bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening oat germplasm for better adaptation to cold stress in the Southern Great Plains of the United States
Authors: Ayalew Habtamu , Anderson Joshua D. , Kumssa Tadele T. , Maulana Frank , Ma Xue‐Feng
Published: November 2018

Oat (Avena sativa L.) is one of the most important forage crops in the Southern Great Plains of the United States. However, it is more sensitive to cold stress than other small grains. In this study, diverse oat germplasm was evaluated for winter survival across multiple years and locations in the region. Field screening started with an observation trial of 1,861 diverse genotypes in the 2012–2013 season and was followed by four seasons of replicated trials from 2013 to 2017. Selection of good winter survivors was started in 2014–2015 season. All trials were laid out in randomized complete blocks with replications of two in 2013–2014 and 2014–2015, four in 2015–2016, and three in 2016–2017. Winter survival was scored in a 1‐to‐9 scale. Data were analysed for each year and location separately. Additive main effects and multiplicative interaction (AMMI) analysis were carried out on combined data of 35 genotypes that were commonly grown in each year and location. Highly significant (p < 0.001) variations were observed among genotypes, environments and genotype‐by‐environment interaction (GEI). The first three interaction principal components (IPCs) were highly significant (p < 0.001), explaining 96% of GEI. Broad sense heritability ranged from 46% to 93%, while heritability for all environments combined was relatively low (24.6%). At the end of the two cycles (2014/2015‐to‐2016/2017) of selection, mean winter survival was improved by more than 38% per cycle compared with the base population mean. Genotypes CIav 4390, CIav 6909 and CIav 7618 showed significantly higher winter survival than the standard checks Okay and Dallas. Genotypes CIav 4390 showed 20% and 35% improvement over the standard checks Okay and Dallas, respectively. Winter survival improvement in oat will remain a difficult task because of high GEI and low heritability. The identified superior genotypes will be used as crossing parents to transfer cold tolerance genes to other elite lines.
γ‐secretase inhibitor DAPT mitigates cisplatin‐induced acute kidney injury by suppressing Notch1 signaling
Authors: Soni Hitesh , Matthews Anberitha T. , Pallikkuth Sandeep , Gangaraju Rajashekhar , Adebiyi Adebowale
Published: November 2018

Organ toxicity, including kidney injury, limits the use of cisplatin for the treatment of multiple human cancers. Hence, interventions to alleviate cisplatin‐induced nephropathy are of benefit to cancer patients. Recent studies have demonstrated that pharmacological inhibition of the Notch signaling pathway enhances cisplatin efficacy against several cancer cells. However, whether augmentation of the anti‐cancer effect of cisplatin by Notch inhibition comes at the cost of increased kidney injury is unclear. We show here that treatment of mice with cisplatin resulted in a significant increase in Notch ligand Delta‐like 1 (Dll1) and Notch1 intracellular domain (N1ICD) protein expression levels in the kidneys. N‐[N‐(3,5‐difluorophenacetyl)‐L‐alanyl]‐S‐phenylglycine t‐butyl ester (DAPT), a γ‐secretase inhibitor reversed cisplatin‐induced increase in renal N1ICD expression and plasma or urinary levels of predictive biomarkers of acute kidney injury (AKI). DAPT also mitigated cisplatin‐induced tubular injury and reduction in glomerular filtration rate. Real‐time multiphoton microscopy revealed marked necrosis and peritubular vascular dysfunction in the kidneys of cisplatin‐treated mice which were abrogated by DAPT. Cisplatin‐induced Dll1/Notch1 signaling was recapitulated in a human proximal tubule epithelial cell line (HK‐2). siRNA‐mediated Dll1 knockdown and DAPT attenuated cisplatin‐induced Notch1 cleavage and cytotoxicity in HK‐2 cells. These data suggest that Dll1‐mediated Notch1 signaling contributes to cisplatin‐induced AKI. Hence, the Notch signaling pathway could be a potential therapeutic target to alleviate renal complications associated with cisplatin chemotherapy.
Decreasing sunbed use in the German population between 2001 and 2015: survey in 155 679 working persons
Authors: Augustin M. , Schäfer I. , Krensel M. , Reusch M. , Mohr P. , Greinert R. , John S.M. , Zander N.
Published: November 2018

Background

UV radiation is a proven cause of skin cancer. Use of sunbeds has been shown to provide an attributable risk.

Objective

To evaluate the proportion of regular sunbed use in Germany based on large‐scale population‐based surveys over 15 years.

Methods

Skin cancer screenings by dermatologists were conducted between 2001 and 2015 in more than 500 German companies, including a clinical examination and interviews on the risk behaviour related to sunburns and sunbeds.

Results

Among 155 679 persons included regular sunbed use significantly declined from 11.0% in 2001 to 1.6% in 2015 (P < 0.001). There were significantly higher rates of sunbed use in women (12.5%/2.0%) vs. men (7.3%/1.3%; P < 0.001), in younger persons and in participants with darker skin (type II and III) vs. fair skin (type I). Individuals with sunburns in childhood were significantly more often sunbed users (5.1% vs. 4.6%; P = 0.002). A remarkable decline of sunbed use was observed after 2009 (7.0% in 2001–2008 and 2.2% in 2009–2015). This reduction occurred in the time of a legal ban of sunbed use for minors but also with the start of the national skin cancer screening programme.

Conclusion

Use of sunbeds in the German adult population has dropped by more than 85% in the past decade. Primary prevention, including the large public awareness following the legal ban of sunbed use for young people and the effects of the statutory skin cancer screening programme may have contributed to this.
Providing patients visiting emergency departments with useful information using public real time data: A case study based on Italian data
Authors: Lusa Lara , Bukovšek David
Published: November 2018

Rationale, aims, and objectives

Many hospitals provide some type of real time publicly available information about the crowding of the emergency departments (EDs). For example, at the time of writing, the number of patients waiting and in treatment is publicly available for EDs that cover more than half of the Italian population. However, usually, these data do not provide the key information that low‐priority patients are seeking, which is the time they might expect to wait before being seen by a doctor.

Methods

In this paper, we reanalyze the prospectively collected public data from the two major EDs of the Friuli Venezia Giulia Italian region, which maintains a web page that provides a real time estimate of the average waiting time of current ED patients. The paper discusses the usefulness of the estimate from the patients' prospective.

Results

We point out a flow of the methodology used on web page of the Friuli Venezia Giulia region, and further show that the waiting time of current patients reflects poorly the expected time to treatment of new patients.

Discussion

The results suggest that available data should be used to develop and validate ED‐specific waiting time prediction models of low‐priority patients. The same data could also be used to estimate quantities that might be of interest for EDs resource management.
Falls resulting in health care among older people with intellectual disability in comparison with the general population
Authors: Axmon A. , Ahlström G. , Sandberg M.
Published: November 2018

Background

Falls are common among older people with intellectual disability (ID) and are also a major contributor to injuries in this population. Yet, fall characteristics have only been sparsely studied, and the results are inconsistent. The aim of the present study was to investigate type of falls, places where they occurred and activities that caused them, as well as health outcomes and health utilisation patterns after falls, among older people with ID in comparison with their age peers in the general population.

Methods

We established an administrative cohort of people with ID aged 55 years, or more, and alive at the end of 2012 (ID cohort; n = 7936). A cohort from the general population, one‐to‐one matched by sex and year of birth, was used as referents. Data regarding fall‐induced health care episodes in inpatient and outpatient specialist care were collected from the National Patient Register for the period 2002–2012.

Results

With the exception of falls from one level to another (i.e. fall on and from stairs and steps, ladder and scaffolding; fall from, out of or through building or structure; fall from tree or cliff and diving or jumping into water; or other fall from one level to another), people in the ID cohort were more likely to fall and fall more often than those in the general population cohort. Falls during a vital activity (e.g. attending to personal hygiene or eating) were twice as common among people with ID compared with the general population. When falling, people with ID were more likely to injure their head and legs but less likely to sustain injuries to the thorax and elbow/forearm. They were more likely to have superficial injuries, open wounds and fractures but less likely to have dislocations, sprain and strains. Fall‐related health care visits among people with ID were more likely to be in inpatient care and be unplanned. People with ID were also more likely than those in the general population to have a readmission within 30 days.

Conclusions

People with ID are more likely to require specialist care after a fall and also more likely to obtain injuries to the head, compared with the general population. This is important to consider when taking preventive measures to reduce falls and fall‐related injuries.
Eviscerating Historic Treaties: Judicial Reasoning, Settler Colonialism, and ‘Legal’ Exercises of Exclusion
Authors: McCrossan Michael
Published: November 2018

This article examines the reasoning of Canadian Supreme Court justices in the area of Aboriginal treaty rights, paying particular attention to the Grassy Narrows (2014) decision. By not only engaging with the internal logics contained within treaty rights decisions, but also by further contextualizing the decisions and comparing them to the transcripts of their respective hearings, it provides an additional perspective on the socio‐cultural relations of power inscribed within the legal field. Ultimately, the article demonstrates that members of the Supreme Court have displayed a consistent orientation towards logics predicated upon the absorption and elimination of Indigenous legal perspectives. In fact, what a reading of the hearing transcripts together with the Grassy Narrows decision reveals is a judicial privileging of established property interests and extractive impulses underpinning the settler‐colonial development of the Canadian state.
The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses
Authors: Sun Jiajie , Xiong Jiali , Yao Liyuan , Chen Ting , Luo Junyi , Xi Qianyun , Zhang Yongliang
Published: November 2018

Ginseng polysaccharides (GPS) have been well known as an immune modulator. This study was conducted to investigate the effects of dietary supplemental GPS on the immune responses involved in sow’s milk‐derived exosomal shuttle RNAs (esRNAs) using RNA‐Seq and miRNA‐Seq. Of the 213 identified miRNA types, a total of 26 conserved miRNAs were differently expressed in response to GPS supplementation, including 10 up‐regulated and 16 down‐regulated miRNAs in GPS feeding group. In addition, exosomal transcriptome analysis identified 14,696 protein‐coding genes in sow’s milk exosomes, and 283 genes with 204 and 79 candidates showing up and down‐regulation were significantly responded to GPS supplementation. Integrated analysis of each differently expressed miRNA with significantly expressed genes further revealed the presence of 51 highly conserved miRNA–gene interactions that were annotated to be related to immunoregulatory functions. This work provided an important advance in the functional identification of dietary GPS supplementation and more fundamental information about how GPS promoted the immune response and healthy growth of the infant from mothers at molecular levels.
Ability of the Fitbit Alta HR to quantify and classify sleep in patients with suspected central disorders of hypersomnolence: A comparison against polysomnography
Authors: Cook Jesse D. , Eftekari Sahand C. , Dallmann Erika , Sippy Megan , Plante David T.
Published: November 2018

Measuring sleep duration and early onset rapid eye movement sleep (REMS) is critical in the assessment of suspected central disorders of hypersomnolence (CDH). Current multi‐sensor activity trackers that integrate accelerometry and heart rate are purported to accurately quantify sleep time and REMS; however, their utility in suspected CDH has not been established. This investigation aimed to determine the ability of a current, multi‐sensor tracker, Fitbit Alta HR (FBA‐HR), to quantify and classify sleep in patients with suspected CDH relative to polysomnography (PSG). Forty‐nine patients (46 female; mean age, 30.3 ± 9.84 years) underwent ad libitum PSG with concurrent use of the FBA‐HR. FBA‐HR sleep variable quantification was assessed using Bland‐Altman analysis. FBA‐HR all sleep (AS), light sleep (LS; PSG N1 + N2), deep sleep (DS; PSG N3) and REMS classification was evaluated using epoch‐by‐epoch comparisons. FBA‐HR‐detected sleep‐onset rapid eye movement periods (SOREMPs) were compared against PSG SOMREMPs. FBA‐HR displayed significant overestimation of total sleep time (11.6 min), sleep efficiency (1.98%) and duration of deep sleep (18.2 min). FBA‐HR sensitivity and specificity were as follows: AS, 0.96, 0.58; LS, 0.73, 0.72;DS, 0.67, 0.92; REMS, 0.74, 0.93. The device failed to detect any nocturnal SOREMPs. Device performance did not differ appreciably among diagnostic subgroups. These results suggest FBA‐HR cannot replace EEG‐based measurements of sleep and wake in the diagnostic assessment of suspected CDH, and that improvements in device performance are required prior to adoption in clinical or research settings.
Pharmacokinetic/pharmacodynamic integration of cefquinome against Pasteurella Multocida in a piglet tissue cage model
Authors: Zhang Longfei , Wu Xun , Huang Zilong , Kang Zheng , Chen Yuqin , Shen Xiangguang , Cai Qinren , Ding Huanzhong
Published: November 2018

To explore the in vivo antimicrobial activity of cefquinome against Pasteurella multocida in piglets, a piglet tissue cage infection model was used in this study. After the population of P. multocida reached 107 CFU/mL in a tissue cage, piglets received an intramuscular administration of cefquinome at 0.2, 0.4, 0.8, 1, 2, and 4 mg/kg once daily for 3 days. To assess the tissue cage pharmacokinetics (PKTCF) of cefquinome, tissue cage fluid was collected for cefquinome analysis at 1, 3, 6, 9, 12, and 24 hr after each of the 3 daily drug administrations. Bacteria were counted every 24 hr after drug administration and at 48 and 72 hr after the last administration. Evaluation of the relationship between pharmacokinetic/pharmacodynamic (PK/PD) parameters and the antibacterial effect showed that the surrogate of %T > minimum inhibitory concentration (MIC) (R2 = 0.981) was the best PK/PD index that correlated with effectiveness of cefquinome against P. multocida. The respective values of %T > MIC required for continuous 1/3‐log, 1/2‐log, and 1‐log reductions were 14.23, 34.45, and 73.44%, respectively, during each 24‐hr treatment period. In conclusion, cefquinome exhibited a potent antibacterial effect against P. multocida. When %T > MIC reached 73.44%, cefquinome exhibited a bactericidal effect against P. multocida after three successive daily administrations.
Methylglyoxal as a prognostic factor in patients with chronic kidney disease
Authors: Tezuka Yuta , Nakaya Izaya , Nakayama Keisuke , Nakayama Masaaki , Yahata Mayumi , Soma Jun
Published: November 2018

Aim

Advanced glycation end products and their precursors cause vascular damage through oxidative stress. We investigated the hypothesis that methylglyoxal (MG), 3‐deoxyglucosone (3‐DG) and pentosidine influence outcomes of chronic kidney disease (CKD) patients.

Methods

We conducted a 3 years prospective observational study involving 150 outpatients at CKD stages 3–5. At enrolment, MG, 3‐DG and pentosidine plasma concentrations were measured; patients were divided into tertiles according to the concentration of each substance. The primary endpoint was death, a cardiovascular event or end‐stage renal disease. Survival analysis was performed using the Cox regression model.

Results

The patients’ mean age was 62 ± 12 years, 97 were men, and 20 had diabetic nephropathy. The mean estimated glomerular filtration rate was 25.0 ± 12.1 mL/min per 1.73 m2, which negatively correlated with MG but not with 3‐DG and pentosidine. Forty‐eight patients reached the primary endpoint. Compared with the lowest MG tertile, the hazard ratio for the primary endpoint was 7.57 (95% confidence interval (CI): 1.71–33.54) in the middle tertile and 27.00 (CI: 6.46–112.82) in the highest tertile. When adjusted for characteristics at baseline, the corresponding hazard ratio decreased to 2.09 (CI: 0.37–11.96) and 6.13 (CI: 0.97–38.82), but MG tertile remained an independent risk factor for the primary endpoint. However, 3‐DG and pentosidine were not related to the primary outcome.

Conclusion

Methylglyoxal has a close clinical association with CKD. Higher MG concentrations may contribute renal function deterioration in CKD. In CKD patients, MG concentration might be useful when determining the prognosis.
Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis
Authors: Casado‐Bedmar Maite , Heil Stéphanie D. S. , Myrelid Pär , Söderholm Johan D. , Keita Åsa V.
Published: November 2018

Background

Mast cells (MCs) and vasoactive intestinal polypeptide (VIP) have been proposed as regulators of the intestinal barrier and inflammation. Our aim was to map the distribution in inflammatory bowel disease (IBD) and murine colitis.

Methods

MCs, VIP, and VIP‐receptors (VPACs) were quantified by immunofluorescence and enzyme‐immunoassay (EIA) in ileal tissues (villus epithelium (VE) and adjacent VE, ie, VE next to the follicle‐associated epithelium, (FAE)) from Crohn's disease (CD; n = 16) and non‐IBD patients, and in colonic specimens of ulcerative colitis (UC; n = 12) and healthy controls (HCs). In addition, VIP levels were measured in plasma from HCs, non‐IBD, and IBD in remission (CD n = 30; UC n = 30). Colon, ileum, and plasma from mice with dextran sulfate sodium (DSS)‐induced colitis and control mice were analyzed likewise.

Key Results

FAE‐adjacent VE in ileum of CD possessed more MCs (P < 0.05) and MCs expressing VPAC1 (P < 0.05), but not VPAC2, compared to controls. Both adjacent and regular VE of CD had more MCs co‐localizing/in close proximity to VIP (P < 0.05). In UC colon, more MCs (P < 0.0005), MCs close to VIP (P < 0.0005), and MCs expressing VPAC1 (P < 0.05) were found compared to controls. VIP levels were elevated in plasma from CD and UC compared to controls (P < 0.0005). Colon of DSS mice showed more MCs and MCs close to VIP (P < 0.05) compared to control mice. In vitro experiments revealed MCs expressing VPACs and internalized VIP after 120 minutes of VIP‐stimulation.

Conclusions and Inferences

Communication between MCs and VIP is upregulated during IBD and mice colitis. In CD patients, the epithelium next to FAE seems to be more involved than the surrounding VE, suggesting increased MC‐VIP‐interactions in this intestinal region.
Management of Dumbbell and Paraspinal Tumors of the Thoracic Spine Using a Single‐stage Posterolateral Approach: Case Series
Authors: Rong Hong‐tao , Fan Yue‐shan , Li Si‐peng , Zhang Zheng‐shan , Liu Hui , Liu Tong , Zhu Tao , Zhang Jian‐ning
Published: November 2018

This study investigated the surgical results of a single‐stage posterolateral approach with arc incision, unilateral laminectomy, and costotransversectomy for the management of dumbbell tumors and paraspinal tumors of the thoracic spine. From January 2010 to March 2017, 14 patients with dumbbell tumors or paraspinal tumors of the thoracic spine who underwent resection with single‐stage posterolateral approach were followed up and analyzed retrospectively. The operations were performed using a single‐stage posterolateral approach with arc incision, unilateral laminectomy, and costotransversectomy without any instrumentation. We reviewed the scores of clinical symptoms and imaging results, including postoperative MRI and reconstructed 3D‐CT images. Gross total removal was achieved in 13 patients, and subtotal removal was achieved in 1 case. Histopathology revealed schwannoma in 9 patients, angiolipoma in 1 patient, and paraganglioma and mixed hemangioma in 2 patients each. No significant operative or postoperative complications occurred in any patient. The 14 patients were followed up for 14–68 months (mean 39.4 months). At the final follow‐up, no obvious spinal deformity or tumor recurrence was found in any patient except one with paraganglioma. Single‐stage posterolateral approach is a good alternative surgical method for removing dumbbell tumors and paraspinal tumors of the thoracic spine without necessitating a subsequent anterior operation.
Successful long‐term hematological and immunological reconstitution by autologous cord blood transplantation combined with post‐transplant immunosuppression in two children with severe aplastic anemia
Authors: Georgia Avgerinou , Christina Oikonomopoulou , Aikaterini Kaisari , Elda Ioannidou , Anna Komitopoulou , Anna Paisiou , Natalia Tourkantoni , Maria Filippidou , Antonios Kattamis , George Vessalas , Ioulia Peristeri , Evgenios Goussetis , Vasiliki Kitra
Published: November 2018

aUCBT is a valuable curative option in pediatric patients with refractory idiopathic SAA and no available matched sibling or unrelated donors. Experience in the use of autologous cord blood units in patients with SAA is limited and private for‐profit cord blood‐banking programs are controversial. We report the successful treatment of two patients with SAA, aged 15 and 24 months, with autologous cord blood combined with immunosuppression. After conditioning with 200 mg/kg cyclophosphamide and ATG, 7.5 mg/kg, 32.2 × 107/kg, and 3.8 × 107/kg autologous cord blood nucleated cells were infused, respectively. One of our patients underwent transplantation after failure of IST. Both patients received post‐transplant immunosuppression with cyclosporine for 12 months. They remain disease‐free 6 years post‐transplantation.
Respiratory adjuncts to NIV in neuromuscular disease
Authors: Sheers Nicole , Howard Mark E. , Berlowitz David J.
Published: November 2018

Muscle weakness is an intrinsic feature of neuromuscular diseases (NMD). When the respiratory muscles are involved, the ability to take a deep breath is compromised, leading to reduced lung volumes and a restrictive ventilatory impairment. Inspiratory, expiratory and bulbar muscle weakness can also impair cough, which may impede secretion clearance. Non‐invasive ventilation (NIV) is an established and indispensable therapy to manage hypoventilation and respiratory failure. The role of other therapies that support respiratory health is less clearly defined, and the evidence of efficacy is also harder to summarize as the underlying data are of a lesser quality. This narrative review appraises the evidence for respiratory therapies in adults with NMD and respiratory system involvement. Techniques that assist lung inflation and augment cough, such as lung volume recruitment (LVR) and mechanical insufflation‐exsufflation (MI‐E), are a particular focus of this review. The evidence suggests that LVR, MI‐E and various combinations thereof have clinical utility generally, but important methodological limitations limit the strength of clinical recommendations and hamper the integration of evidence into practice. Future trials should prospectively assess the long‐term impact of LVR and cough augmentation on clinical outcomes and burden of care in addition to lung mechanics, as well as determine clear predictors of benefit from these techniques.
Adoption and impact of improved maize varieties on maize yields: Evidence from central Cameroon
Authors: Takam‐Fongang Guy Martial , Kamdem Cyrille Bergaly , Kane Gilles Quentin
Published: November 2018

This study uses both the endogenous switching regression and propensity score matching models to analyze the adoption and impact of improved maize varieties on maize yields in central Cameroon. The results show that (i) education level, agricultural training, proximity to an Institute of Agricultural Research for Development branch and farmers’ perceptions of yield and risk of improved maize varieties significantly affect the adoption of improved maize varieties and (ii) the adoption of improved maize varieties enhances maize yields. Therefore, policies designed to stimulate adoption of improved maize varieties should be promoted. Improvement of access to school and agricultural training may serve as good strategies for promoting the adoption of improved maize varieties in Cameroon.
Flux singularities in multiphase wavetrains and the Kadomtsev‐Petviashvili equation with applications to stratified hydrodynamics
Authors: Ratliff Daniel J.
Published: November 2018

This paper illustrates how the singularity of the wave action flux causes the Kadomtsev‐Petviashvili (KP) equation to arise naturally from the modulation of a two‐phased wavetrain, causing the dispersion to emerge from the classical Whitham modulation theory. Interestingly, the coefficients of the resulting KP are shown to be related to the associated conservation of wave action for the original wavetrain, and therefore may be obtained prior to the modulation. This provides a universal form for the KP as a dispersive reduction from any Lagrangian with the appropriate wave action flux singularity. The theory is applied to the full water wave problem with two layers of stratification, illustrating how the KP equation arises from the modulation of a uniform flow state and how its coefficients may be extracted from the system.
Reassessment of clinical implication of pretransplant surgical procedures for pulmonary invasive fungal lesions
Authors: Shingai Naoki , Kaito Satoshi , Yamada Yuta , Konishi Tatsuya , Nagata Akihito , Kurosawa Shuhei , Watakabe‐Inamoto Kyoko , Igarashi Aiko , Najima Yuho , Muto Hideharu , Kobayashi Takeshi , Doki Noriko , Kakihana Kazuhiko , Sakamaki Hisashi , Ohashi Kazuteru
Published: November 2018

Dealing with the recent series of allogeneic hematopoietic stem cell transplantation (allo‐SCT) performed this decade, we reassessed the clinical impact of pretransplant surgical procedures (SP) for pulmonary lesions of invasive fungal disease (IFD) on subsequent transplant outcome. We focused on the clinical outcomes of seven patients with pulmonary IFD who underwent segmentectomy (n = 4), lobectomy (n = 2) or abscess incision with drainage only (n = 1), and compared results to those of 21 patients carrying pulmonary IFD who never underwent invasive SP before allo‐SCT. The rate of exacerbation of pulmonary lesions by 180 days after allo‐SCT did not differ significantly between groups (32.2% vs 42.9%, P = 0.69). Moreover, no significant differences in non‐relapse mortality (46.4% vs 42.3%, P = 0.93) or overall survival (53.6% vs 30.9%, P = 0.45) at 1 year were evident between groups. These results indicate that pretransplant SP for pulmonary lesions might have no survival benefit under the current antifungal prophylaxis or treatment modality.
Ex vivo cadaveric study of a laterally placed Leipzig stifle distractor for arthroscopic evaluation of the lateral meniscus in dogs
Authors: Götzens Bruno , Medl Susanne C. , Medl Nikola S.
Published: November 2018

Objective

To evaluate safety and accuracy of lateral pin placement for the use of a Leipzig stifle distractor (LSD) and to assess improvements in visualization and treatment of the lateral meniscus in the canine stifle.

Study design

Ex vivo cadaveric study.

Sample population

Paired canine cadaveric hind limbs (n = 10).

Methods

Pins for the LSD were placed from lateral to medial in the distal femur and proximal tibia. Safety and accuracy of lateral pin placement were evaluated via anatomical dissection, computed tomography (CT), and arthroscopy. In every case, distraction of the lateral compartment of the femorotibial joint space was evaluated arthroscopically, and the meniscus was probed. Afterward, the limbs were assigned to 1 of 2 groups, and a partial meniscectomy was attempted with or without distraction. Stifles were disarticulated to evaluate the meniscectomy and iatrogenic cartilage damage.

Results

Computed tomography revealed some variation in pin placement, although sufficient distraction was achieved for all stifle joints. No damage to the surrounding structures was observed during anatomical dissection, CT, or arthroscopy. Disarticulation provided evidence that using an LSD allowed for complete caudal horn meniscectomies and less articular cartilage damage than when meniscectomy was attempted with manual distraction.

Conclusion

Lateral placement of an LSD proved to be safe and effective for the distraction of the lateral femorotibial joint space and the examination and treatment of the lateral meniscus in dogs weighing 18‐42 kg.

Clinical significance

Canine lateral meniscus pathology, although rare, leads to severe pain. A laterally placed LSD improves arthroscopic evaluation and treatment of this pathology.
MORAL VALUES IN THE AMAZING ISLAMIC FAIRY BOOK BY BEBY HARYANTI DEWI AS MATERIAL TEACHING FOR EARLY CHILDHOOD
Authors: Chamalah Evi
Published: November 2018

The literary work contains the values that are beneficial to the reader in his life. In general, the freight values in literature are the value of education, religious values, moral values, social values, and aesthetic value. Moral values as a rule that needs to be enforced in a society because it can be used as guidelines in our daily lives. One form of literature that contains of moral values is a fairy tale. This study is not only talking about the classic fairy tale but also modern fairy tale that has moral value. The Amazing Islamic Fairy Book by Beby Haryanti Dewi is a collection of fairy tales which contains of 34 fairy tales from Islamic countries in three continents. One example of a fairy tale in the collection of these tales teaches about the importance of listening and obeying parents. Based on this background, (1) The author would like to express moral values contained in the Islamic book of fairy tales; (2) can be used as an alternative teaching materials for early childhood literature.
THE RELATION BETWEEN PEDAGOGICAL COMPETENCE, EMOTIONAL INTELLIGENCE AND SELF EFFICACY OF TEACHERS
Authors: Rohimah Siti
Published: November 2018

The purpose of this study to determine: 1) the relationship of pedagogical competence and emotional intelligence and self-efficacy of teachers; 2) the relationship between the pedagogic competence with self-efficacy of teachers; 3) the relationship between emotional intelligence and self-efficacy of teachers; 4) donations or role pedagogic competence, emotional intelligence to the self-efficacy of teachers / study subjects are elementary school teachers in the district Jebres totalled 150 teachers. Collecting data using a scale of pedagogic competence, emotional intelligence scale, and self-efficacy scale. Data were analysed using regression analysis and stepwise two predictors. Based on the calculation, the correlation coefficient R = 0.739, F regression = 88.655; p = 0.000 (p <0.01). These results showed that there was a significant relationship between pedagogical competence, emotional intelligence and self-efficacy of teachers. Results rx1y correlation of R = 0.606, p = 0.000 (p <0.05). Meaning there is a very significant positive between pedagogical competences with self-efficacy of teachers. Correlation analysis rx2y of R = 0.714, p = 0.000 (p <0.05). Meaning there is a very significant positive emotional intelligence and self-efficacy of teachers. The conclusion of this study is that there was a significant relationship between pedagogical competence, emotional intelligence and self-efficacy of teachers. This means that variable pedagogical competence and emotional intelligence can be used as a predictor for predicting self-efficacy of teachers. The variable pedagogical competence contribute 15,3 % to variable self-efficacy while the variable emotional intelligence contribute 39,4%. Therefore structured training is needed to improve teacher’s quality especially in pedagogical competence area.
EFFECT OF BEHAVIOR CONTRACT TO REDUCE MALADAPTIVE BEHAVIORS OF STUDENTS WITH ADHD
Authors: Yusuf Munawir , Nur Aini Zamzammiyah , Sugini Sugini
Published: November 2018

Maladaptive behaviours of students with Attention Deficit Hyperactivity Disorder (ADHD) is negative behaviours, which disturb a learning process in the classroom. This study was conducted to identify the use of the behavior contract in reducing maladaptive behaviors in students with ADHD in Al Firdaus Elementary School Surakarta, Indonesia. Subject of this study was a third grade ADHD student. The Single Subject Research (SSR) with multiple baseline cross variables design was applied as experimental method. The target behaviors were directly observed, recorded in the instrument and analyzed by visual graphic analysis method. At the baseline-1 phase, the target behavior of verbally disrupting friends occured on average 20 times, while nonverbal disruption occured 24 times. The target behavior in the intervention -1 phase tended decrease, with an average of 5 times (verbal) and 4 times (nonverbal). At the baseline-2 phase, the target behavior of interrupting the teacher’s explanation occured on average 18 times. This behavior decreased in the intervention-2 phase with an average of 3 times. At the baseline-3 phase, the target behavior of unable to resist eating and drinking occured on average 10 times. At the intervention-3 phase, the behavior occured on average once. It can be concluded that the behavior contract may reduce maladaptive behaviors of student with ADHD.
THE HARMONIZATION OF PREACHING AND POLITICS OF CONSTITUTIONAL LAW
Authors: Burlian Paisol
Published: November 2018

It is undeniable that Islam is a universal religion which becomes a blessing for the entire universe. Universality of Islam is evident from multi-aspect, a religious aspect, set the life of mankind, and included the inside of preaching and political aspects of constitutional law. This paper examines how, in practice, where the Prophet Muhammad has implemented a law in constitutional politics in line with the guidance of the Quran, especially the Medina period. When in Mecca, the Prophet, as a religious figure, shows preaching secretly and finally in open. However, in Medina, It is clearly seen that there is an integration of the Prophet Muhammad as the religious figure and statesman. While the Prophet still spreads preachings, the Prophet set the Medina becoming a developed country and then Islam can be spread to the world. Their relationship, ideally demonstrated that politics serve as a tool to carry out the mission of preaching. On the other hand, the preaching must also be able to provide an understanding of the political importance of constitutional law for the advancement of religion and the Muslims and not vice versa; stay away from politics because of the wrong perception or manipulate the preaching for political purposes of constitutional law. To ensure that the constitutional law of political activity is not lost, it should be understood that in the politics of constitutional law, there is a law that must be followed, whereas in law, there are the political aspects of constitutional law should be implemented. It will create synergy between preachings and politics of constitutional law for the realization of the Islam’s glory in national as well as in international.
PERSPEKTIF IBN TAIMIYYAH TENTANG AL-TASYABBUH DALAM SAMBUTAN PERAYAAN BUKAN ISLAM(IBN TAIMIYYAH PERSPECTIVE ABOUT AL-TASYABBUH IN THE CELEBRATION OF NON MUSLIM FESTIVAL)
Authors: Ramli Mohd Anuar , Nuba Mohd Sulaiman , Rosele Muhammad Ikhlas , Abdullah Ahmad Badri
Published: November 2018

Socio-cultural interaction has formed transfers, borrowing and cultural imitation between one society to another. This process generates symptoms of sameness or in the jurisprudence terminology it’s called as al-tasyabbuh. Basically not all tasyabbuh are prohibited as long it can contribute a benefit to the Islamic society, while tasyabbuh are not permissible which the symptoms that can harm the Islamic society, such as the imitation of non-Muslim way of life, their festivals and customs practices. This imitation will eradicate the identity of Islamic society. Therefore, this research will discuss about the perspective of Ibn Taymiyyah on tasyabbuh upon his work on Iqtida' al-Sirat al-Mustaqim Mukhalafah li Ashab al-Jahim. In most of the discussion of his work, Ibn Taymiyyah focuses on al-tasyabbuh in the issues which related to the practice among Muslims and non-Muslims. He explores the interpretation of the verses of the Qur'an, Hadith and athar of the Companions which parallel with tasyabbuh. It was found that he had a fixed and rigid perspective according to imitate (tasyabbuh) the non-Muslims, especially in their religious aspects.
BAI’-AL-INAH MENURUT MUAMALAT- ANALISIS DARI PERSPEKTIF PERISIAN APLIKASI (BAI'-AL-INAH: AN ANALYSIS FROM SOFTWARE APPLICATION PERSPECTIVE)
Authors: Hehsan Nurshuhadak , Salamon Hussin
Published: November 2018

The concept of Bai 'Al-Inah is one kind of Islamic banking loan products adopted by several Islamic financial institutions in Malaysia. Bai 'Al-Inah terms and in the context of Islamic banking is selling to raise cash immediately (immediate cash-facility). However, it is a scheme application status is still disputed by the ulama’ salaf among modern Muslim world. Research should be viewed from the aspect of both the extent to which differences of view and to what extent the adoption and implementation of these concepts are implemented according to the principles of Muamalah Fiqh. In this study, the author is looking at the performance in terms of technical (software Bai 'Al-Inah) that have been adopted so far by Islamic financial institutions in Malaysia. Selection of the concept of Bai’ Al-Inah chosen for being the highest services offered by Islamic banking institutions and is the main service subscribed by the people of Malaysia. Although the Shariah Advisory Council of Central Bank of Malaysia (BNM) has been to try and make sure to constantly keep all that felt inappropriate to claim Muamalah Fiqh. However, this does not mean that Islamic financial institutions in Malaysia are now complete for the study authors on some of the existing terms and conditions in this service is still exist some practices that conflict with the claims Muamalah Fiqh. Finally, the paper work to see the constraints that exist and make recommendations and suggestions for improvement and the reference to be updated in the future for the development of Islamic banking in Malaysia in particular and the Muslim world in general.
PEMIKIRAN DAN SUMBANGAN FETHULLAH GULEN DALAM DIALOG ANTARA AGAMA (THE THOUGHT AND CONTRIBUTION OF GULEN FETHULLAH IN INTERFAITH DIALOGUE)
Authors: Ramli Ahmad Faizuddin
Published: November 2018

The correlation between religion, race, and culture lead to the establishment of human civilisation. Peoples from different background were able to have mutual understanding and develop harmonious society. Primarily, spiritual practices empower this civilisation and create perfect soul. A distinguished scholar named Fethullah Gulen is a leading scholar of his own theories in inter-religious dialogue local and international context. This article aims to discuss on the ideas of Fethullah Gulen especially relates to the interfaith dialogue. This is a qualitative research where it applies literature review as its method and design. The outcome of this research is the thought of Fethullah Gulen in inter-religious dialogue influenced by Said al-Nursi (the leaders of the Turkish-Islamic thinker). The approach of Said and Fethullah highlights element of tolerance and mutual dialogue. Fethullah Gulen movement appears to be more active through education using distinctive mediums of ideas.
AMALAN BERSEDEKAH DALAM KALANGAN GURU PENDIDIKAN ISLAM PRASEKOLAH (THE PRACTICE OF ACT OF GIVING AMONG THE PRESCHOOL ISLAMIC EDUCATION TEACHERS)
Authors: Mohamed Sofiah
Published: November 2018

The purpose of this study is to explore the practice of giving teachers in teaching and learning (PdP) Islamic education preschool. Preschool is the level of early childhood in Malaysia following the curriculum provided by the Ministry of education (MOE). These are the primary education in an effort to educate the younger generation successor race so as to have the knowledge, moral and have a strong resilience. A total of four study participants are selected based on criteria, which taught Islamic Education Curriculum Standard National preschool (KSPK), attend courses organised by KPM, teaching the subjects of Islamic Education Preschool for more than three years, and be prepared and agreed on a voluntary basis for observed, interviewed, and analysed documents. Data for the qualitative study collected through triangulasi between the techniques of observation data, interviews, and analysis of documents. The data collected was subsequently analyzed using Nvivo software version 11. The findings show that occur multiple application of moral values in the PdP Islamic education Preschool. Teachers also adopt these elements through a variety of ways. The teacher makes the practice of gift giving to pupils as one applications of charity as well as techniques improve motivation to learn. This study resulted ‘Preschool Teacher in Charity Practices Model’ that can provide guidance and expected benefits to parents, teachers, curriculum makers especially to all parties involved with early childhood education. This finding also expected a positive impact to produce the next generation of great starting from pre-school to higher education.
Law Enforcement Response To Human Trafficking According To Law No. 21/2007: Case Study in Benjina, Aru Archipelago Regency
Authors: Fikri Pandela Ahmad Ali , Ansyory Anhar , Ulfatmi Ulfatmi
Published: November 2018

Generally, there are some distinction on the response to human trafficking that has been particularly ruled in Law No.20/2007 21 about Abolition of Criminal Act Human Trafficking. That law contains legal basis to anticipate and round up activities, ways, or any other exploitations occured on human trafficking. In the process of implementation of criminal act case handling to human trafficking, the peace officer sometimes get difficulties to proof the perpetrator because sometimes it’s an organized crime, moreover it is a trans-national crime. The purpose of this study is to know and to analyze some aspects in law enforcement on human trafficking cases in Indonesia according to Law No. 21/2007 about Abolition of Criminal Act Human Trafficking (case study on human trafficking case in Benjina, Aru Archipelago Regency, and Maluku). So that this study can be a common comprehensive study to handle the human trafficking cases in Indonesia.
Interreligious Dialogue: From Coexistence To Proexistence (Understanding The Views of Mukti Ali and Hans Kung)
Authors: Basuki Singgih
Published: November 2018

The present and future worlds are pluralistic. Globalization has a direct effect on all aspects of human life, including religious patterns. The life of religious people in this global world should have a proper vision of their religion and other communities with a positive awareness of diversity. Each community should be aware of the existence of its own group and other groups with all the differences. Herein lies the importance of interreligious dialogue. Initially, the purpose of the interreligious dialogue is to foster pluralistic awareness of tolerance (co-existence) so that people can live together peacefully; however, the present and future dialogues must be actively involved in inter-religious cooperation programs (co-existence) to solve humanitarian problems. Among the initiators of the interfaith dialogue in the context of global life are Mukti Ali and Hans Kung. Although their intellectual and theological base is different, they both share a common vision, mission and a great agenda of interfaith dialogue in order to achieve a dynamic peace.
The Impact of Islam on The Concept of Government of The Sultanate of Malacca During The 15th Century
Authors: Mamat Ismail
Published: November 2018

This article attempts to look at the impact of Islamization process on the Sultanate of Malacca during the 15th century. Islam has offered civilizational life for the Malays. Malacca grew from an unknown place during the pre-Islamic period to become one of the well-known centres of Islamic religion and culture in the region. Islam has changed the status of Malacca after reducing its pre-Islamic customs and ways of life. The importance of the Malay Sultanate of Malacca has been well-documented and much has been written about it by many authors either by Malaysians such as Buyong Adi1, Kernal Singh Sandhu, Mohd Jamil Mukmin, Mohd Taib Osman, Muhammad Yusoff Hashim, Abu Hassan Sham, Khoo Kay Kim, and Joginder Singh Jessy, and Zubir Usman, or by the non-Malaysians including R. O. Winstedt, R. J. Wilkinson, Walter William Skeat, C. O. Blagden, Paul Wheatley, D. G. Hall, F. J. Moorhead, J. Bantin and R. Roolvink, J. Kennedy, John Bastin, Liang Liji, M. B. Hooker, Nicholas Tarling, Paul Wheatley, Sarnia Hayes Hoyt, T. W. Arnold, W. P. Groeneveldt, Christoper H. Wake,  P. E. de Josselin de Jong and H. L. A van Wijk, Robert W. McRoberts, and Wang Gangwu. They wrote on various genres of literature and culture of the Malays as well as the history of the Sultanate. However, some of them especially the orientalists, because of their adoption of various Western social theories, this application of such theory to the sultanate or the Malay society yield untenable results. We shall argue some of whom tend to regard Islam as unimportant in shaping the Malay worldview, society and identity. This article will emphasize the civilizational significance of the Islamic impact by looking at the system of political authority and the concept of government of the Sultanate.
Ketokohan Tn. Hj. ‘Abdullah Al-Qari Bin Hj. Salleh (‘AQHAS) Sebagai Tokoh Mufassir Tematik Di Malaysia
Authors: Abdul hadi Ahmad Zulfiqar Shah , Abd Latif Mohd Abdul Nasir , Abdul Rahman Muhammad Hasbi
Published: November 2018

The Thematic's interpretation of Al Quran (Mawdu'i) is a new approach of Islamic scholars to break through in the context of interpreting al-Qur'an al-Karim, including in Malaysia. One of the writers who wrote vastly in the context of Thematic’s interpretation of Al Quran (Mawdu'i) was Mr. Hj. 'Abdullah al-Qari bin Hj. Salleh ('AQHAS). Based on the study, a total of 56 of his works have been produced in the context of the Thematic Interpretation so that he is entitled to be called a Quranic thematic interpreter. Hence, this study is aimed at highlighting information on the interpreter’s credibility, the credibility to fulfill his manners and conditions as an interpreter and his works before he can be called an interpreter. In order to achieve this goal, the method of interviews and documentation of related materials are used. The results found that 'AQHAS through his thematic works has benefited the community; a more focused and appropriate understanding of reading for those who want to learn the Quranic knowledge. It is hoped that this information will highlight the personality and accreditation of local scholars in the Quranic interpretation.