bluuebunny/crossref_metadata_2025 huggingface dataset:
Getting the whole story: Integrating patient complaints and staff reports of unsafe care
Authors: Van Dael Jackie , Gillespie Alex , Reader Tom , Smalley Katelyn , Papadimitriou Dimitri , Glampson Ben , Marshall Daniel , Mayer Erik
Published: July 2021

Objective

It is increasingly recognized that patient safety requires heterogeneous insights from a range of stakeholders, yet incident reporting systems in health care still primarily rely on staff perspectives. This paper examines the potential of combining insights from patient complaints and staff incident reports for a more comprehensive understanding of the causes and severity of harm.

Methods

Using five years of patient complaints and staff incident reporting data at a large multi-site hospital in London (in the United Kingdom), this study conducted retrospective patient-level data linkage to identify overlapping reports. Using a combination of quantitative coding and in-depth qualitative analysis, we then compared level of harm reported, identified descriptions of adjacent events missed by the other party and examined combined narratives of mutually identified events.

Results

Incidents where complaints and incident reports overlapped (n = 446, reported in 7.6%’ of all complaints and 0.6% of all incident reports) represented a small but critical area of investigation, with significantly higher rates of Serious Incidents and severe harm. Linked complaints described greater harm from safety incidents in 60% of cases, reported many surrounding safety events missed by staff (n = 582), and provided contesting stories of why problems occurred in 46% cases, and complementary accounts in 26% cases.

Conclusions

This study demonstrates the value of using patient complaints to supplement, test, and challenge staff reports, including to provide greater insight on the many potential factors that may give rise to unsafe care. Accordingly, we propose that a more holistic analysis of critical safety incidents can be achieved through combining heterogeneous data from different viewpoints, such as through the integration of patient complaints and staff incident reporting data.
Implementation of the Australasian Teletrial Model: Translating ideas into action using implementation science frameworks
Authors: Sabesan Sabe , Malica Marie , Gebbie Chantal , Scott Clare , Thomas David , Zalcberg John
Published: July 2021

Background: Despite Government investment, disparity in access to clinical trials continue between metropolitan and regional & rural sectors (RRR) in Australia and around the world. To improve trial access closer to home for RRR communities and rare cancer patients even in metro settings, the Australasian Teletrial Model (ATM) was developed by Clinical Oncology Society of Australia and implemented in four states. Aim of this paper is to describe the steps and processes involved in the development and implementation of ATM guided by implementation science frameworks. Method: Two implementation science frameworks namely iPARIHS and Strategic Implementation Framework were chosen to guide the project. Details of steps and processes were extracted from COSA final report. Results: ATM met the criteria for worthy innovation. For the development and implementation of the ATM, stakeholders were at national, statewide and clinical levels. A co-design with end-users and inclusion of key stakeholders in steering committees and advisory groups made the implementation smoother. Clinician levers including advocacy were useful to overcome system barriers. During the project, more patients, and clinicians at RRR participated in trials, more primary sites collaborated with RRR sites and more RRR sites gained trial capabilities. Conclusion: Pilot project achieved its objectives including improved access to patients locally, creation of linkages between metro and RRR sites and enhanced capabilities of and access to RRR sites. Implementation science frameworks were useful for identifying the necessary steps and processes at the outset. Ownership by governments and creation of streamlined regulatory systems would enable broader adoption.
The effectiveness of telehealth for a caregiver wellness program
Authors: Serwe Katrina M , Walmsley Angela LE
Published: July 2021

Introduction

This study compared outcomes of a telehealth and in-person delivered caregiver wellness program called Powerful Tools for Caregivers (PTC).

Methods

A total of 11 pairs of PTC class leaders delivered in-person and telehealth PTC classes. Caregiver participants completed a health-related questionnaire one week before, one week after, and six months after completing the program. A split-plot, mixed-design analysis of variance (ANOVA) and t tests were used to examine attendance and health-related outcome measures: depression as measured by the Center for Epidemiological Studies Depression Scale-Revised (CESD-R), caregiver experience as measured by the Bakas Caregiving Outcomes scale (BCOS), caregiver self-efficacy, and number of negative self-care behaviors.

Results

A total of 72 caregivers attended PTC in-person and 42 attended via telehealth. Mean attendance was 4.97 ± 1.21 for the in-person group and 5.21 ± 0.071 for the telehealth group, with no significant difference between delivery formats t(112) = 1.074, p = 0.285; 23 caregivers completed all three assessment periods for ANOVA. Interaction of group and time was non-significant for all outcome measures and the main effect of group was only significant for CESD-R scores at pre-PTC assessment, indicating that there were no differences between the two delivery formats for outcomes at post test or six months. The effect of time was significant for all outcome measures, indicating both in-person and telehealth participants improved on health-related outcomes over time.

Discussion

Telehealth is an effective delivery format for PTC – a traditionally in-person caregiver wellness program. This trial was registered [ClinicalTrials.gov identifier: NCT03800238].
The relationship between theory of mind and sluggish cognitive tempo in school-age children with attention deficit and hyperactivity disorder
Authors: Sevincok Doga , Avcil Sibelnur , Ozbek Mutlu M
Published: July 2021

Sluggish cognitive tempo (SCT) is considered as a cognitive-emotional style. Theory of mind (ToM) skills form the basis of human cognition and social behavior. The aim of this study is to contribute to SCT literature by examining the relationship between SCT and cognitive and affective ToM in school-age children with attention deficit and hyperactivity disorder (ADHD). Fifty school-age children with ADHD (43 boys and seven girls) and 40 typically developing children (34 boys and six girls) were assessed using Parent-rated Barkley Child Attention Scale and Child Behavior Checklist/6–18, cognitive (first- and second-order ToM) and affective ToM (Reading Mind in the Eyes Test and Unexpected Outcomes Test (UOT)) tests. Multiple linear regression analysis was performed to determine the variables that may predict SCT levels in children with ADHD. Attention deficit and hyperactivity disorder-inattention (Exp(B) = .334, p = .027), internalization (Exp(B) = .305, p = .006), and UOT scores (Exp(B) = .933, p = .015) significantly predicted SCT severity in children with ADHD. SCT severity was significantly associated with impaired cognitive ToM skills as measured by second-order ToM (Exp(B) = 1.933, p = .045). Our findings may indicate that affective ToM developing with age, and impaired cognitive ToM skills are associated with increasing SCT severity.
Literacy instruction for autistic children who speak languages other than English
Authors: Bailey Benjamin , Arciuli Joanne
Published: July 2021

Much of what is known about autism and literacy instruction is derived from studies including monolingual English-speaking children. Yet, less than one-fifth of the world’s population are English speakers. This review examines the research on literacy instruction for children with autism learning to read and write in languages other than English. A systematic search of the literature identified potentially relevant publications, a relatively small number of these met inclusion criteria. The included studies investigated instruction methods targeted at word reading and spelling, reading comprehension, and written expression for autistic children learning to use alphabetic, syllabary or logosyllabary writing systems. Autistic children benefitted from literacy instruction methods designed for typically developing children. However, some studies showed that additional skills and supports may be required. The included studies also highlight some potential differences in effective instruction practices used when working with autistic children learning alphabetic, syllabary and logosyllabary writing systems. Studies tended to include small samples. We hope this review will bring increased awareness and research efforts in the area of autism and global literacy.

Lay abstract

Many autistic children across the globe speak languages other than English. However, much of the research about teaching children with autism to read and write is derived from studies including people who speak English and no other languages. Here, we review the research on teaching children with autism to read and write in languages other than English. We did this because the world’s languages, and the ways they are represented in written form, vary greatly. A broader overview that encompasses languages other than English can help us better understand how learning to read and write can be supported for autistic children around the world. The studies included in our review highlight some potential differences in effective literacy teaching for autistic children learning to read and write using different writing systems. The studies we reviewed tended to include relatively small samples of autistic children, among other limitations. We hope that our review will increase awareness and research efforts in the area of autism and global literacy.
Indoor thermal climate after energy efficiency measures of a residential building in a sub-Arctic region: Comparing ANSYS CFX and IDA ICE methods
Authors: Lundqvist Petter , Risberg Mikael , Westerlund Lars
Published: July 2021

A residential building which had been subjected to an energy efficiency measures study had its indoor thermal climate investigated using two software approaches to understand how each approach would predict the outcome, using the predicted percentage of dissatisfied (PPD). The computational fluid dynamics software (ANSYS CFX) and the building performance simulation (BPS) software (IDA ICE) were used to simulate the indoor thermal climate before and after the measures. The measures included additional insulation and changing the ventilation system. The results showed a difference in how the software packages handled the thermal radiation. The difference was also because CFX could calculate the indoor thermal climate of the whole interior. While the PPD values could remain similar between the CFX solutions, the area with dissatisfaction in the apartment was decreased when the building envelope was improved. These changes gave an improvement for the CFX solutions, which was not possible to predict with IDA ICE because only the central node was visible. The user should be aware of the shortcomings of BPS and building energy simulation software when evaluating the indoor thermal climate to predict changes. A coupling between BPS and CFX software should be considered when new measures or significant changes are planned.
The promise of personalisation: Exploring how music streaming platforms are shaping the performance of class identities and distinction
Authors: Webster Jack
Published: July 2021

Not only do music streaming platforms offer on-demand access to vast catalogues of licensed music, they are actively shaping what and how it finds us through personalisation. While existing literature has highlighted how personalisation has the potential to transform the part that music taste and consumption play in the performance of class identities and distinction, little is empirically known about its sociological consequences. Drawing on 42 semi-structured interviews with a combination of key informants and Spotify users, this article demonstrates that personalisation is undermining opportunities to achieve social distinction by taking over the labour of music curation and compressing the time needed to appreciate music for its own sake. It demonstrates that those with cultural capital at stake – in the case of this study, young, (primarily) male cultural omnivores – experience personalisation as a threat, highlighting how particular claims to social distinction are being contested in the platform age.
Algorithmic personalization of source cues in the filter bubble: Self-esteem and self-construal impact information exposure
Authors: Knobloch-Westerwick Silvia , Westerwick Axel
Published: July 2021

How do users pick out online information sources? Building on a self-regulation perspective to media use, this study investigates routes to self-enhancement (i.e. state self-esteem [SSE] increase) through selective exposure to sources of political online information. Personal-self importance (PSI) and social-self importance (SSI) were conceptualized as moderators of self-enhancement. An experiment mimicked the filter bubble, as participants ( n = 88) browsed only attitude-aligned political content. The experiment varied source cues, with two (of eight) bylines displaying individual participants’ name initials as author initials. The selective exposure time participants spent on messages from same-initials authors was logged to capture egotism (based on the well-established name-letter effect). Pre-exposure SSE influenced self-enhancement, contingent upon both PSI and SSI. Perceived source similarity affected post-exposure SSE, contingent upon the same moderators. The findings show that algorithms can personalize source cues to attract users and impact self-esteem.
Influences of C5 esters addition on anti-knock and auto-ignition tendency of a gasoline surrogate fuel
Authors: Liang Xin , Duan Yaozong , Fan Yunchu , Huang Zhen , Han Dong
Published: July 2021

The research octane numbers and auto-ignition characteristics of a toluene primary reference fuel (TPRF), when blended with three C5 esters, γ-valerolactone (GVL), methyl butanoate (MB), and methyl crotonate (MC), were investigated on a cooperative fuel research (CFR) engine and a constant volume combustion chamber (CVCC). In fuel preparation, ethanol was used to improve the miscibility, and the total additive comprised 1/3 ethanol and 2/3 GVL/MB/MC on a molar basis. The experimental results first reveal that the addition of the three series of additives boost fuel octane rating, and their boosting effects rank as MB > GVL ∼ MC when fuels are blended on a molar basis. In contrast, the auto-ignition tendency of the three series of fuel blends, when blended on the molar basis, ranks as the MC blends > the GVL blends> the MB blends. Different from the similar reactivities observed for the MC blends and the GVL blends in the RON tests, the MC blends exhibit higher auto-ignition propensity than the GVL blends, probably because the higher enthalpy of vaporization of GVL causes a more significant cooling effect. Finally, different from the literature studies that reported similar reactivities for pure MB and MC, in this study MB shows lower reactivity than MC when blending with the TPRF gasoline surrogate.
An alternative quantification of the value of information in structural health monitoring
Authors: Chadha Mayank , Hu Zhen , Todd Michael D
Published: July 2021

Analogous to an experiment, a structural health monitoring (SHM) system may be thought of as an information-gathering mechanism. Gathering the information that is representative of the structural state and correctly inferring its meaning helps engineers (decision-makers) mitigate possible losses by taking appropriate actions (risk-informed decision-making). However, the design, research, development, installation, maintenance, and operation of an SHM system are an expensive endeavor. Therefore, the decision to invest in new information is rationally justified if the reduction in the expected losses by utilizing newly acquired information is more than the intrinsic cost of the information acquiring mechanism incurred over the lifespan of the structure. This article investigates the economic advantage of installing an SHM system for inference of the structural state, risk, and lifecycle management by using the value of information (VoI) analysis. Among many possible choices of SHM system designs (different information-gathering mechanisms), pre-posterior decision analysis can be used to select the most feasible design. Traditionally, the cost–benefit analysis of an SHM system is carried out through pre-posterior decision analysis that helps one evaluate the benefit of an experiment or an information-gathering mechanism using the expected value of information metric. This study proposes an alternate normalized metric that evaluates the expected reward ratio (benefit/gain of using an SHM system) relative to the investment risk (cost of SHM over the lifecycle). The analysis of evaluating the relative benefit of various SHM system designs is carried out by considering the concept of the VoI, by performing pre-posterior analysis, and the idea of a perfect experiment is discussed.
Conceptual approaches to the development of continuing medical education for general practitioners in Moscow
Authors: Morozova TE , Volnuhin AV , Gertsog AA , Zhukov VA , Zaugol'nikova TV , Samokhina EO , Chegayeva TV
Published: July 2021

The article is devoted to the current state of continuing medical education for general practitioners in the city of Moscow and is based on a survey of general practitioners working in Moscow. Results demonstrate a lack of satisfaction with the organisation and content of training in its previous format, the absence of significant changes in the learning objectives following education reform and an ambiguous attitude towards this reform. The minimum continuing education requirements for general practitioners working in the city of Moscow were shown to consist of day release, short-term training, theoretical and practical orientation and the application of contemporary educational technologies. Conceptual approaches to the development of continuing medical education in the field of general medical practice in Moscow were formulated. These comprised organisation of training, setting of learning objectives, selection of forms and methods of training, determination of interactive training content, application of a competency-based approach and individualisation of the educational path.
Measuring Trauma- (and Violence-) Informed Care: A Scoping Review
Authors: Wathen C. Nadine , Schmitt Brenna , MacGregor Jennifer C. D.
Published: July 2021

Trauma- (and violence-) informed care (T(V)IC) has emerged as an important practice approach across a spectrum of care settings; however how to measure its implementation and impact has not been well-examined. The purpose of this scoping review is to describe the nature and extent of available measures of T(V)IC, including the cross-cutting concepts of vicarious trauma and implicit bias. Using multiple search strategies, including searches conducted by a professional librarian from database inception to Summer 2020, 1074 articles were retrieved and independently screened for eligibility by two team members. A total of 228 were reviewed in full text, yielding 13 measures that met pre-defined inclusion criteria: 1) full-text available in English; 2) describes the initial development and validation of a measure, that 3) is intended to be used to evaluate T(V)IC. A related review of vicarious trauma measures yielded two that are predominant in this literature. Among the 13 measures identified, there was significant diversity in what aspects of T(V)IC are assessed, with a clear emphasis on “knowledge” and “safety”, and less on “collaboration/choice” and “strengths-based” concepts. The items and measures are roughly split in terms of assessing individual-level knowledge, attitudes and practices, and organizational policies and protocols. Few measures examine structural factors, including racism, misogyny, poverty and other inequities, and their impact on people’s lives. We conclude that existing measures do not generally cover the full potential range of the T(V)IC, and that those seeking such a measure would need to adapt and/or combine two or more existing tools.
Prevalence of Physical Violence Against Brazilian Women: Systematic Review and Meta-Analysis
Authors: Nakamura Isabella Bagni , Silva Marcus Tolentino , Garcia Leila Posenato , Galvao Tais Freire
Published: July 2021

Violence against women is a major problem in Brazil, but data on its prevalence are scarce. We aimed to estimate the prevalence of physical violence against women in Brazil. We conducted a systematic review and meta-analysis of the prevalence of physical violence against women. Population-based researches that assessed physical violence in Brazilian women were searched on MEDLINE, Embase, Scopus, and VHL/BIREME. The last search update was carried out in March 2020. Two researchers selected the studies, extracted the data, and assessed the quality of the eligible studies. Summary of prevalence and 95% confidence interval (CI) was calculated using Freeman–Tukey double arccosine transformation, weighted by the official local population size. Heterogeneity was estimated by I 2 and investigated by meta-regression analyses. Of 3,408 reports, 13 studies carried out from 1999 to 2016 ( n = 25,781 women) were included. Most studies had limitations on sample size (5/13) and response rate (7/13). The prevalence of physical violence was 22.4% in lifetime (95% CI [21.6, 23.2%]; I 2 = 99.0%), and 11.5% in previous year (95% CI [11.1, 11.9%]; I 2 = 99.5%). Assuring privacy during interview significantly increased the prevalence ( p = .028; residual I 2 = 80.0%). Higher prevalence was also observed in studies with adequate sample source, validated questionnaire, and privacy (in both recall periods), potentially due to lower risk of nonresponse bias. Over two in 10 Brazilian women suffered physical violence during their lives, and over one tenth, in the previous year. Measurement of outcome affected the prevalence; privacy should be assured for the interviewee for future reliable estimates in the country.
Financial Returns in Major League Soccer
Authors: Bradbury John Charles
Published: July 2021

Major League Soccer (MLS) is the top-tier professional soccer league serving the United States and Canada. This study examines factors hypothesized to impact consumer demand for professional sports on team revenue in this nascent league. The estimates are consistent with positive returns to performance, novelty effects from newer teams, and varying impacts from roster quality and composition. Other factors hypothesized to be important for MLS teams (e.g., stadium quality and market demographics) are not associated with team revenue. The estimates are similar to findings in other major North American sports leagues, even though MLS operates with a unique single-entity ownership structure that has the potential to disincentivize individual team investments by league owners.
A comparison between solvent casting and electrospinning methods for the fabrication of neem extract-containing buccal films
Authors: Rohani Shirvan Anahita , Hemmatinejad Nahid , Bahrami S Hajir , Bashari Azadeh
Published: July 2021

In the present study a double layer mucoadhesive buccal film containing nanocarriers encapsulated with neem extract was fabricated through electrospinning and solvent casting techniques for dental therapeutic applications. The morphological, physical and mucoadhesive properties of the resulting electrospun and solvent cast oral films were mutually compared, and their drug release behavior and antibacterial activity were further investigated. Chitosan/poly(vinylalcohol) (PVA) as a mucoadhesive component and phenylalanine amino acid nanotubes (PhNTs)-containing neem extract as a drug nanocarrier were used to fabricate oral films. A poly(caprolactone) (PCL) layer was used as an impermeable backing layer to protect the mucoadhesive component from tongue movement and drug loss. The results indicated an interconnected porous and fully filled solid structures for electrospun and solvent cast films, respectively. The physicomechanical parameters of the samples such as pH, weight, thickness, folding endurance and tensile strength were also evaluated. The crosslinked electrospun buccal film indicated better swelling and mucoadhesive properties compared to the solvent cast film. In addition, the drug loading capacity and encapsulation efficiency of the solvent cast film showed lower experimental values than those of electrospun oral film. On the other hand, the electrospun oral film had a well-controlled release of neem extract up to 82% at oral pH, which is best fitted to the Weibull model, and demonstrated the highest antibacterial properties against S. mutans bacteria with high biocompatibility on L929 fibroblast cells. Generally, the synthesized electrospun mucoadhesive film has a better potential for oral therapeutic applications than the solvent cast film.
Association of genetic variants rs641153 (CFB), rs2230199 (C3), and rs1410996 (CFH) with age-related macular degeneration in a Brazilian population
Authors: Neto Jamil M , Viturino Marina GM , Ananina Galina , Bajano Flávia F , Costa Sueli M da S , Roque Alicia B , Borges Gessica FS , Franchi Raissa , Rim Priscila HH , Medina Flávio M , Costa Fernando F , Melo Mônica B de , de Vasconcellos José PC
Published: July 2021

This study aimed to investigate the association among genetic variants of the complement pathway CFB R32Q (rs641153), C3 R102G (rs2230199), and CFH (rs1410996) with age-related macular degeneration (AMD) in a sample of the Brazilian population. In a case-control study, 484 AMD patients were classified according to the clinical age-related maculopathy grading system (CARMS) and compared to 479 unrelated controls. The genetic variants rs1410996 of complement H (CFH), rs641153 of complement factor B (CFB), and rs2230199 of complement 3 (C3) were evaluated through polymerase chain reaction (PCR) and direct sequencing. The associations between single nucleotide polymorphisms (SNPs) and AMD, adjusted by age, were assessed by using logistic regression models. A statistically significant association was observed between AMD risk and rs2230199 variant with an OR of 2.01 ( P  = 0.0002) for CG individuals compared to CC individuals. Regarding the comparison of advanced AMD versus the control group, the OR was 2.12 ( P = 0.0036) for GG versus AA genotypes for rs1410996 variant. Similarly, the OR for rs2230199 polymorphism was 2.3034 ( P  = 5.47e-05) when comparing CG individuals to CC carriers. In contrast, the rs641153 variant showed a significant protective effect against advanced AMD for GA versus GG genotype (OR = 0.4406; P  = 0.0019). When comparing wet AMD versus controls, a significant association was detected for rs1410996 variant (OR = 2.16; P  = 0.0039) comparing carriers of the homozygous GG versus AA genotype, as well as in the comparisons of GG (OR = 3.0713; P  = 0.0046) and CG genotypes (OR = 2.2249; P  = 0.0002) versus CC genotype for rs2230199 variant, respectively. The rs641153 variant granted a significant protective effect against wet AMD for GA versus GG genotypes (OR = 0.4601; P  = 0.0044). Our study confirmed the risk association between rs2230199 and rs1410996 variants and AMD, and the protective role against AMD for rs641153 variant.
Megestrol acetate drives endometrial carcinoma cell senescence via interacting with progesterone receptor B/FOXO1 axis
Authors: Wang Hong , Shi Huirong
Published: July 2021

Megestrol acetate is a common and efficient anticancer progesterone. To explore the activity and the therapeutic mechanisms of megestrol acetate in endometrial cancer, human endometrial cancer cell lines Ishikawa and HHUA overexpressing progesterone receptor A (PR-A) and progesterone receptor B (PR-B) were treated with megestrol acetate. Cell viability, apoptosis, cycle arrest, and senescence, as well as the expressions of p21 and p16, two hallmarks of cellular senescence, were evaluated. Compared with the control, >10 nmol/L megestrol acetate treatment could significantly reduce endometrial cancer cell growth, and induce the irreversible G1 arrest and cell senescence. The expression of cyclin D1 in megestrol acetate treated cells was downregulated, while the expressions of p21 and p16 were upregulated via PR-B isoform. FOXO1 inhibitor AS1842856 could significantly abrogate megestrol acetate-induced cell senescence, suggesting that FOXO1 was involved in megestrol acetate/PR-B axis. These findings may provide a new understanding for the treatment of human endometrial cancer.
Parathyroid hormone promotes cartilage healing after free reduction of mandibular condylar fractures by upregulating Sox9
Authors: Jia Yuanyuan , Xie Liuqin , Tang Zhenglong , Wang Dongxiang , Hu Yun , Zhang Guoxing , Chen Youli , Gao Qiong
Published: July 2021

After high fractures of the mandibular condyle, the insufficient blood supply to the condyle often leads to poor bone and cartilage repair ability and poor clinical outcome. Parathyroid hormone (PTH) can promote the bone formation and mineralization of mandibular fracture, but its effects on cartilage healing after the free reduction and internal fixation of high fractures of the mandibular condyle are unknown. In this study, a rabbit model of free reduction and internal fixation of high fractures of the mandibular condyle was established, and the effects and mechanisms of PTH on condylar cartilage healing were explored. Forty-eight specific-pathogen-free (SPF) grade rabbits were randomly divided into two groups. In the experimental group, PTH was injected subcutaneously at 20 µg/kg (PTH (1–34)) every other day, and in the control group, PTH was replaced with 1 ml saline. The healing cartilages were assessed at postoperative days 7, 14, 21, and 28. Observation of gross specimens, hematoxylin eosin staining and Safranin O/fast green staining found that every-other-day subcutaneous injection of PTH at 20 µg/kg promoted healing of condylar cartilage and subchondral osteogenesis in the fracture site. Immunohistochemistry and polymerase chain reaction showed that PTH significantly upregulated the chondrogenic genes Sox9 and Col2a1 in the cartilage fracture site within 7–21 postoperative days in the experimental group than those in the control group, while it downregulated the cartilage inflammation gene matrix metalloproteinase-13 and chondrocyte terminal differentiation gene ColX. In summary, exogenous PTH can stimulate the formation of cartilage matrix by triggering Sox9 expression at the early stage of cartilage healing, and it provides a potential therapeutic protocol for high fractures of the mandibular condyle.
Coil-In-Plug Technique Using the Amplatzer Vascular Plug II to Occlude a Portosystemic Shunt
Authors: Nagatomi Satoru , Ichihashi Shigeo , Yamamoto Hiroshi , Bolstad Francesco , Kichikawa Kimihiko
Published: July 2021

Introduction

The family of Amplatzer Vascular Plugs (AVPs) is characterized by their precise deployment and high resistance to migration. However, a risk of recanalization of the embolized vessels has been reported. To augment the effectiveness of embolization, the coil-in-plug (CIP) technique was developed, exclusively using AVP I or IV. However, these plugs cannot be used for large vessels like portovenous shunt because of the size limitation. AVP II has a larger-sized model up to 22 mm. This article reports two cases of embolizing high-flow and large-caliber portosystemic shunts where the CIP technique with multilayer AVP II was effectively employed.

Materials and methods

The CIP technique using AVP II was utilized for one case with a portocaval shunt and another with a splenorenal shunt. CIP was established with wire penetration through the multilayer meshes, followed by a microcatheter insertion. After the microcatheter was positioned in the central lobe, the internal space was embolized tightly using pushable or detachable coils.

Results

A use of guidewire with a high tip load enabled an establishment of CIP and complete occlusion of the target vessels immediately without migration of the embolic devices in both cases. The symptom of encephalopathy improved after the procedure in both the case of the portocaval and the splenorenal shunt.

Conclusion

The CIP technique with the AVP II was safe and effective to achieve complete occlusion of the large-caliber portosystemic shunts.
Femoral Artery Branch Pseudoaneurysm Resulting From Muscle Strain Injury
Authors: Kashtanjeva Besnike
Published: July 2021

A 66 year old male presented with pain and swelling isolated to the right thigh after a bout of vigorous exercise on a step treadmill. We report a muscle strain injury resulting in formation of a pseudoaneurysm arising from a branch of the mid superficial femoral artery. The pseudoaneurysm was incidentally discovered during a venous ultrasound examination. Within two weeks of its finding, the pseudoaneurysm had resolved.
Flow pulsation reduction of a single-piston piezoelectric pump based on elastic cavity group and unloading valve
Authors: Wang Bin , Xu Nanyue , Yang Rongfei
Published: July 2021

A piston piezoelectric (PZT) pump has many advantages for the use of light actuators. How to deal with the contradiction between the piston amount and oil delivery quality is an essence when designing the pump. In order to depress the pressure pulsation and flow pulsation in a single-piston PZT pump, a two-stage attenuator is proposed. It involves an elastic cavity group and an unloading valve. Unsteady flow inside the pump is numerically calculated and analyzed to reveal its delivery characteristic in the whole pumping cycle. The distributing process of the passive valves is obtained through the dynamic mesh technique. Influences of key design and operation factors on the delivery performance of the pump are analyzed. The results indicate that the flexible cavity group and the unloading valve arranged at the delivery port can reduce the flow pulsation by 45%. The design can effectively provide stable flow for the actuator in a certain frequency range.
Influence of structural elasticity on transshipment dynamics of dual-trolley overhead crane
Authors: Yao Xiaoguang , Feng Yongbao , Meng Lijun , Yao Liang , Li Hongbin
Published: July 2021

This paper studied the dynamic process of a dual-trolley overhead crane transshipping rigid-body cargo with degrees of spatial freedom. By taking the tensile stiffness of wire rope, the bending stiffness of box girder and the mass of cargo as variables, six different working conditions were calculated. The influences of the variables on spatial movement of slender cargo were analyzed. To verify the presented analytic model, a virtual prototype model was constructed by using the commercial software ADAMS and ANSYS. The consistency of the calculation results from the two different models proves the effectiveness of the analytic model presented in this paper.
Multilevel analysis of evolution of team process and their relation to performance in semi-professional soccer
Authors: Leo Francisco M , López-Gajardo Miguel A , Pulido Juan J , González-Ponce Inmaculada
Published: July 2021

The aim of the study was to examine the evolution of players' perception of group variables (leadership, motivational climate, cohesion, and collective efficacy) and to determine whether the intercept and growth trajectory differed as a function of whether expectations have or have not been met in a sample of semi-professional Spanish football players. The results show that the levels of the variables (except for autocratic leadership and coach-created ego climate) decrease over the season. Furthermore, the mean scores of the “fully meets expectations” group were significantly higher in positive leader characteristics, coach-created task climate, cohesion and collective efficacy. Also, rates of decline were significantly greater in the “does not meet expectations” group. The results indicate the importance of establishing reachable expectations by coaches and players because to achieve or to miss the expected goals can affect psychological group dynamics.
Links Between Musicality and Vocal Emotion Perception
Authors: Nussbaum Christine , Schweinberger Stefan R.
Published: July 2021

Links between musicality and vocal emotion perception skills have only recently emerged as a focus of study. Here we review current evidence for or against such links. Based on a systematic literature search, we identified 33 studies that addressed either (a) vocal emotion perception in musicians and nonmusicians, (b) vocal emotion perception in individuals with congenital amusia, (c) the role of individual differences (e.g., musical interests, psychoacoustic abilities), or (d) effects of musical training interventions on both the normal hearing population and cochlear implant users. Overall, the evidence supports a link between musicality and vocal emotion perception abilities. We discuss potential factors moderating the link between emotions and music, and possible directions for future research.
The Missing Link in Early Emotional Processing
Authors: Carretié Luis , Yadav Raghunandan K. , Méndez-Bértolo Constantino
Published: July 2021

Initial evaluation structures (IESs) currently proposed as the earliest detectors of affective stimuli (e.g., amygdala, orbitofrontal cortex, or insula) are high-order structures (a) whose response latency cannot account for the first visual cortex emotion-related response (~80 ms), and (b) lack the necessary infrastructure to locally analyze the visual features that define emotional stimuli. Several thalamic structures accomplish both criteria. The lateral geniculate nucleus (LGN), a first-order thalamic nucleus that actively processes visual information, with the complement of the thalamic reticular nucleus (TRN) are proposed as core IESs. This LGN–TRN tandem could be supported by the pulvinar, a second-order thalamic structure, and by other extrathalamic nuclei. The visual thalamus, scarcely explored in affective neurosciences, seems crucial in early emotional evaluation.
The Sympathetic Plot, Its Psychological Origins, and Implications for the Evolution of Fiction
Authors: Singh Manvir
Published: July 2021

The sympathetic plot—featuring a goal-directed protagonist who confronts obstacles, overcomes them, and wins rewards—is ubiquitous. Here, I propose that it recurs because it entertains, engaging two sets of psychological mechanisms. First, it triggers mechanisms for learning about obstacles and how to overcome them. It builds interest by confronting a protagonist with a problem and induces satisfaction when the problem is solved. Second, it evokes sympathetic joy. It establishes the protagonist as an ideal cooperative partner pursuing a goal, appealing to mechanisms for helping. When the protagonist succeeds, they receive rewards, and audiences feel sympathetic joy, an emotion normally triggered when beneficiaries triumph. The capacities underlying the sympathetic plot evolved for learning and cooperation before being co-opted for entertainment.
Proclaiming a prophecy empty of substance? A pragmatist reconsideration of global governance
Authors: Franke Ulrich , Hofferberth Matthias
Published: July 2021

In 1995, the UN Commission on Global Governance published their “Our Global Neighbourhood” report and the academic journal “Global Governance: A Review of Multilateralism and International Organizations” was launched. Both events in retrospect play a significant role in the emergence of global governance thinking and practice in world politics. Despite inherent ambiguities, this idea since then gained massive traction and became both a modality and a heuristic of world politics. Advancing a pragmatist framework, we unpack global governance in terms of the beliefs which underline and guide it. These beliefs are important since they, as rules for action, define the scope of global governance as a theoretical and a political concept. Reconstructing these beliefs directly from the 1995 report, the article highlights the inherent conflations of normative and analytical commitments indicative of global governance. As a projection surface of all kinds, we believe such a reconsideration of global governance is important to (a) reveal the baselines of its thinking and practice, (b) indicate how its normative and analytical ambitions overlap and conflate, and (c) contribute to a more reflective discussion on the idea which explicitly considers its inherent normativity. At the same time, we hope to show the value of a pragmatist framework on beliefs for the study of world politics.
Neoadjuvant immunotherapy for muscle invasive urothelial bladder carcinoma: will it change current standards?
Authors: Renner Alex , Burotto Mauricio , Valdes Jose Miguel , Roman Juan Carlos , Walton-Diaz Annerleim
Published: July 2021

Immunotherapy, in the form of immune checkpoint inhibitors (ICI), has shown activity in metastatic urothelial bladder carcinoma, resulting in the approval of several ICI agents in the first- and second-line settings. This has led to an increased interest in studying their efficacy in the neoadjuvant setting for muscle invasive disease – an area of significant unmet need. This non-systematic review will look at the evidence supporting the use of ICI in the neoadjuvant setting for this tumor, results of early-phase studies, ongoing trials, and possible future applications for these drugs.
The Impact of Communication Information on the Perceived Threat of COVID-19 and Stockpiling Intention
Authors: Giroux Marilyn , Park Jooyoung , Kim Jae-Eun , Choi Yung Kyun , Lee Jacob C. , Kim Seongseop (Sam) , Jang Seongsoo , Gonzalez-Jimenez Hector , Kim Jungkeun
Published: July 2021

This article investigates the role of diverse nudging communication strategies on perceived threat and stockpiling intention. Across three studies, the authors examined the various effects of “nudging” on consumer behavior. Study 1 demonstrates that a commonly used picture has a stronger impact on perceived threat than a less frequently exposed picture regardless of its accuracy. Study 2 shows that the perceived threat of COVID-19, in terms of severe health consequences, is lower when using an indirect (vs. direct) explanation of the virus, as well as when reducing the amount of information about the virus. Study 3 investigates the impact of salient negative information and childhood socioeconomic status (SES). Findings reveal that negative information about deaths associated with the virus increases the level of perceived threat and stockpiling intention, especially among people of low childhood SES.
Identifying Best Practices for Managing Internal Carotid Artery Injury During Endoscopic Endonasal Surgery by Consensus of Expert Opinion
Authors: Kassir Zachary M. , Gardner Paul A. , Wang Eric W. , Zenonos Georgios A. , Snyderman Carl H.
Published: July 2021

Background

Injury to the internal carotid artery (ICA) is a potentially devastating complication of endoscopic endonasal surgery (EES) that as many as 20% of skull base surgeons will experience at least once during their careers. Managing these injuries is difficult given the small operative field and poor visibility created by high-flow hemorrhage, and, at present, there is no consensus regarding best practices.

Objective

This study seeks to consolidate the practices and opinions of experienced skull base surgeons from high-volume tertiary care centers into a single consensus statement regarding the best practices for managing ICA injuries during EES.

Methods

A panel of 23 skull base surgeons (15 neurosurgeons and 8 otolaryngologists) completed a 3-round Delphi survey that assessed experiences and opinions regarding various aspects of ICA injury management. Mean (SD) years since fellowship completion was 15.6 (8.1) and all but 3 surgeons had experienced an ICA injury at least once.

Results

The final consensus statement included 36 guidelines all of which were grouped under 1 of 4 categories: 11 statements concerned preoperative management and equipment for high-risk patients; 14 statements concerned hemorrhage control; 4 statements concerned definitive management; 7 statements concerned pharmacologic treatment, blood pressure, and neurophysiologic monitoring.

Conclusions

There are numerous decisions that a surgeon must make when facing a carotid artery injury. In our estimation, many questions can be grouped under 1 of the 4 categories outlined in our consensus statement and can be addressed by these findings.
Safety of Endoscopic Sinus Surgery in the Elderly—Are Octogenarian Patients at a Higher Risk?
Authors: Levi Lirit , Reuven Yonatan , Ben-Ner Daniel , Koch Noam , Gunders-Peleg Mor , Nachalon Yuval , Koren Ilan , Hazan Alain , Nakache Gabriel , Reifen Ella , Soudry Ethan
Published: July 2021

Background

Surgeons are often faced with concerns regarding the risks versus benefits of endoscopic sinus surgery (ESS) in elderly patients.

Objective

To analyze the risk for complications of ESS in the elderly (age ≥70 years) compared to younger patients, with emphasis on octogenarians.

Methods

Retrospective review of medical charts of adult patients who underwent ESS at a tertiary referral center during the years 2014 to 2018.

Results

We compared 128 elderly patients with 276 matched younger patients. In the elderly group mean age was 76 years (range, 70-91 years ). Thirty-one elderly patients were 80 years or older. Surgical complications in the elderly patients were 3.9%. Minor complications were 2.3% and major complications were 1.7%. The surgical complications rate was similar in the younger group (8%, P value: .127). Medical complications were observed in 2.3% comparing to 0.7% in younger patients. Interestingly, age, revision surgery, extent and duration of surgery, and modality of anesthesia were not identified as risk factors. Only ischemic heart disease (IHD) was identified as a risk factor for complications in a multivariate analysis in elderly patients. Comparison of elderly patients younger than 80 years with octogenarians revealed no difference in complication rate between these groups.

Conclusions

Overall, ESS was found to be a safe procedure in elderly patients compared to younger patients. Octogenarian patients should not be denied upfront surgery. IHD is a risk factor for complications in elderly patients.