bluuebunny/crossref_metadata_2025 huggingface dataset:
La Tecnología en la Educación y Formación de los Servidores Públicos
Authors: Vicher García Diana
Published: December 2022

En este artículo se analizan las dos acepciones que sobre tecnología se pueden distinguir en los orígenes, desarrollo y evolución de la administración pública en términos de la formación de los servidores públicos: como forma de hacer (techné), y como instrumento (herramienta), cuya relación se puede rastrear desde el tercer milenio a.C., cuando surgen instituciones que tendrán como propósitola enseñanza de la administración pública que paralelamente, incorporan la tecnología para potenciar el trabajo administrativo.
A propósito de los debates públicos sobre la Evaluación Legislativa en países de Europa y América Latina
Authors: Ramírez Roldán Jose David
Published: December 2022

El presente artículo comprende a la legislación como una intervención pública más como parte de la acción estatal de un país. El propósito de este trabajo es reflexionar sobre los debates internacionales y las posibilidades institucionales existentes en algunos países de Europa y América Latina para realizar Evaluaciones Legislativas de manera formal, empero, se busca identificar el estado actual de este campo a raíz de los avances u obstáculos de su profesionalización.
Terapi Gangguan Tidur pada Anak Tk dengan Sleep Hygiene
Authors: Farasari Poppy , Widyawati Evita , Oktaviana Friska , Farida Farida , Yitno Yitno
Published: December 2022

Gangguan tidur merupakan kelainan pada pola tidur seseorang dimana akan menimbulkan penurunan kualitas tidur yang ber dampak pada kesehatan dan keselamatan penderitanya. Terapi non farmakologi gangguan tidur antara lain adalah melalui aktivitas sleep hygiene. Sleep hygiene merupakan teknik melatih perilaku dan lingkungan yang bertujuan untuk memberikan lingkungan dan kondisi yang kondusif untuk tidur. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh terapi sleep hygiene terhadap gangguan tidur pada anak Taman Kanak-Kanak  Alhidayah Desa Jombok Kecamatan Pule Kabupaten Trenggalek. Penelitian ini dilakukan pada tanggal 25 Maret sampai dengan tanggal 25 April 2022 dengan menggunakan metode Quasi Experiment Design dan menggunakan pendekatan one group Pre Test dan Post Test design. Populasi pada penelitian ini adalah anak usia sekolah (4-6 tahun) yang mengalami gangguan pada tidur di Taman Kanak-Kanak berjumlah 50 anak, sampel diambil menggunakan teknik purposive sampling berjumlah 33 responden. Variabel independentnya adalah terapi sleep hygiene, variabel dependentnya adalah gangguan tidur pada anak. Pengolahan data dengan editing, coding, scoring dan tabulating, dengan menggunakan analisa data uji Wilcoxon signed rank. Pada Hasil penelitian ini didapatkan jika sebelum dilakukan terapi sleep hygiene sebagian besar responden yaitu sebanyak 21 responden (63,6%) mengalami gangguan pada tidur berat dan sesudah sleep hygiene sebagian besar responden yaitu sebanyak 17 responden (51,5%) tidak mengalami gangguan pada tidur. Hasil dengan uji wilcoxon didapatkan bahwa P Value = 0,000 < 0,05. Dari hasil penelitian ini menunjukkan bahwa terdapat pengaruh terapi sleep hygiene terhadap gangguan tidur, hal ini terbukti jika terapi sleep hygiene mampu mengubah pola tidur pada anak menjadi lebih baik, sehingga hasil penelitian ini dapat dijadikan pedoman salah satu penatalaksanaan gangguan tidur pada anak menggunakan terapi sleep hygiene.
Pemanfaatan Data Rekam Medis dalam Menentukan Cluster Penyakit Melalui Data Mining di Rs Aisyiyah Siti Fatimah Tulangan Sidoarjo
Authors: Yudano Brema Arya , Indahyanti Uce , Nisak Umi Khoirun
Published: December 2022

Jumlah rekam medis yang masuk setiap hari mengalami penambahan jumlah data di rumah sakit Aisyiyah Siti Fatimah Tulangan Sidoarjo. Namun, data yang tersimpan terbatas menjadi tumpukan data yang belum tergali secara optimal dalam pemanfaatannya. Pemanfatan data yang belum optimal seharusnya dapat dimanfaatkan untuk menghasilkan informasi baru jika digali lebih dalam dengan metode data mining. Penelitian ini bertujuan melakukan clustering diagnosa penyakit berdasarkan data rekam medis menggunakan algoritma K-Means. Metode penelitian menggunakan deskriptif. Hasil proses clustering software RapidMiner dengan 5 cluster mendapatkan hasil C0 didominasi diagnosa I11.0, C1 didominasi diagnosa E11.8, C2 didominasi diagnosa A15.3, C3 didominasi diagnosa E05.9, C4 didominasi diagnosa E11.8. Uji validitas cluster menggunakan metode Davies Bouldin Index (DBI) dengan 5 cluster mendapatan nilai 0.469
Modernidad Sísmica
Authors: Quezada Espinoza David
Published: December 2022

Los escasos daños que el terremoto del 27 de febrero de 2010 ocasionó en la Unidad Vecinal Portales, introducen un nuevo interés en el estudio de su estructura sismorresistente, el comportamiento de los elementos y en cómo comparece el carácter telúrico en el diseño arquitectónico. Constatamos en sus bloques edificados una transformación de la modernidad europea y que, pese a las aparentes semejanzas formales y consonancia con los principios de ésta, parece sugerir una manera de diseñar propia anclada en el efecto del movimiento de las placas tectónicas. El diseño chileno responde a la sismicidad de nuestro territorio y los modernos pilotis europeos se transforman en un lenguaje estructural a base de muros. El muro desencadena una arquitectura propia – local – generada por los esfuerzos laterales que deben resistir los elementos que conforman los bloques de la villa. Bresciani, Valdés, Castillo y Huidobro capturan el espíritu de la época en su forma de proyectar al ejecutar el conjunto densificado separando áreas verdes y circulaciones. Pero, la condición sísmica aparece como factor principal. Luego, es posible postular el nacimiento de una tipología de vivienda moderna a partir de un método proyectual que considera al sismo como variable fundamental.
Orientaciones legales para desempeñar la ingenieria estructural
Authors: Santos Hernán
Published: December 2022

Los nuevos escenarios que caracterizan al siglo XXI se ven reflejados en una extensión creciente de las responsabilidades legales aplicables a la industria inmobiliaria. Sin embargo, sus profesionales siguen confiando en el éxito histórico de sus habilidades técnicas, eludiendo el hecho que esta evolución de la sociedad obliga a considerar también el desafío de un mayor deber de cuidado. En este contexto, este documento presenta la visión personal de un ingeniero civil y aficionado a las leyes, respecto de algunos alcances de esta nueva cultura de judicialización.
Relación entre los médicos y pacientes en un hospital público
Authors: Camargo Warner , Farias Diana
Published: December 2022

Este articulo tuvo de objetivo identificar las representaciones sociales de la relación médico-paciente en la visión de los pacientes en el Hospital General de Palmas Dr. Francisco Ayres, Palmas – Tocantins, Brasil. Para ello, se utilizaron las representaciones sociales en el contexto de la relación médico-paciente hospitalaria. El procedimiento metodológico utilizado fue una investigación de tipo descriptivo y transversal, con el fin de ampliar la comprensión de los objetivos propuestos, con enfoque mixto. A través de estos modelos metodológicos, reflexionamos que la comunicación enérgica entre médico y paciente como una situación clínica central, principalmente en el desenvolvimiento de una relación terapéutica de confianza. Los resultados permitieron analizar la actuación de estos profesionales a través de la visión de los pacientes, donde pudimos confirmar que las representaciones sociales de la figura médica para los pacientes en la institución hospitalaria están en desacuerdo con lo esperado, principalmente respecto a la atención médica, al tiempo ofrecido, la dedicación en el contexto pandémico y la accesibilidad. Comprenderse la necesidad de la comunicación de los pacientes con el médico, facilitando el asesoramiento adecuado, instrucciones terapéuticas y establecimiento de una relación afectiva.
Variación de la frecuencia cardiaca y saturación de oxígeno en las fases del acto quirúrgico durante la extracción de terceros molares
Authors: Huacasi Gaelord , Villca Orlando , Quispe-Cruz Henry , Rodríguez Jhony , Arocutipa Wilbert
Published: December 2022

El artículo tuvo por objetivo determinar la relación entre la variación frecuencia cardiaca y saturación de oxígeno de la hemoglobina durante las fases del acto quirúrgico en pacientes sometidos a extracción de terceros molares. Fue de tipo observacional, descriptiva, relacional, transversal y prospectiva. La muestra fue seleccionada por conveniencia de ambos géneros y estuvo conformada por 30 pacientes en una clínica odontológica. Se registró la pulsioximetría durante las 6 fases del acto quirúrgico. La recolección de los datos se hizo mediante una ficha, que fueron procesados con el software SPSS22. Se analizó los resultados mediante estadística descriptiva, prueba de Chi cuadrado de asociación y T de Student. Se halló que para la frecuencia cardiaca se presentó un valor mínimo en la fase post operatorio con 62.00 lpm, el máximo valor fue observado en la fase de intervención quirúrgica propiamente dicha con 104 lpm la media más alta fue también en esta fase con 91.10 ± 7.61. lpm y la media más baja fue durante el preoperatorio con 72.80 ± 5.08 lpm. Para la saturación de oxígeno arterial se presentó como valor mínimo 86.00 % SatO2, el valor máximo fue durante la fase de sutura con 94 % SaO2; la media o promedio fue ligeramente mayor en la fase pre operatoria 89.87 ± 1.61 %SaO2, y la mayor desviación estándar fue observada en la fase de intervención quirúrgica con una media de 89.33 ± 2.07. Para la frecuencia cardiaca en ambos géneros existe una relación estadística significativa (p=0.0001). Para la saturación de oxígeno en ambos géneros no existe relación estadística la probabilidad en femeninos (p=0.296) y masculinos (p=0.522) presentándose valores medios de saturación. Concluyendo que existe relación directa entre la frecuencia cardiaca y la fase del acto quirúrgico.
Production of growth factors by fibroblasts in the conditions of the wound process and under the exposure of a bacterial biofilm matrix
Authors: Yarets Yuliya I.
Published: December 2022

Aim to analyze the production of growth factors by fibroblasts in the wound process and under the influence of the bacterial biofilm matrix.
Material and methods. We assessed the levels of such growth factors as: VEGF, TGF-1, GM-CSF, FGF produced by granulation tissue fibroblasts of acute wound (AW) (group 1, n=9) and chronic wound (CW) (group 2, n=17). Skin fibroblasts (n=5) were used for reference. The primary cultures were obtained by the method of explants. The experimental biofilm matrix included S. aureus, E. faecalis, A. baumannii, P. aeruginosa, K. pneumoniae, P. mirabilis (5 of each species).
Results. The elevated levels of TGF-1 and VEGF, secreted by the primary cultures of fibroblasts, against of the absence of changes in the values of FGF and GM-CSF, are the criteria for the imbalance of growth factors characteristic of CW. The impact of the biofilm matrix P. aeruginosa, K. pneumoniae, A. baumannii, P. mirabilis on skin fibroblasts was accompanied by an increase in the production of VEGF and GM-CSF and a decrease in the synthesis of TGF-1 and FGF. In the experiments with S. aureus and E. faecalis, a similar direction of changes was recorded, but the degree of its severity was lower than for experiments with the gram-negative bacteria.
Conclusion. The obtained results have demonstrated various effects of the biofilm matrix on the production of growth factors by fibroblasts and updated the information on the pathogenesis of CW formation. The revealed imbalance in the synthesis of growth factors by fibroblasts in the granulation tissue of wounds with borderline lifetimes (2228 days) determines the need for tactical approaches in the treatment of CW.
ACCULTURATION OF TRADITIONAL AND ISLAMIC LAW IN THE PRACTICE OF INHERITANCE DISTRIBUTION OF THE MANDAILING TRIBE OF NORTH SUMATRA
Authors: Saniah Nur , Bastomi Ahmad
Published: December 2022

Acculturation of al-adat and Islamic law is a means to determine the extent to which Islamic law and local custom come into contact with the life practices of the Mandailing Tribe community of Islam without any contradictions. This research is empirical research with descriptive analysis. Research data were collected using observation and interview methods, then analyzed using content analysis methods. The results of this study indicate a synergism of the Mandailing tribal community, which adheres to a patrilineal kinship system to carry out Islamic law in parallel and local customs. The practice of sharing inheritance in the Mandailing tribal community is carried out traditionally by containing Islamic values. This practice is a realization of the philosophy of the Mandailing tribal community as "Ombar do adat dot ugama" and "The Customary Country of Obedience to Worship" as a forum to unite the Islamic legal and the customary law system. The acculturation of Islamic law and customary law in sharing inheritance in the Mandailing community shows that Islamic law can be dialogued with the customs that live in the community while still realizing the values of justice and benefit. Inheritance practice that dialogues Islamic law and the customary law of the Mandailing tribe in the inheritance distribution process, making daughters as heirs, presenting religious and traditional leaders during the inheritance distribution process, while maintaining undivided assets in the form of heirloom houses and objects for the son (youngest).
ANALISIS SWOT MATRIKS IFE DAN EFE UNTUK MENENTUKAN STRATEGI PENGEMBANGAN PASAR PADA JASA CV ZIGZAG LASERWORK SEMARANG
Authors: Hendarsih Ida
Published: December 2022

ABSTRAKPengembangan pasar bagi suatu usaha bisnis kecil, sedang maupun besar tetap membutuhkan suatu Analisa khusus dibidang pemasaran agar usaha atau bisnis dijalan dapt bertahan dalam jangka lama atau Panjang. Hal ini juga berlaku untuk usaha jasa laser cutting ZigZag Semarang untuk melakukan evaluasi menilai terhadap kegiatan bisnisnya sehingga dapat mengambil keputusan strategi pasar apa yang sebaiknya dilakukan. Analisa yang dipakai dengan menggunakan analisa metode SWOT untuk dapat menentukan alternatif strategi mana yang harus dilakukan perusahaan dari hasil perhitungan faktor internal dan pengaruh faktor eksternal perusahaan, agar dapat meningkatkan pelayanan jasa grafir laser cutting. Penilaian Analisa SWOT dengan cara mendeskripsikan Internal Factor Evaluation (IFE) dan Eksternal Factor Evaluation (EFE) sehingga perusahaan dapat mempertahankan kualitas pelayanan produk untuk menarik konsumen, menjalin kerjasama, mempercepat pelayanan pengiriman bahan baku dan meningkatkan kemampuan manajemen. Hasil nilai perhitungan IFE adalah nilai tertinggi nilai Kekuatan (Strength) 0,394 adalah suasana ruangan nyaman, Kelemahan utama Hubungan baik dan loyalitas pelanggan belum terbina secara baik dengan hasil nilai 0,269 Hasil perhitungan EFE dipeluang (opportunity) memperluas pangsa pasar sangat besar dengan nilai 0,471sedangkan ancaman yang mempunyai nilai 0,123 Pengiriman bahan baku lama, maka harus mencari lagi jasa kurir pengiriman tepat waktu.Kata Kunci: Analisis SWOT IFE&EFE, Stategi Pengembangan PasarABSTRACTMarket development for a small, medium or large business still requires a special analysis in the field of marketing so that the business or business can survive in the long or long term. This also applies to the ZigZag Semarang laser cutting service business to evaluate its business activities so that it can make decisions on what market strategy should be implemented. The analysis used is using the SWOT analysis method to be able to determine which alternative strategies the company should carry out from the results of calculating internal factors and the influence of external factors of the company, in order to improve laser cutting engraving services. SWOT Analysis Assessment by describing Internal Factor Evaluation (IFE) and External Factor Evaluation (EFE) so that companies can maintain product service quality to attract consumers, establish cooperation, accelerate raw material delivery services and improve management capabilities. The result of the IFE calculation value is the highest value of Strength (Strength) 0.394 is the comfortable atmosphere of the room. The main weakness is that good relations and customer loyalty have not been well developed with a value of 0.269. which has a value of 0.123 Delivery of old raw materials, then you have to look for a courier service for delivery on time.Keywords: IFE&EFE SWOT Analysis, Market Development Strategy
Advocacy e organizações da sociedade civil
Authors: MONTEIRO Lorena Madruga , HORA FILHO Flávio Kummer , MOURA Joana Tereza Vaz de
Published: December 2022

Atualmente observa-se um movimento no sentido do alargamento da representação política, não mais limitado por sanções, accountability e autorizações públicas, como na representação política eleitoral típica das democracias liberais (LAVALLE, HOUTZAGER e CASTELO, 2006), mas que busca incidir e pressionar a agenda pública através de redes e coalizões de incidência política (Advocacy).  Para compreender a emergência da utilização de estratégias de advocacy pelas organizações da sociedade civil analisou-se, enquanto uma iniciativa de advocacy em rede, o Pacto pela Democracia. Os dados foram obtidos através dos sites eletrônicos de 77 organizações da coalizão de incidência política Pacto pela Democracia que, adotam, dentre outros repertórios de ação coletiva, o advocacy para promover sua causa na agenda pública. A par das caraterísticas das organizações buscou-se analisar os valores que defendem com o objetivo de apresentar um quadro analítico geral das causas de advocacy defendidas por essas organizações e suas aproximações. Para isso utilizou o recurso da nuvem de palavras construídas a partir do software Iramuteq. Conclui-se que a incidência política concretizada a partir dessas organizações apresentam-se como uma ressignificação e ampliação do fazer político e de defesa dos direitos humanos.
ENDOPARASITES OF VIETNAMESE BELLIED PIGS IN THE PASTURE GROWING SYSTEM IN FARMS OF THE ODESA REGION
Authors: Bogach М. , Bohach О.
Published: December 2022

The article provides data on the spread of endoparasitoses in vietnamese bellied pigs in the pasture growing system in the farms of the Odesa region. Pigs can have numerous intestinal parasites, most often protozoa and nematodes. Although the course of such parasitic infections is usually subclinical, clinical manifestations may occasionally occur, especially in growing pigs. The study of the structure and functioning of parasitic systems is extremely important. The obtained data on gastrointestinal parasites in pigs can help in the development of effective and sustainable measures for the prevention of pig diseases.

The aim of the work was to monitor endoparasitoses in vietnamese bellied pigs in the pasture growing system, depending on age, in the farms of the Odesa region.

A total of 475 samples of feces of vietnamese bellied pigs from 6 private farms of Odesa region were studied. Fecal samples were collected from suckling piglets and weanling piglets (<4 months), young (4‒8 months) and adults (>8 months) of both sexes.

It was established that the total infestation with protozoa in piglets < 4 months. age was 86.7 %, in growing pigs (4-8 months) ‒ 28.9 %, and in adults ‒ 18.7 %, helminthes infestation was 13.3 %, 71.1% and 81.3% in accordance. Piglets < 4 months. age, Isospora suis (28.3 %) and Eimeria suis (18.6 %) were most infested, while Strongyloides sp. (2.7 %).

Ascaris suum (33.4 %) and Trichuris suis (24.6 %) had the highest lesion extent in growing pigs (4‒8 months), and the lowest among protozoans was Isospora suis and Blastocystis sp. (2.9 %). In adult pigs, the highest infestation of Ascaris suum (34.4 %) and Trichuris suis (31.2 %) was recorded, while isosporosis and cryptosporidiosis were not recorded.
EFFECT OF FEEDING DIFFERENT DOSES OF TRITICAL GRAIN ON THE DEVELOPMENT OF RABBITS INTERNAL ORGANS
Authors: Hryniv M. V. , Darmohray L. M. , Fedak N. M.
Published: December 2022

The results of the study of the influence of Poliske 7 triticale grain for its addition into the standard granulated compound feed to replace cereal ingredients (barley and oats) at the rate of 100; 50; 25 and 12.5%, respectively are highlighted, in the I, II, III and IV research groups on the massometric indicators of the internal organs of young rabbits of the termon breed with the intensive technology of growing them for meat. It was established that feeding triticale grain as a part of a complete ration granulated compound feed in the period from 50 to 100 days of age to experimental groups of rabbits led to an improvement in the relative indicators of internal organs, compared to the control group.

It was noted that the addition of triticale grain into the compound feed in the amount of 50 and 12.5% led to changes in the weight of internal organs, the weight of the stomach and the length of the small and large intestine sections compared to the control group, which may indicate a positive effect of triticale grain on young rabbits.

The mass of the entire alimentary canal was 3.6% greater in the animals of the II experimental group compared to the control. The use of experimental compound feed in rations contributed to an increase in the weight of the empty stomach by 14.7% in rabbits of III and 11.2% of IV experimental groups, the weight of the small intestine with chyme in animals of II, III and IV experimental groups - by 19.6; 10.7 and 3.9% compared to the control, fat mass – by 7.4, respectively; 3.6 and 1.9%.

Тriticale grain in the amount of 50 and 12.5% of the weight of the grain group contributed to the tendency to increase the edible body parts of young rabbits compared to the control. The weight of the cooled carcass of rabbits of all experimental groups increased by 9.6; 10.2; 3.4 and 14.7%. It should be noted that the mass of pulp in the carcasses of animals of the II and IV groups was higher by 11.1 and 1.5%, and the mass of internal fat was lower by 6.3 and 1.6% compared to the analogues, which indicates a positive the effect of feeding triticale grain as part of granulated compound feed.

There was a tendency towards an increase in the weight ratio of the liver, lungs and heart of rabbits of all experimental groups compared to the control.
THE TENDENCY OF TRANSGENIC PLANTS SPREAD IN 2019-2021
Authors: Kuchnir G. V. , Levitskyj T. R. , Ryvak G. P. , Fedor G. Y. , Kurylas L. V. , Senyshyna T. Ye.
Published: December 2022

The achievement of modern biotechnology, in particular genetic engineering in crop production, provides not only the possibility of increasing production, but also more efficient use of natural resources and reduces the negative impact on the environment. Recent publications indicate the widespread distribution of genetically modified (GM) agricultural crops in the world that are currently in commercial use, research and development. All over the world, the most cultivated GM crops are cotton, soybeans, corn, and rapeseed, and the area under these biotechnological crops continues to grow every year. However, the analysis of publicly available sources of information revealed the risks of negative effects of GMOs on human and animal bodies, as well as on the environment and biodiversity.

The article analyzes the results of research on the presence of GM ingredients in plant raw materials, processing products, and feed for productive and non-productive animals for the period 2019-2021. The study was conducted by the polymerase chain reaction method in real time (PCR-RF), according to DSTU ISO 21569:2008 (ISO 21569:2005, IDT), and DSTU ISO 21571:2008 (ISO 21571:2005, IDT). In the studied samples were detected target sequences of the promoter p35S CaMV (cauliflower mosaic virus), promoter p34S FMV, terminator NOS (T-NOS) T1 of the Agrobacterium tumefaciens plasmid, genes Pat, EPSPS, Cry 3A.

Transgenic plants are present in circulation in the agricultural market of Ukraine, and the area under their crops is increasing.

The largest number of GM plants was found in samples of rapeseed, soybeans, and feed for productive and non-productive animals. There was a tendency for an increase in the number of transgenic plants in tested samples. During rapeseed research in 2019, the number of positive samples was 6.5%, in 2020 – 7.4%, and in 2021 – 14.3%. When studying soybeans in 2019, the number of positive samples was 6.7%, in 2020 – 16.7%, and in 2021 – 18.2%.

GM ingredients were also found in feed for productive and non-productive animals. In 2020 16.7% of compound feed for poultry were positive, while in 2021 there were no samples for research.

As for feeds for non-productive animals, during 2019–2020 there were no detected positive samples, while in 2021 the number of positive samples was 12%.
REASONS FOR INCONSISTENCY IN THE QUALITY OF RODENTICIDES (PROCESSED GRAIN, PASTE) WITH BROMАDIALON AND BRODIFACOUM
Authors: Ostapiv R. D. , Humenyuk S. L. , Samarska L.K. , Berezyuk M. I.
Published: December 2022

Rodenticides are a class of biocides whose primary purpose is to kill rodents. Rodenticides are divided by the mechanism of action into acute and chronic. In Ukraine, most of the registered drugs are of chronic action, as they are more effective against rodents. Bromаdiolone and brodifacoum are the main active substances of rodenticides with a chronic effect. Since these substances absorb well in the ultraviolet spectrum and their concentration in the preparation is low -0.005%, the quality control of chronic rodenticides is carried out, in most cases, by high-performance liquid chromatography. The purpose of the work was to analyze the quantitative content of active substances in solutions of bromаdiolone and brodifacoum and in ready-made rodenticides (grain, paste) during 2012–2022 and to establish possible reasons for non-compliance with the specification.

The study was conducted using a Dionex Ultimate 3000 chromatograph and validated methods for determining the quantitative content of bromаdiolone and brodifacoum in rodenticides. Thirty-six samples of ready-made rodenticides and solutions for their preparation were analyzed. It was found that one third of the examined samples did not meet the requirements of regulatory documentation. Of the 22 ready-made baits for the destruction of rodents, 5 did not meet the specification. Since the active substance in the preparation itself is a little -0.005%, it can be assumed that these results are related to the violation of technological regulations in the production process. However, we found that out of 14 analyzed solutions for the production of ready-made rodenticides, in the form of processed grains or briquettes, 7 do not meet the requirements of the specification. This may be due to errors in the preparation of bromаdiolone and brodifacoum solutions, or to substances that do not correspond to what is stated in the quality certificate. Therefore, it is very important for manufacturing companies to carry out incoming control of raw materials, both substances and solutions for the preparation of ready-made rodenticides.
DEVELOPMENT AND VALIDATION OF HPLC-METHOD DETERMINING QUANTITATIVE CONTENT OF CEFTIOFUR HYDROCHLORIDE IN SUSPENSIONS FOR INJECTION
Authors: Ostapiv R. D. , Tkachenko V. І. , Chipak S. Yu.
Published: December 2022

Ceftiofur is a third-generation cephalosporin used in veterinary medicine to treat infections caused by gram-negative and gram-positive bacteria. It is most often used in the form of suspensions for injections based on a lipid matrix, since the active substance is poorly soluble in water. The analysis of such a drug by direct spectrophotometry is difficult due to the components of the matrix, therefore it is proposed to develop a high-performance liquid chromatography method with UV detection.

The aim of the work was to develop a method of identification and quantitative determination of ceftiofur hydrochloride in suspensions for injections. The method was developed and validated according to the indicators of selectivity, robustness, linearity and suitability parameters of the chromatographic system. Suspension for injections containing ceftiofur 50 mg/ml was used as a sample-object for method development. The standard sample and the test sample were dissolved in the mobile phase to a concentration of 50 μg/ml. The total uncertainty of the analysis was 1.62%, which is within the limits recommended in DFU 2.0. The samples were separated on a Dionex Ultimate 3000 chromatograph equipped with a Kinetex C18-XB 150×4.6, 5 μm chromatographic column. The mobile phase was a mixture of acetonitrile and 0.05 M ammonium acetate, 0.01 M tetrabutylammonium bromide with a pH of 6.8, titrated with acetic acid, in a volume ratio of 3:7. Ceftiofur hydrochloride was detected spectrophotometrically at a wavelength of 290 nm.

Under the above conditions, it was possible to completely separate ceftiofur (retention time of the chromatographic peak – 4.4 min) and other components of the studied drug. At the same time, the suitability parameters of the chromatographic system did not exceed the limits specified in the recommendations of the USA Food and Drug Association. For the ceftiofur hydrochloride peak, the efficiency of the chromatographic system was 13,900 theoretical plates. The relative standard deviation (RSD) for the peak areas of the active substance was ±0.11 %, and the peak separation coefficient (RS) of ceftiofur hydrochloride from other components of the drug was 17.3. The symmetry coefficient of the peak was 1.02. The calibration curves were linear in the recommended DFU 2.0 range (80–120% of the nominal concentration of the corresponding active substance). The coefficient of linearity (R2) for the peak area of ceftiofur hydrochloride was 0.9992.
STUDY OF ACUTE DERMAL TOXICITY OF SODIUM-CONTAINING DRUGS
Authors: Patereha I. , Ostapiyk A. , Protsyk Ya. , Pyatnychko O. , Kushnir V.
Published: December 2022

To date, special attention should be paid to drugs that have antimicrobial, anti-inflammatory and wound-healing effects, one of which is sodium-containing drugs.

The article presents the results of experimental studies to study the acute toxicity of sodium-containing drugs: glycetinate 2 %, its analogues – ovocid 2 %, ovocid 3 %, potassium-sodium 1.5% (Na/K 1.5 %). The study of acute toxicity of drugs was carried out by applying drugs to the skin of animals. The experiment used white rats weighing 250-270 g. 4 groups of rats with 3 animals in each were formed: rats of group I on the skin was applied ovocid 3 %, group 2 - Nа/К 1,5 %, 3rd group - ovocid 2 %, and the 4th group of rats (control) was applied glycetinate 2 %. The animals were subjected to clinical observations, assessing their general condition and skin reaction. The effect of drugs on morphological and biochemical parameters of blood of rats was studied.

The studied drugs did not cause visible disorders of physiological functions, the appearance of clinical signs of intoxication. There were no significant clinical signs of inflammation or irritation (erythema, edema and cracks) on the skin of the animals, but there was a slight redness at the application site, which later disappeared.

The studied sodium-containing preparations (ovocid 3 %, Nа/К 1,5 %, ovocid 2 %, glycetinate 2 %) under the conditions of a single application of the preparation to the skin of animals did not cause the death of animals, which allows us to classify these preparations as low-toxic substances.
COMPARATIVE ASSESSMENT OF COMPLEX DRUGS BASED ON MOXIDECTIN AND PRAZIQUANTEL FOR DOG ENDOPARASITIC INVASIONS
Authors: Tishyn O. L. , Yuskiv I. D. , Yuskiv L. L. , Perih Zh. M.
Published: December 2022

The article presents data on the effectiveness of the new domestic complex antiparasitic drug «Moxistop for dogs» in comparison with the reference drug «Vormazol for dogs spot-on» that used for the treatment and prevention of endoparasitic infestations in dogs of different breeds, ages and sexes.

According to the results of parasitological studies, the animals of experimental and control groups were found to be spontaneously infected with endoparasites, the causative agents of nematodes: Toxocara canis with an intensity of invasion (II) from 210 to 250 eggs in one gram of feces, Ancylostoma caninum – from 52 to 80, Trichuris vulpis – from 58 to 85, respectively, and the cestode pathogen Dipylidium caninum – from 20 to 46 cocoons in one gram of feces. Nematodes and cestodosis in dogs were manifested clinically by: deterioration of appetite, depression, paleness of mucous membranes, and in some animals, vomiting and mild diarrhea (unformed feces).

Before 7th day and during next 7th-14th day after deworming, helminthocoprological studies were carried out with the establishment of indices of parasitological damage and determination of the extensive effectiveness and intensive effectiveness of the drugs.

Based on the obtained results, it was found that for a spontaneous toxocarosis infestation of dogs on the 7th and 14th day after deworming, the intensity effectiveness (IE) of the experimental drug «Moxistop for dogs» was 96.0 and 98.3%, and the intensity effectiveness of the reference drug «Vormazol for dogs spot-on» – 92.2 and 95.1%, respectively. At the same time, the extensive effectiveness (EE) of both drugs for 7 and 14 days after deworming was 85.7%.

Helminthological studies showed that for spontaneous hookworm infestation in dogs on 7th and 14th days after the use of the experimental drug and the reference drug in the recommended doses, the intensive and extensive effectiveness of the drugs was 100% in the experimental and control groups of animals.

In the case of spontaneous trichuria infestation, it was found that on the 7th and 14th day after deworming, the intensity of the experimental drug was 91.7 and 93.1%, and the intensity of the reference drug was 92.8 and 94.2%, respectively.

At the same time, it was found that for spontaneous dipilidiosis infestation of dogs, the intensity of the experimental drug «Moxistop for dogs» on the 7th day after deworming was 95.1% and on the 14th day – 96.9%, and the intensity of the reference drug «Vormazol for dogs spot-on» on the 7th and 14th day after deworming was 92.9 and 95.8%, respectively.

Field tests have shown that the research drugs are convenient to use, well tolerated by animals regardless of age, body weight and breed, and do not have a toxic effect on the animal's body when they are used once by the spot-on method in the manufacturer's recommended doses.
Al Lathif Islamic School Principal Performance Analysis In Balanced Scorecard Perspective
Authors: Tubilah Noor Sri
Published: December 2022

This study aims to analyze and assess the performance of principals who have implemented school-based management (SBM). An alternative management system tool to measure the work efficiency of the institution in measuring the performance of Al Lathif Islamic School in the city of Bandung using the Balanced scorecard model. A balanced scorecard is a management tool that translates the vision, mission, and organizational strategy of the Al lathif Islamic School into a set of four perspectives, namely the financial, customer, and internal business processes, as well as learning and growth perspectives. This study uses a quantitative approach with descriptive analysis. Primary data in the form of a questionnaire is used to measure the performance of the financial perspective and the perspective of learning and growth, while the measurement of the performance of the financial perspective and internal business process perspective uses secondary data. Sources of data were obtained from Educators, Education Personnel, Students, and Parents, EDS Documents, The Education Unit Accreditation Instrument (2021), Principal's Annual Work Assessment, School Financial Accountability Reports, and School Alumni Documents. The results showed that the performance of Al Lathif Islamic International School was in the very good category. Based on the financial perspective, obtaining good performance, namely meeting the economic requirements, effectiveness, and efficiency. Based on the perspective of the customer get a very good value by applying five dimensions (tangibility, reliability, responsiveness, assurance, empathy). Based on the internal business process perspective, the measurement results can be shown from the innovation aspect, operation aspect, and alumni service that has shown very good value results. Based on the learning and growth perspective, four indicators, namely the range of employee satisfaction, training, employee loyalty, and employee performance productivity are in the very good category
Mouth Treatment with The Incidence of Nau, Vogting In Breast Cancer Patients Undergoing Chemotherapy
Authors: Purbasari Dwiyanti , Syaripudin Ahmad , Susan Yanti
Published: December 2022

This study was to determine the relationship between oral care and the incidence of nausea and vomiting in breast cancer patients undergoing chemotherapy. This research method uses descriptive correlation by using a cross sectional approach. The sample of this study was breast cancer patients who underwent chemotherapy as many as 34 respondents using accidental sampling technique. The results of the univariate analysis of this study with oral care in the poor category as many as 29 respondents (82.9%) and nausea and vomiting in the poor category as many as 27 respondents (77.1%) in breast cancer patients undergoing chemotherapy. The results of this study found a relationship between oral care and nausea and vomiting in breast cancer patients undergoing chemotherapy with a value (p = 0.000 < = 0.05). In conclusion, the treatment is able to monitor the management of nausea and vomiting due to chemotherapy, the patient's response before, during and after chemotherapy, as well as assessing the effectiveness of oral care actions carried out by patients and their families
The Effect of Career Development and Training On Employee Performance With Compensation As An Intervening Variable At PT. Nagari Bank
Authors: Andaryansu Prim , Zefriyenni Zefriyenni , Lusiana Lusiana
Published: December 2022

This study aims to determine how big the influence of Career Development and Training on Employee Performance through Compensation as an Intervening Variable at PT. Nagar Bank. The method used is Structural Equation Modeling (SEM) with Partial Least Square (PLS) 3.0, with a total of 310 respondents. The results of data analysis concluded, there was a significant effect of Career Development variables on Compensation. There is a significant effect of the Training variable on the Compensation variable. There is no significant effect of Career Development variable on Employee Performance. There is a significant effect of the training variable on employee performance. There is a significant effect of the compensation variable on the Employee Performance variable. The Compensation variable mediates the relationship between the Career Development variable and the Employee Performance variable. The compensation variable does not mediate the relationship between the training variable and the employee performance variable
Pengenalan PLTS Kepada Pelajar Untuk Menumbuhkan Minat Terhadap Pengembangan Energi Terbarukan
Authors: Tunggal Prasetiyo Dani Hari , Baihaqi Mas Ahmad , Supraptiningsih Linda Kurnia , Wahyudi Djoko , Muhammad Alief , Fathuddin Noor Muhammad , Yulyawan Eva Kurnia
Published: December 2022

Technological developments and increasing population have created various problems, one of which is the energy sector. Indonesia has considerable potential to develop and exploit the potential of sunlight which can be converted into electrical energy. However, these efforts cannot run well if human resources (HR) do not understand the working system of solar power plants (PLTS). Therefore, efforts are needed to introduce and explore the potential of existing human resources. The target object of community service activities is carried out to junior high school students. PLTS is an interesting technology to convey to teenagers. Besides being able to arouse curiosity about PLTS, teenagers can also provide innovations in PLTS technology. Participants were enthusiastic when participating in the event and understood various types of renewable energy and renewable energy sources and understood the working system of solar panels.
IMMUNOTHERAPY OF GENODERMATOSES
Authors: V.L Dr.Premika sri , Muthukumar Dr.R.Sathish , A.H Dr.Harini priya , C Dr.Sreeja
Published: December 2022

Heterogenous group of incapacitating disorders affecting the cutaneous regions constitutes the genodermatoses. Oral Genodermatous conditions are inbred cutaneous disorderliness unveiling oral expressions. Tongue, palate, gingiva, salivary gland and alveolar dentition represents the common site. The specializing factor is that at times it might be the starring sign of this condition. Lack of awareness about this condition results in extensive dilemma to treat this condition. The current management criteria are also fictional for this particular disorders. Novel approach consists of repurposing drugs, and have been examined for other pathologies. Nevertheless, recent expertise stays furthermore contributing novel innovative gears, which aids to interpose the etiology of genodermatoses besides therefore both refurbish the unnatural gene or genomic artefact. The aim of dental intervention is to re-establish dental health. Further limiting factors and disputes which includes effective drug delivery and targeted therapy are discussed, emphasized in immunotherapy of genodermatosis.
ПРОБЛЕМЫ И СТРАТЕГИЧЕСКИЕ ЦЕЛИ ГОСУДАРСТВЕННОГО РЕГУЛИРОВАНИЯ РАЗВИТИЯ РЕГИОНОВ В РФ
Authors: Чажаев М.И. , Чажаева М.М.
Published: December 2022

Настоящее исследование посвящено концептуальным подходам к государственному регулированию социально-экономического развития на внутрирегиональном уровне. Региональная политика выравнивания себя исчерпала. Осмысление этих проблем происходит в последние годы и российским научным сообществом, и органами власти. В этой связи перед экономической наукой стоит задача обоснования теоретических подходов и методологических положений к разработке новой стратегии социально-экономического развития.
КРЕАТИВНОЕ УПРАВЛЕНИЕ КАК ФАКТОР СОЦИАЛЬНО-ЭКОНОМИЧЕСКОГО РАЗВИТИЯ
Authors: Ахмаров А.В. , Ахмарова Т.В.
Published: December 2022

Работа посвящена изучению креативного менеджмента как перспективного инструмента развития эффективности социально-экономических систем в рамках современной рыночной экономики. Особое внимание уделено сравнительному анализу положительных сторон реализации подходов креативного управления в рамках отечественной социально-экономической инфраструктуры, а также ключевых преимуществ концепции креативного мышления перед остальными методиками управления в рамках совершенствования профессионального потенциала управленческих кадров.
НЕОБХОДИМОСТЬ ОЦЕНКИ ЭФФЕКТИВНОСТИ ДЕЯТЕЛЬНОСТИ ОРГАНОВ МЕСТНОГО САМОУПРАВЛЕНИЯ ДЛЯ РЕГИОНАЛЬНОГО РАЗВИТИЯ
Authors: Иванова Е.А. , Довлетмурзаева М.А.
Published: December 2022

Статья посвящена исследованию проблем оценки эффективности деятельности органов местного самоуправления в Российской Федерации. Сложно представить гражданское общество, в котором нет местного самоуправления. Именно в силу этого современное государство развивает свои демократические принципы, связанные с управлением. Для комфортной и благоприятной жизнедеятельности гражданам нужен отлаженный межхозяйственный механизм взаимодействия. Муниципальное управление занимается решением вопросов местного назначения, которые касаются только местных жителей.
ПРИОРИТЕТЫ ЭФФЕКТИВНОСТИ И РЕЗУЛЬТАТИВНОСТИ МЕСТНОГО САМОУПРАВЛЕНИЯ
Authors: Хадуева Я.А. , Джабраилова Л.Х. , Джамалханова А.Х.
Published: December 2022

По вопросам результативности функционирования органов государственной и местной власти, роли местного самоуправления в современном Российском государстве, территориальной организации местного самоуправления ведется много дискуссий, опубликовано множество материалов. Помимо всего прочего, внимания заслуживает и другой фактор результативного функционирования органа управления муниципалитетом. В данном случае речь идет об организационной структуре. Управление местным образованием во многом зависит именно от нее. В статье рассматривается эффективное управление муниципалитетами, формирование стратегии муниципальной администрации, цели.
КАДРОВОЕ ОБЕСПЕЧЕНИE МУНИЦИПАЛЬНОЙ СЛУЖБЫ
Authors: Эльбиева Л.Р. , Тарамова Б.Ш.
Published: December 2022

Важнейшее место сейчас занимает реформа местного самоуправления, но модернизация функционирования местного самоуправления, к сожалению, невозможна без создания эффективного механизма управления развитием его кадрового обеспечения. Муниципальные служащие в настоящее время представляют собой особую социально–профессиональную группу и основной корпус кадрового состава органов местного самоуправления. Одной из целей профессиональной деятельности муниципальных служащих является обеспечение и организация благоприятных условий существования муниципального образования. Осуществляемая деятельность муниципальных служащих в первую очередь зависит от компетентности муниципальных служащих, их профессионализма, образованности, общей культуры и гражданской ответственности.
НАУЧНЫЕ ПОДХОДЫ К ОПРЕДЕЛЕНИЮ ФИНАНСОВЫХ РЕСУРСОВ КОМПАНИИ
Authors: Воронина И.И.
Published: December 2022

Тема данной статьи подробно освещает общее понятие финансовых ресурсов компании, а также существующие подходы по оценке эффективности их использования. Целью работы выступает выявление отдельных подходов к определению понятия и сущности финансовых ресурсов. В статье было рассмотрено определение «финансовые ресурсы» с позиции ряда отечественных авторов, таких как: Рудченко И.В., Казачок И.А., Леос А.Ю., Коваль И.С., Куличенко Ю.Л., Райзберг Б.А., Золотогоров В.Г., Бланк И.А. В ходе проведенной работы было установлено, что позиция И.А. Бланка наиболее емко и рационально характеризует данный термин. Также, в статье были рассмотрены существующие подходы по оценке эффективности финансовых ресурсов и их использования. Результатом данной работы является исследование основных принципов управления финансовыми ресурсами и их источниками в организации, а также рассмотрение различных научных взглядов на понятие финансовых ресурсов. По итогам исследования темы научной статьи были сделаны выводы о важности финансовых ресурсов для организации. Финансовые ресурсы играют особую роль в любой компании, потому что являются единственным видом ресурсов, превращающихся в различные другие виды ресурсов, таких как персонал, технологии, сырье и здания. Все это свидетельствует об их универсальности, возможности поддержки общего благополучия организации, ее платежеспособности и финансовой устойчивости.
РАСЧЕТЫ С ПЕРСОНАЛОМ ПО ОПЛАТЕ ТРУДА В БУХГАЛТЕРСКОМ УЧЕТЕ
Authors: Джумаева Я.М.-Х. , Абдулазизова Э.
Published: December 2022

В данной статье актуальность темы исследования обусловлена тем, что одной из основных статей расходов бюджетных организаций является заработная плата сотрудников; формирование и использование платежных ведомостей необходимо систематически контролировать; средства, используемые для оплаты труда, должны распределяться разумно, а средняя заработная плата работников должна равной прожиточному минимуму.
В соответствии с законодательством о структуре бюджета и бюджетном порядке бухгалтерский учет в бюджетной организации имеет специфические особенности. Эти функции включают организацию бухгалтерского учета в рамках статей бюджетной классификации; распределение кассовых и фактических расходов в бухгалтерском учете; ведомственные характеристики институционального учета государственного сектора.