bluuebunny/crossref_metadata_2025 huggingface dataset:
A Method for Generating a Well-Distributed Pareto Set in Multiple Objective Mixed Integer Linear Programs Based on the Decision Maker’s Initial Aspiration Level
Authors: Razavyan S.
Published: July 2016

This paper attempt to generate a representative subset of the Pareto optimal set for multiple objective mixed integer linear programming problem using the weighted L1 norm distance. The procedure presented in this paper is somewhat similar to the one used in the ideal-point methods and its aim is to generate at each iteration the closest-points to the ideal vector corresponding to the decision maker’s initial aspiration level for a new tradeoff parameter. Unlike most of the known algorithms for generating a discrete representation of the Pareto optimal set, the procedure generates at each iteration a nondominated point by solving only one mixed integer linear programming problem. The obtained solution minimizes the weighted L1 norm distance to the ideal vector with respect to the distance between the ideal vector and previously found vectors. More generally, this approach is able to generate all Pareto optimal solutions, where all of the decision variables are restricted to be integer. In order to explain the presented details, several illustrative examples are provided.
Non-Abelian monopoles as the origin of dark matter
Authors: Falomir H. , Gamboa J. , Méndez F.
Published: July 2016

We suggest that dark matter may be partially constituted by a dilute ’t Hooft–Polyakov monopoles gas. We reach this conclusion by using the Georgi–Glashow model coupled to a dual kinetic mixing term [Formula: see text] where [Formula: see text] is the electromagnetic field and [Formula: see text] the ’t Hooft tensor. We show that these monopoles carry both (Maxwell) electric and (Georgi–Glashow) magnetic charges and the electric charge quantization condition is modified in terms of a dimensionless real parameter. This parameter could be determined from milli-charged particle experiments.
Lower bounds for Pólya’s problem on permanent
Authors: Budrevich Mikhail , Dolinar Gregor , Guterman Alexander , Kuzma Bojan
Published: July 2016

We found the lower bounds on the number of ones in fully indecomposable [Formula: see text] matrices such that their permanents are equal to the determinants of matrices obtained by a suitable change of signs in the entries. We consider separately general case and the case of symmetric matrices with vanishing diagonals.
The MCM-approximation of the trivial module over a category algebra
Authors: Wang Ren
Published: July 2016

For a finite free EI category, we construct an explicit module over its category algebra. If in addition the category is projective over the ground field, the constructed module is a maximal Cohen–Macaulay approximation of the trivial module and is the tensor identity of the stable category of Gorenstein-projective modules over the category algebra. We give conditions on when the trivial module is Gorenstein-projective.
Disturbance Rejection for Fractional-Order Time-Delay Systems
Authors: Jiang Hai-Peng , Liu Yong-Qiang
Published: July 2016

This paper presents an equivalent-input-disturbance (EID-) based disturbance rejection method for fractional-order time-delay systems. First, a modified state observer is applied to reconstruct the state of the fractional-order time-delay plant. Then, a disturbance estimator is designed to actively compensate for the disturbances. Under such a construction of the system, by constructing a novel monochromatic Lyapunov function and using direct Lyapunov approach, the stability analysis and controller design algorithm are derived in terms of linear matrix inequality (LMI) technique. Finally, simulation results demonstrate the validity of the proposed method.
Calculation of Constrained Stress in Expansive Mortar with a Composite Creep Model
Authors: Choi Hyeonggil , Cho Bongsuk
Published: July 2016

The creep phenomenon of hardening cement paste mixed with an expansive additive was modeled by considering the creep performance of hydration products of cement and expansive additive. A new composite model that is appropriate for particle conditions is proposed by considering the balance of the hydration products of cement and expansive additive and the stress redistribution phenomenon of hydration products newly generated by the progress of hydration. The creep of mortar and concrete mixed with the expansive additive was evaluated using a composite model of the paste and aggregate. Under the assumption that the modeled creep deformation is proportional to the stress and the gel volume of the hydration products, which allows the law of superposition to be applied, the distribution stress was predicted by applying the step-by-step method at each time increment. By predicting the maximum tensile stress applied to an inner steel ring through a creep analysis based on the measured deformation of the inner steel ring, it is possible to predict the stress progression with age to some degree.
A Game-Theoretical Approach for Spectrum Efficiency Improvement in Cloud-RAN
Authors: Zhou Zhuofu , Peng Jun , Zhang Xiaoyong , Liu Kaiyang , Jiang Fu
Published: July 2016

As tremendous mobile devices access to the Internet in the future, the cells which can provide high data rate and more capacity are expected to be deployed. Specifically, in the next generation of mobile communication 5G, cloud computing is supposed to be applied to radio access network. In cloud radio access network (Cloud-RAN), the traditional base station is divided into two parts, that is, remote radio heads (RRHs) and base band units (BBUs). RRHs are geographically distributed and densely deployed, so as to achieve high data rate and low latency. However, the ultradense deployment inevitably deteriorates spectrum efficiency due to the severer intercell interference among RRHs. In this paper, the downlink spectrum efficiency can be improved through the cooperative transmission based on forming the coalitions of RRHs. We formulate the problem as a coalition formation game in partition form. In the process of coalition formation, each RRH can join or leave one coalition to maximize its own individual utility while taking into account the coalition utility at the same time. Moreover, the convergence and stability of the resulting coalition structure are studied. The numeric simulation result demonstrates that the proposed approach based on coalition formation game is superior to the noncooperative method in terms of the aggregate coalition utility.
Solution of Deformed Einstein Equations and Quantum Black Holes
Authors: Dil Emre , Kolay Erdinç
Published: July 2016

Recently, one- and two-parameter deformed Einstein equations have been studied for extremal quantum black holes which have been proposed to obey deformed statistics by Strominger. In this study, we give a deeper insight into the deformed Einstein equations and consider the solutions of these equations for the extremal quantum black holes. We then represent the implications of the solutions, such that the deformation parameters lead the charged black holes to have a smaller mass than the usual Reissner-Nordström black holes. This reduction in mass of a usual black hole can be considered as a transition from classical to quantum black hole regime.
A Rosenzweig-MacArthur (1963) Criterion for the Chemostat
Authors: Lindström Torsten , Cheng Yuanji
Published: July 2016

The Rosenzweig-MacArthur (1963) criterion is a graphical criterion that has been widely used for elucidating the local stability properties of the Gause (1934) type predator-prey systems. It has not been stated whether a similar criterion holds for models with explicit resource dynamics (Kooi et al. (1998)), like the chemostat model. In this paper we use the implicit function theorem and implicit derivatives for proving that a similar graphical criterion holds under chemostat conditions, too.
Minimizing Total Earliness and Tardiness for Common Due Date Single-Machine Scheduling with an Unavailability Interval
Authors: Low Chinyao , Li Rong-Kwei , Wu Guan-He
Published: July 2016

This paper addresses the problem of schedulingnindependent jobs on a single machine with a fixed unavailability interval, where the aim is to minimize the total earliness and tardiness (TET) about a common due date. Two exact methods are proposed for solving the problem: mixed integer linear programming formulations and a dynamic programming based method. These methods are coded and tested intensively on a large data set and the results are analytically compared. Computational experiments show that the dynamic programming method is efficient in obtaining the optimal solutions and no problems due to memory requirement.
An Improved Fuzzy Based Missing Value Estimation in DNA Microarray Validated by Gene Ranking
Authors: Saha Sujay , Ghosh Anupam , Seal Dibyendu Bikash , Dey Kashi Nath
Published: July 2016

Most of the gene expression data analysis algorithms require the entire gene expression matrix without any missing values. Hence, it is necessary to devise methods which would impute missing data values accurately. There exist a number of imputation algorithms to estimate those missing values. This work starts with a microarray dataset containing multiple missing values. We first apply the modified version of the fuzzy theory based existing method LRFDVImpute to impute multiple missing values of time series gene expression data and then validate the result of imputation by genetic algorithm (GA) based gene ranking methodology along with some regular statistical validation techniques, like RMSE method. Gene ranking, as far as our knowledge, has not been used yet to validate the result of missing value estimation. Firstly, the proposed method has been tested on the very popular Spellman dataset and results show that error margins have been drastically reduced compared to some previous works, which indirectly validates the statistical significance of the proposed method. Then it has been applied on four other 2-class benchmark datasets, like Colorectal Cancer tumours dataset (GDS4382), Breast Cancer dataset (GSE349-350), Prostate Cancer dataset, and DLBCL-FL (Leukaemia) for both missing value estimation and ranking the genes, and the results show that the proposed method can reach 100% classification accuracy with very few dominant genes, which indirectly validates the biological significance of the proposed method.
Eradication and Current Status of Poliomyelitis in Pakistan: Ground Realities
Authors: Ghafoor Shazia , Sheikh Nadeem
Published: July 2016

Pakistan is among the last three countries along with Afghanistan and Nigeria, where polio virus is still endemic. More or less, with some fluctuations, numbers of reported cases in the past few years have shown a rising trend. Year 2014 pushed the country into the deep sea of difficulties, as number of cases rose to red alert level of 328. Security situation has adversely affected the whole immunization coverage campaign. In a country where 40 polio vaccinators have been killed since 2012, such a big number of cases is not a surprising outcome. Worse perception of parents about polio vaccine as in Karachi and FATA, the high risk zones, makes 100% coverage a dream. Minor and perhaps delayed payments to polio workers make them frustrated, resulting in decline of trained manpower for vaccination. Strong implementation of policies is required and those found guilty of attack on polio workers need to be punished. Targeted community awareness programme, strong surveillance network, and involvement of influential religious entities can help to root out polio disease from country. Present review is aimed at analyzing all barriers on the road to success in eradication of polio from Pakistan.
Examining Factor Structure of the Chinese Version of the PIRLS 2011 Home Questionnaire
Authors: Cheung Wai Ming , Lam Joseph W. I. , Au Doreen W. H. , Tsang Hector W. H. , Chan Stephanie W. Y.
Published: July 2016

The home questionnaire of the Progress in International Reading Literacy Study (PIRLS-HQ 2011) was designed to gather information from parents or primary caregivers of fourth-grade pupils on their reading literacy development related to aspects of pupils’ home lives across countries/districts. The questionnaire was translated into different languages for international comparison and research purposes. This study aims to assess the psychometric properties of the Chinese version of the PIRLS 2011 home questionnaire (PIRLS-HQCV 2011) and identify the underlying factor structure using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) among Chinese fourth-grade pupils in Hong Kong. A 7-factor structure model has been identified by EFA and confirmed to resemble much to the original PIRLS structure by CFA. Additional conceptually important domains have been identified which add further insights into the inconclusive results in the literature regarding the relationship between home factors and reading achievement. Implications for further studies are discussed.
Thermal Stresses Analysis and Optimized TTP Processes to Achieved CNT-Based Diaphragm for Thin Panel Speakers
Authors: Lai Feng-Min , Peng Chang-Yi
Published: July 2016

Industrial companies popularly used the powder coating, classing, and thermal transfer printing (TTP) technique to avoid oxidation on the metallic surface and stiffened speaker diaphragm. This study developed a TTP technique to fabricate a carbon nanotubes (CNTs) stiffened speaker diaphragm for thin panel speaker. The self-developed TTP stiffening technique did not require a high curing temperature that decreased the mechanical property of CNTs. In addition to increasing the stiffness of diaphragm substrate, this technique alleviated the middle and high frequency attenuation associated with the smoothing sound pressure curve of thin panel speaker. The advantage of TTP technique is less harmful to the ecology, but it causes thermal residual stresses and some unstable connections between printed plates. Thus, this study used the numerical analysis software (ANSYS) to analyze the stress and thermal of work piece which have not delaminated problems in transfer interface. The Taguchi quality engineering method was applied to identify the optimal manufacturing parameters. Finally, the optimal manufacturing parameters were employed to fabricate a CNT-based diaphragm, which was then assembled onto a speaker. The result indicated that the CNT-based diaphragm improved the sound pressure curve smoothness of the speaker, which produced a minimum high frequency dip difference (ΔdB) value.
Pauci-Immune Crescentic Glomerulonephritis in Connective Tissue Disease
Authors: Yeturi Supraja , Cronin Mary , Adam Robin , Lorna Campbell , Rosenthal Ann K.
Published: July 2016

Pauci-immune crescentic glomerulonephritis is commonly seen in ANCA-associated vasculitis but it is rarely seen during the course of other connective tissue diseases like lupus or Sjogren’s syndrome or MCTD. We report 3 cases of pauci-immune crescentic glomerulonephritis in patients with connective tissue disease other than vasculitis. We reviewed literature and made summary of previously reported cases of this rare entity. Clinical and laboratory features of these patients varied widely, but most of patients have met criteria for lupus. In this small population of patients there is no correlation with ANCAs. Most of the patients were treated with aggressive immunosuppression and did well if they were treated early in the course of their disease. One of our patients required renal transplant, but she presented late in the course of her disease, as evidenced by chronicity on her renal biopsy. Whether these patients are overlap of vasculitis and other connective tissue diseases or to be considered as a separate entity is yet to be described. Clinicians must be aware of these presentations because initial presentation can be severe.
Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone Status
Authors: Shabanzadeh Daniel Mønsted , Sørensen Lars Tue , Jørgensen Torben
Published: July 2016

Introduction. Symptoms associated with newly formed gallstones have never been studied in a population unaware of their gallstones. The objective of this population-based cohort study was to determine which debut of abdominal symptoms was associated with newly formed gallstones.Materials and Methods. A cohort study was performed of a random sample from general population of Copenhagen. Participants had ultrasound examinations and answered questionnaires about abdominal symptoms at baseline and two reexaminations over 12 years. Participants were not informed of gallstone status. Inclusion criteria were no gallstones or cholecystectomy at baseline and attending a reexamination.Results. Of 3,785 participants, 2,845 fulfilled inclusion criteria. Changes in overall abdominal pain were not significantly different between incident gallstones or gallstone-free participants. Multiple adjusted logistic regression analyses showed that incident gallstones were significantly associated with debut of abdominal pain with projection, localized in the whole upper abdomen, and of longer duration. No significant associations for functional symptoms were identified.Conclusions. A new onset of abdominal pain with projection, localized in the whole upper abdomen, and of longer duration is associated with newly formed gallstones in participants unaware of gallstone status. Functional symptoms should not be the indication for surgical treatment.
Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells
Authors: Collins Cheryl C. , Bashant Kathleen , Erikson Cuixia , Thwe Phyu Myat , Fortner Karen A. , Wang Hong , Morita Craig T. , Budd Ralph C.
Published: July 2016

γδ T cells function at the interface between innate and adaptive immunity and have well-demonstrated roles in response to infection, autoimmunity and tumors. A common characteristic of these seemingly disparate conditions may be cellular stress or death. However, the conditions under which ligands for γδ T cells are induced or exposed remain largely undefined. We observed that induction of necroptosis of murine or human dendritic cells (DC) by inhibition of caspase activity paradoxically augments their ability to activate γδ T cells. Furthermore, upregulation of the stabilizer of caspase-8 activity, c-FLIP, by IL-4, not only greatly reduced the susceptibility of DC to necroptosis, but also considerably decreased their ability to activate γδ T cells. Collectively, these findings suggest that the induction of necroptosis in DC upregulates or exposes the expression of γδ T cell ligands, and they support the view that γδ T cells function in the immune surveillance of cell stress.
Heart Failure with Recovered Ejection Fraction in a Cohort of Elderly Patients with Chronic Heart Failure
Authors: Trullàs Joan Carles , Manzano Luís , Formiga Francesc , Aramburu-Bodas Oscar , Quesada-Simón María Angustias , Arias-Jiménez José Luís , García-Escrivá David , Romero-Requena Jorge Manuel , Jordana-Comajuncosa Rosa , Montero-Pérez-Barquero Manuel ,   on behalf of the investigators from the RICA Registry
Published: July 2016

Objective: The aim of this study was to determine whether patients with heart failure (HF) who recover left ventricular ejection fraction (LVEF), termed here as ‘Rec-HF', have a distinct clinical profile and prognosis compared with patients with HF and reduced LVEF (HF-REF) or HF and preserved LVEF (HF-PEF). Methods: We evaluated and classified patients from the Spanish Heart Failure Registry into three categories based on enrollment/follow-up echocardiograms: HF-PEF (LVEF ≥50%), HF-REF (LVEF persistently <50%) and Rec-HF (LVEF on enrollment <50% but normalized during follow-up). Results: A total of 1,202 patients were included, 1,094 with HF-PEF, 81 with HF-REF and 27 with Rec-HF. The three groups included patients of advanced age (mean age 75 years) with comorbidities. Rec-HF patients were younger, with a better functional status, lower prevalence of diabetes mellitus, dementia and cerebrovascular disease, and higher prevalence of COPD. The etiology of HF was more frequently ischemic and alcoholic and less frequently hypertensive. After a median follow-up of 367 days, the unadjusted hazard ratios for death in the Rec-HF versus HF-PEF and HF-REF groups were 0.11 (95% CI 0.02-080; p = 0.029) and 0.31 (95% CI 0.04-2.5; p = 0.274). Results were statistically nonsignificant in multivariate-adjusted models. Conclusion: Rec-HF is also present in elderly patients with HF but it is necessary to further investigate the natural history and optimal pharmacologic management of this ‘new HF syndrome'.
Giant Cavernous Malformations in Childhood: A Case Report and Review of the Literature
Authors: Ozsoy Kerem Mazhar , Oktay Kadir , Gezercan Yurdal , Cetinalp Nuri Eralp , Olguner Semih Kivanc , Erman Tahsin
Published: July 2016

Cavernous malformations (CMs) of the central nervous system are benign, angiographically occult vascular lesions and are diagnosed by magnetic resonance imaging techniques. Giant CMs do not differ from smaller-sized CMs in their clinical, surgical or histopathological presentation but may be radiologically different. In this paper, we report a 10-year-old male with a giant CM of 8 × 7.5 × 7 cm in diameter that was completely removed by microsurgical treatment. This case addresses important points for practicing neurosurgeons to consider when making a differential diagnosis of large intracranial mass lesions in pediatric patients. In this report, the radiological features of this vascular malformation are described based on a pertinent literature review.
Use the Lower Limit of Normal, Not 80% Predicted, in Judging Eligibility for Lung Resection
Authors: Wesolowski Stefan P. , Boros Piotr W. , Orłowski Tadeusz M. , Quanjer Philip H.
Published: July 2016

Background: Impaired lung function (LF) is a well-known risk factor for perioperative complications in patients qualified for lung resection surgery. The recent European guidelines recommend using values below 80% predicted as indicating abnormal LF rather than the lower limit of normal (LLN). Objectives: To assess how the choice of a cut-off point (80% predicted vs. LLN at -1.645 SD) affects the incidence of functional disorders and postoperative complications in lung cancer patients referred for lung resection. Methods: Preoperative spirometry and the transfer factor for carbon monoxide (TL,CO) were retrospectively analysed in 851 consecutive lung cancer patients after resectional surgery. Results: Airway obstruction was diagnosed in 369 (43.4%), and a restrictive pattern in 41 patients (4.8%). The forced expiratory volume in 1 s (FEV1) or TL,CO was below the LLN in 503 patients (59.1%), whereas the FEV1 or TL,CO was <80% predicted in 620 patients (72.9%; χ2 test: p < 0.0001). In all, 117 out of 851 patients had LF indices <80% predicted but not below the LLN. Odds ratios (ORs) for perioperative complications were higher in patients with impaired LF indices defined as below the LLN (1.59, p = 0.0005) with the exception of large resections (>5 segments). In patients with test results above the LLN and <80% predicted, the OR for perioperative complications was not different (1.14, p = 0.5) from that in patients with normal LF. Conclusions: LF impairments are common in candidates for lung resection. Using the LLN instead of 80% predicted diminishes the prevalence of respiratory impairment by 14% and allows for safe resectional surgery without additional function testing.
Gombrowicz tra esilio e straduzione
Authors: Horn Vera
Published: July 2016

O exílio argentino do escritor polonês Witold Gombrowicz narrado por Laura Pariani no romance La straduzione; a tentativa de traduzir-se; a tentativa de traduzir o Ferdyduke em espanhol para conquistar público; critica e tradução no mundo argentino; a “straduzione” como fracasso.
La prigione e la libertà: due testimonianze del dialogo di Fortini con i classici
Authors: Cataldi Pietro
Published: July 2016

Análise de dois pequenos voluntes de escritos críticos de Franco Fortini: Dialoghi col Tasso (1999) e Le rose dell'abisso (1991), cinco conversas radiofônicas sobre Tasso, Dante, Leopardi, Manzoni e Pascoli.
Dinâmica de Perícia em Local de Crime na Disciplina de Odontologia Forense da FO-USP
Authors: Beaini Thiago Leite , Zanin Alice Aquino , Miranda Geraldo Elias , Flores Marta , Curi Janaina Paiva , Melani Rodolfo F. H.
Published: July 2016

Na disciplina de Odontologia Forense da Faculdade de Odontologia da Universidade de São Paulo (FO-USP), um modelo de ensino construtivista, que se vale de práticas de dinâmica de grupo e de estudo de caso, busca reunir conhecimentos adquiridos na disciplina e em outras matérias que compõem o currículo da graduação em odontologia. Após uma aula expositiva e leitura prévia de uma apostila no ambiente virtual de aprendizagem, os alunos são divididos em equipes e realizam uma dinâmica de “local de crime”, que consiste em observar, descrever, registrar e emitir um relatório estruturado, fatores que se assemelham com o cotidiano clínico do cirurgião-dentista. Atualmente, um número crescente de profissionais vem demonstrando interesse nas carreiras forenses, e a disciplina tem por objetivo preparar o aluno para esse campo de trabalho multidisciplinar. Este relato visa a demonstrar as técnicas utilizadas e os resultados obtidos nos últimos anos com a aula prática pericial em ambiente de graduação.
Sūdābeh and Rūdābeh: Mythological Reflexes of Ancient Goddesses
Authors: Saadi-nejad Manya
Published: July 2016

Many female characters in the Šāhnāmeh are striking for their extraordinary independence and self-assertion, qualities not typically associated with women in the medieval Islamic society in which Ferdowsi lived. This may be an indication that such female figures have superhuman roots, possessing features that may be derived from those attributed to goddesses in ancient mythology. The characters of Sūdābeh and Rūdābeh who can be seen as representing opposing archetypes of feminine power are analyzed in terms of their possible derivations from female divinities in Iranian and Mesopotamian mythology.
Linderiella jebalae sp. nov. (Crustacea: Branchiopoda: Anostraca), a new species from the Rif mountains (northern Morocco)
Authors: BOIX DANI , SALA JORDI , ESCORIZA DANIEL , ALONSO MIGUEL
Published: July 2016

A new species of fairy shrimp, Linderiella jebalae sp. nov., was found in temporary ponds located in the Rif region of northern Morocco. Morphological characters of females, such as the basal long warty outgrowth of the antennae, the highly developed cuticular papillae in the second genital segment, and the presence of a keel-shaped process directed posteriorly in dorsal side of the brood pouch, clearly distinguish this species from the others of the genus. In the case of males, the basiomedial antennal outgrowth and the distal segment of the antenna are diagnostic features for the species. Cyst ornamentation, characterized by thick, blunt and sometimes truncated spines, also separate this species. This is the fourth known Palaearctic Linderiella species, all of them described recently (from 1980s onwards) and located in a restricted area, from south-eastern France to Iberian Peninsula and Morocco.
11-Ketotestosterone Is a Major Androgen Produced in Human Gonads
Authors: Imamichi Yoshitaka , Yuhki Koh-ichi , Orisaka Makoto , Kitano Takeshi , Mukai Kuniaki , Ushikubi Fumitaka , Taniguchi Takanobu , Umezawa Akihiro , Miyamoto Kaoru , Yazawa Takashi
Published: July 2016

Context:

11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans.

Objective:

The objective of this study was to clarify the production and properties of 11-KT in human.

Design, Participants, and Methods:

Expression of cytochrome P450 and 11β-hydroxysteroid dehydrogenase types 1 and 2 (key enzymes involved in the synthesis of 11-KT) were investigated in human gonads. The production of 11-KT was investigated in Leydig cells. Plasma concentrations of testosterone and 11-KT were measured in 10 women and 10 men of reproductive age. Investigation of its properties was performed using breast cancer-derived MCF-7 cells.

Results:

Cytochrome P450 and 11β-hydroxysteroid dehydrogenase types 1 and 2 were detected in Leydig cells and theca cells. Leydig cells produced 11-KT, and relatively high levels of plasma 11-KT were measured in both men and women. There was no sexual dimorphism in the plasma levels of 11-KT, even though testosterone levels were more than 20 times higher in men than in women. It is noteworthy that the levels of testosterone and 11-KT were similar in women. In a luciferase reporter system, 11-KT activated human androgen receptor-mediated transactivation. Conversely, 11-KT did not activate estrogen receptor-mediated transactivation in aromatase-expressed MCF-7 cells, whereas testosterone did following conversion to estrogen. 11-KT did not affect the estrogen/estrogen receptor -mediated cell proliferation of MCF-7 cells. Furthermore, it significantly inhibited cell proliferation when androgen receptor was transfected into MCF-7 cells.

Conclusions:

The current study indicates that 11-KT is produced in the gonads and represents a major androgen in human. It can potentially serve as a nonaromatizable androgen.
Self-Sufficient Healthcare Logistics Systems and Responsiveness: Ten Cases of Foreign Field Hospitals Deployed to Disaster Relief Supply Chains
Authors: Naor Michael , Bernardes Ednilson
Published: July 2016

Recent disasters around the globe illustrate the unpredictability of their timing and the severity of their impact, making aid operations highly uncertain and complex. The aftermath of sudden-impact disasters, such as civil conflicts, wars, and natural disasters, are typically characterized by chaos and the urgent need for medical care for a massive number of casualties; however, damage to local healthcare infrastructures usually render them unable to deliver needed services. Foreign field hospitals, innovative self-sufficient emergency healthcare logistics systems deployed outside the hospitals’ country, constitute a temporary solution until the local facilities are repaired or rebuilt. These types of healthcare logistics system have been deployed with great success. However, not much is known about factors that may account for their success in the supply chain literature. In this study, we investigate military foreign field hospitals and explore general factors that may account for their effectiveness. Specifically, we look into military healthcare logistics systems, specifically foreign field hospitals (FFHs), to explore factors that may account for their responsiveness. We examine ten successful deployments of an experienced and effective military FFH through an exploratory case analysis to shed light into factors that may account for its success. Various propositions and avenues for future research are developed.
Integrating Supply Chain and Production Chain: a Genesis in the Ethanol Industry
Authors: Ferragi Eder Moreno
Published: July 2016

Although frequently used interchangeably, the concepts of supply chain and production chain are considered in this study as two distinct and complementary theoretical frameworks for the conception of a data-mapping model titled SCMap – Supply Chain Map. The model’s objective is to identify and assess real chains of companies and products. An application in the agribusiness sector, starting with a specific sugarcane processing plant and the biofuel ethanol is performed. The SCMap establishes a structured and integrated manner of linking products and companies, considering three different categories of relationships: (1) between companies – supply chain approach; (2) between products – production chain approach, and; (3) between companies and products – regarding commercial practices in the corporate environment. Grounded on Graph Theory and Social Network Analysis – SNA, the software UCINET and NetDraw application are used to draw the maps and quantitatively assess the centrality of each company and product relative to the whole chain.
LINGUAGEM LITERÁRIA E PENSAMENTO: APROXIMAÇÕES TEÓRICO-METODOLÓGICAS À LUZ DA SEMIÓTICA E DA TEORIA HISTÓRICO-CULTURAL
Authors: Furlan de Oliveira MARTA REGINA , MIGLIOZZI FERREIRA MELO LUIZ CARLOS
Published: July 2016

O objetivo deste artigo é analisar aspectos do desenvolvimento das funções psicológicas superiores a partir do uso do texto literário em sala de aula. A análise é feita a partir do diálogo teórico da Semiótica de linha francesa e dos fundamentos da teoria histórico-cultural de Vygotsky, em que pela reflexão e análise, faz uma crítica aos modos como são utilizados os textos no processo de ensino e aprendizagem escolar que acabam inibindo a construção do pensamento elaborado e crítico pelo aluno. Neste artigo, mostram-se, ainda, exemplos de leitura de contos da literatura infantil que podem desenvolver uma ação reflexiva no aluno e, ao mesmo tempo, direcionar o trabalho literário em favor do desenvolvimento das funções psicológicas superiores e do próprio pensamento elaborado enfatizado por Vygotsky (1989) em diálogo com as contribuições da Semiótica literária. A partir desse exercício crítico, podem-se pensar novas alternativas para o trabalho com a linguagem literária na escola em qualquer nível de ensino.
O Uso das Ferramentas na Educação a Distância e o Papel do Tutor
Authors: Dias Auderlânia De Oliveira , Silva Adriana Maria Simião da
Published: July 2016

RESUMO: Este artigo busca apresentar a importância do papel do professor-tutor na modalidade à distância e as ferramentas que a acompanha, considerando sua experiência vivida no decorrer de sua vida acadêmica. Através do surgimento das novas tecnologias a internet tornou-se um meio propício para a difusão do conhecimento, aumentando a oferta de cursos superiores à distância, nesse contexto o tutor é responsável por manter uma comunicação ativa com seus alunos através das ferramentas, por isso propomos neste artigo reflexões que abordem a importância do professor-tutor nessa modalidade, destacando suas principais características e funções e as ferramentas utilizadas no ensino à distância. A metodologia utilizada foi a pesquisa bibliográfica, e teve como  objetivo descrever e analisar o sistema de tutoria na Educação a Distância bem como suas ferramentas , destacando o importante trabalho do professor-tutor, averiguando suas características e suas qualidades .Concluiu- se também que com esse estudo, contribuiu para repensar a função dos tutores presenciais e a distância atuantes na modalidade de ensino à distância ,utilizando-se das ferramentas tecnológicas , tendo em vista que, acreditamos ser de fundamental importância a realização de formação inicial e continuada com esses profissionais, pois são eles que mantêm contato direto e diário com os alunos.
A Gestão e o Uso Racional dos Recursos Hídricos no Município de Juazeiro da Bahia
Authors: Silva Júnior Manoel Faustino Da , Silva Cláudia Maria Lourenço da
Published: July 2016

O presente artigo tem como objetivo avaliar o uso dos recursos hídricos no município de Juazeiro da Bahia junto ao órgão responsável pela sua captação, distribuição e devolução ao meio ambiente. Para tanto, realizou-se pesquisa exploratória qualitativa através de entrevistas com gestores e técnicos de órgãos Federais, Estaduais e Municipais responsáveis pela gestão dos Recursos Hídricos no município. Os resultados permitiram observar que o órgão municipal de gestão de água, mesmo realizando novos investimentos para solucionar os problemas existentes no município e procurando trabalhar de maneira satisfatória, ainda enfrenta complexa gestão requerendo o envolvimento de vários segmentos da sociedade. Ainda, a modernização de tecnologias no interior, à exemplo de irrigação por sistema de irrigação localizada, contribui de forma expressiva para diminuir a degradação ambiental e o bom uso dos recursos hídricos.
Educação Ambiental: Um diálogo entre a legislação e a prática dos professores de escolas públicas de Araripina – PE, 2013-2014
Authors: Nascimento Maria Cristina Delmondes , Rolon Júlio César Cardozo
Published: July 2016

A “Educação Ambiental: Um diálogo entre a legislação e a prática dos professores de escolas públicas de Araripina - Pernambuco, 2013-2014” trata-se de um trabalho investigativo, onde almeja: Discutir como acontece o diálogo entre a legislação e a prática dos professores de duas escolas públicas do município da Araripina – Pernambuco no período de 2013 e 2014.  A pesquisa apresenta uma abordagem de investigação quantitativa. O universo de pesquisa foram as escolas públicas Dionísio Bom de Oliveira e Moisés Bom de Oliveira, tendo como os sujeitos da pesquisa um universo de 45 docentes. Para alcançar os objetivos propostos os mesmos foram entrevistados segundo um roteiro estruturado baseado em um questionário, as respostas foram submetidas à analise temática de conteúdo. A pesquisa comprovou que o diálogo entre teoria e prática nas escolas investigadas necessita de maior efetividade para minimizar as dificuldades para implementação e estímulo a atividades e projetos de Educação Ambiental, que é trabalhada nos temas transversais, sendo ela essencial, principalmente quando é voltada para a formação de valores e que se trata de um processo de educação e reflexão permanente na construção de sujeitos cidadãos.
Enfoque fenomenológico de la crítica arquitectónica
Authors: Navarrete Dra. Arq. Sandra
Published: July 2016

El objetivo central de este trabajo fue definir un método crítico de análisis de la arquitectura que se centre en la experiencia sensible como herramienta de estudio de los aspectos estéticos. Se propone con una validación empírica que permita su generalización. Se realizó un recorte epistemológico situándose en el paradigma posmoderno de la estética. Para la comprensión de los factores que modifican la arquitectura regional, se tomó como objeto de análisis la experiencia espacial de las bodegas de Mendoza. Se sostiene como hipótesis principal que la interpretación crítica de la arquitectura a través de la fenomenología permite un mayor grado de sensibilidad en la concepción de espacios y por lo tanto el aprendizaje de un método de proyecto con aspectos más vinculados al hombre. A partir del análisis realizado de tres bodegas locales con estudiantes de cuarto año de la carrera de arquitectura de la Universidad Nacional de Cuyo, se observó que las vivencias espaciales tienen un alto nivel de pregnancia. Por ello, es posible afirmar que la experiencia sensorial es un aspecto relevante en la formación de una postura conceptual de interés para todas las instancias del proyecto arquitectónico.

Palabras clave

Crítica; Fenomenología; Experiencia sensible; Bodegas
The Educational Theory of John Dewey and its Influence on Educational Policy and Practice in Macedonia
Authors: Miovska-Spaseva Suzana
Published: July 2016

The paper gives an overview of the impact that the educational theory of the American philosopher and educator John Dewey has had on education in Macedonia since the establishment of the educational system after the Second World War. Within this framework two periods are identified and analysed. One refers to forty-five years of socialist development, during which the traces of Dewey’s presence and influence are recognized in the policy documents that shaped the education in the Socialist Republic of Macedonia as part of the former Yugoslav federation. The analysis of the second period covers the last twenty-five years of development of education in the socio-political context of a sovereign state, and is focused on reform initiatives for improving the teaching process introduced in the 90s of the past century. They are marked by the implementation of three major international projects that altered the traditional teaching organization and methodology in elementary and secondary public schools in Macedonia: Active teaching-Interactive learning, Step by step and Reading and writing for critical thinking. The theoretical foundations of these projects are explored, and common elements that can be traced back to Dewey’s educational concepts and values are identified and discussed.
Lernen und Problemlösen: Deweys Psychologie im bildungshistorischen Kontext
Authors: Oelkers Jürgen
Published: July 2016

Karl Popper called one of his latest collections of essays All Life is Problem Solving. Little is known about the history of «problem solving» and also Popper did not say much about his references. But his model of four stages of problem solving is clearly anticipated in John Dewey’s psychology of thinking. On the other hand Dewey’s How we Think (1910) cannot be understood without taken into account the contemporary movement in didactics. The article discusses two of them, «nature studies» on the one hand and the «project method» on the other. «Nature studies» is considered to be the counterpoint to problem-solving. William Kilpatrick’s project method is still closely linked with Dewey’s psychology but both concepts have to be studied independently. Dewey’s theory of problem-solving is a general theory of learning that cannot be reduced to didactics. But that reduction might explain why Popper did not pay attention to it.
Educational-Welfare Policies «in the Name of the Nation»: A Comparative Study in the Greek-Orthodox Communities of Macedonia and Black Sea Region (1860-1923)
Authors: Iliadou-Tachou Sofia
Published: July 2016

This comparative study attempts to describe and interpret the contribution of education and welfare policies to Modern Greek nationalism, focusing on two different contexts: Macedonia and the Ottoman Black Sea region. These two regions were chosen as the main research field for the following reasons: (i) both Macedonia and the Black Sea region were inhabited by a mixed group of Christian, Muslim, Jewish, etc. populations, (ii) the Orthodox populations of both areas fell under the intellectual auspices of the Ecumenical Patriarchate, (iii) the Ottoman reforms were implemented in both areas, and (iv) both regions were influenced by the penetration and dissemination of Modern Greek Nationalism. The main goals of this research were (i) to investigate whether there were any differences between the two contexts during the period mentioned above (1860–1923), (ii) to identify the reasons behind education and welfare policies in Macedonia and the Black Sea region, (iii) to identify the different types of education and welfare policies adopted in Macedonia and the Black Sea region, (iv) to determine the effects of implementation of these policies in each of the two reference frameworks, and (v) to examine whether and how this application of welfare and education policies in each framework was associated with the spread of Modern Greek Nationalism.
Bioinspired engineering polymers by voxel-based 3D-printing
Authors: Swetly Theresa , Stampfl Jürgen , Kempf Gero , Hucke Rainer-Michael , Willing Marcus , Warkentin Marina
Published: July 2016

Additive manufacturing (AM) has become an important tool in the product development process as it offers the possibility to produce parts of good geometrical quality within a short period of time, allowing geometrical validations and the visualisation of ideas. Yet the application of AM is often limited due to the poor mechanical properties of AM parts. In the automotive sector for example, there is a high demand for tough AM parts which have an impact strength comparable to industrially moulded thermoplasts. This paper explores the possibility to increase the impact strength of AM parts by combining a stiff, hard and brittle component (VeroWhite Plus in this instance) with a soft, elastomer-like component (TangoBlack Plus) and arranging these on a micro-scale level in form of alternating, chess-pattern voxels. While one material was responsible for maintaining a sufficient stiffness and strength of the resulting composite structure, the other material acted as an obstacle for crack propagation. Varying the edge length of the voxels, it was possible to investigate the influence of the microscopic voxel geometry on the part’s macroscopic impact strength. It was shown that the Charpy impact strength could be raised by a factor of eight (from 10.9 kJ/m
Biocontrol of Soybean Charcoal Root Rot Disease by Using Trichoderma spp.
Authors: Barari H. , Foroutan A.
Published: July 2016

Macrophomina phaseolina (Tassi) Goid, causing charcoal rot disease of soybean, is one of the major factors threatening soybean production, especially in dry years. This pathogen remains the prevailing causal agent of charcoal rot disease that significantly suppresses the yield of a variety of oilseed crops. Its wide host range and ability to survive under arid conditions, coupled with the ineffective use of fungicides against it, have spurred scientific endeavours for alternative avenues to control this phytopathogen. Hence, the present study aimed to provide empirical evidence of the efficacy of fungal isolates of Trichoderma spp. as biological control agents against charcoal rot in soybean (Glycine max L.). In this study Trichoderma harzianum strains 6, 14, 17, 21, 44, T. asperellum 26 and T. virens 32 were evaluated as potential biological agents for control of this disease. Mycelial growth of M. phaseolina strain h-7 was reduced by cell-free and volatile metabolites of Trichoderma strains by 16.4 to 64.8%. T. harzianum strain Tj17 significantly (p≤0.05) reduced the incidence (to 7.3%) and severity (to 3%) of disease 42 days after inoculation and increased the 1000 grain weight (to 178 g) in greenhouse conditions. For confirmation of the greenhouse tests, the selected antagonists were re-examined in field trials, where this isolate reduced the disease incidence (to 10%) and severity (to 3%). The overall results of this study show high capability of used antagonists in reduction of disease severity and incidence, and resulting in increased weight of the product. Hence, the findings reported in the present study supported the applicability of Tj17 isolate as possible alternative to fungicides for the control of charcoal rot in soybean.
Essential Oil and Microelement Composition of Thymus citriodorus L. and Lippia citriodora H.B.K.
Authors: Kizil S. , Tonçer Ö.
Published: July 2016

Lemon verbena (Lippia citriodora H.B.K., Verbenaceae family) is indigenous to South America and cultivated as an aromatic plant in various parts of world. Lemon thyme (Thymus citriodorus L.), Lamiaceae family, is a perennial medicinal plant native to southern Europe and is cultivated in the Mediterranean region. These species are cultivated mainly for the lemon-like aroma emitted from their leaves due to the presence of dimethyl-2,6- octadienal, also known as lemonal or citral, which is used in food and perfumery for its citrus effect. The aim of this study was to determine the mineral content and essential oil components of L. citriodora and T. citriodorus plants grown under semi-arid climatic conditions in Turkey. The aerial parts of lemon thyme and lemon verbena plants were extracted using hydrodistillation. The essential oil composition was analyzed by gas chromatography-mass spectrometry (GC-MS) and the microelement contents of the herbs were examined via inductively coupled plasmaoptical emission spectrometry (ICP-OES). The microelement contents were 0.249, 1.630, 16.41, 0.106, and 13.1-36.2 mg kg-1 for cadmium (Cd), copper (Cu), iron (Fe), and manganese (Mn), respectively, in lemon thyme, and 0.275, 4.584, 248.1, 15.71, and 1.803 mg kg-1 for Cd, Cu, Fe, Mn, and zinc (Zn), respectively, in lemon verbena. Fifty compounds were identified in lemon verbena essential oil, including limonene (30.33%), trans-citral (17%), cis-citral (12.77%), caryophyllene oxide (5.71%), and geraniol acetate (4.02%) that together constituted 99.86% of the oil composition. We also identified 22 compounds constituting approximately 85.11% of lemon thyme essential oil, including transgeraniol (30.07%), trans-citral (15.06%), cis-citral (11.71%), cis-geraniol (7.65%), and 3-octanol (6.18%).