bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphologische und funktionelle Folgen nach COVID-19-Pneumonie
Authors: Milos Ruxandra-Iulia , Kifjak Daria , Heidinger Benedikt H. , Prayer Florian , Beer Lucian , Röhrich Sebastian , Wassipaul Christian , Gompelmann Daniela , Prosch Helmut
Published: September 2021

Hintergrund

Nach einer Coronavirus-Krankheit-2019 (COVID-19) berichtet ein Teil der Patienten über länger andauernde oder sich verschlechternde Symptome und Beeinträchtigungen. Diese anhaltenden Symptome werden mit dem Begriff „Long-COVID“-Syndrom zusammengefasst. Sie können mit radiologischen Veränderungen in der Computertomographie (CT) und einer Verschlechterung der Lungenfunktion einhergehen.

Ziel der Arbeit

Die Rolle der langfristigen Verlaufskontrollen von COVID-19-Patienten wird erörtert, um festzustellen, welche Patienten davon profitieren können.

Material und Methoden

In diesem Artikel werden die aktuellen Ergebnisse der klinischen, radiologischen und lungenfunktionellen Nachsorgenuntersuchungen nach COVID-19-Pneumonie präsentiert.

Ergebnisse

Chronische Müdigkeit und Dyspnoe sind die häufigsten anhaltenden Symptome nach COVID-19. Außerdem zeigen viele dieser Patienten eine Beeinträchtigung der körperlichen Leistungsfähigkeit. In der CT sind Milchglasareale und strangförmige Verdichtungen die häufigsten residualen Veränderungen nach einer COVID-19-Pneumonie, die histologisch einer organisierenden Pneumonie entsprechen. Ein Teil der Patienten kann nach einer schweren COVID-19-Pneumonie im Verlauf fibroseähnliche Veränderungen aufweisen. Patienten mit einem vormals schwereren Verlauf können ein restriktives Syndrom mit niedriger Kohlenmonoxid-Diffusionskapazität (DLCO) und Gesamt-Lungenkapazität (TLC) zeigen. Im längerfristigen Verlauf zeigen die meisten Patienten eine deutliche und kontinuierliche Verbesserung aller Symptome sowie einen Rückgang der radiologisch-morphologischen und funktionellen Veränderungen.

Diskussion

Patienten mit persistierenden Symptomen nach COVID-19 sollten in spezialisierten Post-COVID-19-Ambulanzen multidisziplinär abgeklärt und behandelt werden.
Akute und chronische kardiale Beteiligung bei COVID-19
Authors: Beitzke Dietrich
Published: September 2021

Hintergrund

Neben pulmonalen Manifestationen ist eine COVID-19-Infektion (Coronavirus-Krankheit 2019) häufig mit kardiovaskulären Komplikationen bzw. einer kardiovaskulären Beteiligung assoziiert. Das Herz kann im Rahmen einer Infektion sowohl direkt im Rahmen einer Myokarditis oder Perikarditis und auch im Rahmen von Hypoxie, Fieber, Volumenbelastungen oder thrombembolischer Komplikationen involviert werden. Bestehende kardiovaskuläre Grunderkrankungen haben zudem einen maßgeblichen Einfluss auf die Prognose von COVID-19-infizierten Patienten.

Methode

Diese Übersichtsarbeit basiert auf einer umfassenden Literaturrecherche in der PubMed-Datenbank zu kardialen Beteiligungen und kardialen Komplikationen einer COVID-19-Infektion sowie deren Abgleich mit eigenen Erfahrungen.

Ergebnisse und Schlussfolgerung

Je nach Schweregrad der Infektion werden kardiale Beteiligungen im Rahmen einer COVID-19-Infektion mit bis zu 50 % durchaus häufig beobachtet. Neben der Echokardiographie als Untersuchungsmethode der ersten Wahl stellen die kardiale Magnetresonanztomographie (MRT) zur Beurteilung der myokardialen Struktur und die kardiale Computertomographie (CT) zur Beurteilung der Koronararterien bzw. zum Ausschluss eines intrakardialen Thrombus bedeutende Untersuchungsmodalitäten dar. Die wichtigsten kardialen Manifestationen einer COVID-19-Infektion sind entzündliche und ischämische Pathologien. Deren bildgebende Diagnostik spielt sowohl im akuten als auch im postinfektiösen Stadium eine bedeutende Rolle.
Enhancement of the wettability of graphite-based lithium-ion battery anodes by selective laser surface modification using low energy nanosecond pulses
Authors: Kleefoot Max-Jonathan , Enderle Sebastian , Sandherr Jens , Bolsinger Marius , Maischik Thomas , Simon Nadine , Martan Jiří , Ruck Simon , Knoblauch Volker , Riegel Harald
Published: September 2021

The electrolyte filling process of battery cells is one of the time-critical bottlenecks in cell production. Wetting is of particular importance here, since only completely wetted electrode sections are working. In order to accelerate and facilitate this process, the authors of this study developed a method to significantly increase the wettability of graphite-based anodes by a laser surface modification using low energy nanosecond laser pulses. The anode surface microstructure was evaluated by means of white-light interferometry and scanning electron microscopy. The assessment of wettability was done by drop test and capillary rise test of the liquid electrolyte. The results show that there is a predominantly selective ablation process for laser energy inputs below 2 J/m by which the graphite active material remains unaffected and the binder material is decomposed. The observed increase in surface roughness correlates with the increasing wettability. Investigations using Raman spectroscopy showed that laser treatment leads to a damage on the crystalline structure of the graphite particle surface. However, treating an entire anode including 6 wt% binder and conductive carbon black has shown that the overall amorphous content of the anodes surface can be reduced by 32% through treating the surface with a laser energy of 1.29 J/m. Up to that point, which is the resulting parameter range for the selective process, it is possible to ablate the amorphous binder and carbon black phase coevally exposing graphite particles while keeping their crystalline structure. Exceeding that range, ablation of the whole anode composite dominates and amorphization of the graphite surface occurs. The electrode’s capacity was tested on half-cells in coin cell format. For the whole laser parameter range investigated, the anodes capacity matches the mass loss caused by laser ablation. No additional capacity loss was observed due to amorphization of the exterior graphite particle’s surface.
Linking Macroinvertebrates and Physicochemical Parameters for Water Quality Assessment in the Lower Basin of the Volta River in Ghana
Authors: Onwona Kwakye Michael , Peng Feng-Jiao , Hogarh Jonathan N. , Van den Brink Paul J.
Published: September 2021

The health of the lower basin of the Volta River in Ghana was evaluated in January–February and May–June 2016 using physicochemical parameters and benthic macroinvertebrates sampled at 10 locations. Selected environmental variables were compared to accepted environmental water quality standard values where applicable. Principal component analysis (PCA) and redundancy analysis (RDA) were used to analyse the association between the benthic macroinvertebrates distribution and physicochemical variables. Pesticide concentrations were generally below the limit of detection 0.01 and 0.005 µg/L for organophosphate/synthetic pyrethroid and organochlorines respectively. Nutrient levels were also generally low; however, significant differences existed between the values of physicochemical parameters at the different sampling sites and seasons (Monte Carlo permutation test; p = 0.002), as well as between the abundance of macroinvertebrates at the different sites and seasons (p = 0.002). The environmental variables dissolved oxygen (DO), phosphate, pH, substratum (p < 0.05), turbidity, conductivity, total dissolved solids, total solids and nitrate (0.05 < p < 0.10) significantly explained the variation in macroinvertebrate composition between sampling stations in the Volta River. Polypedilum fuscipenne, was positively correlated with turbidity and DO concentrations; Physa sp., Centroptilum sp., Centroptiloides sp., Phaon iridipennis and juvenile fish were positively correlated with nitrate concentration and pH and negatively correlated with turbidity and DO. Polluted sites were dominated by the snail Lymnaea glabra. This demonstrates that physicochemical parameters and macroinvertebrates could be applied to describe the water quality and improve the biomonitoring for water resources management and the environmental protection in the Lower Volta River.
Mouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan
Authors: Mizuno-Iijima Saori , Nakashiba Toshiaki , Ayabe Shinya , Nakata Hatsumi , Ike Fumio , Hiraiwa Noriko , Mochida Keiji , Ogura Atsuo , Masuya Hiroshi , Kawamoto Shoko , Tamura Masaru , Obata Yuichi , Shiroishi Toshihiko , Yoshiki Atsushi
Published: September 2021

The RIKEN BioResource Research Center (BRC) was established in 2001 as a comprehensive biological resource center in Japan. The Experimental Animal Division, one of the BRC infrastructure divisions, has been designated as the core facility for mouse resources within the National BioResource Project (NBRP) by the Japanese government since FY2002. Our activities regarding the collection, preservation, quality control, and distribution of mouse resources have been supported by the research community, including evaluations and guidance on advancing social and research needs, as well as the operations and future direction of the BRC. Expenditure for collection, preservation, and quality-control operations of the BRC, as a national core facility, has been funded by the government, while distribution has been separately funded by users’ reimbursement fees. We have collected over 9000 strains created mainly by Japanese scientists including Nobel laureates and researchers in cutting-edge fields and distributed mice to 7000 scientists with 1500 organizations in Japan and globally. Our users have published 1000 outstanding papers and a few dozen patents. The collected mouse resources are accessible via the RIKEN BRC website, with a revised version of the searchable online catalog. In addition, to enhance the visibility of useful strains, we have launched web corners designated as the “Mouse of the Month” and “Today’s Tool and Model.” Only high-demand strains are maintained in live colonies, while other strains are cryopreserved as embryos or sperm to achieve cost-effective management. Since 2007, the RIKEN BRC has built up a back-up facility in the RIKEN Harima branch to protect the deposited strains from disasters. Our mice have been distributed with high quality through the application of strict microbial and genetic quality control programs that cover a globally accepted pathogens list and mutated alleles generated by various methods. Added value features, such as information about users’ publications, standardized phenotyping data, and genome sequences of the collected strains, are important to facilitate the use of our resources. We have added and disseminated such information in collaboration with the NBRP Information Center and the NBRP Genome Information Upgrading Program. The RIKEN BRC has participated in international mouse resource networks such as the International Mouse Strain Resource, International Mouse Phenotyping Consortium, and Asian Mouse Mutagenesis and Resource Association to facilitate the worldwide use of high-quality mouse resources, and as a consequence it contributes to reproducible life science studies and innovation around the globe.
Short-, long-, and very long-term results of secondary anterior sphincteroplasty in 20 patients with obstetric injury
Authors: Haug Helene Marie , Carlsen Erik , Johannessen Hans-Olaf , Johnson Egil
Published: September 2021

Purpose

More long-term follow-up studies beyond 10 years after secondary sphincteroplasty for obstetric damage are warranted. This prospective study aimed to compare reported data on incontinence and satisfaction in a cohort of such patients examined at short-, long-, and very long-term follow-up.

Methods

Twenty out of 33 obstetric patients (61%) operated with secondary anterior overlapping sphincteroplasty during February 1996 to April 2004 were evaluated preoperatively and at short-, long-, and very long-term follow-up. Anal incontinence was scored by a combination of Wexner’s and St. Mark’s incontinence scores. The patients also reported degree of treatment satisfaction.

Results

Twenty patients were examined preoperatively and after a median (range) of 5 (2–62), 102 (64–162), and 220 (183–278) months. Corresponding incontinence scores were 11.5 (5–18), 5.5 (1–17) (p < 0.01), 10.0 (0–18) (p > 0.05), and 12.0. (1–18) (p > 0.05). With increasing follow-up times, patients reporting a better outcome were 75%, 65%, and 45%. At very long-term follow-up patients, reports were more dismal than expected in those also reporting improved incontinence cores. Incontinence scores did not improve in patients with neuropathy (n = 5) or patients (n = 5) with more than 10 years of symptoms.

Conclusion

Initial improvement of anal incontinence attenuated with time, in particular from short- to long-term follow-up. Patients with neuropathy experienced no improvement of incontinence. Beyond stoma formation, in compliant patients, one should consider other treatment options like sacral nerve stimulation and neosphincter formation.
Rainfall regime trends at annual and monthly scales in Catalonia (NE Spain) and indications of CO2 emissions effects
Authors: Lana Xavier , Casas-Castillo M. Carmen , Rodríguez-Solà Raül , Serra Carina , Martínez M. Dolors , Kirchner Ricard
Published: September 2021

The pluviometric regime in the Western Mediterranean and concretely in Catalonia (NE Spain) is characterised by irregular amounts at monthly and annual scales, sometimes with copious short episodes causing floods and, conversely, sometimes with long dry spells exceeding 1 month length, depending on the chosen threshold level to define the dry episode. Taking advantage of a dense network of rain gauges, most of them with records length of 50–60 years and some others exceeding 85 years, the evolution of these monthly and annual amounts is quantified by means of their time trends, statistical significance and several irregularity parameters. In agreement with the evolution of the CO2 emissions into the atmosphere and the increasing concentration, in parts per million (ppm), of this greenhouse gas, different time trends at annual scale have been detected up to approximately years 1960–1970 in comparison with the interval 1960–1970 to nowadays. Consequently, besides the greenhouse effects on the temperature regime, the influence on the pluviometric regime could not be negligible.

Graphical abstract
Identification of rockfall source areas using the seed cell concept and bivariate susceptibility modelling
Authors: Toševski Aleksandar , Pollak Davor , Perković Dario
Published: September 2021

The objective of this research was to prepare a rockfall susceptibility map. Explorations were conducted in the Dubračina River basin (Croatia). The input data included a geological map, an orthophoto and a 1-m digital terrain model (DTM). After a talus inventory was prepared, the seed cell concept was applied to define the rockfall source areas. The contributing factors (predictors) of rockfalls were evaluated by the chi-squared test. The analysis confirmed the following predictors: CORINE land cover, lithology, slope, aspect, distance from a spring, distance from a road, distance from a fault, distance from a stream, and distance from the rock-soil geological boundary. A matrix pairwise comparison of the predictor ratings was used to define the most significant contributing factors. The predictors that affected the susceptibility map in the share of 86.3% were the slope (61.6%), lithology (13.4%), CORINE land cover (6.2%), and distance from the rock-soil geological boundary (5.1%). Two susceptibility maps were prepared: one using all nine contributing factors and another using the four most significant factors. The analysis showed that both maps were good, with the same areas under the receiver operating characteristic (ROC) curves. The map prepared with only four contributing factors can be considered a better map due to its more precise spatial definition of critical areas. It can be concluded that geological map, 1-m DTM and orthophoto provide enough data to prepare reliable rockfall susceptibility map. The application of the bivariate statistical zonation method called the “frequency ratio method” was proven to be successful. This research demonstrates that the application of the seed cell concept can be useful to speed up the process of rockfall source area detections in large research regions.
Genetic testing in women with early-onset breast cancer: a Traceback pilot study
Authors: Augustinsson Annelie , Nilsson Martin P. , Ellberg Carolina , Kristoffersson Ulf , Olsson Håkan , Ehrencrona Hans
Published: September 2021

Purpose

In Sweden, a Traceback approach, i.e., a retrospective genetic outreach activity, among cancer patients is not normally used in clinical practice. In this pilot study, we wanted to evaluate a Traceback strategy for possible future clinical implementation and investigate why not all women with early-onset breast cancer underwent genetic testing when they were first diagnosed.

Methods

Out of all women (n = 409) diagnosed with breast cancer at ≤ 35 years in Southern Sweden between 2000 and 2017, 63 had not previously been tested. These women were offered an analysis of the genes BRCA1, BRCA2, PALB2, CHEK2, and ATM through a standardized letter. Subsequently, women with normal test results were informed through a letter and carriers of pathogenic variants were contacted through a telephone call and offered in-person genetic counseling. All tested women were asked to complete a follow-up questionnaire regarding previously not having attended genetic counseling and testing and their experiences of the current retrospective approach.

Results

Out of the invited women, 29 (46%) underwent genetic testing and 27 (43%) answered the questionnaire. Pathogenic variants were identified in BRCA1 (n = 2), CHEK2 (n = 1), and ATM (n = 1). The main reason for previously not having undergone genetic testing was not having received any information from their physicians. Most study participants were satisfied with both written pre- and post-test information.

Conclusion

The process with retrospective identification, written pre-test information, and genetic testing, followed by in-person counseling for carriers of pathogenic variants only, was well accepted. This has implications for future Traceback implementation programs.
Humour in Children’s and Young Adult Literature: The Work of Gilles Bachelet
Authors: Muela Bermejo Diana
Published: September 2021

The work of the French illustrator and writer Gilles Bachelet has been recognised through numerous awards, but he is not yet sufficiently well known in the critical community. In this article, the multilevel humour that constructs his work is studied, both from an iconic and a textual perspective, as well as the situational humour and the humour of characters that emerge through metafiction, self-referentiality and heteroreferentiality. For this purpose, the theories of humour in children’s literature and the classifications of types of humour offered by different researchers are used as a starting point, and a mixed model of analysis applicable to Bachelet’s work as a whole is proposed. In addition, the analysis of each of the picturebooks is based on the most recent studies on the components of the current picturebook, such as its narrative construction, type of reading, characteristics and organisation of text and image. In this way, the postmodern features of Gilles Bachelet's works, which make him a crossover author, are revealed.
Impact of Carbon Pricing on Low-Carbon Innovation and Deep Decarbonisation: Controversies and Path Forward
Authors: van den Bergh Jeroen , Savin Ivan
Published: September 2021

There is an ongoing discussion about the effectiveness of carbon pricing, with a strong division between optimists and pessimists. A recent review study by Lilliestam, Patt and Bersalli (2021) of the impact of carbon pricing on low-carbon innovation and deep carbonization concludes that there is no evidence for such an impact. We evaluate this study and identify various shortcomings of it, which together cast strong doubts on its main conclusion. Instead, we conclude, based on the studies reviewed by the authors and additional, overlooked literature, that carbon pricing has had a small but positive and significant effect on low-carbon innovation. Our evaluation provides lessons for undertaking a systematic and objective review of research on this topic. Since the main goal of carbon pricing is changing choices by firms and consumers that affect carbon emissions, we also point the reader towards recent evidence for the broader effectiveness of carbon pricing.
Linguistic Mistakes
Authors: Reiland Indrek
Published: September 2021

Ever since the publication of Kripke’s Wittgenstein on Rules and Private Language, there’s been a raging debate in philosophy of language over whether meaning and thought are, in some sense, normative. Most participants in the normativity wars seem to agree that some uses of meaningful expressions are semantically correct while disagreeing over whether this entails anything normative. But what is it to say that a use of an expression is semantically correct? On the so-called orthodox construal, it is to say that it doesn’t result in a factual mistake, that is, in saying or thinking something false. On an alternative construal it is instead to say that it doesn’t result in a distinctively linguistic mistake, that is, in misusing the expression. It is natural to think that these two construals of semantic correctness are simply about different things and not necessarily in competition with each other. However, this is not the common view. Instead, several philosophers who subscribe to the orthodox construal have argued that the alternative construal of correctness as use in accordance with meaning doesn’t make any sense, partly because there are no clear cases of linguistic mistakes (Whiting in Inquiry, 59:219–238, 2016, Wikforss in Philos Stud 102:203–226, 2001). In this paper I develop and defend the idea that there’s a distinctively linguistic notion of correctness as use in accordance with meaning and argue that there are clear cases of linguistic mistakes.
Cuticular Hydrocarbon Trails Released by Host Larvae Lose their Kairomonal Activity for Parasitoids by Solidification
Authors: Awater-Salendo Sarah , Voigt Dagmar , Hilker Monika , Fürstenau Benjamin
Published: September 2021

Successful host search by parasitic wasps is often mediated by host-associated chemical cues. The ectoparasitoid Holepyris sylvanidis is known to follow chemical trails released by host larvae of the confused flour beetle, Tribolium confusum, for short-range host location. Although the hexane-extractable trails consist of stable, long-chain cuticular hydrocarbons (CHCs) with low volatility, the kairomonal activity of a trail is lost two days after release. Here, we studied whether this loss of kairomonal activity is due to changes in the chemical trail composition induced by microbial activity. We chemically analyzed trails consisting of hexane extracts of T. confusum larvae after different time intervals past deposition under sterile and non-sterile conditions. GC-MS analyses revealed that the qualitative and quantitative pattern of the long-chain CHCs of larval trails did not significantly change over time, neither under non-sterile nor sterile conditions. Hence, our results show that the loss of kairomonal activity of host trails is not due to microbially induced changes of the CHC pattern of a trail. Interestingly, the kairomonal activity of trails consisting of host larval CHC extracts was recoverable after two days by applying hexane to them. After hexane evaporation, the parasitoids followed the reactivated host trails as they followed freshly laid ones. Cryo-scanning electron microscopy showed that the trails gradually formed filament-shaped microstructures within two days. This self-assemblage of CHCs was reversible by hexane application. Our study suggests that the long-chain CHCs of a host trail slowly undergo solidification by a self-assembling process, which reduces the accessibility of CHCs to the parasitoid’s receptors as such that the trail is no longer eliciting trail-following behavior.
Bare singulars and singularity in Turkish
Authors: Sağ Yağmur
Published: September 2021

This paper explores the semantics of bare singulars in Turkish, which are unmarked for number in form, as in English, but can behave like both singular and plural terms, unlike in English. While they behave like singular terms as case-marked arguments, they are interpreted number neutrally in non-case-marked argument positions, the existential copular construction, and the predicate position. Previous accounts (Bliss, in Calgary Papers in Linguistics 25:1–65, 2004; Bale et al. in Semantics and Linguistic Theory (SALT) 20:1–15, 2010; Görgülü, in: Semantics of nouns and the specification of number in Turkish, Ph.d. thesis, Simon Fraser University, 2012) propose that Turkish bare singulars denote number neutral sets and that morphologically plural marked nouns denote sets of pluralities only. This approach leads to a symmetric correlation of morphological and semantic (un)markedness. However, in this paper, I defend a strict singular view for bare singulars and show that Turkish actually patterns with English where this correlation is exhibited asymmetrically. I claim that bare singulars in Turkish denote atomic properties and that bare plurals have a number neutral semantics as standardly assumed for English. I argue that the apparent number neutrality of bare singulars in the three cases arises via singular kind reference, which I show to extend to the phenomenon calledpseudo-incorporationand a construction that I callkind specification. I argue that pseudo-incorporation occurs in non-case-marked argument positions following Öztürk (Case, referentiality, and phrase structure, Amsterdam, Benjamins, Publishing Company, 2005) and the existential copular construction, whereas kind specification is realized in the predicate position. The different behaviors of bare singulars in Turkish and English stem from the fact that singular kind reference is used more extensively in Turkish than in English. Furthermore, while there are well-known asymmetries between singular and plural kind reference cross-linguistically, Turkish manifests a more restricted distribution for bare plurals than English in the positions where pseudo-incorporation and kind specification are in evidence. I explain this as a blocking effect, specific to Turkish, by singular kind terms on plural kind terms.
Modulation of endothelium function by fatty acids
Authors: Mallick Rahul , Duttaroy Asim K.
Published: September 2021

The endothelium acts as the barrier that prevents circulating lipids such as lipoproteins and fatty acids into the arterial wall; it also regulates normal functioning in the circulatory system by balancing vasodilation and vasoconstriction, modulating the several responses and signals. Plasma lipids can interact with endothelium via different mechanisms and produce different phenotypes. Increased plasma-free fatty acids (FFAs) levels are associated with the pathogenesis of atherosclerosis and cardiovascular diseases (CVD). Because of the multi-dimensional roles of plasma FFAs in mediating endothelial dysfunction, increased FFA level is now considered an essential link in the onset of endothelial dysfunction in CVD. FFA-mediated endothelial dysfunction involves several mechanisms, including dysregulated production of nitric oxide and cytokines, metaflammation, oxidative stress, inflammation, activation of the renin-angiotensin system, and apoptosis. Therefore, modulation of FFA-mediated pathways involved in endothelial dysfunction may prevent the complications associated with CVD risk. This review presents details as to how endothelium is affected by FFAs involving several metabolic pathways.
Climate change and the different roles of physicians: a critical response to "A Planetary Health Pledge for Health Professionals in the Anthropocene"
Authors: Wiesing Urban
Published: September 2021

The article critically responds to "A Planetary Health Pledge for Health Professionals in the Anthropocene" which was published by Wabnitz et al. in The Lancet in November 2020. It focuses on the different roles and responsibilities of a physician. The pledge is criticised because it neglects the different roles, gives no answers in case of conflicting goals, and contains numerous inconsistencies. The relationship between the Planetary Health Pledge and the Declaration of Geneva is examined. It is argued that the Planetary Health Pledge should have supplemented the Declaration of Geneva instead of changing it.
Association of high adherence to vegetables and fruits dietary pattern with quality of life among Chinese women with early-stage breast cancer
Authors: Lei Yuan-Yuan , Ho Suzanne C. , Kwok Carol , Cheng Ashley , Cheung Ka Li , Lee Roselle , Mo Frankie K. F. , Yeo Winnie
Published: September 2021

Purpose

Dietary intake and patients’ quality of life (QoL) are important supportive care issues in breast cancer survivorship. This study aimed to identify dietary pattern before and after breast cancer diagnosis. In addition, the association between dietary patterns and QoL were cross-sectionally and longitudinally investigated.

Methods

A breast cancer cohort which included 1462 Chinese women were longitudinally interviewed at four time-points, namely baseline, 18-, 36-, and 60 months after diagnosis. At each follow-up, validated food frequency questionnaires (FFQ) were used to assess patients’ dietary intake, and factor analysis was used to derive dietary patterns. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) were used to measure QoL at each follow-up. This study included 1368, 1226, 1079 and 1095 patients with invasive disease who completed assessment at baseline, 18-, 36- and 60-month follow-up and had detailed data of dietary intake and QoL.

Results

Based on data obtained at 18-month follow-up, two major dietary patterns were identified: “grain and animal food pattern” and “vegetables and fruits pattern”. Similar dietary patterns were obtained at baseline, 36- and 60- month follow-up. Generalized Estimating Equations (GEE) were used to analyze the longitudinal associations between dietary patterns and QoL over the four follow-ups. High intake of grain and animal food was inversely associated with scores for role functioning (B = − 0.744; 95%CI − 0.147 to − 0.017), dyspnea (B = − 0.092; 95%CI − 0.092 to − 0.092) and constipation (B = − 1.355; 95%CI − 2.174 to − 0.536). Vegetables and fruits intake were positively associated with scores for global health status/QoL (B = 1.282; 95%CI 0.545–2.019), physical functioning (B = 0.545; 95%CI: 0.037–1.053), emotional functioning (B = 1.426; 95%CI 0.653–2.200) and cognitive functioning (B = 0.822; 95%CI 0.007–1.637), while inversely associated with scores for nausea and vomiting (B = − 0.382; 95%CI − 0.694 to − 0.071), dyspnea (B = − 0.570; 95%CI − 0.570 to − 0.570), insomnia (B = − 1.412; 95%CI − 2.647 to − 0.177), loss of appetite (B = − 0.722; 95%CI − 1.311 to − 0.132), constipation (B = − 2.028; 95%CI − 2.775 to − 1.281) and diarrhea (B = − 0.929; 95%CI − 1.481 to − 0.377).

Conclusion

This study suggested that high adherence to “grain and animal food pattern” or “vegetables and fruits pattern” was significantly associated with several aspects of QoL. For instance, vegetables and fruits pattern appears to have beneficial effect on global health status/QoL among Chinese breast cancer patients. Prospective follow-up data could further confirm whether a specific dietary pattern has impact on cancer outcomes.
Segmentation of Coronal Features to Understand the Solar EUV and UV Irradiance Variability III. Inclusion and Analysis of Bright Points
Authors: van der Zwaard Rens , Bergmann Matthias , Zender Joe , Kariyappa Rangaiah , Giono Gabriel , Damé Luc
Published: September 2021

The study of solar irradiance variability is of great importance in heliophysics, Earth’s climate, and space weather applications. These studies require careful identifying, tracking and monitoring of features in the solar photosphere, chromosphere, and corona. Do coronal bright points contribute to the solar irradiance or its variability as input to the Earth atmosphere? We studied the variability of solar irradiance for a period of 10 years (May 2010 – June 2020) using the Large Yield Radiometer (LYRA), the Sun Watcher using APS and image Processing (SWAP) on board PROBA2, and the Atmospheric Imaging Assembly (AIA), and applied a linear model between the segmented features identified in the EUV images and the solar irradiance measured by LYRA. Based on EUV images from AIA, a spatial possibilistic clustering algorithm (SPoCA) is applied to identify coronal holes (CHs), and a morphological feature detection algorithm is applied to identify active regions (ARs), coronal bright points (BPs), and the quiet Sun (QS). The resulting segmentation maps were then applied on SWAP images, images of all AIA wavelengths, and parameters such as the intensity, fractional area, and contribution of ARs/CHs/BPs/QS features were computed and compared with LYRA irradiance measurements as a proxy for ultraviolet irradiation incident to the Earth atmosphere. We modeled the relation between the solar disk features (ARs, CHs, BPs, and QS) applied to EUV images against the solar irradiance as measured by LYRA and the F10.7 radio flux. A straightforward linear model was used and corresponding coefficients computed using a Bayesian method, indicating a strong influence of active regions to the EUV irradiance as measured at Earth’s atmosphere. It is concluded that the long- and short-term fluctuations of the active regions drive the EUV signal as measured at Earth’s atmosphere. A significant contribution from the bright points to the LYRA irradiance could not be found.
Coordinated Multicast/Unicast Transmission on 5G: A Novel Approach for Linear Broadcasting
Authors: Jiménez-Soria David , Martín-Vega Francisco J. , Aguayo-Torres Mari Carmen
Published: September 2021

Linear broadcasting services, with a scheduled programming, constitute a paramount telecommunication service for today’s society. Although the existing technology is mature, current linear broadcast systems have serious limitations when providing service to moving users or users placed in areas with complex orography and poor signal quality. To overcome these limitations, 3GPP 5G standard has included a work item to support 5G multicast/broadcast services for future Release 17. This paper investigates the integration of point-to-point (unicast) communication with cellular multicast/broadcast on 5G technology to extend the current support of linear broadcasting services. This integration relies on the use mobile edge computing (MEC) at the 5G base station (gNB) to host a dynamic adaptive streaming over HTTP (DASH) server that is coordinated with the multicast transmission to complement the broadcast service. This approach join the reliability of point-to-point communications, with dedicated resources for each user, with the spectrum efficiency of multi-cast communications, where a set of users share common resources. The cooperation between those unicast and multicast schemes allows those users whose coverage is not good enough, to complete the linear broadcast flow through the point-to-point transmission via MEC. The benefits of such approach have been assessed with simulations in a realistic scenario that considers a vehicle moving across a sparsely populated region in southern Spain. Results reveals that throughput and bitrate playback (reproduction rate) are greatly improved when unicast/multicast integration is enabled since the number of stalling events is reduced significantly.
Design method and verification of a hybrid prosthetic mechanism with energy-damper clutchable device for transfemoral amputees
Authors: Song Majun , Guo Sheng , Oliveira Anderson S. , Wang Xiangyang , Qu Haibo
Published: September 2021

Transfemoral amputees (TAs) have difficulty in mobility during walking, such as restricted movement of lower extremity and body instability, yet few transfemoral prostheses have explored human-like multiple motion characteristics by simple structures to fit the kinesiology, biomechanics, and stability of human lower extremity. In this work, the configurations of transfemoral prosthetic mechanism are synthesized in terms of human lower-extremity kinesiology. A hybrid transfemoral prosthetic (HTP) mechanism with multigait functions is proposed to recover the gait functions of TAs. The kinematic and mechanical performances of the designed parallel mechanism are analyzed to verify their feasibility in transfemoral prosthetic mechanism. Inspired by motion—energy coupling relationship of the knee, a wearable energy-damper clutched device that can provide energy in knee stance flexion to facilitate the leg off from the ground and can impede the leg’s swing velocity for the next stance phase is proposed. Its co-operation with the springs in the prismatic pairs enables the prosthetic mechanism to have the energy recycling ability under the gait rhythm of the knee joint. Results demonstrate that the designed HTP mechanism can replace the motion functions of the knee and ankle to realize its multimode gait and effectively decrease the peak power of actuators from 94.74 to 137.05 W while maintaining a good mechanical adaptive stability.
Mussel biology: from the byssus to ecology and physiology, including microplastic ingestion and deep-sea adaptations
Authors: Inoue Koji , Onitsuka Yuri , Koito Tomoko
Published: September 2021

Mussels are a group of bivalves that includes the dominant species of shallow-sea, freshwater, and deep-sea chemosynthetic ecosystems. Mussels cling to various solid underwater surfaces using a proteinaceous thread, called the byssus, which is central to their ecology, physiology, and evolution. Mussels cluster using their byssi to form “mussel beds,” thereby increasing their biomass per unit of habitat area, and also creating habitats for other organisms. Clustered mussels actively filter feed to obtain nutrients, but also ingest pollutants and suspended particles; thus, mussels are good subjects for pollution analyses, especially for microplastic pollution. The byssus also facilitates invasiveness, allowing mussels to hitchhike on ships, and to utilize other man-made structures, including quay walls and power plant inlets, which are less attractive to native species. Physiologically, mussels have adapted to environmental stressors associated with a sessile lifestyle. Osmotic adaptation is especially important for life in intertidal zones, and taurine is a major component of that adaptation. Taurine accumulation systems have also been modified to adapt to sulfide-rich environments near deep-sea hydrothermal vents. The byssus may have also enabled access to vent environments, allowing mussels to attach to “evolutionary stepping stones” and also to vent chimneys.
In-Vitro Visualization of Thrombus Growth in Artificial Lungs Using Real-Time X-Ray Imaging: A Feasibility Study
Authors: Kaesler Andreas , Rudawski Freya Lilli , Zander Mark Oliver , Hesselmann Felix , Pinar Isaac , Schmitz-Rode Thomas , Arens Jutta , Steinseifer Ulrich , Clauser Johanna Charlotte
Published: September 2021

Purpose

Extracorporeal membrane oxygenation has gained increasing attention in the treatment of patients with acute and chronic cardiopulmonary and respiratory failure. However, clotting within the oxygenators or other components of the extracorporeal circuit remains a major complication that necessitates at least a device exchange and bears risks of adverse events for the patients. In order to better predict thrombus growth within oxygenators, we present an approach for in-vitro visualization of thrombus growth using real-time X-ray imaging.

Methods

An in-vitro test setup was developed using low-dose anticoagulated ovine blood and allowing for thrombus growth within 4 h. The setup was installed in a custom-made X-ray setup that uses phase-contrast for imaging, thus providing enhanced soft-tissue contrast, which improves the differentiation between blood and potential thrombus growth. During experimentation, blood samples were drawn for the analysis of blood count, activated partial thromboplastin time and activated clotting time. Additionally, pressure and flow data was monitored and a full 360° X-ray scan was performed every 15 min.

Results

Thrombus formation indicated by a pressure drop and changing blood parameters was monitored in all three test devices. Red and white thrombi (higher/lower attenuation, respectively) were successfully segmented in one set of X-ray images.

Conclusion

We showed the feasibility of a new in-vitro method for real-time thrombus growth visualization by means of phase contrast X-ray imaging. In addition, with more blood parameters that are clinically relevant, this approach might contribute to improved oxygenator exchange protocols in the clinical routine.
Regulations Matter: Epistemic Monopoly, Domination, Patents, and the Public Interest
Authors: Meghani Zahra
Published: September 2021

This paper argues that regulatory agencies have a responsibility to further the public interest when they determine the conditions under which new technological products may be commercialized. As a case study, this paper analyzes the US 9th Circuit Court’s ruling on the efforts of the US Environmental Protection Agency (EPA) to regulate an herbicide meant for use with seed that are genetically modified to be tolerant of the chemical. Using that case, it is argued that when regulatory agencies evaluate new technological products, they have an obligation to draw on data, analyses, and evaluations from a variety of credible epistemic sources, and not rely solely or even primarily on the technology developer. Otherwise, they create conditions for their own domination and that of the polity by the technology developer. Moreover, in the interest of advancing the public interest, regulatory agencies must evaluate new technologies in a substantively and procedurally unbiased manner.
Rehabilitation and renovation of cocoa (Theobroma cacao L.) agroforestry systems. A review
Authors: Somarriba Eduardo , Peguero Felipe , Cerda Rolando , Orozco-Aguilar Luis , López-Sampson Arlene , Leandro-Muñoz Mariela E. , Jagoret Patrick , Sinclair Fergus L.
Published: September 2021

Abstract

Cocoa farmers must decide on whether to rehabilitate (Rh) or to renovate (Re) a cocoa orchard when its productivity declines due to ageing, disease outbreaks or other causes. Deciding on Rh/Re is often a complex, expensive and conflictive process.

In this review, we (1) explore the diversity of contexts, driving forces, stakeholders and recommended management practices involved in Rh/Re initiatives in key cocoa-producing countries; (2) summarise the often conflicting views of farmers and extension agents on Rh/Re programmes; (3) review the evidence of age-related changes in planting density and yield of cocoa, given the weight of these variables in Rh/Re decision processes; (4) describe the best known Rh/Re systems and their most common management practices; (5) propose an agroforestry Re approach that overcomes the limitation of current Rh/Re diagnosis protocols, which do not consider the regular flow of food crop and tree products, and the need to restore site soil quality to sustain another cycle of cultivation of cocoa at the same site; and (6) explore the effects of climate change considerations on Rh/Re decision-making and implementation processes.

Each Rh/Re decision-making process is unique and highly context-dependent (household and farm, soil, climate, culture). Tailored solutions are needed for each farmer and context. The analysis, concepts and models presented for cocoa in this paper may also apply to coffee orchards.
Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata
Authors: Geng Chang-An , Deng Zhen-Tao , Huang Qian , Xiang Chun-Lei , Chen Ji-Jun
Published: September 2021

Ten 3,5-dimethylcoumarins (1–6 and 8‒11) involving six new ones (1–6), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and C. pseudobracteata. The structures of the new compounds were determined by extensive HRESIMS, 1D and 2D NMR spectroscopic analyses. According to the substitution at C-5, these coumarins were classified into 5-methyl, 5-hydroxymethyl, 5-formyl, and 5-nor types. All the isolates were assayed for their inhibition on α-glucosidase, protein tyrosine phosphatase 1B, and T-cell protein tyrosine phosphatase in vitro.

Graphic Abstract
Novel hierarchical structure of MoS2/TiO2/Ti3C2Tx composites for dramatically enhanced electromagnetic absorbing properties
Authors: Du Heng , Zhang Qipeng , Zhao Biao , Marken Frank , Gao Qiancheng , Lu Hongxia , Guan Li , Wang Hailong , Shao Gang , Xu Hongliang , Zhang Rui , Fan Bingbing
Published: September 2021

In order to prevent the microwave leakage and mutual interference, more and more microwave absorbing devices are added into the design of electronic products to ensure its routine operation. In this work, we have successfully prepared MoS2/TiO2/Ti3C2Tx hierarchical composites by one-pot hydrothermal method and focused on the relationship between structures and electromagnetic absorbing properties. Supported by comprehensive characterizations, MoS2 nanosheets were proved to be anchored on the surface and interlayer of Ti3C2Tx through a hydrothermal process. Additionally, TiO2 nanoparticles were obtained in situ. Due to these hierarchical structures, the MoS2/TiO2/Ti3C2Tx composites showed greatly enhanced microwave absorbing performance. The MoS2/TiO2/Ti3C2Tx composites exhibit a maximum reflection loss value of −33.5 dB at 10.24 GHz and the effective absorption bandwidth covers 3.1 GHz (13.9–17 GHz) at the thickness of 1.0 mm, implying the features of wide frequency and light weight. This work in the hierarchical structure of MoS2/TiO2/Ti3C2Tx composites opens a promising door to the exploration of constructing extraordinary electromagnetic wave absorbents.
NUV-pumped luminescence of thermally stable samarium-activated alkali metal borophosphate phosphor
Authors: Fang Zhenyu , Yang Dan , Zheng Youkui , Song Jialiang , Yang Tongsheng , Song Ruitong , Xiang Yuefei , Zhu Jing
Published: September 2021

Exploring outstanding rare-earth activated inorganic phosphors with good thermostability has always been a research focus for high-power white light-emitting diodes (LEDs). In this study, we report a Sm3+-activated KNa4B2P3O13 (KNBP) powder phase. Its particle morphology, photoluminescence properties, concentration quenching mechanism, thermal quenching mechanism, and chromatic properties are demonstrated. Upon the near-ultraviolet (NUV) irradiation of 402 nm, the powder phase exhibits orange-red visible luminescence performance, originating from typical 4G5/2→6HJ/2 (J = 5, 7, 9) transitions of Sm3+. Importantly, the photoluminescence performance has good thermostability, low correlated color temperature (CCT), and high color purity (CP), indicating its promising application in the NUV-pumped warm white LEDs.