bluuebunny/crossref_metadata_2025 huggingface dataset:
Anatomic Sites and Associated Clinical Factors for Deep Dyspareunia
Authors: Yong Paul J. , Williams Christina , Yosef Ali , Wong Fontayne , Bedaiwy Mohamed A. , Lisonkova Sarka , Allaire Catherine
Published: August 2017

Introduction

Deep dyspareunia negatively affects women’s sexual function. There is a known association between deep dyspareunia and endometriosis of the cul-de-sac or uterosacral ligaments in reproductive-age women; however, other factors are less clear in this population.

Aim

To identify anatomic sites and associated clinical factors for deep dyspareunia in reproductive-age women at a referral center.

Methods

This study involved the analysis of cross-sectional baseline data from a prospective database of 548 women (87% consent rate) recruited from December 2013 through April 2015 at a tertiary referral center for endometriosis and/or pelvic pain. Exclusion criteria included menopausal status, age at least 50 years, previous hysterectomy or oophorectomy, and not sexually active. We performed a standardized endovaginal ultrasound-assisted pelvic examination to palpate anatomic structures for tenderness and reproduce deep dyspareunia. Multivariable regression was used to determine which tender anatomic structures were independently associated with deep dyspareunia severity and to identify clinical factors independently associated with each tender anatomic site.

Main Outcome Measure

Severity of deep dyspareunia on a numeric pain rating scale of 0 to 10.

Results

Severity of deep dyspareunia (scale = 0–10) was independently associated with tenderness of the bladder (b = 0.88, P = .018), pelvic floor (levator ani) (b = 0.66, P = .038), cervix and uterus (b = 0.88, P = .008), and cul-de-sac or uterosacral ligaments (b = 1.39, P < .001), but not with the adnexa (b = −0.16, P = 0.87). The number of tender anatomic sites was significantly correlated with more severe deep dyspareunia (Spearman r = 0.34, P < .001). For associated clinical factors, greater depression symptom severity was specifically associated with tenderness of the bladder (b = 1.05, P = .008) and pelvic floor (b = 1.07, P < .001). A history of miscarriage was specifically associated with tenderness of the cervix and uterus (b = 2.24, P = .001). Endometriosis was specifically associated with tenderness of the cul-de-sac or uterosacral ligaments (b = 3.54, P < .001).

Conclusions

In reproductive-age women at a tertiary referral center, deep dyspareunia was independently associated not only with tenderness of the cul-de-sac and uterosacral ligaments but also with tenderness of the bladder, pelvic floor, and cervix and uterus.

Yong PJ, Williams C, Yosef A, et al. Anatomic Sites and Associated Clinical Factors for Deep Dyspareunia. Sex Med 2017;5:e184–e195.
Adolescent escitalopram prevents the effects of maternal separation on depression‐ and anxiety‐like behaviours and regulates the levels of inflammatory cytokines in adult male mice
Authors: Wang Qi , Dong Xiaomei , Wang Yan , Liu Mengxi , Sun Anji , Li Nannan , lin Yiwei , Geng Zhongli , Jin Ye , Li Xiaobai
Published: August 2017

There is little research on the effects of adolescent administration of antidepressants on behavioural function and inflammation in early‐life stressed adult mice. Using maternal separation (MS), a paradigm of early adversity, we investigated the effects of adolescent (PND 33‐54) escitalopram (ES; 10 mg/kg) exposure on depression‐ and anxiety‐like behaviours and the levels of inflammatory cytokines (interleukin [IL]‐1β, tumor necrosis factor [TNF]‐α, and IL‐10) in the ventral hippocampus (HPV), prefrontal cortex (PFC), and serum in adult (PND 61) male offspring mice. The results showed that MS has no effect on locomotor activity, but increased depression‐like behaviours in the saccharin preference test and increased anxiety‐like behaviours in the social preference and elevated plus maze tests. MS increased the levels of IL‐1β in the HPV, PFC, and serum, while decreasing the level of IL‐10 in the HPV. Furthermore, adolescent ES treatment inhibited these depression‐ and anxiety‐like behaviours, decreased the levels of IL‐1β, and increased the level of IL‐10 in the HPV. The results also showed that there are no effects of chronic escitalopram administration on normal behaviour in control mice. Taken together, the current data provide experimental evidence that MS increases depression and anxiety levels in adult male offspring. Additionally, the findings support the idea that early pharmacological intervention with ES may be an effective treatment for reducing the behavioral abnormalities induced by early adversity and regulating the underlying inflammatory mechanisms involved.
FEMINIST SCIENCE AND CHACOAN ARCHAEOLOGY: REPLY TO WARE
Authors: Heitman Carrie C.
Published: August 2017

Ware's comment misses the point of Heitman's (2016) article and further demonstrates the need for feminist science perspectives.
On the Division of Moral Labour for Human Rights Between States and Corporations: A Reply to Hsieh
Authors: ARNOLD Denis G.
Published: August 2017

In a series of previous articles I have defended the claim that there are robust, theoretical justifications for concluding that corporations have human rights obligations and that those obligations are distinct from the larger set of human rights obligations that are properly attributed to states. Hsieh claims that corporations do not have human rights obligations. In this reply it is argued that even if one takes what Hsieh refers to as an ‘institutional approach’ to understanding the human rights obligations of states, corporations are nonetheless properly understood to have human rights obligations regarding those with whom they interact, such as workers, customers and community members.
Should the Injustice Done to Her be the Law’s Concern? The Case of Cinderella
Authors: Acorn Annalise
Published: August 2017

In this paper I draw on the fairy tale Cinderella to examine the distinction articulated in analytical jurisprudence between harm and injustice. I argue that the wrong done to Cinderella is an injustice, not a harm. While law is increasingly concerned with harms to children, it is persistently unconcerned with the injustices they suffer. This, I argue, is a mistake informed by a deeply gendered understanding of the distinction between the public and private realms. From Cinderella’s case, I turn to the US Supreme Court decision in Brown v. Board of Education and the settlement of the residential schools claims of Indigenous children in Canada to argue that the law ought not to take the view that injustice to children is not legally cognizable unless and until it can be conceptually transposed into harm. Injustice to children ought particularly to engage the law’s concern where (as in both school segregation in the US and the residential schools in Canada) state action is directly responsible for the injustice in question.
Quantifying Network Dynamics and Information Flow Across Chinese Social Media During the African Ebola Outbreak
Authors: Feng Shihui , Hossain Liaquat , Crawford John W. , Bossomaier Terry
Published: August 2017

Objective

Social media provides us with a new platform on which to explore how the public responds to disasters and, of particular importance, how they respond to the emergence of infectious diseases such as Ebola. Provided it is appropriately informed, social media offers a potentially powerful means of supporting both early detection and effective containment of communicable diseases, which is essential for improving disaster medicine and public health preparedness.

Methods

The 2014 West African Ebola outbreak is a particularly relevant contemporary case study on account of the large number of annual arrivals from Africa, including Chinese employees engaged in projects in Africa. Weibo (Weibo Corp, Beijing, China) is China’s most popular social media platform, with more than 2 billion users and over 300 million daily posts, and offers great opportunity to monitor early detection and promotion of public health awareness.

Results

We present a proof-of-concept study of a subset of Weibo posts during the outbreak demonstrating potential and identifying priorities for improving the efficacy and accuracy of information dissemination. We quantify the evolution of the social network topology within Weibo relating to the efficacy of information sharing.

Conclusions

We show how relatively few nodes in the network can have a dominant influence over both the quality and quantity of the information shared. These findings make an important contribution to disaster medicine and public health preparedness from theoretical and methodological perspectives for dealing with epidemics. (Disaster Med Public Health Preparedness. 2018;12:26–37)
A unique winged euthycarcinoid from the Permian of Antarctica
Authors: Collette Joseph H. , Isbell John L. , Miller Molly F.
Published: August 2017

Euthycarcinoid arthropods (Cambrian–Triassic) were likely the first animals to transition from oceanic to freshwater and emergent environments. Although their basic bauplan is well known, they have a poor fossil record because their non-sclerotized exoskeleton was rarely preserved. Euthycarcinoids’ unusual morphology (varying numbers of body segments, seemingly dichotomous possession of either mandibles or a labrum, specialized or generalized limbs, and possession by some euthycarcinoid species of sternal pores—structures possibly analogous to coxal vesicles in myriapods) contribute to uncertainty regarding their relationship to other arthropod groups; while their poor fossil record masks the evolutionary transitions within and between the separate realms they inhabited (marine, freshwater, emergent). A new euthycarcinoid from a Permian polar proglacial lake is described herein that is morphologically unlike all other euthycarcinoids, and interpreted as being well adapted for a nekton-benthic lifestyle. Antarcticarcinus pagoda n. gen. n. sp. possesses a pair of large wing-like processes that project laterally from the preabdominal dorsal exoskeleton. A trace fossil from the overlying Mackellar Formation, cf. Orbiculichnus, which was previously interpreted as having been produced by insects taking off or landing on wet sediments, is reinterpreted herein as being produced by A. pagoda n. gen. n. sp. due to the high degree of morphological similarity between traces and body fossils. This occurrence indicates that euthycarcinoids were able to adapt to life in temperate freshwater environments, while possible subaerial adaptations hint at an ability to breathe air. Indeed, if euthycarcinoids could breathe air, Cambrian terrestrial forays and rapid transition (by the Ordovician) into freshwater environments might be explained.
Bouldery slope landforms on Mt. Biseul, Korea, and implications for paleoclimate and slope evolution
Authors: Rhee Hyun-Hee , Seong Yeong-Bae , Jeon Young-Gweon , Yu Byung-Yong
Published: August 2017

Identification of bouldery landforms in mountains and correctly understanding their formative processes play an important role in reconstructing the geomorphic history of a region. We propose that blocks were liberated by frost cracking and wedging of cliff walls during the last glacial period. However, we further suggest and test four hypotheses comprising different scenarios for preconditioning by chemical weathering and subsequent block transport using terrain analysis, characterization of boulders, and10Be exposure dating. Frost shattering from the backing cliff produced the boulders since the beginning of the last glacial period (~80 ka), and gelifluction transported them downslope throughout the last glacial period. Their activity then entered a dormant phase at the beginning of the Holocene. Distribution patterns of exposure ages of tors and block streams are similar to those of previous studies, implying that bouldery landscapes in the southern Korean Peninsula were likely to be formed by similar processes under periglacial conditions. The timing of active periods in transport of block streams corresponds well with the cold periods identified in regional and global climate proxy records. Interestingly, the activity of block streams in the study area reached a maximum during Marine Oxygen Isotope Stage 3 to 2 when the growth rate of nearby speleothems was lowest.
Social Protection for the Informal Sector in Urban China: Institutional Constraints and Self-selection Behaviour
Authors: JIANG JIN , QIAN JIWEI , WEN ZHUOYI
Published: August 2017

The Chinese government has recently expanded the scope of urban social insurance programmes. However, social protection for the labour force of the urban informal sector, which reaches about half the number of urban workers, lags significantly behind. This under-coverage may be due to institutional constraints, particularly the household registration system hukou, and self-selection behaviour related to the limited benefits of social insurance. Drawing on a recent nationwide individual-level survey and city-level statistics, this study examines these two explanations for the under-enrolment on the social insurance programme. First, results suggest that hukou and the intergovernmental fiscal system are major institutional constraints. Second, self-selection behaviour in programme enrolment is verified. Employers in the informal sector are likely to opt out of social insurance. More importantly, employers in the informal sector, with rural or non-local hukou, are likely to opt out of social insurance, which suggests that self-selection behaviour is constrained by institutions. Such findings have important implications for broad theoretical and policy debates on universal social protection.
Stability results for local zeta functions of groups algebras, and modules
Authors: ROSSMANN TOBIAS
Published: August 2017

Various types of local zeta functions studied in asymptotic group theory admit two natural operations: (1) change the prime and (2) perform local base extensions. Often, the effects of both of the preceding operations can be expressed simultaneously in terms of a single formula, a statement made precise using what we call local maps of Denef type. We show that assuming the existence of such formulae, the behaviour of local zeta functions under variation of the prime in a set of density 1 in fact completely determines these functions for almost all primes and, moreover, it also determines their behaviour under local base extensions. We discuss applications to topological zeta functions, functional equations, and questions of uniformity.
Utility of Ambulance Data for Real-Time Syndromic Surveillance: A Pilot in the West Midlands Region, United Kingdom
Authors: Todkill Dan , Loveridge Paul , Elliot Alex J. , Morbey Roger A. , Edeghere Obaghe , Rayment-Bishop Tracy , Rayment-Bishop Chris , Thornes John E. , Smith Gillian
Published: August 2017

Introduction

The Public Health England (PHE; United Kingdom) Real-Time Syndromic Surveillance Team (ReSST) currently operates four national syndromic surveillance systems, including an emergency department system. A system based on ambulance data might provide an additional measure of the “severe” end of the clinical disease spectrum. This report describes the findings and lessons learned from the development and preliminary assessment of a pilot syndromic surveillance system using ambulance data from the West Midlands (WM) region in England.

Hypothesis/Problem

Is an Ambulance Data Syndromic Surveillance System (ADSSS) feasible and of utility in enhancing the existing suite of PHE syndromic surveillance systems?

Methods

An ADSSS was designed, implemented, and a pilot conducted from September 1, 2015 through March 1, 2016. Surveillance cases were defined as calls to the West Midlands Ambulance Service (WMAS) regarding patients who were assigned any of 11 specified chief presenting complaints (CPCs) during the pilot period. The WMAS collected anonymized data on cases and transferred the dataset daily to ReSST, which contained anonymized information on patients’ demographics, partial postcode of patients’ location, and CPC. The 11 CPCs covered a broad range of syndromes. The dataset was analyzed descriptively each week to determine trends and key epidemiological characteristics of patients, and an automated statistical algorithm was employed daily to detect higher than expected number of calls. A preliminary assessment was undertaken to assess the feasibility, utility (including quality of key indicators), and timeliness of the system for syndromic surveillance purposes. Lessons learned and challenges were identified and recorded during the design and implementation of the system.

Results

The pilot ADSSS collected 207,331 records of individual ambulance calls (daily mean=1,133; range=923-1,350). The ADSSS was found to be timely in detecting seasonal changes in patterns of respiratory infections and increases in case numbers during seasonal events.

Conclusions

Further validation is necessary; however, the findings from the assessment of the pilot ADSSS suggest that selected, but not all, ambulance indicators appear to have some utility for syndromic surveillance purposes in England. There are certain challenges that need to be addressed when designing and implementing similar systems.

TodkillD,LoveridgeP,ElliotAJ,MorbeyRA,EdeghereO,Rayment-BishopT,Rayment-BishopC,ThornesJE,SmithG.Utility of ambulance data for real-time syndromic surveillance: a pilot in the West Midlands region, United Kingdom.Prehosp Disaster Med.2017;32(6):667–672.
Everyday Resistance to Workfare: Welfare Beneficiary Advocacy in Auckland, New Zealand
Authors: Baker Tom , Davis Courtney
Published: August 2017

Beneficiary advocacy organisations, which provide advice to individual claimants about how best to navigate the welfare system, exist in the context of complex and opaque benefit-claiming processes that have resulted from workfare policies. Drawing on a case study of Auckland Action Against Poverty, an organisation specialising in poverty activism and services for welfare beneficiaries, this article examines the provision of beneficiary advocacy services as a form of everyday resistance to workfare policies. Everyday resistance is less overtly political, less confrontational, and more ordinary than spectacular acts of resistance such as protests, but one that should not be seen as accommodating workfare policies and the market-based reform projects to which they are connected. By supporting individuals to defiantly persevere with their benefit claims, beneficiary advocates help to actively resist the operational logic of dissuasion that defines contemporary workfare.
INFINITARY PROPOSITIONAL RELEVANT LANGUAGES WITH ABSURDITY
Authors: BADIA GUILLERMO
Published: August 2017

Analogues of Scott’s isomorphism theorem, Karp’s theorem as well as results on lack of compactness and strong completeness are established for infinitary propositional relevant logics. An “interpolation theorem” (of a particular sort introduced by Barwise and van Benthem) for the infinitary quantificational boolean logicL∞ωholds. This yields a preservation result characterizing the expressive power of infinitary relevant languages with absurdity using the model-theoretic relation of relevant directed bisimulation as well as a Beth definability property.
“Neoliberalism is Fascism and Should Be Criminalized”: Bulgarian Populism as Left-Wing Radicalism
Authors: Ganev Venelin I.
Published: August 2017

The main argument presented in this essay is that the politics of Ataka, the most successful and influential populist party in Bulgaria, should be construed as a form of left-wing radicalism. Originally a nationalist formation, over the last decade Ataka has evolved into a broader social movement that blames free markets, neoliberalism, and US led neocolonialism for the country's misfortunes. Today its activists routinely assault liberal democracy as a political system unable to cope with the evils of capitalism, and seek to marginalize political actors and social constituencies identified as pro-western.
Exclusionary Egalitarianism and the New Cold War
Authors: Porter-Szűcs Brian
Published: August 2017

It seems clear that there is a common ideological foundation linking Putin, Le Pen, Orbán, Erdoğan, Trump, Kaczyński, and others, but labeling that ideology has been difficult. Many in the media have called them “populists,” but this term can be misleading and imprecise. This essay focuses on Poland in order to propose a genealogy that transcends conventional divisions between left and right. The phrase “exclusionary egalitarianism” helps us recognize the intertwined commitments to both racism and nationalism on the one hand, and an opposition to inequalities of wealth and status on the other. While the analogy to the radical right of the 1930s is helpful, there is an even closer link to the “national communists” of the 1960s and 1970s.
How Much Trait Variance Is Captured by Measures of Academic State	Emotions?
Authors: Nett Ulrike E. , Bieg Madeleine , Keller Melanie M.
Published: August 2017

Abstract. Although the popularity of research on academic emotions is on the rise, little is known about the extent to which these emotional experiences are due to stable (trait) versus situational (state) influences. In the present paper, we applied the latent state-trait approach (LST) to multiple state assessments of five frequently experienced discrete academic emotions (enjoyment, pride, anger, anxiety, boredom) to disentangle their trait versus state variance components. We had two main aims: (1) to identify the differential contributions of the person-specific (trait) and situation-specific (state) variance components of discrete academic emotions, and (2) to examine the relations between different discrete academic emotions with regard to their latent trait and latent state residual components. Eight hundred thirty-seven German students participated in this diary study that lasted 2–3 weeks. During this time, students responded to short (two items per emotion) questionnaires asking about their lesson-specific state emotions in mathematics. The results revealed that for each academic emotion the trait variance and state residual components were of about equal size. Further, while differently valenced (positive vs. negative) latent trait components of students’ emotions were mostly uncorrelated (with the exception of boredom), differently valenced latent state residual components of students’ emotions were negatively correlated. We discuss our findings in relation to the structure of current affect and highlight their implications for classroom practices.
Gradient light interference microscopy for 3D imaging of unlabeled specimens
Authors: Nguyen Tan H. , Kandel Mikhail E. , Rubessa Marcello , Wheeler Matthew B. , Popescu Gabriel
Published: August 2017

Multiple scattering limits the contrast in optical imaging of thick specimens. Here, we present gradient light interference microscopy (GLIM) to extract three-dimensional information from both thin and thick unlabeled specimens. GLIM exploits a special case of low-coherence interferometry to extract phase information from the specimen, which in turn can be used to measure cell mass, volume, surface area, and their evolutions in time. Because it combines multiple intensity images that correspond to controlled phase shifts between two interfering waves, gradient light interference microscopy is capable of suppressing the incoherent background due to multiple scattering. GLIM can potentially become a valuable tool for in vitro fertilization, where contrast agents and fluorophores may impact the viability of the embryo. Since GLIM is implemented as an add-on module to an existing inverted microscope, we anticipate that it will be adopted rapidly by the biological community.
Inorganic carbon distribution and CO2 fluxes in a large European estuary (Tagus, Portugal)
Authors: Oliveira A. P. , Cabeçadas G. , Mateus M. D.
Published: August 2017

Ten field cruises were carried out in Tagus estuary from 1999 to 2007 to study the dynamics of the inorganic carbon system. Dissolved inorganic carbon (DIC) and total alkalinity (TA) increased with salinity. DIC and TA were generally conservative in the estuarine mixing zone (salinity > 10), while a complex distribution pattern was observed at the upper estuary. DIC values peaked 1786.9 ± 155.8 µmol kg−1 at that segment. Estimated annual mean fluxes of DIC were 0.27 Tg C yr−1 from the river to the estuary, and 0.37 Tg C yr−1 from here to the coastal area. The Tagus estuary was always CO2 supersaturated, with partial pressure of CO2 (pCO2) reaching 9160 µatm in the upper estuary. An average emission of 0.11 Tg C yr−1 was estimated from the estuary to the atmosphere, corresponding to 23% of exported DIC. Only 8% of the riverine DIC was ventilated. The non-conservative behaviour of CO2 parameters in the estuary segment under freshwater influence was attributed to alternations in the relevance of riverine/terrestrial runoff, photosynthesis, aerobic respiration, organic matter mineralization and CaCO3 precipitation/dissolution.
Shannon entropy of brain functional complex networks under the influence of the psychedelic Ayahuasca
Authors: Viol A. , Palhano-Fontes Fernanda , Onias Heloisa , de Araujo Draulio B. , Viswanathan G. M.
Published: August 2017

The entropic brain hypothesis holds that the key facts concerning psychedelics are partially explained in terms of increased entropy of the brain’s functional connectivity. Ayahuasca is a psychedelic beverage of Amazonian indigenous origin with legal status in Brazil in religious and scientific settings. In this context, we use tools and concepts from the theory of complex networks to analyze resting state fMRI data of the brains of human subjects under two distinct conditions: (i) under ordinary waking state and (ii) in an altered state of consciousness induced by ingestion of Ayahuasca. We report an increase in the Shannon entropy of the degree distribution of the networks subsequent to Ayahuasca ingestion. We also find increased local and decreased global network integration. Our results are broadly consistent with the entropic brain hypothesis. Finally, we discuss our findings in the context of descriptions of “mind-expansion” frequently seen in self-reports of users of psychedelic drugs.
Three-terminal resistive switch based on metal/metal oxide redox reactions
Authors: Huang Mantao , Tan Aik Jun , Mann Maxwell , Bauer Uwe , Ouedraogo Raoul , Beach Geoffrey S. D.
Published: August 2017

A solid-state three-terminal resistive switch based on gate-voltage-tunable reversible oxidation of a thin-film metallic channel is demonstrated. The switch is composed of a cobalt wire placed under a GdOx layer and a Au top electrode. The lateral resistance of the wire changes with the transition between cobalt and cobalt oxide controlled by a voltage applied to the top electrode. The kinetics of the oxidation and reduction process are examined through time- and temperature-dependent transport measurements. It is shown that that reversible voltage induced lateral resistance switching with a ratio of 103 can be achieved at room temperature. The reversible non-volatile redox reaction between metal and metal oxide may provide additional degrees of freedom for post-fabrication control of properties of solid-state materials. This type of three-terminal device has potential applications in neuromorphic computing and multilevel data storage, as well as applications that require controlling a relatively large current.
Groundwater rejuvenation in parts of India influenced by water-policy change implementation
Authors: Bhanja Soumendra N. , Mukherjee Abhijit , Rodell Matthew , Wada Yoshihide , Chattopadhyay Siddhartha , Velicogna Isabella , Pangaluru Kishore , Famiglietti James S.
Published: August 2017

The dwindling groundwater resource of India, supporting almost one fifth of the global population and also the largest groundwater user, has been of great concern in recent years. However, in contrary to the well documented Indian groundwater depletion due to rapid and unmanaged groundwater withdrawal, here for the first time, we report regional-scale groundwater storage (GWS) replenishment through long-term (1996–2014, using more than 19000 observation locations) in situ and decadal (2003–2014) satellite-based groundwater storage measurements in western and southern parts of India. In parts of western and southern India, in situ GWS (GWSobs) has been decreasing at the rate of −5.81 ± 0.38 km3/year (in 1996–2001) and −0.92 ± 0.12 km3/year (in 1996–2002), and reversed to replenish at the rate of 2.04 ± 0.20 km3/year (in 2002–2014) and 0.76 ± 0.08 km3/year (in 2003–2014), respectively. Here, using statistical analyses and simulation results of groundwater management policy change effect on groundwater storage in western and southern India, we show that paradigm shift in Indian groundwater withdrawal and management policies for sustainable water utilization appear to have started replenishing the aquifers in western and southern parts of India.
Experimental study on the location of an acoustic emission source considering refraction in different media
Authors: Zhou Zi-long , Zhou Jing , Dong Long-jun , Cai Xin , Rui Yi-chao , Ke Chang-tao
Published: August 2017

The existing acoustic emission (AE) source location methods assume that acoustic waves propagate along straight lines, and the source location is determined by average wave velocity. Because of the heterogeneity of materials, location results often fail to meet the accuracy requirement. For this reason, an AE source location method considering refraction in different media was proposed in this paper. According to sensor coordinates, the arrival time of acoustic waves, the velocities of acoustic waves in two kinds of media, the space-time relation equations of the AE source point and the measuring point were established by the precise coordinates of the AE source based on Snell’s law. The feasibility of the algorithm was verified by experiments, and the factors influencing location accuracy were also analysed. The results show that the algorithm proposed in this paper is applicable for both the same medium and different media, and the accuracy of localization is not affected by the ratio of wave velocities in two media or the distance from the AE source to the refraction surface.
Machine learning applications for prediction of relapse in childhood acute lymphoblastic leukemia
Authors: Pan Liyan , Liu Guangjian , Lin Fangqin , Zhong Shuling , Xia Huimin , Sun Xin , Liang Huiying
Published: August 2017

The prediction of relapse in childhood acute lymphoblastic leukemia (ALL) is a critical factor for successful treatment and follow-up planning. Our goal was to construct an ALL relapse prediction model based on machine learning algorithms. Monte Carlo cross-validation nested by 10-fold cross-validation was used to rank clinical variables on the randomly split training sets of 336 newly diagnosed ALL children, and a forward feature selection algorithm was employed to find the shortest list of most discriminatory variables. To enable an unbiased estimation of the prediction model to new patients, besides the split test sets of 150 patients, we introduced another independent data set of 84 patients to evaluate the model. The Random Forest model with 14 features achieved a cross-validation accuracy of 0.827 ± 0.031 on one set and an accuracy of 0.798 on the other, with the area under the curve of 0.902 ± 0.027 and 0.904, respectively. The model performed well across different risk-level groups, with the best accuracy of 0.829 in the standard-risk group. To our knowledge, this is the first study to use machine learning models to predict childhood ALL relapse based on medical data from Electronic Medical Record, which will further facilitate stratification treatments.
Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the canadian biomarker integration network in depression
Authors: Farzan Faranak , Atluri Sravya , Frehlich Matthew , Dhami Prabhjot , Kleffner Killian , Price Rae , Lam Raymond W. , Frey Benicio N. , Milev Roumen , Ravindran Arun , McAndrews Mary Pat , Wong Willy , Blumberger Daniel , Daskalakis Zafiris J. , Vila-Rodriguez Fidel , Alonso Esther , Brenner Colleen A. , Liotti Mario , Dharsee Moyez , Arnott Stephen R. , Evans Kenneth R. , Rotzinger Susan , Kennedy Sidney H.
Published: August 2017

Subsequent to global initiatives in mapping the human brain and investigations of neurobiological markers for brain disorders, the number of multi-site studies involving the collection and sharing of large volumes of brain data, including electroencephalography (EEG), has been increasing. Among the complexities of conducting multi-site studies and increasing the shelf life of biological data beyond the original study are timely standardization and documentation of relevant study parameters. We present the insights gained and guidelines established within the EEG working group of the Canadian Biomarker Integration Network in Depression (CAN-BIND). CAN-BIND is a multi-site, multi-investigator, and multi-project network supported by the Ontario Brain Institute with access to Brain-CODE, an informatics platform that hosts a multitude of biological data across a growing list of brain pathologies. We describe our approaches and insights on documenting and standardizing parameters across the study design, data collection, monitoring, analysis, integration, knowledge-translation, and data archiving phases of CAN-BIND projects. We introduce a custom-built EEG toolbox to track data preprocessing with open-access for the scientific community. We also evaluate the impact of variation in equipment setup on the accuracy of acquired data. Collectively, this work is intended to inspire establishing comprehensive and standardized guidelines for multi-site studies.
Carriage frequency, phenotypic, and genotypic characteristics of methicillin-resistant Staphylococcus aureus isolated from dental health-care personnel, patients, and environment
Authors: Khairalla Ahmed S. , Wasfi Reham , Ashour Hossam M.
Published: August 2017

There is limited data on methicillin-resistant Staphylococcus aureus (MRSA) carriage in dental clinics. 1300 specimens from patients, health personnel, and environmental surfaces of a dental clinic in Egypt were tested for MRSA. Antibiotic susceptibility, biofilm formation, Staphylococcal protein A (spa) typing, SCCmec typing, and PCR-based assays were used to detect mecA, mecC, vanA, Panton-Valentine Leukocidin toxin (PVL), and toxic shock syndrome toxin-1 (tst) genes. Among 34 mecA-positive MRSA isolates, five (14.7%) were PVL-positive, seventeen (50%) were tst-positive, ten (29.4%) were vanA-positive, while none harboured mecC. MRSA hand carriage rates in patients, nurses, and dentists were 9.8%, 6.6%, and 5%. The respective nasal colonization rates were 11.1%, 6.7%, and 9.7%. 1.3% of the environmental isolates were MRSA-positive. Strong and moderate biofilm-forming isolates represented 23.5% and 29.4% of MRSA isolates. 24 MRSA isolates (70.6%) were multi-resistant and 18 (52.9%) harboured SCCmec IV. Among eight spa types, t223 (26.5%), t267 (23.5%), and t14339 (23.5%) were predominant. We noted an alarming genetic relatedness between 7 (20.6%) MRSA isolates and the epidemic EMRSA-15 clone, as well as a combined occurrence of tst and PVL in 3 (8.8%) isolates. Results suggest high MRSA pathogenicity in dental wards highlighting the need for more efficient surveillance/infection control strategies.
Neuromorphic photonic networks using silicon photonic weight banks
Authors: Tait Alexander N. , de Lima Thomas Ferreira , Zhou Ellen , Wu Allie X. , Nahmias Mitchell A. , Shastri Bhavin J. , Prucnal Paul R.
Published: August 2017

Photonic systems for high-performance information processing have attracted renewed interest. Neuromorphic silicon photonics has the potential to integrate processing functions that vastly exceed the capabilities of electronics. We report first observations of a recurrent silicon photonic neural network, in which connections are configured by microring weight banks. A mathematical isomorphism between the silicon photonic circuit and a continuous neural network model is demonstrated through dynamical bifurcation analysis. Exploiting this isomorphism, a simulated 24-node silicon photonic neural network is programmed using “neural compiler” to solve a differential system emulation task. A 294-fold acceleration against a conventional benchmark is predicted. We also propose and derive power consumption analysis for modulator-class neurons that, as opposed to laser-class neurons, are compatible with silicon photonic platforms. At increased scale, Neuromorphic silicon photonics could access new regimes of ultrafast information processing for radio, control, and scientific computing.
Bronchoalveolar Lavage Fluid Protein Expression in Acute Respiratory Distress Syndrome Provides Insights into Pathways Activated in Subjects with Different Outcomes
Authors: Bhargava Maneesh , Viken Kevin , Wang Qi , Jagtap Pratik , Bitterman Peter , Ingbar David , Wendt Chris
Published: August 2017

Acute respiratory distress syndrome (ARDS) is associated with high mortality. We sought to identify biological pathways in ARDS that differentiate survivors from non-survivors. We studied bronchoalveolar lavage fluid (BALF) from 36 patients with ARDS (20 survivors, 16 non-survivors). Each sample, obtained within seven days of ARDS onset, was depleted of high abundance proteins and labeled for iTRAQ LC-MS/MS separately. Protein identification and relative quantification was performed employing a target-decoy strategy. A variance weighted t-test was used to identify differential expression. Ingenuity Pathway Analysis was used to determine the canonical pathways that differentiated survivors from non-survivors. We identified 1115 high confidence proteins in the BALF out of which 142 were differentially expressed between survivors and non-survivors. These proteins mapped to multiple pathways distinguishing survivors from non-survivors, including several implicated in lung injury and repair such as coagulation/thrombosis, acute phase response signaling and complement activation. We also identified proteins assigned to fibrosis and ones involved in detoxification of lipid peroxide-mediated oxidative stress to be different in survivors and non-survivors. These results support our previous findings demonstrating early differences in the BALF protein expression in ARDS survivors vs. non-survivors, including proteins that counter oxidative stress and canonical pathways associated with fibrosis.
Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation
Authors: Albert Brice J. , Niu Austin , Ramani Rashmi , Marshall Garland R. , Wender Paul A. , Williams Robert M. , Ratner Lee , Barnes Alexander B. , Kyei George B.
Published: August 2017

Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus. Elimination of these reservoirs through the administration of synergistic combinations of latency reversing agents (LRAs), such as histone deacetylase (HDAC) inhibitors and protein kinase C (PKC) modulators, provides a promising strategy to reduce if not eradicate the viral reservoir. Here, we demonstrate that largazole and its analogues are isoform-targeted histone deacetylase inhibitors and potent LRAs. Significantly, these isoform-targeted HDAC inhibitors synergize with PKC modulators, namely bryostatin-1 analogues (bryologs). Implementation of this unprecedented LRA combination induces HIV-1 reactivation to unparalleled levels and avoids global T-cell activation within resting CD4+ T-cells.
Bio-implant as a novel restoration for tooth loss
Authors: Lee Dong-Joon , Lee Jong-Min , Kim Eun-Jung , Takata Takashi , Abiko Yoshihiro , Okano Teruo , Green David W. , Shimono Masaki , Jung Han-Sung
Published: August 2017

A dental implant is used to replace a missing tooth. Fixing the implant in its natural position requires the engineering of a substantial amount of conformal bone growth inside the implant socket, osseointegration. However, this conventional implant attachment does not include the periodontal ligament (PDL), which has a fundamental role in cushioning high mechanical loads. As a result, tooth implants have a shorter lifetime than the natural tooth and have a high chance of infections. We have engineered a “bio-implant” that provides a living PDL connection for titanium implants. The bio-implant consists of a hydroxyapatite coated titanium screw, ensheathed in cell sheets made from immortalized human periodontal cells. Bio-implants were transplanted into the upper first molar region of a tooth-extraction mouse model. Within 8 weeks the bio-implant generated fibrous connective tissue, a localised blood vessel network and new bone growth fused into the alveolar bone socket. The study presents a bio-implant engineered with human cells, specialised for the root connection, and resulted in the partial reconstruction of a naturalised tooth attachment complex (periodontium), consisting of all the principal tissue types, cementum, PDL and alveolar bone.
Knockdown of Tlr4 in the Arcuate Nucleus Improves Obesity Related Metabolic Disorders
Authors: Zhao Yongli , Li Guohua , Li Ying , Wang Yuchuan , Liu Zhengjuan
Published: August 2017

High-fat diet-induced hypothalamic metabolic inflammation is emerging as a cause for the development of obesity. It is acknowledged that Toll-like receptor4 (TLR4) signaling plays a crucial role in triggering of the hypothalamic metabolic inflammation during the course of diet-induced obesity. Whether hypothalamic arcuate nucleus (ARC)-restricted TLR4 knockdown improves obesity-related metabolic disorders remains unexplored. In this study, we used TLR4 shRNA lentiviral particles to suppress the TLR4 expression in the hypothalamic ARC of diet-induced obese rat model by stereotaxic injection. Our results demonstrate that ARC-restricted TLR4 knockdown protects obese rats from diet-induced weight gain and energy intake, from diet-induced impaired glucose homeostasis and peripheral insulin resistance, and from high-fat diet-induced hepatic steatosis and adipocyte hypertrophy. Thus, we define ARC-restricted TLR4 knockdown as a potential strategy to combat metabolic disorders associated with obesity.
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak
Authors: Mir Daiana , Delatorre Edson , Bonaldo Myrna , Lourenço-de-Oliveira Ricardo , Vicente Ana Carolina , Bello Gonzalo
Published: August 2017

Yellow fever virus (YFV) strains circulating in the Americas belong to two distinct genotypes (I and II) that have diversified into several concurrent enzootic lineages. Since 1999, YFV genotype I has spread outside endemic regions and its recent (2017) reemergence in non-endemic Southeastern Brazilian states fuels one of the largest epizootic of jungle Yellow Fever registered in the country. To better understand this phenomenon, we reconstructed the phylodynamics of YFV American genotypes using sequences from nine countries sampled along 60 years, including strains from Brazilian 2017 outbreak. Our analyses reveals that YFV genotypes I and II follow roughly similar evolutionary and demographic dynamics until the early 1990s, when a dramatic change in the diversification process of the genotype I occurred associated with the emergence and dissemination of a new lineage (here called modern). Trinidad and Tobago was the most likely source of the YFV modern-lineage that spread to Brazil and Venezuela around the late 1980s, where it replaced all lineages previously circulating. The modern-lineage caused all major YFV outbreaks detected in non-endemic South American regions since 2000, including the 2017 Brazilian outbreak, and its dissemination was coupled to the accumulation of several amino acid substitutions particularly within non-structural viral proteins.
Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease
Authors: Croft Cara L. , Kurbatskaya Ksenia , Hanger Diane P. , Noble Wendy
Published: August 2017

Organotypic brain slice culture models provide an alternative to early stage in vivo studies as an integrated tissue system that can recapitulate key disease features, thereby providing an excellent platform for drug screening. We recently described a novel organotypic 3xTg-AD mouse brain slice culture model with key Alzheimer’s disease-like changes. We now highlight the potential of this model for testing disease-modifying agents and show that results obtained following in vivo treatment are replicated in brain slice cultures from 3xTg-AD mice. Moreover, we describe novel effects of the amyloid-binding tetra (ethylene glycol) derivative of benzothiazole aniline, BTA-EG4, on tau. BTA-EG4 significantly reduced tau phosphorylation in the absence of any changes in the amounts of amyloid precursor protein, amyloid-β or synaptic proteins. The reduction in tau phosphorylation was associated with inactivation of the Alzheimer’s disease-relevant major tau kinase, GSK-3. These findings highlight the utility of 3xTg-AD brain slice cultures as a rapid and reliable in vitro method for drug screening prior to in vivo testing. Furthermore, we demonstrate novel tau-directed effects of BTA-EG4 that are likely related to the ability of this agent to inactivate GSK-3. Our findings support the further exploration of BTA-EG4 as a candidate therapeutic for Alzheimer’s disease.
Emergence of unusual coexistence states in cyclic game systems
Authors: Park Junpyo , Do Younghae , Jang Bongsoo , Lai Ying-Cheng
Published: August 2017

Evolutionary games of cyclic competitions have been extensively studied to gain insights into one of the most fundamental phenomena in nature: biodiversity that seems to be excluded by the principle of natural selection. The Rock-Paper-Scissors (RPS) game of three species and its extensions [e.g., the Rock-Paper-Scissors-Lizard-Spock (RPSLS) game] are paradigmatic models in this field. In all previous studies, the intrinsic symmetry associated with cyclic competitions imposes a limitation on the resulting coexistence states, leading to only selective types of such states. We investigate the effect of nonuniform intraspecific competitions on coexistence and find that a wider spectrum of coexistence states can emerge and persist. This surprising finding is substantiated using three classes of cyclic game models through stability analysis, Monte Carlo simulations and continuous spatiotemporal dynamical evolution from partial differential equations. Our finding indicates that intraspecific competitions or alternative symmetry-breaking mechanisms can promote biodiversity to a broader extent than previously thought.
Stability of volcanic ash aggregates and break-up processes
Authors: Mueller Sebastian B. , Kueppers Ulrich , Ametsbichler Jonathan , Cimarelli Corrado , Merrison Jonathan P. , Poret Matthieu , Wadsworth Fabian B. , Dingwell Donald B.
Published: August 2017

Numerical modeling of ash plume dispersal is an important tool for forecasting and mitigating potential hazards from volcanic ash erupted during explosive volcanism. Recent tephra dispersal models have been expanded to account for dynamic ash aggregation processes. However, there are very few studies on rates of disaggregation during transport. It follows that current models regard ash aggregation as irrevocable and may therefore overestimate aggregation-enhanced sedimentation. In this experimental study, we use industrial granulation techniques to artificially produce aggregates. We subject these to impact tests and evaluate their resistance to break-up processes. We find a dependence of aggregate stability on primary particle size distribution and solid particle binder concentration. We posit that our findings could be combined with eruption source parameters and implemented in future tephra dispersal models.