bluuebunny/crossref_metadata_2025 huggingface dataset:
Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice
Authors: Griffin Caoimhin S. , Thornbury Keith D. , Hollywood Mark A. , Sergeant Gerard P.
Published: June 2018

Acetylcholine contracts the bladder by binding to muscarinic M3 receptors on the detrusor, leading to Ca2+ influx via voltage-gated Ca2+ channels. The cellular mechanisms linking these events are poorly understood, but studies have suggested that activation of TRPC4 channels could be involved. The purpose of this study was to investigate if spontaneous and cholinergic-mediated contractions of the detrusor were impaired in TRPC4 deficient (TRPC4−/−) mice. Isometric tension recordings were made from strips of wild-type (WT) and TRPC4−/− detrusor. Spontaneous phasic detrusor contractions were significantly smaller in TRPC4−/− mice compared to wild-type, however no difference in response to exogenous application of 60 mM KCl was observed. Cholinergic responses, induced by electric-field stimulation (EFS), bath application of the cholinergic agonist carbachol, or the acetylcholinesterase inhibitor neostigmine were all significantly smaller in TRPC4−/− detrusor strips than wild-type. Surprisingly, the TRPC4/5 inhibitor ML204 reduced EFS and CCh-evoked contractions in TRPC4−/− detrusor strips. However, TRPC5 expression was up-regulated in these preparations and, in contrast to wild-type, EFS responses were reduced in amplitude by the TRPC5 channel inhibitor clemizole hydrochloride. This study demonstrates that TRPC4 channels are involved in spontaneous and cholinergic-mediated contractions of the murine detrusor. TRPC5 expression is up-regulated in TRPC4−/− detrusor strips, and may partially compensate for loss of TRPC4 channels.
Improving truffle mycelium flavour through strain selection targeting volatiles of the Ehrlich pathway
Authors: Vahdatzadeh Maryam , Splivallo Richard
Published: June 2018

Truffles (Tuberspp.) are the fruiting bodies of symbiotic fungi, which are prized food delicacies. The marked aroma variability observed among truffles of the same species has been attributed to a series of factors that are still debated. This is because factors (i.e. genetics, maturation, geographical location and the microbial community colonizing truffles) often co-vary in truffle orchards. Here, we removed the co-variance effect by investigating truffle flavour in axenic cultures of nine strains of the white truffleTuber borchii. This allowed us to investigate the influence of genetics on truffle aroma. Specifically, we quantified aroma variability and explored whether strain selection could be used to improve human-sensed truffle flavour. Our results illustrate that aroma variability among strains is predominantly linked to amino acid catabolism through the Ehrlich pathway, as confirmed by13C labelling experiments. We furthermore exemplified through sensory analysis that the human nose is able to distinguish among strains and that sulfur volatiles derived from the catabolism of methionine have the strongest influence on aroma characteristics. Overall, our results demonstrate that genetics influences truffle aroma much more deeply than previously thought and illustrate the usefulness of strain selection for improving truffle flavour.
Exotic Spartina alterniflora invasion increases CH4 while reduces CO2 emissions from mangrove wetland soils in southeastern China
Authors: Gao Gui Feng , Li Peng Fei , Shen Zhi Jun , Qin Ying Ying , Zhang Xi Min , Ghoto Kabir , Zhu Xue Yi , Zheng Hai Lei
Published: June 2018

Mangroves are critical in global carbon budget while vulnerable to exotic plant invasion. Spartina alterniflora, one of typical salt marsh plant grows forcefully along the coast of China, has invaded the native mangrove habitats in Zhangjiang Estuary. However, the effects of S. alterniflora invasion on soil carbon gases (CH4 and CO2) emission from mangroves are not fully understood. Accordingly, we conducted a field experiment to investigate the soil CH4 and CO2 emission during growing seasons in 2016 and 2017 at four adjacent wetlands, namely bare mudflat (Mud), Kandelia obovata (KO), Avicennia marina (AM) and S. alterniflora (SA). Potential methane production (PMP), potential methane oxidation (PMO), functional microbial abundance and soil biogeochemical properties were measured simultaneously. Our results indicate that S. alterniflora invasion could dramatically increase soil CH4 emissions mainly due to the enhancement in PMP which facilitated by soil EC, MBC, TOC and mcrA gene abundance. Additionally, S. alterniflora invasion decreases soil CO2 emission. Both heterotrophic microbial respiration (16S rRNA) and methane oxidation (pmoA and ANME-pmoA) are responsible for CO2 emission reduction. Furthermore, S. alterniflora invasion greatly increases GWP by stimulating CH4 emissions. Thus, comparing with mangroves, invasive S. alterniflora significantly (p < 0.001) increases CH4 emission while reduces CO2 emission.
Extremely High Frequency Electromagnetic Fields Facilitate Electrical Signal Propagation by Increasing Transmembrane Potassium Efflux in an Artificial Axon Model
Authors: D’Agostino Simona , Della Monica Chiara , Palizzi Eleonora , Di Pietrantonio Fabio , Benetti Massimiliano , Cannatà Domenico , Cavagnaro Marta , Sardari Dariush , Stano Pasquale , Ramundo-Orlando Alfonsina
Published: June 2018

Among the many biological effects caused by low intensity extremely high frequency electromagnetic fields (EHF-EMF) reported in the literature, those on the nervous system are a promising area for further research. The mechanisms by which these fields alter neural activity are still unclear and thus far there appears to be no frequency dependence regarding neuronal responses. Therefore, properin vitromodels for preliminary screening studies of the interaction between neural cells with EMF are needed. We designed an artificial axon model consisting of a series of parallel RC networks. Each RC network contained an aqueous solution of lipid vesicles with a gradient of potassium (K+) concentration as the functional element. We investigated the effects of EHF-EMF (53.37 GHz–39 mW) on the propagation of the electric impulse. We report that exposure to the EHF-EMF increases the amplitude of electrical signal by inducing a potassium efflux from lipid vesicles. Further, exposure to the EHF-EMF potentiates the action of valinomycin – a K+carrier – increasing the extent of K+transport across the lipid membrane. We conclude that exposure to the EHF-EMF facilitates the electrical signal propagation by increasing transmembrane potassium efflux, and that the model presented is promising for future screening studies of different EMF frequency spectrum bands.
The Emergence of Animal Management in the Southern Levant
Authors: Munro Natalie D. , Bar-Oz Guy , Meier Jacqueline S. , Sapir-Hen Lidar , Stiner Mary C. , Yeshurun Reuven
Published: June 2018

Our compilation of zooarchaeological data from a series of important archaeological sites spanning the Epipaleolithic through Pre-Pottery Neolithic B periods in the Mediterranean Hills of the southern Levant contributes to major debates about the beginnings of ungulate management in Southwest Asia. The data support an onset of ungulate management practices by the Early PPNB (10,500–10,000 cal. BP), more than 500 years earlier than previously thought for this region. There is a clear developmental connection between reduced hunting intensity and the uptake of ungulate management, confirming that this process began in response to local, density-dependent demographic factors. The early process of goat domestication in the southern Levant appears to have been overwhelmingly local. This may have been true for cattle and pigs as well. Nevertheless, the loose synchrony of animal management trends across Southwest Asia was undoubtedly enabled by large-scale social networks that transmitted knowledge. The results add to growing evidence that animal management processes followed multiple regional evolutionary pathways within the Fertile Crescent.
No yield penalty under favorable conditions paving the way for successful adoption of flood tolerant rice
Authors: Dar Manzoor H. , Zaidi Najam W. , Waza Showkat A. , Verulkar Satish B. , Ahmed T. , Singh P. K. , Roy S. K. Bardhan , Chaudhary Bedanand , Yadav Rambaran , Islam Mirza Mofazzal , Iftekharuddaula Khandakar M. , Roy J. K. , Kathiresan R. M. , Singh B. N. , Singh Uma S. , Ismail Abdelbagi M.
Published: June 2018

Flooding is one of the major constraints for rice production in rainfed lowlands, especially in years and areas of high rainfall. Incorporating the Sub1 (Submergence1) gene into high yielding popular varieties has proven to be the most feasible approach to sustain rice production in submergence-prone areas. Introgression of this QTL into popular varieties has resulted in considerable improvement in yield after flooding. However, its impact under non-flooded conditions or years have not been thoroughly evaluated which is important for the farmers to accept and adopt any new version of their popular varieties. The present study was carried out to evaluate the effect of Sub1 on grain yield of rice in different genetic backgrounds, under non-submergence conditions, over years and locations. The study was carried out using head to head trials in farmer’s fields, which enable the farmers to more accurately compare the performance of Sub1 varieties with their recurrent parents under own management. The data generated from different head to head trials revealed that the grain yield of Sub1 varieties was either statistically similar or higher than their non-Sub1 counterparts under non-submergence conditions. Thus, Sub1 rice varieties show no instance of yield penalty of the introgressed gene.
MS analysis of a dilution series of bacteria:phytoplankton to improve detection of low abundance bacterial peptides
Authors: Timmins-Schiffman Emma , Mikan Molly P. , Ting Ying Sonia , Harvey H. Rodger , Nunn Brook L.
Published: June 2018

Assigning links between microbial activity and biogeochemical cycles in the ocean is a primary objective for ecologists and oceanographers. Bacteria represent a small ecosystem component by mass, but act as the nexus for both nutrient transformation and organic matter recycling. There are limited methods to explore the full suite of active bacterial proteins largely responsible for degradation. Mass spectrometry (MS)-based proteomics now has the potential to document bacterial physiology within these complex systems. Global proteome profiling using MS, known as data dependent acquisition (DDA), is limited by the stochastic nature of ion selection, decreasing the detection of low abundance peptides. The suitability of MS-based proteomics methods in revealing bacterial signatures outnumbered by phytoplankton proteins was explored using a dilution series of pure bacteria (Ruegeria pomeroyi) and diatoms (Thalassiosira pseudonana). Two common acquisition strategies were utilized: DDA and selected reaction monitoring (SRM). SRM improved detection of bacterial peptides at low bacterial cellular abundance that were undetectable with DDA from a wide range of physiological processes (e.g. amino acid synthesis, lipid metabolism, and transport). We demonstrate the benefits and drawbacks of two different proteomic approaches for investigating species-specific physiological processes across relative abundances of bacteria that vary by orders of magnitude.
Testing for Sufficient-Cause Interactions in Case-Control Studies of Non-Rare Diseases
Authors: Lin Jui-Hsiang , Lee Wen-Chung
Published: June 2018

Sufficient-cause interaction (also called mechanistic interaction or causal co-action) has received considerable attention recently. Two statistical tests, the ‘relative excess risk due to interaction’ (RERI) test and the ‘peril ratio index of synergy based on multiplicativity’ (PRISM) test, were developed specifically to test such an interaction in cohort studies. In addition, these two tests can be applied in case–control studies for rare diseases but are not valid for non-rare diseases. In this study, we proposed a method to incorporate the information of disease prevalence to estimate the perils of particular diseases. Moreover, we adopted the PRISM test to assess the sufficient-cause interaction in case–control studies for non-rare diseases. The Monte Carlo simulation showed that our proposed method can maintain reasonably accurate type I error rates in all situations. Its powers are comparable to the odds-scale PRISM test and far greater than the risk-scale RERI test and the odds-scale RERI test. In light of its desirable statistical properties, we recommend using the proposed method to test for sufficient-cause interactions between two binary exposures in case–control studies.
Mesenchymal stem cell-mediated Notch2 activation overcomes radiation-induced injury of the hematopoietic system
Authors: Kim Areumnuri , Shim Sehwan , Kim Min-Jung , Myung Jae Kyung , Park Sunhoo
Published: June 2018

Radiation exposure severely damages the hematopoietic system. Although several radio-protectors have been proposed to prevent radiation-induced damage, most agents have limited efficacy. In the present study, we investigated whether mesenchymal stem cells (MSCs) could contribute to the expansion of hematopoietic cells and mitigate radiation-induced hematopoietic injury in vitro and in vivo. We found that co-culture with MSCs promoted hematopoietic progenitor/stem cell (HPSCs) maintenance by providing a bone marrow-like microenvironment. In addition, we showed that MSCs prevented radiation-induced damage to HPSCs, as evidenced by the lack of DNA damage and apoptosis. Intravenously injected MSCs rapidly migrated to the bone marrow (BM) and prevented loss of BM cellularity, which reduced lethality and ameliorated pancytopenia in the BM of whole body-irradiated mice. We demonstrated that MSC-derived Jagged1 attenuated radiation-induced cytotoxicity of HPSCs, and that this was mediated by Notch signaling and expression of downstream proteins Bcl2 and p63 in HPSCs. In addition, Notch2 depletion significantly reduced the MSC-mediated radio-protective effect in human- and mouse-derived HPSCs. Collectively, our data show that activation of Notch and its associated downstream signaling pathways prevent radiation-induced hematopoietic injury. Therefore, enhancing Jagged1-Notch2 signaling could provide therapeutic benefit by protecting the hematopoietic system against damage after radiation.
Nitric Oxide Controls Constitutive Freezing Tolerance in Arabidopsis by Attenuating the Levels of Osmoprotectants, Stress-Related Hormones and Anthocyanins
Authors: Costa-Broseta Álvaro , Perea-Resa Carlos , Castillo Mari-Cruz , Ruíz M. Fernanda , Salinas Julio , León José
Published: June 2018

Plant tolerance to freezing temperatures is governed by endogenous constitutive components and environmental inducing factors. Nitric oxide (NO) is one of the endogenous components that participate in freezing tolerance regulation. A combined metabolomic and transcriptomic characterization of NO-deficientnia1,2noa1–2mutant plants suggests that NO acts attenuating the production and accumulation of osmoprotective and regulatory metabolites, such as sugars and polyamines, stress-related hormones, such as ABA and jasmonates, and antioxidants, such as anthocyanins and flavonoids. Accordingly, NO-deficient plants are constitutively more freezing tolerant than wild type plants.
Ordering of Hollow Ag-Au Nanospheres with Butterfly Wings as a Bio-template
Authors: Guan Yu , Su Huilan , Yang Chengzhi , Wu Lingling , Chen Shikun , Gu Jiajun , Zhang Wang , Zhang Di
Published: June 2018

A biological template strategy is implemented for the fabrication of hollow noble metal composite nanospheres within the ordered array nanostructures by introducing butterfly wings to some convenient technique procedure. Butterfly wings are activated by ethylenediamine to increase the reactive sites on the chitin component, on which Ag nanoparticles are in situ formed and serve as “seeds” to direct further incorporation during the following impregnation procedure. Butterfly wings could function as bio-substrate to provide an ordered array and regulate the synthesis process by providing active reaction sites (e.g. -CONH- and -OH). Thus, hollow Ag-Au nanospheres are loaded on the wings’ surface layer and inside the ordered array nanostructures homogeneously, which would have potential applications in surface enhanced Raman scattering (SERS).
Aberration correction considering curved sample surface shape for non-contact two-photon excitation microscopy with spatial light modulator
Authors: Matsumoto Naoya , Konno Alu , Inoue Takashi , Okazaki Shigetoshi
Published: June 2018

In this paper, excitation light wavefront modulation is performed considering the curved sample surface shape to demonstrate high-quality deep observation using two-photon excitation microscopy (TPM) with a dry objective lens. A large spherical aberration typically occurs when the refractive index (RI) interface between air and the sample is a plane perpendicular to the optical axis. Moreover, the curved sample surface shape and the RI mismatch cause various aberrations, including spherical ones. Consequently, the fluorescence intensity and resolution of the obtained image are degraded in the deep regions. To improve them, we designed a pre-distortion wavefront for correcting the aberration caused by the curved sample surface shape by using a novel, simple optical path length difference calculation method. The excitation light wavefront is modulated to the pre-distortion wavefront by a spatial light modulator incorporated in the TPM system before passing through the interface, where the RI mismatch occurs. Thus, the excitation light is condensed without aberrations. Blood vessels were thereby observed up to an optical depth of 2,000 μm in a cleared mouse brain by using a dry objective lens.
Geriatric influenza death (GID) score: a new tool for predicting mortality in older people with influenza in the emergency department
Authors: Chung Jui-Yuan , Hsu Chien-Chin , Chen Jiann-Hwa , Chen Wei-Lung , Lin Hung-Jung , Guo How-Ran , Huang Chien-Cheng
Published: June 2018

Although influenza may cause death in the geriatric population, the best method for predicting mortality in this population is still unclear. We retrospectively recruited older people (≥65 yr) with influenza visiting the emergency department (ED) of a medical center between January 1, 2010, and December 31, 2015. We performed univariate and multivariate logistic regression to identify independent mortality predictors and then developed a prediction score. Four hundred nine older ED patients with a nearly equal sex ratio were recruited. Five independent mortality predictors were identified: severe coma (Glasgow Coma Scale score ≤8), past histories of cancer and coronary artery disease, elevated C-reactive protein levels (>10 mg/dl), and bandemia (>10% band cells). We divided the patients into three mortality risk and disposition groups: (1) low risk (1.1%; 95% confidence interval [CI], 0.5–3.0%); (2) moderate risk (16.7%; 95% CI, 9.3–28.0%); and (3) high risk (40%; 95% CI, 19.8–64.2%). The area under the receiver operating characteristic curve and the Hosmer-Lemeshow goodness of fit of the GID score were 0.86 and 0.578, respectively. The GID score is an efficient and simple tool for predicting mortality in older ED patients with influenza. Further studies are warranted to validate its use.
Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis
Authors: Khosravi Niloufar , Maeda Azusa , DaCosta Ralph S. , Davies John E.
Published: June 2018

Nanosurfaces have improved clinical osseointegration by increasing bone/implant contact. Neovascularization is considered an essential prerequisite to osteogenesis, but no previous reports to our knowledge have examined the effect of surface topography on the spatio-temporal pattern of neovascularization during peri-implant healing. We have developed a cranial window model to study peri-implant healing intravitally over clinically relevant time scales as a function of implant topography. Quantitative intravital confocal imaging reveals that changing the topography (but not chemical composition) of an implant profoundly affects the pattern of peri-implant neovascularization. New vessels develop proximal to the implant and the vascular network matures sooner in the presence of an implant nanosurface. Accelerated angiogenesis can lead to earlier osseointegration through the delivery of osteogenic precursors to, and direct formation of bone on, the implant surface. This study highlights a critical aspect of peri-implant healing, but also informs the biological rationale for the surface design of putative endosseous implant materials.
PubMed Phrases, an open set of coherent phrases for searching biomedical literature
Authors: Kim Sun , Yeganova Lana , Comeau Donald C. , Wilbur W. John , Lu Zhiyong
Published: June 2018

In biomedicine, key concepts are often expressed by multiple words (e.g., ‘zinc finger protein’). Previous work has shown treating a sequence of words as a meaningful unit, where applicable, is not only important for human understanding but also beneficial for automatic information seeking. Here we present a collection of PubMed® Phrases that are beneficial for information retrieval and human comprehension. We define these phrases as coherent chunks that are logically connected. To collect the phrase set, we apply the hypergeometric test to detect segments of consecutive terms that are likely to appear together in PubMed. These text segments are then filtered using the BM25 ranking function to ensure that they are beneficial from an information retrieval perspective. Thus, we obtain a set of 705,915 PubMed Phrases. We evaluate the quality of the set by investigating PubMed user click data and manually annotating a sample of 500 randomly selected noun phrases. We also analyze and discuss the usage of these PubMed Phrases in literature search.
Early and rapid detection of UCHL1 in the serum of brain-trauma patients: a novel gold nanoparticle-based method for diagnosing the severity of brain injury
Authors: Singh Gyaninder Pal , Nigam Richa , Tomar Gaurav Singh , Monisha Mohan , Bhoi Sanjeev Kumar , S Arulselvi , Sengar Kangana , Akula Deepa , Panta Prashanth , Anindya Roy
Published: June 2018

We provide a gold nanoparticle-based method for traumatic brain injury diagnosis.
Ochratoxin A enhanced detection of cytochrome c with an aptamer-based microcantilever sensor
Authors: Chen Xuejuan , Li Chen , Pan Yangang , Zhang Bailin
Published: June 2018

We developed a microcantilever signal amplification strategy for detecting cytochrome c based on the interaction of cytochrome c with ochratoxin A.
Sodium polytungstate as gravity separating fluid for polymeric blasting media evaluation
Authors: Helbig Patric , Pitt Cheryll D.
Published: June 2018

Quality assessment of Plastic Blast Media (PBM) in order to determine heavy and light particulate contamination has been carried out traditionally using gravity separation in a medium prepared using 1,1,2-trifluorotrichloroethane (TFTCE) as high density compound.
Novel gradient-diameter magnetic nanowire arrays with unconventional magnetic anisotropy behaviors
Authors: Wang Jing , Zuo Zhili , Huang Liang , Warsi Muhammad Asif , Xiao John Q. , Hu Jun
Published: June 2018

Gradient-diameter magnetic nanowires exhibited tailorable magnetic anisotropy that can be used to switch magnetic nanowires easily and unconventional temperature-dependent coercivity.
Cleavage of BN triple bonds by main group reagents
Authors: Winner Lena , Hermann Alexander , Bélanger-Chabot Guillaume , González-Belman Oscar F. , Jiménez-Halla J. Oscar C. , Kelch Hauke , Braunschweig Holger
Published: June 2018

A silylene and a 1,2-diaminoalkyne respectively cleave the strong BN triple bond in iminoboranes.
Charge designable and tunable GFP as a target pH-responsive carrier for intracellular functional protein delivery and tracing
Authors: Hu Shanfang , Chen Xiaoye , Lei Chunyang , Tang Rui , Kang Wenyuan , Deng Honghua , Huang Yan , Nie Zhou , Yao Shouzhuo
Published: June 2018

A charge designable and tunable green fluorescent protein (GFP)-based protein delivery strategy was proposed.
Electrochemical sensing of attomolar miRNA combining cascade strand displacement polymerization and reductant-mediated amplification
Authors: Miao Peng , Jiang Yiting , Zhang Tian , Huang Yue , Tang Yuguo
Published: June 2018

An electrochemical biosensor for miRNA assay with attomolar sensitivity was developed based on cascade strand displacement polymerization and reductant-mediated amplification.
Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H
Authors: Yang Fengyuan , Zheng Guoxun , Fu Tingting , Li Xiaofeng , Tu Gao , Li Ying Hong , Yao Xiaojun , Xue Weiwei , Zhu Feng
Published: June 2018

The recently developed pyrrolyl diketo acid scaffold targeting both HIV-1 IN and RNase H is beneficial to counteract the failure of anti-HIV treatment due to drug resistance.
A first-principles study of the electrically tunable band gap in few-layer penta-graphene
Authors: Wang Jinjin , Wang Zhanyu , Zhang R. J. , Zheng Y. X. , Chen L. Y. , Wang S. Y. , Tsoo Chia-Chin , Huang Hung-Ji , Su Wan-Sheng
Published: June 2018

Our calculations show that the electronic properties of few-layer penta-graphene can obviously be modulated through an external electric field.
Ab initio molecular dynamics of atomic-scale surface reactions: insights into metal organic chemical vapor deposition of AlN on graphene
Authors: Sangiovanni D. G. , Gueorguiev G. K. , Kakanakova-Georgieva A.
Published: June 2018

Density-functional molecular dynamics simulations provide plausible interpretations of atomistic and electronic processes responsible for delivery of Al, C adatoms, and C–Al, CHx, AlNH2 admolecules on pristine graphene via precursor/surface reactions.
A low temperature investigation of the gas-phase N(2D) + NO reaction. Towards a viable source of N(2D) atoms for kinetic studies in astrochemistry
Authors: Nuñez-Reyes Dianailys , Hickson Kevin M.
Published: June 2018

The gas-phase reaction of metastable atomic nitrogen N(2D) with nitric oxide has been investigated over the 296–50 K temperature range using a supersonic flow reactor.
Measuring the size and complex refractive index of an aqueous aerosol particle using electromagnetic heating and cavity-enhanced Raman scattering
Authors: Rafferty Aidan , Preston Thomas C.
Published: June 2018

We describe a dual-beam optical trap that can simultaneously determine the complex refractive index and the radius of weakly absorbing aerosol particles.
Single-site and nano-confined photocatalysts designed in porous materials for environmental uses and solar fuels
Authors: Yamashita Hiromi , Mori Kohsuke , Kuwahara Yasutaka , Kamegawa Takashi , Wen Meicheng , Verma Priyanka , Che Michel
Published: June 2018

This review presents the progress in the design of single-site and nano-confined photocatalysts in porous materials for environmental remediation and solar fuel production.
N,1,4-Tri(4-alkoxy-2-hydroxybenzyl)-DAZA: efficient one-pot synthesis and labelling with68Ga for PET liver imagingin ovo
Authors: Greiser Julia , Kühnel Christian , Görls Helmar , Weigand Wolfgang , Freesmeyer Martin
Published: June 2018

In ovoPET/CT liver imaging in ostrich eggs with novel hepatotrope68Ga tracers based on the DAZA scaffold.
An air and moisture tolerant iminotrihydroquinoline-ruthenium(ii) catalyst for the transfer hydrogenation of ketones
Authors: Li Jiaoyan , Ma Yingmiao , Wang Zheng , Liu Qingbin , Solan Gregory A. , Ma Yanping , Sun Wen-Hua
Published: June 2018

Both amine- and imine-containing E and F are highly effective in the transfer hydrogenation of a wide range of ketones with F significantly operating in bench quality 2-propanol and in vessels open to the air.
Immobilization of hydrous iron oxides in porous alginate beads for arsenic removal from water
Authors: Sigdel Abinashi , Lim Joowan , Park Jeongwon , Kwak Hyoeun , Min Sojin , Kim Keehong , Lee Hosung , Nahm Chang Hyun , Park Pyung-Kyu
Published: June 2018

For removal of arsenic in the aqueous phase, hydrous iron oxides (HIOs) were immobilized in alginate beads with enhanced porosity (designated as HIO-P-alginate beads).
New completely renewable biofuels: formulations and engine tests on an unmodified up-to-date diesel engine
Authors: Brock Damian , Koder Alexander , Rabl Hans-Peter , Touraud Didier , Kunz Werner
Published: June 2018

A new concept for the formulation of completely green biofuels with vegetable oils as the main component and applicable in unmodified up-to-date diesel engines was developed.
Sequential (3 + 2) cycloaddition and (5 + n) annulation for modular synthesis of dihydrobenzoxazines, tetrahydrobenzoxazepines and tetrahydrobenzoxazocines
Authors: Muthengi Alex , Zhang Xiaofeng , Dhawan Gagan , Zhang Wensheng , Corsini Francesca , Zhang Wei
Published: June 2018

A method for the (3 + 2) cycloaddition of azomethine ylides followed by a (5 + n) double SN2 substitution is introduced for the modular synthesis of dihydrobenzoxazines, tetrahydrobenzoxazepines and tetrahydrobenzoxazocines.
Synthesis of high-density aviation fuels with methyl benzaldehyde and cyclohexanone
Authors: Xu Jilei , Li Ning , Li Guangyi , Han Fengan , Wang Aiqin , Cong Yu , Wang Xiaodong , Zhang Tao
Published: June 2018

Jet fuel range tricyclic alkanes were first selectively synthesized with methyl benzaldehyde and cyclohexanone which can be derived from lignocellulose.
An integrated global regulatory network of hematopoietic precursor cell self-renewal and differentiation
Authors: You Yanan , Cuevas-Diaz Duran Raquel , Jiang Lihua , Dong Xiaomin , Zong Shan , Snyder Michael , Wu Jia Qian
Published: June 2018

We integrated datasets from transcriptomic, proteomic, epigenomic, and protein–protein interaction levels to build a global regulatory network to better characterize the mechanisms underlying HSPCs self-renewal.
Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy
Authors: Hao Nanjing , Nie Yuan , Shen Ting , Zhang John X. J.
Published: June 2018

A microfluidics-enabled strategy for the controllable synthesis of immunomagnetic nanomaterials was developed, and the shape-dependent screening efficiency of CTCs was investigated.
Novel antitumor copper(ii) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity
Authors: Morelli Maria Beatrice , Amantini Consuelo , Santoni Giorgio , Pellei Maura , Santini Carlo , Cimarelli Cristina , Marcantoni Enrico , Petrini Marino , Del Bello Fabio , Giorgioni Gianfabio , Piergentili Alessandro , Quaglia Wilma
Published: June 2018

An NMDA receptor ligand was linked to bifunctionalizable species to form copper(ii) complexes, showing antitumor activity through synergistic action mechanisms.
Solvent effects on the electrical and magnetic spectroscopic properties of azo-enaminone derivatives in methanol and in water
Authors: Oliveira Leonardo Bruno Assis , Adriano Júnior Luizmar , Colherinhas Guilherme
Published: June 2018

We have investigated the solvent effects on the nonlinear and spectroscopic optical properties of some azo-enaminone molecules in the gas phase and in methanol and water solutions.
Nano-dispersed platinum(0) in organically modified silicate matrices as sustainable catalysts for a regioselective hydrosilylation of alkenes and alkynes
Authors: Duke Brett J. , Akeroyd Evan N. , Bhatt Shreeja V. , Onyeagusi Chibueze I. , Bhatt Shreya V. , Adolph Brandy R. , Fotie Jean
Published: June 2018

Comparative analysis of the catalytic effect of Pt(0) nano-dispersed in siloxane matrices on the hydrosilylation of alkenes and alkynes.
Isocyanide based multicomponent click reactions: a green and improved synthesis of 1-substituted 1H-1,2,3,4-tetrazoles
Authors: Pharande Shrikant G. , Rentería-Gómez Manuel A. , Gámez-Montaño Rocío
Published: June 2018

An improved synthesis of 1-substituted 1H-1,2,3,4-tetrazoles via a novel isocyanide based multicomponent click reaction under ultrasound assisted mild, solvent, catalyst and column-free conditions has been developed.
Breaking the Nd3+-sensitized upconversion nanoparticles myth about the need of onion-layered structures
Authors: Estebanez Nestor , Ferrera-González Juan , Francés-Soriano Laura , Arenal Raul , González-Béjar María , Pérez-Prieto Julia
Published: June 2018

Excitation at 800 nm effectively triggers the upconversion emission of NaYF4:Yb,Er(Tm)/NaYF4 core–shell nanoparticles with Nd3+ anchored at the organic capping by using cucurbituril[7] as an adhesive.
Differential effects of graphene materials on the metabolism and function of human skin cells
Authors: Frontiñán-Rubio Javier , Gómez M. Victoria , Martín Cristina , González-Domínguez Jose M. , Durán-Prado Mario , Vázquez Ester
Published: June 2018

Low doses of GO or FLG produce a metabolic remodeling that differentially affects human skin cell death and motility.
Effects of geometry and composition of soft polymer films embedded with nanoparticles on rates for optothermal heat dissipation
Authors: Roper D. Keith , Berry Keith R. , Dunklin Jeremy R. , Chambers Caitlyn , Bejugam Vinith , Forcherio Gregory T. , Lanier Megan
Published: June 2018

Herein, we show the size and concentration of irradiated (green arrows) nanoparticles (gold dots) in soft matter (dashed lines) define the transient rate of conductive, convective, and radiative heating (red arrows).
Enhanced and preferential internalization of lipid nanocapsules into human glioblastoma cells: effect of a surface-functionalizing NFL peptide
Authors: Karim Reatul , Lepeltier Elise , Esnault Lucille , Pigeon Pascal , Lemaire Laurent , Lépinoux-Chambaud Claire , Clere Nicolas , Jaouen Gérard , Eyer Joel , Piel Géraldine , Passirani Catherine
Published: June 2018

Preferential internalization into GBM cells and significant decrease of the tumor volume by functionalized LNCs.
An efficient dye-sensitized NIR emissive lanthanide nanomaterial and its application in fluorescence-guided peritumoral lymph node dissection
Authors: Liu Qingyun , Zou Xianmei , Shi Yibing , Shen Bin , Cao Cong , Cheng Shengming , Feng Wei , Li Fuyou
Published: June 2018

Through combining Cy7 and NaYbF4@NaYF4:60%Nd together to form a dye-sensitized system, the near-infrared emission intensity of Yb was significantly enhanced.
Synergistic combination chemotherapy using carrier-free celastrol and doxorubicin nanocrystals for overcoming drug resistance
Authors: Xiao Yating , Liu Jing , Guo Mengyu , Zhou Huige , Jin Jun , Liu Jiaming , Liu Ying , Zhang Zhanjun , Chen Chunying
Published: June 2018

Celastrol and doxorubicin are self-assembled into carrier-free and biocompatible nanoparticles via a green method, which enhance synergistic combination chemotherapy and overcome drug resistance.
Dynamic strain in gold nanoparticle supported graphene induced by focused laser irradiation
Authors: Pálinkás András , Kun Péter , Koós Antal A. , Osváth Zoltán
Published: June 2018

Gold nanoparticles are formed and dynamic strain is induced in graphene by local annealing with a focused laser beam.
Native DNA electronics: is it a matter of nanoscale assembly?
Authors: D'Agostino Luciano
Published: June 2018

Polyamines and phosphates interact in the cell nucleus to form cyclic modules (the nuclear aggregates of polyamines) that wrap the entire DNA. The resulting nanotubes have semiconducting features, and potentially, both shuttle the binding proteins and twist the histones.
Tumor-targeted and nitric oxide-generated nanogels of keratin and hyaluronan for enhanced cancer therapy
Authors: Sun Zhe , Yi Zeng , Cui Xinxing , Chen Xiangyu , Su Wen , Ren Xiaoxiang , Li Xudong
Published: June 2018

Tumor-targeted and nitric oxide-generated nanogels based on human hair keratin and hyaluronan for enhanced cancer therapy.
Ratiometric photoacoustic nanoprobes for monitoring and imaging of hydrogen sulfide in vivo
Authors: Ma Teng , Zheng Judun , Zhang Tao , Xing Da
Published: June 2018

An activatable nanoprobe has been developed for switch-on ratiometric photoacoustic detection and imaging of H2S in vitro and in vivo.
Imaging the magnetic structures of artificial quasicrystal magnets using resonant coherent diffraction of circularly polarized X-rays
Authors: Sung Daeho , Jung Chulho , Cho Byeong-Gwan , Jo Wonhyuk , Han Hee-Sung , Lee Ki-Suk , Bhat Vinayak , Farmer Barry , De Long L. E. , Lee Ki Bong , Keavney D. J. , Lee Dong Ryeol , Song Changyong
Published: June 2018

Unraveling nanoscale spin structures has long been an important activity addressing various scientific interests, that are also readily adaptable to technological applications.
Supramolecular alternate donor–acceptor copolymers mediated by Pt⋯Pt metal–metal interactions and their photocatalytic applications
Authors: Gao Zhao , Li Zijian , Gao Zongchun , Wang Feng
Published: June 2018

Precise arrangement of the aromatic donor–acceptor units is of paramount importance to dictate the performance of multi-component π-functional materials.
Optically controlled dielectric properties of single-walled carbon nanotubes for terahertz wave applications
Authors: Smirnov Serguei , Anoshkin Ilya V. , Demchenko Petr , Gomon Daniel , Lioubtchenko Dmitri V. , Khodzitsky Mikhail , Oberhammer Joachim
Published: June 2018

The complex dielectric constant of single-walled carbon nanotubes is tuned in the terahertz frequency range under light illumination.
New insights into the electrochemistry of magnesium molybdate hierarchical architectures for high performance sodium devices
Authors: Minakshi Manickam , Mitchell David R. G. , Munnangi Anji Reddy , Barlow Anders J. , Fichtner Maximilian
Published: June 2018

A hierarchical plate-like magnesium molybdate anode for sodium devices for storing energy with high rate performance and excellent capacity retention.
Stabilized monolayer 1T MoS2 embedded in CoOOH for highly efficient overall water splitting
Authors: Shang Bo , Ma Pengfei , Fan Jinchang , Jiao Lin , Liu Zijian , Zhang Zheyu , Chen Nuo , Cheng Zhiliang , Cui Xiaoqiang , Zheng Weitao
Published: June 2018

We report for the first time the synthesis of stabilized vertical monolayer 1T MoS2via a facile one-pot strategy.
Cytidine- and guanosine-based nucleotide–lipids
Authors: Alies Bruno , Ouelhazi Mohamed A. , Patwa Amit , Verget Julien , Navailles Laurence , Desvergnes Valérie , Barthélémy Philippe
Published: June 2018

A nucleotide–lipids family featuring the four natural nucleobases was explored through their self-assembly properties.
Unprecedented synthesis of 1,2,3-triazolo-cinnolinone via Sonogashira coupling and intramolecular cyclization
Authors: Kumar Avnish , Tiwari Dharmendra Kumar , Sridhar Balasubramanian , Likhar Pravin R.
Published: June 2018

An unprecedented copper mediated one-pot sequential synthesis of 1,2,3-triazolo cinnolinone derivatives from 2-halo-phenyl triazoles and terminal alkynes has been reported.
Polyurethane with an ionic liquid crosslinker: a new class of super shape memory-like polymers
Authors: Behera Prasanta Kumar , Mondal Prantik , Singha Nikhil K.
Published: June 2018

Polyurethane (PU) with an ionic liquid crosslinker (with a unique double network having a combination of covalent as well as ionic crosslinking) showed excellent shape-recovery as well as excellent shape-fixity properties compared to linear PU and non-ionic crosslinked PU. The non-ionic crosslinker resulted in hard and soft phases intermixing, whereas the ionic interaction in ionic liquid crosslinked PU kept the phase separation intact.
Preparation of multifunctional hollow microporous organic nanospheres via a one-pot hyper-cross-linking mediated self-assembly strategy
Authors: Xu Yang , Wang Tianqi , He Zidong , Zhou Minghong , Yu Wei , Shi Buyin , Huang Kun
Published: June 2018

Multifunctional hollow microporous organic nanospheres (HMONs) were successfully synthesized via a one-pot hyper-cross-linking mediated self-assembly strategy.
Design and preparation of quasi-spherical salt particles as water-soluble porogens to fabricate hydrophobic porous scaffolds for tissue engineering and tissue regeneration
Authors: Liang Xiangyu , Qi Yongli , Pan Zhen , He Yao , Liu Xiangnan , Cui Shuquan , Ding Jiandong
Published: June 2018

A novel quasi-spherical and water-soluble porogen was developed to fabricate porous scaffolds for tissue engineering and tissue regeneration.
In silicofunctional and tumor suppressor role of hypothetical protein PCNXL2 with regulation of the Notch signaling pathway
Authors: Naveed Muhammad , Imran Komal , Mushtaq Ayesha , Mumtaz Abdul Samad , Janjua Hussnain A. , Khalid Nauman
Published: June 2018

Since the last decade, various genome sequencing projects have led to the accumulation of an enormous set of genomic data; however, numerous protein-coding genes still need to be functionally characterized.
New synthetic pathway leading to oxospirochlorins
Authors: Śniechowska Justyna , Paluch Piotr , Pawlak Tomasz , Bujacz Grzegorz D. , Danikiewicz Witold , Potrzebowski Marek J.
Published: June 2018

Oxospirochlorins – novel analogs of porphyrinoids were synthesized and characterized by various methods including X-ray, NMR spectroscopy and mass spectrometry.
Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin in vivo
Authors: Hu Junshan , Zhan Shiping , Wu Xiaofeng , Hu Shigang , Wu Shaobing , Liu Yunxin
Published: June 2018

Doxorubicin (Dox) is a chemotherapy medication used to treat cancer.
Iron-doped ZnO as a support for Pt-based catalysts to improve activity and stability: enhancement of metal–support interaction by the doping effect
Authors: Trung Tran Si Bui , Choi Han Seul , Oh Sun Young , Moon Song Yi , Park Jeong Young
Published: June 2018

We deposited Pt nanoparticles on a series of Fe-doped ZnO with different Fe loadings to study the effect of dopant on the catalytic performance for the CO oxidation reaction.
Polariton chemistry: controlling molecular dynamics with optical cavities
Authors: Ribeiro Raphael F. , Martínez-Martínez Luis A. , Du Matthew , Campos-Gonzalez-Angulo Jorge , Yuen-Zhou Joel
Published: June 2018

Strong coupling of molecules with confined electromagnetic fields provides novel strategies to control chemical reactivity and spectroscopy.
Synthesis of a 2D phosphorus material in a MOF-based 2D nano-reactor
Authors: Li Ming , Ma Chuang , Liu Xiong , Su Jun , Cui Xiaofeng , He Yunbin
Published: June 2018

A 2D nano-reactor was constructed within a pillar–layer-MOF, in which a moderately stable 2D phosphorus material was synthesized.
A chemically induced proximity system engineered from the plant auxin signaling pathway
Authors: Zhao Weiye , Nguyen Huong , Zeng Guihua , Gao Dan , Yan Hao , Liang Fu-Sen
Published: June 2018

A new chemically induced proximity system is developed by engineering the plant auxin signaling pathway.
A 3D petal-like Ni3S2/CoNi2S4 hybrid grown on Ni foam as a binder-free electrode for energy storage
Authors: Chen Fangshuai , Wang Hui , Ji Shan , Linkov Vladimir , Wang Rongfang
Published: June 2018

A 3D petal-like Ni3S2/CoNi2S4 hybrid directly grown on Ni foam as a binder-free electrode is synthesized via a single step solvothermal method.
Adhesion of emulsified oil droplets to hydrophilic and hydrophobic surfaces – effect of surfactant charge, surfactant concentration and ionic strength
Authors: Dickhout Janneke M. , Kleijn J. Mieke , Lammertink Rob G. H. , de Vos Wiebe M.
Published: June 2018

Using a novel flow cell technique to study the adhesion of oil droplets to a surface under shear flow.
Rupture of granular rafts: effects of particle mobility and polydispersity
Authors: Planchette Carole , Lorenceau Elise , Biance Anne-Laure
Published: June 2018

The rupturing threshold of granular armor subjected to drop impacts for MOBILE (circles) and IMMOBILE (squares) particles.
Photocatalytic and electrically conductive transparent Cl-doped ZnO thin films via aerosol-assisted chemical vapour deposition
Authors: Jiamprasertboon Arreerat , Powell Michael J. , Dixon Sebastian C. , Quesada-Cabrera Raul , Alotaibi Abdullah M. , Lu Yao , Zhuang Aoyun , Sathasivam Sanjayan , Siritanon Theeranun , Parkin Ivan P. , Carmalt Claire J.
Published: June 2018

Cl-doped ZnO films, grown via aerosol-assisted CVD, can function as both TCOs and photocatalysts.
A fluorine-modulated bulk-phase heterojunction and tolerance factor for enhanced performance and structure stability of cesium lead halide perovskite solar cells
Authors: Fu Lin , Zhang Yanan , Chang Bohong , Li Bo , Zhou Shujie , Zhang Luyuan , Yin Longwei
Published: June 2018

The α-/δ-phase heterojunction induced by fluorine builds a matched band structure, exhibiting a champion PCE of 10.26% with improved stability.
Facile synthesis of NiS2nanoparticles ingrained in a sulfur-doped carbon nitride framework with enhanced visible light photocatalytic activity: two functional roles of thiourea
Authors: Jourshabani Milad , Shariatinia Zahra , Achari Gopal , Langford Cooper H. , Badiei Alireza
Published: June 2018

A one-step, simple and low-cost strategy was successfully used to produce novel NiS2/S-doped g-C3N4photocatalysts.
A two-dimensional cationic covalent organic framework membrane for selective molecular sieving
Authors: Zhang Wenxiang , Zhang Liming , Zhao Haifeng , Li Bin , Ma Heping
Published: June 2018

A two-dimensional cationic covalent organic framework membrane with extraordinary separation properties and high permeability.
Poly(arylene ether)s based on platinum(ii) acetylide complexes: synthesis and photophysical and nonlinear absorption properties
Authors: Du Yinlong , Dong Ningning , Zhang Menghan , Jiang Botao , Sun Ningwei , Luo Yuchao , Zhang Shuling , Wang Guibin , Wang Jun
Published: June 2018

Poly(arylene ether)s based on Pt(ii) acetylide and solid-state bulky materials with trade-offs between strong RSA and good transparency were reported.
Charge transfer doping in functionalized silicon nanosheets/P3HT hybrid material for applications in electrolyte-gated field-effect transistors
Authors: Lyuleeva Alina , Holzmüller Philipp , Helbich Tobias , Stutzmann Martin , Brandt Martin S. , Becherer Markus , Lugli Paolo , Rieger Bernhard
Published: June 2018

This work introduces microwave-assisted thermal hydrosilylation reaction for the functionalization of silicon nanosheets, leading to the successful electronic interaction within SiNS–substrate/P3HT-based hybrid blends.
miR-34 inhibits growth and promotes apoptosis of osteosarcoma in nude mice through targetly regulating TGIF2 expression
Authors: Xi Liang , Zhang Yongfeng , Kong Shengnan , Liang Wei
Published: June 2018

miR-34 was reported to be involved in multiple tumors occurrence and development. The aim of the present study was to explore the impact of miR-34 on osteosarcoma and related mechanisms. Tumor tissues and non-tumor tissues of 34 patients with osteosarcoma were collected. qRT-PCR detection revealed that miR-34 was significantly down-regulated in tumor tissues (P<0.05). hFOB 1.19 and MG-63 cells were cultured. qRT-PCR detection showed that miR-34 was also significantly down-regulated in MG-63 cells (P<0.05). After transfection by miR-34 mimics, MG-63 cells proliferation in nude mice was significantly impaired (P<0.05), and percentage of apoptosis as well as caspase-3 positive cells proportion of osteosarcoma tissue in nude mice was markly increased (P<0.05). Western blot and immunofluorescence results also demonstrated that TGIF2 relative expression and TGIF2 positive cells proportion were both dramatically decreased (P<0.05). By luciferase reporter assay, we found that TGIF2 was the target gene of miR-34. After transfected by TGIF2 overexpression vector or co-transfected by miR-34 mimics and TGIF2 overexpression vector, we observed that, compared with blank group, tumor volume was significantly increased and apoptotic cells as well as caspase-3 positive cells proportion was obviously decreased in TGIF2 group (P<0.05), while no significant difference was found in these indicators between blank group and TGIF2 + mimics group. We concluded that miR-34 inhibited growth and promoted apoptosis of osteosarcoma in nude mice through targetting regulated TGIF2 expression.