bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Serum Interleukin-17 and Interleukin-23 Levels with
Disease Activity, Function, Mobility, Enthesitis Index in Patients with
Ankylosing Spondylitis
Authors: Beyazal Münevver Serdaroğlu , Tayfun Aliekber , Devrimsel Gul , Yıldırım Murat , Arpa Medeni
Published: November 2022

Aim: More and more studies have demonstrated that the interleukin
(IL)-23/IL-17 axis is highly associated with immune dysfunction and
activated autoimmune inflammation. The purposes of this study were to determine
the serum levels of IL-17 and IL-23 in ankylosing spondylitis (AS) patients
compared with healthy controls and evaluate these cytokine levels based on
disease-related characteristics. Material and Methods: Eighty-six consecutive AS
patients and 70 sex and age-matched healthy controls were included in the study.
The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Ankylosing
Spondylitis Disease Activity Score (ASDAS)-erythrocyte sedimentation rate (ESR),
ASDAS-C reactive protein, the Bath Ankylosing Spondylitis Functional Index
(BASFI), the Spondyloarthritis Research Consortium of Canada (SPARCC) enthesitis
index, the Bath Ankylosing Spondylitis Metrology Index (BASMI), the Ankylosing
Spondylitis Quality of Life Questionnaire (ASQoL) and Achilles pain VAS scores
were recorded. Serum IL-17 and IL-23 levels were examined by enzyme-linked
immunosorbent assay. Results: The serum levels of IL-17, IL-23 and CRP as well
as ESR values were significantly increased in AS patients compared with controls
(1.94 vs. 0.28 pg/mL p ˂ 0.001; 82.9 vs.
44.3 pg/mL p ˂ 0.001; 0.48 vs.
0.30 mg/dL, p=0.001; 12±13.9 vs.
8±6.8 mm/h, p=0.003, respectively). In AS
patients, serum IL-17 levels were significantly correlated with the ASDAS-ESR
and ASDAS-CRP (r=0.244, p=0.024; r=0.258,
p=0.017), but not with ESR, CRP, BASDAI, function, mobility, quality of
life, enthesitis index or Achilles pain scores (all p>0.05). Serum IL-23
levels demonstrated a significant correlation with Achilles pain VAS, but not
with other disease-related parameters (all p>0.05). Conclusions: AS
patients had increased serum IL-17 and IL-23 levels compared with healthy
controls, and serum IL-17 levels were associated with disease activity. Our
study results support the hypothesis that the IL17/23 pathway plays an
important role in the pathogenesis of AS.
Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems
Authors: Lorenz Nikolas Johannes , Link Alexander , Czapiewski Piotr , Arnim Ulrike von
Published: November 2022

Background Eosinophilic Esophagitis (EoE) has received increasing attention as a disease entity, and it is now recognized as an important disorder of the Upper Gastrointestinal Tract. Topical corticosteroids (tCS) are effective in clinical-pathological remission induction (RI) and remission maintenance (RM) of active EoE. With scoring systems, such as clinical (SDI), endoscopic (EREFS), and histological (EoEHSS) systems, EoE can be graded, and its disease activity can be assessed.

Objective To discover how closely results within each of the three scoring systems SDI, EREFS, and EoEHSS are correlated between initial diagnosis (ID), RI, and RM, and to determine how well scores from the three systems are intercorrelated at each time point.

Methods Retrospective cohort analysis of patients with active EoE was performed between 2006 and 2020, with follow-up for up to 6 years. SDI, EREFS and EoEHSS scores were recorded at ID, at RI, and in RM. Evaluation employed descriptive statistics, the Friedman test, and Bonferroni-corrected post hoc pairwise comparisons.

Results At RI 29 and at RM 19 EoE patients provided data. Significant correlations were found between EREFS and EoEHSS at RI and in RM. Pairwise comparisons showed significant differences between ID and RI for SDI, for EREFS, and for EoEHSS.

Conclusion The scoring systems tested did not show intercorrelation at ID. Comparison revealed significant differences for SDI, EREFS, and EoEHSS between the systems at ID und RI, but not in RM, during tCS treatment. These results underline the efficacy of tCS (at RI and RM) in the treatment of active EoE.
Zukunftsweisendes Arthrose-Management
Authors: Skou Søren Thorgaard , Roos Ewa M. , Baumbach Linda
Published: November 2022

In Dänemark ist es mit dem GLA:D®-Programm gelungen, wissenschaftlich belegte Empfehlungen für die Physiotherapie von Arthrose-Patienten erfolgreich in die klinische Praxis umzusetzen. Auch andere Länder haben das dänische Patientenmanagement in ihr Gesundheitssystem implementiert. So plant auch Deutschland das GLA:D® Programm einzuführen.
Knorpelschaden am Kniegelenk: operative Behandlungsmöglichkeiten und Rückkehr zum Sport
Authors: Niemeyer Philipp , Bumberger Alexander
Published: November 2022

Die Diagnose „Knorpelschaden am Knie“ weckt schlimme Befürchtungen. Doch dank moderner Operationsverfahren ist für viele Sportler eine Rückkehr zum Sport möglich.
Implementierbarkeit, Praktikabilität und Akzeptanz ambulanter
Psychotherapie für zuhause lebende ältere Menschen mit
Depression und Pflegebedarf – Ergebnisse des Innovationsfondsprojekts
PSY-CARE
Authors: Tegeler Christina , Hoppmann Fee , Demmerle Christina , Gellert Paul , Ludwig Valentina , Kessler Eva-Marie
Published: November 2022

Ziel Zuhause lebende pflegebedürftige ältere Menschen mit
Depression sind psychotherapeutisch massiv unterversorgt. Untersucht wird die
Realisierbarkeit ambulanter Psychotherapie bei der Patientengruppe unter den
Bedingungen der Regelversorgung.

Methode Das Innovationsfonds-Projekt PSY-CARE ist eine in Berlin
angesiedelte pragmatische, randomisiert-kontrollierte Studie zur Untersuchung
von Kurzzeit-Verhaltenstherapie für zuhause lebende Menschen
über 60 Jahren mit Pflegegrad und Depression. Ausgewertet werden
Implementierbarkeit, Praktikabilität und Patientenzufriedenheit.

Ergebnisse Allen 102 in die Interventionsgruppe aufgenommenen Patienten
konnte Psychotherapie vermittelt werden, wovon fast alle Therapien
(92,3%) nur durch Hausbesuche realisierbar waren. Die Patienten waren
überwiegend (83,7%) weitgehend bis sehr zufrieden mit der
Psychotherapie. Die für das Projekt gewonnenen ambulanten
Psychotherapeuten bewerteten Angehörigeneinbezug und interprofessionelle
Zusammenarbeit als hilfreich. Anpassungen des Ausbildungs- und
Vergütungssystems wurden als notwendig erachtet.

Schlussfolgerung Hausbesuche, interprofessioneller Austausch und Arbeit
mit Angehörigen müssen reguläre Elemente ambulanter
Psychotherapie werden. Es bedarf einer speziellen gerontopsychologischen
Qualifikation für Psychotherapeuten.
Maßgeschneidert mit System – Motorisches Lernen
Authors: Huber Martin , Janssen Christina
Published: November 2022

In der Neuroreha gewinnt das Motorische Lernen aufgrund guter Evidenzen immer mehr an Bedeutung. Um es systematisch in die Praxis einbinden zu können, braucht es eine Orientierungshilfe. Christina Janssen und Martin Huber stellen das Lernrad vor, anhand dessen Ergo- und Physiotherapeut*innen die Prinzipien des Motorischen Lernens klientenzentriert und teilhabeorientiert umsetzen können.
London Dispersion-Assisted Low-Temperature Gas Phase Synthesis of Hydrogen Bond-Inserted Complexes
Authors: Suhm Martin A. , Lange Manuel , Sennert Elisabeth
Published: November 2022

Supersonic expansions of organic molecules in helium carrier gas mixtures are used to synthesize model (pre)reactive complexes at low temperature. Whether or not barriers for hydrogen bond rearrangements can be overcome in this collisional process is not well understood. Using the example of alcohols inserting into intramolecular hydrogen bonds of α-hydroxy esters, we explore whether dispersion energy donors can assist the process in a systematic way. Bromo, iodo, and tert-butyl substitution of benzyl alcohol in the para-position is used to show that the insertion process into methyl glycolate is controllable, whereas it is largely avoided for the chiral methyl lactate homologue. Methyl lactate appears to steer the transient chirality of benzyl alcohol derivatives in a uniform direction relative to the lactate handedness for the OH∙∙∙O=C insertion product, as well as for the competing attachment to the hydroxy group of the ester. A simple rule based on the total binding energy in relation to the rearrangement barrier is tentatively proposed to estimate whether the insertion is feasible or not in such molecular complexes during expansion.
Aminium-Radical-Mediated Intermolecular Hydroamination of Nonactivated Olefins
Authors: Wang Fei , Jia Si-Ming , Huang Yi-Hang
Published: November 2022

Aminium radicals are attractive intermediates in synthetic chemistry that readily participate in a series of C–N bond-forming processes. Here, we briefly discuss strategies for generating aminium radicals from various precursors in the context of intermolecular alkene amination, and we highlight recent advances in aminium-radical-mediated hydroaminations of nonactivated olefins to directly approach alkylamines.

1 Introduction

2 Intermolecular Hydroamination of Nonactivated Alkenes with Alkylamines under Photoredox Catalysis

3 Intermolecular Hydroamination of Nonactivated Alkenes with Aliphatic Azides

4 Conclusions
Reference Density Database for 20 Aqueous Alkali Halide Solutions
Authors: Yang Fufang , Qu Jingang , Kontogeorgis Georgios M. , de Hemptinne Jean-Charles
Published: November 2022

A reference density database of aqueous alkali halide solutions is presented. The solutes are the 20 alkali halides consisting of the cations Li+, Na+, K+, Rb+, Cs+, and anions F−, Cl−, Br−, I−. Experimental density data of these aqueous electrolyte solutions are extensively collected and critically evaluated. A data evaluation procedure is proposed, utilizing support vector regression (SVR) to compare the experimental datasets against each other. Data evaluation is based on agreement with data from other sources rather than accuracy claimed in the literature. Datasets with large deviation from others are identified and removed. The proposed reference database consists of 11 081 data points of 586 datasets from 309 references. Maximum deviations between the selected datasets do not exceed 1%, and are smaller than 0.5% for most of the aqueous alkali halide solutions. SVR models are also trained based on the reference database. Data distribution is visualized using a Gaussian mixture model. Applicability domains of the SVR models are analyzed using Williams plots. An executable program is provided for calculations based on the SVR models.
Three-dimensional ESRGAN for super-resolution reconstruction of turbulent flows with tricubic interpolation-based transfer learning
Authors: Yu Linqi , Yousif Mustafa Z. , Zhang Meng , Hoyas Sergio , Vinuesa Ricardo , Lim Hee-Chang
Published: November 2022

Turbulence is a complicated phenomenon because of its chaotic behavior with multiple spatiotemporal scales. Turbulence also has irregularity and diffusivity, making predicting and reconstructing turbulence more challenging. This study proposes a deep-learning approach to reconstruct three-dimensional (3D) high-resolution turbulent flows from spatially limited data using a 3D enhanced super-resolution generative adversarial networks (3D-ESRGAN). In addition, a novel transfer-learning method based on tricubic interpolation is employed. Turbulent channel flow data at friction Reynolds numbers Reτ = 180 and Reτ = 500 were generated by direct numerical simulation (DNS) and used to estimate the performance of the deep-learning model as well as that of tricubic interpolation-based transfer learning. The results, including instantaneous velocity fields and turbulence statistics, show that the reconstructed high-resolution data agree well with the reference DNS data. The findings also indicate that the proposed 3D-ESRGAN can reconstruct 3D high-resolution turbulent flows even with limited training data.
Medicare reimbursed telehealth exercise physiology services were underutilised through the coronavirus (COVID-19) pandemic: an ecological study
Authors: Brown Riley C. C. , Coombes Jeff S. , Snoswell Centaine L. , Kelly Jaimon T. , Keating Shelley E.
Published: November 2022

Objectives To describe the quantity and cost of in-person and telehealth exercise physiology (EP) reimbursed under the Medicare Benefits Schedule (MBS) in Australia before and during the coronavirus disease 2019 (COVID-19) pandemic. Methods This study uses publicly available MBS data to describe EP services (in-person and telehealth) reimbursed by Medicare between January 2020 and December 2021. Data were extracted at state and national levels. Results Despite a reduction in quantity and cost in quartile (Q) 2 2020 (41% reduction), MBS-reimbursed EP services have remained relatively constant at a national level through the 2-year observation period. Service claims averaged 88 555 per quarter in 2020 and 95 015 in 2021. The proportion of telehealth consultations relative to total quarterly claims for EP was <1% in Q1 2020, 6.0% in Q2 2020, 2.4% in Q3 2020 and 1.7% in Q4 2020. This dropped to an average of 1.4% across 2021 (Q1–Q4). States undergoing lockdown periods reported decreased service rates relative to February 2020 (i.e. pre-lockdown). EP services were associated with a Medicare expenditure of AUD17.9M in 2020 (telehealth = 2.4% of total) and AUD19.7M (telehealth = 1.5% of total) in 2021. Conclusions Quantity and cost of MBS-reimbursed EP services remained relatively constant throughout the height of service disruption due to COVID-19 (2020/21). Telehealth uptake during this time has been minimal for EP.
Oligodendrocyte precursor cells ingest axons in the mouse neocortex
Authors: Buchanan JoAnn , Elabbady Leila , Collman Forrest , Jorstad Nikolas L. , Bakken Trygve E. , Ott Carolyn , Glatzer Jenna , Bleckert Adam A. , Bodor Agnes L. , Brittain Derrick , Bumbarger Daniel J. , Mahalingam Gayathri , Seshamani Sharmishtaa , Schneider-Mizell Casey , Takeno Marc M. , Torres Russel , Yin Wenjing , Hodge Rebecca D. , Castro Manuel , Dorkenwald Sven , Ih Dodam , Jordan Chris S. , Kemnitz Nico , Lee Kisuk , Lu Ran , Macrina Thomas , Mu Shang , Popovych Sergiy , Silversmith William M. , Tartavull Ignacio , Turner Nicholas L. , Wilson Alyssa M. , Wong William , Wu Jingpeng , Zlateski Aleksandar , Zung Jonathan , Lippincott-Schwartz Jennifer , Lein Ed S. , Seung H. Sebastian , Bergles Dwight E. , Reid R. Clay , da Costa Nuno Maçarico
Published: November 2022

Neurons in the developing brain undergo extensive structural refinement as nascent circuits adopt their mature form. This physical transformation of neurons is facilitated by the engulfment and degradation of axonal branches and synapses by surrounding glial cells, including microglia and astrocytes. However, the small size of phagocytic organelles and the complex, highly ramified morphology of glia have made it difficult to define the contribution of these and other glial cell types to this crucial process. Here, we used large-scale, serial section transmission electron microscopy (TEM) with computational volume segmentation to reconstruct the complete 3D morphologies of distinct glial types in the mouse visual cortex, providing unprecedented resolution of their morphology and composition. Unexpectedly, we discovered that the fine processes of oligodendrocyte precursor cells (OPCs), a population of abundant, highly dynamic glial progenitors, frequently surrounded small branches of axons. Numerous phagosomes and phagolysosomes (PLs) containing fragments of axons and vesicular structures were present inside their processes, suggesting that OPCs engage in axon pruning. Single-nucleus RNA sequencing from the developing mouse cortex revealed that OPCs express key phagocytic genes at this stage, as well as neuronal transcripts, consistent with active axon engulfment. Although microglia are thought to be responsible for the majority of synaptic pruning and structural refinement, PLs were ten times more abundant in OPCs than in microglia at this stage, and these structures were markedly less abundant in newly generated oligodendrocytes, suggesting that OPCs contribute substantially to the refinement of neuronal circuits during cortical development.
Identification of transient intermediates during spliceosome activation by single molecule fluorescence microscopy
Authors: Fu Xingyang , Kaur Harpreet , Rodgers Margaret L. , Montemayor Eric J. , Butcher Samuel E. , Hoskins Aaron A.
Published: November 2022

Spliceosome activation is the process of creating the catalytic site for RNA splicing and occurs de novo on each intron following spliceosome assembly. Dozens of factors bind to or are released from the activating spliceosome including the Lsm2-8 heteroheptameric ring that binds the U6 small nuclear RNA 3′-end. Lsm2-8 must be released to permit active site stabilization by the Prp19-containing complex (NineTeen Complex, NTC); however, little is known about the temporal order of events and dynamic interactions that lead up to and follow Lsm2-8 release. We have used colocalization single molecule spectroscopy (CoSMoS) to visualize Lsm2-8 dynamics during activation of
Saccharomyces cerevisiae
spliceosomes in vitro. Lsm2-8 is recruited as a component of the tri-snRNP and is released after integration of the Prp19-containing complex (NTC). Despite Lsm2-8 and the NTC being mutually exclusive in existing cryo-EM structures of yeast B complex spliceosomes, we identify a transient intermediate containing both (

B

Lsm
+
NTC

Δ
U4

) and provide a kinetic framework for its formation and transformation during activation. Prior to

B

Lsm
+
NTC

Δ
U4

assembly, the NTC rapidly and reversibly samples the spliceosome suggesting a mechanism for preventing NTC sequestration by defective spliceosomes that fail to properly activate. In complementary ensemble assays, we show that a base-pairing-dependent ternary complex can form between Lsm2-8 and U2 and U6 helix II RNAs. We propose that this interaction may play a role in formation of transient spliceosome intermediates formed during activation.
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis
Authors: An Seong J. , Anneken Alexander , Xi Zhiqun , Choi Changseon , Schlessinger Joseph , Toomre Derek
Published: November 2022

The phosphoinositide-3 kinase (PI-3K)/AKT cell survival pathway is an important pathway activated by EGFR signaling. Here we show, that in addition to previously described critical components of this pathway, i.e., the docking protein Gab1, the PI-3K/AKT pathway in epithelial cells is regulated by the exocyst complex, which is a vesicle tether that is essential for exocytosis. Using live-cell imaging, we demonstrate that PI(3,4,5)P3levels fluctuate at the membrane on a minutes time scale and that these fluctuations are associated with local PI(3,4,5)P3increases at sites where recycling vesicles undergo exocytic fusion. Supporting a role for exocytosis in PI(3,4,5)P3generation, acute promotion of exocytosis by optogenetically driving exocyst-mediated vesicle tethering up-regulates PI(3,4,5)P3production and AKT activation. Conversely, acute inhibition of exocytosis using Endosidin2, a small-molecule inhibitor of the exocyst subunit Exo70 (also designated EXOC7), or inhibition of exocyst function by siRNA-mediated knockdown of the exocyst subunit Sec15 (EXOC6), impairs PI(3,4,5)P3production and AKT activation induced by EGF stimulation of epithelial cells. Moreover, prolonged inhibition of EGF signaling by EGFR tyrosine kinase inhibitors results in spontaneous reactivation of AKT without a concomitant relief of EGFR inhibition. However, this reactivation can be negated by acutely inhibiting the exocyst. These experiments demonstrate that exocyst-mediated exocytosis—by regulating PI(3,4,5)P3levels at the plasma membrane—subserves activation of the PI-3K/AKT pathway by EGFR in epithelial cells.
Pandemic fatigue impedes mitigation of COVID-19 in Hong Kong
Authors: Du Zhanwei , Wang Lin , Shan Songwei , Lam Dickson , Tsang Tim K. , Xiao Jingyi , Gao Huizhi , Yang Bingyi , Ali Sheikh Taslim , Pei Sen , Fung Isaac Chun-Hai , Lau Eric H. Y. , Liao Qiuyan , Wu Peng , Meyers Lauren Ancel , Leung Gabriel M. , Cowling Benjamin J.
Published: November 2022

Hong Kong has implemented stringent public health and social measures (PHSMs) to curb each of the four COVID-19 epidemic waves since January 2020. The third wave between July and September 2020 was brought under control within 2 m, while the fourth wave starting from the end of October 2020 has taken longer to bring under control and lasted at least 5 mo. Here, we report the pandemic fatigue as one of the potential reasons for the reduced impact of PHSMs on transmission in the fourth wave. We contacted either 500 or 1,000 local residents through weekly random-digit dialing of landlines and mobile telephones from May 2020 to February 2021. We analyze the epidemiological impact of pandemic fatigue by using the large and detailed cross-sectional telephone surveys to quantify risk perception and self-reported protective behaviors and mathematical models to incorporate population protective behaviors. Our retrospective prediction suggests that an increase of 100 daily new reported cases would lead to 6.60% (95% CI: 4.03, 9.17) more people worrying about being infected, increase 3.77% (95% CI: 2.46, 5.09) more people to avoid social gatherings, and reduce the weekly mean reproduction number by 0.32 (95% CI: 0.20, 0.44). Accordingly, the fourth wave would have been 14% (95% CI%: −53%, 81%) smaller if not for pandemic fatigue. This indicates the important role of mitigating pandemic fatigue in maintaining population protective behaviors for controlling COVID-19.
Conceptual blending in entrenched Persian noun-noun nominal compounds
Authors: Diyanati Masoumeh , Rezaei Hadaegh , Rafiei Adel
Published: November 2022

The current paper offers an analysis of a set of 27 entrenched endocentric, exocentric, and copulative
āb (water)-noun nominal compounds in Persian with both right- and left-headed compounds, based on the network
model of conceptual blending theory. Given that an emergent meaning is involved in endocentric and copulative compounds, the same
as in exocentric compounds, the paper argues that all types of compounds can be insightfully defined as conceptual blends.
However, the conceptual blending network model fails to show the distinct role of head and modifier in the overall meaning of
compounds, on the one hand, and the qualifying difference in the extent of emergent meaning among various types of compound words,
on the other hand. Our study also lends support to a correspondence between the continuum of integration networks and the
continuum of figurativity in compounds.
Conceptual metaphor sport as war in Vietnamese football news
Authors: Hanh Nguyen Thi Bich , Huong Le Vien Lan , Hien Pham
Published: November 2022

Stemming from the widespread appearance of war metaphors in Vietnamese sports news, the article conducts the
research on the emergence of metaphors related to the source domain of war in Vietnamese sports news. The International
Commentary section aims to clarify the relationship between “sport” and “war” in Vietnamese mind maps. This article analyses the
conceptual metaphor sport as war underlying the metaphorically used words and expressions in Vietnamese sports news and
explains the mapping scheme between source domain and target domain. Based on the experiential correlations and knowledge mapped
from source domain to target domain, the article shows typical thinking of the conceptual construction, which is both universal
and typical of Vietnamese people thinking, indicating the hierarchy in conceptual thinking. The primary metaphor sport as
war, through mapping scheme, the article proves the appearance of derivative metaphors in sports news such as sports
competition as a battle between the warring parties; the footballers as military participants; the main footballers in
competition are the weapons in the war; tactics in competing in a sports event as tactics in battle; the actions of
footballers are the actions of the warring parties; fouls and misconduct are destroying an opponent in battle; coach as battle
commander; winning/losing the match as winning/losing the battle. The current study’s findings are the metaphors grouped
into categories: battle activities, battle devices, battle results/consequences, battle tactics. The article’s research results
may help journalism students in writing skills and use conceptual metaphors in writing news and articles; suggest to sports
bulletin editors how to use conceptual metaphors in news and articles to increase attraction for readers and listeners; and make
matches more excited, dramatic and attractive.
Divine and human agency in figurative language from John’s Gospel and Jodo‑Shinshu Buddhism
Authors: Richardson Peter , Nagashima Miori
Published: November 2022

This paper seeks to extend the focus of previous analyses of agency and metaphor in Christianity and Buddhism
(Charteris-Black 2017; Chilton 2004;
Richardson 2012; Richardson & Nagashima
2018) by comparing the results of a previous cognitive linguistic analysis of John 14:6 (Kövecses 2011) with an analysis of figurative language and agency patterns in an extract from a Jodo
Shinshu Buddhist text (Wilson 2009). The comparative analysis highlights both locally
contingent and more stable differences in both texts. However, we also discuss some highly schematic conceptual similarities that
deserve further study. These include some similarities in their use of journey and light source domains, the
role of the divine agent in the salvation process, one aspect of the divine entity embodying and acting as instrument for another
aspect of the same divine entity, and the divine act being a paragon for human action.
Neology pathways
Authors: Ferrucci Francesca
Published: November 2022

A quantitative analysis of the Italian lexicon has been made, focusing on the semantic relationships of
meronymy/holonymy and hyponymy/hypernymy. The study used two lexicographical sources, together representing one of the largest
structured Italian datasets. Within the theoretical debate on the ontolex interface, the aforementioned semantic
relationships can be particularly interesting, assuming their closeness to crucial aspects of cognition. In this framework, the
collected evidence legitimates some hypotheses on the pathways that underlie lexical and semantic neology: the direction from
holonym to meronym(s) appears more productive than the opposite, suggesting that the conceptualization of an object as a whole is
more likely to stimulate further conceptualization of parts, members or substance. The same top-down direction from species to
genus (genera), prevails in hypernyms/hyponyms. Recurring trends of use rates, first attestation dates, and correlation rates can
be exploited further to discuss the issue of cognitive economy and the ways in which it manifests itself in language.
Applying cognitive linguistics to foreign language teaching and learning
Authors: Wirag Andreas , Li Yunong , Zhang Bin
Published: November 2022

The discipline of Applied Cognitive Linguistics is a recent, still emerging framework, which is situated at the interface of Cognitive Linguistics (CL) and Applied Linguistics research (Pütz, Niemeier & Dirven 2001a,2001b). At its core, Applied CL is concerned with the use of CL models, theories, or concepts for L2 teaching and learning, where it aims to create effective teaching methods, activities, or materials. Owing to its more recent origin in the 1990s/2000s, a lively metadisciplinary discussion is still taking place within the discipline, which highlights various challenges or concerns that Applied CL research is currently facing (e.g.,Achard & Niemeier 2004;Pütz 2010;Roche 2014;Tyler & Huang 2018). Major concerns in this discussion are, for instance, (1) the underuse of empirical data in Applied CL research and (2) the yet limited application of CL theories to Communicative Language Teaching (as opposed to Present-Practice-Produce, in which it is typically embedded). This article outlines these two challenges to research in Applied CL and offers suggestions how to address these concerns in future investigations. By doing so, we intend to contribute to the ongoing metadisciplinary discussion about the Applied CL framework and to promote its further consolidation.
PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes
Authors: Pacheco Jonathan , Cassidy Anna C. , Zewe James P. , Wills Rachel C. , Hammond Gerald R.V.
Published: November 2022

The lipid phosphatidyl-D-myo-inositol-4,5-bisphosphate [PI(4,5)P2] is a master regulator of plasma membrane (PM) function. Its effector proteins regulate transport, signaling, and cytoskeletal processes that define PM structure and function. How a single type of lipid regulates so many parallel processes is unclear. We tested the hypothesis that spatially separate PI(4,5)P2 pools associate with different PM complexes. The mobility of PI(4,5)P2 was measured using biosensors by single-particle tracking. We found that PM lipids including PI(4,5)P2 diffuse rapidly (∼0.3 µm2/s) with Brownian motion, although they spend one third of their time diffusing more slowly. Surprisingly, areas of the PM occupied by PI(4,5)P2-dependent complexes did not slow PI(4,5)P2 lateral mobility. Only the spectrin and septin cytoskeletons showed reduced PI(4,5)P2 diffusion. We conclude that even structures with high densities of PI(4,5)P2 effector proteins, such as clathrin-coated pits and focal adhesions, do not corral unbound PI(4,5)P2, questioning a role for spatially segregated PI(4,5)P2 pools in organizing and regulating PM functions.
Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II–dependent fashion
Authors: Huet-Calderwood Clotilde , Rivera-Molina Felix E. , Toomre Derek K. , Calderwood David A.
Published: November 2022

Fibronectin (FN) is an essential structural and regulatory component of the extracellular matrix (ECM), and its binding to integrin receptors supports cell adhesion, migration, and signaling. Here, using live-cell microscopy of fibroblasts expressing FN tagged with a pH-sensitive fluorophore, we show that FN is secreted predominantly at the ventral surface of cells in an integrin-independent manner. Locally secreted FN then undergoes β1 integrin-dependent fibrillogenesis. We find that the site of FN secretion is regulated by cell polarization, which occurs in bursts under stabilized lamellipodia at the leading edge. Moreover, analysis of FN secretion and focal adhesion dynamics suggest that focal adhesion formation precedes FN deposition and that deposition continues during focal adhesion disassembly. Lastly, we show that the polarized FN deposition in spreading and migrating cells requires both intact microtubules and myosin II-mediated contractility. Thus, while FN secretion does not require integrin binding, the site of exocytosis is regulated by membrane and cytoskeletal dynamics with secretion occurring after new adhesion formation.
Predicted High-Temperature Superconductivity in Rare Earth Hydride ErH2 at Moderate Pressure
Authors: Liu Yiding , Fan Qiang , Yang Jianhui , Wang Lili , Zhang Weibin , Yao Gang
Published: November 2022

Hydrides offer an opportunity to study high critical temperature (high-T
c) superconductivity at experimentally achievable pressures. However, the pressure needed remains extremely high. Using density functional theory calculations, herein we demonstrate that a new rare earth hydride ErH2 could be superconducting with T
c ∼ 80 K at 14.5 GPa, the lowest reported value for compressed hydrides to date. Intriguingly, due to Kondo destruction, superconductivity was prone to exist at 15 GPa. We also reveal an energy gap at 20 GPa on the background of normal metallic states. At 20 GPa, this compressed system could act as a host of superconductor judged from a sharp jump of spontaneous magnetic susceptibility with an evanescent spin density of state at Fermi level. Finally, electron pairing glue for ErH2 at these three typical pressures was attributed to the antiferromagnetic spin fluctuation.
Correlated barrier charge hopping and non-Debye relaxation in columbite MnNb2O6
Authors: R Maruthi , Deshpande S K , Deshmukh V , Singh K , Thota S
Published: November 2022

A comprehensive study on the mechanism of ac-charge transport and dielectric relaxation in the MnNb2O6 columbite system has been reported. Thermally driven, Arrhenius-like behaviour of the ac-conductivity

(
σ
(
ω
,
T
)
)

is predominant at temperatures above 300 K in the frequency range 50 Hz–5 MHz with activation energies

(

E

a
c

)

lying between 0.45 and 0.38 eV. Besides, a quadratically decreasing trend in the activation energy is evident as given by:

E

a
c

(
f
)

= A + Bf + Cf
2 with the constants A (0.413 eV), B (0.023 eV Hz−1) and C (−0.004 eV Hz−2). The measured

σ
(
ω
,
T
)

data is analysed using the Double power law to explain the dispersive behaviour of electrical conductivity. These studies also provide evidence for the correlated-barrier hopping (CBH) conduction mechanism of charge carriers for temperatures in the range 173–473 K. Further, the temperature dependence of frequency exponent, s(T) displays two distinct regions both of which are associated with the CBH mechanism with slopes

∂

s
1

/

∂
T
=
−
1.9
×

10

−
3

 K−1 and

∂

s
2

/

∂
T
=
−
1.3
×

10

−
3

 K−1 in Region-I (173–300 K) and the slope

∂

s
1

/

∂
T
=
−
1.7
×

10

−
3

 K−1 with non-linear variation of s
2 in Region-II (300–473 K). However, the second region is more dominated by thermally activated Arrhenius-like behaviour. The dynamical response of complex electric modulus spectra

(

M
∗

(
ω
,
T
)
)

and the corresponding analysis using Kohlrausch-Williams-Watts method reveals the presence of a non-Debye type relaxation process with decay function exponent β lying between 0.794 and 0.840. This inference of the non-Debye type relaxation process is further supported by depressed semicircles in Nyquist plots and the higher magnitude of full width half maximum (FWHM) (≈1.44 decades) of the normalized master cusp

(

M

′
′

/

M

m
a
x

′
′

vs

ω

/

ω

m
a
x

)

compared to the FWHM ( = 1.14 decades) for ideal Debye behaviour. Both short-range and long-range conductivity regions are ubiquitous in

(

M
∗

(
ω
,
T
)
)

with a pronounced distribution of relaxation times (

τ
≈
935.8
−
0.36
μ

s) with temperature. This study further leads to the estimation of activation energy of charge carriers, E

M
= 0.44 eV which is in consonance with

E

a
c

(
f
,
T
)

.
Predicting and avoiding hazardous occurrences of stuck pipe for the petroleum wells at offshore Vietnam using machine learning techniques
Authors: Do Quang Khanh , Hoang Trong Quang , Nguyen Thang , Ong Vu Khanh Phat
Published: November 2022

Over many years, the petroleum industry has been facing the hazardous occurrences associated with drilling stuck pipe. It is actually one of the most challenging and costly problems at offshore drilling rigs, especially in the high-risk, high-cost environments as the ultra-deep or deep water. Nowadays, with the development of Artificial Intelligence these problems can be predicted and avoided by applying machine learning techniques. The purpose of study is to apply the two most powerful machine learning techniques including Artificial Neural Network (ANN) and Support Vector Machine (SVM) to predict and avoid stuck pipe occurrences for the petroleum wells at offshore Vietnam. Modeling ANN and SVM using Matlab programming language based on many actual drilling parameters to estimate the risk of stuck pipe. The output of the models of both ANN and SVM machine learning techniques is the probability of non-stuck or stuck pipe at different measured depth points. Predictive results from both ANN and SVM techniques are compared to real measurements with the accuracy of all models above 85%. These machine learning techniques can help predicting stuck pipe occurrences as well as avoiding them by considering the changes of some important drilling operational parameters.
Seismic screening and structural investigation of heritage buildings for adaptive reuse: a survey study at Iloilo City, Philippines
Authors: De Jesus Richard , Oreta Andres Winston , Grio Mary Earl , Mendoza Rodolfo , Garciano Lessandro , Ibabao Rhodella , Sevieri Giacomo , Galasso Carmine
Published: November 2022

Building adaptive reuse has been a popular strategy for cultural heritage conservation of structures for it serves two basic objectives of preserving heritage structures and promoting cultural heritage and tourism. Adaptive reuse is the adaptation of an old structure to allow the introduction of a modern function into the old structure. Old buildings are not demolished but recycled into modern uses. This strategy, however, needs a careful and thorough assessment of these existing heritage buildings to assure their resilience and sustainability to future hazards. Heritage buildings for adaptive reuse due to age and structural deterioration are highly vulnerable to hazards like earthquakes. Moreover, these buildings when used for commercial purposes may be subjected to additional loads due to changes in function. Considering the age of the structure, conformity to new design codes, additional loads imposed by unit modification, and the new function brought about by adaptive reuse of these structures, there is a need to assess these buildings to assure their safety and continuous use. Promoting adaptive reuse of heritage buildings and tourism is most appropriate in heritage zones like Calle Real in Iloilo City, the site for the case study. This paper presents a rapid seismic screening of buildings to prioritize a population of heritage buildings in a heritage zone for further detailed inspection. A site survey of the buildings was conducted at the heritage zone of Calle Real, Iloilo City in terms of their current use, and current condition to determine potential structural, maintenance, and functional issues related to resilience and to recommend future improvements in the implementation of adaptive reuse of heritage structures in cities and towns to assure their sustainability.
Fear of the fall of space objects in people of rural communities of the district of Azangaro, Peru
Authors: Calatayud-Mendoza A P , Chui-Betancur H N , Belizario-Quispe G , Huaquisto-Ramos E , Alfaro-Alejo R
Published: November 2022

The present study reports the fear scales, in adults over 18 years of age, caused by the fall of propellant tanks from outer space, considered as space debris, that occurred on January 27, 2018, in the communities of Larancahuani, Ninanuyo, Tiramaza, and Bellavista in the Azangaro district, Peru. 49 surveys with 6 items were applied to the residents surrounding the affected areas, using the fear inventory, in addition, the principal component analysis technique was applied to describe a set of information in terms of other variables that are not correlated in terms of least squares. The results show a reliability index of the items of 0.78, which implies the existence of internal consistency of the items. The first factor on affective symptoms: fear of staying overnight during the following nights is associated with a coefficient of 0.855; while the item Fear of the appearance of new diseases in people is positively related with a coefficient of 0.777; finally, the item fear of headaches and dizziness and fear of anxiety, depression, and panic are positively associated with 0.865 and 0.887 with factor 2, which are physical symptoms, which can even alter the development of daily activities of the inhabitants.
Attitude and flood preparedness of households in Pasir Mas, Kelantan, Malaysia
Authors: Diyana F A Noor
Published: November 2022

Kelantan is a state that is often impacted by the yearly monsoonal floods resulting in the displacement of a large number of households as well as damages to crops, livestock and properties. The flood is a yearly occurrence that necessitates the community to prevent loss of lives and extensive property damage; however, previous studies have found that communities are unprepared to face flood disasters, especially in flood-prone areas. Thus this study aims to determine the relationship between attitude towards flood preparedness and the level of flood preparedness of households in Pasir Mas, Kelantan. A total of 220 respondents from 10 villages were selected with the assistance of the District Office to ensure the selection of villages with experience of flood or is flood-prone. Descriptive analysis was conducted to determine the level of attitude and flood preparedness. Results from the analysis found that the attitude and preparedness level was moderate. Therefore, it is suggested that the community’s attitude and preparedness level can be further enhanced with the assistance of the responding agencies and local authorities to empower a more resilient community.
Mitigation plan against liquefaction potential on Gumbasa Irrigation Canal around Jono Oge area after 2018 Central Sulawesi Earthquake
Authors: Pratama A , Fathani T F , Satyarno I
Published: November 2022

Gumbasa Irrigation Area was one of the public infrastructures affected by the liquefaction and flow-slide. Restoring it to operate as before required a reconstruction plan with consideration on potential damage caused by the earthquake and liquefaction. The objective of this study was to assess the performance of the mitigation plan applied on Gumbasa Irrigation Area (canal and rice field). Two mitigation plans to be applied in the Gumbasa Irrigation Canal are evaluated, i.e., (1) implementing impermeable lining and geogrid; (2) applying impermeable lining and steel-sheet pile with drain. Each mitigation plan was compared using the finite element method to examine the stability and displacement mechanism. Based on the result, the first mitigation plan was identified as more effective to reduce displacement caused by earthquake and liquefaction potential. The lowering groundwater method was applied on Jono Oge rice fields area by maintaining the recommended groundwater level obtained from the simulation of groundwater level using the simplified method. We concluded that mitigation plans on irrigation canal by applying impermeable lining and geogrid and by lowering groundwater on the rice fields area were the best mitigation plan for Gumbasa Irrigation Area.
Assessment of Reservoir and Canals Revitalization to Improve The Reclamation Process at Unit Tamban Tidal Irrigation Area, Central Kalimantan
Authors: Rahajeng S S , Jayadi R , Maas A
Published: November 2022

The Unit Tamban is one of the tidal irrigation areas in the Central Kalimantan Mega Rice Project (MRP). The Unit Tamban is an irrigation system consisting of three primary canals with a settling pond or reservoir at each end. After being developed in 1970 by the Tidal Rice Field Development Project (P4S), the three reservoirs no longer function because they are full of sediment. Sedimentation also occurs in primary and secondary canals, impacting tidal attenuation and decreasing canal capacity. The reservoir at the end of the primary canal assists water regulation for irrigation purposes and leaching acid sulfate water. Three scenarios can be used to increase the capacity of the irrigation system, namely reservoir revitalization, secondary canals normalization, and combining two previous scenarios. The performance of both options was assessed by hydraulic simulation modeling using the HEC-RAS software. The hydraulic simulations show that reservoir revitalization can increase the volume of incoming water during high tide by about 90% more than without a reservoir. If the secondary canal normalization is carried out, the fresh water volume entering the secondary canal exceeds 19% before normalization.
The Effect of Various Peak Ground Acceleration Level in Petobo Irrigation Canal Area Post 2018’s Liquefaction Disaster
Authors: Sauri S , Rifa’i A , Hardiyatmo H C
Published: November 2022

The soil liquefaction disaster in Petobo, Central Sulawesi, caused massive terrain damage. With a total displacement of up to 800 meters and a total sliding area of 1.43 km2, the soil structure was deformed. The 7.5 Mw earthquake with the maximum PGA of 0.45 was causing flow-induced liquefaction with a distance from the crown to the foot of the landslide as far as 2 km. The research aims to find out how well the post-earthquake soil can withstand the potential to liquefaction if it is hit by various earthquake levels. This research will conduct several simulations to determine the soil performance against earthquakes. The empirical calculation method is carried out by referring to Idris-Boulanger to determine the liquefaction safety factor. Based on several scenarios that have been carried out, post-earthquake land can be re-liquefy when shaken by an earthquake with a certain level below the magnitude of the 7.5 Mw 2018’s Palu earthquake. There are a total of six different scenarios of earthquakes with various level of PGA. The soils still have the possibility to liquefy with the PGA of 0.20 and can be considered safe as the PGA value of 0.13. Mitigation efforts, including soil remediation, must be carried out before reconstructing phase of the Petobo irrigation canal starts.
Potential Application and Future Prospects of Algal-Bacterial Aerobic Granular Sludge for Wastewater Treatment
Authors: Purba L D A , Shimizu K , Hermana J
Published: November 2022

Algal and bacterial consortia have a high potential to enhance wastewater treatment efficiencies. Algae have been embedded into aerobic granulation process allowing interactions between algal and bacterial cells within the sludge whereby granular flocs were successfully formed. The unique structure of algal-bacterial aerobic granules leads to easier separation between sludge and treated wastewater. The bibliographic data shows increasing interest in the field of algal-bacterial aerobic granular sludge due to the high treatment efficiency in treating different types of wastewaters, including those containing heavy metals and antibiotics. Moreover, the algal-bacterial aerobic granules may be harvested by the end of treatment process for extraction of biolipid for possible resource recovery in form of biofuel. The applications and resource recovery of this system is thoroughly elucidated in this article.
Analysis of Rock Mass Surface Colour using CIELAB and Munsell Chart
Authors: Razali M. , Ismail M.A.M , Yusoff I. N. , Tobe H. , Miyoshi T. , Date K. , Yokota Y.
Published: November 2022

Rock mass surface colour is crucial for weathering assessment. CIELAB colour space and Munsell chart are methods to express the surface colour of rock masses. This study analysed the L*a*b* value from both approaches and examined the effectiveness and reliability of rock slope weathering assessment method. The Munsell Rock chart is a conventional method primarily used in practice. However, due to the constraint of individual vision and variation in the optical environment, errors and bias in rock surface colour can easily occur using the conventional method. The colourimeter was used to determine the CIELAB colour values of the samples, while the rock colour chart determined the colour coordinates and Munsell values. The Munsell hue and chroma were assigned using linear interpolation by Munsell conversion software CMC 2.1 to convert Munsell colour systems to L*a*b* value. A total of six granitic rock slopes were investigated. For quantitatively method, the Munsell optical system was less effective in assessing the rock mass surface colour. The positive correlation of a* and b* with R2=0.9407 demonstrated the efficiency of CIELAB system. The a*b* result of the rock slope indicated that most of the slopes were considered medium to strong with a moderately weathered surface. This result is strongly supported by a geomechanical test of Schmidt-UCS and index properties (Id2) with a range of 50-100 MPa and 2-4 MPa respectively. The finding verified mineralogical assessment which showed the correlation of rock mass surface colour to mineral composition. The study recommended any geotechnical and technical purpose in enhancing the method of weathering assessment by using the CIELAB colour space to rapidly and efficiently measure the rock surface colour.