bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of short-term effect of platelet-rich plasma treatment of tendinosis using texture analysis of ultrasound images
Authors: Pintaric Karlo , Salapura Vladka , Snoj Ziga , Vovk Andrej , Mijovski Mojca Bozic , Vidmar Jernej
Published: December 2023

Background

Computer-aided diagnosis (i.e., texture analyses) tools are becoming increasingly beneficial methods to monitor subtle tissue changes. The aim of this pilot study was to investigate short-term effect of platelet rich plasma (PRP) treatment in supraspinatus and common extensor of the forearm tendinosis by using texture analysis of ultrasound (US) images as well as by clinical questionnaires.

Patients and methods

Thirteen patients (7 male and 6 female, age 36–60 years, mean age 51.2 ± 5.2) were followed after US guided PRP treatment for tendinosis of two tendons (9 patients with lateral epicondylitis and 4 with supraspinatus tendinosis). Clinical and US assessment was performed prior to as well as 3 months after PRP treatment with validated clinical questionnaires. Tissue response in tendons was assessed by using gray level run length matrix method (GLRLM) of US images.

Results

All patients improved of tendinosis symptoms after PRP treatment according to clinical questionnaires. Almost all GLRLM features were statistically improved 3 months after PRP treatment. GLRLM-long run high gray level emphasis (LRLGLE) revealed the best moderate positive and statistically significant correlation after PRP (r = 0.4373, p = 0.0255), followed by GLRLM-low gray level run emphasis (LGLRE) (r = 0.3877, p = 0.05).

Conclusions

Texture analysis of tendinosis US images was a useful quantitative method for the assessment of tendon remodeling after minimally invasive PRP treatment. GLRLM features have the potential to become useful imaging biomarkers to monitor spatial and time limited tissue response after PRP, however larger studies with similar protocols are needed.
Quantitative SSTR-PET/CT for predicting response and survival outcomes in patients with pancreatic neuroendocrine tumors receiving CAPTEM
Authors: Ingenerf Maria , Karim Homeira , Auernhammer Christoph , Zacherl Matthias , Wenter Vera , Winkelmann Michael , Ricke Jens , Berger Frank , Schmid-Tannwald Christine
Published: December 2023

Background

This study aimed to evaluate the predictive and monitoring role of somatostatin receptor (SSTR) positron emission tomography-computed tomography (PET/CT) and clinical parameters in patients with neuroendocrine liver metastases (NELM) from pancreatic neuroendocrine tumors (pNET) receiving capecitabine and temozolomide (CAPTEM).

Patients and methods

This retrospective study included twenty-two patients with pNET and NELM receiving CAPTEM who underwent pre- and post-therapeutic 68Ga-DOTATATE/-TOC PET/CT. Imaging (including standardized uptake value [SUV] of target lesions [NELM and pNET], normal spleen and liver) and clinical (Chromogranin A [CgA], Ki-67) parameters were assessed. Treatment outcome was evaluated as response according to RECIST 1.1, progression free survival (PFS) and overall survival (OS).

Results

The median PFS (mPFS) was 7 months. Responders had a significantly longer mPFS compared to non-responders (10 vs. 4 months p = 0.022). Median OS (mOS) was 33 months (mOS: responders = 80 months, non-responders = 24 months p = 0.182). Baseline imaging showed higher SUV in responders, including absolute SUV, tumor-to-spleen (T/S), and tumor-to-liver (T/L) ratios (p < 0.02). All SUV parameters changed only in the responders during follow-up. Univariable Cox regression analysis identified baseline Tmax/Smean ratio and percentage change in size of pNETs as significant factors associated with PFS. A baseline Tmax/Smean ratio < 1.5 was associated with a shorter mPFS (10 vs. 4 months, (p < 0.05)). Prognostic factors for OS included age, percentage change in CgA and in T/S ratios in univariable Cox regression.

Conclusions

SSTR-PET/CT can be useful for predicting response and survival outcomes in pNET patients receiving CAPTEM: Higher baseline SUV values, particularly Tmax/Smean ratios of liver metastases were associated with better response and prolonged PFS.
Imaging microvascular changes in nonocular oncological clinical applications by optical coherence tomography angiography: a literature review
Authors: Hren Rok , Sersa Gregor , Simoncic Urban , Milanic Matija
Published: December 2023

Background

Optical coherence tomography angiography (OCTA) is an emerging imaging modality that enables noninvasive visualization and analysis of tumor vasculature. OCTA has been particularly useful in clinical ocular oncology, while in this article, we evaluated OCTA in assessing microvascular changes in clinical nonocular oncology through a systematic review of the literature.

Method

The inclusion criterion for the literature search in PubMed, Web of Science and Scopus electronic databases was the use of OCTA in nonocular clinical oncology, meaning that all ocular clinical studies and all ocular and nonocular animal, phantom, ex vivo, experimental, research and development, and purely methodological studies were excluded.

Results

Eleven articles met the inclusion criteria. The anatomic locations of the neoplasms in the selected articles were the gastrointestinal tract (2 articles), head and neck (1 article) and skin (8 articles).

Conclusions

While OCTA has shown great advancements in ophthalmology, its translation to the nonocular clinical oncology setting presents several limitations, with a lack of standardized protocols and interpretation guidelines posing the most significant challenge.
The Impact of a Permeation Grouting Technique Quantitatively Assessed Through a Process-Focused Life Cycle Assessment
Authors: Pettinaroli Andrea , Susani Stefano , Castellanza Riccardo , Collina Elena Maria , Pierani Matteo , Paoli Riccardo , Romagnoli Francesco
Published: December 2023

Permeation grouting treatments can be considered a well-established ground improvement strategy in urban built environments, where an accurate fine-tuning of its components can lead to tailored and efficient interventions. However, how to improve its overall environmental impact remains an open question. Using the Life Cycle Assessment (LCA) approach emphasizing the construction phase, this research highlights the leverages that can improve the environmental performance of this geotechnical construction process. The alternative approaches in terms of materials and processes are identified, quantified, and compared using the standard output of the LCA analysis and represent the ideal input for the three-phased sustainability assessment method for geotechnical infrastructure developed by the authors.
Some Remarks on Leibniz’s Idea of Thinking as Computation
Authors: Święczkowska Halina
Published: December 2023

The idea of automation of reasoning in science, which is extremely high-ranking nowadays in connection with the development of computer technology and research into artificial intelligence has been presented in the history of mind since taking up a cohered with the idea of mechanization of reasoning. It is therefore proper to present the greatest enthusiast every of this idea on the threshold of the contemporary science, who treated the idea of mechanization in reasoning very widely, assuming that every mind process can be expressed in some physical manner – Gottfried Wilhelm Leibniz.
(Hiper)vulnerabilidade dos usuários de ambientes digitais
Authors: Brencis Guimarães Nádia Carolina , Amaral Ana Cláudia Corrêa Zuin Mattos do
Published: December 2023

O Código de Defesa do Consumidor tem como princípio a vulnerabilidade dos consumidores em razão da assimetria contratual. No entanto, o desequilíbrio contratual é mais acentuado quando imersos em ambientes digitais, como o metaverso, em razão do tratamento de dados pessoais pelos fornecedores. Propõe-se analisar se há hipervulnerabilidade dos usuários por limitações à autodeterminação informativa, e como equalizar a relação consumidor-fornecedor. Conquanto o consentimento, na LGPD, seja uma das bases legais para o tratamento de dados, há dificuldades para que seja livre e esclarecido, decorrentes da ausência de compreensão adequada das consequências do tratamento de dados. Utilizando-se de pesquisa teórico-bibliográfica e dedutiva identificou-se que a condição de hipervulnerável corresponde à uma vulnerabilidade maior devida a condições pessoais, que deixam a pessoa mais exposta à lesão, exigindo do fornecedor uma conduta mais cuidadosa. E a utilização do metaverso potencializará a coleta de dados pessoais pela observação. Embora seja possível identificar este nível maior de vulnerabilidade dos usuários de ambientes digitais sob um viés objetivo, ou seja, todos os usuários são hipervulneráveis em razão da inferioridade informacional, é possível também identificar um viés subjetivo, fundamentado na condição pessoal do usuário que o torne mais suscetível à lesão. Independentemente da concepção, exige-se do fornecedor e do Poder Público condutas proativas direcionadas ao empoderamento dos usuários para exercerem a autodeterminação informativa, tanto pela própria arquitetura dos ambientes virtuais quanto por Políticas Públicas de esclarecimento aos usuários sobre as implicações do tratamento de dados pessoais.
Palavras-Chave: Hipervulnerabilidade. Metaverso. Proteção de dados pessoais.
Vergils Œuvre - Die Trias und ihre Appendices
Authors: Zogg Fabian
Published: December 2023

Vergil verband seine Eklogen, Georgica und Aeneis so geschickt zu einer Einheit, dass Autoren wie Properz und Ovid bei der Konzeption eigener Gesamtwerke vor einer Herausforderung standen. Daneben sind ab dem 1. Jahrhundert nach Christus angeblich vergilische Jugendwerke bezeugt,die heute mit dem Titel Appendix Vergiliana bezeichnet werden und im Mittelpunkt der Studie stehen. Diese vergilischen iuvenilia bildeten keine konstante Sammlung; vielmehr wurde Vergils Trias im Laufe der Zeit durch unterschiedliche Appendices ergänzt. Dies zeigt sich nicht nur in derantiken und mittelalterlichen Rezeption, sondern auch in den Handschriften selbst. Dank einer neuen Erklärung der komplexen Überlieferung lassen sich die Veränderungen von Vergils Œuvre in diesen materiellen Textzeugen endlich besser verstehen.
L’éducation religieuse par les symboles - Une chance pour le dialogue interconvictionnel et interreligieux ?
Authors: Legrand Geoffrey
Published: December 2023

L’usage de symboles dans l’éducation religieuse peut-elle servir la formation au dialogue interconvictionnel et interreligieux ? Pour répondre à cette question, l’auteur de ce livre examine plusieurs concepts – « expérience », « dialogue », mais aussi « Salut » et « Révélation » – du point de vue de la théologie chrétienne. Il présente divers modèles d’éducation religieuse, anciens ou contemporains, en portant une attention particulière à la place occupée par les symboles. L’enquête se veut un plaidoyer pour le développement d’une grammaire du symbolique et une invitation au développement des pédagogies interreligieuses, dans le but d’apprendre aux élèves à construire ensemble le monde de demain.
Sakrament des gegenwärtigen Augenblicks - Ein Klassiker und seine Alltagsmystik in theologischer Relecture
Authors: Höffner Michael
Published: December 2023

Die Studie erschließt den Klassiker «L’Abandon à la Providence divine» aus dem frühen 18. Jahrhundert. Mit der Rede vom «Sakrament des gegenwärtigen Augenblicks» inspiriert seine Alltagsmystik bis in die Gegenwart hinein bedeutende Denker und Denkerinnen. Den neueren hermeneutischen Standards folgend nimmt der Autor den Zeitindex ernst und erkundet den ursprünglichen Sitz im Leben. Da es bis in die Gegenwart hinein wenige kritische Studien zur Theologie des Traité gibt, fördert eine aufmerksame Lektüre des Textes die theologieimprägnierten Schlüsselthemen zutage (z. B. Vorsehung, Hingabe). Damit ist der Weg geebnet für eine relecture, die zunächst, die Schlüsselthemen betreffend, zeitdiagnostisch den Gegenwartshorizont befragt, und schließlich mit dem Traité weiterdenkt, indem sie versucht, eine Alltagsmystik theologisch neu zu begründen und zu entwickeln – als Stil des Christseins für die Gegenwart.
ПЕДАГОГІЧНІ УМОВИ ПІДГОТОВКИ ВЧИТЕЛІВ ДО РОЗВИТКУ ГРОМАДЯНСЬКОЇ КОМПЕТЕНТНОСТІ УЧНІВ БАЗОВОЇ СЕРЕДНЬОЇ ОСВІТИ
Authors: Ратушняк Наталія
Published: December 2023

У статті означено педагогічні умови підготовки вчителів у системі післядипломної педагогічної освіти до розвитку громадянської компетентності учнів базової середньої освіти. Обґрунтовано, що ефективність формування громадянської компетентності в педагогів залежить від створення спеціальних організаційних і педагогічних умов. Охарактеризовано їхню сутність, виокремлено та розкрито складові. Вказано на специфіку відбору засобів діяльності і технічного супроводу, які сприятимуть формуванню громадянської компетентності педагогів. Уточнено зміст громадянської компетентності педагога. Розглянуто форми та методи формування громадянської компетентності педагога, а також структуру навчально-методичного забезпечення.
СУТНІСТЬ І ЗМІСТ ІННОВАЦІЙ ТА ІННОВАЦІЙНИХ ПРАКТИК У НЕФОРМАЛЬНІЙ ТА ІНФОРМАЛЬНІЙ ОСВІТІ
Authors: Піддячий Володимир
Published: December 2023

У статті розкриваються сутність і зміст інновації та інноваційних практик у неформальній та інформальній освіті. Акцентовано, що поступ суспільства та держави зумовлений випереджальним розвитком освітньої і наукової сфери, формуванням гармонійної особистості з високим рівнем самоорганізації. Вказано на важливість інновацій у модернізації та реформуванні освіти. Розкрито сучасні інноваційні практики у сфері неформальної та інформальної освіти з урахуванням їхньої сутності і специфіки. Зазначено, що інновації є результатом творчої діяльності особистості, і у зв’язку з цим важливо забезпечувати умови для її гармонійного професійного й особистісного розвитку. Виокремлено сутнісні ознаки та види інноваційних продуктів, вказано на основні напрями інноваційної діяльності у неформальній та інформальній освіті. Розглянуто вагомі інноваційні теорії і технології навчання ХХ та ХХІ ст. Виокремлено основні види інноваційної діяльності. Вказано на послідовність дій у розроблені інновацій у сфері неформальної та інформальної освіти. Зазначено основні проблеми на етапі створення інновацій та їхні наслідки.
ВИКЛАДАННЯ ОСНОВ АНАЛІЗУ ДАНИХ У КУРСІ “МОДЕЛЮВАННЯ ТА ПРОГНОЗУВАННЯ СТАНУ ДОВКІЛЛЯ”
Authors: Сеньків Віктор
Published: December 2023

У статті розглянуто аспекти навчання обробки та опрацьовування даних під час підготовки фахівців-екологів. Показано, що зазвичай навчання здійснюється під час викладання курсу “Моделювання та прогнозування стану довкілля”, і суміжних курсів. Аналіз і обробка даних викладається як частина цього курсу та є необхідною складовою побудови математичних моделей. Водночас обробка даних передбачає розв’язання інших завдань: групування, візуалізація, побудова залежностей, пошук прихованих зв’язків, відкриття нової інформації, пошук зв’язку між даними та просторовим розташуванням. Для навчання розв’язувати вказані завдання запропоновано розширити інструментарій проведення практичних та лабораторних занять шляхом виконання завдань з допомогою різних типів спеціалізованого програмного забезпечення.
РОЗВИТОК ТВОРЧОСТІ УЧНІВ 4 КЛАСУ НА УРОКАХ МИСТЕЦТВА В УМОВАХ ОНЛАЙН-НАВЧАННЯ
Authors: Скакодуб Оксана , Шпіца Роксолана
Published: December 2023

У статті розглянуто наукову проблематику розвитку творчості учнів початкових класів під час онлайн-навчання. Виокремлено інструментарій та розглянуто відповідні вебресурси. Доведено важливість використання сучасних комп’ютерних засобів у навчальній практиці школи. Зазначено, що впровадження інформаційно-комунікаційних технологій у навчальний процес відкриває перспективи для розвитку творчості здобувачів освіти. Виявлено і проаналізовано комп'ютерні програми, мобільні додатки та мистецькі лабораторії, які можна ефективно використовувати на уроках мистецтва у початковій школі в умовах війни. Уточнено використання їх на уроках інтегрованого курсу “Мистецтво”. Окреслено варіативність у практичних застосуваннях для урізноманітнення завдань та вправ на уроці мистецтва. Розглянуто особливості використання їх на дистанційних уроках з мистецтва. Спираючись на науково-педагогічні джерела, встановлено недостатню розробленість окресленої проблематики. Відтак, постає необхідність розширення варіантності вправ та завдань для розвитку творчості молодших школярів в умовах війни і розроблення алгоритму проведення дистанційних уроків мистецтва.
РОЗВИТОК ЗДОРОВ’ЯЗБЕРЕЖУВАЛЬНОГО МИСЛЕННЯ МАЙБУТНІХ ФАРМАЦЕВТІВ У СИСТЕМІ ПІСЛЯДИПЛОМНОЇ ОСВІТИ
Authors: Артюшенко Андрій
Published: December 2023

У статті визначено й охарактеризовано провідні тенденції розвитку фармацевтичної галузі України, висвітлено теоретичні аспекти і практичний досвід реалізації здоров’язбережувального мислення майбутніх фармацевтів в умовах післядипломної освіти. Зауважено, що пошук методологічного підґрунтя розвитку здоров’язбережувального мислення є особливо актуальним і перспективним завданням багатоаспектних функцій та завдань післядипломної освіти в теоретичній та практичній площинах. З’ясовано, що наскрізним у формуванні змісту фармацевтичної освіти є глибоке розуміння цінності людини та її здоров’я як найвищого особистісного і суспільного надбання.
ВИКОРИСТАННЯ ПЕДАГОГІЧНИХ ЗАДАЧ У ПІДГОТОВЦІ МАЙБУТНІХ ВЧИТЕЛІВ ІНОЗЕМНОЇ МОВИ ДО РОЗВИТКУ В УЧНІВ СОЦІАЛЬНОЇ КОМПЕТЕНТНОСТІ
Authors: Афонченко Марина
Published: December 2023

У статті досліджено питання особливостей використання у підготовці вчителів педагогічних задач. Проаналізовано праці, що висвітлюють, як педагогічні задачі пов’язані із педагогічним мисленням, педагогічною майстерністю та педагогічною технологією. Досліджено, які класифікації педагогічних задач існують на сьогодні та складено власну класифікацію педагогічних задач за їхніми функціями, а також додано характеристику кожного виду задач та наведено їх приклади. Проведено дослідження із використання задач для студентів другого курсу у процесі їхньої підготовки до розвитку в учнів соціальної компетентності.
ЦІННОСТІ ЯК ДЖЕРЕЛО ПРОФЕСІЙНОЇ ПІДГОТОВКИ СТУДЕНТІВ ВИЩИХ ТЕХНІЧНИХ ЗАКЛАДІВ ОСВІТИ
Authors: Ісаєва Оксана , Шайнер Ганна
Published: December 2023

Стаття присвячена проблемі формування цінностей у студентів майбутніх технічних спеціальностей під час навчально-пізнавальної діяльності.

Формування ціннісних орієнтацій студентів відбувається лише у процесі навчальної діяльності, оскільки цей процес пов’язаний з системою відносин, до якої залучений суб’єкт. Тому формування ціннісних орієнтацій студентів треба розглядати як процес засвоєння ними суспільних цінностей, знань, соціальних норм і правил, що можливо лише при науково-організаційному забезпеченні аксіологічного підходу до професійної підготовки студентів технічних закладів. Власне психолого-педагогічний аспект теорії цінностей корелює з культурологічним аспектом у процесі формування майбутнього фахівця.
СИСТЕМА ВИЩОЇ ОСВІТИ В САУДІВСЬКІЙ АРАВІЇ ТА УКРАЇНІ: ПОРІВНЯЛЬНИЙ АНАЛІЗ
Authors: Мартинюк Анатолій , Онищенко Наталія
Published: December 2023

У статті проаналізовано загальні відмінності, проблеми та визначено перспективи вищої освіти в Україні та Саудівській Аравії у контексті глобальних трансформацій сучасного освітнього простору.

Наголошується, що вища освіта в нових соціально-економічних умовах набуває високого статусу, саме вона сприяє переходу до інформаційного суспільства, визначаючи пріоритети розвитку cучасної європейської правової держави, в якій основним стратегічним резервом є високоосвічена молодь.

Порівняльний аналіз розкриває особливості системи вищої  школи України та Саудівської Аравії, визначено недоліки та переваги кожної із систем.
Perbedaan Kepatuhan Penerapan Protokol Kesehatan di Tingkat Pendidikan SLTP dan SLTA saat PTM Terbatas
Authors: Maharjo Wiwin Dwi Astuti , Trisetiyaningsih Yanita
Published: December 2023

Compliance has become one important thing in implementing health protocol during the covid-19 pandemic period. It is the key of success for some schools or education institutions in applying the regulation of limited face-to-face learning (PTMT) during the pandemic. PTMT regulation has been implemented to support the teaching and learning process when the students were at schools. In the implementation of the program, there were some schools, Junior High School (SLTP) and Senior High School (SLTA), both public and private, where the students did not obey the health protocol regulation and there were incomplete supporting facilities available at the schools. This research aims at finding out the differences between health protocol implementation compliance in SLTP and SLTA during PTMT.

Methods: The design of the research was comparative descriptive utilizing quantitative technique. The sampling applied stratified random sampling technique. The total respondents were 100 students where 25 students were taken from each school. The data collection used observation, demographic data, and implementation of health protocol compliance questionnaire. The data analysis applied Mann-Whitney’s test. The differences in compliance level shows p-value score of 0.512 > 0.05 indicating that the compliance levels in SLTP students, both public and private, are not different. The p-value score of 0.274 > 0.05 means that there is no different compliance level in SLTA students, both public and private. The p-value score of 0.464 > 0.05 indicates that there is no different compliance level in SLTP and SLTA students. There is no different compliance level in public and private SLTP students during PTMT, there is no different compliance level in public and private SLTA students during PTMT, and there is no different compliance level in SLTP and SLTA students during PTMT.
Dukungan Informatif Keluarga Berhubungan dengan Kejadian Hipertensi pada Lansia
Authors: Bobu Lazandi Rawa , Putri Rona Sari Mahaji , Ka’arayeno Arie Jefry
Published: December 2023

The incidence of hypertension in the elderly is increasing day by day. Family informative support is needed as an effort to help maintain blood pressure in the elderly to remain stable, in addition to a healthy lifestyle and medication. The purpose of this study was to link informative family support with the incidence of hypertension in the elderly. Cross-sectional design, with sa sample of 42 elderly using 'simple random sampling technique'. The instruments were an informative family support questionnaire and an observation sheet for hypertension. Fisher's exact test was used for data analysis. The results illustrate that most of the respondents have less informative family support (57.1%), most of the respondents have stage 3 hypertension (52.4%) and family informative support correlates with 'hypertensive incidence' of the elderly in Posyandu Kemala, Klojen District, Malang City (p value = 0.000). It is recommended that further researchers examine various factors that influence the incidence of hypertension.
Internalization of Animal Welfare Norms: Legal Protection Against Animal Mistreatment
Authors: Setiabudhi Donna Okthalia , Irwansyah Irwansyah , Yunus Ahsan
Published: December 2023

Animal welfare has important aspects in measuring the effect on animals in different situations and environments from an animal’s point of view. Ignoring animal welfare, both livestock and slaughter animals will lead to fear, stress and pain in animals during the process of slaughtering, transporting, marketing and supplying poor feed and water. The type of research is socio-juridical, carried out in North Sulawesi Province with the practice of slaughtering animals which was considered sadistic and received international criticism. The results show that the efforts to protect animals in order to realize animal welfare can be carried out by establishing laws and regulations. Specifically, regulate animal protection so that disharmony does not occur with the substance of the law, multiple interpretations. Animals, in this sense, are subjects for the spread of disease, rather than as objects for contracting the disease, especially from humans. In Indonesia, factors that cause weaknesses in animal protection are sanctions applied, the lack of knowledge and understanding of law enforcement officials.
Factors Predicting the Adaptation of Studens Attending National Defense and Security Education at VNU National Defense and Security Traning Cennter
Authors: Thi Phuong Thao Nguyen , Anh Nguyen Thi Lan
Published: December 2023

Adaptation is important for all students attending universities. Students with a good and fast adaptation will help promote their own strengths and achieve high learning results. The study aimed to analyze the adaptation of students attending National Defense and Security Education at VNU National Defense and SecurityTraining Center and analyze the factors predicting the adaptation of students attending National Defense and Security Education at the Center. Through the quantitative research method with a research sample of 300 students taking the course National Defense and Security Education at the Center, the research results show that the factors belonging to students, the factors belonging to VNU National Defense and Security Training Center and family and social factors have different influences on the adaptability of students taking the course National Defense and Security Education at the Center. In particular, family and social factors have a great influence on the level of adaptation in students taking the course National Defense and Security Education at the Center. From there, the study proposes solutions to improve the adaptability of students taking the course National Defense and Security Education at the Center in the coming time.
Training Collaboration in the Field of National Defense and Security Education at Vietnam National University, Hanoi
Authors: Ngoc Sang Tran , Ha Nguyen Manh
Published: December 2023

Before the new demands and tasks of safeguarding the Fatherland in the new situation, the education and cultivation of national defense and security knowledge is the right and responsibility of every citizen. Accordingly, students from colleges, universities nationwide in general, and the Hanoi region in particular, need to be educated to enhance their awareness of the Party's direction and the work of national defense and security, as well as the necessary and appropriate military knowledge and skills, to be ready to participate in fulfilling military duties when necessary. VNU National Defense and SecurityTraining Center, with its assigned functions and tasks, carries out the regular and important mission of organizing the linkage of national defense and security education with affiliated units according to the categorization of the Ministry of National Defense. Since its establishment until now, VNU National Defense and SecurityTraining Center has consistently organized the effective coordination of training in the field of national defense and security education for students from educational institutions in various categories, with tens of thousands of courses to meet training objectives and requirements, successfully completing the mission. Alongside the achieved results, the implementation process has encountered limitations and shortcomings that have had a certain impact on overall activities. This places a demand on VNU National Defense and SecurityTraining Center to continue researching content and methods for better implementation of training linkage with affiliated units, contributing to the enhancement of training quality.
¬The Development of Student Collaboration Competency in Learning National Defense Path of the Vietnamese Communist Party
Authors: Thanh Nghia Duong , Hoai Vu Thi Thu
Published: December 2023

Cooperation competency is not only one of the many vital capabilities for people living in the modern day society, but also assists the formulation of an energetic, creative, communicative and adaptive personality. There has been ample evidence on the fact that studying with continuous cooperative work can promote the growth of working skills, which in turn creates opportunities for mutual learning and the discovery of personal abilities. Furthermore, cooperation also helps enhance the sense of responsibility, autonomy and social activeness. Through group work, people can take advantage of their strength in numbers to resolve complicated matters and achieve significant results. This proves the essential role of cooperation competency in creating an all-round personality and developing such traits in the contemporary society - this is the basis for academic achievement. This article defines the framework of students’ cooperation competency in learning National Defense and Security (NDS), investigates the ongoing situation of teaching National Defense Path of the Vietnamese Communist Party (VCP) and suggests several solutions to further boost this characteristic while studying these subjects in accordance with current requirements on reforming the education system of Vietnam.
Evaluation of the Students’s Satisfaction with the Assessment Activities of the National Defense and Security Education Course Results: Case Study at the National Defense and Security Trainning Center, Vietnam National University, Hanoi
Authors: Thanh Tung Tran , Hoang Le Sy Nguyen
Published: December 2023

The research want to evaluate the students’s satisfaction in testing the national defense and security education course results at the VNU National Defense and Security Trainning Center, Vietnam National University, Hanoi. The data was collected from 420 Vietnam Women’s Academy’s students that were studying at the VNU National Defense and Security Trainning Center, Vietnam National University, Hanoi. The result of Cronbach Alpha has shown there are total 5 factors affecting student satisfaction, including: i) Training program; ii) Assessment organization; iii) Teaching staff; iv) Facilities; and v) Test results. In general, students were satisfied with the activities of testing and evaluating the results of defense and security education subjects, in which the teaching staff received the highest satisfaction from students.
The intertextuality of visual and verbal works by naive artist Nadezhda Spirina
Authors: Sholicheva Anastasiya
Published: December 2023

In modern humanities, it is customary to consider naive art and naive literature as two separate phenomena. Based on this approach, the study of naive fine art is given over to art criticism, and the study of naive literature remains within the framework of philology and linguistics. Culturology explores culture as the historical and social experience of people, which can manifest itself in their work and is interpreted in the "cultural texts" of art. This article actualizes the need to move from narrowly focused research to a comprehensive approach: contextual study of visual and verbal works of naive artists. The objects of this study are paintings and poems by the naive artist Nadezhda Spirina (Ivanovo region, the city of Yuzha). The subject of the research is the aesthetics and poetics of the intertextuality of the works of a naive artist. The aim of the work is to analyze the stylistics and composition of paintings in combination with the poetic texts of the author. Tasks – search for intertextual references and reminiscences in the works of N. Spirina, the disclosure in her works of various practices of the author's self-reflection, testing the hypothesis of expanding the status of the work of a naive artist as a cultural text, taking into account the semantic features of verbal utterance for the perception and reading of the visual text, that is, the intertextuality of works of naive art. Synchronistic, comparative, biographical, psychological, semiotic, cultural and historical analysis are used. The scientific novelty of the research lies in the analysis of the stylistics and composition of the paintings of a naive artist in combination with the poetic texts of the author, which makes it possible to more accurately interpret the artist's mission, which forms his naive utterance.
Temperature compensated crystal oscillator design in Keysight ADS
Authors:   Omsk State Technical University, Lyashuk A. N. , Kosykh A. V. ,   Omsk State Technical University
Published: December 2023

The article proposes an all-embracing approach to designing a temperature compensated crystal oscillator in Keysight ADS CAD system, which allows: to investigate the conditions for the occurrence of self-oscillations in a given oscillator circuit; analyze the temperature-frequency characteristics of the resonator; form requirements for the frequency control function; simulate noise characteristics of the generator; optimize the circuit according to the given parameters. In contrast to the well-known numerical design of a thermally compensated crystal oscillator in SPICE programs with subsequent analysis of the results in a mathematical program, for example, Mathcad, the proposed method allows us to investigate the real shape of oscillations, the spectral purity of the output signal, take into account the nonlinear influence of the circuit and more subtle effects.
Results of a study on combustion of solids in an enclosed volume
Authors:   Siberian Fire and Rescue Academy of the State Fire Service of the EMERCOM of Russia, Makarova T. P. , Baturo A. N. ,   Siberian Fire and Rescue Academy of the State Fire Service of the EMERCOM of Russia, Bezborodov Yu. N. ,   Siberian Fire and Rescue Academy of the State Fire Service of the EMERCOM of Russia
Published: December 2023

The paper presents the results of laboratory experiments to study the parameters of the gas environment during the combustion of wood, rubber and plastic under conditions that exclude oxygen access to the reaction area. A laboratory bench has been developed to create the conditions. Graphs of temperature changes and reduction of light transmission of combustion products accumulated in the upper part of the combustion chamber layer have been obtained. Changes of the controlled parameters are analysed and correlation dependences between them are obtained. The results obtained can be used as estimates for building prediction models of fire development in enclosed storage rooms, as well as for assessing the fire hazard of substances when burning in an enclosed volume.
The problem of reduction of geometry and graphic training departments in Russian universities
Authors:   Nizhny Novgorod State University of Architecture and Civil Engineering, Rotkov S. I. , Konopatskiy E. V. ,   Nizhny Novgorod State University of Architecture and Civil Engineering, Panchuk K. L. ,   Omsk State Technical University
Published: December 2023

In the article the authors raised the problem of reduction of geometry-graphic training departments in Russian universities, which for the last 16 years amounted to about 1/3. The reasons for this situation are considered, among which should be emphasized the lack of highly qualified personnel of higher qualification, capable of leading scientific schools in the profile of geometric-graphic training departments. It is proposed to activate the work of the departments of geometry-graphic training on training of scientific-pedagogical staff of higher qualification in postgraduate and doctoral studies. It is also proposed to fix for engineering specialties at the level of the state standard the necessary labor intensity and more stringent requirements to the staff conditions for the implementation of the basic professional educational program with regard to the disciplines of geometric-graphic training of students.
Selection of dust cleaning equipment such as cyclone for metalworking industries using the Hierarchy Analysis Method
Authors:   Omsk State Technical University, Solomin V. Yu. , Belkova S. V. ,   Omsk State Technical University, Solomin V. Yu. ,   Children's Municipal Clinic No. 8
Published: December 2023

Metalworking is the main industrial production and its technological process requires dust cleaning. The choice of dust-collecting units from a trivial approach turns into a compact-multi-criteria one and requires the study of methods for its implementation. This article uses the method of selection of dust-cleaning equipment of cyclone type based on dust from metalworking industries based on the Hierarchy Analysis Method.
The surface of non-linear rotation
Authors:   Omsk State Technical University, Panchuk K. L. , Myasoyedova T. M. ,   Omsk State Technical University
Published: December 2023

The paper considers a geometric scheme, a mathematical model and an algorithm for shaping a non-linear rotation surface. It is known that in Euclidean geometry and mechanics the transformation of rotation is linear, while distance and angle are its invariants. The authors proposed a geometric scheme of non-linear rotation, in which the axis of rotation is a smooth spatial curve and the object of rotation is a smooth line. Several propositions, a lemma and a theorem are proved, which allow one to form the initial data in the problem of nonlinear rotation, the solution of which is the parametric equations of smooth surfaces. The research results make it possible to expand the variety of cyclic surfaces in the existing classification of analytic surfaces. They can also be useful in the creation of CAD, which provides for the design of surface forms of products for mechanical engineering, construction, architecture and other practical areas based on cyclic surfaces.
Construction of the control algorithm to improve energy efficiency of a switched reluctance electric motor
Authors:   Rostov State Transport University, Kashuba А. V. , Shevkunova А. V. ,   Rostov State Transport University
Published: December 2023

An energy-efficient switched reluctance electric drive is considered in relation to electric rolling stock. It fully meets such requirements as good adjustment properties, high energy efficiency and operational reliability. The scientific and technical value of the results of the work lies in the development of an algorithm for controlling a traction switched reluctance motor that reduces the operating current while providing the necessary power. The calculations are made by means of specialized programs interacting with each other FEMM and MATLAB. The materials of this study are of practical value for improving the operational and technical and economic indicators of electric rolling stock.
The analysis of continuous admissible currents and active power losses in overhead power lines taking into account climatic factors
Authors:   Omsk State Technical University, Petrova E. V. , Girshin S. S. ,   Omsk State Technical University, Krivolapov V. A. ,   Omsk State Technical University, Goryunov V. N. ,   Omsk State Technical University, Trotsenko V. M. ,   Omsk State Technical University
Published: December 2023

Formulas for calculating continuous admissible currents and active power losses for overhead power transmission lines under conditions of natural and forced convection for insulated and non-insulated conductors are presented. The correct determination of maximum current loads plays an important role in the efficient use of the load capacity of power transmission lines, and the refinement of the calculation of active power losses is the basis for increasing the efficiency of energy transmission. The results obtained can be used in the selection of measures aimed at increasing the capacity of overhead lines and reducing energy losses.
סיפורו של מחמד אל־מצרי : צוהר להפעלת "ציידי הטנקים" במלחמת יום הכיפורים
Authors: Cohen Dikla
Published: December 2023

This article sheds light on the story of Muhammad al-Masri, an Egyptian war hero, who served as a “tank hunter” and destroyed 27 Israeli tanks during the October War of 1973. Al-Masri symbolizes the boldness of the Egyptian soldiers who fought against Israel, as well as the success of the surprise moves that were planned by the Egyptian generals and caught the Israeli soldiers off guard in the first stage of the war. The article will present a thorough discussion of Egyptian combat doctrine, the training of the “tank hunters,” and the character of the Egyptian model of heroism. These doctrines and models will be demonstrated through reference to encounters between Egyptian and Israeli soldiers in the very first clashes of the war, especially al-Masri’s encounter with the Israeli anti-hero lieutenant colonel Asaf Yaguri, who was captured by the Egyptians immediately after the destruction of his tank by al-Masri. These concepts will also be examined in view of the portrayal of decorated soldiers and officers in the Egyptian discourse and media. Thus, this article seeks to illuminate factors that may partly explain the nature of the “cold peace” between Egypt and Israel.
Targeted Photodynamic Therapy: Gluconamide-Modified Cellulose Nanocrystals as Efficient Photosensitizer Delivery Platforms Against Gram-Negative Bacteria
Authors: Prieto-Montero Ruth , Tejón Maite , Albaya Andrea , Arbeloa Teresa , Chiara Jose Luis , L. Fanárraga Mónica , MARTINEZ-MARTINEZ VIRGINIA
Published: December 2023

Antimicrobial Photodynamic Therapy (aPDT) is an emerging strategy to fight against resistant pathogenic bacteria, which is considered a serious health problem. In this work, we described the functionalization of cellulose nanocrystals (CNC) with two photosensitizers (PS): one cationic and the other anionic, Rose Bengal (RB) and Toluidine Blue O (TBO), respectively, together with a specific target, gluconamide, as potential nanosystem for a PDT against Gram-negative bacteria such as Escherichia Coli (E. coli). The nanosystems loaded with the photosensitizers (PS@CNC) are chemically and photophysically characterized and tested in E. coli bacteria comparing their cyto- and phototoxicity with the PSs in solution. The resultant PS@CNC have reduced the inherent cytotoxicity of PSs in dark conditions maintaining their phototoxicity activity under green and red irradiation for RB@CNC and TBO@CNC, respectively. The presence of gluconamide as the target has improved the phototoxic of the nanosystem.
Novel dihydropteridinone derivatives as potent and selective inhibitors of the understudied human vaccinia-related kinase 1 (VRK1)
Authors: H. de Souza Gama Fernando , Dutra Luiz , Hawgood Michael , Vinícius dos Reis Caio , Serafim Ricardo , Ferreira Jr. Marcos , V. M. Teodoro Bruno , Takarada Jéssica , Santiago André , M. Almeida Vitor , Gileadi Carina , Zonzini Ramos Priscila , Salmazo Anita , Vasconcelos Stanley , Cunha Micael , Ballourdas Dimitrios-Ilias , Mueller Susanne , Knapp Stefan , Massirer Katlin , Elkins Jonathan , Gileadi Opher , Macarello Alessandra , Lemmens Bennie , R. W. Guimarães Cristiano , Azevedo Hatylas , Couñago Rafael
Published: December 2023

The human Vaccinia-Related Kinase 1 (VRK1) is highly expressed in various tumor types and plays important roles in cell proliferation and the maintenance of genome integrity. While prior genetic studies indicate that VRK1 inhibition offers therapeutic potential, especially in cancers deficient in VRK2 expression or DNA damage repair, the current lack of suitable VRK1 inhibitors hampers the validation of this kinase as a therapeutic target and the translation of these findings to the clinic. Here, we developed novel VRK1 inhibitors based on BI-D1870, a pteridinone inhibitor of RSK kinases. Our optimized VRK1 inhibitor displays improved kinome-wide selectivity, and effectively mimic cellular outcomes of VRK1 depletion. Notably, VRK1 inhibition triggered severe mitotic errors and genome instability in p53-deficient cells. Together, our findings highlight the potential of VRK1 inhibition in treating p53-deficient tumors and possibly enhancing the efficacy of existing cancer therapies that target DNA stability or cell division.
Tandem Manganese Catalysis for the Chemo-, Regio-, and Stereoselective Hydroboration of Terminal Alkynes: In Situ Precatalyst Activation as a Key to Enhanced Chemoselectivity
Authors: Duran Arroyo Victor , Arevalo Rebeca
Published: December 2023

The manganese(II) complex [Mn(iPrPNP)Cl2] (iPrPNP = bis(diisopropylphosphine)pyridyl)) was found to catalyze the stereo- and regioselective hydroboration of terminal alkynes employing HBPin (pinacolborane). In the absence of in situ activators, mixtures of alkynylboronate and E-alkenylboronate esters were formed, whereas when NaHBEt3 was employed as in situ activator, E-alkenylboronate esters were exclusively accessed. Mechanistic studies revealed a tan-dem C-H borylation / semihydrogenation as the pathway accounting for the formation of the products. Stoichiometric reactions hint toward reaction of a Mn-H active species with the terminal alkyne as the catalyst entry pathway to the cycle, whereas reaction with HBPin led to catalyst deactivation.
Controlling Aggregation-Induced Emission by Supramolecular Interactions and Colloidal Stability in Ionic Emitters for Light-Emitting Electrochemical Cells
Authors: Sanz-Velasco Alba , Amargos-Reyes Olivia , Kähäri Aya , Lipinski Sophia , Cavinato Luca , Costa Ruben , Kostiainen Mauri , Anaya-Plaza Eduardo
Published: December 2023

Chromophores face applicability limitations due to their natural tendency to aggregate, with a subsequent deactivation of their emission features. Hence, there has been a fast development of aggregation induced emission (AIE) emitters, in which non-radiative motional deactivation is inhibited. However, a fine control of their colloidal properties governing the emitting performance is fundamental for their application in thin film optoelectronics. In addition, ion-based lighting devices, such as light emitting electrochemical cells (LECs), requires the design ionic AIE emitter, whose structure allows i) an easy ion polarizability to assist charge injection and transport processes and ii) a reversible electrochemical behavior. To date, these fundamental questions have not been addressed yet. Herein, the hydrophilic/hydrophobic balance of a family of cationic tetraphenyl ethene (TPE) derivatives is finely tuned by chemical design., The hydrophilic yet repulsive effect of pyridinium-based cationic moieties is balanced with hydrophobic variables (long alkyl chains or counterion chemistry), leading to i) a control between monomeric/aggregate state ruling photoluminescence, ii) redox behavior, and iii) enhanced ion conductivity in thin films. This resulted in a LEC enhancement with the first ionic AIE emitters, reaching values of ca. 50 cd/m2 at 0.19 lm/W. Overall, this design rule will be key to advance ionic active species for optoelectronics.
The retaining Pse5Ac7Ac pseudaminyltransferase KpsS1 defines a new glycosyltransferase family (GTXXX)
Authors: Walklett Abigail , Flack Emily , Chidwick Harriet , Hatton Natasha , Keenan Tessa , Budhadev Darshita , Walton Julia , Thomas Gavin , Fascione Martin
Published: December 2023

Cell surface sugar 5,7-diacetyl pseudaminic acid (Pse5Ac7Ac) is a bacterial analogue of the ubiquitous sialic acid, Neu5Ac, and contributes to the virulence of a number of multidrug resistant bacteria, including ESKAPE pathogens Pseudomonas aeruginosa, and Acinetobacter baumannii. Despite its discovery in the surface glycans of bacteria over thirty years ago, to date no glycosyltransferase enzymes (GTs) dedicated to the synthesis of a pseudaminic acid glycosidic linkage have been unequivocally characterised in vitro. Herein we demonstrate that A. baumannii KpsS1 is a dedicated pseudaminyltransferase enzyme (PseT) which constructs a Pse5Ac7Ac-(2,6)-Glcp linkage, and proceeds with retention of anomeric configuration. We utilise this PseT activity in tandem with the biosynthetic enzymes required for CMP-Pse5Ac7Ac assembly, in a two-pot, seven enzyme synthesis of an -linked Pse5Ac7Ac glycoside. Due to its unique activity and protein sequence, we also assign KpsS1 as the prototypical member of a new GT family (GTXXX).