bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between disease prognosis and serum calcium and corrected calcium levels in COVID-19 patients
Authors: EKİNCİ Iskender , ÖZKAN Hanişe , BÜYÜKKABA Mitat , KİRAC UTKU İrem , ÇINAR Ahmet , GÜVEN Ramazan , AKARSU Murat , KUMBASAR Abdulbaki , UZUN Hafize , TABAK Ömür
Published: August 2021

Objectives: The present study aimed to evaluate whether low serum calcium (Ca) and corrected calcium (cCa) levels could predict disease prognosis and mortality in patients with COVID-19.
Methods: In this study, we retrospectively enrolled 206 eligible patients with COVID-19, diagnosed at Turkey Kanuni Sultan Süleyman Training and Research Hospital between March 12, 2020 and June 15, 2020.
Results: Serum Ca level was 8.8 ± 0.57 mg/dL and the serum cCa level was 8.99 ± 0.53 in all patients. The patients were divided into two groups, such as hypocalcemic and non-hypocalcemic patients. We observed that serum Ca levels of patients who died were significantly lower than that of surviving patients. A significant negative correlation was found between serum cCa level and albumin level. A significant positive correlation was found between serum cCa level and C-reactive protein, lactate dehydrogenase, ferritin, procalcitonin, troponin, CURB-65 score, and quick Sepsis-related Organ Failure Assessment (q-SOFA) score. Univariate logistic regression analysis revealed that age, respiratory rate, saturation, heart rate, lymphocyte, serum calcium, D-dimer, CURB-65 score, and q-SOFA score were independent predictors of high-risk group of mortality.
Conclusions: This study confirms that the severity of COVID-19 is associated with lower concentrations of serum Ca. The cCa levels were associated with certain prognostic factors. Serum Ca and cCa levels could be an early and helpful marker to improve management of patients with COVID-19. We recommend evaluation of calcium in patients on initial presentation and serial monitoring during hospitalization in order to perform timely and appropriate corrective actions.
Nebinarnost spola in športno pravo
Authors:   University of Maribor, Faculty of Law, Rijavec Vesna , Kraljić Suzana ,   University of Maribor, Faculty of Law
Published: August 2021

To ensure 'fair play', athletes are usually divided into different categories (e.g., according to age or weight). The division of athletes by gender is one of the most important divisions. The classical division into male and female disciplines derives from the physiological assumptions regarding competitors. To ensure the rules of 'fair play' in this regard, sex verifications have been performed in the past. These procedures were invasive and degrading for the athletes. Modern approaches to the definition of gender in sports deviate from the binary concept of gender, representing a significant step towards respect for human rights in this important area.
Vloga farmacije v iskanju protimikrobnih učinkovin (Nove protimikrobne učinkovine in kaj lahko od njih pričakujemo)
Authors: Obreza Aleš ,   University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
Published: August 2021

Transition to the so-called postantibiotic era increases the risk of infections caused by pan-resistant bacterial strains. To control them, the use of antimicrobial agents currently in use will not be sufficient. Therefore the development of new molecules is one of the key issues in pharmacy. Up-to-date methods of drug design are required for their identification, supported by appropriate biochemical and pharmacological evaluation. More explicit involvement of the pharmaceutical industry in the previous research will also be necessary.
Effect of Science Training on Competency with Soft Skills and Certification as Moderation variables
Authors: Warna Hindalah , Rosidi Rosidi , Farhan Djuni
Published: August 2021

Human resource training activities at UPT BLK Singosari are non-formal education programs organized by the government to provide soft skills and certification for trainees. The training, and soft skills and certifications should increase the trainee’s competency. Therefore, this study will examine the effect of training on competence moderated by soft skills and certification.  This is a survey research using explanatory research. This research was conducted at UPT BLK Singosari. This study used a sample of 60 respondents. However, there were 10 questionnaires whose filling was incomplete so that the processed samples were 50 questionnaires. Data was collected using a questionnaire and filled in by respondents. From the data obtained, a moderation analysis is done to examine the effect each variable. This research has three findings. First, training has positive and significant effect on competence. Second, soft skills strengthen the effect of training on competence. Third, certification strengthens the effect of training on competence.
The Effect of Self-Financing on Learning Motivation with Mediation of Training Quality
Authors: Setyowati Endang , Sawitri Dyah
Published: August 2021

This study aims to examine the effect of Self-financing on Training quality and the impact on learning motivation of trainees at UPT BLK Singosari-Malang. This research is important because in the researchers knowledge it has never been studied before and can contribute to Singosari BLK UPT to determine appropriate Self-financing and training. The study population was 60 participants who had attended training at UPT BLK Singosari during 2019 using Self-financing. Because the samples are small, this study uses a census sample, where a total of 60 people are sampled. Data collection uses a questionnaire. Data was obtained by distributing a list of questions about the Self-financing variable and Training quality in relation to learning motivation to respondents. The data obtained were analyzed by multiple regression analysis and path analysis. The results showed that Self-financing directly has a significant effect on Training quality variable. Self-financing directly has a significant effect on variable Learning motivation. The Training quality directly has a significant effect on Learning motivation variable. Self-financing indirectly has a significant effect on Learning motivation mediated by Training quality.
Work Commitment as A Mediator of Work Environment Effect on Employee Performance
Authors: Hidayati Elly Wahyu , Supriyanto Achmad Sani , Ekowati Vivin Maharani
Published: August 2021

This study aims to examine the effect of work environment on work commitments, work commitment on employee performance, and work commitment as a mediator of work environment influence on employee performance. The samples are 43 KPPN employees in Malang. Data are collected directly from the respondents through questionnaires and analyzed with path analysis using SPSS software.  The result shows that work environment has a positive and significant influence on work commitment, and work commitment also has a positive and significant effect on employee performance. Therefore, work commitment proves to be a mediating variable.
Analysis of Working Capital Management in Automotive Industry Sector Listed in Indonesia Stock Exchange
Authors: Bondan Prabowo Satriya Candra , Safitri Rini
Published: August 2021

This study aims to determine the analysis of working capital management in automotive industry sector listed on the Indonesia Stock Exchange. The object of the study consisted of 12 companies included in the automotive industry sector which were listed on the Indonesia Stock Exchange from 2014 to 2018. The results showed that the average collection period, inventory collection period, average payment period, and cash conversion cycle showed fluctuating results during the study period . The less time it takes for a company to collect receivables, the more liquid a company is. While the less time needed to convert raw materials into finished goods shows good results because the inventory will not be too long in the warehouse so that it will reduce costs. The average payment period is relative for each company. That's because every company has a debt agreement with a certain period. The less time needed by the company since the raw materials purchased are paid until the trade receivables from the sale are billed, the better for the company because the faster the time needed to turn money into goods and into cash back which will increase company profits.
Effect of Net Profit Margin and Company Size on Risk Disclosure
Authors: Fatmawatie Naning , Natalina Sri Anugerah , Fauza Hasna
Published: August 2021

Net Profit Margin is part of the profitability ratio, which is a ratio to assess the company's ability to seek profit. Company size is a value that shows the size of the company. Both of these factors have a relationship with risk disclosure. This study aims to determine the Net Profit Margin, Company Size, Risk Disclosure, and the effect of Net Profit Margin and Company Size on Risk Disclosure in Property and Real Estate Companies. Registered with the ISSI 2016-2018 period. This study uses a quantitative approach. The data used is secondary data, analyzed using correlation analysis and multiple linear regression. The sample in this study amounted to 84 annual financial reports. The results showed that Net Profit Margin, Company Size, and Risk Disclosure were in the poor, suitable, and adequate categories, respectively. The partial calculation results show that the Net Profit Margin has no effect on Risk Disclosure, but Company Size affects Risk Disclosure. Meanwhile, the simultaneous calculation results show that Net Profit Margin and Company Size have a significant effect on Risk Disclosure with a value of 13.6%, while other factors explain the remaining 86.4% outside of this study, such as the ratio leverage, liquidity ratios, and product or industry diversification.
The Covid -19 Impact on the Capitalization of Indonesian Sharia Capital Market
Authors: Nengsih Ifelda , Rahmi Mega
Published: August 2021

The purpose of this study is to see whether Covid 19 pandemic affects stocks listed on the Jakarta Islamic Index (JII) in Indonesia. This study uses data time series as seen from the combined Islamic stock price index in JII from July 2019 to July 2020. In testing the hypothesis, the independent sample t-test and Mann Whitney test are applied to prove the effects of the Covid 19 pandemic on the Jakarta Islamic Index. The results showed that there is an impact of the Covid 19 pandemic on JII. A significance value of 0.000 evidence this 0.05 on the independent sample t-test and 0.004 0.05 on the Mann Whitney test. This means that during the covid 19 periods, the JII Index was under pressure compared to conditions before covid 19.
Etude exploratoire de l’impact de l'approche processus sur la performance : Cas des entreprises marocaines
Authors: Benammi Abderrazak , Taj Kacem
Published: August 2021

La question de l’évaluation de l’impact de l’approche processus sur la performance constitue un domaine d’investigation non encore bien exploré au Maroc. Du point de vue académique, il s’agit d’approfondir les investigations afin d’enrichir les études antérieures portant sur la problématique de l’approche processus et la performance des organisations. Du point de vue management, il s’agit de satisfaire un besoin des entreprises en apportant des éléments de réponses à la question de contribution de l’approche processus à l’amélioration de la performance. En se basant sur le modèle « Business Process Management Maturity » et « Balanced Score Card », une étude qualitative exploratoire a été menée avec dix-sept professionnels (dont trois experts) opérants dans des secteurs d’activités différents, afin de comprendre la possibilité d’application de la recherche notamment l’existence et les insuffisances des construits sur le terrain. Cette étude exploratoire nous a permis d’examiner les facteurs clés de succès de l’approche processus et leur impact sur la performance de l’entreprise marocaine en proposant à la fin un modèle de recherche reliant l’approche processus et la performance. Cette recherche s’est confrontée, néanmoins, à des limites liées à l’étroitesse de l’échantillon et à l’impossibilité d’accéder aux données. Cette étude ouvre de nouvelles perspectives en termes de recherche comme le test du modèle proposé dans divers secteurs afin d’avoir une validité externe.

The evaluation of the impact of the process approach on performance is an area of investigation that has not yet been well explored in Morocco. From an academic point of view, it is a question of deepening the investigations in order to enrich previous studies on the problems of the process approach and the performance of organizations. From a management point of view, it is about satisfying a business need by providing some answers to the question on how the process approach contributes to improving performance. Based on the “Business Process Management Maturity” and “Balanced Score Card” model, an exploratory qualitative study was carried out with seventeen professionals (including three experts) operating in different business sectors. This is aimed at understanding the possible application of research and, in particular, the existence and the inadequacies of constructions in the field. This exploratory study help to examine the key success factors of the process approach and their impact on Moroccan company performance by proposing at the end a research model a correlation between the process approach and performance. This research, however, faced limitations related to the small size of the sample and the inability to access the data. This study opens up new perspectives in terms of research such as testing the proposed model in various sectors to obtain external validity.
The Role and Impact of the Islamic Religion on the Auchi Kingdom in Nigeria Since 1914
Authors: Yakubu Suleiman
Published: August 2021

Academic discourse on religion and inter-group relations over the years has been trending in Nigeria. This is due to several cases of inter-ethnic and inter-religious conflicts witnessed in multi-cultural and ethnic Nigeria. The paper argues that despite the escalating ethnic and religious crisis the Islamic religion had played significant roles in the lives of the people of the Auchi kingdom since 1914. It also affirms the view that, as far as Islam is concerned, there were transformative roles the religion played in the lives of the people since 1914 till date. A high level of cordial inter-group relations has been achieved between the Auchi Kingdom and neighbouring communities, owing to inter-communal mechanisms of the same religion and similar culture over the years of interaction. The Islamic religion, which preaches peace, has become interwoven with the cultural practices of the people of the Auchi Kingdom This paper relies heavily on primary and secondary sources. Consulted written sources were cross examined.
Evaluating the German Position Towards Asylum Seekers During the 2015 European Refugee Crisis
Authors: Jamal Muhammad Ahsan , Xie Yue
Published: August 2021

The refugee crisis that emerged in 2015 was considered to be one of the worst political and humanitarian disasters and the huge influx of immigrants that arrived in Europe caused collective concerns among the receiving countries. The general attitude towards immigrants in Germany has been positive for years but the Syrian crisis prompted the German policies to become more lenient towards the refugees. Therefore, this paper analyzes Germany’s policy shift towards refugees after 2015 and examines the reasons behind the positive stance towards immigrants from the existing literature. The paper discusses the role of different factors ranging from economic, foreign policy considerations, ideological concerns to humanitarian values. In addition, this paper highlights the gaps in the literature and proposes directions for future research to comprehend German policies on immigrants. The research concludes with the findings that humanitarian values and past experiences have played a crucial role in shaping Germany’s refugee policy during the European refugee crisis.
Mercado Gastronómico en el Centro Histórico de Ayacucho
Authors:   , Gutierrez Rodríguez Denisse Stephane
Published: August 2021

En el Perú, el aporte de la gastronomía peruana trasciende el aspecto económico e incide de manera gravitante en la revalorización de nuestra cultura. El efecto económico del boom de la gastronomía peruana tiene un impacto inmediato en las actividades de ese sector y en otros rubros productivos como el turismo. El Centro Histórico de Ayacucho fuertemente caracterizado por su devenir histórico su gastronomía se ha convertido en un factor de reafirmación de identidad ayacuchana y de revaloración de sus comidas regionales convirtiéndose en un lugar de difusión gastronómica. El proyecto busca recuperar la importancia de la tipología del mercado como espacio público y su integración en un contexto urbano establecido. El nuevo modelo de mercado fusiona el intercambio de productos, con la difusión de la gastronomía regional de Ayacucho para llegar a un sector turístico y a una cohesión social a través de la mezcla de varios conceptos. Es así que se enfoca en ofrecer espacios para una experiencia gastronómica diferente que se complementa con una serie de actividades culturales y educativas que lo enriquecen. Se propone un mercado gastronómico que se integre al entorno inmediato generando espacios de encuentro social que formen parte de la trama urbana de la ciudad, mediante la creación de plazas públicas, donde los usuarios se junten con el fin de disfrutar de la gastronomía y encuentros sociales.
Propuesta tecnológica para la mejora del proceso de expedición de licencias de conducir para una entidad del estado
Authors:   , Hurtado León Madeley Fiorella , Velásquez Paz Raquel
Published: August 2021

La presente propuesta tiene como objetivo principal plantear una solución tecnológica para mejorar el proceso de expedición de licencias del Ministerio de Transportes y Comunicaciones (MTC) el manejo de la información dentro de sus sistemas, ofreciendo, como parte de la solución tecnológica, un portal web por el cual el ciudadano podrá realizar sus trámites, pagar en línea y reservar una cita para la expedición de su licencia de conducir. La primera parte de la propuesta consiste en un análisis del Ministerio de Transportes y Comunicaciones, a fin de conocer sus procesos de organización y objetivos estratégicos. Para ello, se ha utilizado el Framework Zachman para conocer el contexto de la institución y del proceso en estudio, con el objetivo de comprender la problemática y diseñar una solución para esta. La segunda parte está comprendida por el diseño de la arquitectura, con base en el análisis realizado. La propuesta inicia por elaborar el proceso TOBE y el modelo de negocio, con el propósito de conocer el contexto de la organización y la interacción de los actores que intervienen; luego, se plantean los casos de uso del sistema a lo analizado e identificado como parte de la solución. Finalmente, se debe identificar los drivers arquitectónicos y los estilos de diseño de arquitectura y diseñar el modelo 4C, con la finalidad de plantear un diseño de arquitectura que soporte y cubra las necesidades de la organización.
NONLINEAR OPTICAL AND SPECTRAL PROPERTIES OF HYDROQUINONE & FULLERENE SYSTEMS
Authors: ERGÜRHAN Orkun , PARLAK Cemal , ALVER Özgür
Published: August 2021

Nonlinear optical (NLO) materials have highly interesting photo-physical behaviors, which have a wide variety of applications, from optoelectronics to medicine. NLO properties together with infrared (IR) and nuclear magnetic resonance (NMR) analyses on the interaction between hydroquinone (HQ) and pristine and boron or silicon doped C60 fullerene systems have been investigated by density functional theory (DFT). C60@HQ systems in the cis and especially trans forms have NLO applications. The obtained results related to optical properties such as polarizability and first hyperpolarizability may have useful predictive values which can be of interest.
EFFECT OF PRECONDITIONS AND UNSAFE ACTS ON EVACUATION DURATION IN FIRE DISASTER CONDITIONS (STUDY AT THE INPATIENT BUILDING OF GENERAL HOSPITAL R. KOESMA TUBAN
Authors: Prasetya Erwin Era , Ardyanto W Denny , Notobroto Hari Basuki , Suwandi Tjipto
Published: August 2021

ABSTRACTHospital fires have the potential to cause fatalities and huge material losses,  there were 22 hospital fires covered by newspapers in India in 2011-2012 with 102 dead. Buildings are considered safe if all occupants building threatened by fire must be able to exit and assembly point before available safe egress time. This study aimed to analyze the effect of preconditions and unsafe acts (violations of evacuation procedures) on evacuation duration in fire disaster conditions in the inpatient building of general hospital R. Koesma Tuban. This study was an observational study, a quantitative method and cross sectional design, which were carried out in April-July 2019. Analysis of Covariance test results stated preconditions (age, sex, exercise habits, location of inpatient ward, distance traveled) affect the duration of evacuation (p <0.05) while preconditions (interaction between workers and readiness of workers) don’t affect the duration evacuation (p> 0.05). Violation of evacuation procedures has the potential to influence the duration of evacuation (p = 0.054). The conclusions this study are age, gender, exercise habits, location of the inpatient ward, and distance traveled affect the duration of the evacuation. Keywords: Duration of evacuation, preconditions, violations of evacuation procedures, hospital
OVERVIEW OF SANITATION HYGIENE AND BACTERIOLOGICAL QUALITY OF FOOD AND EQUIPMENT ON FOOD MANAGEMENT SITES AT JUANDA AIRPORT, SURABAYA IN 2019
Authors: Chilmi Devi Shintiya , Yudhastuti Ririh , Utomo Bangun Cahyo
Published: August 2021

ABSTRACTSites for managing and providing food for the community contribute to the emergence of major foodborne diseases. The airport gives notes on how important it is to prevent food-borne diseases. This study aimed to review the sanitary hygiene and bacteriological quality of the food and equipment on food management sites in Terminal 1 of Juanda Airport, Surabaya. This was a descriptive study using a cross-sectional study design. The research population was all 53 food management sites in Terminal 1 of Juanda Airport. A large sample of four food management sites were taken based on the number of food management sites offered to be surveyed every month. The research variables were sanitation hygiene and bacteriological quality of the food and equipment on the food management sites. Data collection on sanitation hygiene was done through observation and interview. Data collection on bacteriological quality of food and equipment was performed by taking and checking food samples and equipment from each food management site. The assessment of sanitation hygiene on the four food management sites in Terminal 1 of Juanda Airport received a score of > 700. The results of bacteriological food quality showed that Escherichia coli was found in food samples produced by one food management site. The results of bacteriological equipment quality showed that there was no Escherichia coli on the equipment used by four food management sites, but the total plate count value on the equipment was > 0. All food management sites in Terminal 1 of Juanda Airport met sanitation hygiene requirements but did not meet the bacteriological quality requirements for equipment because the total plate count value exceeded the threshold value. In terms of bacteriological food quality, most of the food management sites met the health requirements. Keywords: sanitation and hygiene, Escherichia coli, total plate count, airports
PEER COUNSELING TRAINING AS A METHOD OF SEXUAL HEALTH PROMOTION IN ADOLESCENTS
Authors: Isni Khoiriyah
Published: August 2021

ABSTRACT One characteristic of adolescents is their tendency to share information, tell stories, and gather with their peers. They may experience the negative effects of these habits when they do not have adequate life skills, especially in terms of sexuality. On the other hand, these activities present an opportunity for health promotion through peer-based approaches or peer counseling. The goal is to know the effects of peer counseling methods as media of information to increase adolescents’ knowledge and attitude regarding sexual problems. The study used a quasi-experimental approach with a nonequivalent control group design. The sample consisted of 17 respondents between 15-24 years old living in Banguntapan, Bantul, Yogyakarta who fulfilled the inclusion and exclusion criteria. Data were collected with the purposive sampling technique. The research instrument used was a questionnaire. The results showed that there was a difference in the average knowledge level (p = 0.021) and attitudes (p = 0.000) of respondents related to sexuality before and after receiving peer counseling training. Methods and media used in delivering health information to adolescents should be diversified in schools, in the community, and in health services to generate interest in accessing and heeding appropriate health information. Keywords: peer counseling, sexuality, adolescents, health promotion
IMPLEMENTATION OF WATER SUPPLY SUPERVISION IN CLASS 1 PORT HEALTH OFFICE IN JUANDA AIRPORT WORKING AREA, SURABAYA
Authors: Nugrahanik Rizky , Utomo Bangun Cahyo
Published: August 2021

ABSTRACTThe provision of clean water in the Class 1 Surabaya Port Health Office is supervised in accordance with the existing regulations to identify sources that could potentially cause pollution and prevent the occurrence of illness caused by unstandardized water quality and unsafe water supply. This study aimed to describe the implementation of clean water supply supervision in the Class 1 Surabaya Port Health Office in the Juanda Airport working area, Surabaya. This was an observational study which analysis was descriptive in nature. The clean water was tested for physical, chemical, and microbiological parameters, and the results showed that the water quality was in accordance with the Regulation of the Indonesian Ministry of Health No. 416 of 1990 about the Terms and Monitoring of Water Quality. However, the result from the simple chemical inspection test of the water showed that it did not fulfil health standards i.e., the residual chlorine score not equal to 0 (zero). It is suggested that more attention and supervision are conducted by water management authorities to ensure the standard residual chlorine level of 0 (zero). Additionally, expired reagents or reagents that have already changed color should not be used as it will affect the parameters tested. Keywords: Quality of clean water, clean water supply facilities, water sampling process
EVALUATING TOBACCO ADVERTISING VIOLATIONS AND IT’S CONTRIBUTION TO LOCAL REVENUE IN MAKASSAR
Authors: Hamdani Musyarrafah , Wahyuni Sri , Sultan Ismi , Maidin M. Alimin , Wadi Ahmad , Hasyim Hadijah , Shabir Achmad Mawardi
Published: August 2021

ABSTRACT Around 50.82% of the age group 15-19 years were smokers in Makassar city, one of which was influenced by tobacco ads exposure (National Institute of Health Research and Development, 2019b). This study aimed to evaluate the violation of tobacco product advertising to Local Regulation of South Sulawesi No. 1 of 2015 on Smoke-Free Area (SFA) in 2019 and its contribution to local revenue of Makassar City in 2018. This was a descriptive study through a quantitative approach with cross sectional design. The observation was conducted on 21 major roads and the document review was performed by processing and analyzing the secondary data of the Regional Revenue Department of Makassar City 2018. Data were analyzed descriptively using IBM SPSS 22. This study found around 51% of 619 tobacco advertising (banner, billboard, name board, poster, pushcart, and video Tron) did not comply with the  Local Regulation of South Sulawesi 1/2015. The violations were located in SFA (2%); near schools and healthcare facilities (14%); cut off the roads (16%); the size >72 m2 (6%); and near government offices (40%). The contribution of tobacco advertising was only IDR 736,643,634,-., which was around 0.02% of the local revenue. The violation of tobacco advertising to the Local Regulation 1/2015 and a very small contribution to local revenue showed that Mayor Regulation on Total Tobacco Advertising, Promotion, and Sponsorship (TAPS) Ban should be carried out immediately to prevent children to be the target tobacco industries in Makassar City.Keywords: tobacco advertising, TAPS contribution, local revenue
Analisis Kolaborasi Apoteker dan Dokter di Puskesmas Surabaya dari Pespektif Dokter
Authors: Gloria Fransisca , Pristianty Liza , Rahem Abdul
Published: August 2021

Pendahuluan: Diabetes melitus adalah penyakit yang kompleks, suatu penyakit kronis yang membutuhkan perawatan medis terus menerus (kontinyu). Untuk meningkatkan hasil klinis pasien dan keberhasilan dalam terapi diperlukan suatu kolaborasi interprofesi. Tujuan: Penelitian ini menganalisis kolaborasi dokter dan apoteker di Puskesmas se-kota Surabaya khususnya dalam menangani terapi pasien  diabetes melitus dari perspektif dokter. Metode: Desain penelitian cross sectional. Penelitian dilakukan dalam waktu 3 bulan di 63 Puskesmas kota Surabaya dengan responden 63 dokter. Instrumen yang digunakan “Kuesioner Kolaborasi Dokter” yang meliputi variabel bebas (karakteristik pertukaran dengan domain kepercayaan, hubungan inisiasi dan peran spesifikasi) dan variabel terikat (praktik kolaborasi). Analisis data menggunakan analisis nonparametric dengan korelasi Rank Spearman Test untuk mengetahui hubungan antara variabel karakteristik pertukaran. Hasil: Hasil analisis data menunjukkan bahwa terdapat hubungan yang signifikan (p = 0,000) antara masing-masing dari ketiga domain dengan praktik kolaborasi (collaborative practice) dokter dan apoteker. Hubungan inisiasi dokter merupakan domain yang memiliki pengaruh yang paling kuat terhadap praktik kolaborasi, diikuti domain peran spesifikasi dan kepercayaan. Kesimpulan: Ketiga domain dalam CWR memengaruhi praktik kolaborasi, namun dibutuhkan informasi lebih lanjut mengenai implementasi kolaborasi antara dokter dan apoteker di Puskesmas dalam penanganan pasien diabetes melitus serta perspektif apoteker mengenai praktik kolaborasi dengan dokter.
The Short Form-6 Dimension (SF-6D) Validity and Reliability in Hemodialysis Patients
Authors: Fatihah Anisa Zulfa , Andayani Tri Murti , Yasin Nanang Munif
Published: August 2021

Background: Quality of life becomes an important parameter that is needed for assessing the clinical outcome of patients undergoing long-term therapy for chronic diseases, such as chronic kidney failure. Short Form-6 Dimension (SF-6D) is one of the generic instruments that can be used to assess health-related quality of life (HRQOL). The psychometric properties SF-6D test in hemodialysis patients in Indonesia has never been conducted. Objective: Aimed to evaluate the reliability and validity of SF-6D questionnaire in Indonesian version in patients with chronic kidney failure. Methods: This is an observational study with a cross-sectional design involving 117 patients who meet the inclusion and exclusion criteria in the hemodialysis unit in Dr. Sardjito Central General Hospital and UGM Academic Hospital Yogyakarta. Results: The SF-6D questionnaire has good internal consistency, as seen in Cronbach's alpha value of 0.771. In this study, the ceiling effect test showed 6.8% (< 15%). The measurement of convergent validity was carried out using Spearman rho to analyze the correlation of the questionnaires and see its correlation with other instruments (KDQOL-SF36). Based on the research, the correlation coefficient value of 0.768 (> 0.75) indicates very good result for a strong correlation. The SF-6D instrument was able to distinguish the quality of life with a significant value (p < 0.05) in age, occupation, and comorbid groups. Conclusion: SF-6D questionnaire is valid and reliable, so it can be used to measure the HRQOL of hemodialysis patients. The mean SF-6D utility score of hemodialysis patients is high (0.7975 ± 0.1488).
Global Surface HCHO Distribution derived from Satellite Observations with Neural Networks Technique
Authors: Guan Jian , Jin Bohan , Ding Yizhe , Wang Wen , Li Guoxiang , Ciren Pubu
Published: August 2021

Formaldehyde (HCHO) is one of the most important carcinogenic air contaminants. However, the lack of global surface concentration of HCHO monitoring is currently hindering research on outdoor HCHO pollution. Traditional methods are either restricted to small areas or data- demanding for a global scale of research. To alleviate this issue, we adopted neural networks to estimate surface HCHO concentration with confidence intervals in 2019, where HCHO vertical column density data from TROPOMI, in-situ data from HAPs (harmful air pollutants) monitoring network and ATom mission are utilized. Our result shows that the global surface HCHO average concentration is 2.30 μg/m3. Furthermore, in terms of regions, the concentration in Amazon Basin, Northern China, South-east Asia, Bay of Bengal, Central and Western Africa are among the highest. The results from our study provides a first dataset of the global surface HCHO concentration. In addition, the derived confidence interval of surface HCHO concentration adds an extra layer for the confidence to our results. As a pioneer work in adopting confidence interval estimation into AI-driven atmospheric pollutant research and the first global HCHO surface distribution dataset, our paper will pave the way for the rigorous study on global ambient HCHO health risk and economic loss, thus providing a basis for pollutant controlling policies worldwide.
Paleogeography of the West Siberian Sedimentary Basin in the Late Bajocian–Bathonian
Authors: Kazanenkov V.A.
Published: August 2021

—The paper presents results of regional paleogeographic reconstructions of the West Siberian sedimentary basin in the Late Bajocian–Bathonian. Regional paleogeographic maps of the Yu4, Yu3 and upper part of the Yu2 reservoir units were constructed and described for the first time ever. The implemented approach provided insights into the evolution of paleolandscapes and highlighted the deposition features of the Upper Tyumen Subformation and Malyshev Formation in the different parts of the West Siberian basin. The compilation of paleogeographic maps was based on the electrofacies analysis performed for individual parts of the Malyshev stratigraphic horizon, with regard to the core description materials, paleontological, sedimentological, geochemical data and other. The paleogeographic control of the reservoir’s formation in the Bathonian regional reservoir is discussed.
The Theory of Naphthidogenesis: A Quantitative Model of the Catagenetic Evolution of Aquatic Organic Matter
Authors: Kontorovich A.E. , Burshtein L.M. , Livshits V.R.
Published: August 2021

—This study discusses the evolution of the composition of dispersed organic matter from the Bazhenov Formation (West Siberian petroleum basin) and the products of its catagenetic transformation on the basis of the balance and kinetic approaches to modeling of the catagenetic transformation of organic matter and its individual components, primarily kerogen. The results show that the variations in the elemental composition of kerogen and the extent of generation of both hydrocarbons and nonhydrocarbons can be quantitatively described using a simplified kinetic model. Preliminary estimates of the model parameters are given for the averaged Bazhenov-type kerogen. It is shown that numerical modeling of the catagenetic transformation of dispersed organic matter confirms the validity of the recognition of the main phase (zone) of oil generation and the main phase (zone) of gas generation.
Technology Focus: Reservoir Simulation (July 2021)
Authors: Burgoyne Mark
Published: August 2021

In reviewing the long list of papers this year, it has become apparent to me that the hot topic in reservoir simulation these days is the application of data analytics or machine learning to numerical simulation and with it quite often the promise of data-driven work flows—code for needing to think about the physics less.

Data-driven work flows have their place, especially when we have a lot of data and the system is very complex. I’m thinking shales especially, but seeing it being applied to more conventional reservoirs gave me a moment of pause.

I can’t help but think that, in terms of the hype cycle as related to the application of machine learning to numerical simulation, we may be approaching the peak of inflated expectations. I say “approaching,” because many companies appear to be dipping their toes in the water, perhaps because they think they should, but few are truly committing to it. Many vocal champions of the approach exist, but most decision-makers just don’t understand it yet.

If we cannot explain how something works simply, then thoughtful leaders will tend not to trust it. Whether it be numerical-simulation findings or self-organizing neural networks, the need will always exist for a deep understanding and clarity of explanation of both the discipline and method used. To decision-makers, it will be an attractive concept, but they will generally ask to validate against more traditional methods.

I look forward to a future when we are through the trough of disillusionment and start climbing the slope of enlightenment to a new level of productivity. I suspect, though, that it will take at least another 5 years, as our current crop of knowledgeable evangelists become decision-makers themselves and can put in place work flows and teams to leverage the approach appropriately for their problems, intelligently leveraging their years of hard-won experience.

I will lay a wager with you, though, that when that time comes, those new ways of working more efficiently will rely just as much if not more upon a deep understanding of reservoir engineering as our current methods.

I hope you enjoy these papers, which include examples of both the new approach as well as tried-and-true approaches.

Recommended additional reading at OnePetro: www.onepetro.org.

SPE 202436 - Fast Modeling of Gas Reservoirs Using Proper Orthogonal Decomposition/Radial Basis Function (POD/RBF) Nonintrusive Reduced-Order Modeling by Jemimah-Sandra Samuel, Imperial College London, et al.

IPTC 21417 - A New Methodology for Calculating Wellbore Shut-In Pressure in Numerical Reservoir Simulations by Babatope Kayode, Saudi Aramco, et al.

SPE 201658 - Mechanistic Model Validation of Decline Curve Analysis for Unconventional Reservoirs by Mikhail Gorditsa, Texas A&M University, et al.
Extended Reach Drilling with Coiled Tubing: A Case Study on the Alaskan North Slope That Proves the Benefits of Drilling a Straight Hole
Authors: Miszewski Antoni , Miszewski Adam , Stevens Richard , Gemignani Matteo
Published: August 2021

A set of five wells were to be drilled with directional coiled tubing drilling (CTD) on the North Slope of Alaska. The particular challenges of these wells were the fact that the desired laterals were targeted to be at least 6,000 ft long, at a shallow depth, almost twice the length of laterals that are regularly drilled at deeper depths. The shallow depth meant that two of the five wells involved a casing exit through three casings, which had never been attempted before. After drilling, the wells were completed with a slotted liner, run on coiled tubing (CT). This required a very smooth and straight wellbore so that the liner could be run as far as the lateral had been drilled. In this paper, we focus on one of the two wells on which triple casing exit was performed. However, the same considerations and results apply to the other wells on which the same technology has been used.

Various methods were considered to increase lateral reach, including running an extended reach tool, using a friction reducer, increasing the CT size, and using a drilling bottomhole assembly (BHA) that could drill a very straight well path. All of these options were modeled with tubing forces software, and their relative effectiveness was evaluated.

The drilling field results easily exceeded the minimum requirements for success. This project demonstrated record-breaking lateral lengths, a record length of liner run on CT in a single run, and a triple casing exit. The data gained from this project can be used to fine-tune the modeling for future work of a similar nature.
The Impact of Early Achievement of Therapeutic Levels of Vancomycin in Critically ill Patients with Confirmed Gram-positive Infection: A Retrospective Cohort Study
Authors: Sulaiman Khalid Al , Alshaya Abdulrahman , Alsaeed Amjad , Alshehri Nadiyah , Vishwakarma Ramesh , Alzahrani Hamdan , Harbi Shmeylan Al
Published: August 2021

Background: Vancomycin is a commonly used antibiotic in critically ill patients for various indications. Critical illness imposes pharmacokinetic-pharmacodynamics challenges which makes optimizing vancomycin in this population cumbersome. Data are scarce on the clinical impact of time to therapeutic trough levels of vancomycin in critically ill patients. The aim of this study to evaluate the timing to achieve therapeutic trough level vancomycin on 30-day mortality in critically ill patients.Method: A retrospective cohort study for all adult critically ill patients aged 18 years or older with confirmed Gram-positive infection and received vancomycin between January 1st, 2017 and December 31st, 2018 at a tertiary teaching hospital. We compared early (<48 hours) versus late (≥ 48 hours) attainment of vancomycin therapeutic trough levels. Primary outcome was the 30-day mortality in critically ill patients. Secondary outcomes were development of resistant organisms, eradicating microorganisms within 4-5 days of vancomycin initiation, vancomycin-induced acute kidney injury (AKI), and ICU length of stay (LOS). Results: Two hundred and nine patients were included. No significant differences between comparative groups in baseline characteristics. Achieving therapeutic levels were associated with better survival at 30 days (OR: 0.48; 95% CI [0.26-0.87]; p<0.01). Additionally, patients who achieved therapeutic levels of vancomycin early were less likely to develop resistant organisms (OR=0.08; 95% CI [0.01-0.59]; p=0.01). The AKI and ICU LOS were not significant between the two groups.Conclusion: Early attainment of vancomycin therapeutic levels was associated with possible survival benefit.
Rhamnocitrin Ameliorates Ovarian Fibrosis Via PPARγ/TGF-β1/Smad Pathway to Repair Ovarian Function in Polycystic Ovary Syndrome Rats Running Title：rhamnocitrin Ameliorates Ovarian Fibrosis in Polycystic Ovary Syndrome Rats
Authors: Zhou Yanyuan , He Chunhua , Dong Zhewen , Lan Huan , Chong Chaojie , Song Jiale
Published: August 2021

Background: Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders in women, characterized by androgen excess, chronic anovulation and ovarian fibrosis. Rhamnocitrin is an herbal bioactive flavonoid that has anti-inflammation and antioxidant effects. We intended to investigate the impacts of Rhamnocitrin on PCOS-induced ovarian fibrosis and its underlying mechanisms.Methods: Dehydroepiandrosterone (DHEA) induced-PCOS rats were treated with Rhamnocitrin. HE staining was performed to detect ovarian histological features. Ovarian fibrosis was evaluated by Sirius Red and Masson staining. Vaginal smear was examined to exhibit estrus cycle stage and vaginal cornification. The serum hormone levels of FSH, LH, E2 and T were measured with ELISA. The related mRNAs and proteins of fibrosis factors and PPARγ/TGF-β1/Smad2 signaling were detected by RT-qPCR and western blot. The weights of rat bodies and ovaries were recorded. PPARγ inhibitor T0070907 and its agonist GW1929 were employed for the mechanistic investigation.Results: The corpus luteum and follicles were increased and irregular estrous cycle was restored after Rhamnocitrin treatment in PCOS rats. Rhamnocitrin inhibited ovarian fibrosis and down-regulated the expressions of fibrotic factors. Rhamnocitrin reduced the increased levels of LH, E2, and T, and elevated the decreased FSH level in PCOS rats. Besides, Rhamnocitrin elevated the down-regulated PPARγ, and suppressed the up-regulated TGF-β1 and p-Smad2 expressions induced by PCOS. These effects of Rhamnocitrin on PCOS rats could be antagonized by T0070907, whereas GW1929 markedly mimics the functions of Rhamnocitrin. Conclusions: Rhamnocitrin ameliorates ovarian fibrosis in PCOS rats through regulation PPARγ/TGF-β1/Smad2pathway, suggesting it can be a potentially effective therapeutic candidate for PCOS treatment.
Identifying Network Biomarkers of Cancer By Sample-Specific Differential Network
Authors: Zhang Yu , Chang Xiao , Xia Jie , Huang Yanhong , Sun Shaoyan , Chen Luonan , Liu Xiaoping
Published: August 2021

Abundant datasets generated from various big science projects on diseases have presented great challenges and opportunities, which are contributed to unfold the complexity of diseases. The discovery of disease- associated molecular networks for each individual plays an important role in personalized therapy and precision treatment of cancer based on the reference networks. However, there are no effective ways to distinguish the consistency of different reference networks. In this study, we developed a statistical method, i.e. a sample-specific differential network (SSDN), to construct and analyze such networks based on gene expression of a single sample against a reference dataset. We proved that the SSDN is structurally consistent even with different reference datasets if the reference dataset can follow certain conditions. The SSDN also can be used to identify patient-specific disease modules or network biomarkers as well as predict the potential driver genes of a tumor sample.
Antioxidants Supplementation In Acute Amitriptyline Abuse for Pain
Authors: S Hameed Kadar Ali , K Wasim Ali Raja , Navabshan IRFAN , Habeeb Mohammad , Y Ismail
Published: August 2021

The fundamental aim of this study is to establish the role of anti-oxidant supplementation in alleviating acute amitriptyline induced oxidative stress. The effect of supplementation was compared on treatment of acute amitriptyline intoxication cases for pain management, with Alpha lipoic acid (ALA) alone or with vitamin C, with that of healthy individuals (Group I), and those receiving only routine standard treatment (RST) as control (Group II). Total of 132 human subjects divided into 5 groups were supplemented with either placebo, RST, RST with Vitamin C, RST with ALA, or RST with Vitamin C and ALA. Results of this study revealed that the decrease in the level of oxidative stress and enzyme activity was observed among those supplemented with either Alpha lipoic acid alone or along with vitamin C, with a slightly more decrease in the latter group. P value < 0.001 was considered statistically significant. The percentage of benefit of treatment on supplementation with vitamin C and Alpha lipoic acid showed a marked increase in-group V cases after supplementation with both in combination. The results provided that the oxidative stress induced by acute amitriptyline poisoning is comparatively decreased by supplementation with antioxidants like Alpha lipoic acid and Vitamin C, than those only on routine standard treatment.