bluuebunny/crossref_metadata_2025 huggingface dataset:
English Language Learning on Cultural Studies of Western United States Scholars Through Online Media
Authors: Shen Zijun
Published: July 2023

The journal investigates the published works in the academic areas with analysis on the generic abstracts on cultural form of linguistic and its influence on learning English language on cultural studies through online media on higher learning students. More particularly, it analyses the cultural settings on the language learning, as well as the linguistic resources applied in the realization of the based move in linguistic abstract studies. The linguistic micro-analysis has established a couple of constituents or rather moves by ways through which the schematic forms of research abstracts are developed. A number of these are obligatory inclusive of the moves pronouncing the current studies or pin pointing the article aims, introducing hypotheses, summarizing results and publishing the study methodology. Consequently, the cultural learning in the form of linguistic and its influence on learning English language through online media has portrayed some moves like five in numbers upon which Das are developed. Three of these are termed as obligatory, viz, the moves of purpose, the research methodology and results and discussions. Ideally, results present the prevalence of the application of mere sentences type, present tense in conjunction with the passive voice un the development of the abstract analysed context. In the context of the findings, some of pedagogical subjects recommended. Cultural studies by online media is one of the factors currently in the classroom that tutors and leaners in English language (EL) in the higher learning institution can apply in practical ways.
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Authors: Højgaard Kristoffer , Szöllősi Bianka , Henningsen Kim , Minami Natsumi , Nakanishi Nobuhiro , Kaadt Erik , Tamura Makoto , Morris Richard , Takeuchi Tomonori , Elfving Betina
Published: July 2023

Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-hippocampal circuit. It is associated with the expression of activity-dependent genes that may mediate initial or cellular memory consolidation. Several genes have been identified to date, however, to fully understand the mechanisms of memory consolidation, additional candidates must be identified. In this cross-species study, we used a contextual novelty-exploration paradigm to identify changes in gene expression in the dorsal hippocampus of both mice and rats. We found that changes in gene expression following contextual novelty varied between the two species, with 9 genes being upregulated in mice and 3 genes in rats. Comparison across species revealed that ArfGAP with a GTPase domain, an ankyrin repeat and PH domain 3 (Agap3) was the only gene being upregulated in both, suggesting a potentially conserved role forAgap3. AGAP3 is known to regulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor trafficking in the synapse, which suggests that increased transcription ofAgap3may be involved in maintaining functional plasticity. While we identified several genes affected by contextual novelty exploration, we were unable to fully reverse these changes using SCH 23390, a dopamine D1/D5receptor antagonist. Further research on the role of AGAP3 in novelty-induced memory consolidation could lead to better understanding of this process and guide future research.
Multiplexed volumetric CLEM enabled by antibody derivatives provides new insights into the cytology of the mouse cerebellar cortex
Authors: Lichtman Jeff , Han Xiaomeng , Lu Xiaotang , Li Peter , Wang Shuohong , Schalek Richard , Meirovitch Yaron , Lin Zudi , Adhinarta Jason , Berger Daniel , Wu Yuelong , Fang Tao , Meral Elif , Asraf Shadnan , Ploegh Hidde , Pfister Hanspeter , Wei Donglai , Jain Viren , Trimmer James
Published: July 2023

Mapping neuronal networks that underlie behavior has become a central focus in neuroscience. While serial section electron microscopy (ssEM) can reveal the fine structure of neuronal networks (connectomics), it does not provide the molecular information that helps identify cell types or their functional properties. Volumetric correlated light and electron microscopy (vCLEM) combines ssEM and volumetric fluorescence microscopy to incorporate molecular labeling into ssEM datasets. We developed an approach that uses small fluorescent single-chain variable fragment (scFv) immuno-probes to perform multiplexed detergent-free immuno-labeling and ssEM on the same samples. We generated eight such fluorescent scFvs that targeted useful markers for brain studies (green fluorescent protein, glial fibrillary acidic protein, calbindin, parvalbumin, voltage-gated potassium channel subfamily A member 2, vesicular glutamate transporter 1, postsynaptic density protein 95, and neuropeptide Y). To test the vCLEM approach, six different fluorescent probes were imaged in a sample of the cortex of a cerebellar lobule (Crus 1), using confocal microscopy with spectral unmixing, followed by ssEM imaging of the same sample. The results show excellent ultrastructure with superimposition of the multiple fluorescence channels. Using this approach we could document a poorly described cell type in the cerebellum, two types of mossy fiber terminals, and the subcellular localization of one type of ion channel. Because scFvs can be derived from existing monoclonal antibodies, hundreds of such probes can be generated to enable molecular overlays for connectomic studies.
Studying and improving reasoning in humans and machines
Authors: Palminteri Stefano , Yax Nicolas , Anllo Hernan
Published: July 2023

In the present study, we investigate and compare reasoning in large language models (LLM) and humans using a selection of cognitive psychology tools traditionally dedicated to the study of (bounded) rationality. To do so, we presented to human participants and an array of pretrained LLMs new variants of classical cognitive experiments, and cross-compared their performances. Our results showed that most of the included models presented reasoning errors akin to those frequently ascribed to error-prone, heuristic-based human reasoning. Notwithstanding this superficial similarity, an in-depth comparison between humans and LLMs indicated important differences with human-like reasoning, with models’ limitations disappearing almost entirely in more recent LLMs’ releases. Moreover, we show that while it is possible to devise strategies to induce better performance, humans and machines are not equally-responsive to the same prompting schemes. We conclude by discussing the epistemological implications and challenges of comparing human and machine behavior for both artificial intelligence and cognitive psychology.
Upregulation of BMP1 through ncRNAs correlates with adverse outcomes and immune infiltration of clear cell renal cell carcinoma
Authors: Gong Mancheng , Feng Shengxing , Zhou Dongsheng , Luo Jinquan , Lin Tianxin , Qiu Shaopeng , Yuan Runqiang , Dong Wenjing
Published: July 2023

Background: Renal cell carcinoma (RCC) accounts for approximately 2-3% of all adult malignancies, Clear cell renal cell carcinoma (ccRCC), which comprises 70-80% of all RCC cases, is the most common histological subtype.
Methods: ccRCC transcriptome data and clinical information were downloaded from the TCGA database. We used TCGA and GEPIA database to analyze the relative expression of BMP1 in various types of human cancer. In the meantime, GEPIA was used to perform survival analysis for BMP1 in various cancer types. Upstream binding miRNAs of BMP1 were obtained through several important target gene prediction tools. StarBase was used to predict candidate miRNA that could potentially bind to BMP1 and candidate lncRNAs that could potentially bind to hsa-miR-532-3p. We analyzed the association of the expression of BMP1 and immune cell infiltration level using TIMER website in ccRCC. Then, the relationship of BMP1 expression level and immune checkpoint expression level was also investigated.
Results: BMP1 was upregulated in GBM, HNSC, KIRC, KIRP and STAD, and downregulated in KICH and PRAD. Combined with OS and DFS, BMP1 can be used as a biomarker for poor prognosis in patients with KIRC. Through expression analysis, survival analysis and correlation analysis, LINC00685, SLC16A1-AS1, PVT1, VPS9D1-AS1, SNHG15 and CCDC18-AS1/hsa-miR-532-3p/BMP1 axis was established as the most potential upstream ncRNA-related pathway of BMP1 in ccRCC. Furthermore, we found that BMP1 level was significantly positively correlated with tumor immune cell infiltration, biomarkers of immune cells, and immune checkpoint expression.
Conclusion: Our results demonstrated that ncRNAs-mediated high expression of BMP1 associated with poor prognosis and tumor immune infiltration in ccRCC.
Embedding smart technologies in developing countries: digital agrotechnology in the sugarcane ethanol and bioenergy production system
Authors: Cezarino Luciana Oranges , de Oliveira Bruno Garcia , Liboni Lara Bartochi , Stocco Lucas Conde , de Araujo Geraldo Jose Ferraresi
Published: July 2023

As one of the most competitive industries in developing countries, agribusiness is seeking efforts to improve information systems and adopt digital technologies. In Brazil, the sugar energy industry is the country's oldest and most competitive business. The current technological transition is challenging to absorb the 4.0 paradigm in its production system, interconnecting the value chain through IoT, big data, artificial intelligence, and machine learning. Although there are opportunities with digitization, there are also many constraints in the industrial change process. This paper aims to explore the main changes in new technologies and processes towards industry 4.0 in the Brazilian sugarcane production system, identifying challenges and context restrictions. Using qualitative data from interviews with specialists – practitioners, and researchers - our findings show that this industry has many technological opportunities to digitize its production process. The industry’s main challenge is the low qualification for the workforce and difficulty in integrating new solutions into analogical production systems. Big companies invest in technology hubs while, at the same time, the internet is still scarce in rural areas, and small companies compete in less technological and sustainable supply chains. The findings support the decisions of the sugarcane industry in assessing the relevance of investing in Industry 4.0 projects. It demonstrates how digital transformation impacts process improvements, facilitating decision-making by using information networks interconnected to machine learning and automation.
Patching based Deep Learning approach for Retinal blood vessels segmentation
Authors: Garg Udit , Verma Prem Kumari , Singh Nagendra Pratap
Published: July 2023

Human Eyes are one of the important organs of the humanbody.They are also very prone to diseases such as cataracts, AgeRelated Macular Degeneration, Diabetic Retinopathy, Glaucoma, etc.Therefore, it becomes important to develop methods that can helpin the diagnosis and treatment of these diseases before it is toolate. In this paper, a time-efficient and accurate deep learningbased bio-medical image segmentation approach is presented whichcan lay the foundation for further development in this area.The u-net deep learning model used in the proposed approach, was specially developed to deal with medical images. The proposed approachhas been split into three notable phases: data pre-processing, training U-net deep learning model, and data post-processing. The U-netmodel is fed this data and trained until satisfactory results. Duringpost-processing, corresponding predicted images are merged to obtain toprediction for the original images. The final step includes the removalof padding so that the original dimensions of images are maintained After a long period of experimentation, quantitative performance metrics have been respectively calculated as 0.963, 0.992,0.910 for the DRIVE data set and 0.958,0.993,0.888 for theSTARE data set respectively. Values of Loss have been 0.106,and 0.106 for the DRIVE and STARE data sets respectively.
Peli1, regulated by m 6 A modification, suppresses atherosclerosis progression by inhibiting YB-1-mediated NLRP3 inflammasome activation
Authors: Liu Qiang , Yan Lu , Wu Tao , Wu Qinghua , Ke Ben , Shen Wen
Published: July 2023

Background The activation of NLRP3 inflammasome in macrophages is a risking factor accelerating atherosclerosis (AS) progression. Here, the function of Peli1 in regulating NLRP3 inflammasome activation during AS progression were investigated. MethodsApoE−/−mice were subjected to high fat diet to construct AS modelin vivo. HE, Oil red O and Sirius red staining were adopted to analyze histopathological changes and lipid accumulation. Raw264.7 cells stimulated by ox-LDL were used as AS cellular model. Pro-inflammatory cytokines secretion was assessed using ELISA. Total m6A level was examined by m6A dot blot assay, and Peli1 m6A level was assessed using MeRIP assay. The interactions between METTL3, YTHDC2, Peli1, YB-1 and NLRP3 were analyzed by ChIP, dual-luciferase reporter gene, CoIP, RIP and/or RNA pull down assays. Results YB-1 knockdown could inhibit AS progressionin vivo, and YB-1 silencing repressed ox-LDL-mediated lipid accumulation and inflammation in macrophages by inactivating NLRP3 inflammasome. E3 ubiquitination ligase Peli1 mediated ubiquitination degradation of YB-1 during AS progression. Moreover, it was found that YTHDC2 recognized METTL3-mediated Peli1 m6A modification and mediated Peli1 mRNA degradation. Rescue studies revealed that YB-1 upregulation abrogated Peli1 upregulation’s repression on AS progression bothin vitroandin vivo. Conclusion Peli1, regulated by m6A modification, inhibited YB-1-mediated NLRP3 inflammasome activation in macrophages by promoting YB-1 ubiquitination to suppress AS progression.
Elevated serum α-hydroxybutyrate dehydrogenase is an independent risk factor for survival outcomes in UTUC patients after radical nephroureterectomy
Authors: Ye Jianjun , Chen Zeyu , Wang Xingyuan , Zhang Chichen , Han Ping , Wei Qiang , Bao Yige
Published: July 2023

Background
To determine the prognostic value of α-hydroxybutyrate dehydrogenase (α-HBDH) on survival outcomes in upper tract urothelial carcinoma (UTUC) patients after radical nephroureterectomy (RNU).
Methods
Data from 544 UTUC patients who underwent RNU at West China Hospital from May 2003 to June 2019 were retrospectively acquired and analysed. Overall survival (OS), cancer-specific survival (CSS) and metastasis free survival (MFS) were the endpoints of interest. The cut-off value of α-HBDH was calculated by receiver operating characteristic. Kaplan-Meier curves were used to estimate patients’ survival and Cox proportional hazard model was used for risk assessment.
Results
Overall, 407 and 137 patients were divided into the α-HBDH-low group and α-HBDH -high group at the cutoff value of 161 U/L. Patients in the α-HBDH-high group showed significantly worse OS (p = 0.003), CSS (p = 0.025) and MFS (p = 0.031) than those in the α-HBDH-low group. However, serum α-HBDH level was not an independent predictor for OS, CSS or MFS in the multivariate Cox regression (all p > 0.05). The subsequent subgroup analysis about the pathological tumor stage suggested that higher serum α-HBDH value was significantly associated with better OS and CSS in localized UTUC patients (T ≤ 2) (HR 2.127, 95%CI 1.313–3.445; HR 1.846, 95%CI 1.030–3.308), but not in locally advanced UTUC patients (T > 2) (all p > 0.05).
Conclusion
The preoperative value of α-HBDH is an independent risk factor for survival outcomes in localized UTUC patients who underwent RNU.
Expansion of Thermoelectric Effect
Authors: Song Dongil
Published: July 2023

The thermoelectric effect of two metals was discovered by T. J. Seebeck, a German physicist. This research extends the thermoelectric effect of Seebeck's two metals. In this research, the thermoelectric effect of 16 materials, including soil, was tested. As a result of the test, electromotive force was generated when there was a temperature difference in all of them. Due to this electromotive force, current flows. This current creates a magnetic field (framing's left-hand rule). As no material has infinite electric resistance, an electromotive force is expected to be generated under a temperature difference in all materials. In conclusion, the thermoelectric effect generates an electromotive force. This electromotive force causes an electric current to flow, thereby generating a magnetic field. This magnetic field creates the Earth's magnetic field, Triboelectricity, Sunspots, Lightning, Earth's rotation, and the Kinetic Energy of Celestial Bodies. And it creates an ionosphere that reflects radio waves.
Mykhailo Verkhatskyi: Materials for a Biography
Authors: Lobko Nataliia
Published: July 2023

The article is about the outstanding Ukrainian director, theater expert, patriarch of Ukrainian theater pedagogy, laboratory director, secretary of the director's staff of «Berezіl» Les Kurbas, professor of the Kyiv Theater Institute Mykhailo Polijektovych Verkhatskyi. He is also known as a student and employee of Kurbas, the author of reports on directing and acting, articles and memoirs about Les Kurbas.
Based on the correspondence between his student V.S. Vasylko and the wife of L. Kurbas, it was established that it was thanks to the careful notes of Mykhailo Polievktovich that the priceless «Director's Diary» of L. Kurbas has been preserved to this day. At one time, he also copied a lot of Kurbas texts, as well as saved part of the manuscript materials from Kharkiv that were related to Kurbas, at the first opportunity he disassembled them, prepared them for printing, transferred them to the museum and thereby preserved them for future generations.
It is also a great merit of M. Verkhatskyi to develop the theoretical legacy of L. Kurbas and pass it on to the next theater generations. It turned out that he was among those students of Kurbas who sought to tell the truth about one of the prominent figures of the shot revival. For this, he was forced to leave Ukraine for sixteen years, escaping from persecution. In 1936, M. Verkhatskyi left for Uzbekistan. But even in distant Uzbekistan, he does not forget the lessons of Kurbas. In Tashkent, Mykhailo Polievktovich becomes the founder of the theater institute, its first director, starting the scientific history of the Uzbek theater and training theater experts, actors and directors.
In 1952, M. Verkhatskyi returned to Ukraine and began teaching at the Kyiv State Institute of Theater Arts (now the Kyiv National University of Theater, Film and Television named after I. K. Karpenko-Kary). The teacher worked at the acting department and in the period 1958–1963 he headed it and also taught directing. Namely this pedagogical period of his work researchers consider to be the most fruitful and mature.
It is noted that after returning to Kyiv, he tried to restore the honest name of his teacher – Les Kurbas. The pedigree of M. Verkhatskyi was investigated and it was established that his ancestors lived in Krolevets and the Andriyivka village of Hadyatsky district of Poltava province (now Sumy region).
Readiness Towards Artificial Intelligence Among Undergraduate Medical Students in Malaysia
Authors:   Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia, Xuan Pang Yi , Fahumida Mohamed Ismath Fathima ,   Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia, Al Nazir Hussain Muhammad Imran ,   Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia, Jayathilake Nethmi Thathsarani ,   Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia, Khobragade Sujata ,   Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia, Soe Htoo Htoo Kyaw ,   Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia, Moe Soe ,   Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia, Htay Mila Nu Nu ,   Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia
Published: July 2023

Artificial intelligence (AI) technology is growing at a fast pace and permeates many aspects of people’s daily lives. Medical students’ inclination towards AI in the medical field increases the probability of successful AI adoption and its value in the medical field. This study was conducted to evaluate medical AI readiness among undergraduate medical students. A cross-sectional study was conducted from March 2022 to April 2022 in a private medical institution in Malaysia. A non-probability purposive sampling method was used to enroll students and a questionnaire was distributed online via Google Forms. The questionnaire, captioned “Medical Artificial Intelligence Readiness Scale for Medical Students (MAIRS-MS)”, was used for data collection. The analysis included frequency tables, percentages, standard deviation, unpaired t-test, and analysis of variance (ANOVA) test. Out of 105 participants, 67.62% scored 53 to 83, followed by 24.76%, who scored 84 to 114, and 7.62%, who scored 22 to 52 on the medical AI readiness scale. The mean of the total score of medical AI readiness obtained was 75.04. There were significant correlations between age and study year with the ability, vision, and ethics domains of medical AI readiness. A significant association was observed between previous training with all four domains of medical AI readiness. Policymakers and the educational sector should set up more AI training centers to provide and introduce basic courses on AI. More AI courses should be provided to younger populations to engage in AI digital information earlier, thus enabling them to acquire more confidence in interacting with AI technology in the future.
Building Factors for the Trustful Relationship Among Medical Teachers and Students
Authors:   Department of Medical Education, University College of Medicine and Dentistry, Lahore, Pakistan, Mukhtar Khadijah , Ahmed Khan Rehan ,   Department of Medical Education, Riphah International University, Islamabad, Pakistan, Yasmeen Rahila ,   Department of Medical Education, Riphah International University, Islamabad, Pakistan, Mahboob Usman ,   Department of Medical Education, Khyber Medical University, Peshawar, Pakistan, Mukhtar Mahnoor ,   Department of Dentistry, University College of Medicine and Dentistry, Lahore, Pakistan
Published: July 2023

Our study aimed to explore the factors affecting the trustful relationship between teachers and students in a medical school, which is a subject that has attracted very little attention in literature. This study, conducted at the University College of Medicine and Dentistry in Pakistan, identified ways to increase the trustful relationship between teachers and students. Through a qualitative research design utilising an exploratory study method, one-to-one interviews were carried out with 10 medical students and 10 medical teachers. Data were recorded and transcribed verbatim, and codes and themes were applied using ATLAS.ti. Students revealed that a trustful relationship can be improved by enhancing teachers’ professionalism, accessibility, mentorship, empathy, and dedication, whereas students should possess emotional intelligence and conformist, fairness, affiliative, and achiever qualities to build trust with teachers. This study found that by working on these qualities, a trustful relationship can be improved between teachers and students.
Exploring the Hurdles in Integrating Artificial Intelligence in Medical Education: A Talk with ChatGPT
Authors:   Preclinical Department, Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, Malaysia, Vignesh Ramachandran , Pradeep Palanisamy ,   Preclinical Department, Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, Malaysia, Ravindran Jaganathan ,   Preclinical Department, Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, Malaysia
Published: July 2023

The integration of artificial intelligence (AI) in the medical field is rapidly increasing, and its importance is recognised as it can analyse medical information and improve patient outcomes. The Chat Generative Pre-trained Transformer (ChatGPT) by OpenAI is a language model that can respond to prompts in a human-like manner and has the potential to transform medical education. In this conversation, the authors engage with ChatGPT to discuss the challenges associated with the application of AI in medical education. ChatGPT acknowledges the limitations of AI in medical education and the importance of students demonstrating their understanding during assessments. It also discusses the need for academic policies to ensure the responsible and ethical use of AI in medical education.
Demand Side Perception on Success Factors for Implementing Public Road Construction Projects
Authors:   Department of Accounting and Finance, Makerere University Business School, Kampala, UGANDA, Mwelu Noah , Watundu Susan ,   Department of Management Science, Makerere University Business School, Kampala, UGANDA, Moya Musa ,   Faculty of Computing and Informatics, Makerere University Business School, Kampala, UGANDA
Published: July 2023

Cost and schedule overruns, as well as substandard works, are common factors that fail organisations’ objectives within the construction industry. Particularly, these factors affect public road construction projects and cost taxpayers. Researchers continue scanning the environment to establish why construction projects are ever behind schedule and over budget with substandard works and contract variations to identify significant factors for successful project implementation. This study expands the debate by looking at demand side perception in establishing success factors for implementing public road construction projects motivated by governments’ high expenditure on construction projects without meeting objectives. A cross-sectional research design with a structured self-administered questionnaire was used to obtain views from three public entities representing the demand side. Results were analysed following partial least square structural modelling (PLS-SEM) in Smart-PLS3. The research design enabled statistical tests to be conducted on validity, reliability, normality, multicollinearity, correlations and regression. The PLS algorithm and bootstrapping resampling approach were employed to determine the relationship between variables by estimating path coefficients and significance. Path coefficients helped to determine strength, direction and significance, and examine the variance of dependent variables explained by combined independent variables. Results revealed that the professionalism of the staff, compliance with the public procurement regulatory framework, monitoring activities and contractors’ resistance to non-compliance are significant success factors in enhancing public road implementation. Hence, adopting these factors would be a game changer in implementing complex road construction projects. In addition, complex construction projects in a dynamic construction industry require continuous scanning to establish more factors and cope with industry dynamics.
Capital Budgeting Implementation by Public Sector Construction Firms in Tanzania’s Housebuilding Industry: An Exploratory Study
Authors:   Department of Building Economics, School of Architecture, Construction Economics and Management, Ardhi University, Dar es Salaam, TANZANIA, Sospeter Nyamagere Gladys , Awuzie Bankole Osita ,   School of Construction Economics and Management, University of Witwatersrand, Johannesburg, SOUTH AFRICA
Published: July 2023

This exploratory study investigates the implementation of capital budgeting practices (CBP) by selected public sector construction firms (PSCF) in Tanzania. This investigation seeks to assess the extent, to which such practices are used for effective investment decision-making, with a particular focus on the country’s housebuilding sector. A case study research design was adopted to collect data from five Tanzanian PSCF, serving as cases through a mix of questionnaires, interviews and document reviews. The emergent data was analysed using thematic analysis. An appreciable level of CBP implementation was observed in all the cases. The internal rate of return (IRR), net present value (NPV) and payback period (PBP) capital budgeting techniques (CBT) were observed to be mostly used by these PSCF, while sensitivity analysis was widely deployed for risk mitigation. The influence of top management in decision- making, political influence and lack of advanced software were some of the implementation challenges identified. The findings contribute to the elucidation of CBP implementation praxis in the public sector organisation context in developing countries, as it relates to the housebuilding industry in Tanzania’s unexplored context. The study proves to be a valuable resource for public sector entities in developing countries intent for facilitating effective investment decision-making about infrastructure procurement and it contributes to improving knowledge of CBP implementation, consideration of risk mitigation factors and post-project implementation audits by public sector firms.
A STUDY TO ASSESS THE KNOWLEDGE AND ATTITUDE OF POSTNATAL MOTHER REGARDING POSTNATAL DIET IN A VIEW OF DEVELOPING BOOKLET AT SELECTED COMMUNITY AREA
Authors: Tomar Sonam , Chand Shivani , Basera Manoj , a Sonam , b Shabnam , c Anshika , d Kajol
Published: July 2023

Introduction: the postnatal period is the period that begins immediately after childbirth. The postnatal period is a critical, yet often neglected period in a new parents life. According to world health organization (WHO), most maternal and newborn death occurs in this period, therefore, proper parent and newborn management and care are vital. Postnatal diet is the diet that a womens body need to recover from exhaustion of physiological state and child bearing. Objectives : To assess the knowledge and attitude of postnatal mothers regarding postnatal diet in selected area of community in a form of developing booklet and to find the significant association between the knowledge and attitude of postnatal mothers regarding postnatal diet . Method: The research approach for the present study is quantitative approach aimed to assess the knowledge and attitude of postnatal mothers regarding postnatal diet. The research design used for the study is descriptive design. The study was conducted in selected area of community at Sahaspur, Dehradun. The sample sizes for this study were 100 postnatal mothers. Convenient sampling techniques are used for this study. Self â€“structured questionnaire method are used for data collection. Result: The present study finding revealed that the majority of the 66% postnatal mothers have good knowledge, 23% average knowledge and 11% has poor knowledge. There was no statistically significant association between the level of knowledge with their demographic variables. The present study finding revealed that the level of attitude by likert scale that was done by yes and no response of postnatal mothers mostly yes was the response and positive attitude has been seen. Conclusion: The conclusion of the study majority of (66%) postnatal mothers has good knowledge regarding postnatal diet. Then we have assessed the level of attitude by likert scale that was done by yes and no response of postnatal mothers mostly yes was the response and positive attitude has been seen. The need of the study is to improve knowledge and attitude of postnatal mothers with the help of booklet.
REVOLUTIONIZING CLUSTER FINANCING: A NEW DAWN IN ECONOMIC STRATEGY
Authors:   Professor/Lecturer Tashkent State University of Economics Islam Karimov Street 49 100066 Tashkent, Uzbekistan., Dilorom Maxamadjanovna Mutalova
Published: July 2023

Clusters are important drivers of economic growth, innovation, and competitiveness. However, financing remains a major challenge for many clusters, particularly those in emerging economies or in industries that are not well-established. This research article explores ways to improve the financing of clusters, including government policies, private sector investments, and public-private partnerships. The article also highlights some successful examples of cluster financing from around the world.
TIME DEPENDENT EVALUATION OF EFFICACY ON INHIBITION OF BACTERIAL AND FUNGAL GROWTH OF THREE DISINFECTANTS BY IMMERSION AND SPRAYING METHOD ON POLYVINYL SILOXANE IMPRESSION MATERIAL - AN IN-VITRO STUDY
Authors: Mondal Saptarshi , Das Samiran , Ghosh Soumitra , Majumdar Sayan , Barui Ananya
Published: July 2023

Aim:To determine the efficacy of three disinfectants-2% Glutaraldehyde,0.2% Peracetic acid,70%Isopropyl alcohol with time(3 minutes and 7 minutes) on Staphylococcus Sp. and Candida Sp. on polyvinyl siloxane impression material. Settings and Design:This was an in vitro comparative study. Materials and Methods:A standard inoculum of 0.5 McFarlandwas applied on the prepared polyvinyl siloxane disc surface.Discs were disinfected by immersion and spraying method for 3 minutes and 7 minutes.After that discs were collected in nutrient broth,vortexed and a small volume of the broth was centrifuged.It was thentransferred to test tube containing neutralizing agents of the corresponding disinfectants.0.1 ml from the test tube was transferred to culture plate and incubated to study thesurvivality of Staphylococcus Sp. and Candida Sp. Statistical Analysis Used:One way ANOVAtest was performed to check the mean reduction of microorganism in each group after disinfection by immersion and spraying.Inter group comparison of disinfection efficacy within certain time(3 minutes or 7 minutes) span was done by Tukeys post hoc test. Results:Percentage(%) of mean reduction of staphylococcus and candidas growth obtained from this studywere 99.99% by immersion and spraying method within 3 minutes and 7 minutes. Significance:Both immersion and spraying methods had similar reduction efficacy(99.99%) when compared with control.
KNOWLEDGE, ATTITUDE AND PRACTICESAMONGPRIMARY CARE WORKERS ON INFECTION, PREVENTION AND CONTROL AMIDST THE COVID-19 PANDEMIC
Authors: Nathanniel S. Ferrer RN , MPH Andrew , Garin Ed.D Zosima
Published: July 2023

Insufficient awareness of infectious diseases among primary care workers results in delayed detection of new cases, the spread of infection, and inadequate infection control methods. Therefore, primary care workers must be well-informed about infection, prevention, and control procedures and guidelines in order to wage an effective war against COVID-19. This study seeks to examine the knowledge, attitudes, and behaviors (KAP) of healthcare workers regarding infection, prevention, and control in the context of COVID-19 in several primary care facilities in Baguio City. Between March and April 2022, a descriptive, correlational online questionnaire-based study was conducted. Using ANOVA and Pearson r, differences in the degree of KAP among diverse subjects were evaluated. A total of 119 HCWs from primary facilities responded to the survey. Overall, respondents had general level of IPC knowledge (AWM of 3.69), had laid-back attitudes, and consistently used 9/10 indicators. Poor KAP performance was associated with inadequate training. The female employees were more knowledgeable and had a more positive attitude, but the male employees were more likely to practice appropriately on a regular basis. Notably, participants from the nursing profession exhibited a less positive attitude than those from other medical professions. Nevertheless, they had to be the best at employing appropriate techniques. The inadequacy of KAP among Primary care workers, coupled with the persistence of the pandemic, highlights the need for sustained COVID-19-specific infection control training, which should be incorporated into the annual operational planning.
A REVIEW AND CURRENT SITUATION OF PCOS WITH INFERTILITY
Authors:   Department of Pharmacy Practice, M.M. Collage of Pharmacy, Maharishi Markandeshwar (Deemed To Be University) Mullana- Ambala (Haryana) India -133207., Rahman Mahbubur , Sharma Kritika ,   Department of Pharmacy Practice, M.M. Collage of Pharmacy, Maharishi Markandeshwar (Deemed To Be University) Mullana- Ambala (Haryana) India -133207., Sethi Harshita ,   Department of Pharmacy Practice, M.M. Collage of Pharmacy, Maharishi Markandeshwar (Deemed To Be University) Mullana- Ambala (Haryana) India -133207., Thakur Neha ,   Department of Pharmacy Practice, M.M. Collage of Pharmacy, Maharishi Markandeshwar (Deemed To Be University) Mullana- Ambala (Haryana) India -133207.
Published: July 2023

Polycystic ovary syndrome (PCOS) is a condition in which the ovaries produce an abnormal amount of androgens. PCOS causes an imbalance of androgen hormones and causes many of the symptoms of the disorder. It affects about 8-10% of all women of reproductive age and 22% in India. If lifestyle changes are not successful in controlling the symptoms of PCOS, then women may be advised to consider weight loss surgery.In some cases, the weight loss surgery may be combined with hormonal therapy.This treatment aims to achieve even greater weight loss, which may lead to the reduction of excessive facial and body hair. Too much testosterone can also interfere with the development of the follicles (the sacs in the ovaries where eggs develop) and prevents normal ovulation (the release of a mature egg). Hypothyroidism (low thyroid function) is common in women with PCOS. Excess androgens can be induced by insulin resistance and hyperinsulinemia, as they cause a reduction in sex hormone binding globulin levels, which lead to a subsequent increase in free androgens and unfavourable metabolic profiles. The ovarian PCOS morphological traits of enlarged, multi-cystic ovaries and theca interstitial hyperplasia are reported in women who are subjected to high levels of androgens as a result of endogenous adrenal androgen hyper secretion in congenital adrenal hyperplasia treatment in female-to-male transsexuals. Even if an egg is released, the uterus lining or the endometrial may not be ready for pregnancy Symptoms of PCOS The following symptoms will help you understand PCOS occurrence: Irregularity in menstrual cycles or lack of cycles Excessive body or facial hair is seen in teens and females in their 20s The condition worsens over the years with an increase in hair growth It is due to the surplus testosterone and androstenedione that results in high male hormone production in females in their blood. Reproductive age, approx 10% of women are affected by this syndrome, with common symptoms including weight gain, irregular periods, acne, an increase in body hair, and infertility due to ovulation failure.
A STUDY ON EFFICIENCY OF MERGER AS A TOOL FOR FINANCIAL DISTRESS IN INDIAN PUBLIC SECTOR BANKS
Authors:   Professor, Department of Accountancy and Law, Faculty of Commerce, Dayalbagh Educational Institute (Deemed University), Dayalbagh, Agra, India., Peppal Shivani , Sharma Nidhi ,   Professor, Department of Accountancy and Law, Faculty of Commerce, Dayalbagh Educational Institute (Deemed University), Dayalbagh, Agra, India.
Published: July 2023

Merger has become an efficient tool to cop up with financial difficulties in all the industries. In past few years Indian banking Industry is going through so many merger and the recent merger which has been taken place is of bank of Baroda, Dena Bank and Vijaya Bank. This study has been conducted to know the effectiveness of Merger to cope up which financial distress in these selected banks in terms of their Non-Performing Assets. The study has two objectives one is to understand the concept of Non-Performing Assets of Indian banks and second is to examine the impact of merger on financial performance of selected Indian public sector banks. For the analysis for factors i.e. Gross NPA, Net NPA, Percentage of Gross NPA, Percentage of Net NPA and Net Profit or Loss have been considered for the period of ten financial years which was divided into before and after merger period as the merger of selected banks was took place in 2019. The results of the study show that there is a significance difference between the before merger performance and after merger performance of the selected banks.
PURPOSE OF NURSES IN INFECTION CONTROL AND PREVENTION IN MEDICAL MANAGEMENT. A NEW APPRAISAL
Authors:   Primary Health Care Center, Bader Aljanob Hospital, Najran, Kingdom Of Saudi Arabia., Hussein Ali Al Omar Abdullah , Mosfoh Saud Al Salem Samhah ,   Primary Health Care Center, Bader Aljanob Hospital, Najran, Kingdom Of Saudi Arabia., Huseein Ali Al Omar Sultan ,   Primary Health Care Center, Bader Aljanob Hospital, Najran, Kingdom Of Saudi Arabia., Mufarrih Mohammed Alyami Salem ,   Primary Health CareCenter, Bader Aljanob Hospital, Najran, Kingdom Of Saudi Arabia., Masfoh Saud Al Salem Fatmah ,   Al-Ghadeer Primary Health Care Center, Riyadh, Kingdom Of Saudi Arabia.
Published: July 2023

Infection Control activity works in tandem with all healthcare disciplines to provide quality patient care through education and practical application of the principles of microbiology, epidemiology, and infection prevention and control.Infection prevention and control (IPC) is a practical, evidence-based approach that prevents patients and health workers from being harmed by avoidable infection as a result of antimicrobial resistance. No one should catch an infection while receiving health care, yet, these infections can spread through outbreaks and many regular care practices, affecting hundreds of millions of people across the world every year. Infection prevention and control is one of the first topics introduced in nursing programs, yet its main tenets are often lost or forgotten. Objectives: The main objective of these guidelines is to prevent the health care workers and the environment from the transmission of infections. The specific objectives of these guidelines are to provide directions and information in relation to facilities, equipment, and procedures necessary to implement standard and additional (transmission-based) precautions for control of infections Cleaning, disinfecting and reprocessing of reusable equipment, Waste management, Protection of health care workers from transmissible infections, Prevention of HAI in patients, Infection control practices in special situations.
Adjunctive antihypertensive therapy of primary glaucoma with a fixed combination drug of 1% brinzolamide and 0.5% timolol: efficacy and safety
Authors: Petrov S. Yu. , Kalinina O. M. , Yakubova L. V. , Kosakyan S. M. , Vasilenkova L. V. , Filippova O. M. , Zhuravleva A. N. , Markelova O. I.
Published: July 2023

Purpose: a comparative study of the efficacy and safety of the combination drug Brinzopt Plus and the original drug Azarga used as adjunctive therapy in patients with primary open-angle glaucoma (POAG) previously treated with latanoprost.

Material and methods. 30 patients (42 eyes) with advanced and far advanced POAG were randomly divided into 2 groups of equal size. The patients of the main group (21 eyes) received Brinzopt Plus, those of the control group had the original drug Azarga, one instillation 2 times a day. The target points were intraocular pressure (IOP), visual acuity, perimetric indices (MD, PSD), mean retinal nerve fiber layer thickness, minimal neuroretinal rim width, retinal nerve fiber layer thickness in the macula, ganglion cell layer thickness in the macula, inner plexiform layer thickness, as well as the number of adverse events. The observation period was 12 weeks. IOP was measured at 4 and 12 weeks.

Results. After 2 weeks, both groups showed a statistically significant decrease in IOP, which remained stable after 4 and 12 weeks. The average decrease in IOP in Brinzopt Plus recipients was 25% and revealed no statistically significant differences with the original drug at any control point. A positive dynamic of visual acuity, static perimetry and optical coherence tomography values, which showed no significant intergroup differences, was recorded. Among the adverse events, manifestations of mild local discomfort were recorded in 4 out of 15 patients of the main group and in 3 out of 15 patients of the control group. No serious or systemic adverse events were noted.

Conclusion. Brinzopt Plus has an efficacy comparable to the original drug and a favorable safety profile.
Prevalence of myopia among teenager students of Orenburg city schools
Authors: Aprelev A. E. , Cherkasov S. V. , Serebryakova P. E. , Aprelev A. A. , Cherkasova P. S.
Published: July 2023

Purpose: to study the prevalence and manifestation features of myopia in students of educational schools in the city of Orenburg.

Material and methods. 710 schoolchildren of Orenburg schools, aged 11 to 18, were examined.

Results. Myopia was found to be the most common pathology of the eye, diagnosed in 33.5 % of schoolchildren. The most frequent was low myopia claiming 65.4 % of myopic cases, followed by moderate myopia (28.5 %) and high myopia (6.1 %). The highest occurrence of myopia was revealed in 11th and 8th grade students (respectively, 55.8 and 40,0 cases per 100 examined subjects). It was found out that the share of more severe myopia stages (moderate and high) in increasing in older age groups 5th-grade to 11th-grade students. We also showed that myopia prevalence is connected with head and spine injuries in the case history.

Conclusion. Educational facilities need to introduce an effective system of myopia prevention and means of progression reduction.
Strategically oriented correction of mixed astigmatism in children
Authors: Tarutta E. P.
Published: July 2023

Purpose: evaluation of the remote functional and refractive results of mixed astigmatism correction in preschool children with “plus” cylinders in the framework of a long-time longitudinal study.

Material and methods. 38 children (75 eyes) aged 1.5–7 years (averagely 4.2 years) with mixed astigmatism of 0.75 to 4.25 D (averagely 1.85 D) were followed up for 6-15 (averagely 7.3) years. At the first examination, all children were prescribed to permanently wear (+) cylinders of 0.5 D to 3.5 D. Over the follow-up period, (+) Cyl could be weakened in 24 eyes (32 %) due to a decrease in astigmatism, while (-) Sph had to be added in 24 eyes (32 %). due to an increased refraction. In cases when the full correction using a “plus” cylinder left an excessively large myopic defocus, the power of the “plus” cylinder was reduced so as not to add a “minus” sphere, and a second pair of glasses was prescribed for near vision, which offered a full correction of astigmatism with the “plus” cylinder.

Results. After 6–15 years, astigmatism changed in 85 % of the examined eyes: it increased in 7 eyes (averagely, by 0.3 D) and decreased in 53 (averagely, by 0.9 D, p < 0.05; with the maximum reduction of 2.75 D). The spheric-equivalent refraction changed in 51 % of eyes, with an average increase of 0.53 D. The maximum increase of refraction was 2.8 D, while the maximum drop was 1.4 D. Visual acuity of the children who wore the prescribed eyeglasses permanently, showed after two years an increase, average achieving the level of 0.84, which by the end of the follow-up period achieved 0.99.

Conclusion. The proposed plan of mixed astigmatism correction, which preserves residual weak myopic defocus, fully ensured both tactical and strategic effects: prevention and elimination of amblyopia, and containment of refraction myopization.