bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical analysis of a generalized diffuse interface model for the electrical breakdown process
Authors: Ponomarev Andrey Sergeevich , Zipunova Elizaveta Vyacheslavovna , Savenkov Evgeny Borisovich
Published: November 2024

The subject of the present work is a previously suggested generalization of a diffuse interface model describing the development of an electrical breakdown channel in a solid dielectric. Numerical analysis for the model is performed. In the analysis, the stationary distribution of the phase field is found in several characteristic cases of the problem. A modification of the finite volume method is applied so that the numerical scheme is available for determining the boundary conditions at sets of higher codimension in three-dimensional space. At that the solution function is expected to have a singularity at the points of these sets.
Stability of stationary solutions of a diffuse interface model for the electrical breakdown process
Authors: Ponomarev Andrey Sergeevich , Zipunova Elizaveta Vyacheslavovna , Savenkov Evgeny Borisovich
Published: November 2024

The aim of the present work is to study qualitative characteristics and to perform a numerical analysis of a diffuse interface model describing the development of an electrical breakdown channel in a solid dielectric. Stability of the system equilibrium positions is analysed. Conditions for the breakdown channel development from small perturbations of the intact medium are found. A differential scheme for the problem is constructed and investigated, an informative estimate of its stability is given. The obtained theoretical results are validated by a computer simulation.
Gestión docente para el desarrollo de habilidades de resolución de problemas numéricos en física
Authors: Oropeza Villalobos Beatriz
Published: November 2024

La resolución de problemas numéricos en física escolar es un proceso sumamente complejo, en el cual son esenciales las acciones docentes que promueven que los estudiantes mexicanos desarrollen procesos cognitivos y metacognitivos que los apoyen en el proceso de aprender a aprender y convertirse en estudiantes autónomos. Debido a la gran cantidad de factores intervinientes en el desarrollo de la habilidad para la resolución de problemas numéricos, se han elegido dos que se consideran de mayor relevancia y en los que existe un claro ámbito de influencia docente: la comprensión lectora del enunciado y la metacognición del proceso. A partir de la justificación teórica basada en resultados de investigaciones educativas, estos se transforman de lo abstracto a lo concreto y se pone el acento en una orientación en la práctica docente cotidiana mediante acciones concretas y ejemplos. Si bien las acciones aquí esbozadas no solucionan todos los obstáculos que enfrentan los estudiantes ante la tarea de resolver problemas numéricos en física, sí constituyen un elemento que promueve un mejor desempeño metacognitivo y cognitivo. El trabajo descrito en este artículo está orientado a estudiantes de nivel medio superior, sin embargo, las estrategias aquí mencionadas pueden ser útiles para estudiantes de diversos niveles escolares en México.
Psikolojik Dayanıklılığın İş-İş Dışı Yaşam Dengesi Tatmini Üzerindeki Etkisinde İşte Kendini Yetiştirmenin Aracı Rolü
Authors: Ayyıldız Fatma , Baran Hilal
Published: November 2024

Amaç: Bu araştırmanın amacı, psikolojik dayanıklılık ve iş-iş dışı yaşam dengesi tatmini arasındaki ilişkide işte kendini yetiştirmenin aracı rolünü incelemektir.
Tasarım/Yöntem: Araştırmada küme örnekleme ve kartopu örnekleme tekniğiyle Türkiye’nin yedi bölgesinde yer alan devlet ve vakıf üniversitelerinde çalışan 386 akademisyene ilişkin veri Google forms aracılığıyla elde edilmiştir. Elde edilen veriler SPSS 26, Process Makro ve AMOS yapısal eşitlik modeliyle analiz edilmiştir.
Bulgular: Araştırma sonuçlarına göre, psikolojik dayanıklılık, iş-iş dışı yaşam dengesi tatminini ve işte kendini yetiştirmeyi pozitif yönde etkilemektedir. Benzer şekilde işte kendini yetiştirme de iş-iş dışı yaşam dengesi tatminini pozitif yönde etkilemektedir. Ayrıca, işte kendini yetiştirmenin, psikolojik dayanıklılık ve iş-iş dışı yaşam dengesi tatmini arasındaki ilişkide aracılık rolü üstlendiği tespit edilmiştir.
Sınırlılıklar: Örneklemin sadece belirli üniversitelerden oluşması ve akademisyenler dışındaki üniversite çalışanlarının araştırma kapsamına alınmaması ve araştırma verilerinin çevrimiçi toplanarak yüz-yüze görüşmelerin yapılamaması, nitel analiz tekniklerinin kullanılmaması, araştırmaya katılanların sosyal beğenilirlik ve kendini kabul ettirme düşünceleri doğrultusunda cevap verme ihtimallerinin olması, araştırmanın sınırlılıklarını oluşturmaktadır.
Özgünlük/Değer: Ulusal ve yabancı literatürde psikolojik dayanıklılık, işte kendini yetiştirme ve iş-iş dışı yaşam dengesi tatmini kavramlarını bir bütün olarak ele alıp işte kendini yetiştirmenin aracı rolünü değerlendiren herhangi bir çalışmaya rastlanmaması literatürdeki boşluğa işaret etmektedir. Bu araştırmayla söz konusu boşluğun doldurulması ve literatüre katkı sunulması hedeflenmektedir.
Clustering Türkiye's Provinces According to Education Level Indicators with Two-Stage Cluster Analysis
Authors: Tüzüntürk Selim
Published: November 2024

Abstract

Purpose: This study aims to cluster similar provinces of Turkey according to (i) below-high school and (ii) high school and above-high school education level indicators using cluster analysis methods.

Design/Methodology: The annual most recent data for 81 provinces were taken from the education statistics for the year 2022 published on the official website of the Turkish Statistical Institute. A two-stage cluster analysis method was used to identify similar provinces.

Findings: According to indicators of education level below the high school level, the first cluster consists of 17 provinces (Adıyaman, Ağrı, Bingöl, Bitlis, Diyarbakır, Gaziantep, Hakkâri, Kars, Mardin, Muş, Siirt, Şanlıurfa, Van, Batman, Şırnak, Iğdır and Kilis) and the second cluster consists of 64 provinces (other remaining provinces). The 17 provinces in the first cluster are eastern provinces where education needs to be increased. According to the education level indicators at high school and high school level, the first cluster consists of 6 provinces (Ankara, Çanakkale, Eskisehir, Isparta, Istanbul, and Izmir), and the second cluster consists of 75 provinces (the remaining other provinces). The six provinces in the first cluster are western provinces where education is advanced.

Limitations: The limitation of the study is that cluster analyses were conducted for Turkey's 81 provinces and 2022 cross-sectional data.

Originality/Value: The use of the two-stage cluster analysis method, which allows the number of clusters to be automatically determined according to AIC and BIC criteria, unlike the Ward and K-means methods used in cluster analysis, contributes to the original value of the research. Considering that the increase in education benefits people and society, it points out the importance of the study in providing meaningful and valuable information by creating awareness among individuals and policymakers in the relevant provinces by identifying similar provinces with clustering methods.
The Effect of Companies' Internal Control Structures on Their Financial Performance: An Application on BIST-30
Authors: Özkan Özge , Bakan Merve , Şit Ahmet
Published: November 2024

Purpose: The aim of this study was to investigate the effect of internal control structures on the financial performance of firms included in the BIST-30 Index.
Design/Methodology: The data of the firms for the period 2018-2022 were used annually. Return On Equity and Market value to book value were used in the study to represent profitability as dependent variables. The independent variables were the number of audit committee members, the number of internal control reports, the number of audit committee meetings, the number of audit committee reports, and the rate of graduates in the audit board. GMM which is a dynamic panel data analysis technique and Driscoll Kray Regression were used as the method.
Findings: As a result of the findings, it is seen that the ratio of postgraduates on the audit committee, the number of audit committee members and the number of audit committee reports may have an effect on both ROA and PBRD, while the audit firm being a large firm may have an effect only on PBRD.
Limitations: The reason is that the study was applied only to Türkiye and no country comparison was made.
Originality/Value: There are a limited number of studies examining the impact of companies' internal control structures on their financial performance. This study is original in terms of both variables and method.
Enflasyon Muhasebesi Uygulamasının İşletmelerin Finansal Yapıları Üzerine Etkileri: Oran Analizi İle İnceleme
Authors: Akpınar Yusuf , Ciğer Ayşegül , Güngör Karyağdı Nazan , Kaya Ahmet
Published: November 2024

Amaç: Bu araştırmanın amacı, enflasyon düzeltmesi yapılan finansal tabloların, enflasyon düzeltmesi yapılmamış finansal tablolarla oran analizi açısından karşılaştırılmasıdır.
Tasarım/Yöntem: Araştırmada enflasyon düzeltmesi yapılmamış finansal tablolardan elde edilen finansal rasyolarla, enflasyon düzeltmeleri yapılmış tablolardan elde edilen rasyolar karşılaştırılmalı olarak analiz edilmiştir.
Bulgular: Analizler sonucunda; enflasyon düzeltmesi sonrasında işletmenin finansal tablolarının, finansal oranlar açısından yeterli olmamakla beraber önemli ölçüde düzeldiği görülmüştür. Parasal ve parasal olmayan kalemler ayrımından dolayı bazı oranlarda değişme olmaz iken çoğu finasal oranlarda belirgin farklılıklar ortaya çıkmıştır. İşletmenin finansal yapısı daha gerçeğe yakın bir yapıya kavuşmuştur
Sınırlılıklar: İşletmenin finansal tablolarının enflasyon düzeltmesi açısıdan VUK’a göre yapılmış olmasıdır. Ayrıca finansal tablolar sadece oran analizi yöntemi ile karşılaştırmalı olarak analiz edilmiştir.
Özgünlük/Değer: Enflasyon muhasebesinin yeniden uygulanmaya başlamasıyla işletmelerin finansal yapılarındaki değişimi araştırmacılar açısından merak konusudur. Özellikle VUK kapsamında yapılan düzenleme neticesinde işletmelerin finansal yapılarındaki değişimi finansal oranlar açısından göstermesiyle özgün değer oluşturmaktadır.
RESEARCH OF THE DISTRIBUTIONS OF CONTACT PRESSURE AND THE STRESS-DEFORMED STATE OF THE ELEMENTS OF THE STRUCTURES OF THE TORSION SHAFTS OF THE SUSPENSION OF ARMORED VEHICLES
Authors: Tkachuk Mykola , Zinchenko Olena , Grabovskiy Andrey , Tkachuk Mykola , Loznyi Oleg
Published: November 2024

The work demonstrates the need in accounting for the factor of the mutual influence of contact interaction and plastic deformation in the area of the head of the torsion shaft on the strength of the torsion shafts of the suspension of armored combat vehicles in order to achieve improvements in the technical solutions for the elements of the suspension systems of light-armored vehicles, and, accordingly, the tactical and technical characteristics of mobility. An analysis of the effect of varying the properties of materials and the shape of the contacting surfaces on the contact interaction and the stress-strain state of torsion shafts was carried out. In the presence of limitations on the dimensions of the head of the torsion shaft of the suspension systems of lightly armored vehicles, one of the important solutions is the modification of the working surfaces of the spline connection, which makes it possible to reduce the level of contact pressure in the spline coupling on the head of the torsion shaft.
Exploring the Role of the KCNK1 Potassium Channel and Its Inhibition Using Quinidine in Treating Head and Neck Squamous Cell Carcinoma
Authors: Baek Hyun Woo , Han Eunjung , Oh Kyoung Ho
Published: November 2024

Objectives. Our study aimed to explore the role of the potassium channel KCNK1 in head and neck squamous cell carcinoma, focusing on its impact on tumor growth, invasion, and metastasis. We also investigated the therapeutic potential of quinidine, a known KCNK1 inhibitor, in both in vitro cell lines and a zebrafish patient-derived xenograft (PDX) model.Methods. We established primary cell cultures from head and neck cancer tissues and employed the FaDu cell line for in vitro studies, modulating KCNK1 expression through overexpression and knockdown techniques. We evaluated cell migration, invasion, and proliferation. Additionally, we developed a zebrafish PDX model to assess the impact of quinidine on tumor growth and metastasis in vivo. RNA sequencing and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to elucidate the molecular mechanisms underlying the role of KCNK1 in cancer progression.Results. Overexpression of KCNK1 in FaDu cells resulted in enhanced cell migration and invasion, whereas its knockdown diminished these processes. In the zebrafish PDX model, quinidine markedly inhibited tumor growth and metastasis, demonstrating a significant reduction in tumor volume and micrometastasis rates compared to the control groups. The molecular analyses indicated that KCNK1 plays a role in critical signaling pathways associated with tumor growth, such as the Ras and MAPK pathways.Conclusion. Our findings highlight the critical role of KCNK1 in promoting tumor growth and metastasis in head and neck cancer. The inhibitory effect of quinidine on tumor progression in the zebrafish PDX model highlights the therapeutic potential of targeting KCNK1. These results suggest that KCNK1 could serve as a valuable therapeutic target for head and neck cancer, warranting further investigation into treatments that target KCNK1.
Mechanical properties and microscopic damage characteristics of coal-series limestone under real-time coupling effects of high temperature and impact
Authors: wu peng , zhang lianying , li bing , zheng yadong , li ming , zhu fuqiang
Published: November 2024

To ensure the safe extraction of deep mineral resources, it is imperative to address the mechanical properties and damage mechanism of coal and rock media under the real-time coupling effect of high temperature and impact. In this study, the impact tests (impact velocities of 6.0-10.0 m/s) on coal-series limestone under real-time high-temperature conditions (25 ℃-800 ℃) were conducted by the real-time high-temperature split Hopkinson pressure bar (HT-SHPB) testing system, and the microscopic changes in mineral composition under the coupling effect of real-time high-temperature and high strain rate action were investigated by X-ray diffraction (XRD), electron scanning microscopy (SEM), energy dispersive spectroscopy (EDS). The results showed that the dynamic stress-strain curve of coal-series limestone under the real-time coupling effect of high temperature and impact during the compaction stage was not significant; As the impact velocity increases and the temperature increases, the plastic characteristics of the dynamic stress-strain curve become more notable, and the brittle failure of the sample is gradually changed into brittle-ductile failure. Additionally, the dynamic peak stress and dynamic elastic modulus exhibit distinct quadratic variations with the increased temperature, and the dynamic peak stress approximately increases linearly with the impact velocity. The main substances in coal-series limestone are calcite, dolomite, and muscovite. The microscopic morphology of calcite at room temperature is characterized by a thin stepped or layered structure. When the temperature rises to 800 ℃, thermal decomposition rarely occurs in calcite, while its physical and mechanical properties undergo alternations. After real-time impact, the degree of crystal fragmentation of calcite increases and a large number of microcracks are generated. The dolomite exhibits a prismatic microscopic morphology at room temperature, characterized by distinct and flat edges, and typically occurs in clusters. When the temperature rises to 600 ℃, an increased amount of dolomite initiates thermal decomposition, and the crystal edges become passive, even leading to the granulation phenomenon. Consequently, the impact mechanical properties of limestone are ultimately weakened due to the thermal decomposition of mineral components and changes in physical and mechanical properties caused by high temperature.
Injection angles on flow structures and mixing properties in a supersonic combustor at low Mach crossflow
Authors: Zhang Lin , Liang Jianhan , Wang Yi , Zhao Wei , Yang Leichao
Published: November 2024

The fuel-air mixing is of paramount importance in hypersonic air-breathing vehicles, and its performance is closely related to the fuel injection angle. This article presents an investigation into the influence of the injection angles on the flow and mixing processes in a supersonic combustor at low Mach supersonic inflow. Detailed flow characteristics are compared and analyzed, with a focus on instantaneous and average flows. Besides, several significant mixing parameters are thoroughly depicted. Results show that, in contrast to transverse injection, relatively strong fuel fluctuation is presented on the leeward side in comparison to the windward side in the near field for the inclined injection. Furthermore, the counter-rotating vortex pairs (CVP) are constricted by the inclination of the injection, giving rise to a decrease in jet-cavity interaction. Although inclined injection exhibits favorable performance in backpressure resistance at low Mach supersonic crossflow, it presents a greater challenge in terms of ignition, thus necessitating meticulous design considerations.
The impact of family physical education and physical activity on adolescents' social emotional competence: the moderating role of positive youth development
Authors: Zhang Lanxing , Bi XIN
Published: November 2024

Family function theory attests that the role of family in shaping the social emotional competence of adolescents is truly irreplaceable. This study, adopting family function theory and social ecology theory as the analytical framework, delves into the potential mechanism by which family physical education impacts the social and emotional abilities of adolescents. Accordingly, 1,062 students from 19 middle schools in China were selected to examine the role of physical activity and positive adolescent development in the relationship between family physical education and adolescent social emotions. The results indicate that: (1) Family physical education positively predicts the social emotional competence of adolescents. (2) Physical activity serves as an intermediary in the relationship between family physical education and adolescent social emotion competence. (3) positive youth development plays a regulatory role in the relationship between family physical education and the social and emotional competence of adolescents. Thus, parents should be cognizant of the significance of family physical education in cultivating the social and emotional abilities of adolescents. At the same time, families ought to attach importance to the positive development of adolescents, provide them with sufficient support, engage in more physical activities with their children, increase adolescents' participation in physical activities, and ultimately contribute to the improvement of adolescents' social and emotional competence.
Future-Proofing China's Rivers: Balancing Nitrogen Emission Standards Amidst Climate Change
Authors: Wei Chaohai , Guan Hong , Li Zemin , Ru Xuan , Chen Acong , Xie Mengyi , Qiu Guanglei , Hu Yun
Published: November 2024

Despite China taking significant steps to reduce nitrogen input from human activities into inland rivers by raising nitrogen emission standards, climate change has exacerbated the flow of reactive nitrogen, creating additional pressure for nitrogen reduction. To evaluate the necessity and sustainability of these raised standards, this study presents a comprehensive data set summarizing total nitrogen and ammonia concentrations from 1702 sites across 10 major basins from 2015 to 2024. The analysis normalizes factors, including land use, nitrogen deposition, litter, soil leaching, biological nitrogen fixation, and the spatiotemporal fluxes of agricultural fertilization, organized by month within 50 × 50 km grids. Using numerical training, the study assesses the influence of these factors on river nitrogen exposure and predicts changes in river nitrogen levels under four climate change scenarios and three emission scenarios for 2050. The findings indicate that if climate change continues at the current rate (ssp3–7.0), total nitrogen concentrations in rivers nationwide could increase by (6.51 ± 13.68) %. However, raising the total nitrogen concentration standard from 20 mg L⁻1 to 15 mg L⁻1 can reduce the total nitrogen concentration in rivers by (8.22 ± 19.39) %. Nitrogen emission policies should be tailored to specific river basins and seasons. Notably, northern river basins may need to elevate nitrogen emission standards to Class IV to counterbalance the additional nitrogen emissions resulting from climate change.
Health Risks Evaluation of Mycotoxins in Plant-Based Supplements Marketed in Malaysia
Authors: Abdullah Rozaini , Kamarozaman Nur Syazwin , Dullah Siti Soleha Ab , Aziz Mohd Yusmaidie , Adam Aziza Hussein Bakheit
Published: November 2024

Mycotoxins are toxic secondary metabolites produced by fungi, pose significant health risks when present in plant-based supplements (PBS), necessitating thorough risk assessment to ensure consumer safety. This study evaluates the health risks associated with mycotoxins, specifically aflatoxins (AFB1, AFB2) and ochratoxin A (OTA), in PBS sold in Malaysia. Contamination levels of AFB1, AFB2, and OTA were quantified in 14 PBS samples using liquid chromatography-mass spectrometry. All samples tested positive for AFB2, while 28.57% and 42.86% tested positive for AFB1 and OTA, respectively with some levels exceeding the regulatory limits set by the Malaysian Food Act 1983. The estimated daily intake of these mycotoxins was calculated based on the recommended daily intake of each supplement. To assess risk, Margin of Exposure (MOE) values were determined, showing that all AFB2-positive samples had MOE values below the critical threshold of 10 000, indicating an urgent need for risk management. A quantitative cancer risk assessment also estimated the percentage of hepatocellular carcinoma and kidney cancer attributable to mycotoxin exposure. The findings emphasize the significant public health risks posed by mycotoxins, particularly in samples B2 and B10, where all three mycotoxins studied were present at concerning levels. This study highlights the urgent need for stricter regulations and better monitoring of mycotoxin levels in PBS to protect consumers.
Research on the Meso-mechanism of the Evolution of Wet - swelling Cracks in Expansive Soil based on Discrete Element Method
Authors: Ran HAI , Shuoshuo GUO , CHENG Xuelei , LI Qiqi , Xiaofan Xing
Published: November 2024

In order to study the crack evolution law of expansive soil caused by wet - swelling under rainfall conditions, the water migration model corresponding to the heat conduction equation is derived based on the heat conduction theory. Based on PFC, a discrete element numerical model of wet - swelling deformation of expansive soil under the coupling action of humidity and stress is established. The Meso-mechanism of the evolution of wet - swelling cracks is revealed, and the influence law of model parameters on crack development is analyzed. The research found that rainfall infiltration leads to slight wet - swelling deformation of the shallow surface. As rainfall continues further, the surface wet expansion deformation significantly expands to the deep soil layer. However, the depth of soil layer affected gradually stabilizes, and slight uplift and cracks appear in the shallow soil layer. Eventually, multiple through cracks are formed in the foundation and the ground surface significantly uplifts. At the same time, the adjustment of model parameters such as permeability coefficient, tensile strength, elastic modulus and expansion coefficient has a significant impact on cracks development. The research results can not only be used to avoid the problem of expansive soil characteristics, based on the influence of model parameters on the development of cracks, suggestions for foundation improvement of weak expansive soil are put forward, the modification and improvement of engineering foundation provides an important theoretical reference.
Serendipita indica Enhances Growth, Photosynthesis, and Secondary Metabolite Profiles in Acorus calamus
Authors: He Qiang , Yang Yujie , Wu Chu , Liu Jianxiong , Li Hao , Luo Yuexing
Published: November 2024

Aims
Acorus calamus is widely recognized for its therapeutic potential in treating neurological, cardiovascular, and gastrointestinal disorders. Serendipita indica has been shown to promote growth and enhance secondary metabolite production in several plants; however, it is unknown whether S. indica remain beneficial effects on A. calamus.
Methods
A. calamus was cultured in soil with or without S. indica to assess changes in photosynthesis, biomass, and secondary metabolites. The cultivars were grown in a growth chamber in a completely randomized design with two treatment groups: inoculated and non-inoculated, each with three replications. Successful colonization was confirmed microscopically, distinguishing between control (CK) and experimental (P+) groups.
Results
The roots of A. calamus can be colonized by S. indica. Results showed an increase in stem length, creeping stem branches, and root surface area post-colonization after inoculation with S. indica. Meanwhile, the colonization of S. indica in A. calamus roots led to improve photosynthetic efficiency, reflected by increased photosynthetic rate, intercellular CO2 concentration, stomatal conductance, and transpiration rate. Furthermore, among the 170 compounds identified in A. calamus, 25 showed increased levels post-inoculation, including lipids, acids, sugars, amino acids and their derivatives, saponins, phenols, alcohols, flavonoids, aldehydes, sterols, heterocyclic compounds, fatty acid ethanolamides, hydrocarbons, alkaloids, phenylpropanoids, and ketones.
Conclusion
These results underscore the potential of S. indica in enhancing the medicinal properties of A. calamus, suggesting a promising avenue for its agricultural and pharmacological applications.
Chiang Mai VGOS 13m Radio Telescope Remote Health Monitoring System
Authors: Shang-Guan Wei-Hua , Zhao Rong-Bing , Wang Jin-Qing , Li Jin-Ling , Guo Shao-Guang , Jiang Yong-Bin , Yan Zhen , Ba-Shang Fan-Duo , Dai Heng
Published: November 2024

The VGOS 13m radio telescope located in Chiang Mai, Thailand is the first VGOS standard station built overseas by China. This station expands Chinese very long baseline interferometry (VLBI) network (CVN) and furthers multiple scientific goals, such as continuous monitoring of Earth orientation parameters and research into the terrestrial and celestial reference frames. The station is equipped with wideband 2-14GHz receivers and X/Ka dual-frequency receivers, a high-speed antenna, a DBBC3 high-speed data acquisition terminal and a high-speed recording terminal. This is aimed at improving observation efficiency and research quality. We developed the Remote Health Monitoring System (RHMS) specifically for the VGOS 13m radio telescope located in Thailand. This system integrates Tango Controls' distributed middleware technology, allowing it to furnish the observation team with comprehensive historical and real-time status updates for the Chiang Mai VGOS station. Additionally, it promptly issues alerts for abnormalities, thereby improving the station's unmanned monitoring, maintenance and operations capabilities, and operational performance. It also provides a feasible solution for remote monitoring of future overseas VGOS stations.
Comparing the Efficacy and Safety of Remimazolam versus Propofol in Gastrointestinal Endoscopy or Fiberoptic Bronchoscopy: A systematic review and meta-analysis of Randomized Controlled Trials
Authors: Zhang Jie , Ye Ling , Xiang Bangyi , Feng Xixia , Zhou Ruihao
Published: November 2024

Background
While propofol is generally utilized for sedation in endoscopic procedures, its safety has been questioned. Remimazolam, a newer alternative, promises better safety but lacks extensive comparative data. This meta-analysis aims to assess the efficacy and safety of remimazolam in comparison with propofol when used in gastrointestinal endoscopy or fiberoptic bronchoscopy.
Methods
A comprehensive literature search was carried out across PubMed, the Cochrane Central Register of Controlled Trials, Embase, Web of Science, Wanfang, and VIP databases up until October 2023. This search aimed to identify randomized controlled trials (RCTs) that compared remimazolam with propofol regarding to their efficacy and safety in the context of gastrointestinal endoscopy or fiberoptic bronchoscopy. Sedation success rate was the primary outcome while secondary outcomes encompassing additional efficacy measuresand safety parameters
Results
Fifteen RCTs were involved in this study. When compared with propofol, remimazolam displayed a lower success rate of sedation (P < 0.001; I2 = 58%), but featured a reduced induction time (P = 0.0004; I2 = 96%), a quicker return to full alertness (P = 0.001; I2 = 89%), and fewer adverse events (P < 0.001; I2 = 77%). No significant disparities were observed in operation duration, recovery time (P = 0.52; I2 = 92%), or discharge time (P = 0.52; I2 = 86%).
Conclusion
Despite a lower sedation success rate compared to propofol, remimazolam offers significant advantages, including a shorter induction time, a quicker recovery to full alertness, and fewer adverse events. These attributes make remimazolam a compelling alternative for sedation in endoscopic procedures.
Genome wide identification of Plant based natural Antimicrobial Peptides using deep learning approach in Black pepper
Authors: Negi Ankita , Singh Kalpana , Ahmed Bulbul , Jaiswal Sarika , Iquebal Mir Asif , Angadi U. B. , Rai Anil , Kumar Dinesh
Published: November 2024

Background
Black pepper (Piper nigrum, 2n = 52) has been traditionally used for the treatment of various diseases owing to its therapeutic properties, namely, antimicrobial, anti-inflammatory, antioxidant and anti-cancerous properties since time immemorial. Antimicrobial peptides (AMPs) aka ‘nature's antibiotics’ or ‘host defense peptides’ produced by most living organisms as an innate immune response against microbes and have gained popularity due to rising multidrug resistance of microorganisms, new microbial infections, and a great dearth of novel antibiotics in recent years. A Numerous studies are reported on AMPs’ defense mechanism and its different modes of action in animals, showing its immunomodulatory properties and potentiality in combating against multi-drug resistant microbes. But in plants, especially spice crops, like black pepper, that has huge therapeutic properties and potential to improve immunity to combat against microbial infections needed to be further explored.
Result
This study provides a species-specific AMP candidate prediction server BPepAMPred (http://login1.cabgrid.res.in:5040/) based on 10 fold cross validated bidirectional- gated recurrent unit based deep neural network architecture with 99.34% accuracy, 98.68% sensitivity, 98.67% specificity. This server also linked with BPepAMPdb (http://backlin.cabgrid.res.in/blackpepper_amp_db/) which catalogs predicted 43759 AMP candidates across black pepper proteome along with 10935 functionally associated unique genes, chromosome number, genomic location, associated gene ids and functional properties.
Conclusion
The exhaustive molecular information of black pepper crop at one place in the user-friendly way to access would be beneficial for the breeders for black pepper improvement program. It could be utilized by molecular biologists for wet-lab preparation and validation of AMPs which could further be used in the development of novel therapeutic molecule and help to enhance the microbial resistance in black pepper and other crops.
GW8510 alleviated muscle atrophy and skeletal muscle dysfunction in mice through AMPK/PGC1α signaling
Authors: Chen Yutong , Liu Zurui , Liu Chen , Yang Daqian , Xie Zhengwei
Published: November 2024

Background
To prevent and restore muscle loss and function is important for elderly people. Here, we explore the protective effect of GW8510 on muscle atrophy.
Methods
The denervation, dexamethasone, and glycerol-induced muscle atrophy mice were constructed and the ratio of muscle weight to body weight, the cross-sectional area of multiple muscles, grip strength, fatigue task, and serum analysis were assessed. In Vitro experiment, we constructed dexamethasone-induced C2C12 myotube atrophy and evaluated the mitochondrial function. Moreover, we applied real-time polymerase chain reaction, immunoblotting, and transfection with siRNA to investigate the potential molecular mechanism after GW8510 treatment.
Results
GW8510 significantly increases the ratio of gastrocnemius tissue and soleus in denervation mice (6.8% and 3.1%, respectively, P < 0.001), and increased cross-sectional area. Meanwhile, GW8510 significantly improved grip strength and SOD activity (P < 0.0001), and these protective effects were also found similarly in dexamethasone and glycerol-induced muscle atrophy mice. Furthermore, GW8510 reduced reactive oxygen species production (P < 0.01), increased mitochondrial DNA copy number (P < 0.01), maintained mitochondrial dynamics, and enhanced the antioxidation in C2C12 myotubes. Mechanistically, GW8510 significantly inhibited the expression of atrophy-related markers, Fbxo32 and Trim63 (P < 0.01 and activated AMPK (P < 0.01). Knockdown of small interfering RNA abolished the effect of GW8510 and knockdown of Src synergistically reduced atrophy-related protein.
Conclusion
GW8510 alleviated muscle atrophy through activation of AMPK/ PGC1α. Our study identified that GW8510 can be a novel therapeutical agent for preventing muscle atrophy, and Src may be a novel therapeutical target.
Environmental Impact Prediction
Authors: Vivaan Vivaan Kaundinya , Abhi Abhijeet Kant Kumar
Published: November 2024

Predicting environmental impacts is crucial for evaluating and reducing how human activity affects ecosystems, particularly when it comes to pollution, resource depletion, and climate change. In order to predict changes in the environment, this study looks at a variety of predictive models, including both sophisticated machine learning techniques and conventional statistical methods. We provide an integrated framework that increases prediction accuracy by utilizing data from several sources, including satellite images, climate records, air and water quality indexes, and socioeconomic characteristics. Using machine learning models, the study shows improved performance in short-term predictions of water pollution, soil deterioration, and air quality. However, due to data limitations and the complexity of ecological systems, long-term, complicated predictions—like those regarding habitat degradation and biodiversity loss—remain difficult. According to our research, enhancing future environmental effect projections and facilitating more sustainable decision-making processes would need incorporating real-time data, growing datasets, and creating adaptive models.
Using LLMs as AI Agents to Identify False Positive Alerts in Security Operation Center
Authors: Rafiey Pasha , Namadchian Amin
Published: November 2024

This paper addresses the challenges and solutions related to identifying false positive (FP) alerts in Security Information and Event Management (SIEM) systems, which often overwhelm security operators. To tackle this issue, we propose a novel approach that employs a Large Language Model (LLM), specifically Llama, as an AI agent through a contextual-based approach to identify FPs in security alerts generated by multiple network sensors and collected in Security Operations Centers (SOCs). Our method follows three key steps: data extraction, enrichment, and playbook execution. First, Llama normalizes security alerts using a common schema, extracting key contextual elements such as IP addresses, host names, filenames, services, and vulnerabilities. Second, these extracted elements are enriched by integrating external resources such as threat intelligence databases and Configuration Management Databases (CMDB) to generate dynamic metadata. Finally, this enriched data is analyzed through predefined false positive investigation playbooks, designed by security professionals, to systematically evaluate and identify FPs.By automating the false positive identification process, this approach reduces the operational burden on human security operators, enhancing the overall efficiency and accuracy of SOCs, and improving the organization's security posture.
Unveiling Fv1's Potential: Insights into its Interaction with the HIV-1 Capsid
Authors: Dehghani Behzad , Hashempour Ava
Published: November 2024

Virus susceptibility factor 1 (Fv1) serves as the prototype restriction factor guarding against infection by murine leukemia virus (MLV). Analysis of the Fv1 sequences revealed several residues in the C-terminal region that had undergone positive selection during evolution and might have played a role in various retroviral infections. For the first time, various bioinformatic tools have been applied to reveal specific residues involved in the interaction between Fv1 and the HIV-1 capsid as the target. Molecular dynamics (MD) simulation analysis of the Fv1-capsid complex confirmed the stability of the protein-protein complex. Docking and molecular dynamic simulation analyses demonstrated the potential of Fv1 to inhibit HIV-1 infection and supported the possibility that the HIV-1 capsid could be a target for novel anti-HIV medications. Furthermore, we revealed conserved regions, postmodification sites, and secondary and tertiary structures, which provided valuable data about the nature of the FV1 protein.
Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review.
Authors: Moultrie Fiona , Durrmeyer Xavier , Bosch Gerbrich E. van den , Tauzin Manon , Roué Jean Michel , Olsson Emma , Cobo Maria M , Baxter Luke , Iyer Samyuktha , Bhatt Aomesh , Simons Sinno H.P. , Slater Rebeccah
Published: November 2024

The purpose of this scoping review is to assess the risks and benefits of providing analgesic and sedative drugs to ventilated premature infants. We sourced primary empirical research reporting outcomes related to the use of pharmacological analgesics and sedatives in ventilated premature infants. We included articles published in any language in peer-reviewed journals before February 2024 from MEDLINE, Embase, Web of Science, Cochrane Library, and Google scholar databases. Morphine was the most studied drug (39 studies), followed by fentanyl (19 studies). Midazolam (8 studies) and dexmedetomidine (3 studies) were the most frequently studied sedatives. Analgesic efficacy was more consistently reported for fentanyl than morphine. The sedative effect of opioids was rarely assessed. Respiratory, cardiovascular, gastrointestinal, neurological and neurodevelopmental risks were unclear for all opioids. Alternative synthetic opioids and midazolam appear to be associated with significant risks in the absence of clear benefits. Dexmedetomidine shows encouraging but limited results and merits further investigation as an opioid-sparing adjunct. Overall, fentanyl appears to have the best efficacy and safety profile for analgosedation in this patient population. This scoping review will support clinicians in their analgosedative management of ventilated premature infants and identifies research gaps and priorities.
WITHDRAWN: Gas Recycling Optimization in Gas Condensate Reservoirs Using 3D Compositional Modeling
Authors: Kasem Mohamed Raafat , Khattab Hamid Mohamed , Wahba Ali Moustafa
Published: November 2024

Gas condensate reservoirs present unique production challenges due to condensate dropout in reservoir pores when the pressure drops below the dew point. This immobile condensate accumulation reduces well productivity. Dry gas recycling is a widely recognized enhanced production technique to mitigate this issue and maximize condensate recovery. This study employs a three-dimensional compositional model to optimize condensate recovery by varying the gas recycling ratio in reservoirs of different qualities and gas compositions (with varying condensate yields). The analysis considers both vertical and horizontal production well configurations. Initially, a depletion scenario was modeled with five wells producing under natural depletion as the base case. Subsequently, a dry gas recycling process was applied with recycling ratios ranging from 0 to 1, achieved by converting one producer into an injector in a crestal injection pattern. Horizontal wells were also introduced to evaluate the impact of well geometry on recovery performance. The findings indicate that the optimum dry gas injection ratio increases with higher condensate yields. Specifically, the optimal ratio rises from 50% for gas with a condensate yield of 20 STB/MMSCF to 75% for gas with 60 STB/MMSCF. Additionally, reservoir quality and well geometry significantly influence performance. For high-quality reservoirs, horizontal wells outperform vertical wells for high-condensate-yield gas reservoirs. While for low-quality reservoirs: Vertical wells are more effective than horizontal wells for high-condensate-yield gas reservoirs. These results provide guidelines for optimizing dry gas injection ratios across a wide range of reservoir qualities and gas yield contents to maximize recovery.
Stiasny, Philip (2009). Das Kino und der Krieg. Deutschland 1914-1929. München: edition text + kritik. 348 Seiten, 38 €.
Authors: Merz Redaktion
Published: November 2024

Der erste Weltkrieg war einschneidend für die Menschen seiner Zeit – und damit auch für die Medien, damals vor allem das Kino. Philip Stiasny setzt sich in Das Kino und der Krieg anhand überwiegend unbekannter, aber einst populärer Spielfilme mit dem Verhältnis von Kino und Krieg auseinander. Welche Geschichten erzählen die Filme, wie werden sie inszeniert und wie eignet sich das Kino den Krieg als Thema an? In klarer Sprache nähert er sich diesen Fragen. Dazu werden zuerst Filme aus der Kriegszeit betrachtet, danach die Nachkriegszeit sowie Filme mit Szenarien eines zukünftigen Krieges und historische Film behandelt. Dabei erschöpfen sich die Ausführungen nicht in der bloßen Analyse der Filme – bevor die Filme überhaupt erwähnt werden, verschafft Stiasny den Leserinnen und Lesern zunächst einen Überblick über die Filmentwicklung vor dem Hintergrund der jeweiligen Zeit und stellt Bezüge zu sozialen, politischen und kulturellen Fragen her.
Das Thema Krieg findet sich so erfreulicherweise nicht nur in dramatischen und niederschmetternden Bildern wieder, sondern etwa auch in der Rolle der Frauen, die zu dieser Zeit ihre Selbständigkeit entdeckten. Die detailliertere Auseinandersetzung mit den Filmen, Weihnachtsglocken (1914), Ikarus (1919) oder Welt ohne Krieg wird neben der reinen Analyse des Materials ergänzt durch Zensurunterlagen sowie original Filmberichterstattung. Viele Szenen sind als Abbildung in den Text integriert. Dies sowie der interessante und fachkundige Schreibstil machen das Buch sehr lesenswert für Film-, Medien-, und Kulturwissenschaftlerinnen und -wissenschaftler, Geschichts- und Filminteressierte sowie Studierende und interessierte Laien.
Bidlo, Oliver/Englert, Carina Jasmin/ Reichertz, Jo (Hrsg.) (2011). Securitainment. Medien als Akteure der inneren Sicherheit. Wiesbaden: VS Verlag. 266 S., 29,95 €
Authors: Merz Redaktion
Published: November 2024

Inwieweit agieren die (privaten) Medien im gesellschaftlichen Diskurs um Innere Sicherheit on air und off air eigenständig? Inwieweit können sie zu Recht als selbständige Akteure begriffen werden?
Die Herausgeber und die Herausgeberin des Buches beobachten, dass Fernsehen, Zeitung und Internet zusehends nicht mehr nur die Berichterstatter sind, sondern sich ihrerseits am Diskurs über die richtige (Sicherheits-) Politik beteiligen. Sie kommentieren Entscheidungen, sie liefern den Deutungsrahmen und setzen bestimmte Themen auf die Agenda. Sie werden aus wirtschaftlichen Gründen zu eigenständigen Akteuren, die die Politik der Inneren Sicherheit mitgestalten. Im aktuellen Buch Securitainment werden Medien in ihren unterschiedlichen Rollen als Akteure, Aktivisten und schließlich in ihrer gewandelten Rolle als ‚Wachhund‘ anstelle des Vermittlers genauer untersucht. Am Ende wird das Securitainment thematisiert. Der Inneren Sicherheit wird ein Unterhaltungswert verliehen. Die Fragen der Autoren wurden im Rahmen des DFG-Projektes Medien als Akteure aus soziologischer und kommunikationswissenschaftlicher Sicht erforscht. Die ‚Vierte Gewalt im Staat‘ hat stets eine besondere Rolle gegenüber der Legislative, der Judikativen und Exekutiven und deren Politik eingenommen.
Doch neu ist, dass die (privaten) Medien seit Beginn der 1990er Jahre vor allem Unternehmen sind, die geführt und vermarktet werden müssen. Sie sind damit eher dem Kunden als einer kritischen Öffentlichkeit verpflichtet. Printmedien haben mit sinkender Nachfrage zu kämpfen. Das Internet und ‚Bürgerreporter‘, die sich an der Nachrichtenproduktion beteiligen, haben die Situation grundlegend verändert. Zudem ist zu beobachten, dass die privaten Medien sich in Vertretung ihrer Kunden und Käufer in Diskurse einmischen und diese gestalten wollen. Das Buch setzt sich mit diesen Trends des steigenden ökonomischen Drucks, der härteren Konkurrenz und der Notwendigkeit der Kundenbindung auseinander, die zu politischen Aktionen nötigen. An Hand der Ergebnisse der empirischen Untersuchung in der Zeit zwischen 2009 und 2011 wurden das Maß der Mitgestaltung gesellschaftlicher Diskurse über die ‚richtige‘ (Sicherheits-) Politik und die tatsächliche Eigenständigkeit der Medien untersucht.
Neues Medium, neue Moral?
Authors: Klimmt Christoph , Weil Yvonne
Published: November 2024

Filesharing, insbesondere im Musikbereich, bedingt medienpädagogische Herausforderungen auch aufgrund der moralischen Dimension im Umgang mit Urheber- und Nutzungsrechten. Musik ist ständiger Begleiter von Jugendlichen und über das Internet via Filesharing relativ einfach kostenlos zu beziehen. Die Ergebnisse der hier vorgestellten Umfragestudie dokumentieren moralbezogene Ansichten von Jugendlichen zu dieser Thematik und zeigen medienpädagogische Ansatzpunkte auf, die auch für andere Gebiete des sozialen Handelns im Virtuellen gelten können.