bluuebunny/crossref_metadata_2025 huggingface dataset:
Um grito parado no ar: o proferimento ‘Lula Livre’ como expressão da política da eternidade
Authors: Lopes da Silva Fábio
Published: December 2019

Neste ensaio, abordo o proferimento ‘Lula Livre’, principal palavra de ordem daesquerda brasileira desde o episódio da prisão do ex-presidente Lula, em abril de 2018. Articulando a filosofia austiniana da linguagem às considerações do historiador americano Timothy Snyder a respeito da política contemporânea, procuro mostrar que ‘Lula Livre’, à diferença dos performativos em geral, não se projeta em direção ao futuro como um enunciado potencialmente capaz de modificar as circunstâncias em que é produzido. Em lugar disso, inscreve-se em uma concepção circular de tempo, no interior da qual a vida é experimentada como defesa permanente da própria inocência ante investidas cíclica e indefinidamente perpetradas por um suposto inimigo externo
Conceito de Letramento e a Formação de Professores de Línguas
Authors: Garcez Pedro De Moraes
Published: December 2019

Que relevância ou utilidade tem o conceito de letramento no que tange à formação de educadores (da linguagem)? Partindo de uma definição de letramento de larga circulação entre nós, discuto dificuldades para o emprego consistente do termo. Propondo cautela ao relacionar letramento diretamente com aprendizagem, destaco a necessidade de reflexão sobre as concepções de ação pelo uso da linguagem coerentes com tomar o conceito de letramento como relevante e útil com vistas à educação linguística escolar. Para articular isso com educação linguística e formação de professores, apresento minhas convicções acerca do propósito da educação linguística escolar e do lugar da reflexão metalinguística no ensino de línguas. Alertando para uma compreensão equivocada de que os gêneros textuais[/]discursivos seriam – eles próprios – objetos de ensino, reitero a convicção de que, tendo o letramento como pronto de referência, “uma abordagem funcional e estrutu­rante” (SIMÕES; FILIPOUSKI; MARCHI, 2009, p. 49) dos gêneros permite uma arquitetura didático-pedagógica para a educação linguística escolar. Por fim, referindo propostas coletivas de organização curricular para a educação linguística escolar pautadas pela noção de letramento, argumento que iniciativas de formação devem fomentar o protagonismo de professores-autores-formadores com vistas a uma educação linguística escolar satisfatória frente às demandas e contradições da contemporaneidade.
Letramento e Educação de Surdos
Authors: Nogueira Aryane Santos
Published: December 2019

Neste artigo tematizamos o conceito de letramento a partir da sua retomada nos estudos sobre educação de surdos. Analisamos e argumentamos como esse conceito foi alçado para ressignificar o entendimento das práticas escolares desenvolvidas com alunos surdos, mais especificamente, o ensino da leitura e da escrita em português, num conjunto de textos pertencentes a três publicações – duas do início dos anos 2000, relacionadas a eventos científicos relevantes na área, e outra mais recente, do ano de 2018. Conforme pretendemos mostrar, esses trabalhos constroem, inicialmente, uma interlocução entre o conceito de letramento como prática social e o conceito sociolinguístico de bilinguismo (re)apropriado ao projeto de educação bilíngue para surdos. Nesse processo, instauram-se práticas de língua(gem) específicas a esse contexto, com repercussões diretas no modo como o letramento em sala de aula com alunos surdos vem sendo pensado até os dias de hoje.
Writings on the Wall: Textual Traces of Transit in the Aegean Borderscape
Authors: Wagner Tsoni Ioanna , Franck Anja K.
Published: December 2019

The Greek island of Lesvos has a centuries-old history as a site of departure, arrival, coexistence and resistance for the forcibly displaced. This migratory chronology, however, was overwritten by the unprecedented attention that Lesvos attracted during the 2015 ‘refugee crisis’. This paper examines vernacular aspects of bordering, specifically the practice of border crossers and other groups standing in solidarity with—or against—them, to inscribe messages on walls in and around carceral and public spaces, viewed as a process of constructing and contesting borders from below. Closely reading numerous inscriptions collected around Lesvos reveals how borders are constructed, enacted and contested from below through borderlanders’ discursive practices on some of the very walls that constitute the EU frontier’s material infrastructure. This study aims to advance understandings of the historical continuity of the Aegean borderscape as a complex landscape of border effects and affects that exceed borders’ legal, infrastructural and political dimensions, while also highlighting the persistence and importance of personal agency, self-authorship and identity reclamation by border populations even in the direst of circumstances.
Cross-Border Cooperation in the Carpathian Euroregion: Ukraine and the EU
Authors: Shaban Tatiana
Published: December 2019

Cross-border cooperation among the Eastern neighbours of the European Union can be understood as a new approach to public policy and border governance in the region. There was no border cooperation strategy between communist and European countries during Soviet times. The question of the management of the Eastern border of the EU, especially with Belarus, Ukraine, and Moldova, came on the agenda in 1997, when accession to the union was finally opened to Eastern and Southern European candidates. With the Partnership and Cooperation Agreement that came into force in 1998, Ukraine signalled its foreign policy orientation as European, asserting that Western integration would help modernize its economy, increase living standards, and strengthen democracy and rule of law. The European Commission required “good neighbourly relations” as a further condition for accession and in conjunction, the concept of “Wider Europe” was proposed to set up border-transcending tasks. The Carpathian Euroregion was established to contribute to strengthening the friendship and prosperity of the countries of this region. However, the model was not fully understood and had only limited support of the national governments. This article uses the Carpathian Euroregion as a case study to show that overall Ukraine and the EU’s Eastern neighbourhood presents more opportunities for effective cooperation with the EU rather than barriers or risks.
La « frontière » selon Paul de La Pradelle
Authors: Perrier Benjamin
Published: December 2019

Auteur indispensable sur la « frontière », Paul de Geouffre de La Pradelle est connu pour sa théorie juridique originale. L’auteur fait la distinction entre la « délimitation » (qui est une ligne) et la « frontière » (qui est une zone de coopération). Il différencie également ce qu’il nomme la « frontière nationale » (« objet d’étude du droit public interne ») et la « frontière internationale » (« objet d’étude du droit international public et privé »).
Inhibition of collagen-induced platelet reactivity by DGEA peptide.
Authors: Luzak Boguslawa , Golanski Jacek , Rozalski Marcin , Boncler Magdalena A , Watala Cezary
Published: December 2019

Direct interactions between collagen, the most thrombogenic component of the extracellular matrix, and platelet surface membrane receptors mediate platelet adhesion and induce platelet activation and aggregation. In this process two glycoproteins are crucial: integrin alpha2beta1, an adhesive receptor, and GPVI, which is especially responsible for signal transduction. Specific antagonists of the collagen receptors are useful tools for investigating the complexity of platelet-collagen interactions. In this work we assessed the usefulness of DGEA peptide (Asp-Gly-Glu-Ala), the shortest collagen type I-derived motif recognised by the collagen-binding integrin alpha2beta1, as a potential antagonist of collagen receptors. We examined platelet function using several methods including platelet adhesion under static conditions, platelet function analyser PFA-100TM, whole blood electric impedance aggregometry (WBEA) and flow cytometry. We found that DGEA significantly inhibited adhesion, aggregation and release reaction of collagen activated blood platelets. The inhibitory effect of DGEA on static platelet adhesion reached sub-maximal values at millimolar inhibitor concentrations, whereas the specific blocker of alpha2beta1 - monoclonal antibodies Gi9, when used at saturating concentrations, had only a moderate inhibitory effect on platelet adhesion. Considering that 25-30% of total collagen binding to alpha2beta1 is specific, we conclude that DGEA is a strong antagonist interfering with a variety of collagen-platelet interactions, and it can be recognised not only by the primary platelet adhesion receptor alpha2beta1 but also by other collagen receptors.
Comparative analysis of RCAS1 level in neoplasms and placenta.
Authors: Wicherek Lukasz , Dutsch Magdalena , Mak Pawel , Klimek Marek , Skladzien Jacek , Dubin Adam
Published: December 2019

The tumor associated antigen RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) expressed with high frequency in various cancer and trophoblast cells, inhibits growth of estrogen receptor-expressing cells and induces apoptosis. Because previous reports demonstrated RCAS1 presence only by non-quantitative immunocytochemistry methods, we decided to use a Western blotting with anti-RCAS1 monoclonal antibodies for estimation of the relative content of the tumor-associated antigen. One hundred tissue samples were assayed (neoplasms, chronic inflammatory diseases, healthy tissues, trophoblasts and placentas at term). RCAS1 was present in all neoplastic, placental and trophoblast tissue samples and its level in malignant samples was statistically significantly higher than in benign neoplasms. The amount of RCAS1 in chronic inflammations was also significantly increased in immune mediated diseases, like allergic nasal polyps and sarcoidosis. The RCAS1 protein was not revealed in healthy mucous membrane and in muscle tissues. The presented results suggest that RCAS1 might play an important role in tumor escape from host immunological surveillance and carry weight in the down regulation of the maternal immune response, thereby maintaining pregnancy.
The structure and protein binding of amyloid-specific dye reagents.
Authors: Stopa Barbara , Piekarska Barbara , Konieczny Leszek , Rybarska Janina , Spólnik Paweł , Zemanek Grzegorz , Roterman Irena , Król Marcin
Published: December 2019

The self-assembling tendency and protein complexation capability of dyes related to Congo red and also some dyes of different structure were compared to explain the mechanism of Congo red binding and the reason for its specific affinity for beta-structure. Complexation with proteins was measured directly and expressed as the number of dye molecules bound to heat-aggregated IgG and to two light chains with different structural stability. Binding of dyes to rabbit antibodies was measured indirectly as the enhancement effect of the dye on immune complex formation. Self-assembling was tested using dynamic light scattering to measure the size of the supramolecular assemblies. In general the results show that the supramolecular form of a dye is the main factor determining its complexation capability. Dyes that in their compact supramolecular organization are ribbon-shaped may adhere to polypeptides of beta-conformation due to the architectural compatibility in this unique structural form. The optimal fit in complexation seems to depend on two contradictory factors involving, on the one hand, the compactness of the non-covalently stabilized supramolecular ligand, and the dynamic character producing its plasticity on the other. As a result, the highest protein binding capability is shown by dyes with a moderate self-assembling tendency, while those arranging into either very rigid or very unstable supramolecular entities are less able to bind.
Neural impacts on the regeneration of skeletal muscles.
Authors: Pintér Sándor , Mendler Luca , Dux László
Published: December 2019

The regeneration of skeletal muscles is a suitable model to study the development and differentiation of contractile tissues. Neural effects are one of the key factors in the regulation of this process. In the present work, effects of different reinnervation protocols (suture or grafting) were studied upon the regenerative capacity of rat soleus muscles treated with the venom of the Australian tiger snake, notexin, which is known to induce complete necrosis and subsequent regeneration of muscles. Morphological and motor endplate analysis indicated that the regenerative capacity of denervated, and thereafter surgically reinnervated muscles remains impaired compared to that of normally innervated muscles, showing differences in the muscle size, fiber type pattern and motor endplate structure, even 35 days after the notexin injection. A lack or deficiency of secreted neural factors, deterioration of satellite cells and/or incomplete recovery of the sutured or grafted nerves may be the cause of these discrepancies in the regeneration process.
Alternative oxidase in higher plants.
Authors: Juszczuk Izabela M , Rychter Anna M
Published: December 2019

Plant respiratory chain branches at the level of ubiquinone from where the electrons flow through the cytochrome pathway or to alternative oxidase. Transfer of electrons from ubiquinone to oxygen by alternative oxidase has a non-protonmotive character and, by bypassing two sites of H+ pumping in complexes III and IV, lowers the energy efficiency of respiration. In this paper we review theoretical and experimental studies about the structure and possible function of alternative oxidase. The evidence for specific gene expression dependent on the physiological, developmental and environmental conditions is also described. We underline the physiological role of alternative oxidase as a "survival" protein that allows plants to cope with the stressful environment.
Methylation demand: a key determinant of homocysteine metabolism.
Authors: Brosnan John T , Jacobs Rene L , Stead Lori M , Brosnan Margaret E
Published: December 2019

Elevated plasma homocysteine is a risk factor for cardiovascular disease and Alzheimer's disease. To understand the factors that determine the plasma homocysteine level it is necessary to appreciate the processes that produce homocysteine and those that remove it. Homocysteine is produced as a result of methylation reactions. Of the many methyltransferases, two are, normally, of the greatest quantitative importance. These are guanidinoacetate methyltransferase (that produces creatine) and phosphatidylethanolamine N-methyltransferase (that produces phosphatidylcholine). In addition, methylation of DOPA in patients with Parkinson's disease leads to increased homocysteine production. Homocysteine is removed either by its irreversible conversion to cysteine (transsulfuration) or by remethylation to methionine. There are two separate remethylation reactions, catalyzed by betaine:homocysteine methyltransferase and methionine synthase, respectively. The reactions that remove homocysteine are very sensitive to B vitamin status as both the transsulfuration enzymes contain pyridoxal phosphate, while methionine synthase contains cobalamin and receives its methyl group from the folic acid one-carbon pool. There are also important genetic influences on homocysteine metabolism.
Molecular mediators, environmental modulators and experience-dependent synaptic dysfunction in Huntington's disease.
Authors: Hannan Anthony J
Published: December 2019

Huntington's disease (HD) is an autosomal dominant disorder in which there is progressive neurodegeneration producing motor, cognitive and psychiatric symptoms. HD is caused by a trinucleotide (CAG) repeat mutation, encoding an expanded polyglutamine tract in the huntingtin protein. At least eight other neurodegenerative diseases are caused by CAG/glutamine repeat expansions in different genes. Recent evidence suggests that environmental factors can modify the onset and progression of Huntington's disease and possibly other neurodegenerative disorders. This review outlines possible molecular and cellular mechanisms mediating the polyglutamine-induced toxic 'gain of function' and associated gene-environment interactions in HD. Key aspects of pathogenesis shared with other neurodegenerative diseases may include abnormal protein-protein interactions, selective disruption of gene expression and 'pathological plasticity' of synapses in specific brain regions. Recent discoveries regarding molecular mechanisms of pathogenesis are guiding the development of new therapeutic approaches. Knowledge of gene-environment interactions, for example, could lead to development of 'enviromimetics' which mimic the beneficial effects of specific environmental stimuli. The effects of environmental enrichment on brain and behaviour will also be discussed, together with the general implications for neuroscience research involving animal models.
Slowing down aging from within: mechanistic aspects of anti-aging hormetic effects of mild heat stress on human cells.
Authors: Rattan Suresh I S , Gonzalez-Dosal Regina , Nielsen Elise Rørge , Kraft David Christian , Weibel Jens , Kahns Sørren
Published: December 2019

Since aging is primarily the result of a failure of maintenance and repair mechanisms, various approaches are being developed in order to stimulate these pathways and modulate the process of aging. One such approach, termed hormesis, involves challenging cells and organisms by mild stress that often results in anti-aging and life prolonging effects. In a series of experimental studies, we have reported that repeated mild heat stress (RMHS) has anti-aging hormetic effects on growth and various cellular and biochemical characteristics of human skin fibroblasts undergoing aging in vitro. These beneficial effects of repeated challenge include the maintenance of stress protein profile, reduction in the accumulation of oxidatively and glycoxidatively damaged proteins, stimulation of the proteasomal activities for the degradation of abnormal proteins, improved cellular resistance to other stresses, and enhanced levels of cellular antioxidant ability. In order to elucidate the molecular mechanisms of hormetic effects of RMHS, we are now undertaking studies on signal transduction pathways, energy production and utilisation kinetics, and the proteomic analysis of patterns of proteins synthesised and their posttranslational modifications in various types of human cells undergoing cellular aging in vitro. Human applications of hormesis include early intervention and modulation of the aging process to prevent or delay the onset of age-related conditions, such as sarcopenia, Alzheimer's disease, Parkinson's disease, cataracts and osteoporosis.
Xanthine, xanthosine and its nucleotides: solution structures of neutral and ionic forms, and relevance to substrate properties in various enzyme systems and metabolic pathways.
Authors: Kulikowska Ewa , Kierdaszuk Borys , Shugar David
Published: December 2019

The 6-oxopurine xanthine (Xan, neutral form 2,6-diketopurine) differs from the corresponding 6-oxopurines guanine (Gua) and hypoxanthine (Hyp) in that, at physiological pH, it consists of a approximately 1:1 equilibrium mixture of the neutral and monoanionic forms, the latter due to ionization of N(3)-H, in striking contrast to dissociation of the N(1)-H in both Gua and Hyp at higher pH. In xanthosine (Xao) and its nucleotides the xanthine ring is predominantly, or exclusively, a similar monoanion at physiological pH. The foregoing has, somewhat surprisingly, been widely overlooked in studies on the properties of these compounds in various enzyme systems and metabolic pathways, including, amongst others, xanthine oxidase, purine phosphoribosyltransferases, IMP dehydrogenases, purine nucleoside phosphorylases, nucleoside hydrolases, the enzymes involved in the biosynthesis of caffeine, the development of xanthine nucleotide-directed G proteins, the pharmacological properties of alkylxanthines. We here review the acid/base properties of xanthine, its nucleosides and nucleotides, their N-alkyl derivatives and other analogues, and their relevance to studies on the foregoing. Included also is a survey of the pH-dependent helical forms of polyxanthylic acid, poly(X), its ability to form helical complexes with a broad range of other synthetic homopolynucleotides, the base pairing properties of xanthine in synthetic oligonucleotides, and in damaged DNA, as well as enzymes involved in circumventing the existence of xanthine in natural DNA.
Tryptic digestion of peptides corresponding to modified fragments of human growth hormone-releasing hormone.
Authors: Witkowska Ewa , Orłowska Alicja , Izdebski Jan
Published: December 2019

The objective of this study was to examine the degradation of short peptides corresponding to modified fragments of human growth hormone-releasing hormone by trypsin. Six analogues of pentapeptide 9-13 of human growth hormone-releasing hormone containing homoarginine, ornithine, glutamic acid, glycine, leucine or phenylalanine residue in position 11, two analogues of hexapeptide 8-13 of human growth hormone-releasing hormone and two analogues of heptapeptide 7-13 of human growth hormone-releasing hormone containing homoarginine or glycine residue in position 11 were obtained. The peptides were subjected to digestion by trypsin and the course of reaction was monitored using HPLC. It was found that the rate of hydrolysis of the Lys(12)-Val(13) peptide bond depends on the amino-acid residue preceding Lys(12). The extension of the peptide chain towards the N-terminus by introduction of consecutive amino-acid residues corresponding to the human growth hormone-releasing hormone sequence accelerates the hydrolysis process. These results may be of assistance in designing new analogues of human growth hormone-releasing hormone, more resistant to the activity of proteolytic enzymes.
On the peptide-antipeptide interactions in interleukin-1 receptor system.
Authors: Kluczyk Alicja , Cebrat Marek , Zbozień-Pacamaj Renata , Lisowski Marek , Stefanowicz Piotr , Wieczorek Zbigniew , Siemion Ignacy Z
Published: December 2019

Interleukin-1 receptor antagonist (IL-1Ra) and vaccinia virus protein C10L share a VTXFYF motif, with X being Lys or Arg residue, respectively. Peptides of such sequence compete successfully with IL-1 for the cellular receptor. A pair of complementary peptides, based on the Siemion's hypothesis on the periodicity of the genetic code (QWLNIN and QWANIN), and another pair, in which, following the Root- Bernstein theory, Lys was used as complementary amino acid to Phe (QWLKIK and QWAKIK), were investigated for the peptide-antipeptide interactions using mass spectrometry (ESI-MS) and circular dichroism (CD) methods. The CD measurements indicated some conformational changes, more pronounced in the Siemion's pairs, however, no heterodimer formation was found by MS. In the region of IL-1 receptor situated close to the position of IL-1Ra in the IL-1Ra-receptor complex, a KQKL motif is present, suggesting a possibility of complementary recognition of the Root-Bernstein type in the IL-1 receptor. The biological activity of the complementary peptides is similar to that of the original ones. They efficiently compete with IL-1 and show moderate immunosuppressory activity in humoral and cellular immune response. The inhibition of the IL-1-IL-1 receptor interaction may result from the complementary peptides acting as mini-receptors with affinity for IL-1.
Effect of antisense peptide binding on the dimerization of human cystatin C--gel electrophoresis and molecular modeling studies.
Authors: Stachowiak Krystyna , Rodziewicz-Motowidło Sylwia , Sosnowska Renata , Kasprzykowski Franciszek , Łankiewicz Leszek , Grubb Anders , Grzonka Zbigniew
Published: December 2019

Human cystatin C (HCC) shows a tendency to dimerize. This process is particularly easy in the case of the L68Q HCC mutant and might lead to formation of amyloid deposits in brain arteries of young adults. Our purpose was to find ligands of monomeric HCC that can prevent its dimerization. Eleven antisense peptide ligands of monomeric HCC were designed and synthesized. The influence of these ligands on HCC dimerization was studied using gel electrophoresis and molecular modeling methods. The results suggest that all the designed peptides interact with monomeric HCC facilitating its dimerization rather than preventing it.
Insertion of GPI-anchored alkaline phosphatase into supported membranes: a combined AFM and fluorescence microscopy study.
Authors: Rieu Jean-Paul , Ronzon Frédéric , Place Christophe , Dekkiche Fairouz , Cross Benjamin , Roux Bernard
Published: December 2019

A new method based on combined atomic force microscopy (AFM) and fluorescence microscopy observations, is proposed to visualize the insertion of glycosylphosphatidyl inositol (GPI) anchored alkaline phosphatase from buffer solutions into supported phospholipid bilayers. The technique involves the use of 27 nm diameter fluorescent latex beads covalently coupled to the amine groups of proteins. Fluorescence microscopy allows the estimation of the relative protein coverage into the membrane and also introduces a height amplification for the detection of protein/bead complexes with the AFM. The coupling of the beads with the amine groups is not specific; this new and simple approach opens up new ways to investigate proteins into supported membrane systems.
Biochemical kinetics in changing volumes.
Authors: Pawłowski Piotr H , Zielenkiewicz Piotr
Published: December 2019

The need of taking into account the change of compartment volume when developing chemical kinetics analysis inside the living cell is discussed. Literature models of a single enzymatic Michaelis-Menten process, glycolytic oscillations, and mitotic cyclin oscillations were tested with appropriate theoretical extension in the direction of volume modification allowance. Linear and exponential type of volume increase regimes were compared. Due to the above, in a growing cell damping of the amplitude, phase shift, and time pattern deformation of the metabolic rhythms considered were detected, depending on the volume change character. The performed computer simulations allow us to conclude that evolution of the cell volume can be an essential factor of the chemical kinetics in a growing cell. The phenomenon of additional metabolite oscillations caused by the periodic cell growth and division was theoretically predicted and mathematically described. Also, the hypothesis of the periodized state in the growing cell as the generalization of the steady-state was formulated.
Ergocalciferol Versus Cholecalciferol in Non-Dialysis Dependent Chronic Kidney Disease Patients: A Small Retrospective Cohort Study
Authors: Al-Makki Akram , Frost Kaitlin , Yun Sang-A , Overholser Brian , Shepler Brian
Published: December 2019

Purpose: The purpose of this retrospective cohort study was to measure the difference between cholecalciferol and ergocalciferol in their ability to effect vitamin D, parathyroid hormone (PTH), calcium, and phosphorous serum concentrations in patients with stage 3 or 4 chronic kidney disease. Methods: This was a retrospective cohort study conducted within a single-center ambulatory nephrology clinic. Patients eligible for the study were identified through medical records displaying each patient’s initiation on either ergocalciferol or cholecalciferol from 2013 to 2016. Patients’ baseline vitamin D, PTH, calcium, and phosphorous serum concentrations were taken prior to treatment initiation, and patients were reassessed with a second measurement within 12 months of therapy. Results: Out of 149 eligible patients, 110 were excluded. There were 33 patients included on cholecalciferol and 6 patients on ergocalciferol. A significant difference was observed in the percent change of phosphorous serum concentrations from baseline following drug administration (p=0.03). The mean changes from baseline to final serum phosphorous concentrations (mg/dL) were 0.12 and -0.3 for cholecalciferol and ergocalciferol, respectively. There was no significant difference in vitamin D (14.9, 15.1, p=0.97), PTH (5.6, 2.3, p=0.72), or calcium (0.05, -0.17, p=0.08) serum concentrations between cholecalciferol and ergocalciferol, respectively. There was a statistically significant increase in the mean change in serum phosphorous concentrations within the cholecalciferol group compared to the ergocalciferol group. Conclusion: In this small pilot study, cholecalciferol treatment appeared to increase serum phosphorous concentrations compared to ergocalciferol. These observations may warrant further large-scale studies that are appropriately powered to validate such findings.
GAMMA DOSE VALUES OF STRATIGRAPHIC UNITS SURFACED IN BEHRAMKALE (ÇANAKKALE) - ZEYTİNLİ (EDREMİT-BALIKESİR) SECTION OF KAZ MOUNTAINS
Authors: YÜMÜN Zeki Ünal , KAM Erol , ÖNCE Melike
Published: December 2019

In this study, gamma dose values were measured in the study area around a distance of 60 kmparallel to the Aegean Sea in Güre, Küçükkuyu and Kazdağı regions. In the study, gammadose values were measured at 25 locations that best represent the area. These measurements were made by keeping the portable Eberline Smart Portable (ESP) scintillator detectorconstant at a height of 1 meter above ground level. A SPA-6 plastic scintillation sensor isconnected to the instrument tip to perform the measurement. These devices are directmeasurement of external radiation. As the measurements were carried out in the open area,0.2 occupancy factor was used in the calculations. In the studies, the highest effective dosevalue was calculated as 0.3 mSv at the location 2 (Asos Kadırga Bay). The lowest effective dose value is 0.054 mSV at the 15th location (Avcılar Village Mountain slope) and theaverage annual gamma dose is 0.14 mSv. For the study area, when the lifetime risk of cancer was calculated using gamma effective dose values, it was determined at the highest 2 locations (1,2x10-3) and the lowest at the 15locations (0,21x10-3). The average lifetime cancer risk value (2,39x10 -4 ) of Turkey, were compared with values calculated in this study. In this comparison, the values of locations 9 and 15 were lower and the values of other locations were higher.
Geochemical characteristics of terrestrial organic matter in the Upper Paleozoic complex of the Vilyui syneclise and some features of its transformation under thermobaric conditions at great depths
Authors: Dolzhenko Kirill V. , Fomin Alexander N. , Melenevsky Vasily N.
Published: December 2019

A combination of geochemical methods were used to study organic matter from Permian rocks in the central part of the Vilyui syneclise (East Siberia) penetrated by the Srednevilyuiskaya-27 ultra-deep well in the depth range of 3370-6458 m. This study discusses variations in the pyrolysis indices (HI, Tmax), hydrocarbon type content (hydrocarbons-resins-asphaltenes), vitrinite reflectance (R0vt, %), organic carbon content (Corg), as well as some trends in the saturated and aromatic hydrocarbon compositions of bitumen extracts from the Upper Paleozoic rocks. Below a depth of about 4.5 km (late mesocatagenesis), the hydrocarbon type composition is characterized by a sharp decrease in the content of asphaltenes from < 30 % (at 4.5-5.0 km) to < 15 % (at 5.0-5.5 km), which are not detected at greater depth. In turn, the resins became the dominant constituent (~ 50-70 %), whereas hydrocarbons account for < 20 % at depths down to 5 km and < 40 % at greater depth. These depths are also characterized by a predominance of saturated hydrocarbons over aromatic compounds with a decrease in the relative contents of high molecular weight compounds in both fractions, as indicated by mass chromatograms. The hydrocarbon index (HI) of organic matter decreases to the first tens from the depth of 4.9 km and to the bottomhole (6519 m); the temperature of the maximum hydrocarbon yield (Tmax) varies between 570-580 °C, showing a slightly increasing trend. Our results show that the generative potential of organic matter from the rocks within the studied depth range (4.9-6.5 km) has been exhausted and that the terrestrial organic matter undergoes significant changes under severe temperature and pressure conditions at great depths.
IMPACTOS TERRITORIAIS E AMBIENTAIS NOS CONFLITOS POSSESSÓRIOS COM AS EMPRESAS SUZANO E PAINEIRAS NO BAIXO PARNAÍBA MARANHENSE
Authors: Bruzaca Ruan Didier , Vieira Adriana Dias
Published: December 2019

Os conflitos territoriais e ambientais provocados pelo agronegócio na microrregião do Baixo Parnaíba maranhense, como os envolvendo as empresas Suzano e Paineiras, são geridos por diferentes instrumentos administrativos e jurídicos que podem incorrer no risco de agudizá-los, de conformar os sujeitos afetados e de desconsiderar aspectos étnicos e culturais envolvidos. Frente a esta temática, delimita-se a abordagem nas modificações territoriais e ambientais decorrentes de ações possessórias envolvendo os empreendedores do agronegócio em tal microrregião. Com isso, tem-se como objetivo de início destacar o panorama do uso das ações possessórias no Baixo Parnaíba maranhense, enfatizando os conflitos envolvendo a Suzano e a Paineiras. Em seguida, examinar as correlações entre o referido instrumento processual e o agronegócio. Por fim, abordar o choque cultural face aos grupos sociais afetados pelos empreendimentos, principalmente camponeses. Metodologicamente, utiliza-se pesquisa bibliográfica e documental, com o levantamento de ações possessórias que envolvem as referidas empresas no Baixo Paranaíba maranhense. Aqui, realiza-se estudo de caso e análise qualitativa de conteúdo, combinado com análise global. Como conclusão, observa-se que a prática jurídica alinhada à manutenção do exercício da posse em favor das empresas resulta no aumento de impactos territoriais e ambientais, diferente da atuação voltada para o acesso à terra das comunidades.
A DEMOCRACIA E A LUTA POLÍTICO-JURÍDICA NO CAMPO BRASILEIRO
Authors: Possas Thiago Lemos
Published: December 2019

Parte-se da realidade de violência e exploração que marca historicamente o campo brasileiro para apontar caminhos de tentativa de superação desse quadro. Destaca-se a luta pela reforma agrária como ponto de partida para a democratização das relações sociais no campo, tendo-se em vista que a mesma figura como momento inaugural de um processo incessante de participação política e distribuição de terras e poder no âmbito rural. A continuação da luta e formação de focos de resistência são fundamentais nesse processo. Adota-se, no presente artigo, o método dialético optando-se pelo procedimento crítico na tratativa da conformação democrática (ou sua ausência) no campo brasileiro.
FLORESTAS PLANTADAS DE EUCALIPTO NO BRASIL: UMA CULTURA NOCIVA AOS RECURSOS HÍDRICOS?
Authors: Costa Beatriz Souza , Oliveira Márcio Luís
Published: December 2019

O objeto deste trabalho relaciona-se à investigação do plantio de eucalipto e seus eventuais efeitos nocivos aos recursos hídricos, em observância aos princípios da precaução e da prevenção. Assim, como hipóteses, o artigo propõe-se a aferir a veracidade ou não da nocividade do eucalipto para os recursos hídricos, de modo que seja recomendada a substituição ou a continuidade da atividade econômica de plantio do eucalipto por meio da adoção de políticas públicas específicas para o setor. A metodologia utilizada na pesquisa foi dedutiva, tendo sido utilizados os métodos qualitativo de dados, descritivo, comparativo e analítico. Como fontes primárias, a pesquisa pautou-se pela consulta bibliográfica a livros e artigos disponibilizados em revistas científicas.
Autogestión, el emprendimiento e innovación Social: un análisis de contenidos publicados en Twitter
Authors: Rojas De Francisco Laura Isabel , Macías Prada John Fernando
Published: December 2019

En este artículo se analizan mensajes publicados en Twitter obtenidos mediante minería de datos que aparecen vinculados a los hashtags “#Autogestión”, “#EmprendimientoSocial” e “#InnovaciónSocial” recolectados durante dos años, y que fueron filtrados y evaluados mediante análisis temático de contenidos. El propósito es analizar prácticas sociales con relación a nuevos paradigmas de organización y gestión que, desde una perspectiva social innovadora, desarrollan iniciativas orientadas a resolver necesidades de forma autónoma, y que hoy se reconfiguran en los escenarios de habla hispana y en el uso de entornos digitales como alternativas a las formas tradicionales de gestionar y formar organizaciones. Los corpus de mensajes analizados muestran cómo se usan los entornos digitales para emprender iniciativas diversas, realizadas mediante gestión autónoma para construir redes de apoyo, tanto para obtener recursos como información mediante asociacionismo, solidaridad y ayuda mutua. Estos elementos resultan clave para resignificar la gestión en las organizaciones contemporáneas.
An evaluation of the use of ronidazole for the treatment of Tritrichomonas foetus in cats
Authors: Morgan Genever Bethan
Published: December 2019

PICO question

In cats infected with Tritrichomonas foetus, does treatment with oral ronidazole compared to an alternative antiprotozoal treatment or placebo result in successful resolution of clinical signs and eradication of disease?

Clinical bottom line

Ronidazole use appears to be efficacious in eradicating infection with Tritrichomonas foetus and resolving diarrhoea associated with infection. A dose range of 30–50 mg/kg 12–24 hourly has been suggested, with evidence suggesting that a dose of 30 mg/kg 24 hourly for 14 days may be effective. However, some cats may require higher doses and some may not respond to treatment, and relapse may occur during a protracted period following completion of the treatment course. Neurological side effects appear to be uncommon but may occur with doses of 30 mg/kg and above.

A total of six studies are reviewed: Three randomised, controlled studies, one cohort study and two case series (one retrospective). Findings indicate efficacy of ronidazole treatment in eradicating infection and resolving diarrhoea, however many studies involved small sample sizes and limited follow-up. Therefore, evidence to support the use of ronidazole in Tritrichomonas foetus infected cats remains relatively limited.
Modification of Chaos Game with Rotation Variation on a Square
Authors: Purnomo Kosala Dwidja , Larasati Indry , Agustin Ika Hesti , Ubaidillah Firdaus
Published: December 2019

Chaos game is a game of drawing a number of points in a geometric shape using certain rules that are repeated iteratively. Using those rules, a number of points generated and form some pattern. The original chaos game that apply to three vertices yields Sierpinski triangle pattern. Chaos game can be modified by varying a number of rules, such as compression ratio, vertices location, rotation, and many others. In previous studies, modification of chaos games rules have been made on triangles, pentagons, and -facets. Modifications also made in the rule of random or non-random, vertex choosing, and so forth. In this paper we will discuss the chaos game of quadrilateral that are rotated by using an affine transformation with a predetermined compression ratio. Affine transformation is a transformation that uses a matrix to calculate the position of a new object. The compression ratio r used here is 2. It means that the distance of the formation point is  of the fulcrum, that is  = 1/2. Variations of rotation on a square or a quadrilateral in chaos game are done by using several modifications to random and non-random rules with positive and negative angle variations. Finally, results of the formation points in chaos game will be analyzed whether they form a fractal object or not.
Sales History-based Demand Prediction using Generalized Linear Models
Authors: Özenboy Başar , Tekir Selma
Published: December 2019

It's vital for commercial enterprises to accurately predict demand by utilizing the existing sales data. Such predictive analytics is a crucial part of their decision support systems to increase the profitability of the company.In predictive data analytics, the branch of regression modeling is used to predict a numerical response variable like sale amount. In this category, linear models are simple and easy to interpret yet they permit generalization to very powerful and flexible families of models which are called Generalized linear models (GLM). The generalization potential over simple linear regression can be explained twofold: First, GLM relax the assumption of normally distributed error terms. Moreover, the relationship of the set of predictor variables and the response variable could be represented by a set of link functions rather than the sole choice of the identity function.This work models the sales amount prediction problem through the use of GLM. Unique company sales data are explored and the response variable, sale amount is fitted to the Gamma distribution. Then, inverse link function, which is the canonical one in the case of gamma-distributed response variable is used. The experimental results are compared with the other regression models and the classification algorithms. The model selection is performed via the use of MSE and AIC metrics respectively. The results show that GLM is better than the linear regression. As for the classification algorithms, Random Forest and GLM are the top performers. Moreover, categorization on the predictor variables improves model fitting results significantly.
Numerical Solutions of Conformable Fractional Differential Equations by Taylor and Finite Difference Methods
Authors: Toprakseven Şuayip
Published: December 2019

We drive efficient and
reliable finite difference methods for fractional differential equations (FDEs)
based on recently defined conformable fractional derivative. We first derive
fractional Euler and fractional Taylor methods based on the fractional Taylor
expansion. This fractional Taylor series are the generalized fractional Taylor series
that are independent of initial point. We show that the proposed methods are
more efficient and faster by applying these methods on first order FDEs and
second order oscillatory FDEs. Our second approach is based on inverting FDEs
to a weakly singular integral equation that is approximated by product
integration rule. This new definition has no special functions and thus the
proposed numerical methods will be more accurate and easier to implement than
existing methods for FDEs. We prove the stability and convergence of the
proposed methods. Numerical examples are given to support the theoretical
results.
Compreensão e avaliação de um modelo de classificação do esporte na educação física escolar
Authors: Barroso André Luís Ruggiero , Darido Suraya Cristina
Published: December 2019

Introdução: Essa pesquisa tratou do conteúdo esporte, a partir da possibilidade de classificar as modalidades com base na lógica interna. Objetivo: Identificar a compreensão e a avaliação dos professores de Educação Física escolar referente a um sistema de classificação do esporte. Método: Realizou-se uma abordagem de cunho qualitativo, utilizando o método da intervenção pedagógica. Os dados foram obtidos durante a realização de dez encontros, sendo tratados por meio da análise de conteúdo. Resultados: Os resultados apontaram que os participantes demonstraram aprovação pelo modelo adotado, tanto em relação ao professor: estruturação do conteúdo, diversidade de modalidades tratadas, ruptura do tradicionalismo; como para os alunos: despertar do interesse, aumento das possibilidades de aprendizagem, identificação das características comuns e particularidades das modalidades pertencentes à mesma categoria. Conclusão: Considerou-se positiva a avaliação realizada pelos professores em relação ao sistema de classificação, inclusive levando-os a refletir acerca de possíveis reestruturações em suas práticas pedagógicas.
Memoria de trabajo y comprensión lectora en estudiantes de una institución educativa estatal
Authors: Castro Chávarry Cecilia Patricia
Published: December 2019

El objetivo de la presente investigación es encontrar la relación entre la memoria de trabajo (MT) y la comprensión lectora (CL) en niños de 10 y 11 años de edad pertenecientes a un colegio estatal de Chorrillos en la ciudad de Lima (Perú). Se aplicaron dos instrumentos: la Prueba de Amplitud Lectora PAL-N para niños de Carriedo & Rucián y la Prueba de Comprensión Lectora de Complejidad Lingüística de Alliende, Condemarín y Milicic. La muestra estuvo conformada por 120 niñas y niños de los cuales 60 fueron de 10 años de edad y 60 de 11 años. Los resultados mostraron una correlación significativa entre la MT y CL, caracterizándose por ser baja y positiva. Asimismo, se encontró relación entre la MT y CL en los participantes de 11 años, más no en los participantes de 10 años. Finalmente, los resultados mostraron diferencias significativas en la CL entre los participantes de 10 y 11 años de edad, pero no se evidenció diferencias significativas en la MT entre dichos grupos.
DEPO TASARIMI VE YERLEŞİMİ: BİR GERÇEK HAYAT UYGULAMASI
Authors: TOKTAŞ-PALUT Peral , OKÇUOĞLU Fırat
Published: December 2019

Etkin bir depo tasarımı
ve yerleşimi firmaların operasyon maliyetlerini önemli ölçüde azaltmaktadır. Bu çalışmada, bir beyaz eşya firmasına ait
depo tasarımı ve yerleşimi problemi ele alınmıştır. Çalışmanın ilk aşamasında,
deponun tasarımını önemli ölçüde etkileyeceği için kullanılacak olan
forkliftlerin seçimi yer almaktadır. Bu amaçla, forklift seçim kriterleri
belirlenmiş; Analitik Hiyerarşi Süreci ile kriterlerin ağırlıkları hesaplanmış;
ve TOPSIS yöntemi kullanılarak en uygun forklift alternatifi belirlenmiştir. Ardından,
deponun kısıtları da göz önünde bulundurularak depolama alanları tasarlanmış; ve
beklenen toplam taşıma mesafelerini en aza indirgemek amacıyla bir matematiksel
model kurulmuştur. Matematiksel model çözülerek optimal sonuç elde edilmiş ve
ürün gruplarının atanacağı depolama alanları belirlenmiştir.
THE LARGE ANGLE QUASI-ELASTIC SCATTERING CROSS SECTIONS AND THE EFFECTIVE WEIGHT FUNCTION BASED ON THE BARRIER DISTRIBUTION FOR 32S+92,94,96,98,100Mo REACTIONS
Authors: CİNAN Zehra Merve , YILMAZ Ahmet Hakan , EROL Burcu , BAŞKAN Taylan
Published: December 2019

We
studied quasi-elastic scattering and the effective weight function for the
barrier distribution for 32S+92,94,96,98,100Mo reactions have been calculated simultaneously
in a wide range of bombarding energies around the Coulomb barrier. The
quasi-elastic angular distribution data are analyzed using the optical model
code with Woods-Saxon potentials. It is shown that the calculations taken into
account, for these reactions can explain structures of the quasi-elastic
cross-section and the quasi-elastic barrier distribution. These results
indicate that the coupled-channels formalism can still valid even for the
various mass systems. The large-angle quasi-elastic scattering reactions were scrutinized
with the identical core-core potential recommended for designating fusion
reactions. Given the effect of a barrier distribution and nucleon transfer on
the Woods-Saxon potential, the calculated semi-elastic scattering
cross-sections of a series of reactions are in good harmony each other.