bluuebunny/crossref_metadata_2025 huggingface dataset:
Walenty Parczewski herbu Nałęcz, dowódca i powstaniec styczniowy
Authors: Kałużny Jędrzej Tomasz , Wochna Angelika
Published: November 2023

Celem publikowanego artykułu jest przybliżenie sylwetki Walentego Parczewskiego, powstańca styczniowego, dowódcy oddziału powstańczego walczącego na terenie gminy Uniejów w 1863 r. W tekście przedstawione zostało pochodzenie rodzinne i fakty z życia Parczewskiego. Ważną częścią publikowanej pracy jest również jego działalność powstańcza, w tym walki toczone na terenie dzisiejszej gminy Uniejów.
Pitfalls of Participatory Approaches
Authors: Czyżewski Marek
Published: November 2023

Over recent decades, “participation” has become one of the leading mottos of reform-oriented movements in such diverse fields as democracy, technology, finance, management, mass media, culture, social research methodology and, last but not least, social work. Before our eyes the “change of function” (in the terminology of Karl Mannheim) has taken place: what in the sixties and seventies was an incorporation of subversive and alternative tendencies, has been absorbed step by step in mainstream discourses on politics, economy, social science and the helping professions. The discursive dominance of participatory ideas can be manifested when they constitute a prominent message in recent handbooks in the fields mentioned above or provide apparently self-evident justifications in typical applied research projects. This trend needs to be reflected upon if we are not to succumb to the self-destructive potential of participatory approaches.
Utilización de reglas de asociación para determinar soluciones tecnológico-constructivas para el mejoramiento de la eficiencia energética en edificios de salud
Authors: Urteneche Emilia , Barbero Dante Andrés , Martini Irene
Published: November 2023

En el año 2022, en la Argentina, el consumo energético del parque edilicio construido de los Sectores Residencial y Comercial-Público superó el 34 % y una parte significativa de este consumo se debe a los requerimientos para climatización. A su vez, las demandas de climatización se ven afectadas por la eficiencia energética de la envolvente edilicia, ya que a través de esta se produce el intercambio de calor entre el interior del edificio y su entorno. Este trabajo presenta la aplicación de un método de minería de datos, las reglas de asociación, para descubrir las soluciones tecnológico-constructivas más representativas presentes en la envolvente edilicia, en este caso, correspondientes a edificios destinados a la salud (Sector Comercial-Público). Para ello, es necesario identificar las distintas soluciones tecnológico-constructivas presentes en la envolvente (muros, carpinterías y techos) en los distintos edificios. Con tales datos como entrada, el algoritmo produce como resultados conjuntos de combinaciones de elementos de la envolvente que aparecen asociadas frecuentemente. A partir de estos resultados, se espera mejorar la eficiencia energética de las envolventes más representativas a partir de sugerir medidas específicas para cada terna encontrada facilitando, así, su implementación a escala masiva.
Fornet-Betancourt, R. (2022). Modelos de teoría liberadora en la historia de la filosofía europea. Bogotá: Editorial Favila
Authors: Lavacude Jhon
Published: November 2023

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Zagotavljanje migracijskih koridorjev za prostoživeče živali na območju železniške infrastrukture
Authors: Petkovšek Samar Al Sayegh , Kotnik Klemen
Published: November 2023

Rail transport is considered to be more environmentally friendly, economical and socially acceptable than other types of land transport, especially when compared to road transport. However, it can adversely affect wildlife by creating barriers to their movement, commonly known as the “barrier effect”, and by directly increasing mortality due to collisions with trains. Therefore, it is crucial to plan and implement mitigating measures to ensure ecological connectivity and reduce wildlife mortality caused by rail traffic. The primary focus of such measures should be on preventing animals from accessing and lingering on railway tracks, since trains typically cannot avoid collisions. Measures that effectively reduce the number of collisions without exacerbating the barrier effect are particularly desirable. In this review article, we focused on measures that have been proposed or implemented in railway infrastructure. Additionally, we examine recent research exploring the feasibility of alternative mitigation measures, such as warning systems tested in Canada and Sweden. The second part of the paper presents a proposal for a protocol designed to ensure migration corridors and minimize barrier effects. The protocol was developed based on relevant literature and previous studies, as well as our own experience in planning and implementing monitoring measures to reduce wildlife mortality (with a focus on ungulates) on roads, highways and freeways. It also incorporates an analysis of collisions between wildlife and trains on the Slovenian railways network during a selected five-year period.
Políticas e Gestão na/da Educação Infantil
Authors: Barbosa Luciane Muniz Ribeiro , Monção Maria Aparecida Guedes , Correa Bianca Cristina
Published: November 2023

O Dossiê “Políticas e Gestão na Educação Infantil: Democracia e Direitos das crianças”  é composto por dez artigos, sendo sete de autoria de pesquisadoras brasileiras que atuam em diferentes instituições públicas (USP/São Paulo e Ribeirão Preto, UNICAMP, UNIFESP, UNIFAL/MG, UFMS/Naviraí e Pantanal e Fundação Carlos Chagas) e três por pesquisadores estrangeiros com reconhecida inserção nas temáticas propostas no dossiê, professores de universidades de diferentes continentes (University College London/England; The University of Waikato/New Zealand; Universidad de Chile/Chile). Tais pesquisadores abordam, no conjunto dos artigos, tanto a Política Pública de Educação Infantil em suas diferentes dimensões, quanto a Gestão do sistema de ensino e das unidades de creches e pré-escolas, tendo como eixo aglutinador os direitos das crianças e a perspectiva democrática. Trata-se de um conjunto de artigos que buscam evidenciar os desafios para a formulação e implementação de políticas e para a gestão na/da educação infantil para a promoção da justiça social, igualdade racial e democratização do acesso e permanência dos bebês e das crianças em distintos contextos. Partindo de diferentes matrizes teóricas, os textos promovem diálogos por meio da pluralidade de referenciais que fundamentam e favorecem a análise do cotidiano das instituições de educação infantil e da Gestão das redes de ensino pública, abarcando a dimensão estética, a formação de professores, os impasses e os avanços das políticas para a educação pública, democrática e de qualidade em creches e pré-escolas.
Vascularized omental tissue transfer for the treatment of lymphedema: a review
Authors: Skladman Rachel , Moritz William R. , Tenenbaum Elijah J. , Christensen Joani M. , Sacks Justin M.
Published: November 2023

Lymphedema is a debilitating disorder caused by impaired drainage of the lymphatic system. In the Western world, lymphedema most often arises secondary to the treatment of malignancy. Patients with lymphedema experience progressive swelling, pain, numbness, and tingling, and decreased quality of life. Those with persistent symptoms may be subject to chronic cellulitis. The advent of microsurgery has enabled clinicians to transplant donor lymph nodes and their blood supply from a healthy site to the affected area in a procedure known as vascularized lymph node transplant (VLNT). One donor region is the omentum. Vascularized omental lymph node transfer (VOLT) has been shown to decrease limb volume, circumference, and subjective symptoms of lymphedema. The immunologic properties of the omentum make it a particularly useful lymph node donor site for patients with lymphedema-related cellulitis. The omentum may be harvested laparoscopically, with robotic assistance, or through a small laparotomy incision. In this review, we describe the relevant anatomy and history of VOLT as well as operative techniques. The risks, benefits, and relevant outcome studies will be reviewed. Recent applications of robotic surgery to VOLT will be addressed.
Profil Petani Pembudidaya Talas (Araceae ) di Desa Karang Intan Kabupaten Banjar, Kalimantan Selatan
Authors: Mardiana Herlin , Kadarsah Anang , Agusliani Erma
Published: November 2023

This study aims to analyze the density and distribution of the taro plant and to obtain information about the knowledge of the local population on the cultivation technique of taro (Colocasia esculenta L. Shoot) in Karang Intan Village, Banjar Regency, South Kalimantan. Taro cultivators was carried out by interview method with 10% of respondents. The interview were made a comparison percentage and discussed descriptively. The results showed that the taro cultivators are dominated by women (56.25%) and the rest 43.75% are men. Respondents majority were from the age group 41-50 years (43.75%) and the lowest (12.5%) was from the age group 21-30 and 31-40 years. Farmers are the most occupied livelihood (75%) and the rest are fish farmers (25%). Taro cultivators in Karang Intan Village still apply simple cultivation techniques and local wisdom that are hereditary. Key words: Taro, farmer, knowledge
Disclosure of intimate partner violence while studying positive mental health in wheelchair users: ethical dilemmas
Authors: Babu Sonu S , Varma Ravi Prasad
Published: November 2023

This case study discusses the ethical dilemmas faced by the researchers when a woman with disability voluntarily disclosed her experience of intimate partner violence during an in-depth interview on positive mental health and resilience in wheelchair users. The interviewer's role as a researcher and public health professional raised dilemmas relating to the tenets of privacy, confidentiality and nonmaleficence. Professionals working with women with disability and similar vulnerable participants should anticipate such ethical challenges around violence and discrimination that such individuals face, and strive to resolve challenges based on basic ethical tenets within a context-informed approach.
Right to abortion of survivors of rape in India
Authors: Kamthan Manika , Akhtar Ruksana
Published: November 2023

The Medical Termination of Pregnancy (MTP) Amendment Act, 2021, contains some progressive changes. However, survivors of rape will continue to go through mental as well as physical trauma to secure an abortion. We argue that the MTP Amendment Act, 2021, fails to address the rights of rape survivors adequately.
Analisis Kinerja Keuangan Perusahaan BUMN Bidang Konstruksi Bangunan Yang Listed di Bursa Efek Indosesia Sebelum dan Selama Pandemi Covid-19
Authors: Sukardi
Published: November 2023

Abstract-- This study aims to determine the financial performance of state-owned companies in the building construction sector which were listed on the Indonesia Stock Exchange before and during the Covid-19 Pandemic. The analytical tool used is based on the Decree of the Minister of State-Owned Enterprises Number: Kep-100/Mbu/2002 Concerning the Soundness Rating of State-Owned Enterprises. The research data was taken from the financial reports of all SOEs in the building construction sector which were listed on the Indonesia Stock Exchange in 2018 and 2019 (before Covid-19) and 2020 and 2021 (during Covid-19). The results of the financial performance analysis of 4 (four) SOEs in the Building Construction Sector listed on the IDX show that the average financial performance before Covid-19 was better than during Covid-19.

Key words : Financial performance, BUMN, Covid-19

            

Abstrak— Penelitian ini  bertujuan untuk mengetahui kinerja keuangan perusahaan BUMN bidang konstruksi Bangunan yang listed di Bursa Efek Indonesia sebelum dan selama Pandemi Covid-19. Alat Analisis yang digunakan mendasarkan pada Keputusan Menteri Badan Usaha Milik Negara Nomor : Kep-100/Mbu/2002Tentang Penilaian Tingkat Kesehatan Badan Usaha Milik Negara. Data penelitian diambil dari laporan keuangan seluruh BUMN bidang Konstruksi bangunan yang listed di Bursa Efek Indonesia tahun 2018 dan 2019 ( sebelum Covid-19) serta 2020 dan 2021( Selama covid-19). Hasil analisis kinerja keuangan terhadap 4 (empat) BUMN Bidang Konstruksi Bangunan yang listed di BEI menunjukkan bahwa rata-rata kinerja keuangan sebelum covid-19 lebih baik di bandingkan selama covid-19.

 Kata kunci :  Kinerja keuangan, BUMN,  Covid-19
PERANCANGAN MOTION GRAPHIC SEBAGAI MEDIA INFORMASI DALAM E-BOOK "PENINGKATAN PRODUKTIVITAS LAHAN KERING MASAM"
Authors:   Teknologi Rekayasa Perangkat Lunak, Sekolah Vokasi IPB University, Kusuma Nur Zharifah Pradinda , Kharismatunnisaa Fiona ,   Teknologi Rekayasa Perangkat Lunak, Sekolah Vokasi IPB University, Fami Amata ,   Teknologi Rekayasa Perangkat Lunak, Sekolah Vokasi IPB University
Published: November 2023

"Inovasi teknologi pengelolaan lahan kering masam telah banyak diciptakan. Diantaranya yaitu teknologi pengayaan unsur P dan K, teknik pemberian kapur untuk mengatasi kemasaman tanah dan keracunan alumunium, teknologi konservasi tanah berupa sistem olah tanah konservasi, pemanfaatan mulsa dan konservasi secara vegetatif. Inovasi teknologi yang diciptakan perlu disosialisasikan kepada petani milenial, tetapi sosialisasi tersebut belum maksimal jika hanya mengandalkan penyuluhan secara langsung di lapangan. Hasil inovasi ini akan berpengaruh terhadap petani milenial jika informasi yang disampaikan dibuat dengan menarik. Oleh karena itu, peneliti menerapkan motion graphic dalam e-book “Peningkatan Produktivitas Lahan Kering Masam” sebagai media informasi yang menarik mengenai teknologi pengelolaan lahan kering masam. Terdapat tiga tahapan pada pembuatan motion graphic yang berjudul ""Peningkatan Produktivitas Lahan Kering Masam"" antara lain preparation, production, dan post production. Motion graphic tersebut berisi informasi mengenai penjelasan, sifat, penyebaran, serta inovasi lahan kering masam dan pemanfaatan teknik ICLM. Penelitian ini berkolaborasi dengan Balai Besar Pengkajian dan Pengembangan Teknologi Pertanian (BBP2TP) sehingga berhasil menciptakan motion graphic dalam e-book"
KARAKTERISASI MIKRORNA-15A TERENKAPSULASI LIPOSOM DENGAN KONJUGASI DNA APTAMER MYAPTAVIN-3064 SEBAGAI NOVEL TERAPI REMIELINISASI SEL OLIGODENDROSIT PADA SKIZOFRENIA
Authors:   Pendidikan Dokter, Fakultas Kedokteran,Universitas Islam Indonesia, Yogyakarta, Indrayani Tsaniya Ahda , Khoirunnisa Aulia ,   Pendidikan Dokter, Fakultas Kedokteran,Universitas Islam Indonesia, Yogyakarta, Aviciena Anindya ,   Pendidikan Dokter, Fakultas Kedokteran,Universitas Islam Indonesia, Yogyakarta
Published: November 2023

ABSTRAK Latar belakang: Skizofrenia merupakan penyakit yang menyerang sistem saraf pusat dan berdampak pada perilaku manusia. Skizofrenia dapat disebabkan karena penurunan mikroRNA (miRNA), transmisi sinyal, dan kerusakan pada struktur otak. Skizofrenia meningkatkan angka kematian di dunia sampai dengan 20%. Pengobatan yang ada sekarang memfokuskan pada pengaturan neurotransmiter pada area sinap neuron, namun metode pengobatan ini mempunyai efek samping berupa peningkatan berat badan dan efek hipersensitivitas terhadap dopamin. Tujuan: Tulisan ilmiah ini dibuat dengan tujuan untuk membuktikan potensi miRNA-15a sebagai agen pengobatan skizofrenia melalui remielinisasi sel oligodendrosit. Metode: Tulisan ilmiah ini dibuat menggunakan metode analisis literatur dari PubMed, ScienceDirect,and Springer. Hasil: MiRNA-15a akan dienkapsulasi dengan nanopartikel liposom aptamer myaptavin-3064 yang dikonjugasikan dengan transferin agar dapat melewati sawar darah otak (BBB). Kesimpulan: Berdasarkan teori yang didapatkan miRNA-15a dapat meningkatkan metabolisme dan siklus sel sehingga diharapkan dapat meningkatkan potensi sel oligodendrosit yang rusak untuk mengalami remielinisasi, sehingga bisa menjadi pengobatan baru untuk penderita skizofrenia.
Early Age- and Sex-Dependent Regulation of Astrocyte-Mediated Glutamatergic Synapse Elimination in the Rat Prefrontal Cortex: Setting an Organotypic Brain Slice Culture Investigating Tool
Authors: Vivi Eugenia , Seeholzer Lea R , Nagumanova Anastasia , Di Benedetto Barbara
Published: November 2023

Clinical and pre-clinical studies of neuropsychiatric (NP) disorders show altered astrocyte properties and synaptic networks. These are refined during early postnatal developmental (PND) stages. Thus, investigating early brain maturational trajectories is essential to understand NP disorders. However, animal experiments are highly time-/resource-consuming, thereby calling for alternative methodological approaches. The function of MEGF10 in astrocyte-mediated synapse elimination (pruning) is crucial to refine neuronal networks during development and adulthood. To investigate the impact of MEGF10 during PND in the rat prefrontal cortex (PFC) and its putative role in brain disorders, we established and validated an Organotypic Brain Slice Culture (OBSC) system.Using Western blot, we characterized the expression of MEGF10 and the synaptic markers synaptophysin and PSD95 in the cortex of developing pups. We then combined immunofluorescent-immunohistochemistry with Imaris-supported 3D-analysis to compare age- and sex-dependent astrocyte-mediated pruning within the PFC in pups and OBSCs. We thereby validated this system to investigate age-dependent astrocyte-mediated changes in pruning during PND. However, further optimizations are required to use OBSCs for revealing sex-dependent differences. In conclusion, OBSCs offer a valid alternative to study physiological astrocyte-mediated synaptic remodelling during PND and might be exploited to investigate pathomechanisms of brain disorders with aberrant synaptic development.
Safety of Floor Surfaces in Public Service Buildings: Portable Slip Testers
Authors: Sariisik Gencay , Çoşkun Gültekin
Published: November 2023

The occurrence rate of occupational accidents caused by slipping and falling is 50% worldwide. Determining the slip safety risk is necessary to minimize the accidents caused by slipping in pedestrian walking areas. By on-site testing, this study aims to determine the slip risks of floor coverings used in walking areas with many pedestrians in public service buildings (PSB). For this purpose, on-site measurements were performed in two environments and six locations in PSB using portable GMG 200 and pendulum testers operating according to DIN 51131 and TS EN 14231 standards. These tests were performed on four-floor coverings with polished surface treatment in PSB. Since the floor coverings measured have a polished surface, it can be seen that the dynamic friction coefficients (DCOF) values are very low, and the slip risks are high. By statistically analyzing the slip test data using the K-means method, a new safety classification was made according to the usage areas of floor coverings. To minimize the risk of slip safety, especially for students, patients, and employees in PSB, it is recommended to use floor coverings with high DCOF values and low slip risk.
Development of Cavitation Generator Mimicing Pistol Shrimp
Authors: Soyama Hitoshi , Tanaka Mayu , Takiguchi Takashi , Yamamoto Matsuo
Published: November 2023

Pistol shrimps generate cavitation bubbles. Cavitation impacts due to bubble collapses are harmful phenomena, as they cause severe damage to hydraulic machineries, such as pumps and valves. However, cavitation impacts can be utilized for mechanical surface treatment to improve the fatigue strength of metallic materials, which is called “cavitation peening”. Through conventional cavitation peening, a cavitation is generated by a submerged water jet, i.e., a cavitating jet or a pulsed laser. The fatigue strength of magnesium alloy when treated by the pulsed laser is larger than that of the jet. In order to drastically increase the processing efficiency of cavitation peening, the mechanism of pistol shrimp (specifically when used to create a cavitation bubble), i.e., alpheus randalli, was quantitatively investigated. It was found that a pulsed water jet generates a cavitation bubble when a shrimp snaps its claws. Furthermore, two types of cavitation generators were developed, namely, one that uses a pulsed laser and one that uses a piezo actuator, and this was achieved by mimicing a pistol shrimp.
Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease
Authors: Joshi Sameer M , Wilson Thomas C , LI Zibo , Preshlock Sean , Gómez-Vallejo Vanessa , Gouverneur Véronique , Llop Jordi , Arsequell Gemma
Published: November 2023

The small-molecule iododiflunisal (IDIF) is a transthyretin (TTR) tetramer stabilizer and acts as a chaperone of the TTR-Amyloid beta interaction. Oral administration of IDIF improves Alzheimer’s Disease (AD)-like pathology in mice, although mechanism of action and pharmacokinetics remain unknown. Radiolabeling IDIF with positron or gamma emitters may aid in the in vivo evaluation of IDIF using non-invasive nuclear imaging techniques. In this work, we report isotopic exchange reaction to obtain IDIF radiolabeled with 18F. [19F/ 18F]exchange reaction over IDIF in dimethylsulfoxide at 160 °C resulted in the formation of [18F]IDIF in 7±3% radiochemical yield in a 20 minutes reaction time, with a final radiochemical purity of >99%. Biodistribution studies after intravenous administration of [18F]IDIF in wild-type mice using positron emission tomography (PET) imaging showed capacity to cross the blood-brain barrier (ca. 1% of injected dose per gram of tissue in the brain at t>10 min post administration), rapid accumulation in the liver, long circulation time and progressive elimination via urine. Our results open opportunities for future studies in larger animal species or human subjects.
Events as Elements of Physical Observation
Authors: Müller Gerhard
Published: November 2023

It is argued that all physical knowledge ultimately stems from observation and that the simplest possible observation is that an event has happened at a certain space-time location . Considering historic experiments, which had been groundbreaking in the evolution of our modern ideas of matter on the atomic, nuclear and elementary particle scales, it is shown that such experiments produce as outputs macroscopically observable events which represent binary decisions with regard to simple alternatives and which accumulate in the course of time into spatio-temporal patterns whose forms allow decisions to be taken concerning conceivable alternatives of explanation. Working towards elucidating the physical and information-theoretic characteristics of those elementary pieces of information we arrive at the conclusion that - unlike the events of relativity which are mere 4-tuples of spacetime coordinates - the events of observation are pieces of information endowed with the properties of physical action, spacetime extension, and Lorentz invariance. Another important aspect is that such events are produced at the expense of irreversibly dissipating energy which can be stated in Landauer diction in the form that more energy needs to be spent in the erasure of events than had previously been invested in their initiation.
A Variational Approach to Excited Fermions on Kinks
Authors: Weigel Herbert , Saadatmand Danial
Published: November 2023

We study the back-reaction of fermion fields on the kink solution in one space and one time dimension. We employ a variational procedure to determine an upper limit for the minimum of the total energy. This energy has three contributions: the classical kink energy, the energy of valence fermions and the fermion vacuum polarization energy. The latter arises from the interaction of the kink with the Dirac sea and is required for consistency of the semi-classical expansion for the fermions. Earlier studies only considered the valence part and observed a substantial back-reaction. This was reflected by a sizable distortion of the kink profile. We find that this distortion is strongly mitigated when the Dirac sea is properly accounted for. As a result the back-reaction merely produces a slight squeeze or stretch of the kink profile.
From Hemp Waste to Bioactive Nanofiber Composites: Deep Eutectic Solvents and Electrospinning in Upcycling Endeavors
Authors: Mouro Cláudia , Gomes Ana P. , Gouveia Isabel C.
Published: November 2023

Natural fibers have attracted increasing interest as an alternative to produce environmentally friendly and sustainable materials. Particularly, hemp fibers have revealed to be widely used in various industrial applications due to their extremely unique properties. However, hemp can generate a large amount of agro-waste, and results in an attractive source of biopolymers for the development of low-cost materials in alternative to the raw materials and conventional petroleum-based plastics. In addition, deep eutectic solvents (DESs), a new type of truly green solvents, have been tested to remove gums, lignin, and other non-cellulosic components from hemp fibers. Reusing these components dissolved into the DESs to fabricate new materials directly by electrospinning is a very attractive but still unexplored endeavor. Thus, this innovative research to venture new upcycling pathways is focused on the fabrication of composite nanofibers by electrospinning of a gel-based blend of Poly(vinyl alcohol) (PVA) and hemp agro-waste (HW) dissolved into choline chloride (ChCl) : Glycerol (1:2) and ChCl : Urea (1:2) DES mixtures. The results obtained revealed that the produced nanofibers displayed uniform appearance with diameters ranging from 257.72 ± 65.63 nm to 380.78 ± 133.98 nm. In addition, the mechanical properties of the electro-spun composite nanofibers produced from the gel-based blends of HW dissolved in DESs and PVA (HW-DESs_PVA) were found to be superior, resulting in an enhanced tensile strength and Young’s modulus. Furthermore, the incorporation of HW into the nanofibers was able to provide bioactive antioxidant and antibacterial properties.
Overall, this study demonstrated a promising, more sustainable, and eco-friendly way to produce electrospun composite nanofibers using HW in a circular economy perspective.
Uptake and Cellular Effects of Polymethylmethacrylate on Human Cell Lines
Authors: Braun Arthur , Seitz Harald
Published: November 2023

Both the use of plastic and its decomposition products lead to the distribution of plastic all over the earth and finally to the uptake by all kind of living beings including humans. Still, it is widely unknown what risks harbor the widespread uptake of plastics for human health, espe-cially regarding contributing factors like size, shape and surface composition. We assessed the uptake of polymethylmethacrylate (PMMA)-nano- and microbeads for HEK293-, A549- and MRC5 cells. Via confocal microscopy, we localized multiple PMMA-beads inside the cytosol of cells. Uptake of PMMA-beads did not alter cell growth and cell division, implying no short-term toxicity towards human cells. Further, we used a cAMP response element binding protein (CREB)-mediated reporter assay to assess whether internalized PMMA-nanobeads alter cell-signaling pathways. In contrast to the in vitro transcription, where the addition of PMMA-nanobeads abolished the transcription, no changes regarding CREB-mediated cell sig-naling are given in HEK293-cells. Our data led to the assumption that PMMA-nano-and mi-crobeads are internalized via endocytosis and end up as lysosomes within the cells cytosol. Therefore, we concluded differences regarding the surface composition of the PMMA-nanobeads mainly affect its potential to alter cell signaling. These findings emphasize the key role the sur-face composition plays regarding microplastic and its risks for human health.
Ecotoxicological Impact of Bioplastics Biodegradation: A Comprehensive Review
Authors: Ali Shakir , Isha Isha , Chang Young-Cheol
Published: November 2023

The emergence of bioplastics presents a promising solution to the environmental impact of the plastics industry. Biodegradable plastics are engineered to degrade in aquatic or soil environments. Biodegradable bioplastics can degrade in these conditions, according to sustainability standards, and have a low environmental impact. However, not all bioplastics are completely biodegradable, and some, like petrochemical-based plastics, may contribute to plastic pollution. In this comprehensive review, we identify the biodegradability of significant bioplastics, including polyhydroxyalkanoates (PHA), poly(lactic acid) (PLA), poly(butylene succinate) (PBS), and PBS-co-adipate (PBSA) in different environmental conditions given in the literature. Microbe-based bioplastics made from renewable materials like microalgae provide a sustainable alternative due to their high biodegradability compared to other bioplastics. However, we recognize concerns regarding the ecotoxicological impact of these alternatives on soil and aquatic organisms and recommend future research to observe the ecotoxicological behavior of biodegradation by-products.
Hospitalization and Mortality in Children Due to COVID-19. A Single Center Retrospective Study from Brazil
Authors: Pereira de Godoy Ana Carolina , Bulgarelli Bestetti Reinaldo
Published: November 2023

Background: COVID-19 is currently one of the most important medical challenges as it affects the entire population with children being infected as easily as adults. Objective: The study evaluated the mortality of under 17-year-olds and compare the frequency with that of adults in a cohort of 8986 COVID-19 positive patients hospitalized in a single care center. Design: retrospective clinical trial, all hospitalizations of COVID-19 positive patients as diagnosed by RT-qPCR were analyzed by revisiting their medical records. Setting: 8986 COVID-19 positive patients hospitalized in a Hospital de Base and the Infant and Maternal Hospital of São Jose do Rio Preto, SP, Brazil (HB/HCM) being these totals of 383 COVID-19 positive under 17-patients. Patients: patients COVID-19 positive under 17-year-olds were grouped by age and evaluated by analyzing their medical records. They were categorized as Group I, children, and adolescents under 19 years old and Group II, adults over 19 years. Results: Overall mortality in under 19-year-olds was 12 deaths, that is, 3.13% of the patients in this age group and 0.55% of the overall mortality from COVID-19. Mortality in the group of adults was 2197 equivalent to 24.45% of the hospitalized adults and 99.45% of overall deaths. Mortality was significantly higher for adults than for under 19-year olds (p-value < 0.0001). Regarding the different ages of children and adolescents, the number of deaths of under 1-year olds was 2/123 (1.62%), of 1-4 years it was 4/95 (2.11%), of 5-9 years it was 1/47 (2.13%), of 10-14 years it was 1/40 (2.5%) and of 15-19 years it was 4/78 (5.13%). There were no statistical differences between the different age groups ( p-value = 0.3). Conclusion: Mortality from COVID-19 in children and adolescents was lower than in adults and generally associated with other comorbidities with the main association being with heart disease.
Circulating Synthetic SARS-CoV-2 Spike Proteins Possibly Contribute to a Transient ACE2 Dysfunction Leading to Rare Cases of Myocarditis after COVID-19 mRNA Vaccination
Authors: Devaux Christian A. , Colson Philippe , Raoult Didier , Camoin-Jau Laurence
Published: November 2023

Myocarditis has been recognized as a possible rare complication of COVID-19 mRNA vaccination. It concerns between one and five vaccinated people per 100,000 in the general population, with increased incidence in adolescent and young adult men. Most often, cases of myocarditis have been reported in the days following the second dose of vaccine mainly in younger male patients. This rare complication of vaccination usually resolves within days or weeks. However, the pathophysiological events responsible for the increase in frequency of myocarditis after COVID-19 vaccination remain unclear. Several recent reports have highlighted that free spike proteins circulating in the blood of patients at high levels appear to play a major role in myocarditis. Here, we review the most relevant data that partly lift the veil on the molecular mechanisms of the induction of myocarditis following mRNA-based COVID-19 vaccination. We hypothesize that a mechanism of molecular mimicry of the viral spike triggers transient dysregulation of angiotensin-converting enzyme 2, leading to increased soluble angiotensin II binding to the transmembrane receptor angiotensin II type I receptor, similar to what is observed during SARS-CoV-2 infection. We suggest to standardize management of suspected cases of mRNA-based COVID-19 vaccine-induced myocarditis, including angiotensin II and spike antigenemia monitoring.
3D Printing Methods for Bioceramic-Based Scaffold Fabrication for Craniomaxillofacial Bone Tissue Engineering
Authors: Sheikh Zeeshan , Nayak Vasudev Vivekanand , Daood Umer , Kaur Anupreet , Moussa Hanan , Canteenwala Abbas , Michaud Pierre-Luc , Balderrama Ísis de Fátima , Sousa Edisa de Oliveira , Tovar Nick , Torroni Andrea , Glogauer Michael , Talib Huzefa , Coelho Paulo G , Witek Lukasz
Published: November 2023

3D Printing (3DP) technology has revolutionized the field of the use of bioceramics for maxillofacial and periodontal applications, offering unprecedented control over the shape, size, and structure of bioceramic implants. In addition, bioceramics have become attractive materials for these applications due to their biocompatibility, biostability, and favorable mechanical properties. However, despite their advantages, bioceramic implants are still associated with inferior biological performance issues after implantation, such as slow osseointegration, inadequate tissue response, and increased risk of implant failure. To address these challenges, researchers have been developing strategies to improve the biological performance of 3D printed bioceramic implants. The purpose of this review is to provide an overview of 3DP techniques and strategies for bioceramic materials designed for bone regeneration. The review also addresses the use and incorporation of active biomolecules in 3D printed bioceramic constructs to stimulate bone regeneration. By controlling the surface roughness, and chemical composition of the implant, the construct can be tailored to promote osseointegration and reduce the risk of adverse tissue reactions. Additionally, growth factors, such as bone morphogenic proteins (rhBMP-2) and pharmacologic agent (dipyridamole), can be incorporated to promote the growth of new bone tissue. Incorporating porosity into bioceramic constructs can improve bone tissue formation and the overall biological response of the implant. As such, by employing surface modification, combining with other materials, and incorporation of 3DP workflow can lead to better patient healing outcomes.
Approach of Trajectory Generation Based on Waypoint Information for a Highly Automated Vehicle
Authors: Sviatov Kirill , Rubtsov Ivan , Filippov Aleksey , Romanov Anton
Published: November 2023

The development and use of highly automated vehicles (HAV) in agriculture is a highly important task because of the lack of machine drivers and unsatisfactory level of their qualifications, reducing the impact of harmful factors on employees of agricultural enterprises. HAVs allow to avoid these problems: increase productivity and the efficiency of seasonal use of equipment, and reduce the impact of harmful factors on people. Modern HAVs in agriculture are based on the following methods: parallel driving according to geo coordinates without automatic turning and without obstacles tracking, and on technical vision without the use of a geographic information system (for example Cognitive AgroPilot) and a digital field map, which makes it impossible to generate the optimal path around the field.
SkinLesNet: Classification of Skin Lesions Using a Multi-Layer Deep Convolutional Neural Network in Dermoscopy Images
Authors: Azeem Muhammad , Kiani Kaveh , Mansouri Taha
Published: November 2023

Skin cancer is one of the widespread diseases that typically develop on the skin due to continuous exposure to sunlight. Although cancer can appear on any part of the human body, skin cancer reports account for over half of all cancer occurrences worldwide. There are substantial obstacles to the precise diagnosis and classification of skin lesions because of the morphological variety and indistinguishable characteristics across skin malignancies. Recently, Deep Learning models have been used in the field of image-based lesion diagnosis, and it has demonstrated diagnostic efficiency on par with that of dermatologists. To increase classification efficiency and accuracy for skin lesions, a cutting-edge multi-layer deep Convolutional Neural Network (CNN) termed SkinLesNet has been built in this study. The ResNetV50 and VGG16 models have been carefully compared to review the performance of the proposed model. The dataset used in this study, PAD-UFES-20, contains 1314 samples in total and includes three common forms of skin lesions. The proposed approach, SkinLesNet, significantly outperforms the well-known compared models in the given conditions
Expression of Elafin and CD200 as Immune Checkpoint Molecules Involved in Celiac Disease
Authors: Ponce-de-León Candelaria , Lorite Pedro , López-Casado Miguel Ángel , Mora Pablo , Palomeque Teresa , Torres María Isabel
Published: November 2023

(1) Background: We comprehensively evaluated the expression of therapeutically targetable immune checkpoint molecules on celiac disease. We have focused on the alteration of the CD200/CD200R pathway and Elafin expression in celiac disease and discussed their roles in regulating the immune response. There are limited data related to the expression or function of these molecules in celiac disease. This finding could significantly contribute to the understanding of the clinical manifestation of celiac disease; (2) Methods: CD200, CD200R and Elafin distribution was determined by ELISA and immunohistochemistry analyses in serum and biopsies of CD patients. Analyses of Th1 and Th17 cytokines were determined. PCR amplification of a fragment of the PI3 gene was carried out using genomic DNA isolated from whole blood samples of the study subjects. Different aliquots of the PCR reaction product were subjected to RFLP analysis for SNP genotyping and detection; (3) Results: We characterized the expression and function of the CD200–CD200R axis and PI3 in celiac disease. A significantly higher level of soluble CD200, CD200R and lower expression of PI3 in serum of CD patients was observed compared to healthy controls. Consistent with our results, CD200 expression is regulated by IFN-gamma. Interaction of CD200/CD200R leads to production of type Th1 and Th17 cytokines. Regarding the PI3 genotype, the CT genotype proportion SNP rs1733103 and the GG genotype SNP rs41282752, were predominant in CD patients. SNP rs1733103 showed a significant association between the SNP variables and CD; (4) Conclusions: In celiac disease the immune checkpoint is compromised or dysregulated, which can contribute to inflammation and the autoimmunity process. The study of these checkpoint points will led to the development of targeted therapies aimed at restoring immunological balance in CD. Specific coding regions of the PI3 gene splice variants predispose the Elafin protein, both at the transcriptional and post-translational levels, to modify its expression and function, resulting in reduced differential functional protein levels in patients with active celiac disease.
Hand-Held Echocardiography by Advanced Practice Providers in Patients with Congestive Heart Failure
Authors: Tagle-Cornell Maria-Cecilia , Novais Barbara S. , Wen Songnan , Shipman Justin , Mandale Deepa , Flom Drew , Sahnan Sandeep , Kriz Lindsey , Alland Michelle , Bird Christen , Naqvi Tasneem Z.
Published: November 2023

Objectives: Evaluate hand-held echocardiography (HHE) performed and interpreted by trained Advanced Practice Providers (APPs) on hospitalized CHF patients for image quality and interpretation, by comparing against expert echocardiographer and SE findings.
Background: Congestive heart failure (CHF) is associated with increased hospital admissions and mortality. While standard echocardiogram (SE) is the gold standard for cardiac assessment, it is not readily available. Hospitalized CHF patients require rapid assessment for expedited treatment.
Methods: Over 6 months, five trained APPs performed HHE on hospitalized CHF patients and interpreted: a) Left ventricular (LV) size, b) LV ejection fraction (LVEF), and c) right atrial pressure (RAP). The study echocardiographer reviewed and blindly interpreted HHE images and compared with APPs and SE findings. Kappa-statistics determined the degree of agreement between APPs and study echocardiographer interpretation of HHE images and SE.
Results: 80 CHF patients [age 73±14 years, 58% males; LVEF (by SE) 45±19%; 36.3% body mass indexes ≥30 kg/m2] were enrolled. HHE interpretation by APPs had good agreement for LVEF (kappa 0.79) with study echocardiographer and SE (kappa 0.74), and good agreement for RAP (kappa 0.67) with study echocardiographer. Correlation between absolute LVEF interpretation by study echocardiographer on HHE and SE was r=0.88 (p<0.0001).
Conclusions: Trained APPs obtained diagnostic-quality HHE images and interpreted LV function and RAP in CHF patients, with good agreement with the study echocardiographer. LVEF by HHE correlated with LVEF by SE. Our study suggests trained APPs can use HHE to evaluate LVEF and RAP in CHF patients leading to expedited and optimized treatment.
DETERMINAN POTENSI KEBANGKRUTAN PERUSAHAAN PADA MASA PANDEMI COVID-19
Authors: Rinofah Risal
Published: November 2023

The impact of the COVID-19 pandemic has a real and broad impact on all industries in Indonesia, which has the potential to increase the level of corporate bankruptcy (financial distress). This study aims to examine the effect of financial ratios on financial distress conditions in various industrial sub-sectors on the Indonesia Stock Exchange during the pandemic and before the pandemic. The study begins with the creation of a financial distress prediction model using the Logistics Regression Model with the input of financial and macroeconomic ratio data during 2016 – 2020. The financial distress prediction model will be used to measure the level of financial distress during the Pandemic and Pre-Pandemic Periods. Empirical testing shows that the pandemic affects the ability of financial ratios to predict the bankruptcy. In the pre-pandemic only debt ratio and sales growth were significant in predicting bankruptcy, but during the pandemic cash flow was also could predict the bankruptcy. During the pandemic, sales growth became the most important because it was the aspect most affected by the restrictions on consumer social and economic activities.
PENGUATAN KARAKTER KEMANDIRIAN MELALUI PERKULIAHAN KEPRAMUKAAN SEBAGAI UPAYA UNTUK MENINGKATKAN MUTU LULUSAN
Authors: Sumardjoko Bambang , Prasetyo Agus
Published: November 2023

The purpose of this research, first, is to identify the implementation of scouting lectures. The second describes the response of students during the scouting lectures. Third, describe the response of alumni and stakeholders regarding scouting courses. Fourth, produce a draft model of character strengthening through scouting lectures for PPKn students as an effort to improve the quality of graduates. This development research was carried out in stages. In the first stage, a qualitative descriptive approach was used. Data were obtained through in-depth interviews, focus group discussion, observations, literature reviews and archival recording. Sources of data come from scouting course supervisors, study program lecturers, alumni, and students taking scouting courses and stakeholders. Data validation is done through triangulation of sources and methods. Data analysis using interactive model. The results of the study concluded, first, that the implementation of scouting lectures at the department of PPKn FKIP UMS was held in semesters I, II, and IV. Second, students feel the many benefits of attending scouting lectures, especially those related to character building as prospective civics teachers. Third, alumni and stakeholders stated that the existence of scouting courses supports the quality of graduates, including to answer the challenges of the independent curriculum. Fourth, there is a draft model for strengthening student character through scouting lectures as an effort to improve the quality of graduates of the department PPKn FKIP UMS.
IMPLEMENTASI ETIKA MORAL MAHASISWA MELALUI MATA KULIAH PROTEKSI RADIASI SEBAGAI UPAYA PENANGANAN RADIASI NUKLIR
Authors: Lestari Ira Dwi , Ediyono Suryo
Published: November 2023

Moral ethics students has important role in the future of the nation. Students as agents of change need to have humane character and behavior and respect for others. Nuclear, the new renewable energy has radiation that harmful to humans. Knowledge is needed regarding efforts to maintain nuclear radiation so nuclear is no longer a threat. This study aimed to examine the application of student moral ethics against the threat of nuclear radiation through radiation protection learning. This research was conducted using the qualitative method with data collection attempt indirectly through literature study. Awareness of radiation protection is necessary for the operation of nuclear reactors to maintain human safety. Reactor nuclear operations should be organized in accordance with applicable regulations while prioritizing humanity.
Kaynak Temelli Bilgi Teknolojilerinin Dijital Muhasebe Okuryazarlığı Üzerine Etkisi
Authors: ÖZBEK Ali
Published: November 2023

Amaç: Bu çalışmanın amacı kaynak temelli bilgi teknolojilerinin muhasebe meslek mensuplarının dijital muhasebe okuryazarlığı üzerindeki etkisinin değerlendirilmesini sağlamaktır.

Tasarım/Yöntem: Çalışmada tesadüfi olmayan yöntemlerden kolayda örnekleme yöntemi kullanılarak 572 muhasebe meslek mensubu üzerinde anket uygulaması yapılmıştır. Elde edilen veriler SPSS 22 programıyla analiz edilmiştir.

Bulgular: Çalışma sonucunda kaynak temelli bilgi teknolojilerinin dijital muhasebe okuryazarlığı üzerinde (β:0.205; p