bluuebunny/crossref_metadata_2025 huggingface dataset:
Contextos da precarização docente na educação brasileira
Authors: Castro Neta Abília Ana de , Moura Juliana da Silva , Cardoso Berta Leni Costa , Nunes Claudio Pinto
Published: April 2020

Este artigo objetiva discutir os contextos da precarização docente na educação brasileira. Para isso, foram investigadas duas docentes que atuam na educação básica (pública e privada) em um município na região sudoeste da Bahia. As docentes participaram de uma entrevista semiestruturada contendo eixos norteadores relativos à precarização do trabalho docente. Com efeito, os depoimentos das participantes em consonância com os achados da literatura, denota a precarização do trabalho docente na educação brasileira, materializada, sobretudo, pelo modo em que o trabalho é organizado nos moldes do capitalismo contemporâneo. Esses depoimentos evidenciam que o fenômeno da precarização afeta consideravelmente o seu lócus de trabalho. Não obstante marcado pela flexibilização, intensificação, descumprimento da legislação educacional, a flexibilização das formas contratuais, a perda de autonomia sobre o processo de trabalho, a responsabilização, a competitividade, a desprofissionalização, a degradação, a educação e o labor da classe trabalhadora a serviço do capital, o sofrimento psíquico, o adoecimento e alienação dessa categoria profissional. Espera-se que esta investigação contribua tanto para o debate acadêmico como para a luta política e sindical dos trabalhadores contra a exploração capitalista e suas consequências para as condições de vida e trabalho daqueles que precisam vender sua força de trabalho para se reproduzir. Palavras-chave: Precarização. Trabalho docente. Neoliberalismo.
OPTIMISING TRAFFIC FLOW AT A SIGNALISED INTERSECTION USING SIMULATION
Authors: Malim Muhammad Rozi , Abdul Halim Faridah , Abd Rahman Sherey Sufreney
Published: April 2020

Traffic signal lights system is a signalling device located an intersection or pedestrian crossing to control the movement of traffic. The timing of traffic signal lights has attracted many researchers to study the problems involving traffic light management and looking for an inexpensive and effective solution that requires inexpensive changes in the infrastructures. A simple traffic lights system uses a pre-timed control setting based on the latest traffic data, and the setting could be manually changed. It is a common type of signal control and sometimes the setting was not correctly configured with the traffic data, thus leading to congestion at an intersection. Many mathematical strategies were applied to get an optimal setting. This study aims to model the traffic flow at Persiaran Kayangan and Persiaran Permai Intersection, Section 7, Shah Alam, as the case study, by using AnyLogic simulation software. The model was used to determine the best timings of traffic green lights that minimise the average time at the intersection and reduce traffic congestion. The findings showed that the best timings of traffic green lights for four directions at the intersection are 120 seconds, 75 seconds, 130 seconds and 100 seconds, respectively. These timings of green lights produced the lowest average time at the intersection (55.65 seconds).
DARIO ARGENTO ET LA MÈRE-SORCIÈRE : PSYCHANALYSE D’UNE IMAGE OBSÉDANTE
Authors: POP-CURȘEU Ioan
Published: April 2020

Dario Argento and the Mother-Witch: Psychoanalysis of an Obsessive Image. This paper tries to present the complexity of the maternal figures in the work and biography of film director Dario Argento. The methods of interpretation are inspired by psychoanalysis, because Argento often referred to Freud’s writings in his films or in his recent autobiography, Fear, published in 2014. The criminal mothers depicted in some films signed by Dario Argento show, through violent narratives, the difficulties he had in dealing with the maternal imago. But the most striking embodiments of the maternal monstrosity are to be found in the figure of the mother-witch, in the trilogy composed by Suspiria (1977), Inferno (1980), La Terza Madre (2007). The mother-witch has, of course, biographical sources, but its presence in some classical fairy-tales or in fin-de-siècle decadent literature also inspired the film director.
Impact of ultrasounds on physicochemical characteristics of potato tubers
Authors: SAWICKA BARBARA , PSZCZÓŁKOWSKI PIOTR , DANILČENKO HONORATA , JARIENE ELVYRA
Published: April 2020

The goal of the study was to determine the effect of sonication of different potato seed material cultivars on physicochemical properties. Tuber samples from a field experiment conducted in Parczew (51°38'N, 22°54'E) in 2015–2017 were used for the study. The experiment was carried out by the method of randomized sub-blocks, in a split-plot dependent system. The first order factor were pre-planting treatments: 1) the use of ultrasounds, 2) control object without ultrasounds. The second order factor consisted of 10 potato cultivars of all earliness groups. Seed material was a subject to immerse sonication using an ultrasonic device. Following parameters were evaluated: dry matter of tubers, starch content, textural features, acidity (pH) of potato juice. Sonication contributed to the increase in dry matter and starch contents in tubers, the change in pH towards alkaline reaction, and textural parameters of raw and cooked tubers were increased.
Examining the Impact of Legal Arizona Worker Act on Native Female Labor Supply in the United States
Authors: Gunadi Christian
Published: April 2020

Low-skilled immigration has been argued to lower the price of services that are close substitutes for household production, reducing barriers for women to enter the labor market. Therefore, policies that reduce the number of low-skilled immigrants who work predominantly in low-skilled service occupations may have an unintended consequence of lowering women’s participation in the labor market. This article examines the labor supply impact of the Legal Arizona Workers Act (LAWA), which led to a large decline in the low-skilled immigrant workforce of the state. The analysis shows no evidence that LAWA statistically significantly affected US-born women’s labor supply in Arizona. This finding is partly explained by an increase in native workers in household service occupations due to LAWA, which offset the decline in immigrants in these occupations and caused the cost of household services to be relatively uninfluenced by the passage of LAWA.
Asthma death
Authors: Faisal Hana Khairina Putri , Yunus Faisal
Published: April 2020

The prevalence of asthma is still high in many countries. However, the asthma mortality rate has been significantly decreased after the epidemic of asthma death in the 1970s. The epidemic was occurred in New Zealand and was associated with the use of high-dose inhaled fenoterol at that time. The increased use of inhaled corticosteroids (ICS) in asthma management is proposed as the key factor in the declining trend of asthma mortality rate. The risk factors of asthma-related deaths included history of near-fatal asthma requiring intubation and mechanical ventilation, hospitalisation or emergency care visit for asthma in the past year, currently using or having recently stopped using oral corticosteroids, not currently using ICS, overuse of short-acting b2-agonists, history of psychiatric disease or psychosocial problems, poor adherence with asthma medications and/or poor adherence with (or lack of) a written asthma action plan, food allergy in a patient with asthma, and air pollution.
Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism
Authors: Marushchak Mariya , Maksiv Khrystyna , Krynytska Inna , Kozak Kateryna
Published: April 2020

Background

Chronic obstructive pulmonary disease (COPD) continues to cause a heavy health and economic burden in the Europe and around the world. Arterial hypertension (AH) is considered as one of the principal COPD-associated comorbidi-ties. However, no data for association between gene polymorphism and AH in patients with COPD in Ukraine have ever been internationally published. We assessed the genotype and allele frequencies of angiotensinogen (AGT) M235T polymorphisms in patients with COPD and comorbid AH.

Methods

The study group consisted of 96 patients: Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH) and Group 3 (28 individuals with COPD and AH). The control group consisted of 20 healthy subjects. M/T genotypes of AGT were determined by polymerase chain reaction amplification.

Results

The results of the study have not demonstrated any significant impact of alleles of AGT genes on the occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated the presence of a trend towards a protective role of the M allele of the AGT gene concerning occurrence of COPD, AH and their combinations. At the same time, the presence of the T allele of the AGT gene may increase the risk for occurrence of the above-mentioned diseases.

Conclusions

The study that we have conducted suggests that the presence of T allele of the AGT gene at position 235 of the peptide chain both in homozygous and heterozygous states may increase the risk for AH in patients with COPD.
Legal Aspects of Participation Practices in the Albanian Education Context
Authors: Miço Heliona , Lumani Manjola Zaçellari
Published: April 2020

The article aims to provide an analysis of Albanian legislation regarding children’s and parents’ participation in education, by taking into account their respective roles and duties as known in the legal framework, as well as their on-going functional role as participants in practice. This research will analyse Albanian legislation and policies as regards the educational system, shedding light on the steps needed to be taken towards achieving international standards regarding the promotion of the participation of children and parents in education. Albania was under a communist regime, in which parental participation in the educational system was extremely limited and information given to parents was only regarding the progress of their child. After the fall of this monist regime changes did not happen immediately in the Albanian education system. The Convention on the Rights of the Child was one of the first international instruments ratified by the Albanian government focusing on the sanctioning and protection of the rights of the child, in a time when these rights were considered non-existent. Sanctioning the right of the child to express freely his or her own views in various issues where the child’s opinion is necessary requires that Albanian legislation includes the participation of children in every field especially in education. A general principle of the Convention is that the child’s right to be heard be considered as one of the four principles needed for the interpretation of all other articles. Research also demonstrates that effective schools have high levels of children’s and parental involvement. Despite the fact that legal steps have been taken towards recognition of the involvement of children and parents in education creating bodies such as the pupils’ government, school boards, parental councils, and lately the national council of parents, there are still unclear legal ways to implement their participation in the Albanian education system. In order to make participation possible, first and foremost, it is important to provide information regarding school activities, processes and decisions which must be transmitted to the children and parents, by creating routes of communication. This can be achieved by setting up some useful mechanisms that promote children’s and parents’ participation in education.
Microbial Consortium Promotes Growth of Zinnia and Balsam Seedlings Raised in pro trays
Authors: Sukeerthi D. , Nikhil Sai Nachu , Ashwin R. , Bagyaraj D. J.
Published: April 2020

Zinnia and Balsam are flowering plants with high economic importance in floriculture. Inoculation of the planting medium with a beneficial microbial consortium is an innovative approach to produce quality and healthy seedlings in floriculture. In the present study the influence of a microbial consortium of the arbuscular mycorrhizal fungus (AMF) Funneliformis mosseae and a plant growth promoting rhizobacterium (PGPR) Bacillus sonorensis on flowering plants Zinnia and Balsam in pro-trays under poly house conditions was investigated. Estimation of various plant growth parameters such as plant height, stem diameter, bio-volume index, vigour index, plant strength, fresh weight, dry weight and nutrient uptake was carried out to analyse the ability of the consortium to improve seedling growth. Microbial parameters such as mycorrhizal root colonization and spore count, and population of PGPR in substrate was also studied. The results suggested that inoculating the substrate in pro trays before sowing the seeds with the consortium increased plant growth significantly compared to the uninoculated plants.
Pobreza e indigencia en Argentina: construcción de una serie completa y metodológicamente homogénea
Authors: Zack Guido , Schteingart Daniel , Favata Federico
Published: April 2020

La Argentina no cuenta con una serie larga y comparable de pobreza. Esto se debe a cambios metodológicos, pero especialmente a la interrupción periódica en la publicación de determinados indicadores y en la realización de la encuesta de ingresos. Este artículo reconstruye una serie de pobreza, bajo la metodología actual del instituto de estadística, para que sea comparable con los datos que publique en el futuro. El principal aporte de este artículo es corregir la calibración de la muestra, imputar ingresos para los casos de no respuesta por el método de hot-deck y, en los casos en los que la encuesta no se realizó, estimar los datos de ingresos a través de fuentes alternativas. Los resultados muestran una fuerte caída en la pobreza entre 2003 y 2011, luego un estancamiento con ciertas oscilaciones hasta 2018, cuando se retoma un aumento hasta la actualidad.
Ligand-Controlled Regiodivergent Palladium-Catalyzed Hydrogermylation of Ynamides
Authors: Debrauwer Vincent , Turlik Aneta , Rummler Lénaïc , Prescimone Alessandro , Blanchard Nicolas , Houk Kendall N , Bizet Vincent
Published: April 2020

Ynamides are fascinating small molecules with complementary reactivities under radical, ionic and metal-catalyzed conditions. We report herein synthetic and DFT investigations of palladium-catalyzed ligand-controlled regiodivergent hydro-metallation reactions of ynamides. Germylated and stannylated enamides are obtained with excellent alpha,E- or beta,E-selectivities and a broad functional group tolerance. Such a regiodivergent palladium-catalyzed process is unique in ynamide chemistry and allows for the elaboration of metallated-enamides that are useful building blocks for cross-coupling reactions or heterocyclic chemistry. DFT calculations fully support the experimental data and demonstrate the crucial roles of the trans-geometry of the [H-Pd(L)-Ge] complex, as well as of the steric requirements of the phosphine ligand. In addition, the prevalence of a hydro-palladation pathway over a metal-palladation of the pi system of the ynamide was demonstrated.
Increasing the Functional Group Diversity in Helical β-Peptoids: Achievement of Solvent- and pH-Dependent Folding
Authors: Wellhöfer Isabelle , Beck Janina , Frydenvang Karla , Bräse Stefan , Olsen Christian Adam
Published: April 2020

We report the synthesis of a series of bis-functionalized b-peptoid oligomers of the hexamer length. This was achieved by synthesizing and incorporating protected amino- or azido-functionalized chiral building blocks into precursor oligomers by a trimer segment coupling strategy. The resulting hexamers were readily elaborated to provide target compounds displaying amino groups, carboxy groups, hydroxy groups, or triazolo-pyridines, which should enable metal ion binding. Analysis of the novel hexamers by CD spectroscopy and HSQC NMR spectroscopy revealed robust helical folding propensity in acetonitrile. CD analysis showed solvent-dependent degree of helical content in the structural ensembles when adding different ratios of protic solvents including aqueous buffer. These studies were enabled by the substantial increase in solubility compared to previously analyzed b-peptoid oligomers. This also allowed for investigation of the effect of pH on folding propensity of the amino- and carboxy-functionalized oligomers, respectively. Interestingly, we could demonstrate a reversible effect of sequentially adding acid and base, resulting in a switching between compositions of folded ensembles with varying helical content. We envision that the present discoveries can form the basis for the development of functional peptidomimetic materials responsive to external stimuli.
A Mild and Simple Method for Making MIDA Boronates
Authors: Kelly Aidan , Chen Peng-Jui (Ruby) , Klubnick Jenna , Blair Daniel J. , Burke Martin D.
Published: April 2020

Existing methods for making MIDA boronates require harsh conditions and complex procedures to achieve dehydration. Here we disclose that a pre-dried form of MIDA, MIDA anhydride, acts as both a source of the MIDA ligand and an in situ desiccant to enable a mild and simple MIDA boronate synthesis procedure. This method expands the range of sensitive boronic acids that can be converted into their MIDA boronate counterparts. Further utilizing unique properties of MIDA boronates, we have developed a MIDA Boronate Maker Kit which enables the direct preparation and purification of MIDA boronates from boronic acids using only heating and centrifuge equipment that is widely available in labs that do not specialize in organic synthesis.
Synthetic Routes to Novel Fluorogenic Pyronins and Silicon Analogs with Far-Red Spectral Properties and Enhanced Aqueous Stability
Authors: Dejouy Garance , RENAULT Kévin , Valverde Ibai E. , ROMIEU Anthony
Published: April 2020

Fluorogenic detection of reactive (bio)analytes is often achieved with "smart" probes, whose activation mechanism causes the release of aniline-based fluorophores. Indeed, the protection-deprotection of their primary amino is the simplest way to induce dramatic and valuable changes in spectral features of the fluorogenic reporter. In this context, and due to their small size and intrinsic hydrophilicity, we focused on pyronin dyes and related heteroatom analogs (i.e., formal derivatives of 3-imino-3H-xanthen-6-amine and its silicon analog) for their use as optically tunable aniline-based fluorophores. To overcome some severe limitations associated with the use of such fluorogenic scaffolds (i.e., poor aqueous stability and spectral features only in the green-yellow spectral range), the synthesis of novel unsymmetrical derivatives of (Si)-pyronins bearing a single bulky tertiary aniline (i.e., N-methylindoline and julolidine) was explored and presented in this Article. This structural alteration has been found to be beneficial to dramatically lower electrophilicity of the meso-position and to reach attractive fluorescence properties within the far-red spectral region.
Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone
Authors: Tong Bingqi , Luo Mai , Xie Yi , Spradlin Jessica , Tallarico John A. , McKenna Jeffrey M. , Schirle Markus , Maimone Thomas J. , Nomura Daniel
Published: April 2020

Targeted protein degradation (TPD) has emerged as a powerful tool in drug discovery for the perturbation of protein levels using heterobifunctional small molecules (i.e. PROTACs). E3 ligase recruiters remain central to this process yet relatively few have been identified relative to the >500 predicted human E3 ligases. While, initial recruiters have utilized non-covalent chemistry for protein binding, very recently covalent engagement to novel E3’s has proven fruitful in TPD application. Herein we demonstrate efficient proteasome-mediated degradation of BRD4 by a bifunctional small molecule linking the KEAP1-NRF2 activator bardoxolone to a BRD4 inhibitor JQ1. Notably, this work reports the first covalent, reversible E3 ligase recruiter for TPD applications.
A CONTINUOUS FLOW SULFURYL CHLORIDE BASED REACTION – SYNTHESIS OF A KEY INTERMEDIATE IN A NEW ROUTE TOWARD EMTRICITABINE AND LAMIVUDINE
Authors: de Souza Juliana , Berton Mateo , Snead David , McQuade D. Tyler
Published: April 2020

We demonstrate a continuous two-step sequence where a sulfenyl chloride is formed, trapped by vinyl acetate and chlorinated further via a Pummerer rearrangement. This sequence produces a key intermediate in our new approach to the oxathiolane core used to prepare the anti-retroviral medicines Emtricitabine and Lamivudine. During batch scale-up to tens of grams, we found that the sequence featured a strong exotherm, temperature and pressure sensitivity, and evolution of hydrogen chloride and sulfur dioxide. These reactions are ideal candidates for implementation in a continuous, mesoscale system for the sake of superior control. In addition, we found that fast reagent additions at controlled temperatures decreased byproduct formation. Herein, we discuss the flow implementation and the final reactor design that led to a 141g/h throughput system.
NMR-TS: De Novo Molecule Identification from NMR Spectra
Authors: Zhang Jinzhe , Terayama Kei , Sumita Masato , Yoshizoe Kazuki , Ito Kengo , Kikuchi Jun , Tsuda Koji
Published: April 2020

NMR spectroscopy is an effective tool for identifying molecules in a sample. Although many previously observed NMR spectra are accumulated in public databases, they cover only a tiny fraction of the chemical space, and molecule identification is typically accomplished manually based on expert knowledge. Herein, we propose NMR-TS, a machine-learning-based python library, to automatically identify any molecule from its NMR spectrum. NMR-TS discovers candidate molecules whose NMR spectra match the target spectrum by using deep learning and density functional theory (DFT)-computed spectra. As a proof-of-concept, we identify prototypical metabolites from their computed spectra. After an average 5451 DFT runs for each spectrum, six of the nine molecules are identified correctly, and proximal molecules are obtained in the other cases. This encouraging result implies that de novo molecule generation can contribute to the fully automated identification of chemical structures. NMR-TS is available at https://github.com/tsudalab/NMR-TS.
Competition between radiative and nonradiative excited state processes in photoluminescent organic molecular crystals
Authors: Rivera Miguel , Stojanovic Ljiljana , Crespo Otero Rachel
Published: April 2020

Organic molecular crystals are attractive materials for luminescent applications due to their promised tunability. However, the link between chemical structure and emissive behaviour is poorly understood due to the numerous interconnected factors which are at play in determining radiative and non-radiative behaviours at the solid state level. In this study, we investigate thirteen luminescent molecular crystals and apply newly implemented tools to study their geometric properties and constituent dimer excitonic coupling values. We then focus on the excited state decay pathways of five of the molecules. The competition between radiative and nonradiative processes was used to rationalise the different fluorescence quantum yields across systems. We found that due to the prevalence of sheet and herringbone packing in organic molecular crystals, the conformational diversity of crystal dimers is limited. Additionally, similarly spaced dimers have exciton coupling values of similar order within a 50 meV interval. Finally, we found that the accessibility of conical intersection geometries was a robust indicator of the role of nonradiative decay in the excited state mechanism of most molecules. The conical intersections all displayed a measure of rotation and puckering, where purely rotational conical intersections in vacuum lead to high energy puckered conical intersections in the crystal phase.
Molecular Docking Reveals the Potential of Aliskiren, Dipyridamole, Mopidamol, Rosuvastatin, Rolitetracycline and Metamizole to Inhibit COVID-19 Virus Main Protease
Authors: Aly Omar
Published: April 2020

Drug repurposing is a fast way to rapidly discover a drug for clinical use. In such circumstances of the spreading of the highly contagious COVID-19, searching for already known drugs is a worldwide demand. In this study, many drugs were evaluated by molecular docking. Among the test compounds, aliskiren (the best), dipyridamole, mopidamol and rosuvastatin showed higher energies of binding than that of the co-crystallized ligand N3 with COVID-19 main protease Mpro. Rolitetracycline showed the best binding with the catalytic center of the protease enzyme through binding with CYS 145 and HIS 41. Metamizole showed about 86 % of the binding energy of the ligand N3 while the protease inhibitor darunavir showed little bit lower binding energy than N3. These results are promising for using these drugs in the treatment and management of the spreading of COVID-19 virus. Also, it could stimulate clinical trials for the use of these drugs by systemic or inhalation route.The results stimulate the evaluation of these drugs as anti COVID-19 especially aliskiren which showed the highest score of binding with the binding site of N3. This will be added to its renin inhibition and advantage of renin inhibition and possibility of the reduced expression of ACE2[12]. Dipyridamole and mopidamol showed a potential to be more Mpro inhibitor than ligand N3 and darunavir. Also, dipyridamole has the property of antiviral activity beside its use to decrease the hypercoagulabilty that happens due to COVID infection in addition to the property of promoting type I interferon (IFN) responses and protect mice from viral pneumonia [30]. Rolitetracycling is an amazing in its binding mode in the active site of the protease pocket it seemed as it is tailored to be buried in that pocket. Mopidamol and rosuvastatin are slightly better than the co-crystallized ligand N3 and darunavir in binding mode which nominate the as COVID-19 protease inhibitors. Hopefully this study will help in the repurposing a drug for the treatment of COVID-19.
Thermoelasticity in Organic Semiconductors Determined with Terahertz Spectroscopy and Quantum Quasi-Harmonic Simulations
Authors: Banks Peter A. , Maul Jefferson , Mancini Mark T. , Whalley Adam C. , Erba Alessandro , Ruggiero Michael
Published: April 2020

The thermomechanical response of organic semiconducting solids is an essential aspect to consider in the design of materials for advanced applications, and in particular, flexible electronics. The non-covalent intermolecular forces that exist in organic solids not only result in a diverse set of mechanical properties, but also a critical dependence of those same properties on temperature. However, studying the thermoelastic response of solids is experimentally challenging, often requiring large single-crystals and sensitive experimental apparatus. An alternative contactless approach involves using low-frequency vibrational spectroscopy to characterize the underlying intermolecular forces, and then combining this information with solid-state density functional theory simulations to retrieve the mechanical response of materials. This methodology leverages recent advances in the quasi-harmonic approximation to predict the temperature evolution of crystalline structures, dynamics, and associated forces, and then utilizes this information to determine the elastic tensor as a function of temperature. Here, this methodology is illustrated for two prototypical organic semiconducting crystals, rubrene and BTBT, and suggests a new alternative means to characterizing the thermoelastic response of organic materials.
Two-Phase Synthesis of Taxol®
Authors: Kanda Yuzuru , Nakamura Hugh , Umemiya Shigenobu , Puthukanoori Ravi Kumar , Appala Venkata Ramana Murthy , Gaddamanugu Gopi Krishna , Paraselli Bheema Rao , Baran Phil
Published: April 2020

Taxol® is widely regarded as amongst the most famed natural isolates ever discovered, and has been the subject of innumerable studies in both basic and applied science. Its documented success as an anticancer agent, coupled with early concerns over supply, stimulated a furious worldwide effort from chemists to provide a solution for its preparation through total synthesis. Those pioneering studies proved the feasibility of retrosynthetically-guided access to synthetic Taxol, albeit in minute quantities and with enormous effort. In practice, all medicinal chemistry efforts and eventual commercialization have relied upon natural- (plant material) or biosynthetically-derived (synthetic biology) supplies. Here we show how a complementary divergent synthetic approach that is holistically patterned off of biosynthetic machinery for terpene synthesis can be used to arrive at Taxol®.
Molecular Packaging of Biocatalysts Using a Robust Protein Cage
Authors: Lončar Nikola , Rozeboom Henriette J. , Franken Linda E. , C. A. Stuart Marc , Fraaije Marco
Published: April 2020

In this paper, we report on the discovery of a novel, robust protein cage (encapsulin) that we could use for packaging various biocatalysts. We have elucidated the structure of the stable encapsulin by electron microscopy and X-ray diffraction. Furthermore, we developed an effective expression system for the encapsulin and a facile protocol for preparing encapsulated enzymes. By packaging and testing various enzymes (varying in size, oligomeric structure, and cofactor type) we demonstrate that, through encapsulation, the enzymes become significantly more stable. We also provide evidence that the pores of the encapsulin, through a size-exclusion effect, can modulate the substrate acceptance profile of an encapsulated enzyme.
IDEOLOGI DALAM NOVEL NEGERI 5 MENARA KARYA A.	FUADI: TINJAUAN IDEOLOGI ALTHUSSER
Authors: Nilofar Naila
Published: April 2020

Tulisan ini bertujuan untuk menganalisis novel “Negeri 5 Menara” karya A. Fuadi dengan menggunakan pendekatan Ideologi Althusser. Metode yang digunakan dalam penelitian ini adalah desktiptif kualitatif. Hasil penelitian menunjukkan bahwa ideologi yang terdapat dalam novel “Negeri 5 Menara” adalah ideologi kapitalis dan ideologi agama. Ideologi kapitalis terlihat dalam masyarakat bahwa orang yang belajar dalam lembaga formal karena ingin mendapatkan pekerjaan setelah lulus sekolah. Ideologi lain yang terlihat dalam novel “Negeri 5 Menara” adalah ideologi agama, yaitu pesantren sebagai lembaga formal mengajarkan kepada para santrinya untuk menuntut ilmu hanya karena Allah semata.
TRANSFORMASI TATA RUANG DALEM DI SEKITAR KAWASAN JERON BETENG, YOGYAKARTA
Authors: Arvisista ; Y. Basuki Dwisusanto Arvisista
Published: April 2020

Abstrak- Dalem atau rumah bangsawan adalah rumah yang diberikan oleh Keraton Yogyakarta kepada saudara atau kerabat Sultan. Dalem berada di dalam dan sekitar kawasan Jeron Beteng, Yogyakarta. Saat ini dalem sudah mengalami banyak perubahan terutama dari tata ruang dalem. Perubahan tersebut dipengaruhi dari peningkatan kepadatan penduduk dan perubahan pola pikir masyarakat menjadi lebih modern di lingkungan kawasan Jeron Beteng. Perubahan-perubahan yang muncul pada dalem terutama dalam aspek tata ruanganya menjadi hal yang menarik untuk diteliti. Tujuan penelitian ini adalah untuk memahami perubahan yang terjadi pada tata ruang dalem dan aspek yang mendominasi terjadinya perubahan pada dalem.Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif dengan mengkaji dari aspek sejarah kawasan dan budaya masyarakat Jawa. Kedua aspek tersebut menjelaskan adanya adat atau ritual yang dilakukan secara terus menerus dan menjadi dasar pembentukkan tata ruang dengan ruang-ruang yang dibutuhkan pada rumah masayarakat Jawa. Data diperoleh dengan melakukan observasi ke lapangan dan wawancara serta studi literatur. Analisis dalem dikaji dengan mempelajari budaya dan sejarah Yogyakarta serta prinsip arsitektur Yogyakarta.Penelitian ini mencoba mengungkap bagaimana perubahan yang terjadi terhadap tata ruang dalem dengan membandingkan kondisi tata ruang berdasarkan prinsip arsitektur Yogyakarta dengan kondisi dalem saat ini. Aspek tata ruang yang dibahas adalah orientasi, fungsi, bentuk bangunan, zonasi ruang, dan susunan massa dalem. Hasil dari penelitian ini didapatkan bahwa perubahan yang terjadi pada dalem diawali dari peningkatan kepadatan penduduk dan pola pikir modern sehingga terjadinya perubahan fungsi pada dalem untuk pemanfaatan ruang, perubahan bentuk bangunan, perubahan zonasi ruang pada kawasan, dan penambahan massa pada susunan massa.
UM OLHAR SOBRE OS PRECEDENTES NO SISTEMA JURÍDICO BRASILEIRO
Authors: Almeida Letícia Da Silva , Perpétuo Braga Carlos Henrique
Published: April 2020

Trabalhou-se o tema dos precedentes, permitindo compreender sua importância e superar resistências dos operadores do mundo jurídico. Essa visão tende a ser ultrapassada, porque o cidadão, no Estado Democrático de Direito, não pode se submeter às interpretações individualmente dadas por magistrados, que se apoiam na sua independência para formar o convencimento, ao arrepio de entendimentos consolidados que servem também para pautar o agir da própria população. O CPC/2015 encampou a ideia de observarem os precedentes, vinculando a sua observância, pela segurança jurídica e integridade das decisões. Utilizou-se pesquisa bibliográfica, por meio do método dedutivo e, marco teórico Carnelutti e Chiovenda.
ANÁLISE DO DANO MORAL COLETIVO AMBIENTAL NO CASO DE ROMPIMENTO DE BARRAGENS
Authors: Seabra Filter Pedro Agão , Girardello Faccio Lucas
Published: April 2020

O presente trabalho propõe estudar o Dano Moral Coletivo Ambiental. Para tanto, analisa-se o dano moral como reflexo dos efeitos causados pelo dano ao meio ambiente, e a possibilidade, que se demonstra cabível, de ser utilizado para recompor os sofrimentos causados à coletividade. Utiliza-se, portanto, conceituações doutrinária e legal, investigando a aplicação jurisprudencial da temática. Ainda, apresenta-se o caso do rompimento da barragem de Fundão, Desastre de Mariana. Por consequência, se observará seus reflexos jurídicos até então, para que assim se possa produzir um quadro geral da aplicação do instituto ora pesquisado, na tentativa de formular um padrão de aplicabilidade.
APONTAMENTOS SOBRE OS PRINCÍPIOS DE JUSTIÇA EM JOHN RAWLS A PARTIR DE UMA TEORIA DA JUSTIÇA
Authors: Lazzaretti Segat Juliana , Junior Valmôr Scott
Published: April 2020

A obra Uma teoria de justiça, de John Rawls, representou, no século XX, um divisor de águas na filosofia política e moral. O artigo objetiva abordá-la de maneira resumida, lançando luz à ideia dos dois princípios de justiça que, segundo o autor, seriam escolhidos em uma posição inicial de igualdade. Inicialmente, é feita uma breve abordagem sobre a posição original. Após, aborda-se o objeto dos dois princípios de justiça (a estrutura básica da sociedade), para, posteriormente, fazer uma incursão sobre esses princípios. Em termos metodológicos, trata-se de pesquisa de cunho qualitativo, por meio de revisão bibliográfica.
ANÁLISE DOS DIREITOS AUTORAIS NO ENSINO A DISTÂNCIA
Authors: Gabrich Frederico Andrade , Mourão Marina Veloso
Published: April 2020

A modalidade de ensino a distância é a que mais cresce no Brasil e está a cada dia mais presente na vida da população, ávida pela informação, por tecnologia, pelo acesso ao conhecimento e pelos custos baixos na educação. Nesse contexto, o presente estudo propõe analisar, com fundamento no método dedutivo, a tutela autoral do material didático criado e produzido para os cursos lecionados na modalidade de ensino a distância, considerando as recentes transformações sociais, os novos desafios para a educação e tendo como marco teórico a Lei nº 9.610/98, que regula os direitos autorais no Brasil (LDA).
BRUMADINHO, A ATIVIDADE EMPRESARIAL E ECONÔMICA E O PAPEL DO ESTADO.
Authors: De Almeida Almeida Valério Catarin de
Published: April 2020

O rompimento da barragem da Companhia Vale do Rio Doce em Brumadinho, grandes prejuízos e faz pensar sobre o papel do Estado e a atividade empresarial, diante da livre iniciativa, lucros, e a função social da empresa, assim como sua atuação na prevenção de outros desastres, como também sua postura pós-acidente, assim o objetivo desse estudo reside em apreciar um panorama social e econômico da cidade de Brumadinho inserindo nesse cenário a atuação e a figura do Estado, como regulador da inciativa privada e promotor do bem estar social.
A FUNDAMENTAÇÃO KANTIANA DA DOUTRINA DA INCORPORAÇÃO DO BILL OF RIGHTS
Authors: Figueira Márcio Alves , Mendes Rodrigo Vicente Maia
Published: April 2020

RESUMOO artigo científico visa esclarecer a fundamentação kantiana da doutrina da incorporação do Bill of Rights. A Suprema Corte dos Estados Unidos estendeu o Bill of Rights aos Estados. Neste trabalho pretendemos demonstrar a fundamentação kantiana na doutrina da incorporação do Bill of Rights, abordando a corrente filosófica do utilitarismo e do contratualismo. Em primeiro lugar, examinaremos o precedente da Suprema Corte dos Estados Unidos Gideon v. Wainwright (1963) e em seguida analisaremos filosoficamente o precedente. Em relação aos procedimentos metodológicos esta pesquisa caracteriza-se como qualitativa e descritiva, uma revisão de literaturas por meio de livros, revistas especializadas e periódicos.Palavras-Chave: Bill of Rights; Doutrina da Incorporação; Utilitarismo; Contratualismo; Imperativo categórico kantiano. ABSTRACTThe scientific article aims to clarify the Kantian foundation of the doctrine of incorporation of the Bill of Rights. The United States Supreme Court has extended the Bill of Rights to the states. In this paper we intend to demonstrate the Kantian grounding in the doctrine of incorporation of the Bill of Rights, addressing the philosophical current of utilitarianism and contractualism. First, we will examine the precedent of the United States Supreme Court Gideon v. Wainwright and then we will philosophically analyze the precedent. Regarding the methodological procedures this research is characterized as qualitative and descriptive, literature review through books.Keywords: Bill of rights; Doctrine of Incorporation; Utilitarianism; Contractualism; Kantian categorical imperative.
Dai a César o que é de César e a Deus o que é de Deus
Authors: Bobrzyk Sandro André
Published: April 2020

O presente artigo tem o propósito de analisar o instituto da imunidade tributária concedida aos templos de qualquer culto, sob a égide da Constituição da República Federativa do Brasil de 1988. A impossibilidade de tributar está prevista no artigo 150, VI, alínea “b”, do referido diploma. O artigo mostrará que o tema em comento, constantemente judicializado, comporta uma série de discussões, tanto doutrinárias como jurisprudenciais. De toda sorte, é preciso clarear quais são os critérios objetivos e reduzir as subjetividades ao analisar a aplicabilidade deste dispositivo e as novas configurações de culto e de religião.
A GARANTIA DE ACESSO À JUSTIÇA NA EVOLUÇÃO DOS DIREITOS SOCIAIS NAS CONSTITUIÇÕES BRASILEIRAS E SUA RESTRIÇÃO NO CENÁRIO LEGISLATIVO ATUAL
Authors: Resende Bárbara Fabiane , Júnior Silvério Pereira
Published: April 2020

A presente pesquisa tem o intuito de apresentar os aspectos históricos da conquista dos direitos sociais através de um panorama da evolução desses direitos nas Constituições Brasileiras além de analisar a efetividade do direito de acesso à justiça no ordenamento jurídico vigente, precipuamente como as restrições sofridas no direito de gratuidade judiciária e do jus postulandi contribuíram para que o acesso à justiça sofresse demasiadas limitações, contrariando o que se encontra previsto na Constituição Federal Brasileira de 1988. Para isso, o método de pesquisa utilizado é o qualitativo, através da análise de documentos e pesquisa bibliográfica e legislativa.
Two European Conflicts Conventions
Authors: Juenger Friedrich K
Published: April 2020

The states of the European Union have so far concluded two major conflict of laws conventions:  The Brussels Convention on Jurisdiction and the Enforcement of Judgments in Civil and Commercial Matters, and the Rome Convention on the Law Applicable to Contractual Obligations.  Professor Juenger here reflects on the creation and experience of these treaties and concludes that the Brussels/Lugano Conventions present a model for the world while the Rome Convention shows what to avoid.
Only strict quarantine measures can curb the coronavirus disease (COVID-19) outbreak in Italy, 2020
Authors: Sjödin Henrik , Wilder-Smith Annelies , Osman Sarah , Farooq Zia , Rocklöv Joacim
Published: April 2020

Several Italian towns are under lockdown to contain the COVID-19 outbreak. The level of transmission reduction required for physical distancing interventions to mitigate the epidemic is a crucial question. We show that very high adherence to community quarantine (total stay-home policy) and a small household size is necessary for curbing the outbreak in a locked-down town. The larger the household size and amount of time in the public, the longer the lockdown period needed.
Understanding coronavirus disease (COVID-19) risk perceptions among the public to enhance risk communication efforts: a practical approach for outbreaks, Finland, February 2020
Authors: Lohiniva Anna-Leena , Sane Jussi , Sibenberg Katja , Puumalainen Taneli , Salminen Mika
Published: April 2020

Understanding risk perceptions of the public is critical for risk communication. In February 2020, the Finnish Institute for Health and Welfare started collecting weekly qualitative data on coronavirus disease (COVID-19) risk perception that informs risk communication efforts. The process is based on thematic analysis of emails and social media messages from the public and identifies factors linked to appraisal of risk magnitude, which are developed into risk communication recommendations together with health and communication experts.
INTERACTIVE TECHNOLOGIES IN TEACHING MATHEMATICS IN PRIMARY SCHOOL: FROM PLANNING TO RESULTS
Authors: Rudenko N.
Published: April 2020

The article states the author's definition of the concept interactive technologies at mathematics lessons. They are defined as the set and the certain sequence of pedagogical methods that are aimed at the realization of a didactic objective, the activation of the participants’ subject-subject interaction in the educational process, which affects the quality of mathematics preparation and enhances pupil’ thinking skills. The structure of interactive mathematics lesson at primary school is determined: motivation activity; announcement, presentation of the topic and learning outcomes; providing the necessary information; interactive activity; reflection; evaluating the results of the lesson. Interactive technologies are selected and classified according to their didactic aim and function and are appropriate for use at mathematics lessons of the New Ukrainian School.
THE PEDAGOGICAL CASE AS A MEANS OF THE DEVELOPMENT OF CRITICAL THINKING OF FUTURE TEACHERS
Authors: Leontieva I.
Published: April 2020

Training of a highly qualified specialist, able to professionally apply in practice modern pedagogical forms, methods and techniques based on the formed competences and abilities, as well as his own readiness to solve actual problems of pedagogical science and educational practice, should be due to such methods and technologies that will ensure the educational process higher education, including active, or as they are called interactive, teaching methods. Their essence lies in the organization of interaction-based learning, dialogue, during which students learn to think critically, group into groups to share experiences and solve complex practical problems based on the analysis of circumstances and information provided, take into account alternative points of view, take responsibility , make thoughtful decisions, refocus knowledge-retransmitters on tutors, facilitators, supervisors, coaches, and passive students to active participants in the educational process. These include case-study (translated from English - the method of situation analysis). The training case is a description of the real situation; events that have taken place in a particular field and are described by the author in order to provoke discussion in a teaching audience, stimulate students to thorough analysis, productive discussion and decision making. The case should be considered as the only information complex that allows the student to fully understand the situation. The essence and historical dimension of case-study technology are covered in the article; the possibilities of its introduction into the educational process of preparation of masters in the specialty "011 Educational, pedagogical sciences" are outlined; the works of domestic and foreign scientists, teacher-practitioners on the use of educational cases in the practice of teacher training are analyzed; an example of a pedagogical case and an algorithm of work with him by a teacher and students during a practical lesson are offered.
The Improvement of Cognitive Function and Decrease the Level of Stress in the Elderly with Brain Gym
Authors: Azizah Lilik Marifatul , Martiana Tri , Soedirham Oedojo
Published: April 2020

The decline in cognitive function in the elderly, which is part of the aging process can result in long-term memory problems and information processes, so it is often regarded as a stressor that causes stress and perceived as an adverse threat. Brain gym can improve memory, decreased emotional stress and the clearer mind. The aim of the study analyzed the effectiveness of brain gym in improving cognitive function and decreased the level of stress of elderly. Pre-experimental study of one group pretest-posttest design with 35 samples selected by simple random sampling. The frequency of Brain Gym exercise twice a week with duration of every 15 minutes and done in four weeks. Measurement of stress level using DASS, while Cognitive function with MMSE. Data analyzed using Wilcoxon signed rank test. The results showed improvement of cognitive function in elderly and decreased stress level after brain gym (p = 0.001 and p = 0.009 at Î± = 0.05). Brain gyms are more effective at lowering stress levels than older cognitive function improvements that require longer and more intense time to improve concentration and elderly memory.

 

Keywords: Brain Gym, Kognitif, Stress, Elderly
Psychological distress on childhood cancer: a concept analysis
Authors: Arifah Siti , Pongthavornkamol Kanaungnit
Published: April 2020

This concept analysis is to clarify the psychological distress in term of pediatric cancer care.  The literature review conducted to defining the antecedents, attributes and consequences of psychological distress analysed by Walker and Avent's theory.  The finding were different components of antecedents and attributes, while the consequences was only negative.