bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY TO EVALUATE THE ACUTE KIDNEY INJURY IN PATIENTS WITH POISONING
Authors: KATARIA DHARMENDRA , TOMAR MUKESH SINGH , CHAREL KAILASH
Published: October 2022

Objective: The goal of the study is to determine the pattern of dangerous material presence in the field, as well as how severely it affects kidney function and can result in death.
Methods: An observational study of patients hospitalized to the poison ward of tertiary care hospitals of Gwalior was planned. For data collection a structured questionnaire was used, which includes questions on demographic information, details of poisoned intake, and the time interval between ingestion and hospital admission.
Results: There are 79 instances of Celphos poisoning, 157 cases of organophosphorus poisoning, 67 cases of hair dye poisoning, 58 cases of rat killer poisoning, 51 cases of acid or alkali ingestion, 28 cases of alcohol intoxication, and 14 cases of Ethylene dibromide poisoning. Organophosphorus poisoning has the highest number of instances (157), whereas ethylene dibromide poisoning has the lowest number (14). Except in the situations of acid/alkali ingestion and ethylene dibromide ingestion, where the age range of 26–40 years was more involved, the majority of serious cases were in the 10–25 year old age group. Poisonings show male dominance over female dominance. Almost all poisonings result in a deranged renal profile; however, ethylene bromide poisoning has the greatest rate (21.4%), whereas celphos poisoning has the highest rate (28.37%) in terms of term mortality.
Conclusion: The findings show that organophosphorus toxicity, celphos poisoning, hair dye, and rat killer are all prevalent in Gwalior and the nearby region. Acute kidney damage was also detected in hair dye, celphos, organophosphorus, rat killer, and ethylene dibromide poisonings, with ethylene dibromide being the most common. Finally, celphos and Ethylene dibromide poisoning had the greatest fatality rates.
A COMPARATIVE STUDY OF FETOMATERNAL OUTCOME IN WOMEN WITH OLIGOHYDRAMNIOS INDUCED WITH MISOPROSTOL
Authors: BHATI ANJLINA , NAGAR JYOTI , MAYANKJAIN  , RAHAR MONIKA , SURENDRASINGH  , RAVIKRISHAN AISHWARYA
Published: October 2022

Objectives: The objectives of this study were to compare the effect of misoprostol on fetomaternal outcome among women with oligohydramnios and normal amniotic fluid.
Methods: An intervention study was carried out at Obstetrics and Gynecology Department of Jhalawar Medical College during September 2021–February 2022. Based on inclusion and exclusion criteria, 42 women with oligohydramnios at term gestation (Group I) and 42 matched control (Group II) were enrolled in the study. All women were undergone for induction of labor using 50 microgram misoprostol. Data were entered and analyzed using SPSS 23.0 software.
Results: Mean age of Group I was 25.9±4.3 and Group II was 26.4±5.8 years. Nearly, equal dose of misoprostol was required to induce labor in both groups (p=0.28). Induction to delivery interval was significantly different (p=0.0001) in both group. Vaginal or assisted vaginal delivery was occur in 26 (61.90%) and 23 (54.76%) in Group I and Group II. Meconium staining was found significantly higher (p=0.033) among Group I (13, 30.95%) than Group II (05, 11.90%). APGAR score <7 at 1 min was found in 11 (26.19%) in Group I and 04 (9.52%) in Group II p=0.046).
Conclusion: Labor induction at term with misoprostol in both groups did not show significant difference as far as maternal outcome was concerned, although it does affect neonatal parameters in terms of meconium staining and APGAR score.
LIP-PRINTS – EVIDENCE LOST TO IMPERTINENCE
Authors: CHHIKARA PANKAJ , SINGH ABHISHEK
Published: October 2022

Objective: Identity means determination of individuality of a person beyond doubt, based on physical characteristics unique to an individual. Article-6 of the Universal Declaration of Human Rights states that everyone has a right to identity as a person. The wrinkles and grooves on labial mucosa called form a characteristic pattern and the study of these is referred to as cheiloscopy. These are unique to an individual just like the fingerprints thus, hold the potential for identification purpose. This study was designed to evaluate lip-prints as a tool of forensic identification.
Methods: The study was done in North Haryana on 1000 subjects aged between 15 and 25 years over a period of 2 years. Purposive sampling was done and subjects were asked to produce lip prints on bond paper, which were examined based on Suzuki and Tsuchihashi classification. Data obtained were analyzed using Student’s t-test.
Results: It was found that no two individuals had similar lip prints. Type I pattern was most common followed by Type II whereas Type V was least common.
Conclusion: However, till date, no reliable system with repeatability has been developed for studying lip-prints especially to remove observer bias. Nor any comprehensive studies are available comparing lip-prints in live and dead subjects to authenticate their forensic identification potential, raising question at forethought and purpose of practical application of research in the field of cheiloscopy.
Improving Production and Business efficiency for Pear Products of Lai Chau Province
Authors: Thuy Nguyen Thu , Tinh Duong Thi , Long Nguyen Tien , Ngo Huong Tan Thi
Published: October 2022

Conducting a survey of 200 questionnaires with contents related to evaluating the efficiency of pear production and trading in Tam Duong district, Lai Chau province, the authors found that pear tree is a suitable crop. In accordance with the soil and climate conditions in Tam Duong district, the productivity is the highest compared to other districts of Lai Chau province. The average profit is more than 21,000 VND/kg, so people are expanding the new planting area. However, the added value of pear trees in Tam Duong district is very low, mainly selling fresh fruit, processing activities are almost nonexistent. Using the SWOT analysis method, the authors have synchronously built strategic groups according to each content with the aim of improving the value of crops, increasing income for farmers and sustainably developing pear trees on the land of Tam Duong district, Lai Chau province
Modeling and performance optimization of starch-based biocomposite films using response surface methodology
Authors: Mittal Mohit , Chaudhary Rajiv , Phutela Kanchan , Airon Mukta , Singh R.C.
Published: October 2022

The primary objective of this study is to optimize the significant parameters (filler type, filler size, and content) for improving the performance of starch-based biocomposite films. The mathematical and statistical tools such as response surface methodology (RSM) and analysis of variance (ANOVA) were employed for modeling and optimization. To verify the different developed models, validation tests were also performed. The results showed that the RSM based central composite design (CCD) is an effective tool to predict the relationship between various input parameters and desired responses. Most of the desirable properties [Tensile strength, Young’s modulus, impact strength, water vapor transmission rate (WVTR), and opacity] of starch-based films were improved with the increase of filler content. The optimum values of input and response parameters are: filler content: 8.11 wt.%, filler size: 27.07 µm, filler type: walnut shell, tensile strength: 32.43 MPa, Young’s modulus: 333.338 MPa, elongation at break: 9.90 %, impact strength: 34.12 J/mm, WVTR: 1040.40 g m-2 24 h-1, ROD: 31.6918 weight loss%/day, transparency 58.60 %transmittance/mm, and solubility 27.06%.
Reflection on Clinical Decision Science: The decision I never thought I would have to make
Authors: Nixon Mary
Published: October 2022

A brief essay on how the COVID pandemic has changed how we think about medicine and our patients.
From The Editor: Understanding how Social Determinants of Health are integrated within Clinical Decision Science
Authors: Meza James P. , Yee Nicholus H.
Published: October 2022

The editors reflect on the effect of Social Determinants of Health in Clinical Decision Science on questions of efficacy and effectiveness.
GAZİANTEP ALEVİ KÜLTÜR DERNEĞİ DİNİ RİTÜEL VE MÜZİKLERİ
Authors: KURT Bayram , AKGÜN Şakir Orçun , KARABURUN DOĞAN Derya
Published: October 2022

Türkiye’de sanayi, ticaret, gastronomi ve kültür-sanat anlamında önemli bir yere sahip olan Gaziantep nüfus bakımından da Türkiye’nin en büyük dokuzuncu ili olma özelliğine sahiptir. Birçok kültür ve medeniyete ev sahipliği yapmış olan Gaziantep günümüzde hala çeşitli kültürleri içerisinde barındırmaktadır. Anadolu coğrafyasında birçok ilde bulunduğu gibi Gaziantep ilinde de Alevi-Bektaşi cemaatinin varlığı bilinmektedir. Bu çalışmada Gaziantep merkez ilçesi olan Şehitkamil ilçesinde varlığını gösteren Cem evi baz alınarak, buradaki Alevi-Bektaşi cemaatine ait sosyo-kültürel yapının, cemaatin inanç sisteminin dini ritüelleri ve bu ritüellerde kullandıkları müziklerin içeriğine yönelik tespite yer verilmiştir.

Bu çalışma nitel araştırma yöntemlerinden kültür analizi modeli ile gerçekleştirilmiştir. Bahsi geçen Cem evinde bulunan cemaatin müziği ile birlikte “Dini ritüel ve Müzik kültürü” üzerinde durulmuştur. Bu bağlamda burada dini ritüeller uygulanırken bu ritüellerin ne şekilde olduğu ve ritüeller uygulanırken icrası gerçekleştirilen eserlerin form ve repertuvar analizlerine yer verilmiş olup deyişlerin makamsal özellik taşıdığı sonucuna varılmıştır.
A study on the Architectural Characteristics of Sou Fujimoto in Ecological Thoughts
Authors:   Residential Environment Institute Of Korea, Lee Sang-Hwa , Lee Seong-Go
Published: October 2022

In the 21st century, the ecological crisis has become a problem that cannot be left unattended any longer, and it is necessary to present and implement solutions in terms of science, technology, industry, and systems from the academic, industrial, national, and global perspectives.
In the field of architecture, the concept of ecological architecture was proposed in Germany in the 1970s. In the 1990s, Japan established Symbiotic Housing. The American Architects Association (AIA) established the Environment Committee in 1989 and the Green Building Committee in 1993, starting the Energy and Environmental Design Program in 1998.
In this study, researchers will examine the principles and concepts of architectural composition in terms of ecological ideas, and examine the orientation points not only in terms of overcoming the ecological crisis of the artificial environment but also in terms of emotion.
By analyzing 33 design concepts and 34 housing cases presented by Fujimoto architects based on social ecological classification, researchers will grasp the ecological meaning of primitive future, weak architecture, and natural motifs.
In this study, social ecology and Fujimoto architecture are considered relatively in life philosophy, and since the 1990s, environmentally friendly architecture has been developed numerically and technically while emphasizing sustainability as eco-friendly. However, further research was conducted, considering the importance of ecological perspectives in a more fundamental, fundamental and conceptual way. Therefore, it is thought that the ecological crisis can seek sustainability in terms of numerical and technological aspects.
Regional Determinants of Sale Price through Small Office Building Sales Cases: Focusing on the analysis of sales cases in Seoul
Authors:   Residential Environment Institute Of Korea, Jung Kwang Hwa , Lee Myeong Hun
Published: October 2022

In this study, to analyze the regional determinants of small office building sales prices, the analysis was conducted based on the Hedonic model using building characteristics, location characteristics, and economic characteristics as dependent variables. As a result of examining the hypothesis set for the study by variable characteristics, first, CBD, YBD, and Others, which are characteristics of each region excluding GBD (Gangnam area), were found to act on regional decisions as factors that lower the sales price of small office buildings. Second, it was found that the land area, access road area, and use area had a significant effect in the relationship between the location characteristic factor and the sales price determinant, and it was verified that the subway station had no significant effect. Third, among the building characteristics, the number of parking lots, floor area ratio, and elevator presence indicated a positive (+) direction in determining the office building sales price, the building year was identified as a negative (-) direction, and the total number of floors was verified to have little effect on the sales price. Fourth, economic characteristics were found to have a statistically significant effect only on the linear regression model of Model 1, and in the case of Model 2, it was found that there was no influence in the analysis of regional determinants of the sale price of small office buildings.
Study on the Estimation of House Market Fundamental Price by Region
Authors:   Residential Environment Institute Of Korea, Park Heon Soo , Kim Soon Yong
Published: October 2022

In this study, the market fundamental price of house price was estimated from August 2001 to April 2022 in based on the present value model and compared with the actual house sale price.
As a result, First, the pattern of the difference between the actual housing sale price and the market fundamental price of each model was similar in other regions except Incheon, and although it was not exactly the same, it was divided into four periods. Second, The market fundamental price of houses estimated according to the three models showed different volatility by period and region. Third, the estimate of the third model showed less volatility compared to the estimates of other models and closely followed the actual apartment sale price. Fourth, Factors the interest rate and rent growth rate which are factors constituting the market fundamental price had different effects depending on the period.
A Study on the Demand Characteristics and Selective Factors of Public Housing for Sale
Authors:   Residential Environment Institute Of Korea, Kim Tae Ji , Kang Jeong Gyu
Published: October 2022

This study aims to propose a policy for improving the quality and expanding supply of public housing for sale by finding problems and improvements in public housing for sale by studying the demand characteristics and selection factors on the part of public housing for sale buyers.
The results of the empirical analysis are as follows: First, the perception of public housing for sale was positive and the reason was because of its low selling price. As for the perception of brand image of public housing for sale, brands of private construction companies are preferred the most because of their higher value investment. As for the preferred housing area for public housing for sale, it was found that medium-sized housing was more preferred than small-sized housing. The selection factors of public housing for sale were convenience of transportation, high investment value, convenience of parking space, and excellent educational environment.
Second, in case of the residential satisfaction, it turned out that residents feel generally satisfied with residence at above-average points. The reasons for satisfaction were in the order of ‘environmental friendliness,’ ‘high brand recognition,’ and ‘high investment value.’ On the other hand, the reasons for dissatisfaction were in order of ‘convenience of parking space,’ ‘convenience of traffic,’ and ‘excellent educational environment.’ The factors to be considered to improve the residential satisfaction were shown in order of ‘convenience of transportation,’ ‘excellent educational environment,’ and ‘convenience of amenities.’
Third, survey participants agreed on the necessity of expanding the supply of public housing for sale on some levels at above-average points. The items to be considered when supplying public housing for sale were ‘convenience of transportation,’ ‘excellent educational environment,’ and ‘convenience of using convenience facilities’ in their order. This is the same as the ones to be considered to improve residential satisfaction. In addition, the most common area of housing that needs to be expanded is 'more than 74㎡ to 85㎡,‘ the same as the preferred area of housing.
Design of quantum optical experiments with logic artificial intelligence
Authors: Cervera-Lierta Alba , Krenn Mario , Aspuru-Guzik Alán
Published: October 2022

Logic Artificial Intelligence (AI) is a subfield of AI where variables can take two defined arguments, True or False, and are arranged in clauses that follow the rules of formal logic. Several problems that span from physical systems to mathematical conjectures can be encoded into these clauses and solved by checking their satisfiability (SAT). In contrast to machine learning approaches where the results can be approximations or local minima, Logic AI delivers formal and mathematically exact solutions to those problems. In this work, we propose the use of logic AI for the design of optical quantum experiments. We show how to map into a SAT problem the experimental preparation of an arbitrary quantum state and propose a logic-based algorithm, called Klaus, to find an interpretable representation of the photonic setup that generates it. We compare the performance of Klaus with the state-of-the-art algorithm for this purpose based on continuous optimization. We also combine both logic and numeric strategies to find that the use of logic AI significantly improves the resolution of this problem, paving the path to developing more formal-based approaches in the context of quantum physics experiments.
Directions for improving the economic regulation of the State Defense Order
Authors: Rogatin S. I.
Published: October 2022

Since February 2022, the Russian economy has been developing in the changed external political and economic conditions, determined by sanctions pressure from the “collective West”. The purpose of imposing sanctions is to weaken the Russian economy and force the political leadership of our country to make decisions in the military, social and economic spheres that do not reflect the national interests of the Russian Federation. The negative impact of sanctions on the national economy and new threats to national security, including in the military sphere, are today forcing us to reconsider approaches to regulating the activities of enterprises in the military-industrial complex, which are the economic basis for ensuring Russia’s military security. The author proposes to do this through the institutional modernization of the State Defense Order system, considering existing experience and decisions already made during 2022. The article discusses some of the most significant (according to the author) directions for improving the regulation of economic relations in Russia in the field of the State Defense Order and proposes adjustments to the rules for regulating economic activity in military-economic relations.
Sociological measurement of user reaction to Instagram blocking: expert assessment
Authors:   Regional Clinical Psychiatric Hospital named after Professor I.B. Galant, Lukina K. V. , Shirokova A. S. ,   Far Eastern State Medical University, Zakharycheva T. A. ,   Far Eastern State Medical University
Published: October 2022

Social networks have become an integral element of modern life and are a tool for making public opinion. Today, without them, communication and development of creative potential of the individual is unthinkable. This study was aimed at studying psychological adaptation of the followers of two Instagram accounts to the blocking of this social network. The subject of this study was the information (opinion of followers) received during the first day after blocking Instagram. As a research method, we used a sociological survey in «stories» using a questionnaire that included three questions with four answer options. The mental status and emotional state of the subscribers were also assessed by their further personal interviews. The first account was presented with 10,000 followers, the second with 9,100 followers in the age range from 25 to 55 years old. Less than 10% of the followers took part in the examination. However, most of them refused to be surveyed. It was found that the blocking of Instagram was accompanied by a distress of the usual emotional-informational and supportive space – emotional reactions with a high degree of stress response, loss of social recognition, ways of obtaining it, implementation, monetization, up to a failure of adaptation in some content consumers. In the compared groups, differences were found in such indicators as anxiety, fear, anger, apathy and loss of strength. There were also found differences in reaction to future building, which requires further study. The obtained data on the reaction of subscribers of specific accounts can be extrapolated to other accounts and social networks, as reflecting the process of mediatization of social space, including professional space.
Инновационные публично-правовые режимы в стратегическом развитии российского Дальнего Востока: мера должного в глубинных логистических и парадигмальных подходах
Authors:   The Government of the Khabarovsk territory, Degtyarev M. V.
Published: October 2022

The article is devoted to the issues of deep logistical and paradigm approaches in planning, programming and predictive design of measures and scenarios for development of the Russian Far East. The author addresses the subject of regulatory experiment and iteratively adaptable regulation. The article presents the author's definitions of the concepts of «regulatory experiment» and «iteratively adaptable regulation». The author articulates a certain objective difficulty in creating an ideal regulatory toolkit (for a long design period of operation), which determines the need to turn to regulatory experimental approaches and technologies. The legislator, who has designed a good (in his opinion) regulatory toolkit, begins to test it in real conditions, and not on paper, or in the head (mentally) or in a computer. According to the author, the latest paradigmatic and instrumental-technological approaches associated with testing, experimental “running in”, with an iteratively adaptable approach based on handling regulatory landscapes, with regulatory spaces, allow them be transformed in the most gentle way in the right directions. These approaches make it possible to fill in gaps and eliminate other defects. However, the identified certain timidity before experimenting in the field of law, therefore, is rooted in the shortcomings of legal education. This is also due to the fact that the technologies and tools of the regulatory experiment and iteratively adaptable regulation, the innovative public law regimes built on them, do not find concretizing explanations in the specialized literature, knowledge about them is not generalized and transferred properly. During preparing the study, classical general scientific methods of analysis and synthesis, induction and deduction, classification and modeling, as well as scientific legal methods of formal, teleological (target) and specific historical interpretation of law were used as the main ones. The legislation and experience of law enforcement practice in Russia and several dozen foreign countries are taken as an empirical and other source basis for the study. The result reflected in the article completes the author's scientific theory, reflected in his scientific monographs, adapts this theory to Russian reality.
Factors affecting the choice of governance structure along the vegetable value chain in Bangladesh
Authors: Sharma Dabasis , Alam Mohammad Jahangir , Begum Ismat Ara , McKenzie Andrew M.
Published: October 2022

Analyzing governance structure is considered important when designing development interventions in the value chain. The objective of this paper was to explore the governance structure (GS) in cauliflower and tomato value chain, specifically the types of GS followed by the farmers and factors behind these choices. The two-stage random sampling procedure was used to collect data from 100 farmers whereas 60 traders were surveyed purposively for this study. Multinomial logit model was used to analyze the factors affecting farmer’s choice of GS. Trader’s perceptions regarding internal and external governance as well as good governance indicators were assessed by utilizing non-parametric test. Cauliflower and tomato farmers were involved in practicing spot market, relational, farmer’s association and outgrowing scheme-based GS. The results showed that the probability to choose relational, outgrowing scheme and farmer’s association-based GS were significantly affected by education of farmers, distance to the nearest market, access to extension services, access to price information, trust commitment, transaction specific investment, preferences of diversification, farm size, transactional uncertainty, and access to producer’s cooperative. Wilcoxon-Mann-Whitney-U test established trader’s dissimilation towards governance indicators. The study suggests that smallholder farmers need to be well organized and coordination mechanisms among all stakeholders should be increased.
Analisis Pencapaian Ḥifz al-Nasab Terhadap Enakmen Kesalahan Jenayah Syariah Berdasarkan Kaedah Fuzzy Delphi
Authors: Wan Halim Wan Mohd Amjad , Desa Rohani
Published: October 2022

Islam is a religion that upholds the values of security, well-being and prosperity. Similarly, punishment in syariah is stipulated to preserve human welfare. The Syariah Criminal Offenses Enactment has been provided to curb the problems and issues of syariah crime in Malaysia. The maximum punishment for adultery and crimes that can lead to adultery such as “muncikari” (pimp) and khalwat (close proximity) in the Syariah Criminal Offenses Enactment is generally three years imprisonment, six lashes and a fine of RM5,000. Looking at the cases involving syariah criminal offenses, especially crimes involving adultery, it is more worrying. The proof can be seen based on the statement by the then Minister of Women and Community Development, Datuk Seri Rohani Abdul Karim in 2017 that more than half a million illegitimate children are registered with the National Registration Department. Therefore, this paper aims to examine the consensus of expert groups on the achievement of maqāṣid al-sharī’ah, especially ḥifz al-nasab in the maximum punishment. The researcher adopted the Fuzzy Delphi analysis method by conducting a survey on 20 expert informants to get consensus from them. This study also contains one element consisting of six items to obtain consensus from study experts. The study concluded that 20 informants of the study experts agreed that the maximum sentence of 3 years imprisonment, 6 lashes and a fine of RM5,000 did not comply with maqāṣid al-sharī’ah, especially the maslahah of ḥifz al-nasab. This agreement involves punishment for the offenses of adultery, qazaf (false accusation of adultery), prostitution, pimp, khalwat, sodomy and musahaqah (sexual intercourse between two women). The group of study experts gave a consensus that the punishment is too low to curb the crime and therefore it does not achieve maqāṣid al-sharī’ah. Therefore, punishments that are more in line with the essence of maqāṣid al-sharī’ah should be implemented such as the enforcement of hudud or at least the implementation of bill 355 proposed amendments in 2021 (thirty years imprisonment, fine of RM100,000 and one hundred lashes).
Arkady the Deathless (Dostoevsky on the External Soul)
Authors:   Boston University, Corrigan Yuri
Published: October 2022

This essay examines Dostoevsky’s Adolescent from the point of view of its young protagonist’s attempts to hide his “soul” in a series of locations (in objects, ideas, and people) as a means of self-defense or selfpreservation. The novel’s plot follows the gradual loss and desolation of Arkady’s hiding places and, in this sense, constitutes an unorthodox contribution to the modern European tradition of the novel of personal formation, or bildungsroman. Rather than depict, in The Adolescent, the formation of a personality, the transition from unsteady youth to firm adulthood, Dostoevsky follows the gradual unraveling and stripping away of the trappings of identity. In developing a new understanding of the novel’s psychological arc, the essay challenges the critical reception of The Adolescent as chaotic and incoherent in its plot structure.
The Legend of Rothschild as the “Napoleon of Finance” in Dostoevsky’s Works
Authors:   Novgorod National University Yaroslav Mudryi, Podosokorsky Nikolay N. ,   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences
Published: October 2022

The paper analyses the legend of the mighty financial dynasty of Rothschilds who exerted great influence on business life, politics, and culture in 19th-century Europe. Dostoevsky considered the motif of the power of money and Mammon’s greatness as one of the severest problems of his time, “a cruel time, a time of business and money, a calculating time, full of tables, numbers, and zeros of all kinds and types”. From his earliest works, Dostoevsky relates the Napoleonic idea with the idea of monetary enrichment (“Mr. Prokharchin”, “Uncle’s dream”, Crime and Punishment, and others). However, in his early works, the names of Rothschild and Napoleon evolved in parallel, and finally merged only in his novels The Idiot and The Adolescent.
The Problem of Beauty and Female Characters in Dostoevsky’s Novel The Adolescent
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Bogdanova Olga A.
Published: October 2022

During his career as a writer, the problem of beauty was solved by Fyodor Dostoevsky from different points of view, quite always through female characters. In The Adolescent, Dostoevsky combines the Schillerian, Renaissancehumanistic ideal of beauty as “normality” and “health” which was close to him from his youth thanks to the Russian Orthodox tradition and comes to the conclusion that “living life”, embodied in Katerina Nikolaevna Akhmakova, has the right to imperfection and error in the fallen earthly reality. This emerging type of Russian woman, according to the writer, should abandon the established role of “slave” or “goddess” and develop a partnership between the sexes. Furthermore, Dostoevsky offers a Christian nterpretation of the female ideal presented by Nikolay Chernyshevsky in the novel What Is to Be Done? In the novel, Sofia Dolgorukaya is regarded as the embodiment of the best national features: integrity, humility, and sacrifice. Since, according to Dostoevsky, Russian people are gradually losing these qualities, the heroine is called “the last angel”. Trying to understand the relationship between his parents, at first Arkady Dolgoruky notices the “humane and universal” nature of Versilov’s love for “mom”. Gradually, another reason for his attachment is revealed: the admiration for the wife’s firmness and inner strength due to her belonging to the people and their Orthodox “tradition”. The relationship between Sofia and Versilov reflects as in a drop of water the tragic collision of the Petersburg period of Russian history: the cultural and moral gap between the people and the educated class and at the same time their mutual attraction to each other. Versilov is a bearer of the Western European Modern culture, while Sophia holds to a patriarchal Russian tradition focused on Orthodox values. The common denominator of both worlds is the old ideal of “godliness”, that all the characters of the novel strive to reach. However, the ideal in its former form is now irretrievable, as Dostoevsky attests through the fate of Versilov, Akhmakova, and Sofia.
The Theme of Lawyers in Dostoevsky’s Novel The Adolescent
Authors:   Fyodor Dostoevsky’s Museum in Staraya Russa (Branch of the Novgorod State United Museum-Reserve), Yukhnovich Yulia V.
Published: October 2022

The article considers the key aspects connected with a denunciatory judgment on the judicial system of the 1860s-1870s and its main organ, the Advocacy, as reflected in Dostoevsky’s novel The Adolescent. At the time of its creation, the writer has turned to a large number of lawyers in connection with his involvement in the complex and tangled case of obtaining the inheritance of his Moscow aunt Aleksandra F. Kumanina. Almost all of them were found to have committed fraud, which harmed the outcome of the proceedings. His unfortunate experience with the lawyers in the Kumanin estate case led Dostoevsky to develop a new theme that shows the writer’s ambivalent attitude towards the judicial system in general and the legal profession in particular. This critical stance found expression not only in the pages of his journals and letters but also in the creative works of this period, including The Adolescent.
Аркадий Долгорукий в кино и на сцене: дебютные решения
Authors:   State Institute for Art Studies, Saraskina Liudmila I.
Published: October 2022

The paper investigates the fate of Fyodor Dostoevsky’s novel The Adolescent in cinema and theatre, comparing it with the stories of several film and stage adaptations of other works by the same author. The problem here discussed concerns the acceptable limits of interpretation, in cinema and theatre, of a literary work. The paper considers the following controversial aspects: — to what extent film and stage adaptations of a literary work may prove the success of the work as a piece of literature? — do film and stage adaptations expand (amplify) the contents of their literary source? — do they treat honestly the ideas and images of their source? The paper analyses the reasons why both cinema and theatre for many decades did not pay attention to The Adolescent and perhaps even deliberately bypassed it. The only film adaptation of The Adolescent so far was made in USSR in 1983 by the director Yevgeny I. Tashkov, with Andrei Tashkov as Arkady Dolgoruky and Oleg Borisov as Andrei Versilov. Of particular interest is the process of transforming the novel first-person narrative (Ich-Erzählung) into the language of cinema. However, the cinema debut of the novel and its characters cannot be described as a success. The film freed itself from the meaningfulness of the literary original, did not treat adequately its main ideas, and chose easy ways in all respects: in the script, the work of the director, and the actors’ performances. Still more simplified has been the stage adaptation of The Adolescent at the Maly Drama Theatre in Saint Petersburg (the premiere took place on May 12, 2013). The director Oleg Dmitriyev, a disciple of Lev Dodon, abridged considerably the plot of the novel. The character of Versilov was deleted, shifting accents, and disfiguring the whole composition of the plot. In the novel, Arkady had dreamed all through his youth to come to know “the whole truth” about Versilov. In the stage adaptation, Arkady is presented not as a young and maturing person, but as a grown-up man who goes through a “middleage crisis”: he turns into Versilov himself. He appropriates Versilov’s right to be extravagant and scandalous, thus playing the role, not of a witness but the central figure in the culmination of the story.
I.A. Bunin and A.N. Tolstoy: to the History of Relations
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Vorontsova Galina N.
Published: October 2022

Ivan Alekseevich Bunin and Alexey Nikolaevich Tolstoy are contemporaries. Their life and creative destinies have repeatedly intersected, while human relations have not always been simple. Nevertheless, they clearly had a mutual interest in each other. Even during his lifetime the works of Bunin and Tolstoy were compared by criticism, which intuitively felt a certain proximity of their themes and motives. The article traces and analyzes the formation and development of relations between the two writers over several decades, the commonality and at the same time the difference in their views on the events in Russia at the turn of the 1910–1920s, creative roll calls. The basis for the analysis was the works of Bunin and Tolstoy, their letters, as well as letters and memoirs of their contemporaries.
“I am a poet mainly…” (Ivan Bunin: the Poetry at the Break of the Epochs)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Chagin Alexei I.
Published: October 2022

The article is devoted to the poetry by I.A. Bunin, which was considered by the author himself as the significant part of his creative activity. I.A. Bunin didn’t accept division of literature into verse and prose and published in his books the poems near the prosaic works. The way of Bunin’s poetry is being examined at the article — which doesn’t lay claim to be an exhaustic historical survey — in its entire length, from the early works from the book of collected poems “Listopad” (“Fall Of the Leaves”) till the last poems. Examination of concrete works shows obviously how the movement of time, the epoch of historic cataclysms in Russia in the XXth century were reflected in Bunin’s poems and largely determined the directions, turns of his poetry. The figure of the writer who has became for his contemporaries the embodiment and stronghold of the classic literary tradition, the invariable and irreconcilable opponent to the modernist trends — in particular, to Russian symbolism — appears here in deep relationships to the experience of modernism and, first of all, to the discoveries of Russian symbolism. The analysis of concrete poetical works which were created both in the beginning of the literary way and in emigration, testifies to the fact that the author of the works never saw himself privy to any concrete trend in literature, always overgrew these limits, resisted to the attempts of some critics who tried their best to “lay” him on “any definite shelf ”.
“Short Stories” by I.A. Bunin. Creative History of the Cycle
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Morozov Sergey N.
Published: October 2022

I.A. Bunin’s cycle “Short Stories” has repeatedly become the subject of consideration by philologists and linguists as a whole, and his individual stories have also been studied. However, the authors of the works primarily studied the poetics of the stories in this cycle. This article examines for the first time the textual structure of I.A. Bunin’s “Short stories” and the creative history of the cycle. On the basis of archival materials (manuscripts, typescript with author’s corrections, newspaper clippings with corrections by the author) and printed texts (all stories were published during his lifetime) discusses the history of the “Short Stories”, a gradual unification of their author in a big cycle. Critical reviews of these stories are also presented, and quotes from articles and reviews clearly show how enthusiastically these innovative works of the writer were perceived by the critics. The article consistently examines autographs, typewriting, and all publications of 45 stories included in this cycle. Examples of changes made by the author to the texts of stories in different publications are presented selectively. These examples of discrepancies show the careful and constant work of I.A. Bunin on the texts of these stories. In conclusion, we consider the choice of the main text and composition of the publication of the cycle “Short stories” in the future scientific Complete works of I.A. Bunin.
Optimization of the in-silico mate-pair method improved contiguity and accuracy of genome assembly
Authors: Zhou Tao , Lu Liang , Li Chenhong
Published: October 2022

A combination of short-read paired-end and mate-pair libraries of large
insert sizes is used as a standard method to generate genome assemblies
with high contiguity. The third-generation sequencing techniques also
are used to improve the quality of assembled genomes. However, both
mate-pair libraries and the third-generation libraries require
high-molecular-weight DNA, making the use of these libraries
inappropriate for samples with only degraded DNA. An in silico method
that generates mate-pair libraries using a reference genome was devised
for the task of assembling target genomes. Although the contiguity and
completeness of assembled genomes were significantly improved by this
method, a high level of errors manifested in the assembly, further to
which the methods for using reference genomes were not optimized. Here,
we tested different strategies for using reference genomes to generate
in silico mate-pairs. The results showed that using a closely related
reference genome from the same genus was more effective than using
divergent references. Conservation of in silico mate-pairs by comparing
two references and using those to guide genome assembly reduced the
number of misassemblies (18.6% – 46.1%) and increased the contiguity
of assembled genomes (9.7% – 70.7%), while maintaining gene
completeness at a level that was either similar or marginally lower than
that obtained via the current method. Finally, we developed a pipeline
of optimized method and compared it with another reference-guided
assembler, Ragtag. We found that Ragtag produced longer scaffolds (17.8
Mbp vs. 3.0 Mbp), but resulted in a much higher misassembly rate
(85.68%) than our optimized in silico mate-pair method. This optimized
in silico pipeline developed in this study should facilitate further
studies on genomics, population genetics and conservation of endangered
species.
A lentinan-loaded calcium alginate hydrogel with a core-shell structure induces broad-spectrum resistance to plant viruses by activating CML19
Authors: Xiang Shunyu , Wang Jing , Wang Xiaoyan , Peng Haoran , Zhu Xin , Huang Jin , Ran Mao , Ma Lisong , sun xianchao
Published: October 2022

Control of plant virus diseases largely depends on the induced plant
defense achieved by the external application of synthetic chemical
inducers with the ability to modify defense-signaling pathways. However,
most of the molecular mechanisms underlying these chemical inducers
remain unknown. Here, we developed a lentinan-loaded hydrogel with a
core-shell structure and discovered how it protects plants from
different virus infections. The hydrogel was synthesized by adding a
chitosan shell on the surface of the polyanion sodium
alginate-Ca2+-lentinan (LNT) hydrogel (SL-gel) to form a CSL-gel.
CSL-gels exhibit the capacity to prolong the stable release of lentinan
and promote Ca2+ release. Application of CSL-gels on the root of plants
induces broad-spectrum resistance against TMV, TRV, PVX and TuMV).
RNA-seq analysis identified that the calmodulin-like protein 19 gene
(CML19) is upregulated by the sustained release of Ca2+ from the
CSL-gel, and silencing and overexpression of CML19 alter the
susceptibility and resistance of tobacco to TMV. Our findings provide
evidence that this novel and synthetic CSL-gel strongly inhibits the
infection of plant viruses by the sustainable release of LNT and Ca2+.
This study uncovers a novel mode of action by which CSL-gels trigger
CML19 expression through the stable and sustained release of Ca2+.
Cardiac Magnetic Resonance Imaging is a Promising Modality for Left Atrial Appendage Occlusion Planning
Authors: Deshmukh Abhishek , Ward Robert
Published: October 2022

The preprocedural imaging before the left atrial appendage closure
device is critical for selecting the appropriate device for the
appropriate patient. CT scans and TEE have been used in the past for
preprocedural imaging. In this report, the authors used cardiac MRI as a
pre procedural planning tool in the wake of scarcity of contrast
availability.
Safety and Efficacy of AK0529 in Respiratory Syncytial Virus-Infected Infant Patients: a Phase 2 Proof-of-Concept Trial
Authors: Huang Li-Ming , Schibler Andreas , Huang Yi-Chuan , Tai Andrew , Chi Hsin , Chieng Chae-Hee , Wang Jinn-Li , Goldbart Aviv , Tang Swee-Ping , Huang YC , George Shane , Alabaz Derya , Su Siew-Choo , Bruyne Jessie de , Karadag Bulent , Bentur Lea , Gu Feng , Zou Gang , Toovey Stephen , Devincenzo John , Wu Jim
Published: October 2022

Background. Respiratory syncytial virus (RSV) infection is a cause of
substantial morbidity and mortality in young children. There is
currently no effective therapy available. Methods. This was a phase 2
study of the oral RSV fusion protein inhibitor AK0529 in infants aged
1-24 months, hospitalized with RSV infection. In part 1 patients (n=24)
were randomized 2:1 to receive a single dose of AK0529 up to 4 mg/kg or
placebo. In part 2 patients (n=48) were randomized 2:1 to receive AK0529
at 0.5, 1 or 2 mg/kg bid or placebo for five days. Sparse
pharmacokinetic samples were assessed using population pharmacokinetics
modelling. Safety, tolerability, viral load, signs and symptoms were
assessed daily during treatment. Results. No safety or tolerability
signals were detected for AK0529: grade ≥3 treatment-emergent adverse
events occurred in 4.1% of patients in AK0529 and 4.2% in placebo
groups, respectively, and none led to death or withdrawal from the
study. In part 2, targeted drug exposure was reached with 2 mg/kg bid. A
numerically greater reduction in median viral load with 2 mg/kg bid
AK0529 than with placebo at 96 hours was observed. A -4.0 (95% CI:
-4.51, -2.03) median reduction in RSV signs and symptom score from
baseline to 96 hours was observed in the 2 mg/kg group, compared with
-2.0 (95% CI: -3.42, -1.82) in the placebo group. Conclusions. AK0529
was well tolerated in hospitalized RSV-infected infants. Treatment with
AK0529 2 mg/kg bid was observed to reduce viral load and clinical signs
and symptoms.
Empirical landscape genetic comparison of SNPs and microsatellites in three arid-zone mammals with high dispersal capacity
Authors: Skey Ebony , Ottewell Kym , Spencer Peter , Shaw Robyn
Published: October 2022

Landscape genetics is increasingly transitioning away from
microsatellites, with Single Nucleotide Polymorphisms (SNPs) providing
increased resolution for detecting patterns of spatial-genetic
structure. This is particularly pertinent for research in arid-zone
mammals due to challenges associated with unique life history traits,
boom-bust population dynamics and long-distance dispersal capacities.
Here, we provide a case study assessing the performance of SNPs versus
microsatellites in evaluating three explicit landscape genetic
hypotheses (isolation-by-distance, isolation-by-barrier, and
isolation-by-resistance) in a suite of small, arid-zone mammals in the
Pilbara region of Western Australia. Using clustering algorithms, Mantel
tests, and linear mixed effects models, we compare functional
connectivity between genetic marker types and across species, including
one marsupial, Ningaui timealeyi, and two native rodents,
Pseudomys chapmani and P. hermannsburgensis. SNPs resolved
subtle genetic structuring not detected by microsatellites, particularly
for N. timealeyi where two genetic clusters were identified.
Furthermore, stronger signatures of isolation-by-distance and
isolation-by-resistance were detected when using SNPs, and model
selection based on SNPs tended to identify more complex resistance
surfaces (i.e., composite surfaces of multiple environmental layers) in
the best-performing models. While we found limited evidence for physical
barriers to dispersal across the Pilbara for all species, we found that
topography, substrate, and soil moisture were the main environmental
drivers shaping functional connectivity. Our study demonstrates that new
analytical and genetic tools can provide novel ecological insights into
arid landscapes, with potential application to conservation management
through identifying dispersal corridors to mediate the impacts of
ongoing habitat fragmentation in the region.