bluuebunny/crossref_metadata_2025 huggingface dataset:
“Sonic Spaces for the Stray”: (Dif)Fusing Dis-location in Sound Installation and Performance
Authors: Andrea Parkins
Published: May 2023

This project examines subjectivity and its embodiment through the application of interactive electronics within sound installation and performance. It employs a merging of theory, method and practice that has not been fully researched to date and which represents a valuable addition to sound performance and electroacoustic composition.

My artistic research focuses on an ongoing series of improvisational/compositional experiments, moving between a dedicated workspace and sound production studios where I will work with acousticians, engineers, and programmers. The aim is to develop gestural/embodied approaches for applying interactive electronics within sound performance and fixed-media composition—mining tensions between failure and fluency; and diffusion strategies that highlight correspondences between embodiment, sound and space—emphasizing tensions between absence and presence.

Foundational research includes studying methods and applications for investigating spatialization and psychoacoustics, employed by artists including Maryanne Amacher. I will also study concepts/methods developed by artists such as George E. Lewis, focusing on interaction between algorithmically-based technology tools and physical gesture in musical improvisation. This research also engages with Julia Kristeva’s psychoanalytically-based writing on abjection and the sublime, grounding my studio-based research in theoretical inquiry that engages with subjectivity and embodiment. Supplementary research will address psychoacoustics, aural architecture, and spatialization theory and technologies.

The outcome of the project will be twofold: a body of sound installations and performances demonstrating an interactive approach to addressing relationships between the body, materiality, sound, space and situation; and a set of reflective writings that articulates the poetics and affective aspects of this multi-layered inquiry. The completed project will offer new knowledge production in the field of artistic research, and transmission of interdisciplinary knowledge to creative practitioners.
What's in a name? - The relation between pitch notation, note names and sight singing in different forms of pitch notation and in different ways of approaching pitch notation
Authors: Suzanne Konings
Published: May 2023

Sight singing is a part of almost every music theory curriculum in conservatoires. But one might ask oneself why lessons in sight singing are needed for students who can already read music notation? The answer usually is: to develop the aural imagination in relation to music notation. The way students have learned to read music notation in the first place did not develop this skill well enough then?

Experiences in teaching made me think that we need functional note names (unique sound names) to be able to aurally understand pitch in staff notation, and that the absolute note names (unique pitch names) may be an instrumentally useful, but less effective step ‘in between’ in the process of aural imagination. From existing literature and recorded tests with students performing special designed scores I hope to learn more about connecting the inner hearing world to music notation in the most effective way.
9 Lives of Piano
Authors: Eka Chabashvili  , Nino Jvania  , Tamar Zhvania
Published: May 2023

Since 2018, we have been conducting an artistic research that aims to research sound production techniques of piano in the 21st century. We have been inspired by the words of Karlheinz Stockhausen who declared, in 1992, that “piano music has come to an end and something quite different is coming… With the claviers made up to this time, there is nothing new to discover anymore.” The research resulted into a piece composed by a composer Eka Chabashvili in interaction with pianists Nino Jvania and Tamar Zhvania for 2 pianos, modified piano, video-installations and the virtual piano orchestra. The main aim of the piece “Has Piano Music Come to an End?” is to contradict Stockhausen and demonstrate various new possibilities of engaging acoustic piano in contemporary music.
In this exposition we offer two different presentations of the same artistic research introducing some of the research results employing, on one hand, academic and, on the other hand, creative writing styles.
Ofloxacin-loaded Selenium-tellurium Nanoheterojunctions for Skin Infection and Wound Healing
Authors: Gao Ping , Feng Sinuo , Wang Qinqi , Wang Ningning , Li Leijiao , Sun Jing , Shi Xincui , Zhou Bo , Li Wenliang
Published: May 2023

With the increasing antibiotic-resistant bacteria, antibiotic
treatment’s effectiveness has decreased, posing considerable threats to
public health. Synergistic therapy for bacterial infection has attracted
extensive attention due to its rapid, high efficiency and low toxicity.
This work synthesized high performance and bioactive selenium tellurium
nanoheterojunctions (TeSe) by one-step hydrothermal method. TeSe has
high photothermal conversion efficiency (81.4%) and excellent
photostability under 808 nm laser irradiation. Combined therapeutic
nanoplatform was constructed by loading with ofloxacin (OFLX) based on
TeSe nanomaterial as a NIR photothermal agent and carrier. Under
physiological conditions, a small amount of drug release was observed,
and NIR irradiation could effectively enhance OFLX release. In vitro
antibacterial experiments indicated that combined with antibiotic and
photothermal therapy had significant antibacterial activity against
gram-negative bacteria Escherichia coli (E. coli) and gram-positive
bacteria Staphylococcus aureus (S. aureus). In addition, animal
experiments further demonstrated that the combination therapy exhibited
excellent bactericidal activity and promoted wound healing of infection.
Such combined treatment strategy not only avoids damage to surrounding
tissues in PTT, but also reduces antibiotic use and delays the
development of antibiotic resistance. Therefore, this work reveals the
potential of antibiotic-photothermal combined therapy nanoplatform in
the field of antibacterial applications, providing a novel strategy for
the treatment of infectious diseases.
Profiling genome-wide methylation in two maples: fine-scale approaches to detection with nanopore technology
Authors: McEvoy Susan L. , Grady Patrick G. S. , Pauloski Nicole , Neill Rachel J. O’ , Wegrzyn Jill L.
Published: May 2023

DNA methylation is critical to the regulation of transposable elements
and gene expression and can play an important role in the adaptation of
stress response mechanisms in plants. Traditional methods of methylation
quantification rely on bisulfite conversion that can compromise
accuracy. Recent advances in long-read sequencing technologies allow for
methylation detection in real time. The associated algorithms that
interpret these modifications have evolved from strictly statistical
approaches to Hidden Markov Models and, recently, deep learning
approaches. Much of the existing software focuses on methylation in the
CG context, but methylation in other contexts is important to quantify,
as it is extensively leveraged in plants. Here, we present methylation
profiles for two maple species across the full range of 5mC sequence
contexts using Oxford Nanopore Technologies (ONT) long-reads. Hybrid and
reference-guided assemblies were generated for two new Acer
accessions: Acer negundo (65x ONT and 111X Illumina) and
Acer saccharum (93x ONT and 148X Illumina). The ONT reads
generated for these assemblies were re-basecalled, and methylation
detection was conducted in a custom pipeline with the published
Acer references (PacBio assemblies) and hybrid assemblies
reported herein to generate four epigenomes. Examination of the
transposable element landscape revealed the dominance of LTR
Copia elements and patterns of methylation associated with different
classes of TEs. Methylation distributions were examined at high
resolution across gene and repeat density and described within the
broader angiosperm context, and more narrowly in the context of gene
family dynamics and candidate nutrient stress genes.
Site effects removing and signal enhancement using dual-projection based ICA model
Authors: Hao Yuxing , Xu Huashuai , Xia Mingrui , Yan Chenwei , Zhang Yunge , Zhou Dongyue , Kärkkäinen Tommi , Nickerson Lisa , Li Huanjie , Cong Fengyu
Published: May 2023

Combining magnetic resonance imaging (MRI) data from multi-site studies
is a popular approach for constructing larger datasets to greatly
enhance the reliability and reproducibility of neuroscience research.
However, the scanner/site variability is a significant confound that
complicates the interpretation of the results, so effective and complete
removal of the scanner/site variability is necessary to realize the full
advantages of pooling multi-site datasets. Independent component
analysis (ICA) and general linear model (GLM) based harmonization
methods are the two primary methods used to eliminate
scanner/site-related effects. Unfortunately, there are challenges with
both ICA-based and GLM-based harmonization methods to remove site
effects completely when the signals of interest and scanner/site-related
variables are correlated, which may occur in neuroscience studies. In
this study, we propose an effective and powerful harmonization strategy
that implements dual-projection (DP) theory based on ICA to remove the
scanner/site-related effects more completely. This method can separate
the signal effects correlated with site variables from the identified
site-related effects for removal without losing signals of interest.
Both simulations and vivo structural MRI datasets, including a dataset
from Autism Brain Imaging Data Exchange II and a traveling subject
dataset from the Strategic Research Program for Brain Sciences, were
used to test the performance of DP-based ICA harmonization method.
Results show that DP-based ICA harmonization has superior performance
for removing site effects and enhancing the sensitivity to detect signal
of interest as compared with GLM-based and conventional ICA
harmonization methods.
CO 2 -scrubbing, zero gases, Keeling plots, and a new mathematical approach to ameliorate the deleterious effects of ambient CO 2 during 13 C-breath testing in humans and animals
Authors: McCue Marshall
Published: May 2023

C-Breath testing is increasingly used in physiology
and ecology research because of what it reveals about the different
fuels that animals oxidize to meet their energetic demands. Here we
review the practice of C-breath testing in humans
and other animals and describe the impact that contamination that
ambient/background CO in the air can have on the
accuracy of C-breath measurements. We briefly
discuss physical methods to avoid sample contamination as well as the
Keeling plot approach that researchers have been using for the past two
decades to estimate δ C from breath samples mixed
with ambient CO . Unfortunately, Keeling plots are not
suited for C breath testing in common situations
where 1) a subject’s VCO is dynamic 2) ambient [CO
] may change, 3) a subject is sensitive to
hypercapnia, or 4) in any flow-through indirect calorimetry system. As
such, we present a mathematical solution that addresses these issues by
using information about the instantaneous [CO ] and
the δ CO of ambient air as well as
the diluted breath sample to back-calculate the δ CO
in the CO exhaled by the animal. We
validate this approach by titrating a sample of
C-enriched gas into an air stream and demonstrate
its ability to provide accurate values across a wide range of breath and
air mixtures. Researchers can now instantaneously calculate the δ
C of alveolar gas of humans or animals in real time
without having to scrub ambient CO or rely on
estimated values.
BOOTSTRAPPING THE P300 IN APPLIED PSYCHOPHYSIOLOGY: EVALUATING PRECISION IN DIAGNOSTIC TESTS
Authors: Olson Joseph , Subramanian Gayathri , Wojciechowski Jerzy , Bitegeko Celine , Rosenfeld J. Peter
Published: May 2023

Background: In applied psychophysiology, bootstrapping procedures are
often used to classify individuals into one of two or more independent
states (e.g., high risk vs low risk). Although the number of iterations
required for a reliable bootstrap test is not universally agreed upon,
some research (Rosenfeld et al., 2017b) suggests that 100 iterations is
a sufficient number to obtain reliable results when analyzing P300 from
a concealed information test. However, no study to-date has evaluated
the diagnostic consistency of the 100 iterations test across repeated
examinations. Methods: We evaluated the precision of the 100 iteration
test by repeating the test 100 times per participant in a sample of 81
participants. The test was designed to classify participants as either
knowledgeable or not knowledgeable of critical information related to a
mock crime. Results: We found that the test provided variable
classifications in approximately a quarter of our sample (n = 19/81 or
23%), specifically when a participant’s score presented near the
diagnostic cutpoint. Moreover, the test’s diagnostic results varied by
as much as +/-15%, in certain cases. Conclusion: Although the test
provided reliable results for the majority of our sample, this was not
true for a notable number of cases. We recommend that researchers report
the variability of their diagnostic metrics and integrate this
variability when classifying individuals. We discuss several simple
examples of how to take variability into account when making
classifications, such as by calculating the probability of one
classification state over another given the data.
Visible covalent click chemistry via macroscopic gel assembly
Authors: Zheng Yinglin , Ke Zhihai
Published: May 2023

Macroscopic ‘click’ covalent assembly using azide/alkyne functionalized
polymer hydrogels was studied. It is achieved by amplifying
chemoselective alkyne-azide click reaction through interfacial multisite
interactions. The underlying LEGO-like building process could be
generalized with the help of click chemistry. Macroscopic assembly of
hydrogels via host–guest chemistry or non-covalent interactions such as
electrostatic interactions has been reported. Unlike macroscopic
supramolecular assembly, here we report visible ‘click’ covalent
assembly of hydrogels at macroscale. PAAm hydrogels modified with alkyne
and azide groups, respectively, can click together via formation of
covalent bonds. Monomer concentration-dependent assembly and selective
covalent assembly have been conducted. Notably, macroscopic gel assembly
clearly elucidates the substrate selectivity not observed in the
solution reactions of competing monomers.
J&S Publisher Problems: A Diagnostic Analytics Case Exploring Employee Expense Reimbursement
Authors: Hoelscher Jamie , Shonhiwa Trevor
Published: May 2023

This paper aims to help students further understand employee reimbursement schemes, while simultaneously advancing the integration of data analytics in the accounting curriculum. The learning activity takes students through a comprehensive data analytics cycle to determine the root cause of employee expense reimbursement increases. The ability to leverage data analytics and possess technological agility to address business questions is an important skillset. Our paper contributes to the literature by presenting a resource that promotes the acceleration of integrating data analytics across the curriculum. The case topic is applicable to many classes, including audit (both external and internal), accounting information systems (AIS), financial, or forensic accounting, thereby promoting compliance with new accreditation standards requiring analytics throughout the curriculum. This case study helps expand the coverage of data analytics and learning experiences that emphasize the integration of information technology in the accounting curriculum.

JEL Classifications: M40; M41; M42.
Owner Exposure through Firm Disclosure
Authors: Müller Maximilian A. , Peter Caspar David , Urzúa I. Francisco
Published: May 2023

We study whether firms avoid financial disclosures to preserve their owners' financial privacy. We find that firms named after their owner, for whom firm disclosure would more directly expose owner information, are more opaque. Eponymous owners prefer firm opacity when disclosure exposes sensitive owner information with social stigma, in rural and anticapitalist areas, and in insider-oriented settings with high secrecy and distrust. When firms are forced to disclose, eponymous owners more frequently change their firms' names, and new firms are less frequently named after their founding owners. These findings indicate that owner-level privacy concerns dampen firm-level disclosure incentives.

Data Availability: The data used in this study are available from public sources listed in the paper.

JEL Classifications: D82; L51; M41.
PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ
Authors: Zhong Yi , Wang Yilong , Li Xiaoguang , Qin Haojie , Yan Shu , Rao Caijun , Fan Di , Liu Duqiu , Deng Fei , Miao Yanli , Yang Ling , Huang Kai
Published: May 2023

Obesity is a global health threat, and the induction of white adipose tissue (WAT) browning presents a promising therapeutic method for it. Recent publications revealed the essential role of protein arginine methyltransferase 4 (PRMT4) in lipid metabolism and adipogenesis, but its involvement in WAT browning has not been investigated. Our initial studies found that the expression of PRMT4 in adipocytes was upregulated in cold-induced WAT browning but downregulated in obesity. Besides, PRMT4 overexpression in inguinal adipose tissue accelerated WAT browning and thermogenesis to protect against high-fat diet–induced obesity and metabolic disruptions. Mechanistically, our work demonstrated that PRMT4 methylated peroxisome proliferator-activated receptor-γ (PPARγ) on Arg240 to enhance its interaction with the coactivator PR domain-containing protein 16 (PRDM16), leading to the increased expression of thermogenic genes. Taken together, our results uncover the essential role of the PRMT4/PPARγ/PRDM16 axis in the pathogenesis of WAT browning.

Article Highlights

Protein arginine methyltransferase 4 (PRMT4) expression was upregulated during cold exposure and negatively correlated with body mass of mice and humans. PRMT4 overexpression in inguinal white adipose tissue of mice improved high-fat diet–induced obesity and associated metabolic impairment due to enhanced heat production. PRMT4 methylated peroxisome proliferator-activated receptor-γ on Arg240 and facilitated the binding of the coactivator PR domain-containing protein 16 to initiate adipose tissue browning and thermogenesis. PRMT4-dependent methylation of peroxisome proliferator-activated receptor-γ on Arg240 is important in the process of inguinal white adipose tissue browning.
CRIMINALIZATION POLICY ON THE ACT OF MAKING, PRODUCING, AND TRADING ILLEGAL FISHING CAPTURE EQUIPMENT
Authors: Farida Ida , Katimin Herman
Published: May 2023

The widespread use of illegal fishing capture equipment in the form of drag nets and drag nets which harm and endanger the sustainability of fish resources and the environment in Indonesian waters, cannot be separated from the act of making, producing, and trading. The research method used is a sociological juridical approach which is qualitative in nature, where this research uses a normative approach with a sociological approach as support. Based on the results of the research, criminalizing the act of making, producing, and trading becomes a crime, formulated in article 85A, which reads "Whoever deliberately brings, produces and trades illegal fishing equipment or illegal fishing aids that are not in accordance with the provisions referred to in Article 7 shall be punished with a maximum fine of Rp. 250,000,000.00 (two hundred and fifty million rupiah)”. So that law enforcers comprehensively apply the elements of the intended crime, including proving the elements of intentional wrongdoing, Actus Reus and Mens Rea, as well as excuses that eliminate a crime.
THE IMPACT OF LOCAL POTENTIAL-BASED COMMUNITY EMPOWERMENT THROUGH THE TOURISM VILLAGE PROGRAM IN CIKOLELET VILLAGE, CINANGKA DISTRICT, SERANG-BANTEN REGENCY
Authors: Risdawati Risdawati , Hermansah Tantan
Published: May 2023

There are several ways to empower rural communities, one of which is through tourism. The community can benefit from their expertise in managing natural resources, such as processing coffee beans into ground coffee, which will become the village's trademark. The Cikolelet Tourism Village, located in Cinangka District, Serang Regency, Banten, is expected to alleviate poverty by reducing unemployment, inequity, and job creation. Furthermore, it has the potential to benefit coffee farmers and the surrounding community. The purpose of this study is to describe the Cikolelet Village Government's contribution to the local potential-based tourism village program and to analyze the impact of the tourism village program. The qualitative approach was used in this study, with data obtained through observation, interviews, and documentation studies. The research data sources are primary and secondary data sources, and the data analysis techniques are those proposed by Miles and Huberman. The study's findings indicate that the tourism village program needs to be implemented optimally. However, the tourism-supporting sector, specifically coffee production under the Cikopi brand, has achieved independence and is no longer dependent on the tourism village program. The community felt the impact of the public awareness always to protect the environment and capitalize on the local potential. Income is increasing, coffee productivity is rising, and the community can contribute adequately.
Properties of Pineapple Leaf Fibers with Paper Waste as An Absorbing-Composite to Reduce Noise
Authors: Sari Kartika , Isnen Yazid Zainur , Utomo Agung Bambang Setio , Sunardi Sunardi
Published: May 2023

Natural product-based noise-absorbing composite can be an alternative to replace synthetic fiber because of its advantages of high strength, toughness, low price, and abundance to reduce noise. The materials used were pineapple leaf fibers with paper waste. This research aims to study the advantage of natural products to reduce noise by analyzing the coefficient of sound absorption and impact strength to evaluate the absorbing composite. The composites were tested with the Charpy method with ISO 11654 standard and ASTM E23 for sound absorption and impact strength. Sound absorption was carried out using an impedance tube at a frequency range of 250 – 3000 Hz. The volume fraction of pineapple leaf fibers, paper waste, and resin epoxy concentrations were 20% : 30% : 50%, 25% : 25% : 50%, and 30% : 20% : 50%. The thickness for the sound absorption coefficient was 2 cm and 3 cm, while the thickness of the impact strength was 0.5 cm. The highest sound absorption coefficient of pineapple leaf fibers composite for 30% : 20% : 50% volume fraction was 0.788 for sample 2 cm. The highest impact strength for 20% : 30% : 50% volume fraction of the thickness of 0.5 cm was 3.527 J/mm2. The results of the sound absorption coefficient will increase if used more pineapple leaf fibers but it will decrease the impact strength. Based on this research, the pineapple leaf fibers will improve the quality of the composite that can be used as a sound-absorbing material as well. These materials possess the promising potential to decrease waste and are used in industries for a low cost.
Optimization of Oxygen Flow Valve Holes in Small Industrial Scale Husk Furnaces
Authors: Hajar Siti , Har Nazopatul Patonah , Irmansyah Irmansyah , Arif Ardian , Irzaman Irzaman
Published: May 2023

The increasing use of fossil-based fuels causes an imbalance between energy demand and the availability of that energy. Therefore, the use of rice husk biomass as alternative energy was implemented through the use of rice husk furnaces. This research aims to optimize the efficiency of a small industrial-scale husk furnace by varying the oxygen flow valve holes and the mass of the heated water. The test on the husk furnace was carried out using the Water Boiling Test (WBT) method with the following test parameters: combustion time, FCR, input power, output power, power loss, radiant energy, and thermal conductivity of the pan and chimney of the husk furnace. Tests were carried out on four variations of the oxygen flow valve holes (horizontal: 18 x 36 cm2 and 27 x 36 cm2, vertical: 27 x 24 cm2 and 27 x 12 cm2) and three variations in the mass of heated water (6 kg, 12 kg, and 18 kg). The highest efficiency of the husk furnace was obtained at 18 kg of water, and based on each test parameter, the performance of the husk furnace was most optimal at the horizontal valve hole measuring 27 x 36 cm2 with an average efficiency of 17.32%.
Contesting identity through the market: Tourism and indigenous movement in Kasepuhan Ciptagelar, West Java
Authors: Widiyanto Nur , Widyaningsih Rindha , Suhartapa
Published: May 2023

This study identifies the interplay between the engagement of Kasepuhan Ciptagelar, an indigenous community inhabiting the state forest in West Java, and tourism development in the area. Practising local spirituality rooted in an indigenous belief, tatali paranti karuhun, while administratively accepting Islam, the people have been struggling to deal with the nearby majority Sundanese who practices Islam and the establishment of the national park covering their living space. The study considers whether a minority group living in an area endowed with both natural and cultural tourism resources consciously chooses tourism as a selected ground to deal with policies which neglect them in terms of religious practices and land policy. Employing the ethnographic method, the study reveals that contesting identity in tourism also means the readiness to accommodate various outside elements. However, the strategy has led the Halimun Salak National Park authority to declare the area as a “special status area” for cultural tourism inside the state park since 2017. The study findings show that after engaging with tourism, various rituals and art performances rooted in the old Sundanese spirituality, which is not officially recognized by the state, can be freely performed for the sake of tourists. In this case, the community is not passive in dealing with external forces but has also enabled its own silent productivity, including its varying consequences.
JUVENILE GRANULOSA CELL TUMOR OF THE OVARY IN A CHILD: CLINICAL CASE AND BIBLIOGRAPHICAL REVIEW
Authors:   Morozov Children’s City Clinical Hospital, Moscow, Russia, Bezdolnova E.O. , Kubirov M.S. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Kirillov A.A. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Gorev V.V. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Kumirova E.V. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia
Published: May 2023

Juvenile granulosa cell tumor of the ovaries is a rare disease in pediatric oncology. Mostly seen in girls and young women in premenarchal age (median age 10 y/o) and is more aggressive than the adult type, but has a favorable prognosis, especially in its early stages. Large reviews and studies include patients with bot adult and juvenile types granulosa cell tumor. Due to the limited cohort of pediatric patients, there are no standards for the treatment of juvenile granulosa cell tumor in pediatric practice. Therefore, diagnosis, treatment, and long-term follow-up for this disease are based on recommendations for an adult cohort. Adjuvant chemotherapy as a curative option is used in advanced stages above the FIGO IC. For the IC stage, the issue of prescribing adjuvant chemotherapy remains debatable. Article represents analysis of the bibliographical data of the largest studies on the treatment of this disease as well as clinical case of a 15 y/o patient with juvenile granulosa cell tumor of the right ovary who had received complex treatment in the Oncological Department of the Morozov Children’s City Clinical Hospital (Moscow, Russia).
REACTIVE BLOOD CHANGES IN THE PRACTICE OF PEDIATRIC PHYSICIAN, ONCOLOGIST AND HEMATOLOGIST: BIBLIOGRAPHICAL REVIEW AND CLINICAL CASE
Authors:   Research Institute of Pediatric Oncology and Hematology named after Academician L.A. Durnov with the N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Klyut A.S. , Valiev T.T. ,   Research Institute of Pediatric Oncology and Hematology named after Academician L.A. Durnov with the N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Belysheva T.S. ,   Research Institute of Pediatric Oncology and Hematology named after Academician L.A. Durnov with the N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Malikhova O.A. ,   Research Institute of Pediatric Oncology and Hematology named after Academician L.A. Durnov with the N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Nasedkina T.V. ,   Laboratory of Biological Microchips with the V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia, Gusarova O.A. ,   Research Institute of Pediatric Oncology and Hematology named after Academician L.A. Durnov with the N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Kirgizov K.I. ,   Research Institute of Pediatric Oncology and Hematology named after Academician L.A. Durnov with the N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Varfolomeeva S.R. ,   Research Institute of Pediatric Oncology and Hematology named after Academician L.A. Durnov with the N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Published: May 2023

Reactive blood changes are a heterogeneous group of pathological conditions that can occur in response to various conditions: viral, bacterial infections, helminth toxins, allergic agents. These reactions often require differential diagnosis with malignant neoplasms (MN) of the blood and hematopoietic organs (leukemias, lymphomas). It is important to note that only with a comprehensive examination of the patient with the involvement of a pediatric oncologist and hematologist, it is possible to exclude MN and carry out etiotropic treatment that contributes to the normalization of hemogram parameters. Article represents current data on the etiopathogenesis of leukemoid reactions, reactive thrombocytosis, secondary erythrocytosis and a clinical case observation of the development of a pseudoblast leukemoid reaction and reactive thrombocytosis against the background of an infectious process in a patient with Peutz-Jeghers syndrome, which will be of use to a wide range of pediatric practitioners.
LANGERHANS CELL HISTIOCYTOSIS IN TWINS: BIBLIOGRAPHICAL REVIEW AND CLINICAL CASE
Authors:   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Fominykh V.S. , Batmanova N.A. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Valiev T.T. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Nazarenko I.A. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Kirgizov K.I. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Varfolomeeva S.R. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Published: May 2023

Langerhans cell histiocytosis (LCH) is the most common histiocytic disorder in children and is characterized by clonal expansion of myeloid precursors. The pathological cells are morphologically and phenotypically similar to Langerhans cells. LCH is considered as a sporadic disease as yet with undescribed hereditary factors for its development. However, hereditary predisposition to the development of this pathology cannot be excluded. There are cases of the LCH development in twins described, both in monozygotic and dizygotic. Article represents bibliographical review on the familial forms of Langerhans cell histiocytosis and clinical case of the Langerhans cell histiocytosis development in twin girls.
ANALISIS DEBIT BANJIR DAERAH ALIRAN SUNGAI (DAS) SAMPEAN BONDOWOSO JAWA TIMUR
Authors: Prasetyo Angga , Prawati Eri , Surandono Agus
Published: May 2023

Daerah Aliran Sungai (DAS) suatu kawasan yang dibatasi oleh titik-titik tinggi di mana air yang berasal dari air hujan yang jatuh, terkumpul dalam kawasan tersebut. Air pada DAS merupakan aliran air yang mengalami siklus hidrologi secara alamiah, sirkulasi air yang tidak pernah berhenti dari atmosfer ke bumi dan kembali ke atmosfer melalui kondensasi, presipitasi, evaporasi dan transpirasi. Selama berlangsungnya daur hidrologi, yaitu siklus air dari permukaan laut ke atmosfer kemudian ke permukaan tanah dan kembali lagi ke laut. Proses terjadinya siklus hidrologi dibedakan menjadi 3 (tiga) yaitu siklus pendek, siklus sedang dan siklus panjang. Debit banjir rancangan merupakan debit banjir terbesar tahunan dengan suatu kemungkinan terjadi kala ulang tertentu, atau debit dengan suatu kemungkinan periode  ulang  tertentu. Dalam menghitung Analisis Debit banjir rancangan pada penelitian DAS Sampean Kabupaten Bondowoso Jawa Timur yang memiliki luas daerah sebesar 1254,48 km2 dengan panjang sungai 35,12 km dilakukan perhitungan hidrograf banjir dengan metode Hidrograf Satuan Sintetik Nakayasu.

Hasil perhitungan debit banjir rancangan menggunakan HSS Nakayasu di dapat nilai sebesar kala ulang 2 tahun adalah 7759,08 m3/detik, untuk kala ulang 5 tahun adalah 9773,87  m3/detik, untuk kala ulang 10 tahun adalah 11534,87  m3/detik, untuk kala ulang 25 tahun adalah 14273,82 m3/detik, untuk kala ulang 50 tahun adalah 16652,00 m3/detik, untuk kala ulang 100 tahun adalah 19572,58 m3/detik, untuk kala ulang 200 tahun adalah 22875,96 m3/detik, dan  untuk kala ulang 1000 tahun adalah 32903,04 m3/detik.
ANALISIS TATA RUANG PARKIR RUMAH SAKIT MARDI WALUYO KOTA METRO
Authors: Gufron Fakhri M , Sriharyani Leni , Hadijah Ida
Published: May 2023

Pada area parkir Rumah Sakit Mardi Waluyo pun, masih menggunakan tempat parkir yang seharusnya diperuntukkan untuk parkir, contohnya pada pintu masuk UGD (Unit Gawat Darurat), yang memang di peruntukkan untuk pasien yang harus mendapatkan penanganan medis yang cepat, tetapi dengan adanya parkir yang menutupi pada pintu masuk ruang UGD sangat menghambat pasien yang seharusnya membutuhkan penanganan cepat. Pola tata ruang parkir di Rumah Sakit Mardi Waluyo, masih banyak ditemukkan pola parkir / pemodelan parkir yang berbeda – beda yang masih memungkinkan bisa menjadi penyebab terjadinya penumpukkan kendaraan parkir pada Rumah Sakit Mardi Waluyo Kota Metro.

Dari analisis tata ruang parkir rumah sakit mardi waluyo kota metro untuk karakteristik ruang parkir akumulasi parkir roda dua didapat pada hari senin 241 kendaraan dan roda empat didapat pada hari selasa 108 kendaraan, durasi parkir didapat lamanya waktu parkir untuk roda empat terdapat pada hari selasa yaitu 138,42 menit dan roda dua terdapat pada hari rabu 175,41 menit, kapasitas parkir kend/jam didapat hasil terbesar untuk roda empat terdapat pada hari senin 90,93 kend/jam dan roda dua pada hari selasa 52,60 kend/jam. Ketersediaan parkir untuk roda empat terdapar pada hari selasa 1134 kend dan roda dua terdapat pada hari rabu 1438 kend. Indeks parkir didapat hasil terbesar untuk roda empat pada hari selasa 97,2% dan roda dua terdapat pada hari senin 217,1%, untuk turn over pada roda empat terdapat pada hari selasa 0,47 PTO dan roda dua terdapat pada hari senin 0,79 PTO, kebutuhan ruang parkir didapat hasil  perhitungan untuk roda empat 732 SRP dan roda dua 1377 SRP, untuk pola sudut parkir Rumah Sakit Mardi Waluyo Kota Metro masih dikatakan cukup dengan menggunakan pola sudut parkir sebelumnya yaitu 45°.
KARAKTERISTIK MARSHALL CAMPURAN ASPHAL CONCRETE –BINDER COURSE (AC-BC) DENGAN BAHAN PENGISI (FILLER) ABU BATU KAPUR (LIMESTONE)
Authors: Vianda Merza Okta , Sriharyani Leni , Kurniawan Septyanto
Published: May 2023

Jalan   merupakan   sarana   yang   sangat   penting   digunakan   untuk transportasi bagi masyarakat. Di Indonesia , kontruksi jalan sudah banyak menggunakan campuran Laston, karna dalam campuran ini akan menghasilkan lapisan perkerasan yang kedap air dan tahan lama, harga relatif murah dibandingkan dengan kontruksi jalan beton. Dalam penelitian ini dicoba menggunakan variasi filler berupa abu batu kapur (Limestone) sebagai alternatif bahan campuran lapis aspal beton AC-BC. (Limestone) sendiri banyak dijumpai di provinsi Lampung, Khususnya di Kabupaten pesawaran yang sebagian besar digunakan untuk bahan bangunan. Jenis  penelitian  ini  adalah  penambahan  variasi  filler (Limestone) kedalam campuran AC-BC dengan penambahan komposisi campuran sebesar 0% (tanpa bahan tambahan), 1%, 2%, 5%, 6% dan kadar aspal 4,5%, 5%, 5,5%, 6%, 6,5%. Hasil penelitian ini menunjukan bahwa karakteristik Marshall seperti nilai VMA, VFA cenderung naik sedang nilai VIM, Flow, Stability, Marshall Quotient cenderung menurun karena pengaruh variasi filler. Di dapat KAO sebesar 5%, 5%, 5,1%, 5,5%, 5,6%, 5,8%, 5,9%, dan 6,4%. Berdasarkan spesifikasi Bina Marga 2010 di dapat penambahan variasi filler 1%, 2% dengan KAO 5,5%..
Studying influence of different impurities on foaming of amine absorbents of sour gas treatment plants
Authors: Gibadullin Ruslan Faritovich , Chudievich Dariya Alekseevna
Published: May 2023

The article focuses on studying the foaming process in the amine solutions (diethanolamine (DEA) and methyldiethanolamine (MDEA)) on an example of the model mixtures containing different organic and inorganic impurities and their combinations: oxalic acid, formic acid, corrosion inhibitor, hydrocarbons, amine decomposition products, mechanical impurities. It has been found that the greatest influence on foaming in the DEA solution is exerted by its decomposition products containing the formic acid, and at a concentration of 3% by weight the foam height increased by more than 3 times, and the foam stability - by 20 times. Oxalic acid also has a significant effect on foaming: at a concentration of 1 g/l the foam height increased by 3 times, and the foam stability - by more than 5 times. The decomposition products of DEA containing oxalic acid have a rather noticeable effect - the height and stability of the foam increased by 2.8 and 6.8 times, respectively. The foam grew least in the presence of formic acid - by 2 times, at the same time the stability was enhanced by more than 4 times. It has been stated that hydrocarbons have the greatest influence on foaming of the MDEA solution - at a concentration of 0.5% vol. the foam height increased by more than 1.7 times, and the stability of the foam - by 5 times. Similarly, the decomposition products of MDEA made a significant impact – the foam height increased by more than 1.7 times, and the foam stability - by 11 times. Mechanical impurities caused an increase in the foam height by more than 1.6 times and in stability by 1.4 times. Introducing a corrosion inhibitor foaming gave the least result - the foam height decreased by 2.8 times, and the stability increased by 2 times. There has been found the mutual influence of impurities in the MDEA solution, which could be seen in the mutual suppression of foaming in the double and triple mixtures compared with the single-component solutions.
Modernization of equipment for transportation of polypropylene
Authors: Memedeykina Nataliya Pavlovna , Telichkina Elvira Rafaelevna , Klimov Nikolay Nikolaevich
Published: May 2023

The article considers the operation principle of the Roots-type gas blowers. The diagram of the airflows from the blower is illustrated. A detailed description of the technological process of gas compression is given. The main actual defects of equipment such as blowers during operation are listed. Repair of equipment includes, as a rule, dismantling, complete disassembly of the flow part of the case and impellers with cleaning from the polymer, replacement of the rotary piston, cleaning tensioned metal points, replacement of rolling bearings and seal rings, as well as turning and mechanical works. The reasons for the defects are considered. Industrial rotary gas blowers transport polypropylene (powder) for its further processing in an adjacent production shop and are important for the shop operation as a whole. During operation, when the ambient temperature exceeds 40°C, heating of the parts and mechanisms of the gas blower exceeds 85°C, which affects the operation of the equipment. It is proposed to use the throttle effect to reduce the gas temperature at the suction stage of the gas blower without using the heat exchange equipment in the technological process. The principle of the Joule-Thompson throttle effect is described. Physical substantiation of the temperature effect of throttling is given, which consists in the ratio of changes in the internal kinetic and internal potential energy of the gas flowing. An inversion curve plot for nitrogen is shown. A list of measures for the maintenance and repair of equipment for pneumatic transportation of polypropylene (powder) is presented.
Studying reaction of erect marigolds (Tagetes erecta) to oil pollution
Authors: Stepanenko Elizaveta Aleksandrovna , Volkova Irina Vladimirovna , Alferova Viktoriya Aleksandrovna , Seydalieva Leila Kamidullaevna
Published: May 2023

The article focuses on studying the reaction of erect marigolds (Tagetes erecta) on oil pollution of the soil and presents the results on germination, shoot length, root length, death of seedlings and morphological changes. The study results were shown using model contaminated soils (concentrations of 2.5 g/kg, 5 g/kg and 7.5 g/kg) in parallel with the control (clean soil). The studies were carried out under equivalent conditions (similar grade of soil, temperature regime, light level, humidity, etc.). It was found that the results of germination in combination with the results of death and morphological changes are most significant for this test object. At low and medium concentrations of oil (2.5 g/kg and 5 g/kg) there is registered an increasing percentage of germination, and at high concentrations (7.5 g/kg) there is a decrease. At concentration of 5 g/kg, along with increasing germination, the subsequent death of seedlings (2%) is observed. And at concentration of 7.5 g/kg, in addition to a decreasing germination, there is registered an increasing death (4%) and specific morphological changes (signs of chlorosis). It was stated that the optimal concentration of contamination is 5 g/kg, at which the percentage of germination increases, the length of the stem grows and the length of the root decreases slightly. At such level of pollution plants are not subject to significant negative changes (death losses are minimal - 1 seedling), which indicates the tolerance and adaptability of this object to certain concentrations and makes it possible to use it in the future as an object of phytoremediation.
Digital Generation - Analysis of the Use of ICT by Young Poles
Authors: Stanimir Agnieszka
Published: May 2023

In the Europe 2020 strategy in area of smart growth one of the flagship initiatives is Digital Agenda for Europe. Implementation of this initiative will lead to wide-availability of ICT solutions to society. Young people belonging to Generation Y most often treat the computer as a natural household equipment. Regular use of the Internet is very popular among them. They increasingly use mobile solutions in the field of ICT. The intelligent use of information technology possibilities will lead to sustainable economic growth. The purpose of the study was to cheque changes in the use of ICT among young Poles, and whether related behavioural patterns are similar in other countries of the European Union. The paper concludes with main reasons differencing generations in Poland due to the using the Internet.
A Research Study on Vibrating Elements and Consuming Electricity in Predictive Maintenance
Authors: Erol Salih Seçkin
Published: May 2023

Mechanical looseness is one of the common failures detected on machines and mechanical systems. In this research, resonance effect that is a problem for mechanical systems has been studied within perspective of mechanical looseness failure through a bearing. A test setup has been designed, built and located in laboratory environment. A bearing in the electrical motor, that is one of the elements in the test setup construction, has been chosen for acquiring data throught acoustic, vibration and electrical consumption during the test. The purpose of this research is testing condition monitoring of mechanical looseness failure and resonance for studying comparison of different predictive maintenance perspectives. The test was implemented at the electricity frequency of 40.5 Hz that forced the electrical motor through identified rotation speed. According to the analysis results, inspecting of mechanical looseness failure and resonance problem has been detected as the most effectively by vibration analysis.
Implementing a Simulation Model for the Evaluation of BGP Updates Impact on Real-Time Applications
Authors: Hoxha Ledina
Published: May 2023

Border Gateway Protocol (BGP) is the actual routing inter-domain protocol in the Internet. The size, heterogenity and changebility that characterize todays Internet put always increasing requirements on BGP performance. The research community has already reported the unwanted characteristics of BGP like low integrity and slow convergence through theoretichal analyzes andd empirical measurements. Simulations allow for more realistic and flexible experiments than the theoretichal approach and also lower costs than the measurements in real life environments. The first part of this work describe theoretically characteristics and problems related to BGP nd also expectations of the today Internet users to real time applications (like VoIP). The second part concentrates in identifying and implementing of the elements for creating an integrated simulation environment for evaluating dhe effects of slowconvergence of BGP in these applications. At last it is evaluated the created environement through some small scale simmulations that try to model the now days Internet Structure.
Mandatory COVID-19 Vaccination and Free Self-Determination in the Health Field in Italy
Authors: Furramani Emanuela
Published: May 2023

The COVID-19 pandemic and the issues related to health emergency management have raised concerns about fundamental rights protection. One of the most complex and contentious issues in doctrine and jurisprudence is the introduction of mandatory COVID-19 vaccination for specified categories of subjects, such as healthcare workers and individuals of a specific age range, as occurred in Italy. The debate in Italy over the mandatory COVID-19 vaccination requirement focuses on whether this obligation interferes with the individual’s fundamental right to free self-determination as guaranteed by Article 32 of the Italian Constitution. In jurisprudence and doctrine, conflicting opinions are noted concerning this topic. Part of the doctrine argue that mandatory COVID-19 vaccination compromises some fundamental rights guaranteed by the Italian Constitution, such as the right to free self-determination and respect for human dignity. Other opinions find the basis of the vaccination in the community’s best interests, citing Article 32 of the Italian Constitution, which allows for the imposition of compulsory health treatment to safeguard citizens’ health. In this regard, the issue of mandatory COVID-19 vaccination requires a reflection on the balance of two fundamental rights: the individual right to free self-determination and the community’s interest in terms of protecting public health.