bluuebunny/crossref_metadata_2025 huggingface dataset:
Ex vivo expanded allogeneic natural killer cells have potent cytolytic activity against cancer cells through different receptor-ligand interactions
Authors: Jung Daun , Baek Young Seok , Lee In Jee , Kim Ki Yeon , Jang Heejoo , Hwang Sohyun , Jung Jieun , Moon Yong-wha , Park Kyung-Soon , Choi Yong-Soo , An Hee Jung
Published: October 2021

Background

Recently, allogeneic natural killer (NK) cells have gained considerable attention as promising immunotherapeutic tools due to their unique biological functions and characteristics. Although many NK expansion strategies have been reported previously, a deeper understanding of cryopreserved allogeneic NK cells is needed for specific therapeutic approaches.

Methods

We isolated CD3−CD56+primary natural killer (pNK) cells from healthy donors and expanded them ex vivo using a GMP-compliant method without any feeder to generate large volumes of therapeutic pNK cells and cryopreserved stocks. After validation for high purity and activating phenotypes, we performed RNA sequencing of the expanded and cryopreserved pNK cells. The pNK cells were used against various cancer cell lines in 7-AAD/CFSE cytotoxicity assay. For in vivo efficacy study, NSG mice bearing subcutaneous cisplatin-resistant A2780cis xenografts were treated with our pNK cells or cisplatin. Antitumor efficacy was assessed by measuring tumor volume and weight.

Results

Compared to the pNK cells before expansion, pNK cells after expansion showed 2855 upregulated genes, including genes related to NK cell activation, cytotoxicity, chemokines, anti-apoptosis, and proliferation. Additionally, the pNK cells showed potent cytolytic activity against various cancer cell lines. Interestingly, our activated pNK cells showed a marked increase in NKp44 (1064-fold), CD40L (12,018-fold), and CCR5 (49-fold), and did not express the programmed cell death protein 1(PD-1). We also demonstrated the in vitro and in vivo efficacies of pNK cells against cisplatin-resistant A2780cis ovarian cancer cells having a high programmed death-ligand 1(PD-L1) and low HLA-C expression.

Conclusions

Taken together, our study provides the first comprehensive genome wide analysis of ex vivo-expanded cryopreserved pNK cells. It also indicates the potential use of expanded and cryopreserved pNK cells as a highly promising immunotherapy for anti-cancer drug resistant patients.
The clinical and cost-effectiveness of a self-management intervention for patients with persistent depressive disorder and their partners/caregivers: study protocol of a multicenter pragmatic randomized controlled trial
Authors: Solis Ericka C. , Carlier Ingrid V. E. , van der Wee Nic J. A. , van Hemert Albert M.
Published: October 2021

Background

After regular treatment, patients with persistent depressive disorder (PDD) may remain in specialized psychiatric outpatient care without achieving remission. Lacking other options, these patients often receive long-term, non-protocolized care as usual (CAU) that does not involve the partner/caregiver of the patient. Although the revised depression treatment guidelines suggest focusing on psychiatric rehabilitation and self-management as the next treatment step for PDD, an evidence-based cost-effective self-management protocol for PDD is lacking. This study investigates the “Patient and Partner Education Program for All Chronic Illnesses” (PPEP4All) as a brief self-management protocol that could lead to lower costs, higher quality of life, and less disease burden in PDD patients and their partners/caregivers.

Methods

Presented is the rationale and methods of a multicenter pragmatic randomized controlled trial to evaluate the clinical efficacy and cost-effectiveness of PPEP4All for patients with PDD and their partners/caregivers. In accordance with current recommendations, a mixed methods research approach is used with both quantitative and qualitative data. A total of 178 eligible outpatients with PDD and their partners/caregivers are recruited and randomized to either PPEP4All or CAU. Those assigned to PPEP4All receive nine weekly self-management sessions with a trained PPEP4All therapist. Primary and secondary outcome measurements are at 0, 3, 6, and 12 months.

Discussion

This project will result in the implementation of a self-management intervention for patients with PDD, meeting an urgent need in mental healthcare. Using PPEP4All can optimize the quality and efficiency of care for both patients with PDD and their partners/caregivers.

Trial registration

Netherlands Trial Register Identifier NTR5973. Registered on 20 July 2016.
Adapting the design of a Web-based decision support clinical trial during the COVID-19 pandemic
Authors: Meline Jessica , Prigge Jason M. , Dye Debbie , Rieder Julie , Asan Onur , Chhatre Sumedha , Fraenkel Liana , Kravetz Jeffrey D. , Rodriguez Keri L. , Whittle Jeff , Kaminstein Dana , Schapira Marilyn M.
Published: October 2021

Background

The public health crises that emerged in the COVID-19 pandemic significantly impacted the provision of medical care and placed sudden restrictions on ongoing clinical research. Patient-facing clinical research confronted unique challenges in which recruitment and study protocols were halted and then adapted to meet safety procedures during the pandemic. Our study protocol included the use of a Lung Cancer Screening Decision Tool (LCSDecTool) in the context of a primary care visit and was considerably impacted by the pandemic.

We describe our experience adapting a multi-site clinical trial of the LCSDecTool within the Department of Veterans Affairs Health Care System. We conducted a randomized controlled trial (RCT) comparing the LCSDecTool to a control intervention. Outcomes included lung cancer screening (LCS) knowledge, shared decision-making, and uptake and adherence to LCS protocol. We identified three strategies that led to the successful adaptation of the study design during the pandemic: (1) multi-level coordination and communication across the organization and study sites, (2) flexibility and adaptability in research during a time of uncertainty and changes in regulation, and (3) leveraging technology to deliver the intervention and conduct study visits, which raised issues concerning equity and internal and external validity.

Conclusion

Our experience highlights strategies successfully employed to adapt an intervention and behavioral research study protocol during the COVID-19 pandemic. This experience will inform clinical research moving forward both during and subsequent to the constraints placed on research and clinical care during the COVID-19 pandemic.
Patient and public involvement in randomised clinical trials: a mixed-methods study of a clinical trials unit to identify good practice, barriers and facilitators
Authors: Selman Lucy Ellen , Clement Clare , Douglas Margaret , Douglas Keith , Taylor Jodi , Metcalfe Chris , Lane J. Athene , Horwood Jeremy
Published: October 2021

Background

While patient and public involvement (PPI) in clinical trials is beneficial and mandated by some funders, formal guidance on how to implement PPI is limited and challenges have been reported. We aimed to investigate how PPI is approached within a UK Clinical Trials Unit (CTU)’s portfolio of randomised controlled trials, perceived barriers to/facilitators of its successful implementation, and perspectives on the CTU’s role in PPI.

Methods

A mixed-methods study design, involving (1) an online survey of 26 trial managers (TMs) and (2) Interviews with Trial Management Group members and public contributors from 8 case-study trials. Quantitative survey data were summarised using descriptive statistics and interview transcripts analysed thematically. Two public contributors advised throughout and are co-authors.

Results

(1) 21 TMs completed the survey; (2) 19 in-depth interviews were conducted with public contributors (n=8), TMs (n=5), chief investigators (n=3), PPI coordinators (n=2) and a researcher. 15/21 TMs surveyed reported that a public contributor was on the trial team, and 5 used another PPI method. 12/21 TMs reported that public contributors were paid (range £10–50/h). 5 TMs reported that training was provided for public contributors and few staff members had received any formal PPI training. The most commonly reported tasks undertaken by public contributors were the review of participant-facing materials/study documents and advising on recruitment/retention strategies. Public contributors wanted and valued feedback on changes made due to their input, but it was not always provided. Barriers to successful PPI included recruitment challenges, group dynamics, maintaining professional boundaries, negative attitudes to PPI amongst some researchers, a lack of continuity of trial staff, and the academic environment. Successful PPI required early and explicit planning, sharing of power and ownership of the trial with public contributors, building and maintaining relationships, and joint understanding and clarity about expectations/roles. CTUs have an important role to play in supporting recruitment, signposting and coordinating PPI.

Conclusions

While highly valuable, PPI in trials is currently variable. PPI representatives are recruited informally, may not be provided with any training and are paid inconsistently across trials. Study findings can help optimise PPI in trials and ensure researchers and public contributors are adequately supported.
Reconstructing the right-hand side of the Rayleigh–Stokes problem with nonlocal in time condition
Authors: Duc Phuong Nguyen , Binh Ho Duy , Long Le Dinh , Van Ho Thi Kim
Published: October 2021

In this paper, the problem of finding the source function for the Rayleigh–Stokes equation is considered. According to Hadamard’s definition, the sought solution of this problem is both unstable and independent of continuous data. By using the fractional Tikhonov method, we give the regularized solutions and then deal with a priori error estimate between the exact solution and its regularized solutions. Finally, the proposed regularized methods have been verified by simple numerical experiments to check error estimate between the sought solution and the regularized solution.
Evaluation of a school-based dissemination of the movement guidelines for young children in Hong Kong: Study protocol
Authors: Capio Catherine M. , Ng Catalina S. M. , Chung Kevin K. H. , Jones Rachel A. , Sit Cindy H. P.
Published: October 2021

Background

Healthy movement behaviors in early childhood are believed to track to adulthood, potentially imparting protective benefits against non-communicable diseases. Highlighting the collaborative and complementary roles of parents and educators in promoting health of young children, this study aims to enable parents and teachers to successfully promote healthy movement behaviors in young children. Guidelines for physical activity, sedentary screen time, and sleep of children aged 2 to 6 years will be systematically disseminated to parents and teachers of children enrolled in early childhood education centers (ECECs) in Hong Kong. An evaluation will be conducted to assess the implementation process and the outcomes of the dissemination of said guidelines.

Methods

The evaluation will include formative and summative components to examine the implementation (i.e., process evaluation) and the outcomes (i.e., outcome evaluation). Participants include teachers, parents, and children from ECECs in Hong Kong. The process evaluation will be guided by the RE-AIM framework (i.e., reach, efficacy, adaptation, implementation, maintenance). Data gathering and analysis will take a mixed-methods triangulation design - convergence model. The outcome evaluation consists of a non-randomized observational study, using quantitative data from questionnaires and accelerometers. The primary outcome to be measured is the extent to which children meet the guidelines for physical activity, sedentary screen time, and sleep; the secondary outcome is teachers’ and parents’ knowledge and awareness of the guidelines.

Discussion

Young children who engage in healthy movement behaviors are likely to become adults who will have the disposition to engage in behaviors that have protective effects against non-communicable diseases. The findings of this evaluation are expected to contribute to improving the strategies of systems and government agencies that aspire to promote healthy movement behaviors of young children.
Video block and FABEMD features for an effective and fast method of reporting near-duplicate and mirroring videos
Authors: Adoui El Ouadrhiri Abderrahmane , Jai-Andaloussi Said , Ouchetto Ouail
Published: October 2021

Near-duplicate video content has taken the large storage space in the age of big data. Without respecting the copyright ethic, social media users mirror, resize, and/or hide certain online video content and re-upload it as new data. This research aims to avoid the complex and high-dimensional matching and present an efficient approach for detecting near-duplicate videos, this detection is based on feature extraction using visual, motion, and high-level features. Fast and adaptive bidimensional empirical mode decomposition is used to preserve the relevant data to the furthest extent possible during the low/high-frequency transition and vice-versa. In addition, for a generic model, the invariant moments are added to the aforementioned features in order to reinforce them against different video transformations such as rotating and scaling. Furthermore, the video frames are divided into blocks with a fixed number of features, this set of features is represented by a signature, where its mean and standard deviation represents a single video map allowing easy similarity computation. The F1-score and accuracy are used to evaluate the results of this study; the relevant results are ranked byTop$$_{1}$$1for the best result, and the five top-ranked results are presented byTop$$_{5}$$5. Further, our result ofTop$$_{1}$$1reached over 80% on F1-score, with a difference of ±4% from theTop$$_{5}$$5results, and it is over 90% on Accuracy using different datasets, such as UCF11, UCF50, and HDMB51.
Taxonomic status of grey-headed Yellow Wagtails breeding in western China
Authors: Hellquist Alexander , Friberg Fredrik , Haldén Petter , Schmidt Peter , Ma Ming , Jun Gou , Olsson Urban , Alström Per
Published: October 2021

Background

Field studies from 2011 onwards have demonstrated the presence of a breeding population of Yellow Wagtails (Motacilla flava) in the Xinjiang Uygur Autonomous Region, China that is phenotypically distinct from known subspecies occurring in Asia. Here we describe the plumages and vocalisations of this population and discuss its taxonomic status.

Methods

The analysis of plumage is based on field studies and photos available online. Recordings of vocalisations are compared with recordings from other Yellow Wagtail populations, and differences are analysed based on sonograms. Mitochondrial DNA from one individual is compared to other Yellow Wagtail taxa.

Results

Unlike M. flava subspecies breeding in or near Xinjiang, males in the studied population show a blue-grey head without prominent white supercilium, being most similar to the widely disjunct M. f. cinereocapilla. They differ from the similarly widely allopatric M. f. thunbergi, which might occur as a migrant or vagrant in Xinjiang, by on average cleaner yellow breast and more extensive white on the throat, and from the widely disjunct M. f. plexa and M. f. macronyx, which might also occur on migration in that area, by softer contact calls and slower pace of song. Females are similar to female M. f. feldegg in plumage. The mitochondrial ND2 tree shows the single sample from Xinjiang to be nested in the clade of western Yellow Wagtail taxa.

Conclusion

We discuss whether the Xinjiang breeding population could represent an intergrade between subspecies breeding nearby, or whether it is better regarded as a separate as yet unrecognized subspecies. We argue that the localization of its apparent range in relation to other subspecies along with fairly consistent male and female plumages suggest that it is more likely to represent an undescribed taxon, but conclude that more research is needed to firmly establish its status.
Bubbles in the belly- a case based approach to cystic peritoneal masses
Authors: Patil Savita S. , Shah Parth B. , Kudrimoti Jyoti K. , Nakate Leena A.
Published: October 2021

Background

Primary cystic neoplasms of the peritoneum are rare lesions and not commonly encountered in practice. Many intra-abdominal processes may mimic cystic masses within the peritoneal cavity and pose a diagnostic challenge to both the pathologist and radiologist. Clinical presentation is diverse and varied. These lesions are usually benign. Hence complete surgical excision is the treatment of choice in most of the cases.

Methods

Study design: Descriptive Retrospective study.

Cystic peritoneal lesions were identified and studied from data over a period of 5 years in the Histopathology Section at a tertiary care hospital in Pune, India. Mode of presentation, imaging findings in addition to gross and histopathologic findings of these lesions were studied.

Results

Out of 50 peritoneal lesions studied over a period of 5 years, only 7 were identified to be cystic peritoneal masses.

Of these two were found to be peritoneal cysts, two mesenteric cysts, one an infected mesenteric cyst and one each a mucinous cystadenoma and lymphangioma.

Conclusions

Correct diagnosis rests in the hands of the pathologist and ensures that the patient receives appropriate and timely management. Hence knowledge of the spectrum of these rare cystic peritoneal masses is necessary to distinguish from other potential cystic abdominal mimicker masses and avoid a potential pitfall.
Reconstruction of images in non-scanned confocal microscope (NSCM) using speckle imaging
Authors: Hamed A. M. , Al-Saeed T. A.
Published: October 2021

Background

The common formation of images in CSLM assumes mechanically scanned object placed in the common short focus of the objective lenses of the microscope, while in the arrangement under study, the scanning of the object is realized by placing a diffuser behind the collimating lens. A model is suggested in the formation of images in Confocal Scanning Laser Microscope (CSLM) using non-scanned object. Since the illumination and detection are coherent, the obtained image is constructed from the simple product of the Resultant Point Spread Function (RPSF) modulated by the diffuser spread over the object transparency. Hence, the product of the object and the image of the diffuser replace the mechanical scanning of the object.

Results

Reconstructed images using this novel arrangement of CNSM are presented using mammographic X-ray image.

Conclusions

Convolution of the RPSF and the object is realized by the spreading of the diffuser image over the object. A coherent detector captures the whole image affected by a noisy diffused function. It is noted that image processing is necessary to improve noisy images making use of filtration techniques.
Projected changes in heat load in Carpathian Basin cities during the 21st
century
Authors: Skarbit Nóra , Gál Tamás , Molnár Gergely , Unger János
Published: October 2021

In this study the changes in the nighttime heat load in Carpathian Basin
cities during the 21st century were examined. To quantify the heat load, the
tropical night climate index was used. The MUKLIMO_3 local scale climate
model was used to describe the urban processes and the land use classes were
defined by the local climate zones. The expected change was examined over
three periods: the 1981–2010 was taken as reference period using the
Carpatclim database and the 2021–2050 and 2071–2100 future periods using
EURO-CORDEX regional model simulation data for two scenarios (RCP4.5 and
RCP8.5). To combine the detailed spatial resolution and the long time
series, a downscaling method was applied. Our results show that spectacular
changes could be in the number of tropical nights during the 21st century
and the increasing effect of the urban landform is obvious. In the near
future, a slight increase can be expected in the number of tropical nights,
which magnitude varies from city to city and there is no major difference
between the scenarios. However, at the end of the century the results of the
two scenarios differ: the values can be 15-25 nights in case of RCP4.5 and
30-50 nights in case of RCP8.5. The results show that dwellers could be
exposed to high heat load in the future, as the combined effect of climate
change and urban climate, thus developing various mitigation and adaptation
strategies is crucial.
Data for the geoecology of solution karst dolines, with particular
attention to climatic, soil and biogenic environment
Authors: Bárány Kevei Ilona , Zboray Zoltán , Kiss Márton
Published: October 2021

In this study the changes in the nighttime heat load in Carpathian Basin
cities during the 21st century were examined. To quantify the heat load, the
tropical night climate index was used. The MUKLIMO_3 local scale climate
model was used to describe the urban processes and the land use classes were
defined by the local climate zones. The expected change was examined over
three periods: the 1981–2010 was taken as reference period using the
Carpatclim database and the 2021–2050 and 2071–2100 future periods using
EURO-CORDEX regional model simulation data for two scenarios (RCP4.5 and
RCP8.5). To combine the detailed spatial resolution and the long time
series, a downscaling method was applied. Our results show that spectacular
changes could be in the number of tropical nights during the 21st century
and the increasing effect of the urban landform is obvious. In the near
future, a slight increase can be expected in the number of tropical nights,
which magnitude varies from city to city and there is no major difference
between the scenarios. However, at the end of the century the results of the
two scenarios differ: the values can be 15-25 nights in case of RCP4.5 and
30-50 nights in case of RCP8.5. The results show that dwellers could be
exposed to high heat load in the future, as the combined effect of climate
change and urban climate, thus developing various mitigation and adaptation
strategies is crucial.
Modelling incipient probabilistic grammar change in real time: the grammaticalisation of possessive pronouns in European Spanish locative adverbial constructions
Authors: Marttinen Larsson Matti
Published: October 2021

The present paper provides a methodological case study on how underlying incipient grammar change might be discerned even when frequencies of the incoming variant are apparently marginal and stable. Analysing the spread of tonic possessive pronouns in complements of locative adverbial constructions in European Spanish from a probabilistic perspective, more than 11,000 locative constructions from 1900 to 2004 were compiled, and probabilistic grammar change was operationalised as an interactive function between language-internal predictors and real time. The results reveal that numerous intralinguistic factors have been and are active in constraining the variation, with the innovation spreading significantly in spite of apparent stability in frequency. Crucially, the findings demonstrate that, even in a relatively standardised written language where the innovation has a considerably low frequency, the innovation grammaticalises along the same pathway as in colloquial vernaculars where the incoming variant is employed much more frequently.
The assessment and exploration of forensic nursing concepts in undergraduate nursing curricula: a mixed-methods study
Authors: McFadden Patti
Published: October 2021

Objectives

The purpose of this study was to assess the importance and explore the inclusion of forensic nursing concepts in undergraduate nursing curricula.

Methods

This study used a mixed method design to survey undergraduate nurse educators (n=1,000) across the United States. Utilizing a convergent parallel design, data were analyzed independently, sequentially, and combined to synthesize the results and cultivate the overall conceptualization of the findings.

Results

Significant differences were found about the importance and the integration of forensic concepts in the curricula based on the faculty member’s teaching area and area of clinical practice. Triangulation of data determined faculty valued their role of improving holistic care to victims of violence. However, time, curriculum rigidity, and lack of forensic concept knowledge hindered the inclusion of forensic nursing concepts in curricula.

Conclusions

Findings from this study support the recommendation for faculty development, community collaboration, and utilizing teaching modalities to integrate forensic nursing concepts into undergraduate curricula.
Graphdiyne-decorated microfiber based soliton and noise-like pulse generation
Authors: Ma Wanzhuo , Yin Peng , Li Mengmeng , Sui Lu , Wang Tianshu , Liu Zheqi , Du Lei , Bao Wenli , Ge Yanqi
Published: October 2021

Graphdiyne has an inborn band gap energy, where the minimal band gap is about from 0.46 to 1.22 eV, which shows great potential in ultrafast laser generation. In this work, we fabricate a graphdiyne-decorated microfiber and demonstrate its saturable absorption characteristics experimentally. This device is used as a saturable absorber to generate the conventional soliton and noise-like pulse in an erbium-doped mode-locked fiber laser. The conventional soliton with a spectral bandwidth of 2.45 nm can switch into noise-like pulse with 37.14 nm bandwidth by adjusting the pump power and the polarization controller. For the noise-like pulse, the mode-locked state has excellent stability with 2.17 nJ maximum pulse energy and 283 fs coherent peak duration. This work indicates that graphdiyne could be a remarkable nonlinear photonic device to explore the dynamics of various mode-locked pulses.
Harnessing of inhomogeneously polarized Hermite–Gaussian vector beams to manage the 3D spin angular momentum density distribution
Authors: Khonina Svetlana N. , Porfirev Aleksey P.
Published: October 2021

We propose vector modes based on inhomogeneously polarized Hermite–Gaussian (HG) vector beams, providing complete structural conservation of the beams during propagation. Like uniformly polarized mode beams, these beams provide structural stability (or invariance) of both the intensity and the polarization state, in turn ensuring the stability of other field characteristics, including the angular momentum. We determine the conditions imposed on the HG mode composition in the transverse components of the electromagnetic field in order to control the three-dimensional characteristics of the field, such as intensity, polarization, and spin angular momentum (SAM). For the visual analysis of the polarization state of inhomogeneously polarized beams, we use the transverse distribution of the vector of three Stokes parameters. The correspondence of the third Stokes parameter to the distribution of the longitudinal component of the SAM is used for experimental measurements. The theoretical analysis is clearly illustrated by numerical simulations and confirmed by experimental results.
How Do Norwegian Technology Start-ups Use Open Innovation Strategies to Gain Access to New Business Ideas?
Authors: Rahman Minhazur , Rahman Ummeh Habiba Faria Benteh
Published: October 2021

Open innovation (OI) strategy includes inter-company processes and activities i.e. networking, management, communication etc. The intention of this paper is to present examples on how open innovation performs within these start-ups. This paper is a descriptive study that discusses how to implement open innovation strategies in order to gain access to new business ideas in Norwegian tech companies. Throughout the study and analysis of appropriate literature, this research aims to deepen the understanding of the initial question and provide direction for further research. This improved understanding of using open innovation strategies will help entrepreneurs, as well as policy makers involved in idea evaluation. This study deals with the OI strategy implementation in small companies and startups, both of which are almost untouched fields of study. It contributes recommendations for reality thinking, social media involvement, and planned versus arbitrary strategy. This qualitative research paper forms a case study based on structured interviews with four anonymous Norwegian tech start-ups. Twenty to twenty-five articles about “startups, open innovation and networking” have been selected and analysed for the purpose of this paper. This study outlines a clear method for reviewing the theories of open innovation and networking which are discussed in the objectives. Unlike previous research, this paper will highlight loopholes and common mistakes typically made by start-ups and instead will implement smooth open innovation strategies for their company’s benefit. After conducting successful interviews with start-up, the results have been combined with literature reviews and related theories with empirical evidence to support the proposed question. Finally, the findings are categorised in the table below and organised according to interviewee answers.
Moslems in Europe. Coexistence, cooperation, dia- logue of civilizations
Authors: Babic Irina , Bisson Lyubov , Gadzhiyev Amur , Glashev Akhmay , Kamkin Alexander , Klinova Marina , Lunkin Roman , Rozhin Alexander , Toktamysov Saken , Khayrutdinov Aydar
Published: October 2021

This collective monograph results from the researches of groups of experts in Islamic studies from different regions of Russia. Its articles are joint by the topic of dialogue of Islamic and European civilizations on the territory of the Old World. New times set new challenges: migration, demography, pandemic etc. And sometimes Europeans do not have adequate responses to the new challenges of modernity. This study is the first, but, hopefully, not the last, experience of scientific dialogue on this topic. Russia as the territory of peaceful coexistence of various religions, including Christianity and Islam, can share its experience with European countries, for many of which the dialogue of religions and coexistence of different cultures is a new and complex challenge.
Using Open Resources to Teach Mycology
Authors: Norflus Fran
Published: October 2021

This article discusses a variety of open resources that can be used to teach mycology. Many schools may not routinely teach a mycology class – and if they do, students might not want to invest in a textbook. Options for resale are probably much smaller than with a class in which more students routinely enroll. This article is important in showing both students and faculty how much information about fungi is available online. Some websites are transient, so the reader must carefully check them before use. The sites selected cover most topics that are typically covered in a mycology class. However, depending on faculty emphasis, not all of the information presented in the article may be relevant. These resources should enable faculty to achieve the major teaching objectives in a mycology class, enabling students to gain an appreciation of the diversity of fungi and a basic understanding of their biology, ecology, genetics, morphology, and taxonomy.
An Easy Approach to Understanding Acid-Base Balance in a Blood Buffer System
Authors: Hughes Jonathan M. , Vilchiz Victor H. , Lee Cathy
Published: October 2021

Understanding acid-base disorders using weak-acid concepts learned in general chemistry class is challenging for pre-nursing and pre-professional biology students enrolled in anatomy/physiology and biochemistry classes. We utilized a graphic seesaw model of carbonic acid-bicarbonate equilibrium using the Henderson-Hasselbalch (H-H) equation of a weak acid. We then used real-world clinical case studies for students to identify acid-base disorders and the appropriate compensatory responses of the lungs and kidneys. Students developed a working knowledge of how the bicarbonate blood buffer system maintains a physiological pH of 7.4 using a “seesaw” with metabolic [HCO3−] on one side, and respiratory PCO2 on the other at a ratio of 20:1 in the H-H equation. When the dysfunction of either the kidneys or lungs causes the seesaw to tip, homeostasis pH is disrupted, causing an acid-base disorder classified as metabolic or respiratory acidosis or alkalosis. The functioning organ can “level the seesaw” by compensating for the dysfunction of the opposite organ to regain homeostasis. Unlike traditional ways of explaining acid-base disorders, this graphic seesaw method is a simple and easy way to achieve understanding.
ОСОБЛИВОСТІ СИЛОВОЇ ПІДГОТОВКИ ЖІНОК 30-35 РОКІВ З ВИКОРИСТАННЯМ ТРЕНАЖЕРУ «ФУНКЦІОНАЛЬНІ ПЕТЛІ TRX»
Authors: Дейнеко Альфія , Біленька Ірина , Луценко Лариса
Published: October 2021

Мета: обґрунтувати ефективність використання вправ на підвісних петлях TRX для розвитку силових якостей жінок 30-35 років.

Матеріал і методи: дослідження проводилося протягом року з групою жінок 30-35 років (10 осіб), що займаються оздоровчим фітнесом. Для визначення ефективності використання вправ на підвісних петлях TRX для розвитку силових якостей жінок 30-35 років було використано аналіз та узагальнення літературних джерел, педагогічне спостереження, тестування, педагогічний експеримент, методи математичної статистики.

Результати: аналіз результатів дослідження засвідчив, що після проведення експерименту середньогрупові показники силових якостей жінок 30-35 років виявилися значно вищими у порівнянні з результатами початкового тестування. Їх приріст склав від 4% до 33%. Також порівняльний аналіз результатів жінок досліджуваної групи з використанням критерію Стьюдента показав достовірно кращі показники силової підготовленості майже у всіх тестах (p<0,05; 0,01), окрім тестів «Стрибок вгору з місця» та «Стрибок у довжину з місця», де результат також кращий, проте, він не є статистично достовірним (p>0,05).

Висновки: отримані результати засвідчили ефективність використання вправ на функціональних петлях TRX для розвитку силових якостей жінок 30-35 років.

Ключові слова: розвиток силових якостей, фітнес-програма, жінки 30-35 років, тренажер «Функціональні петлі TRX», вправи.
РОЗВИТОК ГНУЧКОСТІ У ТАЗОСТЕГНОВИХ СУГЛОБАХ У ДІТЕЙ 5-8 РОКІВ ПОЧАТКОВОЇ ГРУПИ СПЕЦІАЛЬНОЇ ФІЗИЧНОЇ ПІДГОТОВКИ З ХУДОЖНЬОЇ ГІМНАСТИКИ
Authors: Сомова Катерина , Ємець Тетяна , Калмикова Юлія , Калмиков Сергій
Published: October 2021

Мета: оцінити ефективність запропонованої методики тренувань для розвитку гнучкості у тазостегнових суглобах у дітей 5-8 років, що займаються у початковій групі спеціальної фізичної підготовки з художньої гімнастики.

Матеріал і методи: у дослідженні брали участь 16 гімнасток початкової групи спеціальної фізичної підготовки з художньої гімнастики у віці 5-8 років, ОГ – 8 гімнасток, які займались за авторською методикою тренування і КГ – 8 гімнасток, які займались за стандартною методикою тренування. Тренування в обох групах проводилось три рази на тиждень по 1,5 години. Оцінка результатів пасивної та активної гнучкості у тазостегнових суглобах застосовувалась у обох групах на початку обстеження та на 22 день тренування за допомогою тестів «Виконання шпагату з гімнастичної лавки» та «Піднімання ноги догори, лежачи на спині» за Л.А. Карпенко, І.А. Вінер, В.А. Савицьким (2007).

Результати: для розвитку гнучкості у тазостегнових суглобах у дітей основної групи, що займаються у початковій групі спеціальної фізичної підготовки з художньої гімнастики, застосовувалась авторська методика тренування, яка включає вправи на розвиток пасивної та активної гнучкості, мотиваційну частину методики, що сприяє позитивним емоціям дітей, підвищенню уваги та зацікавленості результатом тренування.

Висновки: показники розвитку пасивної та активної гнучкості в основній групі були значно вищими (р<0,05), порівняно з контрольною групою, що свідчить про позитивний вплив застосування авторської методики тренування. Вона сприяє покращенню показників активної та пасивної гнучкості у тазостегнових суглобах за рахунок включення комбінованих вправ, що розвивають усі компоненти рухливості у тазостегнових суглобах, вправ динамічного характеру та силових вправ у поєднанні з примусовим розтягуванням.

Ключові слова: активна та пасивна гнучкість, діти, тазостегновий суглоб, художня гімнастика.
ПОКАЗНИКИ ТЕХНІКО-ТАКТИЧНИХ ДІЙ (ОДНОБОРСТВА, ВІДБОРИ, ПЕРЕХОПЛЕННЯ, УДАРИ) ЗБІРНОЇ КОМАНДИ УКРАЇНИ В ІГРАХ 1/8 ТА 1/4 ЧЕМПІОНАТУ ЄВРОПИ 2020-2021 РОКІВ
Authors: Перевозник Володимир , Паєвський Володимир
Published: October 2021

Мета: провести порівняльний аналіз показників техніко-тактичних дій (одноборства, відбори, перехоплення, удари по воротах) збірної команди України у 1/8 з командою Швейцарії та у 1/4 з командою Англії у чемпіонаті Європи.

Матеріал і методи: теоретичний аналіз і узагальнення даних науково-методичної літератури, методи педагогічних спостережень, методи математичної статистики, реєстрація та порівняльний аналіз техніко-тактичних дій (одноборства, відбори, перехоплення, удари по воротах) збірної команди України у 1/8 з командою Швеції та з командою Англії у 1/4 чемпіонату Європи 2020-2021 рр.

Результати: проведено кількісний та якісний аналіз показників техніко-тактичних дій (одноборства, відбори, перехоплення, удари по воротах) збірної команди України у 1/8 зі збірною Швеції та з командою Англії у 1/4 чемпіонату Європи 2020-2021 рр.

Висновки: отримано кількісні та якісні показники виконання ТТД (одноборства, відбори, перехоплення, удари по воротах) збірної команди України у 1/8 з командою Швеції та у 1/4 з командою Англії на чемпіонаті Європи 2020-2021 рр., які свідчать про те, що збірна команда України мала значно вищі кількісні показники ТТД, але якість цих показників значно гірша, ніж у суперників. Порівняльний аналіз якісних показників ТТД (одноборства) збірної команди України зі збірними Швеції та Англії свідчить про те, що вони не відповідають модельним характеристикам, не дивлячись на те, що зі збірною Швеції команда України досягла позитивного результату.

Ключові слова: техніко-тактичні дії, одноборства, футболісти, коефіцієнт браку.
ІНДИВІДУАЛЬНІ ВІДМІННОСТІ У ФОРМУВАННІ ТЕХНІКИ ПЛАВАННЯ ЮНИХ СПОРТСМЕНІВ З РІЗНОЮ СИЛОЮ НЕРВОВОЇ СИСТЕМИ ПРИ ЗАСТОСУВАННІ РІЗНИХ МЕТОДІВ НАВЧАННЯ
Authors: Близнюк Юрій , Політько Олена
Published: October 2021

Мета: дослідити вплив методик формування техніки плавання у плавців 7–8 років і вплив їх індивідуальних особливостей нервової системи на ефективність оволодіння фізичними вправами.

Матеріал і методи: дослідження проводилося протягом трьох місяців з юними плавцями (n=141), які вивчали техніку спортивних способів плавання. Попередньо вони були обстежені на предмет сили нервової системи за збудженням за трьома методиками: руховою – характер наклону кривої (ХНК), теппінг-тест, завадостійкість.

Результати: досліджено вплив різних методів початкового навчання плаванню на успішність становлення рухових умінь у дітей 7–8 років з різною силою нервової системи відносно збудження. Використовувалися репродуктивний метод, проблемне навчання та їх сполучення. Діти були поділені за силою нервової системи на групи: «сильні», «середні» та «слабкі».

Висновки: за результатами досліджень виявилося, що найбільш успішним навчання вправам було при використанні на перших 2–3-х заняттях репродуктивного методу з подальшим використанням проблемного навчання. Щодо дітей з різною силою нервової системи, то згідно з висновками багатьох дослідників середній тип за кількістю перевищує інші типи разом взяті і тому слід орієнтуватися саме на них. Якраз найбільш ефективним для дітей з середньою нервовою системою виявилося вище описане навчання.

Ключові слова: сила нервової системи, методи навчання, плавання.
ПЕРЕВІРКА ПІДГОТОВКИ МАЙБУТНІХ МАГІСТРІВ З ФІЗИЧНОЇ КУЛЬТУРИ І СПОРТУ ДО ДІЯЛЬНОСТІ В УМОВАХ ФІТНЕС-ЦЕНТРУ
Authors: Джуринський Петро , Воробйова Софія , Хом’якова Олена
Published: October 2021

Мета: перевірити ефективність підготовки майбутніх магістрів з фізичної культури і спорту до професійної діяльності в умовах фітнес-центру.

Матеріал і методи: анкетування, тестування, спостереження; статистичні методи, факторний аналіз. У дослідженні взяли участь 34 здобувача другого (магістерського) рівня вищої освіти 1-2 років навчання освітньо-професійної програми (ОПП) «Фізична культура і спорт», спеціальності 017 «Фізична культура і спорт». З метою визначення ефективності підготовки майбутніх магістрів з фізичної культури і спорту до професійної діяльності в умовах фітнес-центру було здійснено анкетування здобувачів другого (магістерського) рівня вищої освіти; визначено рівні сформованості готовності майбутніх магістрів з фізичної культури і спорту до професійної діяльності в умовах фітнес-центру.

Результати: по завершенні формувального етапу педагогічного експерименту показники, що характеризують високий рівень сформованості готовності до професійної діяльності в умовах фітнес-центру, збільшилися у здобувачів контрольної групи з 7,34% до 11,20%, у здобувачів експериментальної групи з 8,44% до 24,12%. Відповідно змінилися дані, що характеризують достатній рівень сформованості готовності до професійної діяльності – у контрольній групі з 44,47% до 52,55%, у експериментальній – з 49,31% до 68,22%. Дані, що характеризують елементарний рівень сформованості готовності до професійної діяльності, зменшилися у контрольній групі з 48,19% до 36,25%, у експериментальній – з 42,25% до 7,66%. По завершенні педагогічного експерименту найбільш значущими структурними компонентами готовності були мотиваційний компонент; когнітивно-рефлексивний компонент; особистісно-діяльнісний компонент.

Висновки: визначено та перевірено ефективність підготовки майбутніх магістрів з фізичної культури і спорту до професійної діяльності в умовах фітнес-центру; удосконалено структуру підготовки майбутніх магістрів з фізичної культури і спорту до професійної діяльності в умовах фітнес-центру; розвитку набули положення щодо розробки і проєктування змісту ОПП «Фізична культура і спорт» з підготовки майбутніх магістрів; визначено критерії та рівні сформованості готовності майбутніх магістрів з фізичної культури і спорту до професійної діяльності в умовах фітнес-центру.

Ключові слова: підготовка, здобувачі, критерії, рівні, фізична культура і спорт, майбутні магістри
An algorithm for solving of Euler parameters differential equations system
Authors: Rédl Jozef
Published: October 2021

The design an optimal numerical method for solving a system of ordinary differential equations simultaneously is described in this paper. System of differential equations was represented by a system of linear ordinary differential equations of Euler’s parameters called quaternions. The components of angular velocity were obtained by the experimental way. The angular velocity of the centre of gravity was determined from sensors of acceleration located in the plane of the centre of gravity of the machine. The used numerical method for solving was a fourth-order Runge-Kutta method. The stability of solving was based on the orthogonality of a direct cosine matrix. The numerical process was controlled on every step in numerical integration. The algorithm was designed in the C# programming language.
Military and Water Governance Practices: A Theoretical Analysis of the Involvement of Indonesian National Armed Forces in the Citarum Harum Project in West Java, Indonesia
Authors: Mustofa Mustabsyirotul Ummah , Brahmantika Shafa Ghaisani Salsabila , Tarigan Bima Riandy
Published: October 2021

The Citarum Harum project as stated in Presidential Regulation No. 15/2018 was created as a response to a report that Citarum is “the dirtiest river in the world”. It is said that the complexity of the management of the Citarum river involves the Indonesian National Armed Forces (TNI) as the program implementer. This military involvement is claimed as a non-war military operation to increase the Citarum Harum program's effectiveness. However, in the discourse of Water Governance, the military is hardly mentioned as an engaged stakeholder, especially in the framework of "governance" which emphasizes the democratic process controlled by civilians. This article seeks to explain what kind of regime can justify the claim of military involvement in water management as a vital public affair. A qualitative approach was used to achieve a comprehensive theoretical analysis in explaining this research problem. The findings indicate that military involvement in water governance is related to security issues, especially water security, and mainly in conflict areas. Meanwhile, in non-conflict areas, water governance places great importance on public and government participation in a very democratic process. Accordingly, the involvement of the TNI in the Citarum Harum program can be said as a practice that has deviated from the shared concept of water governance.
Medida Socioeducativa de Internação e Expectativas de Futuro de Adolescentes e Familiares
Authors: Brondani Renata Petry , Arpini Dorian Mônica
Published: October 2021

Resumo A partir de uma concepção da adolescência construída por fatores intrapsíquicos e socioculturais, este estudo objetivou compreender as expectativas de futuro de adolescentes e familiares no contexto da medida socioeducativa de internação. Para isso, realizou-se uma pesquisa qualitativa, por meio do delineamento de Estudo de Casos Múltiplos, com dez participantes (cinco adolescentes e cinco respectivos familiares) vinculados a uma instituição de cumprimento da medida socioeducativa de internação. Os dados foram coletados em entrevistas semiestruturadas e nos prontuários dos adolescentes na instituição, que foram analisados por meio da síntese de casos cruzados. Os adolescentes mencionaram o desejo de não mais se envolverem com transgressões no futuro, a centralidade que pretendem que o trabalho assuma em suas trajetórias e o anseio por relações familiares mais próximas e afetivas. Já os familiares, que foram, em sua totalidade, as mães dos adolescentes, pretendiam ser mais participativos e ter mais diálogos com os filhos, bem como manifestaram o desejo de que eles se envolvam com o trabalho. Também enunciaram, em seus relatos, incertezas de que os filhos pudessem voltar a se envolver em transgressões. Além disso, os participantes mencionaram a necessidade de saída de seus territórios para não colocar em risco suas próprias vidas. Assim, denota-se a importância de possibilitar reflexões e ressignificações que acompanhem o fim do período da internação, além das iniciativas nas políticas públicas que contemplem o pertencimento e as questões territoriais referentes ao futuro de adolescentes egressos do contexto socioeducativo.
GASTRIC AND ORAL FEEDING IN SEVERE ACUTE PANCREATITIS
Authors: ARROYO-SÁNCHEZ Abel , AGUIRRE-MEJÍA Rosa
Published: October 2021

ABSTRACT BACKGROUND: There is controversy about the initiation of gastric or oral feeding in patients with severe acute pancreatitis (SAP) because they could increase pancreatic stimulation and exacerbate symptoms and complications. OBJECTIVE: To describe the clinical characteristics and results of patients with SAP who underwent gastric tube or oral feeding versus parenteral or jejunal feeding. METHODS: A retrospective study was carried out on patients over 18 years old with SAP diagnostic, who had been treated in critical care units. We excluded patients coming from other hospitals and those with incomplete medical records. RESULTS: Thirty patients with SAP were included, fifty three percent of them tolerated the gastric tube or oral feeding, and most of them were females and older than patients who received parenteral or jejunal feeding. Other clinical characteristics and outcomes were similar in both groups. Conclusion: Gastric tube or oral feeding is no absolute contraindication for SAP.