bluuebunny/crossref_metadata_2025 huggingface dataset:
Proximal Tubular Cell–Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis
Authors: Kruger Claudia , Nguyen Trang-Tiffany , Breaux Chelsea , Guillory Alana , Mangelli Margaret , Fridianto Kevin T. , Kovalik Jean-Paul , Burk David H. , Noland Robert C. , Mynatt Randall , Stadler Krisztian
Published: February 2019

Proximal tubular epithelial cells are highly energy demanding. Their energy need is covered mostly from mitochondrial fatty acid oxidation. Whether derailments in fatty acid metabolism and mitochondrial dysfunction are forerunners of tubular damage has been suggested but is not entirely clear. Here we modeled mitochondrial overload by creating mice lacking the enzyme carnitine acetyltransferase (CrAT) in the proximal tubules, thus limiting a primary mechanism to export carbons under conditions of substrate excess. Mice developed tubular disease and, interestingly, secondary glomerulosclerosis. This was accompanied by increased levels of apoptosis regulator and fibrosis markers, increased oxidative stress, and abnormal profiles of acylcarnitines and organic acids suggesting profound impairments in all major forms of nutrient metabolism. When mice with CrAT deletion were fed a high-fat diet, kidney disease was more severe and developed faster. Primary proximal tubular cells isolated from the knockout mice displayed energy deficit and impaired respiration before the onset of pathology, suggesting mitochondrial respiratory abnormalities as a potential underlying mechanism. Our findings support the hypothesis that derailments of mitochondrial energy metabolism may be causative to chronic kidney disease. Our results also suggest that tubular injury may be a primary event followed by secondary glomerulosclerosis, raising the possibility that focusing on normalizing tubular cell mitochondrial function and energy balance could be an important preventative strategy.
β-Cell–Derived Angiopoietin-1 Regulates Insulin Secretion and Glucose Homeostasis by Stabilizing the Islet Microenvironment
Authors: Park Ho Seon , Kim Hak Zoo , Park Jong Suk , Lee Junyeop , Lee Seung-Pyo , Kim Hail , Ahn Chul Woo , Nakaoka Yoshikazu , Koh Gou Young , Kang Shinae
Published: February 2019

Islets are highly vascularized for prompt insulin secretion. Although angiopoietin-1 (Ang1) is a well-known angiogenic factor, its role in glucose homeostasis remains largely unknown. The objective of this study was to investigate whether and how Ang1 contributes to glucose homeostasis in response to metabolic challenge. We used inducible systemic Ang1 knockout (Ang1sys−/−) and β-cell–specific Ang1 knockout (Ang1β-cell−/−) mice fed a high-fat diet for 24 weeks. Although the degree of insulin sensitivity did not differ between Ang1sys−/− and Ang1sys+/+ mice, serum insulin levels were lower in Ang1sys−/− mice, resulting in significant glucose intolerance. Similar results were observed in Ang1β-cell−/− mice, suggesting a critical role of β-cell–derived Ang1 in glucose homeostasis. There were no differences in β-cell area or vasculature density, but glucose-stimulated insulin secretion was significantly decreased, and PDX-1 expression and GLUT2 localization were altered in Ang1β-cell−/− compared with Ang1β-cell+/+ mice. These effects were associated with less pericyte coverage, disorganized endothelial cell ultrastructure, and enhanced infiltration of inflammatory cells and upregulation of adhesion molecules in the islets of Ang1β-cell−/− mice. In conclusion, β-cell–derived Ang1 regulates insulin secretion and glucose homeostasis by stabilizing the blood vessels in the islet and may be a novel therapeutic target for diabetes treatment in the future.
Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy
Authors: Thounaojam Menaka C. , Montemari Annalisa , Powell Folami L. , Malla Prerana , Gutsaeva Diana R. , Bachettoni Alessandra , Ripandelli Guido , Repossi Andrea , Tawfik Amany , Martin Pamela M. , Facchiano Francesco , Bartoli Manuela
Published: February 2019

We have investigated the contributing role of monosodium urate (MSU) to the pathological processes associated with the induction of diabetic retinopathy (DR). In human postmortem retinas and vitreous from donors with DR, we have found a significant increase in MSU levels that correlated with the presence of inflammatory markers and enhanced expression of xanthine oxidase. The same elevation in MSU levels was also detected in serum and vitreous of streptozotocin-induced diabetic rats (STZ-rats) analyzed at 8 weeks of hyperglycemia. Furthermore, treatments of STZ-rats with the hypouricemic drugs allopurinol (50 mg/kg) and benzbromarone (10 mg/kg) given every other day resulted in a significant decrease of retinal and plasma levels of inflammatory cytokines and adhesion factors, a marked reduction of hyperglycemia-induced retinal leukostasis, and restoration of retinal blood-barrier function. These results were associated with effects of the hypouricemic drugs on downregulating diabetes-induced levels of oxidative stress markers as well as expression of components of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome such as NLRP3, Toll-like receptor 4, and interleukin-1β. The outcomes of these studies support a contributing role of MSU in diabetes-induced retinal inflammation and suggest that asymptomatic hyperuricemia should be considered as a risk factor for DR induction and progression.
Doluluk Oranlarının PLA ve PET Malzemelerin Mekanik Özellikleri Üzerine Etkileri
Authors: EVLEN Hatice , ÖZDEMİR Merve Ayfer , ÇALIŞKAN Aydın
Published: February 2019

Gerçekleştirilen çalışmada, yığma teknolojisi ile üretim yapan bir yazıcı
modellemek ve modellenen üç boyutlu yazıcıda doluluk oranının mekanik
özellikler üzerine etkilerinin incelenmesi amaçlanmıştır. Bu amaç kapsamında
kartezyen tipi açık kaynaklı bir üç boyutlu yazıcı modellenmiştir. Prototip
imalatı yapılan üç boyutlu yazıcı kullanılarak PET ve PLA malzemelerin %10, 20,
30, 40 ve %50 doluluk oranlarında mekanik test numuneleri yazdırılmıştır. Elde
edilen numuneler tek eksenli çekme testleri tabi tutulmuş, sertlik ve
pürüzlülük değerleri ölçülmüştür. Yapılan ölçümler neticesinde PET ve PLA
malzemelerde sertlik değerinin malzemenin doluluk oranı ile doğru orantılı
olduğu, doluluk oranı arttıkça malzemelerin sertliklerinin de arttığı
görülmüştür. PLA ve PET malzemelerden üretilen numunelerin pürüzlülük ve çekme
değerlerinin birbiriyle ters orantılı olduğu, pürüzlülük ve çekme mukavemeti
değerlerinin %30 doluluk oranından itibaren 
%10 ve %20 doluluk oranındakinin aksi yönde seyrettiği görülmüştür.
Licenciaturas Interculturais: estudo de caso dos acadêmicos indígenas Fulni-ô
Authors: Barbosa da Silva Gabriela Kássia , Ferreira Paulino Suzana
Published: February 2019

A universidade é um espaço que congrega diversos segmentos sociais e, em se tratando dos acadêmicos indígenas, cada um tem sua origem em determinado grupo étnico, com uma língua própria - característica que os identifica. Partindo do fato de que cada acadêmico indígena teve seu ensino básico dentro de sua comunidade, bem como um contato direto com sua língua materna no seu cotidiano, há que se reconhecer a existência de um choque linguístico-cultural quando o mesmo ingressa na universidade. Diante disso, a universidade deve se pautar em uma conduta de reconhecimento dessa trajetória educativa específica indígena, produzindo conhecimento de acordo com os valores e tradições desses povos, objetivando um processo de ensino-aprendizagem constante, coletivo e inclusivo. Nesse contexto, a presente pesquisa teve como objetivo geral discutir os desafios para o acesso e permanência de um povo indígena no ensino superior no atual contexto sociocultural brasileiro, a partir de dados relatados por acadêmicos indígenas Fulni-ô de Águas Belas/ PE.
Ensino e aprendizado na universidade: a percepção de estudantes em uma perspectiva fenomenológica
Authors: Saraiva de Melo Fabiola Freire , Reis Bruno Miguel Carriço dos
Published: February 2019

O crescimento do acesso ao ensino superior trouxe novas e importantes questões com as quais a universidade não estava preparada para lidar. A insatisfação manifestada por docentes e estudantes no âmbito universitário nos chama a olhar para a crise que se acentua. Para compreender tal questão, precisamos refletir sobre os diversos e diferentes elementos que constituem a sua problematização, destacando aqui os aspectos políticos, sociais, econômicos, mas, principalmente, os pedagógicos e psicológicos que podem nos ajudar a compreender tal problemática. Para tal, nos propusemos a perguntar aos alunos e alunas de uma universidade particular sobre essa experiência. Procuramos analisar a percepção destes acerca da instituição universitária (recursos e condições de funcionamento), das práticas pedagógicas (métodos de docência e relação com os docentes) e das suas expectativas pessoais e profissionais enquanto graduados. A investigação foi feita na perspectiva fenomenológica, que busca uma aproximação da experiência vivida e procura que a experiência se revele para conhecê-la. Assim, foram entrevistados oito estudantes de uma universidade particular, em dois grupos com quatro estudantes, com o intuito de conhecer suas percepções. A partir de seus relatos, identificamos três unidades de sentido que configuram existencialmente o fenômeno estudado: 1) “relação do aluno(a) com a universidade”; 2) “relação do aluno(a) com professores” e 3) “relação do aluno(a) com o aprendizado”. A relação do aluno com a universidade foi trazida pelos entrevistados(as) como uma relação muito importante, porém marcada por frustrações. Revelaram muita insatisfação com a estrutura da universidade, com as metodologias dos professores, com as exigências feitas por esses e com o sistema de avaliações a que estão submetidos. Um dos aspectos evidentes é a relação mercadológica com o ensino e o “novo” perfil de aluno que tem ingressado no ensino superior. A percepção dos estudantes acerca da universidade e seu processo de aprendizado toca em questões nevrálgicas da crise universitária e revela de modo explícito a necessidade de uma nova cultura universitária, atrelada ao contexto social de rápidas transformações e indeterminações a que os estudantes estão submetidos e com os quais não sabem lidar. Atrela-se a isso a necessidade de mudança no paradigma educacional de ensino dos docentes para que favoreçam uma aprendizagem dinâmica, significativa, e que possibilite a construção de projetos de futuro. Discutir sobre o sentido da universidade e refletir sobre o trabalho que enquanto docentes realizamos, constitui um processo imprescindível para melhorar o nível de conhecimento sobre nosso modo de ensinar, e o que ensinar, para que a universidade possa rever seu papel.
Streaming, produção, tecnologia e campo musical
Authors: Silva Igor Fediczko
Published: February 2019

O consumo e a produção da música mudaram com os serviços de streaming? Entrevistamos diversos personagens que atuam no mercado musical, como produtores, músicos, engenheiros e até mesmo executivos, para trazer novas perspectivas à essa resposta. Esse foi um dos objetivos da pesquisa de mestrado chamada “Streaming: produção, tecnologia e campo musical”, defendida em novembro de 2018 na PUC. Apresentamos aqui o resultado das entrevistas seguido de algumas observações.
Pensamento ameríndio e a ideia de América Latina
Authors: Siracusa Gabriel Pietro
Published: February 2019

O artigo visa discutir a noção “América Latina”. Após passar brevemente pelas origens do termo e seus usos variados no decorrer da história, tentaremos defender a possibilidade de uma visão da América que parta dos povos originários. Como o pensamento Ameríndio conceberia nosso subcontinente? A partir de quais pressupostos? Qual seria, enfim, a visão de Caliban a respeito de si e de sua ilha, para falarmos com a metáfora shakespereana? Nossa sugestão será que a partir da reflexão Ameríndia podemos propor uma noção de América Latina mais ampla, capaz de abarcar a diferença e o Outro, em contraposição à visão recorrente na história de uma América Latina branca e elitista.
Cultura digital, cultura hacker e novas formas de atuação de movimentos sociais: um estudo de caso sobre o Ônibus Hacker
Authors: Leitão Gabriela Nardy V. , Araújo Rafael De Paula Aguiar
Published: February 2019

Este trabalho tem como objetivo investigar como a cultura hacker e a cibercultura impactam as atuais lutas por mudanças sociais e políticas e a visão dos membros do Ônibus Hacker acerca de seus modos de organização e significados de horizontalidade, abertura e flexibilidade organizacionais. Também se buscou entender como a ética hacker poderia trazer respostas a questões presentes em grupos de ações coletivas, como problemáticas relacionadas à estrutura organizacional, individualidade e cooperação entre pessoas com visões de políticas distintas.
Quando o indivíduo se transforma: reflexões a partir de Mead, Goffman e Garfinkel
Authors: Figueredo Benzaquen Guilherme
Published: February 2019

O artigo pretende refletir sobre como a teoria sociológica aborda a questão da crise no e do indivíduo. Para tanto, irei partir de Mead e suas análises pragmatistas sobre o self para depois abordar, de forma comparativa, as transformações do indivíduo em Goffman e Garfinkel. Os três autores serão postos em diálogo e esse esforço analítico possibilitará uma análise de como desenvolveram suas teorias principalmente suas concepções de indivíduo, ação social e ordem social.
Estratégias de Internacionalização de Empresas Multinacionais Brasileiras Fabricantes de Implementos Agrícolas: Estudo de Dois Casos
Authors: Rovai Ricardo Leonardo , Da Costa Priscila Rezende , Ferraz Renato Ribeiro Nogueira
Published: February 2019

O objetivo geral deste trabalho é analisar as estratégias de internacionalização das empresas multinacionais brasileiras fabricantes de implementos agrícolas. Para realização do enquadramento teórico-empírico são adotadas as Tipologias de Dunning, da Escola Nórdica e as Dimensões Culturais de Hofstede. Para tal, são analisados dois casos pilotos de empresas concorrentes que possuem características muito semelhantes em termos de estrutura organizacional. Este estudo evidenciou em que medida o alinhamento estratégico está orientado a metas considerando: (i) exploração de recursos naturais e vantagens de custos de mão de obra não qualificada (resource seeking); (ii) vantagens de localização e sinergias de mercado (market seeking); (iii) investimentos orientados à busca de ativos estratégicos do tipo efficiency seeking (aquelas que buscam racionalizar a produção e explorar economias de especialização e localização); (iv) investimentos do tipo strategic asset seeking (voltados à aquisição de recursos e competências com o objetivo de incrementar sua competitividade por meio de da inovação e crescimento das capacidades estratégicas).
Cenários Prospectivos para a Competitividade do Varejo de Veículos no Brasil em 2040
Authors: Da Rocha Marcelo , Sarfati Gilberto
Published: February 2019

A indústria automobilística parece diante de grandes mudanças e transformações. O setor sempre se caracterizou por ser muito dinâmico e pioneiro no desenvolvimento de novas tecnologias, sejam elas de caráter produtivo ou de produto. O pilar desta indústria foi construído sob o modelo de propriedade particular dos veículos. Este cenário começou a mudar mais notadamente a partir da crise econômica de 2008 com o surgimento e popularização de plataformas de compartilhamento de bens, que podem mudar a propriedade veicular em torno do veículo como um serviço. O objetivo deste trabalho é explorar e analisar possíveis cenários prospectivos para a indústria de distribuição de verículos no país em 2040.Foram desenvolvidos quatro cenários em torno das forças motrizes desenvolvimento tecnológico e comportamento do consumidor - Democratização da mobilidade, A vez do consumidor, Nada de novo e Onde vamos parar. O trabalho conclui que a evolução da indústria está ocorrendo e a disrupção chegando. Embora não haja certeza em nenhuma previsão futura, é bastante claro que o modelo de concessionária de hoje - baseado principalmente em vender um veículo de cada vez para indivíduos e depois atender a esses carros em suas oficinas - não sairá ileso em um mundo de compartilhamento, veículos eletrificados, conectados e autônomos.
Estudo sobre a Influência do Posicionamento de Marca no Desempenho Competitivo das Organizações
Authors: Mourad Aimãn Ibrahim , Serralvo Francisco Antonio
Published: February 2019

Ter um posicionamento diferenciado é indispensável para a organização sobreviver em alguns mercados altamente competitivos, globalizados e velozes em termos tecnológicos. O posicionamento é considerado um dos elementos-chave na gestão de marketing moderna, porém, o termo posicionamento tem apresentado certa confusão entre profissionais de marketing e acadêmicos. Utilizando o mind share e o market share como variáveis mensuráveis do posicionamento de marca e do desempenho competitivo, respectivamente, o presente trabalho buscou como objetivo principal identificar quanto o posicionamento de marca pode influenciar no desempenho competitivo de uma organização. Para isso, foi utilizada uma abordagem quantitativa em uma desk research longitudinal e aplicou-se a técnica de correlação de Spearman. Não foi possível apontar se o posicionamento de marca é determinante do desempenho competitivo, contudo, concluiu-se que este exerce influência moderada no desempenho da organização, dado que o período analisado apresentou correlação positiva moderada entre as variáveis, indicando que estas movimentam-se na mesma direção e que quanto maior o crescimento de uma variável, maior a probabilidade de ocorrer o mesmo com a outra, contribuindo com estudos anteriores. Este estudo também corrobora na definição e distinção em relação aos conceitos de posicionamento de marca e posicionamento competitivo, além de propor a utilização da identidade como elemento direcionador para a estratégia de posicionamento de marca.
Morphology Characteristics of Rattan (Calamus SP.) Tourism Forest In Bariat The South Sorong Regency
Authors: Irnawati Irnawati , Nanlohy Lona
Published: February 2019

Rattan grows naturally inbeaches and mountains. Ecologically, it could grow rapidly in various places especially with high humidity areas such as riverside. The research conducted to identify and discover the morphology characteristics of botanical rattans which are being used by the local communities in Bariat natural Park Forest.Theresults of this research can be used for the cultivation and conservation of rattan (calamus SP.). The methodology of research is descriptive which is conducted with field visits. The first samples were collected randoml, however, the second and third sample was collected systematically. These collection method  to determine the distribution of rattan growth. Five types of rattan were found in the research area which is divided into three classifications. Two of them are classified as Calamus, the other two are Daemonorops and the last one is Korthalsia. Turning into the way of the rattan grow in Bariat, four of them grow as clumping plants while the other one is single trunk (solitary). In Bariat, the rattan has low diversity but high quantity. It is potentially to be used as a source of biodiversity which has high economy value for the local community
Targeted nanomedicines for applications in preclinical cancer models
Authors: Marchiò S , Bussolino F
Published: February 2019

Despite substantial advancements in cancer management, a considerable proportion of patients cannot yet be cured. Strategies to address this open medical need are actively pursued and include two main approaches: 1) optimizing diagnostic protocols to detect tumors at early stages, and 2) designing personalized therapies to increase efficiency and selectivity of clinical interventions. Our recent work has been directed to a rationally-designed implementation of both approaches. Particularly, we have contributed to the development of nanomedicines that can be targeted to diseased tissues for theranostic purposes in preclinical models of human cancers. Such modular nanoscale systems proved to be versatile platforms to combine imaging and drug delivery for applications in the oncological field and could be a basis for future improvements.
Peer Assessment in Writing: A Critical Review of Previous Studies
Authors: Gupta Sonia Dutta , Abdullah Fatimah , Li Gu , Xueshuang Yang
Published: February 2019

Peer assessment has attracted more attention an effective assessment tool in recent years. Peer assessment refers to the arrangement for peers to consider the quality of learning outcomes of others of similar status, it received attention of various studies due to the growing interest in the student centered approach as learners need to be involved in the learning process even in the assessment. This paper is a critical review of previous studies on peer assessment in English as Second/Foreign Language (ESL/EFL) context. Fifteen peer assessment studies from 2004 to 2017 were extensively reviewed and systematically analyzed. Peer assessment of  the reviewed studies were on the quality of the writing outcomes of students in the EFL/ESL contexts, as writing skill occupies an important role in teaching English language.  As a critical review paper of these studies, this paper highlights practical use of peer assessment and the important challenges or issues that need to be considered when utilizing peer assessment in the classroom. This paper hopes that practical measures of peer assessment will be utilized effectively by educators in the ESL and EFL classrooms in the near future.
A Comparative Study of Natural Sciences as a Miracle and Natural Laws: A Case of Historical Linguistics
Authors: Barati Farajollah , Divani Amir , Javadi Mohsen , Ali Zamani Amir Abbas
Published: February 2019

This study investigated the comparison of instructing natural sciences as a miracle and natural laws through the comparative linguistic process from Eastern and Western scholars perspectives. This study may provide some evidence on the problems the teachers face in designing a new method of using cause and effect processes speaking skills. This may help the English language learners to follow these processes in speaking and class discussions in a comparative study of Western and Eastern approaches to class discussion. The method of this study was based on historical design. The participants filled in a researcher-made questionnaire to compare their views on the two major schools of Eastern and Western thoughts referring to the schools contributions to teach causality. Data were analyzed and the results showed that both schools have relied on their background perspectives on religious thoughts. Therefore, the main findings of this study focuses on the compromise of East and West to make a unique method in instructing cause and effect processes.
The Aftermath of Hurricane Katrina
Authors: Brown Angela Khristin
Published: February 2019

Huricain Katrina was a natural disaster that had a negative response on the political, economical, sociological and evironmental affects in America. In light of what happened, the levies should be rebuilt to become more secure, land sites should be cleaned up and small shops, restaurants and an historical museum should be made to perserve New Orleans culture. Many contributions should be made to recreate the atmosphere that was lost by Hurricane Katrina by many toursist who would visit this historic site to have a memorable experience of New Orleans culture.
Meiteis Naming Practice
Authors: Singh Aboy Yumnam
Published: February 2019

This paper mainly attempts to describe the naming practice of Meiteis. Such study is an important linguistic aspect in Meitei society. It also studies the different periods of giving Meiteis personal names, the order of names and the categories of given names. The study of Meitei naming practice will give a deep knowledge insight into language of Meitei, culture, philosophy, belief, religion, thought and social changes.
The Greatest Defender of Truth shall Remain in the eye of a Poet
Authors: Brown Angela Khristin
Published: February 2019

It has been created within the larger realm culture, in that "Black methodology differs from mostcolonialdifferences by members of a minority community who reside within a nation of cultural biases."
Who Are You Re? The Pragmatic Implication of Fela Kuti's Question
Authors: Bamigboye Omolade
Published: February 2019

The paper adopts a pragmatic approach to the understanding of a question posed by the late Fela Anilulapo-Kuti in one of his evergreen musical compositions. The underlying meaning of a borrowed word in the expression is systematically investigated with a view to determining its actual purpose and comprehension with respect to the peculiar Nigerian linguistic environment. The finding is that the word conveys an underlying meaning sensitive only to its contextual occurrence. The paper concludes that more attention be paid to the infusion of foreign words in the contextual use of language.
Is The Implementation Of Self-Assessment Effective In Improving The Iranian EFL Students' Writing?
Authors: Rahmanpour Farzaneh , Janfaza Abusaied , Soori Afshin
Published: February 2019

Writing skill is an important skill which is a requirement for the future success of a learner, and providing feedback by teachers on the students' writing a challenging issue. Self-assessment is almost a new trend in writing instruction. This study tries to investigate the effectiveness of the implementation of self-assessment in a writing classroom. To this end, 46 Iranian university students in Islamic Azad university, Kerman, Iran served as the participants of this study. The students were studying in English field of study. They were in a range of 20 to 24 who had taken the writing course voluntarily. In terms of the result of the proficiency test, the students were assigned randomly into two groups (an experimental and a control group). The students in the experimental group used self-assessment method and the students in the control group used the teacher assessment (traditional method) in the classroom. The findings of the current study revealed that the implementation of the self-assessment was helpful in the writing classroom and improved the overall abilities of the Iranian students.
A Sociolinguistic Study of Muslim and Christian Wedding Invitation Genre in the Jordanian Society
Authors: Mohammed Sawalmeh Murad Hassan
Published: February 2019

This study aims at examining the generic structure of Muslim and Christian wedding invitation genre in the Jordanian society. It is a sociolinguistic study. The researcher believes that considering many aspects of these invitation cards such as form, structure and so forth, may provide a lot of information about the social dimensions of those who tend to hold a wedding ceremony. The data are elicited through a questionnaire that consists of twenty-five items compiled from invitation cards for both Muslims and Christians. The findings of the study show that the form of the invitation cards in Islam and Christianity in the Jordanian society is systematic and influenced by social, economic, and religious factors. Finally, this study recommends that further research to be conducted investigating other invitation cards for other events in the Jordanian society such as invitation cards for attending meetings, lectures, celebrations, royal feasts, tribal reconciliation, etc.
A DIACHRONIC STUDY OF THE NP STRUCTURE IN GHANAIAN NEWSPAPER EDITORIALS
Authors: Afful Isaac
Published: February 2019

In the last few decades, researchers have grown much interest in analyzing the structure of the NP in various domains. Dwelling on Quirk et als (1985) framework on NP complexities, this study investigates the NP structure in editorials form the Daily Graphic. Being a diachronic study, nine editorials form 1988, 1998 and 2008 were analysed. The analysis and discussion point to two key findings. First, there has been a gradual increase in the use of Head + PP structures in Ghanaian newspaper editorials. Second, the Determiner+Head has been the most preferred structure of premodification in editorials. These findings have implications for print media discourse, Historical linguistics and for further research.
A comparative study of teachers perspectives in city center of Fars and its remotest towns or villages toward high schools' Junior Secondary book
Authors: Bagheri Masoud , Karampour Fatemeh
Published: February 2019

Regarding the textbook evaluation a whole slew of studies are done and each of which is taken into account different aspects of the books. Since the book entitled Prospectone is a recently released one and there was no investigation about it the researcher decided to scrutinize it. The investigator administered a questionnaire and a semi-structured interview. The study was intended to investigate and compare the teachers perspectives in center of Fars Province and in its remotest villages or towns such as Lamerd, Mohr, Galedar, Ashkanan and Alamarvdasht. A total population of 100 people participated in this research. To gather the data, Litz questionnaire was used.  Regarding the obtained findings from the questionnaires and semi-structures interviews, it revealed that the teachers in remotest villages ran through more difficulties. And it is believed that most of their problems are due to the lack of background knowledge. The learners who attended grade7th had no background knowledge in English. As Krashen(1975) stated the input that the learners receive should be comprehensible and one level higher than the student immediate knowledge.Â  Although most of the learners in Fars province participated in extra curricular classes, mostly institute classes, the students in rural places had never attended in any. Another revealed result is that there was not any balance between the skills in the book and most of the empathies are on oral skills. To put all the aforementioned statements into a nutshell, it can be said that there is a big gap between students current knowledge in Fars province and the ones in villages.
Gender and Number Agreement in the Oral Production of L1 Arabic Among Bilingual Arab-Americans
Authors: Al-shammari Khalid
Published: February 2019

Bilingualism means the ability to communicate in two languages and in some cases,with better skills in one language versus the other. Most bilinguals have one language that ismoredominant than the other due to sequential acquisition.That is, the dominant language is used in everyday communication and in school. Heritage languages are immigrant languages
Effect of Empathic Tones on Spelling Ability among Native Arab Children
Authors: Ibrahim Raphiq , Badarny Samih
Published: February 2019

Little research has been conducted on the development of spelling in general and in the Arabic language in particular. In this research, we intend to examine the effect of empathic tones in words on the accuracy of spelling. The study included 162 elementary school children. They were asked to spell concrete nouns, including frequently and less frequently used words, from literary and spoken Arabic containing both empathic and non-empathic tones. Significant effect of empathic tones on spelling accuracy was found. This manifested itself in a better spelling performance of words without empathic tones than in words with empathic tones. The research results reinforce a specific characteristic of Arabic orthography and emphasize the need for appropriate intervention to improve the spelling abilities of children.
A politics of the Performativity in Forming of the Gender Identity
Authors: FARHADY Morteza , GOLGIRI Rahil
Published: February 2019

This study is an attempt to examine the role of performativity in forming and determining gender identity in a society. This study included articles and books that were written about language, gender, identity of a gender and also politics of performativity. These studies were analyzed qualitatively and quantitatively. The result of these analyzing shows gender identity is not natural or innate. Rather it takes its meaning from the inside of a person. This formation is influenced by the thoughts and ideas of society about gender and identity. It is clear gender and also gender identity constructed by language, then language goes into behavior, it, finally, begins to shape peoples identities. It means that gender and identity of gender are formed and determined by language and behavior; peoples acts.
New Drug Delivery Systems Concept in Anaesthesia and Intensive Care—Controlled Release of Active Compounds
Authors: Bratu Tiberiu , Dinu Anca , Sandesc Mihai , Popovici Sonia Elena , Dragoi Razvan Gabriel , Elena Amaricai , Sandesc Dorel
Published: February 2019

With time, medical and pharmaceutical research has advanced significantly. However, one of the major issues is how to administer the active substance. Among these, it counts over- or under-dosage of the active substance, low re­sponse to treatment, or increased clinical risk of the patient. An innovative method able to avoid these obstacles is represented by controlled release systems for active substances. The interest for these systems came with allowing encapsulation in the antibiotic release matrices, local anesthetics, protein or other substances. Moreover, a number of such vehicles are now available to release controlled substances used predominantly in the anesthesia and intensive care unit.
«Existir» e «existência» em Platão
Authors: Trindade José
Published: February 2019

Parmenides’ argument in the Way of Truth and Plato’s theory of Forms are usually seen as mighty metaphysical constructions. But what if they are motivated by the semantic complexity of the Greek verb ‘be’? This is the approach followed throughout this paper, mostly dealing with the debate on the emergence of a separate existential reading of ‘einai,’ and the problems arising from the use of the Latin verb ‘existere’ to translate it. The analysis of some sophistic puzzles provides examples of this fused reading of the verb. They suggest that Plato’s philosophical program was intended as a correction of current sophistic views on reality and discourse, both through his theory of Forms, and the analysis of being and not being, carried out in the Sophist.
COMPARAÇÃO FENOLÓGICA DE ESPÉCIES DA FAMÍLIA BIGNONIACEAE EM UMA ÁREA DE REFLORESTAMENTO E EM ÁREAS URBANAS
Authors: SOUZA Andreia Estela Moreira , Papa Adriana Cristina , Almeida Silva Gabriela de
Published: February 2019

Fenologia é o estudo das fenofases, ou seja, época de brotação, floração, frutificação e dispersão de sementes, sendo essencial para pesquisas de reprodução que visam a recuperação de áreas degradadas. O trabalho objetivou investigar o padrão fenológico de espécies da família Bignoniaceae em uma área de reflorestamento do campus II da FUNEC- Santa Fé do Sul, comparando com espécies da área urbana. Foram registrados aspectos qualitativos de floração, frutificação, abscisão e brotamento foliar e quantitativos de diâmetro a altura do peito (DAP), altura e pH do solo.  A área de reflorestamento apresenta aspectos de mata estacional semidecidual, com abscisão foliar no perí­odo de seca. Em relação a fenologia, os espécimes de Jacaranda mimosifolia da área de reflorestamento e urbana apresentaram o mesmo perí­odo de florescimento e frutificação. Não foi observada floração em nenhum Ipê (Tabebuia e Handroanthus) da área de reflorestamento. Na área urbana, floresceram no período esperado, não sendo a temperatura e pluviosidade fatores limitantes. Análises do solo da área de reflorestamento revelaram pH 5, adequado ao florescimento uma vez ser essa uma espécie de cerrado. Embora os Ipês dessa área tenham oito anos e, portanto, já em fase de florescimento, as condições do solo podem tê-lo atrasado. Conclui-se que a ausência de floração e frutificação dos Ipês na área de reflorestamento possivelmente relacionada-se com a escassez de micro e/ou macronutrientes no solo. Os Jacarandás floresceram e frutificaram de acordo com a época esperada, revelando que as condições da área de reflorestamento não foram limitantes para todas as espécies.
Uji Prestasi Pesawat Terbang Wing In Ground Effect Saat Hydro Planning
Authors: Syamsuar Sayuti
Published: February 2019

Fase take off merupakan saat kritis pada pesawat wing in ground effect dimana terjadi moment pitching positif yang membesar. Caya hambat air pada titik pusat buoyansi dari hull, gaya angkat aerodinamika pada titik pusat tekanan dari sayap, gaya propulsi dan gaya berat pada titik pusat gravitasi dalam keadaan tidak dalam posisi seimbang saat hydro planning. Sayap jenis inverse delta dengan bentuk punduk diatasnya dan airfoil jenis Clark Y mempunyai luas sayap sebesar 31.75 m2• Koefisien gaya angkat dan gaya hambat aerodinamika dihitung dengan menggunakan piranti lunak DATCOM. Sayap horizontal pada ekor menggunakan airfoil NACA 0012 dan sayap vertikal pada ekor mempunyai airfoil simetri NACA 0015. Ponton dan winglet dipasang pada bagian ujung luar sayap. Kurva hambatan air dari hull diperoleh perhitungan analisis dan uji model di towing tank. Uji thrust dan penimbangan berat pesawat sudah dilakukan di hanggar. Kesimpulan dari hasil uji terbang mengatakan bahwa terjadi kondisi kelebihan berat, tidak tepatnya posisi titik pusat gravitasi sehingga diperlukan tenaga mesin yang lebih besar untuk meneruskan fase takeoff.
Analisa Rencana Overlay Landas Pacu Bandar Udara Iskandar Pangkalan Bun, Terhadap Equivalent Single Wheel Load (ESWL) Pesawat Boeing 737-900 ER
Authors: Muliasari Ataline , Purnama M Herry
Published: February 2019

Bandar udara Iskandar yang terus berupaya meningkatkan kualitas pelayanan penerbangan bagi masyarakat pengguna, berencana melakukan pengembangan fasilitas landas pacu dari 1.850 meter menjadi 2.250 meter. Pemanjangan fasilitas landas pacu sepanjang 350 meter ini diharapkan agar pesawat udara berbadan lebar dapat mendarat di bandar udara Iskandar yang saat ini baru dapat didarati oleh pesawat dengan tipe 737500. Analisa rencana overlay landas pacu bandar udara Iskandar Pangkalan Bun, terhadap Equivalent Single Whell Load (ESWL) pesawat Boeing 737-900ER ini dilakukan dengan tujuan untuk mengetahui ketebalan rencana lapisan perkerasan landas pacu yang akan di overlay terhadap equivalent single wheel load (ESWL) pesawat hoeing 737-900 ER. Sementara itu, perurnusan masalah dari pengkajian ini adalah apakah rencana tebal perkerasan overlay fasilitas landas pacu di Bandar Udara Pangkalan Bun telah memenuhi persyaratan untuk dapat didarati pesawat tipe Boeing 737-900 ER. Bandar Udara Iskandar pangkalan Bun akan melakukan overlay setebal 7,5 cm. sehingga flexible pavement yang semula setebal 80 cm akan menjadi setebal 87,5 cm. tetapi, dari hasil perhitungan terlihat bahwa tebal pavement minimal adalah 88 cm. oleh sebab itu terdapat selisih tebal lapisan perkerasan hasil perhitungan dengan rencana sebesar 0.25 cm.
Hubungan Demografi Pegawai Dengan Penerapan Dinamika Pembelajaran (Studi Kasus: Kantor Syahbandar Dan Otoritas Pelabuhan Teluk Bayur)
Authors: Chairunissa Chairunissa
Published: February 2019

Tujuan penelitian ini untuk (1) mengetahui gambaran demografi pegawai dan rata-rata penerapan dinamika pembelajaran di KSOP Teluk Bayur; (2) mengetahui pengaruh faktor demografi pegawai terhadap penerapan dinamika pembelajaran di KSOP Teluk Bayur. Faktor demografi yang diamati adalah umur, jenis kelamin, tingkat pendidikan dan masa kerja, sedangkan variabel Dinamika Pembelajaran yang diamati adalah pembelajaran individu, kelompok, dan organisasi.Populasi dalam penelitian ini adalah pegawai administrasi KSOP Teluk Bayur.Pengambilan sampel pada penelitian ini dilakukan secara sensus.Metode analisis yang digunakan adalah univariat dan bivariat melalui uji probabilitas. Hasil pengujian pada penelitian ini adalah (1) Hasil rata-rata tingkat penerapan dinamika pembelajaran di KSOP Teluk Bayur 26,7 yang berarti Baik(2) Tidak terdapat pengaruh secara signifikan antara demografi pegawai terhadap penerapan dinamika pembelajaran di KSOP Teluk Bayur. Hal ini dibuktikan dari seluruh uji demografi pegawai menghasilkan nilai probabilitas > 0.05, maka Ho diterima. Kata kunci: demografi, dinamika pembelajaran, pegawai, KSOP Teluk Bayur.
Penelitian Fasilitas Bandar Udara Husein Sastranegara - Bandung
Authors: Najamuddin Ismail
Published: February 2019

Bandar Udara Husein Sastranegara Bandung dikelola oleh PT. Angkasa Pura II merupakan kawasan pangkalan Angkutan Udara TNI, Industri Dirgantara, Perguruan Tinggi Penerbangan, SekolahPenerbangan, Perkumpulan Aerosport mempunyai panjang landas pacu 2250 m x 45 m. Jumlah penumpang tahun 2012 sebesar 1.872.985 orang, sedangkan kemampuan bandara hanya 903.000 orang dan terjadi over capacity dengan perbandingan 2,1. Perhitungan fasilitas bandara mengacu SKEP 77/VI/ 2005 tentang Persyaratan Teknis Pengoperasian Fasilitas Teknik Bandar Udara dan peramalan penumpang menggunakan regresi berganda skenario moderat. Perluasan sisi darat gedung bandara menjadi 12.000 m2, fasilitas terminal lantai 1 dan lantai 2 sebesar 6000 m2. perluasan sisi udara hanya pada strip runway sedangkan panjang runway terbatas lahan karena ada obstacle kota dan gunung Bohong serta penataan tata letak taxiway dan apron dilakukan agar jarak parkir pesawat terhadap strip runway dan jarak wing tip to wing tip lebih aman dalam menampung 8 pesawat udara.
Pengaruh Sektor Transportasi Dan Perekonomian Provinsi Lampung
Authors: Yuliani Apri
Published: February 2019

Transportasi merupakan salah satu sektor lapangan usaha yang menjadi faktor pendukung kelancaran perekonomian Provinsi Lampung. Kajian ini bermaksud untuk mengetahui seberapa besar kontribusi transportasi terhadap kemajuan perekonomian Provinsi Lampung. Data yang dibutuhkan dalam kajian ini yaitu PDRB (Produk Domestik Regional Bruto) di sektor transportasi dan komunikasi; dan PDRB Propinsi Lampung. Alat analisis yang digunakan untuk mengetahui hubungan antara sektor transportasidan perekonomian Propinsi Lampung yaitu regresi linier.Berdasarkan PDRB Atas Dasar Harga Konstan Menurut Lapangan Usaha, sektor pengangkutan dan komunikasi mengalami pertumbuhan tertinggi hingga mencapai 13,63%.Sedangkan kontribusi sektor pengangkutan dan komunikasi terhadap PDRBsebesar 8,27%. Angkutan jalan merupakan angkutan dominan yang memiliki persentase sebesar 63,96% dari total PDRB di sektor pengangkutan. Berdasarkan hasil pengolahan data dengan menggunakan PDRB Atas Dasar Harga Konstan, disimpulkan adanya hubungan yang kuat antara sektor transportasi dan perekonomian Propinsi Lampung. Setiap adanya kenaikan Rp 1 di sektor transportasi, maka akan meningkatkan perekonomian Propinsi Lampung sampai dengan 13,09 kali. Selama tiga tahun terakhir struktur lapangan usaha masih didominasi oleh tiga sektor utama yaitu sektor pertanian, sektor perdagangan, hotel dan restoran dan sektor industri pengolahan. Keseluruhan sektor tersebut sangat bergantung kepada transportasi. Ketersediaan transportasi yang baik dapat meningkatkan kemajuan ekonomi di sembilan sektor lapangan usaha.
Implementasi Jaringan Saraf Tiruan Untuk Menentukan Kelayakan Proposal Tugas Akhir
Authors: Ayu Fitri
Published: February 2019

Sebuah Proposal Tugas Akhir (TA) yang diajukan mahasiswa harus diseleksi oleh Ketua Program Studi (KPS) untuk menentukan apakah proposal tersebut layak atau tidak untuk dilanjutkan sebagai salah satu syarat kelulusan, khususnya pada D3 Manajemen Informatika (MI) AMIK-ROYAL KISARAN. Proses penentuan kelayakan sebuah judul Tugas Akhir (TA) pada penelitian ini menerapkan konsep Jaringan Saraf Tiruan (JST) yang dibangun menggunakan enam kriteria sebagai input, antara lain : kesesuaian judul dengan visi Program Studi, implementasi program dalam penelitian, implementasi konsep jaringan dalam penelitian, sumber data yang digunakan, logis atau tidaknya suatu penelitian, memenuhi syarat untuk disebut sebagai sebuah sistem informasi. Ke-enam kriteria ini akan menjadi input bagi jaringan dalam melakukan pelatihan dan pengujian jaringan, dengan memvariasikan hidden layer yang digunakan. Dari penelitian yang dilakukan, dengan 40 data input di dapatkan bahwa jaringan akan memberikan hasil terbaik pada pembagian data 20x20 untuk pelatihan dan pengujian dengan pola 6-6-1, Dimana persentase tingkat kebenaran pada pelatihan adalah 90% dan pengujian 60% dengan α = 0,1. Dari hasil perbandingan perhitungan data antara Matlab dengan perhitungan manual diperolah tingkat kepercayaan 100%.
Synthetic bPNAs as Allosteric Triggers of Hammerhead Ribozyme Catalysis
Authors: Bong Dennis , Liang Yufeng , Mao Jie
Published: February 2019

The biochemistry and structural biology of the hammerhead ribozyme (HHR) has been well-elucidated. The secondary and tertiary structural elements that enable sugar-phosphate bond scission to be be catalyzed by this RNA are clearly understood. We have taken advantage of this knowledge base to test the extent to which synthetic molecules, may be used to trigger structure in secondary structure and tertiary interactions and thereby control HHR catalysis. These molecules belong to a family of molecules we call generally call “bPNAs” based on our work on bifacial peptide nucleic acid (bPNA). This family of molecules display the “bifacial” heterocycle melamine, which acts as a base-triple upon capturing two equivalents of thymine or uracil. Loosely structured internal oligouridylate bulges of 4-20 nucleotides can be restructured as triplex hybrid stems upon binding bPNAs. As such, a duplex stem element can be replaced with a bPNA triplex hybrid stem; similarly, a tertiary loop-stem interaction can be replaced with a loop-bPNA-stem complex. In this chapter, we discuss how bPNAs are prepared and applied to study structure-function turn-on in the hammerhead ribozyme system.
Mechanochemistry Enables Targeted Synthesis of Mixed-Metal Microporous Metal-Organic Frameworks Using Pre-Assembled Precursors
Authors: Ayoub Ghada , Karadeniz Bahar , Howarth Ashlee J. , Farha Omar , Đilović Ivica , Germann Luzia S. , Dinnebier Robert E. , Užarević Krunoslav , Friscic Tomislav
Published: February 2019

Ball milling mechanochemistry enables enables targeted, rapid synthesis of mixed-metal metal-organic frameworks (MOFs) with controllable stoichiometric composition. Specifically, the use of ball milling enabled the use of pre-assembled coordination polymers of zinc, magnesium, nickel(II) and cobalt(II) as precursors in an innovative mechanochemical strategy for the deliberate assembly of mixed-metal MOF-74 materials comprised of pairs of transition of main group metals in a pre-determinmed 1:1 stoichiometric ratio, including ZnMg-, ZnCo, ZnCu, MgZn-, MgCo-, MgCa-, NiZn-,NiMg-, NiCo-, CoZn-, CoMg- and CoCu-MOF-74. While this is the first example of target-oriented MOF synthesis using mechanochemistry, it also provides an entry to controlling the stoichiometric composition of mixed-metal frameworks.
Interactions Between the Aryldiazonium Cations and Graphene Oxide – a DFT Study
Authors: Berisha Avni
Published: February 2019

Understanding the grafting behavior of the aryldiazonium cations is of fundamental and also of practical importance for the vast number of applications that involve the use of modified Graphene oxide (from simple adsorption process to electronic and photovoltaic applications). In this work, the mechanism of the adsorption and grafting diazonium cations on the graphene oxide surface was investigated by the use of Density Functional Theory. Two types of aryldiazonium cations one bearing only phenyl ring and the other nitrophenyl were selected as adsorbates/grafted moiety. By evaluating the adsorption energies at 7 different positions onto the graphene oxide both in the gaseous and solvent phase (using COSMO approach) the most probable adsorption sites were found. Moreover, the most stable adsorption sites were used to calculate and plot NCI (Non-Covalent Interactions). The obtained results are important as they not only give molecular insights regarding the nature of the interaction and its dependence on the adsorption site of graphene oxide surface but also on the activation energy for such a grafting reaction to take place - providing a mechanistic aspect to understand these grafting reactions.