bluuebunny/crossref_metadata_2025 huggingface dataset:
THE NETWORK MODEL OF BUSINESS PROCESSES OF THE IT PROVIDER
Authors: Dobrynin Alexey Sergeyevich , Koynov Alexander Sergeyevich , Kulakov Stanislav Matveevich
Published: August 2017

The subject of the research is to improve the efficiency of business processes for various industries (for example, IT service provision). Constant involvement in the competition is forcing service providers and high-tech product manufacturers to optimize internal and external processes to achieve the desired result. The market information and other services need to obtain an integrated toolkit that allows to perform analysis of existing processes and their metrics and make management decisions. The paper focuses on variable procedural model or network model of the business process as one of the components of the assessment system and the possibility to improve the efficiency of enterprises and organizations. The main actively applied research methods are the system analysis of the elements of set theory and graph theory. Illustration of a business process model has been made with the assistance of a methodological framework of the best management practices in the IT sector. The following developing effective technologies of software systems have also been used: relational databases, object-oriented programming, and unit testing. The novelty of the research is to develop a changeable business process model, which if necessary can be adjusted for a particular subject area. The essence of the elements of the variable model is reflected in the possibility of a flexible dynamic binding of certain roles or assets to the processes of the network schedule or procedures. Thus, the proposed model is sufficiently versatile, which allows using it in a wide range of applications and systems for performance improvement with a comprehensive assessment of costs and resources.
RISK MANAGEMENT MODEL FOR DECISION SUPPORT IN THE FIELD OF FISHERIES
Authors: Aleksanyan Aleksanyan Igor Yuryevich , Kosmacheva Irina Mikhalovna , Maksimenko Yuriy Aleksandrovich , Sibikina Irina Vyacheslavovna , Khomenko Tat'iana Vladimirovna
Published: August 2017

The article deals with the mathematical model for choosing optimal strategy of behavior of the participants of managing fish products manufacturing. The model supposes recording and analyzing a great number of changing parameters, since management of activities in the field of fishery takes place in conditions of uncertainty (lacking in completeness orclarity of information, uncertainty related to the person making decision, his/her preferences and attitude to risk in the course of developing strategies of behavior in the industrial process) and availability of different risks (weather, anthropogenic, epidemiological, information, etc.). Selection rules were combined on the basis of various criteria convolutions in order to evaluate the usefulness of the solution. Optimal strategy selection helps to reduce economic losses. The results of the study are of applied nature and can be used in the development related to the design of information systems, as well as in the decision support systems for the fishing industry.
DEVELOPMENT OF THE CREATIVE COMPONENT OF THE EDUCATIONAL PROCESS IN THE TEACHING MATHEMATICAL DISCIPLINES USING ANALOGY METHOD
Authors: Efimov Pavel Vladimirovich , Karpasyuk Igor Vladimirovich
Published: August 2017

The article presents an overview of various methods for improving the quality of teaching and motivating learners. Features of the analogy method and the possibility of its application as an effective educational technology have been considered. The use of the analogy method in the educational process in the course of studying graph theory by students has been described. Cartesian graph is proposed as a method obtained with the help of analogy method for describing the graphs by the auxiliary function. The features of the Cartesian graph are studied and the basic laws are revealed, which enable to draw conclusions about the properties of a corresponding traditional graph. Two modifications of the Cartesian graph have been introduced, possessing a certain specific form of representation of the graph and thus helping to carry out more detailed investigation of it. Statements about some relationships between the characteristics of the traditional graph and the corresponding Cartesian graph with its modifications are proved. A computer program is described for modeling graphs in various forms of representation: in the form of a traditional diagram, a Cartesian graph, vertex and axial modifications of the Cartesian graph.
THE ROLE OF THE SIMULATION IN THE TECHNOLOGICAL DESIGN ANDPARAMETER ASSESSMENT OF CARGO TERMINALS
Authors: Goryntsev Mikhail Nikolaevich , Kuznetsov Alexander Lvovich , Pogodin Vladimir Alekseyevich , Shcherbakova-Slyusarenko Victoria Nikolaevna
Published: August 2017

The paper deals with the technologic design of cargo ports and terminals viewed as an example of a general fuctional design procedure. The goal of the functional design is in syntheses of the structure and parameters of an object enabling it to perform required key functions. In the context of the technologic design of cargo ports and terminals this task demands to provide justification of the structure and parameters of main tecnologic componets of the object: equipment, facilities, buildings, personal. The paper studies the official standrds and norms that impose a problem for the technologic design as an important part of the complex project. The problem is that the technologic design is excluded from the set of basic documents governing the structure and context of the resulting project documentation. On the other hand, actual norms of technologic design place a very strict reglamentation on every technologic sulution, in assumption that it would automatically provide the required complience with the demands for the final result of the design procedure. Such approach is found not only to bring off the results from the optimal solutions, but to put obstacles for using new progressive methods. Consequently, the cistomers develop the mistrust for the results of the design’s results, since they are interested in the final product and not in the procedure of its obtaining. The paper highlights this fact as the main reason why modern non-reglamentated methods are very poorely presented in the practice. In the same time, the modern spectrum of new mathematical tools, first to mention the object-oriented simulation, is very wide, and an exessive experience of the operation of the designed technolodical objects is accumulated. All these demand not for changing of the models used in the technologic design, but for the changing of the technologic design’s model, which is exactly the focus of this paper. Key words: functional design, simulation modelling, ports, terminals.
ASSESSMENT OF THE INFLUENCE OF THE SHIP SHAFT LINE FOOTINGS ARRANGEMENT ON ITS RIGIDITY
Authors: Kupryashin Ivan Aleksandrovich , Kushner Guriy , Mamontov Victor Andreevich , Khalyavkin Aleksey Aleksandrovich
Published: August 2017

The article focuses on the influence of the footing arrangement on the ship shaft line bending. It has been found that on board many modern ships actual length of shaft line tunnel is lowered, that is why revision of the constructive schemes of shaft lines for the purpose to lessen the number of shaft line footings is one of the important tasks. It should be noted that minimizing the footing number will lead to decreasing friction losses, weight of the propulsion unit, costs of the construction and labour intensiveness of assembling, as well as to improving flexibility of the shaft. The article presents the comparative analysis of the influence of number and position of footings on the beam bending. The results obtained provide grounds for the statement that at optimal positioning of footings their number can be decreased, which will result in preventing wear, shaft line and bearings jamming, and lessening resonance during ship operation.
Las primeras clasificaciones tripartitas de las partes de la oración: Villalón y el Brocense
Authors: Merrill Judith S.
Published: August 2017

En este número no se incluyeron resúmenes ni palabras clave.
Carlos Alberto Moreyra, Esoterismo religioso del Siglo de Oro español. Ed. del Autor, Córdoba (Argentina), 1965; 72 pp.
Authors: Soons Alan
Published: August 2017

Se reseñó el libro: Esoterismo religioso del Siglo de Oro español.
La ascendencia paterna de Juan Ruiz de Alarcón y Mendoza
Authors: King Willard F.
Published: August 2017

En este número no se incluyeron resúmenes ni palabras clave.
The Histoire of Araucana written in verse by Don Alonso de Ercilla translated out of the Spanishe into Englishe prose allmost to the ende of the 16: Canto. Ed., introd. y notas de Frank Pierce. Manchester University Press, Manchester, 1964; vii + xxi + 52 pp.
Authors: Amor y Vázquez José
Published: August 2017

Se reseñó el libro: The Historie of Araucana written in verse by Don Alonso de Ercilla translated out of the Spanishe into Englishe prose allmost to the Ende of the 16: Canto.
Joaquín Artiles, Los recursos literarios de Berceo. Gredos, Madrid, 1964; 269 pp. (BRH, Estudios y ensayos, 81).
Authors: Gariano C.
Published: August 2017

Se reseñó el libro: Los recursos literarios de Berceo.
Reducción de la vulnerabilidad sísmica en viviendas por desarrollo progresivo con mampostería no armada
Authors: Ramirez Héctor Saúl Quintana
Published: August 2017

Este artículo de reflexión relaciona los resultados obtenidos en investigaciones precedentes. Se reseña un estudio de casos de Viviendas por Desarrollo Progresivo (VPDP) en barrios populares de Bogotá, como también un diagnóstico del desempeño de sus sistemas constructivo y estructural en lo referente al cumplimiento de requisitos básicos de seguridad estructural y habitabilidad. En el trabajo se identificaron criterios normativos que regulan la reducción de la vulnerabilidad sísmica en construcciones existentes y en aquellas sujetas a restauración. Asimismo, se revisaron técnicas de atenuación de dicha vulnerabilidad, se evaluó su aplicabilidad a las VPDP de mampostería no armada y se identificaron las principales patologías que afectan la sismorresistencia de las edificaciones. La principal razón de la investigación ha sido disminuir la amenaza sísmica a que estas se encuentran expuestas debido a su precariedad, para satisfacer así las exigencias destinadas a salvaguardar la integridad de sus habitantes. En este sentido, al examinar entre el confinamiento de muros y el pañete armado cuál de las dos técnicas de intervención es más apropiada y replicable para reducir o mitigar las falencias de las VPDP, es posible mencionar que la segunda se evidencia potencialmente como la adecuada. Finalmente, se destaca la necesidad de evaluar ambos sistemas en sus aspectos técnicos, normativos y operativos para multiplicar su eficiencia y ampliar su cobertura.
El Paisaje de la Ruta Libertadora en Boyacá como Patrimonio cultural
Authors: Cordero Maria Leonor Mesa
Published: August 2017

En el presente artículo se revisa el tema del valor del paisaje como patrimonio cultural en el territorio comprendido por la Ruta Libertadora en Boyacá. La presentación comprende la aproximación a experiencias que han visto en el paisaje un patrimonio cultural mundial o local. Al considerar distintos lugares se tienen en cuenta los procesos de recuperación, salvaguardia o protección desarrollados mediante mecanismos o lineamientos potenciados por organismos como la Unesco y los Ministerios o entidades de cada país. En el caso colombiano, desde el Ministerio de Cultura se han definido políticas apoyadas en la ley que paulatinamente han avanzado en el cumplimiento de metas con el respaldo de los entes departamentales públicos y privados.  La revisión de experiencias confiere un panorama sobre la gestión llevada a cabo en el propósito de lograr el reconocimiento del paisaje en su dimensión de patrimonio cultural de las naciones. Tal valoración resulta pertinente en el proyecto que busca resignificar patrimonialmente la Ruta Libertadora, pues permitiría establecer una metodología facilitadora en la construcción de un modelo cuya aplicación conlleve a encontrar sentidos actuales a este contexto histórico, con base en un enfoque definido por el arraigo y la pertinencia.
El paisaje como organizador territorial. Metodología y práctica: paisaje de minifundio de Boyacá
Authors: García García Juan José
Published: August 2017

El paisaje ha sido visto siempre como una cuestión meramente estética, para deleite de los sentidos, en la cual prima su belleza por encima de otras cualidades. Desde hace unas décadas, dicho paradigma ha cambiado y se le ha visto también como un elemento que amalgama un territorio, poseedor de utilidad para la ordenación territorial y el desarrollo sostenible. Diferentes experiencias basadas en otras tantas metodologías se han aplicado para ponerlo como centro de dicha planificación. Con el método británico del análisis del paisaje por medio del carácter de sus elementos (Landscape Assessment Character), se logra una visión totalizadora que interrelaciona los elementos humanos y naturales, así como los históricos (pasados y actuales) con una mirada prospectiva orientada al desarrollo territorial y social, la protección medioambiental y la apropiación patrimonial. Este artículo centra su análisis en el departamento de Boyacá desde esa mirada metodológica, diferenciando su territorio en asociaciones de paisajes. El más representativo de estos, por su extensión e implicación social, es el minifundio o agrícola de subsistencia. Se examinan sus características, la valoración de estas y las propuestas para una gestión que lleve al desarrollo sostenible de la región.
Conexiones entre las infraestructuras de Louis I. Kahn y el diseño paramétrico
Authors: Jorge Camacho Cristina
Published: August 2017

Este artículo de reflexión es un análisis del artículo Toward a Plan for Midtown Philadelphia, publicado en 1953 por Louis I. Kahn en Perspecta 2, revista de la Universidad de Yale, para estudiar la forma de la ciudad en función de sus flujos a través de siete campos de investigación, con el objetivo de encontrar conexiones con los razonamientos actuales del diseño paramétrico. Independientemente de la planificación urbana, Kahn centra su atención en la velocidad de tráfico, definida como la distancia cubierta por unidad de tiempo, y estudia cómo unificar la etimología de los términos ‘translación’, ‘transferencia’, ‘movimiento’ y ‘metáfora’ mediante técnicas gráficas (los colores, el tamaño de las letras o los signos) e igualmente a través del estudio de la mecánica de fluidos. Utiliza el signo de la flecha para dar presencia a parámetros imposibles de percibir a simple vista a causa de la velocidad y desplaza el tema de la resistencia dedicada a los efectos que una corriente fluida ejerce sobre un cuerpo (un automóvil circulando dentro de un medio fluido, el aire), hacia el tema de la descarga que examina la distribución de los fluidos por tubos (una red de canales que desembocan en otro medio fluido, el agua). Kahn emplea herramientas específicas para analizar y simular la complejidad observada en la naturaleza y después la aplica en las formas estructurales de los edificios y en los patrones de organización urbana, en conexión con el diseño paramétrico cuya búsqueda formal intenta optimizar los objetivos de partida mediante ciertas restricciones en el diseño. Finalmente, en relación con la propuesta de Kahn, Aranda y Lasch publican el libro Tooling, de la serie Pamphlet Architecture, en el cual se incluye el proyecto 10 Miles Spiral, una infraestructura urbana en las Vegas que construye un servicio de descongestión del tráfico y un compacto centro comercial cuya forma helicoidal se generó con algoritmos y puede ser recorrido a 90 km/h. Ambos proyectos proponen nuevas vías de acercamiento a la forma fluida de la ciudad con propósitos sociales y con esta intención, el Plan for Midtown Philadelphia anticipó la visión del contexto como un medio continuo que desmaterializa la forma urbana y libera sus flujos.
Academia y política: El concepto de urbanismo detrás de la ley 388 de 1997
Authors: Ríos John Freddy Ramírez
Published: August 2017

Este artículo de reflexión derivado de investi- gación describe el conjunto de interacciones establecidas entre las esferas académica y política alrededor de la visión del urbanismo que encierra la vigente Ley 338 de 1997 de ordenamiento territorial en Colombia.Se describe el proceso de consolidación de dicha Ley en torno a su principio fundamental basado en el control público de la tenencia, el uso y la renta del suelo. Al final se pre- senta una interpretación de cómo tal proceso ha llevado a los especialistas locales en urbanismo a concentarse más en posicionarla políticamente que en fortalecerla académica y científicamente.
Educación en publicidad, un acercamiento al contexto colombiano
Authors: Pacheco Nancy Patricia García
Published: August 2017

Este artículo presenta una revisión bibliográfica sobre el tema específico de la publicidad. En primer término se han tenido en cuenta libros, artículos, revistas y normas que desarrollan el concepto, al igual que autores reconocidos -algunos en el contexto mundial y otros en el local- que han escrito al respecto en los últimos años. En esta búsqueda, el asunto más investigado se refiere a la definición del término publicidad, lo que lleva incluso a intentar esclarecer si se trata de un oficio o de una ciencia. En los trabajos que abordan la cuestión se encuentra un aspecto común muy ligado a la temática: la comunicación. Como segundo punto se construye una breve historia de la publicidad, vista desde la perspectiva de distintos expertos. Esta información permite mostrar lo que ha pasado recientemente en el campo teórico y en la industria publicitaria. El tercer tópico se refiere a la formación universitaria, a las carreras de publicidad actualmente existentes en el país y a sus currículos, fundamentales para el programa universitario, ya que dan cuerpo al objeto de estudio y son modelo que orienta el aprendizaje de la publicidad como vocación profesional.
Cementerio Muyahidín de Tetuán, estudio y propuesta sobre un paisaje patrimonial
Authors: Saga Manuel
Published: August 2017

En la investigación presentada en este artículo se trabajó sobre la ciudad de Tetuán, en el norte de Marruecos, y su principal cementerio musulmán, originado en el siglo XV. A través del análisis urbano del límite fortificado de la Medina de Tetuán, se desarrolló documentación cartográfica para comprender la estructura física y socioeconómica del área del cementerio como negativo urbano de la Medina. Sobre esta extensión se levantan los mausoleos de los Muyahidines (los fundadores nazaríes de la ciudad) que a pesar de su buena conservación material se encuentran actualmente amenazados por su mala preservación social. En respuesta a esta problemática, se elaboró un proyecto de investigación multiescalar (paisaje, ciudad y arquitectura) cuyos objetivos fueron establecer nuevos criterios para la gestión del tejido funerario, revitalizar su estructura social y conseguir la revalorización de su herencia histórica. Para ello, se estudiaron los modelos locales de gestión como herramienta para el desarrollo de soluciones sensibles con el carácter de este territorio, las cuales persiguen la construcción social del paisaje y encuentran en la identidad patrimonial su punto de partida.
Gestión de riesgos de colecciones. Dos casos de estudio en Tunja, Boyacá
Authors: Hernández Carlos Andrés Carreño
Published: August 2017

El presente artículo de reflexión derivada de Investigación relaciona los resultados obtenidos en dos investigaciones realizadas por el autor para la aplicación, por primera vez en Colombia, de la Metodología de Gestión de Riesgos en Colecciones (ICCROM-UNESCO 2009) en dos museos regionales: la Casa del Escribano Don Juan de Vargas (2011) y la Casa del Fundador Gonzalo Suárez Rendón (2013).  Se destaca la importancia de la metodología en cuestión para renovar la mirada de la ciencia de la conservación de colecciones en museos. Como punto de partida se toma el concepto de gestión de riesgos, para exponer luego los resultados a la luz de las fases metodológicas propuestas. De acuerdo con dichos resultados, se trata de dos entidades museales amenazadas tanto por agentes ambientales como antropogénicos que de no ser corregidos a tiempo atentan contra el sistema integral de valor custodiado. Se termina con una serie de conclusiones que giran en torno a la efectividad de la metodología implementada para los casos de aplicación, sus necesidades de adaptación al contexto local y la preocupante situación actual de la conservación de acervos museológicos en Colombia.
A novel variant of the GCDH gene causes glutaric aciduria type 1 in a Sudanese family: a case report
Authors: Ahmed Hamed Ahlam Abed Alrhman , Elseed Maha Abd El Moneim , Masoud Inaam Noureldyme Mohmed , Yararbas Kanay , Babiker Mohamed Osman Eltahir
Published: August 2017

Background:

Glutaric aciduria type 1 (GA1) is a rare autosomal recessive neurometabolic disorder caused by mutations in the glutaryl CoA dehydrogenase gene (GCDH). If left untreated, it leads to accumulation of neurotoxic metabolites leading to poor neurological outcomes characterized by encephalopathic crises, subdural effusions and extrapyramidal features.

Case presentation:

We hereby report a consanguineous Sudanese family in which the father and two children were affected whilst the mother was an asymptomatic carrier. All had a novel guanine insertion in position c.1173_1174 (c.1173dupG), resulting in a frame shift and a stop codon downstream (p.Asn392Glufs4X).

Conclusion:

To our knowledge, this GCDH variant has not been previously reported. Genetic testing should be made widely available in communities where consanguinity is prevalent. This will allow detection of new pathogenic gene variants.
Epidermodysplasia Verruciformis: a case report
Authors: Samia Sulaiman Alnugali
Published: August 2017

Background:

Epidermodysplasia verruciformis is a rare, inheritable disease characterized by an unusual susceptibility to infection with specific types of human papillomavirus and a greater propensity for developing malignant skin tumors.

Case presentation:

A 55-year old male was presented with complaint of painless, hard growth extending from his toe nail for the last one year. He was diagnosed as a case of Epidermodysplasia Verruciformis followed by Mohs surgical procedure.

Conclusion:

Epidermodysplasia Verruciformis is an autosomal recessive genetic disorder and it predisposes patients to widespread papilloma viral infection. This might be considered as a model of cutaneous human papilloma virus oncogenesis. Generally, Epidermodysplasia Verruciformis reveals an autosomal receding pattern of inheritance. Prolonged exposure to sunlight, living in high altitudes and outdoor occupations are the known risk factors to malignant deterioration of EV lesions.
The Inner Revolution: Shuddhi and the Reinvention of Hinduism
Authors: Mehta Nirav
Published: August 2017

The Shuddhi movement of the late 19th century was a religious revolutionary movement that aimed to intrinsically restructure and transform the Hinduism and Hindu society into a more socially equalized and religiously universal system. It was a quest to reconstruct Hindu religious and social identity in response to socioeconomic modernism and challenges from Christian and Islamic proselytization. The first phase of the movement lasted from the 1880s to the late 1910s and was defined by a persistent struggle with orthodox society to transform Hinduism by opening its doors to induct and assimilate returning and new converts. The second phase of Shuddhi began in the early 1920s with the emergence of a consensus between the orthodox and the Arya-led reformers, who expanded the Shuddhi movement to confront the challenges presented by Islam and Christianity; this phase ended in 1947.
O lúdico e a afroidentificação na poesia: entrevista com o poeta afro-brasileiro Marcos Fabrício Lopes da Silva
Authors: Souza Gustavo Tanus Cesário de
Published: August 2017

Entrevista com o poeta Marcos Fabrício Lopes da Silva, concedida a Gustavo Tanus, em 13/07/2016. ---DOI: http://dx.doi.org/10.25094/rtp.2017n23a346
Entre golpes, revoltas e regressos: imagens e miragens do Chile na obra de Ferreira Gullar
Authors: Ferraz de Paula Marcelo
Published: August 2017

Este artigo propõe a leitura de algumas referências ao Chile na obra de Ferreira Gullar. Para tanto, desenvolve uma análise de “Dois poemas chilenos”, “Queda de Allende” e “Volta a Santiago do Chile”, publicados respectivamente em Dentro da noite veloz (1974), Muitas Vozes (1999) e Em alguma parte alguma (2010). Defendemos que estes poemas que abordam explicitamente os seus anos de exílio no Chile ocupam posições estratégicas na obra do autor maranhense. O seu exame indica uma complexa reordenação de lembranças e traumas ligados à frustração de certas alternativas históricas, permitindo acompanhar importantes mudanças em sua poesia, bem como a sua tensa articulação com a história política da América Latina.---DOI: http://dx.doi.org/10.25094/rtp.2017n23a422
Expressionismo e reificação: o corpo como espaço de resistência em “O homem inacabado” de Donizete Galvão
Authors: Andrade Rangel Gomes , Vicente Adalberto Luis
Published: August 2017

Em O Homem Inacabado (2010), o poeta Donizete Galvão compõe uma obra na qual uma das linhas de força é o corpo. Tema recorrente na poesia brasileira contemporânea, este surge em Galvão numa chave que articula deficiência e velhice, em que a realidade opressora da metrópole e do trabalho revelam a inadequação de sujeitos anônimos de corpos cindidos, mutilados ou reificados. Essas imagens do corpo são trabalhadas através de recursos hiperbólicos e deformantes que aproximam Donizete Galvão da estética Expressionista. Nesse processo, Galvão canta a inadequação (e resistência) do corpo deficiente e obsoleto a um mundo cada vez mais utilitarista.---DOI: http://dx.doi.org/10.25094/rtp.2017n23a423
A VIOLAÇÃO DOS DIREITOS FUNDAMENTAIS NA HORA DO PARTO: UMA ANÁLISE DA AUTONOMIA E EMPODERAMENTO DA MULHER
Authors: Correa de Barros Bruno Mello , Ruviaro Rianne , Richter Daniela
Published: August 2017

Tendo em vista a crescente discussão acerca da violência de gênero na sociedade, constatou-se a necessidade de um aprofundamento no tema relativo aos direitos fundamentais da mulher desrespeitados na hora do parto no caso de violência obstétrica e a sua relação com o empoderamento e autonomia da mulher. O presente artigo, pretende analisar toda a problemática dos procedimentos médicos invasivos e desatualizados sem a real indicação no momento do parto que ferem o poder de autonomia da mulher e como é possível evitar esse ferimento. Especificamente, projeta realizar uma análise histórica da evolução do parto, a institucionalização do mesmo e a consequente medicalização do corpo da mulher. Além disso, propõe-se constatar a correlação da violência obstétrica e da violação dos direitos fundamentais da mulher. Também programa analisar o parto humanizado como uma possível solução ao não ferimento da autonomia da mulher, em conjunto com a necessidade de políticas públicas para sua concretização, com o intuito de tratar a mulher com mais humanidade. Para tanto, utiliza-se o método de abordagem dedutivo e método de procedimento monográfico.
Effect of Sonication, Liquid Nitrogen Cooling During Crystal Growth and Heating Process on Crystal Growth of Paclitaxel Coated on a FullyBioabsorbable Poly (L-Lactic acid) Stent
Authors: Yamada Hirokazu , Kinoshita Mitsuhiko , Yagi Shinichi , Matsubara Chisa , Igaki Keiji , Yamane Hideki
Published: August 2017

To achieve appropriate efficacy of paclitaxel (PTX) used in drug eluting stents, uniform PTX coating on the stent and increased initial release of PTX leading to immediate therapeutic level of the drug are required. The present study investigated whether either restriction
of crystal growth though sonication and subsequent liquid nitrogen cooling, or formation of anhydrous PTX crystals through heating
microcrystals after seeding and crystal growth could increase PTX initial release coated on a fully-bioabsorbable poly(L-lactic acid) stent.
The sonication and subsequent liquid nitrogen cooling of the growing PTX crystals could prevent stable attachment of the crystals onto
the stent surface. In addition, the initial PTX release from the stent applied sonication during the crystal growth process followed by
heating showed five times as high as the stent without heating, which indicated the heating improved the PTX release from the stent at
early phase. These results suggested that PTX was changed into an anhydrous soluble form.
Effect of Vial shaking on Loading Time of Epirubicin into Drug-Eluting Bead
Authors: Ikeda Kenji , Kawamura Yusuke , Kobayashi Masahiro , Fukushima Taito , Sorin Yushi , Kunimoto MHideo , Hosak Tetsuyaa , Saitoh Satoshi , Sezaki Hitomi , Akuta Norio , Suzuki Fumitaka , Suzuki Yoshiyuki , Arase Yasuji , Kumada Hiromitsu
Published: August 2017

Background: Although DC Bead has been useful in treatment of multiple and large hepatocellular carcinoma, loading
time of doxorubicin into the DC Bead takes a long time of 30-120 minutes. Epirubicin is also used as an antitumor agent
together with DC Bead, but its loading efficiency was not sufficiently elucidated. Methods: To shorten loading time of
epirubicin into DC Bead (100-300µm, 300-500µm, 500-700µm), we examined the following three methods after mixing
the drug: (a) let stand in room temperature, (b) agitated for 30 seconds with Vortex mixer, and (c) sonicated for 30
seconds with ultrasonic cleaner. After loading of epirubicin by each method, supernatant concentration for epirubicin was
assayed at 5, 10, 30, 60, and 120 minutes. Results: Epirubicin loading rates for small bead (100-300µm) at 5 minutes
were 82.9 % in group a, 93.8% in group b, and 79.9 % in group c. Similarly, medium bead (300-500µm), 40.1% in group
a, 65.7% in group b and 45.5% in group c, respectively. In large-sized bead (500-700µm), loaded rates of epirubicin were
38.8% in group a, 59.0% in group b and 48.0% in group c. Agitation of mixture of epirubicin and DC Bead with Vortex
mixer significantly shortened the loading time, but sonication did not affect the time required. Microscopic examination
did not lead to any morphological change of microspheres in all the methods. Conclusions: Short time of agitation with
Vortex mixer reduced the necessary time for loading of epirubicin in every standard of DC Bead.
A Systemic Review on Ophthalmic Hydrogel in Contact Lenses
Authors: Insan Kurniawansyah , Soraya Mita
Published: August 2017

There has been a recent advances in the field of microbiology where hydrogels contact lenses can be extend as the new
ophthalmic drug delivery. Rather than the conventional eye drops, these hydrogels can minimize the side effect also
prolonged the residence time of drug. Hydrogels are three-dimensional, hydrophilic, and polymeric networks capable of
absorbing great volume of water and biological fluid. Hydrogel becomes the leading material for contact lenses because
its biocompatibility and transparent characteristic. The purpose of this article is to review on few types of ophthalmic
hydrogel in contact lenses and its application.
Biocompatibility of Silver Nano Bio-conjugates from Vitis vinifera Seeds and its Major Component Resveratrol
Authors: Preethi R. , Padma P.
Published: August 2017

The study focused on the green synthesis of silver nanobioconjugates (AgNPs) from phenolic-rich fruit source, Vitis
vinifera seed extract and its major component phenolic, resveratrol respectively. Sunlight exposure for 20 minutes was the
method of choice for the synthesis of AgNPs of the extract as well as the phenolic, resveratrol. The synthesized
nanobioconjugates were characterized using UV-Visible spectroscopy, Transmission electron microscopy (TEM), Energy
dispersive X-ray analysis (EDAX), X-ray diffraction (XRD), Polydispersity index, Zeta potential and Fourier transform
infrared spectroscopy (FTIR). The reduction of silver ions was confirmed by UV-visible spectroscopy with peaks at 440nm
for both nanobioconjugates synthesized from seed extract and compound. The nanobioconjugates showed the spherical in
shape with 14-35nm in size and crystalline in nature. The conjugates are well dispersed with 0.301 and 0.287 polydispersity
index and the zeta potential range at -13.6 and -14.3mV for stability. The FTRI data proved that the components in grape
seeds act as good reductants and stabilizers for the silver nanobioconjugate synthesis. All the synthesized
nanobioconjugates exhibited steady and sustained release of the medicinal components conjugated, proving their
druggability, and were biocompatible with human cells, demonstrating their safety. The findings of the study validate the
anticancer properties of silver nanobioconjugates of Vitis vinifera and its active component resveratrol.
Hubungan Pola Asuh Orangtua Terhadap Pertumbuhan dan Perkembangan Anak dengan Autism
Authors: Migang Yena Wineini
Published: August 2017

Hubungan Pola Asuh Orangtua Terhadap Pertumbuhan dan Perkembangan Anak dengan Autism

Abstrak

Latar belakang: Autism adalah kelainan perkembangan sistem saraf pada seseorang yang kebanyakan diakibatkan oleh faktor hereditas dan kadang-kadang telah dapat dideteksi sejak bayi berusia 6 bulan. Pola asuh orangtua juga sangat dibutuhkan dalam tahap pertumbuhan dan perkembangan, karena waktu terbanyak interaksi anak autis ada dalam keluarga. Orangtua berperan sebagai stimulator pertumbuhan dan perkembangan anak autis.

Metode: Desain penelitian cross sectional, dengan uji bivariat dengan Spearman rho. jumlah sampel 84 anak autism dan orangtua mereka di Kota Palangka Raya, pengambilan sampel dengan tehnik sampling purposive, pengambilan data menggunakan lembar observasi, kuesioner dan software Anthro WHO Plus 2011.

Hasil: Pola asuh orangtua yang tertinggi,  pola asuh demokratis (84,5%), pola asuh permisif (8,3%), pola asuh ototriter (7,1 %). Status gizi pada anak autism persentase tertinggi adalah status gizi normal (53,6%), status gizi gemuk (21,4%), status gizi obesitas (17,9%), status gizi kurus dan sangat kurus masing-masing sama (3,6%). Tingkat Kognitif anak autism, persentase tertinggi tingkat kognitifnya meningkat (73,8%), dan tingkat kognitif tetap (26,2%). Ada hubungan signifikan anatara pola asuh orangtua dengan status gizi anak autism, dimana nilai ρ 0,008 > α 0,01. Ada hubungan signifakan antara pola asuh ibu dengan tingkat kognitif anak autism ρ 0,001 > α 0,01.

Kesimpulan: Perlu diteliti lagi faktor lainnya yang menyebabkan status gizi anak autis dapat menjadi obesitas bahkan ada yang sangat kurus, sehingga walaupun anak autism harus diet glutein dan casein, sebagai syarat awal terapi anak autis, mereka tetap dapat memiliki status gizi normal, serta tidak mengalami obesitas akibat komposisi makanan yang tidak diperhatikan. Orangtua perlu menentukan pola asuh yang tepat sebagai media interaksi yang dengan anak autis, karena anak autism yang mengalami hambatan berkomunikasi akan sulit untuk menerima informasi dari lingungan, yang artinya akan sulit untuk meningkat kognitifnya dalam proses belajar dan akan sulit pula menerima pengaturan diet sebagai non medikamentosa terapi anak autis.

Kata kunci: Pola asuh orangtua, kognitif, status gizi, anak autism
KOHERENSI ANTARKALIMAT PADA PARAGRAF DALAM WACANA ILMIAH BAHASA JAWA (Coherence Between Sentences on Paragraph in Javanese Language Scientific Discourse)
Authors: Sumadi NFN
Published: August 2017

This research discusses about various kinds of coherence between sentences in Javanese language scientific discourse. Qualitative descriptive method is used in this research due to objectives of the research that is to provide kinds of coherence between sentences in the Javanese language scientific discourse. The sentence coherence in Javanese scientific discourse paragraph can be differentiated as (1) causality, (2) analysis (partial analysis, functional analysis, process analysis), (3) opposition, (4) validation, (5) continuity, (6) addition, (7) sequence, and (8) explanation. Any kind of coherence can be signified with cohesion, which is not only originated from the Javanese language, but also can be absorbed from Indonesia language or not signified.
The Mak Yong Dance Theatre as Spiritual Heritage: Some Insights
Authors: Yousof Ghulam-Sarwar
Published: August 2017

Mak yong is an ancient dance-theatre form incorporating the elements of ritual, stylized dance and acting, vocal and instrumental music, song, story, and formal as well as improvised spoken text. It is principally performed in the two provinces of Patani in southern Thailand and Kelantan in Malaysia on the east coast of the Malay Peninsula, as well as, to some extent, in the Riau Islands of Indonesia. On the peninsula, mak yong was also active in the state of Kedah at one time. Mak yong troupes from the Malay Peninsula are known to have travelled to northern Sumatra in Indonesia, where they received some royal support in the province of Deli, while in the Riau Islands of Indonesia occasional performances are still staged.This paper was presented as the keynote address at the Mak Yong Spiritual Dance Heritage: Seminar and Performances, organized by SEAMEO SPAFA in collaboration with the Thai Khadi Research Institute, Thammasat University, on 20-21 September 2011 at Thammasat University, Bangkok. It is part of an upcoming collected edition of papers presented at the seminar.
Ajarn Chin You-di – a brief tribute
Authors: Glover Ian Carvel
Published: August 2017

My presentation is simply to acknowledge the help and encouragement of Ajarn Chin You-di to myself and teams of British and Thai archaeologists to resume the excavation of the important Iron Age, late-prehistoric site at Ban Don Ta Phet in Phanom Tuan District of Kanchanaburi Province which Ajarn Chin had undertaken in 1976. Ban Don Ta Phet is one of the earliest, if not the earliest site in Thailand to show clear connections with the early Buddhist civilizations of India in the last few centuries BCE. Research on the excavated finds has led to numerous dissertations and academic publications by Thai, British and international students and colleagues over the past forty years and have contributed to three Ph D theses, five Masters dissertations, two BA/BSc reports and thirty-two journal or conference publications.
Rituals of Cầu mùa (Praying for a Fertile Crop) in Vietnam: Similarity in Concept and Diversity in Practice
Authors: Pham Chung Thuy Thi
Published: August 2017

Similar to many Southeast Asian cultures, Vietnam has drawn its cultural identity from agriculture, particularly the rice culture. The rituals of Cầu mùa (Praying for a Fertile Crop) are present in the cultures of most of the peoples residing in Vietnam, from the highlands in the central area to the northern mountains. In Vietnam, the rituals of Cầu mùa are usually held in spring, the season for breaking ground and sowing, when farmers have a common wish for a fertile and bumper crop. However, ritual practice varies due to the diversity of environmental conditions, customs and the experiences of different communities. This article is a study of the similarity in concept and diversity in practice of the Cầu mùa rituals in Vietnam.This paper was presented at the Spiritual Dimensions of Rice Culture in Southeast Asia: Seminar, Rituals and Performances, organized by SEAMEO SPAFA on 11-14 May 2015 at Srinakharinwirot University, Bangkok, Thailand. It is part of an upcoming collected edition of papers presented at the seminar.
The epitrigeminal approach to the brainstem
Authors: Zenonos Georgios Andrea , Fernandes-Cabral David , Nunez Maximiliano , Lieber Stefan , Fernandez-Miranda Juan Carlos , Friedlander Robert Max
Published: August 2017

OBJECTIVE

Surgical approaches to the ventrolateral pons pose a significant challenge. In this report, the authors describe a safe entry zone to the brainstem located just above the trigeminal entry zone which they refer to as the “epitrigeminal entry zone.”

METHODS

The approach is presented in the context of an illustrative case of a cavernous malformation and is compared with the other commonly described approaches to the ventrolateral pons. The anatomical nuances were analyzed in detail with the aid of surgical images and video, anatomical dissections, and high-definition fiber tractography (HDFT). In addition, using the HDFT maps obtained in 77 normal subjects (154 sides), the authors performed a detailed anatomical study of the surgically relevant distances between the trigeminal entry zone and the corticospinal tracts.

RESULTS

The patient treated with this approach had a complete resection of his cavernous malformation, and improvement of his symptoms. With regard to the HDFT anatomical study, the average direct distance of the corticospinal tracts from the trigeminal entry zone was 12.6 mm (range 8.7–17 mm). The average vertical distance was 3.6 mm (range −2.3 to 8.7 mm). The mean distances did not differ significantly from side to side, or across any of the groups studied (right-handed, left-handed, and ambidextrous).

CONCLUSIONS

The epitrigeminal entry zone to the brainstem appears to be safe and effective for treating intrinsic ventrolateral pontine pathological entities. A possible advantage of this approach is increased versatility in the rostrocaudal axis, providing access both above and below the trigeminal nerve. Familiarity with the subtemporal transtentorial approach, and the reliable surgical landmark of the trigeminal entry zone, should make this a straightforward approach.
Treatment of aneurysms in patients with moyamoya disease: a 10-year single-center experience
Authors: Ni Wei , Jiang Hanqiang , Xu Bin , Lei Yu , Yang Heng , Su Jiabin , Gu Yuxiang , Mao Ying
Published: August 2017

OBJECTIVE

Moyamoya disease (MMD) is occasionally accompanied by intracranial aneurysms. The purpose of this study was to delineate the efficacy of the authors’ current surgical strategy in the management of MMD-associated aneurysms of different types.

METHODS

Between January 2007 and March 2016, a consecutive cohort of 34 patients with 36 MMD-associated aneurysms was enrolled in this prospective single-center cohort study. The lesions were classified as peripheral (17 aneurysms) or main trunk aneurysms (13 in the anterior circulation and 6 in the posterior circulation). For the peripheral aneurysms, revascularization with or without endovascular treatment was suggested. For the main trunk aneurysms, revascularization alone, revascularization with aneurysm clipping, or revascularization with aneurysm embolization were used, depending on the location of the aneurysms.

RESULTS

Of the peripheral aneurysms, 4 were treated endovascularly with staged revascularization, and 13 were treated solely with cerebral revascularization. Of the 13 main trunk aneurysms in the anterior circulation, 10 were clipped followed by revascularization, and 3 were coiled followed by staged cerebral revascularization. Of the 6 main trunk aneurysms in the posterior circulation, 4 underwent endovascular coiling and 2 were treated solely with revascularization. One patient died of contralateral intracerebral hemorrhage 6 months after the operation. No other patients suffered recurrent intracranial hemorrhage, cerebral ischemia, or aneurysm rupture. An angiographic follow-up study showed that all the bypass grafts were patent. Complete occlusion was achieved in all 21 aneurysms that were clipped or embolized. Of the remaining 15 aneurysms that were not directly treated, 12 of 13 peripheral aneurysms were obliterated during the follow-up, whereas 1 remained stable; 1 of 2 posterior main trunk aneurysms remained stable, and the other became smaller.

CONCLUSIONS

The authors’ current treatment strategy may benefit patients with MMD-associated aneurysms.
Transient resolution of venous sinus stenosis after high-volume lumbar puncture in a patient with idiopathic intracranial hypertension
Authors: Buell Thomas J. , Raper Daniel M. S. , Pomeraniec I. Jonathan , Ding Dale , Chen Ching-Jen , Taylor Davis G. , Liu Kenneth C.
Published: August 2017

Stenosis of the transverse sinus (TS) and sigmoid sinus (SS), with a trans-stenosis pressure gradient, has been implicated in the pathophysiology of idiopathic intracranial hypertension (IIH). MRI has shown improvement in TS and SS stenosis after high-volume lumbar puncture (HVLP) in a subset of patients with IIH. The authors present the first report of an IIH patient with immediate post-HVLP TS and SS trans-stenosis pressure gradient reduction and an attendant increase in TS and SS cross-sectional area confirmed using intravascular ultrasonography (IVUS). Recurrence of the patient’s TS-SS stenosis coincided with elevated HVLP opening pressure, and venous sinus stent placement resulted in clinical improvement. This report suggests that TS and SS stenosis may be a downstream effect of elevated intracranial pressure in IIH, rather than its principal etiological mechanism. However, the authors hypothesize that endovascular stenting may obliterate a positive feedback loop involving trans-stenosis pressure gradients, and still benefit appropriately selected patients.
One hundred consecutive endoscopic repairs of sagittal craniosynostosis: an evolution in care
Authors: Nguyen Dennis C. , Farber Scott J. , Skolnick Gary B. , Naidoo Sybill D. , Smyth Matthew D. , Kane Alex A. , Patel Kamlesh B. , Woo Albert S.
Published: August 2017

OBJECTIVE

Endoscope-assisted repair of sagittal craniosynostosis was adopted at St. Louis Children’s Hospital in 2006. This study examines the first 100 cases and reviews the outcomes and evolution of patient care protocols at our institution.

METHODS

The authors performed a retrospective chart review of the first 100 consecutive endoscopic repairs of sagittal craniosynostosis between 2006 and 2014. The data associated with length of hospital stay, blood loss, transfusion rates, operative times, cephalic indices (CIs), complications, and cranial remolding orthosis were reviewed. Measurements were taken from available preoperative and 1-year postoperative 3D reconstructed CT scans.

RESULTS

The patients’ mean age at surgery was 3.3 ± 1.1 months. Of the 100 patients, 30 were female and 70 were male. The following perioperative data were noted. The mean operative time (± SD) was 77.1 ± 22.2 minutes, the mean estimated blood loss was 34.0 ± 34.8 ml, and the mean length of stay was 1.1 ± 0.4 days; 9% of patients required transfusions; and the mean pre- and postoperative CI values were 69.1 ± 3.8 and 77.7 ± 4.2, respectively. Conversion to open technique was required in 1 case due to presence of a large emissary vein that was difficult to control endoscopically. The mean duration of helmet therapy was 8.0 ± 2.9 months. Parietal osteotomies were eventually excluded from the procedure.

CONCLUSIONS

The clinical outcomes and improvements in CI seen in our population are similar to those seen at other high-volume centers. Since the inception of endoscope-assisted repair at our institution, the patient care protocol has undergone several significant changes. We have been able to remove less cranium using our “narrow-vertex” suturectomy technique without affecting patient safety or outcome. Patient compliance with helmet therapy and collaborative care with the orthotists remain the most essential aspects of a successful outcome.