bluuebunny/crossref_metadata_2025 huggingface dataset:
Fast radio bursts in the discs of active galactic nuclei
Authors: Zhao Z Y , Chen K , Wang F Y , Dai Zi-Gao
Published: April 2024

Fast radio bursts (FRBs) are luminous millisecond-duration radio pulses with extragalactic origin, which were discovered more than a decade ago. Despite the numerous samples, the physical origin of FRBs remains poorly understood. FRBs have been thought to originate from young magnetars or accreting compact objects (COs). Massive stars or COs are predicted to be embedded in the accretion discs of active galactic nuclei (AGNs). The dense disc absorbs FRBs severely, making them difficult to observe. However, progenitors’ ejecta or outflow feedback from the accreting COs interact with the disc material to form a cavity. The existence of the cavity can reduce the absorption by the dense disc materials, making FRBs escape. Here, we investigate the production and propagation of FRBs in AGN discs and find that the AGN environments lead to the following unique observational properties, which can be verified in future observation. First, the dense material in the disc can cause large dispersion measure (DM) and rotation measure (RM). Secondly, the toroidal magnetic field in the AGN disc can cause Faraday conversion. Thirdly, during the shock breakout, DM and RM show non-power-law evolution patterns over time. Fourthly, for accreting-powered models, higher accretion rates lead to more bright bursts in AGN discs, accounting for up to 1 per cent of total bright repeating FRBs.
Gut-derived trimethylamine N-oxide promotes CCR2-mediated macrophage infiltration in acute kidney injury
Authors: Ren Yuan , Wang Zuoyuan , You Li , Zhou Jie , Huang Haowen , Chang Sansi , Wu Yuanhao , Xue Jun
Published: April 2024

Background

Inflammation is crucial in the development of acute kidney injury (AKI) and subsequent chronic kidney disease (CKD) following renal ischaemia–reperfusion (IR) injury. Gut microbiota metabolites trigger inflammation and affect IR-induced renal damage. Yet the driving factors and mechanisms are unclear. Trimethylamine N-oxide (TMAO), a gut-derived choline metabolite, is a strong pro-inflammatory factor that increases in patients with AKI and CKD. We hypothesized that TMAO can promote renal injury caused by IR.

Methods

Mice subjected to unilateral renal IR to induce AKI and CKD were fed a high-choline diet to observe the effects of TMAO on kidney inflammation, fibrosis and macrophage dynamics.

Results

A choline-rich diet altered the gut microbiota and elevated TMAO levels, exacerbating IR-induced AKI and subsequent CKD. Single-cell analysis identified a distinct subset of CCR2+ macrophages derived from monocytes as key responders to TMAO, intensifying immune cell interactions and worsening renal injury. TMAO promoted sustained CCR2 expression after IR, increasing macrophage infiltration. CCR2 deletion and antagonist RS-102895 improved TMAO-induced inflammation and fibrosis and alleviated renal injury induced by IR.

Conclusions

Our study provides valuable insights into the link between TMAO and IR-induced renal inflammation and fibrosis, emphasizing the critical role of TMAO-mediated macrophage infiltration via CCR2 as a key therapeutic target in the acute and chronic phases after IR.
Radical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma
Authors: Massaad Elie , Smith William J , Bradley Joseph , Esposito Eric , Gupta Mihir , Burns Evan , Burns Ryan , Velarde José K , Berglar Inka K , Gupta Rajiv , Martinez-Lage Maria , Dietrich Jorg , Lennerz Jochen K , Dunn Gavin P , Jones Pamela S , Choi Bryan D , Kim Albert E , Frosch Matthew , Barker Fred G , Curry William T , Carter Bob S , Nahed Brian V , Cahill Daniel P , Shankar Ganesh M
Published: April 2024

Background

Survival is variable in patients with glioblastoma IDH wild-type (GBM), even after comparable surgical resection of radiographically detectable disease, highlighting the limitations of radiographic assessment of infiltrative tumor anatomy. The majority of postsurgical progressive events are failures within 2 cm of the resection margin, motivating supramaximal resection strategies to improve local control. However, which patients benefit from such radical resections remains unknown.

Methods

We developed a predictive model to identify which IDH wild-type GBMs are amenable to radiographic gross-total resection (GTR). We then investigated whether GBM survival heterogeneity following GTR is correlated with microscopic tumor burden by analyzing tumor cell content at the surgical margin with a rapid qPCR-based method for detection of TERT promoter mutation.

Results

Our predictive model for achievable GTR, developed on retrospective radiographic and molecular data of GBM patients undergoing resection, had an area under the curve of 0.83, sensitivity of 62%, and specificity of 90%. Prospective analysis of this model in 44 patients found that 89% of patients were correctly predicted to achieve a residual volume (RV) < 4.9cc. Of the 44 prospective patients undergoing rapid qPCR TERT promoter mutation analysis at the surgical margin, 7 had undetectable TERT mutation, of which 5 also had a GTR (RV < 1cc). In these 5 patients at 30 months follow-up, 75% showed no progression, compared to 0% in the group with TERT mutations detected at the surgical margin (P = .02).

Conclusions

These findings identify a subset of patients with GBM that may derive local control benefits from radical resection to undetectable molecular margins.
Mycotoxins and bone growth: a review of the literature on associations between xenobiotic exposure and bone growth and development
Authors: Mehta Rukshan , Wenndt Anthony J
Published: April 2024

Mycotoxins are secondary metabolites of fungi that are known to be associated with linear growth faltering because of their impact on inflammation, intestinal damage, inhibition of protein synthesis, and micronutrient absorption. In this narrative review, we aim to extend this analysis to further explore associations between mycotoxins (aflatoxins, ochratoxins, trichothecenes including deoxynivalenol, T-2 toxin, and fumonisins) and long-bone growth, particularly during the saltatory periods of development. Linear growth is a direct function of skeletal development and long-bone growth. We therefore explored biological pathways and mechanisms of impact of these toxins in both animal and human studies, in addition to the epidemiology literature (post-2020). Given what is known of the effects of individual and combinations of mycotoxins based on the animal literature, we have identified a need for further research and examination of how these toxins and exposures may be studied in humans to elucidate the downstream impact on bone-related biomarkers and anthropometric indices used to identify and predict stunting in population-based studies.
Recent Advances in the Crosstalk between Brassinosteroids and Environmental Stimuli
Authors: Zhao Yuqing , Han Qing , Zhang Dawei
Published: April 2024

Due to their sessile lifestyle, plants need to optimize their growth in order to adapt to ever-changing environments. Plants receive stimuli from the environment and convert them into cellular responses. Brassinosteroids (BRs), as growth-promoting steroid hormones, play a significant role in the tradeoff between growth and environmental responses. Here, we provide a comprehensive summary for understanding the crosstalk between BR and various environmental stresses, including water availability, temperature fluctuations, salinization, nutrient deficiencies and diseases. We also highlight the bottlenecks that need to be addressed in future studies. Ultimately, we suppose to improve plant environmental adaptability and crop yield by excavating natural BR mutants or modifying BR signaling and its targets.
The 2024 Taiwanese Presidential Election on social media: Identity, policy, and affective virality
Authors: Chang Ho-Chun Herbert , Fang Yu Sunny
Published: April 2024

The 2024 Taiwanese Presidential Election is not just a critical geopolitical event, it also engages with themes of alternative candidacy, foreign policy, and affective polarization. At one point, a four-candidate race had emerged in a traditionally bipartisan election, with alternative candidates disrupting the dichotomy of Chinese vs. Taiwanese identity. Leveraging 911,510 posts and 101,600,047 engagements on social media, we analyze user discourse and engagement. First, we find traditional candidates derive more engagement on foreign policy and geopolitical issues, alternative candidates on domestic issues. Additionally, virality is generated by affective reasons, although in-group references generate more engagement than out-group references. Lastly, a puzzle is revealed where alternative candidates draw more homogeneous attention from national identity groups. Results suggest alternative candidacy can be generated by both positive and negative comparisons rooted in national identity.
Leveraging video evidence in domestic violence misdemeanour cases: Examination of case dispositions and case length
Authors: Backes Bethany L , Masters Mackenzie , Roman Krystle , Wasim Anna , Wood Leila
Published: April 2024

Law enforcement has used video recording devices (e.g. dash camera, body-worn camera) for more than 40 years, with body-worn cameras emerging in 2005 as a policing tool. However, little is known regarding how video evidence is leveraged in case decision-making and outcomes for domestic violence. Law enforcement may use cameras to enhance evidence collection in domestic violence cases, take statements from victims, witnesses, and offenders, record injuries and damages, and document the administration of risk/injury assessments. Preliminary research has indicated video evidence may have strong evidentiary value in domestic violence cases, however, has rarely controlled for other contributing factors. This study furthers our knowledge by examining how video evidence taken by law enforcement impacts case outcomes and length of time to disposition in a sample of closed, misdemeanour domestic violence cases within a large county in a southwestern state. A random sample of cases (n = 612) with and without video evidence were examined for differences in case disposition and case length. Additional evidentiary factors and case characteristics are considered such as prior criminal charges, victim–offender relationship, presence of non-video evidence, presence of witnesses, and gender of offender. Analyses indicate significant differences, such that cases with video evidence are associated with increased guilty pleas, increased convictions, and less time to closure/final case disposition. Findings have implications for the use of video evidence in strengthening the criminal justice response to domestic violence incidents in combination with other case factors.
Higher-degree Artin conjecture
Authors: Järviniemi Olli
Published: April 2024

For an algebraic number α we consider the orders of the reductions of α in finite fields. In the case where α is an integer, it is known by the work on Artin’s primitive root conjecture that the order is ‘almost always almost maximal’ assuming the Generalized Riemann Hypothesis (GRH), but unconditional results remain modest. We consider higher-degree variants under GRH. First, we modify an argument of Roskam to settle the case where α and the reduction have degree two. Second, we give a positive lower density result when α is of degree three and the reduction is of degree two. Third, we give higher-rank results in situations where the reductions are of degree two, three, four or six. As an application we give an almost equidistribution result for linear recurrences modulo primes. Finally, we present a general result conditional to GRH and a hypothesis on smooth values of polynomials at prime arguments.
HKT Manifolds: Hodge Theory, Formality and Balanced Metrics
Authors: Gentili Giovanni , Tardini Nicoletta
Published: April 2024

Let $(M,I,J,K,\Omega)$ be a compact HKT manifold, and let us denote with $\partial$ the conjugate Dolbeault operator with respect to I, $\partial_J:=J^{-1}\overline\partial J$, $\partial^\Lambda:=[\partial,\Lambda]$, where Λ is the adjoint of $L:=\Omega\wedge-$. Under suitable assumptions, we study Hodge theory for the complexes $(A^{\bullet,0},\partial,\partial_J)$ and $(A^{\bullet,0},\partial,\partial^\Lambda)$ showing a similar behavior to Kähler manifolds. In particular, several relations among the Laplacians, the spaces of harmonic forms and the associated cohomology groups, together with Hard Lefschetz properties, are proved. Moreover, we show that for a compact HKT $\mathrm{SL}(n,\mathbb{H})$-manifold, the differential graded algebra $(A^{\bullet,0},\partial)$ is formal and this will lead to an obstruction for the existence of an HKT $\mathrm{SL}(n,\mathbb{H})$ structure $(I,J,K,\Omega)$ on a compact complex manifold (M, I). Finally, balanced HKT structures on solvmanifolds are studied.
Patients with NPSLE experience poorer HRQoL and more fatigue than SLE patients with no neuropsychiatric involvement, irrespective of neuropsychiatric activity
Authors: Nikolopoulos Dionysis , Cetrez Nursen , Lindblom Julius , Palazzo Leonardo , Enman Yvonne , Parodis Ioannis
Published: April 2024

Objectives

Substantial proportions of patients with SLE report poor health-related quality of life (HRQoL). Our objective was to investigate the impact of neuropsychiatric involvement (NP) in SLE on patient-reported outcomes.

Methods

We analysed data from four phase III trials (BLISS-52, BLISS-76, BLISS-SC, EMBRACE; N = 2968). The NPSLE group comprised individuals with NP-BILAG A/B/C/D or score in any descriptor of the NP-SLEDAI-2K at baseline (N = 350), while the non-NPSLE group consisted of patients with NP-BILAG E (N = 2618). HRQoL was assessed with the SF-36, EQ-5D-3L, and FACIT-F. Full health state (FHS) was defined as ‘no problems’ in all EQ-5D dimensions.

Results

NPSLE patients reported lower scores in the SF-36 physical and mental component summary compared with the non-NPSLE population [mean (s.d.): 35.7 (9.1) vs 39.6 (9.6); P < 0.001 and 37.3 (12.1) vs 41.4 (11.0); P < 0.001, respectively]. NPSLE patients also exhibited impaired HRQoL in all EQ-5D dimensions compared with non-NPSLE patients (P < 0.05 for all). A substantially lower proportion of NPSLE patients experienced FHS in comparison with the non-NPSLE group (3.3% vs 14.5%; P < 0.001). NPSLE was associated with severe fatigue [23.8 (12.2) vs 31.5 (11.6); P < 0.001]. Notably, our findings revealed no discernible distinctions between active and inactive NPSLE patients with regard to SF-36, EQ-5D, FHS or FACIT-F scores.

Conclusion

NP in patients with SLE has a detrimental effect on HRQoL experience and is associated with severe fatigue, regardless of the degree of neuropsychiatric disease activity. Early intervention is warranted in NPSLE patients to enhance long-term HRQoL experience.
Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum
Authors: Thalhammer Melissa , Schulz Julia , Scheulen Felicitas , Oubaggi Mohamed El Mehdi , Kirschner Matthias , Kaiser Stefan , Schmidt André , Borgwardt Stefan , Avram Mihai , Brandl Felix , Sorg Christian
Published: April 2024

Background and Hypothesis

Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct pattern of aberrant thalamic nuclei volume across the spectrum and examined its potential associations with cognitive symptoms.

Study Design

We performed a FreeSurfer-based volumetry of T1-weighted brain MRIs from 137 healthy controls, 66 at-risk mental state (ARMS) subjects, 89 first-episode psychosis (FEP) individuals, and 126 patients with schizophrenia to estimate thalamic nuclei volumes of six nuclei groups (anterior, lateral, ventral, intralaminar, medial, and pulvinar). We used linear regression models, controlling for sex, age, and estimated total intracranial volume, both to compare thalamic nuclei volumes across groups and to investigate their associations with positive, negative, and cognitive symptoms.

Study Results

We observed significant volume alterations in medial and lateral thalamic nuclei. Medial nuclei displayed consistently reduced volumes across the spectrum compared to controls, while lower lateral nuclei volumes were only observed in schizophrenia. Whereas positive and negative symptoms were not associated with reduced nuclei volumes across all groups, higher cognitive scores were linked to lower volumes of medial nuclei in ARMS. In FEP, cognition was not linked to nuclei volumes. In schizophrenia, lower cognitive performance was associated with lower medial volumes.

Conclusions

Results demonstrate distinct thalamic nuclei volume reductions across the schizophrenia spectrum, with lower medial nuclei volumes linked to cognitive deficits in ARMS and schizophrenia. Data suggest a distinctive trajectory of thalamic nuclei abnormalities along the course of schizophrenia.
The standard form under pressure? On the ecological reconfiguration of product presentation using the example of consumables
Authors: Gajewski Eltje , Schrör Simon
Published: April 2024

This article provides a framework for analyzing valorizations and justifications for ecologically sustainable everyday products. By drawing on theoretical arguments from the French neo pragmatist approach of economics of conventions, especially the idea of enrichment, we develop a typology of valorizations that distinguishes between analytic and narrative presentations. A qualitative empirical analysis of green alternatives to standard consumables, such as coffee, textiles or hygiene products, is used to help explain the strategies by which sustainable products are placed and marketed. We state that sustainable product presentations use a range of established forms of valorization that also affects the justification of their often-higher prices. We conclude that the standard form of consumables comes under pressure while capitalist actors appear to incorporate the growing ecologic critique with a set of ecologic enrichments.
Museum Skins Enable Identification of Introgression Associated with Cytonuclear Discordance
Authors: Potter Sally , Moritz Craig , Piggott Maxine P , Bragg Jason G , Afonso Silva Ana C , Bi Ke , McDonald-Spicer Christiana , Turakulov Rustamzhon , Eldridge Mark D B
Published: April 2024

Increased sampling of genomes and populations across closely related species has revealed that levels of genetic exchange during and after speciation are higher than previously thought. One obvious manifestation of such exchange is strong cytonuclear discordance, where the divergence in mitochondrial DNA (mtDNA) differs from that for nuclear genes more (or less) than expected from differences between mtDNA and nuclear DNA (nDNA) in population size and mutation rate. Given genome-scale data sets and coalescent modeling, we can now confidently identify cases of strong discordance and test specifically for historical or recent introgression as the cause. Using population sampling, combining exon capture data from historical museum specimens and recently collected tissues we showcase how genomic tools can resolve complex evolutionary histories in the brachyotis group of rock-wallabies (Petrogale). In particular, applying population and phylogenomic approaches we can assess the role of demographic processes in driving complex evolutionary patterns and assess a role of ancient introgression and hybridization. We find that described species are well supported as monophyletic taxa for nDNA genes, but not for mtDNA, with cytonuclear discordance involving at least 4 operational taxonomic units across 4 species which diverged 183–278 kya. ABC modeling of nDNA gene trees supports introgression during or after speciation for some taxon pairs with cytonuclear discordance. Given substantial differences in body size between the species involved, this evidence for gene flow is surprising. Heterogenous patterns of introgression were identified but do not appear to be associated with chromosome differences between species. These and previous results suggest that dynamic past climates across the monsoonal tropics could have promoted reticulation among related species.
Evaluation of ATP bioluminescence for rapid determination of cleanliness of livestock trailers after a commercial wash
Authors: Letsch Flavia G , Welch Michael W , Meyer Matthew , Hedblom Grant A , Parr Eric , Classen Dyneah M , Dillard Molly , Boler Dustin D
Published: April 2024

Pathogens such as porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome (PRRSV), and E. coli are known to spread by contaminated vehicles and equipment. Pork producers have adopted trailer wash policies where each trailer is washed, disinfected, and dried before it can return to a farm. Cleanliness of livestock trailers after washing is determined by visual inspection rather than any objective method. Adenosine triphosphate (ATP) bioluminescence is used in many industries to provide real-time feedback on surface cleanliness through the detection of ATP from organic sources. That same technology may provide trailer wash facilities a way of objectively characterizing a livestock trailer’s suitability to return to a farm after washing. Two ATP luminometers (3M Clean-Trace and Neogen AccuPoint) were used to estimate the correlation between ATP bioluminescence readings and aerobic bacterial plate counts (APCs) from sampled surfaces and to determine locations within a livestock trailer that can accurately estimate surface cleanliness. Five locations in livestock trailers were evaluated. Those locations included the nose access door (NAD), back door flush gate, rear side access door (RSAD), belly flush gate (BFG), and belly side access door (BSAD). There was a positive log–log association between the two luminometers (r = 0.59, P < 0.01). Every log unit increase in one unit, resulted in a 0.42 log increase (P < 0.01) in the other unit. ATP can come from bacteria, yeasts, molds, and manure. There was a poor association (r ≥ 0.10, P ≥ 0.02) between APCs and the ATP luminometers. Still, an increase in relative light units (RLUs) resulted in a corresponding increase in colony-forming units. The greatest area of surface contamination measured by APC was the NAD. RLUs were also greater in the NAD compared to the RSAD, the BFG, and the BSAD (P ≤ 0.01). Because APCs and luminometer RLUs provided similar outcomes, statistical process control charts were developed to determine control limits for RLUs. This provides real-time feedback to trailer wash workers in determining cleanliness outcomes for livestock trailers. These data suggest that ATP bioluminescence can be a reliable method to monitor cleaning effectiveness in livestock trailers. Bioluminescence is a monitoring tool that should be used in conjunction with microbial methods to monitor procedures for cleaning and disinfection.
Free Trade and Subnational Development: Economic Activity and Human Welfare
Authors: Cruzatti C John
Published: April 2024

This paper delves into the subnational relationship between free trade agreements (FTAs) and human development worldwide. Utilizing a difference-in-differences and an event-study approach with high-spatial-resolution land-cover data and a comprehensive time series of national-level FTA indicators for 207 countries, the study quantifies the effects of FTAs on subnational development. The findings indicate a small negative impact of FTAs on the Human Development Index but a notable positive impact on economic activity, with urbanized regions benefiting the most. Unequal and more vulnerable regions grapple with declining human development indicators. The depth of FTAs does not sway these outcomes. These patterns raise questions about the inclusivity and equitable distribution of the benefits of trade liberalization. While prior literature has examined the national implications of FTAs, this paper provides insight into the subnational repercussions of FTAs and emphasizes the role of inequality in hindering holistic developmental benefits from FTAs.
A Systematic Review of Psycho-Spiritual Interventions in the NICU
Authors: Brelsford Gina M. , Doheny Kim K. , Stoner Jennifer
Published: April 2024

Background:

The presence of psychospiritual supports and interventions for neonatal intensive care unit (NICU) parents is unclear.

Purpose:

This systematic review examines the psychological and medical literature for psychospiritual interventions designed to support parents’ mental health and psychological well-being during or after the NICU experience.

Data Sources:

Data sources include PubMed, PsycINFO, and Cochrane Library (Cochrane Database of Systemic Reviews, Cochrane Central Register of Controlled Trials) with peer-reviewed studies published between 2013 and 2023.

Study Selection:

Peer-reviewed studies that included spiritual and psychological intervention components focused on supporting parents during or after the NICU were included for this systematic review. There were 42 records located in 3 databases ultimately yielding 4 peer-reviewed studies that met inclusion criteria. Articles must have been written in English and evaluate parents’/caregivers’ mental health/psychological well-being in relation to a psychospiritual intervention.

Data Extraction:

Because of the small number of studies, article summaries are provided within the results section and were written by the first author with approval by the second and third authors.

Results:

Results indicated that when psychological (focus on coping) and spiritual components were included psychological and well-being outcomes were better for NICU parents.

Implications for Practice and Research:

The inclusion of psychological and spiritual aspects of coping and supportive care is necessary for the best family-centered NICU care. More work needs to be done to develop psychospiritual supports and include fathers in these endeavors as most work occurs with mothers. Nurses need support and training to facilitate family-centered care with a focus on parents’ psychospiritual needs.
Management of Humeral Shaft Fracture: A Network Metanalysis of Individual Treatment Modalities
Authors: Colasanti Christopher A. , Anil Utkarsh , Cerasani Michele N. , Li Zachary I. , Morgan Allison M. , Simovitch Ryan W. , Leucht Philipp , Zuckerman Joseph D.
Published: April 2024

Objective:

The purpose of this study was to perform a network meta-analysis (NMA) of level I and II evidence comparing different management techniques to define the optimum treatment method for humeral shaft fractures (HSF).

Methods:

Data Sources: A systematic review of the literature using PRISMA guidelines of MEDLINE, EMBASE, and Cochrane Library was screened from 2010-2023.

Study Selection:

Inclusion criteria were evidence level I or II studies comparing nonoperative and/or operative repair techniques including open reduction internal fixation plate osteosynthesis (ORIF-Plate), minimally invasive percutaneous plating (MIPO), and intramedullary nail fixation (IMN) for the management of HSF (AO OTA 12A,B,C).

Data Extraction:

The risk of bias (ROB) and methodologic quality of evidence (MQOE) were assessed according to the guidelines designed by the Cochrane Statistical Methods Group and Cochrane Methods Bias Group.

Data Synthesis:

NMA were conducted with a frequentist approach with a random effects model using the netmeta package version 0.9-6 in R.

Results:

A total of 25 studies (1,908 patients) were included. MIPO resulted in the lowest complication rate (2.1%) when compared to ORIF-Plate (16.1%) (OR, 0.13;95%CI,0.04-0.49). MIPO resulted in the lowest nonunion rate (0.65%) compared to all management techniques (OR 0.28; 95%CI, 0.08-0.98), whereas Non-Op resulted in the highest (15.87%) (OR,3.48; 95%CI, 1.98-6.11). MIPO demonstrated the lowest rate of postoperative radial nerve palsy overall (2.2%) and demonstrated a significantly lower rate compared to ORIF-Plate (OR,0.22,95% CI, 0.07-0.71, p=0.02). IMN resulted in the lowest rate of deep infection (1.1%) when compared to ORIF-Plate (8.6%; p=0.013). MIPO resulted in a significantly lower DASH score (3.86±5.2) and higher ASES score (98.2± 1.4) than ORIF-Plate (19.5±9.0 & 60.0±5.4, p<0.05).

Conclusion:

The results from this study support that surgical management results in better postoperative functional outcomes, leads to higher union rates, reduces fracture healing time, reduces revision rate and decreases malunion rates in patients with HSFs. Additionally, MIPO resulted in statistically higher union rates, lowest complication rate, lowest rate of postoperative radial nerve palsy, and lower intraoperative time, while resulting in better postoperative DASH and ASES scores when compared to nonoperative and operative (ORIF & IMN) treatment modalities.

Level of Evidence:

Level II. See Instructions for Authors for a complete description of levels of evidence.
Mobility Is Medicine, Too: Creating a Culture of Mobility Amongst Hospitalized Patients With Cancer to Improve Patient Outcomes
Authors: Morjaria Sejal , Carmody Claire , Navlakha Saket , Zhou Wei , Braccia Donna , Aquino Jennifer , Roumm Adam , Martin Steve , Syrkin Grigory
Published: April 2024

Background:

Despite decades of evidence demonstrating the effectiveness of multidisciplinary mobility initiatives in improving patient clinical outcomes, the impact of mobility programs in oncology-specific settings has been ignored.

Objective:

The objective of this initiative is to test evidence-based mobility interventions in a cancer care center to create a culture among clinicians that prioritizes patient mobilization.

Methods:

We compared postintervention and preintervention outcomes using logistic regression analysis and time-to-event modeling to assess hospital length of stay. Basic statistical methods assessed whether improving mobility influenced clinical outcomes and clinician culture.

Results:

Outcome data from 493 in the postintervention arm were compared to 498 patients in the preintervention arm. Patients in the postintervention group had 39% decreased odds of having the rapid response team called (confidence interval [CI] =0.39–0.97; P = .03) and 46% decreased odds of being admitted to the intensive care unit (CI = 0.29–1.02; P = .05) compared to the preintervention group. No safety issues were associated with these interventions.

Conclusions:

Hospitalized patients with cancer are especially prone to considerable debility due to their disease and treatment effects. Our initiative to create a mobility protocol in 1 medical unit resulted in positive clinical outcomes.

Implications for Practice:

Findings from this study can be used to increase recognition of the benefits of mobility programs for hospitalized cancer patients.

What is Foundational:

Promoting mobility in the hospital often involves collaboration among various healthcare professionals, including nurses, physical therapists, occupational therapists, and physicians. This interdisciplinary approach ensures that patients receive holistic care tailored to their specific needs.
Definitions for Hypertensive Response to Exercise
Authors: Ghidoni Céline , Kruzik Matthias , Rossi Valentina A. , Caselli Stefano , Schmied Christian M. , Niederseer David
Published: April 2024

Broad evidence indicates that hypertensive response to exercise (HRE) is associated with future hypertension (aHT) at rest and cardiovascular morbidity and mortality. Nevertheless, a consensus on the definition of HRE is lacking and the comparability of the available data is difficult due to a wide variation of definitions used. This review aims to harmonize currently available definitions of HRE in normotensive and athletic populations and to propose a generally valid cut-off applicable in everyday clinical practice. A literature search on PubMed and Embase was conducted to assemble and analyze the most recent data. Various definitions of HRE were identified and linked with future cardiovascular diseases. Forty-one studies defined HRE at a peak systolic blood pressure (SBP) above or equal to 200 mmHg in men and 25 studies for 190 mmHg in women. Peak diastolic blood pressure (DBP) between 90 and 110 mmHg was reported in 14 studies, relative DBP increase in four. Eight studies defined HRE as SBP between 160 and 200 mmHg at 100 watts. 17 studies performed submaximal exercise testing, while two more looked at BP during recovery. A plethora of other definitions was identified. In athletes, total workload and average blood pressure during exercise were considerably higher. Based on the presented data, the most commonly used definition of HRE at peak exercise is 210/105 mmHg for men, 190/105 mmHg for women, and 220/210 mmHg for athletes. Furthermore, a uniform exercise testing protocol, a position statement by leading experts to unify the definition of HRE, and prospective studies are warranted to confirm these cut-offs and the associated morbidity and mortality.
Retinal Vascular Imaging Application in Women’s Reproductive Health: Clinical Implications and Future Directions
Authors: Lim Beth Shi Yu , Li Ling-Jun
Published: April 2024

Over the past two decades, population-based studies employing semiautomatic computer-assisted programs have uncovered associations between retinal microvascular features and various systemic conditions. As the recognition of retinal imaging in cardiometabolic health grows, there is increasing evidence supporting its application in women’s health, particularly during the reproductive age. This review aims to summarize the indications of retinal imaging in women’s health and intergenerational health, where suboptimal retinal imaging has been found to mirror pathological systemic changes, such as suboptimal hemodynamic circulation, inflammation, endothelial dysfunction, oxidative stress, and hypoxia in vivo. Findings from Singapore Growing Up in Singapore Towards Healthy Outcomes and Singapore Preconception Study of Long-Term Maternal and Child Outcomes cohorts have reported serial changes in retinal conventional microvascular features (e.g., retinal arteriolar narrowing, retinal venular widening) and retinal geometric microvascular features (e.g., sparse fractal dimension, enlarged branching angle, and increased curvature tortuosity) during the preconception and antenatal phases. These morphological abnormalities were found to be related to female fertility, maternal antenatal health conditions, postnatal maternal cardiometabolic health, and intergenerational health in the fetus. Given the compelling evidence of the ability to detect microvascular changes through noninvasive methods at an early stage, retinal imaging holds the potential to facilitate timely interventions, mitigate the progression of complications, and prevent adverse pregnancy outcomes. Looking ahead, the convergence of artificial intelligence and advanced imaging techniques heralds a promising era in women’s health research and clinical practice.
Pilot Test of A Gender-conscious Sexual Health Intake Questionnaire: Increasing Inclusivity and Mitigating Bias in Sexual History Taking
Authors: Zhang Tenny R. , Castle Elijah , Dubach-Reinhold Charlie , Blasdel Gaines , Kloer Carmen , Alford Ashley , Bluebond-Langner Rachel , Zhao Lee C.
Published: April 2024

Background:

Sexual health is critical to overall health, yet sexual history taking is challenging. LGBTQ+ patients face additional barriers due to cis/heteronormativity from the medical system. We aimed to develop and pilot test a novel sexual history questionnaire called the Sexual Health Intake (SHI) form for patients of diverse genders and sexualities.

Methods:

The SHI comprises four pictogram-based questions about sexual contact at the mouth, anus, vaginal canal, and penis. We enrolled 100 sexually active, English-speaking adults from a gender-affirming surgery clinic and urology clinic from November 2022 to April 2023. All surveys were completed in the office. Patients also answered five feedback questions and 15 questions from the Patient-Reported Outcomes Measurement Information System Sexual Function and Satisfaction (PROMIS-SexFS) survey as a validated comparator.

Results:

One hundred patients aged 19–86 years representing an array of racial/ethnic groups, gender identities, and sexuality completed the study. Forms of sexual contact varied widely and included all possible combinations asked by the SHI. Feedback questions were answered favorably in domains of clinical utility, inclusiveness of identity and anatomy, and comprehensiveness of forms of sexual behavior. The SHI captured more positive responses than PROMIS-SexFS in corresponding questions about specific types of sexual activity. The SHI also asks about forms of sexual contact that are not addressed by PROMIS-SexFS, such as penis-to-clitoris.

Conclusions:

SHI is an inclusive, patient-directed tool to aid sexual history taking without cisnormative or heteronormative biases. The form was well received by a diverse group of participants and can be considered for use in the clinical setting.
Self-induced Hot Water Finger Burn Trying to Get Feeling Back after Ropivacaine Block
Authors: Rohde Rachel S. , Wong Alison , Lalonde Donald H.
Published: April 2024

This case report is about a patient with self-induced hot water burns several hours after an infraclavicular block with ropivacaine for a scaphoid fracture operation. This patient was honest about what happened. However, some patients are too embarrassed to admit what they did to themselves. The injury may be misdiagnosed by the emergency department physician or by the surgeon because the history is incomplete. The resulting burn, which can lead to fingertip loss when severe, can be erroneously misdiagnosed as an ischemic injury after lidocaine with epinephrine local anesthesia. Most hand surgeons have seen ischemic finger injuries the morning after failed finger replantation. Acutely ischemic fingers from arterial insufficiency do not have parallel hot water burn lines, reactive hyperemia at the base of the burn, or burn blisters at the fingertips. The purpose of this article and its video is to help physicians and nurses recognize the three signs of self-induced hot water finger burns after local anesthesia: (1) a parallel hot water line in the fingers at the proximal burn level; (2) reactive hyperemia just proximal to the burn line; (3) burn blisters in the submerged fingertips. When seeing postoperative patients with these signs, the examining clinician may tactfully ask: “Did you try to get the feeling back in your fingers by warming them?” It is hoped that the patient may then reveal that he tried warming the finger in water, and that may lead to the truth that the water was indeed too hot.
Clinical study on treatment of cervical spondylotic radiculopathy (Qi stagnation and blood stasis syndrome) with Gao’s nape needle and Shentong Zhuyu decoction
Authors: Haishen Zhao , Manya Wang , Hong Ye , Kejun Shi , Ruiqian Guan
Published: April 2024

Background:

Cervical spondylotic radiculopathy is currently one of the common orthopedic diseases, mainly characterized by neck pain, stiffness, limited mobility, and related symptoms of nerve root compression, which seriously troubles people’s work and life.

Methods:

Ninety cases of cervical spondylotic radiculopathy (Qi stagnation and blood stasis syndrome) were randomly divided into treatment group and control group, 45 cases in each group. The control group was treated with western medicine (nerve nutrition, pain relief, and circulation improvement drugs), and the treatment group was treated with Gao’s nape needle combined with modified Shentong Zhuyu decoction on the basis of the control group. Before and after 2 weeks, TCM syndrome score, TCM curative effect, visual analogue scale score, numbness score, neck disability index score, related serum inflammatory factors (interleukin-10 [IL-10], interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α]), related hemorheological indexes (plasma viscosity, high shear whole blood viscosity, low shear whole blood viscosity level) were used as evaluation indexes to evaluate the effect.

Results:

After treatment, the total effective rate of the treatment group was 91.11%, which was better than that of the control group (78.78%), and the TCM syndrome scores of the 2 groups were decreased, the treatment group was better than that of the control group, and the differences were statistically significant (P < .05). After treatment, the visual analogue scale score, numbness score, and neck disability index score were decreased in both groups, and the decrease in the treatment group was more significant than that in the control group, and the differences were statistically significant (P < .05). After treatment, the related serum inflammatory factors (IL-10, IL-6, TNF-α) and related hemorheological indexes (plasma viscosity, high-shear whole blood viscosity, low-shear whole blood viscosity) were decreased in both groups, and the decrease in the treatment group was more significant than that in the control group, and the differences were statistically significant (P < .05).

Conclusion:

The treatment of cervical spondylotic radiculopathy (Qi stagnation and blood stasis syndrome) with Gao’s nape needle and modified Shentong Zhuyu decoction can improve the curative effect of traditional Chinese medicine, improve the related discomfort symptoms (neck tenderness, adverse activity, numbness, etc), improve the neck function, reduce IL-10, IL-6, TNF-α, and other related serum inflammatory factors, and improve hemorheological indicators.
Effect of continuity nursing based on the theory of Knowledge-Attitude-Practice on quality of life, self-efficacy, and treatment compliance in elderly patients with benign prostatic hyperplasia
Authors: Mao Jing , Wang Juan , Li Rong , Xiang Juan , Zhao Turong , Chen Lin , Li Gang
Published: April 2024

Objective:

The purpose of this study was to analyze the impact of continuity nursing based on the theory of Knowledge-Attitude-Practice (KAP) on the quality of life, self-efficacy, and treatment compliance in elderly patients with benign prostatic hyperplasia (BPH).

Methods:

In this single-center, randomized controlled study, a total of 232 elderly BPH patients who received treatment at our hospital from June 2020 to June 2022 were selected as the research subjects. They were randomly divided into the research group (n = 116) and the control group (n = 116). The control group received conventional interventions, while the research group received continuity nursing based on the theory of KAP on the basis of control group. Anxiety, depression, self-care agency, quality of life, self-efficacy, treatment compliance, and nursing satisfaction were compared between these 2 groups.

Results:

Before nursing intervention, both groups showed a decrease in SAS and SDS scores after the intervention. Furthermore, self-care ability, self-care responsibility, self-concept, health knowledge level, role function, emotional function, somatic function, cognitive function, social function, and General Self-Efficacy Scale scores increased. Additionally, the research group demonstrated lower/higher levels than the control group (P < .05). The research group exhibited higher treatment compliance (P = .002) and greater nursing satisfaction compared to the control group (P = .014).

Conclusion:

Continuity nursing based on the theory of KAP can improve negative emotions in elderly BPH patients, enhance their self-efficacy and treatment compliance, and achieve better clinical outcomes.
Exploring the mechanism of ShenGui capsule in treating heart failure based on network pharmacology and molecular docking: A review
Authors: Luo Xiang , Shi Yunke , Ma Yiming , Liu Yixi , Jing Pan , Cao Xingyu , Wang Jincheng , Hu Zhao , Cai Hongyan
Published: April 2024

ShenGui capsule (SGC), as a herbal compound, has significant effects on the treatment of heart failure (HF), but its mechanism of action is unclear. In this study, we aimed to explore the potential pharmacological targets and mechanisms of SGC in the treatment of HF using network pharmacology and molecular docking approaches. Potential active ingredients of SGC were obtained from the traditional Chinese medicine systems pharmacology database and analysis platform database and screened by pharmacokinetic parameters. Target genes of HF were identified by comparing the toxicogenomics database, GeneCards, and DisGeNET databases. Protein interaction networks and gene-disorder-target networks were constructed using Cytoscape for visual analysis. Gene ontology and Kyoto Encyclopedia of Genes and Genomes were also performed to identify protein functional annotations and potential target signaling pathways through the DAVID database. CB-DOCK was used for molecular docking to explore the role of IL-1β with SGC compounds. Sixteen active ingredients in SGC were screened from the traditional Chinese medicine systems pharmacology database and analysis platform, of which 36 target genes intersected with HF target genes. Protein-protein interactions suggested that each target gene was closely related, and interleukin-1β (IL-1β) was identified as Hub gene. The network pharmacology analysis suggested that these active ingredients were well correlated with HF. Kyoto Encyclopedia of Genes and Genomes enrichment analysis suggested that target genes were highly enriched in pathways such as inflammation. Molecular docking results showed that IL-1β binds tightly to SGC active components. This experiment provides an important research basis for the mechanism of action of SGC in the treatment of HF. In this study, the active compounds of SGC were found to bind IL-1β for the treatment of heart failure.
ALYREF m5C RNA methylation reader predicts bladder cancer prognosis by regulating the tumor immune microenvironment
Authors: Pan Wengu , Liu Xiaoli , Liu Shuangde
Published: April 2024

Background:

5-Methylcytidine (m5C) methylation is a recently emerging epigenetic modification that is closely related to tumor proliferation, occurrence, and metastasis. This study aimed to investigate the clinicopathological characteristics and prognostic value of m5C regulators in bladder cancer (BLCA), and their correlation with the tumor immune microenvironment.

Methods:

Thirteen m5C RNA methylation regulators were analyzed using RNA-sequencing and corresponding clinical information obtained from the TCGA database. The Cluster Profiler package was used to analyze the gene ontology function of potential targets and enriched the Kyoto Encyclopedia of Genes and Genomes pathway. Kaplan–Meier survival analysis was used to compare survival differences using the log-rank test and univariate Cox proportional hazards regression. The correlation between signature prognostic m5C regulators and various immune cells was analyzed. Univariate and multivariate Cox regression analyses identified independence of the ALYREF gene signature.

Results:

Nine out of the 13 m5C RNA methylation regulators were differentially expressed in BLCA and normal samples and were co-expressed. These 9 regulators were associated with clinicopathological tumor characteristics, particularly high or low tumor risk, pT or pTNM stage, and migration. Consensus clustering analysis divides the BLCA samples into 4 clusters. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment annotation and gene ontology function analysis identified 273 upregulated and 594 downregulated genes in BLCA. Notably, only ALYREF was significantly correlated with OS (P < .05). ALYREF exhibited significant infiltration levels in macrophage cells. Therefore, we constructed a nomogram for ALYREF as an independent prognostic factor. Additionally, we observed that both the mRNA and protein levels of ALYREF were upregulated, and immunofluorescence showed that ALYREF was mainly distributed in nuclear speckles. ALYREF overexpression was significantly associated with poor OS.

Conclusion:

Our findings demonstrated the potential of ALYREF to predict clinical prognostic risks in BLCA patients and regulate the tumor immune microenvironment. As such, ALYREF may serve as a novel prognostic indicator in BLCA patients.