bluuebunny/crossref_metadata_2025 huggingface dataset:
Fracture-Dedicated Prosthesis Promotes the Healing Rate of Greater Tuberosity in Reverse Shoulder Arthroplasty: A Meta-Analysis
Authors: He Shu-Kun , Liao Jing-Ping , Guo Jin-Hai , Huang Fu-guo
Published: December 2021

Introduction: Reverse shoulder arthroplasty (RSA) is becoming popular in the treatment of complex proximal humeral fractures (PHFs). Greater tuberosity healing may influence functional outcomes and range of motion (ROM) of shoulder after RSA. In addition, the design of prosthesis may impact the healing rate of greater tuberosity. The purpose of this study is to know: (1) does the healing of greater tuberosity affect the functional outcomes and ROM of shoulder? and (2) does the design of prosthesis affect the healing rate of greater tuberosity?

Materials and Methods: PubMed, Ovid/Embase, and the Cochrane Library were searched for studies comparing the clinical outcomes between the healed groups and the non-healed groups after RSA.

Results: For functional outcomes, the results showed that the healed group had better Constant scores (CSs) (p < 0.0001). For ROM, the healed group showed better flexion (p < 0.0001), abduction (p = 0.02), and external rotation (p < 0.00001) of shoulder. For the design of prosthesis, the mean healing rate of greater tuberosity (82.7%) in patients with fracture-dedicated prosthesis was higher than those (63.0%) in patients with standard prosthesis. Subgroup analyses showed that the CS (p = 0.12) and abduction (p = 0.96) of patients using fracture-dedicated prostheses were not different between the healed groups and the non-healed groups. Meta-regression showed that there was no significant relationship between the design of prosthesis and CS (p = 0.312), flexion (p = 0.422), or external rotation (p = 0.776).

Conclusion: Our meta-analysis showed that the healed groups could obtain better functional outcomes and ROM than the non-healed groups. In addition, fracture-dedicated prostheses promoted the healing rate of greater tuberosity.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020157276, PROSPERO: CRD42020157276.
Effects of Oral Administration of Lepidium meyenii on Morphology of Mice Testis and Motility of Epididymal Sperm Cells After Tetrahydrocannabinol Exposure
Authors: Greco Adelaide , Del Prete Chiara , De Biase Davide , Palumbo Veronica , Albanese Sandra , Bruzzese Dario , Carotenuto Domenico , Ciani Francesca , Tafuri Simona , Meomartino Leonardo , Mancini Marcello , Paciello Orlando , Cocchia Natascia
Published: December 2021

Background: Tetrahydrocannabinol (THC) administration is associated with testicular damage and reduced semen quality. Oral administration of Lepidium Meyenii (maca) improves spermatogenesis and sperm motility and count and reduces spermatogenic damage.

Objectives: The aim of this study was to evaluate the effect of administration of THC, maca, and their combination on testicular tissue and semen parameters.

Materials and Methods: Thirty-six-week-old male mice were classified into control, THC, Maca, and THC + Maca groups. The mice were subjected to Eco Color Doppler ultrasound examination of the testicles before and after treatment. After euthanasia, the epididymis, testes, liver, and kidney were collected for histological examination. For morphometry of the testis, tubular diameters and seminiferous epithelium height were measured. Sperm concentration and sperm motilities were assessed. Differences among the groups were assessed using the Kruskal–Wallis and Dunn's post-hoc test.

Results: In all the groups, there were no significant changes in testicular morphology before and after treatment. Histological assessment of the testes showed no alterations in control, no significant alterations in Maca, mild to moderate alterations in THC, and mild alterations in THC + Maca groups. Histological examination of the other organs showed no significant differences among the groups. Tubular diameter showed significantly increased thickening for THC and THC + Maca compared with that for Maca and control. Moreover, seminiferous epithelium height decreased for THC compared with that in the control, Maca, and THC + Maca groups. No statistically significant reduction in the spermatogenic index was observed for THC compared with that for Maca and THC + Maca. Epididymal cross-sections of the groups showed no significant alterations. Sperm concentration and motility were higher for control and THC + Maca groups than in group THC and Maca.

Conclusion:In vivo maca administration reduced the deleterious effect of THC on testicular parenchyma and semen production.
Comparison of a Deep Learning Algorithm vs. Humans for Vertebral Heart Scale Measurements in Cats and Dogs Shows a High Degree of Agreement Among Readers
Authors: Boissady Emilie , De La Comble Alois , Zhu Xiajuan , Abbott Jonathan , Adrien-Maxence Hespel
Published: December 2021

Heart disease is a leading cause of death among cats and dogs. Vertebral heart scale (VHS) is one tool to quantify radiographic cardiac enlargement and to predict the occurrence of congestive heart failure. The aim of this study was to evaluate the performance of artificial intelligence (AI) performing VHS measurements when compared with two board-certified specialists. Ground truth consisted of the average of constituent VHS measurements performed by board-certified specialists. Thirty canine and 30 feline thoracic lateral radiographs were evaluated by each operator, using two different methods for determination of the cardiac short axis on dogs' radiographs: the original approach published by Buchanan and the modified approach proposed by the EPIC trial authors, and only Buchanan's method for cats' radiographs. Overall, the VHS calculated by the AI, radiologist, and cardiologist had a high degree of agreement in both canine and feline patients (intraclass correlation coefficient (ICC) = 0.998). In canine patients, when comparing methods used to calculate VHS by specialists, there was also a high degree of agreement (ICC = 0.999). When evaluating specifically the results of the AI VHS vs. the two specialists' readings, the agreement was excellent for both canine (ICC = 0.998) and feline radiographs (ICC = 0.998). Performance of AI trained to locate VHS reference points agreed with manual calculation by specialists in both cats and dogs. Such a computer-aided technique might be an important asset for veterinarians in general practice to limit interobserver variability and obtain more comparable VHS reading over time.
Are Wealthier Times Healthier in Cities? Economic Fluctuations and Mortality in Urban Areas of Latin America
Authors: Leveau Carlos Marcelo , Tapia Granados José A. , Dos Santos Maria Izabel , Castillo-Riquelme Marianela , Alazraqui Marcio
Published: December 2021

Objective: To analyze the relationship between economic conditions and mortality in cities of Latin America.

Methods: We analyzed data from 340 urban areas in ten countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Guatemala, Mexico, Panama, Peru, and El Salvador. We used panel models adjusted for space‐invariant and time‐invariant factors to examine whether changes in area gross domestic product (GDP) per capita were associated with changes in mortality.

Results: We find procyclical oscillations in mortality (i.e., higher mortality with higher GDP per capita) for total mortality, female population, populations of 0–9 and 45+ years, mortality due to cardiovascular diseases, malignant neoplasms, diabetes mellitus, respiratory infections and road traffic injuries. Homicides appear countercyclical, with higher levels at lower GDP per capita.

Conclusions: Our results reveal large heterogeneity, but in our sample of cities, for specific population groups and causes of death, mortality oscillates procyclically, increasing when GDP per capita increases. In contrast we find few instances of countercyclical mortality.
Optimization of the Fermentation Conditions for Brewing Yeast Biomass Production Using the Response Surface Methodology and Taguchi Technique
Authors: Bărbulescu Iuliana Diana , Ghica Mihaela Violeta , Begea Mihaela , Albu Kaya Mădălina Georgiana , Teodorescu Răzvan Ionuț , Popa Lăcrămioara , Mărculescu Simona Ioana , Cîrîc Alexandru Ionuț , Dumitrache Corina , Lupuliasa Dumitru , Matei Florentina , Dinu-Pîrvu Cristina-Elena
Published: December 2021

Yeast (including brewing yeast) and yeast-based preparations derived from bioprocesses or agroindustrial byproducts represent valuable feed additives and ingredients for ruminants. The optimization of brewing yeast biotechnological processing through fermentation mediated by the brewing yeast strain Saccharomyces pastorianus ssp. carlsbergensis W34/70 was investigated. The cultivation conditions (temperature, pH, carbon source, and nitrogen source) were selected and designed according to a Taguchi fractional experimental plan, with four factors on three levels, and their influence on the evolution of the bioprocess of obtaining the brewing yeast biomass was evaluated. The dependent variables were the yeast biomass amount in wet form, yeast biomass amount in dried form after lyophilization, dried yeast biomass wettability assayed through the contact angle (CA), protein content (PC), and dry matter content (DS). The effects that the experimental conditions had on the system responses were visualized in tridimensional space using the response surface methodology, and the combination of biotechnological parameters that ensured process quality and robustness was then determined using the Taguchi technique through its performance indicator, i.e., the signal-to-noise ratio. By optimizing the biotechnological parameters, this study provides a valuable contribution in the area of brewing yeast biomass processing, with the aim of producing probiotic yeast for ruminant nutrition.
A Food-Safety Risk Assessment of Mercury, Lead and Cadmium in Fish Recreationally Caught from Three Lakes in Poland
Authors: Chałabis-Mazurek Agnieszka , Rechulicz Jacek , Pyz-Łukasik Renata
Published: December 2021

Heavy metals are introduced into water due to anthropogenic activities and can significantly affect an entire ecosystem. Due to their close integration with the water environment, fish are a sensitive indicator of contamination. In addition, fish is an important element in human diets, therefore, monitoring the concentrations of metallic contaminants in their meat is particularly important for food safety. This study aimed to assess the pollution of water ecosystems with selected toxic heavy metals in lakes Dratów, Czarne Sosnowickie, and Syczyńskie. The concentration of Pb, Cd, and Hg in water, sediment, and freshwater fish muscle tissue was determined, and a food safety assessment was performed. The analysis of water and sediments showed that the sediments were characterised by a significantly higher concentration of heavy metals. Presumably, this ecosystem element plays an important role in the uptake of heavy metal contaminants by fish whose levels were higher in planktonophagous and benthophagous fish species as compared to predatory fish. The food safety assessment showed that amounts of heavy metals in the muscle tissue posed no threat to the health of consumers ingesting that fish species, neither individually (THQ) nor collectively (TTHQ).
Large-Eddy Simulations on the Effects of Two Wind Passage Types between Buildings on the Airflow and Drag Characteristics
Authors: Wang Lu , Liu Jing , Jiang Cunyan , Li Biao , Song Di , Lu Ming , Xuan Yingli
Published: December 2021

Passages between buildings comprise the airflow path through the buildings, and the wind passage is often studied in terms of two buildings located parallel or at a certain angle. From the perspective of urban areas, the wind passage can be considered the series connection of all local wind passages between each row of buildings. Whether the central axis of each local wind passage is collinear or not, the wind passages of the building array can be summarized as distorted and streamlined types. Large-eddy simulations (LESs) are employed to assess the impacts of the above two wind passage types on the airflow and drag characteristics. The mean, unsteady flow fields and the drag distributions are discussed to assess the effects of wind passages types. Span-wise airflow was found in the wake region in the case of distorted wind passages (DWP), whereas the recirculating vortices dominated the wake region for the case of streamlined wind passages (SWP). Span-wise airflow enhanced the mean stream-wise velocity U and span-wise velocity U in the wake region, decreased U in the wind passage region, and increased dispersive stress 〈V˜2〉 and 〈U˜2〉 within the urban canopy and the peak Reynolds stress above the urban canopy. Further, it strengthened the individual drag forces of buildings and the fluctuations of span-wise and stream-wise individual drag forces. The air of DWP penetrated deeper than SWP. These findings provide theory and data support for better design of wind passages between buildings and may serve as a foundation for urban design and planning.
Infestation and Seasonal Fluctuation of Gamasid Mites (Parasitiformes: Gamasida) on Indochinese Forest Rat, Rattus andamanensis (Rodentia: Muridae) in Southern Yunnan of China
Authors: Yin Peng-Wu , Guo Xian-Guo , Jin Dao-Chao , Song Wen-Yu , Zhang Lei , Zhao Cheng-Fu , Fan Rong , Zhang Zhi-Wei , Mao Ke-Yu
Published: December 2021

A 12-month consecutive investigation was made at Jingha village in southern Yunnan of southwest China from April 2016 to March 2017. A total of 2053 Indochinese forest rats (Rattus andamanensis Blyth, 1860) were captured and examined, which account for 84.69% (2053/2424) of all the animal hosts (rodents and other small mammals) at the investigation site. And 39.82% (13,531/33,980) of gamasid mites were identified from the body surface of R. andamanensis and they belong to 41 species, 10 genera, 3 subfamilies and 2 families. Of the 41 species of gamasid mites identified from R. andamanensis, Laelaps nuttalli Hirst, 1915 and Laelaps echidninus Berlese, 1887 were the most dominant with 70.63% and 20.67% of constituent ratios respectively. In monthly fluctuations of all the gamasid mites on R. andamanensis, the constituent ratio (Cr) and overall infestation mean abundance (MA) of the mites in 12 months showed two obvious peaks in January (winter season) and June (summer season). However, the two dominant mite species, L. nuttalli and L. echidninus, showed different patterns of seasonal fluctuations. Laelaps nuttalli occurred throughout the year, and its Cr and MA showed two prominent peaks in winter season (December and January) and summer season (June), which belongs to the summer-winter type of seasonal fluctuation. Laelaps echidninus also occurred on R. andamanensis throughout the year, but its Cr and MA showed only one peak in winter season (December and January), which belongs to the winter type of seasonal fluctuation. A negative correlation existed between two climatic factors (temperature and rainfall) and the infestations (Cr, prevalence PM and MA) of two dominant mite species (L. nuttalli and L. echidninus) on R. andamanensis (p < 0.05). Temperature and rainfall are considered to be two key factors that influence the seasonal fluctuations of the mites on the studied rat species.
Characterization of the Leucocyte Immunoglobulin-like Receptor B4 (Lilrb4) Expression in Microglia
Authors: Kretzschmar Felix , Piecha Robin , Jahn Jannik , Potru Phani Sankar , Spittau Björn
Published: December 2021

As resident innate immune cells of the CNS, microglia play important essential roles during physiological and pathological situations. Recent reports have described the expression of Lilrb4 in disease-associated and aged microglia. Here, we characterized the expression of Lilrb4 in microglia in vitro and in vivo in comparison with bone marrow-derived monocytes and peritoneal macrophages in mice. Using BV2 cells, primary microglia cultures as well as ex vivo isolated microglia and myeloid cells in combination with qPCR and flow cytometry, we were able to provide a comprehensive characterization of Lilrb4 expression in distinct mouse myeloid cells. Whereas microglia in vivo display low expression of Lilrb4, primary microglia cultures present high levels of surface LILRB4. Among the analyzed peripheral myeloid cells, peritoneal macrophages showed the highest expression levels of Lilrb4. Moreover, LPS treatment and inhibition of microglial TGFβ signaling resulted in significant increases of LILRB4 cell surface levels. Taken together, our data indicate that LILRB4 is a reliable surface marker for activated microglia and further demonstrate that microglial TGFβ signaling is involved in the regulation of Lilrb4 expression during LPS-induced microglia activation.
Oligomeric States and Hydrodynamic Properties of Lysyl Oxidase-Like 2
Authors: Meier Alex A. , Moon Hee-Jung , Toth Ronald , Folta-Stogniew Ewa , Kuczera Krzysztof , Middaugh C. Russell , Mure Minae
Published: December 2021

Lysyl oxidase-like 2 (LOXL2) has emerged as a promising therapeutic target against metastatic/invasive tumors and organ and tissue fibrosis. LOXL2 catalyzes the oxidative deamination of lysine and hydroxylysine residues in extracellular matrix (ECM) proteins to promote crosslinking of these proteins, and thereby plays a major role in ECM remodeling. LOXL2 secretes as 100-kDa full-length protein (fl-LOXL2) and then undergoes proteolytic cleavage of the first two scavenger receptor cysteine-rich (SRCR) domains to yield 60-kDa protein (Δ1-2SRCR-LOXL2). This processing does not affect the amine oxidase activity of LOXL2 in vitro. However, the physiological importance of this cleavage still remains elusive. In this study, we focused on characterization of biophysical properties of fl- and Δ1-2SRCR-LOXL2s (e.g., oligomeric states, molecular weights, and hydrodynamic radii in solution) to gain insight into the structural role of the first two SRCR domains. Our study reveals that fl-LOXL2 exists predominantly as monomer but also dimer to the lesser extent when its concentration is <~1 mM. The hydrodynamic radius (Rh) determined by multi-angle light scattering coupled with size exclusion chromatography (SEC-MALS) indicates that fl-LOXL2 is a moderately asymmetric protein. In contrast, Δ1-2SRCR-LOXL2 exists solely as monomer and its Rh is in good agreement with the predicted value. The Rh values calculated from a 3D modeled structure of fl-LOXL2 and the crystal structure of the precursor Δ1-2SRCR-LOXL2 are within a reasonable margin of error of the values determined by SEC-MALS for fl- and Δ1-2SRCR-LOXL2s in mature forms in this study. Based on superimposition of the 3D model and the crystal structure of Δ1-2SRCR-LOXL2 (PDB:5ZE3), we propose a configuration of fl-LOXL2 that explains the difference observed in Rh between fl- and Δ1-2SRCR-LOXL2s in solution.
Window View Access in Architecture: Spatial Visualization and Probability Evaluations Based on Human Vision Fields and Biophilia
Authors: Parsaee Mojtaba , Demers Claude , Potvin André , Hébert Marc , Lalonde Jean-François
Published: December 2021

This paper presents a computational method for spatial visualization and probability evaluations of window view access in architecture based on human eyes’ vision fields and biophilic recommendations. Window view access establishes occupants’ visual connections to outdoors. Window view access has not, yet, been discussed in terms of the typical vision fields and related visual experiences. Occupants’ views of outdoors could change from almost blocked and poor to good, wide, and immersive visions in relation to the binocular focus to monocular (far-) peripheral sights of human eyes. The proposed methodological framework includes spatial visualizations and cumulative distribution functions of window view access based on visual experiences of occupants. The framework is integrated with biophilic recommendations and existing rating systems for view evaluations. As a pilot study, the method is used to evaluate occupants’ view access in a space designed with 15 different configurations of windows and overhangs. Results characterize likelihood of experiencing various field of views (FOVs) in case studies. In particular, window-to-wall-area ratios of between 40% and 70% offer optimum distributions of view access in space by offering 75% likelihoods of experiencing good to wide views and less than 25% probabilities of exposing to poor and almost blocked views. Results show the contribution of the proposed method to informative decision-making processes in architecture.
Biological Synthesis of Nanocatalysts and Their Applications
Authors: Roy Arpita , Elzaki Amin , Tirth Vineet , Kajoak Samih , Osman Hamid , Algahtani Ali , Islam Saiful , Faizo Nahla L. , Khandaker Mayeen Uddin , Islam Mohammad Nazmul , Emran Talha Bin , Bilal Muhammad
Published: December 2021

Over the past few decades, the synthesis and potential applications of nanocatalysts have received great attention from the scientific community. Many well-established methods are extensively utilized for the synthesis of nanocatalysts. However, most conventional physical and chemical methods have some drawbacks, such as the toxicity of precursor materials, the requirement of high-temperature environments, and the high cost of synthesis, which ultimately hinder their fruitful applications in various fields. Bioinspired synthesis is eco-friendly, cost-effective, and requires a low energy/temperature ambient. Various microorganisms such as bacteria, fungi, and algae are used as nano-factories and can provide a novel method for the synthesis of different types of nanocatalysts. The synthesized nanocatalysts can be further utilized in various applications such as the removal of heavy metals, treatment of industrial effluents, fabrication of materials with unique properties, biomedical, and biosensors. This review focuses on the biogenic synthesis of nanocatalysts from various green sources that have been adopted in the past two decades, and their potential applications in different areas. This review is expected to provide a valuable guideline for the biogenic synthesis of nanocatalysts and their concomitant applications in various fields.
Diagnostic Accuracy of Nasopharyngeal Swab Cultures in Children Less Than Five Years with Chronic Wet Cough
Authors: Asseri Ali A. , Khattab Nasim , Ezmigna Dima , Awadalla Nabil J. , Daines Cori , Morgan Wayne
Published: December 2021

Background: It is necessary to find a non-invasive and accurate procedure to predict persistent bacterial bronchitis (PBB) causative organisms and guide antibiotic therapy. The study objective was to compare the diagnostic accuracy of nasopharyngeal swab cultures with bronchoalveolar lavage (BAL) cultures in children with PBB. Methods: Nasopharyngeal swab and BAL fluid specimens were collected and cultured for bacterial pathogens prospectively from less than five-year-old children undergoing flexible bronchoscopy for chronic wet cough. Results: Of the 59 children included in the study, 26 (44.1%) patients had a positive BAL bacterial culture with neutrophilic inflammation. Prevalence of positive cultures for any of the four common respiratory pathogens implicated in PBB (Moraxella catarrhalis, Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenzae) was significantly higher (p = 0.001) in NP swabs compared to BAL fluids (86.4% and 44.1% of PBB cases, respectively). NP swab cultures for any of the four main bacterial pathogens had 85% (95% CI: 65–96%) and 48% (95% CI: 31–66%) sensitivity and specificity of detecting PBB, respectively. Positive and negative predictive values were 56% (95% CI: 47–65%) and 80% (95% CI: 60–91%), respectively. In conclusion, in children less than 5 years of age with chronic wet cough (PBB-clinical), a negative NP swab result reduces the likelihood of lower airway infection; however, a positive NP swab does not accurately predict the presence of lower airway pathogens. Flexible bronchoscopy should be considered in those with recurrent PBB-clinical or with clinical pointers of central airway anomalies.
The Role of Ferrous Ion in the Effect of the Gadolinium-Based Contrast Agents (GBCA) on the Purkinje Cells Arborization: An In Vitro Study
Authors: Kartamihardja Achmad Adhipatria Perayabangsa , Ariyani Winda , Hanaoka Hirofumi , Taketomi-Takahashi Ayako , Koibuchi Noriyuki , Tsushima Yoshito
Published: December 2021

Gadolinium deposition in the brain has been observed in areas rich in iron, such as the dentate nucleus of the cerebellum. We investigated the role of Fe2+ in the effect of gadolinium-based contrast agents (GBCA) on thyroid hormone-mediated Purkinje cell dendritogenesis in a cerebellar primary culture. The study comprises the control group, Fe2+ group, GBCA groups (gadopentetate group or gadobutrol group), and GBCA+Fe2+ groups. Immunocytochemistry was performed with an anti-calbindin-28K (anti-CaBP28k) antibody, and the nucleus was stained with 4′,6-diamidino-2-phenylindole (DAPI). The number of Purkinje cells and their arborization were evaluated with an analysis of variance with a post-hoc test. The number of Purkinje cells was similar to the control groups among all treated groups. There were no significant differences in dendrite arborization between the Fe2+ group and the control groups. The dendrite arborization was augmented in the gadopentetate and the gadobutrol groups when compared to the control group (p < 0.01, respectively). Fe2+ significantly increased the effect of gadopentetate on dendrite arborization (p < 0.01) but did not increase the effect of gadobutrol. These findings suggested that the chelate thermodynamic stability and Fe2+ may play important roles in attenuating the effect of GBCAs on the thyroid hormone-mediated dendritogenesis of Purkinje cells in in vitro settings.
Key Generation Method Based on Multi-Satellite Cooperation and Random Perturbation
Authors: Hao Yinuo , Mu Pengcheng , Wang Huiming , Jin Liang
Published: December 2021

In low-earth-orbit (LEO) satellite-to-ground communication, the size of satellite antennae is limited and the satellite motion trajectory is predictable, which makes the channel state information (CSI) of the satellite-to-ground channel easy to leak and impossible to use to generate a physical layer key. To solve these problems, we propose a key generation method based on multi-satellite cooperation and random perturbation. On the one hand, we use multi-satellite cooperation to form a constellation that services users, in order to increase the equivalent aperture of satellite antennae and reduce the correlation between the legal channel and the wiretap channel. On the other hand, according to the endogenous characteristics of satellite motion, a random perturbation factor is proposed, which reflects the randomness of the actual channel and ensures that the CSI of the legal channel is not leaked due to the predictability of satellite motion trajectory. Simulation results show that the proposed method can effectively reduce the leakage of the legal channel’s CSI, which makes the method of physical layer key generation safe and feasible in the LEO satellite-to-ground communication scene.
Computational Creativity and Aesthetics with Algorithmic Information Theory
Authors: Mondol Tiasa , Brown Daniel G.
Published: December 2021

We build an analysis based on the Algorithmic Information Theory of computational creativity and extend it to revisit computational aesthetics, thereby, improving on the existing efforts of its formulation. We discuss Kolmogorov complexity, models and randomness deficiency (which is a measure of how much a model falls short of capturing the regularities in an artifact) and show that the notions of typicality and novelty of a creative artifact follow naturally from such definitions. Other exciting formalizations of aesthetic measures include logical depth and sophistication with which we can define, respectively, the value and creator’s artistry present in a creative work. We then look at some related research that combines information theory and creativity and analyze them with the algorithmic tools that we develop throughout the paper. Finally, we assemble the ideas and their algorithmic counterparts to complete an algorithmic information theoretic recipe for computational creativity and aesthetics.
The Effects of Fiscal Effort in Tunisia: An Evidence from the ARDL Bound Testing Approach
Authors: Mahfoudh Naoufel , Gmach Imen
Published: December 2021

The purpose of this paper is to examine the various structural determinants of revenue and tax effort in Tunisia. We used on the empirical study an ARDL model to estimate the dynamic equation of fiscal potential and its structural and non-structural determinants covering the period of 1996–2017 in Tunisia. The empirical results show that before 2010, Tunisia fully exploited its fiscal potential, and the tax effort was above unity. After 2010 this trend was reversed. Despite the increase in the tax burden, Tunisia is below potential. The results showed that Tunisia is facing dramatic difficulties in mobilizing more tax revenue with this same taxpayer base. As a result, it is called upon to orient reform actions towards two aspects: broadening the taxpayer base to guarantee more tax fairness and adopting an awareness and motivation strategy aimed at greater tax compliance. Tunisia should adopt reforms that aim to eliminate the flat-rate regime and put in place advantages and procedures to facilitate and motivate the transition from informal to formal. Finally, it would be wise to further regulate cash payments and ensure the application of the legal rules governing the matter. In order to optimize the allocation of budgetary resources and ease the pressure on public finances, it would be appropriate, even with a delay in relation to the legislation to fight tax evasion and fraud by improving the human and material resources made available to the tax administration and consolidating its digitalization efforts.
A Sub-6 GHz MIMO Antenna Array for 5G Wireless Terminals
Authors: Khan Jalal , Ullah Sadiq , Tahir Farooq A. , Tubbal Faisel , Raad Raad
Published: December 2021

This paper presents a novel antenna with its array and MIMO configuration for the 5G sub-6 GHz applications. The proposed antenna element operates at the central frequency of 5.57 GHz dedicated for Sub-6 GHz 5G communication applications. The antenna element holds a circular-shaped radiating portion with an inner-circular slot, plus a rectangular slot at its right edge to make the proposed design resonate at the desired frequency band. The RT5880 substrate is used with a thickness of 0.787 mm, and the low-loss tangent of 0.0009. To achieve a desired gain of 12 dB, a four-element array configuration is adopted, which improved a bore side gain to 12.4 dB from 6.66 dB. Then, the two-port configuration is adopted such that the isolation achieved between them is more than −30 dB. The total efficiency of the proposed antenna array is observed to be more than 80% within the operating bandwidth. Moreover, the Specific Absorption Rate (SAR) analysis is also presented for the proposed MIMO configuration, obeying the standard value (i.e., <2 W/kg for any 10 g of tissue). The measured results are in good agreement with the simulated results. All the simulations of the proposed design are performed in the CST MWS software.
Numerical Simulation on Impacts of Thickness of Nafion Series Membranes and Relative Humidity on PEMFC Operated at 363 K and 373 K
Authors: Nishimura Akira , Toyoda Kyohei , Kojima Yuya , Ito Syogo , Hu Eric
Published: December 2021

The purpose of this study is to understand the impact of the thickness of Nafion membrane, which is a typical polymer electrolyte membrane (PEM) in Polymer Electrolyte Membrane Fuel Cells (PEMFCs), and relative humidity of supply gas on the distributions of H2, O2, H2O concentration and current density on the interface between a Nafion membrane and anode catalyst layer or the interface between a Nafion membrane and cathode catalyst layer. The effect of the initial temperature of the cell (Tini) is also investigated by the numerical simulation using the 3D model by COMSOL Multiphysics. As a result, the current density decreases along with the gas flow through the gas channel irrespective of the Nafion membrane thickness and Tini, which can be explained by the concentration distribution of H2 and O2 consumed by electrochemical reaction. The molar concentration of H2O decreases when the thickness of Nafion membrane increases, irrespective of Tini and the relative humidity of the supply gas. The current density increases with the increase in relative humidity of the supply gas, irrespective of the Nafion membrane thickness and Tini. This study recommends that a thinner Nafion membrane with well-humidified supply gas would promote high power generation at the target temperature of 363 K and 373 K.
Efficient Shading Device as an Important Part of Daylightophil Architecture; a Designerly Framework of High-Performance Architecture for an Office Building in Tehran
Authors: Bazazzadeh Hassan , Świt-Jankowska Barbara , Fazeli Nasim , Nadolny Adam , Safar ali najar Behnaz , Hashemi safaei Seyedeh sara , Mahdavinejad Mohammadjavad
Published: December 2021

(1) Background: considering multiple, and somehow conflicting, design objectives can potentially make achieving a high-performance design a complex task to perform. For instance, shading devices can dramatically affect the building performance in various ways, such as energy consumption and daylight. This paper introduces a novel procedure for designing shading devices as an integral part of daylightophil architecture for office buildings by considering daylight and energy performance as objectives to be optimal. (2) Methods: to address the topic, a three-step research method was used. Firstly, three different window shades (fixed and dynamic) were modeled, one of which was inspired by traditional Iranian structures, as the main options for evaluation. Secondly, each option was evaluated for energy performance and daylight-related variables in critical days throughout the year in terms of climatic conditions and daylight situations (equinoxes and solstices including 20 March, 21 June, 22 September, and 21 December). Finally, to achieve a reliable result, apart from the results of the comparison of three options, all possible options for fixed and dynamic shades were analyzed through a multi-objective optimization to compare fixed and dynamic options and to find the optimal condition for dynamic options at different times of the day. (3) Results: through different stages of analysis, the findings suggest that, firstly, dynamic shading devices are more efficient than fixed shading devices in terms of energy efficiency, occupants’ visual comfort, and efficient use of daylight (roughly 10%). Moreover, through analyzing dynamic shading devices in different seasons and different times of the year, the optimal form of this shading device was determined. The results indicate that considering proper shading devices can have a significant improvement on achieving high-performance architecture in office buildings. This implies good potential for daylightophil architecture, but would require further studies to be confirmed as a principle for designing office buildings.
Solar Power and Energy Storage for Decarbonization of Land Transport in India
Authors: Barton John P. , Thomson Murray
Published: December 2021

By considering the weight penalty of batteries on payload and total vehicle weight, this paper shows that almost all forms of land-based transport may be served by battery electric vehicles (BEV) with acceptable cost and driving range. Only long-distance road freight is unsuitable for battery electrification. The paper models the future Indian electricity grid supplied entirely by low-carbon forms of generation to quantify the additional solar PV power required to supply energy for transport. Hydrogen produced by water electrolysis for use as a fuel for road freight provides an inter-seasonal energy store that accommodates variations in renewable energy supply. The advantages and disadvantages are considered of midday electric vehicle charging vs. overnight charging considering the temporal variations in supply of renewable energy and demand for transport services. There appears to be little to choose between these two options in terms of total system costs. The result is an energy scenario for decarbonized surface transport in India, based on renewable energy, that is possible, realistically achievable, and affordable in a time frame of year 2050.
Numerical Study on Non-Uniform Temperature Distribution and Thermal Performance of Plate Heat Exchanger
Authors: Ham Jeonggyun , Lee Gonghee , Oh Dong-wook , Cho Honghyun
Published: December 2021

In this study, computational fluid dynamics (CFD) analysis was performed to investigate the cause of the thermal stratification in the channel and the temperature non-uniformity of the plate heat exchanger. The flow velocity maldistribution of the channel and the merging parts caused temperature non-uniformity in the channel width direction. The non-uniformity of flow velocity and temperature in the channel is shown in Section 1 > Section 3 > Section 2 from the heat exchanger. The non-uniform temperature distribution in the channel caused channel stratification and non-uniform outlet temperature. Stratification occurred at the channel near the merging due to the flow rate non-uniformity in the channel. In particular, as the mass flow rate increased from 0.03 to 0.12 kg/s and the effectiveness increased from 0.436 to 0.615, the cold-side stratified volume decreased from 4.06 to 3.7 cm3, and the temperature difference between the stratified area and the outlet decreased from 1.21 K to 0.61 K. The increase in mass flow and the decrease in temperature difference between the cold and hot sides alleviated the non-uniformity of the outlet temperature due to the increase in effectiveness. Besides, as the inlet temperature difference between the cold and the hot side increases, the temperature non-uniformity at the outlet port is poor due to the increase in the stratified region at the channel, and the distance to obtain a uniform temperature in the outlet pipe increases as the temperature at the hot side increases.
Addendum: Hackney, A.C.; Willett, H.N. Testosterone Responses to Intensive, Prolonged Endurance Exercise in Women. Endocrines 2020, 1, 119–124
Authors: Hackney Anthony C. , Willett Hannah N.
Published: December 2021

It has been brought to our attention that the Ethics Committee and approval code were missing in the Materials and Methods Section of our published paper [...]
Trichoderma spp. from Pine Bark and Pine Bark Extracts: Potent Biocontrol Agents against Botryosphaeriaceae
Authors: Karličić Vera , Zlatković Milica , Jovičić-Petrović Jelena , Nikolić Milan P. , Orlović Saša , Raičević Vera
Published: December 2021

Pinus sylvestris bark represents a rich source of active compounds with antifungal, antibacterial, and antioxidant properties. The current study aimed to evaluate the antifungal potential of P. sylvestris bark against Botryosphaeria dothidea, Dothiorella sarmentorum, and Neofusicoccum parvum (Botryosphaeriaceae) through its chemical (water extracts) and biological (Trichoderma spp. isolated from the bark) components. The water bark extracts were prepared at two temperatures (80 and 120 °C) and pH regimes (7 and 9). The presence of bark extracts (30%) caused inhibition of mycelial growth of B. dothidea and D. sarmentorum for 39 to 44% and 53 to 60%, respectively. Moreover, we studied the antagonistic effect of three Trichoderma isolates originating from the pine bark. Trichoderma spp. reduced growth of B. dothidea by 67%–85%, D. sarmentorum by 63%–75% and N. parvum by 55%–62%. Microscopic examination confirmed typical mycoparasitism manifestations (coiling, parallel growth, hook-like structures). The isolates produced cellulase, β-glucosidase and N-acetyl-β-glucosaminidase. The volatile blend detected the emission of several volatile compounds with antimicrobial activity, including nonanoic acid, cubenene, cis-α-bergamotene, hexanedioic acid, and verticillol. The present study confirmed in vitro potential of P. sylvestris bark extracts and Trichoderma spp. against the Botryosphaeriaceae. The study is an important step towards the use of environmentally friendly methods of Botryosphaeriaceae disease control.
Long Term Post-Fire Vegetation Dynamics in North-East Mediterranean Ecosystems. The Case of Mount Athos Greece
Authors: Xofis Panteleimon , Buckley Peter G. , Takos Ioannis , Mitchley Jonathan
Published: December 2021

Fire is an ecological and disturbance factor with a significant historical role in shaping the landscape of fire-prone environments. Despite the large amount of literature regarding post-fire vegetation dynamics, the north-east Mediterranean region is rather underrepresented in the literature. Studies that refer to the early post fire years and long term research are rather scarce. The current study is conducted in the socially and geographically isolated peninsula of Mount Athos (Holly Mountain) in northern Greece, and it studies vegetation dynamics over a period of 30 years since the last fire. Field data were collected 11 years since the event and were used to identify the present plant communities in the area, using TWINSPAN, and the factors affecting their distribution using CART. Four Landsat (TM, ETM, OLI) images are employed for the calculation of NDVI, which was found effective in detecting the intercommunity variation in the study area, and it is used for long term monitoring. The study includes four communities, from maquis to forest which are common in the Mediterranean region covering a wide altitudinal range. The results suggest that fire affects the various communities in a different way and their recovery differs significantly. While forest communities recover quickly after fire, maintaining their composition and structure, the maquis communities may need several years before reaching the pre-fire characteristics. The dry climatic conditions of the study area are probably the reason for the slow recovery of the most fire prone communities. Given that climate change is expected to make the conditions even drier in the region, studies like this emphasize the need to adopt measures for controlling wildfires and preventing ecosystem degradation.
Linear Non-Modal Growth of Planar Perturbations in a Layered Couette Flow
Authors: Iliakis Emmanouil G. , Bakas Nikolaos A.
Published: December 2021

Layered flows that are commonly observed in stratified turbulence are susceptible to the Taylor–Caulfield Instability. While the modal stability properties of layered shear flows have been examined, the non-modal growth of perturbations has not been investigated. In this work, the tools of Generalized Stability Theory are utilized to study linear transient growth within a finite time interval of two-dimensional perturbations in an inviscid, three-layer constant shear flow under the Boussinesq approximation. It is found that, for low optimization times, small-scale perturbations utilize the Orr mechanism and achieve growth equal to that in the case of an unstratified flow. For larger optimization times, transient growth is much larger compared to growth for an unstratified flow as the Kelvin–Orr waves comprising the continuous spectrum of the dynamical operator and the gravity edge-waves comprising the discrete spectrum interact synergistically. Maximum growth is obtained for perturbations with scales within the region of instability, but significant growth is maintained for modally stable perturbations as well. For perturbations with scales within the unstable region, the unstable normal modes are excited at high amplitude by their bi-orthogonals. For perturbations with modally stable scales, the Orr mechanism is utilized to excite at high amplitude neutral propagating waves resembling the neutral Taylor–Caulfield modes.
Synergetic Inactivation Mechanism of Protocatechuic Acid and High Hydrostatic Pressure against Escherichia coli O157:H7
Authors: Hao Jingyi , Lei Yuqing , Gan Zhilin , Zhao Wanbin , Shi Junyan , Jia Chengli , Sun Aidong
Published: December 2021

With the wide application of high hydrostatic pressure (HHP) technology in the food industry, safety issues regarding food products, resulting in potential food safety hazards, have arisen. To address such problems, this study explored the synergetic bactericidal effects and mechanisms of protocatechuic acid (PCA) and HHP against Escherichia coli O157:H7. At greater than 200 MPa, PCA (1.25 mg/mL for 60 min) plus HHP treatments had significant synergetic bactericidal effects that positively correlated with pressure. After a combined treatment at 500 MPa for 5 min, an approximate 9.0 log CFU/mL colony decline occurred, whereas the individual HHP and PCA treatments caused 4.48 and 1.06 log CFU/mL colony decreases, respectively. Mechanistically, membrane integrity and morphology were damaged, and the permeability increased when E. coli O157: H7 was exposed to the synergetic stress of PCA plus HHP. Inside cells, the synergetic treatment additionally targeted the activities of enzymes such as superoxide dismutase, catalase and ATPase, which were inhibited significantly (p ≤ 0.05) when exposed to high pressure. Moreover, an analysis of circular dichroism spectra indicated that the synergetic treatment caused a change in DNA structure, which was expressed as the redshift of the characteristic absorption peak. Thus, the synergetic treatment of PCA plus HHP may be used as a decontamination method owing to the good bactericidal effects on multiple targets.
Influential Factors for Sustainable Intention to Visit a National Park during COVID-19: The Extended Theory of Planned Behavior with Perception of Risk and Coping Behavior
Authors: Seong Bo-Hyun , Choi Youngseok , Kim Hyojin
Published: December 2021

Despite the danger of the spread of the COVID-19 pandemic, visits to natural tourism destinations such as national parks are continuing, though people are using less congested trails or minimizing personal contact. Given the danger from COVID-19, the purpose of our study was to use an expanded theory of planned behavior to analyze whether tourists intend to continue to visit national parks. Another purpose for our study was to compare an extant research model based on the theory of planned behavior with the extended model we developed. Frequency analysis, confirmatory factor analysis, structural equation modeling, and other statistical techniques, such as correlation analysis, parsimonious fit index, and squared multiple correlations were employed according to the appropriate objectives. Additionally, the number of 351 participants joined the survey. Our study found that perception of risk of COVID-19 negatively affected attitude and perceived behavioral control in both models. Moreover, the perceived behavioral control had a positive effect on coping behavior. Given the analytical results, our study presents not only theoretical implications for understanding the behavior of those who visit national parks, but also practical implications for operation and management of national parks during the COVID-19 pandemic.