bluuebunny/crossref_metadata_2025 huggingface dataset:
ICJ Advisory Opinion on Legal Consequences of the Separation of the Chagos Archipelago From Mauritius in 1965 (Chagos Advisory Opinion): A Critical Analysis
Authors: Mamun Md Jahid Al , Asrafuzzaman A B M
Published: November 2023

The Chagos AO is a milestone in the history of decolonization which certainly added some narratives to the jurisprudence of the right to selfdetermination, rules of identification of customary international law, and the practice of the ICJ in relation to its jurisdiction on an advisory opinion. Similarly, ICJ had missed dealing with the human rights of the inhabitants of Chagos Archipelago which was the subject matter of the opinion, whether the right to self-determination qualifies as peremptory norms or not, etc. This paper critically discusses the approach taken by the World Court in this case in five sections, e.g., the judicial propriety in the AO, the territorial aspect of the right to selfdetermination, the right to self-determination and customary international law, the right to self-determination and jus cogens, and human rights of the Chagossians.
Dhaka University Law Journal, Vol. 33(1), 2023 P.95-110
The Link between Major Depressive Disorder & Chronic Coronary Syndrome - A Literature Review
Authors: Anwar AFM Azim , Rahaman Sheikh Nashfiqur , Mumu Sanjida Anjum , Khaled Md Fakhrul Islam , Ahmed Khurshed , Hoque Md Harisul
Published: November 2023

Depression is prevalent among patients with coronary artery disease and has significant consequences. Occurrence of depression after a new diagnosis of stable angina is common and affects nearly 1 in 5 individuals. There have been several biological mechanisms by which depression may be related to coronary artery disease. As compared with nondepressed patients, those with depression have increased catecholamine levels,elevated resting heart rate, and decreased heart rate variability. . Behavioral characteristics of patients with depression include poor medication adherence, lower exercise tolerance,physical inactivity, poor dietary habits,and tobacco use. Although depression and its impact have been well documented in post-MI patients, much less is known about its significance in patients with chronic coronary syndrome(CCS).Despite the fact that CCS is the most common manifestation of coronary artery disease,sothere is a huge gap in the field of knowledge correlating CCS and depression.
University Heart Journal 2023; 19(1): 26-30
A Case of Infective Endocarditis Caused by Rapidly Growing Non-tuberculous Mycobacterium after Cardiac Catheterization
Authors: Huda SM Nurul , Kabir Mohammad Faisal Ibn , Khaled Md Fakhrul Islam , Anwar AFM Azim , Amin Md Rasul
Published: November 2023

Endocarditis caused by non-tuberculous mycobacterium is rare and often missed without appropriate blood cultures. It does not respond to standard antitubercular treatment and is also resistant to many other antibiotics. The course of the disease may be indolent and often results in a fatal outcome. Here we report a case of Nontuberculous mycobacterial endocarditis of the native aortic valve in an immunocompetent patient following coronary angiography. The case highlights an unfortunate intervention – related nosocomial infection and the difficulties in chemotherapeutic options for this organism, particularly in the presence of marrow suppression and acute interstitial nephritis.
University Heart Journal 2023; 19(1): 31-34
Yaşam Kalitesinin Yordayıcıları Olarak Psikolojik İyi Oluş ve Yaşam Doyumu
Authors: Demir Ramazan , Tanhan Ahmet , Çiçek İlhan , Yerlikaya İbrahim , Çırak Kurt Sevilay , Ünverdi Büşra
Published: November 2023

Bu araştırmada yaşam kalitesinin yordayıcıları olarak psikolojik iyi oluş ve yaşam doyumu ele alınmıştır. Bununla birlikte, yaşam kalitesi, psikolojik iyi oluş ve yaşam doyumunun demografik değişkenlere göre de incelenmiştir. Analiz sonuçlarına göre, yaşam kalitesi, yaşam doyumu ve psikolojik iyi oluş bölüm memnuniyetine göre anlamlı farklılık göstermiştir. Yaşam kalitesi, yaşam doyumu ve psikolojik iyi oluş topluluk üyeliğine, barınma şekline, teknoloji kullanım sıklığına ve arkadaş sayısına göre anlamlı farklılık göstermemiştir. Yaşam kalitesi ve yaşam doyumu düzeylerinin uykuda geçirilen süreye göre anlamlı derecede farklılaşmadığı görülmüş, psikolojik iyi oluş düzeylerinin anlamlı derecede farklılaştığı görülmüştür. Yaşam kalitesi ile yaşam doyumu arasında pozitif ve orta düzeyde, yaşam kalitesi ile psikolojik iyi oluş arasında pozitif ve orta düzeyde, yaşam doyumu ile psikolojik iyi oluş arasında pozitif ve orta düzeyde ilişki tespit edilmiştir. Yaşam doyumu ve psikolojik iyi oluş değişkenleri, yaşam kalitesi ile anlamlı bir ilişki sergilemiştir. Söz konusu iki değişken yaşam kalitesi puanlarındaki değişimin %41’ini açıklamıştır.
PENERAPAN TEKNOLOGI WEB SCRAPING SEBAGAI PENGUMPULAN DATA COVID-19 DI PROVINSI LAMPUNG
Authors: Fadhlullah Nurman , Setiawansyah Setiawansyah , Surahman Ade
Published: November 2023

Pada 30 Januari 2020, Organisasi Kesehatan Dunia menyatakan wabah virus corona baru (COVID-19)sebagai daruratÂ  kesehatanÂ  masyarakatÂ  dunia.Â  Covid-19Â  sendiri merupakanÂ  kelompokÂ  virusÂ  yang terdapat pada hewan dan manusia. Untuk merespon COVID-19 diperlukan persiapan dan respon kritis, seperti membekali petugas kesehatan dengan peralatan yang lengkap dan mengelola fasilitas kesehatan untuk memberikan informasi, prosedur yang aman dan efektif. Banyaknya data yang ditampilkan dari masing-masing website membuat pencari data bingung website mana yang harusnya dia pilih untuk mencari data yang dia inginkan. Dari permasalah tersebut, maka penulis menggunakan metode web scraping sebagai upaya mencari data covid-19 dan membandingkan website mana yang paling aktif dalam membuat berita tentang covid-19 di provinsi lampung. Data akan diambil dari 3 (tiga) website berita yang ada di provinsi lampung yaitu lampung post, radar lampung, dan tribun lampung. Data yang akan diambil dari tiga website tersebut yaitu berupa judul dan link. Web scraping akan sangat tepat dalam penelitian ini, karena pengambilan data yang terstruktur dari teknik tersebut. Dalam penelitian ini digunakan library python untuk memudahkan dalam penerapan web scraping. Hasil penelitian ini, teknik web scraping yang penulis terapkan dapat mengambil data dari tiga website, sehingga data tersebut dapat ditampilkan sebagai upaya membandingkan website mana yang lebih aktif memuat berita covid-19 di provinsi lampung.
PENERAPAN AUGMENTED REALITY (TANAMAN OBAT KELUARGA) TOGA SEBAGAI MEDIA PEMBELAJARAN BERBASIS ANDROID DENGAN METODE MARKER
Authors: Alfian Muhammad
Published: November 2023

PKK (pemberdayaan kesejahteraan keluarga) adalah organisai yang memungkinkan perempuan secara efektif memberdayakan dan berpatisipasi dalam pembangunan atas dasar kesetaraan. PKK (pemberdayaan kesejahteraan keluarga) merupakan gerakan masyarakat yang bertujuan memberdayakan keluarga untuk meningkatkan kesejahteraan. pkk memiliki 10 program kerja yang salah salah satunya membahat tentang konsultasi sosialisasi tanaman obat indonesia, khususnya dibidang pangan dan kesehatan. Ibu rumah tangga di Kecamatan Bakung aktif mengikuti kegiatan bulanan PKK (Pemberdayaan Kesejahteraan Keluarga) yang dibina desa. Kegiatan PKK (Peningkatan Kesejahteraan Keluarga) biasanya lebih banyak mendapat materi konsultasi dari semua pihak. kegiatan PKK (Pemberdayaan Kesejahteraan Keluarga) tidak pernah mendapatkan konsultasi dan pelatihan tentang pengolahan atau pengenalan TOGA (Tanaman Obat keluarga). Oleh karena itu, penelitian ini bertujuan untuk menghasilkan aplikasi media pembelajaran berbasis mobile dengan menerapkan Augmented Reality yang berfokus pada Tanaman Obat Keluarga dengan memanfaatkan Smartphone, dengan materi yang bersumber dari seseorang yang mengetahui Tanaman Obat Keluarga.Pembangunan aplikasi media pembelajaran ini menggunakan software Blender untuk mengembangkan model 3D, software Unity untuk menyatukan komponen-komponen yang dibutuhkan dalam pengembangan aplikasi sehingga menciptakan suatu hasil akhir aplikasi mobile android. aplikasi Augmented Reality Tanaman Obat Keluarga.
PERBANDINGAN ARSITEKTUR VGG16 DAN RESNET50 UNTUK REKOGNISI TULISAN TANGAN AKSARA LAMPUNG
Authors: Rikendry Rikendry , Maharil Azzin
Published: November 2023

Pengenalan tulisan tangan atau biasa disebut Hand Writing Recognition (HWR)adalahsebuah sistem komputer yang dapat digunakan untuk mengenali huruf yangberasal dari tulisanÂ tangan. HWR sendiri merupakan sistem yang dikembangkandari Optical Character RecognitionÂ (OCR), dengan adanya sistem HWR inidiharapkan komputer dapat membaca dan mengenaliÂ huruf-huruf ataupun karakteryang dimasukkan oleh user dalam bentuk tulisan tangan. Data yangÂ digunakan padapenelitian ini berupa data gambar tulisan tangan aksara lampung sebanyak 20Â aksara. Pada penelitian kali ini penulis akan membandingkan dua model deeplearning yaituÂ VGG16 dan ResNet50. Hasil dari penelitian ini menunjukan bahwamodel arsitektur VGG16Â memberikan hasil akurasi 91% serta waktu training yanglebih baik, sedangkan untuk ResNet50Â memberikan hasil akurasi sebesar 65% danmemerlukan waktu komputasi yang lebih lama danÂ hasil akurasi yang kecil
RANCANGAN UI/UX PADA GAME BELAJAR AKSARA LAMPUNG BERSAMA MULI (STUDI KASUS : SEKOLAH DASAR SWADHIPA NATAR)
Authors: Kurniawan Angga Yudi
Published: November 2023

Aksara Lampung merupakan bentuk tulisan yang memiliki hubungan dengan aksara Pallawa dari India Selatan. Saat ini minat dan keinginan masyarakat terutama di kalangan anak-anak dalam mempelajari Aksara Lampung semakin menurun. Dalam perkembangan teknologi yang ada saat ini, diperlukan sebuah media pendukung pembelajaran yang interaktif dan menghibur dengan tetap mengikuti perkembangan teknologi yang ada. Seiring dengan perkembangan zaman dan teknologi, saat ini adat dan budaya tergerus dan sudah mulai daerah ditinggalkan oleh masyarakat. Masyarakat Lampung khususnya kalangan pelajar telah terpengaruh akan budaya-budaya luar yang masuk sehingga mengakibatkan kurangnya ketertarikan untuk mempelajari budaya daerah Lampung khususnya bahasa dan Aksara daerah yang seharusnya dilestarikan dan dipelihara. Penggunaan simulasi dan game digital dalam proses pembelajaran diperkirakan akan meningkat selama beberapa tahun ke depan. Banyak prediksi yang menyatakan teknologi akan membawa perubahan baik pada dunia pendidikan. Melalui sebuah game edukasi Belajar Aksara Lampung Bersama Muli para siswa dapat belajar aksara daerah lampung secara santai dan menyenangkan. Selain itu, game Belajar Aksara Lampung Bersama Muli juga dapat membantu dalam pengembangan keterampilan siswa melalui proses bermain, seperti mengenal aksara lampung, mengenal anak huruf, dan menulis anak huruf dan didalam game dipandu oleh suara seorang wanita yang bernama muli yang mendukung proses pembelajar lebih menarik dan menyenangkan. Kata Kunci: Aksara Lampung, Aksara Palawa, Belajar akasara lampung bersama muli, Game edukasi
APLIKASI EDUKASI TEKNIK SENAM YOGA BERBASIS ANDROID
Authors: Saputra Rendi
Published: November 2023

Salah satu cara untuk meningkatkan taraf kesehatan diri adalah dengan senam yoga. Senam yoga merupakan senam yang menyatukan jiwa dalam keselarasan yang alami dan menyatukan kesadaran diri terhadap Tuhan Yang Maha Kuasa.Senam yoga juga dapat menstimulasi pengeluaran hormone endorphin. Hormon endorphin merupakan neuropeptide yang dihasilkan tubuh di otak dan susunan syaraf tulang belakang pada saat kondisi seseorang sedang relaks. Selain sebagai salah satu alternatif daya tahan tubuh terdahap stress, yoga juga menjadi gaya hidup dimana saat ini sudah terdapat beberapa sanggar yoga di Lampung yang dilatih khusus oleh beberapa personal trainer. Personal trainer ini membantu para anggota untuk memahami teknik-teknik senam yoga, selain itu juga memberikan informasi mengenai asupan nutrisi yang diperlukan tubuh untuk menunjang progam.Hal ini tentunya menjadi batasan pada sanggar yoga dalam aktifitasnya karena personal trainer dapat memberikan arahan hanya pada sanggar. Dengan kemajuan teknologi saat ini terutama teknologi mobile android batasan yang dialami oleh suatu sanggar senam yoga dapat diatasi dengan sebuah aplikasi yang dapat membantu seorang pemula untuk memahami teknik-teknik senam yoga. Sehingga para pemula dapat berlatih teknik senam yoga dimanapun dan kapanpun tanpa harus ke sanggar yoga.
Aplikasi Sistem Informasi Manajemen Aset Berbasis Android pada PT Telekomunikasi Indonesia Tbk Lampung
Authors: Syidik Arief Aryudi , Sulistiani Heni
Published: November 2023

Penelitian ini bertujuan membuat aplikasi atau sistem untuk memudahkan pihak PT Telkom Indonesia Witel Lampung dalam mengelola data aset perusahaan, baik secara administrasi dan dokumentasi dengan memanfaatkan teknologi mobile Android. Dengan adanya aplikasi ini diharapkan dapat memberikan kemudahan manajemen atau pengelolaan data aset secara detail, pencarian data aset, pelaporan aset dan monitoring aset secara real-time serta keseluruhan. Sehingga dapat menjadi solusi dari permasalahan yang ada. Aplikasi mobile walaupun hanya dapat dijalankan pada perangkat mobile, namun dapat memberikan user experience yang lebih baik karena semua dapat dijalankan dalam genggaman tangan dan dapat memanfaatkan fitur-fitur native dari perangkat yang ada. Aplikasi yang dibuat memudahkan Staf Administrasi Aset dalam melakukan pengelolaan data aset dan Mitra dalam melihat informasi terkait data aset yang ada pada PT Telkom Indonesia Witel Lampung. Pengujian aplikasi menggunakan ISO 25010 dengan dua karakteristik yaitu, functional suitability (kesesuaian fungsi) dan usability (kemudahan pengguna). Berdasarkan data dari total perhitungan uji functionality suitability dan usability diperoleh skor sebesar 100% pada masing-masing pengujian, sehingga dapat disimpulkan bahwa responden Sangat Setuju terhadap aplikasi yang telah dibuat dan aplikasi yang dibuat telah sesuai dengan yang diharapkan pengguna.
Aplikasi Pencarian Dan Pemesanan Jasa Makeup Dan Pakaian Pengantin Berbasis Android Di Bandar Lampung
Authors: Hidayahtullah Ali , Styawati Styawati , Ardiansah Temi
Published: November 2023

Smartphone android merupakan alat yang dapat digunakan untuk mempermudah aktifitas sehari-hari, seperti memesan jasa layanan dan lain-lain. Dalam penelitian ini ditemukan beberapaÂ  permasalahan antara konsumen dengan penyedia jasa, seperti pengaturan jadwal pemesanan, dan pemilihan jasa yang tepat, sehingga adanya aplikasi ini bisa menghubungkan konsumen dan penyedia jasa makeup saling bertukar informasi.Penelitian ini menggunakan metode pengumpulan data dan wawancara, observasi dan studi literatur. Metode perancangan yang digunakan adalah prototype dan teknik pengujian yang digunakan adalah iso/tec 25010.Dari penelitian ini menghasilkan aplikasi pemesanan jasa makeup dan pakaian pengantin, serta dapat menampilkan daftar profil penyedia jasa, harga yang ditawarkan serta nama dan jenis makeup, aplikasi ini berbasis android yang dapat diakses menggunakan smartphone. Selain itu sistem ini juga telah diuji dengan pengujian Iso 25010, dan berdasarkan pengujian yang dilakukan dapat dikatakan berhasil, karena sudah melampaui batas yaitu 80% sehingga sistem dinyatakan layak untuk digunakan.Berdasarkan kesimpulan hasil pengujian dengan pengujian Iso 25010 menunjukkan bahwa aplikasi ini mudah digunakan dan pengujian yang dilakukan dapat dikatakan berhasil, karena sudah melampaui batas yaitu 80% sehingga sistem dinyatakan layak untuk digunakan oleh konsumen.
Sistem Informasi Geografis Untuk Pemetaan Jalur Evakuasi Bencana Tsunami Di Desa Way Muli Kabupaten Lampung Selatan
Authors: Putra Indra Pratama , Neneng Neneng , Megawaty Dyah Ayu
Published: November 2023

Sistem Informasi Geografis (SIG) adalah sistem komputer yang digunakan untuk mengumpulkan, memeriksa, mengintegrasikan, dan menganalisa informasi-informasi yang berhubungan dengan permukaan bumi. Dengan adanya SIG diharapkan memberikan informasi mitigasi bencana, mengidentifikasi pemetaan jalur utama evakuasi dan menentukan zona aman untuk pengungsi di Desa Way Muli. Pembuatan Sistem Informasi Geografis ini berdasarkan tahapan yaitu mendifinisikan masalah, pengumpulan data, isi, menguji aplikasi. Dalam menyelesaikan sistem ini menggunakan metode pengembangan Extreme Programming, dengan metode pengembangan ini teknnik pengumpulan data yang digunakan yaitu studi pustaka dan studi lapangan. Sistem Informasi Geografis ini merupakan aplikasi yang akan memberikan informasi mitigasi bencana untuk masyarakat, menentukan zona aman untuk tempat pengungsian dan sistem ini diharapkan sebagai rujukan untuk simulasi evakuasi bencana Tsunami. Hasil dari penelitian membangun sebuah sistem informasi pemetaan jalur evakuasi di wilayah Kabupaten Lampung Selatan Desa Way Muli berbasis web dapat menggunakan layanan Open Layer yaitu suatu layanan yang telah disediakan oleh Google untuk menampilkan maps pada aplikasi yang akan dibuat dan Informasi yang dihasilkan dari pembuatan aplikasi dalam penelitian ini yaitu menyajikan peta jalur evakuasi dengan memilih rute yang dituju hingga sampai ke titik posko.
Implementasi Metode Certainty Factor untuk Deteksi Kerusakan Mesin CNC Plasma Cutting Hypertherm
Authors: Setyarto Bambang Dwi , Sulistiani Heni , Darwis Dedi , Dellia Prita
Published: November 2023

Salah satu contoh contoh penggunaan teknologi dalam industri manufaktur adalah Computer Numerical Controlled (CNC). Kelebihan pada mesin CNC adalah ketelitian dan kepresisian yang tinggi ini dapat disuguhkan oleh workshop di industri manufaktur yang telah memiliki mesin-mesin yang handal dan bekerja secara otomatis seperti mesin komputer. Computer Numerical Control (CNC) merupakan salah satu komponen inti dalam suatu proses manufaktur presisi yang harus dikuasai oleh mahasiswa terutama mahasiswa teknik mekatronika. Mesin CNC Plasma Cuting yang digunakan oleh PT. Lampung Andalas Shipbuilding dan Engineering adalah mesin CNC Plasma Cutting merek hyperterm, Teknisi yang bertugas mengoperasikan mesin tersebut akan mendapat pelatihan dari pihak produsen tentang bagaimana mengoperasikannya. Saat ini diagnosa masalah pada mesin CNC Plasma Cutting masih dilakukan secara manual berdasarkan buku panduang yang diberikan oleh vendor. Buku panduan tersebut hanya diajarkan kepada kepala teknisi pada PT. Lampung Andalas. Namun, jika kepala teknisi sedang tidak bekerja operator sering mengalami kendala ketika terjadi masalah pada mesin CNC Plasma Cutting. Maka dari itu perlu dibangun sebuah sistem pakar menggunakan Certanty Factor (CF) untuk membantu diagnose kerusakan pada mesin CNC Plasma Cutting terutama pada masalah-masalah yang paling sering dialami oleh mesin CNC Plasma Cutting.
Implementasi Metode Simple Additive Weighting pada Sistem Pendukung Keputusan Penentuan Biji Kopi Berkualitas
Authors: Bagaskara Muhammad Rahadiyan , Priandika Adhie Thyo , Sintaro Sanriomi , Setiawansyah Setiawansyah
Published: November 2023

Perkembangan tren kedai kopi yang pesat terjadi di Kota Bandar Lampung, salah satunya adalah Sakara Coffee. Dalam menentukan green bean yang akan diolah menjadi minuman, Sakara Coffee masih menggunakan cara manual. Selebihnya, penentuan green bean hanya terbatas pada informasi dari para petani. Sistem yang tepat sesuai dengan permasalahan tersebut adalah Sistem Pendukung Keputusan (SPK). Penelitian ini bertujuan untuk menerapkan metode Simple Additive Weighting (SAW) dalam pengembangan sistem pendukung keputusan penentuan biji kopi berkualitas berbasis website. Penelitian ini mengunakan metode pengembangan Extreme Programming (XP) dan pengujian sistem menggunakan ISO/IEC 25010 dan perbandingan hasil perhitungan dari Microsoft Excel dan website. Pengembangan SPK diawali dengan menentukan kriteria dan alternatif. Green bean robusta yang digunakan berasal dari Kabupaten Lampung Barat, Kabupaten Tanggamus, dan Kabupaten Pesawaran dengan kriteria kadar air, aroma, ukuran, dan nilai cacat. Sistem memberikan fungsi untuk membuat (create), memperbarui data (update), menghapus data (delete), dan mencari data (search). Hasil akhir dari SPK ini adalah perankingan nilai biji kopi berkualitas berdasarkan hasil perhitungan. Hasil pengujian usability adalah sebesar 97,8%, pengujian functional suitability juga menunjukkan hasil yang sempurna yaitu sebesar 100%, dan hasil pengujian performance efficiency adalah sebesar 95%. Selain itu, hasil perhitungan yang diperoleh dari Microsoft Excel sama dengan hasil perhitungan dari website, maka dapat dikatakan bahwa sistem yang dikembangkan telah berhasil.
Penerapan Framework Laravel Pada Sistem Informasi Posyandu Berbasis Website
Authors: Saefudin Muhammad , Megawaty Dyah Ayu , Alita Debby , Arundaa Rillya , Tenda Edwin
Published: November 2023

Majunya perkembangan teknologi informasi sudah menjamah seluruh lapisan masyarakat, sehingga mendorong semua lapisan masyarakat untuk maju dan dapat menggunakannya. Teknologi informasi dibutuhkan untuk membantu meningkatkan kinerja organisasi. Ketika penataan informasi yang dilakukan secara teratur, tepat, jelas, cepat dan dapat disajikan dengan sebuah laporan, tentunya mendukung kelancaran operasional organisasi dan mempercepat pengambilan keputusan yang tepat. Informasi yang tepat, akurat dan terkini juga sangat dibutuhkan dalam berbagai bidang salah satunya yaitu di bidang Kesehatan. Berdasarkan permasalahan di atas, peneliti bertujuan untuk membuat suatu sistem posyandu berbasis website sebagai sarana untuk mempermudah kader maupunÂ  masyarakat dalam kegiatan posyandu. Adapun fitur yang disediakan dalam sistem ini yaitu fitur data anak, data imunisasi, data ibu hamil dan data peserta KB. Hasil daripada penelitian ini adalah Sistem yang dibuat dengan menerapkan framework Laravel ini sangat memudahkan bagi admin ataupun kader posyandu yang bertugas dalam mengelola data, sehingga dalam hal pengelompokan ataupun pencarian data menjadi lebih efisien.
Pengembangan Dan Penerapan Sistem Computer Assisted Test (CAT) Untuk Mengelola Ujian Berbasis Website
Authors: Astino Yohanes Rozi , Sabandar Vederico Pitsalitz
Published: November 2023

SMA Fransiskus Bandar lampung proses ujian dari penyajian, pendistribusian soal masih dilakukan manual. pembuatan hasil ujian pada saat pelaksanaan ujian masih dilakukan secara kovensional, proses seperti ini, memerlukan waktu dan biaya yang lebih dalam pelaksanaan ujian. Solusi dari permasalahan tersebut adalah dengan membangun sistem ujian online. Sistem ujian online dikembangkan dengan menggunakan metode prototype serta dibuat dengan menggunakan bahasa Pemrograman PHP dan MySQL untuk pembuatan database-nya serta Unified Modelling language (UML) untuk pembuatan perancangannya Sistem ujian online yang telah dikembangkan dapat membantu mempermudah guru untuk membuat dan menyajikan soal ke siswa dibandingkan dengan sistem yang lama karena masih dilaksanakan secara konvensional, dapat mempermudah siswa dan guru dalam pelaksanaan ujian serta menghasikan hasil ujian secara cepat atau real time dan akurat, meminimalisir biaya dalam pembuatan soal dikarenakan sistem lama memerlukan banyak kertas, sedangkan sistem baru menyajikan soal dalam bentuk digital yang dapat dilihat dan digunakan untuk ujian didalam sistem. Hasil pengujian untuk kelayakan sistem ujian online, menghasilkan berdasarkan pengukuran skala likert mendapatkan kategori sangat baik, sehingga dapat disimpulkan sistem yang telah dikembangkan layak diterapkan dan digunakan pada SMA Fransiskus Bandar Lampung sebagai sistem ujian online berbasis CAT.
Pengembangan Aplikasi Pengaduan Nasabah Berbasis Website Menggunakan Framework Laravel (Studi Kasus : PT BPR UTOMO MSL)
Authors: Andriano Edwin Dwi , Ahmad Imam , Gunawan Rakhmat Dedi
Published: November 2023

Pengembangan sistem pengaduan nasabah ini bertujuan untuk mengoptimalkan proses pencatatan transaksi yang berhubungan dengan pengaduan nasabah serta dapat membantu dalam proses pelaporan ke pada pihak ke tiga yaitu OJK (Otoritas Jasa Keuangan) dan dapat meningkatkan efisiensi tenaga dan waktu. Metode penelitian yang digunakan yaitu metode analisis dan perancangan. Metode analisis dilakukan dengan cara melakukan wawancara kebutuhan sistem yang di perlukan dalam pencatatan pengaduan nasabah yang selama ini masih dilakukan secara manual. Metode perancangan yaitu merancang sistem yang baru dengan cara pendekatan berorientasi objek dengan pemodelan visual UML. Pengembangan aplikasi berbasis web yang dibuat dengan bahasa pemrograman PHP dengan menggunakan framework laravel dan database MySQL. Pengujian dalam penelitian pengembangan aplikasi ini dilakukan dengan pengujian hasil laporan yang akan di hasilkan apakah sesuai dengan yang di butuhkan PT BPR Utomo Manunggal Sejahtera Lampung. Pengujian sistem dalam penelitian ini menggunakan pengujia blackbock, Pengujian blackbock dilakukan sebagai proses pengujian kinerja atau tingkat keberhasilan suatu sistem. Pengujian ini dilakukan untuk memastikan sejauh mana sistem memiliki tingkat keberhasilan pada pengujian blackbock. Pengujian hasil laporan dan pengujian blackbock dilakukan pengujian dari pihak PT BPR Utomo Manunggal Sejahtera Lampung. Dan memiliki hasil uji yang baik dan dapat membantu dalam proses pencatatan dan pelaporan pengaduan nasabah.
A study of developing a scale of problem-solving self-efficacy
Authors: KIRAL-DEMİR Büşra , KATRANCI Yasemin
Published: November 2023

The primary goal of education is to help people become better problem solvers by utilizing their thinking and mental abilities. As a result, affective factors should be considered in addition to cognitive factors. Self-efficacy is one of these affective factors. Self-efficacy refers to people's beliefs about their skills to perform a task and succeed by organizing necessary activities. In this case, problem-solving self-efficacy is defined as one's belief in one's own ability to deal with problems patiently. In this study, we aimed to develop a scale to measure problem-solving self-efficacies. The study was executed according to scale development stages. Data were collected from 422 eighth-grade students in Turkey's public middle schools to develop and validate the scale. Exploratory factor analysis was used to determine the scale's factor structure and confirmatory factor analysis was performed to test the resulting structure. In addition, item analysis of the scale items was executed. As a result of the exploratory factor analysis, it was seen that the scale had two factors. However, according to the confirmatory factor analysis, it was determined that all values provided a good or perfect fit. Furthermore, Cronbach's alpha coefficient for the entire scale was 0.91; for subfactors, 0.88 and 0.87, respectively, indicating that the scale is highly reliable. A high validity and reliability scale was eventually developed to determine problem-solving self-efficacy. Studies in the literature show that students' self-efficacy is related to their problem-solving skills. Therefore, we propose additional research to investigate the developed scale's effect on students while considering demographic factors.
ChatGPT (GPT-3.5) as an assistant tool in microbial pathogenesis studies in Sweden: a cross-sectional comparative study
Authors: Hultgren Catharina , Lindkvist Annica , Özenci Volkan , Curbo Sophie
Published: November 2023

ChatGPT (GPT-3.5) has entered higher education and there is a need to determine how to use it effectively. This descriptive study compared the ability of GPT-3.5 and teachers to answer questions from dental students and construct detailed intended learning outcomes. When analyzed according to a Likert scale, we found that GPT-3.5 answered the questions from dental students in a similar or even more elaborate way compared to the answers that had previously been provided by a teacher. GPT-3.5 was also asked to construct detailed intended learning outcomes for a course in microbial pathogenesis, and when these were analyzed according to a Likert scale they were, to a large degree, found irrelevant. Since students are using GPT-3.5, it is important that instructors learn how to make the best use of it both to be able to advise students and to benefit from its potential.
Abundance and distribution of flying fishes (Exocoetidae) and flying squids (Ommastrephidae) in the Eastern Atlantic Ocean based on a large-scale visual survey
Authors: Pierucci A , Suaria G
Published: November 2023

Flying fishes (Teleostei: Exocoetidae) and flying squids (Cephalopoda: Ommastrephidae) are key components of tropical and subtropical epipelagic ecosystems, but information about their ecology, abundance and global distribution is still scant. Here we present some notes on the occurrence of flying fishes and flying squids in the Eastern Atlantic Ocean along a large-scale visual transect between 31°S and 53°N. The density of airborne specimens startled by the passage of the ship was used as a proxy of their abundance. The number of flying individuals was estimated using visual census, and individual densities were computed according to a fixed-width strip transect protocol. During the survey, 119 vessel-based transects were performed during March and April 2017, for a total surveyed length of 1540.8 km. Flying squids were observed only in a narrow latitudinal band between 17.5° and 26.1°S. Flying fish abundance, on the other hand, varied significantly along the ship’s route. Maximum densitities occurred between 3° and 15°S. Flying fish abundance markedly decreased around the equator and then increased again towards 8-10°N. No flying fishes were seen north of 19°N, with the only exception of 4 individuals sighted near the Strait of Gibraltar (35-36°N). No attempt was made to identify fishes or squids down to the genus or species level; however, the observed variations in size class distribution suggest a certain degree of habitat segregation between different species or life stages. Sea surface temperature was the best descriptive variable explaining the distribution of flying fishes in the area surveyed. Further work is needed to better understand the environmental factors governing the distribution of these important, but seldom surveyed, organisms.
Experimental Evaluation of the Pharmacological Safety of a New Propagandic Acid Derivative with a Cardiotropic Action
Authors: Ivkin D. Yu. , Karpov A. A. , Kovanskov V. E. , Titovich I. A.
Published: November 2023

We present the results of experimental studies into the pharmacological safety of a pharmaceutical substance 4-[(3-oxo-3-ethoxypropanoyl)amino]benzoic acid (Etmaben) under a single intragastric administration at various experimental doses (60–3000 mg/kg) to female laboratory outbred rats. A clinical examination of the experimental animals was carried out in order to identify signs of intoxication. To that end, the level of food and water consumption was assessed and biochemical blood tests were performed. In addition, the state of the central nervous and cardiovascular systems, physical endurance, and respiratory rate were assessed. The tested pharmaceutical substance in the studied doses after a single intragastric administration to female rats had no negative effect on the behavior, blood parameters, the state of the central nervous system and the cardiovascular system of experimental animals.
Manganese(II) ions suppress the transcription of the citrate exporter encoding gene cexA in Aspergillus niger
Authors: Reinfurt Aline , Fritsche Susanne , Bíró Vivien , Márton Alexandra , Ellena Valeria , Fekete Erzsébet , Sándor Erzsébet , Karaffa Levente , Steiger Matthias G.
Published: November 2023

Aspergillus niger is an important filamentous fungus used for the industrial production of citric acid. One of the most important factors that affect citric acid production is the concentration of manganese(II) ions present in the culture broth. Under manganese(II)-limiting conditions, the fungus develops a pellet-like morphology that is crucial for high citric acid accumulation. The impact of manganese(II) ions on the transcription of the major citrate exporter encoding gene cexA was studied under manganese(II)-deficient and -sufficient conditions. Furthermore, citric acid production was analyzed in overexpression mutant strains of cexA in the presence and absence of manganese(II) ions, and the influence of CexA on fungal morphology was investigated by microscopy. Transcriptional upregulation of cexA in the absence of manganese(II) ions was observed and, by decoupling cexA expression from the native promoter system, it was possible to secrete more citric acid even in the presence of manganese. This effect was shown for both an inducible and a constitutive overexpression of cexA. Furthermore, it was found that the presence of CexA influences fungal morphology and promotes a more branched phenotype. According to this study, manganese(II) ions suppress transcription of the citrate exporter cexA in Aspergillus niger, causing citric acid secretion to decrease.
New strategy of personalized tissue regeneration: when autologous platelet concentrates encounter biomaterials
Authors: Ren Sicong , Wang Hanchi , Ma Sijia , Zhou Jing , Zhai Jingjie , Zhu Yuemeng , Chen Sheng , Chen Siyu , Jia Kewen , Xu Wenzhou , Zhou Yanmin
Published: November 2023

Components in blood play an important role in wound healing and subsequent tissue regeneration processes. The fibrin matrix and various bioactive molecules work together to participate in this complex yet vital biological process. As a means of personalized medicine, autologous platelet concentrates have become an integral part of various tissue regeneration strategies. Here, we focus on how autologous platelet concentrates play a role in each stage of tissue healing, as well as how they work in conjunction with different types of biomaterials to participate in this process. In particular, we highlight the use of various biomaterials to protect, deliver and enhance these libraries of biomolecules, thereby overcoming the inherent disadvantages of autologous platelet concentrates and enabling them to function better in tissue regeneration.
Perceptions and preparedness of secondary teacher trainees to foster inclusive schools for all
Authors: Arias-Pastor Mercedes , Van Vaerenbergh Steven , Fernández-Solana Jessica , González-Bernal Jerónimo J.
Published: November 2023

Introduction

The advancement of inclusive education over the past few decades emphasizes the pivotal role of teachers in transforming the educational landscape. As schools transition toward a more inclusive approach, it is imperative to evaluate the efficacy of initial teacher training programs in preparing educators for this inclusive transition. This study aims to describe the preparedness and perceptions of students in the Master’s Degree in Secondary Education, Vocational Training, and Language Teaching (MDSE) regarding inclusive education, guided by the profile developed by the European Agency for the Development of Special Needs and Inclusive Education (AEDNEEI).

Methods

Furthermore, the research analyzes how external factors, such as perceived self-efficacy, influence these perceptions and readiness for inclusive teaching. A total of 218 students enrolled in the MDSE, with an average age of 31.5 years and a standard deviation of 6, were examined. Of the participants, 33% were male and 67% were female. These students came from different Spanish universities and were either in the final stages of their studies or had already completed them. Prior to participating, they had finished the generic module and completed their practice sessions in secondary education centers. The “Teacher Training in Secondary Education: Key Elements for Teaching in an Inclusive School for All” (TTSE-IN) questionnaire was employed, which includes five validated and pertinent instruments, with four of them being employed for the study’s objectives: The “Questionnaire for Future Secondary Education Teachers about Perceptions of Diversity Attention,” the “Questionnaire for the Evaluation of Teacher Training for Inclusion CEFI-R,” the “Revised Scale of Feelings, Attitudes, and Concerns about Inclusive Education” (SACIE-R), and the “Brief Scale of Teacher Self-Efficacy.”

Results and Discussion

The results show the presence of positive attitudes in future educators along with a poor overall assessment of the training received, which raises concerns about the development of teaching functions more related to daily work in the classroom and the implementation of inclusive methodologies. At the same time, both regular and close contact with people in situations of special vulnerability, experience in training in nonformal contexts, and the level of teacher self-efficacy, in its different components, are postulated as some of the facilitators of the development of the postulates and values of inclusive education and predictors of greater capacity toward attention to diversity.
Relocation of hydropower immigrants and transformation of farmers’ energy consumption structure: an empirical study from western China
Authors: Zhao Lei , Du Xingduan , Zhang Haixia
Published: November 2023

Based on the research perspective of hydropower migration, the energy consumption structure of farmers in western China was analyzed. The OLS, Probit, and propensity score matching models are used to empirically analyze the impact of the relocation of hydropower immigrants on the household energy consumption structure. The results show that: 1) Although the relocation of hydropower immigrants increases the energy consumption burden of farmers to a certain extent, it has a significant inhibitory effect on the quantity of energy consumption and can promote the improvement of the quality of energy consumption. 2) The age structure of the head of household is different in the impact of the relocation of hydropower immigrants on the energy consumption choices of the households. This difference has different effects on different groups and energy consumption structure, especially in the impact on the energy consumption quality of the households with duality. 3) For low-income households, the economic burden of improving the quality of energy consumption is still large, and income is still an important factor affecting the transformation and upgrading of the energy consumption structure of households. 4) Mechanism analysis shows that the relocation of hydropower immigrants can reduce the dependence of households on the quantity of energy consumption by affecting the increase of non-agricultural income and the decrease of agricultural income, but it cannot affect the quality of households’ energy consumption. 5) The moderating effect shows that the relocation of hydropower immigrants can enrich the information types and information elements of farmers, and coordinate the household energy consumption decisions affecting farmers from both digital information and traditional information, thus promoting the transformation and upgrading of the household energy consumption structure of farmers.
Identification of drug candidates targeting monocyte reprogramming in people living with HIV
Authors: Knoll Rainer , Bonaguro Lorenzo , dos Santos Jéssica C. , Warnat-Herresthal Stefanie , Jacobs-Cleophas Maartje C. P. , Blümel Edda , Reusch Nico , Horne Arik , Herbert Miriam , Nuesch-Germano Melanie , Otten Twan , van der Heijden Wouter A. , van de Wijer Lisa , Shalek Alex K. , Händler Kristian , Becker Matthias , Beyer Marc D. , Netea Mihai G. , Joosten Leo A. B. , van der Ven Andre J. A. M. , Schultze Joachim L. , Aschenbrenner Anna C.
Published: November 2023

Introduction

People living with HIV (PLHIV) are characterized by functional reprogramming of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess technical feasibility of omics technologies for application to larger cohorts, we compared multiple omics data layers.

Methods

Bulk and single-cell transcriptomics, flow cytometry, proteomics, chromatin landscape analysis by ATAC-seq as well as ex vivo drug stimulation were performed in a small number of blood samples derived from PLHIV and healthy controls from the 200-HIV cohort study.

Results

Single-cell RNA-seq analysis revealed that most immune cells in peripheral blood of PLHIV are altered in their transcriptomes and that a specific functional monocyte state previously described in acute HIV infection is still existing in PLHIV while other monocyte cell states are only occurring acute infection. Further, a reverse transcriptome approach on a rather small number of PLHIV was sufficient to identify drug candidates for reversing the transcriptional phenotype of monocytes in PLHIV.

Discussion

These scientific findings and technological advancements for clinical application of single-cell transcriptomics form the basis for the larger 2000-HIV multicenter cohort study on PLHIV, for which a combination of bulk and single-cell transcriptomics will be included as the leading technology to determine disease endotypes in PLHIV and to predict disease trajectories and outcomes.
Changing nutritional seascapes of kelp forests
Authors: Shalders Tanika C. , Champion Curtis , Benkendorff Kirsten , Davis Tom , Wernberg Thomas , Morris Stephen , Coleman Melinda A.
Published: November 2023

Ocean warming and short-term extreme events (e.g. marine heatwaves) are becoming more intense and frequent and have had major impacts on ecosystems. Seaweeds are foundational components of temperate reefs, providing nutrition for a diversity of species and underpinning temperate food webs. While the impacts of climate-driven environmental change on seaweed distribution, abundance and interactions are well studied, potential impacts on the provision of nutrients from seaweeds and their availability to consumers remain poorly understood. Here, we use metabolomic and lipidomic approaches to understand how the provision of nutrients from key seaweeds may be altered under climate change. We optimize a small-scale microextraction technique to test the effects of warming and marine heatwaves on the nutritional quality of two Australian habitat-forming seaweeds; Ecklonia and Sargassum. We then model changes in lipid availability in response to climate-driven ocean warming throughout Ecklonia’s eastern Australian distribution. Contrary to expectations, ocean warming and marine heatwaves had limited effects on seaweed nutritional quality, indicating resilience in the nutritional value of these species to climate-driven warming. However, nutritional quality varied significantly between species, which presents new implications for predicted species redistributions from the base of the food chain. Modelling revealed a projected net loss of 3.5% of lipids across the east coast of Australia by 2100 under RCP 8.5 in response to shifts in the redistribution of Ecklonia biomass. The climate-driven redistribution of seaweeds is likely to alter the availability of seaweed-derived nutrients to consumers, which may have broad implications for the transfer of energy within temperate marine food webs.
In vitro and in vivo antimicrobial effects of domiphen combined with itraconazole against Aspergillus fumigatus
Authors: Yang Huan , Gu Yufan , He Zhiqiang , Wu Jia-Nan , Wu Chen , Xie Yuhan , You Yuxin , Yang Yijia , Zhou Xinyu , Liu Yi , Du Wenlong
Published: November 2023

Aspergillus fumigatus, a prevalent saprophytic fungus in the atmosphere, is known to rapidly induce severe invasive aspergillosis (IA) upon inhalation of its conidia by humans or animals. The mortality rate associated with IA exceeds 50%. The misuse of antifungal agents has contributed to the emergence of numerous highly pathogenic drug-resistant strains of A. fumigatus. Our study found that the combination of domiphen and itraconazole had sound synergistic antimicrobial effects against wild-type and itraconazole-resistant A. fumigatus in vivo and in vitro through MIC, FIC, plate inoculation, growth curve experiments, and Galleria mellonella infection model. Drug cytotoxicity and pharmacological tests for acute toxicity assays demonstrated that both itraconazole and domiphen showed minimal cytotoxicity and good biocompatibility. The transcriptome sequencing experiment demonstrated that domiphen exerted a suppressive effect on the expression of various genes, including those involved in drug efflux, redox regulation, and cellular membrane and cell wall remodeling. The present investigation explores the synergistic antimicrobial mechanisms of domiphen and itraconazole, encompassing three key aspects: (i) domiphen inhibited the efflux of itraconazole by reducing the expression of drug efflux-related genes, (ii) the combination has good ability to disrupt the cell membrane and cell wall, (iii) the combination also can remove biofilm more effectively. In summary, the utilization of domiphen as a synergist of itraconazole exhibited disruptive effects on the biofilm, cell wall, and cell membrane of A. fumigatus. This subsequently led to a modified distribution of itraconazole within the fungal organism, ultimately resulting in enhanced antifungal efficacy. The results of this study may provide a new therapeutic strategy for the treatment of IA caused by drug-resistant A. fumigatus.
Mild traumatic brain injury-induced persistent blood–brain barrier disruption is prevented by cyclosporine A treatment in hypertension
Authors: Lendvai-Emmert Dominika , Magyar-Sumegi Zsofia Dina , Hegedus Emoke , Szarka Nikolett , Fazekas Balint , Amrein Krisztina , Czeiter Endre , Buki Andras , Ungvari Zoltan , Toth Peter
Published: November 2023

Introduction

Mild traumatic brain injury (mTBI) and hypertension synergize to induce persistent disruption of the blood–brain barrier (BBB), neuroinflammation and cognitive decline. However, the underlying mechanisms are not known. Cerebral production of Cyclophilin A (CyPA) is induced in hypertension and after TBI, and it was demonstrated to activate the nuclear factor-κB (NF-kB)- matrix-metalloproteinase-9 (MMP-9) pathway in cerebral vessels leading to BBB disruption.

Methods

To test the role of CyPA in mTBI- and hypertension-induced BBB disruption we induced mTBI in normotensive and spontaneously hypertensive rats (SHR), then the animals were treated with cyclosporine A (a specific inhibitor of CyPA production) or vehicle for 7 days. We assessed BBB permeability and integrity, cerebral expression and activity of the CyPA-NF-kB-MMP-9 pathway, extravasation of fibrin and neuroinflammation.

Results

We found that mild TBI induced BBB disruption and upregulation of the CyPA-NF-kB-MMP-9 pathway in hypertension, which were prevented by blocking CyPA. Cyclosporine treatment and preservation of BBB function prevented accumulation of blood-derived fibrin in the brain parenchyma of hypertensive rats after mTBI and reversed increased neuroinflammation.

Discussion

We propose that mTBI and hypertension interact to promote BBB disruption via the CyPA-NF-kB-MMP-9 pathway, and inhibition of cyclophilin production after mTBI may exert neuroprotection and improve cognitive function in hypertensive patients.