bluuebunny/crossref_metadata_2025 huggingface dataset:
Gestão Portuária e Terminais Marítimos no Contexto Socioambiental
Authors: Akabane Getulio K.
Published: August 2023

A corrente de comércio brasileira seguiu a tendência mundial de desaceleração econômica. Fatores como a pandemia causa pelo COVID-19 e a instabilidade política brasileira e internacional, podem ser citados como variáveis explicativas para esta queda. Apesar do cenário de crise, a balança comercial brasileira, continuou superavitária, apresentando evolução nas exportações e importações do Brasil, com o saldo da balança comercial e o saldo do agronegócio
Estudo de caso: Um olhar qualitativo na psicopedagogia
Authors: Berto Marileth
Published: August 2023

Esta pesquisa tem como objetivo a investigação qualitativa de todos os instrumentos de coleta de dados para apresentar, avaliar e ampliar conhecimentos e estratégias de intervenção das dificuldades de aprendizagem presentes em três alunos, matriculados na rede pública de ensino. Trata-se de uma pesquisa descritiva sob a forma de estudo de caso, sendo os alunos do sexo masculino e com idades variadas. O estudo diagnóstico psicopedagógico totalizou quinze sessões, tendo como referencial teórico os estudos da Psicopedagogia, da Epistemologia Genética, da Psicanálise, da Neurociência, da Psicologia Cognitiva e da Linguística Clínica. Demonstrou-se, além da própria dificuldade na linguagem oral, escrita e aprendizagem em geral, o fenômeno pluri dimensional, que não se situa apenas no aprendente, mas também na família, no professor, nos métodos educacionais, na escola e na sociedade, ou seja, nas múltiplas interações entre eles. Percebeu-se, nesses alunos, melhora significativa no desempenho acadêmico; maior autoconfiança para enfrentar situação de desafio; fluência na organização das ideias, na produção oral de textos e na comunicação; melhora na intra e inter relação; melhor compreensão das suas dificuldades e conhecimento de suas habilidades e modalidade de aprendizagem; maior eficiência da memória verbal e visual.
Academics' link with the university and the relevance of the spirituality and dentistry project during the covid-19 pandemic
Authors: Ramson Kamila Pagel , Fonseca Laura da Silva , Coutinho Rafaela Dias , Mello André Luiz Rodrigues , Pinto Larissa Moreira , Sousa Ezilmara Leonor Rolim de
Published: August 2023

The teaching project "Spirituality and Dentistry: A more humanized care", proposes to the students a broad and more humanized view of the patient as an integral being, as well as demonstrating the role of spirituality in the health-disease process. With the COVID-19 pandemic, the project needed to reformulate its methodology in the face of the reality of remote teaching and thus maintain the link between academics and the university. Thus, this study aimed to verify - through the application of an online questionnaire - whether the methodology employed was satisfactory for the students and whether it had a positive impact on their education and on their bond with the university. The result of the research showed that most students consider that participating in the project activities influenced them in a positive way, both in the personal sphere and in the student/patient relationship at the university. In addition, most students expressed the desire for these teaching activities to continue to take place. It is concluded that the project participants perceived positive differences both in the personal sphere and in the student/patient relationship during the pandemic, because they were involved in the Spirituality and Dentistry teaching project.
Behavioral nutrition applied to the treatment of obesity
Authors: Araújo Chiara Salustri de , Rocha Edenilda Rita Pereira , Castro Giovanna Palomo , Barbosa Karine Oliveira Reder , Flores Nicolle de Souza , Masquio Déborah Landi
Published: August 2023

Obesity is a chronic disease, difficult to control. Even with traditional treatments, such as diet prescription, physical exercise, psychological and drug therapy, the obesity prevalence still continues to increase in worldwide. Thus, behavioral nutrition emerges as a possibility in the control of this disease. This study aimed to understand the role of behavioral nutrition in the treatment of obesity. This is a literature review, conducted through online research in Pubmed, Scielo and Lilacs. Publications from the last ten years in Portuguese and English were included. Reference books in the area were also consulted. The keywords used in the search were: obesity, feeding behavior, mildfulness eating, and intuitive eating. The Boolean AND and OR techniques were used to combine the keywords. Behavioral nutrition is a psychological method, which aims to understand food as a whole, and its main objective is to change negative relationships with food. Thus, the application of behavioral nutrition in obesity treatment can favor the individual to see food as a source of both nutrition and pleasure, but not as an "enemy". It is known that obesity is directly associated with eating-related behavior patterns and changes of satiety recognition. In this sense, behavioral nutrition techniques broaden the range of interventionist possibilities to rescue the recognition of the hunger and satiety cycle and the factors that interferes in this process. Strategies of behavioral nutrition applied in the treatment of obesity include nutritional counseling, intuitive eating, cognitive-behavioral therapy, motivational interviewing, and mindful eating tactics. It is concluded that the application of behavioral nutrition promotes recognition of hunger and satiety signals, and may generate even greater benefits in the treatment of obesity.
Creation of meanings in educational processes: Teaching practices with playful and experimental activities in the teaching of chemistry
Authors: Almeida Amanda Klamer de , Welter Cristiane Backes
Published: August 2023

This chapter aims to share partial results of a research that evaluated the development of a Potentially Significant Teaching Unit on the organic function of alcohol in Chemistry classes, with emphasis on recreational and experimental activities. The execution of the qualitative research, with the case study approach, took place in the months of February and March 2023, in a state school, in the municipality of Bom Jesus, with the participation of students from the third year of high school. The relevance of this study lies in the finding that, by using playful and experimental activities in teaching practices in different educational processes involving the Teaching of Chemistry, we create in students different senses with a view to meaningful learning. The discursive textual analysis allowed the construction of metatext that pointed to the construction of knowledge through the awakening of students' interest by using playful and experimental activities created by teachers in Potentially Significant Teaching Units.
The complexity of the classification: Representation in information science education
Authors: Aganette Elisângela Cristina , Maculan Benildes Coura Moreira dos Santos
Published: August 2023

The teaching-learning of classification for Brazilian Information Science education requires the apprehension of the use of table mechanisms for the formation of a notation or a document classification number and also to understand the variables that must be taken into account in the act of classifying an information resource. We start from the premise that classification is an act inherent to the human being, and, at the same time, involved in complexity, requiring a dimensional knowledge about things for the classification process. Based on Jansen (2008), this study explores the complexity of classification through the discussion of the taxonomy of Chinese animals, presented by Jorge Luís Borges (1981). It seeks to answer the objective question: What lessons can we learn from TAB, which is a classification built for the representation of Chinese animals, in order to contribute to the teaching-learning of classification of documentary resources? To this end, it conducted a narrative review and sought conceptual inputs from Aristotle's hierarchical principles: Rationale; Structure; Disjunction; Thoroughness; Clarity; Uniformity; and Explicitness and precision. These principles were scrutinized and related to the 14 classes of Borges' Taxonomy, enabling a heuristic analysis and pointing out some of the mistakes that can be made in the construction of a classification system.
Young women in technical professional education: Motivations, challenges and future projects
Authors: Quirino Rachel , Gouvea Antônia do Socorro Pinheiro , Soares Fábio da Silveira , Soares Luciana Aparecida Cunha , Silva Rita de Cássia Aguiar e Souza , Grilo Tamyris Ferreira da Silva Bianchi
Published: August 2023

This article addresses the perspectives of three students from the Technical Courses in Buildings, Mechanics and Informatics of an institution of the Federal Network of Professional and Technological Education. Due to their specificities and because they are mostly male careers, theories of gender in EFA and the sexual division of labor supported the critical analysis of the discourses of these young women. The New High School and the National Common Curriculum Base (BNCC) advocate the development of the Life Project at School, aiming, among other functions, to guide the choice of "training itineraries" and favor the personalization of student learning. In the case of Secondary Technical Education (EPTNM) in the integrated modality, students must attend the training itinerary of the general disciplines of the BNCC (Portuguese and Mathematics), together with some other chosen itinerary, compulsorily associated with Technical and Professional Training. However, in addition to fulfilling a legal obligation, knowing the real life projects of young people from EPTNM becomes essential for understanding their motivations, experiences and expectations, in relation to their professional training, the world of work and the continuity of studies. Thus, the results obtained are expected to raise reflections on the relevance of EFA in the lives of young people, taking into account the gender difference, and to promote the debate on public policies for the access and permanence of young people in technical courses.
Subjects and contexts in a self-sustaining systemic game: An analysis of psychosocial profiles of response to different patterns of status inconsistency that compromise development
Authors: Aparicio Miriam
Published: August 2023

The study is part of an investigation in which we address interrelationships between personality and socio-cultural subsystems, starting from a general hypothesis of semi-dependence and semi-autonomy and in an attempt to reveal "patterns" of different psychological responses in their relationship with contextual conditions. It was preceded by another , whose objectives were to observe the behavioral effects against two central patterns: low ethnic status / acquired high in education and low in the occupational; higher / acquired high social status (university) and relatively low in the occupational . The hypotheses were: a) the greater the neuroticism or emotional lack of control, the greater the psychosomatic manifestations; b) Subjects of higher social extraction, but who acquire medium or low relative occupational status (status inconsistency), would make their conflicts more evident through somatization, compared to those from the lower strata (intropunitive response). The latter would project their conflict "outwards", that is, towards the structures (extropunitive response); aspect in which we stop in the study that follows. The findings, among others, showed that greater neuroticism is associated with greater somatization, corroborating findings from northern countries. The sample of the present work was constituted by university women for two reasons: in them these "patterns" could emerge, according to the profile of status inconsistency, since they were a privileged strip of structural underemployment and, therefore, having reached the higher education level, they would suffer from a marked imbalance of status because they could not position themselves in the world of work at a corresponding level. These two different patterns of psychosocial response according to the status inconsistency profile involve: a) the combination of high ascribed status with low acquired status (occupational), which results in intropunitive responses (somatization, self-blame, stress); The reverse "pattern" – status ascribed low/acquired high (educational line) – entails, on the other hand, extroppunishment (nonconformity, rebellion). As far as we are concerned, what was glimpsed in the literature was confirmed. Both psychosocial responses are risky in Argentina, where the percentage of women who, although having a medium-low origin status, reach university but fail to insert themselves satisfactorily into the world of work in a structural framework, not always propitious, increases. The findings were corroborated in research carried out to this day.
Nurse performance in viral oncolytic therapy
Authors: Barreto Everton Rodrigo , Vador Rosana Maria Faria , Meneses Thalita Martins Ferraz
Published: August 2023

Introduction: Viral oncolytic therapy (VOT) is an emerging approach in cancer treatment, which is based on the selective replication of a viral vector inside cancer cells, triggering the death of tumor cells by lysis and the spread of new viral particles to the remaining adjacent malignant cells. However, special care is needed from nurses to manage immune-mediated side effects and provide support and education to patients and their families during treatment. Objectives: To survey the nurse's performance in the face of VOT; propose a model of Systematization of Nursing Care (SNC) with the main nursing diagnoses related to VOT. Methods: This is a qualitative literature review, using as a primary source of research the databases - CAPES, PubMed, Scielo, BVS. Composing a sample of 39 articles relevant to the formulation of this article. Results: Although there is a significant scientific production on nursing care in the oncological context, there are still few studies that specifically address the SNC related to TOV and immunotherapies. In view of this and considering and need to fill this gap, an SNC model is proposed, considering the oncologic patient in the face of a holistic view. Regarding the adverse reactions associated with therapy, it is of paramount importance, and the implementation of SNC as a structured care process can contribute significantly to the excellence of care for cancer patients undergoing this innovative therapy, with the main nursing diagnoses related to OVT Conclusion: The integration of scientific knowledge, clinical skills and a humanized approach strengthens the role of nurses as a fundamental part of the multidisciplinary team in the treatment of cancer through OVT.
Frequency of agenesis of the dorsal wall of the sacrum and its clinical implications
Authors: Aragão José Aderval , Barros Junior Flavio de Souza , Castro Pedro Salgueiro Pereira de , Aragão Felipe Matheus Sant'Anna , Aragão Iapunira Catarina Sant'Anna , Lourenço Bárbara Costa , Nascimento Marcelo Diaz , Souza Gladson Gomes de , Reis Francisco Prado
Published: August 2023

Introduction: The sacrum, formed by the union of the five sacral vertebrae, is positioned at the base of the spine and between the two hip bones. These vertebrae begin to fuse between 16 and 18 years of age and end around 30 years of age. However, in some cases, this structure may suffer anatomical variations, such as agenesis of the dorsal wall of the sacrum, which is a failure in the union of the laminae of the sacral vertebrae. Objective: To analyze the frequency of complete agenesis of the dorsal wall of the sacrum and its clinical and surgical implications. Methodology: A descriptive morphologic and anthropometric study was performed with 45 sacrums of unknown sex and age. The length of the sacral canal was calculated using a digital caliper with 0.01 mm precision. Results: Complete agenesis of the posterior wall of the sacrum was observed in 2 of the 45 sacrums analyzed (4.44%). In the first case, the length of the sacral canal was 110 mm. A triangular shape was observed in the proximal two-thirds and a quadrangular shape in the distal third, with a narrowing between the third and fourth sacral vertebrae. In the second case, the length of the sacral canal was 96 mm, and a triangular shape was observed in the proximal and middle thirds, with a narrowing between S2-S3 and a quadrangular shape in the distal third, with a narrowing between S4-S5. Conclusion: The study of this anatomical variation was necessary, since its occurrence has been persistent and its knowledge can reduce the failures made by clinicians and surgeons in the application of caudal epidural anesthesia, in the diagnosis of low back pain or even in the treatment of congenital diseases, for example meningocele and myelomeningocele.
Indications for anesthetics in the postoperative period of surgery in children
Authors: Drummond Júnior Délio Guerra , Toqueto Tamires Rodrigues , Morais Rainally Sabrina Freire de , Zanoni Rodrigo Daniel , Santos Igor Costa
Published: August 2023

Introduction: Proper management of postoperative pain in children is of utmost importance to ensure patients' comfort and adequate recovery. Anesthetics play a key role in this context, providing effective analgesia and minimizing adverse effects associated with pain. Objectives: To analyze the indications of anesthetics in the postoperative period of surgeries in children, examining the available options, their mechanisms of action, the available scientific evidence and the clinical benefits. Theoretical Framework: The topics covered include the different types of anesthetics used in 4 axes: opioids, local anesthetics, non-steroidal anti-inflammatory drugs (NSAIDs) and adjuvant anesthetics. In addition, it deals with the specific indications for the use of each type of anesthetic, the appropriate doses and the possible side effects. Methodology: The literature search was conducted using the electronic databases PubMed, Scopus and Web of Science. The following English descriptors were used: "postoperative pain management", "children", "analgesics". The inclusion criteria adopted comprised original articles available in full text and written in English. Final Results: Opioids, such as morphine and fentanyl, are frequently used to control severe pain, but should be administered with caution due to possible side effects, such as respiratory depression and excessive sedation. Local anesthetics, such as bupivacaine and lidocaine, are widely used for regional blocks and local analgesia, reducing the need for systemic opioids. NSAIDs, such as ibuprofen and paracetamol, are effective and safe options for mild to moderate pain management with few side effects. Study results indicate that the choice of anesthetic in postoperative surgery in children should be based on individual patient characteristics, type of surgery, pain intensity, and safety profile of the drug.
Influence of cardiovascular risk factors for hereditary hypertension in the homeless population of São Paulo, Brazil
Authors: Oliveira Evelyn , Carneiro Thaís Hudson , Santos Tiffany Marques dos , Muniz Everaldo Soares , Silva-Muniz Claudia Cristina Soares
Published: August 2023

Introduction: Systemic arterial hypertension (SAH) is a public health problem, affecting about 30% of Brazilians. Due to the multifactorial condition, its development, in cases of genetic predisposition, results from the association of genes and environmental factors, such as: sedentary lifestyle, stress, diet, dyslipidemia, obesity, among others. The hypertensive risk factors (RF) in the homeless population (PSR) gain relevance, due to their situation of vulnerability. Objective: To highlight the impact of cardiovascular RF on the development of hereditary hypertension in the homeless. Methodology: Exploratory, cross-sectional and quantitative study. Conducted by pre-structured questionnaire, approved by the Institutional Ethics Committee, CAAE: 21519413.40000.5511, applied between November 2021 and July 2022, in the central region of São Paulo; evaluating the lifestyle and cardiovascular RF of 119 volunteers aged 18 to 60 years, chosen for convenience. Results and Discussion: It was identified that 51.26% reported a family history of SAH. Of these, the average blood pressure was 154x102 mmHg, reporting that 21% suffer from stress, 44% are sedentary and 43% consume high concentrations of sodium in food. Therefore, it is possible to show that the presence of RF determines the tendency to express a hypertensive gene. Such factors play a crucial role in the activation of the sympathetic nervous system and renin-angiotensin system; leading to chemical modifications in the genome, characterizing the onset of SAH in genetically predisposed individuals. Conclusion: We highlight behaviors in the RSP that contribute to the development of hereditary SAH. Consequently, a multidisciplinary approach becomes essential in an attempt to find effective ways to reintegrate this population, aiming to change lifestyle habits. Therefore, just as modifiable RFs influence the manifestation of the disease, environmental stimuli resulting from healthy habits will induce essential changes against the inheritance of the hypertensive trait. Thus, we envision new studies on this theme, strengthening existing public policies and implementing new ones, with the preventive purpose.
Acquired long QT Syndrome: Case report
Authors: Rodrigues António Filipe Pinto , Valentim Bruno Tiago Madeira Morais
Published: August 2023

Long QT syndrome, whether genetic or acquired, is closely associated with arrhythmogenic potential and consequently with syncope or even sudden death. This case report concerns a 77-year-old female who attended the emergency department for right-sided hemiparesis, diagnosed with ischemic stroke. She underwent Holter monitoring for paroxysmal atrial fibrillation, where an increase in the QT interval was found, which triggered a Torsades de Pointes by R on T phenomenon. After investigating the cause, it was found that the origin of the increase in the QT interval was iatrogenic. The drug that was influencing this change was Sotalol, which after being removed from the therapeutic table, reverted the QTc interval to within normal values.
Occurrence of anxiety and depression in patients with peripheral arterial obstructive disease
Authors: Aragão José Aderval , Gomes João Víctor Santos , Silva Larissa Santos , Aragão Felipe Matheus Sant'Anna , Aragão Iapunira Catarina Sant'Anna , Lourenço Bárbara Costa , Reis Francisco Prado
Published: August 2023

Context: neuropsychiatric diseases correlate with biological risk factors, such as systemic arterial hypertension, diabetes mellitus, stroke and cardiovascular diseases, which can lead to suffering, physical and labor disability of the individual. Within this context, there is a high number of cases of peripheral obstructive arterial disease (poad) within a population affected by some depressive disorder, so if untreated, there is a tendency to have a disability and even mortality of this individual, whether for psychic or physical reasons. From this perspective, the theme is extremely relevant due to few studies that address the correlation between anxiety or depression with poad. Objective: to determine the occurrence of anxiety and depression in patients with poad. Methodology: this was a descriptive, observational, cross-sectional study conducted in the vascular surgery department of a tertiary hospital. All patients with poad included in the study for clinical or surgical treatment were evaluated through clinical history, physical examination and through the ankle-brachial index-itb, where systolic blood pressure was measured in the brachial, posterior tibial and pedicle arteries, with the patient in the supine position and at room temperature to avoid peripheral arterial vasoconstriction. The hospital anxiety and depression scale (hads) was used to assess anxiety and depression. Results: the prevalence of anxiety in patients with poad was 24.3%, while depression was 27.6%. It was observed that there was an association of both anxiety and depression in patients with low monthly family income, smoking, systemic arterial hypertension, and were more prevalent in females. Conclusion: there is a high prevalence of anxiety and depression among patients with poad. These when not adequately treated, increase their secondary risks, mainly by increasing the chances of chronic vascular diseases, often predisposing to suicide.
Implementation of extension curricularization in a medical school in Paraíba
Authors: Sá Aralinda Nogueira Pinto de , Deininger Layza de Souza Chaves , Alves Mônica de Almeida Lima , Meira Quênia Gramile Silva , Braga Lucineide Alves Vieira , Pereira Adriene Jacinto , Wanderley Barbara Maria Soares Pereira
Published: August 2023

The curricularization of extension is a prerogative of the MEC based on the regulation by Resolution No. 7, of 2018/MEC, which requires 10% of the undergraduate course workload to be allocated to extension practice. The objective of the study is to present the experience of implementing the curricularization of extension in undergraduate medicine in a private college in the municipality of João Pessoa- PB. The implementation of the Interdisciplinary Practices of Extension, Research and Teaching - PIEPE axis was directed to extension actions for students, in the academic semester 2023.1, with the menu based on the dialogical interaction of the academic community with society; citizen education of students; interprofessional and interdisciplinary training, construction and application of knowledge in society; and articulation between teaching, extension and research. To this end, the teachers hold meetings with the student groups to conduct and guide the writing of six extension projects with scientific rigor, and then the students carried out the actions in the Primary Care territory. The general objective of the projects and the respective actions were chosen based on the health needs identified in fields of practice in health services. In this case, as a problem, they identified the low vaccination coverage in Paraíba, and directed strategic choices that could have an impact on reversing this scenario, such as: active search for users with delayed vaccination schedule, participation in a campaign on the "D-day" of multivaccination, intersectoral articulation in schools, dissemination and information on vaccination on community radios. The products of these actions generated scientific abstracts and students were encouraged to present their academic experiences at events and publication in scientific journals. Thus, it was observed that the module was able to develop communication skills, humanized ethical posture and associate the content learned in theoretical classes taught during the semester; with this the movement of interdisciplinarity was materialized.
The impacts of pesticide use in food production as a potential bioaccumulator in breast milk
Authors: Santo Mateus Lodi do Espírito , Dellalibera-Joviliano Renata
Published: August 2023

The ingestion of food contaminated by pesticides enables several pathologies in humans, such as mainly the bioaccumulation of agrochemicals in breast milk, which highlights a scenario of extreme concern, since these products have a high potential to induce genetic disorders not only in the mother, but also to the baby through breastfeeding. The purpose of this literature review is to highlight the toxicological action that the use of pesticides in agricultural crops provides to newborns through breastfeeding. The methodology used was based on 15 scientific articles, which were found through a search with a filter for the English language and the Boolean operator "AND", being carried out on the Scientific Library Online (SciELO) and PubMed digital platforms, using the descriptors indexed in DeCS / MeSH: Milk human; Agrochemicals; Bioaccumulation; Poisoning. The references were filtered by selecting those published between 2015 and 2023. In view of the results obtained, pesticides that use organochlorines in their composition, such as glyphosate, for example, stand out, which confer easy absorption through the skin. After absorption, the substances can diffuse between membranes and accumulate in organs with high levels of fat, such as breast tissue, mainly. Thus, milk from lactating women promotes the exposure of newborns to these toxicological substances, which can stimulate the development of cancer, leukemia, lymphoma, and brain tumor, followed by the impairment of the immune system. This situation becomes even more alarming because breast milk is the only food that provides the essential nutrients for infant growth, causing not only the pathologies mentioned above but also a series of chronic psychomotor disorders. In conclusion, it can be inferred that the use of pesticides in crops causes a series of permanent and neoplastic disorders to newborns, thus impairing healthy child development.
Sleep deprivation in the puerperal period: Experience report
Authors: Durães Jullyana Almeida , Rocha Samara Atanielly
Published: August 2023

Introduction: Sleep is characterized as a biological rhythm, endogenously generated and controlled by a neural structure located in the hypothalamus, regulated by homeostatic S and circadian C processes. Sleep has an important role for cognitive functioning, skills such as memory, reasoning, psychomotor vigilance and visual perception. The deprivation of this active event of such necessity for the organism causes all systems to be altered and leads to a decline in cognitive functions, with worsening quality of life and productivity. Objective: To discuss the experience lived by the health professional about sleep deprivation in the puerperal period and its impacts on the mother's life as a human being. Methodology: This is an experience report lived by a Nurse from the city, from December 11, 2022 to January 26, 2023 with women living in the city of Januária - MG, using the conversation wheel, sharing experiences and research on social networks. Results: Through the evaluation made, it is possible to identify that sleep interferes with the quality of life of these women. Bringing with it, an exacerbation of anxiety, feelings of anger, depression, suffering, emotional reactivity, fatigue, extreme tiredness, besides the guilt for not being productive as in the period before pregnancy. Conclusion: With this, it is possible to verify that sleep deprivation in the puerperal period is treated as something common, and many women in this period of regulation of pregnancy hormones wear out to the point of collapse. And it is up to the public authorities, together with the support network, community and health services to offer means of support so that they are treated as the situation requires. This experience adds great value for patients and health professionals, as the puerperal woman is treated in a holistic, empathetic and humanized way.
Virtual screening of anticancer activity of chalcones and pyrazolines as potential EGFR, VEGFR, and cytochrome P450 inhibitors
Authors: Wiraswati Hesti Lina , Bashari M. Hasan , Alfarafisa Nayla Majeda , Ma’ruf Ilma Fauziah , Sholikhah Eti Nurwening , Wahyuningsih Tutik Dwi , Satriyo Pamungkas Bagus , Mustofa Mustofa , Satria Denny , Damayanti Ema
Published: August 2023

Context: Metastatic breast cancer is still categorized as an incurable disease because all available therapies are palliative treatments to relieve symptoms and increase life expectancy. Our previous study showed that N-pyrazoline-derived compounds have the potential as an antiproliferative drug in cervical cancer cells line. Therefore, virtual screening is conducted in this study to predict the anticancer potential of several molecules (chalcone and pyrazoline derivatives) against breast cancer cells before in vitro testing. Aims: To screen potential anticancer compounds of chalcone and pyrazoline derivatives through in silico approach. Methods: In this study were carried out multiple virtual screening steps to predict drug-likeness, pharmacokinetic, toxicity, and interactions between drug candidates and receptors involved cell in proliferation (EGFR, PDB.id 7LGS), angiogenesis (VEGFR1, PDB.id 3HNG; VEGFR2, PDB.id 4AG8), and oxidative stress (cytochrome P450, PDB.id 3UA1). Results: Results revealed that pyrazolines A, A1, A2, B, C2, D, and M could potentially be anticancer agents since the molecules qualify Lipinski’s rule, are predicted to have good pharmacokinetics, are indicated as harmless, and exhibit the best binding affinity based on molecular docking analysis. Conclusions: The EGFR appears to be the main pathway targeted by pyrazoline derivates. Meanwhile, the ligand will go through the VEGFR1, VEGFR2, or P450 pathways when it successfully overcomes the binding obstacle. In addition, pyrazolines A, A1, A2, B, C2, D, and M need to be synthesized and evaluated the in vitro and in vivo anticancer activity.
SCOPUS-BASED BIBLIOMETRIC ANALYSIS OF PUBLICATION ACTIVITY IN THE FIELD OF HEALTHY AGING IN 2013-2022
Authors: Kocyigit Burhan Fatih
Published: August 2023

Introduction: Life expectancy is getting longer, and the proportion of the elderly population is increasing. Therefore, the concept of healthy aging gains importance and attracts attention in the scientific community. This article presented a ten-year bibliometric analysis of articles on healthy aging in the Scopus database.
Methods: The Scopus database was used for the bibliometric analysis. The publication list was created using the keywords «aging well» and «healthy aging.» The number of articles, active countries-journals, frequent keywords, prolific authors, and funding sources were defined.
Results: An upward trend was observed in the number of articles related to healthy aging between 2013 and 2022. The five leading countries in publication activity were the United States, China, the United Kingdom, Germany, and Canada, respectively. The most prolific authors were Ferrucci, L., Franceschi, C., Evans, M.K., Bennett, D.A., and Deary, I.J. The five most active journals were Plos One, Scientific Reports, International Journal of Molecular Sciences, International Journal of Environmental Research and Public Health, and Frontiers in Aging Neuroscience.
Conclusion: Bibliometric analysis is a valuable method for assessing global trends in producing scientific literature on particular topics. This study revealed an upward trend in articles on healthy aging over time, indicating an increasing interest and focus on this topic. As the elderly population grows, it is anticipated that interest in healthy aging will progressively increase. It will be advantageous for researchers interested in this field to establish collaborations with prominent authors and institutions. Thus, they will canalize their future investigation in the proper direction.
COMPLEMENTARY THERAPIES FOR WOMEN WITH BODY IMAGE ISSUES
Authors: Usgu Serkan , Akıncı Büşra , Bali Kübra
Published: August 2023

Body image disorders involve dissatisfaction with a specific part or all of a woman’s body. A woman experiencing body image dissatisfaction may face psychological problems such as mood disorder, decreased self-esteem, and decreased physical activity. With the reflection of the weak-ideal woman’s appearance by society and mass media, women may be exposed to these problems and can internalize this by comparing their bodies with the idealized women’s bodies. Women may experience major hormonal changes due to pregnancy and menopause that affect their physical appearance, roles, and responsibilities in society and family, and breast and gynecological cancers. Alternative therapeutic methods for body image disorders are important for women. Physical activity and exercise, yoga, dance therapy, body awareness therapy, and manual therapy can all be recommended for women to improve body image.
In-vitro RESPONSE OF DIFFERENT FUNGICIDES AGAINST Mauginiella scaettae CAUSING DATE PALM INFLORESCENCE ROT IN TAFILALET OASIS IN MOROCCO
Authors: SANA OUAMEUR , TARIQ BOUHLALI EIMAD DINE , RACHID BOUAMRI , ADIL ESSARIOUI , REDA MEZIANI , ROKAYA HOUARI-KHAYRI , SAID AMIRI
Published: August 2023

The inflorescence rot is a very dangerous cryptogamic disease that is prevalent in all phoeniculture regions and causes heavy economic losses. The identification and characterization of the causal agent is a key step to tackling this disease, and such studies are very scanty in Morocco. This work was carried out in Darâa Tafilalet region South-East Morocco during 2020-2021 to isolate and identify the fungi that cause inflorescence rot on date palm and to try to combat the disease with various fungicides.  We collected 48 infected samples from different varieties of date palm. The isolation results revealed that Mauginiella scaettae is the primary causal agent of date palm inflorescence rot at all sites investigated. In terms of in vitro experiments, we examined seven fungicides (difenoconazole, boscalid-pyraclostrobin combination, thiophanate-methyl, copper oxychloride, tribasic copper sulfate, copper sulfate, and wettable sulfur) based on their antifungal activity against the causal agent, M. scaettae. Data on the effects of these fungicides on pathogen mycelial growth, spore germination, and sporulation show that difenoconazole, the combination Boscalid-Pyraclostrobin, and Thiophanate-methyl totally controlled M. scaettae at only 25% of the recommended dose, whereas Copper Oxychloride, Tribasic Copper Sulfate, and Copper Sulfate had a significant inhibitory effect on all three stages. Wettable sulfur was the least effective.
ALPHA TERPINENE ACTIVITY AS BIOINSECTICIDE ON RICE WEEVIL (Sitophilus oryzae L.) AND IT PROTEIN CONTENT
Authors: AFO OLUWATIMILEHIN , ONI MERCY , ADEBAYO RAPHEAL
Published: August 2023

An experiment was conducted to evaluate the toxicity of alpha terpinene on protein content and lipid peroxidation of rice weevil Sitophilus oryzae (L.) (Coleoptera: Curculionidae). The dried un-infested local rice used was obtained from a rice farm at Ilesa, Osun state, Nigeria. Bioassay was used to evaluate the effects of Alpha- terpinene on survival of Sitophilus oryzae. The efficacy of alpha- terpinene used on the antioxidant enzymes used on the S. oryzae, some of the biocidal efficacy of the compound on the activities of CAT, SOD, GPx, AChE, and GST was reported. Dosages of the treatment recorded above 40% mortality of the insect, except 10µl dosage of the compound that recorded 36.67% mortality of the insect. Only 50 µl dosage of the compound was able to record 100% mortality of the insect with 48 hrs treatment application and was significantly (p<0.05) different from other treatments. The negative coefficient of the compound indicated that the higher the dosage of the compound, the higher the mortality rate of the insect. Only 40 and 50 µl dosage of the compound effected 100% inhibition of the adult insect. The compound is significantly (p<0.05) different from the control. The research showed that the compound slowed the reactions in the insect which reduced. the activities and caused increase in mortality of the insect.
EFFECT OF BIOSTIMULATOR ON THE GROWTH, DEVELOPMENT AND YIELD OF AUTUMN WHEAT
Authors: YAQUBJONOVICH DJURYAEV MUQIMJON
Published: August 2023

The average yield of the experiments in the control variant was 64.3 s / ha, in the (standard) variant - 66.2 s / ha, in the variant using the bio stimulator the average yield was 66.8 s / ha, compared to the control variant - 2.5 s / ha. Additional yield was obtained. Observations showed that the bio stimulator was effective in the experimental variants when applied at the consumption rates given in the experimental scheme per hectare, ie an average of 2.5 quintals of additional yield was obtained from the control variant. Accelerated plant development phases allow for faster ripening of crops, early completion of harvests, and, of course, re-sowing of crops in vacant fields at convenient times. The increase in wheat yields indicates that better efficiency can be achieved through the use of bio stimulants. The economic performance of the winter wheat cluster and farms will improve.
USE OF RESOURCE-SAVING TECHNOLOGIES IN GROWING WINTER WHEAT
Authors: OBIDOVICH ABDURAKHMONOV SODIKJON
Published: August 2023

This article presents materials on the study of the need for winter wheat during the growing season to the norms of mineral fertilizers and the irrigation regime during the growing season with the additional use of various norms of bentonite clays for plowing in conditions of typical gray soils of the Tashkent region in 2008-2011. According to the results of the research, the introduction of 3000 kg/ha of bentonite clay under arable land and the irrigation of winter wheat during the growing season at a moisture content of 60–70–60% of the soil LFMC showed a decrease in the bulk density of soil in a layer of 0–30 cm by 0.03–0.05 g/cm3, and in layers of 30–50 cm on average up to 0.07 g/cm3, increasing soil water permeability by 30 m3/ha. At the same time, the irrigation rate decreased to 780–810 m3/ha compared to the control variant, and an additional grain yield of 11.9 centners/ha was obtained. Before sowing winter wheat, the introduction of 3000 kg/ha of bentonite clay under arable land and irrigation during the growing season at a moisture content of 70–80–70% of the soil LFMC, a decrease in the volumetric mass of soil in a layer of 0–30 cm by 0.07–0.08 g/cm3, and in layers of 30–50 cm, on average, up to 0.11 g/cm3, an increase in soil water permeability by 100 m3/ha, a decrease in the irrigation rate to 790 m3/ha compared to the control variant, and obtaining 13.4 c/ha of additional grain harvest.
BIOEFFICACY OF CHILLI PEPPER Capsicum frutescens (L.) AND IT’S INTERCROPPING ON THE GROWTH, YIELD AND INSECT PEST MANAGEMENT OF COWPEA Vigna unguiculata (L.) WALP IN THE RAIN FOREST AREA OF NIGERIA
Authors: H. O. ROSULU, , M. O. ONI, , T. I. OFUYA, , R. A. ADEBAYO,
Published: August 2023

The experiment was laid out in a 3x4 factorial experiment in randomized complete block design with 3 treatments (chilli pepper extract at 200 l/ha, 250 l/ha and local control) at 3 replications arranged as alternate intercropping, strip cropping, border cropping and sole cropping of cowpea with 12 plots and 60 ridges. The chilli pepper aqueous extract at 200 l/ha and 250 l/ha were sprayed on the cowpea plants at a spraying schedule of 10 am to 12 noon after insect sampling with the view of protecting it. Data were collected on growth parameters after planting, pest population and incidence of insects on cowpea, pod density, pod damage, grain yield, yield loss and phytotoxicity signs. Data collected were subjected to Analysis of Variance. The results indicated that 250 l/ha aqueous extract treated plots reduced the number of insect pests thrips (3.79±0.11), legume pod borer (1.76±0.24), legume pod borer nymph (1.17±0.06) and adult (1.07±0.05), and pod sucking bug adults (1.19±0.07) in intercropping situation, than 200 l/ha respectively, compared to untreated plots (1.31±0.09). There was significant difference (p < 0.05) between the treated plots (1.19±0.02) and untreated plots (1.46±0.02) in terms of pod damage as well as increased grain yields (0.12±0.00) when compared to the untreated control (0.07±0.00). In all, 250 l/ha causes higher phytotoxicity damage than 200 l/ha. The bio-pesticidal effect of chilli pepper on cowpea insects might not be unconnected with active ingredients present in it including glycosides, tannin, terpenoides, flavonoids, saponin, reducing sugar, steroids and resins. The study ranks 250 l/ha and alternate intercropping superior than other aqueous extract and cropping system respectively. However, alcoholic extracts of insecticides from C. frutescens may yield a more potent insecticide than ordinary aqueous extract. Extensive work will need to be done on the age of the sample after preparation and storage condition as this could affect the assessment of any plant material as a biopesticide.
FOOD CONTAMINATED WITH AFLATOXINS: CONSEQUENCES OF DIRECT AND INDIRECT CONSUMPTION
Authors: VILLA-MARTÍNEZ BEATRIZ GUADALUPE , PÉREZ-CRUZ CECILIA , DÍAZ-BARRITA AYMARA , MATÍAS-PÉREZ DIANA , SÁNCHEZ-MEDINA MARCO ANTONIO , PÉREZ-SANTIAGO ALMA DOLORES , GARCÍA-MONTALVO IVÁN ANTONIO
Published: August 2023

Research around the world relates the consumption of aflatoxins with liver cancer, however this is not the only condition that revolves around them, since it has been observed that many affectations, especially chronic aflatoxicosis, directly or indirectly, affects the health of populations, but mainly children and people with some other condition. In a general way we want to show in this work the scenario involved in the consumption of these mycotoxins and their effects produced by the adducts or products that intervene within the human body, as well as the types of biomarkers that can be used to know if there is exposure to these secondary metabolites and some chemoprotective drugs that are used to prevent further damage to the body. Concluding that more knowledge is needed to know a little more about the factors that involve the different affectations and how to reduce the risk.
SUPPRESSION OF IRRIGATION WATER DEFICIT STRESS AFFECTING SOYBEAN PRODUCTION
Authors: ELMAHDY SHIMAA M. , EL-SHERPINY M. A. , HELMY AMAL A.
Published: August 2023

Drought phenomena have been frequenting in Egyptian history. So, the drought in the agricultural sector is a particularly important area to be examined. Therefore, a field experiment was  carried out to  evaluate three irrigation intervals as main factor [irrigation every 7, 9 and 11 days], soil addition of some conditioners [ control ( without),  compost, zeolite and biochar ] as subplots and foliar application of  magnesium silicate (sprayed or not) as sub-subplots on the performance and productivity of soybean plants as well as soil fertility after harvest. The main results showed that the  soybean plants irrigated every 9 & 11 days had a low values of growth and  production criteria compared to the soybean plants irrigated every 7 days which had the highest values of  both growth criteria (e.g., plant height, fresh and dry weights and chlorophyll content) and yield components ( i.e., pod weight plant-1, seed weight plant-1, stover weight plant-1, 1000 seed weight, seed and stover yield). The  addition of all studied soil amendments improved all studied growth and production criteria compared to the corresponding soybean plants grown on  un amending soil, where the superior amendment was  compost followed by zeolite and lately biochar conditioner. On the other hand, foliar application of magnesium silicate improved all studied growth and production criteria compared to the corresponding soybean plants grown without foliar application. Also, all studied soil amendments differed among them in their positive effect on soil fertility as well as their vital role in saving irrigation water.