bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel uses of three-parameter logistic models and first-derivative models for the Coronavirus Disease (COVID-19) epidemic in the United States, in three distinct scenarios
Authors: Samuel Bishoy T.
Published: August 2020

Background: Forecasting the current coronavirus disease (COVID-19) epidemic in the United States necessitates novel mathematical models for accurate predictions. This paper examines novel uses of three-parameter logistic models and first-derivative models through three distinct scenarios that have not been examined in the literature as of July 14, 2020.Methods: Using publicly available data, statistical software was used to conduct a non-linear least-squares estimate to generate a three-parameter logistic model, with a subsequently generated first-derivative model. In the first scenario a logistic model was used to examine the natural log of COVID-19 cases as the dependent variable (versus day number), on July 11 and May 1. Independent t-test analyses were used to test comparative coefficient differences across models. In the second scenario, a first-derivative model was derived from a base three-parameter logistic model for April 27, examining time to peak mortality and decrease in case fatality rate. In the third scenario, a first-derivative model of mortality through July 11 as the dependent variable, versus confirmed cases, was generated to look at case fatality rate relative to increasing cases.Results: All models generated were statistically significant with R2 > 99%. The logistic models in the first scenario best predicted time to growth deceleration in the natural log of cases in the U.S. (slowing of exponential growth), estimated at March 11, 2020. For the May 1 data, independent t-test analyses of comparative coefficients across models were useful to track improvements from implemented public health measures. The first-derivative model in the second scenario on April 27, when the epidemic was more controlled, showed peak mortality around April 12-13, with a case fatality rate of < 1,000 deaths and trending down. The first-derivative model in the third scenario estimated a near-zero case fatality rate to occur at 4 million confirmed cases. It has not been affected by fluctuations in mortality from June 29 through July 11.Conclusion: Three-parameter logistic models and first-derivative models have utility in predicting time to growth deceleration, and case fatality rates relative to cases. They can objectively assess improvements of implemented epidemiologic measures and have applicable public health safety implications.
Inhibition of Rac1 Attenuates Radiation-Induced Lung Injury while Sensitizes Lung Tumor to Radiotherapy
Authors: An Ni , Li Zhenjie , Yan Xiaodi , Zhao Hainan , Yang Yajie , Liu Ruling , Yang Yanyong , Gao Fu , Li Bailong , Cai Jianming , Liu Hu , Yuan Hongbin
Published: August 2020

Backgrounds: There is still little progress in the effective treatment of radiation-induced lung injury (RILI), a key dose-limiting factor for thoracic radiotherapy. Ras-related C3 botulinum toxin substrate1, Rac1, is a small guanosine triphosphatase involved in various mechanisms of radiation-induced damage and is over-expressed/mutated in various tumors. The gain-of-function mutation of Rac1 mediates tumor cells’ resistance to radiotherapy. Therefore, inhibiting Rac1 has the potential of protecting normal tissues from radiation-induced injury, and at the same time, sensitizing tumor to radiation therapy, which makes it a promising ideal target for radiation protection. To investigate the protective effects and mechanisms of Rac1 inhibition on RILI, and explore the possible mechanisms that mediate the differential effects of Rac1 inhibition on normal lung tissue and tumor cells.Methods: 60Co radioactive source was used for ionizing radiation (IR). RILI mouse model was constructed. Influence of Rac1 inhibition which was achieved by Rac1-specific inhibitor, NSC23766, on RILI were studied by H & E and Masson staining, and immunohistochemical staining of vimentin, TGF-βand γ-H2AX. Normal mouse lung epithelial cell line, MLE-12, and mouse lung cancer cell line, LLC, were used to study the effects of Rac1 inhibition on the cellular level. RNA-seq analysis was used for screening differential gene expression caused by Rac1 knockdown. The molecular mechanisms of Rac1 inhibition were studied at the cellular level. Subcutaneous tumor-bearing nude mouse model and orthotopic lung tumor-bearing mouse model were constructed to verify the bidirectional effects of Rac1 inhibition in vivo. Results: RILI of mouse was alleviated by intraperitoneal injection of NSC23766. Rac1 inhibition/knockdown reduced the radiation-induced damage of MLE-12 while aggravated that of LLC. Rac1 translocated from cytoplasm to nucleus after radiation. Tumor protein p53-inducible nuclear protein 1, Trp53inp1, was down-regulated by Rac1 knockdown. In vivo study further proved the differential effects of Rac1 inhibition. Rac1 was over-expressed and mutated in LLC cells, and the expression level of Trp53inp1 significantly lower, compared with that of MLE-12.Conclusion: Rac1 inhibition reduced the radiation-induced damage of normal lung epithelial cells, thereby alleviating RILI of mouse. These effects were partially mediated by down-regulating the expression of Trp53inp1. However, Rac1 inhibition significantly increased the sensitivity of LLC to radiation damage and inhibited its growth. The over-expression and mutation of Rac1, and the significant low expression of Trp53inp1 in LLC, may be the fundamental reasons mediating the differential effects of Rac1 inhibition.
Three-dimensional Numerical Study on the Metal Rotating Spray Transfer Process of High-current GMAW
Authors: Xiao Lei , Fan Ding , Huang Jiankang
Published: August 2020

Gas metal arc welding (GMAW) is one of the most widely used processes in automated welding technologies. Its efficiency relies on the travel speed and wire melting rate. Increasing the welding current is the most effective way to improve them. However, the welding quality will decrease because of the unstable metal rotating spray transfer in the high-current GMAW which will aggravate the welding spatters and instability. To study the high-current metal transfer mechanism and then propose schemes of improvements and controls, a three-dimensional numerical model based on the volume-of-fluid (VOF) method is typically preferred. Unfortunately, the rotating spray transfer is extremely complicated, therefore the research community has focused on simplified models without considering the energy conservation to make analysis manageable for the unstable metal transfer process. Using our created model, the metal transfer of high-current GMAW with shielding gas of different conductivities has been studied by analyzing acting forces and fluid flows in the metal liquid column, especially for the contributions of the self-induced electromagnetic force, equivalent volume force of the capillary pressure of the surface tension (Named surface tension force in this work), static arc pressure. It is found that the unbalanced electromagnetic force greatly promotes the metal rotating motion in 500A MIG with pure argon shielding gas and it pushes the metal liquid column to rotate. Considering the arc constricting effect in active shielding gas by simply changing the arc conductivity, it is found that the metal liquid column no longer rotates, it turns to swing since the unbalanced electromagnetic force is large enough to break the rotating motion. The calculated results of the metal liquid column deflected angle and rotating/swing frequency agree well with the experiment of high-speed camera observations.
Preparedness for COVID-19 by Primary Healthcare Workers in Rivers State, Nigeria: Facility Cross-sectional Survey
Authors: Edet Clement Kevin , Wegbom Anthony Ike , Kiri Prof. Victor Alangibi
Published: August 2020

Introduction: The primary healthcare workers (PHCWs) face a higher risk of infection associated with their occupation, due to inadequate supplies of personal protective equipment (PPE), inappropriate use of PPEs, and insufficient knowledge on infection prevention and control. Therefore, this study aimed to assess the preparedness for COVID-19 by PHCWs in Rivers State, Nigeria. Method: A cross-sectional survey was conducted involving the healthcare workers at the public primary healthcare facilities across the 23 local government areas (LGAs) of Rivers State, Nigeria. The descriptive statistics of mean ± standard deviation and percentage were used to present quantitative and categorical variables respectively. The preparedness for COVID-19 was measured by knowledge, attitude and preventive practices (KAP) towards the disease. The association between the KAP and demographic characteristics was tested with the Chi-square test, while the associations existing among the KAP constituents were evaluated with the Pearson correlation coefficient. Statistical significance was evaluated at P<0.05. Results: Out of 460 questionnaires distributed, 412 respondents participated in the survey, indicating a response rate of 89.6%. The proportion of respondents with good scores in knowledge, attitude, and COVID-19 related practices was 86.4% (10.66 ± 2.40), 85.0% (8.28 ± 1.94), and 97.3% (8.34 ± 1.39) respectively. Gender, occupation, and years of experience were associated with knowledge, while years of experience and marital status were associated with attitude and preventive practices. Knowledge score also had significant positive linear associations with both attitudes and practices ( scores toward COVID-19. Conclusion: Our findings revealed the level of PHCWs preparedness to fight COVID-19 in Rivers State. We suggest that public health education programs on infection prevention and control should be sustained. Furthermore, training should be tailored to meet the peculiarities of the different categories of healthcare workers and years of practice.
Analysis of Factors Influencing Adoption of Human Resource Practices by Small and Medium Scale Enterprises in Nigeria
Authors: Rabiu Rukayat Oloruntoyin , Olanipekun Wahid Damilola , Bamidele Ayodeji Gbenga
Published: July 2020

In the XXI century, one of the most valuable resources of any organization is human capital. The effectiveness of the organization and the use of other resources depend on the formation quality and the use of the human capital. Today, many factors affect small and medium scale enterprises that lead to their rapid bankruptcy and liquidation, significant staff turnover, and reduced productivity. Under these conditions, attracting and retaining highly qualified personnel as the primary determinant of economic development and growth of small and medium scale enterprises is significantly relevant. Minimizing the negative impact of external and internal factors made by small and medium scale businesses requires recognition of the value of the human resources in improving the enterprise’s competitiveness and the effective management tools implementation. The study identifies the main factors influencing the implementation of human resource management practices in small and medium scale enterprises in Kwara, Nigeria. Methodological tools of this study are methods of analysis and synthesis, comparative and regression analysis. The study covers 200 small and medium scale enterprises in the Kwara Central Senatorial District and registered in the National Association of Small and Medium Enterprises (NASME). The factors influencing the use of human resources by small and medium scale enterprises in the article are studied in the following logical sequence: using a structured questionnaire developed in the form of the Rensis Likert scale, an array of primary data is forme. The hypothesis (at the level of 5% of weight) regarding the relationship between the efficiency indicators and human resources management policy is tested using multiple regression analysis with statistical software STATA 11.0. The results of the survey are analyzed, summarized, and interpreted using descriptive statistical methods. The results of multiple regression analyses confirm a statistically significant relationship between the analyzed indicators (p = 0.000 and R2 = 0.8128). The study shows a significant impact of financial security of the organization (β = 0.76; t = 8.63; p) and its size (β = 0.46; t = 4.66; p) on the implementation of personnel management practices on the example of small and medium scale enterprises in Kwara). The study results confirm that the small and medium scale enterprises in Kwara actively use personnel management under the influence of environmental factors. The study empirically confirms and theoretically proves the feasibility to consider such variables as the funding availability, the size of the firm, and the type of ownership in the business management process.

Keywords: Human Resources, Human Capital Theory, Management, Nigeria, Small and Medium Scale Enterprises.
Rootstock and Plastic Mulch Effect on Watermelon Flowering and Fruit Maturity in a Verticillium dahliae–Infested Field
Authors: Devi Pinki , Perkins-Veazie Penelope , Miles Carol A.
Published: July 2020

Separately, grafting and the use of plastic mulch can increase yield, quality, and early harvest of watermelon (Citrullus lanatus), especially when plants are under biotic and/or abiotic stress. A 2-year field study was conducted to evaluate the combination of four different rootstocks and two types of plastic mulch (black and clear) on date of watermelon first flowering, fruit ripening, yield, and fruit quality when plants were exposed to Verticillium dahliae. Seedless watermelon cv. Secretariat was grafted onto rootstocks Lagenaria siceraria cv. Pelop, Benincasa hispida cv. Round, and two interspecific hybrid squash rootstocks Cucurbita maxima × C. moschata cvs. Super Shintosa and Tetsukabuto, with nongrafted ‘Secretariat’ as the control. Fruit were harvested 0, 7, and 14 days after both the leaflet and tendril attached to the fruit pedicel were completely dry (fruit considered to be physiologically mature). The area under the disease progress curve (AUDPC) values for verticillium wilt were not different for mulch type in either year, although the overall AUDPC value was greatly reduced in the four grafted treatments (227) compared with nongrafted (743). There was no difference in days to male or female flowering due to mulch type or year, and rootstock did not affect first flowering of male flowers. Female flowering was 14 and 11 days later in 2018 and 2019, respectively, for ‘Secretariat’ grafted onto bottle gourd ‘Round’ compared with ‘Secretariat’ grafted onto ‘Tetsukabuto’. Female flowering of ‘Secretariat’ on ‘Round’ was also 7 days later compared with nongrafted ‘Secretariat’ both years. However, days to first harvest was not different with mulch or rootstock and was 92 days after transplanting (DAT) in 2018 and 114 DAT in 2019. There was no difference in yield (fruit number and weight) due to year, harvest date, or mulch, but there was a difference due to grafting. ‘Secretariat’ grafted onto ‘Super Shintosa’ had the greatest total number and weight of fruit per plant (3.7 and 14.8 kg, respectively), and nongrafted ‘Secretariat’ had the lowest (0.7 and 3.2 kg, respectively). Fruit quality attributes hollow heart formation (rating 3.2/5 on average), hard seed count (6 on average), total soluble solids (11% on average), and lycopene content were not different among mulch type, rootstock treatment, or harvest date; however, lycopene content did differ due to year (52.44 and 32.51 µg·g−1 in 2018 and 2019, respectively). Flesh firmness was highest for watermelon grafted onto ‘Super Shintosa’ rootstock (6.7 N) and lowest for nongrafted watermelon (4.3 N). Overall, rootstocks reduced verticillium wilt severity and increased fruit yield whereas mulch had no effects, and 5 V. dahliae colony forming units (cfu)/g of soil may be the minimum level for impact on watermelon fruit yield.
Dwarfing Effects of Chlormequat Chloride and Uniconazole on Potted Baby Primrose
Authors: Zhang Mengzi , Yang Jie , Pan Huitang , Pearson Brian J.
Published: July 2020

Baby primrose (Primula forbesii) is a newly cultivated and valuable ornamental plant with great market potential for both indoor and landscape use. As a container plant, baby primrose has long, weak flower stalks that can easily lodge, resulting in poor-quality plants, especially during transportation. To control plant height and subsequently prevent flower peduncle lodging, we investigated the effects of two plant growth regulators (PGRs), chlormequat chloride (CCC) at 0, 250, 500, or 750 ppm and uniconazole (UNI) at 25, 50, or 75 ppm on growth, development, and flowering of two cultivars of baby primrose, Fragrant Luolan and Red Star. Plant growth regulators at the proposed concentrations were applied twice throughout the experiment. Both PGRs significantly suppressed plant height in both cultivars, with a 16% to 27% reduction by CCC and 50% to 59% by UNI compared with untreated plants. Among CCC-treated groups, plants were shortest when CCC was applied at 500 ppm; plant height was suppressed more when treated with UNI. In both cultivars, UNI significantly suppressed the first, second, and third peduncle lengths. Furthermore, CCC affected peduncle length, but to a lesser extent than UNI. Plant growth regulator applications generally had little effect on flower characteristics of baby primrose. Neither PGRs influenced the inflorescence number and flower size; however, PGRs did increase the number of floral whorls and suppressed pedicel length of ‘Red Star’. New leaf growth was suppressed by both PGRs. In addition, peduncle cell length and width were both significantly suppressed by PGR applications. We concluded that two foliar applications of UNI at 25 ppm comprised the most effective method of controlling baby primrose plant height while maintaining desirable flower traits at a relatively low production cost. Results of this study provide guidance for techniques that can be used to effectively control the plant height of potted baby primrose for commercial greenhouse production.
MODERN ASPECTS OF THE PROBLEM OF FRACTURES OF THE PROXIMAL FEMULAR
Authors: Hurbanova Tamara
Published: August 2020

The purpose of the study is to study the current global clinical and epidemiological features of proximal hip fractures and the risks of their development and spread. The paper identifies the main aspects of the spread and treatment of fractures of the proximal femur; main world modern epidemiological characteristics of hip fractures and levels of risks of their development and spread. The relationship between comorbidities in patients with proximal hip fractures and the risk of various treatment complications is shown. The main types of treatment tactics are identified, the groups of the most common comorbidities in such patients are given. As a result of the work it was established: the percentage of fractures of the proximal thigh is 9.00–45.00 % among all skeletal fractures in the older age group and among all age categories – 17.00–24.00 %; global annual morbidity is 1.7 million people, and mortality – 11.00–23.00 % in 6 months and 22.00–29.00 % in a year; increase in the frequency of these fractures with age with doubling after 50 years every ten years; average age of patients – 75–79 years; predominance of women over men in 2-3 times; the lowest annual age-standardized cases among women are in Nigeria, South Africa, Tunisia and Ecuador, and the highest are in Denmark, Norway, Sweden and Austria, which is also typical for men; significant economic burden of treatment and high levels of fractures with osteoporosis, cardiovascular disease, diabetes, chronic obstructive pulmonary disease and more; the advantage of surgical treatment over conservative.
CHANGES IN THE MORPHOLOGIC STATE OF RED BLOOD CELLS IN PATIENTS WITH POLYTRAUMA
Authors: Matvieienko Mariia , Gryshchenko Alena , Baranova Nadiia , Sukesh Arora , Bausov Ievgen
Published: August 2020

The measurement of RBC indices is of particular importance as an indirect intermediate component of the recovery process after exposure to hypoxia, ischemia, hypothermia in patients with traumatic disease due to polytrauma.

The aim of this study was to evaluate the parameters of the morphologic state of red blood cells as a reaction of patients with traumatic disease.

Materials and methods.A prospective study was carried out evaluation of 120 patients suffering from polytrauma. The patients were divided into 3 groups according to the principle of using additional substances as a part of IC. The parameters of morphologic state of red blood cells were studied.

Results and discussion. The course of acute and early periods of traumatic disease has accompanied variability morphological forms of red blood cells, as evidenced by a decrease in MCV and RDW increased levels of the 3rd to 5th day. The optimized therapy used in the treatment of patients, has a positive effect on the parameters of red blood cells, contributes to a better recovery of red blood cells after hypoxia resulting multiple trauma.

Conclusion. The study has demonstrated variations in the morphologic properties of red blood cells in the acute and early period of traumatic disease, as confirmed by pathological changes of the erythrocyte indices. The administration of the proposed therapy with the use of D-fructose-1.6-diphosphate sodium salt of hydrate has a positive effect on the parameters of red blood cells, contributes to a better recovery after hypoxia resulting multiple trauma. Given this, the calculations of the red blood cell indices may carry additional diagnostic information, which allows identify trends for not obvious pathological changes and quality of treatment.
Prenatal diagnosis of obstructive pulmonary disease: atresia of the main
bronchus
Authors: A.R. Sleptsov
Published: August 2020

A case of prenatal diagnosis of atresia of the main bronchus of the right lung at 21 weeks of gestation is
presented. Right lung was increase and high echogenic. An anechogenic structure (bronchocele) was visualized
in the region of the lung root. The left lung is sharply hypoplastic, the heart is shifted to the left, ascites in the
abdominal cavity. Pregnancy was interrupted for medical reasons. The interest of the publication is due to the
rarity of the malformation.
Real possibilities of early prenatal diagnosis of coronary-right ventricular
fistula
Authors: O.L. Galkina
Published: August 2020

Experience of prenatal ultrasound diagnosis of coronary-right ventricular fistula at first trimester of gestation
is presented
The experience of legal regulation of the pre-implantation genetic
diagnosis procedure in Israel and the prospects for its borrowing in
Russian conditions
Authors: N.A. Altinnik , V.V. Komarova , M.A. Borodina et all
Published: August 2020

Objectives. The purpose of this study was to study the legal regime of pre-implantation genetic diagnosis
(PGD) procedures in Israel in the context of the formation of the concept of legal regulation of this diagnosis
in the Russian Federation.
Materials. The legal acts and doctrinal sources of Israel on the problems of PGD and genetic research are
examined. Methods used: general philosophical, general scientific, private scientific, special (structural-legal,
comparative-legal, formal-legal).
Results. The features of the legal regulation of the PGD procedure in Israel are determined, the ways of
partial borrowing of such in Russia are proposed.
Conclusions. It has been established that the general concept of legal regulation of PGD in Israel can be
proposed for borrowing due to the following components: 1) an integrated approach to legal regulation of PGD
in which the recommendations for diagnostics are formulated based on the results of the implementation of state
programs to support genetic studies and the fight against congenital diseases; 2) a combination of legislative
regulation of basic guarantees in the field of PGD with subjective by-law regulation of indications and
conditions for each stage of diagnosis; 3) a combination of legislative and by-laws regulation with regulation
at the level of professional guidelines; 4) the flexibility of normative legal regulation, which allows authorizing
the implementation of PGD in certain non-standard cases; 5) the existence of special requirements for the content
of genetic counseling in PGD, which serves as an important guarantee of protecting the rights of consumers
of medical services.
Enhanced adsorption of methylene blue from textile wastewater by using natural and artificial zeolite
Authors: Turp Sinan Mehmet , Turp Güldane Aslı , Ekinci Necla , Özdemir Saim
Published: August 2020

This study investigated the adsorption of methylene blue with natural and artificial zeolite. The effect of pH, contact time, initial concentration and adsorbent dose on adsorption was also investigated. An artificial dye was prepared. Adsorption removal efficiency was low at pH = 2, 3 and 4 but it was quite high at pH = 7. It was determined that the contact time reaches equilibrium within 60 minutes in the adsorption of methylene blue with natural and artificial zeolite. The initial dyestuff concentration for both adsorbents was 5 mg/L. For the removal of methylene blue, a 0.5 g natural and artificial zeolite dosage was sufficient. In order to express the adsorption of natural and artificial zeolite on methylene blue, Langmuir, Freundlich, Temkin and Dubinin-Radushkevich (D-R) isotherm models were examined. In the isotherm study, both natural and artificial zeolite adapted to the Langmuir isotherm model. Langmuir correlation coefficient was 0.998 for artificial zeolite and 0.993 for natural zeolite. Both adsorbent materials best fit into the pseudo-second kinetic model with similar correlation coefficient values of 0.999.
Utilization of rural domestic sewage Tailwaters by Ipomoea aquatica in different hydroponic vegetable and constructed wetland systems
Authors: Gong Liying , Chen Guiding , Li Jialin , Zhu Guangcan
Published: August 2020

For the utilization of nitrogen and phosphorus in rural sewage tailwaters after biological treatment, four systems were examined regarding their ability to purify tailwaters of rural domestic sewage: a hydroponic vegetable system (HV), a subsurface flow constructed wetland (SFCW), a compound system with HV followed by SFCW (HV-SFCW), and a compound system with SFCW followed by HV (SFCW-HV). Parameters of the four systems were optimized to maximize the utilization efficiency of nitrogen and phosphorus, and the characteristics and pollutant removal efficiency of the process were investigated. Moreover, the edible security of vegetables was also evaluated. Results showed that the optimal hydraulic loadings for the four systems were 0.2, 0.3, 0.3, and 0.3 m3/(m2·d) (the lowest being the HV), respectively. In the combined system of HV-SFCW, high contribution proportions of the HV unit to the removal of COD, TN, and TP were obtained, reaching 46.7%, 58.1%, and 53.7%. The heavy metal content of plants harvested met the standards of the National Food Safety Standard Limit of Pollutants in Food (GB 2762-2012). Overall, the compound HV-SFCW system achieved the best performance, ensuring that effluent water quality met national standards and realized the effective utilization of nitrogen and phosphorus.
Desenhando um ensaio visual:
Authors: Dote Alice
Published: August 2020

Este ensaio visual traz imagens produzidas ao longo de uma pesquisa em Antropologia Urbana no Centro de Fortaleza/CE. Através de caminhadas etnográficas, percorremos, percebemos e habitamos o espaço. O movimento dos passos provoca-nos outros deslocamentos, como os metodológicos. O desenho surge, imprevistamente, como mais uma maneira de nos implicarmos na e junto à cidade. Assumido como método, compreende uma reflexividade no seu gesto, uma maneira de pensar não só o espaço, mas a própria pesquisa e o fazer antropológico. Com as imagens partilhadas, buscamos lançar inquietações sobre o que o desenho, mais do que uma representação de algo, pode nos dar a ver nos encontros que ele gera e nos rastros que ele deixa.
A EDUCAÇÃO POPULAR EM SAÚDE COM GRUPOS DE IDOSOS DIABÉTICOS NA ESTRATÉGIA SAÚDE DA FAMÍLIA: UMA PESQUISA-AÇÃO
Authors: Almeida Marise Soares , Melo Ricardo Henrique Vieira , Vilar Rosana Lúcia Alves de , Silva Alexandre Bezerra , Melo Mércia Lima de , Júnior Antônio Medeiros
Published: August 2020

Introdução: a Educação Popular em Saúde (EPS) remete indivíduos e grupos à troca de saberes e experiências, permitindo-lhes associar a saúde ao resultado das suas condições de vida levando a uma emancipação do sujeito. Objetivos: conhecer e promover ações educativas com portadores de Diabetes Mellitus (DM); realizar oficinas de capacitação em EPS com trabalhadores de saúde; conhecer e desenvolver ações educativas participativas com grupos de diabéticos; e avaliar os resultados das ações realizadas para os trabalhadores e usuários, em uma Unidade de Saúde da Família em Natal/RN. Métodos: Trata-se de uma pesquisa-ação com o referencial teórico da Teoria da Educação Libertadora, centrada na pedagogia problematizadora. Participaram da pesquisa trinta trabalhadores de saúde e trinta e seis usuários diabéticos. As ações foram organizadas através de rodas de conversa, dinâmicas de grupo, narrativas de vida, relatos de experiências, e explicitação de saberes, desejos, limitações, crenças e valores socialmente construídos. A coleta dos dados foi realizada através da Técnica de Associação Livre de Palavras, entrevista semiestruturada e grupo focal. O material empírico foi submetido a análise de ocorrência (Bardin) com auxílio do programa IRAMUTEQ (Ratinaud; Marchand). Resultados e discussão: Foram geradas palavras, expressões e categorias, a partir dos temas abordados e de situações criativas mostrando que a EPS vem sendo incorporada timidamente no processo educativo dos sujeitos deste estudo e bem distante dos princípios de participação, organização de um trabalho político, ampliação dos espaços de diálogo, respeito, de solidariedade e tolerância entre os diversos atores envolvidos no enfrentamento dos problemas de saúde, fundamentais para o aperfeiçoamento na construção de práticas saudáveis da atenção básica. Considerações finais: A utilização de práticas ativas de ensino-aprendizagem, centradas na ampliação da escuta e em capacitações sobre EPS, poderá possibilitar mudanças no cenário onde os usuários e trabalhadores de saúde atuam com a diabetes mellitus.
A OPERACIONALIZAÇÃO DO SUS NA PREVENÇÃO E CONDUÇÃO DE CASOS DE SUICÍDIOS: ANÁLISE DOCUMENTAL
Authors: Garbin Clea Adas Saliba , Pupim dos Santos Luis Felipe , Moimaz Suzely Adas Saliba , Saliba Orlando
Published: August 2020

Introdução: O suicídio é tido como um fenômeno complexo, multicausal, fruto da interação de fatores de ordem filosófica, biológica, antropológica, psicológica, e social, considerado nos dias de hoje um grave problema de saúde pública. Objetivo: realizar uma análise documental dos materiais lançados pelo SUS relacionados às medidas a serem adotadas em casos e tentativas de suicídio, bem como nos meios previni-las. Método: trata-se de um estudo descritivo, no qual foram verificadas as portarias e manuscritos do SUS relacionadas ao suicídio, tendo sido consultados oito documentos oficiais. Resultados: a primeira portaria a tratar especificamente do assunto, Portaria nº 1.876, foi lançada em 2006, e instituiu as Diretrizes Nacionais para Prevenção do Suicídio, norteando as estratégias do Ministério da Saúde para atuação e contenção do fenômeno. A partir dela, outros documentos foram instituídos, visando o aprimoramento do acesso, acolhimento, e tratamento aos indivíduos predispostos a desenvolverem depressão, ou que estão em situações de risco, além de garantir maiores esforços e investimentos para grupos específicos. Conclusões: as portarias estabelecidas garantem ao usuário do SUS acolhimento e acompanhamento, desde o nível de atenção básica até a atenção especializada.
LEVANTAMENTO DA GEODIVERSIDADE DO SETOR NORDESTE DO MUNICÍPIO DE PIRIPIRI/PIAUÍ, BRASIL
Authors: Amorim João Cassiano Pinto de , Aquino Cláudia Maria Sabóia de
Published: August 2020

A presente pesquisa objetivou levantar a nível exploratório a geodiversidade e o patrimônio geológico/geomorfológico do município de Piripiri/Piauí como suporte a iniciativas de geoconservação e geoturismo, fomentando assim pesquisas relacionadas a estas temáticas, por demais importantes, porém ainda escassas no Estado. Para essa caracterização da Geodiversidade de Piripiri realizou-se a inventariação – segundo a metodologia de Oliveira (2015) – considerando as etapas de identificação, avaliação e seleção dos geomorfossítios do município em questão, contribuindo assim para os estudos relativos à geodiversidade no estado do Piauí. Os locais de interesse geológico/geomorfológico foram inventariados, isto é, identificados/avaliados qualitativamente, em seguida, caracterizados e quantificados. Foram identificados 9 geomorfossítios na porção Nordeste do município, a saber: Geomorfossítios Cachoeira do Bota Fora, Afloramento de Arenito do Bota Fora, Açude Caldeirão, Blocos de Arenito do São Bento, Sítio da Gruta, Casa de Pedra, Pedra da Tartaruga, Pedra do Atlas e Sítio dos Bruxos. Na sequência os mesmos foram avaliados qualitativamente considerando distintos critérios e ranqueados para fins de analise de suas relevâncias. Os geomorfossítios de maior relevância identificados foram Açude Caldeirão, Sítio dos Bruxos, Cachoeira do Bota Fora, Casa de Pedra, Pedra do Atlas, Pedra da Tartaruga e Sítio da Gruta por outro lado os de menores pontuações foram os Blocos de Arenito do São Bento e o Afloramento de Arenito do Bota Fora. Constatou-se de modo geral a necessidade de implantação de infraestrutura nestes geomorfossítios de modo que os mesmos possam ser abertos ao público, para fins geoturísticos, como forma de gerar renda a população do referido município.

Palavras-chave: Geodiversidade. Patrimônio Geológico/Geomorfológico. Geomorfossítios.
TAX CONTROL OF VAT REFUND IN RUSSIA AND IN THE SCANDINAVIAN COUNTRIES ON THE EXAMPLE OF TIMBER INDUSTRIES
Authors: LABUNETS Yulia E. , MAYBUROV Igor A.
Published: August 2020

This article is devoted to the study of the mechanisms of tax control of value-added tax reimbursement in Russia and in the Scandinavian countries.
The research methodology is based on a comparative analysis of current VAT taxation mechanisms in Russia and in Norway, Sweden, and Finland. In addition, a comparison was made of the basics of organizing the process of tax control over the reimbursement of value added tax in these countries. This paper examines statistical data on the volume of value-added tax receipts to the budget system of the Russian Federation from taxpayers engaged in business activities in the Russian timber industry.
It was found that with the General trend of increasing the level of business activity of economic entities in the timber industry, the share of income from value-added tax for the period 2012-2018 was on average negative, due to the presence of significant volumes of export operations and the predominance of VAT refund processes over its payment to the budget system of the Russian Federation.
The paper examines the economic essence of the concept of compensation for value added tax on the example of branches of the timber industry as the right of VAT taxpayers established by the legislation on taxes and fees. At the same time, we also studied the negative impact on the level of tax security of the country of mechanisms for unjustified compensation of value-added tax on the example of the Russian timber industry.
The mechanism of tax control of the value added tax claimed for reimbursement by taxpayers of the timber industry sectors of the Russian Federation is considered. positive trends in automation of control processes during in-house VAT tax audits are noted.
We have studied the processes of value-added tax reimbursement and the mechanisms of tax control of these processes in the Scandinavian countries.
Based on the results of the study, recommendations are proposed for adapting certain control methods used by tax authorities of foreign countries in the process of tax control of value-added tax compensation to the existing tax control mechanism in Russia.
Falcipain-2 and Falcipain-3 Inhibitors as Promising Antimalarial Agents
Authors: Ettari Roberta , Previti Santo , Di Chio Carla , Zappalà Maria
Published: August 2020

Malaria remains a serious problem in global public health, particularly widespread
in South America and in tropical regions of Africa and Asia. Chemotherapy is actually the
only way to treat this poverty-related disease, since an effective vaccine is not currently
available. However, the onset of resistance to the most common antimalarial drugs sometimes
makes the current therapeutic regimen problematic. Therefore, the identification of new targets
for a new drug discovery process is an urgent priority. In this context, falcipain-2 and falcipain-
3 of P. falciparum represent the key enzymes in the life-cycle of the parasite. Both falcipain-
2 and falcipain-3 are involved in hemoglobin hydrolysis, an essential pathway to provide
free amino acids for the parasite metabolic needs. In addition, falcipain-2 is involved in
cleaving ankirin and band 4.1 protein, which are cytoskeletal elements essential for the stability
of the red cell membrane. This review article is focused on the most recent and effective
inhibitors of falcipain-2 and falcipain-3, with particular attention to peptide, peptidomimetic
or nonpeptide inhibitors, which targeted one or both the malarial cysteine proteases, endowed
with a consistent activity against P. falciparum.
A Case of Acute Generalized Exanthematous Pustulosis by Cefixime with Oral Mucosal Involvement
Authors: Namoju Ramanachary , Ismail Mohammed , Golla Vinay Kumar , Bamini Tejaswini , Akarapu Thanmaya Lakshmi , Baloju Deepika
Published: July 2020

Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse
reaction characterized by the development of numerous sterile and non-follicular pustules on an erythematous
base with no or minimal mucous membrane involvement associated with fever and leucocytosis.
Cefixime is a cephalosporin-type beta-lactam antibiotic commonly used for the management
of several infections. The Cefixime-induced AGEP cases are known to be rare. Here, we present
the case report of a 26-year old female who developed Cefixime-induced AGEP with mucosal
membrane involvement. To the best of our knowledge, this is the first case to report the mucosal
membrane involvement in Cefixime-induced AGEP. We are presenting this case report to draw the
attention on the existence and plethora of symptoms of Cefixime-induced AGEP hoping that the
clinicians will reckon these in their differential diagnosis and implement the appropriate management
strategies for this rare adverse event in their clinical practice.
The Klf6 Super-enhancer Determines Klf6 Sensitivity to BRD4 Inhibitors in Human Hepatoma (HepG2) Cells
Authors: Ri KumChol , Ri MyongRyong , Song YongJae , Kim KyuHwan , Kim Chol
Published: August 2020

Background:

The Klf6 gene, belonging to Krüppel-like family of C2H2 zinc finger transcription
factors, is strongly associated with tumor formation through high somatic mutations in
carcinomas of the prostate, liver, colon, stomach, lung, neck, pituitary gland and nervous system.
Recently, Klf6 super-enhancer which strongly regulates Klf6 gene expression has been identified,
and the function of Klf6 super-enhancer which regulates cell growth was studied.

Objective:

The development of inhibitors targeting BRD4-binding super-enhancers is a potential
target therapeutic strategy for tumor therapy. However, the suppression of Klf6 super-enhancer
function by BRD4 inhibitors is not known.

Methods:

CRISPR-Cas9 editing technique was used for the Klf6 super-enhancer deletion experiment,
and the expression levels of several genes for cell clones were detected by qRT-PCR analysis
and Western blotting. Cell proliferation assay was applied to evaluate the functional role of
Klf6 super-enhancer using several BRD4 inhibitors. The interaction of several BRD4 inhibitors
against the target protein was analyzed by molecular docking simulation.

Results:

JQ-1, a human BRD4 inhibitor, inhibited Klf6 gene expression and its activity in HepG2
cells in a time and dose-dependent manner while simultaneously inhibiting cell growth. Besides,
BETd-246, a human BRD4 inhibitor, strongly inhibited Klf6 gene expression, significantly inhibited
cell growth, and exhibited higher efficacy than JQ-1. Molecular docking studies revealed that
some key residues were critical for ligand-receptor interactions by forming hydrogen bonds with ligands
(JQ-1: ASN140, BETd-246: ASN140, TYR106, LYS65, GLN58, MET105, and MET53).

Conclusions:

Our findings suggest that KLF6 is regulated by Klf6 super-enhancer and the targeting
of Klf6 super-enhancer by BRD4 inhibitors may be an effective therapeutic strategy for liver cancer
therapy.
The Role of an Ultrasound-Guided Block of the Deep Plane of the Serratus Muscle in a Modified ERAS Protocol for Cardiac Surgery
Authors: Coppolino Francesco , Sansone Pasquale , Passavanti Maria B. , Pace Maria C. , Sepolvere Giuseppe , Aurilio Caterina
Published: July 2020

To date, the use of multimodal techniques can allow substantial opioid-sparing and can reduce pain by using the local and systemic effects of different types of analgesics. Aims: This case report describes a modified ERAS protocol specific for cardiac surgery with the ultrasound-guided block of the deep plane of the serratus muscle (SAP deep block) in a multimodal opioid-sparing approach. \ Two male patients, aged 62 and 67, undergoing elective mini-invasive off-pump Cardiopulmonary Bypass Grafting (CPB), were treated with an opioid-sparing multimodal anesthesiological approach based on the continuous ultrasound-guided SAP deep block. The continuous ultrasound-guided SAP deep block alone can be used in the case of mini-left thoracotomy off-pump cardiopulmonary bypass grafting implementing a multi-modal opioid-sparing strategy. It seems effective in obtaining good (2 hours) weaning from mechanical ventilation, quick (36 hours) discharge from post-operative intensive care, and good post-operative pain control (NRS < 5) even in elderly and frail patients.
Predicting Election Results from Twitter Using Machine Learning Algorithms
Authors: Sucharitha Yadala , Vijayalata Yellasiri , Prasad Valurouthu K.
Published: July 2020

Introduction:

In the present scenario, the social media network plays a significant role in
sharing information between individuals. This incorporates information about news and events that are
presently occurring in the worldwide. Anticipating election results is presently turning into a fascinating
research topic through social media. In this article, we proposed a strategy to anticipate election results
by consolidating sub-event discovery and sentimental analysis in micro-blogs to break down as well as
imagine political inclinations uncovered by those social media users.

Methods:

This approach discovers and investigates sentimental data from micro-blogs to anticipate the
popularity of contestants. In general, many organizations and media houses conduct a pre-poll review and
obtain expert’s perspectives to anticipate the result of the election, but for our model, we use Twitter data to
predict the result of an election by gathering information from Twitter and evaluate it to anticipate the result
of the election by analyzing the sentiment of twitter information about the contestants.

Results:

The number of seats won by the first, second, and third party in AP Assembly Election
2019 has been determined by utilizing Positive Sentiment Scores (PSS’s) of the parties. The actual
results of the election and our predicted values of the proposed model are compared, and the outcomes
are very close to actual results. We utilized machine learning-based sentimental analysis to
discover user emotions in tweets, anticipate sentiment score, and then convert this sentiment score to
parties' seat score. Comprehensive experiments are conducted to check out the performance of our
model based on a Twitter dataset.

Conclusions:

Our outcomes state that the proposed model can precisely forecast the election results with
accuracy (94.2 %) over the given baselines. The experimental outcomes are very closer to actual election
results and contrasted with conventional strategies utilized by various survey agencies for exit polls and
approval of results demonstrated that social media data can foresee with better exactness.

Discussion:

In the future, we might want to expand this work into different areas and nations of the
reality where Twitter is picking up prevalence as a political battling tool, and where politicians and
individuals are turning towards micro-blogs for political communication and data. We would likewise
expand this research into various fields other than general elections and from politicians to
state organizations.
Baby’s First Cry:A Prognostic Study by Varmam Therapy
Authors: Priyananth Deiva , Shonmugam Dr.N.
Published: August 2020

This paper presents the efficacy and importance of Varmam application and treatment applied on new born to prevent Birth Asphyxia. In this study Varmam technique was tried to prevent birth asphyxia by bringing about the first cry in a baby. This is one of the main causes for Infant mortality. It is much more in developing countries. In India out of 25 million infants born every year, 3 - 5% experience birth asphyxia, which amounts to almost 7,50,000 infants. Infant mortality rate is 57 out of every 1000 live births in India, which is comparatively higher than developed countries. One of the main causes is birth asphyxia.
Reseña. Bandieri, S., Coria-López, L., Dabús, C., Llach, L., Meloni, O., Rosales-Rosales, J. y Visintini, A. (2020). Historia económica de las regiones argentinas, 1810-2010. Buenos Aires: Biblos.
Authors: Perren Joaquín
Published: August 2020

En las dos últimas décadas, la historia económica argentina ha experimentado un auténtico boom. Dejó de ser la hermana menor de la nueva historia política y la historia social, buques insignia de la renovación historiográfica de la inmediata postdictadura, para convertirse en un campo académico de auténtica envergadura. La multiplicación de revistas especializadas, la relevancia que adquirieron las Jornadas Argentinas de Historia Económica en el calendario científico nacional y el creciente número de tesis sobre la materia son algunos de los síntomas de una especialidad que fue tomando distancia de sus humildes orígenes. Una multitud de trabajos abrió fronteras que resultaban inimaginables tan solo algunas décadas atrás, desde una caracterización más ajustada de los actores que dieron vida a la campaña hasta los siempre complejos tempos de la industrialización. Este rico corpus fue la base sobre la cual se sostuvieron los primeros esfuerzos de síntesis. El libro reseñado debe inscribirse en esa tradición, bastante reciente, por cierto, inaugurada por obras del calibre de autores como Rapoport (2003), Gelman (2006), Míguez (2008), Hora (2010) y Belini y Korol (2012).
Contabilidad cultural: un campo emergente enfocado en salvaguardar el patrimonio cultural
Authors: Cano Mejía Vanessa , Arias Suárez Juan David , Asuaga Taran Carolina
Published: August 2020

Este artículo busca aportar al desarrollo de la contabilidad cultural como un campo emergente transdisciplinar dentro de la disciplina contable. Para ello se recurre a una metodología cualitativa de análisis dialéctico y de revisión sistemática de la literatura especializada. Así, se analizan los vínculos y tensiones conceptuales entre la contabilidad, la cultura y el patrimonio cultural, y se exploran los principales avances en este campo, así como sus perspectivas metodológicas de medición, valoración y control contable para los bienes culturales. Se muestra la importancia, como también los retos y encrucijadas, que conlleva este campo emergente, su perspectiva epistemológica, las tensiones normativas y su función social. Así, se ofrece un espectro amplio de comprensión del problema y alternativas heterodoxas a la medición tradicional, más fieles a la complejidad del campo cultural.