bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of Protoporphyrin in Plasma and Suction-Blister Fluid from Light-Irradiated and Non-Irradiated Skin in Protoporphyria Patients
Authors: Wiersema-van Gog H. , de Wilde-Verburg M.W. , Suurmond D.
Published: October 2009

At various times of the year the protoporphyrin level in the plasma of 11 patients with erythropoietic protoporphyria was determined. In the winter as well as in the summer, when the patients received carotenoids, an area on one forearm of 10 patients was irradiated with artificial (xenon arc) light, after which suction blisters were made on both forearms. Protoporphyrin levels were determined in the plasma and in the blister fluid from both areas. Suction-blister fluid was considered representative of the interstitial fluid in the dermis. In the winter the protoporphyrin levels of the blister fluid from the irradiated area were significantly higher than in the fluid from the non-irradiated area. In the summer this difference was not significant. The possible implications of these findings are discussed.
Dermite du siège en W chez le nourrisson
Authors: Larrègue M. , Gallet P. , Rat J.P. , Bressieux J.M.
Published: October 2009

The W-shaped napkin rash affects mainly the convex parts of the perianal region of infants, avoiding the folds and perianal cleft. The dermatitis is of traumatic origin due to the friction of paper napkins. It heals under antiseptic treatment on condition that the use of paper napkins and rubber pants, which cause occlusion, is stopped temporarily.
Analyses in Blood of Dermatological Patients
Authors: Seutter E. , Colsen Maria Louise J. , van de Staak W.J.B.M. , Seutter-Berlage Francisca
Published: October 2009

Glutathione was estimated in 98 blood samples from dermatological patients; in only two cases, both of contact eczema, a value considerably below normal was found. Glutathione reductase was assayed in blood samples from 139 different patients and 21 normal controls. The activity was significantly higher in atopic dermatitis (17patients). A significantly greater variability was found among patients with non methotrexate-treated psoriasis (44), light sensitivity (12) and scleroderma (5). In the methotrexate-treated psoriatic group (24) the mean and variability did not differ significantly from normal. In most hospitalized patients a low glutathione reductase activity rose within a few weeks, but in a case of dermatitis herpetiformis a very low level persisted for 3 months. Blood samples with very low glutathione reductase activity, taken from a case of psoriasis and from a patient on griseofulvin treatment, gave a positive peroxide test and tended to hemolyze; these returned to normal together with the glutathione reductase activity.
Membrandefekt als Basis der gestörten Wachstumsregulation bei Psoriasis
Authors: Orfanos C.E. , Mahrle G.
Published: October 2009

The system glycocalyx – membrane bound enzymes – cAMP may be regarded as a regulatory mechanism for the control of epidermal growth. The glycocalyx of the epithelial cell membrane is obviously a receptor and accumulator for agents stimulating adenyl cyclase and other membrane-bound enzymes of energy utilisation; cAMP, on the other hand, serves as an intracellular ‘mediator’ between proliferative stimuli and the DNA of the keratinocytes. Numerous cytological, cytochemical, and enzymatic biochemical studies indicate that this mechanism is profoundly disturbed in psoriasis, particularly at the membrane-bound stage.
Woolly Hair Naevus with Ocular Involvement
Authors: Jacobsen Keld Urup , Lowes Martin
Published: October 2009

A case of woolly hair naevus with ocular involvement is presented. The subgroups of the woolly hair disease are reviewed. It is suggested that patients with woolly hair should have a full eye examination.
Sun and Skin
Authors: Jung Ernst G.
Published: October 2009

Sunlight is the main environmental factor influencing human skin. The sun-light’s terrestrial spectrum is different from the extraterrestrial one, sunlight being changed by the filter effect of ozone and particles in the stratosphere and atmosphere. Attention is drawn to the influence of ‘supersonic transporters’ (SST) and chlorofluoromethanes on this protective ozone shield. The cascade of events which occur in human skin after sun exposure are schematically listed. The mechanisms of protection and the processes of adaptation including their respective values are presented. An overexposure induces acute clinical symptoms and leads, as a late effect, to potential malignancies.
Immunohistological Development of the Kveim Reaction
Authors: Hannuksela Matti , Salo Osmo P. , Karvonen Jaakko
Published: October 2009

A follow-up of immunohistological events of Kveim reactions was made by taking biopsies from Kveim test sites at various intervals. Immunoglobulins were present in one half of the specimens taken at 2-7 days, but not earlier. 2-week-old reactions showed immunoglobulins in 50% of the cases and older reactions in 79%. Out of 52 specimens examined with specific conjugates, IgM was demonstrated in 42, IgG in one, and IgA in one reaction. Complement (C3) was seen in 83% out of 47 specimens examined. Complement and immunoglobulins were found in vessel walls but not elsewhere in the tissues.
Provocation Tests with Antiphlogistica and Food Additives in Recurrent Urticaria
Authors: Thune P. , Granholt A.
Published: October 2009

100 patients (53 women, 47 men) suffering from recurrent urticaria were tested with different food additives such as 8 dye additives, 7 preservatives and 7 antiphlogistica. In total did 62 patients react with urticaria and/or angio-oedema. 39 patients had reactions to two or more substances while 23 patients reacted to only one substance. Reactions were induced most frequently by aspirin (27/80), dextropropoxyphene (11/45) and the azo dyes tartrazin (20/96) and sunset yellow (13/86). Asthmatic symptoms occurred in 3 and purpura in 2 patients. 13 patients out of 100 reported of immediate reactions to different foods.
Le granulome annulaire perforant
Authors: Gattlen J.M. , Delacrétaz J.
Published: October 2009

Report of 5 personal observations of perforating granuloma anulare with a review of the literature and a short discussion of the implicated process of transepidermal elimination.
Inflammatory Linear Verrucose Epidermal Nevus
Authors: Toribio J. , Quiñones P.A.
Published: October 2009

A typical case of inflammatory linear verrucose epidermal nevus (ILVEN), with quite a psoriasiform histologic pattern, is reported. Intralesionally administered paramethasone acetate caused a temporary suppression of the clinical and histopathologic inflammatory features. The concept of ILVEN is briefly discussed.
Genetics and Dermatology
Authors: Schnyder U.W.
Published: October 2009

An attempt has been made to show and discuss today’s problems of geno-dermatology, mentioning the important groups of the heterogenous diseases and enzyme defects which are coupled with the skin diseases. Moreover, the chromosomes breakage syndromes are reviewed. To a great extent, these problems are of theoretical interest, but the genetic counselling is on the increase and already plays an important part in the daily routine of the large hospitals.
Behçet’s Disease: Etiology and Treatment
Authors: Haim S.
Published: October 2009

The etiology and treatment of Behçet’s diseases are still undecided. There are three principal etiological hypotheses: viral, autoimmune and defective fibrinolytic activity. Accordingly, antiviral, immunosuppressive and fibrinolytic enhancing agents have been tried. Corticosteroids, however, still constitute conventional therapy. Follow-up of cases has so far revealed that none of the above therapeutic measures fundamentally alters the course of the disease, and serious complications may occur and progress during their administration.
Trichophyton rubrum Infection of the Penis
Authors: Pillai K.G. , Singh G. , Sharma B.M.
Published: October 2009

Dermatomycosis is a common disease of skin. It usually involves groin, trunk, hands, feet and hair. But involvement of the penis is not known. Two cases of T. rubrum infection of the penis are reported and the possible causative factors are discussed.
Sweating in the ‘Anhidrotic Type’ of Congenital Ectodermal Dysplasia
Authors: Shoenfeld Y. , Shapiro Y. , Fisher B.K. , Dvoretzky I.
Published: October 2009

Whole body sweat rate in two brothers suffering from congenital ectodermal dysplasia (CED) was measured. At a moderate heat load (DBT 30°C and 50% relative humidity) we found no apparent weight loss due to sweating. At a higher heat load (DBT 36°C, 50% relative humidity) sweating was observed, but only at levels approximately two thirds of those observed in normal controls. In the light of these experimental results, we support the suggestion that the nomenclature for CED patients should be changed. Instead of the present classification of anhidrotic CED and hidrotic CED, it is suggested that the terms hypohidrotic and hidrotic be substituted.
Metaplasia of a Verruca vulgaris into Spinocellular Carcinoma
Authors: Grussendorf Elke-Ingrid , Gahlen Walther
Published: October 2009

Histomorphological description of the transformation of a verruca vulgaris into squamous cell carcinoma. Discussion of the oncogenesis by virus.
Incontinentia Pigmenti et Achromians
Authors: Mittal Radha , Handa F. , Sharma Subhash Chander
Published: October 2009

A case is reported, apparently the first of its kind in the literature, of a female child in which there were not only pigmented lesions of incontinentia pigmenti but also hypopigmented lesions of incontinentia pigmenti achromians. The title incontinentia pigmenti et achromians is suggested for this combined disorder. The child also had associated lesions in the form of nail dystrophy, delayed dentition and epilepsy.
Vitamin A Acid in the Topic Treatment of Plantar Warts
Authors: de Bersaques J.
Published: October 2009

An ointment with 2% vitamin A acid was applied under occlusion to 50 patients with plantar warts. Only 17 could be considered as cured after 2–10 weeks of treatment.
Lichen planus pigmentosus
Authors: Bhutani L.K. , Bedi T.R. , Pandhi R.K. , Nayak N.C.
Published: October 2009

Clinical and histological features in 40 patients of a pigmentary disorder, hitherto undescribed in Indians, are presented. The resemblance of this entity to somewhat similar disorders seen in other parts of the world and its possible relation to lichen planus is discussed.
Vor- und Nachteile des Peroxidase-Tests mit Treponema pallidum in der Serodiagnostik von Syphilis im Vergleich mit dem FTA-ABS-Test
Authors: Pospíšil L. , Kratochvil F.
Published: October 2009

Advantages and disadvantages of the peroxidase test with Treponema pallidum and the FTA-ABS test were compared. The results were veryfied through the TPI test. Sera from diseased patients suffering from various forms of syphilis, from patients with other clinical histories and from a group of (relatively) healthy persons (blood donors) were the object of the examinations. An absolute conformity of the peroxidase and FTA reaction was attained in 87.5% of cases. The authors analyzed the advantages and disadvantages of both reactions and concluded that the peroxidase reaction can be carried out only in highly specialized laboratories and therefore does not represent a dramatic back-up of the routine diagnostics of syphilis.
Das Knoblauchzehenfibrom
Authors: Undeutsch W. , Schieferstein G.
Published: October 2009

A peculiar, triform fibromatosis on the dorsum of the distal limb of the 4th toe in a 27-year-old female student is reported. These tumors – corresponding to their outer shape – have been described as garlic-clove fibroma in American scientific publications. Their origin seems to be related to a specific reaction of the nail bed or of the matrix of the nail caused by a chronic irritation.
Die DNS-Synthese in der Epidermis nach Kontakt mit Harnstoff
Authors: Wohlrab W.
Published: October 2009

The thinning of epidermis after urea treatment is explicable theoretically in several ways. We take the estimation of epidermal DNA synthesis measured autoradiographically by 3H-thymidine incorporation for a valid contribution to solve this question. As a result, the number of labeled nuclei in the stratum basale from ears of guinea pigs was decreased after a 5-day influence of urea down to half the number in untreated controls. Comparing the conclusions from these results and from biometric measurements, a further epidermal disturbance may easily be supposed in a lengthened life-time of postmitotic epidermal cells after contact with urea. There is no evidence whether these changes are either due directly to the influence of urea or only a secondary effect.
Nodular Tenosynovitis
Authors: Baes H. , Tanghe W.
Published: October 2009

The authors report a typical case of nodular tenosynovitis or benign giant cell synovioma of the right ring-finger of a 53-year-old woman. Histologically, this tumor is characterized by a highly cellular proliferation of histiocytie- and fibrocytie-like cells, closely resembling synovial cells, intermingled with multinucleated giant cells, hemosiderin- and lipid-laden cells.
Ichthyosis linearis circumflexa Comèl with Trichorrhexis invaginata (Netherton’s Syndrome)
Authors: Mevorah B. , Frenk E.
Published: October 2009

Skin biopsies from three cases of clinically typical ichthyosis linearis circumflexa Comèl with trichorrhexis invaginata and manifestations of atopy revealed characteristic, previously undescribed histological alterations at the active border of figurate lesions: formation of an eosinophilic, PAS-positive material replacing the lamellar stratum corneum.
EosinophiIic Pustular Folliculitis (Ofuji)
Authors: Ishibashi A. , Nishiyama Y. , Miyata C. , Chujo T.
Published: October 2009

Three cases of eosinophilic pustular folliculitis (Ofuji) are reported. The condition is characterized by follicular, tiny red papules with formation of pustules on fairly well-defined, slightly indurated erythematous plaques. The lesions have a tendency to central healing and peripheral extension, and are asymmetrically distributed on the face, the back, the arms, and sometimes the palms and/or soles. The condition proceeds with remissions and exacerbations. Histological features are pustular folliculitis from the ostium to the sebaceous gland, chiefly composed of polymorphs and eosinophiles.
Subcellular Distribution and Cytoplasmatic Kinetic Properties of Acid Phosphatase of Normal Stratum Corneum and Psoriatic Scales
Authors: Förster F.J. , Kallenberg L. , Fertig U. , Leonhardi G.
Published: October 2009

The specific and total acid phosphatase activities of all fractions of a differential centrifugation of homogenized normal stratum corneum and psoriatic scales were compared. The main enzyme activities of both tissues were localized in the 105,000 g supernatants, i.e. the cytoplasmatic fractions. The kinetic properties of the cytoplasmatic acid phosphatase of both tissues were studied and the influence of several inhibitors investigated. The enzymes in both tissues could be inhibited by p-chloromercuribenzoate, F––, tartrate, Be2+, Cu2+, and Zn2+. Pb2+ only affected the psoriatic enzyme.
A Case of Growth Retardation and Cushing’s Syndrome Due to Excessive Application of Betamethasone-17-Valerate Ointment
Authors: Vermeer B.J. , Heremans G.F.P.
Published: October 2009

An 8-year-old girl with severe proportional growth retardation and Cushing’s syndrome with excessive osteoporosis due to excessive application of corticosteroids is presented. The adrenal function became normal and Cushing’s syndrome disappeared gradually after cessation of the betamethasone application; growth amounted to 11 cm in 9 months, corresponding with a growth rate of 15 cm/year. It is recommended that the growth of children who are treated topically with large amounts of corticosteroids for a period longer than 3 months be checked frequently.
β-Carotene Treatment of Polymorphous Light Eruptions
Authors: Jansén Christer T.
Published: October 2009

The photoprotective effect of peroral β-carotene medication was evaluated on 66 patients suffering from polymorphous light eruptions. With a dosage of 75 mg/day, 51 of the patients responded favourably, as judged clinically. 55 of the patients noted that their threshold tolerance to sunlight was elevated during β-carotene treatment, in some patients even with a factor of 20–30. The average increase in sun tolerance was with a factor of about 8. The therapeutic effect of β-carotene was dose-dependent. Some degree of sun exposure seemed to be necessary for the photoprotective effect to evolve optimally. The photoprotection gradually became evident in a couple of weeks. Upon stopping medication the patients original sun sensitivity recurred in 2–30 days. Side-effects of the treatment were mostly negligible.
Zur Mukopolysaccharidausscheidung im Urin bei den sogenannten Kollagenosen
Authors: Kreysel H.W. , Köhler A.
Published: October 2009

Proteoglycans – high molecular polysaccharide-protein-complex compounds – are very important in vital intracellular and extracellular metabolic functions. Disturbances of their regulatory mechanisms are followed by an increase of their rate of biosynthesis. This obviously causes a partially irreversible damage in the connective tissue of the skin which is clinically and morphologically visible, especially in the so-called collagen diseases. Examination of the metabolism of the mucopolysaccharides of the skin is made possible by the quantitative estimation of the mucopolysaccharides in the urine. An increased elimination of the proteoglycans is discussed as well as the value of the method.
L’acrogéria est-elle une maladie du fibroblaste?
Authors: Laurent R. , Agache P.
Published: October 2009

An ultrastructural study of the dermis in a case of acrogeria is presented and compared with a healthy control of same age and sex. The overgrowing orceinophil material was mainly pseudoelastic. The collagen was hypoplastic and mostly immature. Inside and outside the fibroblasts a lot of a granulofilamentous substance intermingled with pseudoelastin and immature collagen was observed. Fibroblast cytoplasm was often distended by ergastoplasmic vacuoles filled with granulo filamentous substance and contained numerous pseudomyelinic bodies. These abnormalities suggest that acrogeria might be a fibroblast disease.
Topical Tretinoin, Vitamin A Acid (Airol®) in Acne vulgaris
Authors: Christiansen J.V. , Gadborg E. , Ludvigsen K. , Meier C.H.K. , Nørholm A. , Pedersen D. , Rasmussen K.A. , Reiter H. , Reymann F. , Sylvest B. , Unna P. , Wehnert R. , Holm P.
Published: October 2009

During the winter of 1971/72, eleven dermatologists in private practice and the dermatological departments of the Finsen Institute and Marselisborg Hospital conducted a controlled clinical trial to investigate the effect of topically applied tretinoin in patients with acne vulgaris using a 0.02-percent cream, a 0.05-percent cream, and the cream base alone. The effect of the treatment was evaluated by counting the acne lesions, the number being arranged according to a score system. As regards the effect on comedones and papules, the tretinoin cream was significantly better than the cream base alone. A concentration of 0.05% showed a quicker onset of action and a more pronounced effect than a concentration of 0.02%. The effect of the treatment was less pronounced and not statistically significant as far as pustules and cysts were concerned. The investigation confirmed previous good experience with this form of treatment. The effect upon the placebo group was considerable. This calls for caution when the effect of new acne agents is to be evaluated. Attention is drawn to the special form of cooperation used in the investigation; in this way, it was possible to include a great number of out-patients.
Der Hautvasokonstriktionstest am Menschen als Prüfmethode für Externcorticoide
Authors: Lutz Ulrike , Weirich Erich G.
Published: October 2009

The fact that many modifications of the technique originally elaborated by Mckenzie and Stoughton for skin vasoconstriction assay have been introduced considerably complicates the task of making a comparative appraisal of the methods used and the results obtained. Despite the large sources of variance, the rank orders of most topical corticoids obtained in tests carried out according to widely varying techniques by many different investigators are relatively consistent. An effort should be made to achieve a higher degree of concordance between different investigators – which applies also to the rank intervals and absolute potency values – by devising and adhering to a standardized procedure.
Nævus épidermique verruqueux inflammatoire linéaire
Authors: Tsoitis G. , Vigneron G. , Paulmier M. , Destombes P.
Published: October 2009

The inflammatory linear verrucose epidermal nevus is a recently individualized special type of linear nevus. The particular features of this nevus are represented clinically by the pruritus and the erythematous, scaly, at times psoriasiform and frequently lichenifled aspect of the papulokeratotic lesions. Histologically, this disease is characterized by a psoriasiform picture or that of chronic eczema with, in some instances, the alternation of areas of agranulosis and hypergranulosis accompanied, respectively, by overlying parakeratosis and orthokeratosis. These areas are very sharply separated. The authors report a case and discuss the clinical and histologic criteria which justify the autonomy of this nevus, as well as the differential diagnosis, the etiopathogenesis, its relation to the ‘epidermal nevus syndrome’ of Solomon et al. and its treatment.
Significance of the Local Sweat Response in the Diagnosis of Leprosy
Authors: Sehgal V.N.
Published: October 2009

Sweat response to intradermal carbachol injection was studied in hypopigmented skin lesions of 113 patients, comprising 88 with tuberculoid and 25 with dimorphous leprosy. The results were compared with contralateral controls. The sensory status of these patches prior to the test was carefully determined in each case and the patients were grouped accordingly. The sweat response was found to be significantly lowered in hypopigmented lesions. The cutaneous sensations and sweat functions were mostly corresponding. In a few cases, however, there was a demonstrable impairment of autonomic function, although the sensory functions were normal or equivocal. This method of assessment of autonomic functions, therefore, deserves a place as a diagnostic technique in leprosy.
Photoprotection of Patients Sensitive to Short and/or Long Ultraviolet Light with Dihydroxyacetone/Naphthoquinone
Authors: Fusaro Ramon M. , Johnson John A.
Published: October 2009

The topical sunscreen, dihydroxyacetone/lawsone (DHA/lawsone), was tested on 18 patients with photosensitivity disorders. Separate sequential application of the components increased sunlight tolerance in these patients twelvefold, thus providing four times greater protection against sunlight than did the previous technique employing mixtures of the components. This sunscreen, which is chemically bound to the stratum corneum, provides both long and short ultraviolet photoprotection.
Experimentelle Untersuchungen zur Differenzierung der Hautkarzinome
Authors: Schnitzer A.
Published: October 2009

The present paper examines the pathogenesis of 2 different types of skin cancer: spinal-cell carcinoma, and basal-cell carcinoma. Based on experimental evidence, the hypothesis is advanced that these 2 types of carcinoma must have different origins. Spino-cellular carcinoma develops as a result of primary damage to the epithelial cells, i.e., it is primarily cell-induced, whereas baso-cellular carcinoma appears to develop as a result of the switching-off of guidance factors within the mesenchyme, i.e., it is primarily mesenchyme-induced. Essential for a differentiated therapy of these carcinomas is the observation that the 2 types of carcinoma described herein respond in a different manner to therapeutic efforts.
Therapieresultate bei Oligospermien
Authors: Somazzi St. , Goor W. , Ott F.
Published: October 2009

The efficacy of 4 different regimens for the treatment of 55 patients with oligospermia was compared with an untreated control group of 50 patients. The following treatments were evaluated: 1. Proviron (Mesterolon) 2. Proviron-Anteron (Serumgonadotropin) 3. Rovignon (Vitamin A 30 000 I.U., Vitamin E, 70 mg) 4. Angiotri-B (HCl- of l-arginine, 250 mg. Vitamin B1, 100 mg. Vitamin B6, 100 mg. Vitamin B12, 250 mg) Statistical analysis did not show any difference between the spermatograms of the control group and any of the treated patients.
Epidermolysis Bullosa Dystrophica et Albo-Papuloidea Pasini in an Indian
Authors: Kumar Kamlesh , Kumar Raj
Published: October 2009

A young lady with epidermolysis bullosa dystrophica et albo-papuloidea Pasini t(EBDAP) is reported. The diagnosis could be made through the clinico-morphological picture of albo-papuloid efflorescences (APE), their localisation on the trunk and extremities. The involvement of the nape of the neck, retro-auricular region, and scalp is also stressed. The efflorescences appeared 2–3 weeks after her birth, and bullae started developing at the sites subject to pressure just a few days after birth. The diagnosis was determined histopathologically. Oral corticotherapy was absolutely ineffective in improving APE, though it decreased the tendency to blister.
Punctate Porokeratotic Keratoderma
Authors: Herman P.S.
Published: October 2009

Extensive review of published reports of punctate keratoderma has revealed only one similar case to that reported in the present paper. This represents a diffuse involvement of the palms and soles with pinpoint keratotic plugs and pits which were proven to be parakeratotic columns histologically identical with the cornoid lamellae of porokeratotic conditions. The clinical and histologic features which set this form of keratoderma apart from other forms of punctate keratoderma are discussed.
Tubuläre Strukturen in kranken und scheinbar gesunden Nieren bei chronischem und viszeralem Lupus erythematodes
Authors: Haustein U.-F.
Published: October 2009

In 8 patients with systemic lupus erythematosus (LE) and 23 with chronic LE, the kidneys were examined by electron microscopy after percutaneous punction. In all cases with systemic LE and LE chronicus cum exacerbatione subacuta and in two thirds of patients with localized or disseminated variants of chronic LE we found inclusions of microtubuli in the endothelial cells of glomerular, interstitial and peritubular capillaries, which partly were interpreted as (paramyxo)-virus-like particles, partly as reaction products of the cell induced by viruses. The microtubuli were observed independently of the degree of the clinical and histological manifestation of the disease of the kidney, also of the occurrence of antinuclear antibodies and of the performed pretreatment, also in clinically and histologically normal findings. The microtubuli are not specific for LE, but a diagnostic aid in chronic LE too. Its occurrence possibly explains a common pathogenesis of systemic and chronic LE, which may be differentiated by the genetically determined pattern of the reaction of the immune system and which allows transformations from one to the other variant of LE.
Contact Allergy to Bufexamac
Authors: Smeenk G.
Published: October 2009

A 44-year-old woman developed an allergic contact eczema due to bufexamac (Droxaryl cream) after the use of this cream for a circumscribed neurodermatitis of the vulva. Patch tests with 5% bufexamac in petrolatum and 1% in acetone were positive. In 20 control persons, the same agents did not cause any skin reaction. The meaning of these findings is discussed.
Lupus erythematosus profundus
Authors: Dogliotti M. , Hartdegen R. , Schmaman A.
Published: October 2009

A case of Lupus erythematosus profundus, an uncommon variant of lupus erythematosus, in a Lyoung African Bantu girl is reported. The clinical and histological pictures are described. The visible skin changes were symmetrically distributed on the face and arms, were associated with subcutaneous nodules and healed with evident scarring. This case is thought to be the first described in the African Bantu. The literature of this rare variety of discoid lupus erythematosus is briefly reviewed.
Dépigmentation due à un sparadrap
Authors: Frenk E. , Kocsis M.
Published: October 2009

A case of depigmentation caused by adhesive tape is reported. The depigmented area was devoid of dopa-positive melanocytes. Electron microscopy revealed numerous indeterminate clear cells but no melanocytes in between the basal keratinocytes; the suprabasal Langerhans’ cells were normal. The ultrastructural changes seen in this type of externally induced depigmentation were different from those in vitiligo and in one case of vitiliginous depigmentation occurring in the vicinity of a malignant melanoma, where the clear cells at the basement membrane were predominantly Langerhans’ cells with typical granules.
Elastosis Perforans Serpiginosa with Truncus Arteriosus
Authors: Caro I. , Frootko J.
Published: October 2009

A patient with elastosis perforans serpiginosa and a truncus arteriosus is presented together with a short discussion on the two conditions.
Étude du bufexamac crème et du bufexamac onguent dans le traitement de diverses dermatoses
Authors: Achten G. , Bourlond A. , Haven E. , Lapière M. , Piérard J. , Reynaers H.
Published: October 2009

The authors conducted three studies on the activity of bufexamac 5% cream or ointment in dermatoses. – A double-blind trial where results similar to those obtained with a fluocinolone acetonide 0.025% cream were recorded. – A pilot study involving mainly dermatitis. – In hypodermatitis due to circulatory disorders of varicose origin and in cheloids treated with the 5% ointment, the results were also favourable. No superinfection nor local atrophy was observed. In general, the tolerance was good.
Diabetic Scleredema
Authors: Krakowski A. , Covo J. , Berlin C.
Published: October 2009

A special form of scleredema, confined to adults with severe and complicated diabetes mellitus, has come to be recognized. It lasts for an indefinite period of time, without tendency to spontaneous remission. The name diabetic scleredema is proposed for this form. Two such patients are presented and the literature on the subject is reviewed. We believe that diabetic scleredema should be added to the list of conditions complicating or in any way associated with diabetes mellitus.
An Electron Microscopical Study of the Skin in 18 Cases of Xeroderma pigmentosum
Authors: Guerrier C.J. , Lutzner M.A. , Devico V. , Prunieras M.
Published: October 2009

The skin of 18 cases of xeroderma pigmentosum was examined electronmicroscopically. In all cases, the melanocytes were abnormal. They showed extensive melanosome polymorphism, the formation of large autophagic vacuoles; in eight cases, giant pigment granules of a unique character were present. There was passage of premelanosomes and giant pigment granules to keratinocytes. In a depigmented lesion, Langerhans’ cells were seen to be situated in the position normally occupied by melanocytes. Langerhans’ cells were also seen bearing large quantities of melanin.
The Role of Bacteria in Anhidrosis
Authors: Singh G.
Published: October 2009

The reasons for individual susceptibility to become anhidrotic on occlusion were studied. It was observed that an individual’s skin which favours the growth of resident flora on occlusion is more prone to get anhidrosis by the same process. It was also observed that sites where growth of resident organisms was suppressed by antibacterial agents did not show the same degree of anhidrosis as seen on control sites. This indicates a causal relationship between bacterial growth and anhidrosis.
Treatment of Vitiligo by Local Application of Betamethasone 17-Valerate in a Dimethyl Sulfoxide Cream Base
Authors: Koopmans-van Dorp B. , Goedhart-van Dijk B. , Neering H. , van Dijk E.
Published: October 2009

21 patients with vitiligo were treated by local application of 0.2% betamethasone 17-valerate in dimethyl sulfoxide (DMSO, 43% in a cream base) during 4 months. Symmetric patches were treated only with DMSO in the cream base. The results were very satisfactory and demonstrate that local application of betamethasone 17-valerate can induce repigmentation of vitiligo patches.
On Allergic Contact Dermatitis to Virginiamycin
Authors: Lachapelle J.M. , Lamy F.
Published: October 2009

Allergic contact dermatitis to virginiamycin is a common problem among users. In contrast, a detailed inquiry has revealed no case among employees of the virginiamycin producing factory. A maximization test with virginiamycin has been performed on 20 volunteers and its results are discussed.
Epidemieartiges Auftreten von creeping disease
Authors: Huber H.P.
Published: October 2009

Until recently creeping eruption was seen rarely in Switzerland. With the increase in tourism, in particular to East Africa, isolated cases have been seen in this country in recent years. This study describes an outbreak of epidemic proportions in a group of 24 young men after an organized group travel to Kenya. Hands and feet only were affected by characteristic lesions but the larva migrans could not be found in any of those affected, a commonly encountered difficulty. It appeared most likely that the larvae had entered the feet via sea sand and the hands during the riding of two horses shared by the group. There was no evidence of direct skin to skin transmission. There was a good therapeutic response to topical to γ-hexachlorcyclohexan 1% in an ointment base.
Zur Frage der Infektiosität der Lepra in Europa
Authors: Schuppli R.
Published: October 2009

The observations of the course of leprosy infections in Europe have shown that individual factors are responsible for the susceptibility to the disease and for its clinical form. Infections with the leprosy bacillus may occur in Europe, but rarely lead to clinical manifestations.
Carriage of Staphylococcus aureus in the Nose and on the Skin of Patients without Pyogenic Dermatoses
Authors: Uthida-Tanaka A.M.
Published: October 2009

184 strains of Staph. aureus isolated consecutively from 96 out-patients, without pyogenic dermatoses, were studied from the point of view of their resistance-sensitivity both to mercuric chloride (Moore’s test) and to four basic antibiotics, and from the point of view of phage typing. The frequency of staphylococci carriers, in the absence of pyogenic dermatoses, was high (64.6%). 40.3% of carriers yielded staphylococci from the nose and skin simultaneously; 46.8% were skin carriers exclusively and 12.9% were only nasal carriers. Extensively contaminated skin usually carried one phage type of Staph. aureus.
Kerosine Dermatitis
Authors: Tagami H. , Ogino A.
Published: October 2009

In four children, dermatitis developed following contact with kerosine-soaked clothing. Experimental reproduction of the disease was achieved in volunteer subjects by application of kerosine, supporting the view that kerosine dermatitis is of primary irritant type. Studies on the physical factors related to the skin irritability to kerosine demonstrated the following facts: (1) The skin of the Negroes appeared to be less irritable to kerosine than that of Caucasians; (2) the influence of aging is not clear, (3) no definite correlation was noted between the individual cutaneous response to kerosine and permeability of the horny layer measured by TCSA penetration time; (4) the blood circulation seems to be influencial in the skin irritability to kerosine, and the low irritability of the forehead can be explained by the richness of the dermal vasculature.
Traitement du psoriasis avec des dérivés de la podophylline
Authors: Orbaneja Gómez , Diez Iglesias , Lozano Sánchez
Published: October 2009

The results obtained with a derivate of the podophyllotoxin in a group of patients suffering of disseminated forms of psoriasis show that this therapy is undoubtedly advantageous over other medicaments of similar manner of action. This concerns the absence of changes of bone marrow and of hepatic or renal involvement.
Treatment of Localized Skin Lesions with Betamethasone 17-Valerate and Triamcinolone Acetonide in Alcoholic Solution under Occlusive Dressing
Authors: Neering H. , van der Kroon H.V.M. , Roeleveld C.G.
Published: October 2009

Betamethasone 17-valerate and triamcinolone acetonide in alcoholic solutions were applied under occlusive plastic dressing on small lesions in 16 patients with psoriasis and eczema. Besides, one patient with mycosis fungoides and one with morbus Andrews-Barber were treated. In this double blind study the betamethasone preparation gave significantly better results. Local side effects were seen with both products.
The Cutaneous Manifestations of Toxocariasis
Authors: Rook A. , Staughton R.
Published: October 2009

The case is reported of an elderly man who had never left Britain and who developed the distinctive migratory panniculitis of visceral larva migrans. Evidence is presented incriminating Toxocara canis as the probable cause. The literature on the prevalence and life cycle of T. canis in the dog and in man is examined and it is suggested that many human infections are probably undiagnosed.
Urticaire chronique et aedème de Quincke
Authors: Rives H. , Pellerat J. , Thivolet J.
Published: October 2009

The authors report their experiments with 100 cases of chronic urticaria or angioneurotic aedema. They point out especially the frequency of the allergic background (75% of the cases), the importance of the part played by Candida albicans and the results obtained by the treatment with nystatin (33%of good or very good results) or by desensitization to candidine (49% of good or very good results).It is quite certain that other infections or sensitizations can be responsible, their demonstration and the establishment of a specific treatment can similarly give good results.
Etude autoradiographique de la synthèse des acides nucléiques dans l’épithélioma calcifié de Malherbe
Authors: de la Brassinne M. , Lachapelle J.M.
Published: October 2009

The biosynthesis of nucleic acids has been evaluated in biopsy samples of pilomatrixoma using in vitro incorporation of 6-3H-thymidine (DNA) or 5-3H-uridine (RNA). The uptake of labelled thymidine is high in the outer layer of the epithelial lobes and absent in cells displaying the first histological signs of differentiation. The uptake of labelled uridineis larger and extends up to the cells displaying signs of nuclear alterations. The various connective tissues cells incorporate the two types of labelled precursors but giant cells take up only the labelled uridine.
Über die Eignung moderner Kortikoidexterna für die Behandlung von infizierten und infektionsbedrohten Dermatosen des Kindesalters
Authors: Herz G.
Published: October 2009

The usefulness of the topical corticoid Locacorten®-Vioform® is discussed by reference to the special demands which such a preparation has to meet when used to treat skin diseases in children. Since primary and secondary pyodermal infections in children constitute one of the chief groups of indications for this drug, it was deemed advisable to carry out microbiological investigations (determinations of the causative pathogens, sensitivity studies) before and after treatment; the findings obtained in these investigations are described in detail. The paper concludes with an account of the therapeutic response achieved with the various forms of Locacorten®-Vioform®.
Systematisierte Lentiginosis mit kongenitaler Taubheit und diskretem Status dysrhaphicus
Authors: Hornstein O.P. , Weidner F.
Published: October 2009

The third case of a new neuro-cutaneous syndrome, named after the first describers Capute-Rimoin-Konigsmark and consisting of patchy hyperpigmentation, congenital deafness and discrete dysraphic changes of the skeleton is reported. Despite some interferences with other known neuro-cutaneous diseases, the described combination of symptoms is so well out-lined in its phenomenological character that it justifies the interpretation as a separate syndrome.
Eccrine-Pilar Angiomatous Hamartoma
Authors: Zeller D.J. , Goldman R.L.
Published: October 2009

A skin lesion consisting of increased numbers of eccrine sweat ducts associated with enveloping angiomatous vascular channels is presented. Although a small number of similar lesions have been described, the present case is unique in that the regional pilar structures were also involved by the periadnexal vascular proliferation. The intimate topographic relationship between the epithelial and mesenchymal components suggests that the lesion arises as a consequence of abnormal adnexogenesis involving biochemical evocators of these respective components.
Two Cases of Circumscribed Calcinosis
Authors: Haim S. , Friedman-Birnbaum R.
Published: October 2009

Two cases with circumscribed calcinosis of skin are described. One is an obvious case with scleroderma, whereas the second is apparently idiopathic. However, a striking clinical similarity is seen in both. This together with other noncontributory clinical and laboratory findings observed in the second case seem suggestive that idiopathic type of calcinosis may present a preceeding or presenting symptom of a subclinical underlying disease.
Lipolysis of Skin-Surface Lipids of Acne Vulgaris Patients and Healthy Controls
Authors: Kanaar P.
Published: October 2009

Samples of skin-surface lipids of acne patients and healthy controls were analyzed for total and free fatty acids. With increasing severity of the acne, the ratio of free fatty acids to total fatty acids decreased significantly in the males (p < 0.025) and increased significantly in the females (p < 0.025). The discrepancy in these results is discussed. It is concluded, that only in the females indications for an enhanced lipolysis in the follicles of acne patients can be found.
Hyperkératose «en bouchons» d’origine mécanique
Authors: Tapernoux B. , Delacrétaz J.
Published: October 2009

Two cases of ‘plug type’ hyperkeratosis secondary to trauma are presented. Clinically as well as histologically, this disturbance of keratinisation presents certain features of Kyrle’s disease but differs from it by being localised and etiologically-related to pressure.
Über die fibrinolytische Aktivität von Epithelzellen
Authors: Haustein U.-F.
Published: October 2009

By means of the fibrin slide technique and the extraction method with potassium thiocyanate in epidermal cells of the human skin and of the bovine oesophagus a fibrinolytic activity caused by tissue activators was demonstrated. The content of tissue activators is 5 to 10 times smaller in the human epidermis than in the whole cutis (corium and epidermis).
Tumor of Follicular Infundibulum
Authors: Mehregan A.H.
Published: October 2009

A clinico-pathologic study is made of 12 cases with tumor of follicular infundibulum. This tumor appears as a slightly elevated keratotic lesion and is characterized histologically by proliferation of follicular sheath epithelium in the form of a thin subepidermal plate.
Goldallergie infolge einer primär epikutanen Sensibilisierung durch einen Goldring
Authors: Rytter M. , Schubert H.
Published: October 2009

Contact dermatitis due to gold is a rarity. We saw it on a 28-aged female patient after wearing a golden ring during one and a half year. Patch testing with the ring and sodium aurothiosulfate of very low dilutions and lymphocyte transformationtest gave a positive result. That is the evidence of the allergic character of this case.
Mitteilungen – Communications Zur Pathogenese von Hautschäden durch biologisch aktive, proteasenhaltige Waschmittel
Authors: Wüthrich B. , Schwarz K. , Eichenberger-de Beer H.E.
Published: October 2009

So-called biologically active detergents may produce direct toxic skin changes by causing the release of pharmacologically active substances (kinins). They also give rise to true contact eczema by their protease content. The significance of positive patch tests to these detergents in eczematous subjects who had not been exposed previously to enzyme containing detergents is discussed.
Multiple Skin and Gastro-intestinal Haemangiomata (Blue Rubber-Bleb Nevus)
Authors: Lichtig C. , Alroy G. , Gellei B. , Valero A.
Published: October 2009

A case of the so-called blue rubber-bleb nevus, which appeared in old age, with an anorectal bleeding is presented. Thrombocytopenia and hypercalcemia present in the case, are discussed and the pertinent literature is reviewed. The curious coincidence of 2 cystic squamous cell carcinoma in the groin is discussed, in view of the reported coincidence of other tumours. We propose to call this entity ‘multiple skin and gastro-intestinal haemangiomata’. This because the name describes the main features of this syndrome; moreover, it would call attention to the possibility of gastro-intestinal haemangiomata in such cases.
Über die Verteilung und die Aktivität von Phosphomonoesterasen in der Cutis unbefallener Psoriatikerhaut
Authors: Wohlrab W. , Peker J. , Zaumseil R.-P.
Published: October 2009

Distribution and activity of alkaline phosphatase, glucose-6-phosphatase and 5-nucleotidase have been investigated in clinically unaffected psoriatic skin, gained in the immediate neighborhood to foci. According to previous results an increased enzyme activity could be shown histochemically in histologically already alterated capillaries. Quantitative determination of enzymes however proved no difference to normal skin. These statements aid the supposition, the primary event («Primärereignis») of psoriatic reaction is not in cutaneous-vascular alterations.
L’œdème aigu hémorragique du nourrisson (purpura en cocarde avec œdème)
Authors: Laugier P. , Hunziker N. , Reiffers J. , Rudaz M.J.
Published: October 2009

Description of two cases of acute haemorrhagic oedema (purpura en cocarde with oedema) in infants with its clinical signs: oedema occurring distally, ecchymotic purpura en cocarde, associated generally with rhinopharyngeal manifestations. Histology: pericapillaritis with diapedesis and discrete inflammation is not pathognomonic.
Les otomycoses
Authors: Grigoriu D. , Font N.
Published: October 2009

Different fungi, chief among which are the genera Candida and Aspergillus, are capable of giving rise to otomycosis whose symptomatology and treatment are described. The problems of the primary or secondary nature of the otomycosis, as that of the role of non-cutaneous affections in its causation, remains open.
The Quantitative Analysis of Some Constituents of Crude Sweat
Authors: Seutter E. , Goedhart-de Groot Nel , Sutorius Annelies H.M. , Urselmann Elly J.M.
Published: October 2009

From the skin surface of patients, suffering from different skin diseases, (crude) sweat was obtained by thermal stimulation: Specific gravity, pH, Na, K, Ca, Cl, free and esterified phosphate, urea and ammonia were determined. Significant positive correlations appeared between specific gravity and Na or K, between H and K, Ca, urea or ammonia, between Na and K or Cl, between K and Ca or free phosphate, between Ca and ammonia and between urea and ammonia. Significant negative correlations appeared between H and Na or Cl, between Ca and Cl, between free phosphate and ammonia and between esterified phosphate and urea. The Ca and H concentrations, in addition to the Na, K and Cl concentrations, behaved as random samples from a normally distributed population. The Na/K ratio for subjects over 50 appeared to be raised; the Na/K and Cl/K ratios in psoriasis and atopic dermatitis were lowered and in chromium dermatitis raised.
Cutaneous Acid Mucopolysaccharides in Ascorbic Acid Deficiency
Authors: Boumans P.J. , Mier P.D.
Published: October 2009

Measurements have been made of the concentrations of hyaluronic acid and chondroitin sulphate, the rate of uptake of 35SO4 into chondroitin sulphate, and of the molecular weight of the hyaluronic acid in the skin of the guinea-pig during experimental ascorbic acid deprivation. The results indicated that the acid mucopolysaccharides do not play any significant role in this condition.