bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of assessing the intestinal barrier permeability in chronic kidney disease
Authors: Pyatchenkov M. O. , Vlasov A. A. , Sherbakov E. V. , Belskykh A. N. , Kryukov E. V. , Markov A. G.
Published: January 2023

Numerous studies have shown that changes in the intestinal microbial-tissue complex are a risk factor for the progression of chronic kidney disease (CKD) to end-stage renal disease and, therefore, a potential target for new therapeutic interventions. Thus, reliable and sensitive diagnostic tools for measuring intestinal permeability in the clinical setting are necessary. Modern genome sequencing and multi-omics technologies have established that patients with CKD are characterized by a specific imbalance between the saccharolytic and proteolytic microbiota, contributing to the accumulation of numerous toxic microbial products, such as indoxyl sulphate, p-cresyl sulphate, trimethylamine-N-oxide. Progressive kidney function decline leads to compensatory urea accumulation in the gastrointestinal tract. In the intestinal lumen, urea is hydrolyzed by microbial urease, forming a large amount of ammonium hydroxide, which may be accompanied by disruption of the epithelial barrier integrity with an increase in intestinal permeability for microbial molecules that initiate systemic inflammation. Experimental approaches to studying the intestinal barrier in CKD include the assessment of electrophysiological parameters of the intestinal epithelium and the transport of fluorescently labelled tracers in the Ussing chamber. Actively improving various cell-based in vitro methods, which may be useful for studying the effect of microbiota on the barrier functions of the intestinal epithelium. Gene expression and protein content of tight junctions are estimated using polymerase chain reaction, immunohistochemical methods and Western blotting. Using various biomolecular methods, it was found that renal failure is characterized by the presence of inflammatory and atrophic changes throughout the gastrointestinal tract, destruction of the mucin layer, damage to tight junctions with a decrease in the amount of claudine-1, occludin and ZO-1 as well as a decrease in transepithelial electrical resistance. Clinical examination of intestinal permeability by methods based on the urine excretion of orally administered sugars, polyethylene glycol polymers and labelled tracers indicate a distortion of the results in patients with CKD due to altered renal clearance. Alternatively, quantitative determination of bacterial DNA and D-lactate levels in the blood is considered. Identification of serum non-coding microRNAs, confocal laser endomicroscopy and impedance spectroscopy have the potential to be used as methods for assessing intestinal barrier function.
Axis “microbiota - muscle”
Authors: Zavyalova A. N. , Novikova V. P. , Ignatova P. D.
Published: January 2023

The luminal intestinal microflora affects the state of the muscular system of experimental animals and humans. The role of nutrition in the development of skeletal muscles is considered. The role of metabolically active substances secreted by the microbiota in the development of cachexia, sarcopenia, and kwashiorkor is considered. The effect of exercise on the gut microbiome was assessed. Possible variants of the influence of probiotics on the state of skeletal muscles and its functional activity in the experiment in animals and humans are presented.
Microbiome changes in acne patients with celiac disease under different treatments
Authors: Ledentsova S. S. , Gulyaev N. I. , Oreshko L. S. , Seliverstov P. V.
Published: January 2023

Introduction. Systemic retinoids with a hepatotoxic effect and antibiotics affecting intestinal microflora are the first-line drugs in the treatment of moderate and severe acne. To prevent complications, it is necessary to search, develop and introduce into practice safe drug combinations, including drugs with a protective effect on intestinal microflora and liver. Objective. To study the effect of psyllium on tolerance and efficacy of systemic therapy with isotretinoin and doxycycline in patients with moderate acne having celiac disease. Material and methods. We examined 83 patients with celiac disease having moderate acne. They were randomized into two groups: group 1, receiving antibiotics (doxycycline), and group 2, receiving retinoid system (isotretinoin). Each group was divided into two subgroups A and B, depending on the reception of psyllium. Patients were followed up for 4 and 24 weeks, respectively. All patients received adjuvant topical therapy. Medical check-ups, biochemical blood and bacteriological stool analysis were done in each group before treatment and after the treatment. Results. In subgroup 1B (received psyllium) significant changes of intestinal microbiota were not observed during antibiotic treatment, in contrast to subgroup 1А, where severe intestinal dysbiosis was found. In subgroup 2A (without psyllium) carbohydrate metabolism disorder and lipid storage disease were noted on isotretinoin treatment, not being observed in subgroup 2B. Conclusion. Patients in both subgroups, who in addition to antibiotic and systemic retinoid treatment, received psyllium, showed better results of skin health, intestinal microbiome, general well-being, and quality of life.
The features of the flow and possible mechanisms development of gastroesophageal reflux disease in chronic duodenal insufficiency
Authors: Vakhrushev Ya. M. , Busygina M. S. , Butorina N. V.
Published: January 2023

Target. Evaluation of the role of chronic duodenal insufficiency (CDN) in the development of gastroesophageal reflux disease (GERD). Materials and methods. The study included 42 patients with GERD. In 23 patients, GERD was combined with CRF (observation group) and 19 patients had GERD without CRF (comparison group). The control group consisted of 30 healthy individuals. In the examination of patients, in addition to the study of anamnestic and physical data, the results of the study of hormones (gastrin, insulin, cortisol, somatostatin) and power acids of the parietal mucus of the esophagus were used. Instrumental research methods are represented by intragastric pH-metry with the help of “Gastroscan-5M”, gastroenteromonitoring “Gastroscan-GEM”, cavity manometry using the Waldman apparatus. The results obtained were analyzed on a personal computer using the Excel®2016 spreadsheet analysis package, IBM SPSS v. Results. The study found that the majority of patients with chronic duodenal insufficiency and gastroesophageal reflux disease noted pain in the epigastric region (16 (69.6%)) and behind the sternum (19 (82.6%)) and bitter belching 14 (60.8%). In patients in the comparison group, heartburn prevailed (15 (78.9%)) against the background of mild pain syndrome 8 (42.1%) (p=0.021). The coefficient of duodenal contraction rhythm in patients of the observation group (2.4±0.37) was significantly higher than in the comparison group (0.7±0.18, p=0.021). The acidification of the intraduodenal environment is indicated by the pH of the duodenal bulb (5.5±0.74). The content of hormones in the peripheral blood in GERD with chronic renal failure is represented by a reduced content of insulin and somatostatin and an increase in cortisol and gastrin in comparison with indicators in GERD and healthy individuals. Conclusion. The results of the research allowed to expand the understanding of the mechanisms of development of GERD in chronic renal failure and demonstrate that they include not only “aggressive” refluxants, but are also associated with changes in neurohormonal control systems.
Filsafat hukum menjadi corak ilmu hukum
Authors: Yeni Fitri
Published: January 2023

Filsafat dan hukum sebagaimana di atas, maka menarik kemudian untuk menganalisis bagaimana filsafat dan hukum bersinergi sehingga menghasilkan filsafat hukum. Dalam beberapa literatur filsafat hukum digambarkan sebagai suatu disiplin modern yang memiliki tugas untuk menganalisis konsep-konsep Perskriptif yang berkaitan dengan yurisprudensi. Istilah filsafat hukum Memiliki sinonim dengan legal philosophy, philosophy of law, atau rechts Filosofie. Pengertian filsafat hukum pun ada berbagai pendapat. Ada yang Mengatakan bahwa filsafat hukum adalah ilmu, ada yang mengatakan Filsafat teoretis, ada yang berpendapat sebagai filsafat terapan dan Filsafat praktis, ada yang mengatakan sebagai subspesies dari filsafat Etika, dan lain sebagainya.
Catatan Perkuliahan Business Plan
Authors: Angelina Chelsea Putri
Published: January 2023

Ringkasan eksekutif merupakan hal terpenting di dalam suatu bisnis. Ringkasan ini digunakan untuk menarik para pembaca dalam mencari tahu mengenai produk, pasar, maupun teknik yang digunakan dalam bisnis tersebut. Hal ini dapat mencerminkan hasil dari seluruh perencanaan dan harus dibuat hati-hati dengan mempertimbangkan semua aspek lain dari bisnis. Beberapa pemodal ventura lebih menyukai dalam menerima ringkasan dan keuangan saja sebelum meninjau keseluruhan rencana.
3D SEISMIC ANALYSIS OF CENOZOIC SLOPE DEPOSITS AND FLUID FLOW PHENOMENA ALONG THE NIGERIAN TRANSFORM MARGIN
Authors: Olobayo Oluwatobi , Huuse Mads
Published: January 2023

High-resolution 3D seismic data covering an area of 2,845 km2 provide new insights on slope deposits and fluid-flow phenomena along the Nigerian Transform Margin, focusing on the ~ 2 km thick Cenozoic post-transform succession. The study documents large-scale mass-transport complexes, deep-water channel complexes, sediment waves, and a wide range of fluid flow phenomena. The focused fluid flow phenomena include pockmarks, vertical pipes, seabed mounds and gas-hydrate related bottom simulating reflections. They are observed from Pliocene-aged sediments and distributed above structural highs, regional faults and active and relic deep-water channels in the eastern part of the study area, closest to the Niger Delta cone. The identified fluid flow features could be indicative of an active petroleum system in the deeper subsurface, and fluids could have migrated along planes of deep-seated, regional faults. The mass- transport deposits are mapped at multiple levels and the volume of failed sediments increased through time such that they constitute very significant portion of the entire stratigraphic succession (up to 25%) within the western part of the study area. The repeated and increased volume of mass transport deposit in the area is attributed to increased rate of sedimentation through time, slope gradient and probably increasing amplitude of sea level change during the late Cenozoic. The presence of repeated mass-transport deposits and fluid flow phenomena on the Nigeria Transform Margin has implications for installations of offshore facilities as they constitute potential geohazards. The study documents, for the first time, polygonal fault systems offshore Nigeria, adding to the global inventory of polygonally-faulted claystones, and suggesting a more oceanic dominated mudstone sedimentation than nearer the Niger Delta.
Clinico-epidemiological presentation of acute encephalitis syndrome in patients visiting a tertiary hospital in Kathmandu, Nepal: A descriptive cross-sectional study
Authors: Dhital Bidhi , Bhat Neeti
Published: January 2023

Introduction: Acute encephalitis syndrome is diagnosed when a person of any age, and at any time of the year, presents with the acute onset of fever and a change in mental status and/or new onset of seizures. It has an ill-defined clinico-epidemiological presentation in Nepal, making it a challenging medical condition. The objective of this study was to study the clinical profile of acute encephalitis syndrome.
Methods: All consecutive admissions at Tribhuvan University Teaching Hospital between April 2017 and December 2018 were screened for acute encephalitis syndrome. The diagnosis was confirmed by history, examination, laboratory findings, brain imaging, and electroencephalography. All patients who met the inclusion criteria were enrolled. For data entry and analysis, statistical package for the social sciences software version 16.0 was used. Descriptive statistics as frequencies and mean ± standard deviations were computed.
Results: The mean age of the study population was 49.56±22.28 years with male predominance 42(58.3%). Among the diagnosed etiologies, 1.38% had Japanese encephalitis, 4.12% had herpes encephalitis, and 4.12% had autoimmune encephalitis. Out of the 72 patients, 52 patients (72.22%) had Glasgow coma scale >12, 15 patients (20.83%) had 8 to 12, and five patients (6.94%) had coma (Glasgow coma scale <8). Among the clinical findings, altered mental status (91.66%) was the most commonly noticed manifestation followed by fever.
Conclusions: Most patients had altered sensorium with less severe brain injury based on the Glasgow coma scale score during the presentation. Its low diagnostic yield, however, often leads to an increase in unknown etiologies. The syndrome was more prevalent in hilly regions.
Feedback of the faculty participants on training workshop on developing multiple choice questions
Authors: Piryani Rano Mal , Piryani Sunee , Zeba Nudrat
Published: January 2023

Introduction: Multiple choice questions are commonly used tools for the written assessment of undergraduate health professions students. Faculty members need training for the development of valid and reliable multiple choice questions. For this purpose, Bilwal medical college organized one-day training workshop on developing multiple choice questions for newly recruited faculty members in March 2021. The main objective of the study was to assess the feedback of the participants on training workshop.
Methods: This descriptive cross-sectional study assessed the feedback of the participants of training workshop on developing multiple choice questions. The feedback questionnaire had four questions. First was on “rating training workshop on scale 1 to 10 (1=poor, 10=excellent) for usefulness, content, relevance, facilitation and overall”. Second was on confidence of the participants in developing MCQs after participation based on Likert scale 1 to 4 (1=not confident to 4=extremely confident). Third was on perceptions of the participants on strengths of training workshop. Lastly, fourth was on areas for improvement. The data was analyzed for central tendency using microsoft excel.
Results:  Participants’ feedback rating about usefulness (8.82±1.51), content (8.12±1.69), relevance (8.35±1.46), facilitation (8.41±1.46) and overall (global) rating (8.35±1.41) was remarkable. Their confidence level after participation (3.41±0.51) was noticeable.
Conclusions: The perceptions of the participants immediate after the training workshop i.e, their reaction was positive.
Multidrug resistant and extended spectrum β-lactamase producing gram negative bacterial uropathogens among females in a tertiary hospital, Pokhara
Authors: Pandey Raju , Bhattarai Samjhana , Subedi Binita , Paudel Rajan , Chapagain Bipin , Jaiswal Suresh , Tiwari Bishnu Raj
Published: January 2023

Introduction: Extended spectrum β-lactamase producing gram negative bacilli has emerged and spread worldwide as an important cause of urinary tract infections and indicates a major threat. The study aimed to determine the prevalence of multidrug resistant and extended spectrum beta-lactamase producing gram negative bacterial uropathogens among females in a tertiary level hospital.
Methods: A hospital-based cross-sectional study was conducted in Pokhara Academy of Health Sciences, Pokhara from February to November, 2019. A total number of 301 midstream urine samples were collected and examined using MacConkey agar and blood agar medium. Antimicrobial susceptibility testing was done by Kirby Bauer disk diffusion method on Mueller Hinton agar using Clinical and Laboratory Standards Institute guidelines.
Results: Out of 301 mid-stream urine samples, 99(33%) sample showed significant bacterial growth. Among them, 78(79%) were gram negative bacteria. Escherichia coli were the predominant organism. Multidrug resistant gram negative isolates were 65.4%. Among 78 Gram negative isolates, 31(39.7%) were extended spectrum β-lactamase producers. Among extended spectrum β-lactamase producers, 27(87.1%) were MDR. Highest frequency of extended spectrum β-lactamases production was seen in E. coli, 23(74.2%). Majority of gram negative bacteria showed susceptibility toward colistin and nitrofurantoin. Ampicillin was found to be highly resistant towards gram negative uropathogen.
Conclusions: This study found that higher proportion of multi-drug resistants were among gram negative isolates and further more among extended spectrum β-lactamase producing gram negative isolates. Thus, there is urgent need to address the issue of antimicrobial resistant and promote rational use of the antibiotics in our region.
Relevamiento florístico y análisis comparativo de comunidades arbóreas de Sierra de Ríos (Cerro Largo - Uruguay)
Authors: Grela I. , Brussa C.
Published: January 2023

Se realizó un relevamiento florístico en comunidades arbóreas nativas de la Sierra de Ríos (Cerro Largo) con el objetivo de aumentar el conocimiento de la flora del noreste del país y de comprobar si las diferencias fisonómicas entre las formaciones arbóreas están sustentadas mayoritariamente en diferencias de composición florística. Se relevaron 32 sitios que se clasificaron de acuerdo a su fisionomía en bosques ribereños, bosques de quebradas, bosques pantanosos (o capones) y bosque serrano. La composición florística se determinó en base a datos de presencia/ausencia de especies. Ochenta y ocho especies arbóreas pertenecientes a 34 familias fueron detectadas, algunas de ellas son especies muy raras en el país e incluso se detectó una especie no citada anteriormente para la flora del Uruguay. Se efectuaron análisis de correspondencias y de conglomerados para detectar patrones de distribución y agrupamientos de sitios y especies. Estos análisis demostraron que las diferencias fisonómicas no necesariamente están determinadas por diferencias claras en la composición florística. Se encontró una alta variabilidad en las frecuencias de aparición de las especies lo que dificultó la identificación de agrupamientos bien definidos. El análisis de conglomerados mostró que los índices de similitud (índice de similitud Czekanowski) son en general bajos lo que puede estar explicado por la presencia de una gran cantidad de especies con una muy baja frecuencia de aparición entre los sitios.
Cuantificación mediante lisímetros del lavado de bases en suelos, bajo dos regímenes hídricos
Authors: Casanova O. N. , Ferrando M. G.
Published: January 2023

Bajo el régimen de precipitaciones de Uruguay, el lavado o lixiviación de cationes con el agua de drenaje, resulta en una paulatina desaturación del suelo, especialmente en suelos de baja CIC. Finalmente, este proceso puede conducir a un enriquecimiento en cationes de las napas profundas, acidificación del suelo y una pérdida de la fertilidad natural. Cinco suelos agrícolas representativos del Uruguay, fueron evaluados durante tres años, mediante el uso de lisímetros. Los tratamientos fueron 1) testigo con lluvia natural, 2) aplicación adicional de 150 mm de riego luego de la siembra, con cuatro repeticiones. La rotación anual del uso del suelo, fue un cultivo de invierno (cebada) y barbecho en verano. Todos los lisímetros fueron fertilizados con 100kg ha-1 de N y de P, a la siembra del cultivo. Luego de cada evento de lluvia, se determinó el total de agua de drenaje y si material de origen y régimen hídrico. El total lixiviado en los tres años avaluados, varió entre 288 y 617kg ha-1 de bases. Calcio (55-351 ha-1) y sodio (11-314 ha-1), fueron los elementos más contrastantes, mostrando una estrecha relación con el tipo de suelo. Para el período estudiado, el lavado de bases no fue de tal magnitud, como para afectar significativamente las cantidades intercambiables en el suelo.
Pseudomonas viridiflava (burkholder) dowson: agente causal de manchas necróticas en hojas de cebolla y ajo (Allium spp.) en Uruguay
Authors: Pérez Faggiani E. , Silvera Pérez E. , Gepp Ward V.
Published: January 2023

Manchas y estrías amarillentas fueron observadas en hojas de cultivos de ajo y cebolla instalados en predios de la zona hortícola del sur de Uruguay. Se aislaron bacterias de las hojas afectadas de ambas especies, las que fueron identificadas como Pseudomonas viridiflava (Burkholder) Dowson mediante el uso de técnicas bioquímicas tradicionales. Ambos aislamientos se inocularon en plantas y bulbos de ajo y cebolla en condiciones controladas, produciendo síntomas similares en ambas especies. Este trabajo representa la primera comunicación científica referente a P. viridiflava como causante de enfermedad en ajo en condiciones de producción.
Algunas evidencias del desarrollo de vertisoles de Uruguay a partir de rocas cristalinas básicas
Authors: Bossi J. , Durán A. , Maldonado S.
Published: January 2023

Los Vertisoles son suelos de alta fertilidad natural y difícil manejo, extremadamente comunes en Uruguay no muy frecuentes a escala mundial. La naturaleza de su material parental ha interesado a la pedología desde hace varias décadas. Las descripciones de perfiles anexas a la Carta de suelos de Uruguay a escala 1/1.000.000 del año 1976 concluyen siempre que se desarrollan sobre limos cuaternarios o areniscas con abundantes esmecitas. Sin embargo, el análisis de la distribución regional de estos suelos permitió demostrar que los Vertisoles Háplicos se encuentran exclusivamente en áreas basálticas y que dos unidades de asociaciones con Vertisoles Rúpticos y Brunosoles Eutricos codominantes (Unidades La carolina e Isla Mala) coinciden con áreas de subsuelo cristalino en la que abundan rocas básicas (anfibolitas, gabros, prasinitas). En las tres zonas dominan los fenómenos de meteorización sobre la erosión porque pertenecen a bloques en hundimiento isostático. El estudio detallado de algunos perfiles también sugiere la proveniencia por meteorización en sitios de rocas cristalinas ya que contienen gravas a escasos centímetros de la superficie. Este ensayo es una primera contribución que sugiere la posibilidad de formación de Vertisoles en Uruguay por meteorización de tocas básicas y la necesidad de un estudio detallado porque su verificación textural, mineralógica y geoquímica permitirá reconocer y georeferenciar. Vertisoles de diferente composición y contribuir a establecer las condiciones óptimas de manejo.
La adopción de tecnología “Soft” en la lechería uruguaya para el manejo de la información: un estudio de caso en Florida, Uruguay, 2º parte
Authors: Álvarez J.
Published: January 2023

Con el objetivo de profundizar el conocimiento sobe los factores que promueven o desalientan el uso de software para el manejo de la información a nivel predial se realizó un estudio involucrando a 61 productores lecheros ubicados en Florida, Uruguay. Los resultados obtenidos muestran que la probabilidad de utilizar software responde a las mismas variables identificadas en estudios anteriores sobre la adopción de computadoras. Entre estos factores se destaca el tamaño económico de los predios y la educación formal del productor. Al mismo tiempo, este estudio también ha permitido identificar el efecto de otros factores (factores no previamente reportados por la literatura) incluyendo variables que intentan describir la personalidad del productor, sus estilos de aprendizaje, sus metas y sus objetivos. El análisis factorial mostró un complejo interrelacionamiento entre variables explicativas estudiadas. Este conocimiento puede ser útil a la hora de decidir el uso de este tipo de herramientas, tanto para el productor como para el técnico asesor, y consecuentemente redundara en un uso más provechoso de dicha tecnología.
Penerapan Metode Weighted Product Dalam Pengambilan Keputusan Guru Terbaik Pada PKBM Satria Purwokerto
Authors: Lutfi Dien Kartika , Hidayatulloh Syarif
Published: January 2023

Guru yang bertugas dalam kegiatan belajar mengajar pada pendidikan non-formal PKBM telah membimbing peserta didik dengan penuh kesabaran, ketekunan dan pegabdian untuk membantu mencerdaskan peserta didik dengan memberi ruang bagi warga masyarakat untuk mendapatkan pendidikan kesetaraan. Selama ini di PKBM Satria Purwokerto belum pernah dilakukan penentuan guru terbaik. Penilaian terhadap guru yang mengajar di PKBM Satria Purwokerto hanya dilakukan secara subjektif berdasarkan asumsi Kepala PKBM Satria Purwokerto tanpa mempertimbangkan apapun dalam melakukan penilaian. Untuk itu dengan menerapkan metode Weighted Product dalam proses penentuan guru terbaik pada PKBM Satria Purwokerto dapat dijadikan solusi untuk memecahkan permasalahan yang terjadi. Dalam menerapkan metode Weighted Product ini dilakukan ke dalam beberapa tahapan dimana diawali dengan menentukan kriteria apa saja yang akan digunakan, menentukan bobot untuk setiap kriterianya serta data dari alternatif yang akan digunakan. Setelah itu dilakukan normalisasi bobot kriteria, kemudian melakukan perhitungan nilai vector S dan yang terakhir adalah melakukan perhitungan vector V yang dimana nilai dari vector V adalah hasil penentuan guru terbaik PKBM Satria Purwokerto. Dengan menerapkannya metode Weighted Product diharapkan dapat menjadi solusi terbaik dalam melakukan penentuan guru terbaik pada PKBM Satria Purwokerto. Sehingga menghasilkan penilaian terhadap guru PKBM Satria Purwokerto yang objektif.
Klasifikasi Penerima Bantuan Sosial Menggunakan Algoritma C 4.5
Authors: Junaidi Agus , Yunita Yunita , Agustyani Sarifah , Agustyaningrum Cucu Ika , Arifin Yoseph Tajul
Published: January 2023

Saat pandemi Covid-19 mulai melanda di Indonesia, banyak pembatasan yang diterapkan oleh pemerintah untuk membatasi merebaknya virus tersebut. Masyarakat dan dunia usaha secara otomatis juga mengalami ketidakstabilan dalam perekonomian karena pembatasan tersebut. Oleh karena itu pemerintah juga mulai membuat kebijakan untuk melindungi perekonomian masyarakat dengan menyalurkan bantuan sosial kepada desa atau kelurahan diseluruh Indonesia. Penelitian ini bertujuan untuk memberikan kontribusi yang nyata tentang kelayakan penerima bantuan agar penyaluran bantuan benar-benar tepat sasaran sehingga bisa mengangkat perekonomian masyarakat yang turun drastis karena pandemi ini. Metode dalam penelitian ini menggunakan metode survey lapangan dengan memberikan batasan kriteria pada pendapatan bulanan, jumlah tanggungan, jenis tempat tinggal, dan kendaraan yang dilakukan pada salah satu kelurahan di wilayah Tangerang dengan metode klasifikasi C4.5. Hasil output dari penelitian ini adalah menentukan apakah penerima bantuan yang terdaftar tersebut layak atau tidak layak untuk menerima bantuan yang dapat dijadikan rekomendasi oleh pengambil keputusan, dalam hal ini pihak kelurahan untuk menyeleksi warganya.
Feasibility Analysis of Establishing a Folding Dacron Mattress Business at Home Industry Puhpelem Wonogiri
Authors: Darsini Darsini , Asrori Asrori , Marwahyudi Marwahyudi
Published: January 2023

The establishment of home industries needs to be assessed for initial efforts to see whether the enterprise is worthy to establish or not. The study aims to learn the worthiness of the dacron bed business Pure Plembang Puhpelem, Wonogiri from non-financial and financial analyzed by the Payback Period (PP), Net Present Value (NPV), Net Benefit-Cost Ratio (Net B/C), and the Internal Rate of Return (IRR). The study is qualitative-quantitative. The research subject is the home industrial bed Pure Plembang Puhpelem, Wonogiri with the dacron tree-worthy research object. Research indicates that (1) Due to market and marketing aspects, the dacron bed was more deserving because the monthly demand in each region had met its monthly target of production, (2) From the technical aspects of the dacron bed business, it was worth running, due to the location close to the existing labor and salary, (3) From the environmental aspect of the environment, the dacron is worth running because it can help the economy around the shop and is scant, and (4) From the financial aspect, with Capital Budgeting obtained PP over 5 Years 3 Months shorter than 10-year investment, NPV Rp 39,553,430 where NPV > 0, Net B/C is acquired 1.22 > 1, and IRR is 14% greater than the current interest rate (DF) at 9%. From these results, it is concluded that the financial aspect is worthy of execution.
Public Perceptions of The Government in Handling Covid-19 Pandemic with Covid-Score-10 Approach and Dematel Analytical Network Process (DANP)
Authors: Berlianty Intan , Soejanto Irwan
Published: January 2023

COVID-19 puts intense pressure on governments to take unprecedented and rapid action around the world in dealing with the COVID-19 pandemic. This research takes steps to determine the public's assessment of government programs to resolve the COVID-19 pandemic. The most likely solution is to use the combined method of the Covid Score and the Analytical Network Process (ANP) in determining how to increase public support for government programs to resolve this pandemic. The results of the data processing provide a significant picture of support for the government by 34% in handling the pandemic. To increase wider community support, it is proposed to apply more stringent rules as shown in the ANP value of 16.2. Research contribution to implementing COVID SCORE 10 with Analytical Network Process (ANP) review for implementation in Covid-19 cases in the sample area
Rancang Bangun Pengering Buah Pinang Otomatis Menggunakan Pendekatan Quality Function Deployment (QFD)
Authors: Wahyudi Tri , Rahmahwati Ratih , Uslianti Silvia
Published: January 2023

The processing of dried betel nut by the people of West Kalimantan consists of 2 stages, namely drying and stripping the betel nut. The drying process usually carried out by farmers is drying directly in the sun, and the smoking process uses fire to heat. The method of drying the areca nuts takes about 14-15 days. This study will examine the problems faced by farmers in the process of drying areca nuts. Based on the issue of drying areca nuts, it is necessary to have an alternative method of drying that is more efficient. Areca nut drying machine is an alternative to obtain dried betel nut relatively quickly with well-maintained fruit quality. The design of the areca nut drying machine is made based on the identification of farmers' needs. Identifying farmers' needs or desires will be an attribute of product development, and technical parameters are determined to meet these product attributes. The method that will be used is the Quality Function Deployment (QFD) method. The study results that priority attributes must be completed based on calculations in the planning matrix using QFD. The design of the areca nut has dimensions of 260 mm x 490 mm, with the specifications of the tool consisting of two main parts, namely an inner filter (a place for betel nuts) and a betel nut dryer.
Mental Workload Analysis of PMM Outbound Student Using Defence Research Agency Workload Scale (DRAWS) Method
Authors: Khoiri Halwa Annisa , Isnaini Wildanul , Cahyaningtyas Putri
Published: January 2023

Merdeka Belajar Kampus Merdeka (MBKM) program provides opportunities for students to develop their abilities. One of the MBKM program is Pertukaran Mahasiswa Merdeka (PMM). This program provides option for students to attend lectures at other universitie, so the student can get experience regarding new experience. However, in other hand this program causes mental burden for students who join it. This is because the credits become greater. This study evaluates how the mental workload felt by students using DRAWS method. The results of this study, the most dominant indicator in PMM at PTN is Central Demand and in PTS is Time Pressure. Students who fall into overload category are 60% for PMM in PTN and 59% in PTS. Based on the results, the recommendations that can be given are improving time management for students and review how the policies about PMM so the students are not burden of credits.
Quality Control Analysis Using Flowchart, Check Sheet, P-Chart, Pareto Diagram and Fishbone Diagram
Authors: Nadiyah Khairun , Dewi Grita Supriyanto
Published: January 2023

SP Aluminum is engaged in the manufacturing industry by producing cooking utensils. In its application, SP Aluminum has tried to produce quality products to satisfy consumers. However, there are still defects that appear in its products. Another problem is the product defects have not been handled seriously by the company. Based on these problems, this study utilizes 5 quality control methods from seven tools: flowchart, check sheets, p-chart, Pareto diagram, and fishbone diagrams. This research is a quantitative qualitative with direct data collection through observation and interviews. The data taken is the product defect in Super Wok Number 12. There are 49 defects data that have been processed. From the results of the check sheet analysis, it was found that the intensity category of the product defects occurrence was obtained. Furthermore, control chart analysis show that there are some data that are out of control. Then, Pareto diagram analysis show the most dominant types of defects are holes, dregs, and pores. Finally, the factors of the absence of written SOPs, less thorough and less competent employees, poor working environment, lack of machine maintenance, poor handling of raw materials and inappropriate material handling processes were common causes of product defects.
Statistical Process Control (SPC) and Fuzzy-Failure Mode and Effect Analysis (F-FMEA) Approaches to Reduce Reject Products in Wine Bottle Rack Production Process at PT Alis Jaya Ciptatama
Authors: Nurdaningsih Nikma Wahyu , Yunitasari Elly Wuryaningtyas , Ma'arif Syamsul
Published: January 2023

PT Alis Jaya Ciptatama (AJC) is a company engaged in the furniture industry, where the products are exported. One of the products from PT AJC is a wine bottle rack. In the production of wine bottle racks at PT AJC, many product defects were found. Therefore, it is necessary to conduct further research to determine the quality of the product, so that the correct product quality improvement is obtained. The purpose of this study was to determine the limits of statistical control and the factors causing defects in wine bottle racks so that the quality improvement provided was right on target. The methods used in this research are Statistical Process Control (SPC) and Fuzzy Failure Mode and Effect Analysis (F-FMEA). SPC method is used to determine statistical control limits and factors causing product defects. The F-FMEA method is used to determine the priority of improvement in improving the quality of wine bottle racks. The results of the research related to the statistical control limits of the SPC method were obtained that the defective data were outside the statistical control limits. While the results of research related to the causes of product failure using the SPC method are human, machine, material, environmental, method, and measurement factors. Factors causing product failure were analyzed using the F-FMEA method so that improvement priorities were obtained, namely the lack of experience of workers with an FRPN value of 269.33. Improvements that need to be made by PT AJC include providing training to mill 1 workers and splitting the logs.
Proposed Design of Assistant Tools to Reduce the Risk of Disorders (MSDS) Operator of Weaving Work Station CV XYZ
Authors: Pratama Panji Yudha , Azmi Nora , Sari Indah Permata
Published: January 2023

The weaving operator of CV XYZ has an unergonomic work posture with a bent back and unbalanced legs at work. This non-ergonomic condition was identified by using the Nordic Body Map questionnaire to find out complaints on 28 body parts of three operators. From the identification of weaving operators using a nordic body map, it is known that there are complaints on the back, waist, and hips of the body. Identification using the Rapid Entire Body Assessment method shows that the final result of the assessment is 11, which means that there is a need for improvement now on the operator's work posture. The results of the QEC method show an exposure score of 97.12% for operator 3 and the action that must be taken is research and changes now. To reduce the risk of high work posture, a proposal for improving the working posture of the weaving machine set up operator was formulated by designing a manual scissor lift tool. In the process of designing tools, Indonesian anthropometric data is needed. The stages of designing tools are identifying operator needs, conceptualizing tools using a need metric matrix, selecting tools concepts with combination tables and scoring concepts and describing the design of tools using AutoCAD and CATIA software. From the results of the selection of several alternative concepts, a tool in the form of a manual scissor lift was chosen which has a combination of elements, namely a square working platform design, using 2 hydraulics and raw materials made of steel. Meanwhile, the manual scissor lift specification has a maximum height of 85 cm, a footing length of 70 cm and a footing width of 46 cm. It is known that before the proposed improvement, the final result of the REBA score was 11 and after the improvement the final result of the REBA score was 4 which indicates that the operator's work posture has improved after using the assistive device, especially in the arms, legs and back of the operator
Layout Redesign to Eliminate Stagnation Using Blocplan to Increase Production Efficiency
Authors: Wicaksono Danny , Setiawan Indra , Hasan Fitriana Lestari
Published: January 2023

The rapid growth of the automotive industry was also followed by growth in subsidiary companies. One of the subsidiary companies is a company that produces auto parts such as wheels. Sales volume in 2021 increased to more than 2 million products while for 2022 to April it was more than 1 million products. High demand is not accommodated due to inadequate production capacity, one of which is the machining area. This study aims to increase efficiency by redesigning the layout of the factory which is considered to increase production results in the machining area. The method used in this research is Block Layout Overview with Computerized Planning using Logic and Algorithm (Blocplan). The results showed that the redesign of the machining area could reduce stagnation by adding 1 unit of multi drill machine. Relayout in the machining area can reduce 93” time stagnation for the K2SA rear ABS type which can produce 2 outputs at once. The delay in the machining area can be reduced from 4,863 seconds to 0 seconds.
Simulation Model of Production System Using Dynamic System Approach to Increase Production Capacity Tofu Factory
Authors: Talitha Tita , Berliyana Rexza
Published: January 2023

The speed in distributing the products of the industry is influenced by the speed of production produced by the industry itself. SMEs know that ECO is one of the manufacturing industries engaged in food manufacturing. there are obstacles (problems) that are experienced, namely the occurrence of inequality between the production capacity of tofu that can be produced and the demand for tofu that must be met. The purpose of this study is to increase the production capacity of Tofu Eco SMEs in terms of increasing working time. The method used in this research is the dynamic system method using the PLE vensim software. The results of the study show that based on the actual system conditions, it is known that there are 25 workers with 8 working hours per day, and an average production capacity of 957 barrels per month is obtained month with an average demand of 1005 barrels /month. The results of the alternative simulation I, have an average production capacity of 1,080 barrels/month. The results of the scenario II simulation show that the average production capacity is 1,230 barrels/month. From the simulation results of alternative scenarios, it can be seen that for production demand below 1,080 barrels/month, the alternative used is to add 1 hour (60 minutes) of overtime, while for requests above 1,079 barrels/month with a maximum production demand of 1,255 barrels/month, alternative scenarios can be used. II with the addition of 2 hours 30 minutes (150 minutes) of overtime.
Motivasi Pengguna dalam Menggunakan Media Sosial dan Keterlibatan dengan Iklan Media Sosial
Authors: Paramita Dhyana
Published: January 2023

In the marketing field, social media advertising has become powerful medium to market products and services. The purpose of this study is to analyze the connection that exists between user motivation and the engagement of social media advertisements. In addition to that, the purpose of this study is to determine which kinds of social media have the highest levels of user involvement. A cross-sectional design with a self-administered questionnaire is used for the research methodology. The Chi-square test developed by Pearson is used as the correlation test for the investigation. Non-random sampling is used for the selection of the population, with a minimum sample size of thirty master's students from Uppsala University serving as the selection criteria. According to the findings, there is no connection between user motivation with their engagement in the online advertising. In addition, when it comes to online advertising, Facebook and Instagram are the two platforms that have the highest level of user engagement. The findings also suggest that there is a significant positive relationship between the most used channels and user engagement to online advertising.
Perbaikan Rute Distribusi Bahan Baku untuk Minimasi Jarak Tempuh dan Beban Kerja pada UKM Kuliner Mie
Authors: Link Lisa Amanda , Puspitasari Fransiska Hernina , Dewa Parama Kartika
Published: January 2023

Delivery activities have a great role for a business actor. However, delivery issues are there all the time. This was experienced by a noodle culinary SME that experienced delays in the delivery of various noodle raw materials and noodle toppings which caused noodle sales activities to be disrupted. In addition, these raw materials have a lifespan (without preservatives) so they must be delivered according to a predetermined schedule and hours. This research will solve this problem by minimizing delays through finding the shortest mileage delivery route. Because each delivery location has its own schedule and time window, the Nearest Neighbor method by paying attention to the time window is used. Based on the calculation results, each distribution route with the shortest distance was obtained, as evidenced by a reduction in the middle route by 0.23 km and the northern route by 5.88 km. In addition, this proposed delivery route was able to save fuel consumption on the middle route by 3% and the northern route by 10%. In terms of the workload aspect, car fleet drivers were also reduced by 31% and motorbike fleet drivers by 47%.
Diversidade e patogenicidade de fungos endofíticos em cafeeiro, e sua interação com produtos fitossanitários, visando ao controle do bicho-mineiro, Leucoptera coffeella (Lepidoptera: Lyonetiidae) (Guérin-Méneville, 1842)
Authors:   , Nunes Carolina Benevides Stefanoviciaus
Published: January 2023

A cafeicultura tem grande importância no cenário econômico brasileiro, sendo o maior produtor e exportador mundial de café. Uma das principais pragas do cafeeiro, é o bicho-mineiro (Leucoptera coffeella), responsáveis por prejuízos de até 70% nas culturas. Contudo, sua principal forma de controle, ainda é o uso de agrotóxicos, que ocasionam resistência em pragas, eliminação de organismos benéficos a lavoura e ainda, contaminação do meio ambiente. Para contornar estes problemas, é necessário o aprofundamento de estudos sobre controle biológico de pragas. Os fungos entomopatogênicos, podem se expressar de forma endofítica nas plantas, sem causar qualquer dano ao seu desenvolvimento e ter a capacidade de reduzir a população de pragas abaixo do nível de dano. O objetivo deste trabalho foi avaliar a diversidade de ocorrência de fungos endofíticos isolados de folhas, caules e raízes de cafeeiros orgânicos da região mogiana e paulista e o seu potencial entomopatogênico sobre o bicho-mineiro. Para isso, foram coletadas amostras vegetais de 4 propriedades, divididas em 4 pontos cardeais da planta (norte, sul, leste e oeste). Estes, passaram por um screening em larvas de Galleria mellonella e de todas as 101 morfoespécies isoladas, 18 apresentaram capacidade entomopatogênica na concentração de 1,0 x108 conídios ml-1 . A região de Itapira demonstrou maior quantidade de isolados com capacidade patogênica e as amostras provenientes dos pontos cardeais norte e sul, e da região do caule também apresentaram variabilidade superior. Os fungos Beauveria bassiana, Cordyceps fumosorosea e Aspergillus clavatonanicus causaram mortalidade de 52,34% - 70,86 e respectivamente, em larvas de L. coffeella. Tais fungos também foram testados quanto a sua compatibilidade com produtos fitossanitários e capacidade de colonização dos tecidos foliares por meio de pulverização em mudas de café. Os fungos A. clavatonanicus e C. fumosorosea apresentaram grande capacidade de colonização de tecidos foliares por pulverização e os fungos B. bassiana e 13E apresentaram compatibilidade com a maioria dos inseticidas testados.
Favoured Isles: Selfishness and Sacrifice in the Capital of Capital
Authors: Zacek Natalie
Published: January 2023

An important aspect of The Woman of Colour (1808) is its treatment of the linked concepts of selfishness, self-interest, and sympathy. Although its author does not mention Adam Smith, his discussion of these ideas in Theory of Moral Sentiments offers insights into both the novel’s plot and characters and its engagement with the ideals and practices of commerce, empire, and slavery. The protagonist, Olivia Fairfield, experiences numerous disappointments and betrayals during her stay in England, yet when she is about to return to her Jamaican home, she describes England as a “favoured isle” because it has produced some ideal men. In order for England and Jamaica to become “favoured isles,” it is essential that white residents of both locales abjure the selfishness that pervades imperialist and capitalist accumulation and treat everyone, including enslaved people, with sympathy. Doing so allows the novel’s several heroes to see themselves and be seen by others as benevolent, yet allows them to continue to reap the benefits of empire.
“Mind Is Revealed in the Countenance”: Subversive Laughter and Caricature in The Woman of Colour
Authors: George Leigh-Michil
Published: January 2023

Throughout The Woman of Colour (1808), Olivia Fairfield, the Black mixed-race heroine, ridicules the “fair sex” bodies of white female characters who irrationally judge the heroine as inferior because of the colour of her skin. In this article, I extend Lyndon J. Dominique’s reading of Olivia’s subversive gaze and laughter found in Imoinda’s Shade (2012). In building on Dominique’s insights, I show how Olivia paradoxically uses caricatural tropes of fat versus thin and young versus old to envision caricature on her own terms: to challenge and resist anti-Black stereotypes. When the novel is examined within the context of contemporary visual caricatures that depict the Black female body as grotesque, one recognizes that Olivia’s defensive use of verbal caricature is a rhetorically strategic attempt to challenge England’s racial hierarchy, by reaffirming her own femininity and “fairness.”
Violencia contra la mujer en el entorno de la atención obstétrica
Authors: Távara Orozco Luis
Published: January 2023

La violencia contra la mujer históricamente ha ocurrido en todos los tiempos y en todas las sociedades y ha sido el resultado del desbalance de poder existente entre hombres y mujeres en desmedro de estas últimas.