bluuebunny/crossref_metadata_2025 huggingface dataset:
Autosomal dominant polycystic kidney disease (ADPKD) with multiple complications: Management challenges
Authors: Djajapranata Kenneth M. , Tjempakasari Artaria
Published: February 2024

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary polycystic kidney disease characterized by renal enlargement, resulting in renal failure. In Indonesia, the exact prevalence of ADPKD is unknown due to limited reports on the disease. The aim of this study was to report a case of a patient with ADPKD with multiple complications. A 54-year-old male presented to the emergency room of Dr. Soetomo Academic General Hospital, Surabaya, Indonesia, with a chief complaint of dark-red-colored urine for one week. There was a progressive abdominal enlargement over the past five years, which had become more tense and rigid for the past one month. The patient had a history of fatigue and hypertension with routine follow-up. Physical examination on admission showed normal vital signs, and the abdominal assessment revealed a palpable hard mass approximately 4 cm in size in the right upper abdomen. Laboratory test indicated anemia, leukocytosis, lymphopenia, proteinuria, hematuria, leukocyturia, and elevated serum creatinine and urea levels. Abdominal imaging using ultrasonography, computed tomography (CT) scan, and magnetic resonance imaging (MRI) revealed bilateral kidney and liver enlargement containing multiple cysts, suggesting polycystic kidney and liver disease. There was a ruptured cyst in the middle of the left kidney pole with minimal ascites found in the CT scan. The MRI exhibited the presence of multiple cysts in both kidneys, partially filled with blood. The patient was diagnosed with ADPKD, gross hematuria, acute or chronic kidney disease (CKD), urinary tract infection (UTI), normochromic-normocytic anemia, and metabolic acidosis. Dietary control with high-calorie, high-protein, and low-salt diet; fluid balance; and other symptomatic medications were initiated. It is critical to be aware of risk factors associated with the rapid progression of ADPKD in order to be able to provide a favorable impact on the disease prevention and management.
МЕТОДИКА ВЫПОЛНЕНИЯ МОДИФИЦИРОВАННОЙ ОПЕРАЦИИ КОЛЬПОКЛЕЙЗИС У ПАЦИЕНТОК С ТЯЖЕЛЫМИ ФОРМАМИ ПРОЛАПСА ТАЗОВЫХ ОРГАНОВ
Authors: Плеханов А. Н. , Беженарь Ф. В. , Епифанова Т. А.
Published: February 2024

На данный момент не существует общей универсальной единой тактики хирургического лечения больных с пролапсом тазовых органов. Учитывая риски установки сетчатых имплантатов и участившиеся случаи имплантат-ассоциированных осложнений, вновь актуальными стали методики бессетчатой хирургии тазового дна. Нами был разработан и внедрен в клиническую практику метод, представляющий собой влагалищную гистерэктомию с последующим ушиванием влагалища по типу модифицированной операции кольпоклейзис, что позволяет совместить все преимущества данного метода и одновременно минимизировать риски онкологического профиля в дальнейшем.
МЕТОДИКА ВЛАГАЛИЩНОЙ ГИСТЕРЭКТОМИИ С ИСПОЛЬЗОВАНИЕМ ТРАДИЦИОННОГО И ЭЛЕКТРОХИРУРГИЧЕСКОГО МЕТОДОВ ГЕМОСТАЗА
Authors: Плеханов А. Н. , Епифанова Т. А. , Беженарь Ф. В.
Published: February 2024

Целью данного исследования явилось описание выполнения влагалищной гистерэктомии с использованием двух хирургических методов гемостаза (традиционного лигирования и электрохирургического).
ПАТОФИЗИОЛОГИЯ ХИМИОИНДУЦИРОВАННОЙ ПЕРИФЕРИЧЕСКОЙ НЕЙРОПАТИИ КАК ПРИЧИНА НЕУДАЧ В ПРОФИЛАКТИКЕ ДАННОГО ОСЛОЖНЕНИЯ
Authors: Чиж Г. А. , Рыков И. В. , Орлова Д. С. , Кузин С. О. , Эльмурзаев А. Б. , Шишкин А. Б. , Богомолов В. В.
Published: February 2024

Около 60 % онкологических пациентов, получающих химиотерапевтическое лечение с применением препаратов платины, таксанов, винкаалкалоидов, сталкиваются с химиоиндуцированной периферической нейропатией (ХИПН). Эффективных методов медикаментозной профилактики ХИПН на сегодняшний день нет. В данном обзоре обсуждаются ключевые аспекты патофизиологии ХИПН, которые раскрываются как ключевое препятствие к внедрению эффективных методов медикаментозной профилактики данного осложнения химиотерапевтического лечения.
Historical Evolution of Ideas and Theories Related to the Concept of Civil Society
Authors: Abdul Mueed Kamran  , Syed Shahid Hussain Bukhari
Published: February 2024

The article presents the historical origin and growth of civil society. The philosophies of many philosophers show the ever-changing dimensions of civil society from time to time. The historical debate starts from classical political economists’ views, continues with Hegelian, Marx’s and Gramsci’s notions of civil society and ends at the current debate on civil society. Classical scholars considered civil society as an economic sphere and the property of emerging industrial societies that were characterized by complex segmentation of labor, the centrality of production and economic interactions. They give more importance to the state rather than individuals. Hegel, Karl Marx and Gramsci are the main philosophers of the classical school of thought. Other scholars like Herbert Marcuse, Jurgen Habermas, John Rawls, Michal Sandel, Charles Tayler and Michal Walzer also contributed in the debate of relationship between the state and civil society. Current scholars like Foucault, Derrida, Deliuze, Lyotard, Fradric Jameson and Francis Fukuyama have discussed the term of civil society with new directions and ideas. The main focus of these scholars is state, human rights, morality, socialism, liberalism and social movements. Their main point is that individuals are more important than the state. The major analysis of this article is based on qualitative approach. The article concludes that the nature of ideas about relationship between the state and civil society and the influence of civil society on state and that of state on civil society have shaped civil society in different dimensions in different periods of history.
The Study of Speech Acts in Pakistani Universities’ Vice Chancellors’ Messages: A Pragmatic Lens
Authors: Mamona Yasmin Khan  , Fatima Chaudhary
Published: February 2024

This research aims to explore the manners Pakistani educational leaders/Vice Chancellors perform actions through language in their messages in the educational context. Furthermore, VCs of universities promote education and motivate students to get education reflecting their aims and strategies to infuse positivity and love for knowledge along with responsibility for the country’s progress in their blood. Moreover, this is significant for decoding their messages in an educational context because this inspires the learners. This is a mixed-method inquiry, primary data in the form of VC messages is selected from the official websites of Pakistani universities and analyzed under The Speech Act Theory (Searle, 1969). The findings reveal three types of speech acts in their messages. The percentages of these speech acts are representative (40%), commissive (36%) and Expressive (24%). These speech acts interact with the context and give the intended meaning. Thus, Pakistani Universities’ vice-chancellors in their messages perform representative commissive and expressive speech acts to promote education and to motivate students for the future another function is the role of these speech acts in the promotion of universities to increase the admission ratio.
Historical Insights of Global Power Transitions: Implications on US-China Relations
Authors: Asad Ali  , Amir Ahmed Khuhro
Published: February 2024

The history of global power transitions is a complex and multifaceted topic that has far-reaching implications on various aspects of international relations, including US-China relations. Throughout history, there have been numerous instances where the balance of power between nations has shifted, leading to significant changes in the global order. This research is aimed to analyse the prospects and implications of the current global power transition. Since the relative decline of the United States and the rise of China, the US-China relationship is one of the recurring themes in international relations. The pace of rise of the rest, especially China, is shrinking the power gap between the United States and these competitors. This paper suggests that the United States has gone through a relative decline in its military, economic, and soft power capabilities. The current trade war between the two largest economies, COVID-19 and other factors have exacerbated souring US-China relations. The realist theorists suggest that the ‘rising states are always prone to provoke war’, however, as China continues to increase its economic and military capabilities, the US has become increasingly wary of its rise and has adopted a more confrontational approach towards the country. This has led to a series of trade disputes, military tensions, and geopolitical conflicts between the two nations. The rise of China today is possible because of benefitting from the contemporary global order, but at the same time, China is dissatisfied with the role of the United States or a group of certain states in manipulating the laws of international institutions to pursue their self-interest. To avoid hostility, the largest economies should emphasize global issues by endorsing economic interdependence and cooperation.
An Exploratory Overview of Teacher Educators’ Demographic Based Insight Regarding Standards of Quality of Teacher Education in Public Sector Universities of Pakistan
Authors: Muhammad Shahzad Naseem  , Farah Deeba
Published: February 2024

The quality of teacher education is highly contingent on professional standards and teachers’ firm belief in these standards. By following the standards, teacher education can be revolutionized. Keeping in view this utmost need of standards, the present study was envisioned to review teacher educator’s insight regarding standards of quality of teacher education. For this purpose, an exploratory survey was conducted with the help of an open ended questionnaire based on ten national professional standards. Two demographics gender and teachers’ designation were focused. Questionnaire was administered over 55 teacher educators out of which 49 questionnaire were returned. These teacher educators were purposively selected as they were teaching to preservice teachers in teacher education departments of various public sector universities of Punjab, KP and Federal. There were total 15 questions in this questionnaire. Results of the study concluded that majority of teachers were well aware of these standards. In all standards data showed a marginal gender based difference. However,in terms of training teachers revealed that there is lack of training regarding implementation of these standards. Teachers were found weak in standard of professional code of conduct and assessment techniques. Half of the majority of teachers were hopeful that standards can improve quality of teacher education. The study recommends training program for teachers for teachers’ continuous professional development and to empower them for using ICTs and for opting diverse assessment techniques.
Impact of Firm's Value Relevance of Accounting Information on Stock Returns during Market over and under Reactions in Pakistan
Authors: Dil Nawaz  , Abdul Rasheed  , Waleed Khalid
Published: February 2024

Value relevance of accounting information (VRAI) is a fundamental characteristic of influencing stock returns. This study analyzes the impact of VRAI on stock returns during market under and overreaction in Pakistan. The data of 322 non-financial firms listed in PSX from 2005 to 2022 is used. To explain stock returns, we employ the annual stock returns and buying and holding returns model. The data on financial variables has been collected from annual reports published on the company's websites and PSX Data Stream. The outcomes show that the accounting information variables earnings per share and change in earnings per share are positively related to the stock returns during market over and under reaction. Earnings per share, net income and book value are significantly related to the BHAR diuuring market under and overreaction while earnings per share and book value are significantly related to the BHAR during market overreaction of non-financial firms. It is also concluded that balance sheet variables attract more investors to invest in the stock market during the underreaction of non-financial firms. Therefore, it is suggested that the non-financial firms must present adequate accounting information on their financial statements within the specified time frame.
Integrating Virtual Reality Laboratories (VRLs) in Chemistry Education: A Systematic Literature Review
Authors: Guruloo Thelugu Novah Mary , Osman Kamisah
Published: February 2024

This systematic literature review investigates the importance of integrating Virtual Reality (VR) in chemistry education. It was discovered that only six countries are actively implementing and improving Virtual Reality Laboratories (VRLs) in chemistry education, with the United States (US) being the foremost country in research on VRLs. After 2021, there has been a significant surge in interest in the field, particularly through the Oculus system. Two specific topics that can be augmented by VR learning are laboratory safety and studying atomic and molecular structures. Unity 3D is the most widely used and accessible programming tool, and further studies are necessary to broaden the precise application of VR in chemistry education within the ASEAN and Malaysian settings.
Rezension von: Baaken, Katrin; Baaken, Gerhard (Bearb.), Namenregister, Ergänzungen und Berichtigungen, Nachträge
Authors: Ulshöfer Kuno , Baaken Katrin , Baaken Gerhard
Published: February 2024

J. F. Böhmer: Regesta Imperii. Hg. von der Kommission für die Neubearbeitung der Regesta Imperii bei der Österreichischen Akademie der Wissenschaften und der Deutschen Kommission für die Bearbeitung der Regesta Imperii. IV. Ältere Staufer, dritte Abt.: Die Regesten des Kaiserreiches unter Heinrich IV. 1165 (1190)—1197. Namenregister, Ergänzungen und Berichtigungen, Nachträge. Bearb. von Karin und Gerhard Baaken. Köln-Wien: Böhlau 1979. 202 S.
Rezension von: Ilien, Albert; Jeggle, Utz, Leben auf dem Dorf
Authors: Göpfert Eberhard , Ilien Albert , Jeggle Utz
Published: February 2024

Albert Ilien, Utz Jeggle: Leben auf dem Dorf. Zur Sozialgeschichte des Dorfes und zur Sozialpsychologie seiner Bewohner. Opladen: Westdeutscher Verlag 1978. 186 S.
Rezension von: Nuss, Fritz, Medaillen
Authors: Grünenwald Elisabeth , Nuss Fritz
Published: February 2024

Fritz Nuss: Medaillen. Mit Texten von Otto Marzinek und Otto Heuscheie. Stuttgart-Aalen: Theiss 1977. 24 S. Text in Deutsch, Französisch, Englisch und Italienisch, 114 Abb.
Deep Learning-Based Medical Image Registration Algorithm: Enhancing Accuracy with Dense Connections and Channel Attention Mechanisms
Authors: Gong Yulu , Liu Houze , Li Lianwei , Tian Jingxiao , Li Hanzhe
Published: February 2024

In critical clinical medical image analysis applications, such as surgical navigation and tumor monitoring, image registration is crucial. Recognizing the potential for enhanced accuracy in existing unsupervised image registration techniques for single-modal imagery, this research introduces an innovative deep learning-based image registration algorithm. Its novelty resides in integrating short and long connections to create a densely connected structure, markedly refining the feature map interconnectivity within the U-Net architecture. This advancement addresses the significant semantic gap issues arising from disparities in feature map sampling depths. Moreover, the algorithm incorporates a channel attention mechanism within the U-shaped network's decoder, significantly mitigating image noise and facilitating the generation of smoother deformation fields. This enhancement not only boosts the model's detail sensitivity but also markedly increases image registration precision, particularly evident when processing single-modal brain MRI datasets, thereby proving the algorithm's efficacy and utility. Extensive clinical application-based training and testing have underscored this algorithm's substantial contributions to medical image registration accuracy enhancement. Overall, by leveraging deep learning technologies and innovative algorithmic structures, this study addresses pivotal challenges in medical image registration, offering more precise and dependable support for clinical applications like surgical navigation and tumor surveillance.
Enhancing Credit Card Fraud Detection: A Neural Network and SMOTE Integrated Approach
Authors: Zhu Mengran , Zhang Ye , Gong Yulu , Xu Changxin , Xiang Yafei
Published: February 2024

Credit card fraud detection is a critical challenge in the financial sector, demanding sophisticated approaches to accurately identify fraudulent transactions. This research proposes an innovative methodology combining Neural Networks (NN) and Synthetic Minority Over-sampling Technique (SMOTE) to enhance the detection performance. The study addresses the inherent imbalance in credit card transaction data, focusing on technical advancements for robust and precise fraud detection. Results demonstrate that the integration of NN and SMOTE exhibits superior precision, recall, and F1-score compared to traditional models, highlighting its potential as an advanced solution for handling imbalanced datasets in credit card fraud detection scenarios. This research contributes to the ongoing efforts to develop effective and efficient mechanisms for safeguarding financial transactions from fraudulent activities.
Enhancing Security in DevOps by Integrating Artificial Intelligence and Machine Learning
Authors: Liang Penghao , Wu Yichao , Xu Zheng , Xiao Shilong , Yuan Jiaqiang
Published: February 2024

In modern software development and operations, DevOps (a combination of development and operations) has become a key methodology aimed at accelerating delivery, improving quality and enhancing security. Meanwhile, artificial intelligence (AI) and machine learning (ML) are also playing an increasingly important role in cybersecurity, helping to identify and respond to increasingly complex threats. In this article, we'll explore how AI and ML can be integrated into DevOps practices to ensure the security of software development and operations processes. We'll cover best practices, including how to use AI and ML for security-critical tasks such as threat detection, vulnerability management, and authentication. In addition, we will provide several case studies that show how these technologies have been successfully applied in real projects and how they have improved security, reduced risk and accelerated delivery. Finally, through this article, readers will learn how to fully leverage AI and ML in the DevOps process to improve software security, reduce potential risks, and provide more reliable solutions for modern software development and operations.
Utilizing AI-Enhanced Multi-Omics Integration for Predictive Modeling of Disease Susceptibility in Functional Phenotypes
Authors: Zhou Yanlin , She Xinyu , He Zheng , Weng Huiying , Chen Wangmei
Published: February 2024

With the continuous development of machine learning technology, the scientific research of biomedical materials is gradually shifting to a data-driven direction. The rise of this trend stems from the widespread use of Bio sequencing technology, which provides entirely new methods and insights for testing and evaluating the biological function of biomedical materials. The performance and performance of biomedical materials have a wide range of applications in medical applications, drug delivery, biosensors and other fields, so it is important to further optimize them. However, with the accumulation and increasing complexity of data, there is a need for more intelligent and efficient ways to process and analyze this heterogeneous scientific data. Therefore, the establishment of an open, shared infrastructure for storing heterogeneous scientific data from different research fields will be the cornerstone of cross-disciplinary joint analysis. This infrastructure will not only accelerate the collection and integration of data, but will also provide opportunities for collaboration and innovation across disciplines. This paper highlights a new trend in biomedical materials research, namely a data-driven approach, and the key role of Bio sequencing technology in this process. At the same time, we call for the establishment of an open data storage and sharing platform to promote multidisciplinary cooperation, accelerate the optimization and innovation of biomedical materials, and open up broader prospects for future biomedical applications. This effort is expected to push scientific research in the medical field to new heights, providing safer and more effective treatments and medical programs for patients.
Enhancing E-commerce Chatbots with Falcon-7B and 16-bit Full Quantization
Authors: Luo Yang , Wei Zibu , Xu Guokun , Li Zhengning , Xie Ying , Yin Yibo
Published: February 2024

E-commerce chatbots play a crucial role in customer service but often struggle with understanding complex queries. This study introduces a breakthrough approach leveraging the Falcon-7B model, a state-of-the-art Large Language Model (LLM) with 7 billion parameters. Trained on a vast dataset of 1,500 billion tokens from RefinedWeb and curated corpora, the Falcon-7B model excels in natural language understanding and generation. Notably, its 16-bit full quantization transformer ensures efficient computation without compromising scalability or performance. By harnessing cutting-edge machine learning techniques, our method aims to redefine e-commerce chatbot systems, providing businesses with a robust solution for delivering personalized customer experiences.
The inflationary spike in Spain between 2021 and 2023: evidence from micro data
Authors: Gutiérrez Chacón Eduardo , Roldan Blanco Pau
Published: February 2024

Rationale

Analysis of the price micro data used to construct the consumer price index (CPI) allows us to understand how much of the inflationary spike observed in Spain between 2021 and 2023 was attributable to changes in the number of outlets adjusting prices (the “adjustment frequency”), rather than to changes in the size of such price adjustments.

Takeaways

•The rise in the year-on-year growth rate of the CPI in 2021-2023 was marked by notable increases in the number of outlets that raised their prices from one month to the next, with the size of such price adjustments remaining practically constant.

•There is evidence of asymmetries in the upward and downward price adjustments made by outlets: given the same gap between a posted price and the estimated optimal price, the number of outlets making an upward price adjustment towards the optimal price exceeds those outlets making equivalent downward adjustments. This asymmetry has become more marked during the recent inflationary period.
Building trust to prevent banking crises
Authors: Laboureix Dominique , Pozlep Mark
Published: February 2024

Banking crises are a feature of the modern financial system. However, their impact and
probability can be mitigated by building trust in the banking sector. This is primarily achieved
by banks themselves. However, with vigilant ex-ante monitoring and swift and decisive action
when a banking crisis emerges, regulators can shore up trust in the banking sector. The Single
Resolution Board, as the banking union’s central resolution authority, is a key element of the
post-global financial crisis regulatory framework and has been promoting trust in the banking
sector by making banks more resolvable.
MODEL PEMBERDAYAAN MASYARAKAT DI “KAMPUNG BEBEK DAN TELUR ASIN” DESA KEBONSARI KECAMATAN CANDI KABUPATEN SIDOARJO (Studi Pada Kelompok Peternak Itik Sumber Pangan)
Authors: Arif Syaifudin
Published: February 2024

Berdasarkan Fenomena Yang Terjadi Pada Pengusaha Bebek Dan Telur Asin Adalah Pemberdayaan Pengusaha Bebek Dan Telur Asin Untuk Meningkatkan Daya Saing, Kemandirian Usaha Dan Organisasinya Yang Pada Akhirnya Akan Berdampak Pada Kesejahteraan Pengusaha. Tujuan Penelitian Ini Dilakukan Untuk Meningkatkan Kemandirian Dan Mengorganisasi Masyarakat. Kelompok Peternak Itik “Sumber Pangan”. Metode Dalam Penelitian Ini Adalah Metode Kualitatif Deskriptif Dengan Cara Interview Langsung Degan Informan. Hasil Penelitian Dapat Disimpulkan Bahwa Kepercayaan Para Peternak Bebek Terhadap Kelompok Peternak Sudah Mulai Terbangun Kembali, Sehingga Peternak Bebek Kembali Mempercayakan Hasil Ternaknya Kepada Kelompok Bukan Kepada Tengkulak. Kemudian Pemerintah Kabupaten Sidoarjo, Pemberdayaan Yang Dilakukan Di Kampung Bebek Dan Telur Asin Bersifat Continue. Aspek Hulu Hilir Terkait Peningkatan Kapasitas Dan Proses Pemberdayaan Peternak Bebek Akan Bermuara Pada Peningkatan Daya Saing Dan Siap Sebagai Masyarakat Yang Mandiri.
Influências da pandemia de COVID-19 sobre os agricultores familiares da feira municipal de Colorado do Oeste - RO
Authors: Werlang Kairon Lucas , Lima Valdique Gilberto , Ferreira de Paula Nelio Ranieli , Pires de Paula Frank William
Published: February 2024

O presente artigo tem como objetivo investigar os efeitos causados pela pandemia de COVID-19 aos agricultores familiares da feira municipal de Colorado do Oeste - RO. É uma pesquisa de abordagem qualitativa, no qual foi utilizado um questionário para obter dados durante entrevistas, realizada com onze feirantes que praticam a mão de obra familiar como sua principal atividade de obtenção de renda. O resultado da investigação multidimensional realizado no segundo semestre de 2021 foi alcançado e apresentados às influências causadas pela pandemia na comercialização dos produtos na feira municipal, estes que são oriundos da agricultura familiar.
EXAMINING THE ROLE OF BUSINESS ANALYTICS CAPABILITY IN FIRMS' AGILITY & PERFORMANCE: EVIDENCE FROM MANUFACTURING SECTOR
Authors: Zafar Saad , Ali Taha Yab , Uddin Abbas
Published: February 2024

The purpose of study is to analyze empirically effect of Business Analytics Capability (BAC) on agility and performance of firms by focusing on role of Information Quality (IQ) and Innovative Capability (IC). The research was conducted using a quantitative research design focusing on workers in manufacturing sector in Pakistan. The data attained from a sample of 350 managerial-level workers in Lahore by means of structured questionnaire survey supports the significant positive relationship between BAC & both FA and FPP. The study reveals the strong and positive relationship between IQ & firms’ adaptability, productivity and significant and positive impact of innovative capability on organizations’ agility and efficiency. The study emphasizes complexity of factors critical for organizational success within organizational context. The significance of results extends beyond reach of study, providing relevant insights into academic and professional contexts. The existing theoretical frameworks can be strengthened by adding these aforementioned antecedents and managers should exploit this opportunity in order to improve organizational agility and performance in the dynamic manufacturing environment.
Estado del arte sobre modelos de circulación global para resistir el problema del cambio climático
Authors: Gaitán Muñoz Verónica Elizabeth
Published: February 2024

Este artículo presenta un Estado del Arte sobre Modelos de Circulación Global para resistir el problema del Cambio Climático. La relevancia de este estudio consiste en la compresión sobre el downscaling que es un proceso que implica la transformación de datos a una resolución espacial más fina. En este trabajo se verá la clasificación de los modelos climáticos en dos grandes tipos, modelos de circulación global (MCG, o GCM, por sus siglas en inglés) que cubren todo el Planeta y Modelos Climáticos Regionales (MCR, o RCM, por sus siglas en inglés) que abarcan una Región climática limitada. La información proporcionada por los GCM, suelen tener una resolución de entre 100 y 200 km de cuadrícula, la cual es adecuada para el soporte en la toma de decisiones a escala internacional. El estudio es de alcance exploratorio y emplea una metodología de estado del arte, la cual es de tipo documental y de carácter crítico interpretativo, se trabajó con ocho trabajos representativos. Los resultados del estudio apuntan a que en su mayoría, en que no se han estudiado a cabalidad, una técnica de reducción de escala de 2° a 0.5° (Statistical Downscaling Model, SDSM) para obtener información detallada de cambios en parámetros asociados a calidad en la construcción de proyecciones locales de temperatura y precipitación.
Turismo sostenible desde la responsabilidad social de las empresas turísticas
Authors: Sevilla Ubeda María Argentina , Hurtado Cerna Yarineth Alexey , Hurtado Miurett Jasnary , Villanueva Jenny del Socorro , Mendoza Castro Concepción
Published: February 2024

El presente trabajo investigativo tiene como objetivo determinar el turismo sostenible desde la responsabilidad social de las empresas turísticas, mediante estudios realizados por países latinoamericanos como Perú, Colombia y Nicaragua, para determinar de qué manera las empresas han sido responsables en relación con cada uno de los ejes de sostenibilidad. Esta investigación se realizó siguiendo los lineamientos de cada uno de los objetivos planteados, iniciando por definir los aspectos teóricos del turismo sostenible y la responsabilidad social de las empresas turísticas, seguido de esto describiendo la responsabilidad social en relación con los ejes de la sostenibilidad como el eje ambiental, socio-cultural y económico, y finalmente demostrando como las empresas turísticas han sido responsables en relación con los ejes de la sostenibilidad durante un período de tiempo determinado. La metodología es de carácter documental, ya que es un método de recogida de datos en un contexto de estudios principalmente científicos, que se llevó a cabo utilizando herramientas hermenéuticas (fichajes y focalización) como instrumento de análisis e interpretación. Entre los principales resultados se obtuvo que las empresas tomadas en cuenta, han sido  responsables con los ejes de la sostenibilidad, algunas con más inclinación en lo ambiental en relación a la conservación del medioambiente, y otras en lo sociocultural, desde las colaboraciones en proyectos sociales hasta el respeto y bienestar de los trabajadores, otras con el eje económico vinculado con las aportaciones y las relaciones que se crean con los clientes, así logrando sostenibilidad en sus servicios y productos ofertados a los turistas
Desarrollo de la robótica educativa en Nicaragua: Enfoque en la educación media y el uso de kits de robótica
Authors: Herradora Romero Eddys Alberto
Published: February 2024

La integración de la robótica en la educación media ha sido una tendencia creciente en los últimos años. Los kits de robótica se han convertido en una herramienta valiosa para enseñar conceptos de física y matemáticas de una manera más práctica y visualmente atractiva para los estudiantes. Los kits de robótica permiten a los estudiantes construir y programar robots para realizar tareas específicas. Esto les da la oportunidad de aplicar los conceptos teóricos que han aprendido en clase en un contexto práctico y tangible. Además, los estudiantes pueden experimentar con diferentes diseños y programas para ver cómo afectan el comportamiento del robot. La integración de la robótica en la educación media también puede ayudar a los estudiantes a desarrollar habilidades importantes, como la resolución de problemas, la creatividad y la colaboración. Trabajar en equipo para construir y programar un robot puede ser una experiencia enriquecedora y motivadora para los estudiantes. En el área de física, los kits de robótica pueden utilizarse para enseñar conceptos como la cinemática, la dinámica y la energía. Los estudiantes pueden construir robots que simulen el movimiento de objetos en diferentes situaciones y ver cómo cambia el comportamiento del robot en función de los parámetros que han programado. En el área de matemáticas, los kits de robótica pueden utilizarse para enseñar conceptos como la geometría, la trigonometría y la programación lineal. Los estudiantes pueden construir robots que realicen cálculos matemáticos complejos y ver cómo se aplican estos conceptos en un contexto práctico. En resumen, la integración de la robótica en la educación media puede ser una herramienta valiosa para enseñar conceptos de física y matemáticas de una manera más práctica y visualmente atractiva para los estudiantes. Además, puede ayudar a desarrollar habilidades importantes como la resolución de problemas, la creatividad y la colaboración.
Ảnh hưởng của độ mặn và chế độ cho ăn lên tốc độ tăng trưởng và tỉ lệ sống của tôm he ấn độ Penaeus indicus
Authors: Hoàng Tùng  , Trương Ái Nguyên  , Hồ Hải Cơ  , Võ Thị Minh Thư
Published: February 2024

Nghiên cứu này kiểm chứng giả thuyết về tác dụng tích cực của việc cho tôm ăn 30% khẩu phần ăn vào ban đêm và ảnh hưởng của độ mặn lên tỉ lệ sống, tốc độ tăng trưởng và hệ số chuyển đổi thức ăn FCR của tôm he Ấn Độ Penaeus indicus. Thí nghiệm được thiết kế theo kiểu Split-plot với yếu tố chính là độ mặn (15 hoặc 30 ppt) và yếu tố phụ là chế độ cho ăn (ban ngày hoặc cả ngày lẫn đêm). Kết quả cho thấy độ mặn ảnh hưởng đến tất cả các thông số quan sát. Tôm được nuôi ở độ mặn 30 ppt có tỉ lệ sống, FCR và tốc độ tang trưởng cao hơn so với độ mặn 15 ppt (P < 0,05). Trong khi đó, cho tôm ăn 30% khẩu phần vào ban đêm cải thiện tốc độ tăng trưởng (P < 0,05) nhưng không ảnh hưởng đến tỉ lệ sống và FCR của tôm thí nghiệm (P > 0,05). Kiểm định thống kê không ghi nhận tương tác giữa 2 yếu tố nghiên cứu là độ mặn và chế độ cho ăn (P > 0,05). Chúng tôi đề xuất nên nuôi tôm he Ấn Độ ở độ mặn 30 ppt và cho tôm ăn cả ban ngày lẫn đêm để cải thiện tốc độ tăng trưởng, rút ngắn thời gian nuôi và tiết kiệm chi phí thức ăn.

Từ khóa: Penaeus indicus, tăng trưởng, độ mặn, chế độ cho ăn
Quan trắc khả năng di chuyển của tôm càng xanh ở các lưu tốc nước trong điều kiện thí nghiệm thủy lực, với liên hệ thực tế cho đường di cư qua đập Phước Hòa
Authors: Vũ Văn Hiếu  , Vũ Cẩm Lương  , Nguyễn Nghĩa Hùng
Published: February 2024

Tôm càng xanh (Macrobrachium rosenbergii) được đánh giá là loài thủy sản di cư bị ảnh hưởng trực tiếp bởi đập Phước Hòa trên sông Bé. Nghiên cứu này là tiền đề để đề xuất chế độ vận hành lưu tốc nước phù hợp cho tôm càng xanh (TCX) di cư ở đường di cư qua đập (ĐDCQĐ) Phước Hòa. Nội dung nghiên cứu bao gồm: (1) Khảo sát hiện trạng vận hành lưu tốc nước và các thông số thiết kế của ĐDCQĐ Phước Hòa; (2) Quan trắc tỷ lệ và tốc độ TCX di chuyển qua kênh nước hở ở các lưu tốc nước; (3) Quan trắc tỷ lệ TCX duy trì phía đầu kênh ở các lưu tốc nước trong các khoảng thời gian kéo dài. Nghiên cứu được thực hiện trên hai cỡ TCX là 7,5-9,5 cm (TCX cỡ I) và 13,5-15,5 cm (TCX cỡ II), với kênh tạo lưu tốc nước dài 18 m trong điều kiện phòng thí nghiệm thủy lực. Kết quả khảo sát hiện trạng vận hành lưu tốc nước của ĐDCQĐ Phước Hòa ghi nhận mức lưu tốc nước trung bình vào mùa khô, mùa mưa và lưu tốc nước tối đa vào mùa mưa của ĐDCQĐ Phước Hòa lần lượt là 0,26, 0,59 và 0,90 m/s, làm cơ sở cho ba mức bố trí lưu tốc nước (0,3, 0,6 và 0,9 m/s) trong điều kiện thí nghiệm. Kết quả quan trắc tỷ lệ TCX di chuyển qua kênh dài 18 m trong 10, 20 và 30 phút ở lưu tốc nước 0,3 m/s lần lượt là 13,33, 68,33, 94,17% cho TCX cỡ I; và 21,66, 76,00, 98,33% cho TCX cỡ II; ở lưu tốc nước 0,6 m/s lần lượt là 2,50, 50,83, 79,16% cho TCX cỡ I; và 9,16, 61,66, 90,83% cho TCX cỡ II; ở lưu tốc nước 0,9 m/s, tỷ lệ TCX di chuyển qua kênh dài 18 m là 0%. Tốc độ TCX di chuyển qua kênh dài 18 m ở lưu tốc nước 0,3 và 0,6 m/s lần lượt là 1,15 và 0,92 m/phút cho TCX cỡ I; 1,18 và 0,96 m/phút cho TCX cỡ II, cho thấy TCX cỡ I và II cần tối thiểu lần lượt là 11,81 và 11,51 giờ ở lưu tốc nước 0,3 m/s; 14,76 và 14,15 giờ ở lưu tốc nước 0,6 m/s để di chuyển giữa các hồ nghỉ xa nhất trên ĐDCQĐ Phước Hòa. Tỷ lệ TCX duy trì trên kênh trong 5, 10 và 15 giờ ở lưu tốc nước 0,3 m/s lần lượt là 88,33, 69,17, 30,83% cho TCX cỡ I; và 91,67, 83,33, 47,50% cho TCX cỡ II; ở lưu tốc nước 0,6 m/s lần lượt là 70,83, 36,67, 0% cho TCX cỡ I; và 82,50, 48,33, 12,50% cho TCX cỡ II. Kết quả của nghiên cứu được liên hệ thực tế cho ĐDCQĐ Phước Hòa với đề xuất chế độ vận hànhlưu tốc nước xung quanh 0,6 m/s và bổ sung thêm hồ nghỉ dọc ĐDCQĐ để tăng hiệu quả di chuyển của TCX qua ĐDCQĐ Phước Hòa.

Từ khóa: Khả năng di chuyển, lưu tốc nước, tôm càng xanh, đường di cư qua đập, Phước Hòa.
Hiệu quả phòng trừ sinh học bệnh hoại tử gan tụy cấp tính (AHPND) gây ra bởi Vibrio parahaemolyticus NT2.5 trên tôm thẻ từ in vitro tới quy mô nuôi thương phẩm của chế phẩm vi sinh CPVS 01 và CPVS 02
Authors: Nguyễn Văn Minh  , Nguyễn Văn Có  , Trần Kiến Đức  , Nguyễn Sen  , Nguyễn Văn Dũng  , Dư Ngọc Tuân
Published: February 2024

Trong nghiên cứu này, bằng phương pháp khuếch tán giếng thạch, chúng tôi sàng lọc được chủng Bacillus polyfermenticus F27 đối kháng Vibrio parahaemolyticus NT2.5, với đường kính lớn nhất là 18,50 mm. B. polyfermenticus F27 được chứng minh có khả năng kiểm soát sinh học V. parahaemolyticus NT2.5 khi thử nghiệm nuôi tôm trong thùng 25 lít, mật độ 106 và 107 CFU/ mL giúp tôm đạt tỷ lệ sống lần lượt là 75,55 ± 3,85 % và 82,22 ± 3,85 % và có tỷ lệ bảo vệ RPS (%) lần lượt là 73,17 % và 80,49 %. Chế phẩm sinh học CPVS 01 dùng để trộn thức ăn nhằm ức chế vi khuẩn V. parahaemolyticus trong đường ruột tôm, CPVS 02 dùng xử lý nước nuôi tôm nhằm ức chế vi khuẩn V. parahaemolyticus trong ao nuôi tôm đã được nghiên cứu sản xuất. Ở thí nghiệm trong quy mô bể 1,5 m³, kết quả kiểm soát sinh học V. parahaemolyticus NT2.5 gây bệnh AHPND của chủng 2 loại chế phẩm vi sinh ở mật độ 106 và 107 CFU/ mL đạt tỷ lệ sống lần lượt là 78,17 ± 3,79 %, 84,33 ± 2,75 % và tỷ lệ bảo vệ RPS (%) lần lượt là 77,61 %, 83,93 %. Thử nghiệm trên ao nuôi tôm thương phẩm, ao 9C dương tính bệnh AHPND từ ngày thứ 50 nhưng tôm vẫn ăn, phát triển bình thường, không có biểu hiện chết hàng loạt của bệnh AHPND. Kết quả nghiên cứu cho thấy chế phẩm CPVS 01 và CPVS 02 có tiềm năng ứng dụng để phòng trừ sinh học bệnh AHPND trên tôm thẻ nuôi thương phẩm.

Từ khóa: bệnh hoại tử gan tụy cấp tính, tôm thẻ chân trắng, Vibrio parahaemolyticus NT2.5, chế phẩm sinh học, Bacillus polyfermenticus F27
Should We Consider UGT1A1 Mutation Analysis in Evaluating the Prolonged Jaundice of Newborn Infants?
Authors: Kim Young Don
Published: February 2024

Purpose: Uridine diphosphate glucuronosyltransferase 1A isoform 1 (UGT1A1) is a crucial enzyme in bilirubin metabolism. Mutations in this gene cause prolonged unconjugated hyperbilirubinemia in infants. This study aimed to investigate the prevalence of UGT1A1 mutations and their association with prolonged, unexplained, and unconjugated hyperbilirubinemia in infants.Methods: From July 2019 to March 2023, 74 infants with prolonged jaundice lasting >21 days were enrolled in this study. Diagnostic evaluations, including UGT1A1 mutation analysis, were performed to identify the underlying causes of hyperbilirubinemia. This retrospective review evaluated the incidence and types of mutations in UGT1A1. The clinical and laboratory findings were compared based on the specific mutations detected.Results: Thirty-three infants agreed to UGT1A1 mutation analysis, and 30 (90.9%) were positive for UGT1A1 mutations. Single-nucleotide variants were detected in 20 (66. %) infants. The remaining 10 (33.3%) infants had multiple variants. No significant demographic differences were observed between the group that underwent UGT1A1 mutation analysis and the group that did not. Among the identified genetic variants, c.211G>A (46.5%) and c.-3275T>G (30.2%) were the two most common variants. The other variants had the following percentages: c.1456T>G, c.-64G>C, and c.1091C>T (4.7% each); and c.-3152G>A, c.189C>T, and c.-41.-40 dup (2.3% each). Among the 20 infants with the c.211G>A variant, eight (40.0%) had a homozygous genotype and 12 (60.0%) had a heterozygous genotype. Infants harboring other variants exhibited heterozygous genotypes. When comparing the group with confirmed UGT1A1 mutations to the group without detected mutations, breastfeeding was the only significant factor (p=0.027). No significant differences were found between the group with singlenucleotide variants and the group with multiple genetic variants or between the homozygous genotype group with c.211G>A and the heterozygous genotype group.Conclusion: Neonates with prolonged unconjugated hyperbilirubinemia may have a higher chance of UGT1A1 mutation than expected. Analysis of UGT1A1 mutations may be beneficial in infants with prolonged unexplained jaundice.
The Revolution in Germline DNA Testing: Actionable Takeaways from the 2023 Precision Oncology Summit
Authors: Abuali Inas , Abrams Hannah , Khan Abdul Moiz , Riano Ivy , Munster Pamela , Yadav Siddhartha , Dubard-Gault Marianne
Published: February 2024

The 2023 Precision Oncology Summit was held in San Francisco on October 7th and 8th, focusing on actionable strategies addressing personalized treatment to improve patient outcomes. This manuscript summarizes the discussion and key learning points from “The Revolution in Germline DNA Testing” session.
Gastrointestinal Malignancies: Actionable Takeaways from the 2023 Precision Oncology Summit
Authors: Abuali Inas , Riano Ivy , Abrams Hannah , Khan Abdul Moiz , Ji Hanlee P
Published: February 2024

The 2023 Precision Oncology Summit was held in San Francisco on October 7th and 8th, focusing on actionable strategies addressing personalized treatment to improve patient outcomes. This manuscript summarizes the discussion and key learning points from the precision medicine clinical science symposium in gastrointestinal (GI) malignancies.
Suppression of Leaf Spot Disease in Peanut (Arachis hypogaea) with Chlorothalonil, Copper Salts of Fatty Acid Rosins, and Microionized Sulfur
Authors: Jordan David
Published: February 2024

Concern over evolved resistance to fungicides that are quinone outside inhibitors (QOI), demethylation inhibitors (DMI), and succinate dehydrogenase inhibitors (SDHI) and possible restrictions on the use of the multi-site fungicide chlorothalonil for resistance management have increased the need to develop alternatives to current fungicide programs designed to protect peanut (Arachis hypogaea L.) from late leaf spot disease [caused by Nothopassalora personata (Berk. & M.A. Curtis) U. Braun, C. Nakash., Videira & Crous]. Research was conducted in North Carolina to determine the effectiveness of copper salts of fatty acid rosins and microionized sulfur in protecting peanut yield from canopy defoliation caused by late leaf spot disease. In one experiment, chlorothalonil was more effective in protecting peanut from leaf spot disease than copper salts of fatty acid rosins when these fungicides were applied five times on 14-day intervals during the cropping cycle when the pathogen was active. Chlorothalonil decreased defoliation caused by late leaf spot disease when co-applied with a diverse fungicide program consisting of prothioconazole plus tebuconazole, azoxystrobin, and pyraclostrobin compared with these fungicides without chlorothalonil. Copper salts of fatty acid rosins did not affect defoliation with the diverse fungicide program. In a second experiment, defoliation was similar when azoxystrobin or prothioconazole plus tebuconazole were applied alone or with microionized sulfur. Microionized sulfur provided similar protection from canopy defoliation compared with the more diverse fungicide programs.
The Application Status and Prospects of Solar Photovoltaic Power Generation Technology in China
Authors: Zhao Kunqi , Liu Li , Xing Cheng
Published: February 2024

Solar photovoltaic power generation, as an environmentally friendly energy technology that converts sunlight into electricity, directly converts sunlight into electricity through the use of solar panels, further producing clean and environmentally friendly electricity. Through the analysis of the development status of China's solar photovoltaic power generation, this article discusses the development direction of China's solar photovoltaic power generation to provide reference for the healthy development of China's solar photovoltaic power generation industry.
FACTORS ASSOCIATED WITH DEVELOPING CHRONIC DAILY HEADACHE IN MIGRAINE PATIENTS
Authors: AYAZ Z , ALI Z
Published: February 2024

To examine the factors associated with developing chronic daily headache in migraine patients. Two hundred patients with migraine were selected for this descriptive study conducted from 01-Sept-2023 to 30-Nov-2023 at the Department of Medicine, Lady Reading Hospital, Medical Teaching Institution, Peshawar. Factors associated with developing chronic daily headache were assessed. SPSS 23 was employed for analyzing the data. The mean age was 38.09±12.03 years. The frequency of chronic daily headache in our study was 31 (15.5%). Female gender (p = 0.02), smoking (p = 0.0001), high caffeine intake (p = 0.0001), painkiller overuse (p = 0.0001) and obesity (p = 0.0001) were factors significantly identified for developing chronic daily headache. We conclude that the factors for developing chronic daily headache in migraine patients were female gender, smoking, high intake of pain relieving medicines, high intake of caffeinated drinks and obesity.
The Effects of -806 T/C and -857 T/C Single Nucleotide Polymorphisms in the TNF-α Gene on Rheumatoid Arthritis Severity and Inflammatory Markers
Authors: Hashim Zainab Majeed , Abdulameer Khalid Abdulhussein
Published: February 2024

Background: Polymorphisms in the TNF-α gene affect the development and progression of rheumatoid arthritis. Objective: To investigate the associations between (-806 T/C) and (-857 T/C) SNPs with rheumatoid arthritis severity and susceptibility in a sample of Iraqi patients. Methods: A case-control study was conducted in Baghdad, Iraq. Twenty healthy controls and 63 patients confirmed to be newly diagnosed with rheumatoid arthritis were included. Those are divided into two groups (patients and controls), and the patients were further subdivided into severe and mild-moderate groups. Samples from those participants were analyzed for clinical and inflammatory parameter measurements. Genotyping by the Sanger method was performed to study the SNPs. Results: No associations were demonstrated between rheumatoid arthritis and polymorphisms at positions -806 and -857. Additionally, there were no differences in the distribution of those SNP genotypes and alleles among the severe and mild-moderate groups. Also, the (-806 C/T) SNP was found to be correlated with DAS 28 in all patients and with hs-CRP in the mild-moderate group. Finally, the -857 C/T SNP was found to be correlated with TNF-α within the mild-moderate group. Conclusions:  Polymorphisms at positions -806 and -857 were not associated with rheumatoid arthritis susceptibility, and the CT genotype of -806 C/T SNP was associated with disease activity.
SISTEM INFORMASI PENGGAJIAN PEGAWAI Di SMK MUHAMADIYAH 3 WATES
Authors: Riyanto Ari Budi
Published: February 2024

Tujuan penelitian ini adalah untuk membangun sebuah sistem informasi yang berhubungan dengan system berbasis komputer, sehingga proses yang dilakukan dapat berlangsung dengan lebih cepat dan efisien serta dapat meminimalkan kesalahan yang mungkin terjadi. Metode penelitian yang dilakukan adalah kualitatif dengan pengumpulan data meliputi studi literatur, wawancara (interview), pengamatan secara langsung (observasi), sedangkan metode pengembangan sistem informasi yang digunakan adalah System Development Life Cycle (SDLC) dengan tahapan; analisa sistem, desain sistem, implementasi sistem, operasi dan pemeliharaan. Dari pengamatasn serta penelitian yang dilakukan dapat diketahui SMK Muhammadiyah 3 Wates memerlukan pengolahan data informasi Penggajian, dan informasi lain yang efektif dan efisien, sehingga diharapkan akan menghasilkan suatu informasi yang lebih baik dengan sistem yang terkomputerisasi.