bluuebunny/crossref_metadata_2025 huggingface dataset:
Influência da temperatura na resistividade elétrica do concreto e na cinética de corrosão da armadura
Authors:   Departamento de Materiais de Construção, Escola de Engenharia, Universidade Federal de Minas Gerais, Belo Horizonte-Mg, Brasil., Chiaradia L. C. , Almeida F. C. R. ,   Departamento de Materiais de Construção, Escola de Engenharia, Universidade Federal de Minas Gerais, Belo Horizonte-Mg, Brasil., Aguilar M. T. P. ,   Departamento de Materiais de Construção, Escola de Engenharia, Universidade Federal de Minas Gerais, Belo Horizonte-Mg, Brasil., Figueiredo E. J. P. ,   Escola de Engenharia Civil e Ambiental, Universidade Federal de Goiás, Goiânia-GO, Brasil.
Published: October 2023

O trabalho avaliou a influência da variação de temperatura nas medidas de resistividade elétrica e na cinética de corrosão em estruturas de concreto armado sujeitos a cloretos. Os concretos foram caracterizados fisicamente e mecanicamente aos 28 e 90 dias. Após 204 dias, as amostras foram submetidas a ciclos de ida e volta de temperatura partindo dos 55°C até -5°C. Os resultados indicaram que a cinética de corrosão e a resistividade elétrica variaram com a alteração da temperatura. Em temperaturas mais elevadas, os traços contaminados com Cl- demonstraram uma alta probabilidade de corrosão e uma diminuição dos valores de resistividade elétrica. Porém, na temperatura negativa a probabilidade de corrosão foi insignificante e os valores de resistividade elétrica os mais elevados.
Estudio patológico empleando ensayos de ultrasonido aplicado a estructuras en construcción
Authors:   Steel Concrete Test, La Paz, Bolivia., Ergueta G. A. , Quino M. V. ,   Steel Concrete Test, La Paz, Bolivia.
Published: October 2023

El estudio presenta los resultados de la evaluación de estructuras de hormigón armado utilizando Ensayos No Destructivos (END) basados en la Velocidad de Pulso Ultrasónico (VPU) con el objetivo de determinar la integridad y uniformidad del hormigón, así como detectar posibles anomalías causadas durante la construcción o por factores externos. Los resultados mostraron la distribución de daños en una estructura afectada por el fuego, la medición de la profundidad de fisuración en un elemento de hormigón y la uniformidad en diferentes componentes estructurales, que posteriormente permitieron elaborar el procedimiento de rehabilitación estructural correspondiente. El estudio demuestra la eficacia de los END y la VPU en la evaluación de estructuras de hormigón armado, permitiendo tomar decisiones inmediatas de reparación y rehabilitación.
¿Por qué de repente?
Authors:   COTCA, S.A., UPC, Barcelona, España., Alegre Heitzmann V. , Villalba Herrero S. ,   COTCA, S.A., UPC, Barcelona, España., Ródenas Alias V. ,   COTCA, S.A., Barcelona, España.
Published: October 2023

Se pretende concienciar sobre la importancia del estado límite de durabilidad a través del ejemplo de los muros de contención. Con este fin se presenta el caso del colapso repentino de un muro tras 40 años de vida útil, que se produjo en la junta fría de unión del cimiento corrido con la base del muro. El agua con cloruros había ido oxidando la armadura en esa sección, hasta que se produjo la cuña de rotura del talud y el muro colapsó sin avisar. La armadura no se había estrechado como una rotura típica de barras de acero corrugado a tracción. La sección estaba simplemente oxidada, y el muro de 8m cayó sobre la vía como un sólido rígido.
Patologias das construções: um estudo de caso das manifestações patológicas na estrutura do cais do porto do Mucuripe em Fortaleza-CE
Authors:   Conselho Regional de Engenharia e Agronomia – CREA-CE e Universidade Maurício de Nassau - UNINASSAU, JUAZEIRO DO NORTE, Ceará, Brasil., Machado R. W. L.
Published: October 2023

No presente trabalho foi realizado um levantamento e análise das patologias nas estruturas de concreto armado do cais do porto. O estudo fora realizado por meio de inspeções visuais da estrutura e assim foi possível analisar as patologias: corrosão, desagregação, problemas oriundos da presença do mar, fissuras, reações álcoli-agregado e as causas das manifestações das patologias existentes. Identificou-se a causas das manifestações, bem como os principais fatores que contribuem para a degradação das estruturas e proposição de medidas para solução dos problemas encontrados. No decorrer do trabalho será possível analisar as consequências da ausência de manutenção das estruturas de concreto que são expostas ao ambiente marinho, como no caso do cais. Para contemplar a realização do trabalho foi realizada uma pesquisa bibliográfica de estudos que pudessem contribuir com o artigo, e pode-se auferir ainda que é imprescindível que as construções de novas estruturas possam se adequar a conceituação de durabilidade, visando ainda à facilitação da realização da manutenção em face das patologias existentes ou que possam surgir.
Diagnóstico y proyecto de recalce estructural del Palacio Tampieri
Authors:   Facultad de Arquitectura, Universidad Nacional de Córdoba, Córdoba, Argentina., Zanni E. , Capdevila J. ,   Departamento de Construcciones Civiles, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
Published: October 2023

Se detalla el diagnóstico y recalce estructural del Palacio Tampieri, dentro de un proyecto de restauración integral. El edificio posee alto valor patrimonial, constituyendo uno de los dos palacios existentes en la Provincia de Córdoba, Argentina. Presenta fracturas en mamposterías portantes, provocadas por asentamientos diferenciales, al estar fundado sobre limos colapsables afectados por variaciones cíclicas del nivel freático. La metodología consistió en relevar las lesiones existentes, realizar cateos e indagación técnica e histórica de su construcción para diagnosticar su estado estructural y constructivo. La intervención se dividió en dos etapas: A) estabilizar y hermetizar el edificio, y B) rehabilitar y restaurar fachadas e interiores. Se concluye que los micropilotes hincados constituyen una alternativa válida para refundar edificios en suelos saturados, con intervenciones mínimamente destructivas.
Restauración de la fachada de la iglesia de San Pedro Apóstol de Agost. España
Authors:   Departamento de Ingeniería Civil. Universidad de Alicante. Alicante (España)., Ivorra S. , Spairani Y. ,   Departamento de Construcciones Arquitectónicas. Universidad de Alicante (España), Huesca J. A. ,   Departamento de Construcciones Arquitectónicas. Universidad de Alicante (España), Saura P. ,   Departamento de Construcciones Arquitectónicas. Universidad de Alicante (España), Jordá E. ,   nrique Jordá. Escultura y Proyectos Artísticos. Alicante (España)
Published: October 2023

Este trabajo describe los estudios realizados y la intervención llevada a cabo para la restauración de la portada de la fachada de San Pedro Apóstol en la Iglesia parroquial de Agost. Esta portada se realizó a finales del siglo XVIII en piedra calcárea. Tras una primera inspección y levantamiento gráfico de la misma se identificaron las lesiones, su origen y la solución a las mismas, empleando técnicas avanzadas de restauración. Los elementos de piedra dañados o destruidos por el paso del tiempo se han reconstruido bien mediante del uso de nuevos elementos o, en mayor parte, mediante el uso de morteros, arcilla expandida, fibra de vidrio y carbono junto con infiltraciones de resinas en las zonas disgregadas. Tras un proceso delicado proceso de intervención con técnicas innovadoras la fachada a finalizado su restauración en junio de 2023.
Avaliação da capacidade de autocicatrização de argamassas especiais contendo aditivo mineral cristalizante e agentes biológicos
Authors:   Departamento de Engenharia Civil, Universidade Federal da Integração Latino-Americana, Foz do Iguaçu, Brasil., Zottis A. L. , Possan E. ,   Departamento de Engenharia Civil, Universidade Federal da Integração Latino-Americana, Foz do Iguaçu, Brasil., Hasparyk N. P. ,   Departamento de Segurança de Barragens e Tecnologia, ELETROBRAS Furnas, Goiânia, Brasil.
Published: October 2023

A pesquisa avaliou o potencial de autocicatrização de argamassas com adição de bactérias e aditivo mineralizante. A mistura de referência (MREF) contou com cimento Portland CPV-ARI (400 kg/m³), adição de sílica ativa (10%) e cinza volante (25%), areia, superplastificante, fibra de polipropileno e água (a/c de 0,40). A partir deste, fez-se uma mistura com adição de Bacillus subtilis AP91 (MB) e outra com aditivo cristalizante (MMAD). Avaliou-se o potencial de autocicatrização e o desempenho das argamassas por ensaios físicos e mecânicos. MMAD obteve a maior resistência à compressão, 41,23 MPa, e a MB à tração, 6,97 MPa, aos 90 dias, além do maior incremento de velocidade ultrassônica, indicando que o uso de agentes biológicos é promissor na colmatação de fissuras.
Efecto de la realcalinización electroquímica en la adherencia del refuerzo de acero embebido en concreto
Authors:   Centro de Investigación en Corrosión, Campus 6, Universidad Autónoma de Campeche, México., Pérez López T. , Paat Estrella J. A. ,   Facultad de Mecánica y Eléctrica campus Xalapa-Veracruz. Universidad Autónoma de Campeche, México, Torrez Pérez T. C. ,   Facultad de Ciencias Químico Biológicas. Universidad Autónoma de Campeche, México., del Pilar Reyes M. Y. ,   Tecnológico de Estudios Superiores de Valle de Bravo, Estado de México, México., Nieves Mendoza D. ,   Facultad de Ingeniería, Universidad Veracruzana, Campus Xalapa-Veracruz, México.
Published: October 2023

Se presentan resultados de ensayos de adherencia concreto-acero posterior a los procesos de carbonatación acelerada y realcalinización electroquímica. Muestras de 15 cm de sección por 30 de longitud con acero de refuerzo fueron carbonatadas y realcalinizadas electroquímicamente a intensidades de corriente de 1, 2 y 4 A/m2, por 28 días de acuerdo a las normas NMX-C-553-ONNCCE-2018, UNE-EN-1504 y NACE SP0107 2007. El seguimiento del Potencial de corrosión (Emc) y pH demostraron que las varillas embebidas en concreto sometidas a un proceso de carbonatación acelerada presentaron disminución de pH y despasivación, mismas que recuperaron con pH cercanos a 12 al someterlas a realcalinización electroquímica. Los ensayos de adherencia mostraron diferencias que pueden ser atribuibles a los procesos electroquímicos de la intercara.
Evaluación de hormigones con residuos de caucho destinados a rehabilitación en zona sísmica
Authors:   Centro Regional de Desarrollos Tecnológicos para la Construcción, Sismología e Ingeniería Sísmica, Fac. Reg. Mendoza – Univ. Tecnológica Nacional, Mendoza, Argentina., Castro G. A. , Barrera D. A. ,   Centro Regional de Desarrollos Tecnológicos para la Construcción, Sismología e Ingeniería Sísmica, Fac. Reg. Mendoza – Univ. Tecnológica Nacional, Mendoza, Argentina., Martín P. E. ,   Centro Regional de Desarrollos Tecnológicos para la Construcción, Sismología e Ingeniería Sísmica, Fac. Reg. Mendoza – Univ. Tecnológica Nacional, Mendoza, Argentina., Maldonado G. N. ,   Centro Regional de Desarrollos Tecnológicos para la Construcción, Sismología e Ingeniería Sísmica, Fac. Reg. Mendoza – Univ. Tecnológica Nacional, Mendoza, Argentina.
Published: October 2023

El crecimiento del parque automotor en Argentina y en el mundo entero, hacen que los residuos de los neumáticos fuera de uso se incrementen año tras año. Ante ello, existe una creciente necesidad de encontrar una deposición sustentable a los mismos. En el presente estudio se evalúa la influencia de diferentes contenidos de residuo de caucho incorporados en hormigones. Para ello, se evaluaron distintas propiedades físicas y mecánicas de los hormigones adicionados a efectos de analizar su desempeño. Las adiciones de caucho en peso correspondieron entre el 1% y el 10% del peso de arena y cemento.
Proposição de plano de manutenção teórico para extensão de vida útil de uma estrutura de concreto de 42 anos – Estudo de caso
Authors:   Programa de Pós Graduação em Estruturas e Construção Civil, Universidade de Brasilia, Brasilia, Brasil, Silva Pires L. A. ,   ML Engenharia Diagnóstica, Brasília, Brasil, da Cruz S. M. ,   Programa de Pós Graduação em Estruturas e Construção Civil, Universidade de Brasilia, Brasilia, Brasil., Marques Carvalho M. T. ,   Programa de Pós Graduação em Estruturas e Construção Civil, Universidade de Brasilia, Brasilia, Brasil., Martins Nascimento M. L. ,   ML Engenharia Diagnóstica, Brasília, Brasil
Published: October 2023

Este trabalho propõe um plano de manutenção para uma estrutura com 42 anos, localizada em Brasília, baseado no estudo da literatura e aplicação do método de previsão de Tutti para avanço da carbonatação para subsidiar a definição das ações e periodicidades. O plano pretende estender a vida útil da estrutura para 100 anos, com uma otimização entre manutenções preventivas e preditivas, visando a minimização das corretivas. Com o estudo, estabeleceu-se 3 diferentes ações: renovação da pintura, inspeção visual e inspeção especializada, com periodicidade de 5, 10 e 20 anos, respectivamente. A primeira é ação preventiva, de baixo custo e fácil execução, as demais são preditivas. A aplicação do plano e seus resultados permitem refinamento e aumento da precisão do modelo.
COVID-19 in PAEDIATRIC ONCOLOGY PATIENTS: INCIDENCE AND SEVERITY OF CLINICAL FEATURES IN CANCER VS. NON-CANCER PATIENTS
Authors:   Quratulain Zafar, Jamal Bakht
Published: October 2023

Diabetic retinopathy is one of the most common complications of diabetes which can lead to visual impairment or even blindness. However, early detection and prompt treatment can reduce the risk of visual impairment significantly. Therefore, it is important to detect the socioeconomic predictors of late presentation of diabetic retinopathy which was the objective of this study
EVALUATION OF HYPOTENSION AND ALLERGIC REACTION WITH PARENTERAL DROTAVERINE IN A TERTIARY CARE HOSPITAL
Authors:   Eman Tahir, Andleeb Sidrah
Published: October 2023

Drotaverine is an excellent anti-spasmodic and a vital drug for relieving spastic visceral pain. However, the incidence of hypotension and allergic skin reactions is a concern with drotaverin’es use. Aim: This study was intended to evaluate the risk of adverse effects with drotaverine in hospital patients. Method: It was a retrospective cross-sectional study for the total cases on drotaverine inj. for the year 2017. Data collection form was used.
Distribución espacial de las hospitalizaciones por enfermedad isquémica del corazón en Chile: 2002-2020
Authors: Cárdenas-Pizarro Jorge , Gómez-Varas Jorge , Maturana-Miranda Francisco , Fuenzalida-Díaz Manuel
Published: October 2023

Objetivo. Analizar la distribución espacial y tendencia temporal de egresos hospitalarios asociados con enfermedad isquémica del corazón (IHD, por sus siglas en inglés) en Chile, para el periodo 2002-2020. Material y métodos. Estudio ecológico mixto. Se incluyeron casos de IHD >=18 años registrados en Chile entre 2002-2020. Representación cartográfica a nivel comunal según sexo y residencia. Se utilizó autocorrelación espacial aplicando I de Moran local univariado por sexo. Tendencia temporal se evaluó mediante el modelo segmentado de Poisson (JP). Resultados. 434 061 casos totales. Se presentan tasas de hospitalización mínimas de 53 por cada 100 000 habitantes para sexo masculino y 32 por cada 100 000 habitantes para sexo femenino. Las tasas máximas determinadas corresponden a 638 por cada 100 000 habs. para sexo masculino y 364 por cada 100 000 habs. para sexo femenino. Las Comunas registran valores de I de Moran para hombres que tienden a dispersarse a medida que avanza el periodo analizado (0.247 a 0.334) y en el caso de las mujeres tienden a agruparse (0.244 a 0.223). Esta tendencia refleja comportamiento de aumento en los rangos etarios de 18 a 24 años y de 25 a 34 años para sexo femenino. Conclusión. Existe una transición de tasas bajas a altas durante periodo estudiado. Es posible agrupar comunas con valores altos en la zona Centro y Sur de Chile, y valores bajos en la zona Norte del país. La existencia de hospital, en promedio, afecta las tasas de utilización para ambos sexos.
Encuesta Nacional de Salud y Nutrición 2023: metodología y avances de la Ensanut Continua 2020-2024
Authors: Romero-Martínez Martin , Shamah-Levy Teresa , Barrientos-Gutiérrez Tonatiuh , Cuevas-Nasu Lucía , Bautista-Arredondo Sergio , Colchero M Arantxa , Gaona-Pineda Elsa B , Martínez-Barnetche Jesús , Alpuche-Aranda Celia , Gómez-Acosta Luz M , Mendoza-Alvarado Laura R , Rivera-Dommarco Juan , Lazcano-Ponce Eduardo
Published: October 2023

Objetivo. Presentar la metodología de la Encuesta Nacional de Salud y Nutrición 2023 (Ensanut 2023) y describir los procedimientos de inferencia para conjuntar la información colectada por la Ensanut Continua 2020-2024. Material y métodos. La Ensanut 2023 es la cuarta encuesta de la serie Ensanut Continua. Se describe el alcance de la Ensanut 2023 junto con sus procedimientos de muestreo, estimación, medición y organización logística. Además, se discute el procedimiento básico de estimación para analizar la integración de las encuestas Ensanut Continua 2020-2024. Resultados. La Ensanut 2023 obtendrá a nivel nacional al menos 11 720 entrevistas completas de hogar y 13 378 cuestionarios completos de adulto. La unión de las Ensanut Continua 2020-2023 permitirá, en general, estimar a nivel estatal prevalencias p≥5% en adultos, con confiabilidad tolerable según las recomendaciones del Instituto Nacional de Estadística y Geografía. Conclusiones. El análisis de la unión de la Ensanut Continua 2020-2023 permitirá iniciar la generación de estimaciones nacionales y estatales sobre el estado de salud y nutrición de la población mexicana.
La resistencia antimicrobiana, una amenaza en tres dimensiones
Authors: Lugo-Zamudio Gustavo E , Cureño-Díaz Mónica A.
Published: October 2023

Entre los principales problemas de Salud Pública podemos identificar a la resistencia antimicrobiana (RAM), definida por la Organización Mundial de la Salud (OMS) como aquella que se produce cuando los microorganismos (bacterias, hongos, virus y parásitos) sufren cambios al verse expuestos a los antimicrobianos, resultando que los medicamentos se vuelvan ineficaces y las infecciones persistan.
IKK2 controls the inflammatory potential of tissue-resident regulatory T cells
Authors: Cook Matthew , Cardinez Chelisa , Hao Yuwei , Kwong Kristy , Davies Ainsley , Downes Morgan , Chand Rochna , Feng Zhi-Ping , Enders Anselm , Vinuesa Carola , Miraghazadeh Bahar
Published: October 2023

Loss-of-function mutations have provided crucial insights into the immunoregulatory actions of Foxp3 + regulatory T cells (Tregs). By contrast, we know very little about the consequences of defects that amplify aspects of Treg function or differentiation. We report that mice heterozygous for an Ikbkb gain-of-function (GoF) mutation develop psoriasis. Doubling the gene dose (IkbkbGoF/GoF) results in dactylitis, spondylitis, and characteristic nail changes, which are features of psoriatic arthritis. IkbkbGoF mice exhibit a selective expansion of Foxp3 + CD25 + Tregs of which a subset express IL-17. These modified Tregs were enriched in both inflamed tissues and spleen, and their transfer was sufficient to induce disease without conventional T cells. Single-cell transcriptional and phenotyping analyses of isolated Tregs revealed expansion of non-lymphoid tissue (tissue-resident) Tregs expressing Th17-related genes, Helios, tissue-resident markers including CD103 and CD69, and a prominent NF-kB transcriptome. Thus, IKK2 regulates tissue-resident Treg differentiation, and overactivity drives dose-dependent skin and systemic inflammation.
Integrating Structure Time Series Forecasting and Multicriteria Decision Analysis for Adaptive Operational Risk Assessment: An Empirical Study Using Real-Time Data
Authors: Peng Guicang , Selvik Jon Tømmerås , Abrahamsen Eirik Bjorheim , Bang Knut Erik , Markeset Tore
Published: October 2023

This study presents a framework for integrating Multi-Criteria Decision Analysis (MCDA) and Structure Time Series (STS) prediction for multifaceted operational risk assessment often with highly dynamic risk determinants. In particular, by utilizing the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) as an MCDA method, the framework is able to prioritize risk determinants according to their inherent uncertainties’ impacts on their respective operational objectives, and by employing Seasonal Autoregressive Integrated Moving Average (SARIMA) as an STS technique, the framework emphasizes real-time knowledge utilization for iteratively reducing uncertainty. By integrating SARIMA and TOPSIS, the framework aims to construct a multivariate operational risk assessment profile that is prioritized and continuously updated by the latest data and knowledge.
Based on the proposed framework, the study constructs a mathematical model, coded by Python, and employs the model to perform an empirical assessment of 161 countries’ operational risk, using the Armed Conflict Location & Event Data Project’s (ACLED) real-time data. A comprehensive analysis of the model’s functionality, quality, and sensitivity is provided based on the assessment result. Conclusions and limitations are also discussed, highlighting the model’s theoretical novelty and practical implications.
Dynamics of an Age-Structured Tumor Cell Population Model with Nutrition
Authors: Liu Chunhua , Liu Xianning , Wang Yan , Wei Yangjiang
Published: October 2023

A nonlinear age-structured tumor population model, in which the tumor population is divided into proliferating and quiescent cells, and the probability of mitosis in proliferating cells are determined by the concentration of nutrient and the proliferating cells, is provided and analyzed. The dynamic behaviors of the model are investigated by means of semigroup operator theory. Firstly, a threshold called $R_{0}$ is proposed, and the model always exists a tumor-free steady state, which is locally asymptotically stable if $R_{0}<1$, and a sufficient condition for its global stability is also obtained. Secondly, a special piecewise function with time delay describing the 'birth' of proliferating cells is introduced, and a particular threshold $R_{0s}$ in accordance with it is obtained. If $R_{0s}>1$ it is shown that there exists a unique positive steady state, which is locally asymptotically stable once it appears. Further, several numerical analyses are carried out to illustrate the validity of the theoretical results, which shows that the nonlinearity of split rate not only halts tumor's exponential growth but also forces the tumor population converge to constant and sometimes even like the Gompertz growth. The results suggest that it may be a good treatment to prolong the split time as long as possible during tumor therapy.
Mathematics Subject Classification (2020) 34D20 · 35A25 · 92C37
Human capital indicators as influenced by SES, cognitive and non-cognitive skills: Evidence from Taiwan’s most recent PISA survey
Authors: Boman Björn
Published: October 2023

Taiwan’s high performance in the PISA surveys has not been unnoticed by researchers. However, both individual level research and cross-national research relevant for Taiwan’s PISA achievement is typically lacking, especially as regards the latest survey. This article examined Taiwan’s PISA mathematics and reading achievement in 2018 in two complementary studies, using individual level data (N = 7243) and cross-national data with aggregated data for 32 countries. At the individual level, socioeconomic and non-cognitive variables explain the most variance of PISA mathematics and reading. At the cross-national level, Taiwan’s greatest comparative advantage is the high cognitive abilities among schoolchildren. Individual level PISA data would likely benefit from cognitive ability tests and Five-Factor model variables as there is substantial unexplained variance.
Psoas mass index at the level of the third lumbar vertebra on computed tomography is a prognostic predictor for metastatic castration-sensitive prostate cancer
Authors: Owa Shunsuke , Sasaki Takeshi , Ikadai Ryota , Tabata Yusaku , Takeuchi Yushiro , Nishikawa Taketomo , Kato Momoko , Higashi Shinichiro , Sugino Yusuke , Masui Satoru , Nishikawa Kouhei , Inoue Takahiro
Published: October 2023

Background
Computed tomography-defined low skeletal muscle mass is associated with oncological outcomes in prostate cancer. However, its association with the outcomes in hormone-treated metastatic castration-sensitive prostate cancer is unclear. This study aimed to determine the association between metastatic castration-sensitive prostate cancer and psoas muscle parameters.
Methods
We retrospectively reviewed 121 patients with N1 and/or M1 metastatic castration-sensitive prostate cancer who underwent primary androgen deprivation therapy either with a luteinizing hormone-releasing hormone agonist/antagonist or with surgical castration accompanied by first-generation anti-androgen bicalutamide treatment between 2005 and 2021. Before treatment, the psoas muscle index at the level of the third lumbar vertebra (psoas muscle area [cm2]/height2 [m2]) and the mean Hounsfield units of the psoas muscle were evaluated in relation to oncological outcomes using non-contrast computed tomography.
Results
The median follow-up was of 56.9 months. Furthermore, 82 (67.7%) and 53 (43.8%) patients progressed to castration-resistant prostate cancer and died during follow-up, respectively. Multivariate analysis of castration-resistant prostate cancer-free survival and overall survival showed significant differences in the Gleason score, clinical N stage, and psoas muscle index (median cut-off: 3.044 cm2/m2). Kaplan–Meier curves of a novel prognostic model using these three risk factors showed significant differences (P <0.001).
Conclusions
A pretreatment low psoas muscle index was an independent predictor of a poor castration-resistant prostate cancer-free survival and overall survival in patients with N1 and/or M1 metastatic castration-sensitive prostate cancer. Our novel prognostic model could help predict worse outcomes in susceptible patients.
Carthamus tinctorius L. genome sequence provides insights into synthesis of unsaturated fatty acids
Authors: Dong Yuanyuan , Wang Xiaojie , Liu Xiuming , Yao Na , Jing Yang , Du Linna , Li Xiaowei , Wang Nan , Liu Weican , Wang Fawei , Li Xiaokun , Li Haiyan , Wang Yuanxin
Published: October 2023

Domesticated safflower (Carthamus tinctorius L.) is a widely cultivated edible oil crop. Here, we present the genome assembly for C. tinctorius variety Jihong01, which was obtained by integrating Oxford Nanopore Technologies (ONT) and BGI-SEQ500 sequencing results. The assembled genome was 1.04 Gb, and consisted of 32,379 protein-coding genes, 97.71% of which were functionally annotated. Safflower had a recent whole genome duplication (WGD) event in evolution history and diverged from sunflower approximately 37.3 million years ago. Comparative genomic and differential gene expression analyses at five stages of seed development revealed that genes encoding fatty acid desaturase 2, fatty acid desaturase 6 play key roles in determining linoleic acid composition. Analyses of fatty acids contents obtained from seeds at different stages revealed FAD2 and FAD6 are crucial for the biosynthesis of LA, the major fatty acids component of seed lipids. Our data can be used in breeding programs to improve quality traits and provide a foundation for further research on the natural properties of safflower.
Synthesis of meta-functionalized phenols and anilines
Authors: Wang Yong-Qiang , Zhao Bao-Yin , Jia Qiong
Published: October 2023

Phenols and anilines are of extreme importance for medicinal chemistry and material science. The development of efficient approaches to prepare both compounds has thus long been a vital research topic. The utility of phenols and anilines directly reflects the identity and pattern of substituents on the benzenoid ring. Electrophilic substitutions remain among the most powerful synthetic methods to substituted phenols and anilines, yet in principle achieving ortho- and para-substituted products. Therefore, the selective preparation of meta-substituted phenols and anilines is the most significant challenge. We herein report an efficient copper-catalyzed dehydrogenation strategy to exclusively synthesize meta-functionalized phenols and anilines from carbonyl substituted cyclohexanes. Mechanistic studies indicated that this transformation underwent a copper-catalyzed dehydrogenation/allylic hydroxylation or amination/oxidative dehydrogenation/aromatization cascade process.
Whether deep learning is an efficient method for carbon emission prediction research?
Authors: Yao Xiao , Zhang Hong , Wang Xiyue , Jiang Yadong , Zhang Yuxi , Na Xiaohong
Published: October 2023

Accurately predicting future carbon emissions is of great significance for the government to scientifically promote carbon emission reduction policies. Among the current technologies for forecasting carbon emissions, the most prominent ones are econometric models and deep learning, but few works have systematically compared and analyzed the forecasting performance of the methods. Therefore, the paper make a comparison for deep learning model, machine learning model, and the econometric model to demonstrate whether deep learning is an efficient method for carbon emission prediction research. In model mechanism, neural network for deep learning refers to an information processing model established by simulating biological neural system, and the model can be further extended through bionic characteristics. So the paper further optimizes the model from the perspective of bionics, and proposes an innovative deep learning model based on the memory behavior mechanism of group creatures. Comparison results show that the prediction accuracy of the heuristic neural network is higher than that of the econometric model. Through in-depth analysis, the Heuristic neural network is more suitable for predicting future carbon emissions, while the econometric model is more suitable for clarifying the impact of influencing factors on carbon emissions.
Exploring Chaos and Ergodic behavior of an Inductorless Circuit driven by Stochastic Parameters
Authors: Seth Soumyajit , Bera Abhijit , Pakrashi Vikram
Published: October 2023

There exist extensive studies on periodic and random perturbations of various continuous maps investigating their dynamics. This paper presents a random piecewise smooth map derived from a simple inductor-less switching circuit. The bifurcation parameter is bounded and randomly selected from a stationary distribution. Due to the stochasticity inherent in either the parameter values or the state variable, the time evolution of the state variable cannot be predicted at a specific time instant. We observe that the state variable exhibits completely ergodic behavior when the minimum value of the parameter is 2.0. However, the ensemble average of the state variable converges to a fixed value. For parameter values ranging from 2.0 to 3.5, the system demonstrates nonchaotic behavior and the absolute value of the Lyapunov exponent increases monotonically with the asymmetry (ap) of the distribution from which the bifurcation parameter values are sampled. We determine the probability density function of the random map and verify its invariance under any initial condition. The most noteworthy result is the disappearance of chaotic behavior when the lower range of the distribution is varied while maintaining a fixed upper threshold for a particular distribution, even though the nonrandom map exhibits an array of periodic and chaotic behaviors within that range.
A novel surface topography prediction method for hybrid robot milling considering the dynamic displacement of end-effector
Authors: Qin Xuda , Li Yifei , Feng Gongbo , Bao Zhengwei , Li Shipeng , Liu Haitao , Li Hao
Published: October 2023

There are extremely high requirements for the surface quality and integrity of parts in the automotive, aerospace and die/mold industry. Meanwhile, due to the advantages of large workspace, strong flexibility and low cost, the hybrid robots have shown broad application prospects in the above fields of machining or manufacturing. However, limited by the stiffness of robot joints and links, the surface topography of milled workpiece is more susceptible to the dynamic response caused by the variation of robot postures and cutting forces. The simulation of the surface topography in the robotic milling process remains a challenging goal. This paper focuses primarily on the dynamic displacement of end-effector for the TriMule hybrid robot as well as its impact on the topography of milled surface. In this paper, a framework model for predicting the topography of milled surface is developed first, and then further perfected by incorporating the dynamic displacement of the robot-tool system in the machining process. In this method, the dynamic model of the robot milling process is developed based on the stiffness of the TriMule hybrid robot within the entire workspace. After that, the finite element method is introduced to discretize the tool and workpiece, and the topography of the milled surface can be regenerated through the Boolean operations and the Z-MAP method. Finally, a series of validation experiments are conducted and the results indicate that the proposed model can be used to predict the topography of the surface milled by the hybrid robot in different postures.
Ursolic acid restores redox homeostasis and proinflammatory cytokines production in denervation-induced skeletal muscle atrophy
Authors: Yadav Aarti , Dabur Rajesh
Published: October 2023

Skeletal muscle (SkM) atrophy results from metabolic disorders causing body and muscle mass loss, affecting morbidity and mortality. Increased oxidative stress, inflammation, and poor prognosis are the leading causes of involuntary weight loss. Ursolic acid (UA), known for its antioxidant and anti-inflammatory properties, can potentially reduce oxidative stress and inflammation in muscles, but its effects on muscle mass regulation are still unknown. Therefore, present study investigated the medicinal efficacy of UA and its mode of action against murine model of SkM atrophy over 7 days of UA supplementation. Denervation-induced SkM atrophy significantly impacts both overall body weight and the weight of individual muscles (p < 0.05). However, supplementation with UA can effectively counteract these effects by promoting the synthesis of the slow-myosin heavy chain, thereby restoring body weight and myotube diameter. Moreover, UA also plays a crucial role in reducing the production levels of reactive oxygen species (ROS), lipid peroxidation (LPO), and caspase-3-like activity in atrophied muscles. UA also, prevents the leakage of creatine kinase (CK) through the upregulation of superoxide dismutase (SOD) and glutathione peroxidase (GPx) expression. Furthermore, the results obtained from qRT-PCR demonstrated a significant decrease in the levels of proinflammatory markers, namely IL-1β, IL-6, TNF-α, and TWEAK, approximately four-fold after the third day of the UA intervention. UA also upregulated PGC-1α, Bcl2, and Akt expression for maintenance of redox homeostasis.
Psychometric Properties and Validity of the Pros and Cons of Anorexia Scale: An Exploration of Anorexia Patients’ Endorsement of Benefits and Burdens of Their Illness, and Severity, Subtype and Motivation
Authors: Gregertsen Eva Cecilie , Mandy William , Armstrong Stephanie , Kanakam Natalie , Frampton Ian , Hennessey Georgia , Sodeke-Gregson Ayo , Cardinal Annie , Robinson Paul , Serpell Lucy
Published: October 2023

Background The egosyntonic nature of anorexia nervosa (AN) – or valued nature of the illness – has been highlighted as a possible maintaining factor in AN. As such, understanding egosyntonicity is a key issue in both assessment and treatment of AN, and solid instruments capturing the perceived benefits and burdens of AN may be useful to clinicians. Accordingly, the current study analysed the psychometric properties of the Pros and Cons of Anorexia Scale (P-CAN), including its relationship with motivation and illness severity.Methods 100 female AN patients completed the P-CAN, Eating Disorder Examination (ED) Questionnaire, Anorexia Stages of Change Questionnaire, Readiness and Motivation Questionnaire, and Concerns about Change.Results The P-CAN had good psychometric properties. Significant correlations with scales measuring ED psychopathology indicated meaningful concurrent validity. Endorsement of pros, alongside endorsement of the “hatred” con, was linked with greater ED pathology, greater readiness to change, lesser confidence, and lesser concerns about change. Endorsement of cons was linked with lesser ED pathology, lesser readiness to change, and greater concerns about change. The relationship between endorsement of pros and greater ED pathology was mediated by motivation.Conclusions The P-CAN is a clinically useful instrument for measuring perceived pros and cons in individuals with AN.
YAP/TAZ interacts with RBM39 to confer resistance against indisulam
Authors: Ando Toshinori , Okamoto Kento , Shintani Tomoaki , Yanamoto Souichi , Miyauchi Mutsumi , Kajiya Mikihito
Published: October 2023

The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ), are essential for cell growth and organ development. Emerging evidence revealed that the Hippo pathway and YAP/TAZ are frequently dysregulated by multiple genetic alterations in solid cancers including head and neck squamous cell carcinoma (HNSCC); however, the YAP/TAZ-nuclear interactome remains unclear. RNA-binding motif protein 39 (RBM39) enhances transcriptional activity of several transcription factors and also regulates mRNA splicing. Indisulam degrading RBM39 induce alternative splicing, leading to cell death. However, clinical trials of indisulam have failed to show the effectiveness. Therefore, clarifying the resistance mechanism against splicing inhibitors is urgently required. In this study, we identified RBM39 as a novel YAP/TAZ-interacting molecule by proteome analysis. RBM39 promoted YAP/TAZ transcriptional activity. We further elucidated that indisulam reduce RBM39/YAP/TAZ-mediated integrin or collagen expression, thereby inactivating focal adhesion kinase (FAK) important for cell survival. Moreover, indisulam also induced alternative splicing of cell cycle- or DNA metabolism-related genes. YAP/TAZ hyperactivation suppressed indisulam-induced RBM39 degradation, which restored the integrin/collagen expression to activate FAK, and alternative splicing, thereby conferring resistance against indisulam in vitro and in vivo. Our findings may aid to develop a novel cancer therapy focusing on YAP/TAZ/RBM39 interaction.
Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain
Authors: Domenico Lisa , Tanner Jared , Mickle Angela , Terry Ellen , Garvan Cynthia , Lai Song , Deshpande Hrishikesh , Staud Roland , Redden David , Price Catherine , Goodin Burel , Fillingim Roger , Sibille Kimberley
Published: October 2023

Chronic musculoskeletal pain is a leading cause of disability worldwide. Previous research indicates ethnic/race groups are disproportionately affected by chronic pain conditions. However, when considering socioenvironmental factors these disparities are no longer observed. Ethnic/race group differences have also been reported in pain-related brain structure. Given that environmental and sociocultural factors influence biology and health outcomes, this study aimed to investigate possible environmental and sociocultural contributions to structural differences in pain-related brain regions. A total of 147 non-Hispanic black and non-Hispanic white, middle and older aged adults with knee pain in the past month and a brain MRI are included in the analyses. Individuals also provided information specific to health and pain history and environmental and sociocultural resources. In hierarchical multiple regression models, sociocultural and environmental factors explained 6%-37% of the variance in thickness of pain-related brain regions, with seven of the eight brain regions being statistically significant. In the amygdala, hippocampus, insula, bilateral primary somatosensory cortex, and thalamus, ethnicity/race provided an additional 4%-13% of explanatory value. In the rostral/caudal anterior cingulate and dorsolateral prefrontal cortex, ethnicity/race was not a predictor after accounting for environmental, sociocultural, and other demographic measures. Findings inform health disparities research by elucidating the complexity of factors contributing to previously reported ethnicity/race group differences.
Study on machining characteristics of magnetic field assisted micro-EDM with ultrasonic vibration of workpiece
Authors: Yu Peng , Gao Yongcheng , Zhang Xiaodong , Ren Wanfei , Li Yiquan , Xu Jinkai , Yu Huadong
Published: October 2023

Electro discharge machining (EDM) has become one of the most commonly used methods for deep micro hole drilling because of its advantages of no macro force and no limitation of material mechanical properties. However, the characteristics of small discharge energy and narrow discharge gap of deep micro hole drilling by EDM, which leads to the problems of removing erosion debris. The problem of unstable machining process and low efficiency of EDM hinders its application and development. In this paper, the technology of magnetic field assisted micro-EDM with ultrasonic vibration of workpiece is studied to realize high efficiency and quality machining of micro holes with large aspect ratio. The working fluid in the discharge gap will generate alternating pressure driven by the workpiece electrode under ultrasonic vibration, which will promote the discharge debris to be removed from the machining area. The working fluid in the discharge gap will generate alternating pressure driven by the workpiece electrode under ultrasonic vibration, which will promote the discharge debris to be removed from the machining area. Under the influence of electric field and magnetic field, the moving direction of charged particle deflects due to the joint action of Coulomb force and Lorentz force, which prolongs its moving path in the discharge gap. In the study of multi energy field composite machining performance, the most significant factors affecting the material removal rate in the process parameters are ultrasonic amplitude, magnetic induction intensity and peak current, among which the interaction between ultrasonic amplitude and peak current is the most significant. The results also show that carburization and metallization occur simultaneously on the EDM surface, and the hardness of the surface layer of titanium alloy EDM is greater than that of the substrate material. Ultrasonic vibration and magnetic field assisted micro-EDM can reduce the surface residual tensile stress and crack size.
Embryos undergoing delayed second mitosis exhibit a reduced blastocyst formation rate and a lower live birth even if third mitosis was completed on time
Authors: Dong Ran , Ma Shuiying , Li Cheng , Li Qing , zhao haibin , Li Lianjie , Xu Kai , Zhao Hui , Li Mei
Published: October 2023

Background: The phenomenon of day3 (D3) 8-cell embryos derived from day2 (D2) 2-cell embryos can occur in in vitro fertilization (IVF) laboratories. Abnormal cleavage patterns can predict delayed second mitosis. Here, we investigated the developmental potential of these embryos to provide a reference for the selection of embryos for transplantation.
Methods: Embryos were divided into four groups according to cell number on D2 and D3. Group A featured high-quality D2 2-cell embryos that developed into high-quality D3 8-cell embryos; group B featured the same type of embryos as group A except the embryos developed to compaction; group C featured high-quality D2 4-cell embryos that developed into D3 8-cell high quality embryos and group D featured the same type of embryos as group C except the embryos developed to compaction.
Results: The blastocyst formation rate of group A and group B was significantly lower than that of group C (P<0.001). With regards to D3 single embryo transfer (SET) and frozen single blastocyst transfer (SBT), the clinical pregnancy and live birth rates of group A were comparable with those of group C. For D3 double-embryo transfer (DET), the biochemical pregnancy rate, clinical pregnancy rate, and live birth rate, following the combined transfer of embryos from group A and Group C was significantly lower than that when transferring two embryos from group C.
Conclusions: Embryos with delayed second mitosis exhibited a lower blastocyst formation rate and poorer embryo outcomes even though third mitosis was completed on time. Blastocyst culture is useful for selecting blastocysts with a higher probability of live birth for embryos with delayed second mitosis.
Trial registration: This study is retrospective and does not require trial registration.
Clinicopathological analysis of mullerian adenosarcoma of 22 cases and the sequencing of DICER1 mutation
Authors: Yao Xiaohong , He Ying , Wang Wei
Published: October 2023

Background Mullerian adenosarcoma is a rare malignancy the diagnosis and treatment of adenosarcoma is often challenging. We analyzed the clinicopathological features of 22 adenosarcomas and DICER1 hot mutations were screened.
Methods Patients with adenosarcoma registered in the West China the second Hospital from year 2020 to June 2022 were examined. Somatic hotspot mutations in the RNase IIIb domain of DICER1 were screened in 22 adenosarcomas by Sanger sequencing.
Results Only one patient (case16) had DICER1 mutation. All of 22 patients performed total hysterectomy with bilateral salpingo-oophorectomy and 14/22 these patients received adjuvant treatment.
Conclusion No DICER1 hotspot mutations detected.Furthermore, 16/22 presents with early-stage tumors and have favorable outcome, whether overtreatment and adjuvant therapy is benefit for low-risk patients need more definitive data. Conservative management is possible in appropriately selected women with post-operatively intensive monitoring.
Predictive Value of qSOFA Score for Mortality in Older Patients with Dengue Fever : A Retrospective Case-control Study
Authors: Lee Chi-Heng , Ho Yu-Chieh , Hsu Chien-Chin , Lin Hung-Jung , Chung Jui-Yuan , Huang Chien-Cheng
Published: October 2023

Background:Dengue fever (DF) in older patients is associated with higher mortality, but optimal mortality prediction approaches remain unclear. We assessed the utility of the quick Sequential Organ Failure Assessment (qSOFA) as a predictive tool in older DF patients.Methods:We retrospectively included DF patients aged ≥65 years who visited our study hospital between September 1, 2015, and December 31, 2015. Demographics, vital signs, comorbidities, laboratory data, and mortality were collected. Accuracy of qSOFA score ≥2 in predicting 30-day mortality was evaluated.Results:626 older DF patients were recruited (mean age: 74.1 years, nearly equal sex distribution). Mean ± standard deviation of qSOFA score was higher in mortality group vs. survival group (0.6 ± 0.8 vs. 0.1 ± 0,p<0.01). Logistic regression showed qSOFA score ≥2 associated with higher mortality risk (odds ratio: 18.74; 95% confidence interval: 4.37−50.64). Adjusted area under receiver operating characteristic was 0.75, and Hosmer-Lemeshow goodness of fit test was 0.58. Sensitivity, specificity, positive predictive value, and negative predictive value of qSOFA score ≥2 for predicting mortality were 18.5%, 98.7%, 38.5%, and 96.4%, respectively.Conclusion:qSOFA score ≥2 is a simple and specific tool for predicting 30-day mortality in older patients with DF, with high specificity and negative predictive value. It can be used to rule out patients at high risk of mortality.