bluuebunny/crossref_metadata_2025 huggingface dataset:
The Neoliberal Subject of Value
Authors: van Doorn Niels
Published: December 2014

In this essay, I introduce the figure of the “neoliberal subject of value” to explore the affective ambiguities of what Tiziana Terranova has termed “free labor,” or the voluntary, unwaged, and exploited activities that generate the digital data, content, and connections central to informational capitalism. If, as Terranova argues, free labor is characterized by exhaustion—due to the lack of means by which this labor can sustain itself—why are millions of people still sustaining a commitment to such pervasive modes of unremunerated work? To formulate an answer to this question, I first turn to the neoliberal theory of human capital, which offers a more fruitful avenue for the analysis of digitally mediated “living labor” than the Autonomist Marxist theory that inspired Terranova’s analysis, by elucidating how a logic based on competition, entrepreneurialism, and speculation has transformed how work is understood and valued. Second, I discuss the central role of commensuration within capitalist value production, arguing that human capital functions as a “commensurating machine” that allows neoliberal governmentality to permeate areas of life previously impervious to market rationality. Third, I show how such practices of market commensuration depend on a range of evaluative devices that create environments of equivalence and hierarchical difference, explicating how these devices have come to play an increasingly important role in contemporary digital culture. I then discuss a case study of Klout, a digital device that commensurates variegated social data into a score that ranks users according to their “influence,” which has become an important, if contentious, measure of human capital in information economies. Finally, I return to the neoliberal subject of value and her affective ambiguities, which index both the aspirations and exhaustion of competitive value-generating sociality.
Using an Ionic Liquid as the Porogen in the Preparation of Methacrylate-Based Monolith in Capillary Liquid Chromatography
Authors: Na Chen , Jun Chen , Kun-Feng Liu , Lian-Yang Bai , Yu-Ping Zhang
Published: December 2014

A methacrylate monolith was prepared inside a fused silica capillary column by microwave irradiation using an ionic liquid (1-hexyl-3-methylimidazolium tetrafluoroborate) as the porogenic solvent. Baseline separation of the model analytes, including thiourea, benzene, toluene, ethylbenzene and propylbenzene, was achieved by capillary liquid chromatography, with the lowest theoretical plate height of 26.83 µm for benzene. In addition, we also investigated the effects of the acetonitrile content in the mobile phase, flow rate on retention time, resolution and total porosity. The morphology of methacrylate monolith was studied by scanning electron microscopy.
Experimental and Analytical Studies on a Reinforced Concrete Frame Retrofitted with Buckling-Restrained Brace and Steel Caging
Authors: Zhang Jiaguang , Wu Bin , Mei Yang , Shing P. Benson
Published: December 2014

A hybrid seismic retrofit scheme, which utilizes a buckling-restrained brace (BRB) to enhance the lateral strength, stiffness and energy dissipation capacity of a seismically-weak reinforced concrete (RC) frame and steel caging to improve the flexural and shear strength of the deficient RC columns and beam-column joints, is proposed. Cyclic quasi-static tests were performed on two half-scale one-story, and single-bay RC frames to evaluate the efficiency of the hybrid retrofit technique. The performance of the BRB, the steel caging, and the connections of the retrofitted frame were studied and found to be satisfactory. The BRB significantly increased the lateral load resistance and energy dissipation capacity of the frame, and the steel caging could effectively change failure mechanism of the RC frame by preventing column failure. Analytical models were developed with OpenSees to simulate the experimentally observed behaviors. Reasonable agreements were achieved between the numerical and experimental results.
New Failure Criterion to Determine the Load Carrying Capacity of Two-Way Reinforced Concrete Slabs
Authors: Wang Yong , Dong Yu-Li , Yuan Guang-Lin , Zou Chao-Ying
Published: December 2014

This paper presents a modified theoretical model for determining the load carrying capacity of reinforced concrete slabs. Based on the force and moment equilibrium requirement at the yield-line section, a new stress failure criterion was established to explain the failure mode of crushing of concrete. The effectiveness of the present model was validated through satisfactory comparison with results from experiments and other theoretical simulations. Unlike the previous studies, the model can reasonably interpret why for the similar reinforcement the square slabs always fail at a lower vertical displacement compared with the rectangular slabs.
Repair and FRP Strengthening of Earthquake-Damaged RC Shallow Beam-Column Joints
Authors: Elsouri Amer M. , Harajli Mohamed H.
Published: December 2014

Three earthquake-resistant wide beam-column joint specimens (one interior, and two exterior) which developed beam plastic hinging mechanism and beam flexural failure under large drift reversals were repaired and FRP strengthened for restoring their structural function. The repair and strengthening technique consisted of: (i) sealing the major flexural cracks that developed within the beam plastic hinge region using epoxy injection; (ii) adding carbon fiber-reinforced polymer (CFRP) reinforcement at the top and bottom faces of the beam to control the growth of the flexural cracks, boost up the beam negative and positive flexural capacities and at the same time compensate in part for the loss in the joint lateral stiffness; and (iii) providing CFRP jacket at the potential hinging regions of the columns for confining the concrete and enhancing the bond capacity of the spliced reinforcement. The effectiveness of the upgrading technique is demonstrated by comparing the performance of the upgraded joints when subjected to lateral cyclic loading against the performance of the same joints before damage. With its simplicity in application, the upgrading technique succeeded in bringing the damaged joints back into service conditions and in restoring their flexural stiffness under lateral load which degraded due to large drift reversals.
Numerical and Experimental Investigation on Eccentric Loading Behavior of RC Columns Strengthened with SCC Filled Square Steel Tubes
Authors: Lu Yi-Yan , Liang Hong-Jun , Li Shan , Li Na
Published: December 2014

Self-compacting Concrete Filled Square steel Tubes (SCFST) is used to strengthen square RC columns. In order to investigate the eccentric loading behavior of the strengthened columns, a generic fiber element model is proposed. The ultimate strengths and the complete load-deflection response at the mid-height of the strengthened columns are predicted by the model in the aid of computational procedure. To verify the accuracy of the computational results, related experiments have been performed. The obtained experimental results were then compared with the computational results. After finding close agreement between them, the effects of extensive experimental parameters on the behavior of strengthened columns are investigated, including tube wall thickness, concrete compressive strength and initial eccentricity. Furthermore, a simple design formula based on the verified model is proposed to calculate the ultimate strength of eccentrically compressed strengthened columns. The calculation results agree well with the experimental results.
How Coaches Use Strongman Implements in Strength and Conditioning Practice
Authors: Winwood Paul W. , Cronin John B. , Keogh Justin W.L. , Dudson Mike K. , Gill Nicholas D.
Published: December 2014

This article describes how strongman implements, which we defined as “any non-traditional implement integrated into strength and conditioning practice” are currently utilised by coaches to enhance athletic performance. Coaches (mean ±SD 34.0 ±8.2 y old, 9.8 ±6.7 y general strength and conditioning coaching experience) completed a self-reported 4-page survey. The subject group included coaches of amateur (n = 74), semi-professional (n = 38) and professional (n = 108) athletes. Eighty-eight percent (n = 193) of coaches reported using strongman implements in the training of their athletes. Coaches ranked sleds, ropes, kettlebells, tyres, sandbags and farmers walk bars as the top six implements used, and anaerobic/metabolic conditioning, explosive strength/power and muscle endurance as the three main physiological reasons for its use. The strongman implements were typically used in combination with traditional exercises in a gymnasium-based setting. Future research needs to evaluate the performance benefits of such training practices in controlled studies.
Association between Leg Power and Sprinting Technique with 20-m Sprint Performance in Elite Junior Australian Football Players
Authors: Young Warren , Grace Steve , Talpey Scott
Published: December 2014

The main purpose of this study was to determine the association between leg power and sprint technique with 20-m sprint performance. Seventy-seven elite junior Australian Rules football players were assessed on a 20-m sprint test, a countermovement jump (CMJ) and a two bound test, and on a new method of quantifying sprint technique from simple video recordings. Technique assessment involved rating 14 points on a scale from 1–5. Players were median-split into faster and slower groups based on their 20-m times, and they were compared for differences in leg power and technique. The faster group was significantly better (p<0.05) in the two-bound test (5.2%) and the technique score (8.2%), but not in the CMJ (p>0.05). A multiple regression indicated that the two-bound test and technique accounted for 37.7% of the variance associated with the 20-m sprint time (p<0.05). It was concluded that the technique assessment tool captured some important characteristics of 20-m sprint performance and could potentially be used to profile or monitor athletes. Further the two-bound test is a more relevant test for developing athletes because of its specificity to sprinting, compared to the CMJ.
Standardisation of Acceleration Zones in Professional Field Sport Athletes
Authors: Johnston Richard J. , Watsford Mark L. , Pine Matthew J. , Spurrs Robert W.
Published: December 2014

Running acceleration data provides important information about the physical demands placed on field sport athletes. However, the absence of clearly defined acceleration zones has contributed to the minimal examination of this variable. This study aimed to develop a standardised set of acceleration zones and determine any differences in accelerations between elite and sub-elite Australian footballers. Thirty-nine professional male Australian footballers performed a 30 m sprint from a standing start. Timing lights were placed at 0, 10, 20 and 30 m to calculate accelerations over 0–10, 10–20 and 20–30 m splits. The accelerations over these splits were 3.27 m·s−2, 1.81 m·s−2 and 0.33 m·s−2. The differences between the elite and sub-elite groups for time, velocity and acceleration over the splits were examined using independent t-tests and effect sizes. Acceleration zones were determined by using maximal acceleration to establish the subsequent acceleration zones. In this case 20%, 45% and 85% of maximum acceleration were used to develop low (0.65–1.46 m·s−2), moderate (1.47–2.77 m·s−2) and high (>2.78 m·s−2) zones. No differences between the elite and sub-elite athletes for each acceleration category were found. The development of standardised acceleration zones will assist with the assessment and understanding of accelerations in field sport athletes. This has the potential to improve the implementation of training programs and recovery sessions. Further, these accelerations zones are seemingly applicable for both elite and sub-elite field sport athletes.
An Ecological Approach to the Supervisory Control of UAV Swarms
Authors: Fuchs Christian , Borst Clark , de Croon Guido C. H. E. , van Paassen M. M. (René) , Mulder Max
Published: December 2014

Advances in miniaturized computer technology have made it possible for a single Unmanned Aerial Vehicle (UAV) to complete its mission autonomously. This also sparked interest in having swarms of UAVs that are cooperating as a team on a single mission. The level of automation involved in the control of UAV swarms will also change the role of the human operator. That is, instead of manually controlling the movements of the individual UAVs, the system operator will need to perform higher-level mission management tasks. However, most ground control stations are still tailored to the control of single UAVs by portraying raw flight status data on cockpit like instruments. In this paper, the ecological interface design paradigm is used to enhance the human-machine interface of a ground control station to support mission management for UAV swarms. As a case study, a generic ground-surveillance mission with four UAVs is envisioned. A preliminary evaluation study with 10 participants showed that the enhanced interface successfully enables operators to control a swarm of four UAVs and to resolve failures during mission execution. The results of the evaluation study showed that the interface enhancements promoted creative problem-solving activities to scenarios that could not have been solved by following a fixed procedure. However, the results also showed that the current interface still required control actions to be performed per single UAV, making it labor intensive to change mission parameters for swarms consisting of more than four UAVs.
Effect of Chordwise Deformation on Unsteady Aerodynamic Mechanisms in Hovering Flapping Flight
Authors: Noyon T. A. , Tay W. B. , van Oudheusden B. W. , Bijl H.
Published: December 2014

A three-dimensional simulation of hovering flapping wings was performed using an immersed boundary method. This was done to investigate the effects of chordwise wing deformation on three important unsteady aerodynamic mechanisms found in flapping flight, namely Leading Edge Vortex (LEV) shedding, wake capture and clap and fling. A wing was modeled as a flat plate, flapping close to a symmetry plane. Three different deforming chords were defined, a rigid case, a case with maximum deformation at the trailing edge and increased angle of attack (AoA) near the leading edge, and a case with the maximum deformation in the center of the chord and decreased AoA near the leading edge. All cases had zero deformation at the wing root and maximal deformation at the wing tip. A higher AoA near the leading edge resulted in faster LEV buildup and faster buildup of lift. No shedding of the LEV was observed in any of the cases even when deformation caused a high AoA near the leading edge. A distinct dip in lift buildup was observed and shown to be caused by the interaction between the previously shed vortex and the newly developing LEV. This interaction occurred faster when the AoA at the leading edge was increased, and slower when the angle of attack was decreased. Moving the wing closer to the symmetry plane had a positive effect on the cycle average value of CL. This positive effect was reduced however by the earlier interaction between the LEV and the previously shed vortex.
Detecting miRNA Mentions and Relations in Biomedical Literature
Authors: Bagewadi Shweta , Bobić Tamara , Hofmann-Apitius Martin , Fluck Juliane , Klinger Roman
Published: December 2014

Introduction: MicroRNAs (miRNAs) have demonstrated their potential as post-transcriptional gene expression regulators, participating in a wide spectrum of regulatory events such as apoptosis, differentiation, and stress response. Apart from the role of miRNAs in normal physiology, their dysregulation is implicated in a vast array of diseases. Dissection of miRNA-related associations are valuable for contemplating their mechanism in diseases, leading to the discovery of novel miRNAs for disease prognosis, diagnosis, and therapy.

Motivation: Apart from databases and prediction tools, miRNA-related information is largely available as unstructured text. Manual retrieval of these associations can be labor-intensive due to steadily growing number of publications. Additionally, most of the published miRNA entity recognition methods are keyword based, further subjected to manual inspection for retrieval of relations. Despite the fact that several databases host miRNA-associations derived from text, lower sensitivity and lack of published details for miRNA entity recognition and associated relations identification has motivated the need for developing comprehensive methods that are freely available for the scientific community. Additionally, the lack of a standard corpus for miRNA-relations has caused difficulty in evaluating the available systems.

We propose methods to automatically extract mentions of miRNAs, species, genes/proteins, disease, and relations from scientific literature. Our generated corpora, along with dictionaries, and miRNA regular expression are freely available for academic purposes. To our knowledge, these resources are the most comprehensive developed so far.

Results: The identification of specific miRNA mentions reaches a recall of 0.94 and precision of 0.93.  Extraction of miRNA-disease and miRNA-gene relations lead to an F1 score of up to 0.76. A comparison of the information extracted by our approach to the databases miR2Disease and miRSel for the extraction of Alzheimer's disease related relations shows the capability of our proposed methods in identifying correct relations with improved sensitivity. The published resources and described methods can help the researchers for maximal retrieval of miRNA-relations and generation of miRNA-regulatory networks.

Availability: The training and test corpora, annotation guidelines, developed dictionaries, and supplementary files are available at http://www.scai.fraunhofer.de/mirna-corpora.html
Revised typifications of Orchis morio and its Linnaean varieties (Orchidaceae): What descriptions may tell about their corresponding material
Authors: Sennikov Alexander N. , Efimov Petr G. , Kuropatkin Vladislav V.
Published: December 2014

Upon a detailed analysis of the protologue of Orchis morio var. mascula and elements associated with it, we demonstrate that Linnaeus based its original diagnosis on only one specimen and one illustration. The previously designated lectotype of O. morio var. mascula, which is not referable to O. mascula in its current taxonomic circumscription, is not part of the original material but is to be taken as neotype superseded here under Art. 9.19(a) in favour of a specimen from Burser’s Hortus Siccus. The typifications of O. morio and O. morio var. angustifolia are revised as well; the first lectotypes of these names are corrected to neotypes, and a new lectotype is designated here for O. morio.
Correction to Hepper and Friis’s analysis of Flora Aegyptiaco‐Arabica: Nepeta nepetellae Forssk. (Lamiaceae)
Authors: Ryding Olof , Friis Ib
Published: December 2014

The name Nepeta nepetellae has been accepted in Carl Christensen’s standard index to Forsskål’s Flora Aegyptiaco‐Arabica, listed in Index Kewensis and IPNI, listed as an accepted name in The Plant List and accepted in Hepper and Friis’s revision of the plants of Forsskål’s Flora Aegyptiaco‐Arabica. If accepted, N. nepetellae may threaten names in current use in Arabia and Africa. However, the name is so similar to the earlier N. nepetella L. that the two names are likely to be confused. Nepeta nepetellae is rejected as a later illegitimate homonym of N. nepetella, which will remove the threat to the currently used names and clarify a complex nomenclatural situation, which has confused several previous authors on the subject. The meanings of asterisked names in Flora Aegyptiaco‐Arabica and their bearing for N. nepetellae are briefly reviewed.
Rules of succession to the throne in the Muscovy of the 14th
Authors: Рожнов Артемий , Rozhnov Artemiy
Published: December 2014

The article concerns a problem of rules of succession to

the throne in the Muscovy of the 14th — 17th centuries. The author

comes to the conclusion that in the Muscovy the succession to the

throne was regulated by customary law and the royalty was delegated

from father to the eldest son. This rule of succession to the throne

had various advantages in comparison with other forms of the succession

of the supreme power.
Pregnancy, lactation and avoidance of allergy in the infant
Authors: Coutts Alison
Published: December 2014

There appears to be an enormous increase in allergic and auto-immune disorders. These range from hay fever to diabetes, rheumatoid arthritis and asthma. There is little explanation as to why this is. One theory (discussed in Hamilton, 1998) is that modern practices – such as excessive use of antibacterial agents – have minimized the number and variety of pathogens that the individual has to cope with, and so the immune sytern becomes misdirected into attacking harmless or even helpful items such as certain foods.
Letters
Authors: Hayes Jane , Stephens Liz , Rogers Jane , Jones MH , Brown Sarah
Published: December 2014

Liz Stephens’ article (July 1998) was written over a year ago, I wonder if her views are still the same today. I feel she is describing an era which has long since passed. I believe the working relationship between obstetricians has improved vastly in recent years.
Changing to ‘new style’ antenatal care
Authors: Johnson Gina
Published: December 2014

This study describes the effects of introducing ‘new style’ antenatal care into South Bedfordshire; a reduced schedule of routine visits and an increased emphasis on community care. During the planning stage, professionals and new mothers were consulted. Guidelines for antenatal care were jointly developed by midwives, GPs and obstetricians. A significant reduction was achieved in the mean number of antenatal visits from 11.7 to 10 after the new system had been in operation for 21 months. Mothers' acceptance of the reduced visits schedule was low, but increased after it had been introduced. Initially, 80% of women were against the change; later this propotion had fallen to 46%. The care of women who developed hypertension in pregnancy was also audited; the proportion of women who managed according to the guidelines increased from 58% to 93% in those with borderline raised blood pressure, and from 57% to 95% in those with diastolic pressures above 100mmHg.
G1957C variation in Core Promoter and Precore/Core regions of Hepatitis B virus isolated from men who have sex with men (MSM) in Surakarta, Central Java, Indonesia
Authors: PRASETYO AFIONO AGUNG , SARIYATUN RATNA , PRASETYO ANGGA DWI , YUDISTIRO IBNU , SIDHAJATI RADEN ARTHESWARA
Published: December 2014

Abstract. Prasetyo AA, Sariyatun R, Prasetyo AD, Yudistiro I, Sidhajati RA. 2014. G1957C variation in Core Promoter and Precore/Core regions of Hepatitis B virus isolated from men who have sex with men (MSM) in Surakarta, Central Java, Indonesia. Nusantara Bioscience 6: 107-110. Little is known about HBV isolates in Indonesian men who have sex with men (MSM) community. Thus, this study was aimed to analyze the genetic profile of HBV isolated from MSM in Indonesia, particularly in Surakarta, Central Java. A total of 205 blood samples were examined by polymerase chain reaction (PCR) targeting the partial Core Promoter (CP) and Precore/Core (preC/C) regions. Three samples were found positive by PCR. The amplicons were sequenced and subjected to molecular analysis. The genetic profile of all HBV isolated in Indonesia (n= 122) was also included for molecular analysis. All HBV isolated from the MSM were genotype B3. G1957C (C195S) was found in all HBV isolated from the MSM community and subject with sex with man history. Several disease-related mutations were observed among HBV sequences from Indonesia, including T1753C, A1762T, G1764A, A1846T, and G1896A which existed in 7.2% (9/125), 17.6% (22/125), 19.2% (24/125), 16.8% (21/125), and 24.8% (31/125) sequences, respectively; however, none were present in HBV isolated from the MSM. In conclusion, various mutations, including those related to disease, were found in Indonesian HBV isolates. G1957C variation was unique in the HBV isolated from the MSM.
Endophytic Phoma sp. isolated from medicinal plants promote the growth of Zea mays
Authors: KEDAR ASHWINI , RATHOD DNYANESHWAR , YADAV ALKA , AGARKAR GAURAVI , RAI MAHENDRA
Published: December 2014

Kedar A, Rathod D, Yadav A, Agarkar G, Rai M. 2014. Endophytic Phoma sp. isolated from medicinal plants promote the growth of Zea mays. Nusantara Bioscience 6: 132-139. Fungal endophytes are reported as rich sources of valuable secondary metabolites and could be used as bio-fertilizers. In the present study, we report growth promotion potential of two Phoma species isolated from Tinospora cordifolia and Calotropis procera on maize. The fungal endophytes enhanced growth in inoculated maize plants compared to non-inoculated plants. The main aim of this work was to assess the growth promotion activity of endophytic Phoma species on maize isolated from T. cordifolia and C. procera.
Short Communication: Contamination of cell phones by pathogenic microorganisms: Comparison between hospital staff and college students
Authors: CHITLANGE PURNIMA R.
Published: December 2014

Abstract. Chitlange PR. 2014. Contamination of cell phones by pathogenic microorganisms: Comparison between hospital staff and college students. Nusantara Bioscience 6: 203-206. Cell phone (CP) is a long range portable electronic device. The cell phone is constantly exposed to arrays of microorganisms, making it a harbor and breeding ground for microbes especially those associated with skin. The adult human is covered with approximately 2m2 of skin with area supporting about 106 bacteria. To check whether the cell phone act as a vector for transmission of various pathogens, a potential study was carried out in Microbiology Department of Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola, Maharashtra, India. Total of 20 cell samples was screened. Two parameters were considered: College students and hospital staff. The isolated bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas sp., Bacillus subtilis, Aerobacter aerogenes, Salmonella, Shigella, Streptococci, P. vulgaris were identified on the basis of morphological and cultural characteristics. The main aim of present study was to check the contamination by bacterial pathogens on cell phones and also to check role of cell phone for transmission of pathogens from person to person or not.
Transplantation of carica (Vasconcellea pubescens) at various altitudes of Mount Lawu, Central Java with treatment of shade and different types of fertilizers
Authors: PERMATASARI ALFATIKA , SUGIYARTO SUGIYARTO , MARSUSI MARSUSI , HAILU HAILU WELDEKIROS
Published: December 2014

Abstract: Permatasari A, Sugiyarto, Marsusi, Hailu WH. 2015. Transplantation of carica (Vasconcellea pubescens) at various altitudes of Mount Lawu, Central Java with treatment of shade and different types of fertilizers. Nusantara Bioscience 7: 6-14. Ex-situ conservation efforts to increase crop production can be done by means of transplantation. The aim of this study was to assess the effect of altitude, shade, and type of fertilizer and their interactions to the performance of carica (Vasconcellea pubescens) vegetative plants transplanted to Mount Lawu, Central Java, Indonesia. The research was conducted in divided plot design at three altitudes (± 1400, 1600 and 1800 m asl.) with shade treatment as main plots and fertilizer (manure, Zwavelzuur ammonium/ZA fertilizer, combination of manure with Ammonium fertilizer, and control) as subplots. Parameters of vegetative variability were observed. The results of the performance of carica vegetative plant were analyzed using ANOVA followed by Duncan's test at 5% standard test. It was observed that an increase in altitude caused slower growth of carica vegetative parts, but better vegetative growth performance in the presence of shade. For the fertilizers, the best growth parameters were obtained in the treatment of manure with ZA fertilizer. Interaction between altitude, shade, and type of fertilizer significantly influenced the performance of carica vegetative parameters. The best growth parameters are at an altitude of 1400 m above sea level with shade treatment and manure combined with ZA fertilizer.
RESOLUÇÃO DE CONFLITOS E PROBLEMAS DE ABUSO PATERNO DO ÁLCOOL
Authors: Vicentin Vanessa Fagionatto , Leme Maria Isabel Da Silva
Published: December 2014

O objetivo do presente estudo foi analisar o impacto do alcoolismo parental sobre a resolução de conflitos por adolescentes. A amostra foi composta por 84 estudantes de ensino fundamental e médio de uma escola pública de nível socioeconômico baixo, com idades entre 12 e 16 anos e, divididos em dois grupos: 42 filhos de pais com problemas de álcool e 42 participantes que não se enquadravam nesse grupo. Os instrumentos utilizados foram: Questionário CAGE Familiar e a versão aberta da escala The Children’s Action Tendency Scale. Os adolescentes apresentaram predominantemente respostas submissas, seguidas de respostas agressivas. Não foi encontrada diferença significativa entre os filhos de pais com e sem problemas de álcool. Contudo, a análise de correspondência múltipla mostrou que as respostas agressivas estão mais associadas à presença de problemas de álcool enquanto as respostas assertivas à ausência destes problemas.http://dx.doi.org/10.14572/nuances.v25i3.3020
EDUCAÇÃO INFANTIL E AVALIAÇÃO: UMA AÇÃO MEDIADORA
Authors: Da Silva Juliana Pereira , Urt Sonia Da Cunha
Published: December 2014

Tem-se como objetivo analisar algumas propostas práticas de avaliação na Educação Infantil, visando à valorização desta como uma ação mediadora e de maior reflexão, capaz de incentivar de forma sistemática e consciente, o acompanhamento e desenvolvimento da criança. Nesse contexto, demonstram-se os dispositivos legais que subsidiam a avaliação para Educação Infantil, suas concepções e sua importância em âmbito da aprendizagem e desenvolvimento da criança, bem como também, da prática do professor. Faz-se referência à Teoria Histórico-Cultural para explicar o processo de aprendizagem e como acompanhá-lo de forma qualitativa. Dessa forma, posteriormente à revisão bibliográfica faz-se uma apresentação e análise de alguns trabalhos avaliativos, conclui-se que a avaliação na Educação Infantil, é um processo que se materializa em várias ações que contemplam todo o percurso de aprendizagem e desenvolvimento da criança, do professor e da instituição.http://dx.doi.org/10.14572/nuances.v25i3.3038
CONTEXTOS E PRÁTICAS DE AVALIAÇÃO NA EDUCAÇÃO INFANTIL
Authors: Côco Valdete , Vieira Maria Nilceia de Andrade
Published: December 2014

Este artigo apresenta dados de uma pesquisa que aborda práticas de avaliação na Educação Infantil (EI) no estado do Espírito Santo (ES), Brasil. A partir de diferentes dimensões avaliativas vivenciadas em instituições de EI nos 78 municípios, realiza-se uma interlocução com a legislação brasileira e as produções acadêmicas desse campo. Com ancoragem em referenciais teórico-metodológicos bakhtinianos, considera-se o movimento dialógico dos diversos enunciados na composição das práticas de avaliação na EI. A análise comparativa dos dados focaliza a avaliação das crianças, a avaliação institucional e a avaliação de desempenho profissional, apontando para a necessidade de momentos formativos que abordem a complementaridade entre essas modalidades avaliativas, e destacando que a avaliação das crianças, a partir das práticas pedagógicas, deve se basear num protagonismo compartilhado entre crianças e docentes no cotidiano das instituições de EI.http://dx.doi.org/10.14572/nuances.v25i3.3087
PROMOÇÃO DA AUTORREGULAÇÃO DA APRENDIZAGEM DAS CRIANÇAS: PROPOSTA DE INSTRUMENTO DE APOIO À PRÁTICA PEDAGÓGICA
Authors: Piscalho Isabel Alexandra Damasceno , Simão Ana Margarida Veiga
Published: December 2014

Após estudo prévio em que se analisaram as perspetivas de investigadores, educadores de infância e professores do 1º ciclo do ensino básico com o objetivo de estudar estratégias de suporte que proporcionem oportunidades efetivas e essenciais ao desenvolvimento de competências de autorregulação nas crianças dos 5 aos 7 anos, apresenta-se um desenho de uma investigação em que se procura fundamentar a necessidade de promover a reflexão sobre a prática pedagógica, assegurando a continuidade educativa, com vista à promoção precoce de competências de autorregulação da aprendizagem. Propõe-se a docentes e alunos-estagiários que utilizem a Checklist of Independent Learning Development (CHILD) e, através da análise das suas narrativas, pretendemos apurar as potencialidades desse instrumento na reflexão, identificação e avaliação das abordagens educativas dos participantes a fim de as ajustarem às necessidades das crianças em transição escolar e ao desenvolvimento de processos autorregulatórios.http://dx.doi.org/10.14572/nuances.v25i3.3163
A QUALIDADE DO CONTEXTO NA EDUCAÇÃO DE INFÂNCIA PERSPETIVADA ATRAVÉS DA ESCOLHA E DO ENVOLVIMENTO
Authors: Lino Dalila
Published: December 2014

As escolhas que fazemos ao longo do nosso percurso de vida definem quem somos, quer do ponto de vista pessoal quer do ponto de vista profissional e social. O principal objetivo deste estudo é avaliar e promover o desenvolvimento de um curriculum para a educação de infância que promova a competência da escolha e tomada de decisão das crianças em idade pré-escolar. A metodologia usada é o estudo de caso de natureza qualitativa e os dados são recolhidos através da Escala do Envolvimento e da análise das planificações das educadoras. O estudo desenvolveu-se em 3 salas de educação pré-escolar da rede pública e envolveu 48 crianças e 3 educadoras de infância. Os dados sugerem que existe uma relação entre a competência da escolha e tomada de decisão das crianças e o seu envolvimento nas atividades, quer nas atividades auto iniciadas quer nas atividades propostas pelas educadoras. A análise dos dados é sustentada nas teorias e abordagens pedagógicas de Dewey, Freinet, Malaguzzi e Weikart.http://dx.doi.org/10.14572/nuances.v25i3.3201
Need for Cognitive Closure, Risk Aversion, Uncertainty Changes, and Their Effects on Investment Decisions
Authors: Disatnik David , Steinhart Yael
Published: December 2014

Investment decisions play a crucial role in the way consumers manage their wealth, and therefore, it is important to understand how consumers make these decisions. This research contributes to this attempt by examining consumers’ investment decisions in response to new information about changes in uncertainty in financial markets. The authors identify possible conditions under which consumers, despite having new information about changes in market uncertainty, are less likely to assimilate the new information and consequently do not make investment decisions that are in line with their risk-aversion levels. Specifically, in a series of studies, the authors show that high rather than low need for cognitive closure can lead to a lack of openness to new information and therefore may dilute consumers’ tendency to update their investment portfolios in a way that reflects their risk preferences. In addition, the authors address possible ways to influence consumers’ assimilation of new information, to help even those with high need for cognitive closure make investment decisions that are in line with their levels of risk aversion.
The heterogeneity of hyperinsulinaemic hypoglycaemia in 19 patients with Beckwith-Wiedemann syndrome due to KvDMR1 hypomethylation
Authors: Senniappan Senthil , Ismail Dunia , Shipster Caroleen , Beesley Clare , Hussain Khalid
Published: December 2014

Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome caused by multiple epigenetic and genetic changes affecting imprinted genes on chromosome 11p15.5. Hypomethylation of KvDMR1 on the maternal allele is the most common genetic cause, and hyperinsulinaemic hypoglycaemia (HH) is the most common biochemical abnormality. We evaluated the correlation between severity of HH and degree of hypomethylation in BWS. Out of the 19 patients with BWS due to KvDMR1 hypomethylation, 10 patients had no HH, 5 had mild transient HH that resolved spontaneously, and 4 required diazoxide therapy for up to 6 months. There was no correlation between the degree of KvDMR1 hypomethylation and severity of HH in the 6 patients studied. All patients also showed marked clinical heterogeneity with respect to the features of BWS. In patients with BWS due to hypomethylation of KvDMR1, the clinical presentation of HH is quite heterogeneous with no correlation with the degree of KvDMR1 hypomethylation.
Learning but Not Acting in Rural China
Authors: Pang Xiaopeng , Zeng Junxia , Rozelle Scott
Published: December 2014

This paper studies women’s participation in village elections. It focuses on the impact of voting rights training on women’s knowledge, and their voting behaviors in Ningxia, China, a Hui nationality autonomous region with a conservative cultural environment for women. A randomized controlled trial has been used in the study.
Indeterminacy, Free Improvisation, and the Mixed Avant-Garde:
Authors: Piekut Benjamin
Published: December 2014

John Cage's brand of experimentalism underwent a transformation when it was imported into the UK in the 1960s. There, in contradiction to the American's well-known preferences, indeterminacy became twisted up with jazz-derived free improvisation, owing to discourse that stressed performer freedom and creativity while downplaying notions of non-intention and discipline. The authors of these commentaries created the discursive conditions for a mingling of avant-garde traditions, but the material conditions owed more to the efforts of Victor Schonfield, whose nonprofit organization, Music Now, acquired Arts Council subsidies on behalf of a stylistically heterogeneous avant-garde that included artists working with both improvisation and indeterminacy. Schonfield also invited important guests from overseas, including Ornette Coleman, Musica Elettronica Viva, the Sonic Arts Union, the Instant Composers Pool, Christian Wolff, Sun Ra, the Taj Mahal Travellers, and, in 1972, John Cage himself. In the greater ecology of experimentalism that Schonfield created, improvisation became a kind of contact zone where musicians came together from a number of directions, among them free jazz, score-based indeterminacy, text-based intuitive music, Fluxus-inspired instruction pieces, and even psychedelic rock freak-outs. Music Now produced over 80 concerts between 1968 and 1976, when the organization folded.
Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
Authors: Schiebler Mark , Brown Karen , Hegyi Krisztina , Newton Sandra M , Renna Maurizio , Hepburn Lucy , Klapholz Catherine , Coulter Sarah , Obregón‐Henao Andres , Henao Tamayo Marcela , Basaraba Randall , Kampmann Beate , Henry Katherine M , Burgon Joseph , Renshaw Stephen A , Fleming Angeleen , Kay Robert R , Anderson Karen E , Hawkins Phillip T , Ordway Diane J , Rubinsztein David C , Floto Rodrigo Andres
Published: December 2014

Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of macroautophagy might provide a novel therapeutic strategy. Despite the resistance of MTB to killing by basal autophagy, cell‐based screening of FDA‐approved drugs revealed two anticonvulsants, carbamazepine and valproic acid, that were able to stimulate autophagic killing of intracellular M. tuberculosis within primary human macrophages at concentrations achievable in humans. Using a zebrafish model, we show that carbamazepine can stimulate autophagy in vivo and enhance clearance of M. marinum, while in mice infected with a highly virulent multidrug‐resistant MTB strain, carbamazepine treatment reduced bacterial burden, improved lung pathology and stimulated adaptive immunity. We show that carbamazepine induces antimicrobial autophagy through a novel, evolutionarily conserved, mTOR‐independent pathway controlled by cellular depletion of myo‐inositol. While strain‐specific differences in susceptibility to in vivo carbamazepine treatment may exist, autophagy enhancement by repurposed drugs provides an easily implementable potential therapy for the treatment of multidrug‐resistant mycobacterial infection.
Case Report: Rapidly Healing Epidermolysis Bullosa Wound After Ablative Fractional Resurfacing
Authors: Krakowski Andrew C. , Ghasri Pedram
Published: December 2014

Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis characterized by generalized skin fragility, severe blistering, and wounding that heals with mutilating scarring. Patients are in constant need of effective wound therapies as they often succumb to aggressive metastatic squamous cell carcinomas or to sepsis that may develop from their chronic wounds. Herein, we demonstrate accelerated wound healing with use of a fractionated CO2 laser protocol in a 22-year-old man with RDEB. His 9-month-old, non-healing wound decreased from 7 cm in diameter to 2 cm in diameter (a 92% reduction in wound surface area) within 4 weeks of a single laser treatment, and he had near-complete re-epithelialization within 4 weeks of his second laser treatment without blistering or other adverse effects. This novel intervention of using fractionated CO2 for photo-microdebridement could help revolutionize wound care for patients who have RDEB and whose chronic wounds serve as one of their greatest sources of morbidity and mortality. Dissemination to a pediatric audience is critical so that laser protocols might be more thoroughly investigated and incorporated into wound management strategies for this uniquely vulnerable population.
DEVELOPMENT OF FUSION RECOMBINANT PROTEINS BASED ON VP6 AND VP8 OF HUMAN ROTAVIRUS A
Authors: Dukhovlinov I. V. , Bogomolova E. G. , Fedorova E. A. , Simbirtsev A. S.
Published: December 2014

Rotaviruses are the most frequent cause of children enteritis. This infection often leads to severe dehydration of organism. Many infectious diseases are accompanied by fluid loss being the most common cause of death. Nowadays an early vaccination is considered to be the most effective way for prevention of rotavirus infection. However attenuated alive vaccines are used for this purpose which can result in different complications. The candidate vaccine presented in this study was designed on the basis of recombinant fusion proteins — the crucial active agents for development of immune response against rotaviruses. As part of the study the following steps were taken: the design of fusion proteins VP6VP8 and FliCVP6VP8; protocol adjustment for induction of genes encoding these proteins expression, which yields in high level of the protein with minor expenditures; production and purification of recombinant proteins VP6VP8 and FliCVP6VP8 with metal affinity chromatography.
INCIDENCE OF RUBELLA IN NORTH WEST RUSSIA ON THE STAGE OF ELIMINATION OF RUBELLA
Authors: Bichurina M. A. , Lavrentyeva I. N. , Zheleznova N. V. , Antipova A. Yu. , Timofeeva E. V.
Published: December 2014

Analysis of incidence of Rubella in the period of 2001–2013 on the territory of North West Federal Region of Russia evidences that the large scaled vaccination in the frames of the “Public Health” National Project considerably influenced the epidemical process of the rubella virus infection (RVI). However at the same time besides the drastic decrease of Rubella incidence to sporadic level (0.4 per 100 000 in 2013) and limited transmission of RVI the shift of Rubella incidence to the eldest age groups was observed: 94% of patients with RVI in 2013 were more than 17 years old. Among Rubella cases the vaccinated patients consisted 3.7% in 2013 and revaccinated 7.1% in 2012. According to gender distribution males with RVI were revealed more frequently than females. The outbreak of Rubella in one of the Military Colleges is described. At present time RV strains of 2B genotype circulate in North West Russia. Cases of wrong clinical diagnosis of Rubella were revealed: in 2011–2013 only for 19% of patients the Rubella was laboratory confirmed. Thus on the stage of the elimination of Rubella the verification of each Rubella case is extremely necessary.
CRYOGLOBULINEMIC VASCULITIS ASSOCIATED WITH HBV INFECTION: CLINICAL OBSERVATIONS AND LITERATURE REVIEW
Authors: Dunaeva N. V. , Nikitina O. E. , Stukov B. V. , Karev V. E. , Mazing A. V. , Lerner M. Y. , Lapin S. V. , Totolian Areg A.
Published: December 2014

Description of two clinical cases of chronic HBV hepatitis at cirrhotic stage associated with type III cryoglobulinemia manifested with symptoms of systemic vasculitis is presented in current article. There were no signs of HCV infection in both patients. In first case cutaneous vasulitis appeared after 19 years since serological finding of HBsAg and vasculitis progressed despite steroid therapy. Initiation of antiviral therapy (entecavir 0.5 g/day) induced transient remission. After interruption of antiviral therapy vasculitis reappeared with several vasculitic ulcers on lower legs. Mild improvement of vasculitis was noted after repeated plasmapheresis, steroid and cytostatic treatment with addition of lamivudin. Despite therapy reactivation of HBV infection was detected. Lamivudin was changed to entecavir and rituximab was given in two 500 mg infusions. Combined antiviral and anti-CD20 treatment induced remission of cutaneous vasculitis and healing of leg ulcers. In other case vasculitis manifested after 21 years since detection of HBsAg with cutaneous purpura, arthritis and microhematuria. Entecavir 0.5 g/day induced rapid virological response and complete remission of symptoms related to vasculitis. Similar literature cases were reviewed and available treatment options in refractory cryoglobulinemic vasculitis were discussed.
Corpus Inscriptionum Iudaeae/Palaestinae. Vol. I: Jerusalem. Part 2: 705–1120. Edited by Hannah M. Cotton, Leah Di Segni, Werner Eck, Benjamin Isaac, Alla Kushnir-Stein, Haggai Misgav, Jonathan Price, Ada Yardeni with contributions by Robert Daniel, Denis Feissel, Robert Hoyland, Robert Kool, Eran Lupu, Michael Stone, Yana Tchekhanovets with the assistance of Marfa Heimbach, Dirk Koßmann, Naomi Schneider.
Authors: Gatier Pierre-Louis
Published: December 2014

Corpus Inscriptionum Iudaeae/Palaestinae. Vol. I: Jerusalem. Part 2: 705–1120. Edited by Hannah M. Cotton, Leah Di Segni, Werner Eck, Benjamin Isaac, Alla Kushnir-Stein, Haggai Misgav, Jonathan Price, Ada Yardeni with contributions by Robert Daniel, Denis Feissel, Robert Hoyland, Robert Kool, Eran Lupu, Michael Stone, Yana Tchekhanovets with the assistance of Marfa Heimbach, Dirk Koßmann, Naomi Schneider. Berlin/Boston: de Gruyter 2012. XVI, 572 S. zahlr. Abb. 3 Ktn. 129,95 €.
Emanuele Greco: Topografia di Atene. Sviluppo urbano e monumenti dalle origini al III secolo d.C. con la collaborazione di Fausto Longo, Daniela Marchiandi, Maria Chiara Monaco, Riccardo Di Cesare, Giovanni Marginesu. Tomo 1: Acropoli – Areopago – Tra Acropoli e Pnice. Tomo 2: Colline sud-occidentali – Valle dell’ Ilisso.
Authors: Krumeich Ralf
Published: December 2014

Emanuele Greco: Topografia di Atene. Sviluppo urbano e monumenti dalle origini al III secolo d.C. con la collaborazione di Fausto Longo, Daniela Marchiandi, Maria Chiara Monaco, Riccardo Di Cesare, Giovanni Marginesu. Tomo 1: Acropoli – Areopago – Tra Acropoli e Pnice. Tomo 2: Colline sud-occidentali – Valle dell’ Ilisso. Atene: Scuola Archeologica Italiana di Atene; Paestum: Edizioni Pandemos 2010/2011. 582 S. zahlr. Abb. 5 Beil. 4°. (Studi di Archeologia e di Topografia di Atene e dell’Attica (SATAA) 1).