bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Feasibility Evaluation of Smart Cancer Care 2.0 Based on Patient-Reported Outcomes for Post-Discharge Management of Patients with Cancer
Authors: Kwon Jin Ah , Yang Songsoo , Koh Su-Jin , Noh Young Ju , Kang Dong Yoon , Yang Sol Bin , Kwon Eun Ji , Seo Jeong-Wook , Kim Jin sung , Ock Minsu
Published: April 2024

Purpose A “Smart Cancer Care” platform that integrates patient-reported outcomes (PROs) with management has been established in Korea. This study focused on improving health behaviors and connecting patients to welfare services by introducing and assessing the feasibility of “Smart Cancer Care 2.0,” an enhanced version designed for monitoring complications post-cancer treatment.Materials and Methods Smart Cancer Care 2.0 was developed by conducting a literature review and consulting with expert panels to identify symptoms or variables requiring monitoring and management guidelines based on the treatment type. Qualitative and quantitative surveys were conducted to assess the feasibility of the app and web system based on the experiences of patients with cancer and healthcare workers.Results A total of 81 symptoms or variables (chemotherapy-, surgery-, radiotherapy-, rehabilitation-, and health management-related) were selected for management in Smart Cancer Care 2.0. PROs for these symptoms were basically categorized into three severity grades: preventive management, self-treatment, and consultation with a healthcare worker or visit to a healthcare institution. The overall mean scores in the feasibility evaluation by patients and healthcare workers were 3.83 and 3.90 points, respectively, indicating high usefulness.Conclusion Smart Cancer Care 2.0 leverages the existing information and communication technologies–based platform, Smart Cancer Care, and further includes health behaviors and welfare services. Smart Cancer Care 2.0 may play a crucial role in establishing a comprehensive post-discharge management system for patients with cancer as it provides suitable interventions based on patients’ responses and allows the regularly collected PROs to be easily viewed for streamlined care.
Prognostic Significance of Bulky Nodal Disease in Anal Cancer Management: A Multi-institutional Study
Authors: Chun Seok-Joo , Kim Eunji , Jang Won Il , Kim Mi-Sook , Kang Hyun-Cheol , Kim Byoung Hyuck , Chie Eui Kyu
Published: April 2024

Purpose This study aimed to assess the prognostic significance of bulky nodal involvement in patients with anal squamous cell carcinoma treated with definitive chemoradiotherapy.Materials and Methods We retrospectively analyzed medical records of patients diagnosed with anal squamous cell carcinoma who underwent definitive chemoradiotherapy at three medical centers between 2004 and 2021. Exclusion criteria included distant metastasis at diagnosis, 2D radiotherapy, and salvage treatment for local relapse. Bulky N+ was defined as nodes with a long diameter of 2 cm or greater.Results A total of 104 patients were included, comprising 51 with N0, 46 with non-bulky N+, and seven with bulky N+. The median follow-up duration was 54.0 months (range, 6.4 to 162.2 months). Estimated 5-year progression-free survival (PFS), loco-regional recurrence-free survival (LRRFS), and overall survival (OS) rates for patients with bulky N+ were 42.9%, 42.9%, and 47.6%, respectively. Bulky N+ was significantly associated with inferior PFS, LRRFS, and OS compared to patients without or with non-bulky N+, even after multivariate analysis. We proposed a new staging system incorporating bulky N+ as N2 category, with estimated 5-year LRRFS, PFS, and OS rates of 81.1%, 80.6%, and 86.2% for stage I, 67.7%, 60.9%, and 93.3% for stage II, and 42.9%, 42.9%, and 47.6% for stage III disease, enhancing the predictability of prognosis.Conclusion Patients with bulky nodal disease treated with standard chemoradiotherapy experienced poor survival outcomes, indicating the potential necessity for further treatment intensification.
Identification of New Pathogenic Variants of Hereditary Diffuse Gastric Cancer
Authors: Oh Seung-Young , Jang Giyong , Kim Jaeryuk , Jeong Kyoung-Yun , Kim Hyun Myong , Kwak Yoon Jin , Kong Seong-Ho , Park Do Joong , Lee Hyuk-Joon , Cho Sung-Yup , Kim Jong-Il , Yang Han-Kwang
Published: April 2024

Purpose Hereditary diffuse gastric cancer (HDGC) presents a significant genetic predisposition, notably linked to mutations in the CDH1 and CTNNA1. However, the genetic basis for over half of HDGC cases remains unidentified. The aim of this study is to identify novel pathogenic variants in HDGC and evaluate their protein expression.Materials and Methods Among 20 qualifying families, two were selected based on available pedigree and DNA. Whole genome sequencing (WGS) on DNA extracted from blood and whole exome sequencing on DNA from formalin-fixed paraffin-embedded tissues were performed to find potential pathogenic variants in HDGC. After selection of a candidate variant, functional validation, and enrichment analysis were performed.Results As a result of WGS, three candidate germline mutations (EPHA5, MCOA2, and RHOA) were identified in one family. After literature review and in-silico analyses, the RHOA mutation (R129W) was selected as a candidate. This mutation was found in two gastric cancer patients within the family. In functional validation, it showed RhoA overexpression and a higher GTP-bound state in the RhoaR129W mutant. Decreased phosphorylation at Ser127/397 suggested altered YAP1 regulation in the Rho-ROCK pathway. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses linked RhoaR129W overexpression to changed migration/adhesion in MKN1 cell line. However, this RHOA mutation (R129W) was not found in index patients in other families.Conclusion The RHOA mutation (R129W) emerges as a potential causative gene for HDGC, but only in one family, indicating a need for further studies to understand its role in HDGC pathogenesis fully.
Sarcopenia as a Robust Predictor of Readmission within 6 Months among Individuals Experiencing Acute Stroke
Authors: Abe Takafumi , Yoshimura Yoshihiro , Sato Yoichi , Nagano Fumihiko , Matsumoto Ayaka
Published: April 2024

Background: Sarcopenia negatively affects the short-term prognosis of hospitalized older adults. However, no evidence currently supports a direct relationship between sarcopenia and readmission among individuals who have experienced an acute stroke. Therefore, we investigated whether sarcopenia is associated with readmission after discharge.Methods: This retrospective cohort study included patients who had experienced acute stroke. Sarcopenia was defined as the coexistence of low skeletal muscle mass index (SMI) and grip strength. We applied the log-rank test and Cox proportional hazards regression analysis to analyze whether sarcopenia, low SMI, and low grip strength were associated with readmission within 6 months.Results: Among 228 included patients (mean age, 72.8 years; 146 males), the prevalence of sarcopenia was 24.6% (n=56; male 17.8%; female 36.6%). Cox proportional hazards regression analysis using the propensity score as a covariate revealed that sarcopenia (hazard ratio [HR]=7.21; 95% confidence interval [CI] 1.45–35.8; p=0.016) and low skeletal muscle mass (HR=7.40; 95% CI 1.14–48.1; p=0.036), but not low grip strength (HR=1.42; 95% CI 0.281–7.21; p=0.670), were significantly associated with readmission for stroke within 6 months.Conclusions: Sarcopenia was negatively associated with readmission within 6 months of stroke onset in patients in Japan who had experienced an acute stroke. These findings suggest that the identification of sarcopenia may facilitate prognostic prediction from the acute stage and intervention(s) to prevent rehospitalization.
Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome
Authors: Zhang Gu-Lao , Liu Yuan , Liu Yan-Feng , Huang Xian-Tao , Tao Yu , Chen Zhen-Huan , Lai Heng-Li
Published: April 2024

BACKGROUND

Diabetic cardiomyopathy (DCM), which is a complication of diabetes, poses a great threat to public health. Recent studies have confirmed the role of NLRP3 (NOD-like receptor protein 3) activation in DCM development through the inflammatory response. Teneligliptin is an oral hypoglycemic dipeptidyl peptidase-IV inhibitor used to treat diabetes. Teneligliptin has recently been reported to have anti-inflammatory and protective effects on myocardial cells.

AIM

To examine the therapeutic effects of teneligliptin on DCM in diabetic mice.

METHODS

Streptozotocin was administered to induce diabetes in mice, followed by treatment with 30 mg/kg teneligliptin.

RESULTS

Marked increases in cardiomyocyte area and cardiac hypertrophy indicator heart weight/tibia length reductions in fractional shortening, ejection fraction, and heart rate; increases in creatine kinase-MB (CK-MB), aspartate transaminase (AST), and lactate dehydrogenase (LDH) levels; and upregulated NADPH oxidase 4 were observed in diabetic mice, all of which were significantly reversed by teneligliptin. Moreover, NLRP3 inflammasome activation and increased release of interleukin-1β in diabetic mice were inhibited by teneligliptin. Primary mouse cardiomyocytes were treated with high glucose (30 mmol/L) with or without teneligliptin (2.5 or 5 µM) for 24 h. NLRP3 inflammasome activation. Increases in CK-MB, AST, and LDH levels in glucose-stimulated cardiomyocytes were markedly inhibited by teneligliptin, and AMP (p-adenosine 5‘-monophosphate)-p-AMPK (activated protein kinase) levels were increased. Furthermore, the beneficial effects of teneligliptin on hyperglycaemia-induced cardiomyocytes were abolished by the AMPK signaling inhibitor compound C.

CONCLUSION

Overall, teneligliptin mitigated DCM by mitigating activation of the NLRP3 inflammasome.
Icariin accelerates bone regeneration by inducing osteogenesis-angiogenesis coupling in rats with type 1 diabetes mellitus
Authors: Zheng Sheng , Hu Guan-Yu , Li Jun-Hua , Zheng Jia , Li Yi-Kai
Published: April 2024

BACKGROUND

Icariin (ICA), a natural flavonoid compound monomer, has multiple pharmacological activities. However, its effect on bone defect in the context of type 1 diabetes mellitus (T1DM) has not yet been examined.

AIM

To explore the role and potential mechanism of ICA on bone defect in the context of T1DM.

METHODS

The effects of ICA on osteogenesis and angiogenesis were evaluated by alkaline phosphatase staining, alizarin red S staining, quantitative real-time polymerase chain reaction, Western blot, and immunofluorescence. Angiogenesis-related assays were conducted to investigate the relationship between osteogenesis and angiogenesis. A bone defect model was established in T1DM rats. The model rats were then treated with ICA or placebo and micron-scale computed tomography, histomorphometry, histology, and sequential fluorescent labeling were used to evaluate the effect of ICA on bone formation in the defect area.

RESULTS

ICA promoted bone marrow mesenchymal stem cell (BMSC) proliferation and osteogenic differentiation. The ICA treated-BMSCs showed higher expression levels of osteogenesis-related markers (alkaline phosphatase and osteocalcin) and angiogenesis-related markers (vascular endothelial growth factor A and platelet endothelial cell adhesion molecule 1) compared to the untreated group. ICA was also found to induce osteogenesis-angiogenesis coupling of BMSCs. In the bone defect model T1DM rats, ICA facilitated bone formation and CD31hiEMCNhi type H-positive capillary formation. Lastly, ICA effectively accelerated the rate of bone formation in the defect area.

CONCLUSION

ICA was able to accelerate bone regeneration in a T1DM rat model by inducing osteogenesis-angiogenesis coupling of BMSCs.
Metabolic syndrome’s new therapy: Supplement the gut microbiome
Authors: Xu Yong-Wei , Tian Jun , Song Yan , Zhang Ba-Cui , Wang Jing
Published: April 2024

This letter to the editor discusses the publication on gut microbiome supplementation as therapy for metabolic syndrome. Gut microbiome dysbiosis disrupts intestinal bacterial homeostasis and is related to chronic inflammation, insulin resistance, cardiovascular diseases, type 2 diabetes mellitus, and obesity. Previous research has found that increasing the abundance of beneficial microbiota in the gut modulates metabolic syndrome by reducing chronic inflammation and insulin resistance. Prebiotics, probiotics, synbiotics, and postbiotics are often used as supplements to increase the number of beneficial microbes and thus the production of short-chain fatty acids, which have positive effects on the gut microbiome and metabolic syndrome. In this review article, the author summarizes the available supplements to increase the abundance of beneficial gut microbiota and reduce the abundance of harmful microbiota in patients with metabolic disorders. Our group is also researching the role of the gut microbiota in chronic liver disease. This article will be of great help to our research. At the end of the letter, the mechanism of the gut microbiota in chronic liver disease is discussed.
Long-term outcomes after endoscopic removal of malignant colorectal polyps: Results from a 10-year cohort
Authors: Fábián Anna , Bor Renáta , Vasas Béla , Szűcs Mónika , Tóth Tibor , Bősze Zsófia , Szántó Kata Judit , Bacsur Péter , Bálint Anita , Farkas Bernadett , Farkas Klaudia , Milassin Ágnes , Rutka Mariann , Resál Tamás , Molnár Tamás , Szepes Zoltán
Published: April 2024

BACKGROUND

Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging, and evidence regarding a surveillance-only strategy is limited.

AIM

To evaluate long-term outcomes after endoscopic removal of malignant colorectal polyps.

METHODS

A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and 2020. Residual disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were investigated. Event rates for categorical variables and means for continuous variables with 95% confidence intervals were calculated, and Fisher’s exact test and Mann-Whitney test were performed. Potential risk factors of adverse outcomes were determined with univariate and multivariate logistic regression models.

RESULTS

In total, 135 lesions (mean size: 22.1 mm; location: 42% rectal) from 129 patients (mean age: 67.7 years; 56% male) were enrolled. The proportion of pedunculated and non-pedunculated lesions was similar, with en bloc resection in 82% and 47% of lesions, respectively. Tumor differentiation, distance from resection margins, depth of submucosal invasion, lymphovascular invasion, and budding were reported at 89.6%, 45.2%, 58.5%, 31.9%, and 25.2%, respectively. Residual tumor was found in 10 patients, and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical resection. Univariate analysis identified piecemeal resection as a risk factor for residual malignancy (odds ratio: 1.74; P = 0.042). At least 1 year of follow-up was available for 117 lesions from 111 patients (mean follow-up period: 5.59 years). Overall, 54%, 30%, 30%, 11%, and 16% of patients presented at the 1-year, 3-year, 5-year, 7-year, and 9-10-year surveillance examinations. Adverse outcomes occurred in 9.0% (local recurrence and dissemination in 4 patients and 9 patients, respectively), with no difference between patients undergoing secondary surgery and surveillance only.

CONCLUSION

Reporting of histological features and adherence to surveillance colonoscopy needs improvement. Long-term adverse outcome rates might be higher than previously reported, irrespective of whether secondary surgery was performed.
A public mid-density genotyping platform for cultivated blueberry (Vaccinium spp.)
Authors: Zhao Dongyan , Sapkota Manoj , Glaubitz Jeffrey , Bassil Nahla , Mengist Molla , Iorizzo Massimo , Heller-Uszynska Katarzyna , Mollinari Marcelo , Beil Craig Thomas , Sheehan Moira
Published: April 2024

Small public breeding programmes have many barriers to adopting technology, particularly creating and using genetic marker panels for genomic-based decisions in selection. Here we report the creation of a DArTag panel of 3,000 loci distributed across the tetraploid genome of blueberry (Vaccinium corymbosum) for use in molecular breeding and genomic prediction. The creation of this marker panel brings cost-effective and rapid genotyping capabilities to public and private breeding programmes. The open access provided by this platform will allow genetic data sets generated on the marker panel to be compared and joined across projects, institutions and countries. This genotyping resource has the power to make routine genotyping a reality for any breeder of blueberry.
The Singapore National Breast Screening Programme: Principles and Implementation
Authors: Wang S C
Published: April 2024

The Singapore Breast Screening Project (1993-1996) showed that mammographic screening in Singaporean women shifts the size and stage of screen-detected breast cancers downwards and markedly increases the rate of detection of ductal carcinoma in situ, with acceptable recall, needle biopsy and interval cancer rates. Breast cancer is the leading cause of death in Singaporean women. Singapore has one of the highest age-adjusted breast cancer incidences in Asia. Although this is much lower than in the West, for women aged 45-49 years, the breast cancer incidence in Singapore is the same as for women in Australia, Canada or the United States. The latest Singapore Cancer Registry data shows that the age of peak incidence of breast cancer in Singaporean women has risen from 45-49 years in the period 1993-1997 to 50-55 years in the period 1998-1999. This suggests that the age-specific incidence of breast cancer in Singaporean women is shifting more to a pattern usually seen in Western nations. These factors, together with reconfirmed evidence of mortality benefit from breast cancer screening trials, led the Singapore government to establish the first population-based mammographic breast screening programme in Asia, the Singapore National Breast Screening Programme (BreastScreen Singapore). It uses a distributed model of mammography service, with centralised reading and assessment, co-ordinated by the Singapore Health Promotion Board. It is unique in that women co-pay at each step of the screening and assessment process. The programme, launched in January 2002, has adopted international standards of breast screening practice and breast cancer detection. To date, the initial targets for the first year have been met. Several key policies and issues over the programme’s implementation are presented.
MR Imaging of the Fetal Brain and Spine: A Maturing Technology
Authors: Griffiths P D , Paley M N J , Whitby E H
Published: April 2024

Introduction: We describe the background and refinements to a 3-year research study designed to evaluate the role of magnetic resonance (MR) imaging in detecting and defining abnormalities of the fetal central nervous system in utero.

Methods: We describe our experience of using ultra-fast MR imaging methods (specifically single-shot fast spin echo) in 250 fetuses at various gestational ages. All fetuses had known or suspected brain or spine abnormalities based on antenatal ultrasound imaging. We describe the ethical issues raised by this type of work and the differences in diagnostic accuracy between ultrasound and MR imaging.

Results: We show that MR imaging can be performed in a clinical environment with a high degree of success: only 2 women out of 250 could not be examined (1 was claustrophobic and the other was too large for our scanner). In the 100 cases of singleton pregnancies, where detailed follow-up is available, there is a >40% improvement in diagnostic accuracy when MR imaging is included in the fetal assessment compared to ultrasound alone.

Conclusion: We conclude that in utero MR imaging is a powerful tool in the assessment of fetal brain and spine abnormalities, and suggest that further work be undertaken to provide a widely available clinical service.
Radionuclide Therapy of Hepatocellular Carcinoma
Authors: Keng G H W , Sundram F X
Published: April 2024

Introduction: Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Surgical resection is generally accepted as the first choice treatment of HCC. Many non-surgical techniques have been developed and used for the treatment of inoperable HCC, with limited efficacy. This paper studies the role of radionuclide therapy in the treatment of inoperable HCC and in an adjuvant setting following curative resection of HCC.

Materials and Methods: Relevant articles published between 1980 and 2002 were reviewed. Articles were identified through a Medline search using the key words hepatocellular carcinoma, iodine-131 (I-131), lipiodol, yttrium-90 (Y-90), rhenium-188 (Re-188), monoclonal antibodies and anti-ferritin.

Results: The objective response rate of patients with HCC treated with intra-arterial I-131 lipiodol was 40% to 70% and the median survival was between 6 and 9 months. The efficacy of I-131 lipiodol was similar to transarterial chemo-embolisation, but appears to be better tolerated by patients. A median survival of 9.4 months to 54 weeks was achieved using intraarterial Y-90 microspheres for the treatment of HCC. Tumours in 4 patients became resectable after treatment. Re-188 lipiodol is a relatively new radiopharmaceutical used for the treatment of HCC. The results of a pilot study have shown Re-188 lipiodol to be a safe and cost-effective radiopharmaceutical for the treatment of HCC via the intra-arterial route. Its efficacy should be subjected to further evaluation. The use of radio-labelled monoclonal antibodies, such as anticarcinoembryonic antigen and antiferritin, for the treatment of HCC has yielded encouraging results but these forms of treatment are largely experimental and limited to a few centres. Intra-arterial treatment using I-131 lipiodol in an adjuvant setting for patients following curative resection of HCC has resulted in improved disease-free and overall survival. The 3-year survival for the treatment and control groups were 86.4% and 46.3%, respectively.

Conclusion: Radionuclide therapy presents another interesting option for the treatment of HCC amidst the wide array of non-surgical modalities available.
Imaging of Paediatric Mediastinal Masses
Authors: Frush D P
Published: April 2024

A review of mediastinal masses in children is important for several reasons. First, the mediastinum is the common location for thoracic masses in children. Second, the type and frequency of masses differ in children compared with adults. Third, anatomic variations can be misinterpreted as mediastinal masses. Lastly, there are special technical considerations for imaging mediastinal masses in children. This article is derived from a literature review and the author’s personal experience with imaging mediastinal masses. Figures are used to illustrate the spectrum of lesions in the anterior, middle and posterior mediastinum in children. Familiarity with the types of masses, frequency of presentation and imaging features are extremely valuable in determining the appropriate subsequent care for the child.
The Impact of ILO Convention No. 182 (1999) on Safeguarding Against Child Labor in Indonesia
Authors:   Faculty of Law, Universitas Diponegoro, Jl. Prof. dr. A. Suroyo, Kampus Tembalang, Semarang, Indonesia, Naufal Bahy Wijdan , Prabandari Adya Paramita ,   Faculty of Law, Universitas Diponegoro, Jl. Prof. dr. A. Suroyo, Kampus Tembalang, Semarang, Indonesia, Wibawa Kadek Cahya Susila ,   Faculty of Law, Universitas Diponegoro, Jl. Prof. dr. A. Suroyo, Kampus Tembalang, Semarang, Indonesia
Published: April 2024

Child labor poses a serious challenge to Indonesia's commitment to children's rights and workplace protection. ILO Convention No. 182 has become a crucial global guideline in combating this issue. Using doctrinal legal research with an analytical descriptive component and includes the comparative approach, the statute approach, and the historical approach. Using secondary data, which included primary, secondary, and tertiary legal material and with library research and examined resources relating to the topics under investigation with qualitative analysis. Before ratification, weak enforcement and inadequate regulations left child workers vulnerable to health risks and exploitation. The ratification marked a pivotal moment, aligning Indonesia's laws with international standards to better safeguard children from exploitative labor practices, emphasizing the urgent need for stronger protections and enforcement measures.
Modification Model for the Hand Ball as the Learning Material for Physical Education for Improving Discipline and Cooperative of the Students
Authors:   Yogyakarta State University, Jl. Colombo Yogyakarta No.1, Karang Malang, DI Yogyakarta, 55283, Indonesia, Setyawan Bayu , Hermawan Hedi Ardiyanto ,   Yogyakarta State University, Jl. Colombo Yogyakarta No.1, Karang Malang, DI Yogyakarta, 55283, Indonesia
Published: April 2024

This development research aims to develop a modified model of handball games to improve discipline and cooperation of students. With this development research, it is hoped that it can become one of the references for sports physical education and health teachers in providing handball game material in learning at school. This development research uses the ADDIE development model, consisting of the Analysis (analysis), Design (planning), Develop (Development) Implement (Implementation), Evaluate (evaluation) stages. The subject of this research is a high school in Sleman district. The quality assessment of the Baboi Game Handbook developed was carried out by 1 handball game expert, 1 PJOK learning material expert, 1 media expert, and 1 field practitioner PJOK teacher who is a civil servant and certified educator. Field trials were carried out on a small scale and large scale. Small-scale trials were conducted at SMAN 1 Cangkringan, then large-scale trials were conducted at 3 schools, namely SMAN 1 Sleman, SMAN 2 Sleman and SMAN 2 Ngaglik. The data collection instrument used a questionnaire. Data analysis to determine the effectiveness of the game was carried out by t test, on the results of pretest and posttest. The result of the research is the baboi game guidebook. The baboi guidebook was tested on material experts, handball game experts, media experts and field practitioners. The results of the game expert validation get a percentage of 93%, which means very feasible. Furthermore, validation from media experts gets a percentage of 64% which means feasible and validation of sports physical education and health teacher field practitioners gets a percentage of 83% which means very feasible. Thus the baboi guidebook product that has been prepared is declared feasible for use in physical education learning at school. The results of the effectiveness test carried out obtained a percentage of 33.94% effect on students. The advice given is the addition of strategies to win the game and accompanied by pictures of techniques performed to make it more interesting and facilitate the understanding of readers.
Factors Affecting Mathematics Performance: Basis for an Intervention Plan
Authors:   Southern de Oro Philippines College, Cagayan de Oro City, Philippines, Apus Jalou S. , Quirap Erlinda A. ,   Southern de Oro Philippines College, Cagayan de Oro City, Philippines
Published: April 2024

Mathematics, being a highly advanced field of Science, is closely linked to success in modern society as it is considered a necessary skill. This study sought to determine the extent to which attitudes, parental influence, and self-efficacy are factors that affect learners' performance in Mathematics; to detect learners' Mathematics performance throughout the First Quarter of the School Year 2023 - 2024; to determine the significance of the relationships between factors affecting performance in Mathematics and learners’ First Quarter Mathematics performance of the School Year 2023 -2024; and to find out which of the independent variable/s singly or in combination best predict/s performance in Mathematics; and also to create an intervention plan based on the study's findings. There were one hundred seventy-six (176) Grade 6 learners from the District of Laguindingan schools, Division of Misamis Oriental that participated in the survey. The instrument used was adapted and modified from Peteros et al. (2019), Silao (2018), and Dagdag et al. (2020). The data gathered were analyzed using frequency, percentage, mean, standard deviation, Pearson Moment Correlation, and multiple regression analysis. The findings of the study showed that attitude toward Mathematics is the best indicator of Mathematics performance. The researcher recommends that the DepEd officials, administrators, parents, and stakeholders work together to deal with learners' Mathematics performance. Teachers may conduct parent workshops or training sessions and counseling on how to set realistic, achievable goals based on the child's capabilities.
Religious Analysis of Women's Sociological and Cultural Concerns
Authors:   Northern technical university , Kirkuk technical institute ,department of survey techniques & Kirkuk , 36000, Ehsan Saman Ali , Nooraldeen Dr. Farooq Abbas ,   Northern technical university , Kirkuk technical institute ,department of electrical techniques & Kirkuk , 36000
Published: April 2024

Islamic law has prioritized addressing women's issues, particularly societal issues, which are crucial as women are the core of society and comprise half of it. Women are not only wives but also mothers, sisters, and daughters, playing a significant role in society. It is essential that they are not left uninformed about their affairs, given the equal importance of their male counterparts. Islamic law emerged to provide clear guidance on its significance and its impact on humanity, society, culture, and the economy. The first portion examines the inherent and acquired traits of women, as well as their capacity to navigate social and economic circumstances. This includes their resilience in marriage and business, as well as the inherent and acquired advantages that males possess over them. The second issue pertains to the ethical principles and compassion that are relevant in many aspects of society. This discussion covers several aspects of rights, such as human rights, equality, civil rights and their classifications, as well as women's employment and education. The third subject of discussion is to the position of women in religious laws and ancient societies. The research technique included a series of definitive findings and deductions that we arrived at via a comprehensive examination and thorough understanding of the subject matter from all angles.
Assessment of the biological effect of natural silicon when entering the body of experimental animals with drinking water. Part 1
Authors: Egorova Natalija A. , Rakhmanin Yurii A. , Mikhailova Rufina I. , Khrypach Ljudmila V. , Alekseeva Anna V. , Ryzhova Irina N. , Kochetkova Marina G. , Knyazeva Tat’jana D.
Published: April 2024

Introduction. The biological effect of natural silicon (Si) and its hygienic regulation in drinking water still remain subjects of controversy in the scientific literature and in the practice of providing favourable conditions for water use by the population. In this regard, an assessment was made of the effect of natural silicon contained in drinking water in concentrations close to the maximum permissible concentration on the body of laboratory animals.
Materials and methods. Drinking waters containing natural Si at MPC levels in water were studied, their effect was assessed in a three-month experiment on 80 white outbred male rats. Observations were made of the general condition, appearance of the animals, body weight dynamics, water consumption.
The morphological composition of whole blood was studied. Biochemical indices of the condition of internal organs, including the liver, were determined
in serum samples (the ALT and AST activity, the level of total protein and albumin), pancreas (α-amylase activity), kidneys (creatinine content), as well as lactate dehydrogenase activity as a nonspecific indicator of tissue damage.
Results. In animals received 17±3.4 mg/L silicon with drinking water at a hardness of 2.25±0.47 mg-eq/L, a significant decrease in ALT activity was found on the 30th and 90th days of the experiment, AST – on 90th day, increase in the content of total protein and albumin in the serum on the 30th day of the experiment. Drinking water with silicon concentrations of 20.5±4.1 mg/L and hardness 3.55±0.76 mg-eq/L decreased ALT activity and serum creatinine concentration on the 30th day and increased amylase activity on the 90th day of the experiment. The animals had the highest water consumption and intake of silicon from drinking water over the first month of the experiment.
Limitations. Limitations of the study are related to the short duration of observation and the small number of points for determining biochemical parameters over time.
Conclusion. Consumption of drinking water containing natural silicon for 90 days led to changes in biochemical indices, largely indicating the positive effect of the element in concentrations of 17±3.4 mg/L and 20.5±4.1 mg/L on the body of laboratory animals.
On the issue of assessing the blood lipid spectrum in working men of different ages
Authors: Rakhmanov Rofail S. , Bogomolova Elena S. , Razgulin Sergey A. , Narutdinov Denis A. , Antyuganov Stepan N. , Kalyuzhny Evgeny A.
Published: April 2024

Introduction. Harmful working conditions contribute to the development of dyslipidemia Goal – assessment of the blood lipid spectrum in men of different age groups under conditions of occupational stress. Materials and methods. We analyzed the lipid spectrum of the blood in men aged up to 40 years (groups No. 1, 2 with different work experience, n=22 and n=20) and over 40 years of age (group No. 3, n=20). Assessed working conditions. Nutritional status, diet, physical activity, tobacco smoking, and alcohol consumption were determined. Result. Working conditions are harmful in terms of tension of 3.2 degrees. Physical activity is insufficient, 47.3% have three meals a day, 52.7% have two meals a day. In groups under 40 years of age with different years of experience, 68.2% and 63.2% are overweight; in people over 40 years old, 55.0% are overweight, class I obesity. at 20.0%. The proportion of smokers is 4.5%, 10.0% and 20.0%. With increasing age and experience, triglycerides increased (from 1.12±0.95 to 1.53±0.94 (p=0.022), total cholesterol (from 5.04±1.22 to 6.31±1.2, p=0.001), low-density lipoproteins (from 3.8±0.98 to 4.83± 1.11, p=0.01) mmol/l; proportions of people with hypertriglyceridemia (from 9.1 to 43.8%), hypercholesterolemia (from 40.9% to 93.7%), high LDL-C (from 47.6 to 93.75%); in subgroup No. 1, 19.0%, No. 2, 33.4% had HDL-C below normal. Lipid atherogenicity increased from 3.34±0.13 to 3.95±0.27 (p=0.031). Limitations. Men under 40 and over 40 years of age with varying years of experience working in hazardous work conditions. Conclusion. Hard work with poor nutrition and physical inactivity contributes to atherogenic changes in blood lipids. It is proposed to expand the list of studies to assess the atherogenicity of lipids in trained workers; in people with strenuous work, determine at an earlier age for the prevention of cardiovascular diseases.
Occupational prevalence rates in metallurgists in the Sverdlovsk Region
Authors: Gazimova Venera G.
Published: April 2024

Introduction. The previous analysis conducted for 2003–2022 showed ferrous industry employing over twenty five thousand people to make the most contribution to occupational disease incidence rates in the Sverdlovsk Region since 68.6 % of its workers are affected by industrial exposures above occupational safety standards. The purpose of the study was the analysis of occupational disease incidence in workers of a ferrous metal processing plant of the Sverdlovsk Region and assessment of the impact of adverse factors of the work environment and industrial processes on its rates.
Materials and methods. Long-term occupational disease incidence in workers of the ferrous metal processing plant has been analyzed by the causative agent, nosology, age, gender, and job. Data of the reporting form No. 1-T (working conditions) for the study period have been scrutinized; comparative data evaluation by working conditions and occupational disease incidence rates has been made.
Results. High incidence rates of work-related diseases in the metallurgists indicate to a significant proportion (70 %) of them to be exposed to occupational hazards. The established 20-year rate at the enterprise was 5.6 and 1.6 times higher than the regional and Russian averages in this industry, respectively. Increased gas and dust levels in the workplace air remain the leading health risk factors in ferrous metallurgy.
Limitations. The limitation of this study was the lack of annual data on workers by job preventing calculation of job-specific disease incidence rates per 10 thousand workers.
Conclusion. Despite the substantial modernization of the metallurgical complex, metal processing technology still does not comply with safety standards, thus requiring the development and implementation of science-based preventive measures aimed at maintaining workers’ health.
Contemporary Paradigm of Anticoagulant and Antiplatelet Therapy: Revolutionary Approaches to Assessing Blood Coagulation in the Laboratory and Using Instrumental Methods
Authors:   Laboratory of Applied Nanotechnology of Belousov, Belousov Andrey
Published: April 2024

Statement of the Problem: Impairment of the blood coagulation system remains a relevant issue in clinical practice. A striking example of this is the fact that despite the administration of anticoagulant therapy, up to 35% of COVID-19 patients were hospitalized in the intensive care unit with thromboembolic complications. Prophylactic and therapeutic methods for the hemostatic system, recommended by various protocols, have a general nature. Moreover, they introduce dissonance into the clinical clarity of appropriate anticoagulant and antiplatelet use and fail to provide practitioners with the necessary fundamental knowledge to understand the aspects of clinical tactics for correcting the hemostatic system. Uncertainties remain regarding how to correctly choose a specific anticoagulant and determine its effective dose based on individual clinical and laboratory data, which laboratory markers of the coagulation system should be investigated, and whether they always reflect the true picture of hemostasis. Methodology and Theoretical Orientation: This article briefly presents the main aspects of the functioning of the blood coagulation system, points of application for pharmacological agents, and provides objective information for clinicians about the mechanisms of action of major anticoagulants and antiplatelets. Effective and practical methods for assessing the hemostatic system are recommended. Findings: The proper correction of the hemostatic system can only be carried out by a highly qualified specialist - a clinical transfusiologist, who possesses a comprehensive understanding of the functioning of the coagulation and anticoagulation systems, the platelet and fibrinolysis systems, knows the points of application and mechanisms of action of the pharmacological agents and blood components used, and takes into account internal and external factors that influence hemostasis. Conclusion and Significance: Empirical prescription of anticoagulant and antiplatelet therapies, based solely on instructions and clinical protocols without objective comprehensive analysis of the hemostatic components, is not only ineffective but also life-threatening for the patient. Hemostasiogram (coagulogram) and D-dimer measurements cannot serve as the sole determining markers for monitoring the coagulation system. Evaluation of the blood coagulation system should only be carried out based on a comprehensive analysis of hemostasiogram data, complete blood count, thromboelastography (TEG), and data from all relevant systems.
Intergenerational Programs and Projects as a Proposal for Psychosocial Action in the Promotion of Active Aging
Authors:   Department of Psychology, University of Cordoba, Spain, Tamara Gutiérrez-Domingo
Published: April 2024

Introduction: Active aging promoted by the World Health Organization (WHO) promote not only to add years to life, but also life to years. The pillars of active aging are based on health, safety, participation and education for life. To offer the possibility for older people to actively participate in society, there are different strategies, among which intergenerational programs and projects stand out. Objective: This mini-review aimed to review the value of intergenerational programs and projects in promoting active aging, through one of its fundamental pillars: the integration and participation of older adults. Method: The methodological procedure used in this paper involved a narrative approach with analysis from different sources. Different databases were consulted (WoS, PubMed, SciELO), and organizations such as the WHO and various oficial resources were used as sources of information. Results: Intergenerational programs and projects are plans coordinated and designed by educational centers, senior centers and other organizations and associations - public and private - that want to work together for the mutual benefit of older adults, children and youth. After review the benefits of intergenerational programs and projects, it stands out one of the recent and successful iniciative implemented in Spain -the intergenerational program “Adopt a Grandparent”. This iniciative is dedicated to fostering connections between different generations with the aim of alleviating situations of loneliness among older people. Discussion and Conclusions: Participation between generations brings us closer to a more intergenerational society. The social network formed through bidirectional synergies can positively impact aging, serving as a compass for the health and psychological well-being of older people. In essence, advocating for the promotion of intergenerationl programs and projects, as leading of the sphere social policies enables the construction of a society for all ages with psychosocial benefits.
Healthcare Dynamics at the Hajj: Analysing Qatar’s Medical Unit During Mass Gatherings
Authors:   Primary health care corporation (PHCC), Qatar, AlFehaidi AlAnoud Saleh , M Abdulla Fatima Ibrahim ,   Primary health care corporation (PHCC), Qatar, AlMesaifri Meshal Abdulla ,   Primary health care corporation (PHCC), Qatar, Ahmed Zeinab ,   Primary health care corporation (PHCC), Qatar, Abdulhadi Khalid ,   Primary health care corporation (PHCC), Qatar, Mustapha Teblesi ,   Primary health care corporation (PHCC), Qatar
Published: April 2024

Mass gathering events pose significant healthcare challenges, including the spread of infectious diseases, strain on local medical resources, and the high density of participants
Prevention and Care of Oral Manifestations in Cancer Patients Receiving Chemotherapy and Head and Neck Radiation Therapy. Systematic Review
Authors:   Department of Oral and Maxillofacial Surgery, Yerevan State Medical University after M. Heratsi, Armenia, Mathevosyan Davit , Hakobyan Gagik ,   Department of Oral and Maxillofacial Surgery, Yerevan State Medical University after M. Heratsi, Armenia
Published: April 2024

Purpose: The purpose of this systematic review was to evaluate current evidence to prevent and care of oral manifestations chemotherapy and head and neck radiation therapy. Methods: Study selected if they met the following criteria: design - random allocation of participants; participants - anyone with cancer receiving chemotherapy or radiotherapy treatment for cancer; interventions - agents prescribed to prevent oral complication. Search keywords terms included head and neck cancer, dental care, prevention of complications of cancer, oral tissue lesions manifestationin, chemotherapy, head and neck radiation therapy, length of hospitalisation, cost and patient quality of life. Results: Conducted a preliminary search and reviewed 132 titles and abstracts in this review and 48 full-text articles were selected of high methodological quality. This systematic review analyzes the main complications of oral tissues resulting from chemotherapy and radiation therapy in the head and neck area and provides practical recommendations for the management and prevention of complications in this category of patients. The main methods of treating patients with malignant tumors in the maxillofacial area are surgical method, radiation therapy and chemotherapy. The treatment depends on the clinical and morphological characteristics of the tumor and requires the use of all methods simultaneously or in a certain sequence. Radiation and chemotherapy treatments not only have systemic side effects, but also side effects in the treatment area. Against the background of antitumor treatment, there is an exacerbation of concomitant chronic diseases, including odontogenic ones. Pathological changes appear on the mucous membrane oral cavity, on the skin, in the subcutaneous tissue, in the salivary glands and in the bone marrow of the jaw bones. Poor oral hygiene and chronic odontogenic lesions can cause the development of episodic fevers and other general complications. All this requires stopping or changes in the tactics of antitumor treatment, which reduces its radicalism. Conclusion: The current systematic review demonstrated that regular extensive oral health education, sanitation of the oral cavity, carried out before treatment by an oncologist, will avoid or reduce the frequency complications in the maxillofacial area, improve the quality of life of an oncology patient. Dental care for such a patient has features and requires an individual approach.
Contributing and Hindering Factors of Learner’s Persistence in a Free Basic Education
Authors: Hyoduk Kim , Ortega-Dela Cruz Ruth A.
Published: April 2024

Access to free basic education is a critical cornerstone for the development of individuals and societies. However, despite efforts to provide free education, learner persistence remains a challenge in many regions. Hence, the study was conducted to discuss contributing and hindering factors affecting learner’s persistence. A survey was conducted among 79 pupils from Kinder to Grade IV. Key informants consisting of the teachers, parents, and three former students also formed part of the respondents. The findings showed that contributing factors were mostly teacher and school related. While hindering factors were student and  classroom related. By understanding these factors, policymakers and educators can design targeted interventions to enhance the effectiveness of education initiatives. Thus, stakeholders must collaborate to create an environment where learners are empowered to overcome barriers and pursue their educational aspirations.
University-level entrepreneurship education: a bibliometric review using Tree of Science
Authors: Cervantes Muñoz Maria Angelica , Devece Carlos , Peris Ortiz Marta
Published: April 2024

Entrepreneurship education helps students build the skills, abilities, attitudes, and aptitudes they need to start a business. Universities play a key role in educating and transforming people. However, the academic literature in this area is fragmented. This article identifies the main areas in this field throughout its history based on a review of the literature. A scientometric study was conducted based on the results of a document search in Scopus. Using Tree of Science software, the most important documents were classified based on a network of citations. The results reveal three main perspectives: the impact of entrepreneurship education, entrepreneurship education methodologies, and new trends in entrepreneurship education. Researchers can use these results to propose ways to strengthen entrepreneurship education