bluuebunny/crossref_metadata_2025 huggingface dataset:
Provisioning an Efficient Recommender System to Measure the Players Activities Using Machine Learning Approaches
Authors: Deepak V. , Anguraj Dinesh Kumar
Published: June 2023

Gamification is determined as an efficient tool for monitoring the behavioral nature during daily physical activities. A recommender system for monitoring the players’ activity is achieved by modeling a gamified system. This research concentrates on modeling and efficient Gamified Recommender System (GRS) to acquire the behavior of the individual player by a fitness assessment. Here, the scaling of individual player performance is done with two diverse normalization methods known as Standard and Xcorr normalization to reduce the dependency over the environmental condition during fitness measurements. Unaffected by the weather, a revolutionary machine learning approach is intended to categorize each athlete’s individual stride. Here, an adaptive boosting ([Formula: see text]) algorithm is designed to measure the individual strides of an athlete, and Linear Support Vector Machine ([Formula: see text]) is adapted to classify and generalize the individual fitness activities. The dataset collected from the athletes utilizing internet resources is used to extract the feature subsets. The outcomes show that the suggested approach is effective and workable for developing the Gamified Recommender System in particular. Some statistical difference among the individual performance is provided based on gamified and personalized functions. The positive values of these statistical measures (Wilcoxon statistical measure) help attain the athletes’ preference and motivation level. Moreover, the qualitative outcomes show that the features are efficient for computation and a capable recommender system is designed to attain the fitness goal based on environmental features. MATLAB 2018b is used to run the simulation and the outcomes demonstrate how the GRS model stacks up against several approaches, such as NB, MLP, and the k-star model.
Uncertainty Principles for Teaching Laboratories
Authors: Haglin Kevin L.
Published: June 2023

Educators must make decisions about learner expectations and skills on which to focus when it comes to laboratory activities. There are various approaches but the general pattern is to encourage students to measure ordered pairs, plot a graph to establish linear dependence, and then compute the slope of the best-fit line for an eventual scientific conclusion. To assist educators when they also want to include slope uncertainty dependent upon measurement uncertainty as part of the expected analysis, we demonstrate a physical approach so that both educators and their students have a convenient road map to follow. A popular alternative that educators often choose is to rely solely on statistical metrics to establish the tolerance of the technique, but we argue that the statistical strategy can distract students away from the true meaning of the uncertainty that is inherent in the act of making the measurements. We will carry these measurement error bars from their points of origin through the regression analysis to consistently establish the physical error bars for the slope and the intercept. We then demonstrate the technique using an introductory physics experiment with a purpose of measuring the speed of sound in air.
Experiments of Supervised Learning and Semi-Supervised Learning in Thai Financial News Sentiment: A Comparative Study
Authors: Sangsavate Suntarin , Sinthupinyo Sukree , Chandrachai Achara
Published: June 2023

Sentiment classification is an instrument of natural language processing tasks in text analysis to measure customer feedback from given documents such as product reviews, news, and texts. This research aims to experiment with Thai financial news sentiment classification and evaluate sentiment classification performance. In this research, we show financial news sentiment classification experimental results when comparing supervised and semi-supervised methods. In the research methodology, we use PyThaiNLP to tokenize and remove stopwords and split datasets into 85% of the training set and 15% of the testing set. Next, we classify sentiment using machine learning and deep learning approaches with feature extraction such as bag-of-words, term frequency–inverse document frequency, and word embedding (Word2Vec and Bidirectional Encoder Representations from Transformers (BERT)) in given texts. The results show that support vector machine with the BERT model yields the best performance at 83.38%; in contrast, the random forest classifier with bag-of-words yields the worst performance at 54.10% in the machine learning approach. Another experiment reveals that long short-term memory with the BERT model yields the best performance at 84.07% in contrast to the convolutional neural network with bag-of-words, which yields the worst performance at 69.80% in the deep learning approach. The results imply that support vector machine, convolutional neural network, and long short-term memory are suitable for classifying sentiment in complex structure language. From this study, we observe the importance of sentiment classification tools between supervised and semi-supervised learning, and we look forward to furthering this work.
Ad Hoc Transactions: What They Are and Why We Should Care
Authors: Tang Chuzhe , Wang Zhaoguo , Zhang Xiaodong , Yu Qianmian , Zang Binyu , Guan Haibing , Chen Haibo
Published: June 2023

Many transactions in web applications are constructed ad hoc in the application code. For example, developers might explicitly use locking primitives or validation procedures to coordinate critical code fragments. We refer to database operations coordinated by application code as ad hoc transactions. Until now, little is known about them. This paper presents the first comprehensive study on ad hoc transactions. By studying 91 ad hoc transactions among 8 popular open-source web applications, we find that (i) every studied application uses ad hoc transactions (up to 16 per application), 71 of which play critical roles; (ii) compared with database transactions, concurrency control of ad hoc transactions is much more flexible; (iii) ad hoc transactions are error-prone-53 of them have correctness issues, and 33 of them are confirmed by developers; and (iv) ad hoc transactions have the potential to improve performance in contentious workloads by utilizing application semantics such as access patterns. Finally, implications of ad hoc transactions to the database research community are discussed.
An Optimal Algorithm for Partial Order Multiway Search
Authors: Lu Shangqi , Martens Wim , Niewerth Matthias , Tao Yufei
Published: June 2023

Partial order multiway search (POMS) is an important problem that finds use in crowdsourcing, distributed file systems, software testing, etc. In this problem, a game is played between an algorithm A and an oracle, based on a directed acyclic graph G known to both parties. First, the oracle picks a vertex t in G called the target; then, A aims to figure out which vertex is t by probing reachability. In each probe, A selects a set Q of vertices in G whose size is bounded by a pre-agreed value k, and the oracle then reveals, for each vertex q 2 Q, whether q can reach the target in G. The objective of A is to minimize the number of probes. This article presents an algorithm to solve POMS in O(log1+k n + d k log1+d n) probes, where n is the number of vertices in G, and d is the largest out-degree of the vertices in G. The probing complexity is asymptotically optimal.
Geospatial Analysis and Molecular Epidemiologic Study of Emerging Pulmonary Lophomoniasis in Iran: A National Registry-Based Study
Authors: Ghatee Mohammad Amin , Nakhaei Maryam , Sharifpour Ali , Fakhar Mahdi , Mohamadi Niloufar , Soleymani Mostafa , Abedi Siavash , Aliyali Masoud , Mehravaran Hossein
Published: June 2023

Introduction. Bronchopulmonary lophomoniasis (BPL) is a protozoan pulmonary disease that has been reported sporadically, but its incidence has been increasing. However, the epidemiology and risk factors of the disease have not been clearly identified. The current study aims to identify BPL cases molecularly and assess the demographic and some environmental factors for the first time on the prevalence of BPL as a national registry-based study in Iran. Methodology. The study tested 960 patients with lower respiratory tract symptoms whose bronchoalveolar lavage samples were submitted from seven provinces of Iran to the Iranian National Registry Center for Lophomoniasis. They were tested for BPL by a newly developed polymerase chain reaction test. The study assessed the association of Normalized difference vegetation index (NDVI), digital elevation model (DEM), and geographic latitude as environmental factors and sex and age as demographic factors on the prevalence of BPL. Geospatial information systems methods and chi-squared and Pearson’s correlation tests were used for the assessment of geographical and environmental factor effects and statistical analysis, respectively. Results. Of the 960 patients, 218 (22.7%) tested positive for BPL; the highest and lowest prevalence rates were reported from the south and northeast of Iran, respectively. The study found a correlation between geographic latitude and age with BPL prevalence, but no association was found for gender, NDVI, or DEM. Most patients were over 40 years old, and the rate of disease was higher in southern latitudes. Conclusion. Age and geographical latitude were found to be risk factors for BPL. More exposure to dust and/or chronic pulmonary problems may explain the higher prevalence of the disease in older adults. Higher rates of BPL in lower latitudes may be due to warmer weather and longer days, which can confine individual activities indoors and result in more contact with domestic insects and infected dust.
Causes and Impacts of Delays in Ethiopian Public Construction Projects (Case on Debre Markos University Construction Projects)
Authors: Demissew Abebe , Abiy Fasika
Published: June 2023

The construction project is regarded successful when it is given over to the owner within the time, cost, and standards necessary while minimizing delays in public construction projects. Debre Markos University (DMU) is one of the public universities undergoing massive development projects that are experiencing significant delays. This article evaluates the most prevalent delay issues encountered by Ethiopian government-funded construction projects, particularly those using DMU, analyzes their impacts, and suggests a delay management system. The study applied qualitative as well as quantitative techniques to evaluate primary and secondary data. Per the entirety statistics, the top five most important and highly ranked factors are erroneous time estimates, force majeure, lowest bid, procurement policy, and volatile markets, as well as frequent design changes. Nearly every DMU project schedule overruns up to 268.67% of its contract duration. As a result, the institution suffered from poor public relations and a high cost of supervision and contract administration (6.87% of the overall project cost). Conducting a thorough and accurate project feasibility study, awarding bids to experienced contractors, avoiding drawing discrepancies, preparing an accurate initial time and cost estimate, and strict schedule monitoring were discovered to be effective techniques for reducing delays in public construction projects.
Supplementary Table S2 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Authors: Foote Michael B. , Walch Henry , Kemel Yelena , Vakiani Efsevia , Johannet Paul , Sheehan Margaret , Chatila Walid , Chung Sebastian , Nash Garrett M. , Maio Anna , Shia Jinru , Mandelker Diana , Berger Michael , Schultz Nikolaus , Diaz Luis A. , Cercek Andrea , Stadler Zsofia K.
Published: June 2023

Germline mutations present in the assessed cohort of patients with appendiceal adenocarcinoma.
Supplementary Table S1 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Authors: Foote Michael B. , Walch Henry , Kemel Yelena , Vakiani Efsevia , Johannet Paul , Sheehan Margaret , Chatila Walid , Chung Sebastian , Nash Garrett M. , Maio Anna , Shia Jinru , Mandelker Diana , Berger Michael , Schultz Nikolaus , Diaz Luis A. , Cercek Andrea , Stadler Zsofia K.
Published: June 2023

Genes evaluated by the MSK IMPACT germline sequencing panel
Supplementary Table S3 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: June 2023

Table S3. Sensitivity analysis of the association between plasma 25-hydroxyvitamin level and disease-free survival, overall survival, and time to recurrence, excluding patients who recurred or died within three months of blood collection
Supplementary Figure S2 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Authors: Foote Michael B. , Walch Henry , Kemel Yelena , Vakiani Efsevia , Johannet Paul , Sheehan Margaret , Chatila Walid , Chung Sebastian , Nash Garrett M. , Maio Anna , Shia Jinru , Mandelker Diana , Berger Michael , Schultz Nikolaus , Diaz Luis A. , Cercek Andrea , Stadler Zsofia K.
Published: June 2023

Appendix cancer specific survival in patients with stage IV appendiceal adenocarcinoma stratified by presence of a germline variant in CHEK2 (n=3) or BRCA1(n=1) associated with homologous recombination deficiency (HRD). Patients with germline variants in non-HRD-associated genes were not included in the analysis. Highlighted Kaplan Meier curve areas display the 95% confidence interval for the respective survival curves.
Supplementary Table S2 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: June 2023

Table S2. Representativeness of study participants
Supplementary Figure S1 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Authors: Foote Michael B. , Walch Henry , Kemel Yelena , Vakiani Efsevia , Johannet Paul , Sheehan Margaret , Chatila Walid , Chung Sebastian , Nash Garrett M. , Maio Anna , Shia Jinru , Mandelker Diana , Berger Michael , Schultz Nikolaus , Diaz Luis A. , Cercek Andrea , Stadler Zsofia K.
Published: June 2023

Supplemental Figure 1: Appendix cancer specific survival in patients with stage IV appendiceal adenocarcinoma stratified by presence of a germline variant. Highlighted Kaplan Meier curve areas display the 95% confidence interval for the respective survival curves.
Supplementary Table S1 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: June 2023

Table S1. Baseline characteristics of study participants in the complete clinical trial, plasma biomarker companion study, and diet and lifestyle companion study
Supplementary Methods S1 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: June 2023

Supplementary Methods
Supplementary Figure S3 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: June 2023

Figure S3. Multivariable hazard ratio and 95% confidence intervals for disease-free survival (A), overall survival (B), and time to recurrence (C), comparing plasma 25-hydroxyvitamin D ≥12 versus <12 ng/ml, across strata of potential effect modifiers
Supplementary Figure S2 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: June 2023

Figure S2. Dose-response relationship and test of linearity for the hazard ratio (HR) of disease-free survival (A), overall survival (B), and time to recurrence (C) by continuous predicted vitamin D scores, with reference of plasma 25-hydroxyvitamin D set at 12 ng/ml
Table S3 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Authors: Jung In-Young , Bartoszek Robert L. , Rech Andrew J. , Collins Sierra M. , Ooi Soon-Keat , Williams Erik F. , Hopkins Caitlin R. , Narayan Vivek , Haas Naomi B. , Frey Noelle V. , Hexner Elizabeth O. , Siegel Donald L. , Plesa Gabriela , Porter David L. , Cantu Adrian , Everett John K. , Guedan Sonia , Berger Shelley L. , Bushman Frederic D. , Herbst Friederike , Fraietta Joseph A.
Published: June 2023

Chromatin accessibility profiles for EGR2 knockout (KO) and AAVS1 knockout (AAVS1) CD8+ CAR T-cells. The table provides information on the locus mapping, p-value, average log2 fold change, percentage of cells, adjusted p-value, transcript ID, gene name, gene ID, gene biotype, region type, closest region, query region, and distance.
Figure S8 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Authors: Jung In-Young , Bartoszek Robert L. , Rech Andrew J. , Collins Sierra M. , Ooi Soon-Keat , Williams Erik F. , Hopkins Caitlin R. , Narayan Vivek , Haas Naomi B. , Frey Noelle V. , Hexner Elizabeth O. , Siegel Donald L. , Plesa Gabriela , Porter David L. , Cantu Adrian , Everett John K. , Guedan Sonia , Berger Shelley L. , Bushman Frederic D. , Herbst Friederike , Fraietta Joseph A.
Published: June 2023

Comparison of Type I IFN gene expression in different CAR-T engineering approaches. (A-F) show volcano plots and a heatmap of gene expression in engineered CAR T-cells, with type I IFN genes highlighted in blue. These data represent different CAR-T engineering approaches, including: BRG1/BRM-associated factors (BAF) complex, Gata3, INO80 complex knockout (PMID35750052), BATF overexpression (PMID34282330), 4-1BB- versus CD28-based GD2 CAR activity (PMID 25939063) and 1xx CD19 CAR T-cells (GSE121226). These plots allow for a comparison of the levels of type I IFN gene expression in each of these different CAR-T engineering methods.
Figure S5 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Authors: Jung In-Young , Bartoszek Robert L. , Rech Andrew J. , Collins Sierra M. , Ooi Soon-Keat , Williams Erik F. , Hopkins Caitlin R. , Narayan Vivek , Haas Naomi B. , Frey Noelle V. , Hexner Elizabeth O. , Siegel Donald L. , Plesa Gabriela , Porter David L. , Cantu Adrian , Everett John K. , Guedan Sonia , Berger Shelley L. , Bushman Frederic D. , Herbst Friederike , Fraietta Joseph A.
Published: June 2023

Gene expression and pathway enrichment analysis of CD8+ T cell clusters. A, Heatmap showing differentially expressed genes between memory-like KLF2+ and exhausted-like MKI67+ CD8+ T-cells. Gene signature scores related to cell cycle and clinical response are indicated on the top bars. B, Top downregulated GO biological processes in EGR2 compared to AAVS1 knockout CAR T-cells.
Figure S4 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Authors: Jung In-Young , Bartoszek Robert L. , Rech Andrew J. , Collins Sierra M. , Ooi Soon-Keat , Williams Erik F. , Hopkins Caitlin R. , Narayan Vivek , Haas Naomi B. , Frey Noelle V. , Hexner Elizabeth O. , Siegel Donald L. , Plesa Gabriela , Porter David L. , Cantu Adrian , Everett John K. , Guedan Sonia , Berger Shelley L. , Bushman Frederic D. , Herbst Friederike , Fraietta Joseph A.
Published: June 2023

Marker gene expression in CAR T-cell clusters. A, Uniform manifold approximation and projection (UMAP) plot of AAVS1 and EGR2 knockout (KO) CAR T-cell samples is shown. B, UMAP plots showing expression levels of CD4 and CD8. C, Violin plot depicting expression of cluster-defining markers in CD4+ T-cells. D, Differentially expressed genes in IL7R+ versus CTLA4+ CD4+ T-cells. E, Violin plots showing expression levels of cluster-defining markers in CD8+ T-cells. F, Heatmap displaying differentially expressed genes between CD8+ cell clusters. G, Cell cycle scores mapped on UMAP plots.
Figure S10 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Authors: Jung In-Young , Bartoszek Robert L. , Rech Andrew J. , Collins Sierra M. , Ooi Soon-Keat , Williams Erik F. , Hopkins Caitlin R. , Narayan Vivek , Haas Naomi B. , Frey Noelle V. , Hexner Elizabeth O. , Siegel Donald L. , Plesa Gabriela , Porter David L. , Cantu Adrian , Everett John K. , Guedan Sonia , Berger Shelley L. , Bushman Frederic D. , Herbst Friederike , Fraietta Joseph A.
Published: June 2023

EGR2 knockout enhances the long-term potency and memory function of CAR T-cells in vivo. A, Schematic of the tumor rechallenge experiments. B, Tumor growth after the first (left) and second (right) NALM6 challenges (Mann-Whitney test, n = 10). C, Mouse survival after high-dose second tumor challenge (Log-rank test). D, Tumor growth inhibition in a prostate cancer model using PSMA-targeting CAR T-cells with EGR2 or AAVS1 knockout (KO) compared to control CD19 CAR T-cells (19BBz). The tumor growth was monitored over time using caliper-based measurements in NSG mice (n = 8).
Figure S1 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Authors: Jung In-Young , Bartoszek Robert L. , Rech Andrew J. , Collins Sierra M. , Ooi Soon-Keat , Williams Erik F. , Hopkins Caitlin R. , Narayan Vivek , Haas Naomi B. , Frey Noelle V. , Hexner Elizabeth O. , Siegel Donald L. , Plesa Gabriela , Porter David L. , Cantu Adrian , Everett John K. , Guedan Sonia , Berger Shelley L. , Bushman Frederic D. , Herbst Friederike , Fraietta Joseph A.
Published: June 2023

Analysis of EGR2 and type I IFN pathway regulation in CAR T-cells. (A-C) ATAC-seq tracks of genes associated with dysfunction, type I IFN signaling, and memory differentiation are shown, with differentially accessible regions indicated. D, Heatmap showing expression of exhaustion genes in tonically signaling GD2 and functional CD19 naïve CD8+ CAR-T cells (GSE136891). E, Comparison of EGR2 and type I IFN gene signature scores in central memory CD8+ T-cells expressing a tonically signaling GD2 CAR and control CD19 CAR. CAR T-cells were generated using T-cells from a healthy donor (GSE136891). F, Top transcription factor co-expression signatures overexpressed in CD19 CAR T-cell products of CLL complete responders. G, Comparison of EGR2 and type I IFN signature scores in unstimulated CD19 CAR T-cell products from CLL patients (CR: complete response, PRTD: very good partial response, PR: conventional partial response, NR: no response). H, Comparison of type I IFN and EGR2 module scores in PSMA CAR T-cells from lymphodepleted prostate cancer patients, and their association with in vivo CAR T-cell proliferation and PSA decline.
Supplementary Table 1 from NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) Plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Authors: Cecchini Michael , Walther Zenta , Wei Wei , Hafez Navid , Pilat Mary Jo , Boerner Scott A , Durecki Diane E , Eder Joseph P , Schalper Kurt A. , Chen Alice P. , LoRusso Patricia
Published: June 2023

Molecular results and outcomes for each patient.
Supplementary Methods 1 from NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) Plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Authors: Cecchini Michael , Walther Zenta , Wei Wei , Hafez Navid , Pilat Mary Jo , Boerner Scott A , Durecki Diane E , Eder Joseph P , Schalper Kurt A. , Chen Alice P. , LoRusso Patricia
Published: June 2023

The clinical trial protocol for NCI 7977.
Supplementary Figure S5 from Targeting the clear cell sarcoma oncogenic driver fusion gene EWSR1:ATF1 by HDAC inhibition
Authors: Mae Hirokazu , Outani Hidetatsu , Imura Yoshinori , Chijimatsu Ryota , Inoue Akitomo , Kotani Yuki , Yasuda Naohiro , Nakai Sho , Nakai Takaaki , Takenaka Satoshi , Okada Seiji
Published: June 2023

Fig. S5
A combination of vorinostat and mivebresib is effective for CCS
Supplementary Figure S4 from Targeting the clear cell sarcoma oncogenic driver fusion gene EWSR1:ATF1 by HDAC inhibition
Authors: Mae Hirokazu , Outani Hidetatsu , Imura Yoshinori , Chijimatsu Ryota , Inoue Akitomo , Kotani Yuki , Yasuda Naohiro , Nakai Sho , Nakai Takaaki , Takenaka Satoshi , Okada Seiji
Published: June 2023

Fig. S4
The SOX10 knockdown and overexpression efficiency.
Supplementary Figure 1 from NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) Plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Authors: Cecchini Michael , Walther Zenta , Wei Wei , Hafez Navid , Pilat Mary Jo , Boerner Scott A , Durecki Diane E , Eder Joseph P , Schalper Kurt A. , Chen Alice P. , LoRusso Patricia
Published: June 2023

Trial profile for enrolled patients.
TABLE 2 from A Phase I/II Clinical Trial of Pembrolizumab and Cabozantinib in Metastatic Renal Cell Carcinoma
Authors: Kessler Elizabeth R. , Callihan Eryn , Hu Junxiao , Eule Corbin , Srivastava Geetika , Kemme Douglas J. , Iruku Praveena , Rana Vishal , Moore James , Schuster Steven R. , Amirault Mali , Flaig Thomas W. , Lam Elaine T.
Published: June 2023

TRAEs in ≥10% of patients and all grade ≥3
Supplementary Table S2 from A Phase I/II Clinical Trial of Pembrolizumab and Cabozantinib in Metastatic Renal Cell Carcinoma
Authors: Kessler Elizabeth R. , Callihan Eryn , Hu Junxiao , Eule Corbin , Srivastava Geetika , Kemme Douglas J. , Iruku Praveena , Rana Vishal , Moore James , Schuster Steven R. , Amirault Mali , Flaig Thomas W. , Lam Elaine T.
Published: June 2023

Best Response by RECIST in Evaluable Patients Treated at the Pembrolizumab 200 mg IV Q3W and Cabozantinib 40 mg PO QD Cohort
Supplementary Table S1 from A Phase I/II Clinical Trial of Pembrolizumab and Cabozantinib in Metastatic Renal Cell Carcinoma
Authors: Kessler Elizabeth R. , Callihan Eryn , Hu Junxiao , Eule Corbin , Srivastava Geetika , Kemme Douglas J. , Iruku Praveena , Rana Vishal , Moore James , Schuster Steven R. , Amirault Mali , Flaig Thomas W. , Lam Elaine T.
Published: June 2023

Best Response by RECIST in Evaluable Patients Treated at RP2D (Pembrolizumab 200 mg IV Q3W and Cabozantinib 60 mg PO QD) by Prior Therapy
Supplementary Figure S1 from A Phase I/II Clinical Trial of Pembrolizumab and Cabozantinib in Metastatic Renal Cell Carcinoma
Authors: Kessler Elizabeth R. , Callihan Eryn , Hu Junxiao , Eule Corbin , Srivastava Geetika , Kemme Douglas J. , Iruku Praveena , Rana Vishal , Moore James , Schuster Steven R. , Amirault Mali , Flaig Thomas W. , Lam Elaine T.
Published: June 2023

Supplemental Figure S1: Kaplan-Meier curves of (A) progression-free survival (PFS) and (B) overall survival (OS) for patients with clear cell renal cell carcinoma histology (N=34). Vertical lines show censored patients
FIGURE 3 from A Phase I/II Clinical Trial of Pembrolizumab and Cabozantinib in Metastatic Renal Cell Carcinoma
Authors: Kessler Elizabeth R. , Callihan Eryn , Hu Junxiao , Eule Corbin , Srivastava Geetika , Kemme Douglas J. , Iruku Praveena , Rana Vishal , Moore James , Schuster Steven R. , Amirault Mali , Flaig Thomas W. , Lam Elaine T.
Published: June 2023

Kaplan–Meier curves of PFS (A) and OS (B) for all patients treated at the RP2D of pembrolizumab 200 mg i.v. every 3 weeks and cabozantinib 60 mg orally once daily (N = 40). Vertical lines show censored patients.
FIGURE 1 from A Phase I/II Clinical Trial of Pembrolizumab and Cabozantinib in Metastatic Renal Cell Carcinoma
Authors: Kessler Elizabeth R. , Callihan Eryn , Hu Junxiao , Eule Corbin , Srivastava Geetika , Kemme Douglas J. , Iruku Praveena , Rana Vishal , Moore James , Schuster Steven R. , Amirault Mali , Flaig Thomas W. , Lam Elaine T.
Published: June 2023

CONSORT diagram and patient disposition. DLT, dose-limiting toxicity; RP2D, recommended phase II dose; P, pembrolizumab; C, cabozantinib.
Cardiovascular Measures of All-Cause Mortality in Duchenne Muscular Dystrophy
Authors: Soslow Jonathan H. , Xu Meng , Slaughter James C. , Crum Kimberly , Kaslow Jacob A. , George-Durrett Kristen , Raucci Frank J. , Wilkinson James D. , Cripe Linda H. , Hor Kan N. , Spurney Christopher F. , Markham Larry W.
Published: June 2023

Background:

Cardiopulmonary failure is the leading cause of death in Duchenne muscular dystrophy (DMD). Research into DMD-specific cardiovascular therapies is ongoing, but there are no Food and Drug Administration-approved cardiac end points. To adequately power a therapeutic trial, appropriate end points must be chosen and the rate of change for these end points reported. The objective of this study was to evaluate rate of change for cardiac magnetic resonance and blood biomarkers and to determine which measures associate with all-cause mortality in DMD.

Methods:

Seventy-eight DMD subjects underwent 211 cardiac magnetic resonance studies analyzed for left ventricular (LV) ejection fraction, indexed LV end diastolic and systolic volumes, circumferential strain, late gadolinium enhancement presence and severity (global severity score, and full width half maximum), native T1 mapping, T2 mapping, and extracellular volume. Blood samples were analyzed for BNP (brain natriuretic peptide), NT-proBNP (N-terminal pro-B-type natriuretic peptide), and troponin I. Cox proportional hazard regression modeling was performed with all-cause mortality as the outcome.

Results:

Fifteen subjects (19%) died. LV ejection fraction, indexed end systolic volumes, global severity score, and full width half maximum worsened at 1 and 2 years while circumferential strain and indexed LV end diastolic volumes worsened at 2 years. LV ejection fraction, indexed LV end diastolic and systolic volumes, late gadolinium enhancement full width half maximum, and circumferential strain associated with all-cause mortality (
P
<0.05). NT-proBNP was the only blood biomarker that associated with all-cause mortality (
P
<0.05).

Conclusions:

LV ejection fraction, indexed LV volumes, circumferential strain, late gadolinium enhancement full width half maximum, and NT-proBNP are associated with all-cause mortality in DMD and may be the best end points for use in cardiovascular therapeutic trials. We also report change over time of cardiac magnetic resonance and blood biomarkers.
Molecular Biomarkers for Cardiometabolic Disease: Risk Assessment in Young Individuals
Authors: Tahir Usman A. , Gerszten Robert E.
Published: June 2023

Cardiometabolic diseases, including cardiovascular disease and diabetes, are major causes of morbidity and mortality worldwide. Despite progress in prevention and treatment, recent trends show a stalling in the reduction of cardiovascular disease morbidity and mortality, paralleled by increasing rates of cardiometabolic disease risk factors in young adults, underscoring the importance of risk assessments in this population. This review highlights the evidence for molecular biomarkers for early risk assessment in young individuals. We examine the utility of traditional biomarkers in young individuals and discuss novel, nontraditional biomarkers specific to pathways contributing to early cardiometabolic disease risk. Additionally, we explore emerging omic technologies and analytical approaches that could enhance risk assessment for cardiometabolic disease.
Black Queer Fugitivity: Agency, Language, and Digital Joy
Authors: Taylor Leonard D. , Harry Dion T. , Blockett Reginald A.
Published: June 2023

Moving beyond axial considerations, we recount the experiences of Black queer educators and the literacies we engage in for survival and thriving (Blockett et al. 2022). In our pointed exploration of virtual and physical, we consider anti-Black and anti-queer moments as sites of fugitivity – a Black resistance formation (Best & Hartman 2005; Givens 2021). For this paper, we focus on non-conventional, un-codified, rule-defying literacies that Black queer people have and continued to engage to resist, subvert, decenter, exist, and create. In doing so we provide insight into the survival and agency of Black queer people, and invite opportunities to consider new possible futures for the experiences of Black queer educators.
Queer Worldmaking in Animal Crossing: Disruptive and Joyful Critical Media Literacies
Authors: Shelton Stephanie Anne , Coogler Carlson H. , Watson Venus
Published: June 2023

While the educational possibilities for the Nintendo Switch video game Animal Crossing: New Horizon seem near-endless, we have been particularly struck with the game’s worldmaking potential, and the ways that such opportunities push against pervasive anti-queer and anti-trans educational legislation, while offering queer- and trans- affirming communities and creativity for players. Through analysis of online gaming communities, online gaming community, and authors’ gameplay, this paper explores the research question: How does acnh afford players opportunities to engage in queer- and trans-affirming worldmaking through critical media literacies? Our findings include considerations of the in-game gender elasticity afforded players and player-created online lgbtq+ communities.
Carbon fiber reinforced poly(lactic acid) composites: Investigation the effects of graphene nanoplatelet and coupling agent addition
Authors: Karsli Nevin Gamze
Published: June 2023

Although petroleum-based polymers require a long process to decompose in nature, they still have a wide range of uses. However, due to many important reasons such as the environmental pollution problem caused by these polymers, there is an increasing interest in biodegradable polymers. Poly(lactic acid) (PLA) is a biopolymer with comparable performance to conventional polymers. However, due to its poor tribological, mechanical and thermal properties, the usage area of PLA cannot expand and its use is limited to short-term material applications. In this study, it was aimed to contribute to the expansion of the usage area of PLA by improving its poor properties. For this purpose, efficiency of graphene nanoplatelet (GnP) and/or Joncryl® addition to carbon fiber (CF) reinforced PLA matrix composites to improve the composite performance by means of improved interface interaction fiber and matrix was investigated. Within this scope, effects the separately and/or simultaneously addition of CF, GnP and Joncryl® to PLA on properties were investigated by tensile test, adhesive wear test, DSC, TGA and SEM analyses. All results revealed that the composite composition prepared by simultaneously addition of 10, 0.5 and 2 wt.% CF, GnP and Joncryl®, respectively, to pure PLA performed the best in all tests and analyses.
Gluteal Muscle Size and Quality in Professional Ballet Dancers Compared to Non-Dancing Athletes
Authors: McMillan Rachael Mary , Mayes Susan , Cook Jillianne , Semciw Adam Ivan , Plass Lindsey Marie , Pizzari Tania
Published: June 2023

Introduction:

Professional ballet dancers load their hips in extreme ranges of motion and commonly report hip pain. Evaluating gluteal muscle size and quality may help guide exercise programs. Objectives of this study were to compare gluteal muscle size and quality (fatty infiltration) in ballet dancers compared to athletes; and to investigate the relationship between gluteal muscle size and quality, and reports of hip-related pain.

Methods:

This study was a case-control design. Professional ballet dancers (current and retired, n = 49, mean age 35 years, range 19-63) and age and sex-matched athletes (current and retired, n = 49) underwent magnetic resonance imaging of both hips. Muscle cross-sectional areas (CSA) were obtained at standardized landmarks for gluteus maximus (GMax) and gluteus medius (GMed). Full muscle volume was calculated for gluteus minimus (GMin). Fatty infiltration was rated using the Goutallier classification system. Muscle size was compared between groups using linear mixed models. Fatty infiltration was compared using a mixed model binary logistic regression. Hip-related pain, participation status, limb side and sex were included as covariates.

Results:

Ballet dancers had significantly larger GMax (upper P < .01, middle P < .01, lower P = .01) and GMed (level of anterior inferior iliac spine P < .01, greater sciatic foramen P < .01) CSA and larger GMin volume ( P < .01), when normalized to weight. There was no difference in fatty infiltration ratings between dancers and non-dancing athletes. Retired dancers and athletes reporting hip-related pain were more likely to have fatty infiltration in GMax lower ( P = .04).

Conclusion:

Gluteal muscles are larger in ballet dancers compared to athletes suggesting high-level loading of these muscles. There is no relationship between hip-related pain and gluteal muscle size. Dancers and athletes have comparable muscle quality.
Is journalism just a job? Findings on journalists’ career motivation, news efficacy and news avoidance from structural equation modeling in China
Authors: Yu Xin , Wang Jinpeng
Published: June 2023

With the profound transformation of Chinese journalism under the commercialized trend of thoughts, there is a debate on whether Chinese journalists still maintain the public service ideal or just regard it simply as a job. In other words, is journalism a “vocation” or a “profession”? Therefore, it is necessary to conduct an empirical study on journalistic roles. Drawing on the self-determination theory, this study constructs a framework of “career motivation–news attitude” to build a bridge between role orientations and performance, in order to comprehensively understand the Chinese journalistic roles. In this study, a quota sampling survey ( n = 1000), multiple linear regression (MLR), and structural equation modeling (SEM) are used to examine the influence of advocacy and utilitarian motivations on news efficacy and news avoidance, corresponding to news production and consumption attitudes. Furthermore, the study divides the journalistic roles in China into four categories: purposive advocate professionals, dedicated advocate professionals, workaday journalists, and adrift journalists. The results show that advocacy motivation, or the public service ideal, is more significant than utilitarian motivation in the journalistic roles. The former is associated with higher news efficacy and lower news avoidance, while the latter is only associated with higher news avoidance. The study also discusses the demographic factors of journalistic career motivations.
A juvenile pleomorphic adenoma of the palate
Authors: Hammami Bouthaina , Achour Imen , Yousfi Ghada , Walha Omar , Mnejja Malek , Chaabouni Mohamed Amin , Charfeddine Ilhem
Published: June 2023

Salivary gland tumors in children are rare; involvement of accessory salivary glands is exceptional. We report a case of pleomorphic adenoma of the palate in a child (an 8-year-old girl) addressed by her dentist for discovering a swelling in the palate. Clinical examination revealed a firm, non-tender, nodular swelling in the left hard palate, measuring 1.5 cm × 1.5 cm, situated adjacent to the upper left second molar. Physical examination did not show signs of inflammation or surface ulceration. Oral cavity computed tomography scan did not show bone lysis. The tumor was removed with negative margins. No recurrence was noted. We aim to describe the clinical, radiological features, as well as the management of this rare localization of pleomorphic adenoma.
Factors associated with fall risk of community-dwelling older people: A decision tree analysis
Authors: Fong Kenneth N K , Chung Raymond C K , Sze Patrick P C , NG Carmen K M
Published: June 2023

Objective

To examine the predictive attributes for accidental falls in community-dwelling older people in Hong Kong using decision tree analysis.

Methods

We recruited 1151 participants with an average age of 74.8 years by convenience sampling from a primary healthcare setting to carry out the cross-sectional study over 6 months. The whole dataset was divided into two sets, namely training set and test set, which respectively occupied 70% and 30% of the whole dataset. The training dataset was used first; decision tree analysis was used to identify possible stratifying variables that could help to generate separate decision models.

Results

The number of fallers was 230 with 20% 1-year prevalence. There were significant differences in gender, use of walking aids, presence of chronic diseases, and co-morbidities including osteoporosis, depression, and previous upper limb fractures, and performance in the Timed Up and Go test and the Functional Reach test among the baselines between the faller and non-faller groups. Three decision tree models for the dependent dichotomous variables (fallers, indoor fallers, and outdoor fallers) were generated, with overall accuracy rates of the models of 77.40%, 89.44% and 85.76%, respectively. Timed Up and Go, Functional Reach, body mass index, high blood pressure, osteoporosis, and number of drugs taken were identified as stratifying variables in the decision tree models for fall screening.

Conclusion

The use of decision tree analysis for clinical algorithms for accidental falls in community-dwelling older people creates patterns for decision-making in fall screening, which also paves the way for utility-based decision-making using supervised machine learning in fall risk detection.
Identification of USP9X as a leukemia susceptibility gene
Authors: Sisoudiya Saumya Dushyant , Mishra Pamela , Li He , Schraw Jeremy M. , Scheurer Michael E. , Salvi Sejal , Doddapaneni Harsha , Muzny Donna , Mitchell Danielle , Taylor Olga , Sabo Aniko , Lupo Philip J. , Plon Sharon E.
Published: June 2023

We recently reported that children with multiple birth defects have a significantly higher risk of childhood cancer. We performed whole-genome sequencing on a cohort of probands from this study with birth defects and cancer and their parents. Structural variant analysis identified a novel 5 kb de novo heterozygous inframe deletion overlapping the catalytic domain of USP9X in a female proband with multiple birth defects, developmental delay, and B-cell acute lymphoblastic leukemia (B-ALL). Her phenotype was consistent with female-restricted X-linked syndromic intellectual developmental disorder-99 (MRXS99F). Genotype-phenotype analysis including previously reported female probands (n = 42) demonstrated that MRXS99F probands with B-ALL (n = 3) clustered with subjects with loss-of-function (LoF) USP9X variants and multiple anomalies. The cumulative incidence of B-ALL among these female probands (7.1%) was significantly higher than an age- and sex-matched cohort (0.003%) from the Surveillance, Epidemiology, and End Results database (P < .0001, log-rank test). There are no reports of LoF variants in males. Males with hypomorphic missense variants have neurodevelopmental disorders without birth defects or leukemia risk. In contrast, in sporadic B-ALL, somatic LoF USP9X mutations occur in both males and females, and expression levels are comparable in leukemia samples from both sexes (P = .54), with the highest expressors being female patients with extra copies of the X-chromosome. Overall, we describe USP9X as a novel female-specific leukemia predisposition gene associated with multiple congenital, neurodevelopmental anomalies, and B-ALL risk. In contrast, USP9X serves as a tumor suppressor in sporadic pediatric B-ALL in both sexes, with low expression associated with poorer survival in patients with high-risk B-ALL.
Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke
Authors: Niu Mu , Zhou Zhikang , Wang Long , Yang Jian , Sun Miao , Lv Xin , Zhang Faqiang
Published: June 2023

Background

Myocardial injury post-stroke is a common sequela of acute stroke. Triglyceride-glucose index (TyG index), a valuable surrogate indicator of insulin resistance, has been suggested to be closely related to cardiovascular outcomes. However, it is unknown whether the TyG index is independently associated with a higher risk of myocardial injury post-stroke. We therefore investigated the longitudinal association between TyG index and risk of myocardial injury post-stroke in older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities.

Methods

We included older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities between January 2021 to December 2021. The individuals were stratified into low and high TyG index groups according to the optimal cutoff value with TyG index. We performed logistic regression analysis, propensity score matching (PSM) analysis, restricted cubic spline analysis, and subgroup analyses to explore the longitudinal association between TyG index and risk of myocardial injury post-stroke.

Results

We included 386 individuals with a median age of 69.8 years (interquartile range: 66.6, 75.3). The optimal TyG index cut-off for predicting myocardial injury post-stroke was 8.9 (sensitivity 67.8%; specificity 75.5%; area under curve 0.701). Multivariate logistic regression analysis revealed that the risk of genesis of myocardial injury post-stroke increased with elevated TyG index (odds ratio [OR], 2.333; 95% confidence interval [CI], 1.201–4.585; P = 0.013). Furthermore, all covariates were well balanced between the two groups. The longitudinal association between TyG index and myocardial injury post-stroke remained significantly robust (OR: 2.196; 95% CI: 1.416–3.478; P < 0.001) after PSM adjustment.

Conclusion

Individuals with an elevated TyG index were more susceptible to having an increased risk of myocardial injury post-stroke. TyG index thus might be served as a complementary approach for optimized-for-risk stratification in older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities.