bluuebunny/crossref_metadata_2025 huggingface dataset:
Conception of Professionalism and Horizons in Acupuncture Sciences in Students of the Degree in Human Rehabilitation Acupuncture
Authors: Nava Miguel Alberto Gutiérrez , Castillo Saharaim Joseline Montiel , Vargas Nubia Denisse Nieto , Patiño Isaac Casas
Published: May 2023

The curricularization of the extension in the Rehabilitation Human Acupuncture axis is of great importance due to the health need that exists in the State of Mexico. The objective of this work was to evaluate the conception of professionalism and horizons in Acupuncture Sciences that the students of the Bachelor of Rehabilitation Human Acupuncture have in the fourth, fifth, sixth and seventh semesters of the State University of Valle de Ecatepec. Material and methods: An exploratory analysis was carried out in which a questionnaire of 10 open questions focused on the conception of professionalism was used for all students from the fourth to the seventh semester, later an analysis of the keywords of each question was made. to determine the words that had the highest degree of coincidence. The results: (P1) professionalism is related to having the necessary knowledge and correctly practicing acupuncture and rehabilitation; (P2) Knowledge and correct practice of the profession are characteristics of a good professional in Acupuncture; (P3) Knowledge, empathy and a good diagnosis are important skills that a graduate in Rehabilitation Human Acupuncture must have; (P4) Acupuncture as a degree is perceived as interesting, preventive and an excellent career; (P5) For the students, being licensed in Rehabilitation Human Acupuncture means helping; (P6) The skills that the students have developed during their training as graduates in human acupuncture and rehabilitation are observation, the ability to help, acupuncture support techniques, analysis, correct diagnosis and development of critical thinking; (P7) Acupuncture is viewed in 20 years as complementary and nationally and internationally recognized; (P8) The biosciences have an impact on the training as a graduate in rehabilitative human acupuncture so that they can integrate the knowledge acquired, understand the human body and give scientific support to acupuncture; (P9) The field of work in which the students are visualized is in an independent office; (P10) The area in which the students surveyed would like to specialize is rehabilitation and do a master's degree to broaden their knowledge.
Coronavirus (CoV) proteins in GtoPdb v.2023.1
Authors: Alexander Stephen P.H. , Ball Jonathan K. , Tsoleridis Theocharis
Published: May 2023

Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 years as serious human pathogens: SARS-CoV was identified as the causative agent in an outbreak in 2002-2003, Middle East respiratory syndrome (MERS) CoV emerged in 2012 and the novel coronavirus SARS-CoV-2 emerged in 2019-2020. SARS-CoV-2 is the virus responsible for the infectious disease termed COVID-19 (WHO Technical Guidance 2020).
Other 7TM proteins in GtoPdb v.2023.1
Authors: Bonner Tom I.
Published: May 2023

These proteins are predicted to have 7TM domains, but functional studies have yet to confirm them as G protein-coupled receptors.
SLC25 family of mitochondrial transporters in GtoPdb v.2023.1
Authors: Kunji Edmund R.S.
Published: May 2023

Mitochondrial carriers are nuclear-encoded proteins, which translocate solutes across the inner mitochondrial membrane. Mitochondrial carriers are functional as monomers and have six TM alpha-helices and the termini in the mitochondrial intermembrane space.
ABCB subfamily in GtoPdb v.2023.1
Authors: Vore Mary
Published: May 2023

The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [8, 1].
Cytochrome P450 in GtoPdb v.2023.1
Authors: Burns Kathryn , Helsby Nuala Ann
Published: May 2023

The cytochrome P450 enzyme superfamily (CYP), E.C. 1.14.-.-, are haem-containing monooxygenases with a vast range of both endogenous and exogenous substrates. These include sterols, fatty acids, eicosanoids, fat-soluble vitamins, hormones, pesticides and carcinogens as well as drugs. Listed below are the human enzymes, their relationship with rodent CYP enzyme activities is obscure in that the species orthologue may not metabolise the same substrates. Some of the CYP enzymes located in the liver are particularly important for drug metabolism, both hepatic and extrahepatic CYP enzymes also contribute to patho/physiological processes. Genetic variation of CYP isoforms is widespread and likely underlies a proportion of individual variation in drug disposition. The superfamily has the root symbol CYP, followed by a number to indicate the family, a capital letter for the subfamily with a numeral for the individual enzyme. Some CYP are able to metabolise multiple substrates, others are oligo- or mono- specific. CYP also catalyse diverse oxidation and reduction reactions. These include ring hydroxylation, N-oxidation, sulfoxidation, epoxidation, the dealkylation of N-, S- and O- moieties, desulfation, deamination, as well as reduction of azo, nitro and N-oxide groups.
Neuropeptide Y receptors in GtoPdb v.2023.1
Authors: Beck-Sickinger Annette G. , Colmers William F. , Cox Helen M. , Doods Henri N. , Herzog Herbert , Larhammar Dan , Michel Martin C. , Quirion Remi , Schwartz Thue , Westfall Thomas
Published: May 2023

Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Neuropeptide Y Receptors [158]) are activated by the endogenous peptides neuropeptide Y, neuropeptide Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP). The receptor originally identified as the Y3 receptor has been identified as the CXCR4 chemokine recepter (originally named LESTR, [139]). The y6 receptor is a functional gene product in mouse, absent in rat, but contains a frame-shift mutation in primates producing a truncated non-functional gene [84]. Three-dimensional structures have been determined for subtype active receptors Y1, Y2 and Y4 [211, 114] and inactive antagonist bound Y1 and Y2 receptors [240, 210]. Many of the agonists exhibit differing degrees of selectivity dependent on the species examined. For example, the potency of PP is greater at the rat Y4 receptor than at the human receptor [62]. In addition, many agonists lack selectivity for individual subtypes, but can exhibit comparable potency against pairs of NPY receptor subtypes, or have not been examined for activity at all subtypes. [125I]-PYY or [125I]-NPY can be used to label Y1, Y2, Y5 and y6 subtypes non-selectively, while [125I][cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP may be used to label Y5 receptors preferentially (note that cPP denotes chicken peptide sequence and hPP is the human sequence).
Somatostatin receptors in GtoPdb v.2023.1
Authors: Bosquet Corinne , Castaño Justo P. , Csaba Zsolt , Culler Micheal , Dournaud Pascal , Epelbaum Jacques , Feniuk Wasyl , Harmar Anthony , Hills Rebecca , Hofland Leo , Hoyer Daniel , Humphrey Patrick P. A. , Kreienkamp Hans-Jürgen , Lupp Amelie , Melmed Shlomo , Meyerhof Wolfgang , O'Carroll Anne-Marie , Patel Yogesh C. , Reisine Terry , Reubi Jean-Claude , Schindler Marcus , Schmid Herbert , Schonbrunn Agnes , Schulz Stefan , Taylor John E. , Tulipano Giovanni , Vezzani Annamaria , Wester Hans-Jürgen
Published: May 2023

Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST1-SST5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [98]). Activation of these receptors produces a wide range of physiological effects throughout the body including the inhibition of secretion of many hormones. Endogenous ligands for these receptors are somatostatin-14 (SRIF-14) and somatostatin-28 (SRIF-28). cortistatin-14 has also been suggested to be an endogenous ligand for somatostatin receptors [61].
Trace amine receptor in GtoPdb v.2023.1
Authors: Bonner Tom I. , Davenport Anthony P. , Foord Stephen M. , Maguire Janet J. , Parker William A.E.
Published: May 2023

Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families. The TA1 receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee for the Trace amine receptor [58]) has affinity for the endogenous trace amines tyramine, β-phenylethylamine and octopamine in addition to the classical amine dopamine [9]. Emerging evidence suggests that TA1 is a modulator of monoaminergic activity in the brain [94] with TA1 and dopamine D2 receptors shown to form constitutive heterodimers when co-expressed [30]. In addition to trace amines, receptors can be activated by amphetamine-like psychostimulants, and endogenous thyronamines.
Voltage-gated calcium channels (CaV) in GtoPdb v.2023.1
Authors: Catterall William A. , Perez-Reyes Edward , Snutch Terrance P. , Striessnig Jörg
Published: May 2023

Ca2+ channels are voltage-gated ion channels present in the membrane of most excitable cells. The nomenclature for Ca2+channels was proposed by [131] and approved by the NC-IUPHAR Subcommittee on Ca2+ channels [72]. Most Ca2+ channels form hetero-oligomeric complexes. The α1 subunit is pore-forming and provides the binding site(s) for practically all agonists and antagonists. The 10 cloned α1-subunits can be grouped into three families: (1) the high-voltage activated dihydropyridine-sensitive (L-type, CaV1.x) channels; (2) the high- to moderate-voltage activated dihydropyridine-insensitive (CaV2.x) channels and (3) the low-voltage-activated (T-type, CaV3.x) channels. Each α1 subunit has four homologous repeats (I-IV), each repeat having six transmembrane domains (S1-S6) and a pore-forming region between S5 and S6. Voltage-dependent gating is driven by the membrane spanning S4 segment, which contains highly conserved positive charges that respond to changes in membrane potential. All of the α1-subunit genes give rise to alternatively spliced products. At least for high-voltage activated channels, it is likely that native channels comprise co-assemblies of α1, β and α2-δ subunits. The γ subunits have not been proven to associate with channels other than the α1s skeletal muscle Cav1.1 channel. The α2-δ1 and α2-δ2 subunits bind gabapentin and pregabalin.
Blood coagulation components in GtoPdb v.2023.1
Authors: Wong Szu S.
Published: May 2023

Coagulation as a process is interpreted as a mechanism for reducing excessive blood loss through the generation of a gel-like clot local to the site of injury. The process involves the activation, adhesion (see Integrins), degranulation and aggregation of platelets, as well as proteins circulating in the plasma. The coagulation cascade involves multiple proteins being converted to more active forms from less active precursors (for example, prothrombin [Factor II] is converted to thrombin [Factor IIa]), typically through proteolysis (see Proteases). Listed here are the components of the coagulation cascade targeted by agents in current clinical usage or at an advanced level of development.
1H. Liver X receptor-like receptors in GtoPdb v.2023.1
Authors: McDonnell Donald P. , Safi Rachid
Published: May 2023

Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [76, 3]) are members of a steroid analogue-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids. In humans and primates, NR1H5P is a pseudogene. However, in other mammals, it encodes a functional nuclear hormone receptor that appears to be involved in cholesterol biosynthesis [80].
Isolation of Bacterial Pathogens Associated with Commercially Available Spices in Mangaluru City, India
Authors: Hebbar Chaithra S. , Kenjar Apoorva R. , Raj Juliet Roshini Mohan , Karunasagar Iddya , Vittal Rajeshwari
Published: May 2023

Spices are important sources of natural flavouring, colouring and antimicrobial agents in food and medicine. In India, spices are widely produced, consumed and exported across the world. Like many other agricultural commodities, spices are exposed to a wide range of bacterial contamination during their harvesting, processing and transportation causing foodborne illnesses. Spices in their desiccated form offer an environment conducive to the survival of many pathogenic bacteria which becomes challenging for spice manufacturers to control or mitigate any bacterial contamination. The present study aimed at the isolation, phenotypic and genotypic identification of bacterial pathogens namely Salmonella spp., Bacillus cereus, Staphylococcus aureus and Escherichia coli associated with spices collected in and around Mangaluru, Karnataka. Isolation of bacterial pathogens was performed using a modified standard FDA BAM methodology. A total of 140 spice samples inclusive of pepper, clove, cumin, red chillies, turmeric, coriander, clove and fennel in whole and powdered form were screened for pathogens. No targeted bacterial pathogens were present in the samples collected. It can be inferred that good agricultural, manufacturing and hygienic practices were maintained in the commercial supply of spices. The absence of bacteria could also be attributed to the inherent antimicrobial properties of spices.
Strengthening of Concrete by Partial Replacement of Fine Aggregate with Stone Dust
Authors: Soni Nesh , Yadav Gaurav , Parakh Ashish , Nazim Md Ayaan , Deshmukh Devendra Kumar , Dewangan Purab
Published: May 2023

Abstract: In refurbishment projects a great deal of the water from existing structure is generated at the demolition stage. The study applies the waste concrete from construction and demolition waste in concrete and provide a case example for the construction industry to implement the recycle, reuse, and reduce principal to aher the management policy of waste concrete. Experimental investigation was carried out of to study various engineering properties such as workability, compressive strength, qualitative and quantitative study. It high lights various combinations of recycled aggregate to match with normal grade concrete. Research project investigation the influence of different percentage of recycled coarse aggregate obtained from demolished building 30 years old on the properties of construction and demolished waste concrete. Experimental result are holds good and shows better strength as compared to normal concrete cured 28 days. This study conducts the performance analysis and optimize the overall calculation for mix design. The result indicated that larger fractal dimension of aggregate would lead to the worse appeal performance of concrete.
Remote Monitoring and Safety System for Women
Authors: Peddada Sri Naimisha , Pranav Pendyala Sai Venkata , Vamshi Sankuri
Published: May 2023

Abstract: The escalating risks in contemporary society have made ensuring the protection of women a primary concern. This idea aims to create a real-time safety system with dual functionality by integrating different components to safeguard women. The operating principle entails the interaction of two devices to establish an effective surveillance and tracking system with a suitable alternative. A safety device that fits into a person's baggage is developed for the purpose. The system delivers several notifications to warn individuals with a single trigger of a switch or a vibration sensor, eliminating the need for many other sensors. To begin, the system uses Global Positioning System (GPS) to track the geographical location and delivers SMS/call notifications through Global System for Mobile Communication (GSM) to register contact numbers or a police station in proximity. Secondly, a buzzer alert will notify residents in the neighbourhood. A red led is a second attempt to awaken the surroundings and highlight the urgency of the issue. Through the live recording, a camera captures the attacker as well as a glimpse of the location, which can be viewed online. Finally, a temporary defense might be implemented by creating a shock wave that causes a jolt to an opponent, this time can be used by the person to escape from the area. The second component of the system encompasses the construction of a patrolling robot that moves in the direction of the sound received from the safety device and then continues live monitoring with a camera mounted on top of it that can be viewed by another segment of responsible people currently employed for the purpose.
Decentralized Asset Marketplace
Authors: Naik Shruti , Bhujbal Rucha , Chavan Tejas , Nishad Shubham , Mishra Aayush
Published: May 2023

Abstract: The decentralized asset marketplace is a cutting-edge platform that simplifies the buying and selling of non-fungible tokens (NFTs) by providing a secure and transparent peer-to-peer trading platform. The marketplace is built on the Ethereum blockchain, ensuring that transactions are immutable, secure, and transparent. It allows users to buy, sell and trade NFTs using cryptocurrencies such as Ethereum and Bitcoin. The smart contract that powers the platform defines a MarketItem struct that represents an NFT on sale and has several functions to support trading. The platform is designed to provide a seamless user experience with fast and efficient transactions, and performance enhancements such as using IPFS to store NFT metadata. The platform's benefits include increased security, transparency, and cost-effectiveness, making it a significant breakthrough in the world of NFT trading. Overall, the decentralized asset marketplace provides a safe, secure, and efficient way for users to trade NFTs without intermediaries or complex transaction processes.
Cyberbullying Detection using Machine Learning Algorithms
Authors: Kadam Bhagyashree
Published: May 2023

Abstract: In today's digital age, the internet has become an integral part of our lives, resulting in an exponential increase in the volume of data generated. However, this surge in online activity has also led to the emergence of cyberbullying as a major concern in web 4.0. Cyberbullying refers to the use of technology to intimidate, harass or threaten an individual, and is considered a form of cybercrime. Given the lack of available datasets, anonymous identities of perpetrators and the privacy of victims, previous research in cyberbullying detection has been limited. To address this issue, a new approach based on text mining and machine learning algorithms is proposed to proactively detect bullying text. Unlike previous research, which only considered textual features, the current study extracts three types of features: textual, behavioural and demographic features. Textual features include specific words commonly used in cyberbullying, which may indicate the presence of bullying behaviour. Behavioural features are based on personality traits and are extracted to determine the likelihood of a user engaging in bullying behaviour in the future. Demographic features, such as age, gender and location, are also extracted from the dataset. Overall, this text mining approach using machine learning algorithms can effectively detect cyberbullying, providing a valuable tool to combat this growing concern in the cyber world.
Driver Drowsiness Monitoring System using Machine Learning
Authors: Srivastava Sanjeevani
Published: May 2023

Abstract: In today's world, sleepiness is one of the main causes of road accidents, many of which have tragic outcomes. Statistics show that the majority of traffic collisions, which frequently result in fatalities and serious injuries, are caused by sleepy driving. As a result, various studies have been done to develop software that can recognize driver tiredness and alert them before making a major error. Using methods from the automobile industry, several of the more popular ways to design their own systems. However, other factors, such as vehicle type, road design, and the capacity to operate the driver's wheel, significantly impacted these traditional criteria. In order to monitor a driver's drowsiness, certain techniques use psychological methods, which frequently produce the most accurate and dependable results. These methods are expensive, though, because electrodes must be applied to the head and torso. This paper describes a machine learning approach to sleepiness detection. The areas of the driver's eyes are located using face detection, and these regions serve as templates for eye tracking in subsequent frames. Finally, drowsiness detection is performed on the tracked eye images to produce alarm warnings. The three steps of this method are Face detection, Eye detection, and Drowsiness detection. Image processing is used to identify the driver's face, and after that, the image of the driver's eyes is extracted to look for indicators of sleepiness. The HAAR face detection algorithm uses image frames that have been captured as input before producing the detected face. To generate results, the model is provided with a sizable database of closed and open eyes. Every time the driver is observed to be sleepy, Buzz alerts the driver. The suggested method for real-time driver drowsiness detection is a practical and affordable approach.
Mathematical Anxiety among Secondary School Students CBSE of Hyderabad with Respect to Gender
Authors: Baba Mohammad Azgar Ali
Published: May 2023

Abstract: The present study is an attempt to examine “Mathematical Anxiety Among Secondary School Students CBSE of Hyderabad with respect to Gender”. For this purpose, sample of 100 students (50 boys and 50 girls) of class 9th of secondary schools (CBSE) in Hyderabad are approached. The data is collected by administering the Mathematical Anxiety Rating ScaleRevised prepared by Barbara S. Plake and Clair S. Parker (1982) and is further analyzes with the help of SPSS software ver.23. For data analysis, the significance of the test is calculated using t-test of correlation for the level of significance at 0.005. The finding of the study reveals there is no significant difference among boys and girls of CBSE at secondary school level. Role of gender is found on the variables examined. Applying the findings, the educational implications are further discussed by the researcher
Green Synthesis of Ag-Ni Bimetallic Nanoparticle-Incorporated PVA/AA Hydrogel with Antimicrobial Properties
Authors: Ruparel Yuvraj M.
Published: May 2023

Abstract: In the treatment of burns, inert hydrogels are an essential component of first aid. If there is no access to clean water or if the burns are severe, hydrogel dressings may be used to cool burn wounds instead of running water. Hydrogels that have a high percentage of water content may help to disperse the heat that accumulates on the skin because of their properties. This will not only alleviate the pain, but it will also keep the region clean and guard it from any further damage. The primary objective of current research work is to provide a method for producing bimetallic Ag-Ni nanoparticles using a plant extract as the starting material. After that, these nanoparticles are mixed into a PVA/AA hydrogel that has a property that makes it appropriate for use in medical applications. Because of the antibacterial properties possessed by the nanoparticles found in hydrogel, the two substances working together may be used to hasten the healing process. The PVA/AA medical-grade polymer that was utilised in the creation of the hydrogels does not cause skin irritation and does not cause damage to the natural environment. We used environmentally friendly, one-pot green synthesis approach to synthesise Ag-Ni nanoparticles in a PVA/AA matrix. They function as antibacterial agents that are particularly efficient owing to the size of the particles, which is 12 nm, and their goal is to help in the quick healing of burn wounds and provide protection against E. coli.
Development of SnO2: Ag Nanoparticle as an Affordable Catalyst for the Degradation of Gentian Violet Dye
Authors: Mubeenabanu A.
Published: May 2023

Abstract: An effective visible catalyst (SnO2:Ag) was successfully synthesized using co-precipitation method for the decomposition of the dye Gentian Violet (GV). In addition to XRD, SEM and UV – Visible analysis, a variety of other physicochemical measurements were used to validate the as-prepared SnO2:Ag nanoparticles. The phase identification of prepared sample is characterized by X – ray powder diffraction (XRD), which confirms the tetragonal rutile structure. The surface morphology is examined using a scanning electron microscope (SEM) and the optical absorption and the band gap value are calculated using the UV-visible spectrum. These results confirm the synthesis of nanoparticles by successive steps. A nanoparticles was demonstrated to be a superior catalyst for the degradation of GV dye when exposed to UV light. The photocatalytic activity studies are discussed using SnO2:Ag nanoparticles. The degradation efficiency of the nanoparticle is 96 % towards the degradation of the GV dye
Social Entrepreneurship on Gen Z Students
Authors: Khwarazmita Tsabita
Published: May 2023

This study aims to reveal the dimensions that can influence social entrepreneurial intentions in Generation Z students. This study re-examines the usefulness of social entrepreneurship dimensions by earlier studies, such as innovation, proactiveness, and risk-taking with diverse objects. Using a population of 1500 from 2018-2020 private students who are contained in generation Z. The sampling technique utilized is convenience sampling with a sample of 98 people. Processing of data using SmartPLS 4.0. The results of data processing indicate that in this subject innovation and risk-taking have a significant effect on the social entrepreneurial intention of generation Z. Meanwhile, there is no proactive effect on the social entrepreneurial intention of generation Z.
Isolation, identification and comparative analysis of 16S rRNA of Multidrug-resistant Bacteria Clinically isolated from Al Qassim Region Hospitals in Saudi Arabia
Authors: Alkhowaiter H.S. , Alyahyawy Othman Yahya , Aljeddawi Abdullah Abdulhafeez , Abo-Aba Salah El-Deen Mohamed
Published: May 2023

Objective:   This study concluded that the antibiotic resistance and gene transfer across bacterial strains in the hospital setting are two possible explanations for the observed sequence changes in the target microorganisms.

Methods:   The 16S rDNA genes of all isolates were effectively amplified using PCR, and detailed identification results were derived from GenBank databases. The BLAST search resulted in the classification of 28 isolates into five strains. The GC content of bacterial sequences varies greatly between single species.

Results:  16S rDNA was utilized to identify bacterial species from isolates strains results demonstrated that identification of bacterial strains. Sequences varied between and within strains, also, variation are noticed in genomic nucleotide content of isolated and identified strains. Results of the present study demonstrated that the observed heterogeneity in the sequences of our target bacterial strains may be linked to antibiotic resistance and gene transfer between bacteria that evolved as a result of the hospital environment.

Conclusion:  This study concluded that antibiotic-resistant bacteria are capable of transferring copies of their DNA encoding a resistance mechanism to other bacteria, even those that are distantly related to them. the observed heterogeneity in the sequences of our target bacterial strains may be linked to antibiotic resistance and gene transfer between bacteria that evolved as a result of the hospital environment.
Educación financiera en el personal uniformado de la Policía Nacional
Authors:   Policía Nacional de Colombia, Gutiérrez Otálvaro Fernando Albeiro , Cipagauta Diaz Miguel Antonio ,   Policía Nacional de Colombia, Cañas Cañas Carmen Sofía ,   Policía Nacional de Colombia
Published: May 2023

El presente libro, es el resultado de la investigación del proyecto institucional ESVEL 2020, dirigido al análisis de los conocimientos y competencias en el campo de las finanzas personales, que investigan las prácticas financieras, el endeudamiento y el ahorro en el personal de la policía de la Región Nro. 5. La investigación contó con dos fases; en la primera se llevó a cabo un estudio descriptivo con 1233 policiales de la Región de Policía Nro. 5 en donde se aplicó una encuesta acerca de los patrones de manejo financiero, con énfasis en el sobreendeudamiento. En la segunda fase, se investigó la efectividad de un curso en educación financiera; esta fase presentó un pretest y un postest que evaluó conocimientos financieros de los participantes y los cambios obtenidos a partir de la intervención. En los resultados se evidencia la necesidad de una estrategia educativa que aborde la educación económica y financiera de la Institución , para mejorar la calidad de vida de las personas y prevenir problemas de sobreendeudamiento que pudieran obrar como factores de riesgo para la corrupción.
Temas Atuais de Direitos Humanos: Efetividade da justiça e direitos humanos processuais - volume 4
Authors: Bruna de Oliveira Simões Bárbara , Bitencourt Daniella , Costanza Graziele , Eduardo Aidikaitis Previdelli José , Paulo Kulczynski Forster João
Published: May 2023

No quarto volume desta coletânea "Temas Atuais de Direitos Humanos", seguindo tendência inaugurada por seu antecessor, apresenta temática específica: a efetividade da justiça e os direitos humanos processuais. A escolha desta temática está direcionada ao reforço da prática dos processuais sob a perspectiva dos direi- tos humanos, assim como a efetividade da justiça, conectando estudos que - para fins acadêmicos se distanciam do direito material para apresentar analiticamente outros mecanismos que integral o rol de direitos humanos. Os autores e as autoras trazem em suas pesquisas científicas que apresentam como lastro o resultado de atuações acadêmicas e profissionais em diversas áreas do direito, todas com o mesmo ponto em comum: o processo permeado pelos direitos humanos. O resultado que se apresenta é uma obra plural, abrangendo diversos ramos e áreas de atuação, na expectativa de contribuir para o debate das questões trazidas.
Very Small Embryonic-Like Stem Cells
Authors: Sanna Pierdanilo , Abdel Hadi Loubna , Rivero-Jimenez Rene Antonio , Bencomo-Hernandez Antonio Alfonso , Maher Ahmed Yasmine , Torres-Zambrano Gina Marcela , Ventura-Carmenate Yendry
Published: May 2023

Continuous and growing research studies regarding the clinical applications of the pluripotent or multipo-tent stem cells with their potential to differentiate into three germ layers are very well conducted in regenerative medicine (RM). In this review, we report the recent clinical applications and potential use of very small embryonic-like stem cells (VSELs) in orthopedics. VSELs are nonhematopoietic (CD45 - / Lin -), rare, and very small cells; they were reported as “dormant” cells in the bone marrow (BM), but are also found in cord blood, peripheral blood (PB), and in adult organs. Based on their capability to express markers of pluripotency (such as Oct-4 +/Nanog +/SSEA-1/4+/CXCR4+), it has been hypothesized that these cells could be early deposited during the embryonic development as descendants of epiblast-derived stem cells and perhaps from some primordial germ cells. VSELs can be released or mobilized from the BM to the PB during tissue injury and stress, facilitating the regeneration of damaged tissues. As well as mesenchymal stem cells, nowadays VSELs can be expanded ex vivo. Their pluripotency could be suitable for applications in RM, solving several problems regarding the use of both controversial embryonic stem cells and induced pluripotent stem cells. VSELs studies will hopefully open new frontiers to better understand their potential that would be relevant for future applications in RM and translational research.
Chemical Synthesis, Characterization and DNA Binding Studies of 2, 4- Dihydroxy Acetophenone Pramipexole Schiff Base Metal Complexes
Authors: Begum T.Noorjahan , Aruna K. , Jayaraju A.
Published: May 2023

Schiff and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities, including antifungal, antibacterial, anti-malarial, ant proliferative, anti-inflammatory, antiviral, and antipyretic properties. Many Schiff base complexes show excellent activity in various reactions in the presence of moisture. Over the past few years, many reports have been on their applications in homogeneous and heterogeneous catalysis. The influence of certain metals on the biological activity of these compounds and their intrinsic chemical interest as multidentate ligands has prompted a considerable increase in the study of their coordination behavior. The development of new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. The present paper deals with synthesizing and characterizing metal complexes of new Schiff bases derived from Pramipexole (4, 5, 6, 7-Tetrahydro-N6-propyl-2, 6-benzothiazole diamine) and 2,4- dihydroxy acetophenone (2,4 DHAP) by using modified Sand Mayer's method. Synthesized complexes were characterized by several techniques using IR, 1HNMR, UV-visible spectrometry, TG-DTA, and Conduct Metric Titrations. Infrared spectral data indicate the coordination between ligand and central metal ion through deprotonated phenolic oxygen and azomethine nitrogen. In addition, the authors have screened the compounds for DNA binding studies. It was found that these complexes bind DNA with high affinities.
Persepsi Masyarakat Terhadap Keberadaan Rumah Pemotongan Ayam (RPA) Toriniku di Kelurahan Birobuli Utara Kecamatan Palu Selatan Kota Palu
Authors: Rahayu Ritha , Maksum Haerani , Syukur Suharno H. , Irfan Moh. , Afandi Afandi , Riandhana Taufiq Eka
Published: May 2023

Rumah Pemotongan Ayam (RPA) merupakan salah satu usaha yang dikelola oleh sebagian penduduk di Indonesia. Hal ini dikarenakan dapat memberikan keuntungan yang besar jika dikelola dengan baik termasuk pengelolaan limbahnya yang dapat meningkatkan ekonomi. Penelitian ini bertujuan untuk mengetahui Persepsi Masyarakat terhadap Keberadaan Rumah Pemotongan Ayam (RPA) Toriniku di Kelurahan Birobuli Utara Kecamatan Palu Selatan. Penelitian ini bertempat di Kelurahan Birobuli Kecamatan Palu Selatan di RPA Rumah Pemotongan Hewan, telah dilaksanakan pada tanggal 26 Juli sampai dengan 5 September 2020. Jenis penelitian yang digunakan adalah deskriptif kualitatif. Metode yang digunakan yaitu metode survey (observasi dan wawancara). Populasi dalam penelitian ini adalah seluruh masyarakat yang berada disekitar Rumah Pemotongan Ayam (RPA) Toriniku Kecamatan Palu Selatan Kelurahan Birobuli Utara yang berjumlah 128 orang. Penentuan jumlah sampel dengan menggunakan statistik deskriptif berdasarkan rumus Slovin sebanyak 15 orang dan metode pengambilan responden dengan menggunakan purposive sampling. Analisis data yang digunakan pada penelitian ini yaitu Statistik Deskriptif dengan menggunakan skala Likert. Hasil penilaian responden terhadap persepsi secara keseluruhan adalah cukup terganggu dengan total bobot 1034. Penilaian tersebut meliputi bau dengan indikator aroma, sangat menyengat dan tidak mudah hilang dengan bobot 254, suara dengan indikator suara ngorok, suara terus menerus dan suara keras dengan bobot 229, pengolahan limbah dengan indikator ditumpuk dikolam pembuangan dan kebersihan kurang dengan bobot 162 dan sosial budaya dengan indikator persetujuan masyarakat dan adaptasi bau dan suara dengan bobot 389.
TNP o TPAN
Authors: Lahoz Casas Daniel
Published: May 2023

Many international efforts have been made for the purposes of controlling, reducing, and prohibiting nuclear weapons. While the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) is the centerpiece of the current nuclear order, those most skeptical of the sustainability of nuclear deterrence advocate the establishment of a disarmament regime based on the Treaty on the Prohibition of Nuclear Weapons (TPNW). Within the European Union, we can notice a disparity of positions on this issue, both among organs and member states, which hinders the adoption of a coherent strategy. Addressing the impact of relevant issues such as the war in Ukraine and nuclear-sharing, the article outlines the challenging situation in which the EU finds herself. The article reviews the evolution of the EU’s role as an emerging actor in the European theater, describes the main possible models of nuclear order, and analyzes the most relevant challenges that the EU currently faces; challenges both endogenous (the divergence between bodies and member states) and exogenous (the risks arising from the war in Ukraine and the Iranian nuclear program). The article argues that, both for the sake of maintaining the current non-proliferation regime and of facilitating universal denuclearization, the EU needs to urgently address these challenges and help strengthen the NPT.
Contextualizando el debate sobre la ley de aguas y el derecho al agua en Guatemala
Authors: Padilla Vassaux Diego Antonio
Published: May 2023

In 2016, there was a renewal on the public debates surrounding the absent water law in Guatemala. The Guatemalan Congress received many law proposals amidst a public opinion outcry because of the socioenvironmental crisis that affects water sources in the country. The fact that the Government hasn´t approved a water law in thirty years, even though the 1985 Constitution demands one, is a flagrant water management issue. It is also an issue of power. This enquiry was based on a need to understand how the human rights to water debate was inserted in this context, the reasons and motives the parties that took part had to affirm the need to regulate on the matter, or, on the contrary, to omit it from the discussions. In this sense, the institutionalization of the human right to water is seen as a political and social process that reenacts the social and ideological divides that permeate Guatemalan society. The author based this work on a documentary review of the political context of 2016, an analysis of the technical content of a selection of water law initiatives from this ime, and also by carrying out a series of key interviews in order to properly understand the underlying social dynamics that affect the initiatives that push for proper legislation on this matter.
Plaza de mercado del norte de Tunja
Authors: Sánchez Ríos Érika Johana
Published: May 2023

After the peace agreements formed between the Government and the FARC, the focus is now shifted towards the regions to work on: the territorial peace embodied in said negotiation; and a search for healing from the conflict in each area of the country. This research derives from the need to glimpse the role of women in Tunja towards the construction of peace in the country. It is sought to capture an x-ray of the social representation of women’s peace in Tunja, the capital city of the department of Boyacá. This population does not have a history of armed conflict but reports a high rate of domestic violence. Through the case study, a methodology is carried out to study the narratives that arise from working women from the northern market place, one of the scenarios that most commonly portray the Tunjana and Boyacense society. This study inquiry into the experiences, concepts, and stories related to their work and family life manages to identify what peace they are looking for, as well as the facts that do not provide them peace and the contributions that they can make from their context for the culture of peace they want to build.
Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics
Authors: Kumar Manish
Published: May 2023

Cancer is a complex disease involving the genome and has many aspects to
be considered including dysregulation of the epigenome to ensure
effective treatment of this deadly disease. The mutational changes
occurring in the regulatory genes responsible for maintaining optimal
cell growth and proliferation gradually lead to cancer development.
Importantly, patients with the same cancer types often respond
differently to different cancer therapies, indicating the need for a
patient-specific treatment option for cancer cure. Precision oncology is
the field of cancer research that essentially depends on the genetic
profiling of individual tumors to identify targetable alterations for
custom-tailored personalized treatment of the disease. It is to rely
upon the genomic study of cancer cells to get a clear picture of the
prognosis and pathways involved in disease progression and to look for
the means to selectively target them to achieve effective results.
Precision oncology thus combines cancer diagnosis and prognosis followed
by treatment regimen planning for precise treatment of the disease. This
article aims to briefly explain the foundations and frontiers of
precision oncology in the context of technological advances being made
in this direction to assess its scope and importance in the realization
of a proper cure for cancer.
Using UK/ASRM models and local model to predict the prognosis of IVF in China: a retrospective study.
Authors: Ren Jianzhi , Cai Jiali , Jiang Xiaoming , Liu Lanlan , Zhenfang Liu , Chen Jinghua , Chen Kaijie , Yang Xiaolian
Published: May 2023

Objective: To validate four pretreatment prediction models which were
developed based on UK/US population (McLernon 2016 model, Luke model,
Dhillon model, and McLernon 2022 model) and compare them with a model
developed based on local data. Design: Retrospective development and
validation of prediction models. Setting: University-affiliated hospital
Patient(s): A total of 26035 Chinese patients underwent OPU cycles
between January 2013 and December 2020. Methods: UK/US model performance
was externally validated. Local models were established with XGboost,
Lasso, and generalized linear model algorithms. Discriminatory power and
calibration of the models were compared. Main Outcome Measure(s): The
areas under the curves (AUC) of the Receiver Operator Characteristic
(ROC) and calibration curves. Result(s): The AUCs for McLernon 2016
model, Luke model, Dhillon model, and McLernon 2022 model were 0.68
(95% CI: 0.675-0.689), 0.67 (95% CI: 0.666-0.68), 0.685((95% CI:
0.678-0.692), and 0.673((95% CI: 0.666-0.68), respectively. The local
model yielded an AUC of 0.709(95% CI: 0.702-0.716) with key predictors
including age, duration of infertility, and endocrine parameters. All
external models suggested underestimation. Among the external models,
the rescaled McLernon 2022 model demonstrated the best calibration
(slope 1.12, intercept 0.06). Conclusion(s): A patient in China may find
the published pretreatment prediction models based on UK/US population
provide similar discriminatory power with reasonable AUCs and
underestimated predictions.
Spiro-isoxazolonechromans-3 alleviates LPS-induced acute lung injury in mice via inhibiting inflammation through modulating JAK1/STAT pathway
Authors: Zhang Yunhui , Xiong Baoping , Li Yue , Zhou Jing , Qiu Hongmei , Liu Hailin , Nie Yingqing , Gan Zongjie , Deng Ping , liu yingju
Published: May 2023

Acute lung injury (ALI) is a serious clinical disease with a mortality
rate of 30-40%. We designed and synthesized a structurally novel
compound, Spiro-isoxazolonechromans-3 (SI-3), to seek a new approach for
treating excessive inflammation in ALI. In the present study, we induced
RAW 264.7 cells with LPS and injected LPS intraperitoneally in BALB/c
mice to establish an ALI model. Molecular docking results showed SI-3
located in the hydrophobic pocket of Janus Kinase 1 (JAK1) and
interacted with JAK1 through amino acid residue Leu959. SI-3 selectively
inhibited the JAK1 enzyme activity with an IC50 of 9 nM and is
non-toxic. In vitro, LPS-induced macrophage proliferation, activation,
and secretion of inflammatory cytokines were inhibited by SI-3, which
promoted macrophage apoptosis. In vivo, SI-3 improved the survival rate
of ALI mice by reducing pathological lung injury and inflammatory
response. Both in vivo and in vitro, we discovered that SI-3 exerted a
downregulatory impact on the JAK1-STAT pathway according to the results
of western-blot studies and showed the same effect in
JAK1-overexpressing macrophages. Overall, SI-3 could reduce LPS-induced
inflammatory response and promote macrophage apoptosis by inhibiting
JAK1 kinase and affecting JAK1/JAK3-STAT pathway, resulting in
significant anti-inflammatory effects, which alleviated the LPS-induced
ALI in mice.
Is structural variation necessary to create islands of divergence in moderate gene flow species? A case study in sockeye salmon
Authors: Euclide Peter , Larson Wes , Shi Yue , Gruenthal Kristen , Christensen Kristen , Seeb Jim , Seeb Lisa
Published: May 2023

Local adaptation is often facilitated by loci clustered in relatively
few regions of the genome, termed genomic islands of divergence.
However, the mechanisms that create, mold, and maintain these islands
are poorly understood. Here, we use sockeye salmon as a model species to
investigate the mechanisms responsible for creating islands of
divergence linked to adaptive variation. Previous research suggests that
multiple islands are involved in adaptive radiation of sockeye salmon.
However, these studies were based on low-density genomic methods that
genotyped tens to thousands of loci, making it difficult to elucidate
the mechanisms responsible for islands. We used whole genome
resequencing to genotype millions of loci to investigate these
mechanisms. We discovered 64 islands, 16 of which were shared between
two isolated populations; these 16 islands were clustered in four
genomic regions. Characterization of the shared regions suggested that
three of four were likely created by chromosomal inversions, while the
other was created by processes not involving structural variation.
Additionally, all four regions were relatively small (< 600
kb), suggesting inversions and other low recombination regions do not
have to span megabases to be important for adaptive divergence. In sum,
our study demonstrates that heterogeneous selection can lead to a mosaic
of islands created by different mechanisms within the same genome.
Future studies should continue to investigate how gene flow, selection,
and the architecture of genetic traits interact to influence the genomic
landscape of adaptive divergence.
Protective effects of SS-31 on Post-Contrast Acute Kidney Injury in Diabetes Mice
Authors: hu jingyi , wu ziqian , Li Yanfei , Yao Xiang , Shi Dafa , zhang haoran , Ren Ke , guo qiu
Published: May 2023

Post-contrast acute kidney injury (PC-AKI) has emerged as the third
leading cause of iatrogenic acute renal failure. Diabetes mellitus not
only represents an independent risk factor for PC-AKI but also remains a
major cause of chronic kidney disease (CKD). SS-31, an antioxidant
peptide targeting mitochondria, is a potential preventive drug for
PC-AKI. In this study, we established a PC-AKI model by injecting
iodixanol in type 1 diabetic mice. Blood and tissue samples were
collected to confirm that iodine injection caused excessive reactive
oxygen species (ROS) in the kidney, activated the NLRP3 inflammasome
pathway, and subsequently aggravated the development of PC-AKI. We also
confirmed that SS-31 can reduce acute kidney injury induced by iodine
contrast agent in diabetes by protecting mitochondrial function and
inhibiting the ROS-NLRP3 signaling pathway.