bluuebunny/crossref_metadata_2025 huggingface dataset:
Aberrant Cholesterol Metabolic Genes Regulation in a Negative Feedback Loop Induced by an Alphacoronavirus
Authors: Liu Hao-Yu , Gu Haotian , Qu Huan , Bao Wenbin , Li Yanhua , Cai Demin
Published: March 2022

Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus that causes acute inflammation and severe diarrhea in newborn piglets with a high mortality rate. Given that cholesterol is required for coronavirus infection in vitro, the role of endogenous cholesterol metabolism in regulating coronavirus infection and the mechanism behind it ought to be elucidated. In this study, we found that the levels of cholesterol and bile acids were both elevated in the livers of PEDV-infected piglets compared to those of the control group. Consistently, in the livers of PEDV-infected piglets, the expression of key genes involved in cholesterol metabolism was significantly increased. Transcriptomic analysis indicated that the cholesterol homeostasis pathway was among the most enriched pathways in the livers of PEDV-infected piglets. Unexpectedly, the expression of key genes in the cholesterol metabolic pathway was downregulated at the messenger RNA (mRNA) level, but upregulated at the protein level. While the primary transcriptional factors (TFs) of cholesterol metabolism, including SREBP2 and FXR, were upregulated at both mRNA and protein levels in response to PEDV infection. Further Chromatin Immunoprecipitation Quantitative Real-time PCR (ChIP-qPCR) analysis demonstrated that the binding of these TFs to the locus of key genes in the cholesterol metabolic pathway was remarkably inhibited by PEDV infection. It was also observed that the occupancies of histone H3K27ac and H3K4me1, at the locus of the cholesterol metabolic genes HMGCR and HMGCS1, in the livers of PEDV-infected piglets, were suppressed. Together, the PEDV triggers an aberrant regulation of cholesterol metabolic genes via epigenetic inhibition of SREBP2/FXR-mediated transcription, which provides a novel antiviral target against PEDV and other coronaviruses.
Verification and Validation of a Four-Gene Panel as a Prognostic Indicator in Triple Negative Breast Cancer
Authors: Pariyar Mamta , Thorne Rick F. , Scott Rodney J. , Avery-Kiejda Kelly A.
Published: March 2022

Triple negative breast cancer (TNBC) is a highly aggressive subtype with a high rate of metastasis, early distant recurrence and resistance to therapy leading to worse survival than other breast cancer subtypes. There are no well-established biomarkers that can determine women who will do better and those who are likely to have poorer outcomes with TNBC, nor are there targeted therapies. Thus, the identification of prognostic and/or predictive biomarkers will enable tailored therapies based on their likelihood of disease outcomes and may prevent over- and under-diagnosis. Previous studies from our laboratory have identified four genes (ANP32E, DSC2, ANKRD30A and IL6ST/gp130) that are specific to TNBC and were associated with lymph node metastasis (LNmets), the earliest indicator of tumor progression via distal spread. This study aimed to validate these findings using absolute quantitation by digital droplet PCR (ddPCR) and to determine relationships with clinicopathological features and survival. Our analysis confirmed all four genes displayed significant expression differences between TNBC cases and non-TNBC cases. Moreover, low IL6ST expression was significantly associated with grade 3 disease, hormone receptor negativity and earlier age at diagnosis; low ANKRD30A expression was associated with tumor size; and high ANP32E expression was significantly associated with grade and the number of positive lymph nodes. Individually, three of the four genes were associated with relapse-free survival in TNBC and in combination, all four genes were significantly associated with TNBC survival, but not in hormone receptor-positive cases. Collectively our results suggest that the four genes may have utility in TNBC prognostication.
Physiological, Proteomic Analysis, and Calcium-Related Gene Expression Reveal Taxus wallichiana var. mairei Adaptability to Acid Rain Stress Under Various Calcium Levels
Authors: Hu Wen-Jun , Liu Ting-Wu , Zhu Chun-Quan , Wu Qian , Chen Lin , Lu Hong-Ling , Jiang Chen-Kai , Wei Jia , Shen Guo-Xin , Zheng Hai-Lei
Published: March 2022

As one of the serious environmental problems worldwide, acid rain (AR) has always caused continuous damage to the forestry ecosystem. Studies have shown that AR can leach calcium ions from plants and soil. Calcium (Ca) is also a crucial regulator of the plant stress response, whereas there are few reports on how Ca regulates the response of AR-resistant woody plants to AR stress. In this study, by setting different exogenous Ca levels, we study the physiological and molecular mechanism of Ca in regulating the Taxus wallichiana var. mairei response to AR stress. Our results showed that low Ca level leads to photosynthesis, and antioxidant defense system decreases in T. wallichiana var. mairei leaves; however, these negative effects could be reversed at high Ca level. In addition, proteomic analyses identified 44 differentially expressed proteins in different Ca level treatments of T. wallichiana var. mairei under AR stress. These proteins were classified into seven groups, which include metabolic process, photosynthesis and energy pathway, cell rescue and defense, transcription and translation, protein modification and degradation, signal transduction, etc. Furthermore, the study found that low Ca level leads to an obvious increase of Ca-related gene expression under AR stress in T. wallichiana var. mairei using qRT-PCR analyses and however can be reversed at high Ca level. These findings would enrich and extend the Ca signaling pathways of AR stress in AR-resistant woody plants and are expected to have important theoretical and practical significance in revealing the mechanism of woody plants tolerating AR stress and protecting forestry ecosystem in soil environment under different Ca levels.
The Development of Intergroup Cooperation: Children Show Impartial Fairness and Biased Care
Authors: Corbit John , MacDougall Hayley , Hartlin Stef , Moore Chris
Published: March 2022

One of the most remarkable features of human societies is our ability to cooperate with each other. However, the benefits of cooperation are not extended to everyone. Indeed, another hallmark of human societies is a division between us and them. Favoritism toward members of our group can result in a loss of empathy and greater tolerance of harm toward those outside our group. The current study sought to investigate how in-group bias impacts the developmental emergence of concerns for fairness and care. We investigated the impact of in-group bias on decisions related to care and fairness in children (N = 95; ages 4–9). Participants made decisions about how to allocate resources between themselves and a peer who was either an in-group or out-group member. In decisions related to care, participants were given two trial types on which they could decide whether to give or throw away a positive or negative resource. In decisions related to fairness participants and peer partners each received one candy and participants decided whether to allocate or throw away an extra candy. If the extra candy was distributed it would place either the participant or their recipient at a relative advantage, whereas if the extra candy was thrown away the distribution would be equal. We found that on fairness trials children’s tendency to allocate resources was similar toward in-group and out-group recipients. Furthermore, children’s tendency to allocate resources changed with age such that younger participants were more likely to allocate extra candies to themselves, whereas older participants were more likely to allocate extra candies to their recipient. On trials related to care we did observe evidence of in-group bias. While distribution of positive resources was greater than negative resources for both in-group and out-group recipients, participants distributed negative resources to out-group recipients more often compared to in-group recipients, a tendency that was heightened for young boys. This pattern of results suggests that fairness and care develop along distinct pathways with independent motivational supports.
Pre-conditioning Strategies for Mesenchymal Stromal/Stem Cells in Inflammatory Conditions of Livestock Species
Authors: Uberti Benjamin , Plaza Anita , Henríquez Claudio
Published: March 2022

Mesenchymal stem/stromal cells (MSCs) therapy has been a cornerstone of regenerative medicine in humans and animals since their identification in 1968. MSCs can interact and modulate the activity of practically all cellular components of the immune response, either through cell-cell contact or paracrine secretion of soluble mediators, which makes them an attractive alternative to conventional therapies for the treatment of chronic inflammatory and immune-mediated diseases. Many of the mechanisms described as necessary for MSCs to modulate the immune/inflammatory response appear to be dependent on the animal species and source. Although there is evidence demonstrating an in vitro immunomodulatory effect of MSCs, there are disparate results between the beneficial effect of MSCs in preclinical models and their actual use in clinical diseases. This discordance might be due to cells' limited survival or impaired function in the inflammatory environment after transplantation. This limited efficacy may be due to several factors, including the small amount of MSCs inoculated, MSC administration late in the course of the disease, low MSC survival rates in vivo, cryopreservation and thawing effects, and impaired MSC potency/biological activity. Multiple physical and chemical pre-conditioning strategies can enhance the survival rate and potency of MSCs; this paper focuses on hypoxic conditions, with inflammatory cytokines, or with different pattern recognition receptor ligands. These different pre-conditioning strategies can modify MSCs metabolism, gene expression, proliferation, and survivability after transplantation.
Perspective about Cellulose-Based Pressure and Strain Sensors for Human Motion Detection
Authors: Basarir Fevzihan , Kaschuk Joice Jaqueline , Vapaavuori Jaana
Published: March 2022

High-performance wearable sensors, especially resistive pressure and strain sensors, have shown to be promising approaches for the next generation of health monitoring. Besides being skin-friendly and biocompatible, the required features for such types of sensors are lightweight, flexible, and stretchable. Cellulose-based materials in their different forms, such as air-porous materials and hydrogels, can have advantageous properties to these sensors. For example, cellulosic sensors can present superior mechanical properties which lead to improved sensor performance. Here, recent advances in cellulose-based pressure and strain sensors for human motion detection are reviewed. The methodologies and materials for obtaining such devices and the highlights of pressure and strain sensor features are also described. Finally, the feasibility and the prospects of the field are discussed.
Finite-Element Analysis of Adjacent Concrete Box Girders Transversely Post-Tensioned at the Top Flanges Only
Authors: Labib Shady N. , El-Salakawy Ehab F.
Published: March 2022

A three-dimensional non-linear finite-element model (FEM) was constructed using a commercial software (ATENA-Studio) to investigate the transverse load distribution behavior of adjacent precast prestressed concrete box-girder bridges. An innovative connection between box girders was used, where transverse post-tensioning was applied at the top flanges only eliminating the need for intermediate transverse diaphragms. The FEM was validated in terms of deflections, strains, cracking and ultimate loads against experimental results previously reported by the authors. The validated FEM was then used to perform a parametric study investigating the influence of adding concrete topping, load location, and bridge width on the transverse load distribution behavior of the newly developed connection. The results of the FEM demonstrated the efficiency of concrete topping in limiting mid-span deflections up to 25%. Additionally, the maximum live load moment distribution factors (LLMDFs) for different load locations and bridge widths were evaluated.
Novel Application of a Surgeon-Operated Clysis Delivery System in Burn Surgery
Authors: Morzycki Alexander , Kwan Peter O. , Tredget Edward E. , Wong Joshua N.
Published: March 2022

Insufflation of epinephrine-containing solutions (clysis) has shown to decrease blood loss in burn surgery. Current delivery methods are associated with significant cost and may predispose burn patients to hypothermia. This was a proof-of-concept study to evaluate a novel surgeon-operated clysis delivery system. Our initial experience with a novel fluid management system is presented. Temperature, pressure, and volume of clysis was recorded. Patient and burn factors were evaluated and complications collected. Finally, a cost-effectiveness analysis was conducted. Thirty-seven consecutive cases comprising 22 adult patients (15/22, 68% male), with a mean age of 49 years (+/−19) were reviewed. The mean % total body surface area of all patients was 39 (+/−21.7). The mean temperature, pressure, and volume of administered clysis was 32.2 degrees Celsius (+/−4.4), 265.04 mmHg (+/−56.17), and 5805.8 mL (+/−4844.4), respectively. The mean dose of epinephrine administered was 14.5 mg (+/−12.1). The mean temperature variability was 1.1 °C (+/−1.2). The total mean of packed red blood cells (PRBC) transfused was 507.6 mL (+/−624.4). There were no recorded complications. We identified a cost savings of CAD 20,766 over the cases examined, compared to our conventional clysis delivery technique. This novel technique provides rapid and safe infiltration of warmed clysis in burn surgery. We were able to maintain intra-operative euthermia. In addition, this technique may be transfusion-sparing. The introduction of this method of clysis administration was associated with significant cost-savings. Future randomized study is necessary.
Law and Policy Review on Green Hydrogen Potential in ECOWAS Countries
Authors: Ballo Abdoulaye , Valentin Koffi Kouakou , Korgo Bruno , Ogunjobi Kehinde Olufunso , Agbo Solomon Nwabueze , Kone Daouda , Savadogo Moumini
Published: March 2022

This paper aims to review existing energy-sector and hydrogen-energy-related legal, policy, and strategy documents in the ECOWAS region. To achieve this aim, current renewable-energy-related laws, acts of parliament, executive orders, presidential decrees, administrative orders, and memoranda were analyzed. The study shows that ECOWAS countries have strived to design consistent legal instruments regarding renewable energy in developing comprehensive legislation and bylaws to consolidate it and to encourage investments in renewable energy. Despite all these countries having a legislative basis for regulating renewable energy, there are still weaknesses that revolve around the law and policy regarding its possible application in green hydrogen production and use. The central conclusion of this review paper is that ECOWAS member states presently have no official hydrogen policies nor bylaws in place. The hydrogen rise presents a challenge and opportunity for members to play an important role in the fast-growing global hydrogen market. Therefore, these countries need to reform their regulatory frameworks and align their policies by introducing green hydrogen production in order to accomplish their green economy transition for the future and to boost the continent’s sustainable development.
Potential Translational Thioflavin T Methodology as a Complement of Cell-Based Assays and after Drug Exposition
Authors: Correia Ana Salomé , Duarte Diana , Miranda-Gonçalves Vera , Vale Nuno
Published: March 2022

Protein aggregation is a common characteristic of several human diseases such as Alzheimer’s disease. Recent evidence has indicated that the aggregation of peptides such as p53 is also marked in cancer cells. The aim of this study was to correlate Thioflavin T (ThT) data with different cellular viability assays (Neutral Red and MTT) in SH-SY5Y neuroblastoma cells and HT-29 colon cancer cells treated with doxorubicin, a classical antineoplastic agent. We also studied the effects of the well-known peptide Aβ42 on the aggregation process in these cells. Our data suggest that both cancer cell lines are responsive to doxorubicin and formed aggregates, highlighting a relationship between ThT and cellular viability methodologies. We observed that lower values of cell viability corresponded with pronounced aggregation. Thus, these results indicated that the ThT methodology used in cells may complement the cell viability assays. In addition, this methodology may be of interest to evaluate the role of protein aggregation in other cancer cells.
Acclimation Effects of Natural Daily Temperature Variation on Longevity, Fecundity, and Thermal Tolerance of the Diamondback Moth (Plutella xylostella)
Authors: Xing Kun , Zhao Fei
Published: March 2022

Daily temperature amplitudes (DTAs) significantly affect the ecological and physiological traits of insects. Most studies in this field are based on laboratory experiments, while there is limited research on the effects of changes in DTA on insect phenotypic plasticity under natural conditions. Therefore, we studied the acclimation effects of DTA on the longevity, total fecundity, early fecundity, and the thermal tolerance of adult diamondback moths (Plutella xylostella L.) under naturally occurring environmental conditions. As DTAs increased, male longevity and total fecundity decreased, and early fecundity increased. An increase in DTA was significantly associated with the increased heat coma temperature (CTmax) of both males and females, but had no significant effect on their cold coma temperature (CTmin). Our findings highlight the effects of DTA on the acclimation response of P. xylostella and emphasize the importance of considering DTA in predicting models for assessing insect populations and the effects of climate change.
Otorhinolaryngological Advancements in Phoniatrics
Authors: Tseng Wen-Hsuan , Huang Tzu-Yen
Published: March 2022

The production of voice is a powerful tool not only for communication, but also for artistic performances [...]
Simulation of Soil Organic Carbon Content Based on Laboratory Spectrum in the Three-Rivers Source Region of China
Authors: Zhou Wei , Li Haoran , Wen Shiya , Xie Lijuan , Wang Ting , Tian Yongzhong , Yu Wenping
Published: March 2022

Soil organic carbon (SOC) changes affect the land carbon cycle and are also closely related to climate change. Visible-near infrared spectroscopy (Vis-NIRS) has proven to be an effective tool in predicting soil properties. Spectral transformations are necessary to reduce noise and ensemble learning methods can improve the estimation accuracy of SOC. Yet, it is still unclear which is the optimal ensemble learning method exploiting the results of spectral transformations to accurately simulate SOC content changes in the Three-Rivers Source Region of China. In this study, 272 soil samples were collected and used to build the Vis-NIRS simulation models for SOC content. The ensemble learning was conducted by the building of stack models. Sixteen combinations were produced by eight spectral transformations (S-G, LR, MSC, CR, FD, LRFD, MSCFD and CRFD) and two machine learning models of RF and XGBoost. Then, the prediction results of these 16 combinations were used to build the first-step stack models (Stack1, Stack2, Stack3). The next-step stack models (Stack4, Stack5, Stack6) were then made after the input variables were optimized based on the threshold of the feature importance of the first-step stack models (importance > 0.05). The results in this study showed that the stack models method obtained higher accuracy than the single model and transformations method. Among the six stack models, Stack 6 (5 selected combinations + XGBoost) showed the best simulation performance (RMSE = 7.3511, R2 = 0.8963, and RPD = 3.0139, RPIQ = 3.339), and obtained higher accuracy than Stack3 (16 combinations + XGBoost). Overall, our results suggested that the ensemble learning of spectral transformations and simulation models can improve the estimation accuracy of the SOC content. This study can provide useful suggestions for the high-precision estimation of SOC in the alpine ecosystem.
The Effects of a Virtual Reality Tourism Experience on Tourist’s Cultural Dissemination Behavior
Authors: Zeng Yanfang , Liu Lihua , Xu Rui
Published: March 2022

Virtual reality technology has been widely applied in the tourism industry, but the literature examining the relationship between the virtual tourism experience and cultural dissemination behavior is limited. This present study examines how a virtual reality tourism experience could stimulate tourists’ cultural dissemination behavior intention. It does so by developing a moderated mediation model to explore how virtual reality tourism uses digital technology to improve tourists’ experiential value, enhances their pride, and then affects their cultural dissemination behavior intentions. Results derived from a sample of 359 respondents show that VR experiential value can stimulate tourists’ cultural dissemination behavior and that the link between VR experiential value and tourists’ cultural dissemination behavior is mediated by pride. Furthermore, the cultural value of individual collectivism moderates the relationship between VR experiential value and pride. This study extends the theoretical understanding of virtual reality tourism from the emotional perspective and also has practical implications for VR design and destination marketing.
Apie santuokos apeigų „valstybinimą“ sovietų Lietuvoje
Authors: Lankauskas Gediminas
Published: March 2022

On the ‘Statising’ of Marriage Rites in Soviet Lithuania

The article explores marriage rituals in Soviet Lithuania using ethnographic and historical materials. These socially significant life-cycle rites were strategically mobilised by the authoritarian state for ideological propaganda, and for the consolidation of its power and legitimacy. In an effort to make its dominance more pervasive, the Party purposely ‘statised’ marriage rituals, by rendering them secular, investing them with ideologically neutralised ‘folk culture’, and by reconfiguring them aesthetically. ‘Statising’ is discussed
as a polyvalent process, which aimed at appropriating and controlling the space-time, or chronotopes, of wedding participants. Their resistive responses directed against the hegemony of the Soviet state are also examined.

Key words: marriage rites, Soviet Lithuania, the state, time and space, pluralism
of meaning.
Migracija į Lietuvą studijų tikslais ir tarptautinių studentų identiteto raiška integracijos ir atskirties perspektyvoje
Authors: Kazlauskaitė Ilona
Published: March 2022

Migration to Lithuania for Studies, and the Expression of the I dentity of International Student from the Perspective of Integration and Exclusion

Migration for studies is growing rapidly around the world, and is becoming
a characteristic trait of contemporary higher education. The challenges faced
by international students, including language and cultural differences,
legal and social restrictions, the uncertainty of belonging, vulnerability, and
the sense of otherness, are significant factors when describing notions of
international student identity transformation. The results of the research
conducted reveal that international students appreciate the changes in their
identity during their studies in Lithuania, as an opportunity to create a new
hybrid identity of an international student, and networks based on their
values and experience in the new environment.

Key words: migration for studies, international students, identity, integration,
and exclusion.
Lauminėjimas muziejuje: lietuvių liaudies žaidimo užrištomis akimis gyvoji rekonstrukcija
Authors: Rakaitytė Vaida
Published: March 2022

Blind Man’s Buff at the Museum: A Live Reconstruction of the Traditional Lithuanian Folk Game Lauminėjimas

This article analyses the live reconstruction of Blind Man’s Buff as the version of traditional Lithuanian folk game Lauminėjimas at the Open-Air Museum of Lithuania. The article examines the reconstruction as a performative process, when the game creates a situation during which moving in a large and complex exhibit, a dwelling surrounded by small exhibits, the participants unexpectedly encounter authentic exhibits as an ethnographic entity. Participants acquire individual experiences of getting to know the
dark period of the Christmas season in many ways in the context of prior and acquired knowledge in the museum through symbols encoded by the museum staff.

Key words: live reconstruction, performativity, authenticity, the Open-Air Museum
of Lithuania.
Derecho Comparado de la Justicia Transicional entre México y Colombia
Authors: Cuicas Chamu Mitzi Gabriela
Published: March 2022

La investigación fue un estudio sobre los avances jurídicos de Justicia Transicional entre México y Colombia como un aporte para la Construcción de la Paz y contribuir a la resolución del conflicto social violento en México. Por lo que el objetivo de la investigación fue analizar el marco jurídico de cada país y visualizar su evolución jurídica, con una metodología de nivel propositivo y un enfoque mixto, donde la parte cuantitativa corresponde a las bases de datos sobre la violencia de México y con relación al enfoque cualitativo se abordan en entrevistas semiabiertas a profundidad a actores de la Justicia Especial para la Paz de Colombia. De los resultados se desprende la importancia de establecer procesos de Justicia Transicional en México y la diminuta legislación aplicable que tiene en la actualidad. Se logró establecer que el origen de la justicia transicional en Colombia fue a causa de un conflicto interno armado por paramilitares y en el caso mexicano se observó que existe una perspectiva de justificar la delincuencia organizada y el narcotráfico como delitos.
EXCESS MORTALITY DURING THE COVID-19 PANDEMIC: RUSSIAN REGIONS AGAINST THE BACKDROP OF THE COUNTRY
Authors:   Novosibirsk State Pedagogical University, Novosibirsk, Russia Novosibirsk State Medical University, Novosibirsk, Russia, Goroshko N.V. , Patsala S.V. ,   Novosibirsk State Pedagogical University, Novosibirsk, Russia
Published: March 2022

The object of the study is the excess mortality of the population in the context of the COVID-19 pandemic. on a regional scale. The problem of excess mortality in the context of the COVID-19 pandemic is widely analyzed in domestic studies. At the same time, coverage of the problem at the regional level in scientific publications is not enough today: the issue of the causes of excess mortality requires study, taking into account the individual "contribution" of mortality rates for the main classes of diseases to the regional aspect. The aim of the research is to identify the scale of excess mortality in Russia in the regional context in the context of the COVID-19 pandemic, taking into account the “contribution” of the main types of diseases. General logical and analytical methods, methods of statistical analysis and empirical research, and a cartographic method were used as a methodological basis of the study. The information base of the paper was publications in periodicals and the Internet, demographic statistics data from Rosstat, statistical data from the Coronavirus-Control.ru website (Coronavirus Control), Yandex. Coronavirus: statistics. The complexity of the analysis of regional statistical information lies in its subjectivity for a number of indicators, which include the deaths cases from COVID-19, mortality, the proportion of deaths from coronavirus disease in the structure of total mortality. Among the main reasons that determine subjectivism, it is possible to single out the method of calculation and the efficiency of providing information by the regions. It should be noted that the results obtained in the study are preliminary due to the limited statistical base used. Excess mortality is one of the important resulting indicators, leveling the difficulties and shortcomings of the operational registration of the deaths associated with the COVID-19 pandemic and its indirect consequences. Excess mortality in 2020 (calculated using the 5 yearly moving average method) was recorded in 82 out of 85 Russian regions. The result of the work: in the course of the study, indicators of excess mortality were calculated in the regions of the Russian Federation both in general and for the main types of diseases. To visualize the obtained regional data, they were mapped. Based on the regression analysis performed, the paper determined a close relationship between regional indicators of excess mortality from all causes of death, from the main types of death causes, and those who died from COVID-19.
BEST CORPORATE PRACTICES AS THE BASIS FOR REFORMING THE EXISTING REGULATIONS IN THE SPHERE OF OCCUPATIONAL HEALTH AND SAFETY
Authors:   All-Russian Scientific Research Institute of Labor, Moscow, Russia, Komin A.I.
Published: March 2022

Today, attitudes towards occupational health and safety are undergoing a major transformation: engineering knowledge, industrial hygiene knowledge, knowledge of behavioral science and management science are beginning to come together to create an integrated safety system. In accordance with Decree of the Government of the Russian Federation No. 833-r dated April 26, 2019, the Ministry of Labor and Social Protection of Russia is implementing a set of measures to encourage employers and employees to improve working conditions and preserve the health of employees, as well as motivate citizens to lead a healthy lifestyle, including improving mechanisms for preventing industrial injuries and occupational morbidity; encouraging employers and employees to improve working conditions and preserve the health of employees; implementing monitoring activities. According to paragraph 11 of this decree, the collection, analysis and dissemination of the best corporate and regional practices are carried out. With regards to this, the aim of this study is to identify and analyze existing practices to improve occupational health and safety in organizations. The relevance and scientific novelty of the research lie in the fact that according to the presented samples of the best corporate practices, it is possible to form recommendations for making changes to the existing regulatory legal acts. A comprehensive, statistical, mathematical and comparative analysis of the data obtained during the survey of organizations was used as a methodological basis of the study. The results and conclusions of the paper are to identify the most optimal measures and recommendations for introduction into the current regulatory legal acts.
Monitorização da variação secular dos parâmetros climatológicos em Coimbra: o caso da precipitação para análise de riscos hidrológicos
Authors: Domingues Joana R. , Pais Maria Alexandra , Ribeiro Paulo , Pereira Alcides , Mantas Vasco
Published: March 2022

Este estudo consiste numa análise secular das séries de valores diários de precipitação do Observatório Geofísico e Astronómico da Universidade de Coimbra (OGAUC), durante o período de 1880 a 1990. A valorização dessas séries foi possível pela transferência para formato digital das tabelas de dados dos Anuários do Observatório Meteorológico e Magnético, mais tarde convertido em Instituto Geofísico da UC. Pretende-se pesquisar a relação entre a precipitação medida na estação meteorológica da Av. Dr. Dias da Silva e as cheias registadas em Coimbra. Durante a maior parte do período analisado o rio Mondego apresentou um regime natural, sendo que apenas durante os últimos 10 anos da série de dados estudada o regime de caudal passou a estar regularizado. Foi utilizada a Análise em Componentes Principais para identificação dos principais modos de variabilidade da precipitação, e comparada a evolução temporal desses modos com séries de índices meteorológicos usualmente tidas como proxies do clima observado em Portugal. Os resultados obtidos estão de acordo com estudos anteriores, mas sugerem também novas linhas de pesquisa.
Tendências de evolução temporal dos caudais médios diários em bacias de montanha do NE de Portugal
Authors: Okada Vinícius Kenzo , de Figueiredo Tomás , Fonseca Felícia , dos Santos Maurício Morerira
Published: March 2022

As zonas de montanha são de fulcral importância para o regime hidrológico das grandes bacias, designadamente quanto ao risco a que estão expostas as suas zonas baixas. A resposta hidrológica das bacias de montanha é muito variada em consequência das condições de relevo que determinam variabilidade espacial acentuada na precipitação. O presente trabalho tem por objetivo avaliar tendências de evolução temporal nas últimas décadas na resposta hidrológica de bacias de montanha dos rios Tuela, Sabor e Maçãs, situadas ao longo de um gradiente climático no NE de Portugal. Por meio de dados hidrométricos registados durante 42 anos hidrológicos analisaram-se os escoamentos fluviais e os respetivos hidrogramas a fim de separar as componentes do escoamento (base e direto) a essa escala temporal. Utilizou-se análise de regressão linear aplicada às séries cronológicas para avaliar as tendências de variação no caudal médio e suas componentes. O incremento na aridez ao longo do gradiente climático estudado corresponde redução da proporção de escoamento de base no total, acentuado ao longo da série e significando tendência para o aumento do escoamento direto. Portanto, evidenciam-se acréscimos na severidade dos riscos hidrológicos (seca e cheia) nas últimas décadas, mais importantes nas bacias de menor precipitação.
Inundações urbanas na Amazónia setentrional, Boa Vista-RR-Brasil
Authors: Araújo Júnior Antônio Carlos Ribeiro
Published: March 2022

A despeito de desastres ocorridos na Amazônia Setentrional Brasileira relativos a inundações, faz-se referência a cidade de Boa Vista, capital do estado de Roraima. Esta, em 5 de junho de 2011 entrou em Estado de calamidade pública devido às fortes chuvas na região. A cidade de Boa Vista-RR ficou isolada, pois, as rodovias federais (principal modal de transporte) BR-174 e BR-401 permaneceram interditadas para tráfego por mais de 1 mês. Desta forma, tem-se como objetivo entender, discutir e vislumbrar o passado, o presente e futuro, respectiva e concomitantemente, de Boa Vista a fim de apontar caminhos possíveis e palpáveis no processo de planejamento e gestão da cidade, a qual está em crescimento horizontal e acaba por desencadear impactos sociais (em razão da ocupação de áreas de risco, principalmente a alagamento), bem como físicos (em razão da ocupação de Área de Preservação Permanente).
Contribuição da educação na resolução do risco de inundação: estudo de caso através da observação de imagens
Authors: Talaia Mário , Talaia Pedro
Published: March 2022

São apresentados fundamentos teóricos que permitem a interpretação do risco de inundações. São usadas imagens de diferentes locais para mostrar as consequências do risco de enchente face ao leito normal de um rio ou linha de água. A interpretação da física envolvida na interpretação dos fenómenos físicos parece ser uma valiosa contribuição para se tomarem estratégias de prevenção de eventos futuros.
Estudo das inundações do rio Mondego a jusante da confluência do rio Ceira até à ponte Açude
Authors: Fragoso Teresa , Bravo João , Correia António , Santos Luís Araújo
Published: March 2022

As inundações do Rio Mondego na cidade de Coimbra, nomeadamente na região do Baixo Mondego (planícies dos arrozais de Montemor-o-Velho) têm vindo a ocorrer mais recorrentemente. No entanto, não existe uma metodologia científica de apoio à decisão, que possibilite um aviso atempado às populações. Com vista ao desenvolvimento de uma metodologia de previsão de cheias, considera-se uma secção de estudo do Rio Mondego, com 6 km localizada entre a confluência do Rio Ceira com o Rio Mondego e a Ponte do Açude. Utilizando o Hec-Ras, um software de modelação dinâmica, modelaram-se situações de escoamento variado unidimensional e bidimensional, para vários cenários, incluindo o transporte de sedimentos e a análise da qualidade da água entre outros cálculos hidráulicos. Os resultados obtidos potenciam o planeamento de operações de Proteção Civil, envolvendo o aviso às populações, em situações de precipitações elevadas na bacia hidrográfica do Rio Mondego.
CARACTERIZACIÓN QUÍMICA DE TRES GENOTIPOS DE CANOLA (Brassica napus L.) PRODUCIDOS CON Y SIN APLICACIÓN DE BRASINOESTEROIDES
Authors: Sosa-Montes Eliseo , Sosa-Montes Esther , Pro-Martínez Arturo , Irizar-Garza Martha B. G. , Mendoza-Pedroza Sergio I. , Sánchez-Olguín Joyce , Alejos-de la Fuente José I.
Published: March 2022

El objetivo de este estudio fue caracterizar químicamente la respuesta de tres genotipos de canola (Monty, Hyola-401 e IMC-204) a la aplicación de brasinoesteroides en la planta. Mediante un diseño completamente al azar y un arreglo factorial se establecieron seis tratamientos (tres genotipos con y sin aplicación de brasinoesteroides). En muestras de semilla se determinaron las variables: extracto etéreo (EE), proteína cruda (PC), proteína cruda soluble (PCS), proteína cruda insoluble en detergente neutro (PCIDN) y proteína cruda insoluble en detergente ácido (PCIDA); todas expresadas como porcentaje en base seca. Los genotipos Hyola-401 y Monty mostraron los contenidos más altos de PCS (20.2 y 18.5 %, respectivamente) y PC (24.5 y 24.6 %, respectivamente). El genotipo Hyola-401 presentó los contenidos más bajos de PCIDA (4.4 %), de PCIDN (7.1 %) y de EE (42.0 %). La PC promedio de los tres genotipos aumentó con la aplicación de brasinoesteroides (22.7 a 24.8 %), principalmente en el genotipo Hyola-401 (21.7 a 26.3 %). En conclusión, el genotipo Hyola-401, que mostró valores bajos de EE, PCIDN y PCIDA, aumentó su contenido de proteínas mediante la aplicación de brasinoesteroides.
EFECTO DE SUPLEMENTOS FERMENTADOS CON POLLINAZA SOBRE EL CONSUMO Y DEGRADACIÓN DEL PASTO CUBA CT-115
Authors: Ramos-Juárez Jesús A. , Martínez-Urbina Ernesto , Izquierdo-Reyes Francisco , Aranda-Ibañez Emilio M. , Vargas-Villamil Luis M. , Hernández-Sánchez David , Joaquín-Torres Bertín M.
Published: March 2022

Los pastos tropicales presentan digestibilidad baja, por lo que se deben buscar alternativas para mejorar la degradación de la materia seca y sus componentes. El objetivo del estudio fue evaluar el efecto de la suplementación a base de pollinaza, fermentada y sin fermentar, en el consumo y degradación ruminal de nutrientes del pasto Cuba CT-115 (Pennisetum purpureum). Se evaluaron cinco tratamientos: T1: pasto Cuba CT-115, T2: T1 + pollinaza sin fermentar, T3: T1 + pollinaza fermentada, T4: T1 + pollinaza + pulido de arroz fermentado y T5: T1 + pollinaza + pulido de arroz sin fermentar. Se utilizaron cinco toretes con fístula ruminal y un diseño cuadrado latino 5×5. Se determinó el índice de consumo de materia seca (ICMS), degradación in situ de la MS (DIMS), degradación efectiva ruminal de la MS (DERMS), MO (DERMO), PC (DERPC), FDN (DERFDN) y FDA (DERFDA), N-NH3 y pH ruminal. El ICMS fue de 2.5 % del PV en dietas suplementadas y 2.0 en el control (P < 0.01). La DIMS a 24 h de incubación ruminal fue 46.9 % en dietas suplementadas y 41.8 % en el control. La DERMS fue similar entre tratamientos (P > 0.05), mientras que la DERFDN y DERFDA tuvieron promedios de 35.2 % y 25.0 %, siendo 19.74 % y 33.2 % mayores en relación al pasto, respectivamente. La DERPC fue menor en dietas suplementadas (P < 0.01). El pH ruminal fue similar entre tratamientos (P > 0.05), con un valor promedio de 6.6. Las mayores concentraciones de N-NH3 (29.8 y 29.1 mg dL-1) ocurrieron a tres h después de la alimentación en T4 y T5, respectivamente. El uso de la pollinaza, con o sin fermentar en dietas de bovinos, puede ser una alternativa para mejorar la eficiencia de utilización del pasto Cuba CT-115.
CONTROL QUÍMICO DE Leptodictya plana (HEMIPTERA: TINGIDAE) Y DAÑO FOLIAR EN CULTIVARES DE Cenchrus purpureus
Authors: Felipe-Victoriano Moisés , Barrón-Bravo Oscar G. , Estrada-Drouaillet Benigno , Joaquín-Cancino Santiago , Vega-Chávez Jorge L. , Garay-Martínez Jonathan R.
Published: March 2022

Leptodictya plana Heidemann es una plaga emergente de Cenchrus purpureus en Altamira, Tamaulipas, México. En este estudio se evaluó la mortalidad de la chinche de encaje (L. plana) por el efecto de cuatro insecticidas a diferentes dosis: Alfacipermetrina + Imidacloprid (19:45, 39:90 y 54:135 ppm), Spinetoram (90, 120 y 150 ppm), Sulfoxaflor (225, 300 y 375 ppm) y Tiacloprid (200, 300 y 400 ppm), más el control (agua destilada más Tween 20 al 0.03 %). También se evaluó el daño foliar (%) causado por esta plaga en los cultivares de C. purpureus: Camerún, Caña Africana, Cuba CT115, Elefante, King Grass, Maralfalfa, Mott, OM-22, Taiwan y Uruguana. La mortalidad en chinches de encaje con la aplicación de Alfacipermetrina 8.45 % + Imidacloprid 19.72 % y Tiacloprid 40.40 % fue de 0.95 a 1.00 a partir de las 8 a 24 horas después de la aplicación. La mortalidad a dosis de 90 ppm (Spinetoram) y 225 ppm (Sulfoxaflor) fue de 0.76 y 0.73, respectivamente, a las ocho horas después de la aplicación, mientras que a las 24 horas fue > 0.99. El mayor daño foliar se observó en los cultivares Mott y Camerún (71 y 62 %, respectivamente); los cultivares Uruguana, King Grass y Elefante presentaron el menor daño (entre 21 y 28 %). Los insecticidas Alfacipermetrina + Imidacloprid y Tiacloprid causaron una mortalidad de 1.00, por lo que pueden ser empleados para el control de la chinche de encaje.
الأخطاء الشائعة في كتابة اللغة العربية للمادة الخط والإملاء وتحليلها لطالبات المدرسة التأهيلية بمعهد سلفية شافعية سوكرجو سيتوبندو جاوى الشرقية
Authors: Kholison Muhammad
Published: March 2022

تحليل الأخطاء (Error analysis) Error analysis is one of the applicable language disciplines that can be used to determine the level of language errors of a student when learning a foreign language, in this case is Arabic Language. تحليل الأخطاء '(Error analysis) is important to be carried out by teachers, such as teachers who teach the subject matter of al-Khath wa al-Imla', in order to determine students' abilities in writing Arabic, so that with Error analysis they can analyze student errors and then determine teaching materials and learning methods, what he will do. The results of this study are that the errors that occur in the Arabic writing of the students are divided into two, namely: 1) الأغلاط (errors) that fall into the Aghlath Error category (الغلاط), for example, writing the letters incorrectly because the sound is not clear, or students are less focused in hearing what the teacher says, 2) الأخطاء that fall into the Akhto mistakes  category are errors caused by students' missunderstanding of language rules, for example two words that should be separated, joined, words that should start with أل, don't use أل
The Influence of Regional Original Income (PAD) and Remaining Budget Financing (SiLPA) on Economic Growth with General Allocation Funds (Dau) as Moderating Variables in Regency/City Governments in North Sumatra Province in 2011-2015
Authors: Diastrina Dita
Published: March 2022

This study aims to identify and analyze whether revenue (PAD) and Surplus Financing Articles (SiLPA) effect on economic growth by the General Allocation Fund (DAU) as moderating variables. The study population was the District / City in the province of North Sumatra. The method of this thesis is a descriptive statistical analysis, classic assumption test, test hypotheses and residual test. Independent variables in this study is revenue (PAD) and Surplus Financing Articles (SiLPA), while the dependent variable is economic growth and moderating variable is the General Allocation Fund (DAU) with Total population of this research are 33 districts / cities using purposive sampling obtained 18 districts / cities as samples from 2013 to 2015. the type of data used is secondary data. The results of this study demonstrate that, in the original income (PAD) and Surplus Financing Articles (SiLPA) have a significant effect on economic growth at the Regency / City in the province of North Sumatra. In partial revenue (PAD) has a significant effect on economic growth, while Budget Financing Surplus (SiLPA) has no effect and no significant effect on economic growth in the Regency / City in the province of North Sumatra. General Allocation Fund (DAU) can moderate revenue (PAD) on economic growth, while the financing Budget Surplus, DAU can not moderate relations to economic growth. while Budget Financing Surplus (SiLPA) has no effect and no significant effect on economic growth in the Regency / City in the province of North Sumatra. General Allocation Fund (DAU) can moderate revenue (PAD) on economic growth, while the financing Budget Surplus, DAU can not moderate relations to economic growth. while Budget Financing Surplus (SiLPA) has no effect and no significant effect on economic growth in the Regency / City in the province of North Sumatra. General Allocation Fund (DAU) can moderate revenue (PAD) on economic growth, while the financing Budget Surplus, DAU can not moderate relations to economic growth.
Gender-oriented psychotherapy of anxiety disorders in internally displaced persons
Authors: Kraskovska T.Yu.
Published: March 2022

Anxiety disorders have significant gender features in clinical and psychopathological phenomenology and psychosocial maladaptation, in addition, significant differences in the mechanisms of anxiety disorders in men and women, determine the specifics of clinical, psychopathological and pathopsychological manifestations and determine the need for treatment and diagnostic approaches. A comprehensive examination of 150 patients with anxiety disorders, both sexes, aged 20-55 years was conducted. The main group consisted of 84 patients (43 women and 41 men) who participated in developed psychotherapeutic program, the control group – 66 patients (34 women and 32 men) who received standard regulated therapy in the hospital. According to the results of the study stable therapeutic effect was achieved by patients of the main group with personalized psychotherapeutic program (positive dynamics of anxiety symptoms, increased psychophysical activity) in 73.2% of men and 74.5% of women. In patients of the main group there was a significant decrease in anxiety and depression by the Hospital Anxiety and Depression Scale (71.7% of men and 69.6%), by the Hamilton Depression Rating Scale (72.7% of men and 75.7% of women); in patients of the control group, dynamics of scores by psychodiagnostic scales was insignificant. The data obtained during the study show that in the complex treatment of patients with anxiety disorders one of the crucial components of therapy is not only pharmacotherapy, but also psychotherapeutic interventions, which in turn depend on nosology and gender component.

Keywords: anxiety, psychotherapy, IDPs, migrants, gender features.
La mejora postsiembra de ciclo corto desde un mini motocultor ergonómico
Authors: Herrera-Andrade Miguel Aníbal
Published: March 2022

La investigación se planteó como propósito establecer el rendimiento de un mini motocultor ergonómico doble propósito que permita mejorar el proceso de postsiembra de ciclo corto en la sierra ecuatoriana. A partir de una investigación explicativa se buscó comprobar el rendimiento de esta herramienta, para ello, se utilizó como muestra 2 terrenos de una hectárea cada uno con el propósito de comparar la producción, costos, y rentabilidad. El rendimiento del mini motocultor es favorable en consideración a las horas de trabajo empleado por superficie de terreno, por cuanto realiza el trabajo equivalente a 30 personas por día en una hectárea, para lo cual, se necesita una inversión de 600$ por cada 30 días de trabajo en comparación a los 13500$ que se necesitan si no se emplea este dispositivo. Se concluye que se requiere que los agricultores en su contexto cultural establezcan siembra de ciclo corto sostenible y sustentable.