bluuebunny/crossref_metadata_2025 huggingface dataset:
A gravidade do neoliberalismo radical pós 2008 e nossas estratégias de resistência
Authors: Vasconcelos Eduardo Mourao
Published: September 2020

Este ensaio foi escrito para servir de texto provocador de debates no presente número do periódico Argumento, tendo como tema central “as políticas de saúde mental no Brasil e no plano internacional: tendências e desafios”. No entanto, o texto recoloca esse tema no contexto das atuais profundas transformações na conjuntura política mundial e brasileira, com seu atual projeto histórico neoliberal em uma versão ainda mais radical, capaz de nos levar a uma crise civilizatória e barbárie. O texto parte da caracterização mais reconhecida das políticas neoliberais, para se aprofundar nas estratégias de desmonte das bases históricas que conformaram o sentido de sociedade, solidariedade, justiça social, Estado social e da própria democracia, estratégias já delineadas por seus autores clássicos, como Friedman e Hayek, mas que ainda encontrava alguma resistência nos partidos liberais, que conservavam algum senso de direitos humanos. Após a crise econômica de 2008, as forças políticas de ultradireita deixaram o grande guarda chuva dessas lideranças liberais, e traçaram caminhos próprios, conquistando governos ou aumentando sua presença nos parlamentos. O texto ainda aborda a radicalização das mudanças na esfera do trabalho; as novas tecnologias digitais e suas profundas implicações epistemológicas, políticas e subjetivas, e sua apropriação atual pelas forças de ultradireita; e as novas ‘velhas’ formas violentas e radicais de gestão de ‘populações indesejáveis’, expressas pela noção de necropolítica. Finalmente, o texto convida o leitor para desenvolver sua análise da conjuntura histórica mais ampla, para prever tanto os desafios, como também as possíveis contradições, que apontam para brechas e espaços políticos de atuação e resistência.
O lugar das estratégias de resistência para a Luta Antimanicomial
Authors: Leal Fabiola Xavier
Published: September 2020

Texto Debate  do Ensaio “Estamos compreendendo a gravidade do projeto neoliberal radical que emergiu após a crise de 2008, para traçar nossas estratégias de resistência e luta? de Eduardo Mourão Vasconcelos.
Epifisiólisis femoral proximal, una entidad desapercibida en atención primaria
Authors: González Bateca Christian José
Published: September 2020

La epifisiólisis femoral proximal o deslizamiento capital femoral es un trastorno de la cadera que se caracteriza por un desplazamiento de la epífisis sobre la metáfisis a través de la fisis (cartílago de crecimiento), quedando la epífisis posterior e inferior. Es una entidad relativamente frecuente en atención primaria y prehospitalaria que genera dolor y limitación de cadera; sin embargo, por su sintomatología vaga es usualmente infradiagnosticada o es diagnosticada tardíamente generando consecuencias a largo plazo. Si se tienen en cuenta los factores de riesgo asociados a una adecuada exploración física y el uso imágenes diagnósticas se lograría hacer un diagnóstico oportuno y una disminución de la tasa de complicaciones.
Determination of amino acid profile for argininosuccinic aciduria disorder using High-Performance Liquid Chromatography with fluorescence detection
Authors: Salmanizadeh Hossein , Sahi Neda
Published: September 2020

Argininosuccinic aciduria is an autosomal, recessive amino acid disorder that is caused by a deficiency of the argininosuccinate lyase enzyme. Citrulline is the most significant marker to detect this disorder. We used the High-performance liquid chromatography with fluorescence detection with 450 nm emission and 330 nm excitation wavelengths, 15 mmol/L potassium dihydrogen phosphate and 5 mmol/L dipotassium hydrogen phosphate as Mobile Phase A, and 50 mL water, 250 mL acetonitrile, and 200 mL methanol as Mobile Phase B in gradient mode with flow rate of 1.2 mL/min. The citrulline concentration was 22 µmol/L in healthy infants and 220 µmol/L in infants suffering from the disorder.
The Ecological Factors associated with Non-Melanoma Skin Cancer in Patients referring to the Tumor Clinic of Razi Skin Hospital, Tehran in 2017 (a case-control study)
Authors: Mazloomi Mahmoodabad Seyed Saeed , Abedini Robabeh , Namayandeh Seyedeh Mahdyeh , Nasimi Maryam , Khoda Mahsa , Nazari Zahra
Published: September 2020

Introduction: Due to the high global incidence of skin cancer, its adverse effects on health, and imposition of exorbitant treatment costs on people, the ecological factors associated with non-melanoma skin cancer (NMSC) were examined in patients who referred to the Tumor Clinic of Razi Skin Hospital, Tehran in 2017.
Methods: This case-control study was conducted by administration of a researcher-made questionnaire to collect data from 300 case and 300 control participants selected by convenience sampling method. Inclusion criteria included diagnosis of the NMSC disease by a physician through biopsy and pathology tests. Data were analyzed using descriptive and inferential statistical tests by SPSS software.
Results: A statistically significant relationship was found between NMSC and type of job, socioeconomic status, alcohol and tobacco use, preventive behavioral habits, well water consumption, use of virtual networks, burns, family history, consumption of fatty foods, age / gender, and weight variables. Moreover, NMSC had no statistically significant relationship with the variables of height, body mass index, and urban or rural residence.
Conclusion: Screening programs should be applied for early detection of this disease in its early stages among older men, especially those who have been exposed to a lot of sunlight due to their occupation.
KONTRIBUSI IMAM AL-GHAZALI TERHADAP EKSISTENSI TASAWUF
Authors: Asmaran Asmaran
Published: September 2020

In the first and second centuries of the Hijrah before the presence of Imam al-Ghazali, whose teachings of Sufism at that time were moral and practical, in the third and fourth centuries of Hijrah the teachings of Sufism developed towards philosophical understandings such as Ittihad and Hulul which are viewed by some scholars (theologians and fuqaha) have deviated from the teachings of Islam, as a result of which Sufism almost dies. In such a situation, in the fifth century AH, Imam al-Ghazali appeared to save him by trying to integrate between the teachings of Sufism with the teachings of fiqh and kalam, between fact and sharia, as can be seen in his book Ihya '' Ulum al-Din (Reviving the Sciences Religion), so he is often referred to as Hujjatul Islam (Defender of Islam) because of his efforts to harmonize the teachings of Islam in complete unity.
Empatía y Diseño en un contexto de inmigración
Authors: Martinez Azaro Victoria
Published: September 2020

Elaborando sobre conceptos del lenguaje como elemento que construye, constituye, forma y determina valores personales y sociales, este artículo cuestiona ideas en cuanto a la producción creativa y su relación con procesos sustentables de empatía. Adoptando una mirada de auto reflexión sobre la base de elementos presentes en la producción de la obra de la autora, como diseñadora de Indumentaria y artista plástica, se pone en evidencia la tensión y conflicto entre sentimientos de dislocación y su relación con intereses teóricos que han informado los procesos creativos de la autora. Una exploración teórica a su producción creativa como inmigrante Latina en Nueva Zelanda y el desplazamiento en cuanto a su autopercepción informan la base de este escrito.
La enseñanza de la metodología de la investigación en la era de la invención: Hacia un nuevo humanismo
Authors: Eiriz Claudio
Published: September 2020

Parte del debate respecto de la enseñanza se circunscribe a la discusión acerca de la incorporación de las nuevas tecnologías en el aula y a la comprensión de la subjetividad de los alumnos en la actualidad (millennials). Los modos de interacción social están cambiando y en tanto los estilos de apropiación del conocimiento son tributarios de los modelos disponibles en la efectividad social, es natural que se interprete que los modos en que las nuevas generaciones se apropian del conocimiento, también esté cambiando. Sin embargo, el modo que le damos sentido a los efectos posibles de esa transformación, forman parte de la producción del cambio mismo. En esta ponencia se intenta reflexionar acerca del discurso respecto de los estilos de aprendizaje de las nuevas generaciones, los cambios que se han producidos a partir de las Tics y posteriormente en la consecuencia que estos cambios pueden traer en la enseñanza de la metodología de la investigación, haciendo especial énfasis en los contextos de descubrimiento e invención.
Identidad y nacionalismo. Una mirada sobre la búsqueda de identidad y nuevas tendencias en el diseño de modas
Authors: Bertuzzi María Florencia , Escobar Daniela
Published: September 2020

Hablar de la situación en la que el mundo se encuentra actualmente resulta contradictorio. Por un lado, es innegable la masificación que produce la globalización, por tanto, la unidad existente entre los distintos países y las nuevas formas de comunicación y acceso a la información posibilitan la conexión instantánea a nivel global; mientras que por otro lado hay una enorme necesidad de diferenciación y, en este sentido, la vuelta a las raíces y la exploración dentro del territorio de origen han dado un nuevo sentido a la moda y le ha otorgado un nuevo rol al diseñador de indumentaria. La búsqueda de una identidad marcada se genera a partir de la reivindicación de técnicas textiles ancestrales, experimentación textil, sustentabilidad, slow fashion y upcycling, nacionalismo a flor de piel, funcionalidad de la mano con textiles inteligentes, entre otras tendencias en materia de diseño de indumentaria.
China: Hyper-Consumerism, Abstract Identity
Authors: Genevieve Cyr Marie
Published: September 2020

Es el siglo 21 el siglo chino? La occidentalización ha cambiado casi todas las facetas de la vida en China, a excepción de la política (Wu, 2009). Esto ha creado confusión masiva, entusiasmo, rebelión, romanticismo e idealismo. Las industrias manufactureras de la década de 1990 continuaron dominando la aceleración del consumismo en el siglo XXI y crearon, más que nunca, un mundo de identidad extrañamente gigante y abstracto que se auto creó y se mantuvo. Este artículo examina la política del deseo abstracto, el hiper consumismo y la noción de fantasía en la industria de la moda china. Hoy, cientos de “hipermercados” gigantes que se encuentran en toda China están dedicados a la distribución de “cosas” falsas. Estos emblemas comerciales se han convertido en una parte integral del paisaje visual y social de China. El mercado de productos falsificados que utilizan imágenes de marcas occidentales (ej., logotipos) ha crecido durante siglos hasta convertirse en una gran estructura abstracta de estilos de vida con marcas falsas y diseño integral. El aumento global del hiperconsumo le dio a China la última oportunidad de crear una nueva identidad para sí misma mientras se importa el sueño del lujo: The Buying Power. Este documento se centra en abstraer la noción de hiperconsumismo e interrogar la relación entre la publicidad visual, su materialidad y su representación en el mercado global. ¿Cómo contribuye la publicidad a la producción de bienes de consumo? ¿Podemos crear una visión cíclica de nuevos materiales? ¿Cómo se crea, se desplaza, se transforma y se consume el valor del lujo a través del espacio y el tiempo?
Perlindungan Kesehatan Masyarakat sebagai Justifikasi dari Tobacco Plain Packaging Act
Authors: Shalmont Jerry , Sugianto Richard Sebastian
Published: September 2020

 Abstract

Globalization and the rise of international trade of goods and services influence human health - can be both positive and negative. In order to strike a balance between trade and health, policy coherence at the country level is the key to achieve it. The first step towards policy coherence is the development of a good understanding of the issues, based on the analysis of the situation from both a health and trade perspective. This paper discusses on how to strike a balance between trade and health by referring to the latest plain packaging case which brought to WTO dispute settlement forum. After a long process, finally the Panel ruled in favor of the respondent, in this case Australia for their plain packaging policy. The Panel found that there is no alternative measure that can achieve the same objective – for public health which allows Australia to continue the implementation of their plain packaging policy. 

 

 Abstrak 

Globalisasi dan perkembangan perdagangan internasional pada barang maupun jasa mempengaruhi kesehatan manusia, dalam hal ini pengaruh dapat bersifat positif maupun negatif. Untuk dapat menyeimbangkan kepentingan perdagangan dan perlindungan kesehatan, koherensi kebijakan di tingkat negara memegang peranan yang penting. Langkah pertama dalam koherensi kebijakan ini dapat dimulai dengan adanya pemahaman yang baik terhadap isu terkait dengan didasarkan pada analisa situasi dari sisi perdagangan maupun kesehatan. Tulisan ini membahas tentang bagaimana menyeimbangkan kepentingan perdagangan dan kesehatan dengan mengacu pada studi kasus plain packaging yang dibawa pada sistem penyelesaian sengketa WTO. Setelah melewati proses yang panjang, akhirnya Panel WTO berpihak pada responden/pihak tergugat dalam kasus ini yaitu Australia. Panel menyatakan bahwa tidak ada kebijakan alternatif yang dapat diterapkan untuk dapat memenuhi tujuan yang sama, yakni perlindungan kesehatan masyarakat yang mana memperbolehkan Australia untuk tetap melanjutkan penerapan kebijakan plain packaging yang sudah dimulai sejak tahun 2012.
FUNGSI DAN WEWENANG DEWAN PERWAKILAN RAKYAT DAERAH PROVINSI BERDASARKAN AZAS OTONOMI DAERAH SELUAS-LUASNYA
Authors: Jahidin H. Jumahari
Published: September 2020

Menurut Pasal 315 Undang-Undang Nomor 17 Tahun 2014, DPRD Provinsi adalah lembaga perwakilan rakyat daerah yang berkedudukan sebagai unsur penyelenggara pemerintahan daerah Provinsi. DPRD Provinsi mempunyai 3 (tiga) macam fungsi, yakni (1) legislasi, (2) anggaran dan (3) pengawasan seperti diatur Pasal 316 Undang-Undang Nomor 17 Tahun 2014. Dalam rangka fungsi legislasi, DPRD Provinsi mempunyai salah satu wewenang dan tugas, yaitu membentuk peraturan daerah provinsi bersama dengan Gubernur, sebagaimana diatur Pasal 317 Undang-Undang Nomor 17 Tahun 2014. DPRD Provinsi adalah organ pemerintahan daerah bersama-sama dengan Gubernur membentuk Peraturan Daerah, diatur pada Pasal 57 UU Nomor 23 Tahun 2014. Tentang Pemerintahan daerah.  Perda Provinsi adalah landasan segenap tindakan Gubernur Kepala Daerah Provinsi dalam penyelenggaraan urusan pemerintahan. Berdasarkan “asas otonomi daerah yang seluas-luasnya” yang bertujuan untuk mendorong peningkatan kesejahteraan rakyat daerah. Akan tetapi, dalam konteks pembentukan Perda Provinsi, DPRD Provinsi belum dapat melaksanakan fungsi, wewenang dan tugas dalam pembentukan Perda Provinsi yang mendukung penyelenggaraan urusan pemerintahan secara maksimal. Pembentukan Perda Provinsi supaya dapat mendukung penyelenggaraan urusan pemerintahan, tidak boleh ditafsirkan secara bebas tanpa batas, sehingga bertentangan dengan (1) konsepsi bentuk Negara kesatuan, (2) sifat-hakikat asas desentralisasi, (3) tidak menyimpang dari fungsi, wewenang dan tugas DPRD Provinsi untuk menunjang Gubernur dan (4) materi-muatan Perda Provinsi tidak boleh bertentangan dengan peraturan perundang-undangan yang lebih tinggi. Pembentukan Perda DPRD Provinsi bersama Gubernur Provinsi dengan tujuan supaya penyelenggaraan urusan Pemerintahan dapat mendorong peningkatan kesejahteraan rakyat daerah.
URGENSI PERLINDUNGAN HUKUM BAGI KONSUMEN TOKO ONLINE DI MEDIA SOSIAL
Authors: Natalia Reggiannie Christy
Published: September 2020

E-commerce Indonesia telah berkembang dengan sangat pesat dan hadir dalam berbagai model bisnis. Salah satu jenis e-commerce yang masih sulit terjamah oleh hukum adalah klasifikasi bisnis toko online di media sosial. Apalagi, sampai sekarang Indonesia belum memilik suatu perundang-undangan yang secara khusus mengatur tentang e-commerce. Ketika terjadi pelanggaran dalam transaksi online, maka para konsumen harus mencari perlindungan dari peraturan yang berbeda-beda. Selain itu, walaupun perundang-undangan tersebut dapat menjadi dasar bagi kerugian yang timbul dalam e-commerce, namun dengan kerumitan dalam penyelesaian sengketa yang ada cenderung membuat kehadiran mereka kurang efektif bagi para konsumen. Oleh karena itu, penelitian ini bertujuan untuk menganalisa perlindungan hukum apa saja yang sudah tersedia dan peraturan apa yang harus ditingkatkan untuk menjawab urgensi perlindungan hukum bagi konsumen toko online di media sosial.

 
PERKEMBANGAN BENTUK PERTANGGUNGJAWABAN KORPORASI DALAM TINDAK PIDANA KORPORASI
Authors: Pangaribuan Togi
Published: September 2020

Pembangunan nasional Indonesia yang pesat berpengaruh pula terhadap pertumbuhan ekonomi yang semakin baik. Hal ini tentu tidak terlepas dari keberadaan korporasi sebagai pelaku bisnis dan usaha yang turut menyumbangkan pendapatan bagi negara baik secara langsung maupun tidak langsung, misalnya melalui penyediaan lapangan pekerjaan atau pembayaran pajak. Kehadiran korporasi yang terus berkembang baik dari segi jumlah maupun jenis dan lingkup usaha dan bisnisnya tentu menimbulkan persaingan yang semakin ketat. Dalam keadaan ini, timbul kesadaran bahwa ada kemungkinan praktek bisnis korporasi dilakukan dengan melakukan pelanggaran hukum, termasuk hukum pidana. Oleh sebab itu, hukum dan peraturan perundang-undangan juga dituntut untuk berkembang untuk menghindari kemungkinan tersebut, salah satunya dengan melihat korporasi sebagai suatu subyek hukum yang dapat dimintai pertanggungjawaban, termasuk pertanggungjawaban pidana.
Prevention of Unintended Appearance in Photos Based on Human Behaviors Analysis
Authors: Kaihoko Yuhi , Tan Phan Xuan , Kamioka Eiji
Published: September 2020

Nowadays, with smartphones people can easily take photos, post photos to any social networks and use the photos for some purposes. This leads to a social problem that unintended appearance in photos may threaten the privacy of photographed person. Some solutions to protect facial privacy in photos have already been proposed. However, most of them rely on different techniques to de-identify photos which can be done only by photographers, giving no choice to photographed person. To deal with that, we propose an approach that allows photographed person to proactively detect whether someone is intentionally/unintentionally trying to take pictures of him/her. Thereby, he/she can have appropriate reaction to protect the privacy. In this approach, we assume that the photographed person uses a wearable camera to record the surrounding environment in real-time. The skeleton information of likely photographers who are captured in the monitoring video is then extracted to be put into the calculation of dynamic programming score which is eventually compared with a threshold for recognition of photo-taking behavior. Experimental results demonstrate that by using the proposed approach, the photo-taking behavior is precisely recognized with high accuracy of 92.5%.
On The Symmetry of The Universe
Authors: Roza Engel
Published: September 2020

It is shown that the Lambda component in the cosmological Lambda-CDM model can be conceived as vacuum energy, consisting of gravitational particles subject to Heisenberg’s energy-time uncertainty. These particles can be modelled as elementary polarisable Dirac-type dipoles (“darks”) in a fluidal space at thermodynamic equilibrium, with spins that are subject to the Bekenstein-Hawking entropy. Around the baryonic kernels, uniformly distributed in the universe, the spins are polarized, thereby invoking an increase of the effective gravitational strength of the kernels. It explains the dark matter effect to the extent that the numerical value of Milgrom’s acceleration constant can be assessed by theory. Non-polarized vacuum particles beyond the baryonic kernels compose the dark energy. The result is a quantum mechanical interpretation of gravity in terms of quantitatively established shares in baryonic matter, dark matter and dark energy, which correspond with the values of the Lambda-CDM model..
Predictors of Death Rate During the COVID-19 Pandemic
Authors: Feinhandler Ian , Cilento Benjamin , Beauvais Brad , Harrop Jordan , Fulton Lawrence
Published: September 2020

COVID-19 is a potentially fatal viral infection. This study investigates geography, demography, socioeconomics, health conditions, hospital characteristics, and politics as potential explanatory variables for death rates at the state and county levels. Data from the Centers for Disease Control and Prevention, the Census Bureau, Centers for Medicare and Medicaid, Definitive Healthcare, and USAfacts.org were used to evaluate regression models. Yearly pneumonia and flu death rates (state level, 2014-2018) were evaluated as a function of the governors’ political party using repeated measures analysis. At the state and county level, spatial regression models were evaluated. At the county level, we discovered a statistically significant model that included geography, population density, racial and ethnic status, three health status variables along with a political factor. State level analysis identified health status, minority status, and the interaction between governors’ parties and health status as important variables. The political factor, however, did not appear in a subsequent analysis of 2014-2018 pneumonia and flu death rates. The pathogenesis of COVID-19 has greater and disproportionate effect within racial and ethnic minority groups, and the political influence on the reporting of COVID-19 mortality was statistically relevant at the county level and as an interaction term only at the state level.
Susceptibility of Blood Orange Cultivars to Chilling Injury Based on Antioxidant System, Physiological and Biochemical Responses at Different Storage Temperatures
Authors: Habibi Fariborz , Ramezanian Asghar , Guillén Fabian , Martínez-Romero Domingo , Serrano María , Valero Daniel
Published: September 2020

Susceptibility of four blood orange cultivars (‘Moro’, ‘Tarocco’, ‘Sanguinello’ and ‘Sanguine’) to chilling injury (CI) was studied. Antioxidant enzymes, physiological and biochemical changes were measured monthly at 2 and 5 °C plus 2 days at 20 °C for shelf life. At 2 °C, CI symptoms were higher than at 5 °C, and ‘Moro’ and ‘Tarocco’ had significantly higher CI than ‘Sanguinello’ and ‘Sanguine’. ‘Moro’ and ‘Tarocco’ had the highest electrolyte leakage, malondialdehyde, H2O2 and polyphenol oxidase activity and lower phenylalanine ammonia-lyase compared with ‘Sanguinello’ and ‘Sanguine’. The scanning electron microscopy micrographs revealed that ‘Moro’ and ‘Taroco’ showed severe fractures in the flavedo due to CI. ‘Sanguinello’ and ‘Sanguine’ were more tolerant to CI due to an increase of catalase, ascorbate peroxidase and superoxide dismutase, which could prevent the loss of membrane integrity and alleviate CI symptoms. The order of susceptibility of cultivars to CI was ‘Moro’> ‘Tarocco’> ‘Sanguine’> ‘Sanguinello’.
Truffle Species Strongly Shapes Its Surrounding Soil Mycobiota in A Pinus armandii Forest
Authors: Liu Dong , Herrera Mariana , He Xinhua , Perez-Moreno Jesús , Yu Fuqiang
Published: September 2020

Truffles contribute to crucial dynamics in the soil systems, being involved in plentiful ecological functions important for ecosystems. Despite this, the interactions between truffles and surrounding mycobiota remain unknown. Here, we aimed to shed light on how much truffle species could affect its surrounding soil mycobiota. Using traditional chemical analysis and Illumina ITS amplicon sequencing, we compared soil nutrients and mycobiota surrounding two truffle species: Tuber indicum (Ti) and T. pseudohimalayense (Tp) inhabit in the same Pinus armandii forest in southwestern China. Tp soil was more acidic and had higher nutrients (total C, N, P contents) than Ti soil. Fungal richness and diversity of truffle ascomata and surrounding soils were significantly higher in Tp than in Ti. Redundancy analysis showed relationships between soil fungal taxa and soil properties had changed from negative (Tp) to positive (Ti) and shifted from a moisture-driving (Tp) to a total N-driving (Ti). Overall, our results showed that the interactions between truffle and soil system had been altered with species variation, although the causative peculiarity of these associations needs to be further studied.
A Study on The Influence of Chemical Nature of Fillers on Rheological and Fatigue Behaviour of Bitumen Emulsion Mastic
Authors: Al-Mohammedawi Ahmed , Mollenhauer Konrad
Published: September 2020

Recently Cold Bitumen Emulsion (CBE) mixture technologies have been developed to lower the pavement construction temperatures to reduce the environmental costs and control the gas emissions. Due to its poor early mechanical strength, active fillers (i.e. cement) have been used to obtain high early stiffness in order to have the potential for timely construction of the next layer. There is, however, a lack of understanding about the impact of active fillers nature on viscoelastic behaviour and fatigue damage resistance of CBE mastics. This study, therefore, aims to identify the influence of active fillers on the rheological properties and the resulted fatigue behaviour of CBE mastic, supported by chemical analysis for the filler-bitumen emulsion. For this aim, bitumen emulsion was mixed separately with seven fillers/blended fillers to prepare the CBE mastics. Various experiments include continuous pH monitoring tests (chemical reactivity of filler-bitumen emulsion), Strain sweep (SS) tests, Temperature-Frequency Sweep (TFS) tests, Time Sweep (TS) tests, and Linear Amplitude Sweep (LAS) tests were conducted on the CBE binder and the prepared mastics. Results show that the rheological performance and the fatigue damage resistance is not only dependent on the filler inclusions, but it significantly relies on filler type and chemistry. Based on that, the raise in complex shear modulus and the decrease in viscous components were associated with a significant enhancement in fatigue performance for specific filler.
Existence, Uniqueness and Input-To-State Stability of Ground-State Stationary Strong Solution of a Single-Species Model via Mountain Pass Lemma
Authors: Rao Ruofeng
Published: September 2020

In this paper, the authors employ Mountain Pass Lemma, the method of weak solution regularization and Lyapunov function method to derive the unique existence of globally exponential stable positive stationary solution of a single-species model with diffusion and delayed feedback. The obtained stability criterion illuminates that under some suitable conditions, a certain internal competition is conducive to the overall stability of the population, and a certain amount of family planning is conducive to the overall stability of the population. A numerical example and three tables show the effectiveness of the proposed methods.
Effect of Diuron on Embryo-Larval Development of Javanese Medaka (Oryzias javanicus, Bleeker 1854)
Authors: Ibrahim Musa Adamu , Zulkifli Syaizwan Zahmir , Azmai Mohammad Noor Amal , Mohamat-Yusuff Ferdaus , Ismail Ahmad
Published: September 2020

Some herbicides exert hormetic or biphasic non-monotonic dose-response (NMDR), which is one of the major challenges for ecological risk assessment (ERA) of pesticides pollution. In this study, fish embryo toxicity test (FET) with Javanese medaka (Oryzias javanicus) to sublethal concentration of diuron was determined. Inverted U-shape heart rate was observed at 3 days post-exposure (dpe) and 7 dpe. However, at 13 dpe the heart rate (104 ± 2.90 heartbeat/min.) decreased in 10.00 mg.L-1 exposed-embryos. At 20 dpe, hatchability and survival rate were reduced in 5.00 mg.L-1 and 10.00 mg.L-1 exposed groups. Hormetic developmental deformities were observed in embryo-larvae of Javanese medaka. The results revealed a biphasic effect of low concentrations of diuron on some morphological and physiological features of Javanese medaka embryo-larvae, which might be attributed to endocrine disruption of this herbicide. Further studies to support these effects were recommended.
Recent Advances on Properties and Utility of Nanomaterials Generated from Industrial and Biological Activities
Authors: Yadav Virendra , Malik Parth , Pandit Priti , Khan Samreen Heena , Suriyaprabha R. , Choudhary Nisha
Published: September 2020

Today is the era of nanoscience and nanotechnology, which finds applications in the field of medicine, electronics, or environmental cleanup. Even though the nanotechnology is in its emerging phase, but still it provides solutions to numerous challenges. Nanotechnology and nanoparticles are found very effective because of their unique chemical and physical properties, high surface area, but their high cost is one of the major hurdles in its wider application. So, the synthesis of nanomaterials especially 2D nanomaterials from the industrial, agricultural and other biological activities could provide a cost-effective technique. The nanomaterials synthesized from such waste not only minimizes the pollution but also provides an eco-friendly approach towards the utilization of the waste. In the present review work, the emphasis has been given on the types of nanomaterials, different methods for the synthesis of 2D nanomaterials from the waste generated from industries, agriculture and their application in electronics, medicine and catalysis.
Bioactive Compounds from Monotheca Buxifolia Inhibit the Growth of Hepatocellular Carcinoma Cells
Authors: Hassan Said , Rehman Ashfaq , Jamal Syed Babar , Liu Yaqin , Lu Shaoyong
Published: September 2020

The natural products and conventional chemotherapeutic drugs are believed to increase the cure rates of anti-cancer treatment while reducing their toxicity. The current study investigates the cytotoxic and apoptogenic effects of bioactive compounds from Monotheca buxifolia on Hep G2 cell lines. The effect on the viability of Hep G2 cells was evaluated by MTT assay; Morphological changes were studied, the apoptotic activity was demonstrated through Annexin-V-FITC/ PI, a molecular dynamics simulation study was conducted to explore the binding pattern of the compounds in the active site of the PPRAδ protein. The isolated compounds lauric acid, oleanolic acid, and bis(2-ethylhexyl) phthalate inhibited the growth of hepatocellular cancer cells, as determined by MTT assay and annexin V-FITC/PI. The IC50 value for lauric acid was 56.4584 ± 1.20 µg/ml, that for oleanolic acid was 31.9421 ± 1.03 µg/ml, and that for bis(2-ethylhexyl) phthalate was 83.8019 ± 2.18 µg/ml. After 24 h of treatment, 29.5% of Hep G2 cells treated with lauric acid, 52.1% of those treated with oleanolic acid, and 22.4% of those treated with bis(2-ethylhexyl) phthalate were apoptotic. Morphological assay and Hoechst staining microscopy revealed the morphological alterations of cell membrane accompanied by nuclear condensation after treatment. The high fluctuation indicates the high potency and adopting various interactions, and vice versa, the oleanolic acid showed highly residues fluctuation, which remains stable in the active site of PPARδ protein and involved in various interactions while remaining locally fluctuated in the binding site the other two compounds. In conclusion, a significant apoptogenic effect was exhibited by lauric acid, oleanolic acid, and bis(2-ethylhexyl) phthalate against HepG2 cells in inducing apoptosis. Our findings indicate that these bioactive compounds hold promise as potential therapeutic for hepatocellular carcinoma.
A Study on Thermal and Electrical Conductivities of Ethylene-Butene Copolymer Composites with Carbon Fibers
Authors: Hamid Yasin , Svoboda Petr , Svobodová Dagmar
Published: September 2020

The electrical, mechanical and thermal conductivity of ethylene butene copolymer (EBC) composites with carbon fibers were studied. EBC/carbon-fiber composites can be utilized as an electro-mechanical material which is capable of changing it electric resistance with mechanical strain. Carbon fibers were introduced to EBC with different concentrations (5-25 wt%). The results showed that the addition of carbon fibers to EBC could increase the electric resistance up to 10 times. Increasing the load to 2.9 MPa could increase the electric resistance change by 4500% compared 25% fiber sample with pure EBC. It is also noted that the electric resistance of the EBC/CF composites underwent a dramatic increase with raising the strain, for example, the resistance change was around 13 times more at 15% strain in comparison to 5% of strain; The thermal conductivity tests showed that the addition of carbon fibers could increase the thermal conductivity by 40%, from 0.19 to 0.27 (Wm-1K-1). It was also observed that the addition of carbon fibers to EBC could increase the thermal conductivity.
Influences on Attitudes regarding Potential COVID-19 Vaccination in the United States
Authors: Pogue Kendall , Jensen Jamie , Stancil Carter , Ferguson Daniel , Hughes Savannah , Mello Emily , Burgess Ryan , Berges Bradford , Quaye Abraham , Poole Brian D.
Published: September 2020

The COVID-19 pandemic continues to ravage the world, with the United States being highly affected. A vaccine provides the best hope for a permanent solution to controlling the pandemic. However, to be effective, a vaccine must be accepted and used by a large majority of the population. Structural equation modelling was used to analyze the relationships of several factors with attitudes toward potential COVID-19 vaccination. The survey was administered to 316 respondents across the United States by a survey corporation. Prior vaccine usage and attitudes predicted attitudes towards COVID-19 vaccination. Assessment of the severity of COVID-19 for the United States was also predictive. Approximately 68% of all respondents were supportive of being vaccinated for COVID-19, but side effects, efficacy, and length of testing remained concerns. Longer testing, increased efficacy and development in the United States were significantly associated with increased vaccine acceptance. Messages promoting COVID-19 vaccination should seek to alleviate the concerns of those who are already vaccine-hesitant. Messaging directed at the benefits of vaccination for the United States as a country would address the second predictive factor. Enough time should be taken to allay concerns about both short and long-term side effects before a vaccine is released.
Polyporus polysaccharide regulates proliferation, apoptosis and migration of bladder cancer cells by polarizing macrophages to M1 subtype in tumor microenvironment
Authors: Jia Wenyu , Luo Siwan , Lai Gena , Li Shiqi , Huo Shuai , Li Meifang , Li Xiong , Liu Chunping , Zeng Xing
Published: September 2020

Background Polyporus polysaccharide (PPS), an active ingredient of traditional Chinese medicinal Polyporus umbellatus, has multiple biological functions, such as anti-cancer, immune-regulating and hepatoprotective activities. The purpose of this study was to investigate the mechanism of PPS activated macrophages in the treatment of bladder cancer.Methods 100 ng/mL Phorbol myristate acetate (PMA) was used to induce THP-1 human leukemic cells as a macrophage model. Flow cytometry was used to detect the expression of CD14 and CD68 to verify the establishment of macrophage model. After that, Macrophages derived from THP-1 were treated with different concentrations of PPS (1,10 and 100 ug/mL). Flow cytometry and RT-PCR were used to detected the expression of CD16, CD23, CD86, CD40 and interleukin (IL)-Iβ, iNOS mRNA. ELISA was used to test the change of IL-1β and TNF-α in macrophage after the treatment with PPS. The conditioned medium from PPS-polarized macrophages was used to detect the effect of activated macrophages on bladder cancer. MTT assay, 5-ethynyl-2¢-deoxyuridine assay, flow cytometry, Transwell assay, and Western blot analysis were used to detect the effects of polarized macrophages on the viability, proliferation, apoptosis, and migration of bladder cancer cells. Western blot was also used to analysis the change of JAK2/NF-κB pathway protein.Results PPS promoted the expression of pro-inflammatory factors, such as IL-Iβ, TNF-α and iNOS, and surface molecules CD86, CD16, CD23, and CD40 in macrophages and then polarized macrophages to M1 type. The results demonstrated that activated macrophages inhibited the proliferation of bladder cancer cells, regulated their apoptosis, and inhibited migration and epithelial–mesenchymal transformation (EMT). JAK2/NF-κB pathways were downregulated in the anti-bladder cancer process of activated macrophages. Conclusion The findings indicated that PPS inhibited the proliferation and progression of bladder cancer by the polarization of macrophages to M1 type, and JAK2/NF-κB pathway was downregulated in the process of anti-bladder cancer.
Co-production as a co-creation or co-destruction process? An internal evaluation of a co- production exercise with family caregivers living in a rural and remote area  
Authors: Gheduzzi Eleonora , Masella Cristina , Morelli Niccolò , Graffigna Guendalina
Published: September 2020

Background: Co-production has been widely recognized as a plausible means to reduce the dissatisfaction of service users, the inefficacy of service providers, and conflicts in relations between the former and the latter. However, this enhancement of co-production has started to be questioned: co-production is not always a panacea, and its effects may not always be fruitful. To understand and prevent unsuccessful user and provider collaboration, the recent literature has begun to focus on the causes of co-destruction. This paper investigates how the possible limiting factors that arose during the co-production of a new social service with family caregivers of older patients living in a rural and remote area might influence the process of co-creation and/or co-destruction. Methods: To investigate this topic, we performed a single case study by considering a longitudinal project (Place4Carers) intended to co-produce a new social care service with and for the family caregivers of elderly patients living in a rural and remote area. We organised collaborative co-assessment workshops and semi-structured interviews to collect the views of family caregivers and service providers on the co-production process. As part of the research team that participated in the co-production process, we contributed to the analysis with a reflexive approach. Results: The results confirmed that the project experienced both the processes of co-creation and co-destruction. Some dimensions are crucial in such processes. In particular, the dimension related to trust in the promoter of a project and the other partners can determine its success or failure. Moreover, the level and effectiveness of engagement and creating a cohesive partnership among partners are key aspects for a co-creative project. Conclusions: Our article confirms that the co-creation and co-destruction processes coexist. The role of researchers and service providers is to prevent or remedy co-destruction effects. To this end, we suggest that in co-creative projects more time should be spent on creating mutual trust through conviviality among participants, and institutions should foster collaborative research in order to help organizations that are not used to working together. Hence, particular attention should be paid to internal evaluative procedures.
Network analysis of firearm movement among US states
Authors: Takada Sae , Choi Kristen , Natsui Shaw , Saadi Altaf , Buchbinder Liza , Easterlin Molly , Zimmerman Frederick
Published: September 2020

Background: The movement of firearm across state lines may decrease the effectiveness of state-level firearm laws. Yet how state-level firearm policies affect cross-state movement have not yet been widely explored. This study aims to characterize the interstate movement of firearms and its relationship with state-level firearm policies. Methods : Cross-sectional time series network analysis of interstate firearm movement using Bureau of Alcohol, Tobacco, Firearms, and Explosives firearm trace data (2010 -2017). We constructed the network of firearm movement between 50 states. We used zero-inflated negative binomial regression to estimate the relationship between the number of a state’s firearm laws and number of states for which it was the source of 100 or more firearms, adjusting for state characteristics. We used a similar model to examine the relationship between firearm laws and the number of states for which a given state was the destination of 100 or more firearms. Results : Over the 8-year period, states had an average of 26 (SD 25.2) firearm laws. On average, a state was the source of 100 or more crime-related firearms for 2.2 (SD 2.7) states and was the destination of 100 or more crime-related firearms for 2.2 (SD 3.4) states. Greater number of firearm laws was associated with states being the source of 100 or more firearms to fewer states (IRR0.67 per SD, p<0.001), higher odds of not being a source to any states (aOR1.56 per SD, p<0.001), and states being the destination of 100 or more firearms from more states (IRR1.83 per SD, p<0.001). Conclusions: Restrictive firearm policies are associated with less movement of firearms to other states, but with more movement of firearms from outside states. The effectiveness of state-level firearm-restricting laws is complicated by a network of interstate firearm movement.
Life Satisfaction among a Clinical Eating Disorder Population
Authors: Claydon Elizabeth , DeFazio Caterina , Lilly Christa L. , Zullig Keith J.
Published: September 2020

Background:The primary objective was to understand life satisfaction (LS) of patients with eating disorders (EDs) in relation to eating pathology severity, personal/familial ED history, and key demographic and anthropometric variables.Methods:Participants (N=60) completed the Satisfaction with Life Scale (SWLS), the Eating Pathology Severity Index (EPSI), and demographic questionnaires. Bivariate associations via correlations and multiple linear regression models were used to explore these relationships.Results:The SWLS mean score was 3.7 out of 7, suggesting it is below the population-based norm. LS was positively statistically significantly associated with private insurance, past ED, EPSI muscle building, EPSI restricted eating, and EPSI negative attitudes. When included in multiple linear regression, the model explained 33% of the variability of LS [F (7, 56) = 3.4, p = 0.0054, R 2 = 0.33]. EPSI muscle building remained the strongest predictor (β = 0.13, p = 0.04).Conclusions:Based on the data, individuals who have/have had EDs scored lower on the SWLS than the general population. Individuals scoring within this range typically experience significant issues in several areas of life or a substantial issue in one area.
Therapeutic activity of sarpogrelate, and dopamine D2 receptor agonists on cardiovascular and renal systems in alloxan-induced diabetic rats
Authors: Fouad Mohamed , Latif Hekma A. Abd El , Galal May , Yamani Mohammed El , Hassaneen Sherifa , Masoaad Raneem
Published: September 2020

Background: The investigation aims to represent the activity of sarpogrelate, a particular 5-HT (2A) receptor blocker, in reducing myocardial injury prompted by extended haul utilization of D2 agonist drugs in diabetic rats. Dopamine D2 agonists are notable medications in the treatment of Parkinsonism, hyperprolactinemia, and hyperglycemia. An affiliation showed between the enlistment of myocardial injury ailment and long term treatment with dopamine D2 agonist drugs identified with the partial initiation of 5-HT 2a receptors. Methods: Both bromocriptine and cabergoline were managed independently and combined with sarpogelate for about a month to diabetic nephropathy rats. Both tail-cuff blood pressure and BGL were recorded weekly. For all animals, kidney hypertrophy index, serum creatinine, blood urea nitrogen, alanine transaminase, and aspartate transaminase levels were measured after one month of treatment. The severity of the cardiac injury was assessed by the estimation of LDH-1, cardiac troponin I, and TNFα. Triphenyl tetrazolium chloride staining method used to determine experimental myocardial infarction (MI) size. Results: Bromocriptine and cabergoline created a significant reduction in BGL, BP, and kidney hypertrophy index in diabetic nephropathy rats. Administration of bromocriptine, cabergoline, alone, or in combination with sarbogrelate fundamentally diminished blood concentrations of ALP, AST, urea, and creatinine. Bromocriptine and cabergoline alone showed noteworthy ascending of LDH-1, Troponin I, and TNFα1 levels in the serum (p<0.05). Paradoxically, utilizing bromocriptine and cabergoline with sarpogrelate treatment altogether diminished the degree of the myocardial biomarkers in the serum. A mix of bromocriptine or cabergoline with sarpogrelate diminished the level of the myocardial infarct size in the heart assessed utilizing the TTC staining method. Conclusions: The examination exhibited that both bromocriptine and cabergoline could be utilized safely in blend with sarpogrelate for a long duration of treatment for diseases like hypertension and diabetes.
Predicting Prevention of Cigarette Smoking in Youth: Using Multi-Theory Model (MTM)
Authors: Abasi Hamid , Asadi Zahra Sadat , Mezerji Naser Mohammad gholi
Published: September 2020

The authors have withdrawn this preprint due to erroneous posting.
Swi6/HP1 binding to RNA-DNA hybrids initiates heterochromatin assembly
Authors: Singh Jagmohan , Kumar Jyotsna , Haldar Swati , Gupta Neelima , Kumar Viney , Thakur Manisha , Chandradoss Keerthivasan , Ghose Debarghya , Dutta Dipak , Sandhu Kuljeet
Published: September 2020

Heterochromatin formation in fission yeast and metazoans involves di/trimethylation of histone H3 at lysine 9 position (me2/me3-K9-H3) by the histone methyltransferase (HMT) Suv39/Clr4, followed by binding of Swi6/HP1 to me2/me3-K9-H3 via its chromodomain1. Subsequent self-association of Swi6/HP1 on adjacent nucleosomes leads to folded heterochromatin structure1-3. An alternate model suggests a concerted participation of Clr4 and Swi6/HP12,3. HP1 binding to RNA has been invoked for heterochromatin silencing in metazoans4,5. Swi6/HP1 also binds and channels RNA to exosome pathway in fission yeast6. Recruitment of Swi6/HP1 to centromere is also dependent on the RNAi pathway7. Here we show that Swi6/HP1 exhibits binding to RNAs, ranging from promiscuous, low-affinity binding to mRNAs, to moderate-affinity binding to the RNAi-generated siRNAs corresponding to the repeats present in heterochromatin regions7, to high affinity binding to the RNA-DNA hybrids cognate to the repeats. Together with sensitivity of Swi6 localization and silencing to RNaseH, our results suggest a dynamic distribution of Swi6/HP1 among the heterochromatin and euchromatic transcripts and binding to RNA-DNA hybrid as an RNAi-dependent and Me2/me3-K9-H3-independent mechanism of recruitment, leading to heterochromatin formation and silencing.