bluuebunny/crossref_metadata_2025 huggingface dataset:
Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment
Authors: Aust Anne-Christine , Vidova Veronika , Coufalikova Katerina , Smetanova Sona , Kozeluhova Kristyna , Micenkova Lenka , Videnska Petra , Smatana Stanislav , Budinska Eva , Borek Ivo , Janku Petr , Klanova Jana , Spacil Zdenek , Thon Vojtech
Published: November 2024

In the first days of life, the newborns’ intestinal microbiota develops simultaneously with the intestinal gut barrier and follows intestinal immunity. The mode of delivery shows significant impact on microbial development and, thus, the initiation of the tryptophan catabolism pathway. Further antibiotics (ATB) treatment of mothers before or during delivery affects the microbial and tryptophan metabolite composition of stool of the caesarean- and vaginal-delivered newborns. The determination of microbiome and levels of tryptophan microbial metabolites in meconium and stool can characterize intestinal colonization of a newborn. From 134 samples from the Central European Longitudinal Studies of Parents and Children: The Next Generation (CELSPAC: TNG) cohort study, 16S rRNA gene sequencing was performed, and microbial tryptophan metabolites were quantified using ultra-high-performance liquid chromatography with triple-quadrupole mass spectrometry. Microbial diversity and concentrations of tryptophan metabolites were significantly higher in stool compared to meconium. Treatment of mothers with ATB before or during delivery affects metabolite composition and microbial diversity in stool of vaginal- and caesarean-delivered newborns. Correlation of microbial and metabolite composition shows significant positive correlations of indol-3-lactic acid, N-acetyl-tryptophan and indol-3-acetic acid with Bifidobacterium, Bacteroides and Peptoclostridium. The positive effect of vaginal delivery on newborns’ microbiome development is degraded when mother is treated with ATB before or during delivery.

Key points

• Antibiotic treatment diminishes the positive effects of vaginal delivery.

• Antibiotic treatment affects metabolite and microbial composition in newborns.

• Bifidobacterium and Peptoclostridium could be the producer of indole-lactic acid.
Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity
Authors: Ohtani Tomoko , Kuroda Shinji , Kanaya Nobuhiko , Kakiuchi Yoshihiko , Kumon Kento , Hashimoto Masashi , Yagi Chiaki , Sugimoto Ryoma , Kikuchi Satoru , Kagawa Shunsuke , Tazawa Hiroshi , Urata Yasuo , Fujiwara Toshiyoshi
Published: November 2024

Dendritic cells (DCs) are crucial in cancer immunity, because they activate cytotoxic T cells by presenting tumor antigens. Recently, oncolytic virus therapy has been recognized as a systemic immune stimulator. We previously developed a telomerase-specific oncolytic adenovirus (OBP-301) and a p53-armed OBP-301 (OBP-702), demonstrating that these viruses strongly activate systemic antitumor immunity. However, their effects on DCs remained unclear. In the present study, the aim was to elucidate the mechanisms of DC activation by OBP-702, focusing particularly on tumor-derived exosomes. Exosomes (Exo53, Exo301, or Exo702) were isolated from conditioned media of human or murine pancreatic cancer cell lines (Panc-1, MiaPaCa-2, and PAN02) after treatment with Ad-p53, OBP-301, or OBP-702. Exo702 derived from Panc-1 and MiaPaCa-2 cells significantly upregulated CD86, CD80, CD83 (markers of DC maturation), and IFN-γ in DCs in vitro. Similarly, Exo702 derived from PAN02 cells upregulated CD86 and IFN-γ in bone marrow-derived DCs in a bilateral PAN02 subcutaneous tumor model. This DC maturation was inhibited by GW4869, an inhibitor of exosome release, and anti-CD63, an antibody targeting the exosome marker. Intratumoral injection of OBP-702 into PAN02 subcutaneous tumors significantly increased the presence of mature DCs and CD8-positive T cells in draining lymph nodes, leading to long-lasting antitumor effects through the durable activation of systemic antitumor immunity. In conclusion, tumor-derived exosomes play a significant role in DC maturation following OBP-702 treatment and are critical for the systemic activation of antitumor immunity, leading to the abscopal effect.
Imaging of peritoneal metastases of ovarian and colorectal cancer: joint recommendations of ESGAR, ESUR, PSOGI, and EANM
Authors: Vandecaveye Vincent , Rousset Pascal , Nougaret Stephanie , Stepanyan Artem , Otero-Garcia Milagros , Nikolić Olivera , Hameed Maira , Goffin Karolien , de Hingh Ignace H. J. , Lahaye Max J. ,   for the European Society of Gastrointestinal and Abdominal Radiology (ESGAR),   European Society of Urogenital Radiology (ESUR),   Peritoneal Surface Oncology Group International (PSOGI), de Hingh Ignace H. J. ,   European Association of Nuclear Medicine (EANM)
Published: November 2024

Objectives

Diagnostic imaging of peritoneal metastases in ovarian and colorectal cancer remains pivotal in selecting the most appropriate treatment and balancing clinical benefit with treatment-related morbidity and mortality. To address the challenges related to diagnostic imaging and detecting and reporting peritoneal metastatic spread, a joint guideline was created by the European Society of Gastrointestinal and Abdominal Radiology (ESGAR), European Society of Urogenital Radiology (ESUR), Peritoneal Surface Oncology Group International (PSOGI), and European Association of Nuclear Medicine (EANM).

Methods

A targeted literature search was performed and consensus recommendations were proposed using Delphi questionnaires and a five-point Likert scale.

Results

A total of three Delphi rounds were performed. Consensus was reached on the position of diagnostic imaging for assessment of operability, treatment response monitoring, and follow-up of peritoneal metastases, optimal imaging modality and their technical imaging requirements depending on the indication and how to optimise communication of imaging results by the report and multidisciplinary board discussion. The complete list of recommendations is provided.

Conclusion

These expert consensus statements aim to guide appropriate indications, acquisition, interpretation, and reporting of imaging for operability assessment, treatment response monitoring, and follow-up of peritoneal metastases in ovarian and colorectal cancer patients.

Key Points

QuestionStaging peritoneal metastases (PM) helps to guide clinical decision-making for colorectal and ovarian cancer patients. How can we optimise the use of imaging techniques to assess PM?

FindingsImaging plays a crucial role in the detection, operability assessment, treatment response monitoring, and follow-up of peritoneal metastases in colorectal and ovarian cancer patients.

Clinical relevanceThese expert consensus statements aim to guide appropriate indication, acquisition, interpretation, and reporting of imaging for operability assessment, treatment response monitoring, and follow-up of peritoneal metastases in ovarian and colorectal cancer patients.
Psychological distress in adults after pediatric kidney replacement therapy
Authors: Laube Nora F. , Mader Luzius , Heinzelmann Marc-Andrea , Hunziker Sandra , Michel Gisela , Kuehni Claudia E. , Laube Guido F.
Published: November 2024

Background

There is limited information about psychological distress in adults who underwent kidney replacement therapy (KRT) during childhood. This study aimed to describe psychological distress in adults after KRT during childhood in comparison to the Swiss general population and to evaluate associations with sociodemographic and clinical characteristics.

Methods

We sent a questionnaire to 143 people from the Swiss Pediatric Renal Registry (SPRR), who were alive, over 18 years old, started KRT before the age of 18 years, and were German speakers. We measured psychological distress using the Brief Symptom Inventory 18 (BSI-18) and evaluated the Global Severity Index 18 (GSI-18), reflecting the overall level of distress, and the three subscales: depression, somatization, and anxiety. We compared levels of psychological distress to normal data from the Swiss general population and used regression models to identify associations with sociodemographic and clinical characteristics.

Results

Eighty persons with a mean age of 39 years (SD 10.1) responded to the questionnaire (response rate 56%). Overall, the GSI-18 and all subscales of the BSI-18 were similar. Unemployed participants (25%) reported higher levels of somatization and were more likely to experience psychological distress. Participants using psychotropic drugs (14%) reported higher levels of overall psychological distress (10%), depression (13%) and somatization (9%).

Conclusions

Adults after KRT during childhood showed good long-term psychological well-being. These results are encouraging and underline the favorable outcome of these patients. So besides the excellent somatic outcome, these patients can achieve a psychological healthy life after diagnosis of chronic kidney disease.

Graphical abstract
Re-examining the chatBot Usability Scale (BUS-11) to assess user experience with customer relationship management chatbots
Authors: Borsci Simone , Schmettow Martin
Published: November 2024

Intelligent systems, such as chatbots, are likely to strike new qualities of UX that are not covered by instruments validated for legacy human–computer interaction systems. A new validated tool to evaluate the interaction quality of chatbots is the chatBot Usability Scale (BUS) composed of 11 items in five subscales. The BUS-11 was developed mainly from a psychometric perspective, focusing on ranking people by their responses and also by comparing designs’ properties (designometric). In this article, 3186 observations (BUS-11) on 44 chatbots are used to re-evaluate the inventory looking at its factorial structure, and reliability from the psychometric and designometric perspectives. We were able to identify a simpler factor structure of the scale, as previously thought. With the new structure, the psychometric and the designometric perspectives coincide, with good to excellent reliability. Moreover, we provided standardized scores to interpret the outcomes of the scale. We conclude that BUS-11 is a reliable and universal scale, meaning that it can be used to rank people and designs, whatever the purpose of the research.
A nearly optimal randomized algorithm for explorable heap selection
Authors: Borst Sander , Dadush Daniel , Huiberts Sophie , Kashaev Danish
Published: November 2024

Explorable heap selection is the problem of selecting the nth smallest value in a binary heap. The key values can only be accessed by traversing through the underlying infinite binary tree, and the complexity of the algorithm is measured by the total distance traveled in the tree (each edge has unit cost). This problem was originally proposed as a model to study search strategies for the branch-and-bound algorithm with storage restrictions by Karp, Saks and Widgerson (FOCS ’86), who gave deterministic and randomized

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Impact of field drying at different initial leaf ages on growth and yield formation of direct seeding rice in Chengdu plain
Authors: Ouyang Yuyuan , Zhu Conghua , Li Wei , Yu Junqi , Luo Xi , Li Xuyi
Published: November 2024

To determine the optimal drying period for direct seeding rice, we conducted experiments using two rice cultivars: hybrid indica (Shuyou 217) and conventional indica (Huang Huazhan). The experiments explored the influence of varying initial leaf development stages on tillering dynamics, leaf area, dry matter production, yield, and yield components in direct seeding rice. The results indicated a significant correlation between the initial leaf development stage and the yield of direct seeding rice. As the initial leaf development stage progressed, the number of effective panicles increased, while key traits affecting panicle yield, such as grain/spikelet? Number per panicle, seed setting rate, and 1000-grain weight, decreased. Additionally, varietal differences in tillering reduction were observed across different leaf development stages. Shuyou 217 exhibited a decrease in heading rate with increasing leaf development stage, whereas Huang Huazhan showed no significant difference. With delayed seeding planting age, both cultivars demonstrated an increasing trend in the leaf area index, initially leading to a rise in effective leaf area proportion, followed by a decline. At the full heading and maturity stages, the dry weight of the stem sheath and panicles per plant decreased as the leaf development stage was delayed. However, the output and transport rates of stem sheath assimilated first increased and then decreased. From a practical perspective, field drying management should be aligned with varietal characteristics to reduce ineffective tillering, ensure sufficient dry matter accumulation during the full heading stage, and optimize post-heading dry matter export and transport. This strategy promotes the coordination between the “source” and “sink” dynamics in rice, ultimately maximizing yield in direct-seeded rice systems.
The 3rd Hutchinson lecture: numerical modelling of forests with uprooting as a nature-based solution to mitigate flow-type landslides
Authors: Choi C. E.
Published: November 2024

To protect human lives and infrastructure in mountainous regions from flow-type landslides, engineered countermeasures, such as rigid and flexible barriers, are installed along predicted flow paths. Over recent years, research efforts in physical and numerical modelling have helped advance the understanding of impact mechanisms involved and enabled the optimization of the design of engineered solutions. With the advent of sustainable engineering, attention has shifted towards the use and development of nature-based solutions to impede flow-type landslides. A simple nature-based solution is to consider the effects of forests on the mobility of flow-type landslides. However, to leverage forests, the complex flow-stem interactions and effects of uprooting need to be captured. In this paper, details and results of a new GPU-empowered MPM-LSDEM numerical solver that simulates the effects of flows through tree stems that can uproot are presented along with systematic evaluation of the solver. Simulations of flow-forest interaction with and without uprooting show that forests have profound effects on flow forest interaction. For dense forests, uprooted stems can push flow material to enhance its runout distance. Additionally, uprooted stems tend to concentrate near the front of the flows even if they were evenly distributed throughout the model forest at the beginning. The impact force exerted by a stem can be considered concentrated loading and can damage barriers along the flow path. Taken together, hazard assessment tools that can model the effects of uprooting are crucial to close predictions of hazard extent (i.e., runout distance) and the design of physical countermeasures such as barriers.
First-year real-world experience of intravitreal brolucizumab injection for refractory neovascular age-related macular degeneration
Authors: Lee Jeong Hyun , Shin Joo Young , Ahn Jeeyun
Published: November 2024

Purpose

To investigate the first-year real-world anatomical and functional outcomes of intravitreal brolucizumab injection in eyes with refractory neovascular age-related macular degeneration (nAMD).

Study design

Retrospective observational study.

Methods

nAMD patients who showed poor response to previous anti-vascular endothelial growth factor (VEGF) agents were switched to brolucizumab. Functional and anatomical outcomes were evaluated at initial treatment of nAMD, after treatment with other anti-VEGF agents and after switching and treating with brolucizumab for 1 year. Safety profile was also evaluated after brolucizumab injection. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), and the presence of fluid in different compartments (intraretinal fluid [IRF], subretinal fluid [SRF], pigment epithelial detachment [PED]) were assessed at each time point.

Results

A total of 40 eyes of 40 patients were included in the study. BCVA remained unchanged throughout treatment (p > 0.05). CFT did not change after treatment with other anti-VEGF agents (p = 0.588) but decreased after switching to brolucizumab (p < 0.001). SFCT decreased after treatment with other anti-VEGF agents (p = 0.025) but not after switching to brolucizumab (p = 0.236). Presence of SRF (p = 0.001) and PED (p = 0.001) decreased significantly after switching to brolucizumab, despite their persistence with prior treatments using other anti-VEGF agents. However, IRF persisted even after switching to brolucizumab (p = 0.745). Intraocular inflammation (IOI)-related adverse events were reported in 3 eyes (7.14%).

Conclusion

Analysis of first-year real-world outcomes after switching to brolucizumab in nAMD patients refractory to other anti-VEGF agents showed improved anatomic outcomes, limited functional improvement and low incidence of IOI-related adverse events.
Utility of under-sampled scans with iterative reconstruction and high-frequency preserving transform for high spatial resolution magnetic resonance cholangiopancreatography
Authors: Kondo Shota , Nakamura Yuko , Higaki Toru , Nishihara Takashi , Takizawa Masahiro , Shirai Toru , Fujimori Motoshi , Bito Yoshitaka , Narita Keigo , Fonseca Dara , Maeda Shogo , Kawashita Ikuo , Honda Yukiko , Awai Kazuo
Published: November 2024

Purpose

Under-sampled scans with iterative reconstruction and high-frequency preserving transform (Us-IRHF) can increase the acquisition speed without degrading the image quality by recovering image information from under-sampled data. We investigate the clinical applicability of high spatial resolution magnetic resonance cholangiopancreatography (MRCP) images without extending the scanning time using Us-IRHF.

Methods

A slit phantom was scanned with conventional- (without Us-IRHF), Us-IR- (without HF), and Us-IRHF scanning. The matrix size was 320 × 320 for Us-IR- and Us-IRHF- and 288 × 208 for conventional scanning. Modulation transfer function (MTF) focused on the 1.0 lp/cm gauge for each scanning was calculated. For clinical study we acquired respiratory-triggered 3D MRCP scans with and without Us-IRHF (U+-, U−MRCP) in 41 patients. The matrix size was 320 × 320 for U+- and 288 × 208 for U−MRCP. The acquisition time and the relative duct-to-periductal contrast ratios (RCs) for the right- and left intrahepatic bile-, the common bile-, and the main pancreatic duct were recorded. Visualization of each duct and overall image quality was scored on 5-point confidence scales. For visualization of each duct the score ranged from 1 (not visible) to 5 (visible with excellent details), for the image quality, it ranged from 1 (undiagnostic) to 5 (excellent). Superiority for the qualitative visualization score and non-inferiority for the RC values with prespecified margins were assessed.

Results

Phantom study showed that compared to the conventional- and Us-IR (without HF) images, the MTF for the Us-IRHF image revealed the highest response. For clinical study, the mean acquisition time was 161 s for U+- and 165 s for U−MRCP. For all ducts, the RC value of U+MRCP was non-inferior to U−MRCP and the qualitative visualization score assigned to U+MRCP was superior to U−MRCP.

Conclusion

Us-IRHF improved the image quality of high spatial resolution MRCP without extending the scanning time.
Recycle right: How to decrease recycling contamination with informational point-of-disposal signage
Authors: Cakanlar Aylin , Hunter Megan , Nenkov Gergana Y.
Published: November 2024

Plastic pollution represents a grand challenge facing society, yet the amount of plastic being recycled is only about 5%. This recycling crisis has intensified with the growing problem of recycling contamination (i.e., incorrect placement of unrecyclable materials in recycling receptacles). This research investigates the potential for informational point-of-disposal recycling signage to decrease recycling contamination. In a longitudinal field study and three experiments, the authors demonstrate that providing schema-congruent prescriptive information (“Recycle these items”) does not reduce recycling contamination and may inadvertently lead to over-recycling. In contrast, the presence of proscriptive information that is moderately incongruent with established schemas (“Do not recycle these items”) prompts more effortful, piecemeal processing. This encourages individuals to integrate the information into their recycling decisions, diminishing their dependence on pre-existing beliefs and expectations regarding recycling and, consequently, lowering contamination rates. Recycling expertise is found to moderate the effects of point-of-disposal recycling signage. By examining such nuanced recycling communication strategies, this research aims to shift the conversation from “recycle more” to “recycle right.”
The Predictive Validity of the Full Outline of UnResponsiveness Score Compared to the Glasgow Coma Scale in the Intensive Care Unit: A Systematic Review
Authors: Schey Jaime E. , Schoch Monica , Kerr Debra
Published: November 2024

The Full Outline of UnResponsiveness (FOUR) score was developed to overcome the limitations of the Glasgow Coma Scale (GCS) when assessing individuals with impaired consciousness. We sought to review the evidence regarding the predictive validity of the GCS and FOUR score in intensive care unit (ICU) settings. This review was prospectively registered in PROSPERO (CRD42023420528). Systematic searches of CINAHL, MEDLINE, and Embase were undertaken. Prospective observational studies were included if both GCS and FOUR score were assessed in adults during ICU admission and if mortality and/or validated functional outcome measure scores were collected. Studies were excluded if they exclusively investigated patients with traumatic brain injury. Screening, data extraction, and quality assessment using the Quality in Prognosis Studies tool were conducted by two reviewers. Twenty studies of poor to moderate quality were included. Many studies only included patients with neurological illness and excluded sedated patients, despite high proportions of intubated patients. The FOUR score achieved higher area under the receiver operating characteristic curve values for mortality prediction compared with the GCS, and the FOUR score achieved significantly higher area under the receiver operating characteristic curve values for predictions of ICU mortality. Both coma scales showed similar accuracy in predicting “unfavorable” functional outcome. The FOUR score appeared to be more responsive than the GCS in the ICU, as most patients with a GCS score of 3 obtained FOUR scores between 1 and 8 due to preserved brainstem function. The FOUR score may be superior to the GCS for predicting mortality in ICU settings. Further adequately powered studies with clear, reliable methods for assessment of index and outcome scores are required to clarify the predictive performance of both coma scales in ICUs. Inclusion of sedated patients may improve generalizability of findings in general ICU populations.
Expansion of stereotactic work envelope using transformation matrices and geometric algebra for neurosurgery
Authors: Sharaf Basel , Lewis Seth , Choung David , Goyal Abhinav , Scheitler Kristen M. , Hong Lydia S. , Blaha Charles D. , Hanna Barbara , Chang Kyungwon , Yuen Jason , Oh Yoonbae , Shin Hojin , Grewal Sanjeet , Chang Jin Woo , Miller Kai , Lee Kendall H.
Published: November 2024

Stereotactic systems have traditionally used Cartesian coordinate combined with linear algebraic mathematical models to navigate the brain. Previously, the development of a novel stereotactic system allowed for improved patient comfort, reduced size, and carried through a simplified interface for surgeons. The system was designed with a work envelope and trajectory range optimized for deep brain stimulation applications only. However, it could be applied in multiple realms of neurosurgery by spanning the entire brain. To this end, a system of translational and rotational adapters was developed to allow total brain navigation capabilities. Adapters were designed to fit onto a Skull Anchor Key of a stereotactic frame system to allow for rotation and translation of the work envelope. Mathematical formulas for the rotations and translations associated with each adapter were developed. Mechanical and image-guided accuracies were examined using a ground truth imaging phantom. The system’s clinical workflow and its ability to reliably and accurately be used in a surgical scenario were investigated using a cadaver head and computed tomography guidance. Eight adapters designed and 3D-printed allowed the work envelope to be expanded to the entire head. The mechanical error was 1.75 ± 0.09 mm (n = 20 targets), and the cadaver surgical targeting error was 1.18 ± 0.28 mm (n = 10 implantations). The novel application of conventional and geometric algebra in conjunction with hardware modifications significantly expands the work envelope of the stereotactic system to the entire cranial cavity. This approach greatly extends the clinical applications by the system.
Laser-Induced Highly Stable Conductive Hydrogels for Robust Bioelectronics
Authors: Li Yibo , Zhou Hao , Yang Huayong , Xu Kaichen
Published: November 2024

Despite the promising progress in conductive hydrogels made with pure conducting polymer, great challenges remain in the interface adhesion and robustness in long-term monitoring. To address these challenges, Prof. Seung Hwan Ko and Taek-Soo Kim’s team introduced a laser-induced phase separation and adhesion method for fabricating conductive hydrogels consisting of pure poly(3,4-ethylenedioxythiophene):polystyrene sulfonate on polymer substrates. The laser-induced phase separation and adhesion treated conducting polymers can be selectively transformed into conductive hydrogels that exhibit wet conductivities of 101.4 S cm−1 with a spatial resolution down to 5 μm. Moreover, they maintain impedance and charge-storage capacity even after 1 h of sonication. The micropatterned electrode arrays demonstrate their potential in long-term in vivo signal recordings, highlighting their promising role in the field of bioelectronics.

Graphical Abstract
Wafer-Scale Vertical 1D GaN Nanorods/2D MoS2/PEDOT:PSS for Piezophototronic Effect-Enhanced Self-Powered Flexible Photodetectors
Authors: Tang Xin , Jiang Hongsheng , Lin Zhengliang , Wang Xuan , Wang Wenliang , Li Guoqiang
Published: November 2024

van der Waals (vdW) heterostructures constructed by low-dimensional (0D, 1D, and 2D) materials are emerging as one of the most appealing systems in next-generation flexible photodetection. Currently, hand-stacked vdW-type photodetectors are not compatible with large-area-array fabrication and show unimpressive performance in self-powered mode. Herein, vertical 1D GaN nanorods arrays (NRAs)/2D MoS2/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays firstly. The as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W−1 and a high detectivity of 1.2 × 1011 Jones, as well as a fast response speed of 54/71 µs, thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II heterojunction. Notably, the strain-tunable photodetection performances of device have been demonstrated. Impressively, the device at − 0.78% strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W−1, a detectivity of 2.6 × 1011 Jones, and response times of 40/45 µs, which are superior to the state-of-the-art self-powered flexible photodetectors. This work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection, which performs well in flexible sensors.
Effect of abamectin on haemolymph and ovarian proteins during the reproductive cycle of female Argas (Persicargas) arboreus (Acari: Argasidae)
Authors: Abotaleb Khairiyah Sayed , Shanbaky Nawal M. , Helmy Nadia , Yousery Ayat , AbdelHamid Amira E. , Ahmed Shimaa Salah
Published: November 2024

The avian tick Argas (Persicargas) arboreus is a vector of pathogens infecting the nestlings of the agriculturally beneficial bird, the buff-backed heron in Egypt. The topical treatment of the fed-mated (engorged) female A. (P.) arboreus with a sublethal dose of abamectin (10 µl 10 ppm/female) on the 3rd day after feeding (daf), reduced the concentration of total protein in the haemolymph (HL) by 13–66%, in the ovary by 30–54%, and in freshly deposited eggs by 11–16%, compared to untreated females during vitellogenesis and oviposition. However, the treatment did not prevent vitellogenesis and oviposition but reduced the number of mature oocytes (stages III–V) and deposited eggs. Additionally, it delayed the onset and slowed the progress of each process in the treated females. The application of abamectin at the onset of vitellogenesis (on the 3rd daf) in normal female and the prominent decrease inHL total protein concentration in treated female on the 4th daf pointed to a probable interference of abamectin with the release of the vitellogenesis-inducing factor (VIF) and/or other subsequent hormone(s) known to regulate vitellogenesis in this argasid tick species.

Graphical abstract
Infrared biospectroscopy as a rapid screening tool for COVID-19 diagnosis
Authors: López-Mendoza Carlos M. , Medellín-Castillo Nahúm A. , Mizaikoff Boris , Benitez-Arvizu Gamaliel , Krebs Patrick , Díaz de León-Martínez Lorena , Alcántara-Quintana Luz E.
Published: November 2024

Background

Advanced screening technologies, particularly biospectroscopic techniques like infrared attenuated total reflection (IR-ATR) spectroscopy, are gaining significance for their potential to offer fast, reliable, and specific diagnostic methods. These techniques, combined with chemometric approaches, have been increasingly applied for identifying bacterial and viral infections, cancer screening, and are now reported as useful in the context of COVID-19 and Long-COVID. The application IR-ATR, in point-of-care settings is crucial across various contexts. The ongoing progress in deploying IR-ATR in clinical settings represents a significant advancement in infectious disease screening.

Objective

The main objective of this study is to demonstrate the efficacy of IR-ATR as a rapid, sensitive, and specific tool for pathogen detection and infection monitoring at the clinical level, in agreement with existing literature.

Methods

The present study applied IR-ATR spectroscopy as a direct screening methodology that discriminates between patients infected with the SARS-CoV-2 virus and healthy subjects via dried serum samples.

Results

The chemometric analysis through PCA presented an accuracy of 99.18% with a sensitivity and specificity of 98.83% and 97.32% respectively.

Conclusions

This approach supports the potential of IR-ATR for pathogen detection -SARS-CoV-2- in clinical settings as a rapid, sensitive, specific and minimally invasive technique that could be valuable for the deployment of rapid platforms for pathogen identification and viral infection monitoring.
A Look Back on the History of Cerebral Revascularization for Acute Ischemic Stroke: A Neurosurgeon’s Perspective
Authors: Findlay Jay Max
Published: November 2024

This review looks back on our experience with acute middle cerebral artery embolectomies in the 1990s, frowned upon by stroke experts at the time, and no match for the newly introduced and proven treatment of acute ischemic stroke with intravenous recombinant tissue plasminogen activator (alteplase). The past several decades have seen dramatic developments in acute cerebral revascularization, the major paradigm shift being in the form of endovascular thrombectomy. Mechanical thrombectomy has moved from the operating room, where we performed it, to the interventional angiography suite armed with ever-improving clot aspiration and retrieval technologies.
The structure and dynamics of the laminar separation bubble
Authors: Eljack Eltayeb M.
Published: November 2024

A novel selective mode decomposition, proper orthogonal decomposition and dynamic mode decomposition methods are used to analyse large-eddy simulation data of the flow field about a NACA0012 airfoil at low Reynolds numbers of

$5\times 10^4$

and

$9\times 10^4$

, and at near-stall conditions. The objective of the analysis is to investigate the structure of the laminar separation bubble (LSB) and its associated low-frequency flow oscillation (LFO). It is shown that the flow field can be decomposed into three dominant flow modes: two low-frequency modes (LFO-Mode-1 and LFO-Mode-2) that govern an interplay of a triad of vortices and sustain the LFO phenomenon, and a high-frequency oscillating (HFO) mode featuring travelling Kelvin–Helmholtz waves along the wake of the airfoil. The structure and dynamics of the LSB depend on the energy content of these three dominant flow modes. At angles of attack lower than the stall angle of attack and above the angle of a full stall, the flow is dominated by the HFO mode. At angles of attack above the stall angle of attack the LFO-Mode-2 overtakes the HFO mode, triggers instability in the LSB and initiates the LFO phenomenon. Previous studies peg the structure, stability and bursting conditions of the separation bubble to local flow parameters. However, the amplitude of these local flow parameters is dependent on the energy content of the three dominant flow modes. Thus, the present work proposes a more robust bursting criterion that is based on global eigenmodes.
Self-supervised contrastive learning of radio data for source detection, classification and peculiar object discovery
Authors: Riggi S. , Cecconello T. , Palazzo S. , Hopkins A.M. , Gupta N. , Bordiu C. , Ingallinera A. , Buemi C. , Bufano F. , Cavallaro F. , Filipović M.D. , Leto P. , Loru S. , Ruggeri A.C. , Trigilio C. , Umana G. , Vitello F.
Published: November 2024

New advancements in radio data post-processing are underway within the Square Kilometre Array (SKA) precursor community, aiming to facilitate the extraction of scientific results from survey images through a semi-automated approach. Several of these developments leverage deep learning methodologies for diverse tasks, including source detection, object or morphology classification, and anomaly detection. Despite substantial progress, the full potential of these methods often remains untapped due to challenges associated with training large supervised models, particularly in the presence of small and class-unbalanced labelled datasets.

Self-supervised learning has recently established itself as a powerful methodology to deal with some of the aforementioned challenges, by directly learning a lower-dimensional representation from large samples of unlabelled data. The resulting model and data representation can then be used for data inspection and various downstream tasks if a small subset of labelled data is available.

In this work, we explored contrastive learning methods to learn suitable radio data representations by training the SimCLR model on large collections of unlabelled radio images taken from the ASKAP EMU and SARAO MeerKAT GPS surveys. The resulting models were fine-tuned over smaller labelled datasets, including annotated images from various radio surveys, and evaluated on radio source detection and classification tasks. Additionally, we employed the trained self-supervised models to extract features from radio images, which were used in an unsupervised search for objects with peculiar morphology in the ASKAP EMU pilot survey data. For all considered downstream tasks, we reported the model performance metrics and discussed the benefits brought by self-supervised pre-training, paving the way for building radio foundational models in the SKA era.
Comparative effects of tea and coffee drinking on body weight in adults: a systematic review and network meta-analysis of randomised trials
Authors: Jayedi Ahmad , Norouziasl Reyhane , Aletaha Azadeh , Mirrafiei Amin , Soltani Akbar , Shab-Bidar Sakineh
Published: November 2024

We aimed at quantifying the effects of different tea and coffee on weight loss in adults. We searched PubMed, Scopus, CENTRAL and grey literature sources to July 2024. The study excluded cross-over trials without washout period, those in critically ill patients, pregnant or breast-feeding women, multicomponent interventions and active control groups with tea or coffee. A random-effects network meta-analysis with a Bayesian framework was performed to calculate the mean difference (MD) and 95 % credible intervals (CrIs). The certainty of evidence was rated using the Grading of Recommendations Assessment, Development, and Evaluation approach, and risk of bias was assessed using Cochrane tool. Twenty-two randomised controlled trials with 1710 participants (average intervention duration = 10 weeks) were included. Green tea was effective for weight loss compared with placebo (MD: −1·23 kg, 95 % CrI: −2·45, −0·02; low certainty evidence) or water (MD: −1·61 kg, 95 % CrI: −2·90, −0·35; very low certainty evidence), while other beverages (coffee, decaffeinated coffee, green coffee, black tea and sour tea) were not. Green tea was effective for weight loss compared with water in sensitivity analysis of healthy individuals (MD: −3·31 kg, 95 % CrI: −5·83, −1·04). Based on very low to low certainty evidence, green tea drinking may result in a small weight loss in adults. This study mainly focused on weight loss effects of green tea and coffee, with limited data on other teas. Only five trials had longer intervention durations, suggesting future research on long-term effects. Most trials had high bias risk and low certainty, requiring more high-quality trials.
Drip irrigation and mulching reduce weed interference and improve water productivity of spring maize
Authors: Mohanpuria Ritu , Kaur Simerjeet , Singh K. B. , Brar A. S.
Published: November 2024

Drip irrigation and mulching were tested to minimize unproductive water loss through evaporation and weed interference. A field experiment was conducted during spring season of 2020 and 2021 in split plot design with three replications. The study includes six treatment combinations of drip irrigation methods (surface drip and subsurface drip irrigation) and mulching (black plastic, paddy straw and no mulch) along with one conventional furrow irrigation without mulching (as control) in main plots. Four weed control treatments (atrazine 1000 g a.i./ha as pre-emergence, two hand weedings at 30 and 60 days after sowing [DAS], weed free and weedy for whole crop growth period) were kept in the subplots. The combination of drip irrigation and mulches significantly enhanced leaf area index and crop biomass at 60 DAS than furrow irrigation. Integration of subsurface drip irrigation with plastic mulching resulted in the lowest weed density and biomass among main plots. Drip irrigation coupled with plastic and straw mulching resulted in 86 and 50% reduction in weed density and biomass, respectively, as compared to no mulching. Integration of subsurface drip with paddy straw mulch and black plastic mulch resulted in 17.1 and 15.5% higher maize grain yield, respectively, as compared to furrow irrigation. The highest irrigation water productivity (3.58 kg/m3) was observed in combination of subsurface drip and paddy straw mulch followed by combination of subsurface drip and black plastic mulch (3.51 kg/m3). Overall, straw mulching in drip irrigation system proved economical in terms of maize productivity.
Assessing the diversity of freshwater fish trematodes from Laguna Escondida, Los Tuxtlas tropical rainforest, Mexico, using morphology and 28S rDNA sequences as barcodes
Authors: Velázquez-Urrieta Y. , García-Varela M. , Pérez-Ponce de León G.
Published: November 2024

Despite a great effort made for almost 90 years, the diversity of freshwater fish trematodes in Mexico is still far from being fully known. The addition of molecular data to the description of trematode diversity in the last two decades added the potential to establish more robust species limits and a more accurate biodiversity estimation, but also led in some instances to the recognition of cryptic species complexes. Here, we used sequences of the large subunit of the nuclear ribosomal gene (28S rRNA) as barcodes, and morphological data, to assess the diversity of freshwater fish trematodes from a lake within a tropical rainforest. Eighty freshwater fish specimens of eight species were studied, and 120 trematode specimens were collected. Morphologically, specimens were allocated into nine genera; molecular phylogenetic analyses along with sequence divergence data provided evidence for recognising 11 trematode taxa, six adults and five metacercariae; six of them were identified to species level. Geographical distribution and host association patterns are briefly discussed for each trematode taxa.
First description of post-flexion larvae of the West Atlantic trumpetfish, Aulostomus maculatus
Authors: Sundin Josefin , Freese Marko , Otten Eric , Marohn Lasse , Blancke Tina , Hanel Reinhold
Published: November 2024

The West Atlantic trumpetfish Aulostomus maculatus is a species of little commercial importance, but it is frequently used as a study organism in behavioural ecology, and it has been traded in the aquarium industry to some extent. The adult life stage is well described, however its early life history is nearly unknown. This paper provides the first description of post-flexion larvae of A. maculatus, including detailed illustrations, photographs, morphological data, and collection site data of specimens collected during a multipurpose research survey conducted within the Sargasso Sea Subtropical Convergence Zone. The collection site also implies a geographic range expansion, off the continental shelf, of the pelagic larvae stage. This paper hence advances the scientific knowledge about the early life stages, distribution and ecology of this species.
Family income and polygenic scores are independently but not interactively associated with cognitive performance among youth genetically similar to European reference populations
Authors: Paul S.E. , Elsayed N.M. , Colbert S.M.C. , Bogdan R. , Hatoum A.S. , Barch D.M.
Published: November 2024

Cognitive abilities are heritable and influenced by socioeconomic status (SES). It is critical to understand the association between SES and cognition beyond genetic propensity to inform potential benefits of SES-based interventions and to determine if such associations vary across (i) cognitive domains, (ii) facets of SES, and/or (iii) genetic propensity for different aspects of cognition. We examined the contributions of neighborhood socioeconomic advantage, family income, and polygenic scores (PGS) for domains of cognition (i.e., general cognitive ability, executive function, learning and memory, fluid reasoning) in a sample of children (ages 9–10; n = 5549) most genetically similar to reference populations from Europe. With some variability across cognitive outcomes, family income and PGS were independently significantly associated with cognitive performance. Within-sibling analyses revealed that cognitive PGS associations were predominantly driven by between-family effects suggestive of non-direct genetic mechanisms. These findings provide evidence that SES and genetic propensity to cognition have unique associations with cognitive performance in middle childhood. These results underscore the importance of environmental factors and genetic influences in the development of cognitive abilities and caution against overinterpreting associations with PGS of cognitive and educational outcomes as predominantly direct genetic effects.
‘If You Love Music You Should Learn How to DJ’: Maria Chavez and Elijah interviewed by Jake Williams
Authors: Williams Jake
Published: November 2024

In this article, DJ and scholar Jake Williams speaks with Maria Chavez and Elijah about their ideas concerning education and pedagogy in electronic music. Although they come from very different musical backgrounds, the rationale for the joint interview was twofold: first, they are both DJs who think deeply about their practice and have strong pedagogical commitments; and second, their pedagogical practices have led to them to work between informal and formal educational spaces, across a range of age groups. The talk touches on their views on music education, academia, definitions of success, what it means to be ‘open source’ and, of course, DJing.
Exploring patient awareness of palliative care - optimal timing and preferred approaches
Authors: Trevizan Fulvio Bergamo , Paiva A Carlos Eduardo , de Almeida Laura Fiacadori , Zimmermann Camila , Bruera Eduardo , Paiva B Bianca Sakamoto Ribeiro
Published: November 2024

Objectives

To explore patients’ awareness levels of palliative care (PC) and how this awareness shapes their preferences regarding the timing and approach for discussing it.

Methods

The study, conducted at a prominent institution specializing in oncology care, enrolled women aged 18–75 years who had been diagnosed with breast cancer. Patients completed guiding questions: Do you know what PC is?, When is the most appropriate time and the most appropriate way to discuss PC?. The interviews were conducted exclusively via video call and were recorded, transcribed, and then deleted.

Results

The study involved 61 participants, averaging 49 years old. Almost half (47.5%) had completed high school. Qualitative data analysis revealed 9 thematic categories. Regarding the first question, 2 divergent categories emerged: care for life and threatening treatment. For the second question, opinions diverged into 4 categories: At an early stage, mid-course of the disease, as late as possible, and no time at all. For the third question, 3 categories emerged: communication and support, care setting and environment, and improving the PC experience.

Significance of Results

This study reveals diverse perspectives on patients’ awareness and preferences for discussing PC, challenging the misconception that it’s only for end-of-life (EOL) situations. Comprehending PC influences when and how patients discuss it. If tied solely to EOL scenarios, discussions may be delayed. Conversely, understanding its role in enhancing advance support encourages earlier conversations. Limited awareness might delay talks, while informed patients actively contribute to shared decision-making. Some patients prefered early involvement, others find mid-treatment discussions stress-relieving. Community support, quiet environments, and accessible resources, underscoring the importance of a calm, empathetic approach, emphasizing the importance of understanding its role in advance support and providing valuable implications for enhancing patient care practices, theories, and policies.