bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Factors Associated with Probable Sleep Bruxism of Children and Teenagers with Cerebral Palsy
Authors: da Silva TAE , Silva AM , Alvarenga ESL , Nogueira BR , Prado RR , Mendes RF
Published: November 2020

Aim: To assess the association between probable sleep bruxism (PSB) and other occlusal characteristics in children and teenagers with Cerebral Palsy (CP). Study design: A cross-sectional study was carried out with 148 participants (74 with CP and 74 without special needs) aged between 2 and 14 years old. Participants underwent an oral clinical examination to evaluate the occlusal characteristics. Parents/caregivers filled out a questionnaire with information related to the typical sounds of PSB, sociodemographic factors and the presence of harmful oral habits in the study participants. Data analysis was carried out, using Chi-square or Fisher’s exact test and Odds Ratio (p<0.05).Results: PSB and malocclusion (68.9% and 95.9%, respectively) were more prevalent in participants with CP than in participants without CP. The association between PSB and the presence of a wear facet was statistically significant (p < 0.001) in participants with CP. In this group, 64.8% of participants with PSB presented tooth wear. Conclusion: Presence of dental wear facets was significantly associated with PSB in individuals with cerebral palsy.
O núcleo central da representação social de estagiários(as) do curso de Pedagogia/UERN acerca da docência
Authors: Vieira Antônia Maíra Emelly Cabral da Silva , Melo Elda Silva Do Nascimento
Published: November 2020

This study is part of the master’s dissertation entitled “The social representation of interns of the Education course about teaching” presented to the postgraduate program in Education of the Federal University of Rio Grande do Norte (UFRN). The research seeks to identify the social representation of interns of the Education course at UERN about teaching. We present the results of the evaluation of the TALP (Free Word Association Technique), analyzed in the light of the Theory of Social Representations (MOSCOVICI, 1978) and the Central Nucleus Theory (ABRIC, 1998) with the help of EVOC software and the technique of content analysis (BARDIN, 2011) that allowed us to visualize the central nucleus of the social representation of teaching. The results contemplate regularities that helped us to perceive that the subjects of the research construct a social representation of teaching, rooted in the central elements as: love, dedication, teaching and learning.
Produção de alface crespa, cv. Cristina no semiárido brasileiro com sistema de irrigação subsuperficial de baixo custo
Authors: Lins Cassimiro Carlos Alberto , Oliveira filho Francisco De Sales , Feitosa Selma Dos Santos , Pereira Junior Ednaldo Barbosa , Siqueira Eliezer Da Cunha , Dos Santos Pedro Alves
Published: November 2020

The Brazilian semiarid has severe climatic conditions including low rainfall rates which constraints agricultural activities in the region. In order to reduce the difficulties of producers in the cultivation of curly lettuce, specifically regarding the efficient use of water, in this study we evaluate the use of social technology “water saving garden” on the effect of different irrigation water depths on the lettuce productivity. The experiment was carried out in a greenhouse at the Federal Institute of Paraíba, in 2018, using a randomized block design, with five treatments and four repetitions. Each treatment consisted of five irrigation depth, corresponding to 25%, 50%, 75%, 100% and 125% ETo (reference evapotranspiration). The results demonstrated that the number of leaves and the dry matter of the aerial part showed quadratic response to the treatments, with maximum values ranging 75% to 99% ETo. The maximum productivity (32.570 kg ha-1) was obtained with the application of the 224.27 mm of irrigation depth; the greatest efficiency in the use of water (269,25 kg ha1 mm1) occurred with 56.88 mm irrigation water depth, corresponding to 25% of ETo.
The optimization of automated goods dynamic allocation and warehousing model
Authors:   Sichuan College of Architectural Technology, Hou Z.K.
Published: November 2020

In the development of modern logistics, the role of automated cargo warehousing is gradually reflected, which is essential for the automatic distribution of goods. This paper briefly introduced the automatic location allocation model and the particle swarm optimization (PSO) algorithm used to optimize the model. At the same time, it introduced the concept of genetic operator and multi-group co-evolution to improve the algorithm, and then the simulation analysis of standard PSO and improved PSO was performed on MATLAB software. The results showed that the improved PSO iterated fewer times and get better solution sets; compared with the manual allocation scheme, the improved PSO calculation reduced more warehousing time, lowered more center of gravity height, and improved shelf stability. In summary, the improved PSO algorithm can effectively optimize the automated goods dynamic allocation and warehousing model.
The Experience Qualities Approach to Leadership and Employee Well-being
Authors: Salmi Ilkka , Pietiläinen Ville , Syväjärvi Antti
Published: November 2020

A phenomenological psychology approach in organizational studies has been somewhat overlooked, particularly in research on leadership and employee well-being. This study presents a new way of examining leadership and employee well-being. A novel experience qualities approach was utilized with the aim of revealing the authentic structure of human experiences, particularly experience qualities such as emotions, knowledge, and assumptions. This study investigated the role of leadership in creating employee well-being experiences in a professional organization. The data were collected from 23 in-depth interviews conducted with company leaders and employees in Finland and then analyzed using the phenomenological method. The results indicated affirmative similarities and differences (experience domains) in experience qualities of well-being between leaders and employees. By identifying different experience qualities of well-being, leaders can promote their own and employees’ well-being more precisely and effectively. Practical implications for leaders are discussed.
Youth Health and Safety Groups: Process Evaluation from an Intervention in Danish Supermarkets
Authors: Albertsen Karen , Grøn Sisse , Meyland Kristina Karstad , Limborg Hans Jørgen
Published: November 2020

Young workers employed in temporary positions constitute a vast part of the employees in the Danish retail sector. The aim of the present study was to evaluate the implementation of an intervention to establish H&S groups for young workers in Danish supermarkets. The intervention aimed to include and involve the young workers in the management of their work environment and work conditions, and simultaneously to strengthen the organization’s ability to include them in the H&S management. The study was designed as a multiple case study. Twelve youth H&S groups were established and ran for 2 months within 10 supermarkets. Results based on qualitative data suggest that H&S groups for young workers have potential for increasing inclusion and involvement in the work environment among the young workers and for being beneficial for the supermarkets. However, the implementation requires continuous support from the management and H&S representatives.
Critical view of the concept of sequence stratigraphy
Authors:   Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Beisel Alexander L.
Published: November 2020

Based on a theoretical analysis, the main shortcomings of modern varieties of the concept of sequence stratigraphy are shown: they do not comply with the definition of the relative sea level, which is given by the authors themselves; the nature of tectonic immersion, which cannot have a sinusoidal shape, is not taken into account; the boundaries of sequences, identified as subaerial disagreements on the periphery of the cover, are unlawfully compared with consonant boundaries within the basins. The need for a thorough review of this concept based on the new basic provisions is shown.
"Eastern transfer" as the main argument in favor of the water origin of the ridge relief of the South of Western Siberia
Authors:   Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Beisel Alexander L. , Sobolev Evgeny S. ,   Trofimuk Institute of Petroleum Geology and Geophysics SB RAS
Published: November 2020

New data were obtained in favor of “Eastern transfer” – the transfer of material from the North-East to the South-West during the formation of the ridge system in Late Pleistocene. They consist in two positions: first, they are longitudinal furrows in the axial part of the ridges, which are fan-shaped split at their South-Western ends; second, the inextricable genetic link of the ridge relief with the spillways is confirmed. The Eastern transfer is interpreted as convincing evidence of the water origin of the ridge relief.
Preliminary data on dinocysts of the upper toarcian – lower aalenian of Northeastern Siberia
Authors:   Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Goryacheva Anna A.
Published: November 2020

The article presents preliminary results of palynological studies of the Lower-Middle Jurassic deposits, uncovered by the natural exposure of 7A on the Kelimyar river and represented by the Kelimyar Formation. The Toarian biostraton with Valvaeodinium aquilonium is identified in the section. As a result of studies in the Lower Aalenian samples, only rare dinocysts taxa were identified that did not allow to divide the upper part of the section on this group of unicellular algae.
History of tectonic development and quantitative assessment of source rock generation power in the tolon field (Sakha Yakutia)
Authors:   Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Kosmacheva Alina Yu. , Semenov Sergey S. ,   Novosibirsk National Research State University, Fedorovich Marina O. ,   Trofimuk Institute of Petroleum Geology and Geophysics SB RAS
Published: November 2020

The paper is aimed at the geoseismic interpretation, picking principal reflection horizons, structure and isopach map generation. The maps, seismic- and paleosections are an integral part not only of the structure-and-tectonic description, but also history analysis of the Tolon field. The research identifies gas-window-entry time of the Permian source rock, initial development and power of intense gas generation, present-day generation points in the source rocks. Funding: The reported study was funded by RFBR, project number 19-35-90039.
The Equitable and Prospering Utilization of Former HGU (Right of Exploitation) Land for Indonesian Farmers
Authors: Winanti Atik , Sinja M. r Arafah , Nugroho Andriyanto Adhi
Published: November 2020

The right of exploitation (HGU) case in Rangkas Bitung district, Lebak Regency can indeed be classified as a light agrarian conflict category. This cannot be separated from the conflict dynamics involving various parties with varied interests. The reclaiming and compensation cases with Rangkasbitung people constitute other clear facts which show that not only this HGU only presents ecological facts, but it also indicates socially-constructed landscape to meet a function as an area of living, a place to grow the collective identity of a community group and to develop the community culture.
Implementing Religious Characters of Early Children in the Pandemic Time of Covid 19
Authors: Lestari Dwi Puji , Yufiarti Yufiarti , Supena Asep
Published: November 2020

The purpose of this study is to provide insight into the implementation of religious character planting in early childhood in the family during the COVID-19 pandemic. The study involved 10 parents. The results of research on the COVID-19 pandemic make families spend more time with children. There are four aspects of religious character instilled in the family namely beliefs, practices, attitudes, and knowledge. In implementing religious characters there are several methods that parents use to embed every aspect of a religious character. Methods of lectures and storytelling to instill aspects of beliefs, methods of lectures, and direct practice in aspects of attitude and practice. Methods of storytelling and dialogue in instilling religious character knowledge in early childhood.
Women and Media as a tool to Attract Online News Readers in Indonesia
Authors: Soleh Mohammad , Astuti Nurhaeni Ismi Dwi , Hastjarjo Sri
Published: November 2020

The rapid development of technology effects changes in the delivery of news information from printed media to online media. This positive change was not followed by the changes in media perceptions towards gender. In online media such as indosport.com, there are still many women as news objects by presenting them in quite interesting photos and videos as well as making tantalizing titles. This research aims to find out how women's representations are shown on the news on Indosport.com. How is the reader's position on the news, and who become the subject and object of the news on indosport.com. The research data comes from news on the online news portal indosport.com for the period November 2019 to March 2020. The data analysis technique in this study uses critical discourse analysis from Sara Mills. The results shows that women are shown on the news in a bad position. They are often shown in interesting photos and videos in order to become a magnet for readers. News writers and netizens play a role as subjects in the news, while women become the objects in the news. The reader's position is directed according to the thoughts of the writer and netizens, namely men.Key words: critical discourse analysis; Sara Mills; online media; indosport.com
Functions of Communication Value of Agricultural Committee of Atoni Pah Meto Customs
Authors: Manafe Yermia Djefri , Neolaka Stevridan Yantus
Published: November 2020

Rituals have a function in people's lives that will last a long time and will not be easily lost, as it is said in the axioms of functional theory that everything that has a function will not easily disappear by itself, because it has always existed, has a function, and even plays a role. a number of functions. With regard to the values and functions of rituals, their existence can be understood integrally with the context of the existence of the supporting communities. The indigenous peoples (Atoni Pah Meto) are part of the ethnic Timorese who currently persist with ritual activities in their agricultural activities. The purpose of this study was to determine the value and function of rituals in the agricultural activities of indigenous peoples (Atoni Pah Meto). This research method uses a qualitative tradition related to the rituals carried out by dryland agricultural communities in the lives of indigenous peoples (Atoni Pah Meto). The results of this study indicate that value is something that is very high which is able to direct the lives of indigenous peoples (Atoni Pah Meto) in their daily social life. The values in question are values: religious, unity, ecological, social anthropological, socioeconomic, and socio-political.
Implementation of Good Corporate Governance Principles in Commercial Banks
Authors: Gani Adinda Mutia , Kurniawan Kurniawan , Hirsanuddin Hirsanuddin
Published: November 2020

This research was conducted to find out how the application of the principles of Good Corporate Governance by Bank Indonesia to Commercial Banks and what are the legal consequences if Commercial Banks do not apply the principles of Good Corporate Governance in carrying out banking activities. This research is a normative legal research with a statutory and conceptual approach and qualitative data analysis. The results obtained from research conducted were that the implementation of Good Corporate Governance at Commercial Banks by Bank Indonesia was caused by the economic and monetary crises that occurred in Indonesia in 1997-1999 due to the failure to apply Good Corporate Governance in every activity in the company and in banking and legal consequences. for Commercial Banks that do not apply Good Corporate Governance in their banking activities as stipulated in Bank Indonesia Regulation Number 8/14 / PBI / 2006 Article 69, namely administrative sanctions and No criminal sanctions for Commercial Banks that do not apply Good Corporate Governance in their banking activities.
How Entrepreneurship Can Be Learned through Experiential Learning Formats, Especially through Training Firms
Authors: Heinze Anne
Published: November 2020

A look at entrepreneurship education research shows that there are basically two types of entrepreneurship courses: First, courses for entrepreneurship and second, courses about entrepreneurship such as lectures, formal seminars, individual essays etc. Most of the latter courses can be characterized as teacher-centric where the student involvement is passive. From a more modern perspective and in order to train entrepreneurs trying, experimenting and learning about one's own experience is crucial. More innovative approaches, such as project-based learning, action-based learning and experiential learning, therefore, are gradually appearing on the scene In this context, within the last few years some universities have introduced training firms, mostly for students of economics and business. In Germany, due to a lack of legal possibilities training firms at public universities are still a rarity and therefore under-researched. Thus, the research question for the present contribution is how informal learning can be structured using training firms, and what effects this has on the preparation of learners for later professional practice and / or self-employment.

Therefore, the methodology for this paper is first to review the literature related to entrepreneurial learning in order to better understand the informal learning experience in training firms. Second, the case of a communication design agency for students around HTW Berlin, a public university for applied sciences, is analyzed to gain insight into the impact that practice firms can have on entrepreneurship education in general, and in particular in non-business subjects. For this purpose, a case study has been developed based on interviews, which include both the perspective of the students and of the trainer. Overall, the results will show a best practice example of entrepreneurial training and learning in a university context, which can be useful for those involved in the development of course concepts for entrepreneurship education.
The impact of COVID-19 Crisis on the Global Economy and the North American Hegemonic Cycle: A reading
Authors: Carvalho Patrícia Nasser de , Senhoras Elói Martins
Published: November 2020

Based on the theorical framework that considers contextual and structural long-term perspectives of world hegemonic cycles and transitions of global powers, the aim of this reading is to critically analyze the ongoing and potential impact of the pandemic in the light of a conjunctural and historical perspective. The hypothesis is that although the COVID-19 crisis has already had deep negative impact on the global economy and represents a perfect storm for the US hegemony, seeing as the country is being challenged by many factors with strong magnitude and adverse effects, indeed it would not generate an immediate terminal crisis of the North American hegemony. Just in the long run the COVID-19 pandemic has the potential to trigger another world hegemonic power. The reading is based on the theoretical perspectives of world hegemonic cycles in international relations and is methodologically characterized as an explanatory and descriptive study and is built on a bibliographic review for the collection of theoretical and historical data.
Hypertensive crisis: modern view of the problem and optimization of diagnostic and therapeutic modalities
Authors: Kryukov E. V. , Potekhin Nikolay P. , Fursov A. N. , Chernetsov V. A. , Chernov S. A. , Zakharova E. G.
Published: November 2020

The data collected by Burdenko Military Hospital indicate that in the 1980s hypertensive crisis (HC) occurred in roughly 30% of the patients with AH. This value fell down to 16% by 2012, with a rise in the number of uncomplicated crises from 46 to 62%. Analysis of the causes behind these changes showed that half of the patients simply experienced an elevated arterial pressure with minimal clinical symptoms. The decrease in the number of complicated cases from 54 to 39% is doubtful bearing in mind that ICD-10 gives the status of nosological entities to complications of hypertensive crisis (stroke, myocardial infarction, etc.) but not to the HC syndrome proper requiring urgent hospitalization; due to this hypertensive crisis itself tends to be disregarded and not included in statistics. HC with acute clinically significant lesions of target organs requires intensive care or resuscitation using infusion of vasodilators and loop diuretics to stabilize arterial pressure. In case of uncomplicted HC and aggravation of hypertensive disease, the medications of choice are oral short-acting ACE inhibitors and imidazoline receptor agonists.
Anemic syndrome in patients with community-acquired pneumonia
Authors: Budnevsky A. V. , Esaulenko I. E. , Ovsyannikov Evgeniy S. , Labzhaniya N. B. , Voronina E. V. , Chernov A. V.
Published: November 2020

Community-acquired pneumonia remains a most widespread acute infectious disease of socio-economic significance all over the world. Up to 30% of the patients present with anemia responsible for the unfavourable prognosis and elevated mortality. Not infrequently, anemia is not diagnosed during the hospital stay und therefore remains uncorrected. Severe anemia results in enhanced hypercapnia and slowed maturation of red blood cells in the bone marrow which facilitates the development of ischemic syndrome. Hepcidin, a mediator of inflammation and iron-regulatory hormone, plays an important role in the clinical course of community-acquired pneumonia. Hepsidin production increases during inflammation; it suppresses erythtropoiesis and depletes the iron depot leading to so-called anemia of inflammation. Hypoxia and anemia activate erythtropoiesis, and the released erythropoietin inhibits hepsidin production. During pneumonia resolution, hepsidin promotes recovery from anemia by activating iron absorption. The current literature contains few data on the use of hepcidin as a diagnostic marker of anemia. The necessity of treating anemia in patients with pneumonia under hospital conditions is a matter of discussion. Direct involvement of hepcidin in iron metabolism creates a prerequisite for the treatment of anemia. Medicamental suppression of its activity by stimulating erythtropoiesis can facilitate normalization of iron metabolism and restoration of hemoglobin level.
A rare combination of systemic scleroderma, sarcoidosis and psoriasis at advanced age
Authors: Pak Yuliya V. , Men’shikova I. V. , Chernyak V. I. , Yugai A. S.
Published: November 2020

We report a rare combination of systemic sclerosis, sarcoidosis, psoriatic arthritis and diverticulosis with severe complications in a 41-year-old male who has been treated by a rheumatologist since 10 years of age.
Debatable aspects of pathogenesis and diagnostics of irritable bowel syndrome (IBS) and inflammatory bowel diseases with IBS-like diseases
Authors: Pogromov A. P. , Tashchyan Ol’ga, V. , Mnatsakanyan M. G. , Dyukova G. M.
Published: November 2020

Aim of review: To analyze current publications devoted to controversial issues of pathogenesis, diagnosis and differential diagnosis of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) in remission with IBS-like symptoms. Key points: There are three main hypotheses discussed in the literature: 1) IBS as a prodrome, pre-stage of the IBD; 2) IBS and IBD are different variants of inflammatory disorder which is common to both diseases; 3) The onset of IBS-like symptoms in IBD patients in remission. Conclusion: It is shown that modern literature data on this issue is contradictory and ambiguous.
Why is capsule endoscopy needed?
Authors: Rapoport S. I. , Rasulov Magomed I.
Published: November 2020

The article discusses the development of videocapsule endoscopy and related problems, the ways to improve the method, and its social significance.
Peculiarities of humoral immunity against Epstein-Barr virus and Helicobacter pylori of gastric mucosa in patients with stomach dysplasia and cancer
Authors: Vusik Marina V. , Pleshko R. I. , Avdeenko T. V. , Cheremisina O. V. , Matveenko O. A.
Published: November 2020

High prevalence of infection with Epstein-Barr virus (EBV) andpotentially oncogenic Helicobacter pylori requires understanding their role in pre-cancerous and cancerous processes. We studied peculiarities of humoral immunity against Epstein-Barr virus and the severity of viral infestation in patients with stomach dysplasia, cancer and concomitant infection of gastric mucosa with H.pylori. It was shown that the development of dysplastic changes in the infected mucosa is most frequently associated with high titers of IgG and IgA to capsid antigen and early EBV antigens which suggests their cooperation in the development ofprecancerous disorders. The character of antiviral humoral reactions in cancer patients depends on viral infestation of the neoplastic tissue. ECB and H.pylori infections are mutually exclusive in such patients. The absence of H.pylori is associated with the high level of antiviral humoral reactions and high infestation of the neoplastic tissue with EBV whereas low levels of antiviral humoral reactions occur in patients with H.pylori infection.
Non-invasive methods for diagnostics of liver fibrosis in patients with autoimmune hepatitis and autoimmune hepatitis - primary biliary cirrhosis
Authors: Sheptulina Anna F. , Shirokova E. N. , Ivashkin V. T.
Published: November 2020

Aim: to evaluate the performance of non-invasive indices for the diagnosis of pronounced fibrosis and cirrhosis in patients with autoimmune hepatitis (AIH) and autoimmune hepatitis - primary biliary cirrhosis variant (AIH-PBC). Methods: Data from 70 patients with AIH and 53 patients with AIH-PBC were analyzed retrospectively. Fibrosis-4 score (FIB-4), aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), AST to platelet ratio (APRI) and platelet count to spleen diameter ratio (PLT/SPD) were calculated based on results of blood analyses and abdominal ultrasound. Results of the histological study of the liver with the assessment of the stage of fibrosis (according to the METAVIR score) were obtained for all patients. The diagnostic accuracy of the tests was evaluated based on the area under the receiver operating characteristic curve (AUROC). Results: 51 (72.8%) of the 70 AIH patients (median age [25th - 75th interquartile range] 41 years [27-51]) had markedfibrosis (≥F2) and 28 (40%) presented with cirrhosis. In the PBC-AIHgroup (n=53; median age 50years [43.5- 57]) 42 (79.2%) and 21 (39.6%) patients had marked fibrosis (≥F2) and cirrhosis (F4), respectively. PLT/SPD was superior to other indices studied for the discrimination between mild and severe fibrosis (≥F2) as well as between severe fibrosis and cirrhosis (F4) in AIH (AUROCs: 0.840 [95% confidence interval (CI) 0.744-0.935] and 0.968 [0.934-1.000], respectively) and AIH-PBC (AUROCs: 0.752 [0.584-0.919] and 0.889 [0.800-0.979], respectively). Conclusion: The accuracy of the PLT/SPD index for diagnostics of ≥F2 is 79.1% and 76.9% and for diagnostics of F4 85.1% and 82.7% in AIH and AIH-PBC patients respectively.
Pulmonary hypertension in patients with systemic scleroderma
Authors: Karoli N. A. , Rebrov Andrei P.
Published: November 2020

Aim. To evaluate the frequency of pulmonary hypertension (PH) in patients with systemic scleroderma (SSD) and elucidate clinical features of SSD with and without concomitant PH. Materials and methods. The study included 206 patients (189 women and 17 men) with SSD treated in Rheumatological Department, Saratov Regional Hospital. Clinical features, results of echocardiography and external respiration function (ERF) studies were analyzed in SSD patients with and without concomitant PH. Results. PH was documented in 33% of the patients. Their clinical condition, changes in left and right hear as well as ERF were elucidated. Conclusion. The study confirmed the high informative value of echocardiography used to evaluate ERF in patients with SSD and the possibility to apply this method for screening PH in SSD patients. The risk factors of PH in SSD patients include advanced age, apnoea, disturbed ERF, and sclerodactylia.
Cardiogenic shock: can the well-forgotten old become the new?
Authors: Lithovskiy Igor A. , Gordienko A. V.
Published: November 2020

Cardiogenic shock (CS) is considered to be the most severe variant of acute heart failure. It occurs against the background of myocardial infarction or non-coronary myocardial disease with the loss of 40-50% contractile ability by the left ventricular mass and acute heart overload of another genesis. The marked decrease of blood pressure is accompanied by generalized impairment of microcirculation in all organs. The acting recommendations for emergency assistance suggest to recover blood perfusion pressure in ischemic tissues by inotropic drugs vasopressors, crystalloids that eliminate hypovolemia. However, the recovery of hemodynamic parameters using these medicines is accompanied by increased load on the myocardium and causes only a slight temporary increase of blood pressure. Death rapidly occurs in almost 100% of cases because offast heart energy depletion There is no doubt that stable recovery of hemodynamic in CS is not possible without sustainable recovery of myocardial contractility. The effective discharge of myocardium by drugs should not be accompanied by deterioration of blood supply to peripheral organs. Taking into account the literature data and pharmacological properties of different groups of drugs, there is every reason to believe that nitroglycerin may be the drug of choice for the treatment of cardiogenic shock. It reduces myocardium preload without impairment of microcirculation in the peripheral organs. This conclusion is preliminary and requires verification in randomized trials.
Skin markers of diabetes mellitus
Authors: Lykova Sofya G. , Nemchaninova O. B. , Pozdnyakova O. N. , Reshetnikova T. B. , Spitsyna A. V. , Makhnovets E. N. , Petrenko O. S.
Published: November 2020

Over the past decade, considerable material on dermatoses accompanied by carbohydrate, lipid and the other types of metabolic disorders has been accumulated. The review provides information on dermatoses encountered in this group of patients; the clinical manifestations are discussed as well as the treatment options. Both frequent dermatoses (diabetic dermopathy, necrobiosis lipoidica, candidiasis and mycoses pedis, acanthosis nigricans) and rarely diagnosed ones (acquired perforating dermatosis, diabetic blisters) are considered. The emphasis is laid on dermatoses suggesting carbohydrate metabolism disorders.
Dynamics of characteristics of cerebral circulation during combined treatment with amlodipine and bisoprolol
Authors: Zapesochnaya Irina L. , Avtandilov A. G.
Published: November 2020

Objective: to assess dynamics of cerebral blood flow when starting combined therapy with amlodipine and bisoprolol in hypertensive patients working in the Far North under various labor schedules. Material and methods. We studied 140 patients with grade 1-2 hypertension divided into two groups depending on their work schedule. Group 1 (n=72) included subjects working only at daytime; group 2 (n=68) consisted of subjects working in shifts. All patients received combined therapy with amlodipine and bisoprolol. The final mean daily dose of amlodipine/bisoprolol amounted to 8,3±1,3/9,8±1,6 mg/day and 9,5±1,5/14,5±1,2 mg/day in groups 1 and 2 respectively. Doppler ultrasound of the common carotid, internal carotid and vertebral arteries (OCA, BCA and PA, respectively) was performed before, 12 weeks, and 6 months after onset of therapy. Results. At the end-point of intervention (6 months) patients of group 1 showed an increase in peak systolic velocity (Vps) in OCA, BCA and PA (by 4,1, 5,9 and 5,5% respectively) and maximum end-diastolic flow velocity (Ved) in ОCA and ВCA (by 5,8 and 5,2% respectively). Patients of group 2 showed an increase of Vps in OCA, BCA and PA by 6,3, 8,4 and 7,1% respectively; Ved in OCA and BCA by 6,4 and 14,5% respectively. All patients exhibited a pronounced downward trend of the peripheral resistance index of in all studied arteries. The tendency to a decrease in the thickness of the intima-media complex was documented: by 4,1%, in group 1, 6,8% in group 2, without reaching the normal level. Conclusion. 6-month starting combined therapy with amlodipine and bisoprolol in hypertensive patients has positive effect on cerebral hemodynamics manifest as the increase in parameters of cerebral blood flow velocity and reduced peripheral resistance index. Pronounced downward trend in the thickness of the intima-media monitoring in both groups was apparent but without reaching the standard level.
Modem means for the treatment of atrial fibrillation in diabetic patients
Authors: Kucherenko O. D. , Brek V. V. , Shelest Boris A. , Kovaleva Yu. A.
Published: November 2020

The authors discuss modern approaches to the treatment of atrial fibrillation with reference to diabetic patients. The studies carried out thus far showed the importance of differential anti-arrhythmic therapy taking account of the clinical form of ciliary arrhythmia. The possibility of surgical and preventive treatment (up-stream therapy) is demonstrated.
Peculiarities of diagnostics and treatment of patients with recurrent myocardial infarction
Authors: Gazaryan Georgy A. , Taraseyeva Ya. V. , Gazaryan L. G. , Yevstratova S. G. , Makaova F. M. , Mazanov M. Kh. , Nefedova G. A. , Alidzhanova Kh. G. , Golikov A. P.
Published: November 2020

The aim of the study was to evaluate the efficiency of invasive strategies for the treatment of 306 patients with recurrent myocardial infarction (IM) admitted to our clinic in 2003-2007. We compared the results of three approaches: various forms of transdermal coronary interventions (TDI) including delayed (24-72 hr) ones (n=30), surgical myocardial revascularization within 8-12 weeks after the onset of recurrent myocardial infarction (n=25), and conservative therapy (n=251). Overall cardiovascular lethality was estimated during 5 years in 101 patients. It was shown that recurrent myocardial infarction is a predictor of high risk of death associated, in the absence of reperfusion therapy, with high intra-hospital and long-term lethality. TDI soon after recurrent IM does not exclude possibility of its application in a later period. Various interventions including delayed ones markedly decrease the frequency of complications and lethal outcome that remains high in their absence. At the same time, severe lesions of the coronary bed in many patients with recurrent MI limit the possibility of using TDI and should be regarded as indications for planned surgical myocardial revascularization. Coronary bypass surgery after myocardial scarring prevents progress of left ventricle dysfunction, improves its contractility and increases life expectancy. Enhanced availability of reperfusion strategies in the form of TDI and/or delayed surgical myocardial revascularization opens up new possibilities for effective treatment of recurrent MI.
Acute coronary syndrome without ST segment elevation: possibilities for predicting the clinical course at the posthospital (6 and 12 months) stage
Authors: Mikhailova Zinaida D. , Shalenkova M. A. , Klimkin P. F.
Published: November 2020

Aim. To measure blood IL-6, IL-10, creatinine levels, calcium, sodium and potassium in blood and saliva, melatonin in urine of patients with acute coronary syndrome without ST segment elevation for the prediction of the clinical course at the posthospital stage. Material and methods. The study included 93patients with complicated (n=46) and uncomplicated (n=47) coronary syndrome without ST segment elevation. Blood IL-6, IL-10, creatinine levels, calcium, sodium and potassium in blood and saliva, melatonin in urine were determined on days 1-3 after hospitalization. 6-hydroxymelatonin was measured by HPLC in urine collected between 23 p.m. and 8 a.m., melatonin i in urine collected between 8 a.m. and 23 p.m. Results. Complicated coronary syndrome was associated with increased levels of melatonin (night), blood IL-10 and Na, salivary Na and Ca while the uncomplicated condition with increased blood melatonin (daytime), IL-6, creatinine, Ca, Na, K, and salivary K. 90 patients were followed up within 12 months after discharge. End-points developed in 36 (40%) of Original investigations them. Logistic analysis yielded variables and 2 logistic regression equations The data on night melatonin +5 and +4 were included in ROC analysis. The night melatonin +5 values over 0.7453 were associated with increased risk of complications in the post-hospital period (6 months) and values of0.7453 or lower with the enhanced probability of uncomplicated clinical course. Prognostic sensitivity was estimated at 90%, specificity at -54.39%. The night melatonin +4 values over 0.2903 were associated with increased risk of complications in the post-hospital period (12 months) and values of 0.2903 or lower with the enhanced probability of uncomplicated clinical course. Prognostic sensitivity was estimated at 77.8%, specificity at -59.26%. Conclusion. The night melatonin +5 and +4 models can be used to predict the clinical course of acute coronary syndrome during 6 and 12 months of the post-hospitalization period.
Atherosclerosis of abdominal aorta in a population of the northern part of European Russia
Authors: Fedotova Elena V. , Popov V. A. , Malyavsky I. Yu. , Sementsov V. V.
Published: November 2020

Atherosclerosis is a major challenge for public health services throughout the world. It is a systemic degenerative disease affecting all arterial basins and most frequently occurring in men aged above 40 years. Multifocal lesions are much more typical than isolated lesion of a single basin. Atherosclerosis is a frequent cause of impaired patency of visceral branches of abdominal aorta and is a chronic disorder of visceral circulation manifest as ischemia of abdominal organs. We studied native preparations of abdominal aorta from residents of the northern part of European Russia using the WHO-recommended visual planimetric method. It was shown that 93.4% of the residents of this region aged above 50 years have abdominal aorta affected by atherosclerosis. Statistical analysis did not reveal significant differences between the frequency of atherosclerotic lesions in men and women. Most of them had raised aortic lesions. Correlation analysis with the calculation ofpairedPearson correlation coefficients demonstrated moderate correlation between atherosclerotic lesions of abdominal aorta and the stage of atheromatosis (r=0,42; p = 0,000).
Hepatic tuberculosis with the development of fibrosis and concomitant steatohepatitis
Authors: Esedov E. M. , Shakhnazarov A. M. , Abasova Albina S. , Medzhidova R. A. , Akhmedova F. D. , Muradova V. R. , Magomedeminova S. R.
Published: November 2020

Tuberculous lesions of the liver frequently occur in autopsy material, even though most of them are clinically unapparent. Pathogenetically, hepatic tuberculosis is a manifestation of general military tuberculosis with the infection brought in through the hematogenous route (through the hepatic artery or the portal system) as a result of intestinal or mesenteric lymph node tuberculosis. We report a case of combination of hepatic tuberculosis and diabetes mellitus in a young woman with reference to the clinical course of the disease, its diagnostics and treatment.
Clinical manifestations of antiphospholipid syndrome associated with lesions of the central nervous system
Authors: Budnevskiy A. V. , Kutashov V. A. , Kravchenko Andrey Ya.
Published: November 2020

Antiphospholipid syndrome (APS) is one of the important but poorly known conditions. Its symptoms are ofparticular interest for neurologists since thrombi are most often localized in the cerebral blood vessels which leads to ischemic cerebrovascular accidents (AICS). APS can also manifest itself in the following symptoms: epileptic attacks, dementia, headache, chorea, peripheral neuropathy, myelo- and encephalopathy phenomenologically similar to multiple sclerosis. This article presents a clinical case of secondary APS with the neurological manifestations in a 25-year-old female patient.
A rare case of oxalate nephropathy with acute renal injury
Authors: Ustinova E. E. , Malov V. I. , Lareva Ntal’ya V.
Published: November 2020

Objective: This case demonstrates the difficulty of diagnostics of oxalate nephropathy and possibility of development of acute kidney injury. Summary: The paper describes a patient with oxalate nephropathy and acute kidney injury. Specific features of oxalate diathesis are discussed as well as approaches to its diagnosis. Clinical peculiarities and diagnostic difficulties are described. Conclusions: Early diagnosis of oxalate nephropathy and treatment permits to improve prognosis.
Case report of a combination of periodic disease and irritable bowel syndrome
Authors: Pogromov A. P. , Mnatsakanyan Marina G. , Kolosova K. Yu.
Published: November 2020

The article reports a case of atypical picture of a combination ofperiodic disease and irritable bowel syndrome in a 52 year old patient.
The significance of calprotectin for the evaluation of activity of inflammation in ulcerative colitis
Authors: Nikitin A. V. , Matyukhin Anatoliy Andreevich , Mordasova V. I. , Latysheva M. N.
Published: November 2020

The combination of clinical and instrumental methods with non-invasive markers of ulcerative colitis allows to predict the incidence of this disease and optimize conditions and quality of medical care. To-day, the use of non-invasive markers is a topical issuesince itprovidesa most informative screening test for the high-accuracydetermination ofresidual faecal calprotectin.
Comparative assessment of the effectiveness of treatment of pulmonary thromboembolism in elderly patients
Authors: Medvedev A. P. , Deryabin R. A. , Nemirova S. V. , Pichugin V. V. , Bokarev Igor’ N.
Published: November 2020

We compared the efficiency of treatment of 99 patientswith pulmonary thromboembolism using thrombolytic agents, surgical intervention, and anticoagulation therapy with heparin and vitamins K. The surgical treatment proved more efficient than the two other options.
Correction of oxidative stress in patients with chronic cerebral ischemia
Authors: Goroshko Olga A. , Novikov K. N. , Kukes V. G. , Voeikov V. L. , Arkhipov V. V. , Buravleva E. V. , Berdnikova N. G. , Zhestovskaya A. S.
Published: November 2020

A pilot study ofthe effect ofthe antioxidant drug ethylmethylhydroxypyridine malate on indicators of oxidative stress in patients with chronic cerebral ischemia. At 6 day course administration investigated the antioxidant in these patients significantly accelerates the process of generation of superoxide anion radical, established by lucigenin-depended chemiluminescence that probably regulate a feedback mechanism oxidase systems. This increases the activity of superoxide dismutase, and reduced the concentration of secondary peroxidation product - malondialdehyde, making reasonable use of antioxidants in the treatment of this pathology.
Peculiarities of progression of chronic glomerulonephritis associated with anemia
Authors: Murkamilov Ilkhom T. , Aitbaev K. A. , Kaliev R.
Published: November 2020

Aim.To study the influence of renal anemia on the clinical course of chronic kidney disease in patients with chronic glomerulonephritis (CGN) at the early stage of the disease. Materials and methods. This prospective 12 month study included evaluation of clinical and laboratory characteristics of 149 patients aged 17-66 (mean 37,6±12,6) years at the pre-dialysis stage of CGN (92 men (37,04±13,4 yr) and 57 women (38,2±11,2 yr). Results. By the end ofprospective observation, patients of group 1 (CGN without anemia) showed a decrease of the hemoglobin level accompanied by the impairment of nitrogenreleasing function with the glomerular filtration rate of 70,1 (43,1-111) ml/min compared with 87 (61,3-115,3) at the onset of observations (p<0,05). In group 2 (CGN with anemia), dynamics of the nitrogen-releasing function was similar but even more pronounced with the glomerular filtration rate reduced to 47,4 (32,2-91,8) ml/mincompared with 80,7 (39,8-107,9) at the onset of observations (p<0,05) and the serum creatinine level increased to157 (92-242) mcmol/l compared with 123 (86-171) (p<0,05). Conclusion. Reduction of hemoglobin level in patients with CGN is apparent at the early stages of the disease in association with impairment of glomerular filtration. The data obtained indicate that anemia can be a laboratory predictor of deteriorated nitrogen-releasing function.
Cardioprotrective effect of remote postconditioning: Mechanisms and possibilities of clinical application
Authors: Maslov Leonid N. , Tsibul’nikobv S. Yu. , Tsepokina A. V. , Khutornaya M. V. , Kutikhin A. G. , Gurin A. V. , Basalai M. V. , Mrochek A. G.
Published: November 2020

Experimental data indicate that postconditioning at a distance is an effective method for cardiac protection against reperfusion injury. Remote postconditioning prevents reperfusion necrosis and apoptosis of cardiomyocytes, decreases a probability of postinfarction remodeling of the heart. Cardioprotective effect of remote postconditioning depends on the release of tissue factor(s) increasing cardiac tolerance to long-term ischemia-reperfusion after transient ischemia. Clinical investigations show that postconditioning at a distance is an effective method for the prevention of reperfusion injury of the heart during coronary artery bypass surgery.
Characteristic of apoptosis of coronary artery cells with atherosclerotic lesions
Authors: Vladimirskaya Tatyana E. , Shved I. A.
Published: November 2020

Aim. To study apoptosis of endothelial cells (EC), macrophages (MF) and smooth muscle cells (SMC) in the early atherosclerotic process (prior to plaque formation), elucidate mechanisms of its realization and evaluate effect on progression of atherosclerosis. Materials and methods. Histopathological studies were performed on coronary arteries affected by atherosclerosis takenat autopsy of patients with coronary heart disease (n = 63). To detect apoptosis, the TUNEL method was used for calculating the apoptotic index (AI) in paraffin sections. Phenotyping the cells and test for expression of active caspase 3 (AC-3) and apoptosis-inducing factor (AIF) were performed using sections of coronary arteries stained by immunohistochemistry. Results. The study of apoptosis showed a significant (p <0.0001) increase in AI of SMC, EC, MF coronary arteries affected by atherosclerosis compared with unaffected vessels. Progression of the atherosclerotic process led to a decrease of AI of SMC and EC. Statistical analysis revealed moderate feedback between AI of SMC and neointimal thickness in the development of atherosclerotic lesions (r = -0,44, p <0.0001). The amount of the AC-positive SMC and EC at the stage of lipoidosis significantly (p <0.0001) exceeded the number of AC -positive SMC at the liposclerosis stage. Expression of AIF was observed in the nuclei of EC in the newly formed vessels of hyperplastic intima. Conclusions. Early atherosclerotic lesions of the coronary arteries are accompanied by intense apoptosis of SMC, EC and MF. The intensity of apoptosis of SMC and EC decreases with the development of atherosclerosis. Progression of intimal hyperplasia at the early stages of atherosclerosis is associated with reduced apoptosis of smooth muscle cells and enhanced macrophage apoptosis. Apoptosis of SMC and MF is caspase-dependent. Apoptosis of endothelial cells can occur both with the participation of caspases and independently of them (with AIF).