bluuebunny/crossref_metadata_2025 huggingface dataset:
KARAKTERISASI SIMPLISIA DAN SKRINING FITOKIMIA DAUN JERUK LEMON (Citrus limon (L.) Burm.f.)
Authors: Mayasari Ulfayani , Laoli Melfin Teokarsa
Published: November 2022

Lemon Citrus (Citrus limon (L.) Burm f.) is one of the plants that has potential as a traditional medicine, and is an excellent source of vitamin C and calcium. Lemon leaf lemon can help overcome cancer, heart and liver. The purpose of this research is to characterize simplicia leaf and to know the chemical compound group contained in leaf. Characterization of simplicia include macroscopic and microscopic examination, determinations of loss on drying, determinations of water soluble extract, determination of ethanol soluble concentration, determination of total ash content, and determination of acid ash in soluble. Phytochemical screening includes the test for alkaloids, flavonoids, steroids/triterpenoids, tannins and saponins. The result obtained from examination of lemon citrus leaf characteristic gave loss on drying 69,29%; total ash content 6,40%; acid insoluble ash 1,23%; ethanol soluble extract 17,73%; water soluble extract 24,79%. The result of phytochemical screening showed that lemon leaf simplicia extract contains alkaloids, flavonoids, steroids/triterpenoids and tannins.
AKTIVITAS EKSTRAK DAUN PIRDOT (Saurauia vulcani) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli
Authors: Gaol Eva Lumban , Mayasari Ulfayani
Published: November 2022

Pirdot is a natural medicinal plant contains flavonoids that has antibacterial properties. The bacteria tested in this experiment is E. coli that causes of diarrhea. This study was to determine the antibacterial effect of pirdot leaves made in an extract preparation by the diffusion method using paper discs.. This study also used Tetracycline as a comparison, where this antibiotic is very sensitive to E. coli bacteria. Pirdot leaf extract was made in various concentrations, namely 12.5%, 15%, 17.5% and 20% and 20 mcg and 30 mcg of Tetracycline concentrations. The results showed that pirdot leaf extract in E. coli was able to inhibit with a concentration of 12.5% of 10.41 mm, 15% of 11.71 mm, 17.5% of 14.08%, and 20% of 15.43 mm, while the 20 mcg Tetracycline comparison was 18.73 mm and 20.71 mm at 30 mcg. So the conclussion from this research are the concentration of 12.5% and 15% can not be not said to be antibacterial but at concentrations of 17.5% and 20% can be said to be antibacterial.

Keywords: Pirdot leaf, Eschericia coli, antibacterial.  
PENGARUH PEMBERIAN PUPUK ORGANIK CAIR LIMBAH BUAH PEPAYA TERHADAP PERTUMBUHAN DAN HASIL TANAMAN TOMAT (Solanum lycopersicum L)
Authors: Hamid Sonia Hamid , Febriani Husnarika , Tambunan Efrida Pima sari
Published: November 2022

This study aims to determine levels of nutrients N, P, K, C- organic and ratio of C/N on papaya fruit liquid organic fertilizer, knowing the effect of giving papaya fruit liquid organic fertilizer on growth and yield tomato plants (Solanum lycopersicum L) and find out the optimal concentration of liquid organic fertilizer of papaya waste on the growth anad yield of tomato plants (Solanum lycopersicum L). This research was conducted at the green house, Faculty of Science and Technology, North Sumatra State Islamic University in November to February 2020. The paraneters used are stem height, Number of leaves, Number of branches, number of flowers, and number of fruits. This study used a completely randomized design with four treatment and five replication as the trearment used is treatment 0 (0 %) , treatment 1 (10 %), treatment 2 (20 %), treatment 3 (30 %). The highest research results were found in treatment 3 concentrations of 300 %, while treatmen 2 concentrations of 200 % and treatment 1 concentrations of 100 % good growth, while the lowest growth was found in control.

 

Keywords: Tomatoes, Liquid Organik Fertilizer, Papaya Waste.

 
STATUS BERAT BADAN MENCIT (Mus musculus) BALB/C SETELAH INFEKSI Plasmodium berghei
Authors: Syukriah Syukriah
Published: November 2022

Malaria is an infectious disease caused by Plasmodium, which is a single-celled creature that belongs to the group of protozoa. This disease attacks all age groups, both men and women. Malaria can cause death especially in high risk groups namely infants, children under five, pregnant women, besides malaria directly causes anemia and can reduce work productivity. The study design uses a complete randomized design  with 4 treatment groups. Group 1 is the control group without any treatment. Group 2 was injected with 1 × 102 iRBC. Group 3 is injected with 1 × 103 iRBC. Group 4 was injected with 1 × 104. The treatment was given for 30 days. Measurement of body weight was done every day. Examination of the degree of parasitemia was carried out on day 3 after infection with the thin blood smear method. Data measured body weight and degree of parasitemia were analyzed by one way ANOVA and DMRT tests at a significant level of 5%. The results showed a significant difference in body weight between mice infected with parasites versus those not infected. The more doses of parasites that were infected the more it will affect the mice. The conclusion of this research is P. berghei infection gives weight loss effect on balb/c mice.

 
Keywords: malaria, Plasmodium berghei, weight
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SEREH WANGI TERHADAP PERTUMBUHAN BAKTERI STREPTOCOCCUS MUTANS
Authors: Mayasari Ulfayani , Sapitri Alfi
Published: November 2022

The lemongrass plants (Cymbopogon nardus) is one of the plants used as medicine such as strep throat, cough and colds. The purpose of this study was to determine whether the juice of fragrant lemongrass leaves has antibacterial activity against Streptococcus mutans bacteria that cause dental caries. The research method used is experimental with agar diffusion. The experiment consisted of four treatments namely at concentrations of 20%, 30%, 40% and 50% with three repetitions. The results showed fragrant lemongrass leaves at concentrations of 10%, 20%, 30% and 40% had an average inhibition zone diameter of 14,2 mm, 15,1 mm, 16,2 mm dan 17,3 mm. Fragrant lemongrass leaves can inhibit the growth of Streptococcus mutans.

Keywords : Cymbopogon nardus, Antibacterial, Streptococcus mutans.

 
Non-periodic groups with the restrictions on the norm of cyclic subgroups of non-prime order
Authors: Drushlyak M. , Lukashova T.
Published: November 2022

One of the main directions in group theory is the study of the impact of characteristic subgroups on the structure of the whole group. Such characteristic subgroups include different $\Sigma$-norms of a group. A $\Sigma$-norm is the intersection of the normalizers of all subgroups of a system $\Sigma$. The authors study non-periodic groups with the restrictions on such a $\Sigma$-norm -- the norm $N_{G}(C_{\bar{p}})$ of cyclic subgroups of non-prime order, which is the intersection of the normalizers of all cyclic subgroups of composite or infinite order of $G$. It was proved that if $G$ is a mixed non-periodic group, then its norm $N_{G}(C_{\bar{p}})$ of cyclic subgroups of non-prime order is either Abelian (torsion or non-periodic) or non-periodic non-Abelian. Moreover, a non-periodic group $G$ has the non-Abelian norm $N_{G}(C_{\bar{p}})$of cyclic subgroups of non-prime order if and only if $G$ is non-Abelian and every cyclic subgroup of non-prime order of a group $G$ is normal in it, and $G=N_{G}(C_{\bar{p}})$.Additionally the relations between the norm $N_{G}(C_{\bar{p}})$ of cyclic subgroups of non-prime order and the norm $N_{G}(C_{\infty})$ of infinite cyclic subgroups, which is the intersection of the normalizers of all infinite cyclic subgroups, in non-periodic groups are studied. It was found that in a non-periodic group $G$ with the non-Abelian norm $N_{G}(C_{\infty})$ of infinite cyclic subgroups norms $N_{G}(C _{\infty})$ and $N_{G}(C _{\bar{p}})$ coincide if and only if $N_{G}(C _{\infty})$ contains all elements of composite order of a group $G$ and does not contain non-normal cyclic subgroups of order 4.In this case $N_{G}(C_{\bar {p}})=N_{G}(C_{\infty})=G$.
The Influence Of Financial Performance, Macroeconomic Indicators And Systemic Risk On Manufacturing Sector Sharia Share Return
Authors: Siswanto Rizky , Pramono Sigid  Eko , Ismal Rifki
Published: November 2022

The purpose of this study is to examine and analyze the effect of financial performance as measured using Return On Assets (ROA), Current Ratio (CR) and Earning Per Share (EPS), macroeconomic indicators using the BI rate, exchange rate and inflation as well as adding systematic risk as the intervening variable on sharia stock returns in the manufacturing sector on the Indonesian Sharia Stock Index (ISSI). The research sample was 51 companies with a range of observations from 2016 to 2020, using the Structural Equation Modeling (SEM) method and IBM AMOS (Analysis of Structural Moment) V.22 software for testing the available data. The findings of the direct test results show that financial performance and systematic risk have an effect on Islamic stock returns, while macroeconomic indicators have no effect. The test results through the intervening variable found that financial performance had an effect, but macroeconomic indicators still had no effect on Islamic stock returns through systematic risk. Activities in the consumer goods industry and basic industry which have always been the main needs are the reason why issuers in the manufacturing sector at ISSI are not affected by changes in macroeconomic indicators.
Identifikasi Faktor Penentu Kesiapan Daerah di Indonesia untuk Berpartisipasi dalam Masyarakat Ekonomi ASEAN: Studi Kasus Kalimantan Timur
Authors: Prakoso Lukman Yudho
Published: November 2022

Hingga saat ini Indonesia semakin terkoneksi dengan negara-negara lain di Asia Tenggara dengan dimulainya Masyarakat Ekonomi ASEAN. Salah satu perkara yang menjadi perhatian para pakar dan pemangku kepentingan adalah kurang kompetitifnya Indonesia dibandingkan negara-negara tetangga dalam praktik ekonomi yang terintegrasi tersebut. Terlebih, di dalam negeri Indonesia sendiri pembangunan ekonomi dan pembangunan manusia antardaerah, khususnya antara pusat dan daerah, terlihat jelas ketimpangannya. Artikel ini berusaha mengidentifikasi faktor-faktor penentu kesiapan daerah di Indonesia untuk berpartisipasi dalam Masyarakat Ekonomi ASEAN. Sebagai studi kasus, dipilih Provinsi Kalimantan Timur. Pengumpulan data dilakukan baik secara kualitatif melalui wawancara mendalam, maupun secara kuantitatif melalui kuesioner. Informan kunci dalam penelitian ini terdiri atas instansi-instansi yang menjadi pemangku kepentingan di Provinsi Kalimantan Timur. Analisis data dilakukan melalui analisis SWOT.
Rancang Bangun Sistem Informasi Kas Karyawan dan Pemasaran PT Aryan Indonesia (Kidzania Jakarta)
Authors: Sarah Sarah , Sunoto Imam , Aziz Ahmad Haris Muchsin
Published: November 2022

Dirancangnya suatu sistem kas karyawan dan pemasaran pada PT Aryan Indonesia (Kidzania Indonesia) dengan tujuan untuk memproses pengolahan data kas karyawann dan pemasaran yang ada saat ini. Perangkat aplikasi yang telah dibuat dengan bahasa pemrograman Java NetBeans 8.0.2 dan penyimpanan data pada database MySQL dapat memberikan kelancaran dalam menginput dan penyimpanan data-data serta laporan-laporan yang diberikan kepada Pimpinan perusahaan. Dengan menggunakan metode pengembangan sistem yaitu Waterfall dalam penelitian ini adalah dengan tahapan-tahapan seperti rekayasa sistem, analisis, desain, coding, testing, dan maintenance. Diharapkan sistem informasi kas karyawan dan pemasaran ini dapat menciptakan aplikasi untuk pendataan data karyawan serta kas karyawan yang efektif dan efisien.
Perancangan Sistem Aplikasi Penjualan Makanan di Kantin Paramadina Berbasis Java Netbeans
Authors: Rifai Ardi , Parulian Dudi , Rahayu Wanti
Published: November 2022

Perancangan Sistem penjualan makanan dikantin paramadina merupakan sebuah sistem untuk mengelola data pemesanan, data pembayaran dan konfirmasi pembayaran yang bertujuan untuk memudahkan dalam memberikan pelayanan yang optimal terhadap pelanggan. Penelitian ini dilakukan melalui tahapan, yaitu observasi, perumusan dan identifikasi masalah, pengumpulan data, analisis sistem, desain sistem dan implementasi, dan pengujian sistem. sistem informasi penjualan makanan dikantin paramadina berbasis java netbeans yang dirancang dan dibangun dalam penelitian ini memiliki konsep desktop yang mampu melakukan penjualan, pembelian, pemasaran barang / produk, dan proses transaksi. Dengan menggunaan metode pengembangan sistem yaitu Waterfall dalam penelitian ini adalah dengan tahapan-tahapan seperti analisa kebutuhan sistem, studi kepustakaan, pengumpulan data dan perancangan, pengkodean sistem, serta pengujian sistem. Pada penelitian ini telah dirancang sebuah sistem penjualan yang dibuat menggunakan alat bantu perancangan sistem yaitu dengan menggunakan bahasa pemrograman Java dengan Netbeans IDE, dan database MySql menggunakan Xampp serta dengan melakukan pengujian dengan menggunakan metode black box. Hasil dari penelitian ini adalah untuk mewujudkan sistem yang efisien dan efektif bagi kantin paramadina
Sistem Administrasi Guru TPQ An-Nabaa Jakarta Timur Berbasis Java
Authors: Amalia Nabilah Farhana Nurul , Fitriansyah Aswin , Febriyanti Chatarina
Published: November 2022

Tujuan dari penelitian ini untuk memberikan kemudahan dalam pengelolaan data administrasi guru. Pengolahan data menjadi lebih efektif dan efisien, serta keamanan dan akurasi data lebih terjamin. Metodologi penelitian yang digunakan yaitu teknik pengumpulan data seperti wawancara, observasi, serta melakukan penelitian kepustakaan yang relevan. Dimana dalam membangun sistem ini digunakan alat bantu perancangan sistem yaitu Diagram Alir Data (DAD) Konteks, Nol dan Rinci serta dengan menggunakan bahasa pemrograman Java dengan Netbeans dan database MySQL menggunakan XAMPP. Hasil dari penelitian ini adalah adanya sistem administrasi yang dapat mempermudah dalam mengolah data guru, data absensi, data jadwal mengajar dan cuti, dan data gaji guru yang tersimpan di dalam database.
Rancangan Aplikasi Simpan Pinjam Untuk USPK Keluarga Besar RT 012 RW 02 Kelurahan Kalisari
Authors: Khoirunnisa Nurul , Shela Marsiani Ega , Arie Prabowo Hanggono
Published: November 2022

USPK atau Usaha Simpan Pinjam Keluarga adalah salah satu bidang usaha yang dibangun oleh Ketua RT 012 yang mempunyai kegiatan utama adalah menyediakan jasa simpan pinjam kepada warga dengan tujuan untuk membantu anggota dan warga lain yang membutuhkan biaya mendesak. Pada faktanya USPK masih mengalami banyak masalah yaitu sistem yang berjalan dilakukan dengan cara manual, hal ini mengakibatkan proses yang dilakukan menjadi kurang maksimal. Sesuai dengan masalah yang terjadi, maka terbentuklah rumusan masalah yang peneliti jelaskan adalah merancang aplikasi simpan pinjam secara komputerisasi, membuat database untuk menyimpan semua data agar tidak tercecer maupun rusak serta memberi kemudahan kepada admin untuk melakukan pekerjaannya. Adapun tujuannya untuk merancang, mengembangkan dan membuat aplikasi simpan pinjam yang sedang berjalan ke dalam sebuah aplikasi dengan menggunakan database MySQL.  Metodologi  yang digunakan dalam perancangan aplikasi simpan pinjam ini adalah metode kuantitatif. Selain itu, peneliti juga melakukan penelitian dengan metode pengumpulan data yang meliputi studi lapangan dan studi kepustakaan. Dalam proses pengembangan sistem peneliti menggunakan metode waterfall. Kesimpulan dari hasil penelitian adalah mempermudah pihak perusahaan dalam proses penginputan data dengan cara mengimplementasikan rancangan aplikasi yang terkomputerisasi, sehingga dapat mengurangi faktor kesalahan manusia dan permasalahan dalam proses pengelolaan data simpan pinjam dapat teratasi.
Validitas Instrumen Pengembangan Video Pembelajaran Matematika Berbasis Software Sparkol Videoscribe Pada Materi Peluang Kelas VIII SMP/Sederajat
Authors: Rahmadani Yelvi Rahmadani , Astuti Astuti , Ediputra Kasman
Published: November 2022

Penelitian ini dilatar belakangi berdasarkan masalah yang ada di sekolah yaitu kurangnya minat belajar siswa pada pembelajaran matematika, dan ini perlu adanya inovasi pembaharuan media pembelajaran yang digunakan di sekolah pada saat proses belajar mengajar. Penelitian ini bertujuan untuk menghasilkan validasi instrumen berkualitas yang akan digunakan dalam melakukan penilaian terhadap video pembelajaran matematika berbasis software sparkol videoscribe. Penelitian pengembangan ini menggunakan model Plomp. Model Plomp terdiri atas 3 tahap, preliminary research, prototyping phase and assesment phase. Subjek penelitian ini yaitu 3 orang validator ahli yang berkompetensi dibidangnya masing-masing. Penelitian ini menggunakan instrumen validitas, praktikalitas dan efektifitas. Data penelitian ini dikumpulkan menggunakan lembar observasi, wawancara dan angket. Teknik analisis data yang digunakan yaitu analisis data pendahuluan, analisis data validitas, analisis data praktikalitas dan analisis data efektivitas. Berdasarkan hasil dari penilaian lembar wawancara, observasi dan angket menggunakan validasi instrumen menyatakan bahwa ketiga lembar penilaian tersebut berada pada kategori sangat valid, sehingga lembar wawancara, observasi dan angket telah dapat digunakan untuk memperoleh data penilaian maupun informasi terhadap kebutuhan penelitian.
Validasi Instrumen Eksplorasi Etnomatematika Seni Silat Persembahan Kampar (PERSIMO) dan Seni Tari Pasombahan Khas Kampar
Authors: Ahadna Yusi , Astuti Astuti , Rizki Lussy Midani
Published: November 2022

Penelitin ini bertujuan untuk mengetahui kevalidan instrumen yang akan digunakan dalam penelitian eksplorasi etnomatematika seni silat persembahan Kampar (PERSIMO) dan seni Tari Pasombahan khas Kampar. Subjek pada penelitian ini berjumlah 3 orang validator yang ahli dibidangnya. Berdasarkan hasil dari validasi lembar wawancara, validator menyatakan bahwa lembar intrumen wawancara berada pada kategori valid, sehingga lembar wawancara dapat digunakan untuk mendapatkan data dilapangan sesuai dengan kebutuhan penelitian.
Artificial Neural Network Model for Wastewater Projects Maintenance Management Plan
Authors: Al-Saady Atheer , Rezouki Sedqi E.
Published: November 2022

Wastewater projects are one of the most important infrastructure projects, which require developing strategic plans to manage these projects. Most of the wastewater projects in Iraq don’t have a maintenance plan. This research aims to prepare the maintenance management plan (MMP) for wastewater projects. The objective of the research is to predict the cost and time of maintenance projects by building a model using ANN. The research sample included (15) completed projects in Wasit Governorate, where the researcher was able to obtain the data of these projects through the historical information of the Wasit Sewage Directorate. In this research artificial neural networks (ANN) technique was used to build two models (cost and time) for the maintenance of wastewater projects. The output shows there is a high correlation (R) between real and expected cost with 95.4%, minimized testing error (8.5%), and training error (19%). The mean absolute present error (MAPE) and Average Accuracy Percentage (AA) are (13.9% and 86.1%) respectively. Also, the results showed a strong correlation (R) between actual and predicted time (99.1%), minimized testing error (8%), and an additional MAPE% and AA% with (11.7% and 88.3%) respectively. These models are in agreement with the real values, as well as gives good prediction for future maintenance projects.
Comparative Study on the Hardness of Mechroha Water Springs
Authors: Rouaiguia Issam , Bouamrane Ali , Benselhoub Aissa
Published: November 2022

The vacancy of natural resources is undoubtedly limited by time. The sustainable development principle recommends modern technology for its protection and renewal. This project conducted analyses on two underground water sources in the north of Algeria (Mechroha Province). Besides, the use of the hardness factor and the adoption of the titration method, which is  the determining the concentration of an unknown solution using a known solution concentration, have permitted the characterization of the examples taken and to verify their conformity to the standard required, the results found showed HT=6.66 French degrees (oF) ) for Ain Guilloume water spring in comparison to Ain Messai water spring HT=7 French degrees (oF). Those data conduct us to select the drinking water source of Ain Guilloume due to its attractive composition and value.
Impact of Glass Waste on the Flexural, Compressive, and Direct Tension Bonding Strengths of Masonry Bricks
Authors: Al Zahawi Serwan
Published: November 2022

The waste material problem in today's world has become a major topic affecting all sectors of human life. Researchers are interested in providing solutions for each kind of waste material. Waste glass is one of the waste materials whose amounts increase daily. This article deals with two types of modified cement mortar with glass granular in the masonry wall to find their effect on the wall's property (direct tensile, flexural, and compressive bond strength). Seven different mixes were prepared according to the used glass granular ratio (three mixes contained white glass with 15, 20, and 25% while three of them contained green glass granular 5, 10, and 15%, and the last mix was a controlled mix which contains no glass granular).Based on the obtained result, the used white glass granular provides optimum compression and direct tensile bond strength when 20% of sand is replaced with white glass granular; optimum direct tensile bond value was obtained, which increased by 1.4% and increased compressive strength by 13.08% compared to control mortar. Green glass granular provides optimum compression and direct tensile bond strength when 10% of sand is replaced, direct tensile strength by 1.02%, and increased compressive strength by 3.7% compared to control mortar. The increase of the used waste glass granular in the mortar decreases flexural bond strength, and the amount of decrease depends on the chemical glass compositions.
POLA AKTIVITAS DAN PEMANFAATAN RUANG TERBUKA PUBLIK ALUN -ALUN PURWOKERTO PADA MASA PANDEMI OMICRON
Authors: Pilar Abadi Vincensius Oktsaga , Hardiman Gagoek , Radityo Harsitanto Bangun Indrakusumo
Published: November 2022

Berbagai belahan dunia khususnya di Indonesia tengah terkena pandemi yang baru yakni omicron Oleh kejadian ini peneliti sangat tertarik melakukan penelitian tentang pola aktivitas dan pemanfaatannya pada alun alun Purwokerto pada saat pandemi omicron. Alun alun Purwokerto merupakan plaza komunal yang berada di pusat  kota Purwokerto kabupaten banyumas, alun alun Purwokerto ini merupakan ruang terbuka yang dipergunakan untuk interaksi sosial orang yang berada disekitar alun alun maupun orang yang melewati alun alun purwokerto, ruang publik ini mempunyai Kawasan yang terbatas, untuk dapat menjalankan behaviour setting dengan baik maka perlu dikontrol maupun dikendalikan. Tujuan dari penelitian ini yaitu mengetahui apa saja pola aktivitas dan pemanfaatan ruang publik pada alun alun Purwokerto dengan cara mengkaitkan waktu, ruang aktivitas, dan pelaku aktivitas pada saat pandemi omicron. Hasil dari penelitian ini akan bisa dipakai untuk pengembangan kawasan alun alun Purwokerto pada masa mendatang. Dipenelitian ini peneliti memakai metode kualitatif fenomenologis dengan melakukan pengamatan pada lingkungan yang berada di alun alun Purwokerto pada pagi, tengah hari, dan petang yang bertepatan dengan hari kerja dan hari libur. Dengan demikian diharapkan  mendapatkan  pola aktivitas dan pemanfaatan ruang publik dialun alun Purwokerto
Faktor-Faktor yang Mempengaruhi Kejadian Stunting terhadap Balita menggunakan Analisis Regresi Logistik
Authors: Safitri Elfira , Basriati Sri , Mulyani Septia
Published: November 2022

Stunting is a condition of failure to thrive in toddlers due to chronic malnutrition, resulting in toddlers or children being too short for their age standards. The purpose of the study was to determine the factors that influence the incidence of stunting to toddlers at the Public Health Center Kasih Ibu airtiris, kampar. The method used in this study is the binary logistic regression method. Based on the results of the study indicate that the factors that influence the incidence of stunting in toddlers at Public Health Center Kasih Ibu airtiris, kampar namely the nutritional status of body weight based on age. The binary logistic equation with the resulting logit function is . The value of the determination of the classification of stunting events using binary logistic regression is 83,6%.
Differential expression of CERKL in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published and public data (3, 4). We found significant differential expression of CERKL, encoding ceramide kinase-like, in the skeletal muscle of patients with ALS. CERKL was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. CERKL transcript was present at significantly higher levels in ALS patient skeletal muscle as compared to control skeletal muscle. These analyses will begin to define the transcriptional landscape of ALS.
Differential expression of SIM1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published microarray data (3, 4). We found significant differential expression of SIM1, encoding single-minded family bHLH transcription factor 1, in the skeletal muscle of patients with ALS. SIM1 was also differentially expressed in primary motor neurons isolated from patients with ALS. SIM1 transcript was present at significantly lower levels in skeletal muscle from patients with ALS as compared to skeletal muscle from control individuals. These analyses will begin to define the transcriptional landscape of ALS.
Differential expression of SAMSN1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of SAMSN1, encoding SAM domain, SH3 domain and nuclear localization signals 1, in primary motor neurons of patients with ALS. SAMSN1 was also differentially expressed in fibroblasts isolated from patients with ALS. SAMSN1 transcript was present at significantly higher levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Lattices, Order
Authors: Lobo Matheus Pereira
Published: November 2022

LATTICES, ORDER and their underlying definitions and theorems are presented in this white paper (knowledge base).
Differential expression of CHRNA1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of CHRNA1, encoding cholinergic receptor nicotinic alpha 1 subunit, in the skeletal muscle of patients with ALS. CHRNA1 was also differentially expressed in primary lower motor neurons isolated from patients with ALS. CHRNA1 transcript was present at significantly higher levels in ALS patient skeletal muscle as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
bahaya minuman keras bagi kesehatan masyarakat
Authors: IRWANTO JAKA
Published: November 2022

Maraknya minuman keras (Miras) yang banyak dikonsumsi oleh masyarakat di beberapa wilayah di Indonesia, kini semakin meresahkan dengan munculnya fenomena Miras oplosan yang telah merenggut banyak korban. Berkaitan tersebut, Direktur Bina Kesehatan Jiwa Kementerian Kesehatan RI, dr. Eka Viora, Sp.J (K), menjelaskan bahwa jenis alkohol pada Miras oplosan berbeda dengan minuman beralkohol yang biasa dikonsumsi manusia.
Passive Acoustic Monitoring in difficult terrains: the case of the Principe Scops-Owl
Authors: Freitas Bárbara , Bas Yves , Robert Aloïs , Doutrelant Claire , Melo Martim
Published: November 2022

Many species are difficult to study either due to their rarity, elusiveness, difficult access to their area of occurrence, or any combination of these. This can be particularly problematic for threatened species. Passive acoustic monitoring (PAM) is a recently developed survey technique that has shown great potential in addressing this problem for species that communicate through vocalizations. However, the large amount of data it generates can be difficult to process manually. Here, we present an entirely automatic workflow to record and detect the vocalizations of a bird species that is both elusive (nocturnal) and restricted to difficult terrain in the most remote rainforests of an oceanic island: the recently discovered Principe Scops-Owl. Specifically, we evaluated (i) the performance of the workflow to monitor the presence of the owl, (ii) we assessed the most suitable time for monitoring it; and (iii) we examined the potential of this species to present detectable vocal individual signatures. For 12 days, we deployed omnidirectional recording stations (AudioMoth devices) in 72 points along 10 transects that were surveyed during one night at the same time by observers in the field. We trained TADARIDA, a machine learning software toolbox, to automatically detect owl calls. Results on the presence of the owl per site were similar for both methods. The automatic workflow showed that the owl is active during the whole night and the PAM recording setting should encompass at least the 21-23 h interval. Possibly, vocalizations had individual signatures – but the small sample size and temporal window prevented a definite conclusion. The automatic workflow developed here is an efficient method to monitor the Principe Scops-Owl and can be easily adapted for other elusive vocal species.
Legacy Chemical Pollutants in House Dust of Pregnant African Americans in Atlanta
Authors: Barr Kathryn J. , Johnson Cierra L. , Cohen Jordan , D'Souza Priya , Gallegos Estefani Ignacio , Tsai Chia-Chen , Dunlop Anne L. , Corwin Elizabeth J. , Barr Dana Boyd , Ryan P. Barry , Panuwet Parinya
Published: November 2022

We developed and applied a method for measuring selected persistent organic pollutants (POPs) [i.e, polybrominated diphenyl ethers (PBDEs), organochlorine pesticides, and polychlorinated biphenyls (PCBs)] in dust collected from pregnant African Americans (AAs) in Atlanta. Our method used a liquid-liquid extraction followed by cleanup using a Florisil solid phase extraction car-tridge. We analyzed the extracts using gas chromatography-tandem mass spectrometry with electron impact ionization and multiple reaction monitoring. Quantification was achieved using isotope dilution calibration. Limits of quantification were ranged from 0.10-2.50 ng/g dust. NIST standard reference material measurements demonstrated the robustness of our method. Our ac-curacies ranged from 82-108%, relative standard deviations ranged from 2-16%, and extraction recoveries ranged from 76-102%. We measured POPs in dust collected from 34 homes of pregnant AAs participating in the Atlanta AA birth cohort study who were enrolled from 2016-2019. Concentrations of POPs were detected in all samples with the frequencies of detection ranging from 8-100%. Concentrations of PBDE congeners 99 and 47, p,p’-DDT, and PCB153 were detected at some of the highest concentrations with geometric means of 1270, 730, 63.4 and 240 ng/g, re-spectively. The ratio of DDT/DDE was quite large (~2.7) indicating that p,p’-DDT remains intact in homes for long periods of time. These data demonstrate that care should be taken to remediate POPs in indoor dust, especially in vulnerable, disparate segments of the population.
Attributionist Group Agent Responsibility
Authors: Piovarchy Adam
Published: November 2022

A number of philosophers have recently argued that group agents can be morally responsible for their actions in virtue of having a certain kind of structured decision-making procedure which is responsive to reasons. However, accounts of group agent blameworthiness face some objections. One is that group agents cannot be responsible for wrongdoing because they are unable to experience certain kinds of emotional responses (Thompson, 2018). Another is that group agents who regularly commit wrongdoing due to certain structural impediments will always be excused for their wrongdoing. This paper demonstrates such problems can be avoided by adopting an Attributionist theory of group moral responsibility. On this approach, though group agents lack certain capacities, their ability to deny that certain facts provide moral reasons to act in certain ways is sufficient to mean they hold objectionable attitudes towards us, and those attitudes are sufficient to make group agents blameworthy.
Differential expression of B3GALNT2 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published and public data (3, 4). We found significant differential expression of B3GALNT2, encoding beta-1,3-N-acetylgalactosaminyltransferase 2, in the motor neurons of patients with ALS. B3GALNT2 was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. B3GALNT2 transcript was present at significantly lower levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
The forearc ophiolites of California (USA) formed during trench-parallel spreading: kinematic reconstruction of the western USA Cordillera since the Jurassic
Authors: Arkula Cemil , Lom Nalan , Wakabayashi John , Rea-Downing Grant , Qayyum Abdul , Dekkers Mark , Lippert Peter , van Hinsbergen Douwe
Published: November 2022

Ophiolites, fragments of oceanic lithosphere exposed on land, are typically found as isolated klippen in intensely deformed fold-thrust belts spanning hundreds to thousands of kilometers along-strike. Ophiolites whose geochemistry indicates that they formed above subduction zones, may have been relics of larger, once-coherent, oceanic lithosphere tracts that formed the leading edge of an upper plate below which subduction occurred; such tracts were subsequently dismembered by deformation and erosion during orogenesis and uplift. However, to what extent the first-order original coherence is maintained between ophiolitic klippen is difficult to assess. Here, we aim to evaluate whether the Jurassic forearc ophiolites overlying subduction complex rocks in California, now scattered over 1000 km and dismembered by the wider San Andreas Fault Zone, still maintain their original lithospheric coherence. To this end we (i) compile available crustal ages from all ophiolite klippen exposed in the Jurassic ophiolite belt of the western United States; (ii) review and kinematically reconstruct post-middle Jurassic deformation that occurred between the modern western coast and the stable North American craton to restore the original positions of the ophiolite fragments relative to each other and to North America, and (iii) perform a paleomagnetic analysis of a sheeted dyke sections of the Mt. Diablo and Josephine ophiolites to estimate the orientation of the spreading axis at which the Jurassic Californian forearc ophiolites formed. The latter analysis reveals that the original ridge orientation likely trended ~080-260°, near-perpendicular to the orientation of the trench along the western margin of the ophiolite belt. We show that with these constraints, a straightforward ridge-transform system can explain the age distributions of the ophiolites with spreading rates of 7-10 cm/a. Our analysis shows that the Jurassic ophiolites of California may be considered klippen of a single sheet of oceanic lithosphere that accreted at a forearc spreading ridge. In addition, we show that kinematic and paleomagnetic analysis of ophiolite belts may provide novel constraints on the kinematic evolution of accretionary orogens and the plates now lost to subduction.
An 18-month meditation training selectively improves psychological well-being in older adults
Authors: Schlosser Marco , klimecki olga , Collette Fabienne , Gonneaud Julie , Kliegel Matthias , Marchant Natalie L. , Chételat Gaël , Lutz Antoine
Published: November 2022

Objectives: As the world population is ageing, it is vital to understand how older adults can maintain and deepen their psychological well-being as they are confronted with the unique challenges of ageing in a complex and vulnerable world. Theoretical work has highlighted the promising role of intentional mental training such as meditation practice for enhancing human flourishing. However, meditation-based randomised controlled trials in older adults are lacking. We aimed to investigate the effects of meditation training on psychological well-being in older adults.Methods: The Age-Well trial (ClinicalTrials.gov: NCT02977819) randomised 137 healthy older adults to an 18-month meditation training (9-month mindfulness followed by 9-month compassion and loving-kindness training), a structurally matched active comparator (English language training), or a passive control. Well-being was measured at baseline, mid-intervention, and 18-month post-randomisation using the Psychological Well-being Scale (PWBS), the World Health Organisation’s Quality of Life (QoL) Assessment psychological subscale, and composite scores reflecting meditation-based well-being dimensions of awareness, connection, insight, and a global score comprising the average of these three meditation-based dimensions. Mixed effects models assessed between- and within-group differences in change over 18 months.Results: Meditation training was superior to English training on changes in the global score and the subscales of awareness, connection, insight, and superior to no-intervention only on changes in the global score and awareness. Between-group differences in psychological QoL in favour of meditation did not remain significant after adjusting for multiple comparisons. There were no between-group differences in PWBS total score. Within the meditation group, psychological QoL, awareness, insight, and the global score increased significantly from baseline to 18-month post-randomisation. Exploratory moderator analyses suggested that greater levels of well-being at baseline predicted smaller improvements for most well-being outcomes.Conclusion: The longest randomised meditation training conducted to date enhanced a global composite score reflecting the meditation-based well-being dimensions of awareness, connection, and insight in older adults. Future research is needed to delineate the cognitive, affective, and behavioural factors that predict responsiveness to meditation and thus help refine the development and efficacy of tailored meditation-based interventions.
Lovingkindness Meditation and Navigating Harm: a Community-Engaged Qualitative Study with Diverse Meditators during COVID-19
Authors: Thompson-Lastad Ariana , hussein shah noor , Harrison Jessica , Zhang Xiaoyu , Ikeda Mushim P. , Chao Maria , Adler Shelley , Weng Helen
Published: November 2022

Objectives: Inclusive research is needed to understand how contemplative practices are used by people across a range of identities. Lovingkindness meditation (LKM) may be particularly relevant for people to committed to equity and justice because of the social nature of the practice. Using community-based participatory research and an intersectional framework, this qualitative study focuses on how people in a diverse meditation community teach and practice lovingkindness or metta meditation.Methods: In partnership between university researchers and a community-based meditation center, we conducted virtual focus groups on experiences with lovingkindness meditation during the early months of the COVID-19 pandemic. We used reflexive thematic analysis to analyze focus group data, with a member checking process. Results: 47 people participated in 6 focus groups (mean age 47; 62% LGBTQ+; 32% white, 23% Asian, 19% Black, 13% Hispanic/Latina/o, 24% multi-racial). Qualitative analysis revealed two central themes: (1) The use of skillful means to support diverse meditators’ participation in a community of practice, including adaptation to virtual-only formats during COVID-19; (2) Meditators’ use of metta to navigate harmful situations, both individual stressors and systems of oppression. Conclusions: Diverse participants in a meditation community found lovingkindness practice supportive for coping with the stress of microaggressions and structural oppression. They utilized LKM to navigate hardships caused by the COVID-19 pandemic, offer compassion to themselves and others, and cultivate the ability to hold multiple difficult emotions. Community-engaged approaches to meditation research are feasible during the COVID-19 pandemic and other times of crisis and should be used more widely.
The Process of Replication Target Selection in Psychology: What to Consider?
Authors: Pittelkow Merle-Marie , Field Sarahanne Miranda , Isager Peder Mortvedt , van 't Veer Anna Elisabeth , Anderson Thomas , Cole Scott , Dominik Tomáš , Giner-Sorolla Roger , Gök Sebahat , Heyman Tom , Jekel Marc , Luke Timothy John , Mitchell David Joseph , Peels Rik , Pendrous Rosina , Sarrazin Samuel , Schauer Jacob M. , Specker Eva , Tran Ulrich S. , Vranka Marek Albert , Wicherts Jelte M. , Yoshimura Naoto , Zwaan Rolf Antonius , van Ravenzwaaij Don
Published: November 2022

Increased execution of replication studies contributes to the effort to restore credibility of empirical research. However, a second generation of problems arises: the number of potential replication targets is at a serious mismatch with available resources. Given limited resources, replication target selection should be well-justified, systematic, and transparently communicated. At present the discussion on what to consider when selecting a replication target is limited to theoretical discussion, self-reported justifications, and a few formalized suggestions. In this Registered Report, we proposed a study involving the scientific community to create a list of considerations for consultation when selecting a replication target in psychology. We employed a modified Delphi approach. First, we constructed a preliminary list of considerations. Second, we surveyed psychologists who previously selected a replication target with regards to their considerations. Third, we incorporated the results into the preliminary list of considerations and sent the updated list to a group of individuals knowledgeable about concerns regarding replication target selection. Over the course of several rounds, we established consensus regarding what to consider when selecting a replication target.
Commonalities Between Mind Wandering and Task Switching: An Event-Related Potential Study
Authors: Wong Yi Sheng , Pat Narun , Machado Liana
Published: November 2022

Previous research has established that mind wandering does not necessarily disrupt one’s task-switching performance. Here we tested, using event-related potentials (ERPs), the possibility that mind wandering during task switching does not disrupt switching-related mental processes but rather promotes them. In the current study, a final sample of 16 young adults performed a task-switching paradigm while electroencephalography was continuously recorded; mind wandering was assessed via thought probes at the end of each block. Consistent with previous research, behavioral results indicated that switching performance was not disrupted by mind wandering (evidenced by response times). The ERP results showed that at the Pz electrode, P300 amplitude was higher for self-reported mind-wandering switch trials than self-reported on-task switch trials, thus opposing the typical pattern of P300 attenuation during periods of mind wandering relative to on-task episodes. Considering that increased P300 amplitude during higher-order switch trials (e.g., response rule switching) may reflect the implementation of new higher-order task sets/rules, the current findings seem to indicate similar, yet distinguishable, executive control processes underlie mind wandering and task switching, providing further evidence in favor of a role for switching in mind wandering.
Анализ теоретических идей Д.Х. Джексона и их значение для современного подхода к афазиям
Authors: Elisaveta Markashova , А.А. Скворцов
Published: November 2022

Данная работа посвящена анализу теоретических идей английского невролога Д.Х. Джексона. Нами были рассмотрены как общие идеи этого автора о строении и функционировании нервной системы, так и, в особенности, его подход к анализу речевых расстройств - афазий. Выделялись те положения Д.Х. Джексона, которые, по нашему мнению, актуальны и для современных подходов к речевым расстройствам. В этом ключе подробно рассматривались идеи о качественном различении функций мышления и речи, уровневом строении речевой функции, процессе пропозиционирования и других. Также нами было отмечено формирование таких понятий как "психологическое средство" и "психологический способ" в контексте анализа речевой функции, которые впервые начали оформляться в подходе Д.Х. Джексона. В работе показана современность тех проблем, которые Д.Х. Джексон видел в современных ему подходах к афазиям, а также актуальность и для нашего времени тех решений, которые он предлагал, но которые, как нам кажется, мало рефлексируются современным научным сообществом.