bluuebunny/crossref_metadata_2025 huggingface dataset:
TÜRK ATASÖZLERİNDE GEÇEN BAZI HAYVAN İMGELERİ ÜZERİNE TESPİTLER
Authors: KÜÇÜK Serhat , ZEYREK Selin
Published: October 2023

Atasözleri, bilgi ve deneyim yoluyla kalıplaşarak günümüze kadar ulaşmış sözlü kültür unsurlarıdır. İnsana dair hem maddi hem de manevi değerleri barındıran atasözleri, kültürü direkt olarak aktarma özelliğine sahiptir. Tabiatın, insanların, toplumların ve dünya görüşlerinin yansımalarını bulabileceğimiz atasözlerinde insan davranışları ve eylemleri ile olaylara yönelik anlamlar bulunur. İnsanoğlu uzun yıllar boyunca diğer insanlarla etkileşime girdiği gibi, doğadaki diğer canlılarla beraber yaşamış ve onlara bazı anlamlar yüklemiştir. Bu noktada, doğanın bir parçası olan hayvanlar, atasözlerinde kendilerine sıklıkla yer bulmuştur. İnsanlar başlarından geçen olay ve tecrübeleri anlatırken hayvanlara yer vermiş, böylece bir imge dili oluşturmuştur. Toplumların yaşam biçimlerini ve değer yargılarını açığa çıkaran atasözlerindeki hayvan imgelerini kullanan insanlar, bu şekilde görüş ve düşüncelerini daha etkili bir anlatımla sunma fırsatı bulmuştur. Bu manada atasözlerinde belirli ölçülerde ve farklı şekillerde kullanılan hayvan imgeleri, insanın doğadan aldığı bir ifade biçimi olarak kendini göstermektedir. Kalıp ifadelerden oluşan atasözlerinde benzetme yolu olarak belirleyici bir unsur olan hayvanların kullanımı, dile sanatsallık katmak ile kavramsal düşünme hususunda önem teşkil etmektedir. Söze güç kazandırma konusunda etkili olan hayvan imgelerinin kullanımı, sadece Türk Dili için değil diğer Türki dillerde de sıklıkla karşılaşılan bir yöntemdir.

Bu çalışmada, Türk atasözlerinde kullanılan bazı hayvan imgeleri üzerine tespitler yapılmaya çalışılmıştır. Seçilen hayvan imgelerinin tanım ve yapılandırmaları üzerinden tertip edilen açıklamalarla bir değerlendirme sunulmaya çalışılmıştır.
Influence of pH-cycling and abrasion wear on the mechanical properties of conventional and bulk fill resin composites
Authors: Orlando Larissa Daniela , Lins Rodrigo Barros Esteves , Santi Marina Rodrigues , Martins Luís Roberto Marcondes
Published: October 2023

The objective of this study was to evaluate the effect of abrasion wear on surface roughness and microhardness of different commercially available resin composites simulating pH-challenges of the oral cavity. Methods: Three resin composites (RC) were used in this study: one conventional: Z250; and two bulk fill resin composites (BRC): Tetric N-Ceram (TNC) and Sonic Fill (SF). The RC was inserted in a prefabricated mold (15mm wide x 4mm thickness) in two layers, or in a single layer for BRC. Thirty samples were prepared and surface roughness (Ra) and Knoop microhardness (KHN) test were performed at three different time-points of evaluation: baseline (24h after sample preparation); partial (after pH cycling); and final (after simulated toothbrushing procedure). Two samples of each group were selected after different treatments and analyzed descriptively on a scanning electron microscopy (SEM). Data from Ra and KHN were analyzed by two-way repeated-measures ANOVA and Bonferroni’s post-hoc test with a significance level set at 5%. Results: Ra increased for all groups (p<0.001), at the final time-point, Z250 and TNC groups present the highest values. Oppositely, KHN decreased for all groups (p<0.001), Z250 group showed the highest KHN values for all time-points (p<0.001). The SEM imagens showed a regular surface for samples cycled and irregular with inorganic particles exposed for samples toothbrushed. Conclusion: pH-cycling and simulated toothbrushing affected the superficial properties (roughness and Knoop microhardness), as observed at SEM imagens, with irregular surface with inorganic particles exposure.
Immigrants, Foreign Workers and Bilateral Trade: Evidence from Türkiye
Authors: Gençosmanoğlu Ömer Tarık
Published: October 2023

This study scrutinizes distinctively the impact of immigrants and foreign workers on Türkiye’s bilateral trade with their countries of origin. For this purpose, we use data related to the total migration stock of the country and the foreign workers in Turkish firms from 2015 to 2021. Poisson Pseudo Maximum Likelihood (PPML) estimation results indicate a positive association between migration and trade in Türkiye in line with previous studies. The results show that a 10% growth in the immigrant stock from a country contributes to Türkiye's exports to that country by 1.8% and imports from that country by 1.4%. These effects are 1.6% and 2.4%, respectively, in the case of foreign workers per se. The findings partially confirm that the trade facilitating effects of foreign workers, which are assumed to be more qualified than the average in terms of education, skill, and experience, are larger than all immigrants. To put it differently, immigrants generally improve Türkiye's exports more than skilled immigrants who increase its imports less than immigrants overall.
The Role of Mineral and Synbiotic to Enhance Immunity During Covid-19 Pandemic : A Literature Review
Authors: Setyaningtyas Stefania Widya , Atmaka Dominikus Raditya , Rachmah Qonita , Haryana Nila Reswari , Rifqi Mahmud Aditya , Diana Rian , Nastiti Aliffah Nurria , Agustin Asri Meidyah
Published: October 2023

COVID-19 has become a pandemic in the last 3 years worldwide and cases cause high mortality and morbidity. To reduce COVID-19 infection, we need to keep our immune system healthy. Several nutrients have been shown to have specific abilities to increase the power of the immune system, but their use in the treatment of COVID-19 is still being debated. This review aims to determine the role of minerals and synbiotics in increasing immunity during the COVID-19 pandemic. Specific minerals such as zinc, selenium, iron and copper have promising potential to treat COVID-19 by reducing clinical impact, markers of inflammation, and improving immunological biomarkers. In addition to increasing mineral intake, maintaining a healthy immune system can also be done by improving the health of the gut microbiota. One of the therapies that is considered to have a positive impact on handling COVID-19 is using synbiotics (a combination of prebiotics and probiotics). However, the safety and efficacy of mineral and synbiotic supplementation in COVID-19 patients as adjunctive therapy still requires further research. Minerals and synbiotics can help boost the immune system and reduce symptoms during a COVID-19 infection.
Study of Satisfaction towards the Food Services in the PPLP and SKO Athlete Dormitories in Indonesia
Authors: Penggalih Mirza Hapsari Sakti Titis , Sofro Zaenal Mutaqqien , Laksono Trisnantoro  , Edi Nurinda Susila  , Ernawaty  , Bayu Rahadian  , Margono  , Dadi Sujadi  , Raden Isnanta  , Hardiyanti Marina , Nia Bactiar  , Ghany Remaydhina Mahsa Alvita
Published: October 2023

Providing food for athletes is a special institutional arrangement that caters to athletes' specific needs. Athletes have different nutritional requirements than the non-athlete population, as they need more nutrients to compensate for the energy expended during training, competitions, and recovery after matches. Additionally, athletes must focus on fluid intake and sufficient nutrients to support post-training recovery for optimal performance. Therefore, meeting the needs and satisfaction of athletes becomes a crucial goal for athlete food service. Satisfaction can be assessed based on various indicators such as variety of menu and ingredients, suitable portion size, taste, serving time, packaging, and food handler hygiene. This study aims to assess athletes' satisfaction with the food service in athlete dormitories. The research is an observational survey with a cross-sectional approach involving 159 athletes aged 13-19 years from PPLP West Java, PPLP DIY, PPLP NTB, and SKO Cibubur. Data collection took place in May and July 2022. The research instrument used was a customer satisfaction survey questionnaire with a Likert scale ranging from 1 to 4, where one indicates 'very poor' and four indicates 'excellent.' The analysis technique used Pearson correlation in SPSS 16.0 software. The research showed a relationship between menu variety, ingredient variety, suitable portion size, serving time accuracy, food packaging, serving area, food handler hygiene, food presentation, and food taste with athletes' satisfaction level. Serving time accuracy, food packaging, hygiene, cleanliness of the serving area, food handler hygiene, food appearance, and taste correlate strongly with satisfaction.
Tissue-specific bioaccumulation and health risks of bisphenols in wild fish from West and North Rivers, South China
Authors: Liu Yue-Hong , Huang Jun-Wei , Huang Zheng , Mei Yu-Xian , Zhao Jian-Liang , Ying Guang-Guo
Published: October 2023

Bisphenols (BPs) are endocrine disruptors (EDCs) that produce hormone effects and other toxic effects. Due to their widespread use, BPs enter into the environment, such as rivers, and hence may accumulate in aquatic organisms. In this study, we investigated the tissue-specific bioaccumulation of BPs in different wild fish species in the North and West Rivers of the Pearl River system, South China, and assessed the human health risks via fish consumption. Firstly, the pretreatment method for 15 BPs in different fish tissues (muscle, liver, bile, plasma, intestine, and stomach) was established, and the target BPs were analyzed using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The total concentration of BPs in surface water was up to 1,530 ng/L. Bisphenol A (BPA), bisphenol F (BPF), and bisphenol F (BPF) were the dominant ingredients. BPs were widely detected in fish tissues. Among them, BPF had the highest detection efficiency and the concentration in fish muscle and liver tissues were 401 and 6,257 ng/g ww, respectively. BPA and BPAF had the highest detection efficiencies, with concentrations of 434 and 357 ng/g ww in intestine, respectively, and of 14 and 26 ng/g ww in stomach, respectively. BPA had the highest detection efficiency and concentration in fish bile up to 17,160 ng/mL. BPAF had the highest detection efficiency and concentration of 8 ng/g ww in fish plasma. Liver and intestine showed log bioaccumulation factors up to 6.93 L/kg, exhibiting high bioaccumulation ability for BPs into biota. The hazard quotients of human exposure risks of BPA via consumption of fish muscle were in the range of 4.97 × 10-4-8.97 × 10-4, indicating a low health risk of BPA through daily fish consumption.
A Comprehensive Review of Current Developments and Future Outlook Pertaining to Electronic Medical Records in the Context of Saudi Arabia, Aimed at Enhancing the Healthcare System
Authors: Siddiqui Muhammad Usman Hassan , Majeed Faisal
Published: October 2023

The contemporary landscape of eHealth is characterized by major concerns related to electronic medical records (EMRs). In an EMR, critical patient health information gets its own repository, which is the core of the eHealth system. Notably, the EMR not only retrieves health information generated in ambulatory clinical settings but also includes court-generated records. These overlapping records assume the role of a foundational data source for a comprehensive electronic health record (EHR). This scholarly review sheds light on recent trends in medical records and associated challenges, while at the same time providing insights into Saudi Arabia’s targeted approaches to healthcare delivery. Additionally, the talk expands to include a description of blockchain technology and its underlying conceptual framework. This demonstration positions blockchain technology as a promising approach that requires consideration for future use in the healthcare system.
The Effect of Melasma on the Quality of Life in People with Darker Skin Types Living in Durban, South Africa
Authors: Mpofana Nomakhosi , Paulse Michael , Gqaleni Nceba , Makgobole Mokgadi Ursula , Pillay Pavitra , Hussein Ahmed , Dlova Ncoza Cordelia
Published: October 2023

Melasma is a common skin disorder of acquired hyperpigmentation that appears commonly on the face. Although asymptomatic, melasma causes psychosocial and emotional distress. This study aimed to assess melasma's severity on people with darker skin types, evaluate the effects of melasma on the Quality of Life (QoL), and establish QoL predictors in affected individuals. This was a cross-sectional analytic study that enrolled 150 patients who were diagnosed with melasma from three private dermatology clinics in Durban, South Africa. The severity of melasma and QoL were measured using a Melasma Area and Severity Index (MASI) score, and Melasma Quality of Life scale (MELASQoL), respectively. The factors associated with impaired QoL were also explored using the multivariate method and stepwise regression analysis. MASI score of Masi (β = 0.209, t = 2.628, p < .010), involvement of cheeks (β = -0.268, t = -3.405, p <.001), level of education (β = -0.159, t = -2.029, p =.044) and being menopausal (β = -0.161, t = -2.027, p =.045) were found to be predictors of QoL. A regression model to predict MELASQoL given these four predictors was developed. The significance of the equation can allow remote scoring of MELASQoL based on the four variables.
Current Status and Molecular Mechanisms of Resistance to Immunotherapy in Oral Malignant Melanoma
Authors: Usta Sena Zeynep , Uchihashi Toshihiro , Kodama Shingo , Kurioka Kyoko , Inubushi Toshihiro , Shimooka Takuya , Sugauchi Akinari , Seki Soju , Tanaka Susumu
Published: October 2023

Immune checkpoint inhibitors (ICIs), including anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death-1 (PD-1) antibodies, have initiated a new era in the treatment of malignant melanoma. ICIs can be used in various settings, including as first-line, adjuvant, and neoadjuvant therapy. In the scope of this review, we examined clinical studies utilizing ICIs in the context of treating oral mucosal melanoma, a rare disease albeit with an extremely poor prognosis, with a specific focus on unraveling the intricate web of resistance mechanisms. The absence of a comprehensive review focusing on ICIs in oral mucosal melanoma is notable. Therefore, this review seeks to address this deficiency by offering a novel and thorough analysis of the current status, potential resistance mechanisms, and future prospects of applying ICIs specifically to oral malignant melanoma. Clarifying and thoroughly understanding these mechanisms will facilitate the advancement of effective therapeutic approaches and enhance the prospects for patients suffering from oral mucosal melanoma.
Influence of Energetic Particles and Electron Injection on Minority Carrier Transport Properties in Gallium Oxide
Authors: Modak Sushrut , Ruzin Arie , Schulte Alfons , Chernyak Leonid
Published: October 2023

The influence of various energetic particles and electron injection on transport of minority carriers and non-equilibrium carrier recombination in Ga2O3 is summarized in this review. In Ga2O3 semiconductor, if robust p-type material and bipolar structures become available, diffusion length of minority carriers will be of critical significance. Diffusion length of minority carriers dictates functionality of such electronic devices as diodes, transistors, and detectors. One of the problems in ultra-wide band gap materials technology, is the short carrier diffusion length, due to scattering on extended defects. Electron injection in n- and p-type Gallium Oxide results in a significant increase of the diffusion length, even after its deterioration due to exposure to alpha- and proton-irradiation. Furthermore, post electron injection diffusion length in irradiated material exceeds that in Ga2O3 prior to irradiation and injection. The root cause of the electron injection-induced effect is attributed to the increase of minority carrier lifetime in the material due to trapping of non-equilibrium electrons on native point defects. It is, therefore, concluded that the electron injection is capable of “healing” the adverse impact of radiation in Ga2O3 and can be used for control of minority carrier transport and, therefore, device performance.
Understanding the Role of Activation Loop Mutants in Drug Efficacy for FLT3-ITD
Authors: Kazi Julhash U. , Al Ashiri Lina , Purohit Rituraj , Rönnstrand Lars
Published: October 2023

The type III receptor tyrosine kinase FLT3 is a pivotal kinase for hematopoietic progenitor cell regulation, with significant implications in acute myeloid leukemia (AML) through mutations like internal tandem duplication (ITD). This study delves into the structural intricacies of FLT3, the roles of activation loop mutants, and their interaction with tyrosine kinase inhibitors. Coupled with this, the research leverages molecular contrastive learning and protein language modeling to examine interactions between small molecule inhibitors and FLT3 activation loop mutants. Utilizing the ConPLex platform, over 5.7 million unique FLT3 activation loop mutants-small molecule pairs were analyzed. The binding free energies of three inhibitors were assessed, and cellular apoptotic responses were evaluated under drug treatments. Notably, the introduction of the Xepto50 scoring system provides a nuanced metric for drug efficacy. The findings underscore the modulation of molecular interactions and cellular responses by Y842 mutations in FLT3-KD, highlighting the need for tailored therapeutic approaches in FLT3-ITD-related malignancies.
Recent Advances in Space Debris Removal Techniques; A study
Authors: Deghuria Ayan , Debnath Richeek , G Varsha , Raheja Khushi
Published: October 2023

Space debris, which includes retired satellites, used rocket stages, and explosion- or collision-related bits, poses a serious threat to both ongoing and future space activity. Addressing the problem of space debris has become essential for the sustainability of space operations due to the exponential development in satellite deployments and space research. The development of technology and tactics aimed at reducing the debris problem and assuring a cleaner cosmos are the main topics of this abstract, which provides an outline of the idea of sustainable space debris management and removal. The paper opens by outlining the history of space debris and the major difficulties caused by space debris, such as the dangers to functioning satellites, the possibility of catastrophic collisions, and the production of more debris as a result of cascade occurrences. The paper then emphasized the guidelines of space debris mitigation. It emphasizes the pressing requirement for long-term fixes that tackle the issue at its root. The paper then discusses different methods for managing space debris, such as proactive measures, active debris removal (ADR). It talks about how important it is to use sustainable methods during every stage of a space mission's lifecycle, from design and operation to deorbiting and disposal. This paper concludes with a summary of sustainable space debris removal, noting the difficulties caused by debris and the demand for all-encompassing approaches and technology to address this issue. It emphasizes how crucial global collaboration, technological development, and institutional frameworks are to creating a sustainable and debris-free space environment.
Effects of Zeolite and Deficit Irrigation on Sweet Pepper Growth
Authors: Castronuovo Donato , Satriani Antonio , Rivelli Anna Rita , Comegna Alessandro , Belviso Claudia , Coppola Antonio , Di Prima Simone , Cavalcante Francesco , Lovelli Stella
Published: October 2023

The use of zeolite in agriculture as a soil conditioner is becoming an important field of research in crop growth. To study the effect of synthetic zeolite and deficit irrigation on sweet pepper (Capsicum annuum L.) cultivation, an experiment in a controlled environment was conducted. In particular, sweet pepper was cultivated in a glasshouse using polypropylene pots filled with sandy-loam soil to which 2% of zeolite was added. The zeolite employed in the experiments was obtained using coal fly ash as raw material. The experiment was planned in order to have two main treatments consisting of a) soil with zeolite at 2% (Z) and b) soil without zeolite, as control (C), and three subplot treatments consisting of 1) full irrigation at 100% of available water content (AWC) (100); 2) deficit irrigation at 70% of AWC (70); 3) deficit irrigation at 50% of AWC (50). Sweet pepper cultivation started on the 24th April 2023 and lasted until the 23th June 2023 and during the trial environmental data, such as soil humidity, air temperature and relative humidity, and some crop parameters, such as plant height, leaf number, SPAD index, were monitored. At the end of the trial, fresh and dry plant weight, dry matter content, and leaf water potential were measured. Results showed that for plant fresh weight and dry matter content, no significant differences were observed by treatments and their interactions whereas for the other parameters the statistical analysis returned significant differences. The study suggests that the soil structural benefits, resulting from the zeolite application, are not followed by an equal positive effect in terms of sweet pepper growth under deficit irrigation conditions.
Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan
Authors: Lee Yeongjoo , Jang Jaehyuk , Na Sae Jung
Published: October 2023

In this presented case, a 77 years old woman suffering from ongoing knee pain underwent a bone scan using 99mTc-hydroxydiphosphonate (HDP) in suspicious for bone infection. An incidental finding from this scan revealed diffuse cardiac uptake, necessitating further diagnostic procedures to exclude the possibility of cardiac amyloidosis. In the subsequent 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and SPECT images, no perceptible cardiac uptake was observed at all. Upon retrospective review of the patient’s medical records, she had received 1000mg of ferric carboxymaltose for iron-deficient anemia, the day before the 99mTc-HDP bone scan. Therefore, it is assumed that the diffuse and temporary cardiac activity was due to the transient iron overload. We present and share this bone scan images in order to avoid possible future misinterpretation of cardiac amyloidosis.
Predicting Body Fat Percentage: A Machine Learning Approach
Authors: SANTOS DHEIVER
Published: October 2023

Accurate estimation of body fat percentage is essential for various health and fitness applications. Traditional methods for measuring body fat, such as underwater weighing, can be costly and inconvenient. In this study, we apply machine learning techniques to predict body fat percentage using easily accessible body measurements and data. The results highlight the effectiveness of regression models in estimating body fat, with Linear Regression, Ridge Regression, and Bayesian Ridge models achieving R-squared scores of approximately 74%, 73%, and 73%, respectively. These models provide a practical and cost-effective solution for individuals and professionals seeking reliable body fat estimates.
Evaluation of Growth Performance and Environmental Impact of Hermetia illucens Larvae Reared on Coffee Silverskin Enriched with Schizochytrium limacinum or Isochrysis galbana Microalgae
Authors: Sara Ruschioni , Daniele Duca , Francesca Tulli , Matteo Zarantoniello , Gloriana Cardinaletti , Lorenzo Corsi , Ike Olivotto , Danilo Basili , Naspetti Simona , Truzzi Cristina , Isidoro Nunzio , Paola Riolo
Published: October 2023

Hermetia illucens is a very promising insect due to its ability to convert low-value substrates in highly nutrient feed. Its feeding and nutrition are important issues. This work aimed to study the effect of different substrates composed of coffee silverskin, by-product of the roasting process, enriched with different inclusion of microalgae (5%, 10%, 20%, 25%), Schizochytrium limacinum and Isochrysis galbana, coupled with the assessment of environmental sustainability by LCA. In general, the inclusion of microalgae caused an increase in the growth performance of the larvae, although S. limacinum showed the best results. Higher prepupal weight were observed in larvae fed on 20% and 25% of S. limacinum, shorter development times in larvae fed on 25% of both S. limacinum and I. galbana and higher growth rate were observed in larvae fed on 25% of S. limacinum. Anyway, the inclusion of 10% of S. limacinum showed a small difference with the higher inclusions. Moreover, the 10% of S. limacinum achieved the best waste reduction index. Therefore, considering the greater inclusion of microalgae, the higher the environmental impact of larvae production, the addition of 10% of S. limacinum seems to be the best compromise for the larval rearing.
NanoBubble-mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-related Pathologies
Authors: Viafara-Garcia Sergio M. , Khan Muhammad Saad , Haidar Ziyad S. , Acevedo Cox Juan Pablo
Published: October 2023

Worldwide, hypoxia-related conditions, including cancer, COVID-19, and neuro-degenerative diseases, often lead to multi-organ failure and significant mortality. Oxygen, crucial for cellular function, becomes scarce as levels drop below 10 mmHg (<2% O2), triggering mitochondrial dysregulation and activating hypoxia-induced factors (HiFs). Herein, Oxygen nanoBubbles (OnB), an emerging versatile oxygen de-livery platform, implies to offer a novel approach to address hypoxia-related pathologies. This review explores OnB oxygen delivery strategies and systems, including diffusion, ultrasound, photodynamic, and pH-responsive nanobubbles. It delves into the nanoscale mechanisms of OnB, elucidating their role in mitochondrial metabolism (TFAM, PGC1alpha), hypoxic responses (HiF-1alpha), and their interplay in chronic pathologies including cancer and neurodegenerative disorders, amongst others. By understanding these dynamics and underlying mechanisms, this article aims to contribute to our accruing knowledge of OnB and the developing potential in ameliorating hypoxia- and metabolic stress-related conditions and fostering innovative therapies.
On Weakly Tripotent and Locally Invo-Regular Rings
Authors: Pandey S K
Published: October 2023

In this article some important observations have been reported on recent works related to weakly tripotent rings and locally invo-regular rings. Our findings give additional results as well as correct some recent results on weakly tripotent rings and locally invo-regular rings appeared in Rendiconti Sem. Mat. Univ. Pol. Torino (2021) and Azerbaijan Journal of Mathematics (2021) respectively.
Moving Towards a Mutant-Based Testing Tool for Verifying Behavior Maintenance in Test Code Refactorings
Authors: Teixeira Tiago Samuel Rodrigues , Silveira Fábio Fagundes , Guerra Eduardo Martins
Published: October 2023

Evaluating mutation testing behavior can help decide whether refactoring successfully maintains the expected initial test results. Moreover, manually performing this analytical work is both time-consuming and prone to errors. This paper extends an approach to assess test code behavior and proposes a tool called MeteoR. This tool comprises an IDE plugin to detect issues that may arise during test code refactoring, reducing the effort required to perform evaluations. A preliminary assessment was conducted to validate the tool and ensure the proposed test code refactoring approach is adequate. By analyzing not only the mutation score but also the generated mutants in the pre- and post-refactoring process, results show that the approach is capable of checking whether the behavior of the mutants remains unchanged throughout the refactoring process. This proposal represents one more step toward the practice of test code refactoring. It can improve overall software quality, allowing developers and testers to safely refactor the test code in a scalable and automated way.
Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease
Authors: Francisco Amanda Fortes , Sousa Giovane R. , Vaughan Mhairi , Langston Harry , Khan Archie , Jayawardhana Shiromani , Taylor Martin C. , Lewis Michael D. , Kelly John M.
Published: October 2023

Chronic Chagas Cardiomyopathy (CCC) results from infection with the protozoan parasite Trypanosoma cruzi and is a prevalent cause of heart disease in endemic countries. We previously found that cardiac fibrosis can vary widely in C3H/HeN mice chronically infected with T. cruzi JR strain, mirroring the spectrum of heart disease in humans. In this study, we examined functional cardiac abnormalities in this host:parasite combination to determine its potential as an experimental model for CCC. We utilized electrocardiography (ECG) to monitor T. cruzi-infected mice and determine whether ECG markers could be correlated with cardiac function abnormalities. We found that the C3H/HeN:JR combination frequently displayed early onset CCC indicators, such as sinus bradycardia and right bundle branch block, as well as prolonged PQ, PR, RR, ST and QT intervals in the acute stage. Our model exhibited high levels of cardiac inflammation and enhanced iNOS expression in the acute stage, but denervation did not appear to have a role in pathology. These results demonstrate the potential of the C3H/HeN:JR host:parasite combination as a model for CCC that could be used for screening new compounds targeted at cardiac remodeling and for examining the potential of anti-parasitic drugs to prevent or alleviate CCC development and progression.
Conjugate Gradient Least Squares Algorithm for OFDM Nonlinear Equalization in Intelligent Future IoT Transportation Systems
Authors: Attar Hani , Aljaidi Mohammad , Alrosan Ayat , COLAK Ilhami , Solyman Ahmed , Agieb Ramy Said
Published: October 2023

Intelligent transportation systems (ITS) have recently evolved rapidly, which requires development of highly trustworthy and effective communication technologies for uses, including vehicle-to-vehicle (V2V) and vehicle-to-everything (V2X) communication; where Orthogonal Frequency Division Multiplexing (OFDM) is regarded as a strong candidate and highly popular option technique among these methods. However, the movement of vehicles introduces Doppler frequencies which produce inter-carrier interference (ICI), that is frequently occurs in V2X channels. This interference has the potential to compromise the integrity of subcarrier orthogonality within OFDM, leading to lower-quality communication and an increased likelihood of data transmission errors. When employing channels with doubly dispersive fading, OFDM necessitates the usage of a complex equalization based on the minimum mean-square error (MMSE) equalizer, which requires channel matrix inversion. Several low-complexity equalizers for OFDM have been developed and are based on band factorization, time domain LSQR (Least-Square QR) iterative computing, and banded minimum mean squared error (BMMSE). This paper proposes Conjugate Gradient Least Squares (CGLS), which is a novel iterative computation algorithm integrated with nonlinear equalizers. The suggested nonlinear equalization technique determines the trade-off between computations and performance. According to simulation data, the suggested nonlinear equalizer performs better than the current BMMSE and linear CGLS algorithms across doubly dispersive fading channels.
Template-free Manufacturing of Defined Structure and Size polymeric Microparticles
Authors: Abdurashitov Arkady S. , Proshin Pavel I. , Sukhorukov Gleb B.
Published: October 2023

Complex-structured polymeric microparticles hold significant promise as advance in next-generation medicine mostly due to demand from developing targeted drug delivery. However, the conventional methods for producing these microparticles of defined size, shape and sophisticated composition often face challenges in scalability, reliance on specialized components such as micro-patterned templates, or have limited control over particle size distribution and cargo release kinetics. In this study, we introduce a novel and reliably scalable approach for manufacturing microparticles of defined structures and sizes with variable parameters. The concept behind this method involves the deposition of a specific number of polymer layers on a substrate with low surface energy. Each layer can serve as either the carrier for cargo or a programmable shell-former with predefined permeability. Subsequently, this layered structure is precisely cut into desired-sized blanks using a laser. The manufacturing process is completed by applying of heat to the substrate what results on sealing the edges of the blanks. The combination of the high surface tension of the molten polymer and the low surface energy of the substrate enables the formation of discrete particles, each possessing semi-spherical or other designed geometries determined by their internal composition. Such anisotropic microparticles are envisaged versatile applications.
Generalized Partially Functional Linear Model with Unknown Link Function
Authors: Xiao Weiwei , Li Songxuan , Liu Haiyan
Published: October 2023

In this work, we propose a generalized partially functional linear model, which not only models the relationship between multiple scalar and functional predictors and response, but also automatically estimates the link function. Specifically, we use the functional principal component analysis method to reduce the dimensionality of functional predictors, estimate the regression coefficients using the maximum likelihood estimation method, estimate the link function using the method of local linear regression, iteratively obtain the final estimator, and prove the asymptotic normality of the estimator. The asymptotic normality is illustrated through simulation experiments. Finally, the proposed model is applied to study the influence of environmental, economic, and medical levels on life expectancy in China. In the study functional predictors are the daily air quality index, temperature, and humidity of 58 cities in 2020 and scalar predictors are GDP and number of beds in hospitals.
Talaramide: A New Ceramide from the Cytotoxic Extract of the Endophytic Fungus Talaromyces wortmannii
Authors: Abdel Bar Fatma M. , Galala Amal A. , El-Sokkary Mohamed M. , Khalil Ashraf T. , Sallam Amal
Published: October 2023

Endophytic fungi isolated from plants of different ecosystems have an impressive ability to produce diverse chemical classes of bioactive secondary metabolites. In this study, the cytotoxic activity and chemical composition of the ethyl acetate extract of the white beans culture of the endophytic fungus (FWBC), Talaromyces wortmannii isolated from the widespread reed grass, Arundo donax L. were investigated. A new ceramide named talaramide (1), along with other four known compounds; stigmasterol (2), thymine (3), uracil (4), and stigmasterol-3-O-β-D-glucoside (5) were identified. The structure of compound 1 was elucidated based on extensive 1D and 2D NMR spectroscopic techniques in combination with HR-ESI-MS. The produced FWBC extract exhibited cytotoxic activity against three cancer cell lines viz., MCF7, HepG2, and A549 (IC50; 54.57 ±0.27, 57.12 ± 0.59 and 84.33 ± 1.07 µg/mL, respectively) compared to methotrexate (IC50; 80.25 ± 1.11, 83.83 ± 0.74 and 153.20 ± 2.03 µg/mL, respectively) as a positive control. It showed selectivity indices with values ranging from 1.37 to 2.11 using the normal cell line, WI38 (IC50; 115.43 ± 1.92 µg/mL). The observed cytotoxicity, combined with acceptable selectivity indices, suggests the potential of this endophyte as a source of anticancer agents. Based on previous reports, it was also suggested that the identified ceramide could be responsible for the observed cytotoxic activity of the investigated extract.
Formulação, implementação e controle de políticas públicas no contexto “pós”: pós-modernidade, pós-democracia e pós-verdade como mudanças de paradigma
Authors: Moraes Maria Valentina de , Hennig Leal Mônia Clarissa
Published: October 2023

A existência de uma (nova) configuração estatal, marcada pela pós-modernidade e pela pós-democracia, traz novos elementos para que as políticas públicas, instrumentos de efetivação de direitos fundamentais, sejam pensadas e implementadas. Questiona-se, assim: Quais os entraves para a formulação, implementação e controle de políticas públicas com a mudança de paradigma trazida no contexto “pós”? Utilizando-se o método indutivo, é possível afirmar que todas as fases do ciclo das políticas públicas possuem obstáculos como a não resposta estatal a problemas sociais, a desconsideração da racionalidade e da técnica, a constitucionalização simbólica e desconstitucionalização fática, o abandono da cientificidade e manutenção das formas em detrimento do conteúdo, exigindo que as políticas públicas sejam repensadas a partir dos novos paradigmas estabelecidos.
La promoción social de los titulados universitarios en la corte de los Reyes Católicos: el caso del doctor Angulo
Authors: Martín Barba José Julio
Published: October 2023

Martín Fernández de Angulo –el doctor Angulo–, fue uno de los más íntimos colaboradores de los Reyes Católicos, que protagonizó un vertiginoso encumbramiento político y eclesiástico. Nos proponemos con el presente trabajo ofrecer una semblanza de sus primeros años, desde sus orígenes en Córdoba hasta su entrada en el círculo cortesano, analizando los elementos que le facilitaron la promoción.
Un acercamiento a la usurpación de armerías en Francia, los Países Bajos meridionales, España e Inglaterra durante la Edad Moderna
Authors: Valle Porras José Manuel
Published: October 2023

Este artículo intenta ofrecer, desde la perspectiva de la historia social, un acercamiento de conjunto al fenómeno de la usurpación de armerías durante la Edad Moderna, comparando las situaciones existentes en Francia, los Países Bajos Meridionales, Castilla, la Navarra española e Inglaterra. Puesto que las investigaciones sobre esta cuestión son aún escasas, y dada la amplitud geográfica abarcada en este trabajo, hemos recurrido fundamentalmente a fuentes impresas de la época (leyes, tratados teóricos y obras literarias), complementadas con ediciones de fuentes de archivo y algunas aportaciones científicas. El empleo de estos datos dispersos permite reconstruir un cuadro grosso modo común a los países estudiados, caracterizado por la asimilación de las armerías a la nobleza desde finales de la Edad Media y el consiguiente uso de las mismas como instrumento de ascenso social durante toda la Edad Moderna. Frente a esta situación, los Estados intervienen para determinar el tipo de armerías que corresponde a los nobles y evitar que las usen los plebeyos para infiltrarse en la nobleza. Sin embargo, los resultados fueron en general pobres. La apropiación de escudos y timbres indicativos de nobleza, así como de armas ajenas, fue común entre los siglos XVI y XVIII, e incluso los heraldos –teóricos encargados de vigilar la corrección de los escudos de armas– participaron, corrompidos, en estas prácticas.
Fernando de Torres y Portugal, conde de Villardompardo, y su intento frustrado de compra del lugar de Jamilena de la encomienda calatrava de Martos (1561)
Authors: Illana López Francisco Javier
Published: October 2023

Resumen: Este trabajo analiza la figura de Fernando de Torres y Portugal, I Conde de Villardompardo, atendiendo a su faceta señorial y nobiliaria, y profundizando en un caso concreto de la compra de jurisdicción: el lugar de Jamilena. Para ello se parte de fuentes localizadas en el Archivo Histórico Nacional y Archivo General de Simancas, con las que se pretende atender a un capítulo desconocido de la vida y obra de este aristócrata giennense de la segunda mitad del siglo XVI.Palabras clave: Fernando de Torres y Portugal, señorío, ventas jurisdiccionales, Villardompardo, Jamilena. Abstract: The aim of this paper is to study the figure of Fernando de Torres y Portugal, I Count of Villardompardo in the 16th Century. We pay attention to his noble image and analyze a specific event in his life: a jurisdiction sale in the village of Jamilena. We use documentary sources located in the National Historical Archive and General Archive of Simancas, in order to explain an unknown event in the life of this Spanish aristocrat.Keywords: Fernando de Torres y Portugal, estate, sales of jurisdictions, Villardompardo, Jamilena.
Real-time retrieval of atmospheric water vapor from shipborne Beidou Observations over the South China Sea
Authors: Wu Zhilu , Lu Cuixian , Han Xinjuan , Zheng Yuxin , Wang Bo , Wang Jungang , Liu Yang , Liu Yanxiong
Published: October 2023

Atmospheric water vapor plays a prominent role in weather forecasting and climate change, which can be measured accurately with not only the conventional water vapor observing techniques, but also the global navigation satellite system (GNSS). However, retrieving water vapor from GNSS is mainly limited to land, in particular for Beidou global navigation satellite system (BDS) which has started to provide global service since July 2020. In this contribution, we try to investigate retrieving the real-time precipitable water vapor (PWV) based on shipborne BDS kinematic precise point positioning (PPP) solutions, and an 8-day experiment over the South China Sea is carried out. The obtained BDS zenith total delay (ZTD) and PWV values are validated by the post-processed multi-GNSS (GPS + GLONASS + Galileo + BDS) ZTD and European Centre for Medium-Range Weather Forecasts (ECMWF) ERA5 PWV products, respectively. The results show that the real-time shipborne BDS ZTD estimates agree well with the post-processed multi-GNSS ZTDs, which shows a difference of approximately 2.0 cm in terms of root-mean-square (RMS) after an averaged initialization time of 43.9 mins. In addition, the real-time shipborne BDS PWV demonstrates an accuracy of 3.45 mm with respect to the ERA5 PWV products. Furthermore, observations from GPS-only system, Galileo-only system, GLONASS-only system, and multi-GNSS combination are also processed in real-time mode to derive the ZTD/PWV values. It is demonstrated that the overall performance of BDS in real-time ZTD/PWV retrieval is comparable to that of Galileo, better than that of GLONASS, but slightly worse than that of GPS. Attributing to the completion of its constellation, BDS is able to sense the atmospheric water vapor over oceans independently and contributes to the time-critical meteorological applications.
Modeling the Effects of Media Awareness on SARS-CoV-2 Transmission in Georgia
Authors: Preston Makayla , Carter Alexandria , Numfor Eric
Published: October 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in December 2019 poses an enormous threat in public health worldwide. The role of media coverage on disease outbreaks is crucial. Thus, we formulate an SEIR-type model of SARS- CoV-2 with two susceptible classes comprising individuals who are unconscious to SARS-CoV-2 spread and control and those who are conscious to SARS-CoV-2 spread and control due to media coverage. The disease-free equilibrium of our model is derived, and the media-dependent reproduction number (RM ) is computed. We established the existence of a unique endemic equilibrium when RM > 1, and investigated the local and global stability of the disease-free equilibrium when RM < 1. The Latin Hypercube Sampling technique is used to identify parameters that are sensitive in reducing the media-dependent reproduction number. Using data on the cumulative number of cases of symptomatic infections from the state of Georgia, we estimated unknown parameters of our model. Numerical simulations of our model suggest that an increase in the messaging rate of COVID-related information by conscious susceptible humans suggests a decrease in the media-dependent reproduction number and the number of cumulative cases of symptomatic infectious humans. Also, an increase in waning awareness of COVID-related information re- results in an increase in prevalence. These results highlight the importance of media on the transmission and control of SARS-CoV-2 in the population.
Mathematics Subject Classification (2020) 37N25 · 92B05
Unveiling the Axonal Connectivity Between the Precuneus and Temporal Pole: Structural Evidence from the Cingulum Pathways
Authors: Skandalakis Georgios P. , Linn Wen-Jieh , Yeh Fang-Cheng , Kazim Syed Faraz , Komaitis Spyridon , Neromyliotis Eleftherios , Dimopoulos Dimitrios , Drossos Evangelos , Hadjipanayis Constantinos G. , Kongkham Paul N. , Zadeh Gelareh , Stranjalis George , Koutsarnakis Christos , Kogan Michael , Kalyvas Aristotelis
Published: October 2023

Neuroimaging studies have consistently demonstrated concurrent activation of the human precuneus and
temporal pole, both during resting-state conditions and various higher-order cognitive functions. However,
the precise underlying structural connectivity between these brain regions remains uncertain despite
significant advancements in neuroscience research. In this study, we investigated the connectivity of the
precuneus and temporal pole by employing parcellation-based fiber micro-dissections in human brains
and fiber tractography techniques in a sample of 1,065 human subjects and a sample of 41 rhesus
macaques. Our results demonstrate the connectivity between the posterior precuneus area POS2 and the
areas 35, 36, TG, and TI of the temporal pole via the fifth subcomponent of the cingulum (CB-V) also
known as parahippocampal cingulum. This finding contributes to our understanding of the connections
within the posteromedial cortices, facilitating a more comprehensive integration of anatomy and function
in both normal and pathological brain processes.
Efficient Alzeihmer’s disease detection using Deep learning Technique
Authors: Sekhar BVDS , Jagadev Alok Kumar
Published: October 2023

The human brain serves as the primary control centre for the humanoid system. Computer vision plays a vital part in the field of human health, which helps to reduce the amount of human judgement that is required to produce accurate findings. Scans using computed tomography (CT), x-rays, and magnetic resonance imaging (MRI) are the most popular imaging technologies used in MRI, and they could also the greatest trustworthy and safe. The MRI can identify even the most minute of objects. In this paper Alzheimer’s disease detection in early-stage, based on MRI by using the deep learning technique U-Net and Efficient net which is a Convolutional neural network is implemented. Diagnosing of Alzheimer's disease (AD) accurately is an vital aspect in treating AD patients, eventually during the early disease stages. This is particularly true in the early disease stages of the disease, when awareness of risk, enables AD patients to takeup protective measures well before the occurrence of brain damage that cannot be reversed. Despite of the fact that computers have been utilised in a significant number of recent research to diagnose AD, the majority of machine detection approaches are restricted by congenital findings. Early-stage Alzheimer's disease (AD) can be identified, but early-stage AD cannot be predicted because prediction of the disease is successful only before the (AD) disease reveals itself. Deep Learning, often known as DL, has recently emerged as a popular method for the initial recognition of Alzheimer's disease (AD). In this article, we will give a quick overview of some of the key research that has been done on AD, and we will investigate how DL can assist researchers in the early phases of disease diagnosis.