bluuebunny/crossref_metadata_2025 huggingface dataset:
A study of bone marrow angiogenesis and its correlation with serum vascular endothelial growth factor levels in acute leukaemia
Authors: Yadav Neha , Kataria Sant P. , Kumar Sanjay , Vashishth Oshin , Atri Sudhir , . Mahak , Singh Sunita
Published: November 2022

Background: Angiogenesis, which is the development of new capillaries from existing blood vessels, occurs in both the developing embryo and postnatal life. The growth of solid tumours requires the development of micro vessels; therefore, tumour expansion correlates with the extent of angiogenesis.Methods: A prospective study was conducted on bone marrow trephine biopsies of 40 new cases of acute leukaemia diagnosed on complete blood count, bone marrow aspiration examination, and flow cytometry, including 20 control cases. Micro sections were stained with immuno-histochemical stains using monoclonal antibodies to CD31, CD34 and vWF. Micro vessel density was analysed at a 400× using automated image analyser by two investigators independently. Data were calculated, tabulated and statistically analysed using statistical package for the social sciences (SPSS) statistical program version 18.Results: A total of 1522 micro vessels were analysed using CD31 including 802 in acute myeloid leukaemia (AML), 512 in acute lymphocytic leukemia (ALL) and 208 in the control group. The bone marrow microvessel density (MVD) in acute myeloid leukaemia using CD31, CD34 and Von Willebrand factor (VWF) was 70.83±20.76, 66.48±18.99 and 60.32±18.75 respectively while MVD in acute lymphoblastic leukaemia was 62.74±21.09, 70.58±22.46 and 51.22±21.13 respectively. The study revealed significant difference between AML, ALL and normal bone marrow cases by using CD31, CD34 and vWF antibody. Serum vascular endothelial growth factor (VEGF) concentration in AML, ALL and control group was 163.74±119.03, 168.23±154.22 and 43.45±9.14 respectively.Conclusions: Higher micro vessel density was observed in acute leukaemia. Present findings suggested the potential significance of characteristics of micro vessel density as potential prognostic marker as well as its application in improved selection of patients for anti-angiogenic and other treatments.
Clinical and laboratory profile of tuberculosis in HIV positive individuals
Authors: B. Sandhya Rani , Bhandarkar Varsha R. , Nandalike Prathvi , Reddy Machandra
Published: November 2022

Background: Tuberculosis (TB), major public health problem in most of the developing countries. There is significant difference in the laboratory profile of tuberculosis in human immuno-deficiency virus (HIV) infected compared to immunocompetent host. Prompt diagnosis and treatment of tuberculosis in HIV infected will improve the morbidity and mortality associated with dual infection. Objectives of the research were: to study about the clinical profile of tuberculosis in HIV positive individuals; and also, to study about the laboratory profile of tuberculosis in HIV positive individuals.Methods: Patients with HIV positive status who fulfill the inclusion and exclusion criteria and admitted in Adichunchanagiri hospital and research center, BG Nagara Mandya district, Karnataka India, during the period of January 2020 to June 2021.Results: Fever was the most common symptom (92.8%). Most common manifestation was extrapulmonary TB (54%). TB meningitis was the most common extra pulmonary involvement seen in 28.67%. Amongst patients with pulmonary TB, 6.3% of cases were smear positive for AFB bacilli, 58% of cases had pulmonary infiltrates on chest X-ray. In all cases of extra pulmonary TB (EPTB) CD4T cell counts were <200 cells/μl.Conclusions: Chest X-rays were atypical with more of lowerzone infiltrative lesions. Sputum acid-fast bacillus (AFB) is negative in most of the patients with pulmonary TB, however had sputum cartridge based nucleic acid amplification test (CBNAAT) positive status, hence sputum CBNAAT remains the gold standard investigation. Fluid analysis with ADA correlation holds good for the diagnosis of TB meningitis and tubercular pleural effusion.
Assessment of study among radiography students about how to take informed consent
Authors: Kushwaha Vivodh , Singh Shilpa
Published: November 2022

Background: Consent form is an integral first step before any radiological procedure that engages methods that can be threatening to patients. Future radiographers i.e., radiography students should have sufficient and appropriate knowledge regarding obtaining an informed consent. The aim of my study is to evaluate and assess the knowledge and impart the importance of informed consent form among Radiography students under various conditions.Methods: A questionnaire based retrospective cross-sectional was used to assess the knowledge of informed consent among radiographic students. The study was carried out in radiology department of Maharishi Markandeshwar University. The questionnaire comprised of self-structured MCQs questionnaire consisted of demographic data and basic questions regarding informed consent.Results: Out of 156 undergraduate and postgraduate radiology paramedical students, 87 took part in the study. It was assessed how much information radiography students possess on taking informed consent. The gender ratio was allocated into 2 groups. First group was female consisting of 45 (51.72%) number of participants and second group male consisting of 42 (48.28%) number of students with mean of 21 years.Conclusions: Indulging on the subject of consent form, almost all of the students understood the concept of consent form or had heard about the concept of informed consent to some extent. Maximum students were in favour of classes being held discussing consent form. The statistical data of all participants who gave the correct answer is 81.20%, indicating that radiography students understand and grasp the concept of consent very well.
Study of local manifestations of snake bite and its surgical implications, at a rural hospital in India
Authors: Srivastava Shirish , Patel Vishwa , Rangwala Varin
Published: November 2022

Background: Manifestations of snakebite have local and systemic implications. While systemic manifestations can be life-threatening, local complications like cellulitis, necrosis, and compartment syndrome secondary to snakebite can threaten limb survival. This study undertakes the recognition of local complications and its outcome.Methods: A retrospective observational study was conducted at our tertiary center in India. 219 snake bitten patients presenting in between January 2013 to December 2020, were studied. Surgical interventions whenever required for managing local surgical complications were recorded and analyzed.Results: Of the 219 patients, 118 (53.88%) of the patients were bitten by venomous snakes requiring systemic therapy and 101 (46.12%) were non-venomous. Of the 118 patients with venomous snakebite, 78 (35.62%) had signs and symptoms. 83.11% reported to the hospital within 6 hours of the bite, while 45.66% within 2 hours. There were 169 (77.17%) patients who had local signs of inflammation, ischemic changes in 28 (12.79%), compartment syndrome in 15 (6.88%). 167 (76.26%) patients were treated conservatively while 52 (23.74%) had to undergo surgical interventions. Those undergoing surgical interventions had longer hospital stays (mean=8.09615) as compared to those treated conservatively (mean=4.82635) (p value=< 0.001). In patients with no local inflammation, only 1 (0.46%) required surgical intervention as compared to 51 (23.29%) (p value=< 0.001) patients with local inflammation requiring surgical intervention.Conclusions: Along with systemic medical treatment, local manifestations of most snakebites can be well managed with suitable surgical intervention. Surgical complications of snakebite are not infrequent leading to interventions. Such patients usually have a longer hospital stay.
The evaluation of the incidence of sensorineural component of hearing loss in chronic suppurative otitis media
Authors: Jha Shruti , Singh Rakesh Kumar
Published: November 2022

Background: The sensorineural component of hearing loss either in form of pure sensorineural or Mixed components has since long been suspected to be a dreaded sequela of chronic suppurative otitis media (CSOM). The aim of this study is to access the incidence of sensorineural hearing loss (SNHL) or mixed hearing loss (MHL) amongst people suffering from both mucosal and squamosal variants of CSOM.Methods: A prospective observational cohort study (control group: contralateral ear) was conducted at the E.N.T. department of tertiary care center from December 2020 to September 2022. 149 patients of ages 15-50 of either gender with unilateral CSOM were included in the study. The other normal ear of the same patient was taken as the control ear. The pure tone audiometry of both diseased and control ears at frequencies 500,1000,2000 and 4000 kHz were taken to determine SNHL or MHL.Results: The mean age was 26.54±8.75 years of which, 79 males and 70 females. The mean duration of disease was 3.92±3.32. SNHL occurred in 25.5% of cases, while conductive and MHL affected 69.8% and 4.7 % of patients respectively. Conclusions: SNHL and MHL occurred in a significant number of patients suffering from CSOM. Further research needs to be encouraged and management should be refined to decrease disease-related morbidity.
Pre-eclampsia and platelet indices: a cross sectional study
Authors: Khan Javid Ahmed , Ashraf Aadil , Qureshi Waseem , Fayaz Faizana
Published: November 2022

Background: Pre-eclampsia is a complex disease process originating at the maternal- fetal interface that affects multiple organ systems. The exact pathophysiology of preeclampsia is not known but it is considered to be associated with endothelial cell dysfunction, increased inflammatory responses and hypercoagulability. The receptors located on platelets are activated in pre-eclampsia by several proteases plus the vasoconstriction associated with preeclampsia leads to platelet activation which can be evaluated by platelet indices like platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and palteletcrit (PCT). The objective of this study was to compare the platelet count and platelet indices- MPV, PDW, and PCT in patients with pre-eclampsia and normotensive pregnant women.Methods: A cross sectional study which included a total of 204 patients divided into two groups (102 pre-eclampsia and 102 control. The patients were compared for platelet count and platelet indices like MPV, PDW and PCT.Results: The platelet count (PC) was decreased in pre-eclampsia group as compared to control group with statistically significant difference in means between the two groups (p<0.05). The MPV and PDW also showed significant difference between the two groups (p<0.05) with preeclampsia group having increased MPV and PDW values. The PCT value was lower in pre-eclampsia group as compared to control group but it did not reach statistically significant level.Conclusions: In pre-eclampsia patients while as MPV and PDW showed increased value as compared to control group and the difference between the two had statistical significance, platelet count was lower in them and had statistical significance when compared to control group. Therefore these platelet indices and platelet count can be used to predict and prevent complications arising from preeclampsia.
Traditional method or online teaching; which method students prefer: an observational study
Authors: Gayatri B. S. S. N. V. R. , Kishore S. Ravindra , Surekha Teki , Triveni Vanimina
Published: November 2022

Background: An unexpected global pandemic broke out in initial months of 2020 i.e., COVID-19 which drastically brought a difference in the progress of education in various institutions, especially the medical field where we study about life was also made online. This study aims to conduct a comparative analysis of students ‘opinion regarding which is the better, traditional teaching or online live teaching.Methods: Survey was conducted among two group of students, 2019 (both online and offline teaching) and 2020 (online teaching with offline practical) batches of Andhra Medical College, Visakhapatnam. A questionnaire was circulated to students regarding the class experience, interest of attending the class, learning effect and clarity of the lecture. Results: Students expressed their views that overall teaching experience and learning effect of offline methodology is superior to online approach, so the traditional offline style or the blend of online and offline modes are apt for teaching.Conclusions: The study is focused on the way in which the teaching and learning approach is delivered which is favoured by the medical practitioners, the qualitative data suggesting required modifications for further improvement in the delivering method to produce qualified medical practitioners to meet the current and imminent situations. This study suggests that a intermingled learning approach is an effective method for anatomy learning, and this approach mainly inculcates self-directed study through online learning.
Our experience with methyl alcohol poisoning at SLBSGMCH Mandi at Nerchowk
Authors: Kumar Nitesh , Bhawani Rajesh Kumar , Himral Pratibha , Lal Roshan , Dheer Santosh
Published: November 2022

Methyl alcohol poisoning is an extremely hazardous poisoning commonly occurs via oral ingestion of illicit or adulterated liquors or as ethanol substitution. Toxicity results in gastrointestinal manifestations, metabolic acidosis, neurologic squeal and even death. Rapid recognition, early and aggressive management have been emphasized to prevent hazardous outcome. We hereby present a case series of 16 cases who presented to our hospital as methyl alcohol poisoning. Demographic, clinical and biochemical data were collected retrospectively from the hospital record section of the tertiary care hospital in the state of Himachal Pradesh. Out of 16 patients admitted, 12 patients had metabolic acidosis and treated with sodium bicarbonate. Four patients underwent hemodialysis for the improvement of symptoms. Five patients with severe metabolic acidosis, hypotension and altered sensorium did not be recover and succumbed.
Electric injury: a case series
Authors: Sharma Naveen , Khanna Kunal , Dagar Tarun , Giri Sandeep K. , Pal Vijay , Kumar Kuldeep , Sharma Luv
Published: November 2022

In the modern era, electricity acts as a vital zone for mankind. The most important external sign of electrocution is the electric mark. The internal findings of electrocution are usually unspecific. The electric mark can also be of postmortem origin and is therefore not a reliable proof that the electric shock occurred before death, unless the survival time was long enough for an inflammatory response of the affected tissue. Various cases of electrocution have been reported in literature but as per the best of authors knowledge none of them have been clearly explained for the establishment of complete electric circuit in reported cases; required for fatal electrocution. In the present case series, authors’ report and discuss the three cases of electrocution under different circumstances with deviations in expectations. Because of the diagnostic problems authors also discuss the significance and careful evaluation of incident/death scene in all definitive as well as suspected cases of electrocution and emphasize on various components required for complete electric circuit for flow of current.
Vascular injury of the brachycephalic trunk from vascular access: case report
Authors: Sanchez Yankel A.
Published: November 2022

Central vascular accesses are very useful tools for the treatment and diagnosis of various medical conditions such as the administration of drugs and solutions, chemotherapy, hemodialysis, hemodynamic monitoring. A review of the clinical record of a 59-year-old patient treated at a tertiary hospital was performed. We presented the case of a patient with vascular lesion of the brachiocephalic truncus arteriosus derived from the placement of a dialysis catheter. Vascular access placement is a routine procedure in many critical patient services, however it is important to know in detail the vascular anatomy and surgical technique to reduce the risk of complications.
Time to think beyond sickle cell screening and haemoglobin electrophoresis: a case report and review of literature of sickle cell D-Punjab falsely labelled as sickle cell SS from central India
Authors: Vyawahare Milind , Vandana Vandana , S. Tony K. , Shah Kunal , Thakur Ayush
Published: November 2022

Sickle cell haemoglobin D disease (D-Punjab) is a rare variant of sickle cell disease (SCD) reported from central India. Exact incidence of pulmonary thrombosis in patients with HbSD is unknown. Pulmonary thrombosis is known complication of SCD but rare in case of HbSD pattern. We reported a case of 34-year-old male patient with HbSD (D-Punjab) with acute chest syndrome (ACS). CT pulmonary angiogram revealed near complete thrombosis of right middle lobe segmental and subsegmental branches with pulmonary infarct. Our patient responded to anticoagulant therapy. This case report is a reminder that HPLC should be done in all patients with sickle cell disease along with solubility test and hemoglobin electrophoresis to detect exact incidence of hemoglobin D disease in central India.
Hypoxic bradycardia: an enigma in coronavirus disease 2019
Authors: Kapoor Ruchi , R. Lakshmi , Devaraj Ganga Dutt , Mohan Aparna
Published: November 2022

Coronavirus disease 2019 varies from asymptomatic to severe acute respiratory syndrome with multiple organ involvement, primarily involving the microvasculature and heart. Acute myocardial injury is the most frequently observed and reported cardiac complication with acute coronary events, acute left ventricular systolic dysfunction, and cardiac arrhythmias, but sinus bradycardia reported only in a few cases. The development of sinus bradycardia can be crucial warning sign of onset of severe cytokine storm. The primary determinant of severity of COVID-19 is aging and co-morbidities such as diabetes and hyperlipidemia with dysregulated immunological status. Patients with pre-existing cardiovascular disease infected with COVID-19 have increased risk of severity and mortality. Literature available regarding the occurrence of bradycardia is limited, and electrophysiology studies in COVID-19 patients have shown sinus bradycardia, heart block, bundle branch block, and intraventricular conduction delay. The pathophysiological mechanism regarding the occurrence of bradycardia is not yet known entirely. Cardiac manifestations could be attributed to multiple clinical etiologies, including direct viral myocardial damage, inflammatory response, hypoxia, hypotension, downregulation of angiotensin-converting enzyme 2 (ACE-2), drug toxicity, and endogenous toxicity of catecholamine adrenergic status, also severe hypoxic damage of lungs by COVID-19 can also act as a trigger. We report one such case of bradycardia due to COVID-19 detected through intensive monitoring and managed successfully in the ICU of tertiary care dedicated COVID-19 hospital. Bradycardia in COVID-19 is a rare clinical phenomenon, could be a worst prognostic marker. If detected early may help in prognostication and, if managed appropriately, will avert a life-threatening complication.
An unusual cross reactivity between hydrochlorothiazide and para-phenylenediamine: a case report
Authors: Patil Deena , Sumathy Tharayil K. , Anuradha Hassan V.
Published: November 2022

Over the last decade, the usage of hair color is gradually increasing from adolescents to the geriatric population. In the elderly population, more use of hair color due to graying of hairs exposes them to chemicals such as para-phenylenediamine (PPD). Many cases are reported regarding various manifestations of allergic contact dermatitis due to PPD compound present in hair color. It is noteworthy that, in the elderly the use of antidiabetics and antihypertensives, makes them vulnerable to cross-reaction or interaction with drugs and chemicals. We report a case that highlights the adverse reaction to hydrochlorothiazide in a PPD sensitive individual.
Primary empty sella syndrome presenting as adrenal insufficiency and without raised intracranial tension
Authors: Gupta Ishank , Panchalwar Vinay , Chabra Aman
Published: November 2022

Empty sella syndrome (ESS) based on pathophysiology can be either primary empty sella syndrome (PES) or secondary empty sella syndrome (SES). Patients of PES have no known pituitary pathology and have varying degrees of pituitary gland flattening. We present a 65-year-old female who came with complaints of generalised swelling over the body, generalised weakness, altered sensorium and low-grade fever. Patient had history of ischaemic heart disease 3 years back without any other known co-morbidities. Patient presented in hypoglycaemia and hypotension with facial puffiness and oedema feet with basal crepitations indicating fluid overload state. Patient was stabilised and evaluated. Patient was found to have hyponatremia and urinary tract Infection and associated acute kidney injury. Patient’s morning cortisol and adrenocorticotropic hormone (ACTH) levels were also low with associated low insulin-like growth factor 1 (IGF-1) and normal thyroid stimulating hormone (TSH) levels but low T3 and low T4 levels. Patient’s magnetic resonance imaging (MRI) brain was done which was suggestive of PES. The cause of empty sella remained unclear but the adrenal insufficiency was treated with hydrocortisone and the patient became asymptomatic and was discharged subsequently.
Giant umbilical hernia case report and literature review
Authors: Sanchez Yankel A. , Garcia Diana L.
Published: November 2022

Umbilical hernia is a defect of the abdominal fascia that allows the protrusion of the intestinal content through the umbilical ring, in adults these hernias are associated with increased intra-abdominal pressure caused by obesity, abdominal distension, and abdominal distension. We presented the clinical case of a 38-year-old female patient who presented a giant umbilical hernia with contents of the transverse colon and necrotic ascending colon, performing abdominal wall plasty with separation of components. Treatment of patients with giant hernias is a challenge. The presence of non-viable bowel should not be considered a contraindication for mesh repair. Giant umbilical hernias are an uncommon pathology which requires knowledge of the different techniques of abdominal wall repair as well as their possible complications.
Role of insulin resistance and insulin action in polycystic ovary syndrome: a concept review
Authors: Kumari Kirti , Babbar Assem , Joshi Yogesh
Published: November 2022

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine-metabolic illness that has alarmingly high rates of infertility and other significant effects on the health of women. This review study highlighted that Insulin appears to damage every part of the hypothalamus-hypophysis-ovary axis, and insulin resistance in ovarian tissue leads to impaired metabolic signalling but intact mitogenic and steroidogenic activity, favouring hyperandrogenemia, which is thought to be the primary cause of the clinical symptoms of PCOS. This review also enumerates and briefly summarize the research methods related to effects of insulin resistance in PCOS, including molecular mechanism of action of insulin and anabolic processes that stimulate cell growth and differentiation; increase protein and fat storage; and the binding between α, β dimers and receptors on cell surface that results in alteration in gene expression, metabolism and growth.
Applying sex as a biological variable in research and clinical care: a need for uniform policy
Authors: Hussain Masaraf
Published: November 2022

Sex as a biological variable (SABV) has to be recognized in both preclinical (basic) and clinical research, as a major contributor to disease risk, phenomenology, natural history, treatment and adverse effects, and disease severity.
X-linked agammaglobulinemia: 35 years of experience in a tertiary pediatric hospital in Latin America
Authors: Cardenas-Cruz Cristopher , Jiménez-Santana Lizeth , Campos-Lopez Diana E. , Espinoza-Coria Celeste , Pérez-Correa Paola A. , Mendoza-Arias Alejandro , B. Luis D. Mendoza , González S. M. Edith
Published: November 2022

Background: X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by arrested B cell development, leading to reduced numbers of B lymphocytes and serum immunoglobulin (Ig) levels, due to mutations in the BTK gene located on the X chromosome (Xq21.3- Xq22). The aim of this study was to describe the clinical and immunologic characteristics of patients with a diagnosis of XLA, seen in a tertiary pediatric hospital in Mexico in the department of immunodeficiency in the last 35 years.Methods: A cross-sectional, retrospective and observational study of patients diagnosed with XLA with follow-up in a reference hospital in Mexico City, in a period of January-1987 to July-2022 was performed, data related to their disease status were taken and statistical analysis were analyzed using SPSS.V.16.0.Results: Information was collected from 44 patients with the diagnosis of XLA. The age of onset was 24 months. The age at diagnosis was 60 months. A delay in diagnosis of 37 months was identified, 54 % of patients required I.V. antibiotics before diagnosis, and 45% had a family member with immunodeficiency. The mean Ig levels were IgG: 359 mg/dl, IgA: 24 mg/dl, and IgM: 25 mg/dl. The 77% had a history of bacterial infections before diagnosis, and 6% had allergic symptoms. The main infection was pneumonia in 75%, acute otitis media in 50%, sinusitis in 59%, meningitis in 13%, cutaneous abscesses in 15%, 36% percent developed complications such as bronchiectasis, and 31% sepsis. Once the diagnosis was established, all patients received Immunoglobulin replacement therapy (IRT). 47% of patients were administered antibiotic prophylaxis.Conclusions: The diagnosis of XLA should be suspected in a patient with recurrent clinical manifestations of encapsulated bacterial infections. The diagnosis is confirmed with serum immunoglobulin levels, two standard deviations below for age, when the flow cytometry is available it can help with the diagnosis. The first contact physician can make the diagnosis.
Ozenoxacin: A novel topical quinolone
Authors: Shirsat Amar , Shah Bela , Trailokya Abhijit
Published: November 2022

The burden of dermatological conditions is huge on the global health accounting for 44.1 million DALYs worldwide. Impetigo is a highly contagious bacterial infection with 2.5 time’s greater likelihood in pediatrics (12.3%) than in adults (4.9%). Micro-organisms causing impetigo include bacteria like or both. The management of Impetigo is with topical and systemic antimicrobial agents. Topical antimicrobial resistance is on the rise in patients with Impetigo. Therefore, there is clearly a need for newer antimicrobials having different mode of action and showing good activity against non-responding strains in the management of impetigo. Ozenoxacin is a novel, topical quinolone with a good safety and tolerability profile in the management of Impetigo. The authorizing bodies namely USFDA, European Medical Agency, and DCGI have approved the use of Ozenoxacin 1% cream for the topical treatment of impetigo due to in adult and pediatric patients 2 months of age and older.
Is the targeted approach for vitiligo satisfactory?
Authors: Chaudhry Sunil , Manmohan G , Bhanavath Swathi
Published: November 2022

Vitiligo is also known as Safed Daagh, Safed Kodh, Phuleri and Savitra in vernacular. Vitiligo causes social and psychological distress, affecting 0.1 to 2 Percent global population. The pathology demonstrates depigmentation of the skin, with loss of melanocytes by autoreactive cytotoxic T cells. The vitiligo-infiltrating lymphocytes were T lymphocytes, and most were CD8+The elevated levels of H2O2 in the skin mediate the production of proinflammatory cytokines like IL-1β, IL6, and IL-8 indirectly by activating the calreticulin pathway. Autoimmunity in vitiligo is driven by the IFN-γ-CXCL10 cytokine (motif chemokine ligand) signaling pathway. No drug can stop the process of vitiligo. Most of the drugs are used in combination. Light therapy can help to restore some color. Topical steroids, calcineurin inhibitors, and narrow-band ultraviolet (UV)–B phototherapy are widely used. New depigmenting therapies are emerging such as helium-neon (He–Ne) lasers and prostaglandin E2 analogs. In cases of stable disease, surgical procedures such as skin grafting, blister grafting, orCellular suspension transplant are often tried. Ruxolitinib is the first medication that can restore pigment in patients with nonsegmental vitiligo. Tildrakizumab is also being evaluated in form of Topical Cream. Unfortunately, vitiligo is life long condition which is difficult to treat with satisfaction.
Psychocutaneous manifestation in psoriasis
Authors: Thomas Jayakar , Ramamurthy Pradeepa
Published: November 2022

Psoriasis is a chronic hyperproliferative condition of the epidermis which requires systemic therapy. Anxiety, depression, poor self-esteem, alcoholism, sexual dysfunction, suicidal ideation are the commonest psychological problems encountered in psoriasis. Quality of life may be severely affected by the chronic nature of the psoriasis as well as the need of life long treatment. In general, psychological factors include poor self-esteem, stigmatization, depression and anxiety which are the strong determinants which determine the disability in psoriasis more than the disease itself. This is a review article highlighting on the psychological aspects of psoriasis.
Role of intralesioal Vitamin D in treatment of cutaneous warts
Authors: Munshi Noreen , Varma Krishnendra
Published: November 2022

The majority of treatments for skin warts include destructive techniques like electrocautery and cryotherapy. These techniques of treatment frequently result in recurrence and scarring. Examining the safety and efficiency of intralesional vitamin D3 injection in cutaneous warts is the goal of this study.

Total 50 people with recalcitrant warts of different dimensions, frequencies, and longevity participated in the study. 0.2 to 0.5 ml of vitamin D3 (600,000 IU, 15 mg/ml) were injected into the bases of warts. A maximum of 5 warts were administered per session, with sessions occurring every 2 weeks till the warts vanished, or for a total of 3 sessions. Following the final injection, individuals were monitored for six months to look for any recurrence.

The trial was completed by 50 patients. Out of 50 patients, 35 (or 70%) showed a complete reaction, five (10%) showed a partial response, and ten (10%) showed no response. In every case, the distant warts completely disappeared.

A safe, effective, and affordable therapy option for resistant warts is intralesional vitamin D3.
Efficacy of autologous platelet-rich fibrin (PRF) in management of non-healing ulcers in Hansen’s disease
Authors: Agrawal Somya , Varma Krishnendra , Kumar Ujjwal
Published: November 2022

Non-healing ulcers are a major cause of disability and impairment, interfering with physical and mental well-being of patients with Hansen’s disease. They are difficult to manage having longer duration of treatment and increased financial burden. Minimizing the duration of healing can be a major step in rehabilitation of such patients. Platelet rich fibrin (PRF) is a newer modality to hasten wound healing. It is a concentration of platelets suspended in plasma extracted after centrifuging patient’s own blood.

: To study the efficacy of platelet-rich fibrin (PRF) in management of non-healing ulcers.

: 13 patients with 16 non-healing ulcers of more than 8 weeks duration were included in our study but 2 patients were lost to follow up after first sitting. Written consent for the procedure and ethical clearance from Institutional Ethical Committee was taken. Detailed history was noted, baseline photographs and measurement of area and volume were done at every sitting at an interval of 1 week. An average of 2-3 sittings of PRF was done in each patient and then the ulcer was spontaneously allowed to heal with regular dressing till complete closure was achieved.

: The mean age of cases in our study was 39.4 years. The average percentage improvement in area and volume was 97.12% and 98.72% respectively. Out of 14 ulcers, 12 (85.71%) ulcers showed complete healing within 4 weeks. The mean duration of healing was found to be 2.41 weeks. The procedure was safe with no noted adverse events.

The limitation of our study was small sample size. More studies are needed with larger sample size to confirm the results.

: PRF is an inexpensive, safe, feasible and effective procedure in the management of non-healing ulcers.
A rare case report of AEC syndrome, Ankyloblepharon, ectodermal dysplasia and cleft LIP/cleft palate
Authors: Sree Kalle Gauthami , Aishwarya N , Lakshmi P Vijaya
Published: November 2022

The AEC syndrome or Hay wells syndrome is an unusual autosomal dominant disorder characterised by Ankyloblepharon, Ectodermal dysplasia and Cleft palate and/or Cleft lip. This syndrome occurs as a result of missense mutation in TP63 affecting P63 SAM of the gene, which is a protein-protein interaction domain. It is associated with some irregularities like Cleft palate /Cleft lip, severe scalp erosions and abnormalities of epidermal appendages including hypotrichosis, hypodontia, absent or dystrophic nails & mild hypohydrosis. We, here by report a case of full term baby born to third degree consanguineous parents with features of cleft lip and cleft palate, multiple erosions present over back, alopecia over left side of scalp along with few erosions over right side of scalp, sparse eye brows & eye lashes, Ankyloblepharon, Microphallus, Dystrophic finger and toe nails due to its rarity. Diagnosis is made commonly by clinical examination and Genetic analysis.
A 17-year-old male presenting with multiple hyperpigmented macules over right side of chest in zosteriform pattern
Authors: Mohan Atul , Rai Tulika , Ansari Mohammad Hamza , Goyal Deeksha
Published: November 2022

Lichen planus pigmentosus (LPP) is a variant of lichen planus. It is characterized by small black, brown macules, on sun exposed areas like face, neck, upper extremities and trunk. Lesions are insidious in onset with gradually progressive course. Few variants have been reported like LPP inversus, localized LPP, linear LPP, zosteriform LPP and LPP of oral mucosa etc. Here, we present a case of zosteriform LPP in a young adolescent male, which is a rare presentation.
Zosteriform lichen planus after healed herpes zoster: Report of a new case of Wolf\'s isotopic phenomenon
Authors: Munshi Noreen , Varma Krishnendra
Published: November 2022

"The wolf isotopic phenomenon corresponds to the appearance of a skin disease in a place on the body that was previously affected by another, already healed dermatosis." A 35-year-old woman presented with a transversely distributed zosteriform eruption about 12 to 14 cm in length, consisting of erythematous, scaly, moderately pruritic papules on the left flank that spread to the back (does not cross the midline) for several weeks after locally healed herpes zoster (HZ) lesions. No other skin or mucosal sites were included. Routine examination of blood, urine and stool showed no abnormality. A biopsy sample was taken from one of the lesions. Histopathological examination showed typical lichen planus changes, confirming the diagnosis of post-Herpes zoster zosteriform lichen planus (ZLP). The lesions resolved after treatment with topical steroids. Zosteriform lichen planus (ZLP) is an example of a Wolf isotopic phenomenon appearing after HZ at the same site. The exact pathogenesis of ZLP is unknown, it is assumed that persistent viral proteins could be responsible for the hypersensitivity reaction.
An acantholytic variant of dowling degos disease
Authors: Kapoor Sheena , Kharkar Vidya , Rathod Dipali
Published: November 2022

Galli- Galli disease is a rare acantholytic variant of Dowling- Degos disease, with few cases reported in the literature till date. We here, describe an interesting case of Galli- Galli disease with prominent histopathological findings. Future studies and genotype-phenotype correlations may elucidate why acantholysis is observed in some patients, but not in others.
Prevention of noise-induced hearing loss by rational appointment algorithm in periodontal, restorative and prosthetic treatments: A method study
Authors: Burak Ak  , Emre Gürkan Eroglu
Published: November 2022

Dentists are at risk of noise-induced hearing loss (NIHL). Dental treatment equipment has high-intensity noise levels. Occupational noise levels of multi-unit dental clinic are higher than private clinic and are at further increased risk of NIHL. This study aims to develop a noise-reducing appointment system in multi-unit dental clinics using treatment duration and steps noisemap. Restorative, periodontal, and prosthetic dental procedure noise levels were measured in a multi-unit dental clinic. A procedure noise map was created by measuring the amount of noise in the treatment time interval and the silent treatment period. The appointment algorithm was created according to this noise map. Control and 7 test simulation appointment algorithms were tested. The control group was simulated in six units simultaneously with conventional hour-based appointment algorithm. Test groups were simulated according to the appointment algorithm based on the treatment steps noisemap. Six-unit dental clinic was simulated under the dBmap system. While 2 of the 6 units in the test groups are in noise producing treatment steps, the other 4 seats are planned to operate without noise. According to treatment steps noisemap, test groups operated two-unit simultaneously at different timings. The distribution of noise producing units in the clinic was simulated in 7 groups (T1-T7). The mean noise measurements in all tested groups were significantly lower than in the control group. Periodontal treatment mean occupational noise level (68 dB) was higher than restorative (61 dB) and prosthetic treatment (59 dB). Control room mean occupational noise measurement was 68,54 dB, and test groups mean occupational noise measurements were between 57,19 –63,98 dB. The difference between control and tested groups was significantly different(p=0,0009). Occupational noise was significantly reduced with the noise reduction-based appointment method. Further studies are needed with different treatment procedures and validation studies in clinical settings.
Comparison of efficacy of 0.05% sodium hypochlorite with 0.2% chlorhexidine as A pre-procedural mouthrinse in periodontitis patients
Authors: Sinha Amit , Anamika  , Aarya Adity , Sinha Goldi , Verma Neha , Nabi Aaysha Tabinda
Published: November 2022

: The objective of the study is to compare the efficacy of 0.05% sodium hypochlorite and 0.2% chlorhexidine as a pre-procedural mouth rinse for routine periodontal procedures to reduce the amount of aerosols containing infectious agents.

A study was designed to be conducted on patients reporting to the outpatient department of Periodontology at Buddha Institute of Dental Sciences & Hospital, Patna. Patients with generalized severe chronic periodontitis were divided into 3 groups. 15 patients were made to rinse with 0.05 % sodium hypochlorite for 1 minute, (Group A), 15 patients with 0.2% chlorhexidine (Group B), and 15 patients with normal saline (Group C) for 1 minute before routine ultrasonic scaling procedure. A blood agar plate exposed at 20 inches from the patient’s oral cavity was used for microbial sampling. It was incubated at 27°C for 24 hours and colony forming units (CFUs) were counted thereafter.

: There was statistically significant differences in the number of CFUs of the different groups.

: Both 0.05% sodium hypochlorite and 0.2% chlorhexidine were effective in reducing aerosol contamination during ultrasonic scaling but 0.05% sodium hypochlorite had a significantly better effect than 0.2% chlorhexidine.
Evaluation of Nd: YAG laser as an appurtenance to scaling and root planning in treating chronic periodontitis
Authors: Yadav Rakesh Kumar , Verma Umesh Pratap , Tiwari Rini
Published: November 2022

Chronic Periodontitis (CP) causes inflammation of teeth’s supporting tissues and progressive loss of bone and attachment. The purpose of this study was to compare the treatment methodology for CP using Scaling and Root Planning alone and in combination with Nd: YAG Laser.

: Sixty patients diagnosed with generalized moderate chronic periodontitis were randomly assigned to two different groups. Group 1: SRP, group 2: SRP and Nd: YAG Laser. A clinical examination of Plague Index PI, Gingival Index GI, and Probing Pocket Depth PPD was performed on each patient. Four follow-ups were conducted: at baseline, at one month, at three months, and six months.

A gradual reduction was seen in PI, GI, and PPD in both groups, but significant effects were observed in group 2 patients. In group 2, the PI had a more considerable F value of 291.22 and was more substantial than the control group.

It can be concluded that although SRP is a conventional technique for Chronic Periodontitis but when combined with non- surgical laser treatment it provides with prolonged benefits.
Polycythemia vera: Gingival and periodontal manifestations and management – A case report
Authors: Madhavan Sanupa S , Alex Timy S , Alex Tiny S , Narayanan Anjhana
Published: November 2022

Polycythemia vera is a rare case confronted in dentistry with scarcely available case reports. Hence a scrupulous knowledge of it is inevitable. It is a myeloproliferative disorder characterized by excessive proliferation of erythroid elements, granulocytic and megakaryocytic cells. Here, the blood viscosity increases leading to menace of thrombosis. The medications often used include cytoreductive agents like hydroxyurea 500mg to reduce the leukemogenic risk and Ecospirin 75mg to lessen the thrombotic risk in artery.

A 44-year-old male patient reported with a history of pain over the upper right back tooth region since two weeks. The pain was sudden in onset sharp intermittent non radiating aggravates on taking cold fluids and relieves by itself. He also complained of food lodgement around the same site. He is a known case of absolute polycythemia in the last 8 months, undergoing treatment with Ecospirin 75mg and frequently subjected to phlebotomy.

A synchronized endeavour by hemato-oncologist and dentist is required for dental treatments, peculiarly invasive therapies, in such patients. Further, an awareness of the medication used for the treatment is unavoidable.
Splitting for good: A case report
Authors: Kamboj Ashish , Awchat Kiran L , Wadhwa Vinay , Chopra SS , Angrish Paras , Sinha Nishant
Published: November 2022

: The bone split procedure is a unique technique used to increase the width of narrow ridge for possible simultaneous implant placement.

: We would present a case of horizontal ridge augmentation in this article, using an alveolar ridge expansion approach and simultaneous implant placement.

: In this report, we have described a ridge split technique and immediate implant placement for a 40-year-old male patient with missing teeth in maxillary anterior tooth region who reported to us for implant treatment

: A successful prosthetic rehabilitation was obtained following the healing phase. This approach leads to restoration of aesthetics, function and speech with a predictable outcome.
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway
Authors: Xie Zikang , Wang Bin , Zheng Chong , Qu Yuxing , Xu Jianda , Wang Bin , Gao Yi , Shen Pengfei
Published: November 2022

Osteoarthritis (OA) has a high incidence rate in the elderly population and is a cause of chronic degenerative joint disease. Current therapeutic approaches to OA are effective but come with some side effects. Therefore, it is urgent to find new safe and effective OA treatments. This study aimed to clarify the function of taraxasterol (TAX) isolated from Taraxacum officinale in the papain-induced rat OA model. We observed that TAX alleviated the typical OA-caused phenomena in the joint. The expression of serum inflammatory mediators such as TNF-α, IL-6, and IL-1β was also repressed by TAX. In addition, NF-κB signaling pathway was repressed by TAX. Furthermore, two microRNAs: miR-140 and miR-146a were elevated after TAX treatment in OA rat model. Interestingly, several common targets of miR-140 and miR-146a, including HSPA4L, ST5, and ERBB4, were confirmed to be regulated by TAX. Inflammatory response related genes including S100A8, CCL3, A2M, LBP, and CCR1 were repressed by TAX in OA rat model. In summary, TAX inhibits inflammation in osteoarthritis rat model. Inflammatory mediators, NF-κB pathway and miR-140/miR-146a targets mediate the function of TAX.
A Country’s Economic Growth and Rankings of Higher Education Institutions: Is There a Relationship?
Authors: Dreval Olga , Martynets Viktoriya , Opanasiuk Yuliia , Pavlenko Olena
Published: November 2022

The components of the chain of influence of the HEI ranking on the economic growth of the country are studied in the article. The relation between the keywords university, rankings and economic was found based on the bibliometric analysis. Based on correlation and regression analysis, there has been proved the relation between the components of interaction in the chain: Total overall ranking score of universities in the country – number of FTE students enrolled in country’s rated HEIs – number of country’s rated Universities – GDP of the country. The confirmation of the obtained calculations is a questionnaire survey carried out among the students of the HEIs. The results of the questionnaire survey indicate the existence of the influence of the HEI ranking on the number of students enrolled in educational institutions of the studied country. Thus, based on correlation and regression analysis and sociological research, the article proves the hypothesis about the existence of the influence of the HEI ranking on the economic growth of the country.
State Modeling Methodology for Business Processes
Authors: Myslín Josef , Kaiser Jiří
Published: November 2022

In many areas of human activity, process modeling is perceived as a necessity, in some, it is even defined as an integral part of this activity. This fact showed that contemporary approaches to process modeling are, in some cases, not capable of describing the process with all its nuances. This paper defines a new paradigm (and subsequently a new process modeling methodology) that will suitably complement the existing paradigms. This is a state paradigm understanding the process as a transition between states. Such a concept of the process can, in some cases, enable the creation of a model that will better answer the questions asked.
Professional Training of Emerging Fuel and Energy Industry Professionals Based on Factor Analysis
Authors: Kozlov Anatoly , Lapteva Svetlana
Published: November 2022

The development of mathematical competencies and the ability to apply mathematical modeling is one of the key aspects of training engineering experts. The study showed a statistically significant increase in the objective assessment of knowledge in the experimental group compared to the control one (8.12 – 7.56 points on a 10-point scale in the experimental group and 5.15 – 6.68 points in the control one). The largest possible standard deviation in the study is 0.72, which indicates the statistical significance of the results obtained. The proposed methodology differs from the most commonly used design and modular methods in integrity and consistency.