bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of maternal HLA-DR and HLA-G loci in determining the risk of sporadic congenital heart defects in the next generation
Authors: Deeva N. S. , Tsepokina A. V. , Shmulevich S. A. , Shabaldin A. V.
Published: December 2021

The paper considers the role of maternal HLA-DR (Human Leukocyte Antigens-DR) and HLA-G (Human Leukocyte Antigen-G) loci in determining the risk of the formation of sporadic congenital heart defects without chromosomal diseases in the next generation. The HLA-G molecule expressed on trophoblast performs a protective function by blocking killer receptors on natural killer cells (NK cells). At the same time, the maternal alleles of HLA-DRB1 restrict the immune response to allogeneic antigens of the paternal embryo, which may affect the severity of inflammation in the mother-embryo system and through this mechanism induce the formation of heart disease.

Objective: to study the frequency distribution of the combinations of alleles and genotypes of HLA-G 3’UTR and HLA-DRB1 in women with children with sporadic congenital heart defects without chromosomal diseases. Children characteristics and research methods. There were formed 2 groups: Main Group (103 women with children with sporadic congenital heart defects without chromosomal diseases) and Control Group (103 women with conditionally healthy children). Genomic DNA was isolated by phenol-chloroform extraction. Typing of HLA-G 3’UTR 14-bp insertion/deletion was performed by amplification of polymorphic regions of genes by polymerase chain reaction with further electrophoretic detection in polyacrylamide gel 6.0. The frequency analysis of 14 alleles of the HLA-DRB1 gene was performed by real-time polymerase chain reaction. In the course of this work the authors identified predictor and protective combined genotypes.

Conclusion. HLA-DRB1 and HLA-G 3’UTR 14-bp ins/del (rs 1704) make a significant contribution to determining the risk of the formation of sporadic congenital heart defects without chromosomal diseases in the next generation.
Risk factors for the development of intraventricular hemorrhage in preterm infants with respiratory distress syndrome
Authors: Andreev A. V. , Kharlamova N. V. , Shilova N. A. , Pesenkina A. A.
Published: December 2021

Intraventricular hemorrhage remains a serious complication in infants and especially in preterm infants with gestational age up to 27 weeks.

Objective. To assess the risk factors for the development of intraventricular hemorrhage in deeply preterm infants with respiratory distress syndrome.

Materials and methods. We carried out a prospective controlled comparative study. The study included 104 newborns with respiratory distress syndrome with a gestational age of less than 32 weeks and a birth weight of less than 1500 g. Depending on the presence of intraventricular hemorrhage the patients were divided into groups: Group I : 56 preterm infants with intraventricular hemorrhage verified during the observation; Group II: 48 preterm infants without intraventricular hemorrhage

Results. The groups at birth were comparable in terms of weight and height. We identified the risk factors contributing to the development of intraventricular hemorrhage: the absence of antenatal prophylaxis of fetal respiratory distress syndrome (odds ratio (OR) 2.728; 95% CI 1.218–6.109), tracheal intubation in the delivery room (OR 5.714; 95% CI 1.610–20.28), the need for mechanical ventilation on the first day life (OR 2.713; 95% CI 1.154–6.377), forced mechanical ventilation (OR 9.818; 95% CI 1.039–92.86), > 20 manipulations in the first day of life (OR 2.747; 95% CI 1.240–6.089). Also, the authors determined the factors contributing to a decrease in the development of intraventricular hemorrhage: complete antenatal prevention of fetal respiratory distress syndrome (OR 0.35; 95% CI 0.149–0.825), less invasive administration of poractant-alpha at a dosage of 200 mg/kg (OR 0.161; 95% CI 0.033–0.787), ventilation with double control during inspiration (OR 0.159; 95% CI 0.032–0.784), chronic arterial hypertension in the mother during the present pregnancy (OR 0.185; 95% CI 0.037–0.919).

Conclusion. According to the results of the study the authors identified significant risk factors for the development of intraventricular hemorrhage in deeply preterm infants with respiratory distress syndrome.
Validation and Application of a Methodology for Quantifying Levels of Parabens in Sports Supplements from Brazil Using Liquid Chromatography-Mass Spectrometry
Authors: Rocha Bruno , Cesila Cibele , Martins Airton , Souza Marília , Barbosa Jr. Fernando
Published: December 2021

Although parabens have been reported to be used as antimicrobial preservatives in personal care products, pharmaceuticals, and foodstuffs, little is known about the occurrence of these compounds in sports supplements. In this study, a simple, fast and sensitive liquid chromatography tandem mass spectrometry method for simultaneous determination of five commonly used parabens, methyl-, ethyl-, propyl-, butyl-, and benzylparaben in sports supplements was established. The analytical method was validated with the values of parameters being acceptable. The method proved reliable, accurate, and sensitive and was successfully applied for the quantitation of parabens in 85 sports supplements samples. Almost all sports supplements contained at least one of the parabens analyzed, and the total concentrations of five parabens ranged from below the limit of quantification to 145 μg g-1, with a median value of 0.171 μg g-1. Ethylparaben and methylparaben were the most frequent paraben analogs found in samples (detection rate > 60%). Propylparaben, butylparaben and benzylparaben are forbidden in food samples, their detection rates were 49.4, 21.2 and 4.7%, respectively. Therefore, our study suggests that Brazilian population may be exposed to estrogenic not allowed parabens and their harmful effects through the intake of sports food supplements.
A TRAJETÓRIA E ATUAÇÃO DO SUBPROJETO DE CIÊNCIAS SOCIAIS: O PIBID DA UFRN
Authors: DIAS SALES SALES, Ana P. Dias; SOUZA,Flora Assaf de Patrícia
Published: December 2021

Este artigo analisa a trajetória e atuação do subprojeto Ciências Sociais do Programa Institucional de Bolsa de Iniciação à Docência (PIBID), da Universidade Federal do Rio Grande do Norte (UFRN), no período de 2014 a 2017. A pesquisa foi desenvolvida na UFRN e em escolas parceiras do programa, e se valeu dos dados primários oriundos das etnografias elaboradas pelos bolsistas do programa, da observação participante e de entrevistas semiestruturadas com ex-pibidianos e discentes da licenciatura em Ciências Sociais. Como resultado, percebeu-se que as propostas metodológicas de divisão por distintos subgrupos e as sequências didáticas, estratégias adotadas pelo subprojeto Ciências Sociais, potencializam a formação docente ao fazer dos participantes os protagonistas deste processo. Assim, o PIBID alcança um de seus principais objetivos, que é o aperfeiçoamento da formação docente por meio da construção de metodologias inovadoras.
Изучение эффективности психотерапевтических методов в разных возрастных группах тревожных детей и подростков
Authors: Бартош Ольга П. , Бартош Татьяна П.
Published: December 2021

Введение. Психическое здоровье молодого поколения является одной из актуальных задач современного мира. Новизна данного исследования состоит в изучении влияния различных психотерапевтических методов на тревожность детей и подростков. Методы. Приняли участие 83 учащихся школ в возрасте 7–16 лет. Тревожность оценивали с помощью проективного теста Р. Тэммл, М. Дорки, В. Амен (группа I), «Многомерной оценки детской тревожности» (МОДТ, группы II–IV) и шкалы Спилбергера – Ханина (группа V). Использовали психотерапевтические методы: когнитивно-поведенческий тренинг (КПТ), метод биологической обратной связи (БОС), песочную терапию и сказкотерапию. Результаты. Исследование у первоклассников 7,1 ± 0,07 лет (группа I) показало значимое (p < 0,01) снижение тревожности на 1,6 балла после психокоррекционного курса. В группе II (9,3 ± 0,14 лет) наблюдалось снижение значений тревожности по шкалам МОДТ 1, 2, 5, 6, 7, 9 и 10 на 1,5–4 балла (p < 0,01). У школьников группы III (10,5 ± 0,09 лет) отмечено значимое уменьшение тревожности на 0,5–2 балла по шкалам опросника – 1, 3, 4, 7, 10. В группе IV (12,4 ± 0,11 лет) после 8 месяцев КПТ произошло снижение тревожности по 9-ти шкалам МОДТ на 1–3 балла (p < 0,01). За 1,5 месяца занятий БОС в группе V (15,5 ± 0,17 лет) у подростков было достигнуто значимое уменьшение показателей ситуативной и личностной тревожности до умеренных величин. Обсуждение результатов. Большое напряжение у школьников вызывают ситуации проверки знаний и самовыражения, тревога в связи с оценкой окружающих. В целом применение любых психотерапевтических методов является эффективным способом, который снижает тревожность у детей и подростков, улучшает их эмоциональное состояние и школьную адаптацию.
Formação contínua para professores sem formação pedagógica: um estudo de caso com professores de Educação Física da Escola Primária n. 74 Dangereux, na Província de Malanje-Angola
Authors: Cabamba João Isarael , Yanes-Cabrera Cristina , Ballesteros-Moscosio Miguel Ángel
Published: December 2021

A Educação Física é uma disciplina composta por atividades físicas planejadas e estruturadas com o propósito de melhorar a saúde física, e a docência nesta área requer formação profissional assim como nas demais áreas do conhecimento. O objetivo deste artigo foi analisar as competências pedagógicas dos professores de Educação Física de uma escola primária no município de Malanje, em Angola. Para tanto, utilizou-se uma abordagem quali-quantitativa por meio da aplicação de questionário, observação e entrevista a oito professores, 29 alunos e a diretora da escola. Constatou-se a presença de professores sem formação específica conduzindo as aulas de Educação Física, alunos desmotivados e uma direção empenhada em fortalecer seu corpo pedagógico tendo em vista o perigo em potencial que profissionais despreparados podem causar tanto aos alunos como para a Escola. Por estes motivos, este artigo propôs um programa de formação contínua aos professores a fim de melhor prepará-los para seus cargos.
Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease
Authors: Onyango Isaac G. , Bennett James P. , Stokin Gorazd B.
Published: December 2021

Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disease and
the most common cause of dementia among older adults. There are no effective treatments available
for the disease, and it is associated with great societal concern because of the substantial costs
of providing care to its sufferers, whose numbers will increase as populations age. While multiple
causes have been proposed to be significant contributors to the onset of sporadic AD, increased age
is a unifying risk factor. In addition to amyloid-β (Aβ) and tau protein playing a key role in the initiation
and progression of AD, impaired mitochondrial bioenergetics and dynamics are likely major
etiological factors in AD pathogenesis and have many potential origins, including Aβ and tau. Mitochondrial
dysfunction is evident in the central nervous system (CNS) and systemically early in the
disease process. Addressing these multiple mitochondrial deficiencies is a major challenge of mitochondrial
systems biology. We review evidence for mitochondrial impairments ranging from mitochondrial
DNA (mtDNA) mutations to epigenetic modification of mtDNA, altered gene expression,
impaired mitobiogenesis, oxidative stress, altered protein turnover and changed organelle dynamics
(fission and fusion). We also discuss therapeutic approaches, including repurposed drugs,
epigenetic modifiers, and lifestyle changes that target each level of deficiency which could potentially
alter the course of this progressive, heterogeneous Disease while being cognizant that successful
future therapeutics may require a combinatorial approach.
Textile Based Electrodes for Flexible Lithium-ion Batteries: New Updates
Authors: Alahmed Ahmed , Sabir Emel Ceyhun
Published: December 2021

:

The electrodes are the basis for building flexible lithium-ion batteries (FLIBs), and
many attempts have been made to develop flexible electrodes with high efficiency in terms of
electrical conductivity, chemical and mechanical properties. Most studies showed relatively
satisfactory results when testing the electrochemical properties of laboratory-produced electrodes,
but most of these electrodes could not meet the expected requirements of flexible electrodes
in practical applications. Quantitative production faces many problems that must be overcome,
such as the gradual decline in electrochemical performance, deformation of the electrode
structure, high production costs, and difficulties in the production process itself. In this research,
developments in the production of flexible electrodes, especially those that depend on carbon
materials and metal nanoparticles, will be discussed and summarized in this research. The electrochemical
performance and stability of the produced flexible electrodes will be compared. The
factors contributing to the progress in the production of flexible lithium-ion batteries will also be
discussed.
miR-27b-3p is Highly Expressed in Serum of Patients with Preeclampsia
and has Clinical Significance
Authors: Yang Yang , Tang Fang , Zhao Xuezhi
Published: December 2021

Background:

Preeclampsia (PE) is defined as a salient complication of late pregnancy.
microRNAs (miRNAs) have emerged as critical biological regulators in PE. This study determined
miR-27b-3p expression in serum of PE patients and investigated its clinical significance in PE.

Methods:

This study enrolled a total of 130 pregnant women, including 90 PE patients (51 mild PE
and 39 severe PE) and 40 healthy controls. miR-27b-3p expression in the serum of PE patients and
healthy controls was detected using RT-qPCR. The correlation among miR-27b-3p expression and
24-h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine,
and fetal birth weight was analyzed using Pearson's correlation coefficient. The targeting relationship
between miR-27b-3p and PPARG was verified. PPARG protein level in PE patients was
detected using ELISA kits. The predictive efficiency of miR-27b-3p and PPARG in PE was analyzed
using the receiver operating characteristic (ROC) curve.

Results:

Compared to normal pregnant women, PE pregnant women, especially severe PE patients,
had higher miR-27b-3p expression. miR-27b-3p was positively correlated with 24-h urine protein,
SBP, DBP, and serum creatinine but negatively correlated with fetal birth weight. PPARG was
poorly expressed in PE patients and negatively correlated with miR-27b-3p. ROC curve showed
that both miR-27b-3p and PPARG had good predictive efficacy on PE.

Conclusion:

miR-27b-3p expression in serum of pregnant women with PE was positively correlated
with the severity of PE symptoms, suggesting the involvement of miR-27b-3p in PE occurrence.
Mutual interaction between literature and architectural space
Authors: Ainash Nauryzbayeva , Yussupova Ardak , Nurpeiis Moldir , Sadvokasova Gaukhar , Trofimov Victor , Myrzakhmetova Saltanat
Published: December 2021

Examples of the interaction of literature and architectural space are considered in this article. The considered examples demonstrate the role of literature in solving various architectural problems. For example, social tasks related to the safety of the urban environment, in the creation of a unique image of the city, the development of stylistic trends, environmental problems. Human perception of architectural space, described in the literature, can make an invaluable contribution to scientific research in the social and humanitarian direction. The description of architectural spaces allows us to identify the level of comfort, the influence of architectural objects and landscape on people, the correspondence of the urban environment to the worldview of the townspeople. Both directions have huge scientific potential in research activities. The result of this research is the interpretation of the literary description of the subject environment of applied folk art in a modern interior. The architectural space has a scenic character reflecting the literary descriptions of the yurt's interior. This approach can be used as the main direction in the development of the concept of architectural spaces for different functional purposes. This article examines an example of a kindergarten organized according to the principle of "the walls teach".
Corona delta varian news text: critical discourse analysis on TV talkshows’ head line
Authors: Tampubolon Sahlan , Sipayung Kammer , Napitupulu Fenty Debora , Sidabutar Usman
Published: December 2021

Objectives: This study is about the realization of critical discourse analysis on TV talkshows’ headlines about corona delta variant. Methods: The data was gathered by collecting 31 headline news stories about Corona from three TV channels: Metro TV, TV One, and Kompas TV. Result:  The result showed that at the level of micro, the linguistic features used by the three TV channels were dominated by expressing declarative ideas. On the level of macro, the three TV channels used facts as information and statements as information. On the level of meso, it was discovered that the three TV channels used their roles as public behavior influencers, information providers, policy evaluators, and socialization agencies. The conclusion: the ideology of the TV channel influences the way of delivering news CDA, coronavirus delta variant news, TV talk shows.
Code and messages interpretation on COVID-19 street banner
Authors: Lestari Febrika Dwi , Simarmata Rina Octavia , Sitorus Nurhayati , Sidabutar Usman
Published: December 2021

COVID-19 Street banner is one of various ways and medias used for communicating and informing about the virus that contain of whether invitation, prohibition, or strategies to reduce the spread of Corona virus outbreak to society. Based on an interdisciplinary theoretical framework, this study revealed to the genaral understanding of the COVID-19 banners and how this media contribute to the overcoming of the pandemic spreading. In order to examine and explain the interpretations and influences of this media associated with the awareness and information on how to reduce the COVID-19 outbreak through the images and verbal signs of the banner, this present work analyzed COVID-19 street banner that circulated on the street and building around Medan to Binjai about COVID-19. The study employed the theories of social semiotics by using Barthes theory with descriptive visual study design approach to reveal the code and message of the banner. The result showed that those banners conveyed the similar message that doing the heath protocols are able to reduce the spreading of the virus and they have special effect on society. Government ministry and various organizations worked together to educate and encourage society about COVID-19 through street banners as their communicative strategy.
An exemplary way of life
Authors: Urinbaevna Sariboeva Maxsuda , Urihbaevna Saribaeva Maksuda
Published: December 2021

This article describes the life and work of our countryman, englightener, poet-patriot Ishoqkhon Tura Ibrat on the basis of new sources.  The is analysis of educational and upbringing aspects of some his works. Today it is important to study the lives and pedagogical activities of our scientists, modern teachers, who in the history of our people have exemplary service to the development of pedagogy, studying the laws, rules and methods of educating young people and educating them in the spirit of being able to contribute to the development of the country.  is one of the tasks.  From this point of view, Ishakhon Ibrat is a great representative of our generation, who called young people to acquire knowledge and make a good name.
The relationship between planned behavior family factors and intention to study abroad
Authors: Nguyet Nguyen Anh
Published: December 2021

This study explores the relationship between planned behaviour, i.e. attitude towards behaviour, subjective norm and perceived behavioural control and coherence towards intention to enrich the literature - Vietnamese students studying abroad at university. In addition, the study also explores the factors related to family cohesion to the intention of Vietnamese students to study abroad. This study was conducted through a cross-sectional survey using a targeted sampling technique (n=350). The SEM model was used to test the hypotheses. The SEM model proved that: The decisive factor affects the intention to study abroad with the coefficient of Regression Weight = 0.222. The subjective norm factor (norm) affects the intent variable with the coefficient of Regression Weight = 0.138; The behavioural intention control factor affects the intent factor with Regression Weights = 0.276; The factor through family cohesion (cohesion) affects the intent factor with Regression Weights = 0.159. The conclusions of this study provide valuable data for study abroad managers, universities, study abroad consulting service providers and families who want to invest in their children to study abroad.
O grafema e o dígrafo um estudo longitudinal do desempenho ortográfico de crianças de três dialetos portugueses
Authors: Gomes Jéssica , Rodrigues Celeste
Published: December 2021

e possible preservation of the phonological distinction between the voiceless post-alveolar affricate /tS/ and the voiceless post-alveolar fricative /S/ - corresponding to the graphic forms  and , respectively - in only a few dialects in the north of the country could be motivating different behaviors from children speaking different regional varieties of Portuguese in their first years of schooling. Since this study has not yet been done, this paper intends to analyze the written productions of Portuguese children from three linguistic areas of Portugal, represented here by children from the cities of Lisbon, Porto, and Chaves, about the spellings  and , to understand whether there is any relationship between the preservation or non-preservation of this phonological distinction and the children’s orthographic performance. Thus, the written productions of students belonging to the three dialectal regions mentioned above will be analyzed based on data from the EFFE-On corpus (Rodrigues, Lourenço-Gomes, Alves, Janssen & Gomes 2015) with the phonological distinction between /tS/ and /S/ having been preserved in some and neutralized in others. Therefore, it will be possible to measure the impact that the students’ dialect can have on their orthographic performance, as well as perceive any differences in performance related to the grapheme  vs. the digraph . Two groups of children were created for the analysis: a group with typical and another with atypical phonological development children. The differences observed point to a need to deepen the discussion concerning the sound aspect of language in the classroom, beginning in the first years of schooling - especially during the literacy phase.
Palyatif Bakım Hastalarında Ağrı Düzeyi ile Genel Konfor Arasındaki İlişkinin İncelenmesi
Authors: MENEKLİ Tuğba , DOĞAN Runida , ŞENTÜRK Sibel
Published: December 2021

Amaç: Bu araştırmanın amacı, palyatif bakım hastalarında ağrı düzeyi ile genel konfor arasındaki ilişkinin incelenmesidir. Yöntem: Çalışma, Mart 2019-Şubat 2020 tarihleri arasında kamuya ait bir hastanenin palyatif bakım kliniklerinde yatarak tedavi gören 18 yaş ve üzerinde olan, bilinci yerinde olan, sözel iletişime açık, Palyatif Performans Skoru %40 ve üzerinde bulunan ve çalışmaya katılmayı kabul eden 358 hasta ile tamamlanmıştır. Veriler, Kişisel Bilgi Formu, Palyatif Performans Skalası (PPS), Kısa McGill Melzack Ağrı Soru Formu (K-MASF) ve Genel Konfor Ölçeği (GKÖ) ile toplanmıştır. Verilerin değerlendirilmesinde Independent Sample t testi, One-Way ANOWA, Pearson Korelasyon ve Linear Regresyon analizi kullanılmıştır. Bulgular: Araştırmaya katılan hastaların yaş ortalaması 38.76±8.90 yıl, %53,4’ünün erkek, %29,6’sının kanser hastası, %39,7’sinin hastanede yatış süresinin 4-6 gün olduğu ve %70,7’sinin ağrı nedeniyle günlük yaşamlarının etkilendiği saptanmıştır. Hastaların %21,2’sinin ağrı bölgesinin baş/ekstremite, %24,3’ünün ağrı niteliğinin zonklama, %36,6’sının genel ağrı şiddetinin berbat, %45,3’ünün ağrısının zamanla ilişkisinin Ritmik-Periyodik-Aralıklı olduğu saptanmıştır. Araştırma sonucunda, hastaların ağrı şiddetinin 8,01±0,52, genel konfor ölçeği toplam puan ortalamasının ise 1,87± 0,11 olduğu belirlenmiştir. K-MASF ve GKÖ arasında yüksek düzeyde negatif yönlü bir ilişki bulunduğu saptanmıştır (p<0,05). Sonuç: Bu araştırmada, palyatif bakım hastalarında ağrı düzeyinin artmasının genel konfor düzeyini azalttığı saptanmıştır.
Исследование плазмонного резонанса в Bi-=SUB=-2-=/SUB=-Se-=SUB=-3-=/SUB=- и Sb-=SUB=-2-=/SUB=-Te-=SUB=-3-=/SUB=- методом инфракрасной спектральной эллипсометрии
Authors: Ализаде Э.Г.
Published: December 2021

In the infrared region of the spectrum (IR), the optical properties of single-crystal samples of narrow-gap degenerate semiconductors Bi2Se3 and Sb2Te3 are investigated by infrared spectral ellipsometry (SE). The transport properties of the Drude fitting of dielectric functions obtained by spectroscopic ellipsometry are studied. The behavior of the bulk and surface plasmon polaritons is investigated in detail. The dispersion and mean free path of the plasmon, the depth of the skin layer for the conducting and dielectric surfaces are calculated. The contribution of the plasmon to the optical properties is estimated from the spectral density for the Bi2Se3 and Sb2Te3 samples.
О площади предельно коротких электромагнитных импульсов в среде для задач конечной области интегрирования
Authors: Николаев В.Г.
Published: December 2021

Исходя из одномерных уравнений Максвелла электродинамики сплошной среды, получены балансные соотношения электрических и магнитных площадей для задач, решаемых в конечной области по пространству и по времени. Ключевые слова: предельно короткие импульсы, электрическая площадь импульса.
Mobile Intervention to Improve Sleep and Functional Health of Veterans With Insomnia: Randomized Controlled Trial
Authors: Reilly Erin Dawna , Robinson Stephanie A , Petrakis Beth Ann , Gardner Melissa M , Wiener Renda Soylemez , Castaneda-Sceppa Carmen , Quigley Karen S
Published: December 2021

Background

Insomnia is a prevalent and debilitating disorder among veterans. Cognitive behavioral therapy for insomnia (CBTI) can be effective for treating insomnia, although many cannot access this care. Technology-based solutions and lifestyle changes, such as physical activity (PA), offer affordable and accessible self-management alternatives to in-person CBTI.

Objective

This study aims to extend and replicate prior pilot work to examine whether the use of a mobile app for CBTI (cognitive behavioral therapy for insomnia coach app [CBT-i Coach]) improves subjective and objective sleep outcomes. This study also aims to investigate whether the use of the CBT-i Coach app with adjunctive PA improves sleep outcomes more than CBT-i Coach alone.

Methods

A total of 33 veterans (mean age 37.61 years, SD 9.35 years) reporting chronic insomnia were randomized to use either the CBT-i Coach app alone or the CBT-i Coach app with a PA intervention over 6 weeks, with outcome measures of objective and subjective sleep at pre- and posttreatment.

Results

Although the PA manipulation was unsuccessful, both groups of veterans using the CBT-i Coach app showed significant improvement from baseline to postintervention on insomnia (P<.001), sleep quality (P<.001), and functional sleep outcomes (P=.002). Improvements in subjective sleep outcomes were similar in those with and without posttraumatic stress disorder and mild-to-moderate sleep apnea. We also observed a significant but modest increase in objective sleep efficiency (P=.02).

Conclusions

These findings suggest that the use of a mobile app–delivered CBTI is feasible and beneficial for improving sleep outcomes in veterans with insomnia, including those with comorbid conditions such as posttraumatic stress disorder or mild-to-moderate sleep apnea.

Trial Registration

ClinicalTrials.gov NCT03305354; https://clinicaltrials.gov/ct2/show/NCT03305354
Evaluation of the Pathways for Survivors Program to Address Breast Cancer Survivorship–Associated Distress: Survey Study
Authors: Umashankar Saumya , Mamounas Matina Elise , Matthys Madeline , Hadeler Edward Kenji , Wong Emily Claire , Hicks Greg , Hwang Jimmy , Chien Amy Jo , Rugo Hope S , Hamolsky Deborah , Esserman Laura , Melisko Michelle
Published: December 2021

Background

Patients with breast cancer frequently experience escalation of anxiety after completing curative treatment.

Objective

This study evaluated the acceptability and psychological impact of a 1-day workshop to emphasize behavioral strategies involving intention and self-efficacy.

Methods

Breast cancer survivors who attended a 1-day Pathways for Survivors workshop provided feedback and completed electronic quality of life (QOL) questionnaires at baseline, 1 and 6 weeks, and 6 months after the workshop. Attendees’ baseline QOL scores were compared to follow-up (FUP) scores. Scores from patients receiving routine FUP care were also compiled as a reference population.

Results

In total, 77 patients attended 1 of 9 workshops. The mean satisfaction score was 9.7 out of 10 for the workshop and 9.96 out of 10 for the moderator. Participants’ baseline mean Patient-Reported Outcomes Measurement Information System (PROMIS) anxiety and depression scores were 57.8 (SD 6.9) and 55.3 (SD 7.5), respectively, which were significantly higher than those of patients receiving routine FUP care (49.1, SD 8.3 and 47.3 SD 8.0, respectively). PROMIS anxiety and depression scores decreased, and the Happiness Index Profile (HIP-10) score—measuring intention and resiliency—increased significantly at 1- and 6-week FUPs.

Conclusions

The Pathways for Survivors program was favorably received. Anxiety and depression decreased significantly at 1- and 6-weeks after the workshop and remained below baseline at 6 months. Increased HIP-10 scores suggest that patients acquired and implemented skills from the workshop. A 1-day workshop led by a lay moderator significantly improved several psychological measures, suggesting that it may be a useful and time-efficient strategy to improve QOL in breast cancer survivors. We are investigating whether an abbreviated “booster” of the intervention at a later date could further improve and maintain QOL gains.
Gender Biases in Online Physician Ratings: Female Doctors Evaluated More Harshly by Patients (Preprint)
Authors: Barnett Julia , Bjarnadóttir Margrét Vilborg , Anderson David , Chen Chong
Published: December 2021

BACKGROUND

Prior research has highlighted gender differences in online physician reviews, however, to date no research has linked online ratings with quality of care.

OBJECTIVE

To compare a consumer-generated measure of physician quality (online ratings) with a clinical quality outcome (sanctions for malpractice or improper behavior), to understand how patients’ perception and evaluation of doctors differ based on the physician’s gender and quality.

METHODS

We use data from a large online doctor reviews website and the Federation of State Medical Boards. We implement paragraph vector methods to identify words that are specific to and indicative of the separate groups of physicians. We then enrich these findings by utilizing the NRC word-emotion association lexicon to assign emotional scores to the various segments: gender, gender and sanction, and gender and rating.

RESULTS

We find significant differences in the sentiment and emotion of reviews for male and female physicians. We find that numerical ratings are lower and the sentiment in text reviews is more negative for women who will be sanctioned than for men who will be sanctioned; sanctioned male doctors are still associated with positive reviews.

CONCLUSIONS

Conclusions: Given the growing impact of online reviews on demand for physician services, understanding the different reviews faced by male and female physicians is important for consumers and for platform architects in order to revisit their platform design.
RACer-PAP. Investigating the utility and acceptability of a new non-invasive ventilatory assist device, during exercise, in a population of normal, healthy adults: A feasibility study. (Preprint)
Authors: Reeve Julie , Mooney Sarah , Jepsen Nicola , White David
Published: December 2021

BACKGROUND

Non-Invasive Ventilation (NIV) has been demonstrated to benefit people who have moderate to severe COPD during acute exacerbations. Studies have begun to investigate the effectiveness of NIV during pulmonary rehabilitation (PR) to improve outcomes for people with COPD, however the lack of portability and humidification of these devices means the use of such devices is limited, especially when performing activities of daily living. A new prototype device, RACer-PAP, delivers battery-operated positive airway pressure via a nasal interface whilst regulating nasal airway apportionment bias, removing the need for supplementary humidification. This device may offer people with COPD an improved ability to participate in PR and activities of daily living.

OBJECTIVE

To assess the feasibility of exercising with the RACer-PAP in situ and the acceptability of the device during exercise in normal, healthy individuals.

METHODS

15 healthy adults were invited to attend two exercise sessions, one week apart, to assess baseline 6-minute walk distance (6MWD) with and without the RACer-PAP in situ. Vital signs and spirometry were monitored throughout, and spirometry was taken pre and post RACer-PAP testing. Subjective questionnaires ascertained participant feedback on exercising with the device in situ.

RESULTS

14 (93%) participants completed both sessions. There were no adverse events associated with exercising with the device in situ. There were no differences in vital signs and 6MWD whether exercising with or without the device in situ. There were small increases in maximum dyspnoea scores (on Borg scale) on exercise with the device in situ compared with no device on exercise (median/IQR: 2.0/0.5-3.0 vs 3.0/2.0-3.25). There were small increases in forced vital capacity following exercise with the RACer-PAP. None of the participants reported symptoms associated with airway drying. Participant feedback provided recommendations for modifications for the next iteration of the device, prior to piloting the device with people with COPD.

CONCLUSIONS

This study has shown RACer-PAP to be safe and feasible to use during exercise and has provided feedback for modifications to the device to improve its use during exercise. We now propose to consider the application of the device in a small pilot feasibility study to assess safety, feasibility and utility of the device in a population of people with moderate to severe COPD.

CLINICALTRIAL

The study was prospectively registered and approved on ACTRN12619000478112 on 22/03/2019.
Clinicians’ Attitudes Toward Telepsychology in Addiction and Mental Health Services, and Prediction of Postpandemic Telepsychology Uptake: Cross-sectional Study (Preprint)
Authors: Zentner Kristen , Gaine Graham , Ethridge Paige , Surood Shireen , Abba-Aji Adam
Published: December 2021

BACKGROUND

The COVID-19 pandemic has resulted in unprecedented uptake of telepsychology services; however, clinicians have mixed attitudes toward virtual technologies.

OBJECTIVE

This study (1) explored clinicians’ experiences of and intentions to use video, telephone, and in-person services, and (2) tested the utility of the unified theory of acceptance and use of technology (UTAUT) to predict clinicians’ intentions to offer telepsychology after the COVID-19 pandemic.

METHODS

Clinician satisfaction and therapeutic alliance were compared across in-person, video, and telephone services, while technology attitudes and intention to use after the pandemic were compared across video and telephone services among 118 addiction and mental health clinicians during the COVID-19 pandemic.

RESULTS

Clinicians reported more positive experiences with in-person services than both virtual technologies; further, clinicians reported greater positive experiences, attitudes, and intentions to use video services than telephone services across measures. Based on the UTAUT, performance expectancy positively predicted concurrent intentions to use video services (β=0.46; P<.001) and telephone services (β=0.35; P<.001) after the pandemic. Social influence (β=0.24; P=.004) and facilitating conditions (β=0.19; P=.03) additionally predicted the intention to use telephone services.

CONCLUSIONS

Clinicians rated in-person services more positively than virtual technologies, with video services perceived more positively than telephone services. Performance expectancy was the primary facilitator of the uptake of both virtual modalities.
ИСПОЛЬЗОВАНИЕ КЕРАМИКИ ПРОИЗВОДСТВА АО «ЗПП» В МЕТАЛЛОКЕРАМИЧЕСКИХ КОРПУСАХ, РАБОТАЮЩИХ В СВЧ-ДИАПАЗОНЕ
Authors: Ермолаев Е. , Шугаепов Ш. , Ахметгалиев Р.
Published: December 2021

Представлены результаты исследований диэлектрических свойств керамических подложек производства АО «Завод полупроводниковых приборов». Отмечена возможность применения данной керамики для создания совершенно новых, перспективных металлокерамических корпусов, рассчитанных для работы в СВЧ-диапазоне до 40 ГГц включительно.
НОВОЕ ПОКОЛЕНИЕ РЕШЕНИЙ ДЛЯ КОРПУСИРОВАНИЯ ИНТЕГРАЛЬНЫХ СХЕМ. Часть 2
Authors: Фелтон К. , Вертянов Д. , Евстафьев С. , Сидоренко В.
Published: December 2021

Рассматриваются вопросы сквозной интеграции средств проектирования современных корпусов микросхем и микросборок по технологии цифрового двойника: комплексное проектирование составных частей изделия с учетом тепловых характеристик, термомеханических напряжений и целостности сигналов.
Transformar para resistir: resiliencia de redes alimentarias alternativas ante la emergencia de COVID-19 en la Ciudad de México
Authors: Bracamontes Nájera Luis , Benítez Keinrad Mariana
Published: December 2021

La pandemia por covid-19 vino a agudizar los problemas sociales, ambientales y económicos que, desde antes de la emergencia, ya presentaba el sistema agroalimentario hegemónico. Históricamente creadas para ofrecer soluciones a los problemas de este sistema, las redes alimentarias alternativas también han resentido los efectos de la emergencia sanitaria. A partir de revisión bibliográfica y entrevistas a profundidad, este trabajo documenta las respuestas, desafíos y aprendizajes que productoras, consumidoras y coordinadoras de cinco redes de la Ciudad de México tuvieron durante el proceso de adaptación a las nuevas condiciones, así como el papel que los elementos característicos de estas organizaciones tuvieron en su resiliencia frente a los cambios generados por la pandemia. Dentro de los resultados del trabajo, resaltó la importancia que, para la resiliencia de estas organizaciones, tuvieron las relaciones de solidaridad, confianza y reciprocidad establecidas entre sus participantes y con otras redes, así como la utilización de medios de comunicación a distancia y software que permitió el desarrollo de nuevos mecanismos de distribución. La falta de espacios operativos propios, equipos de almacenamiento y recursos de gestión estables y suficientes, así como cierta centralidad en su estructura fueron elementos que implicaron mayor vulnerabilidad.
Food Craving in Obese Subjects: Its Correlation with Atherogenic Index and Feeding Behavior-Related Gene Expression
Authors: Pérez-Vielma Nadia Mabel , Miliar-García Ángel , Gómez-López Modesto , Marín-Soto María Delfina , Leija-Alva Gerardo , Aguilera-Sosa Víctor Ricardo
Published: December 2021

Obesity is influenced by environmental, behavioral, and genetic factors; particularly genes related to the regulation of lipids and addictive behavior. Food craving (FC) is a physiological and behavioral response that triggers the intense desire to ingest food, particularly food with high energy, fat, and/or sweet content. Objective: To evaluate the relationship between the prevalence of FC in obese subjects and blood lipids as well as to determine the transcriptional modulation of CART, DRD2, and FTO. Method: Transverse, comparative, and randomized study including 21 obese participants (BMI, ≥30 kg/m2] and 20 normal weight participants (BMI, ≤25 kg/m2). We determined CART, DRD2, and FTO expressions; evaluated blood lipid levels; and obtained trait scores on the Food Craving Questionnaire-Trait, a multifactorial instrument validated for the Mexican population. Results: The DRD2 expression was significantly increased (p = 0.027) and the CART expression was significantly decreased (p = 0.001) in obese participants compared with normal weight participants. The FTO expression did not show significant differences. Food Craving Questionnaire-Trait showed scores of ≥72 in obese participants. Conclusions: Linear regression model analysis showed that FC is a predictor of atherogenic index (ATH), independently of BMI, and of the gene expression modulation of CART and DRD2.
Delay Factor Analysis for Indian HAM Highway Construction Projects
Authors: Rathore Avinash
Published: December 2021

Abstract: Government has approved the hybrid annuity model (HAM) for building National Highways (NH) to speed up the construction of roads in the country by renewing interest of private developers in highway projects. 40% the Project Cost is to be provided by the Government as Construction Support during the construction period and the balance 60% as annuity payments over the operations period along with interest thereon to the concessionaire. Execution of hybrid annuity model (HAM) projects, which is the preferred mode of awarding by the National Highways Authority of India (NHAI), is largely on schedule with about 60% of projects, covering 3,200 km of roads, completed on time. The rest of the projects, however, are delayed largely due to various reasons. In order to identify and analysis of delay causes in highway projects of HAM model, this study provides a questionnaire survey-based study. Land acquisition delay is found as the most severe delay cause of highway projects of HAM model. Waste of time in controlling the traffic is found as the least severe delay cause of highway projects of HAM model. The study is supposed as useful to HAM construction managers for delay analysis of highway projects. Keywords: Hybrid annuity model, Highway projects, Delay analysis, Questionnaire survey.
La lucha urbana por la reconquista y la redefinición del espacio público en América Latina
Authors: Retamal-Quijada Florencia , Pavez-Estrada Javiera
Published: December 2021

Since its inception in ancient Greece, public space has played a key role in the politics and democracy of cities. Its role has been degraded in post-modernity, and reached its deepest crisis in the full maturity of the post-Fordist system (from 1990 onwards). This economic and representation depression, as well as institutional legitimacy, that States are experiencing, have promoted the emergence and resurgence of different social movements that flood cities globally. Here is where the concern of the Frente Urbano Amparo Poch y Gascón collective lies, formed by the authors, to recognize and characterize, from a socio-urban logic, these manifestations and the sustained occupation that public spaces have experienced in different Latin American cities during the last decade. This research, framed within the Virtual Latin American Meeting, Utopías Líquidas, is proposed starting from a mixed methodology of collective mapping, recognizing public spaces, and characterizing their occupation exercised by Latin American social movements, in the dispute to redefine them and regain their political character, and thus value the different Latin American social movements and their struggles, in an act that encourages resistance and solidarity.
Ultrasound examination of myometrial changes after conservative myomectomy, with the aim of predicting the course of pregnancy and choosing the optimal method of delivery
Authors: Kupatadze D. D. , Safronova M. M.
Published: December 2021

Introduction. The article provides a methodology for assessing and predicting complications during pregnancy for selectionof the optimal method of delivery.Goals and objectives. The work assessed the degree of myometrium changes, according to ultrasound studies, after using standard instrumentation and electrocoagulation, in order to predict the course of pregnancy and select the optimal method of delivery.Materials and methods. The details of the surgical anatomy, the plan of the surgeon’s action before the operation, formed according to the data of ultrasound diagnostics and operative surgery, were analyzed. Ultrasound was performed using GE Logiq S8 (USA) and Medisan Accuvix (South Korea) devices with 3,5 MHz convex transducers for transabdominal examination and with a frequency of 5 MHz for transvaginal examination.Research results. Laparoscopic myomectomy was performed in 18 women, 31 patients underwent laparotomic myomectomy, in 11 patients a combined operation technique was used: laparoscopy with minilaparotomy. According to our data, in half of the cases considered, the effects of interventions were absent or minimal. We assigned these results to group I (A — A1, A2, A3). In all other observations, cicatricial changes were revealed — group II (B, C, D, E). To predict the possible consequences, we proposed a point assessment of the ultrasound postoperative changes in the uterus, with the help of which it is possible to assess the degree of risk when planning pregnancy for each patient individually. Each group corresponds to a certain number of points.Conclusions. The presented division according to the degree of severity into groups can make it possible to individualize the approach to each patient and ensure the safest possible management of her during pregnancy and childbirth. This assessment can be used by ultrasound doctors and obstetricians-gynecologists of antenatal clinics and hospitals. The assessment presented by us at the moment is of a recommendatory nature.
El patrimonio arqueológico de Soacha su plan de manejo y protección
Authors: López Anny Catalina , Rodríguez Mario Andrés , Leguizamón Laura Paloma
Published: December 2021

El texto que tiene en sus manos es una importante mirada al pasado. Es el resultado de un trabajo conjunto entre la Alcaldía de Soacha y el Instituto Colombiano de Antropología e Historia (ICANH), liderado por un grupo de arqueólogos en cabeza de Anny Catalina López, que nos permite asomarnos, como a la ventana del pasado, para ver, entender y aprender cómo fue esa historia milenaria que nos antecedió. Esta cartilla, que está dirigida a un público muy amplio, tiene ese propósito: que todos podamos dar una vuelta por un tiempo que, aunque remoto, está lleno de historias. El texto inicia con la legislación vigente que protege el patrimonio arqueológico en nuestro país. Nos presenta una breve síntesis de lo que se sabe de ese pasado gracias a los estudios arqueológicos. También nos cuenta qué es el proyecto Arqueo-Soacha, cuáles fueron los resultados que se obtuvieron y cómo hacer el manejo de esos bienes arqueológicos para protegerlos y divulgarlos de la mejor manera.