bluuebunny/crossref_metadata_2025 huggingface dataset:
Misión profética del pensamiento social cristiano en la era digital
Authors: Díaz de la Cruz Cristina , Fernández Fernández José Luis
Published: October 2019

La Iglesia Católica ha desarrollado, fundamentalmente a lo largo de las últimas décadas, un aporte significativo para la reflexión acerca de cómo construir relaciones políticas, económicas y sociales basadas en los valores del Evangelio, por el bien de la humanidad. En 1967 el Papa Pablo VI publicó la carta encíclica Populorum Progressio donde explicitaba las condiciones, desde la perspectiva de la Iglesia, para que pueda darse un verdadero desarrollo, indicando que “para que sea auténtico ha de ser integral, de todo el hombre y de todos los hombres” (n. 14). Desde la publicación de esta carta se han producido cambios significativos en el mundo empresarial, especialmente en relación con la globalización y el advenimiento de la llamada era digital. Sin embargo, las claves profundas de la propuesta de Pablo VI, de otros textos de la Doctrina Social de la Iglesia y de la antropología cristiana, siguen siendo actuales. El pensamiento social cristiano tiene por misión iluminar, a modo de profecía, la acción humana en este entorno, que sufre transformaciones cada vez más rápidas. Este estudio pretende ofrecer, desde la perspectiva cristiana, algunas claves que puedan servir de guía para la toma de decisiones, sobre todo para el entorno empresarial, en tiempos de cambios e incertidumbres propios de la llamada era digital. Como resultado, el artículo ofrece tres propuestas para la promoción del desarrollo humano integral en el contexto anteriormente citado: desenmascarar las ideologías, ofrecer un claro modelo de ser humano abierto a la transcendencia y fomentar la cooperación intergeneracional.
Babel
Authors: Estrada Pedro Arturo
Published: October 2019

Y tantos libros, tantos nombres
desbordando la estrecha memoria de un mundo
hecho sólo de ráfagas de presente
Presentación
Authors: Zuluaga Mesa David Esteban
Published: October 2019

El presente número de Perseitas, correspondiente al periodo julio-diciembre de 2019, está conformado por cinco artículos de investigación, uno de reflexión no derivado de investigación, un poema y, por supuesto, una editorial: “Venir a la palabra” (Jaramillo Restrepo, 2019), enfocada en reflexionar en torno a la filosofía como medicina como una posibilidad de pensar los problemas de salubridad en el plano de las relaciones interpersonales y de auto-reflexión sobre los actos y sus consecuencias en la vida de las personas.
Thermal properties of commercial hydrobionts’ tissues in the freezing process
Authors: Bogdanov Valery , Simdyankin Andrei
Published: October 2019

The paper describes changes in thermal properties in the process of freezing of marine raw materials. The study objects were the skin of giant octopus (Octopus dofleini L.), pallium of Pacific squid (Todarodes pacificus L.), milt of Pacific herring (Clupea pallasii L .), a nd muscle t issue of Japanese c ucumaria (Cucumaria japonica L.). The mathematical relations of the studied thermal parameters allowing the calculation of specific heat capacity, thermal conductivity coefficient and tissue density of the studied objects in the process of freezing were obtained. It was found that the change in the total specific heat capacity during the freezing of all the objects under study was of the same type: first, this figure increases due to the intensive ice formation in the tissues of hydrobionts, and then decreases due to a significant decrease in the content of the liquid aqueous phase. The values of the total specific heat capacity before the freezing of seafood were determined (kJ/kg·K): 4.26 for squid, 3.58 for milt of Pacific herring, 3.66 for octopus skin, and 3.95 for the shell of cucumaria. It was revealed that an increase in the amount of frozen out water decreased the density of samples of frozen raw materials. This was due to the high (77.4–88.9%) content of water, turning into ice, which has a lower density index. The values of hydrobionts’ tissue density before freezing were obtained ( 0 ρ , kg/m3): 1226.74 for squid, 1209.6 for milt of Pacific herring, 1128.55 for octopus skin, and 031.26 for shell of cucumaria. It was established that the thermal conductivity of the hydrobiont tissue samples in the process of freezing increased with the growth of the proportion of frozen out water contained, approaching the thermal conductivity of ice. The calculated values of thermal conductivity coefficient of seafood tissue prior to freezing equal (W/m·K): 0.52 for squid, 0.47 for milt of Pacific herring, 0.63 for octopus skin, and 0.53 for cucumaria. The obtained thermal characteristics values of the objects studied are recommended for use in technical and technological calculations of aquatic biological resources cooling treatment processes.
New technological paradigm of the Russian dairy industry: formation principles under globalisation
Authors: Khramtsov Andrey
Published: October 2019

The present research employed a convergent approach and cognitive methodology to define the upgrade options in the sphere of domestic dairy industry according to the principles of the 5th technological paradigm. The principles include biological nanomembrane cluster technologies with a complete production cycle. The paper offers a forecast for the 6th technological paradigm, which presupposes picotechnology for the production of milk derivatives, such as lactose hydrolysates, lactulose, microparticulate proteins, peptides, and amino acid pool. The principle makes it possible to return secondary dairy raw materials into the technological cycle. These significant resources include low-fat milk, buttermilk, and especially whey, which can be used to produce functional foods for various population groups, as well as new generation forage resources. From the point of view of logistics, the modern dairy industry should employ a digital and robot-aided non-waste production scheme. Thus, all dairy raw materials should be considered as natural clusters according to the nature-formed biotechnological system (BTS). These clusters are lipids (fats), nitrogencontaining substances (proteins), carbohydrates (lactose), minerals (salt), biologically active substances, and water. As an idealised model of agricultural raw material, milk is extremely complex. Its chemical composition includes more than 2000 constituents and 100000 molecular structures. In addition, dairy architectonics is also extremely complex: milk is suspension, emulsion, and solution, concurrently. Finally, milk possesses unusual physicochemical, osmophoric, structural-mechanical, bio-thermodynamic, and other characteristics. We conducted a long-term systematic analysis and developed a scheme that can help the domestic diary industry to adapt safely to the new technological paradigm. The scheme takes into account various factors, such as limited traditional dairy resources, Russia’s accession to the WTO, and the globalisation of the world dairy market. Our research team belongs to the leading federal scientific school ‘Living Systems’ (No.7510.2010.4) developed by the North Caucasus Federal University (Russia).
Effect of pre-treatment conditions on the antiatherogenic potential of freeze-dried oyster mushrooms
Authors: Piskov Sergey , Timchenko Lyudmila , Rzhepakovsky Igor , Avanesyan Svetlana , Bondareva Nadezhda , Sizonenko Marina , Areshidze David
Published: October 2019

Oyster mushroom (Pleurotus ostreatus L.) is a valuable food product. It possesses an antiatherogenic potential, which has to be preserved during processing. The paper features the production of oyster mushroom sublimates. It focuses on such pre-treatment conditions as grinding, disinfection, and cryostabilisation, and their effect on the antiatherogenic potential of oyster mushrooms. A set of in vitro experiments was performed to measure the levels of lovastatin and antioxidant, catalase, anti-inflammatory, and thrombolytic properties. Various pre-treatment conditions proved to produce different effects on the biological activity of the freeze-dried oyster mushroom product. The best results were obtained after the mushrooms were reduced to pieces of 0.5 cm, underwent UV disinfection, blanched, treated with hot air, and cryostabilised with a 1.5% apple pectin solution. The best conditions for the antioxidant properties included ozonation, UV disinfection, and cryoprotection with pectin. The critical conditions for the antioxidant properties included homogenisation, blanching, and cryostabilisation with 10% solutions of sucrose and lactose. The catalase properties did not depend on the degree of grinding and were most pronounced after ozonation. The optimal conditions for the anti-inflammatory properties included UV disinfection and cryostabilisation with lactose. Ozonation proved to be critical for anti-inflammatory properties. The optimal conditions for thrombolytic properties included ozonation and cryoprotection with a 5% sorbitol solution, while hot air disinfection proved critical. Therefore, the research provided an experimental substantiation for individual pre-treatment conditions or their combinations that turn sublimated oyster mushrooms into a valuable functional product with antiatherogenic properties.
Functional dairy products enriched with plant ingredients
Authors: Sukhikh Stanislav , Astakhova Lidiia , Golubcova Yuliya , Lukin Andrey , Prosekova Elizaveta , Milent`eva Irina , Kostina Natalia , Rasshchepkin Aleksandr
Published: October 2019

Milk and dairy products are staple foods in the diet of all social groups. Plant additives are of multifunctional use in the dairy industry. Wild plants are a source of vitamins, minerals, and other biologically active substances. Due to these compounds, they improve digestion, cardiovascular activity, and emotional state. This review describes the latest trends in creating functional milk drinks enriched with plant components. They include drinks based on whole milk and cream, dairy by-products (whey, buttermilk), as well as fermented milk drinks with probiotic cultures (kefir, drinking yogurt). We found that aqueous extracts were most commonly introduced into milk raw materials. Fruits and berries were dried and added to milk raw materials in the powder form. Special attention was paid to ‘hairy roots’ as a promising technology for producing various functional foods. In addition to being economically viable, this technology can help us expand the range of plant materials with endangered species. Functional milk-based drinks enriched with plant extracts can improve the immune system and be used as part of supportive therapy. They are also suitable for daily use to replenish the balance of essential nutrients. These properties make their production a promising direction in the dairy industry.
Experiencia de pacientes con diabetes e hipertensión que participan en un programa de telemonitoreo
Authors: Gallardo-Zanetta Ana María , Franco-Vivanco Pamela Verónica , Urtubey Xavier
Published: October 2019

Objetivo: conocer la experiencia de personas con diabetes mellitus o hipertensión, pertenecientes a un programa de telemonitoreo. Método: diseño cualitativo a través de grupos focales a usuarios del Servicio de Salud Pública en Santiago de Chile. Participaron 46 personas distribuidas en 10 grupos. Resultados: estos se orientan a los beneficios percibidos de participar en el programa: promoción de rutinas de cuidado de la salud, aprendizaje sobre el manejo de su enfermedad, empoderamiento frente a los servicios de urgencia, apoyo percibido por parte del equipo de salud del servicio de telemonitoreo, integración de la familia a los cuidados de la salud, comodidad y accesibilidad; y posibles barreras percibidas para ingresar o permanecer en el programa. Conclusión: este es el primer estudio en Chile sobre la experiencia de pacientes con enfermedades crónicas pertenecientes a un programa de telemonitoreo. Los resultados dan cuenta de la aceptación y utilidad del programa en el seguimiento de sus enfermedades y son un aporte fundamental para el perfeccionamiento y desarrollo de estos programas.
Influencia de la temperatura ambiental en el mosquito Aedes spp y la transmisión del virus del dengue
Authors: Márquez Benítez Yusselfy , Monroy Cortés Katherine Johana , Martínez Montenegro Edna Geraldine , Peña García Víctor Hugo , Monroy Díaz Ángela Liliana
Published: October 2019

En esta revisión se aborda a Aedes, el género de insectos más relevante en relación a la transmisión de agentes patógenos virales entre los que se cuentan dengue, zika, chikungunya, fiebre amarilla, entre otros. Este vector posee una rápida tasa de desarrollo y alta supervivencia, las cuales puede variar en respuesta a muchos factores bióticos y abióticos del ambiente. Entre estos últimos está la temperatura, la cual puede ejercer una considerable influencia en la capacidad vectorial, ya que impacta en la dinámica de la población del mosquito, la cinética del ciclo biológico, la respuesta inmunológica frente al virus del dengue, entre otros aspectos. Este conocimiento puede resultar útil en la realización de mejores proyecciones de los efectos del cambio climático sobre la incidencia del dengue, así como lograr una detección temprana de posibles brotes epidémicos que permitan la planeación oportuna de una respuesta rápida y eficaz para lograr la reducción y el control de la enfermedad.
Xantomas, la pieza clave para el diagnóstico de una hipertrigliceridemia grave
Authors: González-Arango Juanita , Darío Aguirre Hernán , Mejía Ana María , Márquez-Morón María Del Pilar , Peña-Zuñiga Elsa Bibiana
Published: October 2019

La hipertrigliceridemia grave es una entidad poco común que presenta complicaciones que varían desde xantomas eruptivos y lipemia retinalis hasta pancreatitis, la cual puede llegar a ser mortal. No hay valores absolutos de niveles de triglicéridos con los que los pacientes desarrollen complicaciones, por lo que es difícil determinar la necesidad de manejo intrahospitalario en pacientes asintomáticos. Presentamos el caso de un paciente de 47 años con hipertrigliceridemia grave, quien como único signo clínico presentaba xantomas generalizados. Se realiza una discusión del tema y revisión de la literatura.
Las cualidades de un médico
Authors: Castaño-Osorio Jacobo
Published: October 2019

Creo que la cualidad más importante de un médico es amar, amar lo que hace, amar las personas y amarse a sí mismo, vivir para el servicio, vivir para ayudar a vivir mejor a otros, vivir para amar, respetar y curar y siempre con una sonrisa y aunque vengan momentos en los que quieras tirar la toalla y no te creas capaz de nada mas, recuerda por quién estas ahí y porque estás ahí, recuerda cada momento en el cual viste a una persona salir de una enfermedad que tú trataste y recuerda la sensación que te dio al verle su cara brillante de la felicidad y agradecimiento hacia ti. Recuerda a dónde quieres llegar y cómo quieres ser, y nunca olvides amar.
«New normality» as a step in the evolution of China's economic model
Authors: Milenkiy Aleksandr Vsevolodovich , Li Chen
Published: October 2019

The article discusses the current stage of evolution of China’s economic model which is called the «New normality». The author emphasizes that «New normality» is the stage of creating a new economic development model, involving the process of changing the extensive type of economic growth through the use of cheap labor power to the intensive type based on innovations, growing domestic demand. The conditions of transition to a new model, changes in economic policy, and the result that they want to achieve when implementing this model to the Chinese economy are shown.
COMMUNICATION PECULIARITIES OF ADOLESCENTS ATTENDING IN DANCE ACTIVITIES
Authors: Uspuriene Aiste Barbora
Published: October 2019

Dance is related to the peculiarities of communication between teenagers, because the essence of these dances is the performance of dance in a couple, During dance classes, adolescents have the opportunity to acquire excellent communication skills, to consciously discover and improve their weak points, to raise their communication level to a higher, more enjoyable level, There is lack of literature on communication between dancers of all ages and skill levels, There is a significant lack of scientific data on the impact of dance on adolescent communication.
Capitales británicos y producción agraria en espacios de frontera. Bahía Blanca, Argentina (1860-1900)
Authors: Costantini Florencia
Published: October 2019

Con el objetivo de problematizar el proceso modernizador del sur bonaerense argentino, el siguiente artículo investiga el rol que tuvieron las inversiones británicas en la economía rural en el partido de Bahía Blanca entre 1860 y 1900. La metodología empleada es microanalítica y se vale de herramientas provenientes del estudio hermenéutico de documentos, reconstrucción de trayectorias personales y del análisis estadístico. Abordados en su dimensión diacrónica podemos detectar dos modos de intervención del capital británico en la región que se suceden en el tiempo y que fueron acompañados por formas particulares de inmigración: la inversión en estancias y la presencia de compañías legalmente autónomas. Aunque de modo diferencial, ambos momentos propiciaron la producción agropecuaria a gran escala acelerando el corrimiento de la frontera productiva con impactos en los grupos sociales locales como los comerciantes internos de frutos del país y cereales.
Role of Cellular Biomolecules in Screening, Diagnosis and Treatment of Colorectal Cancer
Authors: Mei Xiang-Lin , Zheng Qing-Fan
Published: October 2019

Background:

Prevention is the primary strategy to avoid the occurrence and mortality of colorectal cancer.
Generally, the concentrations of tumor markers tested during the diagnosis and believed to assist the detection of
disease in the early stages of cancer. Some of the biomarkers are also important during treatment and real-time monitoring
of the progress of treatment.

Methods:

We considered a rationale search of key references from the database of peer-reviewed research and review
literatures of colorectal cancer. The topic of search was focused on the novel methods and modern techniques
of Screening, Diagnosis, and Treatment of colorectal cancer. The screened publications were critically analysed
using a deductive content analysis and the matter was put in separate headings and sub headings.

Results:

It was found that endoscopic examination, early detection, and surgery are some of the common strategies to
manage colorectal cancer because late stages are difficult to treat due to the high-cost requirement and fewer chances
of survival. As far as chemotherapy is concerned, systemic chemotherapy has been shown to offer the maximum
benefit to patients with cancer metastasis. Among different chemotherapy measures, primary colorectal cancer prevention
agents involve pharmaceuticals, phytochemicals, and dietary supplements are some of the standard options.

Conclusion:

In this review article, we have provided a comprehensive analysis of different biomarkers for the detection
of colorectal cancer as well as different formulations developed for efficient treatment of the disease. The use of
dietary supplements, the combinatorial approach, and nanotechnology-based strategies for colorectal cancer diagnosis
and treatment are some of the recent and modern methods of cancer management.
In Silico Identification of Novel Flavonoids Targeting Epidermal Growth Factor Receptor
Authors: Shah Ashish , Seth Avinash Kumar
Published: October 2019

Background:

Epidermal growth factor receptor (EGFR, ErBb) belongs to family of receptor
tyrosine kinase (RTKs) that plays an important role in multiple cell signaling pathways,
which includes cell growth, multiplication apoptosis, etc. Overexpression of EGFR results in development
of malignant cells. Therefore, EGFR is considered one of the important target for cancer
therapy.

Objective:

In this study, virtual screening of 329 flavonoids obtained from the Naturally Occurring
Plant-based Anti-cancer Compound-Activity-Target (NPACT) database had been performed to
identify novel EGFR inhibitors.

Materials and Methods:

Virtual screening of flavonoids were carried out using different in silico
methods, which includes molecular docking studies, prediction of druglikeness, in silico toxicity
studies and bioactivity prediction.

Results:

Six flavonoids NPACT00061, NPACT00062, NPACT00066, NPACT00280,
NPACT00700 and NPACT00856 were identified as potential EGFR inhibitors with good docking
score and druglikeness properties. In the in silico toxicity studies, compound NPACT00061,
NPACT00062, NPACT00066 and NPACT00856 were found to be carcinogenic. Finally, two flavonoids
NPACT00280 and NPACT00700 were recognized as novel EGFR inhibitors.

Conclusion:

Our findings suggest that compound NPACT00280 and NPACT00700 could be further
explored as novel EGFR inhibitors.
Influence of β-D-mannuronic Acid, as a New Member of Non-steroidal Anti- Inflammatory Drugs Family, on the Expression Pattern of Chemokines and their Receptors in Rheumatoid Arthritis
Authors: Aslani Mona , Ahmadzadeh Arman , Aghazadeh Zahra , Zaki-Dizaji Majid , Sharifi Laleh , Hosseini Mostafa , Mirshafiey Abbas
Published: October 2019

Background: :

Based on the encouraging results of phase III clinical trial of β-Dmannuronic
acid (M2000) (as a new anti-inflammatory drug) in patients with RA, in this study, we
aimed to evaluate the effects of this drug on the expression of chemokines and their receptors in
PBMCs of RA patients.

Methods::

PBMCs of RA patients and healthy controls were separated and the patients' cells were
treated with low, moderate and high doses (5, 25 and 50 μg/mL) of M2000 and optimum dose (1
μg/mL) of diclofenac, as a control in RPMI-1640 medium. Real-time PCR was used for evaluating
the mRNA expression of CXCR3, CXCR4, CCR2, CCR5 and CCL2/MCP-1. Cell surface expression
of CCR2 was investigated using flow cytometry.

Results::

CCR5 mRNA expression reduced significantly, after treatment of the patients' cells with
all three doses of M2000 and optimum dose of diclofenac. CXCR3 mRNA expression was downregulated
significantly followed by the treatment of these cells with moderate and high doses of
M2000 and optimum dose of diclofenac. CXCR4 mRNA expression declined significantly after
the treatment of these cells with moderate and high doses of M2000. CCL2 mRNA expression significantly
reduced only followed by the treatment of these cells with a high dose of M2000,
whereas, mRNA and cell surface expressions of CCR2 diminished significantly followed by the
treatment of these cells with a high dose of M2000 and optimum dose of diclofenac.

Conclusion::

According to our results, M2000 through the down-regulation of chemokines and
their receptors may restrict the infiltration of immune cells into the synovium.
Synthesis of Indolyl Pyrazole Scaffolds as Potential Anti-cancer Agents and their Molecular Modelling Studies
Authors: Gaddam Ganga Reddy , Dubey Pramod Kumar , Chittireddy Venkata Ramana Reddy
Published: October 2019

Background::

Indole and pyrazoles are one of the prime structural units in the field of
medicinal chemistry and have been reported to exhibit a variety of biological activities specifically
anti-cancer. In view of their medicinal significance, we synthesized a conjugate of the two moieties
to get access to newer and potential anti-cancer agents.

Methods:

Indolyl pyrazoles [3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(1-methyl-1H-indole-3-carbon
yl)acrylonitriles] (4a-l) were synthesized by adopting simple and greener protocol and all the synthesized
derivatives were docked against Bcl-2 protein and the selected chemical moieties were
screened for their cytotoxicity by using the MTT assay.

Results: :

All the synthesized compounds were docked against BCL-2 protein in order to understand
their binding pattern. Among the 12 compounds docked, 4d, 4f, 4h, 4j, and 4l compounds exhibited
better protein binding interactions and the same were screened for their anti-cancer activity against
A549 (lung) cancer cell lines at a concentration of 100 μM using Doxorubicin as standard. Substitutions
such as N-benzyl, N-ethyl groups and halogen groups such as Br, Cl on indole ring showed
moderate activity against A-549 cell lines.

Conclusion::

Among the 5 indolyl pyrazole derivatives screened, compounds 4h and 4j showed significantly
better activity with an IC50 of 33.12 and 34.24 μM, respectively. Further, structural tweaking
of the synthesized new chemical entities may lead to potential hit/lead-like molecules.
First Line Treatments for Newly Diagnosed Primary Immune Thrombocytopenia in Children: A Systematic Review and Network Meta-analysis
Authors: Acero-Garcés David O. , García-Perdomo Herney A.
Published: October 2019

Background:

The first-line interventions in immune thrombocytopenia (ITP) include
intravenous polyclonal immunoglobulins (IVIg), corticosteroids and anti-D immunoglobulin
(anti-D).

Objective:

We aimed to compare the effectiveness and safety of first line treatments for newlydiagnosed
primary ITP in children to increase the platelet count.

Methods:

We searched MEDLINE, EMBASE, LILACS and the Cochrane Central register of Controlled
Trials (CENTRAL); and included the clinical trials. We performed the statistical analysis
in R.

Results:

We included 12 studies for meta-analysis. Compared with IVIG 2g/kg, response rates
were lower for prednisone 2mg/kg at 72 hours [RR 0.04 (95% CI 0.0 to 0.68)] and at 7 days [RR
0.23 (95% CI 0.08 to 0.67)]; at 48 hours, methylprednisolone 30mg/kg also showed lower response
rates [RR 0.72 (95% CI 0.52 to 0.99)]. IVIG 2g/kg and 2.5g/kg had less adverse effects than Anti-
D, methylprednisolone and IVIG 0.8g/kg. For rising platelet count, no statistical differences were
found at 24 hours or in 7 days; at 48 hours, IVIG 2g/kg showed better results than Anti-D 75μg/kg
[MD -58.84 (95% CI -87.02 to -25.66)]. After a month, platelet count with IVIG 2g/kg was higher
than Anti-D 50 and 75μg/kg [-82.03 (95% CI -102.60 to -61.46) and -78.77 (95% CI -97.80 to -
59.74), respectively], but lower than methylprednisolone 50mg/kg [MD 118 (95% CI 3.88 to
232.12)].

Conclusion:

The total platelet count rises higher in early and late phases with IVIG than Anti-D,
but in long term it is higher with methylprednisolone. Additionally, IVIG causes less adverse effects
than Anti-D and corticosteroids.
QSPR Models for the Prediction of Some Thermodynamic Properties of Cycloalkanes Using GA-MLR Method
Authors: Joudaki Daryoush , Shafiei Fatemeh
Published: October 2019

Aim and Objective:

Cycloalkanes have been largely used in the field of medicine, components
of food, pharmaceutical drugs, and they are mainly used to produce fuel.

In present study the relationship between molecular descriptors and thermodynamic properties such as the standard enthalpies of formation (∆H°f), the standard enthalpies of fusion (∆H°fus), and the standard Gibbs free energy of formation (∆G°f)of the cycloalkanes is represented.

Materials and Methods:

The Genetic Algorithm (GA) and multiple linear regressions (MLR) were
successfully used to predict the thermodynamic properties of cycloalkanes. A large number of molecular
descriptors were obtained with the Dragon program. The Genetic algorithm and backward
method were used to reduce and select suitable descriptors.

Results:

QSPR models were used to delineate the important descriptors responsible for the properties
of the studied cycloalkanes. The multicollinearity and autocorrelation properties of the descriptors
contributed in the models were tested by calculating the Variance Inflation Factor (VIF),
Pearson Correlation Coefficient (PCC) and the Durbin–Watson (DW) statistics. The predictive
powers of the MLR models were discussed using Leave-One-Out Cross-Validation (LOOCV) and
test set validation methods. The statistical parameters of the training, and test sets for GA–MLR
models were calculated.

Conclusion:

The results of the present study indicate that the predictive ability of the models was
satisfactory and molecular descriptors such as: the Functional group counts, Topological indices,
GETAWAY descriptors, Constitutional indices, and molecular properties provide a promising
route for developing highly correlated QSPR models for prediction the studied properties.
Diospyros lotus-mediated Synthesis of Iron Oxide Nanoparticles and Their Application as a Catalyst in Fenton Reaction
Authors: Batool Sadaf , Hussain Zakir
Published: October 2019

Background: :

Iron Oxide nanoparticles have enormous applications in environmental remediation
and catalysis. The synthesis of such nanoparticles through a green approach provides a
significant advantage due to the non-toxic nature of the ingredients involved.

Method: :

In the present work, Diospyros lotus fruit extract was used for the synthesis of iron oxide
nanoparticles (NPs). The plant biomolecules were extracted employing two different solvents, i.e.
water and methanol. The effect of both the extracts on the reduction of metal salt as well as on the
shape and size of the produced NPs was investigated.

Results::

UV-Visible spectroscopy confirmed the synthesis of iron oxide NPs, Fourier Transform
Infrared (FTIR) spectrum depicted the presence of biomolecules on the surface of NPs as capping
agents, X-ray Diffraction (XRD) diffractogram confirmed the crystalline structure of mixed iron
oxide NPs and Scanning Electron Microscopy (SEM) images showed the spherical shape of NPs.
The synthesized NPs were exploited to catalyze the degradation of methylene blue dye in the Fenton
type catalytic reaction. The degradation reaction was monitored using UV-Visible spectroscopy,
which indicated that the percent degradation increased from 15% (without iron oxide NPs) to 91% in
the presence of organic extract prepared iron oxide NPs and to 81% in the presence of aqueous extract
prepared iron oxide NPs. The effect of the concentration of methylene blue and iron oxide NPs
on the degradation process was also investigated.

Conclusion: :

The results indicated the potential of synthesized nanoparticles to promote catalytic
reactions involved in environmental remediation.
Arg753Gln Polymorphisms in the Toll-Like Receptor 2 Gene are Associated with Cytomegalovirus Infection in Egyptian Bone Marrow Recipients
Authors: El-Nabi Sobhy Hassab , Sayed Samia , Abd-Elhafez Mohamed A. , Elfiky Mohamed , Abdel Moneim Ahmed E. , El-Garawani Islam
Published: October 2019

Background:

Previous studies have shown that cytomegalovirus (CMV) induced innate
immune response via activation of Toll-like receptor 2 (TLR2). The association between CMV among
specific single-nucleotide polymorphisms (SNPs) in the TLR2 gene was also investigated.

Objective:

This study investigated the relationship between specific SNPs in the TLR2 gene (G>A),
TLR2-Arg753Gln (rs5743708), and CMV replication after bone marrow transplantation.

Methods:

The TLR2-Arg753Gln SNP was genotyped in 181 patients after bone marrow transplantation:
83 and 98 patients with and without CMV infection, respectively. CMV load was determined in
serially collected blood samples using real-time PCR. Genotyping was performed using specific sequence
primer PCR (SSP-PCR), and the results were confirmed by restriction fragment length polymorphism
(RFLP) analysis of the PCR-amplified fragments for GG (wild type), GA and AA identification.

Results:

Roughly, 85% of the patients screened for the presence of the TLR2-Arg753Gln were GG
homozygous, and 15% were GA heterozygous; no patients were homozygous for the mutant allele (A).
The GA heterozygous allele was more frequent in the CMV-infected group after bone marrow transplantation.

Conclusion:

To our knowledge, this is a novel observation that supports the notion that the functional
missense mutation (TLR2-Arg753Gln polymorphism) is possibly associated with CMV replication
after bone marrow transplantation. This suggests a role for TLR2 in the innate immune response of
human CMV infection in Egyptian bone marrow recipients..
Acute Toxicity and Efficacy of Nanomaterial based Decontamination Formulation Developed for Personal Decontamination against Chemical Warfare Agents
Authors: Gautam Anshoo , Prasad Gangavarapu K. , Singh Deeksha , Vijayaraghavan Rajagopalan
Published: October 2019

Background:

This study addresses the efficacy of nanomaterials based formulation developed for personal decontamination application against chemical warfare agents and used in Personal Decontamination Kit (PDK). It has the potential to decontaminate the skin of an individual, protective equipment, and small arms contaminated with chemical warfare agents. As this formulation has been developed for personal decontamination, risk of nanomaterial toxicity would always be there while sprinkling or applying to the affected area. It may get into the body through various routes specifically through the inhalation route.

Aim:

The aim of this study was to evaluate in vivo decontamination efficiency of the formulation and acute inhalation, intratracheal, intranasal, oral, dermal, and intraperitoneal toxicity of the formulation.

Materials and Methods:

14 days survival was recorded for the evaluation of decontamination efficiency of this formulation. Various endpoints were considered while assessing the toxicity of Nanomaterial Decontamination Formulation which include Organ Body Weight Index (OBWI), serum biochemical parameters, and respiratory variables like tidal volume, respiratory rate, time of inspiration, time of expiration, etc. LD50 of the formulation were also determined for various routes. As skin is the primary organ to come in contact with the decontaminant, its primary skin irritation response has also been determined in this study.

Results and Conclusion:

It was found that there is no gross acute toxicity observed at different doses. Though there were some changes in the initial respiratory pattern, they were all later recovered. The preliminary histological evaluation did not show any adverse effect on various organs after exposure with NDF.
Applications of Different Biomarkers in the Diagnosis of Drug-induced Liver Injury
Authors: Sharma Monika , Yadav Ishita , Sharma Chandra K.
Published: October 2019

Biomarkers perform a significant function in the process of drug development. Biomarkers have been utilized in the safety assessment of drugs in clinical practice and also for personalization of medicines. To recognize the relation among considerable biological processes as well as clinical outcomes, it is important to increase our potential of treatments for all ailments, in addition to our understanding of normal and healthy physiology. Since the 1980s, using biomarkers is essential for substitutional results in long term assessments of main maladies, for example, cancer, as well as illness related to the heart. Now a days, biomarkers are highly important for unifying discovery of the drug and day by day improvements. The importance of biomarkers is increasing gradually with the advancement of novel therapeutics for the treatment and prevention of a broad range of diseases in order to overcome hepatotoxicity. These biomarkers are extensively used for the identification of disease and the field of medical research. The use of biomarkers in clinical as well as basic research has been promoted rapidly by the different drug regulation authorities for better outcomes in the future.
Recent Advances and Current Developments of Molten Pool Temperature Measurement for Laser Additive Manufacturing Processes
Authors: Liu Zhichao , Li Tao , Kim Hoyeol , Cong Weilong , Jiang Qiuhong , Zhang Hong-Chao
Published: October 2019

Background:

Molten pool temperature in Laser Additive Manufacturing (LAM) will affect
powder efficiency, structural compositions of reactants and products in the molten pool, thus determining
the microstructure evolutions and mechanical properties of the final part. An interest in molten pool
temperature measurement has been around for a long time since the appearance of LAM. However, a
comprehensive summary of the existing methods and their applications does not exist in the literature.

Objective:

The state-of-the-art of the existed devices and methods for molten pool temperature measurement
in various of LAM processes is reviewed in this paper.

Methods:

The existing temperature measurement methods for molten pool monitoring in LAM processes
are discussed. For each method, the existed patents, detailed procedures, advantages and disadvantages,
specific applications are specified. In the end, comparisons among the current temperature
measurement techniques are made according to data accuracy, operation complexity and cost of implementation.

Results:

Four methods are currently being used for the molten pool temperature measurement in LAM
processes, including (i) Thermocouples, (ii) Infrared pyrometers, (iii) Infrared cameras, and (iv)
Charge-coupled-device cameras.

Conclusion:

Different measurement methods represent different characteristics of the signal, and each
has merits and defects. Selecting suitable measurement method according to different process characteristics
will be helpful to achieve a preferable and more convincing results.
Visual Fixations and Motion Sensitivity: Protocol for an Exploratory Study (Preprint)
Authors: Chaudhary Shikha , Saywell Nicola , Kumar Arun , Taylor Denise
Published: October 2019

BACKGROUND

Motion sensitivity after vestibular disorders is associated with symptoms of nausea, dizziness, and imbalance in busy environments. Dizziness and imbalance are reported in places such as supermarkets and shopping malls which have unstable visual backgrounds; however, the mechanism of motion sensitivity is poorly understood.

OBJECTIVE

The main aim of this exploratory observational study is to investigate visual fixations and postural sway in response to increasingly complex visual environments in healthy adults and adults with motion sensitivity.

METHODS

A total of 20 healthy adults and 20 adults with motion sensitivity will be recruited for this study. Visual fixations, postural sway, and body kinematics will be measured with a mobile eye tracker device, force plate, and 3D motion capture system, respectively. Participants will be exposed to experimental tasks requiring visual fixation on letters, projected on a range of backgrounds on a large screen during quiet stance. Descriptive statistics (mean and standard deviation) will be calculated for each of the variables. One-way independent-measures analyses of variance will be performed to investigate the differences between groups for all variables.

RESULTS

Data collection was started in May 2019 and was completed by February 2020. It was approved by Health and Disability Ethics Committees, Ministry of Health, New Zealand on November 2, 2018 (Ethics ref: 18/CEN/193). We are currently processing the data and will begin data analysis in July 2020. We expect the results to be available for publication by the end of 2020. The trial was funded by the Neurology Special Interest Group, Physiotherapy New Zealand, and the Eisdell Moore Centre in November 2018.

CONCLUSIONS

This study will provide a detailed investigation of visual fixations in response to increasingly complex visual environments. Investigating characteristics of visual fixations in healthy adults and those with motion sensitivity will provide insight into this disabling condition and may inform the development of new intervention strategies which explicitly cater to the needs of this population.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry, ACTRN12619000254190; https://tinyurl.com/yxbn7nks

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/16805
Numerical Study of Fluid Dynamics in Suspension Culture of iPS Cells
Authors: Yano Masaki , Yamamoto Takuya , Okano Yasunori , Kanamori Toshiyuki , Kino–oka Mashiro
Published: October 2019

In a suspension culture of iPS cells, the shear stress generated during mixing is expected to promote differentiation of induced pluripotent stem (iPS) cells. The stress on the cells can be controlled by rotational rate and shape of impeller. However, it is difficult to optimize these operative parameters by experiments. Therefore, we have developed a numerical model to obtain the average and the maximum shear stress in two kinds of stirred tanks and an orbital shaking cylindrical container. The present results showed that the shear stress strongly depended on the type of mixing and lesser extent on the shape of the impeller. The average shear stress is larger in the shaking mode than that in the stirring mode. In contrast, the maximum shear stress is much smaller in the shaking than the stirring. These results suggest that stirring and shaking should be selectively used depending on the application
Numerical Investigation on Multiphase Flows in Various Configurations of Microchannels Using Computational Fluid Dynamics
Authors: Majnis Mohd Fadhil , Jalwan Mohamad Rawad
Published: October 2019

A two-dimensional domain of multiphase flow analyses in this study using the Volume of Fluid (VOF) model was carried out in order to simulate and predict the fluid flows and mixing performance of two miscible liquids in various microchannel configurations. The various microchannels configurations were designed accordingly and the simulation was carried out based on the justified conditions, assumptions and considerations by using the commercial computational fluid dynamics (CFD) software, FLUENT. The grid type and size of the computational domain were verified in terms of stability by performing the grid independence analysis. The result showed that static mixing would be possible to achieve in various configurations of microchannels, however, the simulation results predicted that it appeared to be more efficient in complex and retrofitted microchannels. It showed the potential to promote and enhance chaotic advection, compositions distribution, and diffusivity as compared to basic microchannels that are mostly dependent only on the injection focus. Furthermore, the Reynolds number appeared to be a significant factor to enhance the mixing performance in microchannel beside the configurations.
The Development of Lithium Ion Recovery Method by Activated Carbon and Natural Zeolite-based Adsorbent
Authors: Purnomo Chandra Wahyu , Kesuma Endhy , Wirawan Sang Kompiang , Hinode Hirofumi
Published: October 2019

Coconut shell char and natural zeolite been activated and then tested to separate between lithium and cobalt ions in solutions. The capacity of adsorption and selectivity between the ions were investigated. The longer adsorption time, the capacity was getting better but the selectivity decreased. It was observed that the optimum selectivity was obtained by 3 hours adsorption using activated carbon. The chemical activated sample has superior performance and selectivity compared with physical activation carbons of the same activation temperature. After the adsorption, pure lithium solution can be obtained while the other metal is adsorbed inside the adsorbent
Effect of Pressure and Syngas Composition on Direct Synthesis of Dimethyl Ether using Dual Bed Catalyst
Authors: Ardy Aisyah , Rizkiana Jenny , Gunawan Melia  Laniwati , Susanto Herri
Published: October 2019

National General Energy Plan of Indonesia 2017 (RUEN 2017) stated that dimethyl ether (DME) is appointed as a blending of LPG to reduce LPG imports. DME can be made with two reaction pathways, namely direct synthesis and indirect synthesis. The objective of this study was to determine the effect of pressure and syngas composition on the direct synthesis of DME using dual fixed bed catalyst. The research was carried out with two types of catalyst: M-xxx as a commercial catalyst for methanol synthesis and γ-Al2O3 as catalyst for dehydration of methanol to DME. The later was prepared in our Laboratory of Chemical Reaction Engineering and Catalysis, ITB. The dual catalyst experiment was carried out at 5 and 7 bars, and a fixed temperature of 240oC. The mass ratio of the M-xxx to γ-Al2O3, so-called M/D ratios, were varied from 1/9 to 9/1. Two type of syngas were used, i.e. SA containing only H2 and CO with a SN of 2,3 and SB containing 4% CO2 with SN of 1,8. The dual bed with a M/D ratio of 1/4 gave a CO conversion up to 62% at 5 bars and 240oC (SA). As pressure increased, the conversion of CO and H2 increases to 85% and 83% at 7 bar and 240oC (SA). The presence of CO2 (SB) decreases catalyst activity, as indicated by the decrease in conversion of CO and H2 to 56% and 54%, at 7 bar and 240oC.
Nursing Ethics Education and Practice in the Niger Delta Region of Nigeria
Authors: McFubara, PhD Kalada Godson , Isabu, PhD Augustina Chikaodili
Published: October 2019

Whereas nursing profession helps the well and the sick regain independence as rapidly as possible, nursing ethics education provides the basis for effective professional practice.Objectives: This study sought to identify factors affecting nursing ethics education and to describe impact of nursing ethics education on nursing practice. Method: A descriptive cross sectional study was conducted, and two sets of questionnaires were developed and administered, one to 80 final year nursing students, the other to 60 nursing teachers in four universities. The questionnaires had 18 and 21 question items respectively covering demography of the respondents, knowledge from ethics education, factors affecting ethics education and impact of ethics education on nursing practice. Nominal scale data were collected and analyzed on a Microsoft Excel spread sheet. Frequencies and percentages of responses were calculated and tabulated under question categories.Results: Response rate was 86.3% for students and 51.7% for teachers. Although nursing ethics education is provided as a whole semester course, 51% of students and 80% of the teachers erroneously understand ethics as adherence to professional code of conduct. Even so 70% of both respondent groups were prepared to practice effective nursing. Meanwhile 82% of the students and 53% of teachers were of the view that professional negligence is a major ethical issue in practice. Conclusion: The nursing profession is committed to providing ethical practice, but the practitioners and their trainees lack the correct knowledge of what ethics really means. Due to this incorrect knowledge undue attention is being given to professional negligence. It is a challenge and may be giving rise to a protectionist practice. The inclusion of specialists in ethics or moral philosophy to teach nursing ethics as well as the adoption of dialogic and case study methods of teaching will avoid these challenges and enhance the proper understanding and application of principles and theories of ethics in nursing practice.