupakan salah satu faktor penting pada sebuah produk. Ramayana Agro Mandiri menjadi salah satu agroindustri yang memperhatikan kualias. Guna menjaga kualitas agroindustri melakukan kegiatan pengendalian. Biaya untuk kegiatan pengendalian tersebut belum diperhitungkan oleh agroindustri. Oleh karena itu penelitian dilakukan dengan tujuan untuk mengidentifikasi biaya kualitas yang ada serta mengetahui peranan biaya kualitas pada biaya produksi. Metode yang digunakan untuk menghitung biaya kualitas adalah metode activity based costing dengan pendekatan penelitian kuantitatif. Hasil penelitian menunjukkan bahwa Setiap kategori biaya kualitas memiliki nilai Rp384,844,- untuk biaya pencegahan, Rp906.250,- untuk biaya penilaian, dan Rp435.000,- untuk biaya kegagalan internal. Persentase biaya kualitas terhadap penjualan bernilai sebesar 2,35%. Persentase biaya kualitas real terhadap biaya produksi adalah sebesar 4,12%, sedangkan persentase biaya kualitas taksiran adalah sebesar 4,03%. Nilai tersebut menggambarkan bahwa terjadi penurunan yang artinya biaya kualitas memiliki peranan dalam meningkatkan efisiensi biaya produksi.
Analisis Ketimpangan Distribusi Pendapatan Petani Jambu Mete (Studi Kasus di Desa Mauta, Kabupaten Alor)
Authors:   Program Studi Agribisnis,Fakultas Pertanian dan Perikanan, Universitas Tribuana Kalabahi, Molebila Didiana , Latuan Emirensiana , Lutang Nopi
Published: February 2022

Petani jambu mete di Desa Mauta, Kecamatan Pantar Tengah, kabupaten Alor Propinsi Nusa tenggara Timur mengandalkan perkebunan jambu mete sebagai sumber pendapatan rumah tangga dan masih tetap menjalankan model pemasaran tradisional dengan menjual langsung ke pedagang pengumpul. Setiap pedagang pengumpul memiliki kisaran harga penjualan yang berbeda-beda. Meskipun total produksi terus meningkat, tetapi perbedaan harga pemasaran dapat menyebabkan terjadi perbedaan pendapatan. Sehingga, hal ini mengakibatkan kemungkinan terjadi ketimpangan distribusi pendapatan. Oleh karena itu dilakukan penelitian untuk mengetahui besaran pendapatan dan ketimpangan distribusi pendapatan petani jambu mete di Desa Mauta. Penelitian ini dilakukan dengan metode survei dan wawancara langsung pada 85 petani responden dengan menggunakan kuisioner. Hasil penelitian menunjukkan bahwa besaran pendapatan petani jambu mete mencapai Rp. 499.773.000 dan rata-rata pendapatan tiap petani sebesar Rp. 5.879.682. Diperoleh juga hasil bahwa tidak terjadi ketimpangan distribusi pendapatan yang berarti pada pendapatan petani jambu mete di desa Mauta. Hal ini ditunjukkan dengan nilai koefisien gini sebesar 0,370 dan berdasarkan indikator Koefisien Gini < 0,4 maka termasuk dalam tingkat ketimpangan rendah berdasarkan Bank Dunia bahwa terdapat 40% tanggga tani berpendapatan rendah menerima > 17% (>Rp.84.961.410) dari total pendapatan sebesar Rp. 499.773.000
Penyuluhan Pertanian Berbasis Teknologi Informasi di Kabupaten Bone Bolango
Authors:   Jurusan Agribisnis, Fakultas Pertanian, Universitas Negeri Gorontalo, Moonti Agustinus , Bempah Irwan , Saleh Yanti , Adam Echan
Published: February 2022

Penyuluhan pertanian menjadi kegiatan utama yang selalu berperan dalam mengedukasi petani. Di tengah kondisi pandemik Covid-19, kegiatan penyuluhan yang biasanya dilaksanakan secara tatap muka, kini dapat dilaksanakan secara virtual (online) berbasis teknologi informasi. Tujuan dari penelitian ini untuk menganalisis efektifitas pelaksanaan penyuluhan pertanian berbasis teknologi informasi terhadap petani pada situasi social distancing di Kabupaten Bone Bolango. Penelitian ini menggunakan model pendekatan ekperimental dengan melakukan uji coba penyuluhan berbasis teknologi informasi terhadap petani di Kabupaten Bone Bolango. Sampel dipilih dengan tehnik purposive sampling, dengan penentuan besaran sampel sebesar 25% atau 35 orang petani. Tehnik analisis data menggunakan metode EPIC model, dengan pendekatan komunikasi mencakup empat dimensi kritis yaitu Empathy, Persuation, Impact dan Communication (EPIC). Tingkat efektivitas media penyuluhan yang menggunakan EPIC model ditentukan dengan Likerts Summated Rating Scale (LSRS). Hasil penelitian menunjukkan bahwa model penyuluhan online baik menggunakan konten materi dalam bentuk teks maupun video secara umum memperoleh kategori yang kurang efektif untuk membentuk pengetahuan dan pemahaman petani di Kabupaten Bone Bolango. Namun, secara parsial konten penyuluhan berbasis teknologi informasi yang ditampilkan dalam bentuk video tergolong kategori efektif. Upaya peningkatan penguasaan dan pemanfaatan teknologi informasi perlu dilakukan petani dalam merespon serta mendukung pelaksanaan penyuluhan pertanian berbasis teknologi informasi di tengah kondisi pandemik saat ini.
Pengaruh Bauran Pemasaran Produk Getas Wah-You terhadap Keputusan Pembelian Konsumen di Kota Pangkalpinang
Authors:   Universitas Bangka Belitung, Dina Dina , Evahelda Evahelda , Purwasih Rati
Published: February 2022

Kota pangkalpinang memiliki potensi di sector perikanan, dimana hasil dari sektor perikanan tersebut memunculkan sebuah kegiatan usaha pengolahan hasil dari ikan. Salah satu usaha yang mengolah hasil perikanan yaitu adalah industri dengan skala rumah tangga yaitu industri getas Wah-you. Adanya banyak industri di kota pangkalpinang menyebabkan industri getas Wah-you untuk biasa bersain dengan produk yang ditawarkan oleh industri sejenis. Sehingga dengan Penelitian ini peneliti bertujuan untuk menganalisis faktor-faktor yang berpengaruh dalam bauran pemasaran terhadap keputusan pembelian akan produk getas Wah-you. Waktu dan tempat penelitian ini dilaksanakan mulai dari bulan Februari hingga bulan Agustus 2020 di Industri rumah tangga getas Wah-you. Metode penelitian yang digunakan dalam penelitian ini adalah metode studi kasus, jenis data yang digunakan yaitu data primer, dengan sedangkan metode penarikan contoh menggunakan metode accidental dengan jumlah respondense banyak 30 orang. Metode analisis data menggunakan analisis regresi linear berganda. Hasil penelitian menunjukan bahwa faktor yang berpengaruh dalam bauran pemasaran terhadap keputusan pembelian akan getas Wahyo yaitu variabel price. Sedangkan variabel product, promotion, dan place tidak berpengaruh nyata terhadap keputusan pembelian konsumen akan getas Wah-you.
Cultural and Religious Meanings of Number One Thousand in the Qur’an
Authors:   Allame Tabatabai University, Sharifi Ali , Besharati Zahra , Abdullahi Musa
Published: February 2022

The article provides a culturological and religious studies analysis of number 1000 (one thousand) and its non-numeric connotations. The authors consider numbers as iconic symbols that are used by people in everyday life, as well as in different religions and cultures. A separate research interest is the mention of numbers in the verses of the Qur’an and the way they are in-terpreted by commentators of the Holy Scripture, for example, numbers seven, one hundred, two hundred and others. The research is aimed at analyzing the cultural and religious meanings of number one thousand (1,000) and its multiples mentioned in the Qur’an. Number one thou-sand is mentioned eight times in the Qur’an. For example, in its first mention in Surah 2 ayat 96, it is suggested that the Quranic number “a thousand” (a thousand years) symbolizes the longest life, since number 1,000 in Arabic is the last range of numbers in terms of a numerical unit. There are separate Quranic mentions of numbers symbolizing something very long or expressing the power of believers. Thus, in its different connotations, number one thousand in the Qur'an contains a different semantic and symbolic load: large and centralized power, longevity, long-term survival, multiplicity, integrity, etc. The authors consider the non-numerical (symbolic) meaning of number one thousand and its multiples, as they are used in the Holy Scriptures of Muslims, from the perspective of various religions and cultures.
“Deradicalization of Political Islam as an Urgent Task of Modern Civilizational Devel-opment: Global and Russian Practices”. Roundtable discussion at the Institute of Africa of the Russian Academy of Sciences
Authors:   Senior Research Fellow, Institute for African Studies, Russian Academy of Sciences, Nefliasheva Naima , Karpacheva Olga
Published: February 2022

“Deradicalization of political Islam as an urgent task of modern civilizational development: global and Russian practices” roundtable discussion was based on theoretical and field studies devoted to the analysis of programs of deradicalization of Islamism in different countries. The urgency of this issue is due to the threat of an increase in radical sentiments in the world, as well as the obvious futility of practicing only a coercive approach in combating the threats of violent extremism motivated by religion. In this regard, finding a common strategy for deradicalization of former members of extremist groups is a pressing matter. The presented reports raise prob-lems related to the lack of elaboration of deradicalization programs and the need to adapt them to the changing socio-economic and political conditions. The question of critical re-evaluation of deradicalization programs for Russia and their implementation was discussed. The need to de-velop a common terminological apparatus and the importance of a versatile approach to the is-sue of deradicalization was also noted.