bluuebunny/crossref_metadata_2025 huggingface dataset:
PHENOTYPES OF GENETICALLY DETERMINATED FORMS OF OBESITY
Authors:   Academician I.P. Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia, Kuprienko N.B. ,   V.A. Almazov National Medical Research Centre of the Ministry of Healthcare of Russia, Saint Petersburg, Russia, Smirnova N.N. ,   Academician I.P. Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia,   V.A. Almazov National Medical Research Centre of the Ministry of Healthcare of Russia, Saint Petersburg, Russia
Published: March 2022

A review of domestic and foreign literature describes the phenotypes of genetically determined forms of obesity. Among non-syndromic monogenic forms of obesity, variants associated with mutations in the leptine and leptine receptors genes are particularly prominent. Several rare forms are caused by mutations in genes that regulate the development of the hypothalamus and central nervous system. Ciliary dysfunction is at the root of the group of hereditary disorders – ciliopathy, including Bardet–Biedl and Joubert syndromes and accompanied by varying degrees of obesity. The diagnostic criteria for the Prader–Willi, Bardet–Biedl, and Cohen syndromes are presented. It is noted that early onset of severe obesity and delayed mental development require timely genetic analysis and correction therapy.
SIGNIFICANCE OF CONGENITAL IMMUNITY DEFECTS IN THE STUDY OF EPIDEMIOLOGY OF HUMAN INFECTIOUS AND NON-INFECTIOUS DISEASES
Authors:   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Shcherbina A.Yu.
Published: March 2022

Primary immunodeficiencies (PID) are conditions caused by genetic defects in the immune system. Their main manifestation is an infectious syndrome (recurrent severe infections caused by common pathogens, with gross defects in immunity). However, as the PID study progressed, descriptions of patients with hypersensitivity to rare and opportunistic infections, mycobacterioses, including BCG infection, with severe/atypical course of common viral infections, including COVID-19, emerged. Due to the inability of the immune system of patients to control the oncogenic potential of various viruses, with defects in some immune mechanisms, these patients develop various tumors (Kaposi's sarcoma, EBV-associated smooth muscle tumor) or an increase in the frequency of, for example, EBV-associated lymphomas. The creation of the Russian register of PIDs makes it possible to predict the development of certain rare/opportunistic infectious and infectious diseases in the Russian Federation. The most important is the prevention of the development of rare/opportunistic infections by early detection of patients with PID and their pathogenetic treatment, including immunomodulatory, replacement therapy with human normal immunoglobulin preparations, as well as radical therapy – hematopoietic stem cell transplantation. In addition, an important epidemiological aspect of the study of PID is that patients are often unable to eliminate infectious pathogens for a long time and serve as a reservoir of various infections (vaccinal and wild strains of poliomyelitis, COVID-19).
PREDICTORS OF THE EFFECTIVENESS OF TREATMENT OF VESICOURETERAL REFLUX IN CHILDREN
Authors:   National Medical Research Center for Children’s Health, Moscow, Russia, Zorkin S.N. , Gurskaya A.S. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Baiazitov R.R. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Borisova S.A. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Karpachev S.A. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Shakhnovskiy D.S. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Uvarov B.N. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Galuzinskaya A.T. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Nikulin O.D. ,   National Medical Research Center for Children’s Health, Moscow, Russia
Published: March 2022

The article presents a modern view on the prognostic factors of spontaneous resolution and effectiveness of treatment of children with vesicoureteral reflux (VUR). The most frequently used predictors of successful treatment of VUR (grades of reflux, distal ureteral diameter ratio to the distance of the lumbar vertebrae, reflux induction phase on mictional cystourthrography), delayed removal of contrast from the upper urinary tract, gender, age, antenatal hydronephrosis). Methodology, statistical significance, advantages, disadvantages of the described prognostic factors are analyzed.
COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN: CORRECTING MISTAKES
Authors:   Belarusian State Medical University, Minsk, Republic of Belarus, Samal T.N. , Ukraintsev S.E. ,   People’s Friendship University of Russia, Moscow, Russia
Published: March 2022

The article describes typical and most common errors that cause underdiagnosis and overdiagnosis of community-acquired pneumonia (CAP) in children. The diagnostic criteria for confirming/eliminating the diagnosis are reviewed. Attention is drawn to the difficulties in interpreting of X-ray changes, establishing the etiology of CAP. Particular attention is paid to the principles of antibacterial therapy and the analysis of the main mistakes in the treatment of CAP in children.
English Language Teaching and Globalization: to Support Economic Growth
Authors: Adawiyah Dita
Published: March 2022

The English language is no doubt significant for communication in the international community. It may not be the most widely spoken language globally, but it is the official language in many countries. This paper aims to analyze why the English language plays a significant role in supporting economic growth and the factors that influence the use of the English language in the era of globalization. A function that helps people communicate promotes nation-to-nation development and builds relationships with other countries. The survey design used a survey, the type of survey used a descriptive survey, and the equipment used was student observation. The results show that the economy is becoming increasingly global, and more and more countries are turning to the English language for business reasons. In conclusion, the English language is a significant contributor to sustainable development, so those who do not speak the English language do not stand a chance.
Target Cultures Representation in English Course Books of Smart 10 and Bahasa Inggris X for Senior High School
Authors: Santi Dewi Mustika , Pratolo Bambang Widi
Published: March 2022

This research is aimed to analyze the target cultural classification aspects of High School textbooks. The data for analysis were collected from two High School books entitled Smart 10 and Bahasa Inggris X. The method employed was the descriptive qualitative method, and it used the theory from Dweik & Al-Sayyed (2015) about cultural classifications. This study explored and compared how the target culture was represented in two coursebooks that used purposive sampling. Three available units were selected in every book by employing systemic random sampling. Six aspects were analyzed; food & beverages, person's name, places, social behavior, ecology, and economy. The results showed that target cultures represented by Smart 10 are more dominant than in Bahasa Inggris X's book.
Tata Laksana Disfungsi Dasar Panggul Pascasalin
Authors:   KSM/ Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran/RSUP Dr. Hasan Sadikin Bandung, Sukarsa M. Rizkar Arev , Nurita Rena , Adha Melia Juwita
Published: March 2022

Tujuan: melakukan telaah literatur mengenai identifikasi dan tata laksana dini disfungsi dasar panggul pada onset baru atau lama. Gejala dan perubahan anatomis terkait disfungsi otot dasar panggul dapat berhubungan dengan hipertonisitas, hipotonisitas, atau gangguan koordinasi otot dasar panggul. Diagnosis disfungsi dasar panggul pascasalin sering terlewat karena ketiadaan alat skrining disfungsi dasar panggul khusus kehamilan. Evaluasi klinis dan diagnosis paling utama didasari pada gejala yang dilaporkan pasien. Evaluasi klinis mencakup empat domain penilaian yaitu terkait fungsi seksual, fungsi penyokong dasar panggul, fungsi urinasi, dan fungsi defekasi. Metode: merangkum berbagai referensi termutakhir yang dapat menjadi pedoman dan tata laksana disfungsi dasar panggul. Hasil: awal disfungsi dasar panggul pascasalin ditegakkan berdasarkan domain evaluasi klinis yang dikeluhkan oleh pasien. Tata laksana meliputi pertimbangan onset gejala, tidak menganggap normal suatu gejala yang mengganggu, tata laksana konservatif, pemantauan berkala, dan lanjutan. Latihan otot dasar panggul (Kegel) terbukti dapat mengidentifikasi dan menguatkan otot yang berkaitan dengan fungsi miksi, defekasi, dan seksual. Kesimpulan: Latihan Kegel dapat berperan sebagai tata laksana rutin mandiri pasien dengan disfungsi dasar panggul dengan gejala semua domain. Latihan ini dapat dikombinasikan dengan terapi biofeedback atau modalitas rehabilitasi yang lain.
Pola Kuman dan Kepekaan Antibiotik pada Kasus Infeksi Luka Operasi Obstetri
Authors:   KSM/ Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran/RSUP Dr. Hasan Sadikin Bandung, Irawan Iwan , Sukarsa M. Rizkar Arev , Aziz M. Alamsyah
Published: March 2022

Tujuan: Mengetahui karakteristik pasien infeksi luka operasi (ILO) bidang Obstetri dan mendeskripsikan gambaran pola kuman serta kepekaan antibiotiknya di Rumah Sakit Umum Pusat (RSUP) Dr. Hasan Sadikin Bandung Metode: Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan cross sectional yang bersifat retrospektif dari rekam medis pasien obstetri yang terdiagnosis infeksi luka operasi di RSUP Dr. Hasan Sadikin Bandung selama periode Juli 2020 - Juni 2021. Karakteristik subjek meliputi usia, berat badan, tinggi badan, body mass index (BMI), dan paritas. Dalam penelitian ini digunakan tingkat ketelitian (α) 5%, tingkat kepercayaan 95% sehingga diperoleh nilai Z = 1,96. Deskripsi karakteristik dan status pasien ditampilkan dalam bentuk tabel. Data kategorik dideskripsikan dengan jumlah (n) dan persentase (%). Hasil: Hasil penelusuran rekam medis didapatkan sebanyak 20 pasien yang didiagnosis dengan ILO. Seluruh pasien yang mengalami ILO merupakan pasien pasca seksio sesarea. Tidak didapatkan perbedaan yang bermakna pada rerata umur, berat badan, tinggi badan, BMI, dan sebaran paritas. Kesimpulan: ILO pada bidang obstetri seluruhnya terjadi pasca seksio sesarea. Tidak didapatkan perbedaan bermakna pada karakteristik pasien yang mengalami ILO. Pola kuman yang paling sering dijumpai adalah Escherichia coli dan Acinetobacter baumannii. Antibiotik yang sensitif terhadap mayoritas sampel adalah tigecycline dan meropenem. Antibiotic Susceptibility and Microbial Pattern in Obstetric Surgrical Wound Infection Abstract Objective: To know the characteristics of surgical site infection (SSI) patients in obstetrics field and describing the microbial pattern and their antibiotic sensitivity at the Hasan Sadikin General Hospital Method: This study was a descriptive observational study with a retrospective cross sectional approach from the medical records of obstetric patients diagnosed with surgical wound infections at Dr. Hasan Sadikin Bandung during the period July 2020 - June 2021. Subject characteristics include age, weight, height, body mass index (BMI), and parity. In this study, the level of accuracy (α) 5%, 95% confidence level, so that the value of Z = 1.96 is obtained. Results: The results gained from tracing medical records and obtained as many as 20 patients diagnosed with SSI. All patients who experienced SSI were post-cesarean section patients. There were no significant differences in the mean age, weight, height, BMI, and parity distribution. Conclusion: There was a high prevalence of female sexual dysfunction among health practitioners at Hasan Sadikin General Hospital, accounting to 41.8%. There was no statistically significant difference between various demographic aspects and female sexual dysfunction. Key words: Microbial pattern, antibiotic, sensitivity, surgical site infection
Hubungan Luaran Maternal dan Perinatal Terhadap Tingkat Keparahan Infeksi COVID-19
Authors:   Departemen Obstetri & Ginekologi Fakultas Kedokteran Univesitas Padjajaran RSUP Dr. Hasan Sadikin Bandung, Fitraendi FM. Dicky , Hidayat Dini , Pramatirta Akhmad Yogi
Published: March 2022

Tujuan: Penelitian ini dilakukan untuk mengetahui hubungan luaran maternal dan perinatal terhadap tingkat keparahan infeksi COVID-19 pada ibu bersalin di RSUP Dr. Hasan Sadikin Bandung. Metode: Penelitian ini menggunakan studi analitik observasional retrospektif dengan rancangan potong lintang menggunakan data rekam medik selama periode Maret 2020 hingga Juni 2021. Karakteristik subjek meliputi usia ibu, jumlah paritas, tingkat pendidikan, dan usia kehamilan. Luaran maternal meliputi hipertensi pada kehamilan, ketuban pecah dini, dan kejadian persalinan prematur. Hasil: Tidak ditemukan hubungan yang signifikan pada angka kejadian ketuban pecah dini (p-value 0,128) dan persalinan prematur (p-value 0,324) terhadap tingkat keparahan infeksi COVID-19. Pada ibu dengan infeksi COVID-19 derajat ringan memiliki luaran perinatal asfiksia ringan sebanyak 132 bayi (89,3%), asfiksia sedang 43 bayi (32,6%) dan asfiksia berat 5 bayi (3,8%). Terdapat hubungan bermakna antara derajat asfiksia pada janin dengan tingkat keparahan infeksi COVID-19 (p-value 0,013). Kesimpulan: Terdapat hubungan bermakna antara kejadian hipertensi dalam kehamilan dan tingkat mortalitas ibu terhadap tingkat keparahan infeksi COVID-19. Derajat asfiksia pada bayi baru lahir memiliki hubungan yang signifikan dengan tingkat keparahan infeksi COVID-19. Correlation Of Maternal And Perinatal Outcomes with the Severity Of Covid-19 Infection Abstract Objective: This study was conducted to evaluate the relationship between maternal and perinatal outcomes with the severity of COVID-19 infection in women giving birth at Dr. Hasan Sadikin Bandung Methods: This study was a retrospective observational analytical study with a cross-sectional design that used medical record data between March 2020 to June 2021. Subject characteristics include maternal age, parity, education level, and gestational age. Maternal outcomes consist of hypertension in pregnancy, premature rupture of membranes, and the incidence of preterm labor. Results: There was no significant relationship between the incidence of premature rupture of membranes (p-value 0.128) and preterm delivery (p-value 0.324) on the severity of COVID-19 infection. Mothers with mild COVID-19 infection had mild asphyxia perinatal outcomes as many as 132 infants (89.3%), moderate asphyxia in 43 infants (32.6%), and severe asphyxia in 5 infants (3.8%). There is a significant relationship between the degree of asphyxia in the fetus and the severity of COVID-19 infection (p-value 0.013). Conclusion: There is a significant relationship between the incidence of hypertension in pregnancy and maternal mortality with the severity of COVID-19 infection. The degree of asphyxia in newborns has a significant relationship with the severity of COVID-19 infection. Key words: Maternal outcome, perinatal, severity, COVID-19 infection
Neutrophil-Lymphocyte Ratio(NLR), Platelet-Lymphocyte Ratio (PLR) and D-Dimer to Length of Stay in ICU of Pregnancy with Covid 19 Complicating Severe Coagulopathy
Authors:   Department of Obstetrics and Gynecology, Faculty of Medicine Diponegoro University Kariadi General Hospital, Marpaung Mona Galatia , Syoufana Rizky Syahriar , Aulia Radith , Dewantiningrum Julian
Published: March 2022

Objective: The aim of this study was to obtain data that D-Dimer levels, Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) as a prognostic factors of length of stay in ICU. The longer length of stay in the Intensive Care Unit (ICU) as an indicator of severe coagulopathy. Methods :This study uses an analytic observational study with a cross sectional approach to analyze NLR , PLR ,and the D-Dimer levels and their relationship to length of stay in ICU of pregnant women with COVID-19 infection who were treated at RSUP Dr. Kariadi during March 2020 to October 2021. Medical records of patients with pregnancy confirmed COVID-19 who were diagnosed by PCR (polymerase chain reaction) and treated at Dr Kariadi Hospital between March 2020 and October 2021 were reviewed. Inclusion criteria were confirmed COVID 19 pregnant patient who treated in ICU isolation ward, aterm pregnancies, completed laboratory examinations, and subjects would be excluded if did not met inclusion criteria. p value <0.05 considered significant. Results: The mean value of D-Dimer was 3746.6 ± 4852.33 (460-20) ug/L, NLR was 8.14 ± 6.35 (2.20-29.60), PLR was 27.66 ± 20.60 (6.80-96.66). 15 were treated in ICU with Length of stay 0.3 ± 0.46 (0-1) with the significancy was NLR p 0.008, PLR p 0.073 and D-dimer p 0.225. Conclusion : High NLR, PLR and D-dimer levels correlated with severe coagulopathy that effect the length of stay in ICU. Neutrophyl-Lymphocyte Ratio (NLR) , Platelet-Lymphocyte Ratio (PLR) dan D-dimer Terhadap Lama Rawat Inap di ICU pada Kehamilan dengan COVID-19 yang Mengalami Koagulopati Berat Abstrak Tujuan: Tujuan dari studi ini untuk menilai jumlah D-Dimer , Neutrophyl-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) sebagai factor prognostic dari lama rawat inap di ICU. Metode: Studi ini menggunakan desain analitik observasional dengan pendekatan cross sectional untuk menganalisa NLR, PLR dan jumlah D Dimer dan hubungannya dengan lama rawat inap di ICU dari Wanita hamil dengan infeksi COVID 19 yang dirawat di RSUP Dr Kariadi selama bulan Maret 2020 hingga Oktober 202, nilai p <0.05 dianggap signifikan. Hasil: Rerata nilai D Dimer dari subjek ialah 3746,6 ± 4852.33 (460-20) ug/L, NLR 8.14 ± 6.35 (2.20-29.60), PLR 27.66 ± 20.60 (6.80-96.66). 15 pasien dirawat di ICU dengan lama rawat inap 0.3 ± 0.46 (0-1) dengan nilai signifikansi dari NLR p 0.008, PLR p 0.073 dan D-dimer p 0.225. Kesimpulan: NLR dan D dimer yang tinggi berhubungan dengan keparahan koagulopati yang menyebabkan lama rawat inap di ICU. Kata kunci : Lama rawat inap ICU, koagulopati, kehamilan dengan COVID 19
Fetal Programming pada Gangguan Mental Emosional: Tantangan Generasi Emas 2045
Authors:   KSM/ Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran/RSUP Dr. Hasan Sadikin Bandung, C. Mose Johanes
Published: March 2022

Pada hari-hari terakhir ini media sosial kita dibanjiri oleh banyak berita tentang pelbagai tindakan kekerasan baik verbal maupun fisik yang membuat kegaduhan dan kecemasan, baik di ruang publik antar anggota masyarakat, diruang privat instansi swasta atau pemerintah, maupun antar elit masyarakat. Fenomena ini menjurus pada pembenaran hipotesis tentang ‘masyarakat kita sedang sakit’. Hal ini sejalan dengan data Profil Kesehatan Indonesia Tahun 2020 yang di sampaikan oleh Kementrian Kesehatan RI 2021, yaitu tentang ‘Gangguan Mental Emosional’. Kelainan ini adalah suatu kondisi yang mengindikasikan seseorang mengalami perubahan psikologis yang mungkin merupakan sebuah kondisi normal, tetapi dapat juga merupakan kondisi patologis. Berdasarkan laporan hasil Riskesdas 2018 diketahui prevalensi gangguan mental emosional pada penduduk Indonesia sebesar 9,8%. Hal tersebut menunjukkan masih tingginya masalah gangguan mental emosional di Indonesia.
Tiga Kasus Holoprosensefal Alobar Dengan Variasi Gambaran Klinis : Diagnosis Ultrasonografi
Authors:   Maternal Fetal Division, Faculty of Medicine, Hasanuddin University Dr. Wahidin Sudirohusodo General Hospital Makassar, Riu Deviana Soraya , Lukas Efendi
Published: March 2022

Holoprosensefal (HPE) adalah spektrum malformasi dengan berbagai hasil luaran. Laporan ini menjelaskan 3 kasus holoprosensefal alobar yang dikonfirmasi saat antenatal dengan pemeriksaan ultrasonografi (USG). Selain gambaran holoprosensefal alobar yang serupa pada ketiga kasus, ditemukan gambaran lain yaitu probosis, siklops, kelainan jantung, dan arteri umbilikalis tunggal. Gambaran klinis yang berbeda adalah preeklamsia, polidaktili, dan mikropenis pada kasus pertama, pada kasus kedua adalah mielomeningokel; dan hidransefal untuk kasus ketiga. Analisis kromosom dilakukan hanya pada kasus kedua dengan hasil berupa translokasi kromosom 3 ke 9 (46 XX, der (9) t(3:9)(p21:q33). Pencitraan menggunakan USG adalah modalitas yang bermanfaat untuk mendeteksi holoprosensefal alobar. Bila skrining dilakukan pada masa usia kehamilan yang tepat maka dapat ditemukan kelainan kongenital mayor letal secara dini, sehingga terminasi kehamilan lebih mudah dengan komplikasi yang lebih minimal. Three Cases Of Holoprosencephalic Alobar With A Variety Of Clinical Features: Ultrasound Diagnostic Abstract Holoprosencephaly (HPE) is a spectrum of malformations with various outcomes and the most common congenital brain disorder. This report describes 3 cases of alobar holoprosencephaly that were confirmed antenatally by ultrasound examination. Apart from the similar appearance of alobar holoprosencephaly in all three cases, other similar characteristics were proboscis, cyclopia, heart defects, and a single umbilical artery. The different clinical features were maternal preeclampsia, polydactyly, and micropenis in the first case. The different clinical feature in the second case was myelomeningocele; and hydranencephaly for the third case. Chromosome analysis was performed only in the second case with results in the form of translocation of chromosomes 3 to 9 (46 XX, der (9) t(3: 9)(p21: q33). If the chromosome analysis is limited, ultrasound imaging is beneficial for detecting alobar holoprosencephaly. Key words: alobar holoprosencephaly, myelomeningocele, hydranencephaly, preeclampsia
Videogame as Means of Communication and Education: Philosophical Analysis
Authors: OGNEVIUK Viktor , MALETSKA Mariia , VINNIKOVA Nataliia , ZAVADSKYI Vitaliy
Published: March 2022

The study is devoted to the philosophical consideration of specific features of communication and education through the use of video games. The purpose of the research was to consider the specific features of communication in the process of interaction within video games, to reveal their educational potential and the difference in their use for educational purposes. The analysis of videogame definitions has allowed focusing on their specific features, namely: interactive, rule-based nature and the need of the specific hardware. As a result, the possible types of dialogue within video games have been considered and, on their basis, the main types of interaction have been formulated for analyzing their use in education: interaction with no active player, player-videogame interaction in case of one-player videogames, player-videogame-player interaction and player-community-videogame interaction. In conclusion, the similarity of videogame playing and the learning process has been delineated in relation to the analyzed types of interaction. The authors state the further need for a comprehensive study of the specific features of each of described types due to the significant differences in the dialogue and educational potential of videogames belonging to them.
Knowledge, attitudes and behavioural intentions regarding organ donation in a General Hospital of Northern Greece
Authors: Alibaki Chrysi Alibaki , Apostolakis Ioannis , Domeyer Philip-Richard , Sarafis Pavlos
Published: March 2022

Introduction: Organ donation is considered in many cases as the only therapeutic solution. The lack of donors throughout the world, leads to the need of a survey of the factors affecting the formation of the human behavior in order to change it, in particular in our country, where there is a significant research gap and a reduced number of donors.
Aim: The aim of the specific quantitative survey is the detection of the factors affecting the attitude and perceptions of the nursing and medical staff of the General Hospital (G.H.) of Edessa, with regards to organ donation, as well as the prediction of their willingness to issue an organ donor card.
Methods: The survey was based on the collection of 283 questionnaires, based on the Theory of Planned Behavior. In order to enhance the representation amongst people, data were weighted so that both doctors and nurses could have equal rates to such of the population.
Results: The intention to discuss with the family was positively associated with moral rules, while the intention to issue a donor card was positively associated with morality and subjective perception of control. Gender, profession, educational level and previous relevant behavior are the most important factors of differentiation.
Conclusions: The medical and nursing staff of the G.H. of Edessa presents a low intention to issue a donation card, however, they are very positive to the idea of donation. The attitude and intention of the medical doctors is more positive comparison to the nursing. The professional status is the most important variable under study, as it differentiates attitudes and intentions of health care workers. It is necessary to promote the idea of donation through social services.
Sunitinib potentiates the cytotoxic effect of electrochemotherapy in pancreatic carcinoma cells
Authors: Bosnjak Masa , Jesenko Tanja , Markelc Bostjan , Cerovsek Anja , Sersa Gregor , Cemazar Maja
Published: March 2022

Background

One of the new treatment options for unresectable locally advanced pancreatic cancer is electrochemotherapy (ECT), a local ablative therapy that potentiates the entry of chemotherapeutic drugs into the cells, by the application of an electric field to the tumor. Its feasibility and safety were demonstrated in preclinical and clinical studies; however, there is a lack of preclinical studies assessing the actions of different drugs used in ECT, their mechanisms and interactions with other target drugs that are used in clinical practice.

Materials and methods

The aim of the study was to determine the cytotoxicity of two chemotherapeutic drugs usually used in ECT (bleomycin and cisplatin) in the BxPC-3 human pancreatic carcinoma cell line and evaluate the interactions of ECT with the targeted drug sunitinib. First, the cytotoxicity of ECT using both chemotherapeutics was determined. In the next part, the interactions of ECT and sunitinib were evaluated through determination of combined cytotoxicity, sunitinib targets and kinetics of cell death.

Results

The results demonstrate that ECT is effective in pancreatic cancer cell line, especially when bleomycin is used, with the onset of cell death in the first hours after the treatment, reaching a plateau at 20 hours after the treatment. Furthermore, we provide the rationale for combining ECT with bleomycin and the targeted drug sunitinib to potentiate cytotoxicity. The combined treatment of sunitinib and ECT was synergistic for bleomycin only at the highest used concentration of bleomycin 0.14 μM, whereas with lower doses of bleomycin, this effect was not observed. The interaction of ECT and treatment with sunitinib was confirmed by course of the cell death, also indicating on synergism.

Conclusions

ECT and sunitinib combined treatment has clinical potential, and further studies are warranted.
Ser mujer española en el Siglo de Oro y la época
franquista: una identidad apolillada en
La perfecta casada de Fray Luis de León
y Cinco horas con Mario de Miguel Delibes
Authors: KOUADIO Djoko Luis Stéphane , KANGA Akissi Agnès Danielle
Published: March 2022

Discrimination, be it wage discrimination, race and above all gender inequality, is an
ancient phenomenon that continues to transcend eras and societies. Spanish women are
unable to escape this reality as attested in the writings of Golden Century: era Augustinian
monk Fray Luis de León and 20th century novelist Miguel Delibes. The moralistic treatise
La perfecta casada by Fray Luis focuses on the description of the good woman who obeys her
husband without being able to complain or oppose him by manifesting her own free will. As
for the social novel Cinco horas con Mario, the reader realises that it exposes the features of
a society that marginalises women and, paradoxically, reveals attempts at rebellion through
the female character shaped by the Francoist system.
Le langage des jeunes : moteur de discrimination
ou marque d’identité ?
Authors: CONSTANTINOU Georgie
Published: March 2022

Young people in the suburbs need to create their own language to symbolically resist the
exclusionary relationships maintained against them (social violence, discrimination,
racism, exclusion). In addition, we can understand that young people from socioeconomically disadvantaged classes can find in a specific language a way to separate from
their place of residence, to belong to a group and thus obtain a positive social identity.
There is a group of people who believe that this language is a mark of identity, but there are
other people who believe that this language is a driving force of discrimination. What is the
relationship between this language of young people and the feeling of exclusion; how young
people, through their codified language, challenge and experience this exclusion.
Ensuring environmental safety through the reuse of anti-icing friction materials
Authors: Makejeva Daria , Kralin Andrey
Published: March 2022

В статье ставятся вопросы повышения уровня экологической безопасности городского хозяйства и рационального ресурсопотребления. Рассматривается возможность повторного использования противогололёдных фрикционных материалов, обосновывается актуальность и приводятся результаты исследования способов классификации сыпучих материалов, анализа способов обогащения с возможностью его вторичного применения в качестве противогололёдных материалов (ПГМ). Объектом исследования являются процессы, связанные с возможностью вторичного применения ПГМ, предметом – сыпучий материал, применяемый в качестве средства борьбы со скользкостью.
Up-to-date tools for non-explosive mining of thin ore veins and methods for improving the efficiency of drilling equipment
Authors: Belan Bogdan , Zhilin Sergey , Komarov Oleg , Cheban Anton
Published: March 2022

Показаны современные способы ведения безвзрывной (механической) добычи твердых полезных ископаемых и основные виды бурового вооружения для ведения механической добычи и выемки горной породы. Рассмотрены перспективы улучшения буровых установок и карьерных комбайнов, а также упомянута возможность применения автоматизированной техники при добыче полезных ископаемых. Анализом методов повышения энерго- и ресурсоэффективности бурового вооружения выявлена проблема малой эффективности и высокой стоимости различных процессов армирования. Определен и проанализирован перспективный метод армирования бурового вооружения.
Small-sized underwater object’s detection and its radial velocity and range estimation based on discrete-coded frequency-modulated signal sequence
Authors: Shostak Sergey , Bengard Alexander
Published: March 2022

В гидроакустике важное значение имеют гидролокация и оценка радиальной скорости подводного объекта. Сфера их применения различна – от оценки скорости морских млекопитающих до охраны морских инженерных сооружений. Проблема оценки дальности и радиальной скорости в гидроакустике актуальна и по сей день, поэтому в данной статье описан метод, с помощью которого можно определить данные параметры подводного объекта.
Development trends in marine production platform fleet in 2015–2021
Authors:   Krylov State Research Centre, St. Petersburg, Russia, Berezhnoy K. ,   St. Petersburg State Marine Technical University, Russia, Verbitsky S. ,   Krylov State Research Centre, St. Petersburg, Russia,   St. Petersburg State Marine Technical University, Russia
Published: March 2022

Object and purpose of research. This paper discusses marine oil and gas production platforms splitted into four types depending on their purpose. The study was intended to analyse the changes in global production platform fleet and outline the main trends in its development. Materials and methods. The study was based on the open-access data available with offshore field developers, oil and gas companies, shipyards and design offices. The methods in this study were acquisition, analysis and comparison of the data about the fleet of marine oil and gas production platforms. Main results. The paper presents the results of fleet composition analysis for floating oil and gas production platforms over the period of 2015–2021 characterized by the decline in global oil and gas prices. The study shows that the most common type of marine production platforms is FPSO (213 vessels). The strength of FPU and FPDSO fleets remains the same: 99 and 2 vessels respectively. Their geography has not changed either. The fleet of FLNGs has increased up to 7 ships since the commissioning of first FLNGs in 2014. Conclusion. FPSO platforms of various designs (mostly ship-type) offer high mobility and operational flexibility, i.e. greater project revenues and zero pipeline construction costs in case of remote field developments. It must be noted that water depths at FPSO locations have reached their record highs: 2900 m for production platforms and 3400 m for drilling ones. In future, floating platforms could be replaced by subsea production system but their massive introduction cannot be expected in at least 30–50 years to come.
Inovasi Sistem Informasi Pendaftaran Pasien Dengan Scanner Kib Dan Mesin Antrian Elektronik
Authors: Maulana Moh.
Published: March 2022

Registration system at the Banjarsengon Community Health Center is still done manually starting from calling the queue number to the making of the MNH. Such a system would cause the patient registration process to be ineffective in terms of time while in the manufacture of MNH using paper material, it would not be durable or could be said to be damaged so that the writing could not be read. In addition, in looking for data on old patient visits, officers must search individual patients' names in the thick registration book. The purpose of this study is that all of the problems previously described can be resolved. The technology used in making the KIB scanner and the queue number uses RFID and sevent segment which is controlled by an Arduino microcontroller. Making the patient registration information system application using Microsoft Visual Studio 17. The results of this study are the patient registration information system with the MNH scanner and electronic queuing machine that can facilitate the registration officer in serving patients.
Sistem Informasi Pelaporan Status Gizi Balita Berbasis Web di Puskesmas Banjarsengon
Authors: Sholehah Firdaus
Published: March 2022

Recording and reporting nutritional status at the Banjarsengon Community Health Center is still manual and uses Excel. The report also includes the process of determining or calculating the nutritional status of children under five. The use of Excel has many limitations such as the absence of a password for toddlers data security, the process of rearranging the Excel sheet for printing and so on. The purpose of this study was to design and create a web-based nutritional status reporting information system for children under five in the Banjarsengon Health Center using the waterfall method. Data collection is done by interview, observation, and documentation. The results of this study are web-based nutritional status reporting information systems with several advantages, in addition to focusing on calculating the nutritional status of children under five, this information system can also make detailed nutritional status reports for toddlers. The detailed report in question is a toddler report which is grouped based on nutritional problems experienced by toddlers and their solutions. This information system is expected to make it easier for nutrition workers at the Banjarsengon Health Center to carry out their duties.
Evaluasi Sistem Penomoran Rekam Medis Menggunakan Metode Focus PDCA di RSUP Sanglah
Authors: Pinerdi Sedyo , Deharja Atma , Rachmawati Ervina
Published: March 2022

The duplication of medical record numbers during February 2020 at Sanglah Hospital reachs 7 cases, it iscaused by the mistake of the officer register patients at SIMARS and the handling of duplicate cases that doesnot optimal. The purpose of this study was evaluated the patient's medical record numbering system used theFOCUS PDCA method at Sanglah Hospital. This type of the study is qualitative. The data collecting methodused in this study were observation and interviews. The data analysis stage in this research included aninvestigation stage to find, organized, clarify, understand, select, plan, do, check, dan action. The results ofthis study were duplicate cases that occur because patients were uncooperative when discussed with officers,patient did not register, officers were not thorough, authentication systems for patient search menu was notintegrated, the absence of regulations regarding the handling of cases of duplicate medical record numbers,and duplicate case reporting only limited to merge medical record files. The solutions chosen to solve theproblem were developing SIMARS registration menu, making SOP for handling duplicate cases of SanglahHospital medical records, and making menu recording and reporting of duplicate medical record numbercases in E-PASTI.The planning done is an analys of the needs of emergency room registration officers,discussion of SOP design for handling duplicate medical record number cases, and analys the staff's needsfor the development of E-PASTI that results. The next stage is to give an advice in the IT field to developSIMARS in the patient registration search menu, request SOP authorization for the handling of duplicatemedical record number cases for the head of the medical record, and implement the menu recording andreporting of duplicate medical record number case cases.
Analisis Faktor Penyebab Keterlambatan Pengembalian Berkas Rekam Medis Rawat Jalan di RSUPN Dr. Cipto Mangunkusumo
Authors: Dilla Rizky Farah , Mudiono Demiawan Rachmatta Putro , Alfiansyah Gamasiano
Published: March 2022

Keterlambatan pengembalian berkas rekam medis dapat mempengaruhi pelayanan rekam medis dan akan menghambat kegiatan selanjutnya, seperti kegiatan assembling, koding, analisis, indeks. Pengembalian berkas rekam medis rawat jalan di RSUPN Dr. Cipto Mangunkusumo masih mengalami keterlambatan. Pada bulan januari sampai dengan februari total berkas rekam medis rawat jalan yang terlambat sebanyak 282 berkas (0,016%) dari 17.616 berkas. Tujuan dari penelitian adalah menganalisis faktorÂ  penyebab keterlambatan pengembalian berkas rekam medis rawat jalan di RSUPN Dr. Cipto Mangunkusumo. Jenis penelitian yang digunakan adalah kualitatif. Teknik pengumpulan data berupa wawancara dan observasi. Subjek penelitian ini adalah Kepala Rekam Medis, Petugas Penanggung Jawab Operasional Unit Rekam Medis, Petugas Filling, Petugas Pengembalian Berkas. Penelitian Â dilakukan pada bulan februari sampai bulan maret 2020. Hasil dari penelitian yang didapatkan yaitu pengetahuan dan sikap beberapa petugas masih belum paham dengan SOP pengembalian berkas rekam medis dan kepatuhan sikap petugas pengembalian masih kurang baik. Sarana dan prasarana sudah mendukung, hanya kurangnya ketelitian pada sumber daya petugas pengembalian. Sudah diberikan motivasi oleh koordinator pelayanan Unit Rekam Medis, dan sudah terdapat (SOP) pengembalian berkas rekam medis. Upaya yang dilakukan adalah memberi tahu perawat tentang batas waktu pengembalian berkas rekam medis rawat jalan, kepala rekam medis memberi teguran kepada perawat yang terlambat mengembalikan berkas rekam medis, memberikan motivasi kerja dan sering melakukan sosialisasi SOP terkait pengembalian berkas rekam medis rawat jalan.
Analisis Penyebab Lama Penyediaan Berkas Rekam Medis Rawat Jalan di Puskesmas Mangaran
Authors: Herman Lutfiatun Nadibah , Wijayanti Rossalina Adi , Deharja Atma , Roziqin Mochammad Choirur
Published: March 2022

The provision of long-term patient outpatient medical record files in Mangaran Public Health Center is one type of service provided to patients. Based on pre-research survey, it known that the time for providing the medical record files that exceed the established standards is 17.70%. This researched aim is to analyze the caused factors of the long duration for supplying medical file records of long-term patient based on individual and situational factors which will the priority causes of the main problems using the Reinke method. This research is qualitative research. The results showed that long waited for supplying medical record files of long-term patient is the searching process of the medical file records that takes a long time due to the attitude of the officer while handling misfile is not optimal, there is no training related to the medical records, less detailed SOP registration does not contain the standard time to provide the medical file records and the absence of SOP to return the medical records, and also the computers that often error and unavailability of tracers in the storage room. In response to those factors, it is necessary to make an improvement and socialization about the registration SOP’s, requesting propose of the medical record file map/folders and the use of tracers, and also held a training specifically about the medical file records at least 2 or 3 times a year and also doing the computer maintenance at least once a month.
Desain Rak Penyimpanan Berkas Rekam Medis di Rumah Sakit Universitas Airlangga Surabaya
Authors: Rahmania Day , Wicaksono Andri Permana , Nuraini Novita
Published: March 2022

Filling room has an important role in maintaining medical records, especially in terms of storage and protection of medical records. The creation of officers ease in taking and storing medical records in supported by the existence of an ergonomic storage space that is adapted to the anthropometric aspects. The design of the storage rack in accordance with the anthropometric data of the officer can facilitate the work of the officers. Storage racks at Airlangga University Hospital are not in accordance with the anthropometry of the officers, resulting in work discomfort and fatigue. The purpose of this study was to analyze the ergonomics aspects of the storage rack based on the anthropometry of the filling officer. This type of research is descriptive and data collection is done by observation. The population of this study was 5 filing officers. The results of this study indicate that the condition of the storage rack in the filling room of the Airlangga University Hospital is not in accordance of the filling officer. The anthropometry of the filling officer used in designing the rack, namely the reach of the hand up to 202 cm, is used to measure the height of the medical record file storage rack, data fathom length 162 cm is used to reference the length of the medical records file storage rack and shoulder width data used to reference the distance between medical record file storage rack.
Evaluasi Kejadian Missfile Rekam Medis menggunakan Metode Focus PDCA di RSUP Sanglah
Authors: Salim Fahirah Tamara , Deharja Atma , Rachmawati Ervina
Published: March 2022

There were 482 medical file missfile incidents in 2019, with the highest number occurring in June 2019 with 61 medical record misfile, this could cause officers to experience difficulties in searching for medical record files and increasing the work of officers to more busy because they have to do a search on other number shelves that allow it to be misplaced, so the service process tends longer. This research aims to evaluate the event of medical record misfile using the FOCUS PDCA method at Sanglah Hospital Denpasar. Data collection techniques used in this research were interviews and observation. The data analysis stage in this research includes the identification of stage of find, organized, clarify, understand, select, plan, do, check, and action. The solution chosen to solve the problem is by designing the media information about the range of medical record storage on each shelf, carrying out the process of attached numbering information media to each storage shelf, and conducting information dissemination related to the attached media. The results of this evaluation are storing medical record files that are arranged according to the number on the shelf and re-monitoring at the end of every month all medical records in the place.
Textile solid waste in product development studies
Authors:   Asian Institute of Fashion Design, Iqra University, Karachi, Pakistan, Uddin Faheem , Umer Komal ,   Asian Institute of Fashion Design, Iqra University, Karachi, Pakistan, Anjum Syeda Tehniyat ,   Asian Institute of Fashion Design, Iqra University, Karachi, Pakistan
Published: March 2022

Textile solid waste disposal and utilization is currently an important concern worldwide. Fashion and traditional articles of textiles are sourcing the solid textile waste generation. An increasing population and consumption of fiber and textile articles emphasize the development studies for the re-use of solid textile waste. Production of textiles is accompanied by the release of volatile emission and effluent during processing, and disposal of fibrous articles are producing solid waste. The hazardous waste generated from the textile can be seen as pre- consumer solid waste (fiber, yarn, and fabric pieces), processing waste (volatiles, chemicals and effluent release during the process), and post- consumer waste (textile fabric, yarn, apparel, home textiles, technical textiles, etc.) dispose to environment following the service life. Therefore, re-using the fiber and textile articles can significantly reduce undesired effects to environment. Designing the products using solid textile waste can be a useful source for reducing the environmental hazard. This study describes the re-use of various fiber and textiles, though the case studies, particularly denim fabric, in designing the products for home decoration.
COM AS MÃOS NA TERRA: ESTRATÉGIAS DE PROMOÇÃO EM NUTRIÇÃO AGROECOLÓGICA
Authors: Vasconcelos Carliane Vanessa Souza , Lima Maria Raquel da Silva , Vasconcelos Lizandra Tereza de Souza
Published: March 2022

Este estudo trata-se de um relato de experiência, que objetiva mostrar uma intervenção para a melhoria do acesso a alimentos saudáveis de famílias, em um Bairro da periferia urbana do Município de Sobral-Ceará através de hortas comunitárias, orgânicas e sustentáveis como estratégia de promover Educação Alimentar e Nutricional. A intervenção incluiu 15 pessoas de famílias beneficiárias do Programa Bolsa Família.  Foram realizados quatro encontros educativos sobre alimentação saudável com enfoque na inclusão de frutas, legumes e verduras. Além, do manejo de hortas para o cultivo do próprio alimento. O momento foi oportuno para os participantes aprenderam a preparar a terra, a semear, plantar, regar, colher, e receber informações nutricionais. Diante do que foi vivenciado, a pesquisa promoveu reflexão crítica sobre a segurança alimentar e nutricional e ressaltou a importância de se cultivar o próprio alimento para torna-lo acessível.