bluuebunny/crossref_metadata_2025 huggingface dataset:
Dietary supplement using cockroach meal: impact on growth indices and biochemical responses in hybrid catfish
Authors: Kolawole Abiola Olabisi , Adamu Kabir Mohammed , Usman Ibrahim Baba , Mohammed Yakubu Manbe , Aliyu-Paiko Mohammed
Published: May 2023

Globally the need to substitute fishmeal with other animal protein sources in the fish diet has gained more attention; which is occasioned by the increasing cost of fish. A 12-week trial was conducted to ascertain the growth indices and biochemical response of hybrid catfish (Clarias gariepinus(♀) and Heterobranchus bidorsalis (♂)) fed cockroach meal supplement. A total of 800 hybrid catfish were randomly distributed into four dietary treatments (Diet A- control feed), Diet B (50 % cockroach and 50 % fishmeal), Diet C (100 % cockroach meal) and Diet D (100 % fishmeal). Each treatment was replicated with 35 fish per experimental pond in a completely randomized design. Progressive weight gain was determined bi-weekly. At the end of the study period, fishes were randomly sacrificed for proximate compositions and plasma biochemical analyses (glucose, triglyceride, cholesterol, total protein, albumin) using standard protocols. The study revealed that growth parameters (Weight gain, Average weight gain, Protein efficiency ratio, Feed Conversion rate, Specific growth rate and Survival rate (SR) were influenced by the dietary treatments (p>0.05). The highest weight gain was recorded in Diet 1 (8847.73±292.65 g) > Diet 2 (7816.33±121.71 g)>Diet 3 (7811.67±566.08 g) >Diet 4 (7022.00±44.193 g). Similarly, the best feed conversion ratio was found in fish fed Diet A (10.12±0.01),>Diet B, C and D had the same values of 0.11 g respectively. There was no significant (p>0.05) difference in plasma biochemical indicators measured when compared to the control (Diet A). Thus, indicating that all the fish were healthy and had normal physiological activities. Cockroach meal can therefore, be used as a feed supplement without having any adverse effect on the growth and well-being of hybrid catfish fingerlings
EFFET DES FUMURES ORGANIQUES ET DES PRATIQUES AGRICOLES SUR LES PROPRIETES PHYSICO-CHIMIQUES DES SOLS EN CULTURE PURE ET ASSOCIEE DE TOMATE DANS LARRONDISSEMENT V DE NIAMEY (NIGER)
Authors:   Laboratoire Biologie/ENS/ Universite Abdou Moumouni Niamey, Niger., Salissou Ibrahim Jamilou , Doka Dahiratou Ibrahim ,   Laboratoire Biologie/ENS/ Universite Abdou Moumouni Niamey, Niger., Moussa Baradje ,   Faculte DAgronomie, Universite Abdou Moumouni, Niamey, Niger., Maidoukia Abdoul Razack Harouna ,   Laboratoire Biologie/ENS/ Universite Abdou Moumouni Niamey, Niger., Kiari Saidou Addam ,   Departement de Gestion des Ressources Naturelles, INRAN Niamey, Niger., Sabiou Mahamane ,   Departement de Gestion des Ressources Naturelles, INRAN Niamey, Niger., Youssouf Mohamadou ,   Faculte DAgronomie, Universite de Say, Niamey, Niger., Maria Teresa Barral ,   Departamentode Edafoloxia e QuimicaAgricola, Universidade de Santiago de Compostela, Espagne., Nunez Remigio Paradelo ,   Departamentode Edafoloxia e QuimicaAgricola, Universidade de Santiago de Compostela, Espagne.
Published: May 2023

La pauvretes des sols en nutriments au Niger figure parmi les contraintes majeures a la culture maraichere.Dans ce contexte, la gestion efficace des ressources en eau et la fertilisation des sols saverent necessaires pour maintenir, rebondir les rendements des cultures et ameliorer la fertilite des sols.Lobjectifvise a ameliorerla production de la tomate, element nutritionnel de base dans lalimentation nigerienne et a une bonne gestion durable de la fertilite des sols et didentifier le modele ideal damelioration des conditions de culture de cette plante.Un dispositif experimental de Ficher a ete mis en place dans la zone de Saguia a Niamey et les traitements a base des fumures organiques (bouse des vaches, bouse de chevres et fiente des volailles), a des differentes doses ont ete appliques sur les proprietes des sols de culture de tomate.La granulometrie,le pH, la composition du complexe dechange cationique, la presence delements en trace metalliques, la stabilite des agregats, la glycoproteine de la glomaline ont ete analyses sur le sol de la couche 0-20 cm par les methodes danalyses physico-chimiques. Les resultats ont montre que les sols etudies presentent une texture sablo-limono-argileuse et un pH optimal de 8,2 favorable a la culture de tomate, du taux eleve en matiere organique. Les bases echangeables analysees ont montre quil y a une quantite importante en calcium (Ca2+) et magnesium (Mg2+). Ensuite, les teneurs en potassium (K+) et sodium (Na+) du sol presentent des valeurs acceptables pour lensemble des echantillons de solLutilisation des fumures organiques et des pratiques agricoles permettait de reduire lacidite et dameliorer lactivite biologique du sol.En occurrence lassociation et la fertilisation organique a une dose adequate sont des solutions envisageables pour ameliorer la productivite de la tomate au Niger et en particulier dans la zone de Saguia.
PEMPHIGUS VEGETANS OF NEUMANN: A CASE REPORT OF A RARE VARIANT OF PEMPHIGUS VULGARIS
Authors:   Department of Dermatology & Venereology, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, Morocco., Soukaina Sektaoui , Zoubida Mehsas ,   Department of Dermatology & Venereology, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, Morocco., Marwa Asermouh ,   Department of Dermatology & Venereology, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, Morocco., Meriem Meziane ,   Department of Dermatology & Venereology, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, Morocco., Nadia Ismaili ,   Department of Dermatology & Venereology, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, Morocco., Laila Benzekri ,   Department of Dermatology & Venereology, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, Morocco., Karima Senouci ,   Department of Dermatology & Venereology, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, Morocco.
Published: May 2023

Pemphigus vegetans is a rare variant of pemphigus vulgaris characterized by periorificial papillomatous vegetations. We present the case of a 77-year-old female patient with a history of type 2 diabetes and hypertension who presented with painful verrucous lesions on her tongue. The examination revealed a cerebriform tongue with small, hard, confluent verrucous swellings, which is a well-known sign seen in pemphigus vegetans. A biopsy revealed acantholysis and absence of keratinocyte necrosis, leading to the diagnosis of Neumann-type pemphigus vegetans. The patient was prescribed prednisone and trichloroacetic acid, which resulted in successful treatment. Management of pemphigus vegetans should be individualized based on the patients clinical presentation and response to treatment.
A COMPARATIVE STUDY BETWEEN EPIDURAL NALBUPHINE AND FENTANYL WITH BUPIVACAINE FOR POST OPERATIVE ANALGESIA IN LOWER LIMB SURGERIES
Authors:   Associate Professor, Department ofAnaesthesia and Critical Care, Al Ameen Medical College Hospital Athani Road, Vijayapur, Karnataka., B. Birajdar Sanjeev , Faheem Ahamed Peerzade Sayed ,   Assistant Professor, Department of Anaesthesia and Critical Care, Al Ameen Medical College Hospital, Athani Road, Vijayapur, Karnataka., Ali K. Shabeer ,   Resident, Department ofAnaesthesia and Critical Care, Al Ameen Medical College Hospital, Athani Road, Vijayapur, Karnataka., Shahver Sultana Syeda ,   Resident, Department ofAnaesthesia and Critical Care, Al Ameen Medical College Hospital, Athani Road, Vijayapur, Karnataka., Afzal A. Mohammed ,   Resident, Department ofAnaesthesia and Critical Care, Al Ameen Medical College Hospital, Athani Road, Vijayapur, Karnataka.
Published: May 2023

Background:The shorter duration of action of typical local anaesthetics used for spinal anaesthesia demands the early need for postoperative analgesia. Epidural analgesic administration reduces the stress reaction to pain and surgery, reduces the requirement for systemic analgesics, and promotes early rehab.1 It was discovered that using opioids as an adjuvant to local anaesthetics has synergistic effects. The advantages of this combination were improved pain alleviation, motor sparing, and less toxicity.2 Objective:To compare the efficacy of epidural analgesia by using fentanyl and nalbuphine as adjuvants along with bupivacaine following lower limb surgeries with respect to Onset, Duration, and side effects. Meterials and Methods:Prospective randomized doubled blind comparative study would be conducted on 60 adult patients of ASA grade I & II in the age group of 18 to 59 years of either sex, posted for lower limb surgeries after taking informed written consent. Patients were randomly divided on an alternative basis into 2 groups of 30 each. In study conducted in AL-AMEEN MEDICAL COLLEGE. VIJAYAPUR, KARNATAKA during the period of April 2021 to December 2022. If visual analogue score is more than one ,GROUP A: Patient received 50ug of fentanyl + 2.5 ml 0.5% bupivacaine diluted to 10ml with distilled water given epidurally (0.125%). GROUP B: Patient received 5mg of nalbuphine +2.5 ml 0.5% bupivacaine diluted to 10ml with distilled water given epidurally (0.125%). . Noting onset and duration analgesia also monitoring of patients SBP,DBP,SpO2,RR,VAS score till 15 min followed by 30 min,1hr ,2hr,4hr ,6hr,8hr is done and asked for any side effects like nausea ,vomiting, pruritis ,sedation and urinary retention. Conclusion: Epidural fentanyl has faster onset of action compared to nalbuphine and has longer duration of action compared to nalbuphine , for post operative epidural analgesia. There was no any statistically significant side effects in any of the two groups.
Construir y transformar el conocimiento desde la afectividad y el modelo dialogante
Authors: Rivera Alzate Jhon Delio
Published: May 2023

El Diccionario de la Real Academia define la afectividad como “conjunto de sentimientos, emociones y pasiones de una persona”, y el conocimiento desde una perspectiva filosófica puede ser entendido como un proceso por el cual la realidad se refleja y reproduce en la mente humana. La afectividad se convierte en un elemento importante que permite incentivar a los alumnos en la búsqueda de nuevos saberes, así como su construcción y transformación práctica en diferentes escenarios, a través de propuestas dialogantes que integren lo cognitivo, lo socio-afectivo y lo práxico. El siguiente escrito tiene como objetivo analizar desde una postura crítica y reflexiva la importancia que tiene la afectividad en la adquisición del conocimiento, y una propuesta dialogante que permita abordar otros temas fundamentales en el proceso educativo de los aprendices.
Zero-Biased and Visible Light-Driven Immunosensing of Cardiac Troponin I Biomarker Based on a BiOI/S-g-C3N4/Bi-NaTaO3 Photoelectrochemical Platform
Authors: Caldas Greicy Kelly , de Menezes Alan , dos Santos Clenilton , Pereira Silma Regina , Luz Rita de Cássia , Damos Flávio
Published: May 2023

This work describes the development of a platform based on bismuth oxyiodide (BiOI), sulfur-doped graphitic carbon nitride (S-g-C3N4), and bismuth-doped sodium tantalate perovskite (Bi-NaTaO3) for zero-biased photoelectrochemical immunosensing of cardiac troponin I (cTnI) biomarker. The spectroscopic, structural, morphological, and compositional characteristics of the photoelectrochemical (PEC) materials were evaluated by Raman and Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS). Electrochemical impedance (EI) measurements were performed under the incidence and absence of light to investigate the effects of photons on the charge transfer resistance of the photoelectrochemical platform. The influence of the cTnI biomarker on the photoelectrochemical response of the anti-cTnI antibody-modified photoelectrochemical platform (anti-cTnI/BiOI/S-g-C3N4/Bi-NaTaO3/FTO) was evaluated by measuring the photocurrent of the system. The immunosensor presented a linear response range from 1 pg mL-1 to 50 ng mL-1, mean recovery percentage between 95.98 and 99.78% in real human serum samples, and selectivity for the cTnI biomarker.
¿Es posible una bioética intercultural decolonial?
Authors: Martínez Dueñas William Andrés
Published: May 2023

Este dossier coordinado por el editor invitado Álvaro Acevedo-Merlano, permite plantear la discusión sobre el pluralismo en el ámbito de la bioética y su posible aplicación global. Estos análisis e investigaciones se adhieren a los de otros números especiales, que han tenido el espíritu de mostrar las tensiones entre las visiones pluralistas y universalistas en aspectos tan relevantes como la salud (Vol. 20 Núm. 2 del 2021) o el constitucionalismo (Vol. 21 Núm. 1 del 2022), entendiendo que estos procesos emergen de dinámicas interculturales e inter-locales. En tal sentido, estos dossiers invitan a pensar, no solo la necesidad del pluralismo, sino que además plantean los retos de lograrlo en lo referente a los sistemas de salud, jurídicos o en este caso bioéticos.
Nutraceuticals a Food for Thought in the Treatment of Parkinson’s
Disease
Authors: Bansal Keshav , Singh Sakshi , Singh Vanshita , Bajpai Meenakshi
Published: May 2023

Background:

Brain disorders are presently one of the most serious and challenging
health issues in the world. A significant portion of morbidities and fatalities worldwide are caused
by these brain disorders. Parkinson's disease (PD) is a neurological condition that develops when
dopaminergic neurons are lost in the substantia nigra, causing cognitive and motor impairment.

Objectives:

Conventional treatment modalities, including dopamine replacement therapy and
optimization of dopaminergic transmission approaches, don’t address the pathogenic processes
primary to the symptoms of PD and usually become the least essential with time. Researchers are
aiming to provide effective treatment in treating PD with minimizing adverse consequences. In
the past few years, a number of studies on nutraceuticals have been conducted to produce foods
with fewer adverse effects and increased therapeutic effectiveness. The use of these nutraceuticals
is typically risk-free and can be coupled with the patient's current common pharmacological therapy
to enhance the standard of living and lessen PD symptoms.

Conclusion:

The current review focuses on a number of important nutritional compounds and dietary
changes that have been shown to be effective against a number of the pathogenic pathways
involved in the onset and progression of Parkinson's disease (PD), and further lights the justification
for their prospect use in the treatment and prevention of PD.
Rethinking Tako-tsubo Cardiomyopathy: The Contribution of Myocardial
Pathology and Molecular Imaging
Authors: Sestini Stelvio , Coppola Angela , Dona Manjola , Martini Anna Lisa , Tardelli Elisa , Montelatici Giulia , Laghai Iashar , Arena Angela , Carli Giulia , Pestelli Francesco , Maraviglia Bianca , Bruni Giulia , Mazzeo Christian , Fedeli Luca , Mansi Luigi
Published: May 2023

Background:

Despite substantial research, the mechanisms behind stress Tako-tsubo
cardiomyopathy (TTC) remain rather elusive.

Objective:

The purpose of this paper was to provide a detailed review of the mainstream factors
underlying the pathophysiology of TTC, highlighting the novel contributions of molecular pathology
and in-vivo molecular imaging.

Methods:

A careful literature review selected all papers discussing TTC, specifically those providing
novel insights from myocardial pathology and cardiac molecular imaging.

Results:

Results concerning myocardial pathology, defect extension, sites and relationships
between functional parameters underline the existence of a causal relationship between a determinant
(e.g., the release of catecholamines induced by stress) and an outcome for TTC, which is not
limited to a reversible contractile cardiomyopathy, but it includes reversible changes in myocardial
perfusion and a long-lasting residual deficit in sympathetic function. Besides, they reinforce the
hypothesis that sympathetic nerves may exert a complex control on cardiac contractile function,
which is likely to be direct or indirect through metabolism and microvascular perfusion changes
during anaerobic and aerobic conditions.

Conclusion:

TTC is characterized by acute transient left ventricular systolic dysfunction, which
can be challenging to distinguish from myocardial infarction at presentation. Catecholamineinduced
myocardial injury is the most established theory, but other factors, including myocardial
metabolism and perfusion, should be considered of utmost importance. Each effort to clarify the
numerous pathways and emerging abnormalities may provide novel approaches to treat the acute
episode, avoid recurrences, and prevent major adverse cardiovascular events.
Design, Synthesis and Antimicrobial Activity of 1,3-Diazine Derivatives
Authors: Jadhav Pranali A. , Jagtap Jayashree R. , Deodhar Meenakshi N. , Chavan Rajashri S. , Pawar Smita J.
Published: May 2023

Background:

Pyrimidines have been shown to possess numerous biological activities, such as antimicrobial, anticancer, anticonvulsant, antiviral, and anti-inflammatory.

Objective:

Encouraged by these data, the synthesis of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4- amino-6-phenylpyrimidine-5-carbonitrile (3a-g) was performed.

Methods:

4-amino-2-mercapto-6-phenylpyrimidine-5-carbonitrile was dissolved in an aqueous sodium hydroxide solution, and to this clear solution, 2-chloromethyl-1H-benzimidazole in methanol was added, and the reaction mixture was stirred under reflux to get the desired product. The structures of the newly synthesized compounds were confirmed by their physical, chemical, and spectral data. The synthesized derivatives were screened for their in vitro antibacterial activity against Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, and Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa, by using ciprofloxacin as a reference standard. While, their antifungal activity was evaluated against Aspergillus niger and Candida albicans using fluconazole as a reference drug. The docking study was performed to check the interactions of target compounds (3a-g) with homo sapiens DHFR (PDB: 1S3V), bacterial (S. aureus) DHFR (PDB: 2W9T), and DHPS (PDB: 1AD4) protein. The dock score and binding interactions were recorded.

Results:

The antimicrobial activity study indicated compounds with chloro (3b), fluoro (3f), and bromo (3g) substituents to show good antibacterial as well as antifungal activity. The docking study revealed that the same compounds, i.e., 3b, 3f, and 3g, showed good dock score and comparable interactions compared to the reference ligand (trimethoprim/sulfadiazine), which confirmed their selectivity.

Conclusion:

It can be presumed that the synthesized compounds have the capability for further promotion as novel antimicrobial agents.
Investigation of Developmental Toxicity Profile of Edible Lablab (Lablab
purpureus (l.) Sweet Purpurea) bean Extract using Brine Shrimp and Zebrafish
Authors: Ghosh Rakesh , Pramanick Arghya , Sarkar Nilanjan , Mukherjee Swarupananda , Kumari Amrita , Roy Kalyan , Karunakaran Gauthaman , Mal Mainak , Chakraborty Mainak
Published: May 2023

Background:

Developmental toxicology deals with the effects of compounds on fertility and with birth defects that could occur at any stage of the reproductive cycle. In this study, we evaluated the teratogenic effects of Lablab purpureus (L.) Sweet beans on zebrafish embryo.

Objectives:

The developmental toxicity study was carried out to evaluate the toxicity induced by Lablab purpureus (L.) Sweet on zebrafish embryo. We also studied the cytotoxicity of Lablab purpureus (L.) Sweet beans.

Methods:

Zebrafish embryos were exposed to a methanolic extract of Lablab purpureus (L.) Sweet beans at concentrations of 10,25,50, and 100 μg/ml starting from 24 hours post fertilization (HPF) to 72 HPF. Developmental defects, if any, were observed under a microscope. Cytotoxicity of Lablab purpureus (L.) Sweet beans were also evaluated by using brine shrimp and the corresponding LC50 value of the methanolic extract of Lablab purpureus (L.) Sweet beans were also calculated.

Results:

The LC50 value of the methanolic extract of Lablab purpureus (L.) Sweet beans were found to be 77 μg/ml. However, some forms of developmental toxicity were observed in zebrafish embryos when treated with different concentrations of Lablab purpureus (L.) Sweet beans extract.

Conclusion:

The methanolic extract of Lablab purpureus (L.) Sweet beans were found to be cytotoxic in brine shrimp, and the LC50 value was found to be 77 μg/ml. However, there was some level of developmental toxicity in the Zebrafish embryo model at different concentrations of Lablab purpureus (L.) Sweet beans extract.
Curcumin-conjugated Nanoparticles: An Approach to Target Mitochondria
Authors: Suvarna Vasanti , Sawant Niserga , Desai Namita
Published: May 2023

Background:

Unconjugated nanoparticles used in the treatment of cancer and various metabolic
and neurodegenerative disorders exhibit extended blood circulation time, inhibition of enzymatic degradation,
and increased chemical stability of the encapsulated therapeutic molecules. However, the unconjugated
nanoparticles often show off-target effects and lack of specificity, which limit their applications in
the healthcare system.

Objective:

Curcumin, a polyphenolic compound known for its proficiency to scavenge reactive oxygen
species attributed to antioxidant activity and anticancer effects associated with mitochondrial dysfunction,
is one of the most effective therapeutic agents. Therefore, with respect to chemotherapeutic strategies, the
development of mitochondrial targeting curcumin nanoparticles for target-specific drug delivery has been
extensively studied.

Conclusion:

The present review has focused on diverse curcumin-loaded nanoparticles targeting mitochondria
along with their improved delivery potential, enhanced localization and biodistribution profile.
Structural Insights to the Pathophysiology of Effector Induced Immunostimulation
in Salmonella Typhimurium: Biocomputational Methods
Authors: Choudhury Abhigyan
Published: May 2023

Introduction:

The worldwide impact of the foodborne pathogen Salmonella can never
be overstated, nor can be the fatal threat of septicemia in patients infected with its Typhimurium
serovar. Behind the hyperimmune response in the case of septicemia lies a critical phenomenon of
the bacterial pathogenic signals being sensed by different pattern recognition receptors, such as the
Typhimurium effector proteins that are detected by toll-like receptors.

Methods:

To mitigate such a threat, precise structural and functional description of these effectors
is necessary. The same has been addressed in this article using accelerated biocomputational techniques,
beginning with the identification of the functional niche of the effectors and their influence
over other proteins.

Results:

The molecular crystal structures were retrieved, and rigorous molecular docking experiments were conducted among the TLRs and effector proteins in order to examine the interactions. The interactions were thereby evaluated and screened according to their respective strengths using parameters including binding affinity, dissociation constant, hydropathy variation, etc. SopB effectors were found to be detected by three different TLR proteins and GtgE by two other TLRs, while SifA, SrfJ, and SsaV had only a single interacting TLR partner each. Interestingly, TLR9 presented lower sensitivity towards PAMPs of this bacterium.

Conclusion:

Normal modal analyses in combination with atomistic molecular dynamics simulations that tend to imitate natural cytosolic environments reveal stable and consistent interactions and realistic conformations among the effector-bound TLR complexes. The findings open up new avenues for the development of targeted therapies against Salmonella, which could significantly reduce the global burden of this foodborne pathogen.
Socio-economic factors leading to divorce in Gunungkidul Regency
Authors: Harsoyo Yohanes , Darmawan Indra
Published: May 2023

This research aims at: (i) analyzing the main issue leading to divorce in family; (ii) analyzing the socio-economic factor causing the divorce; and (iii) identifying what the families need to prevent divorce. This research employs the method of qualitative-descriptive survey with 5 respondents, consisting of 20 men and 32 men who are divorced. Data collection was conducted using questionnaires. The quantitative findings were investigated with a qualitative approach by interview, exclusively with the respondents who had given their consent to provide information in a face-to-face setting. Based on the field data, it is found that the main factors leading to divorce are economy (37.04 percent) and extramarital affairs (29.63 percent). Meanwhile, the main socio-economic factors that cause divorce include low family income (29.55 percent), household debt (18.18 percent), distrust in household financial management (11.36 percent), unemployed husband/wife (9.09 percent), and greater concern on the family of origin (9.09 percent). As a measure to avoid divorce, most of the respondents (34.67 percent) feel the need for pre-marital seminar, 22.67 percent of them need marriage counseling services, 22 percent consider marriage age maturation is necessary, and 16.67 percent need household financial management training.
Blended Care in Patients With Knee and Hip Osteoarthritis in Physical Therapy: Delphi Study on Needs and Preconditions
Authors: Weber Franziska , Kloek Corelien , Arntz Angela , Grüneberg Christian , Veenhof Cindy
Published: May 2023

Background

Osteoarthritis is a major public health concern. Despite existing evidence-based treatment options, the health care situation remains unsatisfactory. Digital care options, especially when combined with in-person sessions, seem to be promising.

Objective

The aim of this study was to investigate the needs, preconditions, barriers, and facilitators of blended physical therapy for osteoarthritis.

Methods

This Delphi study consisted of interviews, an online questionnaire, and focus groups. Participants were physical therapists, patients with hip and/or knee osteoarthritis with or without experience in digital care, and stakeholders of the health care system. In the first phase, interviews were conducted with patients and physical therapists. The interview guide was based on the Consolidated Framework For Implementation Research. The interviews focused on experiences with digital and blended care. Furthermore, needs, facilitators, and barriers were discussed. In the second phase, an online questionnaire and focus groups served the process to confirm the needs and collect preconditions. The online questionnaire contained statements drawn by the results of the interviews. Patients and physical therapists were invited to complete the questionnaire and participate in one of the three focus groups including (1) patients; (2) physical therapists; and (3) a patient, a physical therapist, and stakeholders from the health care system. The focus groups were used to determine concordance with the results of the interviews and the online questionnaire.

Results

Nine physical therapists, seven patients, and six stakeholders confirmed that an increase of acceptance of the digital care part by physical therapists and patients is crucial. One of the most frequently mentioned facilitators was conducting regular in-person sessions. Physical therapists and patients concluded that blended physical therapy must be tailored to the patients’ needs. Participants of the last focus group stated that the reimbursement of blended physical therapy needs to be clarified.

Conclusions

Most importantly, it is necessary to strengthen the acceptance of patients and physical therapists toward digital care. Overall, for development and usage purposes, it is crucial to take the needs and preconditions into account.

Trial Registration

German Clinical Trials Register DRKS00023386; https://drks.de/search/en/trial/DRKS00023386
Data Analysis of Physician Competence Research Trend: Social Network Analysis and Topic Modeling Approach
Authors: Yune So Jung , Kim Youngjon , Lee Jea Woog
Published: May 2023

Background

Studies on competency in medical education often explore the acquisition, performance, and evaluation of particular skills, knowledge, or behaviors that constitute physician competency. As physician competency reflects social demands according to changes in the medical environment, analyzing the research trends of physician competency by period is necessary to derive major research topics for future studies. Therefore, a more macroscopic method is required to analyze the core competencies of physicians in this era.

Objective

This study aimed to analyze research trends related to physicians’ competency in reflecting social needs according to changes in the medical environment.

Methods

We used topic modeling to identify potential research topics by analyzing data from studies related to physician competency published between 2011 and 2020. We preprocessed 1354 articles and extracted 272 keywords.

Results

The terms that appeared most frequently in the research related to physician competency since 2010 were knowledge, hospital, family, job, guidelines, management, and communication. The terms that appeared in most studies were education, model, knowledge, and hospital. Topic modeling revealed that the main topics about physician competency included Evidence-based clinical practice, Community-based healthcare, Patient care, Career and self-management, Continuous professional development, and Communication and cooperation. We divided the studies into 4 periods (2011-2013, 2014-2016, 2017-2019, and 2020-2021) and performed a linear regression analysis. The results showed a change in topics by period. The hot topics that have shown increased interest among scholars over time include Community-based healthcare, Career and self-management, and Continuous professional development.

Conclusions

On the basis of the analysis of research trends, it is predicted that physician professionalism and community-based medicine will continue to be studied in future studies on physician competency.
Older Adults and New Technology: Mapping Review of the Factors Associated With Older Adults’ Intention to Adopt Digital Technologies (Preprint)
Authors: Schroeder Tanja , Dodds Laura , Georgiou Andrew , Gewald Heiko , Siette Joyce
Published: May 2023

BACKGROUND

Ongoing advancements in digital solutions support older adults’ healthy aging and well-being. However, a unified synthesis of sociodemographic, cognitive, attitudinal, emotional, and environmental factors that influence older adults’ intention to use these new digital technologies is still lacking. Understanding the salient factors that influence older adults’ intention to use digital technologies will help to ensure that technology is developed appropriately and contextually. This understanding is also likely to contribute to developing technology acceptance models specifically for the aging generation, by reorganizing principles and constructing objectivity criteria for future research studies.

OBJECTIVE

This review aims to identify the key factors associated with older adults’ intention to use digital technologies and to provide a comprehensive conceptual framework to describe the relationships between these key factors and older adults’ intention to use digital technologies.

METHODS

A mapping review was conducted using 9 databases from inception to November 2022. Articles were selected for review if they had an evaluative component of older adults’ intention to use digital technologies. Three researchers independently reviewed the articles and extracted the data. Data synthesis was performed via narrative review and quality appraisal was measured using 3 different tools based on each article’s study design.

RESULTS

We identified a total of 59 articles investigating older adults’ intention to use digital technologies. The majority (40/59, 68%) of articles did not use an existing framework or model for technology acceptance. Studies mostly adopted a quantitative research design (27/59, 46%). We found 119 unique factors reported to influence older adults’ intention to use digital technologies. These were categorized into 6 distinct themes: Demographics and Health Status, Emotional Awareness and Needs, Knowledge and Perception, Motivation, Social Influencers, and Technology Functional Features.

CONCLUSIONS

Given the importance of global demographic change toward an aging society, there is surprisingly limited research on the factors that influence older adults’ intention to use digital technologies. Our identification of the key factors across different types of digital technology and models supports the future integration of a comprehensive perspective encompassing environmental, psychological, and social determinants for older adults’ intention to use digital technologies.
Participatory Approach for the Integrated and Sustainable Management of the PNVi
Authors: Jean-Pierre Bulambo Milenge
Published: May 2023

This study proposes an Analysis on the participatory management of Virunga National Park using SWOT analysis. We started from the constant incomprehension and perpetual opposition of the local population on the management of the PNVi. The question asked is to know the management strategy aimed at involving all the actors in the sustainable management of the Virunga National Park. After having presented and analyzed the data of our sample which were provided to us by 3 territories and a city including 12% in the territory of Nyiragongo, 15% in the city of Goma, 22% in the territory of Masisi and 51% in the territory of Rutshuru the size of the sample to be considered in relation to the strategies for involving the population in the sustainable management of the PNVi. The results showed that the best way to generate the PNVi would be the integrated management model, at least 42% of study participants proposed it, 31% proposed the multi-agent model, 20% proposed the traditional model policeman and 7% suggested private management.
El descubrimiento probatorio en Colombia: ¿verdad y justicia para las víctimas en el proceso penal?
Authors: Velandia Montes Rafael , Gómez Jaramillo Alejandro , Solarte Cuncanchón Ana María
Published: May 2023

El nuevo régimen procesal penal en Colombia establecido mediante la Ley 906 de 2004 ha significado una transformación profunda de la cultura jurídica colombiana, se pasó de un sistema de tendencia inquisitiva a uno de tendencia adversativa. Así, se introdujo el descubrimiento probatorio como elemento del debido proceso y mediante el cual, en principio, el acusador debe revelar toda la evidencia que pretenda usar en el juicio. Empero, el descubrimiento probatorio tiene particularidades en cuanto a quiénes están obligados a hacerlo y cómo se cumple tal obligación. En este trabajo se examina qué es el descubrimiento probatorio y sus características mediante el examen y análisis de la doctrina, ley y jurisprudencia, con énfasis en el derecho procesal penal colombiano. Asimismo, se indaga sobre el papel de las víctimas en el descubrimiento probatorio y su relación con el derecho a la verdad y justicia. Se concluye que el descubrimiento probatorio es un elemento del debido proceso y cuya carga corresponde al acusador y al acusado, mientras que la víctima debe actuar a través del acusador, so pena de generar un desequilibrio en el proceso penal.
El control preventivo de constitucionalidad como mecanismo de protección de la buena fe internacional
Authors: Pazo Pineda Oscar Andrés
Published: May 2023

El control de constitucionalidad ha atravesado distintas fases. En un inicio, se trató de una institución desacreditada, particularmente en Europa. Esto se debía a que el “culto a la ley” se encontraba arraigado en esa parte del mundo. En ese contexto, una forma inicial se hacer compatible esta noción con la del control de constitucionalidad fue el “control previo de constitucionalidad”, el cual permitía fiscalizar el contenido de las leyes, pero antes que estas fueran publicadas. Con posterioridad, esta herramienta ha sido incorporada con el propósito de evitar el surgimiento de la responsabilidad internacional del Estado. Este artículo busca demostrar cómo el control preventivo es indispensable para garantizar el equilibrio entre la supremacía constitucional y el principio pacta sunt servanda.
Sustitución Constitucional en Colombia: límites de reforma al Poder Constituyente Derivado (Función Legislativa)
Authors: Arboleda Ramírez Paulo Bernardo , Jiménez Ramírez Milton César
Published: May 2023

En el presente trabajo se estudia el fenómeno jurídico de la sustitución de la constitución, el cual se presenta cuando un elemento definitorio de la esencia de la Constitución de 1991, en lugar de ser modificado, es reemplazado por uno opuesto o integralmente diferente. En este orden de ideas, la sustitución de la constitución es una figura creada por la Corte Constitucional de Colombia mediante la sentencia C-551 de 2003. Así pues, el objetivo del trabajo se orienta a identificar el origen y desarrollo de la teoría de la sustitución de la constitución en la jurisprudencia constitucional.
Inteligencia artificial: un mecanismo para frenar la evasión fiscal sin vulnerar los derechos del contribuyente
Authors: Palomino Guerrero Margarita
Published: May 2023

A partir de una visión general de la ciencia de redes y aprendizaje de máquinas, se propone incorporar la inteligencia artificial para mejorar el control y el seguimiento del cumplimiento de obligaciones y construir la topología de los contribuyentes que incorporan prácticas indebidas para erosionar la base tributaria, partiendo de las experiencias positivas que el C3 de la UNAM dio a conocer en torno a la evasión y elusión fiscal en 2020. Además de propiciar que la autoridad pueda integrar los suficientes elementos de prueba para acreditar plenamente la legalidad de sus actos y, por ende, el respeto de los derechos del contribuyente que, con frecuencia se argumenta, son violentados.
Hacia el derecho humano al autoconocimiento en México a partir de las neuro-ciencias
Authors: Ramírez Bañuelos Jesús Francisco
Published: May 2023

Este artículo explora la necesidad de repensar las características del derecho respecto a los neuroderechos. Mediante un enfoque iusnaturalista, se reflexiona sobre la emergencia del derecho humano al autoconocimiento en México a partir de las neurociencias. La argumentación de este trabajo gira en torno al inconsciente del ser humano. Se analizan las limitaciones que tiene la construcción jurídica para proteger los procesos internos del cerebro y su consideración como un objeto relevante para determinar derechos y obligaciones. Se propone el neologismo de “intranomia” para distinguir los procesos internos cerebrales de la autonomía de la voluntad. Se concluye que el respeto, protección y garantía del inconsciente humano implica la deconstrucción de los esquemas tradicionales del derecho.
La Constitución de la República de Texas de 1836
Authors: Cárdenas Gracia Jaime
Published: May 2023

El ensayo reflexiona sobre la naturaleza, antecedentes y características de la Constitución de la República de Texas de 1836. Esta Constitución fue copiada de la de Estados Unidos e implicó el interregno jurídico previo a la incorporación de Texas a dicho país norteamericano. En el artículo se explican los elementos positivos y negativos de esa carta magna y se busca contextualizarlos cultural e históricamente.
El control de la constitucionalidad de la ley en México
Authors: Huerta Ochoa Carla
Published: May 2023

El control de constitucionalidad, reconocido en general como el medio jurídico más importante de salvaguarda del Estado de derecho, tiene como finalidad evaluar la conformidad de los actos de autoridad y de las normas inferiores con la Constitución. En este artículo, se aborda solamente en relación con lo previsto en el sistema jurídico mexicano sobre el control judicial de la constitucionalidad de la ley. Para lograr dicho objetivo, se ofrece una explicación del sistema de control de la constitucionalidad, actualmente operante en México, para reflexionar, desde la perspectiva de la teoría del derecho constitucional y el derecho vigente, sobre los medios y el parámetro de control de la constitucionalidad de la ley, así como los efectos jurídicos de la declaración de inconstitucionalidad.
Pogledi na pojavu purizma u hrvatskom kontekstu
Authors: Ivašković Igor
Published: May 2023

The article explores the problem of purism and the criteria for identification of purist interventions that usually occur after changes of political systems. From a theoretical point of view, the article analyzes the definition of purism and discusses the dilemma regarding the existence of a neutral period from the aspect of purism. In that context, it tries to explain why some Croatian linguists denote only some parts of Croatian history as purist. In the first part, the author identifies the problem of the definition of purism and the methodological problems of its observation, while in the second part the article offers a brief comparative overview of perspectives on the need for intervention in the Croatian language in the period 1918 - 1990. The author argues that purism should be assessed according to the degree and methods of removing undesired words from usage, and concludes that partial historical analyses will always result in finding that a particular regime pursued the policy of purism.Therefore, future studies of purism should include elements of comparison and criteria for the evaluation of the policy aggressiveness and of the ideology behind it. Without the latter, linguistic debates on purism, although not intended to qualify certain political regimes, remain primarily indicators of their authors’ political preferences.
Analysis of Problems of the Power System with a High Proportion of Solar Generation
Authors: Sitnikov S.A. , Shaytor N.M. , Gorpinchenko A.V. , Dubkov E.A.
Published: May 2023

The rapid development of solar energy has led to the creation of qualitatively new energy systems with a high share of solar generation. The behavior of systems of this kind in certain cases differs significantly from the behavior of traditional energy systems containing the predominant share of thermal power plants. Thus, a significant share of the generation of solar power plants as part of the power system, the lack of an adjustment range for reactive power and the generally accepted concept of modeling a solar power plant lead to the problem of introducing unnecessary restrictions to maintain the stability and reliability of the power system. At the same time, the problems of stability and reliability must be solved simultaneously with the problems of saving energy resources; this is precisely the problem of optimization. The balance between reliability and economy lies in meeting the required restrictions on the cross-sections of the power system. The analysis made it possible to determine the priority directions in the study of the operation of solar power plants as part of a unified energy system. The calculation of the daily schedule of power generation for a set of SESs located in the same meteorological conditions for two seasons of the year has been performed. The real regulation range of reactive power was determined and the analysis of participation in the rating of stability and reliability of power systems was carried out. These results were obtained during the study of the power system of the Republic of Crimea and the city of Sevastopol. One of the main conclusions of this paper is the lack of a general approach in the description of SES together with the control system in mathematical models for calculating steady-state and transient electric power modes. Given the growing trend towards digitalization, this issue is currently becoming more acute. The conclusions made will allow us to set a vector for the development of the study of the issues of connecting the SES to the unified energy system.
Method of the Generalized Approach to the Synthesis of Cam Mechanisms
Authors: Krokhmal N.N.
Published: May 2023

The technique of applying the equation of the geometric connection of links in the higher kinematic pair of a cam mechanism for the complete synthesis of a mechanism with a flat translationally moving pusher with an arbitrary angle of inclination of the plate is considered. A distinctive feature of the technique is that the equation of the cam profile envelope is derived from the equation of the geometric relationship of the cam and the pusher in the Cartesian coordinate system. All transformations, the solution of the original coupling equation and the envelope equation are carried out by the matrix method in the same coordinate system without switching to other coordinate systems and to graphical methods of their interpretation. As a result of the performed studies, calculated relations for determining the coordinates of the cam profile points at an arbitrary angle of inclination of the pusher plate were obtained. The formula for determining the curvature radius of the cam at an arbitrary inclination angle of the plate is derived. The procedure for determining the radius of the main cam circumference is proposed, taking into account the identified features of the cam profile plotting. Based on the developed methodology, software in the MathCad package has been created. The correctness of the methodology and software was tested on a numerical test case. In the course of computer modeling, the reason for the need to limit the value of the inclination angle of the plate is established, due to the phenomenon of cam profile self-intersection, which does not depend on the pressure angle and is not tracked by the condition of the convexity of its profile. The test results allow us to assert that the generalized method of flat cam mechanisms synthesis is correct and effective, therefore it has prospects of application, for example, for a cam mechanism with a flat rotating pusher.