bluuebunny/crossref_metadata_2025 huggingface dataset:
CHARACTERISTIC OF MYOCARDIAL INFARCTION IN DIABETIC PATIENTS
Authors: Sovtić S. , Trajković T. , Tomić S. , Perić V. , Jovanović A. , Novaković T. , Pajović S. , Marčetić Z.
Published: November 2024

The aim of our work was to inquire characteristics of myocardial infarction in diabetic patients.We questioned
prospectively 441 patients, diagnosed with acute myocardial infarction. Diabetes mellitus (DM) was found in 31,3%
patients. Atrial fibrillation was found in 16,7% patients with DM and 7,3% on patients without DM(p<0,05).Ventricular
arrhythmias gr.III was found in 18,8% patients with DM and 15,8% on patients without DM (p>0,05), gr. IV 24,6% vs.
12,9% (p<0,05) and gr.V 18,1% vs.9,9% (p<0,05). Heart failure (NYHA I) was found in 10,9% patients with DM and
10,6% on patients without DM (p>0,05), heart failure NYHA II 13,8 vs.10,6% (p>0,05), heart failure NYHA III 14,5% vs.
5,6% (p<0,05) and heart failure NYHAIV 10,1 vs. 3,3% (p<0,05).Cardiogenic shock was found in 21,7% patients with DM
and 10,2% on patients without DM (p<0,05). QRS scor was found 8,3+-2,9 in patients with DM and 4,5+-1,5 on patients
without DM (p<0,05). In-hospital mortality was found 20,3% in patients with DM and 8,2% on patients without DM
(p<0,05). Post-hospital mortality was found 10,2% in patients wuth DM and 5,1% on patients without DM (p>0,05).
Myocardial infarction in patients with DM have difficulty clinical flow and higher mortality
VITREOUS HAEMORRHAGIAE IN PENETRATING EYE INJURES IN CHILDREN
Authors: Mirković M. , Žorić L. , Jakšiċ V.
Published: November 2024

Penetrating injuries of the eye are an important cause of unilateral visual loss. Hemophthalmos is frequently and
serious complication in penetrating eye injuries. We studied a series of 422 cause, children aged 1-15 years, treated from
1989 through 1998. There were 324 (76.78%) boys and 98 (23.22%) girls in the study group, with a mean age of 8 years 4
monats. Complication from penetrating eye injuries with hemophthalmos is noticed in 62 cases (14.69%). 
EVALUATION OF USAGE MEDICAMENTS FOR TREATMENT OF GASTROINTESTINAL TRACT AND METABOLISM AND TREATMENT OF MUSCULAR AND SCELETAL SYSTEM DISEASES ON THE BASIS OF DEFINED DAILY DOSE
Authors: Vojnović M. , Jakovljević Đ. , Jakovljević V. , Stanulović M. , Pilija V.
Published: November 2024

Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the
dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. According to the obteined data, medicaments
used in treatment of gastroinestinal tract contributed with 15.52 DDD/1000 inhabitants per day. Most commonly used are antacids and anti-ulcer drugs (8.14 DDD/1000 inhabitants per day). Medicaments used in treatment of muscular and skeletal
system contributed with 14.30 DDD/1000 inhabitants per day. Antiinflammatory and antirheumatic drugs sre used in amounts of 14.18 DDD/1000 inhabitants per day. In our country there is no complex survey of drug usage because there is no way of monitor ing which could apprehend all possible information sources. Defined daily dose is not introduced into practical qualitative and quantitative monitoring. It is necessary to make systematic network of information sources to provide for insight into medicament usage
CONGENITAL HEART DISEASE - CASE REPPORT
Authors: Marčetić Z. , Sovtić S.
Published: November 2024

Most frequent congenital malformations in human are congenital heart disease (30%). In this article we represented basic of their etiology, pathogenesis, diagnostic and new therapeutics possibilities. Also we represented three cases of congenital heart disease. These cases we considered as very interesting. First of all, in this article we try to emphasize some aspects of this problem, which is not well known, especially in our environment. This very rare congenital heart disease shows how much diagnostic procedure can be difficult and treatment hard or impossible besides big improvement, which has be done last decades. We must learn much more about congenital heart disease!
RARE INJURY OF MALE GENITALS CAUSED BY ELEKTRICITY WITH LASTING INVALIDITY
Authors: Ivanović D. , Petronić D. , Stefanović G.
Published: November 2024

Injuries of genital organs caused by electricity are rarely isolated and they begin with injuries of the other parts of a body. We present you a patient with very rare and difficult genital organs injury which brought to a very severe damage and lasting invalidity. The genitals were being carbonized but a patient have to spend the rest of his life with a final perineostomy.
FEAR OF ADOLESCENTS ADOLESCENTS FROM STOMATOLOGICAL OLOGICAL INTERVENTIONS
Authors: Popović-Babić D. , Ivetić V. , Apostolović M. , Naumović N. , Biskupljanin B.
Published: November 2024

By this investigation an attempt has been done to explain the existence of fear in adolescents from stomatological treatment, by appraisal of fear through its two components (congenitive and physiological). Congenitive component of fear,
was followed by written questionnaire before the first stomatologic intervention (by the standard scale of general anxiety). In the investigation participated 100 adolescents. On the basis of analysis of the question mark the adolescents have been
placed into three groups: normal, pathological and increasingly anxious. During third visit (three stomatologic interventions) each patient was recived the placebo (vitamin C one half of the tablet, orally, 30 minutes before start of work of stomatology interventions which were identical, i.e. the sanitation of deep carries). Physiological component (sweating and voice) have been appraised by the method of clinical observation. All parameters were measured before all three stomatologic interventions. In this investigation, in parameters measured by clinical observation happened a diminution of strong small of sweating, trembling voice stammering in occasion of application of placebo therapy
CORRELATION BETWEEN COLPOSCOPICAL AND HISTOPATOLOGICAL FINDINGS AT CARCINOMA PVU
Authors: Cvetkoviċ S. , Petrović B. , Stanišić S. , Milinčić N. , Stanišić N.
Published: November 2024

Of 130 examined women who had not undergone a cytological and colposcopy check-up for at least a year, there were positive colposcopy: mosaic 39 (30,00 %), atipic vascularisation 15 (11,54 %) and suspect of invasive cervical cancer 1 (0,77 %). While the invasive carcinoma was ascertained most frequently at the ages of 40 to 59. The frequent incidence of severe displasia in subjects is 2,31 %, microinvasive cervical cancer 1,45 %, and the incidence of the invasive carcinoma is 3,85%.
MONITORING THE ADVERSE ADVERSE DRUG REACTIONS REACTIONS TODAY
Authors: Janićijević-Hudomal S. , Rašić J. , Mitić R. , Stanojević Z.
Published: November 2024

One the of most importante charactersistics of drug is a drug safety. However, there is no absolute safety. Medicines are troughly tested in controlled clinical trials with limiting population and short duration. Experience has shown that much of our knowledge about a medicine becomes available during the subsequent prescribing practice. Therefore there is a need for continued monitoring medicines after granting of product licence for a new drug (phrmacovigilance). WHO international system for drug safety monitoring as maintained by the Upsala Monitoring Centre (UMC) in Sweden, has built up vastedatabase of reports of suspect adverse drug reactions, coming from national centres in 75 countries in all of the world. The international system products valuable information from countries around the world, to support regulatory follow-up and decision-making. Emphasis is on those signals that may remain at the national level, because of small numbers or absence of local reports. The aim of the WHO's international pharmacovigilance program is a safe and rational medicines evrywhere. In Serbia as of 2005. National Medical Devices Agency is acting on behalf of the Ministry of Health as National Centre for Adverse Drug Reactions. The form for reporting adverse effects of medicines, in both pre-marketing and post-marketing phase can be found and downloaded in Word format on the Agency`s web site www.alims.sr.gov.yu.
DIABETIC NEPHROP IABETIC NEPHROPATHIA AND ACE INHIBIT ACE INHIBITORS
Authors: Novaković T. , Jovanović S. , Sovtić S. , Pajović S. , Stolić R.
Published: November 2024

Diabetes is the most common cause of end-stage renal disease .in United States , Europa and Japan. Approximately 40% of patients with type 1 diabetes and 5-15% of patients with type 2 diabetes eventually develop end-stage renal disease. Risk factors for development of diabetic nephropathy include hyperglycemia, hypertension, positive family history of nephropathy and hypertension, and smoking. Key elements in the primary care of diabetes include glycemic control, blood pressure control, and screening for microalbuminuria. In general, the goal for glycemic control is a blood glucose level as close to normal (HbA C <7%) . Blood pressure control is at least as important as glucose control, especially after the onset of 1 renal damage, and blood pressure should be consistently <130/85. Screening for diabetic nephropathy involves monitoring at least yearly for urinary albumin excretion >30 mg per day. Microalbuminuria is defined as the urinary excretion of 30300 mg of albumin per day. Both glycemic control and rigorous control of blood pressure have significant impact on prevention and progression of diabetic nephropathy. Identification of patients with microalbuminuria selects a population of patients with increased mortality. Microalbuminuria screening should begin at the time of diagnosis. ACE inhibitors should be used when microalbuminuria is present regardless of the presence or absence of hypertension in type 1 diabetes and are widely.
used in normotensive patients with type 2 diabetes, as well.The effect of ACE inhibitors is probably not only via lowered
systemic blood pressure but also via direct effects on intraglomerular hemodynamics. 
RECURENT ECURENT CHILDREN HEADACHES IN CHILDREN HEADACHES IN VOJVODINA
Authors: Knežević-Pogančev M. , Ivetić V.
Published: November 2024

Among the Vojvodinian children aged between 3-16, 27,69% have recurrent headaches, 18,83% have nonmigraine and 8,63% migraine headaches. Children aged between 3-7 suffer recurrent headaches in 18,64%, 14,77% nonmigraine and 3,87% migraine. The presence of migraine headaches rises proportionally to aging, more significantly than the presence of non-migraine ones from 2,65% to 11,72% with boys, and from 2,71% to 15,86% with girls. The presence of nonmigraine headaches with children aged 3-16, grows proportionally to age, from 14,0% to 21,15% for boys, and from 14,36% to 24,84% for girls. Migraine with aura makes 25,55%, migraine without aura 67,21% and other migraine headaches 7,23% of the migraine syndromes
DOXYCYCLIN IN INHIBITION OF METALLOPROTHEASIS IN GONARTHROSIS
Authors: Minić S.
Published: November 2024

Gonarthrosis is degenarative knee disease as well as the commonest chronic knee arthropaty. Nowadays more attention is given to modern pathogenesis of arthrosis in two levels: 1. immunological; 2. some ferments disbalance phenomenon. In the second level of pathogenesis, a special atention is given to metalloprotheasis. The importance of doxycyclin on the reduction of metalloprotheasis in synovia has a great therapy importance not only theoretically but pratically as well 78 patients with primary and secundary gonarthrosis has been examined (19 men and 59 women) the appliance of doxycyclin in clinic elements common for gonarthrosis caused the improvemnt of all clinic parameters especially muscular strenght and pain, but the largest improvement was noticed in knee - joint circumference
PROTECTION OF ORGANISM AGAINST REACTIVE OXYGEN SPECIES
Authors: Kisić Božović B. , Mirić D. , Dragojević M. , Dragojević I.
Published: November 2024

Cells continuously produce free radicals and reactive oxygen species as part of metabolic processes. These free radicals are neutralized by antioxidant defense system consisting of enzymes such as catalase, superoxide dismutase, glutathione peroxidase, and numerous non-enzymatic antioxidants, including vitamins A, E and C, glutathione, ubiquinone, and flavonoids. Antioxidants include both water and lipid soluble varieties. The lipid soluble antioxidants are located in the cellular membranes and lipoproteins, whereas the water soluble antioxidants are present in the aqueous environments, such as fluids inside cells and in the blood.
THE ENDOCRINE FUNCTION OF ADIPOSE TISSUE AND ITS CLINICAL SIGNIFICANCE
Authors: Leštarević S. , Anðelković Z.
Published: November 2024

Adipose tissue secretes bioactive peptides, termed 'adipokines', which act locally and distally through autocrine, paracrine and endocrine signals. Those signals influences the answers of other tissues and organs including hypothalamus, pancreas, liver, sceletal muscles, endotel an immune system. Increased production of most adipokines impacts on multiple functions such as appetite and energy balance, immunity, insulin sensitivity, angiogenesis, blood pressure, lipid metabolism and haemostasis, all of which are linked with cardiovascular disease. Leptin is a critical mediatorof energy balance that relays information regarding the depletion or accumulation of fat stores to the brain. Althoughmany of leptin's effects result rb from a direct action ofleptin on hypothalamic neurons, the functional leptin receptor(long-form or lep ) is also found on many tissues outside the central nervous system (CNS), including immune cells. Obese individuals seem to be resistantto the hypothalamic effects of leptin (maybe because of defective blood-brain barrier transport), the catabolic pathways designed to reduce appetite and increase energy expenditure are not activated and excess body weight is maintained). Adipokines like adiponectin and leptin, at least in physiological concentrations, are insulin sparing as they stimulate beta oxidation of fatty acids in skeletal muscle. The role of resistin is less understood. It is implicated in insulin resistance in rats, but probably not in humans. Adiponectin and resistin are adipocyte-derived polypeptide hormones playing a role in metabolic homeostasis. Their plasma levels are inversely (adiponectin) or directly (resistin) correlated to obesity (and in a patients with type 2 diabetes mellitus) and they have opposite effects on insulin sensitivity. Adipocytes secretes also adipsin, factor B and factor C. In-depth understanding of the pathophysiology and molecular actions of adipokines may, in the coming years, lead to effective therapeutic strategies
GINKGO BILOBA (Tanakan ) AND BIOELECTRIC ACTIVITY OF BRAIN IN HUMANS
Authors: Ivetić V. , Hodolič M. , Babić-Popović D. , Biševac B.
Published: November 2024

Ginkgo biloba is the oldest tree on the planet. Its healing characteristics have been weel known for more than 3000 years. The aim of this investigation to establish the influence of Ginkgo biloba extract (Egb 761 Tanakan) on bioelectric activity of brain in humans. 30 subjects aged from 52 to 56 years were included in study. The bioelectric activity (EEG) was registrated before and after three month therapy with Ginkgo biloba extract. The obtained results showed that summary bioelectric activity speeds up. Frequency of alpha rhytms increases significantly, number of desinchrayitation desreases, decreases number of non specific activity 
RADIOLOGICAL RADIOLOGICAL STUDY OF OSTEOMYELITIS OF OSTEOMYELITIS OF DIFFERENT DIFFERENT ETIOLOGY
Authors: Jovanović T. , Marković M. , Grbić R.
Published: November 2024

Authors analyse radiological characteristics of different forms of osteomyelitis in the period from 1990. to 1994. on Ortopedic and infective Clinic of Clinical hospital Centre in Pristina. Clinical picture of unspecific osteomyelitis of different forms, tubercular and brucellosis osteomyelitis is presented radiolography, tomography, myelography, fistulography, arteriography, scintigraphy, and computerized tomography. Radiological changes of osteomyelitis of different etiology and clinical picture are presented in detail
OUR EXPERIENCE WITH "CHEMET" MEDICATION, FIRST TIME USED IN EUROPE IN KOSOVSKA MITROVICA
Authors: Živković J. , Savić Z.
Published: November 2024

In two refugee camps, near K.Mitrovica (in little colliery city), gipsys refugees dislodge by Albanians were temporary located. In their blood, lead contamination is discovered. All together 310 children, 1-14 years old, were contaminated by lead. Examination and treatment is implement by the SZO patronage, which took capillar blood samples from 298 children and vein blood samples from 190 children. Level of lead, in 47 cases was more then 45 microgram./dl. All the children with high level of lead had physical and laboratory tests. Also, they were under special food diet, with a lot of calcium. In 45 cases, per os treatment is used with “Chemet” medication, produced by McNeil-USA.Only in 9 cases, week bad reaction was notice using this medication. In some isolated cases, headache, pain in stomach, sickness and sleepiness. This difficulties didn't required therapy cancelation. Treatment was fully successful except in two cases, where therapy was repeated.
BREAST CANCER IN ELDERLY
Authors: Dimić S. , Sekulić S. , Petrović D. , Dimić I.
Published: November 2024

Getting on in years individually becomes the biggest risk factor in appearance of the woman's brest cancer. From the entire number of new discovered woman's breast cancers, 48% are women older then age of 65. Woman's breast cancer discovered by persons got on in years diagnose in getting forward condition of illness besides bigger cancer freqvency with propitious histology and biological profile. There are not enough proper studies about the breast cancer in elderly. For the project development material has been used from the surgical clinic and clinic for Oncology, as wellas institute for Pathology of the clinical centre in the city of Nis.The data from our serial direct attention to rarer conduct of standard diagnostic procedures at elderly with breast cancer. Also the conectivity between years of the patients; and time being passing from the initial diagnosis until treatment has been studied. Using pathhistology exam we were reseiving information about histological type of cancer, about the size of cancer, histological and nuclear grade, as well as absence or hold of metastasis process of lymph nodus. The most frequent used surgical procedure was radical mastectomy modified by Madden and Patey. The presence of complications has been tracked in the postoperative progress. In the postoperative progress depending on condition of breast cancer histological and nuclear grade, hold of the lymph knots,positivism of hormonereceptors, presence of comorbidity female patientswere subjected to adjuvant therapy. With purpose of perception of diagnoses as well as caracteristics and results of treatment of the female patient's survival has been tracked. The average survival in the examined group was 21 months while it was 31 month in the control group
EDICINAL MEDICINAL FEATURES OF TURES OF OLIVE LEAF OLIVE LEAF (Olea europaea Olea europaea L.)
Authors: Dekanski D. , Janićijević-Hudomal S.
Published: November 2024

Interest in the olive leaf and its chemical constituents has recently been increasing. Its benefits, however, have been known for centuries, and it has been traditionally used to prevent and treat diseases. The main constituent of the olive leaves is oleuropeine one of iridoide monoterpenes, which is thought to be responsible for pharmacological effects. Furthermore, the olive leaves contain triterpenes including oleanolic and maslinic acid, flavonoides (luteolin, apigenine, rutin...), and chalcones (olivin, olivin-diglucoside). Its chemical content makes olive leaf one of the most potent natural antioxidant. Olive leaf is used to enhance the immune system, as an antimicrobial and in heart disease. Folk medicine uses also include hypertonia, arteriosclerosis, rheumatism, gout, diabetes mellitus, and fever. Recently, experimental animal studies have demonstrated hypoglycemic, hypotensive, antiarrhythmic, and vasodilator effects, as well as spasmolytic effect on the intestinal smooth muscle. Antibacterial, antiviral and antiinflammatory activity were also confirmed. The beneficial properties of olive leaf are further enhanced by the bioavailability of its polyphenolic constituents, which are readily absorbed through the gastrointestinal tract, resulting in significant levels in the circulation. Clinical studies to confirm experimental results are needed
RECOMBINANTACTIVATED FACTOR VIIa IN HAEMOSTASIS AFTER RADICALNEPHRECTOMYOFRENOCELULAR CARCINOMA
Authors: Jovanović P. , Ivanović D. , Timotijević S. , Trpković S. , Bojanović P. , Dobričanin V. , Cvetkoviċ M.
Published: November 2024

Important facts about recombinant human factor VIIa have been mentioned, also about the renal cell carcinoma. Case report: Male, aged 69, with infiltrative renal cell carcinoma, underwent radical nephrectomy using Hasagawa`s approach. Extirpated tumor had 35 cm in diameter. During the surgery, patient suffered a cardiac arrest with 3500 ml blood loss. After operation, he lost 2100 ml more blood. Despite of active blood supstitutions with intensive surgical attempts in order of haemostasis, bleeding did not stop untill the application of rFVIIa (300 I. U.). Patient survives and recovers completelly. Conclusion: RFVIIa is very succesful in controling of massive surgical bleeding, possibly associated with paraneoplastic syndrome.
TYPE 2 INFLUENCE TIAZOLIDINEDION ON GLICOREGULATION IN PATIENTS WITH DIABETES MELLITUS
Authors: Pajović S. , Jovanović A. , Novaković T. , Perić V. , Sovtić S. , Stolić R.
Published: November 2024

Diabetes mellitus with one`s chronical complications is the cause of the large percent morbidites and mortality, among the population. With regard to a lot of people who have diabetes mellitus tip 2 (WHO-over 170.000.000 peoples), adequate therapy is very important. By this stady, we wont to show positive consequence new therapy for medication diabetes mellitus typ 2, chiefly application tiazolidinedion in therapy. Handlend 25 patientis with diabetes mellitus typ 2 during 3-mounth observed. Patients were divide in II groups forms on basic of the kind therapy. At the end of 3-mounth, derived results (decrease HbA1c from 7.9%±1.24% to 6.99±0.89%; data value fasting glycemia from 8.99mmol/l±2.08 mmol/l to 7.45±1.35 mmol/l, and value glycemia after meal 10.36 mmol/l±2.18 mmol/l to 8.18 mmol/l±1.31 mmol/l) indicate validity the introduction tiazolidinedion in therapy diabetes mellitus type 2.
ENCE ON INADEQUATE DENTAL RESTORATION IN STATE OF PARODONTIUM INFLUEN
Authors: Matvijenko V. , Živković M. , Mitić N. , Videnović G. , Šubarić Lj. , Marjanović D. , Perić D. , Živković D.
Published: November 2024

After restoration of approximative cavities where gingive wall is forming subgingivaly occurs an damage of epitel of gingival sulcus and subepitel fibrous tissue. These damages occur partially in order of direct irritative effect of materials, and partially because of inadequately made definite reisen. Anomaly which may occur while making reisen, is effect of micro leakage between reisen wall of cavities roughness and reisen parts which prominate above anatomic tooth sphere , enable faster and bigger accumulating of dental plaque. Gingive inflammation is widening deeper in parodontium trough vascular network situated in interdental bone septum. Inflammation is constantly spreading from the point and reaches parodontium. The aim of this study is to estimate clinical changes in parodontium within certain group of patients of different age and sex, caused by inadequate dental restoration. Results of this research present that anomaly in dental reisen , have great influence on inflammation reaction of parodontium. Composite reisen cause higher degree of inflammatory reaction in compared to amalgam reisen
THЕ INFLUENCE OF EXTERNAL FIXATION TYP MITKOVIC ON LOWER LIMB`S POSTOPERATIVE EARLY RECOVERNG FUNCTIONALITY IN PATIENTS WITH FEMORALAND TIBIAL SHAFT FRACTURES
Authors: Božović A. , Jakšiċ M. , Adžić V. , Milović D. , Vasić A. , Petrović D. , Jakšiċ Lj.
Published: November 2024

The tibial and femoral shaft fractures representing prototyp in orthopedic traumatology and great problem for resolving. The speed of limb recovering functionality after surgery is important, and often desicisive for result of treatment. Place of external fixation (EF) in surgical treatment of femurs in DCOS (damage control orthopedic surgery), cominutions of femoral shaft and open fractures, rarely as definitive method. EF in treatment of tibial shaft fractures today take a place as a definitive method like intramedulary nailing. On department of orthopedic surgery in HC Kosovska Mitrovica we examined quality of life and speed of lower limb recovering functionality on 70 patients treated with EF tip Mitkovic as a definitive curative method. The time of achieving early function of lower limbs we divided on 4 levels, and writed time when patients achieved level 3 and 4. Also this timing we compared with middle time of healing tibial or femoral shaft fractures (golden standard) .We examined quality of life with EuroQol 5D evaluation system. 90% of our patient in period 8 to 12 weeks achieved level 3 and 4. There statisticaly significant diference between examined gropu and golden standard, p<0,05. We concluded that EF tip Mitkovic as definiyive curative method improved the speed of lower limbs recovering functionality. Quality of life is very high, 84 points. The number of complications where expected and in proportion with literatures data.
«NATURAL HISTORY OF DISEASE» - ESPECIALLY: MASS MANIFESTATION OF NATURAL SYSTEM OF PAROTITIS
Authors: Čukić G.
Published: November 2024

Prepathogenesis of mass occurrence of disease as a complex happening is hiding the “screen”. Social influence remained hidden inside school «25. may», which had as a consequence shown higher distribution of manifested disease. As the main point at performance of events is scientism based on “black box system”. There is uncritical trust in paradigm, statistic methodology there comes “parroting”. Sheltered by screen content of the events, between the enter of the first (sub)system and exit of the final (sub)system the most critical maintain “mixed approach”, with the aim to reveal into the real dynamics by “natural happening of mass disease”, into “driving force” that is causes of self moving - spontaneous genesis of epidemics: a) for mass effects of it is 'natural work' (appropriate according to another effect, with accidentally casual effect of helping of appearance of disease) which contributes coherence and consistence of contagion and man who can get disease - what will result with binary 'causative link'; while the following cause is important b) the appearance of disease: pathogenic of contagion will reflect only after previous appearance of permanent 'immanent causative link'. Reconstitution of epidemic is final act, recapitulation of familiar natural happening of concrete epidemic with anterograde chronology how the event itself happened.
PHARMACOECONOMICAL CHARACTERISTICS OF ANXIETY DISORDERS
Authors: Janjić V. , Đukić-Dejanović S. , Milovanović D. , Bukumirić Z.
Published: November 2024

Anxiety disorders are very common illnesses that are reported in approximately one third to one quarter of the entire population during the lifetime. Many anxiety disorders are being reported early in life, they have chronic progress, and cause significant difficulties, interfere in daily life activities and create huge economical expenses. It has been evaluated that 46.6 billion dollars out of 147.8 billion dollars overall mental disorders expenses in US is being spent on anxiety disorders, while in European community those expenses exceed 41 billion Euros. In spite of that, pharmacoeconomical aspects of these illnesses so far drawn much less attention than so called large mental illnesses (schizophrenia, depression), and the reason for that is probably that earlier relatively cheep benzodiazepines were dominantly used in treating anxiety disorders. However, in newer times the anti-depressives became the first choice for anxiety disorders, especially those from the group of selective serotonin reuptake inhibitors (SSRI). The increase of anxiety disorders prevalence and changes in modern pharmacotherapy create promising research conditions for starting the studies in area of pharmacoeconomics in the world, and in our country
STRATEGIES IN THE PREVENTION OF NONSTEROIDALANTIINFLAMMATORY DRUGS INDUCED COMPLICATIONS IN THE GASTROINTESTINAL TRACT
Authors: Dejanović B.
Published: November 2024

Nonsteroidal antiinflamatory drugs are currently one of the most widely used categories of drugs, because there is a huge number of indication for theirs purpose. This huge purpose of this drugs has theirs own price, which is shown in side effects, especialy in the upper parts of gastrointestinal tract: erosions of the mucose in 35-60 %, ulcers in 10-25%, strong bleeding or perforation in <1%. It is appears that this drugs are responsible for 10-20 thousands lethal outcome in the world. Even small dose of acetlisalicil acid by 75 mg,which is used in prevention of cardiovascular disease, brings to the damage of mucose GIT and 11% have ulcer. Inhibition ciklooxigen-1,which have main role in protection mucose of stomach and duodenum on the part of NAIL, lead to damage mucose GIT, and that is the result of sistemic inhibition, which is indenpendant of the way of getting drugs. Some author instigate a local effect of Nail,as week acid. It is necessary to protect highrisk pacient with using gastroprotektiv drugs
A-MOD ULTRASONOGRAPHYIN DIAGNOSIS OF MAXILLARYSINUSES DISEASES
Authors: Belić B.
Published: November 2024

There are many forms of physical energy which, during such a short period of time, had rich history and which found wide application in the science of medicine, as was the case with the ultrasound in the last fifty years or so. The ultrasound got its affirmation rather soon, as valuable biologically harmless method used for detecting and explaining various pathological conditions in the science of medicine, and therefore in otorhinolaryngology as well. In the following study, the technique of the ultrasound examination of paranasal sinuses is described in details, standard echogramic patterns are
represented, and means of their interpretation are explained as well, regarding the fact that it is not standard. Special focus is
on the literature review whereby the valorization of the ultrasonography in relation to acute and chronic diseases of the maxillary sinuses is performed. In that sense, over 30 extracts by the authors from all parts of the world are represented. The
insight into the results of the latter reports, as well as the author own experiences, lead to the conclusion that the A-mode
ultrasonography represents an impartial method applicable in diagnostics of the maxillary sinus diseases. It is practical and
economical for it is performed quickly and in a rather simple manner. It is an invasive and painless method, comfortable for
the patient. Main advantage in relation to other radiological methods lies in the avoidance of the patient and medical doctor's
exposure to X-rays, therefore the ultrasonography method is a matter of choice for diagnosis of primarily maxillary sinus
acute diseases with children and pregnant women. Due to extraordinary sensitivity in the evaluation of the sinus secret, with
acute diseases it represents valuable, impartial supplementary method. On the other hand, due to weaker peculiarity, with
chronic diseases ultrasonography only represents a selective method
CHILDREN WITH PROTENURIA
Authors: Živković J.
Published: November 2024

Work construe problems in children's protenuria.It is about physiology, pathological and insulated protenuria, also observation of examination stages of children with protenuria. It is about glomerul filtration and ultrafiltration barrier. Histochemical aspect show us that membrane is between palmately extensions and electromicroscopically aspect which indicate on subendotel part of basic membrane. About tubular absorption and removing of albumin from primary ultrafiltrate. Work is about proximal tubul and mechanism for reabsorption and transport of protein and peptid. Pathological protenuria is segmented on glomerul,tubul,hiper-production/overflow,and histuria. Work contains protenuria in different forms, transitiv, ortostatic and persistence. There are prepositions of three phases in examinations of protenuria
EOSINOPHILIC GRANULOMA HYSTIOCYTOSIS X
Authors: Novaković T. , Tomić S. , Stojević Z. , Krdžić J. , Jovanović A. , Pajović S. , Stolić R.
Published: November 2024

Eosinophilic Granuloma (EG) represent the most benign and localized form of the three Langerhans cell histiocytosis syndromes. In bone, it is a tumor-like proliferation Langerhans cells. Intraosseous EG lesions can be solitary or multifocal. EG accounts for 60-70 % of Langerhans cells histiocytosis cases. The authors are describle a 21 year-old men with Eosinophilic granuloma. The disease had a rarely course with disorders multiple lesions in bones
THE HIST THE HISTORY OF CHEMISTR CHEMISTRY SERVICE IN KOSOV VICE IN KOSOVO AND MET AND METOHIJA
Authors: Stanić M. , Stašić D. , Rakić D. , Zakić S.
Published: November 2024

The biggest Serbian medival hospital had founded Stefan Urosh III Nemanjich in the monastery named Dechani. In 1340, it had been founded the hospital of the emperors Dushan in monastery of St.Arhangel near tawn Prizren. By liberation of the province Kosovo and Metohija from the Turkish rule and by united with Serbia,the health had been diveloping in this region. In 1922, it had been founded the state hospital in 1931. Governor, and in 1938, this hospital had the 120 beds and three laboratory rooms for analyses of blood and of urine. In 1924, it had been formed the first bacterologist station in Prizren. In 1928, it had been formed the State childrens home which is in 1929. had been become public health station with the general school ambulanta first aid station,bathroom and laboratory. In 1927. it had been working the Polyclinic in Prishtina were theyhad been carrying on the laboratory analyses.In these health resorts in the province of Kosovo and Metohija have been carrying on the analyses of blood, urine and of bowel as and the microscopy of preparation to malaria and it has been carrying on the education of skilled workers for these analyses. After the Second World war it had been carrying on the education of laboratory technians it the courses and by opening of laboratories in hospitals and health stations in Kosovo and Metohija the specialization of medicine biochemistry have been ending a lot of pharmacists who give a famous contribution to the development of biochemistry in this territory.
THE INFLUENCE OF GENERALANAESTHESIA ON CHANGES ОF ARTERIAL OXYGEN SATURATION SaO2 IN CIGARETTE SMOKERS
Authors: Pavlović A. , Trajković G. , Videnović N. , Jovanović A.
Published: November 2024

Although there is generally world trend in decreasing of number of smokers, expecially in developed part of world, smoking cigarettes still have large importance in morbidity and mortality of modern human population. Taking anamnestics data about smoking habit instruct anaesthesiologist to apply special strategy in general anaesthesia for a reason of possible complications provoked bby a chronic influence of nicotin and other tobbaco ingredients on different organs. In this article we wanted to examine influence of chronic tobbaco smoke exposing on arterial oxygen saturation SaO2 during and short period after general anaesthesia. Research was evaluated on patients in Emergency Center of Clinical Center of Serbia. Patients were divided in two groups (ASAI and II): group I smokers (n=40) and group II nosmokers (n=40). Our investigation has shown no statistical significant difference on SaO2 during general anaesthesia between two experimental groups. Immediately after general anaesthesia and extubation in postoperative period SaO2 dicreases (p<0.001) during transport from operating room to recovery room in both groups of patients,but the level of hypoxemia was significantly higher in smokers group. In this study we demonstrated that tobbaco smoking corellate with postoperative decrease of SaO2 after general anaesthesia, proposing an additional oxygen therapy in early postoperative period.
EPIDEMIOLOGICAL EPIDEMIOLOGICAL FEATURES OF TURES OF TULAREMIA TULAREMIA IN SERBIA IN SERBIA
Authors: Parlić M. , Milić N. , Vukadinović Z. , Stevanović J. , Stolić A. , Samardžić S.
Published: November 2024

Aim of this study was to identify the most relevant epidemiological risk factors for acquiring tularemia. Method used in the study was cross section. During period 2000-2006 at the territory of Serbia (excluding Kosovo and Metohia region) 254 tularemia cases were identified. No lethal outcomes were noted. Tularemia was registered in 11 districts of Central Serbia, while no cases of the disease were noticed in region of Vojvodina. In Serbian enclaves in Kosovo and Metohia there were 4 cases of Tularemia. 4 epidemics with 21 diseased persons were reported at territory of Central Serbia. Majority of patients were 20-60 years old (86%). No significance difference in sex distribution was observed. Almost the same number of male (129) and female (125) patients was affected. This could be explained by identical exposure of both sexes to diseases causative agents. The disease has seasonal character. It occurs most often in late autumn and winter due to contact with diseased rabbits during hunting season, meat consummation, and inhalation of dust containing diseased animal excreta. During observation period linear trend of incidence rate have not shown statistically significant elevation neither decrease.
MIGRAINE COMBINED WITH ACM ANEURISM IN 15 YEARS OLD PATIENT CASE PRESENTATION
Authors: Čolić S. , Smiljić Lj. , Nenadović M. , Trajković G. , Marjanović J.
Published: November 2024

Migraine headaches are very frequent and its prevalence rates between 15-18% in women and 5-6% in men (1). Migraine attacks vary very mach in their intensity and frequency from patient to patient, and during the time in same patient. Even 75% of the patients describe attacks as heavy or extremely heavy. Although somatic and neurology exams between attacks reveal regular findings, migraine can have great impact on the patients quality of life (social limitations, complications caused by drugs, psychiatric and somatic morbidity (2) In spite usual believes headaches are very often in children. Before puberty boys safer more frequently than girls. Just the same, in early childhood as well as in adolescence migraine pain could mimic and compromise bringing up the right diagnosis of the other possible somatic causes, most likely one sided headaches. Our case presentation points out one of the possibilities. L.M 15-years old patient hospitalized on the pediatric department of the ,,Kralj Milutin Clinic,, in Laplje Selo on October 2007, under the diagnosis of blanking out and left sided headache. After neurology exam and neurology diagnostic procedures done MR cerebra and MR-angiography, diagnose of aneurism of right the ACM (arteria cerebra media) has been established, and operatively treated. After the intervention, patient stays without intensive headaches , only weak pain on the left side of the head, now and on, without blanks.
PSYCHOTICISM PSYCHOTICISM AS AN ETYOLOGICAL ETYOLOGICAL FACTOR OF POLITOXICOMANIA OXICOMANIA
Authors: Šapić R. , Krivokapić Ž. , Nenadović M.N. , Trajković G.
Published: November 2024

The psychotropic drug addiction is steadily increasing in the subpopulation of the young generation. The objective of this paper is to investigate the degree of psychoticism as a disintegrating personality phenomenon. Psychoticism comprises elements of autism, insensitiveness, aggression, asocialisation. This irregularity in cognitive processes was tested on three groups of people: politoxicomaniacs, psychotic patients and a control group. The DELTA test reported convincingly raised dimensions on the scale of psychoticism: general executive functions (GEI), schyzotypical behaviour (SHD) , paranoia (P), and depression (D), as crucial factors not only for developing addiction but also for achieving long - term and stable abstinence. Apilot study retesting of abstinent persons, has confirmed, after a year's treatment, the change in their behaviour ( by improving all the results on DELTAscale of psychoticism).
THE FRACTURES OF THE LOWER LEG AND HEALTHING THE FRACTURES WITH EXSTERNAL FIKSATER BY MITKOVICH USING THE CLOSED
Authors: Vasić A. , Jakšiċ M. , Adžić V. , Milović D. , Božović A. , Petrović D. , Jakšiċ Lj.
Published: November 2024

The fractures of the tibia are mainly the fractures of the long bones. In the department of the orthopedic in Kosovska Mitrovica, 45 of patient with fracture of the lower leg had been treated with using the closed method. It had been the linear fractures in the 84% of the treated cases.The most number of the patients were treated in the hospital for 5 days. In our healing we are noticed the folowed complications in the treated patients: the major infections around the pin were in the 4% of the treated patients (2 patients),the fat embolism were in the 2% of the treated patients (1 patient),the pseudoarthrosis were in the 4% of the treated patients (2 patients). Aplication the extrafocal fixat r by Mitkovich using the closed method made possible that the fracture became stable in fast and simply way with the minnor invasion at the soft tissues and with this are made the conditions for splicing of the fractures.
EPILEPTIC STATUS AND THERAPY
Authors: Petrović N.T. , Mitić R. , Mitrović V.S. , Milošević N.M. , Krivokapić M. , Jakovljević M.
Published: November 2024

Epileptic status is one of the most urgent conditions in medicine, whose positive outcome is directly dependent of adequate treatment. The estimation of epileptic status incidence is not available. According to population studies, the incidence varies from 16 to 18 at a sample of 100000 people. The status treatment consists of a line of procedures whose goal is to stop it in as little time as possible. Medication therapy is the basis of it, and it is needed that intravenous medications are used urgently in an adequate dose, at an adequate speed (intravenous burden dose), with an adequate symptomatic therapy and correction of eventual provocation status factors. General medications used to initially treat the status are benzodiazepines, fenitoin and fenobarbiton. Randomized studies have shown that lorazepam has pharmacokinetic advantages over diazepam and that it doesn't initiate respiratory depression as often as midazolam. Also, it is more efficient than fenitoin, and more efficient than fenobarbiton. Medication treatment is confirmed to be efficient at breaking the status at nearly all of the patients, but the final outcome depends on the initial cause. If the status cannot be ended by application of conventional doses of basic medications, then a refractory status may be discussed. It may be treated by a prolonged anesthesia using barbiturates, midazolam or lorazepam.
CORRELATIONS BIOCHEMICAL VARIABLES OF ASPIRIN AND TICLOPIDINE ADMINISTERED ALONE AND IN COMBINATION IN RATS
Authors: Stanojević Z. , Mitić R. , Nestorović V. , Stević S. , Bukumirić Z. , Bulajić S.
Published: November 2024

A combination of aspirin and ticlopidine has been proven to reduce the frequency of haemorrhagic and vascular complications after coronary artery stenting. Also, ticlopidine is often associated with hyperbilirubinemia and abnormal liver function test values. The purpose of this study was to evaluate the correlations between biochemical variables (serum total cholesterol levels, total bilirubin concentration, serum activities of alkaline phosphatase and alanine- ALT and aspartate- AST aminotransferases) of aspirin and ticlopidine administered alone and in combination. The experiment was conducted on white laboratory rats, type Wistar. Thirty-two rats were divided in four groups and they received one of the following treatments for three days: group I - control, saline (1 ml/kg, i.p.); group II - aspirin (50 mg/kg/day i.p.); group III - ticlopidine (125 mg/kg/day i.p.) and group IV - aspirin+ticlopidine combination (50 mg/kg/day+125 mg/kg/day i.p.). Biochemical variables were determined at once after taking the sample of blood. Relationship between two measured variables was determined by calculating linear correlation coefficient (r). Between total cholesterol level and AST activity in control group of rats was noticed negative and low correlation (r=-0,27); in group treated with aspirin negative, high and significant correlation (r=-0,86); in group treated with ticlopidine negative and low correlation (r=-0,24); and in group treated with aspirin+ticlopidine combination positive, high and significant correlation (r=0,79). Between other investigated variables were not noticed significant correlation in all treated groups. Based on obtained results it can be noticed that negative correlation between serum total cholesterol level and AST activity in control, aspirin and ticlopidine groups becomes positive and significant only after the treatment with aspirin+ticlopidine combination.
THE MOST OFTEN PATHOLOGICAL CHANGES OF VULVA CAUSED WITH HUMAN PAPILLOMA VIRUSES (HPV)
Authors: Vukićević D. , Perišić Ž. , Plešinac-Karapandžić V. , Vančentović-Mijović M. , Đerković B. , Vitković L. , Mitić N.
Published: November 2024

Vulva can easily be examined, therefore it could be expected that any changes that may emerge at it would be easy
to notice and treat quickly and efficiently. Despite that, the incidence of pre-malignant and malignant changes is increasing.
Many risk factors connected to the emerging of these changes have been discovered, but many explanations have become
available only when the theory of the participation of HPVin oncogenesis has been set. The goal of the study is to identify all
the pathological changes at vulva - benignant, pre-malignant and malignant, according to the age of the patients, and
therefore, both biopsy and operational material collected from 1331 patients treated at GAK “Narodni Front” Belgrade, has been used. There have been 46 diagnoses of benignant changes, of which 20 (43,48%) had been diagnosed as condylomata acuminata, a change including a HPV infection. Most of these changes have occurred at patients aged 31-40. In 17 cases of pre-malignant changes, VIN I has occurred in 2 cases (11,76%), and VIN II and VIN III as more serious pre-malignant lesions were noticed in 8 samples. In 7 cases (41,18%), VIN III was discovered to be moving into a starting invasion phase. It can be concluded that VIN is most often at patients aged over 60. Malignant vulva tumors occurred in 14 cases, 13 of those where diagnosed as invading planocellular carcinoma, and one of them was metastatic. Vulva carcinomas seem to occur most often at patients aged over 60.