bluuebunny/crossref_metadata_2025 huggingface dataset:
Percepções de Pacientes com Câncer sobre a Terapia Nutricional Oral mediante Suplementos Nutricionais durante o tratamento Quimioterápico
Authors: Ferreira Aline Ribeiro , Oliveira Maria Heloisa Moura de , Lima Larissa dos Santos Souza
Published: April 2024

Introdução: Frequentemente, a toxicidade dos tratamentos está associada à anorexia e perda de peso não intencional. A terapia nutricional oral (TNO) é um tipo de estratégia realizada por meio de suplementos nutricionais orais com a finalidade de complementar as necessidades nutricionais que dependem principalmente da adesão à terapêutica. Objetivo: Analisar a percepção e a adesão de pacientes com câncer em tratamento quimioterápico sobre a TNO e associá-las a fatores demográficos. Método: Pesquisa de campo qualitativa, com pacientes diagnosticados com qualquer tipo de câncer, entre 18 e 59 anos, em tratamento quimioterápico, em risco nutricional, atestado por instrumento de triagem nutricional e em uso de TNO. Foi realizada uma única entrevista, mediada por questionário semiestruturado. Os dados foram transcritos, classificados e analisados pelo método sugerido por Laurence Bardin. Resultados: Os resultados revelaram uma diversidade de respostas, mas houve uma tendência significativa para destacar as dificuldades no uso e na adesão da TNO, além de enfatizar sua importância. Entre as dificuldades de adesão, a mais citada foi a financeira, seguida das características sensoriais dos suplementos e das alterações gastrointestinais como náuseas, vômitos, disgeusia e inapetência. Conclusão: A percepção de pacientes com câncer sobre a TNO interfere na adesão à terapêutica, e sofre interferência da escolaridade, das orientações recebidas pelo profissional prescritor, das características sensoriais dos suplementos nutricionais utilizados e da importância que eles atribuem à terapêutica, além das condições socioeconômicas.
I es a noite, i es a aurora. A poética da luz en Rosalía de Castro
Authors:   Real Academia Galega, Angueira Viturro Anxo
Published: April 2024

Discurso lido no acto da súa recepción, polo ilustrísimo señor don Anxo Angueira Viturro e resposta da excelentísima señora dona Chus Pato O solemne acto académico en que foron lidos os dous discursos recolleitos no presente volume celebrouse o 27 de abril de 2024 no Auditorio municipal de Padrón. O autor percorre no seu discurso o desenvolvemento da poética da luz na obra de Rosalía de Castro, poética que acabou por converterse nun signo moi persoal e significativo a respecto de todo o conxunto da súa obra.
MULTIMODAL LOGISTICS IN THE CONDITIONS OF A TURBULENT BUSINESS ENVIRONMENT TRANSPORT & LOGISTICS SYSTEM
Authors:   Odesa State Environmental University, Tseller Vladyslav , Kramskyi Serhii ,   Odesa State Environmental University; Institute of Market and Economic&Ecological Researches of National Academy of Sciences of Ukraine
Published: April 2024

The transport industry of Ukraine is an important component of the complex of infrastructural industries and a necessary material factor for ensuring production and logistics. The importance and relevance of the development of transport logistics is also due to its special importance in ensuring the security of Ukraine, especially in conditions of military influence. That is, transport multimodal logistics indirectly affects all components of national security - foreign economic, domestic political, economic, food, environmental, anti-terrorist, informational, scientific and technical, and others. The economic role of transport consists, first of all, in the fact that it is an organic link of every production, carries out continuous and mass delivery of all types of raw materials, fuel and products from points of production to points of consumption, and also ensures the division of labor, specialization and cooperation of production. The purpose of the research is the analysis of the development of the multimodal transport logistics system of the surrounding business environment under the influence of the turbulence of the martial law and in the post-war period. One of the key advantages of multimodal logistics is the ability to use different types of transport depending on the specific stages of the route and infrastructure capabilities. This avoids delays and reduces the risk of loss of time and money. In addition, multimodal logistics allows the use of cargo tracking technologies, which facilitates control over their movement and ensures accurate delivery times. This is important for a business that seeks to provide quality service to its customers. Despite the fact that logistics services are usually complex and expensive, some Ukrainian companies offer them absolutely free of charge. Now Ukraine needs to overcome difficulties and look for new ways. Ensuring security has become the main priority for Ukrainian commodity exports. Summing up, multimodal transport logistics is a strategic approach to optimizing transport flows, which allows to ensure the efficiency and competitiveness of logistics processes in the modern world. Thus, logistics is actively studying the situation and cooperating with government authorities to find bypass logistics routes around dangerous zones and war-torn trade bridges.
ПОКРАЩЕННЯ СУБ’ЄКТИВНОГО БЛАГОПОЛУЧЧЯ СТУДЕНТСЬКОЇ МОЛОДІ В УМОВАХ ВІЙСЬКОВИХ ДІЙ
Authors: Помиткін Едуард Олександрович , Помиткіна Любов Віталіївна
Published: April 2024

У статті подані результати теоретико-емпіричного дослідження відчуття суб’єктивного благополуччя студентів в умовах військових дій, спричинених російською агресією; проаналізовані праці сучасних учених і дослідників щодо методів покращення суб’єктивного благополуччя; продемонстровані результати розробленої та впровадженої програми психологічного тренінгу щодо покращення основних характеристик суб’єктивного благополуччя молоді. Метою статті є висвітлення результатів апробації програми психологічного тренінгу підвищення рівня суб’єктивного благополуччя студентської молоді. Методики: «Модифікована шкала суб’єктивного благополуччя BBC» (адаптація Л. Карамушки, К. Терещенко, О. Креденцер); «Когнітивні особливості суб’єктивного благополуччя (КОСБ-3)» (О. Калюк, О. Савченко); «Шкала суб’єктивного благополуччя» Г. Перуе-Баду (в адаптації М. Соловйової). У процесі емпіричного дослідження вивчалися такі складники суб’єктивного благополуччя: психологічне благополуччя (упевненість у своїх думках і переконаннях, можливість власного розвитку як особистості тощо), фізичне здоров’я (якість сну, здатність працювати та здійснювати свою повсякденну життєву активність, заняття спортом і відпочинком, відсутність депресії, тривоги тощо), стосунки з іншими (наявність друзів, референтного оточення), когнітивні аспекти (задоволеність власним життям, розчарування в житті), емоційні аспекти (напруженість, чутливість, депресія, зміни настрою тощо). Результати: у процесі емпіричного дослідження були визначені низькі показники суб’єктивного благополуччя студентів, що засвідчило нагальну потребу в розробленні та реалізації психологічної програми покращення характеристик відчуття суб’єктивного благополуччя. Упровадження тренінгової програми засвідчило її ефективність.
ПСИХОДИНАМІЧНИЙ ПІДХІД ДО ГЛИБИННОГО ПІЗНАННЯ ПСИХІКИ З ВИКОРИСТАННЯМ ПСИХОМАЛЮНКІВ
Authors: Галушко Любов Ярославівна , Євтушенко Ірина Володимирівна , Ткаченко Катерина В’ячеславівна , Сергата Інеса Олегівна , Бульченко Дмитро Володимирович
Published: April 2024

У статті стверджується, що використання у процесі функціонування груп активного соціально-психологічного пізнання (АСПП) візуалізованої самопрезентації психіки (за тематичної її диференціації) актуалізує дієвість пралогічного мислення. Вищесказане виявляється не лише в тому, що кожна людина (без винятку) легко візуалізує психіку, крізь призму тематичних психомалюнків, як і впорядковує їх послідовність для психоаналізу. У статті стверджується, що таке впорядкування є підлеглим механізму партиципації. Практика засвідчує, що немає різниці, чи підібрані малюнки з наявних, чи намальовані власноруч. Кожна людина здатна бездоганно впорядкувати послідовність психомалюнків для їх аналізу (ранжувати за їхньою психологічною значущістю). Респондент візуалізує психіку згідно з тематикою психомалюнків. Зміст статті доводить ефективність глибинного пізнання психіки за умов її тематичної візуалізації. У статті презентовано оновлений варіант «Моделі внутрішньої динаміки психіки» з доповненням її категорією «Зверх-Ід». Остання є значущим відкриттям у форматі розуміння сутності психодинамічної парадигми, яка стосується закономірності відступів від реальності земного світу у психомалюнках. У статті доведено активність впливу на психіку ще доедіпального періоду розвитку психіки, поза підкореністю «принципу реальності». У статті наводиться відповідний емпіричний матеріал, який доводить вплив на психіку сучасної людини архаїчного спадку, який не є підлеглим «принципу реальності». Емпіричний багаж статті доводить той факт, що візуалізована самопрезентація учасників групи активного соціально-психологічного пізнання є вкрай необхідною передумовою глибинного пізнання психіки.
IMPLEMENTASI PROGRAM PENYEDIAAN AIR MINUM DAN SANITASI BERBASIS MASYARAKAT (PAMSIMAS) DI DESA NOEBAUN KECAMATAN NOEMUTI KABUPATEN TIMOR TENGAH UTARA
Authors: Tiza Agustinus Longa , Bifel Maria Stefany , Minggu Pionisius
Published: April 2024

Penelitian ini berjudul Implementasi Program Penyediaan Air Minum dan Sanitasi Berbasis Masyarakat (PAMSIMAS) di Desa Noebaun Kecamatan Noemuti. Permasalahan utama yang ditemui dalam penelitian ini adalah Program Pamsimas belum sepenuhnya dirasakan mafaatnya oleh masyarakat Desa Noebaun. Hal in ditandai dengan belum tercapainya target yang ditetapkan dalam program Pamsimas dalam pemenuhuan kebutuhan air bersih bagi masyarakat. Tujuan penelitian ini adalah untuk menganalisis dan mendeskripsikan implementasi program Pamsimas di Desa Noebaun. Metode yang digunakan adalah kualitatif. Hasil penelitian menunjukan  bahwa Implementasi Program Pamsimas di Desa Noebau Kecamatan Noemuti cukup berhasil baik ditinjau dari pemanfaatan sumberdaya. Komunikasi yang ada dalam pelaksanaan Program Pamsimas cukup baik baik dilihat dari saluran komunikasi yang ada, dan kecenderungan individu bersikap positif dan partisipatif dalam mendukung pelaksanaan program Pamsimas. Hal-hal yang mendukung adalah komunikasi yang berjalan baik, tanggapan masyarakat yang baik dan partisipatisipatif, pemberdayaan sumber daya yang optimal baik SDM, kewenangan maupun informasi yang ada. Hal-hal yang menghambat pelaksanaan Program Pamsimas antara lain berkaitan dengan kelangkaan sumber air baku untuk air bersih, keterbatasan pendelegasian kewenangan yang diberikan pemerintah pusat terhadap pelaksana di lapangan. Disisi lain, profesionalisme kerja para pelaku program belum otimal.
URBAN PLANNING FACTORS OF LAND USE MONITORING OF UNITED TERRITORIAL COMMUNITIES
Authors: Kanivets O. , Goi V.
Published: April 2024

There is proof that in the conditions of ensuring transformational processes, issues of formation and use of land and increasing the efficiency of their use at the local level arise. In addition, the presented processes deepen because of the reform of local self-government, which ensures the effectiveness and interaction of stakeholders. The core element in developing these relationships is the united territorial communities and land use directions and features, with consideration of the influence of factors. In the system of land relations of united territorial communities, urban planning factors that influence the development and implementation of modern monitoring tools are particularly important.
The study aims to determine the urban planning factors of land use monitoring of united territorial communities. To achieve the goal, we solved the following tasks: characterisation of urban planning factors of land use monitoring and highlighting the peculiarities of the formation of urban planning factors of land use of united territorial communities. Among the peculiarities of the development of land use monitoring of united territorial communities is also the identification of a system of urban planning factors, namely the levels: development and implementation of land management projects regarding the arrangement of territories for urban planning needs; formation and application of the urban development support system; development and implementation of monitoring procedures of urban planning activities; formation and use of urban cadastre; provision of architectural and construction control; development and implementation of comprehensive plans; change in the level of construction activity in united territorial communities.
We have formed local factors of urban planning support for land use monitoring of united territorial communities, with most of them determined by qualitative methods. Estimating the indicator of the change in the level of construction activity in the united territorial communities uses quantitative methods. It creates a basis for implementing monitoring procedures through the application of urban planning provision of land use of united territorial communities.
Keywords: urban planning factors, land use, united territorial communities, monitoring.
INTERNATIONAL PRACTICE AND STANDARDS OF LAND VALUATION AND THEIR IMPACT ON THE LAND PLOTS MARKET PRICE
Authors: Udovenko I. , Goi V. , Khariv V.
Published: April 2024

The article analyses international practices and land valuation standards, highlighting their significance in forming market prices for land plots. The authors consider the importance of harmonising national valuation standards with international ones, which will be an essential step toward ensuring transparency, fairness, and efficiency in the land market. The focus is on the impact of internationally recognised standards such as IVS, RICS, and TEGoVA on the land pricing process in different countries. The article discusses in detail the mechanisms through which standardised evaluation methods contribute to increasing the investment attractiveness of land resources, strengthening the confidence of investors and land owners, and improving the legal and economic basis of the land market. The authors emphasise that an adequate assessment of the land that meets international standards is critical for ensuring effective management of land resources, conducting sustainable land use, and preserving the ecological balance. The study reveals the potential advantages and challenges of adopting international assessment standards in Ukraine. In particular, we consider the issues of the need for retraining appraisers, the adaptation of national legislation and regulatory framework, and the potential for increasing transparency and stabilisation of the land market. The article points out the importance of international cooperation and exchange of experience for the successful integration of Ukraine into global market relations, boosting its investment attractiveness and fostering the sustainable development of land resources. The article provides a valuable contribution to understanding the main aspects of international experience in land valuation and its impact on market price formation mechanisms. It calls for further research and discussion of ways to adapt and implement international standards in Ukraine as a necessary prerequisite for developing an open, fair, and efficient land market. The study significantly contributes to the scientific understanding of the harmonisation processes of national approaches to land valuation with international standards and practices, which is relevant in the context of globalisation and market integration.
Keywords: international valuation standard, land value, land plot, land cadastre.
A METHODOLOGY FOR DETERMINING RISKS BASED ON THE ANALYSIS OF INJURIES TO EMPLOYEES OF INDUSTRIAL ENTERPRISES
Authors: Petrenko I. , Chencheva O. , Zozulia S. , Shevchenko V. , Lohvinkov S.
Published: April 2024

The article aims to analyse the causes of occupational injuries, identify risk factors for employees, and improve workplace safety and accident prevention standards. To achieve the stated aim, the authors applied a comprehensive approach, which included an in-depth study of recent injury trends, identification of the main causal factors, and a thorough examination of the risks affecting working conditions and leading to injuries. The research methodology included a variety of tools, such as a deep analysis of statistical data on injuries in the context of an industrial enterprise, a review of internal documentation, and an evaluation of risk factors. The study results provided a detailed picture of the changing trajectory of injuries among industrial workers, which is closely related to their length of service and experience at the enterprise. Based on this understanding, we derived a specific risk assessment formula that synthesised the relationship between injuries and length of service. In addition, a thorough analysis of the structure of injuries during different shifts revealed a pronounced tendency for accidents to occur in the evening and at night, partly due to the psychological and physiological stress experienced by employees during these periods and the impact of microclimatic working conditions. To enhance the effectiveness of the risk assessment methodology, we proposed to integrate a comfort factor coefficient that shows the microclimatic factors’ impact on occupational safety and injury rates. These efforts have resulted in an improved risk assessment formula that can provide a more accurate prognosis of injury incidents and help optimise occupational health and safety protocols for employees at industrial enterprises. In addition, using statistical data, the study determined the cause-effect relation between risks to industrial workers, shown through the visual representation of an Ishikawa diagram, thus providing a further perspective for risk assessment in the enterprise.
Keywords: injuries, risks, injury analysis, mining and processing plant, industry.
Initial Investigation of the Potential of Robusta Coffee, Arabica Coffee, and Caffeine in Asthma Treatment through the Evaluation of 5-Lipoxygenase Inhibition Activity
Authors: Yuniarta Tegar Achsendo , Handayani Rosita
Published: April 2024

Numerous studies have documented the potential of coffee to aid in asthma prevention. Nevertheless, research into how coffee influences asthma management has not been available. One known mechanism by which asthma medications work involves inhibiting 5-lipoxygenase (5-LOX) activity. This study aims to determine the potency of Coffea canephora var. Robusta extract (CRE), Coffea arabica extract (CAE), and caffeine are the primary isolates against 5-LOX activity. Extraction was performed by a reflux procedure using 96% ethanol with a sample-total solvent ratio of 1 : 10, an extraction time of 1 hour, and the extraction was conducted in triplicate. Fractionation was carried out by liquid-liquid partition using a chloroform-water system. Caffeine further purification was performed by the sublimation method, and the inhibition of 5-LOX activity was evaluated using the spectrophotometric method at λ = 234 nm. Apigenin was used as a positive control. From the experiment conducted, the IC50 of the CRE, CAE, caffeine, and apigenin against 5-LOX was 32.2 ± 1.4, 42.1 ± 2.3, 14.3 ± 1.6, and 7.4 ± 1.7 µg/mL, respectively. Continued efforts to isolate bioactive compounds from coffee extract led to the discovery of caffeine, which exhibited a more potent inhibitory effect on 5-LOX. The inhibition of 5-LOX activity by caffeine occurs in a non-competitive manner.
Genetic CYP2A6 Polymorphism May Worsen Glycohemoglobin Levels: Study among Javanese Indonesian Smokers
Authors: Patramurti Christine , Virginia Dita Maria
Published: April 2024

We have examined the inactive CYP2A6 alleles gene, including CYP2A6*4, CYP2A6*7, and CYP2A6*9, associated with glycohemoglobin levels among Javanese Indonesian smokers. There are 106 smokers participating in this study. Due to the number of cigarettes smoked per day, there are three groups of smokers: light, intermediate, and heavy smokers, with 98.7% being light and intermediated smokers while the rest are heavy smokers. All participants had smoked for more than 10 years, indicating they had been exposed to nicotine for a long time. Based on their genotype, there were four groups of smokers, including fast, intermediate, slow, and poor metabolizers. Most fast and intermediate metabolizers have HbA1c levels in the normal range (<5.7). On the other hand, most slow metabolizers have Hb1c levels >5.7, and all fast metabolizers have HbA1c levels >5,7, indicating that they the prediabetes and diabetes. The chi-square test showed a relationship between CYP2A6 polymorphism and HbA1c levels among the participants (P-value 0.000 <0.005 and χ2=54.6, df=1). The presence of an inactive allele will worsen the HbA1c levels in smokers.
Marine Sponge Xestospongia sp.: A Promising Source for Tuberculosis Drug Development - Computational Insights into Mycobactin Biosynthesis Inhibition
Authors: Arfan Arfan , Asnawi Aiyi , Aman La Ode
Published: April 2024

Mycobacterium tuberculosis (MTB) remains the leading cause of infection, with a significant fatality rate, owing primarily to drug resistance. MTB contains the enzyme salicylate synthase, which regulates mycobactin production to bind iron ions from the host cell, facilitating the bacteria to grow and reproduce. This study investigates the potential of marine sponges to inhibit the MTB salicylate synthase by exploiting a computational approach combining molecular docking and dynamics simulations. Forty-six compounds from Xestospongia sp. were chosen from the Marine Natural Products database. The docking results selected four compounds (CMNPD15071, CMNPD7640, CMNPD26706, and CMNPD7639) from this sponge, which provide more negative binding energy than their inhibitors (RVE). After reclassifying their interactions, such as hydrophobic and hydrogen bonds, CMNPD15071 (Sulfuric acid mono-(8-methoxy-12b-methyl-6-oxo-2,3,6,12b-tetrahydro-1H-5-oxa-benzo[k]acephenanthrylen-11-yl) ester) and CMNPD7640 (secoadociaquinone B) performed molecular dynamics simulations to assess their stability. These two compounds show a promising stability profile compared to RVE based on RMSD, RMSF, SASA, and gyration analysis. Furthermore, the binding affinity prediction of these two compounds using the MM/GBSA calculation method reveals that CMNPD15071 (-38.48 kJ/mol) had the highest affinity for binding to MTB salicylate synthase compared to RVE (-35.36 kJ/mol) and CMNPD7640 (-26.03 kJ/mol). These findings demonstrate that compounds from Xestospongia sp. can block MTB mycobactin biosynthesis by inhibiting salicylate synthase.
Nanoemulsion Mouthwash Formulation of Bajakah Tampala (Spatholobus littoralis Hassk.) Skin Extract Against Candida albicans
Authors: Hamzah Hasyrul , Gunawan Dede Reza , Pratiwi Sylvia Utami Tunjung , Bakhtiar Muh. Irham , Pratama Virgiawan Yoga , Subhan Muhammad , Maulana Riza
Published: April 2024

Candida albicans can cause two infections in humans: superficial and systemic. The ability of C. albicans to infect the host is influenced by virulence factors and character changes so that it can fool the immune system. From the character change factor, C. albicans can form a biofilm. This study aims to determine the good concentration in inhibiting and determine the antifungal and antibiofilm activity of nanoemulsion mouthwash formulation of bajakah tampala (Spatholobus littoralis Hassk) skin extract against C. albicans. This research was conducted with an experimental method. The formulation used a spontaneous magnetic stirrer technique to make nanoemulsion preparations. Antifungal and antibiofilm tests were carried out by dilution method using a 96-well plate and a microplate reader with a wavelength of 620 nm to determine the percentage inhibition against C. albicans and determine MIC50 and MBIC50. The results showed that the nanoemulsion mouthwash formulation of S. littoralis inhibited the planktonic and biofilm of C. albicans. The concentration of 1% is expressed as MIC50 and MBIC50. Therefore, the nanoemulsion formulation of S. littoralis extract could inhibit the growth of C. albicans in the oral cavity.
Potential of Indonesian Plants as Polymicrobial Anti-Biofilm
Authors: Sari Rafika , Pratiwi Sylvia Utami Tunjung , Murti Yosi Bayu , Damayanti Ema
Published: April 2024

Biofilm infection occurs in 80% of chronic infections caused by 60% of biofilms from plankton cells and polymicrobial biofilms. Due to synergistic interactions between species, infections caused by polymicrobial biofilms are more virulent than monospecies biofilm infections. New anti-biofilm candidates are constantly being developed by tracing the content of active compounds from medicinal plants native to Indonesia. The need to find new plant sources that have the potential as anti-biofilms is increasingly needed along with increasing microbial resistance. Various studies show that active compounds that have anti-biofilm potential are polyphenols, quercetin, curcumin, gallic acid, and ferulic acid. The mechanism of action of anti-biofilms is through the prevention of attachment and formation of biofilms, inhibition of quorum sensing, and inhibition of gene expression in microbes.
Comparative Phytochemical Profiling and Biological Activities in the Flowers and Stalks of Tulbaghia violacea
Authors: Maleka Gontse , Oyerinde Rebecca Opeyemi , Risenga Ida Masana
Published: April 2024

Tulbaghia violacea is indigenous to Southern Africa and has been used extensively in traditional medicine in this region. Extensive research has been documented on the bioactive compounds found in the leaves and roots but not in the flowers and stalks. Thus, this study assessed the phytochemical profile and biological activities in the flowers and stalks of T. violacea. Methanolic and aqueous extracts of the air and freeze-dried T. violacea were screened for phytochemicals, and then antioxidant and antibacterial assays were performed. Phytochemicals such as phenols, tannins, flavonoids, coumarins, and terpenoids are present in either of the tested plant parts. The flowers contain most of the phytochemicals being tested and a higher total phenolic, tannin, and proanthocyanidin content than the stalks. The flowers exhibit the strongest scavenging activity against 2,2-diphenylpicryhydrazyl radicals and metal oxidants. The hydrogen peroxide scavenging activities show that the aqueous flower extracts have a higher radical scavenging activity than stalks. In contrast, the methanolic stalk extracts have a higher antioxidant activity than the flowers. Antibacterial activity is only exhibited in the flowers, showing resistant and intermediate inhibition zones of Escherichia coli and Staphylococcus aureus growth, respectively. This study validates the use of T. violacea in traditional medicine, and these results are significant for conserving the species as specific plant parts can be harvested to treat specific ailments. This study suggests the potential application of T. violacea, particularly the flowers and stalks, in the pharmaceutical and cosmetic sectors.
Development and Validation of a Questionnaire for the Assessment of the Factors that Influence ADR Reporting by Pharmacists
Authors: Firdaus Favian Rafif , Nita Yunita , Setiawan Catur Dian , Zairina Elida
Published: April 2024

Drug safety is a significant concern in many countries, as side effects (AE) and adverse drug reactions (ADR) have caused many deaths worldwide. One of the reasons is the low contribution of pharmacists in spontaneously reporting AE/ADR. This study aims to develop a questionnaire to assess factors that correlate with spontaneous reporting by pharmacists. A questionnaire pilot was tested on 30 pharmacist respondents who worked in type C hospitals in Surabaya and Sidoarjo, Indonesia. Respondents' responses were then evaluated for face validity, construct validity, and reliability. The results showed that the face validity of the questionnaire was ideal. Then, the results of the construct validity of the knowledge section using point biserial correlation showed that two items were invalid because the r-value was smaller than the r-table (r = 0.361). Then, construct validity uses the factor analysis method for psychological, environmental, and practical variables by paying attention to the Kaiser-Mayer-Olkin Measure (KMO) value, which must be greater than 0.5, the significance of the Bartlett test, which must be less than 0.05 and the factor loading value which conditions must be greater than 0.5. As a result, most of the psychological, environmental, and practical variables show valid and reliable results. However, further consideration should be given to eliminating some items that do not meet the requirements. In conclusion, this validated questionnaire can be used to obtain additional information regarding factors influencing spontaneous reporting by pharmacists.
Penerapan Metode Servqual Dan Customer Satisfaction Index (CSI) Untuk Peningkatan Kepuasan Pengguna Light Rail Transit (LRT) Di Kota Palembang
Authors: Sahfitri Vivi , Suyanto Suyanto , Dayi Dayang
Published: April 2024

One mode of mass transportation that is currently widely used by the people of Palembang City is Light Rail Transit (LRT). This research aims to determine the level of satisfaction of LRT mass transportation users in Palembang City using the ServQual method and the CSI method. Measuring the level of satisfaction uses 5 dimensions, namely Tangible, Reliability, Responsiveness, Assurance and Empathy. Measurements using the ServQual Method overall show that the level of satisfaction with the quality of service on the LRT in Palembang city is 0.908552, which is close to a value of 1, so it can be concluded that users are very satisfied with the quality of service on the LRT in Palembang city. However, based on the Gap obtained from Satisfaction and Expectations, each attribute in the 5 dimensions of service quality has a Negative Gap value which indicates that improvements still need to be made to increase user satisfaction in the future. Measuring the level of satisfaction using the CSI method obtained an LRT user satisfaction level index of 0.7659 in the range of 0.60 – 0.80, which means the satisfaction index for LRT mass transportation services is in the Satisfaction criteria
Russia as a Civilization-State: Making Sense of Moscow’s 2023 Foreign Policy Concept
Authors: Ayar Başaran
Published: April 2024

With the war against Ukraine, Russian foreign policy is going through a critical juncture that causes significant regional and global uncertainties. The current crisis is not a result of short-term brinkmanship but a consequence of Moscow’s three-decade-long search for self-identification since the collapse of the Soviet Union. To follow the Kremlin’s overall foreign policy trajectory and self-identification, Foreign Policy Concepts are quite helpful since they reflect the main framework of Russian diplomacy since 1993. The study begins by explaining the significance of the Concepts for Moscow’s foreign policy. Then, it highlights the main themes of the latest Foreign Policy Concept: anti-hegemonism, multipolarity, Russia as a centre, and Russia as a civilization-state. In each section, Moscow’s understanding of these themes is discussed and put into a historical context to explain the significance of their appearance in the official documents. The article then compares the previous concept to expose the change of narrative in 2023 to show the main changes in Russia’s foreign policy priorities, articulation of other actors, and perception of threats.
Technology impact on postpartum culture implementation: Javanese and Chinese culture
Authors: Amanda Angelina , Susilo Greysia , Izzati Alifia Wida
Published: April 2024

After giving birth, maternal care still continues. Keeping tabs on women’s mental well-being is crucial for creating a conducive surrounding needed for both the mother and her baby. Neglecting the mother’s emotional health can produce certain negative side effects starting from Baby Blues (postpartum depression) to the extent of physical bleeding. Consequently, these side effects need to be mitigated by society adopting the proper knowledge on the matter. Sadly, today’s practice of treating mothers during this period may differ due to cultural varieties across nations. Indonesia is home to thousands of cultures, that being said, Javanese and Chinese are two ethnicities that populate Java Island. Both have their ways of caring for mothers during postpartum. However, many cultural practices have been concluded to be misconduct in the mother’s care. Among many mistreatments, the urge to be completely immobile is still encouraged in these two cultures along with some irrational taboos. In the dawn of Internet of Things (IoT), mothers can benefit from the use of technology. AI has the potential to be an epoch-making development in maternal care. By utilizing researched medical findings and interviews, it is found that AI can help to alternate society’s belief towards old postpartum care traditions.
Feasibility analysis of the neocaridina ornamental shrimp cultivation business in Gunung Mulya Village, Tenjolaya District, Bogor Regency
Authors: Kusmiati Kusmiati , Hardini Sri Yuniati Putri Koes
Published: April 2024

Currently, fish farming activities are carried out not only to meet people's consumption needs, but many farmers also use the waters to cultivate ornamental shrimp, one of which is the freshwater ornamental shrimp type Neocaridina. This research was conducted in Gunung Mulya Village, Tenjolaya District, Bogor Regency. This research aims to determine innovation and technical cultivation as well as the feasibility of cultivating freshwater ornamental shrimp of the Neocaridina type in Gunung Mulya Village, Tenjolaya District, Bogor Regency, which includes identifying costs, revenues, profits, and business feasibility. The research method used in data collection is quantitative methods to identify costs, revenues, profits, and business feasibility, which aim to determine whether or not the freshwater ornamental shrimp cultivation business in Gunung Mulya village, Tenjolaya subdistrict, Bogor Regency, is feasible to run. Based on the results of the data analysis, it was concluded that cultivating freshwater ornamental shrimp of the Neocaridina type in Gunung Mulya village, Tenjolaya subdistrict, Bogor Regency, was profitable, with the total profit obtained in 1 production cycle being IDR. 15,413,334. The financial aspects of business feasibility indicators obtained show an R/C ratio of 2.60 and a B/C ratio of 1.60. Thus, the freshwater ornamental shrimp cultivation business in Gunung Mulya Village, Tenjolaya subdistrict, Bogor Regency, is feasible. This research provides insight into the techniques and innovations used in cultivating Neocaridina ornamental shrimp.
Chemical characteristics of meat analog from sorghum, oyster mushroom, and red bean
Authors: Zahira Afrida , Andayani Relita Anggun , Anggraeni Dinar Ainahaque , Radiansyah Mohamad Rajih , Hakiki Dini Nur
Published: April 2024

Food security is a challenge faced by emerging countries such as Indonesia. One of the solutions is food diversification by developing meat analogs or meat substitutes, which are plant-derived food products typically processed to mimic the flavor, texture, and appearance of meat. Meat and animal-based food products are generally related to environmental threats like global greenhouse gases. Excessive red and processed meat consumption have also been identified as risk factors. Therefore, developing meat analogs from plant-based ingredients has advantages in creating a diverse, balanced, and healthy substitute. This study aims to determine the chemical characteristics of meat analogs from sorghum, oyster mushroom, and red bean. This research consisted of 4 treatments with the ratio of sorghum, oyster mushroom, and red bean (%): P1 (20:55:25), P2 (15:65:20), P3 (10:75:15), and P4 (5:85:10). Meat analog was analyzed such as water content, ash, fat, protein, carbohydrate, fiber, and Fe content. The results showed that the best treatment for physicochemical characteristics was P1 (20% sorghum:55% oyster mushroom:25% red bean), which contained fiber 3.99%, ash 0.90%, protein 7.02%, carbohydrate 42.34%, fat 1.35%, water 43.13%, and Fe 21.81%.
effect of adding suji leaf flour on the physical characteristics of gluten-free cookies
Authors: Anugrah Naufal Permata , Sukma Rahayu , Niza Nadhifatun , Christiana Mareta Ester , Vionita Vionita , Rismaya Rina
Published: April 2024

Modern society is now increasingly paying attention to the food it consumes. Cookies, which are generally made from wheat, are now starting to be developed into non-gluten products from local flour which are considered healthier. This research aims to determine the effect of adding suji leaf flour on the physical characteristics of cookies. The method used in this research was a completely random plan with different concentrations of suji leaf powder, namely 0%, 2%, 4%, 6%, 8%. The physical parameters measured are texture (hardness and slice ability). The results of the research showed that the concentration of added suji leaf powder had a significant effect on the hardness and slicing power of the cookies produced. The higher the addition of suji leaf flour, the higher the measured hardness and slicing power values of the cookies. Control cookies without the addition of suji leaf flour had the lowest hardness and slicing power values (622.25 gf and 973.50 gs) and cookies with 8% addition of suji flour had the highest hardness and slicing power (1040.77 gf and 4807.67 gs). In conclusion, the addition of suji leaf flour to cake formulas provides new insights for developing healthier cakes from local ingredients.
A murine model of peanut-allergic asthma
Authors: Paolucci Marta , Antz Nathalie , Homère Valentine , Kolm Isabel , Kündig Thomas M. , Johansen Pål
Published: April 2024

Objectives

Peanut allergy is an IgE-mediated food allergy that is associated with asthma in certain patients. With increasing prevalence, its great impact on the quality of life, and a lack of treatment options, the need for new therapy options is a given. Hence, models for research and development are required. This study aimed to establish a murine model of allergic airway inflammation induced by peanut allergens.

Methods

C3H mice were sensitised by intraperitoneal injections of peanut allergen extract and challenged by an intranasal application of the same extract. The assessment of airway inflammation involved the analysis of immune cells in the bronchoalveolar lavage fluid as measured by flow cytometry. Inflammatory reactions in the lung tissue were also studied by histology and quantitative PCR. Moreover, peanut-specific immune responses were studied after re-stimulation of spleen cells in vitro.

Results

Sensitisation led to allergen-specific IgE, IgA, and IgG1 seroconversion. Subsequent nasal exposure led to allergic airway inflammation as manifested by structural changes such as bronchial smooth muscle hypertrophy, mucus cell hyperplasia, infiltration of eosinophil cells and T cells, as well as an upregulation of genes expressing IL-4, IL-5, IL-13, and IFN-γ. Upon re-stimulation of splenocytes with peanut allergen, increased secretion of both T-helper type 2 (Th2) and Th1 cytokines was observed.

Conclusion

We successfully established a peanut-associated asthma model that exhibited many features characteristic of airway inflammation in human patients with allergic asthma. The model holds potential as a tool for investigating novel therapeutic approaches aimed at preventing the development of allergic asthma.
A review of hydrazide-hydrazone metal complexes’ antitumor potential
Authors: Ribeiro Nádia , Correia Isabel
Published: April 2024

Cancer inflicts a tremendous burden on modern society, and more effective and selective treatments need to be developed. Metallodrugs have been extensively explored as alternatives to current chemotherapeutic regimens that suffer from shortcomings such as severe side effects and acquired resistance. Hydrazide-hydrazones are a family of organic molecules containing the hydrazone functionality attached to a carbonyl group (−C=N−NH−CO). These molecules are extremely versatile and can be obtained from modular reactions between hydrazides and aldehydes or ketones, of which a large library is commercially available. Hydrazide-hydrazones show numerous therapeutic effects, and typically, their metal complexes exhibit increased potency. This review aims to highlight the potential of hydrazide-hydrazone metal complexes in the field of anticancer research. It focuses on the literature published in the last 10 years (2013-2023) and describes their biological effects, their antiproliferative activity and their mechanisms of action. It is organized by metal ion, including Cu, Ru, Pt, Pd, V, other d-block, lanthanide, and Ga and Sn ions. It highlights the diversity of molecules being developed and can be used as a guide for developing new hydrazide–hydrazones as efficient anticancer agents.
Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome
Authors: Gordon Leslie B. , Basso Sammy , Maestranzi Justine , Aikawa Elena , Clift Cassandra L. , Cammardella Antonio Giovanni , Danesi Tommaso Hinna , del Nido Pedro J. , Edelman Elazer R. , Hamdy Abeer , Hegde Sheila M. , Kleinman Monica E. , Maschietto Nicola , Mehra Mandeep R. , Mukundan Srinivasan , Musumeci Francesco , Russo Marco , Rybicki Frank J. , Shah Pinak Bipin , Suarez William A. , Tuminelli Kelsey , Zaleski Katherine , Prakash Ashwin , Gerhard-Herman Marie
Published: April 2024

Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare genetic premature aging disease that is historically fatal in teenage years, secondary to severe accelerated atherosclerosis. The only approved treatment is the farnesyltransferase inhibitor lonafarnib, which improves vascular structure and function, extending average untreated lifespan of 14.5 years by 4.3 years (30%). With this longer lifespan, calcific aortic stenosis (AS) was identified as an emerging critical risk factor for cardiac death in older patients. Intervention to relieve critical AS has the potential for immediate improvement in healthspan and lifespan. However, HGPS patient-device size mismatch, pervasive peripheral arterial disease, skin and bone abnormalities, and lifelong failure to thrive present unique challenges to intervention. An international group of experts in HGPS, pediatric and adult cardiology, cardiac surgery, and pediatric critical care convened to identify strategies for successful treatment. Candidate procedures were evaluated by in-depth examination of 4 cases that typify HGPS clinical pathology. Modified transcatheter aortic valve replacement (TAVR) and left ventricular Apico-Aortic Conduit (AAC) placement were deemed high risk but viable options. Two cases received TAVR and 2 received AAC post-summit. Three were successful and 1 patient died perioperatively due to cardiovascular disease severity, highlighting the importance of intervention timing and comparative risk stratification. These breakthrough interventions for treating critical aortic stenosis in HGPS patients could rewrite the current clinical perspective on disease course by greatly improving late-stage quality of life and increasing lifespan. Expanding worldwide medical and surgical competency for this ultra-rare disease through expert information-sharing could have high impact on treatment success.
Evaluation of the relationship between left atrial stiffness, left ventricular stiffness, and left atrioventricular coupling index in type 2 diabetes patients: a speckle tracking echocardiography study
Authors: Dang Hai Nguyen Ngoc , Luong Thang Viet , Ho Binh Anh
Published: April 2024

Background

Cardiovascular complications are a leading cause of mortality and disability in individuals with diabetes mellitus (DM). Moreover, DM can directly impact the structure and function of cardiac muscle. We conducted a study to evaluate cardiac stiffness in DM patients in both the left atrium (LA) and left ventricle (LV), as well as to assess the impact of DM on the synchronization of the LA and LV, particularly within the Vietnamese population, utilizing speckle tracking echocardiography (STE).

Methods

We studied 111 research subjects divided into two groups comprising 52 patients with DM and 59 healthy individuals. All the subjects provided relevant clinical information, and echocardiography was performed to assess the indices of LA stiffness, LV stiffness, and left atrioventricular coupling index (LACI).

Results

Our study indicated that DM patients exhibited greater LA and LV stiffness than control patients. The LACI (%) in the DM group was also greater than that in the control group (17.12% ± 6.72% vs. 12.28% ± 3.96%, respectively; p < 0.001). The LACI was positively correlated with the LA and LV stiffness indices. Decreased levels of LV GLS, adjusted for age, sex, blood pressure, and BMI, have emerged as identified risk factors for DM.

Conclusions

LA stiffness, LV stiffness, and the LACI are greater in DM patients than in normal individuals.
Electromagnetic based flexible bioelectronics and its applications
Authors: Pan Shenyi , Zhou Minghao , Liu Longyin , Shen Huimin
Published: April 2024

With the increasing demand in seamless interface between artificial devices and biological structures, flexible bioelectronics has been developed rapidly in recent years. Compared with traditional rigid bioelectronics, flexible devices are more adaptable to the integration for various parts both inside and outside of the organism. Significant achievements have been made in biomedical devices, neuroelectronics and wearable devices. With the development of flexible bioelectronics, electromagnetics is becoming a crucial part in signal interference reduction and information transmission or feedback, taking advantages of strong penetration and rapid response in a variety of biological materials. In this review, we focus on the latest developments in electromagnetic based flexible bioelectronics, involving materials, sensation, seamless integration, and power supply, as well as the latest achievements in the fields of external wearables, internal implants, soft robotics and drug delivery system. Based on these, the main challenges facing flexible bioelectronics, are analyzed, including stretchability caused by mismatch between mechanical properties of soft and hard components, biocompatibility, environmental stability, to facilitate the further development of flexible bioelectronics.
Low TSH and low T3 hormone levels as a prognostic for mortality in COVID-19 intensive care patients
Authors: Sror-Turkel Or , El-Khatib Nidal , Sharabi-Nov Adi , Avraham Yaniv , Merchavy Shlomo
Published: April 2024

Introduction

Coronavirus diasease 2019 (COVID-19) can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. The thyroid gland is a neuroendocrine organ that plays an important role in regulating immunity and metabolism. Low serum levels of thyroid hormones are common in critical disease situations. The association between low thyroid hormone levels and mortality in COVID-19 intensive care patients has yet to be studied.

Aim

The aim of this study is to compare thyroid hormone levels between patients in the general intensive care unit (ICU) to patients in the COVID-19 ICU.

Methods

This was a retrospective comparative study of 210 patients who were hospitalized at Ziv Medical Center in the general ICU and in the COVID-19 ICU. Clinical and demographic data were collected from patient’s electronic medical records.

Results

Serum thyroid hormone levels of Thyroid Simulating Hormone (TSH), T4, and T3 were significantly lower in COVID-19 intensive care unit patients compared to the patients from the general intensive care unit (p < 0.05). The mortality rate in the COVID-19 ICU (44.4%) was higher compared to that in the general ICU (27.3%) (p < 0.05). No significant statistical difference was observed between the two groups in terms of gender and recorded comorbidities of diabetes mellitus, cerebral vascular accident, kidney disease, and cancer.

Conclusions

Low serum thyroid hormone levels—T3, T4, and TSH—in COVID-19 ICU patients are associated with higher mortality and could possibly be used as a prognostic factor for mortality among COVID-19 ICU patients. Thyroid hormone levels should be a part in the routine evaluation of COVID-19 ICU patients.