bluuebunny/crossref_metadata_2025 huggingface dataset:
Aberrant Claudin-6–Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α
Authors: Kojima Manabu , Sugimoto Kotaro , Kobayashi Makoto , Ichikawa-Tomikawa Naoki , Kashiwagi Korehito , Watanabe Takafumi , Soeda Shu , Fujimori Keiya , Chiba Hideki
Published: March 2021

Cell adhesion proteins not only maintain tissue integrity, but also possess signaling abilities to organize diverse cellular events in a variety of physiologic and pathologic processes; however, the underlying mechanism remains obscure. Among cell adhesion molecules, the claudin (CLDN) family is often aberrantly expressed in various cancers, but the biological relevance and molecular basis for this observation have not yet been established. Here, we show that high CLDN6 expression accelerates cellular proliferation and migration in two distinct human endometrial cancer cell lines in vitro. Using a xenograft model, we also revealed that aberrant CLDN6 expression promotes tumor growth and invasion in endometrial cancer tissues. The second extracellular domain and Y196/200 of CLDN6 were required to recruit and activate Src-family kinases (SFK) and to stimulate malignant phenotypes. Knockout and overexpression of ESR1 in endometrial carcinoma cells showed that the CLDN6-adhesion signal links to estrogen receptor α (ERα) to advance tumor progression. In particular, aberrant CLDN6–ERα signaling contributed to collective cell behaviors in the leading front of endometrial cancer cells. Importantly, we demonstrate that CLDN6/SFK/PI3K-dependent AKT and SGK (serum- and glucocorticoid-regulated kinase) signaling in endometrial cancer cells targets Ser518 in the human ERα to activate ERα transcriptional activity in a ligand-independent manner, thereby promoting tumor progression. Furthermore, CLDN6, at least in part, also regulated gene expression in an ERα-independent manner.

Implications:

The identification of this machinery highlights regulation of the transcription factors by cell adhesion to advance tumor progression.
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy
Authors: Montfort Anne , Bertrand Florie , Rochotte Julia , Gilhodes Julia , Filleron Thomas , Milhès Jean , Dufau Carine , Imbert Caroline , Riond Joëlle , Tosolini Marie , Clarke Christopher J. , Dufour Florent , Constantinescu Andrei A. , Junior Nilton De França , Garcia Virginie , Record Michel , Cordelier Pierre , Brousset Pierre , Rochaix Philippe , Silvente-Poirot Sandrine , Therville Nicole , Andrieu-Abadie Nathalie , Levade Thierry , Hannun Yusuf A. , Benoist Hervé , Meyer Nicolas , Micheau Olivier , Colacios Céline , Ségui Bruno
Published: March 2021

Dysregulation of lipid metabolism affects the behavior of cancer cells, but how this happens is not completely understood. Neutral sphingomyelinase 2 (nSMase2), encoded by SMPD3, catalyzes the breakdown of sphingomyelin to produce the anti-oncometabolite ceramide. We found that this enzyme was often downregulated in human metastatic melanoma, likely contributing to immune escape. Overexpression of nSMase2 in mouse melanoma reduced tumor growth in syngeneic wild-type but not CD8-deficient mice. In wild-type mice, nSMase2-overexpressing tumors showed accumulation of both ceramide and CD8+ tumor-infiltrating lymphocytes, and this was associated with increased level of transcripts encoding IFNγ and CXCL9. Overexpressing the catalytically inactive nSMase2 failed to alter tumor growth, indicating that the deleterious effect nSMase2 has on melanoma growth depends on its enzymatic activity. In vitro, small extracellular vesicles from melanoma cells overexpressing wild-type nSMase2 augmented the expression of IL12, CXCL9, and CCL19 by bone marrow–derived dendritic cells, suggesting that melanoma nSMase2 triggers T helper 1 (Th1) polarization in the earliest stages of the immune response. Most importantly, overexpression of wild-type nSMase2 increased anti–PD-1 efficacy in murine models of melanoma and breast cancer, and this was associated with an enhanced Th1 response. Therefore, increasing SMPD3 expression in melanoma may serve as an original therapeutic strategy to potentiate Th1 polarization and CD8+ T-cell–dependent immune responses and overcome resistance to anti–PD-1.
Detection of water quality in crayfish ponds with IoT
Authors: Abdurrasyid Abdurrasyid , Indrianto Indrianto , Indah Susanti Meilia Nur , Purwanto Yudhi S.
Published: March 2021

Data from the Central Bureau of Statistics shows that during the first quarter of 2014 to 2019, the tendency of Indonesian crayfish export increases by an average of 3.54% in 2019 and reach 7.09 million USD. This number still fails to meet the global market demand caused by poor water quality due to cultivators’ lack of experience and education. Two parameters measured in water quality are temperature and pH. Thus, a device was made using IoT to maintain those conditions in order to increase the viability of the crayfish in the pond. The perceptron method is used to classify water quality based on those parameters. To send the data, ESP8266 is used as an intermediary for Arduino and cloud server. The result is that the information about the ponds’ condition can be seen via a smartphone. The method gives a value of 98.06% accurate in determining water quality.
Secure outage probability of cognitive radio network relying non-orthogonal multiple access scheme
Authors: Le Chi-Bao , Do Dinh-Thuan
Published: March 2021

This paper studies the secondary network relying relay selection to transmit signal from the secondary source (base station) to two destinations. Especially, two destinations are required non-orthogonal multiple access (NOMA) scheme and it benefits to implementation of the Internet of Things (IoT) systems. However, eavesdropper over-hears signal related link from selected relay to destination. This paper measure secure performance via metric, namely secure outage probability (SOP). In particular, signal to noise ratio (SNR) criterion is used to evalute SOP to provide reliable transmission to the terminal node. Main results indicates that the considered scheme provides performance gap among two signals at destination. The exactness of derived expressions is confirmed via numerical simulation.
A new T-circuit model of wind turbine generator for power system steady state studies
Authors: Gianto Rudy , Hie Khwee Kho
Published: March 2021

Modeling of wind power plant (WPP) is a crucial issue in power system studies. In this paper, a new model of WPP for steady state (i.e. load flow) studies is proposed. Similar to the previous T-circuit based models, it is also developed based on equivalent T-circuit of the WPP induction generator. However, unlike in the previous models, the mathematical formulation of the new model is shorter and less complicated. Moreover, the derivation of the model in the present work is also much simpler. Only minimal mathematical operations are required in the process. Furthermore, the rotor voltage value of the WPP induction generator is readily available as an output of the proposed new model. This rotor voltage value can be used as a basis to calculate the induction generator slip. Validity of the new method is tested on a representative 9-bus electrical power system installed with WPP. Comparative studies between the proposed method (new model) and other method (previous model) are also presented
Towards a formal analysis of the multi-robot task allocation problem using set theory
Authors: Zitouni Farouq , Maamri Ramdane , Harous Saad
Published: March 2021

Nowadays, the multi-robot task allocation problem is one of the most challenging problems in multi-robot systems. It concerns the optimal assignment of a set of tasks to several robots while optimizing a given criterion subject to some constraints. This problem is very complex, particularly when handling large groups of robots and tasks. We propose a formal analysis of the task allocation problem in a multi-robot system, based on set theory concepts. We believe that this analysis will help researchers understand the nature of the problem, its time complexity, and consequently develop efficient solutions. Also, we used that formal analysis to formulate two well-known taxonomies of multi-robot task allocation problems. Finally, a generic solving scheme of multi-robot task allocation problems is proposed and illustrated on assigning papers to reviewers within a journal.
Measuring prevailing practices of healthcare professional on electronic health record through the lens of Iraq
Authors: Saare Murtaja Ali , Mahdi Alia Ahmed , Lashari Saima Anwar , Sari Sari Ali , Hamid Norhamreeza Abdul
Published: March 2021

Paper based approach to clinical documentation such as handwritten notes among health care providers are cause of errors in medical field. Therefore, health record system needs to be replaced with electronic health record (EHR). Many health professionals in developing countries specifically in Iraq refuse to use the systems implemented for their benefits due to many reasons. Thus, the use of electronic services is important for successful electronic health implementations. Therefore, this study is intended to identify the main factors affecting the intention of use of the electronic health record in Iraq. Health professional staff who work in the main hospital in Dhi-Qar is chosen because this province is the first local province that implemented many electronic projects. The present study examined use of user acceptance of technology, based on the technology acceptance model (TAM). Moreover, the quantitative method approach for data collection using survey from staff who work in the main hospital in Dhi-Qar. Data was analyzed using Structural Equation Modeling using AMOS. The results indicated significant relationship between Ease of Use, Usefulness, Usefulness, Attitude, and Intention of use of EHR. These finding have implementation for decision makers in Iraq government to improve future implementation of e-health services.
Advanced modulation coding schemes for an optical transceiver systems–based OWC communication channel model
Authors: El-Hageen Hazem M. , Alatwi Aadel M. , Rashed Ahmed Nabih Zaki
Published: March 2021

This paper examines advanced modulation coding schemes for an optical transceiver systems–based optical wireless communication (OWC) channel model. These modulation techniquesinclude On-Off keying and return to zero (RZ)/non–return to zero (NRZ) coding. The signal power level against time and frequency spectral variations are measured. The max. Q factor and min. bit error rate (BER) are estimated and clarified for each modulation code scheme by using an optisystem simulation model. Transmission bit rates of up to 40 Gb/s can be achieved for possible distances up to 500 km with acceptable Q factor. The received power and max. Q factor are measured and clarified with OWC distance variations. The On-Off keying modulation code scheme resulted in better performance than the other modulation code schemes did.
Locating and sizing of capacitor banks and multiple DGs in distribution system to improve reliability indexes and reduce loss using ABC algorithm
Authors: Ahmadi Kamarposhti Mehrdad , Mousavi Khormandichali Seyed Mohsen , Ahmed Solyman Ahmed Amin
Published: March 2021

DG sources have been introduced as one of the most widely used and effective methods among various methods providing losses reduction in power systems. In this paper, the artificial bee colony algorithm has been employed with the aim of determining location and capacity of distributed generations (DGs) and capacitor banks (CBs) in distribution systems. The proposed objective function includes power losses and ENS reliability index, which is used by deploying weight coefficients as objective function in the algorithms. Accordingly, the standard 37-bus networks have been used for studies. The simulation results demonstrate that the artificial bee colony algorithm is more effective in all sections and has higher capability in reducing losses and improving reliability as well.
Live migration using checkpoint and restore in userspace (CRIU): Usage analysis of network, memory and CPU
Authors: Widjajarto Adityas , Jacob Deden Witarsyah , Lubis Muharman
Published: March 2021

Currently, cloud service providers have used a variety of operational mechanisms to support the company's business processes. Therefore, the services are stored on the company's server, which presents in the form of infrastructure, platform, software, and function. There are several vulnerabilities that have been faced in the implementation such as system failure, natural disasters, human errors, or attacks from unauthorized parties. In addition, the time of unavailability of services can be minimized by doing an LM, in which many servers have been used the containers to behave like a service provider. Actually, its existence replaces the virtual machine that requires more resources although the process only can be done through docker with checkpoint and restore in userspace (CRIU). In this research, LM processes are done to the docker container using CRIU by analyzing the quality of service (QoS), memory, and CPU usage. Thus, the simulation is carried out by establishing the LM using 2 (two) different platforms through scenarios with one and three containers respectively. The performance analysis results aim to examine several indicators in comparison with the achievable result to reduce problems that occurred in the cloud service.
Threshold benchmarking for feature ranking techniques
Authors: Malhotra Ruchika , Sharma Anjali
Published: March 2021

In prediction modeling, the choice of features chosen from the original feature set is crucial for accuracy and model interpretability. Feature ranking techniques rank the features by its importance but there is no consensus on the number of features to be cut-off. Thus, it becomes important to identify a threshold value or range, so as to remove the redundant features. In this work, an empirical study is conducted for identification of the threshold benchmark for feature ranking algorithms. Experiments are conducted on Apache Click dataset with six popularly used ranker techniques and six machine learning techniques, to deduce a relationship between the total number of input features (N) to the threshold range. The area under the curve analysis shows that ≃ 33-50% of the features are necessary and sufficient to yield a reasonable performance measure, with a variance of 2%, in defect prediction models. Further, we also find that the log2(N) as the ranker threshold value represents the lower limit of the range.
Automated diagnosis of attacks in internet of things using machine learning and frequency distribution techniques
Authors: Ghrib Toufik , Benmohammed Mohamed , Pandey Purnendu.Shekhar
Published: March 2021

The Internet of Things (IoT) is the interconnection of things around us to make our daily process more efficient by providing more comfort and productivity. However, these connections also reveal a lot of sensitive data. Therefore, thinking about the methods of information security and coding are important as the security approaches that rely heavily on coding are not a strong match for these restricted devices. Consequently, this research aims to contribute to filling this gap, which adopts machine learning techniques to enhance network-level security in the low-power devices that use the lightweight MQTT protocol for their work. This study used a set of tools tools and, through various techniques, trained the proposed system ranging from Ensemble methods to deep learning models. The system has come to know what type of attack has occurred, which helps protect IoT devices. The log loss of the Ensemble methods is 0.44, and the accuracy of multi-class classification is 98.72% after converting the table data into an image set. The work also uses a Convolution Neural Network, which has a log loss of 0.019 and an accuracy of 99.3%. It also aims to implement these functions in IDS.
An in-depth exploration of Bangla blog post classification
Authors: Islam Tanvirul , Prince Ashik Iqbal , Khan Md. Mehedee Zaman , Jabiullah Md. Ismail , Habib Md. Tarek
Published: March 2021

Bangla blog is increasing rapidly in the era of information, and consequently, the blog has a diverse layout and categorization. In such an aptitude, automated blog post classification is a comparatively more efficient solution in order to organize Bangla blog posts in a standard way so that users can easily find their required articles of interest. In this research, nine supervised learning models which are Support Vector Machine (SVM), multinomial naïve Bayes (MNB), multi-layer perceptron (MLP), k-nearest neighbours (k-NN), stochastic gradient descent (SGD), decision tree, perceptron, ridge classifier and random forest are utilized and compared for classification of Bangla blog post. Moreover, the performance on predicting blog posts against eight categories, three feature extraction techniques are applied, namely unigram TF-IDF (term frequency-inverse document frequency), bigram TF-IDF, and trigram TF-IDF. The majority of the classifiers show above 80% accuracy. Other performance evaluation metrics also show good results while comparing the selected classifiers.
Prólogo terminável e interminável (sobre as primeiras peças de Peter Handke)
Authors: Kon Artur Sartori
Published: March 2021

Abordando o conjunto das chamadas “peças de fala” (Sprechstücke), as primeiras quatro obras escritas para o teatro ainda nos anos 60 por Peter Handke, Prêmio Nobel de Literatura de 2019, o ensaio busca localizar nelas mais do que o jogo autorreferencial alienado censurado por muitos num suposto pós-modernismo. Relacionando o projeto do autor com uma tradição modernista propriamente austríaca e com as preocupações de uma possível filosofia política da linguagem, investigamos essa dramaturgia como uma operação crítica em relação a um funcionamento coercitivo da linguagem, para ao fim relacionar esse interesse com sua posição na história do teatro, propondo seu papel chave para compreender a cena contemporânea.
Modernidade e indeterminação em “O lobo da estepe”
Authors: Lopes Juliana
Published: March 2021

Dada a posição excêntrica de Hermann Hesse dentro da literatura de língua alemã no século XX, quase como um “outsider” retrógrado, o objetivo do presente artigo é tentar situar O lobo da estepe (1927) nas discussões sobre a “modernidade literária”. Para esse fim, serão realizadas considerações que demonstram como o livro representa um sujeito no contexto do mundo moderno dos anos 1920 e como o romance adota uma estrutura multiperspectiva que reflete os novos modos de representação que começaram a ser explorados na forma literária moderna. Essa estrutura será analisada com base nas categorias narratológicas propostas por Genette (1995), apontando as três diferentes perspectivas sobre o protagonista Harry Haller presentes no livro: a do “Prefácio do editor”, “As Anotações de Harry Haller” e o “Tratado do lobo da estepe”. A partir da análise, discutir-se-á a possibilidade de entender os acontecimentos narrados nas “Anotações” como frutos da imaginação ou como depoimento autobiográfico do protagonista. No primeiro caso, o livro se encaixaria na categoria do realismo, no segundo, na literatura fantástica. Por fim, serão comparadas as diversas edições do livro – que apresentam diferenças significativas – de modo a evidenciar como a estrutura narrativa pode favorecer a classificação do romance como fantástico.
Hipnosis, caos y violencia: sobre la dialéctica amo-esclavo en los personajes de El Gabinete del Dr. Caligari
Authors: Ibarra Camila Vidal
Published: March 2021

El expresionismo alemán nace como tendencia en el período de entreguerras, y es en ese contexto histórico, político y social donde ve la luz la película El gabinete del Dr. Caligari (1920). El presente artículo se propone analizar dicho film prestando especial atención a la relación interpersonal que se establece entre los personajes Caligari y Cesare. Resultan fundamentales para ello los planteos sobre estética, teoría del cine y filosofía acuñados por Siegfried Kracauer. El objetivo de este trabajo es entonces mostrar de qué manera la dialéctica hegeliana permite reflexionar sobre cómo el cine alemán ha expresado miedos y tensiones sociales que luego serán materializados en la realidad política y social de la Alemania del momento.
La recepción de Las penas del joven Werther de J. W. Goethe en el contexto de la Segunda Ilustración. La reseña de Friedrich Blanckenburg
Authors: Koval Martín Ignacio
Published: March 2021

Se discute aquí la reseña de Friedrich Blanckenburg sobre Las penas del joven Werther (1774) de J. W. Goethe. La reseña, de la que ofrecemos la traducción al español de varios pasajes, fue publicada unos meses más tarde que la polémica y revolucionaria novela de Goethe y constituye un documento valioso no solo de su recepción, sino también de la teorización acerca del género en el contexto de finales de la Segunda Ilustración en Alemania. Da cuenta, en efecto, de un rasgo central de este periodo: la recepción sensibilista, empfindsam, que tendría un efecto benefactor sobre la sociabilidad y las costumbres. Además, en una relación en cierto modo ambigua con este llamado a la empatía socialmente útil del crítico y del lector, el autor presenta elementos que señalan llamativamente hacia una doctrina de la autonomía de la esfera estética. Lo que queda sin saberse es si se trata de una “desprolijidad” de la reseña o de una lúcida interpretación de la “voz doble” que plantea Goethe en su famosa novela epistolar.
Política de gestão de coleções: museu universitário, curadoria indígena e processo colaborativo
Authors: Cury Marília Xavier
Published: March 2021

Os museus carregam uma herança colonialista colocada em cheque por modelos teóricos e metodológicos, sob a orientação das áreas sociais e humanas. O artigo visa a discutir como o museu universitário pode propor novos parâmetros pela ação colaborativa. A discussão centra-se na gestão de acervo, “lugar” de cruzamento das políticas institucionais. Trataremos da curadoria da exposição “Resistência já! Fortalecimento e união das culturas indígenas – Kaingang, Guarani Nhandewa e Terena”, que promoveu o entendimento indígena sobre museu universitário, a autorrepresentação e a intenção de doação de objetos contemporâneos. O contexto é o Museu de Arqueologia e Etnologia (USP) e os atores são os Kaingang, Guarani Nhandewa e Terena das Terras Indígenas Araribá, Icatu e Vanuíre, em São Paulo. Queremos apresentar as expectativas indígenas na musealização, para refletir sobre o papel do museu universitário na produção de sentidos preservacionistas e as motivações para a doação, colocando lado a lado herança elegado. Também, como o museu vê a representação e a autorrepresentação, como incorpora novos processos em face de políticas e procedimentos a serem reestruturados. O debate segue nos aspectos antropológicos e museológicos que estruturam novos pensamentos e possibilidades de práxis para os museus.
Coleções visitáveis: relatos de experiência entre as prática de ensino sobre documentação em museus e de pesquisa para a gestão na UNIRIO
Authors: Mendonça Elizabete de Castro , Sousa Jaddy Nascimento Parovszky Gomes de
Published: March 2021

Este artigo apresenta resultados parciais do projeto de ensino “Gestão de coleções: análise sobre documentação de objetos associados aos conhecimentos tradicionais populares sob tutela da UNIRIO e aplicabilidade do sistema In Arte”, vinculado ao Núcleo Multidimensional de Gestão do Patrimônio e de Documentação em Museus (NUGEP/UNIRIO), tendo como problemática a qualificação de informações sobre as coleções universitárias. Seu objetivo é explicitar o processo de documentação e qualificação de dados das coleções visitáveis da UNIRIO a partir da experiência entre as práticas de ensino de documentação museológica e de pesquisa para a gestão das coleções, tendo como foco o acervo da Biblioteca Central – especialmente os objetos que pertenceram ao professor Pernambuco de Oliveira, que hoje integram a Coleção de Artesanato e Arte Popular. O trabalho inicial de documentação do acervo foi realizado a partir da revisão do inventário e consequente quantificação do acervo. Desde 2018, a coleção é catalogada pelos discentes da disciplina Informação e Documentação Museológica I, do curso de graduação em Museologia, no sistema de gestão de coleções In Arte Online. As ações acadêmicas de catalogação, potencializadas pelo uso do software de gestão de coleções, contribuem para a formação teórico-prática dos futuros profissionais de museologia e promovem o reconhecimento e a identificação das coleções da própria universidade, podendo auxiliar na definição de diretrizes sobre políticas de gestão dos seus bens culturais.
Museu da Farmácia da Universidade Federal de Ouro Preto: análise das fichas de registro e documentação da coleção de medicamentos
Authors: Hottes Sarha Dias , Oliveira Ana Cristina Audebert Ramos de
Published: March 2021

A documentação museológica é um dos eixos do museu e está presente nas ações de registro, catalogação, pesquisa e comunicação do acervo. O artigo apresenta um estudo da documentação museológica tendo como foco as fichas de registro atualmente utilizadas na Coleção de Medicamentos do Museu da Farmácia da Universidade Federal de Ouro Preto. A metodologia consiste em pesquisa bibliográfica na qual discutimos os alcances teóricos e práticos do tratamento da informação em museus, a formação dos museus universitários e alguns conceitos correlatos. Realizamos pesquisa in loco e estudo da Coleção de Medicamentos e suas fichas de registro com o intuito de averiguar se os campos atendem às necessidades informacionais específicas dessa tipologia de coleção. Identificamos que, ao longo do tempo, as fichas aplicadas à coleção passaram por mudanças tanto na estrutura, organização e denominação dos campos quanto na metodologia de preenchimento. Como resultado propomos um novo modelo de ficha de registro com capacidade de disponibilizar mais informações sobre a coleção e elaboramos um manual para a atual ficha da instituição.
O descompasso entre a estrutura acadêmica e a estrutura museal em museus universitários: o caso do Museu Nacional (UFRJ)
Authors: Reis Silvia , Witovisk Luciana , Targino Mariane , Britto Marcelo , Santos Fernanda Pires
Published: March 2021

O Museu Nacional foi criado em 1818, por D. João VI. Em 200 anos passou pela estruturação de suas coleções, pela incorporação à Universidade do Brasil, em 1946, atual Universidade Federal do Rio de Janeiro, e tornou-se referência nacional e internacional nas áreas da História Natural e Antropologia por meio de suas coleções e excelência em ensino, pesquisa e extensão. O incêndio ocorrido em 2 de setembro de 2018 marcou mais um importante capítulo da sua história – a luta pela reconstrução. Parte desse esforço foi a composição de uma comissão de servidores que se debruçou sobre a revisão e construção de um novo regimento para a instituição. Assim, este trabalho traz à luz análises sobre a  complexidade da estrutura do Museu Nacional e debate alguns problemas práticos que dificultam a sua plena realização como museu e parte integrante de uma estrutura universitária. Tal debate é extensível e imprescindível para os museus universitários, onde a estrutura museal pode ser passível de limitações por uma estrutura universitária voltada para unidades acadêmicas padrão ou órgãos suplementares não autônomos, e que não contempla as particularidades do funcionamento de um museu. Por fim, é proposta a criação de uma estrutura museal-acadêmica, onde todas as categorias de servidores públicos poderiam atuar de forma colaborativa, em prol de uma instituição diversa, dinâmica, plural, em diálogo aberto com a universidade e a sociedade, pronta para enfrentar os novos paradigmas do século XXI.
Mudanças no peso corporal na coorte NutriNet Brasil durante a pandemia de covid-19
Authors: Costa Caroline dos Santos , Steele Eurídice Martínez , Leite Maria Alvim , Rauber Fernanda , Levy Renata Bertazzi , Monteiro Carlos Augusto
Published: March 2021

Este estudo descreve modificações no peso corporal de participantes da coorte NutriNet Brasil (n = 14.259) ocorridas durante a pandemia de covid-19. Foram analisados dados informados em período anterior ao início da pandemia (26/01/2020 a 18/03/2020) e cerca de 6 meses após (14/09/2020 a 19/10/2020). O ganho de peso ≥ 2 kg alcançou 19,7% dos participantes, mostrando-se diretamente associado ao sexo masculino, à menor escolaridade e à presença prévia de excesso de peso, sendo inversamente associado à idade. A perda de peso ≥ 2kg alcançou 15,2% dos participantes, mostrando-se diretamente associada ao sexo masculino e à presença prévia de excesso de peso, sendo inversamente associada à idade.
Clinical Profile and Health Disparities in a Multiethnic Cohort of Patients With Hypertrophic Cardiomyopathy
Authors: Butters Alexandra , Semsarian Caitlin R. , Bagnall Richard D. , Yeates Laura , Stafford Fergus , Burns Charlotte , Semsarian Christopher , Ingles Jodie
Published: March 2021

Background:

Clinical studies of hypertrophic cardiomyopathy are over-represented by individuals of European ethnicity, with less known about other ethnic groups. We investigated differences between patients in a multiethnic Australian hypertrophic cardiomyopathy population.

Methods:

We performed a retrospective cohort study of 836 unrelated hypertrophic cardiomyopathy probands attending a specialized clinic between 2002 and 2020. Major ethnic groups were European (n=611), East Asian (n=75), South Asian (n=58), and Middle Eastern and North African (n=68). The minor ethnicity groups were Oceanian (n=9), People of the Americas (n=7), and African (n=8). One-way ANOVA with Dunnett post hoc test and Bonferroni adjustment were performed.

Results:

Mean age of the major ethnic groups was 54.9±16.9 years, and 527 (65%) were male. Using the European group as the control, East Asian patients had a lower body mass index (29 versus 25 kg/m
2
,
P
<0.0001). South Asians had a lower prevalence of atrial fibrillation (10% versus 31%,
P
=0.024). East Asians were more likely to have apical hypertrophy (23% versus 6%,
P
<0.0001) and Middle Eastern and North African patients more likely to present with left ventricular outflow tract obstruction (46% versus 34%,
P
=0.0003). East Asians were less likely to undergo genetic testing (55% versus 85%,
P
<0.0001) or have an implantable cardioverter-defibrillator implanted (19% versus 36%,
P
=0.037). East Asians were more likely to have a causative variant in a gene other than
MYBPC3
or
MYH7
, whereas Middle Eastern and North African and South Asians had the highest rates of variants of uncertain significance (27% and 21%,
P
<0.0001).

Conclusions:

There are few clinical differences based on ethnicity, but importantly, we identify health disparities relating to access to genetic testing and implantable cardioverter-defibrillator use. Unless addressed, these gaps will likely widen as we move towards precision-medicine–based care of individuals with hypertrophic cardiomyopathy.
Right Ventricular Ejection Fraction for the Prediction of Major Adverse Cardiovascular and Heart Failure-Related Events
Authors: Purmah Yanish , Lei Lucy Y. , Dykstra Steven , Mikami Yoko , Cornhill Aidan , Satriano Alessandro , Flewitt Jacqueline , Rivest Sandra , Sandonato Rosa , Seib Michelle , Lydell Carmen P. , Howarth Andrew G. , Heydari Bobak , Merchant Naeem , Bristow Michael , Fine Nowell , Gaztanaga Juan , White James A.
Published: March 2021

Background:

There is increasing evidence that right ventricular ejection fraction (RVEF) may provide incremental value to left ventricular (LV) ejection fraction for the prediction of major adverse cardiovascular events. To date, generalizable utility for RVEF quantification in patients with cardiovascular disease has not been established. Using a large prospective clinical outcomes registry, we investigated the prognostic value of RVEF for the prediction of major adverse cardiovascular events- and heart failure-related outcomes.

Methods:

Seven thousand one hundred thirty-one consecutive patients with known or suspected cardiovascular disease undergoing cardiovascular magnetic resonance imaging were prospectively enrolled. Multichamber volumetric quantification was performed by standardized operational procedures. Patients were followed for the primary composite outcome of all-cause death, survived cardiac arrest, admission for heart failure, need for transplantation or LV assist device, acute coronary syndrome, need for revascularization, stroke, or transient ischemic attack. A secondary, heart failure focused outcome of heart failure admission, need for transplantation/LV assist device or death was also studied.

Results:

Mean age was 54±15 years. The mean LV ejection fraction was 55±14% (range 6%–90%) with a mean RVEF of 54±10% (range 9%–87%). At a median follow-up of 908 days, 870 (12%) patients experienced the primary composite outcome and 524 (7%) the secondary outcome. Each 10% drop in RVEF was associated with a 1.3-fold increased risk of the primary outcome (
P
<0.001) and 1.5-fold increased risk of the secondary outcome (
P
<0.001). RVEF was an independent predictor following comprehensive covariate adjustment, inclusive of LV ejection fraction. Patients with an RVEF<40% experienced a 3.1-fold risk of the primary outcome (
P
<0.001) with a 1-year cumulative event rate of 22% versus 7% above this cutoff.

Conclusions:

RVEF is a powerful and independent predictor of major adverse cardiac events with broad generalizability across patients with known or suspected cardiovascular disease. These findings support migration towards biventricular phenotyping for the classification of risk in clinical practice.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04367220.
Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging Predicts Vein Wall Scarring and Statin Benefit in Murine Venous Thrombosis
Authors: Kessinger Chase W. , Qi Guanming , Hassan Malek Z.O. , Henke Peter K. , Tawakol Ahmed , Jaffer Farouc A.
Published: March 2021

Background:

The postthrombotic syndrome is a common, often morbid sequela of venous thrombosis (VT) that arises from thrombus persistence and inflammatory scarring of juxtaposed vein walls and valves. Noninvasive
18
F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging can measure neutrophil inflammation in VT. Here, we hypothesized (1) early fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) VT inflammation can predict subsequent vein wall scarring (VWS) and (2) statin therapy can reduce FDG-PET VT inflammation and subsequent VWS.

Methods:

C57BL/6J mice (n=75) underwent induction of stasis-induced VT of the inferior vena cava or jugular vein. Inferior vena cava VT mice (n=44) were randomized to daily oral rosuvastatin 5 mg/kg or saline starting at day −1. Subgroups of mice then underwent FDG-PET/CT 2 days after VT induction. On day 14, a subset of mice was euthanized, and VWS was assessed via histology. In vitro studies were further performed on bone marrow-derived neutrophils.

Results:

Statin therapy reduced early day 2 FDG-PET VT inflammation, thrombus neutrophil influx, and plasma IL (interleukin)-6 levels. At day 14, statin therapy reduced VWS but did not affect day 2 thrombus mass, cholesterol, or white blood counts, nor reduce day 2 glucose transporter 1 or myeloperoxidase expression in thrombus or in isolated neutrophils. In survival studies, the day 2 FDG-PET VT inflammation signal as measured by mean and maximum standardized uptake values predicted the extent of day 14 VWS (area under the receiver operating characteristic curve =0.82) with a strong correlation coefficient (
r
) of
r
=0.73 and
r
=0.74, respectively. Mediation analyses revealed that 40% of the statin-induced VWS reduction was mediated by reductions in VT inflammation as quantified by FDG-PET.

Conclusions:

Early noninvasive FDG-PET/CT imaging of VT inflammation predicts the magnitude of subsequent VWS and may provide a new translatable approach to identify individuals at risk for postthrombotic syndrome and to assess anti-inflammatory postthrombotic syndrome therapies, such as statins.
Does the intrusion of an avian nest predator elicit a change in the behaviour of a canopy-nesting passerine?
Authors: Sharp Alexander R. , Islam Kamal
Published: March 2021

Many studies have shown that nest predators affect their prey indirectly by inducing changes in the behaviour of the prey. Studies suggest that the type and degree of nest defence strategies depends heavily on species, along with nest type and location. One such strategy, nest vigilance, allows individuals to collect information and make informed decisions based on their surroundings. In this study, we simulated the intrusion of a common avian nest predator (blue jay, Cyanocitta cristata) into the territory of nesting cerulean warblers (Setophaga cerulea) and evaluated eight different behavioural variables to determine their response to the nest predator. Female cerulean warblers were more vigilant on their nest when exposed to a potential predator compared to a nest with lower threat of predation. Females exposed to a nest predator increased incubation bout by 109% and brooding bout by 60%. Our data also suggest that male cerulean warblers reduce their provisioning rate during the early nestling stage (−1 feeding/hour) and late nestling stage (−3 feedings/hour), although more data are needed. Modification of incubation bout length and nestling provisioning rate are common strategies employed by songbirds to reduce activity around the nest, by decreasing detection opportunities of visually-oriented nest predators. Currently, the only understanding we have on how cerulean warblers respond to a nest predator is based on observational data. The results of this study provide the first evidence that cerulean warblers are able to identify species that pose a threat to the safety of their nest, and that they modify their behaviour to reduce nest detection by predators. The results of this study provide a better understanding of a relatively unknown aspect of the breeding behaviour of this species. This study is also first to describe how an open-cup, canopy-nesting species responds to an increase in nest predation threat.
Does anthropogenic noise promotes advertisement call adjustments in the rubí poison frog Andinobates bombetes?
Authors: Jiménez-Vargas Gina Marcela , Vargas-Salinas Fernando
Published: March 2021

Anthropogenic noise, characterized by higher intensities at low frequencies, can restrict acoustic communication between conspecifics and eventually reduce the fitness of populations. We analysed changes in the call features of 52 males of the poison frog A. bombetes subjected to anthropogenic noise through playback experiments. Thirty-one males did not call during playbacks, but the remaining 21 males did. Fourteen of those 21 males increased their dominant call frequency on average 130.76 Hz when exposed to noise. Males did not increase or diminish the emission rate, number of pulses, and duration of their calls. It is possible that males by increasing the frequency of their calls are showing a behavioural strategy that maintain signal-to-noise ratio, which allows them to communicate acoustically in noisy habitats. Further studies are necessary to corroborate this hypothesis given that the magnitude of the increase in call frequency was small (<100 Hz) for most males.
Taxonomic notes on the genus Gynochthodes Blume (Rubiaceae) from Thailand
Authors: CHANTARANOTHAI PRANOM
Published: March 2021

Gynochthodes betongensis, a new species from Thailand, is described and illustrated. Gynochthodes cinnamomoea (syn. Morinda cinnamomea) is placed in the synonymy of G. villosa. Gynochthodes hispida is newly recorded for Thailand. Lectotypes are designated for G. puberula and M. cinnamomea. A key to the Thai species is also presented.
Notes on the subspecies of Plagionotus arcuatus (Linnaeus, 1758) with description of a new subspecies from Iran (Coleoptera: Cerambycidae)
Authors: KRÓLIK ROMAN , KRUSZELNICKI LECH , LASOŃ ANDRZEJ , WALCZAK MARCIN
Published: March 2021

This paper reviews the lower-ranked taxa within the species Plagionotus arcuatus (Linnaeus, 1758) and describes a new subspecies P. arcuatus shirazensis based on specimens from Iran. Some comments are made on the morphology of the subspecies, and a key, together with an exhaustive photographic documentation, is provided for their identification. The distribution ranges of these various taxa are discussed and basic biological information on all the subspecies is given. We explain our opposition to the subspecies Plagionotus arcuatus tastani Özdikmen, Atak & Uçkan, 2017, and have accordingly synonymized it with the nominative subspecies.
Klimaszewskia, a new genus of the tribe Tyrini from the Oriental region (Coleoptera: Staphylinidae: Pselaphinae)
Authors: YIN ZI-WEI , ZHANG WEN-XUAN
Published: March 2021

A new genus and species of the pselaphine tribe Tyrini, Klimaszewskia punctata gen. et sp. nov., is described and illustrated from Java, Indonesia. Klimaszewskia gen. nov. differs from all other genera of Tyrini primarily by the long, extended maxillary palpus having the fourth palpomere that is mesally expanded near the base, and has an elongate and narrowed apical region, combined with the presence of an antebasal sulcus of the pronotum, and the long first visible tergite. A single female with much larger body size from Nepal, representing a second species of the new genus, is briefly characterized but left unnamed.
Inflammatory Indicators and Hematological Indices in Contrast-Induced Nephropathy Among Patients Receiving Coronary Intervention: A Systematic Review and Meta-Analysis
Authors: Wu Xiaoyan , Ma Chao , Sun Daqing , Zhang Guojing , Wang Jinmiao , Zhang Enyuan
Published: March 2021

Strong inflammatory indicators such as C-reactive protein (CRP), high-sensitivity CRP (hsCRP), and hematological indices, including platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), hematocrit (HCT), and red blood cell distribution width (RDW), may be related with contrast-induced nephropathy (CIN). Our meta-analysis aimed at exploring the relationship between these indicators and CIN incidence among patients undergoing coronary intervention. Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and Science Direct from their inception to June 3, 2020. Meta-analysis was performed on pooled eligible studies. Finally, 26 studies involving 29 454 patients were included. Pooled analysis revealed that patients with higher CRP (odds ratio [OR] = 1.06, 95% CI: 1.01-1.12, P = .02), hsCRP (OR = 1.03, 95% CI: 1.01-1.06, P = .004), NLR (OR = 1.11, 95% CI: 1.01-1.20, P = .02), RDW (OR = 1.35, 95% CI: 1.19-1.53, P < .001), and lower HCT (OR = 0.94, 95% CI: 0.92-0.97, P = .003) all exhibited significantly higher CIN rates, but there was no significant association between PLR and CIN risk (OR = 1.12, 95% CI: 0.99-1.26, P = .07). Pre-angiography CRP/hsCRP and some hematological indices are associated with CIN.
Impact of Baseline Neutrophil-to-Lymphocyte Ratio on Long-Term Prognosis in Patients With Atrial Fibrillation
Authors: Wu Shuang , Yang Yan-min , Zhu Jun , Ren Jia-meng , Wang Juan , Zhang Han , Shao Xing-hui
Published: March 2021

We performed a retrospective analysis involving 1269 patients with atrial fibrillation (AF) to evaluate the predictive value of the neutrophil-to-lymphocyte ratio (NLR) on long-term outcomes. The primary outcomes were all-cause mortality and combined end point events (CEEs). Cox proportional hazards regression analysis and net reclassification improvement (NRI) analysis were performed. During a median follow-up of 3.32 years, 285 deaths and 376 CEEs occurred. With the elevation of the NLR, the incidence of all-cause mortality (2.77, 4.14, 6.12, and 12.18/100 person-years) and CEEs (4.19, 7.40, 8.03, and 15.22/100 person-years) significantly increased. Multivariate Cox analysis indicated that the highest NLR quartile was independently associated with the incidence of all-cause mortality (hazard ratio [HR] = 1.77, 95% CI: 1.19-2.65) and CEEs (HR = 1.66, 95% CI: 1.18-2.33). When the NLR was analyzed as a continuous variable, a 1-unit increment in log NLR was related to 134% increased risk of all-cause mortality and 119% increased risk of CEEs. Net reclassification improvement analysis revealed that NLR significantly improved risk stratification for all-cause death and CEEs by 15.0% and 9.6%, respectively. Neutrophil-to-lymphocyte ratio could be an independent predictor of long-term outcomes in patients with AF.
Clinical Outcomes in Chronic Total Occlusion Revascularization Versus No Chronic Total Occlusion Revascularization: Variability by Target Vessel
Authors: Lin Shen , Chen Sipeng , Yan Hongbing , Dou Kefei , Zhao Yan , Liu Jian , Zheng Zhe ,   On Behalf of the Beijing Coronary Angiography Registry Collaborative Group
Published: March 2021

We aimed to investigate the impact of target vessel on clinical outcomes in chronic total occlusion (CTO) revascularization versus no CTO revascularization. This multicenter, retrospective, cohort study involves patients with ≥1 CTO. After classification based on different CTO target vessels or multiple CTOs, patients were further categorized as the CTO revascularization group and the no CTO revascularization group based on treatment received. The primary outcome was a composite of death, myocardial infarction, stroke, repeated revascularization, and hospital admission due to ischemic symptoms. From August 2016 to August 2017, 1712 eligible patients were consecutively enrolled. Chronic total occlusion revascularization was associated with lower risk of 1-year major adverse cardiovascular and cerebrovascular events (MACCEs; adjusted hazard ratio [HR]: 0.36; 95% CI: 0.20-0.67; P = .001) compared with no CTO revascularization in left anterior descending (LAD) CTO patients. The benefit of CTO revascularization was not evident among those with left circumflex (LCX; adjusted HR: 0.51; 95% CI: 0.23-1.10; P = .087), right coronary artery (RCA; adjusted HR: 1.17; 95% CI: 0.59-2.33; P = .648), and multiple CTOs (adjusted HR: 1.00; 95% CI: 0.41-2.44; P = .994). Revascularization for LAD CTO, but not LCX, RCA, or multiple CTOs, was associated with lower risk of 1-year MACCEs compared with no CTO revascularization.