bluuebunny/crossref_metadata_2025 huggingface dataset:
Encapsulated Papillary Carcinoma of The Breast: A Case Series
Authors: Wang Zhaorui , Wang Jingjing , Pan Yubo , Pei Jing
Published: June 2021

Introduction: Encapsulated papillary carcinoma (EPC）of the breast is a rare type of breast cancer with excellent prognosis. It is usually considered a variant of ductal carcinoma in situ (DCIS). However, no consensus on EPC treatment and management has been achieved. We provide some data from our clinical centers to help better manage this disease.Methods: We performed a retrospective analysis of patients diagnosed with EPC from March 2015 to December 2019 at The First Affiliated Hospital of Anhui Medical University. Demographic information, tumor details, immunohistochemical markers, clinical data, stage of the disease, treatment modalities, and oncological outcomes were collected.Results: Eleven cases were included in this retrospective study: three cases had pure EPC, six cases had EPC associated with DCIS, and two cases had EPC associated with invasive cancer. Among the patients, two had lymph node metastases. The mean age of female patients at diagnosis was 53.6 years. The one male patient was 48 years old. The mean tumor size was 2.4 cm. Myoepithelial cell layers were completely absent in all cases. Ten patients were estrogen receptor and progesterone receptor positive and human epidermal growth factor receptor-2 negative. Nine patients underwent mastectomy, and two underwent breast-conserving surgery.Conclusion: Adequate local therapy results in excellent prognosis. Radiation therapy should be offered to patients with EPC who undergo breast-conserving surgery. Immunohistochemistry is necessary in diagnosing EPC and excluding other papillary lesions. Excisional biopsy should be performed to achieve comprehensive diagnosis. Sentinel lymph node biopsy is recommended for patients with EPC.
Clinical features of medication overuse headache following overuse of different acute symptomatic medications: A preliminary study
Authors: Oh Sun-Young , Kang Jin-Ju , Park Hong-Kyun , Cho Soo-Jin , Chu Min Kyung
Published: June 2021

Background Medication overuse headache (MOH) is a growing problem worldwide and is defined as daily or near-daily headache in patients with a primary headache disorder who overuse acute medications. There is debate about whether there are differences in the clinical features and risks of MOH induced by different drugs. Here we investigated the clinical characteristics of patients with MOH following overuse of different acute headache drugs such as triptans and other medications.Methods A multicenter cross-sectional observation study, REgistry for Load and Management of MEdicAtion OveruSE Headache (RELEASE), prospectively collected demographic and clinical data from 114 consecutive patients with MOH according to the International Headache Society criteria between May 2020 and January 2021. We calculated the mean duration until onset of MOH from chronic daily headache (MDMOH), mean monthly frequency of severe headache (MMFSH), mean monthly frequency of seeking medical services (MMFMedS), and mean monthly intake frequency (MMIF) as well as headache impact and neuropsychological tests in patients with MOH after overuse of acute headache drugs.Results A total of 105 eligible MOH patients was included in this study. The patients showed overuse of triptans (31/105, 29.5%), ergotamines (8/105, 7.6%), simple or combination analgesics (37/105, 35.2%), opioids (1/105, 0.9%), and combination of two of more drugs (28/105, 26.7%). The MDMOH was significantly longer for the analgesics group (10.6 years) than the ergotamines (4.1 years), triptans (4.3 years), or multiple drugs group (4.8 years) (p = 0.011, Kruskal–Wallis test). The MMFMedS was lower for the analgesics group (0.37 days per month) than the multiple drugs (0.85 days) or triptans (0.58 days) group (p = 0.008, Kruskal–Wallis test). The MMFSH was significantly lower in the triptans group (7.4 days per month) than in the analgesics (14.4 days) or multiple drugs group (13.7 days) (p = 0.005, Kruskal–Wallis test). The MMIF was higher in the multiple drugs group (25 days per month) than the triptans (18.1 days) or analgesics (19.5 days) group (p = 0.007, Kruskal–Wallis test).Conclusion Data from this prospective multicenter study suggest that the clinical characteristics of MOH depend on the type of overused symptomatic headache medications.
The effect of macrophages polarization on the expression of oxytocin signaling system in enteric neurons
Authors: Shi Yao , Li Shuang , Zhang Haojie , Zhu Jianchun , Che Tongtong , Yan Bing , Li Jingxin , Liu Chuanyong
Published: June 2021

Background: The aim of the current study is to investigate the effect of macrophages polarization on the expression of oxytocin (OT) and oxytocin receptor (OTR) in enteric neurons. Methods: In this study, we used a classic colitis model to observe the correlation between macrophages polarization and OT signaling system. In order to further demonstrate the effect of macrophages, we examined the expression of OT signaling system after depletion of macrophages. Results: The data showed that, in vitro, flowing macrophages polarization to M1 type by LPS, the macrophages supernatant inhibited the expression of OT and OTR in cultured enteric neurons through releasing pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α); flowing macrophages polarization to M2 type by IL4, the macrophages supernatant promoted the expression of OT and OTR in cultured enteric neurons through releasing anti-inflammatory cytokine (TGF-β). Furthermore, M1 macrophages decreased the expression of OT signaling system mainly through STAT3/NF-κB pathways in cultured enteric neurons; M2 macrophages increased expression of OT signaling system mainly through activation of Smad2/3 and inhibiting the expression of Peg3 in cultured enteric neurons. In DSS model, we demonstrated that macrophages were polarized to M1 type during the inflammatory phases, the expression of OT and OTR decreased significantly; and macrophages were polarized to M2 type during the recovery phases, the expression of OT and OTR increased significantly. At the same time, we also found that D-mannose increased the expression of OT and OTR through polarization of macrophages to M2 type. Conclusions: This is the first time to prove that the polarization of macrophages differentially regulates the expression of OT and OTR in enteric neurons.
LncRNA GACAT3 promotes esophageal squamous cell carcinoma progression through regulation of miR-149 /FOXM1
Authors: Su Min , Tang Jinming , Zhang Baihua , Yang Desong , Wu Zhining , Wu Jie , Zhou Yong , Liao Qianjin , Wang Hui , Wang Wenxiang , Xiao Yuhang
Published: June 2021

Background

The long noncoding RNA gastric cancer associated transcript 3 (GACAT3) has been demonstrated to be implicated in the carcinogenesis and progression of many malignancies. However, GACAT3’s levels and role in esophageal squamous cell carcinoma (ESCC) has not been elucidated.
Methods

GACAT3 amounts were investigated in ESCC tissues and cell lines by qPCR. Its biological functions were examined by CCK-8 assay, colony formation assay, flow cytometry, wound healing assay, transwell assay, and xenograft model establishment. The relationship between GACAT3 and miR-149 was assessed by dual-luciferase reporter assay.
Results

GACAT3 amounts were elevated in ESCC tissue and cell specimens. Functional studies showed that GACAT3 silencing reduced the proliferation, migration and invasion of cultured ESCC cells, and decreased tumor growth in mice. Furthermore, GACAT could directly interact with miR-149. In addition, colony formation and invasion assays verified that GACAT3 promotes ESCC tumor progression through miR-149. Moreover, GACAT3 acted as a competing endogenous RNA (ceRNA) to modulate FOXM1 expression.
Conclusions

These findings indicate that GACAT3 functions as an oncogene by acting as a ceRNA for miR-149 to modulate FOXM1 expression in ESCC, suggesting that GACAT3 might constitute a therapeutic target in ESCC.
Metal speciation and pollution assessment across a small-scale mining creek system tributary
Authors: Austria Elmer S , Fuentes Ericho Jeanne M. , Lamorena-Lim Rheo Baguio
Published: June 2021

Sediment and water samples along Acupan creek were examined to assess the degree of toxic metal pollution due to anthropogenic wastes from small-scale gold mining activity in the area. Samples were collected from five different locations representing the upstream, midstream and downstream areas of the creek. The total concentration of As, Cd, Cu and Pb in the sediment and aqueous matrix were determined. Chemical speciation of the target metals in the creek system was performed using geochemical software PHREEQC. The metal concentrations in the sediments of midstream and downstream were higher compared to the average shale value (ASV) and toxicological reference values (TRV). Similarly, the total metal concentrations of As and Cu in creek water exceeded the local guidelines set for effluent waters. Speciation results identified HAsO42−, Cd2+, CuOH+ and PbOH+ as the major species of the target metals. Metal supersaturation in sediment and low solubility in the aqueous matrix point out to re-suspension and transport of metals as colloidal suspensions. The enrichment factor and geo-accumulation index values indicate significant levels of enrichment and pollution in the midstream and downstream area. The pollution load index confirmed the progressive deterioration of the sediment quality along the creek. Speciation and environmental index results confirmed that anthropogenic sources in the midstream were transported to the downstream catchment.
LncRNA MIAT as a Stemness-Associated Transcript Regulates the Proliferation, Migration and Metastasis of Glioma
Authors: Amirmahani Farzane , Asadi Malek Hossein , Vallian Sadeq
Published: June 2021

Purpose: Glioma is the most prevalent category of brain tumors with cancer stem cells. Myocardial infarction-associated transcript (MIAT) is a long non-coding RNA (lncRNA), with altered expression in different diseases and cancers. The purpose of this study was to evaluate the functional role of lncRNA MIAT in glioma.Methods: In this study, lncRNA MIAT expression was evaluated in the TCGA database in common cancers and glioma specimens. The expression of lncRNA MIAT was knocked down by the RNA interference method, and its effects on the characteristics of two glioma cancer cell lines, A172 and U-87MG, were investigated. Results: The findings of the bioinformatics analysis showed an increase in the expression level of lncRNA MIAT in 12 common cancers. The expression of lncRNA MIAT was much greater in glioma tumor tissues compared to other ones. Knocking-down of lncRNA MIAT led to the reduction of proliferation of glioma cancer cells followed by cell cycle arrest at G1 phase. Furthermore, the inhibition of expression of lncRNA MIAT significantly induced apoptosis, senescence and autophagy, but limited the migration ability and Epithelial-Mesenchymal-Transition (EMT) of cancer cells. Moreover, knocking-down of lncRNA MIAT reduced the expression of stemness factors including Oct4, Sox2, and Nanog. This resulted in the upregulation of their downstream miRNAs (micro RNAs), let-7a-5p and miR-29b-3p. Conclusion: Altogether, our findings showed that lncRNA MIAT could control proliferation, migration and metastasis of glioma cells by regulating the Nanog/ Sox2 / MAP1LC3B2/ let-7a-5p / miR-29b-3p axis. These observations proposed that lncRNA MIAT could be considered as a new oncogene in glioma.
Efficacy and Safety of Modified Qing-Ying Decoction for Atopic Dermatitis in Children: Study Protocol for a Randomized Controlled Trial
Authors: LAI Mei Kwan , SUM Chi Him , KAM Connie YC , SONG Tianhe , CHEONG Pui Kuan , CHAN Kam Leung , LOO Steven KF , HON Ellis KL , ZHANG Hongwei , LO Louis CW , CHING Jessica YL , LIN Zhi-Xiu
Published: June 2021

BackgroundAtopic Dermatitis (AD), also known as atopic eczema, is a chronic skin disease characterized by recurring episodes of itchiness with skin erythema and surface damages, such as dry skin, skin thickening and swelling. Long-term treatment with conventional medicine for subacute and moderate atopic eczema is not satisfactory. Evidence from randomized clinical trials suggests the effectiveness of Chinese medicine for the treatmement of AD. The purpose of this study is to explore the efficacy and safety of the modified Qing-Ying Decoction (mQYD) for the treatment of subacute and chronic AD in children through examining the clinical symptoms, quality of life, gut microbiome, and Chinese medicine (CM) body constitution.Methods/designThis is a parallel, randomized, placebo-controlled, double-blind clinical trial with a 12-week treatment and a 4-week follow-up period. A total of 64 participants will be randomly allocated to the treatment group receiving oral mQYD granules or the placebo control group receiving oral placebo granules. Eczema Area and Severity Index (EASI) score will be the primary outcome. Secondary outcome measures include change in symptoms using the Patient-Oriented Eczema Measure (POEM), the Children’s Dermatology Life Quality Index (CDLQI), and the use of concomitant medicines as well as the change in the gut microbiome and CM body constitution types after the 12-week treatment of the mQYD and 4-week follow-up compared to placebo control. Safety parameters include report of adverse events and pathology tests during the trial period.DiscussionThis is the first clinical trial of its kind to test the efficacy and gut microbiome of an innovative Chinese herbal formula modified from a famous ancient formula for the treatment of AD. The outcomes of this trial will provide clinical evidence on the effectiveness and safety of mQYD for the treatment of AD.Trial registrationClinicalTrials.gov, ID: NCT04419584. Registered on 28 July 2020.
A Luteinizing Hormone-based Protocol Versus Traditional Flexible Gonadotropin-Releasing Hormone Antagonist Protocol in Women with Normal Ovarian Response: Study Protocol for a non-Inferiority Trial
Authors: Lv Ya-su , Li Yuan , Liu Shan
Published: June 2021

BackgroundUse of gonadotropin-releasing hormone (GnRH) antagonists during the late follicular phase can prevent premature luteinizing hormone (LH) surge. Many patients demonstrate an insufficient endogenous LH concentration during ovarian stimulation. Previous studies have demonstrated that ultra-low LH concentration influences pregnancy outcomes. However, affected patients cannot be distinguished prior to ovarian stimulation using baseline characteristics alone. With traditional fixed or flexible GnRH antagonist protocols, antagonist administration may further reduce LH activity. Previously, we proved that LH can be used as an indicator for the timing and dosage of antagonist. Patients with a persistently low LH concentration during ovarian stimulation may not require antagonists, whereas antagonist administration can affect reproductive outcomes. To further explore this hypothesis, we designed a randomized clinical trial to compare the LH-based flexible GnRH antagonist protocol with traditional flexible GnRH antagonist protocol in women with normal ovarian response. MethodsThis study was a multicenter, parallel, prospective, randomized, non-inferiority study. The primary efficacy endpoint was cumulative ongoing pregnancy rate per cycle. The study aimed to prove the non-inferiority of cumulative ongoing pregnancy rate per cycle with a LH-based flexible GnRH antagonist protocol versus traditional flexible GnRH antagonist protocol. Secondary endpoints were the high-quality embryo rate, clinical pregnancy rate, and cancellation rate. Differences in cost-effectiveness and adverse events were evaluated. The cumulative ongoing pregnancy rate per cycle in women with normal ovarian response was 70%. Considering that a non-inferiority threshold should retain 80% of the clinical effect of a control treatment, a minimal clinical difference of 14% (one-sided: α, 2.5%; β, 20%) and a total of 338 patients were needed. Anticipating a 10% dropout rate, the total number of patients required was 372.DiscussionThis is the first randomized controlled trial to compare the efficacy of a LH-based treatment regimen with a traditional flexible GnRH antagonist protocol during ovarian stimulation. We hypothesized no significant difference in cumulative ongoing pregnancy rate per cycle between the two protocols. Moreover, patients with insufficient endogenous LH during ovarian stimulation may benefit from LH-based GnRH antagonist protocols. The results will provide new information on when to introduce antagonists and the appropriate dosage of antagonist.Trial registration: ClinicalTrials.gov, ChiCTR1800018077. Registered on 29 August, 2018.
Small area estimates of the low work intensity indicator at voivodeship level in Poland
Authors: Wawrowski Łukasz , Beresewicz Maciej
Published: June 2021

The EU Statistics on Income and Living Conditions (EU-SILC) has provided annual estimates of the number of labour market indicators for EU countries since 2003, with an almost exclusive focus on national rates. However, it is impossible to obtain reliable direct estimates of labour market statistics at low levels based on the EU-SILC survey. In such cases, model-based small area estimation can be used. In this paper, the low work intensity indicator for the spatial domains in Poland between 2005-2012 was estimated. The Rao and You (1994), Fay and Diallo (2012), and Marhuenda, Molina and Morales (2013) models were applied. The bootstrap MSE for the discussed methods was proposed. The results indicate that these models provide more reliable estimates than direct estimation.
A dynamic MST-deltaCoVaR model of systemic risk in the European insurance sector
Authors: Denkowska Anna , Wanat Stanisław
Published: June 2021

This work is a response to the EIOPA paper entitled ‘Systemic risk and macroprudential policy in insurance’, which asserts that in order to evaluate the potential systemic risk (SR), the build-up of risk, especially risk arising over time, should be taken into account, as well as the interlinkages occurring in the financial sector and the whole economy. The topological indices of minimum spanning trees (MST) and the deltaCoVaR measure are the main tools used to analyse the systemic risk dynamics in the European insurance sector in the years 2005-2019. The article analyses the contribution of each of the 28 largest European insurance companies, including those appearing on the G-SIIs list, to systemic risk. Moreover, the paper aims to determine whether the most important contribution to systemic risk is made by companies with the highest betweenness centrality or the highest degree in the obtained MST.
THE ROLE OF ATTITUDES TOWARDS SALES IN PREDICTING SALES PERFORMANCE
Authors: Lučić Lana , Gojčeta Alen
Published: June 2021

Previous research has identified numerous employee’s individual differences that play a role in predicting success in sales work tasks. However, it seems that the role of attitudes towards sales and its relatedness to sales performance has not yet been in-vestigated, which was the aim of this study. This research was conducted on a sample of contact center agents who sell on a daily basis. We collected data on their demo-graphics, personality traits and attitudes towards sales. The information on agents’ objective monthly offer rate and sales performance across six months was provided by the employer. A series of hierarchical linear models showed that men sell more compa-red to women; that success in sales decreases over years of employment; that attitudes predict sales performance and that they are a better predictor then personality traits; and that offer rate does not mediate the relation of attitudes and closed sales. Further-more, the relation between attitudes and sales was not moderated by employee’s gen-der, level of education nor employment duration. These findings are interpreted in light of the theory of planned behavior.
RELATIONSHIPS BETWEEN PHYSICAL ACTIVITY LEVELS AND SATISFACTION WITH PHYSICAL APPEARANCE, PERCEIVED HEALTH AND AFFECTIVE WELL-BEING
Authors: Kaliterna-Lipovčan Ljiljana , Prizmić-Larsen Zvjezdana , Brkljačić Tihana , Brajša-Žganec Andreja , Lučić Lana
Published: June 2021

The study examined the relationships between physical activity levels and satis-faction with physical appearance, perceived health and affective well-being. Data were collected from the research project on well-being in Croatia (CRO-WELL project). The sample, N=2751 aged 19-81, consisted of adult Internet users who completed an on-line survey. Participants rated their satisfaction with physical appearance and their health status. Well-being was assessed by The Scale of positive and negative experience and participants reported how much they experienced positive (6 items) and negative feelings (6 items) over the last month. Two physical activities frequency measures included how many days a week participants were engaged in a vigorous physical activity such as fitness and sport, as well as in moderate physical activity such as walking and gardening. Personality traits, socio-demographic characteristics, and objective health measures were reported and controlled in analyses. The results of regression analyses showed that satisfaction with physical appearance was predicted positively by both measures of physical activities. Satisfaction with health was pre-dicted positively only by engagement in a vigorous physical activity. Concerning the affective well-being, both vigorous and moderate physical activities had a predictive role in experiencing positive feelings over the last month. Experiencing more negative feelings over the last month was predicted by less vigorous physical activities, howe- ver, the predictive value was small. The findings of the study highlight the differential role of vigorous and moderate levels of physical activity in a person’s life and help in understanding their relationships with different measures of well-being, perceived physical appearance and health. Key words: physical activity, physical appearance, affective well-being, health
Investigation of DNA damage and protein damage caused by oxidative stress in canine visceral leishmaniasis
Authors: KIRAL FUNDA , SEKKIN SELIM , PASA SERDAR , ERTABAKLAR HATICE , ULUTAS PINAR ALKIM , ASICI GAMZE SEVRI EKREN
Published: June 2021

Leishmaniasis, considered by the World Health Organization as one of the most important zoonotic diseases, causes death when it is not treated in its self-healing skin form. The aim of this study was to investigate DNA damage and oxidative protein damage that occurs in dogs infected with Leishmania infantum. The study group consisted of 25 dogs, including 10 clinically healthy dogs aged 2 to 6 years and 15 dogs infected with Leishmania infantum diagnosed by means of the rk39 dipstick test and the immunofluorescence antibody test (IFAT). The effects of oxidative stress on protein were evaluated in the dogs infected with Leishmania infantum by determining plasma malondialdehyde, protein carbonyl groups, nitrotyrosine, and total antioxidant capacity in blood. DNA damage, on the other hand, was determined by the COMET method. Plasma protein carbonyl content (PCO) and nitrotyrosine (NT) levels, which are considered as indicators of protein damage, were found to be higher in the dogs infected with Leishmania infantum compared to the control group, but the difference in both values was not statistically significant (p > 0.05). Plasma malondialdehyde (MDA), an indicator of lipid peroxidation, was significantly higher in the dogs infected with Leishmania infantum than in the control group. TAC levels, however, were lower in the leishmanial dogs (p < 0.05). According to the results of the COMET assay, lymphocyte cells were damaged in the leishmanial dogs, and both tail intensity (TI) and tail moment (TM) values were higher in those dogs than they were in the control group (p < 0.05, p < 0.01). The parasites caused oxidative stress through protein and DNA damage in the host and decreased the antioxidant capacity concentration that prevents destructive effects.
STUDIES USING HPLC-PDA IN GABAPENTIN N-DERIVATIZATION REACTIONS WITH 9-FLUORENYLMETHYL CHLOROFORMATE (FMOC-CL)
Authors: Hottes Emanoel , Santos Carla , Souza Heloisa , Lima Marco , Castro Rosane
Published: June 2021

FMOC-Cl is a derivatizing agent widely used both in N-protection reactions of a-amino acids as well as in quantification and detection of amino acids and related molecules using HPLC-PDA or fluorescence analysis. In this work we studied the reaction of FMOC-Cl with gabapentin. However, it was observed that the degradation of gabapentin-N-FMOC and FMOC-Cl to FMOC-OH occur simultaneously in presence of the basic reaction medium which is specific for gabapentin derivatization. The degradation reaction is accelerated in temperatures above 45 °C and also by the time of contact of the reactant and product with basic medium. In this study, gabapentin derivatization reactions were shown to be cleaner and more efficient when an FMOC-Cl/gabapentin ratio of 2:1 was used, at 25 °C over a period of 15 minutes.
Elevated tanks effect on transient pressures: case study
Authors: Darweesh Moustafa S.
Published: June 2021

Elevated tanks are an integral part of the water supply networks. This paper highlights the effect of elevated tanks' location and size on the transient pressures resulting from the sudden failure of pumps. A comparison between the impact of elevated tanks and air vessels on the water hammer was also performed. The Bentley HAMMER model was first validated then applied to analyze the unsteady flow within an actual distribution network. The results display that the elevated tanks have a considerable effect on the surge pressures, where they improve the extreme pressures effectively at and around them, but they cannot fully protect the system from the water hammer risks, as there are still relatively large negative pressures at some distant junctions. Besides, as the tank capacity increases, the surge pressures increase slightly. In our case study, the best location of the elevated tank is at the network extremity and then at the pumping stations, since the minimum pressures improve by 67 and 54%, respectively. Although the present case study may differ from other supply systems, the obtained results can provide an indication of the elevated tanks' role in alleviating undesirable water hammer effects.
Preparation of cellulose nanofiltration membranes and their removal of typical pollutants from drinking water
Authors: Weng Rengui , Tian Feng , Huang Xin , Ni Liufang , Xi Beidou
Published: June 2021

Cellulose membranes have the advantages of good hydrophilicity, excellent mechanical properties, and biodegradability. Therefore, they are the first choice to replace petroleum polymer membranes. In this study, cellulose (BC) and chitosan (CS) were used as raw materials, and N-methylmorpholine-N-oxide (NMMO) was used as solvent. A new kind of cellulose nanofiltration membrane (BC-NFM), cellulose/chitosan nanofiltration membrane (BC/CS-NFM), and interfacial polymerized cellulose/chitosan composite nanofiltration membrane (IP-BC/CS-NFM) were successfully prepared by NaOH hydrolysis and chloroacetic acid carboxymethylation modification, piperazine (PIP), and 1,3,5-trimellitic chloride (TMC) interfacial polymerization, respectively. These two methods were used for the preparation of cellulose nanofiltration membranes for the first time.We also studied their structure, separation performance and their capacity to remove typical pollutants. The results showed that obvious holes appeared on the surface of the nanofiltration membrane obtained by alkali hydrolysis and chloroacetic acid carboxymethylation modification, and the cross-section showed a spongelike structure. The surface of the nanofiltration membrane obtained by interfacial polymerization formed a rough and dense separation layer. The rejection rates of the three kinds of nanofiltration membranes were all over 30% for monovalent salt ions, over 60% for divalent salt ions, over 92% for methyl orange, and over 98% for methyl blue. They had good removal effects for typical pollutants in drinking water.
A supervisory fuzzy logic control scheme to improve effluent quality of a wastewater treatment plant
Authors: Saravana Kumar S. , Latha K.
Published: June 2021

The application of control strategies in wastewater treatment plants has increased to improve their performance for treating influent. The fuzzy logic controller plays a vital role in this work and simulation work was carried out in a benchmark simulation model no.1 (BSM1) framework. The attempted work proposes two control schemes with the objectives of improving the effluent quality and minimizing the number of measurements taken from the plant. The design of fuzzy control schemes is based on five inputs and six outputs in order to accomplish the objectives. Experimental results show improvement in the effluent quality and increase in the efficacy of the control system. The proposed design is implemented using MATLAB with the adaptation in 2014a.
Effect of Precursor Concentration and Annealed Substrate Temperature on the Crystal Structure, Electronic and Optical Properties of ZnO thin film
Authors:   Department of Physics Education, Faculty of Teacher Training and Education, University of Sultan Ageng  Tirtayasa, Rama Denny Muchtar Yus ,   Center of Excellence for Food Security (PUI-PT), University of Sultan Ageng Tirtayasa, Firmansyah Teguh ,   Department of Electrical Engineering, Faculty of Engineering, University of Sultan Ageng Tirtayasa, Trenggono Adhitya ,   Department of Metallurgical Engineering, Faculty of Engineering, University of Sultan Ageng Tirtayasa, Wijaya Danu ,   Department of Metallurgical Engineering, Faculty of Engineering, University of Sultan Ageng Tirtayasa, Antarnusa Ganesha ,   Department of Physics Education, Faculty of Teacher Training and Education, University of Sultan Ageng  Tirtayasa, Suherman Andri ,   Department of Physics Education, Faculty of Teacher Training and Education, University of Sultan Ageng  Tirtayasa
Published: June 2021

This study carried out on the effect of precursor concentration and annealed substrate temperature on the crystal structure, electronic and optical properties of ZnO thin film. An aqueous solution of Acid Nitrite was used as precursors and its concentration was varied from 0.1 M to 0.4 M. The ZnO thin film was deposited on the glass substrate by Spray Pyrolysis Deposition and annealed with different temperature from 300 oC to 600 oC. The crystal structure, electronic and optical properties were investigated by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD) and UV-Spectrometer. XRD result showed that all thin films have amorphous hexagonal wurtzite crystalline. Particle sizes ranging from 21.83 to 43.67 nm were calculated through Debye-Scherer Method. It showed that the concentration of the precursor had slightly impact on the particle size. Meanwhile, the increase in particle size with increasing annealed temperature is found to be gradual. The average transparent of all thin film was more than 80%. The bandgap of the ZnO thin films was estimated by Tauc Plot Relation. It showed that the bandgap values were increased with the increasing of precursor concentration due to Burstein-Moss Effect. In addition, the decrease in band gap values was found with increasing annealed temperature. Our results demonstrated that the varying precursor concentration and annealed substrate temperature can enhance the structure, electronic and the optical properties of ZnO thin films.
Pemanfaataan lingkungan berbasis alam sebagai sumber belajar kelas V di SD 1 Trirenggo Bantul
Authors: Anindita Nimas , Sidabutar Monika
Published: June 2021

Penelitian ini bertujuan mengetahui jenis lingkungan berbasis alam yang digunakan sebagai sumber belajar, mendeskripsikan langkah-langkah pemanfaatan lingkungan alam sebagai sumber belajar, dan mengetahui hambatan dan solusi yang digunakan dalam penelitian. Penelitian ini menggunakan pendekatakan deskriptif kualitatif dengan subjek penelitian yang terdiri dari 2 pendidik dan 8 peserta didik kelas VA dan VB, SD 1 Trirenggo Bantul. Metode pengambilan data menggunakan teknik triangulasi: wawancara, observasi, dan studi dokumentasi. Hasil penelitian menunjukkan bahwa dalam proses pembelajaran pada tema 8 dan 9, pendidik menggunakan lingkungan alam fisik atau abiotik saja sebagai sumber belajar yang terdiri atas; air, tanah, pasir, batu kerikil besar dan kecil. Langkah-langkah pemanfaatan lingkungan sebagai sumber belajar adalah perencanaan, pengorganisasian, pelaksanaan, dan penilaian. Hambatan yang terjadi dalam proses pembelajaran adalah peserta didik tidak mengikuti instruksi yang diberikan oleh pendidik saat melakukan pengamatan. Solusi yang dilakukan oleh pendidik yaitu pendidik menegur, menasehati dan mengingatkan peserta didik.
Implementation of cybernetic learning theory on scientific philosophy learning
Authors: Furaida Laily
Published: June 2021

The topic is focused on cybernetic learning theory and its implementation to scientific philoshophy learning. Theoretical approach and scientific learning can be connected each other with the same purposes on learning process. Cybernetic learning theory attent to information processing substance and organize its connection to be come an information system which is creating a new idea or a new invention of science. Due to this, the main purpose of scientific  philosophy learning is a critical thinking process which construct a new idea that is engaging a kognitive aspect.This research is a literature review. Literature review is a research which compare previous research then connected with a topic that be come a main review (Efron Ravid, 2019). The research design is narrative review. Narrative review well known as traditional literature review which is a literature review with an analysis as a whole in order to construct a theory and context of a research main focus (Stratton, 2019).The implementation of cybernetic learning theory are suitable for scientific philosophy learning for the same goal in order to find out and proceed new information. Information processing theory which is include kognitive aspect has an important role of cybernetic approach. Cybernetic learning theory can be applied on every learning method which is connecting kognitive aspect in its process.
Optimasi Biaya dan Waktu Proyek Konstruksi dengan Lembur dan Penambahan Tenaga Kerja
Authors: Fardila Dinda , Adawyah Nuur Robbyatul
Published: June 2021

ABSTRACT                                                                         In the construction of a construction project, there are three main elements: time efficiency, minimal costs, and appropriate quality. This study aims to calculate changes in the cost and time of project implementation with variations in overtime and additional workforce. Data analysis using Microsoft Project 2010 program and Time-Cost Trade-Off method. The results of this study indicate that (1) the optimum time and costs due to overtime are obtained at the project age of 235 working days with a total project cost of IDR 8,438,038,832 with a project time efficiency of 5 days (2.13%) and a project cost efficiency of IDR 3.559,695 (0.042%). (2) The optimum time and cost due to the addition of labor is the best choice with the results obtained at the project age of 226 working days with a total project cost of IDR 8,429,832,759 with a project time efficiency of 14 days (6.19%) and cost-efficiency. project amounting to Rp. 11,779,674 (0.14%). ABSTRAKDalam pelaksanaan pembangunan suatu proyek konstruksi, terdapat tiga unsur utama yaitu waktu yang efisien, biaya minimal dan mutu yang sesuai. Tujuan dari penelitian ini adalah menghitung perubahan biaya dan waktu pelaksanaan proyek dengan variasi lembur dan penambahan tenaga kerja. Analisis data menggunakan program Microsoft Project 2010 dan metode Time Cost Trade Off. Hasil penelitian ini menunjukkan bahwa (1) Waktu dan biaya optimum akibat lembur didapat pada umur proyek 235 hari kerja dengan total biaya proyek sebesar Rp8.438.038.832 dengan efisiensi waktu proyek sebanyak 5 hari (2,13%) dan efisiensi biaya proyek sebesar Rp3.559.695 (0,042%). (2) Waktu dan biaya optimum akibat penambahan tenaga kerja menjadi pilihan terbaik dengan hasil yang didapat pada umur proyek 226 hari kerja dengan total biaya proyek sebesar Rp8.429.832.759 dengan efisiensi waktu proyek sebanyak 14 hari (6,19%) dan efisiensi biaya proyek sebesar Rp11.779.674 (0,14%).
Simulation of automatic fan with LM35 temperature sensor using ATMEGA8535 microcontroller in Proteus application
Authors: Nardo Aljo Leo , Sugianto Weri
Published: June 2021

The human body actually has a temperature and always releases energy at any time, especially body heat. Humans always react when heat occurs either due to temperature or other things. When heat is generated from the temperature of the air, then humans usually prefer a solution to use a fan as a cooler and conditioner to eliminate the feeling of heat that is felt. But the fan that is often used sometimes makes us bother to turn it on or off. So that an automatic fan is made by utilizing a microcontroller-based temperature sensor equipped with a temperature sensor LM35, ATmega8535 and other circuits that are put together then run. The fan can work automatically with the aim that humans are made easier in the process of activating the fan without having to bother and more efficient in energy use because the fan is only needed if the temperature sensor detects the temperature that has been set. From the results of tests conducted on the simulation the system can work very well according to what has been made. The role of sensors, series, is very important in the success of this project.
Designing of english challenge mobile game application as the media of english language learning
Authors: Setyadharma Vito Pratama Putra , Iryanti Emi , Hidayatulloh Indra , Nugraha Novanda Alim Setya
Published: June 2021

English became the first foreign language that came to Indonesia in 1967. The human needs of English can already be seen through lots of official scientific works in English and its intense competitions globally. However, still, many people finds it difficult to learn English, for example, the difficulty in understanding tenses, differences between writing, reading and pronouncing. By relying on the latest features on smartphone, which on the mean time, smartphone is one of many gadgets that is the most practical to use in anywhere and anytime, plus, with gaming contents as the best multimedia entertainer application, learning English will be more interactive and easier to use. In this research, Construct 2 is used as The Developer App and Game Development Life Cycle (GDLC) method of Rido Ramadan and Yani Widyani’s version is used as The Development Method. The game system tested by using black box and by giving out Questionnaire for User Interface Satisfaction to 24 respondents, to test the system’s usability. It resulted 80,83% for the whole of the system,  meaning that the whole system is quiet interesting in the respondents’s view. Then, the screen display gained 80,41%, this means that the screen display is very interesting and did not confuse the respondents. Technology and information game gained 75,41%, this means that the information contained in the game is quiet good, however, further development is needed. The introduction of the game’s system gained 71,63%, means that some of the system’s ability did not run effectively and needed further repairment and development. The last, usability and user interface gained 76,25%, this means that the game is quiet interactive to the respondents.
Simulation of school business process
Authors: Jeylani Usman , Isbah Muhammad Falihul , Yaqin Muhammad Ainul , Diana E Pinkan Veri
Published: June 2021

School is an institution where people learn reading, writing, and learning to have good character. The school has a social interaction system in an organizational relationship. Every institution must have a business process to achieve its vision and mission. The business process has activities carried out to provide services or products. This study analyzes business process systems in schools by designing school business process simulation scenarios and then implementing the design of AnyLogic Software and it can contribute to optimizing the management of business processes within schools, where processes are more structured and systematic. The method used in this study is the Business Process Improvement (BPI) Method to eliminate errors and provide competitive benefits by improving business processes. In applying the BPI method, the results obtained are recommendations for improving school business processes: (1) Adding Buses to schools, (2) Adding School Cooperative Staff to transport goods, and (3) Adding Cashiers in School Cooperatives.
Scheduling design of Jakarta-Cikampek II elevated toll road project (P.186 – P.187)
Authors: Khalim Abdul , Ghifarsyam Harun Usman , Rozy Nikko , Ma’arif Faqih
Published: June 2021

The key to achieving effective and efficient development goals is by increasing the quality of construction management by collecting up-to-date data about the project's resources, mainly about productivity. In this research space, productivity will be discussed, including human resources and their management. The case study is the project of Jakarta-Cikampek II Elevated Toll Road. This project was a developing project to improve the capacity of the existing Jakarta-Cikampek toll road. This elevated structure will be built right in the area (median and side edge) of the existing toll road, making it interesting to discuss how the construction is carried out. Scheduling analysis in this study was carried out at points P.186 to P.187 of the construction project. The analysis includes identifying the productivity index of labor resources and equipment that has a major role in shaping the scheduling concept. The concept will be performed by determining a network diagram that will use the Critical Path Method (CPM) rule. The data used in this analysis are construction drawing, s-curve plan, worker data, weekly job plan, work method, and some interviews with worker and field project manager. These results obtained the large productivity of workers and equipment, and the duration required to complete the construction starting prom point P.186 to P.187 is 248 working days
STUDI EMPIRIS ALAT PERAGA PENERIMA FREKUENSI RADIO GRF-3300
Authors: Susilo Deddy , Murtianta Budihardja , Murtianta Nathanael Adharta Livendra
Published: June 2021

ABSTRACT:In a wireless communication system, the transmitter and receiver are basic components that have a role in the telecommunications system. The receiving system serves to receive an information signal. The basic structure of a radio frequency receiver system, namely: antenna - low pass filter - low noise amplifier (LNA) - mixer - phase lock loop (PLL) - demodulator - audio output. This article describes an empirical study of the GRF-3300 Receiver RF Circuit Training System by presenting the results of system testing which are very easy to understand, including the workings and functions of the receiver system props and the basic modules used in the receiving system, so that it can be used help electrical engineering students, especially telecommunications engineering majors. From the test results, the RF Circuit Training System GRF-3300 receiver training kit produces a Total Harmonic Distortion test value of around 5% when an input signal of 1Vrms is given.ABSTRAK:Pada sistem komunikasi nirkabel, pemancar dan penerima merupakan komponen mendasar yang berperan dalam sistem telekomunikasi. Sistem penerima berfungsi untuk menerima suatu sinyal informasi. Struktur dasar sistem penerima frekuensi radio yaitu: antena – low pass filter – low noise amplifier (LNA) – mixer – phase lock loop (PLL) – demodulator – audio output. Dalam artikel ini menjelaskan tentang studi empiris Receiver RF Circuit Training System GRF-3300 dengan hasil pengujian yang mudah dimengerti, meliputi cara kerja dan fungsi pada alat peraga sistem penerima serta modul-modul struktur dasar yang digunakan dalam sistem penerima, sehingga dapat membantu mahasiwa teknik elektro khususnya jurusan teknik telekomunikasi. Dari hasil pengujian, alat peraga penerima RF Circuit Training System GRF-3300 menghasilkan nilai THD sekitar 5% pada sinyal masukan sebesar 1Vrms.
PENGEMBANGAN ALAT BANTU PENYUSUNAN DAN BIMBINGAN KARYA ILMIAH DENGAN MODEL SKILL TREE
Authors: Ghozali Fanani Arief , Muchlas Muchlas , Asnawi Rustam , Sudarma Rio Tirto , Feriyanto Dwi
Published: June 2021

ABSTRACT:This study aims to: (1) produce a product in the form of an android application as a tool for the preparation of scientific papers using the skill tree model; (2) knowing the results of the software performance that using the skill tree model. This research is development research with a combined method of the waterfall method and Dick and Carey. This study focuses on software functionality so that testing is carried out by software quality control. Research data obtained through observation, interviews, a document study, and questionnaires. The results of this study are: (1) the product is developed by applying the skill tree model in an android application designed using Android Studio; (2) the test results by quality control, seen from the aspects of functionality, reliability, efficiency, maintainability, and portability, obtained a percentage of 76.9% (Very Good) for supervisor and 77.8% (Very Good) for teacher applications.ABSTRAK:Penelitian ini bertujuan untuk: (1) menghasilkan produk berupa aplikasi android sebagai alat bantu penyusunan karya ilmiah dengan model skill tree; (2) mengetahui hasil unjuk kerja software yang menggunakan model skill tree. Penelitian ini merupakan penelitian pengembangan dengan metode gabungan antara metode waterfall dan Dick and Carey. Penelitian ini memberikan fokus pada fungsionalitas perangkat lunak sehingga pengujian dilakukan oleh quality control perangkat lunak. Data penelitian diperoleh melalui observasi, wawancara, studi dokumen, dan angket. Hasil penelitian ini adalah sebagai berikut: (1) produk dikembangkan dengan menerapkan model skill tree dalam aplikasi android yang dirancang menggunakan Android Studio; (2) hasil pengujian oleh quality control dilihat dari aspek functionality, reliability, efficiency, maintainability, dan portability didapat persentase 76,9% (Sangat Baik) untuk pembimbing dan 77,8% (Sangat Baik) untuk aplikasi guru.
A Comparison between the Use of Cisco Packet Tracer and Graphical Network Simulator 3 as Learning Media on Students’ Achievement
Authors: Sari Liska Mey Ika , Hatta Puspanda , Wihidayat Endar Suprih , Xiao FENG
Published: June 2021

Usually in studying the practice of computer networks, it is encountered several obstacles such as (1) limited computer networks design tools, (2) limited learning time to design computer networks and (3) technical difficulties for finding the solutions of errors. To overcome those barriers as proposed in this study, computer network simulators were used. Computer network simulators were expected to help students designing and simulating networks planned to be applied to computer network practices. This study used two simulators to compare its effectiveness in assisting the students to learn computer networks, which were Cisco Packet Tracer and Graphical Network Simulator 3 (GNS3). This study was aimed to determine the difference of the influence of network simulators to (1) learning achievement, and (2) learning achievement improvement. The quasi-experiment method was used and data were collected through conducting testing before and after the utilization of the simulators. Based on the testing results it was concluded that (1) different effect of using Cisco Packet Tracer and GNS3, the average grade achievement in the class using GNS3 and using Cisco packet tracer were 76.67 and 70 respectively, and (2) improved learning achievement using GNS3 for around 35%, higher than using Cisco Packet Tracer.