bluuebunny/crossref_metadata_2025 huggingface dataset:
Lagoon Hero: de la gamificación en el aula a la preservación de la biodiversidad
Authors: Torres-Parra Edwin Andrés , Linares-Gómez Ismenia Lilibeth , Martínez-Bejarano Fency Vianey , Cárdenas Yiny Paola , Velandia Jeiner
Published: July 2020

El presente artículo establece la implementación del modelo ADDIE —análisis, diseño, desarrollo, implementación y evaluación— en el diseño de un aplicativo móvil como componente tecnológico de una propuesta didáctica para el fomento de actitudes de cuidado y preservación de la biodiversidad de los humedales de Cundinamarca, Colombia. El aplicativo está orientado metodológicamente bajo los lineamientos de investigación acción, cuyo objetivo es reflexionar y transformar el entorno de las prácticas pedagógicas en el que se ejecuta la investigación; por eso como estrategia para el aprendizaje significativo se utiliza la gamificación y la realidad aumentada, pues se identificaron como tendencias pedagógicas y tecnológicas que en procesos educativos actuales permiten generar escenarios y herramientas para el fomento o el desarrollo de competencias disciplinares de maneras diferentes, vivenciales y acordes con las demandas de la sociedad del conocimiento. Como parte de las conclusiones se identificó que este tipo de herramientas no solo causa efectos positivos en los procesos de aprendizaje de los estudiantes, sino que también son un aporte para los docentes, pues facilitan la apropiación de conceptos de forma atractiva y les muestra cómo la evaluación formativa, mediante la implementación de la actividad interactiva, hace que la evaluación sea menos intrusiva, logrando un mejor desempeño y el cumplimiento de las competencias por parte de los estudiantes.
Quiescent stem cell marker genes in glioma gene networks are sufficient to distinguish between normal and glioblastoma (GBM) samples.
Authors: Mukherjee Shradha
Published: July 2020

Grade 4 glioma or GBM has poor prognosis and is the most aggressive grade of glioma. Accurate diagnosis and classification of tumor grade is a critical determinant for development of treatment pathway. Extensive genomic sequencing of gliomas, different cell types, brain tissue regions and advances in bioinformatics algorithms, have presented an opportunity to identify molecular markers that can complement existing histology and imaging methods used to diagnose and classify gliomas. ‘Cancer stem cell theory’ purports that a minor population of stem cells among the heterogeneous population of different cell types in the tumor, drive tumor growth and resistance to therapies. However, characterization of stem cell states in GBM and ability of stem cell state signature genes to serve as diagnostic or prognostic molecular markers are unknown. In this work, two different network construction algorithms, Weighted correlation network analysis (WGCNA) and Multiscale Clustering of Geometric Network (MEGENA), were applied on publicly available glioma, control brain and stem cell gene expression RNA-seq datasets, to identify gene network regulatory modules associated with GBM. Both gene network algorithms identified consensus or equivalent modules, HuAgeGBsplit_18 (WGCNA) and c1_HuAgeGBsplit_32/193 (MEGENA), significantly associated with GBM. Characterization of HuAgeGBsplit_18 (WGCNA) and c1_HuAgeGBsplit_32/193 (MEGENA) modules showed significant enrichment of rodent quiescent stem cell marker genes (GSE70696_QNPbyTAP). A logistic regression model built with eight of these quiescent stem cell marker genes (GSE70696_QNPbyTAP) was sufficient to distinguish between control and GBM samples. This study demonstrates that GBM associated gene regulatory modules are characterized by diagnostic quiescent stem cell marker genes, which may potentially be used clinically as diagnostic markers and therapeutic targets in GBM.
Multidisciplinary Treatment for Colorectal Liver Metastases in Elderly Patients
Authors: Hata Taigo , Mise Yoshihiro , Ono Yoshihiro , Sato Takafumi , Inoue Yosuke , Ito Hiromichi , Takahashi Yu , Yanaga Katsuhiko , Saiura Akio
Published: July 2020

Background: Limited data describe the therapeutic practice and outcomes of colorectal liver metastases (CRLMs) in elderly patients. We aimed to evaluate the impact of age on multidisciplinary treatment for CRLMs. Methods: We reviewed treatment and outcomes for patients in different age groups who underwent initial hepatectomy for CRLMs from 2004 through 2012.Results: We studied 462 patients who were divided into three groups by age: ≤ 64 years (n = 265), 65–74 years (n = 151), and ≥ 75 years (n = 46). The rate of major hepatectomy and incidence of postoperative complications did not differ between groups. Adjuvant chemotherapy was used less in the ≥ 75 -year group (19.6%) than that in the ≤ 64 (54.3%) or 65–74 age group (43.5%). Repeat hepatectomy for liver recurrence was performed less in the ≥ 75 -year group (35%) than in the ≤ 64 (57%) or 65–74 (66%) age group. The 5-year disease-specific survival (DSS) rate of 44.2% in the ≥ 75 -year group was lower than in the ≤ 64 (59.0%) or 65–74 (64.7%) age group. Multivariate analysis revealed age ≥ 75 years was an independent predictor of poor DSS.Conclusions: Liver resection for CRLMs can be performed safely in elderly patients. However, repeat resection for recurrence are performed less frequently in the elderly, which may lead to the poorer disease-specific prognosis.
Factors affecting bone maturation in Chinese girls aged 4-8 years with isolated premature thelarche
Authors: Su Huiping , Su Zhe , Pan Lili , Wang Li , Xu Zhongwei , Peng Gang , Li Xianglei
Published: July 2020

Background: In isolated premature thelarche (IPT) girls, bone age (BA) is considered consistent with chronological age. However, IPT girls confirmed by gonadotropin-releasing hormone (GnRH) stimulation test could show another trend. We analysed BA and possible potentiating factors in girls aged 4-8 years with IPT.Methods: IPT girls aged 4-8 years hospitalized from January 2015 to April 2018 at Shenzhen Children's Hospital were divided into two groups with advanced BA of 2 years as the cut-off. Body mass index (BMI) and hormone levels were the main outcome measures, and regression analysis was used to identify independent risk factors. IPT girls were divided into subgroups separately according to the levels of BMI standard deviation score (SDS), insulin-like growth factor-1 (IGF-1) SDS and dehydroepiandrosterone sulfate (DHEAS) SDS to compare BA.Results: Overall, 423 subjects were classified into the advanced BA (48.7%, n=206) and control groups (51.3%, n=217). The advanced BA group had significantly higher BMI SDS, DHEAS SDS, IGF-1 SDS, androstenedione and serum fasting insulin and significantly lower sex hormone binding globulin (all p<0.001). IGF-1 SDS (OR=1.926, p＜0.001), BMI SDS (OR=1.427, p=0.001) and DHEAS SDS (OR=1.131, p=0.005) were independent risk factors for advanced BA. In the multiple linear regression model, IGF-1 SDS, BMI SDS and DHEAS SDS were the strongest predictors of advanced BA, accounting for 19.3% of the variance. According to BMI, 423 patients were classified into three groups: normal weight (56.03%, n=237 ), overweight (19.15%, n=81) and obesity (24.82%, n=105). The proportion of advanced BA in obesity was significantly higher than that of normal weight and overweight (χ2=18.088, P＜0.001). In a subgroup with normal weight, higher IGF-1 SDS (p=0.009) and DHEAS SDS (p=0.003) affected BA advancement independent of BMI SDS. Conclusions: Girls with IPT confirmed by GnRH stimulation test aged 4-8 years might have significantly advanced BA. Obesity was highly associated with advanced BA. Age-specific serum IGF-1 SDS and DHEAS SDS were risk factors for BA advancement independent of BMI.
Comparative transcriptomic profiling of myxomatous mitral valve disease in the Cavalier King Charles Spaniel
Authors: Markby Greg , Macrae Vicky , Corcoran Brendan , Summers Kim
Published: July 2020

Background. Almost all elderly dogs develop myxomatous mitral valve disease by the end of their life, but the Cavalier King Charles Spaniel (CKCS) has a heightened susceptibility, frequently resulting in death at a young age and suggesting that there is a genetic component to the condition in this breed. Transcriptional profiling can reveal the impact of genetic variation through differences in gene expression levels. The aim of this study was to determine whether expression patterns were different in mitral valves showing myxomatous degeneration from CKCS dogs compared to valves from non-CKCS dogs. Results. Gene expression patterns in three groups of canine valves resulted in distinct separation of normal valves, diseased valves from CKCS and diseased valves from other breeds; the latter were more similar to the normal valves than were the valves from CKCS. Gene expression patterns in diseased valves from CKCS dogs were quite different from those in the valves from other dogs, both affected and normal. Patterns in all diseased valves (from CKCS and other breeds) were also somewhat different from normal non-diseased samples. Analysis of differentially expressed genes showed enrichment in GO terms relating to cardiac development and function and to calcium signalling canonical pathway in the genes down-regulated in the diseased valves from CKCS, compared to normal valves and to diseased valves from other breeds. F2 (prothrombin) (CKCS diseased valves compared to normal) and MEF2C pathway activation (CKCS diseased valves compared to non-CKCS diseased valves) had the strongest association with the gene changes. A large number of genes that were differentially expressed in the CKCS diseased valves compared with normal valves and diseased valves from other breeds were associated with cardiomyocytes including CASQ2, TNNI3 and RYR2. Conclusion. Transcriptomic profiling identified gene expression changes in CKCS diseased valves that were not present in age and disease severity-matched non-CKCS valves. These genes are associated with cardiomyocytes, coagulation and extra-cellular matrix remodelling. Identification of genes that vary in the CKCS will allow exploration of genetic variation to understand the aetiology of the disease in this breed, and ultimately development of breeding strategies to eliminate this disease from the breed.
The influence of Electronic Health Record use on collaboration among medical specialties
Authors: Vos Janita F.J. , Boonstra Albert , Kooistra Arjen , Seelen Marc , Offenbeek Marjolein A.G. van
Published: July 2020

Background: One of the main objectives of Electronic Health Records (EHRs) is to enhance collaboration among healthcare professionals. However, our knowledge of how EHRs actually affect collaborative practices is limited. This study examines how an EHR facilitates and constrains collaboration in five outpatient clinics.Methods: We conducted an embedded case study at five multidisciplinary outpatient clinics of a Dutch hospital that had implemented an organization-wide EHR. Data were collected through semi-structured interviews with representatives of medical specialties, administration, nursing, and management. Documents were then analyzed to contextualize these data. We examined the following six collaborative affordances of EHRs: (1) portability, (2) co-located access, (3) shared overviews, (4) mutual awareness, (5) messaging, and (6) orchestrating.Results: Our findings demonstrate how an EHR will simultaneously both facilitate and constrain collaboration among specialties and disciplines. Affordances that were inscribed in the system for collaboration purposes were not fully actualized in the focal hospital because:(a) The EHR helps health professionals coordinate patient care on an informed basis at any time and in any place but only allows asynchronous patient record use. (b) The comprehensive patient file affords joint clinical decision-making based on shared data, but specialty- and discipline-specific user-interfaces constrain mutual understanding of that data. Moreover, not all relevant information can be easily shared across specialties and outside the hospital. (c) The reduced necessity for face-to-face communication saves time but is experienced as hindering collective responsibility for a smooth workflow. (d) The EHR affords registration at the source and full registration of activities through orders, but the heightened administrative burden for physicians and the strict authorization rules on inputting data constrain the flexible, multidisciplinary collaboration. (e) While the EHR affords a complete overview, information overload occurs due to the parallel generation of individually owned notes and the high frequency of asynchronous communication through messages of varying clinical priority.Conclusions: For the optimal actualization of EHRs’ collaborative affordances in hospitals, coordinated use of these affordances by health professionals is a prerequisite. Such coordinated use requires organizational, technical, and behavioral adaptations. Suggestions for hospital-wide policies to enhance trust in both the EHR and in its coordinated use for effective collaboration are offered.
Eye tracking and virtual reality in the rehabilitation of mobility of hemianopia patients: a user experience study
Authors: Gestefeld Birte , Koopman Jan , Vrijling Anne , Cornelissen Frans W. , de Haan Gera
Published: July 2020

Purpose: To test the usability of eye tracking and virtual reality during vision rehabilitation training of hemianopia patients.

Methods: Individuals with hemianopia (n = 13) and normal-sighted controls (n = 4) performed various exercises that are commonly used in vision rehabilitation for mobility, while wearing a head-mounted eye tracker or a head-mounted virtual reality (VR) display. Occupational therapists (n = 4) guided them through the exercises. All participants (including therapists) filled out a questionnaire, assessing their experience with the used device. Individuals with hemianopia were split into three groups according to their stage in vision rehabilitation therapy and performed 1 (beginner), 2 (intermediate) or 3 (advanced) different exercises.

Results: Individuals with hemianopia rated the mobile eye tracker with a score of 3.97 ± 0.5 points (beginner), 3.8 ± 0.5 points (intermediate) and 4 ± 0 points (advanced) the corresponding occupational therapists with a score of 3.6 ± 0.6, 3.4 ± 0.9 and 3.87 ± 0.6 points (out of a maximum of 4 points). The VR headset was rated with 3.9 ± 0.5 points by individuals with hemianopia, 3.8 ± 0.5 points by normal-sighted controls and 2.5 ± 1.4 points by the occupational therapist in a virtual hallway scenario. In a street-crossing scenario, it was rated with 3.7 ± 0.5 points by individuals with hemianopia, 3.7 ± 0.8 points by controls and 2.8 ± 1.2 by occupational therapists. In a walking along a pavement scenario the individual with hemianopia gave 4 ± 0 points and the controls 3.8 ± 0.4 points on average.

Conclusions: Both devices were seen as useful additions to vision rehabilitation therapy, as they enable better feedback to patients and the opportunity to do different exercises at different levels of difficulty.
Revista completa
Authors: Hamut'ay Revista
Published: July 2020

Revista completa
Monitorización parental de adolescentes con ayuda de la tecnología
Authors: Carrera Herrera Xiomara Paola , Beltrán Guevara Patricia Maricela , Villalta Córdova Bertha María
Published: July 2020

La familia se encuentra atravesando algunas transformaciones sociales y los padres actualmente están preocupados por las conductas y las actitudes de sus hijos cuando se encuentran solos. En los tiempos modernos y con la irrupción de las tecnologías es necesario informarse y aprender cómo se deben utilizar estos recursos en las relaciones familiares, de ahí parte la importancia y la necesidad de que los padres de familia hagan conciencia sobre una supervisión más cercana de las actividades de sus hijos, debido a estos antecedentes se ha generado esta investigación, planteando como objetivo principal el identificar el uso de aplicaciones tecnológicas en el proceso de monitorización parental.
Business risks and their impact on business future concerning the entrepreneur’s experience with business bankruptcy: case of Czech Republic
Authors: Dvorský Ján , Ključnikov Aleksandr , Polách Jiří
Published: July 2020

The article aims to determine the difference in the perception of selected business risks and their impact on the future of business concerning the entrepreneur’s experience with business bankruptcy. The case study involved 73 small and medium-sized enterprises (SMEs) with experience of business bankruptcy and 381 SMEs without the experience of business bankruptcy from the Czech Republic (CR). Linear regression models were used to verify statistically significant causal relationships between selected indicators of the most significant business risks and respondents’ perceptions of the future of business. The results brought interesting findings. The attitudes of entrepreneurs show that personnel, market, and financial risk are among the three most significant business risks. Experience with business failure is not a significant factor in determining the impact of market indicators on the business’s perceived future. The adequacy of sales of services and products has the greatest impact. The experience of the bankruptcy of SMEs is important in financial risk attitudes. According to entrepreneurs who have no experience with bankruptcy, the perception of financial performance has the greatest direct impact on the future of business. Conversely, for entrepreneurs who have experienced bankruptcy, the ability to properly manage financial risk on the company’s future has the greatest direct impact.
THE SPIRITUALITY OF PEDICAB DRIVERS A CASE STUDY AT TRUNOJOYO STREET BOJONEGORO CITY EAST JAVA
Authors: Izza Yogi Prana
Published: July 2020

This paper aims to describe the spirituality of "suburban humans" who in this case are pedicab drivers on the Trunojoyo road in Bojonegoro city. The anthropological approach is used with the focus on: the meaning and needs of spirituality for pedicab drivers, the spiritual dimension of pedicab drivers and the factors that influence their spirituality. The results of this study are expected to be input into the development and improvement of spirituality as a basic human need.
SYATAHAT OF THE SUFIS AND THE ISSUE OF HUMAN CONSCIOUSNESS
Authors: Zulkarnain Dzikrullah
Published: July 2020

ABSTRACTThis research empasizes on digging the consept of Syat{ah{at of Sufis where several tasawuf companion showed their psychological condition up on paradoct position, switces themselves on God position. Then, trought researching on Syat{ah{at of Sufis in psychological approach, researcher found several conclusions; i.e. (a) etimologically, Syat}ah}at means shaking (al-h}arakah); (b) terminologigally, Syat{ah{at of Sufis means any speeches that stranged to be heard by its audience when Sufis reached wajd or wujud level. The factors that force the Sufis said Syat{ah{at were: (1) the strong emotional feelings and rumbled spiritual extasy (wajd), (2) experiences self unification (ittih}ad), (3) Sufis are in extacy condition (sakr), (4) Sufis hear the signal of divinity within them who invites self-union, so they positioned himself as God, and (5) they loss of self-consciousness; Additionally, the researchers added the other factors, i.e. (1) the Sufis movement comes from tawajud (salat, dhikr, meditation, contemplation, thought) on to the wajd or ecstasy level, (2) when Sufis heart is suddenly controlled by Allah Almighty (warid al-ilahiyyah), so he was no longer able to control their consciousness, and (3) absence of prejudice that the Sufis are united with God, because when that feeling comes, then they really had split (infisal). In other hand, Syat{ah{at of Sufis in psychological perspective, this study focused on transpersonal psychology, researchers tried to draw the conclusion that remarks Syat{ah{at in grammatical word used is a combination of words which are not common to say by common, because the context is only for Allah. Those unusual utterances are manifestation of Sufis psychology themselves, when saying syat}ah}at , Sufis do not realize whatever they have been said.
Response to Javanese Tradition in Kiai Shaleh Darat’s Writings
Authors: Ahmad Nur
Published: July 2020

The process of Islamization of Java is totally obscure. Because of the dark history of their conversion into Islam, and of misleading information from some orientalists, some members of Muslim communities mistaken some rituals as animistic and un-Islamic. On the other extreme, ironically, theyconfuse creed that is in opposition to IslamwiththeIslamic orthodoxy. For the former, slametan is the perfect example, meanwhile, for the latter, sadjen becomes its representative. This paper aims to describe and analyzeKiai Ṣaleh Darat’s response to both slametan and sadjen, some abangan customs (adat)– as Geertz would like to call – written down in Ṣaleh’s works. Based on this analysis, we also would provide a response to the error Geertz makes about the animistic attribute of slametan. In contrast to his imagination, slametanis perfectly Islamic and based on Islamic practice of communities from which Javanese Islam originate. In addition, Kiai Shaleh accepts the ritual and gives it Islamic justification. Meanwhile, sadjen – as Kiai Shaleh points out – is totally an opposition to the most fundamental credo of Islam, namely the Unity of God, “Tauhid.”
Sufistic Values in Suryomentaram Kawruh Jiwo
Authors: Nikmaturrahmah Nikmaturrahmah , Musyafiq Ahmad
Published: July 2020

The teaching of Sufism contains the noble values. The noble values can also be found in a variety of Javanis traditions and local wisdom, one of them is Kawruh Jiwa Ki Ageng Suryomentaram. The concept of Kawruh Jiwa is a method to achieve the soul condition without ego, it’s also called “man without attribute”, is relevant to the teachings of Sufism in the fight against the lust, and pursue the noble values of Sufistic wisdom. This study intends to reveal the Sufistic values in Kawruh Jiwa Ki Ageng Suryomentaram, by analyzing the relevance between the values in maqamat and ahwal with Kawruh Jiwa concept. The results showed that the concept of Kawruh Jiwa relevance to the values of maqamat and ahwal such as repentance (tawbah), asceticism (zuhd), patient (sabr), confidence (tawakkul), mujahadah, qanaah, tawadhu, and itsar. Thus, it can be said that the Kawruh Jiwa relevance with the Sufistic noble values, and reinforce those values in the frame of local wisdom.
Exploring the Connections between Spirituality and Morality: Phenomenology Study on Tijaniyyah Sufi Order’s Congregation in Jatibarang Brebes
Authors: Saepudin Saepudin
Published: July 2020

This article aims at revealing the connections between aspects of spirituality and morality which are able to present happiness and tranquility. One of them is through the approach implicitly implemented in aurad ritual, which is performed by Tijaniyyah sufi order’s congregation at Jatibarang Brebes. It has proven to breaking down the value of the community from bad to good. This phenomenological study, investigates the emergence of the congregation was caused over the human behavior decadence in the midst of modern society. System carried out by Tijaniyyah in renewing the morality of society following the manhaj of prophet Muhammad i.e. through akhlakiyah (ethic) approach. To prove the truth of this Tijaniyyah mission against the moral improvement of society, congregations do a ritual that is lazimah dan wadifah which aims at forming behavior change, especially on its followers. The results of this study show that Tijaniyyah’s congregations at Jatibarang Brebes assert the existence of a sense of serenity in their own life. In addition, they always istiqamah (consistent and commitment) in dealing with any mundane problem.
The Spirituality of Music in The Light of al-Sarrāj and al-Hujwīrī
Authors: Rahman Luthfi
Published: July 2020

This paper discusses spiritual and fiqh (Islamic Jurisprudence) aspects of music in relation to two classical Sufi masters i.e, Abū Naṣr al-Sarrāj al-Ṭūsi (378/988) and Alī b. Uthmān al-Jullabi al-Ḥujwīrī (465/1072). It particularly focuses on their two master­pieces i.e., Kitāb al-Luma’ and Kashfu al-Maḥjūb. It further compares three specific points; permissibility of music, listening to Quran and poetry and the state of ecstasy in auditing music. Based on this study, it is found that the Sufi Masters observed the matter of spirituality can be combined and approached with strict obedience through rigidly practicing fiqh. Yet, it should be noted that spirituality of music will be of course beyond dicta of jurisprudence by the fact that spirituality is inward thing while shari’ah (which is narrowly used to point religious law) is outward one. As to the matter of listening to Quran and poetry, both sufi masters offer more emphasis on listening Qur’an than poetry or odes. Nevertheless, they did not negate the importance of listening to poetry, poems and odes. It is evidenced by a ḥadīth stating that indeed there is wisdom in every poetry. In terms of the state of ecstasy, the two masters offer tawājud (artificial wajd). Tawājud is aimed to gain wajd by representing to one’s mind the bounties and evidences of God, and thinking of union (ittiḥād) and wishing for the practices of Muslim saints.
URBAN SUFISM: A CASE STUDY OF TASAWUF PRACTICES IN THE UICCI STUDENTS OF SULAIMANIYAH CIPUTAT
Authors: Falah Muhammad Akmal
Published: July 2020

The phenomenon of the emergence of a higher interest in studying religious knowledge with a spiritual path began to develop in society. This cannot be separated from the role of the tarekat in the midst of urban life. People in urban areas who study religious knowledge and learn about Sufism in urban areas are then better known as "urban Sufism". The existence of an institution that facilitates students who want to explore religious knowledge while learning Sufism, UICCI Islamic Boarding School branch Sulaimaiyah Ciputat, located in Ciputat, South Tangerang, is a place for Muslim students who want to study religious knowledge and also Sufism. Most students in this pesantren are students from various fields and majors from various universities which are dominated by UIN Jakarta students. This pesantren has its own privileges compared to several other pesantren around it, namely that they practice the teachings of Sufism with the Naqsyabandiyah order as its basic foundation.
Analysis of the Causes of Narcotics Recidivities in Class IIa Prisons in Bogor
Authors: Septiawan Yudha Nugraha
Published: July 2020

The risk can cause harm to someone, including people who have used narcotics. Drug abuse is a concern for many people today. Misuse of narcotics is a deviation of behavior or deeds that violate the law, and it is unfortunate if prisoners who are free to repeat the narcotics crime again. The problem that became the reference in this research is whether the factors that cause the repetition of narcotics crime, how the risk of repetition of narcotics crime, and how to overcome the narcotics crime repetition. The purpose of this study is to determine the factors, risks, and efforts in overcoming repetition of narcotics crime. This research was conducted using a qualitative approach by collecting data using interview, observation, and documentation methods. Data analysis is described in the form of sentence descriptions and analyzed qualitatively, then a conclusion is drawn. Based on the results of research and discussion, it is concluded: (1) Factors that influence the repetition of narcotics crime are internal factors and external factors. (2) The risk of repetition of narcotics crime is carried out in the level of risk classification. (3) Efforts to overcome the repetition of narcotics crime shall be carried out in a preventive and repressive manner. The advice given is maximizing rehabilitation activities carried out in Corrections Institutions and maximizing coaching programs in Corrections Institutions
Application of RUSLE integrated with GIS and remote sensing techniques to assess soil erosion in Anambra State, South-Eastern Nigeria
Authors: Ajibade Fidelis Odedishemi , Nwogwu Nathaniel Azubuike , Adelodun Bashir , Abdulkadir Taofeeq Sholagberu , Ajibade Temitope Fausat , Lasisi Kayode Hassan , Fadugba Olaolu George , Owolabi Titilayo Abimbola , Olajire Olabanji Olatona
Published: July 2020

Soil erosion and mass movement processes spread across Anambra State in Nigeria, therefore making management and conservation techniques expensive and difficult in execution across the entire state. This study employed the Revised Universal Soil Loss Equation (RUSLE) model with the integration of geographic information system (GIS) and remote sensing techniques to assess the risk of soil erosion and hotspots in the area. Remotely sensed data such as Landsat 8 imagery, Shuttle Radar Topography Mission (SRTM) imagery, Era-Interim coupled with world soil database were used as digital data sources for land use map, digital elevation model, rainfall and soil data, respectively, to generate the Universal Soil Loss Equation (USLE) parameters. The results indicated vulnerability levels in low, medium and high cover areas of 4,143.62 (91%), 332.29 (7%) and 84.06 (2%) km2, respectively, with a total soil loss between 0 and 181.237 ton/ha/yr (metric ton per hectare per year). This study revealed that high rainfall erosivity, steep and long slopes, and low vegetation cover were the main factors promoting soil loss in the area. Thus, the amount of soil loss in Anambra State is expected to increase with climate change and anthropogenic activities.
Monitoring point optimization in lake waters
Authors: Liu Gaoxuan , Ai Jiaoyan , Xu Jun , Zheng Jianwu , Yao Dongyi
Published: July 2020

In order to grasp the distribution of water quality index in lake water, taking Jinghu Lake of Guangxi University as the experimental object, an radial basis function (RBF) neural network was combined with a genetic algorithm on the basis of an unmanned ship to study the optimal selection of monitoring points. The single-objective and multi-objective optimization of water quality parameters were tested respectively and used to make the fitting distribution map. The results show that the genetic neural network has obvious advantages over the traditional isometric monitoring in the distribution error of water quality parameters, and the data reflected by the results are still accurate and effective at least six weeks after optimization. The results show that a genetic neural network can significantly improve the efficiency of water quality monitoring.
Early results of surgery for aortic valve disease in patients with severe left ventricular dysfunction
Authors: Babeshko S. , Samurganov Yu. , Shumkov D. , Barbukhatti K. , Porkhanov V.
Published: July 2020

Aim. This study aimed to analyse the early results of aortic valve replacement in patients with severe left ventricular dysfunction: i.e. a left ventricle ejection fraction (LVEF) ≤30%.Methods. This retrospective study included 145 adult patients with isolated aortic valve disease and LVEF ≤30% who underwent aortic valve replacement from 2005 to 2019 at our institution. Patients who required any concomitant or redo surgery were excluded from the study.Results. There were three perioperative deaths (in-hospital mortality, 2.1%) due to multiple organ failure syndrome (two patients) or acute heart failure (one patient). Postoperative heart failure was the prevailing non-lethal complication (73% of cases). Other complications occurred less frequently: nine patients (6.2%) had acute kidney injury (four of whom required hemodiafiltration), one patient (0.7%) suffered a stroke, six patients (4%) required chest re-exploration for bleeding and two patients (1.4%) experienced sternal infection of the surgical wound. Patient LVEF improved significantly from 22.6% ± 5.3% to 35.8% ± 11.0% postoperatively (a 37% mean increase; p = 0.02), and most patients (73%) were classified as New York Heart Association class I–II by the time of discharge.Conclusion. Our study showed excellent results of surgery for aortic valve disease in patients with severe left ventricular dysfunction. Postoperatively, there was a marked increase in LVEF and significant clinical improvement.
Received 1 May 2020. Revised 12 May 2020. Accepted 18 May 2020.
Funding: The study did not have sponsorship.
Conflict of interest: Authors declare no conflict of interest.
Author contributionsConception and design: S.S. Babeshko, K.O. Barbukhatti, V.A. PorkhanovData collection and analysis: S.S. Babeshko, D.I. ShumkovDrafting the article: S.S. Babeshko, Y.P. SamurganovStatistical analysis: S.S. Babeshko, D.I. ShumkovCritical revision of the article: S.S. Babeshko, Y.P. Samurganov, K.O. BarbukhattiFinal approval of the version to be published: S.S. Babeshko, Y.P. Samurganov, D.I. Shumkov, K.O. Barbukhatti, V.A. Porkhanov
Correlation Between BCL2 and Mcl1 Single Nucleotide Polymorphisms and Chemotherapy Response in Jordanian Patients with Colorectal Cancer
Authors: Mhaidat Nizar M. , Amawi Haneen , Alzoubi Karem H.
Published: July 2020

Background:

Colorectal cancer is one of the most common types of cancer worldwide and a
leading cause of death in Jordan. BCL-2 and MCL-1 are anti-apoptotic proteins that inhibit programmed
cell death and their over-expression has been shown to be associated with reduced sensitivity
to chemotherapy and poor survival in cancer patients.

Objective:

In the present study, three SNPs in the promoter region of antiapoptotic genes were investigated
in an effort to inspect the occurrences of SNPs (rs2279115, rs4987852) in the promoter region
of BCL2 and SNP (rs9803935) in the promoter region of MCL1 in Jordanian patients with CRC, and
investigate correlations between BCL2 and MCL1 SNPs and clinical outcomes.

Methods:

PCR-restriction fragment length polymorphism (RFLP)-based analysis was used for samples
genotyping.

Results:

The BCL2 rs2279115 and MCL1 rs9803935 SNPs showed significant distribution where mutant
and hetero genotypes are more prominent in CRC patients. Additionally, the rs2279115 genotypes
and alleles were associated with stages of disease, its recurrence and metastasis. The MCL1 rs9803935
genotypes were associated disease metastasis. However, for BCL2 rs4987852 SNP, there was no association
of genotypes or alleles with any of the disease variables.

Conclusion:

The BCL2 SNPs (rs2279115) and MCL1 SNP (rs9803935) present as important determinants
of the progress of CRC in Jordanian patients.
Long Term Prognostic Utility of Matrix Metalloproteinase-9 in Patients with Acute Coronary Syndrome - A Systematic Review
Authors: Das Anamika , George Melvin , Jha Durga , Goenka Luxitaa
Published: July 2020

Background:

Acute Coronary Syndrome (ACS) is the leading cause of morbidity and mortality
in developed countries. Numerous groups have explored single and multiple biomarker strategies
to identify diagnostic prognosticators of ACS, which will improve our ability to identify high-risk individuals.
Matrix Metalloproteinase (MMP-9) is one potential biomarker, which has been widely studied
in ACS. Recent reports have showed the prognostic utility of MMP-9, but due to inconsistent results,
it has not been possible to draw firm conclusions.

Objective:

This review aims to explore the ability of MMP-9 to predict long-term prognosis of ACS. To clarify this issue,
we conducted a literature review to provide a comprehensive assessment of MMP-9 levels in ACS patients.

Method:

We retrieved a total of 1501 articles from PubMed and Google Scholar. After thorough scrutiny, 12 original research articles were found fulfilling the inclusion exclusion criteria. MMP-9’s ability as a biomarker of prognostication post
ACS was reviewed. PRISMA guidelines were used for reporting.

Result:

The results revealed that MMP-9, apart from being an efficient diagnostic biomarker for ACS, helps in predicting
the future risk of ACS with disease outcome. Positive correlation was found between plasma MMP-9 and left ventricular
remodeling. A positive association was also found between cardiovascular death and higher MMP-9 levels.

Conclusion:

MMP-9 can be a potential prognostic marker for ACS and aid in identifying high risk patients for intensive
management during follow -up.
Cosmetic Fat Transplantation: A Review
Authors: Davis Sarah , Rizk Joseph , Gunton Jenny E.
Published: July 2020

Aim:

To review current techniques used in fat grafting to optimise graft
persistence and achieve optimal cosmetic outcomes.

Background:

Fat transplantation has been used extensively in the reconstruction and
cosmetic industry for many years. However, there is significant adipocyte loss and
reabsorption rates, leading to the loss of external cosmetic volume and the need for
repeat procedures. Adipocyte loss can occur at all four stages of transplantation and this
review discusses each of these methods with the aim being to optimise graft outcome.

Results:

Several new techniques have been discussed including liposuction techniques,
fat processing, and assisted fat grafting which show an improvement in adipocyte
survival, revasculisation and graft outcomes.

Conclusions:

There have been many improvements in fat grafting and the
implementation of these will optimise surgical outcomes but there are still strategies to
improve further. However, there is still a lack of standardised techniques and training.
More research is needed in the areas of fat processing and the use of additives to the fat
graft. More clinical research is needed in the fat placement technique, which has very
little published evidence and current techniques are mostly anecdotal by cosmetic
surgeons.
Synthesis and Molecular Simulation Studies of Mandelic Acid Peptidomimetic Derivatives as Aminopeptidase N Inhibitors
Authors: Chen Jiawei , Lv Qiaoli , Tu Guogang
Published: July 2020

Background:

The aminopeptidase N (APN) over-expressed in tumor cells plays a critical
role in angiogenesis which makes the development of APN inhibitors an attractive strategy for
cancer research.

Aims and Objectives:

It is clinically significant to develop potential APN inhibitors for cancer
treatment. The design, synthesis, biological evaluation and molecular simulation of mandelic acid
peptidomimetic derivatives as APN inhibitors are reported.

Materials and Methods:

Analysis of the binding mode of bestatin to APN led to the design and
synthesis of mandelic acid peptidomimetic derivatives. APN inhibitory activities in vitro were
evaluated by the spectrophotometric method. The binding mode of the target compounds with the
APN binding site was studied relying on docking studies, molecular dynamics simulation experiments
and binding energies calculation.

Results:

The structures of target compounds were confirmed by IR, 1H-NMR and MS. All compounds
exhibited a different range of inhibitory ability with IC50 values lying in the micromolar
level. The compound 9m was found to be most potent as compared to other target derivatives. The
molecular simulation revealed that ligand coordinating with the catalytic zinc ion is very important
for inhibitory activities.

Conclusion:

The compound 9m might represent a promising scaffold for the further development
of novel anti-cancer drugs.
Screening of Drug Efficacy of Rosmarinic Acid Derivatives as Aurora Kinase Inhibitors by Computer-Aided Drug Design Method
Authors: Sarkar Kaushik , Sarkar Subhajit , Das Rajesh Kumar
Published: July 2020

Background:

Aurora kinases (AKs) belong to serine/threonine kinase family, play a crucial role in regulating the
cell cycle. Therefore, AKs are the hopeful target for anticancer therapies and these finding have appreciated researchers to
rigorous hunting of small molecule aurora kinase inhibitors, not only for research articles but also use as therapeutic agent.

Objective:

The present study helps us to identify and screen best phytochemicals as potent inhibitors against AKs. These
potent inhibitors are coming from various substitution of rosmarinic acid (RA).

Methods:

In this paper, we choose different tested derivative compounds for designing anticancer
drugs by substituting various functional groups of standard drug RA. In silico studies were carried
out to appreciate better drug candidature of some of these derivative compounds. This study was
performed on 56 derived compounds of the standard RA. DFT study was conducted using the
UB3LYP/6-311++G(d,p) basis set to study HOMO-LUMO energies, dipole moments, using the
Gaussian16 suite. Some of the derived parameters, like ionization potential, electron affinity, softness-
hardness, chemical potential, and electrophilicity index were noted. A docking study was performed
with AKs inhibiting receptor using AutoDock 4.2. ADME prediction was made with the
preADMET web tool. Molecular descriptor properties were predicted with molinspiration and
OSIRIS property explorer.

Results:

Out of 56 derivatives, 11 have passed all the rules of drug candidature, to serve as best AKs inhibitor, in a theoretical
manner.

Conclusions:

This study should be supported a new proposal to explore future studies with these 11 compounds against cancer.
The Impact of Opioid Analgesics and the Pharmacogenomics of ABCB1 in Opioid Dependence and Pharmacotherapies: A Short Review
Authors: Parchure Akshay S. , Peng Yuan B.
Published: July 2020

Pain is extremely multifaceted in nature, with physical injury being just one of its causes. The most commonly prescribed therapeutic intervention for acute as well as chronic pain (postoperative or otherwise) is Opioids. Opioid analgesics act via the opioid receptors (G protein coupled), that are widely distributed in the central and peripheral nervous system as well as the gastrointestinal tract, producing pain relief. The opioid analgesics are divided into distinct categories depending on the receptor type and their potency. Three major types of receptors mediate analgesic effects, namely, mu (μ), delta (δ) and kappa (κ). These are also further subdivided into different subtypes depending on the duration and onset as rapid-onset, short-acting and long-acting. The neurobiology behind opioid analgesia involves the mesolimbic (midbrain) reward system. There is also increasing scientific evidence that plasma pharmacokinetics, along with the CNS distribution of opioids, is greatly influenced by the P-glycoprotein (P-gp) efflux transporter. The ABCB1 gene is responsible for coding P-gp hence it was postulated that variability in the ABCB1 gene could potentially play an important role in determining why there is interindividual variability towards opioids therapeutic interventions

Hence the primary purpose of this review was to compile and understand the research regarding the mechanisms of opioid actions and the effect of genetic variability (ABCB1 gene), on the P-gp transporters regarding their expression/function while also examining the opioid use, abuse and dependence and possibly coming up with some strategies to use pharmacogenomics as a potential tool for solving these issues
Efecto de la micorrización y el lombriabono sobre el crecimiento y desarrollo del Sacha inchi Plukenetia volubilis L.
Authors: Pérez Caro Luís Alejandro , Oviedo Zumaqué Luís Eliecer , Barrera Violeth José Luis
Published: July 2020

El sacha inchi Plukenetia volubilis es una Euphorbiaceae de importancia socioeconómica debido al alto valor nutricional de su semilla; siendo importante establecer estrategias agronómicas que incremente los rendimientos; por lo cual se evaluó el efecto de la micorrización y del lombriabono, en el crecimiento y desarrollo de la planta. La investigación se realizó en el corregimiento de Berástegui, municipio de Ciénaga de oro, Córdoba,bajo un diseño de bloques al azar con tres repeticiones y los tratamientos T1: Control, sin aplicación, T2: 100 gr/planta de Micorriza comercial (micorrizafer) y T3: 2 kg/planta con lombriabono. Los tratamientos se aplicaron a los 45 días después de siembra (DDS). Las evaluaciones se efectuaron de acuerdo al ciclo fenológico (crecimiento vegetativo y reproductivo) del cultivo, cuantificando la altura de planta y diámetro del tallo a los 52, 97 y 136 DDS, número de flores femeninas; número de flores fecundadas y número de flores masculinas 112, 128,144 y 168 DDS y el número de capsulas 128, 144, 168 y 176 DDS. Las variables evaluadas en plantas inoculadas con micorrizas fueron significativamente mayor (P<0,05) que cuando se fertilizó con lombriabono superándolo en altura (0,23 m), diámetro del tallo en (0,08 cm), número de flores femeninas (8 flores), número de flores fecundadas (38 flores) y número flores masculinas (18 flores). Se concluye, que la planta de Sacha inchi, es dependiente de la micorrización y responde significativamente a planes de fertilización cuando se incluye micorrizas.
Caracterización morfoagronómica de la colección de germoplasma de ají dulce (Capsicum spp.) del caribe colombiano
Authors: Correa-Álvarez Ender M. , León-Pacheco Rommel I. , Lobato-Ureche Miguel A. , García-Davila Mario A. , Muñoz-Perea Carlos G. , Aramendiz-Tatis Hermes
Published: July 2020

El ají dulce tipo topito es considerado una las principales hortalizas en la región Caribe de Colombia debido a su tradición productiva y consumo cotidiano en al menos seis de los siete departamentos de la costa atlántica. En este sentido el desarrollo de líneas investigación en mejoramiento genético que conduzcan a la obtención de cultivares de mayor productividad cobran gran relevancia. Por ello, con el fin de determinar la variabilidad morfológica y agronómica de la colección de germoplasma de ají dulce del Caribe colombiano y utilizarla en programas de mejoramiento genético, se evaluaron 45 descriptores (cualitativos y cuantitativos) de  Capsicum spp. en 125 accesiones procedentes de los siete departamentos de la región Caribe de colombia. Para ello, se empleó un diseño completamente al azar en nueve plantas. El análisis de los datos se realizó a través del método de clasificación de Ward utilizando la distancia de Gower. Los resultados revelan polimorfismo en 19 características cualitativas, con una variabilidad del 67,9%. El análisis mixto de los datos permitió separar las especies del género Capsicum de la colección en estudio; así mismo, la variabilidad fenotípica de la colección muestra potencial para su uso en programas de fitomejoramiento genético en caracteres de interés como calidad de fruto, arquitectura de planta y producción.