bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational Prediction of RNA–RNA Interactions between Small RNA Tracks from Betacoronavirus Nonstructural Protein 3 and Neurotrophin Genes during Infection of an Epithelial Lung Cancer Cell Line: Potential Role of Novel Small Regulatory RNA
Authors: Rojas-Cruz Alexis Felipe , Bermúdez-Santana Clara Isabel
Published: July 2023

Whether RNA–RNA interactions of cytoplasmic RNA viruses, such as Betacoronavirus, might end in the biogenesis of putative virus-derived small RNAs as miRNA-like molecules has been controversial. Even more, whether RNA–RNA interactions of wild animal viruses may act as virus-derived small RNAs is unknown. Here, we address these issues in four ways. First, we use conserved RNA structures undergoing negative selection in the genomes of SARS-CoV, MERS-CoV, and SARS-CoV-2 circulating in different bat species, intermediate animals, and human hosts. Second, a systematic literature review was conducted to identify Betacoronavirus-targeting hsa-miRNAs involved in lung cell infection. Third, we employed sophisticated long-range RNA–RNA interactions to refine the seed sequence homology of hsa-miRNAs with conserved RNA structures. Fourth, we used high-throughput RNA sequencing of a Betacoronavirus-infected epithelial lung cancer cell line (Calu-3) to validate the results. We proposed nine potential virus-derived small RNAs: two vsRNAs in SARS-CoV (Bats: SB-vsRNA-ORF1a-3p; SB-vsRNA-S-5p), one vsRNA in MERS-CoV (Bats: MB-vsRNA-ORF1b-3p), and six vsRNAs in SARS-CoV-2 (Bats: S2B-vsRNA-ORF1a-5p; intermediate animals: S2I-vsRNA-ORF1a-5p; and humans: S2H-vsRNA-ORF1a-5p, S2H-vsRNA-ORF1a-3p, S2H-vsRNA-ORF1b-3p, S2H-vsRNA-ORF3a-3p), mainly encoded by nonstructural protein 3. Notably, Betacoronavirus-derived small RNAs targeted 74 differentially expressed genes in infected human cells, of which 55 upregulate the molecular mechanisms underlying acute respiratory distress syndrome (ARDS), and the 19 downregulated genes might be implicated in neurotrophin signaling impairment. These results reveal a novel small RNA-based regulatory mechanism involved in neuropathogenesis that must be further studied to validate its therapeutic use.
Comparative Transcriptome Profiling of mRNA and lncRNA of Mouse Spleens Inoculated with the Group ACYW135 Meningococcal Polysaccharide Vaccine
Authors: Zhu Nan , Hu Liping , Hu Wenlong , Li Qiang , Mao Haiguang , Wang Mengting , Ke Zhijian , Qi Lili , Wang Jinbo
Published: July 2023

The Group ACYW135 meningococcal polysaccharide vaccine (MPV-ACYW135) is a classical common vaccine used to prevent Neisseria meningitidis serogroups A, C, Y, and W135, but studies on the vaccine at the transcriptional level are still limited. In the present study, mRNAs and lncRNAs related to immunity were screened from the spleens of mice inoculated with MPV-ACYW135 and compared with the control group to identify differentially expressed mRNAs and lncRNAs in the immune response. The result revealed 34375 lncRNAs and 41321 mRNAs, including 405 differentially expressed (DE) lncRNAs and 52 DE mRNAs between the MPV group and the control group. Results of GO and KEGG enrichment analysis turned out that the main pathways related to the immunity of target genes of those DE mRNAs and DE lncRNAs were largely associated with positive regulation of T cell activation, CD8-positive immunoglobulin production in mucosal tissue, alpha-beta T cell proliferation, negative regulation of CD4-positive, and negative regulation of interleukin-17 production, suggesting that the antigens of MPV-ACYW135 capsular polysaccharide might activate T cell related immune reaction in the vaccine inoculation. In addition, it was noted that Bach2 (BTB and CNC homolog 2), the target gene of lncRNA MSTRG.17645, was involved in the regulation of immune response in MPV-ACYW135 vaccination. This study provided a preliminary catalog of both mRNAs and lncRNAs associated with the proliferation and differentiation of body immune cells, which was worthy of further research to enhance the understanding of the biological immune process regulated by MPV-ACYW135.
A Two-Stage Model for Data-Driven Leakage Detection and Localization in Water Distribution Networks
Authors: Tyagi Vineet , Pandey Prerna , Jain Shashi , Ramachandran Parthasarathy
Published: July 2023

Water utilities face the challenge of reducing water losses by promptly detecting, localizing, and repairing leaks during their operational stage. To address this challenge, utilities are exploring alternative approaches to detect leaks with high accuracy in a timely manner, while minimizing environmental and economic consequences. This research proposes a two-stage model that relies on data analysis to predict leak incidents and their specific locations in water distribution networks (WDNs). By leveraging pressure and flow rate data collected from multiple points in the network, the model first calculates prediction errors in pressure heads. Subsequently, statistical measures applied to these error distributions are used to classify the occurrence and location of leaks. The suggested approach is both cost-effective and easily deployable. Through simulation-based case studies conducted on various benchmark networks, the efficacy of the proposed model is demonstrated. The results show that the model effectively predicts leak occurrences and their respective locations. However, it should be noted that as the network size increases, the model’s performance diminishes, resulting in reduced accuracy. Later, the accuracy of leak prediction has been evaluated by examining its sensitivity to varying numbers of sensors and different levels of noise.
Water Use in Australian Irrigated Agriculture—Sentiments of Twitter Users
Authors: Shrestha Arjina , Simmons Aaron T. , Roth Guy
Published: July 2023

The objective of this research was to examine consumer perceptions of water use in key Australian irrigated agriculture industries. Twitter data (‘Tweets’) from 2018 to 2022 related to water use/water footprints by/of the cotton, rice, and dairy industries were analyzed. The results revealed a higher prevalence of negative sentiments towards water use in Australian irrigated dairy, cotton, and rice industries compared to positive sentiments. The cotton industry received the most criticism. Our analysis showed that although the term “water footprint” was not widely used, the volume of water required for the production of irrigated cotton, dairy, and rice, or products derived from these commodities, is being circulated in tweets. However, the study also highlighted the presence of highly variable, incorrect, or outdated water footprint data in these tweets, indicating the unreliability of Twitter as an information source for consumers seeking to make sustainable consumption choices. This research offers valuable insights into consumer sentiments, benefiting stakeholders and policymakers in addressing public concerns and misinformation in the Australian irrigated agriculture sector.
Monitoring of Contamination of the Warta River in Poznan by Non-Steroidal Anti-Inflammatory Drugs and Antibiotics
Authors: Antos Joanna , Zembrzuska Joanna , Jeż-Walkowiak Joanna , Makała Aleksandra , Ginter-Kramarczyk Dobrochna , Kruszelnicka Izabela , Uwimpaye Fasilate
Published: July 2023

The pharmaceutical active compounds: non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, hormones, as well as detergents and pesticides that help improve human life are considered a source of water contamination. The amount of pharmaceutical active compounds in the environment is constantly increasing due to their widespread use by humans. Medicines sales in Poland are very high and rank sixth among European countries; moreover, sales are growing dynamically. Analysis of water samples from Warta River made it possible to study the dependence of NSAIDs, analgesics, and antibiotics concentrations in water due to season, month, and pandemic time. Analytes from the surface water were separated and concentrated by solid phase extraction (SPE) and determined by high-performance liquid chromatography coupled with tandem mass spectrometry technique (LC-MS/MS). The concentration of pharmaceuticals in the Warta River was subject to significant (or moderate) fluctuations during the study period. Concentrations depended on weather conditions and disease periods (seasonal, epidemic).
Hydrokinetic Energy and Transient Accelerations of Marine Currents in Colombian Nearshore Waters
Authors: Rueda-Bayona Juan Gabriel , Cabello Eras Juan José , Caicedo-Laurido Ana Lucía , Guzmán Andrés , García Vélez José Luis
Published: July 2023

The transient acceleration of ocean currents, or internal waves, is hard to detect, because it does not have climate variability or regular manifestation in the sea. This fluctuation affects not only short-term oceanographic processes but also the hydrokinetic generation of power and the structural health of ocean technologies. Identifying and understanding the mechanisms that generate internal waves require long-term data on the kinetic and viscous–turbulent parameters of the water column measured over long intervals. In this sense, this study analyzed current profiles in nearshore waters (8.9 m depths) measured over six months in the Colombian Caribbean Sea and found internal waves due to the manifestation of transient acceleration propagating in two of the three layers of the water column. The analyzed time series of currents and turbulent kinetic profiles evidenced that transient waves occurred during changes in the surface winds. The applied methodology in this research allowed, for the first time in the study area, the detection of transient accelerations (±0.25 m/s2) that modified the hydrokinetic energy of the water column over short-term periods (6–24 h).
Time-Lag Response of Landslide to Reservoir Water Level Fluctuations during the Storage Period: A Case Study of Baihetan Reservoir
Authors: Yang Zhengrong , Xi Wenfei , Yang Zhiquan , Shi Zhengtao , Huang Guangcai , Guo Junqi , Yang Dongqing
Published: July 2023

Fluctuations in reservoir water levels exert a strong triggering effect on landslides along reservoir banks, constituting a long-term concern in the safe operation of hydroelectric projects and in the prevention and management of geological disasters. While existing research has investigated the impact of periodic water level changes on the deformation of reservoir bank landslides, observation and detection of such deformation are challenging, with noticeable gaps in understanding how these deformations respond to water level changes during the water impoundment period. To address this, our study targets the Baihetan Reservoir, leveraging 567 ascending and descending LiCSAR data and LiCSBAS (the small-baseline subset within LiCSAR) technology to construct a time series of ground deformations in the study area from 2019 to 2023. The TLCC (Time Lag Cross Correlation) model was employed to examine the time-lag response pattern of reservoir bank landslide deformations to reservoir water level changes during the impoundment period. Our findings indicate a clear time-lag response in reservoir bank landslide deformations to water level changes during the impoundment process. The rise in water levels emerged as a primary factor influencing the instability of reservoir bank landslides. During the half-year impoundment period of the Baihetan Reservoir, a time lag of 5–7 days was observed between landslide deformations and increases in water levels, with landslides on the eastern and western banks exhibiting differing time-lag response patterns. Our study illuminates the time-lag effect between water level changes during reservoir impoundment and reservoir bank landslide deformation monitoring. By proposing a quantitative analysis methodology utilizing LiCSBAS technology and the TLCC model, our findings can inform decision-making in the field of disaster prevention and reduction in reservoir engineering.
Analysis of Dry-Wet Changes and the Driving Factors in Mainland China under Climate Change
Authors: Tang Jie , Xin Yan , Xie Yun , Wang Wenting
Published: July 2023

Evaluation of changes in dry-wet climate is crucial in the context of global climate change to ensure regional water resources, ecosystem stability, and socio-economic development. Long-term daily meteorological data, including temperature, precipitation, relative humidity, wind speed, sunshine duration, and air pressure data from 1680 stations across mainland China from 1971 to 2019, were collected to investigate the temporal and spatial variations in aridity index (AI), precipitation (P), reference evapotranspiration (ET0), and the underlying driving climatic factors. Results indicated that the Northwest, Northeast, and Huang-Huai regions were undergoing significant wetting processes, while the Southwest and Southeast China were undergoing significant drying processes. The changing AI was mainly decided by the changing trends of ET0. For most regions, ET0 has undergone significant increases. The average increasing rate over mainland China was 3.76 mm/10a. Stations with decreasing trends were mainly located in the Tibet Plateau, Huang-Huai, and northern Northeast China. Trends in ET0 were negatively affected by the increasing changes in relative humidity and positively affected by the decreasing changes in wind speed and sunshine duration and the increasing changes in air temperature. Wind speed and relative humidity were found to be the main dominant factors driving the changes in ET0, and their contribution varied with regions. Huang-Huai and northern Northeast China showed a significant downward trend in ET0, mainly driven by the decrease in wind speed, while the increase in relative humidity was the primary contributor to the significant upward trends in ET0 across all other regions in China.
Optimal Load Sharing between Lithium-Ion Battery and Supercapacitor for Electric Vehicle Applications
Authors: Rezk Hegazy , Ghoniem Rania M.
Published: July 2023

There has been a suggestion for the best energy management method for an electric vehicle with a hybrid power system. The objective is to supply the electric vehicle with high-quality electricity. The hybrid power system comprises a supercapacitor (SC) bank and a lithium-ion battery. The recommended energy management plan attempts to maintain the bus voltage while providing the load demand with high-quality power under various circumstances. The management controller is built on a metaheuristic optimization technique that enhances the flatness theory-based controller’s trajectory generation parameters. The SC units control the DC bus while the battery balances the power on the common line. This study demonstrates the expected contribution using particle swarm optimization and performance are assessed under various optimization parameters, including population size and maximum iterations. Their effects on controller performance are examined in the study. The outcomes demonstrate that the number of iterations significantly influences the algorithm’s ability to determine the best controller parameters. The results imply that combining metaheuristic optimization techniques with flatness theory can enhance power quality. The suggested management algorithm ensures power is shared efficiently, protecting power sources and providing good power quality.
Manajemen Konflik Hak Penerbitan Berita Google dan Australia
Authors: Saefulloh Haris , Madu Ludiro
Published: July 2023

Google dan Australia melakukan manajemen konflik hak penerbitan berita pada tahun 2021. Dalam konflik tersebut Australia ingin Google membayar perusahaan media pada setiap berita yang mereka terbitkan secara daring. Puncak konflik terjadi ketika Google tidak setuju dan sempat mengancam hengkang. Teori yang digunakan dalam penelitian ini adalah teori manajemen konflik. Teori tersebut menyebutkan ada lima jenis manajemen konflik yang dapat digunakan tergantung dari prioritas aktor konflik. Jenis penelitian ini merupakan penelitian kualitatif deskriptif. Pengumpulan data dilakukan menggunakan metode dokumen yang kemudian dianalisis menggunakan model Miles dan Huberman. Hasil dari penelitian ini adalah bahwa Google dan Australia telah melakukan kompromi setelah satu tahun melakukan negosiasi dalam konflik hak penerbitan berita. Kompromi ini tertuang dalam amandemen Undang-undang News Media Bargaining Code yang awalnya digunakan sebagai alat Pemerintah Australia dalam mencapai tujuannya. 

Kata kunci: Australia, Google, Penyelenggara Sistem Elektronik, Undang-undang Tawar Media
Dampak Kebijakan Internment Camp China Terhadap Etnis Muslim Uighur dan Keamanan Xinjiang
Authors: Surya Lalu Dhiya Ditria Fadiyat , Setowara Subhan
Published: July 2023

Xinjiang is an autonomous region which are prone to terrorism and separatism. The Chinese government issued an internment camp policy as a form of separatism and terrorism prevention and safety for Xinjiang. The purpose of this study was to ascertain the impact of the internment camp policy on Xinjiang security and ethnic Uyghurs. Securitization is used to analyze the emergence of this policy, and one of the factor is the constructed threat created by the Chinese government. Using qualitative and descriptive method, it is known that almost all incidents were motivated by ethnicity and religion which led to the establishment of internment camps in Xinjiang. The policy aims to maintain the security of Xinjiang and also ensure that Uyghurs are not influenced by Islamic values. Another reason is because of the speech act by China about the dangers of terrorism and separatism carried out by Uyghurs. Consequently, China succeed securitizing Xinjiang, resulting  Uyghurs detained in internment camps. The impact  of the internment camp policy is that Xinjiang security is established, with the consequence of tight surveillance in the Xinjiang region to the extent of violating the privacy rights of the Uyghurs.

Keywords—China, Security, Securitization, Uighurs, Xinjiang
Peran Organization for Security and Cooperation in Europe (OSCE) pada Konflik Transnistria
Authors: Paksi Arie Kusuma , Ramadhani Muhammad Labib , Putri Andini Hayu Agus
Published: July 2023

This paper attempts to explain what efforts have been made by the Organization for Security and Cooperation in Europe (OSCE) to deal with the conflicts that occurred in Transnistria. OSCE is an intergovernmental cooperation organization in the field of defense and security. Transnistria is a region in Moldova. The history of this conflict occurred at a time of weakening influence until the collapse of the power of the Soviet Union. Which after Moldova's independence there was a group that declared independence from Moldova and made the name of a new country with the name Pridnestrovian Moldavian Soviet Socialist Republic or Transnistria. One of the triggers for this conflict is linguistic and cultural differences, where most Moldovan people are close to Romania while Transnistria is close to Slavic. This conflict caused many casualties, as well as ethnic and national sentiments from various groups. For this reason, OSCE, as the organization's defense and security organization, helps this conflict by carrying out several functions such as the Information function, regulatory function, and operational function.

Keywords — OSCE, Conflict, Moldova, Transnistria
Upaya Peningkatan Keamanan Siber Indonesia oleh Badan Siber dan Sandi Negara (BSSN) Tahun 2017-2020
Authors: Haryanto Agus , Sutra Satya Muhammad
Published: July 2023

Abstrak

Penelitian ini menganalisis mengenai upaya peningkatan keamanan siber yang dilakukan oleh Badan Siber dan Sandi Negara (BSSN) sebagai institusi keamanan siber nasional Indonesia. Dalam menganalisis hal tersebut, penulis menggunakan Teori Sekuritisasi serta Konsep Keamanan Siber. Berdasarkan data yang diperoleh, BSSN dibentuk berdasarkan peraturan presiden dengan tugas untuk melaksanakan keamanan dalam bidang siber secara efektif dan efisien dengan memanfaatkan, mengembangkan, serta mengkonsolidasikan berbagai unsur yang berkaitan dengan keamanan siber.  Dalam meningkatkan keamanan siber di Indonesia mengacu pada lima aspek pada Global Cybersecurity Index yaitu aspek hukum, aspek teknis, aspek organisasi, aspek pengembangan kapasitas, dan aspek kerja sama. Global Cybersecurity Index digunakan untuk mengukur komitmen suatu negara terkait kapabilitas keamanan siber di negaranya. Dengan adanya upaya-upaya yang dilakukan BSSN terkait peningkatan keamanan siber diharapkan dapat mengurangi resiko dan ancaman dalam ruang siber di Indonesia.

 Kata kunci— Badan Siber dan Sandi Negara, Indeks Keamanan Siber Global, Indonesia, Keamanan Siber
Effect of Different Geometric Porosities on Aerodynamic Characteristics of Supersonic Parachutes
Authors: Jiang Lulu , Jia He , Xu Xin , Rong Wei , Wang Qi , Chen Gang , Fan Jianhui , Xue Xiaopeng
Published: July 2023

The supersonic parachute plays an important role in the descent and landing of Mars missions. Next-generation supersonic parachutes, such as disksail parachutes, are alternatives to disk-gap-band (DGB) parachutes. Disksail parachutes have larger porous gaps and smaller porous seams on the canopy surface than DGB parachutes. To date, the influence mechanism of porous seams or gaps and their locations on the performance of supersonic parachute systems in Martian atmospheric conditions remains unclear. In this study, different canopy models with seams and gaps based on NASA’s supersonic disksail parachutes were designed, and the aerodynamic characteristics of such geometric porosity models were studied numerically. For seam-only models, the drag coefficient of the parachute decreases when the position of the seam is close to the middle of the canopy. When the seam is close to the mouth of the canopy, the pressure difference between the inner and outer surface of the canopy becomes small, reducing the risk of tearing the canopy. For gap-only models, the drag coefficient of the middle gap model is higher, while the lateral force stability of the top gap model is better. The results show that the addition of a seam can improve the drag performance of the top gap model and improve the lateral stability of the canopy with the middle gap. This study provides some theoretical references for designing the porosity of parachutes under different requirements for Mars exploration missions in the future.
Models and Strategies for
J
2
-Perturbed Orbital Pursuit–Evasion Games
Authors: Han Hongyu , Dang Zhaohui
Published: July 2023

This paper discusses the modeling and solving of orbital pursuit–evasion games (OPEGs) under
J
2
perturbation. The optimal long-range maneuver method under
J
2
perturbation is designed, and it is proved that the effect of eccentricity can be ignored when transfer times and the Δ
V
budgets are fixed. It is discovered that when the inclination between the initial and target orbit is equal and is between 10° and 25°, the whole maneuver process can be simplified to a fixed-inclination transfer. Subsequently, a long-term OPEG model is provided under the assumption of fixed inclination, zero eccentricity, and impulsive thrust. Winning conditions of OPEGs under
J
2
perturbation are then carefully derived, with long-time OPEG (
J
2
dominated) and short-time OPEG (traditional) separated, and typical tactics of both sides formulated and verified. These studies are further extended to the “Arrival time matching game” for maintaining/avoiding resonant arrival time under
J
2
perturbation, and the advantages and disadvantages of both sides are analyzed. The models and strategies obtained in this paper can be potentially used in practical applications of OPEGs, especially for evaders that have low thrust–weight ratios and are weak in traditional short-term OPEGs.
Propuestas antipolíticas ante la crisis de la democracia
Authors: Gustavo Román Jacobo
Published: July 2023

El artículo explica por qué tanto la información sobre los asuntos públicos como el conocimiento para aprovecharla, con que cuenten los ciudadanos, son claves para el ejercicio de sus deberes y derechos políticos, y por qué la desinformación y la desigualdad son graves obstáculos para la efectividad de esa intervención ciudadana en la discusión y decisión de los asuntos comunes. Advierte que, frente a esa situación, han surgido cuatro propuestas de superación de la crisis de la democracia (la epistocrática, la tecnocrática, la sorteocrática y la de la ciberdemocracia populista) que son peligrosamente antipolíticas o antidemocráticas. Confronta esas propuestas haciendo una apuesta por la profundización de la democracia desde su principio ético fundamental: el reconocimiento universalista de la capacidad de agencia en cada ciudadano. Concluye señalando líneas de reforma y acción política para hacer más efectiva y real esa condición.
Estadísticas del sufragio Presidencia, Vicepresidencias y Diputaciones Elecciones Nacionales 6 de febrero, 2022
Authors: Costa Rica Tribunal Supremo de Elecciones
Published: July 2023

Presenta los datos estadísticos de las elecciones nacionales realizada en el mes de febrero de 2022 para los puestos de elección popular de presidencia, vicepresidencias y diputados
Uji Efektivitas Sediaan Gel Biji Muda Pepaya (Carica papaya L.) Terhadap Bakteri Methicillin-Resistant Staphylococcus aureus (MRSA)
Authors: Riski Radhia , Ismail Ismail , Mashar Harlyanti Muthma'innah , Ruslan Nurfahmi , Nisa Michrun , Ulfa Maria , Rahimah Sitti , Usman Dwi Anggara Putri
Published: July 2023

Biji muda pepaya (Carica papaya L.) diketahui memiliki khasiat sebagai antibakteri terhadap bakteri Methicillin-resistant Staphylococcus aureus (MRSA) dengan adanya kandungan terpenoid, karpain, dan flavonoid sehingga dapat diformulasi menjadi sediaan gel antibakteri. Penelitian ini bertujuan untuk mengetahui efektivitas sediaan gel ekstrak biji muda pepaya sebagai antibakteri terhadap bakteri MRSA. Ekstrak biji muda pepaya diperoleh dengan metode maserasi menggunakan pelarut etanol 70%. Uji aktivitas antibakteri ekstrak dibuat dalam 3 seri konsentrasi yaitu 7,5%, 10% dan 15%, kemudian diujikan pada bakteri MRSA. Ekstrak dengan konsentrasi 10% dengan diameter zona hambat 12,1 mm kemudian diformulasi dalam bentuk sediaan gel dengan menggunakan variasi konsentrasi gelling agent, FI (Carbopol 0.5%), FII (Carbopol 1%) dan FIII (Carbopol 2%). Berdasarkan hasil penelitian formula II sebagai formula stabil diuji efektivitasnya sebagai sediaan gel terhadap Methicillin-resistant Staphylococcus aureus dengan hasil diameter zona hambat sebesar 11,34 mm.
Formulation and Physical Stability of Temulawak (Curcuma xanthorhiza Roxb.) Antiaging Lotion with Natural Colorant from Strawberry Extract (Fragaria vesca L)
Authors: Alfian Muhammad , Maulana Mochamad Luqni , Mustainin Muhammad
Published: July 2023

Skin protection is needed to reduce the unwanted effects of free radicals, such as antiaging lotions. Temulawak (Curcuma xanthorhiza Roxb.) contains curcumin which has antioxidant activity with the potential to antiaging. Strawberries (Fragaria vesca L) contain anthocyanins known used as natural dyes. This study aims to determine the antioxidant activity of temulawak extract then formulated as a lotion with the addition of natural colorant from strawberries and tested for physical stability. Curcuma extraction was carried out by maceration using 70% ethanol solvent to obtain a thick extract, infundation method was used to extract a strawberry. Determination of the antioxidant activity of temulawak extract using the DPPH method is expressed by the IC50 value. The antioxidant activity of temulawak extract is included in the moderate category with an IC50 value   of  144.126   ppm.  Evaluation  of  physical  quality characteristics of temulawak lotion with natural colorant strawberry included organoleptic observations, spreadability, adhesion, pH test, viscosity, emulsion stability as well as stability to temperature and humidity. The results of the study after temperature and humidity treatment showed that the temulawak lotion was in the form of semi-solid, pink in color, the spreadability values were, respectively in centimeter 7.95 ; 7.35 ; 6.8 ; 7.05 ; 5.45 ; 5.85 ; 5.25 ; and 5.5 , the adhesive values are respectively in second 0.52 ; 0.56 ; 0.46 ; 0.51 ; 0.52 ; 0.50 ; 0.82 ; and 0.48, the pH value are 7; 6; 7; 7; 7; 7; 7; and 7, the viscosity values are in Pa.S  0.017; 0.031; 0.113; 0.055; 0.352; 0.263; 0.18; and 0.324. The conclusion of this study shows best formulation stability was formulas E, F, and H.
Analisis Efektivitas Biaya Kombinasi CCB-ACEI dan CCB-ARB pada Pasien Hipertensi dengan Penyerta DM Tipe II
Authors: Heroweti Junvidya , Rokhmawati Indah
Published: July 2023

Hipertensi dan DM merupakan kasus kronis yang dialami oleh usia degeneratif. Kombinasi terapi antihipertensi jangka panjang membutuhkan biaya tinggi. Analisis diperlukan untuk mengetahui efektifitas terapi dari segi biaya dalam memberikan outcome yang paling baik. Penelitian ini bertujuan untuk menganalisis efektifitas biaya terapi kombinasi obat antihipertensi pada pasien BPJS dengan penyerta DM tipe II pada pasien rawat jalan di RSI NU Demak. Penelitian observasional dilakukan dengan pendekatan analisis farmakoekonomi menggunakan cost effectiveness analysis dengan menghitung nilai ACER dan ICER. Pengambilan data retrospektif menggunakan rekam medis dan melihat biaya medis langsung. Data dikelompokkan berdasarkan pola terapi kemudian dilakukan analisis efektivitas biaya pada setiap kelompok terapi. Analisis efektivitas biaya dilakukan dengan cara menghitung biaya medis langsung, efektivitas terapi berdasarkan target minimal tekanan darah, serta menghitung nilai ACER dan ICER. Hasil penelitian menunjukkan antihipertensi yang paling cost-effective berdasarkan ACER adalah kombinasi golongan CCB-ACEI, kombinasi Amlodipin 10 mg–Lisinopril 10 mg dengan nilai sebesar Rp.6.388,70. Nilai ICER didapatkan antihipertensi yang paling cost-effective yaitu kombinasi golongan CCB-ARB dengan terapi Amlodipin 5 mg–Valsartan 160 mg yang menunjukkan nilai sebesar  Rp. – 58.401,38. Analisis sensitivitas menunjukkan bahwa penggunaan CCB-ARB lebih sensitif terhadap kenaikan 25% biaya dibandingkan dengan kombinasi CCB-ACEI.
Pengaruh Perbandingan Obat-Polimer terhadap Karakteristik Fisik Mikrokapsul Simvastatin
Authors: Kusumasari Findi Citra
Published: July 2023

Simvastatin adalah salah satu jenis obat untuk mengatasi hiperlipidemia yang memiliki efek samping yakni miopati dan rhabdomiolisis jika dikonsumsi dengan dosis tinggi. Sehingga dibutuhkan sistem pelepasan obat terkontrol untuk meminimalisir efek samping yang dihasilkan melalui pembuatan mikrokapsul dengan metode penguapan pelarut. Pembuatan mikrokapsul menggunakan polimer yang memiliki karakteristik biodegradable dan biocompatible yakni poli(L-asam laktat) dan polikaprolakton. Perlakuan yang diberikan yakni dengan memvariasikan perbandingan obat dengan jumlah polimer yang digunakan untuk memperoleh mikrokapsul terbaik dari aspek efisiensi enkapsulasi dan ukuran partikel. Berdasarkan penelitian yang dilakukan, mikrokapsul dengan perbandingan obat dan polimer 1:12,5 memiliki nilia efisiensi enkapsulasi sebesar 84,73±1,5% dengan ukuran sebesar 0,45±0,01µm. Nilai efisiensi enkapsulasi tidak bisa maksimal disebabkan pada saat proses pemadatan mikrokapsul, diklorometana menghasilkan lubang pada permukaan mikrokapsul yang diamati dengan menggunakan Scanning Electron Microscope (SEM) sehingga difusi obat ke fase eksternal lebih mudah.
Skrining Fitokimia dan Penentuan Kadar Flavonoid Ekstrak Etanol Limbah Kulit Pisang (Musa acuminata Colla)
Authors: Larasati Dwi , Putri Filu Marwati Santoso
Published: July 2023

Kulit pisang umumnya dianggap sebagai limbah sampah yang tidak digunakan. Senyawa aktif yang terkandung di dalam kulit pisang diantaranya senyawa flavonoid dan fenol yang bersifat antioksidan. Flavonoid merupakan bagian dari senyawa turunan polyphenolic yang terdapat pada tumbuhan. Tanin merupakan senyawa polifenol yang dimiliki kulit pisang. Tujuan penelitian ini dilakukan yaitu untuk menentukan kadar flavonoid ektrak etanol kulit pisang. Ekstrak etanol kulit pisang dihasilkan melalui metode maserasi dengan pelarut etanol 70%. Hasil identifikasi kualitatif dari ekstrak etanol kulit pisang mengandung senyawa diantaranya flavonoid, steroid dan tanin galat. Penetapan kandungan flavonoid dilakukan panjang gelombang maksimum 435 nm berdasarkan metode AlCl3. Kandungan flavonoid yang  dihasilkan yaitu 0,175%.
Formulasi dan Uji Stabilitas Sediaan Hair Emulsion Minyak Biji Chia (Salvia hispanica) dengan Kombinasi Tween 80 dan Span 80 Sebagai Emulgator
Authors: Rahmayanti Mayu , Nastiti Ginanjar Putri , Fitri Mutia Azkia
Published: July 2023

Hair emulsion saat ini sudah banyak dikembangkan untuk mengatasi kerontokan dan kebotakan pada rambut, baik dari produk yang terbuat dari bahan sintetis maupun dari bahan alam. Namun, penggunaan bahan sintetis dapat menyebabkan iritasi pada kulit, gatal-gatal, alergi, dan beberapa efek samping lainnya. Salah satu solusi untuk menghindarinya adalah dengan menggunakan bahan alami. Minyak biji chia memiliki beragam potensi kesehatan, secara umum di masyarakat penggunaannya sebagai sumber pangan, tetapi minyak biji chia juga dapat dimanfaatkan untuk perangsang pertumbuhan rambut karena mengandung asam linoleat. Penelitian ini bertujuan untuk mengetahui sifat fisik dan stabilitas fisik sediaan hair emulsion dari minyak biji chia sebagai penumbuh rambut. Hair emulsion dibuat menggunakan metode basah dengan kombinasi emulgator span 80 dan tween 80. Evaluasi fisik sediaan meliputi uji organoleptis, pH, tipe emulsi, dan homogenitas. Uji stabilitas sediaan dilakukan dengan penyimpanan pada suhu ruang selama 21 hari dan cycling test sebanyak 6 siklus. Data yang diperoleh dianalisis dengan pendekatan teoritis dan analisis statistik. Formulasi sediaan dengan variasi konsentrasiminyak biji chia menghasilkan sediaan emulsi tipe m/a yang homogen, berwarna putih susu, beraroma khas minyak biji chia dan memiliki pH pada rentang 4-7. Berdasarkan analisis statistik, formula I dan II tidak menunjukkan adanya signifikansi setelah dilakukan uji stabilitas pada nilai pH, sedangkan penurunan nilai pH pada formula III memiliki nilai signifikansi p (0,00) < 0,05. Berdasarkan data yang diperoleh dapat disimpulkan bahwa FI dan FII memiliki sifat fisik dan stabilitas yang baik, sedangkan FIII memiliki nilai pH yang tidak memenuhi syarat pH yang baik dan tidak stabil selama penyimpanan
Penyuluhan Pengobatan Tradisional ISPA Pada Balita di Gampong Bireuen Meunasah Reuleut Provinsi Aceh
Authors: Chaizuran Meutia , Hijriana Isni
Published: July 2023

Traditional medicine for acute respiratory tract syndrome  is medicine given to acute respiratory tract syndrome  clients using spices found in home namely ginger and turmeric.counseling technique can be used to give information to community regarding traditional medicine.this community service activity conducted counseling in Bireuen Meunasah Reuleut Village, Aceh Province.this counseling aims to provide knowledge and ability to using spices as medicine.The counseling using material delivery and demonstration with power point presentation.The result showed increase for knowledge of acute respiratory tract syndrome disease and medicine using the traditional.
PENGENALAN LANGUAGE TESTING BAGI SISWA DAN KERJASAMA (PKS) DI SMA NEGERI 8 PERBATASAN KABUPATEN MALINAU, INDONESIA
Authors: Arifin Arifin , Kusmaryani Woro , Winarno Winarno , Fitriawati Fitriawati , Ramli Ramli , Setyawan Farid Helmi
Published: July 2023

Pengabdian Program Studi Pendidikan Bahasa Inggris, Universitas Borneo Tarakan difokuskan pada dua aspek penting yaitu, pengenalan language testing (TEOFL) kepada calon mahasiswa mahasiswa Universitas Borneo Tarakan yang saat ini berada di kelas 3 SMA, dan melaksanakan Perjanjian Kerjasama (PKS) kepada Sekolah Mitra SMA Negeri 8 Kabupaten Malinau. Metode yang dipergunakan dalam pengabdian kepada Masyarakat adalah Metode SPEQAR (Speech Question Answer dan Reflective). Hasil pengabdian yang dilaksanakan adalah proses pengenalan language testing (TEOFL) masih membutuhkan waktu yang cukup dalam pendampingan siswa kelas 3 karena mereka masih belum mengenal sepenuhnya jenis tes yang sudah berstandar internasional. Selain itu, pendampingan pada guru mata pelajaran perlu dilakukan sebagai wujud dari realisasi kerjasama. Pelaksanaan Perjanjian Kerjasama (PKS) antar Program Studi dan SMA Negeri 8 Malinau difokuskan pada tiga aspek penting, yaitu melaksanakan Pendampingan Penelitian Tindakan Kelas, Join Paper/ Join Publication antara Dosen (pihak pertama) dan guru (pihak kedua) sebagai bentuk peningkatan kapasistas sumber daya manusia kedua belah pihak, dan mendukung kegiatan penelitian, pengajaran, dan pengabdian masyarakat di Sekolah Menengah Atas (SMA) Negeri 8  Malinau sebagai Sekolah Mitra.
STRATEGI PENINGKATAN ATAU UMKM NAIK KELAS MELALUI TATA KELOLA KEUANGAN YANG HANDAL PADA UMKM
Authors: Maula Kholida Atiyatul , Pardistya Irvan Yoga , Fardhyanti Ardhya Fauzah , Nurcahyani Anita , Prawira Ugy Alamsyah
Published: July 2023

Laporan keuangan dibuat berdasarkan pendapatannya saja seperti perhitungan modal, beban- beban serta omset penjualan per hari. beberapa pelaku UMKM di Desa Sindangkarya belum menganggap penting laporan keuangan, sedangkan salah satu indikator utama yang menunjukan keberhasilan UMKM dalam mempertanggung jawabkan pengelolaan keuangan adalah terwujudnya laporan keuangan yang berkualitas. Kegiatan pengabdian masyarakat melalui program pelatihan membuat Laporan Keuangan pada UMKM serta strategi Digital Marketing demi meningkatkan profitabilitas di Desa Sindangkarya ini diharapkan dapat membantu para UMKM dalam kegiatan usahanya agar terus berjalan dan bisa meningkatkan keuntungan dari hasil jualan produk mereka, khususnya para UMKM di Desa Sindangkarya yang menjadi mitra kita pada pengabdian ini. Secara terperinci kegiatan tersebut dapat disimpulkan dengan pemahaman dalam membuat laporan keuangan yang sesuai dengan SAK ETAP, pemahaman dan pemanfaatan teknologi dalam memasarkan produk dalam bentuk digital seperti instagram, gofood, shopee, juga pemahaman dalam membuat produk baru, pengemasan produk dan pemasaran produk.
Pelatihan Peningkatan Pengetahuan Pengurus KUBE tentang Modal yang Dimiliki
Authors: Ibnu Muhammad , Nikmatullah Dewangga , Wijayanti Yayuk
Published: July 2023

Kelompok Usaha Bersama (KUBE) merupakan program pemberdayaan dalam rangka penanggulangan kemiskinan secara kelompok. Berdasarkan berbagai sumber referensi dan observasi langsung di lapangan, ditemukan bahwa masalah umum yang menjadi hambatan berkembangnya KUBE adalah lemahnya SDM pengelola, keterbatasan modal, dan kesulitan pemasaran. Banyak KUBE tampaknya berpikir terlalu sempit mengenai jenis usaha yang bisa dilakukannya. Namun, secara umum dapat ditarik benang merah bahwa masalahnya adalah banyak pengelola KUBE yang belum mengerti tentang potensi basic material dan social asset (baik yang berwujud maupun tidak berwujud) yang dimilikinya. Tujuan yang diharapkan dari pengabdian masyarakat ini yaitu peningkatan pengetahuan dan kesadaran tentang basic material dan social asset yang dimiliki oleh masing-masing KUBE. Berdasarkan hasil post-test tersebut ditemukan bahwa para peserta pengabdian pada umumnya bisa memahami pengertian KUBE dan tujuan didirikannya badan usaha tersebut dengan lebih baik. Para peserta juga mendapatkan nilai rata-rata yang lebih tinggi terkait pengetahuan dan/atau pemahaman tentang basic material dan social asset yang dimiliki desa dan/atau badan usahanya. Berdasarkan kesulitan-kesulitan yang dikemukakan pengelola KUBE, tim pengabdian  menyarankan beberapa strategi untuk membangun bisnis KUBE agar tidak gagal atau memperkecil risiko gagal.
Penerapan Tri-N dalam Pengajaran Articles bagi Siswa SMA di Lamongan secara Daring
Authors: Hikmah Isti'anatul , Hidayah Anis
Published: July 2023

Tema dari kegiatan abdimas ini adalah pengajaran bahasa Inggris yang dilakukan secara daring di Lamongan. Tema pengajaran bahasa Inggris dispesifikkan pada materi articles yang terdiri dari a, an, dan the. Materi tersebut diajarkan pada siswa Sekolah Menengah Atas (SMA) di Lamongan dengan mengimplementasikan Tri-N (niteni, niroke, dan nambahi) sehingga tujuan dari kegiatan abdimas ini adalah mengimplementasikan Tri-N dalam pengajaran articles bagi siswa SMA di Lamongan. Pelaksanaan pengajaran dalam kegiatan ini menggunakan metode Tri-N. Para siswa niteni atau mengidentifikasi penjelasan articles, niroke atau menirukan penjelasan dan kegiatan-kegiatan yang disajikan secara daring, dan nambahi atau menambahi penjelasan maupun kegiatan-kegiatan yang dilakukan secara daring terkait dengan articles. Semua proses pengajaran dalam kegiatan ini dilakukan dengan menggunakan media Zoom. Adapun hasil dari abdimas ini adalah: (1) para siswa mampu memahami articles; dan (2) mampu menggunakannya secara tulis dan lisan dalam bentuk frasa seperti an apple, a house, dan the sun.  

Kata kunci: articles; pembelajaran daring; tri-n
Prevention of Hypertension and Diabetes Mellitus Based on Health Education in the Community of Sungai Rangas Village, West Martapura
Authors: Aridamayanti Bernadetta Germia , Septiany Maulidya , Agianto Agianto , Diani Noor
Published: July 2023

Penyakit hipertensi dan Diabetes Mellitus merupakan penyakit kronis yang memiliki konotasi budaya karena perilaku hidup yang tidak sehat. Hipertensi dan Diabetes Mellitus akan menyebabkan peningkatan tekanan darah abnormal yang dapat menjadi penyebab utama timbulnya penyakit kardiovaskuler serta gangguan metabolik dalam tubuh. Berbagai macam upaya dilakukan untuk menekan dan mencegah kejadian Hipertensi dan Diabetes Mellitus. Salah satu upaya yang dilakukan yakni melakukan pendidikan kesehatan kepada masyarakat melalui kegiatan pengabdian kepada  masyarakat.  Pengabdian  masyarakat  ini  bertujuan  untuk  meningkatkan pengetahuan tentang pencegahan hipertensi dan manajemen diabetes mellitus serta meningkatkan status kesehatan masyarakat. Pengabdian masyarakat ini juga bagian dari kerja sama antara institusi perguruan tinggi dengan lintas sektor di Desa Sungai Rangas, Kecamatan Martapura Barat, Kabupaten Banjar. Kegiatan pengabdian masyarakat ini diikuti  sebanyak 95 orang yang terdiri dari 58 orang laki-laki dan 37 orang perempuan, dengan rentang usia antara 15-87 tahun. Masyarakat merasa antusias mengikuti kegiatan edukasi  kesehatan tersebut. Kegiatan ini diharapkan dapat meningkatkan informasi dan  pengetahuan masyarakat serta mampu berkontribusi secara nyata dalam mendukung upaya pemerintah menurunkan kejadian hipertensi dan diabetes mellitus.

 

Kata kunci: hipertensi; diabetes mellitus; pendidikan kesehatan.
Analytic Hierarchy Process Based Selection of Leaders of Start-up Enterprises
Authors: Yan Yuyang , Mercado Cecilia A.
Published: July 2023

The strength of leadership in the context of start-ups is closely related to the innovation and development of enterprises. The stronger the leadership of enterprises, the better the innovation and development of enterprises. Therefore, it is of great significance to study the leadership of enterprises. We can cultivate and improve enterprise leadership to meet enterprises' innovation and development needs in different situations. This paper uses four factors to evaluate enterprise leadership: strategic, communication, personal, and incentive. Assuming the relationship of various influencing factors, it establishes an analytic hierarchy process (AHP) model to select the best leaders among three kinds of enterprise leaders. This offers guidance that contributes to the theory and application of the AHP.
Unraveling the Link between Financial Performance and Mudaraba Deposit Returns: The Case of Full-fledged Islamic Bank
Authors: Kristianingsih Kristianingsih , Ramdani Mochamad Rizki , Karnawati Hennidah , Purwihartuti Koernia , Hazma Hazma , Setiawardani Maya
Published: July 2023

The goal of this study was to examine the impact of various factors on the profit-sharing level of Mudaraba deposits held by fully-fledged Islamic banks, including profitability level, profitability level, financing risk level, liquidity level, operational efficiency level, and capital adequacy level. A quantitative descriptive method with panel data regression analysis techniques was used in this investigation. The approaches used for data collecting included documentation and literature study. 168 observational data were collected across 7 Full-Fledged Islamic Banks over the course of six years, from 2017 to 2022. The findings demonstrated that the profit-sharing rate of Mudaraba deposits was significantly influenced by the levels of profitability, financing risk, liquidity, operational efficiency, and capital sufficiency at the same time. The amount of profitability, the level of financing risk, and the level of operational efficiency all somewhat influence the profit-sharing rate for Mudaraba deposits in a positive and significant way. The profit-sharing rate of Mudaraba deposits is unaffected by both liquidity and capital adequacy levels.
Navigating Uncertain Times: Comparative Analysis of Islamic Banking Financial Performance in Indonesia Before and During the Covid-19 Pandemic
Authors: Afandi Azwar , Hermawan Dadang
Published: July 2023

This study analyzes the comparison of the financial performance of Islamic banks in Indonesia before and during the Covid-19 pandemic. The population used in this study consists of Islamic Commercial Banks in Indonesia. The research method employed is quantitative research with a comparative approach using IBM SPSS Statistics 25 software. The data used are secondary data in the form of financial reports published by each company's website from 2018 to 2021. The results of this study indicate significant differences in CAR and ROA ratios between before and during the Covid-19 pandemic. However, there are no significant differences in NPF, OER, and FDR ratios between before and during the Covid-19 pandemic. Furthermore, there are significant simultaneous differences in financial performance before and during the Covid-19 pandemic. This comparative analysis sheds light on the dynamic nature of Islamic banking financial performance during the Covid-19 pandemic. The findings provide valuable insights for policymakers, bank regulators, and industry stakeholders in understanding the sector's resilience and the need for adaptive strategies during times of crisis.
PENGENALAN KONSEP ETNOMATEMATIKA MELALUI KEGIATAN EKSPLORASI BUDAYA LOKAL BANYUWANGI
Authors: Masruroh Farhatin , Ulfah Maulidya , Khulusinniyah  , Soliha Umdatus
Published: July 2023

The introduction of ethnomathematics concepts through this exploration activity is very important to be applied to Early Childhood Education institutions. Because this activity aims to improve the ability to learn mathematics and culture in children, children must be introduced to ethnomathematics learning from an early age. This study uses Action Research with 2 cycles through planning, observation, implementation, and action procedures. The formulation of the problems in this study are: 1) How is the introduction of ethnomathematics concepts through Banyuwangi local cultural exploration activities 2) What are the results of the introduction of ethnomathematics concepts through Banyuwangi local cultural exploration activities, While the results of the study: 1) The process carried out is that children carry out mathematical exploration activities with objects typical of Banyuwangi culture with varied activities. 2) Research results In the pre-cycle the percentage of children was 35% and after the action was carried out in cycle I only 11 children out of a total of 17 children were declared able to achieve the minimum completeness criteria, with a percentage of 65%. Whereas in cycle II there were 14 children who had succeeded in achieving the minimum completeness criteria with a percentage of 82%. Based on the results of cycle II, it was not continued in the next cycle because it had reached the set classical completeness target, namely 80%.