bluuebunny/crossref_metadata_2025 huggingface dataset:
S.O.V.O.R.A.: A Distributed Wireless Operating System
Authors: Ceballos Henry Zárate , Triviño Jorge Eduardo Ortiz
Published: December 2020

Due to the growth of users and linked devices in networks, there is an emerging need for dynamic solutions to control and manage computing and network resources. This document proposes a Distributed Wireless Operative System on a Mobile Ad-hoc Network (MANET) to manage and control computing resources in relation to several virtual resources linked in a wireless network. This prototype has two elements: a local agent that works on each physical node to manage the computing resources (e.g., virtual resources and distributed applications) and an orchestrator agent that monitors, manages, and deploys policies on each physical node. These elements arrange the local and global computing resources to provide a quality service to the users of the Ad-hoc cluster. The proposed S.O.V.O.R.A. model (Operating Virtualized System oriented to Ad-hoc networks) defines primitives, commands, virtual structures, and modules to operate as a distributed wireless operating system.
Evolutionary Game for Confidentiality in IoT-Enabled Smart Grids
Authors: Boudko Svetlana , Aursand Peder , Abie Habtamu
Published: December 2020

We applied evolutionary game theory to extend a resource constrained security game model for confidentiality attacks and defenses in an Advanced Metering Infrastructure (AMI), which is a component of IoT-enabled Smart Grids. The AMI is modeled as a tree structure where each node aggregates the information of its children before encrypting it and passing it on to its parent. As a part of the model, we developed a discretization scheme for solving the replicator equations. The aim of this work was to explore the space of possible behaviors of attackers and to develop a framework where the AMI nodes adaptively select the most profitable strategies. Using this model, we simulated the evolution of a population of attackers and defenders on various cases resembling the real life implementation of AMI. We discuss in depth how to enhance security in AMI using evolutionary game theory either by a priori analysis or as a tool to run dynamic and adaptive infrastructure defense.
Effect of Nitrogen on Phosphine-Susceptible and -Resistant Populations of Stored Product Insects
Authors: Sakka Maria K. , Gatzali Fotini , Karathanos Vaios T. , Athanassiou Christos G.
Published: December 2020

In this study, we evaluated nitrogen treatment on phosphine-resistant field and -susceptible laboratory populations of different stored product beetles. Nine trials were conducted in commercial nitrogen chambers with the O2 level set at 1.0%. Two different temperatures—i.e., 28 and 40 °C—and three exposure intervals—i.e., 2.5, 3 and 9 d—were used in our tests. Adults of the sawtoothed grain beetle, Oryzaephilus surinamensis (L.) (Coleoptera: Silvanidae); the red flour beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae); and the rice weevil, Sitophilus oryzae (L.) (Coleoptera: Curculionidae) were used in the trials. The insects were placed in vials with different commodities per species and population, and their mortality was measured after the termination of each trial. Then, the vials were kept in incubator chambers at 25 °C and 65% relative humidity for 65 d to measure progeny production. Complete parental mortality was observed in all cases for O. surinamensis and S. oryzae, but there was some survival for T. castaneum at 28 °C and 3 d of exposure. In general, progeny production was completely (100%) suppressed, with some exceptions for all species and populations. The results indicate that low oxygen is effective for all species tested, regardless of their resistance status to phosphine, and can be further adopted as an alternative method to mitigate resistance in stored product beetles.
Shear-Thickening Composites for On-Demand Rebound Performance and Softness
Authors: Tan Yi Jie , Phyo Aung Khant , Chen Lu Heng , Huang Wei Min
Published: December 2020

For footwear insoles, high rebound performance is required in some instances such as for running, while softness for comfort is of higher importance during normal walking and standing to minimize high stress. Hence, materials with rebound performance in some scenarios and softness for other scenarios are desired. In this paper, we investigate rebound performance and hardness of composites made of a shear-thickening material and elastic foam. First, a hydrogel type of shear-thickening material (Slime) is characterized to investigate the influence of water content. After that, two particular shear-thickening hydrogels with better rebound performance (but not outstanding in the shear-thickening effect) are selected and integrated into the elastic foam to produce a composite insole. It is found that, as compared with the commercial elastic insole and commercial shear-thickening insole, softer and superior rebound performance can be achieved simultaneously only if the right shear-thickening material is used in the composite.
Potential Use of Wearable Sensors to Assess Cumulative Kidney Trauma in Endurance Off-Road Running
Authors: Rojas-Valverde Daniel , Timón Rafael , Sánchez-Ureña Braulio , Pino-Ortega José , Martínez-Guardado Ismael , Olcina Guillermo
Published: December 2020

(1) Background: This study aimed to explore wearable sensors′ potential use to assess cumulative mechanical kidney trauma during endurance off-road running. (2) Methods: 18 participants (38.78 ± 10.38 years, 73.24 ± 12.6 kg, 172.17 ± 9.48 cm) ran 36 k off-road race wearing a Magnetic, Angular Rate and Gravity (MARG) sensor attached to their lower back. Impacts in g forces were recorded throughout the race using the MARG sensor. Two blood samples were collected immediately pre- and post-race: serum creatinine (sCr) and albumin (sALB). (3) Results: Sixteen impact variables were grouped using principal component analysis in four different principal components (PC) that explained 90% of the total variance. The 4th PC predicted 24% of the percentage of change (∆%) of sCr and the 3rd PC predicted the ∆% of sALB by 23%. There were pre- and post-race large changes in sCr and sALB (p ≤ 0.01) and 33% of participants met acute kidney injury diagnosis criteria. (4) Conclusions: The data related to impacts could better explain the cumulative mechanical kidney trauma during mountain running, opening a new range of possibilities using technology to better understand how the number and magnitude of the g-forces involved in off-road running could potentially affect kidney function.
A Deep Neural Network for Accurate and Robust Prediction of the Glass Transition Temperature of Polyhydroxyalkanoate Homo- and Copolymers
Authors: Jiang Zhuoying , Hu Jiajie , Marrone Babetta L. , Pilania Ghanshyam , Yu Xiong (Bill)
Published: December 2020

The purpose of this study was to develop a data-driven machine learning model to predict the performance properties of polyhydroxyalkanoates (PHAs), a group of biosourced polyesters featuring excellent performance, to guide future design and synthesis experiments. A deep neural network (DNN) machine learning model was built for predicting the glass transition temperature, Tg, of PHA homo- and copolymers. Molecular fingerprints were used to capture the structural and atomic information of PHA monomers. The other input variables included the molecular weight, the polydispersity index, and the percentage of each monomer in the homo- and copolymers. The results indicate that the DNN model achieves high accuracy in estimation of the glass transition temperature of PHAs. In addition, the symmetry of the DNN model is ensured by incorporating symmetry data in the training process. The DNN model achieved better performance than the support vector machine (SVD), a nonlinear ML model and least absolute shrinkage and selection operator (LASSO), a sparse linear regression model. The relative importance of factors affecting the DNN model prediction were analyzed. Sensitivity of the DNN model, including strategies to deal with missing data, were also investigated. Compared with commonly used machine learning models incorporating quantitative structure–property (QSPR) relationships, it does not require an explicit descriptor selection step but shows a comparable performance. The machine learning model framework can be readily extended to predict other properties.
Surface Nanostructuring of a CuAlBe Shape Memory Alloy Produces a 10.3 ± 0.6 GPa Nanohardness Martensite Microstructure
Authors: Figueroa Carlos Gabriel , Jacobo Víctor Hugo , Cortés-Pérez Jacinto , Schouwenaars Rafael
Published: December 2020

Severe plastic deformation (SPD) has led to the discovery of ever stronger materials, either by bulk modification or by surface deformation under sliding contact. These processes increase the strength of an alloy through the transformation of the deformation substructure into submicrometric grains or twins. Here, surface SPD was induced by plastic deformation under frictional contact with a spherical tool in a hot rolled CuAlBe-shape memory alloy. This created a microstructure consisting of a few course martensite variants and ultrafine intersecting bands of secondary martensite and/or austenite, increasing the nanohardness of hot-rolled material from 2.6 to 10.3 GPa. In as-cast material the increase was from 2.4 to 5 GPa. The friction coefficient and surface damage were significantly higher in the hot rolled condition. Metallographic evidence showed that hot rolling was not followed by recrystallisation. This means that a remaining dislocation substructure can lock the martensite and impedes back-transformation to austenite. In the as-cast material, a very fine but softer austenite microstructure was found. The observed difference in properties provides an opportunity to fine-tune the process either for optimal wear resistance or for maximum surface hardness. The modified hot-rolled material possesses the highest hardness obtained to date in nanostructured non-ferrous alloys.
The Effect of Baking Heat Treatment on the Fatigue Strength and Life of Shot Peened 4340M Landing Gear Steel
Authors: Ahn Seok-Hwan , Heo Jongman , Kim Jungsik , Hwang Hyeongseob , Cho In-Sik
Published: December 2020

In this study, the effect of baking heat treatment on fatigue strength and fatigue life was evaluated by performing baking heat treatment after shot peening treatment on 4340M steel for landing gear. An ultrasonic fatigue test was performed to obtain the S–N curve, and the fatigue strength and fatigue life were compared. The micro hardness of shot peening showed a maximum at a hardened depth of about 50 μm and was almost uniform when it arrived at the hardened depth of about 400 μm. The overall average tensile strength after the baking heat treatment was lowered by about 80–111 MPa, but the yield strength was improved by about 206–262 MPa. The five cases of specimens showed similar fatigue strength and fatigue life in high cycle fatigue (HCF) regime. However, the fatigue limit of the baking heat treated specimens showed an increasing tendency rather than that of shot peening specimens when the fatigue life was extended to the very high cycle fatigue (VHCF) regime. The effect of baking heat treatment was identified from improved fatigue limit when baking heat was used to treat the specimen treated by shot peening containing inclusions. The optimum temperature range for the better baking heat treatment effect could be constrained not to exceed maximum 246 °C.
Discrete Element Modelling of the Mechanical Behavior of Sand–Rubber Mixtures under True Triaxial Tests
Authors: Liu Yiming , Liao Xinchao , Li Lihua , Mao Haijun
Published: December 2020

Sand–rubber mixtures (SRMs) consisting of stiff sand particles and soft rubber particles are typical binary mixture materials that possess a variety of complicated properties. The complexity of the properties of sand–rubber mixtures is increased when complex stress path is involved. This study investigates the mechanical behavior of sand–rubber mixtures under generalized loading conditions using the discrete element method. A series of numerical true triaxial shear tests were conducted on pure sand and sand–rubber mixtures. The effect of rubber content and loading path on both of the macroscopic and microscopic performances of sand–rubber mixtures was investigated, and the associated microscale mechanism was also discussed. Numerical simulations show that the relationship between the peak friction angle ϕp and the intermediate principal stress ratio b is influenced by the addition of rubber particles, and a suggested explanation of this phenomenon is that the rubber particles mainly affect the inherent stability of the strong network. Particle-scale observations, including the coordinate number, the proportion of strong contacts, and the fabric anisotropy, are also presented in this study. Microscopic results confirm the explanation above, and explore the force transmission characteristics of sand–rubber mixtures under generalized loading conditions. This research can provide a reference for the constitutive model development of sand–rubber mixtures.
Comparison of Mechanical Properties of Hemp-Fibre Biocomposites Fabricated with Biobased and Regular Epoxy Resins
Authors: Colomer-Romero Vicente , Rogiest Dante , García-Manrique Juan Antonio , Crespo Jose Enrique
Published: December 2020

Bio- and green composites are mainly used in non-structural automotive elements like interior panels and vehicle underpanels. Currently, the use of biocomposites as a worthy alternative to glass fibre-reinforced plastics (GFRPs) in structural applications still needs to be fully evaluated. In the current study, the development of a suited biocomposites started with a thorough review of the available raw materials, including both reinforcement fibres and matrix materials. Based on its specific properties, hemp appeared to be a very suitable fibre. A similar analysis was conducted for the commercially available biobased matrix materials. Greenpoxy 55 (with a biocontent of 55%) and Super Sap 100 (with a biocontent of 37%) were selected and compared with a standard epoxy resin. Tensile and three-point bending tests were conducted to characterise the hemp-based biocomposite.
Uniform Approximation to the Solution of a Singularly Perturbed Boundary Value Problem with an Initial Jump
Authors: Zhumanazarova Assiya , Cho Young Im
Published: December 2020

In this study, a third-order linear integro-differential equation with a small parameter at two higher derivatives was considered. An asymptotic expansion of the solution to the boundary value problem for the considered equation is constructed by considering the phenomenon of an initial jump of the second degree zeroth order on the left end of a given segment. The asymptotics of the solution has been sought in the form of a sum of the regular part and the part of the boundary layer. The terms of the regular part are defined as solutions of integro-differential boundary value problems, in which the equations and boundary conditions contain additional terms, called the initial jumps of the integral terms and solutions. Boundary layer terms are defined as solutions of third-order differential equations with initial conditions. A theorem on the existence, uniqueness, and asymptotic representation of a solution is presented along with an asymptotic estimate of the remainder term of the asymptotics. The purpose of this study is to construct a uniform asymptotic approximation to the solution to the original boundary value problem over the entire considered segment.
Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells
Authors: Müller Werner E. G. , Neufurth Meik , Wang Shunfeng , Tan Rongwei , Schröder Heinz C. , Wang Xiaohong
Published: December 2020

The mucus layer of the nasopharynx and bronchial epithelium has a barrier function against inhaled pathogens such as the coronavirus SARS-CoV-2. We recently found that inorganic polyphosphate (polyP), a physiological, metabolic energy (ATP)-providing polymer released from blood platelets, blocks the binding of the receptor binding domain (RBD) to the cellular ACE2 receptor in vitro. PolyP is a marine natural product and is abundantly present in marine bacteria. Now, we have approached the in vivo situation by studying the effect of polyP on the human alveolar basal epithelial A549 cells in a mucus-like mucin environment. These cells express mucins as well as the ectoenzymes alkaline phosphatase (ALP) and adenylate kinase (ADK), which are involved in the extracellular production of ATP from polyP. Mucin, integrated into a collagen-based hydrogel, stimulated cell growth and attachment. The addition of polyP to the hydrogel significantly increased cell attachment and also the expression of the membrane-tethered mucin MUC1 and the secreted mucin MUC5AC. The increased synthesis of MUC1 was also confirmed by immunostaining. This morphogenetic effect of polyP was associated with a rise in extracellular ATP level. We conclude that the nontoxic and non-immunogenic polymer polyP could possibly also exert a protective effect against SARS-CoV-2-cell attachment; first, by stimulating the innate antiviral response by strengthening the mucin barrier with its antimicrobial proteins, and second, by inhibiting virus attachment to the cells, as deduced from the reduction in the strength of binding between the viral RBD and the cellular ACE2 receptor.
Microalgae Encapsulation Systems for Food, Pharmaceutical and Cosmetics Applications
Authors: Vieira Marta V. , Pastrana Lorenzo M. , Fuciños Pablo
Published: December 2020

Microalgae are microorganisms with a singular biochemical composition, including several biologically active compounds with proven pharmacological activities, such as anticancer, antioxidant and anti-inflammatory activities, among others. These properties make microalgae an interesting natural resource to be used as a functional ingredient, as well as in the prevention and treatment of diseases, or cosmetic formulations. Nevertheless, natural bioactives often possess inherent chemical instability and/or poor solubility, which are usually associated with low bioavailability. As such, their industrial potential as a health-promoting substance might be severely compromised. In this context, encapsulation systems are considered as a promising and emerging strategy to overcome these shortcomings due to the presence of a surrounding protective layer. Diverse systems have already been reported in the literature for natural bioactives, where some of them have been successfully applied to microalgae compounds. Therefore, this review focuses on exploring encapsulation systems for microalgae biomass, their extracts, or purified bioactives for food, pharmaceutical, and cosmetic purposes. Moreover, this work also covers the most common encapsulation techniques and types of coating materials used, along with the main findings regarding the beneficial effects of these systems.
Left Ventricular Non-Compaction: Review of the Current Diagnostic Challenges and Consequences in Athletes
Authors: Femia Giuseppe , Semsarian Christopher , Ross Samantha B. , Celermajer David , Puranik Rajesh
Published: December 2020

Left ventricular non-compaction (LVNC) is a complex clinical condition with no diagnostic gold standard. At present, there is trepidation about the accuracy of the diagnosis, the correlation to clinical outcomes and the long-term medical management. This article reviews the current imaging criteria, the limitations of echocardiography and cardiac magnetic resonance and the consequences of LV hypertrabeculation in athletes.
Erratum: Melnikov, S.; et al. Water Splitting and Transport of Ions in Electromembrane System with Bilayer Ion-Exchange Membrane. Membranes 2020, 10, 346
Authors: Melnikov Stanislav , Bondarev Denis , Nosova Elena , Melnikova Ekaterina , Zabolotskiy Victor
Published: December 2020

Due to an error during production, Equations (10), (13)–(20), (23), (24) were unreadable in the published paper [...]
The Influence of the Highly Concentrated Energy Treatments on the Structure and Properties of Medium Carbon Steel
Authors: Grigoriev Sergey , Ivannikov Alexandr , Prozhega Maxim , Zakharov Igor , Kuznetsova Olga , Levin Alexandr.
Published: December 2020

This paper describes the effects of combination of electromechanical and ultrasonic treatment on the wear and corrosion behavior of carbon steel AISI 1045. It is shown that the wear resistance of carbon steel AISI 1045 can be improved considerably by hardening the surface. Furthermore, the experimental work indicates that the corrosion rate of the surface decreased because of the combination of the treatments.
Effects of Post Heat Treatment on the Mechanical Properties of Cold-Rolled Ti/Cu Clad Sheet
Authors: Youn Chang-Suk , Lee Dong-Geun
Published: December 2020

Titanium and titanium alloys have excellent corrosion and heat resistance, but weak electric and thermal conductivity. The weak conductivity of titanium can be overcome by cladding with copper, which has high conductivity. Although titanium is expensive, it is selected as a material suitable for applications requiring corrosion resistance such as in heat exchangers. This study was to investigate the effect of post heat treatment on the mechanical properties of the Ti/Cu cold-rolled clad plate by using the interfacial diffusion bonding. A titanium clad by cold rolling should be heat-treated after the rolling process to improve the bonding properties through the diffusion of metals and removal of residual stress due to work hardening, despite the easy formation of intermetallic compounds of Ti and Cu. As a result post-treatment, the elongation was improved by more than two times from 21% to max. 53% by the Ti-Cu interface diffusion phenomenon and the average tensile strength of the 450 °C heat-treated specimens was 353 MPa. By securing high elongation while maintaining excellent tensile and yield strength through post-treatment, the formability of Ti-Cu clad plate can be greatly improved.
Nonhost Disease Resistance in Pea: Chitosan’s Suggested Role in DNA Minor Groove Actions Relative to Phytoalexin-Eliciting Anti-Cancer Compounds
Authors: Hadwiger Lee A.
Published: December 2020

A stable intense resistance called “nonhost resistance” generates a complete multiple-gene resistance against plant pathogenic species that are not pathogens of pea such as the bean pathogen, Fusarium solani f. sp. phaseoli (Fsph). Chitosan is a natural nonhost resistance response gene activator of defense responses in peas. Chitosan may share with cancer-treatment compounds, netropsin and some anti-cancer drugs, a DNA minor groove target in plant host tissue. The chitosan heptamer and netropsin have the appropriate size and charge to reside in the DNA minor groove. The localization of a percentage of administered radio-labeled chitosan in the nucleus of plant tissue in vivo indicates its potential to transport to site(s) within the nuclear chromatin (1,2). Other minor groove-localizing compounds administered to pea tissue activate the same secondary plant pathway that terminates in the production of the anti-fungal isoflavonoid, pisatin an indicator of the generated resistance response. Some DNA minor groove compounds also induce defense genes designated as “pathogenesis-related” (PR) genes. Hypothetically, DNA targeting components alter host DNA in a manner enabling the transcription of defense genes previously silenced or minimally expressed. Defense-response-elicitors can directly (a) target host DNA at the site of transcription or (b) act by a series of cascading events beginning at the cell membrane and indirectly influence transcription. A single defense response, pisatin induction, induced by chitosan and compounds with known DNA minor groove attachment potential was followed herein. A hypothesis is formulated suggesting that this DNA target may be accountable for a portion of the defense response generated in nonhost resistance.
The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix
Authors: Kong Xiang-Peng , Ren Hai-Qin , Liu Etta Y. L. , Leung Ka-Wing , Guo Shu-Chen , Duan Ran , Dong Tina T. X. , Tsim Karl W. K.
Published: December 2020

Stephaniae tetrandrae radix (STR) is a commonly used traditional Chinese medicine in alleviating edema by inducing diuresis. In the clinic, STR extracts or its components are widely used in the treatment of edema, dysuria, and rheumatism for the regulation of water metabolism. Furthermore, STR has been used in treating emotional problems for years by combining with other Chinese herbs. However, the material basis and mechanism of STR on the nervous system have not been revealed. Here, the main components of STR extracts with different extracting solvents were identified, including three major alkaloids, i.e., cyclanoline, fangchinoline, and tetrandrine. The cholinesterase inhibitory activity of STR extracts and its alkaloids was determined using the Ellman assay. Both cyclanoline and fangchinoline showed acetylcholinesterase (AChE) inhibitory activity, demonstrating noncompetitive enzyme inhibition. In contrast, tetrandrine did not show enzymatic inhibition. The synergism of STR alkaloids with huperzine A or donepezil was calculated by the median-effect principle. The drug combination of fangchinoline–huperzine A or donepezil synergistically inhibited AChE, having a combination index (CI) < 1 at Fa = 0.5. Furthermore, the molecular docking results showed that fangchinoline bound with AChE residues in the peripheral anionic site, and cyclanoline bound with AChE residues in the peripheral anionic site, anionic site, and catalytic site. In parallel, cyclanoline bound with butyrylcholinesterase (BChE) residues in the anionic site, catalytic site, and aromatic site. The results support that fangchinoline and cyclanoline, alkaloids derived from STR, could account for the anti-AChE function of STR. Thus, STR extract or its alkaloids may potentially be developed as a therapeutic strategy for Alzheimer’s patients.
Generation of Bis(ferrocenyl)silylenes from Siliranes
Authors: Pan Yang , Morisako Shogo , Aoyagi Shinobu , Sasamori Takahiro
Published: December 2020

Divalent silicon species, the so-called silylenes, represent attractive organosilicon building blocks. Isolable stable silylenes remain scarce, and in most hitherto reported examples, the silicon center is stabilized by electron-donating substituents (e.g., heteroatoms such as nitrogen), which results in electronic perturbation. In order to avoid such electronic perturbation, we have been interested in the chemistry of reactive silylenes with carbon-based substituents such as ferrocenyl groups. Due to the presence of a divalent silicon center and the redox-active transition metal iron, ferrocenylsilylenes can be expected to exhibit interesting redox behavior. Herein, we report the design and synthesis of a bis(ferrocenyl)silirane as a precursor for a bis(ferrocenyl)silylene, which could potentially be used as a building block for redox-active organosilicon compounds. It was found that the isolated bis(ferrocenyl)siliranes could be a bottleable precursor for the bis(ferrocenyl)silylene under mild conditions.
A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones
Authors: Giuglio-Tonolo Alain G. , Curti Christophe , Terme Thierry , Vanelle Patrice
Published: December 2020

Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[g]quinoxaline-5,10-diones and their uses in heterocyclic chemistry. Because of the valuable biological activities of the 1,4-diazaanthraquinone compounds, a summary of the most promising heterocyclic quinones is provided together with their antitumor properties.
7-Isopentenyloxycoumarin: What Is New across the Last Decade
Authors: Preziuso Francesca , Genovese Salvatore , Marchetti Lorenzo , Sharifi-Rad Majid , Palumbo Lucia , Epifano Francesco , Fiorito Serena
Published: December 2020

7-Isopentenyloxycoumarin is among the most widespread naturally occurring prenyloxy umbelliferone derivatives. This secondary metabolite of mixed biosynthetic origin has been typically isolated from plants belonging to several genera of the Rutaceae and Apiaceae families, comprising widely used medicinal plants and in general plants with beneficial effects on human welfare, as well as edible fruits and vegetables. Although known for quite a long time (more than 50 years), only in the last two decades has this natural compound been revealed to exert powerful and promising pharmacological properties, such as active cancer chemopreventive, antibacterial, antiprotozoal, antifungal, anti-inflammatory, neuroprotective, and antioxidant properties, among the activities best outlined in the recent literature. The aim of this comprehensive miniature review article is to detail the novel natural sources and the effects described during the last decade for 7-isopentenyloxycoumarin and what has been reported on the mechanisms of action underlying the observed biological activities of this oxyprenylated secondary metabolite. In view of the herein described data, suggestions on how to address future research on the abovementioned natural product and structurally related derivatives in the best ways according to the authors will be also provided.
CGMD Platform: Integrated Web Servers for the Preparation, Running, and Analysis of Coarse-Grained Molecular Dynamics Simulations
Authors: Marchetto Alessandro , Si Chaib Zeineb , Rossi Carlo Alberto , Ribeiro Rui , Pantano Sergio , Rossetti Giulia , Giorgetti Alejandro
Published: December 2020

Advances in coarse-grained molecular dynamics (CGMD) simulations have extended the use of computational studies on biological macromolecules and their complexes, as well as the interactions of membrane protein and lipid complexes at a reduced level of representation, allowing longer and larger molecular dynamics simulations. Here, we present a computational platform dedicated to the preparation, running, and analysis of CGMD simulations. The platform is built on a completely revisited version of our Martini coarsE gRained MembrAne proteIn Dynamics (MERMAID) web server, and it integrates this with other three dedicated services. In its current version, the platform expands the existing implementation of the Martini force field for membrane proteins to also allow the simulation of soluble proteins using the Martini and the SIRAH force fields. Moreover, it offers an automated protocol for carrying out the backmapping of the coarse-grained description of the system into an atomistic one.
Super Hydrophilic Activated Carbon Decorated Nanopolymer Foam for Scalable, Energy Efficient Photothermal Steam Generation, as an Effective Desalination System
Authors: Arshad Naila , Ahmed Iftikhar , Irshad Muhammad Sultan , Li Hong Rong , Wang Xianbao , Ahmad Shafiq , Sharaf Mohamed , Firdausi Muhammad , Zaindin Mazen , Atif Muhammad
Published: December 2020

Clean water scarcity is still an intense, prolonged global issue that needs to be resolved urgently. The solar steam generation has shown great potential with a high energy conversion efficiency for clean water production from seawater and wastewater. However, the high evaporation rate of water cannot be preserved due to the inevitable fouling of solar absorbers. Herein, a self-floatable and super hydrophilic solar-driven steam generator composed of activated carbon coated melamine foam (ACM). The deposited ACM photothermal layer exhibits outstanding solar absorption (92%) and an efficient evaporation rate of 1.27 kg m−2 h−1, along with excellent photothermal conversion efficiency (80%) as compared to commercially available primitive solar stills. The open porous assembly of melamine foam equipped with 80% flexibility (0.8 MPa) enabled smooth water transport and sustain heat accumulation within the matrix. The thermal insulation of ACM is 10 times greater than pure water. Moreover, open porous assembly of designed solar-powered steam generator rejects salt ions as well as volatile organic compounds efficiently. The low-cost and facile fabrication of photothermal based water production presents a potential solution to single step drinking water supply from various resources of the sea, the lakes and mixtures of emulsified oil and industrial wastewater.
High Electronically Conductive Tungsten Phosphate Glass-Ceramics
Authors: Renka Sanja , Klaser Teodoro , Burazer Sanja , Mošner Petr , Kalenda Petr , Šantić Ana , Moguš-Milanković Andrea
Published: December 2020

High electronically conductive tungsten phosphate glass-ceramics have been prepared by the controlled crystallization of binary 60WO3–40P2O5 glass in the temperature range from 700 to 935 °C and for 1 to 24 h. The substantial increase in the conductivity for four orders of magnitude is a result of the formation of electronically conductive W2O3(PO4)2 and WO3 phases. At low crystallization temperature the dominant W2O3(PO4)2 phase is created, whereas at 935 °C for 24 h the formation of semiconducting WO3 crystallites of an average size of 80 nm enhances the conductivity to the highest value of 1.64 × 10−4 (Ω cm)–1 at 30 °C. The course of the crystallization and its impact on this exceptionally high electronic transport of binary tungsten phosphate glass-ceramics has been discussed in detail. Since such highly electronically conductive WO3-based glass-ceramics have a great potential as cathode/anode materials in solid state batteries and as electrocatalysts in fuel cells, it is of interest to provide a novel insight into the improvement of their electrical properties.
Clinical and Neuroimaging Features in a Patient with Non-Ketotic Hyperglycemia
Authors: Zhang Yonghua , Parikh Aasheeta
Published: December 2020

Hemichorea–hemiballism (HC–HB) is a spectrum of involuntary flinging and flailing, non-patterned, irregular movements involving one side of the body. A rare dysfunction of glucose metabolism leading to a state of non-ketotic hyperglycemia (NKH) is thought to be a cause of these symptoms. In previous case studies, imaging findings have been in the basal ganglia as hyperintense lesions on magnetic resonance imaging (MRI) or hyperdensities on computerized tomography (CT). This case is unique due to abnormal findings in the MRI T2/fluid-attenuated inversion recovery (FLAIR) sequence in areas not previously reported—the thalamus and midbrain/pons. As in other NKH cases, the patient improved both clinically and radiologically. In patients with uncontrolled diabetes and abnormal movements, monitoring of blood glucose is imperative as it can lead to recognition of HC–HB. Other etiologies, including stroke, neoplasm, demyelination, and inflammatory processes, have uncertain prognoses with unfavorable outcomes. The prognosis for NKH is usually favorable, and thus important to identify.
The Impact of Low-Level Iron Supplements on the Faecal Microbiota of Irritable Bowel Syndrome and Healthy Donors Using In Vitro Batch Cultures
Authors: Poveda Carlos , Pereira Dora I. A. , Lewis Marie C. , Walton Gemma E.
Published: December 2020

Ferrous iron supplementation has been reported to adversely alter the gut microbiota in infants. To date, the impact of iron on the adult microbiota is limited, particularly at low supplementary concentrations. The aim of this research was to explore the impact of low-level iron supplementation on the gut microbiota of healthy and Irritable Bowel Syndrome (IBS) volunteers. Anaerobic, pH-controlled in vitro batch cultures were inoculated with faeces from healthy or IBS donors along with iron (ferrous sulphate, nanoparticulate iron and pea ferritin (50 μmol−1 iron)). The microbiota were explored by fluorescence in situ hybridisation coupled with flow cytometry. Furthermore, metabolite production was assessed by gas chromatography. IBS volunteers had different starting microbial profiles to healthy controls. The sources of iron did not negatively impact the microbial population, with results of pea ferritin supplementation being similar to nanoparticulate iron, whilst ferrous sulphate led to enhanced Bacteroides spp. The metabolite data suggested no shift to potentially negative proteolysis. The results indicate that low doses of iron from the three sources were not detrimental to the gut microbiota. This is the first time that pea ferritin fermentation has been tested and indicates that low dose supplementation of iron is unlikely to be detrimental to the gut microbiota.
The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study
Authors: Nieto-Ruiz Ana , Diéguez Estefanía , Sepúlveda-Valbuena Natalia , Herrmann Florian , Cerdó Tomás , López-Torrecillas Francisca , De-Castellar Roser , Jiménez Jesús , Pérez-García Miguel , Miranda María T. , Catena Andrés , García-Santos José A. , Bermúdez Mercedes G. , Campoy Cristina
Published: December 2020

Although early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Different statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological affective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial effects on internalizing and total problem rate in their offspring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development.
Efficacy of Ingesting an Oral Rehydration Solution after Exercise on Fluid Balance and Endurance Performance
Authors: Fan Priscilla Weiping , Burns Stephen F. , Lee Jason Kai Wei
Published: December 2020

This study investigated the efficacy of ingesting an oral rehydration solution (DD) that has a high electrolyte concentration after exercise on fluid balance and cycling performance in comparison with a sports drink (SD) and water (WA). Nine healthy males aged 24 ± 2 years (mean ± SD), with peak oxygen uptake (VO2 peak) 55 ± 6 mL·kg−1·min−1 completed three experimental trials in a randomised manner ingesting WA, SD (carbohydrates: 62 g·L−1, sodium: 31 ± 3 mmol·L−1) or DD (carbohydrates: 33 g·L−1, sodium: 60 ± 3 mmol·L−1). On all trials, fluid was ingested during 75 min cycling at 65% VO2 peak (temperature: 30.4 ± 0.3 °C, relative humidity: 76 ± 1%, simulated wind speed: 8.0 ± 0.6 m·s−1) and during 2 h of recovery (temperature: 23.0 ± 1.0 °C, relative humidity: 67 ± 2%), with the total volume equivalent to 150% of sweat loss during the ride. A 45 min pre-load cycling time trial at a 65% VO2 peak followed by a 20 km time trial was conducted after a further 3 h of recovery. Fluid retention was higher with DD (30 ± 15%) than WA (−4 ± 19%; p < 0.001) and SD (10 ± 15%; p = 0.002). Mean ratings of palatability were similar among drinks (WA: 4.25 ± 2.60; SD: 5.61 ± 1.79; DD: 5.40 ± 1.58; p = 0.33). Although time trial performance was similar across all three trials (WA: 2365 ± 321 s; SD: 2252 ± 174 s; DD: 2268 ± 184 s; p = 0.65), the completion time was faster in eight participants with SD and seven participants with DD than with WA. Comparing SD with DD, completion time was reduced in five participants and increased in four participants. DD was more effective at restoring the fluid deficit during recovery from exercise than SD and WA without compromising the drink’s palatability with increased sodium concentration. Most individuals demonstrated better endurance exercise time trial performance with DD and SD than with WA.
Physicochemical Properties and Hematocompatibility of Layered Double Hydroxide-Based Anticancer Drug Methotrexate Delivery System
Authors: Jung Sang-Yong , Kim Hyoung-Mi , Hwang Soonjae , Jeung Do-Gak , Rhee Ki-Jong , Oh Jae-Min
Published: December 2020

A layered double hydroxide (LDH)-based anticancer delivery system was investigated in terms of crystalline phase, particle size, hydrodynamic radius, zeta potential, etc. through in vitro and in vivo study. Size controlled LDH with anticancer drug methotrexate (MTX) incorporation was successfully prepared through step-by-step hydrothermal reaction and ion-exchange reaction. The MTX-LDH was determined to have a neutral surface charge and strong agglomeration in the neutral aqueous condition due to the surface adsorbed MTX; however, the existence of proteins in the media dramatically reduced agglomeration, resulting in the hydrodynamic radius of MTX-LDH being similar to the primary particle size. The protein fluorescence quenching assay exhibited that MTX readily reduced the fluorescence of proteins, suggesting that the interaction between MTX and proteins was strong. On the other hand, MTX-LDH showed much less binding constant to proteins compared with MTX, implying that the protein interaction of MTX was effectively blocked by the LDH carrier. The in vivo hemolysis assay after intravenous injection of MTX-LDH showed neither significant reduction in red blood cell number nor membrane damage. Furthermore, the morphology of red blood cells in a mouse model did not change upon MTX-LDH injection. Scanning electron microscopy showed that the MTX-LDH particles were attached on the blood cells without serious denaturation of cellular morphology, taking advantage of the cell hitchhiking property.
Rheological and Drug Delivery Characteristics of Poloxamer-Based Diclofenac Sodium Formulations for Chronic Wound Site Analgesia
Authors: Russo Jackson , Fiegel Jennifer , Brogden Nicole K.
Published: December 2020

Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience. A topical dosage form would be optimal to treat this pain. Poloxamer 407, a thermosensitive polymer that is a liquid at low temperatures but gels at higher temperatures, is well suited to administer topical analgesics to chronic wound sites. The goal of this study was to evaluate the gelation and drug delivery properties of poloxamer 407 gels containing diclofenac sodium for potential use in chronic wound analgesic delivery. The gelation properties of poloxamer formulations were evaluated rheologically. Drug delivery properties of poloxamers loaded with diclofenac sodium were evaluated using snakeskin dialysis membranes, intact porcine ear skin, and porcine ear skin impaired via tape stripping. A commercial gel product and a solution of diclofenac sodium in water were used as control formulations. Poloxamer concentration and gelation temperature varied inversely, and the addition of higher concentrations of diclofenac sodium correlated to significant increases in poloxamer gelation temperature. Poloxamer solutions were effective in limiting the permeation of diclofenac sodium through membranes with impaired barrier properties, and delivery of diclofenac sodium from poloxamer 407 did not vary significantly from delivery observed from the commercial gel product. The amount of drug delivered in 24 h did not change significantly with changes in poloxamer 407 concentration. The results of this study indicate that poloxamer 407 may be a useful formulation component for administration of an analgesic product to a chronic wound site.
Thermoresponsive Shape Memory Fibers for Compression Garments
Authors: Tonndorf Robert , Aibibu Dilbar , Cherif Chokri
Published: December 2020

Their highly deformable properties make shape memory polymers (SMP) a promising component for the development of new compression garments. The shape memory effect (SME) can be observed when two polymers are combined. In here, polycaprolactone (PCL) and thermoplastic polyurethane (TPU) were melt spun in different arrangement types (blend, core-sheath, and island-in-sea), whereas the best SME was observed for the blend type. In order to trigger the SME, this yarn was stimulated at a temperature of 50 °C. It showed a strain fixation of 62%, a strain recovery of 99%, and a recovery stress of 2.7 MPa.
Afghan-Hazara Migration and Relocation in a Globalised Australia
Authors: Parkes Aidan
Published: December 2020

This study examines a set of unique isolated lived-experiences to offer some general observations concerning Afghan-Hazara migration, relocation, and individuation in Australia. Culture may have the appearance of immutability. However, like any social formation, it is produced, reproduced, and contested through time. Everyone is an individual, and while we speak of the impact and culture, lived-experience is very different. People always have choices they can make about what lessons they might derive from experiences. If one faces discrimination within the realm of the state, which is historically well documented where Hazaras are concerned, one begins looking for alternative pathways to advancement. These include personalised networks in religious communities, education, and business entrepreneurship. The study analyses the fluid nature of belief systems, and the multiplicity of ways lived-experience shapes individuation and reshapes identity through pathways to advancement in a globalising Australia.
The Relationship between Psycholinguistic Features of Religious Words and Core Dimensions of Religiosity: A Survey Study with Japanese Participants
Authors: Kambara Toshimune , Umemura Tomotaka , Ackert Michael , Yang Yutao
Published: December 2020

Previous studies have reported that religious words and religiosity affect mental processes and behaviors. However, it is unclear what psycholinguistic features of religious words (e.g., familiarity, imageability, and emotional aspects) are associated with each dimension of personal religiosity (intellect, ideology, public practice, private practice, and experience). The purpose of this study was to examine whether and how the above-mentioned psycholinguistic features of religious words correlate with each of the core dimensions of religiosity. Japanese participants evaluated four psycholinguistic features of twelve religious words using a 5-point Semantic Differential scale for familiarity and imageability and a 9-point Self-Assessment Manikin (SAM) scale for emotional valence and emotional arousal. The participants also rated their own religiosity using the Japanese version of the Centrality of Religiosity Scale (JCRS). The results of the study revealed that (1) the scales measuring the psycholinguistic features of religious words were statistically reliable; (2) the JCRS was reliable; (3) the familiarity, emotional valence, and emotional arousal of religious words and each mean dimensional score of the JCRS score correlated positively with each other; and (4) highly religious people had higher familiarity and higher emotional arousal to religious words than non-religious people, whereas highly religious people had higher emotional valence to religious words in comparison with non-religious and religious people. In addition, religious people had higher familiarity to religious words than non-religious people. Taken together, these findings suggest that psycholinguistic features of religious words contribute to the detection of religiosity.