bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of the microbial communities and treatment units in a waste stabilization pond system treating wastewater from an industrial complex located in Northeastern Brazil
Authors: Júnior Luiz Pereira Silva , Silva Bruna Kelly de Oliveira , Santos Nathália Bandeira Carvalho dos , de Araújo Natercia Correa , Amaral Fernanda Magalhães , Júnior Bartholomeu Siqueira , de Oliveira Fábio Henrique Portella Corrêa , Bortoleti Kyria Cilene de Andrade , Motteran Fabrício , Fernandes Bruna Soares , Vidal Ana Christina Brasileiro , Júnior Marcos Antônio de Morais , Gavazza Savia
Published: November 2024

The Multifactory Effluent Treatment Plant (ETE-MF), located within an industrial complex in Recife, Brazil, receives effluents from 15 industries from different sectors, as well as domestic wastewater. This plant is recognized as efficient by the state sanitation company. This raises the question of what are the causes of this scenario and whether this process could be replicated. In this sense, this research aimed to reveal the physicochemical aspects of the MF-WWTP and the microbial community that has established itself there during decades of operation. Overall, the results showed COD (Chemical Oxygen Demand) removal of 84.0% and COD/BOD (BOD - Biological Oxygen Demand) ratios of 1.78 and 5.79 for raw and filtered untreated effluents, respectively. The microbial community analysis showed that bacteria belonging to the Fervidobacterium genus was the most abundant in all sampled points in all ponds, with an average relative abundance of 64%. This organism belongs to the Thermotogaceae family, widely distributed in nature and frequently found in salt flats, oil and petroleum wells, refineries and biodigesters and seems to be crucial for the performance of the treatment plant. This polishing process was completed by the microalgae community found mainly in pond 3, where the community was mainly composed of the genera Cyclotella and Planktothrix. The results provided scientific evidence for the technical analysis that the MF-WWTP has bioremediation potential and indicates that this efficiency is due to the microbial composition of the system.
Comprehensive Prognostic and Immunoinfiltration Analysis in Esophageal Squamous Cell Carcinoma Patients Using a Combined EMT and Ferroptosis-Related Biomarker Signature
Authors: Wang Zhidong , Gong Cheng , Chao Ce , Zhang Youpu , Qian Yiongxiang , Wang Bin , Wang Min , Liu Yang
Published: November 2024

Background
Limited research has been conducted on the interaction between ferroptosis and epithelial-mesenchymal transition (EMT) and their combined effect on esophageal squamous cell carcinoma (ESCC) patient prognosis. The present study aimed to develop a prognostic model based on the impact of ferroptosis and EMT on ESCC prognosis for clinical application.
Methods
Gene expression levels and clinical data of ESCC patients were obtained from the GSE53625 dataset in the Gene Expression Omnibus (GEO) database, and the data from the Cancer Genome Atlas (TCGA) were obtained as a validation set. By combining the results of Cox regression analysis and least absolute shrinkage and selection operator regression (LASSO) analysis, we selected nine genes associated with prognosis, which were then used to construct a prognostic model. Immune cell infiltration was evaluated using CIBERSORT and single-sample Gene Set Enrichment Analysis methods. Finally, in vitro experiments were conducted to assess the oncogenic effects of ACSL3 and VIM.
Results
Nine key genes were screened to construct ferroptosis and EMT integrated score (FEIS). Compared to the low-FEIS group, the high-FEIS group demonstrated shorter overall survival period. The immune infiltration analysis showed an increase in immune cell infiltration and elevated expression levels of immune checkpoint molecules in the high-FEIS group. A nomogram was constructed to accurately predict patient prognosis. Additionally, our in vitro experiments confirmed the oncogenic effects of ACSL3 and VIM.
Conclusion
Our study introduced a novel prognostic tool that integrates ferroptosis -and EMT-related biomarker, and offered valuable insights for developing personalized treatment strategies for ESCC patients.
Genomics on FHIR – A Feasibility Study of an interoperable genomics dataset to support the German National Strategy for Genomic Medicine
Authors: Haffer Nina , Stellmach Caroline , Sass Julian , Muzoora Michael R , Graefe Adam SL , Thun Sylvia , Vorisek Carina N
Published: November 2024

The German National Strategy for Genomic Medicine (genomDE) project aims to establish a nation-wide platform for medical genome sequencing to integrate genome sequencing into standard health care. Connecting information of genomics data generated by research and healthcare remains challenging due to the complexity of data and lack of standardization. Fast Healthcare Interoperability Resources® (FHIR)® is a standard for exchanging healthcare information electronically that has gained worldwide adoption within healthcare systems. This study analyzed how a dataset defined by stakeholders in genomDE could be mapped established international standards: the Genomics Reporting FHIR implementation guide (IG) version 2.0.0 that was created by Health Level Seven (HL7)’s Clinical Genomics working group, the Global Alliance for Genomics and Health (GA4GH)’s Phenopacket Schema, as well as the German Medical Informatics Initiative’s (MII) molecular genomics report IG. In addition, sample FHIR bundles and necessary search queries were created and validated. We concluded that most dataset items defined by the genomDE projects could be represented in FHIR, using preexisting FHIR profiles. For dataset elements for which no prior FHIR mapping existed, we could show that it was possible to extend the existing specifications through profiling of additional FHIR resources and the use of extensions. This study highlights that the identification and use of preexisting FHIR specifications increases interoperability and builds efficiencies in connecting genomics data models on an international level while considering national requirements.
Osteosynthesis with allograft screws in pediatric orthopedics: preliminary results
Authors: Gutierrez-Pereira Javier , Santos Flavio Paulos dos , Gutierrez-Carbonell Pedro , Garcia-Lopez Antonio
Published: November 2024

Background
A significant percentage of patients develop complications related to the use of implants made of stainless steel or titanium. The purpose of our study is to retrospectively analyze the clinical and radiological outcomes of allograft screws implanted in the Pediatric Orthopedic unit of our center.
Materials and Methods
A retrospective analysis was conducted, including 30 patients (16 females, 14 males) with lower limb pathologies who received 50 human cortical bone allograft screws. The study period covered 24 months, from January 1, 2020, to January 1, 2023. The average age was 12 years 7 months (range 3, 15 years). The mean follow-up was 14 months (range 8–24).
Results
After an average follow-up of 14 months, no patients developed minor or major complications, delayed union, or infections. Three patients reported discomfort due to implant prominence, and two of them (7%) required reoperation for screw head remodeling. The average resorption time was 9 months (range 5, 15 months). The postoperative AOFAS score increased by 38.28 points (statistical study) compared to the preoperative score.
Conclusion
Cortical bone allograft screws are an effective and safe osteosynthesis method for lower limb pathologies in pediatric orthopedics. It is important to avoid implant prominences that may cause discomfort to the patient and potentially require reoperation.
Bronchoalveolar Lavage Proteomics in Acute Exacerbation of Bronchiectasis
Authors: Lee Ju Yeon , Yang Jiyoul , Kim Jin Young , Do Yeji , Kim Min-Sik , Kye Dong Eun , Min Geonhui , Jeon In-Sook , Kim Eung-Gook , Choi Joong Kook , Lee Hyun , Yang Bumhee
Published: November 2024

Background: The molecular pathophysiology underlying the development of bronchiectasis with acute exacerbation at the proteomic level has not been clarified using bronchoalveolar lavage fluid samples. This study aimed to evaluate the bronchoalveolar lavage fluid inflammatory profiles associated with acute exacerbation of bronchiectasis.
Methods: We analyzed the bronchoalveolar lavage fluid specimens from 4 patients in the acute exacerbation status and 4 patients in a stable status using liquid chromatography-tandem mass spectrometry.
Results: A total of 1,577 proteins were identified using proteomic analysis, with 127 differentially expressed proteins. Of 127 differentially expressed proteins, 23 proteins showed more than 2-fold differences between the acute exacerbation and stable status groups. The acute exacerbation status was associated with 18 upregulated proteins (TPI1, CRP, BPI, ORM1, PTPRE, S100A9, BPY2, TPM4, ERVFC1-1, CYS1, CLEC3B, S100A8, PSAT1, NDUFA10, MDGA1, SPRR3, ALDOA, and PSMB2)and five downregulated proteins (MUC5B, HSPE1, KLK13, IGHA1, and MUC5AC). Pathway analysis revealed that the neutrophil degranulation pathway (R-HSA-6798695) was the most enriched pathway in these proteins, followed by the C-type lectin receptor pathway (R-HSA-5621481).
Conclusion: The bronchoalveolar lavage fluid protein expression in patients in the acute exacerbation status of bronchiectasis was significantly different from that in patients in the stable status, indicating that neutrophil degranulation and C-type lectin receptor pathways are the most enriched pathways during acute exacerbation.
Evaluation of Kosmic and Expectation-Maximization algorithms and different data pre-processing approaches to determine Upper Reference Limits for Insulin in adolescents
Authors: Freire Monica Di Calafiori , Dias Paulo Roberto Telles Pires , Arcuri Leonardo Javier , Souza Thiago Silva Pereira , Hirose Caio Kenji , Araujo Paula Bruna Mattos Coelho , Neves Mario Fritsch Toros
Published: November 2024

Background
The International Federation of Clinical Chemistry considers the a priori direct method the gold standard to laboratory reference interval (RI) determinations. However, this can be significantly challenging in the real world. Indirect methods may be more realistic tools to determine RI specific to local populations. More recently developed Kolmogorov-Smirnov distance and Expectation-Maximization mixture model separation methods are free from the implicit subjectivity of the earliest graphic indirect methods available. Objective: To evaluate the performance to establish upper reference limit (URL) for insulin in Brazilian adolescents, from 12 to 17 years old, by 2 indirect algorithms and 3 data pre-processing approaches, compared to a directly obtained URL.
Methods: This study was approved by the Ethics Committee of the Pedro Ernesto University Hospital, under the document number: 2.970.023. Data set 1 (DS1), used to obtain URL through direct method, consisted of individuals from ERICA Study, after exclusion of “not healthy” individuals according to available data. Data set 2 (DS2) also consisted of individuals from the Erica Study without application of any exclusion criteria, was submitted to Kolmogorov-Smirnov (Kosmic) and Expectation-Maximization (EM) algorithms, in 3 pre-processing settings. URL were compared through bias ratio (BR).
Results: DS1 and DS2 consisted of 14835 and 37892 individuals, 57.7% (n = 8559) and 60% (n = 22729) were female, respectively. Distribution was not normal in both data sets. URL by Kosmic and EM without data pre-processing were lower than the direct URL for all partitions. On log-transformed DB2 indirect calculations, Kosmic method URL was lower than the DB1 direct ones, except in one partition. EM and direct URLs were similar. When DB2 was submitted to Cox-Cox transformation, indirect URL were lower than the direct ones. EM BR results fitted below 0.375 in all partitions when data were log-transformed. Kosmic BR results were not consistently below the BR threshold.
Conclusion: EM algorithm determined FBI URL after log-transformation outperformed the Kosmic method and other pre-processing approaches, when compared to gold-standard URL. These findings can be explained by the right skewness of the FBI distribution.
In utero impacts of airway exposure to silver nanoparticles on male reproductive function in two generations of mice
Authors: Yokota Satoshi , Kawakami Tsuyoshi , Yoshioka Hiroki , Moriya Nozomu , Sekine Nao , Miura Nobuhiko , Kitajima Satoshi , Ichinose Takamichi , Oshio Shigeru
Published: November 2024

Considering the transgenerational inheritance of epigenetic information and the negative effect of nanoparticle exposure on male fertility, this study investigated the in utero effects of exposure of airway to silver nanoparticles (AgNPs) on male reproductive function. Exposure of pregnant mice to AgNPs (low dose: 5 µg/injection; high dose: 50 µg/injection) at embryonic day 7.5 and 14.5, by intratracheal administration, resulted in dose-dependent exacerbation of sperm parameters in both F1 and F2 males. Microarray analysis revealed significant upregulation of four microRNAs (miRNAs) and downregulation of seven miRNAs in the testes of F1 males in the high-dose group compared to those in the control group, and these results were further verified using quantitative real-time PCR. Interestingly, in the mature sperm as well, the high-dose group displayed significant upregulation of one and downregulation of three of the miRNAs dysregulated in the testes. Notably, in silico analyses predicted that the genes targeted by the differentially expressed miRNAs in the sperm were significantly associated with neuronal development. Neuronal migration in the cerebral cortex was dysregulated in the F2 males and was accompanied by depression-like behavior. This is the first report of prenatal exposure to AgNPs inducing germ cell development dysfunction in F1 males, which is involved in developmental toxicity in the F2 males born to these F1 males.
Depression as a Risk Factor for Gynecological Cancers: Evidence from a National Study
Authors: Wang Chaoyi , Xu Jin , Li Xiaodan , Jiang Lijuan
Published: November 2024

Background: Depression is one of the leading sources of disease burden globally and plays a significant role in the occurrence and development of many cancers, representing an important health risk. However, the relationship between depression and the risk of gynecologic cancers has not been fully assessed.
Objective: This study aims to explore the association between depression and the risk of gynecologic cancers.
Methods: The study selected 11,574 participants from the NHANES 2009-2018 cycles, among which 274 had gynecologic cancer (GC), 137 had cervical cancer (CC), 48 had ovarian cancer (OC), and 89 had endometrial cancer (EC). Box plots were used to assess the differences in PHQ-9 depression scores between cancer and non-cancer groups. Logistic regression models and restricted cubic spline (RCS) models were employed to evaluate the relationship between PHQ-9 scores and gynecologic cancers. Subgroup analyses and interaction tests examined the consistency of the association across different characteristics.
Results: There was a significant difference in PHQ-9 scores between the cancer group and the non-cancer group. In the multivariable logistic regression analysis, PHQ-9 scores were positively correlated with GC, OC, and EC, while no significant association was found with CC risk. The RCS model also indicated no nonlinear association. Additionally, subgroup analyses suggested that the relationship between PHQ-9 scores and CC and OC was consistent across groups, whereas the association between PHQ-9 scores and GC and EC showed heterogeneity in relation to race and marital status.
Conclusion: Depression is positively correlated with gynecologic cancers. Specifically, higher levels of depression are associated with an increased risk of OC and EC, while no significant association was found with CC risk. Future attention should be given to the impact of depression on the incidence of gynecologic cancers, particularly OC and EC.
Impact of ACE on Emotional Regulation and Future Time Perspectives in Borderline Personality Disorder: Mediating and Moderating Roles of Parental Involvement
Authors: Nayar Sonakshi , George Angeline Miriam , K Suvarna Jyothi
Published: November 2024

Background: Adverse Childhood Experiences (ACEs) are known to have significant psychological and physiological impacts on various aspects of adult life. This study aimed to examine the influence of ACEs on Emotional Regulation (ER) and Future Time Perspective (FTP) in young adults diagnosed with Borderline Personality Disorder (BPD) within an Indian context.
Method: The study explored the mediating and moderating roles of Parental Involvement in these relationships. A sample of 40 young adults, both male and female, from the Inpatient and Outpatient Departments of Psychiatry and Clinical Psychology from SRMC hospital, diagnosed with BPD, were assessed.
Result: The findings challenge established theoretical frameworks by showing that whereas ACEs strongly predict PI, neither ACEs nor PI were significant predictors of ER or FTP in this group. These results imply that the cultural setting, particularly the collectivist character of Indian society, may be a significant moderator of the psychological effects of early adversity in borderline personality disorder.
Conclusion: The paper also identifies other constraints that might have affected the results, such as a small sample size, gender imbalance, and cultural heterogeneity. Given the diversity in BPD symptomatology and the impact of culture, the study emphasizes the need for more research and interventions that are specifically suited to cultural differences.
MRI texture analysis of the lateral pterygoid muscle in patients with unilateral anterior disc displacement of the temporomandibular joint
Authors: Huang Tao , Zhao Shu-Fan , Song Zhi-Qiang , Gong Zhong-Cheng
Published: November 2024

Background
This study aimed to investigate the texture changes in the lateral pterygoid muscle (LPM) in patients with unilateral anterior disc displacement (uADD) of the temporomandibular joint with magnetic resonance imaging (MRI).
Methods
This retrospective study aimed to comparatively analyze the texture of the LPM in 232 patients with uADD from January 2022 to December 2023. Four groups were included in this study: the healthy joints of patients with uADD (H-TMJ), joints with anterior disc displacement (ADD) with reduction (ADDwR), joints with ADD without reduction (ADDwoR), and the joints of normal volunteers as the healthy group (HG). Five texture parameters were used for analysis: the angular second moment (ASM), contrast, inverse difference moment (IDM) and entropy.
Results
The average differences in the ASM, contrast, correlation, IDM, and entropy of the LPM between the joints of healthy individuals and those of individuals with uADD were − 1.16×10− 4, 7.65, 2.66×10− 5, 1.06×10− 2, and 9.21×10− 2, respectively, with P values less than 0.05, indicating statistical significance. The entropy values of the ADDwoR and ADDwR groups was 6.38×10− 2, with a statistically significant difference (P < 0.05). In addition, the H values for ASM, contrast, correlation, IDM, and entropy among the different degrees of disc displacement were 6.52, 15.45, 12.96, 7.72, and 11.66, respectively, with P < 0.05, indicating statistical significance. Through correlation analysis, the correlation coefficient between the disc displacement and the ASM was 0.082 (P > 0.05), with no statistical significance. The corresponding correlation coefficients for contrast, correlation, IDM, and entropy values were − 0.146, 0.102, 0.098, and − 0.092, respectively, with P < 0.05.
Conclusions
Patients with ADD experience changes in the texture parameters of the LPM; among these, the entropy value of the LPM has high value in distinguishing ADDwoR from ADDwR, which can be used as an indicator to evaluate diseases that cause changes in the lateral pterygoid muscles. In addition, the degree of disc displacement is correlated to different degrees to the texture parameters. However, more research is needed to confirm the correlation between each numerical texture change and the corresponding pathological changes in the LMP.
Myocardial flow reserve in chronic kidney disease and renal transplantation: A cross-sectional study of ammonia PET
Authors: NAKAO RISAKO , Nagao Michinobu , Nakao Masashi , Yamamoto Atsushi , Ando Kiyoe , Sakai Akiko , Yamaguchi Junichi
Published: November 2024

Objective Renal transplantation (RT)’s effects on coronary artery and microvascular diseases is not yet elucidated. We aimed to quantify myocardial blood flow (MBF) using 13N-ammonia positron emission tomography (NH3-PET) and compare the results between RT recipients and patients with chronic kidney disease (CKD).Methods Adenosine-stress NH3-PET measurements of 29 RT recipients and 564 patients with CKD were assessed. Stress and rest MBF were calculated from the dynamic data of the initial 2 min after the ammonia injection. Myocardial flow reserve (MFR) was defined as stress MBF divided by rest MBF; MFR < 2.0 or stress MBF < 2.0 ml/g/min was considered a significant decrease.Results Stress MBF for RT recipients and patients with end-stage and mild-stage CKD was 2.03 ± 0.60, 1.72 ± 0.62, and 2.07 ± 0.61 ml/g/min, respectively; their MFRs were 2.00 ± 0.60, 1.68 ± 0.51, and 2.26 ± 0.69, respectively. Stress MBF and MFR were significantly greater in RT recipients than in patients with end-stage CKD (P < 0.01). The MFR was significantly greater in patients with mild-stage CKD than in RT recipients (p < 0.05); however, there was no significant difference in stress MBF. The proportion of patients with MFR ≥ 2.0 or stress MBF ≥ 2.0 ml/g/min was significantly higher in RT recipients than in patients with end-stage CKD (51.7% vs. 26.3%, and 58.6% vs. 26.3%, p < 0.01).Conclusion RT may improve MFR in patients with end-stage CKD by acting on adenosine vasodilation.
Development of New Affinity Material for Urease Purification: Synthesis and Characterization
Authors: Uygun Hilmiye Deniz Ertuğrul , Coşkun Elif Esen , Öztürk Simge , Demir Münire Nalan
Published: November 2024

Urease (urea amidohydrolase, E.C.3.5.1.5) is an enzyme that catalyzes the hydrolyzation of urea to form ammonium and carbon dioxide. This is an essential reaction in industrial and medical applications. Urease has a vital role in accelerating the hydrolysis of the urea in the agricultural gut, calculating the amount of urea in biological fluids, urine removal from artificial kidneys, and urea removal in wastewater and fruit juices. Purifying urease is also crucial for treating some diseases, such as gastrointestinal infection and hypertension. This research aimed at developing an environmentally friendly green biocomposite with high mechanical stability by suspension polymerization of chitosan (CTS), 2-hydroxyethyl methacrylate (HEMA), and N-methacryloyl- (L) -glutamic acid (MAGA) and to determine its optimum conditions for urease purification. The synthesized p (HEMA-MAGA) -CTS sorbent was investigated by FTIR, XPS, XRD, TGA, SEM, and particle size analysis. After the characterization, the parameters affecting the adsorption of urease, such as pH, sorbent amount, contact time, initial urease concentration, heat, and ionic strength, were optimized. In this study, equilibrium adsorption isotherms of urease on the synthesized affinity sorbent were examined and The Freundlich isotherm was found to provide a much better fit than the Langmuir and Dubinin-Radushkevich isotherms. The urease adsorbed on the p(HEMA-MAGA)-CTS affinity sorbent was desorbed in over 75% yield with 1.0 M NaSCN (pH 8.0) in 2 hours. The maximum adsorption capacity was found to be 9.47 mg mg-1 at pH 4.0 and 25°C. p(HEMA-MAGA)-CTS for urease purification was successfully developed.
Subtyping First-Episode Psychosis based on Longitudinal Symptom Trajectories Using Machine Learning
Authors: Benrimoh David , Liu Yanan , Jalali Sara , Joober Ridha , Lepage Martin , Iyer Srividya N. , Shah Jai
Published: November 2024

Clinical course after first episode psychosis (FEP) is heterogeneous. Subgrouping longitudinal symptom trajectories after FEP would be useful for developing personalized treatment approaches, and being able to predict these trajectories at baseline would facilitate individual-level treatment planning. We utilized k-means clustering to identify distinct clusters of 411 FEP patients based on longitudinal positive and negative symptom patterns. Ridge logistic regression was then used to identify predictors of cluster membership using baseline data. Three clusters were identified, demonstrating unique demographic, clinical and treatment response profiles. Cluster 1 exhibits lower positive and negative symptoms (LS), lower antipsychotic dose, and relatively higher affective psychosis; Cluster 2 shows lower positive symptoms, persistent negative symptoms (LPPN), and intermediate antipsychotic doses; Cluster 3 presents persistently high levels of both positive and negative symptoms (PPNS), as well as higher antipsychotic doses. We effectively predicted patients’ cluster membership (AUC of 0.74). The most important predictive features included contrasting trends of apathy, affective flattening, and anhedonia for the LS and LPPN clusters. Global hallucination severity, positive thought disorder and manic hostility predicted PPNS. These results help parse the heterogeneity of FEP trajectories and may facilitate the development of personalized treatment approaches tailored to cluster characteristics.
Effect of parecoxib alone versus parecoxib combined with nefopam hydrochloride on postoperative morphine consumption in major laparoscopic gynecologic surgery: a retrospective study
Authors: Pariyavatkul Nantakorn , Hengrasmee Pattaya , Chalermchockcharoenkit Amphan , Triyasunant Namtip , Boriboonhirunsarn Dittakarn , Phankingthongkum Siripreeya
Published: November 2024

Purpose
This study aimed to compare the analgesic efficacy of parecoxib alone versus parecoxib combined with nefopam hydrochloride in patients undergoing major laparoscopic gynecologic surgery at a university tertiary care medical center. The primary outcomes were the proportions of patients who needed morphine and total morphine consumption. The secondary outcomes were the maximum pain score and adverse drug effects.
Methods
This retrospective cohort study included 226 patients who underwent major laparoscopic gynecologic surgery between December 2019 and February 2022. The parecoxib group received 40 mg parecoxib intravenously at surgery initiation and 12 hours later. The parecoxib plus nefopam group received the same parecoxib regimen. Additionally, they received 20 mg nefopam hydrochloride intravenously over 1 hour concurrently with the first parecoxib dose, followed by 40 mg nefopam over the next 12 hours.
Results
The combination of parecoxib with nefopam significantly reduced both the proportion of patients necessitating morphine and the cumulative morphine consumption at 1, 6, 12, and 24 hours postoperatively (P < 0.001). The median maximum pain score at 1 hour postoperatively was also lower in the combination group. However, at 6, 12, and 24 hours postoperatively, the median maximum pain scores and adverse drug effects did not differ significantly between the two groups.
Conclusions
Adding nefopam to parecoxib demonstrated an opioid-sparing effect in major laparoscopic gynecologic surgery, reducing the proportion of patients requiring morphine, decreasing morphine consumption at multiple postoperative time points, and lowering early postoperative pain scores.
The Impact of Multidisciplinary Team Meetings on the Management of Metastatic Prostate Cancer in a Reference Center
Authors: Nascimento Lucas Antonio Pereira do , Junior Renato Meirelles Mariano da Costa , Machado Vinicius Ramos , Filho João Jorge Saab , Bavaresco Mário Henrique Bueno , Panhoca Renato , França Wagner Aparecido , Rios Luis Augusto Seabra , Pinheiro Gregório
Published: November 2024

Purpose: Prostate cancer (PC) is the second most common cancer in the male population. Considering its clinical-epidemiological profile, the different scenarios of presentation and the various treatment options, multidisciplinary meetings (MDM) are an inseparable part of therapeutic planning. Despite this, there is a lack of data proving their impact on the outcome of patients with prostate cancer.
Methods: Retrospective, single-center cohort evaluating the impact of the Tumor Board (TBD) on several variables related to the oncological outcome of patients with metastatic prostate cancer (MPC). Patients were divided into two periods: (1) 2018 - 2019, before TBD; and (2) 2021 - 2022, after TBD. Demographic, qualitative and quantitative characteristics were assessed.
Results: 139 patients were included, 72 in the 2018 - 2019 period and 67 in the 2020 - 2021 period. There was a significant reduction in the time taken to consult clinical oncology (p < 0.05) and to start treatment (p < 0.05). Systemic therapy started predominantly in the castration-sensitive setting (70.2% vs 14.3%; p = 0.000). The TBD promoted a higher quality of treatment, with a greater prescription of Docetaxel and new antiandrogens (95.7% vs 64.3%; p = 0.001) and zoledronic acid in the castration-resistant phase (92.5% vs 79.2%; p = 0.047). The TBD discussion optimized follow-up with dropout in only 7.5% of cases (p = 0.000).
Conclusion: TBD has a significant impact on the health care of patients with MPC and should be adopted as routine in services that provide this care.
Острова в Балтийском море в античной литературе от Гомера до Иордана
Authors: А.В. Подосинов
Published: November 2024

Статья посвящена анализу представлений античных авторов об островах в Балтийском море. Первый мифологический этап освоения Балтийского моря был связан с космологическими умозрительными теориями греков периода архаики, в которых Земля представлялась окруженной со всех сторон рекой-океаном. Именно во время океанических плаваний античных героев, в частности, Одиссея впервые описываются острова Северного Океана, которые еще имеют фантастический, сказочный характер и при этом оказываются вратами в иной мир (острова лестригонов, Кирки и киммерийцев). После плавания на север Европы греческого путешественника IV в. до н.э. Пифея из Массалии начинается настоящее знакомство с акваторией Балтийского моря, закончившееся открытием Скандинавии, правда, сначала как острова. В статье прослеживается освоение Балтики и ее островов вплоть до раннего cредневековья (Иордан).
Структура поселений и феномен инкастелламенто в поствизантийской Северо-Восточной Италии VIII–X веков
Authors: А.Б. Целунов
Published: November 2024

Настоящая статья ставит своей целью анализ письменных источников документального характера в контексте изучения характера и эволюции территориальной организации и структуры поселений в поствизантийской северо-восточной Италии, совпадавшей с границами бывшего Экзархата с центром в Равенне и длительное время находившейся под административным контролем влиятельной Равеннской архиепископии. На протяжении более чем трёх столетий после падения константинопольской власти историко-географическое единство региона определялось континуитетом в системе организации пространства и системы поселений, многое унаследовавшей от познеримской эпохи, и набиравшие силу процессы инкастелламенто, синхронно зафиксированные во многих регионах северной Италии, не привели, тем не менее, к реорганизации пространства в сторону формирования альтернативных социально-политических и экономических центров власти, имеющих достаточный потенциал к значительной аккумуляции населения.
Границы и административное деление Тверского уезда в XVI веке
Authors: С.С. Кутаков , Ю.В. Степанова
Published: November 2024

Статья посвящена территориально-админис-тративному устройству Тверского уезда XVI в. Источниками исследования являются писцовые описания и актовый материал XVI в., картографические материалы XVIII–XX веков. С использованием ГИС-технологий произведена локализация населенных пунктов Тверского уезда. Уточнены границы уезда. Изучено волостное деление уезда. Изучение территории Тверского уезда Московского государства важно для понимания особенностей формирования границ и структуры предшествовавшего уезду Тверского княжества — одного из важнейших государственных образований средневековой Руси.
МЕСТА ПАМЯТИ ИЛИ ПАМЯТЬ МЕСТА?ДВЕ БИТВЫ АЛЕКСАНДРА НЕВСКОГОВ ИСТОРИЧЕСКОЙ ПАМЯТИ
Authors:  А. Филюшкин
Published: November 2024

Статья посвящена изучению особенностей мемориализации двух знаменитых битв князя Александра Невского – Невской битвы 1240 г. и Ледового побоища 1242 г. Битвы являются культовыми в русской истории, но сами места сражений долгое время были в забвении, а место Ледового побоища до сих пор установлено весьма приблизительно. Данный парадокс необычайно интересен для понимания механизма формирования национальной исторической памяти, ее обращения к средневековым образам. Получается, что нарративы, учебники, картины, кинематограф играют куда большую роль, чем физическое существование объекта памяти, «память места». История сражения в интеллектуальном и культурном пространстве ХIХ–ХХI вв. для нации гораздо реалистичнее, чем подлинная средневековая история сражения, которая реконструируется с трудом. Превращение этих событий в символы национальной памяти, «мобилизация средневековья» для идеологических нужд – целиком явление нового времени. В средневековье память о них была связана большей частью со святыми – участниками сражений, проявлением в истории этих сражений Божьей воли или династическими предками правящего царского рода.

Two famous battles of Alexander Nevsky were the Battle of the Neva in 1240 and the Battle on the Ice in 1242. They have a cult status in Russian history. But the battlefields had long been forgotten, and the place of Battle on the Ice is still unknown. There is a certain paradox: the memory of battles for a long time was in books, ecclesiastical texts. It was verbal, it had its visualization in the works of art, etc. But the battlefields themselves as a memory object are less important than the virtual veneration. This paradox is extremely interesting for understanding of the mechanism of formation of national historical memory. It turns out that the physical existence of the memory of the object plays a minor role, even for such seemingly obvious and important facilities like Battle of the Neva or the Battle of the Ice. The narratives, books, paintings, movies play a far greater role than the "memory space". It may not be monuments can be elsewhere. The story of the battle that has existed in the intellectual and cultural space of modern times, in the 19th and 21th centuries is much more rea for the nation than a genuine medieval history of the battle. The conversion of these events in the national memory of the characters, "the mobilization of the Middle Ages" for ideological needs is a wholly modern phenomenon.
475 ШАГОВ В ДРУГОЙ МИР, ИЛИ ИЗОБРАЖЕНИЕИНОСТРАННОГО ПРЕДПРИНИМАТЕЛЯВ ПРОИЗВЕДЕНИЯХ Н. С. ЛЕСКОВА
Authors:  А.  Келлер
Published: November 2024

С помощью литературных произведений, которые интегрируют в коммуникативные поля читающих и мыслящих людей из разных сословий, можно «измерить» градус «общественного мнения» и даже «накал страстей» вокруг темы иностранцев в России и привносимых ими инноваций в технике, одежде, культурных практиках. Произведения Н.С. Лескова предоставляют богатый материал для исследования отношения к иностранцам и иностранным предпринимателям в России XIX в. В этих произведениях видно неоднозначное и противоречивое отношение автора к данной проблематике, охватывающей темы межкультурной коммуникации и адаптации новых культурных и социальных практик.

Literary works that integrate intellectuals of various social strata into communicative efields help measure “public opinion” and even “passions” that surrounded the topic of foreigners in Russia, and innovations in technology, dress style and cultural practices introduced by them.. The oeuvre of N.S. Leskov offer us rich material for research into the subject of foreign entrepreneurs in Russia in the second half of the 19th century. Stories such as 'Levsha', 'The Islanders', 'Iron Will', and many others make clear the multi-sided and contradictory relationship which the author had with themes of intercultural communication and adaptation to new cultural and social practices.
АМЕРИКАНСКИЙ ТЕАТР МЕНЕСТРЕЛЬ-ШОУ В XIX в. ЖИЗНЬ, ХУДОЖЕСТВЕННАЯ РЕАЛЬНОСТЬ, ПАМЯТЬ
Authors:  Г.  Прокопенков
Published: November 2024

Статья посвящена менестрель-шоу – форме народного театра, популярной в США XIX в., и направлена на выявление роли художественной реальности в конструировании реальности социальной (идентификационные модели, перцепции, память о прошлом). Автор исходит из того, что, взяв группу функционально однородных текстов, можно рассмотреть ее как один текст и составить описание языка американских менестрель-шоу на различных текстуальных уровнях, уделяя особое внимание повествовательным, идеологическим и миро-структурам. Проведенное исследование позволяет: 1) определить коммуникативные стратегии и тактики в становлении идентификационных моделей США; 2) рассмотреть возникновение долгосрочных расовых стереотипов восприятия афроамериканцев; 3) объяснить, как изменение в восприятии художественной реальности формирует мифологическое мышление и одновременно активизирует историческую память о Юге США.

The article is devoted to the minstrel show – a popular form of folk theatre in the United States of America in XIX century. The study is undertaken for the first time in domestic American studies and it aims to define the role of the artistic reality in constructing the social reality (identity models, perceptions, historical memory). The author proceeds from the assumption that a group of functionally homogeneous texts can be considered as a single text. This approach gives a description of the American minstrelsy language on various textual levels. In this case the special attention is paid to the narrative, ideological and world structures. This study allows to: 1) define the communicative strategies and tactics in developing of the US identity models; 2) consider the origin of the long-term racial stereotypes of African Americans; 3) explain how a change in the perception of the artistic reality forms the mythological thinking and at the same time activates the historical memory about the American South.
“ГРЕЧЕСКИЙ ВЗГЛЯД”КАК МАРКЕР ИДЕНТИЧНОСТНОГО КОНФЛИКТА?Перечитывая сочинение Томаса Уолсингема “Ditis ditatus”
Authors:  А.  Маслов
Published: November 2024

Характерными чертами «типично средневековых» представлений о гибели Трои нередко считается их зависимость от рассказов псевдо-очевидцев – Дарета Фригийского и Диктиса Критского (их «правдивые записи» противопоставлялись «лживым» сочинениям Гомера и иных древних поэтов), а также явная симпатия западных писателей к троянскому лагерю. Однако в ряде случаев данные оппозиции не наделялись принципиальным значением, и доминантой повествования оказывался синтез самых разных по происхождению известий о легендарном конфликте древности. Наиболее четко подобная «всеядность» проявляется в период XIV–XV вв., по мере существенной диверсификации корпуса троянских сказаний, усложнения соответствующей политической мифологии и усиления интереса к языческим верованиям как неотъемлемому элементу античной традиции. Обращаясь к произведению Томаса Уолсингема “Ditis ditatus”, автор акцентирует внимание на тех аспектах, которые прямо соотносятся с обозначенным синтетическим прочтением легендарного материала и техниками согласования «исторической» и «поэтической» репрезентации троянского прошлого в контексте позднесредневековой культуры.

It is dependence on the narratives of the so-called “real witnesses” (‘Dares the Phrygian’ and ‘Dictys of Crete’), not the “poets” (like Homer), and also deep sympathy toward the Trojans that usually seem to scholars the most typical feature of the medieval Troy stories. However there were some cultural contexts and situations when the oppositions had no such a cruel significance and the synthesis of the legend’s different versions became more important for narrators. Analyzing Thomas Walsingham’s Ditis ditatus the author emphasizes in it those narrative details, which could be related to this “synthetic” approach to representations of the ancient past and to a kind of concordance between “historical” and “poetic” views on the matter of Troy during the Late Medieval period.
«РУССКАЯ РЕВОЛЮЦИЯ И ОБРАЗОВАНИЕ РЕСПУБЛИКИАРМЕНИЯ НА КАВКАЗЕ (1917–1918 гг.)» А. И. ХАТИСОВА
Authors: К.Р. Амбарцумян
Published: November 2024

Публикация фрагмента воспоминаний Александра Ивановича Хатисова (1874–1945), члена правительства независимой Республики Армения, с 1920 г. жившего в эмиграции во Франции. Рукопись была им подготовлена в 1924 г. для «Архива русской революции», издаваемого И.В. Гессеном в Берлине, но в него не вошла.

A publication of a fragment from the memoirs by Alexandr Ivanovich Khatisov (1874–1945), a member of the government of the independent Armenian Republic, who lived in exile in France from 1920. He prepared the manuscript in 1924 for the “Archive of the Russian Revolution” published by I.V. Gesen in Berlin, but it was not included into this collection.
ИСТОРИЯ ИСТОРИЧЕСКОЙ НАУКИ И ИСТОЧНИКОВЕДЕНИЕ О НОВОМ УЧЕБНИКЕ ПО ИСТОЧНИКОВЕДЕНИЮ
Authors:  Т.  Булыгина ,  М.  Колесникова
Published: November 2024

Рец. на книгу: Источниковедение: учеб. пособие / И.Н. Данилевский, Д.А. Добровольский, Р.Б. Казаков и др.; отв. ред. М.Ф. Румянцева. М.: Изд. Дом Высшей школы экономики, 2015. – 685 с.
ПРОБЛЕМА ОСМЫСЛЕНИЯ ВАРВАРСТВА В СОВРЕМЕННОЙ РЕАЛЬНОСТИ
Authors: И.Г. Яковенко
Published: November 2024

В статье на российском материале исследуется природа латентного варварства и перспективы развития этого феномена. Автор рассматривает латентного варвара как паллиативный социокультурный тип, возникающий в ходе сложных и болезненных процессов вписания архаика в культуру зрелой цивилизации. Процесс этот разворачивается в ходе межгенерационной преемственности. При этом каждое последующее поколение в большей мере вписано в город и культуру большого общества.

The article on the Russian material explores the nature of latent barbarism and the prospects for the development of this phenomenon. The author views the latent barbarian as a palliative sociocultural type arising from the complex and painful processes of fitting the archaic into the culture of mature civilization. This process unfolds during intergenerational continuity. At the same time, each subsequent generation is more integrated into the city and culture of a large society.
ЛАТЕНТНАЯ ФОРМА ЗАЛОЖНИЧЕСТВА В ГЕРМАНСКИХ КОРОЛЕВСТВАХ РАННЕГО СРЕДНЕВЕКОВЬЯ
Authors: А.А. САЗОНОВА
Published: November 2024

В статье анализируется исторический феномен латентного заложничества в брачной сфере, связанный с комплексом архаических институтов традиционной древнегерманской культуры — кровной местью и матримониальным свойством, межгентильными отношениями и выплатой вергельда. Для раскрытия темы в хронологических рамках V–VIII вв. выделяются два цивилизационных полюса — имперская стратегия брачной политики и основанный на многовековом опыте межродового союзничества и вражды германский институт брачного заложничества. Их историческое столкновение рассматривается на примерах внутрисемейной политики остгота Теодориха Великого, инверсированной меровингской модели у франков и эталонного воплощения в англосакских королевствах VII в. Были выявлены существенные различия в этнических культурах восточных и западных германцев (готов, вандалов, лангобардов, бургундов, франков и англосаксов). Делается итоговый вывод о выраженной динамике в сторону угасания и политической формализация для живой древнегерманской традиции за раннесредневековый период, закончившийся брачным казусом между Карлом Великим и англосакским королем Оффой.

The article analyzes the historical phenomenon of latent hostage in the marital sphere, associated with a complex of archaic institutions of traditional Old Germanic culture — blood feud and matrimonial relationship, intertribal contacts and payment of wergild. Two civilizational poles are distinguished to disclose this topic in the chronological limits of the 5-8th centuries: the imperial strategy of marriage policy and the Germanic institute of marriage hostage based on experience of alliance and hostility. Their historical clash is considered on the examples of the family policy of the Ostrogoth Theodoric the Great, the inverted Merovingian model of the Franks and the perfect realization in the Anglo-Saxon kingdoms in the 7th century. Significant differences were revealed in the ethnic cultures of the East and West Germanic peoples (Goths, Vandals, Lombards, Burgundians, Franks and Anglo-Saxons). The final conclusion is made about the attenuation dynamic and political formalization for a living Old Germanic tradition for the early medieval period, ending with a marital incident between Charlemagne and the Anglo-Saxon king Offa.
К ВОПРОСУ О СПЕЦИАЛЬНОМ ЯЗЫКЕ ЛАТЕНТНОГО ВАРВАРСТВА НА ПРИМЕРЕ ЭМБЛЕМ НАЦИОНАЛИСТИЧЕСКИХ ОРГАНИЗАЦИЙ В РОССИИ 1990‑2019 ГОДОВ
Authors: К.А. ЕЛОХИН
Published: November 2024

Статья посвящена изучению эмблем современных русских националистических организаций, в том числе возникших во времена СССР. Автор рассматривает основные тенденции в их эмблематике. Часть идеологов националистических организаций создавала эмблематику своих организаций с нуля в форме модных политических и коммерческих логотипов. Другие праворадикальные организации обратились к псевдорунической неонацистской эмблематике, основанной на символике III Рейха. А иные — к псевдославянской эмблематике, используя в качестве эмблем фрагментированные обереги. Некоторые националистические организации доходят до абсурда, сочетая советскую и национал-социалистическую символику. Ряд националистических организаций обратились к неоязычеству, формируя новую веру. В статье предложены пути противодействия националистической пропаганде.

The article is devoted to the study of emblems of modern Russian nationalist organizations, including those that arose during the Soviet era. The author considers the main trends in their emblems. Some ideologists of nationalist organizations created the emblems of their organizations from zero in the form of fashionable political and commercial logos. Other right-wing organizations turned to pseudo-runic neo-Nazi emblems based on the symbols of the Third Reich. Still others go to the pseudo-Slavonic emblems, using for this fragmented amulets. Some nationalist organizations reach the point of absurdity, combining Soviet and National Socialist symbols. A number of nationalist organizations turned to neopaganism, forming a new faith. The article suggests ways to counter nationalist propaganda.
КОВАРСТВО И ИНТРИГИ В РИМСКОЙ АРМИИ
Authors: И.Е. ЕРМОЛОВА
Published: November 2024

Коварство и вероломство античные писатели считали непременными качествами варваров. Но эти же приемы столетиями применялись и в римском общества. Примеров тому можно привести огромное множество. Один из эпизодов истории IV в. представляется наиболее интересным, так как показывает, насколько субъективной может быть позиция автора по отношению к очень похожим по своей сути поступкам в зависимости от того, кто их совершает, и насколько различным может быть освещение событий, если в этом проявляется личная заинтересованность писателя.

The ancient writers considered that the perfidy and the insidiousness were the compulsory barbarian’s qualities. But these methods were used and in Roman society for many centuries. There are many examples of it. One episode of the Roman history of the IV century is the most interesting, because it shows, what subjective the historian’s position can be to the very like acts in dependence of theirs authors; and how different can be events’ illumination, if the writer’s personal interest is displayed in it.