bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Reactions of 3‐Acetyl‐ and 3‐Acetimidoyl‐5,6,7,8‐tetrafluoro‐4‐hydroxycoumarins with Substituted Hydrazines.
Authors: Shcherbakov K. V. , Burgart Ya. V. , Saloutin V. I.
Published: September 2010

The title coumarins (I) react with phenyl‐ and methylhydrazine to give either condensation products of the acyl substituent [cf.
ChemInform Abstract: Synthesis, Anticancer and Antioxidant Activities of 7‐Methoxyisoflavanone and 2,3‐Diarylchromanones.
Authors: Kanagalakshmi Kanagasabai , Premanathan Mariappan , Priyanka Ragunathan , Hemalatha Balasubramanian , Vanangamudi Arumugasamy
Published: September 2010

This fast and high yielding method provides the diarylchromanones (III) and methoxyisoflavanone (V) by microwave‐assisted condensation.
ChemInform Abstract: Synthesis and Evaluation of Novel Chromone Analogues for Their Inhibitory Activity Against Interleukin‐5.
Authors: Thanigaimalai Pillaiyar , Hoang Tuan Anh Le , Lee Ki‐Cheul , Sharma Vinay K. , Bang Seong‐Cheol , Yun Jun Ho , Roh Eunmiri , Kim Youngsoo , Jung Sang‐Hun
Published: September 2010

The role of the B‐ring of isoflavone analogues for the inhibition of IL‐5 is investigated.
ChemInform Abstract: 2‐Pyridyl and 3‐Pyridylzinc Bromides: Direct Preparation and Coupling Reaction.
Authors: Kim Seung‐Hoi , Rieke Reuben D.
Published: September 2010

2‐Pyridyl and 3‐pyridylzinc bromides are readily prepared from the corresponding pyridylbromides and Rieke zinc.
ChemInform Abstract: Sodium Silicate‐Catalyzed Multicomponent Synthesis of Pyridine Dicarbonitriles.
Authors: Heravi Majid M. , Khorshidi Maliheh , Beheshtia Yahia. Sh. , Baghernejad Bita
Published: September 2010

Advantages of the title multicomponent synthesis are low cost, operational simplicity and minimal environmental impact.
ChemInform Abstract: Carbonic Anhydrase Inhibitors: Synthesis and Inhibition of the Human Cytosolic Isozymes I and II and Transmembrane Isozymes IX, XII (Cancer‐Associated) and XIV with 4‐Substituted 3‐Pyridinesulfonamides.
Authors: Brzozowski Zdzislaw , Slawinski Jaroslaw , Saczewski Franciszek , Innocenti Alessio , Supuran Claudiu T.
Published: September 2010

The pyridine‐derived sulfonamides (amines, ethers, hydrazines and sulfides) are investigated as inhibitors of five isoforms of zinc enzyme carbonic anhydrase.
ChemInform Abstract: Biomimetic Construction of the Hydroquinoline Ring System. Diastereodivergent Enantioselective Synthesis of 2,5‐Disubstituted cis‐Decahydroquinolines.
Authors: Amat Mercedes , Fabregat Robert , Griera Rosa , Florindo Pedro , Molins Elies , Bosch Joan
Published: September 2010

Straightforward, diastereodivergent approaches to 2,5‐disubstituted cis‐decahydroquinolines are developed which allow the synthesis of the alkaloid pumiliotoxin C (VIII) and diastereomers [cf.
ChemInform Abstract: Cyclofunctionalization of 6‐Alkenylsulfanylpyrazolo[3,4‐d]pyrimidin‐4(5H)‐ones with Arenesulfenyl Chlorides.
Authors: Vas'kevich A. I. , Bentya A. V. , Staninets V. I.
Published: September 2010

Reactions of the title alkenyl thioethers with arenesulfenyl chlorides in CHCl3 affords products of addition at the exocyclic double bond, while analogous reactions in acetic acid in the presence of LiClO4 are accompanied by an intramolecular electrophilic cyclization involving the N7 atom.
ChemInform Abstract: Synthesis of (3S)‐2,5‐Diethoxy‐3,6‐dihydro‐3‐isopropyl‐6‐methylsulfanylpyrazines and Stereoselectivity in Alkylation of the Anions.
Authors: Usami Yoshihide , Arimoto Masao , Kioka Chisaka , Yamanaka Masako , Matsuda Naoko , Ishikawa Hayato
Published: September 2010

The diastereomers of the title compound [cf.
ChemInform Abstract: Rearrangement in the Series of 3‐(2‐Aryl‐2‐oxoethyl)‐3,4‐dihydroquinoxalin‐2(1H)‐ones.
Authors: Kolos N. N. , Kovalenko L. Yu. , Kulikov A. Yu.
Published: September 2010

Heating the title quinoxalinones such as (I) and (III) with sulfur in DMF results in a rearrangement accompanied by elimination of the acyl groups.
ChemInform Abstract: Naftifine‐Analogues as anti‐Trypanosoma cruzi Agents.
Authors: Gerpe Alejandra , Boiani Lucia , Hernandez Paola , Sortino Maximiliano , Zacchino Susana , Gonzalez Mercedes , Cerecetto Hugo
Published: September 2010

The naftifine analogues are designed as potential T.cruzi membrane sterol biosynthesis inhibitors.
ChemInform Abstract: Synthesis, Spectral Characterization, and Biological Activity of Some New Substituted 10H‐Phenothiazines, Its Ribofuranosides, and Sulfones.
Authors: Gautam Naveen , Ajmera Neha , Gupta Shikha , Gautam D. C.
Published: September 2010

The title compounds (IIa), (IIIa), (Va), and (VIII) exhibit strong radical scavenging activity in the DPPH assay.
ChemInform Abstract: Pyrazole‐3(5)‐diazonium Salts in the Synthesis of Novel Pyrazolo[5,1‐c][1,2,4]triazines.
Authors: Shikhaliev Kh. S. , Didenko V. V. , Voronkova V. A. , Kryl'skii D. V.
Published: September 2010

Coupling of pyrazole‐3(5)‐diazonium salts with cyclic 1,3‐dicarbonyl compounds followed by cyclocondensation of the resulting hetarylhydrazones provides a facile access to novel pyrazolotriazine derivatives.
ChemInform Abstract: Regioselective Synthesis of 3‐Benzazepinones and Unexpected 5‐Bromo‐3‐benzazepinones.
Authors: Zhang Lei , Ye Deju , Zhou Yu , Liu Guannan , Feng Enguang , Jiang Hualiang , Liu Hong
Published: September 2010

Treatment of phenylacetamides of type (I) with AuCl(PPh3)/AgSbF6 allows simple access to 3‐benzazepinones.
ChemInform Abstract: Synthesis of (7S)‐(‐)‐7‐Aryl‐5‐methyl‐7‐trifluoromethyl‐1,3,6,7‐tetrahydro‐2H‐1,4‐dia zepin‐2‐ones (VII)
Authors: Vovk M. V. , Golovach N. M. , Sukach V. A. , Chernyuk O. N. , Manoilenko O. V.
Published: September 2010

from preparatively accessible β‐trifluoromethyl‐β‐amino ketones (I)
ChemInform Abstract: Stereospecific Coupling of H‐Phosphinates and Secondary Phosphine Oxides with Amines and Alcohols: A General Method for the Preparation of Optically Active Organophosphorus Acid Derivatives.
Authors: Wang Gang , Shen Ruwei , Xu Qing , Goto Midori , Zhao Yufen , Han Li‐Biao
Published: September 2010

The reaction with thiophenol (Vd) proceeds also successfully.
ChemInform Abstract: A New Diterpenoid Glucoside from Pteris semipinnata.
Authors: Shi Lin‐Mei , Bai Hai‐Bo
Published: September 2010

Chemical investigation of the aerial parts of Pteris semipinnata affords a new ent‐kaurane diterpenoid glucoside named pteriside (I) along with three known sesquiterpenoids.
ChemInform Abstract: Terpenoids Produced by Actinomycetes: Isolation, Structural Elucidation and Biosynthesis of New Diterpenes, Gifhornenolones A and B from Verrucosispora gifhornensis YM28‐088.
Authors: Shirai Masato , Okuda Masaaki , Motohashi Keiichiro , Imoto Masaya , Furihata Kazuo , Matsuo Yoshihide , Katsuta Atsuko , Shizuri Yoshikazu , Seto Haruo
Published: September 2010

Labeling experiments confirm that the MEP (2‐C‐methyl‐D‐erythritol‐4‐phosphate) pathway is used for the biosynthesis of gifhornenolone A (I) and B (II) in the title microorganism.
ChemInform Abstract: Two Novel Sesquiterpenoids from the Roots of Ferula ferulaeoides (Steud.) Korov.
Authors: Hu Yue , Li Xiao‐Dong , Li Guo‐Yu , Li Ning , Zuo Wen‐Jian , Zeng Yi‐Mei , Meng He , Li Xian , Wang Jin‐Hui
Published: September 2010

isolation and structure elucidation of ferulactones A (I) and B (II)
ChemInform Abstract: NW‐G01, a Novel Cyclic Hexapeptide Antibiotic, Produced by Streptomyces alboflavus 313. Part 2. Structural Elucidation.
Authors: Guo Zhengyan , Ji Zhiqin , Zhang Jiwen , Deng Jing , Shen Ling , Liu Wei , Wu Wenjun
Published: September 2010

NW‐G01 (I) is isolated as new antibiotic from the fermentation broth of Streptomyces alboflavus.
ChemInform Abstract: Synthesis and Properties of Fused Tetracyclic Derivatives of 1,4‐Naphthoquinone Thioglycosides.
Authors: Polonik S. G. , Denisenko V. A.
Published: September 2010

A series of 1,4‐naphthoquinone O‐acetylthioglycosides is synthesized by condensation of corresponding fully O‐acetylated 1‐mercaptosugars with naphthoquinone (II).
ChemInform Abstract: New Pentacyclic Cucurbitane Glucosides from the Fruits of Citrullus colocynthis Schrad
Authors: Nayab Durey , Perveen Shagufta , Ahmed Zaheer , Malik Abdul
Published: September 2010

isolation of structure elucidation of colocynthins A‐D
ChemInform Abstract: Four New Nor‐Diterpenoid Alkaloids from Aconitum brachypodum
Authors: Shen Yong , Zuo Ai‐Xue , Jiang Zhi‐Yong , Zhang Xue‐Mei , Wang Hong‐Ling , Chen Ji‐Jun
Published: September 2010

isolation and structure elucidation of brachyaconitines A‐D
ChemInform Abstract: An Efficient Deprotection of N‐Trimethylsilylethoxymethyl (SEM) Groups from Dinucleosides and Dinucleotides.
Authors: Chandra Tilak , Broderick William E. , Broderick Joan B.
Published: September 2010

An efficient method for the deprotection of N‐trimethylsilylethoxymethyl (SEM) groups from dinucleosides and dinucleotides of type (I) or (III) is presented.
ChemInform Abstract: Solid‐Phase Synthesis of Oligodeoxyribonucleotides Without Base Protection Utilizing O‐Selective Reaction of Oxazaphospholidine Derivatives.
Authors: Oka Natsuhisa , Maizuru Yukihiro , Shimizu Mamoru , Wada Takeshi
Published: September 2010

Chlorooxazaphospholidine (II) exclusively reacts with the 3‐OH group of nucleosides (III) in the presence of unprotected nucleobase amino groups to afford the nucleoside O‐oxazaphospholidine monomers (IV) in moderate to good yields.
ChemInform Abstract: An Improved One‐Pot Synthesis of Nucleoside 5′‐Triphosphate Analogues.
Authors: Gillerman Irina , Fischer Bilha
Published: September 2010

The one‐pot conversion of nucleosides (I) to the 5′‐triphosphate analogues (II) proceeds under conditions inhibiting the formation of several by‐products, which not only reduce the yield but make the ion‐exchange LC purification of the final product almost impossible.
ChemInform Abstract: A New Coumarin and Carbazole Alkaloid from Clausena vestita D. D. Tao.
Authors: Shi Xiao‐Jing , Ye Guan , Tang Wen‐Jie , Zhao Wei‐Min
Published: September 2010

isolation and structure elucidation of clauslactone U (I) and clauszoline N (II)
ChemInform Abstract: Antimycin A18 Produced by an Endophytic Streptomyces albidoflavus Isolated from a Mangrove Plant.
Authors: Sun Cheng‐Hang , et al. et al.
Published: September 2010

Title compound (I) is described as the first naturally occurring antimycin with an 8‐O‐acetyl side chain.
ChemInform Abstract: JBIR‐58, a New Salicylamide Derivative, Isolated from a Marine Sponge‐Derived Streptomyces sp. SpD081030ME‐02.
Authors: Ueda Jun‐ya , Khan Shams Tabrez , Takagi Motoki , Shin‐ya Kazuo
Published: September 2010

This is the first report of a pyranoisochromone derivative isolated from Streptomyces.
ChemInform Abstract: An Efficient Improvement on Total Synthesis of Shikonin.
Authors: Rao Zhen , Zhou Wen , Peng Ying , Li Shao‐Shun
Published: September 2010

The problem associated with electrolytic deprotection, which is a concern in the total synthesis of shikonin (II), is solved by addition of Cu2+.
ChemInform Abstract: Dramatic Improvement of Excitonic Photoluminescence in Metal Halide Films
Authors: Kondo S. , Saito T.
Published: September 2010

Review: 105 refs.
ChemInform Abstract: On the Peroxomolybdate Complexes as Sources of Singlet Oxygen
Authors: Csanyi Laszlo J.
Published: September 2010

Review: 40 refs.
ChemInform Abstract: Solvothermal Synthesis and Structure of Chalcogenidoarsenate Anions
Authors: Kromm Anna , van Almsick Tobias , Sheldrick William S.
Published: September 2010

Review: 123 refs.
ChemInform Abstract: Synthesis of Inorganic—Organic Hybrid Thiometallate Materials with a Special Focus on Thioantimonates and Thiostannates and in situ X‐Ray Scattering Studies on Their Formation
Authors: Seidlhofer Beatrix , Pienack Nicole , Bensch Wolfgang
Published: September 2010

Review: 179 refs.
ChemInform Abstract: Chelates of Fluoroalkyl‐Containing Enaminoketones
Authors: Filyakova V. I. , Chizhov D. L. , Khmara E. F. , Charushin V. N.
Published: September 2010

Review: 77 refs.
ChemInform Abstract: Tuning Structures and Properties of Coordination Polymers by the Noncoordinating Backbone of Bridging Ligands
Authors: Du Miao , Bu Xian‐He
Published: September 2010

Review: 157 refs.
ChemInform Abstract: Indium(III)‐Organic Coordination Polymers with Versatile Topological Structures Based on Multicarboxylate Ligands
Authors: Chen Lian , Jiang Fei‐Long , Lin Zheng‐Zhong , Hong Mao‐Chun
Published: September 2010

Review: 76 refs.
ChemInform Abstract: Coordinative Flexibility of Monovalent Silver in AgI Complexes
Authors: Meyer Gerd , Sehabi Muhamet , Pantenburg Ingo
Published: September 2010

Review: 41 refs.
ChemInform Abstract: Oxo‐Centered Triruthenium‐acetate Cluster Complexes Derived from Axial or Bridging Ligand Substitution
Authors: Chen Zhong‐Ning , Dai Feng‐Rong
Published: September 2010

Review: 31 refs.
ChemInform Abstract: N,S‐Heterocyclic Carbene Complexes
Authors: Chien Sheau W. , Yen Swee K. , Hor T. S. Andy
Published: September 2010

Review: No Abstract
ChemInform Abstract: The Development and Pharmacology of Proteasome Inhibitors for the Management and Treatment of Cancer
Authors: Ruggeri Bruce , Miknyoczki Sheila , Dorsey Bruce , Hui Ai‐Min
Published: September 2010

Review: 155 refs.
ChemInform Abstract: Reactions of Metal‐Promoted C—C coupling of Coordinated 1,10‐Phenanthrolines in the Synthesis of Electron‐Rich D‐Element 1,10‐Phenanthrocyanines
Authors: Demidov V. N. , Simanova S. A. , Savinov A. I. , Pakhomov T. B.
Published: September 2010

Review: 65 refs.
ChemInform Abstract: Advances in Microwave‐Assisted Synthesis of Ordered Mesoporous Materials
Authors: Cao Yuan , Wei Hong‐juan , Xia Zhi‐ning
Published: September 2010

Review: 45 refs.
ChemInform Abstract: 1,3‐ and 1,2‐Unsaturated Butadiene Derivatives as Valuable Synthetic Tools in Organometallic Syntheses
Authors: Deagostino Annamaria , Prandi Cristina , Tabasso Silvia , Venturello Paolo
Published: September 2010

Review: 95 refs.
ChemInform Abstract: Recent Advances in Activation of Silicon Bonds by Fluoride Ion
Authors: Abele Edgars , Abele Ramona
Published: September 2010

Review: 145 refs.
ChemInform Abstract: The Present Stage of Development of the Chemistry of Phosphorus‐Containing Anthracene Derivatives
Authors: Slitikov P. V. , Petrov A. V. , Rasadkina E. N. , Nifant'ev E. E.
Published: September 2010

Review: 102 refs.
ChemInform Abstract: TiO2 in Organic Photosynthesis: Sunlight‐Induced Functionalization of Heterocyclic Bases
Authors: Gambarotti Cristian , Punta Carlo , Recupero Francesco , Caronna Tullio , Palmisano Leonardo
Published: September 2010

Review: 79 refs.
ChemInform Abstract: Tetradehydrodinaphtho[10]annulene and Its Transformation into Zethrene: A Hitherto Unknown Dehydroannulene and a Forgotten Aromatic Hydrocarbon
Authors: Umeda Rui , Hibi Daijiro , Miki Koji , Tobe Yoshito
Published: September 2010

Review: 47 refs.
ChemInform Abstract: Regioselective Catalytic Activity of Complexes with NH, NS‐Substituted Heterocyclic Carbene Ligands
Authors: Waldvogel Siegfried R. , Spurg Anke , Hahn F. Ekkehardt
Published: September 2010

Review: 105 refs.
ChemInform Abstract: The Pauson—Khand Reaction in the Synthesis of Pharmacologically Active Compounds
Authors: Habermann Jorg
Published: September 2010

Review: 50 refs.
ChemInform Abstract: Recent Uses of Iron Catalysts in Organic Reactions
Authors: Liu Liang‐Xian
Published: September 2010

Review: 221 refs.
ChemInform Abstract: Recent Advances in Multicomponent Reactions for Diversity‐Oriented Synthesis
Authors: Biggs‐Houck James E. , Younai Ashkaan , Shaw Jared T.
Published: September 2010

Review: 86 refs.
ChemInform Abstract: Cleome viscosa (Wild Mustard): Ethnobotany, Phytochemistry, and Pharmacology
Authors: Mali Ravindra G.
Published: September 2010

Review: 61 refs.
ChemInform Abstract: Naturally Occurring Nitrogen—Sulfur Compounds. Part 2. 1,4‐Thiazine and Benzo‐1,4‐thiazine Alkaloids.
Authors: Lucas Catherine L. , Moody Christopher J.
Published: September 2010

Review: ca. 80 refs.
ChemInform Abstract: A Novel Antidepressant‐Like Action of Drugs Possessing GIRK Channel Blocking Action in Rats
Authors: Kawaura Kazuaki , Honda Sokichi , Soeda Fumio , Shirasaki Tetsuya , Takahama Kazuo
Published: September 2010

Review: 46 refs.
ChemInform Abstract: A New Perspective on the Use of Plant Secondary Metabolites to Inhibit Methanogenesis in the Rumen
Authors: Patra Amlan K. , Saxena Jyotisna
Published: September 2010

Review: ca. 160 refs.
ChemInform Abstract: Surface X‐Ray Studies of Catalytic Clean Technologies
Authors: Lee Adam F. , Prabhakaran Vinod , Wilson Karen
Published: September 2010

Review: 181 refs.
ChemInform Abstract: Collaborative Use of Neutron and X‐Ray for Determination of Drug Target Proteins
Authors: Kuroki Ryota , Tamada Taro , Kurihara Kazuo , Ohhara Takashi , Adachi Motoyasu
Published: September 2010

Review: 16 refs.
Vasopressin (VP) and neuropeptide FF (NPFF) systems in the normal and hypertensive human brainstem
Authors: Goncharuk Valeri D. , Buijs Ruud M. , Jhamandas Jack H. , Swaab Dick F.
Published: September 2010

Vasopressin (VP)‐, neuropeptide FF (NPFF)‐, and tyrosine hydroxylase (TH)‐expressing neurons were studied by means of single and double immunocytochemistry in the human brainstem of controls who died suddenly due to trauma and of patients who suffered from essential hypertension and died due to acute myocardial infarction, while in one case there was brain hemorrhage. In the control and hypertensive groups VP fibers and NPFF neurons and fibers were the most abundantly present in the dorsal vagal complex, especially in the dorsal motor nucleus of the vagus. Numerous VP and NPFF fibers formed synaptic‐like contacts with neuronal profiles in the dorsointermediate, centrointermediate, ventrointermediate, caudointermediate, and caudal parts of the dorsal motor nucleus of vagus as well as adjacent medial and intermediate subnuclei of the solitary nucleus. VP, but not NPFF, positive fibers were found to vastly contact TH‐positive neuronal profiles in A2/C2, A2, and ambiguus nucleus (Amb). The density of VP fibers in the dorsal motor nucleus of the vagus and Amb did not differ between hypertensive patients and controls, whereas the density of NPFF fibers in hypertensives was 3.19 times lower in the dorsal motor nucleus of vagus and markedly decreased in the Amb. In both groups, VP and NPFF were scarcely present in the pain pathways, suggesting that these peptides are not crucially involved in nociceptive control in human. The reduction of NPFF release within the dorsal motor nucleus and Amb could serve as a possible cause of the impairment of cardiac vagal control in hypertensive patients. J. Comp. Neurol. 519:93‐124, 2011. © 2010 Wiley‐Liss, Inc.
Meis gene expression patterns in the developing chicken inner ear
Authors: Sánchez‐Guardado Luis Óscar , Ferran José Luis , Rodríguez‐Gallardo Lucía , Puelles Luis , Hidalgo‐Sánchez Matías
Published: September 2010

We are interested in stable gene network activities operating sequentially during inner ear specification. The implementation of this patterning process is a key event in the generation of functional subdivisions of the otic vesicle during early embryonic development. The vertebrate inner ear is a complex sensory structure that is a good model system for characterization of developmental mechanisms controlling patterning and specification. Meis genes, belonging to the TALE family, encode homodomain‐containing transcription factors remarkably conserved during evolution, which play a role in normal and neoplastic development. To gain understanding of the possible role of homeobox Meis genes in the developing chick inner ear, we comprehensively analyzed their spatiotemporal expression patterns from early otic specification stages onwards. In the invaginating otic placode, Meis1/2 transcripts were observed in the borders of the otic cup, being absent in the portion of otic epithelium closest to the hindbrain. As development proceeds, Meis1 and Meis2 expressions became restricted to the dorsomedial otic epithelium. Both genes were strongly expressed in the entire presumptive domain of the semicircular canals, and more weakly in all associated cristae. The endolymphatic apparatus was labeled in part by Meis1/2. Meis1 was also expressed in the lateral wall of the growing cochlear duct, while Meis2 expression was detected in a few cells of the developing acoustic‐vestibular ganglion. Our results suggest a possible role of Meis assigning regional identity in the morphogenesis, patterning, and specification of the developing inner ear. J. Comp. Neurol. 519:125‐147, 2011. © 2010 Wiley‐Liss, Inc.
Organization and development of zebra finch HVC and paraHVC based on expression of zRalDH, an enzyme associated with retinoic acid production
Authors: Olson Christopher R. , Rodrigues Paulo Vianney , Jeong Jin Kwon , Prahl Daniel J. , Mello Claudio V.
Published: September 2010

The zRalDH gene encodes an aldehyde dehydrogenase associated with the conversion of retinaldehyde (the main vitamin A metabolite) into retinoic acid and its expression is highly enriched in the song control system of adult zebra finches (Taeniopygia guttata). Within song control nucleus HVC, zRalDH is specifically expressed in the neurons that project to area X of the striatum. It is also expressed in paraHVC, commonly considered a medial extension of HVC that is closely associated with auditory areas in the caudomedial telencephalon. Here we used in situ hybridization to generate a detailed analysis of HVC and paraHVC based on expression of zRalDH for adult zebra finches of both sexes and for males during the song‐learning period. We demonstrate that the distribution of zRalDH‐positive cells can be used for accurate assessments of HVC and paraHVC in adult and juvenile males. We describe marked developmental changes in the numbers of zRalDH‐expressing cells in HVC and paraHVC, reaching a peak at day 50 posthatch, an effect potentially due to dynamic changes in the population of X‐projecting cells in HVC. We also show that zRalDH‐expressing cells in adult females, although much less numerous than in males, have a surprisingly broad distribution along the medial‐to‐lateral extent of HVC, but are lacking where paraHVC is found in adult males. Our study thus contributes to our understanding of the nuclear organization of the song system and the dynamics of its developmental changes during the song‐learning period. J. Comp. Neurol. 519:148‐161, 2011. © 2010 Wiley‐Liss, Inc.
Generation of mice with a conditional and reporter allele for Tmem100
Authors: Moon Eun‐Hye , Kim Mi‐Jung , Ko Keum Soun , Kim Yoo Sung , Seo Jiyoung , Oh S. Paul , Lee Young Jae
Published: September 2010

Activin receptor‐like kinase 1 (ACVRL1; ALK1) is predominantly expressed in arterial endothelial cells and plays an important role in angiogenesis. ACVRL1 mutations cause hereditary hemorrhagic telangiectasia (HHT), a genetic vascular disorder for which the underlying mechanism is poorly understood. We have found that expression of transmembrane protein 100 (Tmem100) is downregulated in the lung of Acvrl1‐deficient mice; however, its function is unknown. To elucidate the role of Tmem100 in vivo, we generated a conditional knockout allele for Tmem100 in which exon3, containing the entire coding sequence, was flanked by loxP sequences. The targeted allele also possessed a lacZ reporter cassette in intron2 for visualization of Tmem100 expression. We found that Tmem100 was predominantly expressed in arterial endothelial cells of developing embryos. The conditional and reporter allele will be a useful resource to investigate the in vivo role of Tmem100, especially in angiogenesis. genesis 48:673–378, 2010. © 2010 Wiley‐Liss, Inc.
Analysis of carotenoids and vitamin E in selected oilseeds, press cakes and oils
Authors: Franke Saskia , Fröhlich Kati , Werner Susanne , Böhm Volker , Schöne Friedrich
Published: September 2010

Carotenoids and vitamin E in oils from the market – 6 rapeseed and 6 sunflower oils, half of each cold pressed and refined – and in the oils of rape, sunflower, flax and safflower as well as the respective seeds and press cakes from a local oil mill were quantified by HPLC. Furthermore, a photometric determination of carotenoid content was tested and checked against the chromatographic method. In the cold pressed oils minor amounts of xanthophylls (all‐E)‐lutein and (all‐E)‐zeaxanthin were determined. With exception of traces of (all‐E)‐β‐carotene in cold‐pressed rapeseed oil this provitamin A active compound did not occur. Cold pressed rapeseed oils contained 0.5–1.5 mg total carotenoids/100 g which was manifold the content of the further oils. Vitamin E was found in all vegetable oils at plant‐typic tocopherol patterns. The photometric determination of carotenoids resulted in significantly higher concentrations compared to the HPLC. This overestimation bases on the carotenoid pattern which was validated by comparison with known high‐carotenoid materials, i.e. maize flour with an abundant amount of xanthophylls and carrots with an abundant amount of carotenes.
Synthesis and Characterization of Chromium Hexacyanoferrate/Multiwalled Carbon Nanotube Composite and Its Biosensing for L‐Cysteine
Authors: Shen Rongxing , Li Xiangzi , Lium Guilin , Ji Yulan , Wang Guangfeng , Fang Bin
Published: September 2010

This work describes the electrochemical properties of glassy carbon electrodes (GCE) modified with chromium(III) hexacyanoferrate(II) (Crhf) nanoparticles attached multiwalled carbon nanotube (MWNTs). The morphological characterization of Crhf/MWNTs nanocomposites was examined by scanning electron microscopy (SEM), UV‐vis spectroscopy, and Fourier transform infrared spectrometry (FT‐IR). The electrocatalytic activity of these nanocomposites was investigated and showed a good electrocatalytic effect for oxidation of L‐cysteine (L‐Cys) in 0.1 M phosphate buffer solution (pH 3.0). Under optimum conditions linear calibration graphs were obtained over the L‐Cys concentration range 5.0×10−7 to 6.0×10−5 M with a correlation coefficient of 0.9998 and a detection limit (signal‐to‐noise ratio was 3) of 1.0×10−8 M. The proposed method is simple and it also showed excellent sensitivity and stability. The excellent electrocatalytic ability of the modified electrode towards L‐Cys manifests that the Crhf/MWNTs can provide a new platform for biosensors and other biology.
Electrochemical Studies of the Neuraminidase Inhibitor Zanamivir and its Voltammetric Determination in Spiked Urine
Authors: Skrzypek S.
Published: September 2010

Zanamivir is a member of a new class of antiviral agents that selectively inhibit the enzyme neuraminidase of influenza A H5N1 and H1N1 viruses. Although zanamivir is the compound of biological interest, so far it has not been a subject of any electrochemical studies. It was stated, that zanamivir can act as an electrocatalyst at HMDE. The electrode mechanism is connected with the hydrogen evolution reaction catalyzed by zanamivir as the guanidine compound. A new adsorptive catalytic method for its voltammetric (SW AdSV) determination was developed. The dependence of the peak current on pH, buffer concentration, nature of the buffer and instrumental parameters were studied. The best results were received in citrate‐phosphate buffer at pH 2.2. This electroanalytical procedure enabled to determine zanamivir in the concentration range 4.8×10−7–1.2×10−5 mol L−1 in supporting electrolyte and diluted urine. Precision, repeatability and accuracy of the method were checked in both media. The detection and quantification limits were found to be 1.5×10−7 and 4.8×10−7 mol L−1 respectively. A standard addition method was used to determine zanamivir in spiked urine.
Gold Nanoparticle Modified Screen Printed Electrodes for the Trace Sensing of Arsenic(III) in the Presence of Copper(II)
Authors: Khairy Mohamed , Kampouris Dimitrios K. , Kadara Rashid O. , Banks Craig E.
Published: September 2010

Gold ensembles for the trace level sensing of arsenic(III) in the presence of copper(II) are reported. The gold ensembles are fabricated using citrate capped gold nanoparticles which are chemically synthesised in an aqueous solution with an aliquot of this simply cast onto an economical and disposable screen printed electrode. After drying at room temperature, the gold ensembles are ready for use. The gold ensembles are explored towards the sensing of arsenic(III) in the presence of copper(II) using anodic stripping voltammetry where the corresponding stripping peaks are well resolved and using this protocol it is possible to readily detect 3 µg L−1 (3 ppb) with a detection limit of 0.4 µg L−1 (0.4 ppb). Proof‐of‐concept is also shown for the sensing of arsenic(III) in a canal water sample. Given the low cost of the sensor and ease of fabrication, the gold ensembles hold promise for the sensing of arsenic(III) in water samples where copper(II) may be present.
Electrochemical Redox Behaviour of Temozolomide Using a Glassy Carbon Electrode
Authors: Ghalkhani Masoumeh , Fernandes Isabel P. G. , Oliveira S. Carlos B. , Shahrokhian Saeed , Oliveira‐Brett Ana Maria
Published: September 2010

The electrochemical behaviour of temozolomide on a glassy carbon electrode has been investigated. The reduction of temozolomide is an irreversible process, pH dependent, and the mechanism involves the addition of one electron and one proton to C5 to form an anion radical, causing the irreversible breakdown of the tetrazinone ring. The oxidation mechanism of temozolomide is an irreversible, adsorption‐controlled process, pH dependent up to value close to the pKa and occurs in two consecutive charge transfer reactions, with the formation of the hydroxylated product. The electroanalytical determination of TMZ led to a detection limit of 1.1 µM.
Electrocatalytic Oxidation of Diethylaminoethanethiol and Hydrazine at Single‐walled Carbon Nanotubes Modified with Prussian Blue Nanoparticles
Authors: Adekunle Abolanle S. , Ozoemena Kenneth I.
Published: September 2010

In this work, edged plane pyrolytic graphite electrode EPPGE was modified with functionalised single‐walled carbon nanotubes and Prussian blue nanoparticles (PB). The modified electrode was characterised by techniques such as TEM, FTIR, XPS, EDX and cyclic voltammetry. The EPPGE‐SWCNT‐PB platform exhibited enhanced electron transport and catalytic efficiency towards the oxidation of Diethylaminoethanethiol (DEAET) and hydrazine compared with the other electrodes studied. The EPPGE‐SWCNT‐PB showed good electrochemical stability in the analytical solution, showing limit of detection in the micromolar range and catalytic rate constant of 3.71×106 and 7.56×106 cm3 mol−1 s−1 for DEAET and hydrazine respectively. The adsorption properties of these analytes that impact on their detection at the SWCNT‐PB film modified electrode were evaluated and discussed.
Electrochemical Capacitive Behaviour of Multiwalled Carbon Nanotubes Modified with Electropolymeric Films of Nickel Tetraaminophthalocyanine
Authors: Chidembo Alfred T. , Ozoemena Kenneth I.
Published: September 2010

Electrochemical capacitive behaviour of the electropolymeric nickel tetra‐aminophthalocyanine (poly‐NiTAPc) supported on multiwalled carbon nanotube (MWCNT) platform is described. From the data in 1 M H2SO4, the MWCNT‐poly‐NiTAPc exhibited superior capacitance (112 mF cm−2 or 777 F g−1). The supercapacitance of the MWCNT‐polyNiTAPc was found to be much better in 1 M H2SO4 than in 1 M NaOH medium. Impedance data proved that most of the stored energy of the MWCNT‐poly‐NiTAPc could be accessible at high frequency (1.6 kHz). The electrode is capable of undergoing continuous charge‐discharge process for more than a 1000 cycles without any significant deterioration in the stability.
High‐Performance Amperometric Sensors Using Catalytic Platinum Nanoparticles‐Thionine‐Multiwalled Carbon Nanotubes Nanocomposite
Authors: Yu Rongmin , Wang Lihua , Xie Qingji , Yao Shouzhuo
Published: September 2010

Thionine (TH) adsorbed on multiwalled carbon nanotubes (MWCNTs) increases the load and dispersion of platinum nanoparticles (PtNPs) generated by chemical reduction of H2PtCl6 with NaBH4. Under the optimum conditions, the PtNPs‐TH‐MWCNTs/Au electrode electrocatalyzed the reduction and oxidation of H2O2 with high sensitivity, and after glucose oxidase (GOx) adsorption it responded to glucose concentration with a sensitivity of 0.14 A M−1 cm−2. The cyclic voltammetric cathodic peak current for NO2− reduction on PtNPs‐TH‐MWCNTs/Au responded linearly to NO2− concentration from 0.5 to 150 µM, with a sensitivity of 5.52 A M−1 cm−2 and a detection limit of 0.2 µM.
Comparative Studies on Electrocatalytic Activities of Chemically Reduced Graphene Oxide and Electrochemically Reduced Graphene Oxide Noncovalently Functionalized with Poly(methylene blue)
Authors: Liu Qing , Li Yang , Zhang Lanyong , Li Di , Fan Chunhai , Long Yi‐Tao
Published: September 2010

This study compares the electrocatalytic activities of chemically reduced graphene oxide (crGO) and electrochemically reduced graphene oxide (erGO), which are both noncovalently functionalized with a polyaromatic dye, poly(methylene blue) (polyMB), toward the oxidation of β‐nicotinamide adenine dinucleotide (NADH). PolyMB‐crGO and polyMB‐erGO composites were obtained via electropolymerization of methylene blue on crGO and GO modified glassy carbon (GC) electrodes, respectively. Cyclic voltammetry (CV) results indicate that these two types of integrated electrodes reveal different electrocatalytic activities. PolyMB‐crGO integrated electrode possesses lower catalytic oxidation potential, suggesting higher catalytic activity. The present study is helpful for the understanding and screening of graphene‐based advanced carbon nanomaterials for potential electrochemical applications.
Systems level engineering of Corynebacterium glutamicum – Reprogramming translational efficiency for superior production
Authors: Becker Judith , Buschke Nele , Bücker René , Wittmann Christoph
Published: September 2010

In this study, we replaced the natural start codons of different enzymes in the central carbon metabolism of Corynebacterium glutamicum to influence their activity toward improved production of the feed amino acid lysine. It was found that the translational start codon directly affects the intracellular activity of the encoded enzyme, whereby the common ATG generally led to higher values as compared with the rare variant GTG. This could be exploited to specifically amplify or attenuate enzyme activities in order to redirect carbon flux from undesired, competing pathways toward reactions supporting lysine formation. Replacement of the natural ATG codon by GTG reduced the specific enzyme activity of pyruvate dehydrogenase (PDH) and phosphoglucoisomerase by 60 and 40%, respectively. Vice versa, the activity of glucose 6‐phosphate dehydrogenase was increased by 40% by the substitution GTG‐>ATG. Implementation of the attenuated pyruvate dehydrogenase in the background of lysine producing C. glutamicum increased product yield by 17%. This was related to a redirection of the metabolic flux toward the supply of the lysine precursor oxaloacetate. The amplified expression of glucose 6‐phosphate dehydrogenase by the start codon exchange increased lysine yield by 10%, linked to an increased flux toward NADPH supply in the pentose phosphate pathway.
Enzyme‐aided wool dyeing with a neutral protease at reduced temperatures
Authors: Periolatto Monica , Ferrero Franco , Giansetti Mirco , Mossotti Raffaella , Innocenti Riccardo
Published: September 2010

Conventional wool dyeing methods are based on long times at high temperatures. These are energy intensive and can even damage the fibers, thus changing the desired fiber characteristics. In this work, enzyme pretreatment in combination with lower temperatures was used to reach exhaustion values comparable to those obtained with the standard procedure at 98°C. Kinetic runs carried out on wool yarn at different temperatures confirmed the possibility of obtaining more than 90% of bath exhaustion by dyeing at 85°C due to the pretreatment with a proteolytic enzyme. At the same temperature, without enzymatic pretreatment, just 77% of bath exhaustion can be reached. The enzyme action on the dyeing kinetics was investigated through calculation of dye absorption rate constants according to the diffusion‐limited kinetic model proposed by Chrastil. Dynamometric measurements on the yarn dyed at 98°C showed a 25% loss of tensile strength and 50% loss of elongation, while at lower temperature the values were better even after enzyme pretreatment, in agreement with the results of scanning electron microscopy analysis. A temperature of 85°C with enzyme pretreatment was found to be optimal taking into account satisfactory washing, perspiration and light fastness values.
Mitigation of Water Management in PEM Fuel Cell Cathodes by Hydrophilic Wicking Microporous Layers
Authors: Schweiss R. , Steeb M. , Wilde P. M.
Published: September 2010

This study introduces a novel strategy for enhancing the performance of polymer electrolyte fuel cells at high current densities by means of an advanced gas diffusion layer design. The incorporation of hydrophilic wicking agents into microporous layers of the cathode gas diffusion layer improves water management, thus increasing the maximum power density of polymer electrolyte fuel cells. Ex situ measurements with respect to water and vapour transport, and electrochemical polarisation data provide evidence suggesting that the beneficial effect has to be attributed to enhanced liquid water removal through the microporous layer.
New type of tetrazine‐substituted metallophthalocyanines by microwave irradiation: Synthesis and characterization
Authors: Saka Ece Tuǧba , Yıldırım Nuri , Kantekin Halit
Published: September 2010

5,6‐bis(4‐methylphenyl)‐2,3‐dihydro‐1,2,3,4‐tetrazine 2 was synthesized by the dimerization of ethyl p‐methylbenzoateformylhydrazone 1 in hydrazinehydrate solution. 2,3‐bis(4‐methylphenyl)‐6,7,14,15‐tetrahydro[1,2,3,4]tetrazino [2,3d][1,8, 4,5]benzodithia‐diazecine‐10,11‐dicarbonitrile 4 was sythesized by cyclization reaction of tetrazine monomer 2 onto 1,2‐bis‐(2‐iodoethylmercapto)‐4,5‐dicyanobenzene 3. Co(II) and Cu(II) phthalocyanine complexes were prepared by reaction of the dinitrile compound (4) with the chlorides of Co(II), Cu(II), and DMAE at 175°C, 350 W in a microwave oven for 10 min. Zn(II)‐phthalocyanine complex was prepared by reaction of the dinitrile compound 4 with the acetate of Zn(II) and DMAE at 175°C, 350 W in a microwave oven for 10 min. The new compounds were characterized by a combination of IR, 1H‐NMR, 13CNMR, UV‐vis, elemental analysis, and MS spectral data. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:456–461, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20623
The male–female gap in physician earnings: evidence from a public health insurance system
Authors: Theurl Engelbert , Winner Hannes
Published: September 2010

Empirical evidence from US studies suggests that female physicians earn less than their male counterparts, on average. The earnings gap does not disappear when individual and market characteristics are controlled for. This paper investigates whether a gender earnings difference can also be observed in a health‐care system predominantly financed by public insurance companies. Using a unique data set of physicians' earnings recorded by a public social security agency in an Austrian province between 2000 and 2004, we find a gender gap in average earnings of about 32%. A substantial share of this gap (20–47%) cannot be explained by individual and market characteristics, leaving labor market discrimination as one possible explanation for the observed gender earnings difference of physicians. Copyright © 2010 John Wiley & Sons, Ltd.
Extinction of spatial memory alters CREB phosphorylation in hippocampal CA1
Authors: Porte Y. , Trifilieff P. , Wolff M. , Micheau J. , Buhot M.C. , Mons N.
Published: September 2010

Although the importance of cAMP‐response element binding protein (CREB) phosphorylation in long‐term memory formation is well documented for hippocampus‐dependent tasks, little is known about the changes in phosphorylated CREB (pCREB) that occur during the process of extinction. The purpose of this study was to characterize the temporal patterns of pCREB in the CA1 and the amygdala after the extinction of previously acquired spatial information in the water maze. Mice were trained to find a hidden platform located at a fixed position and then were given extinction sessions in which the platform was either absent (NoPF) or relocated every day (RandomPF). We show that water maze spatial training evoked a biphasic response of pCREB in the CA1, with two different peaks occurring 15 min and 8 h postacquisition. The extinction of the original spatial preference significantly reduced the two peaks of CA1 pCREB in both RandomPF and NoPF groups whereas CA1 pCREB at 60 min post‐training remained unaffected. Moreover, the early and late phases of extinction training produced regionally dissociable effects on pCREB in the CA1 and the lateral nucleus of the amygdala. These findings provide new insights on the molecular dynamics and anatomical dissociations underlying spatial memory and extinction learning. © 2010 Wiley Periodicals, Inc.
GluK1 inhibits calcium dependent and independent transmitter release at associational/commissural synapses in area CA3 of the hippocampus
Authors: Salmen Benedikt , Beed Prateep S. , Özdogan Tugba , Maier Nikolaus , Johenning Friedrich W. , Winterer Jochen , Breustedt Jörg , Schmitz Dietmar
Published: September 2010

CA3 pyramidal cells receive three main excitatory inputs: the first one is the mossy fiber input, synapsing mainly on the proximal apical dendrites. Second, entorhinal cortex cells form excitatory connections with CA3 pyramidal cells via the perforant path in the stratum lacunosum moleculare. The third input involves the ipsi‐and contralateral connections, termed the associational/commissural (A/C) pathway terminating in the stratum radiatum of CA3, thus forming a feedback loop within this region. Since this excitatory recurrent synapse makes the CA3 region extremely prone to seizure development, understanding the regulation of synaptic strength of this connection is of crucial interest. Several studies suggest that kainate receptors (KAR) play a role in the regulation of synaptic strength. Our aim was to characterize the influence of KAR on A/C synaptic transmission: application of ATPA, a selective agonist of the GluK1 KAR, depressed the amplitude fEPSP without affecting the size of the fiber volley. Blockade of GABA receptors had no influence on this effect, arguing against the influence of interneuronal KARs. Pharmacological and genetic deletion studies could show that this effect was selectively due to GluK1 receptor activation. Several lines of evidence, such as PPF changes, coefficient of variance–analysis and glutamate uncaging experiments strongly argue for a presynaptic locus of suppression. This is accompanied by an ATPA‐mediated reduction in Ca2+ influx at excitatory synaptic terminals, which is most likely mediated by a G‐Protein dependent mechanism, as suggested by application of pertussis toxin. Finally, analysis of miniature EPSCs in the presence and absence of extracellular Ca2+ suggest that presynaptic KAR can also reduce transmitter release downstream and therefore independent of Ca2+ influx. © 2010 Wiley Periodicals, Inc., Inc.
Layer‐specific alterations to CA1 dendritic spines in a mouse model of Alzheimer's disease
Authors: Merino‐Serrais P. , Knafo S. , Alonso‐Nanclares L. , Fernaud‐Espinosa I. , DeFelipe J.
Published: September 2010

Why memory is a particular target for the pathological changes in Alzheimer's Disease (AD) has long been a fundamental question when considering the mechanisms underlying this disease. It has been established from numerous biochemical and morphological studies that AD is, at least initially, a consequence of synaptic malfunction provoked by Amyloid β (Aβ) peptide. APP/PS1 transgenic mice accumulate Aβ throughout the brain, and they have therefore been employed to investigate the effects of Aβ overproduction on brain circuitry and cognition. Previous studies show that Aβ overproduction affects spine morphology in the hippocampus and amygdala, both within and outside plaques (Knafo et al., (2009) Cereb Cortex 19:586‐592; Knafo et al., (in press) J Pathol). Hence, we conducted a detailed analysis of dendritic spines located in the stratum oriens and stratum radiatum of the CA1 hippocampal subfield of APP/PS1 mice. Three‐dimensional analysis of 18,313 individual dendritic spines revealed a substantial layer‐specific decrease in spine neck length and an increase in the frequency of spines with a small head volume. Since dendritic spines bear most of the excitatory synapses in the brain, changes in spine morphology may be one of the factors contributing to the cognitive impairments observed in this AD model. © 2010 Wiley‐Liss, Inc.
Two New Sesquiterpenes from the Fungus Stereum sp.
Authors: Liu Fang‐Fang , Li Guo‐Hong , Yang Zhong‐Shan , Zheng Xi , Yang Yue , Zhang Ke‐Qin
Published: September 2010

Two new sesquiterpenes, stereumin F (1) and stereumin G (2), together with two known compounds (3β,5α,22E,24R)‐5,8‐epidioxyergosta‐6,22‐dien‐3‐ol (3) and 4‐(2‐hydroxyethyl)phenol (4), were isolated from the AcOEt extract of the culture broth and the MeOH extract of the mycelium of the fungal strain Stereum sp. CCTCC AF 207024. Their structures were established on the basis of spectral analyses.
Study on the Constituents of Roots of Aceriphyllum rossii
Authors: Kim Van Le Thi , Hung Tran Manh , Kim Soo Hyun , Kim Jin Cheol , Na MinKyun , Jung Hyun Ju , Kwack Seung Jun , Kweon Kee Tae , Choi Jae Sue , Lee Hyeong Kyu , Bae KiHwan , Min Byung‐Sun
Published: September 2010

A new stereoisomer of a tetrahydrofuranoid lignan, acerifuranoid A (1), and two new oleanane‐type triterpenoids, aceriphyllic acids J and K (2 and 3), were isolated from the roots of Aceriphyllum rossii. Their structures were elucidated on the basis of spectroscopic analyses and chemical evidence. These isolated compounds exhibited weak cytotoxic activity against various cancer cell lines with IC50>150 μM.
Two New Sesquiterpene Polyol Esters from Celastrus angulatus
Authors: Wei Shao‐Peng , Wu Wen‐Jun , Ji Zhi‐Qin , Zhang Ji‐Wen , Guo Yong‐Ze , Xue Jian
Published: September 2010

Two novel sesquiterpene polyol esters with a dihydro‐β‐agarofuran (=(3R,5aS,9R,9aS)‐octahydro‐2,2,5a,9‐tetramethyl‐2H‐3,9a‐methano‐1‐benzoxepin) skeleton, (1α,2α,4β,8α,9α)‐1,2,8,12‐tetrakis(acetyloxy)‐9‐(furoyloxy)‐4‐hydroxydihydro‐β‐agarofuran (1) and (1α,2α,6β,8α,9α)‐1,2,6,8,12‐pentakis(acetyloxy)‐9‐(benzoyloxy)dihydro‐β‐agarofuran (2), and the three known compounds (1α,2α,4β,6β,8α,9β)‐1,2,6‐tris(acetyloxy)‐9‐(benzoyloxy)‐4‐hydroxy‐8,12‐bis(isobutyryloxy)dihydro‐β‐agarofuran (3), (1α, 2α,4β,6β,8α,9β)‐1,2,6,8‐tetrakis(acetyloxy)‐9‐(furoyloxy)‐4‐hydroxy‐12‐isobutyryloxy)dihydro‐β‐agarofuran (4), and (1α,2α,4β,6β,8α,9β)‐1,2,6‐tris(acetyloxy)‐9‐(benzoyloxy)‐4‐hydroxy‐8‐(isobutyryloxy)‐12‐[(2‐methylbutanoyl)oxy]dihydro‐β‐agarofuran (5) were isolated from the root bark of Celastrus angulatus. Their chemical structures were elucidated by analyses of their MS and NMR data.