bluuebunny/crossref_metadata_2025 huggingface dataset:
Physical Activity and Sleep Quality of Elderly During The COVID-19 Pandemic Period
Authors: Prastica Vinanda Maria , Susumaningrum Latifa Aini , Rasni Hanny , Susanto Tantut , Kurdi Fahruddin , Qudsyiyah Roro Dewi , Nasikhin Khoirun
Published: September 2021

COVID-19 pandemic has caused the changes on the physical activity of elderly. Physical activity can affect the sleep quality of elderly. This research aims to analyze the correlation between physical activity and quality of sleep during the COVID-19 pandemic at UPT PSTW Bondowoso. This research uses a cross sectional study design. There are 44 samples of elderlies using consecutive sampling. The instrument of this research is the characteristics of the elderly questionnaire. The elderly's physical activity instrument uses the Physical Activity Scale for Elderly (PASE) and the elderly's sleep quality uses Pitssburgh Sleep Quality Index (PSQI). The analysis of research data uses Spearman-rho (p-value <0.05). The results show that on physical activity, the median result (69.98) and good sleep quality (65.9%). The result of the correlation test shows that there is a correlation between physical activity and sleep quality (r = -0,364; p = 0,015). The conclusion of this research, is that the important of physical activity in maintaining the quality of sleep. Therefore, elderly should maintain physical activity to obtain a good sleep quality.
“The beginning of knowledge is the discovery of something we do not understand” -Frank Herbert
Authors: None None
Published: September 2021

None
Failure and Management of Direct Restorations
Authors: Pujar Dr. Madhu , Gopeshetti Dr. Pallavi , Uppin Dr. Veerendra , B Hanjagi Dr. Seema , Athulchandra Dr.
Published: September 2021

The clinical assessment of a failing restoration plays an imperative role in recognising the cause of failure and helps in decision making for replacement or repair of the restoration. This paper describes about how to appropriately diagnose a failing restoration and either replace or repair the restoration as soon as possible without causing more damage to the natural tooth.
Amalgam phase-out, an environmental safety concern: a crosssectional study among general dental practitioners in Pakistan
Authors: Khan Salman , Khalid Naima , Bajwa Obaid , Qamar Taha , Kazmi Ali , Tariq Amina
Published: September 2021

Background: Amalgam has been the gold standard for restorations in posterior teeth. Mercury, a major component of dental amalgam, is considered an environmental pollutant. The Minamata Convention on mercury recomends a reduction in the use of mercury-containing products. Since Pakistan is a signatory to the Convention, the same amalgam phase-out limitations are implemented in Pakistan. Aims: To identify and assess the use of amalgam and its waste management by dentists in Pakistan post-Minamata Convention guidelines. Methods: A cross-sectional study was conducted in Lahore among 520 general dental practitioners in 2019. Results: The sample size for the study was calculated as 500; the questionnaire was distributed among 550 dentists. Dental amalgam was used by only 41.6% of the dentists in their practice; 55.0% perceived it to be a health risk. Most of the dentists (76.3%) were unaware of the proper disposal protocols for dental amalgam and 76.5% were unaware of any guidelines regarding amalgam use and disposal. Conclusion: Although there is a gap in knowledge among the dentists regarding amalgam disposal, dentists in Pakistan are reducing their use of dental amalgam in accordance with the guidelines of the Minamata Convention.
PHARMACOLOGICAL ACTIVITY OF AN AMINOCHROMENE DERIVATIVE IN THE TREATMENT OF BREAST CANCER (EXPERIMENTAL STUDY)
Authors: O.N. Deryabina , Е.В. Blinova , E.A. Samyshina , T.A. Demura , A.A. Epishkina , M.O. Dudina , O.M. Tumutolova
Published: September 2021

We studied an antitumor effect of a compound of 4-aminochromene derivatives (AX-554) in the tumor system of breast cancer Ca-755. We used C57Bl / 6 mice, which were subcutaneously injected with a suspension of Ca-755 tumor cells into the right axillary region in the amount of 1×106 cells in 199 solution. AX-554 was administered intragastrically through a tube once on the 48 hours after tumor transplantation, in comparison with reference antitumor drugs with proven antitumor activity, which were used as doxorubicin, paclitaxel. The antitumor activity was judged by the survival rate of animals, the size and morphology of the tumor node. It was shown that the 4-aminochromene derivative AX-554 increases the survival rate of animals with breast cancer by 30% compared with the control group and by 10% with the group receiving doxorubicin. with control. In the study of tumor sections stained with hemotoxylin and eosin in animals treated with AX-554, there were single tumor cells in a state of severe dystrophy, the necrosis zone was 90%, which indicates drug pathomorphosis of the 3rd degree. In animals treated with doxorubicin, atypical cells in the center of the tumor node retained their structure, in the periphery - cells in a state of dystrophy, foci of necrosis accounted for 60%. The morphological picture of the tumor in animals treated with paclitaxel was a drug pathomorphosis of the 2nd degree.
BIOMONITORING OF OIL-CONTAMINATED SOILS
Authors: M.D. Demelkhanov , Z.P. Okazova
Published: September 2021

One of the main problems of environmental protection at the present stage is the contamination of soil by oil and products of its processing. Oil and petroleum products are dangerous and the most common environmental pollutants. Oil pipelines refer to linearly extended objects, for which an emergency situation is quite typical and widespread. The impact of such objects on the natural environment is usually integral. The problem of remediation of soils contaminated with oil and its processing products is one of the first places. The study of the properties of the soil contaminated with oil and oil products acquires practical and scientific significance at the level of the Chechen Republic. The purpose of the research is to study the possibility of using test plants as indicators of soil pollution by oil and its products, a comparative assessment of various test plants in specific soil and climatic conditions. Materials and methods: theoretical - analysis of literature on the problem of oil pollution, laboratory. The main place in the work is occupied by modeling experience. The study was carried out on the territory of the city of Grozny, with a predominance of leached chernozems. In an urban environment, in the process of burning fuels, sulfur and nitrogen oxides are formed in large quantities, which in the course of chemical reactions form sulfurous, nitric and nitrous acids. The toxicity of urban soils, which is explained by the content of xenobiotics in them, in the experiments evaluating the total phytotoxicity was expressed by inhibition of the growth of the aboveground part of the test plants. It has been determined that it is most expedient to use winter rye and parsley as test plants.
MORPHOLOGICAL CHANGES IN PLANTS AS A PARAMETER BIOINDICATION ASSESSMENT
Authors: R.R. Dandaev , Z.P. Okazova
Published: September 2021

Morphological changes in plants are widely used as an indicator. This is an important indicator parameter. The reason for its widespread use is its low cost, availability and simplicity of research, no need for highly qualified personnel and the presence of a special laboratory. Numerous studies are devoted to the standardization of the test material and the conditions for its use. The national monitoring system of all developed countries includes a large arsenal of morphological indicators, which made it possible to create maps of anthropogenic impacts. The aim of the research is to study the possibility of using morphological changes in plants as a parameter of bioindication assessment. Material and methods: theoretical - analysis of literature on the problem of environmental monitoring, laboratory. Assessment of the degree of plant change is associated with internal factors and different sensitivity of plant organisms. For the purpose of active monitoring, a large group of plants is recommended. For passive monitoring and determination of the consequences of environmental pollution, indicator signs of plants growing freely in the study area are used. Bioindication methods are useful for assessing the state of the environment. The study of the reaction of plants to the level of pollution makes it possible to assess its consequences. The study of urban communities makes it possible to develop ways to stabilize them, for example, by changing loads. Bioindication is an important addition to instrumental methods.
STUDY OF RESISTANCE TO ANTITUBERCULOSIS DRUGS IN PATIENTS WHO ARE IN STATIONARY TREATMENT IN THE DEPARTMENT OF RESISTANT FORMS OF PULMONARY TUBERCULOSIS
Authors: A.V. Tkachev , V.A. Baturin
Published: September 2021

A comparative study of resistance to anti-tuberculosis drugs in patients with newly diagnosed pulmonary tuberculosis and in patients with chronic forms of tuberculosis who were treated in an anti-tuberculosis hospital was carried out. We examined 142 patients treated in the department of resistant forms of tuberculosis. A complete bacteriological study of sputum for Mycobacterium tuberculosis was carried out with the determination of sensitivity to anti-tuberculosis drugs during the cultivation of microorganisms on a liquid nutrient medium in a system with automated registration of bacterial growth and on a dense nutrient medium of Lowenstein-Jensen using the method of absolute concentrations. Methods of PCR analysis were also used. According to the anamnesis, two groups of patients were formed: 82 patients with newly diagnosed tuberculosis and 60 patients with a chronic course of the disease or with a relapse of the disease. According to the age structure, patients under the age of 50 prevailed in both groups. At the same time, in the first group there was a significant number of patients aged 18-29 years - 20.7%. In the second group, the number of patients aged 18-29 years was significantly less - 5%. Despite the fact that all patients were assigned to the category of multidrug-resistant pathogen and were treated in the unit of resistant forms of tuberculosis, it was important to assess the level of Mycobacterium tuberculosis resistance separately for patients in each of the selected groups. The largest differences between groups were found in the assessment of second-line drug resistance. Patients of the second group showed high resistance to fluoroquinolones - 30% and amikacin - 41.6%. In patients with newly diagnosed pulmonary tuberculosis (first group), resistance to fluoroquinolones was 9.7%, and to amikacin - 17.1%. Capreomycin was the most effective in both groups. The resistance of the causative agent of tuberculosis in patients of the first group was 4.9%, in the second - 11.6%.
PERIPHERAL VASCULAR TONE IN YOUNG RESIDENTS OF THE EUROPEAN NORTH WITH ENDOTHELIN -1 GENE POLYMORPHISM LYS198ASN
Authors: S.N. Levitsky , E.L. Kurochkina , A.V. Sumarokova , I.A. Shabalina
Published: September 2021

The frequency of the endothelin-1 (EDN1) - Lys198Asn (rs5370) gene polymorphism in the population of the young population of the city of Arkhangelsk and its possible relationship with the indicators of peripheral vasoconstriction were studied. The population of young healthy ethnic Russians aged 18-22 years, from the moment of birth, living in the territory of the Arkhangelsk region was examined. Genotyping was performed by polymerase chain reaction, and the level of EDN1 was determined by enzyme immunoassay. In the course of the study, it was found that individuals with the GG genotype make up 63%, heterozygotes GT-31%, homozygotes for the mutant allele T-6%. The concentration of endothelin-1, one of the main factors affecting the normal functioning of the endothelium and whose role in the development of cardiovascular pathology has been proven by numerous studies, was 0.45 fmol / ml in the group with the GG genotype, and in the group of carriers of the mutant allele (GT+TT), was significantly higher by 27.4% (p=0.04). When analyzing the main indicators of peripheral hemodynamics in individuals with different genotypes, no statistically significant differences were found, but an increase in all indicators was observed when carrying the T allele. It can be assumed that individuals with the GT and TT genotypes are at risk of developing cardiovascular pathology. In addition, 23.6% of the young population had a hypertonic reaction to the load. In the present work, no significant differences in central and peripheral hemodynamic parameters were found in individuals with different genotypes for the EDN - 1 gene Lys198Asn polymorphism, which may be due to the small number of examined patients, so it is necessary to conduct further large-scale population studies.
THE EFFECT OF CYTOSTATIC DRUGS ON THROMBOCYTOPOIESIS IN RATS WITH WALKER-256 CARCINOMA
Authors: L.A. Balykova , A.V. Siprov , V.I. Inchina , T.V. Tarasova , L.M. Mosina , E.A. Korovyakova , M.A. Solovieva , E.N. Gvozdikova , D .A. Khaidar , I.V. Saushev
Published: September 2021

Among malignant neoplasms of women, breast cancer (BC) takes the leading place and is the cause of high mortality and complications. Side effects in the form of anemia, thrombocytopenia, bleeding, etc. often develop during cytostatic therapy, which is the main method of treatment and prevention of further development of the oncological process. In this regard, the problem of reducing side metabolic disorders remains relevant and creates a search field for the use of drugs aimed at stabilizing functions, both at the cellular and organ levels.
The aim of the study was to evaluate the effect of cytostatic drugs on thrombocytopoiesis in rats with WALKER-256 carcinoma. The study included 60 rats, which, depending on the type of treatment, were divided into 5 groups. A week after the start of chemotherapy, the greatest increase in the number of platelets was in the presence of liposomal ethylmethylhydroxypyridine succinate. We recorded that the myeloprotective effect was 1/3 better in liposomal ethylmethylhydroxypyridine succinate compared to its non-liposomal form. Therefore, individuals those receiving cytostatic drugs in the treatment of breast cancer need protection from myelopoiesis. In the studies carried out by us, it was shown that oxidative stress occurred in animals against the background of treatment with cytostatics. It was its rapid development that caused damage to the platelet cell membranes. In this regard, we have proposed a drug with a pronounced antioxidant efficacy. The introduction of an antioxidant into the generally accepted standard treatment of a tumor process has made it possible to experimentally select methods for delivering the drug to the targets of damage using liposomal forms. The study obtained data proving the effectiveness of the use of liposomal ethylmethylhydroxypyridine succinate (50 mg / kg), in contrast to its free form, which prevents the development of thrombocytopenia induced by the administration of cytostatic drugs to rats with Walker-256 carcinoma.
LEGAL BASIS FOR INFORMING PATIENTS ABOUT THE RULES FOR THE USE OF MEDICINES
Authors: T.I. Okonenko , E.S. Egorova , A.K. Khrutsky , G.A. Antropova
Published: September 2021

Pharmaceutical specialists play the leading role providing informations and recommendations how to use drugs. In national regulatory instruments have requirements to implement pharmaceutical information and counseling. Besides pharmacists, patients can get advice of medical specialists who prescrib drug therapy. So, a patient is informed on the rational using medicine by 2 specialists. In such a situation, is important to division the areas of responsibility in the explaining the rules of use of drugs. The Purpose of the Study. Analysis of the legal framework in the field of consulting the patient during medicines sales. A readiness pharmaceutical specialist to provide informations prescribed medicines in accordance with the law has been assessed. Material and methods. An assessment of the regulatory framework for pharmaceutical information and counseling services was given. Questionnaire face-to-face survey of 154 pharmaceutical workers of the Novgorod region was carried out and the readiness was analyzed their readiness to provide information and counseling services in case of saling a prescribed drug according to the legislation. Results. Almost 30,0 % of pharmacy workers indicated that it is not always necessary to explain a doses of medicine, as this information is communicated to a patient by a doctor. 13.63% of respondents, releasing a drug prescribed by a doctor, always report information on the conditions of its storage place, the rest is given only in case if a buyer requires or if it is necessary to observe a special temperature for drug storage. At the same time, 22,73% of pharmaceutical chemists always inform patients about possible drug interactions. Conclusion. During the study, problems were identified in the implementation of the labor function to provide information services by pharmacy workers.
CHARACTERIZATION OF THE IMMUNE STATUS OF YOUNG HOCKEY PLAYERS PUBERTY
Authors: N.А. Simonova , N.P. Petrushkina , E.V. Zhukovskaya , O.I. Kolomiets
Published: September 2021

Relevance. In modern publications, sufficient attention is paid to the study of the cellular composition of peripheral blood and the immune status of athletes. These studies are carried out at various stages of the training process in order to establish a connection between the registered changes and the nature and severity of muscle loads. The available literature data mainly relate to the indicators of the immunity of adult athletes involved in various sports, recorded at various stages of training and characterizing the adaptation to muscular load. The state of the immune system largely determines the success of a sports career in modern sports. Aim of the study: to assess the immune profile (cellular and humoral link) of pubertal hockey players at the beginning of the preparatory stage of the training period. Materials and methods. To assess the immune profile (cellular and humoral link) of pubertal hockey players at the beginning of the preparatory stage of the training period, the relative and absolute content of lymphocytes was studied by the method of immunophenotyping with the determination of their subpopulation composition (CD3 +, CD3 + CD4 +, CD3 + CD8 +; CD3- CD16 + CD56 +, CD19 +, CD4 + / CD8 +), and by turbidimetry - specific proteins (immunoglobulins A, G, M). Results. The obtained values of the studied indicators did not differ from those of adolescents who do not go in for sports, and generally fit into the age norms. Isolated cases of deviations are associated with the characteristics of the morbidity of the examined adolescents. The recorded immune profile of athletes will be used as reference values during the continuation of the study (at the end of the pre-competition and post-competition periods), the purpose of which is to monitor the impact of the training process on the immunity of athletes of puberty. The obtained values of the studied indicators do not differ from those in the control and, fit into the age norms. In conclusion, the authors come to the conclusion that it is possible to use the recorded immune profile of athletes as reference values during the continuation of the study (at the end of the preparatory stage and at the end of the competitive period), the purpose of which will be to assess the impact of the training process on the immunity of athletes of puberty.
REHABILITATION OF ATHLETES AFTER SHOULDER INJURY: A COMPARATIVE ASSESSMENT OF EFFECTIVENESS AND SATISFACTION WITH RESULTS
Authors: D.N. Bobunov , S.S. Solomakhin , L.Yu. Suleimanova , A.V. Senyukov , A.S. Kolomazhina , T.S. Lashkhia , A.R. Yakubchak
Published: September 2021

The main task in the rehabilitation of athletes with traumatic injuries of the humerus and surrounding soft tissues is effective and painless recovery at all stages of treatment. For the highest quality recovery of athletes, it is necessary to consider the structural and functional changes in the shoulder joint in order to draw up an individual treatment plan. The aim of the study was to assess the effectiveness of rehabilitation measures in athletes of different age groups with traumatic injuries of the humerus and soft tissues, considering their mental state. With the help of methods for assessing personal response to illness - "Syndrome of psychosensory-anatomical-functional maladjustment" (SPSAFD), the effectiveness of rehabilitation measures was assessed in 273 athletes with a diagnosis of shoulder girdle and shoulder injuries (S40-S49) S46.0 Injury of the rotator cuff tendon; T92.5 Consequences of injuries to the tendons and muscles of the upper limb) and prevention of damage to the rotator cuff of the shoulder joint (ICD-10), it was found that before the rehabilitation treatment, athletes had a state of maladjustment against the background of the disease. Also, there was a positive dynamic in the personal response to the disease after a complex of rehabilitation measures for 3 months, recommended by the attending physician of physical therapy and sports medicine.
STUDY OF DIURETIC AND ANTI-INFLAMMATORY ACTIVITY OF INFUSION AND EXTRACT OF DRIED STRAWBERRY LEAVES
Authors: O.V. Yaborova , S.A. Sosnina , A.Yu. Turyshev
Published: September 2021

The search for new sources of medicinal plant raw materials for the production of drugs is one of the urgent tasks of modern pharmacy. The expansion of the range of medicinal plant raw materials is possible, first of all, due to the types systematically close to the official ones. In medical practice, wild strawberry leaves are used. Wild strawberry leaves are used in medicine as a diuretic, anti-inflammatory, antispasmodic, choleretic, hypoglycemic, antipyretic, hypolipidemic, antimicrobial and appetite-enhancing agent. Earlier studies of strawberry leaves have shown that they have a rich chemical composition and are widely cultivated in Russia, being an affordable source for mass procurement of raw materials, and are not used in scientific medicine. At the same time, in folk medicine, strawberry garden leaves are used similarly, and sometimes instead of wild strawberries. The proximity of the composition of biologically active substances of wild strawberries and garden strawberries.
To expand the modern nomenclature of medicines, studies on the comparative study of the toxicity and pharmacological activity of infusions and extraction forms from medicinal plant raw materials of strawberry leaves are relevant. In this regard, the study of the toxicity, diuretic and anti-inflammatory activity of the infusion of garden strawberry leaves and the extract of dry strawberry leaves is of practical interest for the formation of a scientific justification for their use in medical practice.
THE ROLE OF ESTROGENS IN THE AUTONOMIC REGULATION OF THE CARDIOVASCULAR SYSTEM IN MENOPAUSE
Authors: I.V. Neufeld , M.V. Kuznetsova , A.I. Zhirnyakov , I.V. Bobyleva , I.E. Rogozhina
Published: September 2021

Hot flashes are known to be associated with a variety of cardiovascular risk factors. There is evidence of a close relationship between hot flashes and autonomic dysfunction, while the parameter - heart rate variability (HRV) - is a surrogate marker for assessing the activity of the autonomic nervous system (ANS). However, changes in HRV can be caused by both aging and hormonal changes.
The purpose of this work is to consider the role of endogenous estrogens in the autonomic regulation of the cardiovascular system on the model of "acute estrogen deficiency" in cases of total oophorectomy and "partial estrogen deficiency" - in cases of hysterectomy with / without appendages.
44 women were included, mean age - 46.9 ± 2.2 years, whose HRV was assessed before surgery (1 week before surgery) and after (not less than 4 and not more than 5 weeks after surgery).
According to the results obtained, there were no statistically significant changes in both temporal and spectral HRV parameters in patients after hysterectomy (p> 0.05). On the contrary, patients with total oophorectomy in the postoperative period showed decreased HRV parameters characterizing the parasympathetic activity of the ANS, namely SDRR, rMSSD, pNN50, HF and the LF index, reflecting both sympathetic and parasympathetic effects on heart rate. Patients with total oophorectomy have a higher ratio of the sympatovagal LF / HF index; the work shows that this fact is most likely due to the predominance of sympathetic nervous influences induced by "acute" withdrawal of ovarian hormones due to the performed volume of surgery, and not as a result of surgery. as such, or its psychological consequences.
Thus, according to the above-described results of the study, patients in cases of total oophorectomy showed a decrease in the parameters of vagal HRV in the direction of sympathetic dominance, which may cause an increase in cardiovascular risk.
FEATURES OF THE DRUG ENFORCEMENT OF THE RURAL POPULATION OF THE REPUBLIC OF ADYGEA
Authors: B.G. Bochkarev , A.B. Goryachev , G.N. Samko , T.I. Kabakova , E.B. Bochkareva
Published: September 2021

Improving the availability of medical and medicinal care is the most important task of all levels of government and especially relevant in the context of modernization of the health system. The purpose of the work was to analyze the peculiarities of the functioning of the Drug Provision System of the Rural Population of the Republic of Adygea to identify reserves for its development and substantiate directions for further improvement, taking into account regional conditions. It was established that in the Republic of Adygea out of 160 units of medical organizations, the right of retail trade in drugs, 112 medical and obstetric items that have licenses for pharmaceutical activities are used by drug trading. A feature of the implementation of pharmaceutical activities in rural areas is the absence in most places of modern transport highways, which creates logistics problems and significantly complicates the regular delivery of drugs to the population. Among the positive points, the appearance of an additional way of delivering drugs to the feldsher-obstetric items located in hard-to-reach (mountainous) areas implemented in the federal population to ensure the necessary drugs is noted. The inclusion of pharmacies of partners in the system of ensuring the population did not require additional agreements and expenditures on their services, since this function does not carry additional costs, but at the same time increases their image. It has been established that over the past 2 years, the quality of drugs in the countryside residents decreased significantly. In the region, the number of current pharmaceutical activities has decreased by 21%, the number of operating paramedic-obstetric items has also decreased by 18%, and the number of pharmacies of the program has decreased by 2.8 times. Currently, unresolved problems of the organizational nature came to the fore, among which: the absence of working capital organizations for the acquisition of drugs, in the presence of extrabudgetary funds received from the implementation of paid medical services; insufficient legal training of individual officials of medical organizations in state procurement issues; the absence from the overwhelming number of retail trade licenses for transportation of goods of pharmacy assortment and others. The identified problems are based on the basis of the work plan of health authorities, pharmaceutical activities, medical and pharmaceutical organizations of the Republic of Adygea to improve the forms and working methods for the provision of agricultural drugs.
A CLINICAL EXAMPLE OF THE USE OF A HYDROKINETIC LASER WATERLASE IPLUS WITH A WAVELENGTH OF 2780 NM IN THE TREATMENT OF PURULENT PULPITIS
Authors: A.V. Polevaya , E.G. Borisova , L.P. Polevaya
Published: September 2021

The article presents a clinical example demonstrating the tactics of using the hydrokinetic Er, Cr:YSGG laser Waterlase Iplus with a wavelength of 2780 nm in the treatment of purulent pulpitis. The authors were faced with the task of showing the elimination of microorganisms in the treatment of purulent pulpitis, as well as the long-term results of endodontic treatment, using a specific clinical example. Objective is to describe the clinical features and effectiveness of the use of the hydrokinetic Er, Cr:YSGG Waterlase Iplus laser with a wavelength of 2780 nm in the treatment of purulent pulpitis. The patient was treated in one visit, aqua destillata was used with irrigation solution, the root canals of the teeth were sterilized with a hydrokinetic Er, Cr:YSGG laser Waterlase Iplus with a wavelength of 2780 nm with the parameters: power-1.5 W, frequency-40 Hz, air-35%, water-25%. Bacteriological examination after mechanical and laser treatment showed antibacterial decontamination of the root canal system of the tooth. According to the X-ray examination, 6 months after the treatment, there was no inflammatory process in the periodontal tissues. The use of a hydrokinetic Er, Cr: YSGG laser with a wavelength of 2780 nm in the treatment of complicated forms of dental caries is a reliable alternative to traditional endodontic treatment protocols, allowing you to reduce the amount of irrigation solutions used, intra-channel pastes, as well as initiate faster rehabilitation of patients after treatment.
EVALUATION OF THE QUALITY OF THE RESULTS OF ORTHODONTIC TREATMENT IN THE CLINICS OF ST. PETERSBURG
Authors: E.S. Vinogradova , S.I. Vinogradov
Published: September 2021

To date, various methods of qualitative and quantitative assessment of dental-facial anomalies have been described in the medical literature. They describe the causes of dental anomalies, determine the localization of disorders, consider the functional state of the dental system, as well as quantify the degree of violations of facial aesthetics, occlusion, morphology and function in various dental-facial anomalies. To assess the effectiveness of orthodontic treatment, it is necessary to conduct a quality assessment in patients with dentofacial anomalies who have completed orthodontic treatment. The essence of the proposed method is that on the basis of tables developed and structured according to several blocks, an assessment of the quality of orthodontic treatment is proposed, including an assessment of the aesthetics of the face and smile, articulation and occlusal ratios, malocclusion anomalies in the sagittal, vertical and transversal directions, the state of periodontal tissues and hard tissues of the teeth, as well as the state of the temporomandibular joint in patients who have completed orthodontic treatment. The assessment of the quality of orthodontic treatment consists of three blocks: assessment of the quality of the results of orthodontic treatment, assessment of the process of orthodontic treatment, assessment of the maintenance of medical records. According to the results of filling in which, a conclusion is made about the quality of the orthodontic treatment. The overall assessment of the quality of orthodontic treatment is obtained by summing up the results of the three assessments received, and the assessment of the quality of clinical work is crucial. The method developed by us allows us to make an expert assessment of the process of orthodontic treatment, the quality of its results and the maintenance of medical records in patients who have completed orthodontic treatment. The article presents the results of the assessment of the quality of orthodontic treatment in the clinics of St. Petersburg.
PROSPECTS FOR MANUFACTURING FRAMES OF METAL CERAMIC STRUCTURES OF DENTAL PROSTHESES BY THE METHOD OF SELECTIVE LASER SINTERING
Authors: V.A. Stepanov , V.I. Shemonaev , E.A. Buyanov , D.V. Grachev , A.N. Parchomenko , I.A. Zubreva
Published: September 2021

The article presents the results of evaluating the prototyping of metal-ceramic structures made by casting and selective laser sintering. To achieve this goal, 27 patients with fabricated metal-ceramic crowns and bridgeworks were examined. Two study groups were created. The first group included 14 patients for whom dental prosthesis frameworks were made by casting. The second group consisted of 13 people, for whom the frames of dentures were made by the method of selective laser sintering. The analysis of clinical effectiveness was carried out according to the following criteria: 1- precision of the felling of prosthesis frame to solid tissues of abutment teeth; 2- the condition of the marginal periodontium; 3- the integrity of the ceramic cladding. The results of the study showed that the precision to solid tooth tissues of metal-ceramic dental prostheses made by laser selective sintering is higher than of frames made by casting. In accordance to the second criteria the best results were also shown by the participants of the second group. No chipping of the ceramic veneer from the metal-ceramic denture frameworks made by laser selective sintering was found. Thus, dentures which frameworks are made by the method of selective laser sintering are characterized by a higher objective assessment of their precision to the solid tissues of the abutment teeth. Lesions of the marginal periodontium both inflammatory and dystrophic were less in the participants of the second group. The frequency of defects in the coating of metal-ceramic dentures was significantly lower in the case of fabrication frameworks by laser selective sintering.
ANALYSIS OF POPULATION SATISFACTION WITH THE QUALITY OF PROVIDING SERVICES ON PREMIUM MEDICINAL PROVISION
Authors: L.P. Ustinova , I.A. Filina , G.V. Varenyk , E.A. Maltsev
Published: September 2021

Drug therapy is one of the main components of medical care for the population, and the provision of drugs is an important indicator of its availability and quality. The purpose of our work was to analyze satisfaction with the quality of the provision of services for preferential drug provision. The works of domestic and foreign scientists in the field of preferential drug provision, as well as regulatory and organizational documentation on pharmaceutical activities were taken as an information base. The survey method served as the main research method. The objects of the study were the visitors of the pharmacy organizations of the Oryol region, who receive drugs under the program of preferential drug provision. The study found that 49.0% of respondents had difficulties in making an appointment with a doctor; cases of refusal to issue a prescription were indicated by 29.0% of the respondents; 45.0% of the respondents had to spend a long time on obtaining a preferential prescription for a drug by the decision of a medical commission. The majority of respondents (54.0%) do not receive medicines on preferential terms on time (postponed for more than 10 days). Almost half of the surveyed respondents (48.0%) are not satisfied with the treatment with prescription drugs prescribed under the program of preferential drug provision, due to the lack of drugs prescribed by a doctor in the pharmacy organization at the time of contact and their preference for drugs from other manufacturers. Most of the respondents (61.0%) consider the range of preferential drugs to be insufficient for the treatment of their underlying disease. Some respondents (20.0%) are not satisfied with the service in a pharmacy organization; 19.0% are dissatisfied with the quality and completeness of information about medicines received from a doctor and a pharmacy worker. The results obtained were communicated to the management of medical and pharmaceutical organizations serving privileged categories of citizens in the Oryol region. The authors of the study developed a Standard Operating Procedure “Procedure for Selling Medicines to Beneficial Categories of Citizens”, which helps to optimize the quality of service in pharmacies for the population receiving medicines under the preferential drug provision program.
TO THE QUESTION OF THE CARDIOVASCULAR RISK FACTORS IN MEN UNDER 50 YEARS OLD WITH MYOCARDIAL INFARCTION AND ARTERIAL HYPERTENSION
Authors: A.V. Gordienko , A.K. Davletova
Published: September 2021

Relevance. Myocardial infarction and its complications in young and middle-aged men with arterial hypertension remains an important problem of modern cardiology.
Aim. To evaluate the cardiovascular risk factors structure features in men under 50 years old with arterial hypertension to improve prevention and outcomes.
Material and methods. The study included 209 men aged 19-50 years old with type I myocardial infarction, who underwent a standard diagnostic algorithm in the first 48 hours and at the end of the third week of the disease. The patients were divided into two age-matched groups: with arterial hypertension (121 patients, 88 patients without arterial hypertension). A comparative analysis of the frequency of identifying the main and additional cardiovascular risk factors and their parameters were performed in the selected groups.
Results. The study group showed more pronounced glycemia (5.6±1.4 mmol/l) than in the control group (5.2±1.3 mmol/l; p=0.04) at the end of the third week of myocardial infarction. In this group, there was a high incidence of obesity (42.1 and 25.0%, respectively; p=0.01), changes in peripheral arteries (86.0 and 3.5%; p<0.0001) and target organ damage , meteorological dependence (31.4 and 9.1%; p=0.0001), impaired peripheral hemodynamics, as well as hereditary burden of vascular pathology (100 and 56.8%; p=0.03).
Conclusions. The data obtained suggest a worse long-term prognosis and a greater degree of resistance to treatment in men with arterial hypertension, which must be considered when implementing preventive programs.
HEART RATE AND CONDUCTIVITY DISORDERS FEATURES IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION AND RECURRENT ISCHEMIA
Authors: A.S. Balabanov , S.Yu. Epifanov , V.A. Reiza
Published: September 2021

Relevance. Heart arrhythmia in early postinfarction angina and recurrent myocardial infarction is negatively affected the prognosis of the disease.
Aim. To evaluate the peculiarities of heart rhythm and conduction disturbances and electrocardiographic (ECG) changes in men under 60 years old with early postinfarction angina and recurrent myocardial infarction for improve prevention and outcomes.
Material and methods. The study included men aged 19-60 years old with myocardial infarction type I. Patients were divided into two age-comparable groups: I - study group with recurrent episodes of ischemia (early postinfarction angina pectoris and / or recurrent MI) - 110 patients; II - control, without them - 555 patients. A comparative assessment of heart arrhythmias and electrocardiographic changes observation frequency in the selected groups was performed.
Results. In the patients of the study group more often than among all other patients, ventricular fibrillation was observed (8.5 and 3.9%, respectively; p = 0.04), paroxysmal supraventricular tachycardia (5.7 and 1.8%; p = 0.02) and electrocardiographic signs of the right atrium enlargement (9.4 and 1.6%; p ˂ 0.0001). In group I, among the deceased, electrocardiographic signs of left ventricular hypertrophy were more often detected (93.3 and 57.9%; p = 0.02). Arrhythmias that started in the subacute period of myocardial infarction were recorded with the same frequency in both groups of patients (1.4 and 1.6%; p = 0.9).
Conclusions. Men under 60 years old with recurrent episodes of ischemia in myocardial infarction are characterized by potentially curable ventricular fibrillation and supraventricular tachycardias. Electrocardiographic signs of left ventricular enlargement were an additional marker of a poor prognosis for these patients. The frequency of occurrence of "late" arrhythmias in this pathology is 1.4%, and the methods of their possible correction require clarification depending on the mechanism of their development.
THE LIPID METABOLISM IN YOUNG AND MEDIUM MEN AGE WITH MYOCARDIAL INFARCTION AND RECURRENT EPISODES OF ISCHEMIA
Authors: A.V. Golikov , S.Yu. Epifanov , V.A. Reiza
Published: September 2021

Relevance. Dyslipidemia is considered one of the main risk factors for the development of recurrent myocardial infarction and early postinfarction angina.
Aim. To evaluate the features of lipid metabolism in acute and subacute myocardial infarction in men under 60 years old with recurrent episodes of ischemia (recurrent myocardial infarction and/or early postinfarction angina) to search for new approaches to improve prevention measures.
Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent myocardial infarction - 68 patients; II - control, without it - 427 patients. A comparative assessment of lipid metabolism parameters and their dynamics in selected groups were performed.
Results. The study group differed in higher levels of total serum cholesterol (6.17±1.78 mmol/l) from the control group (5.56±1.28 mmol/l; p=0.02) at the end of the third week of disease, its dynamics during the observation period (I: 9.1%; p<0.0001; II: -1.8%; p<0.0001) and the dynamics of the atherogenic coefficient (I: -4.7.1; p=0.02; II: 6.3%; p<0.0001). In both groups, the group showed an increase in lipoproteins of low (I: 33.1; p=0.02; II: 45.5%; p<0.0001) and very low density (I: 275.8; p=0,0004; II: 233.4%; p<0.0001), atherogenic indices, decrease: triglycerides (I: -31.8%; p=0.02; II: -1.7%; p<0.0001) and high-density lipoproteins (I: -0.6%; p=0.02; II: -6.1%; p<0.0001).
Conclusions. The group with recurrent ischemia is characterized by more pronounced hypercholesterolemia at the end of the subacute period of myocardial infarction in comparison with the control group due to an increase in the concentrations of atherogenic lipid metabolism fractions. The dynamics of indices and the coefficient of atherogenicity during this period is multidirectional, which requires additional study.
DISTRIBUTION BY GENDER AND AGE OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS IN THE THERAPEUTIC DEPARTMENT OF THE CLINIC OF DENTISTRY OF THE MILITARY MEDICAL ACADEMY NAMED AFTER S. M. KIROV
Authors: A.M. Kovalevsky , V.V. Nikitenko , A.V. Potockaya
Published: September 2021

As an outpatient appointment, 347 patients (185 men and 162 women) who first sought dental care for chronic generalized periodontitis were examined in the therapeutic department of the Dentistry clinic of the Kirov Military Medical Academy. All patients were divided into three age groups: 40-45 years, 46-50 years, 51-55 years. There were no patients younger than 40 years old and older than 55 years old among the examined ones.
When analyzing the results of the examination of patients, it was revealed that the largest number of patients belongs to the age group of 40-45 years (49.3±2.7% of all examined), on the second place was the age group of 46-50 years – 127 (36.6±2.6% of all examined) people (p<0.001), the smallest the group of patients was 51-55 years, 49 (14.2±1.9% of all examined) people (p<0.001). There were no large differences in the number of patients by gender between the age groups (p>0.05). Mild chronic generalized periodontitis prevails among the examined patients (65.1±2.6%, p<0.001). The mild severity of chronic generalized periodontitis was recorded in 121 (65.4±3.5%) of the 185 men, among 162 women – in 106 (64.8±3.8%). Chronic generalized periodontitis of moderate severity was detected in 42 (22.7±3.1%) men and 38 (23.5±3.3%) women. Finally, 22 (11.9±2.4%) men and 19 (11.7±2.5%) women went to the therapeutic department of the dental clinic with severe chronic generalized periodontitis. Thus, there were no large differences between the sexes in the number of patients with different degrees of severity of chronic generalized periodontitis (p>0.05).
DISTANT TRACK OF ECOLOGICAL DISASTERS ON THE GENETIC-REPRODUCTIVE POTENTIAL OF GENERATIONS
Authors: N.V. Lazareva
Published: September 2021

The paper discusses and highlights the promising modern environmental problems that affect pollution and environmental destruction, affecting the health status of the population. The deterioration of the situation cannot be justified and compensated for by the positive results of the progress of civilization - today the decaying environment is gaining more and more weight even in comparison with the well-being and economic prosperity of developed countries, affecting the dynamics of the state of health. The studies carried out to determine the relationship between the development of psycho-somatic morbidity and environmental factors of environmental pollution are confirmed by a direct correlation dependence. Studies of the evolution of populations and species are described in detail under the increased pressure of mutations caused by pollution of the biosphere of an atomic and nuclear agent. However, until now, these studies have not been carried out with the required depth and scope. The proposed human genetic monitoring sets itself the task of determining the volume and dynamics of the hereditary health disorders in people caused by the influence of the genetic load. It has been proved that the main, methodologically, when working on genetic monitoring of a person is that an increase in the number of genetic pathologies in the population can be established only when reliable quantitative data are obtained. Thus, an absolutely acceptable solution to the contradictions between the quality of health and the state of the ecological situation has not yet been proposed.
NEUROMUSCULAR MANIFESTATIONS AND COMPLICATIONS OF COVID-19 INFECTION
Authors: L.R. Akhmadeeva , E.V. Izhbuldina , A.T. Khayrullin
Published: September 2021

In this paper, various neuromuscular manifestations of coronavirus infection are considered and methods of damage to the nervous system are highlighted. These include the "cytokine storm", impaired hemostasis, neurotropicity and neurovirulence of SARS-CoV-2. The persistence of the virus in the body affects the course of comorbid diseases, which requires a systematic approach to patient treatment. In this paper we discuss the data from modern research papers and clinical cases both from updated international literature and from our own clinical practice: it is the most frequently met condition - Guillain-Barré syndrome – acute inflammatory demyelinating polyneuropathy. We present both rare and common neuro-muscular conditions, their clinical onset, possible pathogenesis, variants of manifestation. According to the data from current publications, the evaluation and management of patients suffering from Guillain-Barré syndrome associated with new coronaviral infection SARS-CoV-2 is does not have major differences with the classical ones, that are not associated with the pandemic. Our patient that we present as our own case, was hospitalized, and observed as an in-patient. She was treated using plasma exchange in the algorithm of management. The outcome of this case was positive. We conclude that neuromuscular manifestation of new coronaviral infection SARS-CoV-2 could be new and possibly associated with this disease, but also could be described as worsening of the premorbid disorders. For instance, inherited neuromuscular diseases could have different variants during the period of pandemic caused by novel coronavirus SARS-CoV-2 infection.