bluuebunny/crossref_metadata_2025 huggingface dataset:
The Half-Sine Method: A New Accurate Location Method Based on Wavelet Transform for Transmission-Line Protection from Single-Ended Measurements
Authors: Martín Arroyo Susana , García-Gracia Miguel , Montañés Antonio
Published: August 2019

In this work, a new and accurate method based on the wavelet transform is proposed for fault location in transmission-line systems. The proposed wavelet method consists of the analysis of the transient signal measured at a single end of the transmission line. Aerial current modes are used, and zero modes are included in the fault-detection scheme for low fault-inception angles. The fault distance is evaluated using the wavelet modulus maxima technique and a method based on the response to a half-sine voltage is proposed to overcome drawbacks arising from the limited sampling frequency and low fault-inception angle. The fault distance is calculated using the difference between the time when a 100 kHz half-sine signal is sent and the time when the derivative signal is received. The proposed algorithm is tested considering harmonic distortion and varying fault resistance, ground resistivity, location and inception angle. The high accuracy of the proposed algorithm is obtained even for faults close to the bus and low inception angles.
Influence of Partial Arc on Electric Field Distribution of Insulator Strings for Electrified Railway Catenary
Authors: Zhao Shanpeng , Zhang Chenrui , Zhang Youpeng , Wang Sihua
Published: August 2019

The occurrence of a partial arc can affect insulation properties of the insulator by different types of flashover. In order to investigate the influence of a partial arc on electric field distribution along the catenary insulator string, a three-dimensional model of the cap-pin insulator string with partial arc was established in this paper. The electric field distribution along the insulator string when the arc extended on the insulator surface and bridged sheds was investigated based on the electric field analysis using the finite element method. The results showed that the occurrence of a partial arc caused obvious distortion of the electric field, which was a two-dimensional axis symmetrical field before arcing to a three-dimensional field. In the case of arc extension, the sudden rise of field intensity was mostly at the rib and the shed edge, which had the local maximum field intensity. The rib and the shed edge played a certain hindrance role in the extension of the arc. The main reason for promoting the development of the arc can be attributed to thermal ionization. In the case of arc bridge sheds, the highest field intensity appeared at the edge of the last bridged shed. As the number of sheds arc-bridged increased, the maximum field intensity also increased. As the arc length increased, the electric field intensity of the arc head also increased, which resulted in an accelerated arc development. The main factor to promote the development of the arc can be attributed to electrical breakdown. The measures to hinder the rapid development of partial arcs were proposed.
A Novel Design Concept of Electromagnetic Valve Actuator with High Starting Force
Authors: Munih Tomaž , Miljavec Damijan , Čorović Selma
Published: August 2019

In this study, a novel design concept of magnet-less, high response time electromagnetic valve actuator with high starting force for independent valve actuation control of internal combustion engines is proposed. The new actuator geometry design is based on the theoretical analysis of electromagnetic and mechanical properties of a curve shaped object rolling on a fixed surface, which may be either flat or curved. The prototype of the new electromagnetic valve actuator was built according to the results that were obtained with finite element based numerical modelling and analysis. Finally, the experimental measurements are performed and the theoretical predictions were confirmed by obtaining good agreement between the experimental and numerical simulation results.
Modeling and Control of a Novel Hybrid Power Quality Compensation System for 25-kV Electrified Railway
Authors: Chen Minwu , Chen Yinyu , Wei Mingchi
Published: August 2019

The severe power quality problems aroused by the single-phase 25-kV traction power supply system (TPSS), especially for the voltage unbalance (VU) and high-frequency harmonic resonance, have attracted increasing attention nowadays. In this paper, a novel hybrid power quality compensation system, including a power flow controller (PFC) and thyristor-controlled L and C-type filter (TCL-CTF), is proposed. The PFC can be used for VU compensation, and the TCL-CTF can be designed to filter out harmonics as well as compensate reactive power. Furthermore, an optimized compensation strategy is proposed, and the power quality of the TPSS can meet the requirements of the technology standard. Compared with the conventional scheme, the compensation capacity of the PFC can be reduced by 12%, as well as the cost. Finally, the effectiveness of the proposed system is verified by the simulation and experimental results.
Sustainability Assessment of Alternative Strip Clear Cutting Operations for Wood Chip Production in Renaturalization Management of Pine Stands
Authors: Schweier Janine , Blagojević Boško , Venanzi Rachele , Latterini Francesco , Picchio Rodolfo
Published: August 2019

In Mediterranean regions, afforested areas were planted to ensure the permanence of land cover, and to protect against erosion and to initiate the vegetation processes. For those purposes, pine species were mainly used; however, many of these stands, without silvicultural treatments for over fifty-sixty years, were in a poor state from physical and biological perspective, and therefore, clear-cutting on strips was conducted as silvicultural operation with the aim to eliminate 50% of the pine trees and to favor the affirmation of indigenous broadleaves seedlings. At the same time, the high and increasing demand of the forest based sector for wood biomass related to energy production, needs to be supplied. In a modern and multifunctional forestry, in which society is asking for sustainable forestry and naturalistic forest management, forestry operations should ideally be carried out in a sustainable manner, thus support the concept of sustainable forest management. All these aspects are also related to the innovation in forestry sector for an effective energetic sustainability. Three different forest wood chains were applied in pine plantations, all differing in the extraction system (animal, forestry-fitted farm tractor with winch, and double drum cable yarder). The method of the sustainability impact assessment was used in order to assess potential impacts of these alternative management options, and a set of 12 indicators covering economic, environmental, and social dimensions was analyzed. Further, to support decision makers in taking informed decisions, multi-criteria decision analysis was conducted. Decision makers gave weight towards the indicators natural tree regeneration and soil biological quality to support the achievement of the forest management goal. Results showed that first ranked alternative was case 2, in which extraction was conducted by a tractor with a winch. The main reason for that lies in the fact that this alternative had best performance for 80% of the analyzed criteria.
Appropriate Removal of Forest Litter is Beneficial to Pinus tabuliformis Carr. Regeneration in a Pine and Oak Mixed Forest in the Qinling Mountains, China
Authors: Huo Xueying , Wang Dexiang , Bing Deye , Li Yuanze , Kang Haibin , Yang Hang , Wei Guoren , Chao Zhi
Published: August 2019

Research Highlights: Natural regeneration is important in pine–oak mixed forests (Pinus armandii Franch., Pinus tabuliformis Carr., and Quercus aliena Bl. var. acuteserrata Maxim.ex Wenz.), but allelopathy as a limiting factor has not been studied. Our research provides insights into allelopathy in pine–oak mixed forest litter. Background and Objectives: Allelopathy among tree species occupying the same ecological niche in mixed forests may adversely affect regeneration. We studied allelopathy in pine and oak forest litter to determine the effect on regeneration, whether it is offset by adding activated carbon or plant ash, and what allelopathic substances are present. Materials and Methods: We used laboratory seed culture and field seeding to determine pine and oak litter regeneration effects on P. tabuliformis and P. armandii in the Qinling Mountains, China. In the laboratory, we irrigated seeds with three different litter concentrations. A fourth treatment incorporated activated carbon. The field study established small quadrats in mixed forest to study how removing or retaining litter and spreading plant ash affected sown seeds. High performance liquid chromatography–mass spectrometry was used to compare differences in chemical substances in extracts with and without activated carbon. Results: Litter extracts significantly affected germination rates in both species. Seedling morphological and physiological indexes showed that litter extracts negatively affected growth in both species, but activated carbon alleviated this inhibitory effect on P. armandii. Forest stand and litter did not affect P. armandii seed germination. Pinus tabuliformis germination rates were significantly higher in plots with removed litter than when litter was retained or plant ash spread, and lower in oak than pine forest. Allelopathic substances detected in pine forest were trioctyl trimellitate, amyloid β-Peptide 10–20, and triisobutyl phosphate, potentially affecting P. armandii seed germination and growth. Conclusions: Appropriate removal of litter in mixed forests can improve the natural regeneration ability of P. tabuliformis.
Structural Changes Induced by Pulsed Electric Fields Increase the Concentration of Volatiles Released in Red Onion (Allium cepa L. var. Red Pearl) Bulbs
Authors: Tantamacharik Thirawat , Leong Sze Ying , Leus Michelle J. , Eyres Graham T. , Burritt David J. , Oey Indrawati
Published: August 2019

This study investigated whether pulsed electric field (PEF) treatment can induce structural changes of whole, intact red onion bulb (Allium cepa L. var. Red Pearl). Onion bulbs were treated at electric field strengths of 0.6 and 1.2 kV/cm combined with energy inputs of 6 and 60 kJ/kg at different onion orientations with respect to the high voltage electrode. Results showed that onion cells across all fleshy scales experienced uniform cell damage with a higher proportion (>80%) of non-metabolically viable cells after PEF treatment at 1.2 kV/cm when the root end was positioned facing toward the PEF electrode. The findings were supported by cryogenic-scanning electron micrographs (cryo-SEM), where the underlying storage circular cells were completely damaged owing to the PEF treatment. In this study, it was found that the treatment intensity of PEF to induce structural damage across all the scale layers of an onion bulb coincided with an increase in dipropyl disulfide (DPDS) released from the onion bulbs. Therefore, DPDS was used as a volatile marker indicating cellular disruption within whole, intact onion bulbs. A considerable increase of DPDS, up to 52-fold, was detected from PEF-treated onion bulbs compared to untreated bulbs.
The Unique Granite Gorge in Mountainous Adygeya, Russia: Evidence of Big and Complex Geosite Disproportions
Authors: Mikhailenko Anna V. , Ruban Dmitry A. , Yashalova Natalia N. , Rebezov Maksim B.
Published: August 2019

Geological heritage sites (geosites) are subject to conservation and exploitation for science, education, and tourism. Some geosites are big and comprise diverse phenomena. Concentration of the latter in some parts of these geosites makes them disproportionate. A typical example is the Granite Gorge in SW Russia that is of recognizable tourism importance. It stretches for ~5 km and represents a deep valley of the Belaya River and Late Paleozoic granitoids of the Dakh Crystalline Massif. However, the full spectrum of unique features is much wider. Their inventory permits the establishment of geomorphological, igneous, metamorphic, sedimentary, mineralogical, paleogeographical, tectonic, economic, engineering, and hydrological and hydrogeological types of geological heritage. Spatial distribution of these types and the relevant features indicates their significant concentration near the northern entrance to the gorge and a less important concentration near the southern entrance. This is evidence of geosite disproportion. Apparently, the latter implies the need to focus geoconservation and geotourism activities on the noted loci of concentration. However, this would ’disrupt’ the geosite integrity, and, thus, management of the Granite Gorge geosite requires attention to all its parts, including those with lower heritage value.
Has the High-Tech Industry along the Belt and Road in China Achieved Green Growth with Technological Innovation Efficiency and Environmental Sustainability?
Authors: Li Chang , Li Mingyang , Zhang Lu , Li Tingyi , Ouyang Hanzhen , Na Sanggyun
Published: August 2019

From the perspective of green growth, which seeks to coordinate and make sustainable the development of resources, the environment, and the economy, this study’s aim was to find out whether the high-tech industry along the Belt and Road (B&R) is sustainable and effective in using resources, reducing environmental pollution, and increasing performance. This study used panel data covering 16 provinces (municipalities) along the B&R in China between 2009 and 2016. This study used the directional distance function (DDF) and the global Malmquist–Luenberger (GML) index model to analyze the technological innovation efficiency (TIE) of the high-tech industry (HTI) while considering the undesirable output (environmental pollution). Further, supplemented by ArcGIS geographical analysis, this study carried out a comparative analysis of the TIE and its decomposition in the HTI along the B&R from geographical and time-series dimensions. Moreover, the panel Tobit regression model was used to analyze the influencing factors of TIE. The results show that the direct financial support of the government has no impact on the improvement of TIE in the HTI, the government’s regulation of environmental pollution can significantly affect the improvement of the TIE, the intensity of R&D has a significantly negative impact on the TIE, a higher level of R&D personnel in the HTI can be helpful in improving TIE, and increasing the import and export trade volumes of the HTI can promote TIE.
Role of NF-κB in Platelet Function
Authors: Kojok Kevin , El-Kadiry Abed El-Hakim , Merhi Yahye
Published: August 2019

Platelets are megakaryocyte-derived fragments lacking nuclei and prepped to maintain primary hemostasis by initiating blood clots on injured vascular endothelia. Pathologically, platelets undergo the same physiological processes of activation, secretion, and aggregation yet with such pronouncedness that they orchestrate and make headway the progression of atherothrombotic diseases not only through clot formation but also via forcing a pro-inflammatory state. Indeed, nuclear factor-κB (NF-κB) is largely implicated in atherosclerosis and its pathological complication in atherothrombotic diseases due to its transcriptional role in maintaining pro-survival and pro-inflammatory states in vascular and blood cells. On the other hand, we know little on the functions of platelet NF-κB, which seems to function in other non-genomic ways to modulate atherothrombosis. Therein, this review will resemble a rich portfolio for NF-κB in platelets, specifically showing its implications at the levels of platelet survival and function. We will also share the knowledge thus far on the effects of active ingredients on NF-κB in general, as an extrapolative method to highlight the potential therapeutic targeting of NF-κB in coronary diseases. Finally, we will unzip a new horizon on a possible extra-platelet role of platelet NF-κB, which will better expand our knowledge on the etiology and pathophysiology of atherothrombosis.
Homology Modeling-Based in Silico Affinity Maturation Improves the Affinity of a Nanobody
Authors: Cheng Xin , Wang Jiewen , Kang Guangbo , Hu Min , Yuan Bo , Zhang Yingtian , Huang He
Published: August 2019

Affinity maturation and rational design have a raised importance in the application of nanobody (VHH), and its unique structure guaranteed these processes quickly done in vitro. An anti-CD47 nanobody, Nb02, was screened via a synthetic phage display library with 278 nM of KD value. In this study, a new strategy based on homology modeling and Rational Mutation Hotspots Design Protocol (RMHDP) was presented for building a fast and efficient platform for nanobody affinity maturation. A three-dimensional analytical structural model of Nb02 was constructed and then docked with the antigen, the CD47 extracellular domain (CD47ext). Mutants with high binding affinity are predicted by the scoring of nanobody-antigen complexes based on molecular dynamics trajectories and simulation. Ultimately, an improved mutant with an 87.4-fold affinity (3.2 nM) and 7.36 °C higher thermal stability was obtained. These findings might contribute to computational affinity maturation of nanobodies via homology modeling using the recent advancements in computational power. The add-in of aromatic residues which formed aromatic-aromatic interaction plays a pivotal role in affinity and thermostability improvement. In a word, the methods used in this study might provide a reference for rapid and efficient in vitro affinity maturation of nanobodies.
Hypoxic Regulation of Neutrophils in Cancer
Authors: Triner Daniel , Shah Yatrik M.
Published: August 2019

Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating neutrophil function in tumors. Furthermore, neutrophil-specific expression of hypoxia-inducible transcription factors may represent a novel therapeutic target for human cancer. In this review, we highlight the function of neutrophils in cancer and the role of the neutrophil hypoxic response in regulating the neoplastic progression of cancer.
The Role of Fibroblast Growth Factor 23 in Inflammation and Anemia
Authors: Czaya Brian , Faul Christian
Published: August 2019

In patients with chronic kidney disease (CKD), adverse outcomes such as systemic inflammation and anemia are contributing pathologies which increase the risks for cardiovascular mortality. Amongst these complications, abnormalities in mineral metabolism and the metabolic milieu are associated with chronic inflammation and iron dysregulation, and fibroblast growth factor 23 (FGF23) is a risk factor in this context. FGF23 is a bone-derived hormone that is essential for regulating vitamin D and phosphate homeostasis. In the early stages of CKD, serum FGF23 levels rise 1000-fold above normal values in an attempt to maintain normal phosphate levels. Despite this compensatory action, clinical CKD studies have demonstrated powerful and dose-dependent associations between FGF23 levels and higher risks for mortality. A prospective pathomechanism coupling elevated serum FGF23 levels with CKD-associated anemia and cardiovascular injury is its strong association with chronic inflammation. In this review, we will examine the current experimental and clinical evidence regarding the role of FGF23 in renal physiology as well as in the pathophysiology of CKD with an emphasis on chronic inflammation and anemia.
Mechanistic Insights into Arbuscular Mycorrhizal Fungi-Mediated Drought Stress Tolerance in Plants
Authors: Bahadur Ali , Batool Asfa , Nasir Fahad , Jiang Shengjin , Mingsen Qin , Zhang Qi , Pan Jianbin , Liu Yongjun , Feng Huyuan
Published: August 2019

Arbuscular mycorrhizal fungi (AMF) establish symbiotic interaction with 80% of known land plants. It has a pronounced impact on plant growth, water absorption, mineral nutrition, and protection from abiotic stresses. Plants are very dynamic systems having great adaptability under continuously changing drying conditions. In this regard, the function of AMF as a biological tool for improving plant drought stress tolerance and phenotypic plasticity, in terms of establishing mutualistic associations, seems an innovative approach towards sustainable agriculture. However, a better understanding of these complex interconnected signaling pathways and AMF-mediated mechanisms that regulate the drought tolerance in plants will enhance its potential application as an innovative approach in environmentally friendly agriculture. This paper reviews the underlying mechanisms that are confidently linked with plant–AMF interaction in alleviating drought stress, constructing emphasis on phytohormones and signaling molecules and their interaction with biochemical, and physiological processes to maintain the homeostasis of nutrient and water cycling and plant growth performance. Likewise, the paper will analyze how the AMF symbiosis helps the plant to overcome the deleterious effects of stress is also evaluated. Finally, we review how interactions between various signaling mechanisms governed by AMF symbiosis modulate different physiological responses to improve drought tolerance. Understanding the AMF-mediated mechanisms that are important for regulating the establishment of the mycorrhizal association and the plant protective responses towards unfavorable conditions will open new approaches to exploit AMF as a bioprotective tool against drought.
Duchenne Muscular Dystrophy Newborn Screening: Evaluation of a New GSP® Neonatal Creatine Kinase-MM Kit in a US and Danish Population
Authors: Timonen Anne , Lloyd-Puryear Michele , Hougaard David M. , Meriö Liisa , Mäkinen Pauliina , Laitala Ville , Pölönen Tuukka , Skogstrand Kristin , Kennedy Annie , Airenne Sari , Polari Hanna , Korpimäki Teemu
Published: August 2019

Duchenne muscular dystrophy (DMD/Duchenne) is a progressive X-linked disease and is the most common pediatric-onset form of muscular dystrophy, affecting approximately 1:5000 live male births. DNA testing for mutations in the dystrophin gene confirms the diagnosis of this disorder. This study involves assessment of screening newborns for DMD using an immunoassay for muscle-type (MM) creatine kinase (CK) isoform—the GSP Neonatal CK-MM kit. Comparisons were made with CK activity determination by fluorescence measurement. In addition, the study evaluated the effect of gestational age, age of infant at time of sampling and how stable the CK-MM was over time. This assay discriminates well between normal, unaffected and Duchenne affected populations and is suitable for Duchenne newborn screening.
Emigration Effects Induced by Radio Frequency Treatment to Dates Infested by Carpophilus hemipterus
Authors: Rosi Marzia Cristiana , Garbati Pegna Francesco , Nencioni Anita , Guidi Roberto , Bicego Michele , Belcari Antonio , Sacchetti Patrizia
Published: August 2019

The dried fruit beetle (Carpophilus hemipterus) is considered a key pest of dates, infesting fruits both in the field and during storage. Control measures against the species rely on the use of chemicals or heat treatments based on sunlight, hot air or radio frequency (RF) applications. Previous investigations that have aimed to define control procedures for a total disinfestation using RF treatments with different exposure durations have shown the typical behavior of adults in some trials, which, under the influence of temperature increases, started to escape from infested fruits. We focused on the application of different RF voltage-time combinations to induce the emigration of C. hemipterus adults from dates in order to produce a complete disinfestation. The results showed that the application of 2500 V RF for 8–10 min to infested dates resulted in nearly 100% of adults escaping from fruits, thereby cleaning the commodity with low or no mortality inside and outside the dates. These achievements provide a new strategy for controlling key insect pests of dates that could be applied at an industrial scale, allowing for the quick disinfestation of fruits without affecting the fruit with harmful substances, such as residues from chemical treatments, and without unwanted side effects on date quality.
Raman Spectroscopy Analysis for Optical Diagnosis of Oral Cancer Detection
Authors: Jeng Ming-Jer , Sharma Mukta , Sharma Lokesh , Chao Ting-Yu , Huang Shiang-Fu , Chang Liann-Be , Wu Shih-Lin , Chow Lee
Published: August 2019

Raman spectroscopy (RS) is widely used as a non-invasive technique in screening for the diagnosis of oral cancer. The potential of this optical technique for several biomedical applications has been proved. This work studies the efficacy of RS in detecting oral cancer using sub-site-wise differentiation. A total of 80 samples (44 tumor and 36 normal) were cryopreserved from three different sub-sites: The tongue, the buccal mucosa, and the gingiva of the oral mucosa during surgery. Linear discriminant analysis (LDA) and quadratic discriminant analysis (QDA) were used with principal component analysis (PCA) to classify the samples and the classifications were validated by leave-one-out-cross-validation (LOOCV) and k-fold cross-validation methods. The normal and tumor tissues were differentiated under the PCA-LDA model with an accuracy of 81.25% (sensitivity: 77.27%, specificity: 86.11%). The PCA-QDA classifier model differentiated these tissues with an accuracy of 87.5% (sensitivity: 90.90%, specificity: 83.33%). The PCA-QDA classifier model outperformed the PCA-LDA-based classifier. The model studies revealed that protein, amino acid, and beta-carotene variations are the main biomolecular difference markers for detecting oral cancer.
A Randomized Comparison between 4, 6 and 8 mL of Local Anesthetic for Ultrasound-Guided Stellate Ganglion Block
Authors: Yoo Yongjae , Lee Chang-soon , Kim Yong-Chul , Moon Jee Youn , Finlayson Roderick J.
Published: August 2019

Background: Because it affords greater accuracy than landmark-based techniques, ultrasound guidance may reduce the volume of local anesthetic required for sympathetic blockade of the upper extremity. We hypothesized that 4 mL would provide a similar clinical effect when compared to larger volumes. Methods: One hundred and two patients with chronic neuropathic pain of the upper extremity or face were randomly assigned to receive an ultrasound-guided (USG) stellate ganglion block (SGB) with either 4 mL (group A), 6 mL (group B) or 8 mL (group C) mL of 1.0% lidocaine. Skin temperatures of the face, hand, and axillary fold were measured bilaterally at baseline, 10, 20, and 30 min after the block. Our primary outcome was the relative increase in hand temperature on the blocked side at 30 min and our non-inferiority margin was −0.6 °C. Secondary outcomes included success rate (as defined by a relative temperature increase of ≥1.5 °C), pain relief, degree of ptosis and side-effects. Results: The 95% confidence intervals for the difference of the means exceeded our non-inferiority margin (A versus B: −0.76 to 0.24; A versus C: −0.89 to 0.11) for temperature changes in the hand; however, success rates were similar (44, 45 and 55% for A, B and C respectively, p = 0.651). No intergroup differences were found in temperature-related outcomes for the other measurement sites (face, axilla). The incidence of minor side-effects was significantly higher in group C and no block-related complications were noted. Conclusions: We were unable to establish the non-inferiority of a 4 mL volume for sympathetic blockade of the hand. The clinical significance of these findings is unclear as success rates were similar between the different groups. In contrast, the 6- and 8 mL volumes were not associated with greater temperature changes in the face and axilla.
Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
Authors: Grasl Stefan , Janik Stefan , Grasl Matthaeus C. , Pammer Johannes , Formanek Michael , Weinreb Ilan , Perez-Ordonez Bayardo , Hope Andrew , Hosni Ali , de Almeida John R. , Irish Jon , Gilbert Ralph , Goldstein David P. , Erovic Boban M.
Published: August 2019

The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (p = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69–44.01; p = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01–0.37; p = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02–0.59; p = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.
Dietary Nutrient Intake, Alcohol Metabolism, and Hangover Severity
Authors: Verster Joris C. , Vermeulen Sterre A. , van de Loo Aurora J. A. E. , Balikji Stephanie , Kraneveld Aletta D. , Garssen Johan , Scholey Andrew
Published: August 2019

Several dietary components have been shown to influence alcohol metabolism and thereby potentially affect the development of a hangover. From the literature, it is evident that dietary nicotinic acid and zinc play a pivotal role in the oxidation of ethanol into acetaldehyde. The aim of the current study was to associate dietary intake of nicotinic acid and zinc with hangover severity. To this end, data from n = 23 healthy social drinkers who participated in a naturalistic hangover study were analyzed. n = 10 of them reported to be hangover-resistant (the control group), whereas n = 13 reported to have regular hangovers (the hangover-sensitive group). Two 24 h dietary recall records were completed, one for the day of alcohol consumption and another one for an alcohol-free control day. Dietary nutrient intake was averaged and did not significantly differ between hangover-sensitive and hangover-resistant drinkers. For the hangover-sensitive drinkers, partial correlations with overall hangover severity were computed, controlling for estimated blood alcohol concentration. A bootstrapping technique was applied to account for the relatively small sample size. The results showed that dietary intake of nicotinic acid (rPB = −0.521) and zinc (rPB = −0.341) were significantly and negatively associated (p < 0.002) with overall hangover severity. Dietary zinc intake was also significantly and negatively associated with severity of vomiting (rPB = −0.577, p < 0.002). No significant associations with hangover severity were found for other nutrients, such as fat and fibers. In conclusion, this study suggests that social drinkers who have a higher dietary intake of nicotinic acid and zinc report significantly less severe hangovers. As hangover-resistant and hangover-sensitive drinkers had a similar dietary nutrient intake, the claim of being hangover-resistant must be based on other unknown biopsychosocial factors. These findings should be replicated in a larger sample and include more elaborate food frequency questionnaires or nutrient-specific dietary intake records for zinc and nicotinic acid, and preferably accompanied by nutrient assessments in urine and/or blood.
Alcohol Hangover Slightly Impairs Response Selection but not Response Inhibition
Authors: Opitz Antje , Hubert Jan , Beste Christian , Stock Ann-Kathrin
Published: August 2019

Alcohol hangover commonly occurs after an episode of heavy drinking. It has previously been demonstrated that acute high-dose alcohol intoxication reduces cognitive control, while automatic processes remain comparatively unaffected. However, it has remained unclear whether alcohol hangover, as a consequence of binge drinking, modulates the interplay between cognitive control and automaticity in a comparable way. Therefore, the purpose of this study was to investigate the effects of alcohol hangover on controlled versus automatic response selection and inhibition. N = 34 healthy young men completed a Simon Nogo task, once sober and once hungover. Hangover symptoms were experimentally induced by a standardized administration of alcoholic drinks (with high congener content) on the night before the hangover appointment. We found no significant hangover effects, which suggests that alcohol hangover did not produce the same functional deficits as an acute high-dose intoxication. Yet still, add-on Bayesian analyses revealed that hangover slightly impaired response selection, but not response inhibition. This pattern of effects cannot be explained with the current knowledge on how ethanol and its metabolite acetaldehyde may modulate response selection and inhibition via the dopaminergic or GABAergic system.
Vitamin D Deficiency is Associated with Increased Disease Activity in Patients with Inflammatory Bowel Disease
Authors: Hausmann Johannes , Kubesch Alica , Amiri Mana , Filmann Natalie , Blumenstein Irina
Published: August 2019

Background and Aims: Vitamin D has an inhibitory role in the inflammatory signaling pathways and supports the integrity of the intestinal barrier. Due to its immunomodulatory effect, vitamin D plays a role in chronic inflammatory bowel disease (IBD) and a deficiency is associated with an increased risk for a flare. We aimed to investigate to what extent the 25-hydroxyvitamin D (25(OH)D3) level correlates with disease activity and whether a cut-off value can be defined that discriminates between active disease and remission. Methods: Patients with IBD, treated at the University Hospital Frankfurt were analyzed retrospectively. The 25(OH)D3 levels were correlated with clinical activity indices and laboratory chemical activity parameters. A deficiency was defined as 25(OH)D3 levels <30 ng/mL. Results: A total of 470 (257 female) patients with IBD were included, 272 (57.9%) with Crohn’s disease (CD), 198 (42.1%) with ulcerative colitis (UC). The median age of the patients was 41 (18–84). In 283 patients (60.2%), a vitamin D deficiency was detected. 245 (53.6%) patients received oral vitamin D supplementation, and supplemented patients had significantly higher vitamin D levels (p < 0.0001). Remission, vitamin D substitution, and male gender were independently associated with the 25(OH)D3 serum concentration in our cohort in regression analysis. A 25(OH)D3 serum concentration of 27.5 ng/mL was the optimal cut-off value. Conclusion: Vitamin D deficiency is common in IBD patients and appears to be associated with increased disease activity. In our study, vitamin D levels were inversely associated with disease activity. Thus, close monitoring should be established, and optimized supplementation should take place.
Integrins Have Cell-Type-Specific Roles in the Development of Motor Neuron Connectivity
Authors: Oliver Devyn , Norman Emily , Bates Heather , Avard Rachel , Rettler Monika , Bénard Claire Y. , Francis Michael M. , Lemons Michele L.
Published: August 2019

Formation of the nervous system requires a complex series of events including proper extension and guidance of neuronal axons and dendrites. Here we investigate the requirement for integrins, a class of transmembrane cell adhesion receptors, in regulating these processes across classes of C. elegans motor neurons. We show α integrin/ina-1 is expressed by both GABAergic and cholinergic motor neurons. Despite this, our analysis of hypomorphic ina-1(gm144) mutants indicates preferential involvement of α integrin/ina-1 in GABAergic commissural development, without obvious involvement in cholinergic commissural development. The defects in GABAergic commissures of ina-1(gm144) mutants included both premature termination and guidance errors and were reversed by expression of wild type ina-1 under control of the native ina-1 promoter. Our results also show that α integrin/ina-1 is important for proper outgrowth and guidance of commissures from both embryonic and post-embryonic born GABAergic motor neurons, indicating an ongoing requirement for integrin through two phases of GABAergic neuron development. Our findings provide insights into neuron-specific roles for integrin that would not be predicted based solely upon expression analysis.
Gifted and Average-Ability Children’s Potential for Solving Analogy Items
Authors: Vogelaar Bart , Sweijen Sophie W. , Resing Wilma C. M.
Published: August 2019

Analogical reasoning is assumed to play a large role in learning and problem solving in everyday and school settings. It was examined whether a newly developed dynamic test of analogical reasoning would be sufficiently difficult for identifying young gifted children’s potential for solving analogies. The study included 74 gifted (n = 31) and average-ability (n = 43) children between 7 and 8 years old. Employing a pre-test–training–post-test format, in which half of the children received a graduated prompts training and the other half received a control task between pre-test and post-test, it was investigated (1) whether trained children would improve more in accuracy from pre-test to post-test than their untrained peers, and whether (2) gifted and average-ability children would demonstrate differences in their level of improvement from pre-test to post-test, and (3) their needs for instruction during training. The results indicated that dynamically tested children improved more than those in the control condition. In addition, the dynamic test seemed sufficiently difficult for the gifted children: regardless of whether they were trained, gifted children demonstrated superior accuracy scores than their average-ability agemates at pre-test and post-test, but similar levels of improvement. They were also found to need fewer instructions during training.
Assessing the Performance of Green Mines via a Hesitant Fuzzy ORESTE–QUALIFLEX Method
Authors: Liang Weizhang , Dai Bing , Zhao Guoyan , Wu Hao
Published: August 2019

Due to various environmental issues caused by resource exploitation, establishing green mines is an essential measure to realize sustainable growth for mining companies. This research aimed to develop a novel methodology to evaluate the performance of green mines within hesitant fuzzy conditions. First, hesitant fuzzy sets (HFSs) were used to express original fuzzy assessment values. Then, the extended expert grading approach and the modified maximum deviation method with HFNs were combined to determine comprehensive importance degrees of criteria. Afterward, the traditional qualitative flexible (QUALIFLEX) method was integrated with the Organísation, rangement et synthèse de données relationnelles (ORESTE) model to achieve the rankings of mines. Finally, the proposed hesitant fuzzy ORESTE–QUALIFLEX approach was utilized to evaluate the performance of green mines. In addition, the robustness of the method was verified by a sensitivity analysis, while the effectiveness and strengths were certified by a comparison analysis. The results indicate that the proposed methodology has great robustness and advantages and that it is feasible and effective for the performance evaluation of green mines under hesitant fuzzy environment.
Recombinant N-acyl homoserine lactone-Lactonase AiiAQSI-1 Attenuates Aeromonas hydrophila Virulence Factors, Biofilm Formation and Reduces Mortality in Crucian Carp
Authors: Zhang Bao , Zhuang Xiyi , Guo Liyun , McLean Robert J. C. , Chu Weihua
Published: August 2019

Quorum quenching (QQ) is a promising alternative infection-control strategy to antibiotics that controls quorum-regulated virulence without killing the pathogens. Aeromonas hydrophila is an opportunistic gram-negative pathogen living in freshwater and marine environments. A. hydrophila possesses an N-acyl homoserine lactone (AHL)-based quorum-sensing (QS) system that regulates virulence, so quorum signal-inactivation (i.e., QQ) may represent a new way to combat A. hydrophila infection. In this study, an AHL lactonase gene, aiiA was cloned from Bacillus sp. strain QSI-1 and expressed in Escherichia coli strain BL21(DE3). The A. hydrophila hexanoyl homoserine lactone (C6-HSL) QS signal molecule was degraded by AiiAQSI-1, which resulted in a decrease of bacterial swimming motility, reduction of extracellular protease and hemolysin virulence factors, and inhibited the biofilm formation of A. hydrophila YJ-1 in a microtiter assay. In cell culture studies, AiiAQSI-1 decreased the ability of A. hydrophila adherence to and internalization by Epithelioma papulosum cyprini (EPC) cells. During in vivo studies, oral administration of AiiAQSI-1 via feed supplementation attenuated A. hydrophila infection in Crucian Carp. Results from this work indicate that feed supplementation with AiiAQSI-1 protein has potential to control A. hydrophila aquaculture disease via QQ.
Design and Synthesis of Anti-Cancer Chimera Molecules Based on Marine Natural Products
Authors: Ha Min Woo , Song Bo Reum , Chung Hye Jin , Paek Seung-Mann
Published: August 2019

In this paper, the chemical conjugation of marine natural products with other bioactive molecules for developing an advanced anti-cancer agent is described. Structural complexity and the extraordinary biological features of marine natural products have led to tremendous research in isolation, structural elucidation, synthesis, and pharmacological evaluation. In addition, this basic scientific achievement has made it possible to hybridize two or more biologically important skeletons into a single compound. The hybridization strategy has been used to identify further opportunities to overcome certain limitations, such as structural complexity, scarcity problems, poor solubility, severe toxicity, and weak potency of marine natural products for advanced development in drug discovery. Further, well-designed marine chimera molecules can function as a platform for target discovery or degradation. In this review, the design, synthesis, and biological evaluation of recent marine chimera molecules are presented.
Blend Hybrid Solid Electrolytes Based on LiTFSI Doped Silica-Polyethylene Oxide for Lithium-Ion Batteries
Authors: Mosa Jadra , Vélez Jonh Fredy , Aparicio Mario
Published: August 2019

Organic/inorganic hybrid membranes that are based on GTT (GPTMS-TMES-TPTE) system while using 3-Glycidoxypropyl-trimethoxysilane (GPTMS), Trimethyletoxisilane (TMES), and Trimethylolpropane triglycidyl ether (TPTE) as precursors have been obtained while using a combination of organic polymerization and sol-gel synthesis to be used as electrolytes in Li-ion batteries. Self-supported materials and thin-films solid hybrid electrolytes that were doped with Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) were prepared. The hybrid network is based on highly cross-linked structures with high ionic conductivity. The dependency of the crosslinked hybrid structure and polymerization grade on ionic conductivity is studied. Ionic conductivity depends on triepoxy precursor (TPTE) and the accessibility of Li ions in the organic network, reaching a maximum ionic conductivity of 1.3 × 10−4 and 1.4 × 10−3 S cm−1 at room temperature and 60 °C, respectively. A wide electrochemical stability window in the range of 1.5–5 V facilitates its use as solid electrolytes in next-generation of Li-ion batteries.
A Methodology to Evaluate the Reliability Impact of the Replacement of Welded Components by Additive Manufacturing Spare Parts
Authors: Coro Armando , Macareno Luis María , Aguirrebeitia Josu , López de Lacalle Luis Norberto
Published: August 2019

This article shows a method for inspection scheduling of structures made by additive manufacturing, derived from reliability function evaluations and overhaul inspection findings. The routine was an adaption of an existing method developed by the authors for welded components; in this latter case, the routine used a stochastic defect-propagation analysis for pores and lack of fusion defects of additive manufacturing process, instead of the weld liquation crack. In addition, the authors modified the specific stress-intensity factor for welded components to consider additive manufacturing-related material property variability, defect distributions, flaw-inspection capabilities, and component geometry. The proposed routine evaluated the failure rate and inspection intervals using the first-order reliability method (FORM + Fracture) to alleviate the computational cost of probabilistic defect-propagation analysis. The proposed method is one of the first applying reliability concepts to additive manufacturing (AM) components. This is an important milestone, since in 10 years, additive manufacturing is to be used for 30% of the components in aeroengines. This paper presents an example comparing the reliability and cost of a jet engine, with components either made by additive manufacturing or welded parts; in the process, the reliability AM-key features are found, and overhaul schedules of an airplane fleet made with AM components are defined. The simplicity and performance demonstrated in the comparison make the proposed method a powerful engineering tool for additive manufacturing assessment in aeronautics.
Green Activated Magnetic Graphitic Carbon Oxide and Its Application for Hazardous Water Pollutants Removal
Authors: Lingamdinne Lakshmi Prasanna , Choi Jong-Soo , Choi Yu-Lim , Yang Jae-Kyu , Koduru Janardhan Reddy , Chang Yoon-Young
Published: August 2019

Graphitic carbon oxide (GCO) and magnetic graphitic carbon oxide (MGCO) were prepared from sugar via optimized green activation by employing ozone oxidation, and applied to wastewater treatment. The maximal oxidation and adsorption yield of pollutants were achieved at pH 2.0−4.0, which is the optimized pH for ozone oxidation of GC to generate GCO. As-prepared GCO and MGCO were characterized using X-ray, infrared, and microscopic techniques. The MGCO has enough saturation magnetization (MS) of 41.38 emu g−1 for separation of the sorbent from the reaction medium by applying an external magnetic field. Batch adsorption of radioactive and heavy metals (Th(IV), Pb(II)), and a dye (methylene blue (MB)) using GCO and MGCO was evaluated by varying the adsorbent dose, equilibrium pH, contact time, initial metal and dye concentrations, and kinetics and isotherms. Adsorption kinetics and isotherm studies indicated that Th(IV), Pb(II), and MB adsorption were best described by pseudo-second-order kinetics and Langmuir isotherm with R2 (correlation coefficient) > 0.99, respectively. The maximum adsorption capacities for Th(IV), Pb(II), and MB were 52.63, 47.39, and 111.12 mg g−1 on GCO and 76.02, 71.94, and 76.92 mg g−1 on MGCO. GCO and MGCO are prospectively effective and low-cost adsorbents for ion removal in wastewater treatment. As prepared MGCO can be reused up to three cycles for Th(IV), Pb(II), and MB. This work provides fundamental information about the equilibrium adsorption isotherms and mechanisms for Th(IV), Pb(II), and MB on GCO and MGCO.