bluuebunny/crossref_metadata_2025 huggingface dataset:
Annual dynamics of global remote industrial heat sources dataset from 2012 to 2021
Authors: Ma Caihong , Li Tianzhu , Sui Xin , Liao Ruilin , Xie Yanmei , Zhang Pengyu , Wu Mingquan , Wang Dacheng
Published: June 2024

The spatiotemporal distribution of industrial heat sources (IHS) is an important indicator for assessing levels of energy consumption and air pollution. Continuous, comprehensive, dynamic monitoring and publicly available datasets of global IHS (GIHS) are lacking and urgently needed. In this study, we built the first long-term (2012–2021) GIHS dataset based on the density-based spatiotemporal clustering method using multi-sources remote sensing data. A total of 25,544 IHS objects with 19 characteristics are identified and validated individually using high-resolution remote sensing images and point of interest (POI) data. The results show that the user’s accuracy of the GIHS dataset ranges from 90.95% to 93.46%, surpassing other global IHS products in terms of accuracy, omission rates, and granularity. This long-term GIHS dataset serves as a valuable resource for understanding global environmental changes and making informed policy decisions. Its availability contributes to filling the gap in GIHS data and enhances our knowledge of global-scale industrial heat sources.
CaRDS - the statewide California Residential water Demand and Supply open dataset
Authors: Gross Marie-Philine , Escriva-Bou Alvar , Porse Erik , Cominola Andrea
Published: June 2024

As water scarcity becomes the new norm in the Western United States, states such as California have increased their efforts to improve water resilience. Achieving water security under climate change, population growth, and urbanization requires an integrated multi-sectoral approach, where adaptation strategies combine supply and demand management interventions. Yet, most studies consider supply-side and demand-side management strategies separately. Water conservation efforts are mainly driven by policy requirements and publicly available data to assess the effectiveness of demand- and supply-side management policies is often hard to find and unstructured. Here we present CaRDS - the statewide California Residential water Demand and Supply open dataset. CaRDS encompasses nine years (2013-2021) of monthly water supply and demand time series for 404 water suppliers in California, USA, compiled from different open-access data sources. Access to detailed temporal and spatial water supply operations and demands at the state-level can be useful to researchers and practitioners to realize applications such as evaluating the effectiveness of water conservation policies and discovering regional differences in water resilience measures.
Transcriptomic annotation of the Chungtien schizothoracin (Ptychobarbus chungtienensis) using Iso-seq and RNA-seq data
Authors: Gao Zhendong , Chong Yuqing , Lu Ying , Ma Shiguang , Wang Zhen , Hong Jieyun , Wu Jiao , Li Mengfei , Xi Dongmei , Deng Weidong
Published: June 2024

The Chungtien schizothoracin (Ptychobarbus chungtienensis), an endangered fish species endemic to the Zhongdian Plateau, remains underexplored in terms of transcriptomic sequencing. This investigation used tissues from five distinct organs (heart, liver, spleen, kidney, and brain) of the Chungtien schizothoracin for PacBio Iso-seq and RNA-seq analyses, yielding a repertoire of 16,598 full-length transcripts spanning lengths from 363 bp to 7,157 bp. Gene family clustering and phylogenetic analysis encompassed a comprehensive set of 13 fish species, all of which were cyprinids, including the zebrafish and the examined species Ptychobarbus chungtienensis. Moreover, the identification of long non-coding RNAs (lncRNAs) and coding sequences was accomplished across all five tissues. Comprehensive analyses of gene expression profiles and differentially expressed genes among the above five tissues were performed. In summary, the obtained full-length transcripts and detailed gene expression profiles of the Chungtien schizothoracin tissues furnish crucial expression data and genetic sequences, laying the groundwork for future investigations and fostering a holistic comprehension of the adaptive mechanisms inherent in the Chungtien schizothoracin under various conditions.
Focused reservoir characterization: analysis of selected sand units using well log and 3-D seismic data in 'Kukih' field, Onshore Niger Delta, Nigeria
Authors: Fagbemi Olufisayo Ibukun , Olayinka Abel Idowu , Oladunjoye Michael Adeyinka , Edigbue Paul Irikefe
Published: June 2024

This study focuses on the comprehensive reservoir characterization of the ‘Kukih’ Field within the onshore northeastern Niger Delta region, Nigeria. The absence of its detailed description with delineated reservoir properties, lateral continuity, and their use to identify potential reservoir quality and heterogeneity necessitated this study. Integrating well log and 3D seismic data, the investigation aims to elucidate reservoir properties, lithofacies, and depositional environments to unravel hydrocarbon potential. The geological setting, encompassing the Agbada Formation of Early and Middle Miocene age, is scrutinized through detailed geologic analysis. Petrophysical evaluation of four well logs (Kukih-1, Kukih-2, Kukih-3, and Kukih-4) facilitated the determination of key parameters such as shale volume, effective porosity, and water saturation. Seismic interpretation further enriched the structural characterization of the field. Results showcase three predominant reservoir sands (A, B, and C) with distinct lithofacies and thickness variations. Effective porosity ranges from Fair to Excellent, with permeability exhibiting high values for hydrocarbon reservoir potential. Water saturation trends, lithofacies distributions, and structural features were illuminated through iso-parametric maps and seismic analyses. Depositional environments were inferred through facies analysis, revealing the presence of funnel-, cylinder-, and bell-shaped successions that hint at intricate marine sedimentary processes. Challenges owing to limited core data were acknowledged, and the integration of methodologies emerged as a pivotal strategy for enhanced reservoir understanding. This study underscores the ‘Kukih’ Field's hydrocarbon potential, accentuating the significance of multidisciplinary approaches in deciphering complex reservoir systems. In light of the petrophysical analysis derived from the well logs and the identification of structural highs through the structural maps, this study recommends the drilling of unexplored zones exhibiting promising structural characteristics.
In-vitro and in-silico analyses of the thrombolytic potential of green kiwifruit
Authors: Pinontoan Reinhard , Purnomo Jonathan Suciono , Avissa Elvina Bella , Tanojo Jessica Pricilla , Djuan Moses , Vidian Valerie , Samantha Ariela , Jo Juandy , Steven Eden
Published: June 2024

Cardiovascular diseases (CVDs), mainly caused by thrombosis complications, are the leading cause of mortality worldwide, making the development of alternative treatments highly desirable. In this study, the thrombolytic potential of green kiwifruit (Actinidia deliciosa cultivar Hayward) was assessed using in-vitro and in-silico approaches. The crude green kiwifruit extract demonstrated the ability to reduce blood clots significantly by 73.0 ± 1.12% (P < 0.01) within 6 h, with rapid degradation of Aα and Bβ fibrin chains followed by the γ chain in fibrinolytic assays. Molecular docking revealed six favorable conformations for the kiwifruit enzyme actinidin (ADHact) and fibrin chains, supported by spontaneous binding energies and distances. Moreover, molecular dynamics simulation confirmed the binding stability of the complexes of these conformations, as indicated by the stable binding affinity, high number of hydrogen bonds, and consistent distances between the catalytic residue Cys25 of ADHact and the peptide bond. The better overall binding affinity of ADHact to fibrin chains Aα and Bβ may contribute to their faster degradation, supporting the fibrinolytic results. In conclusion, this study demonstrated the thrombolytic potential of the green kiwifruit-derived enzyme and highlighted its potential role as a natural plant-based prophylactic and therapeutic agent for CVDs.
Exploring the twin potential of nanostructured TiO2:SeO2 as a promising visible light photocatalyst and selective fluorosensing platform
Authors: Sharma Aarti , Sharotri Nidhi , Kandwal Pankaj , Sharma Rakesh Kumar , Sud Dhiraj , Rai Ritu , Hnydiuk-Stefan Anna
Published: June 2024

The present work describes the development of TiO2/SeO2 nanostructure as a potential candidate for visible light photocatalysis as well as selective fluorophore for the sensing of picric acid. The obtained nanostructure consists of uniform globular nanoparticles having approximate size of 170 nm and possess an optical band gap of 2.33 eV with absorption maxima at 473 nm. The photocatalyst was able to achieve 90.34% degradation efficiency for 2, 4-dichlorophenol (2,4-DCP) with rate constant of 0.0046 min−1 in the visible region. Further the nanostructure was able to serve as a selective fluorophore for sensing of Picric acid portraying more than 95% of fluorescence quenching when the concentration of PA is 10–4 M. Theoretical calculations indicate the interaction of organic pollutants with the nanostructure and reveal that both picric acid (− 66.21 kcal/mol) and 2,4-DCP (− 12.31 kcal/mol) possess more negative binding energy values demonstrating a strong interaction of both with the nanostructure, making it suitable for the degradation as well as sensing of organic pollutants. Thus this study explains the potential of prepared catalyst for waste water treatment.
PDE1B, a potential biomarker associated with tumor microenvironment and clinical prognostic significance in osteosarcoma
Authors: Chen Qingzhong , Xing Chunmiao , Zhang Qiaoyun , Du Zhijun , Kong Jian , Qian Zhongwei
Published: June 2024

PDE1B had been found to be involved in various diseases, including tumors and non-tumors. However, little was known about the definite role of PDE1B in osteosarcoma. Therefore, we mined public data on osteosarcoma to reveal the prognostic values and immunological roles of the PDE1B gene. Three osteosarcoma-related datasets from online websites were utilized for further data analysis. R 4.3.2 software was utilized to conduct difference analysis, prognostic analysis, gene set enrichment analysis (GSEA), nomogram construction, and immunological evaluations, respectively. Experimental verification of the PDE1B gene in osteosarcoma was conducted by qRT-PCR and western blot, based on the manufacturer's instructions. The PDE1B gene was discovered to be lowly expressed in osteosarcoma, and its low expression was associated with poor OS (all P < 0.05). Experimental verifications by qRT-PCR and western blot results remained consistent (all P < 0.05). Univariate and multivariate Cox regression analyses indicated that the PDE1B gene had independent abilities in predicting OS in the TARGET osteosarcoma dataset (both P < 0.05). GSEA revealed that PDE1B was markedly linked to the calcium, cell cycle, chemokine, JAK STAT, and VEGF pathways. Moreover, PDE1B was found to be markedly associated with immunity (all P < 0.05), and the TIDE algorithm further shed light on that patients with high-PDE1B expression would have a better immune response to immunotherapies than those with low-PDE1B expression, suggesting that the PDE1B gene could prevent immune escape from osteosarcoma. The PDE1B gene was found to be a tumor suppressor gene in osteosarcoma, and its high expression was related to a better OS prognosis, suppressing immune escape from osteosarcoma.
Enhancement of aerodynamic performance of axial compressors utilizing natural aspiration through optimized casing circumferential slot
Authors: Nejad Peyman Ghashghaie , Zenouz Reza Taghavi
Published: June 2024

This paper presents results of aerodynamic enhancement of axial compressors utilizing optimum natural aspiration through a circumferential slot made within the casing wall upstream the rotor blades row. The method of investigation is based on numerical simulation of flow field. Geometries of the slot walls were optimized to find the maximum stall margin and pressure ratio of the compressor. The optimum case is accompanied by boosting more momentum within the blades tip region through the slot. Consequently, tip leakage vortex flow weakens and compressor stability margin increases. Final results showed that in comparison to the untreated casing, the optimum geometry of the slot causes the total pressure ratio and stall margin to increase by 4.2% and 3%, respectively. This state-of-the-art technique is simple and economic which can be easily implemented in practical cases while the compressor is exposed to commencement of flow instabilities in the forms of the rotating stall or surge phenomena.
Intraluminal oxygen can keep small bowel mucosa intact in a segmental ischemia model
Authors: Trentadue Guido , Mensink Peter B. F. , Kruse Claudius , Reszel Bernward , Kats-Ugurlu Gursah , Blokzijl Tjasso , Haveman Jan Willem , Faber Klaas Nico , Dijkstra Gerard , Hölscher Uvo M. , Kolkman Jeroen J. , Knichwitz Gisbert
Published: June 2024

Intestinal preservation for transplantation is accompanied by hypoperfusion with long periods of ischemia with total blood cessation and absolute withdrawal of oxygen leading to structural damage. The application of intraluminal oxygen has been successfully tested in small-animal series during storage and transport of the organ but have been so far clinically unrelatable. In this study, we tested whether a simple and clinically approachable method of intraluminal oxygen application could prevent ischemic damage in a large animal model, during warm ischemia time. We utilised a local no-flow ischemia model of the small intestine in pigs. A low-flow and high-pressure intraluminal oxygen deliverance system was applied in 6 pigs and 6 pigs served as a control group. Mucosal histopathology, hypoxia and barrier markers were evaluated after two hours of no-flow conditions, in both treatment and sham groups, and in healthy tissue. Macro- and microscopically, the luminal oxygen delivered treatment group showed preserved small bowel’s appearance, viability, and mucosal integrity. A gradual deterioration of histopathology and barrier markers and increase in hypoxia-inducible factor 1-α expression towards the sites most distant from the oxygen application was observed. Intraluminal low-flow, high oxygen delivery can preserve the intestinal mucosa during total ischemia of the small intestine. This finding can be incorporated in methods to overcome small bowel ischemia and improve intestinal preservation for transplantation.
Effects of empagliflozin on reproductive system in men without diabetes
Authors: Kosinski Christophe , Papadakis Georgios E. , Salamin Olivier , Kuuranne Tiia , Nicoli Raul , Pitteloud Nelly , Zanchi Anne
Published: June 2024

Sodium-glucose cotransporter (SGLT) 2 inhibition is a well-known target for the treatment of type 2 diabetes, renal disease and chronic heart failure. The protein SGLT2 is encoded by SLC5A2 (Solute Carrier Family 5 Member 2), which is highly expressed in renal cortex, but also in the testes where glucose uptake may be essential for spermatogenesis and androgen synthesis. We postulated that in healthy males, SGLT2 inhibitor therapy may affect gonadal function. We examined the impact on gonadal and steroid hormones in a post-hoc analysis of a double-blind, randomized, placebo-controlled research including 26 healthy males who were given either placebo or empagliflozin 10 mg once daily for four weeks. After one month of empagliflozin, there were no discernible changes in androgen, pituitary gonadotropin hormones, or inhibin B. Regardless of BMI category, the administration of empagliflozin, a highly selective SGLT2 inhibitor, did not alter serum androgen levels in men without diabetes. While SGLT2 is present in the testes, its inhibition does not seem to affect testosterone production in Leydig cells nor inhibin B secretion by the Sertoli cells.
Exploring mesoscopic mass transport effects on electrocatalytic selectivity
Authors: Heenen Hendrik H. , Pillai Hemanth S. , Reuter Karsten , Bukas Vanessa J.
Published: June 2024

Electrocatalytic selectivity is often discussed at the atomic level on the basis of the active site, while ignoring more subtle effects of mesoscopic mass transport. Here we show how transport controls selectivity through the exchange of surface-bound reaction intermediates between the electrode and bulk electrolyte. We argue that the arising kinetic competition changes with the catalyst’s surface area and can become relevant for technologically important reactions including, for example, different products during the electrochemical CO2 reduction on Cu-based catalysts. Combining microkinetic and transport modelling in a multi-scale approach, we specifically explore and quantify this effect for various showcase examples in the experimental literature. Despite its simplicity, our model correctly reproduces selectivity trends with respect to catalyst roughness on all meso-, micro- and atomic scales. The resulting insight provides an alternative or, at least, complementary explanation to changes in electrocatalytic selectivity that have otherwise been attributed to nano-structuring of active sites or electronic effects due to doping or alloying.
Tunable acoustic vortex generation by a compact rotating disk
Authors: Li Rui , Liu Chunxia , Wang Linbo , Ma Chengzhi , Wu Jiu hui , Ma Fuyin
Published: June 2024

Acoustic vortices (AVs) carry orbital angular momentum (OAM), showing great promise in advancing communication, biomedicine, and metrology. An ideal OAM generation method that realizes the tunability of AV topological charge and working frequency in a compact way is strongly desired. Here, we utilize aerodynamic dipole sources from a rotating disk to generate AV. This method generates AVs with different topological charges through the interference of these dipole sources at the angular rotation frequency and its multiples. These AVs exhibit high purity, and their three-dimensional characteristics are explored. Furthermore, our experiment demonstrates that the generated AVs significantly enhance the sound field amplitude at their working frequency, which is the product of the topological charge and angular frequency. The results also verify that this amplitude enhancement effect is positively correlated with the AV’s stability and achieves the contactless detection of disk rotation information. The demonstrated method provides expanded versatility for OAM-based applications.
Quantum double lock-in amplifier
Authors: Chen Sijie , Zhuang Min , Fang Ruihuang , Chen Yun , Han Chengyin , Lu Bo , Huang Jiahao , Lee Chaohong
Published: June 2024

Quantum lock-in amplifiers have been proposed to extract an alternating signal from a strong noise background. However, due to the typical target signal has unknown initial phase, it is challenging to extract complete information about the signal’s amplitude, frequency, and initial phase. Here, we present a general protocol for achieving a quantum double lock-in amplifier by employing two quantum mixers operating under orthogonal pulse sequences. To demonstrate the practical implementation, we discuss the experimental feasibility using a five-level double-Λ coherent population trapping system with Rb atoms. Here, each Λ structure acts as a quantum mixer, and two applied dynamical decoupling sequences serve as orthogonal reference signals. Notably, the system significantly reduces the total measurement time by nearly half and mitigates time-dependent systematic errors compared to conventional two-level systems. Furthermore, our quantum double lock-in amplifier is robust against experimental imperfections. This study establishes a pathway to alternating signal measurement, thereby facilitating the development of practical quantum sensing technologies.
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes
Authors: Kizilkaya Hüsün S. , Sørensen Kimmie V. , Madsen Jakob S. , Lindquist Peter , Douros Jonathan D. , Bork-Jensen Jette , Berghella Alessandro , Gerlach Peter A. , Gasbjerg Lærke S. , Mokrosiński Jacek , Mowery Stephanie A. , Knerr Patrick J. , Finan Brian , Campbell Jonathan E. , D’Alessio David A. , Perez-Tilve Diego , Faas Felix , Mathiasen Signe , Rungby Jørgen , Sørensen Henrik T. , Vaag Allan , Nielsen Jens S. , Holm Jens-Christian , Lauenborg Jeannet , Damm Peter , Pedersen Oluf , Linneberg Allan , Hartmann Bolette , Holst Jens J. , Hansen Torben , Wright Shane C. , Lauschke Volker M. , Grarup Niels , Hauser Alexander S. , Rosenkilde Mette M.
Published: June 2024

Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes1. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) activation have resulted in similar clinical outcomes, as demonstrated by the GIPR–GLP-1R co-agonist tirzepatide2 and AMG-133 (ref. 3) combining GIPR antagonism with GLP-1R agonism. This underlines the importance of a better understanding of the GIP system. Here we show the necessity of β-arrestin recruitment for GIPR function, by combining in vitro pharmacological characterization of 47 GIPR variants with burden testing of clinical phenotypes and in vivo studies. Burden testing of variants with distinct ligand-binding capacity, Gs activation (cyclic adenosine monophosphate production) and β-arrestin 2 recruitment and internalization shows that unlike variants solely impaired in Gs signalling, variants impaired in both Gs and β-arrestin 2 recruitment contribute to lower adiposity-related traits. Endosomal Gs-mediated signalling of the variants shows a β-arrestin dependency and genetic ablation of β-arrestin 2 impairs cyclic adenosine monophosphate production and decreases GIP efficacy on glucose control in male mice. This study highlights a crucial impact of β-arrestins in regulating GIPR signalling and overall preservation of biological activity that may facilitate new developments in therapeutic targeting of the GIPR system.
Low mercury concentrations in a Greenland glacial fjord attributed to oceanic sources
Authors: Lindeman M. R. , Straneo F. , Adams H. M. , Nelson M. J. S. , Schartup A. T.
Published: June 2024

As the role of the Greenland Ice Sheet in the Arctic mercury (Hg) budget draws scrutiny, it is crucial to understand mercury cycling in glacial fjords, which control exchanges with the ocean. We present full water column measurements of total mercury (THg) and methylmercury (MeHg) in Sermilik Fjord, a large fjord in southeast Greenland fed by multiple marine-terminating glaciers, whose circulation and water mass transformations have been extensively studied. We show that THg (0.23-1.1 pM) and MeHg (0.02-0.17 pM) concentrations are similar to those in nearby coastal waters, while the exported glacially-modified waters are relatively depleted in inorganic mercury (Hg(II)), suggesting that inflowing ocean waters from the continental shelf are the dominant source of mercury species to the fjord. We propose that sediments initially suspended in glacier meltwaters scavenge particle-reactive Hg(II) and are subsequently buried, making the fjord a net sink of oceanic mercury.
Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis
Authors: Eberhard Daniel , Balkenhol Sydney , Köster Andrea , Follert Paula , Upschulte Eric , Ostermann Philipp , Kirschner Philip , Uhlemeyer Celina , Charnay Iannis , Preuss Christina , Trenkamp Sandra , Belgardt Bengt-Frederik , Dickscheid Timo , Esposito Irene , Roden Michael , Lammert Eckhard
Published: June 2024

Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, increases worldwide and associates with type 2 diabetes and other cardiometabolic diseases. Here we demonstrate that Sema3a is elevated in liver sinusoidal endothelial cells of animal models for obesity, type 2 diabetes and MASLD. In primary human liver sinusoidal endothelial cells, saturated fatty acids induce expression of SEMA3A, and loss of a single allele is sufficient to reduce hepatic fat content in diet-induced obese mice. We show that semaphorin-3A regulates the number of fenestrae through a signaling cascade that involves neuropilin-1 and phosphorylation of cofilin-1 by LIM domain kinase 1. Finally, inducible vascular deletion of Sema3a in adult diet-induced obese mice reduces hepatic fat content and elevates very low-density lipoprotein secretion. Thus, we identified a molecular pathway linking hyperlipidemia to microvascular defenestration and early development of MASLD.
Back to basics for the IPCC: applying lessons from AR6 to the Seventh Assessment Cycle
Authors: Slade Raphael , Pathak Minal , Connors Sarah , Tignor Melinda , Okem Andrew Emmanuel , Leprince-Ringuet Noëmie
Published: June 2024

The Intergovernmental Panel on Climate Change (IPCC) has been producing influential reports for over 35 years. As the IPCC’s Seventh Assessment Report (AR7) cycle begins, we offer our perspective as former members of the IPCC Technical Support Units from Working Groups I, II & III, and the Synthesis Report on lessons learned during the Sixth Assessment Report (AR6) cycle. We identify three broad issues that, if addressed, could reinforce and sustain the IPCC in continuing its mission to comprehensively assess the scientific understanding of human-induced climate change. These are the imperative to ensure balanced representation, the importance of author recognition, and the need for improved institutional memory. Our recommendations include addressing skill and training needs, tackling barriers to participation particularly for Global South authors, and ensuring all contributors receive appropriate recognition for their efforts. We focus, in particular, on feasible incremental changes that could be implemented during AR7 without major changes to the underlying procedures that require approval by the 195 member governments that make up the IPCC.
The endoplasmic reticulum connects to the nucleus by constricted junctions that mature after mitosis
Authors: Bragulat-Teixidor Helena , Ishihara Keisuke , Szücs Gréta Martina , Otsuka Shotaro
Published: June 2024

Junctions between the endoplasmic reticulum (ER) and the outer membrane of the nuclear envelope (NE) physically connect both organelles. These ER–NE junctions are essential for supplying the NE with lipids and proteins synthesized in the ER. However, little is known about the structure of these ER–NE junctions. Here, we systematically study the ultrastructure of ER–NE junctions in cryo-fixed mammalian cells staged in anaphase, telophase, and interphase by correlating live cell imaging with three-dimensional electron microscopy. Our results show that ER–NE junctions in interphase cells have a pronounced hourglass shape with a constricted neck of 7–20 nm width. This morphology is significantly distinct from that of junctions within the ER network, and their morphology emerges as early as telophase. The highly constricted ER–NE junctions are seen in several mammalian cell types, but not in budding yeast. We speculate that the unique and highly constricted ER–NE junctions are regulated via novel mechanisms that contribute to ER-to-NE lipid and protein traffic in higher eukaryotes.
ABIN1 is a negative regulator of effector functions in cytotoxic T cells
Authors: Janusova Sarka , Paprckova Darina , Michalik Juraj , Uleri Valeria , Drobek Ales , Salyova Eva , Chorfi Louise , Neuwirth Ales , Andreyeva Arina , Prochazka Jan , Sedlacek Radislav , Draber Peter , Stepanek Ondrej
Published: June 2024

T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by the T-cell antigen receptors (TCR) and co-stimulatory or inhibitory receptors. The molecular regulation of these complex signaling networks is still incompletely understood. Here, we identify the adaptor protein ABIN1 as a component of the signaling complexes of GITR and OX40 co-stimulation receptors. T cells lacking ABIN1 are hyper-responsive ex vivo, exhibit enhanced responses to cognate infections, and superior ability to induce experimental autoimmune diabetes in mice. ABIN1 negatively regulates p38 kinase activation and late NF-κB target genes. P38 is at least partially responsible for the upregulation of the key effector proteins IFNG and GZMB in ABIN1-deficient T cells after TCR stimulation. Our findings reveal the intricate role of ABIN1 in T-cell regulation.
Electricity-driven, oxidative C–H selenylative and tellurylative annulation of N-(2-alkynyl)anilines: sustainable synthesis of 3-selanyl/tellanylquinolines
Authors: Naresh Ainala , Keerthana H. Sai , Mukherjee Nilanjana , Chatterjee Tanmay
Published: June 2024

A metal- and oxidant-free, electricity-driven C–H selenylative and tellurylative annulation of N-(2-alkynyl)anilines with diorganyl dichalcogenides is developed to access 3-chalcogenylquinolines.
Organocatalysis as an enabling tool for enantioselective ring-opening reactions of cyclopropanes
Authors: Reyes Efraim , Uria Uxue , Prieto Liher , Carrillo Luisa , Vicario Jose L.
Published: June 2024

In this article we disclose our contributions to use of cyclopropanes as unconventional reagents for the development of enantioselective transformations under different organocatalytic activation manifolds for the synthesis of chiral building blocks.
Ordered immobilization of serine proteases enabled by a linchpin directed modification platform
Authors: Rawale Dattatraya Gautam , Gupta Mrityunjay , Thakur Kalyani , V. Ragendu , Rai Vishal
Published: June 2024

Here, we demonstrate a chemical method for precise single-site engineering of trypsin and α-chymotrypsin. In turn, it enables highly efficient heterogeneous proteolytic digestion.
Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach
Authors: Alfano Antonella Ilenia , Smyth Megan , Wharry Scott , Moody Thomas S. , Nuño Manuel , Butters Chris , Baumann Marcus
Published: June 2024

This study highlights the application of a photo-CSTR cascade for the scalable and selective generation of pyrazolines under heterogeneous conditions.
Characterization of changes in the electronic structure of platinum sub-nanoclusters supported on graphene induced by oxygen adsorption
Authors: Hirase Hinoki , Iida Kenji , Hasegawa Jun-ya
Published: June 2024

The characteristics of changes in the electronic structure of a platinum sub-nanocluster caused by oxygen adsorption is elucidated by analyzing the integrated local density of states.
Effect of doping and defects on the electronic properties of MoS2/WSe2 bilayer heterostructure: a first-principles study
Authors: Wang Xingliang , Zhao Guijuan , Lv Xiurui , Zhao Mingyang , Wei Wanting , Liu Guipeng
Published: June 2024

By using first principles calculations, we theoretically investigate the effect of doping and defects on the electronic properties of MoS2/WSe2 bilayer van der Waals heterostructure.
DrugPose: benchmarking 3D generative methods for early stage drug discovery
Authors: Jocys Zygimantas , Grundy Joanna , Farrahi Katayoun
Published: June 2024

Molecule generation in 3D space has gained attention in the past few years.
Surface amorphization and functionalization of a NiFeOOH electrocatalyst for a robust seawater electrolyzer
Authors: Wang Hao , Jiang Nannan , Huang Bing , Yu Qiangmin , Guan Lunhui
Published: June 2024

Heteroatom doping to accelerate NiFeOOH surface amorphization with a surface functionalization strategy for sustainable solar-driven seawater splitting.
Effect of lactic acid fermentation on the physico-chemical, functional, and antioxidant properties, and in vitro protein digestibility of malted ragi (Eleusine coracana L.)
Authors: Dev Rahul , Bhatt Shriya , Gupta Mahesh
Published: June 2024

Ragi is a widely recognized “Shree Anna” that should be included in diets to augment food diversity and security amid climate change challenges.
Correction: Administering Lactiplantibacillus fermentum F6 decreases intestinal Akkermansia muciniphila in a dextran sulfate sodium-induced rat colitis model
Authors: He Qiuwen , Zhang Tao , Zhang Weiqin , Feng Cuijiao , Kwok Lai-Yu , Zhang Heping , Sun Zhihong
Published: June 2024

Correction for ‘Administering Lactiplantibacillus fermentum F6 decreases intestinal Akkermansia muciniphila in a dextran sulfate sodium-induced rat colitis model’ by Qiuwen He et al., Food Funct., 2024, 15, 5882–5894, https://doi.org/10.1039/d4fo00462k.
A general platform for phosphorylation reactions enabled by photoinduced palladium catalysis
Authors: Zhang Yu-Jie , Wang Xue-Song , Cao Jian , Xu Li-Wen
Published: June 2024

A photoinduced palladium-catalyzed generation of phosphorus radicals using Cl–phosphine oxides and Cl–phosphates is realized to achieve formal P-Heck reaction, C–H phosphinylation of heteroaromatics and difunctionalization of alkenes.
Visible-light-induced aerobic oxidation of alcohols to aldehydes/ketones via solvated dispersion intermediates
Authors: Lei Wenlong , Liu Runze , Li Rengui , Liu Yan , Li Can
Published: June 2024

Visible-light-induced fast and selective aerobic oxidation of alcohols to aldehydes/ketones with HBr as a mediator in ethyl acetate enables high selectivity (up to 99%) and high conversion (up to 97%) for a broad range of alcohols.
Ultrasensitive quantification of PD-L1+ extracellular vesicles in melanoma patient plasma using a parallelized high throughput droplet digital assay
Authors: Shen Hanfei , Atiyas Yasemin , Yang Zijian , Lin Andrew A. , Yang Jingbo , Liu Diao , Park Juhwan , Guo Wei , Issadore David A.
Published: June 2024

We develop a high-throughput droplet-based extracellular vesicle analysis (DEVA) assay for ultrasensitive quantification of EVs in plasma that are positive for both PD-L1 and tetraspanins.
Synthesis and in vitro evaluation of novel amino-phenylmethylene-imidazolone 5-HT2A receptor antagonists
Authors: Dwulet Gregory E.
Published: June 2024

This study investigates the 5-HT2A receptor-binding properties of a series of novel compounds with an amino-phenylmethylene-imidazolone (APMI) core structure.
Designing N, P-doped graphene surface-supported Mo single-atom catalysts for efficient conversion of nitrogen into ammonia: a computational guideline
Authors: Khedr Ghada E. , Fawzy Samar M. , Sharafeldin Icell M. , Allam Nageh K.
Published: June 2024

Tuning the surroundings of single-atom catalysts (SACs) has been recognized as a successful approach to enhance their electrocatalytic efficiency.
Csp3–H bond activation mediated by a Pd(ii) complex under mild conditions
Authors: Na Hanah , Wessel Andrew J. , Kim Seoung-Tae , Baik Mu-Hyun , Mirica Liviu M.
Published: June 2024

A pentadentate pyridinophane ligand is reported, along with a palladacycle product generated via Csp3–H bond activation under mild conditions.
Poisoning resistance: challenges for hydrogen storage alloys toward engineering applications
Authors: Gu Jing , Yao Zhendong , Gao Ge , Wang Yijing , Liu Min , Chen Miaogen , Li Chao , Fan Meiqiang , Xiao Xuezhang , Chen Lixin
Published: June 2024

Based on the relationship between keywords, six typical hydrogen storage alloys in the field of poisoning were investigated.
Recent progress in Mott–Schottky junction electrocatalysts for the pH-universal hydrogen evolution reaction
Authors: Zhang Huaming , Li Rong , Humayun Muhammad , Huang Zhihan , Fu Yanjun , Cao Yulin , Duan Junhong , Attia Yasser A. , Wang Chundong
Published: June 2024

Pathways for the hydrogen evolution reaction under acidic and alkaline (or neutral) conditions.
Vacancy-and doping-mediated electronic and magnetic properties of PtSSe monolayer towards optoelectronic and spintronic applications
Authors: Nguyen Duy Khanh , Ponce-Pérez R. , Guerrero-Sanchez J. , Hoat D. M.
Published: June 2024

The defect- and doping-assisted functionalization of a stable Janus PtSSe monolayer towards spintronic applications is systematically investigated.
Facile synthesis of magnetic intelligent sensors for the pH-sensitive controlled capture of Cr(vi)
Authors: Hu Peixin , Lu Hechao , He Qinting , Ren Fang , Wu Juan , Jiang Wei
Published: June 2024

In this work, intelligent pH-sensitive sensors (Fe3O4/RhB@PAM) for Cr(vi) detection were successfully synthesized based on polyacrylamide (PAM) and Rhodamine B (RhB) co-modified Fe3O4 nanocomposites.
Dry reforming of HCs (methane, ethane, and propane) over a 40Ni0.75(Ce1−xFex)0.25/Al2O3 catalyst: a comparative study
Authors: Rajput Akanksha Singh , Das Taraknath
Published: June 2024

Dry reforming of methane, ethane, and propane to synthesis gas using the same catalyst.
Stability of giant dielectric properties in co‐doped rutile TiO2 ceramics under temperature and humidity
Authors: Wongsricha Jurimart , Harnchana Viyada , Srepusharawoot Pornjuk , Phromviyo Nutthakritta , Moontragoon Pairot , Thongbai Prasit
Published: June 2024

This research investigated the influence of temperature and humidity on the giant dielectric (GD) properties of 1% indium tin oxide and 1% Ta2O5 co‐doped TiO2 ceramics sintered at different temperatures. A single phase of rutile TiO2 was obtained in all sintered samples. The mean grain size increased with higher sintering temperatures, resulting in ceramics with a relative density exceeding 98%. A uniform dispersion of dopants and major elements was achieved. Remarkably, the dielectric constant increased significantly from 2 × 103 to 3.7 × 104 with a rising sintering temperature, primarily due to the enlarged grain size. Concurrently, the authors observed low loss tangents, ranging from tanδ≈0.016 to 0.024 at 1 kHz. Slight variations in the dielectric constant were observed with temperature from room temperature up to 210°C, while maintaining remarkably low tanδ. The GD properties were attributed to space charge polarisation at internal interfaces and defect dipoles. Further research explored the impact of environmental conditions on dielectric properties. Remarkably, the ceramics exhibited minimal capacitance variations of less than 10% within the relative humidity range of 30%–95% and temperatures from 15 to 85°C, indicating excellent dielectric stability.
PPMLM direct thrust force control based on iterative learning high‐order improved model free adaptive control
Authors: Wang Xiuping , Yao Shunyu , Qu Chunyu
Published: June 2024

A high‐order improved model free adaptive control method based on iterative learning is designed to address the problem that primary permanent magnet linear motor has poor control performance, susceptibilities to load disturbances and other nonlinear disturbances during operation. The proposed algorithm adopts an improved dynamic linearization model and high‐order pseudo partial derivative estimation algorithm, which improves the data utilization of the data‐driven control algorithm, makes the algorithm better to describe the dynamic behaviour of the primary permanent magnet linear motor direct thrust force control system and improves the speed tracking accuracy and anti‐interference ability of the system. In addition, iterative learning control was adopted as feedforward compensation to further improve the control performance of the system and the stability of the closed‐loop system was analysed analytically. The simulation results show that the proposed control algorithm can improve the control accuracy of the system and suppress load disturbances and other nonlinear disturbances.
Enzymatic processing as a tool for increasing the biological value of pumpkin puree
Authors: Rozhnov Evgeny , Shkolnikova Marina , Lazarev Vladimir
Published: June 2024

The purpose of the article is to obtain a puree with a high content of carotenoids from the pulp of the “Rossiyanka” pumpkin by destroying the polymers of the raw material using the enzyme preparations Amylorizin and Protozyme (water:preparation ratio – 10:1). Enzymeolysis of the native puree was carried out in a laboratory reactor with a volume of 2 dm3 at a temperature of 70±2 °C. It was being continuously stirred for 60 minutes, then dried to a moisture content of 5%. The effectiveness of enzymatic treatment was assessed by carotenoid content. It has been established that complete hydrolysis of pumpkin pulp starch is ensured by a 60-minute treatment with a multienzyme composition containing 25 U/g of Amylorizin, 100 U/g and 150 U/g of Protozym, which makes it possible to increase the content of ß -carotene by 8.4-10.3% and improve the organoleptic characteristics of the resulting puree: the texture becomes uniform without any graininess typical for the native puree. It makes the appearance and palatability of the puree more attractive, there is no flavor of raw vegetables, pleasant and harmonious aroma and taste of steamed pumpkin prevail.
RETRACTED: Possibilities and Importance of using artificial intelligence technologies in smart grid systems
Authors: Khasanov Doston , Khujamatov Halimjon , Jumanov Khakberdi , Rakhimov Abdugofur
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: On the theoretical study of the phenomena of electromagnetism with variable core parameters
Authors: Yusupova Anora , Aliyev Ibratjon , Kholmatov Erkinjon , Abduraxmonov Sultonali
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Prospects of using working water reservoirs in the irrigation mode in the development of the hydro energy industry
Authors: Arifjanov Aybek , Xoshimov Sardor , Babajanov Farrukh , Matkaziyev Dilshod , Komilov Sheroz
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Implementing energy-saving technologies in hot asphalt production: A comprehensive review
Authors: Sarmonov Azizbek , Rustamov Kamoliddin
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: The modeling of the tectonic state of the angren coal mine Area before mining operations
Authors: Sayyidkosimov Sayyidjabbor , Sokhibov Isomiddin , Anarbayev Khalimjon
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Conceptual Development of resorts in Ukraine on the basis of barrier-free access under martial law
Authors: Sazonets Igor , Vivsyannyk Oleh , Babiak Olena , Burachyk Andrii
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Globalization and local service businesses: A study of small business contributions to service industry development
Authors: Nasimov Dilmurod , Yekimov Sergey , Arabov Nurali , Bozorov Berdimurod , Ulugmuradova Nodira , Tukhliev Bakhtiyor
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Analyzing influential factors on healthcare expenditures
Authors: Jakhongirov Ilimdorjon , Mahmudov Nasir , Abdurakhmanova Shokhida , Ruzikulova Dilnoza , Dexkanov Sherzod
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Architectural solutions of "Government Services Center" buildings in foreign countries and project proposals suitable for the conditions of Uzbekistan
Authors: Bekturdiev Izzat , Khojaniozov Shakir , Atamuratov Adilbek , Sobirov Azamat
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Assessment of the effect of traffic safety on the on-street parking in case of Uzbekistan
Authors: Mamaev G. , Kulmuradov D. , Yuldoshev B.
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Quality improvement at public catering enterprises
Authors: Petržílka Slavibor , Nianko Viktoriia , Yarmoliuk Olena , Petko Stanislav , Oleksenko Roman
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: The human factor in the disappearance of central Asian tigers
Authors: Orziyev Mahmud , Kucharov Jamshid , Egamberdiyev Faxriddin
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Species composition of non-hunting fish in Bukhara region
Authors: Rayimov A.R. , Qoilova M.D. , Raximov J.R.
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Dynamics of development of livestock farming in Uzbekistan and the EAEU countries
Authors: Abidov Abdujabbar , Mahmudov Nasir , Jaxongirov Ilimdorjon
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Innovative approaches to the feasibility study of options for calculation schemes of water supply
Authors: Khujaev Parviz , Bokiev Boki , Kholmurotov Turobqul , Murodov Parviz , Yakubov Alijon , Said Мajidzoda Tohir
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Building the inflower and realizing seed productivity of A.giganteum regel
Authors: Uralov Abdumannon , Mustafakulov Mukhammadjon , Mamatkulova Iroda , Sattorova Madina
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Changes in certain productivity indicators under the influence of water deficiency and drought of secale cereale I. Varieties
Authors: Makhramova M. Sh. , Urokov S. Kh.
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Development of metrological support for measurement of physico-chemical quantities
Authors: Axmedov Gayrat , Masharipov Shodlik
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Film tourism as an innovative direction of world and Ukrainian tourism development
Authors: Dodilova Kateryna , Poluda Viktoriya , Zhuchenko Valentyna
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: The usage of somatisms in English and Uzbek proverbs
Authors: Gadoeva Mavlyuda
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: The effect of using innovative technologies on the formation and development of competences of primary class students
Authors: Khayitov Umidjon , Qo’ldoshev Rustambek , Nurulloyev Firuz , Xalikova Umida
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: Pedagogical approach in forming the student’s personality and its leading importance in acquiring a profession
Authors: Zaripova Gulbahor
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001
RETRACTED: The role and practical significance of interesting issues in the development of students’ cognitive competencies
Authors: Turaev Khumoyiddin , Yadgarov Nadir , Mamatov Dilshod
Published: June 2024

See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf/202453800001