bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi Hasil Belajar Siswa Sekolah Menengah Atas Dengan Menggunakan Web
Authors: Daulay Wan Akbar Arramadhan
Published: June 2021

Evaluasi dalam siklus pembelajaran signifikan, sehingga penggunaan penyusunan informasibernilai signifikan mendapat salah satu kolom signifikan. Penanganan informasi bernilai bagus mendapatkan rapor hasil penilaian sangat layak, selagi penyiapan informasi bernilai signifikan akan dimanfaatkan semacam pencapaian siswa mengikuti pelatihan di tempat belajar. Untuk mendapatkan konsekuensi dari penanganan informasi yang bernilai tinggi, salah satunya adalah dengan menggunakan dan menciptakan inovasi seperti yang sekarang atau seluruhnya membuat kerangka kerja penyiapan harga informasi mekanis untuk berbasis situs situasi ini, meskipun hasil yang didapat dari penanganan informasi yang lebih tepat, Menggunakan sistem elektronik berbasis situs juga bisa berfungsi dengan pameran dewan kependidikan yang mengawasi hasil nilai siswa.Motivasi paling utama dibalik pengungkapan " Perancangan Sistem Informasi Pengolahan Data Nilai Mahasiswa Berbasis Web Pada Sekolah SMK. Dengan adanya kerangka data ini maka diperlukan kerjasama baik dengan instruktur mata pelajaran, wali kelas maupun pertemuan terkait dalam penyusunan arsip evaluasi siswa secara lincah dan efektif.
KONSEP DASAR ILMU GIZI
Authors: Husain Zulfa , Nurfadillah Annisa
Published: June 2021

Ilmu gizi (nutrition science) adalahb “Ilmu yg mempelajari segala sesuatu tentang makanan dalam hubungannya dengan kesehatan optimal”. Sedangkan yang disebut sebagai makanan adalah “Bahan selain obat yang mengandung zat-zat gizi dan atau unsur-unsur/ikatan kimia yang dapat diubah menjadi zat gizi oleh tubuh, yang berguna bila dimasukkan dalam tubuh”. Dari pengertian tersebut jelaslah bahwa obat bukan termasuk makanan, dan semua suplemen yang mengandung zat gizi bisa kita kategorikan sebagai makanan. Perlu Anda ketahui bahwa pengertian gizi secara klasik atau zaman dahulu gizi hanya dikaitkan dengan kesehatan tubuh saja. Artinya yang dikatakan gizi adalah aspek yang berhubungan dengan fungsi dasar zat gizi tersebut yaitu menghasilkan energi, pertumbuhan dan pemeliharaaan jaringan, serta mengatur proses metabolisme dalam tubuh. Pada zaman modern ini pengertian ilmu gizi tidak hanya sebatas fungsi dasar zat gizi dan kesehatan saja tetapi zat gizi sudah dihubungkan dengan kemampuan kerja, produktivitas, IQ, dan status ekonomi. Tujuan ilmu gizi sendiri adalah mencapai, memperbaiki, dan mempertahankan kesehatan tubuh melalui konsumsi makanan.
PENGARUH TEKNOLOGI SISTEM INFORMASI MANAJEMEN TERHADAP PERUSAHAAN
Authors: Putra Muklas Adi
Published: June 2021

Penelitian ini bertujuan untuk mengetahui pengaruh teknologi informasi terhadap kinerja perusahaan. Seiringnya jaman , perkembangan teknologi semangkin meningkat ,salah satunya dibidang manajemen . Banyak perusahaan yang memanfaatkan teknologi informasi untuk meningkatkan produktivitasnya . Terkadang perusahaan mengontrak seseorang yang memiliki keahlian dibidang IT untuk mengembangkan produknya. Teknologi berguna untuk membantu individu dalam melakukan tugasnya , dalam organisasi banyak kita lihat manfaat sistem informasi digunakan sebaik mungkin.
Methodology for Business Report
Authors: Vuong Quan-Hoang , Ho Manh-Toan , La Viet-Phuong , Huyen Nguyen Thanh Thanh
Published: June 2021

This Methodology aims to explain the logical framework, the thought process, and the technological features that constitute our process of collecting information, analyzing data, and arriving at a conclusion.
Alfianoor Septiawan 1810111210035 Tugas Artikel Mata Kuliah Pembelajaran IPS
Authors: Septiawan Alfianoor
Published: June 2021

Tulisan ini membahas Pembelajaran IPS dalam fenomena pendidikan nasional di Era Globalisasi yang tentunya mengalami perkembangan baik itu dari metode pembelajaran, kurikulum, kualitas pendidik, dan tentunya program-program penunjang kualitas diri dari peserta didik sendiri dalam upaya menjadi warga negara yang baik sesuai seperti tujuan dari pembelajaran IPS sendiri. Terdapat beberapa fenomena yang dibahas dari karakteristik pembelajaran IPS, Pembelajaran Daring, dan juga pembelajaran yang bermakna dimana setiap pembelajaran tentu tidak hanya menyangkut pada aspek kognitif tetapi juga menunjang pada peningkatan aspek lainnya seperti afektif dan psikomotorik peserta didik sendiri. Baik dari kegiatan seperti ektrakurikuler dan juga pembelajaran dari gurunya sendiri dengan berbagai metode dan pendekatan pembelajaran yang digunakannya.
Konsep Dasar Ilmu Gizi Kesehatan Masyarakat
Authors: Inayaht Nurul
Published: June 2021

Pengertian dari ilmu gizi (nutrition science) adalah “ Ilmu yg mempelajari segala sesuatu tentang makanan dalam hubungannya dengan kesehatan optimal”. Sedangkan yang disebut sebagai makanan adalah “Bahan selain obat yang mengandung zat-zat gizi dan atau unsur-unsur/ikatan kimia yang dapat diubah menjadi zat gizi oleh tubuh, yang berguna bila dimasukkan dalam tubuh”.Makanan dan semua suplemen yang mengandung zat gizi bisa kita kategorikan sebagai makanan. Artinya yang dikatakan gizi adalah aspek yang berhubungan dengan fungsi dasar zat gizi tersebut yaitu menghasilkan energi, pertumbuhan dan pemeliharaaan jaringan, serta mengatur proses metabolisme dalam tubuh.
konsep dasar ilmu gizi
Authors: AKVIANI SHARA
Published: June 2021

Ilmu Gizi (Nutrience Science) Ilmu yang mempelajari segala sesuatu tentang makanan dalam hubungannya dengan kesehatan optimal/ tubuh. Ilmu tentang makanan, zat-zat gizi, dan substansi yang terkandung didalamnya, peran dan keseimbangannya, untuk kesehatan dan masalah kesehatan. Ilmu yang menggunakan berbagai disiplin ilmu dasar, seperti biokimia, ilmu hayat (fisiologi), ilmu penyakit (patologi), dan beberapa ilmu lainnya. Jadi untuk menguasai bagian-bagian ilmu dasar tersebut yang relevan dengan kebutuhan ilmu gizi (Ahmad,2004).
HAK ASASI MANUSIA VERSUS PIDANA MATI
Authors: Wuarlela Boni Suparto
Published: June 2021

Human Rights are the basic rights of every human being as God's creatures who are equal to one another. The application of the death penalty by the state through a court decision means that the state revokes the convict's right to life which is an unlimited human right. Therefore, its implementation must take into account the rights of the convict. The purpose of this paper is to find out whether the imposition of the death penalty for criminals is against human rights. What are the criteria for imposing the death penalty for perpetrators of crimes that do not conflict with human rights? The method used is a normative research method using secondary data. It can be concluded that the imposition of the death penalty is against human rights. However, in its application, it can be justified on the grounds of defending human rights and only for crimes that go beyond humanity and damage human civilization. The implementation of the criminal justice process must be transparent and fair.
KONSEP DASAR ILMU GIZI
Authors: Sumarlin Rudi
Published: June 2021

Gizi atau makanan di perlukan manusia untuk pemeliharaan tubuh termasuk pertumbuhan dan pergantian jaringan yang rusak akibat kerja atau kegiatan fisik. Gizi merupakan salah satu faktor yang sangat penting dalam meningkatkan kesegaran jasmani. Keadaan gizi dikatakan baik atau normal apabila terdapat keseimbangan antara kebutuhan hidup terhadap zat-zat gizi dengan makanan yang dikonsumsi, maksudnya jumlah energi dan zat gizi yang dikonsumsi tubuh sama dengan yang dibutuhkan oleh tubuh serta sama dengan energi yang dikeluarkan dari dalam tubuh.Setiap hari, disadari ataupun tidak kita tidak pernah bisa lepas dari zat gizi. Hal itu disebabkan karena setiap hari kita memerlukan makanan yang merupakan sumber zat gizi. Setiap kali kita merasakan lapar, pada saat itu kita memerlukan makanan untuk menghilangkan rasa lapar. Hampir setiap orang tahu pentingnya makanan bagi tubuh, tetapi pernahkah Anda memikirkan zat-zat apa yang terkandung dalam makanan yang Anda konsumsi serta bagaimana peranannya dalam menjaga kelangsungan fungsi tubuh Anda? Masih banyak orang yang belum mengerti dan mengenal komponenkomponen zat gizi serta kepentingannya bagi kesehatan tubuh. Setiap komponen zat gizi memiliki peran masing-masing bagi kelangsungan fungsi tubuh. Demi dapat memenuhi kebutuhan tersebut, seharusnya kita mampu mengenal jenis-jenis zat gizi yang diperlukan sehingga kita dapat mengonsumsi makanan secara tepat. Oleh karena itu, melalui paper ini penulis akan memaparkan materi mengenai konsep dasar ilmu gizi.
The Air in the Cabin of Passenger Aircraft Is Not as Good As Is Often Assumed - Backgrounds, Possible Solutions and Their Implementation
Authors: Scholz Dieter
Published: June 2021

Fume or smoke events have already been observed on many flights of large passenger aircraft. These events can be explained by sudden failures of seals on the bearings of jet engines, which results in pyrolized engine oil to reach the passenger cabin. But there are also many other ways in which cabin air can be contaminated. Contamination can also be caused by hydraulic or deicing fluid. Pilots, cabin crew and passengers have become ill from such singular events as they themselves report and as confirmed by medical professionals. But even without having ever experienced such a single event, pilots and cabin crew have fallen ill. This could be explained by the small amounts of oil that regularly leak from the seals.
In pancreatic ductal adenocarcinoma, differential expression of the methyltransferases METTL1, METTL6, and METTL10 is linked to a worse overall survival rate
Authors: P Rucha
Published: June 2021

PDAC (pancreatic ductal adenocarcinoma) is one of the worst malignancies in men. We used a public datasetof resected tumors from 79 individuals with PDAC to undertake global differential gene expression analysis(1). We discovered that methyltransferase-like 6 and methyltransferase-like 10, METTL6 and METTL10, wereamong the most differentially expressed genes transcriptome-wide and that their expression was significantlyassociated with poorer survival when we compared the transcriptomes of these tumors based on overallsurvival greater or less than 1 year from diagnosis. METTL6 is a tRNA methyltransferase that is involved inthe m3c RNA modification (2), whereas METTL10 is a lysine methyltransferase that is involved in theeukaryotic translation factor EF1A1 (3). When patients with PDAC were categorized based on survival, asimilar enzyme, METTL1 (5, 6), was similarly differently expressed, according to a separate dataset (4). Theseresults suggest that METTL1, METTL6, and METTL10 might be used as therapeutic targets in a disease withno known targeted medicines, a median survival of 6 months, and a 5-year survival rate of 3-5 percent (7).
Statistical learning of target and distractor spatial probability shape a common attentional priority computation
Authors: Ferrante Oscar , Chelazzi Leonardo , Santandrea Elisa
Published: June 2021

Converging evidence recently put forward the notion that dedicated neurocognitive mechanisms do exist for the suppression of salient, but irrelevant distractors. Along this line, it is plausible to hypothesize that, in appropriate contexts, experience-dependent forms of attentional learning might selectively induce plastic changes within this dedicated circuitry, thus allowing an independent shaping of priorities at the service of attentional filtering. Conversely, previous work suggested that statistical learning (SL) of both target and distractor spatial probability distributions converge in adjusting only the overall attentional priority of locations: in fact, in the presence of an independent manipulation, either related to the target or to the distractor only, SL induces indirect effects (e.g., changes in filtering efficiency due to an uneven distribution of targets), suggesting that SL-induced plastic changes affect a shared neural substrate. Here we tested whether, when (conflicting) target- and distractor-related manipulations are concurrently applied to the very same locations, dedicated mechanisms might support the selective encoding of spatial priority in relation to the specific attentional operation involved. In three related experiments, human healthy participants discriminated the direction of a target arrow, while ignoring a salient distractor, if present; both target and distractor spatial probability distributions were concurrently manipulated in relation to each single location. Critically, the selection bias produced by the target-related SL was marginally reduced by an adverse distractor contingency, and the suppression bias generated by the distractor-related SL was erased, or even reversed, by an adverse target contingency. Our results suggest that even conflicting target- and distractor-related SL manipulations result in the adjustment of a unique spatial priority computation, likely because the process directly relies on plastic alterations of shared spatial priority map(s).
Assessing the Impact of COVID-19 Pandemic on Vulnerable Populations in Bangladesh
Authors: Kumar Bezon , Kamal Raihana Sayeeda , Parvin Rawnaq Ara , Waresi Noushin Mouli
Published: June 2021

COVID-19 has affected all classes of people over the world in many ways. In major cases, the impact of COVID-19 on vulnerable group of people is overlooked though they are the major part of the society. Thus, this paper aims at investigating the impacts of COVID-19 on vulnerable people in Bangladesh intensively. Using literature review and case studies, this paper finds some interesting findings. The daily income of poor classes of people like day laborers, Rickshaw pullers, transport workers and so on reduced by 64.37 percent during COVID-19 situation. On the other hand, about 3.7 million new poor emerged amid this pandemic. Amid this pandemic, about 50 percent of women-led enterprises are laying off 76-100 percent of their workers while about 2.14 million garment workers were laid off. More effective policies should be taken to tackle the adverse impacts of COVID-19 pandemic on vulnerable populations than what is already taken by the government and NGOs.
Rankings statt Stellenordnungen? Funktionen und Folgen von Leistungsvergleichen in internationalen Organisationen
Authors: Youssef Ramy
Published: June 2021

Der Ausgangspunkt dieses Beitrags liegt in der Vermutung, dass Rankings für Internationale Organisationen die Möglichkeit bieten, eine fehlende Stellenordnung im Verhältnis zu ihren Mitgliedsstaaten zu substituieren. Rankings, so die These, bearbeiten dann Funktionen der Planung, Koordination und Kontrolle von Entscheidungsprämissen in IOs und kompensieren dadurch in bestimmten Hinsichten die Folgen einer fehlenden Stellenordnung.
Abweichung und Konformität – Prolegomena zu einer historischen Wissenssoziologie der Imitation
Authors: Youssef Ramy
Published: June 2021

Imitation is a semantic scheme for the observation of social behaviour. Its function lies in the control of conformity and deviance on the basis of similarities with a given model and thus provides orientation for social expectations. However, not all similarities presuppose imitative contacts but may be the outcome of convergent developments despite different starting conditions. Furthermore, functional equivalents mayserve as substitutes for imitation. For example, persons or artifacts can be exemptedfrom imitating or being imitated if they are considered to have a unique andincomparable quality. The semantics of imitation vary historically and thus providealso information about changes in practices of imitation and their social value.
COVID–19 Exposes the Need for Public Health Preventive Medicine Physicians: A Proposal for A Gazan PHPM Residency Program
Authors: Sabra ZM , Gomez Saylin , Mahayosnand Ponn P
Published: June 2021

Executive SummaryThe COVID-19 pandemic exposes the need for public health preventive medicine (PHPM) physicians in Gaza, Palestine. The lack of public health education in Gaza causes its population, physicians included, to be unaware of the necessity of preventative medicine, especially during this pandemic. We propose that the Palestine Medical Council (the Council) implements the following policy steps: 1. Approve the Gaza Medical Reserve Corps (the Reserves) as creators, trainers, and hosts of Gaza’s PHPM residency program; 2. Certify the PHPM board exams, assist in medical education, and issue the specialty license; and 3. Support the Reserve’s efforts to gain financial sustainability and adhere to health laws and ethics.According to Articles 4 and 5 of the Council’s Objectives and Functions, the Council has the authority to execute these steps. In doing so, PHPM physicians will be able to provide Gazans with primary care and telehealth services currently unavailable and relieve overworked physicians who average 113 daily medical consultations. The Reserves currently serve three of PHPM physicians’ four duties: education and outreach, research and development, and public health policy and advocacy. PHPM physicians will not be able to fulfil its fourth duty of providing health services without the Council’s support. By helping establish the PHPM specialty, the Council will assist in strengthening Gaza’s healthcare infrastructure during this critical time, which will, in turn, aid in the betterment of Gaza's overall health.
Nawawi al-Bantani, Ashhab al-Jawiyyin di Bidang Hadis: Rihlah, Genealogi Intelektual, dan Tradisi Sanad Hadis
Authors: Hafidhuddin Hafidhuddin , Qudsy Saifuddin Zuhri
Published: June 2021

Nawawi al-Bantani as an archipelago scholar through the Tanqih al-Qaul has contributed to the study of hadith in the mid-nineteenth century AD. The intellectual tradition developed by Nawawi al-Bantani became the scientific traditions that developed in Haramayn (Mecca and Medina), and the traditions Islam in the archipelago, especially in Islamic boarding school on an ongoing basis. This study aims to determine the socio-historical intellectual traditions of Nawawi and fiqh al-hadith contained in the Tanqih al-Qaul. Departing from that, the historical research method is used in uncovering the object of research. The results of this study indicate that the Lubab al-Hadith by al-Suyuthi (d. 911) was first recited by Nawawi al-Bantani in the mid-nineteenth century AD, through the syarah compiled by Nawawi there were seven ideas in the context of understanding hadith (fiqh al-hadith), this refuses the notion that the study of the eyes has not been touched, Nawawi al-Bantani has made efforts in this regard. In addition, Nawawi as sayyid ulama’ al-hijaz and musnid, not only compiled hadith books and spread his thoughts in the field of hadith, which at that time was more oriented towards the dialectics of sufism and fiqih. Through Nawawi, the intellectual genealogy traditions called sanad continues to be continuous, especially for students and scholars in the archipelago after that and brings its own style to the tradition of learning hadith in Indonesia.
Organizational Culture Dimensions in the Management of PM Gontor 7 Putera, Southeast Sulawesi
Authors: Syahrul Syahrul , Suryadi Suryadi
Published: June 2021

This article aims to investigate: (1) ideas and ideals of the establishment of PM Gontor; (2) Phases of the grounding of Gontor's PM ideas; 3) Proliferation of PM Gontor as the largest pesantren corporation in Indonesia; 4) Elements of Gontor's organizational culture. Data was collected through interviews, observations, and documentation studies. Data analysis was carried out through four stages, namely: domain analysis, taxonomic analysis, compound analysis, and analysis of cultural themes. The results showed: (1) The existence of PM Gontor started with Pesantren Tegalsari ideas about the responsibility of advancing the Islamic Ummah and seeking the pleasure of Allah SWT; (2) The earthing phases of PM Gontor's ideas stretched during the founding of Old Gontor, the planting of shared values in the New Gontor era, instilling shared values through tiered education (3) The Gontor PM Proliferation is an effort to spread Gontor energy throughout Indonesia; (4) The elements of organizational culture in PM Gontor include the ideas/ideals of Tegalsari, educational strategies, shared values in the five souls, and the application of the five-term as a producer of the PM Gontor artifacts. The implication of this research is to continuously improve educational institutions by revitalizing the main dimensions of organizational culture.
Penolakan Peran Dokter Sebagai Eksekutor Sanksi Hukum Kebiri di Indonesia: Perspektif Filsafat Hukum Islam
Authors: Harahap Abdul Aziz , Islamy Athoillah
Published: June 2021

Behind the pro-contra polemic of imposing castration legal sanctions for criminals of pedophilia in Indonesia, doctors have a dilemma as a profession that is considered to have medical competence and is worthy of being executors. It is due to the principle of maintaining the safety of human souls and the prohibition of taking action that endangers the lives of others in the code of ethics for the medical profession. The research seeks to present the perspective of Islamic legal philosophy in analyzing the arguments in the Indonesian Doctors Association (IDI) rejection as the executor of the punishment for castration. This research is qualitative in the form of a literature review. This type of legal research is included in the category of philosophical normative Islamic law research using Islamic law principles (qawaid fiqhiyah). This research concludes that the principle of not endangering the safety of others in the medical profession is parallel to the rules of Islamic law (fiqh) which reads al-ḍararu yuzālu (fade must be eliminated). However, the provisions of the fiqh rule are not absolute. It means that under certain conditions, the act of harming someone is allowed in order to create public benefit (al-maslahat al-ammah). Therefore, a doctor who serves as executor in applying the caste penalty for pedophile offenders does not contradict the philosophy of Islamic law.
Relasi Kekerabatan Patronase Masyarakat Muna
Authors: Zainal Asliah , Zainal Muhammad Asrianto , Rafiah Waode Ainul , Wa Kina Wa Kina
Published: June 2021

This study is addressed to two things: the relationship of kinship and patronage, which take place in social aspect (education and economy) and culture (life cycle ceremony), and the relation of patronage kinship system, which implies on cohesion social community of Muna. This study showed that the relation of the Muna family was tied socially and culturally by two vertices, descent/affinity relation and patronage relation or patronage kinship system and in local term called intaidi bhasitie (we are family). The patronage kinship in Muna family works in almost every aspect of community life, both in social; educational, economic, even political; and cultural (life cycle ceremony). By using Anthropological family, this study argues that the kinship systems wrapped by patronage or boosted patronage by kinship relationships are neither firm nor sustainable. It may be safe in education, economy, and cultural aspects but may be weakened in political preference. Even though a relative still tied up in a family's node but his indifference will be called "family but not". This social relationship will threaten the bond of kinship that eventually fragile and unravel, and the social relation seems to be a pseudo kingship. This research implies that the social relations of patronage kinship will threaten kinship ties which are eventually fragile and unravel, resulting in pseudo kingship if the conditions for a patron-client as Scott's theory are not fulfilled, and eventually become a transactional relationship bond. This research is expected to provide an understanding that kinship ties or patronage relations are traditionally socio-cultural capital that is increasingly threatened by the demands of economic and political interests in modern transactional relationships.
Letter to Editor: Zoonotic Perspective of 2019 Novel Coronavirus Disease (COVID-19)
Authors:   1Lab of Molecular Immunology, School of Life Sciences, Fudan University, Shanghai, China, Habib Arslan
Published: June 2021

Recently Biscayart et al. stated that coronaviruses cause deleterious diseases in both humans and animals. In the previous three decades China affected with different kinds of viral outbreaks in which include avian influenza disease in 1997, severe acute respiratory syndrome (SARS) in 2003 and severe fever with thrombocytopenia syndrome (SFTS) in 2010. The current outbreak of novel coronavirus disease (2019-nCoV) is much similar in case of symptoms with SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV).
Genetic Basis and Novel Treatment Strategies in Parkinson's Disease – A Review
Authors:   Department of Pharmacology, Banaras Hindu University, Varanasi, U.P. India, Gangadhar Nagare Santosh
Published: June 2021

Parkinson's disease (PD) is the 2nd most common progressive neurodegenerative disorder after Alzheimer's disease. Approximately 60000 are diagnosed with Parkinson's disease each year and more than 10 million people are living with PD. PD is a neurodegenerative disorder in addition to the causes of PD are so many, it's not caused by a single pathophysiologic disturbance. So many drugs are available to treat PD but all are only for symptomatic relief no one drug is a disease-modifying agent. Although so many targets are available for targeting the Synuclein alpha, mitochondrial oxidative stress, autophagy, targeting glial cell inflammation, targeting metal ion homeostasis. But till now no one drug is successful in targeting these targets. In this review, we have summarized the genetic basis and novel targets available for the disease-modifying strategy for PD.
A Review on Post COVID-19 Effects
Authors:   Department of Pharmacology, Dattakala College of Pharmacy, Savitribai Phule Pune University, Taldaund, Pune, Maharashtra, India, Lonkar Bhakti Kundlik
Published: June 2021

The whole world is under threat, due to the pandemic situation of COVID-19. According to the data, more than 30 million people were infected and over 1 million died all over the world. The clinical data states that, people recovered from COVID develop long-term effects on their body. More than 4 million people in US, UK and Sweden had symptoms after recovery from COVID, which was termed as post-acute COVID-19. The serious effects were observed like pulmonary dysfunction, myocardial inflammation and impaired mental health. There were serious heart and kidney related issues, which were observed. However, the people are in great danger, those who are suffering from post COVID effects.
High Prevalence of Mitochondrial tRNA A3243G Mutation in Invasive Breast Cancer
Authors: Alhomidi Mohammed A. , Hasan Qurratullain
Published: June 2021

Background & Aim: Mitochondria play vital roles in various cellular activities, such as energy production, maintaining the redox balance of the cell, the regulation of cellular proliferation and differentiation, and programmed cell death. Mitochondrial tRNA mutations are associated with many pathological conditions and numerous diseases have been associated with them. Therefore, the objectives of this study were to evaluate the presence and the frequency of mutations in the selected tRNAs in breast cancer patients and to correlate these mutations with the clinicopathological characters. Materials & Methods: The is a cross sectional study, where seventy seven breast tumors and adjacent non-tumorous (normal) tissue samples were analyzed by PCR- RFLP, and direct DNA sequencing. In this study three mt-tRNAs wre selected, two of them are the most important disease associated mt-tRNAs i.e tRNALue (UUR), tRNALys and one of the least pathogenic associated tRNA which is tRNAarg. Statistical analysis was used to determine the relationship between the detected mutations and the clinicopathologhical characters. Results: The tRNAleu (UUR) A3243G mutation occurring at the highly conserved location was detected in 4 samples (5.2%) of both breast cancer and adjacent non-tumorous tissue except one detected only in tumor tissue. Another A8343G mutation was detected in tRNAlys. There was no significant association between these mutations and clinicopathological parameters (P. value > 0.05). Conclusion: The detection of high frequent A3243G mutations in patients with invasive breast cancer suggests role of this mutation in the carcinogenesis. This mutation affects complex I, reduces translation of its core subunits, which can contribute to the impairment of oxidative phosphorylation and increase ROS production, leading to cancer progression.
Tissue Zinc Concentration in Prostate Cancer: Relationship with Prostate Specific Antigen and Gleason Score in a Cohort of Nigerian Men
Authors: Igbokwe Martin , Salako Ayo , Badmus Tajudeen , Obiajunwa Eusebius , Olasehinde Olalekan , Igbokwe Chiamaka , David Rotimi
Published: June 2021

Introduction: Prostate cancer (PCa) is the commonest maliganacy among men of African descent. The possible role of trace elements like Zinc in its aetiogenesis and disease severity remains controversial. This paper aims to identify the relationship between tissue zinc concentration and the occurrence of prostate cancer. And to identify the relationship between the tissue zinc concentration and the disease severity (using the prostate specific antigen (PSA) and Gleason scores (GS)).Methodology: A cross-sectional study of 41 consecutive consenting men with histologically confirmed PCa and 41 age-matched controls. Toe-nail clippings were obtained from both groups and assayed for zinc using the Particle induced X-ray emission (PIXE) technique. Zinc concentrations were compared between cases and controls. A correlation analysis was performed to determine relationship between Zinc concentration and disease severity (PSA and GS). Results: Forty one men each were recruited in the Prostate cancer and control groups for this study. PCa group had a mean age of 72.83 ± 7.06 years while the control group was 70.73 ±6.40 years. There was statistically significant higher toe-nail Zn concentration among Prostate cancer patients than controls (P= 0.028, t=2.28, df=40). The mean PSA values among the Prostate cancer group was 46.10 ± 40.62ng/ml and mode GS was 8.There was neither a correlation between toe-nail Zn concentration and serum PSA levels (p=0.386) nor with the GS. Conclusion: This study found a statistically significant higher toe-nail Zn concentration among men with PCa compared with age-matched controls. There was however no correlation between toe-nail Zn concentration and the serum prostate specific antigen or Gleason score.
LAJU KEMUNDURAN MUTU GONGGONG (Strombus sp.) REBUS PADA PENYIMPANAN SUHU CHILLING DAN RUANG DENGAN MUTU SENSORI
Authors: Syafitri Vika Annur , Rezeki Zubaidah Anjar , Apriandi Azwin
Published: June 2021

This research was conducted to observe the rate of deterioration in the quality of

boiled snails (Strombus sp.). Organoleptic is a method of sensory freshness determination. The

speed at which a snail decomposed was primarily influenced by the temperature. This study

aims to determine the best quality of barking snails stored at chilling and rooming temperatures.

Samples of barking snails were taken from Tanjung Unggat water. This research method

includes measuring the morphometric, yield, and organoleptic of the barking snail (Strombus

sp.). The results showed that the use of chilling temperature could extend the shelf life of boiled

barking snails, as evidenced by the high value of the organoleptic parameters compared to

barking snails at room temperature storage, based on the organoleptic parameters of frozen

clam meat based on SNI 3460.1-2009.
PERUBAHAN KOMPOSISI KIMIA KIJING LOKAL (Pilsbryoconcha exilis) SEGAR DAN KUKUS
Authors: Nurjanah Nurjanah , Jacoeb Agoes M. , Hidayat Taufik
Published: June 2021

Local mussel is a type of shellfish which is rich in minerals, fatty acids and essential

amino acids and has a low cholesterol content. The local gravestone is currently only used as

food by the local community which is processed by steaming. This study aims to determine the

chemistry of the local gravestone. The research method used was morphometric, proximate

analysis, amino acids using HPLC, fatty acids using GC, and minerals using AAS. The

proximate results showed that the air and fat content decreased, while the ash, protein, and

carbohydrate content increased due to the steaming process. Saturated fatty acids in local

mussels tend to rise after steaming, except for palmitic which has decreased, while unsaturated

fatty acids have decreased after steaming. Protein The salt-soluble content of local mussel is

higher in air-soluble protein. The highest amino acid content is glutamic acid. The highest macro

mineral content in local mussel meat is calcium 5,808.85 ppm, and the highest is sodium at

51.46 ppm, while the highest micro mineral is iron at 445.06 ppm, and the best is copper at 0.16

ppm . Generally, the chemical composition of local mussels on average decreased after the

steaming process.
LAJU KEMUNDURAN MUTU GONGGONG (Strombus sp.) SEGAR PADA PENYIMPANAN SUHU CHILLING DAN RUANG DENGAN MUTU SENSORI
Authors: Shellim Indriyani , Aisyah Aisyah , Apriandi Azwin
Published: June 2021

The purpose of this research was to analyzed the rate of the quality of fresh gonggong snail (Strombus sp.) stored at chilling and space temperature within 24 hours. The research method used consisted of morphometric test, yield test and sensory test with characteristics of appearance, texture and smell of gonggong snails. The results of the study based on observations of deterioration in quality of fresh gonggong snails (Strombus sp.) can be seen from the morphometric observations of gonggong, namely obtaining an average total weight of 23.36 ggonggong, 5.98 g length, and 3.6 g width. Based on the results, the yield of shell research was the largest portion at 60.77%, the meat yield was 21.25%, while offal was the smallest part, which was 15.83%. Observations on the sensory test at chilling temperature using a temperature of 5ºC were carried out for 4 hours 1 time observation with the characteristics of appearance, texture and smell making the sample not too fast to experience the process of decay and change in the sample. While the sensory test observations at room temperature are carried out for 24 hours. 1 time the observation of the quality deterioration process occurs very quickly because storage at room temperature can accelerate the deterioration of quality due to bacterial overhaul occurs very quickly.
KARAKTERISITIK ORGANOLEPTIK BAKSO IKAN GABUS DENGAN PENAMBAHAN PATI JAGUNG DAN TEPUNG TAPIOKA
Authors: Mardesci Hermiza , Imaryana Imaryana
Published: June 2021

Snakehead fish is one type of fish that is widely found in Indragiri Hilir which is known as â€œharuanâ€ fish. This fish has high economic value if it is processed into processed food products, such as meatballs. Processing of snakehead fish into meatballs can be done by adding other ingredients, such as tapioca flour, sago flour, corn starch, and other flours. This study aims to determine the effect of adding corn starch and tapioca flour to the organoleptic characteristics of the resulting snakehead fish meatballs. The results showed that the snakehead balls most favored by the panelists were snakehead fish balls with the addition of 7.5% corn starch and 2.5% tapioca flour by weight of the ingredients.
EDIBLE FILM DARI KARAGENAN DAN MINYAK CENGKEH SEBAGAI ANTIMIKROBA PADA IKAN SEGAR
Authors: Jaja Ali , Putri R. Marwita Sari , Jumsurizal Jumsurizal
Published: June 2021

Edible film is a type of packagingthat is both effective and safe. Edible film maked using natural ingredients such as carrageenan. Clove oil addetional to enhance its antimicrobial function. This study puposed to determine the effect of using carrageenan and clove oil concentrations in the organoleptic and ALT test. The design used was used was CRD with test parameter namely thikness tset, elongation, tensile strenght, organoleptic quality obcervation and ALT. Thikness test result 0.02-0.13 mm, elongation 1.027-1.117%, tensile strength 0.088-0.095 MPa, the best organoleptic is A2 on parameter (eyes, smell and texture), ALT A1 value (1.4x103 koloni/g) amd A2 (9.4x102 koloni/g). the reduction of carrageenan and additional of clove oil resulted in increased thikness and tensile strenht, while decreasing elongation. Based on the organoleptic test, the best the best treatment was edible film A2. ALT A1 and A2 test result do not exceed the threshold.
TEKNIK IMOTILISASI IKAN KERAPU CANTANG (Epinephelus sp.) MENGGUNAKAN EKSTRAK DAUN KECUBUNG (Datura metel L.)
Authors: Akbar Rusdi , Jumsurizal Jumsurizal , Putri R. Marwita Sari
Published: June 2021

The immotilization technique of cantang grouper (Epinephelus sp.) Using Datura metel L. leaf extract. The purpose of this study was to find the best concentration at onset time of Datura metel L. leaves as anesthetic agent for grouper (Epinephelus sp.) And its survival rate. The results of the study, using extracts of natural anesthetic ingredients of amethyst leaves with concentrations of 20%, 25%, and 30% had different effects (P <0.05) on the onset time and recovery of grouper fish. In this study, it provides a life passing rate of 100% at concentrate 20%, and 25%, while concentrate 30% has a 66.67% survival rate. The best concentration in this study was concentrate 30%, with an onset time of 32.07 minutes with a recovery time of 9.07 minutes. This study used a non-factorial completely randomized design (CRD).
EFEK PENAMBAHAN EKSTRAK RUMPUT LAUT Eucheuma Cottonii PADA PEMBUATAN ES BATU TERHADAP KEMUNDURAN MUTU KERANG LOKAN (Geloina erosa) DAN KERANG DARAH (Anadara granosa)
Authors: Agusnia Habsah , Fatmawati Kiki , Suhandana Made
Published: June 2021

Phylum molusca is a group of animals that are soft-bodied and have no spine (invertebrates). One of the phylum molusca is a class of Bivalvia that is generally in the form of lateral symmetry, a type of bivalvia that is often found in the water of Riau Islands is Lokan shells (Geloina erosa) and Darah shells (Anadara granosa) that live in tidal areas. The purpose of this study is to find out if the addition of water ice cubes resulting from the extraction of seaweed Echeuma Cottonii is effective for lokan shells and blood shells. Based on the results of the study obtained for the meat rendment of each shell is 85.39% in lokan shells and 84.27% in darah shells. Organoleptic results showed a more effective treatment of shellfish treatment with the addition of regular ice cubes, Water Holding Capacity (WHC) for the treatment of water ice cube extract binding or absorbing more water than regular ice cube treatment. The second pH of shellfish from three treatments had a value below 7, the lowest acidic pH obtained treatment with seaweed ice cubes.
STUDI KADAR LOGAM BERAT TIMBAL (Pb) PADA KERANG HIJAU (Perna viridis) DI WILAYAH NGEMBOH, GRESIK DAN PPDI PELABUHAN PERIKANAN NUSANTARA BRONDONG, LAMONGAN, JAWATIMUR
Authors: Rahardja Boedi Setya
Published: June 2021

Marine pollution occurs due to the entry of industrial waste containing chemicals into the aquatic will cause changes to its ecological conditions. Pollutants contained in the waste are in the form of sediment nutrients, pesticides, pathogenic organisms, waste and heavy metals. The purpose of this study was to determine the content of heavy metal Pb in green mussels (Perna viridis), water, and sediments in the Ngemboh, Gresik area and in the waters of the Nusantara Brondong Fishery Port, Lamongan, East Java. The research is observational research with analysis data using linear regression, simple correlation (pearson) and ANOVA. The data collection was carried out by purposive random sampling. The heavy metal content of lead (Pb) in green mussels in Ngemboh waters, Gresik has a heavy metal content of lead (Pb) of 0.871 ppm, 0.199 ppm, 0.161 ppm. The cause of the high content of heavy metal lead (Pb) at station 1 is because it is close to the mouth of the Ngemboh river, where both organic and inorganic waste originate from local residents. Meanwhile, the content of the heavy metal lead (Pb) in green mussels in the waters of the Indonesian fishing port in the archipelago of Brondong, Lamongan, has various values. The values of heavy metal lead (Pb) at both stations were 0.37 ppm and 0.053 ppm. The content of heavy metal lead (Pb) in green mussels has not exceeded the threshold specified in SNI 01-7387-2009, which means that green mussels are still fit for consumption.
SOCIAL SYSTEMS, MODELS, TRANSFORMATIONS: ANALYSIS OF THEORETICAL APPROACHES
Authors:   Siberian federal university, Sertakova Ekaterina
Published: June 2021

This article aims to consider key concepts and models from the theory of social systems that can be used as a theoretical basis for conducting cultural and anthropological research. Based on the analysis of a number of authoritative sources, attention was focused on the activity approach, which takes into account the role of the elements of the system (a person, specific communities and groups) in its functioning and change. In addition, the issue of the dynamics of social systems of different types (classical, nonclassical and postclassical) was analyzed, which allows you to pay attention to the transformations taking place in a modern multicultural urban society or the traditional society of an ethnic village, to identify their regularity, to fix the direction. Also in this work, models of social transformations in culture are considered - Westernization, destabilization, assimilative-religious, and in our opinion the most effective is the modernization-traditionalist model, the elements of which contribute to the preservation of traditional value dominants and allow you to develop a program for the sustainable development of a state, region or small territory in the global world.
CONCEPTS "NATION", "NATIONALISM", "NATIONAL STATE" AS ELEMENTS OF A MODERN PROJECT
Authors:   Siberian federal university, Zamaraeva Julia
Published: June 2021

The article is devoted to an analytical review of scientific research literature on the problems of defining the concepts of "nation", "nationalism", "nation state" as basic for understanding the essence of the project of modernity in the XXI century. The aim is to fix the content of the terminological apparatus on the problems of the national and to align the research priorities in accordance with the modern trends of the globalizing world. The study identifies the relevance of the topic research, reveals the technologies for constructing the concept of "nation" in foreign scientific research of the 19th - 20th centuries, analyzes the concepts of "nationalism" and "nation state" in the context of a modern project.
THEORETICAL, APPLIED AND SYNTHETIC METHODS OF STUDYING CULTURE AS A SOCIO-ANTHROPOLOGICAL SYSTEM
Authors:   Siberian federal university, Sitnikova Aleksandra
Published: June 2021

The article provides an overview and offers a classification of modern methodological approaches in the field of cultural studies. The article helps to choose an appropriate methodological strategy for conducting cultural research. Cultural studies methods are classified into three types: theoretical, applied and synthetic. The article discusses the specificity, advantages and disadvantages of such methods as field research, an interdisciplinary approach involving sociological analysis, archaeological analysis, art analysis, psychological experiment for cultural studies, and also considers the methodology of structuralism, functionalism, hermeneutics and linguocultural studies.
ВЗАИМОДЕЙСТВИЕ АДРЕСАТА ХУДОЖЕСТВЕННОЙ КРИТИКИ И ПРОИЗВЕДЕНИЯ ИЗОБРАЗИТЕЛЬНОГО ИСКУССТВА
Authors:   Siberian federal university, Reznikova Ksenia , Smolina Maya ,   Siberian federal university
Published: June 2021

The object of this scientific research is art criticism, the subject is the interaction of the addressee of art criticism and a work of fine art. The aim is to study the relationship between the addressee of art criticism and a work of fine art. The conceptual analysis of the concept of "art criticism" is given, the features and structure of the text of art criticism are considered. The conceptual basis for the study was the key provisions of the theory of reflection by G.V.F. Hegel, the basic principles of the synthetic theory of the ideal D.V. Pivovarov and the concept of ideal formation, the main provisions of the theory of fine art by V.I. Zhukovsky and N.P. Koptseva. A peculiar result of scientific research is the fixation of the characteristics of various addressees of the text of art criticism ("viewer" and "artist") and the specifics of their relationship with a work of fine art through the study of the text of art criticism
THE ESSENCE OF THE CONCEPT OF "GROUP PORTRAIT" AND THE TYPOLOGY OF THE GENRE OF GROUP PORTRAIT
Authors:   Siberian federal university, Sorokina Yulia , Shukovski Vladimir ,   Siberian federal university
Published: June 2021

This article is devoted to identifying the uniqueness of the works of the genre "group portrait" by etymological research of the concept "group portrait", identifying the typology of this genre, exploring the traditional possibilities of its systematization in order to comprehensively consider the essence of the group portrait in the research tradition. The aim of the study is to deepen the understanding of the genre of group portrait and its specific features. The methodological bases of the research are the basic categories of the theory of reflection of G. V. F. Hegel, the basic principles of the synthetic concept of the ideal by D. V. Pivovarov, the theory of fine art by V. I. Zhukovsky, N. P. Koptseva, as well as general scientific empirical and theoretical research methods.
TO STUDY THE SOCIO-DEMOGRAPHIC PROFILE PATIENTS UNDERGOING LICHTENSTEIN TENSION FREE INGUINAL HERNIOPLASTY FOR FOR INGUINAL HERNIA
Authors: Negi Prteet , Thakur Priyanka , Bharti Ramesh , Verma Amar , Sharma Rajesh , Sharma Abhinav
Published: June 2021

Background: All the hernias, 75% occurs in groin and inguinal hernia is the most common form of all. Acquired hernia can be direct, indirect or combination of both. In adult males 65% of inguinal hernias are indirect and 55% of them are right side.

Methods: This prospective study was conducted in the Department of Surgery, Dr. Rajendra Prasad Government Medical College Kangra at Tanda from May 2018 to December 2019after being approved by institutional protocol review committe and ethics committee.50 patients were included in the study.

Results: In our study, the patients age ranged from 18 years to 87 years with a mean age of 50.26±15.76 years. 22 (44%) patients had inguinal hernia on right side

Conclusion: We concluded that mostly patients were more than 50 yrs age group and right side.

Keywords: Age, Site, Hernia
Optimize the Time and Network on the Distribution of Tempe Industry by Using the Approach of the Assignment and Networking
Authors: Agnia Gina , Herwanto Dene , Hoerunisa Ica , Nugraha Billy , Sari Rianita Puspa
Published: June 2021

The problems that occur in the soybean tempe home industry are the competition in the market sector and unstable prices. The purpose of this study is to determine the assignment of employees in performing their works and to distribute them to each destination with the shortest distance. The research method used is assignment, networking using the assistance of the operations management software program - quantitative methods (POM-QM) for windows. The data used are the primary data conducted in a preliminary study. In addition, data collection techniques are carried out in several ways, namely interviews, observation and schedule recording. The finding provides optimal results for all four employees based on suitable jobs. Each employee is employee 1 with a type of laundering taking 17 minutes. Employees 2 with a kneading type of work taking 35 minutes. Eemployees 3 with wrapping job type taking 10 minutes. Meanwhile, eemployees 4 is breawing taking 15 minutes. In addition, the distribution of tempe to the destination point with the shortest route produces a distance of 76 km.