bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of pottery materials in Muarojambi Temple complex and Batanghari River sediment in Jambi Province, Indonesia based on the mineralogical and petrographical analysis
Authors: Savira D , Sihombing F M H , Sulistyowati D , Indra T L
Published: July 2020

Pottery is a ceramic which generally used as household utensils or religious necessities such as spiritual ceremonies. This object has been used by society since long time ago that make it has certain historical and cultural values. One problem with pottery that it is hard to define its source. We believe that mineralogy could help finding the source of the pottery by comparing mineralogy of pottery and mineralogy of alluvial sand that usually used for pottery. This study was carried out to analyze the pottery-forming material of pottery fragments in the Muaro Jambi Temple complex and compare them with the Batanghari River sediments on the opposite to the temple. Data retrieval is done by collecting pottery fragments in the excavation field and taking sand samples in the downstream of the Batanghari River. The fragments of pottery and river sands were separated based on their texture and analyzed using microscope. Each material will be described based on its physical appearance and frequency of existence. From the study we found that minerals found in the pottery fragments from Muaro Jambi have similarity with the mineralogy of alluvial sand from Batanghari River. Thus, it might be a good indication that there is a correlation between them. From this research, we also conclude that the mineralogy characteristic could be useful for identifying the source of pottery.
Geomorphology study in relation to ground subsidence on urban area with sandbox simulation
Authors: Iskandarsyah  , Supriyanto  , Syahputra R
Published: July 2020

Ground subsidence on urban area are one of the major factors of disaster. in urban area such as Jakarta, ground subsidence is frequently occurred on main road and densely populated building. Study of surface elevation changes due to influence of groundwater movement have broadly discussed. In Many areas of subsidence caused by groundwater pumping have been identified and monitored. To understand more advance in subsidence process through direct experiment. The sandbox simulation of surface structure changes due to material movement. The simulation projects the surface elevation changes due to loss of mass.
Fabric study in metamorphic rocks in Karangsambung, Kebumen, Central Java
Authors: Putri A A O , Augusty D G , Sihombing F M H , Indra T L
Published: July 2020

Process of deFormation has an effect on both dynamic and regional metamorphic rocks. Metamorphic rock of Manunggal Formation can be found as large outcrops in Karangsambung, Central Java. In this research, we did geological mapping in the Manunggal Formation outcrop area and took rock samples. The rock samples are then analysis macroscopically to determine their metamorphic facies. From our study, we are able to identify the various degrees of metamorphism within the study area. This variation are concluded from the detailed macroscopic of mineral composition and rock texture of the rock samples from Manunggal Formation. The metamorphism process in rocks produced foliation textures on metamorphic rocks that are either foliated like phyllite and schist, or non-foliated such as green rock, serpentinite, and hornfels. All of this variation are plotted into the geological map and showing specific trend that might be related to past tectonic activity in the study area.
Lineament mapping using remote sensing and correlation on surface manifestation distribution in Gunung Endut, Banten Province, Indonesia
Authors: Tanjung F H , Dhianaufal  , Rahmadhani A U , Sihombing F M H , Sahdarani D N , Supriyanto
Published: July 2020

Remote sensing has become one of the most used methods in geothermal exploration. This technology is used to detect the presence of lineaments located in the area of geothermal exploration. The lineament can be expressed in the form of ridges and valleys. These features are closely related to the existence of geological structures. Geological structures act as weak zones (permeable zones) for the fluid to come out to the surface which will provide the circulation that forms the geothermal system. The research area is geographically located in 06°35’58” S and 106°17’01” E. Overall, the area of the research is about 325 km2 included 51 sub-districts in Lebak Regency, Province of Banten. This research area covers the entire area of Mount Endut and east of Mount Talaga and was included in the geological map of Leuwidamar dominated by Pleistocene Endut volcanic rocks (Qpv) which consists of volcanic breccia, lava, and tuff. The geological structures that developed in the study area are in the form of faults and folds. The data used in lineaments extraction were Digital Elevation Model derived from ASTER GDEM which has a vertical accuracy of 10–25 m. Meanwhile, the data on the existence of manifestations were obtained from the Geothermal Potential book published by the Geological Agency, Ministry of Energy and Mineral Resources. In extracting lineaments, the PCI Geomatica software was automatically used with the LINE algorithm. In the calculation of ground surface temperature, ENVI software is used together with The Law of Wien Shift. The general direction of alignments obtained is NNW-SSE. There are 5 unexpected faults related to the distribution of surface manifestations. The results of the structure interpretation in general show the relationship with the existence of surface ground temperature anomalies distribution. This is caused by the existence of a weak zone (permeable zone) as a place for the hot fluid to escape which will affect the surface temperature of the ground.
Identification of reservoir characteristics based on seismic velocity tomography using microearthquake method in “X” geothermal field
Authors: Fathan F , Daud Y
Published: July 2020

This research studies microearthquake (MEQ) data analysis in “X” geothermal field. The data was recorded in two phases; before and during drilling, with a total number of 2863 events recorded. The quality assessment method was applied using wadati diagram analysis in order to select the best quality data for advance processing. The result shows that the MEQ events are having trend of Vp/Vs ratio around 1.76. The MEQ data then processed using tomography inversion technique to obtain the image of subsurface seismic velocity structure. The results of seismic tomography inversion shows anomaly pattern which consistent with the lithology and geological structure. The results also shows a good agreement with the interpretation of resistivity section from magnetotelluric (MT) data, as well as from geochemical data. The region infered as reservoir zone are observed with dominantly high Vp/Vs anomaly which indicates incompressible characteristics that may relate to existence of water content, while the low Vp/Vs anomaly which indicates steam cap existence are not observed in this region. This pattern of anomaly leads to inference that the reservoir characteristics are dominated with liquid phase of fluid.
Hydrothermal alteration studies of Gunung Endut, Banten with petrographic method
Authors: Oktaviani N P , Primayudha F , Dhianaufal  , Sahdarani D N , Sihombing F M H , Supriyanto
Published: July 2020

Hydrothermal alteration is a great indicator of thermal fluid dynamics, especially in a geothermal system. Hydrothermally altered minerals are formed based on temperature and the properties of the protolith. Hydrothermal alteration samples from Gunung Endut Geothermal Working Area were analysed using petrography methods. Importance in determining the hydrothermal alteration for geothermal alteration are use as geothermometers, predict scaling and corrosion, estimate fluid pH and many more. Temperature, permeability and fluid type involved in the alteration process were identified based on the thin section observation. Majority of the samples shows the presence of clay minerals, chlorite and pyrite, indicating a moderate intensity of alteration formed under an argillic alteration environment at ≤ 180 °C. Based on the altered minerals observed under the petrographic microscopy, we then deduce that acidic fluids are the main type of fluid found in Gunung Endut Geothermal Working Area because that argillic alteration minerals showed acid environment.
Influence of Physical Mixing Ratio on Pore Development in Highly Porous Carbon Prepared From Nipa Palm Husk Using Hydrothermal Carbonization with Chemical Activation
Authors: Dechabun Sutthinan , Udomsap Parncheewa , Chollacoop Nuwong , Eiad-Ua Apiluck
Published: July 2020

In this study, porous carbon materials were prepared from nipa palm (Nypa fruiticans) husk using hydrothermal carbonization process with KOH activation through physical mixing. In order to investigate effects of factors on carbon products, hydrothermal temperature and duraton were set to 180°C and 8 hours, and KOH:hydrochar activation weight ratio at 1:1, 1:2 and 1:3, respectively. Prepared carbon materials then were carbonized at 900°C for 2 hours under nitrogen atmosphere and characterized by scanning electron microscope, fourier-transform infrared spectroscopy and x-ray diffraction. According to the results, carbon material produced using physical mixing activation ratio of 1:1 shows the most significant pore development and surface chemical properties, leads to finding a promising way to prepare environmental-friendly highly porous carbon material from biomass.
Optimization of Cutting Parameters in Machining Polyoxymethylene Using RSM
Authors: Aruna M
Published: July 2020

Polyoxymcthylene (POM) is an extensively used engineering thermoplastic polymer. Owing to its superior properties and potential applications in numerous turfs of structural machineries, it is essential to probe the machining of POM. The economy of machining operations plays an imperative role in increasing productivity and effectiveness. The persistence of optimal cutting parameters, such as cutting speed, feed and depth of cut, which are valid for given cutting tools, is one of the dynamic segments in process planning of metal parts. This research work concerns an experimental study dealing with cutting parameters and its effects on surface roughness (Ra) and material removal rate (MRR) during the turning of POM. The approach is based on Response Surface Technology (RSM). Experiments are designed using central composite design and second-order quadratic models are developed to define the optimal machining parameters. These optimized parameters are validated experimentally.
Morita equivalence of finitely presented algebras
Authors: Alahmadi Adel , Alsulami Hamed
Published: July 2020

We prove that if two algebras are Morita equivalent and one of these algebras is finitely presented, then the other one is finitely presented as well.
Global dynamics of a Wilson polynomial Liénard equation
Authors: Chen Haibo , Chen Hebai
Published: July 2020

Gasull and Sabatini in [Ann. Mat. Pura Appl. 198 (2019), pp. 1985–2006] studied limit cycles of a Liénard system which has a fixed invariant curve, i.e., a Wilson polynomial Liénard system. The Liénard system can be changed into
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="ModifyingAbove x With dot equals y minus left-parenthesis x squared minus 1 right-parenthesis left-parenthesis x cubed minus b x right-parenthesis comma ModifyingAbove y With dot equals minus x left-parenthesis 1 plus y left-parenthesis x cubed minus b x right-parenthesis right-parenthesis">

x
˙

=
y
−
(

x
2

−
1
)
(

x
3

−
b
x
)
,
 

y
˙

=
−
x
(
1
+
y
(

x
3

−
b
x
)
)

\dot x=y-(x^2-1)(x^3-bx), ~ \dot y=-x(1+y(x^3-bx))

. For

b
≤
0.7

b\leq 0.7

and

b
≥
0.76

b\geq 0.76

, limit cycles of the system are studied completely. But for

0.7
>
b
>
0.76

0.7>b>0.76

, the exact number of limit cycles is still unknown, and Gasull and Sabatini conjectured that the exact number of limit cycles is two (including multiplicities). In this paper, we give a positive answer to this conjecture and study all bifurcations of the system. Finally, we show the expanding of the moving limit cycle as

b
>
0

b>0

increases and give all global phase portraits on the Poincaré disk of the system completely.
Embedding Riemann surfaces with isolated punctures into the complex plane
Authors: Kutzschebauch Frank , Poloni Pierre-Marie
Published: July 2020

We enlarge the class of open Riemann surfaces known to be holomorphically embeddable into the plane by allowing them to have additional isolated punctures compared to the known embedding results.
Solutions of equations involving the modular 𝑗 function
Authors: Eterović Sebastian , Herrero Sebastián
Published: July 2020

Inspired by work done for systems of polynomial exponential equations, we study systems of equations involving the modular

j
j

function. We show general cases in which these systems have solutions, and then we look at certain situations in which the modular Schanuel conjecture implies that these systems have generic solutions. An unconditional result in this direction is proven for certain polynomial equations on

j
j

with algebraic coefficients.
Formidable females redux: male social integration into female networks and the value of dynamic multilayer networks
Authors: Bonnell Tyler R , Vilette Chloé , Young Christopher , Henzi Stephanus Peter , Barrett Louise
Published: July 2020

The development of multilayer network techniques is a boon for researchers who wish to understand how different interaction layers might influence each other, and how these in turn might influence group dynamics. Here, we investigate how integration between male and female grooming and aggression interaction networks influences male power trajectories in vervet monkeys Chlorocebus pygerythrus. Our previous analyses of this phenomenon used a monolayer approach, and our aim here is to extend these analyses using a dynamic multilayer approach. To do so, we constructed a temporal series of male and female interaction layers. We then used a multivariate multilevel autoregression model to compare cross-lagged associations between a male’s centrality in the female grooming layer and changes in male Elo ratings. Our results confirmed our original findings: changes in male centrality within the female grooming network were weakly but positively tied to changes in their Elo ratings. However, the multilayer network approach offered additional insights into this social process, identifying how changes in a male’s centrality cascade through the other network layers. This dynamic view indicates that the changes in Elo ratings are likely to be short-lived, but that male centrality within the female network had a much stronger impact throughout the multilayer network as a whole, especially on reducing intermale aggression (i.e., aggression directed by males toward other males). We suggest that multilayer social network approaches can take advantage of increased amounts of social data that are more commonly collected these days, using a variety of methods. Such data are inherently multilevel and multilayered, and thus offer the ability to quantify more precisely the dynamics of animal social behaviors.
Simultaneous transfemoral valve-in-valve transcatheter aortic valve replacement and debranching thoracic endovascular aortic repair through a tortuous and shaggy aorta: a case report
Authors: Kadoya Yoshito , Zen Kan , Yaku Hitoshi , Matoba Satoaki
Published: July 2020

Background

Transcatheter aortic valve replacement (TAVR) is a viable treatment option for managing aortic prosthetic valve dysfunction. Although the transfemoral approach is the most commonly used and preferred treatment strategy for TAVR, complex vascular access, such as aortic aneurysm, severe tortuosity, and shaggy aorta, is challenging.

Case summary

An 87-year-old man, who underwent surgical aortic valve replacement for aortic stenosis using a 21-mm Carpentier-Edwards Perimount Valve, presented with New York Heart Association functional Class III dyspnoea. He was diagnosed as having severe symptomatic structural valve deterioration of a bioprosthetic aortic valve. Computed tomography revealed a tortuous and shaggy descending aorta with a saccular aneurysm in the aortic arch. Simultaneous transfemoral valve-in-valve TAVR and Zone 2 thoracic endovascular aortic repair (TEVAR) with debranching were successfully performed using a 22-Fr 65-cm sheath. Although the patient developed paraplegia due to transient spinal cord ischaemia associated with TEVAR, he fully recovered with vasopressor therapy.

Discussion

To the best of our knowledge, this is the first report on simultaneous successful ‘valve-in-valve’ TAVR and debranching TEVAR using the transfemoral approach. This case demonstrated the feasibility of single-stage transfemoral TAVR and TEVAR in a high-risk patient with multicomponent disease.
Coda-wave decorrelation sensitivity kernels in 2-D elastic media: a numerical approach
Authors: Duran Alejandro , Planès Thomas , Obermann Anne
Published: July 2020

Probabilistic sensitivity kernels based on the analytical solution of the diffusion and radiative transfer equations have been used to locate tiny changes detected in late arriving coda waves. These analytical kernels accurately describe the sensitivity of coda waves towards velocity changes located at a large distance from the sensors in the acoustic diffusive regime. They are also valid to describe the acoustic waveform distortions (decorrelations) induced by isotropically scattering perturbations. However, in elastic media, there is no analytical solution that describes the complex propagation of wave energy, including mode conversions, polarizations, etc. Here, we derive sensitivity kernels using numerical simulations of wave propagation in heterogeneous media in the acoustic and elastic regimes. We decompose the wavefield into P- and S-wave components at the perturbation location in order to construct separate P to P, S to S, P to S and S to P scattering sensitivity kernels. This allows us to describe the influence of P- and S-wave scattering perturbations separately. We test our approach using acoustic and elastic numerical simulations where localized scattering perturbations are introduced. We validate the numerical sensitivity kernels by comparing them with analytical kernel predictions and with measurements of coda decorrelations on the synthetic data.
The Right to Oppose Further Commercialisation of Goods According to Art. 15(2) of the European Union Trade Mark Regulation ‒ A Balance of Interests?
Authors: Engin-Deniz Egon
Published: July 2020

This article addresses the balance between free competition and protecting the trade mark proprietor’s interests in the context of selective distribution systems for luxury goods and the right to oppose further commercialisation. Within this framework, the author suggests a flexible system concerning the legitimate reasons for such an opposition, especially regarding luxury goods in the consumer product sector. In particular, the author looks at whether distributors of parallel imported goods – often referred to as ‘grey market traders’ – should take into consideration the limitations and conditions for the distribution of goods in the European Economic Area that are imposed on contractually bound distributors by luxury brand owners, depending on the applied distribution method, the advertising and the quality of goods. The idea of an entitlement of the brand owner to oppose matters of further commercialisation of exhausted goods if the reseller does not comply with obligations which the trade mark proprietor imposes on members of his own selective distribution system regarding specific modalities of sale is also discussed.
Salivary and Serum Inflammatory Profiles Reflect Different Aspects of Inflammatory Bowel Disease Activity
Authors: Majster Mirjam , Lira-Junior Ronaldo , Höög Charlotte M , Almer Sven , Boström Elisabeth A
Published: July 2020

Background

Inflammatory bowel disease (IBD) can manifest both macroscopically and microscopically in the oral cavity; however, little is known about salivary changes in IBD. Therefore, this study aimed to assess salivary and circulatory inflammatory profiles in IBD and to compare their potential to reflect the presence and activity of IBD.

Methods

We measured 92 known inflammatory proteins in serum and in unstimulated and stimulated whole saliva samples from patients with IBD with active intestinal inflammation (n = 21) and matched control patients (n = 22) by proximity extension assay. Fifteen of the patients with IBD returned 10 to 12 weeks after treatment escalation for resampling.

Results

Sixty-seven of the proteins were detected in all 3 sample fluids but formed distinct clusters in serum and saliva. Twenty-one inflammatory proteins were significantly increased and 4 were significantly decreased in the serum of patients with IBD compared with that of the control patients. Two of the increased serum proteins, IL-6 and MMP-10, were also significantly increased in stimulated saliva of patients with IBD and correlated positively to their expressions in serum. None of the investigated proteins in serum or saliva were significantly altered by IBD treatment at follow-up. Overall, inflammatory proteins in serum correlated to biochemical status, and salivary proteins correlated positively to clinical parameters reflecting disease activity.

Conclusions

Saliva and serum inflammatory profiles in IBD share a similar composition but reflect different aspects of disease activity. The oral cavity reflects IBD through elevated IL-6 and MMP-10 in stimulated saliva.
Third-generation sequencing-based mapping and visualization of single nucleotide polymorphism, meiotic recombination, illegitimate mutation and repeat-induced point mutation
Authors: Li Wan-Chen , Liu Hou-Cheng , Lin Ying-Jyun , Tung Shu-Yun , Wang Ting-Fang
Published: July 2020

Generation of new genetic diversity by crossover (CO) and non-crossover (NCO) is a fundamental process in eukaryotes. Fungi have played critical roles in studying this process because they permit tetrad analysis, which has been used by geneticists for several decades to determine meiotic recombination products. New genetic variations can also be generated in zygotes via illegitimate mutation (IM) and repeat-induced point mutation (RIP). RIP is a genome defense mechanism for preventing harmful expansion of transposable elements or duplicated sequences in filamentous fungi. Although the exact mechanism of RIP is unknown, the C:G to T:A mutations might result from DNA cytosine methylation. A comprehensive approach for understanding the molecular mechanisms underlying these important processes is to perform high-throughput mapping of CO, NCO, RIP and IM in zygotes bearing large numbers of heterozygous variant markers. To this aim, we developed ‘TSETA’, a versatile and user-friendly pipeline that utilizes high-quality and chromosome-level genome sequences involved in a single meiotic event of the industrial workhorse fungus Trichoderma reesei. TSETA not only can be applied to most sexual eukaryotes for genome-wide tetrad analysis, it also outcompetes most currently used methods for calling out single nucleotide polymorphisms between two or more intraspecies strains or isolates.
Resection of Spinal Meningioma Using Ultrasonic BoneScalpel Microshaver: Cases, Technique, and Review of the Literature
Authors: Sadrameli Saeed Sam , Chan Tiffany Michelle , Lee Jonathan Jinhee , Desai Virendra R , Holman Paul J
Published: July 2020

BACKGROUND

Meningiomas of the spinal canal comprise up to 40% of all spinal tumors. The standard management of these tumors is gross total resection. The outcome and extent of resection depends on location, size, patient's neurologic status, and experience of the surgeon. Heavily calcified spinal meningiomas often pose a challenge for achieving gross total resection without cord injury.

OBJECTIVE

To report our experience with the BoneScalpel Micro-shaver to resect heavily calcified areas of spinal meningiomas adherent to the spinal cord without significant cord manipulation, achieving gross total resection and outstanding clinical results.

METHODS

Seventy-nine and 82-yr-old females presented with progressive leg weakness, paresthesias, and gait instability. Magnetic resonance imaging of the thoracic spine showed a homogenous enhancing intradural extramedullary mass with mass effect on the spinal cord. Midline bilateral laminectomy was performed, and the dura was open in midline. The lateral portion of the tumor away from the spinal cord was resected with Cavitron Ultrasonic Surgical Aspirator while the BoneScalpel Micro-shaver (power level 5 and 30% irrigation) was brought into the field for the calcified portion of the tumor adherent to the spinal cord.

RESULTS

Gross total resection was achieved for both cases. At the 2-wk postoperative visit, both patients reported complete recovery of their leg weakness with significant improvement in paresthesias and ataxia.

CONCLUSION

The ultrasonic osteotome equipped with a microhook tip appears to be a safe surgical instrument allowing for effective resection of spinal meningiomas or other heavily calcified spinal masses not easily removed by usual surgical instrumentation.
Ten-Step Biportal Endoscopic Transforaminal Lumbar Interbody Fusion Under Computed Tomography-Based Intraoperative Navigation: Technical Report and Preliminary Outcomes in Mexico
Authors: Quillo-Olvera Javier , Quillo-Reséndiz Javier , Quillo-Olvera Diego , Barrera-Arreola Michelle , Kim Jin-Sung
Published: July 2020

BACKGROUND

The principal advantage of intraoperative spinal navigation is the ease of screw placement. However, visualization and the integration of navigation can be explored with the use of navigation-guided full-endoscopic techniques.

OBJECTIVE

To describe the stepwise intraoperative navigation-assisted unilateral biportal endoscopic transforaminal lumbar interbody fusion (UBE-TLIF) technique and to present our preliminary results in a Mexican population.

METHODS

A 10-step summary of the UBE-TLIF operative technique was described, and the clinical and radiological results are presented and analyzed.

RESULTS

A total of 7 patients were treated. We observed the value of integrating navigation and endoscopic visualization when decompression had to be performed.

CONCLUSION

Together, intraoperative navigation and direct visualization through the endoscope may be a useful surgical tool for surgeons with experience in endoscopic spinal surgery.
In Situ Side-to-Side Pericallosal-Pericallosal Artery and Callosomarginal-Callosomarginal Artery Bypasses for Complex Distal Anterior Cerebral Artery Aneurysms: A Technical Note
Authors: Acerbi Francesco , Vetrano Ignazio G , Falco Jacopo , Gioppo Andrea , Ciuffi Andrea , Ziliani Vanessa , Schiariti Marco , Broggi Morgan , Faragò Giuseppe , Ferroli Paolo
Published: July 2020

BACKGROUND

Despite surgical and endovascular technical improvements over the last decades, the treatment of complex aneurysms of the distal anterior cerebral artery (ACA) is very challenging for both vascular neurosurgeons and interventional neuroradiologists. Furthermore, the interpersonal anatomic variability requires, most of the time, a tailored planning.

OBJECTIVE

To describe a novel technique of bypasses in the territory of ACA to protect the brain territory distal to the aneurysm.

METHODS

A 53-yr-old male with a large complex fusiform aneurysm of the left distal A2 segment of the ACA, involving the origin of the callosomarginal and pericallosal arteries, was judged not suitable for a single procedure (endovascular or neurosurgical). Two side-to-side bypasses were performed in a single surgery to connect the pericallosal and callosomarginal arteries of both sides, distally to the aneurysm. Subsequently, an endovascular embolization of the aneurysm was achieved with coils.

RESULTS

The patency of the microanastomoses, performed in the anterior interhemispheric fissure, was positively evaluated intraoperatively with indocyanine green and fluorescein videoangiography. The aneurysm sac, together with proximal A2 segment, was completely occluded with platinum coils. At the last follow-up, computed tomography angiography confirmed the patency of both bypasses, without any sign of aneurysm recanalization. The patients never complained of any focal neurological deficits or worsening of clinical status.

CONCLUSION

We present an elegant and innovative solution to completely protect the distal ACA territory in cases of complex aneurysm involving the origin of both callosomarginal and pericallosal arteries.
Brain Networks Sensitive to Object Novelty, Value, and Their Combination
Authors: Ghazizadeh Ali , Fakharian Mohammad Amin , Amini Arash , Griggs Whitney , Leopold David A , Hikosaka Okihide
Published: July 2020

Novel and valuable objects are motivationally attractive for animals including primates. However, little is known about how novelty and value processing is organized across the brain. We used fMRI in macaques to map brain responses to visual fractal patterns varying in either novelty or value dimensions and compared the results with the structure of functionally connected brain networks determined at rest. The results show that different brain networks possess unique combinations of novelty and value coding. One network identified in the ventral temporal cortex preferentially encoded object novelty, whereas another in the parietal cortex encoded the learned value. A third network, broadly composed of temporal and prefrontal areas (TP network), along with functionally connected portions of the striatum, amygdala, and claustrum, encoded both dimensions with similar activation dynamics. Our results support the emergence of a common currency signal in the TP network that may underlie the common attitudes toward novel and valuable objects.
Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity
Authors: Garcea Frank E , Greene Clint , Grafton Scott T , Buxbaum Laurel J
Published: July 2020

Producing a tool use gesture is a complex process drawing upon the integration of stored knowledge of tools and their associated actions with sensory–motor mechanisms supporting the planning and control of hand and arm actions. Understanding how sensory–motor systems in parietal cortex interface with semantic representations of actions and objects in the temporal lobe remains a critical issue and is hypothesized to be a key determinant of the severity of limb apraxia, a deficit in producing skilled action after left hemisphere stroke. We used voxel-based and connectome-based lesion-symptom mapping with data from 57 left hemisphere stroke participants to assess the lesion sites and structural disconnection patterns associated with poor tool use gesturing. We found that structural disconnection among the left inferior parietal lobule, lateral and ventral temporal cortices, and middle and superior frontal gyri predicted the severity of tool use gesturing performance. Control analyses demonstrated that reductions in right-hand grip strength were associated with motor system disconnection, largely bypassing regions supporting tool use gesturing. Our findings provide evidence that limb apraxia may arise, in part, from a disconnection between conceptual representations in the temporal lobe and mechanisms enabling skilled action production in the inferior parietal lobule.
What patient factors and Patient-Reported Outcomes Measurement Information System domains are associated with worse pain coping in pediatric orthopaedic patients in the United States?
Authors: Bernstein David N. , Fear Kathleen , Xu Zhaomin , Sanders James O. , Cook P. Christopher , Rubery Paul T. , Nelson Susan , O’Malley Natasha
Published: July 2020

We sought to better understand the relationship between Patient-Reported Outcomes Measurement Information System (PROMIS) mobility, pain interference (PI) and depressive symptoms scores, as well as determine what patient factors and PROMIS domains were associated with worse pain coping (PROMIS PI), in a pediatric orthopaedic population. Between 27 August 2015 and 30 April 2019, new pediatric orthopaedic patients 18 years or younger (or their guardians as a proxy) were asked to complete PROMIS mobility, PI and depressive symptoms domains at an academic medical center pediatric orthopaedic clinic. Pearson correlation coefficients (r) were calculated between each PROMIS domain. Linear multivariate regression analysis was used to determine patient characteristics and PROMIS domains associated with presenting PROMIS PI scores. There was a strong-moderate correlation between PROMIS mobility and PI (r = −0.66, P < 0.001), while the correlation between PROMIS mobility and depressive symptoms was moderate-poor (r = −0.38, P < 0.001). There was a moderate correlation between PROMIS depressive symptoms and PI (r = 0.54, P < 0.001). In multivariate linear regression analysis, female gender (β = 0.82, P < 0.001), self-reported black race (β = 0.94, P < 0.001), Medicaid insurance (β = 0.82, P < 0.001) and worsening depressive symptoms (β = 0.33, P < 0.001) were associated with worse pain coping mechanisms, while increasing mobility (β = −0.47, P < 0.001) was associated with better pain coping mechanisms. Poor mobility and worse depressive symptoms are associated with worse pain coping mechanisms. Additionally, Medicaid insurance status, black race and female gender are also associated with worse physical limitations secondary to pain.
A Pilot Randomized Controlled Trial of a Text Message Intervention to Promote Help Seeking for Psychiatric Outpatients
Authors: Kodama Toyohiko , Tamura Yuko , Komori Teruhisa , Kataoka Mika , Igura Kazumasa , Hashimoto Takeshi
Published: July 2020

Mental illness often affects and is affected by other diseases, such as cardiovascular disease, cancer, and AIDS/HIV infection, and people living with mental illness require additional common services and resource mobilization efforts. Therefore, we developed a mobile phone intervention and conducted a randomized controlled trial with 45 psychiatric outpatients with mental illnesses. Data from 39 individuals (intervention group: 20, control group: 19; mean [SD] age, 44.64 [14.12] years) were included in the analyses. The intervention involved the promotion of help-seeking behaviors by sending text messages, including information about social welfare services, for 3 months. After the intervention period, no significant differences were found in the proportion of help-seeking behaviors between the intervention and control groups. However, concerning the reason for not using social services, the proportion of participants who answered “I do not know how to use it” in the intervention group was significantly lower compared to the control group. More than 80% of participants in the intervention group reported that the text messaging service was helpful and useful, and they wanted more messages and information. This was the first randomized controlled trial to promote psychiatric patients' help-seeking behavior using text messaging. Moreover, the text messaging intervention was found to be cost-effective.
The Online Sharing of Instagram Images for Rheumatoid Arthritis
Authors: Lewis Deborah , Long Janice , Moss Nancy , Fowles Eileen R.
Published: July 2020

Social media use related to chronic disease has become pervasive, yet little research has been done to examine how social media is currently used by healthcare consumers or how to best use various social media platforms to improve health outcomes. The purpose of this study was to gain an understanding of Instagram use for image sharing related to #rheumatoidarthritis. A visual ethnography approach using content analysis was completed. Images for analysis (n = 106) were randomly selected, using the Instagram public search feature, during seven distinct periods. Content analysis, conducted by two coders, was used to identify categories and provide a sentiment analysis of the images. Approximately 75% of the images were determined to be positive by both coders. Social interaction and self-expression were the most frequently identified categories, suggesting that individuals use Instagram primarily for sharing awareness, sharing encouragement, and self-expression regarding rheumatoid arthritis. This finding is consistent with the use of Instagram for social networking and self-promotion. This study reveals new insights about how Instagram serves as a social, personal, and health-related information sharing platform particularly for those who may be socially isolated due to rheumatoid arthritis.
Assessment of the Patient With Intracerebral Hemorrhage
Authors: Kurian Christeena , Kaur Kavneet , Kaur Gurmeen , Sahni Ramandeep
Published: July 2020

Spontaneous nontraumatic intracerebral hemorrhage is associated with high morbidity and mortality. Given the risk of rapid neurological deterioration, early identification with rapid neuroimaging is vital. Predictors of outcome, such as spot sign and intracerebral hemorrhage score, can help guide management goals. Management should be aimed at prevention of hematoma expansion, treatment of increased intracranial pressure, and prevention of secondary brain injury and medical complications.
Histopathology of Red Tattoo Reactions
Authors: van der Bent Sebastiaan , Oyen Ellen , Rustemeyer Thomas , Jaspars Lies , Hoekzema Rick
Published: July 2020

Background:

Despite popularity of tattoos, complications may occur. In particular, red tattoo reactions due to allergic reactions are the most frequent chronic tattoo reactions. However, little is known about its histopathology and underlying pathomechanisms.

Objective:

The aim of this article is to analyze the histopathology of red tattoo reactions for diagnostic purposes and to acquire more insight into pathogenesis.

Methods:

A retrospective cross-sectional study was conducted by reviewing the histopathology of 74 skin biopsies of patients with allergic red tattoo reactions. Histopathological findings, such as inflammation patterns, inflammatory cells and pigment depth and color, were semi-quantified with an in-house validated scoring system by 2 independent senior investigators.

Results:

Histiocytes and lymphocytes were both present in >93%. Histiocytes were the predominant inflammatory cells in 74.3%, but well-defined granulomas were mostly absent (78.0%). Eosinophils were uncommon (8.1%) The predominantly histiocytic reaction combined with interface dermatitis was the main inflammation pattern (37.9%). Most biopsies showed more than one reaction pattern. Interface involvement was observed in 64.8%, despite the intended depth of standard tattoo procedures, in which pigment is placed deeper, in the upper- and mid-dermis. Statistical analyses showed a significant association between inflammation severity and pigment depth (P = 0.024). In 6 cases (8.1%) pigments could not be retrieved histologically.

Conclusions:

In this cohort we demonstrated that cutaneous reactions to red tattoo ink are frequently characterized by the combination of dermal predominantly histiocytic infiltrates and epidermal interface dermatitis. Allergic reactions to red tattoo pigments probably represent a combination of a subtype IVa and IVc allergic reaction. Clinicians should be aware of the specific histopathology of these reactions and therefore the importance of taking a diagnostic skin biopsy.
Desmoplastic Melanomas Mimicking Neurofibromas
Authors: Gerami Pedram , Kim Daniel , Zhang Bin , Compres Elsy V. , Khan Ayesha U. , Yazdan Pedram , Guitart Joan , Busam Klaus
Published: July 2020

Desmoplastic melanoma can be difficult to diagnose and on average have a significantly higher T stage at the time of diagnosis compared with conventional melanomas. Histologically, these tumors typically consist of spindle cells in a fibrous matrix. The spindle cells may display fibroblast and/or Schwann cell–like features. In this study, we describe the features of 12 cases of desmoplastic melanoma closely simulating neurofibroma. Although the spindle cells in these tumors may be indistinguishable from those of neurofibroma, features such as prominent fibroplasia (12/12), poor lateral circumscription (8/9), diffuse infiltration of subcutaneous tissue (7/9), and lymphoid aggregates (10/12) may be helpful clues to the diagnosis. No immunohistochemical markers were reliable in distinguishing neurofibroma-like desmoplastic melanomas from neurofibroma. Clinical follow-up was available in 8 cases, of which 4 were initially misdiagnosed as benign neoplasms and given no further re-excision. All 4 of these cases recurred; 2 of which showed transformation to a more aggressive phenotype.
T-Cell Lymphoblastic Lymphoma/Leukemia Presenting as a Diffuse Viral Exanthem-like Reaction: A Clinical and Histopathological Challenge
Authors: Kwock Jessica M. , Kurpiel Brett , Gru Alejandro A.
Published: July 2020

Cutaneous involvement by leukemia, or leukemia cutis, is a rare manifestation of leukemic disorders, most frequently occurring in children. The skin findings, which usually include multiple violaceous or erythematous nodules on the face, most often follow the classic presenting signs and symptoms of leukemia and occur in patients with an established primary diagnosis. Patients with T-cell acute lymphoblastic leukemia and associated leukemia cutis typically present with a solitary firm red to bluish nodule, often with an accompanying mediastinal mass, that can produce respiratory symptoms. In this article, we report a case of a patient with primary T-cell acute lymphoblastic leukemia/lymphoma presenting with a diffuse exanthem mimicking a viral illness with an associated SET-NUP214 translocation.
Drugs during lactation
Authors: Andersen Jon T. , Futtrup Tina Bergmann
Published: July 2020

Since the thalidomide scandal in the 1960s use of drugs during pregnancy and lactation has often been associated with great uncertainty, since it can affect both the mother and the breastfed child. However, the concern may mistakenly lead to nonharmful drugs being attributed harmful adverse drug reactions leading to undertreatment of the mother of unnecessary discontinuation of breastfeeding. The safety of the most commonly used drugs in lactation is in the following being discussed. Furthermore, a practical guide to risk assessment and considerations when initiating a drug treatment is presented.
Association of phthalate exposure and endogenous hormones with self-reported sleep disruptions: results from the Midlife Women's Health Study
Authors: Hatcher Katherine M. , Smith Rebecca L. , Chiang Catheryne , Li Zhong , Flaws Jodi A. , Mahoney Megan M.
Published: July 2020

Objective:

Follicle-stimulating hormone and estradiol (E2) have been associated with sleep in midlife women, however, few studies have examined the association of other hormones or environmental chemical exposure such as phthalates, with self-reported sleep quality. We assessed the relationship of self-reported sleep with hormones and phthalates.

Methods:

In total, 762 women (aged 45-54 y, 459 premenopausal, and 303 perimenopausal) from the Midlife Women's Health Study answered self-reported questions regarding the frequency of sleep disturbances, insomnia, and restless sleep. Serum E2, progesterone, testosterone, serum hormone binding globulin, free E2 index, free testosterone index, E2:progesterone, and E2:testosterone were measured. Summary measures of phthalate mixtures, including the phthalates from plastic sources (sumPLASTIC), personal care products (sumPCP), di-(2-ethyhexyl) phthalate (sumDEHP), anti-androgenic phthalates (sumAA), and all phthalate metabolites measured (sumALL), were calculated from urinary phthalate metabolites. Ordinal logistic regression was used to fit each outcome sleep measure with all hormones and summary phthalates.

Results:

Progesterone and testosterone were significantly negatively associated with the frequency of sleep disturbances and insomnia. Free testosterone index was also negatively associated with insomnia frequency. E2:progesterone was positively associated with frequency of sleep disturbances and restless sleep in self-reported nonsmokers. SumPCP and sumALL were significantly negatively associated with frequency of sleep disturbances, insomnia, and restless sleep. SumDEHP and sumPLASTIC were negatively associated with insomnia frequency. Further, the direction of association between phthalates and sleep appears to be dependent on the quartile of phthalate exposure. All significant associations between phthalates and sleep were in self-reported nonsmokers or former smokers.

Conclusions:

Our study supports previous literature that hormones beyond follicle-stimulating hormone and E2 are associated with sleep disruptions in menopause. Further, we are among the first to show that phthalate exposure is associated with sleep disruptions in midlife women.
LONG-TERM EFFECT OF CYSTOTOMY WITH OR WITHOUT THE FIBRINOGEN CLOT REMOVAL FOR REFRACTORY CYSTOID MACULAR EDEMA SECONDARY TO DIABETIC RETINOPATHY
Authors: Imai Hisanori , Tetsumoto Akira , Yamada Hiroko , Hayashida Mayuka , Otsuka Keiko , Miki Akiko , Kusuhara Sentaro , Nakamura Makoto
Published: July 2020

Purpose:

To show the long-term effect of cystotomy with or without fibrinogen clot removal for refractory cystoid macular edema secondary to diabetic retinopathy.

Methods:

Retrospective analyses of the medical records of 30 eyes of 30 patients with refractory cystoid macular edema secondary to diabetic retinopathy who had followed up for 12 months after the surgery were performed.

Results:

There were 15 men and 15 women. The mean ± SD age was 68.4 ± 7.9 years. The best-corrected visual acuity (logarithm of the minimal angle of resolution) at 12 months after the surgery (0.33 ± 0.25, Snellen equivalent, 20/42) was statistically better than the preoperative best-corrected visual acuity (0.45 ± 0.33, Snellen equivalent, 20/56) (P < 0.01). The central sensitivity on microperimetry (dB) was not statistically changed between preoperatively (24.0 ± 4.9) and 12 months after the surgery (24.1 ± 4.0) (P = 0.75). The central retinal thickness on optical coherence tomography (μm) at 12 months after the surgery (300.3 ± 99.0) was statistically improved compared with the preoperative central retinal thickness (565.6 ± 198.7) (P < 0.01). During the follow-up period, cystoid macular edema relapsed in seven of 30 eyes. The preoperative cystoid cavity reflectivity on optical coherence tomography in patients with fibrinogen clot removal (n = 16) was significantly higher than that in patients without fibrinogen clot removal (n = 14) (P < 0.04).

Conclusion:

The cystotomy with or without fibrinogen clot removal may be a promising treatment option for refractory cystoid macular edema secondary to diabetic retinopathy.