bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening
Authors: Fernandes Anna Maria A.P. , Messias Marcia C.F. , Duarte Gustavo H.B. , de Santis Gabrielle K.D. , Mecatti Giovana C. , Porcari Andreia M. , Murgu Michael , Simionato Ana Valéria C. , Rocha Thalita , Martinez Carlos A.R. , Carvalho Patricia O.
Published: June 2020

In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10–15 years to appear. Mass spectrometry-based lipidomics is an emerging tool for such clinical diagnosis. We used ultra-performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry operating in high energy collision spectral acquisition mode (MSE) mode (UPLC-QTOF-MSE) and gas chromatography (GC) to investigate differences between the plasmatic lipidic composition of CC patients and control (CTR) subjects. Key enzymes in lipidic metabolism were investigated using immuno-based detection assays. Our partial least squares discriminant analysis (PLS-DA) resulted in a suitable discrimination between CTR and CC plasma samples. Forty-two statistically significant discriminating lipids were putatively identified. Ether lipids showed a prominent presence and accordingly, a decrease in glyceronephosphate O-acyltransferase (GNPAT) enzyme activity was found. A receiver operating characteristic (ROC) curve built for three plasmalogens of phosphatidylserine (PS), named PS(P-36:1), PS(P-38:3) and PS(P-40:5), presented an area under the curve (AUC) of 0.998, and sensitivity and specificity of 100 and 85.7% respectively. These results show significant differences in CC patients’ plasma lipid composition that may be useful in discriminating them from CTR individuals with a special role for plasmalogens.
Wetting Properties of Transparent Anatase/Rutile Mixed Phase Glancing Angle Magnetron Sputtered Nano-TiO2 Films
Authors: Vrakatseli Vasiliki , Farsari Ergina , Mataras Dimitrios
Published: June 2020

Transparent polycrystalline TiO2 thin films have been deposited on unheated glass substrates using RF reactive magnetron sputtering. Depositions were carried out at different glancing angles and with different total gas mixture pressures. The variation of these parameters affected the crystal phase composition and the surface morphology. Depending on the glancing angle and the pressure, rutile, mixed anatase/ rutile and pure anatase were deposited at low substrate temperature. Both hydrophilic and hydrophobic TiO2 were obtained, exhibiting fast photoconversion to superhydrophilic upon UV irradiation. The effect of the materials physicochemical properties on the wettability and rate of the UV induced superhydrophilicity is evaluated.
A mm-Sized Free-Floating Wireless Implantable Opto-Electro Stimulation Device
Authors: Jia Yaoyao , Gong Yan , Weber Arthur , Li Wen , Ghovanloo Maysam
Published: June 2020

Towards a distributed neural interface, consisting of multiple miniaturized implants, for interfacing with large-scale neuronal ensembles over large brain areas, this paper presents a mm-sized free-floating wirelessly-powered implantable opto-electro stimulation (FF-WIOS2) device equipped with 16-ch optical and 4-ch electrical stimulation for reconfigurable neuromodulation. The FF-WIOS2 is wirelessly powered and controlled through a 3-coil inductive link at 60 MHz. The FF-WIOS2 receives stimulation parameters via on-off keying (OOK) while sending its rectified voltage information to an external headstage for closed-loop power control (CLPC) via load-shift-keying (LSK). The FF-WIOS2 system-on-chip (SoC), fabricated in a 0.35-µm standard CMOS process, employs switched-capacitor-based stimulation (SCS) architecture to provide large instantaneous current needed for surpassing the optical stimulation threshold. The SCS charger charges an off-chip capacitor up to 5 V at 37% efficiency. At the onset of stimulation, the capacitor delivers charge with peak current in 1.7–12 mA range to a micro-LED (µLED) array for optical stimulation or 100–700 μA range to a micro-electrode array (MEA) for biphasic electrical stimulation. Active and passive charge balancing circuits are activated in electrical stimulation mode to ensure stimulation safety. In vivo experiments conducted on three anesthetized rats verified the efficacy of the two stimulation mechanisms. The proposed FF-WIOS2 is potentially a reconfigurable tool for performing untethered neuromodulation.
Antimicrobial Susceptibility Pattern of Helicobacter heilmannii and Helicobacter ailurogastricus Isolates
Authors: Matos Rita , De Witte Chloë , Smet Annemieke , Berlamont Helena , De Bruyckere Sofie , Amorim Irina , Gärtner Fátima , Haesebrouck Freddy
Published: June 2020

A combined agar and broth dilution method followed by qPCR was used to determine the antimicrobial susceptibility of feline H. heilmannii and H. ailurogastricus isolates. All H. ailurogastricus isolates showed a monomodal distribution of MICs for all the antimicrobial agents tested. For H. heilmannii, a bimodal distribution was observed for azithromycin, enrofloxacin, spectinomycin, and lincomycin. Single nucleotide polymorphisms (SNPs) were found in 50S ribosomal proteins L2 and L3 of the H. heilmannii isolate not belonging to the WT population for azithromycin, and in 30S ribosomal proteins S1, S7, and S12 of the isolate not belonging to the WT population for spectinomycin. The antimicrobial resistance mechanism to enrofloxacin and lincomycin remains unknown (2 and 1 H. heilmannii isolate(s), resp.). Furthermore, H. heilmannii isolates showed higher MICs for neomycin compared to H. ailurogastricus isolates which may be related to the presence of SNPs in several 30S and 50S ribosomal protein encoding genes and ribosomal RNA methyltransferase genes. This study shows that acquired resistance to azithromycin, spectinomycin, enrofloxacin, and lincomycin occasionally occurs in feline H. heilmannii isolates. As pets may constitute a source of infection for humans, this should be kept in mind when dealing with a human patient infected with H. heilmannii.
Quantitative Prediction of Fractures in Shale Using the Lithology Combination Index
Authors: Zhang Zhengchen , Li Pingping , Yuan Yujie , Liu Kouqi , Hao Jingyu , Zou Huayao
Published: June 2020

Fractures, which are related to tectonic activity and lithology, have a significant impact on the storage and production of oil and gas in shales. To analyze the impact of lithological factors on fracture development in shales, we selected the shale formation from the Da’anzhai member of the lower Jurassic shales in a weak tectonic deformation zone in the Sichuan Basin. We defined a lithology combination index (LCI), that is, an attribute quantity value of some length artificially defined by exploring the lithology combination. LCI contains information on shale content at a certain depth, the number of layers in a fixed length (lithology window), and the shale content in the lithology window. Fracture porosity is the percentage of pore volume to the apparent volume of the rock. In the experiment, fracture porosity was obtained using 50 samples from six wells, by observing rock slices under a microscope. The relationship between LCI and fracture porosity was analyzed based on machine learning, regression analysis, and weighting methods. The results show that LCI is able to represent the impact of multiple lithological factors (i.e., shale content at a certain depth, the number of layers in the lithology window, and the shale content in the lithology window). The LCI within a thickness of 2 m for the lithology window demonstrates a good linear relationship with fracture porosity. We therefore suggest LCI be used for fracture predictions of shale formations from weak tectonic deformation zones. Our proposed LCI and fracture prediction methods also provide implications for sandstone, mudstone, or carbonate formations under similar processes.
Improving Photoelectrochemical Properties of Anodic WO3 Layers by Optimizing Electrosynthesis Conditions
Authors: Zych Marta , Syrek Karolina , Zaraska Leszek , Sulka Grzegorz D.
Published: June 2020

Although anodic tungsten oxide has attracted increasing attention in recent years, there is still a lack of detailed studies on the photoelectrochemical (PEC) properties of such kind of materials grown in different electrolytes under various sets of conditions. In addition, the morphology of photoanode is not a single factor responsible for its PEC performance. Therefore, the attempt was to correlate different anodizing conditions (especially electrolyte composition) with the surface morphology, oxide thickness, semiconducting, and photoelectrochemical properties of anodized oxide layers. As expected, the surface morphology of WO3 depends strongly on anodizing conditions. Annealing of as-synthesized tungsten oxide layers at 500 °C for 2 h leads to obtaining a monoclinic WO3 phase in all cases. From the Mott-Schottky analysis, it has been confirmed that all as prepared anodic oxide samples are n-type semiconductors. Band gap energy values estimated from incident photon−to−current efficiency (IPCE) measurements neither differ significantly for as−synthesized WO3 layers nor depend on anodizing conditions such as electrolyte composition, time and applied potential. Although the estimated band gaps are similar, photoelectrochemical properties are different because of many different reasons, including the layer morphology (homogeneity, porosity, pore size, active surface area), oxide layer thickness, and semiconducting properties of the material, which depend on the electrolyte composition used for anodization.
Tumor Targeting Effect of Triphenylphosphonium Cations and Folic Acid Coated with Zr-89-Labeled Silica Nanoparticles
Authors: Kim Gun Gyun , Lee Jun Young , Choi Pyeong Seok , Kim Sang Wook , Park Jeong Hoon
Published: June 2020

In this study, we investigated the tumor targeting effect in cancer cells using triphenylphosphonium (TPP) cations, which are accumulated by differences in membrane potential, and folic acid (FA), which is selectively bound to overexpressed receptors on various cancer cells. We used Food and Drug Administration (FDA)-approved silica nanoparticles (SNPs) as drug carriers, and SNPs conjugated with TPP and FA (STFs) samples were prepared by introducing different amounts of TPP and FA onto the nanoparticle surfaces. STF-1, 2, 3, 4 and 5 are named according to the combination ratio of TPP and FA on the particle surface. To confirm the tumor targeting effect, 89Zr (t1/2 = 3.3 days) was coordinated directly to the silanol group of SNP surfaces without chelators. It was shown that the radiochemical yield was 69% and radiochemical purity was >99%. In the cellular uptake evaluation, SNPs with the most TPP (SFT-5) and FA (SFT-1) attached indicated similar uptake tendencies for mouse colon cancer cells (CT-26). However, the results of the cell internalization assay and measurement of positron emission tomography (PET) images showed that SFT-5 had more affinity for the CT-26 tumor than other samples the TPP ratio of which was lower. Consequently, we confirmed that TPP ligands affect target cancer cells more than FA, which means that cell membrane potential is significantly effective for tumor targeting.
Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats
Authors: Deba Farah , Ramos Kara , Vannoy Matthew , Munoz Kemburli , Akinola Lois S. , Damaj M. Imad , Hamouda Ayman K.
Published: June 2020

Neuronal nicotinic acetylcholine receptor (nAChR)-based therapeutics are sought as a potential alternative strategy to opioids for pain management. In this study, we examine the antinociceptive effects of 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole (CMPI), a novel positive allosteric modulator (PAM), with preferential selectivity to the low agonist sensitivity (α4)3(β2)2 nAChR and desformylflustrabromine (dFBr), a PAM for α4-containing nAChRs. We used hot plate and tail flick tests to measure the effect of dFBr and CMPI on the latency to acute thermal nociceptive responses in rats. Intraperitoneal injection of dFBr, but not CMPI, dose-dependently increased latency in the hot plate test. In the tail flick test, the effect achieved at the highest dFBr or CMPI dose tested was only <20% of the maximum possible effects reported for nicotine and other nicotinic agonists. Moreover, the coadministration of dFBr did not enhance the antinociceptive effect of a low dose of nicotine. Our results show that the direct acute effect of dFBr is superior to that for CMPI, indicating that selectivity to (α4)3(β2)2 nAChR is not advantageous in alleviating responses to acute thermal nociceptive stimulus. However, further studies are necessary to test the suitability of (α4)3(β2)2 nAChR-selective PAMs in chronic pain models.
Protective Effects of Some Grapevine Polyphenols against Naturally Occurring Neuronal Death
Authors: Lossi Laura , Merighi Adalberto , Novello Vittorino , Ferrandino Alessandra
Published: June 2020

The interest in the biological properties of grapevine polyphenols (PPs) in neuroprotection is continuously growing in the hope of finding translational applications. However, there are several concerns about the specificity of action of these molecules that appear to act non-specifically on the permeability of cellular membranes. Naturally occurring neuronal death (NOND) during cerebellar maturation is a well characterized postnatal event that is very useful to investigate the death and rescue of neurons. We here aimed to establish a baseline comparative study of the potential to counteract NOND of certain grapevine PPs of interest for the oenology. To do so, we tested ex vivo the neuroprotective activity of peonidin- and malvidin-3-O-glucosides, resveratrol, polydatin, quercetin-3-O-glucoside, (+)-taxifolin, and (+)-catechin. The addition of these molecules (50 μM) to organotypic cultures of mouse cerebellum explanted at postnatal day 7, when NOND reaches a physiological peak, resulted in statistically significant (two-tailed Mann–Whitney test—p < 0.001) reductions of the density of dead cells (propidium iodide+ cells/mm2) except for malvidin-3-O-glucoside. The stilbenes were less effective in reducing cell death (to 51–60%) in comparison to flavanols, (+)-taxifolin and quercetin 3-O-glucoside (to 69–72%). Thus, molecules with a -OH group in ortho position (taxifolin, quercetin 3-O-glucoside, (+)-catechin, and peonidin 3-O-glucoside) have a higher capability to limit death of cerebellar neurons. As NOND is apoptotic, we speculate that PPs act by inhibiting executioner caspase 3.
Effects of Dietary Protein on Body Composition in Exercising Individuals
Authors: Antonio Jose , Candow Darren G. , Forbes Scott C. , Ormsbee Michael J. , Saracino Patrick G. , Roberts Justin
Published: June 2020

Protein is an important component of a healthy diet and appears to be integral to enhancing training adaptations in exercising individuals. The purpose of this narrative review is to provide an evidence-based assessment of the current literature examining increases in dietary protein intake above the recommended dietary allowance (RDA: 0.8 g/kg/d) in conjunction with chronic exercise on body composition (i.e., muscle, fat and bone). We also highlight acute and chronic pre-sleep protein studies as well as the influence of exercise timing on body composition. Overall, a high-protein diet appears to increase muscle accretion and fat loss and may have beneficial effects on bone when combined with exercise. Pre-sleep protein is a viable strategy to help achieve total daily protein goals. Importantly, there appears to be no deleterious effects from a high-protein diet on muscle, fat or bone in exercising individuals.
Optics—Frontiers in Fundamental Research and Applications
Authors: Seeger Thomas
Published: June 2020

Optics are nowadays and in future an important part of many key scientific disciplines [...]
Antibacterial and Antibiofilm Activity of Myrtenol against Staphylococcus aureus
Authors: Cordeiro Laísa , Figueiredo Pedro , Souza Helivaldo , Sousa Aleson , Andrade-Júnior Francisco , Barbosa-Filho José , Lima Edeltrudes
Published: June 2020

The increase in Staphylococcus aureus resistance to conventional antibacterials and persistent infections related to biofilms, as well as the low availability of new antibacterial drugs, has made the development of new therapeutic alternatives necessary. Medicinal plants are one of the main sources of bioactive molecules and myrtenol is a natural product with several biological activities, although its antimicrobial activity is little explored. Based on this, the objective of this study was to evaluate the antibacterial activity of myrtenol against S. aureus, determining the minimum inhibitory and bactericidal concentrations (MIC and MBC), investigating the possible molecular target through the analysis of molecular docking. It also aimed to evaluate the effect of its combination with antibacterial drugs and its activity against S. aureus biofilms, in addition to performing an in silico analysis of its pharmacokinetic parameters. Myrtenol showed MIC and MBC of 128 µg/mL (bactericidal action) and probably acts by interfering with the synthesis of the bacterial cell wall. The effects of the association with antibacterials demonstrate favorable results. Myrtenol has remarkable antibiofilm activity and in silico results indicate a good pharmacokinetic profile, which make myrtenol a potential drug candidate for the treatment of infections caused by S. aureus.
In Vivo Assessment of Thermosensitive Liposomes for the Treatment of Port Wine Stains by Antifibrinolytic Site-Specific Pharmaco-Laser Therapy
Authors: Li Mingjuan , van Raath M. Ingmar , Khakpour Shervin , Seçilir Ahmet , Sliggers Bart C. , Huang Xuan , Ding Baoyue , Storm Gert , van der Hulst René R. , de Kroon Anton I.P.M. , Heger Michal
Published: June 2020

Antifibrinolytic site-specific pharmaco-laser therapy (SSPLT) is an experimental treatment modality for refractory port wine stains (PWS). Conceptually, antifibrinolytic drugs encapsulated in thermosensitive liposomes are delivered to thrombi that form in semi-photocoagulated PWS blood vessels after conventional laser treatment. Local release of antifibrinolytics is induced by mild hyperthermia, resulting in hyperthrombosis and complete occlusion of the target blood vessel (clinical endpoint). In this study, 20 thermosensitive liposomal formulations containing tranexamic acid (TA) were assayed for physicochemical properties, TA:lipid ratio, encapsulation efficiency, and endovesicular TA concentration. Two candidate formulations (DPPC:DSPE-PEG, DPPC:MPPC:DSPE-PEG) were selected based on optimal properties and analyzed for heat-induced TA release at body temperature (T), phase transition temperature (Tm), and at T > Tm. The effect of plasma on liposomal stability at 37 °C was determined, and the association of liposomes with platelets was examined by flow cytometry. The accumulation of PEGylated phosphocholine liposomes in laser-induced thrombi was investigated in a hamster dorsal skinfold model and intravital fluorescence microscopy. Both formulations did not release TA at 37 °C. Near-complete TA release was achieved at Tm within 2.0–2.5 min of heating, which was accelerated at T > Tm. Plasma exerted a stabilizing effect on both formulations. Liposomes showed mild association with platelets. Despite positive in vitro results, fluorescently labeled liposomes did not sufficiently accumulate in laser-induced thrombi in hamsters to warrant their use in antifibrinolytic SSPLT, which can be solved by coupling thrombus-targeting ligands to the liposomes.
Effects of Concentration and Temperature of Nutrient Solution on Growth and Camptothecin Accumulation of Ophiorrhiza pumila
Authors: Lee Ji-Yoon , Hiyama Miki , Hikosaka Shoko , Goto Eiji
Published: June 2020

The medicinal plant, Ophiorrhiza pumila, naturally grows on the floors of humid inland forests in subtropical areas. It accumulates camptothecin (CPT), which is used as an anti-tumor agent, in all organs. We investigated the optimal hydroponic root-zone environments for growth and CPT accumulation in O. pumila in a plant factory. In experiment 1, to determine the appropriate nutrient solution concentration (NSC), O. pumila was cultivated using four concentrations (0.125, 0.25, 0.5, and 1.0 times) of a commercial solution for 63 days after the start of treatment (DAT). The electrical conductivity of these NSCs was 0.6, 0.9, 1.5, and 2.7 dS m−1, respectively. The total dry weights at 0.25 and 0.5 NSCs were higher than those at the other two NSCs. CPT content at 0.25 NSC was significantly higher than those at other NSCs. In experiment 2, to investigate an appropriate nutrient solution temperature (NST), O. pumila was cultivated at four NSTs (10, 20, 26, and 35 °C, named as T10, T20, T26, and T36, respectively) for 35 DAT. The growth and CPT content at T20 was the highest among the treatments. Therefore, root-zone environments of 0.25 NSC and 20 °C of NST produced the best growth and CPT accumulation in O. pumila.
Heterogenized Imidazolium-Based Ionic Liquids in Pebax®Rnew. Thermal, Gas Transport and Antimicrobial Properties
Authors: Clarizia Gabriele , Bernardo Paola , Carroccio Sabrina C. , Ussia Martina , Restuccia Cristina , Parafati Lucia , Calarco Anna , Zampino Daniela
Published: June 2020

Imidazolium-based ionic liquids (ILs) have interesting antimicrobial activity and their inclusion in a flexible film is ideal to take advantage of their properties in practical applications. Poly(ether-block-amide) (Pebax®Rnew) films were prepared by solution casting, loading two synthetized ILs (1-hexadecyl-3-methylimidazolium dimethyl-5-sulfoisophthalate [Hdmim][DMSIP], IL1 and 1-octyloximethyl-3-methylimidazolium hexafluorophosphate [OOMmim][PF6], IL2) up to 5 wt.%. The ILs were characterized by 1H NMR and MALDI-TOF spectroscopy. The films were investigated for miscibility, morphology, wettability, spectral properties and gas transport. The films display a good thermal stability (>200 °C). Differential scanning calorimetry (DSC) proves phase separation in the blends, that is consistent with FTIR analysis and with the island-like surface morphology observed in the micrographs. Gas permeability tests revealed that the IL-loaded films are dense and poreless, keeping the selectivity of the polymer matrix with a somewhat lessened permeability owing to the impermeable ILs crystals. The film antimicrobial activity, evaluated against Gram-negative and Gram-positive bacterial strains, was correlated to the structure of the incorporated ILs. The smaller IL2 salt did not modify the hydrophobic nature of the neat polymer and was readily released from the films. Instead, IL1, having a longer alkyl chain in the cation, provided a promising antimicrobial activity with a good combination of hydrophilicity, permeability and thermal stability.
Youth Ministry after the Synod on Young People—Ten Points of No Return
Authors: Sala Rossano
Published: June 2020

From October 2016 to March 2019, the Catholic Church engaged in a lengthy journey together with young people. Over these two and a half years, some important documents were produced, including the Post-Synodal Apostolic Exhortation Christus Vivit by Pope Francis. The Synod on Youth has involved the entire Catholic Church, mobilizing all Church communities around the world. After explaining the identity and meaning of a Synod for the Catholic Church, the author offers ten points of no return, which are to be considered the main fruits of this journey. They are leaven for the renewal of youth ministry in the Catholic context and elements for further exploration, comparison and dialogue with other Christian denominations.
Social License to Operate in Mining: Present Views and Future Trends
Authors: Komnitsas Konstantinos
Published: June 2020

The social license to operate (SLO) is an informal social contract that aims to bridge the gap among the views of the most important stakeholders involved in mining activities. The novelty of this paper lies in the fact that it discusses the current situation and the future prospects of granting a SLO, mainly at the European Union (EU) level, by considering the mine of the future, in terms of deep sea and landfill mining, and the criticality of raw materials that are required by high tech products as well as by emerging and green technologies. Also, it highlights the factors that may affect the views of all involved stakeholders, focusing on the joint efforts that are required by the industry and the society as well as on the main technological, social, political and legal issues which are relevant to the process. It is believed that if trust is developed between the involved stakeholders the SLO may prove an important tool in future mining in order to safeguard the supply of raw materials, minimize the environmental footprint and improve the quality of life in the affected regions. Finally, a conceptual flowsheet involving the main steps that may be followed for granting a SLO is proposed.
Fast Approximation of Over-Determined Second-Order Linear Boundary Value Problems by Cubic and Quintic Spline Collocation
Authors: Seiwald Philipp , Rixen Daniel J.
Published: June 2020

We present an efficient and generic algorithm for approximating second-order linear boundary value problems through spline collocation. In contrast to the majority of other approaches, our algorithm is designed for over-determined problems. These typically occur in control theory, where a system, e.g., a robot, should be transferred from a certain initial state to a desired target state while respecting characteristic system dynamics. Our method uses polynomials of maximum degree three/five as base functions and generates a cubic/quintic spline, which is C 2 / C 4 continuous and satisfies the underlying ordinary differential equation at user-defined collocation sites. Moreover, the approximation is forced to fulfill an over-determined set of two-point boundary conditions, which are specified by the given control problem. The algorithm is suitable for time-critical applications, where accuracy only plays a secondary role. For consistent boundary conditions, we experimentally validate convergence towards the analytic solution, while for inconsistent boundary conditions our algorithm is still able to find a “reasonable” approximation. However, to avoid divergence, collocation sites have to be appropriately chosen. The proposed scheme is evaluated experimentally through comparison with the analytical solution of a simple test system. Furthermore, a fully documented C++ implementation with unit tests as example applications is provided.
The Evolution of Wide-Area DInSAR: From Regional and National Services to the European Ground Motion Service
Authors: Crosetto Michele , Solari Lorenzo , Mróz Marek , Balasis-Levinsen Joanna , Casagli Nicola , Frei Michaela , Oyen Anneleen , Moldestad Dag Anders , Bateson Luke , Guerrieri Luca , Comerci Valerio , Andersen Henrik Steen
Published: June 2020

This study is focused on wide-area deformation monitoring initiatives based on the differential interferometric SAR technique (DInSAR). In particular, it addresses the use of advanced DInSAR (A-DInSAR) techniques, which are based on large sets of synthetic aperture radar (SAR) and Copernicus Sentinel-1 images. Such techniques have undergone a dramatic development in the last twenty years: they are now capable to process big sets of SAR images and can be exploited to realize a wide-area A-DInSAR monitoring. The study describes several initiatives to establish wide-area ground motion services (GMS), both at county- and region-level. In the second part of the study, some of the key technical aspects related to wide-area A-DInSAR monitoring are discussed. Finally, the last part of the study is devoted to the European ground motion service (EGMS), which is part of the Copernicus land monitoring service. It represents the most important wide-area A-DInSAR deformation monitoring system ever developed. The study describes its main characteristics and its main products. The end of the production of the first EGMS baseline product is foreseen for the last quarter of 2021.
Temperature and Emissivity Separation ‘Draping’ Algorithm Applied to Hyperspectral Infrared Data
Authors: Lombardo Valerio , Pick Leonie , Spinetti Claudia , Tadeucci Jacopo , Zakšek Klemen
Published: June 2020

In the presented work, the spectral emissivity of basaltic melts at magmatic temperatures was retrieved in a laboratory-controlled experiment by measuring their spectral radiance. Granulated bombs of Etnean basalts were melted and the radiant energy from the melting surface was recorded by a portable spectroradiometer in the short wavelength infrared (SWIR) spectral range between 1500 and 2500 nm. The Draping algorithm, an improved algorithm for temperature and emissivity separation, was applied for the first time to SWIR hyperspectral data in order to take into account the non-uniform temperature distribution of the melt surface and, at the same time, solving the two temperatures and the spectral emissivity. The results have been validated by comparing our results with the emissivity measured at a "lava simulator". Basalt spectral emissivity does not vary significantly at magmatic temperature, but shows an absorption feature in the range 2180–2290 nm, an atmospheric window pivotal for the IR remote sensing of active volcanoes.
Real-Time Estimation of Low Earth Orbit (LEO) Satellite Clock Based on Ground Tracking Stations
Authors: Yang Zhixin , Liu Hui , Qian Chuang , Shu Bao , Zhang Linjie , Xu Xintong , Zhang Yi , Lou Yidong
Published: June 2020

The rapid movement of low Earth orbit (LEO) satellite can improve geometric diversity, which contributes to the rapid convergence of Global Navigation Satellite System (GNSS) precise point positioning (PPP). However, the LEO onboard receiver clock cannot be used directly by PPP users as the LEO satellite clock because the LEO onboard receiver clock and LEO satellite clock absorb different code delays when receiving and transmitting signals. In this study, a real-time estimation approach for the LEO satellite clock based on ground tracking stations was proposed for the first time. The feasibility for the rapid convergence of the LEO satellite clock was analyzed using the satellite time dilution of precision (TDOP) that one satellite is relative to multiple ground tracking stations. The LEO constellation of 168 satellites and observations for 15 ground tracking stations were simulated to verify the proposed method. The experiment results showed that the average convergence time was 31.21 min for the Global Positioning System (GPS) satellite clock, whereas the value for the LEO satellite clock was only 2.86 min. The average root mean square (RMS) and standard deviation (STD) values after convergence were 0.71 and 0.39 ns for the LEO satellite clock, whereas the values were 0.31 and 0.13 ns for the GPS satellite clock. The average weekly satellite TDOP for the LEO satellite was much smaller than that for the GPS satellite. The average satellite TDOPs for all LEO and GPS satellites were 19.13 and 1294.70, respectively. However, the average delta TDOPs caused by satellite motion for all LEO and GPS satellites were both 0.10. Therefore, the rapid convergence of the LEO satellite clock resulted from the better geometric distribution of the LEO satellite relative to ground stations. Despite errors and the convergence time of the LEO satellite clock, the convergence time and positioning accuracy for LEO-augmented GPS and BeiDou Navigation Satellite System (BDS) PPP with the real-time estimated LEO satellite clock can still reach 10.63 min, 1.94 cm, 1.44 cm, and 4.18 cm in the east, north, and up components, respectively. The improvements caused by LEO satellite for GPS/BDS PPP were 59%, 30%, 31%, and 33%, respectively.
A Robust and Versatile Pipeline for Automatic Photogrammetric-Based Registration of Multimodal Cultural Heritage Documentation
Authors: Pamart Anthony , Morlet François , De Luca Livio , Veron Philippe
Published: June 2020

Imaging techniques and Image Based-Modeling (IBM) practices in the field of Cultural Heritage (CH) studies are nowadays no longer used as one-shot applications but as various and complex scenarios involving multiple modalities; sensors, scales, spectral bands and temporalities utilized by various experts. Current use of Structure from Motion and photogrammetric methods necessitates some improvements in iterative registration to ease the growing complexity in the management of the scientific imaging applied on heritage assets. In this context, the co-registration of photo-documentation among other imaging resources is a key step in order to move towards data fusion and collaborative semantic enrichment scenarios. This paper presents the recent development of a Totally Automated Co-registration and Orientation library (TACO) based on the interoperability of open-source solutions to conduct photogrammetric-based registration. The proposed methodology addresses and solves some gaps in term of robustness and versatility in the field of incremental and global orientation of image-sets dedicated to CH practices.
A Methodology for Comparing the Surface Urban Heat Island in Selected Urban Agglomerations Around the World from Sentinel-3 SLSTR Data
Authors: Sobrino José Antonio , Irakulis Itziar
Published: June 2020

Retrieval of land surface temperature (LST) from satellite data allows to estimate the surface urban heat island (SUHI) as the difference between the LST obtained in the urban area and the LST of its surroundings. However, this definition depends on the selection of the urban and surroundings references, which translates into greater difficulty in comparing SUHI values in different urban agglomerations across the world. In order to avoid this problem, a methodology is proposed that allows reliable quantification of the SUHI. The urban reference is obtained from the European Space Agency Climate Change Initiative Land Cover and three surroundings references are considered; that is, the urban adjacent (Su), the future adjacent (Sf), and the peri-urban (Sp), which are obtained from mathematical expressions that depend exclusively on the urban area. In addition, two formulations of SUHI are considered: SUHIMAX and SUHIMEAN, which evaluate the maximum and average SUHI of the urban area for each of the three surrounding references. As the urban population growth phenomenon is a world-scale problem, this methodology has been applied to 71 urban agglomerations around the world using LST data obtained from the sea and land surface temperature radiometer (SLSTR) on board Sentinel-3A. The results show average values of SUHIMEAN of (1.8 ± 0.9) °C, (2.6 ± 1.3) °C, and (3.1 ± 1.7) °C for Su, Sf, and Sp, respectively, and an average difference between SUHIMAX and SUHIMEAN of (3.1 ± 1.1) °C. To complete the study, two additional indices have been considered: the Urban Thermal Field Variation Index (UFTVI) and the Discomfort Index (DI), which proved to be essential for understanding the SUHI phenomenon and its consequences on the quality of life of the inhabitants.
Real-Time Moving Object Detection in High-Resolution Video Sensing
Authors: Zhu Haidi , Wei Haoran , Li Baoqing , Yuan Xiaobing , Kehtarnavaz Nasser
Published: June 2020

This paper addresses real-time moving object detection with high accuracy in high-resolution video frames. A previously developed framework for moving object detection is modified to enable real-time processing of high-resolution images. First, a computationally efficient method is employed, which detects moving regions on a resized image while maintaining moving regions on the original image with mapping coordinates. Second, a light backbone deep neural network in place of a more complex one is utilized. Third, the focal loss function is employed to alleviate the imbalance between positive and negative samples. The results of the extensive experimentations conducted indicate that the modified framework developed in this paper achieves a processing rate of 21 frames per second with 86.15% accuracy on the dataset SimitMovingDataset, which contains high-resolution images of the size 1920 × 1080.
Doubly Covariance Matrix Reconstruction Based Blind Beamforming for Coherent Signals
Authors: Xie Zhuang , Fan Chongyi , Zhu Jiahua , Huang Xiaotao
Published: June 2020

This paper proposes a beamforming method in the presence of coherent multipath arrivals at the array. The proposed method avoids the prior knowledge or estimation of the directions of arrival (DOAs) of the direct path signal and the multipath signals. The interferences are divided into two groups based on their powers and the interference-plus-noise covariance matrix (INCM) is reconstructed through the doubly covariance matrix reconstruction concept. The composite steering vector (CSV) that accounts for the direct path signal and multipath signals is estimated as the principal eigenvector of the sample covariance matrix with interferences and noise removed. The optimal weight vector is finally computed using the INCM and the CSV. The proposed method involves no spatial smoothing and avoids reduction in the degree of freedom. Simulation results demonstrate the improved performance of the proposed method.
Possibility of Increasing the Growth and Photosynthetic Properties of Precocious Walnut by Grafting
Authors: Bai Yongchao , Zhang Junpei , Wu Yue , Huang Ruimin , Chang Yingying , Lei Xiashuo , Song Xiaobo , Pei Dong
Published: June 2020

Plant growth characteristics after grafting are mainly dependent on photosynthesis performance, which may be influenced by grafting combinations with different rootstocks and scions. In this study, we used one-year-old walnut grafts to investigate the grafting compatibility between precocious (‘Liaoning 1’, L) and hybrid (‘Zhong Ning Sheng’, Z) walnut, as well as rootstock and scion impact on the growth and photosynthetic properties of walnut trees. The results showed that grafting compatibility between the two varieties is high, with survival rates upward of 86%. Overwintering survival of grafted seedlings was as high as 100%, which indicated that the allopolyploid had good resistance to low-temperature stress. The homograft of the hybrid walnut had the highest net photosynthesis rate (18.77 μmol·m−2s−1, Z/Z) and growth characteristics, which could be due to its higher transpiration rate and stomatal conductance, whereas the homograft of precocious walnut presented the lowest net photosynthesis rate (15.08 μmol·m−2s−1, L/L) and growth characteristics. Significant improvements in the net photosynthesis rate (15.97 and 15.24 μmol·m−2s−1 for L/Z and Z/L, respectively) and growth characteristics of precocious walnut were noticed during grafting of the hybrid walnut, which could have been contributed by their transpiration rate. The results of this study serve as a guide for the selection and breeding of good rootstock to improve plant growth characteristics and photosynthetic efficiency. We conclude that good rootstock selection improves plant growth potential and could play an important role in sustainable production.
Deep Recurrent Convolutional Neural Network for Bankruptcy Prediction: A Case of the Restaurant Industry
Authors: Becerra-Vicario Rafael , Alaminos David , Aranda Eva , Fernández-Gámez Manuel A.
Published: June 2020

Using logistic regression technique and Deep Recurrent Convolutional Neural Network, this study seeks to improve the capacity of existing bankruptcy prediction models for the restaurant industry. In addition, we have verified, in the review of existing literature, the gap in the research of restaurant bankruptcy models with sufficient time in advance and that only companies in the restaurant sector in the same country are considered. Our goal is to build a restaurant bankruptcy prediction model that provides high accuracy, using information distant from the bankruptcy situation. We had a sample of Spanish restaurants corresponding to the 2008–2017 period, composed of 460 solvent and bankrupt companies, for which a total of 28 variables were analyzed, including some of a non-financial nature, such as age of restaurant, quality, and belonging to a chain. The results indicate that the best bankruptcy predictors are financial variables related to profitability and indebtedness and that Deep Recurrent Convolutional Neural Network exceeds logistic regression in predictive capacity.
The Mission-Oriented Approach for (Cross-Border) Regional Development
Authors: Cappellano Francesco , Kurowska-Pysz Joanna
Published: June 2020

During the times of the COVID-19 pandemic, nations have issued unprecedented border closures around the world, yielding abrupt impacts on the movement of goods and people. This has heavily affected the quality of life in border regions, which are often found to be at a disadvantage when compared to other regions in terms of employment, accessibility, social services and economic growth. Based upon developing threads in the literature concerning the untapped potential for development in border regions, we argue that the Mission-Oriented Approach (MOA) can fit well with the ambitious goal to revitalize those territories in the aftermath of the pandemic. Despite the surge of MOA in discourses on innovation policy, we seek to implement it in a regional development perspective, pursuing both economic and social policy objectives. The authors unravel the policy concept of MOA into three main aspects: (I) address a sound societal challenge; (II) Research & Development (R&D) regional agenda embedded in a cross-border regional development vision; (III) mobilizing multiple cross-sectorial projects. Through a desk study analysis, the authors draw insights from selected case studies where these aspects have been implemented to inspire policy intervention in the aftermath of COVID-19. This paper presents the MOA theoretical model, which has potential explanatory power in other cross-border regions.
The Experimental Study of the Utilization of Recycling Aggregate from the Demolition of Elements of a Reinforced Concrete Hall
Authors: Kalinowska-Wichrowska Katarzyna , Suescum-Morales David
Published: June 2020

The article shows a case study as to whether the thermal and mechanical recycling of concrete is suitable for concrete debris from the demolition of structural elements of a 30-year-old industrial hall. The experiment included 10 series of new composites made from heated recycled concrete aggregate (HRCA) subjected to different variants of heat treatment and one additional control series with only natural aggregate (NA). The compressive strength of the new concretes has been determined. The microscopic observations of HRCA have also been made. The test results revealed that proper heat treatment of concrete rubble makes it possible to obtain a high-quality recycled coarse aggregate, which can be used as a 100% replacement for natural coarse aggregates in new concretes.
Experimental Study of the Crack Predominance of Rock-Like Material Containing Parallel Double Fissures under Uniaxial Compression
Authors: Chen Wei , Wan Wen , Zhao Yanlin , Peng Wenqing
Published: June 2020

Fractured rock mass is a relatively complex medium in nature. It plays a key role in various projects, such as geotechnical engineering, mining engineering and tunnel engineering. Especially, the interaction between fissures has a practical function in the guidance of safe production. This paper takes its research object as rock-like material which contains prefabricated parallel double fissures. It studies how the fissures’ length difference and spacing influence the failure of specimens under uniaxial compression, and analyzes them with fracture mechanics theory. The results include two aspects. Firstly, no matter how the length difference and spacing change, the upper fissure always generates new cracks. Secondly, the length difference and spacing produce three effects on the lower fissure. (1) The fissure propagates less obviously as the length difference increases. With the increase to 40mm, the propagation does not occur at all. (2) The decrease of spacing weakens the propagation. As it is reduced to 5 mm, the propagation stops. (3) The crack propagation is more sensitive to length difference than spacing. Regardless of spacing changes, if a length difference is large enough (40 mm or more), the new crack does not expand, while if it is small enough (10 mm or less), propagation always appears.
Discovering the Role of Emotional and Rational Appeals and Hidden Heterogeneity of Consumers in Advertising Copies for Sustainable Marketing
Authors: Kim Cheong , Jeon Hyeon Gyu , Lee Kun Chang
Published: June 2020

Advertising copies have been considered as a fundamental strategy for firms to continue sustainable marketing strategies. In order to provide the advancement of previous research and practical implication to marketers in the field for sustainable marketing strategy, this research tried to reveal the role of emotional and rational appeals as well as hidden heterogeneity of consumers in the appeal–value–trust–satisfaction–WOM framework. By applying the PLS-SEM and PLS-POS approach to 230 valid questionnaire samples, we could discover the role of appeals in the framework as well as three types of unobserved heterogeneity among the respondents. Both emotional and rational appeals had significant influences on the value–satisfaction–trust–WOM context. In addition, for hidden consumer traits in advertising copies, we revealed three types of consumer groups: Type 1, the consumer group with a rational orientation (n = 68); Type 2, the group with an emotional orientation (n = 74) and Type 3, the group with a utilitarian orientation. This research provided contributions by offering some insight into ways to establish sustainable marketing strategies in advertisements and to address unobserved heterogeneity consumers in advertising copy appeals.
Social Economy, Gender Equality at Work and the 2030 Agenda: Theory and Evidence from Spain
Authors: Castro Núñez Rosa , Bandeira Pablo , Santero-Sánchez Rosa
Published: June 2020

The improvement in women’s labor conditions and the elimination of segregation and other forms of direct or indirect discrimination have become one of the major challenges of the international political agenda, and as so have been included in the Sustainable Development Goals (SDGs) launched by the UN in the 2030 Agenda for Sustainable Development. At the same time, there is an increasing interest in the effects that the Social Economy (SE) might have on the achievement of the SDGs, as a consequence of its distinguishing of people-oriented principles. The goal of this paper is to analyze the specific contribution of SE entities to the reduction of gender inequalities in the labor market. We conduct an impact analysis with quasi-experimental counterfactual techniques, in which we compare one experimental group (the SE) with a control group (profit-seeking firms) using labor data from Spain for the period 2008–2017. The results indicate that social economy entities significantly contribute to the achievement of SDGs 5, 8 and 10, showing higher female participation, more stable jobs, and a lower degree of the glass-ceiling phenomenon.