bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of a novel putative interaction partner of the nucleoporin ALADIN
Authors: Jühlen Ramona , Landgraf Dana , Huebner Angela , Koehler Katrin
Published: October 2016

It has been shown that the nucleoporin ALADIN plays a significant role in the redox homeostasis of the cell, but its function in steroidogenesis contributing to adrenal atrophy in triple A syndrome remains largely unknown. In an attempt to identify new interaction partners of ALADIN, co-immunoprecipitation followed by proteome analysis was conducted in different expression models using the human adrenocortical tumour cell line NCI-H295R. Our results suggest an interaction of ALADIN with the microsomal protein PGRMC2. PGRMC2 is shown to be activity regulator of CYP P450 enzymes and, therefore, to be a possible target for adrenal dysregulation in triple A syndrome. We show that there is a sexual dimorphism regarding the expression of Pgrmc2 in adrenals and gonads of wild-type (WT) and Aaas knock-out (KO) mice. Female Aaas KO mice are sterile due to delayed oocyte maturation and meiotic spindle assembly. A participation in meiotic spindle assembly confirms the recently investigated involvement of ALADIN in mitosis and emphasises an interaction with PGRMC2 which is a regulator of the cell cycle. By identification of a novel interaction partner of ALADIN, we provide novel aspects for future research of the function of ALADIN during cell cycle and for new insights into the pathogenesis of triple A syndrome.
Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
Authors: Beumer Joep , Clevers Hans
Published: October 2016

The intestinal epithelium is the fastest renewing tissue in mammals and has a large flexibility to adapt to different types of damage. Lgr5+ crypt base columnar (CBC) cells act as stem cells during homeostasis and are essential during regeneration. Upon perturbation, the activity of CBCs is dynamically regulated to maintain homeostasis and multiple dedicated progenitor cell populations can reverse to the stem cell state upon damage, adding another layer of compensatory mechanisms to facilitate regeneration. Here, we review our current understanding of how intestinal stem and progenitor cells contribute to homeostasis and regeneration, and the different signaling pathways that regulate their behavior. Nutritional state and inflammation have been recently identified as upstream regulators of stem cell activity in the mammalian intestine, and we explore how these systemic signals can influence homeostasis and regeneration.
Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers
Authors: Pearson Joseph C. , McKay Daniel J. , Lieb Jason D. , Crews Stephen T.
Published: October 2016

One of the key issues in studying transcriptional regulation during development is how to employ genome-wide assays that reveals sites of open chromatin and transcription factor binding to efficiently identify biologically relevant genes and enhancers. Analysis of Drosophila CNS midline cell development provides a useful system for studying transcriptional regulation at the genomic level due to a large, well-characterized set of midline-expressed genes and in vivo validated enhancers. In this study, FAIRE-seq on FACS-purified midline cells was performed and the midline FAIRE data were compared with whole-embryo FAIRE data. We find that regions of the genome with a strong midline FAIRE peak and weak whole-embryo FAIRE peak overlap with known midline enhancers and provide a useful predictive tool for enhancer identification. In a complementary analysis, we compared a large dataset of fragments that drive midline expression in vivo with the FAIRE data. Midline enhancer fragments with a midline FAIRE peak tend to be near midline-expressed genes, whereas midline enhancers without a midline FAIRE peak were often distant from midline-expressed genes and unlikely to drive midline transcription in vivo.
A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis
Authors: Kumar Namit , Srivillibhuthur Manasa , Joshi Shilpy , Walton Katherine D. , Zhou Anbo , Faller William J. , Perekatt Ansu O. , Sansom Owen J. , Gumucio Deborah L. , Xing Jinchuan , Bonder Edward M. , Gao Nan , White Eileen , Verzi Michael P.
Published: October 2016

During late gestation, villi extend into the intestinal lumen to dramatically increase the surface area of the intestinal epithelium, preparing the gut for the neonatal diet. Incomplete development of the intestine is the most common gastrointestinal complication in neonates, but the causes are unclear. We provide evidence in mice that Yin Yang 1 (Yy1) is crucial for intestinal villus development. YY1 loss in the developing endoderm had no apparent consequences until late gestation, after which the intestine differentiated poorly and exhibited severely stunted villi. Transcriptome analysis revealed that YY1 is required for mitochondrial gene expression, and ultrastructural analysis confirmed compromised mitochondrial integrity in the mutant intestine. We found increased oxidative phosphorylation gene expression at the onset of villus elongation, suggesting that aerobic respiration might function as a regulator of villus growth. Mitochondrial inhibitors blocked villus growth in a fashion similar to Yy1 loss, thus further linking oxidative phosphorylation with late-gestation intestinal development. Interestingly, we find that necrotizing enterocolitis patients also exhibit decreased expression of oxidative phosphorylation genes. Our study highlights the still unappreciated role of metabolic regulation during organogenesis, and suggests that it might contribute to neonatal gastrointestinal disorders.
Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A
Authors: Yoshimoto Rei , Kaida Daisuke , Furuno Masaaki , Burroughs A. Maxwell , Noma Shohei , Suzuki Harukazu , Kawamura Yumi , Hayashizaki Yoshihide , Mayeda Akila , Yoshida Minoru
Published: October 2016

Spliceostatin A (SSA) is a methyl ketal derivative of FR901464, a potent antitumor compound isolated from a culture broth of Pseudomonas sp. no. 2663. These compounds selectively bind to the essential spliceosome component SF3b, a subcomplex of the U2 snRNP, to inhibit pre-mRNA splicing. However, the mechanism of SSA's antitumor activity is unknown. It is noteworthy that SSA causes accumulation of a truncated form of the CDK inhibitor protein p27 translated from CDKN1B pre-mRNA, which is involved in SSA-induced cell-cycle arrest. However, it is still unclear whether pre-mRNAs are uniformly exported from the nucleus following SSA treatment. We performed RNA-seq analysis on nuclear and cytoplasmic fractions of SSA-treated cells. Our statistical analyses showed that intron retention is the major consequence of SSA treatment, and a small number of intron-containing pre-mRNAs leak into the cytoplasm. Using a series of reporter plasmids to investigate the roles of intronic sequences in the pre-mRNA leakage, we showed that the strength of the 5′ splice site affects pre-mRNA leakage. Additionally, we found that the level of pre-mRNA leakage is related to transcript length. These results suggest that the strength of the 5′ splice site and the length of the transcripts are determinants of the pre-mRNA leakage induced by SF3b inhibitors.
A sensitive 301V BSE serial PMCA assay
Authors: Gough Kevin C. , Bishop Keith , Somerville Robert A. , Hunter Nora , Maddison Ben C.
Published: October 2016

The prion strain 301V, is a mouse passaged form of bovine spongiform encephalopathy (BSE).  It has been used as a model of BSE for more than 20 years, in particular in the investigation of tissue distribution of infectivity, the molecular phenotype and transmission properties of BSE, strain typing assays and prion inactivation studies. Most 301V experiments have required murine bioassay as a method for the quantitation of infectivity. To date this model strain has not been studied with the protein misfolding cyclic amplification assay (PMCA) which detects prion-associated PrPSc protein. The detection of BSE PrPSc by PMCA can be more sensitive than mouse bioassay and is carried out in a much shorter time frame of days as opposed to months/years. Here, we describe the development of a new highly sensitive and specific PMCA assay for murine 301V and assess the sensitivity of the assay in direct comparison with murine bioassay of the same material. This in vitro assay detected, in a few days,  301V at a brain dilution of at least 1x10-9, compared to bioassay of the same material in VM mice that could detect down to a 1x10-8 dilution and took >180 days. The 301V PMCA may therefore offer a faster and more sensitive alternative to live animal bioassay when studying the BSE agent in VM mice.
Puzzles in modern biology. III. Two kinds of causality in age-related disease
Authors: Frank Steven A.
Published: October 2016

The two primary causal dimensions of age-related disease are rate and function. Change in rate of disease development shifts the age of onset. Change in physiological function provides necessary steps in disease progression. A causal factor may alter the rate of physiological change, but that causal factor itself may have no direct physiological role. Alternatively, a causal factor may provide a necessary physiological function, but that causal factor itself may not alter the rate of disease onset. The rate-function duality provides the basis for solving puzzles of age-related disease. Causal factors of cancer illustrate the duality between rate processes of discovery, such as somatic mutation, and necessary physiological functions, such as invasive penetration across tissue barriers. Examples from cancer suggest general principles of age-related disease.
Predicting socio-economic development of regions in the conditions of uncertainty
Authors: Абрамова  , Abramova Galina , Крюкова  , Kryukova Olga
Published: October 2016

In solving current economic problems predicting plays a significant role. The prospect of the development of the region depends on the ability to predict trends in the development of the situation and the results of management decisions. The article presents the main stages of predicting; important approaches of predicting practices are considered. The concepts of risk and uncertainty, as a major source of problems in predicting the social and economic processes, are revealed; the model choice of decisions under conditions of risk and uncertainty is marked, as well as the mathematical tools of decision making under uncertainty and risk; the factors affecting the quality of predicting the regional development are presented.
Formation of communication environment of socially focused non-profit organizations
Authors: Ульянова  , Ulyanova Irina
Published: October 2016

The author examines communication policy as one of the priorities of the socially focused organizations operating as in Russia as abroad. Some features of formation of communication environment of non-profit organizations are revealed. As part of the institutional matrix of the activities of NPOs the necessity of formation of communication culture of socially-focused organizations is shown as the basis of legal culture. The mechanism and the instruments of analysis of communication implementation are presented.
Democratic essence of local self-management as institute of democracy in the constitutional state
Authors: Худокормов  , Khudokormov Sergey
Published: October 2016

Clause is devoted to research of the democratic nature of local self-management in a context of methodology of a modern constitutional law. The author of clause proves the point of view, that local self-management is an independent form of democracy in the sense that, first, local communities possess the right to establishment of structure of institutions of local government, secondly, the constitution guarantees an autonomy of municipalities by transfer of powers of national representation directly against the population to elective bodies.
Healthcare law and ethics, 8: ethics, disability and DNAR
Authors: Barber Chris
Published: October 2016

‘Do not resuscitate’ (DNR) or ‘do not attempt resuscitation’ (DNAR) instructions being placed on patient's care notes may be quite common, particularly when to attempt resuscitation would either be futile, or against the patient's wishes. However, the placing of such instructions on a patient's care notes purely on the grounds of that patient's disability has major legal and ethical consequences. This article will explore the meaning of DNAR and highlight a small number of cases where a DNAR instruction has been applied on the grounds of a patient's disability. The roles of the HCA will be briefly suggested.
Hazards and risk: the support worker's role
Authors: Stonehouse David
Published: October 2016

Within this article, the author will be discussing the vital role that support workers have in managing risk and in maintaining a safe working environment for themselves, their colleagues and service users. The Code of Conduct for Healthcare Support Workers and Adult Social Care Workers in England ( Skills for Care and Skills for Health, 2013 ) clearly states the importance of health and safety in delivering care of the highest standards; relevant clauses of the Code will be identified.

The Health and Safety at Work etc. Act 1974 will be highlighted as being a key piece of legislation. The five steps of risk assessment will be discussed, to demonstrate how support workers can use this process to successfully manage risk in their working environments, while following workplace policies and procedures.
Flora da Bahia: Chloranthaceae
Authors: De Matos Lara Pugliesi , Giulietti Ana Maria , De Oliveira Reyjane Patrícia
Published: October 2016

The taxonomic treatment of Chloranthaceae from the Bahia state, Brazil, is presented here. Hedyosmum brasiliense is the only species of the family in Bahia. Descriptions, illustrations, notes and a distribution map of the species in the state are presented.
Governance: public governance to social innovation?
Authors: Massey Andrew , Johnston-Miller Karen
Published: October 2016

This paper reviews governance and public governance related to an emerging area of policy interest – social innovation. The European Commission’s White Paper on European Governance (2001) focused on openness, participation, accountability, effectiveness and coherence in public policy as characteristics of good governance. The EC has prioritised social innovation to address policy problems. Yet, the extant literature and research on social innovation is sparse. The paper questions whether it is a new mode of governance which contributes to good governance or a continuum of neoliberal reforms of the state which alters the relationship between the state, market and civil society.
Shades of individualisation: narratives of middle-class women in a Swiss urban context about the families ‘they live by’
Authors: Kellerhals Jean , Widmer Eric
Published: October 2016

This research presents various narratives about family configurations of middle-class women living in Geneva (Switzerland). The results are drawn from qualitative interviews of 22 women and mothers of a child aged between 6 and 13, who were part of a larger sample of female respondents from both first-time and stepfamilies. The research features five styles of narratives, with distinct ways by which the consequences of individualisation for family commitments and family relationality were played out. All narratives stressed autonomy and claims to self-development by family relationships. However, the contents and functions of such claims vary to a considerable extent. Some stress the importance of the family for the security it provides to individuals, while others see family as subordinated to individuals’ self-development and projects. Some emphasise the work of emotional care as central, whereas others consider the instrumental dimensions of family life more important. Some value equality between partners, and between parents and children, while others emphasise complementarity and specialisation between genders and generations as necessary. The styles of narratives are related to the life course experiences and resources of the respondents.
Enseñar a predicar en el siglo XVII. Encuentros y desencuentros entre los teóricos: Juan de Jesús M.ª (OCD) y Agustín de Jesús M.ª (OCD)
Authors: Díez Coronado María Ángeles
Published: October 2016

La predicación, entendida como la manera de convertir las Sagradas Escrituras en enseñanza de aplicación práctica para los fieles, cuenta con una larga historia que se remonta al siglo V d. C. En territorio hispánico esta disciplina vive uno de sus momentos álgidos en los Siglos de Oro, cuando el Concilio de Trento, la idiosincrasia de las órdenes religiosas y las ideas personales de los autores se combinan en la creación de unos manuales que se integran en el ámbito de la enseñanza y que en conjunto son un fiel reflejo del complejo panorama predicativo de la época. El análisis de los trabajos conciniatorios de Juan de Jesús M.ª y de Agustín de Jesús M.ª, carmelitas ambos y situados los dos cronológicamente en el siglo XVII, permiten corroborar esta realidad, a la par que dan luz sobre dos personajes singulares en su momento y sobre su obra predicativa, casi desconocida hoy día.
Aproximación histórica y metodológica a los cursos de pedagogía musical de la Universitat de les Illes Balears (1977-1990)
Authors: Gelabert Gual Llorenç
Published: October 2016

En la inercia del incipiente paradigma educativo gestado en España en la década de los setenta del siglo pasado, un grupo de músicos y profesores llevaron a cabo una iniciativa formativa con la intención de introducir la música en las escuelas de las Islas Baleares. Enmarcados en el ámbito no formal, estos cursos se convirtieron en el hilo transmisor de una nueva concepción pedagógica. Dicha concepción se basaba en las metodologías activas de vanguardia aplicadas con éxito en otros países de Europa y el especial vínculo de trabajo establecido con el entorno pedagógico del músico catalán Ireneu Segarra. Este artículo pretende aproximarnos al legado de esta oferta formativa desde las vertientes histórica y metodológica, remarcando también la potencialidad y utilidad de un formato de cursos similar a día de hoy, una vez desaparecida la especialidad del Maestro en Educación Musical en el nuevo marco de adaptación al Espacio Europeo de Educación Superior.
In-competencias de la Universidad occi-neo-liberal. De los sueños de Quintiliano a las pesadillas de Michel de Montaigne
Authors: González-Novoa Andrés
Published: October 2016

Las competencias educativas no están presentes en la literatura pedagógica hasta el Consenso de Washington. Surgen como concepto económico en el pensamiento de los fisiócratas franceses y concretamente en la Riqueza de las Naciones de Adam Smith. Texto donde destaca la asociación del concepto de individuo y de recursos humanos. Este intento por rentabilizar la educación no es nuevo y tiene un interesante precedente en la transición de la República al Imperio romano. Nace el sistema liberal de enseñanza en Las Instituciones Oratorias de Quintiliano y reaparecerá en el Renacimiento mediante los Studium Generale Universitas. Los ensayos de Michel de Montaigne y el callejón sin salida del humanismo nos mostrarán como el Plan Bolonia posee hondas raíces en la memoria de occidente al servicio de los presupuestos de la manufactura, el capitalismo, el liberalismo y, actualmente, de la globalización neoliberal.
O ÍNDICE DE DESENVOLVIMENTO DA EDUCAÇÃO BÁSICA E A INCIDÊNCIA DE POBREZA NOS MUNICÍPIOS DE PEQUENO PORTE DA REGIÃO SUL DO BRASIL
Authors: Soligo Valdecir
Published: October 2016

A interferência das condições sociais no rendimento escolar não é novidade para a ciência. O que motiva esta investigação é a insuficiência de estudos quantitativos com os dados disponibilizados pelo IBGE e INEP referentes à educação e às condições sociais da população brasileira como ferramentas de planejamento da gestão pública. O objetivo foi analisar em que medida e intensidade as condições sociais interferem no rendimento escolar. Para tanto foi utilizado regressão linear entre as variáveis: Incidência de Pobreza e Valor médio de IDEB para municípios com menos de 10 mil habitantes e que apresentam ambas as variáveis na Região Sul do Brasil. Como resultado, os valores indicam que há uma relação inversamente proporcional, demonstrando que, conforme aumentam os valores da Incidência de Pobreza, diminuem os valores Médios do IDEB. Outro aspecto revelado na pesquisa é a diferença entre os resultados da Região Sul e da análise de cada Unidade Federativa que compõem a Região em separado, indicando fragilidade das análises estatísticas de grande proporção.
UM TRABALHO DE SIMULAÇÃO DE OPERAÇÕES BANCÁRIAS NUM CENÁRIO INVESTIGATIVO COM ALUNOS DOS ANOS INICIAIS
Authors: Borges Fábio Alexandre , Da Silva Eliane Siviero
Published: October 2016

Com o presente relato de experiência, teve-se como objetivo investigar o potencial pedagógico possibilitado pela adoção de um cenário investigativo nos Anos Iniciais do Ensino Fundamental em aulas de Matemática. Para isso, foram trabalhadas atividades envolvendo as quatro operações fundamentais discutidas nos Anos Iniciais do Ensino Fundamental (adição, subtração, multiplicação e divisão), por meio de simulações de transações comerciais (compras e vendas), a partir da criação de uma moeda fictícia. O trabalho foi desenvolvido durante as aulas de Matemática no período vespertino, de uma turma de 5º ano de uma escola pública localizada no município de Moreira Sales/PR, contando com a participação de 21 alunos, com idades na faixa etária de 9 e 10 anos. Foi criada uma moeda local, denominada pelos alunos de Fisgraus e adquirida inicialmente por meio de uma troca de garrafas do tipo pet. Também foram trabalhados três problemas envolvendo as medidas de volume mililitros (ml) e  litros (l), aproveitando, com isso, o recolhimento de tais garrafas pet. Por fim, foi organizado em um dia uma venda de lanches, em que os alunos utilizaram as moedas adquiridas na troca das garrafas pet para a compra destes lanches. A partir da atividade desenvolvida, concluíu-se que o trabalho num cenário investigativo se mostrou um ambiente propício à aprendizagem, uma vez que houve o envolvimento dos alunos. Foi possível diagnosticar algumas das dificuldades apresentadas por eles com relação às quatros operações fundamentais (adição, subtração, divisão e multiplicação). Além disso, proporcionou-se um trabalho autônomo por parte dos alunos nas resoluções dos problemas.
Economic Dislocation and Resiliency on Prince Edward Island: Small Producer, Distant Markets
Authors: MacDonald Edward
Published: October 2016

In some ways the story of post-Confederation Prince Edward Island can be told as a search to find a replacement for the Island’s shipbuilding industry. For much of the nineteenth century, the export of locally constructed wooden sailing ships underpinned the colonial economy, providing widespread employment, enabling a profitable carrying trade and financing consumer expenditures. But in the late 1870s, the local shipbuilding industry essentially collapsed, squeezed between declining ship prices and freight rates, rising costs and competing technologies. Afterwards, the Island economy struggled to sustain itself, hampered by persistent out-migration, a small resource base and the state’s financial incapacity. Several new initiatives did provide partial answers to the Island’s economic dilemma. A case study of four industries – lobster fishing, fox farming, the seed potato industry and tourism – frames the issues facing Prince Edward Island in the century after 1873 and the strategies that the Islanders adopted to address them.
The Role of ‘the Public’ in the Management of Newfoundland’s Forestry Heritage
Authors: Kelly Erin
Published: October 2016

Forestry in Newfoundland has a long history of both subsistence and industrial uses, with separate associated tenure systems and property and use rights. Though most forest users on the island are subsistence or recreational users, the public plays only a minimal role in forest decision-making, which continues to revolve around industry-based harvesting decisions with little regard for the multiple forest uses valued by the public. With the rapid decline of the industrial pulp and paper sector, which has coincided with policy shifts from productivist to multifunctional forest uses, Newfoundlanders face difficult decisions regarding how to manage their forests, and for whom. This essay provides a brief history of forestry in Newfoundland, including recent changes to policies and practices on the island regarding public participation and ecosystem management. It frames some of the problems and solutions of forest governance as common-pool resource issues and suggests ways to better integrate existing forest users with forest management.
Investigación: Implicancias económicas y jurídicas del capital cooperativo sobre la base de normas internacionales de información financiera
Authors: Casabianca María Luz
Published: October 2016

El principio cooperativo de puertas abiertas otorga a las entidades delsector una característica única: los asociados se retiran y las cooperativastienen la obligación de reembolsar la cuota de capital. Esto generaun dilema respecto de la naturaleza contable de la cuenta ¿es pasivo opatrimonio neto? Asimismo, la naturaleza de la cuenta repercute jurídicay económicamente: ¿es indistinto trasladar el capital al pasivo? Argentinaresolvió legalmente que el capital cooperativo es patrimonio neto; mientrasque las normas contables internacionales lo consideran pasivo. Estadiferencia es un problema previsible para el caso de adoptar estándaresmundiales, pero de secuelas impensadas si no se actúa con anticipación.En el marco del Proyecto CAI+D 2011: Reconocimiento contabledel patrimonio neto. Implicancias económicas y jurídicas, patrocinadopor la Universidad Nacional del Litoral, se estudiaron las derivaciones detrasladar la cifra del capital al pasivo para proponer cambios legales oestatutarios. La metodología complementa la perspectiva empírica analíticacon la humanística–interpretativa, aplicada al caso de dos cooperativaslácteas ubicadas en la misma región, desde 2006 hasta 2014.Se analizaron indicadores sobre la base de estados contables preparadossegún normas nacionales y readaptados según las internacionales. Pudoobservarse una desmejora en función de los estándares internacionales que genera problemas frente al ingreso de mayor cantidad de asociadosy efecto en la comparabilidad de los estados contables con respecto deotros entes. El caso resulta útil para interpretar contablemente la realidad,poner en discusión la validez de la norma internacional en el sector cooperativoy como precedente ante eventuales cambios legales y profesionales.
Investigación: Comentarios sobre los nuevos códigos comentados o la increíble historia del indispensable libro borrador
Authors: Hauque Sergio Miguel
Published: October 2016

La introducción del nuevo Código Civil y Comercial (Ley 26994) en el derechoargentino ha producido modificaciones significativas en el plexo normativoque rige el accionar diario de los profesionales en Ciencias Económicas. Enparticular, son destacables las modificaciones en las normas legales generalesque se refieren a la contabilidad de las personas humanas y jurídicasque se habían mantenido casi inmutables por más de cincuenta años.Así las cosas, nos enfocamos en este trabajo en el análisis crítico dela visión doctrinaria de dos de los códigos comentados más significativos,en relación con los artículos 320, 321 y 322 del Código Civil y Comercialde la Nación.El principal objetivo de este trabajo es empezar a concientizar sobre laimportancia de la doctrina representada en los nuevos Códigos comentadosen referencia con la Contabilidad. La discusión sobre si el mantenimiento deregistros contables regulares será considerado una obligación o no, de pocoso de muchos sujetos, ya se ha iniciado y marcará en nuestra opinión la laborde los contadores públicos y abogados argentinos por muchas décadas.Parafraseando a Clemenceau, creemos que el alcance y contenido legalde la Contabilidad es un asunto demasiado serio para dejarlo sólo en manosdel Derecho. El caso del «indispensable libro borrador» sirve como ejemplode las consecuencias que pueden tener los análisis unidimensionales. La posible solución a estos problemas está en el trabajo conjunto entrelos especialistas del Derecho y de la Contabilidad, desde el primer día devigencia del Código, todos los días.
Investigación: Desarrollo endógeno y descentralización efectiva: una nueva revalorización del territorio desde la perspectiva boiseriana
Authors: Orozco Plascencia José Manuel
Published: October 2016

Estudiar y revisar la obra de Sergio Boisier Etcheverry (pensador latinoamericanodel territorio) reviste en una singular importancia teórica, enla que se rescatan más de 50 años de análisis del viejo y nuevo paradigmadel desarrollo regional. Dicho autor es capaz de crear una visiónpropia del desarrollo endógeno del espacio, con la cual busca alcanzaruna descentralización efectiva, a través de la interacción de sus actoresen tres escenarios: contextual, estratégico y político, los cuales convergenen lo que define como el hexágono del desarrollo regional, es decir con elgrado de conectividad o sinapsis que logran las instituciones, el entorno,los actores, recursos, cultura y procedimientos, cuando trabajan colectivamenteen la consolidación de tres tipos de regiones (pivótales, asociativasy virtuales). Boisier emula parte de sus aportaciones con la metáforadel vuelo de un cometa, donde el capital y la tecnología son la brisa quelo eleva, mientras que el cerebro y las manos son quienes lo construyen.En este artículo se estable como hipótesis que el pensamiento boiserianodel desarrollo regional es un instrumento adecuado para revalorar alterritorio integralmente, que considera la funcionalidad de la sociedad delconocimiento y de la construcción de una región inteligente para alcanzaruna descentralización efectiva. El escrito se divide en 6 secciones: motivacionespara estudiar las contribuciones de Boisier; revisión teórico–histórica del viejo paradigma del desarrollo regional; relación globalización–territorio; marco cognitivo para una descentralización efectiva; desarrolloendógeno; y la región y su vínculo con la sociedad del conocimiento.
English teaching in the elementary school: Some critical issues
Authors: Clavijo Amparo
Published: October 2016

Although for the last 10 years Colombia has proposed a National Plan for Bilingualism in different stages, the education of young children in Colombian public and private schools in relation to English language learning evidences some critical issues regarding the preparation of future teachers, the professional development of in-service teachers, and the nationalstandards for foreign language teaching.
SOBRE INVENCIONES Y TRUCULENCIAS
Authors: Méndez Rafael
Published: October 2016

Es muy probable que, antes que la experiencia misma de la vida, lo que nos constituye y nos otorga sentido, sea la versión que podamos construir a partir de esa experiencia. Su memoria. Pero esa construcción no se da, bajo ninguna circunstancia, de manera natural o desinteresada. Todo lo contrario, el territorio que ocupa es básicamente conflictivo, hecho de pura tensión, de forcejeos sin tregua al final de los cuales se resuelve una imposición: alguien, algunos, consiguen obligar a los demás a reconocer su versión, como la versión de todos, lo que implica, en definitiva, olvidar su artificialidad básica, pasar por alto su naturaleza arbitraria y por lo tanto, perfeccionar, de manera casi siempre tácita y silenciosa, su naturalización. Así las cosas, y en consecuencia de tamaña truculencia, los hechos y las experiencias que constituyen nuestro día a día, se nos dan de una manera que podríamos calificar de incontestable.Están ahí: ocupan su momento y su lugar, despliegan sus circunstancias. Su contundencia es tal, que el armazón entero de eso que llamamos realidad, construye sobre el poder de esa evidencia el conjunto pleno de sus estrategias y complejidades. Confianza descomunal, pues esa realidad, tan airosa y, en tantas oportunidades, tan arrogante, termina constituyéndose en mundo. En nuestro mundo. El único que, aparentemente, nos corresponde y que se nos impone en la “verdad” de la experiencia y de la memoria.
Optimal Functional Inequalities for Fractional Operators on the Sphere and Applications
Authors: Dolbeault Jean , Zhang An
Published: October 2016

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⁢

ℒ
s

⁢

F

⁢

𝑑
μ

 

for all
⁢
F

∈

H

s
/
2

⁢

(

𝕊
n

)

,

$\frac{\lVert F\rVert_{\mathrm{L}^{q}({\mathbb{S}}^{n})}^{2}-\lVert F\rVert_{% \mathrm{L}^{2}({\mathbb{S}}^{n})}^{2}}{q-2}\leq\mathsf{C}_{q,s}\int_{{\mathbb{% S}}^{n}}{F\mathcal{L}_{s}F}\,d\mu\quad\text{for all }F\in\mathrm{H}^{s/2}({% \mathbb{S}}^{n}),$

where

ℒ
s

${\mathcal{L}_{s}}$

denotes a fractional Laplace operator of order

s
∈

(
0
,
n
)

${s\in(0,n)}$

,

q
∈

[
1
,
2
)

∪

(
2
,

q
⋆

]

${q\in[1,2)\cup(2,q_{\star}]}$

,

q
⋆

=

2
⁢
n

n
-
s

${q_{\star}=\frac{2n}{n-s}}$

is a critical exponent, and

d
⁢
μ

${d\mu}$

is the uniform probability measure on

𝕊
n

${{\mathbb{S}}^{n}}$

. These inequalities are established with optimal constants using spectral properties of fractional operators. Their consequences for fractional heat flows are considered. If

q
>
2

${q>2}$

, these inequalities interpolate between fractional Sobolev and subcritical fractional logarithmic Sobolev inequalities, which correspond to the limit case as

q
→
2

${q\to 2}$

. For

q
<
2

${q<2}$

, the inequalities interpolate between fractional logarithmic Sobolev and fractional Poincaré inequalities. In the subcritical range

q
<

q
⋆

${q<q_{\star}}$

, the method also provides us with remainder terms which can be considered as an improved version of the optimal inequalities. The case

s
∈

(

-
n

,
0
)

${s\in(-n,0)}$

is also considered. Finally, weighted inequalities involving the fractional Laplacian are obtained in the Euclidean space, by using the stereographic projection.
Technikvermittlung als Anforderung in der Dienstleistungsinteraktion
Authors: Hielscher Volker , Nock Lukas , Kirchen-Peters Sabine
Published: October 2016

Der vorliegende Beitrag behandelt am empirischen Beispiel der Altenpflege den Einsatz von Technik im Kontext sozialer Dienstleistungsarbeit. Als entscheidender Faktor für die Integration von Technik in den Dienst-leistungsprozess wird die Technikvermittlung als von den Dienstleistungsakteuren in der Pflegeinteraktion zu erbringende Leistung herausgearbeitet. Bei der Technikvermittlung werden die Medien der Interaktionsarbeit (Kooperations-, Gefühls- und Emotionsarbeit, subjektivierendes Arbeitshandeln) darauf verwendet, die personalen Voraussetzungen zu schaffen, um Technikanwendung und Dienstleistungsinteraktion zeitlich und räumlich komplementär ineinander laufen zu lassen. Insofern handelt es sich bei der Technikvermittlung um eine funktionale Erweiterung von Interaktionsarbeit.
If Emotional Labor meets Micropolitics
Authors: Mucha Anna
Published: October 2016

Im Zuge der zunehmenden Subjektivierung in der Arbeitswelt nehmen auch die Anforderungen an Beschaffenheit und Darstellung von Emotionen ständig zu. Aus der ‚Disziplin des Handelns‘ wird eine ‚Disziplin des Seins‘ – die Folgen für die Beschäftigten sind emotionale Dissonanz und Erschöpfung. Vor diesem Hintergrund verknüpfe ich die Konzepte Emotionsarbeit und Mikropolitik und schlage ‚strategisches Surface Acting‘ als Bewältigungsstrategie beim Spagat zwischen Gefühlsnormen und Selbstfürsorge vor.
Travel intention: Relative value of transport alternatives
Authors: Brechan Inge
Published: October 2016

The objective was to test the Theory of Planned Behavior and the proposition that relative measures should be used in travel mode choice situations. Data from a survey in Norway was analyzed using regression analysis. The results indicated that factors of the Theory of Planned Behavior and past behavior predicted intentions to travel by car, public, transport, bicycle, and on foot. The results supported the idea that there is a split in perceived behavioral control in controllability and self-efficacy, as controllability was a significant predictor only for intention to travel by car. The use of relative measures added to the predictive strength of all predictors and increased prediction of behavioral intention for all travel modes. The results supported the Theory of Planned Behavior and the proposition regarding choice situations. Previous tests of the theory may have underestimated its predictive power. Attitudes, subjective norms, and perceived behavioral control predict travel intentions and may be targeted in interventions aimed at promoting travel mode choice.
The possibility of applying Whitehead’s philosophy
Authors: Zolcer Štefan
Published: October 2016

In this paper I try to elucidate the differences between theoretical and practical endeavors in philosophy, and then to show that in a sense philosophy has to be theoretical, but— if it claims to be viable—it must be practical as well. First I consider the meaning of the terms theoretical, practical, abstract, and concrete. Then, with the help of Whitehead’s ideas on this topic, I briefly reflect on the method, aims and role of philosophy. I hold that a properly established philosophical approach should have its roots in concrete experience and should include concrete applications. Thus, abstract ideas can be (and indeed often are) transformed into our daily life practices, being applied to solve real problems—personal, social, environmental, etc. The ideas are conveyed from the sphere of philosophy to that of ordinary life. In the next stage I demonstrate this principle using a concrete example, Whitehead’s philosophical system and how it can be fruitfully applied to the sphere of deep ecology. There are many other examples that could be mentioned, but giving a proper demonstration of this application principle requires more space and so I concentrate only on one of these examples.
Gesellschaftliche Moderne und ästhetische Moderne
Authors: Reckwitz Andreas
Published: October 2016

This paper argues that, from a sociological point of view, aesthetic modernity and social modernity are neither autonomous nor opposed structures. On the contrary, one encounters a simultaneous autonomization and shifting of borders within the aesthetic sphere, both of which originate in art and aesthetic movements. This framework is also the basis that gives shape to the modern aesthetic subject. From our - late modern - point of view, the aestheticization of the social sphere appears as a central structural feature of social modernity.
Der Zuschauer 1821/22, sein „alter würdiger Ahnherr“ und die Vettern: Blick aus Des Vetters Eckfenster auf Moralische Wochenschrift und Zeitblatt
Authors: Kaminski Nicola
Published: October 2016

Der vorliegende Beitrag sucht eine Blickkorrektur anzustoßen. Er zielt auf eine Lektüre von
„wort um wort, begriff um begriff“ Weibliches Schreiben als Praxis der Veränderung
Authors: Schulz Kristina
Published: October 2016

The article talks about Verena Stefan’s
‚… das Gefühl wirklichen Lebendigseins und dauernder Zufriedenheit …‘
Authors: Schramm Moritz
Published: October 2016

Contrary to the widespread opinion that Franz Kafka’s works mainly articulate the disturbance of all meaning and thus represent the deconstruction of every stable identity, this article focuses on the struggle for recognition in his diaries, letters and fragments. The article especially emphasizes the utopian ideas of recognition and the concept of positive selfhood, as it appears in Kafka’s works. Some comments on the story A Starvation Artist (1922) are included.
Wie kann man Geschichte der Germanistik nach 1945 schreiben?
Authors: Lepper Marcel
Published: October 2016

This article outlines four ways of writing the history of German Studies after 1945: 1. the history of theory and methods, 2. the history of projects and objects, 3. the history of institutions, 4. the biographical approach. The discipline is learning how to appreciate polycentric structures and philological traditions which transcend the boundaries of the 19th century and the nation state.
Protosoziologie: Stendhals Interaktionismus und die agonale Konzeption der Geselligkeit
Authors: Meyer Ingo
Published: October 2016

Sociology of literature has not yet established itself as a successful field of study. While sociological outlines suffer from a too generalist-oriented approach, philological attempts mostly illustrate their results with knowledge drawn from the social sciences. Focusing on the way Stendhal’s literary heroes act, this essay reveals his texts to be sociological commentaries located between the negative anthropology of the Baroque Era and Erving Goffman’s Interaction Theory. Thus, marked by the topic of socializing, Stendhal’s œuvre introduces the concept of society as a battlefield, which was nearly unknown in the discourse of 19th century Germany.
Das Jahr 1913 in Geschichte und Gegenwart
Authors: Hübinger Gangolf
Published: October 2016

While the year 1913, seen from a modern point of view, is considered a monument to the literary and artistic avant-garde, it was in fact primarily a year when knowledge of the human experience was reordered and was considered by intellectual contemporaries as the ‘Age of Compilations’. In this introduction to the topic both perspectives on the year 1913 are compared. At the same time, ‘Syncronoptic Historiography’s’ claim of establishing a new link between literature and history is scrutinized.
„Es ist immer nur ein wenig, was der Welt zur Erlösung fehlt“
Authors: Beßlich Barbara
Published: October 2016

Carl Sternheim’s drama
Das Jahrhundert der Presse und der Literatur in Frankreich
Authors: Jurt Joseph
Published: October 2016

In classical history of literature, authors have preferred the book above other written media. In France, however, from the beginning of the 19th century, the press experienced an immense revival, which had a far-reaching impact on literature. Literary style colored the press, while the journalistic matrix influenced literary productions, even producing new genres, such as the serial novel. Through their involvement with the press, writers achieved an effect on public opinion. At the same time, reflections emerged on the gain (or loss) of autonomy caused by this cooperation. For a decade, now, French cultural and literary studies have analysed this cooperation and thus established a new area of research.
Netzwerktheorie und Aufklärungsforschung
Authors: Ghanbari Nacim
Published: October 2016

This essay proposes a new appraisal of eighteenth century patronage culture. To this end, findings regarding network theory arrived at in the framework of research on the Enlightenment are extremely valuable. The discussion’s starting point is a reading of Friedrich Nicolai’s novel
Vienna 1913: Dans le vrai
Authors: Dowden Stephen D.
Published: October 2016

Absorbed in living, 1913 Vienna did not see the First World War coming and could not have. Vienna was a world experimenting with competing concepts of truth, but not of foretelling the future. One model emphasizes the inward, hidden character of truth, as in psychoanalysis. The other emphasizes the outward even superficial nature of truth.
How to improve information extraction from German medical records
Authors: Starlinger Johannes , Kittner Madeleine , Blankenstein Oliver , Leser Ulf
Published: October 2016

Vast amounts of medical information are still recorded as unstructured text. The knowledge contained in this textual data
has a great potential to improve clinical routine care, to support clinical research, and to advance personalization of
medicine. To access this knowledge, the underlying data has to be semantically integrated – an essential prerequisite to
which is information extraction from clinical documents.

A body of work, and a good selection of openly available tools for information extraction and semantic integration in the
medical domain exist, yet almost exclusively for English language documents. For German texts the situation is rather
different: research work is sparse, tools are proprietary or unpublished, and rarely any freely available textual
resources exist. In this survey, we (1) describe the challenges of information extraction from German medical documents
and the hurdles posed to research in this area, (2) especially address the problems of missing German language resources
and privacy implications, and (3) identify the steps necessary to overcome these hurdles and fuel research in semantic
integration of textual clinical data.
Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents
Authors: Can Ummugulsum , Buyukinan Muammer , Guzelant Asuman , Ugur Ayse , Karaibrahimoglu Adnan , Yabancıun Sukrıye
Published: October 2016

Background:

Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), α

Methods:

This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70±1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, α

Results:

Serum Hp, fetuin-A (p<0.01) and PF-4, hs-CRP, SAP, AGP (p<0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum α

Conclusions:

This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.
Underlying causes of neonatal deaths in term singleton pregnancies: home births versus hospital births in the United States
Authors: Grünebaum Amos , McCullough Laurence B. , Arabin Birgit , Dudenhausen Joachim , Orosz Brooke , Chervenak Frank A.
Published: October 2016

Introduction:

The objective of this study was to evaluate the underlying causes of neonatal mortality (NNM) in midwife-attended home births and compare them to hospital births attended by a midwife or a physician in the United States (US).

Methods:

A retrospective cohort study of the Centers for Disease Control (CDC) linked birth/infant death data set (linked files) for 2008 through 2012 of singleton, term (≥37 weeks) births and normal newborn weights (≥2500 grams).

Results:

Midwife-attended home births had the highest rate of neonatal deaths [122/95,657 neonatal mortality (NNM) 12.75/10,000; relative risk (RR): 3.6, 95% confidence interval (CI) 3–4.4], followed by hospital physician births (8695/14,447,355 NNM 6.02/10,000; RR: 1.7 95% CI 1.6–1.9) and hospital midwife births (480/1,363,199 NNM 3.52/10,000 RR: 1). Among midwife-assisted home births, underlying causes attributed to labor and delivery caused 39.3% (48/122) of neonatal deaths (RR: 13.4; 95% CI 9–19.9) followed by 29.5% due to congenital anomalies (RR: 2.5; 95% CI 1.8–3.6), and 12.3% due to infections (RR: 4.5; 95% CI 2.5–8.1).

Comment:

There are significantly increased risks of neonatal deaths among midwife-attended home births associated with three underlying causes: labor and delivery issues, infections, and fetal malformations. This analysis of the causes of neonatal death in planned home birth shows that it is consistently riskier for newborns to deliver at home than at the hospital. Physicians, midwives, and other health care providers have a professional responsibility to share information about the clinical benefits and risks of clinical management.