bluuebunny/crossref_metadata_2025 huggingface dataset:
The Self-Inflicted Dimensions of Puerto Rico’s Fiscal Crisis
Authors: Quiñones-Pérez Argeo T. , Seda-Irizarry Ian J.
Published: April 2020

The fiscal crisis in Puerto Rico, which constrains the ways in which the government can try to tackle the economic depression, is in important ways self-inflicted—the product of economic policies undertaken at the local level. When the crisis is approached in this way, the resolution of the island’s colonial situation can be seen as a necessary but not sufficient condition for solving the problems of the depression’s victims.

La crisis fiscal en Puerto Rico, que limita las formas en que el gobierno puede potencialmente tratar de hacer frente a la depresión económica, es autoinfligida de manera importante: el producto de las políticas económicas implementadas a nivel local. Cuando se aborda la crisis de esta manera, la resolución de la situación colonial de la isla puede verse como una condición necesaria pero no suficiente para resolver los problemas de las víctimas de la depresión.
Influence on mechanical and rheometric properties through different methods of chemical modification of silica applied to natural rubber compounds
Authors: Rombaldi Samuel H , Pierozan Nilso José , Brandalise Rosmary N
Published: April 2020

The chemical modification of fillers has been an alternative to reach new levels of mechanical and rheometric properties. In this study, three methods of chemical modification of silica Zeosil 1165 PM, used as a reinforcing filler in elastomeric formulations, were evaluated by using the organosilane coupling agent, bis-(3-triethoxysilylpropyl) tetrasulphane (TESPT) compared to the reference, without addition of the TESPT named F1. The modification methods adopted were the chemical modification of the time-temperature-controlled greenhouse silica, named F2, the modification of the silica in the Banbury mixing process, named F3, and the use of the nanoclay-modified silica and incorporation of the TESPT in Banbury, named F4. Modification of greenhouse silica was monitored by thermogravimetry and Fourier-transform infrared spectrophotometry to define the modification parameters used for further incorporation of the filler in Banbury. Regarding the morphological properties, a large reduction of silica aggregates and agglomerates in TESPT formulations was evidenced by scanning electron microscopy, ranging from 100 nm to 500 nm (F1) to aggregates below 100 nm (F2, F3, and F4). On the other hand, improvements in rheometric, rheological, physical, and mechanical properties were also observed, comparing F2, F3, and F4 with F1, such as a reduction in Mooney viscosity by 40.2%, 51.1%, and 47.8%, a reduction in the optimal cure time by 41.1%, 48.9%, and 44.4%, a reduction in permanent deformation by 47.1%, 31.3%, and 41.6%, an increase in hardness by 15.3%, 16.4%, and 21.6%, increase in the reinforcement character by 32.4%, 51.7%, and 66.0%, and an increase in resistance to traction by 26.6%, 16.1%, and 63.9%. The best results for reinforcing character and tensile strength were verified in the modified nanoclay silica (F4). Thus, all results converge to a significant improvement in the properties of the formulations with the use of TESPT.
Resisting subalternity: Palestinian mimicry and passing in the Israeli cultural industries
Authors: Jamal Amal , Lavie Noa
Published: April 2020

This article explores the complexity of minority creative workers in the media industry. It challenges the common notion in the literature that minority creative workers are fully submissive to the dominant power structure and examines whether such workers could still be conceived as active agents by resisting submission and marginalization even when they cannot influence their own representation in hegemonic media texts. To answer this question, it explores the performances of minority creative workers in a hegemonic cultural industry. To determine whether one can speak of subaltern agency and, if possible, examine how it manifests itself in reality, it addresses the daily performances of Palestinian creative workers during the production of the second season of the Israeli television series, Fauda. Observations conducted during production demonstrate that since in such contexts minority creative workers cannot avoid being projected in negative roles in the media text, they adopt creative subversive practices of passing and transgressive mimicry, resisting full compliance with the production, without endangering their own position. By doing so, the article contributes not only to the emerging field of creative entrepreneurship in cultural production, but also enables determination of common practices of creative subversion in the cultural industries.
British Skull Base Society Clinical Consensus Document on Management of Head and Neck Paragangliomas
Authors: Lloyd Simon , Obholzer Rupert , Tysome James ,   BSBS Consensus Group
Published: April 2020

The management of head and neck paragangliomas (HNPGLs) has changed significantly in recent years. There is, however, an absence of guidance in the literature regarding the optimal means of managing this challenging disease. This consensus document, developed by the British Skull Base Society, sets out recommendations for management of HNPGLs. A preliminary document was produced on the basis of current practice in 3 large UK skull base centers, incorporating relevant peer‐reviewed evidence. This document was then modified by discussion within these units, through a national survey of British Skull Base Society members, and through discussion with stakeholders. A consensus was reached on the management of all forms of HNPGL. All patients should be managed by a multidisciplinary team and require initial surgical, endocrine, and genetic assessments as well as magnetic resonance imaging of the head, neck, chest, abdomen, and pelvis. Long‐term preservation of function is the primary treatment goal, with conservative management the first choice treatment for most tumors. Radiotherapy is a safe, effective treatment for growing tumors in most cases, although there is a limited role for surgery. Screening of family members in high‐risk groups is mandatory. These guidelines should help standardize high‐quality care for patients with HNPGLs.
Contralateral Tongue Muscle Activation during Hypoglossal Nerve Stimulation
Authors: Sturm Joshua J. , Modik Oleg , Koutsourelakis Ioannis , Suurna Maria V.
Published: April 2020

Objective

The effectiveness of upper airway stimulation via hypoglossal nerve stimulation for obstructive sleep apnea depends upon the pattern of tongue muscle activation produced. This study investigated the nature of contralateral tongue muscle activation by unilateral hypoglossal nerve stimulation using intraoperative nerve integrity monitoring in conjunction with electromyography and explored the relationship between contralateral tongue muscle activation and polysomnographic measures of obstructive sleep apnea severity.

Study Design

Prospective case series.

Setting

Tertiary care medical center.

Subjects and Methods

Fifty‐one patients underwent unilateral (right) hypoglossal nerve stimulator implantation for obstructive sleep apnea. Neurophysiological data included electromyographic responses in ipsilateral (right) and contralateral (left) genioglossus muscles in response to intraoperative bipolar probe stimulation (0.3 mA) of medial hypoglossal nerve branches. Clinical data included pre‐ and postoperative apnea‐hypopnea indices and oxygen desaturation levels.

Results

A subset of patients (20/51, 39%) exhibited electromyographic responses in both the ipsilateral and contralateral genioglossus (bilateral), whereas the remaining patients (31/51, 61%) exhibited electromyographic responses only in the ipsilateral genioglossus (unilateral). The baseline characteristics of bilateral and unilateral responders were similar. Both groups exhibited significant and comparable improvements in apnea‐hypopnea index and oxygen desaturations after hypoglossal nerve stimulation. Neither the amplitude nor the latency of contralateral genioglossus responses was predictive of clinical outcomes.

Conclusion

A subset of patients undergoing unilateral hypoglossal nerve stimulation exhibits activation of contralateral genioglossus muscles. Patients with unilateral and bilateral genioglossus responses exhibit comparable, robust improvements in apnea‐hypopnea index and oxygen desaturation levels.
Best Practice Recommendations for Pediatric Otolaryngology during the COVID‐19 Pandemic
Authors: Bann Darrin V. , Patel Vijay A. , Saadi Robert , Goyal Neerav , Gniady John P. , McGinn Johnathan D. , Goldenberg David , Isildak Huseyin , May Jason , Wilson Meghan N.
Published: April 2020

Objective

To review the impact of coronavirus disease 2019 (COVID‐19) on pediatric otolaryngology and provide recommendations for the management of children during the COVID‐19 pandemic.

Data Sources

Clinical data were derived from peer‐reviewed primary literature and published guidelines from national or international medical organizations. Preprint manuscripts and popular media articles provided background information and illustrative examples.

Methods

Included manuscripts were identified via searches using PubMed, MEDLINE, and Google Scholar, while organizational guidelines and popular media articles were identified using Google search queries. Practice guidelines were developed via consensus among all authors based on peer‐reviewed manuscripts and national or international health care association guidelines. Strict objective criteria for inclusion were not used due to the rapidly changing environment surrounding the COVID‐19 pandemic and a paucity of rigorous empirical evidence.

Conclusions

In the face of the COVID‐19 pandemic, medical care must be judiciously allocated to treat the most severe conditions while minimizing the risk of long‐term sequelae and ensuring patient, physician, and health care worker safety.

Implications for Practice

The COVID‐19 pandemic will have a profound short‐ and long‐term impact on health care worldwide. Although the full repercussions of this disease have yet to be realized, the outlined recommendations will guide otolaryngologists in the treatment of pediatric patients in the face of an unprecedented global health crisis.
The Anthropocene stinks! Odor, affect, and the entangled politics of livestock waste in a rural Iowa watershed
Authors: Neubert Christopher
Published: April 2020

Recent interventions in geography regarding the Anthropocene have demonstrated how Western logics of order and containment have produced massive geologic transformations. This paper focuses on odor as a sense that, when engaged critically, disrupts those logics by exposing the porousness of the body to other bodies and spaces. Visceral reactions to smell produce affective responses in the body which are informed by circulating political discourses. Thus, this paper explores how research focused on odor can reveal the complicated dynamics through which bodies are enrolled into subject formation and become a terrain of political struggle. Research on the everyday experience of hog manure in a rural Iowa watershed forms the case study through which these questions are raised. Since the transition to concentrated livestock agriculture at the end of the twentieth century, the disposal of animal waste has caused serious concern. This waste is often collected and later spread on fields across the state, producing foul odors and potential toxins. Political discourses that maintain this system claim waste is ordered and properly maintained, generating positive affective responses to foul odors and thereby maintaining support for industrialized agriculture.
Social media and inclusive human development in Africa
Authors: Asongu Simplice A. , Odhiambo Nicholas M.
Published: April 2020

This study investigates the relationship between social media and inclusive human development in 49 African countries for the year 2012. Social media is measured with Facebook penetration whereas inclusive human development is proxied by the inequality- adjusted human development index. The empirical evidence is based on Ordinary Least Squares, Tobit and Quantile regressions. Ordinary Least Squares provided baseline results, Tobit regressions account for the limited range in the outcome variable while Quantile regressions are engaged to control for initial levels of inequality-adjusted human development. From Ordinary Least Squares and Tobit results, Facebook penetration is positively associated with inclusive human development. Quantile regressions confirm this positive nexus and further establish that the positive association is slightly higher in magnitude in the above-median sub-sample. From a comparative assessment, it is apparent that with the exception of the resource-wealth sub-samples, higher levels of Facebook penetration are associated with comparatively higher levels of inclusive human development. Accordingly, the positive association between Facebook penetration and inclusive human development is: (i) a positive function of income levels and (ii) more apparent in Middle East and North African countries (compared to Sub-Saharan African countries), English common law countries (compared to their French civil law counterparts), and coastal countries (in relation to landlocked countries).
Efficacy of transcutaneous electrical acupoint stimulation combined with diazepam for acute alcohol withdrawal syndrome: A double-blind randomized sham-controlled trial
Authors: Song Yun , Xue Xiaobin , Han Haibin , Li Cuiluan , Jian Jia , Yuan Wei , Chen Xu
Published: April 2020

Objective

To compare the efficacy of transcutaneous electrical acupoint stimulation (TEAS) combined with diazepam against diazepam alone for treatment of acute alcohol withdrawal syndrome (AWS).

Methods

In this double-blind randomized sham-controlled trial, men with acute AWS were randomly allocated to either a group treated with TEAS combined with diazepam (n = 57) or a control group treated with sham TEAS combined with diazepam (n = 60). Treatment was performed at four acupoints twice a day for 14 days. The Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar), visual analogue scale (VAS), Pittsburgh Sleep Quality Index (PSQI) and modified Epworth Sleepiness Scale (mESS) were used to evaluate treatment efficacy.

Results

All scores improved significantly in both groups during the trial. CIWA-Ar scores were lower in the TEAS group than in the control group from day 3 until the end of observation. VAS and mESS scores were also lower in the TEAS group than in the control group on day 7. VAS and PSQI scores were lower in the TEAS group on day 14.

Conclusion

Combining diazepam with TEAS may result in milder AWS symptoms than diazepam alone, improve sleep quality and reduce sleepiness.
Playing favourites: Israel and Judah in the marriage metaphor of Jeremiah 3
Authors: Crouch C L
Published: April 2020

The depiction of Yhwh’s marriage to Rebellious Israel and Treacherous Judah in Jeremiah 3 has resisted interpretation in terms that cohere with the text’s surroundings or our wider historical and theological understanding of the entities named by the text. Though commentators consistently identify the sisters as the northern and southern kingdoms, they are obliged to engage in interpretive gymnastics to explain the text’s preference for Israel, the northern kingdom. This article examines recent interpretations and their underlying assumptions, then reviews immediate and wider evidence for the entities called Israel and Judah, en route to a new proposal for their identification and significance in this passage. It proposes that the apparent incoherence of the allegory and its relationship with the surrounding material may be resolved by the recognition that Israel is meant to signify the community exiled to Babylonia, while Judah represents those left behind in the land.
Positive nasal Staphylococcus aureus polymerase chain reaction assay is not sensitive in predicting concurrent or subsequent Staphylococcus aureus infection in critically ill patients
Authors: Kanagasingham Kalai C , Ho Kwok M , Robinson J Owen
Published: April 2020

Staphylococcal infection is associated with significant morbidity and mortality in critically ill patients. Using data from 16,681 patients who had a nasal Staphylococcus aureus polymerase chain reaction (PCR) assay on admission to the intensive care unit (ICU) of Royal Perth Hospital between March 2006 and September 2016, this retrospective cohort study assessed whether nasal S. aureus colonisation on admission to an ICU was predictive of concurrent or subsequent S. aureus infections. Culture-proven S. aureus infections were identified using the hospital microbiology database. Of the 16,681 patients included, 565 (3.4%) had a positive methicillin-resistant S. aureus (MRSA) assay, 146 (0.9%) had a positive methicillin-sensitive S. aureus (MSSA) assay and eight (0.05%) had both positive MRSA and MSSA assays. Of those 565 patients with a positive MRSA PCR assay, 79 (13.8%) had concurrent or subsequent MRSA infections. Of those 146 patients with a positive MSSA PCR assay, only 5 (3.4%) had MSSA infection. The sensitivity and specificity for the MRSA PCR assay in predicting concurrent or subsequent MRSA infection were 72.7% (95% confidence intervals (CI) 63.4%–80.8%) and 97.0% (95% CI 96.8%–97.3%), respectively. The sensitivity and specificity for the MSSA PCR assay in predicting concurrent or subsequent MSSA infection were 3.3% (95% CI 1.1%–7.6%) and 99.1% (95% CI 98.9%–99.2%), respectively. Both nasal MRSA and MSSA PCR assays had a high specificity and negative predictive value in predicting MRSA and MSSA infections, respectively, suggesting that in centres without endemic S. aureus infections, a negative nasal MRSA or MSSA PCR assay may be useful to reduce unnecessary empirical antibiotic therapy against S. aureus.
Assessment of immunogenicity from galcanezumab phase 3 trials in patients with episodic or chronic migraine
Authors: Martinez James M , Hindiyeh Nada , Anglin Greg , Kalidas Kavita , Hodsdon Michael E , Kielbasa William , Moser Brian A , Pearlman Eric M , Garces Sandra
Published: April 2020

Background

This analysis characterizes the immunogenicity profile of galcanezumab, a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide and inhibits its activity, in phase 3 migraine trials.

Methods

Immunogenicity data were analyzed from baseline and double-blind, placebo-controlled phases of the 3-month chronic migraine study REGAIN, the 6-month episodic migraine studies EVOLVE-1 and EVOLVE-2, and from baseline and open-label phases of the 12-month chronic and episodic migraine Study CGAJ. The incidence of baseline antidrug antibodies, treatment-emergent antidrug antibodies, neutralizing antidrug antibodies, and the effect of antidrug antibody titer on pharmacokinetics and pharmacodynamics were assessed. The relationship between antidrug antibody status and efficacy was explored using average change in monthly migraine headache days. Safety analyses assessed the potential relationship between treatment-emergent antidrug antibodies and hypersensitivity events or adverse events related to injection sites.

Findings

Across studies, 5.9–11.2% of patients had baseline antidrug antibodies. The incidence of treatment-emergent antidrug antibodies was 2.6–12.4% in the galcanezumab group and 0.5–1.7% in the placebo group. The majority of treatment-emergent antidrug antibodies were detected approximately 3–6 months after first study drug dose. Overall, the observed antidrug antibody titer did not impact galcanezumab concentrations, calcitonin gene-related peptide concentrations, or galcanezumab efficacy. There was no evidence that hypersensitivity events or adverse events related to injection sites were mediated by treatment-emergent antidrug antibodies.

Interpretation

These data showed that immunogenicity did not impact galcanezumab concentrations, calcitonin gene-related peptide concentrations, or the efficacy and hypersensitivity profile of galcanezumab in patients with migraine.
Elimination of glycopeptide antibiotics by cytokine hemoadsorption in patients with septic shock: A study of three cases
Authors: Dimski Thomas , Brandenburger Timo , MacKenzie Colin , Kindgen-Milles Detlef
Published: April 2020

Sepsis and septic shock are characterized by a release of cytokines into the circulation. These mediators contribute to the detrimental hemodynamic and metabolic effects in the early phase of septic shock. Recently, a new polystyrene-based hemoadsorption device was introduced into clinical practice (CytoSorb®). The adsorber binds a variety of molecules including cytokines and removes them from the circulation. Studies in septic patients have shown an improved clinical course following hemoadsorption but no increased survival. We hypothesize that not only cytokines but also antibiotics may be removed which potentially may negate any beneficial effect of the adsorber. To test this hypothesis, we performed polystyrene-based hemoadsorption in three patients in septic shock and analysed glycopeptide elimination by measuring serum levels pre- and post-adsorber. We administered both teicoplanin and vancomycin via a 60-min infusion and vancomycin via continuous infusion, additionally. When applied as 60 min infusion, vancomycin and teicoplanin were removed immediately by the adsorber. However, the adsorptive capacity of the device was saturable. Serum levels of vancomycin, but not teicoplanin, decreased to subtherapeutic levels. With continuous infusion of vancomycin, removal was less and serum levels remained in the therapeutic range. In conclusion, we show effective glycopeptide adsorption using a polystyrene-based hemoadsorber in septic patients. The dose of these antibiotics should be adjusted appropriately and early therapeutic drug monitoring is highly recommended.
Latinx Millennials: Enduring Issues and New Challenges
Authors: Hondagneu-Sotelo Pierrette , Estrada Emir , Flores Edward O. , Flores Glenda M.
Published: April 2020

This essay focuses on the diversity of Latinx millennials. As sociologists, each one of us has conducted primary research on particular segments of Latinx millennials, and we draw on our respective research to identify enduring, ongoing issues confronting Latinx young people, analyzing and comparing what we see today with experiences of Latinx young people in the past. Along the way, we review scholarship on Latinx millennials, and we conclude by suggesting critical avenues for future research.
Machine learning predictions on fracture toughness of multiscale bio-nano-composites
Authors: Daghigh Vahid , Lacy Thomas E , Daghigh Hamid , Gu Grace , Baghaei Kourosh T , Horstemeyer Mark F , Pittman Charles U
Published: April 2020

Tailorability is an important advantage of composites. Incorporating new bio-reinforcements into composites can contribute to using agricultural wastes and creating tougher and more reliable materials. Nevertheless, the huge number of possible natural material combinations works against finding optimal composite designs. Here, machine learning was employed to effectively predict fracture toughness properties of multiscale bio-nano-composites. Charpy impact tests were conducted on composites with various combinations of two new bio fillers, pistachio shell powders, and fractal date seed particles, as well as nano-clays and short latania fibers, all which reinforce a poly(propylene)/ethylene–propylene–diene-monomer matrix. The measured energy absorptions obtained were used to calculate strain energy release rates as a fracture toughness parameter using linear elastic fracture mechanics and finite element analysis approaches. Despite the limited number of training data obtained from these impact tests and finite element analysis, the machine learning results were accurate for prediction and optimal design. This study applied the decision tree regressor and adaptive boosting regressor machine learning methods in contrast to the K-nearest neighbor regressor machine learning approach used in our previous study for heat deflection temperature predictions. Scanning electron microscopy, optical microscopy, and transmission electron microscopy were used to study the nano-clay dispersion and impact fracture morphology.
Sorting efficiency in mechanical sorting of construction and demolition waste
Authors: Hyvärinen Marko , Ronkanen Mikko , Kärki Timo
Published: April 2020

The requirements for the recycling of construction and demolition waste are tightening, and companies in the waste business have improved their performance to comply with new legislation. Construction and demolition waste includes various recyclable materials, such as metals, plastics and wood. However, effective material recovery requires functional and reliable technology for sorting in order to separate waste fractions into useful secondary materials or applications. This paper concerns the mechanical sorting efficiency of construction and demolition waste with a commercial mechanical sorting equipment consisting of a roller screening and an air separation unit. Sorting ability is studied with pre-sorted and crushed test material. Sieve analysis of pre-sorted test material is used to define particle size distribution before sorting. The quality criteria of construction and demolition waste vary greatly, depending on a number of factors which pose a challenge to the operation of the sorting system. The studied sorting equipment was found to be reliable for producing nine different fractions from pre-sorted and crushed material mixtures. The requirements for the purity level of the fractions and the profitability of utilization define the number of fractions to be sorted cost-efficiently. Typically, a compromise between cost and purity level has to be found.
Characterization of pond ash-bentonite mixes as landfill liner material
Authors: Rout Suryaleen , Singh Suresh Prasad
Published: April 2020

Characterization of pond ash-bentonite mixes is made to assess their suitability as liner material for waste disposal facilities by examining the relevant index and engineering properties. Further, a comparative assessment is made between sand-bentonite and pond ash-bentonite mixes for the range of bentonite content varying from 0 to 30% by weight at an interval of 5% to ensure an effective substitution of sand with pond ash. Addition of bentonite to sand or pond ash significantly influences the plasticity, strength and permeability properties. Besides, the shape parameters of the coarser fraction and morphology of compacted mixes also influence the engineering properties. A multiple linear regression equation is suggested to predict the hydraulic conductivity of these mixes by considering the basic material properties such as liquid limit, plasticity index and void ratio as an input variable with a correlation coefficient of 0.92 between the measured and predicted hydraulic conductivity values. At comparable conditions, compacted pond ash-bentonite mixes exhibit higher strength but also higher permeability than sand-bentonite mixes. Pond ash-bentonite and sand-bentonite mixes met the liner requirements when compacted with modified Proctor compaction effort at a minimum bentonite content of 20% and 15%, respectively.
Helping Teens Overcome Anxiety Episodes in Project Work: The Power of Reframing
Authors: Orson Carolyn N. , Larson Reed W.
Published: April 2020

Overwhelming challenges in youth program projects (e.g., arts, leadership, science, technology, engineering, and mathematics [STEM]) can create intense anxiety for adolescents that disrupts engagement in their work. This study examines how experienced program leaders respond to these episodes to help youth overcome anxiety. We conducted semi-structured interviews with 27 veteran leaders from high-quality youth programs about their experiences with these situations. Programs primarily served Latinx, African American, and European American youth (ages 11–18). We utilized grounded theory analysis to examine leaders’ descriptions of the situations, their strategies, and the goals of those strategies. Leaders’ most frequent response was reframing—providing youth new cognitive frames to understand anxiety-eliciting situations, reduce anxiety, and restore motivation. We identified three types of reframing strategies. First, reframing youth’s understanding of their abilities entailed providing youth new perspectives for enhancing their conceptions of their competencies in the work. Second, reframing youth’s understanding of challenge involved suggesting new frameworks for youth to assess and control work challenges. Third, reframing emotion involved helping youth understand anxiety as normal and as a tool for problem-solving. The findings also suggest these strategies help youth learn skills for managing situations that create anxiety in future work.
The Effects of State and Local Economic Incentives on Business Start-Ups in the United States: County-Level Evidence
Authors: Partridge Mark , Schreiner Sydney , Tsvetkova Alexandra , Patrick Carlianne Elizabeth
Published: April 2020

Even as economic incentives are increasingly used by policy makers to spur state and local economic development, their use is controversial among the public and academics. The authors examine whether state and local incentives lead to higher rates of business start-ups in metropolitan counties. Existing research indicates that start-ups are important for supporting (net) job creation, long-term growth, innovation, and development. The authors find that incentives have a statistically significant, negative relationship with start-up rates in total and for some industries including export-based and others that often receive incentives. The findings support critics who contend that incentives crowd out other economic activity, potentially reducing long-term growth. The authors also find that greater intersectoral job flows are positively linked to total start-ups, consistent with claims of those who advocate for policies that enhance labor market flexibility through reducing barriers to job mobility.
Capitalism, Critique and Social Freedom: An Interview With Axel Honneth on Freedom’s Right
Authors: Curty Gaël
Published: April 2020

Axel Honneth is internationally renowned as one of the leading critical theorists of our time and is highly regarded for his development of the theory of recognition. In these two interviews, Axel Honneth sets out the formal modalities, normative contents, and normative justifications of the critique of capitalism that he has developed in his book Freedom’s Right. After briefly defining his conception of capitalist market society, he presents his method of normative reconstruction and the formal modalities of his critique of capitalism. He then sets out his critical diagnosis and solutions to the normative misdevelopments produced by capitalism and concludes, finally, with a discussion and justification of the normative ideal of social freedom at the core of his theory.
Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo
Authors: Jagadish Nirmala , Devi Sonika , Gupta Namita , Suri Vitusha , Suri Anil
Published: April 2020

Triple-negative breast cancers are the most aggressive subtypes with poor prognosis due to lack of targeted cancer therapy. Recently, we reported an association of A-kinase anchor protein 4 expression with various clinico-pathological parameters of breast cancer patients. In this context, we examined the effect of knockdown of A-kinase anchor protein 4 on cell cycle, apoptosis, cellular proliferation, colony formation, migration, and invasion in triple-negative breast cancer cells. We also examined the synergistic cytotoxic effect of paclitaxel on A-kinase anchor protein 4 downregulated triple-negative breast cancer cells. Knockdown of A-kinase anchor protein 4 resulted in significant reduction in cellular growth and migratory abilities. Interestingly, we also observed enhanced cell death in A-kinase anchor protein 4 downregulated cells treated with paclitaxel. Knockdown of A-kinase anchor protein 4 in cell cycle resulted in G0/G1 phase arrest. Knockdown of A-kinase anchor protein 4 also led to increased reactive oxygen species generation as a result of upregulation of NOXA and CHOP. In addition, levels of cyclins, cyclin-dependent kinases, anti-apoptotic molecules, and mesenchymal markers were reduced in A-kinase anchor protein 4 downregulated cells. Moreover, downregulation of A-kinase anchor protein 4 also caused tumor growth reduction in in vivo studies. These data together suggest that A-kinase anchor protein 4 downregulation inhibits various malignant properties and enhances the cytotoxic effect of paclitaxel, and this combinatorial approach could be useful for triple-negative breast cancer treatment.
Transitional Phase in Agriculture Towards Modernisation: A Perspective on Paddy Cultivation
Authors: Halder Soumik , Mukhopadhyay Sayani
Published: April 2020

The contribution of agriculture in GDP of India is dramatically reduced though a large number of people are associated with this occupation. To increase the GDP contribution of agriculture and to raise the income of farmers, the use of modern machineries is an utmost necessity. The aim of this study is to identify the status of mechanisation of agriculture at Rampurhat: I block in Birbhum district to assess the impact of modern machineries on farming and livelihood status of farmers and agricultural labourers. To reduce the cost of agricultural production, farmers resort to farm mechanisation without changing the overall cultivation practice in this area. This region is in a transitional stage of modernisation of agriculture. This research also investigates and discusses the problems associated with the prospects of mechanisation of agriculture in this area.
What Nonresident Mothers and Fathers Have to Say About a Mother-Only Coparenting Intervention: A Qualitative Assessment of Understanding DadsTM
Authors: Pearson Jessica , Henson Abigail , Fagan Jay
Published: April 2020

Coparenting between mothers and nonresident fathers is a consistent predictor of positive father involvement and is shown to have a direct positive impact on children’s behavioral outcomes. While many fatherhood programs attempt to improve coparenting relationships using father-only interventions, the information on their effectiveness is mixed. Couple interventions may be more effective than father-only approaches but are very hard to achieve with nonresident parents. Engaging mothers may be more practical and beneficial, although there is very little literature on the impact of mother-only interventions on coparenting relationships. The current study begins to address that gap. It presents qualitative reactions by mothers and fathers to a mother-only coparenting intervention and finds that a mother-only approach can achieve some important goals such as improved communication, reduced conflict, and mother’s understanding of the father’s point of view. Fathers whose parenting partners participated in the mother-only group agreed with mothers’ assessments and also reported less undermining.
Factors Predicting the Scientific Wealth of Nations
Authors: Allik Jüri , Lauk Kalmer , Realo Anu
Published: April 2020

It has been repeatedly demonstrated that economic affluence is one of the main predictors of the scientific wealth of nations. Yet, the link is not as straightforward as is often presented. First, only a limited set of relatively affluent countries is usually studied. Second, there are differences between equally rich countries in their scientific success. The main aim of the present study is to find out which factors can enhance or suppress the effect of the economic wealth of countries on their scientific success, as measured by the High Quality Science Index ( HQSI). The HQSI is a composite indicator of scientific wealth, which in equal parts considers the mean citation rate per paper and the percentage of papers that have reached the top 1% of citations in the Essential Science Indicators ( ESI; Clarivate Analytics) database during the 11-year period from 2008 to 2018. Our results show that a high position in the ranking of countries on the HQSI can be achieved not only by increasing the number of high-quality papers but also by reducing the number of papers that are able to pass ESI thresholds but are of lower quality. The HQSI was positively and significantly correlated with the countries’ economic indicators (as measured by gross national income and Research and Development expenditure as a percentage from GDP), but these correlations became insignificant when other societal factors were controlled for. Overall, our findings indicate that it is small and well-governed countries with a long-standing democratic past that seem to be more efficient in translating economic wealth into high-quality science.
Protecting Participants in Genomic Research: Understanding the “Web of Protections” Afforded by Federal and State Law
Authors: Wolf Leslie E. , Hammack Catherine M. , Brown Erin Fuse , Brelsford Kathleen M. , Beskow Laura M.
Published: April 2020

Researchers now commonly collect biospecimens for genomic analysis together with information from mobile devices and electronic health records. This rich combination of data creates new opportunities for understanding and addressing important health issues, but also intensifies challenges to privacy and confidentiality. Here, we elucidate the “web” of legal protections for precision medicine research by integrating findings from qualitative interviews with structured legal research and applying them to realistic research scenarios involving various privacy threats.
Data Sharing in the Context of Health-Related Citizen Science
Authors: Majumder Mary A. , McGuire Amy L.
Published: April 2020

As citizen science expands, questions arise regarding the applicability of norms and policies created in the context of conventional science. This article focuses on data sharing in the conduct of health-related citizen science, asking whether citizen scientists have obligations to share data and publish findings on par with the obligations of professional scientists. We conclude that there are good reasons for supporting citizen scientists in sharing data and publishing findings, and we applaud recent efforts to facilitate data sharing. At the same time, we believe it is problematic to treat data sharing and publication as ethical requirements for citizen scientists, especially where there is the potential for burden and harm without compensating benefit.
Researching With Our Hair on Fire: Three Frameworks for Rethinking News in a Postnormative World
Authors: Parks Perry
Published: April 2020

This article urges a jolt in journalism theory commensurate with the urgent state of planetary affairs—including catastrophic climate change and spreading authoritarianism—that journalism’s weaknesses have helped to precipitate and that its strengths might help to contain. The article explores three conceptual frameworks offering alternative approaches to conceiving news that might disrupt the stasis of our polarized societies: “existential journalism,” or a call to radical independence; Buddhist news values, based on ontological and ethical commitments favoring interdependence and compassion; and nonrepresentational news, inspired by an epistemologically expansive style of social research privileging affect, immanence, and wide-eyed attention. Attending to journalisms of engagement, compassion, and everyday joys might disrupt the heuristic partisanship and protective avoidance that characterize citizens’ contemporary relations with news, opening possibilities for more generative politics.
Noteworthy Cardiac Literature 2019: Cerebral Protection, Zone 2 Arch, Intravascular Ultrasonography in Dissection, Heart Allocation, and Mitral Durability
Authors: Ghincea Christian V. , Reece T. Brett , Aftab Muhammad , Cleveland Joseph C. , Pal Jay D.
Published: April 2020

The year of 2019 continues to have notable literature advancing the practice of cardiac surgery. In this article, topics of discussion will include the evolution of cerebral protection, the advancement of arch surgical techniques, the heart transplant allocation system, and mitral repair approach and durability.
Decidual Granulomata of Unclear Significance
Authors: Raj Thomas , Pierce Brian , Brady Robert
Published: April 2020

Granulomatous inflammation is a histologic finding with a relatively wide variety of causes. In general, considerations include infectious etiologies, autoimmune conditions, or foreign body reactions. Granulomatous inflammation is uncommonly seen in the placenta. We present a unique case of a young woman with preterm labor and rupture of membranes whose placenta demonstrated perivascular decidual granulomata in the membranes and the basal plate.
Tracing Ideas From Langley (1999): Exemplars, Adaptations, Considerations, and Overlooked
Authors: Lerman Michael P. , Mmbaga Nick , Smith Anne
Published: April 2020

Well-accepted methodological practices require thoughtful and appropriate use to avoid becoming mindlessly applied and distorted. We review how ideas from Langley’s (1999) process data analysis article have been used in practice. By closely analyzing 176 empirical articles in management and organization journals from 1999 to 2019, we highlight how Langley’s ideas have been applied in exemplary ways and adapted through bricolage (a central concept in qualitative methods). In many instances, we found that Langley’s ideas have been given a cursory nod or have even been distorted (what we label as considerations); thus, we recommend how to avoid replicating these applications. We discuss process data analysis tools from Langley’s article that have been underused (labeled overlooked) but that may be valuable in future process studies. Through our deep reading and review, we highlight how using Langley’s ideas can enhance the transparency and trustworthiness of a qualitative process study and mitigate her ideas’ movement toward a mindless template application.
Exercise-Induced Premature Ventricular Contractions Are Associated With Myocardial Ischemia Among Asymptomatic Adult Male Firefighters: Implications for Enhanced Risk Stratification
Authors: Dzikowicz Dillon J. , Carey Mary G.
Published: April 2020

Background:

Exercise-induced premature ventricular contractions (EI-PVCs) are associated with an increased risk of cardiovascular disease among asymptomatic adult males, but the underlying mechanisms remain understudied. Myocardial ischemia due to cardiovascular disease reduces coronary blood flow, may impair exercise performance, and initiates EI-PVCs; thus, EI-PVCs may be an early indicator of cardiovascular disease.

Objective:

The objective of this study was to determine whether EI-PVCs are associated with myocardial ischemia and reduced exercise performance among asymptomatic adult firefighters.

Methods:

Asymptomatic adult firefighters free of known cardiovascular disease underwent exercise treadmill testing. A 12-lead electrocardiography was placed on participants for 24 hr afterward to measure EI-PVCs in recovery. Univariate and multivariate binary logistic regression models were used to assess the odds of myocardial ischemia. Sensitivity and specificity analyses were conducted. Statistical significance was set at p < .05.

Results:

Participants comprised 86 asymptomatic adult males. The prevalence of myocardial ischemia was 30.8%. A single EI-PVC was associated with myocardial ischemia (χ2 = 8.98; p = .003). EI-PVC remained a significant predictor despite adjustment for other cardiovascular risks (odds ratio = 4.281, p = .038). Although not statistically significant, the EI-PVC group achieved lower total exercise time (11.4 ± 2.9 vs. 12.4 ± 3.0 min, p = .13), lower metabolic equivalent of tasks (METs; 11.6 ± 2.6 vs. 12.8 ± 2.3 METs, p = .06), and a lower maximum exercise speed (4.4 ± 0.7 vs. 4.7 ± 0.8 miles/hr, p = .07).

Discussion:

EI-PVCs are associated with myocardial ischemia among asymptomatic male firefighters, providing additional evidence of the association between EI-PVCs and myocardial ischemia and suggesting EI-PVCs as an early indicator of cardiovascular disease.
Window to the circulatory system: Ocular manifestations of cardiovascular diseases
Authors: Singh Rohan Bir , Saini Chhavi , Shergill Sukhman , Agarwal Aniruddha
Published: April 2020

The changes in the cardiovascular system are associated with ocular manifestations, often as a consequence of pathological alteration in the ocular vasculature. The ease of visualization of these retinal changes makes the eye a window to the cardiovascular system. Certain congenital cardiac defects lead to changes in the retinal vascularity due to increased tortuosity and dilatation. In adults, the arterial dissection of internal carotid and vertebral arteries present as amaurosis fugax with or without oculo-sympathetic palsy. The patients with untreated infective endocarditis present with Roth spots, retinitis, embolic retinopathy, or sub-retinal abscesses. Hypoperfusive, hypertensive, or “mixed” retinopathy is a hallmark sign in patients of untreated infective endocarditis. Giant cell arteritis can present with ischemic ocular symptoms that may precipitate in irreversible vision loss. Systemic vascular manifestations such as coronary artery disease may manifest in a wide range of symptoms from amaurosis fugax to vision loss depending upon the size and location of retinal emboli. Rare cardio-oncological pathologies such as myxomas result in vision loss secondary to central retinal artery occlusion. A high clinical suspicion in patients with history of cardiovascular diseases can help in early diagnosis and management of impending, adverse cardiovascular and cerebrovascular events. In this review, we comprehensively discuss the spectrum of cardiac and vascular diseases with ocular manifestations as well as highlight the typical ocular presentations associated with these pathologies.
Oculocerebrorenal syndrome of Lowe: Survey of ophthalmic presentations and management
Authors: Ma Xiaowan , Ning Ke , Jabbehdari Sayena , Prosseda Philipp P. , Hu Yang , Shue Ann , Lambert Scott R. , Sun Yang
Published: April 2020

Background

Lowe syndrome is a rare X-linked disease that is characterized by renal dysfunction, developmental delays, congenital cataracts and glaucoma. Mutations in the oculocerebral renal syndrome of Lowe ( OCRL) gene are found in Lowe syndrome patients. Although loss of vision is a major concern for families and physicians who take care of Lowe syndrome children, definitive cause of visual loss is still unclear. Children usually present with bilateral dense cataracts at birth and glaucoma, which occurs in more than half of cases, either concurrently or following cataract surgery.

Materials and methods

A retrospective review was conducted on the prevalence and characteristics of ocular findings among families of patients with Lowe syndrome with 137 uniquely affected individuals.

Results

Of 137 patients, all had bilateral congenital cataracts. Nystagmus was reported in 69.3% of cases, glaucoma in 54.7%, strabismus in 35.0%, and corneal scar in 18.2% of patients. Glaucoma was reported as the most common cause of blindness (46%) followed by corneal scars (41%). Glaucoma occurred in 54.7% of patients and affected both eyes in the majority of cases. Of these patients, 55% underwent surgery for glaucoma, while the remaining patients used medications to control their eye pressure. Timolol and latanoprost were the most commonly used medications. Although trabeculectomy and goniotomy are commonly used for pressure management, aqueous tube shunts had the best outcomes.

Conclusion

Ocular manifestations in individuals with Lowe syndrome and carriers with OCRL mutation are reported which may help familiarize clinicians with the ocular manifestations and management of a rare and complex syndrome.