bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Improvement with a Feedforward Control Strategy of Bidirectional DC-DC Converter for Battery Charging and Discharging
Authors: Han Jingang , Gu Xin , Yang Yi , Tang Tianhao
Published: October 2020

With the increasing importance of power accumulator batteries in electric vehicles, the accurate characteristics of power accumulator batteries have an important role. In order to evaluate the power accumulator battery, battery charging and discharging is indispensable. In this article, a H-bridge bidirectional DC-DC converter is presented which can charge and discharge the battery with different voltage levels and one of the merits of this topology is that a wide output voltage range can be easily achieved. In the control part, a proportional-integral (PI) control strategy is adopted to ensure a stable and reliable operation of the converter. Furthermore, compared with the PI control strategy, a duty ratio feedforward control is utilized to obtain the rapid current dynamic response. In this article, firstly, the system configuration for battery charging and discharging is introduced, then the operating principles and mathematical model of the DC-DC converter are analyzed and derived. Secondly, for bidirectional DC-DC converters, the PI control method and duty ratio feedforward control method are put forward and designed. Finally, the simulation model is established based on PSIM software and the experiment platform is also built in lab. The results of the simulation and experiment research show that the H-bridge bidirectional DC-DC converter can operate reliably and stably during the charging, discharging and power flow reverse modes. In addition, the dynamic response of the charging and discharging current can also be further improved by introducing the duty ratio feedforward control method.
An Efficient Hardware Architecture with Adjustable Precision and Extensible Range to Implement Sigmoid and Tanh Functions
Authors: Chen Hui , Jiang Lin , Yang Heping , Lu Zhonghai , Fu Yuxiang , Li Li , Yu Zongguang
Published: October 2020

The efficient and precise hardware implementations of tanh and sigmoid functions play an important role in various neural network algorithms. Different applications have different requirements for accuracy. However, it is difficult for traditional methods to achieve adjustable precision. Therefore, we propose an efficient-hardware, adjustable-precision and high-speed architecture to implement them for the first time. Firstly, we present two methods to implement sigmoid and tanh functions. One is based on the rotation mode of hyperbolic CORDIC and the vector mode of linear CORDIC (called RHC-VLC), another is based on the carry-save method and the vector mode of linear CORDIC (called CSM-VLC). We validate the two methods by MATLAB and RTL implementations. Synthesized under the TSMC 40 nm CMOS technology, we find that a special case AR∣VR(3,0), based on RHC-VLC method, has the area of 4290.98 μm2 and the power of 1.69 mW at the frequency of 1.5 GHz. However, under the same frequency, AR∣VC(3) (a special case based on CSM-VLC method) costs 3196.36 μm2 area and 1.38 mW power. They are both superior to existing methods for implementing such an architecture with adjustable precision.
Development of a Statistical Workflow for Screening Protein Extracts Based on Their Nutritional Composition and Digestibility: Application to Elderly
Authors: Duval Angéline , Sayd Thierry , Aubry Laurent , Ferreira Claude De Oliviera , Ferraro Vincenza , Sante-Lhoutellier Véronique
Published: October 2020

The objective of the study is to develop a workflow to screen protein extracts and identify their nutritional potential as high quality nutritional culinary aids for recipes for the elderly. Twenty-seven protein extracts of animal, vegetable, and dairy origin were characterized. We studied their fate by monitoring static in vitro digestion, mimicking the physiological digestion conditions of the elderly. At the end of the gastric and intestinal phase, global measurements of digestibility and antioxidant bioactivities were performed. The statistical analysis workflow developed allowed: (i) synthesizing the compositional and nutritional information of each protein extract by creating latent variables, and (ii) comparing them. The links between variables and similarities between protein extracts were visualized using a heat map. A hierarchical cluster analysis allowed reducing the 48 quantitative variables into 15 qualitative latent variables (clusters). The application of the k-means method on each cluster enable to classify the protein extracts by level. This defined level was used as categorical value. Multiple correspondence analysis revealed groups of protein extracts with varied patterns. This workflow allowed the comparison/hierarchization between protein extracts and the creation of a tool to select the most interesting ones on the basis of their nutritional quality.
Detection of Bacterial Pathogens and Antibiotic Residues in Chicken Meat: A Review
Authors: Kumar Harsh , Bhardwaj Kanchan , Kaur Talwinder , Nepovimova Eugenie , Kuča Kamil , Kumar Vinod , Bhatia Shashi Kant , Dhanjal Daljeet Singh , Chopra Chirag , Singh Reena , Guleria Shivani , Bhalla Tek Chand , Verma Rachna , Kumar Dinesh
Published: October 2020

Detection of pathogenic microbes as well as antibiotic residues in food animals, especially in chicken, has become a matter of food security worldwide. The association of various pathogenic bacteria in different diseases and selective pressure induced by accumulated antibiotic residue to develop antibiotic resistance is also emerging as the threat to human health. These challenges have made the containment of pathogenic bacteria and early detection of antibiotic residue highly crucial for robust and precise detection. However, the traditional culture-based approaches are well-comprehended for identifying microbes. Nevertheless, because they are inadequate, time-consuming and laborious, these conventional methods are not predominantly used. Therefore, it has become essential to explore alternatives for the easy and robust detection of pathogenic microbes and antibiotic residue in the food source. Presently, different monitoring, as well as detection techniques like PCR-based, assay (nucleic acid)-based, enzyme-linked immunosorbent assays (ELISA)-based, aptamer-based, biosensor-based, matrix-assisted laser desorption/ionization-time of flight mass spectrometry-based and electronic nose-based methods, have been developed for detecting the presence of bacterial contaminants and antibiotic residues. The current review intends to summarize the different techniques and underline the potential of every method used for the detection of bacterial pathogens and antibiotic residue in chicken meat.
Accurate Road Marking Detection from Noisy Point Clouds Acquired by Low-Cost Mobile LiDAR Systems
Authors: Yang Ronghao , Li Qitao , Tan Junxiang , Li Shaoda , Chen Xinyu
Published: October 2020

Road markings that provide instructions for unmanned driving are important elements in high-precision maps. In road information collection technology, multi-beam mobile LiDAR scanning (MLS) is currently adopted instead of traditional mono-beam LiDAR scanning because of the advantages of low cost and multiple fields of view for multi-beam laser scanners; however, the intensity information scanned by multi-beam systems is noisy and current methods designed for road marking detection from mono-beam point clouds are of low accuracy. This paper presents an accurate algorithm for detecting road markings from noisy point clouds, where most nonroad points are removed and the remaining points are organized into a set of consecutive pseudo-scan lines for parallel and/or online processing. The road surface is precisely extracted by a moving fitting window filter from each pseudo-scan line, and a marker edge detector combining an intensity gradient with an intensity statistics histogram is presented for road marking detection. Quantitative results indicate that the proposed method achieves average recall, precision, and Matthews correlation coefficient (MCC) levels of 90%, 95%, and 92%, respectively, showing excellent performance for road marking detection from multi-beam scanning point clouds.
Evolution and Optimization of Urban Network Spatial Structure: A Case Study of Financial Enterprise Network in Yangtze River Delta, China
Authors: Zhang Yizhen , Wang Tao , Supriyadi Agus , Zhang Kun , Tang Zhi
Published: October 2020

The urban network is an important method of spatial optimization, and measuring the development level of the urban network is a prerequisite for spatial optimization. Combining geographic information system (GIS) spatial analysis, social network analysis, and multidimensional scaling models, we explored the evolution of the urban network spatial structure in the Yangtze River Delta from 1990 to 2017 and proposed corresponding optimization measures. The results showed that the urban network spatial structure of the Yangtze River Delta has evolved from a single-center cluster with Shanghai as its core to a multi-center network with Shanghai as its core and Nanjing, Hangzhou, and Hefei as secondary cores. The density of the urban network has gradually expanded, but the strength of the connection between edge cities such as Chizhou, Suqian, and Quzhou and the core cities needs to be further improved. We found that the evolution of the urban network spatial structure has been driven by preferential attachment, path dependence, and differences in economic and industrial development. Finally, we propose optimizing the urban network spatial structure by strengthening the driving ability of the core cities, clarifying urban functions and development directions, and establishing a unified coordination mechanism. This paper enriches and deepens our understanding of the characteristics of the city network in the Yangtze River Delta, and provides a reference for the optimization of the urban network spatial structure.
Clinic Utilization and Characteristics of Patients Accessing a Prostate Cancer Supportive Care Program’s Sexual Rehabilitation Clinic
Authors: Wong Julie , Witherspoon Luke , Wu Eugenia , Sheikholeslami Sara , Liao Wen , Yuen Wallace , Bentley Jenna , Zarowski Christine , Sundar Monita , Elliott Stacy , Higano Celestia S. , Flannigan Ryan
Published: October 2020

Prostate cancer (PC) treatment leads to impairment of sexual function. The Prostate Cancer Supportive Care (PCSC) Program’s Sexual Rehabilitation clinic (SRC) assists patients and their partners with sexual recovery using a biopsychosocial approach to rehabilitation. This study characterizes patients seen in the SRC between July 2013–1 July 2019. Data was retrospectively abstracted from clinic records. In total, 965 patients were seen over 3391 appointments during the study period. Median age (standard deviation (SD)) was 66 years (SD = 7.1), 82.0% were partnered, yet 81.7% attended appointments alone. 88.0% were treated with surgery, 5.1% with brachytherapy, 3.7% with external beam radiation (EBRT), 1.8% with combined brachytherapy and EBRT, and 1.4% with androgen deprivation therapy. In total, 708 patients (73.4%) attended ≥1 follow-up appointment. Median time (SD) between end of prostate cancer treatment to first SRC appointment was 270 days (range 0–7766). The mean (SD) self-reported overall sexual satisfaction (extracted from International Index of Erectile Function-5 (IIEF-5)) significantly increased both with erectile aids (1.69 (SD = 1.52) to 2.26 (SD = 1.66), p < 0.001, n = 148) and without erectile aids (1.71 (SD = 1.44) to 2.35 (SD = 1.57), p < 0.001, n = 235). This study provides guidance for further investigation to refine treatment, wait-times, support, and/or resource offerings in this type of program.
Ginsenoside Rb3 Inhibits Pro-Inflammatory Cytokines via MAPK/AKT/NF-κB Pathways and Attenuates Rat Alveolar Bone Resorption in Response to Porphyromonas gingivalis LPS
Authors: Sun Minmin , Ji Yaoting , Li Zhen , Chen Rourong , Zhou Shuhui , Liu Chang , Du Minquan
Published: October 2020

Conventional treatments for chronic periodontitis are less effective in controlling inflammation and often relapse. Therefore, it is necessary to explore an immunomodulatory medication as an adjuvant. Ginsenoside Rb3 (Rb3), one of the most abundant active components of ginseng, has been found to possess anti-inflammatory and immunomodulatory properties. Here, we detected the anti-inflammatory effect of Rb3 on Porphyromonas gingivalis LPS-stimulated human periodontal ligament cells and experimental periodontitis rats for the first time. We found that the expression of pro-inflammatory mediators, including IL-1β, IL-6 and IL-8, upregulated by lipopolysaccharide (LPS) stimulation was remarkably downregulated by Rb3 treatment in a dose-dependent manner at both transcriptional and translational levels. Network pharmacological analysis of Rb3 showed that the mitogen-activated protein kinase (MAPK) signaling pathway had the highest richness and that p38, JNK, and ERK molecules were potential targets of Rb3 in humans. Western blot analysis revealed that Rb3 significantly suppressed the phosphorylation of p38 MAPK and p65 NF-κB, as well as decreased the expression of total AKT. In experimental periodontitis rat models, reductions in alveolar bone resorption and osteoclast generation were observed in the Rb3 treatment group. Thus, we can conclude that Rb3 ameliorated Porphyromonas gingivalis LPS-induced inflammation by inhibiting the MAPK/AKT/NF-κB signaling pathways and attenuated alveolar bone resorption in experimental periodontitis rats.
How Do Aromatic Nitro Compounds React with Nucleophiles? Theoretical Description Using Aromaticity, Nucleophilicity and Electrophilicity Indices
Authors: Błaziak Kacper , Danikiewicz Witold , Mąkosza Mieczysław
Published: October 2020

In this study, we present a complete description of the addition of a model nucleophile to the nitroaromatic ring in positions occupied either by hydrogen (the first step of the SNAr-H reaction) or a leaving group (SNAr-X reaction) using theoretical parameters including aromaticity (HOMA), electrophilicity and nucleophilicity indices. It was shown both experimentally and by our calculations, including kinetic isotope effect modeling, that the addition of a nucleophile to the electron-deficient aromatic ring is the rate limiting step of both SNAr-X and SNAr-H reactions when the fast transformation of σH-adduct into the products is possible due to the specific reaction conditions, so this is the most important step of the entire reaction. The results described in this paper are helpful for better understanding of the subtle factors controlling the reaction direction and rate.
Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics
Authors: Pinson Anna O. , Pouncey Dakota L. , Schleiff Mary A. , Fantegrossi William E. , Prather Paul L. , Radominska-Pandya Anna , Boysen Gunnar , Miller Grover P.
Published: October 2020

In 2020, nearly one-third of new drugs on the global market were synthetic cannabinoids including the drug of abuse N-(1-adamantyl)-1-(5-pentyl)-1H-indazole-3-carboxamide (5F-APINACA, 5F-AKB48). Knowledge of 5F-APINACA metabolism provides a critical mechanistic basis to interpret and predict abuser outcomes. Prior qualitative studies identified which metabolic processes occur but not the order and extent of them and often relied on problematic “semi-quantitative” mass spectroscopic (MS) approaches. We capitalized on 5F-APINACA absorbance for quantitation while leveraging MS to characterize metabolite structures for measuring 5F-APINACA steady-state kinetics. We demonstrated the reliability of absorbance and not MS for inferring metabolite levels. Human liver microsomal reactions yielded eight metabolites by MS but only five by absorbance. Subsequent kinetic studies on primary and secondary metabolites revealed highly efficient mono- and dihydroxylation of the adamantyl group and much less efficient oxidative defluorination at the N-pentyl terminus. Based on regiospecificity and kinetics, we constructed pathways for competing and intersecting steps in 5F-APINACA metabolism. Overall efficiency for adamantyl oxidation was 17-fold higher than that for oxidative defluorination, showing significant bias in metabolic flux and subsequent metabolite profile compositions. Lastly, our analytical approach provides a powerful new strategy to more accurately assess metabolic kinetics for other understudied synthetic cannabinoids possessing the indazole chromophore.
Discovery of Potential Chemical Probe as Inhibitors of CXCL12 Using Ligand-Based Virtual Screening and Molecular Dynamic Simulation
Authors: Haider Sajjad , Barakat Assem , Ul-Haq Zaheer
Published: October 2020

CXCL12 are small pro-inflammatory chemo-attractant cytokines that bind to a specific receptor CXCR4 with a role in angiogenesis, tumor progression, metastasis, and cell survival. Globally, cancer metastasis is a major cause of morbidity and mortality. In this study, we targeted CXCL12 rather than the chemokine receptor (CXCR4) because most of the drugs failed in clinical trials due to unmanageable toxicities. Until now, no FDA approved medication has been available against CXCL12. Therefore, we aimed to find new inhibitors for CXCL12 through virtual screening followed by molecular dynamics simulation. For virtual screening, active compounds against CXCL12 were taken as potent inhibitors and utilized in the generation of a pharmacophore model, followed by validation against different datasets. Ligand based virtual screening was performed on the ChEMBL and in-house databases, which resulted in successive elimination through the steps of pharmacophore-based and score-based screenings, and finally, sixteen compounds of various interactions with significant crucial amino acid residues were selected as virtual hits. Furthermore, the binding mode of these compounds were refined through molecular dynamic simulations. Moreover, the stability of protein complexes, Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), and radius of gyration were analyzed, which led to the identification of three potent inhibitors of CXCL12 that may be pursued in the drug discovery process against cancer metastasis.
The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects
Authors: Ryskalin Larisa , Biagioni Francesca , Busceti Carla L. , Lazzeri Gloria , Frati Alessandro , Fornai Francesco
Published: October 2020

The present review focuses on the multi-faceted effects of curcumin on the neurobiology glioblastoma multiforme (GBM), with a special emphasis on autophagy (ATG)-dependent molecular pathways activated by such a natural polyphenol. This is consistent with the effects of curcumin in a variety of experimental models of neurodegeneration, where the molecular events partially overlap with GBM. In fact, curcumin broadly affects various signaling pathways, which are similarly affected in cell degeneration and cell differentiation. The antitumoral effects of curcumin include growth inhibition, cell cycle arrest, anti-migration and anti-invasion, as well as chemo- and radio-sensitizing activity. Remarkably, most of these effects rely on mammalian target of rapamycin (mTOR)-dependent ATG induction. In addition, curcumin targets undifferentiated and highly tumorigenic GBM cancer stem cells (GSCs). When rescuing ATG with curcumin, the tumorigenic feature of GSCs is suppressed, thus counteracting GBM establishment and growth. It is noteworthy that targeting GSCs may also help overcome therapeutic resistance and reduce tumor relapse, which may lead to a significant improvement of GBM prognosis. The present review focuses on the multi-faceted effects of curcumin on GBM neurobiology, which represents an extension to its neuroprotective efficacy.
Effect of Short Blade Circumferential Position Arrangement on Gas-Liquid Two-Phase Flow Performance of Centrifugal Pump
Authors: Wang Biaobiao , Zhang Haoyang , Deng Fanjie , Wang Chenguang , Si Qiaorui
Published: October 2020

In order to study the internal flow characteristics of centrifugal pumps with a split impeller under gas-liquid mixed transportation conditions, this paper conducted a steady calculation of the flow field in the centrifugal pump under the conditions of different inlet gas volume fractions based on the Eulerian-Eulerian heterogeneous flow model, using air and water as the working media and the Schiller Nauman model for the interphase resistance. This paper takes a low specific speed centrifugal pump as the research object, through the controlling variables, using the same pump body structure and pump body geometric parameters and setting three different arrangements of long and short blades (each plan uses the same long and short blades) to explore the influence of the short blade arrangement on the low specific speed centrifugal pump performance under a gas-liquid two-phase flow. The research results show that, under pure water conditions, the reasonable arrangement of the short blade circumferential position can eliminate the hump of the centrifugal pump under low-flow conditions, can make the flow velocity in the impeller more uniform, and can optimize the performance of the pump. Under the design conditions and the gas-liquid two-phase inflow conditions, when the circumferential position of the short blades is close to the suction surface of the long blades, some of the bubbles on the suction surface of the long blade can be broken under the work of the pressure surface of the short blade and flow out of the impeller with the liquid, which improves the flow state of the flow field in the impeller.
Body Composition versus BMI as Measures of Success in a Clinical Pediatric Weight Management Program
Authors: Stackpole Kristin , Khoury Philip , Siegel Robert , Gier Amanda
Published: October 2020

The high rates and long-term medical consequences of childhood obesity make it a public health crisis requiring effective diagnosis, treatment, and prevention. Although BMI is an adequate screening tool for obesity, monitoring BMI change is not always the best measure of success in treating patients in a pediatric weight management program. Our retrospective study evaluated the proportion of patients that achieved favorable changes in body composition by bioelectrical impedance analysis in the absence of improvements in BMI, BMI percentile, or percent of the 95th percentile for BMI. It was found that 30% of patients whose BMI increased by 1.0 kg/m2 or more, 31.6% of patients with stable or increasing BMI percentiles, and 28% with stable or increasing percent of the 95th percentile for BMI demonstrated an improvement in body composition (skeletal muscle mass and body fat percentage). Body composition is an important measure of success for a subset of patients who otherwise may believe that their efforts in lifestyle change have not been effective. Our results suggest that including body fat percentage as a measure of success in evaluating the progress of patients participating in a pediatric weight management program is appropriate and may more accurately track success than change in BMI or BMI percentile alone.
Rabies as a Public Health Concern in India—A Historical Perspective
Authors: Radhakrishnan Sreejith , Vanak Abi Tamim , Nouvellet Pierre , Donnelly Christl A.
Published: October 2020

India bears the highest burden of global dog-mediated human rabies deaths. Despite this, rabies is not notifiable in India and continues to be underprioritised in public health discussions. This review examines the historical treatment of rabies in British India, a disease which has received relatively less attention in the literature on Indian medical history. Human and animal rabies was widespread in British India, and treatment of bite victims imposed a major financial burden on the colonial Government of India. It subsequently became a driver of Pasteurism in India and globally and a key component of British colonial scientific enterprise. Efforts to combat rabies led to the establishment of a wide network of research institutes in India and important breakthroughs in development of rabies vaccines. As a result of these efforts, rabies no longer posed a significant threat to the British, and it declined in administrative and public health priorities in India towards the end of colonial rule—a decline that has yet to be reversed in modern-day India. The review also highlights features of the administrative, scientific and societal approaches to dealing with this disease in British India that persist to this day.
A Polypeptide of Tumor-Associated Antigen L6 with Intrinsic Adjuvant Activity Enhances Antitumor Immunity
Authors: Sher Yuh-Pyng , Chai Kit Man , Chen Wen-Ching , Shen Kuan-Yin , Chen I-Hua , Lee Ming-Hui , Chiu Fang-Feng , Liu Shih-Jen
Published: October 2020

Peptide vaccines are safe, and aim to elicit and expand tumor-specific immunity so as to eradicate tumors. However, achieving strong and long-lasting anti-tumor immunity with peptide vaccines for the antigen-specific treatment of cancer is challenging, in part because their efficacy depends on strong adjuvants or immunomodulators. We approached this problem by conjugating an epitope-based cancer vaccine with a lipidated sequence (an immunomodulator) to elicit a strong immune response. Lipidated and non-lipidated polyepitope proteins were generated that contained the universal T helper cell epitope (pan-DR), B cell epitopes, and the extended loop sequence of extracellular domain 2 of tumor-associated antigen L6 (TAL6). We show that the lipidated polyepitope cancer vaccine can activate bone marrow-derived dendritic cells, and trigger effective antigen-specific antibody and T helper cell responses, more effectively than the non-lipidated vaccine. Moreover, potent T cell immune responses were elicited in mice inoculated with the lipidated polyepitope cancer vaccine, providing protective antitumor immunity in mice bearing TAL6 tumors. Our study demonstrates that a lipidated polyepitope cancer vaccine could be employed to generate potent anti-tumor immune responses, including humoral and cellular immunity, which could be beneficial in the treatment of TAL6+ cancer.
Specification of Synchronous Network Flooding in Temporal Logic
Authors: Bani Abdelrahman Ra’ed , Alshorman Rafat , Hussak Walter , Trehan Amitabh
Published: October 2020

In distributed network algorithms, network flooding algorithm is considered one of the simplest and most fundamental algorithms. This research specifies the basic synchronous memory-less network flooding algorithm where nodes on the network don’t have memory, for any fixed size of network, in Linear Temporal Logic. The specification can be customized to any single network topology or class of topologies. A specification of the termination problem is formulated and used to compare different topologies for earlier termination. This research gives a worked example of one topology resulting in earlier termination than another, for which we perform a formal verification using the model checker NuSMV
Design and Implementation of Crypt Analysis of Cloud Data Intrusion Management System
Authors: Elangovan Dinesh , Muthiya Ramesh
Published: October 2020

Cloud computing is the method of employing a set-up of isolated servers to be hosted on the web to accumulate and supervise information instead of an area server or a private laptop. Storage of data in cloud sometimes creates security issues in the data stored so, security in provided for the stored cloud data. In order to provide secured cloud data transaction, our proposed method initially verifies the authentication of the user followed by splitting the information of the user using pattern-matching technique. The blowfish computation is used to encrypt the alienated data. After encryption, resorting to the selection of the optimal position of a data center by means of the cross grey wolf optimization and firefly technique is done. Finally, the encrypted data are stored at an optimal location in the cloud. Then the data split column wise and separated at an optimal location in the cloud, this method is highly secured since the user cannot retrieve the file without authentication verification
Microfistulas Causing Diverse Regional Ischemia: Consecutive Inferior and Lateral ST-Elevation Myocardial Infarction
Authors: Çınar Tufan , Karabağ Yavuz , Rencuzogullari İbrahim , Cağdaş Metin
Published: October 2020

Coronary artery fistulas (CAFs) are described as abnormal communications between a coronary artery and cardiac chambers, or other vascular structures. The two types of CAFs are defined as type I (singular fistula) and type II (microfistulas). Even though various electrocardiographic changes have been previously described in CAF patients, coronary-artery microfistulas causing ST-segment elevation in diverse locations have not been reported. We describe a case report of an adult patient who presented with acute inferior myocardial infarction due to coronary-artery microfistulas. During the hospital stay, the patient re-experienced chest pain, and control electrocardiography revealed ST-segment elevation in the I and AVL leads along with reciprocal ST-segment depression in the inferior precordial leads. Although CAFs are clinically rare, they can have important clinical consequences. Microfistulas should be kept in mind as a cause of ST elevation myocardial infarction in some patients.
In Honor of Dr. Abdul Hussein Taba: Iranian Physician and Former Director of the Eastern Mediterranean Region of the World Health Organization
Authors: Mounesan Leila , Mostafavi Ehsan
Published: October 2020

The honorable Abdul Hussein Tabatabaei was born in 1911 in Iran and received his medical education in the United Kingdom. Famously known as Dr. A.H. Taba, he was a well-respected man for his significant impact on the improvement of the national and global healthcare services and support for social justice. Before joining the World Health Organization (WHO), he was twice elected to the Iranian national assembly and served as the under-secretary of health services in Iran. Later, he joined the WHO and was elected as the Director of the Eastern Mediterranean Region (EMRO) in Alexandria in 1957 – a position he maintained for 25 years. During his tenure as the Regional Director, he rendered valuable assistance to the development and expansion of major health issues such as development and expansion of the health workforce, improvement of the national health services and controlling of various communicable diseases in the member countries and across the WHO regional offices.
ROLE OF PATHOLOGICAL NEW FORMATIONS AND THEIR AGENTS IN THE FUNCTIONING OF NATURAL ECOSYSTEMS OF FOREST PARK ZONES
Authors: Kazbanova Irina
Published: October 2020

In recent years, there has been great interest in pathogenic growths in plants and their pathogens. This is explained by the possibilities of their use in various environmental spheres and covers biological aspects of natural and artificial ecosystems in normal and disturbed state, as well as the assessment and forecasting of natural cycles of biologically active substances, the ability of ecosystems to self-purify, and an assessment of the positive human impact on nature. That is why, it is extremely important (for the preservation and development of the normal functioning of natural ecosystems) to find out the real significance of natural factors and development of gall formation processes in natural ecosystems, as well as the actual scale of anthropogenic impact in them. This is especially important when disturbances have reached high levels and are critical in the natural environment in forest park zones. One of the important parts of the problem is assessment of predicting the natural environment in forest park zones. Therefore, it becomes necessary to consider the relationship between tree plantations in forest park zones and pathogens of pathological neoplasms. It is also necessary to find out what there is a relationship between tree plantations and pathogens of pathological growths.
MODERN DYNAMICS OF FOREST USE IN THE BOREAL FORESTS OF RUSSIA (FOR EXAMPLE OF THE ARKHANGELSK REGION)
Authors: Ilintsev Aleksey , Shamont'ev Ivan , Tretyakov Sergey
Published: October 2020

The article examines the dynamics of forest management in the Arkhangelsk region for the period from 2008 to 2020. Over the past three years, about 44 million m3 of marketable timber has been cut (57.6% of the permissible harvest). The withdrawal of marketable timber (within the allowable cut) increased by almost 1.5 times (from 10.24 to 14.86 million m3). The maximum volume of harvested wood falls on 2018 and 2020, respectively. The share of soft-leaved wood cut down during the period under review increased from 19.1% to 31.1%. This increase is due to the transport accessibility of secondary deciduous plantations located in close proximity to logging roads. The average share of marketable timber harvested by non-clear felling was 14.4%, the maximum volume of timber harvested by these fellings was recorded in 2020 - 2.6 million m3 or 17.4%. The total area involved in economic activities increased by 38.5%, from 100.8 thousand hectares to 138.9 thousand hectares. On average, 22.6% was allotted for partial cutting, and 77.4% for clear cutting. Spatial analysis of partial cuttings in the total volume of timber harvesting showed a very low percentage (up to 10%) in 14 forestries. This is due to the logging of the last century, the structure of the forest fund, the presence of wet and swampy areas, the lack of road infrastructure, etc. The distribution of forestries by the intensity of forest use showed that a high intensity of harvesting of marketable timber (over 500.1 thousand m3) is observed in 13 forest districts, mainly concentrated in the south of the Arkhangelsk region. The dynamics of the forest fund testifies that modern forest management has made adjustments to the distribution of the areas of forest plantations in the context of age groups and household sections. For example, the area of coniferous forests decreased by 649.2 thousand hectares (3.8%), while the area of soft-leaved forests increased by 471.95 thousand hectares or 9.1%. Past and modern forest management is reflected in the age structure of forests. A very small percentage of ripening stands in the future will not make it possible to compensate for the felled ripe and overmature stands at their expense. It is possible to level the age structure of the forest fund and form a so-called continuous forest taking into account the current trends in forest management, when on average about 60% of periodic yield is cut down
Modeling and Optimization of the Activity of a Transport Enterprise
Authors: Жолудева В.В. , Уткин Е.В.
Published: October 2020

Рассматривается деятельность автотранспортного предприятия ООО ЦЗК «Логистик». Проведено математическое моделирование работы объекта исследования с использованием систем массового обслуживания. Для оценки оптимальности работы ООО ЦЗК «Логистик» были построены регрессионные модели, связывающие результативные показатели эффективности функционирования автосервиса с влияющими на них производственными факторами. Полученные результаты позволяют сделать вывод об эффективной оптимальной деятельности исследуемого предприятия.

The activity of the transport enterprise OOO CZK "Logistic" is considered. Mathematic simulation of the research object operation using service system has been carried out. To assess the optimality of the work of OOO CZK "Logistic" regression models were built linking the effective performance indicators of the operation of the car-care center with the production factors affecting them. The obtained results make it possible to conclude about effective optimal activity of the enterprise under investigation.
Control of all the transitions between ground state manifolds of nitrogen vacancy centers in diamonds by applying external magnetic driving fields
Authors: Yamaguchi Tatsuma , Matsuzaki Yuichiro , Saijo Soya , Watanabe Hideyuki , Mizuochi Norikazu , Ishi-Hayase Junko
Published: October 2020

We demonstrate control of all the three transitions among the ground state sublevels of NV centers by applying magnetic driving fields. To address the states of a specific NV axis among the four axes, we apply a magnetic field orthogonal to the NV axis. We control two transitions by microwave pulses and the remaining transition by radio frequency (RF) pulses. In particular, we investigate the dependence of Rabi oscillations on the frequency and intensity of the RF pulses. In addition, we perform a π pulse by the RF pulses and measured the coherence time between the ground state sublevels. Our results pave the way for control of NV centers for the realization of quantum information processing and quantum sensing.
A compact and low-driving-voltage silicon electro-absorption modulator utilizing a Schottky diode operating up to 13.2 GHz in C-band
Authors: Jeong Uiseok , Kim Kwangwoong , Lee Kyungwoon , Park Jung Ho
Published: October 2020

This paper demonstrates a 1 Vpp low-driving-voltage silicon electro-absorption modulator (EAM) utilizing a Schottky diode. Optical modulation using a Schottky diode was achieved through the intensity change of the guiding light due to free-carrier absorption in the semiconductor to change its absorption coefficient, not through conventional interference effects. The proposed EAM consists of a lateral metal–semiconductor junction that helps maximize free-carrier injection and extraction through a Schottky contact on rib waveguide. In order to achieve high-speed operation, traveling-wave type electrodes were designed. The fabricated EAM demonstrates a broad operational wavelength range of 50 nm for C-band with a uniform extinction ratio (ER) of 3.9 dB, even for a compact modulation length of 25 μm with a driving voltage of 1 Vpp. Also, the traveling-wave type electrodes enabled the modulator to operate at up to 26 GHz with 13.2 GHz of 3 dB electro-optic bandwidth experimentally.
Efektifitas Ekuitas Merek Berbasis Pelanggan Pada Pengguna e-Ritel
Authors: Dewi Intan Permata
Published: October 2020

Abstract - Customer based brand equity has recently emerged in both academic literature and practitioner discussions. The number of e-commerce that began to be established into consideration for every consumer to determine where they will shop online. In order to reduce the potential for customers to choose other e-commerce, companies need to increase customer-based brand equity. This research was conducted at one e retail in Indonesia through an online survey. Measurement of customer based brand equity uses dimensions 1) Emotional connection, 2) Online Experience, 3) Responsive Service Nature, 4) Trust, and 5) Fulfillment. The method used was an explanatory survey with 200 Tabachnick and Fidell sample techniques. The data analysis technique used is structural equation modeling (SEM) with the AMOS 22.0 for Windows program. The findings of this study indicate that the dimension of responsive service nature as a whole has the highest value, while for the dimension that has the lowest value is trust.

 

Abstrak - Ekuitas merek berbasis pelanggan baru-baru ini muncul baik dalam literatur akademik dan diskusi praktisi. Jumlah e-commerce yang terus bertambah menjadi pertimbangan bagi setiap konsumen untuk menentukan di mana mereka akan berbelanja online. Untuk mengurangi potensi pelanggan memilih e-commerce lain, perusahaan perlu meningkatkan ekuitas merek berbasis pelanggan. Penelitian ini dilakukan di salah satu e retail di Indonesia melalui survei online. Pengukuran ekuitas merek berbasis pelanggan menggunakan dimensi 1) Emotional connection, 2) Online Experience, 3) Responsive Service Nature, 4) Trust, and 5) Fulfillment. Metode yang digunakan adalah explanatory survei dengan 200 responden dan teknik perhitungan sampel dari Tabachnick dan Fidell. Teknik analisis data yang digunakan adalah pemodelan persamaan struktural (SEM) dengan program AMOS 22.0 for Windows. Temuan penelitian ini menunjukkan bahwa dimensi sifat Responsive Service Nature secara keseluruhan memiliki nilai tertinggi, sedangkan untuk dimensi yang memiliki nilai terendah adalah Trust.
Pengaruh Struktur Modal, Profitabilitas, dan Risiko Perusahaan Terhadap Nilai Perusahaan Pada Sub Sektor Wholesale Yang Terdaftar Di Bursa Efek Indonesia Periode 2014-2018
Authors: Handayani Sri Rezeki , Jamaluddin Jamaluddin , Palit Trifena Claudia , Sipahutar Ine Anggitta
Published: October 2020

Abstract- This study aims to discuss the effect of Capital Structure, Profitability, Company Risk on the value of the Wholesale sub-sector companies listed on the Indonesia Stock Exchange in the 2014-2018 period. Either partially or simultaneously related. The total population of this study was 44 companies and only 13 companies met the criteria to be sampled. The sample research method used was purposive sampling. Multiple linier regression analysis that includes: Normality Test, Multicollinearity Test, Heteroscedasticity, Autokoleration Test, Multiple Linear Regression Hypothesis Test, and Hypothesis Test using the coefficient of Determination, F Test and t Test.The results showed that the capital structure is partially determined and significant to of Company’s Value, Profitability partially determined and significant to of the Company’s Value, and Company Risk partially determined and significant to of the Company’s Value. The Capital Structure, Profitability and Risk of the Company determines and is significant to the Company’s Value with an Adjusted R value of 0,337 or 33,7%.

  

Abstrak- Penelitian ini bertujuan untuk menguji Pengaruh Struktur modal,Profitabilitas,Risiko Perusahaan terhadap Nilai Perusahaan sub Sektor Wholesale yang terdaftar di Bursa Efek Indonesia periode 2014-2018. Baik berhubungan secara parsial atau simultan. Jumlah populasi penelitian ini sebanyak 44 perusahaan dan  hanya 13 perusahaan yang memenuhi kriteria untuk dijadikan sampel. Metode penelitian sampel yang digunakan adalah sampling purposive. Analisis regresi linier berganda yaitu meliputi: Uji Normalitas, Uji Multikolonieritas, Uji Heteroskedastisitas,Uji Autokolerasi, Uji Hipotesis Regresi Linier Berganda, dan Uji Hipotesis menggunakan koefisien Determinasi, Uji F dan Uji t. hasil penelitian menunjukkan secara Parsial struktur modal berpengaruh dan signifikan terhadap Nilai Perusahaan, Profitabilitas berpengaruh dan signifikan terhadap Nilai Perusahaan, dan Risiko Perusahaan berpengaruh dan signifikan terhadap Nilai Perusahaan. Secara Simultan Struktur Modal, Profitabilitas dan Risiko Perusahaan berpengaruh dan signifikan terhadap Nilai Perusahaan dengan nilai Adjusted R sebesar 0,337 atau 33,7%.
PENGARUH RELATIONSHIP MARKETING TERHADAP CUSTOMER RETENTION PADA STUDIO MUSIK 58 SURAKARTA
Authors: Handaruwati Indah , Wibowo Obed Christian
Published: October 2020

Abstract– This study aims to analyze the effect of Relationship Marketing on Customer Retention in 58 Surakarta music studios. In connection with this problem, the following hypothesis is proposed, H1: Allegedly there is the influence of Customer Experience on Customer Retention, H2: Allegedly there is an influence of Communication on Customer Retention, H3: Allegedly there is the influence of Conflict Handling on Customer Retention, H4: Allegedly there is the influence of Customer Experience, Communication, Conflict Handling simultaneously for Customer Retention. The population in this study were all customers of Surakarta 58 studio music studio rental services, sampling using purposive sampling and convenience sampling techniques. The samples used in this study were 80 consumers. Data collection using a questionnaire. Data analysis was performed with multiple linear regression analysis test with SPSS 16.00 software. The results showed that Customer Experience had no significant effect on Customer Retention with a significance value of 0.142, Communication had a significant effect on Customer Retention with a significance value of 0.045, Conflict Handling had a significant effect on Customer Retention with a significant value of 0,000, Customer Experience, Communication and Conflict Handling had a significant effect Simultaneous to Customer Retention of 27,691.

 

Abstrak– Penelitian ini bertujuan untuk menganalisis pengaruh Relationship Marketing terhadap Customer Retention pada studio musik 58 Surakarta. Sehubungan dengan masalah tersebut, diajukan hipotesis sebagai berikut, H1 : Diduga ada pengaruh Customer Experience terhadap Customer Retention, H2: Diduga ada pengaruh Communication terhadap Customer Retention, H3: Diduga  ada pengaruh Conflict Handling  terhadap Customer Retention, H4: Diduga ada pengaruh Customer Experience, Communication, Conflict Handling secara simultan terhadap Customer Retention. Populasi dalam penelitian ini adalah semua pelanggan pengguna jasa sewa studio musik 58 Surakarta, pengambilan sampel menggunakan teknik purposive sampling dan convenience sampling.Sampel yang digunakan dalam penelitian ini sebanyak 80 responden.Pengumpulan data menggunakan kuesioner.Analisis data dilakukan dengan uji analisis regresi linear berganda dengan software SPSS 16.00. Hasil penelitian menunjukan bahwa Customer Experience tidak berpengaruh secara signifikan terhadap Customer Retention dengan nilai signifikansi 0.142, Communication berpengaruh signifikan terhadap Customer Retention dengan nilai signifikansi 0.045, Conflict Handling berpengaruh signifikan terhadap Customer Retention dengan nilai signifikan 0.000, Customer Experience, Communication dan Conflict Handling berpengaruh secara simultan terhadap Customer Retention sebesar 27.691.
CORRELATION OF NEUTROPHILLYMPHOCYTE RATIO WITH GLYCOSYLATED HB IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.
Authors: Kumar V Sandeep , N. Aishwarya Ganga S , S. Anand A.
Published: October 2020

Introduction: Neutrophilic leukocytosis is directly associated with the pathogenesis of atherosclerosis in patients with diabetes mellitus (DM). Increased white blood cell (WBC) count is related to cardiovascular disease in patients with type 2 diabetes mellitus; raised neutrophil lymphocyte ratio (NLR) is associated with metabolic syndrome. concerning a correlation between glycosylated haemoglobin (HbA1c) and NLR. Aims and objectives: The aim of the present study was to investigate the neutrophils lymphocyte ratio (NLR) and blood glucose regulation in type 2 diabetes patients. Methods: This prospective study of 6 months duration was conducted in patients with type 2 diabetes mellitus, divided into two groups according to HbA1c levels. group 1- HbA1c levels ≤ 7%; group 2-HbA1c levels > 7%. WBC, neutrophil and lymphocyte counts were determined by automated analyser, HbA1C was calculated using Afinion 2.Results: Of total 50 patients included, Random blood glucose, neutrophil , WBC counts ,NLR, HbA1C were significantly higher in group 2 compared to group 1.Conclusion:NLR of uncontrolled group (HbA1c>7%)was significantly higher than that of controlled group(HbA1C<7%) .We conclude that NLR gives us very good and similar results to know the early complications of uncontrolled DM.