bluuebunny/crossref_metadata_2025 huggingface dataset:
Limited-Distance Pollen Dispersal and Low Paternal Diversity in a Bird-Pollinated Self-Incompatible Tree
Authors: Xiang Wen-Qian , Malabrigo Pastor L. , Tang Liang , Ren Ming-Xun
Published: February 2022

Bird pollination in Asia is regarded as an uncommon phenomenon and, therefore, only a few investigations on mating pattern and paternity in fruits of Asian bird-pollinated plants have been conducted. Here, we examined spatial genetic structure, pollen dispersal, and multiple paternity in a natural population of Bombax ceiba (B. ceiba) (Malvaceae) in Hainan Island, South China, using simple sequence repeat (SSR) markers. A low genetic diversity (He = 0.351 ± 0.0341 and 0.389 ± 0.043, respectively, for adults and offspring) and bottleneck effects were observed. Genetic kinship was significant within 400 m or in 1,800–3,800 m. Both the mating pattern and paternity analysis confirmed obligate xenogamy and a low multiple paternity in B. ceiba. There was a strongly negative relationship between the frequency of matings and the distance between mating pairs. The average pollen dispersal distance was 202.89 ± 41.01 m (mean ± SE) and the farthest distance of > 1 km was recorded. Realized mating events showed an extremely leptokurtic distribution within 1,200 m, suggesting that the pollen dispersal distance was consistent with the optimal foraging theory of generalist birds such as Zosterops spp. and Pycnonotus spp. Paternity per tree ranged from two to six and the average effective number of pollen donors per maternal plant was 3.773, suggesting a low level of paternity diversity as compared to other bird-pollinated plants. We concluded that optimal foraging behavior by generalist birds could explain the leptokurtic pollen dispersal distribution and predominantly near-neighbor matings in B. ceiba. The limited pollen dispersal distance and low multiple paternity were consistent with low fruit setting rate (3.27 ± 0.93%) in this self-incompatible tree, which was caused mainly by the restricted flight distance of birds and human disturbances. Low genetic diversity and significant spatial genetic structure might have largely resulted from logging and human collection of fruits.
Multi-Approach Analysis Reveals Pathways of Cold Tolerance Divergence in Camellia japonica
Authors: Fan MengLong , Zhang Ying , Li XinLei , Wu Si , Yang MeiYing , Yin Hengfu , Liu Weixin , Fan Zhengqi , Li Jiyuan
Published: February 2022

Understanding the molecular mechanism of the cold response is critical to improve horticultural plant cold tolerance. Here, we documented the physiological, transcriptome, proteome, and hormonal dynamics to cold stress in temperate genotype (Tg) and subtropical genotype (Sg) populations of Camellia japonica. Tg C. japonica suffered minimal osmotic and oxidative damage compared to Sg C. japonica under the same cold treatment. Transcriptional and translational differences increased under the cold treatment, indicating that Tg C. japonica was affected by the environment and displayed both conserved and divergent mechanisms. About 60% of the genes responding to cold had similar dynamics in the two populations, but 1,896 transcripts and 455 proteins differentially accumulated in response to the cold between Tg and Sg C. japonica. Co-expression analysis showed that the ribosomal protein and genes related to photosynthesis were upregulated in Tg C. japonica, and tryptophan, phenylpropanoid, and flavonoid metabolism were regulated differently between the two populations under cold stress. The divergence of these genes reflected a difference in cold responsiveness. In addition, the decrease in the abscisic acid (ABA)/gibberellic acid (GA) ratio regulated by biosynthetic signal transduction pathway enhanced cold resistance in Tg C. japonica, suggesting that hormones may regulate the difference in cold responsiveness. These results provide a new understanding of the molecular mechanism of cold stress and will improve cold tolerance in horticultural plants.
Using Unmanned Aerial Vehicle-Based Multispectral Image Data to Monitor the Growth of Intercropping Crops in Tea Plantation
Authors: Shi Yujie , Gao Yuan , Wang Yu , Luo Danni , Chen Sizhou , Ding Zhaotang , Fan Kai
Published: February 2022

Aboveground biomass (AGB) and leaf area index (LAI) are important indicators to measure crop growth and development. Rapid estimation of AGB and LAI is of great significance for monitoring crop growth and agricultural site-specific management decision-making. As a fast and non-destructive detection method, unmanned aerial vehicle (UAV)-based imaging technologies provide a new way for crop growth monitoring. This study is aimed at exploring the feasibility of estimating AGB and LAI of mung bean and red bean in tea plantations by using UAV multispectral image data. The spectral parameters with high correlation with growth parameters were selected using correlation analysis. It was found that the red and near-infrared bands were sensitive bands for LAI and AGB. In addition, this study compared the performance of five machine learning methods in estimating AGB and LAI. The results showed that the support vector machine (SVM) and backpropagation neural network (BPNN) models, which can simulate non-linear relationships, had higher accuracy in estimating AGB and LAI compared with simple linear regression (LR), stepwise multiple linear regression (SMLR), and partial least-squares regression (PLSR) models. Moreover, the SVM models were better than other models in terms of fitting, consistency, and estimation accuracy, which provides higher performance for AGB (red bean: R2 = 0.811, root-mean-square error (RMSE) = 0.137 kg/m2, normalized RMSE (NRMSE) = 0.134; mung bean: R2 = 0.751, RMSE = 0.078 kg/m2, NRMSE = 0.100) and LAI (red bean: R2 = 0.649, RMSE = 0.36, NRMSE = 0.123; mung bean: R2 = 0.706, RMSE = 0.225, NRMSE = 0.081) estimation. Therefore, the crop growth parameters can be estimated quickly and accurately using the models established by combining the crop spectral information obtained by the UAV multispectral system using the SVM method. The results of this study provide valuable practical guidelines for site-specific tea plantations and the improvement of their ecological and environmental benefits.
The Transcriptional Corepressor HOS15 Mediates Dark-Induced Leaf Senescence in Arabidopsis
Authors: Zareen Shah , Ali Akhtar , Lim Chae Jin , Khan Haris Ali , Park Junghoon , Xu Zheng-Yi , Yun Dae-Jin
Published: February 2022

Multiple endogenous and environmental signals regulate the intricate and highly complex processes driving leaf senescence in plants. A number of genes have been identified in a variety of plant species, including Arabidopsis, which influence leaf senescence. Previously, we have shown that HOS15 is a multifunctional protein that regulates several physiological processes, including plant growth and development under adverse environmental conditions. HOS15 has also been reported to form a chromatin remodeling complex with PWR and HDA9 and to regulate the chromatin structure of numerous genes. However, unlike PWR and HDA9, the involvement of HOS15 in leaf senescence is yet to be identified. Here, we report that HOS15, together with PWR and HDA9, promotes leaf senescence via transcriptional regulation of SAG12/29, senescence marker genes, and CAB1/RCBS1A, photosynthesis-related genes. The expression of ORE1, SAG12, and SAG29 was downregulated in hos15-2 plants, whereas the expression of photosynthesis-related genes, CAB1 and RCBS1A, was upregulated. HOS15 also promoted senescence through dark stress, as its mutation led to a much greener phenotype than that of the WT. Phenotypes of double and triple mutants of HOS15 with PWR and HDA9 produced phenotypes similar to those of a single hos15-2. In line with this observation, the expression levels of NPX1, APG9, and WRKY57 were significantly elevated in hos15-2 and hos15/pwr, hos15/hda9, and hos15/pwr/hda9 mutants compared to those in the WT. Surprisingly, the total H3 acetylation level decreased in age-dependent manner and under dark stress in WT; however, it remained the same in hos15-2 plants regardless of dark stress, suggesting that dark-induced deacetylation requires functional HOS15. More interestingly, the promoters of APG9, NPX1, and WRKY57 were hyperacetylated in hos15-2 plants compared to those in WT plants. Our data reveal that HOS15 acts as a positive regulator and works in the same repressor complex with PWR and HDA9 to promote leaf senescence through aging and dark stress by repressing NPX1, APG9, and WRKY57 acetylation.
Perturbations in the Carotenoid Biosynthesis Pathway in Tomato Fruit Reactivate the Leaf-Specific Phytoene Synthase 2
Authors: Karniel Uri , Adler Berke Nastacia , Mann Varda , Hirschberg Joseph
Published: February 2022

The accumulation of the red carotenoid pigment lycopene in tomato (Solanum lycopersicum) fruit is achieved by increased carotenoid synthesis during ripening. The first committed step that determines the flux in the carotenoid pathway is the synthesis of phytoene catalyzed by phytoene synthase (PSY). Tomato has three PSY genes that are differentially expressed. PSY1 is exclusively expressed in fruits, while PSY2 mostly functions in green tissues. It has been established that PSY1 is mostly responsible for phytoene synthesis in fruits. Although PSY2 is found in the chromoplasts, it is inactive because loss-of-function mutations in PSY1 in the locus yellow flesh (r) eliminate carotenoid biosynthesis in the fruit. Here we demonstrate that specific perturbations of carotenoid biosynthesis downstream to phytoene prior and during the transition from chloroplast to chromoplast cause the recovery of phytoene synthesis in yellow flesh (r) fruits without significant transcriptional changes of PSY1 and PSY2. The recovery of carotenoid biosynthesis was abolished when the expression of PSY2 was silenced, indicating that the perturbations of carotenoid biosynthesis reactivated the chloroplast-specific PSY2 in fruit chromoplasts. Furthermore, it is demonstrated that PSY2 can function in fruit chromoplasts under certain conditions, possibly due to alterations in the plastidial sub-organelle organization that affect its association with the carotenoid biosynthesis metabolon. This finding provides a plausible molecular explanation to the epistasis of the mutation tangerine in the gene carotenoid isomerase over yellow flesh.
The Effect of Religiosity on Pro-environmental Behavior Based on the Theory of Planned Behavior: A Cross-Sectional Study Among Iranian Rural Female Facilitators
Authors: Karimi Saeid , Liobikienė Genovaitė , Alitavakoli Fatemeh
Published: February 2022

Religiosity is one of the most prominent and extensive social factors influencing one’s behavior; however, there is a lack of research analyzing the religiosity impact on pro-environmental behavior, particularly for women in rural areas. To narrow the research gap, this study established a theoretical research model by incorporating religiosity into the Theory of Planned Behavior to explore factors affecting rural female facilitators’ pro-environmental behavior. The extended Theory of Planned Behavior model was consequently tested by empirical data collected from 110 rural female facilitators in Qom Province in the center of Iran. The results of structural equation modeling indicated that subjective norms and environmental attitude were positively and significantly related to pro-environmental intentions. In addition, pro-environmental intentions and perceived behavioral control were found to be significantly associated with pro-environmental behaviors. The results revealed that there was a direct and indirect relationship between religiosity and pro-environmental behaviors via perceived behavioral control. In addition, there was an indirect relationship between religiosity and pro-environmental intentions via subjective norms and environmental attitudes. Therefore, this study revealed that religiosity as social pressure plays an important role in determining pro-environmental intentions and behaviors among rural female facilitators in Iran. Thus, in order to promote pro-environmental behavior, the religiosity aspects should be considered and people should be stimulated to act in a more environmentally friendly mode via religious prism.
Psycho-Oncological Intervention Through Counseling in Patients With Differentiated Thyroid Cancer in Treatment With Radioiodine (COUNTHY, NCT05054634): A Non-randomized Controlled Study
Authors: Javaloyes Nuria , Crespo Aurora , Redal M. Carmen , Brugarolas Antonio , Botella Lara , Escudero-Ortiz Vanesa , Sureda Manuel
Published: February 2022

Background

Diagnosis and treatment of differentiated thyroid carcinomas (DTC) cause anxiety and depression. Additionally, these patients suffer hormonal alterations that are associated with psychological symptoms (e.g., changes in mood, emotional instability, and memory loss). This study aims to evaluate the effectiveness of a psycho-oncological intervention based on counseling to reduce anxiety and depression related to the treatment in patients with DTC.

Methods

A non-randomized controlled study, with two groups [experimental group (EG), n = 37, and control group (CG), n = 38] and baseline and posttreatment measures, was designed. Patients in the EG received a psycho-oncological intervention based on counseling in addition to the standard treatment. The independent variable was the assigned group and the dependent one was the evolution of anxiety and depression, which were analyzed separately, and both were evaluated using the Hospital Anxiety and Depression Scale. Other relevant covariables related to the quality of life (QoL) were also analyzed using Short Form-36 Health Survey and Psychological General Wellbeing Index scales.

Results

The difference of the posttreatment-baseline variation showed a statistically significant reduction in anxiety and depression in the EG in relation to the CG (p < 0.001). The mean of the Psychological General Wellbeing Index scales score increased significantly in the EG (p < 0.001) and decreased significantly in the CG (p < 0.001). All the baseline and the posttreatment scores of the variables evaluated showed a statistically significant improvement in the EG vs. the CG.

Conclusion

This study demonstrates significant benefits of psycho-oncological intervention based on counseling in anxiety, depression, QoL, and wellbeing of the patient with differentiated thyroid carcinomas.
Entrepreneurial Passion and Entrepreneurial Success—The Role of Psychological Capital and Entrepreneurial Policy Support
Authors: Hu Wei , Xu Yan , Zhao Fuqiang , Chen Yun
Published: February 2022

Entrepreneurship success is the ultimate goal pursued by entrepreneurs, and entrepreneurial passion is also considered an indispensable and important element on the road to entrepreneurial success. However, the internal influence mechanism of entrepreneurial passion on entrepreneurial success is still insufficient in academic circles. In view of this, based on the theory of social information processing, this research analyses the internal mechanism of entrepreneurial passion through individual psychological capital on entrepreneurial success and the promotion of external entrepreneurial policy support. Through a multi-time and multi-source questionnaire survey of 455 entrepreneurs in entrepreneurship parks and entrepreneurship centers in Wuhan, Guangdong, Shanghai, and other places, the research results show that entrepreneurial passion can increase individual psychological capital and positively affect entrepreneurial success; psychological capital mediates the relationship between individual entrepreneurial passion and entrepreneurial success. Entrepreneurship policy support at the environmental level can promote the effect of entrepreneurial passion on the accumulation of psychological capital, and promote the transformation of entrepreneurial passion into entrepreneurial success through psychological capital. The above research results are helpful to the accumulation of entrepreneurs’ psychological capital and provide a useful reference for entrepreneurial success.
Perceived Overqualification and Intensive Smartphone Use: A Moderated Mediation Model
Authors: Peng Xiongliang , Yu Kun , Zhang Kairui , Xue Hanbing , Peng Jianfeng
Published: February 2022

Previous studies only considered the impact of personal or environmental factors on intensive smartphone use separately, while largely ignoring the impact of person-environment (P-E) fit on it. Drawing on the P-E fit theory, we proposed that perceived overqualification (POQ), an indicator of person-job misfit, positively affects intensive smartphone use via job boredom, and affective commitment moderates this indirect effect. We examined our hypotheses using four-wave time-lag data of 450 workers from 62 teams. The results revealed that POQ raised job boredom of an individual and thus increased their intensive smartphone use. In addition, when the affective commitment was high, the indirect effect from POQ to intensive smartphone use via job boredom was weaker. The implications, limitations, and future directions of this research were discussed.
Childhood Experiences and Psychological Distress: Can Benevolent Childhood Experiences Counteract the Negative Effects of Adverse Childhood Experiences?
Authors: Hou Hao , Zhang Caochen , Tang Jie , Wang Jingjing , Xu Jiaqi , Zhou Qin , Yan Wenjun , Gao Xiuyin , Wang Wei
Published: February 2022

Background

Childhood experiences can exert a huge impact on adult psychological conditions. Previous studies have confirmed the effects of adverse childhood experiences (ACEs) and benevolent childhood experiences (BCEs) on psychological distress (e.g., stress, depression, and suicidal ideation) separately, but few studies explored a combined effect of ACEs and BCEs on psychological distress. The aim of this study was to explore a combined effect of ACEs and BCEs on psychological distress among Chinese undergraduates.

Methods

Participants were undergraduates aged 17–24 years (N = 1,816) and completed a self-reported questionnaire. A series of regression analyses were conducted to examine the association between childhood experiences and psychological distress.

Results

A total of 65.7% of undergraduates had BCEs, 27.1% of undergraduates had ACEs, and 12.9% of undergraduates had ACEs and BCEs simultaneously. Logistic regression analysis indicated that undergraduates who experienced high ACEs were more likely to have a high risk of psychological distress [odds ratio (ORs) = 1.46, 1.84, and 3.15 for uncertainty stress, depressive symptoms, and suicidal ideation, respectively], while undergraduates who experienced High BCEs were less likely to have psychological distress (ORs = 0.33, 0.22, and 0.32 for uncertainty stress, depressive symptoms, and suicidal ideation, respectively) compared with Low-Both group. The combined effect of ACEs and BCEs (High-Both group) could also play as a protective factor in uncertainty stress (OR = 0.56) and depressive symptoms (OR = 0.47).

Conclusion

Our findings suggested that ACEs and BCEs could not only predict the psychological distress independently, but also BCEs could counteract the negative effect of ACEs in psychological problems. There is an even greater need to identify and support the victims of ACEs and to increase BCEs in early childhood.
The Influence of Different Learning Strategies on Pupils’ Learning Motivation: Is Augmented Reality Multimedia Learning Consistent With Traditional Text Learning?
Authors: Zhao Xiaojun , Liu Miaozhuang , Liu Yaqing
Published: February 2022

How to reduce pupils’ burden and improve learning efficiency? Research shows that non-intelligence factors and learning strategies are the key factors in the effective learning process, and external intervention can play a greater role in these two aspects. The purpose of this study is to explore the effects of different learning strategies on learning motivation under the presentation of augmented reality (AR) multimedia or traditional text learning. Sixty third-grade pupils in Hebei Province were selected, and 2 (learning materials: AR materials and text materials) × 3 (learning strategies: restudying strategies, retrieval practicing strategies, and self-generated drawing strategies) between-subjects design was adopted. The dependent variable is learning motivation, which includes three dimensions: surface motivation, deep motivation and achievement motivation. The results showed that (1) Learning strategies had a significant impact on deep motivation. The deep motivation aroused by retrieval practicing strategies was significantly higher than that aroused by restudying strategies and self-generated drawing strategies. (2) The interaction between learning materials and learning strategies was marginally significant. When learning with AR materials, the achievement motivation of pupils in the restudying strategy group was higher (marginal significant) than that in the retrieval practicing strategy group. Retrieval practicing strategies have positive significance in cultivating deep motivation. The combination of different learning modes and learning strategies will impact achievement motivation.
Long-Term Mating Orientation in Men: The Role of Socioeconomic Status, Protection Skills, and Parenthood Disposition
Authors: Fajardo Gabriela , Polo Pablo , Muñoz-Reyes José Antonio , Rodríguez-Sickert Carlos
Published: February 2022

From an evolutionary perspective, phenotypic, social, and environmental factors help to shape the different costs and benefits of pursuing different reproductive strategies (or a mixture of them) from one individual to another. Since men’s reproductive success is mainly constrained to women’s availability, their mating orientations should be partially calibrated by features that women prefer in a potential partner. For long-term relationships, women prefer traits that signal access to resources, protection skills, and the willingness to share them. Using generalized linear models with laboratory data taken from a Chilean population (N = 197), this study aimed to test whether real and potential resources (measured as self-reported socioeconomic status), protection skills (measured as handgrip strength), and the willingness to provide resources and protection (measured as their disposition toward parenthood) are related to mating orientation in men. Our predictions were: (1) socioeconomic status would be positively associated with long-term and short-term mating orientation but for long-term-oriented individuals, this would be enhanced by having a more favorable parenthood disposition and (2) strength would be positively related to long-term mating orientation in men with higher socioeconomic status and a favorable disposition toward parenthood and it would have a positive and direct association with short-term mating orientation. Our results partially supported the first hypothesis, since men with higher socioeconomic status were more long-term oriented, but parenting disposition did not moderate this effect. Contrary to our expectations, socioeconomic status was not related to short-term mating orientation. Strength appeared not to be significant for long-term mating orientation, even interacting with other traits. However, strength by itself was powerfully linked with a short-term mating orientation. Our results suggest that only some individuals that are attractive for long-term relationships are indeed long-term oriented and may reflect the overall conflict of interests between mating strategies among sexes.
Socioemotional Resources and Mental Health in Moroccan Adolescents: A Person-Centered Approach
Authors: Pulido-Martos Manuel , Cortés-Denia Daniel , El Ghoudani Karima , Luque-Reca Octavio , Lopez-Zafra Esther
Published: February 2022

Mixture modeling technics are not the one and only to perform person-centered analyses, but they do offer the possibility of integrating latent profiles into models of some complexity that include antecedents and results. When analyzing the contribution of socioemotional resources to the preservation of mental health, it is the variable-centered approaches that are the most often performed, with few examples using a person-centered approach. Moreover, if the focus is on the Arab adolescent population, to our knowledge, there is an absence of such studies. This study aims to extend the research about socioemotional resources by examining: (1) if distinguishable profiles can be identified based on scores about perceptions of different emotional abilities and levels of social support from different sources (e.g., parents, friends, and teachers/counselors); (2) if the identified profiles relate to mental health indicators, such as depression levels and health-related quality of life (HRQoL); and (3) to acknowledge if sociodemographic variables such as age or gender and positive self-views (self-esteem) ascertain the probability of pertaining to the identified profiles. The study was carried out on a large sample of Moroccan adolescents (N = 970). We adopted a person-centered approach using latent profile analysis (LPA) to establish whether different socioemotional resources profiles (e.g., emotional intelligence and social support) are present in Moroccan adolescents. Furthermore, we investigated the role of sociodemographic variables and self-esteem as antecedents of these profiles and the association of these profiles with mental health (depression and HRQoL). Results from LPA revealed three patterns of socioemotional resources (i.e., latent profiles): (1) “High socioemotional resources” (43.09%); (2) “Moderate socioemotional resources” (42.68%); and (3) “Low socioemotional resources” (14.23%). Analyses showed that Moroccan adolescents differed significantly in depression (cognitive-affective and somatic dimensions) and HRQoL depending on the profile membership. Profiles with higher levels of resources contributed positively to preserving mental health. Finally, the results show that self-esteem boosted the probability of pertaining to the profiles related to better mental health. Thus, this study extends previous research about socioemotional resources, highlighting that researchers and health professionals should consider empirically identified profiles of adolescents when explaining mental health outcomes. Therefore, the psychological intervention should be focused on enhancing the self-esteem of adolescents, to favor a high socioemotional resource profile, which results in better mental health.
The Joint Effects of Hubris, Growth Aspirations, and Entrepreneurial Phases for Innovative Behavior
Authors: Poblete Carlos
Published: February 2022

Innovation is often seen as essential for ventures to succeed. High business failure rates in entrepreneurship, however, suggest that innovations are frequently driven by entrepreneurs blinded by overconfidence. Thus, anticipating when and why entrepreneurs will be motivated to innovate is fundamental for entrepreneurial success. Using a large sample obtained from population surveys conducted in 77 countries, this study analyzes the variables that are significantly associated with innovative behaviors. The research tests a model proposing that the joint effects of hubris, growth aspirations, and an entrepreneur’s level of entrepreneurial experience have a crucial impact on innovative endeavors. It finds that hubris is significantly related to entrepreneurs’ growth aspirations and that ambition, in turn, is positively related to innovative behaviors. In addition, the study finds that both relationships are moderated by the level of entrepreneurial experience. These findings highlight the need to wise up amateur entrepreneurs before they embark on innovative endeavors.
Teleworking Impact on Wellbeing and Productivity: A Cluster Analysis of the Romanian Graduate Employees
Authors: Catană Ştefan-Alexandru , Toma Sorin-George , Imbrişcă Cosmin , Burcea Marin
Published: February 2022

The COVID-19 pandemic has already had an enormous impact on numerous aspects of human society such as health, education, economy, business, or work and created favorable conditions for the expansion of teleworking. The aim of the paper is to identify and analyze five teleworking impact factors that affect thewellbeing and productivity of employees. The data were gathered by a quantitative research method through a questionnaire applied to 327 Romanian employees who hold a Bachelor or Master degree. Firstly, they were analyzed and interpreted through a factorial analysis focusing on the five teleworking impact factors. Secondly, the authors carried on cluster analysis, followed by multiple linear regression, using R statistical software. This study shows that there is a plethora of factors that influence the wellbeing and productivity of employees: individual and societal factors, organizational and work-related factors, technological factors, social factors at home, and social factors at work. Also, the cluster analysis brings to light significant differences between various Romanian employees such as: their gender, income, age, education, and city size.
Case Report: Pharmacogenetics Applied to Precision Psychiatry Could Explain the Outcome of a Patient With a New CYP2D6 Genotype
Authors: Marcos-Vadillo Elena , Carrascal-Laso Lorena , Ramos-Gallego Ignacio , Gaedigk Andrea , García-Berrocal Belén , Mayor-Toranzo Eduardo , Sevillano-Jiménez Alfonso , Sánchez Almudena , Isidoro-García María , Franco-Martín Manuel
Published: February 2022

Precision medicine applied to psychiatry provides new insight into the promising field of precision psychiatry. Psychotic disorders are heterogeneous, complex, chronic, and severe mental disorders. Not only does the prognosis and the course of the disease vary among patients suffering from psychotic disorders, but the treatment response varies as well. Although antipsychotic drugs are the cornerstone of the treatment of schizophrenia, many patients only partially respond to these drugs. Furthermore, patients often experience adverse events which can lead to poor treatment adherence. Interindividual variability in drug response could be related to age, gender, ethnicity, lifestyle factors, pharmacological interactions, obesity, and genetics, all of which influence the process of drug metabolism. Commonly prescribed antipsychotics are metabolized by cytochrome P450 (CYP450) enzymes, and CYP450 genes are highly polymorphic. Pharmacogenetic testing is increasingly being used to predict a patient's drug response and could help to find the most appropriate therapy for an individual patient. In this report, we describe a psychotic patient who did not receive adequate clinical follow-up and subsequently presented adverse events, which could be explained by his pharmacogenetic profile and the drug interactions resulting from the polypharmacy prescribed.
Lower Levels of GABAergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the sgACC of Human Subjects With Depression
Authors: Oh Hyunjung , Newton Dwight , Lewis David , Sibille Etienne
Published: February 2022

Rationale

A previous transcriptome meta-analysis revealed significantly lower levels of corticotropin-releasing hormone (CRH) mRNA in corticolimbic brain regions in major depressive disorder (MDD) subjects, suggesting that cortical CRH-expressing (CRH+) cells are affected in MDD. Rodent studies show that cortical CRH is mostly expressed in GABAergic interneurons; however, the characteristic features of CRH+ cells in human brain cortex and their association with MDD are largely unknown.

Methods

Subgenual anterior cingulate cortex (sgACC) of human subjects without brain disorders were labeled using fluorescent in situ hybridization (FISH) for CRH and markers of excitatory (SLC17A7), inhibitory (GAD1) neurons, as well as markers of other interneuron subpopulations (PVALB, SST, VIP). MDD-associated changes in CRH+ cell density and cellular CRH expression (n = 6/group) were analyzed. RNA-sequencing was performed on sgACC CRH+ interneurons from comparison and MDD subjects (n = 6/group), and analyzed for group differences. The effect of reduced BDNF on CRH expression was tested in mice with blocked TrkB function.

Results

About 80% of CRH+ cells were GABAergic and 17.5% were glutamatergic. CRH+ GABAergic interneurons co-expressed VIP (52%), SST (7%), or PVALB (7%). MDD subjects displayed lower CRH mRNA levels in GABAergic interneurons relative to comparison subjects without changes in cell density. CRH+ interneurons show transcriptomic profile suggesting lower excitability and less GABA release and reuptake. Further analyses suggested that these molecular changes are not mediated by altered glucocorticoid feedback and potentially occur downstream for a common modulator of neurotrophic function.

CRH+ cells in human sgACC are a heterogeneous population of GABAergic interneurons, although largely co-expressing VIP. Our data suggest that MDD is associated with reduced markers of inhibitory function in sgACC CRH+ interneurons, and provide further evidence for impaired GABAergic function in the cortex in MDD.
Character Strengths Across Disabilities: An International Exploratory Study and Implications for Positive Psychiatry and Psychology
Authors: Umucu Emre , Lee Beatrice , Genova Helen M. , Chopik William J. , Sung Connie , Yasuoka Mizuka , Niemiec Ryan M.
Published: February 2022

The purpose of this study was to examine the differences in character strengths for people with disabilities by using an international dataset by the VIA Institiute on Character. Specifically, we aimed to explore (a) the top and bottom five character strengths reported by different disability groups and all people with disabilities more broadly, and (b) group differences in each character strength and total character strengths. The investigator contacted the VIA Institute on Character (http://www.viacharacter.org/) for obtaining the dataset for the current study. After data cleaning, our sample size resulted in 11,699 people with disabilities. Among most people with disabilities, the top five character strengths scores were love of learning, honesty, appreciation of beauty and excellence, kindness, and fairness. The bottom five character strengths scores were self-regulation, perseverance, zest, spirituality, and prudence. Knowing that there is heterogeneity in character strengths across groups gives us a better understanding of the areas that people with different disabilities and conditions might thrive and provides clinicians and practitioners with a more nuanced understanding for how to possibly intervene with their clients. Positive psychiatry and psychology implications are discussed.
Volunteer Service and Well-Being of Older People in China
Authors: Yang Hua-lei , Zhang Shuo , Zhang Wen-chao , Shen Zheng , Wang Jia-hao , Cheng Si-meng , Tao Yi-wen , Zhang Si-qing , Yang Li-xingzi , Yao Yi-dan , Xie Lin , Tang Li-li , Wu Yuan-yang , Li Zhi-yun
Published: February 2022

Purpose

The social support theory suggested that involving older people in social activities could increase their level of social participation and interaction, which in turn improved their well-being. However, there has been a heated controversy about whether participating in volunteer services could enhance the well-being of older people, especially for the Chinese sample.

Method

Based on the data from the China Health and Retirement Longitudinal Study (CHARLS) in 2013, this paper used an ordered probit model to examine the impact of older people's participation in volunteer services on their well-being, as well as the differences in the impact across groups and the specific transmission mechanism.

Result

The empirical study found that Chinese older people's participation in volunteerism significantly enhanced their well-being, which remained robust after eliminating the possible effects of self-selection. Further heterogeneity analysis revealed that for female, non-party members and older adults with good economic status, participation in volunteerism has a higher increase in well-being. The mediating effect test indicated that older people's participation in volunteerism affected well-being mainly through enhancing positive emotions.

Conclusion

It is necessary to promote the participation of older people in volunteer services and to clarify the role of government support and advocacy. Proper guidance is given to change the role of older people as care recipients to that of service providers and caregivers, and to continuously enrich the programmes and content of volunteer service to safeguard the well-being of older people.
EMPOWERing Patients With Diabetes Using Profiling and Targeted Feedbacks Delivered Through Smartphone App and Wearable (EMPOWER): Protocol for a Randomized Controlled Trial on Effectiveness and Implementation
Authors: Kwan Yu Heng , Yoon Sungwon , Tan Chuen Seng , Tai Bee Choo , Tan Wee Boon , Phang Jie Kie , Tan Ngiap Chuan , Tan Cynthia Yan Ling , Quah Yan Ling , Koot David , Teo Hock Hai , Low Lian Leng
Published: February 2022

Introduction

Type 2 diabetes mellitus (T2DM) poses huge burden and cost on the healthcare system. Mobile health (mHealth) interventions that incorporate wearables may be able to improve diabetes self-management. The aim of this randomized controlled trial (RCT) is to investigate the clinical and cost-effectiveness of personalized educational and behavioral interventions delivered through an EMPOWER mobile application (app) among patients with T2DM.

Methods

This is a parallel two-arm randomized controlled trial (RCT). Patients with T2DM recruited from primary care will be randomly allocated in a 1:1 ratio to either intervention or control group. The intervention group will receive personalized educational and behavioral interventions through the EMPOWER app in addition to their usual clinical care. The control group will receive the usual clinical care for their T2DM but will not have access to the EMPOWER app. Our primary outcome is patient activation score at 12 months. Secondary outcomes will include HbA1c, physical activity level and diet throughout 12 months; quality of life (QoL), medication adherence, direct healthcare cost and indirect healthcare cost at 6 and 12 months.

Discussion

This RCT will provide valuable insights into the effectiveness and implementation of personalized educational and behavioral interventions delivered through mobile application in T2DM management. Findings from this study can help to achieve sustainable and cost-effective behavioral change in patients with T2DM, and this can be potentially scaled to other chronic diseases such as hypertension and dyslipidemia.
Acute Respiratory Distress Syndrome Caused by Occupational Exposure to Waterproofing Spray: A Case Report and Literature Review
Authors: Fu Meng , Feng Chun-Mei , Cao Le-Jie , Hu Xiao-Wen , Xu Qi-xia , Xia Huai-Ling , Ji Zi-Mei , Hu Na-Na , Xie Wang , Fang Yuan , Xia Da-Qing , Zhang Jun-Qiang
Published: February 2022

Background

Acute respiratory distress syndrome (ARDS) is a serious respiratory disease, caused by severe infection, trauma, shock, inhalation of harmful gases and poisons and presented with acute-onset and high mortality. Timely and accurate identification will be helpful to the treatment and prognosis of ARDS cases. Herein, we report a case of ARDS caused by occupational exposure to waterproofing spray. To our knowledge, inhalation of waterproofing spray is an uncommon cause of ARDS, and what makes our case special is that we ruled out concurrent infections with some pathogens by using metagenomic next-generation sequencing (mNGS) as an auxiliary diagnosis, which presents the most comprehensive etiological examination of similar reports.

Case Presentation

A previously healthy 25 years old delivery man developed hyperpyrexia, chest tightness, cough and expectoration. The symptoms occurred and gradually exacerbated after exposure to a waterproofing spray. The chest computed tomography (CT) finding showed diffuse ground glass and infiltrative shadows in both lungs. The diagnosis of ARDS related to waterproofing spray was established on the basis of comprehensive differential diagnosis and etiological examination. The patient achieved good curative effect after proper systemic glucocorticoid therapy.

Conclusions

The diagnosis and differential diagnosis of acute respiratory failure for outdoor workers, such as delivery drivers or hikers, should be considered whether toxic aerosol exposure exists from daily contacts. The case can educate the public that more attention should be paid to avoid exposure to these chemicals by aerosols/ingestion mode and some preventive strategies should be taken in occupational environment. The treatment effect of glucocorticoids is significant in ARDS patients with general chemical damage caused by inhaling toxic gases and substances.
A Programmable Liquid Crystal Elastomer Metamaterials With Soft Elasticity
Authors: Liang Xudong , Li Dongfeng
Published: February 2022

Liquid crystal elastomers (LCEs) are a rubbery network of polymers with ordered liquid crystal mesogens. The combination of rubber elasticity and the anisotropic liquid crystalline order gives exceptional mechanical properties, like soft elasticity, where near-constant stress accompanies large elastic deformation in the material. However, the soft elasticity in LCEs is often bounded by the intrinsic molecular interactions and structures, limiting the range of programmable mechanical properties and functionalities. Here, we demonstrate that the semi-soft elasticity of LCEs can be integrated into the framework of metamaterials to realize markedly programmabilities. Under uniaxial deformation, each state of the building blocks in metamaterials and the molecular composition of the nematic LCEs is associated with a distinctly different stress-strain relation that is fully elastic. Taking advantage of the tunable bending and stretching deformation enabled by the geometry of the building blocks and the semi-soft elasticity of the nematic LCE in the metamaterials, we can engineer the local stretch and stress at an unmet level of their counterpart composed by elastomers. Numerical simulations and analytical models are developed to relate the metamaterial geometries and the LCE soft elasticity to the mechanical responses. In addition, an elastic region with near-zero stiffness up to a stretch of 1.4 can be designed by connecting the compliant responses due to bending deformation and the soft elasticity in the LCE. We expect that the specialized mechanical tunability enabled by the LCE metamaterials can facilitate the development of advanced forms of mechanical metamaterials and impact the design of robotic systems.
Authoring With Virtual Reality Nuggets—Lessons Learned
Authors: Horst Robin , Naraghi-Taghi-Off Ramtin , Rau Linda , Doerner Ralf
Published: February 2022

Virtual Reality (VR) systems and VR content are complex, and their creation can mainly be conducted by experts in VR and related areas. That makes the use of VR challenging for experts from other domains, such as educators. In this paper, we build up on existing work and investigate the VR nugget concept—small self-contained VR systems that are built from educational design patterns. Particularly, we extend this concept and introduce structured authoring processes based on VR nuggets that show how standalone, combinable, and reusable VR software can serve as a meta-level guide for various VR applications and involve educators as domain experts. We conduct a user study with VR Forge, a VR-nugget-based authoring software tool, to draw conclusions on how pattern-based VR authoring tools should be designed to support domain experts. We compare our results with those of a related study of the VR nugget tool IN Tiles. Based on the comparative results of usability and hedonic quality measures, both anecdotal evidence and statistically significant results support the concept’s potential for VR authoring conducted by practitioners who are not experts in VR. We derive the recommendation that the design of a VR-nugget-based authoring environment will benefit from using both immersive and desktop user interface (UI) technologies and that the authoring workflow will need authors to frequently alternate between the technologies. We state findings and lessons learned from the development and the studies. We contribute insights in developing reusable and use-case-specific VR content and tools and propose authoring processes that focus on the tasks and goals of domain experts as the primary authoring role within educational VR development. Finally, the relevance of VR-nugget-based authoring is supported by anecdotal evidence gathered from over 3 years of investigating and applying it within three educational institutions and a company providing education services.
hsa_circ_0072309 Expression Profiling in Non-small-Cell Lung Carcinoma and Its Implications for Diagnosis and Prognosis
Authors: Zhou Yong , Tong Zhongkai , Zhu Xiaoxiao , Huang Shaoqing , Dong Zhaoxing , Ye Zhenyue
Published: February 2022

Circular RNAs (circRNAs), which fall into the category of endogenous ncRNAs, are linked to disease progression of neoplastic diseases. Whereas, it remains uncharacterized regarding hsa_circ_0072309's function and implications in lung carcinoma (LC). Gene Expression Omnibus (GEO) database was utilized for identifying circRNAs with aberrantly expression in LC. qRT-PCR was responsible for determining hsa_circ_0072309 levels in lung adenocarcinoma (LAC). Also, its involvement in LC cell progression was investigated. Experimentally, hsa_circ_0072309 was identified as one of the most aberrantly down-regulated circRNAs in the GEO database (GSE101684 and GSE112214). qRT-PCR revealed notably down-regulated hsa_circ_0072309 in LAC tissue, which had a close association with adverse 3-year survival, as well as LNM and advanced TNM stage. Based on ROC, the AUC of hsa_circ_0072309 was determined to be 0.887, and its specificity and susceptibility can be improved by combined detection of either CYFRA21-1 or CEA. In a word, hsa_circ_0072309 is lowly expressed in lung cancer patients and the survival rate of lowly expressed patients is significantly lower, a candidate marker with prognostic utility for the disease.
Detection of Herpesviruses in Wild Bird Casualties in Slovenia
Authors: Žlabravec Zoran , Slavec Brigita , Vrezec Al , Kuhar Urška , Zorman Rojs Olga , Golob Zlatko , Račnik Jožko
Published: February 2022

The complete host range of avian herpesviruses in wild birds is unknown, and information about nucleotide sequences is available only in limited cases. The aim of this study was to detect the presence of herpesviruses in wild birds and to gain more information about their phylogenetic relationship. Oropharyngeal and cloacal swabs from 447 wild birds from 15 different orders presented as wildlife casualties were examined for herpesvirus presence with PCR targeting a fragment of the DNA polymerase gene. Herpesviruses were detected in oropharyngeal and/or cloacal swabs in 34 (7.5%) birds belonging to 11 species from six different avian orders: Accipitriformes, Charadriiformes, Columbiformes, Falconiformes, Passeriformes, and Strigiformes. The results of phylogenetic analysis showed that various herpesviruses sequences are present in the wild bird population. Some herpesviruses are host species–specific, whereas in some cases very similar sequences were detected through different avian orders, which confirms findings that herpesviruses are not always restricted to bird species. It seems that herpesvirus transmission could occur by predation from avian prey, and even by superpredation—for example, large owls, such as the Eurasian eagle owl (Bubo bubo) or Ural owl (Strix uralensis), preying on smaller raptors. This can lead to greater infection exposure and is in line with the fact that raptors were the most infected species group. Nevertheless, the individual or simultaneous detection of herpesviruses in oropharyngeal and cloacal swabs shows that both swab samples should be used for herpesvirus detection in wild birds.