bluuebunny/crossref_metadata_2025 huggingface dataset:
ROS1 teigiamo nesmulkiųjų ląstelių plaučių vėžio gydymo entrektinibu veiksmingumas ir saugumas
Authors: Miliauskas Skaidrius
Published: October 2022

Genų pertvarkymai, paveikiantys ROS1 receptoriaus tirozino kinazę, gali sąlygoti nuolat aktyvių sulietų onkoproteinų atsiradimą. ROS1 suliejimai (angl. fusions) randami esant įvairiems navikams ir būna 1–2 proc. nesmulkiųjų ląstelių plaučių vėžio (NSLPV) atvejų. Nustačius ROS1 teigiamą NSLPV, iki 40 proc. pažengusios ligos atvejų aptinkamos centrinės nervų sistemos (CNS) metastazės. Entrektinibas yra patvirtintas tirozino kinazės inhibitorius ROS1 teigiamam NSLPV gydyti. Straipsnyje pateikiami atnaujinti integruoti klinikinių tyrimų ALKA-372-001, STARTRK-1 ir STARTRK-2 duomenys, į kuriuos įtraukti 168 sergantieji ROS1 teigiamu NSLPV ir dar negydyti pacientai. Vidutinis išgyvenamumo stebėsenos laikotarpis buvo 29,1 mėn. (interkvartilinis intervalas 21,8–35,9). Objektyvaus atsako dažnis buvo 68 proc. (95 proc. pasikliautinasis intervalas (PI) 60,2–74,8); vidutinė atsako trukmė – 20,5 mėn. Vidutinis išgyvenamumas be ligos progresavimo buvo 15,7 mėn., o vidutinis bendrasis išgyvenamumas – 47,8 mėn. 25 pacientams su išmatuojamomis CNS metastazėmis objektyvus intrakranijinio atsako dažnis buvo 80 proc. (95 proc PI: 59,3–93,2), vidutinė intrakranijinio atsako trukmė buvo 12,9 mėn., vidutinis išgyvenamumas be ligos progresavimo – 8,8 mėn. Tarp 18 pacientų, kuriems, gydant krizotinibu, liga progresavo tik CNS, toliau gydant entrektinibu, dviem atvejais pasiektas dalinis atsakas (11 proc.), o keturiais – stabili liga (22 proc.). Šios kohortos septynių pacientų subgrupėje vienam pacientui (14 proc.) buvo fiksuotas dalinis objektyvus intrakranijinis atsakas. Entrektinibas yra veiksmingas vaistas, leidžiantis prailginti išgyvenamumą, esant ROS1 teigiamam NSLPV. Pacientams, kuriems, gydant krizotinibu, liga progresavo tik CNS, vaisto veikimas buvo nepakankamai veiksmingas.
Nerezektabilios piktybinės pleuros mezoteliomos pirmaeilis gydymas nivolumabu ir ipilimumabu
Authors: Gurevičienė Giedrė
Published: October 2022

Pastaraisiais metais imuninės kontrolės taškų inhibitoriai, kurių veikimas pagrįstas priešnavikinio imuninio atsako atkūrimu, labai pakeitė įvairių lokalizacijų vėžio gydymą. Klinikinių tyrimų duomenimis, nivolumabo ir ipilimumabo derinys pagerina bendrojo išgyvenamumo rezultatus melanomos, inkstų naviko ir nesmulkių ląstelių plaučių karcinomos atveju. Šiame straipsnyje pateikiami trečiosios fazės atsitiktinių imčių klinikinio tyrimo CheckMate 743 duomenys, gauti vertinant nivolumabo ir ipilimumabo veiksmingumą ir saugumą pirmos eilės nerezektabilios piktybinės pleuros mezoteliomos (PPM) gydymui, lyginant su standartine chemoterapija platinos pagrindu ir pemetreksedu. Į klinikinį tyrimą įtraukta 713 pacientų, iš kurių 605 atitiko kriterijus ir atsitiktine tvarka paskirti į nivolumabo ir ipilimumabo grupę (n = 303) arba chemoterapijos grupę. Tarpinės analizės duomenimis, nivolumabas ir ipilimumabas statistiškai reikšmingai pagerino bendrąjį išgyvenamumą, lyginant su chemoterapijos grupe. Remiantis šiais rezultatais Jungtinių Amerikos Valstijų (JAV) Maisto ir vaistų administracija ir Europos vaistų agentūra nivolumabo ir ipilimumabo derinį patvirtino pirmaeiliam neoperabilios PPM gydymui.
Išplitusio nesmulkiųjų ląstelių plaučių vėžio, kuomet nustatyta neigiama PD-L1 raiška navikiniame audinyje, pirmaeilis gydymas pembrolizumabu kartu su chemoterapija
Authors: Matulionė Jurgita
Published: October 2022

Navikai gamina baltymą, vadinamą programuotos ląstelių žūties baltymo ligandu (PD-L1), kuris sąveikauja su organizmo imuninėmis ląstelėmis ir užkerta kelią imuniniam atsakui prieš vėžį. Imuninės kontrolės taško inhibitoriai, tokie kaip pembrolizumabas, prisijungia prie programuotos ląstelės žūties baltymo (PD-1) receptoriaus ir blokuoja jo sąveiką su ligandais PD-L1 ir PD-L2 bei aktyvina imuninį atsaką. Pembrolizumabas yra pirmasis PD-1 inhibitorius, patvirtintas išplitusio arba metastazavusio nesmulkiųjų ląstelių plaučių vėžio (NSLPV) monoterapijai, kuomet navikiniame audinyje nustatyta didelė PD-L1 raiška. Pembrolizumabą skiriant kartu su chemoterapija, kuri gali stimuliuoti priešvėžinį imuninį atsaką, jo veiksmingumas nepriklauso nuo PD-L1 raiškos navikiniame audinyje. Tyrimai parodė, kad pembrolizumabas ir chemoterapija lemia geresnį sergančiųjų su išplitusiu arba metastazavusiu NSLPV atsaką ir išgyvenamumą, lyginant su gydymu vien chemoterapija, esant neigiamai PD-L1 raiškai, ir yra pirmosios eilės gydymo standartas sergantiesiems išplitusiu arba metastazavusiu NSLPV, neatsižvelgiant į PD-L1 raišką.
Bronchų obstrukcijos išnykimas sergantiesiems astma: TRIMARAN ir TRIGGER tyrimų post hoc analizė
Authors: Vaitukaitienė Guoda
Published: October 2022

Sergantiesiems astma nuolatinė bronchų obstrukcija siejama su prastesne ligos kontrole, prastėjančia plaučių funkcija ir ligos paūmėjimais. Šiame tyrime atliekant post hoc analizę buvo vertintas ryšys tarp per atrankos vizitą registruotos tiriamųjų sumažėjusios kvėpavimo funkcijos – bronchų obstrukcijos, vertintos po dilatacijos salbutamoliu, ir bronchų obstrukcijos gydymo itin smulkių dalelių beklometazono dipropionato / formoterolio fumarato / glikopironio (BDP / FF / G) deriniu viename inhaliatoriuje arba BDP / FF deriniu 52 savaičių laikotarpiu. Taip pat buvo vertinta vidutinio sunkumo ir sunkių astmos paūmėjimų rizika. Rezultatai parodė, kad sergantiesiems astma bronchų obstrukcija susijusi su didesne paūmėjimų rizika. Gydymas triguba terapija itin smulkių dalelių BDP / FF / G deriniu buvo labiau linkęs normalizuoti plaučių funkciją ir turėjo tendenciją mažinti paūmėjimų dažnį, lyginant su gydymu BPD / FF deriniu, ypač toje pacientų grupėje, kuriems išnyko bronchų obstrukcija bent per vieną vizitą.
The Secret Children of the Border Area. Closed Institutions for Children with Disabilities in Blagoevgrad Region in the 1960-es
Authors: Popova Kristina
Published: October 2022

The article examines the activities of two closed institutions for children with disabilities in Southwestern Bulgaria in the 1960s, located in former border zones in the difficult-to-access mountain area. The living conditions, the qualifications of the staff, the work of adolescents in agriculture and the production of drawing pins, the communication barriers with parents and the outside world are presented. The documents of the two insitutions show that there were significant differences in the care of children between the single social homes for children with disabilities in Bulgaria. Located in the close conditions of spatial remoteness and the border zone, in unsuitable buildings of former border posts, the differences in the care of children in the two institutions are due to a very large extent to the different attitudes of staff and management towards children and work. But even in the best case, as it is in the home for children with severe disabilities from 3 to 10 years of age in the village of Debochitsa, the achievements of the staff were primarily reduced to improvements in the environment, care for hygiene and nutrition and educational activities with the most ‘promising’ children. In the preserved sources, children and adolescents had no names, no biographies, no faces (no photographs left), no voice. They were seen above all as bodies with physical needs, and grown adolescents as labor force. Scientific discourse in the 1950s and 1960s stressed the developmental deficits of these children and emphasized their difference' and not their abilities. This contributed to their spatial separation and isolation from other children and from the social life.
(Not)visible in Bulgarian Cinema – to the Topic of Roma and On-screen Presentations
Authors: Martonova Andronika
Published: October 2022

Film panoramas and specialized lectures related to the topic of Roma representation in the screen arts are of particular importance to the Bulgarian cultural field and society, but unfortunately they are rarely realized. The visual language’s instrumentarium could be different when try to articulate the image of the largest ethnic group in the Balkans. All autours must touch carefully the Roma filmtopics and sub-narratives in the frame area: on the one hand, they must achieve authentic representations and to demonstrate clear understanding, but on the other hand the risk of drowning in well knows stereotypes still exist. This article makes the first approach to the wide field of inisibility/ visibility of Roma in the field of Bulgarian screen arts. In our post-totalitarian cinema, the Gypsy Ethnicity affects the various types of films, their formats and genres. In the beginning (just after 1989 until the Millennium), there was a saturation and domination in documentary cinema, followed by the outflow of the subject. In that in recent years there has been an activation of the feature forms (long – and shortlength), made by new, young directors, who are trying to construct positive messages and images. An important focus is that Roma representatives (directors, screenwriters, actors etc.) are timidly included in the national cinema process. In general, however, the picture of presence is somehow marginal unfortunately.Bulgarian new cinema can fully reveal ethno-cultural differences and similarities, bring to the fore both the accordance and contrasts in the intercultural meeting. And in particular – properly and credible to paint the colorful, peculiar and distinctive world of the Roma ethnicity. Last but not least, the audiovisual arts could provoke a social change in the perception of the Other. The image of the Gypsies as a "internal foreigner", however, is gradually transformed. The research texts from the large humanity and social disciplines, and especially Film Studies, appropriatelly focusses on the diverse discussion fields in which cinema artifacts function: social anxiety, poverty, marginalization, sexualization, trauma and victimization during the Holocaust, children’s worlds and Roma childhood problems.
The issue of the deportation of Meskhetian Turks from the Georgian SSR to Kazakhstan, Uzbekistan and Kyrgyzstan in 1944
Authors: Taghizade Gunel
Published: October 2022

The article is devoted to the investigation of deportation of Meskhetian (Ahiska) Turks, a small non-titular group who has experienced multiple displacements, violent persecution, and ongoing exile since 1944. As a result of these studies, based on historical facts, the author reveals the reasons for the expulsion of Meskhetian Turks from Georgia to Central Asia in 1944, their lives as deportees and émigrés in third countries and their later rehabilitation and resettlement. The actual data as well as the versions proposed by the Soviet leadership have been studied. This study focuses on an analysis of the historiographical debates about the community of the Meskhetian Turks.
The End of the Century. Political Memories of one Non-Politician
Authors: Bozhinov Ventsislav
Published: October 2022

Evgenia Ivanova's book „The End of the Century. Political Memories of a Non-Politician“ is an autobiographical story. It not only covers the political events in Bulgaria from the 1990s, but the narrative also goes back to fundamental personae from the 19th century onwards. The book combines various genres: from classical autobiography and journalism, characterised by different nuances of historical and fictional narrative, to memoir. This is a freer view, not succumbing to the otherwise difficult-to-discern framework of the genre, which may also show the features of the romanticised autobiography. Simultaneously, the seasoned ethnological view may distinguish the peculiarities of the autobiographical tale as a methodological apparatus, as well as the realised autoreflexiveness and the growing reverse reflexiveness of the ethnologist Evgenia Ivanova towards a vast period of processes and the events it holds. Not least, the book poses the question: „Why does the author decide to tell her story up until the year 2000?“. The answer is in the book.
Reading Practices and Reading Norms: are Mobilizations Possible?
Authors: Kiossev Aleksander
Published: October 2022

The paper explores what individual readers mean by "to read enough" and "to read properly", i.e. the norm that governs reading practices. The hypothesis is that in recent decades, the normative ideas have been extremely diverse, they detached themselves to a certain extend from the reading practices and spread in different directions. This dispersal, the hypothesis states, is also associated with a reduction of the cultural imperative to read. The question is whether mobilizations are thinkable – i.e. whether it is possible to encourage the heterogeneous readers and reading communities to follow a more coherent reading norm as well as what the content of this norm could be.
Poetry of Revolt: Unmasking Revolution and Patriotism
Authors: Rogova Gaxha Blerina
Published: October 2022

This paper aims to thematize poetry as a form of protest, revolt, and rebellion. Our analysis seeks the poetry of authors who have a different cultural backgrounds, but who are approached by language and the common literary scene. Ervin Hatibi and Arben Idrizi are distinguished poets, who have bought into Albanian literature unique revolting poetry. Hatibi and Idrizi consider the poetic revolt as an essential literary act of reaction to pressure and oppression. Rebel poets both, however, neither conceive revolt as political resistance, on the contrary, revolt in their poetics arises as intra-literary rebellion which requires the revolting power of human beings, as a condition of renewal and non-alienation in a society in transition. Their point of view provides us with a geo-poetic and cultural background of the literature and culture of revolt in the works of literature of Southeast Europe. The theoretical introduction will be followed by the analysis of the authors’ poems and, in the end, we will generalize about the role that the poetic rebellion plays against the dominant political and cultural forces.
Contextualizing and historicizing the 1968 demonstrations in Kosova
Authors: Dugolli Bujar , Limani-Myrtaj Mrika
Published: October 2022

The paper explores the ideological background and political goals of the Revolutionary Movement for the Unification of Albanians, and their role in the 1968 demonstration that took place in Kosova. The paper contextualizes and historicizes the event by placing it within a spatial and chronological timeframe. By drawing from a historical narrative that describes the position of Albanians within socialist Yugoslavia, the paper traces the formation of the Revolutionary Movement for the Unification of Albanians and their ideological tenets, and posits them within a global historical Zeitgeist of the 1968 worldwide demonstrations. The paper also trails how the events of 1968 in Kosova fueled the radicalization of dissident and anti-systemic movements in Kosova that would take a central role in the historical developments of the 1970s and 1980s.
A RAPID RESEARCH - THE EFFECT OF 4 WEEKS OF ISOMETRIC PRACTICE ON FEMALE HANDBALL PLAYERS' FLEXIBILITY AND AGILITY
Authors: Vasavada Nirav
Published: October 2022

The goal of this Rapid research was to see how 4 weeks of isometric preparation affected Handball players' versatility and agility. Methods and Subjects: The research process was experimental and the sample consisted of 20 female Handball players from DPS-Bopal, Ahmedabad (14–16 years range of School children). The results indicate that isometric activities have a substantial impact on stability and agility. After four weeks of isometric testing, handball players' versatility has improved significantly. Handball players' endurance improves significantly after four weeks of isometric practises.
EFFECT OF ONLINE CLASSES ON BASIC PSYCHOLOGICAL NEEDS OF SECONDARY SCHOOL STUDENTS
Authors: Pandey Aditi
Published: October 2022

The year 2020 was marked by the Covid-19 that quick became a health crisis globally. This resulted into worldwide lockdown and closure of institutions, including schools, college and universities. In this situation of crisis schools had no choice but to adopt the online teaching-learning practice. Usually, in a classroom situation, it is easy to identify the students’ basic psychological needs as a teacher can see them all face to face and assess the situation through their facial expression and gestures but during online classes this task becomes a bit difficult. Thus in the present paper, the researcher has tried to identify whether the basic psychological needs were met during the adoption of online teaching or not and if met then to what extent students feel satisfied with their online classes. In the present paper, the theoretical framework given by Ormrod (2016) was used to assess the basic psychological needs (Arousal, Autonomy, Competence and Relatedness) of secondary students during the changed scenario of teaching-learning i.e. online classes. A descriptive survey method was used for the study. A Self-made basic psychological need scale was used as a tool to collect the data. A total of 305 students studying in class 9th and 10th standards were selected through the virtual snowball (Baltar & Brunet, 2012) sampling method. Mean, SD, Percentage and Intensity Index methods were used for the data analysis. The result revealed that most of the students fall a little above average which means that they were quite satisfied with the online classes and the basic psychological needs of all the four domains viz. arousal, autonomy, competence and relatedness, of the secondary students were met during an online classes.
Keywords: Basic Psychological needs, Secondary students, online classes, Arousal, Autonomy, Competence, and Relatedness.
Explaining Dementia Using Graph Theory and Machine Learning
Authors: Lee Jaeha
Published: October 2022

Dementia is a central nervous system neurodegenerative disease. Dementia has been discussed around different types. Among all, Alzheimer’s disease (AD) and vascular dementias (VaD) are the commonly caused disease. There is a huge research gap that graph theory has rarely been followed to explain the cognitive systems functioning particularly diseases like dementia. Thus, theoretical models of graphs can be used to interrogate the cognitive systems and the likely presence of dementia to understand the reasonings behind and thus the treatment. In this paper, three studies have been discussed in which dementia is investigated through graph theory and machine learning by using theoretical foundations to support the evidence. The first study discusses the significance of graph theory techniques and its coined ideas. There are fundamental designed parameters; connectivity, diameter vertex centrality, betweenness centrality, clustering coefficient, degree distribution, cluster analysis and graph cores. In addition to this, these are featured to analyze magneto-encephalography data to find out functional network intensity in Alzheimer’s disease affected patients. The second study explores particularly the changed structure of Alzheimer’s disease. The third study coins the significance of machine leaning philosophy that paves the way for the black box and diagnosis.
OPTIMALISASI KEUNTUNGAN PRODUKSI TANAMAN MENGGUNAKAN PROGRAM LINEAR BERDASARKAN POLA TATA TANAM
Authors: Saves Faradlillah , Soebagio Soebagio , Widodo Wahyu Tri
Published: October 2022

Abstrak: Optimalisasi Keuntungan Produksi Tanaman Menggunakan Program Linear Berdasarkan Pola Tata Tanam. Penelitian ini bertujuan untuk menetapkan pola tata tanam dan jadwal tanam yang optimal, serta memaksimalkan lahan pertanian dengan pola tanam yang lebih efektif dan efisien. Selain itu, mengetahui besarnya kebutuhan air irigasi untuk masing-masing jenis tanaman yang direncanakan dan memperoleh keuntungan yang maksimum dari hasil optimasi dengan program linear merupakan hal yang sangat penting untuk dilakukan. Penelitian ini menggunakan metode penyelesaian persamaan matematis dengan program linear menggunakan bantuan software QM for Windows 3. Penelitian dilakukan dengan 3 tahapan: Pertama, merencanakan pola tata tanam yang paling optimal di daerah irigasi Kali Bening. Kedua, menentukan efisiensi pola pemberian air pada tanaman. Ketiga, mengoptimalkan keuntungan hasil produksi pertanian menggunakan program linear dari perencanaan pola tata tanam yang efektif. Hasil penelitian dari program linear menunjukkan bahwa kebutuhan air irigasi untuk luas DI 1.141 Ha masing – masing jenis tanaman yang direncanakan dalam satu musim. Pada alternatif I dengan pola tanam padi-padi-palawija dan kebutuhan air pada tiap tanaman padi I sebesar 9,47 lt/dt/ha, padi II 2,60 lt/dt/ha, dan palawija 7,95 lt/dt/ha merupakan alternatif yang mempunyai nilai keuntungan paling maksimum dari hasil produksi pertanian yaitu sebesar Rp 107.796.111.225,- per tahun.

Abstract: Optimizing Production Profits Using Linear Programs Based on Planting Pattern. The goal of this research is to set planting pattern and optimal planting schedule, also maximize farming area with efficient and effectively planting pattern. Beside that, according to volume of water for each kind of planned crops and reach maximal profit by optimizing with linear program is important thing to do. This research using solving method of mathematic equations with linear program using assistance software of QM for Windows 3. Research does in 3 steps. Frist thing first, planning the most optimal planting pattern in irrigation area of kali bening. The second, determine the efficency of water supply pattern to plants. The third, optimize the profit of agriculture production by using linear program of effectively planting pattern. The results of research show that irrigation wateer needs for area DI 1.141 Ha to each plants which is planned for a season. In alternative I with a rice-paddy-palawija cropping pattern and the water requirement for each rice plant I is 9.47 lt/sec/ha, rice II is 2.60 lt/sec/ha, and secondary crops 7.95 lt/sec/ha. is an alternative that has the maximum profit value from agricultural production, which is Rp. 107,796,111,225, - per year.
METODE SEARCH ENGINE OPTIMIZATION SEBAGAI STRATEGI PEMASARAN DIGITAL BAGI UKM W1000K
Authors: Pandaoni Josua , Ardiansah Irfan
Published: October 2022

Abstrak: Metode Search Engine Optimization (SEO) Sebagai Strategi Pemasaaran Digital Bagi UKM Warung Sehat 1000 Kebun. UKM Warung Sehat 1000 Kebun menjual barang–barang organik mulai dari makanan, minuman, sarana berkebun, hingga bahan perawatan tubuh. Namun sebuah UKM di masa pandemi ini tentunya dituntut untuk melakukan pemasaran dan penjualan barang secara online. Maka dari itu, dalam mendukung pemasaran digital, pada bulan Januari 2021 Warung Sehat 1000 Kebun membuka toko di aplikasi tokopedia dan menjadi bagian dari tokopedia seller. Dikarenakan sangat banyak pesaing di tokopedia seller tentunya perlu dilakukan optimasi terhadap halaman produk sehingga memperoleh banyak kunjungan terhadap halaman toko. Optimasi yang dilakukan berupa optimasi toko menjadi bagian dari power merchant dan mengaktifkan fitur yang dapat menguntungkan toko, optimasi produk menggunakan metode Search Engine Optimization mulai dari nama produk, deskripsi produk, dan foto produk, hingga memaksimalkan dekorasi toko yang dapat dikreasikan melalui fitur yang tersedia di aplikasi tokopedia seller. Hasil dari penelitian ini menunjukkan bahwa optimasi yang dilakukan pada halaman toko dengan memaksimalkan fitur dan optimasi terhadap halaman produk menggunakan metode SEO merupakan strategi pemasaran yang berguna dalam meningkatkan kunjungan sehingga berpeluang besar dalam meningkatkan penjualan.

 

Abstract: Search Engine Optimization Methods As A Digital Marketing Strategy For Warung Sehat 1000 Kebun SME. Warung Sehat 1000 Kebun SME sells organic goods ranging from food, drinks, gardening tools, to body care ingredients. However, an SME during this pandemic is certainly required to do online marketing and sales of goods. Therefore, in supporting digital marketing, in January 2021 Warung Sehat 1000 Kebun opened a shop on the Tokopedia app and became part of a Tokopedia seller. Due to the fact that there are so many competitors in the shop store, it is certainly necessary to optimize the product page so that it gets a lot of visits to the shop page. Optimization is carried out in the form of store optimization being part of the merchant power and activating features that can benefit the store, product optimization using the Search Engine Optimization method starting from product names, product descriptions, and product photos, to maximizing shop decorations that can be created through features which is available on the Tokopedia Seller application. The results of this study indicate that optimization carried out on the shop page by maximizing features and optimization of product pages using the SEO method is a useful marketing strategy in increasing traffic so that it has a great opportunity to increase sales.
KAJIAN KOMPUTASI DAN EKSPERIMENTAL PENGARUH KONTROL AKTIF TERHADAP HAMBATAN AERODINAMIKA MODEL KENDARAAN
Authors: Rauf Wawan , Rifal Mohamad , Boli Rahmad Hidayat
Published: October 2022

Abstrak: Kajian Komputasi dan Eksperimental Pengaruh Kontrol Aktif terhadap HambatanAerodinamika Model Kendaraan. Dinamika aliran udara sangat dipengaruhi oleh pembentukan separasi di sekitar bodi kendaraan. Separasi aliran menjadi pemicu perbedaan tekanan yang signifikan antara sisi depan dan belakang sehingga muncul efek tarikan ke arah belakang sebagai kontributor utama besarnya hambatan aerodinamika yang diterima kendaraan. Penelitian ini fokus pada kajian hambatan aerodinamika dengan memperhatikan karakteristik pola aliran yang terbentuk dan distribusi tekanan pada dinding belakang model kendaraan melalui metode simulasi komputasi dan eksperimental laboratorium. Kontrol aktif tiupan ditempatkan pada sisi atas dinding belakang Ahmed model dan diatur pada kecepatan 1.5 m/s. Hasilnya menunjukkan bahwa penggunaan kontrol aktif tiupan pada sisi belakang mampu menunda separasi, meningkatkan koefisien tekanan, dan mengurangi hambatan aerodinamika model kendaraan.

 

Abstract: Computational and Experimental Studies of the Effect of Active Control on Aerodynamic Drag of Vehicle Models. The dynamics of air flow is strongly influenced by the formation of separations around the vehicle body. The flow separation triggers a significant pressure difference between the front and rear sides so that a rearward pull effect appears as the main contributor to the amount of aerodynamic drag received by the vehicle. This research focuses on the study of aerodynamic resistance by paying attention to the characteristics of the flow pattern formed and the pressure distribution on the rear wall of the vehicle model through computational simulation methods and laboratory experiments. The blowing active control is located on the upper side of the back wall of the Ahmed model and is set at a speed of 1.5 m/s. The results show that the use of blowing active control on the rear side is able to delay separation, increase the pressure coefficient, and reduce the aerodynamic drag of the vehicle model.
ANALISIS RISIKO PENGGUNAAN ALAT PELINDUNG DIRI PENCEGAH PENULARAN COVID-19
Authors: Ernawati Rieska , Prianjani Dana
Published: October 2022

Abstrak: Analisis Risiko Penggunaan Alat Pelindung Diri Pencegah Penularan Covid-19. Virus SARS-CoV-2 menjadi perhatian internasional karena kemudahan penyebarannya dari satu orang ke orang yang lain, dan menunjukkan bahwa individu tanpa gejala dapat menularkan virus. Virus ini memiliki laju infeksi sangat tinggi khususnya di Indonesia terutama yang terjadi pada pertengahan tahun 2021 ini. Tingginya tingkat infeksi virus corona yang menjangkiti tenaga kesehatan menuntut untuk penggunaan Alat Pelindung Diri (APD) secara lengkap saat bertugas untuk melindungi penyebaran penularan virus tersebut. APD merupakan elemen mendasar yang penting untuk membatasi penularan virus dan melindungi penggunanya. Kelengkapan APD Pencegah Covid-19 yang digunakan pada area tingkat perlindungan 3B adalah penutup kepala, masker N95, masker bedah, google, sarung tangan pertama, sarung tangan kedua, pelindung wajah, coverall, cover shoes. Penelitian ini bertujuan untuk menganalisis risiko berkaitan dengan penggunaan APD pencegah penularan COVID-19 yang digunakan oleh tenaga kesehatan di RSIGM Unissula. Analisis risiko penggunaan APD dalam penelitian ini menggunakan metode Failure Mode and Effect Analysis (FMEA) dan Fault Tree Analysis (FTA). Hasil dari metode FMEA diperoleh nilai RPN tertinggi pada APD jenis masker N95 dengan nilai sebesar 256. Penentuan top level event pada metode FTA berdasarkan risiko dari penggunaan masker N95 yang paling berbahaya yaitu terjadinya gangguan pernafasan.

 Abstract: Risk Analysis of Using Personal Protective Equipment to Prevent Covid-19 Transmission. The SARS-CoV-2 virus is of international concern because of the ease with which it can spread from person to person, and demonstrating that asymptomatic individuals can transmit the virus. This virus has a very high infection rate, especially in Indonesia, especially in the middle of 2021. The high level of corona virus infection that infects health workers demands the use of complete Personal Protective Equipment (PPE) while on duty to protect the spread of the virus transmission. PPE is a fundamental element that is important to limit the transmission of the virus and protect its users. The completeness of the Covid-19 Preventing PPE used in the 3B level of protection area is a head cover, N95 mask, surgical mask, google, first glove, second glove, face shield, coverall, shoe cover. This study aims to analyze the risks associated with the use of PPE to prevent the transmission of COVID-19 used by health workers at RSIGM Unissula. The risk analysis of the use of PPE in this study uses the Failure Mode and Effect Analysis (FMEA) and Fault Tree Analysis (FTA) methods. The results of the FMEA method obtained the highest RPN value on PPE type N95 masks with a value of 256. The determination of the top level event in the FTA method was based on the risk of using the most dangerous N95 mask, namely the occurrence of respiratory problems.
PUSAT PELATIHAN PEMUDA DAN PENDIDIKAN ANAK (SEKOLAH MINGGU) GEREJA BETHEL INDONESIA KABUPATEN GORONTALO
Authors: Wanimbo Rahel , Kaharu Arlan , Demak Nini A. Kiay
Published: October 2022

ABSTRAK

Penelitian ini bertujuan merancang dan mendesain sebagai pusat pelatihan pemuda dan pendidikan anak gereja Bethel Indonesia  Gorontalo dengan menggunakan pendekatan arsitektur psikologis. Masing-masing aliran kekristenan ini memiliki gereja tersendiri. Salah satunya yang ada di provinsi Gorontalo adalah Gereja Bethel Indonesia (GBI) yaitu suatu kelompok atau sinode gereja Kristen Protestan di Indonesia. Sebagai tempat ibadah, Gereja Bethel Indonesia (GBI) membutuhkan sarana fisik yang dapat mewadahi seluruh aktivitas ibadah jemaahnya yang memerlukan ketenangan dalam mencapai kekhusyukan ibadah dengan Allah dan dapat mewadahi kegiatan kerohanian lainnya dari segala kelompok usia termasuk para pemudanya dan anak-anak perancangan pusat pelatihan pemuda dan pendidikan anak gereja bethel dapat menjadi suatu wadah untuk kebutuhan umat kristiani yang ada di Kabupaten Gorontalo. Lokasi pusat pelatihan pemuda dan pendidikan anak gereja bethel indonesia Kabupaten gorontalo ini berada di Jl. Idris Dunggio kelurahan Kayu Merah Kecamatan Limboto dengan luasan ±4,3 ha. Tapak memiliki beberapa kelebihan potensial antara lain keberadaan tapak berdekatan dengan sarana peribadatan kristen, Taman menara keagungan Limboto, pusat pemerintahan, pusat pendidikan dan rumah warga. Penekanan pada relasi antara perilaku pengguna dan lingkungan saat berada pada bangunan akan menciptakan keindahan dalam suatu karya, terfokus pada aspek psikologi manusia dalam arsitektur yang mempengaruhi pengliatan: Bentuk ruang, Pencahayaan dan Warna.

 

Kata Kunci: Pusat pelatihan pemuda, Gereja Bethel, Indonesia
RANCANG BANGUN SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN KARYAWAN TERBAIK DENGAN METODE ANALYTICAL HIERARCHY PROCESS (AHP) PADA RUMAH MAKAN CIGANEA PUSAT
Authors: Putra Bintang Rama , Diana Anita
Published: October 2022

Abstrak: Rancang Bangun Sistem Pendukung Keputusan Pemilihan Karyawan Terbaik Dengan Metode Analytical Hierarchy Process (AHP) Pada Rumah Makan Ciganea Pusat. Pada penelitian ini membedah tentang pemilihan karyawan terbaik yang ada di Rumah Makan Ciganea Pusat yang letaknya di Purwakarta, menggunakan rancang bangun SPK dengan metode Analytical Hierarchy Process (AHP). Agar kinerja karyawan bertambah, pemilik karyawan memerlukan system pemilihan karyawan terbaik, dimana sebelumnya proses pemilihan karyawan terbaik dilakukan secara mandiri oleh pemilik. Beberapa masalah ditemukan yaitu untuk pemilihan karyawan terbaik belum terdapatnya metode yang akurat, sebelumnya juga belum ada aplikasi SPK untuk memudahkan penilaian karyawan terbaik. Metode AHP dapat memberikan nilai bobot kriteria dan prioritas alternatif dengan rasional dalam memilih karyawan terbaik berdasarkan kriteria yang sudah ditetapkan, antara lain kerajinan, tanggung jawab, kerapian kerja, dan pelayanan. Pemberian bonus bagi karyawan terbaik adalah kebijakan dari pemilik agar karyawan semakin termotivasi dalam bekerja. Aplikasi SPK berbasis web yang menggunakan metode AHP ini bertujuan untuk memberikan penilaian yang lebih objektif dan rasional setiap bulannya dan juga menghasilkan laporan berisi informasi yang efisien, yaitu laporan rangking dan laporan pemilihan karyawan terbaik.

Kata kunci: SPK; AHP; karyawan; rumah makan; aplikasi web

Abstract: Design and Build a Decision Support System for the Selection of the Best Employees Using the Analytical Hierarchy Process (AHP) Method at the Central Ciganea Restaurant. This study examines the selection of the best employees at the Central Ciganea Restaurant located in Purwakarta, using the SPK design using the Analytical Hierarchy Process (AHP) method. In order to increase employee performance, employee owners need a system for selecting the best employees, where previously the process for selecting the best employees was carried out independently by the owner. Several problems were found, namely for the selection of the best employees there was no accurate method, previously there was no SPK application to facilitate the assessment of the best employees. The AHP method can provide a rational value for weighting criteria and alternative priorities in selecting the best employees based on predetermined criteria, including work craft, responsibility, work neatness, and service. Giving bonuses to the best employees is the owner's policy so that employees are more motivated to work. This web-based DSS application that uses the AHP method aims to provide a more objective and rational assessment every month and also produces reports containing efficient information, namely ranking reports, and best employee selection reports.

Keyword: DSS; AHP; employee; restaurant; web application
Development of a Chance-Constrained Dual-Objective Fractional Programming for Shandong’s Clean Power Transition
Authors:   Environmental Systems Engineering Program, University of Regina, Regina, Saskatchewan, Canada S4S 0A2, Li M. N. , Huang G. H. ,   Environmental Systems Engineering Program, University of Regina, Regina, Saskatchewan, Canada S4S 0A2, Zhang X. Y. ,   Environmental Systems Engineering Program, University of Regina, Regina, Saskatchewan, Canada S4S 0A2, Chen J. P. ,   Environmental Systems Engineering Program, University of Regina, Regina, Saskatchewan, Canada S4S 0A2
Published: October 2022

In this study, an inexact mixed-integer interval stochastic fractional model (IMSFP) is developed for Shandong’s sustainable power system management under uncertainties. Shandong has a high proportion of fossil-fuel power, which has resulted in significant greenhouse gas emissions. Future is an essential period for energy structure transition. Developed IMSFP can effectively tackle dual objective, system efficiency represented as output/input ratios, as well as uncertainties described as interval values and probability distributions in the constraints and objectives. The results indicate that the clean power transition and capacity expansion scheme are sensitive to different constraint-violation risk levels. Obtained interval solutions can provide flexible strategies for resource allocation and expansion capacities under multiple complexities. An economic single objective model (IMCLP) is also developed, which aims at minimizing the system cost. The comparative results illustrate that the IMSFP model can better characterize the real-world power system problems through optimizing a ratio between clean energy utilization and system cost. Biomass and wind power would be major developed electricity forms in the future, and solar energy has great development potential. In short, the proposed IMSFP model is advantageous in balancing conflicting dual objectives and reflecting complicated interactions among system efficiency, economic cost, system reliability, and constraint-violation scenarios.
ACETONE, XYLENE AND AMMONIA REMOVAL ENHANCEMENT IN THE BIOFILTER PACKED WITH STEAM MODIFIED BIOCHAR
Authors: Usevičiūtė Luiza , Baltrėnaitė-Gedienė Edita , Baltrėnas Pranas , Dutta Susmita
Published: October 2022

The present study evaluated short-time effect of steam modified biochar with rhamnolipid solution on the removal of different volatile organic and inorganic compounds (acetone, xylene, ammonia) in biofilter with capillary system. Modification of pine wood biochar with steam governed better treatment of pollar acetone and ammonia compounds from the air stream with removal efficiencies of 93% and 96%, respectively. It was related to biochar’s higher average capillary radius, moisture content and lower air velocity. However, removal of xylene was much lower and reached 72% in the case of modified biochar. It can be explained by its higher Henry’s constant, hydrophobicity and non-polarity.
Panic! at the Disks: First Rest-frame Optical Observations of Galaxy Structure at z > 3 with JWST in the SMACS 0723 Field
Authors: Ferreira Leonardo , Adams Nathan , Conselice Christopher J. , Sazonova Elizaveta , Austin Duncan , Caruana Joseph , Ferrari Fabricio , Verma Aprajita , Trussler James , Broadhurst Tom , Diego Jose , Frye Brenda L. , Pascale Massimo , Wilkins Stephen M. , Windhorst Rogier A. , Zitrin Adi
Published: October 2022

We present early results regarding the morphological and structural properties of galaxies seen with the James Webb Space Telescope (JWST) at z > 3 in the Early Release Observations toward the SMACS 0723 cluster field. Using JWST we investigate, for the first time, the optical morphologies of a significant number of z > 3 galaxies with accurate photometric redshifts in this field to determine the form of galaxy structure in the relatively early universe. We use visual morphologies and Morfometryka measures to perform quantitative morphology measurements, both parametric with light profile fitting (Sérsic indices) and nonparametric (concentration, asymmetry, and smoothness (CAS) values). Using these, we measure the relative fraction of disk, spheroidal, and peculiar galaxies at 3 < z < 8. We discover the surprising result that at z > 1.5 disk galaxies dominate the overall fraction of morphologies, with a factor of ∼10 relative higher number of disk galaxies than seen by the Hubble Space Telescope at these redshifts. Our visual morphological estimates of galaxies align closely with their locations in CAS parameter space and their Sérsic indices.
The scope and scale of the life sciences (‘Nature’s envelope’)
Authors: Patterson David J.
Published: October 2022

The extension of biology with a more data-centric component offers new opportunities for discovery. To enable investigations that rely on third-party data, the infrastructure that retains data and allows their re-use should, ideally, enable transactions that relate to any and all biological processes. The assembly of such a service-oriented and enabling infrastructure is challenging. Part of the challenge is to factor in the scope and scale of biological processes. From this foundation can emerge an estimate of the number of discipline-specific centres which will gather data in their given area of interest and prepare them for a path that will lead to trusted, persistent data repositories which will make fit-for-purpose data available for re-use. A simple model is presented for the scope and scale of life sciences that includes all of the processes conducted by or caused by any and all organisms. It is depicted on a grid, the axes of which are (x) the durations of the processes and (y) the sizes of participants involved. Both axes are presented in log10 scales, and the grid is divided into decadal blocks with ten fold increments of time and size. Processes range in duration from 10-17 seconds to 3.5 billion years or more, and the sizes of participants range from 10-15 to 1.3 107 metres. Examples are given to illustrate the diversity of biological processes and their often inexact character. About half of the blocks within the grid do not contain known processes. The blocks that include biological processes amount to ‘Nature’s envelope’, a valuable rhetorical device onto which subdisciplines can be mapped, and from which can be derived some key requirements for a comprehensive data infrastructure.
Schiedea haakoaensis, a new facultatively autogamous species of ﻿Schiedea sect. ﻿Mononeura (Caryophyllaceae) from the Hawaiian Islands
Authors: Wagner Warren L. , Weller Stephen G. , Sakai Ann K. , DeMent Tom , VanDeMark Josh
Published: October 2022

In 2016 during a survey for potential fencing of the Ha‘akoa unit on windward Mauna Kea, Hawai‘i Island (Hawaiian Islands) a single plant of the genus Schiedea was discovered. No species of the genus had ever been known to occur in this area, and only three species of Schiedea were known previously from Hawai‘i Island. Two are vining species and the third is a coastal subshrub. The single plant obviously represented an interesting find, and because the plant was vegetative another visit was scheduled to collect a flowering specimen, but by then the plant had died. Soil taken from the site with seeds in the soil produced two plants, one of which flowered in cultivation in 2021. A study of this individual indicated it was a member of Schiedea sect. Mononeura, characterized by erect to ascending habit, quadrangular stems, seeds not persistent on the placenta and readily dispersing from the dehisced capsule, and flowers facultatively autogamous. With the discovery of this new species there are 35 species in this Hawaiian endemic genus.
Quand les objets linguistiques deviennent des outils de réflexion et d’enseignement universitaire : regards renouvelés sur la situation d’énonciation
Authors: Bulea Bronckart Ecaterina , Merhan Matthieu
Published: October 2022

Cet article porte sur la notion de situation d’énonciation et l’envisage tour à tour comme objet de savoir linguistique, comme objet d’enseignement et de formation, puis comme outil de réflexion et de formation en contexte universitaire. Ce regard multiple sur une notion linguistique sert à exemplifier la manière dont l’enseignement à distance provoqué par la crise sanitaire a suscité la transformation d’un objet d’enseignement en instrument, lui conférant le statut d’outil réflexif au service de la compréhension de la situation traversée, ainsi que le statut d’instrument de formation. Le va-et-vient entre situation d’énonciation comme objet de savoir, comme outil de réflexion et comme expérience en cours permet d’illustrer la dynamique des interactions entre ces différentes facettes, conduisant à une meilleure compréhension du caractère processuel des savoirs enseignés.
La performance environnementale : déterminants et impact sur la performance financière des entreprises européennes cotées
Authors: Djoutsa Wamba Léopold
Published: October 2022

L’objectif de ce papier est de mieux comprendre la politique environnementale de l’entreprise en identifiant le rôle joué par la capacité financière et la gouvernance d’entreprise sur le résultat des efforts environnementaux consentis par l’entreprise et l’impact de ces efforts sur la performance financière. En utilisant la modélisation structurelle à variables latentes par l’approche PLS (Partial Least Squares) sur les données d’un échantillon de 351 entreprises européennes cotées sur la période 2007-2015 issues d’ASSET4-ESG, il ressort des résultats d’une part que la capacité financière et la gouvernance sont des facteurs qui déterminent significativement la performance environnementale et d’autre part, que cette dernière augmente la performance financière avec un impact plus fort que la performance comptable. Par ailleurs, un impact direct de la gouvernance et de la capacité financière sur la performance financière révèle les statistiques significatives autant pour la performance comptable que pour la performance boursière.
Stéréotypes négatifs à propos des séniors chômeurs et création d’un environnement capacitant de retour vers l’emploi
Authors: Ciavaldini-Cartaut Solange , Garino Marylou
Published: October 2022

La littérature du domaine documente une intégration de stéréotypes négatifs chez les séniors chômeurs qui limite leurs capacités à retrouver un emploi. Par ailleurs, la psychologisation des politiques d’insertion et l’absence de prise en compte des facteurs organisationnels et environnementaux du marché du travail pondèrent souvent l’efficacité des dispositifs dont ils sont bénéficiaires. Cet article rend compte d’une ingénierie de projet d’insertion à caractère expérimental qui est déployée dans le Sud de la France. L’analyse de données mixtes à partir de l’approche par les capabilités et la théorie sociale cognitive de Bandura se focalise sur la substitution du caractère psychologisant de l’accompagnement vers l’emploi par celui plus développemental du projet expérimental. Ce dernier renforce les facteurs d’opportunité créés avec des entreprises partenaires et confère un caractère plus capacitant à l’environnement de retour vers l’emploi au sein du territoire concerné.
L’approche par les capabilités dans le champ du travail et de la formation : vers une définition des environnements capacitants ?
Authors: Fernagu Solveig
Published: October 2022

De nombreux travaux conduits à partir du cadre des capabilités (Sen, 2001) interrogent la qualité des environnements de travail et/ ou de formation, et leur capacité à soutenir la professionnalisation, le développement professionnel ou le pouvoir d’agir. Les capabilités se présentent comme une grille de lecture de ces processus, un outil d’évaluation de ces derniers. Plus un environnement permettra de développer ses capabilités, plus il sera considéré comme capacitant. C’est cette notion d’environnement capacitant qui sera étudiée dans ce texte,pour mieux en comprendre les enjeux, en dessiner les contours, et apprécier la manière dont elle peut permettre de penser la mise en capacité à faire et à apprendre. Nous confronterons cette notion, en voie de théorisation, à quelques recherches empiriques issues des champs de l’ergonomie constructive et des sciences de l’éducation et de la formation.
Des apprenants concepteurs de leur espace d’apprentissage
Authors: Mallet Dorothée , Falzon Pierre , Vidal-Gomel Christine
Published: October 2022

La simulation est un moyen de formation utilisé depuis plus de cinquante ans dans le domaine de la santé. Les travaux menés sur la problématisation montrent que l’élaboration même du problème est pédagogiquement intéressante. Qu’en est-il pour la formation professionnelle utilisant la simulation ? Les apprenants pourraient-ils eux-mêmes concevoir les scénarios de simulation ? Ces scénarios seraient-ils propres à leur faire acquérir les compétences visées ? Ces questions ont été appréhendées dans le cadre d’un dispositif de formation à la manutention des patients destiné aux soignants. Il utilise la simulation par jeu de rôle pour l’apprentissage du « soin de manutention raisonné » (SMR). L’approche pédagogique proposée s’érige en alternative aux formations prônant l’apprentissage des « bons gestes » puisqu’elle vise l’accompagnement à la construction d’un geste adapté et situé, source d’émancipation pour le professionnel, de bien-être et d’autonomie pour le patient Ce texte présente le contexte de cette expérimentation, l’expérimentation elle-même et ses effets, les leçons générales qu’on peut en tirer et les possibles pistes à explorer.