bluuebunny/crossref_metadata_2025 huggingface dataset:
Alencar, Thais Estrella de, Democracia, bolsonarismo e a percepção do eleitorado. 2022. 104 f. Dissertação (Mestrado em Ciência Política), Rio de Janeiro, Universidade Federal do Estado do Rio de Janeiro, 2022.
Authors: Soares da Costa Wellington
Published: November 2023

O estudo alude à percepção do eleitorado quanto à democracia no Brasil a partir de quatro dimensões: “apoio aos princípios fundamentais do regime; apoio às instituições do regime; avaliação do desempenho do regime; e apoio aos atores políticos” (p. 5).
El consentimiento informado y la tutela de la autodeterminación del paciente en el derecho civil brasileño
Authors: Porfírio de Sá Lima Éfren Paulo
Published: November 2023

El estudio tiene como objetivo demostrar que la autodeterminación del paciente está en el centro del consentimiento informado. A través del método de investigación documental, de carácter cualitativo, se parte de tres premisas básicas: (i) la relación género-especie, situando el consentimiento informado como una especie del género acto médico; (ii) la distinción entre información clínica e información terapéutica favorece la comprensión de que el acto médico puede descomponerse en el consentimiento informado y la prestación de cuidados de salud; (iii) el consentimiento informado se encuentra en el acto médico, independientemente de la naturaleza contractual o extracontractual del vínculo. A continuación, se analiza el programa obligacional, destacando la prestación positiva de información y la negativa de abstenerse. Desde la perspectiva de que es una obligación compleja, se destaca que ambas están al servicio de la autodeterminación del paciente. Por último, se discute la naturaleza del asentimiento del paciente.
Aplicación de la Jurisprudencia que establece la Improcedencia del Juicio de Amparo en contra del nombramiento del cargo de Rector en las Universidades Públicas Autónomas
Authors: Vázquez Acuña Félix
Published: November 2023

En este estudio se analizan las cinco ejecutorias con las que se estableció la jurisprudencia que nos lleva a afirmar que su correcto alcance debe ser el de considerar improcedente el juicio de amparo contra el nombramiento del cargo de Rector, cuando la ley de creación de la universidad contemple la facultad de un órgano interno para efectuar dicha designación y, por tanto, no se deberá establecer la causal de improcedencia si la facultad no sólo no se contempla, sino que se  prevea al voto libre, secreto y directo de la comunidad universitaria como fuente para la elección de la referida autoridad.
Analysis of the Effect of Population on the Amount of Waste in Jakarta
Authors: Nurrobi Muhammad Anugerah
Published: November 2023

The waste problem in DKI Jakarta is getting worse. According to data from the DKI Jakarta Central Statistics Agency, the amount of waste increased from 2017 to 2021. The capacity of the Final Disposal Site (TPA) has exceeded the limit. Every day community activities grow and develop, but the waste problem cannot be controlled. With these problems, the authors make a hypothesis and correlate whether there is a relationship between the population and the amount of waste, and analyze the waste management facilities provided by the government with a significance level (⍺) of 0.05.
Social Media and Stunting Prevention Campaigns
Authors: Handayani Bekti , Arianto Bambang
Published: November 2023

This research aims to elaborate on the useful role of social media as a campaign channel in preventing stunting in Indonesia. The digital era means that various daily activities of citizens are greatly influenced by social media. The benefits of social media are then used by mothers of toddlers as a channel for information, interaction, participation, decentralization, transparency and digital accountability. Social media can then be used to disseminate various information about nutrition and prevention so that it can then become educational for the public. As a result, information generated by social media has created dynamic and participatory interaction patterns. This is due to the flexibility of the features possessed by various social media platforms, especially for use as the main channel for civic information. This research uses an explanatory qualitative approach with in-depth interview techniques and observations of mothers of toddlers in the Serang Regency area, Banten Province. The research results found that social media has played a role as the main information channel in strengthening knowledge about local food and nutrition for toddlers. This research also found that social media is very effective for use as a promotional channel and stunting prevention campaign.
Advancements in Energy-Harvesting Techniques for Agricultural Applications: A Review
Authors: Pandey Yogesh
Published: November 2023

Abstract: Over time, there has been rapid advancement in wireless sensor network (WSN) technologies. These networks have proven to be efficient tools in enhancing agricultural productivity. One significant development in WSNs is the integration of energy harvesting capabilities, allowing them to extract energy from the surrounding environment and utilize it to power wireless Internet of Things (IoT) devices. Energy harvesting involves converting ambient energy from various sources such as solar power, wind, and mechanical vibrations into usable power for devices. This review focuses on exploring the different techniques of energy harvesting for WSNs that can be effectively employed in agricultural monitoring systems. Additionally, it addresses the power consumption issues prevalent in agriculture and aims to identify the most effective strategies for resolving these problems.
Comprehensive Review and Proposed Model for Multimodal Depression Detection
Authors: Ujalambkar Deepali M.
Published: November 2023

Abstract: Depression has become prevalent in today’s world and is an ever-increasing concern. Amidst the rising cases of depression witnessed every passing year, it has become vital to identify the signs and symptoms leading to it. This paper reviews the advances made in machine learning to detect these signs by exploring four different learning models- text, facial, audio, and EEG. The accuracy of correct identification is analyzed along with the ease of extraction of data, and three modalities are selected for further research based on the aforementioned factors. Furthermore, the paper proposes a hybrid approach that combines the tools and techniques employed in the previous works by integrating the three modalities. A multimodal system is proposed that overcomes the limitations of the unimodal systems explored in the previous papers.
The Impact of Leader in Me on the School Climate and Student Behaviors: A Meta-Analysis
Authors: Villares Elizabeth , Miller A. Eve , Chevalier Jennifer
Published: November 2023

This meta-analysis investigates the impact of the Leader in Me process on teachers’ perceptions of their school climates and student behaviour. Twelve studies involving 198,176 students resulted in an overall effect size of d = .20. The effect sizes for student climate (d = .34) and student behaviour (d = .16) were determined separately. The results of this meta-analysis connect the Leader in Me intervention with the whole-school implementation model for maintaining a supportive learning environment.
Acute kidney injury in rural workers: An environmental-stress nephropathy
Authors: Musso Carlos G. , Aroca-Martínez Gustavo , Avendaño-Echavez Lil , Cadena-Bonfanti Andrés , Castillo Luis , González-Torres Henry , Conde Juan C , Navarro-Quiroz Elkin , Peña-Vargas William , Hernandez Sandra , Velez-Verbel María de los Ángeles , Perez Rafael , Sierra Angélica , Rua Zenen , Palmera Jorge , Terrasa Sergio
Published: November 2023

Introduction: Mesoamerican nephropathy is a tubule-interstitial nephropathy whose etiology is still unknown. However, clinical cases like Mesoamerican nephropathy have been described in other geographically distant and ethnically diverse regions. Still, they all have a common factor: the intensity of heat and rural physical labor.
Objective: To study whether this entity could occur among rural workers in a non-Mesoamerican region with similar climatic and working conditions, in the Colombian Caribbean countryside, and to consider how much repetitive dehydration could weigh in its pathogenesis. 
Methodology: An observational study was carried out, based on field work in a farm in Sitio Nuevo (Colombia) with 28 rural worker volunteers (rice fields), who were measured for weight, blood pressure, and blood and urine samples to measure electrolytes and osmolarity, at 2 times of the day (morning and evening). 
Results: Of the 28 young men workers evaluated, 5 (18%) presented a significant increase in serum creatinine during the day (0.8±0.15 vs 1.2±0.17, p<0.001). The volume of water ingested by the workers was highly variable (2,861 ± 1,591 cc). There was a significant increase in serum sodium (p?0.001), and urinary osmolarity (p=0.01) values between morning and afternoon values in these 5 patients. 
Conclusions: Eighteen percent (18%) of the workers evaluated developed parameters compatible with acute kidney injury and dehydration during the workday in the Colombian Caribbean countryside.
Na subjetivação pelo estado, onde está o sujeito?
Authors: Ferrari Soares Alexandre Sebastião , Da Silva Zanella Alexandre
Published: November 2023

Neste artigo, através de sequências discursivas extraídas de duas matérias publicadas nos portais Extra e G1, veículos de comunicação das Organizações Globo, analisamos, a partir dos pressupostos teóricos-metodológicos da análise de discurso pecheutiana, os efeitos de sentidos produzidos sobre os direitos de travestis e transexuais em condição de cárcere. No discurso jurídico, posto em circulação pelo discurso jornalístico, os lugares possíveis para os sujeitos transexuais/travestis são cristalizados: o fato de serem travestis antecede qualquer sentido que se possa produzir sobre ela/ele; o sexo a/o precede. O biológico prevalece causando um deslizamento do masculino para o feminino produzindo sentido de um entrelugar natural para estes sujeitos. As suas identidades são construídas pelo Estado quase que exclusivamente a partir dos sentidos naturais de criminalidades e prostituição, lugares sempre-já ocupados por esses sujeitos no discurso jornalístico/jurídico.
Interações entre línguas, linguagens, práticas sociais e formas de vida
Authors: Fossali Pierluigi Basso , Mancini Renata
Published: November 2023

Apresentação.
Upaya Meningkatkan Kemampuan Membaca Peserta Didik dengan Metode Gamification di Kelas 2
Authors: Natalia Assa Desi , Noviyanti Silvina , Eka Meilia Giovani
Published: November 2023

Abstrak
Peserta didik sering hanya terdiam, dan tidak merespon setiap pertanyaan dari guru. Pada penelitian ini merupakan suatu Penelitian Tindakan Kelas yang bertujuan untuk mengetahui kemampuan membaca dengan menggunakan metode pembelajaran gamification di kelas 2 SDN 205/IV Jambi. Penelitian ini dilaksanakan dalam dua siklus. Hasil penelitian ini menunjukkan bahwa dengan penerapan metode pembelajaran gamification dalam pembelajaran Bahasa Indonesia pada kelas 2 mampu meningkatkan kemampuan membaca dan pembelajaran efektif. Peningkatan tersebut dapat terlihat pada analisis data setiap siklus. Siklus I sebanyak 66,8%. Pada siklus II sebanyak 89,8% mengalami peningkatan sebanyak 23%. Dan pada penilaian harian yang mereka dapatkan pada siklus I sebanyak 57,7% dan pada siklus II sebanyak 86,1%. Mengalami peningkatan pada penilaian harian yaitu 28,4%. Dari hasil penelitian ini disarankan guru memberikan pemecahan permasalahan yang konkret dialami oleh peserta didik, lalu guru memberi kesempatan kepada peserta didik yang jarang aktif dalam proses pembelajaran untuk menyampaikan hasil pemecahan masalah sehingga akan melatih keberaniannya. Guru hendaknya mengajar dengan santai dan tidak terlalu formal pada saat mengajar dan harus lebih dekat dengan peserta didik pada saat proses pembelajaran dan jangan menggunakan metode ceramah Tujuan dan manfaat dari pembelajaran harus jelas dan tepat sesuai dengan materi yang dipelajari.
Implementasi Instrument Assessment HOTS (Higher Order Thinking Skills) Tema 7 di Kelas 1 Sekolah Dasar
Authors: Magdalena Maria
Published: November 2023

Assessment adalah upaya yang dilakukan untuk mendapatkan data/informasi dari proses dan hasil pembelajaran. Dengan demikian, untuk melakukan penilaian pendidik membutuhkan alat penilaian yang disebut instrumen yang berupa soal-soal untuk menguji kemampuan kognitif, afektif, dan psikomotorik. Tujuan penelitian untuk mendeskripsikan prosedur pengembangan, tingkat validitas, dan tingkat kepraktisan dari produk yang dikembangkan. Model pengembangan yang digunakan adalah ADDIE dengan 5 tahapan yaitu: Analyze, Design, Develop, Implementation and Evaluate. Hasil implementasi yang telah didapatkan dalam penelitian menunjukkan bahwa tingkat validitas materi pada produk sebesar 100% dan berada pada kategori sangat valid, tingkat validitas bahasa pada produk sebesar 92% dan berada pada kategori sangat valid. Tingkat kepraktisan produk yang didapatkan dari respon guru sebesar 87% dan berada pada kategori sangat praktis. Berdasarkan hasil implementasi dari penelitian dapat disimpulkan bahwa instrument assessment HOTS (Higher Order Thinking Skills) secara keseluruhan dapat digunakan dalam pembelajaran.
Penerapan Prinsip Preventive In Action Dalam Menanggulangi Sampah di Kawasan Pasar Kud Kota Tanjungpinang
Authors: Tri Cahyo Purnomo Armando , Puspitaria Gulo Septi , Permatasari Nilam , Irman Irman
Published: November 2023

Pengelolaan sampah merupakan tantangan yang selalu dihadapi oleh setiap daerah, tak terkecuali dengan Kota Tanjungpinang. Sampah yang menumpuk di darat hingga pesisir laut kian meningkat setiap harinya, Dinas Lingkungan Hidup Kota Tanjungpinang mencatat setiap harinya Kota Tanjungpinang memiliki 90-93 Ton sampah rumah tangga dan sejenis sampah rumah tangga, namun angka ini merupakan angka yang diangkut oleh petugas TPST menuju TPA sehingga sampah yang tidak diangkut yang menumpuk di beberapa tempat mungkin angkanya lebih banyak lagi dari apa yang diperkirakan. Amanat pemerintah pusat kepada daerah tentang pengelolaan sampah telah dicantumkan dalam Undang-Undang Nomor 18 Tahun 2008 tentang Pengelolaan sampah. Pemerintah Kota Tanjungpinang sendiripun telah mengatur regulasi pengelolaan sampah didalam Peraturan Daerah Kota Tanjungpinang Nomor 3 Tahun 2015 tentang Pengelolaan Sampah. Tujuan artikel ini adalah meninjau tentang sejauh mana Pemerintah Kota Tanjungpinang dalam mencegah pencemaran lingkungan melalui sampah dengan Prinsip Preventive In Action yang merupakan salah satu prinsip di Hukum Lingkungan. Dengan metode penelitian Yuridis Normatif kepenulisan ini akan meninjau melalui segi peraturan perundang-undangan yang terkait serta pendekatan konseptual melalui Prinsip-Prinsip Hukum yang berlaku.
Enhanced Scheduling to Improve Resident Continuity in a Family Medicine Teaching Clinic
Authors: Carek Stephen M. , Farrow Brittany L. , Nelson Vicki
Published: November 2023

Background and Objectives: Continuity of care is a core concept at the heart of primary care practices. Increased patient-provider continuity of care is associated with better satisfaction scores, better clinical outcomes, decreased hospitalizations and emergency department utilization, improved completion of preventive health services, adherence to medical treatment plans, and improved show rates. Compared to traditional outpatient practices, resident teaching clinics traditionally have lower rates of continuity and face unique challenges in improving continuity given the curricular demands, complex scheduling, and high turnover of providers. The objective of our study was to assess the impact of front office training and new electronic medical record (EMR) scheduling protocols on resident continuity in a family medicine teaching clinic.
Methods: From July 2021 through May 2022, optimized scheduling through a provider search function in the EMR was implemented in a family medicine teaching clinic. We compared the monthly continuity rates between corresponding months in the prior year and the intervention year.
Results: Over an 11-month implementation process, continuity for resident physicians increased from 36.4% to 64.6% (χ2=675.41, P<.001) using EMR tools and scheduling search functions to improve and sustain continuity over the study period.
Conclusions: This intervention to enhance continuity in a family medicine residency clinic led to rapid and sustained improvement in provider continuity. This result demonstrates that optimization of EMR scheduling with tools and protocols can improve overall continuity. This scheduling process can likely be applied to clinical sites for residency programs across disciplines.
O Programa Residência Pedagógica: estudo das dissertações publicadas no Brasil (2018 a 2022)
Authors: Portela Ellen Maria Santos , Hornink Gabriel Gerber
Published: November 2023

A formação de professores é de extrema importância para a melhoria da qualidade educacional no país e, nesse contexto, o Programa de Residência Pedagógica (PRP) emerge como uma iniciativa de destaque. Objetivou-se neste trabalho mapear as produções acadêmicas (dissertações) relacionadas ao PRP, a partir da sua implementação pelo MEC e pela CAPES, no recorte temporal de 2018 a 2022, disponíveis no Catálogo de Teses e Dissertações da CAPES. O PRP, foco deste estudo, tem como um de seus objetivos a imersão do licenciando nas instituições da educação básica, a fim de promover uma incrementação na formação docente e uma relação mais direta das Instituições de Ensino Superior (IES) com as escolas. Utilizando uma abordagem quali-quantitativa, empregou-se descritores específicos para identificar 17 dissertações relevantes, das quais 16 estavam acessíveis e 10 foram efetivamente analisadas (5 não apresentavam relação com a temática). A análise deu-se a partir da leitura flutuante do título, resumo e metodologia das produções identificadas. Procedeu-se com a leitura parcial dos demais tópicos de modo a confirmar sua pertinência ao PRP. A partir das análises dos trabalhos examinados, constatou-se que há uma crescente dos trabalhos envolvendo o PRP, principalmente no que se refere a sua contribuição na formação profissional.
Conversaciones en Twitter sobre educación en tiempos del COVID-19. Sentimientos, temas predominantes y usuarios influyentes
Authors: Guilleumas García Rosa María , Gil Ramírez Hernán
Published: November 2023

La pandemia del COVID-19 obligó a los sistemas educativos mundiales a enfrentar una situación sin precedentes, en la que docentes, estudiantes, procesos académicos y administrativos necesitaron pasar de forma inmediata, generalizada y sin preparación previa a los espacios virtuales. En este escenario, Twitter se convierte en una herramienta fundamental para poder lograr una visión lo más amplia posible de lo sucedido a través de los millones de personas que utilizan este espacio para comunicar sus vivencias, opiniones y sentimientos. Para ello es importante analizar la opinión de las personas que, a través de Twitter, hicieron oír su voz en relación con la educación en los tiempos del COVID-19, con el objeto de identificar los usuarios potencialmente más influyentes, las tendencias en los temas de interés y la polarización de la sociedad en torno a la educación en este particular momento de la historia. En el libro se examina el impacto de la pandemia de COVID-19 en la educación, destacando cómo los cambios que se dieron en la enseñanza durante ese tiempo van a generar transformaciones en el sistema educativo y la sociedad. El análisis de los tuits reveló patrones significativos: La evaluación de sentimientos en los tuits resaltó una prevalencia de mensajes positivos, particularmente en momentos de implementación de medidas sanitarias y discusión sobre la evaluación estudiantil. Los temas más discutidos involucraban la salud, educación virtual y preocupaciones sociales. Los usuarios más influyentes se asociaron mayoritariamente con medios de comunicación. El estudio proporciona una visión detallada de las preocupaciones, los intereses y la dinámica de la influencia en el ámbito educativo durante la pandemia, subrayando la importancia de comprender estos fenómenos para impulsar cambios significativos en la educación.
Inhibition of HCN1 currents by norquetiapine, an active metabolite of the atypical anti-psychotic drug quetiapine
Authors: D'Avanzo Nazzareno , Jacques Amélie Jean
Published: November 2023

Background and Purpose Quetiapine is a second-generation atypical
antipsychotic drug that has been commonly prescribed for the treatment
of schizophrenia, major depressive disorder (depression), and other
psychological disorders. Targeted inhibition of
hyperpolarization-activated cyclic-nucleotide gated (HCN) channels,
which generate Ih, may provide effective resistance against
schizophrenia and depression. We investigated if HCN channels could
contribute to the therapeutic effect of quetiapine, and its major active
metabolite norquetiapine. Experimental Approach Two-electrode voltage
clamp recordings were used to assess the effects of quetiapine and
norquetiapine on currents from wild-type and mutant HCN1 and HCN2
expressed in Xenopus laevis oocytes. Key Results Norquetiapine, but not
quetiapine nor 7-hydroxy quetiapine, has an inhibitory effect on HCN1
channels. Norquetiapine selectively inhibited HCN1 currents by shifting
the voltage-dependence of activation to more hyperpolarized potentials
in a concentration-dependent manner with an IC50 of 13.9 ± 0.8 μM for
HCN1 and slowing channel opening, without changing the kinetics of
closing. Inhibition by norquetiapine primarily occurs from in the closed
state. Norquetiapine inhibition is not sensitive to the external
potassium concentration, and therefore, likely does not block the pore.
Norquetiapine inhibition also does not dependent on the
cyclic-nucleotide binding domain. Norquetiapine had no effect on HCN2
channels. Conclusions and Implications HCN channels are key targets of
norquetiapine, the primary active metabolite of quetiapine. These data
help to explain the therapeutic mechanisms by which quetiapine aids in
the treatment of anxiety, major depressive disorder, bipolar disorder,
and schizophrenia, and may represent a novel structure for future drug
design of HCN inhibitors.
Single cell transcriptomics reveals tumor heterogeneity in myeloid leukemia associated with Down syndrome
Authors: Li Anqiao , Qingqing Yang , Wu Zelin , Chen Peiye , Tan Huo , Huang Zhenqian , Lihua Xu
Published: November 2023

Background: The susceptibility of children with Down syndrome
to acute myeloid leukemia especially acute megakaryocytic leukemia
(AMKL) is much higher than that of general population. The origination
of ML-DS (Myeloid leukemia associated with Down syndrome) cells, the
occurrence, development and tumor heterogeneity of ML-DS are still
[ambiguous](javascript:;). For children with DS, the incidence of
non-AMKL ML-DS is relatively rare, and there is little research on the
pathogenesis of this type of leukemia. Methods: Our study for
the first time using single-cell RNA sequencing (Sc-RNA seq) technology
to analyze the transcriptome of peripheral blood tumor cells from
patients with non-AMKL type ML-DS. Transcriptome analysis of 2202
peripheral blood cells from one patient with non-AMKL ML-DS were
conducted, and the genetic characteristics of leukemia cells were
examined in detail. Results: We reveal that LMO4, CPA3, RAD21,
POU2F2, KIT, and ANXA1 were highly expressed in cluster 0, which
exhibited heightened stem cell characteristics. During the
differentiation of various tumor cell clusters, the expression levels of
CPA3, FCER1A, HPGD, HPGDS, LAPTM5, and LMO4 exhibited significant
difference during the differentiation of different tumor cell clusters.
KEGG pathway enrichment analysis shows that aml-0 subsets are
significantly enriched in microRNAs in cancer pathway, which play a key
role as post transcriptional regulators in leukemogenesis.
Conclusion: Above all, the differential gene expression
characteristics of different tumor cell subpopulations of interest were
analyzed at the single cell level to the heterogeneity of tumor cells
and the different characteristics of subpopulations, and to discover
potential cell stem gene markers.
Analysis of cantharidin-induced kidney injury and the protective mechanism of resveratrol in mice determined by liquid chromatography/mass spectrometry-based metabonomics
Authors: Tang Wenchao , Xiao Yuanyuan , Zhang Xiaoyue , Yang Changfu , Peng Fang
Published: November 2023

Cantharidin (CTD) is the main active component in the traditional
Chinese medicine Mylabris and an effective anti-tumor agent. However, it
is relatively toxic and exhibits nephrotoxicity, which limits its
clinical use. However, its toxic mechanism is not clear. The toxic
effects of CTD exposure on the kidney and the protective effect of
resveratrol were studied in a mouse model, by determination of serum
biochemical and renal antioxidant indicators, histopathological and
ultrastructural observation, and metabonomics. After CTD exposure, serum
uric acid, creatinine, and tissue oxidative stress indicators increased,
and the renal glomerular and tubular epithelial cells showed clear
pathological damage. Ultrastructure observation revealed marked
mitochondrial swelling, endoplasmic reticulum dilation, and the presence
of autophagy lysosomes in glomerular epithelial cells. Resveratrol
ameliorated the renal injury induced by CTD. Metabonomics analysis
indicated that CTD can induce apoptosis and oxidative damage in kidney
cells, mainly by disrupting sphingolipid and glutathione metabolism. RES
counteracts these effects by regulating renal cell proliferation, the
inflammatory response, oxidative stress, and apoptosis, by improving the
glycerophospholipid metabolism pathway, thereby reducing CTD-induced
nephrotoxicity. The mechanisms of CTD-induced nephrotoxicity and the
protective effect of RES were revealed by metabonomics, providing a
basis for evaluating clinical treatment regimens to reduce CTD-induced
nephrotoxicity.
An innovative fixed bed bioreactor platform for linearly scalable, biomass predictable, single-use adherent cell biomanufacturing
Authors: Goral Vasiliy , Hong Yulong , Scibek Jeffery , Sun Yujian , Romeo Lori , Rao Abhijit , Manning Daniel , Zhou Yue , Schultes Joel , Tjong Vinalia , Pikula Dragan , Krebs Kathleen , Ferrie Ann , Kramel Stefan , Weber Jennifer , Melkoumian Zara , Upton Todd , Fang Ye
Published: November 2023

Scalable single use adherent cell-based biomanufacturing platforms are
part of solutions to realize the full potential of cell and gene
therapies. Here, we reported the development of an innovative fixed bed
bioreactor platform for the scale-up of adherent cell culture. The
bioreactor platform is centered on a packed bed of woven polyethylene
terephthalate mesh discs that are vertically stacked and sandwiched
between two fluid guide plates. Computational fluid dynamics modeling
was used to direct the design and development of bioreactor series,
targeting uniform flow with minimal shear stress. Residence time
distribution measurements revealed that a pulse injected dye tracer
solution passed through the bioreactors with great uniformity and narrow
distribution of residence time, mimicking plug flow. Periodic media
sampling with an offline analyzer showed that there was minimal gradient
of four important metabolites (glucose, glutamine, lactate, and ammonia)
across the bioreactor throughout cell growth. The bioreactor platform
was further validated in automated cell harvesting with
~96% efficiency and ~98% viability, as
well as linear scalability, in terms of both operational parameters and
performance, for cell culture and adeno-associated virus vector
production. Finally, mathematic models based on oxygen uptake rates were
developed and proven effective to model cell growth curves and estimate
biomass in real-time. This study shows that this innovative fixed bed
bioreactor platform enables linearly scalable adherent cell-based
biomanufacturing with high productivity.
The long and tortuous path towards improving photosynthesis by engineering elevated mesophyll conductance
Authors: Leverett Alistair , Kromdijk Johannes
Published: November 2023

The growing demand for global food production is likely to be a defining
issue facing humanity over the next 50 years. In order to tackle this
challenge, there is a desire to bioengineer crops with higher
photosynthetic efficiencies, to increase yields. Recently, there has
been a growing interest in engineering leaves with higher mesophyll
conductance (g), which would allow
CO to move more efficiently from the substomatal
cavities to the chloroplast stroma. However, if crop yield gains are to
be realised through this approach, it is essential that the
methodological limitations associated with estimating gm are fully
appreciated. In this review, we summarise these limitations, and outline
the uncertainties and assumptions that can affect the final estimation
of g. Furthermore, we critically assess the
predicted quantitative effect that elevating g
will have on assimilation rates in crop species. We highlight the need
for more theoretical modelling to determine whether altering
g is truly a viable route to improve crop
performance. Finally, we offer suggestions to guide future research on
g, which will help mitigate the uncertainty
inherently associated with estimating this parameter.
Psychological and Technology Factor Contribute to Social Media Addiction
Authors: Mohd Shukur Shamsul Azren , Abu Bakar Syarifah Mastura Syed , Dzulkalnine Natasha , Zaman Maliza Delima Kamarul , Omar Nur Farehan , Sandhu Sukjeet Kaur , Lansam Brenda Anak
Published: November 2023

In the present-day context of worldwide connectivity, social media has emerged as an integral component of many adolescents' everyday routines. However, the seemingly harmless practice of utilizing social networking platforms can swiftly transform into a significant dependency, leading to unfavorable consequences. Adolescents' excessive dependence on social media platforms has garnered significant attention from scholars and practitioners in the mental health field. Psychological and technological elements are recognized as contributing to social media addiction, which has detrimental consequences for adolescents. Hence, the primary objective of this study is to gain a comprehensive understanding of the existing literature about the psychological and technological elements contributing to addiction to social media platforms. The discourse outcomes will illuminate the strategies employed to mitigate social media addiction by addressing the abovementioned factors. This conclusion has significant implications, as it will stimulate further discussion and prompt additional research reviews on the various elements contributing to social media addiction.
Investigating the Causality between Corruption and Economic Growth: A Systematic Review
Authors: Yusof Muhammad Hafizuddin , Mohd Haniff Muhammad Abu Hanifah , Kamaruddin Zulaikha , Mohd Jaafar Nurul Aifa , Saihani Shamsul Baharin
Published: November 2023

This study aims to establish a systematic examination of the existing literature pertaining to the causal relationship between corruption and its impact on a nation economic growth. In line with established methodological guidelines, particularly the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), this research adopts a structured approach to comprehensively survey the relevant scholarly landscape. To construct a robust foundation for this investigation, a thorough search for scientific papers within the Scopus and Web of Science (WoS) databases, spanning the years from 2012 to 2022 was conducted. Our selection process ultimately led to the identification and analysis of seven publications that offer substantial empirical insights into the chosen domain of inquiry. Through a careful review of these research papers, a compelling pattern that corruption exerts a profound significant influence on various dimensions of economic growth within a nation emerged. Specifically, the synthesis of the extant literature suggests that corruption exhibits a discernible causative effect on critical economic parameters, notably including but not limited to purchasing power, country debt, political stability and foreign direct investment (FDI). In summary, the amalgamation of these scrutinized research findings underscores the substantial and multifaceted role of corruption as a causal factor in influencing economic growth dynamics. This investigation not only contributes to a deeper understanding of this critical relationship but also underscores the importance of anti-corruption measures in promoting sustained economic development and stability on a national scale.
Understanding Whistleblowing Intention Among Public Sector Employees in the Northern Region of Malaysia: Does Gender Matter?
Authors: Zairi Zul Muhammad , Syukri Abdullah Muhammad , Normah Awang Tuah Siti , Aqmar Zainudin Zatil , Anidah Aziz
Published: November 2023

The objective of this study is to determine the factors influencing whistleblowing intention among public sector employees. This study utilized the Theory of Prosocial Behavior which includes contextual determinants (policy and procedure, training, responsiveness of management, reporting channel, financial reward, seriousness level of wrongdoing) and individual determinants (knowledge, trust) as independent variables while whistle blowing intention is the dependent variable. Additionally, this study also includes gender as a moderating variable in the relationship between the contextual and individual determinants toward whistleblowing intention. The data was collected from 123 public sector employees in the northern region of Malaysia (Perlis, Kedah, Penang) from various ministries via an online survey questionnaire and analyzed using SmartPLS. This study found that there is a significant relationship between all independent variables and whistleblowing intention, except for the responsiveness of management. Additionally, gender was found to be significant in the relationship between several independent variables and whistleblowing intention.
Analysis of the thermal behavior of a fixed bed reactor during the pyrolysis process
Authors: Djurdjevic Milica , Papuga Sasa , Kolundzija Aleksandra
Published: November 2023

Pyrolysis is a thermochemical process of degradation of organic compounds where the reaction takes place in an inert atmosphere. The process scale varies between industrial, semi-industrial or laboratory. During the pyrolysis process temperature has to be controlled, but, most of pyrolysis studies do not clearly state where the temperature is measured and weather the temperature field is uniform. In this paper thermal behavior of a laboratory scale fixed-bed reactor and energy consumption during pyrolysis processes were analyzed. Three different samples were used: mixture of plastic waste (sample 1), biomass (sample 2) and mixture of plastic waste and biomass (sample 3). The analysis of the thermal behavior of the reactor indicates that with careful regulation or temperature control of the process, one can obtain diagrams that can be used for the purpose of recording thermally intensive processes, similar to more complex thermogravimetric (TG) and derivative thermogravimetric (DTG) analyses. It has been shown that it is possible to change the heating rate and the overall energy efficiency of the process by simply choosing the appropriate raw material mixture.
Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications
Authors: Ugrinovic Vukasin , Markovic Maja , Bozic Bojan , Panic Vesna , Veljovic Djordje
Published: November 2023

Hydrogels are attractive materials for drug delivery applications due to biocompatible, porous structure with the possibility to load and deliver drugs in a controllable manner. In this paper, poly(methacrylic acid) (PMAA) hydrogels are described, which are synthesized by free-radical polymerization, using poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. Influence of the PEGDA content on hydrogel properties was investigated and compared to commonly used crosslinker - N,N?-methylenebisacrylamide (MBA). The increasing concentration of crosslinkers led to a higher degree of crosslinking, which was demonstrated by a higher degree of conversion, lower swelling capacity, and improved thermal stability and mechanical properties. Also, the PEGDA-crosslinked hydrogels demonstrated a higher degree of crosslinking than the corresponding MBA-crosslinked hydrogels. Potential application of the synthesized hydrogels for controlled drug delivery was investigated by using two model drugs - oxaprozin and ciprofloxacin. In vitro drug release tests indicated that the interactions between drug, polymer and medium have a key influence on the drug release behavior, rather than the swelling rate. Drug release tests in simulated gastrointestinal conditions indicated that PEGDA-crosslinked PMAA hydrogels are suitable for colon-targeted delivery of oxaprozin.
Use of a mixture of coal and oil as an additive for selective reduction of lateritic ore by the Caron process
Authors: Angulo-Palma Hugo , Legrá Ángel , Urgellés Alisa , Pedrera Carlos , Gallegos Sandra , Galleguillos Madrid , Toro Norman
Published: November 2023

Lateritic ores constitute the main source of raw material for extraction of Ni and Co by the Caron process. Consumption of oil in the reduction furnace is one of the key indicators if the metallurgical process is economical. To date it has not been possible to replace the additive fuel oil that is used at commercial scales, therefore, the aim of this study was to partially replace the oil with bituminous coal on a pilot scale by using a mixture of 2 % coal and 1.25 % oil as the reducer additive. Phases of the reduced/leached ores were analyzed by powder X-ray diffraction, while the metallic state of the ore was determined by leaching the reacted samples with a bromine-ethanol solution followed by the atomic absorption spectrometry analysis. Extractions of Ni and Co were confirmed by leaching the reduced ore with ammoniacal-ammonium carbonate solutions. It was observed that the mixture used as a reducer additive can replace the fuel oil since it allows the adequate transformation of the main mineralogical phases of the laterite ore during the reduction process and the average extraction yields of Ni and Co for ~3 and ~8 %, respectively. Although the effect of bituminous coal particle size in the process was not analyzed, the reducing mixture ensured that the Caron process was more efficient.
Influence of suspension heating rate on properties of zeolite 13X
Authors: Jankovic Mladen , Perusic Mitar , Damjanovic Vladimir , Filipovic Radislav , Obrenovic Zoran , Tadic Goran , Kostic Dusko
Published: November 2023

It is known that the temperature of crystallization during the synthesis of zeolite is one of the most important process parameters. However, during the research work on the synthesis of zeolite 13X and the introduction of this material into regular industrial production, it was noticed that the heating rate of the starting reaction suspension can have an equally important influence. This influence can be so pronounced that a difference of just a few minutes in reaching the crystallization temperature can make a significant difference in product quality, affect the presence of other phases in the crystal, or even determine the direction of zeolite crystallization. Therefore, the aim of this work was to show the influence of the heating rate on the quality of the obtained 13X zeolite powders. The obtained samples were analysed in terms of crystallinity (by X-ray diffraction), chemical composition, granulometry and specific surface area (by Brunauer-Emmett-Teller analysis), and regarding water and CO2 adsorption capacities. Additionally, scanning electron microscopy analysis of the samples showed the morphological characteristics of different 13X zeolite powders. The analysis results of the obtained powders confirmed the influence of the heating rate and helped to define the optimal synthesis parameters i.e. the initial temperature and heating time, that resulted in stable product quality.
Environmental impact assessment of land consolidation
Authors: Ninkov Jordana , Szabados Klara , Jaksic Snezana , Butorac Branislava , Puzovic Slobodan , Kis Alen , Peric Ranko
Published: November 2023

Land consolidation (LC) is an important tool for the improvement of
agriculture and rural development, which also includes environmental issues
in most of the countries in Europe. This paper presents the most important
results of the environmental impact assessment (EIA) of land consolidation,
conducted in the municipality of Vrsac through a pilot project based on the
EU methodology set within the project: ?Strengthening Municipal Land
Management in Serbia?, supported by the Deutsche Gesellschaft f?r
Internationale Zusammenarbeit (GIZ) GmbH. During the summer of 2018, field
survey was carried out at 90 locations, documenting the natural,
semi-natural and man-made landscape elements of ecological or cultural
values, assessing their quality and estimating the potential harmful
environmental impacts of the land consolidation. The already existing
negative impacts of intensive agriculture were also registered, such as
abandonment or overgrazing of pastures and meadows, converting grasslands
into arable land, soil erosion and habitat fragmentation. Although the area
of LC is without natural forest and extremely poor in semi-natural elements
of rural landscape, the existing entities were revealed as refuges for
protected species. Some of the grassland fragments belonged to protected
habitat types. The final categorization of the landscape elements was
conducted in three levels. Category I landscape elements had to remain
undisturbed; Category II landscape elements could be removed with obligatory
ecological compensation, while the Category III landscape elements could be
removed without environmental compensation. Recommendations were given
pointing out the possibilities for improving the environmental characters of
the area by the land consolidation process.
Implicit or Unconscious Bias in Diabetes Care
Authors: Caballero A. Enrique , ElSayed Nuha A. , Golden Sherita Hill , Bannuru Raveendhara R. , Gregg Brigid
Published: November 2023

“Implicit bias,” also called “unconscious bias,” refers to associations outside of conscious awareness that adversely affect one’s perception of a person or group. Awareness of implicit bias has been increasing in the realm of diabetes care. Here, the authors highlight several types of unconscious bias on the part of clinicians and patients, including biases based on race, ethnicity, and obesity. They discuss how these biases can negatively affect patient-centered clinical interactions and diabetes care delivery, and they recommend implementation of evidence-based interventions and other health system policy approaches to reduce the potential impact of such biases in health care settings.
Accelerometer-measured physical activity at 3 months as a predictor of symptoms of depression and anxiety 1 year after stroke: a multicentre prospective cohort study in central Norway
Authors: Phan Ailan , Askim Torunn , Lydersen Stian , Indredavik Bent , Wethal Torgeir
Published: November 2023

Objectives: To study sedentary behaviour and physical activity at 3 months as predictors for symptoms of depression and anxiety at 1-year post-stroke.
Design: A prospective cohort study.
Patients: Patients with first-ever ischaemic stroke.
Methods: Mood was assessed 3- and 12-months post-stroke using the Hospital Anxiety and Depression Scale. Sedentary behaviour and physical activity were measured using accelerometry 3 months post-stroke.
Results: A total of 292 participants (116 (39.7%) females; mean age 71.7 (standard deviation 11.3) years) were included. At 12 months, 16.7% experienced depression and 19.5% anxiety, respectively. Adjusting for age and sex, regression analysis showed that comorbidity burden (β 0.26; 95% confidence interval (95% CI) 0.02, 0.51; p = 0.038), stroke severity (β 0.22; 95% CI 0.10, 0.35; p = 0.001), functional disability (β 0.89, 95% CI 0.49, 1.30; p = 0.000), and global cognition (β–0.15; 95% CI –0.25, –0.05; p = 0.004) predicted depression. Multi-adjusted analysis showed sedentary behaviour and physical activity did not significantly predict depression or anxiety (p > 0.05).
Conclusion: Sedentary behaviour and physical activity did not significantly predict mood after stroke. Comorbidity burden, stroke severity, functional disability, and global cognition were identified as possible predictors of depression. More research is needed to determine the impact of physical activity on depression and anxiety symptoms.
LA OBRA DE MIGUEL DE UNAMUNO EN EL ESPACIO UCRANIANO: INTERPRETACIÓN Y TRADUCCIÓN
Authors: Mayevska Olga
Published: November 2023

El conocimiento con la obra e ideario del célebre escritor y pensador español del siglo XX, Miguel de Unamuno (1864 – 1936), igual que la traducción de unos de sus textos, empezó ya a finales de los años veinte – treinta del siglo XX y continúa atrayendo a los lectores, críticos y traductores de todo el mundo en la actualidad por desarrollar y analizar los conceptos universales de la existencia humana. En este artículo nos vamos a centrar en los aspectos de la presencia de la obra unamuniana en la cultura y ciencia ucranianas, en particular, en la interpretación y aplicación de sus ideas por los intelectuales ucranianos para determinar el concepto de la nación ucraniana moderna y en la traducción de sus textos al ucraniano en corte diacrónico junto con los desafíos de la traducción. De esa manera demostrando los vínculos entre ambos extremos geográficos de la Europa.
NARRATIVE IN VIDEO GAMES’ VERBAL MODE
Authors: Poliakova Anastasiia , Lut Kateryna
Published: November 2023

As a distinctive form of art, video games feature a narrative element in a similar way that literature, theatre, and cinema do; however, there are certain characteristics that make video game narrative different from its counterparts in other art forms. Through the video games’ brief history (as compared to other art forms), the narrative went from being almost absent and neglected to playing an integral role in the product. The goal of this paper is to research the narrative element present in the verbal mode of video games. Hence, the study focuses on the history and evolution of video games and narratives represented in them. It also considers the peculiarities of video game texts resulting in their analysis and detailed description. Methods used in the research include induction, deduction, synthesis and analysis; categorization; descriptive method, and historical method. Practical importance of the paper lies in that the results may become the basis for further investigation of narrative elements and the role texts play in video games.