bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Biochar on Soil Properties
Authors: Iqbal Shazia , Aziz Humaira , Naseem Munaza , Irfan Muhammad
Published: September 2024

Soil is the most significant source and home of many nutrients and
microflora. There is an urgent need to maintain sustainable agricultural production
methods due to the rapid deterioration of agricultural areas and soil quality because of
population growth and excessive use of chemical fertilizers. Biochar is a solid,
carbonaceous material produced under a limited oxygen environment. Nowadays, it is
considered a potential amendment in comparison to inorganic fertilizers as they affect
soil health. It not only improves plant growth but also maintains soil health by
optimizing soil's physical (e.g., bulk density, surface area, hydraulic properties, and
water availability) and chemical properties (e.g., pH, electrical conductivity, cation
exchange capacity, and organic matter). Keeping in view the effects of biochar on soil
quality indicators, in this chapter, we will discuss the potential of biochar in restoring
soil physical and chemical health.
Impact of Biochar on Plant Pathogen Control
Authors: Akhter Adnan , Abbas Muhammad Taqqi , Anwar Waheed , Khan Tiyyabah , Ali Khan Hafiz Azhar
Published: September 2024

It has been reported that organic amendments can lessen the impact of
pathogen-caused plant diseases. Researchers have been looking for alternative
materials for growth mixes for plants, especially for pots, as a result of the growing
demand for substrates without soil and the escalating environmental concerns
associated with the utilization of resources that are not renewable, such as peat. A
variety of biochar effects help to prevent root or foliar fungal infections by altering root
exudates, soil characteristics, and nutrient availability, all of which influence the
proliferation of antagonistic microorganisms. Biochar's induction of systemic plant
defenses in the roots to combat foliar pathogenic fungus and the activation of stress
hormone responses are all indicators of coordinated hormonal transmission within the
plant. Additionally, nematodes and pest insects are controlled by biochar. The primary
mechanisms of action of plant-parasitic nematodes are changes in the diversity of soil
microbes, the release of nematicidal chemicals, and the development of plant defenses.
In this chapter, we looked at how the health and disease of plants are affected by
biochar as a component of the growing medium. Biochar treatments show a lot of
promise, according to this study, but not enough research has been done to support
their widespread use as a soil supplement in modern agricultural systems. More
research on the processes that drive biochar disease suppression and long-term field
tests are required to make biochar a safe, effective, and cost-effective tool for
controlling plant diseases.
Bioactive Compounds in Cancer Therapy and Chemoprevention
Authors: Keerthana Chenicheri Kizhakkeveettil , Rayginia Tennyson Prakash , Aiswarya Sreekumar Usha Devi , Shifana Sadiq Chembothumparambil , Anto Ruby John
Published: September 2024

The continuous increase in the number of cancer cases and rates of
cancer-related mortality globally is a highly concerning issue. Drug-induced toxicity,
drastic side effects and chemoresistance associated with conventional
chemotherapeutics warrant the need for novel, efficient, and safer alternative
therapeutic approaches to help combat cancer. Plants are a rich source of bioactive
compounds with potential anti-cancer activity. Extensive research on the
chemotherapeutic efficacy of various plant-derived bioactive compounds is being
carried out across the world. While cancer chemoprevention approaches prevent, delay,
or suppress tumor incidence, chemosensitization approaches employ synthetic or
natural bioactive agents to enhance the efficacy of conventional chemotherapeutic
drugs at lower doses. Numerous studies have documented the efficiency of both of
these approaches in managing different types of cancer. The scope of this chapter
encompasses a comprehensive analysis of the current status and limitations of
conventional chemotherapeutics and the clinical relevance of chemoprevention and
chemosensitization strategies for the effective management of cancer, with a special
emphasis on the potency of some of the major phytochemicals that are extensively
being studied as novel chemopreventives and/or chemosensitizers, globally. Besides,
an overview of the underlying mechanisms of action of these phytochemicals in
regulating the signal transduction events associated with cancer progression, has also
been discussed in this chapter.
Medicinal Plants and Cancer Therapy and Chemoprevention
Authors: Kalaiarasi Giriraj , Kamatchi Thangavel Sathiya , Parveen S.
Published: September 2024

Cancer is still the second-leading cause of death in industrialized countries.
The development of resistance to anticancer drugs and the severe side effects of current
drugs prevent treatment with drug doses high enough for long-lasting remissions or
sustainable cures. There have been unprecedented efforts to uncover new treatments
and the knowledge of cancer has been tremendously increasing for the past few
decades. Medicinal plants are a fertile ground to be used as phytotherapy and to isolate
phytochemicals with interesting pharmacological features. Medicinal plants are being
increasingly documented as useful consistent treatments for cancer. A large volume of
clinical studies have reported the beneficial effects of herbal medicines on the survival,
immune modulation, and quality of life (QOL) of cancer patients when these herbal
medicines are used in combination with conventional therapeutics. This book chapter
should provide useful technological support for the evidence-based application of
herbal medicines in cancer therapy. Natural products have always been a major source
of drug development in cancer therapy.
TENSÃO ENTRE O DIREITO INFORMACIONAL E A CONDUÇÃO DE PESQUISAS EMPÍRICAS
Authors: Pozzatti Ademar , Campara Verdum Ana Carolina
Published: September 2024

O desenvolvimento de pesquisas empíricas sobre o Sistema Interamericano de Direitos Humanos (SIDH), incluindo a Comissão (CIDH) e a Corte Interamericana de Direitos Humanos (Corte IDH), depende da disponibilidade de dados oficiais dessas instituições, o que nem sempre acontece. A presente pesquisa contribui com os campos de pesquisa do Direito Internacional e das Relações Internacionais ao oferecer elementos para analisar os limites e as possibilidades para o desenvolvimento de pesquisas empíricas sobre o SIDH. Metodologicamente, o trabalho concilia: pesquisa bibliográfica; diário de pesquisa empírica, elaborado pelos próprios autores no decorrer de uma pesquisa documental sobre soluções amistosas da CIDH e da Corte IDH; e procedimento bibliométrico, para mapear as pesquisas que enfocam a disponibilidade de dados pelo SIDH e as repercussões disso para a produção de pesquisas empíricas. Com relação aos limites, o diário de pesquisa empírica permite concluir que, sobre as soluções amistosas da CIDH, há (i) insuficiência de dados, (ii) inconsistências e contradições, (iii) carência de relatórios em língua portuguesa e (iv) insuficiência de acessibilidade para pessoas com deficiência, e, com relação à Corte IDH, há falta de atualização dos dados e ausência de indexação de todas as suas decisões em seus buscadores oficiais de jurisprudência. Ainda, a literatura identificada pela pesquisa bibliométrica ressalta limites na publicação de dados sobre petições, casos e procedimentos da CIDH e Corte IDH.
PROTEÇÃO DOS DIREITOS DA PERSONALIDADE E DA LIBERDADE NA ERA DA TECNOLOGIA
Authors: Pereira Siqueira Dirceu , Caroline Lima de Souza Bruna
Published: September 2024

A sociedade contemporânea vivencia o que alguns teóricos identificam como período “pós-moderno”, que quebrou diversos paradigmas e estabilidades existentes na modernidade, com grandes alterações nos indivíduos, nas sociedades, nas relações humanas, decorrentes, entre outros fatores, da ascensão da tecnologia e do consumismo como meio de satisfação e identidade pessoal. Tal contexto alterou, ainda, os modos em que o controle e o poder são exercidos nesse período. Desta forma, o artigo visa responder a problemática: a tutela dos direitos da personalidade tem sido eficaz na proteção da liberdade frente ao ser humano pós-moderno e aos novos mecanismos de (psico)poder? Assim, objetiva-se, de forma geral, analisar acerca da (in)suficiência e (in)efetividade da proteção atribuída aos direitos da personalidade na contemporaneidade, frente as características do ser-humano pós-moderno e dos novos mecanismos de (psico)poder da era da tecnologia, em especial no que tange a liberdade dos indivíduos. De forma específica, objetivar-se-á analisar: qual é o panorama do ser humano na pós-modernidade e quais os mecanismos de controle e poder que se encontram vigentes atualmente; e, qual é o cenário contemporâneo da tutela dos direitos da personalidade e acerca da (in)suficiência dessa proteção no que tange a liberdade. Para viabilizar a análise proposta, utilizar-se-á do método hipotético-dedutivo, bem como a metodologia pautada na técnica de revisão bibliográfica não sistematizada. As conclusões foram no sentido de ineficácia dos direitos da personalidade na proteção da liberdade frente ao seu humano pós-moderno e aos novos mecanismos de poder.
TRASLADANDO SUJETOS POLÍTICOS EN CATEGORÍAS JURÍDICAS
Authors: Micaela Alterio Ana
Published: September 2024

Este trabajo examina la construcción de las categorías jurídicas de género, a partir de la sentencia de la Corte Interamericana de Derechos Humanos en el caso Vicky Hernández y otros vs. Honduras, enfocándose en los debates feministas.
Efectos del fuego sobre características físico-químicas y nutricionales del suelo en tierras de vocación forestal
Authors: Ramos-Rodríguez Marcos Pedro , Tigua-Parrales Marlon Javier , Baque-Ramos Jerry Bryan , Manrique-Toala Tayron Omar , Castro-Landín Alfredo Lesvel
Published: September 2024

El fuego, en dependencia de su comportamiento, puede afectar las características de los suelos. El objetivo de este trabajo fue evaluar los efectos del fuego sobre características físico-químicas y nutricionales del suelo en tierras de vocación forestal en Jipijapa, Manabí, Ecuador. Se delimitaron parcelas en combustibles apilados en hileras y dispersos. En los análisis se consideraron variables meteorológicas, del material combustible, del comportamiento del fuego y características físico-químicas y nutricionales del suelo antes y después de la quema. Los valores medios de las variables del material combustible y de los parámetros del comportamiento del fuego fueron numéricamente mayores en las parcelas ubicadas en combustibles apilados. En ambos tipos de parcelas tres meses después de la quema los valores que muestran los factores analizados, si bien son inferiores a los que existían antes de aplicar el fuego, alcanzaron niveles numéricamente similares a los mismos, siendo los porcentajes de arcilla ligeramente superiores.
Customers Adoption and Satisfaction of E-Wallet and UPI Payment System: Evidence from India and Bangladesh
Authors: Gupta Neha , Mukherjee Jeet , Das Arindam , Roy Shuvashish
Published: September 2024

This article explores the impact of selected factors in adopting online payment platforms (AOPP) in India and Bangladesh by applying the extended Technology Acceptance Model (TAM). The factors considered are perceived trust (PT), perceived ease of use (PEU) and perceived usefulness (PU). The impacts of these factors are studied on the adoption and satisfaction of E-Wallet and UPI Payment System in India and Bangladesh. Data was collected from a sample of 199 individuals from India and Bangladesh who uses E-Wallet systems for online financial transactions. The authors have utilised the structural equation modelling (SEM) technique for testing the hypothesised relationships. It was found that three factors: PT, PEU and PU, have a significant impact on the AOPP, and the AOPP, in turn, has a positive impact on customer satisfaction (CS). It is a study of its own kind which identifies the factors impacting the AOPP using the extended TAM model and to establish a relationship between the AOPP and CS in the context of India and Bangladesh. This type of exploratory study can be helpful to the service providers for the development of strategies for the betterment of E-Wallet and UPI services.
Assessing the Impact of Mission Shakti on Women Entrepreneurship through Financial Inclusion: A Study in the Context of Odisha
Authors: Garu Satyaranjan , Dash Srinibash
Published: September 2024

The study seeks to assess the relationship between financial inclusion and women entrepreneurship in the context of Mission Shakti in Odisha. It aims to evaluate the impact of Mission Shakti on women entrepreneurship. The study employs empirical techniques and utilises statistical tools, such as Structural Equation Model, to analyse the collected data. Statistical software like AMOS, SPSS and Excel is being utilised. The primary data is gathered from 499 respondents. The study explores three key constructs: Financial Inclusion, Women Entrepreneurship and Mission Shakti, using Exploratory Factor Analysis. The results of the measurement model indicate that all constructs meet the criteria for validity and reliability. Furthermore, the study finds a significant positive impact of Mission Shakti on women entrepreneurship. This research contributes to the existing knowledge in the field of financial inclusion, Mission Shakti and women entrepreneurship through multivariate analysis. The study emphasises the practical implications of employing modern statistical techniques and primary data for future research in the areas of financial inclusion, Mission Shakti and women entrepreneurship.
Design and Implementation of a Dashboard for Drug Interactions Mediated by Cytochromes Using a Health Care Data Warehouse in a University Hospital Center: Development Study
Authors: Gosselin Laura , Maes Alexandre , Eyer Kevin , Dahamna Badisse , Disson Flavien , Darmoni Stefan , Wils Julien , Grosjean Julien
Published: September 2024

Background

The enzymatic system of cytochrome P450 (CYP450) is a group of enzymes involved in the metabolism of drugs present in the liver. Literature records instances of underdosing of drugs due to the concurrent administration of another drug that strongly induces the same cytochrome for which the first drug is a substrate and overdosing due to strong inhibition. IT solutions have been proposed to raise awareness among prescribers to mitigate these interactions.

Objective

This study aimed to develop a drug interaction dashboard for Cytochrome-mediated drug interactions (DIDC) using a health care data warehouse to display results that are easily readable and interpretable by clinical experts.

Methods

The initial step involved defining requirements with expert pharmacologists. An existing model of interactions involving the (CYP450) was used. A program for the automatic detection of cytochrome-mediated drug interactions (DI) was developed. Finally, the development and visualization of the DIDC were carried out by an IT engineer. An evaluation of the tool was carried out.

Results

The development of the DIDC was successfully completed. It automatically compiled cytochrome-mediated DIs in a comprehensive table and provided a dedicated dashboard for each potential DI. The most frequent interaction involved paracetamol and carbamazepine with CYP450 3A4 (n=50 patients). The prescription of tacrolimus with CYP3A5 genotyping pertained to 675 patients. Two experts qualitatively evaluated the tool, resulting in overall satisfaction scores of 6 and 5 out of 7, respectively.

Conclusions

At our hospital, measurements of molecules that could have altered concentrations due to cytochrome-mediated DIs are not systematic. These DIs can lead to serious clinical consequences. The purpose of this DIDC is to provide an overall view and raise awareness among prescribers about the importance of measuring concentrations of specific drugs and metabolites. Ultimately, the tool could lead to an individualized approach and become a prescription support tool if integrated into prescription assistance software.
Revolutionizing Health Care: The Transformative Impact of Large Language Models in Medicine
Authors: Zhang Kuo , Meng Xiangbin , Yan Xiangyu , Ji Jiaming , Liu Jingqian , Xu Hua , Zhang Heng , Liu Da , Wang Jingjia , Wang Xuliang , Gao Jun , Wang Yuan-geng-shuo , Shao Chunli , Wang Wenyao , Li Jiarong , Zheng Ming-Qi , Yang Yaodong , Tang Yi-Da
Published: September 2024

Large language models (LLMs) are rapidly advancing medical artificial intelligence, offering revolutionary changes in health care. These models excel in natural language processing (NLP), enhancing clinical support, diagnosis, treatment, and medical research. Breakthroughs, like GPT-4 and BERT (Bidirectional Encoder Representations from Transformer), demonstrate LLMs’ evolution through improved computing power and data. However, their high hardware requirements are being addressed through technological advancements. LLMs are unique in processing multimodal data, thereby improving emergency, elder care, and digital medical procedures. Challenges include ensuring their empirical reliability, addressing ethical and societal implications, especially data privacy, and mitigating biases while maintaining privacy and accountability. The paper emphasizes the need for human-centric, bias-free LLMs for personalized medicine and advocates for equitable development and access. LLMs hold promise for transformative impacts in health care.
EyeMatics: An Ophthalmology Use Case Within the German Medical Informatics Initiative
Authors: Varghese Julian , Schuster Alexander , Poschkamp Broder , Yildirim Kemal , Oehm Johannes , Berens Philipp , Müller Sarah , Gervelmeyer Julius , Koch Lisa , Hoffmann Katja , Sedlmayr Martin , Kakkassery Vinodh , Kohlbacher Oliver , Merle David , Bartz-Schmidt Karl Ulrich , Ueffing Marius , Stahl Dana , Leddig Torsten , Bialke Martin , Hampf Christopher , Hoffmann Wolfgang , Berthe Sebastian , Waltemath Dagmar , Walter Peter , Lipprandt Myriam , Röhrig Rainer , Storp Jens Julian , Zimmermann Julian Alexander , Holtrup Lea , Brix Tobias , Stahl Andreas , Eter Nicole
Published: September 2024

The EyeMatics project, embedded as a clinical use case in Germany’s Medical Informatics Initiative, is a large digital health initiative in ophthalmology. The objective is to improve the understanding of the treatment effects of intravitreal injections, the most frequent procedure to treat eye diseases. To achieve this, valuable patient data will be meaningfully integrated and visualized from different IT systems and hospital sites. EyeMatics emphasizes a governance framework that actively involves patient representatives, strictly implements interoperability standards, and employs artificial intelligence methods to extract biomarkers from tabular and clinical data as well as raw retinal scans. In this perspective paper, we delineate the strategies for user-centered implementation and health care–based evaluation in a multisite observational technology study.
Central Hemodynamic and Thermoregulatory Responses to Food Intake as Potential Biomarkers for Eating Detection: Systematic Review (Preprint)
Authors: Chikwetu Lucy , Vakili Parker , Takais Andrew , Younes Rabih
Published: September 2024

BACKGROUND

Diet-related diseases, such as type 2 diabetes, require strict dietary management to slow down disease progression and call for innovative management strategies. Conventional diet monitoring places a significant memory burden on patients, who may not accurately remember details of their meals and thus frequently falls short in preventing disease progression. Recent advances in sensor and computational technologies have sparked interest in developing eating detection platforms.

OBJECTIVE

This review investigates central hemodynamic and thermoregulatory responses as potential biomarkers for eating detection.

METHODS

We searched peer-reviewed literature indexed in PubMed, Web of Science, and Scopus on June 20, 2022, with no date limits. We also conducted manual searches in the same databases until April 21, 2024. We included English-language papers demonstrating the impact of eating on central hemodynamics and thermoregulation in healthy individuals. To evaluate the overall study quality and assess the risk of bias, we designed a customized tool inspired by the Cochrane assessment framework. This tool has 4 categories: high, medium, low, and very low. A total of 2 independent reviewers conducted title and abstract screening, full-text review, and study quality and risk of bias analysis. In instances of disagreement between the 2 reviewers, a third reviewer served as an adjudicator.

RESULTS

Our search retrieved 11,450 studies, and 25 met our inclusion criteria. Among the 25 included studies, 32% (8/25) were classified as high quality, 52% (13/25) as medium quality, and 16% (4/25) as low quality. Furthermore, we found no evidence of publication bias in any of the included studies. A consistent postprandial increase in heart rate, cardiac output, and stroke volume was observed in at least 95% (heart rate: 19/19, cardiac output: 18/19, stroke volume: 11/11) of the studies that investigated these variables’ responses to eating. Specifically, cardiac output increased by 9%-100%, stroke volume by 18%-41%, and heart rate by 6%-21% across these studies. These changes were statistically significant (P<.05). In contrast, the 8 studies that investigated postprandial thermoregulatory effects displayed grossly inconsistent results, showing wide variations in response with no clear patterns of change, indicating a high degree of variability among these studies.

CONCLUSIONS

Our findings demonstrate that central hemodynamic responses, particularly heart rate, hold promise for wearable-based eating detection, as cardiac output and stroke volume cannot be measured by any currently available noninvasive medical or consumer-grade wearables.

CLINICALTRIAL

PROSPERO CRD42022360600; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=360600
Detection of Sleep Apnea Using Wearable AI: Systematic Review and Meta-Analysis (Preprint)
Authors: Abd-alrazaq Alaa , Aslam Hania , AlSaad Rawan , Alsahli Mohammed , Ahmed Arfan , Damseh Rafat , Aziz Sarah , Sheikh Javaid
Published: September 2024

BACKGROUND

Early detection of sleep apnea, the health condition where airflow either ceases or decreases episodically during sleep, is crucial to initiate timely interventions and avoid complications. Wearable artificial intelligence (AI), the integration of AI algorithms into wearable devices to collect and analyze data to offer various functionalities and insights, can efficiently detect sleep apnea due to its convenience, accessibility, affordability, objectivity, and real-time monitoring capabilities, thereby addressing the limitations of traditional approaches such as polysomnography.

OBJECTIVE

The objective of this systematic review was to examine the effectiveness of wearable AI in detecting sleep apnea, its type, and its severity.

METHODS

Our search was conducted in 6 electronic databases. This review included English research articles evaluating wearable AI’s performance in identifying sleep apnea, distinguishing its type, and gauging its severity. Two researchers independently conducted study selection, extracted data, and assessed the risk of bias using an adapted Quality Assessment of Studies of Diagnostic Accuracy-Revised tool. We used both narrative and statistical techniques for evidence synthesis.

RESULTS

Among 615 studies, 38 (6.2%) met the eligibility criteria for this review. The pooled mean accuracy, sensitivity, and specificity of wearable AI in detecting apnea events in respiration (apnea and nonapnea events) were 0.893, 0.793, and 0.947, respectively. The pooled mean accuracy of wearable AI in differentiating types of apnea events in respiration (normal, obstructive sleep apnea, central sleep apnea, mixed apnea, and hypopnea) was 0.815. The pooled mean accuracy, sensitivity, and specificity of wearable AI in detecting sleep apnea were 0.869, 0.938, and 0.752, respectively. The pooled mean accuracy of wearable AI in identifying the severity level of sleep apnea (normal, mild, moderate, and severe) and estimating the severity score (Apnea-Hypopnea Index) was 0.651 and 0.877, respectively. Subgroup analyses found different moderators of wearable AI performance for different outcomes, such as the type of algorithm, type of data, type of sleep apnea, and placement of wearable devices.

CONCLUSIONS

Wearable AI shows potential in identifying and classifying sleep apnea, but its current performance is suboptimal for routine clinical use. We recommend concurrent use with traditional assessments until improved evidence supports its reliability. Certified commercial wearables are needed for effectively detecting sleep apnea, predicting its occurrence, and delivering proactive interventions. Researchers should conduct further studies on detecting central sleep apnea, prioritize deep learning algorithms, incorporate self-reported and nonwearable data, evaluate performance across different device placements, and provide detailed findings for effective meta-analyses.
Effectiveness of Cognitive Rehabilitation on Cognition and Quality of Life in Chemotherapy-Induced Cognitive Impairment- A Randomized Control Trial Protocol (Preprint)
Authors: Kaple Gayatri Surendra , Qureshi Moh’d Irshad , Raghuveer Raghumahanti , Hullumani V Sharath
Published: September 2024

BACKGROUND

: Abnormal cell growth that can multiply and transfer to other bodily parts is referred to as cancer. Chemotherapy is a common treatment for cancer patients. During or after treatment, patients may have varying degrees of cognitive impairment caused by the drug, which can negatively impact their quality of life. Cognitive impairment brought on by chemotherapy is one of the most frequent side effects that occur both during and after chemotherapy. Cognitive effects after and during chemotherapy have not been addressed in patients.

OBJECTIVE

Cognitive rehabilitation and aerobic exercises are rare approaches that integrate multiple strategies, ultimately improving their cognition and quality of life.

METHODS

The patient of age group of 14-70 years and both male and female subjects diagnosed with any cancer will be going to chemotherapy. There will be a total of 30 individuals in each group during the trial. The sequentially numbered opaque sealed envelope approach will be applied to carry out the randomisation process. The planned outcome measures that will be measured. All the recall strategies, executive function tasks, information processing speed, and attention that is cognitive rehabilitation will be a beneficial therapy for cancer patients with chemotherapy-induced cognitive impairment. The conventional group will be using aerobic exercises and cognitive behavioural therapy with the help of solving cognitive rehabilitation workbook for 4 weeks every day.

RESULTS

As of November 2024, we will enrol 60 participants, and the data collection process will start from November 2024- November 2025. The expected results of the effect of cognitive rehabilitation on cognition and quality of life in chemotherapy-induced cognitive impairment in cancer patients will be significant, and the expected results will be published at the end week of November 2024.

CONCLUSIONS

The study will conclude that cognitive rehabilitation is more effective than cognitive behavioural therapy with an adjunct to aerobic exercise.

CLINICALTRIAL

The study trial is registered under Trial Number: CTRI/2024/04/065805, on date 16/04/2024, the Registration URL is https://ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=102515&EncHid=24678.35134&modid=1&compid=19%27,%27102515det%27
Metastatic Breast Cancer mHealth App to Promote Patient-Provider Communication: Protocol for a Usability and Satisfaction Study (Preprint)
Authors: Alves Thais F. , Crosby Kaitlyn , Horner Ronnie D. , Dai Hongying Daisy , Krishnamurthy Jairam , Cozad Melanie J.
Published: September 2024

BACKGROUND

Mobile health (mHealth) applications can enhance patient-provider communication, playing a crucial role in the diagnosis, treatment, quality of life, and outcomes for patients with metastatic breast cancer (MBC).

OBJECTIVE

This study will evaluate the usability and satisfaction of My MBC Journey, an app designed for metastatic breast cancer, to inform future modifications.

METHODS

We will recruit a prospective, cross-sectional convenience sample of 25 patients with MBC and a sample of 15 members of the care team (i.e., caregivers, nurse navigators, and medical oncologists). Applying iterative, convergent mixed methods, we will conduct qualitative, semi-structured interviews with the patients and care team members. We also will collect quantitative data on usability through app analytics and standardized questionnaires (i.e. Mobile Application Rating Scale (MARS), the Mobile Application rating Scale user version (uMARS), and System Usability Scale.). Qualitative interviews will be audio recorded and analyzed using NVivo® software to identify mHealth implementation themes.

RESULTS

The study’s results will inform future app design modifications and gauge preliminary effect size in support of future evaluations of the app’s efficacy in improving patient-provider communication.

CONCLUSIONS

Our long-term goal is to improve patient-provider communication by developing mHealth apps that empower patients to collect and share clinically relevant, patient-reported information in a timely manner.
Geomorphological and Isotope-Geochemical Methods in Assessing the Gas Potential of a Territory (Using the Example of the Angara-Lena Oil and Gas Region)
Authors: Smirnov Aleksandr , Nourgaliev Danis , Chernova Inna , Ziganshin Eduard
Published: September 2024

The paper examines the geochemical method's effectiveness for assessing the gas potential of territories and prospecting for natural gas fields in combination with data on a territory's neotectonic activity obtained from the digital elevation model analysis in the Eastern Siberia area. Geochemical data include the content of methane and its homologues (C1 – C6), determined by gas chromatography in subsoil samples, as well as the carbon isotope ratio (δ 13C) of the detected methane, measured on an isotope mass spectrometer. The reconstruction of neotectonic activity areas was carried out using a modified morphometric method of digital elevation model analysis. Estimates of the macroscopic fracturing of the sedimentary cover, also caused by neotectonic activity, were obtained from the digital elevation model as the density of lines – primary linear objects expressed in relief, identified using the method of A. A. Zlatopolsky. The information obtained from the digital elevation model allows to identify areas where the probability of gas fields destruction is the highest. A joint analysis of isotope-geochemical data and information on the probable hydrocarbon deposits destruction makes it possible to assess the prospects for the territory's gas content, as well as identify promising areas.
Economic Analysis of Cost of Cultivation and Benefit Cost Ratio of Cauliflower in Response to Solid and Liquid Organic Mannure
Authors: Chawla Gajendra , Hariyana Kuldeep , Khan Salman , Tetarwal Pooja , Rathore Pooja , Meena Deshraj
Published: September 2024

This study evaluates the economic impact of using solid and liquid organic manures on the cultivation of cauliflower, focusing on the cost of cultivation and the benefit-cost (B:C) ratio. The experiment was conducted at technology park CTAE, MPUAT, Udaipur during Rabi season 2021-22 under controlled conditions, where different treatments involving sole and combined application of organic manures (FYM and vermicompost) and four levels of panchagavya were evaluated on cauliflower crop with three replications under factorial RBD design. The analysis involved calculating the total cost of cultivation, including inputs, labour, and other variable costs, and comparing these costs with the net returns obtained from the crop yield. The B ratio was then determined to assess the profitability of each treatment. Result showed that among organic manures application of OM3 treatment (50% RDN through FYM and 50% RDN through vermicompost) as soil application was found recorded maximum net return of Rs. 174791.08. Among different levels of panchagavya, application at 5% concentration as foliar spray gave maximum net return of Rs. 164587.74. The interactive effect of organic manures and panchagavya on net return showed that the combined application of OM3 + PG2 (50 per cent FYM + 50 per cent RDN through Vermicompost + 5 per cent Panchagavya) gave maximum net return of Rs. 206075.16 from cauliflower crop and The combined effect of organic manures and panchagavya on B:C ratio showed that the combined application of OM0 + PG2 (control + 5 per cent Panchagavya) gave maximum B:C ratio of 2.90.
Warren, Monastery, Giant’s Cairn and Nordic Myths—Cultural Memory Writing in The Buried Giant
Authors: Qingyue Zheng
Published: September 2024

Japanese British author Kazuo Ishiguro’s The Buried Giant tells the story of an elderly British couple’s journey of finding their son and reminiscing. He writes the unfinished story between the Britons and Saxons in the post-Arthur era in a fantastical way, focusing on the grand propositions of history, memory and human survival. This article innovatively applies the Assmann couple’s cultural memory theory to analyze the memory writing in The Buried Giant from the dimensions of media, power, and function of cultural memory. The warren, monastery and giant’s cairn in the text are not only the carriers of individual, national and state memories, but also the necessary conditions for the buried stored memories to be awakened under the fog of amnesia. And the Nordic myths, as the cohesive structure in their cultural memory, play a crucial role in reconstructing their own cultural identity. As a result of which, this paper first analyzes the positive role that cultural memory plays in reconstructing identity and healing trauma for individuals, collectives, and nations under the shadow of the Holocaust. Secondly, it explores the writer’s intention to contemplate the survival status of all humanity, comprehend the meaning of life, and call for peace in the context of globalization. Thirdly, it reveals the theme of “facing historical trauma, rejecting negative forgetting, inheriting cultural memory, achieving identity reconstruction, and pursuing harmonious coexistence”.
Por unas ciencias sociales del siglo XXI
Authors: Bokser Liwerant Judit
Published: September 2024

Los seminarios de investigación
Actualmente, en el marco del Programa de Posgrado en Ciencias Políticas y Sociales, hemos compartido la experiencia de sucesivos seminarios de investigación abocados a explorar el significado y alcance de una sociología política para el siglo xxi. En ellos se estudian los desafíos conceptuales que plantean nuevos procesos, tendencias y coyunturas y actúan como un espacio de análisis para abordar tanto temáticas comunes al grupo como abarcar las investigaciones en curso de los participantes. Constituidos por miembros de varias de las comunidades académicas que se dan cita en nuestro posgrado, ellos son los que nos han convocado para dar cauce al dossier de este nuevo número de la Revista.
¿De la milicia a la cautela? Christus en la encrucijada española (1936-1939)
Authors: Ruiz Velasco Barba Rodrigo
Published: September 2024

En un marco de tensión acumulada entre la Iglesia católica y el Estado mexicano, la Guerra Civil española colocó al clero mexicano ante una encrucijada. Este artículo muestra las posturas que en Christus, revista al servicio del episcopado mexicano, fueron expresadas respecto al conflicto peninsular. Puede apreciarse desde el comienzo una clara simpatía hacia la rebelión cívico militar. Asimismo, este escrito pretende reflejar los motivos de tal posicionamiento y el porqué de algunos cambios en su tesitura entre 1936 y 1939. La visión que Christus proyectaba respecto a la lucha en España permite acaso vislumbrar, con el correr de los años, que el discurso católico militante tuvo que contenerse en algún grado, quizá para no comprometer la conciliación entre la jerarquía eclesiástica y el gobierno del general Lázaro Cárdenas.
María Elvira Lacaci o el combate de la fe
Authors: Barnés Vázquez Antonio
Published: September 2024

María Elvira Lacaci fue una poeta española galardonada y antologada. Dos de sus tres poemarios recibieron premios nacionales. Los temas que vertebran su poesía son la relación con Dios y la preocupación social. Fue una de las voces poéticas religiosas más auténticas del siglo XX español. No hay estudios que aborden su poesía completa, aún sin publicar. Este trabajo pretende iniciar un proceso de investigación sistemática de su poesía religiosa, para lo cual se caracterizan sus poemas publicados en antologías de tema religioso. En esta aproximación surge una escritora ascética, que combate por su fe, y mística, que recibe mensajes divinos sin espectáculo, en medio de la calle y de los afanes de su vida cotidiana.
Restorative Justice sebagai Mediasi Penal dalam Penyelesaian Tindak Pidana Kekerasan dalam Rumah Tangga
Authors: Anak Agung Gede Ryan Januar  , I Nyoman Gede Sugiartha  , Ni Made Puspasutari Ujianti
Published: September 2024

Kekerasan dalam rumah tangga tidak hanya menyangkut kekerasan yang dilakukan oleh suami, istri, dan atau terhadap orang yang hanya memiliki hubungan darah tetapi juga seseorang yang bekerja sebagai pekerja rumah tangga yang tetap berada dalam rumah tangga. Rumusan masalah adalah bagaimana pengaturan nilai-nilai Restorative Justice dalam upaya penyelesaian Kekerasan dalam melakukan ketidakadilan Dalam Rumah Tangga? Bagaimana implikasi Mediasi Penal dalam upaya penyelesaian ketidakadilan KDRT yang dilakukan oleh majikan terhadap pekerja rumah tangga.? Analisis materi hukum berdasarkan logika induktif dan deduktif dan disajikan secara deskriptif analisis. Penataan nilai-nilai Restorative Justice dalam upaya penyelesaian Kekerasan melakukan ketidakadilan Dalam Rumah Tangga yaitu dengan penerapan nilai-nilai Restorative Justice melalui mekanisme mediasi penal dapat dijalankan dalam sistem peradilan pidana Indonesia, Dengan demikian penyelesaian melalui mekanisme Mediasi Pidana memperoleh bentuk landasan yurisdiksi yang diharapkan dan jangkauannya. Keadilan dalam menegakkan hukum di masyarakat sehingga penyelesaian atas ketidakadilan KDRT dapat memenuhi rasa keadilan baik pelaku maupun korban (solusi win-win) yang berdampak pada ganti rugi dan penyembuhan terhadap kondisi korban akibat melakukan ketidakadilan yang dilakukan oleh pelaku. diharapkan kepada masyarakat yang memiliki kasus KDRT yang melakukan ketidakadilan masih tergolong ringan melakukan ketidakadilan sehingga diselesaikan melalui jalan keakraban (mediasi) sebelum dilaporkan ke pihak yang berwenang.
Pelaksanaan Perjanjian Kerjasama Antara Ud.Citra Batu Bulan dengan Restoran Nebula Kuta dalam Bidang Supplier Buah dan Sayur
Authors: Ni Kadek Erika Manggala  , Ni Luh Made Mahendrawati  , I Wayan Kartika Jaya Utama
Published: September 2024

Dalam dunia bisnis, suatu kerjasama tidak bisa lepas dari perjanjian yang dibuat.Di Dalam pelaksanaan perjanjian kerjasama antara UD.Citra dengan Restoran Nebula Kuta telah terjadi perselisihan mengenai ketidakseimbangan hak dan kewajiban antara para pihak. Tujuan penelitian ini adalah untuk mengetahui pelaksanaan perjanjian kerjasama antara UD. Citra dengan restoran nebula kuta dalam bidang supplier buah dan sayur dan bagaimana penyelesaian perselisihan apabila terjadi wanprestasi dalam pelaksanaan perjanjian kerjasama antara UD. Citra dengan restoran nebula kuta dalam bidang supplier buah dan sayur.  Metode dalam penelitian ini adalah jenis penelitian hukum empiris. Pendekatan masalah yang digunakan adalah pendekatan fakta. Berdasarkan hasil penelitian UD. Citra dengan  Restoran Nebula Kuta membuat perjanjian berupa kontrak harga dan pembayaran yang harus dilakukan oleh Restoran Nebula Kuta selama 2 (dua) bulan sekali. Terjadinya perselisihan dikarenakan Restoran Nebula Kuta tidak memenuhi prestasi dalam hal ini yaitu tidak melakukan kewajibannya dalam melakukan pembayaran terhadap pihak UD. Citra. Penyelesaian sengketa dilakukan dengan pembuatan surat perjanjian utang piutang.
Penjatuhan Sanksi Pidana Mati Terhadap Pelaku Tindak Pidana Narkotika Terkait Hak Asasi Manusia (Studi Kejaksaan Negeri Badung)
Authors: Ni Putu Eka Noviyanti  , I Nyoman Gede Sugiartha  , I Nyoman Sutama
Published: September 2024

Hukuman mati adalah suatu hukuman yang sangat berat yang bisa berikan kepada para pelaku kejahatan narkotika di Indonesia. Penerapan hukuman ini di Indonesia masih menjadi perbincangan di antara mata pihak setuju dan tidak setuju. Tujuan penelitian ini adalah Untuk memahami bagaimana penjatuhan hukuman pidana mati terhadap pelaku kejahatan pidana narkotika di Indonesia, Untuk mengetahui bagaimana jika pidana mati jika dilihat dari sudut pandang hak asasi manusia, Untuk mengetahui efektivitas penjatuhan sanksi hukuman mati terhadap pelaku kejahatan pidana narkotika di Indonesia. Penelitian ini memakai metode penelitian campuran yaitu gabungan antara metode penelitian empiris yaitu dengan melakukan wawancara ke Kejaksaan Negeri Badung dan normatif yaitu dengan mengacu kepada Undang-undang yang ada di Indonesia. Berdasarkan hasil penelitian menunjukkan keuletan pemerintah dalam hal menanggulangi kasus narkotika dengan memberlakukan hukuman mati bagi pelaku kejahatan pidana narkotika, walaupun yang nyatanya terjadi ialah semakin bertambahnya angka kasus peredaran gelap narkotika di Indonesia setiap tahunnya. Kesimpulan dari penelitian ini adalah bahwa pengenaan suatu hukuman mati bagi pelaku kejahatan narkotika tidak menentang suatu norma tentang perlindungan hak terhadap asasi manusia sehingga dapat dipakai di dalam hukum Indonesia.
Kebijakan Penanggulangan Tindak Pidana Prostitusi Online yang Melibatkan Anak di Bawah Umur (Studi Kasus di Polres Kabupaten Tabanan)
Authors: Kadek Hary Harmawan  , Anak Agung Sagung Laksmi Dewi  , I Made Minggu Widyantara
Published: September 2024

Prostitusi online adalah masalah sosial yang belum diketahui asal-usulnya secara pasti, namun tetap dilakukan baik secara ilegal maupun terbuka. Rumusan masalah yang diangkat dalam penelitian ini mencakup dua pertanyaan pokok: bagaimana penanganan tindak pidana prostitusi online yang dilakukan oleh anak di bawah umur? Apa kebijakan dan tindakan yang dilakukan oleh Polres Tabanan untuk menangani kejahatan prostitusi online? Penelitian ini menggunakan metode empiris. Hasil penelitian menunjukkan bahwa penanggulangan kejahatan terkait prostitusi anak atau anak yang menjadi korban eksploitasi seksual komersial dilakukan melalui berbagai pendekatan, termasuk sosialisasi ketentuan peraturan perundang-undangan yang bertujuan untuk melindungi anak-anak yang rentan terhadap eksploitasi ekonomi dan finansial, pelecehan seksual, pemantauan, pelaporan, dan pemberian sanksi. Selain itu, terlibat pula berbagai instansi pemerintah, korporasi, serikat pekerja, LSM, dan masyarakat dalam upaya penghapusan kekerasan finansial dan/atau seksual terhadap anak. Kebijakan dan upaya Polres Tabanan dalam menghadapi kejahatan prostitusi online, khususnya melalui kebijakan preventif, penindakan, dan tindakan pencegahan, juga telah diidentifikasi dalam penelitian ini.
Perlindungan Hukum terhadap Pencemaran Air Sungai Ayung melalui Kegiatan Pemantauan Lingkungan di Kota Denpasar
Authors: I Made Widagda Dharma Putra  , Ketut Kasta Arya Wijaya  , I Nyoman Sutama
Published: September 2024

Kerusakan dan pencemaran air terjadi, antara lain, sebagai akibat dari penggunaan lahan resapan air yang digunakan sebagai lokasi perumahan untuk pembuangan sisa-sisa kegiatan rumah tangga dan limbah industri ke daerah sekitar atau sungai yang berdekatan. Gaya hidup masyarakat yang tinggal di sekitar sungai dan karakteristik aliran sungai semuanya memiliki dampak yang signifikan pada kualitas aliran sungai tersebut. Tujuan dari penelitian ini adalah untuk menunjukkan contoh pencemaran air sungai dan upaya perlindungan hukum lainnya yang diterapkan di Kota Denpasar, khususnya di Sungai Ayung. Metode penelitian yang digunakan dalam studi ini adalah penelitian hukum empiris. Penelitian empiris adalah salah satu bentuk studi hukum yang mengggunakan data yang diperoleh melalui pengamatan perilaku manusia. Hasil penelitian menunjukkan bahwa izin lingkungan digunakan untuk mengatur pengelolaan dampak lingkungan secara preventif, sebagai salah satu dari berbagai metode dalam penegakan hukum lingkungan. Penegakan hukum lingkungan mencakup tindakan represif, terutama dalam aspek hukum perdata yang terkait dengan pengelolaan lingkungan hidup. Dengan memberlakukan hukuman terhadap mereka yang mencemari lingkungan, pemerintah bertujuan untuk menegakkan hukum.
Perlindungan Hukum Terhadap Hak Kekayaan Intelektual di Lingkungan Provinsi Bali Khususnya Hak Cipta Pada Motif Endek
Authors: Made Kusuma Wardana  , Anak Agung Sagung Laksmi Dewi ,SH.,MH.  , Luh Putu Suryani, SH.,MH.
Published: September 2024

Motif kain tenun Endek di bali sangatlah beragam, tetapi motif kain tersebut belum banyak di daftarkan olehpengrajin endek. Dalam hal ini banyak para pengrajin yang kehilangan motif kain tersebut akibat didaftarkan dandigunakan oleh orang yang kurang bertanggung jawab. Rumusan masalah yang dibahas yaitu bagaimanakahperlindungan hukum terhadap hak kekayaan intelektual yang dilakukan plagiat dan bagaimanakah faktor internaldan eksternal penyebab terjadinya plagiarisme. Penelitian ini merupakan penelitian hukum empiris, perlindunganhukum bagi para pemegang hak kekayaan intelektual apabila terjadi pelanggaran seperti penyalahgunaan atauplagiarisme motif pada endek terbilang sangat gampang untuk dilaporkan. Faktor pelaku plagiarisme disebabkankarena kurangnya sosialisasi dan minimnya kepedulian masyarakat tentang HKI, Dalam hal ini pentingnyakepemilikan HKI agar memiliki perlindungan hukum dan terbebas dari plagiarisme. selain itu masyarakat lebihmementingkan cara pemasaran daripada kepemilikan HKI, kedepannya pemerintah diharapkan lebih gencardalam pelaksanaan sosialisasi pada masyarakat serta pengrajin kain endek agar lebih mengerti tentang pentingyasebuah kepemilikan Hak Cipta.
Antagonistic Property of Selected Herbal Combination for Substitute of Synthetic Antimicrobial Agents
Authors: Karpagam Pechimuthu , Manonmani G
Published: September 2024

The emergence and spread of bacterial strains of multi- drug resistant continues to challenge the healthcare sector of both developed and developing countries. Owing to this problem and concerning the side effects of synthetic antimicrobial agents, the current work was done with medicinal plants. The plant materials such as Terminalia bellerica, Withania somnifera, Madhuca longifolia and Sygyzium cumini was selected based on its potent antimicrobial activity. The best combination of the selected plants was evaluated for their antimicrobial activity. The phytochemical analysis of the selected combination showed the presence of phytoconstituents that are responsible for their biocidal activity. The Minimum inhibitory concentration (MIC) was studied for the selected herbal combination. The results recommend the use of selected plants at their best combination as a substitute to synthetic agents that can effectively prevent the microbial infestation.
Keywords: Antimicrobial activity, Cross infection, Medicinal Plant, MIC, Phytochemical.