bluuebunny/crossref_metadata_2025 huggingface dataset:
Carrier testing for autosomal recessive disorders: a look at current practice in Germany
Authors: Netzer Christian , Velmans Clara , Erger Florian , Schreml Julia
Published: December 2021

Counseling recurrence risks for monogenic disorders is one of the mainstays of human genetics. However, in practice, consultations concerning autosomal recessive disorders exceed the simple conveyance of a 25 % recurrence risk for future offspring. Medical geneticists should be aware of the multifaceted way in which autosomal recessive disorders can pose a diagnostic and counseling challenge in their daily lives and of the pitfalls they might encounter. Although the intentional or incidental detection of carrier states for autosomal recessive diseases happens more and more frequently, our current practice when clarifying their associated reproductive risks remains unsystematic and often subjectively guided. We question whether the approach of focusing on small recurrence risks for a single familial disease with extensive single-gene tests in the partner of a known carrier truly addresses the counseling needs of a couple seeking preconceptional genetic advice. Different perspectives between patients and medical practitioners (or between different medical practitioners) on “acceptable risks” or the extent to which such risks must be minimized raise the question of whether existing professional guidelines need to be clarified.
Genetic counseling: development of requirements, contents, and quality management in Germany
Authors: Kreuz Friedmar R.
Published: December 2021

To carry out quality management of genetic counseling, it is important to know what genetic counseling exactly means and who the players are. The term “genetic counseling” was first defined by Reed in 1947. It describes a communication process dealing with genetic facts and psychosocial aspects and is an education process, too. It has always been understood in the context of individual and family problems, and is unrelated to eugenics. In 1975 the Ad Hoc Committee of the American Society of Human Genetics published a more detailed description. With the development of new diagnostic techniques and methods in human genetics, the requirements of genetic counseling and its contents changed. Today a genetic counselor has to apply diagnostic, predictive, susceptibility, pharmacogenetic, carrier, prenatal, and preimplantation testing, as well as genetic screening. The German Human Genetic Examination Act (Genetic Diagnosis Act – GenDG) and national and international associations recommend to embed genetic testing into genetic counseling. Based on experiences of the author, some examples of pitfalls in genetic counseling are illustrated, as there are so many individual situations and requests that it seems impossible to carry out quality management. Nevertheless, the Commission for Quality in Genetic Counseling and Clinical Genetics of the Professional Association of German Human Geneticists started a pilot ring trial in 2018 with a given counseling situation. The task was to write the human genetics comment with the help of a checklist containing all issues necessary. The evaluation was conducted with the help of a catalogue of criteria which had been established beforehand and a score adjusted to the individual situation. The first genuine pilot trial was launched in 2020. It represents a possibility for quality management in genetic counseling.
Challenges and opportunities for modeling monogenic and complex disorders of the human retina via induced pluripotent stem cell technology
Authors: Plössl Karolina , Milenkovic Andrea , Weber Bernhard H. F.
Published: December 2021

The human retina is a highly structured and complex neurosensory tissue central to perceiving and processing visual signals. In a healthy individual, the close interplay between the neuronal retina, the adjacent retinal pigment epithelium and the underlying blood supply, the choriocapillaris, is critical for maintaining eyesight over a lifetime. An impairment of this delicate and metabolically highly active system, caused by genetic alteration, environmental impact or both, results in a multitude of pathological phenotypes of the retina. Understanding and treating these disease processes are motivated by a marked medical need in young as well as in older patients. While naturally occurring or gene-manipulated animal models have been used successfully in ophthalmological research for many years, recent advances in induced pluripotent stem cell technology have opened up new avenues to generate patient-derived retinal model systems. Here, we explore to what extent these cellular models can be useful to mirror human pathologies in vitro ultimately allowing to analyze disease mechanisms and testing treatment options in the cell type of interest on an individual patient-specific genetic background.
Cyclopentasiloxane (D5) as a Non-Polar Masking Agent for Water-Sensitive Substrates During Polar Solvent Treatment
Authors: Köhler Karen , Brückle Irene , Henniges Ute
Published: December 2021

D5 (decamethylcyclopentasiloxane), a non-polar solvent that evaporates slowly, was tested for its suitability as a temporary masking agent for water-sensitive media on paper objects undergoing aqueous treatment. Three different treatment-related settings were tested on five different paper types, some prepared with water-soluble inks. In 10-min water immersion treatments, D5 proved largely ineffectual in protecting the water-soluble inks. In conjunction with melt-applications of cyclododecane, the addition of D5 enhanced its barrier function only in one case. To test the ability of D5 to prevent tideline formation, the test samples received applications of water, acetone, and a water-ethanol-mixture, creating an interface with freshly D5-impregnated areas. The papers were evaluated visually (VIS, UVA), some after artificial aging. D5 diminished the formation of visible tidelines in the two internally sized papers with low water absorbency in contact with acetone and the ethanol-water mixture, but did not prevent tidelines in contact with water. It also did not protect water-absorbent paper. The results indicate that D5, which is miscible with ethanol and acetone, may disperse tidelines caused by these solvents, but it proved largely insufficient for protecting media during water immersion.
The thermodynamic theory of action potential propagation: a sound basis for unification of the physics of nerve impulses
Authors: Drukarch Benjamin , Wilhelmus Micha M. M. , Shrivastava Shamit
Published: December 2021

The thermodynamic theory of action potential propagation challenges the conventional understanding of the nerve signal as an exclusively electrical phenomenon. Often misunderstood as to its basic tenets and predictions, the thermodynamic theory is virtually ignored in mainstream neuroscience. Addressing a broad audience of neuroscientists, we here attempt to stimulate interest in the theory. We do this by providing a concise overview of its background, discussion of its intimate connection to Albert Einstein’s treatment of the thermodynamics of interfaces and outlining its potential contribution to the building of a physical brain theory firmly grounded in first principles and the biophysical reality of individual nerve cells. As such, the paper does not attempt to advocate the superiority of the thermodynamic theory over any other approach to model the nerve impulse, but is meant as an open invitation to the neuroscience community to experimentally test the assumptions and predictions of the theory on their validity.
Kinematop
Authors: Jarec Morana , Gulin Zrnić Valentina
Published: December 2021

U ovome se članku povezuju studije prostora, mobilnosti i infrastrukture
kako bi se uspostavila nova prizma u kojoj se prelamaju pitanja i potencijalni odgovori o konstruiranju značenja kretanjem. Rad se temelji
na istraživanju prometnica koje prolaze kroz Gorski kotar (Lujzinska cesta Karlovac – Rijeka i autocesta Zagreb – Rijeka) te njihovoj analizi
u dijakronijskoj perspektivi i kroz etnografsko istraživanje, koje obuhvaća i istraživanje vožnjom prometnicama. Preplićući prometnu infrastrukturu (prometnice i pripadajući objekti), prijevozno sredstvo (automobili) i okoliš (krajolik) kojima prometnica/automobil prolazi te uvodeći mobilnost i otjelovljenost kao temeljna načela oblikovanja prostora kao i odnose koji u takvoj konstelaciji nastaju između ljudi, prometnica i okoliša u kretanju te ljudi međusobno tijekom putovanja, u radu uvodimo pojam kinematop kojim povezujemo prostore mobilnosti i prakse mobilnosti u stvaranju značenjskih mjesta kretanjem.
Apotropejska Muka Isuskarstova
Authors: Vučković Josip
Published: December 2021

Muka Isuskarstova je pučki nabožni tekst koji promiče štovanje Kristove krvi i rana. Nastao je u ranome novome vijeku kao odjek kasnosrednjovjekovnih oblika pobožnosti koji su se temeljili na retorici
nabrajanja i prebrojavanja. Tipična ranonovovjekovna verzija Muke Isuskarstove sastoji se od Kristova obraćanja trima mističarkama koje su
izmolile njegovu obznanu broja primljenih udaraca i prolivenih kapi krvi tijekom muke, od opisa višegodišnje molitvene pobožnosti u čast muke, od popisa milosti koje se tim oblikom pobožnosti mogu steći i od atribucije apotropejskih svojstva vlastitim prijepisima. Muka Isuskarstova je potvrđena u brojnim kulturama (npr. engleskoj, etiopskoj, irskoj, njemačkoj, talijanskoj), ali dosad nije bila zamijećena njezina raširenost na prostoru hrvatskoglagoljske pismenosti.
Ovaj je članak zamišljen kao analiza sačuvanih hrvatskoglagoljskih potvrda Muke Isuskarstove i njima srodnih nabožnih tekstova u kojoj će se posebna pažnja posvetiti širemu komparativnome kontekstu. Usporedba hrvatskoglagoljske Muke Isuskarstove s talijanskim amuletom slična sadržaja koji je pronađen u Roccapelagu (Emilia-Romagna) pokazuje da je pojava Muke Isuskarstove na hrvatskoglagoljskome prostoru rezultat prekojadranskoga kulturalnoga transfera. Osim toga, u radu se pokazuje da hrvatski glagoljaši Muku Isuskarstovu nisu samo prepisivali u kodeksima nego su je doista upotrebljavali pri proizvodnji amuleta.
Development of an In Situ Measurement Device for Airfield Pavement Interface Characterization
Authors: Gharbi Maïssa , Broutin Michaël , Roussel Jean-Marie , Chabot Armelle
Published: December 2021

Regular pavement condition evaluation is the key to ensuring a good asset management of in-service pavements, because it allows anticipating and optimizing maintenance or rehabilitation works. In particular, interface bonding conditions between asphalt concrete layers are of major concern because in most cases, structural problems come from interface defects, and furthermore, they have a huge impact on the pavement current mechanical behavior and its remaining service life. Usual structural nondestructive testing devices do not allow assessing this parameter on their own. This is the reason why there is a need for an in situ measurement system. The French Civil Aviation Technical Center (STAC) launched an ambitious research and development program with the objective of developing a proof-of-concept for such a device and associated data analysis methodology, which enables characterization of the interface response for several mechanical solicitations, including rolling-wheel passage or heavy weight deflectometer dynamic impulse load, with a two-fold purpose: a better understanding for research purposes of the interface’s mechanical behavior and its evolution during the life of the pavement and to have at their disposal an operational tool to evaluate the interface bonding condition of in-service pavements. This paper presents the measurement device developed by the STAC. It is inspired by the ovalization system invented in the 1970s by the Laboratoires des Ponts et Chaussées, which consists of measuring the diameter variation of a core-hole in three horizontal directions (longitudinal, transverse, and 45°) during the passage of a rolling-wheel. The first part of the paper focuses on the device development process that led to the final prototype. The second part is dedicated to the 3-D finite element modeling developed for data analysis. The results from a field survey, performed on the STAC’s test facility, are finally presented and compared with numerical simulations.
Czynniki ryzyka występowania zakażeń miejsca operowanego w ortopedii oraz zasady prowadzenia nadzoru epidemiologicznego nad miejscem operowanym
Authors: Słowik Róża , Kołpa Małgorzata , Wałaszek Marta
Published: December 2021

Zakażenia miejsca operowanego (ZMO) są jednymi z najczęstszych i najpoważniejszych powikłań pooperacyjnych, które mogą prowadzić do wydłużenia czasu hospitalizacji, wzrostu kosztów leczenia, a nawet zgonu pacjenta. Istotnymi składowymi zapobiegania zakażeniom miejsca operowanego są: znajomość czynników ryzyka ZMO, przebiegu operacji i środowiska szpitalnego, a także prowadzenie skutecznego nadzoru w oparciu o wskaźniki epidemiologiczne. Wiedza ta może wpłynąć na zniwelowanie ryzyka rozwoju ZMO do minimum. Działania podejmowane w ramach nadzoru epidemiologicznego nad miejscem operowanym powinny opierać się na spójnych procedurach, umożliwiających optymalne przygotowanie pacjenta do przeprowadzenia operacji oraz zmniejszenie ryzyka ZMO na każdym etapie opieki szpitalnej.
Ocena wrażliwości szczepów wzorcowych bakterii na metenaminę z salicylanem fenylu (lek Urosal®)
Authors: Kowalska-Krochmal Beata , Woroń Jarosław , Dydak Karolina
Published: December 2021

Urosal® należy do dostępnych w Polsce leków wskazanych do stosowania w profilaktyce i leczeniu zakażeń układu moczowego (ZUM). Zawiera on metenaminę o działaniu przeciwdrobnoustrojowym oraz salicylan fenylu o działaniu przeciwbólowym i przeciwzapalnym. Cel pracy W badaniach własnych oceniono wrażliwość na lek Urosal® wybranych wzorcowych szczepów bakterii, z uwzględnieniem szczepów opornych na antybiotyki. Materiał i metody Podczas testów wykorzystano metodę mikrorozcieńczeń w bulionie oraz metodę oceny aktywności in vitro w sztucznym moczu, którego skład przypomina mocz naturalny. Wyniki Uzyskane wyniki badań wskazują na potencjalną zdolność metenaminy z salicylanem fenylu do hamowania zarówno bakterii Gram-dodatnich, jak i Gram-ujemnych, w tym Pseudomonas aeruginosa, będących czynnikiem etiologicznym ZUM. Wnioski Stwierdzona we wstępnych badaniach in vitro aktywność przeciwbakteryjna leku Urosal® stanowi podstawę do dalszych badań uwzględniających szczepy kliniczne pochodzące z zakażeń układu moczowego.
Whole genome and transcriptome analysis of genetic determinants associated with cyclophosphamide in vitro in pediatric acute leukemias
Authors: Szczepanek Joanna , Górka Sylwia , Domagalski Krzysztof , Dejewska Joanna , Pogorzała Monika , Styczyński Jan , Tretyn Andrzej
Published: December 2021

Introduction: The main objective was to implement the determinations of the ex vivo resistance to cyclophosphamide and to identify the genetic profile for pediatric patients with acute leukemias. Methods: In order to determine the ex vivo drug resistance profile, MTT cytotoxicity assay was performed on mononuclear cells. Gene expression profiles were prepared on the basis of cRNA hybridization to oligonucleotide arrays of the human genome (Affymetrix). We performed also array-based comparative genomic hybridization using a SurePrint G3 Human CGH Microarray. Data was analyzed by bioinformatics tools. Verification of the relative expression level of 20 genes was carried out by qRT- PCR. Results: We observed a multitude of differentially expressed genes, e.g. ANXA1 (FC=3,04), BCL2A1 (FC=2,69), SERPINA1 (FC=2,12), DHRS7 (FC=2,13), PCDH9 (FC=- 4,58), TTC28 (FC=-2,25) and DUSP1 (FC=-2,91). The expression of genes that code for inflammation mediated by chemokine and cytokine signaling, Wnt, angiogenesis and integrin signaling and T cell activation pathways genes affect the sensitivity of leukemic blasts to cyclophosphamide. Transcriptome level changes are associated with chromosomal aberrations, especially located on chromosomes 8, 10, 14, 15, 16 and 22. Conclusion: Our work delineated genes with differentiated expression and recurrent copy number changes, and revealed novel amplified loci and frequent deletions in resistant to cyclophosphamide cells, which may guide future work aimed at identifying the relevant target genes. In particular, deletion seems to be a frequent mechanism of IFIT3 gene inactivation. ANXA1, SERPINA1, TCF7 and BCL2A1 may also be included among the candidate genes of resistance (Ontological analysis).
Age and Composition of Zircons From the Devonian Petrivske Kimberlite Pipe of the Azov Domain, the Ukrainian Shield
Authors: SHUMLYANSKYY L.V. , KAMENETSKY V. , BORODYNYA B.V.
Published: December 2021

Results of a study of U-Pb and Hf isotope systematics and trace element concentrations in five zircon crystals separated from the Devonian Petrivske kimberlite are reported in the paper. Four zircons have yielded Paleoproterozoic and Archean ages, while one zircon grain gave a Devonian age of 383.6±4.4 Ma (weighted mean 206Pb/238U age). The Precambrian zircons have been derived from terrigenous rocks of the Mykolaivka Suite that is cut by kimberlite, or directly from the Precambrian rock complexes that constitute continental crust in the East Azov. The Devonian zircon crystal has the U-Pb age that corresponds to the age of kimberlite emplacement. It is 14 m.y. younger than zircon megacrysts found in the Novolaspa kimberlite pipe in the same area. In addition, Petrivske zircon is richer in trace elements than its counterparts from the Novolaspa pipe. Petrivske and Novolaspa zircons crystallized from two different proto-kimberlite melts, whereas the process of kimberlite formation was very complex and possibly included several episodes of formation of proto-kimberlite melts, separated by extended (over 10 M.y.) periods of time.
Distribution of Arsene and Mercury in the Coal Seam k5 of the Kapitalna Mine, Donbas
Authors: ISHKOV V.V. , KOZII Ye.S.
Published: December 2021

The aim of the research is to establish the characteristics of the As and Hg distribution, which belong to the main toxic elements of coal, in the coal seam k5 of the minefield Kapitalna (Krasnoarmiiskyi geological and industrial area of Donbas) and their main genetic factors. The applied methods include sampling coal from mine workings and from core-samples duplicates of wells from 1981 to 2014; identification of the inorganic part of the coal seam, macroscopically diagnosed by standard mineralogical methods as sulfide, silicate and carbonate fractions. According to textural and structural features, they are divided into groups of syngenetic and epigenetic origin; the mineral composition of these two groups was determined by optical microscopy using MIN-8 and MBS-9 microscopes and by X-ray diffraction analysis. Fractional analysis of the density of coal from duplicates of the original samples was carried out to identify the substance of the inorganic part of the coal seam; Arsenic and Hg contents were determined by atomic absorption analysis in the substance of all initial and final samples; normalization of all values of Hg and As concentrations and technological parameters of coal; statistical processing of all geochemical information using Excel 2016 and Statistica 11.0, which included correlation and regression analysis; calculation of the coefficients of affinity of Hg and As with organic matter, the coefficients of the reduced concentration of the investigated elements, the coefficients of the reduced extraction of these elements in the fraction of different densities; construction of maps of normalized isoconcentrates; changes in the regional component of normalized content and gradient of normalized content were performed using the program Surfer 11. We found a genetic link between high concentrations of As and Hg in the coal seam k5 of the minefield Kapitalna with tectonic features, the Central overthrust and associated zones of increased fracturing. The accumulation of As and Hg in the coal seam k5 of the minefield Kapitalna, bound to the organic component of the coal seam, is epigenetic. The practical significance of the work is that their high concentration in the high-density fractions of coal will lead to their gravitational accumulation in the waste.
Deformidad de Gibbus no tuberculosa tratada con implante cubierto con nanopartículas de plata. Presentación de un caso
Authors: Jacob Diego Fabio , Guimbard Perez Joint Halley , Orosco Falcone Luis David Enrique , Carabajal Juan Carlos , Ortiz Pablo Nicolás
Published: December 2021

Se conoce como enfermedad de Gibbus al colapso de la porción anterior de uno o más cuerpos vertebrales que provoca una cifosis segmentaria de ángulo agudo. En general, este tipo de deformidades son producto de infecciones tuberculosas. Uno de los principales problemas que trae apareado esta deformidad es la compresión medular. En el caso presentado, el paciente sufrió esta enfermedad como consecuencia de una infección no tuberculosa, con cifosis angular pososteomielitis, tratado con doble vía de abordaje, utilizando implantes recubiertos con nanopartículas de plata. Los resultados clínico-radiológicos fueron muysatisfactorios. Este caso presenta la conjugación de dos temas poco frecuentes en la medicina actual; por un lado, un tipo de deformidad de la columna que, rara vez, se debe a una infección no tuberculosa y, por otro lado, el implante utilizado, recubierto con nanopartículas de plata que, pese a las controversias, ofrece una nueva posibilidad de tratamiento para pacientes con un riesgo aumentado de infección asociada a implantes, y resulta de interés que sea reconocido por los cirujanos ortopedistas, puesto que existe evidencia suficiente para afirmar su capacidad para reducir la formación de biopelículas.
Medición intraoperatoria con una aplicación para teléfono inteligente que mejorar la precisión de las osteotomías desrotadoras
Authors: Ferreyra Andrés , Olleac Ramiro , Masquijo Julio Javier
Published: December 2021

El desarrollo de teléfonos inteligentes ha creado nuevas oportunidades para incorporar la tecnología médica en la práctica clínica diaria. La medición intraoperatoria exacta de los grados necesarios de corrección es un desafío frecuente para el cirujano cuando realiza osteotomías desrotadoras. Por lo general, se utilizan clavijas divergentes colocadas proximal y distal a la osteotomía que, luego de la desrotación, deben quedar paralelas. Sin embargo, la medición de estos grados, en general, se hace por estimación visual, lo que suele ser poco preciso. El objetivo de este estudio es describir un detalle técnico que combina la aplicación declavijas divergentes con la medición intraoperatoria mediante telefonía móvil para mejorar la precisión de las osteotomías desrotadoras.
Resultados del bloqueo epidural caudal en pacientes laboralmente activos con dolor lumbar
Authors: Besse Micaela , Baigorria José Francisco , Rosado Pardo José Antonio , Baldasarre Ricardo , Ambrosini Leandro , Sarotto Aníbal José
Published: December 2021

Introducción: El dolor lumbar es una de las entidades categorizadas por la Organización Mundial de la Salud como enfermedades prioritarias y una de las principales causas de ausentismo laboral. El bloqueo caudal epidural es una técnica anestésica utilizada para tratar el dolor lumbar de diversos orígenes.
Materiales y Métodos: Se realizó un estudio observacional descriptivo retrospectivo en pacientes sometidos a bloqueo caudal guiado por radioscopia, entre el 1 de enero de 2017 y el 31 de enero de 2019. Se excluyó a los pacientes con bloqueo caudal previo, con antecedente de cirugía de columna lumbar y a quienes abandonaron el seguimiento. Se registraron variables relacionadas con el paciente y los resultados del procedimiento (dolor según la escala analógica visual, intervención quirúrgica posterior, actividad laboral posterior y licencia médica solicitada).
Resultados: Se incluyó a 38 pacientes (media de la edad 43 años [rango 27-62]). La mediana de dolor a los tres meses fue de 3,5 (rango 2-6), con una diferencia de 4,5 (RIC de -2,7 a -7) respecto del puntaje basal. Estas diferencias fueron estadísticamente significativas (p<0,001). El 55,3% retornó al trabajo al primer mes, y el 52,4% de ellos (n = 11) solo requirió una semana de licencia.
Conclusiones: Los valores del dolor a corto plazo luego del procedimiento se modificaron de forma estadísticamente significativa respecto de los valores basales. El promedio de reinserción laboral al mes fue del 55,3% (n = 21) y el 76,2% de ellos (n = 16) lo hizo a las dos semanas.
Impacto de la pandemia de la COVID-19 en el funcionamiento de un servicio público de Ortopedia y Traumatología: nuestro aprendizaje luego de la primera ola
Authors: Ricciardi Guillermo Alejandro , Locaso Fernando , Pérez Martín Alejandro , Soto Arriaga Santiago , Scalambro Santiago , Salinas Ariel Agustín , Riva Mariano , Elorza Alan , Mansilla Diego , Molina Florencia , Urrica Juan , Ricciardi Gustavo , Manterola Sol , Garfinkel Ignacio Gabriel , Carrioli Gabriel Genaro , Ricciardi Daniel Oscar
Published: December 2021

Introducción: El objetivo principal fue comparar la actividad clínico-quirúrgica de nuestro Servicio de Ortopedia y Traumatología antes de la instauración del plan de contingencia frente a la pandemia de la COVID-19 y durante este, un aspecto relevante para establecer antecedentes que permitan guiar nuestro desempeño ante la segunda ola de casos y futuras contingencias semejantes.

Materiales y Métodos: Estudio analítico observacional longitudinal ambispectivo de los pacientes atendidos en el Servicio de Ortopedia y Traumatología de un hospital del sistema público de la Ciudad Autónoma de Buenos Aires, durante el plan de contingencia frente a la pandemia COVID-19. Como variable de resultado primaria se valoró el número total de cirugías realizadas durante el período de estudio.

Resultados: La pandemia se asoció con menos cirugías totales (p = 0,002), de Guardia (p = 0,000) y de Planta (p = 0,002). Las cirugías totales se redujeron un 81,5%. Las cirugías de urgencia representaron el 97%, diferencia significativa con el período fuera de la pandemia (p = 0,080). Además, el promedio de cirugías por día quirúrgico disponible fue significativamente menor (p = 0,000).

Conclusiones: Creemos que la atención de la enfermedad ortopédica y el trauma musculoesquelético, adaptada a las obligaciones indicadas por el plan nacional y regional de contingencia frente a la pandemia, fue notoriamente menor a nuestro desempeño habitual. Si bien respondimos adecuadamente a las urgencias de nuestra especialidad queda pendiente la posibilidad de estratificar y considerar tipos de pacientes con cuadros pasibles de ser tratados, en forma gradual, durante la pandemia.
Dolor en la región posterior del pie
Authors: Trueba Ricardo
Published: December 2021

Paciente de 27 años, jugador de handball profesional que consulta por dolor en la región posterior del pie.
Dr. Fernando Silvio Silberman (1930-2021)
Authors: Varaona Oscar
Published: December 2021

A veces, es fácil resumir la vida de un hombre, en este caso, buscar el conocimiento, que este saber facilite el alivio del dolor de los semejantes, transmitirlo a las generaciones que le siguen y, luego, buscar metas, lograrlas, avanzando siempre en pos de otras más lejanas.
As fronteiras do opaco
Authors: Bortolotto Benhur
Published: December 2021

O tópico central de O prisioneiro, novela de Erico Verissimo, é, segundo o autor, a estupidez humana em muitos aspectos. Sua declaração é categórica, mas vaga. O texto de Verissimo tem como temas principais o racismo e a guerra, com suas violências e violações. Mas se em aspectos valorativos ambos, a guerra e o racismo, mantém vizinhanças com a estupidez, sua unificação demanda menos subjetividade. A passagem daquilo que os aproxima para aquilo que os iguala é a função ética do libelo humanista do autor. Este artigo se dedica à sua contraparte literária, de caráter epistêmico; tento mostrar que a estrutura da novela permite delinear, para além da ilegitimidade das ações políticas em questão, a fragilidade e a insuficiência das próprias crenças com as quais se pretende fundamentá-las.
Injertos de naranja (Citrus sinensis) y mandarina (Citrus reticulata) en fase de producción
Authors: Pérez-Macias Mercedes , Soto Enio , León-Pacheco Rommel Igor , Rodríguez-Yzquierdo Guastavo Adolfo , Villagrán-Munar Edwin Andrés
Published: December 2021

Introducción. En Venezuela, los cítricos son el quinto frutal más importante, con una superficie cosechada de 18 084 ha y rendimiento promedio de 14,2 t ha-1, por debajo de la producción mundial. A pesar de ello, hay poca información sobre la fisiología y agronomía de los injertos de cultivares de cítricos más utilizados en el país, como parte de una estrategia para seleccionar las mejores combinaciones (injerto/portainjerto) y las épocas más limitantes para la producción del cultivo. Objetivo. Evaluar a nivel agronómico y fisiológico cinco cultivares de cítricos durante el período 2013-2015. Materiales y métodos. Se realizó un ensayo en plantas de cítricos sembradas entre el período de enero del 2013 y agosto del 2015 en el Centro Nacional de Investigación Agropecuaria, Maracay, Venezuela, en tres repeticiones bajo un diseño completamente al azar, para evaluar variables asociadas al intercambio gaseoso y fenología del cultivo en cinco cultivares de los cítricos más importantes de Venezuela. Resultados. 1) Los árboles de cítricos mostraron apertura parcial de los estomas para incrementar la transpiración y disminuir el estrés por alta temperatura y sequía, sin provocar disminuciones en la tasa de fotosíntesis. 2) Las plantas con los mayores valores promedio en las variables de intercambio gaseoso en los injertos (Cleopatra y Volk) y en el portainjerto (Dancy durante los períodos más secos y Valencia en los más lluviosos), provocaron que las combinaciones de Cleopatra-Dancy, Cleopatra-Valencia, Volk-Valencia y Volk-Dancy, alcanzaran el mayor rendimiento fotosintético durante todos los períodos de evaluación. 3) La fase fenológica de brotación en las plantas de cítricos fueron las fuentes de sumideros más importantes para las tasas de asimilación neta de fotosíntesis. Conclusiones. El cultivar Cleopatra-Dancy tuvo el comportamiento más estable para las variables asociadas al intercambio gaseoso y Volk-Dancy para producir en épocas más secas.
An annotated checklist of vascular plants in and around two major high-altitude wetlands of Lahaul-Spiti, Himachal Pradesh, India
Authors: Dey Dipti , Bhojak Puja , Sekar K. Chandra , Arya Dhani
Published: December 2021

We document for the first time the diversity of vascular plants of Chandra Tal and Suraj Tal, two high-altitude wetlands (HAWs) spanning the cold desert region of Lahaul-Spiti, showing the occurrence of 188 species and one variety distributed among 97 genera and 29 families. Only one species, Ephedra intermedia Schrenk & C.A. Mey. is a gymnosperm, and the other 187 species are angiosperms. Of the angiosperms, Asteraceae is the dominant family, consisting of 27 species and one variety in 17 genera. Among the species, six are classified as threatened, 17 species are native, and two species (Eritrichium nanum (L.) Gaudin and Ranunculus trivedii Aswal & Mehrotra) are endemic to the Himalayan region. We provide baseline data for future research on the floristic diversity of two major HAWs of Lahaul-Spiti. We also highlight the importance of HAWs for the conservation of species.
gatekeepers’ puzzle
Authors: Allemana Michael
Published: December 2021

When programming jazz festivals, programming committees grapple with a host of issues regarding stylistic variety and diversity and inclusion. Questions such as whether there are sufficient minority and female musicians or a good musical balance consume a great deal of time during programming meetings. This article examines these issues in the context of the Chicago Jazz Festival. The festival’s programming committee, on which this author serves, comprises local jazz industry professionals of diverse backgrounds—musicians, journalists, club owners, and directors of jazz institutions, all of whom volunteer their time in meetings with officials from the city’s Department of Cultural Affairs. It is argued that diversity and inclusion is articulated and interpreted by programmers, musicians and festivalgoers at the nexus of local social histories, spatial conditions and cultural formations in a local/translocal dialectic, serving as a forum for the inclusive expression of diverse local community values.
Diseño y validación del Cuestionario Socio-familiar de los Dominios de Alfabetización Emergentes en estudiantes de enseñanza pre-escolar chilenos
Authors: Manosalba-Torres Consuelo , Arancibia-Gutiérrez Beatriz
Published: December 2021

El presente trabajo tiene por objetivo dar a conocer el diseño y validación del Cuestionario Socio- Familiar de los Dominios de Alfabetización Emergente (CSDAE), que evalúa el contexto socio-familiar alfabetizador de niños/as chilenos/as en edades tempranas. El estudio contó con una muestra de 213 familias de los niveles socio-económicos bajo, bajo-medio y medio. Los resultados muestran una fiabilidad según alfa de Cronbach de ,90 y un coeficiente de omega ,94. La primera versión del cuestionario agrupó los ítems en cinco factores que explicaron un ajuste satisfactorio. El instrumento es un aporte para la investigación relacionada con la evaluación del ambiente socio-familiar alfabetizador.
Caracterización del perfil y remuneración de los pares evaluadores en el área de negocios y management reconocidos por Minciencias, Colombia
Authors: Cruz-Páez Fabio Orlando , Parra-Montenegro Lizeth Valeria , Lechuga-Cardozo Jorge Isaac
Published: December 2021

El artículo tiene como propósito caracterizar el perfil de pares evaluadores en el área de negocios y management reconocidos por el Ministerio de Ciencia, Tecnología e Innovación (Minciencias), Colombia, y su opinión acerca de la remuneración para la publicación de artículos, temáticas de interés y categorías de revistas científicas indezadas. La metodología empleada fue cuantitativa, el diseño no experimental y nivel descriptivo. Se empleó como intrumento un cuestionario de 15 items a una muestra aleatoria de 190 pares evaluadores - investigadores. Se encontró que en su mayoría los investigadores en negocios y management son categoría junior y prefieren enterarse de las convocatorias a través de redes sociales para investigadores; reciben beneficios económicos de parte de sus instituciones para la publicación en revistas indexadas principlamnete de alto impacto como las indexadas a Scopus, las temáticas de preferencia son administración general. Se concluye que el sistema nacional de investigación colombiano tiene grandes desafíos para estimular el desempeño de investigadores dentro de las instituciones de educación superior y que para desarrollar talento humano más calificado que responda al sistema de calidad de las revistas indexadas se deben realizar esfuerzos para la capacitación, retención y desarrollo de los investigadores que fungen a su vez de pares evaluadores en las revistas científicas.
Big Data Analytics in the Agribusiness Supply Chain Management
Authors: Valencia-Cárdenas Marisol , Restrepo-Morales Jorge Anibal , Día-Serna Francisco Javier
Published: December 2021

Importance and impact of the systems related to Agribusiness and Agri-food, are increasing around the world and demand a paramount attention. Collaboration in the inventory management is an integral part of the supply chain management, related to proactive integration among the chain actors facilitating production and supply, in especial in the agroindustrial sector of the Departamento de Antioquia, Colombia. This research establishes the main relationships between latent variables as collaboration, technology, models, optimization and inventory management, based on a literature review and applying a Structural Equation Model to a survey data of a sample of agribusiness companies. The results show that Available Technologies associated with Big Data, generates improvement of Collaboration Strategies, improving also Forecasting and Optimization; besides, Inventory Planning and Collaboration are related to Available Technologies associated with Big Data. A Poisson regression model and a Structural Equation Model estimations detect that the increasing strategies of technologies and Big Data are favorable to apply collaboration in the supply chain management, increasing possibilities to the enterprise competitiveness.
Consequences of micro-system setting on different component of learning disability
Authors: Rani Nigam , Sangwan Sheela
Published: December 2021

Learning disability refers to a neurological disorder. This disability affects childs’ thinking and learning process. It affects childs’ ability to learn and engage in activities, his or her self-esteem and ability to evaluate difficult situation and make choices. This can lead to trouble with learning new skills and information. Families of learning disabled child also suffer a lot. They find it difficult to deal with the situation. Present study was carried out in Haryana state on learning disabled boys. Hisar district from Haryana state was selected purposively. From Hisar district Block I was selected on random basis. Hisar city was also selected purposively for urban sample. From Block I five villages named Kaimari, Mangali, Harikot, Daya and Singran were selected randomly. A sample of 60 boys (30 from urban and 30 from rural) with learning disability was selected for the study. Learning disability among boys of 10-12 years age group was taken dependent variable. Indian Adaptation of Stanford – Binet (1971) was administered for diagnosis of learning disability among boys of 10-12 years of age. It has the following components: Language, Mathematics, and Creativity. Different micro system variables were considered as independent variable. Results discovered that majority of the respondents were found in below average category for language and mathematics components of learning disability. Result further found that most of the boys were found in above average category in creativity component of learning disability.
Effectiveness of social advertisements in promoting adoption of selected health and hygiene practices
Authors: Bhalla Sumita , Sharma Preeti
Published: December 2021

The present study was conducted with the objective to assess the effectiveness of social advertisements in promoting adoption of selected health and hygiene practices. The study was conducted in purposively selected two districts of Punjab, India i.e. Gurdaspur and Ludhiana. Total eight villages from four selected blocks of selected districts were randomly selected. From each of the selected village 20 rural women were selected randomly. So, in total 160 respondents made a sample for data collection. The most frequently telecasted five government sponsored social advertisements during the month of June, 2017 on Swach Bharat Abhiyan (Clean India campaign), use of ORS/Zinc during diarrhoea, pregnancy check-up, immunization and breast feeding were selected after consultation with experts. Data was collected using pre-tested structured interview schedule. The effectiveness of social advertisement was assessed in terms of adoption stages i.e. awareness, interest and adoption of health and hygiene practices. The findings revealed that the advertisement of Swach Bharat Abhiyan (Clean India campaign) helped 91.25 per cent respondents to adopt the practice of keeping the environment clean. Most of the respondents i.e. 83.13 per cent immunized their children below 5 years of age. Majority of the respondents (66.38%) were at adoption stage of exclusive breast feeding of infants for first 6 months. Nearly half of the respondents (48.13%) were at the interest stage of adopting the practice of check-up of pregnant women. Nearly two fifth of respondents (42.50%) were at adoption stage of using ORS/Zinc during diarrhoea. It can be concluded that social advertisement plays a significant role in influencing people to adopt health and hygiene practices. It is suggested that more emphasis should be given to produce good social advertisement on different issues to promote adoption of better and improved health and hygiene practices.
Preserving the fire: Some thoughts on traditional attire of Bagri females
Authors: Mamta  , Saini Harminder Kaur
Published: December 2021

The past few decades witnessed some developments that have left a permanent mark on the life style and costumes. The traditional costumes, jewellery and other accessories as well as a traditional lifestyle have been adversely affected by various factors of the social change process and vanished into the antiquity. It is significant to document this heritage for posterity and conservation of our age-old rich traditions. The purpose of this study was to explore and document the attire of Bagri females of North Western India. Interview questions were mainly focused on specific information related to the upper and lower garments, headdresses and jewellery and body decoration. Findings of the study revealed that most preferred traditional dresses of Bagri females were Aangi, Jamper, Ghaghro, Bugiyo, Sunkukdo, Chundadi and Pila. In the fashion market, there are some contemporary designs of dresses and jewellery available which shows similarity with Bagri attire.
Coping strategies used in domestic violence
Authors: Rathore Shilpa , Jain Sneha
Published: December 2021

Domestic violence is serious problem all around the world. Domestic violence is as old as the society is. It is used to establish power and control over a partner in an intimate relationship through a pattern of coercive behaviour in terms of physical, verbal, sexual, emotional, or economic within our homes. It may be frequent or infrequent, severe or subtle. Present study was carried out in order to find out the of coping strategies used by women in Domestic Violence. The sample was comprised with 240 women in age range of 24-40 years were selected from district Udaipur (Rajasthan). Coping Strategies of domestic violence scale was developed to see the strategies which were selected at the time of violence. Tool was standardized by the investigator through calculated validity and reliability. The data obtained were formulated in the light of objectives set for the present investigation. Percentage was calculated for each part. The research finding also indicates that women were less coping strategies.
Development of diversified hand woven furnishing products with amalgamated assamese woven motifs and assessment of consumer preference
Authors: Gogoi Nabaneeta , Neog Parishmita , Saikia Dibyashree
Published: December 2021

Handlooms are environment-friendly technology as they require no energy in operation except for the machinery that spins the yarn. The handloom sector plays a strategic role in the upliftment of the rural economy of India, with its attractive products shows dexterity and artistic ability of the weavers. Even today, the rural people of India mostly women grossly depend on the handloom which requires minimum capital and less technical skills. The present study is an attempt to develop diversified hand-woven furnishing products that require less time to produce and can have ever-growing market potentials. Different unique and peculiar products were developed by amalgamated woven designs and products were evaluated to assess the consumer acceptability. The study revealed that design innovation has a tremendous effect on consumer choices. Among the developed designs, design no. 3 and 10 got highest (2.96) WMS followed by design no. 6, 11, 12 (2.92) and design no. 1 (2.90), respectively in different developed products. It was found that a healthy handloom industry requires a broad and varied product range, design intervention, and appropriate marketing mechanisms for higher marketability. Hence, the study can help the weavers of Assam towards a new perspective of value-added products for their sustainable livelihood.
Evaluation of economics of a few green wastes used for income generation inAssam
Authors: Bhuyan Bijoylaxmi , Baruah Rumi
Published: December 2021

There are varied kinds of plant-origin resources, many of which are considered wastes as these materials normally do not find proper economic utilization. Awareness on the utilization of the plant wastes in the household sector is the need of the hour for motivation and impact development among the target group. It can have a great impact on improvement of rural economy in a poor state like Assam. For example - with simple suitable technological intervention the areca palm leaf sheath can be utilized for making biosphere friendly disposable plates and bowls which are biodegradable and have a competitive market edge over paper and other non biodegradable plates made of synthetic materials. Many water bodies like canals, ponds, rivers etc. are choked by the explosive growth of aquatic weed called water hyacinth resulting in enormous direct loss. The prospect of making it an economically blessed weed by properly utilising it as business commodity is getting higher. The opportunity should be trapped by the local or indigenous people by developing adequate entrepreneurship with almost zero raw material cost. A study was under taken with the objectives: To assess the economics of areca palm sheath disposable serving plate making and Assessment of economics of use of water hyacinth for handicraft products. It was revealed that by using 231 numbers of palm leaf sheath per day and an 8 hours of working using two manually operated pressing machines and spending rupees 354 as daily additional cost, a person can earn a profit of rupees one lakh nineteen thousand nine hundred six annually, resulting in a benefit cost ratio of 2.23. On the other hand by making certain utility products using one kg of dried water hyacinth stems @ Rs. 40/- one can earn an average of two thousand nine hundred fifty rupees weekly. The benefit cost ratio was found to be 1.65 which may increase further depending on products of finer quality. Availability of areca plantation and water hyacinth in this part of the country can thus be gainfully utilized as raw material for manufacturing eco- friendly useful biodegradable items with a high potential market face value and thus would help to enhance rural economy.
Training needs assessment of rural women regarding health and nutrition practices in Bikaner district of Rajasthan
Authors: Suchitra  , Sareen Neena
Published: December 2021

The present study was conducted in six panchayat samities out of which Bikaner panchayat samiti was selected. Out of thirty one Gram panchayat in Bikaner panchayat samiti four Gram panchayat were selected one village was selected on the basis of random sampling technique. Findings revealed that the result of training needs of rural women regarding health and nutrition practices showed that “Nutrition for children 0 to 6 years”, ‘Nutritional Recipes’, ‘Balanced diet’, Family planning’, ‘Care of pregnant and lactating mother’, ‘Child care’ were perceived by the rural women as the most important training areas for improved nutritional and health status whereas, ‘Low cost recipes’, and ‘Function of food’, ‘Environmental sanitation’, were perceived as the somewhat important training area by the rural women.The variables namely “family income, education, mass media contact, extension contact were positively and significantly correlated with training needs of the rural women about health and nutritional practices at 1 per cent level of probability. Whereas, age, training participation had negative significant relationship with training needs of the rural women about health and nutritional practices.