bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding Client Difficulties in Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy: A Qualitative Analysis of Homework Reflections
Authors: Peynenburg Vanessa , Wilhelms Andrew , Sapkota Ram , Nugent Marcie , Owens Katherine , Titov Nick , Dear Blake , Hadjisatvropoulos Heather
Published: July 2022

Internet-delivered cognitive behaviour therapy (ICBT) is helpful for many clients, but less is known about the challenges clients face during ICBT, such as difficulties with skill practice, development, or maintenance. Understanding client difficulties can help therapists support clients with skill development and prevent treatment drop-out, but has not been systematically studied. This study included a conventional content analysis of clients’ responses to a homework reflection question about difficulties with lessons and skills. Data was drawn from a previously published trial of 301 clients who were randomly assigned to receive homework reflection questions during ICBT. A decreasing number of clients responded to the question about skill difficulties with each lesson. Clients who answered the question about difficulties were more engaged with ICBT (i.e., more lessons completed, logins, days enrolled in ICBT, and messages sent to therapists). Clients shared skill-specific challenges (including initial challenges and more advanced challenges), generic challenges (content or skills being cognitively draining or emotionally draining, contextual challenges, forgetfulness, limited time, and lack of familiarity with the skill), or no challenges. Thought challenging (59.6%) and graded exposure (57.5%) were associated with the greatest number of skill-specific challenges. Findings can help therapists anticipate and address common client challenges during ICBT.
Levosimendan as a “Bridge to Optimization” in Patients with Advanced Heart Failure with Reduced Ejection—A Single-Center Study
Authors: Masarone Daniele , Kittleson Michelle M. , Martucci Maria L. , Valente Fabio , Gravino Rita , Verrengia Marina , Ammendola Ernesto , Contaldi Carla , Di Palma Vito , Caiazzo Angelo , Petraio Andrea , Pollesello Piero , Pacileo Giuseppe
Published: July 2022

Background: Patients with advanced heart failure with reduced ejection fraction often cannot tolerate target doses of guideline-directed medical therapy due to symptomatic hypotension, renal dysfunction, and associated electrolyte abnormalities. While levosimendan can facilitate the titration of β-blockers in patients with advanced HFrEF, it is unclear whether ambulatory levosimendan infusions would offer the same benefit. In this prospective study, we investigate the effects of intermittent ambulatory levosimendan infusions on the uptitration of disease-modifying drugs. Methods: We enrolled 37 patients with advanced HFrEF who received repeated ambulatory infusions of levosimendan between January 2018 and January 2021. The demographic, clinical, and laboratory data were acquired 24 h before the first and the last ambulatory levosimendan infusion. Results: At the 1 year follow-up, the enrolled patients were on significantly higher doses of guideline-directed medical therapy, including bisoprolol (3.2 ± 2.8 mg vs. 5.9 ± 4.1 mg; p = 0.02), sacubitril/valsartan (41.67 ± 32.48 mg vs. 68.5 ± 35.72 mg; p = 0.01), and eplerenone (12.7 ± 8.5 mg vs. 22.8 ± 13.6 mg; p = 0.03). Furthermore, a substantial decrease in the furosemide dose was observed (123.2 ± 32.48 mg vs. 81.6 ± 19.47 mg; p < 0.0001). Conclusions: Levosimendan facilitates the optimization of disease-modifying heart failure medications in previously intolerant advanced HFrEF patients.
Detecting Sepsis in Patients with Severe Subarachnoid Hemorrhage during Critical Care
Authors: Flinspach Armin Niklas , Konczalla Jürgen , Seifert Volker , Zacharowski Kai , Herrmann Eva , Balaban Ümniye , Adam Elisabeth Hannah
Published: July 2022

Introduction: Sepsis and septic shock continue to have a very high mortality rate. Therefore, the last consensus-based sepsis guideline introduced the sepsis related organ failure assessment (SOFA) score to ensure a rapid diagnosis and treatment of sepsis. In neurosurgical patients, especially those patients with subarachnoid hemorrhage (SAH), there are considerable difficulties in interpreting the SOFA score. Therefore, our study was designed to evaluate the applicability of the SOFA for critical care patients with subarachnoid hemorrhage. Methods: Our retrospective monocentric study was registered (NCT05246969) and approved by the local ethics committee (# 211/18). Patients admitted to the Department of Neurosurgery at the Frankfurt University Hospital were enrolled during the study period. Results: We included 57 patients with 85 sepsis episodes of which 141 patients had SOFA score-positive results and 243 SIRS positive detections. We failed to detect a correlation between the clinical diagnosis of sepsis and positive SOFA or SIRS scores. Moreover, a significant proportion of sepsis that was incorrectly detected via the SOFA score could be attributed to cerebral vasospasms (p < 0.01) or a decrease in Glasgow Coma Scale (p < 0.01). Similarly, a positive SIRS score was often not attributed to a septic episode (49.0%). Discussion: Regardless of the fact that SAH is a rare disease, the relevance of sepsis detection should be given special attention in light of the long duration of therapy and sepsis prevalence. Among the six modules represented by the SOFA score, two highly modules were practically eliminated. However, to enable early diagnosis of sepsis, the investigator’s clinical views and synopsis of various scores and laboratory parameters should be highlighted. Conclusions: In special patient populations, such as in critically ill SAH patients, the SOFA score can be limited regarding its applicability. In particular, it is very important to differentiate between CVS and sepsis.
Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy
Authors: Juan Yun-Ting , Chiang Wen-Chih , Lin Wei-Chou , Yang Cheng-Wen , Chou San-Fang , Hung Ruo-Wei , Chiu Yen-Ling
Published: July 2022

Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and the updated Oxford classification of IgAN remains unclear. This study enrolled eighty-four previously untreated, biopsy-diagnosed IgAN patients. The clinical and laboratory findings were collected at the time of biopsy. Plasma levels of complement factor C5a, factor Ba and Gd-IgA1 were measured and analyzed. It was found that the levels of proteinuria positively correlated with the updated Oxford classification of mesangial hypercellularity (M), endocapillary hypercellularity (E), tubular atrophy/interstitial fibrosis (T) and crescents (C). In addition, plasma Gd-IgA1 titer was significantly elevated in IgAN patients with tubular atrophy/interstitial fibrosis (T). In separate multivariable logistic regression models, both Gd-IgA1 and factor Ba independently predict higher T scores. The results indicate that both the levels of Gd-IgA1 antibody and biomarkers of the alternative complement pathway activation reflect the Oxford classification of IgAN. Whether these biomarkers can be used to guide therapeutic decisions requires further study.
Effectiveness of Therapies Based on Mirror Neuron System to Treat Gait in Patients with Parkinson’s Disease—A Systematic Review
Authors: Lahuerta-Martín Silvia , Llamas-Ramos Rocío , Llamas-Ramos Inés
Published: July 2022

Parkinson’s disease (PD) is a neurodegenerative disease that alters gait patterns from early stages. The visuo-motor training strategies such as action observation (AO) and motor imagery (MI) that are based on the activity of the mirror neuron system (MNS) facilitate motor re-learning. The main purpose of this systematic review was to analyze the current scientific evidence about the effectiveness of MNS’s treatments (AO and MI) to treat gait in patients with PD. Searches were completed from the databases PubMed, Web of Science, and PEDro between November and December 2021. The following keywords were used: “Parkinson disease”, “mirror neurons”, “gait”, “action observation”, and “motor imagery”. Randomized control trials of the last 5 years written in English or Spanish were included. Two independent reviewers screened the articles and applied the eligibility criteria, and a third reviewer assisted in this process. A total of six articles were included for final revision. The risk of bias was assessed with the PEDro Scale. The effects of AO and MI using different outcome measures were referenced in terms of disease severity, quality of life, balance, and gait. Training with AO and MI are effective in improving disease severity, quality of life, balance, and gait in patients with PD.
Thrombelastography Compared with Multiple Impedance Aggregometry to Assess High On-Clopidogrel Reactivity in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
Authors: Gjermeni Diona , Vetter Hannah , Szabó Sofia , Anfang Viktoria , Leggewie Stefan , Hesselbarth David , Duerschmied Daniel , Trenk Dietmar , Olivier Christoph B.
Published: July 2022

Background: High on-clopidogrel platelet reactivity (HPR) following percutaneous coronary intervention (PCI) is associated with increased ischemic risk. It is unclear whether conventional definitions of HPR apply to patients with concomitant oral anticoagulation (OAC). This study aimed to compare the performance of multiple platelet aggregometry (MEA) and thrombelastography (TEG) to detect HPR in patients with atrial fibrillation (AF) and indication for an OAC. Methods: In this observational single-center cohort study, MEA and TEG were performed in patients with AF with an indication for OAC on day 1 to 3 after PCI. The primary outcome was HPR as assessed by MEA (ADP area under the curve ≥ 46 units [U]) or TEG (MAADP ≥ 47 mm), respectively. The secondary exploratory outcomes were a composite of all-cause death, myocardial infarction (MI) or stroke and bleeding, as defined by the International Society on Thrombosis and Hemostasis, at 6 months. Results: Platelet function of 39 patients was analyzed. The median age was 78 (interquartile range [IQR] was 72–82) years. 25 (64%) patients were male, and 19 (49%) presented with acute coronary syndrome. All patients received acetylsalicylic acid and clopidogrel prior to PCI. Median (IQR) ADP-induced aggregation, MAADP, TRAP-induced aggregation, and MAthrombin were 9 (6–15) U, 50 (43–60) mm, 54 (35–77) U and 65 (60–67) mm, respectively. The rate of HPR was significantly higher if assessed by TEG compared with MEA (25 [64%] vs. 1 [3%]; p < 0.001). Within 6 months, four (10%) deaths, one (3%) MI and nine (23%) bleeding events occurred. Conclusion: In patients with AF undergoing PCI, the rates of HPR detected by TEG were significantly higher compared with MEA. Conventional cut-off values for HPR as proposed by consensus documents may need to be re-evaluated for this population at high ischemic and bleeding risk. Further studies are needed to assess the association with outcomes.
Risk Factors for Periprosthetic Joint Infection after Shoulder Arthroplasty: Systematic Review and Meta-Analysis
Authors: Seok Hyun-Gyu , Park Jeong-Jin , Park Sam-guk
Published: July 2022

Periprosthetic joint infection (PJI) after shoulder arthroplasty is a devastating complication that requires several additional surgeries. The purpose of this study was to assess the evidence regarding risk factors for PJI and identify those that contribute to infection by performing a meta-analysis. We searched the PubMed, Embase, and Cochrane Library databases for studies that assessed the risk factors for infection after shoulder arthroplasty. After performing screening and quality assessment on the articles, we obtained two case-control studies and six retrospective cohort studies (total of 420 infected cases and 28,464 controls). Review Manager 5.4 was used to assess the heterogeneity and odds ratio for 20 different factors that broadly included demographic factors, perioperative factors, and comorbidities. Factors that are markedly associated with PJI after shoulder arthroplasty were male sex, operation history, revision arthroplasty, acute trauma, and non-osteoarthritis as a preoperative diagnosis. Statistical analysis revealed that diabetes mellitus, liver disease, alcohol overuse, iron-deficiency anemia, and rheumatoid arthritis were risk factors for PJI after shoulder arthroplasty. The result of analysis shows that several specific factors can be targeted to prevent infections after shoulder arthroplasty. Surgeons should consider the risk factors and perform the appropriate management for patients.
Effects of Different Durations at Fixed Intensity Exercise on Internal Load and Recovery—A Feasibility Pilot Study on Duration as an Independent Variable for Exercise Prescription
Authors: Birnbaumer Philipp , Weiner Lena , Handl Tanja , Tschakert Gerhard , Hofmann Peter
Published: July 2022

Duration is a rarely investigated marker of exercise prescription. The aim of this study was to test the feasibility of the methodological approach, assessing effects of different duration constant-load exercise (CLE) on physiological responses (internal load) and recovery kinetics. Seven subjects performed an incremental exercise (IE) test, one maximal duration CLE at 77.6 ± 4.8% V˙O2max, and CLE’s at 20%, 40%, and 70% of maximum duration. Heart rate (HR), blood lactate (La), and glucose (Glu) concentrations were measured. Before, 4, 24, and 48 h after CLE’s, submaximal IE tests were performed. HR variability (HRV) was assessed in orthostatic tests (OT). Rating of perceived exertion (RPE) was obtained during all tests. CLE’s were performed at 182 ± 27 W. HRpeak, Lapeak, V˙Epeak, and RPEpeak were significantly higher in CLE’s with longer duration. No significant differences were found between CLE’s for recovery kinetics for HR, La, and Glu in the submaximal IE and for HRV or OT. Despite no significant differences, recovery kinetics were found as expected, indicating the feasibility of the applied methods. Maximum tests and recovery tests closer to CLE’s termination are suggested to better display recovery kinetics. These findings are a first step to prescription of exercise by both intensity and duration on an individual basis.
Glycosaminoglycan, Antimicrobial Defence Molecule and Cytokine Appearance in Tracheal Hyaline Cartilage of Healthy Humans
Authors: Deņisova Arina , Pilmane Māra , Fedirko Pavlo
Published: July 2022

Hyaline cartilage is an important tracheal structure, yet little is known about its molecular composition, complicating investigation of pathologies and replacement options. Our aim was to research tracheal hyaline cartilage structure, protective tissue factors and variations in healthy humans. The tissue material was obtained from 10 cadavers obtained from the Riga Stradins University Institute of Anatomy and Anthropology archive. Tissues were stained with Bismarck brown and PAS for glycosaminoglycans, and immunohistochemistry was performed for HBD-2, HBD-3, HBD-4, IL-10 and LL-37. The slides were inspected by light microscopy and Spearman’s rank correlation coefficient was calculated. The extracellular matrix was positive across hyaline cartilage for PAS, yet Bismarck brown marked positive proliferation and growth zones. Numerous positive cells for both factors were found in all zones. All of the antimicrobial defence molecules and cytokines were found in a moderate number of cells, except in the mature cell zone with few positive cells. Spearman’s rank correlation coefficient revealed strong and moderate correlations between studied factors. Hyaline cartilage is a tracheal defence structure with a moderate number of antimicrobial defence protein and cytokine immunoreactive cells as well as numerous glycosaminoglycan positive cells. The extracellular matrix glycosaminoglycans provide structural scaffolding and intercellular signalling. The correlations between the studied factors confirm the synergistic activity of them.
Passive Acoustics to Study Marine and Freshwater Ecosystems
Authors: Buscaino Giuseppa
Published: July 2022

Passive acoustic monitoring is becoming an important tool to study the ecosystem thanks to technological improvements, high temporal resolution, relatively low cost and time effort, and the zero impact on environment and animal behavior [...]
Seasonal Evolution of Chlorophyll-a in the North Indian Ocean Associated with the Indian Ocean Dipole and Two Types of El Niño Events
Authors: Yin Zi , Dong Qing , Xiang Kunsheng , Bian Min
Published: July 2022

To investigate the main modes of interannual variation of chlorophyll-a (Chla) with seasonal evolution and its variation cycle in the North Indian Ocean based on satellite-derived products during 1998–2016, a season-reliant empirical orthogonal function (S-EOF) analysis and power spectrum analysis based on Fourier transform are applied in the study. The first three dominate modes reveal distinct Chla variability, as the S-EOF1 features by one dipole pattern have a negative anomaly in the central western Indian Ocean and a positive anomaly off the Java–Sumatra coasts, which is mainly synchronously associated with the climate indices of the positive Indian Ocean dipole (IOD) and eastern Pacific El Nino (EP-El Niño). The S-EOF2 indicates a tripolar structure with positive anomalies located in the central Indian Ocean surrounded by two negative anomalies, which is one year behind a positive IOD and EP-El Niño event. The S-EOF3 exhibits a different dipole distribution, with a positive anomaly in the central west and a negative anomaly in the southeast, synchronized or lagging behind the central Pacific El Nino (CP-El Niño). Moreover, regarding the correlation between the main modes of interannual variation and the IOD and El Nino events, the dynamic parameters (such as SST, SLA, rain, and wind) of the tropical Indo-Pacific Ocean are discussed using time-delay correlation and linear regression analysis to explain the key factors and possible influencing mechanism of the joint seasonal and interannual variations of Chla in the northern Indian Ocean.
BEM2, a RHO GTPase Activating Protein That Regulates Morphogenesis in S. cerevisiae, Is a Downstream Effector of Fungicidal Action of Fludioxonil
Authors: Sharma Anupam , Martoliya Yogita , Mondal Alok K.
Published: July 2022

Fludioxonil belongs to the phenylpyrrole group of fungicides with a broad antifungal spectrum that has been widely used in agricultural practices for the past thirty years. Although fludioxonil is known to exert its fungicidal action through group III hybrid histidine kinases, the downstream effector of its cytotoxicity is poorly understood. In this study, we utilized a S. cerevisiae model to decipher the cytotoxic effect of fludioxonil. Through genome wide transposon mutagenesis, we have identified Bem2, a Rho GTPase activating protein, which is involved in this process. The deletion of BEM2 resulted in fludioxonil resistance. Our results showed that both the GAP and morphogenesis checkpoint activities of Bem2 were important for this. We also provided the genetic evidence that the role of Bem2 in the cell wall integrity (CWI) pathway and cell cycle regulation could contribute to the fludioxonil resistance phenotype.
Exploring the Normative Foundation of Journalism Education: Nordic Journalism Educators’ Conceptions of Future Journalism and Professional Qualifications
Authors: Jaakkola Maarit , Uotila Panu
Published: July 2022

This article deals with Nordic journalism educators’ conceptions of journalism by placing the concept of normativity at the center. The values, norms and ideas concerning journalism and journalistic practice have previously been studied by journalists and journalism students around the world and in the Nordics, while the Nordic journalism educators’ conceptions have remained more or less without attention. Nevertheless, journalism educators play a crucial role in defining what journalism is and what it is not, and thus largely affect future practitioners’ ideas of journalism. Using a questionnaire that has been employed in previous studies, journalism educators within the academic journalism training in Denmark, Finland, Iceland, Norway and Sweden (n = 115) were surveyed in terms of their conceptions. It was found that the journalism educators, of which 35 per cent had a doctoral degree, still largely subscribe to the ideas of the welfare state. In addition, the ideas of slow, investigative, constructive and solutions-based journalism have gained high popularity among the Nordic educators, which, we argue, dovetails well with the pedagogical aims of journalism education.
The Association between Muscle Quantity and Overall Survival Depends on Muscle Radiodensity: A Cohort Study in Non-Small-Cell Lung Cancer Patients
Authors: van Amsterdam Wouter A. C. , Harlianto Netanja I. , Verhoeff Joost J. C. , Moeskops Pim , de Jong Pim A. , Leiner Tim
Published: July 2022

The prognostic value of CT-derived muscle quantity for overall survival (OS) in patients with non-small-cell lung cancer (NSCLC) is uncertain due to conflicting evidence. We hypothesize that increased muscle quantity is associated with better OS in patients with normal muscle radiodensity but not in patients with fatty degeneration of muscle tissue and low muscle radiodensity. We performed an observational cohort study in NSCLC patients treated with radiotherapy. A deep learning algorithm was used to measure muscle quantity as psoas muscle index (PMI) and psoas muscle radiodensity (PMD) on computed tomography. The potential interaction between PMI and PMD for OS was investigated using Cox proportional-hazards regression. Baseline adjustment variables were age, sex, histology, performance score and body mass index. We investigated non-linear effects of continuous variables and imputed missing values using multiple imputation. We included 2840 patients and observed 1975 deaths in 5903 patient years. The average age was 68.9 years (standard deviation 10.4, range 32 to 96) and 1692 patients (59.6%) were male. PMI was more positively associated with OS for higher values of PMD (hazard ratio for interaction 0.915; 95% confidence interval 0.861–0.972; p-value 0.004). We found evidence that high muscle quantity is associated with better OS when muscle radiodensity is higher, in a large cohort of NSCLC patients treated with radiotherapy. Future studies on the association between muscle status and OS should accommodate this interaction in their analysis for more accurate and more generalizable results.
The Effects of ESG Activity Recognition of Corporate Employees on Job Performance: The Case of South Korea
Authors: Jin Minsuck , Kim Boyoung
Published: July 2022

Corporate environment, society, and governance (ESG) management activities have recently been consolidated in the business ecosystem, and many firms are considering their employees’ recognition and job changes according to organizational ESG strategy. This study aims to verify the effects of ESG activity recognition of corporate employees on job performance by mediating change support behavior, innovative organization culture, and job crafting. This study designs a structural equation model with a hypotheses based on previous studies. A questionnaire survey was carried out targeting large Korean manufacturing companies, and an analysis of 329 response copies was performed. As a result, ESG activity recognition did not directly affect job crafting, but it affected job crafting with the mediation of innovative organizational culture and change support behavior. ESG activity recognition also positively affected job crafting and job performance by mediating change support behavior and an innovative organization culture. Hence, the research shows that an innovative culture and change support behavior within an organization should be considered to improve ESG management performance.
The Impact of Transport Infrastructure on Rural Industrial Integration: Spatial Spillover Effects and Spatio-Temporal Heterogeneity
Authors: Zhang Han , Wu Dongli
Published: July 2022

Industry convergence is the future trend of industrial development in rural areas and is conducive to high-quality agriculture development. To explore the development dynamics of industry convergence. This paper selects data from 31 provincial administrative regions in China from 2009 to 2019. It uses the entropy power method to measure the development quality of rural industrial integration in China and empirically studies the impact of transportation infrastructure on rural industrial integration using a spatial panel autoregressive model. The study found that: (1) from 2009–2019, the development quality of rural industrial integration is on the rise, but the development is uneven between regions; (2) transport infrastructure strongly promotes the development of rural industrial integration; (3) with the help of transport infrastructure, rural industrial integration in this region will improve the quality of rural industrial integration in the surrounding areas; and (4) the impact of transportation facilities varies in different regions and at different stages of development of rural industrial integration. The results of this paper are beneficial to improving transportation infrastructure planning and exploring the driving force of high-quality agriculture development, enriching the research of spatial land use, and providing valuable insights for developing industry convergence in other countries and regions.
Robust Gaussian and Nonlinear Hybrid Invariant Clustered Features Aided Approach for Speeded Brain Tumor Diagnosis
Authors: Almalki Yassir Edrees , Ali Muhammad Umair , Ahmed Waqas , Kallu Karam Dad , Zafar Amad , Alduraibi Sharifa Khalid , Irfan Muhammad , Basha Mohammad Abd Alkhalik , Alshamrani Hassan A. , Alduraibi Alaa Khalid
Published: July 2022

Brain tumors reduce life expectancy due to the lack of a cure. Moreover, their diagnosis involves complex and costly procedures such as magnetic resonance imaging (MRI) and lengthy, careful examination to determine their severity. However, the timely diagnosis of brain tumors in their early stages may save a patient’s life. Therefore, this work utilizes MRI with a machine learning approach to diagnose brain tumor severity (glioma, meningioma, no tumor, and pituitary) in a timely manner. MRI Gaussian and nonlinear scale features are extracted due to their robustness over rotation, scaling, and noise issues, which are common in image processing features such as texture, local binary patterns, histograms of oriented gradient, etc. For the features, each MRI is broken down into multiple small 8 × 8-pixel MR images to capture small details. To counter memory issues, the strongest features based on variance are selected and segmented into 400 Gaussian and 400 nonlinear scale features, and these features are hybridized against each MRI. Finally, classical machine learning classifiers are utilized to check the performance of the proposed hybrid feature vector. An available online brain MRI image dataset is utilized to validate the proposed approach. The results show that the support vector machine-trained model has the highest classification accuracy of 95.33%, with a low computational time. The results are also compared with the recent literature, which shows that the proposed model can be helpful for clinicians/doctors for the early diagnosis of brain tumors.
Robust Reduced-Order Active Disturbance Rejection Control Method: A Case Study on Speed Control of a One-Dimensional Gimbal
Authors: Wang Fan , Liu Peng , Xie Meilin , Jing Feng , Liu Bo , Cao Yu , Ma Caiwen
Published: July 2022

Usually, the order of active disturbance rejection control (ADRC) is equal to the relative order of the plant. To improve the control performance, a robust reduced-order method for ADRC is investigated in this paper. Firstly, frequency domain analysis shows that the lower-order extended state observer (ESO) has a smaller disturbance estimation error, so disturbance attenuation capability can be improved by reducing the order of ADRC. However, using only reduced-order ADRC will worsen the robustness of closed-loop systems. Therefore, a robust ADRC method based on a modified noise reduction disturbance observer (MNRDOB) is proposed. The main role of the MNRDOB is to improve the control performance of the closed-loop system by modifying the structure of the controlled object. In addition, the robust stability of the closed-loop control system based on the MNRDOB is discussed. Moreover, some simulations are used to demonstrate the robustness and noise suppression effects of the compound control method reduced-order ADRC with MNRDOB, and the parameter tuning method for the MNRDOB to improve the robustness of the system is given. Finally, some experiments on speed control of a one-dimensional gimbal are performed, and the results show that the proposed method is excellent in overshoot, tracking accuracy, and disturbance attenuation.
A (2+1)-Dimensional Fractional-Order Epidemic Model with Pulse Jumps for Omicron COVID-19 Transmission and Its Numerical Simulation
Authors: Zhu Wen-Jing , Shen Shou-Feng , Ma Wen-Xiu
Published: July 2022

In this paper, we would like to propose a (2+1)-dimensional fractional-order epidemic model with pulse jumps to describe the spread of the Omicron variant of COVID-19. The problem of identifying the involved parameters in the proposed model is reduced to a minimization problem of a quadratic objective function, based on the reported data. Moreover, we perform numerical simulation to study the effect of the parameters in diverse fractional-order cases. The number of undiscovered cases can be calculated precisely to assess the severity of the outbreak. The results by numerical simulation show that the degree of accuracy is higher than the classical epidemic models. The regular testing protocol is very important to find the undiscovered cases in the beginning of the outbreak.
Output Tracking Control of Random Nonlinear Time-Varying Systems
Authors: Wang Ruitao , Wang Hui , Li Wuquan , Niu Ben
Published: July 2022

This paper is concerned with the output tracking control problem for random nonlinear systems with time-varying powers. A distinct feature of this paper is that we consider time-varying powers and the second-order moment process simultaneously, which is more practical in real applications than the existing results where only one factor is considered. We propose a new design scheme, which ensures that the fourth moment of the tracking error can be adjusted to be arbitrarily small and all the states of the closed-loop system are bounded in probability. Finally, a numerical simulation is given to demonstrate the feasibility of the control idea.
Thermal-Economic Optimization of Plate–Fin Heat Exchanger Using Improved Gaussian Quantum-Behaved Particle Swarm Algorithm
Authors: Moon Joo Hyun , Lee Kyun Ho , Kim Haedong , Han Dong In
Published: July 2022

Heat exchangers are usually designed using a sophisticated process of trial-and-error to find proper values of unknown parameters which satisfy given requirements. Recently, the design of heat exchangers using evolutionary optimization algorithms has received attention. The major aim of the present study is to propose an improved Gaussian quantum-behaved particle swarm optimization (GQPSO) algorithm for enhanced optimization performance and its verification through application to a multivariable thermal-economic optimization problem of a crossflow plate–fin heat exchanger (PFHE). Three single objective functions: the number of entropy generation units (NEGUs), total annual cost (TAC), and heat exchanger surface area (A), were minimized separately by evaluating optimal values of seven unknown variables using four different PSO-based methods. By comparing the obtained best fitness values, the improved GQPSO approach could search quickly for better global optimal solutions by preventing particles from falling to the local minimum due to its modified local attractor scheme based on the Gaussian distributed random numbers. For example, the proposed GQPSO could predict further improved best fitness values of 40% for NEGUs, 17% for TAC, and 4.5% for A, respectively. Consequently, the present study suggests that the improved GQPSO approach with the modified local attractor scheme can be efficient in rapidly finding more suitable solutions for optimizing the thermal-economic problem of the crossflow PFHE.
General Relativistic Space-Time with η1-Einstein Metrics
Authors: Li Yanlin , Mofarreh Fatemah , Dey Santu , Roy Soumendu , Ali Akram
Published: July 2022

The present research paper consists of the study of an η1-Einstein soliton in general relativistic space-time with a torse-forming potential vector field. Besides this, we try to evaluate the characterization of the metrics when the space-time with a semi-symmetric energy-momentum tensor admits an η1-Einstein soliton, whose potential vector field is torse-forming. In adition, certain curvature conditions on the space-time that admit an η1-Einstein soliton are explored and build up the importance of the Laplace equation on the space-time in terms of η1-Einstein soliton. Lastly, we have given some physical accomplishment with the connection of dust fluid, dark fluid and radiation era in general relativistic space-time admitting an η1-Einstein soliton.
Protons in Gating the Kv1.2 Channel: A Calculated Set of Protonation States in Response to Polarization/Depolarization of the Channel, with the Complete Proposed Proton Path from Voltage Sensing Domain to Gate
Authors: Kariev Alisher M. , Green Michael E.
Published: July 2022

We have in the past proposed that proton motion constitutes the gating current in the potassium channel Kv1.2 and is responsible for the gating mechanism. For this to happen, there must be a proton path between the voltage-sensing domain (VSD) and the channel gate, and here we present quantum calculations that lead to a specific pair of proton paths, defined at the molecular level, with well-defined water molecule linkages, and with hydrogen bonding between residues; there is also at least one interpath crossover, where protons can switch paths. Quantum calculations on the entire 563-atom system give the complete geometry, the energy, and atomic charges. Calculations show that three specific residues (in the pdb 3Lut numbering, H418, E327, R326), and the T1 intracellular moiety, all of which have been shown experimentally to be involved in gating, would necessarily be protonated or deprotonated in the path between the VSD and the gate. Hydroxyl reorientation of serine and threonine residues are shown to provide a means of adjusting proton directions of motion. In the deprotonated state for K312, a low energy state, our calculations come close to reproducing the X-ray structure. The demonstration of the existence of a double proton path between VSD and gate supports the proposed proton gating mechanism; when combined with our earlier demonstration of proton generation in the VSD, and comparison with other systems that are known to move protons, we are close to achieving the definition of a complete gating mechanism in molecular detail. The coupling of the paths to the VSD, and to the PVPV section that essentially forms the gate, can be easily seen from the results of the calculation. The gate itself remains for further computations.
A Review on Fabrication of Cylindrical and Rotating Parts by Thermoelectric-Erosion Based Turning Processes
Authors: Chaubey Sujeet Kumar , Gupta Kapil
Published: July 2022

Nowadays, advanced turning processes are extensively being adopted to perform different types of turning operations such as straight turning, taper turning on Hastelloy, Nimonic, and Inconel, stainless steel, and tool steel to fabricate better quality cylindrical and rotating parts such as miniature-bars, miniature-pins, miniature-electrodes, and miniature-tools. This paper presents a review of the previous research conducted on the turning of miniature cylindrical bars using thermoelectric-erosion based turning processes namely thermoelectric-erosion turning (TET) and wire-assisted thermoelectric-erosion turning (WTET). It also highlights work and tool electrode materials, types of dielectrics, detailed specifications of turning, types of turning, process parameters, performance measures, advantages and limitations, and key findings. The paper ends with conclusions and future research directions. This paper aims to facilitate researchers and scholars by highlighting the potential and capabilities of TET and WTET processes and providing relevant information for ease of fabrication of miniature parts and components from a wide range of difficult-to-machine materials.
Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota
Authors: Mineshita Yui , Sasaki Hiroyuki , Kim Hyeon-ki , Shibata Shigenobu
Published: July 2022

Postprandial hyperglycemia increases the risk of mortality among patients with type 2 diabetes and cardiovascular diseases. Additionally, the gut microbiota and type 2 diabetes and cardio-vascular disease are known to be correlated. Currently, fasting blood glucose is the primary in-dex for the clinical diagnosis of diabetes; however, postprandial blood glucose is associated with the risk of developing type 2 diabetes and cardiovascular disease and mortality. Therefore, the dynamic change in blood glucose levels under free-living conditions is considered an important and better marker than fasting glucose levels to study the relationship between glucose levels and microbiota. Here, we investigated the relationship between fasting and postprandial glucose levels and microbiota under free-living conditions for one week in older adults. In addition, in order to clarify the relationship between blood glucose level and intestinal bacteria, postprandial 4-h AUC was calculated and the correlation with gut bacteria was investigated. As a result of the present study, we observed many of the most significant correlations between the gut bacteria and the peak glucose levels after dinner and the 4-h AUC after dinner. Together, these findings suggest that the individual pattern of microbiota may help to predict post-dinner hyperglycemia and the risk of abnormal glucose metabolism, such as diabetes.
The Common and Unique Pattern of Microbiome Profiles among Saliva, Tissue, and Stool Samples in Patients with Crohn’s Disease
Authors: Shin Seung Yong , Kim Sounkou , Choi Ji Won , Kang Sang-Bum , Kim Tae Oh , Seo Geom Seog , Cha Jae Myung , Chun Jaeyoung , Jung Yunho , Im Jong Pil , Bang Ki Bae , Choi Chang Hwan , Park Soo-Kyung , Park Dong Il
Published: July 2022

This study aimed to elucidate common and unique microbiome patterns in saliva, intestinal tissue biopsy, and stool samples from patients with Crohn’s disease (CD). Saliva, tissue, and stool samples from patients with CD were prospectively collected. Quantitative and phylogenetic analyses of 16s rRNA sequencing data were performed with bioinformatical pipelines. A total of 30 patients were enrolled in this study. The composition of major microbial taxa was similar between tissue and stool samples. A total of 11 of the 20 most abundant microbiota were found in both samples. The microbial community in saliva was significantly distinct from that in tissue and stool. The major species of microbiota and their composition also differed significantly from those of tissue and stool samples. However, Streptococcus and Prevotella are common genera in saliva, tissue, and stool microbiome. The abundance of Streptococcus, Pantoea, and Actinomyces from the saliva sample group were significantly different, varying with the location of the inflammation. Saliva has a distinct microbial community compared with tissues and stools in patients with CD. Prevotella and Streptococcus, which are commonly observed in saliva, stool, and tissue, can be considered a potential biomarker related to the diagnosis or prognosis of CD.
Adaptation of Brucella melitensis Antimicrobial Susceptibility Testing to the ISO 20776 Standard and Validation of the Method
Authors: Tscherne Alina , Mantel Enrico , Boskani Talar , Budniak Sylwia , Elschner Mandy , Fasanella Antonio , Feruglio Siri L. , Galante Domenico , Giske Christian G. , Grunow Roland , Henczko Judit , Hinz Christin , Iwaniak Wojciech , Jacob Daniela , Kedrak-Jablonska Agnieszka , Jensen Veronica K. , Johansen Tone B. , Kahlmeter Gunnar , Manzulli Viviana , Matuschek Erika , Melzer Falk , Nuncio Maria S. , Papaparaskevas Joseph , Pelerito Ana , Solheim Margrete , Thomann Susanne , Tsakris Athanasios , Wahab Tara , Weiner Marcin , Zoeller Lothar , Zange Sabine
Published: July 2022

Brucellosis, mainly caused by Brucella (B.) melitensis, is associated with a risk of chronification and relapses. Antimicrobial susceptibility testing (AST) standards for B. melitensis are not available, and the agent is not yet listed in the EUCAST breakpoint tables. CLSI recommendations for B. melitensis exist, but they do not fulfill the requirements of the ISO 20776 standard regarding the culture medium and the incubation conditions. Under the third EU Health Programme, laboratories specializing in the diagnostics of highly pathogenic bacteria in their respective countries formed a working group within a Joint Action aiming to develop a suitable method for the AST of B. melitensis. Under the supervision of EUCAST representatives, this working group adapted the CLSI M45 document to the ISO 20776 standard after testing and validation. These adaptations included the comparison of various culture media, culture conditions and AST methods. A Standard Operation Procedure was derived and an interlaboratory validation was performed in order to evaluate the method. The results showed pros and cons for both of the two methods but also indicate that it is not necessary to abandon Mueller–Hinton without additives for the AST of B. melitensis.
iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments
Authors: dos Santos José Diogo Neves , João Susana Afonso , Martín Jesús , Vicente Francisca , Reyes Fernando , Lage Olga Maria
Published: July 2022

Oceans hold a stunning number of unique microorganisms, which remain unstudied by culture-dependent methods due to failures in establishing the right conditions for these organisms to grow. In this work, an isolation effort inspired by the iChip was performed using marine sediments from Memoria beach, Portugal. The isolates obtained were identified by 16S rRNA gene analysis, fingerprinted using BOX-PCR and ERIC-PCR, searched for the putative presence of secondary metabolism genes associated with polyketide synthase I (PKS-I) and non-ribosomal peptide synthetases (NRPS), screened for antimicrobial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213, and had bioactive extracts dereplicated by LC/HRMS. Of the 158 isolated strains, 96 were affiliated with the phylum Actinomycetota, PKS-I and NRPS genes were detected in 53 actinomycetotal strains, and 11 proved to be bioactive (10 against E. coli, 1 against S. aureus and 1 against both pathogens). Further bioactivities were explored using an “one strain many compounds” approach, with six strains showing continued bioactivity and one showing a novel one. Extract dereplication showed the presence of several known bioactive molecules and potential novel ones in the bioactive extracts. These results indicate the use of the bacteria isolated here as sources of new bioactive natural products.
Clay Mineral Assemblages in the Cretaceous Volcanogenic–Sedimentary Rocks of the North-Western Part of the Transition Zone from the Asian Continent to the Pacific Ocean
Authors: Mozherovsky Anatoly V.
Published: July 2022

In this study, clay and non-clay minerals in the cement of Cretaceous volcanogenic–sedimentary rocks from the bottom of the marginal seas of the north-western Pacific Ocean and adjacent areas were studied. Corrensite and mixed-layer chlorite–smectite, rectorite and mixed-layer illite–smectite, chlorite, swelling chlorite (?), illite, kaolinite, smectite (?), calcite, ankerite, barite, gypsum, epsomite, zeolites (laumontite, analcime, and stilbite), cristobalite, and quartz were determined. The following are the indicative properties: (a) minerals: corrensite and rectorite; (b) associations: corrensite–chlorite, corrensite–chlorite–laumontite, corrensite–epsomite–authigenic calcite, and quartz–illite. Such minerals indicate that the thickness of the accumulated sediments in the studied basins could reach three to five kilometers and that the temperature of their formation could be higher than 150 °C. Transformations in the process of diagenesis and epigenesis occur in two directions: smectite–rectorite–mica, with an excess of potassium, and smectite–corrensite–chlorite, with an excess of magnesium. The chlorite–corrensite association may indicate conditions favorable for seawater evaporation, and the presence of laumontite in the corrensite–chlorite association suggests a periodic supply of calcium to the sedimentation basin. The illite–kaolinite association is probably associated with coal accumulation in epicontinental conditions and a warm humid climate in nearby areas. Periods of sedimentation, possibly associated with global climate events, were identified: 113–120, 110–113, 105–110, 93–95, 72–83 and 61–72 Ma. The established time intervals and mineral associations can serve as benchmarks for stratigraphic constructions in reconstructing the physicochemical, climatic parameters, and conditions of Cretaceous volcanogenic–sedimentary strata accumulation.
13C CP MAS NMR and DFT Studies of 6-Chromanyl Ethereal Derivatives
Authors: Wałejko Piotr , Szeleszczuk Łukasz , Pisklak Dariusz Maciej , Wojtulewski Sławomir
Published: July 2022

Vitamin E consists of a group of compounds including α- β- γ- and δ-tocopherols and α- β- γ- and δ-tocotrienols, containing the chroman-6-ol system. The recognition of the structural and dynamic properties of this system, present in all vitamers, seems to be important for the full explanation of the mechanism of the biological activity of vitamin E. This paper presents results of the structural analysis of the chosen 6-chromanyl ethereal derivatives using experimental (13 C NMR-in solution and solid state, as well as variable temperature experiments; single crystal X-ray diffraction) and theoretical (DFT) methods. For one of the studied compounds, 2,2,5,7,8-pentamethyl-6-((tetrahydro-2H-pyran-2-yl)oxy) chroman, the splitting of some signals was observed in the 13C dynamic NMR spectra. This observation was explained by the application of a conformational analysis and subsequent DFT optimization, followed by the calculation of NMR properties.