bluuebunny/crossref_metadata_2025 huggingface dataset:
Recommendations, Practices and Infrastructural Model for the Dental Radiology Set-up in Clinical and Academic Institutions in the COVID-19 Era
Authors: A Anu Sushanth. , Srivastava Kumar Chandan , Shrivastava Deepti , Hosni Hala A. , Khan Zafar Ali , Al-Johani Khalid , Alzoubi Ibrahim A , B Sasirekha , Sghaireen Mohammed Ghazi , Alam Mohammad Khursheed
Published: October 2020

The pandemic of Coronavirus disease (COVID-19) has emerged as a global catastrophe that is plaguing mankind. In the past eight months since the world discovered about COVID-19, we learned a lot about server acute respiratory syndrome coronavirus 2 (SARS CoV-2) and perhaps there is much more to discover and understand about the virus. With the current understanding of the disease, we assume it will remain in an active state of transmission and progression among the community for a long time. Thus, it is advisable to adopt the disease’s prevention protocol in our daily and work routine. During this pandemic patient requiring dental treatment cannot be neglected and the role of dental imaging is crucial in delivering treatment. Hence, this article attempts to provide an evidence-based compilation about the mode of transmission and clinical features of COVID-19. It also throws light on the potential source of disease transmission in the dental radiology setting. In addition, it suggests preventive measures to curb the infection and infrastructural model of the clinical setting that will assist in achieving control over the disease transmission. This article intends to project a strategy about protocols, infrastructure, and daily activities in a dental radiology office that institutions can adopt with modifications according to their local scenario.
An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target
Authors: Hong Sung-Jun , Kim Jin-Tae , Kim Su-Jung , Cho Nam-Chul , Kim Kyeojin , Lee Seungbeom , Suh Young-Ger , Cho Kyung-Cho , Kim Kwang Pyo , Surh Young-Joon
Published: October 2020

Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment. Persistent STAT3 activation in malignant cells stimulates proliferation, survival, angiogenesis, invasion, and tumor-promoting inflammation. STAT3 undergoes activation through phosphorylation on tyrosine 705, which facilitates its dimerization. Dimeric STAT3 translocates to the nucleus, where it regulates the transcription of genes involved in cell proliferation, survival, etc. In the present study, a synthetic deguelin analogue SH48, discovered by virtual screening, inhibited the phosphorylation, nuclear translocation, and transcriptional activity of STAT3 in H-ras transformed human mammary epithelial MCF-10A cells (MCF10A-ras). We speculated that SH48 bearing an α,β-unsaturated carbonyl group could interact with a thiol residue of STAT3, thereby inactivating this transcription factor. Non-electrophilic analogues of SH48 failed to inhibit STAT3 activation, lending support to the above supposition. By utilizing a biotinylated SH48, we were able to demonstrate the complex formation between SH48 and STAT3. SH48 treatment to MCF10A-ras cells induced autophagy, which was verified by staining with a fluorescent acidotropic probe, LysoTracker Red, as well as upregulating the expression of LC3II and p62. In conclusion, the electrophilic analogue of deguelin interacts with STAT3 and inhibits its activation in MCF10A-ras cells, which may account for its induction of autophagic death.
Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction
Authors: Osman Aisha , Benameur Tarek , Korashy Hesham M. , Zeidan Asad , Agouni Abdelali
Published: October 2020

Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at restoring the proper function of the ER. Prolonged activation of the UPR leads, however, to ER stress, a cellular state that contributes to the pathogenesis of various chronic diseases including obesity and diabetes. ER stress response by itself can result in endothelial dysfunction, a hallmark of cardiovascular disease, through various cellular mechanisms including apoptosis, insulin resistance, inflammation and oxidative stress. Extracellular vesicles (EVs), particularly large EVs (lEVs) commonly referred to as microparticles (MPs), are membrane vesicles. They are considered as a fingerprint of their originating cells, carrying a variety of molecular components of their parent cells. lEVs are emerging as major contributors to endothelial cell dysfunction in various metabolic disease conditions. However, the mechanisms underpinning the role of lEVs in endothelial dysfunction are not fully elucidated. Recently, ER stress emerged as a bridging molecular link between lEVs and endothelial cell dysfunction. Therefore, in the current review, we summarized the roles of lEVs and ER stress in endothelial dysfunction and discussed the molecular crosstalk and relationship between ER stress and lEVs in endothelial dysfunction.
Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential
Authors: Cvetko Ana , Kifer Domagoj , Gornik Olga , Klarić Lucija , Visser Elizabeth , Lauc Gordan , Wilson James F. , Štambuk Tamara
Published: October 2020

Multiple sclerosis (MS) is an inflammatory autoimmune disorder affecting the central nervous system (CNS), with unresolved aetiology. Previous studies have implicated N-glycosylation, a highly regulated enzymatic attachment of complex sugars to targeted proteins, in MS pathogenesis. We investigated individual variation in N-glycosylation of the total plasma proteome and of IgG in MS. Both plasma protein and IgG N-glycans were chromatographically profiled and quantified in 83 MS cases and 88 age- and sex-matched controls. Comparing levels of glycosylation features between MS cases and controls revealed that core fucosylation (p = 6.96 × 10−3) and abundance of high-mannose structures (p = 1.48 × 10−2) were the most prominently altered IgG glycosylation traits. Significant changes in plasma protein N-glycome composition were observed for antennary fucosylated, tri- and tetrasialylated, tri- and tetragalactosylated, high-branched N-glycans (p-value range 1.66 × 10−2–4.28 × 10−2). Classification performance of N-glycans was examined by ROC curve analysis, resulting in an AUC of 0.852 for the total plasma N-glycome and 0.798 for IgG N-glycome prediction models. Our results indicate that multiple aspects of protein glycosylation are altered in MS, showing increased proinflammatory potential. N-glycan alterations showed substantial value in classification of the disease status, nonetheless, additional studies are warranted to explore their exact role in MS development and utility as biomarkers.
Native T1 Mapping Magnetic Resonance Imaging as a Quantitative Biomarker for Characterization of the Extracellular Matrix in a Rabbit Hepatic Cancer Model
Authors: Keller Sarah , Borde Tabea , Brangsch Julia , Adams Lisa C. , Kader Avan , Reimann Carolin , Gebert Pimrapat , Hamm Bernd , Makowski Marcus
Published: October 2020

To characterize the tumor extracellular matrix (ECM) using native T1 mapping magnetic resonance imaging (MRI) in an experimental hepatic cancer model, a total of 27 female New Zealand white rabbits with hepatic VX2 tumors were examined by MRI at different time points following tumor implantation (day 14, 21, 28). A steady-state precession readout single-shot MOLLI sequence was acquired in a 3 T MRI scanner in prone position using a head-neck coil. The tumors were segmented into a central, marginal, and peritumoral region in anatomical images and color-coded T1 maps. In histopathological sections, stained with H&E and Picrosirius red, the regions corresponded to central tumor necrosis and accumulation of viable cells with fibrosis in the tumor periphery. Another region of interest (ROI) was placed in healthy liver tissue. T1 times were correlated with quantitative data of collagen area staining. A two-way repeated-measures ANOVA was used to compare cohorts and tumor regions. Hepatic tumors were successfully induced in all rabbits. T1 mapping demonstrated significant differences between the different tumor regions (F(1.43,34.26) = 106.93, p < 0.001) without interaction effects between time points and regions (F(2.86,34.26) = 0.74, p = 0.53). In vivo T1 times significantly correlated with ex vivo collagen stains (area %), (center: r = 0.78, p < 0.001; margin: r = 0.84, p < 0.001; peritumoral: r = 0.73, p < 0.001). Post hoc tests using Sidak’s correction revealed significant differences in T1 times between all three regions (p < 0.001). Native T1 mapping is feasible and allows the differentiation of tumor regions based on ECM composition in a longitudinal tumor study in an experimental small animal model, making it a potential quantitative biomarker of ECM remodeling and a promising technique for future treatment studies.
Cybersecurity in Intelligent Transportation Systems
Authors: Mecheva Teodora , Kakanakov Nikolay
Published: October 2020

Intelligent Transportation Systems (ITS) are emerging field characterized by complex data model, dynamics and strict time requirements. Ensuring cybersecurity in ITS is a complex task on which the safety and efficiency of transportation depends. The imposition of standards for a comprehensive architecture, as well as specific security standards, is one of the key steps in the evolution of ITS. The article examines the general outlines of the ITS architecture and security issues. The main focus of security approaches is: configuration and initialization of the devices during manufacturing at perception layer; anonymous authentication of nodes in VANET at network layer; defense of fog-based structures at support layer and description and standardization of the complex model of data and metadata and defense of systems, based on AI at application layer. The article oversees some conventional methods as network segmentation and cryptography that should be adapted in order to be applied in ITS cybersecurity. The focus is on innovative approaches that have recently been trying to find their place in ITS security strategies. These approaches includes blockchain, bloom filter, fog computing, artificial intelligence, game theory and ontologies. In conclusion, a correlation is made between the commented methods, the problems they solve and the architectural layers in which they are applied.
A Simple Mechanism Causing Wealth Concentration
Authors: Cieśla Michał , Snarska Małgorzata
Published: October 2020

We study mechanisms leading to wealth condensation. As a natural starting point, our model adopts a neoclassical point of view, i.e., we completely ignore work, production, and productive relations, and focus only on bilateral link between two randomly selected agents. We propose a simple matching process with deterministic trading rules and random selection of trading agents. Furthermore, we also neglect the internal characteristic of traded goods and analyse only the relative wealth changes of each agent. This is often the case in financial markets, where a traded good is money itself in various forms and various maturities. We assume that agents trade according to the rules of utility and decision theories. Agents possess incomplete knowledge about market conditions, but the market is in equilibrium. We show that these relatively frugal assumptions naturally lead to a wealth condensation. Moreover, we discuss the role of wealth redistribution in such a model.
Accelerating Event Detection with DGCNN and FPGAs
Authors: Han Zhe , Jiang Jingfei , Qiao Linbo , Dou Yong , Xu Jinwei , Kan Zhigang
Published: October 2020

Recently, Deep Neural Networks (DNNs) have been widely used in natural language processing. However, DNNs are often computation-intensive and memory-expensive. Therefore, deploying DNNs in the real world is very difficult. In order to solve this problem, we proposed a network model based on the dilate gated convolutional neural network, which is very hardware-friendly. We further expanded the word representations and depth of the network to improve the performance of the model. We replaced the Sigmoid function to make it more friendly for hardware computation without loss, and we quantized the network weights and activations to compress the network size. We then proposed the first FPGA (Field Programmable Gate Array)-based event detection accelerator based on the proposed model. The accelerator significantly reduced the latency with the fully pipelined architecture. We implemented the accelerator on the Xilinx XCKU115 FPGA. The experimental results show that our model obtains the highest F1-score of 84.6% in the ACE 2005 corpus. Meanwhile, the accelerator achieved 95.2 giga operations (GOP)/s and 13.4 GOPS/W in performance and energy efficiency, which is 17/158 times higher than the Graphics Processing Unit (GPU).
Automated Volume Status Assessment Using Inferior Vena Cava Pulsatility
Authors: Mesin Luca , Roatta Silvestro , Pasquero Paolo , Porta Massimo
Published: October 2020

Assessment of volume status is important to correctly plan the treatment of patients admitted and managed by cardiology, emergency and internal medicine departments. Non-invasive assessment of volume status by echography of the inferior vena cava (IVC) is a promising possibility, but its clinical use is limited by poor reproducibility of current standard procedures. We have developed new algorithms to extract reliable information from non-invasive IVC monitoring by ultrasound (US) imaging. Both long and short axis US B-mode video-clips were taken from 50 patients, in either hypo-, eu-, or hyper-volemic conditions. The video-clips were processed to extract static and dynamic indexes characterizing the IVC behaviour. Different binary tree models (BTM) were developed to identify patient conditions on the basis of those indexes. The best classifier was a BTM using IVC pulsatility indexes as input features. Its accuracy (78.0% when tested with a leave-one-out approach) is superior to that achieved using indexes measured by the standard clinical method from M-mode US recordings. These results were obtained with patients in conditions of normal respiratory function and cardiac rhythm. Further studies are necessary to extend this approach to patients with more complex cardio-respiratory conditions.
Research on Optimization of VR Welding Course Development with ANP and Satisfaction Evaluation
Authors: Chung Chih-chao , Tung Chun-Chun , Lou Shi-Jer
Published: October 2020

The purpose of this study is to explore the ability indices of VR (virtual reality) technology when it is applied to assist the teaching of a welding practice course, develop a VR welding course as the basis of course planning and teaching design, and implement experimental teaching to verify its effectiveness. On the basis of a literature review and focus group interviews, initial ability indices of a VR welding course were proposed. Then, 15 experts from VR- and welding-related specialties were invited to form a consulting team to determine “the ability indices of the VR welding course” according to the results of a Fuzzy Delphi expert questionnaire. Moreover, the results of an ANP (Analytic Network Process) expert questionnaire were used to understand the relative importance of the ability indices of the VR welding course, as well as the relative feasibility of VR-assisted welding teaching, in order to develop a “VR welding course”, in which 34 first-grade students of the welding practice course were taken as the research objects during the implementation of experimental teaching. The qualitative research and analysis results are as follows: (1) the VR welding course includes 8 ability indices and 30 evaluation indices; (2) the item with the highest feasibility in VR-assisted welding teaching is “welding construction”, followed by “map reading and drawing”; (3) best feasibility of VR technology “Interaction” in assisting welding teaching; (4) the relative importance of the ability indices of the VR welding course is the greatest for “welding construction”, followed by “welding inspection”; (5) the VR welding course students express significant positive responses to the learning of ability indices and ability demonstration; (6) the majority of students express significant positive learning satisfaction with VR-assisted welding course teaching. This study puts forward a set of rigorous models for the construction of ability indices for a VR course and course development. It can provide a reference for introducing VR-assisted teaching to related welding courses that are run by universities of science and technology in Taiwan. Furthermore, such VR courses can offer students a safe, diversified, and efficient learning environment.
The Role of Perceived Social Support in Assessing Posttraumatic Stress Disorder and Mental Health-Related Quality of Life in Veterans
Authors: Jukić Melita , Lukinac Ana Marija , Požgain Ivan , Talapko Jasminka , Jukić Marko , Filaković Pavo
Published: October 2020

This study aims to establish the effect of self-perceived social support on the intensity of Post-Traumatic Stress Disorder (PTSD) symptoms and Mental Health-Related Quality of Life (MHRQoL) in veterans more than two decades after exposure to trauma in the Homeland War in Croatia, which took place from 1990 to 1995. The sample comprised 259 Croatian Homeland War veterans diagnosed with PTSD, with at least 6 months of combat experience. Among them, 90 subjects had also experienced imprisonment in enemy prison camps (at least 1 month of captivity). The subjects were evaluated using the questionnaire on self-perceived social support, sociodemographic questionnaire, PTSD self-report checklist (PCL-5) and Short Form (SF-36) Health Survey questionnaire. A general regression model analysis was performed to determine whether social support affected patients’ MHRQoL and intensity of the PTSD symptoms. The obtained results showed that veterans who had a more positive perception of social support after the events of the war had less intense PTSD symptoms and better MHRQoL. Furthermore, captivity and socioeconomic status were shown to be important predictors of PTSD and MHRQoL. The nonimprisoned veteran group was more likely to develop more severe PTSD symptoms and have poorer MHRQoL compared to the group of former prisoners of war (ex-POWs). This could be due to better post-war care and social support, which ex-POWs received after their release from captivity.
Variations in Subscapularis Muscle Innervation—A Report on Case Series
Authors: Siwetz Martin , Hammer Niels , Ondruschka Benjamin , Kieser David C.
Published: October 2020

Background and objectives: The subscapularis muscle is typically innervated by two distinct nerve branches, namely the upper and lower subscapular nerve. These usually originate from the posterior cord of the brachial plexus. A large number of variations have been described in previous literature. Materials and Methods: Dissection was carried out in 31 cadaveric specimens. The frequency of accessory subscapular nerves was assessed and the distance from the insertion points of these nerves to the myotendinous junction was measured. Results: Accessory subscapular nerves were found in three cases (9.7%). According to their origin from the posterior cord of the brachial plexus proximal to the thoracodorsal nerve all three nerves were identified as accessory upper subscapular nerves. No accessory lower subscapular nerves were found. Conclusion: Accessory nerves occur rather commonly and need to be considered during surgery, nerve blocks, and imaging procedures.
An evaluation of the efficiency of beekeeping enterprises in Hatay province with data envelopment analysis
Authors: KAYA Ufuk , GÜRCAN Safa
Published: October 2020

This study was aimed to determine technical and economic efficiency in beekeeping enterprises and to reveal the factors effecting the efficiency scores. The material of the current study consisted of the data obtained from 46 enterprises in Hatay province. Efficiency scores for technical and economical properties were determined with data envelopment analysis. The truncated regression model was used to determine the factors effecting the efficiency scores. The efficiency scores for technical and economical properties were calculated as 0.97 and 0.94, respectively. The results showed that ‘experience’, ‘race of bee’, ‘education level’ and ‘number of colony’ variables were found to be statistically significant factors on efficiency of technical properties. No significant factors were found on efficiency of economic properties. In conclusion, it was revealed what conditions should be had in terms of technical and economical properties to be performed an efficient beekeeping activity in Hatay province.
A RELAÇÃO ENTRE CIDADANIA, DIREITOS HUMANOS E DESENVOLVIMENTO REGIONAL
Authors: Ribamar Mendes Júnior José , Barreto Oliveira Tarsis
Published: October 2020

A discussão no meio acadêmico e científico a respeito da relação entre os direitos humanos, a cidadania, o exercício da cidadania e o desenvolvimento regional é de suma importância. Convém estudar de que forma o entendimento das referidas concepções atuam como elementos propulsores desse avanço local, uma vez que um ambiente participativo e democrático funciona de modo substancial para o progresso; além disso, é relevante a busca pelo desenvolvimento de sujeitos ativos, portadores de visão crítica, que possam atuar como multiplicadores de conhecimento e como protagonistas de suas próprias histórias, bem como sejam capazes de remodelar a realidade local, sendo agentes transformadores do ambiente discriminatório e desigual, combatentes das violações aos direitos. A fim de que sobrevenha o desenvolvimento permanente da região, bem assim daqueles que a integram, é pertinente que haja a identificação das características próprias da localidade e ao mesmo tempo o reconhecimento de suas qualidades e potencialidades, além de uma exploração dos meios acessíveis, estimulação da atuação e cooperação dos atores que compõem o território. É nesse sentido que uma das estratégias para se conceber o desenvolvimento regional é apreendendo os conceitos de direitos humanos, de cidadania e seu exercício, e, do mesmo modo, verificar de que forma ocorre o desencadeamento dessas perspectivas no próprio avanço local.
MICROSSISTEMA DAS PENAS ALTERNATIVAS: ANÁLISE GERENCIAL E NORMATIVA DA FASE COGNITIVA
Authors: Gagliardi Ricardo , Medina Patricia
Published: October 2020

Alicerçado em investigação exploratória e predominantemente quantitativa, o estudo diagnostica o microssistema de penas alternativas em todas as comarcas de menor porte do estado do Tocantins, em sua fase processual cognitiva, a partir dos parâmetros da eficiência e da eficácia. A pesquisa documental, relacionada à busca de ações e execuções penais, concatenou-se com os processos baixados entre os anos de 2015 e 2016, como critério de corte. Paralelamente, empreenderam-se revisões sistemáticas de literatura e de jurisprudência. Sua base teórica identifica-se ao modelo criminológico de terceira geração das inter-relações sociais, especialmente à teorização da criminologia clínica de inclusão social. Conclui-se que o microssistema das penas alternativas está em pleno funcionamento e tem amplas condições de melhorias. Há uma adequada estrutura de meios e de pessoal. De outro modo, detectam-se problemas de tempo na tramitação do processo (morosidade extrema) e de qualidade quanto aos padrões estabelecidos. O funcionamento do serviço não pode ser considerado eficiente e eficaz na perspectiva gerencial; portanto, não se demonstra efetivo. Na perspectiva normativa, sua ineficácia está adstrita a algumas hipóteses legais.
BREVES CONSIDERAÇÕES SOBRE A LITIGÂNCIA DE INTERESSE PÚBLICO: CARACTERIZAÇÃO, DIREITOS TUTELADOS E EXECUTABILIDADE DAS DECISÕES JUDICIAIS PROFERIDAS
Authors: Bedetti Bastos Mayrink Henrique
Published: October 2020

Este trabalho aborda a litigância de interesse público como instrumento de efetivação de políticas públicas indevidamente implementadas pelo poder público. Aborda-se, em primeiro lugar, o delineamento doutrinário do conceito jurídico indeterminado de interesse público. Em segundo lugar, passa-se à análise dos direitos e interesses tutelados pela litigância em apreciação, quais sejam: difusos, coletivos e individuais homogêneos. Por fim, mas não menos importante, trata-se da natureza jurídica do provimento judicial proferido e a sua respectiva executabilidade, considerando-se sempre as peculiaridades dos litígios e a dificílima questão de satisfazer plenamente os direitos dos litigantes.
DESJUDICIALIZAÇÃO – ACESSO À JUSTIÇA E DIREITOS INDISPONÍVEIS – COMO EQUACIONAR OS NOVOS PARADIGMAS SOCIAIS ENTRE O JUDICIAL E O EXTRAJUDICIAL
Authors: Gonzaga Alves Junior Mauro
Published: October 2020

No presente artigo, sem pretensão de esgotar o tema, pretendemos analisar de que forma a desjudicialização pode contribuir no efetivo acesso à justiça, bem como auxiliar para maior celeridade e efetividade do Poder Judiciário. Entretanto, ousamos avançar sobre questões na maioria das vezes intocáveis, como os chamados “direitos indisponíveis”, em que, para nós, existe uma larga parcela desses direitos que admitem a resolução, ou, ao menos a tentativa pela via extrajudicial. De posse da proposta inaugural, vislumbramos debater como a mediação e a conciliação notariais podem auxiliar no acesso a uma ordem jurídica justa e à pacificação social pela prevenção consensual de litígios. Para o desenvolvimento desta pesquisa, foi utilizado o método dedutivo, além de pesquisas bibliográficas.
CRIME CONTROL OU DOING BUSINESS : QUELLE POLITIQUE PENALE EN MATIERE ECONOMIQUE ET FINANCIERE?
Authors: Golovko Léonid
Published: October 2020

Comment expliquer certaines tentatives de prévoir des dispositions pénales déragatoires en matière économique et financière, notamment en procédure pénale ? Il est possible de dégager deux logiques hypothétiques, celle duCrime Control, où le droit pénal doit devenir plus efficace dans la lutte contre la criminalité économique et financière, et celle duDoing Business, où le droit pénal doit quasiment disparaître du champs économique pour ne pas nuire à l’activité commerciale. Le droit pénal russe se présenteactuellement,plutôt comme un exemple du mouvement Doing Business, ce qui apporte plus de problèmes que de résultats positifs. Il en résulte que la logique Doing Business ne peut être un principe de politique pénale en matière économique et financière.
OS DIREITOS HUMANOS COMO PRIMADO DE UM SENTIDO HOLÍSTICO DE EDUCAÇÃO PARA O DESENVOLVIMENTO EM CONTEXTO DE MULTICULTURALIDADE
Authors: Silvino de Pina Zau Filipe Silvino de Pina Zau
Published: October 2020

A história e as culturas africanas não são conhecidas pelos antigos países colonizadores europeus, nem pelos países que têm elevada taxa de afrodescendentes na sua população, devido ao tráfico negreiro, que, no Brasil, terminou com a “Lei Eusébio de Queirós”, de 4 de fevereiro de 1850. Actualmente, o papel socioeconómico e cultural dos negros no desenvolvimento das antigas sociedades escravocratas não é relatado nas historiografias oficiais desses países e permanece o discurso da “raça”, como justificação da escravatura e do próprio tráfico de escravos. A globalização fez crescer as desigualdades que existiam entre os países ricos e os países pobres, assim como as desigualdades no interior de cada sociedade, com uma elevada perda de valores necessários ao primado da paz, da democracia, do Estado de direito, da justiça social e dos direitos humanos. As novas gerações terão de ser formadas, no contexto de um sentido amplo de educação para a solidariedade e para o desenvolvimento, que torne possível o progresso económico e o bem-estar social, a partir do respeito ao direito de ser diferente em cada sociedade.
ARCHIVE DOCUMENTS ON THE HISTORY OF THE VORONEZH FOREST MANAGEMENT (XIX - THE BEGINNING OF THE XX CENTURY)
Authors: Semenova Elena
Published: October 2020

The article discusses the source base of the research on the history of forestry in the Voronezh province in the 19th - early 20th centuries. These are mainly archival materials stored in the State Archive of the Voronezh Region. A list of the main archival funds with a brief description of their contents is given. The analysis of the information richness of these materials and the possibility of their use in studying the history of forestry in the Voronezh province is given. The article also provides data on the history of state institutions engaged in forestry in the Voronezh province - the Voronezh chamber of state property, the provincial administration of state property, the provincial administration of agriculture and state property, the Forest Protection Committee. The characteristic of archival materials related to their history is given. The article also provides data on archival materials related to the activities of individual forestries of the Voronezh province, and their characteristics. A concrete example is given of how archival documents from central and local authorities provide conflicting information. Based on a review of the documents stored in the collections of the State Archive of the Voronezh Region, the author concludes about the richness and variety of archival materials on the history of forestry in the Voronezh province in the 19th and early 20th centuries.
WAYS TO IMPROVE THE QUALITY OF MAINTENANCE AND REPAIR OF LOGGING VEHICLES
Authors: Yakovlev Konstantin , Legostaev Sergey , Sklyarov I.
Published: October 2020

The article discusses ways to improve the quality of maintenance and maintenance of forest vehicles. Product quality is a controlled object that can be adjusted on the basis of the principles of general control theory, sequentially establishing quality planning tasks, organizing the actions of the actuator with ensuring the execution of these tasks, comparing the actual value of the obtained result with the planned task, implementing direct and reverse connections and possibilities of influencing the actuator in case of deviations of actual quality values from the planned task.

The goal of quality management is to create products of a quality level that meets certain needs and demands of the consumer, meets the established requirements.

Quality management is an organic component of the overall enterprise management system. All employees of the enterprise, including quality service personnel, participate in quality management and assurance.

The principles of operating quality systems at maintenance and repair enterprises (customer orientation; leadership of heads; Involvement of employees, process and system approaches to quality management, continuous improvement of the system, decision-making based on information monitoring) and factors affecting the quality of works (spare parts for units; timeliness of maintenance; quality of technical diagnosing; Qualification and motivation of employees).
ON THE ISSUE OF PREPARATION OF CUTTING TOOLS FOR SAWING TIMBER ON BAND SAW EQUIPMENT
Authors: Maksimenkov Alexey , Bagno O.
Published: October 2020

the main drawback of circular sawing machines is the presence of broken teeth in the cut. In case of vibrations, violation of the saw plane, mismatch of the feed direction with the saw planes, and rebasing, these teeth spoil the processing surface. Belt sawing allows you to ensure high quality of lumber on the roughness of their surface at high feed rates; increase productivity by 1.5-2 times due to mechanization and automation of technological operations. One of the most important advantages of band saws is the small width of the cut, which is 1.5-2 times smaller than that of the sawmill; the small thickness of the saw ensures low consumption of wood in sawdust and high volume output of lumber. Sawing wood on band saws, in the vast majority of cases, is characterized by face cutting. Of the 3 forms of chip formation when cutting into the end, for band saws, the most characteristic is the formation of the chip element by chipping it with the stratification of wood along the bottom of the cut. The quality of the surface, in terms of its roughness, in addition to the formation of the chip element, is affected by its location in the interdental space, the presence and degree of compression and transportation of the chip element. The quality of the surface, in terms of its roughness, in addition to the formation of the chip element, is affected by its location in the interdental space, the presence and degree of compression and transportation of the chip element. As a result of studies of the initial conditions for the development of the teeth sharpening scheme, the orientation of the active elements of the blade relative to the middle plane of the saw can be identified as the main ones.
PNEUMO-HYDRAULIC TRACTION AND COUPLING DEVICE OF A FORESTRY CAR WITH TRAILER
Authors: Nikonov Vadim , Posmetev Valeriy , Siz'min I.
Published: October 2020

The urgency of the need for constructive improvement of the towing device of a forest car with a trailer, aimed at increasing its reliability, reducing metal consumption, reducing fuel consumption of a forest car with a trailer due to the accumulation and reuse in the process of energy that is not efficiently dissipated into the environment of the energy generated in the traction coupling device when driving a road train. The conditions for the removal of forest materials by a timber truck with a trailer in the conditions of logging are described. The basic regulatory documents governing the requirements for the design of towing devices are considered. The main transient processes during the movement of a forest car with a trailer are described, which contribute to the appearance of large dynamic loads from the inertia of the forest car and trailer in the towing device. A promising design of a pneumatic-hydraulic towing device of a forest car with a trailer is proposed, which allows converting kinetic energy that inevitably arises in the towing device from the inertia forces of the masses of a forest car and trailer to potential for its further useful use in technological hydraulic equipment of a forest car with a trailer . The device and the operation of the pneumatic-hydraulic towing device of a forest car with a trailer are described. It is established that the use of the developed device will reduce fuel consumption, increase reliability and improve the smoothness of the forest car with a trailer.
PROMISING DESIGN OF A RECUPERATIVE SPRING-HYDRAULIC FIFTH WHEEL TRAILER TRUCK WITH A SEMITRAILER
Authors: Posmetev Valeriy , Nikonov Vadim , Avdyuhin Aleksandr
Published: October 2020

The relevance of the development and use of new promising designs of fifth wheel coupling devices for forestry tractors with semitrailers, aimed at ensuring the simplicity of the design of fifth wheel coupling devices, their high reliability, safety in work, reducing metal consumption and the possibility of accumulating and using energy that is not efficiently dissipated into the environment, is substantiated. The operating conditions of timber tractors with semitrailers for timber removal are described. The main transients occurring in the fifth wheel coupling and contributing to the emergence in it of large dynamic loads from the inertia of the mass of the semitrailer are given. A promising design of a recuperative spring-hydraulic fifth wheel trailer truck with a semitrailer is proposed, which allows to reduce the energy losses that occur in the fifth wheel trailer, to accumulate and is useful to use in the hydraulic drive of the manipulator during the loading and unloading of timber. The device and operation of the regenerative spring-hydraulic fifth wheel coupling are described. It was revealed that the use of the proposed device will improve ride smoothness and reduce fuel consumption of the forest tractor with a semitrailer, as well as provide more favorable conditions for the driver to work.
DETERMINANTS OF IMPROVING THE SYSTEM OF REGULATORY DOCUMENTATION OF EXECUTIVE AUTHORITIES OF CONSTITUENT ENTITIES OF THE RUSSIAN FEDERATION
Authors: Avdeeva Irina , Manchenko O.
Published: October 2020

A study of the regulatory documentation of the executive authority of the constituent entity of the Russian Federation in the field of forestry was carried out in order to identify the determinants of improving the regulatory documentation system. It is noted that the system of regulatory documentation of the executive body under review is represented by status, functional and official regulations. It is indicated that the body in the field of its activities in the provision of public services and the performance of public functions to exercise control (supervision) performs a significant number of interagency interactions. Moreover, these interactions do not rely on specific regulatory documents – administrative regulations for interagency cooperation. Such a lacunae in the system of administrative regulations of the body in question causes the imperfection, non-optimality of its work. It is shown that one of the most significant manifestations of this situation is the state of affairs in the field of cooperation with law enforcement agencies in the prompt identification of violators of forest legislation and timely recovery of damage from these violations. The system of this interaction does not have a proper regulatory document and is characterized by low efficiency. It is concluded that the regulation of interaction with law enforcement agencies is a determinant of improving the system of regulatory documentation of this body. In this regard, the relevance of the activities of the body in question in the field of formulating proposals for the development of regulations, and, possibly, their more than approved local testing as an experiment at the level of individual regions, was noted. It is proposed in order to establish the procedure for interaction between bodies exercising powers in the field of forest relations and law enforcement agencies in identifying, suppressing, investigating and solving crimes in the field of forest use, to develop a regulation for interaction at the regional level.
MONITORING FIRES IN THE TERRITORY OF FOREST FUND OF REGIONS OF THE RUSSIAN FEDERATION
Authors: Zinoveva Irina , Medvedev P.
Published: October 2020

This work is devoted to the consideration of the problems of reducing forest resources, which is largely associated with fires that occur in hard-to-reach areas and in areas with increased recreational load. In this regard, the creation of an effective fire detection system using various types of monitoring – ground, aviation, and space – is of particular relevance and importance. An important monitoring task is not only monitoring the fire situation, but also assessing the effects of fires. To determine the location of forest fires on the lands of the forest fund and other categories of lands, as well as to collect and store data, the Avialesohrana Federal State Budgetary Institution uses remote monitoring of the ISDM-Rosleskhoz system, which helps to quickly detect fires using satellites, record them, and compile information on foci and give them an assessment. According to the ISDM-Rosleskhoz data, a comparative analysis of the dynamics of the number of forest fires in the regions of the Russian Federation for 2017-2019 was carried out, as well as an analysis of the area of forest land covered by fires in 2015-2019, the results of which revealed a growing trend in the number of fires and their increase area. As a result, it was concluded that it is necessary to improve the system of remote monitoring of forest fires with the aim of preventing, timely detecting and preventing spread.
The Experimental Study of Cardiotoxic Effects of Lead Oxide Nanoparticles by Their Various Routes of Exposure
Authors: Minigalieva IA  , Sutunkova MP , Klinova SV , Solovyova SN , Privalova LI , Gurvich VB , Chernyshov IN , Ryabova YuV , Bushueva TV , Shur VYa , Shishkina EV , Katsnelson BA
Published: October 2020

Background: Lead oxide nanoparticles are emitted in the workplace air of copper smelters. They are also a by-product in many other metallurgical industries. Objectives: Adverse health effects of lead oxide nanoparticles (PbO-NPs) were assessed in vivo using various routes of exposure with special attention paid to particle cardiotoxicity. Materials and methods: The subacute inhalation experiments were conducted on outbred female rats exposed to the generated aerosol of PbO-NPs in the concentration of 1.30 ± 0.10 mg/m3, 4 hours a day during five consecutive days, using the Nose-Only Inhalation Exposure System. The study of subchronic exposure to PbO-NPs was conducted on male rats using intraperitoneal injections made thrice a week during six weeks (18 injections in total). Conclusions: Following both types of exposure to PbO-NPs, we observed changes in toxicological indices including those specific for lead including a decrease in hemoglobin counts, an increase in blood reticulocyte counts and urine concentrations of δ-aminolevulenic acid. The subacute inhalation exposure to PbO-NPs affected electrocardiographic findings in animals (an increase in amplitudes of P and T waves) while the subchronic intraperitoneal injections decreased blood pressure and changed biochemical indices of the cardiovascular system (decreased activity of the angiotensin-converting enzyme and the concentration of endodelin-1).
Demanda hospitalaria pediátrica en tiempos de COVID-19
Authors: Rizo Patron Emiliana , Padilla Justo , Tantaleán José A.
Published: October 2020

La pandemia del COVID-19 en el Perú está causando una presión inusual a nuestros recursos hospitalarios y de cuidados críticos. A medida que la infección progresa en la población, esperamos ver un alza en los casos severos y en la demanda de unidad de cuidados intensivos (UCI) donde la capacidad de camas puede ser excedida. A pesar de que usualmente el COVID-19 causa una enfermedad poco grave en los niños, debemos estar preparados para que el numero de casos pediátricos ocasionen una sobrecarga en la capacidad de recursos hospitalarios. En un escenario de un 25% de proporción de infección acumulada en la población, podremos ver aproximadamente 891 niños críticamente enfermos que requieren hospitalización en UCI. Proponemos algunas estrategias para enfrentar la escasez de recursos de cuidados intensivos que permitan asegurar la atención de niños vulnerables con condiciones agudas y condiciones complejas que siguen incidiendo en los tiempos de pandemia.
Endocarditis bacteriana por Staphylococcus hominis de válvula nativa en paciente hospitalizado con COVID-19. Reporte de caso
Authors: Vélez-Páez Jorge L. , López-Rondon Edgar F. , Jara-González Fernando E. , Castro-Reyes Evelyn E.
Published: October 2020

La enfermedad del COVID-19 presenta actualmente una gama de síntomas que van desde la presencia de síntomas clásicos de compromiso de las vías respiratorias altas y bajas hasta alteraciones sensitivas como anosmia o trastornos del gusto. Las trombosis valvulares cardíacas y la endocarditis subsecuente son presentaciones extremadamente raras y poco descritas de la infección por COVID-19. Presentamos el caso de un paciente positivo para virus SARS-Cov2, quien desarrolló una bacteriemia por Staphylococcus hominis y que, ante episodios febriles persistentes y posterior evaluación de diagnósticos diferenciales, se identificó el diagnóstico de endocarditis infecciosa en válvula aórtica nativa sana -mediante ecocardiografía-, la cual fue adquirida en el hospital.
La transición epidemiológica en el Perú: análisis de los registros de mortalidad del 2003 al 2016
Authors: Bernabé-Ortiz Antonio , Carrillo-Larco Rodrigo M.
Published: October 2020

Objetivo: describir los patrones de mortalidad existente en el Perú, tanto a nivel nacional como regional. Materiales y métodos: este es un análisis secundario realizado usando los registros nacionales de mortalidad desde el año 2003 al 2016. Se siguió la clasificación de la Carga Mundial de Enfermedad 2017 para agrupar las causas básicas de muerte en cinco grupos: no transmisibles, infecciosas, maternas y neonatales, nutricionales, y accidentes y lesiones. Se usó la prueba tau de Mann-Kendall para evaluar tendencias en las causas de muerte en el tiempo. Resultados: entre el 2003 y 2016, hubo un total de 1 295 290 muertes a nivel nacional, pero solo se analizaron 698 037 muertes. Para el año 2003, 63,9% de las muertes ocurridas fueron por enfermedades no transmisibles, el 16,9% por causas infecciosas, y 8,8% por accidentes y lesiones. Para el año 2016, el 83,6% de las muertes fueron debido a enfermedades no transmisibles (valor de p para tendencia < 0,001), mientras que 8,6% fueron por causas infecciosas (valor de p para tendencia < 0,001), y 5,4 % por accidentes ylesiones (valor de p para tendencia < 0,001). Similares resultados se encontraron al evaluar las tendencias por sexo y por regiones. Conclusiones: desde el 2003 al 2016, la proporción de muertes debido a enfermedades no transmisibles se incrementó en el Perú. Este hallazgo es válido tanto para varones como mujeres, así como para las 25 regiones del país, donde las enfermedades no transmisibles fueron la primera causa de muerte.
Lepra: sospecha diagnóstica en área no endémica. Serie de casos y revisión de la literatura
Authors: Mendez-Guerra Carolina , Montenegro-Idrogo Juan José , Resurrección-Delgado Cristhian , Quevedo-Ramírez Andrés , Cornejo-Venegas Gonzalo , Berrio-Martínez Sabja , Arévalo-Abanto Jorge , Chiappe-Gonzalez Alfredo
Published: October 2020

La lepra es una enfermedad crónica granulomatosa causada por el bacilo Mycobacterium Leprae que afecta piel y células de Schwann. En zonas no endémicas el diagnóstico de lepra suele ser dificultoso debido a la baja sospecha clínica. Durante el periodo de 2012 al 2019, se diagnosticaron y trataron tres casos de lepra en el servicio de infectología del Hospital Nacional Dos de Mayo. El tiempo de enfermedad promedio fue 4 años. Los pacientes iniciaron con pápulas pruriginosas en regiones corporales específicas, progresando a nódulos generalizados. Se constató parestesia e hipoestesia táctil, térmica, dolorosa y vibratoria; las cuales progresaron a anestesia. El diagnóstico se realizó mediante baciloscopía en secreción linfática y biopsia de nódulos cutáneos. Se describen las características clínicas de cada uno de los pacientes. Se remarca la importancia de la sospecha diagnóstica de esta entidad desatendida en áreas no endémicas.
Incorporating Paragraph Punch into EFL Writing Class
Authors: Burhanudin Asep
Published: October 2020

This study aims at revealing the implementation of the use of video in teaching speaking skill. It involves twenty nine junior high school students, one English teacher, and two college students. The research method of this study is classroom action research (Kemmis and McTaggart 1988, cited in Burns, 2010) using observation and interview as data collection techniques. The gained data are then analyzed qualitatively. Findings present that the use of video can be beneficial for the teacher in teaching speaking skill, especially for the aspect of pronunciation (Stempleski, 1990, further discussed in Richards and Renandya, 2002). The results indicated that the students show improvements in their pronunciation after learning by using the video. In addition, the students are very enthusiastic in learning speaking by using video. The students focus on watching the video and most of them raise their hands to answer teacher’s questions related to the video. As the video provides the motion pictures which is more interesting for the students, the students focus on watching and trying to understand the content of the video. Based on these findings, it is recommended for the teachers to use video in teaching speaking skill at any school levels in order to make the students understand the lesson easily.