bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Toxic and Immunoadjuvant Properties of Nanocomposites
Authors: Korytov K. M. , Dubrovina V. I. , Pyatidesyatnikova A. B. , Vityazeva S. A. , Voitkova V. V. , Prozorova G. F. , Pozdnyakov A. S. , Ivanova A. A. , Balakhonov S. V.
Published: July 2019

Introduction. The current direction in medicine is the creation of immunobiological preparations to increase the effectiveness of specific immunotherapy and immunoprophylaxis, containing immunomodulators in their composition. These natural or synthetic substances can have a regulating effect on the immune system. At present, water-soluble organic-inorganic polymeric materials with nanoparticles of various chemical substances with bactericidal and immunomodulating properties can serve as such promising compounds.The aimof the work is to study the acute toxicity of polymer nanocomposites based on 1-vinil-1,2,4-triazole copolymer with N-vinylpyrrolidone with silver, gold and selenium nanoparticles and their effect on the functional state of immune system cells in vitro.

Materials and methods.The study of acute toxicity was performed on outbred white mice. The activity of superoxide dismutase and glucose-6-phosphate dehydrogenase were studied in guinea pig peritoneal macrophages. The study of spontaneous and nanocomposite-induced production of pro- (interferon gamma and tumor necrosis factor alpha) and anti-inflammatory (interleukin-4) cytokines by blood cells was carried out using clinical material obtained from volunteers using the ELISA method. Results. It has been established that nanocomposites with silver and gold nanoparticles do not cause the death of white mice, their temperature increase and body weight decrease. The average lethal dose for a nanocomposite with selenium nanoparticles was determined as 1 gram per 1 kilogram of animal mass. It was shown that the tested nanocomposites have a stimulating effect on the production of cytokines by human blood cells in vitro. It was established that a nanocomposite with selenium nanoparticles increases the activity of superoxide dismutase and glucose-6-phosphate dehydrogenase. A comparative analysis of their actions with the actions of commercial preparations of biological origin, with immunomodulatory properties.

Conclusion. The data obtained allow us to substantiate the need for further research on the effects of nanocomposites based on 1-vinyl-1,2,4-triazole copolymer with N-vinylpyrrolidone with silver, gold and selenium nanoparticles on the macroorganism in both in vitro and in vivo conditions.
Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia
Authors: Vinogradova E. V. , Mikashinovich Z. I. , Belousova E. S.
Published: July 2019

Background. Statin therapy may be accompanied by a toxic effect on skeletal muscle and liver cells, the molecular mechanisms of which have not yet been fully understood.

Aim.To clarify the peculiarities of changes in the oxygen transport function of erythrocytes and antioxidant mechanisms in erythrocytes and muscles of animals with prolonged administration of statins (simvastatin).

Materials and methods.The study was conducted on outbred male rats, which during the experiment were randomly  assigned to following groups: the control group contained animals on a common ration of the vivarium, the group of comparison – animals with induced hypercholesterolemia, the main group – animals with induced hypercholesterolemia treated with simvastatin. In erythrocytes and muscle tissue of animals, indicators characterizing the state of antioxidant defense and carbohydrate metabolism were determined.

The results.The experiment showed that the administration of simvastatin to animals was characterized by aggravation of hypoxia due to hypercholesterolemia, as indicated by a sharp increase in the concentration of 2,3-BPG and lactate in erythrocytes of animals, as well as a significant decrease in the activity of G6PD. In the muscle tissue of animals, there was a decrease in the  concentration of pyruvic acid and lactate relative to the comparison group, which indicates their intensive participation in metabolic processes.

Conclusion.Based on the data obtained, it can be assumed that the peculiarity of the action of statins in erythrocytes  is the increased oxygen delivery to the tissues, which in muscles was accompanied by a decrease in the level of oxidized products. At the same time, against the background of the use of statins, despite the positive direction of adaptive reactions, signs of oxidative stress remain, which is documented by the imbalance of the SOD-catalase system and a decrease in the activity of glutathione-dependent reactions
Experimental Modeling of General Purulent Peritonitis
Authors: Chepurnykh E. E. , Shurygina I. A. , Fadeeva T. V. , Grigoryev E. G.
Published: July 2019

General purulent peritonitis takes one of the first places in the structure of purulent complications. Despite the im provement of methods of diagnosis and treatment, mortality in postoperative purulent peritonitis remains quite high.

Aim of the study: develop a reproducible model of postoperative general peritonitis to study the pathophysiological mechanisms of its development and the development of pathogenetically substantiated therapy.

Materials and methods. The study was performed on 18 Wistar male rats aged 6 months, weighing 250–300 grams. Animals underwent laparotomy and modeling of postoperative general peritonitis according to the proposed method. Hospital strains of Escherichia coli BRLS 109 and Bacteroides fragilis 109 (strain ISCST1982, registered in Genbank), which we isolated from patients with acute appendicitis, with a total volume of 1.0 ml per animal, were used as infectious agents. Animals were taken out of the experiment under anesthesia with compliance with the rules of euthanasia at 1st, 3rd, 7th days after surgery. For morphological studies, samples of a fragment of the abdominal wall and cecum were taken. Bacteriological studies were performed on the 3rd, 7th day from the beginning of the experiment.

Results. It was established that all animals developed peritonitis with the progression of purulent-destructive changes in the abdominal cavity and the development of adhesions, which was confirmed by the data of the morphological method of research. According to the results of bacteriological studies on the 3rd day, exudate infection was detected in all rats (in 100 % of observations). E. coli BLS were isolated in all cases at concentrations of 103–104 CFU/ml. The strain B. fragilis is inoculated in 3 animals at a concentration of 103 CFU/ml, which made 50 %. By the 7th day, only an aerobic E. coli strain of BLS was detected in peritoneal exudate at concentrations of 103 CFU/ml in the complete absence of growth of B. fragilis.

Conclusion. We have developed a model of postoperative general peritonitis, which allows us to study the dynamics of the development of the inflammatory process in the abdominal cavity and, in terms of its clinical manifestations, is close to a real human disease. The reproducibility of the model is 100 %, which is confirmed by microbiological and morphological data.
Analysis of Long-Term Dynamics of Incidence of Healthcare-Associated Infections in the Irkutsk Region
Authors: Noskova O. A. , Potalitsyna N. E. , Savilov E. D.
Published: July 2019

Introduction.Healthcare-associated infections incidence is one of the most pressing issues in modern healthcare due to their high abundance as well as economic loss they cause.

The aimis to study regional features of the incidence of healthcare-associated infections.

Methods.We conducted a retrospective epidemiological analysis of nosocomial morbidity in hospitals of the Irkutsk region within 2006-2017 years. We used data, presented in the following state reports: “On the state of sanitary and epidemiological welfare of the population in the Russian Federation”, “On the state of sanitary and epidemiological welfare of the population in the Irkutsk region”.

Results and discussion.According to the results of the conducted analysis, it was shown that the average long-term prevalence of healthcare-associated infections in the Irkutsk region was 41.94 ± 2.040/00000 (Russian Federation – 17.49) with a tendency to stabilization in recent years. The therapeutic and prophylactic organizations of the surgical profile have the highest epidemiological significance (over 51 %). At the same time, the share of postoperative complications during the study period decreased by 1.5 times. We have noted a rising trend line with a positive rate of increase in the incidence of nosocomial pneumonia, which in the last two years has taken a leading position in the structure of healthcare-associated infections. The incidence of infections in newborns in the Irkutsk region ranks the third, with a specific weight of 11.54 %. Moreover, if before 2013 purulent-septic diseases of the newborns were the predominant nosological form, in recent years pneumonia has firmly taken over the leadership. During the study period we revealed an increase in the incidence of postpartum endometritis in puerperas. It has been shown that the registration of sepsis, urinary tract infections in the region is low.
Parametric Features of Regional Cerebral Blood Flow in Venous Ischemic Stroke
Authors: Semenov S. E.
Published: July 2019

The lecture is devoted to the peculiarities of changes in tissue and cell perfusion of the brain with a rare pathology – venous ischemic stroke. Venous stroke, being a “relatively unknown cerebrovascular disease”, occurs up to 5 % of all cases of stroke. The terms “venous ischemia” and “venous stroke” have long been used in the literature and the definition of the venous nature of stroke should lead to a change in therapeutic tactics. Neuroimaging should ensure the verification of stroke and cerebral venous sinus thrombosis, which are the main cause of such a stroke. A certain “alertness” to the venous nature of the stroke with the expansion of the volume of radiologic methods of investigation and the performance of angiographic and perfusion CT and MR techniques, diffusion MRI allowed to increase the number of diagnosed and verified venous strokes from 0.4 % of the total number of stroke patients to 2.4 %. A distinctive feature of venous ischemic stroke from the arterial is moderate hyperemia in the central part in cases where necrosis does not develop and perifocal hyperperfusion in the development of necrosis. Moderate plethora, defined by perfusion parameters (up to 30 % CBF, CBV, MTT) of CT, MRI and SPECT techniques, and not oligemia is the primary damaging factor of the pathogenesis of venous stroke in contrast to the arterial and hyperemia patterns should be the reference points in emergency diagnosis venous stroke along with tomoangiographic symptoms of cerebral venous sinustrombosis.
Genetic Aspects of Pathogenesis of Congenital Spastic Cerebral Paralysis
Authors: Prityko A. G. , Chebanenko N. V. , Sokolov P. L. , Zykov V. P. , Klimchuk O. V. , Kanivets I. V.
Published: July 2019

Congenital spastic cerebral palsy (СР) is a large group of non-progressive disorders of the nervous system. The basis of the pathogenesis of these conditions is considered the impact of many factors. The clinical diversity of the disease and the syndromic principle of classification determine the existing uncertainties in the diagnosis of these diseases. The multifactorial nature of the underlying brain lesions is obvious and beyond doubt. The volume of information accumulated to date does not allow one to exclude the role and significance of the direct effect of acute asphyxiation in childbirth on a fetus normally formed during pregnancy, the role of infectious brain lesions, and disorders of neuronal migration. It is impossible to ignore the dependence of the clinical picture of the disease on what stage of ontogenesis the impact of the damaging agent occurs. As one of the pathogenetic factors, the genetic determinism of the phenotype of the clinical picture of a disease is fairly considered. This review focuses on the genetic aspects of the pathogenesis of this pathology. The information on monogenic mechanisms of inheritance is analyzed in detail. Such genetically determined mechanisms of pathogenesis as the inheritance of prerequisites for brain trauma in the perinatal period are considered separately. The new clinically significant variants of chromosomal mutations found in patients with CР are reviewed in detail,  the evidence of the influence of genetic factors on the development of cerebral palsy in the absence of a pronounced monogenic cause of the disease, obtained through twin studies, is reviewed.  Lit search of polymorphisms markers of predisposition to the development of cerebral palsy genes of the folate cycle, genes of glutamate receptors, the gene of apolipoprotein and of the gene for the transcription factor of oligodendrocytes (OLIG2) in Detail the role of epigenetic effects on the activity of genes coding for mitochondrial proteins.
Pharmacogenetic Warfarin Dosing Algorithm in the Russian Population
Authors: Bairova T. A. , Sambyalova A. Yu. , Rychkova L. V. , Novikova E. A. , Belyalov F. I. , Sargaeva D. S. , Shchedreeva E. A. , Ignatyeva T. G. , Ershova O. A. , Pustozerov V. G. , Kovaleva O. A. , Rasputina I. V. , Noskova I. A. , Batogova T. V. , Kuznetsova O. V. , Bogoslova O. Yu. , Kolesnikov S. I.
Published: July 2019

Background. To date, there are many pharmacogenetic algorithms for selecting the dose of warfarin. However, there is very little information about the predictive accuracy of the algorithms. We decided to evaluate the predictive accuracy of the Gage algorithm, using a calculator, located on the web site (http://www.warfarindosing.org) in two ethnic groups (Caucasians and Asians), living in Russia.

Aim. To compare the actual warfarin dose (AWD) to the calculated warfarin dose (CWD), using the algorithm in two ethnic groups taking warfarin.

Materials and methods. We included 114 patients (66 Caucasians and 48 Asians): the mean age was

60.91 ± 12.34 years; 61 (53.51 %) men, and 53 (46.49 %) women. The comparative characteristics of the algorithm were tested using the mean absolute error (MAE) between AWD and CWD, and percentage of patients, whose CWD fell within 20 % of AWD (percentage within 20 %). Genotyping for CYP2C9*2, CYP2C9*3, CYP4F*2 and VKORC1 was performed by real-time polymerase chain reaction (RT-PCR) method using Pharmacogenetics Warfarin reagent kits (DNA technology, Russia).

Results. The Gage algorithm produced the predictive accuracy with MAE = 1.02 ± 0.16 mg/day and percentage within 20 % for Asian patients was 39.6 %. We obtained MAE = 1.33 ± 0.16 mg/day and percentage within 20 % for Caucasian patients was 40.9 %. In two ethnic groups (Caucasians and Asians) of the Russian population, overall performance of warfarin pharmacogenetic dosing by the Gage algorithm was similar.

Conclusions. Despite the performance limitation of the current warfarin pharmacogenetic dosing Gage algorithm, constant international normalized ratio monitoring is important.
Relative Risk Assessment of Intrauterine Infection of the Fetus During Cytomegalovirus Infection in Early Pregnancy
Authors: Petrova K. K.
Published: July 2019

Background. Intrauterine fetal infection (IUI), the common cause of which is the cytomegalovirus (CMV), occupies one of the first places in the structure of perinatal morbidity and mortality. There are no data on the relative risk assessment of IUI at the exacerbation of CMV infection and its delitescent course in first trimester of pregnancy in the literature.

Aim: to calculate the relative risks of fetal IUI in pregnant women with exacerbation of CMV infection in the first trimester of pregnancy.

Methods. A retrospective review of the labor and delivery medical records and prenatal records of 104 CMV-seropositive women was carried out. Fifty of these women had an exacerbation of CMV infection in the first trimester of pregnancy – main group and 54 of them were with delitescent course of the disease (comparison group).

Results. A comparative analysis of ultrasound and morphological markers of IUI with risk assessment depending on the course of CMV infection in the first trimester of pregnancy has been carried out. A high risk of placental structure abnormalities, as well as amniotic fluid and fetal membranes, fetal and placental blood flow pathology, onset of  choroid plexus cyst and fetal growth restriction was found, with a statistically significant difference in the group of pregnant women with exacerbation of CMV infection in the first trimester of pregnancy.

Conclusion. The findings suggest that the exacerbation of CMV infection in early pregnancy is a risk factor for IUI.
HERBERT MARCUSE E A TEORIA CRÍTICA: PARA ALÉM DA PERSPECTIVA NORMATIVA DA ESCOLA DE FRANKFURT
Authors: Carneiro Silvio Ricardo Gomes
Published: July 2019

Nosso ensaio procura compreender o sentido atual da Teoria Crítica de Herbert Marcuse. De início, fazemos a contraposição de Marcuse à versão mais contemporânea da Teoria Crítica, representada pela perspectiva normativa de Jürgen Habermas e Axel Honneth. Notamos, em seguida, a insuficiência deste modelo crítico diante dos desafios contemporâneos, conforme a crítica de John Abromeit e Amy Allen. Ambos apresentam os limites da segunda geração para compreender o avanço do pensamento conservador. Recuperamos aqui as reflexões de Marcuse sobre os limites da democracia burguesa nos anos 1970. Este será o mote para pensarmos uma perspectiva de Teoria Crítica diversa da normatividade. A experiência crítica de Marcuse é marcada pelo contorno dos acontecimentos e dos corpos, o conteúdo material das questões morais – elementos centrais para o embate contra a cultura do medo que alimenta o autoritarismo nas vias democráticas.
EROS ÀS AVESSAS: PANSEXUALISMO E DESSUBLIMAÇÃO REPRESSIVA
Authors: Silva Rafael Cordeiro
Published: July 2019

O artigo pretende explanar o conceito de Eros como uma categoria social no pensamento de Herbert Marcuse. Nesse sentido, o erotismo tem um significado político para o autor, pois indica a possibilidade de libertação das formas sociais repressivas. Na primeira seção, faço um breve relato da relação de Marcuse com a psicanálise, anterior a seu contato mais intenso com Freud. Na segunda seção, mostro o caráter essencialmente político e social de Eros, através da reconstrução da teoria marcusiana da mudança social. Em seus escritos, Marcuse também menciona as formas pervertidas de manifestação de Eros, representadas pelo pansexualismo e pelo que ele denomina dessublimação repressiva. Nesse contexto, pretendo discutir o que essas 'perversões' significam. O pansexualismo é analisado em Eros e civilização e em outros escritos da década de 1950 e 1960. Pretendo discutir também se o conceito de pansexualismo se encaixaria ou não na perspectiva libertária que o filósofo quis significar com a politização de Eros. À dessublimação repressiva o filósofo dedica o terceiro capítulo de O homem unidimensional. Da mesma forma, o significado da dessublimação repressiva também será discutido na terceira seção do artigo. Na conclusão, mostro que Marcuse entende que o pansexualismo e a liberação sexual sem tabus não podem ser vistos como libertação política, são apenas formas pernósticas de manifestação de Eros.
A CARTA DE FEUERBACH A HEGEL
Authors: Serrão Adriana Veríssimo
Published: July 2019

As três cartas que nos finais de 1828 acompanham o envio da dissertação De ratione, una, universali, infinita apresentada por Ludwig Feuerbach à Universidade de Erlangen, embora de desigual relevo quanto ao conteúdo filosófico, formam no seu conjunto um documento de especial interesse para a compreensão da biografia intelectual de Feuerbach [...]
A RELAÇÃO TRABALHO-EDUCAÇÃO NO PENSAMENTO DE MARX: UM ESTUDO DOS MANUSCRITOS ECONÔMICO-FILOSÓFICOS (1844)
Authors: Almeida José Salvador de , Chagas Eduardo Ferreira
Published: July 2019

Este artigo objetiva demonstrar e explicitar a relação entre trabalho-educação no pensamento de Marx, a partir de um estudo dos Manuscritos econômico-filosóficos (1844), especificamente, do manuscrito intitulado, a saber: Trabalho Estranhado e Propriedade Privada. Neste trabalho, apresentamos, inicialmente, o debate de Marx com a economia nacional e, na sequência, a teoria sobre o estranhamento na essência do trabalho [trabalho estranhado] e, por fim, a relação trabalho-educação para este pensador materialista. Durante o desenvolvimento da referida pesquisa, adotamos como procedimento metodológico o método dialético-crítico-reflexivo, pois tal método, no nosso entendimento, permite uma melhor compreensão dos escritos de Marx. Ao final da pesquisa, evidenciamos que existe uma relação íntima entre trabalho-educação no pensamento de Marx, pois a educação deve proporcionar ao homem (trabalhador) uma relação imediata e de reconhecimento entre o trabalho (atividade vital consciente e livre) e a produção, isto é, entre o trabalhador e os objetos da produção. No capitalismo, tal relação, portanto, se apresenta como uma relação hostil e estranha, pois o trabalhador não se reconhece no produto do seu próprio trabalho, uma vez que este trabalho se apresenta como trabalho estranhado.
Strategi Literasi dalam Pembelajaran Matematika pada Era Industri 4.0
Authors: Baiduri Baiduri
Published: July 2019

Setiap siswa atau manusia ingin sukses, baik secara akademik maupun dalam kehidupan kesehariannya. Kehadiran industri 4.0 membawah perubahan yang sangat cepat, tidak hanya dalam dunia manufaktur dan produksi tetapi juga dalam skill yang dibutuhkan di dunia kerja. Kecapakan yang sangat penting dan mendasar untuk ini adalah kecakapan bahasa dan kecakapan matematika.  Kecakapan matematika meliputi kosakata dan notasi, ruang dan bentuk, numerasi, dan kuantitatif. Makna yang tersirat dalam kecakapan (literasi) matematika adalah kemampuan untuk mengajukan, merumuskan, dan memecahkan masalah intra dan ekstra matematika dengan bahasa yang dapat dimengerti oleh orang lain umumnya dan matematikawan pada khususnya. Berbagai strategi literasi dibahas secara teoritis dan implementasinya dalam pembelajaran matematika supaya dapat mahir secara matematis agar dapat mengambil keuntungan hadirnya era industri 4.0 atau era setelahnya.
Analisa Perawatan Mesin Pulper Menggunakan Metode Overall Equipment Effectiveness (OEE)
Authors: Ahlaq Ade Mukhlis Shoutul , Cahyadi Dadi , Handika Firdanis Setyaning
Published: July 2019

This study aims to determine the effectiveness of Pulper machines. The research was conducted using the Overall Equipment Effectiveness method. The research conducted at a company engaged in the Pulp & Paper field. Data collected by interviews and conducting direct observations in the area during February 2017. Based on the research, it can conclude that the Pulley OEE value was obtained by 77.31% with the main factor causing damage was Broken Ragger by 46%. The proposed improvements that can be given to minimize the incidence of broken ragger are training of ragger machine operators regularly, planning maintenance of scheduled ragger machines as well as providing tools to make it easier for operators to repair damaged machines
Usulan Perbaikan Proses Cross Drainage untuk Mempercepat Waktu Proyek Pembangunan Jalan Raya
Authors: Shofa Mohamad Jihan , Listiyana Lanis , Cahyadi Dadi
Published: July 2019

The success of the project can be judged by the timeliness of the planned target. The problem in the highway project is in the difference between cross drainage age implementation and the age of the project plan that has been set, so that, the project becomes not timely. This research aims to evaluate the critical path of cross drainage project, and what improvements are appropriate in the framework of project acceleration. The Critical Path Method (CPM) method is used to determine the critical path of the cross drainage project activity, from which critical path will be analyzed by using the Fishbone Diagram. Furthermore, borda technique is used to determine the appropriate improvement.
Analisis Pengendalian Persediaan Sistem Manajemen Persediaan Bahan Baku Kemasan
Authors: Suryani Suryani , Can Dedi
Published: July 2019

Inventory is one of the things that must be considered by the company. One way is to manage inventory management. The problem that occurs in the research location is the lack and excess stock for packaging raw materials. This lack of capital is due to the absence of calculations for the number of safety stock and reorder points, the cause of excess inventory is the excess in the absence of groupings of packaging raw materials to find out which products are more critical according to demand. Analysis of system improvements focuses on packaging raw materials. Based on the results of data processing obtained from 304 existing packaging raw materials, there are 15 packaging raw materials in class A. Processing is focused on class A only. Forecast calculations using SPSS software. And processing is continued by using the size-reorder point systems lot method with quantity results, reorder margin and safety stock that varies 15 raw materials according to the calculations performed.
Analisis Cacat Produk Green Tyre dengan Pendekatan Seven Tools
Authors: Hardono Joko , Pratama Hendra , Friyatna Andi
Published: July 2019

Quality is one aspect that needs to be maintained in increasing consumer confidence and minimizing production costs. A motorcycle tire manufacturing company has a production defect of 5028 during February 2018. This study aims to reduce the number of defective products in the green tire cooking process in the curing area. The methods used in this study are seven tools, especially Pareto diagrams, and fishbone diagrams and analyzed the cause is 5W1H. Of the six types of green tire defects, under cure is the most dominant factor (40%) that causes disability. The improvement in Pneumatic Problems which the problem of under cure is human factors, machinery, and the method of being able to reduce defects by 48% from 891 pieces in February to 463 pieces in May. The decrease in defects in pneumatic problems affects the reduction in the number of defects in green tire products from 5206 pieces in February to 4699 pieces in May.
Long-term results of complex therapy in patients with nonreconstructible chronic lower limb ischemia
Authors: N. Yu. Litvinova  , D. E. Dubenko  , O. I. Kefeli-Yanovska
Published: July 2019

The aim — to improve the results of surgical treatment of patients with chronic critical lower limb ischemia by developing methods of autologous transplantation of multipotent stem mesenchymal stromal cells, administration of endothelial cells growth factors and therapeutic and diagnostic measures to preserve the lower limb or reduce the level of its amputation, reduce ischemia and the frequency of disability of such patients, improve their quality of life.Materials and methods. The study included 110 patients with a clinical picture of pain at rest, ischemic edema, and trophic changes (IIIA, IIIB, and IV stage of lower limb ischemia according to the classification of the European Association of Angiologists and Vascular Surgeons) caused by nonreconstructible occlusive and obliterating diseases of lower limb arteries. The patients were divided into three groups according to the method of treatment: in the 1st group (n = 48), revascularization osteotrepanation was performed as an operation of indirect revascularization, in the 2nd group (n = 21) a drug of endothelial cells growth factor was administered to stimulate their own angiogenesis, in the 3rd group (n = 41) subcutaneous fat was collected, autologous mesenchymal cells were cultivated and transplanted according to the developed technique. The control group of patients (n = 50) was selected retrospectively according to the case histories in accordance with the criteria of involvement and the results of treatment which could be followed up in a 3‑year observation period.Results and discussion. The safety of the lower limb in the 3rd group was statistically more significant than in the 1st and 2nd groups and remained at the level of 82 % after three years of observation. The smallest number of large amputations was in the 3rd group (2.3 % — above knee‑joint and 7.3 % — below, knee‑joint whereas in the control group the number was 18 % and 24 %, respectively).Conclusions. The level of high amputations directly affects the life expectancy of patients. Only treatment in the 3rd group reduced the risk of large amputation compared with the control group (odds ratio 2.752 (95 % confidence interval — 1.12 — 6.733)). Only treatment in the 3rd group reduced the risk of amputation compared with other types of treatment (odds ratio 0.358 (95 % confidence interval 1.111 — 1.158).
Determination of indications for and long-term results of femoral-popliteal (distal) alloshunting using polytetrafluoroethylene implants in patients with obliterating atherosclerosis on the background of critical ischemia
Authors: A. M. Bytsai
Published: July 2019

The aim —  improvement of the results of reconstructive operations in patients with obliterating atherosclerosis of the vessels of lower extremities with multiple occlusal‑stenotic lesions on the background of critical ischemia.Materials and methods. The distant results were analyzed of femoropopliteal (distal) alloshunting with the use of polytetrafluoroethylene (PTFE) implants in 121 patients with two‑level occlusive‑stenotic lesions of the lower extremities. The group of patients with «satisfactory» state of distal blood flow, according to Rutherford, was divided into 2 subgroups, depending on the level of distal retrograde blood flow (according to the indications of intraoperative debitometry).Results and discussion. A comparative retrospective analysis of the results of the reconstructions showed a direct dependence of early and distant results of operations on the level of lesion of shank and foot distal blood flow. A differentiated approach in patients with «satisfactory» distal blood flow, according to Rutherford, allowed optimizing the surgical tactics and determining the indications for surgical intervention due to the use of intraoperative debitometry.Conclusions. Determination of quantitative indices of retrograde blood circulation with intraoperative debitometry allows objectivizing the status of the distal bed of the lower extremities, improving the results of the femoro‑popliteal (distal) alloshunting in the remote observation period (up to 4 years). When diagnosing the retrograde blood flow to the popliteal artery less than 60 ml/min, the patient has a high risk of thrombosis of the femoro‑popliteal (distal) alloshunt in the first year of observation. The use of the «Gincor Forte» drug can effectively reduce the manifestations of secondary lympho‑venous insufficiency on the background of reperfusion syndrome in 85 % of patients after the femoro‑popliteal (distal) alloshunt.
Changes of indices of diurnal blood pressure monitoring under the influence of treatment in patients with essential hypertension complicated with hemorrhagic stroke after early recovery period
Authors: O. V. Tkachyshyn
Published: July 2019

The aim —  to compare the indices of diurnal blood pressure monitoring (DBPM) in patients with essential hypertension (EH) іn ≥ 6 months after hemorrhagic stroke (HS) before and after treatment with combination of amlodipine, valsartan, hydroclorothiazide (if necessary) and magnesium oxide monohydrate.Materials and methods. The main group included 33 patients, the comparison group comprised 13 persons. In the first group the office blood pressure (BP) was і 140/90 mm Hg, in the second one it was lower. The groups were matched by main indicators. DBPM was performed twice (before and after treatment) for the main group of patients, and once for the comparison group patients.Results and discussion. In the main group, before and after treatment the mean systolic blood pressure (SBP) was 110.1 ± 16.0 mm Hg and 102.3 ± 12.6 mm Hg, respectively, at daytime, 102.6 ± 17.3 and 83.9 ± 8.1 mm Hg at night, 109.7 ± 15.7 and 96.3 ± 11.9 mm Hg (p < 0.05) per day. The maximum SBP at daytime in the main group was higher before the treatment (169.3 ± 18.4 mm Hg, p < 0.05). The value of the standard deviation of SBP and pulse BP decreased after treatment (p < 0.05). The value of the mean real variability of SBP in the main group was 11.27 ± 2.73 mm Hg before treatment and 9.74 ± 1.84 mm Hg (p < 0.05) after it. Diurnal index of SBD in the main group was 4.95 ± 9.67 % before treatment and 11.44 ± 5.43 % after it.Conclusions. The treatment of patients with EH, who had suffered HS ≥ 6 months before and had office BP ≥ 140/90  mm Hg, with combination of amlodipine (daily dose 5 — 10 mg), valsartan (daily dose 80 — 160 mg), hydroclorothiazide (12.5 mg if necessary) on the basis of chronotherapy approach and magnesium oxide monohydrate (456 mg daily during 1 month period) permits achieving the control of BP according to DBPM data in 73 % of patients. This treatment also permits statistically significant decreasing of short‑term BP variability, in particular, the standard deviation in all time intervals and the average real variability of SBD.
Risk factors for death at long-term follow-up after acute coronary syndrome in patients with atrial fibrillation
Authors: V. Y. Tseluyko  , F. Ben Salem  , O. E. Matuzok
Published: July 2019

The aim —  to evaluate the predictive significance of clinical, instrumental and laboratory parameters regarding the mortality of patients with acute coronary syndrome (ACS) and atrial fibrillation (AF) at long‑term follow‑up (over 2 years).Materials and methods. We examined 125 patients with ACS. In 26 (18; 40) months, the information regarding the vital status was collected. The data was available for 67 patients. 22 (32.8 %) of them developed new‑onset AF during the acute disease phase; 11 (16.4 %) had AF before ACS; 34 (50.8 %) had no signs of AF in their medical history and during hospitalization. Blood samples for determination of N‑terminal fragment of brain natriuretic peptide (NT‑proBNP) were taken during the first 24 hours of the disease by enzyme immunoassay.Results and discussion. 14 patients died during the follow‑up period, the mortality rate was 20.9 %. Mortality in patients who developed new‑onset AF on the background of ACS was higher than mortality in patients without AF (36.4 % vs 11.8 %, respectively; р = 0.033); odds ratio was 4.29 (95 % confidence interval — 1.08 — 14.62). Mortality in men was 12.5 %, in women — 33.3 % (р = 0.040). Percentage of smokers was statistically significantly higher in patients who survived (р = 0.007). Prevalence of anemia was 11.3 % in patients who survived and 57.1 % in patients who died (р = 0.0001). Patients who died had higher levels of NT‑proBNP (р = 0.016), glycemia (р = 0.008) and C‑reactive protein (р = 0.005) at admission. ROC‑analysis showed that the risk of death was associated with red blood cell count ≤ 4.09 · 1012/l (р = 0.0004), hemoglobin level ≤ 117 g/l (р = 0.0008), glycemia > 6.6 mmol/l (р = 0.002), C‑reactive protein > 24 mg/l (р = 0.0008), NT‑proBNP > 1788 pg/ml (р < 0.0001).Conclusions. Mortality of patients after ACS at 26 (18; 40) month follow‑up was 20.9 %. Mortality in patients who developed new‑onset AF on the background of ACS was 36.4 %, which was statistically significantly higher than mortality in patients without AF. Female patients, patients with anemia and non‑smokers were more likely to die. ROC‑analysis established laboratory test indices associated with the death risk.
Role of single nucleotide Т786C polymorphism of endothelial NO-synthase gene after myocardial infarction with ST-segment elevation
Authors: O. V. Petyunina  , M. P. Kopytsya  , A. E. Berezin  , D. P. Babichev
Published: July 2019

The aim — of research was to investigate possible associations between single nucleotide T786C polymorphism of endothelial NO‑synthase (eNOS) gene and clinical events in acute period of myocardial infarction with ST segment elevation (STEMI) and after 6 months of follow‑up.Materials and methods. 177 patients with acute STEMI (139 (78.5 %) males and 38 (21.5 %) females) at average age 61.73 ± 9.44 years that were included to the study between January 2016 and July 2018 were examined. Primary percutaneous coronary intervention using bare‑metal stent (BMS) was performed in 133 patients. In 44 patients system thrombolyses were previously performed. All patients were able to achieve recovery of blood flow at TIMI III level. To determine the T786C polymorphism of the eNOS gene, polymerase chain reaction was used with an electrophoretic scheme for detecting the result in real time. The combined endpoint (repeated hospitalization, de novo heart failure, angina pectoris, cardiovascular death, which occurred 6 months after discharge from the hospital) was analyzed.Results and discussion. The combined endpoint was observed in 24 carriers of 786TT genotype of eNOS gene, in 23 individuals with the 786TC genotype and in 25 patients with 786CC genotype. Kaplan‑Meier curves showed that patients with STEMI carriers of 786CC genotype had a higher incidence of a combined endpoint than individuals with the 786TC and 786TT genotypes after 6 months of follow‑up. Multivariate logistic regression analysis revealed that the 786CC polymorphism of eNOS gene is an independent predictor of adverse clinical events 6 months after STEMI.Conclusions. Along with traditional risk factors (SYNTAX score, TIMI score, abdominal obesity) 786СС polymorphism of eNOS gene was found as an independent predictor for adverse cardiovascular events in 6‑month observation period after successful primary percutaneous coronary intervention in STEMI patients.
Clinical and diagnostic characteristics of peripheral vasculopathy biomarkers in systemic scleroderma
Authors: Ye. D. Yehudina  , I. Yu. Golovach
Published: July 2019

Vascular lesion is a hallmark of systemic scleroderma (SS). Vasculopathy occurs in every patient with SS. It can be the earliest clinical manifestation or cause the main life‑threatening complications of the disease, and thus determine morbidity and mortality. In SS, progressive vascular damage is characterized by constant activation/damage and apoptosis of endothelial cells, intimal thickening and vasoconstriction, leading to the lumen obliteration. Vascular remodeling leads to a violation of their tone and a decrease in capillary blood flow, followed by tissue ischemia and chronic hypoxia. These phenomena are often accompanied by altered levels of vascular factors. Among the most significant biomarkers of vasculopathy in SS with the greatest evidence base we define anti‑AT1R and anti‑ETAR, soluble intercellular adhesion molecules (sICAM‑1), soluble molecules of adhesion of thrombocyte endothelial cells, placental growth factor (PlGF), pro‑angiogenic angiopoietin‑like protein‑3 (ANGPTL‑3), apelin, chemokines (CXCL5), galectin‑3, E‑selectin, tissue kallikrein, interleukins (IL)‑13 and ‑33, vascular endothelial growth factor (VEGF165b), matrix metalloproteinases‑12, endothelin‑1, nodal adhesion molecules which are associated with the development of either digital ulcers or changes on videocapillaroscopy typical for SS. This shows their active role in the pathogenesis of SS, especially during the disease manifestation. Data is presented on the most significant vascular biomarkers and the main connections between vascular biomarkers and capillaroscopic parameters and/or the presence of digital ulcers in SS. Vascular biomarkers can become prognostic factors of vascular damage at SS, which allows early treatment of vascular complications.
Moral Judgements on the Actions of Self-driving Cars and Human Drivers in Dilemma Situations from Different Perspectives
Authors: Kallioinen Noa , Pershina Maria , Zeiser Jannik , Nezami. Farbod Nosrat , Stephan Achim , Pipa Gordon , König Peter
Published: July 2019

Self-driving cars have the potential to greatly improve public safety. However, their introduction onto public roads must overcome both ethical and technical challenges. To further understand the ethical issues of introducing self-driving cars, we conducted two moral judgement studies investigating potential differences in the moral norms applied to human drivers and self-driving cars. In the experiments, participants made judgements on a series of dilemma situations involving human drivers or self-driving cars. We also manipulated which perspective situations were presented from in order to ascertain the effect of perspective on moral judgements. Largely, human drivers and self-driving cars were judged similarly. However, there was a stronger tendency to prefer self-driving cars to act in ways to minimise harm, compared to human drivers. Furthermore, there was an indication that perspective influences judgements, such that people prefer to save themselves at the expense of others. The results generally agree with previous research, again contradicting existing ethical guidelines for self-driving car decision making and highlighting the difficulties with adapting public opinion to decision making algorithms.
Many Paths: "As-you-go"-publication system [Grant proposal]
Authors: Götz Martin , Hartgerink Chris Hubertus Joseph , Maassen Esther , van Dijk Hans , van Zelst Marino
Published: July 2019

To improve the way in which research is currently conducted and communicated, Hartgerink and van Zelst (2018) have recently suggested a new research communication infrastructure. In their vision, research output is communicated continuously “as-you-go” as opposed to the current system where research is only communicated after the entire cycle has been completed (i.e., “after-the-fact”). This “as-you-go” system offers a host of advantages, including more transparency and a more rapid dissemination of research output. To examine the viability of their system, I aim to build a functioning implementation of their proposed infrastructure to investigate the research question “Does power corrupt?”Specifically, in this application I propose the Many Paths model, which starts with one research question and allows an emergent process to occur thereafter. Given that results are often path dependent and many paths can be taken in a research process, it is worthwhile to study which what paths a research project initiated, pruned, and merged. The Many Paths model offers insight into how researchers from different disciplines approach and study the same research question in a different way, and how that may relate to different conclusions being reached. As such, the project offers insight into the value of the “as-you-go” form of research communication. Furthermore, by inviting researchers from various disciplines to collaboratively address the question “Does power corrupt?” the Many Paths project offers a collaborative and integrated approach to that age-old question. The funding will be used primarily to set up the communication infrastructure that will allow the emergent collaborative project in the form of Many Paths to happen. Here, researchers communicate each step of the research process directly after it occurred, thereby linking each step to a previous one. This structure allows for the paths of the research process to be investigated. Moreover, the “as-you-go”-communication infrastructure allows collaborators to prune their own research progress into different areas, as they observe and get inspired by the other collaborators. The remainder of the funding will be used for a data scientist to analyze the paths via which researchers communicate on the Many Paths project, to support data collection (if needed) and for organizing meetings on the project.
Administrasi Pendidik dan Tenaga Kepenidikan
Authors: dewi septi putri , Afriansyah Hade
Published: July 2019

Administration of educators and education personnel is the overall process of the activities of educators to achieve educational goals effectively and efficiently. In this article the author uses the literature study method, by collecting material sourced from review, journals and others related to the administrative process of educators and education personnel. The purpose of this article is to fulfill structured assignments in the Administration and Supervision of Education courses. And it is knowledge especially for compilers and generally for readers, regarding the Administration of Educators and Education Personnel.
Prosiding Seminar Nasinonal STKIP Muhammadiyah Bogor 2017 Pemberdayaan Individu Melalui Konsep Link And Match Dalam Perspektif Pendidikan Islam
Authors: Arsyad Arsyad , Sulfemi Wahyu Bagja
Published: July 2019

Manusia dengan segala potensinya membutuhkan berbagai bentuk pendekatan untuk menemukan nilai fitrahnya. Bimbingan jasmani dan rohani berdasarkan hukum-hukum agama Islam menuju kepada terbentuknya kepribadian utama menurut ukuran-ukuran Islam merupakan substansi dari roses pendidikan Islam. Link and Match sebagai suatu konsep yang menawarkan integrasi antara luaran pendidikan dengan dunia kerja merupakan konsepsi yang yang relevan dengan eksistensi manusia sebagai makhluk sosial. Bertolak dari konsep manusia yang bersifat integral-holistik, maka sistem pendidikan dalam Islam lebih berorientasi pada persoalan dunia dan ukhrawi sekaligus, sehingga orientasi pendidikan ditekankan pada pengembangan seluruh potensi yang dimiliki oleh maunsia untuk menjalankan amanah dan tanggung jawabnya sebagai hamba khalifah di muka bumi ini. Dengan demikian, integrasi antara konsep link and Match dengan proses pendidikan pada aspek jasmani, akal dan ruhani dalam diri setiap individu dapat mengejawantahkan peran manusia yang sebenarnya sebagai wakil Allah di muka bumi
Teori pengambilan keputusan
Authors: mutiararahmadila  , Afriansyah Hade
Published: July 2019

decisions are the result of resolving the problems they face firmly. Questions about questions about questions what to do and planning about nothing. Can also answer that decision is the result of a thought process that represents elections that can be used to solve the problem at hant.The decison itself is a vital element of activity. The soul of one’s leadeship can be seen from the ability to overcome problems and make the right decisions. The right decision is a decision that is weighty and acceptable to subordinates. This is udually a balance between the discpline that must be upheld and the human attitude towards subordinates. This decision is also called a decision based on human relations.
PEMETAAN KOMPETENSI SISWA SMA PADA MATA PELAJARAN SOSIOLOGI DI KOTA PARIAMAN DAN KABUPATEN PADANG PARIAMAN PROVINSI SUMATERA BARAT
Authors: Sylvia Ike
Published: July 2019

Penelitian ini bertujuan untuk: (1) Mendapatkan gambaran tentang kompetensi siswa pada mata pelajaran Sosiologi yang diujikan pada Ujian Nasional; (2) Mengidentifikasi faktor-faktor penyebab siswa belum mengua sai standar kompetensi/kompetensi dasar yang diujikan pada Ujian Nasional; dan (3) merumuskan alternatif pemecahan masalah yang valid dan siap diimplementasikan secara konkrit di kota Pariaman dan kabupaten Padang Pariaman. Sampel penelitian ini diambil berdasarkan wilayah, yaitu wilayah kota Pariaman diambil 3 sekolah yaitu: SMA Negeri I, SMA Negeri 2, dan SMA Manunggal Bakti. Wilayah kabupaten Padang Pariaman yaitu: SMA Negeri 1 2 x 11 Enam Lingkung, SMA Negeri 2 Sungai. Limau, SMA Negeri 1 Batang Anai, dan SMA Negeri Tapakis. Objek penelitian ini adalah mata pelajaran Sosiologi. Data primer diperoleh melalui wawancara, observasi dan kuesioner sedangkan data sekunder diperoleh melalui dokumentasi. Hasil penelitian menunjukkan ada beberapa aspek dari delapan Standar Nasional Pendidikan yang belum berjalan sebagaimana mestinya, sehingga perlu adanya beberapa pembenahan.
Administrasi Pendidikan
Authors: yaum subbaful , Afriansyah Hade
Published: July 2019

This article explains the administration and infrastructure of education in Indonesia, which consists of providing educational facilities, which are conducted centrally in the Administration section, the implementation of educational facilities has not been done well as seen from the availability of appropriate education, provision of facilities education, direct supervision. In this article describes the components of educational facilities and infrastructure such as the stages, objectives, roles and functions of a teacher for the teacher and as an administrative institution.