bluuebunny/crossref_metadata_2025 huggingface dataset:
Ontogeny of adenohypophyseal cells, pituitary gland development, and structure in adults of Astyanax lacustris (Teleostei, Characidae): an emerging Neotropical model fish species
Authors: Branco Giovana Souza , Cassel Mônica , Chehade Chayrra , Camargo Marília Paiva , Dias Gisele C. Melo , Borella Maria Ines , de Jesus Lázaro Wender Oliveira
Published: December 2024

Pituitary gland morphogenesis and the ontogeny of the adenohypophyseal (AH) cells of Astyanax lacustris are presented herein. This Characiformes species shows great ecological and commercial importance, and it has been increasingly used as a biological model. The first AH cells of A. lacustris were detected at 1 dah by the immunostaining of prolactin (PRL) producing cells. The morphology of the gland presented changes in shape throughout the development, starting elongated but more oval at the end. The neurohypophysis was differentiated at 3 dah, along with the identification of adrenocorticotropic hormone (ACTH), melanotropic hormone (MSH), thyroid-stimulating hormone (TSH), and follicle-stimulating hormone (FSH) producing cells. Identification of the immunoreactive cells to anti-luteinizing hormone (LH), anti-somatolactin (SL), and anti-growth hormone (GH) antibodies occurred at 5 dah. At 20 dah, an increase in pituitary size and the presence of the pituitary stalk were observed. At 60 dah, the pituitary already had the same shape and distribution of AH cells seen in the adult. The ontogeny of adenohypophyseal cells in A. lacustris corroborates the heterogeneity in the appearance of these cell types in teleosts and suggests that these hormones actively participate during the post-hatching development of this species, even before the establishment of all endocrine axes. Our findings contribute to understanding the morphogenesis of the hypothalamic-pituitary axis in South American teleosts, providing essential data for the development of future studies related to pituitary gland morphophysiology under normal or experimental conditions.
Investigation of Castor-oil Foam Adhesion on Aluminium Through Single-lap Tests
Authors: Nogueira Luís Felipe Cabral Diogo , Santos Júlio Cesar dos , Panzera Túlio Hallak , Santos André Luís dos , Freire Rodrigo Teixeira Santos
Published: December 2024

This work investigates the adhesion of a castor-oil-based polyurethane (PU) biofoam to the surface of 1200 aluminium. The foam is fabricated using water as the blowing agent. The apparent shear strength, joint toughness and adherent strength of single-lap joints are assessed following the ASTM standard D1002. 3D-printed moulds are developed for sample preparation. The study evaluates three different bonding strategies related to polymer curing: (1) Simple Cure, (2) Co-Cure with Adhesive Layer and (3) Direct Bonding. The Simple Curing method is conducted by expanding the PU biofoam in the mould cavity in contact with the aluminium sheets. In the second method, a layer of castor-oil PU resin is previously applied to the internal aluminium surfaces before pouring the water-PU foaming mixture. The foaming process thus occurs inside the mould as in (2), with the additional co-cure of the adhesive PU resin layer on the aluminium sheets. In the direct bonding method (3), a slab of previously cured foam is bonded to the aluminium faces using a layer of castor-oil PU resin previously applied to the internal metallic surfaces, as in (2). This study is motivated by a subsequent study on foam-core sandwich panels, in which the best face-core bonding strategy will be used.
Development of an environmentally benign and stability-indicating assay and related substances RP-HPLC method and quantification of metronidazole in pharmaceutical formulations
Authors: Kulkarni Mrunalini , More Pranay
Published: December 2024

An antibiotic drug used to treat various bacterial infections such as skin, stomach, liver, joints, brain, vagina, spinal cord, lungs, heart or bloodstream. Different formulations like tablets, capsules, injections, creams, and ointments are available as commercial products. A concise, accurate, and reliable isocratic reverse-phase high-performance liquid chromatographic (RP-HPLC) method was designed to determine metronidazole drug substance in finished dosage forms quantitatively. This route ensures a shorter run time for elution while attaining consistent retention time for accurate results. This study developed a greener approach using Isopropyl alcohol (IPA) as a solvent.
This study employs a simple, specific, linear, accurate, and precise reverse-phase liquid chromatographic method to quantify Metronidazole's main component and assess the metronidazole-related process and degradation impurities in finished drug formulation. The Chromatographic separation was accomplished using a Water Symmetry C18 column with 100 mm x 4.6 mm dimensions and a particle size of 3.5 μm. The mobile phase, consisting of Isopropyl alcohol and water (20:80 v/v), was employed at a 1.000 ml/min flow rate with an injection volume of 10 μl. The column oven temperature was set at 30 °C, while the autosampler temperature was maintained at 25 °C. Wavelength detection was configured at 315 nm, resulting in a retention time of approximately 2.4 min for metronidazole.
Similarly, to quantify the organic impurities, the same chromatographic conditions were used in the related substances method except for altering the column using the Zorbax, SB, C8 with dimensions of 150 mm x 4.6 mm and a particle size of 3.5 μm.
In this report greener approach was implemented to develop a promising method that will reduce the difficulties associated with other reported methods similar to tedious in use, less sensitive, costly, etc. As the run time of the method is reduced, the solvent requirement is also reduced making the method greener. Further, this method was employed to assess the force degradation of metronidazole FPs. which demonstrated metronidazole Impurity-A and unspecified impurities were accurately quantified under several ICH-recommended stress conditions like hydrolytic, oxidation, and thermal.
Unlocking the Therapeutic Potential of 1,25(OH)₂D₃: Targeting Ferroptosis to Alleviate Lumbar Intervertebral Disc Degeneration
Authors: Li Qiang , Peng Jing , Ding Fan
Published: December 2024

Lumbar intervertebral disc degeneration (LIDD) is a primary cause of low back pain, a condition with significant global health and socioeconomic impacts. Recent studies have highlighted the role of ferroptosis, an iron-dependent form of programmed cell death, in nucleus pulposus (NP) cells degeneration. This study investigates the protective effects of 1,25(OH)₂D₃, the active form of Vitamin D, on LIDD by targeting ferroptosis. Our findings demonstrate that 1,25(OH)₂D₃ effectively suppresses ferroptosis in nucleus pulposus cells by reducing lipid peroxidation, restoring glutathione levels, and enhancing antioxidant defenses. Mechanistically, 1,25(OH)₂D₃ exerts its effects through activation of the Vitamin D receptor (VDR) signaling pathway, which regulates key ferroptosis-associated molecules such as GPX4 and SLC7A11. These results reveal the therapeutic potential of 1,25(OH)₂D₃ in mitigating LIDD, offering a novel approach to suppress ferroptosis and preserve intervertebral disc function.
A Pineal Region Meningioma Presenting with Acute Subarachnoid Hemorrhage: A Case Report and Literature Review
Authors: Alborihi Soliman Noman Abdullah , shamsaddeen Soliman , Nasher Abdulgany , Al-Kharazi Khalid , Alborihi Edress Noman Abdullah
Published: December 2024

Background and Importance:
The primary aim of this study is to present a rare case of a pineal meningioma that presented with subarachnoid hemorrhage.
Case Presentation:
A 54-year-old male patient presented with a headache but no other neurological symptoms. He had experienced a sudden severe headache, memory impairment, loss of consciousness, and vomiting 13 days prior, leading to his admission to the ICU where he was diagnosed with subarachnoid hemorrhage. Upon arrival at the Pioneer Doctors Center, the patient exhibited slightly elevated blood pressure but showed no significant neurological deficits. He was cooperative, conscious, and oriented, scoring 15/15 on the Glasgow Coma Scale. His medical history included occasional headaches over the past six months. Imaging studies, including brain CT angiography and MRI, revealed a well-defined mass in the pineal region, compressing nearby structures. The patient underwent a right occipital interhemispheric transtentorial approach for tumor resection. Post-surgery, he experienced blurred vision but no neurological deficits. His condition improved significantly, and he was discharged two days later. Histopathological analysis confirmed a spindle cell tumor without atypia or necrosis, indicating a benign nature. Fourteen articles were found on PubMed. After excluding two non-English articles, 12 were screened, but none mentioned "meningioma" indicating a lack of relevant literature.
Conclusion:
Pineal tumors can present with subarachnoid hemorrhage, and surgical resection yielded a favorable outcome.
Defence Expenditure and Economic Growth: A Cross-Country Analysis of Peaceful and Conflict-Prone Countries
Authors: Arya Narendra Kumar , Pradhan Kailash Chandra , Mohapatra Sonali Madhusmita
Published: December 2024

This study uniquely examines the relationship between GDP growth and several key variables, including gross fixed capital formation (GFCF), secondary school enrollment, military expenditure, and innovation (measured by patents), in 13 peaceful countries and 8 conflict-prone countries from 2007 to 2022, as categorized by the Global Peace Index (GPI). To evaluate long-run effects, the analysis utilizes panel fixed-effects models, panel regression with Driscoll and Kraay standard errors, and the Generalized Method of Moments (GMM). The findings from the panel regression models show that GFCF strongly boosts GDP in peaceful nations, with weaker effects in conflict-prone regions. While education is not a significant driver in peaceful countries, it is vital for growth in conflict-affected areas. Military spending has minimal impact in peaceful nations but significantly hampers growth in conflict-prone countries. Innovation, indicated by patents, contributes positively to economic growth across all countries. The panel ARDL and asymmetric ARDL models show that innovation drives short-run growth in peaceful countries, while military expenditure inhibits it in conflict-prone regions. Long-run findings confirm that GFCF is critical to growth across all nations. Policy recommendations include reducing military spending, fostering education, promoting innovation, and ensuring stable governance.
JEL Classification: O11, O31, O57
Novel detection of Theileria equi and Babesia caballi in Hippobosca equina from horses in Spain
Authors: Dorrego-Rodriguez Abel , Gago Paloma , Olvera-Maneu Sergi , Jose-Cunilleras Eduard , De Cárdenas Lucía , Mantje Erik , Raez Alejandra , Gonzalez Sergio , Cruz-Lopez Fatima
Published: December 2024

Background
Hippoboscid flies are obligate hematophagous Diptera that infest mammals and birds worldwide. Hippobosca equina, commonly known as the forest fly, primarily affects horses and is considered both a mechanical and/or biological vector of various bacteria, viruses, and protozoa. Equine piroplasmosis (EP) is a tick-borne disease caused by three intra-erythrocytic hemoprotozoans: Theileria equi, Babesia caballi, and the recently identified species Theileria haneyi. To date, no studies have reported the detection of any Piroplasmida in H. equina. This study provides the first evidence of the presence of T. equi and B. caballi in forest flies infesting horses in endemic areas, identified using molecular techniques.
Methods
A total of 170 forest flies were collected from 35 Equidae across five locations in Spain (Segovia, Madrid, Toledo, and Menorca Island). Blood samples for equine piroplasmosis (EP) testing were drawn from 27 examined horses. All insects were identified both morphologically and molecularly, and genomic DNA from each fly and their equine host blood samples was screened for EP using real-time and nested PCR. Phylogenetic analyses were performed on all obtained T. equi and B. caballi sequences.
Results
All collected hippoboscids were identified as H. equina using a stereomicroscope and taxonomic keys, as well as by sequencing the mitochondrial cytochrome oxidase subunit 1 (COI) gene. Molecular screening detected T. equi DNA in 19 of 170 (11.2%) collected forest flies and B. caballi DNA in 2 of 170 (1.2%). All EP-positive flies were collected from EP-positive horses, with sequences from the flies and their equine hosts being identical. Two distinct T. equi and two B. caballi sequences were identified.
Conclusions
This study is the first to report the detection of T. equi and B. caballi in H. equina collected from horses. Given that approximately one-quarter of the flies sampled from EP-positive horses tested positive for the disease, sampling forest flies could be a practical method for detecting equine piroplasmosis in feral horse populations. Experimental transmission studies are required to assess the vector competence of H. equina for EP and other equine diseases.
Identification of Collided Vehicles in Indian Traffic Accidents using Hierarchical Deep Learning Framework
Authors: Porwal Shrusti , Khandelwal Yash , Malik Mukul , Singh Preety , Bansal Anukriti
Published: December 2024

In Intelligent Transportation Systems (ITS), accurately detecting accidents and identifying the vehicles involved is crucial for assessing accident severity. This paper focuses on the challenge of vehicle identification in accidents on Indian roads. We introduce a hierarchical detection model where an image is first analyzed for accident detection, and if an accident is detected, it is further processed to identify the involved vehicles in collision. We implemented various YOLOv8 model variants for accident and vehicle detection, finding that YOLOv8m performed best with an F1-score of 0.824 for accident detection and 0.827 for vehicle detection. The outputs of these detection units are integrated to identify collided vehicles, achieving an F1-score of 0.716 for this task.
Effects of maize/soybean intercropping on soil nitrogen mineralization and fungal communities
Authors: Liu Yalin , Fan Yuanyuan , Kuzyakov Yakov , Dai Jie , Zhang Chaochun , Li Chunjie
Published: December 2024

Aims
Maize/soybean intercropping has many advantages in soil nitrogen (N) use compared with monocultures. However, whether fungi increase the mineralization of soil organic N in intercropping remains unknown. We hypothesized that the fungal-mediated N mineralization in intercropping increases soil mineral N.
Methods
Soil was sampled in a 13-year field experiment with monocultured maize, monocultured soybean and maize/soybean intercropping without N input (N0) and with 180 kg N ha− 1 input (N180). The net N mineralization, N mineralization-related enzymes (urease and protease) and fungal communities were analyzed to show whether N mineralization occurred and the role of fungi in N mineralization.
Results
Based on the long-term experiment, the redundancy analysis showed that the soil chemical properties and enzyme activities explained 67.92% of the total variation of fungal communities. Intercropping increased the net mineral N content by 1.6 times compared to monocultured maize, mainly due to the increase in net ammonium content, the richness and diversity of fungal communities were not affected by intercropping under N0. There is no correlation between the net mineral N content and the relative abundance of fungal communities in different crop systems, but the net mineral N content was increased with the relative abundance of Glomeromycota under N180 (p = 0.04).
Conclusion
Maize/soybean intercropping increased the net N mineralization without affecting the soil fungal communities under no N input. The increased relative abundance of Glomeromycota under N input has potential to increase net N mineralization regardless of crop systems. This study provides evidence of N mineralization driven by intercropping under no N input. However, further research is needed to explore the microbial mechanism of N mineralization.
Fundamental spatiotemporal studies in heterogenous fire Spread: Instability Mechanisms and Dynamic Mode Selection
Authors: Malhotra Vinayak , Selvakumaran Thunaipragasam
Published: December 2024

Severe issues related to the fire-spreading phenomenon have led researchers worldwide to try different approaches for simplification. The increase in fire-related accidents has escalated the need for better operating solutions. The work presents, experimental simulations conducted on transitional fire spread to improve knowledge of spread of heterogeneous fires in both space & time. Homemade matchsticks were used as pilot fuel and external energy sources. Different configurations were tested, at varying surface orientations with a fixed number of external energy sources per direction. The effect and spreading phenomenon were observed in pilot fuel ignition and change in spreading rate with insight into localized & global burning. To gain true replication, experiments were conducted on dynamic models linear time-invariant (LTI), linear time- variant(LTV), & effect of spatial non-linearity was studied on non-linear dynamic models viz., NLTI (Non- linear time-invariant) & NLTV (Non-linear time variant) to determine spreading fire behavior & features. Additionally, important probable like, effect of phosphate was examined. The results were compared with single fuel burning to get better insight into external heat source & heat sink effect in both singular & coupled modes. The results reflect turbulent nature of fire spread & disorderly burning process. The spread rate analysis highlights distinct heat source & sink effect, uncertainty involved with collective burning along with combustion instability in form of irregular energy transfer. The results can be utilized in designing effective fire suppressants & retardants within given fire safety norms.
Comprehensive study of Design attributes for sustainable packaging design: Analytical techniques and expert validation
Authors: Singh Taruna , Singari Ranganath M. , Singh Sumer
Published: December 2024

A significant shift toward incorporating sustainable practices into packaging design with the increasing concerns about environmental sustainability. Sophisticated frameworks or tactics are necessary to lessen the increasing environmental impact of packaging waste. However, there are numerous opportunities to reduce waste and use more sustainable packaging design (SPD) techniques despite these initiatives. To address the need for a holistic strategy, this study introduces a comprehensive approach to sustainable packaging design. This technique covers packaging systems and packaged goods across the entire supply chain starting from the producer to the final consumer. This is presented as a strategic blueprint that aims to achieve not only more efficient but also more sustainable. It will provide a holistic perspective based on identified attributes on what constitutes a sustainable packaging solution. The approach incorporates several distinct analytical methods that ensure cost-effectiveness. The methodology is intended to be a practical tool for the packaging Industry and designers who seek to enhance sustainability within their packaging systems. Experts were selected from industry, academia and entrepreneurial background to enhance robustness of the proposed methodology. Moreover, attributes of this framework were validated on the Kano model that analysed whether its strength and relevance possessed significant impacts towards sustainable packaging design. The findings of this research will contribute to the development of a comprehensive framework for sustainable packaging design. These attributes will offer valuable guidance to manufacturers, designers, and companies seeking to prioritize sustainability in their operations. By providing a structured approach to decision-making, it aims to empower stakeholders to make well-informed choices that align with environmental goals and improve the overall sustainability of packaging systems.
Characterization of the secondary structure, renaturation and physical ageing of gelatine adhesives
Authors: Pulidori Elena , Duce Celia , Bramanti Emilia , Birolo Leila , Cipolletta Brunella , Ioio Laura Dello , Bonaduce Ilaria
Published: December 2024

Animal glues have been used for centuries, but their popularity decreased in the 20th century with the rise of synthetic adhesives, leading to their current primary use in restoration. Despite this decline, gelatine, derived from denatured and partially hydrolysed collagen, has gained popularity in various applications. This study focuses on gelatinous glue samples derived from animal bone and hide tissues, examining their secondary structure and thermal properties to identify structure-property correlations. Infrared spectroscopy analysis has revealed differences in the secondary structures, with hide glues exhibiting more β-structures than bone glues, indicating a higher degree of aggregation. Thermogravimetric analysis and differential scanning calorimetry also have highlighted differences between hide and bone glues, showing that the latter are more hydrolysed. Furthermore, the calorimetric curves have showed different values of denaturation enthalpy thus indicating a different degree of gelatine renaturation. Additionally, the calorimetric analysis has demonstrated the physical ageing of gelatinous glue samples, a key factor in maintaining adhesive properties for long-term use under specific storage conditions. In a context prioritizing the use of waste biomass over fossil fuels, understanding the properties of gelatine in glues is crucial for enhancing their performance and promoting their adoption as sustainable alternatives to non-renewable adhesives.
UAV Mobile Channel Adaptation Using AI
Authors: Kharchenko Volodymyr , Grekhov Andrii , Kondratiuk Vasyl
Published: December 2024

The aim of this work is to implement the adaptation of Unmanned Aerial Vehicle (UAV) communication channel using Artificial Intelligence (AI). Simulation was provided on the base of original model for communication channel “Ground Control Station – Satellite Transponder – Aerial Relay Drone – UAV”, which was designed using MATLAB Simulink software. Dependences of the Bit Error Rate (BER) on Signal-to-Noise Ratio (SNR) for different data rates, BER on Ground Control Station antenna diameter and BER on “Satellite Transponder” and “Aerial Relay Drone” amplifiers nonlinearity were obtained and analysed. The program code for training a linear regression model for predicting BER based on the obtained data is presented. The trained model adaptively changes SNR to find the optimal value at different Data Rates. The BER, SNR, and Data Rate dependences on time during channel adaptation are plotted.
Metals and proteins like phytochelatin in mangrove in a tropical estuary impacted by zinc smelter industry residues, southeast, Brazil
Authors: Kütter Vinicius Tavares , Pires Alina Criane Oliveira , Costa Ingrid Tavares , Montes-Bayón Maria , Sanz-Medel Alfredo , Oliveira Cristiane Pereira , Machado Wilson , Filho Emmanoel Vieira Silva
Published: December 2024

Mangrove forests represent an important environment for the biogeochemistry process. They can act as a bioaccumulator of metals by removing from the sediment. Phytochelatins, on the other hand, play an important role in the plant's detoxification mechanism by absorbing metals that are not essential to its physiology. Sepetiba bay is historical higher metals impacted by zinc smelter industry residues. The aim of the study was evaluating the metals contamination and arsenic loke phytochelatin in mangrove and fern (leaves, flowers and branches and root) in the smelter industry residues site. The total element content in plants was determined by ICP-MS and the determination of phytochelatins was carried out by SEC-HPLC-ICP-MS. The highest concentration of As (34.81 mg kg− 1) was detected in the leaves of the fern. Zn reached 287.91 mg kg− 1 in the roots and Cd did not exceed 3 mg.kg− 1 in the plant compartments. High concentrations of As in mangrove were reported only in flowers (6.1 mg kg− 1). The metals concentrations indicate a dilution gradient from the Cia Mercantil Ingá waste to bay. The mangrove in channel Arapucaia, showed highest concentrations of Fe and Mn can be are related to the influence of drainage from the ore port and coal terminal. In fern species, biomolecule analyzes demonstrate the existence of two different chemical species of As in the plant structure, while for Mangrove, three chemical species were found in the leaves and other two in flowers and branches.
Vernetzungs- und Selbstorganisationskompetenzen durch Working Out Loud™ fördern
Authors: Meißner Anne , Klatt Thomas , Schlieper Nora , Dotz Stefanie , Knackstedt Ralf
Published: December 2024

Für die Wirtschaft wurden mit Working Out Loud™ (WOL™) und ähnlichen Methodenverbünden Angebote gestaltet, mit denen Fachkräfte ihre Vernetzungs- und Selbstorganisationskompetenzen weiterentwickeln. Aufgrund der Bedeutung dieser Kompetenzbereiche wird WOL™ daraufhin untersucht, wie es sich im Hochschulkontext anwenden bzw. adaptieren lässt. Die Studie basiert auf der wissenschaftlichen Begleitung einer neu eingeführten Lehrveranstaltung an einer deutschen Universität. Leitfragenbasierte Fokusinterviews mit studentischen Teilnehmenden bilden die wesentliche methodische Basis. Im Ergebnis zeigen sich beachtliche Potenziale und auch wichtige Entwicklungsbedarfe des innovativen Lehrformats.
Isolamento de leveduras, produção e caracterização de hidromel
Authors: Mussato Vânia Casari , Coppede Juliana da Silva , Marins Mozart de Azevedo
Published: December 2024

O hidromel é uma antiga bebida fermentada, produzida a partir da fermentação da mistura de mel e água. Embora o hidromel não seja tão popular quanto outras bebidas fermentadas, como cerveja e vinho, há uma crescente demanda pelo produto nos últimos anos no Brasil. Este estudo teve como objetivo utilizar leveduras isoladas do mel e de resíduos de hidroméis para produzir e caracterizar o hidromel de acordo com a legislação vigente. Na primeira etapa do estudo, foram isoladas leveduras. Em seguida, o material genético dessas leveduras foi extraído, purificado e sequenciado. O resultado do sequenciamento revelou a presença de duas espécies de leveduras (Saccharomyces cerevisaie e Rhodotorula mucilaginosa). As leveduras foram submetidas a teste piloto de crescimento em meio de cultura e mosto de mel, e mostraram crescimento em ambos. A partir da escolha de três leveduras, o processo de fermentação do mosto de mel e água foi realizado sem suplementação nutricional. Os resultados físico-químicos mostraram que o hidromel produzido a partir das leveduras utilizadas está em conformidade com os parâmetros estabelecidos pela legislação. Foram realizados testes de análise sensorial com consumidores não treinados no produto. Os resultados dos testes de aceitação e ranqueamento não apresentaram diferenças significativas entre as amostras de hidromel, demonstrando que não haver preferência por uma amostra específica. Contudo, o resultado do teste de intenção de compra, comprovou que o produto tem potencial de expansão no mercado consumidor.
Intersecções entre subjetividade e matemática: uma revisão sistematizada de literatura
Authors: Matos Efraim de Alcântara , Brandão Jorge Carvalho
Published: December 2024

Neste trabalho busca-se trazer apontamentos sobre os modos de subjetivação dos sujeitos atravessados pela matemática em pesquisas de pós-graduação desenvolvidas no Brasil. Para isso, construiu-se um estado do conhecimento das pesquisas publicadas em duas bases de dados, BDTD e CAPES, no intervalo de tempo que vai de 1981 a 2023. A investigação deu-se com procedimentos ancorados na Síntese Qualitativa. De 468 trabalhos que retornaram com a string de busca, 41 foram selecionados e analisados, apontaram para a subjetividade como uma constituição de si e como práticas dos sujeitos, para os modos de subjetivação construídos a partir das relações com o Outro, e para a existência de diversas matemáticas, sejam elas curricularizadas escolarmente ou não. Apontam também para uma subjetividade construída a partir da linguagem matemática contribuindo para a produção de sujeitos. Indica-se a necessidade de construção de cartografias da subjetividade de sujeitos envolvidos nos processos de ensino de matemática que se (trans)formam diariamente.
Measuring factors affecting consumer attitudes toward metaverse adoption: Islamic banking services setting
Authors: Alhanatleh Hasan , Khaddam Amineh , Alzghoul Amro
Published: December 2024

Adopting metaverse technology in the banking sector is generating considerable interest. Investigating customers’ behavior is considered a primary element in adopting metaverse technologies in banking settings. This study combines the Trust Theoretic Model, Task-Technology Fit Model, and theory of planned behavior to explore consumers’ intentions to adopt metaverse Islamic mobile banking services in Jordan. Based on the Structural Equation Modeling (SEM) approach, the results using an electronic survey of 391 metaverse consumers among metaverse Islamic mobile banking services show that consumer trust based on its priors (perceived risk, perceived reputation, service quality, and perceived regulatory support) has a significant influence on consumer behavior intention at a significant P-value level (< 0.001). Furthermore, the results affirm that Task-Technology Fit plays a significant role in consumer behavior intention at a significant P-value level (< 0.001). Moreover, consumer behavior intention has a significant influence on consumers’ decision to adopt metaverse Islamic mobile banking services in Jordan at a significant P-value level (< 0.001). The findings of this study present critical insights for Islamic bank management in Jordan, assisting in developing their metaverse Islamic mobile banking, maintaining a strong relationship with consumers, and fostering consumer experiences. This study highlights the significance of adopting metaverse technologies in Islamic mobile banking services.
The role of universities in ensuring energy efficiency and sustainability: Investigating the link between UI GreenMetric ranking and countries’ sustainability indicators
Authors: Smolennikov Denys , Raboshuk Alina , Drebot Oksana , Oleksich Zhanna , Huliaieva Liudmyla
Published: December 2024

The article analyzes the role of universities, assessed through the prism of the UI GreenMetric World University Rankings (UI GreenMetric) methodology, in ensuring energy efficiency and sustainability of the national economy. For this purpose, UI GreenMetric results, systematized by country and region, were used, as well as data for 2017–2022 on countries’ progress in achieving SDG 7 and the national level of primary energy intensity. The analysis of trends in the development of sustainable universities according to UI GreenMetric shows regional differences: on average, the highest scores in the ranking are given to universities in OECD countries and East and South Asia, and the lowest – to Sub-Saharan Africa and Eastern Europe & Central Asia. A positive correlation (from 13.9% to 18.7% of the variation) was found between the activities of universities and the countries’ progress in achieving SDG 7, as well as a negative correlation with the energy intensity of the level of primary energy of these countries; this proves the participation of higher education institutions in ensuring the energy efficiency of national economies (the level of influence is much lower, the explanation of model variations is 2.4%-8.2%). The role of universities is not only to develop green campuses but also to increase research, create new educational programs, develop cross-sectoral cooperation and ‘living laboratories’ to implement sustainable development practices, and train future leaders capable of overcoming global energy challenges.
El estatuto ontológico de las formas en Merleau-Ponty. Una interpretación entre la epokhé y la Gestalttheorie
Authors: Libonati Fernando
Published: December 2024

Este artículo reconstruye la definición de “forma” ofrecida en La estructura del comportamiento. Luego se evalúan dos interpretaciones posibles: una realista y otra denominada “idealista”. Se sostiene que la primera no logra explicar la originalidad de los distintos tipos de formas y, en consecuencia, tampoco su carácter noemático (ser para una conciencia), mientras que la segunda resulta incompatible con el carácter descriptivo (no antropomórfico) de las Gestalten y conduce a una concepción de la naturaleza que resulta problemática respecto de la posición merleau-pontyana. Se propone una tercera interpretación: el concepto de “dialéctica”, tal como es utilizado por Merleau-Ponty para definir los órdenes físico, vital y humano, justifica una ampliación de los conceptos de “naturaleza” y de “conciencia” que permite conjugar el carácter descriptivo y noemático. Con base en ello, se concluye que las formas pueden ser identificadas con el proceso de fenomenalización de la naturaleza.
Recombinant chymosin of Camelus dromedarius in Pichia pastoris expression system: Purification and Enzymatic Profile
Authors: Antonova Elena , Firsova Natal'ya , Lengesova Natal'ya , Viktorov Denis , Achilov Atabeg , Torutanov Pavel
Published: December 2024

Natural chymosin production is an expensive and complex process associated with ethical issues. The article introduces recombinant chymosin Camelus dromedarius (rChn-Cam) isolated from a P. pastoris expression system and optimized for different nutrient media at different zeocin concentrations. The sequence of prochymosin gene was obtained from NCBI BLAST. GS115/his4 P. prastoris served as a producer strain. The pPICZ(alpha) B vector with the AOXI promoter made it possible to construct the expression cassette. The experiment involved methods of genetical engineering and strain cultivation. The recombinant His-Tag-labelled proteins were isolated by the method of metal-affinity chromatography and analyzed using PAG electrophoresis and Western-blot analysis. The molecular weight was determined by MALDI-TOF MS while the concentration was defined spectrophotometrically. The shuttle expression plasmid pPICZ(alpha)B/proCYM_camel_pp_IDT revealed that the cell mass expansion of P. pastoris GS115/his4 (Mut+) should be performed with a preliminary introduction of 0.5% methanol. After the transformation of P. pastoris GS115/his4 and obtaining a strain-producer of P. pastoris/pPICZ(alpha)B/proCYM_camel_pp_IDT, the rate of cell mass gain started to correlate with the zeocin concentrations in two different media. Medium YPD was not fornified and contained 50, 100, and 200 μg/mL zeocin. MediumYPD was fortified with 0.00004% biotin and 1% glycerol and included 50, 100, and 200 μg/mL zeocin. The strain-producer grew better in the medium with a zeocin concentration of 50 μg/mL. The mass of rChn-Cam was 35.673 kDa after isolation and purification. When the pH of the substrate rose from 5.0 to 6.5, the coagulation activity decreased by 24%. The thermal inactivation threshold of rChn-Cam was 40–45°C. The unit of coagulation activity decreased as the zeocin concentration went up. The rChn-Cam concentration was in inverse correlation with the substrate coagulation time. In this research, the rChn-Cam obtained in the expression system of P. prastoris proved to be a good alternative to rChn used in the cheese industry.
Rewriting Family Narratives in Classic Epics Through the Webtoon Princess Bari : Focusing on the Kongjwi Patjwi, Janghwahonglyun, the Sun and the Moon
Authors:   Dong Nam Eo-Mun-Hak-Hoi, Park YangRi
Published: December 2024

The webtoon Princess Bari is a work that adapts and reconstructs traditional narratives. This paper aims to explore how Princess Bari restructured the traditional family narrative to reflect contemporary meanings. In the webtoon, the stepmother, who is typically portrayed as a villain in traditional narratives, is depicted as a character who genuinely loves her stepchildren. Conversely, the idealized image of motherhood is challenged. The mothers in Kongjwi Patjwi and The Sun and the Moon are sometimes portrayed as being wounded, struggling, and even resenting or mistreating their own children, depending on the circumstances. The webtoon also centers on conflicts that are frequently addressed in contemporary society, such as conflict with in-laws, sibling rivalry, conflict with extended family, and domestic violence, ultimately leading to the disintegration of problematic families. The trauma resulting from these conflicts often persists and is passed down through generations, but Princess Bari offers hope for overcoming these traumas and moving toward a new future. Unlike the original narrative where family conflicts are resolved and the family is restored, Princess Bari diverges by presenting a new path after family dissolution.
Traditional narratives, as foundational sources for cultural content, have been garnering increasing attention across various fields. Princess Bari stands out for modernizing traditional stories, offering fresh interpretations that resonate with contemporary readers. Further exploration of how traditional stories are reimagined in modern popular culture is essential for future research.
A Study on the Usage Patterns of Intentional Connective Endings in Korean: Focusing on ‘-(eu)ryeo, -(eu)ryeogo, and -goja’
Authors:   Dong Nam Eo-Mun-Hak-Hoi, Yu InSeon
Published: December 2024

This study investigates the differential usage patterns of the Korean intentional connective endings '-(eu)ryeo', '-(eu)ryeogo', and '-goja'. The research analyzed the semantic preferences of 3,000 examples extracted from , comprising 200 samples each from textbooks, literature, newspapers, magazines, and informational texts. Results indicate that '-(eu)ryeogo' differs from the other two connective endings at the superordinate conceptual level of semantic preference, while '-goja' exhibits distinctive features at the subordinate level. Furthermore, a register-specific semantic preference analysis revealed varying usage patterns for each connective ending across different text types. These findings contribute to a deeper understanding of the three connective endings and provide valuable insights for Korean language education and learning. The study's methodological approach of examining semantic preferences offers new perspectives on the subtle functional differences between seemingly synonymous grammatical forms, potentially informing future research in Korean linguistics and language pedagogy.
ACONSELHAMENTO NUTRICIONAL PARA GESTANTES ASSISTIDAS DURANTE A PANDEMIA POR SARS-COV-2 EM UMA UNIDADE DE SAÚDE DA FAMÍLIA
Authors: Oliveira Larissa Ferreira de , Silva Camila Emille Reis da , Santos Cristiane de Jesus , Marinho Sônia Maria Oliveira Cavalcanti , Oliveira Clotilde Assis , Campos Renata  de Oliveira
Published: December 2024

Introdução: A abordagem multiprofissional durante o período gestacional inclui ações de educação alimentar e nutricional, tendo em vista que o estado nutricional adequado e uma alimentação saudável são fundamentais para a eficácia do sistema imunológico e prevenção de doenças crônicas e infecciosas. Objetivo: Relatar a experiência das autoras no aconselhamento nutricional de um grupo de gestantes, por meio do aplicativo WhatsApp®, no período de pandemia por SARS-CoV-2. Metodologia: Trata-se de um estudo descritivo, qualitativo, do tipo relato de experiência sobre a ação de extensão universitária desenvolvida pelo projeto “Aconselhamento Nutricional de Gestantes em Tempos de Covid-19”, realizado no período de junho a dezembro de 2020. Resultados: Participaram do grupo 28 mulheres em diferentes períodos da gestação. Foram realizadas 24 sessões grupais, com duração de duas horas semanais. A experiência foi avaliada na perspectiva das estudantes de Nutrição, docentes e gestantes que participaram do projeto, especialmente, no que tange à oportunidade de reconhecer os limites, as potencialidades e os desafios do aconselhamento nutricional on-line de grupos. Conclusões: A interação com as gestantes possibilitou o diálogo com a equipe do projeto e direcionou a trajetória metodológica, tornando as gestantes agentes ativas da prática assistencial.
RELAÇÃO DOS EFEITOS DOS PREBIÓTICOS E DOS PROBIÓTICOS NA PATOGÊNESE DA ANSIEDADE
Authors: Brito Fernando Cesar Rodrigues , Lima Beatriz Merencio de , Mota Emanuelly Silvino , Lira Sandra Machado
Published: December 2024

Introdução: Existe uma ligação entre a ansiedade e a microbiota intestinal, e pesquisas evidenciam que o uso de prebióticos e probióticos podem ser estudados como uma terapia alternativa para a ansiedade patológica. Objetivo: Esta revisão integrativa objetiva buscar estudos científicos que apresentam os potenciais efeitos benéficos dos prebióticos e dos probióticos sobre a ansiedade. Metodologia: Para a seleção dos estudos foram utilizadas as bases de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Sistema de Análise e Recuperação da Literatura Médica on-line (Medline), PubMed e Biblioteca Virtual em Saúde (BVS), trazendo artigos originais dos últimos 5 anos. Resultados: A ministração de alguns prebióticos e probióticos como exemplo a Bifidobacterium e os Lactobacillus por um período pré-definido, mostrou que o uso traz efeitos benéficos para a redução dos níveis da ansiedade patológica e podem ser eficazes em pacientes que possuem alguma comorbidade associada como a obesidade, o alzheimer, a diabetes. Conclusões: Os resultados encontrados pelos estudos demonstraram que após o uso de prebioticos e probioticos por um determinado tempo obtiveram resultados positivos na diminuição dos sintomas da ansiedade.
QUE FATORES ESTÃO ASSOCIADOS A UM MAIOR TEMPO DE ESPERA PARA ATENDIMENTO NOS CENTROS DE ESPECIALIDADES ODONTOLÓGICAS DO BRASIL?
Authors: Lima Luana Maria de Medeiros , Santos Sophia Queiroz Marques dos , Galvão Maria Helena Rodrigues , Oliveira Angelo Giuseppe Roncalli da Costa
Published: December 2024

Introdução: Apesar dos avanços da Política Nacional de Saúde Bucal (PNSB), iniquidades na utilização dos serviços odontológicos persistem, afetando grupos vulneráveis como populações rurais, idosos e pessoas de baixa renda e escolaridade, que enfrentam barreiras significativas de acesso e, consequentemente, piores condições de saúde. Fatores socioeconômicos, tempo de espera e localização geográfica dos centros de saúde, bem como desigualdades sociais a nível municipal, influenciam a utilização desses serviços, revelando a necessidade de intervenções para garantir acesso equitativo. Embora a atenção primária seja mais acessível a esses grupos, a atenção especializada tende a favorecer indivíduos com maior capital social, sugerindo um processo de universalização seletiva. Objetivo: O estudo avaliou os fatores individuais e contextuais associados ao tempo de espera para iniciar o tratamento nos Centros de Especialidades Odontológicas (CEO). Metodologia: As variáveis independentes individuais referem-se aos usuários, enquanto as variáveis contextuais estão associadas ao município do Centro de Especialidades Odontológicas (CEO), utilizando dados secundários do banco de avaliação externa do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-CEO) do primeiro ciclo, com uma amostra de 8.898 usuários provenientes de 935 CEOs. Resultados: Observou-se que o tempo de espera para atendimento superior a um mês é significativamente maior entre usuários com escolaridade limitada ao ensino fundamental (Razão de Prevalência [RP] = 1,24), aqueles com renda familiar de até um salário mínimo (RP = 1,39) e usuários sem renda (RP = 1,52). Em nível municipal, um maior tempo de espera foi associado a municípios com menor renda per capita média, especificamente para aqueles com renda de até R$ 471,12 (RP = 1,99). Conclusões: Esses dados indicam a presença de desigualdades significativas no tempo de espera por atendimento nos CEOs, ressaltando a necessidade de intervenções que promovam equidade no acesso aos serviços odontológicos.
Palavras-Chave: Especialidades Odontológicas; Atenção Secundária à Saúde; Avaliação em Saúde; Serviços de Saúde Bucal; Acesso aos Serviços de Saúde.
RECURSO CINEMATOGRÁFICO NO ENSINO DE SUSTENTABILIDADE E SAÚDE COLETIVA NA GRADUAÇÃO MÉDICA
Authors: Oliveira Márcia Farsura de , Ferreira Lindisley Gomides
Published: December 2024

Introdução: Os recursos cinematográficos têm sido importantes ferramentas pedagógicas que atuam de forma instrutiva, analítica e prática, conforme sugerido pelas Diretrizes Curriculares Nacionais do Curso de Graduação em Medicina de 2014. Na formação médica, o cinema propicia que o discente reformule princípios humanistas preexistentes, fundamentais para o relacionamento interpessoal, em favor do bem-estar dos pacientes, das comunidades e dos territórios. Objetivo: Apresentar um relato de experiência de metodologia ativa utilizada com estudantes do estágio curricular obrigatório em saúde coletiva de uma Instituição de Ensino Superior privada, localizada no interior do estado de Minas Gerais, de acordo com a abordagem da temática do desenvolvimento territorial sustentável. Metodologia: Foi utilizada metodologia ativa de análise e reflexão de documentário em horário de aula na graduação médica, com posterior discussão oral com aproximadamente dez alunos da turma do Internato em Saúde Coletiva. Também foi proposta a redação de uma resenha com reflexões sobre territórios sustentáveis e saúde coletiva. Resultados: Destacou-se a relação entre sustentabilidade, democracia, direitos humanos, justiça social e qualidade de vida, defendendo que esses elementos impulsionam a cidadania e combatem desigualdades e degradação ambiental. Após refletir sobre o documentário, foi discutido o uso de ferramentas como o Mindfulness para auxílio na conscientização do consumo, evitando desperdícios. Conclusões: O uso do recurso cinematográfico mencionado como metodologia ativa revelou a importância de conscientizar os futuros médicos sobre sustentabilidade e equidade social.