bluuebunny/crossref_metadata_2025 huggingface dataset:
The Analysis of WJ Distribution as an Extended Gaussian Function: Case Study
Authors: Ge Shurong , Wu Junhua
Published: August 2022

The double exponential WJ distribution has been shown to competently describe extreme events and critical phenomena, while the Gaussian function has celebrated rich applications in many other fields. Here we present the analysis that the WJ distribution may be properly treated as an extended Gaussian function. Based on the Taylor expansion, we propose three methods to formulate the WJ distribution in the form of Gaussian functions, with Method I and Method III being accurate and self-consistent, and elaborate the relationship among the parameters of the functions. Moreover, we derive the parameter scaling formula of the WJ distribution to express a general Gaussian function, with the work illustrated by a classical case of extreme events and critical phenomena and application to topical medical image processing to prove the effectiveness of the WJ distribution rather than the Gaussian function. Our results sturdily advocate that the WJ distribution can elegantly represent a Gaussian function of arbitrary parameters, whereas the latter usually is not able to satisfactorily describe the former except for specific parameter sets. Thus, it is conclusive that the WJ distribution offers applicability in extreme events and critical phenomena as well as processes describable by the Gaussian function, namely, implying plausibly a unifying approach to the pertinent data processing of those quite distinct areas and establishing a link between relevant extreme value theories and Gaussian processes.
Ranks with Respect to a Projective Variety and a Cost-Function
Authors: Ballico Edoardo
Published: August 2022

Let X⊂Pr be an integral and non-degenerate variety. A “cost-function” (for the Zariski topology, the semialgebraic one, or the Euclidean one) is a semicontinuous function w:=[1,+∞)∪+∞ such that w(a)=1 for a non-empty open subset of X. For any q∈Pr, the rank rX,w(q) of q with respect to (X,w) is the minimum of all ∑a∈Sw(a), where S is a finite subset of X spanning q. We have rX,w(q)<+∞ for all q. We discuss this definition and classify extremal cases of pairs (X,q). We give upper bounds for all rX,w(q) (twice the generic rank) not depending on w. This notion is the generalization of the case in which the cost-function w is the constant function 1. In this case, the rank is a well-studied notion that covers the tensor rank of tensors of arbitrary formats (PARAFAC or CP decomposition) and the additive decomposition of forms. We also adapt to cost-functions the rank 1 decomposition of real tensors in which we allow pairs of complex conjugate rank 1 tensors.
Rotating and Expanding Gas in Binary Post-AGB Stars
Authors: Gallardo Cava Iván , Bujarrabal Valentín , Alcolea Javier , Gómez-Garrido Miguel , Castro-Carrizo Arancha , Van Winckel Hans , Santander-García Miguel
Published: August 2022

There is a class of binary post-AGB stars (binary system including a post-AGB star) that are surrounded by Keplerian disks and outflows resulting from gas escaping from the disk. To date, there are seven sources that have been studied in detail through interferometric millimeter-wave maps of CO lines (ALMA/NOEMA). For the cases of the Red Rectangle, IW Carinae, IRAS 08544-4431, and AC Herculis, it is found that around ≥85% of the total nebular mass is located in the disk with Keplerian dynamics. The remainder of the nebular mass is located in an expanding component. This outflow is probably a disk wind consisting of material escaping from the rotating disk. These sources are the disk-dominated nebulae. On the contrary, our maps and modeling of 89 Herculis, IRAS 19125+0343, and R Scuti, which allowed us to study their morphology, kinematics, and mass distribution, suggest that, in these sources, the outflow clearly is the dominant component of the nebula (∼75% of the total nebular mass), resulting in a new subclass of nebulae around binary post-AGB stars: the outflow-dominated sources.Besides CO, the chemistry of this type of source has been practically unknown thus far. We also present a very deep single-dish radio molecular survey in the 1.3, 2, 3, 7, and 13 mm bands (∼600 h of telescope time). Our results and detections allow us to classify our sources as O- or /C-rich. We also conclude that the calculated abundances of the detected molecular species other than CO are particularly low, compared with AGB stars. This fact is very significant in those sources where the rotating disk is the dominant component of the nebula.
Numerical Simulation of a Giant-Hail-Bearing Mediterranean Supercell in the Adriatic Sea
Authors: Tiesi Alessandro , Mazzà Simone , Conte Dario , Ricchi Antonio , Baldini Luca , Montopoli Mario , Picciotti Errico , Vulpiani Gianfranco , Ferretti Rossella , Miglietta Mario Marcello
Published: August 2022

On 10 July 2019, a giant hail-bearing supercell hit the Adriatic coast of central Italy. Hailstones with a maximum diameter of 14 cm were reported in the city of Pescara between 10:00 and 11:00 UTC. In this work, the main synoptic and mesoscale features, responsible for the triggering and the development of the supercell, are analyzed using the WRF model. The intrusion of Bora wind over the northern and central Adriatic was relevant for two reasons: on the one side, the arrival of low-level cold air produced an uplift of the pre-existing warm air and favored the triggering of convection; on the other side, the strong vertical wind shear, also due to the presence of intense upper-level southwesterlies, created conditions favorable to the formation of the supercell. The predictability of the event is also discussed, comparing simulations starting at different initial times and forced with GFS and IFS forecasts. The model results show that the runs initialized at earlier times reproduced more accurately the track and the time evolution of the supercell. The HAILCAST module of WRF was also used to simulate hailstorm characteristics, such as the average hailstone diameter. WRF-HAILCAST simulations proved to be in fair agreement with the radar reflectivity retrievals and with local reports.
Atmospheric Modelling of Mercury in the Southern Hemisphere and Future Research Needs: A Review
Authors: Leiva González Jorge , Diaz-Robles Luis A. , Cereceda-Balic Francisco , Pino-Cortés Ernesto , Campos Valeria
Published: August 2022

Mercury is a toxic pollutant that can negatively impact the population’s health and the environment. The research on atmospheric mercury is of critical concern because of the diverse process that this pollutant suffers in the atmosphere as well as its deposition capacity, which can provoke diverse health issues. The Minamata Convention encourages the protection of the adverse effects of mercury, where research is a part of the strategies and atmospheric modelling plays a critical role in achieving the proposed aim. This paper reviews the study of modelling atmospheric mercury based on the southern hemisphere (SH). The article discusses diverse aspects focused on the SH such as the spatial distribution of mercury, its emissions projections, interhemispheric transport, and deposition. There has been a discrepancy between the observed and the simulated values, especially concerning the seasonality of gaseous elemental mercury and total gaseous mercury. Further, there is a lack of research about the emissions projections in the SH and mercury deposition, which generates uncertainty regarding future global scenarios. More studies on atmospheric mercury behaviour are imperative to better understand the SH’s mercury cycle.
Impact of Shale Gas Exploration and Exploitation Activities on the Quality of Ambient Air—The Case Study of Wysin, Poland
Authors: Jarosławski Janusz , Pawlak Izabela , Guzikowski Jakub , Pietruczuk Aleksander
Published: August 2022

The continuous two-year monitoring of a set of air pollutants, as well as gases directly related to shale gas exploration processes (methane, non-methane hydrocarbons, carbon dioxide), was carried out at Stary Wiec village in the vicinity (1100 m) of the shale gas wells area in Wysin (Pomeranian voivodeship, north of Poland), covering the stages of preparation, drilling, hydrofracturing and closing of wells. The results of analysis of air pollution data from Stary Wiec and nearby urban and rural stations, over the period 2012–2017 (starting three years before preparations for hydraulic fracturing) indicated that Stary Wiec represents a clean rural environment with an average concentration of nitrogen oxides, carbon monoxide and particulate matter that is one of the lowest in the Pomeranian region. The aim of this study was to explore the range of potential impact of shale gas exploration on local ambient air quality. Analysis of dependence of the concentration level of pollutants on the wind direction indicated that during the drilling period, when the air was coming directly from the area of the wells, nitrogen oxide concentration increased by 13%. Increases of concentration during the hydro-fracturing period, recorded at the Stary Wiec station, were equal to 108%, 21%, 18%, 12%, 7%, 4%, 1% for nitrogen oxide, non-methane hydrocarbons, carbon monoxide, nitrogen dioxide, particulate matter, carbon dioxide and methane. The results of one-minute concentration values for the period 1–4 September 2016 showed a series of short peaks up to 7.45 ppm for methane and up to 3.03 ppm for non-methane hydrocarbons, being probably the result of operations carried out at the area of the wells.
Leading for Innovation: Self-Efficacy and Work Engagement as Sequential Mediation Relating Ethical Leadership and Innovative Work Behavior
Authors: Uppathampracha Rachadatip , Liu Guoxin
Published: August 2022

This research investigated the link between ethical leadership and innovative work behavior by examining the role of self-efficacy as a mediating factor and the sequential mediation of self-efficacy and work engagement. Using a survey approach, data were collected from 441 bank employees in the southern region of Thailand. The findings of the structural equation modeling (SEM) analysis revealed an association between ethical leadership and innovative work behavior and self-efficacy, respectively. Work engagement and innovative work behavior were both linked to self-efficacy. Work engagement was associated with innovative work behavior. According to the mediation analysis results, self-efficacy appeared to mediate the relationship between ethical leadership and innovative work behavior. Ultimately, it was shown that self-efficacy and work engagement were sequentially mediated by ethical leadership and innovative work behavior. This research provides insight into the understanding of the connection between ethical leadership and innovative work behavior. The key contributions of this research are the exploration-mediating function of self-efficacy and the sequential mediation roles of self-efficacy and work engagement.
Management of Superficial Esophageal Squamous Cell Carcinoma and Early Gastric Cancer following Non-Curative Endoscopic Resection
Authors: Hatta Waku , Koike Tomoyuki , Uno Kaname , Asano Naoki , Masamune Atsushi
Published: August 2022

According to the European and Japanese guidelines, additional treatment is recommended for cases of superficial esophageal squamous cell carcinoma (ESCC) and early gastric cancer (EGC) that do not meet the curability criteria for endoscopic resection (ER), i.e., non-curative ER, owing to the risk of lymph node metastasis (LNM). However, the rates of LNM in such cases were relatively low (e.g., 8% for EGC). Several recent advances have been made in this field. First, pathological risk stratification for metastatic recurrence following non-curative ER without additional treatment was developed for both superficial ESCC and EGC. Second, the pattern of metastatic recurrence and prognosis after recurrence following non-curative ER without additional treatment was found to be considerably different between superficial ESCC and EGC. Third, a combination of ER and selective chemoradiotherapy was developed as a minimally invasive treatment method for clinical T1b-SM ESCC. These findings may help clinicians decide the treatment strategy for patients following non-curative ER; however, for optimal therapeutic decision-making in such patients, it is also important to predict the prognosis other than SESCC or EGC and impaired quality of life. Thus, a novel algorithm that considers these factors, as well as metastatic recurrence, should be developed.
Pharmacologic Targeting of MMP2/9 Decreases Peritoneal Metastasis Formation of Colorectal Cancer in a Human Ex Vivo Peritoneum Culture Model
Authors: Koch Jana , Mönch Dina , Maaß Annika , Mangold Alina , Gužvić Miodrag , Mürdter Thomas , Leibold Tobias , Dahlke Marc-H. , Renner Philipp
Published: August 2022

Background: Matrix metalloproteinases (MMPs) play a crucial role in tumour initiation, progression, and metastasis, including peritoneal carcinosis (PC) formation. MMPs serve as biomarkers for tumour progression in colorectal cancer (CRC), and MMP overexpression is associated with advanced-stage metastasis and poor survival. However, the molecular mechanisms of PC from CRC remain largely unclear. Methods: We investigated the role of MMPs during peritoneal colonisation by CRC cell lines in a human ex vivo peritoneum model and in patient-derived CRC and corresponding PC samples. MMP2 and MMP9 were inhibited using the small-molecule inhibitors batimastat and the specific MMP2/9 inhibitor III. Results: MMP2 and MMP9 were strongly upregulated in patient-derived samples and following peritoneal colonisation by CRC cells in the ex vivo model. MMP inhibition with batimastat reduced colonisation of HT29 and Colo205 cells by 36% and 68%, respectively (p = 0.0073 and p = 0.0002), while MMP2/9 inhibitor III reduced colonisation by 50% and 41%, respectively (p = 0.0003 and p = 0.0051). Fibronectin cleavage was enhanced in patient-derived samples of PC and during peritoneal colonisation in the ex vivo model, and this was inhibited by MMP2/9 inhibition. Conclusion: MMPs were upregulated in patient-derived samples and during peritoneal attachment of CRC cell lines in our ex vivo model. MMP2/9 inhibition prevented fibronectin cleavage and peritoneal colonisation by CRC cells. MMP inhibitors might thus offer a potential treatment strategy for patients with PC.
A Proof-of-Concept Inhibitor of Endothelial Lipase Suppresses Triple-Negative Breast Cancer Cells by Hijacking the Mitochondrial Function
Authors: Yang Rongze , Han Shuyan , Clayton Joseph , Haghighatian Mahan , Tsai Cheng-Chieh , Yao Yuan , Li Pingping , Shen Jana , Zhou Qun
Published: August 2022

Triple-negative breast cancer (TNBC) cells reprogram their metabolism to provide metabolic flexibility for tumor cell growth and survival in the tumor microenvironment. While our previous findings indicated that endothelial lipase (EL/LIPG) is a hallmark of TNBC, the precise mechanism through which LIPG instigates TNBC metabolism remains undefined. Here, we report that the expression of LIPG is associated with long non-coding RNA DANCR and positively correlates with gene signatures of mitochondrial metabolism-oxidative phosphorylation (OXPHOS). DANCR binds to LIPG, enabling tumor cells to maintain LIPG protein stability and OXPHOS. As one mechanism of LIPG in the regulation of tumor cell oxidative metabolism, LIPG mediates histone deacetylase 6 (HDAC6) and histone acetylation, which contribute to changes in IL-6 and fatty acid synthesis gene expression. Finally, aided by a relaxed docking approach, we discovered a new LIPG inhibitor, cynaroside, that effectively suppressed the enzyme activity and DANCR in TNBC cells. Treatment with cynaroside inhibited the OXPHOS phenotype of TNBC cells, which severely impaired tumor formation. Taken together, our study provides mechanistic insights into the LIPG modulation of mitochondrial metabolism in TNBC and a proof-of-concept that targeting LIPG is a promising new therapeutic strategy for the treatment of TNBC.
Hydrocephalus in Nfix−/− Mice Is Underpinned by Changes in Ependymal Cell Physiology
Authors: Harkins Danyon , Harvey Tracey J. , Atterton Cooper , Miller Ingrid , Currey Laura , Oishi Sabrina , Kasherman Maria , Davila Raul Ayala , Harris Lucy , Green Kathryn , Piper Hannah , Parton Robert G. , Thor Stefan , Cooper Helen M. , Piper Michael
Published: August 2022

Nuclear factor one X (NFIX) is a transcription factor required for normal ependymal development. Constitutive loss of Nfix in mice (Nfix−/−) is associated with hydrocephalus and sloughing of the dorsal ependyma within the lateral ventricles. Previous studies have implicated NFIX in the transcriptional regulation of genes encoding for factors essential to ependymal development. However, the cellular and molecular mechanisms underpinning hydrocephalus in Nfix−/− mice are unknown. To investigate the role of NFIX in hydrocephalus, we examined ependymal cells in brains from postnatal Nfix−/− and control (Nfix+/+) mice using a combination of confocal and electron microscopy. This revealed that the ependymal cells in Nfix−/− mice exhibited abnormal cilia structure and disrupted localisation of adhesion proteins. Furthermore, we modelled ependymal cell adhesion using epithelial cell culture and revealed changes in extracellular matrix and adherens junction gene expression following knockdown of NFIX. Finally, the ablation of Nfix from ependymal cells in the adult brain using a conditional approach culminated in enlarged ventricles, sloughing of ependymal cells from the lateral ventricles and abnormal localisation of adhesion proteins, which are phenotypes observed during development. Collectively, these data demonstrate a pivotal role for NFIX in the regulation of cell adhesion within ependymal cells of the lateral ventricles.
Profiling Microglia through Single-Cell RNA Sequencing over the Course of Development, Aging, and Disease
Authors: Pettas Spyros , Karagianni Korina , Kanata Eirini , Chatziefstathiou Athanasia , Christoudia Nikoletta , Xanthopoulos Konstantinos , Sklaviadis Theodoros , Dafou Dimitra
Published: August 2022

Microglia are macrophages present in the brain that function as the primary and most important source of immune response in the central nervous system (CNS). Regardless of their multitasking role, our knowledge regarding their molecular heterogeneity is limited; due to technical restrictions, it is only possible to measure gene expression in cell populations, not individual cells, with the results reflecting average mRNA levels. Therefore, recent scientific approaches have focused on single-cell techniques such as single-cell RNA sequencing (scRNAseq), a powerful technique that enables the delineation of transcriptomic cell-to-cell differences, revealing subpopulations with distinct molecular and functional characteristics. Here, we summarize recent studies that focused on transcriptomic microglial subpopulation clustering and classify them into three distinct groups based on age, spatial distribution, and disease. Additionally, we cross-compare populations from different studies to identify expressional and functional overlaps between them.
Oxidation Resistance of γ-TiAl Based Alloys Modified by C, Si and Y2O3 Microdopants
Authors: Loginov Pavel A. , Markov Georgy M. , Shvyndina Nataliya V. , Smirnov Gleb V. , Levashov Evgeny A.
Published: August 2022

This work aimed to study the oxidation resistance of γ-TiAl based alloy, doped with small concentrations of carbon, silicon, and yttrium oxide in air at 800 and 1100 °C for 30 h. The TNM-B1 alloy samples were produced via high-energy ball milling, self-propagating high-temperature synthesis, and hot isostatic pressing techniques. The microstructure, oxidation kinetics at 800–1100 °C, scale structure, and oxidation mechanism were studied. The oxidation of alloys modified with carbon and silicon at 1100 °C was characterized by the formation of a three-layer coating. The Y2O3 modified alloy performed the greatest oxidation resistance at 1100 °C and promoted the formation of a dense Al2O3 interlayer.
An Easy and Reliable Method for the Mitigation of Deuterated Chloroform Decomposition to Stabilise Susceptible NMR Samples
Authors: Teipel Jan , Gottstein Vera , Hölzle Eva , Kaltenbach Katja , Lachenmeier Dirk , Kuballa Thomas
Published: August 2022

Highly reactive decomposition products of deuterated chloroform can deteriorate samples dissolved in this commonly used solvent for nuclear magnetic resonance (NMR) spectroscopy. Samples for metabolomics studies often contain a complex mixture of sensitive substances such as phospholipids, peptides, unsaturated fatty acids or vitamins. If these react with decomposition products (of chloroform), abnormal NMR spectra could result, e.g., signal shifts depending on pH, attenuation of signals over time due to chemical changes of analytes or new signals from reaction products. Such irreproducibly influenced spectra are especially problematic for non-targeted analysis methods using automated chemometrical data evaluation. To prevent these artefacts, chlorine, phosgene and hydrochloric acid need to be eliminated from deuterated chloroform before its use. Since the common stabilisation methods have proven to be insufficient for sensitive NMR samples, another purging method has been tested: Mitigation is easily and reliably achieved by washing the deuterated chloroform with concentrated disodium carbonate solution and subsequent desiccation with oven-dried disodium carbonate.
Effect of Co and Cr on the Stability of Strengthening Phases in Nickelbase Superalloys
Authors: Bäker Martin , Rösler Joachim
Published: August 2022

Nickel-base superalloys such as VDM 780 may possess a high content of Cr and Co. This influences solution energies of phase-forming elements such as Al and Ta (γ′-phase), Nb (γ″- and δ-phase), and Ti (η-phase). We perform density functional theory studies of a nickel matrix at 0 K with high concentrations of either Co and Cr and calculate the influence of these elements on solution energies. In the case of Co, the solution energy can be predicted well by the nearest-neighbor interaction in the Co-rich matrix. For Cr, the effect is more complicated because Cr has a larger ionic radius and changes the magnetic state of the material. The effect of a Cr-rich matrix on the energy of Co is dominated by magnetic effects and interactions with the other elements by elastic deformation of the lattice. A high content of Co or Cr will thus increase the solvus temperature of the strengthening phase in nickel-base superalloys, in agreement with the literature and thermodynamic calculations.
An Efficient Improved Greedy Harris Hawks Optimizer and Its Application to Feature Selection
Authors: Zou Lewang , Zhou Shihua , Li Xiangjun
Published: August 2022

To overcome the lack of flexibility of Harris Hawks Optimization (HHO) in switching between exploration and exploitation, and the low efficiency of its exploitation phase, an efficient improved greedy Harris Hawks Optimizer (IGHHO) is proposed and applied to the feature selection (FS) problem. IGHHO uses a new transformation strategy that enables flexible switching between search and development, enabling it to jump out of local optima. We replace the original HHO exploitation process with improved differential perturbation and a greedy strategy to improve its global search capability. We tested it in experiments against seven algorithms using single-peaked, multi-peaked, hybrid, and composite CEC2017 benchmark functions, and IGHHO outperformed them on optimization problems with different feature functions. We propose new objective functions for the problem of data imbalance in FS and apply IGHHO to it. IGHHO outperformed comparison algorithms in terms of classification accuracy and feature subset length. The results show that IGHHO applies not only to global optimization of different feature functions but also to practical optimization problems.
Investigating Vernal Pool Fairy Shrimp Exposure to Organophosphate Pesticides: Implications for Population-Level Risk Assessment
Authors: Miller David H. , Etterson Matthew , Oliver Leah , Paulukonis Elizabeth , Pollesch Nathan , Purucker S. Thomas , Rogers D. Christopher , Sinnathamby Sumathy , Raimondo Sandy
Published: August 2022

Vernal pool fairy shrimp, Branchinecta lynchi, is a freshwater crustacean endemic to California and Oregon, including California’s Central Valley. B. lynchi is listed as a Federally Threatened species under the US Endangered Species Act, and as a vulnerable species on the IUCN Red List. Threats that may negatively impact vernal pool fairy shrimp populations include pesticide applications to agricultural land use (e.g., agrochemicals such as organophosphate pesticides) and climate changes that impact vernal pool hydrology. Pop-GUIDE (Population model Guidance, Use, Interpretation, and Development for Ecological risk assessment) is a comprehensive tool that facilitates development and implementation of population models for ecological risk assessment and can be used to document the model derivation process. We employed Pop-GUIDE to document and facilitate the development of a population model for investigating impacts of organophosphate pesticides on vernal pool fairy shrimp populations in California’s Central Valley. The resulting model could be applied in combination with field assessment and laboratory-based chemical analysis to link effects from pesticide exposure to adverse outcomes in populations across their range. B. lynchi has a unique intra-annual life cycle that is largely dependent upon environmental conditions. Future deployment of this population model should include complex scenarios consisting of multiple stressors, whereby the model is used to examine scenarios that combine chemical stress resulting from exposure to pesticides and climate changes.
Graphene and Resin Coated Proppant with Electrically Conductive Properties for In-Situ Modification of Shale Oil
Authors: Chen Siyuan , Liu Fanghui , Zhou Yang , Lan Xiuping , Li Shouzhen , Wang Lulu , Xu Quan , Li Yeqing , Jin Yan
Published: August 2022

Proppant is an essential material in hydraulic fracturing, and it can support artificial fractures for a long time. However, few people have applied proppant and conductive materials in the in-situ modification of shale oil. Here, we developed a graphene and resin coated (GRC) proppant with electrically conductive properties. The electrical conductivity of the GRC proppant improved by four orders of magnitude. The GRC proppant has a 54.58% improvement in suspension and 22.75% increase in settlement time at 0.25 wt% concentration compared with uncoated proppant. The GRC proppant’s adhesion reached 68.34 nN under 1 μN load force, increasing by 63.13% compared to uncoated proppant. This new electrically conductive proppant can be used as a conductive carrier to improve the efficiency of electric heating in in-situ modification technology of shale oil.
Analysis of the Operation Characteristics of a Hybrid Heat Pump in an Existing Multifamily House Based on Field Test Data and Simulation
Authors: Neubert Daniel , Glück Christian , Schnitzius Julian , Marko Armin , Wapler Jeannette , Bongs Constanze , Felsmann Clemens
Published: August 2022

Unrenovated multifamily houses in Germany are mostly heated by fossil heat generators; therefore, measures are required for CO2 emission reduction. The use of air–water heat pumps is restricted by high required flow temperatures and heat output but can be mitigated by hybrid heat pumps. To limit additional operation costs by the heat pump, a new operation strategy is introduced in this study, which allows to maintain a target CO2 emission. The operation strategy is applied in a field trial in a small unrenovated multifamily house built in 1964. A thermohydraulic simulation model is verified and is used in full-year simulations to apply improvement measures and compare the new control strategy with existing optimizing strategies. The results show that the control onto target emissions is possible and limits additional costs but can also result in higher CO2 mitigation costs, making it less favorable. The hybrid heat pump reduces the direct fossil CO2 emissions by 61% (in total by 22%); thus, it is a relevant solution for multifamily houses, especially within a further decarbonized electrical grid.
Nucleosome Structures Built from Highly Divergent Histones: Parasites and Giant DNA Viruses
Authors: Sato Shoko , Dacher Mariko , Kurumizaka Hitoshi
Published: August 2022

In eukaryotes, genomic DNA is bound with histone proteins and packaged into chromatin. The nucleosome, a fundamental unit of chromatin, regulates the accessibility of DNA to enzymes involved in gene regulation. During the past few years, structural analyses of chromatin architectures have been limited to evolutionarily related organisms. The amino acid sequences of histone proteins are highly conserved from humans to yeasts, but are divergent in the deeply branching protozoan groups, including human parasites that are directly related to human health. Certain large DNA viruses, as well as archaeal organisms, contain distant homologs of eukaryotic histone proteins. The divergent sequences give rise to unique and distinct nucleosome architectures, although the fundamental principles of histone folding and DNA contact are highly conserved. In this article, we review the structures and biophysical properties of nucleosomes containing histones from the human parasites Giardia lamblia and Leishmania major, and histone-like proteins from the Marseilleviridae amoeba virus family. The presented data confirm the sharing of the overall DNA compaction system among evolutionally distant species and clarify the deviations from the species-specific nature of the nucleosome.
Negative Density Restricts the Coexistence and Spatial Distribution of Dominant Species in Subtropical Evergreen Broad-Leaved Forests in China
Authors: Jiao Jiejie , Wu Chuping , Jiang Bo , Wang Zhigao , Yuan Weigao , Zhu Jinru , Li Tingting , Yang Shaozong , Yao Liangjin
Published: August 2022

Negative densification affects the spatial distribution of species in secondary evergreen broad-leaved forests and is a key mechanism governing species coexistence. We investigated the effects of habitat heterogeneity and density on the spatial distribution of populations of dominant woody species in a secondary evergreen broad-leaved forest in Wuchaoshan using spatial univariate point pattern analyses. This 6 ha forest dynamic monitoring sample area in Hangzhou, China is a typical secondary subtropical evergreen broad-leaved forest. We found (1) a strong effect of habitat heterogeneity that led to the spatial aggregation of dominant species in the plot. Habitat heterogeneity had a strong impact on mature individuals at different life history stages and of different species on a large scale. (2) Negative density dependence (NDD) generally affected spatial distributions of most dominant species and decreased in magnitude with age class. Therefore, different species of subtropical evergreen broad-leaved forests in China have formed unique spatial structures due to their habitat preferences but are generally subjected to density-dependent effects.
CTCF and Its Partners: Shaper of 3D Genome during Development
Authors: Sun Xiaoyue , Zhang Jing , Cao Chunwei
Published: August 2022

The 3D genome organization and its dynamic modulate genome function, playing a pivotal role in cell differentiation and development. CTCF and cohesin, acting as the core architectural components involved in chromatin looping and genome folding, can also recruit other protein or RNA partners to fine-tune genome structure during development. Moreover, systematic screening for partners of CTCF has been performed through high-throughput approaches. In particular, several novel protein and RNA partners, such as BHLHE40, WIZ, MAZ, Aire, MyoD, YY1, ZNF143, and Jpx, have been identified, and these partners are mostly implicated in transcriptional regulation and chromatin remodeling, offering a unique opportunity for dissecting their roles in higher-order chromatin organization by collaborating with CTCF and cohesin. Here, we review the latest advancements with an emphasis on features of CTCF partners and also discuss the specific functions of CTCF-associated complexes in chromatin structure modulation, which may extend our understanding of the functions of higher-order chromatin architecture in developmental processes.
Triangulating the New Frontier of Health Geo-Data: Assessing Tick-Borne Disease Risk as an Occupational Hazard among Vulnerable Populations
Authors: Maxwell Sarah P. , McNeely Connie L. , Brooks Chris , Thomas Kevin
Published: August 2022

Determining interventions to combat disease often requires complex analyses of spatial-temporal data to improve health outcomes. For some vulnerable populations, obtaining sufficient data for related analyses is especially difficult, thus exacerbating related healthcare, research, and public health efforts. In the United States (U.S.), migrant and seasonal workers are especially affected in this regard, with data on health interventions and outcomes largely absent from official sources. In response, this study offers a multi-modal approach that involves triangulating geographically specified health data that incorporate reports on canine tick species, Lyme disease (LD) incidence, and patient symptom severity indicating potential subsequent disease burden. Spatial alignment of data at the U.S. county level was used to reveal and better understand tick-borne disease (TBD) incidence and risk among the identified populations. Survey data from migrant and seasonal workers in Texas were employed to determine TBD risk based on symptoms, occupations, and locations. Respondents who were found to have a higher likelihood of a TBD were also considerably more likely to report the most common symptoms of LD and other TBDs on the Horowitz Multiple Systemic Infectious Disease Syndrome Questionnaire. Those in the highly likely scoring group also reported more poor health and mental health days. Overall, a notable number of respondents (22%) were likely or highly likely to have a TBD, with particular relevance attributed to county of residence and living conditions. Also of note, almost a third of those reporting severe symptoms had received a previous Lyme disease diagnosis. These findings underscore the need for further surveillance among vulnerable populations at risk for TBDs.
Donating Health Data to Research: Influential Characteristics of Individuals Engaging in Self-Tracking
Authors: Pilgrim Katharina , Bohnet-Joschko Sabine
Published: August 2022

Health self-tracking is an ongoing trend as software and hardware evolve, making the collection of personal data not only fun for users but also increasingly interesting for public health research. In a quantitative approach we studied German health self-trackers (N = 919) for differences in their data disclosure behavior by comparing data showing and sharing behavior among peers and their willingness to donate data to research. In addition, we examined user characteristics that may positively influence willingness to make the self-tracked data available to research and propose a framework for structuring research related to self-measurement. Results show that users’ willingness to disclose data as a “donation” more than doubled compared to their “sharing” behavior (willingness to donate = 4.5/10; sharing frequency = 2.09/10). Younger men (up to 34 years), who record their vital signs daily, are less concerned about privacy, regularly donate money, and share their data with third parties because they want to receive feedback, are most likely to donate data to research and are thus a promising target audience for health data donation appeals. The paper adds to qualitative accounts of self-tracking but also engages with discussions around data sharing and privacy.
The Prevalence of Diabetes among Hypertensive Polish in Relation to Sex-Difference in Body Mass Index, Waist Circumference, Body Fat Percentage and Age
Authors: Bednarek Anna Maria , Owczarek Aleksander Jerzy , Chudek Anna , Almgren-Rachtan Agnieszka , Wieczorowska-Tobis Katarzyna , Olszanecka-Glinianowicz Magdalena , Chudek Jerzy
Published: August 2022

Background: Little is known about sex differences in the risk of type 2 diabetes (DM2) development related to body fat depot. The main aim of this study was to assess sex-specific differences in the prevalence of diabetes in the relation to body mass, body mass index (BMI), waist circumference (WC), and calculated body fat percentage (BF), adjusted by physical activity, in younger and older hypertensive adults. Subjects/Methods: The survey enrolled 12,289 adult hypertensive outpatients with body weight, height, and WC reported by their physicians across Poland. Prevalence of diabetes was plotted against body mass, BMI, WC, and calculated BF and adjusted by the self-reported level of physical activity. Results: In our cohort, younger women (<60 years) with BMI < 25.0 kg/m2 had lower adjusted prevalence of diabetes than corresponding men (3.4% vs. 6.5%), while among older (≥60 years) with BMI < 25.0 kg/m2, the prevalence of diabetes was greater in women than in men (19.4% vs. 11.2%). A 25% probability of diabetes was observed for younger women with lower BMI than younger men (32.1 kg/m2 and 35.3 kg/m2, respectively) and WC (100.7 cm and 116.1 cm, respectively) but greater BF (45.5% and 38.9%, respectively). The corresponding differences in BMI and WC in older ones were much smaller (27.6 kg/m2 and 27.2 kg/m2, respectively; 83.7 cm and 85.6 cm, respectively), but not for BF (40.7% and 30.1%, respectively). A doubling of diabetes probability (from 25% to 50%), adjusted by physical activity, was attributable to the lower increase in BMI and WC and BF in women than in men (6.3 vs. 9.8 kg/m2, 25.0 vs. 36.1 cm, and 6.5 vs. 10.8%, for younger, and 8.1 vs. 11.3 kg/m2, 26.2 vs. 73.2 cm and 8.8 vs. 13.3%, for older). Conclusions: This study shows a lower probability of diabetes in younger women than younger men with normal weight BMI ranges, adjusted to physical activity. This probability is greater for hypertensive women, regardless of age, due to the increase in BMI/WC and BF values adjusted for physical activity.
SARS-CoV-2 in Atmospheric Particulate Matter: An Experimental Survey in the Province of Venice in Northern Italy
Authors: Pivato Alberto , Formenton Gianni , Di Maria Francesco , Baldovin Tatjana , Amoruso Irene , Bonato Tiziano , Mancini Pamela , Bonanno Ferraro Giusy , Veneri Carolina , Iaconelli Marcello , Bonadonna Lucia , Vicenza Teresa , La Rosa Giuseppina , Suffredini Elisabetta
Published: August 2022

Analysis of atmospheric particulate matter (PM) has been proposed for the environmental surveillance of SARS-CoV-2. The aim of this study was to increase the current knowledge about the occurrence of SARS-CoV-2 in atmospheric PM, introduce a dedicated sampling method, and perform a simultaneous assessment of human seasonal coronavirus 229E. Thirty-two PM samples were collected on quartz fiber filters and six on Teflon using a low- and high-volumetric rate sampler, respectively, adopting a novel procedure for optimized virus detection. Sampling was performed at different sites in the Venice area (Italy) between 21 February and 8 March 2020 (n = 16) and between 27 October and 25 November 2020 (n = 22). A total of 14 samples were positive for Coronavirus 229E, 11 of which were collected in October–November 2020 (11/22; positivity rate 50%) and 3 in February–March 2020 (3/16 samples, 19%). A total of 24 samples (63%) were positive for SARS-CoV-2. Most of the positive filters were collected in October–November 2020 (19/22; positivity rate, 86%), whereas the remaining five were collected in February–March 2020 at two distinct sites (5/16, 31%). These findings suggest that outdoor PM analysis could be a promising tool for environmental surveillance. The results report a low concentration of SARS-CoV-2 in outdoor air, supporting a scarce contribution to the spread of infection.
Health Care Providers’ Perspectives on Promoting Physical Activity and Exercise in Health Care
Authors: Pellerine Liam P. , O’Brien Myles W. , Shields Chris A. , Crowell Sandra J. , Strang Robert , Fowles Jonathon R.
Published: August 2022

Health care providers (HCPs) are entrusted with providing credible health-related information to their patients/clients. Patients/clients who receive physical activity and exercise (PAE) advice from an HCP typically increase their PAE level. However, most HCPs infrequently discuss PAE or prescribe PAE, due to the many challenges (e.g., time, low confidence) they face during regular patient care. The purpose of this study was to ascertain HCPs’ perspectives of what could be done to promote PAE in health care. HCPs (n = 341) across Nova Scotia completed an online self-reflection survey regarding their current PAE practices and ideas to promote PAE. The sample consisted of 114 physicians, 114 exercise professionals, 65 dietitians, and 48 nurses. Quantitative textual analysis (frequency of theme ÷ number of respondents) was performed to identify common themes to promote PAE in health care. In the pooled sample, the primary theme cited was to increase the availability of community programs (24.1% of respondents), followed by more educational opportunities for providers (22.5%), greater promotion of PAE from HCPs (17.1%), reducing financial barriers experienced by patients/clients (16.3%), and increasing availability of qualified exercise professionals (15.0%). Altogether, increased PAE education and greater availability of affordable community PAE programs incorporating qualified exercise professionals, would reduce barriers preventing routine PAE promotion and support the promotion of PAE in Nova Scotia.
Experimental Analysis of Temperature-Control Curtain Regulating Outflow Temperature in a Thermal-Stratified Reservoir
Authors: Liu Chunxi , Lian Jijian , Wang Haijun
Published: August 2022

The construction of reservoir dams has changed the environment and natural properties of the river course, and deep-water reservoirs present an obvious phenomenon of thermal stratification. Low-temperature outflow water in spring and summer will have a negative impact on the downstream ecological environment. Therefore, it is necessary to take selective withdrawal measures to regulate low-temperature outflow water. The temperature-control curtain project has the advantages of low cost, convenient construction and wide application. Based on the topographic data, a laboratory test model for regulating outflow temperature by a temperature-control curtain is established. A high-power electric heating system is adopted to form a nonlinear thermal stratification. The accuracy of the test data is verified by the prototype observed water temperature. The main parameters affecting the outflow temperature are investigated, including thermal stratification, flow height above the temperature-control curtain, water level, and discharge flow. The results show the following: firstly, the outflow temperature mainly depends on the thermal stratification, decreases with the increase of water level, and increases with the increase of discharge flow; secondly, the effect of a temperature-control curtain on improving the outflow temperature is directly related to the thermal stratification in different months, and the improvement effect is better in spring and summer; finally, the improvement effect increases with the decrease of flow height above the temperature-control curtain, increases with the increase of water level, and decreases with the increase of discharge flow.
Predictors of Gaming Disorder or Protective from It, in a French Sample: A Symptomatic Approach to Self-Regulation and Pursued Rewards, Providing Insights for Clinical Practice
Authors: Achab Sophia , Rothen Stephane , Giustiniani Julie , Nicolier Magali , Franc Elizabeth , Zullino Daniele , Mauny Frederic , Haffen Emmanuel
Published: August 2022

Gaming disorder (GD) is a new health condition still requiring a lot of evidence established around its underlying and related psychological mechanisms. In our study we focused on Massively Multiplayer Online Role Playing Games (MMORPGs), a specific very popular and engaging game genre, to determine that benefit, motivation and control aspects could be predictive of a dysfunctional engagement in gaming. In total, 313 participants were recruited from private forums of gamers between May 2009 and March 2010. They filled out a questionnaire on their socio-demographic data and their weekly gaming time. They also completed different psychometric assessments such as the DSM IV-TR criteria for substance dependence adapted to gaming such as the Dependence Adapted Scale (DAS), the external rewards they expected from gaming (External Motives), the expected internal reward they expected from gaming (Internal Motives), the Zuckerman Sensation Seeking Scale (ZSSS), and the Barratt impulsiveness Scale (BIS-10). Results showed that some psychological factors related to online gaming represented risk factors for GD in participants (i.e., competition and advancement motives, reduced anxiety, solace, greater personal satisfaction, and sense of power), whereas some others were found to be protective factors from GD (i.e., recreation, enjoyment and experience seeking) in participants. Additionally, the study found that disinhibition, boredom susceptibility, thrill and adventure seeking, and high impulsivity were correlated to GD in participants. In conclusion, not only motives for gaming and impulsivity could be predictors for GD, but maladaptive coping strategies based on experienced relief in-game from negative feelings (anxiety and boredom) or experienced improvement in-game of self-perception (personal satisfaction, sense of power) could play as well a role of negative reinforcers for GD. Some benefits from gaming, typically entertainment and enjoyment, are shown to be protective factors from GD, playing the role of positive reinforcing factors. They are worthy of being identified and promoted as functional gaming habits. These findings can feed the clinical and health promotion fields, with a more in-depth understanding of diverse psychological factors in gamers, identifying those at risk for GD and those protective from it. The current work can foster a more balanced approach towards gaming activities, taking their opportunities for mankind and controlling for their adverse effects in some individuals.