bluuebunny/crossref_metadata_2025 huggingface dataset:
On Tides and Exoplanets
Authors: Ferraz-Mello S.
Published: May 2022

This paper reviews the basic equations used in the study of the tidal variations of the rotational and orbital elements of a system formed by one star and one close-in planet as given by the creep tide theory and Darwin’s constant time lag (CTL) theory. At the end, it reviews and discusses the determinations of the relaxation factors (and time lags) in the case of host stars and hot Jupiters based on actual observations of orbital decay, stellar rotation and age, etc. It also includes a recollection of the basic facts concerning the variations of the rotation of host stars due to the leakage of angular momentum associated with stellar winds.
Evolution and stability of Laplace-like resonances under tidal dissipation
Authors: Celletti A. , Karampotsiou E. , Lhotka C. , Pucacco G. , Volpi M.
Published: May 2022

The Laplace resonance is a configuration that involves the commensurability between the mean motions of three small bodies revolving around a massive central one. This resonance was first observed in the case of the three inner Galilean satellites, Io, Europa, and Ganymede. In this work the Laplace resonance is generalised by considering a system of three satellites orbiting a planet that are involved in mean motion resonances. These Laplace-like resonances are classified in three categories: first-order (2:1&2:1, 3:2&3:2, 2:1&3:2), second-order (3:1&3:1) and mixed-order resonances (2:1&3:1). In order to study the dynamics of the system we implement a model that includes the gravitational interaction with the central body, the mutual gravitational interactions of the satellites, the effects due to the oblateness of the central body and the secular interaction of a fourth satellite and a distant star. Along with these contributions we include the tidal interaction between the central body and the innermost satellite. We study the survival of the Laplace-like resonances and the evolution of the orbital elements of the satellites under the tidal effects. Moreover, we study the possibility of capture into resonance of the fourth satellite.
Cascade disruption in Rampo family
Authors: Vasileva Mariia , Kuznetsov Eduard , Rosaev Alexey , Plávalová Eva
Published: May 2022

We have found three new members of the Rampo asteroids family: 2009HD95, 2010VO19, 2013JF69. We estimated the Yarkovsky semimajor axis drift rate. Based on the simulation results, estimates of the asteroid pairs’ age included in the family are obtained. In the scenario of the cascade disruption of the parent body of the asteroid (10321) Rampo, one can note the concentration of estimates of the pairs’ age to values of 900, 750, 500, and 250 kyr.
Neonatal Outcome in Twin-to-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery
Authors: Lopriore Elina A. , Slaghekke Femke , Verweij E. Joanne , Haak Monique C. , Middeldorp Annemieke J. M. , Lopriore Enrico
Published: May 2022

The aim of this study was to describe the neonatal management and outcome in monochorionic twins with twin-to-twin transfusion syndrome (TTTS) not treated with fetoscopic laser surgery. All consecutive live-born neonates with TTTS managed at our center between 2002 and 2021 were included in this retrospective study. Neonatal outcome was assessed in 44 twin pairs with TTTS not treated with laser (nonlaser group) compared to a control group of 88 twin pairs with TTTS successfully treated with laser (laser group), matched for gestational age at birth. Primary outcome was adverse neonatal outcome, a composite outcome including neonatal mortality or severe neonatal morbidity. The incidence of adverse neonatal outcome in the nonlaser group and laser group was 30% (26/88) and 11% (19/176), respectively (relative risk = 3.46, 95% CI [1.79, 6.71]). In the nonlaser group, 11% had necrotizing enterocolitis (vs. 2% in the laser group) and 24% had hypotension (vs. 10% in the laser group). Recipients in the nonlaser group had, compared to recipients in the laser group, significantly more severe cerebral injury (18% vs. 5%) and more polycythemia at birth (21% vs. 1%). Donors in the nonlaser group had, compared to donors in the laser group, more severe growth restriction (71% vs 42%), renal failure (11% vs 1%), and anemia at birth (25% vs. 7%). Thus, the risk for neonatal mortality and/or severe morbidity is three-fold higher in TTTS not treated with laser than in TTTS treated with laser, which highlights the fact that these neonates with TTTS are very sick at birth, requiring accurate and prompt intensive treatment.
Seismic Detection of Euroquakes Originating From Europa's Silicate Interior
Authors: Marusiak A. G. , Panning M. P. , Vance S. D. , Nunn C. , Stähler S. C. , Tharimena S.
Published: May 2022

Detecting a seismic event from Europa's silicate interior would provide information about the geologic and tectonic setting of the moon's rocky interior. However, the subsurface ocean will attenuate the signal, possibly preventing the waveforms from being detected by a surface seismometer. Here, we investigate the minimum magnitude of a detectable event originating from Europa's silicate interior. We analyze likely signal‐to‐noise ratios and compare the predicted signal strengths to current instrument sensitivities. We show that a magnitude Mw ≥ 3.5 would be sufficient to overcome the predicted background noise when the ice shell is 5 km thick. However, a minimum magnitude of Mw ≥ 5.5 would be required for current instrumentation to be able detect the event for any ice shell thickness, at any distance. A thinner ice shell transmits greater ground acceleration amplitudes than a thicker ice shell, which might allow for Mw ≥ 4.5 to be detectable.
An Automated Method for Mapping Independent Spatial b Values
Authors: Godano C. , Convertito V. , Pino N. A. , Tramelli A.
Published: May 2022

We present an automated method for mapping the b values. The algorithm is very simple and presents three advantages: (a) it does not requires any tuning of the parameters like, for instance, a fixed cell size or a maximum radius of the cell; (b) it implies a more appropriate use of the catalog, by using almost all the events in the catalog used (with a tolerance of 1%) with no overlap; (c) it implies the full independence of the b values, thus allowing the statistical comparison of the results using standard tests. Although the resulting b values are comparable with those obtained by applying the other methods of common use in seismology, these latter (a) leave out many earthquakes from the analysis, with loose of useful information, (b) produce diffuse cells overlapping aiming at reaching many cells of the grid in order to get the correct number of events in each cell, and (c) results in correlated b values, which do not allow the test of significance for the differences in the b values. Finally, due to the independence from any ad hoc a‐priori choice, our method is suitable for automatic and operator‐free procedures.
Characteristics of VOC Composition at Urban and Suburban Sites of New Delhi, India in Winter
Authors: Tripathi Nidhi , Sahu L. K. , Wang Liwei , Vats Pawan , Soni Meghna , Kumar Purushottam , Satish R. V. , Bhattu Deepika , Sahu Ravi , Patel Kashyap , Rai Pragati , Kumar Varun , Rastogi Neeraj , Ojha Narendra , Tiwari Shashi , Ganguly Dilip , Slowik Jay , Prévôt André S. H. , Tripathi Sachchida N.
Published: May 2022

Simultaneous measurements of volatile organic compounds (VOCs) using two PTR‐TOF‐MS instruments were conducted at urban and suburban sites of New Delhi during the winter of 2018. The time series of VOC mixing ratios show substantial variations mainly influenced by local emissions and meteorological conditions. Mixing ratios of methanol (∼28 ppbv), acetaldehyde (7.7 ppbv), acetone (10.6 ppbv), isoprene (2.8 ppbv) and monoterpenes (0.84 ppbv) at the suburban site were higher than those at the urban site, while levels of aromatic VOCs were almost similar. The strong nighttime correlations of isoprene and monoterpenes with CO and benzene at the urban site indicate their predominant anthropogenic origin. Higher emission ratios of ∆VOCs/∆CO and ∆VOCs/∆benzene than those reported for vehicular exhaust suggest the contributions of other sources. In addition to vehicular emissions, episodes of biomass burning, industrial plumes and aged air strongly influenced the levels of VOCs at the suburban site. Despite the predominant primary anthropogenic emissions, the higher daytime enhancements of OVOCs/CO ratios indicate additional contributions of OVOCs from secondary/biogenic sources. The secondary formation of OVOCs in moderately aged air masses was noticeable at the suburban site. Using the source‐tracer‐ratio method, the estimated biogenic contributions of isoprene (71%) and acetone (65%) during daytime at the suburban site were significantly higher than those for the urban site. The photochemical box model simulations suggest that daytime ozone formation was under the VOC‐limited regime. The present study highlights the impact of different emission sources, photochemical processes and meteorological conditions on the composition and concentration of VOCs in the Delhi region.
Correlation of Venusian Mesoscale Cloud Morphology Between Images Acquired at Various Wavelengths
Authors: Narita M. , Imamura T. , Lee Y. J. , Watanabe S. , Yamazaki A. , Satoh T. , Taguchi M. , Sato T. M. , Fukuhara T. , Yamada M. , Kouyama T. , Iwagami N.
Published: May 2022

The differences and similarities in morphologies acquired across various wavelengths in simultaneously obtained Venus' dayside images may provide clues on cloud/atmospheric physics and chemistry. Here, we focus on spatial scales smaller than ∼600 km, where cell‐like or streaky features seem to dominate in ultraviolet images. Using images acquired at ultraviolet wavelengths of 283 nm, 365 nm, and infrared wavelengths of 0.90, 2.02, and 10 μm by the Venus orbiter Akatsuki, correlation coefficient maps between pairs of wavelengths, such as 2.02 μm/10 μm, 2.02 μm/283 nm, 2.02 μm/365 nm, 283 nm/365 nm, and 0.90 μm/2.02 μm were created. Our results show a clear negative correlation between images obtained at 2.02 μm (CO2 absorption) and 10 μm (cloud top temperature), meaning that elevated clouds are cooled by adiabatic expansion or the ambient air. A clear negative correlation was found between 2.02 μm and 283 nm (SO2 absorption), suggesting that SO2 is transported to the cloud top region during cloud ascent. We observed a clear positive correlation between images obtained at 283 and 365 nm (unknown absorber), implying a close relationship between the unknown absorber and SO2 or a non‐negligible contribution of the unknown absorber at 283 nm. We found a low correlation between images obtained at 0.90 μm (middle/lower cloud) and 2.02 μm, suggesting a weak vertical coupling in the clouds.
Association between built environments and weight status: evidence from longitudinal data of 9589 Australian children
Authors: Putra I Gusti Ngurah Edi , Astell-Burt Thomas , Feng Xiaoqi
Published: May 2022

Background

No studies appear to examine potential associations between changes in built environments across childhood and the developmental trajectories of child weight status.

Objective

Examine the developmental trajectories of child weight status with respect to changes in childhood exposure to the built environments.

Methods

This study used data of 9589 children with biennial follow-up (2004–2016), retrieved from the Longitudinal Study of Australian Children. Changes in objectively-measured child weight status (i.e., body mass index-BMI, waist circumference) were investigated in relation to changes in seven built environments (i.e., neighbourhood safety; green space quality; footpaths and street conditions; public transport; shopping facilities; basic services; and local traffic) subjectively reported by caregivers. Group-based discrete trajectory mixture models were used to classify children according to their developmental trajectories of built environments and weight status. Multilevel multinomial logistic regression was employed to examine associations between built environments and child weight status adjusted for confounding.

Results

Two, four, and six trajectory groups were developed for built environment variables. Three groups namely “moderate”, “high”, and “extreme increase” were generated for each BMI and waist circumference. Findings from multilevel analyses indicated that growing up in neighbourhoods that are considered highly safe, with better quality of green space nearby, and in areas with low local traffic over time are protective against unhealthy weight increase in childhood. Meanwhile, living with better access to shopping facilities and basic services was associated with an unhealthy increase in BMI and/or waist circumference. No clear associations appeared between the quality of footpath and street conditions, access to public transport, and child weight status.

Conclusions

Built environments might act either as a risk or protective factor of an unhealthy increase in child weight status. Enabling health-promoting neighbourhoods (i.e., highly safe, quality green space nearby, low local traffic) is important to support a healthy weight trajectory across childhood.
Intrinsic superflat bands in general twisted bilayer systems
Authors: Wang Hongfei , Ma Shaojie , Zhang Shuang , Lei Dangyuan
Published: May 2022

Twisted bilayer systems with discrete magic angles, such as twisted bilayer graphene featuring moiré superlattices, provide a versatile platform for exploring novel physical properties. Here, we discover a class of superflat bands in general twisted bilayer systems beyond the low-energy physics of magic-angle twisted counterparts. By considering continuous lattice dislocation, we obtain intrinsic localized states, which are spectrally isolated at lowest and highest energies and spatially centered around the AA stacked region, governed by the macroscopic effective energy potential well. Such localized states exhibit negligible inter-cell coupling and support the formation of superflat bands in a wide and continuous parameter space, which can be mimicked using a twisted bilayer nanophotonic system. Our finding suggests that general twisted bilayer systems can realize continuously tunable superflat bands and the corresponding localized states for various photonic, phononic, and mechanical waves.
Advanced liquid crystal devices for augmented reality and virtual reality displays: principles and applications
Authors: Yin Kun , Hsiang En-Lin , Zou Junyu , Li Yannanqi , Yang Zhiyong , Yang Qian , Lai Po-Cheng , Lin Chih-Lung , Wu Shin-Tson
Published: May 2022

Liquid crystal displays (LCDs) and photonic devices play a pivotal role to augmented reality (AR) and virtual reality (VR). The recently emerging high-dynamic-range (HDR) mini-LED backlit LCDs significantly boost the image quality and brightness and reduce the power consumption for VR displays. Such a light engine is particularly attractive for compensating the optical loss of pancake structure to achieve compact and lightweight VR headsets. On the other hand, high-resolution-density, and high-brightness liquid-crystal-on-silicon (LCoS) is a promising image source for the see-through AR displays, especially under high ambient lighting conditions. Meanwhile, the high-speed LCoS spatial light modulators open a new door for holographic displays and focal surface displays. Finally, the ultrathin planar diffractive LC optical elements, such as geometric phase LC grating and lens, have found useful applications in AR and VR for enhancing resolution, widening field-of-view, suppressing chromatic aberrations, creating multiplanes to overcome the vergence-accommodation conflict, and dynamic pupil steering to achieve gaze-matched Maxwellian displays, just to name a few. The operation principles, potential applications, and future challenges of these advanced LC devices will be discussed.
Graphene-driving novel strain relaxation towards AlN film and DUV photoelectronic devices
Authors: Nguyen Hieu. P. T.
Published: May 2022

Graphene-driving strain-pre-store engineering enables the epitaxy of strain-free AlN film with low dislocation density for DUV-LED and the unique mechanism of strain-relaxation in QvdW epitaxy was demystified.
Structural variants shape the genomic landscape and clinical outcome of multiple myeloma
Authors: Ashby Cody , Boyle Eileen M. , Bauer Michael A. , Mikulasova Aneta , Wardell Christopher P. , Williams Louis , Siegel Ariel , Blaney Patrick , Braunstein Marc , Kaminetsky David , Keats Jonathan , Maura Francesco , Landgren Ola , Walker Brian A. , Davies Faith E. , Morgan Gareth J.
Published: May 2022

Deciphering genomic architecture is key to identifying novel disease drivers and understanding the mechanisms underlying myeloma initiation and progression. In this work, using the CoMMpass dataset, we show that structural variants (SV) occur in a nonrandom fashion throughout the genome with an increased frequency in the t(4;14), RB1, or TP53 mutated cases and reduced frequency in t(11;14) cases. By mapping sites of chromosomal rearrangements to topologically associated domains and identifying significantly upregulated genes by RNAseq we identify both predicted and novel putative driver genes. These data highlight the heterogeneity of transcriptional dysregulation occurring as a consequence of both the canonical and novel structural variants. Further, it shows that the complex rearrangements chromoplexy, chromothripsis and templated insertions are common in MM with each variant having its own distinct frequency and impact on clinical outcome. Chromothripsis is associated with a significant independent negative impact on clinical outcome in newly diagnosed cases consistent with its use alongside other clinical and genetic risk factors to identify prognosis.
High-risk disease in newly diagnosed multiple myeloma: beyond the R-ISS and IMWG definitions
Authors: Hagen Patrick , Zhang Jiwang , Barton Kevin
Published: May 2022

Multiple myeloma (MM) is an acquired malignant plasma cell disorder that develops late in life. Although progression free and overall survival has improved across all age, race, and ethnic groups, a subset of patients have suboptimal outcomes and are labeled as having high risk disease. A uniform approach to risk in NDMM remains elusive despite several validated risk stratification systems in clinical use. While we attempt to capture risk at diagnosis, the reality is that many important prognostic characteristics remain ill-defined as some patients relapse early who were defined as low risk based on their genomic profile at diagnosis. It is critical to establish a definition of high risk disease in order to move towards risk-adapted treatment approaches. Defining risk at diagnosis is important to both effectively design future clinical trials and guide which clinical data is needed in routine practice. The goal of this review paper is to summarize and compare the various established risk stratification systems, go beyond the R-ISS and international myeloma working group risk stratifications to evaluate specific molecular and cytogenetic abnormalities and how they impact prognosis independently. In addition, we explore the wealth of new genomic information from recent whole genome/exome sequencing as well as gene expression data and review known clinical factors affecting outcome such as disease burden and early relapse as well as patient related factors such as race. Finally, we provide an outlook on developing a new high risk model system and how we might make sense of co-occurrences, oncogenic dependencies, and mutually exclusive mutations.
Efficacy of FOLFIRI plus cetuximab vs FOLFIRI plus bevacizumab in 1st-line treatment of older patients with RAS wild-type metastatic colorectal cancer: an analysis of the randomised trial FIRE-3
Authors: Fischer Laura E. , Stintzing Sebastian , von Weikersthal Ludwig Fischer , Modest Dominik P. , Decker Thomas , Kiani Alexander , Kaiser Florian , Al-Batran Salah-Eddin , Heintges Tobias , Lerchenmüller Christian , Kahl Christoph , Seipelt Gernot , Kullmann Frank , Stauch Martina , Scheithauer Werner , Giessen-Jung Clemens , Uhlig Jens , Peuser Bettina , Denzlinger Claudio , Stahler Arndt , Weiss Lena , Heinrich Kathrin , Held Swantje , Jung Andreas , Kirchner Thomas , Heinemann Volker
Published: May 2022

Background

The evidence on the efficacy of anticancer therapy is limited in older patients with metastatic colorectal cancer (mCRC). This retrospective analysis of phase III FIRE-3 trial assesses the efficacy of FOLFIRI plus either cetuximab or bevacizumab according to the patients’ age and sidedness of primary tumour.

Methods

The study endpoints overall response rate (ORR), progression-free survival (PFS) and overall survival (OS) were compared between younger (<65 years) and older (≥65 years) patients, followed by stratification according to primary tumour sidedness. ORR was compared using Fisher´s exact test, OS and PFS were estimated by the Kaplan–Meier method and compared using the log-rank test. Univariate Cox regression analyses assessed hazard ratios and 95% confidence intervals for OS and PFS.

Results

Overall, older patients with RAS WT tumours had a significantly shorter OS when compared to younger patients (25.9 months vs 29.3 months, HR 1.29; P = 0.02). Also the proportion of right-sided tumours was significantly greater in older patients (27.1% vs 17.9%; P = 0.029). Secondary resection rates were numerically higher in younger patients (25.4% vs. 17.6%, P = 0.068) than in older patients. This was primarily seen in the Cetuximab arm, where older patients underwent less likely resection (13.1% vs. 26%; P = 0.02). Older patients with left-sided tumours showed only a trend towards greater efficacy of cetuximab (HR 0.86; P = 0.38). In patients with right-sided primary tumours, older patients did not appear to benefit from cetuximab in contrast to younger patients (≥65 years: 16.6 months vs 23.6 months, HR 1.1; P = 0.87; <65 years: 21.9 months vs 16.4 months HR 1.5; P = 0.31).

Conclusions

In FIRE-3, OS was generally shorter in older patients in comparison to younger patients. This could be explained by the overrepresentation of right-sided tumours and a lower secondary resection rate in older patients. The efficacy of targeted therapy was dependent on tumour sidedness in older patients with RAS WT mCRC.

Clinical trial

FIRE-3 (NCT00433927).
Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury
Authors: Qin Qiyu , Yu Naiji , Gu Yuxiang , Ke Weishaer , Zhang Qi , Liu Xin , Wang Kaijun , Chen Min
Published: May 2022

Progressive retinal ganglion cells (RGCs) death that triggered by retinal ischemia reperfusion (IR), leads to irreversible visual impairment and blindness, but our knowledge of post-IR neuronal death and related mechanisms is limited. In this study, we first demonstrated that apart from necroptosis, which occurs before apoptosis, ferroptosis, which is characterized by iron deposition and lipid peroxidation, is involved in the whole course of retinal IR in mice. Correspondingly, all three types of RGCs death were found in retina samples from human glaucoma donors. Further, inhibitors of apoptosis, necroptosis, and ferroptosis (z-VAD-FMK, Necrostatin-1, and Ferrostatin-1, respectively) all exhibited marked RGC protection against IR both in mice and primary cultured RGCs, with Ferrostatin-1 conferring the best therapeutic effect, suggesting ferroptosis plays a more prominent role in the process of RGC death. We also found that activated microglia, Müller cells, immune responses, and intracellular reactive oxygen species accumulation following IR were significantly mitigated after each inhibitor treatment, albeit to varying degrees. Moreover, Ferrostatin-1 in combination with z-VAD-FMK and Necrostatin-1 prevented IR-induced RGC death better than any inhibitor alone. These findings stand to advance our knowledge of the post-IR RGC death cascade and guide future therapy for RGC protection.
GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway
Authors: Qiu Zhidong , Wang Xuehong , Yang Zebin , Liao Sicong , Dong Wei , Sun Tian , Wu Huixian , Zhang Qinqin , Pan Zhixiong , Lam Sin Man , Shui Guanghou , Jin Junfei
Published: May 2022

The effect of glucosylceramide (GlcCer) reprogramming on liver cancer metastasis remains poorly understood. In this study, we demonstrated that the protein expression of GBA1, which catalyses the conversion of GlcCer to ceramide, was downregulated in liver cancer tissue. A clinical relevance analysis revealed that low expression of GBA1 was associated with the metastatic potential of liver cancer cells. Furthermore, loss- and gain-of-function studies confirmed that low expression of GBA1 promoted metastasis of liver cancer both in vitro and in vivo. Mechanistic studies indicated that low expression of GBA1 enhanced the metastatic ability of liver cancer by promoting the epithelial-mesenchymal transition (EMT), in which Wnt signalling pathway is involved. In the plasma membrane (PM), GBA1-dependent GlcCer reprogramming increased LRP6 location in the PM leading to an interaction between GlcCer and LRP6, subsequently promoting LRP6 phosphorylation at Ser1490, and finally activating the Wnt/β-catenin signalling pathway. To our knowledge, this is the first time to be found that GlcCer interacted with a protein. In addition, the results of mass spectrometry indicated that GlcCer d18:1/18:0 was the most notably increased studied species in the PM when GBA1 was downregulated, suggesting that GlcCer d18:1/18:0 may be the major functional lipid that promotes GBA1-dependent liver cancer metastasis. Thus, GBA1-mediated GlcCer reprogramming in the PM promotes metastasis of liver cancer via activation of the Wnt/β-catenin signalling pathway, upregulation of GBA1 may be a potential therapeutic strategy to combat liver cancer metastasis.
Switches, stability and reversals in the evolutionary history of sexual systems in fish
Authors: Pla Susanna , Benvenuto Chiara , Capellini Isabella , Piferrer Francesc
Published: May 2022

Sexual systems are highly diverse and have profound consequences for population dynamics and resilience. Yet, little is known about how they evolved. Using phylogenetic Bayesian modelling and a sample of 4614 species, we show that gonochorism is the likely ancestral condition in teleost fish. While all hermaphroditic forms revert quickly to gonochorism, protogyny and simultaneous hermaphroditism are evolutionarily more stable than protandry. In line with theoretical expectations, simultaneous hermaphroditism does not evolve directly from gonochorism but can evolve slowly from sequential hermaphroditism, particularly protandry. We find support for the predictions from life history theory that protogynous, but not protandrous, species live longer than gonochoristic species and invest the least in male gonad mass. The distribution of teleosts’ sexual systems on the tree of life does not seem to reflect just adaptive predictions, suggesting that adaptations alone may not fully explain why some sexual forms evolve in some taxa but not others (Williams’ paradox). We propose that future studies should incorporate mating systems, spawning behaviours, and the diversity of sex determining mechanisms. Some of the latter might constrain the evolution of hermaphroditism, while the non-duality of the embryological origin of teleost gonads might explain why protogyny predominates over protandry in teleosts.
Observation of a phase transition within the domain walls of ferromagnetic Co3Sn2S2
Authors: Lee Changmin , Vir Praveen , Manna Kaustuv , Shekhar Chandra , Moore J. E. , Kastner M. A. , Felser Claudia , Orenstein Joseph
Published: May 2022

The ferromagnetic phase of Co3Sn2S2 is widely considered to be a topological Weyl semimetal, with evidence for momentum-space monopoles of Berry curvature from transport and spectroscopic probes. As the bandstructure is highly sensitive to the magnetic order, attention has focused on anomalies in magnetization, susceptibility and transport measurements that are seen well below the Curie temperature, leading to speculation that a “hidden” phase coexists with ferromagnetism. Here we report spatially-resolved measurements by Kerr effect microscopy that identify this phase. We find that the anomalies coincide with a deep minimum in domain wall (DW) mobility, indicating a crossover between two regimes of DW propagation. We demonstrate that this crossover is a manifestation of a 2D phase transition that occurs within the DW, in which the magnetization texture changes from continuous rotation to unidirectional variation. We propose that the existence of this 2D transition deep within the ferromagnetic state of the bulk is a consequence of a giant quality factor for magnetocrystalline anisotropy unique to this compound. This work broadens the horizon of the conventional binary classification of DWs into Bloch and Néel walls, and suggests new strategies for manipulation of domain walls and their role in electron and spin transport.
Observation of an intermediate state during lithium intercalation of twisted bilayer MoS2
Authors: Wu Yecun , Wang Jingyang , Li Yanbin , Zhou Jiawei , Wang Bai Yang , Yang Ankun , Wang Lin-Wang , Hwang Harold Y. , Cui Yi
Published: May 2022

Lithium intercalation of MoS2 is generally believed to introduce a phase transition from H phase (semiconducting) to T phase (metallic). However, during the intercalation process, a spatially sharp boundary is usually formed between the fully intercalated T phase MoS2 and non-intercalated H phase MoS2. The intermediate state, i.e., lightly intercalated H phase MoS2 without a phase transition, is difficult to investigate by optical-microscope-based spectroscopy due to the narrow size. Here, we report the stabilization of the intermediate state across the whole flake of twisted bilayer MoS2. The twisted bilayer system allows the lithium to intercalate from the top surface and enables fast Li-ion diffusion by the reduced interlayer interaction. The E2g Raman mode of the intermediate state shows a peak splitting behavior. Our simulation results indicate that the intermediate state is stabilized by lithium-induced symmetry breaking of the H phase MoS2. Our results provide an insight into the non-uniform intercalation during battery charging and discharging, and also open a new opportunity to modulate the properties of twisted 2D systems with guest species doping in the Moiré structures.
Cellular and genetic drivers of RNA editing variation in the human brain
Authors: Cuddleston Winston H. , Li Junhao , Fan Xuanjia , Kozenkov Alexey , Lalli Matthew , Khalique Shahrukh , Dracheva Stella , Mukamel Eran A. , Breen Michael S.
Published: May 2022

Posttranscriptional adenosine-to-inosine modifications amplify the functionality of RNA molecules in the brain, yet the cellular and genetic regulation of RNA editing is poorly described. We quantify base-specific RNA editing across three major cell populations from the human prefrontal cortex: glutamatergic neurons, medial ganglionic eminence-derived GABAergic neurons, and oligodendrocytes. We identify more selective editing and hyper-editing in neurons relative to oligodendrocytes. RNA editing patterns are highly cell type-specific, with 189,229 cell type-associated sites. The cellular specificity for thousands of sites is confirmed by single nucleus RNA-sequencing. Importantly, cell type-associated sites are enriched in GTEx RNA-sequencing data, edited ~twentyfold higher than all other sites, and variation in RNA editing is largely explained by neuronal proportions in bulk brain tissue. Finally, we uncover 661,791 cis-editing quantitative trait loci across thirteen brain regions, including hundreds with cell type-associated features. These data reveal an expansive repertoire of highly regulated RNA editing sites across human brain cell types and provide a resolved atlas linking cell types to editing variation and genetic regulatory effects.
Simultaneous nanocatalytic surface activation of pollutants and oxidants for highly efficient water decontamination
Authors: Zhang Ying-Jie , Huang Gui-Xiang , Winter Lea R. , Chen Jie-Jie , Tian Lili , Mei Shu-Chuan , Zhang Ze , Chen Fei , Guo Zhi-Yan , Ji Rong , You Ye-Zi , Li Wen-Wei , Liu Xian-Wei , Yu Han-Qing , Elimelech Menachem
Published: May 2022

Removal of organic micropollutants from water through advanced oxidation processes (AOPs) is hampered by the excessive input of energy and/or chemicals as well as the large amounts of residuals resulting from incomplete mineralization. Herein, we report a new water purification paradigm, the direct oxidative transfer process (DOTP), which enables complete, highly efficient decontamination at very low dosage of oxidants. DOTP differs fundamentally from AOPs and adsorption in its pollutant removal behavior and mechanisms. In DOTP, the nanocatalyst can interact with persulfate to activate the pollutants by lowering their reductive potential energy, which triggers a non-decomposing oxidative transfer of pollutants from the bulk solution to the nanocatalyst surface. By leveraging the activation, stabilization, and accumulation functions of the heterogeneous catalyst, the DOTP can occur spontaneously on the nanocatalyst surface to enable complete removal of pollutants. The process is found to occur for diverse pollutants, oxidants, and nanocatalysts, including various low-cost catalysts. Significantly, DOTP requires no external energy input, has low oxidant consumption, produces no residual byproducts, and performs robustly in real environmental matrices. These favorable features render DOTP an extremely promising nanotechnology platform for water purification.
Myriapod genomes reveal ancestral horizontal gene transfer and hormonal gene loss in millipedes
Authors: So Wai Lok , Nong Wenyan , Xie Yichun , Baril Tobias , Ma Hai-yao , Qu Zhe , Haimovitz Jasmine , Swale Thomas , Gaitan-Espitia Juan Diego , Lau Kwok Fai , Tobe Stephen S. , Bendena William G. , Kai Zhen-peng , Hayward Alexander , Hui Jerome H. L.
Published: May 2022

Animals display a fascinating diversity of body plans. Correspondingly, genomic analyses have revealed dynamic evolution of gene gains and losses among animal lineages. Here we sequence six new myriapod genomes (three millipedes, three centipedes) at key phylogenetic positions within this major but understudied arthropod lineage. We combine these with existing genomic resources to conduct a comparative analysis across all available myriapod genomes. We find that millipedes generally have considerably smaller genomes than centipedes, with the repeatome being a major contributor to genome size, driven by independent large gains of transposons in three centipede species. In contrast to millipedes, centipedes gained a large number of gene families after the subphyla diverged, with gains contributing to sensory and locomotory adaptations that facilitated their ecological shift to predation. We identify distinct horizontal gene transfer (HGT) events from bacteria to millipedes and centipedes, with no identifiable HGTs shared among all myriapods. Loss ofjuvenile hormone O-methyltransferase, a key enzyme in catalysing sesquiterpenoid hormone production in arthropods, was also revealed in all millipede lineages. Our findings suggest that the rapid evolution of distinct genomic pathways in centipede and millipede lineages following their divergence from the myriapod ancestor, was shaped by differing ecological pressures.
The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases
Authors: Jiang Zengliang , Zhuo Lai-bao , He Yan , Fu Yuanqing , Shen Luqi , Xu Fengzhe , Gou Wanglong , Miao Zelei , Shuai Menglei , Liang Yuhui , Xiao Congmei , Liang Xinxiu , Tian Yunyi , Wang Jiali , Tang Jun , Deng Kui , Zhou Hongwei , Chen Yu-ming , Zheng Ju-Sheng
Published: May 2022

Evidence from human cohorts indicates that chronic insomnia is associated with higher risk of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here, in a longitudinal cohort (n = 1809), we find that the gut microbiota-bile acid axis may link the positive association between chronic insomnia and CMD. Ruminococcaceae UCG-002 and Ruminococcaceae UCG-003 are the main genera mediating the positive association between chronic insomnia and CMD. These results are also observed in an independent cross-sectional cohort (n = 6122). The inverse associations between those gut microbial biomarkers and CMD are mediated by certain bile acids (isolithocholic acid, muro cholic acid and nor cholic acid). Habitual tea consumption is prospectively associated with the identified gut microbiota and bile acids in an opposite direction compared with chronic insomnia. Our work suggests that microbiota-bile acid axis may be a potential intervention target for reducing the impact of chronic insomnia on cardiometabolic health.
Eminuscent phase in frustrated magnets: a challenge to quantum spin liquids
Authors: Syzranov S. V. , Ramirez A. P.
Published: May 2022

A geometrically frustrated (GF) magnet consists of localised magnetic moments, spins, whose orientation cannot be arranged to simultaneously minimise their interaction energies. Such materials may host novel fascinating phases of matter, such as fluid-like states called quantum spin-liquids. GF magnets have, like all solid-state systems, randomly located impurities whose magnetic moments may “freeze” at low temperatures, making the system enter a spin-glass state. We analyse the available data for spin-glass transitions in GF materials and find a surprising trend: the glass-transition temperature grows with decreasing impurity concentration and reaches a finite value in the impurity-free limit at a previously unidentified, “hidden”, energy scale. We propose a scenario in which the interplay of interactions and entropy leads to a crossover in the permeability of the medium that assists glass freezing at low temperatures. This low-temperature, “eminuscent”, phase may obscure or even destroy the widely-sought spin-liquid states in rather clean systems.
Identification of positive and negative regulators of antiviral RNA interference in Arabidopsis thaliana
Authors: Liu Si , Chen Meijuan , Li Ruidong , Li Wan-Xiang , Gal-On Amit , Jia Zhenyu , Ding Shou-Wei
Published: May 2022

Virus-host coevolution often drives virus immune escape. However, it remains unknown whether natural variations of plant virus resistance are enriched in genes of RNA interference (RNAi) pathway known to confer essential antiviral defense in plants. Here, we report two genome-wide association study screens to interrogate natural variation among wild-collected Arabidopsis thaliana accessions in quantitative resistance to the endemic cucumber mosaic virus (CMV). We demonstrate that the highest-ranked gene significantly associated with resistance from both screens acts to regulate antiviral RNAi in ecotype Columbia-0. One gene, corresponding to Reduced Dormancy 5 (RDO5), enhances resistance by promoting amplification of the virus-derived small interfering RNAs (vsiRNAs). Interestingly, the second gene, designated Antiviral RNAi Regulator 1 (VIR1), dampens antiviral RNAi so its genetic inactivation by CRISPR/Cas9 editing enhances both vsiRNA production and CMV resistance. Our findings identify positive and negative regulators of the antiviral RNAi defense that may play important roles in virus-host coevolution.
Wearable EEG electronics for a Brain–AI Closed-Loop System to enhance autonomous machine decision-making
Authors: Shin Joo Hwan , Kwon Junmo , Kim Jong Uk , Ryu Hyewon , Ok Jehyung , Joon Kwon S. , Park Hyunjin , Kim Tae-il
Published: May 2022

Human nonverbal communication tools are very ambiguous and difficult to transfer to machines or artificial intelligence (AI). If the AI understands the mental state behind a user’s decision, it can learn more appropriate decisions even in unclear situations. We introduce the Brain–AI Closed-Loop System (BACLoS), a wireless interaction platform that enables human brain wave analysis and transfers results to AI to verify and enhance AI decision-making. We developed a wireless earbud-like electroencephalography (EEG) measurement device, combined with tattoo-like electrodes and connectors, which enables continuous recording of high-quality EEG signals, especially the error-related potential (ErrP). The sensor measures the ErrP signals, which reflects the human cognitive consequences of an unpredicted machine response. The AI corrects or reinforces decisions depending on the presence or absence of the ErrP signals, which is determined by deep learning classification of the received EEG data. We demonstrate the BACLoS for AI-based machines, including autonomous driving vehicles, maze solvers, and assistant interfaces.
Scalable single-cell RNA sequencing from full transcripts with Smart-seq3xpress
Authors: Hagemann-Jensen Michael , Ziegenhain Christoph , Sandberg Rickard
Published: May 2022

Current single-cell RNA sequencing (scRNA-seq) methods with high cellular throughputs sacrifice full-transcript coverage and often sensitivity. Here we describe Smart-seq3xpress, which miniaturizes and streamlines the Smart-seq3 protocol to substantially reduce reagent use and increase cellular throughput. Smart-seq3xpress analysis of peripheral blood mononuclear cells resulted in a granular atlas complete with common and rare cell types. Compared with droplet-based single-cell RNA sequencing that sequences RNA ends, the additional full-transcript coverage revealed cell-type-associated isoform variation.
Fast and highly sensitive full-length single-cell RNA sequencing using FLASH-seq
Authors: Hahaut Vincent , Pavlinic Dinko , Carbone Walter , Schuierer Sven , Balmer Pierre , Quinodoz Mathieu , Renner Magdalena , Roma Guglielmo , Cowan Cameron S. , Picelli Simone
Published: May 2022

We present FLASH-seq (FS), a full-length single-cell RNA sequencing (scRNA-seq) method with increased sensitivity and reduced hands-on time compared to Smart-seq3. The entire FS protocol can be performed in ~4.5 hours, is simple to automate and can be easily miniaturized to decrease resource consumption. The FS protocol can also use unique molecular identifiers (UMIs) for molecule counting while displaying reduced strand-invasion artifacts. FS will be especially useful for characterizing gene expression at high resolution across multiple samples.
In utero origin of myelofibrosis presenting in adult monozygotic twins
Authors: Sousos Nikolaos , Ní Leathlobhair Máire , Simoglou Karali Christina , Louka Eleni , Bienz Nicola , Royston Daniel , Clark Sally-Ann , Hamblin Angela , Howard Kieran , Mathews Vikram , George Biju , Roy Anindita , Psaila Bethan , Wedge David C. , Mead Adam J.
Published: May 2022

The latency between acquisition of an initiating somatic driver mutation by a single-cell and clinical presentation with cancer is largely unknown. We describe a remarkable case of monozygotic twins presenting with CALR mutation-positive myeloproliferative neoplasms (MPNs) (aged 37 and 38 years), with a clinical phenotype of primary myelofibrosis. The CALR mutation was absent in T cells and dermal fibroblasts, confirming somatic acquisition. Whole-genome sequencing lineage tracing revealed a common clonal origin of the CALR-mutant MPN clone, which occurred in utero followed by twin-to-twin transplacental transmission and subsequent similar disease latency. Index sorting and single-colony genotyping revealed phenotypic hematopoietic stem cells (HSCs) as the likely MPN-propagating cell. Furthermore, neonatal blood spot analysis confirmed in utero origin of the JAK2V617F mutation in a patient presenting with polycythemia vera (aged 34 years). These findings provide a unique window into the prolonged evolutionary dynamics of MPNs and fitness advantage exerted by MPN-associated driver mutations in HSCs.
Using generative adversarial networks for genome variant calling from low depth ONT sequencing data
Authors: Yang Han , Gu Fei , Zhang Lei , Hua Xian-Sheng
Published: May 2022

Genome variant calling is a challenging yet critical task for subsequent studies. Existing methods almost rely on high depth DNA sequencing data. Performance on low depth data drops a lot. Using public Oxford Nanopore (ONT) data of human being from the Genome in a Bottle (GIAB) Consortium, we trained a generative adversarial network for low depth variant calling. Our method, noted as LDV-Caller, can project high depth sequencing information from low depth data. It achieves 94.25% F1 score on low depth data, while the F1 score of the state-of-the-art method on two times higher depth data is 94.49%. By doing so, the price of genome-wide sequencing examination can reduce deeply. In addition, we validated the trained LDV-Caller model on 157 public Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) samples. The mean sequencing depth of these samples is 2982. The LDV-Caller yields 92.77% F1 score using only 22x sequencing depth, which demonstrates our method has potential to analyze different species with only low depth sequencing data.
Group VR experiences can produce ego attenuation and connectedness comparable to psychedelics
Authors: Glowacki David R. , Williams Rhoslyn Roebuck , Wonnacott Mark D. , Maynard Olivia M. , Freire Rachel , Pike James E. , Chatziapostolou Mike
Published: May 2022

With a growing body of research highlighting the therapeutic potential of experiential phenomenology which diminishes egoic identity and increases one’s sense of connectedness, there is significant interest in how to elicit such ‘self-transcendent experiences’ (STEs) in laboratory contexts. Psychedelic drugs (YDs) have proven particularly effective in this respect, producing subjective phenomenology which reliably elicits intense STEs. With virtual reality (VR) emerging as a powerful tool for constructing new perceptual environments, we describe a VR framework called ‘Isness-distributed’ (Isness-D) which harnesses the unique affordances of distributed multi-person VR to blur conventional self-other boundaries. Within Isness-D, groups of participants co-habit a shared virtual space, collectively experiencing their bodies as luminous energetic essences with diffuse spatial boundaries. It enables moments of ‘energetic coalescence’, a new class of embodied intersubjective experience where bodies can fluidly merge, enabling participants to include multiple others within their self-representation. To evaluate Isness-D, we adopted a citizen science approach, coordinating an international network of Isness-D 'nodes'. We analyzed the results (N = 58) using 4 different self-report scales previously applied to analyze subjective YD phenomenology (the inclusion of community in self scale, ego-dissolution inventory, communitas scale, and the MEQ30 mystical experience questionnaire). Despite the complexities associated with a distributed experiment like this, the Isness-D scores on all 4 scales were statistically indistinguishable from recently published YD studies, demonstrating that distributed VR can be used to design intersubjective STEs where people dissolve their sense of self in the connection to others.