bluuebunny/crossref_metadata_2025 huggingface dataset:
Wrist Extensor Muscle Fatigue During a Dual Task With Two Muscular and Cognitive Load Levels in Younger and Older Adults
Authors: Wagenblast Florestan , Läubli Thomas , Seibt Robert , Rieger Monika A. , Steinhilber Benjamin
Published: December 2023

Objective

To examine the effect of concurrent physical and cognitive demands as well as age on indicators of muscle fatigue at the wrist.

Background

There are few studies examining risk indicators for musculoskeletal disorders associated with work-related physical and cognitive demands that often occur simultaneously in the workplace.

Methods

Twenty-four gender-balanced older and 24 gender-balanced younger (mean age 60 and 23 years) participants performed four 30 min dual tasks. Tasks differed by the muscular load level during force tracking: 5% and 10% of maximum voluntary contraction force (MVC) and concurrent cognitive demands on the working memory: easy and difficult. Muscle fatigue was assessed by MVC decline and changes in surface electromyography (increased root mean square: RMS, decreased median frequency: MF) at the extensor digitorum (ED) and extensor carpi ulnaris (EU).

Results

A decline in MVC was found in all participants when tracking was performed at 10% MVC (mean ± SD: 137.9 ± 49.2 – 123.0 ± 45.3 N). Irrespective of age, muscular, or cognitive load, RMS increased (ED 12.3 ± 6.5 – 14.1 ± 7.0% MVE, EU 15.4 ± 7.6 – 16.9 ± 8.6% MVE) and MF decreased (ED 85.4 ± 13.6 – 83.2 ± 12.8 Hz, EU 107.2 ± 17.1 – 104.3 ± 16.7 Hz) in both muscles. However, changes in MF of EU tended to be more pronounced in the older group at higher cognitive and lower muscular load, without reaching statistical significance.

Conclusion

Maximum voluntary contraction indicated no interaction between muscle fatigue, cognitive load, or age. However, the tendencies toward altered muscle activity due to an increase in cognitive load and older age suggest muscular adaptations while maintaining tracking performance during the onset of fatigue signs in the sEMG signal.

Application

If the tendencies in muscle activity are confirmed by further studies, ergonomic assessments in industrial workplaces should consider cognitive load and age when describing the risk of musculoskeletal disorders.
Hope, resilience and subjective happiness among general population of Paraguay in the post COVID-19 pandemic
Authors: Torales Julio , Barrios Iván , Melgarejo Osvaldo , Ruiz Díaz Noelia , O’Higgins Marcelo , Navarro Rodrigo , Amarilla Diego , Almirón-Santacruz José , González-Urbieta Israel , Caycho-Rodríguez Tomás , Castaldelli-Maia João Mauricio , Ventriglio Antonio
Published: December 2023

Background:

Positive mental health includes not only the absence of mental disorders but also the presence of subjective well-being, good coping strategies for life stress, and strategies for adapting to community life. It is well known that the COVID-19 pandemic has challenged mental health in general population worldwide. However, research has not measured protective factors for mental health in the general population after the declared end of pandemic by the World Health Organization.

Methods:

This observational, cross-sectional study surveyed 591 Paraguayan participants aged ⩾18 years, who were recruited through an online survey. Demographic characteristics, socioeconomic status were collected as well as mental health and validated tools for hope, resilience, subjective happiness were administered.

Results:

Of the participants, 81.6% were women, 54% were married or in a relationship and 90.7% reported an university education. The main source of stress was economic issues (30.3%). A total of 22.7% had been previously diagnosed with a mental disorder, 22.2% had consulted a mental health professional and 10.8% had consumed prescription drugs. 42.6% reported flourishing, 36.2% reported moderate and 21.2% reported languishing mental health.

Conclusions:

This large survey has shown that most of participants reported a flourishing mental health with high ratings at hope, resilience, and subjective happiness scales. Also, the main sources of stress were economic issues, not consequently related to the pandemic. This may add evidences to the international debate on the long term effects of the global pandemic and probably suggests that recovery processes have been collectively adopted in Paraguay.
Turkey’s Foreign Policy Toward Africa: Three Levels of Analysis
Authors: Sıradağ Abdurrahim
Published: December 2023

Turkey has been actively engaged in African politics since the Justice and Development Party (AK Party) government announced the year 2005 as the Year of Africa. The strategic importance of Africa for Turkey has significantly increased during the AK Party governments. The number of Turkey–Africa studies done both in Turkey and in the West has increased since 2010, but most of these studies dealt with Turkish foreign policy toward Africa from a narrow perspective. This study highlights that there are complicated, hidden, and interrelated factors and dynamics driving Turkey–Africa relations. In particular, the systematic factors are the most overlooked dynamics in the studies carried out. This study endeavors to explore these complicated dynamics in a systematic and holistic approach by using the three levels of analysis. The main research question in the study is, “What are the individual, state, and systemic factors shaping Turkish foreign policy toward Africa?” In this research, primary and secondary sources and the “process-tracing research method” were used.
A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2
Authors: Tsutsumi-Arai C. , Arai Y. , Tran A. , Salinas M. , Nakai Y. , Orikasa S. , Ono W. , Ono N.
Published: December 2023

The mandibular condylar cartilage (MCC) is an essential component of the temporomandibular joint, which orchestrates the vertical growth of the mandibular ramus through endochondral ossification with distinctive modes of cell differentiation. Parathyroid hormone–related protein (PTHrP) is a master regulator of chondrogenesis; in the long bone epiphyseal growth plate, PTHrP expressed by resting zone chondrocytes promotes chondrocyte proliferation in the adjacent layer. However, how PTHrP regulates chondrogenesis in the MCC remains largely unclear. In this study, we used a Pthrp-mCherry knock-in reporter strain to map the localization of PTHrP+ cells in the MCC and define the function of PTHrP in the growing mandibular condyle. In the postnatal MCC of Pthrp mCherry/+ mice, PTHrP-mCherry was specifically expressed by cells in the superficial layer immediately adjacent to RUNX2-expressing cells in the polymorphic layer. PTHrP ligands diffused across the polymorphic and chondrocyte layers where its cognate receptor PTH1R was abundantly expressed. We further analyzed the mandibular condyle of Pthrp mCherry/mCherry mice lacking functional PTHrP protein (PTHrP-KO). At embryonic day (E) 18.5, the condylar process and MCC were significantly truncated in the PTHrP-KO mandible, which was associated with a significant reduction in cell proliferation across the polymorphic layer and a loss of SOX9+ cells in the chondrocyte layers. The PTHrP-KO MCC showed a transient increase in the number of Col10a1+ hypertrophic chondrocytes at E15.5, followed by a significant loss of these cells at E18.5, indicating that superficial layer–derived PTHrP prevents premature chondrocyte exhaustion in the MCC. The expression of Runx2, but not Sp7, was significantly reduced in the polymorphic layer of the PTHrP-KO MCC. Therefore, PTHrP released from cells in the superficial layer directly acts on cells in the polymorphic layer to promote proliferation of chondrocyte precursor cells and prevent their premature differentiation by maintaining Runx2 expression, revealing a unique PTHrP gradient-directed mechanism that regulates MCC chondrogenesis.
Teaching Summative Assessment: A Curriculum Analysis of Pre-Service Language Teacher Education in Sweden and Finland
Authors: Yildirim Ali , Oscarson Anne Dragemark , Hilden Raili , Fröjdendahl Birgitta
Published: December 2023

The purpose of this study is to investigate the curricular manifestation of summative assessment literacy in language pre-service teacher education at three universities in Sweden and Finland through multiple case studies. Data sources included program guidelines, course curricula, and study guides. A thematic approach was used to analyze the data based on a theoretical framework involving conceptual understandings, skills, and dispositions in summative assessment. The results indicate that all programs emphasize the basic assessment concepts such as validity and alignment and using assessment to inform teaching and learning. However, compared with formative assessment, summative assessment receives less attention in the curriculum. There are differences in addressing summative assessment through stand-alone and embedded courses and in the literacy areas covered. Implications for teacher education to address summative aspects of assessment in line with teachers’ tasks in schools are offered.
New metro and housing price and rent premiums: A natural experiment in China
Authors: He Dongsheng , Sun Guibo , Li Ling , Webster Chris
Published: December 2023

Causal evidence of housing premiums of new metro lines is indispensable for financing and governing infrastructure investments. Previous studies have investigated the housing effects of urban rail transit with varying methods, while causality remains unsettled. This study used a natural experiment to estimate the causal effects of the new metro interventions on housing premiums in Shenzhen, China. We used metro planning knowledge, reasoning on pursuits in land finance and engineering efficiency to verify the as-if randomness of the treatment–control group assignment in the natural experiment to reinforce the power of causal inference. We applied hedonic difference-in-difference (DID) models to estimate the average treatment effects based on the longitudinal housing price and rent data. We found that housing rents increased significantly and consistently after the metro entered operation, but the price premium varied. In addition, the rent premiums around new metro lines showed a price gradient over the distance to stations. Our findings provide scientific evidence for designing value capture mechanisms (e.g. value-added property tax and rent revenue) to recover metro investment costs in China.
Mixed methods, single case design, feasibility trial of a motivational conversational agent for rehabilitation for adults with traumatic brain injury
Authors: Hocking Judith , Maeder Anthony , Powers David , Perimal-Lewis Lua , Dodd Beverley , Lange Belinda
Published: December 2023

Objective

Rehabilitation for adults with traumatic brain injury (TBI) incorporates client-centred goal-setting and motivational support to achieve goals. However, face-to-face rehabilitation is time-limited. New therapy approaches which leverage care are warranted. Conversational agents (CAs) offer a human–computer interface with which a person can converse. This study tested the feasibility, usability and acceptability of using a novel CA – RehabChat – alongside brain injury rehabilitation.

Design

Mixed methods, single case design, feasibility pilot trial.

Setting

Ambulatory and community brain injury rehabilitation.

Participants

Adults with TBI receiving brain injury rehabilitation and clinicians providing this care.

Intervention

Following 1:1 training, client–clinician dyads used RehabChat for two weeks alongside usual care.

Main measures

Pre-post clinical measures (Motivation for Traumatic Brain Injury Rehabilitation Questionnaire, Rehabilitation Therapy Engagement Scale, Brain Injury Rehabilitation Trust Motivation Questionnaire-Relative, Brain Injury Rehabilitation Trust Motivation Questionnaire-Self) repeated measures (Hospital Anxiety and Depression Scale, researcher-developed wellbeing screening questions); and post-intervention (System Usability Scale (SUS), semi-structured 1:1 interview).

Results

Six participants (two clients and four clinicians) completed training. Two client–clinician dyads completed the intervention. Two other clinicians used RehabChat in a mock client–clinician session. SUS scores indicated good usability. Client well-being did not deteriorate. No adverse events were experienced. Interviews indicated RehabChat was feasible, acceptable and easy to use; and supported motivation, goal-setting and completing practice activities.

Conclusions

RehabChat was feasible and acceptable to use alongside usual ambulatory and community brain injury rehabilitation, had good usability and supported client needs. Further testing of RehabChat with a larger cohort for longer duration is warranted.
Healthcare professionals’ experiences of delivering a stroke Early Supported Discharge service – An example from Ireland
Authors: O Connor Elaine , Dolan Eamon , Horgan Frances , Galvin Rose , Robinson Katie
Published: December 2023

Objective

To explore healthcare professionals’ experiences of the development and delivery of Early Supported Discharge for people after stroke, including experiences of the COVID-19 pandemic.

Design

Qualitative descriptive study using one-to-one semi-structured interviews. Data were analysed using reflexive thematic analysis.

Setting

Nine Early Supported Discharge service sites in Ireland.

Participants

Purposive sampling identified 16 healthcare professionals.

Results

Five key themes were identified (1) Un-coordinated development of services, (2) Staff shortages limit the potential of Early Supported Discharge, (3) Limited utilisation of telerehabilitation post COVID-19 pandemic, (4) Families need information and support, and (5) Early Supported Discharge involves collaboration with people after stroke and their families.

Conclusions

Findings highlight how Early Supported Discharge services adapted during the COVID-19 pandemic and how gaps in the service impacts on service delivery. Practice implications include the need to address staff recruitment and retention issues to prevent service shortages and ensure consistent access to psychology services. Early Supported Discharge services should continue to work closely with families and address their information and support needs. Future research on how telerehabilitation can optimally be deployed and the impact of therapy assistants in Early Supported Discharge is needed.
Abuse potential assessment of the dual orexin receptor antagonist daridorexant in rats
Authors: Steiner Michel A , Toeroek-Schafroth Michael , Giusepponi Maria Elena , Dacome Lisa , Tessari Michela
Published: December 2023

Background:

Drugs that act on the central nervous system (CNS) and have sedative effects can lead to abuse in humans. New CNS-active drugs often require evaluation of their abuse potential in dedicated animal models before marketing approval. Daridorexant is a new dual orexin receptor antagonist (DORA) with sleep-promoting properties in animals and humans. It was approved in 2022 in the United States and Europe for the treatment of insomnia disorder.

Aims:

Nonclinical evaluation of abuse potential of daridorexant using three specific rat models assessing reinforcement, interoception, and withdrawal.

Methods:

Reinforcing effects of daridorexant were assessed in an operant rat model of intravenous drug self-administration. Similarity of interoceptive effects to those of the commonly used sleep medication zolpidem was tested in an operant drug discrimination task. Withdrawal signs indicative of physical dependence were evaluated upon sudden termination of chronic daridorexant treatment. Rat experiments were conducted at a dose range resulting in daridorexant plasma concentrations equaling or exceeding those achieved at the clinically recommended dose of 50 mg in humans.

Results:

Daridorexant had no reinforcing effects, was dissimilar to zolpidem in the drug discrimination task, and did not induce any withdrawal-related signs upon treatment discontinuation that would be indicative of physical dependence.

Outcomes:

Daridorexant showed no signs of abuse or dependence potential in rats. Our data indicate that daridorexant, like other DORAs, has a low potential for abuse in humans.
Desiring the state: Social welfare and kinship in post-socialist Tanzania
Authors: Haberland Nina
Published: December 2023

Every day, from Monday to Friday, women, men, and children sit on the uncomfortable benches outside the Tanzanian social welfare office and wait patiently for hours to meet with a welfare officer. There are mothers claiming alimony payments, fathers seeking visiting rights, quarrelling spouses, minors with legal problems, and families disputing inheritances. Most are ineligible for benefits, so this article asks why they nonetheless accept state practices of subordination like waiting. Based on case studies from 12 months of ethnographic fieldwork in the Department of Health in a northern district of Tanzania, I argue that queuing outside the welfare office signifies a ‘desire for the state’ as proposed by Street. To understand this desire, I explore the relationship between welfare clients and the state using the lens of post-socialism, specifically Verdery’s concept of ‘socialist paternalism’. This article explores kinship, the state, and the negotiation of responsibility in relation to the paternalistic images of the state reproduced by the ruling party, and argues that welfare clients appropriate these in search of care, advice, and guidance to address family and kin-related crises.
Entangled navigations: Intergenerational care relations in neoliberal eduscapes in Benin
Authors: Alber Erdmute
Published: December 2023

Though often overlooked, parental navigations play an important role in the difficult pathways of rural children through changing eduscapes in northern Benin. Arguing that parents are deeply involved in their children’s trajectories towards making a living, I analyse the care and support parents see themselves as responsible for. A neoliberal and increasingly privatized schooling system creating unequal chances in combination with the demand of ‘Education for all’ responsibilizes parents for their children’s success, and a tight labour market makes it additionally difficult for youth to find positions in the urban space. In consequence, parents are more intensively investing in their children’s education and related costs than ever before, without feeling that these investments lead to what parents value as success. Due to the lack of parental experience in the neoliberal eduscapes and the lack of cultural and social capitals – parents describe it as ‘blindness’ – parental actions in the eduscapes could best be described as navigations which are entangled with those of their children. In these navigations, parents give their children what they never received from their own parents, but also expect or hope them to become what they never were. Both parents and children navigate, I argue, towards an unknown and uncertain future in ‘radical openness’.
Kinship and the politics of responsibility: An introduction
Authors: Donner Henrike , Goddard Victoria
Published: December 2023

This special issue presents a range of case studies that exemplify the potential of kinship for thinking about and acting in relation to various kin and non-kin others in ways that invite us to reconsider the boundaries of politics and the political. The introduction examines ethnographic research that informs the articles in the special issue and shows the ways in which tensions and continuities across relations of intimacy, family and kinship, play out in response to contemporary capitalism. The articles in the special issue demonstrate the usefulness of exploring the interface and overlaps between the political and other fields that are all too often positioned – within scholarship and public discourses – as the antithesis of the political, variously understood in terms of the private, the familial, the domestic and the sphere of kinship.
Rammohun Roy and the ‘Conservative’ Overtones of His Liberal Sociopolitical Agenda
Authors: Basu Partha Pratim
Published: December 2023

Rammohun Roy, the liberal reformer of the early nineteenth century, and perhaps the first Indian to comprehensively embrace the ideal of modernity, encountered a volley of criticisms during his lifetime and beyond. Of all this, the twin charges, that is, his reformist project denigrated India’s ancient sociocultural heritage and he acted as an unconscious tool of the British Empire in India, have recently gathered a new momentum in the context of the changing dynamics of Indian politics. This article seeks to engage with this line of argument by examining the political, social and religious dimensions of Roy’s thought and action. It is accepted that he was inspired by the ideals of Western modernity, which, he believed, held the key to the long-term intellectual, sociocultural, political and economic development of the Indians. He also supported the continuation of British rule at least for a period of time to allow wider dissemination of these progressive values in India and to pave the way for its all-round advance. It is contended, however, that neither did he intend to undermine India’s classical heritage, nor did he favour mindless aping of the West. On the contrary, he took ample care to integrate indigenous sociocultural components into his proposed roadmap for the future. Thus, his liberal agenda had evident ‘conservative’ underpinnings that arguably put a new spin on the idea of modernity.
Covalent bonding of quaternary ammonium compounds and zwitterionic polymer functional layers on polydimethylsiloxane against Escherichia Coli adhesion
Authors: Chen Zi-Ti , Lee Bor-Shiunn , Tu Tsung-Han , Chan Yi-Tsu , Chang Che-Chen
Published: December 2023

Quaternary ammonium compounds (QACs) are recognized by the World Health Organization as a useful disinfectant against microbes. The synergistic effect of zwitterionic polymers with QACs as antimicrobial agents rather than QACs alone is yet to be investigated. A potential strategy is the use of covalent bonding to halt the release of minute antibacterials and a hierarchy of functional layers to detain and annihilate microbes. The strategy was tested on a polydimethylsiloxane (PDMS) surface on which quaternized poly(2-dimethylaminoethyl methacrylate) (qDMA+) and sulfobetaine (SBMA) were hierarchically functionalized. Attenuated total reflectance Fourier transform infrared analysis confirmed the quaternization of DMA to qDMA+, grafting of qDMA + on PDMS (PDMS-qDMA+), and grafting of the SBMA overlayer on PDMS-qDMA+ (PDMS-qDMA+-SB). Contact angle measurement showed that PDMS-qDMA + exhibited the lowest contact angle (26.2 ± 2.9°) compared with the hydrophobic PDMS (115.2 ± 1.6°), but that of PDMSqDMA+-SB increased to 56.3 ± 1.3°. The Escherichia coli survival count revealed that PDMS-qDMA+ and PDMS-qDMA+-SB exhibited significantly greater bactericidal ability than PDMS. Confocal laser scanning microscopy revealed fewer dead bacteria on PDMS-qDMA+-SB than on PDMS-qDMA+. Scanning electron microscopy demonstrated that E. coli was disintegrated on the functionalized surface via dual-end cell lysis. To the best of our knowledge, this is the first observation of this type of process. The results confirmed the potent antibacterial and cell disruption activities of the qDMA+ and SBMA modified PDMS surface.
The Lived Experience of Racism in the Sikh Community
Authors: Brewer Gayle , Singh Jatinder , Lyons Minna
Published: December 2023

The Sikh community may be more visible and vulnerable to racism than other religious groups, and previous research has documented the racism targeted at Sikh men and women in the United States. Relatively few studies have, however, addressed the racism experienced by Sikh communities in other countries, where racism may be less closely connected to the events of 9/11. The present study investigates the lived experience of racism in Sikh adults living in the United Kingdom. Six participants (5 male, 1 female) aged 19 to 30 years ( M = 24.17, SD = 3.98) were recruited via advertisements placed on social media. Both Amritdhari Sikhs ( n = 4) who had undertaken the Amrit Sanskar initiation ceremony or commitment and Sahajdhari Sikhs ( n = 2) who had not undertaken the initiation participated. Semi-structured interviews were conducted (totaling 372 minutes of interview data), covering a range of subjects including personal experiences of racism and subsequent responses to the racist abuse. Interpretative Phenomenological Analysis of the interview transcripts identified five superordinate themes. These were (1) Appearance and Visibility; (2) Inevitability and Normalization; (3) Coping and Conformity (Religion as Support, Fitting In, Internalization); (4) Education and Understanding; and (5) Bystander Behavior (Experiences of Intervention, Religious Duty to Intervene, Consequences of Intervention). Findings highlight the extent to which racism occurs and the increased vulnerability of the Sikh community (e.g., appearance being the focus of racist abuse). Findings also highlight the importance of religion as a source of support and cultural pride and the significance of education and bystander behavior. Future research should further investigate these themes and introduce interventions to support the safety and well-being of members of the Sikh community experiencing racist abuse.
Sex Sells Terrorism: How Sexual Appeals in Fringe Online Communities Contribute to Self-Radicalization
Authors: Britt Brian C.
Published: December 2023

The past several years have seen rising hate crimes, terrorist attacks, and broader extremist movements, with news reports often noting that these movements can be traced back to fringe online communities. Yet the question remains why such online groups appear more likely to foster radicalization than those in other contexts. This netnographic case study demonstrates how sexual appeals in fringe online communities facilitate the development of extremist ideologies. Specifically, the cognitive effects of sexual arousal combined with the social norms of such communities contribute to the acceptance of hate speech and fringe ideologies while reducing the extent to which audiences evaluate rational arguments and competing points of view. Thus, sexual appeals paired with messaging or imagery that promotes fringe points of view, which can be more freely expressed in small online groups than in other contexts, are more likely to result in intended attitudinal and behavioral changes—in other words, extremism.
“A novel methodology for developing ultra-low adhesion leaf layers on a full-scale wheel/rail rig”
Authors: Jaffe Joseph , White Ben , Lanigan Joseph , Lewis Roger
Published: December 2023

This paper explores a novel method for creating an ultra-low adhesion leaf layer on a rail using a full-scale wheel/rail rig. Ultra-low adhesion layers were generated using leaf powder for the first time on a linear full-scale rig. The layers are compared chemically and physically to other layers from the laboratory and field. Testing of the adhesion evolution of the leaf contaminated layers over 50 cycles is explored, and compared to dry and wet rails.
Spacecraft autonomous navigation using line-of-sight directions of non-cooperative targets by improved Q-learning based extended Kalman filter
Authors: Xiong Kai , Zhou Peng , Wei Chunling
Published: December 2023

Autonomous optical navigation is one of the most promising techniques to estimate the position and velocity of a spacecraft in Earth orbit without the supports of Earth-based tracking stations. To improve the navigation performance, this paper presents a novel autonomous optical navigation method, where a star camera on the spacecraft is utilized to measure the line-of-sight (LOS) directions of a number of non-cooperative space targets, whose position vectors are supposed to be not precisely known in advance, and an improved Q-learning based extended Kalman filter (IQEKF) is developed to obtain the accurate motion state estimate of both the spacecraft and the space targets based on the LOS direction measurements. The main advantage of the presented method is that the LOS directions of the space targets can be acquired with high-accuracy by using the state-of-the-art star camera, such that the superior navigation accuracy is achievable. In addition, the whole motion state of the spacecraft, such as position, velocity, and attitude, can be obtained with the star camera, in the case that the space targets and the stars are observed simultaneously. The high performance of the presented autonomous navigation method is illustrated through a representative simulation of a medium Earth orbit (MEO) satellite. Furthermore, the simulation results indicate that the IQEKF yields more accurate solutions than the traditional navigation filtering algorithms.
Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis
Authors: Zhang Ying , Fang Qian , Liu Yinan , Zhang Dan , He Ying , Liu Fei , Sun Kun , Chen Jinghong
Published: December 2023

This study evaluated the effect of fibroblast growth factor receptor 3 (FGFR3) on damaged hypertrophic chondrocytes of Kashin–Beck disease (KBD). Immunohistochemical staining was used to evaluate FGFR3 expression in growth plates from KBD rat models and engineered cartilage. In vitro study, hypertrophic chondrocytes were pretreated by FGFR3 binding inhibitor (BGJ398) for 24 h before incubation at different T-2 toxin concentrations. Differentiation -related genes (Runx2, Sox9, and Col Ⅹ) and ECM degradation -related genes (MMP-13, Col Ⅱ) in the hypertrophic chondrocytes were analyzed using RT-PCR, and the corresponding proteins were analyzed using western blotting. Hypertrophic chondrocytes death was detected by the Annexin V/PI double staining assay. The integrated optical density of FGFR3 staining was increased in knee cartilage of rats and engineered cartilage treated with T-2 toxin. Both protein and mRNA levels of Runx2, Sox9, Col Ⅱ, and Col Ⅹ were decreased in a dose-dependent manner when exposed to the T-2 toxin and significantly upregulated by 1 μM BGJ398. The expression of MMP-1, MMP-9, and MMP-13 increased in a dose-dependent manner when exposed to T-2 toxin and significantly reduced by 1 μM BGJ398. 1 μM BGJ398 could prevent early apoptosis and necrosis induced by the T-2 toxin. Inhibiting the FGFR3 signal could alleviate extracellular matrix degradation, abnormal chondrocytes differentiation, and excessive cell death in T-2 toxin-induced hypertrophic chondrocytes.
The efficacy of part-time patching treatment for intermittent exotropia on different age groups
Authors: Alkharashi Maan , Aldokhayel Fares , Alekrish Yazeed , Alotaibi Mohammed , Almazyad Laith Mazyad , Bajeaifer Yazen
Published: December 2023

Background

Intermittent exotropia (IXT) is one of the most common forms of strabismus usually seen in the pediatric age group, the prevalence of IXT is higher in Africa and the Middle East. IXT treatment strategies include both surgical and non-surgical methods, non-surgical management is preferred in general as it is less invasive and avoids the risks associated with surgery and anesthesia.

Aims

This study aims to determine the effectiveness of patching therapy for the treatment of IXT in different age groups and to compare the success of patching therapy in preventing surgery in IXT patients in different age groups.

Methodology

A retrospective chart review was conducted from September 2022 until February 2023 at King Abdulaziz University Hospital in Riyadh. The data was collected retrospectively from electronic medical records from 2016 to 2021 of all patients diagnosed with IXT and were managed by patching therapy fitting the inclusion criteria.

Results

A total of 76 patients with IXT enrolled in the study with 56.5% of the participants were older than 7 years old. Overall, there was no improvement in the angle of deviation but 34% of patients had improved control over the follow-up period. 55.3% of the participants didn't require surgery. Younger age, longer duration of patching per month, and good compliance were significantly associated with treatment success.

Conclusion

Younger age groups were more likely to benefit from patching therapy than older age groups, and good compliance to patching therapy is an important factor in preventing the need for surgery.
Development of a highly various warp yarn manipulation system for the fabrication of 2D net-shape non-crimp-fabrics for highly material efficient concrete reinforcements
Authors: Penzel Paul , Hahn Lars , Klug Peter , Cherif Chokri
Published: December 2023

Textile reinforcements have revolutionized many industries, most of all aerospace, automotive and building. Due to its high performance and the significant increased lightweight potential, they have established themselves as an efficient and sustainable alternative to conventional materials. However, in view of the increasing demand of an ever growing population in contrast to a scarcity of resources and urge of material efficiency in the face of climate change, novel technologies for highly material efficient products in large-scale productions are required. In this regard, a major research field involves the multiaxial warp-knitting technique for the production of high performance textile preforms. In several steps, this technology has been further developed to enable the production of application-specific and bionic-inspired textile preforms, which are characterized by a force compliant and multi-material design. Yet the structural possibilities are still limited. This article presents a novel developed warp yarn manipulation system for multiaxial warp-knitting machines. The system enables the fabrication of 2D net-shape non-crimp-fabrics (NCF) made of up to 16 single warp yarns that specify by an alternating diagonally offset and overlapping edge-strand. This structure is suitable for the use as textile lattice girder for reinforcing concrete slab structures Hereby the developed warp yarn manipulation system allows highly various structural parameters of the 2D net-shape NCF for highest material efficiency and product variety. The technological development is discussed in means of the constructive and electronic control design as well as a specific application example for new net-shape reinforcement structures.
TRIM28 suppresses cancer stem-like characteristics in gastric cancer cells through Wnt/β-catenin signaling pathways
Authors: Ning Tingting , Zhao Mengran , Zhang Nan , Wang Zhaoqing , Zhang Shutian , Liu Mo , Zhu Shengtao
Published: December 2023

The influences of TRIM28 on the gastric tumorigenesis together with potential molecular mechanisms remain to be studied. We aimed at exploring the important effects of TRIM28 on gastric cancer (GC) and uncovering underling molecular mechanisms. Through immunohistochemistry analysis of 20 pairs of GC and the peritumoral tissues, the expression level of TRIM28 was determined. A variety of assays were applied to explore the important roles of TRIM28 in GC. Western blotting and qRT-PCR analyses were used to analyze the association between TRIM28 and the Wnt/β-catenin signaling pathway. TRIM28 was highly expressed in GC tissues than peritumoral tissues. And high expression level of TRIM28 in GC was associated with good prognostic effects. In vitro functional assays suggested TRIM28 knockdown enhanced the proliferation and clone formation of GC cell. Moreover, TRIM28 knockdown enhanced the expression level of stemness markers, strengthened sphere-forming and drug-resistance properties of GC cells, suggesting important effect on GC cell stemness. Besides, our analysis showed that the Wnt/β-catenin signaling was involved in the effect of TRIM28 on GC cell stemness property, and blocking Wnt/β-catenin signaling pathway obviously rescued the promotion influence of TRIM28 knockdown. Overall, TRIM28 has an important influence on regulating the stem-like property of GC cell via Wnt/β-catenin signaling, suggesting TRIM28 a promising drug target and a potential predictor of prognosis.
Pandemic-Induced Occupational Disruption and Association With Health in Japanese Community-Dwelling Older Adults
Authors: Uemura Jun-ichi , Uno Kohei , Hoshino Aiko , Sano Tatsuhiko , Tanikaga Miki , Tanaka Masahiro , Mizuno Junpei
Published: December 2023

The COVID-19 pandemic caused occupational disruption and adverse health outcomes in community-dwelling older adults. This study aimed to investigate the extent of occupational disruption in older adults and its relationship to health-related quality of life (QOL), depression, and frailty. In this cross-sectional study, retention rates in four activity domains and relationships with health outcomes were examined in Japanese older adults aged ≥65 years ( n=163) using canonical correlation analysis (CCA) and mixed linear models. More than 25% of activities were restricted compared with the pre-pandemic period. CCA demonstrated correlations between four retention rates and health outcomes (canonical correlation = .42, p = .0003). Retention in instrumental and social activities independently predicted QOL and depression ( p < .05). This study highlights that different activities may have different effects on health outcomes and can provide community occupational therapy practitioners with a perspective to assess occupational disruption and identify activities for intervention.
The Academic Basis of Lifestyle Medicine
Authors: Rippe James M.
Published: December 2023

There is no longer any serious doubt that daily habits and actions profoundly impact on both short- and long-term health and quality of life. An overwhelming body of scientific and medical literature supports this contention. Thousands of studies support the concept that regular physical activity, healthy nutrition and maintaining a healthy body weight, not smoking cigarettes, obtaining healthy sleep, reducing stress and maintaining positive connections with other individuals all profoundly impact on health. The scientific literature the supports the health impact of these daily habits and actions is underscored by its incorporation into virtually every evidence-based clinical guideline in the area of metabolic diseases. Thus, the scientific basis for lifestyle medicine rests on an enormous body of evidence-based literature. The key issue in lifestyle medicine is to provide an overall framework where these studies, which are often spread over scientific literature in multiple disciplines, can be made accessible to the medical community and to the public at large. This is the essence of the field of lifestyle medicine. The academic basis of lifestyle medicine is robust and needs to be emphasized by all practitioners of lifestyle medicine. This is the key to moving this field forward into the future.
Inductive Process to Analyze the Structure of Lived Experience: A Scholar-Practitioner Protocol for Evidence-Based Practice in Qualitative Research
Authors: Behal Anil
Published: December 2023

One of the criticisms leveled against research and knowledge, especially "knowledge for knowledge’s sake" is that it seldom goes so far as to make a significant difference in practice. Thousands of doctoral graduates worldwide produce new knowledge every year, only to run out of steam at the end of their doctoral journey. For many, earning their doctorates is sufficient to justify the painstaking academic journey, so they give up the ghost and strive no more to make a difference. As 12th century French abbot St Bernard of Clairvaux writes, "Some seek knowledge for the sake of knowledge—and that is curiosity. Some seek knowledge that they may be known to have knowledge—and that is vanity. Some seek knowledge that they may give to others their knowledge—and that is charity." But how does one apply the knowledge to solve real-world problems? How does what you have learned and discovered, find its way into praxis? How does it find favor with organizational and community leaders who are not academically inclined and could not care less for academic theories and jargon? This paper is inspired by the work of a team of French researchers who have conceptualized and developed an innovative approach entitled "Inductive Process to Analyze the Structure of Lived Experience" (IPSE), which is being successfully integrated into evidence-based medicine (EBM). Taking a cue from EBM, an attempt is made to unpack and elucidate the IPSE framework for doctoral researchers that are unfamiliar with it and offer a compelling case for its application in the practice of social science research, outside the field of medicine.
Exploring the transformative power of dance: A scoping review of dance interventions for adults with intellectual disabilities
Authors: Dumitru Cristina
Published: December 2023

The aim of this scoping literature review (SCR) was to analyze the impact of dance on adults with intellectual disabilities, specifically examining its influence on their mobility, interpersonal relationships, well-being, and overall quality of life. A total of 15 papers were reviewed in order to explore the effects of dance on the well-being and quality of life of adults with intellectual disabilities. The findings indicated significant improvements in body awareness, increased engagement in physical activity, and enhanced mental health. This SCR demonstrates that dance is an effective means of facilitating social interaction among adults with intellectual disabilities, both with their therapists and family members. Additionally, the review uncovered valuable data on dance therapy programs designed for adults with intellectual disabilities, highlighting their potential to promote physical activity and reduce stress levels.
How Social Media Algorithms Shape Offline Civic Participation: A Framework of Social-Psychological Processes
Authors: Jung Haesung , Dai Wenhao , Albarracín Dolores
Published: December 2023

Even though social media platforms have created opportunities for more efficient and convenient civic participation, they are unlikely to bring about social change if the online actions do not propagate to offline civic participation. This article begins by reviewing the meta-analytic evidence on the relation between social media use and offline civic participation. Following this discussion, we present a theoretical framework that incorporates the attitudinal, motivational, and relational processes that may mediate the effect of social media use on offline civic participation. The framework highlights how social media algorithms may shape attitudes on important societal issues, promote generalized action goals among habitual users, and build social capital. We further discuss factors that may strengthen or undermine each of these processes, suggest ways to design and implement algorithms that may promote offline civic participation, and propose questions for future research.
Unpacking and unpicking the challenge of 600 hours of preschool attendance
Authors: Harrison Linda J , Redman Tracy , Brown Judith E , Lavina Leanne , Davis Belinda , Degotardi Sheila , Fordham Loraine , Hadley Fay , Jones Catherine , Waniganayake Manjula , Wong Sandie
Published: December 2023

The Australian Government’s (2022) Preschool Reform Funding Agreement and initiatives by state governments aim to lift enrolment and maximise the benefits of early childhood education (ECE) in the year before school. The Agreement is particularly relevant for children and families from vulnerable and disadvantaged backgrounds, many of whom do not utilise the annual attendance target of 600 hours available to every child. Children’s enrolment and daily attendance records are key to understanding participation in ECE, but few studies or government reports have examined this information in detail. Drawing on administrative records provided by 19 long day care and preschool centres/schools in areas of socio-economic disadvantage, we analysed weekly attendance for 971 preschool-aged children over four 10-week terms. Results for the ‘percentage of enrolled days’ attended (M = 88%) and ‘total hours’ attended (M = 576 h) approached the target but differed for children enrolled in preschool versus long day care.
The Role of the School Nurse in Addressing Climate-Associated Illnesses: Mental Well-being
Authors: Oerther Sarah , Berkley Amy , Reangsing Chuntana
Published: December 2023

Human health is being impacted by anthropogenic (human-made) climate change. This article describes four ways that climate change may affect mental well-being in school-age children. First, natural disasters—such as more frequent and intense tornadoes and flash floods—may have a direct influence on mental well-being by contributing to acute anxiety and distress. Second, indirect effects of severe weather—including changes in social support systems—may affect mental well-being by increasing isolation. Third, children may suffer feelings of anxiety or depression if they perceive a sense of powerlessness to solve the challenges of a changing climate. Finally, school nurses need to be aware of the emergence of correlations—such as data that suggest increases in temperature may influence the use of inpatient mental health services and suicidal ideations—that require further scientific exploration. This article aims to increase school nurses’ understanding of how climate changes may impact the mental well-being of school-age children and to provide strategies for creating a safe, healthy learning environment. This article is the fourth in a series aimed at raising awareness among school nurses about climate-associated illnesses and equipping them with the resources they need to protect school-age children’s health.
A silence meant to be heard: LIGNA’s radio ballet
Authors: Wan Zheng
Published: December 2023

This article analyzes the role of sound in the transformation of social space and organization of noncentered group action through a case study of the series of radio ballets programmed by the German artist collective LIGNA. Typically, LIGNA uses portable audio devices and wireless technology to disseminate instructions to the radio ballet participants, directing them to make synchronized body gestures but not giving them fixed movement paths or identities. This process creates a conceptualized acoustic space parallel to the physical space, challenges the regulations that come with the privatization of public spaces, and dismantles the dichotomies between inside and outside, public and private, and physical and mental. I argue that the radio ballet participants, who form a decentralized, temporary, and mobile community, can explore new possibilities for political intervention in the public sphere through silent collective performances in which sound not only serves the important function of sidestepping visual censorship and avoiding physical conflict but also provides a new methodology for reshaping the order of social space.