bluuebunny/crossref_metadata_2025 huggingface dataset:
Tinjauan atas Retinopati Valsalva
Authors: Priyantono Rabiul , Meylani Nassa Rachmatika
Published: July 2022

Retinopati Valsalva adalah penyakit dengan gambaran perdarahan lapisan subhyaloid atau sub-Internal Limiting Membrane (ILM) retina yang disebabkan oleh aktivitas mirip manuver Valsalva seperti batuk, mengejan, muntah, atau latihan fisik yang kuat. Keluhan berupa penurunan tajam penglihatan mendadak mulai dari ringan sampai berat, bahkan hilangnya tajam penglihatan. Penyakit ini belum diketahui epidemiologinya. Perdarahan bisa mengalami resolusi dalam beberapa minggu atau beberapa bulan. Tindakan laser atau pembedahan dibutuhkan jika perdarahan cukup banyak atau tidak terjadi resolusi.

Valsalva retinopathy is hemorrhage in subhyaloid or sub-Internal Limiting Membrane (ILM) layer in retina, caused by Valsalva maneuver-like activity such as cough, straining, vomiting, or vigorous physical activity. The symptom is mild to severe sudden painless decreased visual acuity, even loss of vision. The epidemiology of this disease is unknown. Hemorrhage in retinal layer can be resolved in weeks to months. Laser treatment or surgical treatment can be considered if in massive hemorrhage, or no resolution after observation.

 
Iktiosis Harlequin: Tatalaksana dan Prognosis
Authors: Gunawan Harry , Rakhmawati Flora Anisah
Published: July 2022

Iktiosis Harlequin (IH) merupakan kelompok iktiosis kongenital autosomal resesif yang sangat jarang terjadi, dengan prevalensi 1 kasus setiap 300.000 orang. IH memiliki manifestasi klinis tipikal, dilahirkan dengan hiperkeratosis masif yang disebabkan pewarisan gen autosomal resesif mutasi gen adenosine triphosphate (ATP) - binding cassette sub-family A member 12 (ABCA12) yang terlibat dalam sekresi granula lamelar, serta transport seramid dan lipid epidermal. Kemungkinan hidup pasien IH meningkat seiring perbaikan fasilitas perawatan neonatus dan terapi retinoid. Prinsip utama perawatan pasien IH adalah mengupayakan deskuamasi, terapi suportif, dan penanganan kecacatan fisik yang mengancam vitalitas organ. Konseling genetik dan pemeriksaan diagnostik prenatal perlu untuk deteksi dini pada keluarga yang memiliki riwayat IH.

Harlequin Ichthyosis (HI) is a rare autosomal recessive congenital ichthysosis that occurs in about 1 in 300.000 people. HI is characterized by typical skin manifestation with massive hyperkeratosis due to adenosine triphosphate (ATP) - binding cassette sub-family A member 12 (ABCA12) gene mutation inheritance. The ABCA12 gene is involved in lamellar granule secretion, ceramide, and epidermal lipid transport. Survival rate of HI patient increased along with improvement of neonatal care facilities and administration of systemic retinoid. The main principles of care are desquamation, supportive therapy, and treatment for physical disabilities which threatens organ vitality. Genetic counseling and prenatal diagnosis could benefit family with HI history.

 
Sudden Onset of Strabismus in Adults-Is It a Life-Threatening Sign?
Authors: Dewi Amita Angela Shinta , Faustine Giovani
Published: July 2022

The overall incidence of strabismus is higher in adults; approximately 1% of children have strabismus, while the estimation among adults is 4% but may run as high as 5.6%. The four types of new-onset strabismus in adults most often found were paralytic, convergence insufficiency, small-angle hypertropia, and divergence insufficiency. The stroke should be suspected in the sudden onset of paralytic strabismus. The most prevalent type of manifest strabismus found on stroke survivors was exotropia. Tumors, myasthenia gravis, thyroid eye disease are common causes of gradual-onset strabismus. Thorough examinations and proper referral are needed.

Insidens rata-rata strabismus lebih tinggi pada dewasa; sekitar 1% populasi anak mengalami strabismus, sedangkan perkiraan prevalensi strabismus dewasa sebesar 4%, dan dapat mencapai 5,6%. Empat tipe strabismus onset baru pada dewasa yang paling sering adalah paralitik, insufisiensi konvergen, hipertropia sudut kecil, dan insufisiensi divergen. Salah satu penyebab paralitik yang harus diwaspadai adalah stroke. Eksotropia merupakan tipe strabismus yang paling sering pada pasien post-stroke. Tumor, miastenia gravis, penyakit tiroid pada mata merupakan penyebab umum kasus strabismus onset lambat. Pemeriksaan menyeluruh dan sistem rujukan yang baik diperlukan untuk terapi yang memuaskan.
Hemofilia dan Perkembangan Terapinya
Authors: Lawrenti Hastarita
Published: July 2022

Hemofilia A dan B adalah gangguan perdarahan yang diturunkan yang ditandai dengan defisiensi protein koagulasi faktor VIII dan IX. Terapi pengganti dengan faktor pembekuan (konsentrat faktor VIII atau IX dari plasma atau rekombinan) masih merupakan terapi hemofilia baik saat perdarahan maupun sebagai profilaksis. Terapi profilaksis merupakan terapi standar untuk pasien hemofilia berat karena dapat mencegah kerusakan sendi, menurunkan frekuensi perdarahan sendi dan lainnya, serta memperbaiki kualitas hidup. Keputusan memilih terapi harus berdasarkan pertimbangan medis dan klinis, dan bersifat individual.

Hemophilia A and B are inherited bleeding disorders characterised by deficiency of coagulation protein factor VIII and IX, respectively. Replacement therapy with clotting factors (factor VIII or IX through plasma-derived or recombinant concentrate) is the mainstay of treatment at time of bleeding or as prophylactic based on individual needs. Prophylaxis treatment is standard treatment for patients with severe hemophilia as it prevents joint damage, reduces frequency of joint and other bleeding and improves quality of life. Choice of therapy should be based solely on medical and clinical considerations and individualized.

 
Aspek Imunitas pada COVID-19
Authors: Nitiyoso Nugroho
Published: July 2022

Gejala COVID-19 sangat bervariasi dari ringan hingga berat. Selain faktor komorbiditas, reaksi imun yang berbeda-beda antar pasien juga menjadi faktor yang memengaruhi berat-ringannya gejala COVID-19. Kenaikan kadar sitokin diduga menjadi faktor yang memperberat gejala COVID-19. Dalam artikel ini, akan dibahas aspek respons imun serta sitokin yang memengaruhi gejala COVID-19, serta beberapa pengobatan imunologi yang sedang diteliti untuk COVID-19.

Symptoms in COVID-19 patients vary widely from mild to severe. In addition to comorbidities, different immune reactions among patients are also a factor that affects the severity of COVID-19 symptoms. The increase in cytokine levels is thought to be a factor that aggravates the symptoms of COVID-19. In this article, we will discuss aspects of the immune response and cytokines that affect the symptoms of COVID-19, as well as some of the immunological treatments currently being studied for COVID-19.
The Role of Electrical Impedance Tomography in Lung Imaging
Authors: Christanto Anthony , Darinafitri Irma
Published: July 2022

Lung imaging in certain conditions, such as in patients with Acute Respiratory Distress Syndrome (ARDS), poses its challenges. Heterogeneity of lung damage in ARDS can only be detected by CT scan, causing treatment delay and increased mortality. Difficulty to perform standard imaging such as CXR in such patients also contributes to the increasing incidence of VALI (Ventilator-Associated Lung Injury) due to diagnosis delay. EIT (Electrical Impedance Tomography) is a novel imaging method that uses electrical impedance modality. EIT is a bedside, continuous imaging method which can depict both solids and fluids (including air) in body cavities, both statically and dynamically. EIT carries the potency to be the primary lung imaging method for patients in intensive care in the future.

Pencitraan paru mempunyai tantangan tersendiri pada beberapa kondisi pasien, misalnya pada sindrom distres pernapasan akut (Acute Respiratory Distress Syndrome/ARDS). Heterogenitas kerusakan paru pada ARDS hanya bisa dideteksi menggunakan CT scan, mengakibatkan keterlambatan penanganan serta meningkatnya mortalitas. Kesulitan melakukan pencitraan standar seperti foto polos toraks juga turut berkontribusi dalam meningkatnya insidens VALI (Ventilator-Associated Lung Injury) karena keterlambatan diagnosis. EIT (Electrical Impedance Tomography) merupakan metode pencitraan baru menggunakan modalitas impedansi listrik. EIT dapat mencitrakan benda padat ataupun fluida (termasuk udara) dalam rongga tubuh dengan baik, baik secara statis maupun dinamis, secara kontinu (bedside). EIT berpotensi menjadi metode utama pencitraan paru pasien-pasien di perawatan intensif.
Infeksi TORCH Maternal dan Kongenital
Authors: Supit Brigita
Published: July 2022

Infeksi perinatal secara kolektif disebut infeksi TORCH untuk toksoplasma, rubella, cytomegalovirus, HSV, dan organisme lainnya seperti HIV, parvovirus B19, enterovirus, EBV, VZV, virus hepatitis B, virus hepatitis C, campak, adenovirus, virus Zika, dan Treponema pallidum. Infeksi dapat asimptomatis atau menyebabkan gejala minor pada ibu; namun merupakan penyebab mortalitas fetal dan neonatal yang signifikan dan merupakan kontributor penting untuk morbiditas pada anak-anak. Diagnosis infeksi perinatal berpusat pada dua hal, yaitu identifikasi infeksi maternal akut (terutama infeksi primer) dan verifikasi keterlibatan fetus atau neonatus.

Perinatal infections are collectively named TORCH infections, for toxoplasma, rubella, cytomegalovirus, HSV, and other organisms such as HIV, parvovirus B19, enteroviruses, EBV, VZV, hepatitis B virus, hepatitis C virus, measles, adenovirus, and Treponema pallidum. Those infections may be silent or cause only minor symptoms in the mother; however, are significant causesof fetal and neonatalmortality and important contributors to childhood morbidity. Diagnosis of perinatal infection centerson two issues, which are identification of acute maternal infection (particularly primary infection) and verification of fetus or newborn involvement.
Microneedling dengan Platelet-rich Plasma (PRP) untuk Skar Akne Atrofi
Authors: Rohmah Restu Nur
Published: July 2022

Skar atrofi merupakan komplikasi umum akne dan sangat memengaruhi kualitas hidup pasien. Microneedling dengan PRP untuk memperbaiki skar akne atrofi tergolong sederhana, aman, dan efektif. Teknik ini menggunakan jarum mikro untuk menusuk kulit secara superfisial dan menghancurkan kolagen rusak di lapisan atas dermis, mengaktivasi kaskade penyembuhan luka secara normal yang menstimulasi pembentukan kolagen baru sehingga memperbaiki tampilan skar. Artikel ini memaparkan microneedling dengan PRP sebagai modalitas terapi untuk skar akne atrofi.

Atrophic scars are common acne complication and affect patients’ quality of life. Microneedling with PRP is considered simple, safe, and effective for atrophic scars. The technique uses microneedles to puncture skin superficially and break damaged collagen in the superficial layer of dermis, resulting in activation of normal wound healing cascade which stimulates new collagen formation, thus improving scar appearance. This article describes microneedling with PRP as a treatment modality for atrophic acne scars.
Diagnosis dan Tatalaksana Intoleransi Makanan
Authors: Sumadi Jap Arvin Leonard , Adipurnama Alok , Diba Susana Farah
Published: July 2022

Intoleransi makanan adalah suatu respon non imun yang diinisiasi oleh makanan atau komponen makanan. Intoleransi makanan diperkirakan memengaruhi 20-25% populasi dunia. Gejala yang paling sering adalah gejala saluran pencernaan. Terapi dengan cara restriksi beberapa makanan tertentu.

Food intolerance is non-immunological response initiated by a food or food component. It is estimated to affect up to 20-25% population. Gastrointestinal symptoms are the most common symptom in food intolerance. Therapy is by restriction of certain foods.
Tinjauan atas Gangguan Tingkah Laku pada Anak
Authors: Marcel Irvin
Published: July 2022

Tingkah laku menantang dan sulit mengendalikan emosi, hilang kesabaran, merusak properti, dan penipuan / pencurian pada anak-anak prasek¬olah sering dianggap sebagai tingkah laku normal sehingga sulit diketahui tingkat prevalensinya. Tingkah laku seperti menantang lebih mungkin dikenali sebagai "masalah" dibandingkan "gangguan" selama 2 tahun pertama kehidupan. Banyak dokter sulit membedakan antara perkembangan emosi normal (misalnya, ketakutan, menangis) dari tekanan emosional berat berkepanjangan.

Behaviors such as defiance, loss of temper, damaging property, and fraud/theft in preschool children are often considered as normal behaviors so their prevalence is difficult to be predicted. Challenging behaviors and difficulty to control emotions are more likely to be recognized as "problems" than "disorders" during the first 2 years of life. Many doctors feel difficult to distinguish normal developmental emotions (eg, fear, crying) from prolonged severe emotional distress.

 
Pemeriksaan Adenosine Deaminase (ADA) sebagai Alternatif Diagnosis TB pada Anak
Authors: Tarigan Lupita Yessica , Iskandar Deddy
Published: July 2022

Pendahuluan. Diagnostik tuberkulosis (TB) pada anak merupakan masalah tersendiri karena manifestasi klinis yang beragam dan tidak tersedianya standar baku penegakan diagnosis. Kasus. Anak perempuan usia 6 tahun, dengan klinis demam, batuk, dan sesak nafas. Pada pemeriksaan fisik didapatkan penurunan suara napas di rongga dada kanan. Hasil pemeriksaan radiologis didukung ultrasonografi tampak gambaran efusi pleura kanan yang sebagian sudah terorganisasi. Hasil uji laboratorium didapatkan leukositosis dan hasil tes IGRA negatif. Analisis cairan pleura menunjukkan peningkatan kadar adenosin deaminase. Pengobatan TB menghasilkan perbaikan klinis dan radiologis bermakna. Simpulan. Pemeriksaan adenosin deaminase dapat dipertimbangkan untuk alternatif diagnosis TB pada anak.

Diagnosis of tuberculosis (TB) in children is still problematic because of various clinical manifestations and the unavailability of diagnostic standard. Case. A 6-year old girl with fever, cough and shortness of breath. On physical examination, there was a decrease breath sounds in the right chest. Radiology examination showed a partially organized right pleural effusion, supported with ultrasound finding. Lab test found leucocytosis and IGRA test was negative. Pleural fluid analysis showed increased adenosine deaminase level. TB treatment resulted in significant clinical and radiological improvement. Conclusion. Adenosine deaminase test can be considered as an alternative for TB diagnosis in children.

 
COLICO DEL LACTANTE
Authors: Lucas Flores Gabriela Jessenia , Cedeño Espinoza Wilmer Bienvenido , Azua Cedeño Miguel Ángel
Published: July 2022

Es un desorden de etiología desconocida, que se centrá en la persistencia del llanto o en el efecto que tiene el cuidador, usualmente en los primeros meses de vida del infante sano, se define como norma de tres o criterios Wessel, llanto mayor de tres horas al día, más de tres días a la semana y más de tres semanas, por lo general tarde-noche. La prevalencia es inconstante, se estima entre un 8 a 40%, no está en relación ni con el tiempo de embarazo, genero, raza y leche natural de la madre o fabricada, se han reportado entidad entre el cólico del bebe y la inconformidad del relato con los padres, además de la percepción del estrés en los padres, la confianza en la gestación, descontento de los parientes, hay una dificultad interrelación entre la dinámica familiar y el cólico, por lo que las familias presentan inconvenientes en su estado afectivo, estructura y funcionamiento familiar.
CRISIS ASMÁTICA
Authors: Reyes Flores Christian Romeo , Martínez Vergara Ana Lucia
Published: July 2022

El asma es una enfermedad crónica y común que afecta a personas de cualquier edad con una prevalencia del 44%, razón por la cual el tratamiento ya sea este farmacológico o no farmacológico consiste en controlar los signos y síntomas de esta patología para mejorar la calidad de vida de los pacientes y evitar recaídas. En Ecuador, en la provincia de Esmeraldas la prevalencia de síntomas de asma durante los últimos 12 meses fue de 9.4%, lo que demuestra una prevalencia baja de esta enfermedad, sin embargo, solo es el resultado de una provincia de nuestro país. El concepto de asma ha evolucionado constantemente durante estos últimos años, siendo la clave del diagnóstico la inflamación que produce. Sin embargo, el factor hereditario determina el fenotipo en la mayor parte de casos en los que se inicia la edad, sobre todo, edad pediátrica, mientras que la inflamación ocurre de manera tardía como consecuencia de la interacción con el medio ambiente.
CRISIS HIPERTENSIVA
Authors: Garcés Ortega Juan Pablo , Sacoto Blondet Mirka Yokasta , Buenaño Rodríguez Christian Eduardo
Published: July 2022

Las crisis hipertensivas han llegado a posicionarse como un motivo de consulta muy común en el campo hospitalario; que en muchos de los casos llegan a constituir una verdadera emergencia médica; pues a una crisis hipertensiva se la define como un aumento agudo de la presión arterial que pudiese llegar a dañar ya sea funcional o estructuralmente órganos diana. Según recomendaciones del Joint National Committee se considerará como una crisis hipertensiva a un cuadro caracterizado por el aumento de una presión arterial sistólica ≥180 mm Hg y una presión arterial diastólica ≥110 mm Hg.
SARS-CoV-2, MANEJO DIAGNÓSTICO- TERAPEÚTICO
Authors: Campoverde Cisneros Manuel Alfredo , Altamirano Cordero Luisa Cecilia , Ulloa Castro Adriana Fernanda , Arcentales Cayamcela Mauro Javier , Torres Criollo Larry Miguel
Published: July 2022

La Organización Mundial de la Salud (OMS) a finales de diciembre de 2019 reporto la presencia de un nuevo tipo de corona virus en Wuhan China. El Síndrome Respiratorio Agudo Severo (SARS-CoV-2), de etiología viral. Este virus de naturaleza  ARN con alto potencial de transmisión de persona a persona que rápidamente se propago por el mundo hasta ser declarado pandemia

El SARS-CoV-2 invade las células del huésped para posteriormente replicarse, este proceso hace que la carga viral se incremente y se refleje en la sintomatología por la activación del sistema inmunitario .

Según múltiples investigaciones demuestran que existen determinados factores de riesgo y además de la influencia de la estructura del genoma SARS-CoV-2 se relaciona directamente con la mortalidad y recuperación del paciente. El uso de nuevas tecnologías, métodos de prevención y desarrollo de vacunas ha permitido obtener resultados eficaces en el diagnóstico, pronostico y tratamiento de los pacientes.
Design and Analysis on Curvic Coupling
Authors: Shaikh Ahtesham , Allurkar Prof Siddharaj , Karamkar Prof Bhushan
Published: July 2022

It has widely observed that bolts turn loose, when subjected to fluctuating loads. This ultimately reduces the force of bolt and leads to fail in the performance. Such failures can cause sudden great damage in safety critical applications. Therefore, it is necessary to design couplings with high positioning accuracy and high indexing stiffness. So, the concept of curvic coupling was come in to existence. The stresses induced in the coupling have been analyzed by analytical method. A three-dimensional finite element model of curvic coupling is developed in finite element software to compare to analytical results. The model consists of coupling assembly. A moment is applied on coupling & simulates the effects. Based on these results, a finite element analysis should be used if a greater level of detail is required for the analysis of curvic coupling.
Potential Development of Students and the Community Integrated by Al Baghdadi Islamic Boarding School Karawang
Authors: Jamalulail Iqbal , Machdum Sari Viciawati
Published: July 2022

Pesantren is a Faith Based Organization (FBO) that is based on religion that has concern for human development. Empowerment in the Islamic boarding school area through the development of community and Santri potential in an integrated manner can improve and create a prosperous society in the economic sector in particular. This research aimed to describe and explain the development of students at the Al Baghdadi Islamic Boarding School in order to increase the potential of the community, the stages and steps of the school in increasing the community's potential, and the outcome of increasing the potential of students and the community. The method used in this study is a qualitative type with a phenomenological approach. This research was carried out at the Al Baghdadi Islamic Boarding School on Proklamasi Street, Sasak Hamlet, Amandari Village, Rengasdengklok District, Karawang Regency, West Java. As for data analysis with open codding, axial codding, and selective coding. The Al Baghdadi Islamic Boarding School carried out the following stages: are constructive and persuasive starting from preparation, social mapping, program planning, implementation, and evaluation where this stage is carried out continuously. Pesantren Al Baghdadi makes improvements to the community both in terms of skills, entrepreneurship, finance, and spirituality. The guidance carried out by the Al Baghdadi Islamic Boarding School for students and the surrounding community has several aspects: significant continuity. This can be seen from the observations that the community and the Pesantren are united. Society has dependence on Pesantren, and vice versa.
ASSESSMENT OF TAX BURDEN IMPACT OF PER INDIVIDUAL TAX TYPES
ON THE ARMENIAN ECONOMY
Authors: MKTRCHYANv Vladimir , SAROYAN Karen , HOVHANNISYAN Martun
Published: July 2022

In the basis of generating the needed state revenues for the efficient operation of each
country is well designed tax policy. Tax system is the basis of the tax policy and it’s study begins and ends with analysis of the main elements, i. e. taxes. Studies on the role and
essence of taxes and their impact on the economy have been conducted since ancient
times and the are still widespread. In addition to providing the needed state revenues,
taxes has also another prior role due to it’s regulatory characteristic as they serve as a
means of implementing income redistribution function the people of different social and
income groups, which aims to balance the disproportion of income and wealth between
these layers. Taking into account the above mentioned, we have made an attempt to
assess the impact of the tax burden for each separate tax types on the economy of the
Republic of Armenia.
EEU ACTIVITY IN CONDITIONS OF CORONAVIRUS
Authors: BAGHDASARYAN Firdus
Published: July 2022

In the current conditions, the coronavirus-caused epidemic has challenged the world
economy and national economies, facing the fact of economic crisis. Creating a deep crisis, it carries risks of disrupting global and regional economies. According to the IMF,
world GDP shrank by 3.1% in 2020, including by 4.5% in developed countries and 2.1%
in developing countries. World trade in goods and services decreased by 8.2%. Although
the global economy is already recovering in 2021, the coronavirus is still considered a
serious threat. It is characterized by high rates of spread, which leads to the unpredictability of any impact. That's why scientists at Singapore University of Technology and Design recommend not making predictions about the epidemic, as traditional forecasting models designed to make accurate predictions now and in the future can lead to misunderstandings in extreme uncertainty. The Corona Crisis or the “Great Quarantine” can serve as a historical test of the “strength” of the economic space of the EEU states.
ORGANISATION, MANAGEMENT, ECONOMIC CONSEQUENCES, AND
LEGAL QUALIFICATION OF THE MASSACRES OF ARMENIANS IN 1988 IN
KIROVABAD (GANDZAK)
Authors: YEGHIAZARYAN Margarita , SHARAFYAN Narek
Published: July 2022

Anti-Armenian pogroms in the city of Kirovabad (Gandzak) of the Azerbaijan SSR in
November-December 1988 were organized. This is proved by the reaction (lack of it) of
the healthcare system to the massacres, the inaction of law enforcement agencies, and
sometimes their active participation in the crimes, disruption of public services in the
Armenian part of the city, and the presence of instigators in the city. Historical data on the
Kirovabad massacres are sufficient to claim that crimes defined by the international
criminal law took place in Kirovabad and other settlements of Azerbaijan in 1988. The
crimes committed against the Armenians in Kirovabad correspond to the elements of the
crime of genocide, as well as the crimes against humanity both with their objective and
subjective aspects.
LABOUR MIGRATION PROCESSES AND THE INSTITUTIONAL BASIS FOR
THEIR REGULATION IN EEU COUNTRIES
Authors: NAZARYAN Grigor , VARDANYAN Tatevik
Published: July 2022

The main characteristics of the modern world economy are the liberali-zation of economic processes, the increasing flows of capital, technology and people. The study of problems and challenges of migration is crucial. Migration issues in Armenia especially in
the framework of EEU have always been relevant. The analysis of the migration situation in EEU countries gives an opportunity to reveal the deep reasons hindering the development of integration union. Labor migration is an economic phenomenon, with the
help of which the state at different stages of socio-economic development can solve the
problems of providing the labor market with means of labor, reduce unemployment, increase investment. Over the years, the migration processes in Armenia, their causes and
consequences, the groups involved and their problems have changed significantly. Armenia's membership in the EEU has a significant impact and importance on these
changes. Migration issues in Armenia, especially within the EEU, are always relevant.
INFORMATION TECHNOLOGIES AND DEVELOPING A SINGLE PAGE
WEB APPLICATION USING THE REACT LIBRARY
Authors: OGHLUKYAN Artur , KARAPETYAN Gevorg
Published: July 2022

At present, the Internet has firmly entered the life of almost every person, has become an integral environment for supporting business processes. Every year technologies develop, and there is a need for web applications that have a fast response to actions in the user interface and work perfectly on all devices (both stationary and mobile). The article discusses the development of the architecture of the client side of a single-page application, its features and implementation using the modern React JavaScript library, and a comparative analysis of the use and performance of libraries for developing the client side of React and AngularJS applications. Also, why would using one of these be more cost effective for a development company than using core-js. Ecommerce has increased trade in services between countries. The sector accounts for 60% of the world's total production. With the advent of modern ICTs, e-commerce facilitates the process of bringing consumers and producers closer together and eliminating geographic distance.
The use of e-commerce will eliminate traditional jobs and replace them with new skills,
requiring workers to be trained in the use of technology so they can compete and win
jobs. This means that e-commerce has a negative impact on manual and unskilled labor, but has a positive impact on technically trained workers who can easily find jobs and help create positions and disciplines that were previously not needed or known.
EFFECTS OF INNOVATION LINKAGES IN THE CONTEXT OF NATIONAL
INNOVATION SYSTEM DEVELOPMENT
Authors: TERZYAN Harutyun , MARGARYAN Andranik
Published: July 2022

The national innovation or innovation system is of central importance for the development of the innovative economy of the country. As a result of the smooth operation of all components of the system, the entry of innovations into the country is carried out more smoothly and efficiently. However, the work of individual components of the national innovation system is not enough to ensure the stability of the system. Numerous research economists have drawn attention to the connections between the individual components of the national innovation system. The effectiveness of the national innovation system depends on the level of their development. In this regard, this study examines the interconnection and mobility of innovative connections and its components in the global and regional context. The article analyzes innovative connections in the con-text of the dynamics of the global innovation index changes in the indicator and comparisons are made at the level of different countries and their groups (clusters). Special attention is paid to Armenia, its neighbors and other EAEU member states. In the abovementioned countries, comparisons of the innovation relations index and the results recorded by its components are carried out. The risks of each of the components of innovation links that create problems for the stable operation of the innovation system are analyzed.
Effect of Text-to-speech Software on Academic Achievement of Students with Dyslexia
Authors: Bhola Neeti
Published: July 2022

Dyslexia is a neurobiological disorder that creates serious difficulties in learning process. Being a special learning disorder, it demands special learning environment with a blend of right approach, method and technology. Text to speech software comes under the head of assistive technology that helps dyslexic children understand and assimilate structure sound and meaning of the words. Present study is an experimental study in which 20 students of 6-12 years of age range were selected and randomly distributed in experimental and control group. Experimental group was taught with text to speech software for four months while control group received no treatment and was taught by conventional method of teaching. In the beginning of the study a pretest was conducted in order to know the prevalent differences among the groups. After four months of intervention post test was conducted. Results revealed that students in experimental group performed significantly better than the control group. Text to speech software contributed to remarkable gains in the achievement of students with dyslexia.
Agricultural cooperation opportunity between Mongolia and Korea
Authors: Dashdavaa Myagmar
Published: July 2022

The agricultural cooperation between Mongolia and South Korea lacks collaboration between the private sectors and is limited to only small-scale projects of governmental and non-governmental organizations at this time. Studying the agricultural cooperation between the two countries shows possible collaboration opportunities with potentially beneficial results for both Mongolia and South Korea. Therefore, for the benefit of the national economy, a collaboration between the private sectors of Mongolia and South Korea should be supported by the government. Assuming that the collaboration between the two countries on the production of highly demanded agricultural products in both the South Korean and the world market is potential, several versions of collaborating opportunities are demonstrated.
Монгол Улс, БНСУ-ын хөдөө аж ахуйн салбарын хамтын ажиллагаа, боломж
Хураангуй: Монгол Улс болон БНСУ-ын хөдөө аж ахуйн /ХАА/ салбарын өнөөгийн хамтын ажиллагаа нь төрийн болон төрийн бус байгууллагуудын хамтран хэрэгжүүлдэг бага хэмжээний төсөл хөтөлбөрүүдээс хэтрэхгүй, хувийн хэвшлүүдийн хамтын ажиллагаа дутмаг байдалтай байна. Хоёр улсын ХАА-н салбарын давуу сул талуудыг харьцуулан судалж үзэхэд харилцан үр ашигтайгаар хамтран ажиллах боломжууд харагдаж байна. Тиймээс улс орны эдийн засагт үр өгөөжөө өгөх Монгол Солонгосын хувийн хэвшлийн хамтын ажиллагааг дэмжих нь зөв. Манай хоёр улс БНСУ болон дэлхийн зах зээлд эрэлт өндөр цөөн хэдэн төрлийн ХАА-н бүтээгдэхүүний үйлдвэрлэлд хамтран ажиллах боломжтой гэж үзсэний үндсэн дээр энэхүү өгүүллийн хүрээнд хамтын ажиллагааны хэд хэдэн хувилбар гаргасан.
Түлхүүр үгс: БНСУ, мал аж ахуй, газар тариалан, экспорт.
ANALYSIS OF ONLINE PLATFORMS AND TOOLS TO GET STARTED WITH DISTANCE AND BLENDED LEARNING
Authors:   English Lecturer Westminster International University In Tashkent Address: 100047,Tashkent, Istiqbol St., 12, Uzbekistan, Askarovna Khodjimatova Albina
Published: July 2022

Nowadays, the demand for distance and blended learning is increasing, and this leads to the problem of choosing the right platform for launching this approach in education. This article aims to analyze the existing platforms and identify the strengths and weaknesses of each system. It also provides an analysis of all existing systems to identify the most convenient among all platforms.
IMPROVEMENT OF STUDENTS' ENLIGHTENING IDEAS THROUGH THE WORKS OF ABDULLAH AVLONI
Authors:   Senior Lecturer Of The Department Of General Pedagogy Jspi, Uzbekistan, Pardaeva Komila
Published: July 2022

In this article, Abdullah Avloni promoted the idea of enlightenment through poetry. Avloni puts freedom and liberty above all else and believes that knowledge is the only way to behave. For this reason, the Motherland encourages the enlightenment of everyone who thinks to bring the slightest benefit to his people. In his work, any methods that could interfere with the mastery of science, including the old method of teaching, were sharply criticized. Science and education, especially European culture, advanced with inspiration.
WEDDING CEREMONIES OF NUROBOD DISTRICT
Authors:   Master Student National University of Uzbekistan, Shodiyorov Umrzoq
Published: July 2022

This article discusses wedding ceremonies in Nurabad district. Each nation has its own set of rituals and customs. The Uzbek people also have their own ethnographic history. The wedding ceremonies of the Uzbek people are especially important in the traditions. In this article, we will explain Uzbek traditions through wedding ceremonies in Nurabad district.
PROBLEMS OF INVOLVING CHILDREN IN INCLUSIVE EDUCATION OBSTACLES ON THE WAY TO KINDERGARTENS
Authors:   Master's Degree Pedagogical Institute Of Termez State University Termez, Uzbekistan, Tavobova Ozoda F.
Published: July 2022

Preschool education is the foundation of an inclusive society, because within its framework, children with disabilities and without disabilities learn, play and grow together. Preschool education increases the chances that the child will receive primary education and then get out of poverty, difficult situations. Since pre-school education is not compulsory, it is much more free than primary education, which gives the opportunity to cooperate with various participants, in particular with the state, non-governmental organizations, the private sector and religious organizations.
GEOGRAPHY CLASSES WITH CHILDREN WITH DISABILITIES
Authors:   Teacher Tashkent Vocational School No. 1 For People With Disabilities Tashkent, Uzbekistan, Madrakhimova Ranokhon
Published: July 2022

This article analyzes the issue of teaching Geography with children with disabilities. During the writing of this article, the authors have developed more interesting, easier, ways to teach geography to children with disabilities, effectively using theoretical and practical approaches.
DEFOLIATION IS AN IMPORTANT MEASURE
Authors:   Doctor of Philosophy in Agricultural Sciences, Head of the department, Fergana Polytechnic Institute, Fergana, Uzbekistan, M.M. Ubaydullaev , S.T. Sultonov ,   Researcher, Fergana Polytechnic Institute, Fergana, Uzbekistan
Published: July 2022

The timing and depth of sowing should be determined by the soil conditions of each region and even each field. The most important is the timely cultivation of the rows.
THE ROLE OF FORMING STUDENTS' CREATIVE RELATIVE THINKING IN PEDAGOGICAL PROFESSIONAL ACTIVITIES
Authors:   Lecturer, Department Of General Pedagogy, Jizzakh State Pedagogical Institute, Uzbekistan, Ropijonovna Sodikova Dilfuza
Published: July 2022

Today, one of the main issues is the education of spiritual, creative, independently thinking, mature people. The main attention is paid to the training of highly qualified personnel who meet high moral and ethical standards, independent thinking, and creativity. This article discusses the role of the teaching profession in the formation of creative thinking among students.
GENDER DIFFERENTIATION OF MASCULINE AND FEMININE VERBALIZATION
Authors:   Eps Teacher, English Language Department Bukara State Medical Institute, Uzbekistan, Obidovna Djalilova Zarnigor
Published: July 2022

The given article aims to identify the fundamental distinctions between male and female verbalization comportment due to gender and cultural identity. This article withal analyzes the state of the art in the study of language changes due to gender. The article analyzes the theoretical and experimental work of Russian and peregrine scientists involved in the study of the gender factor that influences the verbalization comportment of speakers.
STUDY OF THE COMPOSITION AND TECHNOLOGY OF PROCESSING ASH WASTE
Authors:   Senior Lecturer, Almalyk Branch Of The Tashkent State Technical University Named After I. Karimov, Uzbekistan, Abralovna Khoshimkhanova Mukhayyo
Published: July 2022

The article examines the chemical and mineral composition and technological process of processing ash and slag waste for the extraction of rare earth elements from ash and slag waste of the Novo-Angrenskaya TPP. In this regard, the possibility of extracting rare earth elements from acidic solutions on the Purolite C100-H cation exchanger was studied using the example of one of the rare earth elements, lanthanum.
SCIENTIFIC AND THEORETICAL BASES OF PEDAGOGICAL GUIDANCE OF STUDENTS’ INDEPENDENT WORK ON PAINTING
Authors:   Professor Of Fine Arts, Tashkent Region Chirchik State Pedagogical Institute, Uzbekistan, Baymetov Botir B.
Published: July 2022

The importance of self-study in the professional training of future teachers of fine arts, methods for performing practical tasks to acquire theoretical knowledge, practical skills and competencies of a student in the field of drawing, painting and composition, consistent and orderly work of teachers of higher educational institutions are about the process.
VENTURE CAPITAL AS AN ECONOMIC CATEGORY
Authors:   Senior Teacher Of Navoi State Mining And Technological University, Uzbekistan, Rabbonaqulovich Chulliyev Suhrob
Published: July 2022

In this article from the side of the author, the opinions of various scientists concerning the features of venture capital are studied. Venture capital is scientifically and theoretically illuminated as an economic category.
LIGHTWEIGHT RESIDUAL LAYERS BASED CONVOLUTIONAL NEURAL NETWORKS FOR TRAFFIC SIGN RECOGNITION
Authors:   Jizzakh Branch Of The National University, Teacher, Uzbekistan, Mamatkulovich Babakulov Bekzod
Published: July 2022

System for Traffic Sign Recognition and Classification is significantly important for especially traffic safety, traffic surveillance, artificial driver services and by all means, for self-driving cars. Traffic sign recognition plays an important role to tackle the traffic related obstacles. And, as traffic sign recognition is particularly applied to portable devices, lightweight models are essential aspect of the agenda. To overcome the mentioned problems, we propose lightweight convolutional neural networks with residual blocks based deep learning model for traffic recognition systems. We not only present the model efficiency but also show the several conducted experiments will well known deep CNN architectures over publicly available German traffic sign recognition benchmark. Our model showed 99.9 % accuracy by F-score, exceeding other models. At last, our model shows generally validity for traffic sign classification problem.
INTERACTION BETWEEN THE KHIVA KHANATE AND RUSSIA IN THE FIRST HALF OF THE XVIII-XIX CENTURIES
Authors:   Master Degree Student, National University Of Uzbekistan, Shovkinov Jamshid
Published: July 2022

The article analyzes the development of economic, social and diplomatic relations between the Khiva Khanate and Russia.
THE PECULIARITIES OF OFFICIAL-DEPARTMENTAL STYLE
Authors:   2nd Course Master Of Foreign Language And Literature Department,Termez State University, Uzbekistan, Kholmatova G.
Published: July 2022

This thesis deals with the study of the official-departmental style and its peculiarities. It helps to understand the style, structure, composition and lexical features of business correspondence texts.
STUDY OF THE CHEMICAL COMPOSITION OF THE SPRING LEAF AND THE PRODUCTIVITY OF MULBERRY VARIETIES IN THE CONDITIONS OF THE NAVAI REGION STEPPE
Authors:   Candidate Of Agricultural Sciencestashkent State Agrarian University, Department Of Sericulture And Mulberry, Uzbekistan, Rahmonberdiev Vakhobdzhan K. , Sohibova Nigora S. ,   Tashkent State Agrarian Universityassistant Of The Department Of Sericulture And Mulberry Growing, Uzbekistan, Nurov Murodjon M. ,   Master Student Tashkent State Agrarian University, Department Of Sericulture And Mulberry, Uzbekistan, Alikulova Durdona B. ,   Master Student Tashkent State Agrarian University, Department Of Sericulture And Mulberry, Uzbekistan
Published: July 2022

Many researchers have found that, the amount of humidity in the leaves of mulberry not constant and it reduces white getting old of the leaf, in the not weather and salinity soil conditioner mulberry leaves roughens quirkily it can be seen from the table studding leaves of mulberry varieties amount of water is 71,11-76,82% and is tentatively Lite in spring indicators.
THE ROLE OF ENVIRONMENT AND FAMILY IN THE DEVELOPMENT OF CHILD’S PERSONALITY
Authors:   Termez State University Teacher, Uzbekistan, Abdullayevna Sheraliyeva Munavvar
Published: July 2022

The biggest roli and significance ofeducation, heredity as well as environment andfamily in the development of child’s personality are indicated in the article. The biggest roli and significance ofeducation, heredity as well as environment andfamily in the development of child’s personality are indicated in the article.
ORGANIZATION OF TECHNOLOGY OF DRIP IRRIGATION OF COTTON CROP AND THEIR TYPES
Authors:   Master's Degree Student, Tashkent Institute Of Irrigation And Agricultural Mechanization Engineers National Research University Department Of The Use Of Gidromeliorative Systems 2, Uzbekistan, Utkur Ugli Mahmudov Bekzodbek
Published: July 2022

Rational use of Water Resources in the conditions of Global climate change, further improvement of the system of use of Water Resources, increasing the efficiency of irrigation and melioration works, water saving, wide introduction of innovative technologies of saving irrigation is topical. two-thirds of the Earth's sphere is covered with water, 98% of which is depleted salt water. Of the available water resources there are 2,0% fresh water reserves, 79% of which are eternal glaciers, 20% groundwater and 1,0% Lake and river waters. In this article, ideas and opinions are made about the organization of the technology of drip irrigation of cotton crops and their types.
WAYS OF MATERIALS DEVELOPMENT FOR AGRARIAN STUDENTS
Authors:   A Lecturer Of Termez State University, Uzbekistan, Abduqodirovich Allamurodov Yigitali
Published: July 2022

Higher education agriculture teaching methods should be capable of developing students' skills in food production, accessibility, food safety, and nutrition, as well as production economics. Lectures, class debates, class projects, problem solving, and tours and field trips were all typical methods in agriculture schools, according to the findings. Digital learning was barely acknowledged as a teaching strategy in this study, although being recommended in the literature review part. We can talk about approaches to build materials for agrarian students in this essay.
THE ROLE AND IMPORTANCE OF MEDIATION IN THE CONDITIONS OF MODERN MARKET RELATIONS
Authors:   Lecturer Of The Department Of Private Law Sciences Of The Specialized Branch Of The Tashkent State Law University, Uzbekistan, Bakhtakhunovna Djambakieva Feruza
Published: July 2022

This article examines the legal nature and characteristic features of the commission contract in the civil legislation of the Republic of Uzbekistan. Despite the traditional presence of the rules on the commission in the Civil Code, the author believes that the contract of the commission is little studied in the national legal literature and requires further research. As a research task, the author attempts to draw attention to the special position of the domestic legislator in some rules on the commission, which are of a debatable nature. The article notes the positive approach chosen by the legislator on the right of the commission agent to make a transaction for himself, as well as the right to remuneration when making a transaction for himself.
REQUIREMENTS FOR TUTOR SPEECH
Authors:   Fergana State University Doctor Of Philological Sciences, Docent, Uzbekistan, Akmaljanovna Akbarova Zuxro , Ravshan Qizi Topvoldiyeva Fotimahon ,   Fergana State University Master, Uzbekistan
Published: July 2022

This article provides insights into the requirements for tutoring. Information about the importance of the requirements for the educator's speech and its impact on the child's psyche is given with brief and clear ideas.
EXTRACURRICULAR ACTIVITIES IN PROFESSIONAL EDUCATIONAL INSTITUTIONS
Authors:   Teacher Of Special Science Of Vocational School No. 1 Of Sariosiya District Of Surkhandarya Region, Uzbekistan, Kamilova Hanifa Abdurahmonovna
Published: July 2022

This article is devoted to the methods of organizing and conducting extracurricular activities in vocational education in vocational education.
DEVELOPMENT OF TEACHING AND LEARNING FOREIGN LANGUAGES IN UZBEKISTAN
Authors:   Uzbek State Institute Of Arts And Culture, Bobosher Kizi Shovkieva Shohida
Published: July 2022

This article describes the latest developments in the field of language teaching in Uzbekistan, reforms and their implementation, presidential decrees, as well as language teaching and learning institutions established in our country.
DEVELOPING COMMUNICATION SKILLS BY INTRODUCING CHILDREN TO FICTION IN SPEECH DEVELOPMENT CLASSES
Authors:   1st Year Master Of Fergana State University, Uzbekistan, Muhammadolimovna Nosirova Gulira'no
Published: July 2022

The article discusses the development of speech and communication skills by introducing fiction to preschool children.
Analisis Ulangan 19 : 1-13 “Kota-kota Perlindungan”
Authors: Sinaga Janes , Siswanto Daniel , Pelawi Stepanus , Tinenti Max Lucky , Sinambela Juita Lusiana
Published: July 2022

Tujuan penulisan ini adalah untuk menganalisis dan menguraikan mengenai “kota-kota perlindungan” berdasarkan Ulangan 19:1-13.  Teks-teks Perjanjian Lama masih relevan dengan keadaan gereja saat ini. Perlunya melihat dan menemukan makna teologis dari teks-teks tersebut apakah masih berlaku bagi kehidupan saat ini. Pemahaman makna kata dari “kota-kota perlindungan” sebenarnya memiliki kesamaan dengan hukum pidana di Indonesia, khususnya dalam KUHAP mengenai tahanan kota. Perbedaannya terletak pada motivasi dalam melakukan tindakan kriminal dan penggagas dari aturan tersebut. Dalam teks Ulangan 19:1-13, pelaku pembunuhan mendapat perlindungan dalam “kota-kota perlindungan” karena motivasi pembunuhan yang dilakukannya secara tidak sengaja. Jika peraturan mengenai “Rutan” digagas oleh peraturan pemerintah, “kota-kota perlindungan” diprakarsai langsung oleh TUHAN Allah yang menunjukkan bahwa Ia sangat memerhatikan umat-Nya. Penelitian ini menggunakan metode kualitatif dengan mengumpulkan data serta menganalisisnya menjadi data yang komprehensif dari berbagai daftar Pustaka buku-buku, Alkitab dan media online. Melalui penelitian ini diharapkan mamahami makna kota perlindungan dalam penerapan masa kini.
العنف وتأثيره على الاستقرار السياسي في العراق بعد عام 2003 لغاية عام 2013: دراسة في الداخلي و الخارجي
Authors: محمد خميس خلود , خطاب منديل يثرب
Published: July 2022

لقد تعددت المفاهيم والمصطلحات التي تحاول توضيح العنف ولكن يبقى التعريف السائد والمتداول داخل المجتمعات هو الاستخدام غير المشروع للقوة المادية بأساليب متعددة لإلحاق الاذى بالأشخاص والاضرار بالممتلكات وبالتالي خلق العديد من النتائج التي ادت الى خلق حالة عدم الاستقرار السياسي داخل العراق منذ عام 2003 وقد تنوعت ظاهرة العنف في مسبباتها واهدافها فالأسباب الداخلية والعوامل الخارجية تناغمت مع بعضها لأجل ان تسبب العديد من اشكال العنف داخل العراق وبالتالي سيادة عدم الاستقرار ولسنوات عديدة فخروج المحتل من اراضي العراق لم يخفف من حالات العنف بل ان سنوات معينة ازداد فيها في استخدام العنف ضد عموم اطياف الشعب العراقي.