bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Investigation on the Microstructural Properties of Black Cotton Soil Stabilized with Cinder (Scoria) Fines and Class-C Fly Ash
Authors: Ayehutsega Biruk , Assefa Eleyas , Sachpazis Costas
Published: October 2021

Black cotton soil is one of the significant problematic soil for any civil or geotechnical engineering application in the whole world. In the past several decades, different experimental studies have been carried out on the stabilization of expansive soil and different types of stabilizers like lime, Portland cement, cement fly ash, and lime fly ash were used and applied in highway and others construction. However, those traditional stabilizers are not environmentally friendly thus further scientific study is needed to minimize the percentage of carbon-based stabilizers. The fact that Ethiopia encountered major engineering problems due to these problematic soils many researchers have been conducted a vital study using traditional stabilizers for several years however there is no significant study on the microstructural properties of stabilized black cotton soil. In this study, a scoria fines and class c fly ash are used at different blended groups, for each group, the stabilizer content ranges from 10 to 30%. The liquid limit and plasticity index of the soil has been decreased with the increasing content of class c fly ash (FA) and cinder fines (CF). Especially after the soil treated with 25% of class c fly ash and 25% of cinder fines, the liquid limit has decreased by 51.61% and, the plasticity index by 78.61%, linear shrinkage by 66.58%, and the free swell index decreased by 78.9%. The CBR and UCS value has increased by 86.2% and 83.9%, respectively, and CBR swell reduced by 61.2% with increasing stabilizer content. The microstructural properties of Raw black cotton soil and samples that are selected based on strength and index properties (BCS+FA3, BCS+CF3, BCS+CF+FA3) were observed by Scanning electron microscopy (SEM) imagining device, and the result clearly shows the alteration in fabric and morphology of the sample. After treatment with class c fly ash and cinder fines, the laminated configuration of black cotton soil has changed to more flocculated and coherent mass. Also, the SEM image proves that cinder fines impart a mechanical bonding that forms well-developed floccules and a more porous nature. These types of particle arrangement and clay aggregation bring the improvement in index and strength properties.
Low Diagnostic Accuracy and Inter-Observer Agreement on CT and MRI in Diagnosis of Spinal Fractures in Multiple Myeloma
Authors: Dalen Viktor , Vegsgaard Olsen Anne-Sofie , Jerome Claude-Pierre , Geitung Jonn-Terje , Dahm Anders E. A.
Published: October 2021

Skeletal disease is common in multiple myeloma. We investigated the inter-observer agreement and diagnostic accuracy of spinal fractures diagnosed by computer tomography (CT) and magnetic resonance imaging (MRI) from 12 myeloma patients. Two radiologists independently assessed the images. CT, MRI, and other images were combined to a gold standard. The inter-observer agreement was assessed with Cohen’s kappa. Radiologist 1 diagnosed 20 malignant spinal fractures on CT and 26 on MRI, while radiologist 2 diagnosed 12 malignant spinal fractures on CT and 22 on MRI. In comparison the gold standard diagnosed 10 malignant spinal fractures. The sensitivity for malignant fractures varied from 0.5 to 1 for CT and MRI, and the specificity varied from 0.17 to 0.67. On MRI, the specificity for malignant spinal fractures was 0.17 for both radiologists. The inter-observer agreement for malignant spinal fractures on CT was −0.42 (Cohen’s kappa) and −0.13 for MRI, while for osteoporotic fractures it was −0.24 for CT and 0.53 for MRI. We conclude that malignant spinal fractures were over-diagnosed on CT and MRI. The inter-observer agreement was extremely poor.
Anti-angiogenic peptides application in cancer therapy; a review
Authors: Shoari Alireza , Khodabakhsh Farnaz , Ahangari Cohan Reza , Salimian Morteza , Karami Elmira
Published: October 2021

Cancer is a disease advanced via surplus angiogenesis. The development of new anti-angiogenic therapeutic agents with more efficacy and fewer side effects is still quite necessary. Conventional therapies saving the life of many cancer patients but due to drug resistance and lack of specificity utilizing these methods is faced with limits. Recently, new therapeutic agents have been developed and used to treat cancers such as scaffold proteins, monoclonal antibodies, tyrosine kinase inhibitors, and peptides. In antiangiogenic drug development, anti-angiogenic peptides design is a significant aim. Peptides have developed as substantial therapeutics that are being carefully investigated in angiogenesis-dependent diseases because of their high penetrating rate into the cancer cells, high specificity, and low toxicity. In this review, we focus on anti-angiogenic peptides in the field of cancer therapy that are designed, screened, or derived from nanobodies, mimotopes, phage displays, and natural resources.
QSAR analysis of pyrimidine derivatives as VEGFR-2 receptor inhibitors to inhibit cancer using multiple linear regression and artificial neural network
Authors: Masoomi Sefiddashti Fariba , Asadpour Saeid , Haddadi Hedayat , Ghanavati Nasab Shima
Published: October 2021

Background and purpose:

In this study, the pharmacological activity of 33 compounds of furopyrimidine and thienopyrimidine as vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitors to inhibit cancer was investigated. The most important angiogenesis inducer is VEGF endothelial growth factor, which exerts its activity by binding to two tyrosine kinase receptors called VEGFR-1 and VEGFR-2. Due to the critical role of VEGF in the pathological angiogenesis of this molecule, it is a valuable therapeutic target for anti-angiogenesis therapies.

Experimental approach:

After calculating descriptors using SPSS software and stepwise selection method, 5 descriptors were used for modeling in multiple linear regression (MLR) and artificial neural network (ANN). The calibration series and the test series in this study included 26 and 7 combinations, respectively.

Findings/Results:

The performance evaluation of models was determined by the R2, RMSE, and Q2 statistic parameters. The R2 values of MLR and ANN models were 0.889 and 0.998, respectively. Also, the value of RMSE in the ANN model was lower and its Q2 value was higher than the MLR model.

Conclusion and implications:

The results were evaluated by different statistical methods and it was concluded that the nonlinear neural network method is powerful to predict the pharmacological activity of similar compounds, and because of the complex and nonlinear relationships, the MLR was not capable of establishing a good model with high predictive power.
Galectin-9 inhibits cell proliferation and induces apoptosis in Jurkat and KE-37 acute lymphoblastic leukemia cell lines via caspase-3 activation
Authors: Zargar Balajam Narges , Shabani Mahdi , Aghaei Mahmoud
Published: October 2021

Background and purpose:

Acute lymphoblastic leukemia (ALL) is a type of cancer of blood and bone marrow characterized by abnormal proliferation of lymphoid progenitor cells. Galectin-9 is a tandem-repeat type galectin expressed in various tumor cells. It seems that the connection between galectin-9 and T cell immunoglobulin mucin-3 receptor acts as a negative regulator of cancer cells proliferation.

Experimental approach:

In this research, the effects of galectin-9 were investigated using MTS cell proliferation colorimetric, colony-forming, annexin V-FITC/PI, and caspase-3 assays in the Jurkat and KE-37 cell lines of ALL. Furthermore, the western blotting technique was used to evaluate the levels of apoptotic proteins such as Bax and Bcl-2 in these cell lines.

Findings/Results:

Our results indicated that galectin-9 can considerably reduce the cell growth and colony formation ability of both Jurkat and KE-37 cell lines in a concentration-dependent manner. Besides, galectin-9 induced apoptosis in a concentration-dependent manner in ALL cells by a mechanism associated with Bax/Bcl-2 expression and activation of the caspase-3 activation.

Conclusion and implications:

Galectin-9 inhibited the growth and proliferation of cell lines with increased programmed cell death, therefore it can be considered as a potential factor in the progression of ALL therapeutics that needs more research in this context.
Synthesis and cytotoxic activity evaluation of some new 1, 3, 4-oxadiazole, 1, 3, 4-thiadiazole and 1, 2, 4- triazole derivatives attached to phthalimide
Authors: Hassanzadeh Farshid , Jafari Elham , Shojaei Faezeh , Sadeghi-Aliabadi Hojjat
Published: October 2021

Background and purpose:

In the last few decades, nitrogen-rich heterocyclic compounds such as 1, 3, 4-thiadiazoles, 1, 2, 4-triazoles and 1, 3, 4-oxadiazoles have received considerable attention because of their notable biological properties, especially cytotoxic effects. The small molecules of mentioned azole derivatives revealed very intensive antitumor activity. In addition, phthalimide-thiadiazole and naphthalimide-triazole hybrid derivatives have shown remarkable cytotoxic effects. According to these observations, some of the hybrid derivatives containing the phthalimide-five-membered azoles were prepared in three steps in this research.

Experimental approach:

The thiol group of azoles was treated with ethyl chloroacetate which was followed by a reaction with hydrazine hydrate to provide acid hydrazide derivatives. Subsequently, the corresponding acid hydrazides were utilized to prepare the final derivatives through the reaction with phthalic anhydride. Cytotoxic activity of final compounds was evaluated against MCF-7 and HeLa cell lines using MTT assay.

Findings/Results:

Compound 3d containing two phthalimide moieties in its structure showed a significant improvement in cytotoxic activity with an IC50 value of 29 μM against HeLa cell line. Compounds 3a-3c showed less cytotoxic effects against both cell lines.

Conclusion and implications:

The combination of the thiadiazole nucleus with two phthalimide structures increased the cytotoxic activity against the HeLa cell line. This increase in cytotoxic activity is probably due to its being more lipophilic characteristic and interaction of this derivative with the biological targets of two directions.
Protective effects of hydroalcoholic extract of Stachys pilifera on paracetamol-induced nephrotoxicity in female rats
Authors: Rabani Mohammad Reza , Azarmehr Nahid , Moslemi Zahra , Sadeghi Heibatollah , Amini-Khoei Hossein , Doustimotlagh Amir Hossein
Published: October 2021

Background and purpose:

Stachys pilifera is used in traditional medicine due to its antioxidant, anti-inflammatory, and antimicrobial effects. The goal of this study was to examine the renoprotective activity of the hydroalcoholic extract of aerial parts of S. pilifera on paracetamol (PCM)-induced nephrotoxicity.

Experimental approach:

The Wistar female rats were randomly divided into four groups including control, PCM, S. pilifera hydroalcoholic extract (SPE), and PCM + SPE. The animals received SPE (500 mg/kg) for one week and PCM (3 g/kg) on the 6th day orally. Kidney function tests and oxidant/antioxidant markers were determined in serum and tissue homogenate, respectively. Protein and mRNA levels of TNF-α, as well as hematoxylin and eosin staining, were assessed in the kidney tissue.

Findings/Results:

Treatment with SPE in the PCM group significantly decreased blood urea nitrogen and creatinine against the merely PCM rats (P < 0.05). The amount of nitric oxide metabolite and superoxide dismutase activity in the group receiving SPE showed a significant increase compared to PCM rats (P < 0.05). A significant difference in TNF-α levels between the groups was not observed. Histological changes were improved in the rats treated with SPE.

Conclusion and implications:

Totally, our findings showed that SPE can inhibit PCM nephrotoxicity by enhancing kidney function markers, antioxidant status, and histological changes. Though, more researches are required to estimate the possible mechanism of SPE.
Perception of Faculty and Students about E-learning – Its Feasibility, Acceptance, and Implementation in COVID Pandemic Crisis
Authors: Menon Pramila , Pande Vineeta , Jadhav Sudhir , Agarkhedkar Sharad
Published: October 2021

Context:

The study aimed to understand the perception of faculty and undergraduate students toward E-learning and its acceptance and feasibility during the corona pandemic.

Aim:

It aimed at collecting suggestions to improve the teaching–learning process.

Settings and Design:

This was an online survey conducted using Google Forms.

Subjects and Methods:

Responses were sought from participants through Google Forms and their feedback was collected using a semi-structured questionnaire which had 14 items including demographic profile, platform used for online teaching–learning, advantages, comfort level, usefulness of platform, challenges faced, and suggestions for improvement.

Statistical Analysis Used:

Statistical Analysis was done by using IBM SPSS Statistics for Windows, Version 26.0.

Results:

Responses were sought from a total of 447 (436 + 11) participants through Google Forms. Out of 447 participants, 321 responses (71%; 95% confidence interval [CI]; 67.5–75.8) were recorded and their feedback was collected using a semi-structured questionnaire which had 14 items including demographic profile, platform used for online teaching–learning, advantages, comfort level, usefulness of platform, challenges faced, and suggestions for improvement. The response rate was 71.4%% (95% CI; 67.5–75.8). About 81% (95% CI; 67.5-75.8) of participants were happy with the ongoing online teaching–learning. About 52.9% (95% CI; 47.3–58.6) are using Google Classroom, 32.2% (95% CI; 27–37.6) are using video-based platforms such as Zoom, Google Meet, and Cisco Webex. About 53.6% (95% CI; 48–59.2) of participants viewed Google Classroom as the best platform, whereas 44.1% (95% CI; 38.5–49.7) favored video-based platforms for teaching–learning.

Conclusions:

Online classes were found acceptable by most of the students and faculty. The positive feedback and suggestions helped in the planning of E-learning classes in the existing curriculum for future.
Alteration of blood monocyte subsets in chronic rhinosinusitis with regard to anti-inflammatory 1,8-Cineol treatment
Authors: Polasky C. , Loyal K. , Idel C. , Wetterauer D. , Heidemann M. , Bruchhage K.L. , Pries R.
Published: October 2021

Background: Chronic rhinosinusitis (CRS) affects about 10% of the european population causing considerable disease burden. The inflammatory microenvironment is mainly Th2 driven, but the impact of monocytes is still poorly understood. Aim of this study was to comprehensively investigate the composition of circulating monocytes and T cells in CRSwNP and CRSsNP patients, particularly with regard to the therapeutic herbal monoterpene 1,8-Cineol. Methodology: We analyzed the distribution of CD14 and CD16 classified monocyte subsets and the T-cell subset composition with respect to their PD-1 and PD-L1 expression in the peripheral blood of CRS patients using flow cytometry. Additionally, the M1/M2 like macrophage infiltration in nasal tissue and polyps was examined by immunofluorescence staining. Results: Data revealed a decrease of classical monocytes accompanied by a significant increase of intermediate CD16+ monocytes in CRSwNP and CRSsNP patients compared to healthy donors. PD-L1 expression on overall monocytes was also significantly increased in CRSwNP and CRSsNP patients. CRS patients with a severe drop of the proportion of classical monocytes showed a significant restoration of this subset in response to two-week 1,8-Cineol treatment. Conclusions: Our data indicate a CRS-induced shift of peripheral monocyte subsets to more inflammatory phenotypes that might be reversed by the herbal drug 1,8-Cineol.
Implementing Serosurveys in India: Experiences, Lessons Learned, and Recommendations
Authors: Hasan Alvira Z. , Kumar Muthusamy Santhosh , Prosperi Christine , Thangaraj Jeromie Wesley Vivian , Sabarinathan R. , Saravanakumar V. , Duraiswamy Augustine , Kaduskar Ojas , Bhatt Vaishali , Deshpande Gururaj Rao , Ullas Padinjaremattathil Thankappan , Sapkal Gajanan N. , Sangal Lucky , Mehendale Sanjay M. , Gupta Nivedita , Moss William J. , Hayford Kyla , Murhekar Manoj V. , _ _
Published: October 2021

Serological surveillance for vaccine-preventable diseases, such as measles and rubella, can provide direct measures of population immunity across age groups, identify gaps in immunity, and document changes in immunity over time. Rigorously conducted, representative household serosurveys provide high-quality estimates with minimal bias. However, they can be logistically challenging, expensive, and have higher refusal rates than vaccine coverage surveys. This article shares lessons learned through implementing nine measles and rubella household serosurveys in five districts in India—the challenges faced, the potential impact on results, and recommendations to facilitate the conduct of serosurveys. Specific lessons learned arose from challenges related to community mobilization owing to lack of cooperation in certain settings and populations, limitations of outdated census information, nonresponse due to refusal or unavailability during survey enumeration and enrollment, data collection issues, and specimen collection and handling issues. Although some experiences are specific to serosurveys in India, these lessons are generalizable to other household surveys, particularly vaccination coverage and serosurveys conducted in low- and middle-income settings.
Health-Related Quality of Life of Tuberculosis Patients and the Role of Socioeconomic Factors: A Mixed-Method Study
Authors: Rafiq Muhammad , Saqib Shahab E. , Atiq Muhammad
Published: October 2021

This study aims to assess tuberculosis (TB) patients’ health-related quality of life (HRQoL) and to determine the relationship between HRQoL and the socioeconomic and health characteristics of patients. A mixed-method approach of explanatory sequential design is used in this study. Data were collected at 11 TB centers and two private clinics in Khyber Pakhtunkhwa, Pakistan. Quantitative data were collected through a standardized questionnaire (SF-36) of RAND organization from 269 pulmonary TB patients. Qualitative data were collected through 20 in-depth interviews, 15 Key Informant interviews, and a focus group discussion. The maximum score of SF-36 is 100, however, different aspects of HRQoL indicated that patients scored lowest in the role limitation physical (10.3) and emotional (11.2) categories, while the highest remained in the mental health (45.3) category. Patients of higher age, being female, low household income, and comorbidity decreased the HRQoL. Qualitative findings show that TB affected the patients’ social functioning, vitality, and emotions. Moreover, poverty and low income, people living in Kacha Houses, family support, and the hate from family members and community are related to low HRQoL. In summary, TB has affected the Patients’ HRQoL. TB program managers should pay attention to the nonmedication aspects of TB management. Financial support should be extended TB patients. This study calls for the urgent attention of the National Tuberculosis Program and policymakers, for an increased focus on patients’ welfare programs.
Prevalence of Dengue, Chikungunya, and Zika Viruses in Febrile Pregnant Women: An Observational Study at a Tertiary Care Hospital in North India
Authors: Gupta Akanksha , Jain Parul , Venkatesh Vimala , Agarwal Anjoo , Reddy D. Himanshu , Jain Amita
Published: October 2021

Dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) are arboviruses that can affect maternal and fetal outcome if acquired during pregnancy. This study was done to estimate the positivity of DENV, CHIKV, and ZIKV in febrile pregnant women attending a tertiary care hospital in north India. Symptomatic pregnant women were tested for these viruses by IgM ELISA and/or by Trioplex real-time polymerase chain reaction. Their symptoms and laboratory parameters were recorded and were followed up till delivery to know their immediate delivery outcome. Of 104 women tested, 50 (48.1%) were positive for viral markers. Of these, evidence of infection by DENV, CHIKV, and both was found in 34 (32.7%), 10 (9.6%), and 6 (5.8%), respectively. ZIKV was not detected in any woman. Maximum DENV positivity occurred in the third trimester of pregnancy and in women residing in urban than rural areas. Chills and rigors, arthralgia, retro-orbital pain, anemia, and vaginal bleeding were more commonly associated with DENV positivity. Backache, arthralgia, jaundice, and vaginal bleeding were more common in CHIKV positives but the difference between positives and nonpositives regarding these symptoms was not statistically significant. Dengue infections were associated with more frequent hospitalizations (OR = 8.38, 95% confidence intervals [CI] = 3.29–21.30) and mortality (OR = 19.0, 95% CI = 1.01–357.10). Hence, to conclude, in India wherever possible, all symptomatic pregnant women should be screened for DENV, CHIKV, and ZIKV as part of sentinel surveillance for ZIKV.
Local breeds and pastoral farming on the North Mediterranean shore: a univocal coevolution? An example of dairy sheep farming systems in Corsica (France) and Thessaly (Greece)
Authors: Perucho Lola , Hadjigeorgiou Ioannis , Lauvie Anne , Moulin Charles-Henri , Paoli Jean-Christophe , Ligda Christina
Published: October 2021

Using local resources for ruminant feeding is a way to achieve agroecological production in pastoral farming systems. In North Mediterranean countries, sheep farming systems have evolved towards more intensive systems in lowland and hilly areas, whereas remote and rough pastureland is abandoned and local breeds are rarely maintained; rather, they are progressively replaced by highly productive breeds and their crosses. Using the examples of Corsica (France) and Thessaly (Greece), two dairy sheep farming territories developing intensive farming systems that differ in the livestock breeds they use, we explored the hypothesis that the use of local breeds may not be systematically related to the maintenance of pastoral practices in Mediterranean dairy sheep farming systems. For this purpose, three data sets based on interviews with sheep farmers of local breeds and crossbred flocks were analysed in two study areas. The results demonstrated that local breeds’ adaptive abilities can be used in crossbred flocks or purebred flocks to maintain a feeding system based on pastoral components. However, other drivers also appear to lead into the declining use of local pastoral resources. Apart from the use of local breeds, year-to-year adjustments of replacement and culling rates sometimes have to be applied in order to address the inter-annual variations of the fodder on offer. This paper provides an original approach to studying the link between local breeds and the pastoral components of farming systems by combining synchronic and diachronic analyses of the practices in crossbred and purebred flocks composed of local breeds.
Foundations of regular coinduction
Authors: Dagnino Francesco
Published: October 2021

Inference systems are a widespread framework used to define possibly
recursive predicates by means of inference rules. They allow both inductive and
coinductive interpretations that are fairly well-studied. In this paper, we
consider a middle way interpretation, called regular, which combines advantages
of both approaches: it allows non-well-founded reasoning while being finite. We
show that the natural proof-theoretic definition of the regular interpretation,
based on regular trees, coincides with a rational fixed point. Then, we provide
an equivalent inductive characterization, which leads to an algorithm which
looks for a regular derivation of a judgment. Relying on these results, we
define proof techniques for regular reasoning: the regular coinduction
principle, to prove completeness, and an inductive technique to prove
soundness, based on the inductive characterization of the regular
interpretation. Finally, we show the regular approach can be smoothly extended
to inference systems with corules, a recently introduced, generalised
framework, which allows one to refine the coinductive interpretation, proving
that also this flexible regular interpretation admits an equivalent inductive
characterisation.
Novel Symmetric Numerical Methods for Solving Symmetric Mathematical Problems
Authors: Ibrahimov V. R. , Mehdiyeva G.Yu. , Yue Xiao-Guang , Kaabar Mohammed K.A. , Noeiaghdam Samad , Juraev Davron Aslonqulovich
Published: October 2021

The mathematical model for many problems is arising in different industries of natural science, basically formulated using differential, integral and integro-differential equations. The investigation of these equations is conducted with the help of numerical integration theory. It is commonly known that a class of problems can be solved by applying numerical integration. The construction of the quadrature formula has a direct relation with the computation of definite integrals. The theory of definite integrals is used in geometry, physics, mechanics and in other related subjects of science. In this work, the existence and uniqueness of the solution of above-mentioned equations are investigated. By this way, the domain has been defined in which the solution of these problems is equivalent. All proposed four problems can be solved using one and the same methods. We define some domains in which the solution of one of these problems is also the solution of the other problems. Some stable methods with the degree p<=8 are constructed to solve some problems, and obtained results are compared with other known methods. In addition, symmetric methods are constructed for comparing them with other well-known methods in some symmetric and asymmetric mathematical problems. Some of our constructed methods are compared with Gauss methods. In addition, symmetric methods are constructed for comparing them with other well-known methods in some symmetric and asymmetric mathematical problems. Some of our constructed methods are compared with Gauss methods. On the intersection of multistep and hybrid methods have been constructed multistep methods and have been proved that these methods are more exact than others. And also has been shown that, hybrid methods constructed here are more exact than Gauss methods. Noted that constructed here hybrid methods preserves the properties of the Gauss method.
Hastaneler İçin Diğer Binalara Göre Farklı Enerji Verimliliği Uygulamaları
Authors: YİLMAZOGLU Zeki
Published: October 2021

Bu çalışmada, hastaneler özelinde diğer bina tiplerinden farklı olan bazı enerji verimliliği uygulamaları ele alınmıştır. Hastaneler, diğer bina tiplerinden enerji tüketimi açısından farklı bir yapıya sahiptir. Enerji kullanım yoğunluğu yüksek olan bu bina tipinde özellikle tasarım ve işletme açısından farklı enerji verimliliği uygulamaları mevcuttur. 2023 yılına kadar enerji yöneticisi görevlendirmekle yükümlü olan binalarda referans değere göre en az %15 enerji tasarrufu sağlanması zorunluluğu bulunmaktadır. Uygulama rehberinde belirtilen enerji verimliliği uygulamalarına ek olarak, bu çalışmada, hastanelerde diğer binalardan farklı olan bazı enerji verimliliği uygulamaları belirtilmiştir. Özellikle bina otomasyonu ile basınç ilişkileri korunarak kullanım dışı zamanlarda ameliyathanelerdeki debi azaltımı (gece modu), yoğun bakımlarda H13 yerine F9 filtre kullanımı ve basınçlı hava sisteminde basıncın mümkün olan en düşük değere göre ayarlanması ve atık ısıdan ısı pompaları ile faydalanılması ele alınmıştır. Ameliyat olmadığında klima santrallerini gece modunda çalışma ile vantilatör ve aspiratörden %25 debi azaltımı için yaklaşık %33.7 enerji tasarrufu imkanı olduğu hesaplanmıştır. Yoğun bakımlarda H13 yerine F9 filtre kullanımı ile Türkiye genelinde işletme maliyetinden 40,640,000 TL tasarruf edilebileceği bulunmuştur.
Examination Of The Relationship Between Sustainable Nutritional Behaviors With Nutritional Knowledge Level And Body Mass Index
Authors: ÖZÜPEK Gökçen , ARSLAN Müge
Published: October 2021

Aim: The aim of this study is to examine the relationship between sustainable nutrition behaviors, nutritional knowledge levels and body mass index (BMI) of the students of the Department of Nutrition and Dietetics. Materials and Methods: A survey consisting of sociodemographic characteristics, nutritional status, questions about sustainable nutrition, frequency of food consumption and general nutrition knowledge questionnaire scale was applied to a total of 190 students studying at the Department of Nutrition and Dietetics at Istanbul Aydın University. Results: This study consisted of 190 students, 8.9% male and 91.1% female, with a mean age of 21.32±2.832 years. The rate of being overweight for male students is higher than female students (p<0.05). Majority of the students skip meals (p>0.05) and the most skipped main and snack meals is lunch (p>0.05) and mid-morning meal (p<0.05). The majority of students have heard the concept of sustainable nutrition (p<0.05), and have heard it mostly by a dietitian/nutritionist (p>0.05). Most of the students think that sustainable nutrition has a positive effect on health and economy (p>0.05). Students believe that sustainable nutrition is more suitable for healthy adults (p>0.05) and is applied due to environmental health protection (biodiversity and natural habitats) (p>0.05). Students think that the content of sustainable nutrition is mostly vegetables and fruits (p>0.05) and sustainable nutrition can contribute to agricultural economy, farmer income (p<0.05) and consumer consciousness (p>0.05). In sustainable food supply and consumption, students pay attention the most that packaged products is not damaged/opened/deformed (p>0.05). Students support the most seasonal food sales among sustainable food production incentive plans (p>0.05). The general nutritional knowledge levels of students with underweight is found to be higher (p>0.05). Conclusion: Students' level of hearing the concept of sustainable nutrition and their general nutritional knowledge status is high. Students with low BMI have higher nutritional knowledge levels.
The Relationship Between Blood Pressure Variability And Renal Progression In Hypertensive Patients With Chronic Kidney Disease
Authors: Duru Huseyin , KARA Ekrem
Published: October 2021

Objective: To evaluate the effect of 24 hour systolic blood pressure (SBP) and diastolic blood pressure (DBP) variability (BPV) on renal progression in hypertensive patients with chronic kidney disease (CKD) Methods: A total 59 hypertensive patients (mean age: 54.2±14.6 years, 50.8% male) with CKD who underwent 24 hours ambulatory blood pressure measurement (ABPM) were included. Data on SBP, DBP, BPV coefficients (VC) for SBP (SBP-CV) and DBP (DBP-CV) were recorded. A decrease in e-GFR of <5 ml/min/year was considered as normal renal progression and a decrease in ≥5 ml/min/year was considered as rapid renal progression. Results: Overall, 40.6% of the patients had uncontrolled HT, while 45.8% had non-dipper pattern. Mean±SD daytime and night-time SBP and SBP-VC values were 135.3±17.9 mmHg, 128.6±23.0 mmHg, 11.7±2.8 and 9.5±3.6, respectively. Mean±SD daytime and nigh-time DBP and DBP-VC values were 84.5±13.4 mmHg, 77.2±16.1 mmHg, 13.8±3.8 and 12.0±3.7, respectively. Rapid renal progression was detected in 25.4% of patients with no significant difference in daytime, night-time and total SBP, SBP-VC, DBP and DBP-VC values between patients with rapid vs. natural renal progression. The regression analysis adjusted for age, gender, presence of DM, baseline e-GFR and dipping status revealed no significant impact of SBP-VC and DBP-VC in predicting rapid progression (p> 0.05). Conclusion: In conclusion, our finding revealed no significant association between BPV and renal progression in hypertensive patients with CKD. Larger scale prospective, randomized controlled trials with longer follow-up are needed to clarify this issue.
Sedimentological and Heavy Metals Characteristics of Streets Dust in some Areas East of Baghdad for 2020
Authors: Jassim Huda Hadi
Published: October 2021

Road-side dust samples were collected during August in 2020 from selected areas of, Al-Rusafa, Baghdad, Iraq. A sedimentological and mineralogical analysis of street dust was conducted. Three areas were selected to study street dusts which are Al-Baladitat, Al-Obaidi and Ziona. The laboratory analyses were done in the Department of Geology, College of Science, University of Baghdad. The heavy metal contents were determined in the roadside dust using XRF Method. It was found that the dust is of muddy texture, and is believed to be transmitted with the various storms blowing on Baghdad or by the wheels of Cars. The results of mineralogical investigation revealed that the dust samples composed of quartz, feldspar, calcite, gypsum and sedimentary rocks fragments, as light minerals and the heavy minerals were found as garnet, epidote, chlorites, pyroxene, biotite, zircon, muscovite, hornblende, tourmaline. The heavy metals (Fe, Co, Ni, Cu, Zn and Pb) in these streets dust samples were studied and used as indicator for pollution. two o main indices are applied: contamination factor, and pollution load index. The contamination factor for Co, Zn, Pb, and Ni is classified as class 2, which indicate moderately contamination, while the contamination factor for Fe and Cu is classified as class 1, which indicate low contamination. The pollution load index values in the all of studied sites are classified as class 2 (Deterioration on site quality) indicating local pollution, as well as denote perfection with class 0 of no pollution.
MATERIAIS PEDAGÓGICOS PARA O ENSINO DE GEOGRAFIA FÍSICA NO ENSINO FUNDAMENTAL II
Authors: De Almeida Rangel Luana
Published: October 2021

Esta pesquisa parte de inquietações referentes ao papel da Geografia Física no currículo de Geografia na educação básica e da abordagem dos conteúdos relacionados à temática. Portanto, a pesquisa teve como objetivo propor a criação e utilização de recursos didático-pedagógicos para o ensino de Geografia Física. (GF) Para tal, analisou-se o livro didático (LD) “Expedições Geográficas” do 6° ano do Ensino Fundamental visando identificar lacunas na abordagem de conteúdos. Optou-se pela análise do livro do 6° ano, pois, apresenta, de acordo com a BNCC e o Currículo Carioca, mais conteúdos voltados para a temática de GF. Os materiais e atividades lúdico-pedagógicas elaborados foram baseados nas lacunas encontradas no LD com relação à GF. Com a análise do LD, observou-se que há ausência de temáticas específicas relacionadas à sustentabilidade, riscos e solos. A elaboração de materiais para o ensino desses temas é uma ferramenta que pode contribuir para a aprendizagem significativa e despertar o interesse dos estudantes. Conclui-se que há necessidade da produção de materiais para abordar temas ausentes no LD. Além disso, verificou-se que atividades lúdicas são importantes para o ensino de Geografia Física, pois permitem maior envolvimento dos alunos com os conteúdos.

Palavras-chave

Recursos pedagógicos, Materiais lúdicos, Educação Geográfica, Currículo Carioca.

 

PEDAGOGICAL MATERIALS FOR PHYSICAL GEOGRAPHY TEACHING IN MIDDLE SCHOOL

Abstract

This research starts from concerns regarding the role of Physical Geography in the Geography curriculum in basic education and the approach to the contents related to the theme. Therefore, these research aimed to propose the creation and use of didactic-pedagogical resources for teaching Physical Geography.For this, the textbook “Geographical Expeditions” of the 6th year of middle school was analyzed in order to identify gaps in the content. We opted for the analysis of the 6th grade book, because it has, according to the BNCC and the Carioca Curriculum, more content focused on the subject of Physical Geography. According to the Brazilian Common Core Curriculum and the Carioca Curriculum, the 6th grade has more content about physical geography. The pedagogical materials and activities developed were based on the gaps found in the textbook. It was also observed that such content has gaps, such as the lack of integration between themes related to sustainability, socio-environmental risks and soils. It is concluded that the development of playful materials for teaching Physical Geography is a tool that can contribute to meaningful learning. In addition, it was found that recreational activities are important for Physical Geography learning.

Keywords

Pedagogical resources, Playful materials, Geographic Education, Carioca Curriculum.
NAČELO TRIPARTIZMA I NjEGOV NASTANAK
Authors: Vidojević Boban
Published: October 2021

The primary goal of this paper is to point out the current development, current situation, current tendencies and perspectives of the development of tripartism at the national and international level. Emphasis is placed on clarifying the concept, subject, subjects and basic features of tripartism, as well as the analysis of formal and informal forms of tripartite cooperation, with special reference to economic and social councils and other institutional forms of tripartism. Tripartite consultations and negotiations regulate the relations and harmonize the interests between: a) the state, b) the owner of the capital and c) the owner of the labor force. Apart from them, the processes of tripartite cooperation in recent decades have increasingly involved some other entities, for example: consumer representatives, representatives of environmental movements, farmers, retirees and others. Their role in the functioning of tripartite relations is becoming increasingly important, so it can be reasonably expected that the contents of tripartite cooperation in the future will increasingly meet the activities of these entities.
Results on (Engel, Solvable, Nilpotent) Fuzzy Subpolygroups
Authors:   Faculty of Science, Payame Noor University, MOHAMMADZADEH ELAHE , ALI BORZOOEI RAJAB ,   Shahid Beheshti University, Tehran, Iran
Published: October 2021

In this paper, ﬁrst we deﬁne the notion of an Engel polygroup, to get further properties on Engel fuzzy subpolygroups. Moreover, we prove that every normal fuzzy subpolygroup of an Engel polygroup is Engel. Furthermore, we introduce the notions of solvable and nilpotent fuzzy subpolygroups and we get some of their properties. Finally we investigate the relations among solvable and nilpotent fuzzy subpolygroups with Engel fuzzy subpolygroups.
Vertex-Edge Roman Domination
Authors:   School of Arts, Science and Humanities, SASTRA Deemed University, Thanjavur, India, KUMAR H. NARESH , VENKATAKRISHNAN Y. B.
Published: October 2021

A vertex-edge Roman dominating function (or just ve-RDF) of a graph G = (V,E) is a function f : V (G) →{0, 1, 2} such that for each edge e = uv either max{f(u),f(v)}≠0 or there exists a vertex w such that either wu ∈ E or wv ∈ E and f(w) = 2. The weight of a ve-RDF is the sum of its function values over all vertices. The vertex-edge Roman domination number of a graph G, denoted by γveR(G), is the minimum weight of a ve-RDF G. In this paper, we initiate a study of vertex-edge Roman dominaton. We ﬁrst show that determining the number γveR(G) is NP-complete even for bipartite graphs. Then we show that if T is a tree diﬀerent from a star with order n, l leaves and s support vertices, then γveR(T) ≥ (n − l − s + 3)∕2, and we characterize the trees attaining this lower bound. Finally, we provide a characterization of all trees with γveR(T) = 2γ′(T), where γ′(T) is the edge domination number of T.
Differential Subordination and Superordination for a Generalized Differential Operator Involving Mittag-Leffler Function
Authors:   Faculty of Science and Technology, Universiti Kebangsaan Malaysia,, ELHADDAD SUHILA , DARUS MASLINA
Published: October 2021

Abstract. Owning to the importance and great interest of linear operators, a generalisation of linear derivative operator He m δ,p(α, β, a1, b1)f(z) is newly introduced in this study. The main objective of this paper is to investigate various subordination and superordination related to the aforementioned generalised linear derivative operator. Additionally, the resultant sandwich-type of this operator is also considered.
RETRACTED Warped Product Pointwise Semi-slant Submanifolds of Sasakian Manifol Retracted
Authors:   Faculty of Mathematics, University of Bucharest, Romania, MIHAI ION , UDDIN SIRAJ , MIHAI АДЕЛА
Published: October 2021

Recently, B.-Y. Chen and O. J. Garay studied pointwise slant submanifolds of almost Hermitian manifolds. By using the notion of pointwise slant submanifolds, we investigate the geometry of pointwise semi-slant submanifolds and their warped products in Sasakian manifolds. We give non-trivial examples of such submanifolds and obtain several fundamental results, including a characterization for warped product pointwise semi-slant submanifolds of Sasakian manifolds.
Application of the Hopf Maximum Principle to the Theory of Geodesic Mappings
Authors:   Finance University under the Government of the Russian Federation,, STEPANOV SERGEY , MIKEŠ JOSEF ,   Palacky University, Czech Republic
Published: October 2021

In the present paper we consider some applications the Hopf maximum principle and its generalization to the classical theory of geodesic mappings. As a result, a series of classical theorems on geodesic mappings become consequences of our statements which we shall prove in the present paper.
Consideraciones éticas sobre COVID-19 y pacientes frágiles con demencia.
Authors: Bombón-Albán Paulina E. , Duque-Peñailillo Lissette , Núñez-Herrera Alberto T.
Published: October 2021

Estimada Editora: La crisis de la enfermedad por coronavirus 2019 (COVID-19), desafió a cuidar a nuestros pacientes adultos mayores (AM), en la comunidad, así como en centros de larga estadía y en el hospital. Esta población, y especialmente los AM frágiles con demencia y los pacientes que experimentan una comorbilidad significativa son los más vulnerables a las graves consecuencias de la COVID-19.
Función cognitiva en adultos mayores con y sin dedos de Dawson relacionados con enfermedad de pequeño vaso cerebral.
Authors: Del Brutto Oscar H. , Mera Robertino M. , Silva Patricia , Costa Aldo F.
Published: October 2021

Antecedentes/objetivo: Los dedos de Dawson, tradicionalmente asociados con esclerosis múltiple, han sido – además – recientemente vinculados con hiperintensidades de sustancia blanca causadas por enfermedad de pequeño vaso cerebral. En este contexto, dichas lesiones corresponderían a daño venular, podrían representar estadíos avanzados de enfermedad de pequeño vaso y estarían teóricamente asociados con deterioro cognitivo. En el presente estudio se intentó determinar si los dedos de Dawson se asociaron con un peor desempeño cognitivo en adultos mayores. Métodos: Estudio poblacional realizado en personas de 60 años o más, residentes de tres poblados del litoral Ecuatoriano (Atahualpa, El Tambo y Prosperidad). De un total de 712 adultos mayores identificados mediante censos puerta-a-puerta, 590 fueron sometidos a IRM cerebral y de éstos, a 575 también se les realizó valoración cognitiva mediante la prueba de Montreal (MoCA). Se seleccionaron los 157 individuos con hiperintensidades de sustancia blanca de moderada a severa y se determinó la presencia de dedos de Dawson en dichos sujetos. La asociación independiente entre dedos de Dawson y desempeño cognitivo (como variable dependiente) fue evaluada mediante un modelo de regresión linear ajustado por factores demográficos y de riesgo cardiovascular, así como por los demás biomarcadores de enfermedad de pequeño vaso cerebral. Resultados: De los 157 individuos con hiperintensidades de sustancia blanca de moderada a severa, 17 (11%) presentaron dedos de Dawson en IRM. La puntuación promedio en el MoCA fue de 14.5±6.4 en sujetos con dedos de Dawson y de 17.3±6.2 en aquellos sin este biomarcador de neuroimagen. La asociación entre dedos de Dawson y puntaje en el MoCA fue marginal en el modelo univariado (p=0.082), mientras que dicha asociación se diluyó completamente luego de ajustar por las covariables de interés (β: -0.31; 95% I.C.: -3.23 – 2.60; p=0.833). El 83.5% del efecto de los dedos de Dawson en el desempeño cognitivo estuvo mediado por la edad. Conclusión: Los dedos de Dawson no se asocian independientemente con el desempeño cognitivo en individuos con enfermedad de pequeño vaso. La mayor parte de esta asociación se encuentra mediada por la edad.
Marcadores cognitivos, biológicos, anatómicos y conductuales del deterioro cognitivo leve y la enfermedad de Alzheimer. Una revisión sistemática.
Authors: Bonilla-Santos Jasmín , Zea-Romero Erika Y. , González-Hernández Alfredis , Cala-Martínez Dorian Y.
Published: October 2021

La enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa progresiva que afecta el 50% de las personas mayores de 85 años y es una de las más comunes en la edad adulta y la causa más frecuente de demencia en los países desarrollados. El objetivo fue determinar cuáles han sido los marcadores cognitivos, biológicos, anatómicos y conductuales del deterioro cognitivo leve (DCL) y la EA más estudiados en los últimos 10 años. Se buscaron estudios en las bases de datos Scopus, Pubmed y Sciencedirect. Se identificaron 187 artículos, de los que finalmente se seleccionaron 23 con texto completo. Los estudios correspondieron a marcadores cognitivos (15 estudios), biológicos (8 estudios), anatómicos (3 estudios) y conductuales (2 estudios). Los marcadores identificados permitirán orientar el diseño de programas de detección temprana y futuras intervenciones que disminuyan los efectos neuropatológicos y las alteraciones significativas en la calidad de vida.
Instrumentos que evalúan la inteligencia emocional en estudiantes universitarios: Una revisión sistemática.
Authors: Jamba-Pedro da Fonseca Amandio , Vidal-Espinoza Rubén , Cossio-Bolaños Marco A. , Hernández-González Osvaldo , Gómez-Leyva Inalvis , Gomez-Campos Rossana
Published: October 2021

Objetivo: Identificar los estudios que han aplicado instrumentos de Inteligencia Emocional en jóvenes universitarios en los últimos 20 años (2001 a 2020). Metodología: Se efectuó un estudio documental (revisión sistemática). La selección de estudios primarios se efectuó en las Bases de Datos Scopus y Scielo. El rango de años sistematizados fue desde 2001 a 2020. Los estudios están publicados en idioma inglés, español, portugués y francés. Se utilizó las palabras clave en inglés: Instruments, emotion inteligence, evaluation; en español: instrumentos, inteligencia emocional, evaluación. Para registrar la información se utilizó la técnica de la observación, y el instrumento fue una ficha de observación. Resultados: El 75% (n=12) de los estudios primarios fueron publicado en idioma inglés, 18,8% (n=3) en español y 6% (n=1) en francés. También, se destaca que el 81.3% (n=13) de los artículos fueron publicados en la base de datos Scopus, 18,8% (n=3) en la base de datos Scielo. El mayor número de publicaciones fueron en los últimos 5 años (62,5%, n=10). Los instru- mentos que fueron utilizados para evaluar la IE, fueron MSCEIT, Bar-On y TMMS. Conclusión: Se verificó que los instrumentos de Inteligencia Emocional (IE) que más se aplicaron en jóvenes universitarios fueron el MSCEIT, el Bar-On y TMMS, además, los estudios desde el año 2001 hasta el 2020 fueron incrementándose paulatinamente. Los resultados sugieren el uso y aplicación de estos instrumentos para muestras de jóvenes universitarios.
Heterotopía en banda en paciente con crisis de ausencia: A propósito de un caso.
Authors: Ramón y Cajal-Calvo Juan , Bello-Franco Carlota , Gimeno-Peribañez María José , Sáez-Valero Eduardo
Published: October 2021

La heterotopía en banda, también conocida por el nombre del síndrome de la doble corteza consiste en una anomalía de la migración neuronal, que produce crisis convulsivas y retraso psicomotor.