bluuebunny/crossref_metadata_2025 huggingface dataset:
Catalytic Conversion of Biomass Pyrolysis Vapours over Sodium‐Based Catalyst: A Study on the State of Sodium on the Catalyst
Authors: Nguyen Tang Son , Lefferts Leon , Sai Sankar Gupta Karthick Babu , Seshan Kulathuiyer
Published: June 2015

In situ upgrading of biomass pyrolysis vapours over Na2CO3/γ‐Al2O3 catalysts was studied in a laboratory‐scale fixed‐bed reactor at 500 °C. Catalytic oil exhibits a significant improvement over its non‐catalytic counterpart, such as lower oxygen content (12.3 wt % compared to 42.1 wt %), higher energy density (37.0 compared to 19.0 MJ kg−1) and lower acidity. A study using thermogravimetry–mass spectrometry analysis and 23Na and 1H magic‐angle spinning NMR techniques has revealed the formation of a new sodium species in the catalyst, which is responsible for the high catalytic activity. This species is proposed to be formed by the coordination of Na+ ions and the hydroxyl groups on the surface of γ‐Al2O3. Regeneration of the catalyst was performed in air at 600 °C and the regenerated material displays lower activity towards deoxygenation than the fresh catalyst. This deactivation is likely attributed to the change in the active sodium species during regeneration.
ChemInform Abstract: Theoretical Investigations of Novel Zinc Oxide Polytypes and In‐Depth Study of Their Electronic Properties.
Authors: Zagorac D. , Schoen J. C. , Zagorac J. , Jansen M.
Published: June 2015

Possible stable polytypes of ZnO are predicted using simulated annealing and threshold runs with an empirical potential followed by local minimization on ab initio level.
ChemInform Abstract: Synthesis, Crystal Structure, and Properties of the Sodium Molybdate Fluoride Na3MoO4F.
Authors: Zhang Xiangyu , Li Danni , Yang Zhihua , Wu Hongping , Pan Shilie
Published: June 2015

Single crystals of Na3MoO4F are obtained by solid state reaction of NaF, Na2CO3, and MoO3 (corundum crucible, 500 °C, 72 h).
ChemInform Abstract: Coexistence of Monochalocogen and Dichalocogen Ions in BiSe2 and BiS2 Crystals Prepared at High Pressure.
Authors: Yamamoto Ayako , Hashizume Daisuke , Bahramy Mohammad Saeed , Tokura Yoshinori
Published: June 2015

Single crystals of BiSe2 and BiS2 are prepared at 5.5 GPa (700—1100 °C) and characterized by single crystal XRD.
ChemInform Abstract: Synthesis and Photoluminescence Properties of the Red‐Emitting Phosphor Mg3(BN2)N Doped with Eu2+.
Authors: Schoelch Jessica , Dierkes Tobias , Enseling David , Stroebele Markus , Juestel Thomas , Meyer H.‐Juergen
Published: June 2015

Mg3(BN2)N is prepared by solid state metathesis reaction of a 3:1:2 molar mixture of MgCl2, Mg3N2, and Li3BN2 (evacuated silica tube, 700 °C, 1 d).
ChemInform Abstract: Selective Reversible Hydrogenation of Mg(B3H8)2/MgH2 to Mg(BH4)2: Pathway to Reversible Borane‐Based Hydrogen Storage?
Authors: Chong Marina , Matsuo Motoaki , Orimo Shin‐ichi , Autrey Tom , Jensen Craig M.
Published: June 2015

Reversible hydrogenation of Mg(B3H8)2·2THF (obtained by addition of BH3·THF to Mg/Hg amalgam) is investigated in the presence of MgH2, LiH, or NaH.
ChemInform Abstract: Tellurium Sulfates from Reactions in Oleum and Sulfur Trioxide: Syntheses and Crystal Structures of TeO(SO4), Te4O3(SO4)5, and Te(S2O7)2.
Authors: Logemann Christian , Bruns Joern , Schindler Lisa Verena , Zimmermann Vanessa , Wickleder Mathias S.
Published: June 2015

TeO(SO4) is prepared by reaction of K2TeO4 with oleum (65% SO3) (evacuated glass ampoules, 250 °C, 1 d).
ChemInform Abstract: Macroscopic Polarity Control with Alkali Metal Cation Size and Coordination Environment in a Series of Tin Iodates.
Authors: Kim Yeong Hun , Tran T. Thao , Halasyamani P. Shiv , Ok Kang Min
Published: June 2015

Single crystals of (IIIa—e) and (V) are hydrothermally grown and characterized by single crystal XRD, IR and UV/VIS spectroscopy, SEM, second harmonic generation measurements, and piezoelectric and polarization measurements.
ChemInform Abstract: Pb7O(OH)3(CO3)3(BO3): First Mixed Borate and Carbonate Nonlinear Optical Material Exhibiting Large Second‐Harmonic Generation Response.
Authors: Abudoureheman Maierhaba , Wang Li , Zhang Xianming , Yu Hongwei , Yang Zhihua , Lei Chen , Han Jian , Pan Shilie
Published: June 2015

The title UV nonlinear optical material is hydrothermally synthesized from Pb(NO3)2, H3BO3, Cs2CO3, and KOH in the molar ratio 1:4:1:10 (autoclave, 180 °C, 12 h, 75% yield).
ChemInform Abstract: Mo2Ga2C: A New Ternary Nanolaminated Carbide.
Authors: Rosen J. , et al.
Published: June 2015

The new hexagonal title phase is prepared by heating a 2:1 Mo/C powder mixture in flowing Ar at 1000 °C for 12 h.
ChemInform Abstract: Synthesis, Crystal Structure and Catalytic Activity of the Guanidinium Cation Directed Nickel(II)‐Containing Open Wells—Dawson 19‐Tungstodiarsenate(III) [{Ni(H2O)4}2{Na (H2O)}As2W19O67(H2O)] 9‐.
Authors: Saini Mukesh Kumar , Gupta Rakesh , Singh Surendra , Hussain Firasat
Published: June 2015

The open Wells—Dawson type compound [C(NH2)3]5Na4 [{Ni(H2O)4}2{Na(H2O)} As2W19O67(H2O)] 9‐·22 H2O is obtained from an aqueous mixture of NiCl2, Py‐2,6‐CO2H (80 °C, 1 h), and trilacunary Na9[α‐AsW9O33] which is added prior to guanidinium chloride at pH 5.8 as the structure directing cation (2‐3 weeks, 46% yield).
ChemInform Abstract: Preparation of Carbon Supported CuPd Nanoparticles as Novel Heterogeneous Catalysts for the Reduction of Nitroarenes and the Phosphine‐Free Suzuki—Miyaura Coupling Reaction.
Authors: Nasrollahzadeh Mahmoud , Jaleh Babak , Ehsani Ali
Published: June 2015

Carbon‐supported bimetallic CuPd nanoparticles are shown to be an efficient catalyst for the reduction of nitrorarenes and for the phosphine‐free Suzuki—Miyaura coupling reaction.
ChemInform Abstract: Chiral Calcium‐BINOL Phosphate Catalyzed Diastereo‐ and Enantioselective Synthesis of syn‐1,2‐Disubstituted 1,2‐Diamines: Scope and Mechanistic Studies.
Authors: Lalli Claudia , Dumoulin Audrey , Lebee Clement , Drouet Fleur , Guerineau Vincent , Touboul David , Gandon Vincent , Zhu Jieping , Masson Geraldine
Published: June 2015

Spectroscopic investigations reveal that the catalyst exists in various oligomeric forms.
ChemInform Abstract: Design of a Chiral Secondary Amine Ligand for Copper‐Catalyzed anti‐Selective Henry Reaction.
Authors: Arai Takayoshi , Joko Akinori , Sato Katsuya
Published: June 2015

The N‐monobenzyl (S)‐binap‐(R,R)‐dpen ligand (CBL) containing a secondary amine moiety promotes the Cu(OAc)2‐catalyzed Henry reaction with excellent enantioselectivity in an anti‐selective fashion.
ChemInform Abstract: Asymmetric Transfer Hydrogenation Reaction in Water: Comparison of Chiral Proline Amide/Amine Ruthenium(II) Complexes.
Authors: Denizalti Serpil , Mercan Deniz , Sen Betuel , Goekce Aytac Guerhan , Cetinkaya Bekir
Published: June 2015

Chiral proline amide/amine ligands are synthesized and applied in the asymmetric transfer hydrogenation of aromatic ketones such as (I) and (III).
ChemInform Abstract: Divergent Phosphine‐Catalyzed [2 + 4] or [3 + 2] Cycloaddition Reactions of γ‐Substituted Allenoates with Oxadienes.
Authors: Li Erqing , Chang Meijia , Liang Ling , Huang You
Published: June 2015

Depending on the reaction conditions including different catalysts, formation of either dihydropyrans or multifunctionalized cyclopentenes takes place.
ChemInform Abstract: Biaryl Synthesis by Ring‐Opening Friedel—Crafts Arylation of 1,4‐Epoxy‐1,4‐dihydronaphthalenes Catalyzed by Iron Trichloride.
Authors: Sawama Yoshinari , Asai Shota , Kawajiri Takahiro , Monguchi Yasunari , Sajiki Hironao
Published: June 2015

A highly regioselective iron‐catalyzed Friedel—Crafts Arylation of 1,4‐epoxy‐1,4‐dihydronaphthalenes is presented.
ChemInform Abstract: Asymmetric Hydrogenation of Furans and Benzofurans with Iridium—Pyridine—Phosphinite Catalysts.
Authors: Pauli Larissa , Tannert Rene , Scheil Robin , Pfaltz Andreas
Published: June 2015

Excellent enantioselectivities and high conversions are achieved for 3‐substituted furans (I) and 2‐substituted benzofurans (VII).
ChemInform Abstract: Metal‐Mediated Reformatsky Reaction of Bromodifluoromethyl Ketone and Imine.
Authors: Cao Chun‐Ru , Jiang Min , Liu Jin‐Tao
Published: June 2015

The Reformatsky reaction of bromodifluoromethyl ketones and imines took place readily in the presence of Zn/CuBr at room temperature to afford β‐amino α,α‐difluoro ketones in good yields.
ChemInform Abstract: Matsuda—Heck Reaction with Arenediazonium Tosylates in Water.
Authors: Kutonova Ksenia V. , Trusova Marina E. , Stankevich Andrey V. , Postnikov Pavel S. , Filimonov Victor D.
Published: June 2015

The reaction is conducted under environmentally benign conditions.
ChemInform Abstract: Catalytic Organic Reactions on the Surface of Silver(I) Oxide in Water.
Authors: Ueno Masaharu , Tanoue Arata , Kobayashi Shu
Published: June 2015

A method for the Ag2O‐catalyzed allylation of aldehydes in water is presented.
ChemInform Abstract: A Practical, Catalytic and Selective Deprotection of a Boc Group in N,N′‐Diprotected Amines Using Iron(III)‐Catalysis.
Authors: Lopez‐Soria Juan M. , Perez Sixto J. , Hernandez J. Nicolas , Ramirez Miguel A. , Martin Victor S. , Padron Juan I.
Published: June 2015

Various N,N′‐diprotected amino acids and amine derivatives are selectively deprotected from the Boc‐group.
ChemInform Abstract: Chemoselective Chromium(II)‐Catalyzed Cross‐Coupling Reactions of Dichlorinated Heteroaromatics with Functionalized Aryl Grignard Reagents.
Authors: Steib Andreas K. , Kuzmina Olesya M. , Fernandez Sarah , Malhotra Sushant , Knochel Paul
Published: June 2015

The regioselective α‐arylation of α‐chloropyridines and quinoline is catalyzed by CrCl2.
ChemInform Abstract: Acetyl Cyanide as a Cyanide Source in a Tandem Catalyst‐Free Modified Groebke—Blackburn—Bienayme [4 + 1]‐Cycloaddition‐Strecker Cascade.
Authors: Martinez‐Ariza Guillermo , Nunez‐Rios Jose , Lee Yeon‐Sun , Hulme Christopher
Published: June 2015

The operationally simple one‐pot three‐step cascade reaction allows the synthesis of biologically significant imidazoheterocycles in short reaction times.
ChemInform Abstract: Double Heteroatom Functionalization of Arenes Using Benzyne Three‐Component Coupling.
Authors: Garcia‐Lopez Jose‐Antonio , Cetin Meliha , Greaney Michael F.
Published: June 2015

A new, one‐pot approach to double heteroatom‐substituted arenes with combinations such as N,N, S,N, Se,N, S,S, S,P, and N,P (no example shown) is developed.
ChemInform Abstract: Practical Synthesis of [n]Cycloparaphenylenes (n = 5, 7—12) by H2SnCl4‐Mediated Aromatization of 1,4‐Dihydroxycyclo‐2,5‐diene Precursors.
Authors: Patel Vijay Kumar , Kayahara Eiichi , Yamago Shigeru
Published: June 2015

Title compounds containing dihydroxycyclohexadiendiyl units are prepared by a modified synthetic method developed by Jasti and co‐workers for the synthesis of corresponding dimethoxy derivatives.
ChemInform Abstract: Sodium Iodide‐Catalyzed Direct α‐Alkoxylation of Ketones with Alcohols via Oxidation of α‐Iodo Ketone Intermediates.
Authors: Zhu Cuiju , Zhang Yuanfei , Zhao Huaiqing , Huang Shijun , Zhang Min , Su Weiping
Published: June 2015

α‐Iodo ketones are the key reaction intermediates which are converted into α‐alkoxylated ketones via further oxidation to hypervalent iodine species rather than nucleophilic substitution.
ChemInform Abstract: Highly Regio‐ and Enantioselective Synthesis of γ,δ‐Unsaturated Amido Esters by Catalytic Hydrogenation of Conjugated Enamides.
Authors: Gao Min , Meng Jing‐jing , Lv Hui , Zhang Xumu
Published: June 2015

The title reaction proceeds in the presence of a Rh/TangPhos catalyst system giving a series of γ,δ‐unsaturated amido esters in excellent yields and enantioselectivities.
ChemInform Abstract: Asymmetric α‐Benzoyloxylation of β‐Ketocarbonyls by a Chiral Primary Amine Catalyst.
Authors: Wang Dehong , Xu Changming , Zhang Long , Luo Sanzhong
Published: June 2015

The scalable reaction procedure allows a highly enantioselective transformation of cyclic and acyclic 1,3‐diketones, β‐ketoesters and amides to the corresponding α‐benzyloxylated and α‐aryloxylated products.
ChemInform Abstract: Rhodium(I)‐Catalyzed Cycloisomerization of Allene‐Allenylcyclopropanes.
Authors: Kawamura Takamasa , Kawaguchi Yasuaki , Sugikubo Katsuya , Inagaki Fuyuhiko , Mukai Chisato
Published: June 2015

Under conditions A), substrates bearing electron‐deficient substituents at both allenyl sites produce a bicyclo[5.3.0]deca‐1,6,8‐triene skeleton with incorporation of the cyclopropane moiety as C1‐building block and concomitant elimination of ethylene.
ChemInform Abstract: Nonafluorobutanesulfonyl Azide as a Shelf‐Stable Highly Reactive Oxidant for the Copper‐Catalyzed Synthesis of 1,3‐Diynes from Terminal Alkynes.
Authors: Suarez Jose Ramon , Collado‐Sanz Daniel , Cardenas Diego J. , Chiara Jose Luis
Published: June 2015

In the presence of NFA, the process is finished after 10 min with good to excellent yields.
ChemInform Abstract: PhenoFluorMix: Practical Chemoselective Deoxyfluorination of Phenols.
Authors: Fujimoto Teppei , Ritter Tobias
Published: June 2015

The novel reagent PhenoFluorMix is applied to the scalable deoxyfluorination of various phenols and hetaromatic derivatives thereof as well as of natural products such as steroids and hydroxycinchonidines.
ChemInform Abstract: Myoglobin‐Catalyzed Intermolecular Carbene N—H Insertion with Arylamine Substrates.
Authors: Sreenilayam Gopeekrishnan , Fasan Rudi
Published: June 2015

It is demonstrated, that an engineered variant of myoglobin efficiently promotes the insertion of α‐diazo esters into C‐H bonds of anilines.
ChemInform Abstract: Ligand‐Promoted ortho‐C—H Amination with Pd Catalysts.
Authors: Zhu Dajian , Yang Guoqiang , He Jian , Chu Ling , Chen Gang , Gong Wei , Chen Ke , Eastgate Martin D. , Yu Jin‐Quan
Published: June 2015

2,4,6‐Trimethoxypyridine is identified as an efficient ligand for promoting a Pd‐catalyzed ortho‐C—H amination of both benzamides and triflyl‐protected benzylamines.
ChemInform Abstract: Convenient and Direct Azidation of sec‐Benzyl Alcohols by Trimethylsilyl Azide with Bismuth(III) Triflate Catalyst.
Authors: Tummatorn Jumreang , Thongsornkleeb Charnsak , Ruchirawat Somsak , Thongaram Phanida , Kaewmee Benyapa
Published: June 2015

This direct azidation process provides secondary and tertiary benzyl azides in high yields and short reaction times, whereas primary benzyl alcohol (Ig) fails to react.
ChemInform Abstract: Investigation of Alkyne Regioselectivity in the Ni‐Catalyzed Benzannulation of Cyclobutenones.
Authors: Stalling Timo , Harker Wesley R. R. , Auvinet Anne‐Laure , Cornel Erik J. , Harrity Joseph P. A.
Published: June 2015

In general, the title reaction proceeds with low levels of regioselectivity.
ChemInform Abstract: Aziridinylethers as Highly Enantioselective Ligands for the Asymmetric Addition of Organozinc Species to Carbonyl Compounds.
Authors: Pieczonka Adam M. , Lesniak Stanislaw , Jarzynski Szymon , Rachwalski Michal
Published: June 2015

New chiral aziridinylether ligands are synthesized.
ChemInform Abstract: Highly Enantioselective, Intermolecular Hydroamination of Allenyl Esters Catalyzed by Bifunctional Phosphinothioureas.
Authors: Fang Yuan‐Qing , Tadross Pamela M. , Jacobsen Eric N.
Published: June 2015

A highly regio‐ and enantioselective γ‐hydroamination of allenyl and propargyl esters with N‐methoxy carbamate nucleophiles is developed to yield α,β‐unsaturated γ‐amino acid esters products.
ChemInform Abstract: Cu‐Catalyzed Aerobic Oxidative Esterification of Acetophenones with Alcohols to α‐Ketoesters.
Authors: Xu Xuezhao , Ding Wen , Lin Yuanguang , Song Qiuling
Published: June 2015

The reaction of various aryl and hetarylmethylketones with aliphatic and benzylic alcohols as well as arylethyl alcohol derivatives or even cholesterol to α‐ketoesters is described.
ChemInform Abstract: The Oxidative Cross‐Coupling of Benzonitriles with Multiform Substrates: A Domino Strategy Inspired Easy Access to α‐Ketoimides.
Authors: Kalmode Hanuman P. , Vadagaonkar Kamlesh S. , Chaskar Atul C.
Published: June 2015

Vinylarenes, alkynylarenes, or 1‐arylethanols react with benzonitriles in the presence of iodine and DMSO to form α‐ketoimides.
ChemInform Abstract: N,N‐Diethylurea‐Catalyzed Amidation Between Electron‐Deficient Aryl Azides and Phenylacetaldehydes.
Authors: Xie Sheng , Ramstroem Olof , Yan Mingdi
Published: June 2015

The urea catalyst activates the aldehydes and stabilizes the enol form, which reacts further with the azides to give amides (III) and (V) in a cycloaddition/nitrogen extrusion/1,5‐hydride shift sequence.
ChemInform Abstract: Stereoselective Mannich Reaction of S‐Phenyl Thioesters Catalyzed by Bifunctional Organocatalysts.
Authors: Guang Jie , Larson Ariel J. , Zhao John C.‐G.
Published: June 2015

S‐phenylthioesters undergo an efficient stereoselective addition reaction to N‐Tosylaldimines in the presence of a bifunctional organocatalyst.
ChemInform Abstract: [2,3] Sigmatropic Rearrangement of Propargylic Sulfinates by a Pale Ag1‐USY Zeolite and Silver Salts.
Authors: Hampton Carissa S. , Harmata Michael
Published: June 2015

The applied catalyst (zeolite Ag‐USY) can be recycled several times and therefore this reaction becomes “greener”.
ChemInform Abstract: Pd‐Catalyzed Direct C—H Bond Sulfonylation of Azobenzenes with Arylsulfonyl Chlorides.
Authors: Zhang Duo , Cui Xiuling , Zhang Qianqian , Wu Yangjie
Published: June 2015

The ortho‐directed Pd(II)‐catalyzed C—H sulfonylation of azobenzenes with arylsulfonyl chlorides using potassium peroxodisulfate as the oxidant gives selective sulfonylation ortho to the azo‐substituent.
ChemInform Abstract: Copper‐Catalyzed Cross Dehydrogenative Coupling of N,N‐Disubstituted Formamides and Phenols: A Direct Access to Carbamates.
Authors: Ali Wajid , Rout Saroj K. , Guin Srimanta , Modi Anju , Banerjee Arghya , Patel Bhisma K.
Published: June 2015

An efficient process for the oxidative coupling of a variety of phenols having an ortho‐benzothiazole substituent, 8‐hydroxyquinoline and ortho‐formyl phenols with N,N‐dialkylformamides using tBuOOH as the oxidant in the presence of a Cu(II)‐catalyst is presented.
ChemInform Abstract: Synthesis of Unsymmetrical Phenylurea Derivatives via Oxidative Cross Coupling of Aryl Formamides with Amines under Metal‐Free Conditions.
Authors: Reddy Nagireddy Veera , Kumar Pailla Santhosh , Reddy Peddi Sudhir , Kantam Mannepalli Lakshmi , Reddy Kallu Rajender
Published: June 2015

Arylurea derivatives are prepared by the cross coupling of N‐aryl formamides with amines via the formation of isocyanate intermediates in the presence of the hypervalent [bis(trifluoroacetoxy)iodo]benzene as oxidant.
ChemInform Abstract: Tuning Reactivity and Site Selectivity of Simple Arenes in C—H Activation: ortho‐Arylation of Anisoles via Arene—Metal π‐Complexation.
Authors: Ricci Paolo , Kraemer Katrina , Larrosa Igor
Published: June 2015

An unprecedented easy ortho‐selective arylation of anisoles is reported.
ChemInform Abstract: Oxidative Radical 1,2‐Alkylarylation of Alkenes with α‐C(sp3)—H Bonds of Acetonitriles Involving 1,2‐Aryl Migration.
Authors: Li Yang , Liu Bang , Li Hai‐Bing , Wang Qiuan , Li Jin‐Heng
Published: June 2015

The reaction proceeds through a metal‐free oxidative alkene 1,2‐alkylarylation.
ChemInform Abstract: Organocatalytic Asymmetric Hydroarylation of O‐Hydroxyl Styrenes via Remote Activation of Phenylhydrazones.
Authors: Dai Wei , Lu Han , Jiang Xiao‐Li , Gao Ting‐Ting , Shi Feng
Published: June 2015

The first catalytic asymmetric styrene hydroarylation results via the enantioselective Friedel—Crafts alkylation of phenylhydrazones with o‐hydroxyl styrenes using chiral phosphoric acid as catalysts to give chiral 1,1‐diarylethanes with high enantioselectivity.
ChemInform Abstract: Ethylaluminum as an Ethylene Source for the Mizoroki—Heck‐Type Reaction. Rhodium‐Catalyzed Preparation of Stilbene Derivatives.
Authors: Tanaka Shota , Itami Kazuki , Sunahara Kazuhiro , Tatsuta Go , Mori Atsunori
Published: June 2015

The reaction also performs well with aryl‐ and ethyl‐Grignards (V) and (VI) in the presence of AlCl3.
ChemInform Abstract: Pd‐Catalyzed Three‐Component Coupling of Terminal Alkynes, Arynes, and Vinyl Cyclopropane Dicarboxylate.
Authors: Garve Lennart K. B. , Werz Daniel B.
Published: June 2015

The efficient protocol provides access to 1‐allyl‐2‐alkynylbenzenes.
ChemInform Abstract: tert‐Butyl Esters of Peptides as Organocatalysts for the Asymmetric Aldol Reaction.
Authors: Bisticha Aikaterini , Triandafillidi Ierasia , Kokotos Christoforos G.
Published: June 2015

Several tert‐butyl esters of peptides are prepared.
ChemInform Abstract: Rhodium‐Catalyzed Desulfination of Sodium Arenesulfinates and Oxidative Annulation with Alkynes.
Authors: Wang Hui , Wang Yuyuan , Yang Haijun , Tan Chunyan , Jiang Yuyang , Zhao Yufen , Fu Hua
Published: June 2015

A convenient protocol for the sequential desulfination of arenesulfinates, addition of the resulting aryl‐Rh(II) complexes to alkynes followed by intramolecular oxidative annulation.
ChemInform Abstract: Catalyst‐Free Synthesis of Spiropyrazolines from Chalcones and Cyclic Ketone N‐Tosylhydrazones.
Authors: Wu Qin‐Xi , Li Hui‐Jing , Wang Hong‐Shuang , Zhang Zhen‐Guo , Wang Chen‐Chao , Wu Yan‐Chao
Published: June 2015

The title compounds are efficiently obtained with high selectivity and functional‐group tolerance from readily available and stable starting materials.
ChemInform Abstract: Iron Catalyzed Cross‐Couplings of Azetidines — Application to the Formal Synthesis of a Pharmacologically Active Molecule.
Authors: Parmar Dixit , Henkel Lena , Dib Josef , Rueping Magnus
Published: June 2015

A protocol for the coupling of 3‐iodoazetidine (I) with Grignard reagents (II) in the presence of a Fe‐catalyst is described.
ChemInform Abstract: An Efficient Nanoparticle‐Supported and Magnetically Recoverable Copper(I) Catalyst for Synthesis of Furans from Ene‐Yne‐Ketone.
Authors: Liu Yi , Liu Zhan , Cui Yingde
Published: June 2015

The employed catalyst can be easily recovered from the reaction by external magnets and reused eight times without significant loss of its catalytic activity.
ChemInform Abstract: Metal‐Free Reagent Dependent S—S and C—C Homocoupling of α‐Enolic Dithioesters at Room Temperature: Direct Access to Fully Substituted Symmetrical Thiophenes via Chemoselective Paal—Knorr Approach.
Authors: Ramulu B. Janaki , Nagaraju Anugula , Chowdhury Sushobhan , Koley Suvajit , Singh Maya Shankar
Published: June 2015

The oxidative dimerization of α‐enolic dithioesters (I) is investigated.
ChemInform Abstract: Diastereoselective Synthesis of Propargylic N‐Hydroxylamines via NHC—Copper(I) Halide‐Catalyzed Reaction of Terminal Alkynes with Chiral Nitrones on Water.
Authors: Wozniak L. , Staszewska‐Krajewska O. , Michalak M.
Published: June 2015

The methodology is applied as key step in the synthesis of (‐)‐lentiginosine (XV).
ChemInform Abstract: From Anilines to Isatins: Oxidative Palladium‐Catalyzed Double Carbonylation of C—H Bonds.
Authors: Li Wu , Duan Zhengli , Zhang Xueye , Zhang Heng , Wang Mengfan , Jiang Ru , Zeng Hongyao , Liu Chao , Lei Aiwen
Published: June 2015

A novel palladium‐catalyzed C—H double carbonylation introduces two adjacent carbonyl groups for the synthesis of isatins from readily available anilines.
ChemInform Abstract: Synthesis of 3‐Fluoro‐2‐hetarylindoles and 3,3‐Difluoro‐2‐hetarylindolines Through Lewis Acid‐Catalyzed Formation of 3,3‐Difluoroindolium Ions.
Authors: Fong Jacqueline Zi Mei , Choo Simon Sze Shiong , Richard Jean‐Alexandre , Garland Marc V. , Guo Liangfeng , Johannes Charles W. , Nguyen Tuan Minh
Published: June 2015

The synthesis of various 3‐fluoro‐2‐hetarylindoles through addition of indoles, pyrroles, or alkyl‐substituted furans to 3,3‐difluoroindolium ions generated in situ by zinc triflate‐catalyzed oxazolidine ring opening is described.
ChemInform Abstract: Metal‐Free Nitrative Cyclization of N‐Aryl Imines with tert‐Butyl Nitrite: Dehydrogenative Access to 3‐Nitroindoles.
Authors: Deng Guo‐Bo , Zhang Jia‐Ling , Liu Yan‐Yun , Liu Bang , Yang Xu‐Heng , Li Jin‐Heng
Published: June 2015

The cyclization works well with tert‐butyl nitrite only while similar reagents iso‐butyl or n‐amyl nitrite give preferentially β‐nitroethylidene derivatives, e.
ChemInform Abstract: Palladium‐Catalyzed Diastereoselective Oxyarylation of 2‐Alkylindoles.
Authors: Ramella Vincenzo , He Zhiheng , Daniliuc Constantin G. , Studer Armido
Published: June 2015

The title reaction uses commercially available boronic acids (II) as the aryl source and TEMPO as the oxidant and gives N‐protected (2‐chloroacetoxy)indolines in good yields with good to excellent diastereoselectivities.
ChemInform Abstract: tert‐Butyl Hypochlorite Mediated Diastereoselective Oxidative Coupling: Access to 1‐Functionalized Tetrahydrocarbazoles.
Authors: Jiang Long , Xie Xiaoni , Zu Liansuo
Published: June 2015

A mild and simple method for the direct C‐H functionalization of the C‐1 position of tetrahydrocarbazoles with good functional group tolerance is presented.
ChemInform Abstract: Bifunctional One‐Component Catalysts for the Addition of Carbon Dioxide to Epoxides.
Authors: Buettner Hendrik , Lau Kornelia , Spannenberg Anke , Werner Thomas
Published: June 2015

An efficient synthesis of cyclic carbonates including the naturally occurring carbonate (VII) is presented by using the iodide organocatalyst.
ChemInform Abstract: A Highly Regio‐ and Stereoselective Synthesis of α‐Fluorinated Imides via Fluorination of Chiral Enamides.
Authors: Xu Yan‐Shuang , Tang Yu , Feng He‐Jing , Liu Ji‐Tian , Hsung Richard P.
Published: June 2015

Enamides equipped with a chiral Evans auxiliary react with N‐fluorobenzenesulfonimide to form N,O‐hemiacetals.
ChemInform Abstract: Rhodium‐Catalyzed Asymmetric Arylation of Cyclic N‐Sulfonyl Aryl Alkyl Ketimines: Efficient Access to Highly Enantioenriched α‐Tertiary Amines.
Authors: Jiang Tao , Wang Zheng , Xu Ming‐Hua
Published: June 2015

The method provides a highly enantioselective access to chiral α‐arylalkyl‐substituted benzosultams and benzosulfamidates.
ChemInform Abstract: Halide Inhibition of the Copper‐Catalyzed Azide—Alkyne Cycloaddition.
Authors: Moorman Rebekah M. , Collier Matthew B. , Frohock Bram H. , Womble Michael D. , Chalker Justin M.
Published: June 2015

The effect of halide anions on rate and yield of the model click reaction between ethyl azidoacetate and phenylacetylene is studied.
ChemInform Abstract: Facile Synthesis of 5‐Substituted 1H‐Tetrazoles Catalyzed by Tetrabutylammonium Hydrogen Sulfate in Water.
Authors: Wang Zengtao , Liu Zhiguo , Cheon Seung Hoon
Published: June 2015

The introduced procedure is environmentally‐friendly, practical, and provides excellent yields of tetrazoles (II).
ChemInform Abstract: Control of Five Contiguous Stereogenic Centers in an Organocatalytic Kinetic Resolution via Michael/Acetalization Sequence: Synthesis of Fully Substituted Tetrahydropyranols.
Authors: Gurubrahamam Ramani , Cheng You‐Song , Chen Kwunmin
Published: June 2015

The conversion of aldehydes with a range of aryl substituted secondary nitroallylic alcohols in the presence of a chiral prolinol derivative furnishes the title products with excellent stereoselectivities.
ChemInform Abstract: Directing Group Assisted Nucleophilic Substitution of Propargylic Alcohols via o‐Quinone Methide Intermediates: Broensted Acid Catalyzed, Highly Enantio‐ and Diastereoselective Synthesis of 7‐Alkynyl‐12a‐acetamido‐Substituted Benzoxanthenes.
Authors: Saha Satyajit , Schneider Christoph
Published: June 2015

The title reaction is catalyzed by a BINOL‐based, chiral phosphoric acid.
ChemInform Abstract: Broensted Acid‐Catalyzed, Highly Enantioselective Addition of Enamides to in situ‐Generated ortho‐Quinone Methides: A Domino Approach to Complex Acetamidotetrahydroxanthenes.
Authors: Saha Satyajit , Schneider Christoph
Published: June 2015

A chiral BINOL‐based phosphoric acid catalyst is found to control efficiently the enantioselectivity of the C—C bond forming process.
ChemInform Abstract: Highly Regio‐ and Enantioselective Synthesis of N‐Substituted 2‐Pyridones: Iridium‐Catalyzed Intermolecular Asymmetric Allylic Amination.
Authors: Zhang Xiao , Yang Ze‐Peng , Huang Lin , You Shu‐Li
Published: June 2015

The Ir‐catalyzed asymmetric allylic amination of 2‐hydroxypyridines with allyl methyl carbonates (II) is reported for the first time.
ChemInform Abstract: Cu‐Catalyzed Concise Synthesis of Pyridines and 2‐(1H)‐Pyridones from Acetaldehydes and Simple Nitrogen Donors.
Authors: Li Ziyuan , Huang Xiaoqiang , Chen Feng , Zhang Chun , Wang Xiaoyang , Jiao Ning
Published: June 2015

3,5‐Diarylpyridines, 3,5‐diaryl‐2‐ketopyridines and 3,5‐(het)aryl‐2‐(1H)‐pyridones are prepared using ammonium ceric nitrate, trimethylsilyl azide or 2‐aminopyridine as efficient nitrogen donors, respectively.
ChemInform Abstract: Palladium‐Catalyzed [4 + 2] Cycloaddition of Aldimines and 1,4‐Dipolar Equivalents via Amphiphilic Allylation.
Authors: Hirata Goki , Yamada Naoshi , Sanada Shohei , Onodera Gen , Kimura Masanari
Published: June 2015

The title reaction is promoted by diethylzinc.
ChemInform Abstract: Metal‐Free Ring Expansion of Indoles with Nitroalkenes: A Simple, Modular Approach to 3‐Substituted 2‐Quinolones.
Authors: Aksenov Alexander V. , Smirnov Alexander N. , Aksenov Nicolai A. , Aksenova Inna V. , Matheny Jonathon P. , Rubin Michael
Published: June 2015

The title compounds are obtained by a novel acid‐mediated cascade transformation via the ANRORC (addition of nucleophile, ring opening, and ring closure) mechanism.
ChemInform Abstract: Highly Selective Synthesis of Functionalized Polyhydroisoquinoline Derivatives via a Three‐Component Domino Reaction.
Authors: Feng Xian , Wang Jian‐Jun , Xun Zhan , Zhang Juan‐Juan , Huang Zhi‐Bin , Shi Da‐Qing
Published: June 2015

A convenient microwave promoted three‐component domino reaction of β‐ketoamides (I), pentandial (II), and malononitrile (III) is developed to give deca‐ and octahydroisoquinolines (IV) and (VI).
ChemInform Abstract: Intramolecular Cycloadditions of Photogenerated Azaxylylenes with Oxadiazoles Provide Direct Access to Versatile Polyheterocyclic Ketopiperazines Containing a Spiro‐Oxirane Moiety.
Authors: Kumar N. N. Bhuvan , Kuznetsov Dmitry M. , Kutateladze Andrei G.
Published: June 2015

The photogenerated diketopiperazinoquinolinol products (II) contain a reactive oxirane moiety which proves synthetically useful for further transformations.
ChemInform Abstract: Synthesis of 4,6‐Unsubstituted 2‐Aminodihydropyrimidine‐5‐carboxylates Through Sequential Staudinger/Aza‐Wittig/Cyclization Reactions.
Authors: Nishimura Yoshio , Cho Hidetsura
Published: June 2015

The one‐pot synthesis of the title compounds (III) proceeds in high overall yield.
ChemInform Abstract: Efficient Synthesis of 2‐Methylenethiazolo[2,3‐b]quinazolinone Derivatives.
Authors: Mahdavi Mohammad , Bialam Maryam , Saeedi Mina , Jafarpour Farnaz , Foroumadi Alireza , Shafiee Abbas
Published: June 2015

by KOH‐reaction of substituted o‐amino‐N‐(prop‐2‐yn‐1‐yl) aromatic amides (I) with CS2
ChemInform Abstract: Integrated One‐Flow Synthesis of Heterocyclic Thioquinazolinones Through Serial Microreactions with Two Organolithium Intermediates.
Authors: Kim Heejin , Lee Hyune‐Jea , Kim Dong‐Pyo
Published: June 2015

A three‐step reaction consisting of bromine‐lithium exchange at the isothiocyanate (I), reaction of the resulting aryllithium reagent with arylisocyanates, and a final S‐benzylation with benzyl bromides is carried out in a continuous‐flow integrated microfluidic reactor to give thioquinazolines (IV).
ChemInform Abstract: Iodine‐Mediated Synthesis of Indazolo‐Quinazolinones via a Multi‐Component Reaction.
Authors: Palaniraja Jeyakannu , Roopan Selvaraj Mohana
Published: June 2015

An efficient and simple method for the synthesis of indazolo‐quinazolinone fused ring systems by multi‐component reaction involving an in situ generation of the 1H‐indazol‐3‐amine derivative in ethanol followed by its reaction with diketone and various arylaldehydes in acetonitrile is developed.
ChemInform Abstract: Potassium Iodide‐Catalyzed Three‐Component Synthesis of 2‐Arylquinazolines via Amination of Benzylic C—H Bonds of Methylarenes.
Authors: Zhao Dan , Shen Qi , Li Jian‐Xin
Published: June 2015

Commonly used ammonia salt and the sp3 carbon in methylarenes are utilized as nitrogen and C1 sources to establish a novel potassium iodide‐catalyzed three‐component synthesis of quinazolines in which an aryl aldehyde is involved as a key intermediate.
ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Highly Enantioselective Friedel—Crafts Alkylation Reaction of C3‐Substituted Indoles to β,γ‐Unsaturated α‐Ketimino Esters.
Authors: Bi Bo , Lou Qin‐Xin , Ding Yu‐Yang , Chen Sheng‐Wei , Zhang Sha‐Sha , Hu Wen‐Hui , Zhao Jun‐Ling
Published: June 2015

The scalable reaction allows the preparation of C2‐substituted indole derivatives bearing an α‐ketimino ester motif in moderate to high yields.
ChemInform Abstract: Synthesis of Enaminones and Their Difluoroboron Complexes Through Domino Aryl Migration.
Authors: Yang Zheng , Jiang Bo , Hao Wen‐Juan , Zhou Peng , Tu Shu‐Jiang , Li Guigen
Published: June 2015

This new domino strategy allows the selective synthesis of boron complexes.
ChemInform Abstract: endo‐Selective Pd‐Catalyzed Silyl Methyl Heck Reaction.
Authors: Parasram Marvin , Iaroshenko Viktor O. , Gevorgyan Vladimir
Published: June 2015

Iodomethylsilyl ethers of phenols and aliphatic alkenols react to allylic silyloxycycles via Heck‐reaction.
ChemInform Abstract: Nickel‐Catalyzed Alkynylation of Anisoles via C—O Bond Cleavage.
Authors: Tobisu Mamoru , Takahira Tsuyoshi , Ohtsuki Akimichi , Chatani Naoto
Published: June 2015

This novel cross‐coupling reaction allows the alkynylation of anisole and related ethers with Grignard reagent (II).
ChemInform Abstract: Chemistry of Phosphorus Ylides. Part 37. The Reaction of Phosphonium Ylides with Indoles and Naphthofurans. Synthesis of Phosphanylidenes, Pyrans, Cyclobutenes, and Pyridazine as Antitumor Agents.
Authors: Maigali Soher S. , El‐Hussieny Marwa , Soliman Fouad M.
Published: June 2015

An interesting approach to the synthesis of a variety of new cyclic and heterocyclic phosphorus compounds via direct reaction of readily available indolinones (III) or related naphthofuranone derivatives (IX) with phosphacumulenes (IV) or phosphallene ylide (VI) is given.
ChemInform Abstract: Synthesis of Annelated Phospholes Through Intramolecular C—H Activation by Monovalent Phosphorus.
Authors: Wei Xinda , Lu Zongming , Zhao Xu , Duan Zheng , Mathey Francois
Published: June 2015

A variety of phosphole W(CO)5‐complexes is synthesized by thermolysis of the corresponding 7‐phosphanorbornadiene complexes.
ChemInform Abstract: Copper Nanoparticles Catalyzed Se(Te)—Se(Te) Bond Activation: A Straightforward Route Towards Unsymmetrical Organochalcogenides from Boronic Acids.
Authors: Mohan Balaji , Yoon Chohye , Jang Seongwan , Park Kang Hyun
Published: June 2015

Copper nanoparticles immobilized on activated charcoal are prepared and successfully employed as catalyst for the cross‐coupling of diselenides or ditellurides with boronic acids (II) and esters (IV).
ChemInform Abstract: Abietane Diterpenoids from Perovskia atriplicifolia and Their anti‐HBV Activities.
Authors: Jiang Zhi‐Yong , Li Zhong‐Qiu , Huang Chao‐Guan , Zhou Jun , Hu Qiu‐Fen , Liu Wen‐Xing , Huang Xiang‐Zhong , Wang Wei , Zhang Li‐Zhu , Xia Fu‐Ting
Published: June 2015

Three new compounds, atriplicone A (I), B (II), and C (III) are isolated together with five known compounds.
ChemInform Abstract: Palladium‐Catalyzed Stereoselective C‐Glycosylation of Glycals with Sodium Arylsulfinates.
Authors: Ma Jimei , Xiang Shaohua , Jiang Hong , Liu Xue‐Wei
Published: June 2015

C‐aryl glycosides are formed by palladium‐catalyzed carbon‐Ferrier‐type coupling with high regio‐ and stereoselectivity.
ChemInform Abstract: The Heat‐Up Synthesis of Colloidal Nanocrystals
Authors: van Embden Joel , Chesman Anthony S. R. , Jasieniak Jacek J.
Published: June 2015

Review: 426 refs.
ChemInform Abstract: Inorganic Nano‐Adsorbents for the Removal of Heavy Metals and Arsenic: A Review
Authors: Ray Phoebe Zito , Shipley Heather J.
Published: June 2015

Review: 154 refs.
ChemInform Abstract: Expanded Porphyrins: More Confusion All the Time
Authors: D'Souza Francis
Published: June 2015

Review: synthesis and characteristics of expanded prophyrins; 10 refs.
ChemInform Abstract: Applications of Sharpless Asymmetric Epoxidation in Total Synthesis
Authors: Heravi Majid M. , Lashaki Tahmineh Baie , Poorahmad Nasim
Published: June 2015

Review: [449 refs.
ChemInform Abstract: Bidentate, Monoanionic Auxiliary‐Directed Functionalization of Carbon‐Hydrogen Bonds
Authors: Daugulis Olafs , Roane James , Tran Ly Dieu
Published: June 2015

Review: 75 refs.
ChemInform Abstract: Transition Metals for the Synthesis of Glycopolymers and Glycopolypeptides
Authors: Islam Maidul , Shaikh Ashif Y. , Hotha Srinivas
Published: June 2015

Review: 72 refs.
ChemInform Abstract: Chemical Glycosylation by Single Electron Transfer
Authors: Nokami Toshiki , Itoh Toshiyuki , Mong Kwok‐Kong Tony
Published: June 2015

Review: 68 refs.
ChemInform Abstract: Chemistry of Pent‐4‐yne‐1,3‐diones (Acetylenic β‐Diketones) as Precursors for Heterocyclic Compounds
Authors: Atta Kamal F. M. , Farahat Omaima O. M. , Al‐Shargabi Tareq Q. , Marei Mohamed G. , El Ashry El Sayed H.
Published: June 2015

Review: 76 refs.
ChemInform Abstract: Bischler‐Napieralski Reaction in the Synthesis of Isoquinolines
Authors: Heravi Majid M. , Khaghaninejad Soheila , Nazari Niousha
Published: June 2015

Review: 188 refs.
ChemInform Abstract: Novel Strategies for Catalytic Asymmetric Synthesis of C1‐Chiral 1,2,3,4‐Tetrahydroisoquinolines and 3,4‐Dihydroisoquinolines
Authors: Liu Wangsheng , Liu Shasha , Jin Ruiwen , Guo Hao , Zhao Jinbo
Published: June 2015

Review: 75 refs.
ChemInform Abstract: Progress in Thermoregulated Liquid/Liquid Biphasic Catalysis
Authors: Liu Chun , Li Xinmin , Jin Zilin
Published: June 2015

Review: 63 refs.
ChemInform Abstract: Synthesis and Reactions of Five‐Membered Heterocycles Using Phase Transfer Catalyst (PTC) Techniques
Authors: El‐Sayed Ahmed M. , Abd Allah Omyma A. , El‐Saghier Ahmed M. M. , Mohamed Shaaban K.
Published: June 2015

Review: 113 refs.
ChemInform Abstract: 1,4‐Dinitro‐1H‐imidazoles
Authors: Suwinski Jerzy W.
Published: June 2015

Review: synthesis, properties, and reactions; 82 refs.
ChemInform Abstract: Multi Component Reactions and Non‐steroidal Antiinflammatory Drugs
Authors: Shaikh Sanakausar R. , Nazeruddin G. M.
Published: June 2015

Review: 69 refs.
ChemInform Abstract: Pyrazole: Synthesis, Reaction and Biological Activity
Authors: Rajput Shankarsing Sardarsing , Patel Sureshbhai Narasaibhai , Chaudhari Sandip Balu
Published: June 2015

Review: 43 refs.
ChemInform Abstract: Chemoselectivity in 1,3‐Dipolar Cycloaddition Reactions of Nitrilimines with Multifunctionalized Dipolarophiles
Authors: Shawali Ahmad S.
Published: June 2015

Review: literature from 1970 to mid 2013; 107 refs.
ChemInform Abstract: Supramolecular Chirality: Solvent Chirality Transfer in Molecular Chemistry and Polymer Chemistry
Authors: Fujiki Michiya
Published: June 2015

Review: 156 refs.
ChemInform Abstract: Pd Nanoparticles in C‐C Coupling Reactions
Authors: Pacardo Dennis B. , Knecht Marc R.
Published: June 2015

Review: 194 refs.
ChemInform Abstract: Stereochemical Studies on Pheromonal Communications
Authors: Mori Kenji
Published: June 2015

Review: 83 refs.
ChemInform Abstract: Oxidation and Reduction by Solid Oxidants and Reducing Agents Using Ball‐Milling
Authors: Cravotto Giancarlo , Gaudino Emanuela Calcio
Published: June 2015

Review: 32 refs.
ChemInform Abstract: Carbon‐Carbon Bond Forming by Ball Milling
Authors: Jacob Katharina , Schmidt Robert , Stolle Achim
Published: June 2015

Review: 61 refs.
ChemInform Abstract: Carbon‐Heteroatom Bond Forming Reactions and Heterocycle Synthesis under Ball Milling
Authors: Ranu Brindaban C. , Chatterjee Tanmay , Mukherjee Nirmalya
Published: June 2015

Review: 66 refs.
ChemInform Abstract: Alumina Sulfuric Acid (ASA), Tungstate Sulfuric Acid (TSA), Molybdate Sulfuric Acid (MSA) and Xanthan Sulfuric Acid (XSA) as Solid and Heterogeneous Catalysts in Green Organic Synthesis: A Review
Authors: Vekariya Rajesh H. , Patel Hitesh D.
Published: June 2015

Review: 63 refs.
ChemInform Abstract: Magnetoelectrics for Magnetic Sensor Applications: Status, Challenges and Perspectives
Authors: Wang Yaojin , Li Jiefang , Viehland D.
Published: June 2015

Review: 92 refs.
ChemInform Abstract: Sulfonyl Fluorides as Privileged Warheads in Chemical Biology
Authors: Narayanan Arjun , Jones Lyn H.
Published: June 2015

Review: 97 refs.
ChemInform Abstract: Combination of Ru(II) Complexes and Light: New Frontiers in Cancer Therapy
Authors: Mari Cristina , Pierroz Vanessa , Ferrari Stefano , Gasser Gilles
Published: June 2015

Review: 116 refs.
ChemInform Abstract: Emerging Energy and Environmental Applications of Vertically‐Oriented Graphenes
Authors: Bo Zheng , Mao Shun , Jun Han Zhao , Cen Kefa , Chen Junhong , Ostrikov Kostya (Ken)
Published: June 2015

Review: tutorial review on plasma synthesis of vertically‐oriented graphenes, growth mechanism, and properties for energy and environmental applications; 50 refs.
ChemInform Abstract: Recent Advancements in Pt and Pt‐Free Catalysts for Oxygen Reduction Reaction
Authors: Nie Yao , Li Li , Wei Zidong
Published: June 2015

Review: 451 refs.
ChemInform Abstract: Biomedical Applications of Cationic Clay Minerals
Authors: Ghadiri M. , Chrzanowski W. , Rohanizadeh R.
Published: June 2015

Review: 172 refs.
Second‐line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine‐platinum combination: A large multicenter study by the Association des Gastro‐Entérologues Oncologues
Authors: Brieau Bertrand , Dahan Laetitia , De Rycke Yann , Boussaha Tarek , Vasseur Philippe , Tougeron David , Lecomte Thierry , Coriat Romain , Bachet Jean‐Baptiste , Claudez Pierre , Zaanan Aziz , Soibinet Pauline , Desrame Jérome , Thirot‐Bidault Anne , Trouilloud Isabelle , Mary Florence , Marthey Lysiane , Taieb Julien , Cacheux Wulfran , Lièvre Astrid
Published: June 2015

BACKGROUND

Few data are available on second‐line chemotherapy (CT2) for advanced biliary tract cancer (ABTC). The aim of this multicenter study was to describe the CT2 regimens used, the response rates, and the outcomes of patients treated with various CT2 regimens.

METHODS

Patients who received CT2 for ABTC at 17 French institutions after the failure of the gemcitabine‐platinum combination were retrospectively studied. Progression‐free survival (PFS) and overall survival (OS) were estimated with the Kaplan‐Meier method. Cox models were used for multivariate analyses.

RESULTS

Among 603 patients who received first‐line chemotherapy (CT1) for ABTC, 196 received CT2: 5‐fluorouracil (5‐FU) and irinotecan (n = 64), 5‐FU and oxaliplatin (n = 21), 5‐FU and cisplatin (n = 38), 5‐FU or capecitabine (n = 40), sunitinib (n = 10), or other various regimens (n = 23). Among the 186 assessable patients, there were 22 partial responses and 70 stabilizations. After a median follow‐up of 26.4 months, the median PFS and OS were 3.2 and 6.7 months, respectively. There was no significant difference in PFS or OS between CT2 regimens. Fluoropyrimidine‐based doublet chemotherapy was not superior to fluoropyrimidine alone in terms of OS and PFS. In a multivariate analysis, a performance status of 0 to 1, disease control with CT1, and a carbohydrate antigen 19‐9 (CA 19‐9) level ≤ 400 IU/mL were significantly associated with longer PFS and OS. Grade 3 to 4 toxicity occurred in 32% of the patients.

CONCLUSIONS

CT2 might provide disease control for selected patients with ABTC after the failure of gemcitabine‐platinum, but the prognosis remains poor. No particular regimen seems superior to others, and this calls for new treatments. A good performance status, disease control with CT1, and a low level of CA 19‐9 were associated with longer survival. Cancer 2015;121:3290–3297. © 2015 American Cancer Society.
Effects of synthesis conditions on the yields and properties of HZSM‐5
Authors: Wang Yuan , Fan Subing , Zhang Jianli , Zhao Tian‐Sheng
Published: June 2015

In the SiO2‐Al2O3‐TPAOH‐NH4OH system through a two‐step procedure, the effects of synthesis parameters on the yields and properties of HZSM‐5 were studied. As the feeding n(SiO2)/n(Al2O3) ratio increased, the yields of synthesized samples were between 11% and 14% while the crystallinity tended to decrease at the ratio > 300. At the ratio of 150, the yield was 13.7% and the ratio of actual yield to theoretical yield was 93%. The sample shaped ellipse‐like particles of 3 × 10−6 m. At the n(NH3)/n(SiO2) ratio of 1.5, the yield was 13.1% and the sample showed regular ellipse‐like particles of 2 × 10−6 m. Too high dosage of NH4OH lowered the yield and the crystallinity. The addition of seed crystal favored the HZSM‐5 synthesis in high crystallinity. At the addition amount of 4%, the yield reached 13.9% and the sample shaped in spherical particles of 0.5 × 10−6 m. Synthesized HZSM‐5 with a surface area of 455 m2·g−1 and intrinsic acidity showed highly catalytic activity toward the methanol conversion to olefins reaction.
Channel‐aware repetitive data collection in wireless sensor networks
Authors: Kim Ryangsoo , Choi Jinho , Lim Hyuk
Published: June 2015

Wireless sensor networking technology has been applied in practice to a variety of information‐gathering infrastructures, where sensing data are repetitively delivered to a data collector within a session period. For efficient energy conservation, each sensor node can wait for a higher channel gain before it begins the transmission of sensing data and transmits them with a power that is inversely proportional to the channel gain. However, if the node waits for higher channel gain, switching to the sleeping mode takes a longer time. We formulate this channel‐aware data transmission problem using an optimization problem with linear constraints. The numerical simulations indicate that the proposed method significantly reduces the energy consumption compared with other heuristic methods. Copyright © 2015 John Wiley & Sons, Ltd.
The evolution of obligate sex: the roles of sexual selection and recombination
Authors: Kleiman Maya , Hadany Lilach
Published: June 2015

The evolution of sex is one of the greatest mysteries in evolutionary biology. An even greater mystery is the evolution of obligate sex, particularly when competing with facultative sex and not with complete asexuality. Here, we develop a stochastic simulation of an obligate allele invading a facultative population, where males are subject to sexual selection. We identify a range of parameters where sexual selection can contribute to the evolution of obligate sex: Especially when the cost of sex is low, mutation rate is high, and the facultative individuals do not reproduce sexually very often. The advantage of obligate sex becomes larger in the absence of recombination. Surprisingly, obligate sex can take over even when the population has a lower mean fitness as a result. We show that this is due to the high success of obligate males that can compensate the cost of sex.