bluuebunny/crossref_metadata_2025 huggingface dataset:
The paribhāṣās in the Śrautasūtras: Problems, Opportunities and Premises for an Investigation
Authors: Chierichetti Pietro
Published: August 2018

What is a paribhāṣā? How does it work in Śrautasūtra-texts? This paper tries to examine these questions and to trace a story of the paribhāṣās in the Śrautasūtras, giving some indications for future researches. Often translated as “meta-rule”, paribhāṣā is a primary derivative from the Sanskrit root “bhāṣ”, which means “to talk”, with the prefix “pari”, which means “around”, “beyond”. The term indicates a specific discourse “around” or “beyond” something. Therefore, it represents the link with the context, a hybrid element placed between text and context. A paribhāṣā is an explanation, an element around discourse that acts as a frame for what is said: it is a rule that is valid in a wider context than that of the object under analysis, that goes “beyond” discourse. It is a unique opportunity to glance at the ritual in itself, at the “ritual string”, in opposition to every “discourse of the ritual”. This rule’s validity is put into effect through the other rules expressed within the text, in other words it is a meta-rule. However, the subject of the relationship between paribhāṣās and the texts of the śruti is still uncharted territory: the categorizations that have so far been suggested are weak or not useful, and need stronger foundations. The present paper pretends to be a first step in this direction.
… And What about the Vedānta Paribhāṣā’s paribhāṣātva? Some hypotheses on the use of paribhāṣās in later Advaita Vedānta
Authors: Pellegrini Gianni
Published: August 2018

This contribution re-analyses some standpoints of the notion of paribhāṣā through the looking glass of later Advaita Vedānta. The article is limited to single text, namely Dharmarāja Adhvarīndra’s (17th–XVIIIth century) Vedānta Paribhāṣā. This text does not present the peculiarities of earlier paribhāṣās, hence the title paribhāṣā somehow assumes a sense closer to “Elucidation” or “Manual”. Nevertheless, placing Vedānta Paribhāṣā within a wider historical and philosophical milieu, an attempt is made to investigate the reasons why Dharmarāja willingly chooses such an evocative title, which is solidly rooted on a technical background. Further, the paper proposes some hypothesis and case-studies concerning Dharmarāja’s understanding of paribhāṣā.
Determination of the In Vitro Gas Production and Potential Feed Value of Olive, Mulberry and Sour Orange Tree Leaves
Authors: Olfaz Mustafa , Kilic Unal , Boga Mustafa , Abdi Abdiwali Mohamoud
Published: August 2018

This study was conducted to determine the potential nutritive value andin vitrogas production (IVGP) parameters ofOlea europaea L. (Olive = OL),Morus alba L. (Mulberry = ML) andCitrus aurantium L. (Sour orange = SOL) tree leaves. Hohenheim gas test was used to determine thein vitrogas productions of the leaves. The gas production of samples over time was recorded for 3, 6, 9, 12, 24, 48, 72 and 96 h after incubation. Completely Randomized Design was used to compare gas production, and gas production kinetics of samples. The findings of the present study suggested that there were differences among the tree leaves in terms of crude protein, NDF,in vitrogas productions, organic matter digestibility (OMD), metabolisable energy (ME), net energy lactation (NEL) and relative feed values (RFV) (P<0.01). ML had the highest condensed tannin contents (P<0.05),in vitrogas production (IVGP), OMD and energy values (P<0.01). SOL had highest RFV values. OL showed the lowest IVGP when compared to SOL and ML. Low NDF and ADF contents of SOL would probably increase the voluntary intake, digestibility and relative feed values of these leaves by ruminants. In conclusion, it was determined that OL, ML and SOL used in the study have lowin vitrogas production and can be utilized as alternative roughage feed in ruminants. However, it is recommended that the results obtained from this research should be tested inin vivostudies.
Shading by invasive seaweeds reduces photosynthesis of maerl from the Ría de Vigo (NW Spain)
Authors: Cobacho Sara P. , Navarro Luis , Pedrol Nuria , Sánchez José M.
Published: August 2018

The overgrowth and shading of several alien species along the European Atlantic coast are expected to reduce photosynthesis of maerl, decreasing its growth and fitness. In this work, three shade levels (0, 20 and 50%) were set up under laboratory conditions to simulate different competitive scenarios potentially affecting maerl beds. Live individuals of Sargassum muticum and Undaria pinnatifida were placed over maerl cultures, and the effects of shading were assessed by chlorophyll a fluorescence using a pulse-modulated fluorescence monitoring system. Photosystem II efficiency was measured as the ratio of variable to maximal fluorescence (Fv/Fm) as a proxy for the stress experienced by maerl. According to our data, irradiance reduction results in a small, yet significant, impact on the PSII efficiency of maerl, which could have fitness consequences.
Carbon nanomaterials based on interpolyelectrolyte complex lignosulfonate-chitosan
Authors: Brovko Olga , Palamarchuk Irina , Bogolitsyn Konstantin , Bogdanovich Nikolay , Ivakhnov Artem , Chukhchin Dmitriy , Khviuzova Kristina , Valchuk Natalia
Published: August 2018

A new approach to the formation of “fullerene-like” carbon-nitrogen carbogels based on the interpolyelectrolyte complex lignosulfonate-chitosan (IPEC LSNa-CT) was developed. It was established that carbogel maintained the morphology of the precursor complex, i.e. the spherical geometry and the particle size of its main fractions (40–55 nm) were stored in the carbonizate. The influence of pyrolysis (Py) temperature was studied in the range of 500–1000°C on the structure of carbonizate. Carbogels obtained under different processing conditions have a well-developed microporous structure. The specific surface area of carbogels reduced with increasing Py temperature according to their nitrogen content. The maximum specific surface area (438.3 m2 g−1) corresponds to the carbogel obtained at 600°C, while the maximum nitrogen content of this sample is 4.4%. The internal porosity of the material and the volume of supermicropores are reduced with increasing Py temperature due to the accumulation of double and triple carbon bonds in the carbogel. Apparently, the structure-forming N-atoms participate in the formation of condensed nitrogen-containing and cyclic structures as a donor of the electron pair and as such they accelerate the carbonization process.
Cutting forces and chip formation revisited based on orthogonal cutting of Scots pine
Authors: Zhu Zhaolong , Buck Dietrich , Ekevad Mats , Marklund Birger , Guo Xiaolei , Cao Pingxiang , Zhu Nanfeng
Published: August 2018

The objective of this study was to understand better the cutting forces and chip formation of Scots pine (Pinus sylvestris L.) with different moisture contents (MCs) and machined in different cutting directions. To that end, an orthogonal cutting experiment was designed, in which Scots pine was intermittently machined using a tungsten carbide tool to produce chips. The cutting forces were measured and the chip shapes were quantitatively described. Four conclusions can be drawn: (1) with increasing MC, the average cutting forces initially decreased and then stabilized, while the angle between the direction of the main and the resultant force continuously decreased. (2) The average cutting forces in the 90°–0° cutting direction were lower than the same forces in the 90°–90° cutting direction. (3) During machining, the dynamic cutting forces fluctuated less in the 90°–0° case. However, the dynamic feeding forces showed a decreasing trend in both the 90°–0° and the 90°–90° cases. (4) The process applied produced granule chips and flow chips, while less curly flow chips with a higher radius of curvature were more easily produced from samples with high MCs in the 90°–0° cutting direction.
Weakness and Mittag–Leffler Stability of Solutions for Time-Fractional Keller–Segel Models
Authors: Zhou Y. , Manimaran J. , Shangerganesh L. , Debbouche A.
Published: August 2018

We introduce a time-fractional Keller–Segel model with Dirichlet conditions on the boundary and Caputo fractional derivative for the time. The main result shows the existence theorem of the proposed model using the Faedo–Galerkin method with some compactness arguments. Moreover, we prove the Mittag–Leffler stability of solutions of the considered model.
Control of blood pressure and cardiovascular outcomes in type 2 diabetes
Authors: Vargas-Uricoechea Hernando , Cáceres-Acosta Manuel Felipe
Published: August 2018

High blood pressure in patients with diabetes mellitus results in a significant increase in the risk of cardiovascular events and mortality. The current evidence regarding the impact of intervention on blood pressure levels (in accordance with a specific threshold) is not particularly robust. Blood pressure control is more difficult to achieve in patients with diabetes than in non-diabetic patients, and requires using combination therapy in most patients. Different management guidelines recommend initiating pharmacological therapy with values >140/90 mm/Hg; however, an optimal cut point for this population has not been established. Based on the available evidence, it appears that blood pressure targets will probably have to be lower than <140/90mmHg, and that values approaching 130/80mmHg should be recommended. Initial treatment of hypertension in diabetes should include drug classes demonstrated to reduce cardiovascular events; i.e., angiotensin converting-enzyme inhibitors, angiotensin receptor blockers, diuretics, or dihydropyridine calcium channel blockers. The start of therapy must be individualized in accordance with the patient's baseline characteristics, and factors such as associated comorbidities, race, and age, inter alia.
Peak Power Output and Onset of Muscle Activation During High Pull Exercise
Authors: Barnes Matthew J. , Petterson Ashley , Cochrane Darryl J.
Published: August 2018

Barnes, MJ, Petterson, A, and Cochrane, DJ. Peak power output and onset of muscle activation during high pull exercise. J Strength Cond Res 35(3): 675–679, 2021—The aim of this study was to determine the percentage of 1 repetition maximum (1RM) at which peak power output occurred during the high pull (HP) exercise. In addition, the onset time of the biceps femoris (BF) and gluteus maximus (GM), across a range of loads, was investigated. Twelve resistance-trained men performed 1RM testing for the HP followed by lifts at 10% increments from 30 to 80% 1RM. During each load of power, output was measured using a linear potentiometer, whereas surface electromyography was recorded from the BF and GM. Peak power output occurred at 70% (1881.9 ± 296.1 W); however, there was no significant difference between loads at 60–80% (all p > 0.05). Loads between 40 and 80% 1RM produced significantly higher power outputs than 30% while 80% generated greater power than 100% 1RM (all p < 0.05). There was no significant (p > 0.05) main effect of muscle or load in the onset of BF (156.5–212.1 ms) or GM (112.1–158.1 ms). Therefore, these results suggest that training at a load between 60 and 80% 1RM may be useful in increasing power in the HP. In addition, activation of 2 of the hip extensors occurs in a relatively synchronous order irrespective of load.
Anthropometric and Physiological Characteristics of Elite Male Rugby Athletes
Authors: Brazier Jon , Antrobus Mark , Stebbings Georgina K. , Day Stephen H. , Callus Peter , Erskine Robert M. , Bennett Mark A. , Kilduff Liam P. , Williams Alun G.
Published: August 2018

Brazier, J, Antrobus, M, Stebbings, GK, Day, SH, Callus, P, Erskine, RM, Bennett, MA, Kilduff, LP, and Williams, AG. Anthropometric and physiological characteristics of elite male rugby athletes. J Strength Cond Res 34(6): 1790–1801, 2020—This is the first article to review the anthropometric and physiological characteristics required for elite rugby performance within both rugby union (RU) and rugby league (RL). Anthropometric characteristics such as height and body mass, and physiological characteristics such as speed and muscular strength, have previously been advocated as key discriminators of playing level within rugby. This review aimed to identify the key anthropometric and physiological properties required for elite performance in rugby, distinguishing between RU and RL, forwards and backs and competitive levels. There are differences between competitive standards such that, at the elite level, athletes are heaviest (RU forwards ∼111 kg, backs ∼93 kg; RL forwards ∼103 kg, backs ∼90 kg) with lowest % body fat (RU forwards ∼15%, backs ∼12%; RL forwards ∼14%, backs ∼11%), they have most fat-free mass and are strongest (back squat: RU forwards ∼176 kg, backs ∼157 kg; RL forwards ∼188 kg, backs ∼168 kg; bench press: RU forwards ∼131 kg, backs ∼118 kg; RL forwards ∼122 kg, backs ∼113 kg) and fastest (10 m: RU forwards ∼1.87 seconds, backs ∼1.77 seconds; 10 m: RL forwards ∼1.9 seconds, backs ∼1.83 seconds). We also have unpublished data that indicate contemporary RU athletes have less body fat and are stronger and faster than the published data suggest. Regardless, well-developed speed, agility, lower-body power, and strength characteristics are vital for elite performance, probably reflect both environmental (training, diet, etc.) and genetic factors, distinguish between competitive levels, and are therefore important determinants of elite status in rugby.
Neoliberalismo e Biopoder: o indivíduo como empresa de si mesmo / Neoliberalism and Biopower: individual as a self-entrepreneur
Authors: De Oliveira Robson , Sampaio Simone Sobral
Published: August 2018

O que esse artigo intenta demonstrar é que a constituição da ideologia neoliberal entrelaça formas de viver e processos de governamentalização apoiadas sobre as políticas sociais com a assunção de orientações para a gestão técnica da pobreza inspiradas pela lógica do mercado. O resultado disto é a produção de um indivíduo que se rende cada vez mais atomizado, seja quando visto como portador de capital humano e dependente de sua resiliência para superação da pobreza, seja quando tomado como empreendedor de si mesmo para tornar-se rentável e competitivo no mercado de trabalho. O que esse conjunto proporciona, ou explicita, é a vinculação indispensável entre neoliberalismo e biopoder na tessitura da sociedade capitalista contemporânea. As considerações finais identificam a fetichização da mercadoria força de trabalho, os efeitos das políticas sociais de orientação neoliberal e a necessária criação de outras formas de cooperação produtiva de classe-para-si para a classe trabalhadora.
Grandes Projetos Urbanísticos e Governança Urbana: análise do Programa Lagoas do Norte (PLN), em Teresina-PI / Great Urban Projects And Urban Governance: analysis of the Programa Lagoas do Norte (PLN), in Teresina-PI
Authors: Rodrigues Neto Edmundo Ximenes , Lima Antônia Jesuita
Published: August 2018

O presente artigo analisa o padrão de governança que orienta um grande projeto urbano em Teresina-PI, o Projeto Lagoas do Norte (PLN). Apoia-se em dados documentais (da Prefeitura Municipal de Teresina e da agência financiadora do projeto, o BIRD) e numa discussão teórica sobre governança urbana. O estudo constatou que os processos decisórios que consolidaram a estruturação da intervenção foram relativamente fechados, restritos ao governo municipal e ao BIRD. Constatou ainda que o caráter das instâncias e mecanismos de coordenação do programa se aproxima de um padrão gerencial com participação social, de perfil colaborativo, direcionada para a eficácia, sustentação e legitimação da intervenção.
Reestructuración de los Estados del Bienestar. Cambios cuantitativos y cualitativos: el caso de España / Restructuring of Welfare States. Quantitative and Qualitative Changes: the case of Spain
Authors: Gimeno José Adelantado
Published: August 2018

En este trabajo se examina el posible cambio de paradigma desde el Estado del Bienestar Protector hacia un Estado del Bienestar Inversor, tomando a España como estudio de caso. Metodológicamente se adopta un enfoque histórico-institucionalista sobre el cambio de paradigmas, y se aplican tres dimensiones de análisis: problemas a resolver, objetivos a conseguir y políticas a emplear. El principal resultado es que en España se ha producido un cambio cuantitativo que remercantiliza las condiciones de vida, y está en marcha una reorientación cualitativa que individualiza los riesgos y la protección social.
Serviço Social e Instituições Participativas: apontamentos sobre a atuação profissional no apoio ao controle social / Social Work and Participatory Institutions: presentation on professional activities in support of public control
Authors: Martins Ludson Rocha
Published: August 2018

O artigo busca ampliar a compreensão das bases de intervenção do Serviço Social nas instâncias de suporte ao controle social, a partir de indicações teórico-interventivas. Neste caminho é trabalhado o problema da mobilização social e da organização, a partir do debate nas ciências sociais e na profissão. Ao cabo, são realizadas algumas considerações práticas sobre o trabalho profissional nas instituições participativas.
O Fenômeno População em Situação de Rua Enquanto Fruto do Capitalismo / The Phenomenon Population in Street Situation as a Fruit of Capitalism
Authors: Tiengo Verônica Martins
Published: August 2018

Quem é a população em situação de rua? Como vive? Por que e como chegou às ruas? Quais são as suas principais características? Qual a importância do trabalho em sua vida? É fruto da preguiça ou do processo de acumulação capitalista? Neste artigo discutiremos essas questões. Situamos o fenômeno população em situação de rua em seu contexto estrutural, debatemos acerca de seu perfil e indicamos a intrínseca relação entre o modo de produção capitalista e a formação e ampliação da população em situação de rua enquanto parte integrante da superpopulação relativa.
A Importância da Linguagem e da Gestão da Informação nos Processos Participativos / The Importance of Language and Information Management in Participatory Processes
Authors: Prates Jane Cruz
Published: August 2018

Editorial
Killing in the Name
Authors: Richardson Peter , Pihlaja Stephen
Published: August 2018

While there has been an increase in the popularity of featuring negative portrayals of Islam and justifications of violence using the Qur'an, similar prominent contemporary interpretations of Biblical passages advocating and justifying violence have been largely ignored in Western discourse about religion and violence. This article focuses on justifications of the use of violence in the account of the fall of Jericho in Joshua chapter six, in which non-combatant adults and children are killed. Using Bamberg's (1997) framework for analysing how narratives position their characters, readers, and authors, it examines two contemporary interpretations from prominent Christians, William Lane Craig (2013, 2007) and John Lennox (2011). Findings show that both writers view the violence as just and necessary in the context provided by the Bible. However, the article also shows how such action could once again be perceived as right if believers combined these justifications with particular interpretations of New Testament texts while viewing themselves as entering a specific set of special circumstances.
Is there a difference between self-perceived performance and observed performance in an Objective Structured Clinical Examination (OSCE)? An exploratory study among medical students in the United Arab Emirates
Authors: Koornneef Erik , Loney Tom , Alsuwaidi Ahmed R. , Paulo Marilia Silva
Published: August 2018

This article was migrated. The article was not marked as recommended. Competency-based education and training has become a key component of healthcare systems across the globe. Ensuring that healthcare professionals are able to assess their own competencies is critical for continued professional development and the delivery of high-quality care. The aim of this study was to assess how medical students perceive their performance on an objective structured clinical examination. Using a cross-sectional study design, a sample of Emirati third and fourth year (preclinical) medical students (N=106; 56.4% response rate) was recruited from the United Arab Emirates University in Al Ain, United Arab Emirates. Medical students completed a short non-invasive clinical task (i.e. measuring and recording blood pressure and performing hand hygiene) followed by a structured survey to self-assess their performance and skills. Trained assessors used a clinical skills observation checklist tool to score each student's performance. According to the observed performance, 27.36% of medical students performed the objective structured clinical task adequately. In contrast, 69.52% rated their own performance as adequate. Furthermore, only 8.43% of medical students rated their own clinical skills as below average. This study did not find evidence that medical students can accurately assess their own clinical skills and performance. In order to support the delivery of high-quality healthcare, it is important that medical students develop their ability to accurately assess their own clinical skills and performance early in their medical careers. Teaching and appraising self-reflection is an important component of any undergraduate or postgraduate medical degree program.
Análisis del riesgo por inundación a causa del desborde de río Ilave, Distrito de Ilave – Collao
Authors: LOPEZ LUZ ENRÍQUEZ , MARON MOLLINEDO LOURDES , TACORA MARIACA SHADITH , QUISPE MAMANI ERICK JOSÉ
Published: August 2018

El presente estudio realizado muestra los riegos a los que se afronta una población, en caso ocurriese una inundación por intensas lluvias, lo cual viene consigo el objetivo de analizar el riesgo de  inundación por desborde del río Ilave en los siguientes barrios: Brisas del Río Blanco, Urbanización 24 de Junio y Barrio San Sebastián quienes vienen situados en las laderas de la afluencia del segundo río más caudaloso de la cuenca del Lago Titicaca, con una probabilidad de inundación por desborde del río a causa de lluvias torrenciales. La metodología empleada para este análisis consistió en la evaluación de los riesgos naturales, utilizando el manual del CENEPRED (Centro Nacional de Estimación, Prevención y Reducción del Riesgo de Desastres.), iniciando con la identificación de los factores condicionantes, desencadenantes y finalmente determinando el nivel de riesgo Muy Alto, Alto, Medio y Bajo respectivamente. Teniendo como resultado que el barrio Brisas del Río Blanco tiene un riesgo MUY ALTO, la Urbanización 24 de Junio alcanza un RIESGO ALTO y el Barrio San Sebastián adquiere un RIESGO MEDIO, concluyendo que,  lo más adecuado para su mitigación es la pronta adquisición de medidas de prevención, que puedan reducir el riesgo de inundación en el distrito de Ilave y evitar de esta manera un desastre que perjudique las actividades de dichos habitantes.
Asociación de cultivos, maíz y leguminosas para la conservación de la fertilidad del suelo
Authors: TORRES CALDERON SOLEDAD , HUARACA FERNANDEZ JHON , LAURA PEZO DEYSI , CRISÓSTOMO CALDERON RENZO
Published: August 2018

La pérdida de fertilidad y la erosión son los problemas más comunes de suelos a nivel mundial, en contraste a ello surgen tecnologías agroecológicas como la asociación de cultivos, que buscan alternativas para el manejo de enfermedades provocadas por plagas, la conservación de la biodiversidad y  de los recursos naturales y disminución del riesgo de pérdida de cosechas. Por ello, este artículo tiene como objetivo mostrar y analizar el intercalado de maíz con leguminosas con fines de manejo y  conservación de la fertilidad del suelo. Estudios llevados a cabo en varios países demostraron que la asociación de cultivos (policultivo) mejora la eficiencia biológica en comparación con los monocultivos tradicionales. La siembra de policultivos debe tener una distancia adecuada, en caso del maíz 0.9 m entre hileras por 0.4 m entre plantas, y de frijoles de 0.9m a 0,25 m, que permita que una de las especies libere compuestos alelopáticos que limite la aparición de malas hierbas. Por tanto, esta técnica agroecológica es una alternativa viable para el mejoramiento de la fertilidad de suelos, ya que el intercalado de maíz con leguminosas genera supresión de malezas, conservación de los nutrientes N, P, K del suelo y mejora el rendimiento de grano, incrementando así los beneficios ecológicos y económicos.
Does sickle cell trait reduce the frequency of spontaneous bleeds in severe haemophilia?
Authors: Ahmed Sagir G. , Ibrahim Umma A. , Kagu Modu B. , Abjah Usman A.
Published: August 2018

Haemophilia A is an X-linked recessive disorder associated with deficiency of coagulation factor VIII and lifelong bleeding diathesis. Sickle cell trait (SCT) is the heterozygous state for the sickle β-globin gene. The frequency of SCT is up to 30% in Africa, wherein it confers survival advantage by providing resistance against severe malaria. SCT does not cause vaso-occlusive crisis, but is associated with high risk of venous thromboembolism as variously reported in the literature. We consider SCT as a hypercoagulable prothrombotic state and hypothesise that coinheritance of SCT may ameliorate the clinical phenotype of severe haemophilia. We conducted a retrospective analysis of frequencies of spontaneous bleeding among severe haemophiliacs with SCT (Hb AS phenotype) and their counterparts with normal Hb phenotype (Hb AA phenotype) in order to determine the possible ameliorating effect of SCT on spontaneous bleeding rates in severe haemophilia A. If our hypothesis is correct, severe haemophiliacs with SCT will have lower frequencies of spontaneous bleeding than their counterparts with normal Hb phenotype. Our results revealed that severe haemophiliacs with normal Hb phenotype had significantly higher mean annual bleeding episodes per patient in comparison with their counterparts with SCT (45±7 vs 31±5, p=0.033), suggesting that severe haemophiliacs with SCT had lower frequencies of spontaneous bleeding episodes. The result of this study indicates that coinheritance of SCT in patients with severe haemophilia may be associated with reduced frequency of spontaneous bleeding, which may imply better overall prognosis. However, the study has important limitations, which include its retrospective nature and the very low number of subjects. The findings should therefore be validated by a larger and prospective study.
Experience of exercise in people with severe haemophilia: A qualitative study
Authors: Taylor Stephanie , Toye Francine , Barker Karen
Published: August 2018

The benefits of regular activity and exercise are well established, yet a third of the population of the European Union does not achieve the recommended levels of activity. For patients with haemophilia, some activity can cause bleeding into joints, leading to potential joint damage, whereas other activities can protect the joint from bleeds and further destruction. This study investigates the understanding and experience of exercise and activity in people with haemophilia (PWH). We conducted semi-structured interviews with six men with severe haemophilia using a consecutive sampling framework and Interpretative Phenomenological Analysis (IPA). We identified five themes: • “I don’t think about haemophilia, I’ve just got to deal with it” A level of acceptance of awareness of their condition, but they do not want it to rule their lives. • “I don’t let my limitations hold me back” Striving to find activities they can participate in, despite joint impairment. • ”The worst thing anyone can do is stop being active” Belief that activity helps to strengthen joints, gives confidence and improves both body and mind. • ”The best thing they did was to not wrap me up in cotton wool” Knowledge of haemophilia, how to treat and recognise bleeds, and finding activities to suit their bodies. • “Time constraints at home” Common barriers to exercise, as in the general population. Our findings provide clinicians with insight into understanding the barriers to exercise and activity in men with severe haemophilia. This can help clinicians to offer the most appropriate support and allow PWH to find an activity or exercise that suits them. Our findings demonstrate that even those with severe haemophilia wish to remain active and do not want to let their limitations prevent them from exercising. Findings also indicate that being given the education and freedom to make independent decisions about exercise and activities are valued. This suggests that clinicians need to provide a therapeutic environment where their patients can feel safe to make sensible choices about types and level of activity.
Aspire. Empowering professionals to lead Haemophilia care
Authors: Dodgson Sandra , Bryan Jenny , Fletcher Simon , Harrison Cathy , Ibbs Clare , Jones April , McLaughlin Paul , O’Brien Gráinne , Varney Sharon , Wareing Anne , Wick Pamela
Published: August 2018

Members of the multi-disciplinary team involved in delivering haemophilia care face a range of significant clinical and service leadership challenges. These include the developing treatment landscape, the drive towards individualised care, an uneven age structure among haemophilia nurses and constrained budgets. Faced with such challenges, the ASPIRE programme has been established to encourage and support a new generation of haemophilia leaders who are committed to improving haemophilia care across the UK, and beyond. The programme is open to healthcare professional from multiple disciplines, and is designed to support the development of a leadership community comprising members of the haemophilia care team in a way that contrasts with hierarchical leadership and management courses more typically found in the NHS.
Head injury in a haemophilia patient – Nursing considerations: a case report
Authors: Sulochana B. , Varghese Roseminu , Menon Girish
Published: August 2018

A person with haemophilia is at risk of intracranial haemorrhage caused by spontaneous or traumatic events, potentially resulting in long-term disability. Early initiation of timely treatment is essential to prevent this. In developing countries, morbidity and mortality is common in intracerebral haemorrhage (ICH) cases with haemophilia as a result of patients and family members having inadequate knowledge, lack of awareness regarding referral, lack of availability of treatment products, and delays in the treatment decision. These barriers can potentially be managed by the haemophilia nurse taking responsibility for the coordination of care. This case report addresses the nurse-coordinated care of a haemophilic patient with ICH in a developing country, and may provide insight into the benefits of a haemophilia nurse undertaking a coordinating role.
Haemostasis action of VELSEAL-T in a haemophilia A patient with external bleeding
Authors: Dutta Anupam , Das Anup Kumar
Published: August 2018

VELSEAL-Tis an innovative haemostatic medical device for the control of bleeding. Incorporating a clotting agent (thrombin) and anti-fibrinolytic agent (tranexamic acid), it enables rapid coagulation when blood flows into the dressing, leading to sealing and stabilisation of wound surfaces. A 36-year-old known to have mild haemophilia A presented with profuse bleeding from the forehead after injury following a fall on concrete surface. He attended hospital after 18 hours of injury as bleeding continued as soon as pressure was released from the injury site. A VELSEAL-T patch was applied to the injury site with the patient’s full consent. The bleeding stopped after 60 seconds, but the patient was instructed to hold the patch in place for a further 60 seconds. After two minutes of tight pressure application, there was no more oozing of blood from the injury site. This case shows that VELSEAL-T can be used as an aid in stopping external bleeding in haemophilia patients. Further trials should be undertaken to evaluate the safety and efficacy of this product.
Myocardial infarction in severe haemophilia
Authors: Bailly Jenique , Mahlangu Johnny
Published: August 2018

With improved replacement therapy, people with haemophilia (PWH) live longer, with the consequent emergence of age-related chronic diseases not previously seen in haemophilia. The prevalence of cardiovascular disease and associated complications in older PWH appears to be on the rise. Management of myocardial infarction in a person living with severe haemophilia presents a particular challenge, as treatment options often include antiplatelet therapy, anti-coagulation and invasive procedures. Current guidelines for managing acute myocardial infarction are not specifically designed for people with bleeding diatheses such as haemophilia. We present a patient with severe haemophilia A on extended half-life factor VIII prophylaxis who developed an acute ST-elevation myocardial infarction (STEMI), discuss his clinical management and highlight lessons learned.
Роль сорбционных явлений в распределении экстрактивных веществ между Glycyrrhizae radices и экстрагентом
Authors: Boyko N. N. , Makarevich N. A. , Pisarev D. I. , Zhilyakova E. T. , Novikov O. O.
Published: August 2018

В результате исследований установлено, что распределение экстрактивных веществ между фазами подчиняется сорбционным законам, при этом уравнение Фрейндлиха с достаточной точностью описывает процесс распределения экстрактивных веществ между фазами. Обнаружено, что на степень адсорбции экстрактивных веществ на матриксе Glycyrrhizae radices влияет способ измельчения сырья. Выяснено, что экстракционная система характеризуется тремя константами, которые описывают предельную степень адсорбции веществ на матриксе растительного сырья, концентрацию веществ в экстракте при достижении предельной степени адсорбции и энергетику процесса адсорбции / десорбции веществ.
Очистка хлорогеновых кислот методом твердофазной экстракции
Authors: Deineka V. I. , Mikheev A. Y. , Oleinits E. Y. , Deineka L. A.
Published: August 2018

Исследована возможность использования насадочных картриджей ДИАПАК С18 для очистки хлорогеновых кислот методом твердофазной экстракции. Показано, что особое внимание следует уделить сорбции 3-кофеоилхинной кислоты (3CQA), обладающей наименьшим удерживанием в условиях обращенно-фазовой хроматографии, а сорбцию необходимо проводить из подкисленных до рН 1 экстрактов. С учетом объема элюата, получаемого при десорбции, и последующего разбавления степень концентрирования 3CQA составит около 2.5, а для 5-кофеоилхинной и 4-кофеоилхинной кислот этот параметр может быть удвоен. Показано, что использование при пробоподготовке высоких концентраций метанола или ацетонитрила в качестве растворителей пробы может быть недопустимым из-за «выноса» части аналитов раньше основного пика.
Изучение термодинамики сорбции некоторых производных бензимидазола из водно-метанольных растворов на гексадецилсиликагеле
Authors: Yadrova A. A. , Pisareva V. S. , Shafigulin R. V. , Bulanova A. V.
Published: August 2018

В работе изучено влияние состава и природы элюента на удерживание биологически активных производных бензимидазола на гексадецилсиликагеле. В рамках модели Снайдера – Сочевинского рассмотрены зависимости фактора удерживания от структуры молекул. Оценены энергетические вклады различных заместителей в процесс сорбции, на основе разности изменений энергии Гиббса. На основании температурных зависимостей факторов удерживания исследуемых соединений рассчитаны энтальпия и энтропийная составляющая процесса сорбции.
Определение высоты слоя насадки при противоточном движении фаз в режиме идеального вытеснения
Authors: Ganin P. G. , Moshinskiy A. I. , Markova A. V. , Rubczova L. N. , Sorokin V. V.
Published: August 2018

Рассматривается проблема извлечения целевого компонента из газовой фазы в процессе противоточной абсорбции в режиме идеального вытеснения. Главное внимание уделено определению возможной высоты слоя, т.е. обратной задаче. Получены аналитические характеристики проблемы в критериальной форме. Даны рекомендации по выбору высоты слоя.
Выделение изоферментов сукцинатдегидрогеназы из листьев гороха методом ионообменной хроматографии
Authors: Fedorin D. N. , Eprintsev A. T.
Published: August 2018

Применение ионообменной хроматографии на колонке с ДЭАЭ-целлюлозой позволило получить высокоочищенные препараты сукцинатдегидрогеназы (СДГ, КФ 1.3.99.1) из листьев гороха с удельной активностью 1,665 Е/мг белка (для первой формы) и 0,445 Е/мг белка (для второй формы); выходом 22.48% и 14.99%. Степень очистки для изоферментов СДГ составила 79.29 и 21.19 раза соответственно. Показано, что полученные препараты сукцинатдегидрогеназы десорбировались с ДЭАЭ-целлюлозы при концентрациях хлорида калия 85 и 95 мМ, соответственно.
Влияние модификации порошкообразного хитозана на его аморфно-кристаллические и адсорбционно-порометрические характеристики
Authors: Sedelkin V. M. , Potekhina L. N. , Lebedeva O. A. , Ulyanova E. R.
Published: August 2018

Исследовано влияние различных способов модификации высокомолекулярного порошкообразного крабового хитозана, используемого в качестве сырья для получения адсорбентов, флокулянтов, пленочных материалов, разделительных мембран различного функционального назначения, на его аморфно-кристаллические и адсорбционно-порометрические характеристики.
Anti-VEGF Treatment in Chronic Persistent Diabetic Macular Oedema
Authors: Blinder Kevin J ,   The Retina Institute, St Louis, MO, US
Published: August 2018

We have seen the efficacy of anti-vascular endothelial growth factor (VEGF) therapy in the treatment of diabetic macular oedema (DMO) as demonstrated by the major clinical trials, but what do we do for those that respond poorly to the standard treatment regimen? Let’s discuss this issue and others as it pertains to the treatment of DMO.
Achieving Optimal K-Anonymity Parameters for Big Data
Authors: Al-Zobbi Mohammed Essa , Shahrestani Seyed , Ruan Chun
Published: August 2018

Datasets containing private and sensitive information are useful for data analytics. Data owners cautiously release such sensitive data using privacy-preserving publishing techniques. Personal re-identification possibility is much larger than ever before. For instance, social media has dramatically increased the exposure to privacy violation. One well-known technique of k-anonymity proposes a protection approach against privacy exposure. K-anonymity tends to find k equivalent number of data records. The chosen attributes are known as Quasi-identifiers. This approach may reduce the personal re-identification. However, this may lessen the usefulness of information gained. The value of k should be carefully determined, to compromise both security and information gained. Unfortunately, there is no any standard procedure to define the value of k. The problem of the optimal k-anonymization is NP-hard. In this paper, we propose a greedy-based heuristic approach that provides an optimal value for k. The approach evaluates the empirical risk concerning our Sensitivity-Based Anonymization method. Our approach is derived from the fine-grained access and business role anonymization for big data, which forms our framework.
Veladuras. El servicio doméstico de niñas y jóvenes en la narrativa judicial de los años sesenta en Córdoba, Argentina
Authors: Gentili Agostina
Published: August 2018

Resumen: A partir de fuentes judiciales, normativas, reglamentarias y televisivas, y conjugando operaciones de cuantificación, reducción de la escala de observación y contextualización, se analizan las mutaciones culturales experimentadas por las prácticas de colocación en el servicio doméstico y su particular vinculación con espacios de acogimiento y reclusión infantil y juvenil. Con la atención en el contenido y las formas del relato judicial, se argumenta que hacia los años sesenta del siglo xx las colocaciones adquieren el carácter de un componente residual de la cultura en el que ciertos espacios institucionales ocupaban un lugar crucial para hacerlas admisibles. Un ensayo de lectura en clave de larga duración que pone de relieve que el valor atribuido a la infancia en la Argentina contemporánea corrió el umbral de lo que podía ser dicho sin desterrar ese destino del horizonte de posibilidades de un segmento singular de la población infantil.
Direitos humanos e fundamentais na fronteira entre direito e economia: a eficiência das políticas públicas de saúde no Brasil
Authors: Silva Marco Aurélio Souza da
Published: August 2018

O artigo aborda a importância da interdisciplinaridade entre direito e economia na concretização dos direitos constitucionais relacionados às políticas públicas de saúde no Brasil. Nas relações entre direito e economia, procura-se demonstrar as diversas possibilidades de contribuições da análise econômica para a gestão dos recursos públicos, especialmente em relação ao papel da efciência noplanejamento dos gastos estatais, na eleição das prioridades de alocação de recursos e na realização de políticas públicas de saúde. Partindo do método dedutivo, o objetivo do estudo é examinar alguns aspectos relevantes da teoria da análise econômica do direito que se relacionam com as políticas públicas de saúde. O debate é enriquecido com dados estatísticos do Banco Mundial e do Tribunal de Contas da União sobre a efciência dos gastos com saúde e sua judicialização no Brasil. Conclui-se que os serviços públicos de saúde no país podem ser melhorados em quantidade e qualidade, desde que levados em consideração aspectos não apenas de efetividade, mas também de efciência.
Reputação digital no Facebook, sustentabilidade empresarial e o consumidor
Authors: Fidalgo Adriano Augusto
Published: August 2018

O presente estudo versa sobre a Reputação Digital no Facebook, Sustentabilidade Empresarial e o Consumidor. Buscou-se harmonizar o convívio de todas essas premissas de modo concomitantemente, já que todos têm importância e função social, inclusive embasados em princípios de ordem constitucional. Em Reputação Digital no Facebook se viram conceitos, enfrentou-se os imagináveis conﬂitos entre liberdade de expressão e vedação ao anonimato, a exposição de dispositivos legais de interesse do Marco Civil e a importância do CONAR. Em Sustentabilidade Empresarial se apresentou a importância da sustentabilidade das corporações, as ferramentas de Governança Corporativa, Compliance, Gestão de Riscos, Auditoria Jurídica e se ilustrou o direito ao esquecimento. Em sede de Consumidor, elencou-se alguns princípios de direito do consumidor, relatou-se incidentes de consumo, a importância dos sites de reclamação, explicitou-se a eticidade digital, observou-se os casos práticos e a atribuição de indenização pelos abusos da liberdade de expressão. Em conclusão, com alicerce no princípio da dignidade da pessoa humana, constatou-se que é possível a convivência de todos esses valores declinados, de modo sistêmico, e, em última instância, o Judiciário atuará para fulminar os abusos, quando a empresa for atacada indevidamente, no Facebook, com a mácula indevida de sua reputação digital, notadamente quando o consumidor incorrer em abuso de direito.
O papel do advogado na negociação na sociedade contemporânea
Authors: Jr Biela , Fernandes Glaucia Guisso
Published: August 2018

O presente artigo analisa o papel do advogado no procedimento de negociação no Estado Democrático de Direito, a partir do método de negociação de Harvard e da teoria da comunicação não--violenta, viabilizando a comunicação efcaz, desde o seu planejamento, execução, fnalização, incentivando a continuidade das relações humanas, mesmo após o término da negociação.
A análise de discurso e seus entre-meios: notas a sua história no Brasil
Authors: Orlandi Eni Puccinelli
Published: August 2018

Il s’agit dans ce texte de montrer la constitution de l’analyse de discours en tant que discipline qui présuppose la linguistique et son rapport aux sciences humaines et sociales, travaillant la notion d’entredeux. D’autre part en situant cette histoire dans le territoire scientifique brésilien nous montrons les rapports historiquement établis et politiquement signifiés de l’analyse de discours au Brésil et en France. Nous travaillons aussi sur les enjeux du rapport constitution/institutionalisation de l’analyse de discours en tant que discipline scientifique.
Series Representation of Power Function
Authors: Kolosov Petro
Published: August 2018

In this paper we discuss a problem of generalization of binomial distributed triangle, that is sequence A287326 in OEIS. The main property of A287326 that it returns a perfect cube n as sum of n-th row terms over k; 0 ≤ k ≤ n−1 or 1 ≤ k ≤ n, by means of its symmetry. In this paper we have derived a similar triangles in order to receive powers m = 5; 7 as row items sum and generalized obtained results in order to receive every odd-powered monomial n2m+1; m ≥ 0 as sum of row terms of corresponding triangle. In other words, in this manuscript are found and discussed the polynomials Dm(n,k) and Um(n,k), such that, when being summed up over k in some range with respect to m and n returns the monomial n2m+1.
Atomic Surface Segregation and Structural Characterization of PdPt Bimetallic Nanoparticles
Authors: Rodríguez-Proenza Carlos A. , Palomares-Báez Juan P. , Chávez-Rojo Marco A. , García-Ruiz Amado F. , Azanza-Ricardo Cristy L. , Santoveña-Uribe Alan , Luna-Bárcenas Gabriel , Rodríguez-López José L. , Esparza Rodrigo
Published: August 2018

Bimetallic nanoparticles are of interest since they lead to many interesting electrical, chemical, catalytic, and optical properties. They are particularly important in the field of catalysis since they show superior catalytic properties than their monometallic counterparts. The structures of bimetallic nanoparticles depend mainly on the synthesis conditions and the miscibility of the two components. In this work, PdPt alloyed-bimetallic nanoparticles (NPs) were synthesized through the polyol method, and characterized using spherical aberration (Cs) corrected scanning transmission electron microscopy (STEM). High-angle annular dark-field (HAADF)-STEM images of bimetallic nanoparticles were obtained. The contrast of images shows that nanoparticles have an alloy structure with an average size of 8.2 nm. Together with the characterization of nanoparticles, a systematic molecular dynamics simulations study, focused on the structural stability and atomic surface segregation trends in 923-atom PdPt alloyed-bimetallic NPs was carried out.
Roundtable: How do you like to do professional development?
Authors: Tiveron Karen , Savage Stephanie
Published: August 2018

For this issue, we asked readers how they prefer their pro-dev: face-to-face, online, conferences, journal clubs, or something else? As you can imagine, the answers indicate a little of everything. Enjoy!