bluuebunny/crossref_metadata_2025 huggingface dataset:
Peculiarities of mentalization that hamper consultations of patients with BPD
Authors: Sokolova E. , Ryzhov A.
Published: September 2022

Introduction

The uncertainty of COVID-pandemia, vital danger and disruptions in the habitual social contacts can be paralleled to the experiences of severe emotional stress and violence, usually found in the people with Borderline Personality Disorder. Both can be regarded as hampering the ability to categorize and express thoughts, feelings and experiences. The implementation of distant forms of psychological counseling may accentuate the mentalization deficiency.

Objectives

To develop a theoretical framework for an empirical typology of impairments of mentalization.

Methods

The model of consciousness proposed by L.S. Vygotsky was used for theoretical generalization of the levels of categorical structures of mentalization observed in previous empirical studies.

Results

The following structures were identified: (1) the syncretic type of mentalization with low differentiation and complexity of object representations, their negative affective tone, autistic, chaotically mutable motivation and low emotional investment in relationships were described in patients with schizotypal disorders; (2) the “complex” type, with literal, non-generalized, field-dependent and rigid, or unstable, representation of the self, others and relationships as a result of the “fusion” of cognitive representations with the current emotional states. Similar types of mentalization were previously described in people with BPD and self-harming behavior (Sokolova, Laisheva, 2017).

Conclusions

The ’syncretic’ and ’complex’ types of mentalization produce affective-cognitive distortions of the image of a psychotherapist, hamper the understanding of the conditional and metaphorical character of the therapeutic process, render difficult the de-traumatization of the unbearable experiences, and lessen the effectiveness of consultations of people with BPD.

Disclosure

No significant relationships.
THAT’S SO CRINGE: Exploring the Concept of Cringe or Vicarious Embarrassment and Social Pain
Authors: Jesus S. , Costa A. , Simões G. , Dias Dos Santos G. , Alcafache J. , Garrido P.
Published: September 2022

Introduction

The word cringe has suffered alterations in its colloquial application, with its most recent version, adopted by generation Z and millennials, as a response to embarrassment or social awkwardness by proxy. This odd emotion is interesting in that it translates a vicarious embarrassment which is elicited whenever one is in the presence of a social blunder, public failures and threats to another’s social integrity.

Objectives

The authors aim to explore the novel concept of cringe, briefly discussing what is currently known about the emotional response. A potential correlation between empathy and cringe is discussed as well as the hypothesis that certain psychiatric disorders such as personality disorder may demonstrate altered cringe responses.

Methods

The authors propose a non-systematized brief literature review on works most pertinent to the topic.

Results

Formal and structured studies into the concept of cringe are far and few between, however, the literature does demonstrate that, the neural pathways of how social closeness affects our experience of cringe are starting to be explored. The concept of cringe, has also been described as a vicarious social pain. Exploration into the empathy pathways and their abnormalities, may demonstrate the underlying construct of cringe. Lack of this feeling may be present in those with empathy alterations, such as is seen in antisocial personality disorder.

Conclusions

Cringe is an uncomfortable feeling that surges when in the presence of someone suffering socially. Understanding this oddity may permit further understanding of empathy pathways as well as exploring the neural abnormalities of those who do not feel cringe.

Disclosure

No significant relationships.
Understanding Generalized Anxiety: Contributions from Phenomenology and Philosophy
Authors: Gouveia P.A.
Published: September 2022

Introduction

Anxiety is an ambiguous term, meaning an emotional state, a clinical symptom, a disorder, or a group of disorders. Anxiety is a normal feeling that arises when a person believes he is in danger from a threat or unidentified danger, ensuing with a state of alertness, arousal, and exploratory attention. Its distinction from neighbouring concepts, such as anguish, fear, worry, anxiety, panic, or uneasiness, is valuable but controversial.

Objectives

Review and synthesize various contributions from phenomenology and philosophy to the understanding of what it is like to experience generalized anxiety.

Methods

Selective review of the most prominent literature regarding anxiety psychopathology, namely that of Jaspers, Heidegger, López-Ibor, Sims, Berrios, Femi Oyebode, Pio Abreu, James Aho, Picazo Zappino and Gerrit Glas.

Results

Jaspers described free-float anxiety as common and painful, floating and detached, as a feeling of misunderstood genesis, imposing despite the inapparent object, driving an inescapable need to provide some content to it, but also susceptible to insight by those who experience it. It can take a vitalized or primarily psychic form. Anxiety is closely related to the limits of the human being and to (hopelessness). For Heidegger, angst is the expression of authentic existence. López-Ibor considered anxiety and anguish nuances of the same experience, in both of which there is fear of the dissolution of the unity and continuity of the self (anguish). When what exists is not a fear, but only a threat, anxiety arises.

Conclusions

Phenomenologically informed psychopathology is relevant for clinicians. Complementing neurosciences, each answers questions that the other cannot.

Disclosure

No significant relationships.
Personalization of virtual reality for treatment of mental disorders by using a unified morphometric indicator
Authors: Moskvitina U.
Published: September 2022

Introduction

The search for approaches to creating a precision personalized virtual reality for the treatment of mental disorders is urgent. (Belkasim, 2005; Park M.J. et all., 2019).

Objectives

To develop a new approach to personalize the form of virtual reality content to the neurophysiological and anatomical parameters of the patient’s brain, to improve the quality of precision VR therapy for mental disorders.

Methods

The MRI study was carried out on a GE Optima 450w apparatus with a magnetic field induction of 1.5 Tesla. We used a radio frequency coil for the head. T1-weighted images were obtained with a field of view (FOV) of 24.4 x 14.8 cm and a slice thickness of 0.5 mm. Later, the images were built in three standard mutually perpendicular planes. Measurements were carried out using standard tools on an eFilm 4.0 WorkStation. FreeSurfer 4.5.0 was used to calculate the surface area of the cerebral hemispheres. To estimate the surface area of the room and the design of the shape in VR closed environment Autodesk AutoCAD 2018.

Results

A new approach to personalization of the form of virtual reality content has been developed (Patent No. RU (11) 2 668 697 (13) C1, 2018;Patent No. RU (11) 2 753 234 (13) C1, 2020). It is based on the use a single morphometric indicator for a closed VR space and brain.

Conclusions

Research and applied analysis of the developed approach is required. The development of this area will make it possible to create precision products for the therapy and rehabilitation of mental disorders.

Disclosure

No significant relationships.
Predicting Cardiovascular Disease in Psychiatric Patients: Machine Learning with Electronic Health Records
Authors: Bernstorff M. , Danielsen A. , Dinesen S.
Published: September 2022

Introduction

Cardiovascular disease (CVD) causes staggering losses in quality adjusted life years worldwide.1 Among patients in the Danish psychiatric hospital setting, heart disease is associated with a decrease in life expectancy of 5.1 years.2 The causes underlying this association are likely manifold. For example, severe mental illness is associated with unhealthy lifestyle.3 Furthermore, psychiatrists may focus predominantly on the treatment of mental illness and have less emphasis on detection and prevention of physical illness.4 If patients at elevated risk of CVD are pointed out automatically, this may lead to better preventive medicine.

Objectives

To predict which patients develop cardiovascular disease using machine learning.

Methods

We obtained data on all psychiatric hospital contacts in the Central Denmark Region since the initiation of the current EHR system (MidtEPJ). These span from 2011 to 2021 and cover 120,000 patients, of which 3,000 patients developed severe CVD (stroke or coronary event) follow-up. We will train a variety of models (random forests, SVM, deep neural nets) to predict CVD within one year from a planned contact to hospital.

Results

The modelling is currently underway, intermediary results are expected in January.

Conclusions

We explore whether predicting CVD is feasible using state-of-the-art technologies and a uniquely detailed dataset. This may pave the way for machine learning to act as a clinical support decision system, since we’re only training on data that is available in a live, clinical context.

References

1: Khan 2019

2: Erlangsen 2017

3: Scott 2011

4: Fagiolini 2009

Disclosure

No significant relationships.
Individual-specific changes in circadian rest-activity rhythm and sleep in symptom-free patients tapering their antidepressant medication
Authors: Minaeva O. , Schat E. , Ceulemans E. , Kunkels Y. , Smit A. , Wichers M. , Booij S. , Riese H.
Published: September 2022

Introduction

Group-level studies showed cross-sectional and prospective between-person associations between circadian rest-activity rhythms (RAR), physical activity (PA), sleep, and depressive symptoms. However, whether these associations replicate at the within-person level remains unclear. Therefore, it is clinically relevant to investigate these associations within persons and study whether changes in depressive symptoms are related to changes in circadian rhythm and sleep variables.

Objectives

To identify changes in circadian rhythm elements in proximity to a transition in depressive symptoms, whether changes are less frequent in individuals without compared to those with transitions, and whether there are individual differences in the direction of change of circadian rhythm variables.

Methods

Data of remitted individuals tapering antidepressants were used: 12 with and 14 without a transition in depressive symptoms. RAR, PA, and sleep variables were calculated as predictors from four months of actigraphy data. Transitions in depressive symptoms were based on weekly SCL-90 scores and evaluation interviews. Kernel Change Point analyses were used to detect change points (CPs) and CP timing in circadian rhythm variables for each individual separately.

Results

In 67% of individuals with depressive symptoms transitions, CPs were identified in proximity to symptom transitions. CPs were detected less frequently in the no-transition group with 7 CPs in 14 individuals, compared to transition groups with 10 CPs in 12 individuals. For several RAR and sleep variables, consistent changes were detected in expected directions.

Conclusions

Circadian rhythm variables provide potentially clinically relevant information although their patterns around transitions are highly person-specific. Future research is needed to disentangle which variables are predictive for which patients.

Disclosure

No significant relationships.
Duration of therapy and treatment compliance of depressive patients at clinical high-risk for psychosis
Authors: Omelchenko M.
Published: September 2022

Introduction

It is known that early withdrawal can lead to a worsening of mental health. This is particularly relevant for depressive patients with clinical high-risk for psychosis (CHR) for whom the recommended duration of treatment has not been established.

Objectives

Analyze the actual treatment duration of depressive patients at CHR after their discharge from hospital and compare it with the group of depressive patients without CHR.

Methods

A comparative study of 124 depressive patients with CHR and 27 depressive patients without CHR was conducted within a year after discharge from hospital to assess the therapy duration and treatment compliance.

Results

Within a year after discharge only 12.1% depressive patients with CHR and 29.6% ones without CHR continued to receive the therapy. The average duration of treatment after discharge was 7.4 months in the first group and 11.7 months in the second group. The majority of patients stopped treatment for the following reasons (in descending order of importance): lack of awareness of their mental condition (51.9% vs 40.3%), side effects (38.7% vs 11.1%), and negative attitudes towards the treatment on the part of patients’ immediate family members (8.9% vs 7.4%).

Conclusions

It has been found out that depressive patients with CHR are less likely to follow medical prescriptions than ones without CHR, they are more likely to have the lack of awareness of their mental condition, they are more likely to have side effects of the therapy. These findings require the development of a universal approach to the treatment of such patients after discharge from hospital.

Disclosure

No significant relationships.
Premorbid screening of healthy students may carry latent liability for schizophrenia or bipolar affective disorder with neurocognitive and neurophenomenological methods
Authors: Szendi Md Habil I. , Bagi A. , Szalóki S. , Hallgató E. , Domján N. , Kanka A. , Gál B. , Karcher É. , Pásztor H. , Jenei T. , Bóna O. , Kovács C. , Pejin A. , Daróczy J. , Diósi Á. , Pajkossy P. , Polner B. , Demeter G. , Racsmány M. , Baradits M. , Búzás A. , Dér A. , Gingl Z. , Gyimóthi T.
Published: September 2022

Introduction

This study was carried out to map psychosis spectrum disorder risk factors.

Objectives

Our goal was to find what kind of instrumental methods may help to detect latent liabilities for schizophrenia and bipolar affective disorder

Methods

Using online questionnaires n=710 students were screened. Groups were formed based on the inclusion criteria: N = 25 people prone to mood swings, N = 30 people prone to odd experiences and delusive thinking, and a normal control group with N = 30 people. Personality, temperament, self-experiences, affectivity scales, and cognitive screening were conducted in addition to actigraphy coupled with a mobile application for detecting subjective experiences (EMA). Furthermore, instrumental examination of self-agency, testing time interval discrimination and (re)production, eye-tracking, EEG-microstates, and laboratory testing of inflammatory, immunologic and cardio-metabolic measures of allostatic load were applied.

Results

Self-experience disorders: both risk groups showed significantly higher scores than the control group (CG). Self-agency: based on incorrectly attributed responses, the positive schizotypy risk factor (PSF) group differed from the CG (p = 0.003). Antisaccade study: the PSF group showed a difference from the CG (p = 0.002). Actigraphy: based on the distributions of diurnal cumulative activities, it distinguished those with a cyclothymic risk factor (CTF) from the CG (67% probability in the k-means clustering procedure).

Conclusions

Healthy students with a latent liability for schizotypy or bipolarity could be distinguished by some targeted laboratory methods. Susceptibility for bipolarity was indicated by actigraphic analyzes, and the risk for schizotypal development was indicated by deficiencies in the self-agency experience and by anti-saccadic eye movement disorders.

Disclosure

No significant relationships.
Dissemination project: Linking Clinical Practice and Research towards daily function and Mental Health prevention
Authors: Regev S. , Rosenblum S.
Published: September 2022

Introduction

Occupational therapy (OT) offers evidence-based methods to address daily functioning improvement and better health promotion. However, many adults who are dealing with deficient daily functioning due to unrecognized Attention Deficit Hyperactivity disorder (ADHD) do not benefit from these developed methods. Thus, they are at risk of experiencing adjustment barriers and poor mental health.

Objectives

The aim of this project is to develop a dissemination strategy in order to reach-out for this unrecognized ADHD population and grasp their attention in an early stage of life. The study following this project is measuring the possibility of this action to reach out to the individuals and make a small change in their daily functional capabilities.

Methods

The Laboratory for the Study of Complex Human Activity and Participation (CHAP) is a lab sited in the occupational therapy department at the University of Haifa. Its research address ADHD as part of further neuro-developmental challenges in the life span. The lab started a dissemination program including 4 OT researchers, and a group of former researchers for materials feedback.

Results

In the presentation we will share the dissemination strategy and it implementation during 6 months. Moreover, we will present a theoretically map relevant virtual pathways that adults with unrecognized ADHD may cross since childhood.

Conclusions

This preventative program towards health promotion aims to help people achieve meaningful milestones in life and live more fully. Moreover, this strategy may serve as a prototype for similar approaches in other outreach processes.

Disclosure

No significant relationships.
Predictive model of the risk of formation of mental deadaptation in chemical production workers
Authors: Kuzmina S. , Garipova R. , Mollaeva N.
Published: September 2022

Introduction

According to WHO, 30-50% of workers experience psychological stress, which contributes to the development of mental and psychosomatic disorders. It’s important to develop the problem of prenosological diagnosis and determination of criteria for the formation of mental maladaptation as predictors of mental disorders in relation to occupational risk factors. Mental disorders in workers in a dangerous environment are of the nature of prenosological, not clearly delineated by a circle of diagnostic symptoms.

Objectives

1st chemical factor in combination with noise and emotional stress, 2d chemical factor in combination with a threat to life (explosion and fire hazard), 3d working in conditions of noise and emotional stress

Methods

The influence of working environment conditions and non-production factors on the formation

Results

Predicting the development of mental mailadaptive state model was developed

Conclusions

Vegetative disorders are most likely to manifest in group 1, comorbid of which with obsessive-phobic disorders and depressive spectrum disorders. The group 2 is characterized by astheno-vegetative symptoms in correlation with the conversion type of response. In the third professional group, the nature of predictors is characterized by a pronounced isolation of groups of symptoms, the leading of which is the vegetative pattern.Vegetative syndroms are most likely to manifest in group 1, comorbid of which is obsessive-phobic disorders and depressive spectrum disorders. The group 2 is characterized by astheno-vegetative symptoms in correlation with the conversion type of response. In the third professional group, the nature of predictors is characterized by a pronounced isolation of groups of symptoms, the leading of which is the vegetative pattern.

Disclosure

No significant relationships.
The relationship between parental reflective functioning, attachment style, parental competence, and stress
Authors: Szabó B. , Miklósi M. , Futó J.
Published: September 2022

Introduction

Previous studies indicated, that mentalization mediates the link between adult attachment and stress, however, this relationship was not tested before among non-clinical parents of children aged between 12 and 18 years.

Objectives

The aim of this study was to explore the relationship between parental reflective functioning, attachment style, perceived parental sense of competence, and stress among parents.

Methods

After providing written consent, 186 non-clinical mothers completed a questionnaire packet that included a demographic form, The Parental Reflective Functioning Questionnaire - Adolescent version, the Attachment Style Questionnaire, the Parental Sense of Competence Scale, and the Perceived Stress Scale. A moderated mediation analysis with parental sense of competence as a dependent variable, mother’s attachment style as an independent variable, certainty about mental states hypermentalization subscale as a mediator, and stress as a moderator was conducted.

Results

In the moderated mediation analysis, the direct effect of the attachment style on the parental sense of competence in the case of preoccupied attachment style was significant (p < .001). The interaction term of the hypermentalization subscale by perceived stress was also significant in the case of low level (w = -1.57, p < .001) and high level of perceived stress (w= 1.21, p = .049) among mothers with a preoccupied attachment style.

Conclusions

These findings suggest that the preoccupied attachment style is related to the parental sense of competence through certainty about mental states hypermentalization in case of low level and high level of perceived stress, so mentalization-based interventions are warranted.

Disclosure

No significant relationships.
Prognostic competence as a criterion for the mental health of primary schoolchildren with psychological development disorders
Authors: Artemyeva T. , Mendelevich V. , Akhmetzyanova A.
Published: September 2022

Introduction

Younger schoolchildren with psychological development disorders have low cognitive activity, insufficient development of basic school skills, and a low level of educational motivation. In accordance with the requirements of the educational program for students with psychological development disorders, it is important to develop the ability to predict the results of their actions.

Objectives

The study of predictive competence in primary schoolchildren with psychological development disorders.

Methods

The study involved 60 children aged 8-10 years with a psychological development disorder. To study predictive competence, the methodology “The ability to predict in situations of potential or real violation of social norms” was used.

Results

The study revealed a low level of the cognitive and speech-communicative spheres of prognostic competence development in primary schoolchildren with psychological development disorders, as well as a deficit in prediction in the field of learning, which includes educational cooperation and educational communication of the child. Generalized statements, a passive position in future situations and pessimistic attitudes prevailed in the predictions of schoolchildren when constructing an image of the future. For schoolchildren with psychological development disorders, the prognosis is presented by monosyllabic answers, with the observable poverty of speech utterances.

Conclusions

The features of prognostic competence revealed in the study make it possible to develop individual programs for the development of the prognostic abilities of schoolchildren with psychological development disorders. This paper has been supported by the Kazan Federal University Strategic Academic Leadership Program.

Disclosure

No significant relationships.
ProTransition – evaluation of an online-course for professionals to optimize the health care service for young people with mental illness in transition from adolescence to adulthood
Authors: Koenig E. , Reetz S. , Hoffmann U. , Fegert J.M.
Published: September 2022

Introduction

Adolescent transitions to adulthood are a vulnerable phase for the development of mental illnesses. Additionally, there are often disruptions in psychiatric care delivery during the transition phase, potentially leading to a considerable treatment delay with a high risk of early chronification. Thus, the health care system and professionals in both child and adolescent psychiatry and adult psychiatry should give greater consideration to the transition phase.

Objectives

An online-course addressing health care professionals was developed to give in-depth knowledge of “transition psychiatry”, practical guidance and to sensitize for the special challenges and needs of young adults with mental illness. Evaluation focuses on the gain of competences, benefit for practical work and user satisfaction.

Methods

Participants´ estimations and opinions on quality of the online-course, on impact of course participation to their practical work and on their competences regarding transition psychiatry are assessed with an online-survey before starting (t1) and after finishing (t2) the online-course. T1-assessment is already completed with 1924 datasets, t2-assessmend will take place 02/2022.

Results

Analyses of t1-assessment show a high heterogeneity of participants regarding their work background and setting. Special knowledge about mental illnesses during transition and about transition psychiatry, as well as feeling confident in accompanying transition processes is on a medium level. Results of t2-assessment and comparing analyses are expected in March 2022 and will be presented.

Conclusions

There was high interest of the target group in participating in the online-course. Evaluation will show if the online-course is a helpful measure in delievering the necessary education of professionals in transition psychiatry.

Disclosure

No significant relationships.
Association Between Workplace Bullying Occurrence and post-traumatic stress disorder Among Healthcare Professionals in Tunisia
Authors: Mnif M. , Smaoui N. , Omri S. , Feki R. , Gassara I. , Maalej M. , Ben Thabet J. , Zouari L. , Charfi N. , Maalej M.
Published: September 2022

Introduction

Nurses may be particularly at risk of violence exposure at work which can cause psychological trauma and even develop post-traumatic stress disorder (PTSD), which is a serious mental health disorder.

Objectives

The aim of this study was to determine the prevalence of PTSD among nurses in psychiatry and emergency departments and to identify the factors associated with it.

Methods

This was a cross-sectional, descriptive and analytical study. It concerned 60 nurses working in the psychiatry (35 nurses) and emergency (25 nurses) departments of the Hedi Chaker and Habib Borguiba University Hospital in Sfax. The screening of PTSD was carried out by the « post-traumatic stress evaluation questionnaire » (PTSQ).

Results

Direct trauma exposure was reported by 93% of participants, of which 48.3% experienced the act of violence more than 4 times. According to the PTSQ, 48.3% of the nurses had PTSD with a mean score of 50.93. Hyper-arousal was the most frequently observed outcome in victims (85%), followed by re-experience (83%) and avoidance (80%) symptoms. The presence of PTSD was correlated with female gender (p=0.002), the young age of the nurse (p=0.04), and the absence of peri-traumatic reactions (p=0.001).

Conclusions

Our study shows that PTSD is a pathology frequently encountered in psychiatric and emergency nurses. Hence the need to put in place strategies against violence in hospitals and to apply them rigorously in order to better manage this phenomenon and manage its repercussions on health workers .

Disclosure

No significant relationships.
Identification of violence in the hospital environment: perceptions of nurses
Authors: Mnif M. , Smaoui N. , Feki R. , Gassara I. , Omri S. , Charfi N. , Ben Thabet J. , Zouari L. , Maalej M. , Maalej M.
Published: September 2022

Introduction

Violence is recognised by the WHO as a major and ubiquitous public health problem, that is constantly worsening.

Objectives

The aim of our work was to estimate the frequency of aggressions against nurses in psychiatric and emergency departments, and to identify the factors associated with it.

Methods

This was a cross-sectional, descriptive and analytical study. It took place between January and March 2021, at both hospitals of Sfax (Tunisia).This study targeted 60 nurses in the psychiatry and emergency services.

Results

The sample comprises 35 nurses (58%) from psychiatric services and 25 nurses (42%) from emergency services, mainly females (51%) and with average age of 35 years.(+/-9). The nurses interviewed were exposed to violence quite often, in 93% of cases. Almost all nurses (90 %) experienced verbal violence, 70 % experienced physical violence and more than half (62 %) experienced psychological violence. Nearly 11% of nurses reported a sexual violence. Factors that explain or contribute to violence mentioned by the participants were as follows; The Verbal violence was significantly correlated with poor reception conditions (p=0.013). The Sexual violence was significantly correlated with young age of nurse (p=0.005). As for psychological violence, it was significantly correlated with work overload (p=0.004), a poor caregiver-patient relationship (p=0.02) and poor patient care (p=0.04).

Conclusions

Our study showed that violence against nurses was frequent in psychiatric and emergency departments. Various factors could modulate their occurrence such as training and improvement of the working conditions.

Disclosure

No significant relationships.
Immune regulatory gene polymorphisms, frequent cannabis use, and psychosis: implications to Treg hypofunction
Authors: Corsi-Zuelli F. , Loureiro C. , Shuhama R. , Quattrone D. , Deakin B. , Menezes P. , Lacchini R. , Coeli-Lacchini F. , Louzada-Junior P. , Del-Ben C.
Published: September 2022

Introduction

We have previously shown that the association between frequent cannabis use and psychosis is more likely in subgroups with low-grade inflammation than subgroups without (PMID: 33736715). The role of immune-related polymorphisms remains unknown.

Objectives

To explore whether polymorphisms affecting the function of key immune regulatory proteins moderate the association between cannabis and psychosis, namely: ENTPD1 and NT5E, involved in the synthesis of CD39, CD73, respectively, and anti-inflammatory adenosine; CTLA4 and
FOXP1,
essential for Treg functional capacity.

Methods

We genotyped blood samples from 283 community-based controls and 140 recent-onset psychosis patients in Brazil (EU-GEI consortium, Ribeirão Preto/SP) for twelve polymorphisms (ENTPD1: rs3814159, rs3176891, rs10748643; NT5E: rs9444348, rs2295890; CTLA4: rs3087243, rs231775, rs5742909, rs4553808; FOXP1: rs6803008, rs6786408, rs830599; Illumina Human Core Exome-24). Cannabis frequency (daily, less than daily, never) was assessed by self-report (Cannabis Experience Questionnaire). Binary logistic regression models (OR,95%CI) included case status as the outcome, genotype (dominant model), cannabis frequency, and an interaction term between the two as exposure, adjusting for confounders (age, sex, ethnicity, tobacco smoking).

Results

We found significant interactions between cannabis use and polymorphisms for ENTPD1 (rs3814159), NT5E (rs9444348), and FOXP1 (rs6786408). Less than daily or daily use were, in a dose-response fashion, only associated with psychosis in those with the variant and heterozygous genotypes; less than daily: ENTPD1 AG/GG (3.34,1.71-6.50); NT5E AG/AA (3.71,1.87-7.33); FOXP1 AC/CC (2.98,1.54-5.77); daily: ENTPD1 AG/GG (16.81;5.89-47.96); NT5E AG/AA (21.20,6.81-66.01); FOXP1 AC/CC (13.75,5.22-36.21).

Conclusions

Variation in genes that affect Treg function appears to modify the effect of cannabis consumption on psychosis in keeping with Treg hypofunction hypothesis (PMID:33713699).

Disclosure

No significant relationships.
Using fNIRS to study Mother-Child Brain-to-Brain Synchrony in Typical and Atypical Contexts
Authors: Esposito G.
Published: September 2022

A potential avenue of investigating the caregiver-infant relationship lies in caregiver-infant synchrony, which refers to the coordinated interplay of behavioural and physiological signals reflecting the bi-directional attunement of one individual to the other’s psychophysiological, cognitive, emotional and behavioural state. Here, we aim to study how early naturalistic caregiver-infant interactions give raise to caregiver-infant attachment, which influences physiological and psychological processes by modulating brain sensitivity. Furthermore, we aim to study how caregiver-infant bond shapes neural pathways involved in socio-emotional regulation in typical and atypical contexts. We present new evidence from fNIRS hyperscanning studies, where we measured simultaneous caregiver (mothers, N=30 and fathers N=38) and child brain activity (N=70). From the mother-child hyperscanning study (Azhari et al., 2019; 2020; 2021), we have found that higher levels of parenting stress are correlated to lower mother-child brain-to-brain synchrony, especially in the areas of the medial left prefrontal cortex. Additionally, maternal anxious attachment (Azhari et al., 2020a) also correlated in lower mother-child synchrony in the frontal and medial left prefrontal regions. These areas contain structures implicated in the inference of mental states and social cognition, highlighting the role of psychological factors such as parenting stress and attachment style in the influence of caregiver-infant bond formation during naturalistic interactions. From the combined mother- and father-child free play sessions (Azhari et al., 2020b), behavioural data revealed that parenting stress and caregivers’ recall of their past bonding experiences their own parents interact with each other to influence the eventual quality of dyadic interaction with their child.

Disclosure

No significant relationships.
Shame and psychopathology. Its role in the genesis and perpetuation of different disorders
Authors: Azevedo F. , André R. , Quintão A. , Jeremias D. , Almeida C.
Published: September 2022

Introduction

Shame is a profound negative emotion that can sometimes be cover up by guilt and remain undiagnosed. Shame and guilt have been described as self-conscious and moral emotions as they both involve self-evaluation and lay a role in facilitating moral conduct. They derive from the notion of responsibility, but some authors suggest that while guilt focuses only on the act at hand shame focuses on the one executing it. The self is the object.

Objectives

To review the literature on shame and its role in different disorders both as a causing agent and as a perpetuating agent

Methods

Non-systematic review of the literature with selection of scientific articles published in the past 20 years; by searching Pubmed and Medscape databases using the combination of MeSH descriptors. The following MeSH terms were used: “shame”, “psychopathology.

Results

Since shame globally decreases self-esteem and is an awareness of personal flaws it can lead to the feelings of helplessness and the development or worsening of mental disorders. As such it is no wonder to find shame being studied in many different forms, more and less structured with important connections being made with social anxiety, eating disorders, dysmorphic disorders, personality disorders and bereavement.

Conclusions

Shame’s role, independently from guilt can have an impact on both the genesis and perpetuation of mental disorders. Its study can uncover missing links between different types of experiences and the pathological reactions that may subsequently follow.

Disclosure

No significant relationships.
Early Maladaptives Schemas among call center staff in the Rabat Sale Kenitra region, Morocco
Authors: Drissi E. , Boulbaroud S. , Hami H. , Ahami A.O.T. , Azzaoui F.Z.
Published: September 2022

Introduction

It is important to know the prevalence of the Early Maladaptives Schemas (EMS) in such population.

Objectives

The study of Early Maladaptives Schemas among call center staff in the Rabat Sale Kenitra region and possible socio-economics factors that may influence them.

Methods

The study involved 121 call center’s employees in the Rabat Sale Kenitra region. They responded to an informative questionnaire and to the SPI 26, with 26 items, including 13 early maladaptives schemas.

Results

121 subjects were interviewed, 48.78% (n=59) men and 51.24% (n=62) women, a minimum age of 22 years, a maximum age of 60 years and an average of 31.74 7.93. Through the examination of the EMS’s results in adulthood, we note a decreasing ranking of active shemas according to the rate of participants: the EMS Unrelenting standards is active in 80.02% of our sample, the EMS Mistrust in 61,2%, the EMS Insufficient self-control in 47.9%, the EMS Abandonment in 47.1%, the EMS Insufficient self-control in 41.3%, the EMS Emotional inhibition in 38.8%, the EMS Vulnerability to harm or illness in 33.1%, the EMS Dependence in 31.4%, the EMS Selfsacrifice in 27,3%, the EMS Social Isolation in 19%, the EMS Emotional deprivation in 10.7%, the EMS failure in 8.3% and the EMS Enmeshment in 7,4%.

Conclusions

By comparing the rates of EMS in childhood and adulthood, it emerges that only the EMS Abandonment, Dependence and Insufficient self-control showed a disinensification, increasing successively from adulthood to childhood as follow :from 69.4% to 47.1% , from 52,9% to 31.4% and from 59.5% to 47.9%.

Disclosure

No significant relationships.
The phenomenology of motivation
Authors: André R. , Romão J. , Azevedo F. , Gonçalves M. , Sereijo C. , Saraiva R. , Croca M. , Abreu M.
Published: September 2022

Introduction

The concept of motivation pervades our professional and personal lives. Motivation is almost impossible to be observed directly, it is a construct for the interpretation of a behaviour that “calls the attention”.

Objectives

This work reviews the current available data on the phenomenological description of motivation and the abnormalities of motivation.

Methods

Non-systematic review of the literature with selection of scientific articles published in the past 10 years; by searching Pubmed and Medscape databases using the combination of MeSH descriptors. The following MeSH terms were used: “motivation”, “psychopathology”, “phenomenology”.

Results

Abnormalities in motivation may involve diminution or exacerbation. Anhedonia is the absence of pleasure in relation to usually pleasurable activities, it occurs in depression and schizophrenia where the pleasurable intrinsic motivation that acts as incentive for behaviour may be lost. In mania it may be increased so that mundane activities become unduly fascinating and rewarding.

Conclusions

Countless theories have been proposed to explain human motivation but each sheds light on specific aspects of motivation, neglecting others. This diversity creates confusion because most theories have areas of conceptual overlap and disagreement. To facilitate the development of studies, an agreement should be achieved on an operational definition of motivation.

Disclosure

No significant relationships.
Imagery and perception: where is the phenomenological line?
Authors: Simões G. , Jesus S. , Silva R.
Published: September 2022

Introduction

The overlap between imagery and perception has long fascinated philosophers and scientists. Many scientists considered how the mind is capable of constructing an internal world without intervention of the external environment. Descriptions of their core characteristics often draw attention to differential features, but other currents reveal that many of these are shared rather than unique and differential.

Objectives

The authors aim to analyse and discuss conceptualisation, similarities and differences of imagery and perception at the level of phenomenology, at the intersection with other psychopathological concepts, and thus reassemble them within a common framework.

Methods

A brief literature review was developed based on relevant works containing subject matter most relevant to the topic.

Results

Perception is conceived as a transformation of raw sensory stimuli into sensory information that is then decoded into meaningful at the cortical level. Imagery, in turn, corresponds to the internal mental representation of the world, actively drawn from memory. The differentiation between these concepts at a phenomenological level is analysed and discussed. Additionally, their individual role is evaluated in the pshycopathological expression of alterations of perception such as hallucinations, pseudohallucinations, pareidolic illusions, abnormal imagery, sensory deprivation and also of dreams, in an analytical perspective of integration and simultaneous conceptual differentiation.

Conclusions

Understanding imagery, its nature and formal characteristics is required for better recognising the nature of perceptions and related psychopathological alterations, as well as the mechanisms uniting these concepts. Further research is needed as these entities represent features of useful clinical and diagnostic significance.

Disclosure

No significant relationships.
Ischemic colitis induced by psychotropics drugs: a case report
Authors: Alvarez Garcia C. , Sanz Giancola A. , Nocete Navarro L.
Published: September 2022

Introduction

Ischemic colitis (IC) is a rare condition due to hypoperfusion in the large intestine. Usually the etiology is unidentified, but many drugs are known to induce it because of their anticholinergic effects. We present the case of a 63-year-old woman, with the diagnosis of histrionic personality disorder, in treatment with quetiapine and venlafaxine. She attended the hospital due to diffuse abdominal pain, diarrhea and hematochezia in the last two days. An abdominal CT scan is made, showing parietal thickening and submucosal edema in the colon, without any tumoral findings, suggesting IC.

Objectives

To point up the correlation between IC and the intake of psychotropic drugs.

Methods

We conducted a narrative review of the literature through the presentation of a case. Articles were selected based on their clinical relevance.

Results

There are reported cases of IC related to antipsychotics, but any drug with anticholinergic effects can potentially cause it. Anticholinergics reduce intestinal motility, leading to colonic ileus and dilatation. Both quetiapine and venlafaxine, taken by the patient, have these effects. Common obstructive and non-obstructive processes are excluded due to the absence of any other pathological signs. For these reasons, the diagnosis of IC secondary to treatment with quetiapine and venlafaxine is made.

Conclusions

Many psychotropic drugs can produce IC owing to their anticholinergic effects, being this chance increased when taken simultaneously with other drugs with same effects. IC is a rare but fatal side effect, which makes it important to consider it in the differential diagnosis in patients in treatment with psychotropics who suffer from gastrointestinal symptoms.

Disclosure

No significant relationships.
Malignant catatonia due to clozapine withdrawal: A case report and a brief review of the literature
Authors: Regueiro Martín-Albo C. , Mayor Sanabria F. , Fernández Fariña M. , Expósito Durán M.E. , García Recio A.
Published: September 2022

Introduction

Withdrawal symptoms are common upon discontinuation of many psychotropic drugs. Catatonia, a neuropsychiatric condition characterized by a number of motor, behavioral, emotional, and autonomic abnormalities, has been described as a withdrawal syndrome in a growing number of case reports, but it is not well recognized. Treatment of catatonia usually includes benzodiazepines and electroconvulsive therapy. Standard consensus states that the use of neuroleptics should be avoided, as they are thought to worsen catatonia.

Objectives

With this case report, we attempt to contribute to the finding in literature that the withdrawal of clozapine may be associated with catatonia, and how reintroduction of clozapine could be indicated for its treatment.

Methods

A clinical case is presented of a 37-year-old female with a history of schizophrenia, presenting with altered mental status and new onset of catatonic signs and symptoms in the setting of a 7-day emetic syndrome. The possibility that vomiting prevented proper absorption of clozapine is postulated, causing the patient to present clinical features compatible with malignant catatonia.

Results

The patient required treatment with benzodiazepines, electroconvulsive therapy and clozapine re-initiation, leading to improvement of catatonic symptoms within a few days.

Conclusions

This case serves as a reminder to consider alternative diagnostic hypotheses in cases of catatonic syndrome unresponsive to standard treatments. When the clinical suspicion of drug withdrawal is high, restarting the discontinued medication, even an antipsychotic agent, may be indicated.

Disclosure

No significant relationships.
Amisulpride-induced late-onset rabbit syndrome: Case report and literature review
Authors: Gundogmus I. , Tekin S. , Tasdelen Kul A. , Uzun Ö. , Ozmenler K.N.
Published: September 2022

Introduction

Amisulpride is an atypical antipsychotic. Rabbit syndrome(RS) may be seen after antipsychotics use a few days or long‐term application. RS occurs after more frequent typical antipsychotics and also in rare cases atypical antipsychotics.Its characterized by the involuntary rhythmic movements of the lips however involves no tongue movements.

Objectives

Case report and reflection on its etiology

Methods

Case report and literature review

Results

A 28-year-old female with a diagnosis of schizophrenia applied with the complaints and symptoms of withdrawal, do not want to leave the house, physical anergy and avolition that started after stopped taking her medications. She was admitted to the psychiatry service and amisulpride treatment was started and was gradually increased to 800 mg/day. After 30 days of hospitalization, the patient was discharged with mild recovery. 14 days after the discharge, because of the abnormal involuntary movements in mouth, the patient applied. In clinical examination without tounge involvement, rhythmic motions were observed in the lips and jaw.Neurological examination, labrotory tests and cranial screening were all normal. She was evaluated by a private psychiatrist and was diagnosed with RS. Amisulpride treatment changed to olanzapine treatment with 15 mg/day. After two months, RS spontaneously regressed.

Conclusions

The resolution of the involuntary movements following discontinuation of amisulpride in our case, supported the diagnosis of RS. Although the mechanism by which RS emerges as a side‐effect of amisulpride is not fully understood, the drug’s high affinity for and selective binding to dopaminergic D2 and D3 receptors are thought to be responsible for this involuntary motion disorder.

Disclosure

No significant relationships.