bluuebunny/crossref_metadata_2025 huggingface dataset:
Traumatología y Ortopedia Generalidades Vol. 4
Authors: Mendoza Agusto Anthony Iván , Vega Gordon Karla Elizabeth , Rivadeneira Jurado Héctor Agustin , González Fuenmayor Marco Antonio , Jaramillo Villalobos Johanna Sofía , Rivadeneira Jurado Elías Agustín , Carrillo Carrillo Fredy Javier , Alarcon Segovia Israel Alberto
Published: March 2023

La traumatología y la ortopedia son áreas esenciales de la medicina que abordan una amplia gama de lesiones y trastornos del sistema musculoesquelético. La evolución de la tecnología médica y la continua investigación en el campo de la traumatología y la ortopedia han llevado a una mejora en la comprensión de los mecanismos de lesiones y el desarrollo de nuevas técnicas de tratamiento. Es importante que los médicos y especialistas en traumatología y ortopedia estén actualizados con los avances recientes y puedan ofrecer un enfoque integral y actualizado en el manejo de las condiciones de sus pacientes. Este volumen se centra en la presentación de generalidades relevantes para la práctica diaria de los médicos y especialistas en traumatología y ortopedia, lo que lo convierte en una herramienta esencial para mejorar la atención médica en esta especialidad.
Evaluation of Physicochemical Parameters of Lake Mechefera for Fish Culture, Ethiopia
Authors: Misebo Tsegaye Dobamo , Wanore Denebo Sebaro , Ayano Wondimu Ersino , Gute Rediet Markos , Badulo Tesfaye Lamore
Published: March 2023

Optimum fish production is dependent on the quality of the water. Hence, an investigation on standard water quality requirements for fish culture is very important. The present study was aimed at investigating the water quality of Lake Mechefera for suitability of fish culture in Misrak Badawacho district, Southern Ethiopia. For the laboratory investigation, samples of the water from Lake Mechefera were collected according to standard laboratory guideline for the analysis of water quality parameters. The following water quality parameters were measured in the laboratory and in the field: temperature (thermometer); pH (pH meter); electrical conductivity (conductivity meter); total dissolved solids (volumetric analysis); turbidity (Secchi disk), total hardness (titration method), dissolved oxygen (winkler method), and biological oxygen demand (BOD incubator model. The mean and standard deviation of the results obtained were: pH (8.59±0.01), electrical conductivity (6.23±0.08 μs/cm), temperature (21.43±1.20C), total dissolved solids (1162mg/l to 1329 mg/l), turbidity (3.26±0.15 NTU), total hardness (98.2±0.65 mg/l), dissolved oxygen (4.09±0.51) and biological oxygen demand (4.08±0.64). Generally, most of the water quality parameters evaluated in this study were within the range recommended for fish culture. The implications are that the water sampled in the Lake Mechefera is fit for fish culture with some modification of the water parameters. Further study is needed on phytoplankton diversity and the other remaing water paramers.
Effect of Acute Toxicity of Lead Nitrate on Serum Biochemical and Enzymological Parameters of Indian Major Carp, Labeo rohita
Authors: Vijayadurga G. , Shameem U. , Paul Vanya , Kumar P. P. N. Vijay
Published: March 2023

To determine the LC 50 value of lead nitrate, Labeo rohita were exposed to different concentrations of the heavy metal through static assay method. LC50 value was calculated by employing Probit analysis and its acute toxicity was found to be 851mg/L. The acute toxic effect of lead nitrate on serum biochemical parameters of Labeo rohita were studied through 96-hour acute toxicity assay. Significant alterations were noticed in serum biochemical parameters viz. Total protein, Albumin, Globulin, and enzymes like Serum glutamate oxalate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT) and Alkaline phosphatase (ALP). There was an increase in the mean values of total protein, albumin, globulin, SGOT, SGPT and ALP in lead nitrate exposed fishes when compared to the control fishes, but fluctuations were noticed in the ALP mean values.
The Language Question: Considering Three Somali American Students With Autism
Authors: BAKER DIANA
Published: March 2023

Little research addresses the experiences of students with autism living in multilingual families. This multiple case study project examines the language-development-related knowledge and beliefs of paired mothers and educators of three Somali American boys with autism. Data include serial interviews, observations, and analysis of educational documents. Five distinct themes emerged from this study: (a) individuals with autism benefit from exposure to multiple languages, (b) the belief that multilingualism can be confusing for individuals with autism, (c) families value home language exposure, (d) educators are uncertain about providing language recommendations, and (e) information about students' multilingual context is virtually absent from educational documents and Individualized Education Program (IEP) meetings. With these findings in mind, implications for practice are discussed.
Culturally Responsive Practice for Teacher Educators: Eight Recommendations
Authors: BAUMGARTNER DANA , BAY MARY , LOPEZ-REYNA NORMA A. , SNOWDEN PEGGY A. , MAIORANO MICHAEL J.
Published: March 2023

In this article, we argue for the importance of all teacher educators engaging in a culturally responsive practice in their university classrooms. Whereas the literature is replete with recommendations regarding the use of a culturally responsive practice in P-12 settings, it is virtually silent on the use of such a practice in higher education settings. Given the changing demographics in our nation's schools, including in postsecondary settings, we strongly suggest this practice to maximize teacher candidates' learning and to influence their choice of teaching strategy and philosophy. We propose eight university teaching recommendations that are research-based and drawn from the work of various scholars who offer well-conceptualized and comprehensive texts that describe a culturally responsive practice.
Question-Asking and Advocacy by African American Parents at Individualized Education Program Meetings: A Social and Cultural Capital Perspective
Authors: WILSON NATASHA M.
Published: March 2023

The Individuals with Disabilities Education Improvement Act of 2004 mandates parental involvement during Individualized Education Program (IEP) meetings. Several factors including previous IEP experiences, level of ongoing communication between parents and education professionals, or existence of social and cultural capital resources can impact involvement. African American parents with low educational attainment or from low socioeconomic status (SES) backgrounds can be at risk for lower levels of involvement. With in-depth, semistructured interviews, this exploratory study examines two critical communicative dialoguing skills that parents at risk for lower levels of involvement often lack: question asking and advocacy. Eight African American parents (across socioeconomic and educational backgrounds) recalled questions asked and advocacy statements made at previous IEP meetings. Using grounded theory analysis, Strauss and Corbin (1998) showed that collaboration and communication occurred in areas mandated by law, but parents were largely unguided in asking their own questions or making statements. While many participants recalled high levels of involvement in the IEP process via question asking and advocacy, they drew on contacts and specific knowledge that at-risk parents do not typically have. Implications for parents with limited social or cultural capital are discussed, and a model approach to increase parental involvement based on innovations in patient–provider research is explored.
Risk in Schooling: The Contribution of Qualitative Research to Our Understanding of the Overrepresentation of Minorities in Special Education
Authors: HARRY BETH , FENTON PATRICE
Published: March 2023

This article reviews 15 qualitative studies examining factors contributing to the overrepresentation of minorities in special education. Eleven studies constituted numerical surveys of practitioner perspectives, with additional questions that were analyzed qualitatively. Four studies relied on face-to-face interviews or qualitative surveys, in-field observations, and review of students' documents. This review is organized into two main groups of studies—those that investigated stakeholders' explanations only and those that combined stakeholders' perspectives with direct investigation of actual practices. Findings reflected considerable overlap in explanations for disproportionality including poverty, family issues, intrinsic child deficit, and school-based issues such as professional bias regarding socioeconomic status (SES) and race. The article calls for increased use of qualitative studies to unearth the root causes of disproportionality.
Historical and Legal Overview of Special Education Overrepresentation: Access and Equity Denied
Authors: FORD DONNA Y. , RUSSO CHARLES J.
Published: March 2023

The history of the denial of equal education opportunities to Black children is a long one, whether through racial segregation or overrepresentation in special education. No other group is as overreferred, overidentified, and overrepresented in special education as Black students, specifically Black males. The authors present an historical and legal overview of special education and critique in the 2015 report by Morgan, Farkas, Hillemeier, Mattison, Maczuga, Li, and Cook. Based on their analysis of limited criteria rather than comprehensive criteria, Morgan and colleagues claim that Blacks were not overrepresented in special education and that more should have been identified. This study created a swelter of discussion and debates that are not new but that the authors find to be biased, polemic, and deficit-oriented assertions. The potential impact of Morgan et al.'s work (arguments, findings, and conclusions) must be interrogated rather than discounted.
Exploring the Challenges and Benefits to Inclusive Education in Jordanian UNRWA Schools
Authors: RODRIGUEZ JACQUELINE
Published: March 2023

Educating refugee children with special educational needs (SENs) is often impeded because of obstacles associated with their displacement. United Nations agencies such as the United Nations Relief and Works Agency for Palestine Refugees in the Near East, or the UNRWA, are often required to address the absence of government infrastructure by providing educational opportunities for children in conflict and fragile areas. However, in reviewing the literature on the education of Palestine refugee students in UNRWA schools, the extent to which this includes a focus on those students with SENs is limited. Accordingly, a comprehensive case study of inclusive education in three UNRWA schools was conducted in 2012–2013 during the author's tenure at the agency. The following study examined the perceptions of the benefits and challenges associated with inclusive education in schools operated by the Jordan field of UNRWA. Through multiple embedded case studies, interviews and observations were conducted with internal and external stakeholders, respectively, to explore inclusive education. The results indicate that stakeholders identified challenges to inclusive education three times as much as benefits. As the UNRWA implements a new inclusive education policy, attending to the concerns of local stakeholders, including students with SENs and their families, will be imperative to the successful provision of inclusive education. Therefore, leveraging the benefits to inclusive education as described by study participants will be an important catalyst toward fully including all students in UNRWA schools.
Demographic Imperatives for Educational Reform for Culturally and Linguistically Diverse Students
Authors: Yates James
Published: March 2023

Rapid demographic changes in culture, race/ethnicity, and language in the United States have exerted a powerful influence on public schools, raising significant concerns or issues relative to the ability of the educational system to successfully educate all of its children as future citizens of a democratic society. Educational outcome data for students from nondominant sociocultural and linguistic backgrounds highlight the failure of public schools to successfully educate all students. This lack of success is reflected in higher rates of retention, attrition, and placement in special education; lower rates of high school graduation and college entrance; and fewer degrees awarded. Implications for the future of society and policy priorities are suggested.
Intersectional Needs Politics: A Policy Frame for the Wicked Problem of Disproportionality
Authors: Mccall Zach , Skrtic Thomas
Published: March 2023

The disproportionate representation of poor, working class, and racial/ethnic minority students in special education is a wicked policy problem because its formulation involves choosing among alternative problem interpretations and associated consequences. Integrating the work of Patricia Hill Collins and Nancy Fraser, the authors propose intersectional needs politics as a two-part meta-frame for conceptualizing the disproportionality problem, which they use to show how an interplay of individual and structural forces has shaped the relationship between oppression and activism in the disability rights and civil rights movements, and to argue that framing disproportionality solely as a problem of special education practice ignores a key institutional function of special education in an unequal, stratifi ed, and racialized education system. They also use the meta-frame to show how provisions of the Individuals with Disabilities Education Act perpetuate the disproportionality problem and on this basis offer recommendations that they believe are essential for its just resolution.
A Self-Study of Diversity: Preservice Teachers' Beliefs Revealed Through Classroom Practices
Authors: Sobel Donna , Taylor Sheryl , Kalisher Shannon , Weddle-steinberg Rachel
Published: March 2023

The authors present the results of a self-study by seven preservice teachers that reveals ways in which the teachers' beliefs regarding diversity issues were realized in their classroom interactions, practices, and observations. This investigation was set within the context of a cohort of postbaccalaureate preservice teachers in an initial teacher education program that is built around the goal of preparing reflective teachers. It provided the framework for preservice teachers to raise their level of awareness regarding issues of diversity. The identification of common themes in the participants' journals provided insights into how these beliefs may link to future classroom teaching practice and ways teacher educators can help preservice teachers to view their students' backgrounds and abilities as resources, not problems.
Effects of Failure Free Reading on Culturally and Linguistically Diverse Students with Learning Disabilities
Authors: England Grace , Collins Sara , Algozzine Bob
Published: March 2023

Reading problems are among the most prevalent concerns for general and special educators who teach culturally and linguistically diverse students with learning disabilities. In this study, 60 students with serious reading problems were taught word recognition and comprehension skills using the Failure Free Reading Program. This intervention is based on effective teaching principles identified in successful reading programs. Key steps in the program included (a) previewing the story, (b) listening to the story being read, (c) presenting content from the story, (d) reading the story, and (e) reviewing the story. Improved performance in letter and word identification, word attack skills, reading comprehension, and dictation were observed after intensive intervention procedures were implemented. The results showed that discrepancies between intellectual ability and reading achievement decreased in more than half of the students. Discussion is focused on the implications of the Failure Free Reading Program as an effective intervention program for improving the reading achievement levels of ethnically diverse students with learning disabilities.
To what Extent are Transition Components of Individualized Education Programs for Diverse Students with Learning Disabilities Culturally Responsive?
Authors: Trainor Audrey
Published: March 2023

Transition planning with students with learning disabilities (LD) from culturally and linguistically diverse backgrounds presents unique challenges to the implementation of recommended practices and mandates such as individualization, incorporation of student preferences; encouragement of self-determination; collaboration with parents and professionals; and generation of goals and objectives that address academic, social, and life skills. This document review, part of a larger qualitative interview study, examined the individual transition plans of 15 high school students with LD to determine the extent to which the content of the plans reflected legal mandates, contained evidence of recommended practices, and was culturally responsive to meet the needs of diverse students. Results indicated that most documents were minimally compliant with legal mandates, yet they contained little evidence to support the implementation of recommended practices. Most significantly, there was no indication of individualization, indicating a general lack of culturally responsive transition practices. The author includes recommendations for research and practice.
Papilionidae de la Colección de Entomología del Museo de Historia Natural (MHN-UniCauca), Popayán, Cauca, Colombia (Insecta: Lepidoptera)
Authors: Gallego-Ropero María Cristina , Villalobos-Moreno Alfonso , Gallego-López Ángela Patricia , Salazar Julián A.
Published: March 2023

Se revisaron 199 ejemplares de la familia Papilionidae depositados en la Colección de Entomología del Museo de Historia Natural de la Universidad del Cauca (MHN-UniCauca), Popayán, Cauca, Colombia. El material biológico ha sido recolectado por estudiantes, profesores e investigadores desde los años 1940s hasta la fecha. Se identificaron nueve géneros, 40 especies y 58 subespecies. Las especies más abundantes fueron H. thoas neacles (Rothschild & Jordan, 1906) (10), H. paeon thrason (Felder & Felder, 1865) (10), P. telesilaus (Felder & Felder, 1864) (10), E. serville acritus (Rothschild & Jordan, 1906) (9) y P. eurimedes agathokles (Kollar, 1850) (9),mientras que 20 subespecies estuvieron representadas por un solo espécimen. Se realizaron análisis descriptivos sobre la actividad de recolección del material biológico y de los recolectores mismos, desde la creación de la Colección de Entomología hasta la fecha, así como sobre la distribución altitudinal y geográfica. El análisis de la calidad del inventario estableció que la riqueza potencial de subespecies de la familia Papilionidae en la Colección de Entomología de la Universidad de Cauca es de 83,73 (pendiente = 0,21; porcentaje de especies observadas = 59,72), lo cual indica que aunque el número de subespecies registradas es alto y la calidad del inventario es aceptable, faltan subespecies de Papilionidae por ser registradas para la zona.
The taxonomic position of Cabralia trifasciata Moore, 1882 (Lepidoptera: Noctuidae, Noctuinae, Phosphilini)
Authors: Becker Vitor O.
Published: March 2023

Cabralia trifasciata Moore, 1882 is transferred from the Ophiderinae (Erebidae), to the Noctuidae: Noctuinae, Phosphilini and Cromobergia Bourquin, 1937 (= Cabralia Moore, 1882), Cucullia teichii Berg, 1885, and Speocropia similacis Bourquin, 1937, syn. nov. are recognized as junior subjective synonyms of Cabralia trifasciata Moore, 1882.
مدى شرعية أسانيد سيادة إسرائيل على القدس في القانون الدولي العام
Authors: أحمد أبو الخير السيد
Published: March 2023

القدس أولى القبلتين وثالث الحرمين، مسرى رسول الله صل الله عليه وسلم، وهى الأرض التي بارك الله فيها وحولها، وعروس العروبة، قلب فلسطين النابض، تعرضت للمؤامرات كبقية فلسطين المحتلة، بل حظها من المؤامرات كان أكثر وأكبر، في هذا البحث المعنون بمدى شرعية أسانيد سيادة إسرائيل على القدس في القانون الدولي العام، وهى الأسانيد التي ذكرت في بيان إعلان استقلال دولة إسرائيل في 15/مايو 1948م في تصريح بلفور وصك الانتداب وتوصية التقسيم بقرار الجمعية العامة للأمم المتحدة رقم (181) لسنة 1947م، وهى التي تعتمد عليها إسرائيل في بسط سيطرتها على القدس الشريف، وسوف نتعرض بالدراسة لكل سند منها في مبحث مستقل طبقاً لقواعد وأحكام القانون الدولي العام في عهد العصبة وفي ميثاق الأمم المتحدة وقرارات الجمعية العامة ومجلس الأمن، لنرى مدى شرعيتها من عدمه، وهل تتفق مع القانون الدولي أم تخالفه.
الضمانات القانونية والقضائية والدستورية لسيادة القانون
Authors: عبدالرحمن باهر
Published: March 2023

بيد أن سيادة القانون هو أصل من الأصول الدستورية ويترتب عليه أنه لا يمكن للسلطات العامة القائمة في بلد ما أن تمارس سلطتها إلا وفق قوانين مكتوبة صادرة وفقاً للدستور، والهدف منها تحقيق مبدأ الحماية ضد القوانين والقرارات التعسفية.

فلا يؤسس الدستور نظاماً ديمقراطياً إلا بقدر احتوائه وإقراره الحقوق والحريات العامة التي يتمتع بها كافة المواطنين على السواء بدون تفرقة أو تمييز، وفى نفس الوقت يوفق ويوازن بين هذه الحقوق وتلك الحريات وبين السلطة والنظام بصورة معقولة واضحة لا لبس فيها.

ويُعدّ تطبيق مبدأ سيادة القانون أحد العوامل الهامة والمؤثرة بل والمشجعة على استقطاب رؤوس الأموال المحلية والأجنبية، وزيادة فرص الاستثمار في المجتمع بما يحقق عائداً إيجابياً على الدولة كما أن الرخاء الاقتصادي يترتب عليه خلق فرص عمل والقضاء على البطالة، مما يحقق الأمن المجتمعي، باعتبار أن الرخاء الاقتصادي أحد العوامل الهامة في تحقيق الاستقرار، ويُعدّ من أهم ضمانات تنفيذه وتطبيقه راجعة إلى أعمال السلطة التنفيذية المناط بها تطبيق مبدأ سيادة القانون وتطبيقه.
Una mirada reflexiva a la Calidad de la Educación Superior
Authors: Camputaro Luis Alberto , Tamayo Ortíz Jose Luis
Published: March 2023

Introducción: Análisis crítico interpretativo sobre la calidad en Educación Superior, repasando aspectos considerados para ser de calidad en la actualidad con todos los cambios generados en el pasado. Desarrollo: Se centra en siete aspectos: Modelo de Universidad; Universidad de Clase Mundial o Local; Evolución de la Educación Superior; Tecnologías; La Calidad en Educación Superior como motor de cambio social pertinente; La inclusión social; y La Evaluación y Acreditación como control de Calidad. Conclusión: El compromiso de las agencias internacionales para la educación superior, asociado a la participación de redes y agencias de control y aseguramiento de calidad han sido impulsores y favorecedores de esta tendencia en América Latina y el Caribe, siendo sus elementos más significativos la evaluación y acreditación de la calidad, pasando de ser una recomendación teórica a una política efectivamente implementada, al igual que en otras regiones del mundo.
Moterų veiklos Lietuvos Aukščiausioje Taryboje diegiant vertybines nuostatas viešojoje politikoje
Authors: Jurėnienė Virginija , Purvaneckienė Giedrė
Published: March 2023

Aukščiausios Tarybos-Atkuriamojo Seimo parlamentarių indėlis į naujos viešosios politikos kūrimą per demokratiškai išrinkto parlamento priimtus įstatymus, parodant rinkimų kampanijos metu moterų organizacijų ir judėjimų kurtas platformas ir jų programas, nėra tirtas. Sąjūdžio ir LKP bei kitų atsikūrusių ir susikūrusių partijų rinkiminės kampanijos yra plačiai analizuotos, tačiau tame kontekste neliko atsikūrusių moterų organizacijų iškeltų moterų kandidačių, remtų ir neremtų Sąjūdžio į LTSR AT. Straipsnyje, remiantis archyviniais šaltinais ir tuometine spauda, parodoma rinkiminė kova ir tuo metu veikiančių moterų organizacijų ir moterų judėjimų (Motinų, Moterų Sąjūdžių) kuriamos rinkiminės platformos. Taip pat analizuojama išrinktų į XII šaukimo LTSR Aukščiausiąją Tarybą – Lietuvos Aukščiausiąją Tarybą keturiolikos moterų veikla. Pažymėtina, jog didžiausias jų dėmesys buvo sutelktas į įstatymų projektų pasiūlymus, susijusius su šeima, moterimis, vaikais. Nebuvo nei vieno pasiūlyto įstatymo projekto, kaip apsaugoti moteris darbo rinkoje, bet buvo teikiami įstatymų projektai, grąžinantys jas į šeimą. Tai buvo neatsitiktinis reiškinys, nes Lietuvos Persitvarkymo Sąjūdžio ir jo moterų rėmimo grupėse, pvz. „Saulėtekis“, Motinų ir Moterų sąjūdžiai programose akcentavo šeimos stiprinimo klausimą, tačiau jam išspręsti siūlė tik vieną kelią – „moteris grąžinti į šeimą“, neatsižvelgiant į tuo metu jau Statistikos departamento ir mokslininkų vykdytus tyrimus apie moterų išsakomą poziciją šiuo klausimu. Tai „buldozerinės“ politikos Lietuvoje pavyzdys, kuris turėjo ilgalaikes negatyvias pasekmes Lietuvos visuomenei ir ypač moterims. Straipsnio tikslas – atskleisti moterų parlamentarių indėlį į naujos  viešosios politikos kūrimą per Lietuvos Aukščiausios Tarybos priimtus įstatymus, parodant rinkiminės kampanijos metu moterų organizacijų ir judėjimų kurtas platformas. Straipsnyje naudoti tyrimo metodai: mokslinės literatūros  lyginamoji analizė, dokumentų analizė, pirminių (archyvinių dokumentų) ir antrinių (tuometinės spaudos) šaltinių analizė ir sintezė), kokybinis tyrimas  (interviu).
Good Practices in Inter-Institutional Collaboration in Managing the Migrant Crisis
Authors: Smaliukienė Rasa , Giedraityte Vidmante , Grincevičiūtė Ingrida , Ungurytė - Ragauskienė Svajūnė
Published: March 2023

In 2021, Lithuania faced the challenge of managing the crisis of new type of migration across the Belarusian border, which threatened the security of the country and its citizens. A broad set of inter-institutional collaboration strategies and methods were used among the public institutions to address this crisis. Such inter-institutional collaboration has been a multifaceted and complex process, involving both known and new good practices. The aim of this article is to provide insights into good collaborative practices between the Lithuanian national defence and internal affairs systems in managing the migrant crisis. Following the expert interview results,  the study identified three good practices of inter-institutional collaboration: (i) the creation of a single dissemination channel for the crisis response services, which ensured that all actors were in the same information field; (ii) the delegation of representatives of the institutions to teams at strategic, operational and tactical levels; and (iii) inter-institutional information sharing ensured good situational awareness at an early stage of emergency management. Lessons learned from the collaboration between the institutions of the national defence and internal affairs systems can be applied to improve inter-institutional collaboration in other areas. The research results can be used to enhance the process of such collaboration in addressing current emergency management issues and serve as a basis for effective and smooth emergency preparedness and response where inter-institutional synergy is needed.
A bioinformatics approach to characterize a hypothetical protein Q6S8D9_SARS of SARS-CoV
Authors: Rahman Md. Foyzur , Hasan Rubait , Biswas Mohammad Shahangir , Shathi Jamiatul Husna , Hossain Md. Faruk , Yeasmin Aoulia , Abedin Mohammad Zakerin , Hossain Md. Tofazzal
Published: March 2023

Characterization as well as prediction of the secondary and tertiary structure of hypothetical proteins from their amino acid sequences uploaded in databases by in silico approach are the critical issues in computational biology. Severe acute respiratory syndrome–associated coronavirus (SARS-CoV), which is responsible for pneumonia alike diseases, possesses a wide range of proteins of which many are still uncharacterized. The current study was conducted to reveal the physicochemical characteristics and structures of an uncharacterized protein Q6S8D9_SARS of SARS-CoV. Following the common flowchart of characterizing a hypothetical protein, several sophisticated computerized tools e.g., ExPASy Protparam, CD Search, SOPMA, PSIPRED, HHpred, etc. were employed to discover the functions and structures of Q6S8D9_SARS. After delineating the secondary and tertiary structures of the protein, some quality evaluating tools e.g., PROCHECK, ProSA-web etc. were performed to assess the structures and later the active site was identified also by CASTp v.3.0. The protein contains more negatively charged residues than positively charged residues and a high aliphatic index value which make the protein more stable. The 2D and 3D structures modeled by several bioinformatics tools ensured that the proteins had domain in it which indicated it was functional protein having the ability to trouble host antiviral inflammatory cytokine and interferon production pathways. Moreover, active site was found in the protein where ligand could bind. The study was aimed to unveil the features and structures of an uncharacterized protein of SARS-CoV which can be a therapeutic target for development of vaccines against the virus. Further research are needed to accomplish the task.
A Python-based educational software tool for visualizing bioinformatics alignment algorithms
Authors: Khatizah Elis , Nam Hee-Jo , Park Hyun-Seok
Published: March 2023

Bioinformatics education can be defined as the teaching and learning of how to use software tools, along with mathematical and statistical analysis, to solve biological problems. Although many resources are available, most students still struggle to understand even the simplest sequence alignment algorithms. Applying visualizations to these topics benefits both lecturers and students. Unfortunately, educational software for visualizing step-by-step processes in the user experience of sequence alignment algorithms is rare. In this article, an educational visualization tool for biological sequence alignment is presented, and the source code is released in order to encourage the collaborative power of open-source software, with the expectation of further contributions from the community in the future. Two different modules are integrated to enable a student to investigate the characteristics of alignment algorithms.
In silico annotation of a hypothetical protein from Listeria monocytogenes EGD-e unfolds a toxin protein of the type II secretion system
Authors: Tasneem Maisha , Gupta Shipan Das , Momin Monira Binte , Hossain Kazi Modasser , Osman Tasnim Binta , Rabbi Md. Fazley
Published: March 2023

The gram-positive bacterium Listeria monocytogenes is an important foodborne intracellular pathogen that is widespread in the environment. The functions of hypothetical proteins (HP) from various pathogenic bacteria have been successfully annotated using a variety of bioinformatics strategies. In this study, a HP Imo0888 (NP_464414.1) from the Listeria monocytogenes EGD-e strain was annotated using several bioinformatics tools. Various techniques, including CELLO, PSORTb, and SOSUIGramN, identified the candidate protein as cytoplasmic. Domain and motif analysis revealed that the target protein is a PemK/MazF-like toxin protein of the type II toxin-antitoxin system (TA) which was consistent with BLASTp analysis. Through secondary structure analysis, we found the random coil to be the most frequent. The Alpha Fold 2 Protein Structure Prediction Database was used to determine the three-dimensional (3D) structure of the HP using the template structure of a type II TA PemK/MazF family toxin protein (DB ID_AFDB: A0A4B9HQB9) with 99.1% sequence identity. Various quality evaluation tools, such as PROCHECK, ERRAT, Verify 3D, and QMEAN were used to validate the 3D structure. Following the YASARA energy minimization method, the target protein's 3D structure became more stable. The active site of the developed 3D structure was determined by the CASTp server. Most pathogens that harbor TA systems create a crucial risk to human health. Our aim to annotate the HP Imo088 found in Listeria could offer a chance to understand bacterial pathogenicity and identify a number of potential targets for drug development.
Prognostic biomarkers and molecular pathways mediating Helicobacter pylori–induced gastric cancer: a network-biology approach
Authors: Kamarehei Farideh , Saidijam Massoud , Taherkhani Amir
Published: March 2023

Cancer of the stomach is the second most frequent cancer-related death worldwide. The survival rate of patients with gastric cancer (GC) remains fragile. There is a requirement to discover biomarkers for prognosis approaches. Helicobacter pylori in the stomach is closely associated with the progression of GC. We identified the genes associated with poor/favorable prognosis in H. pylori–induced GC. Multivariate statistical analysis was applied on the Gene Expression Omnibus (GEO) dataset GSE54397 to identify differentially expressed miRNAs (DEMs) in gastric tissues with H. pylori–induced cancer compared with the H. pylori–positive with non-cancerous tissue. A protein interaction map (PIM) was built and subjected to DEMs targets. The enriched pathways and biological processes within the PIM were identified based on substantial clusters. Thereafter, the most critical genes in the PIM were illustrated, and their prognostic impact in GC was investigated. Considering p-value less than 0.01 and |Log2 fold change| as >1, five microRNAs demonstrated significant changes among the two groups. Gene functional analysis revealed that the ubiquitination system, neddylation pathway, and ciliary process are primarily involved in H. pylori–induced GC. Survival analysis illustrated that the overexpression of DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, and TXNIP was associated with poor prognosis, while increased MRPS5 expression was related to a favorable prognosis in GC patients. DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, TXNIP, and MRPS5 may be considered prognostic biomarkers for H. pylori–induced GC. However, experimental validation is necessary in the future.
Introduction of the Korea BioData Station (K-BDS) for sharing biological data
Authors: Lee Byungwook , Hwang Seungwoo , Kim Pan-Gyu , Ko Gunwhan , Jang Kiwon , Kim Sangok , Kim Jong-Hwan , Jeon Jongbum , Kim Hyerin , Jung Jaeeun , Yoon Byoung-Ha , Byeon Iksu , Jang Insu , Song Wangho , Choi Jinhyuk , Kim Seon-Young
Published: March 2023

A wave of new technologies has created opportunities for the cost-effective generation of high-throughput profiles of biological systems, foreshadowing a "data-driven science" era. The large variety of data available from biological research is also a rich resource that can be used for innovative endeavors. However, we are facing considerable challenges in big data deposition, integration, and translation due to the complexity of biological data and its production at unprecedented exponential rates. To address these problems, in 2020, the Korean government officially announced a national strategy to collect and manage the biological data produced through national R&D fund allocations and provide the collected data to researchers. To this end, the Korea Bioinformation Center (KOBIC) developed a new biological data repository, the Korea BioData Station (K-BDS), for sharing data from individual researchers and research programs to create a data-driven biological study environment. The K-BDS is dedicated to providing free open access to a suite of featured data resources in support of worldwide activities in both academia and industry.
Cinnamic acid derivatives as potential matrix metalloproteinase-9 inhibitors: molecular docking and dynamics simulations
Authors: Malekipour Mohammad Hossein , Shirani Farzaneh , Moradi Shadi , Taherkhani Amir
Published: March 2023

Matrix metalloproteinase-9 (MMP-9) is a zinc and calcium-dependent proteolytic enzyme involved in extracellular matrix degradation. Overexpression of MMP-9 has been confirmed in several disorders, including cancers, Alzheimer′s disease, autoimmune diseases, cardiovascular diseases, and dental caries. Therefore, MMP-9 inhibition is recommended as a therapeutic strategy for combating various diseases. Cinnamic acid derivatives have shown therapeutic effects in different cancers, Alzheimer′s disease, cardiovascular diseases, and dental caries. A computational drug discovery approach was performed to evaluate the binding affinity of selected cinnamic acid derivatives to the MMP-9 active site. The stability of docked poses for top-ranked compounds was also examined. Twelve herbal cinnamic acid derivatives were tested for possible MMP-9 inhibition using the AutoDock 4.0 tool. The stability of the docked poses for the most potent MMP-9 inhibitors was assessed by molecular dynamics (MD) in 10 nanosecond simulations. Interactions between the best MMP-9 inhibitors in this study and residues incorporated in the MMP-9 active site were studied before and after MD simulations. Cynarin, chlorogenic acid, and rosmarinic acid revealed a considerable binding affinity to the MMP-9 catalytic domain (ΔGbinding < -10 kcal/mol). The inhibition constant value for cynarin and chlorogenic acid were calculated at the picomolar scale and assigned as the most potent MMP-9 inhibitor from the cinnamic acid derivatives. The root-mean-square deviations for cynarin and chlorogenic acid were below 2 Å in the 10 ns simulation. Cynarin, chlorogenic acid, and rosmarinic acid might be considered drug candidates for MMP-9 inhibition.
PyOncoPrint: a python package for plotting OncoPrints
Authors: Park Jeongbin , Paramasivam Nagarajan
Published: March 2023

OncoPrint, the plot to visualize an overview of genetic variants in sequencing data, has been widely used in the field of cancer genomics. However, still, there have been no Python libraries capable to generate OncoPrint yet, a big hassle to plot OncoPrints within Python-based genetic variants analysis pipelines. This paper introduces a new Python package PyOncoPrint, which can be easily used to plot OncoPrints in Python. The package is based on the existing widely used scientific plotting library Matplotlib, the resulting plots are easy to be adjusted for various needs.
Thin-Film Coupling Membrane
Authors:   University of Waterloo, Ginzel Edward ,   Innovation Polymers, MacNeil Rick ,   Innovation Polymers, Molina Mauricio
Published: March 2023

When using ultrasonic probes with removable wedges, the acoustic coupling between wedge and probe is usually
effected by means of a gel or grease. This tends to evaporate over time and requires occasional replacement of the
gel. In manual ultrasonic testing, where the kit is disassembled daily or when the wedges are often replaced with
different angled wedges, this is not usually a problem. However, in a production environment where the same
probe and wedge may be used for several days at a time, the requirement to re-couple the probe to the wedge might
be inconvenient. This paper provides a description of a solid thin-film coupling material that can significantly
prolong the interval between re-coupling.
Thorn
Authors: Fatemi Erik ,   After Dinner Conversation
Published: March 2023

How does our own perspective limit our ability to understand the different perspectives of others, and what can we do to minimize our own bias? In this work of historical ethical fiction, Timothy the builder, the most important carpenter in the community, has gotten word of a talented upstart who seems perfectly content to stay poor while producing exquisite wood work. Timothy visits the carpenter on several occasions, first to hire him (he refuses) then to threaten to put him out of business. In each case Timothy is unable believe the reasons the carpenter gives for being disinterested in playing the competing businesses game. Even after Timothy’s loyal assistant leaves him for the carpenter, he is still unable to overcome his own bias and see the alternative perspective.
Mental health care before and during the COVID-19 pandemic in public healthcare centers of a Chilean municipality
Authors: Soledad Andrea San Martín , María Teresa Muñoz-Quezada
Published: March 2023

Introduction Globally, the COVID-19 pandemic has affected people’s mental health care. This study aims to describe mental health care in the first semester of the COVID-19 pandemic of the year 2020 compared to the first semester of the year 2019 in the public health establishments of the commune of Chillán, Chile. Methods A descriptive ecological study. The treated cases were analyzed in aggregate, considering the pandemic, amount of admissions, the reason for consultation, sex, and age for the years 2019 and 2020. Prevalence, percentages, and statistical analysis were evaluated using non-parametric tests. Results The prevalence of cases due to admissions to the mental health program in primary health care remained similar between the first semester of 2019 and the first semester of 2020. Most mental health cases concentrate on mood (affective) and anxiety disorders. Statistically significant differences were observed between 2019 and 2020 in the number of mental health admissions for mental and behavioral disorders due to psychotropic substances, harmful use disorders, drug dependence, and personality disorders. Conclusions It is a priority for Chile to increase coverage in primary mental health care. The data provided in this study show at an exploratory level that the initial situation of the pandemic could have affected access to timely care for the most vulnerable people with mental disorders.
Compilation of state tax relating to oil, gas, and mining properties in New Mexico
Authors: Ripley E. P.
Published: March 2023

The numerous inquiries received by the New Mexico Institute of Mining and Technology and the State Bureau of Mines and Mineral Resources have indicated the need for a recompilation of the tax law relating to taxation of mineral properties within New Mexico.

Broadly speaking, there are three classes of taxes levied on mineral properties: (1) Ad Valorem and Production Taxes; (2) Severance Taxes, and (3) Sales Taxes. This recompilation will follow this division. In an effort to make the compilation of maximum benefit, reproductions of the forms currently in use by the Tax Commission and the Bureau of Revenue are appended. Decisions of the Supreme Court on the subject also are referred to. However, no attempt is made to cover court decisions in detail, their inclusion in abbreviated head-note form makes the full text readily available to interested persons. This compilation does not deal with corporate taxes nor the State income tax.

Citations are to New Mexico Session Laws and to 1941 New Mexico Compilation and Cumulative Pocket Supplement thereof (Boobs-Merrill Company, 1942).
Analisis Strategic Management Pada Bebek Gembul Resto
Authors: Susandy Rio Ageng Surya , Kusumaningrum Dewi Pramesti , Jawa Maria Margarith Stely Damian
Published: March 2023

The culinary industry is currently a mainstay because it provides the fastest surplus, both from the economic side of entrepreneurs, as well as from the government's income side through taxes paid. The purpose of this analytical research is to see, describe and provide recommendations related to marketing strategies in the culinary industry. This research method is a case study using SWOT analysis. The data used is primary data. While the type of research used is qualitative research. This technique explores information by using data sources from more than one point of view, such as journals, archives, articles and others. This study uses External Environmental Analysis and Internal Environmental Analysis of Bebek Gembul Resto. The results obtained from environmental analysis, SWOT analysis and strategy analysis are Bebek Gembul Resto for its strategy is good and adapts to technological developments and times. Starting from using food bloggers for promotions to frozen food innovations.
Electrode improvement and neural network-based dynamic optimization of vanadium redox flow battery
Authors:   , Chutimasakul Apisada
Published: March 2023

The performance improvement of a vanadium redox flow battery (VRFB) was focused on this study. The two objectives of this study were (1) to investigate the effect of the operating temperatures of the Atmospheric Pressure Plasma jets (APPJs) process on the energy efficiency of the VRFB and (2) to determine the optimal electrolyte flow rate of the VRFB by solving a dynamic optimization based on a neural network model of the VRFB. The APPJs graphite felt electrode treatment temperature providing the highest energy efficiency of the VRFB was 550°C, explained by the Energy Dispersive X-ray Spectrometry (EDX) and X-ray photoelectron spectroscopy (XPS) results. The EDX results indicated that the electrode treated with APPJs at 550°C had a high percentage of the oxygen atom, and XPS results illustrated the highest C=O functional group on the surface of APPJs at 550°C electrode comparing to the APPJs at other temperatures and sulfuric treatment. Moreover, the wettability of the electrode with APPJs treatment at all temperatures was higher improved than that with a sulfuric acid treatment and an untreated one. However, the electrode treatment did not visibly change the surface of the electrode, as shown in Scanning Electron Microscopy (SEM) results. In the second part of this study, an optimization of the electrolyte flow rate based on a neural network (NN) model of the VRFB was investigated. The NN was separately trained between the charging and discharging process using a nonlinear autoregressive with external input (NARX) model. The training and testing results indicated a high accuracy of the NN model. Under the optimal electrolyte flow rate obtained by solving the NN based-optimization, the VRFB  provided a high system efficiency (SE) due to reducing the concentration overpotential. It demonstrated that the NN model could replace the theoretical model used in the dynamic optimization, even though the performance of the VRFB under the optimal electrolyte flow rate obtained from the NN-based optimization is slightly lower than that from the theoretical model-based optimization.
Novel electrochemical packed-bed reactor for carbon dioxide reduction
Authors:   , Chaiwarit Suwakul
Published: March 2023

Electrochemical reduction of carbon dioxide (CO2) is a promising strategy to recycle CO2 into valuable chemical products. Nevertheless, a conventional apparatus which usually utilizes stack design to maximize its surface-to-volume ratio requires many elements and complicated instruction assembly. The stack design often requires feed streams to flow in narrow channels throughout the cell, which is also constrained by membrane size roughly 1 m2 by current manufacture technology. This research focuses on development of a new type of electrochemical reactor that is suitable for industrial-scale applications. The novel electrochemical packed-bed reactor is designed for the electroreduction to covert CO2 into CO in the gas phase. Humidified CO2 was fed through the reactor, and a voltage was applied to the bed for initiate electrochemical reactions. The bed consists of 3 compartments including Zinc (Zn) deposited felt, ion-exchange resin, and platinized titanium arranged in this order. Effects of applied voltage and CO2 flow rates toward the CO2 reduction performance was investigated. The increasing of CO concentration and current were achieved with increasing voltage. The maximum CO concentation and the highest faradaic efficiency were observed at 6 V and 80 ml min-1 for a single-cell bed. The optimal condition for a two-cell bed was 11 V and 120 ml min-1. However, the effects of flow rate might oppose effects of mass transfer at high flow rate. An online infrared spectroscopy was coupled to the novel electrochemical packed-bed reactor for the CO product detection. The CO product analysis confirmed that the novel electrochemical packed-bed reactor successfully converts CO2 to CO.