bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Non-Surgical Periodontal Treatment of Generalized Chronic Periodontitis on Quality of Life
Authors: BEHRAVAN Hassan , ÖNDER Canan , KURGAN Sivge , ALTINGÖZ Sema Merve , GURGAN Cem , GÜNHAN Meral
Published: August 2022

Aim: In recent years, after treatments variety of measurement scales are used to record the extent and impact of the treatment on quality of patient’s life. Among these scales, Oral Health Impact Profile (OHIP-49) and a shorter version of that OHIP-14 are the most comprehensive, accessible and common ones. Our aim was to evaluate the effect of non-surgical periodontal therapy on quality of generalized chronic periodontitis patients’ life by using the Turkish version of the OHIP-14 scale (OHIP-14-TR).

Method: 58 patients (37 men and 21 women) diagnosed with generalized chronic periodontitis and requiring non-surgical periodontal therapy were recruited in this study. All patients were asked to fill in a form containing demographic, socio-economic information, reason of dental visit and oral hygiene habits. Clinical periodontal parameters (Plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP)) were recorded at baseline, and one month after treatment. Non-surgical periodontal treatment containing scaling and root planning was performed during one week in two seperate sessions. OHIP-14-TR questionnaires have been filled out before and after treatment.

Results: There were significant decreases in all periodontal parameters and OHIP-14-TR one month after non-surgical periodontal treatment (p0.05). Significant positive correlation was found between physical pain, and BOP and PPD. After periodontal treatment, BOP, PPD, and physical pain decreased.

Conclusion: According the results of this study, it was revealed that non-surgical periodontal treatment was effective in improving the quality of life of patients.
EDUCAÇÃO EM SAÚDE NA PREVENÇÃO DE QUEDAS PARA IDOSOS COM HIPERTENSÃO ARTERIAL
Authors: De Sousa Tainara Chagas , Ferreira Luzia Camila Coelho , Moreira Rafaella Pessoa , Cavalcante Tahissa Frota , Morais Huana Carolina Cândido
Published: August 2022

Resumo: Objetivo: relatar a experiência de ações educativas sobre a prevenção de quedas para idosos com hipertensão arterial. Método: trata-se de um relato de experiência sobre encontros educativos acerca da prevenção de quedas, realizados para 36 idosos com hipertensão arterial acompanhados pela atenção primária no interior cearense. Durante os encontros, utilizou-se o jogo adaptado “Não deixe a vovó cair”. Além disso, houve a confecção de folders e cartazes para fornecer as informações de forma mais ilustrativa. Resultados:percebeu-se que a aplicação do jogo estimulou os idosos a refletirem sobre situações inadequadas em seu ambiente domiciliar que podem ser adaptadas para evitar quedas. Alguns idosos apresentaram dificuldades cognitivas quando solicitados a identificarem os fatores de riscos presentes em cada cômodo da casa, mas após os exemplos do cotidiano, foram capazes de entender as situações do jogo. Com as orientações, os idosos puderam compreender a relevância dos fatores que favorecem o risco de quedas. Conclusão: Conclui-se que a educação em saúde é uma potencial estratégia para a realização de atividades educativas sobre a prevenção de quedas em idosos com hipertensão arterial. Para isso, torna-se importe a utilização metodologias lúdicas como jogos e materiais que proporcionem a fixação das orientações como os folders.
ANÁLISE DA CULTURA DE SEGURANÇA DO PACIENTE EM UMA MATERNIDADE PÚBLICA NO NORTE DO BRASIL
Authors: Araújo Laís Xavier de , Pereira Priscilla Perez da Silva , Pontes Daniela Oliveira , Almeida Rosa Maria Ferreira de , Santana Flaviane Regis de Souza , Deus Josimeire Cantanhêde de , Souza Arghia Gigli de , Ramos Ana Carolina Mendes Coelho
Published: August 2022

Objetivo: Analisar a cultura de segurança do paciente entre os profissionais de saúde de uma maternidade pública na região Norte do Brasil. Método: Estudo transversal, realizado em uma maternidade de baixo risco da capital de Rondônia, em 2019, com 70 profissionais atuantes no serviço. Foram analisadas as 12 dimensões da cultura de segurança do paciente por meio do questionário Hospital Survey on Patient Safety Culture. Foi realizada análise descritiva e teste Qui-quadrado de Pearson para verificar associação estatística entre as variáveis do estudo. Resultados: Os resultados apontaram que, a maioria dos participantes era do sexo feminino, média de idade de 39 anos e possuíam pós graduação. Na avaliação das 12 dimensões da Cultura de Segurança do Paciente verificou- se apenas uma área de fortaleza com mais de 75% de respostas positivas – “Expectativas e ações do supervisor/chefe para a promoção da segurança do paciente”. Houve diferença estatisticamente significativa entre o tempo de trabalho na instituição e o modo com que esse participante qualificou a segurança do paciente. Conclusão: Substituir a cultura punitiva pelo aprendizado com os erros e estimular a comunicação interprofissional são ações que podem ser trabalhadas pelo serviço na busca de uma cultura positiva.
ESTILOS DE APRENDIZAGEM E GESTÃO DO TEMPO: APLICAÇÃO NA PÓS-GRADUAÇÃO DURANTE A PANDEMIA DA COVID-19
Authors: Barata Rosinete Souza , Moura Ricardo Henrique Gonçalves de , Garrido Carolina De Melo Contreiras , Felzemburgh Ridalva Dias Martins , Ferraz Mariana Oliveira Antunes , Schulz Renata Da Silva
Published: August 2022

Objetivo: descrever sobre a aplicação das teorias de estilos de aprendizagem e gestão do tempo na organização dos estudos em programa de pós-graduação stricto sensu em Enfermagem e Saúde no cenário do ensino remoto durante a pandemia da Covid-19. Método: relato de experiência durante oficina realizada em outubro de 2021 com a finalidade de orientar os estudantes na organização dos estudos de modo a conciliar atividades acadêmicas e outras demandas sob o olhar da Teoria dos Estilos de Aprendizagem e da Teoria Tríade do Tempo. Resultados: verificou-se que a organização dos estudos e gestão do tempo têm impactos positivos na vida acadêmica e saúde mental do estudante e nessa organização há distintos elementos envolvidos como: elementos de distração, estilo de aprendizagem, cronograma de estudo, local e técnica de estudo. Considerações Finais: o estudo confirma que a organização dos estudos tem impacto positivo na produção acadêmica e saúde mental dos estudantes em programa de pós-graduação no cenário do ensino remoto durante a Covid-19 e que a aplicação do estilo de aprendizagem e gestão do tempo potencializam seus resultados.
Perfil e Sazonalidade dos Usuários Frequentes no Serviço de Atendimento Móvel de Urgência
Authors: Dos Santos Mahyara Pereira , Castro Meire Cristina Novelli e , Meneguin Silmara , Almeida Priscila M. Vieira de
Published: August 2022

Objetivo: Analisar o perfil e sazonalidade dos usuários frequentes do Serviço de Atendimento Móvel de Urgência. Metodologia: Pesquisa descritivo-exploratória, quantitativa, realizada por meio da análise das fichas dos atendimentos realizados entre 01/06/2018 a 31/05/2019 por um Serviço de Atendimento Móvel de Urgência. Resultados: No período do estudo, houve 7621 atendimentos no serviço, sendo 6557 incluídos no estudo. Os usuários frequentes, aqueles atendidos mais do que uma vez pelo serviço, foram identificados em 2012 casos (30,68%). A idade média desses pacientes foi de 53,29 anos sendo a maioria do sexo feminino (55,07%). A principal demanda foi em decorrência de queixas clínicas (72,14%), seguida pelas psiquiátricas (16,94%). As queixas clínicas e as psiquiátricas foram prevalentes, respectivamente, nos períodos da manhã e da tarde (p<0,0001) e no inverno e na primavera (p=0,0030). O aumento da idade mostrou-se um fator de risco nas queixas clínicas (OR=1,040) e protetor nas queixas psiquiátricas (OR=0,971). Conclusão: Os atendimentos frequentes foram majoritariamente de natureza clínica e psiquiátrica. Houve relação entre período do dia nos atendimentos psiquiátricos, sendo o aumento da idade um fator protetor nestes casos, e sazonalidade com os casos clínicos, sendo o aumento da idade um fator de risco.
Novel RP-UPLC Method Development and Validation for Simultaneous Quantification of Emtricitabine, Tenofovir and Efavirenz in Bulk and Tablet Dosage Forms
Authors: Kumar Konidala Sathish , Samineni Ramu , Venkateswara Rao Yamarthi , Chimakurthy Jithendra , Sucharitha Kolakaluri Chaitanya , Korrapati Vishali
Published: August 2022

Objective: The objective of this work is to develop a precise, accurate and validated reverse phase ultra-performance liquid chromatographic technique for effective simultaneous determination of Emtricitabine, Tenofovir and Efavirenz in bulk and tablet formulation. Method: Separation of the selected drugs was optimized after several trials including changing mobile phase and its composition, stationary phase, flow rate, column temperature, etc. Finally the separation of drugs was achieved on BEH C18 column using a mixture of methanol and phosphate buffer having pH 3.5 in the ratio of 65:35 v/v as mobile phase with flow rate of 0.3 ml/min and the analytes were detected at a wavelength of 260 nm. Results: The developed method was validated by determining the parameters like linearity, system suitability, recovery, precision, specificity, robustness, ruggedness, LOD, and LOQ as per the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines. The system suitability parameters were within the limits, retention times (Rt) for Emtricitabine, Tenofovir and Efavirenz were found to be 0.432, 0.671, and 2.772 min respectively. The method showed linearity between the concentration range of 10-50 μg/ml for Emtricitabine (r2= 0.9987), 15-75 μg/ml for Tenofovir (r2= 0.9983) and 30-150 μg/ml for Efavirenz (r2= 0.9982). The percentage recovery results at 50%, 100% and 150% of Emtricitabine, Tenofovir and Efavirenz were found to be in the range of 99.45 % - 100.15 %. Since there was no interference due to excipients and mobile phase, the method was found to be specific. The assay results of the combined tablet dosage form by the developed method were identified as in good agreement with the acceptance limit. Conclusions: The current method was proved to be effective for routine simultaneous determination of Emtricitabine, Tenofovir and Efavirenz in bulk and tablet formulation.
Molecular Docking studies of THC-HCA on Cancer Receptors
Authors: Kumar S Narendra , D M Chetan , Hiremath Lingayya , Kumar Srivastava Ajeet , P L Muralidhara , R Jyothsana , Pravin Iyer Rithika , Pravin Iyer Ruchika
Published: August 2022

Cancer is a group of diseases which involves abnormal cell growth that can spread to other parts of the body. There are certain characteristics that are required to produce a malignant tumour. They include: Avoidance of programmed cell death and uncontrolled cell division to name a few. The progression from normal cells to cells that can form a detectable mass to outright cancer involves multiple steps known as malignant progression. Cannabinoids are among the treatment available. Recent research has shown that cannabinoid coupled with hydroxy citric acid can be used in the treatment of melanoma. Hydroxy citric acid is a derivative of citric acid well known for its anti-obesity and anti-inflammatory property. The current project involves the coupling of tetrahydrocannabinol with hydroxy citric acid to develop a novel drug molecule for potential cancer treatment. Simulation tool like Argus lab is used to construct the 3D structure of the novel drug. Autodock was used to bind the drug with the receptors like TRPV1, CB1, CB2, 4QO1 and 2YGB.
Study the predictable correlation between recurrent abortion with the level of proteins S, C, age and blood groups in women in AL-Najaf governorate, Iraq
Authors: AL-Hadrawi Maysoon Khudair. , Hasan Mohsin Ahmed Abdul , AL- Hadrawai Kais K. , Nasser Noor Ismeal , Metiab Ali k.
Published: August 2022

Context: Repeated pregnancy loss is causing great distress to couples and undermining their confidence in achieving reproductive success in the future. A doctor can usually diagnose the cause and manage it directly, but in some cases, the cause is not known. Aim: This study aims to investigate whether there is a correlation between recurrent miscarriage and the level of protein S, C, age and blood groups in women who have experienced recurrent miscarriage without identifying a cause for this condition. Material and methods: one hundred twenty from infected women by recurrent abortion for unknown causes were classified according to age groups. Diagnosed blood group by using a specific kit for Biorex diagnostic Limited (the United Kingdom, 2016). The concentration of protein S and C were calculated by using the equipment produced by the AESKU.DIAGNOSTIC (Germany) Statistical analysis: the statistical analyses of the data were performed by using the (SPSS) 20.0 software package. We used the following analyses, frequencies, percentage, mean, stander diversion and Pearson correlation to identify the potential correlation between the miscarriage and the level of protein S, C, age and blood groups, the p-value of less than 0.05 was considered significant. Results: The study showed that out of a total of 120 women, who suffer from recurrent abortion, 82/120 have a decrease in the level of C protein, 96/120 have a decrease in the level of S protein and 74\120 have low level of both proteins C&S. The results were statistically significant (P=0.000, P=0.000 and p=0.000), There was an intermediate direct correlation between recurrent abortion and the level of proteins C and S (rp= 0.545, rp= 0.643), also there was correlation between the level of protein S and the level of protein C (rp=0.713). It was also found that there was no correlation between age and blood groups with cases of recurrent abortion in women the results was statistically non-significant (rp= - 0.084, p= 0.279; rp= 0.108, p=0.159). Conclusion: There are several reasons for the occurrence of recurrent abortion, including what is caused by microbial infections, or it may be caused by certain abnormalities in the reproductive system, etc., also appear to the results of this research, the low level of one of the proteins S, C or both may be a cause in the case of recurrent abortion.
Hepatoprotective Potential of Aqueous Extract of Hibiscus rosasinensis and Butea monosperma against Fe-NTA induced Hepatotoxicity in Rats
Authors: Dayal Ram , Ruhi Ruhi , Kumar Bimlesh , Melkani Indu , Sood Ankita , Kumar Pandey Narendra , kaur Sukhanpreet , Kaur Gagandeep , Singh Saurabh , Singh Baghel Dileep , Joshi Kardam , Patel Dhara , Anupriya Anupriya
Published: August 2022

Hibiscus rosasinensis and Butea monosperma have been traditionally claimed to be protective against liver injury. However, the hepatoprotective effect against iron overload is not yet validated scientifically. The present study was undertaken to evaluate the possible ameliorating effect of aqueous extract of Hibiscus rosasinensis (AQEHR) and Butea monosperma (AQEBM) against ferric nitrilotriacetate (Fe-NTA) induced hepatotoxicity in rats. After extraction, total phenolics and flavonoids content of AQEHR and AQEBM were estimated. Further, antioxidant effect followed by hepatoprotective efficacy of AQEHR and AQEBM were evaluated against chronic iron overload by administering Fe-NTA for 8 successive days to rats in increasing order of doses from 6-15mg Fe/kg. Treatments with both the extracts were started 3 days before the administration of iron and together with iron administration for 8 days. Level of liver function tests, triglycerides, protein, and lipid were recorded. Oxidative biomarkers and histopathology were performed to find out the level of protection by extracts. AQEBM contains a high amount of total phenolic and flavonoids contents and exhibited potent antioxidant effects in all assays. Supplementation of both the extract showed hepatoprotective effect by amelioration of biochemical changes and oxidative biomarkers. AQEBM possesses a higher amount of phenolic components and exhibited better therapeutic potential than AQEHR.
Formulation and evaluation of orlistat loaded microsponges for the treatment of obesity
Authors: Vishvakarma Rahul , Majumdar Arti , Malviya Neelesh
Published: August 2022

The motivation behind this investigation was to design novel drug delivery system containing orlistat micro sponges. Microsponges containing orlistat and Ethyl cellulose/ Eudragit RS 100 prepared by quasi emulsion solvent diffusion (Technique) method. The formulations were prepared step by step increases Drug: polymer ratio. The particle size (Malvern analyzer), Surface Morphology and structure examination (SEM) Production yield, Drug entrapment Efficiency and in vitro drug release studied of microsponges were examined. Shape or surface morphology and topography of the orlistat microsponges were examined by scanning electron microscopy. The drug orlistat disperse in GIT for better therapeutic effect as microsponges disperse freely in GIT. To improve absorption of orlistat so as to enhance bioavailability, micro sponges is used as delivery systems which show better absorption and bioavailability then other dosage form of orlistat. The particle size were prepared microsponges was observed in the range of 50.45 ± 0.85µm to 57.77 ± 1.35µm. The drug entrapment of the orlistat microsponges was observed in the range of 73.23 ± 0.23 to 83.41 ± 1.17 % The in vitro drug release study of the microsponges over 8 hour range from 59.28 ± 0.41% to 73.16 ± 0.89 %. The objective of this research work was to formulation and evaluation of orlistat loaded microsponges for management of obesity disease. Microsponges drug delivery system landscape have been highly and rapidly evolving. They are allowing for novel product form. Microsponges are safe biologically and extraordinary preferred position programmable release. This delivery system are being integrated to optimize the efficacy or free streaming effectiveness treatment.
Unfolding Biomechanism of Dolichos lablab Bean as A Dietary Supplement in Type 2 Diabetes Mellitus Management through Computational Simulation
Authors: Purwanti Elly , Hermanto Feri E. , Prihanta Wahyu , Permana Tutut I.
Published: August 2022

Dietary intervention, particularly legumes consumption, plays a significant role in promoting health status in diabetes mellitus management. As poorly known legumes, Dolichos lablab (DL) is possibly to be one of the dietary options for diabetes intervention. However, the predictive or precise mechanism of DL’s anti-diabetic activity remains inconclusive. This study aimed to determine the nutritional and phytochemical content in addition to anti-diabetic properties of DL. Total protein, crude fat, crude fibers, and gross energy were evaluated, while anti-diabetic properties were predicted using molecular docking according to identified compound from Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) analysis. Screened compound from molecular docking then passed to physicochemical properties and bioactivity prediction using Swiss-ADME and molinspiration, separately. The result showed that DL has high protein fiber and gross energy content with a lower fat percentage. Additionally, DL has numerous phenolic acid and flavonoid compounds according to LC-HRMS analysis. From the docking analysis, fourteen compounds have substantial probability to give the beneficial effect of glucose metabolism regulator and insulin signaling repairers through inhibition of ɑ-amylase, DPP4, and PTP1B. Finally, from the physicochemical properties and bioactivity estimations, 19-Norandrostenedione, 19-Nortestosterone, Icariside B1, Ilicic Acid, and Psilostachyin B have excellent pharmacokinetic properties along with considerable biological activity as enzyme inhibitors and nuclear receptor ligands. In conclusion, nutritional evaluation and molecular docking analysis revealed that DL might serve as a suitable dietary intervention for diabetes mellitus management.
Vestibular anus, a surgical dilemma
Authors:   Aswan University Hospital, Pediatric Surgery Unit, Egypt., Abdelmohsen Sarah Magdy , Abdelazeem Basel ,   McLaren Health Care, Flint/Michigan State University, USA.
Published: August 2022

It is a pleasure for me to draw attention in this issue of your admirable journal to recto-vestibular fistula. Vestibular anus means congenital presence of the anus in the vestibule behind the vaginal orifice. It shares a common wall between the vagina and the rectum. In addition to an abnormal cosmetic appearance, it leads to recurrent attacks of urinary tract and vaginal infections. In adult female patients, it leads to dyspareunia. Several techniques have been described for the treatment of this type of anomaly, however; the postoperative continence is not always satisfactory. Optimal surgical repair would be easy to assess minimum dissection to spare pelvic nerves and guide the rectal pouch through the muscles of continence and intact sphincter [1]. The surgeon must cautiously during surgical separation of the posterior vaginal wall from the anterior rectal wall to avert rectal wall tear.
A solitary granular cell tumor of stomach: A rare entity
Authors:   Associate Professor (GI & Liver Division), Seth G.S. Medical College & KEM Hospital, Mumbai India., Chaturvedi Rachana , Naik Pooja ,   Seth G.S. Medical College & KEM Hospital, Mumbai, India.
Published: August 2022

Granular cell tumor (GCT) is uncommon, originates from Schwann cell and is usually benign. It is most commonly seen in skin and subcutaneous tissue of chest and upper extremity, tongue, breast, female genital tract and respiratory tract. Involvement of Gastrointestinal Tract (GIT) is seen only in 8% of cases and still rarer in stomach; more frequent in esophagus followed by colon. Most of GCTs are reported to be synchronously associated with the similar tumor at esophagus or other gastrointestinal location [1]. Here we report a rare case of solitary GCT of stomach.
Origin and properties of hepatocellular carcinoma cell lines
Authors:   Department of Biochemistry, Center of Excellence in Molecular Biology & Regenerative Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India., Puttahanumantharayappa Lakshana D , Sannappa Gowda Nirmala G ,   Department of Biochemistry, Center of Excellence in Molecular Biology & Regenerative Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India., Shiragannavar Varsha D ,   Department of Biochemistry, Center of Excellence in Molecular Biology & Regenerative Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India., Santhekadur Prasanna K ,   Department of Biochemistry, Center of Excellence in Molecular Biology & Regenerative Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
Published: August 2022

The liver is one of the vital organs in human beings. It is responsible for several functions such as energy homeostasis, detoxification, regulating blood sugar levels, protein synthesis, bile acid secretion, cholesterol production and glycogen storage. Hepatocellular Carcinoma (HCC) alternately referred to as malignant hepatoma accounts to ~75% of all liver cancers and its resistance to therapeutics at progressed stages makes it lethal. Some of the main causes of HCC include HBV, HCV, aflatoxin, chronic alcoholism, excess nutrition, liver cirrhosis, iron over load, Wilson's disease, and type 2 diabetes. It is essential to detect the underlying causes of HCC at the cellular and molecular levels to develop drugs and find a potential cure for the disease. Several ongoing studies on HCC cell lines help to understand the gene expressions, multiple signaling pathways and differential drug responses to HCC. This review article provides insights to the possible molecular pathways involved in the origin of commonly used HCC cell lines and the signals that are functionally active in them. Keywords: hepatocellular carcinoma; malignant; cell lines; molecular pathways; Msignals.
Eficacia, seguridad y tolerabilidad de la combinación fija de ibuprofeno (400 mg) y cafeína (100 mg) frente a la de ibuprofeno, cafeína y placebo en el dolor agudo
Authors: Weiser Thomas
Published: August 2022

¿Tiene ventajas la combinación de ibuprofeno y cafeína respecto al ibuprofeno solo en el tratamiento del dolor agudo? Un estudio aleatorizado, controlado con placebo y con doble enmascaramiento comparó la eficacia, seguridad y tolerabilidad de una combinación de ibuprofeno + cafeína con la de las sustancias por separado o con el placebo en el dolor agudo de moderado a intenso. La combinación fue superior a todos los demás tratamientos en relación con el alivio del dolor durante 8 horas, el inicio de la acción, la tasa de respuesta y la toma de un analgésico de rescate (de escape); se demostró la seguridad y la tolerabilidad. Por lo tanto, la combinación de ibuprofeno y cafeína es una opción de tratamiento superior en comparación con el ibuprofeno solo para el tratamiento del dolor agudo.
A fix dózisú ibuprofén (400 mg) és koffein (100 mg) kombinációjának hatásossága, biztonságossága és tolerálhatósága ibuprofénnel, koffeinnel és placebóval összehasonlítva akut fájdalomban
Authors: Weiser Thomas
Published: August 2022

Van-e előnye az ibuprofén és a koffein kombinációjának az ibuprofénnel szemben az akut fájdalom kezelésében? Egy randomizált, placebo-kontrollos, kettős-vak vizsgálat összehasonlította az ibuprofén + koffein kombinációját akut, mérsékelt vagy súlyos fájdalom esetén a különálló hatóanyagokkal vagy a placebóval. A kombináció a 8 órán át tartó fájdalomcsillapítás szempontjából jobb volt az összes többi kezelésnél, a hatás kezdete, a válaszadók aránya és a mentő (menekülési) fájdalomcsillapító bevitele tekintetében; bizonyították a biztonságosságot és a tolerálhatóságot. Így az ibuprofén és a koffein kombinációja jobb kezelési lehetőség az akut fájdalom kezelésére az ibuprofénnel szemben.
Akutní kašel: poprvé jasné doporučení pro ambroxol při symptomatické léčbě
Authors: Mueck Tobias
Published: August 2022

Podle pokynů Německé respirační společnosti je kašel při akutním nachlazení bez klinických indikací pneumonie nebo jiných varovných příznaků vhodný pro samoléčbu. Stěžejní pro „akutní“ klasifikaci je délka trvání – do dvou týdnů. Autoři ze svého vyhodnocení randomizovaných, kontrolovaných studií vyvodili, že ambroxol (stejně jako několik rostlinných léčivých přípravků) zkracuje trvání kašle a/nebo snižuje intenzitu kašle při akutní bronchitidě. Pro suchý, obtížný kašel spojovaný s infekcí horních cest dýchacích autoři pokynů doporučují dextromethorfan.
Akut köhögés – végre egyértelmű ajánlás az ambroxol használatára tüneti kezelésként
Authors: Mueck Tobias
Published: August 2022

A Német Pneumológiai és Légzőszervi Társaság irányelvei szerint az akut nátha és köhögés, tüdőgyulladásos vagy egyéb figyelmeztető jelek nélkül, az öngyógyszerezés területe. Az időtartam – legfeljebb két hét – kulcsfontosságú az „akut” besorolás szempontjából. A randomizált, kontrollált vizsgálatok értékeléséből a szerzők arra a következtetésre jutottak, hogy az ambroxol (mint számos növényi gyógyszer) lerövidíti a köhögés időtartamát és/vagy csökkenti a köhögés intenzitását, akut bronchitis esetén. Az irányelv szerzői felső légúti fertőzéssel járó száraz, zavaró köhögésre a dextrometorfánt ajánlják.
Ambroxol reduce la frecuencia de la tos (de día y de noche), mejorando la capacidad de concentración y la calidad de vida
Authors: Mueck Tobias
Published: August 2022

El estudio se realizó en oficinas de farmacia y en él se entrevistó a los clientes que habían utilizado una de las cuatro formas farmacéuticas diferentes de ambroxol para tratar la tos aguda. Los resultados ilustraron los beneficios terapéuticos del ambroxol cuando se usa en la automedicación de la tos aguda. Las diferentes formas farmacéuticas mostraron una eficacia comparable.
L'ambroxolo riduce la frequenza della tosse (giorno e notte), favorendo così la capacità di concentrazione e migliorando la qualità della vita
Authors: Mueck Tobias
Published: August 2022

Ai fini dello studio sono stati intervistati clienti di varie farmacie che avevano utilizzato una delle quattro formulazioni dell'ambroxolo per il trattamento della tosse acuta. I risultati hanno illustrato i benefici terapeutici dell'ambroxolo nell'ambito dell'automedicazione della tosse acuta. Le diverse formulazioni sono risultate paragonabili in termini di efficacia.
Estratto di radice di altea e miele: sollievo dalla tosse grazie all'azione mucoprotettiva
Authors: Mueck Tobias
Published: August 2022

Lo studio sperimentale ha esaminato le proprietà bioadesive degli sciroppi per la tosse contenenti estratti di piante con o senza aggiunta di miele. Gli autori dello studio hanno concluso che l'aggiunta del miele ha esteso il tempo di adesione alla mucosa nel modello utilizzato, migliorando così il sollievo fisico-chimico dall'irritazione. Gli sciroppi esaminati hanno mostrato un'ulteriore azione calmante, causando una riduzione della permeabilità della mucosa alle sostanze nocive irritanti; anche in questo caso, l'aggiunta del miele ha contribuito all'effetto complessivo.
Características específicas de la mujer en los episodios de estreñimiento y en su tratamiento
Authors: Landes Sabine
Published: August 2022

El estreñimiento no solo repercute en el tránsito intestinal diario, sino también en el bienestar de las personas que lo padecen. Una encuesta realizada en internet a más de 5.000 personas demostró que las mujeres suelen verse más afectadas (tanto física como emocionalmente) que los hombres. En cuanto al tratamiento, los datos de los estudios sobre los laxantes bisacodilo y picosulfato de sodio demostraron que las mujeres respondían más rápidamente a los laxantes y, en relación con su calidad de vida, obtenían mayores beneficios del tratamiento que sus homólogos masculinos.
Farmacocinética del ibuprofeno: comparación de la combinación fija de ibuprofeno y cafeína con lisinato de ibuprofeno o ácido de ibuprofeno
Authors: Weiser Thomas
Published: August 2022

Los analgésicos que contienen ibuprofeno en su forma ya soluble (como lisinato) se desarrollaron con el objetivo de garantizar un alivio más rápido del dolor que el que se daba con ibuprofeno en su forma ácida mediante una absorción más rápida en el tracto gastrointestinal. Dado que el nivel de llenado gástrico puede influir significativamente en la absorción, dos estudios investigaron la farmacocinética del lisinato de ibuprofeno y del ácido de ibuprofeno (combinado con cafeína) con el estómago vacío (en ayunas) y después de un desayuno estándar. La absorción del ibuprofeno como lisinato fue más rápida solo cuando se tomaba con el estómago vacío; después de un desayuno estándar, el tiempo transcurrido hasta alcanzar los niveles plasmáticos máximos con el ácido de ibuprofeno (con cafeína) fue realmente más corto que con el lisinato de ibuprofeno. Dado que los analgésicos no suelen tomarse con el estómago vacío, esto reduce las supuestas ventajas del lisinato de ibuprofeno.
Recomendaciones generales para el tratamiento del dolor abdominal (en el síndrome del intestino irritable)
Authors: Weiser Thomas
Published: August 2022

El dolor abdominal es frecuente y empeora la calidad de vida. Muchas sociedades especializadas de todo el mundo han formulado directrices sobre el tratamiento del síndrome del intestino irritable y todas ellas mencionan los antiespasmódicos para el tratamiento del dolor abdominal. Sin embargo, las principios activos que se utilizan dependen de las opciones de tratamiento disponibles. Cabe destacar que muchas directrices recomiendan explícitamente el butilbromuro de hioscina y el aceite de menta, mientras que el uso de analgésicos no es una opción.
Raccomandazioni delle linee guida per il trattamento del dolore addominale (associato a sindrome dell'intestino irritabile)
Authors: Weiser Thomas
Published: August 2022

Il dolore addominale è un disturbo comune in grado di compromettere la qualità della vita. Numerose organizzazioni specializzate in tutto il mondo hanno formulato delle linee guida per il trattamento della sindrome dell'intestino irritabile, le quali raccomandano tutte l'uso di antispastici per il trattamento del dolore addominale. Tuttavia, la specifica sostanza utilizzata dipende dalle opzioni terapeutiche disponibili. Vale la pena notare che numerose linee guida raccomandano esplicitamente N-butilbromuro di joscina e olio di menta piperita, mentre l'uso degli analgesici non è contemplato.
Súlyos stresszel küzdő és hypomagnesaemiában szenvedő egészséges felnőttek számára kedvező a magnézium és B6-vitamin kombinációja
Authors: Eberlin Marion
Published: August 2022

Ez a randomizált, egyszeres vak klinikai tanulmány az önmagában alkalmazott magnéziumpótlás vagy a magnézium B6-vitaminnal való együttes adásának hatásait vizsgálta. Míg közepes stressz esetén nem voltak szignifikáns különbségek a vizsgálat anyagok hatásai között, a hypomagnesaemiában és a súlyos vagy nagyon súlyos stresszben szenvedő betegek számára előnyös volt a magnézium és a B6-vitamin kombinációja.
Tratamiento del dolor agudo: comparación de la eficacia de lisinato de ibuprofeno con la de ibuprofeno
Authors: Weiser Thomas
Published: August 2022

Cuando queremos tratar el dolor buscamos un tratamiento que proporcione un alivio rápido y eficaz. Un estudio con doble enmascaramiento y controlado con placebo investigó la eficacia, seguridad y tolerabilidad del lisinato de ibuprofeno, el ácido de ibuprofeno y el placebo en el dolor agudo tras la extracción de muelas del juicio. El lisinato de ibuprofeno y el ácido de ibuprofeno fueron bien tolerados de manera similar y tuvieron una eficacia similar en cuanto al alivio del dolor durante seis horas. Pero, en contra de lo esperado, el inicio de acción del lisinato de ibuprofeno no fue significativamente más rápido que el del ácido de ibuprofeno.
Akut fájdalom kezelése: az ibuprofén-lizinát és az ibuprofén hatásosságának összehasonlítása
Authors: Weiser Thomas
Published: August 2022

A fájdalom kezelése során gyors és hatékony enyhülésre van szükség. Kettős vak, placebokontrollált vizsgálat foglalkozott az ibuprofén-lizinát, az ibuprofén-sav és a placebo hatékonyságával, biztonságosságával és tolerálhatóságával akut fájdalom esetén, bölcsességfog kihúzását követően. Az ibuprofén-lizinát és az ibuprofén-sav hasonlóan jól tolerálhatók és hat órán át hasonlóan hatékonyak voltak a fájdalomcsillapítás szempontjából. De az elvárások ellenére az ibuprofén-lizinát hatásának kifejtése nem volt lényegesen gyorsabb, mint az ibuprofén-savé.
Nedávná metaanalýza účinnosti silice máty peprné při syndromu dráždivého tračníku
Authors: Weigmann Harald
Published: August 2022

Metaanalýza prokázala, že silice máty peprné je účinný a bezpečný léčivý přípravek k léčbě příznaků syndromu dráždivého tračníku. V sedmi klinických hodnoceních byla silice máty peprné jednoznačně superiorní vůči placebu, pokud jde o zlepšení obecných příznaků syndromu dráždivého tračníku. Pokud jde o nežádoucí účinky, nebyl zjištěn žádný statisticky významný rozdíl mezi silicí máty peprné a placebem.
Endormez-vous rapidement – réveillez-vous revigoré !
Authors: Schuett Tanja
Published: August 2022

Différentes causes incluant le stress et une consommation de médias accrue entraînent une diminution voire une absence totale de sécrétion de mélatonine endogène, suivie de problèmes d'endormissement. D'après l'Autorité européenne de sécurité des aliments (EFSA), si 1 mg de mélatonine est pris peu de temps avant le coucher « la mélatonine aide à réduire le temps d'endormissement ». Des doses plus élevées chez des sujets par ailleurs en bonne santé ne sont pas corrélées à un effet plus important.
De la désactivation du virus in vitro à la pertinence clinique : un spray buccal contenant du glycérol et de la trypsine de morue enraye le rhume
Authors: Schuett Tanja , Loehn Matthias
Published: August 2022

In vitro, la trypsine associée au glycérol a mené à une désactivation de virus courants du rhume. Une étude pilote et une étude comparative multicentrique ont évalué la réduction de la charge virale in vivo et l'amélioration de la qualité de vie après l'utilisation des substances actives sous forme de spray buccal chez des sujets atteints d'un rhume courant. Les résultats ont montré une diminution de la charge virale et de la durée du rhume ainsi qu'une amélioration de la qualité de vie.
Účinnost a snášenlivost ambroxolu u dětí
Authors: Mueck Tobias
Published: August 2022

Přehled shrnoval velký objem publikovaných i dosud nepublikovaných klinických dat ohledně používání ambroxolu u dětí a vyhodnotil jeho výsledky. Bylo prokázáno, že ambroxol je účinnou sekretolytickou léčbou u dětí s akutními i chronickými respiračními onemocněními. Na základě mnoholetého průběžného sledování bezpečnosti ambroxolu bylo stanoveno, že má příznivý profil přínosů a rizik u dospělých i dětí bez rozdílu věku.
Макрогол - лечение на запек, базирано на гайдлайни
Authors: Eberlin Marion , Schuett Tanja
Published: August 2022

Увеличаването на честотата на изхожданията и подобряването на консистенцията на изпражненията играят решаваща роля за облекчаване на запека. Както международните, така и националните насоки признават положителния ефект на макрогол по отношение и на двата параметъра, с голям обем доказателства. Счита се за добре поносим и безопасен. Някои насоки препоръчват стимулантните лаксативи бисакодил и натриев пикосулфат със същата степен на препоръка.
A dexibuprofén bemutatása
Authors: Gazova Andrea , Kyselovic Jan , Koscova Eva
Published: August 2022

A dexibuprofén, az ibuprofén farmakológialag aktív enantiomerje, jó hatásosságot mutat akut és krónikus fájdalomban egyaránt. Ez az áttekintés azokat a klinikai vizsgálati eredményeket foglalja össze, amelyek alátámasztják, hogy a dexibuprofén hatásos és biztonságos alternatíva az ibuprofénnel és más COX-gátlókkal összehasonlítva.
ANTİTÜBERKÜLER AJAN OLARAK N'-(2-(5-((TEOFİLİN-7-İL)METİL)-4-ETİL-1,2,4-TRİAZOL-3-İLTİO)ACETİL)İZONİKOTİNOHİDRAZİT
Authors: GOTSULYA Andrey , ZAZHARSKYİ Volodymyr , PARCHENKO Volodymyr , DAVYDENKO Pavlo , KULİSHENKO Oleh , BRYTANOVA Tetiana
Published: August 2022

Makale, izoniazid ve N'-(2-(5-((teofilin-7-il)metil)-4-etil-1,2,4-triazol-3-iltio)asetil)izonikotinohidrazit. Deri altı uygulama için hesaplanan N'-(2-(5-((teofilin-7-il)metil)-4-etil-1,2,4-triazol-3-iltiyo)asetil)izonikotinohidrazid dozu, etkili ve güvenli bir tüberkülosidal ilaç olarak veterinerlik uygulamaları için beklentiler.
Práctica de los principios rectores sobre empresas y derechos humanos
Authors: Gentile Andrea N , Vázquez Agustina N
Published: August 2022

Dorothée Baumann-Pauly y Justine Nolan, son las editoras de una obra colectiva pensada para todos aquellos que creemos en la implementación efectiva de los Principios Rectores sobre Empresas y Derechos Humanos de la ONU. En el libro, se enfatiza el rol de las empresas y su labor conjunta con los estados para avanzar en el campo del derecho internacional de los derechos humanos, que traerá como resultado múltiples beneficios para los actores involucrados.
ESL Learners’ Perceptions of Online Learning in a Tertiary Institute
Authors: Shamala Benjamin Jeyaraja Shereen , Maniam Mahendran
Published: August 2022

The study explores how learners view the benefits and challenges faced in implementing online learning in ESL classrooms. 53 learners from a private university in Petaling Jaya, Malaysia, were selected to be participants. An adapted questionnaire from a previous study was used to collect data via the Google form. This study employs a quantitative methodology, and the SPSS software was used to analyse the data collected. The findings showed that most learners acknowledged that the introduction of online learning caused obstacles for them. The results reflected learners' unbiased views on the benefits of integrating online learning into ESL institutions. The learners also have difficulty in learning online, and lecturers need to adapt their teaching methods and techniques to address this issue. The study recommends that online learning requires improved resources and technological support from the institution's management.
Frequency of PPD (Para-Phenylenediamine) Allergy in Hair Dye Users in Faisalabad
Authors: Ahmed Shakeel , Abdali Mehwish Khan , Hafeez Filza , Imtiaz Haafiza Hina , Ashfaq Rabia , Malik Aisha
Published: August 2022

Objective: To evaluate the frequency of PPD allergic contact dermatitis in hair dye users in Faisalabad district. Study Design: Cross Sectional study. Place and Duration of Study: Dermatology Outpatient Department of District Headquarter Hospital, Faisalabad from 01-07-2018 to 31-12-2018. Methodology: A cross sectional study was carried out in Dermatology Outpatient Department and 135 patients were included. Male and female patients were included in this study with the age between Results: A total number of 135 patients were included in this study. Gendser distribution showed that there were 110 (81.5%) males and 25 (18.5%) females. The mean age of the patients was 38.04±4.96 years. The mean duration of hair dye use of the patients was 4±1.5 years. There were 92 (68.1%) patients between 30-40 years of age and 43 (31.9%) patients between 41-50 years of age. There were 80 (59.3%) patients between 3-4 years of duration of hair dye and 55 (40.7%) patients between 4-5 years of duration of hair dye. PPD allergic dermatitis was observed in 13 (9.6) patients. There was no association between gender (p=0.232), age (p=0.591) and duration of hair dye use (p=0.676) with respect to PPD allergic dermatitis. Conclusion: Para-phenylenediamineis the commonest cause of hair dye contact dermatitis. Patients can present with a variety of clinical manifestations, including severe reactions. Patch testing remains the gold standard method for confirming PPD allergy. Avoiding future contact with permanent and semi-permanent hair dyes is the standard preventative measure. Keywords: Allergy, Hair, Phenylenediamine, Para-Phenylenediamine.
Prevalence of Anemia in Patients Presenting with Febrile Fits
Authors: Ahmed Khawaja Abrar , Khan Manzoor Ali , Mughal Ishtiaq Ahmed , Shah Syed Zakir Hussain , Zia Mohsna Saeed , Idrees Arzoo
Published: August 2022

Objective: To determine the prevalence of iron deficiency anemia in children with febrile fits. Study Design: Prospective study Place and Duration of Study: Paediatric Medicine, Abbas Institute of Medical Sciences (AIMS) Muzafarabad, AJ Kashmir from 01-04-2021 to 31-03-2022. Methodology: Ninety patients within the age limit of 6 months to 5 years were enrolled. The inclusion criteria were based on the all the children suffering from febrile fits. The enrolled patients’ blood sample comprising of 4cc was pooled and sent for biochemical analysis of hemoglobulin, serum ferritin as well as red cell distribution width. The results of each patients’ reports were used for analysis of their anemia status. Results: The mean age of the patients was 2.6±1.5 years with more boys suffering from febrile fits.. Most of the children belonged to the age group of 1-3 years. The biochemical blood analysis reports revealed that there were 56.25% those children who were suffering from hemoglobulin level less than 10g/dl. The overall prevalence of iron deficiency anemia was found to be 33.75 among boys while 25% within the girls. Conclusion: There is a percentage of iron deficiency anemia as 58.75% in children with febrile fit. Key Words: Prevalence, Anemia, Febrile fits.
Comparison of efficacy in terms of prevention of preeclampsia in patients with calcium intake versus without calcium intake
Authors: Rehman Beena , Akbar Khadija , Ibraheem Irum
Published: August 2022

Objective: To compare the efficacy in term of prevention of preeclampsia in patients with calcium intake versus without calcium intake Materials & Methods: Between April 2021 to October 2021, total 212 Women between 18-35 years of age, having 20 weeks of gestation assessed on LMP, normal blood pressure, no peripheral edema and no proteinuria, women with singleton pregnancy and patients upto para-5 were selected from Department of Obstetrics & Gynecology, MMC General Hospital Peshawar for this randomized controlled trial. Calcium was given to group A while group B was given only routine food. Prevention of preeclampsia in patients with calcium intake versus without calcium intake was assessed. Results: In group A (calcium intake group) & B (without calcium intake group) mean age was 23.15 ± 6.68 years and 23.41 ± 6.05 years respectively. The mean gestational age in group A was 34.71 ± 4.73 weeks and in group B was 33.42 ± 4.83 weeks. There was development of pre-eclampsia in 07 (6.60%) patients and no pre-eclampsia in 99 (93.40%) patients in Group A, in Group B, it was noted in 19 (17.92%) and 87 (82.08%) patients respectively (p=0.012). Conclusion: This study concluded that calcium intake during pregnancy is associated with higher efficacy in preventing pre-eclampsia compared to those without calcium intake. Keywords: Calcium supplementation, proteinuria, high blood pressure.
Role of Triple D Score in Eswl: Our Experience at Urology Department Chandka Medical College Hospital Larkana Pakistan
Authors: Rohra Khob Chand , Shaikh Aamir Ali , Khan Imran , Sohu Safiullah , Bozdar Hameed-Ur-Rehman , Shaikh Nisar Ahmed , Abassi Amanullah
Published: August 2022

Aim: To detect usefulness of triple D score in ESWL (extracorporeal shock wave lithotripsy) for management of renal stone. Methodology: Retrospective Study was conducted at Urology department, CMCTH) at SMBBMedical University Larkana. 50 patients underwent ESWL from 2018 to 2020. All the related data were taken as well as demographic details, history and risk factor from the patients. Routine investigation carried out including Blood CP ESR, Urine DR, Blood sugar, Renal profile, urine culture sensitivity and CT KUB. The stone density, skin-to-stone distance, and stone size were calculated by a radiologist. Results: ESWL was performed on 50 patients with average age of 30± 8 years and a sex ratio (male female) of 1:0.3. The stone-free percentage after the first treatment session was 40 percent and 90 percent on 2nd sitting, based on the triple D score, which included stone size, skin to stone distance, and stone density (HU). The mean stone size was 15.8 mm, the Skin to Stone Distance was 6.4 cm, and the stone density was 594 HU were established respectively. Conclusion: The Triple D Score is easy to compute and reported by radiologist. The use of the Triple D Score in ESWL patients has been shown to improve overall ESWL success rates. Keywords: Extracorporeal, Shock, Wave, Lithotripsy, Renal stone and Triple D score
Marital Dissatisfaction and Depression: A Comparative study among Infertile Couples of Punjab
Authors: Javaid Babar , Ajmal Rahila , Ahmad Umaima , Rashed Azra Abdul , Khan Aujalla Babur , Batool Hifsa , Zainab Farah , Safdar Anila
Published: August 2022

Although most studies on the effects of infertility-related stress focus on individuals, there has been little study on how marital dissatisfaction and co morbid feelings are connected with each other and affect infertile couples. The current study intended to analyze level of marital dissatisfaction and depression among infertile couples. Index of marital satisfaction (IMS) for measuring marital satisfaction and Beck depression inventory (BDI) for measuring depression was used as tool of study.1 The sample of 200 married couples were included 100 couples were fertile and 100 couples were infertile. The results indicated that infertile couples are more martially dissatisfied. Female are more martially dissatisfied. The findings of this study also indicted that there is a positive relationship between marital dissatisfaction and depression among the infertile couples.2 Keywords: Marital dissatisfaction, depression, infertile couples, Punjab