bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of association between molecular marker expression on tumor and immunocompetent cells and sensitivity to adjuvant and neoadjuvant therapy of bladder cancer
Authors: Zaborskiy I. N. , Ivanov S. A. , Mushkarina T. Yu. , Karyakin O. B. , Kuzmina E. G. , Safiullin K. N. , Chaykov V. S. , Troyanov A. V. , Dementiev I. O. , Kasymov M. R. , Demyashkin G. A.
Published: July 2019

Use of immunotherapy in treatment of muscle-invasive bladder cancer remains the most promising method in case of impossibility of chemotherapy with cisplatin or progression during cisplatin treatment. This approach is the method of choice and can prolong patient’s life. In particular, use of checkpoint inhibitors allows to obtain effective treatment of bladder cancer. However, to prescribe immunotherapeutic medication, patient must have point of application for these drugs. Individualized approach will allow to increase treatment effectiveness and disease prognosis while maximally improving the quality of life.
Statistics of malignant tumors of urinary and male urogenital organs in Russia and the countries of the former USSR
Authors: Axel E. M. , Matveev V. В.
Published: July 2019

The study objective is to analyze incidence of cancer morbidity and morality in Russia and some former Soviet states. Prevalence of urinary and male urogenital organs cancer continues to grow. Morphological verification of the diagnosis varied from 58.5 % (at bladder cancer in Tajikistan) up to 93.7 % (in Russia), at a prostate cancer the maximum values are registered in Russia, Belarus and Ukraine (91–99 %); at kidney cancer in Russia, Belarus and Uzbekistan (84 %). In 2012–2017 years the increase of kidney cancer incidence in Russia (in men) made 13.8 %; at a prostate cancer, growth of the standardized rates is registered in all provided countries of the former USSR (except Kyrgyzstan). Decrease in incidence rates of bladder cancer is registered at men in Belarus, Moldova, Kazakhstan, Armenia and Kyrgyzstan. In Russia and Belarus mortality rates of kidney and a bladder cancer decreased; at a prostate mortality rate for the 5 anniversary is stable in Belarus; its insignificant increase was in Russia (for 3.4 %). The increase of penis cancer incidence in Russia was 24 %. The ratio of the maximum and minimum incidence rates among regions of Russia reached 16-fold sizes (at penis cancer) and 6-fold sizes – at testis tumours. Above, than on average in Russia (2.1 per 100 thousand, male population) testis cancer cases in Belarus (3.0 per 100 thousand). In 2012–2017 the increase of testis cancer incidence in Russia was 16.7 %.
Resolution on the results of the Expert Council on the treatment of advanced and metastatic clear cell renal cell carcinoma
Authors: Editorial Article
Published: July 2019

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Evaluation of quality of life of patients after surgical treatment of kidney cancer
Authors: Popov S. V. , Guseynov R. G. , Orlov I. N. , Skryabin O. N. , Davydov A. V. , Barkhitdinov R. S. , Katunin A. S. , Mirzabekov M/ M.
Published: July 2019

Background. Restoring the quality of life of patients to a level comparable to that of practically healthy people is the most important task of medicine in general. At this stage of development of science, the main goal in the treatment of malignant diseases remains the preservation of life. However, now in oncological practice, methods whose potential allows not only to preserve life as such, but also to ensure the high quality of this life in all its manifestations, are acquiring greater and greater significance.

The objective of the study is to compare the quality of life of persons with localized kidney cancer in the early and late periods after surgical treatment by radical nephroectomy and laparoscopic resection of renal tissue.

Materials and methods. A questionnaire survey using SF-36 (Short Form-36), designed for a comprehensive assessment of the quality of life associated with health.

Results. The quality of life of patients with localized kidney cancer before treatment is reduced due to a number of physical and mental nature, limiting labor, domestic and social activity and causing a feeling of dissatisfaction with their lives in general. These problems are disorders of physical, social and emotional functioning, physical pain, deterioration of general and mental health, limitations of role functioning due to physical and emotional state. After surgical treatment with laparoscopic resection, complete satisfaction of patients with the quality of their life was achieved during the first 1–3 postoperative months; after radical nephroectomy – not earlier than 1–3 years.

Conclusion. One of the advantages of laparoscopic resection over radical nephroectomy is a higher quality of life of patients in the early and late periods after the intervention.
The validation results for APhiGT algorithm for clarification of prostate cancer staging before treatment (first step)
Authors: Sergeeva N. S. , Skachkova T. E. , Marshutina N. V. , Nushko K. M. , Shevchuk I. M. , Nazirov M. R. , Pirogov S. A. , Yurkov E. F. , Gitis V. G. , Alekseev B. Ya. , Kaprin A. D.
Published: July 2019

Background. We have previously described an algorithm APhiGT (Age, Prostate Health index, Gleason score, TNM stage) for staging of prostate cancer (PC) before treatment. The algorithm was developed by logistic regression on an educational selection (ES) of 337 PC cases. The algorithm includes data about the age of patients, the levels of total prostate-specific antigen (PSA), free PSA, [-2]proPSA and the ranked data of the Gleason score (by biopsy results) and T (by TNM).

Objective. Validation of APhiGT on the validation selection (VS) of 83 PC cases was carried out in this work.

Materials and methods. ROC analysis was performed in ES and VS.

Results and сonclusion. It is established that area under the curve (AUC), characterizing the ability to divide clinically significant subgroups of patients (Gleason score <7 vs. Gleason score ≥7, рТ2 vs. рТ3, localized indolent PC vs. localized aggressive PC) for APhiGT both in ES and VS was significantly higher than AUC for total PSA, %[-2]proPSA in free PSA and prostate health index. At the same time, in all clinical subgroups of patients AUC for VS was lower than AUC for ES, which may be due to a significantly smaller size of VS compared to ES.
Modern drug therapy of prostate cancer through the example of Moscow
Authors: Polyakova K. I. , Fisun A. G. , Govorov A. V. , Krysanova V. S. , Andreev D. A. , Ermolaeva T. N. , Andreyashkina I. I. , Zavyalov A. A. , Davydovskaya M. V. , Kokushkin K. A.
Published: July 2019

Background. The average annual increment (5,09 %) of the prostate cancer (PC) incidence was highest across male oncological diseases registered in Russia from 2007 to 2017. 4643 new cases of PC were diagnosed in Moscow in 2017. As of 1st January 2018, the total number of living males with PC registered within Moscow healthcare system was 31,567.

The study objective was to obtain the structure of factual costs related to medicine therapy of PC covered by the budget funds of the Moscow Healthcare Department in 2016–2017, that would help to further improve the system of subsidized drug provision for Moscow residents.

Materials and methods. Using data from the information database of the Center for Medicine Provision of the Moscow City Department of Healthcare the following parameters were determined: total sum of expenses on drug purchase, mean treatment cost per 1 patient, number of patients receiving therapy, number of prescriptions, number of prescribed drug packs, mean pack cost, and others. The analyzed medicines were classified based on pharmacological and clinical groups. Costs for each class of therapies were studied.

Results. During studied period (2016–2017), the most funds in Moscow were spent on abiraterone and goserelin. In 2016–2017, the amounts of prescribed packs were highest for androgen deprivation therapy: luteinizing hormone-releasing hormone agonists – goserelin and buserelin. In the group comprising 10 therapeutic regimens associated with highest costs, the percentages of costs for hormonal therapy and chemotherapy were respectively as following: 80 % and 16 % in 2016 and 75 % and 23 % in 2017. In the simplified model of costs associated with androgen deprivation therapy and treatment of metastatic castration-resistant PC without consideration of androgen deprivation therapy constituted 39 % and 61 % in 2016 and 36 % and 64 % in 2017. In the population of patients with prostate cancer, zoledronic acid, abiraterone, docetaxel, cabazitaxel were the most used medications in 2017 and the rate of enzalutamide usage was lowest.

Conclusion. The highest costs are associated with treatment of metastatic castration-resistant PC. There is a growing necessity for improvement of funds spending on medications for patients with castration-resistant PC. This improvement could be achieved through development of medical methodologies that facilitate the selection of the most cost-effective approaches for early diagnosis and treatment.
Bases para la elaboración de un diccionario español-árabe de locuciones verbales (DILVEA)
Authors: Boughaba Mohammed
Published: July 2019

En el ámbito de la fraseografía español-árabe es más que notable la falta de diccionarios que recojan las unidades fraseológicas (UFS) del español con sus equivalentes en árabe y viceversa. Motivados por el deseo de llenar este vacío, procuraremos, en esta contribución, sentar las bases para la elaboración de un diccionario semibilingüe español-árabe de una de las clases de UFS más prototípicas: las locuciones. Es más, este trabajo pretende ser más específico al tratar un subtipo de las mismas: las locuciones verbales (LV). Basándose en los logros de la fraseología, la fraseografía y la traducción, la presente propuesta pretende abordar los distintos aspectos que intervienen en la descripción lexicográfica de esta clase de fraseologismos.
Estudio, tratamiento lexicográfico y fuentes del Diccionario comercial de Domingo Gildo y Charles Le Touzé
Authors: García Aranda María Ángeles
Published: July 2019

En el contexto de las transformaciones en el comercio nacional e internacional que se producen en la segunda mitad del siglo XIX, se publica el Manuel de correspondance commerciale en espagnol et en français (1857-1859) de Domingo Gildo y Charles Le Touzé. Este artículo presenta el contenido de la obra, explica la tradición en la que se incluye y, especialmente y dada su originalidad, aporta un estudio del tratamiento lexicográfico del Diccionario comercial que reúne.
Dos modelos pedagógicos con y en la naturaleza
Authors: Cruz Orozco José Ignacio
Published: July 2019

Este artículo analiza la aparición de los campamentos juveniles, uno de los nuevos mecanismos de intervención pedagógica no formal, en los cuales se plasmaron los cambios del rol social experimentado por la juventud en las sociedades europeas durante las primeras décadas del siglo XX. Aunque el contacto con la naturaleza resultaba innovador, hubo diversos modelos de aplicación con orientación dispar. Este trabajo se centra en las dos más relevantes que se dieron en la España de la primera mitad del siglo XX. El primero puesto en marcha por Los Exploradores de España, la organización que introdujo el escultismo en nuestro país. El segundo planteado por el Frente de Juventudes, la entidad responsable de la política de juventud durante el franquismo. Tras un estudio de sus principales características y del discurso en que se sustentaban, concluimos que el primero desarrolló un programa formativo con la naturaleza, en el cual se pueden identificar interesantes elementos conservacionistas, mientras que en la propuesta falangista, el campamento fue más bien un medio en la naturaleza para inculcar el ideario nacional-sindicalista.
«Cada Casa da Criança que se abre, corresponde a uma enfermaria que se fecha». Gerar, criar e educar no Portugal do Estado Novo
Authors: Gomes Ferreira António , Mota Luís
Published: July 2019

A análise centra-se no programa das Casas da Criança enquadrado na obra social e educativa edificada pela ação, sucessiva, das Juntas Geral do Distrito de Coimbra, da Província da Beira Litoral e Distrital de Coimbra, lideradas por Fernando Bissaya Barreto, entre 1927 e 1974. Discute-se o programa pelo viés da inovação em educação enquanto introdução do novo e a reconfiguração das relações com o saber e o poder. Interpelamos um conjunto multivariado de fontes arquivísticas, e.g., processos de admissão às Casas da Criança, os livros de atas, plantas e alçados, fotografias e um conjunto de trabalhos elaborados por estagiárias. Das fontes publicadas destacam-se a imprensa escrita e algumas publicações contemporâneas dos acontecimentos. O corpus documental foi sujeito ao método crítico e à análise de conteúdo e recorreu-se à triangulação de fontes para uma leitura mais totalizante. Obteve-se uma compreensão complexa da realidade educacional, captando dimensões de inovação educativa e dos seus limites.
Friluftsliv, a paixón polo retorno á Natureza
Authors: Miró Laiz Lidia
Published: July 2019

Documentos: Friluftsliv, a paixón polo retorno á Natureza
Miguel Ángel Martín Sánchez; Tamar Groves; Joaquim Pintassilgo; Jorge Cáceres-Muñoz: Tradición e innovación en la educación europea en los siglos XIX-XX: Los casos de España y Portugal
Authors: Pessoa Ana Maria
Published: July 2019

Resenha de livro: Miguel Ángel Martín Sánchez; Tamar Groves; Joaquim Pintassilgo; Jorge Cáceres-Muñoz (2018). Tradición e innovación en la educación europea en los siglos XIX-XX: Los casos de España y Portugal.
Ann Taylor Allen: The Transatlantic Kindergarten. Education and Women’s Movements in Germany and the United States
Authors: Otero Urtaza Eugenio Manuel
Published: July 2019

Recensión de libro: Ann Taylor Allen (2017). The Transatlantic Kindergarten. Education and Women’s Movements in Germany and the United States.
Tamiz neonatal y fenilcetonuria
Authors: Vela-Amieva Marcela , Ibarra-González Isabel , Belmont-Martínez Leticia
Published: July 2019

La fenilcetonuria (PKU) es el más paradigmático de los errores innatos del metabolismo. Su descubrimiento por Fölling en 1934 marcó el inicio de las neurociencias al explicar por primera
vez el origen bioquímico del retraso mental
Анализ готовности металлургического предприятия к «Индустрии 4.0» и стратегия внедрения цифровых решений
Authors: Фролов Владислав Генрихович , Трофимов Олег Владимирович , Мартынова Татьяна Сергеевна
Published: July 2019

Целью статьи является повышение качества реализации стратегии цифровой трансформации производственного предприятия металлургической промышленности. В ходе исследования был проведен анализ уровня готовности развития металлургического предприятия к цифровой трансформации. В результате определен уровень цифровой трансформации, выявлены проблемные элементы и предложена пошаговая стратегия внедрения основных компонентов концепции «Индустрия 4.0».
Управление инновационной системой региона (на примере Нижегородской области)
Authors: Захарова Екатерина Васильевна , Митякова Ольга Игоревна
Published: July 2019

В условиях нестабильной экономической ситуации на международной арене необходимо поддерживать развитие малого и среднего бизнеса в регионе, что позволит повысить устойчивость региональной экономики, повысить инновационный климат, обеспечить социальное и инновационное развитие. В статье рассматривается роль информационной системы в управлении инновационной системой региона. Проанализированы проблемы по регулированию инновационной деятельности, даны рекомендации по управлению инновационной системой региона, также обозначена роль информационной поддержки в сфере инноваций для эффективного управления инновационными системами в регионе.
В статье представлены рекомендации, в основе которых легло целеполагание на создание единой информационной среды для систем управления.
Цифровизация экономики на примере банковской системы
Authors: Боркова Елена Аркадьевна , Осипова Кристина Андреевна , Светловидова Елизавета Валентиновна , Фролова Елена Викторовна
Published: July 2019

Актуальность исследования цифровизации экономики России обусловлена снижением темпов экономического роста и потребностью в изменении некоторых морально устаревших аспектов экономики. Статья фокусируется на вопросах цифрового развития экономики страны. Особое внимание отводится банковскому сектору и цифровизации именно в этой отрасли. В результате исследования показаны как положительные, так и отрицательные эффекты такого рода модернизации. Несомненно, важным компонентом цифровизации стоит отметить такую технологичную индустрию экономики, как финтех. В статье проанализирована роль этой отрасли, а также то, как она существует в совокупности с банковскими организациями. Рассматриваются этапы цифровизации банковского сектора и пять общих тенденций развития цифровой экономики РФ, выделенные авторами. Результатом исследования является оценка значимости цифровой трансформации для экономики государства.
Modularidad y prefabricación abovedada. Colombia como germen de una tradición moderna. La experiencia bogotana y su influencia en Latinoamérica
Authors: Medina Juan Manuel , García Julián , Rodríguez Juan Antonio
Published: July 2019

In the 1950s, Colombian architects Álvaro Ortega and Francisco Pizano designed highly original dwellings by following advanced criteria in modularity and industrialization that were in line with the postulates of this period. Their approaches are reflected in a large number of constructions that were later-built throughout Latin America. Additionally, this article demonstrates how Pizano’s house was an inspiration for Le Corbusier and then later for Latin American domed dwellings in the 1950's, 60's, and 70's. It, therefore, demonstrates the influence of architecture from Bogota in terms of this structural typology (the prefabricated dome) as both an antecedent and consequence of this type of building.
Mayo del 68, se levantan las Torres del Parque en Bogotá. Conversación sobre las entrañas del proyecto de Rogelio Salmona
Authors: Urrea Uyabán Tatiana
Published: July 2019

The El Parque Housing Estate —known as Torres del Parque—, located in Bogotá, was conceived by the architect Rogelio Salmona (Paris, 1929-Bogotá, 2007) at the beginning of the 1960s. There were years of uncertainty, of doubt, of successive testing until he found the right form. In May 1968, the construction of Las Torres Began thanks to the extraordinary dialogue that was later known as the executive triangle: architect and designer, Rogelio Salmona, Italian engineer Doménico Parma, and the architect and project coordinator Urbano Ripoll.
Identification of clinical dermatophyte isolates obtained from Iran by matrix-assisted laser desorption/ionization time-offlight mass spectrometry
Authors: Hedayati Mohammad Taghi , Ansari Saham , Ahmadi Bahram , Taghizadeh Armaki Mojtaba , Shokohi Tahereh , Abastabar Mahdi , Er Halil , Özhak Betil , Öğünç Dilara , Ilkit Macit , Seyedmousavi Seyedmojtaba
Published: July 2019

Background and Purpose: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is widely used to discriminate among pathogenic microorganisms in clinical laboratories. The aim of this study was to assess the utility of MALDI-TOF MS in the routine identification of clinical dermatophyte isolates obtained from various geographical regions of Iran. Materials and Methods: A total of 94 isolates, including Trichophyton interdigitale (n=44), T. rubrum (n=40), T. tonsurans (n=4), Microsporum canis (n=4), and Epidermophyton floccosum (n=1), were analyzed in this study. The identity of each isolate was determined by polymerase chani reaction amplification and sequencing of the internal transcribed spacer (ITS) region of nuclear-encoded ribosomal DNA and also MALDI-TOF MS. The obtained data by molecular approach were compared with MALDI-TOF MS. Results: The MALDI-TOF MS led to the identification of 44 (47%) isolates at the species level by generating the spectral score values of ≥ 2.0. However, there was not sufficient agreement between the results of the molecular-based ITS identification methods and MALDI-TOF MS in the species identification of 16 (17%) isolates. The Bruker Daltonics database was also not able to identify protein spectra related to 12 isolates (13%), including T. interdigitale (n=5), T. rubrum (n=4), M. canis (n=2), and T. tonsurans (n=1). Conclusion: According to the results, the utility of MALDI-TOF MS as a routine diagnostic tool for the accurate and reliable identification of dermatophytes can be justified whenever the protein spectra of a large set of worldwide clinical isolates are included in the commercial libraries. In addition, MALDI-TOF MS can be alternatively used to construct an in-house reference database.
Onychoscopic evaluation of distal and lateral subungual onychomycosis: A cross-sectional study in Lebanon
Authors: Maatouk Ismael , Haber Roger , Benmehidi Nazim
Published: July 2019

Background and Purpose: The aim of this study was to evaluate the onychoscopic patterns associated with distal lateral subungual onychomycosis (DLSO) in Lebanon. Materials and Methods: The present study was conducted on 45 patients with clinical DLSO attending two dermatology clinics in Beirut, Lebanon, between January 2018 and April 2018. The patients were subjected to dermoscopy to identify the onychoscopic patterns. Results: The DLSO was predominantly associated with white, yellow, and brown color changes (P<0.05). Dermoscopic patterns of longitudinal striae (n=31; 68.75%), spiked pattern (n=25; 55.5%), and jagged pattern (n=25; 55.5%) were significantly correlated with DLSO (P<0.001). Our findings are in accordance with five previous reports in which dermoscopic findings are discussed in onychomycosis. Conclusion: It is recommended to perform further studies on homogeneous groups with different clinical subtypes of onychomycosis including patients with suspected traumatic onycholysis or other nail diseases. Identification of onychoscopic patterns would offer the clinicians a quick, simple, and complementary tool for the diagnosis of onychomycosis.
Causas y efectos del patronazgo en municipios de Chile, 2008-2012
Authors: Navia Patricio , Mimica Nicolás
Published: July 2019

En este artículo se analiza la presencia de vínculos clientelares y patronazgo en Chile como método de movilización electoral. Para ello se han estudiado las 345 comunas de dicho país entre 2008 y 2012. Con datos de gasto en personal y de empleo municipal, se han evaluado las causas del patronazgo y sus efectos en la participación y desempeño electoral. De ese modo se ha concluido que los alcaldes de la Unión Demócrata Independiente (udi) tienen una mayor tasa de gasto en personal municipal, que los municipios controlados por el Partido Por la Democracia (ppd) tienen las mayores tasas de empleo municipal y que el empleo municipal se utiliza como estrategia de movilización electoral.
Política internacional subnacional y su medición: debates y propuesta para su abordaje en el caso de los municipios de Argentina
Authors: Calvento Mariana
Published: July 2019

El presente artículo analiza las relaciones internacionales de los actores subnacionales. En primer lugar, se concentra en los gobiernos locales y realiza un recorrido sobre los principales enfoques utilizados, estableciendo una conceptualización que se ajusta a la realidad de los gobiernos municipales de la Argentina a través de la política internacional subnacional. En segundo, propone una herramienta de medición para establecer parámetros sobre el perfil y la trayectoria del accionar externo de los gobiernos locales denominada índice de participación internacional. Así, el artículo busca contribuir en la temática aportando un enfoque desde el cual abordar la participación internacional subnacional.
The Disprove of the Komlos Conjecture
Authors: Brahim Belhaouari Samir , AlQudah Randa
Published: July 2019

Komlos conjecture is about the existing of a universal constant K such that for all dimension n and any collection of vectors V 1 → ,…, V n → ∈ ℝ n with V . → 2 ≤1 , there are weights ε i ∈{ −1,1 } in such that ∑ i=1 n ε i V i → ∞ ≤K( n )≤K. In this paper, the constant K( n ) is evaluated for n≤5 to be K( 2 )= 2 , K( 3 )= 2 + 11 3 , K( 4 )= 3 , and K( 5 )= 4+ 142 9 . For higher dimension, the function f( n )= n− lo g 2 ( 2 n−1 /n ) is found to be the lower bound for the constant K( n ), from where it can be concluded that the Komlos conjecture is false i.e., the universal constant K does not exist because of lim n→∞ K( n )≥ lim n→∞ log( n )−1 =+∞.
A Survey of Attacks Against Twitter Spam Detectors in an Adversarial Environment
Authors: Imam Niddal
Published: July 2019

Online Social Networks (OSNs), such as Facebook and Twitter, have become a very important part of many people’s daily lives. Unfortunately, the high popularity of these platforms makes them very attractive to spammers. Machine-learning (ML) techniques have been widely used as a tool to address many cybersecurity application problems (such as spam and malware detection). However, most of the proposed approaches do not consider the presence of adversaries that target the defense mechanism itself. Adversaries can launch sophisticated attacks to undermine deployed spam detectors either during training or the prediction (test) phase. Not considering these adversarial activities at the design stage makes OSNs’ spam detectors prone to a range of adversarial attacks. This paper thus surveys the attacks against Twitter spam detectors in an adversarial environment. In addition, a general taxonomy of potential adversarial attacks is proposed by applying common frameworks from the literature. Examples of adversarial activities on Twitter were provided after observing Arabic trending hashtags. A new type of spam tweet (Adversarial spam tweet), which can be used to undermine deployed classifier, were found. In addition, possible countermeasures that could increase the robustness of Twitter spam detectors against such attacks are investigated.
Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance
Authors: Fousteri Georgia
Published: July 2019

Viral infections make a natural part of our existence. They can affect us in hundreds of different ways that are the result of the interaction between the viral pathogen and our immune system. Most times the resulting immune response is beneficial for the host. The pathogen gets cleared protecting our vital organs with no other consequences. Sometimes, things go wrong and the reaction of our immune system against the pathogen causes organ damage (immunopathology) or leads to autoimmune disease. To date, there are several mechanisms for virus-induced autoimmune disease, including molecular mimicry and bystander activation, in support of the “fertile field” hypothesis. On the flip side, viral infections have been associated with protection from autoimmunity through mechanisms that include Treg invigoration and immune deviation, in support of the “hygiene hypothesis”. Infection with lymphocytic choriomeningitis virus (LCMV) is one of the prototype viral systems showing that the interaction of our immune system with the viruses can either accelerate or prevent autoimmunity. Studies using LCMV have helped conceive and establish several concepts that we today know and explain how viruses can lead to autoimmune activation or induce tolerance. Some of the most important mechanisms established in LCMV are described in this short review.
Assessment of Probiotic Potential and Antagonistic Characteristics of Bifidobacterium bifidum Isolated from Infant Feces against Enteropathogenic Escherichia coli
Authors: Ashraf Muhammad , Kanwal Rehana , Khan Iahtasham , Munir Sadia , Aslam Rizwan , Ali Sultan , Abbas Ali , Ali Mubarik , Abbas Ghazanfar
Published: July 2019

Enteropathogenic microorganisms like Escherichia coli cause severe intestinal problems by disrupting the gut homeostasis. The live microorganisms, when given in adequate quantities provide several beneficial effects to the host are known as probiotics. One of the pronounced benefits conferred by probiotic is to antagonize the growth of enteropathogens competing for adherence to the intestinal epithelium. Bifidobacterium is the major genera of human especially infant are intestinal microbiota. In current study, Bifidobacterium bifidum was isolated from the infant stools and probiotic potential was assessed using prescribed tolerance tests against low pH, gastric juices and bile salts. Anti-infectious activity of probiotic Bifidobacterium bifidum against enteropathogenic E. coli was checked both in vitro and in vivo using agar well diffusion assay and mice model respectively. Mice feces were evaluated for both Bifidobacterium bifidum and E. coli counts in all groups and analyzed statistically. In vitro results showed Bifidobacterium bifidum possess marked antibacterial activity against E. coli. There was significant decrease in enteropathogenic E. coli burden in the mice group fed with Bifidobacterium bifidum before and after challenge. In conclusion, the endogenous Bifidobacterium bifidum have excellent probiotic potential and can be used prophylactic and treatment option against enteropathogens.
Analisis Kestabilan Model Mangsa Pemangsa dengan Pemanenan Ambang Batas pada Populasi Pemangsa
Authors: Yusrianto Yusrianto , Toaha Syamsuddin , Kasbawati Kasbawati
Published: July 2019

Abstrak Penelitian ini mengkaji model satu mangsa dan satu pemangsa yang saling berkompetisi. Fungsi predasi dari pemangsa diasumsikan menggunakan fungs1 respon Holling tipe II. Dengan asumsi bahwa adanya kompetisi intraspesifik pada popuasi pemangsa serta dilakukan pemanenan ambang batas pada popuasi pemangsa. Pada model tersebut dilakukan analisis tentang syarat kewujudan dan kestabilan titik keseimbangan interior. Analisis kestabilan titik keseimbangan interior dilakukan dengan metode linearisasi dan dengan memperhatikan nilai eigen dari matriks Jacobi yang diperoleh. Terdapat sepuluh titik kesetimbangan yang diperoleh pada model, satu diantaranya dapat dinterpretasikan. Titik tersebut dinyatakan stabil asimtotik. Berdasarkan hasil anasis menggunakan beberapa parameter, diketahui bahwa ada suatu waktu pemanenan ambang batas harus dihentikan karna sudah tidak memenuhi syarat kriteria ambang batas yang telah ditentukan.Kata kunci : Model mangsa pemangsa, Pemanenan ambang batas, Titik kesetimbanganAbstract This study examines the model of one prey and one predator who mutates each other. The predation function of predators is assumed to use the Holling type II response function. Assuming that the existence of intraspecific competition in predatory population and theshold harvesting for predatory population is carried out. In this model, an analysis of the actual conditions and stability of the interior balance point is carried out. Analysis of the interior stability balance points was carried out by linearization method and by taking into account the eigenvalues of the Jacobian matrix obtained. There are ten equilibrium points of engagement obtained on the model, one of which can be interpreted. This point is stated as asymptotically stable. Based on the results of analysis using several parameters, it is known that there is a time when harvesting the threshold must be stopped because it has not fulfill the specified criteria for threshold.Keyword : Prey-predator model threshold harvesting, equibrium point
Analisis Kestabilan Model SEIR Penyebaran Penyakit Campak dengan Pengaruh Imunisasi dan Vaksin MR
Authors: Sihotang Willyam Daniel , Simbolon Ceria Clara , Hartiny July , Tindaon Desrinawati , Sinaga Lasker Pangarapan
Published: July 2019

Measles is a contagious infectious disease caused by a virus and has the potential to cause an outbreak. Immunization and vaccination are carried out as an effort to prevent the spread of measles. This study aims to analyze and determine the stability of the SEIR model on the spread of measles with the influence of immunization and MR vaccines. The results obtained from model analysis, namely there are two disease free and endemic equilibrium points. If the conditions are met, the measles-free equilibrium point will be asymptotically stable and the measles endemic equilibrium point will be stable. Numerical solutions show a decrease in the rate of spread of measles due to the effect of immunization and the addition of MR vaccines.
ETNOMATEMATIKA BUDAYA JAWA : INOVASI PEMBELAJARAN MATEMATIKA DI SEKOLAH DASAR
Authors: Rudyanto Hendra Erik
Published: July 2019

Innovation in learning mathematics needs to be done so that the learning objectives of mathematics can be achieved effectively. One of the innovations that can be done is to utilize Javanese cultural products in learning mathematics. Besides being able to learn mathematics well, students can also get to know their culture which is slowly being forgotten. This study aims to describe the results of ethnomatatics exploration of Javanese culture that can be utilized in mathematics learning. The type of research used is exploration with an ethnographic approach. The results of the study show that there are many Javanese cultural products that have the potential for learning mathematics such as cultural products in the form of artifacts, traditional foods, traditional games, batik, and so on. If the Javanese cultural product can be utilized in mathematics learning well, it will create meaningful learning for students.
Desember 2016 EFEKTIVITAS PELAYANAN PELAPORAN SPT MASA BAGI WAJIB PAJAK ORANG PRIBADI DAN BADAN MELALUI LAYANAN DRIVE THRU (STUDI PADA KPP PRATAMA SINGOSARI)
Authors: Jinan Maya Zukhrifatil , Haryadi Bambang , Harwida Gita Arasy
Published: July 2019

The purpose of this research is to identifity the effectiveness of monthly tax return reporting activities through the drive-thru
service in KPP Pratama Singosari. The effectiveness was identified by comparing the objective of the drive thru service
and its achievment since it is enacted. This research used qualitative descriptive method and depth interview, observation
and documentation as data collecting method. The results this study indicates that the drive thru service is generally
effective, however, it does not give asignificant effect for the KPP’s service in term of the monthly tax return reporting
service.
MENINGKATKAN KEPATUHAN DAN PENERIMAAN PAJAK MELALUI WITHHOLDING TAX SYSTEM
Authors: Darmayasa I Nyoman , Aneswari Yuyung Rizka , Yusdita Elana Era
Published: July 2019

The research aimed to understand deeply about withholding tax system in Indonesia and propose taxation strategy to maximize withholding tax according to self assessment system. The research use interpretive paradigm with literature method approach. The result of the research indicate that first, tax compliance in Indonesia is still low category so it need efforts to improve. Second, with withholding tax system will assurance due tax payment because tax taker is more discipline to cut tax for tax payer. Third, withholding tax system can control effectively and efficiently to minimize examination object not for personal tax payer but for work or income giver. Fourth, through the withholding tax system, tax payers would cut taxes when the conditions of high economic capacity. Fifth, several proposals to improve the maximization WHT include expanding the tax base and direct tax cuts were not final is still possible into the final tax in the scheme of withholding tax, giving rewards to a third party who is disciplined and obedient, open access to the Direktorat Jenderal Pajak (DJP) on the banks of the effectiveness of tax policy and make the Single Identification Number (SIN) to attract new taxpayers. This study contributes to the formulation of policies Direktorat Jenderal Pajak (DJP).
Pengaruh Penganggaran Partisipatif Terhadap Budget Slack dengan Sikap sebagai Variabel Moderating
Authors: Syahrir Anggia Dini
Published: July 2019

This study examines the effects of participative budgeting to the budget slack to be moderated by the attitude. This study used a sample of 140 individuals ranging from Head of Work Unit (SKPD) and Head of the Southeast Sulawesi provincial government. The analytical method used in this study is Partial Least Square (PLS) with SmartPLS as a means of statistical tests. The results showed that participative budgeting significant negative effect on the budget slack. The higher participation in preparing the budget, budget slack generated would be lower. As for the attitude of participative budgeting strengthened the influence of the budget slack. This indicates that the participant is responsible for the task in hand in preparing the budget so the attitude is able to strengthen the influence of participatory budgeting to budget slack.
PENGARUH KOMITMEN ORGANISASIONAL, SISTEM PENGENDALIAN INTERN PEMERINTAH, DAN GAYA KEPEMIMPINAN TERHADAP KINERJA MANAJERIAL (Survey Pada SKPD Sumbawa Dan Sumbawa Barat)
Authors: Hakim Lukmanul , Asmony Thatok , Inapty Biana Adha
Published: July 2019

This study was conducted to examine the effect of organizational commitment, the internal control system of government, and the leadership style of the performance of managerial work unit area in Sumbawa and Sumbawa Regency Government of West. The sampling technique used purposive sampling. The data were analyzed using multiple linear regression method. Results based on test data analysis showed that the p-value variable organizational commitment and internal control system of government has positive influence on managerial performance. While the leadership style variable did not show any effect on managerial performance. Based on the value of the F test showed that the variables of organizational commitment, the internal control system of government and leadership style were simultaneously had positive effect on managerial performance.
DISKURSUS TAX AMNESTY MELALUI RUU PENGAMPUNAN NASIONAL (Potencial Fraud and Money Laundering Perspective)
Authors: Seputro Hanif Yusuf , Aneswari Yuyung Rizka , Darmayasa I. Nyoman
Published: July 2019

Objective of this study is to explore discourse and issues on tax amnesty, and give several feedbacks for improvement of implementation of tax amnesty.  This study employs descriptive method.  First finding of this study signify that the tax amnesty becomes one of options of the central government to achieve target of tax sector.  Second, Indonesia should learn from failure and success on implementation of tax amnesty in the prior period.  Third, RUU (draft of law) of national amnesty must be clear.  The amnesty is specific for tax.  Hence, there will be no possibility to do corruption (TIPIKOR), or even money laundry that use to be done after the corruption (TIPIKOR) is occurred.  Fourth, implementation of the tax amnesty programme should be followed by supporting policies, such as law of (UU) banking confidentiality and so on.  Fifth, tax amnesty is a policy that is expected by many parties to fix their SPT and make confession about their real tax; henceforth they will be more compliant on tax in the future.  Contribution of this study is to give positive discourse that can be used by the central government as feedback on tax amnesty policy as embodied in RUU national amnesty.
INFLUENCE OF AUDIT COMMITTEE COMPETENCE, AUDIT COMMITTEE INDEPENDENCE, INDEPENDENT COMMISSIONER AND LEVERAGE ON TAX AGGRESSIVENESS
Authors: Arismajayanti Ni Putu Ayu , Jati I Ketut
Published: July 2019

Tax is an important element in sustaining the government budget and an obligation that must be fulfilled by taxpayers, both individual and legal entity. The unfulfilled tax revenue target in Indonesia is caused by several factors. One of them is that there is an indication that company as the taxpayer of a legal entity commits tax aggressiveness. There is a difference of interest between the company and the government that causes the company to arrange a plan for reducing the cost of corporate taxes both legally and illegally. This study aims to obtain empirical evidence of the influence of audit committee competence, audit committee independence, independent commissioner and leverage on tax aggressiveness. The object in this study was manufacturing companies listed on the Indonesia Stock Exchange period 2013-2016. The sample used in this study was 176 companies selected by purposive sample by using multiple linear regression analysis technique. The results of this study indicate that the audit committee competence and independent commissioner variables have no effect on tax aggressiveness, audit committee independence has a negative effect on tax aggressiveness, and leverage has a positive effect on tax aggressiveness.
Institutional Ownership, Types of Industry, and Income Smoothing: Empirical Evidence from Indonesia
Authors: Suyono Eko
Published: July 2019

This paper aims to evaluate the influence of institutional ownership and types of industry on income smoothing in the Indonesian listed firms. Basing on the literature and using panel data approach, it examines 112 firms listed on the Indonesia Stock Exchange during 2012 to 2016 periods  (i.e., 560 observations).  By using OLS regression to test the hypotheses, the result shows that institutional ownership does not influence significantly on income smoothing practice.  Moreover, types of industry do not influence on income smoothing practices, except for consumer goods industry which influences significantly on income smoothing practice.  With regard to the company size as a control variable, the result shows that company size influences positively on income smoothing practice.  Therefore, this study contributes in providing empirical evidence on the link between institutional ownership, types of industry, and income smoothing practice in emerging market context (i.e., Indonesia).
“FRAUD” IN THE MANAGEMENT OF FUNCTIONAL LITERACY PROGRAM
Authors: Mafahir Alil , Musyarofah Siti , Prasetyono Prasetyono
Published: July 2019

The aim of this research is to identify the pattern of fraud in the management of functional literacy program. This is a descriptive qualitative research. This research employed primary data with interview, institutional document analysis, and observation as the method of data collection. The findings of this research suggest that there are some fraud patterns found in the management of functional literacy program i.e. (1) the proposal creation as an administrative formality (2) the reduction of the learning duration (3) the reduction of the tutor’s transportation fees (4) the reduction of the stationery procurement budget.
Determinan Fraudulent Financial Reporting Using Fraud Pentagon Analysis
Authors: Quraini Fidyah , Rimawati Yuni
Published: July 2019

This research aimed at knowing factors of fraudulent financial reporting using pentagon fraud analysis. This research analyzed the influence of financial target, financial stability, external pressure, institutional ownership, ineffective monitoring, quality of external auditors, change of auditors, change of directors, and number of CEO’s picture in fraudulent financial report. Sample in this research were 14 go public government companies from 2013 to 2017. Source of data in this research were secondary data in form of annual report in official website of Indonesia Stock Exchange. The examination of this research used logistic regression. The result of this study showed that the influence of external pressure expected fraudulent financial report, while financial target, financial stability, institutional ownership, ineffective monitoring, quality of external auditors, changing auditors, changing directors, and a number of CEO’s picture often did not influence the fraudulent financial reporting.
Social, clinical and psychometric factors affecting self-rated oral health, self-rated health and well-being in elders
Authors: Damaskinos Popie , Koletsi-Kounari Haritini , Mamai-Homata Eleni , Papaioannou William
Published: July 2019

Background

The study aims to explore the social influences, gradients and predictors of self-rated oral health (SROH) and self-rated health (SRH) and well-being in Greek elders.

Methods

Cross-sectional study, of elderly men and women, aged 65 years and over (N=743), in two municipalities in Greece. Descriptive and statistical analyses were performed for dentate and edentulous participants. For the association between socioeconomic exposures and binary outcomes, logistic regression was performed to estimate odds ratios and 95% confidence intervals (OR, 5% CI); levels of association and Cramer’s V were applied to calculate associations and p-values.

Results

Household income, education level and last main occupation were predictors and determinants of both SROH and self-rated health (SRH). All objective socioeconomic measures (income, education and occupation) and subjective social status (SSS) were predictors of SROH and SRH; however, the objective socioeconomic measures were not predictors of satisfaction with life (SWL). SSS was statistically significant for SROH, SRH and SWL, p<0.01.

Conclusions

Gender, municipality, long-standing illness, SSS and loneliness were predictors of SWL in the examined dentate population. For SROH and SRH, the results showed that household income less than 800 euros per month, education level, occupation and SSS were significant predictors. To the best of our knowledge, this is the first study to examine the effect of subjective and objective socioeconomic measures and find inequalities in both oral and general health and in the gradient of SROH among elderly adults in Greece.
How to reduce excessive use of health care service in medical aid beneficiaries: an economic impact of community-based case management
Authors: Kim Myung Ja , Lee Eunhee
Published: July 2019

Background

Community based case management for medical aid beneficiaries was implemented in Korea to induce rational use of medical care among the beneficiaries and stabilize the financial system. This study investigated the economic impact of community based case management on health care utilization and cost.

Methods

This study is a quantitative policy evaluation study to evaluate the impact of case management on excessive use of health care service in medical aid beneficiaries using national database.

Results

Total 1,741 medical aid beneficiaries with case management included in this study. Case management was provided to three target group, high-risk, long-term inpatient, and intensive care group. An increase in health-related quality of life (QOL) and the ability to use appropriate health care and a reduction in health care utilization and cost were observed for case management. There was no significant difference in the reduction in the total number of visiting days and the cost between the groups.

Conclusions

An increase in the health care utilization among medical aid beneficiaries has been observed due to the aging population and increase in the number of recipients. To reduce health care costs while maintaining the health status of the beneficiaries, it is necessitated to expand the targeted management.