bluuebunny/crossref_metadata_2025 huggingface dataset:
MULTIMODAL TREATMENT IN PEDIATRIC ORBITAL RHABDOMYOSARCOMA: ABOUT 8 CASES
Authors:   RadiothÃ©rapy Department, Nationalinstitute of Oncology, University of Mohammed V of Rabat., Benmessaoud H. , Ahmut H. ,   RadiothÃ©rapy Department, Nationalinstitute of Oncology, University of Mohammed V of Rabat., Bouhia H. ,   RadiothÃ©rapy Department, Nationalinstitute of Oncology, University of Mohammed V of Rabat., Kacemi H. El ,   RadiothÃ©rapy Department, Nationalinstitute of Oncology, University of Mohammed V of Rabat., ElMajjaoui S. ,   RadiothÃ©rapy Department, Nationalinstitute of Oncology, University of Mohammed V of Rabat., Kebdani T. ,   RadiothÃ©rapy Department, Nationalinstitute of Oncology, University of Mohammed V of Rabat., Hassouni K. ,   RadiothÃ©rapy Department, Nationalinstitute of Oncology, University of Mohammed V of Rabat.
Published: February 2023

Rhabdomyosarcoma is the most frequent mesenchymal tumor in children, composed of cells with histopathological characteristics of striated muscle at different stages of embryogenesis. The orbital location accounts for about 10% of cases. Its prognosis has improved thanks to the progress of chemotherapy and new radiotherapy techniques.The aim of our study is to report the clinical and therapeutic characteristics of rhabdomyosarcomas of the orbit in children, and to present different complications of the treatment.
INDICATIONS FOR THYROID SURGERYEXPERIENCE OF THE ENT DEPARTMENTOF MOULAY ISMAÃL MILITARY HOSPITAL IN MEKNES (ABOUT 103 CASES)
Authors: Leila Rouimi , a Nadour , b Traibi , c Attifi
Published: February 2023

Introduction: The indications for thyroid surgery are currently well defined and specified in the consensus recommendations for the management of thyroid nodules, which would allow on the one hand to reduce the excessive number of thyroidectomies, and on the other hand would not allow a malignant lesion to evolve. Objectives: Our study aims to evaluate the epidemiological, clinical and paraclinical characteristics of patients who have undergone thyroidectomy and to discuss the different surgical indications. Patients and methods: This is a retrospective study spread over one year, from January to December 2019, involving 103 patients hospitalized for thyroid surgery, in the ENT (ear nose throat) department of Moulay Ismail military hospital in Meknes. Results: The average age of our population was 50.68 years and the sex ratio W/M was 5.86. The time to consultation was more than 2 years in half of the patients. The reason for consultation was cervical swelling in 88 cases, signs of hyperthyroidism in 27 cases and compression in 15 cases. All our patients have benefited preoperatively from a TSH assay and a cervical ultrasound. A cervico-thoracic scan was performed in all patients with plunging and/or compressive goiter. Cytopuncture could only be performed in 10 cases.Surgical indications were retained in case of suspected malignancy (56.31%) hyperthyroidism (26.22%), compressive goiter (14.56%), aesthetic discomfort (1.94%) and recurrent thyroid cyst (0.97%)The surgical procedure consisted of a total thyroidectomy in 81.5% of cases, a lobo isthmectomy in 8.7% of cases and secondary totalization in 9.7% of cases. The pathological study revealed thyroid cancer in 11.65% of cases. Postoperative follow-up was marked by the occurrence of a compressive hematoma in one patient, transient unilateral recurrent paralysis in 2 patients, transient hypoparathyroidism in 6 patients, and tumor recurrence in one case Discussion: Surgical indications have been proposed, primarily in case of suspected thyroid neoplasia, mainly based on clinical and ultrasound criteria. The cancer/benign tumor ratio was 13.2%. It was therefore important to develop the cytopuncture.Autonomous goiters/nodules and compressive and/or plunging goiters were the main other indications for surgery with low morbidity, but at the cost of permanent hypothyroidism. Conclusion: Surgery is the gold standard treatment for symptomatic thyroid goiters/nodules. However, its contribution must be constantly reassessed according to the evolution of new diagnostic procedures and alternative techniques.
SHARIAH COMPLIANCE EFFORTS AND APPROACHES IN MALAYSIAN ARMED FORCES ORGANISATION BY KOR AGAMA ANGKATAN TENTERA (KAGAT)
Authors:   Faculty of Defence Studies and Management, Universiti Pertahanan Nasional Malaysia, 57000 Sungai Besi, Kuala Lumpur, Wilayah Persekutuan, Malaysia., Jalal Burhanuddin , Mohd Nasir Badlihisham ,   Academy of Islamic Studies, Faculty of Social Sciences and Humanities, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Johor, Malaysia., Hafiz Safiai Mohd ,   Research Centre for Sharia, Faculty of Islamic Studies& Institute of Islam Hadhari, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Azraai Jamsari Ezad ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
Published: February 2023

The inculcation of Islamic values in administration was a policy introduced by the Government of Malaysia by the then Prime Minister, Dato Seri Dr. Mahathir Mohamad. This policy was a continuation of undertaken government efforts such as establishment of various Islam-based organisations and fortification of the then Division of Islamic Affairs in The Prime Ministers Department. In line with that, organisations under the Malaysian Armed Forces or Angkatan Tentera Malaysia (ATM) also undertook efforts towards inculcation of Islamic values in their respective organisations to erode influences of British army which are in contradiction to Malay and Islamic traditions. Establishment of Kor Agama Angkatan Tentera Malaysia (KAGAT or the Malaysian Armed Forces Religious Corps) in 1985 was one of the efforts towards conformance to shariah in the Malaysian Armed Forces. The objective of this study is to explore KAGATs efforts to fulfil the requirements of shariah compliance in organisations under ATM. Apart from that, it is an objective of this research to study undertaken approaches to implement conformance to shariah in ATM. This qualitative study employed a bibliographic research method and document reviews as a method for data accumulation while a thematic analysis method was used to analyse the data. Findings showed that efforts of shariah conformance were effectively implemented using suitable approaches. Shariah compliance had increased bringing about good impacts towards the success of KAGAT in dakwah in a continuous and more holistic manner in building a credible Malaysian Armed Forces which have a strong fighting capability as well as formidable spirituality. This study fills a gap in the literature on the aspects of shariah compliance and methods used by ATM as such studies have not been much explored by previous researchers.
A CASE OF MALE SLE: AN UNUSUAL PRESENTATION
Authors: H. Rajanna Avinash , S. Bellary Vaibhav , Teggihal Anagha
Published: February 2023

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune diseasein which tissue-binding auto-antibodies and immune complex depositioncause damage to multiple organs and systems.We report a rare case of SLE in a 31-year-old male patient. He has a past history of unprovoked deep vein thrombosis of right lower limb for 8 years, treated with anticoagulant therapy but not evaluated further. The patient went on to develop recurrent symptoms of fever, rashes and joint pains which were also overlooked. ANA profile and APLA antibodies were positive and the patient was diagnosed with SLE after 8 years since onset of symptoms. He now exhibits renal manifestations in the form of anasarca and proteinuria and CNS manifestations in the form of seizures. We attribute the severity of his current condition to the delayed diagnosis.
Efficacy of Ochna integerrima (Lour.) Merr leaf extracts against seedling growth of six important plants
Authors: Moh Seinn Moh , Noguchi Hisashi Kato-
Published: February 2023

Ochna integerrima (Lour.) Merr, a deciduous shrub in the family Ochnaceae, is a great source of active compounds and is used as a medicinal plant in tropical Asia, Africa, and America. Previous studies have focused on the pharmacological properties of O. integerrima; however, the allelopathic potential of this plant has not yet been identified. Therefore, this study was carried out with completely randomized design to determine the allelopathic potential of O. integerrima leaf extracts in six concentrations against the seedlings growth of dicots plants [garden cress (Lepidium sativum L.), lettuce (Lactuca sativa L.), and alfalfa (Medicago sativa L.)] and monocot plants [Italian ryegrass (Lolium multiﬂorum Lam.), timothy (Phleum pratense L.), and barnyard grass (Echinochloa crusgalli (L.) Beauv.)]. The results showed that the leaf extracts inhibited the seedling growth of all the test plants at concentrations ≥10 mg dry weight (D.W.) equivalent extract mL−1, except for the barnyard grass shoots. The concentrations needed for 50% inhibition (I50 values) of the shoot and root growth of the test plants were in the ranges 1.97–48.01 and 1.18–9.64 mg D.W. equivalent extract mL−1, respectively. The I50 values showed the roots of all the tested plants were more susceptible to the extracts than their shoots, except alfalfa. These findings suggested that the leaf extracts of O. integerrima may possess allelopathic substances which could be used as a source of bio-herbicide for reducing the weed burden in crop fields. Thus, more research is needed to isolate and identify the allelopathic substances in O. integerrima in order to produce bio-herbicide for weed management
Hydroponic kale: effects of row spacing and number of plants per cell on yield and quality
Authors: Noboa Caio Salvador , Lima Bianca Machado de , Bettan Silvia Raquel , Gupta Dorin , Bernardi Marta Regina Verruma- , Purquerio Luis Felipe Villani , Sala Fernando Cesar
Published: February 2023

The consumption of kale is increasing, and it is sold in bunches of adult leaves. However, there is the possibility of growing in bunches of young plants in a hydroponic system with several advantages, but different densities were not tested. The aim was to generate information on the hydroponic cultivation in NFT (nutrient film technique) of curly kale in bunches of young plants, with a study of spacing (0.07, 0.11, 0.15 and 0.20 m) and several plants per cell (one, two, three and four), aiming to improve the productivity, quality and homogeneity of kale. A split-plot experiment was executed in randomized block design, with four repetitions. Agronomic characteristics were measured, and bromatological and nutrient analyses were performed. Plant height and productivity were higher with smaller spacing. With fewer plants per cell, the leaf dimensions were higher and more homogeneous were the different plants of the same cell. With four plants per cell, it was recorded, on average, 19.3 g of fresh weight of shoot in the largest plant and 6.4 g in the smallest one. The bromatological and nutrient content was consistent with literature reports. Thus, the desired product in cultivating hydroponic kale in bunches of young plants is decisive for choosing spacing and numbers of plants per cell. Larger leaves can be harvested with fewer plants per cell than more plants per cell and vice versa. The use of smaller spacing increases productivity. The hydroponic system is technically viable to produce curly kale, providing plants with good nutritional quality.
Eastern Morocco Argania spinosa propagation and growth: A follow-up study
Authors: Azizi Salah-eddine , Mzabri Ibtissam , Mohammed Dalli , Noureddine Kouddane , Abdelbasset Berrichi , Nadia Gseyra
Published: February 2023

The Argan tree (Argania spinosa L) is an endemic species, located mainly in the southwest of Morocco, but also exists as a relic in the northeast of the country. It is a species of great biological, ecological and socio-economical importance. As part of the domestication of the Argan tree at the national and regional scale, a study was carried out which aims to optimize the mode of sexual multiplication of eastern Morocco Argan tree, by studying the effect of the nuts weight on the rate of imbibition, the rate of germination, the number of seedlings resulting from each nuts classes of weight, and the growth of the seedlings. The experimental treatment is mainly formed by three classes of nuts weight. The first class named W-1 is formed by nuts with a weight less than 2g. The second-class W-2 is characterized by nuts of a weight ranging from 2 to 3.5g. The last class is W3 and has a weight of over than 3.5g. The germination was conducted in a phytotronic room at a controlled temperature (26  2°C). While, the follow-up of the seedlings’ growth was carried out in a glass greenhouse, and the rate and kinetics of imbibition were performed in a separate experiment. The results indicated that the nuts were water permeable and the rate of imbibition was found to be proportionally related to weight and varies between 18.18 % W1 and 32.21% W3 after 48 hours. On the other hand, for the germination rate, the nuts of class W1 showed the highest germination rate (84.4%) followed by those of class W2 (72%) and finally class W3 (68.8%). However, Argan nuts could contain more than one kernel and produce more than one seedling per nut and this allowed to have a high number of produced plants and increased the germination rate in particular for the classes W2 and W3, (99.2% and 97.2%). The results also showed that the growth and the development of seedlings were proportionally related to the weight of the kernels.
Land tenure regularization and state land grabbing in the municipality of Paragominas, Eastern Amazon
Authors: Ramos Robson Jose Carrera , Lima Herdjânia Veras de
Published: February 2023

In the Amazon, the regularization of public and private lands is under discussion to reduce deforestation. However, this scenario is difficult due to land disorganization and divergent federal and state policies. The objective of this study was to analyze the importance of land data in federal and state public lands and private lands for the municipality of Paragominas, Eastern Amazon. In this study, we try to propose a diagnosis of land tenure structure, quantifying the Value of the Bare Land of the overlapping lands, state public lands on federal lands, as well as deforestation and forest conversion. The results showed that the area of federal publicly listed lands has drastically reduced. The reduced area is equivalent to the territory of Palestine, in the same database managed by the federal management agency. State public lands overlapped 16,153.32 ha on federal public lands, with a loss of US$5,529,927.57 for the federal government. Deforestation has increased on state public lands, driven by conversion to soy cultivation areas, and there is a trend towards stabilization of deforestation and agriculture on federal public lands
Productivity of some barley cultivars as affected by supplemental irrigation under rainfed conditions
Authors: Attia Mohamed Abd El-Hammed , Enin Moamen M. Abou El- , Tahoun Ayman M. Abou , Abdelghany Fatma I.M. , Serafy Rasha S. El-
Published: February 2023

Barley is widely cultivated in the northern coasts of Egypt and in the newly reclaimed lands. The goal of this study was response of some naked barley cultivars with high yield potential using supplemental irrigation under rain-fed conditions at Al-Kasr area, Marsa Matrouh, North-Western Coast of Egypt. The growth, yield, and drought-tolerance indices of Giza 129, Giza 130, and Giza 131, barley cultivars were estimated under rain-fed and supplemental irrigation regimes (SI0: rainfall only; SI1: two supplementally irrigations at tillering and heading stages; SI2: three supplementally irrigations at tillering, stem elongation, and heading stages). Agronomic traits including yield components and drought indices for the studied barley cultivars were assessed. The results displayed that Giza 131 gave a higher performance in most studied characters under rain-fed and irrigation regimes. Also, it produced the highest tolerance index (TOL), yield index (YI), harmonic mean (HM), stress susceptibility percentage index (SSPI), sensitivity drought index (SDI), mean productivity (MP), and geometric mean productivity (GMP). MP was positively correlated with YSI, GMP, DI, and HM. So, Giza 131 cultivar was identified as a drought-tolerant genotype. Moreover, the drought tolerance indices of TOL, YI, HM, SSPI, SDI, MP, and GMP are suitable for screening cultivars with high yields under stressed and non-stress conditions. The correlation analysis between the studied traits of barley indicated that highly significant positive correlation was obtained between number of spikes m-2 and grain yield. So, these traits are the most important components of the estimated grain yield of naked barley
EXPERIENCE IN THE DEVELOPMENT AND RESEARCH OF ALCOHOLIC BEVERAGES WITH REDUCED TOXIC POTENTIAL
Authors: Abramova I.M. , Kalinina A.G. , Golovacheva N.E. , Morozova S.S. , Gallyamova L.P. , Shubina N.A.
Published: February 2023

The aim of the work was to study the effect of a line of complex food additives in alcoholic beverages on the narcogenic potential of ethyl alcohol. To reduce the toxicity of ethanol alcohol, ingredients presumably possessing this ability were introduced into the formulations of alcoholic beverages. The results of the studies showed a decrease in the mortality and severity of ethanol withdrawal syndrome in animals treated with water-alcohol solutions, including complex dietary supplements.
USE OF NATURAL SOURCE OF SUGAR IN KVASS TECHNOLOGY
Authors: Permyakova Larisa , Sergeeva Irina , Smetanina D. E. , Lashickiy S. S.
Published: February 2023

The production of beverages, including kvass, of functional action is an important
direction in the food industry. The use of sucrose in the form of sugar syrup as the main source
of fermentable carbohydrates in the manufacture of kvass reduces the biological value of this
drink. The purpose of the work is to study the prospects of using sugar beet juice in the
manufacture of kvass. It is shown that the process of fermentation of kvass wort on sugar beet
juice in comparison with the use of sugar syrup proceeds more intensively (decrease in dry
matter by 17% more), which is also confirmed by stimulating the growth and reproduction of
yeast (an increase in the total number of cells by 1.4 times, budding individuals in 2 times) due
to the usefulness of the nutrient medium. Given these facts, as well as a positive tasting
assessment, we can conclude that it is possible to replace sugar syrup with sugar beet juice in
the production of kvass of increased biological value.
EMULSION PROBIOTICS IN TECHNOLOGIES OF ALIMENTARY CORRECTION PHYSIOLOGICAL CONDITIONS OF THE BODY
Authors: Rodionova N. S. , Popov E. S. , Zaharova N. A.
Published: February 2023

The paper shows the possibility of combining in a single food system the biomass of a
consortium of probiotic microorganisms and bioactive vegetable oils, which ensures more efficient
absorption and assimilation of micro- and macro-components. The resulting emulsion probiotic
products provide a significant increase in the preventive, therapeutic and biocorrective action of
bioactive oils from low-oil domestic raw materials, proven by numerous studies of physicians,
biologists, physiologists.
YEAST INACTIVATION BY ULTRASONIC TREATMENT
Authors: Romanenko V. O.
Published: February 2023

Purpose: to evaluate the possibility and prospects of using ultrasonic treatment for
yeast inactivation.
THE USE OF THE EXTRACT OF THE ORDINARY SKULLCAP TO OBTAIN AN ENRICHED CURD PRODUCT
Authors: Belashova O.V.
Published: February 2023

Objective: obtaining an enriched curd product containing an extract of the common skullcap
to expand the range of products that have a comprehensive therapeutic and preventive effect.
BIOETHICAL ISSUES OF VACCINOMICS
Authors: Tarabrin R. E. , Pyatigorec E. S.
Published: February 2023

Vaccinomics, as one of the areas of personalized medicine, can increase the effectiveness of
vaccines, including in epidemics. Nevertheless, it is accompanied by a cluster of bioethical issues.
The article explores possible bioethical difficulties associated with the development of personalized
vaccines: the matching of the research subject and the person receiving the vaccine; the problem of
confidential genetic data; equitable distribution of medical resources.
NON-TRADITIONAL WAYS OF USING VEGETABLE WASTE
Authors: Ustinov V. S.
Published: February 2023

Objective: talk about the potential of vegetable waste.
STUDY OF BIOCOMPATIBILITY OF PROBIOTIC STRAINS OF MICROORGANISMS IN ORDER TO CREATE A BIOLOGICALLY ACTIVE FOOD ADDITIVE
Authors: Faskhutdinova Elizaveta , Milentyeva Irina , Proskuryakova Larisa
Published: February 2023

The purpose of this work is to study the biocompatibility of probiotic strains Lactobacillus
plantarum B-1615, Lactobacillus brevis B-2429, Bacillus subtilis B-7918, Enterococcus faecium B5000 and Lactobacillus paracasei B-2430 to create a biologically active supplement. A drip technique
was used to study biocompatibility. It was found that biocompatibility is possessed by combinations of
strains Lactobacillus plantarum B-1615 and Lactobacillus brevis B-2429; Lactobacillus plantarum B1615 and Bacillus subtilis 21 B-7918; Lactobacillus plantarum B-1615 and Lactobacillus paracasei B2430; Lactobacillus brevis B-2429 and Enterococcus faecium B -5000; Lactobacillus brevis B-2429 and
Lactobacillus paracasei B-2430; Bacillus subtilis 21 B-7918 and Enterococcus faecium B-5000.
STUDY OF ANTIOXIDANT ACTIVITY OF MICROBIOTA OF KUZBASS TECHNOZEMS
Authors: Fotina Natalya , Asyakina Lyudmila , Milentyeva Irina , Serazetdinova Yu. R.
Published: February 2023

Active anthropogenic impact leads to the development of oxidative stress of agricultural
plants. To solve this problem, it is promising to use microbial biologics based on microorganisms resistant to various man-made pollutants and contributing to the production of phytostimulating substances.
FOOD INGREDIENTS OF A LIPID NATURE WITH VITAMINS D3 AND K2, STRUCTURED BY BEESWAX MONOESTERS
Authors: Frolova Yuliya , Sobolev Roman , Kochetkova Alla
Published: February 2023

Fats and oils are an essential part of a well-balanced diet. However, the food industry has
traditionally used hydrogenated oils containing saturated and trans-isomeric fatty acids to provide the
desired texture in fat-based foods. Structured edible oils (oleogels) are being considered to replace
chemically modified oils. Oleogels can be used not only as an alternative to solid fats and hydrogenated
oils, but also as carriers of biologically active substances. The aim of the study: a comparative analysis
of the properties of oleogels containing fat-soluble vitamins D3 and K2, structured with beeswax
monoesters, and oleogels structured with the initial beeswax to obtain enriched food ingredients of lipid
nature - an alternative to solid fatty products containing saturated and trans-isomeric fatty acids. As a
result of the studies, it was shown the influence of the gelator composition and the fat-soluble vitamins
D3 and K2 on oleogel properties.
ANTIOXIDANT ACTIVITY OF CHLORELLA VULGARIS EXTRACTS
Authors: Hil'sher M. S. , Vesnina Anna
Published: February 2023

This work is aimed at comparing the antioxidant activity of Chlorella vulgaris extracts with
each other.
microalgae, Chlorella vulgaris, extraction, antioxidant activity, antioxidants
PROSPECTS FOR THE USE OF ENDOGENOUS MICROORGANISMS FROM NATURAL SOURCES AS PRODUCERS OF BIOPESTICIDES
Authors: Horoshkina N. N. , Gordeeva L. A. , Voronina E. N.
Published: February 2023

The study of polymorphism of genes of dairy proteins of cattle allows us to objectively assess
the genetic potential of a herd of farm animals associated with milk productivity. The introduction of
DNA diagnostic methods into the practice of cheese-making enterprises can significantly improve the
quality of the product.
PROJECT SELF-MANAGEMENT OF DOCTORS IN KUZBASS
Authors: Carik G. N.
Published: February 2023

KOAV is a voluntary and self-governing public association of doctors. The purpose of the
activities of organizations is to unite citizens for practical solutions to scientific problems in the field of
medicine and health care.
INVESTIGATION OF THE QUALITY OF MILK VANILLA IODIZED COCKTAIL
Authors: Cvetkova D. P. , Lapteva N. G.
Published: February 2023

Mineral substances are necessary for the human body. Iodine deficiency is a global problem
at the moment. One of the ways to solve this problem is functional foods enriched with iodine. This
paper presents the results of an organoleptic evaluation of a new functional product – a vanilla
milkshake enriched with iodine.
Objective: to evaluate the quality of the milk vanilla iodized cocktail according to
organoleptic parameters.
PREDICTIVE AND PROGNOSTIC SIGNIFICANCE OF PALB2 GENE MUTATIONS IN BREAST TUMORS
Authors: Cyganov M. M. , Ibragimova M. K. , Hozyainova A. A.
Published: February 2023

It has been shown that the loss of PALB2 function, due to mutations or chromosomal
aberrations, may have an impact on the effectiveness of chemotherapy treatment and disease
prognosis in patients with various oncological diseases. Thus, the aim of this work was to
evaluate the predictive and prognostic potential of DNA copy number aberrations and PALB2
gene mutations in breast tumors.
Materials and methods. The study included 66 patients with breast cancer (BC). To
evaluate the presence of DNA copy number aberrations (CNA), microarray analysis was
used with the CytoScanTMHD Array high density microarrays. Gene mutations were
assessed by sequencing on the MiSeq™ Sequencing System using the Accel-Amplicon
BRCA1, BRCA2, and PALB2 Panel. Results. The presence of the PALB2 CNA gene is not
associated with the effectiveness of neoadjuvant chemotherapy (NAC), p=0.07. The
presence of a deletion is determined by 100% metastatic-free survival, versus 68% in the
group with normal copy number (log-rank test p=0.04). It has been established that
elimination of the frameshift deletion c.2552delA mutation during NAC leads to an
objective response to treatment. Identified missense mutations (c.2993G>A; c.2014G>C;
c.1010T>C) were observed in patients with tumor progression. But only c.1010T>C has
pathogenic significance. The presence of mutations in the PALB2 gene is not associated
with metastatic survival (log-rank test p=0.15). Conclusion. Currently, there is little data on
the impact of disorders in the PALB2 gene on the effectiveness of treatment and prognosis
of the disease, but the study of this gene has great potential for testing focused on diagnosis,
prevention, and a personalized approach to the treatment of cancer patients
MECHANISMS OF ESCAPE FROM REPLICATIVE SENESCENCE OF TUMOUR CELLS AFTER EXPOSURE TO CHEMOTHERAPY
Authors: Cydenova I. A. , Cyganov M. M. , Ibragimova M. K. , Nushtaeva A. A. , Litvyakov N. V.
Published: February 2023

In 25% of patients with breast cancer, tumor cells after neoadjuvant chemotherapy (NAHT)
leave the state of replicative aging and form macrometastases. In patients with breast cancer, it was
shown that the exit from replicative aging with metastasis is observed only in those patients in
whose tumor WNT signaling is ectopically activated due to amplification of activator genes and
deletions of negative regulators of this signaling pathway.
Purpose: in a direct experiment on cell cultures differing in ectopic activation of WNT
signaling due to CNA (Copy Number Aberration) WNT signaling genes, to study the ability of
tumor cells to exit replicative senescence after exposure to chemotherapy drugs.
PROSPECTS FOR THE USE OF CHOKEBERRY IN FUNCTIONAL NUTRITION
Authors: Chagarova M. I. , Izgarysheva Natalia V
Published: February 2023

Purpose: To describe the advantages and disadvantages of mountain ash as a component
of functional nutrition.
INFLUENCE OF CHLORAMPHENICOL ON THE QUALITY OF FERROUS MILK PRODUCTS
Authors: Chaplygina Olga , Vesnina Anna , Prosekov Alexander
Published: February 2023

Antibiotics have a significant impact on the physicochemical, organoleptic and
microbiological characteristics of milk. It is known that the presence of an antibiotic in raw milk
also affects the technological parameters of the production of fermented milk products. This work is
aimed at studying the effect of chloramphenicol contained in milk on the quality of fermented milk
products.
CONTRIBUTION OF GENETIC PREDICTORS TO FORMATION OF HEALTH DEFICIENCY IN THE SEPARATE PERIOD AFTER CARDIAC SURGERY TREATMENT OF CONGENITAL HEART DEFECTS
Authors: Shabaldin A. V. , Igisheva L.N. , Rumyanceva A. A.
Published: February 2023

Objective: To study the contribution of xenobiotic biotransformation enzyme genes,
transcription factors, inflammatory and immune response receptors in determining health deficiency
in the separated period after cardiac surgery for congenital heart disease.
Materials and methods. 116 children who underwent radical correction of CHD were
examined. An assessment of the catamnesis of these children and genetic typing of genes encoding
enzymes for the biotransformation of xeno- and endobiotics (GSTP, CYP1A2, CYP1A1), involved
in the determination of cardiogenesis and processes in cardiomyocytes (CRELD-1, GATA-6,
NOTCH-1), innate ( TREM-1) and adaptive (HLA-DR) immunity. The search for predictors of
functioning deficit by physical, psycho-emotional, social, mental types was carried out using
multiple logistic regression.
Results. The level of functioning of various components of health one year after surgical
treatment was associated with the same factors. These factors negatively affecting the health of
children one year after heart surgery were: unfavorable living conditions, as well as genetic
predictor markers HLA-DRB1*07 and Creld1 T/C (rs9878047)*T.
INNOVATIVE TECHNOLOGIES IN THE PRODUCTION OF GOUDA-TYPE CHEESES
Authors: Shrayner V. A. , Kuular Ch.G.
Published: February 2023

Objective: to consider the issues of a special group of protein, easily digestible dairy
products - cheeses, according to their nutritional and biological value, production technology on the
example of Gouda cheese. To study the features of technology and the main stages of the
production process, with consideration of the technological scheme of mechanized production of
Gouda cheese.
CONTRIBUTION OF INHERITED VARIANTS OF THE FTO (RS9939609) AND ADRB3 (RS4994) GENES TO THE RISK OF OBESITY DEVELOPMENT AMONG KUZBASS RESIDENTS
Authors: Yakovleva A. A. , Soboleva O. A. , Torgunakova A. V. , Ponasenko A.V.
Published: February 2023

Objective: To study and compare the associations of FTO (rs9939609), ADRB3 (rs4994)
gene polymorphisms with obesity in sick and healthy Kuzbass residents.
The data of 1149 people (568 control and 581 main group) were used in this work. After
statistical processing of the data, it was found that rs9939609 of FTO gene increases the risk of
obesity in both healthy and atherosclerosis patients. No statistically significant associations were
found in the ADRB3 gene.
COGNITIVE IMPAIRMENT IN SOMATIC DISEASES: ETIOPATHOGENESIS, DIAGNOSTIC METHODS AND POSSIBILITIES OF PSYCHOLOGICAL CORRECTION
Authors: Yanickiy Mihail , Soloduhin A.V. , Seryy Andrey
Published: February 2023

The general clinical and psychological characteristics of cognitive disorders in somatic diseases
are given. Groups of such disorders are distinguished depending on their etiology. Methods of diagnosis
of cognitive disorders are characterized and psychological methods of their correction are substantiated.
TECHNOLOGICAL ASPECTS OF PRODUCTION AND ASSORTMENT OF LACTOSE-FREE DAIRY PRODUCTS
Authors: Verner A.V. , Chugunova O.V.
Published: February 2023

The features of technologies for the production of lactose-free and low-lactose dairy products, which provide for special operations for the hydrolysis of lactose or its removal using ultra- or nanofiltration followed by hydrolysis of the residual amount, are considered. The range of dairy products produced using these technologies in Russia at leading enterprises in this field of production is presented.
STUDY OF THE FERTATION OF DAIRY FOOD SYSTEMS FOR THE PRODUCTION OF A COTTAGE PRODUCT
Authors: Gavrilova Natalya , Ivanova N. F. , Konovalov S. A. , Chernopolskaya Natalya
Published: February 2023

The article presents a scientific substantiation of the relevance of the direction of research on the development of biotechnology of a paste-like curd product enriched with functional ingredients. The results of studies of the fermentation of dairy food systems enriched with various types of milk-protein concentrates are presented.
THE EFFECT OF DEFROSTING CONDITIONS ON THE QUALITY OF BLUE HONEYSUCKLE JUICE
Authors: Gora Natalia , Petrova A. A. , Belyaeva Oksana , Habarova M. E.
Published: February 2023

Objective: to evaluate the defrosting conditions effect of blue honeysuckle berries on juice yield and its physicochemical characteristics.
MAIN APPROACHES TO THE DEVELOPMENT OF A MEAT PRODUCT OF HERODIETIC NUTRITION
Authors: Gurinovich Galina , Il'inyh I. V.
Published: February 2023

The work is aimed at substantiating the formulation of minced meat semi-finished products for herodietic nutrition with a high content of calcium and ingredients designed to increase its bioavailability.
ANTIOXIDANT ACTIVITY OF BEE HONEY AND PROPOLIS IN MEAT SYSTEMS
Authors: Gurinovich Galina , Soldatova S. S.
Published: February 2023

The aim of the research was to study the antioxidant activity of bee honey and propolis in the process of lipid oxidation. The studies were carried out on model systems using methods that allow estimating the intensity of formation of primary and secondary oxidation products. In the first case, an initiated oxidation process was used, in the second – a method based on the interaction of secondary oxidation products with thiobarbituric acid. The high activity of propolis to inhibit the formation of hydroperoxides and malonic aldehyde has been established.
DEVELOPMENT OF DIABETIC MACULAR EDEMA IN PREGNANT PATIENTS WITH TYPE 1 DIABETES MELLITUS: DEVELOPMENT RISKS AND TREATMENT METHODS
Authors: Gusakov M. V. , Evstratova K. D. , Gorbunova D. R.
Published: February 2023

To identify the factors that contribute to the progression of DMO in pregnant women with DM1 and discuss methods for correcting this complication.
MECHANISMS OF DEDIFFERENTIATION OF NON-LIGHT BREAST CANCER CELLS TO STEM CELLS
Authors: Dolgasheva D.S. , Zdereva E.A. , Cydenova I.A. , Gaptulbarova K.A. , Ibragimova M.K. , Litvyakov N.V.
Published: February 2023

It is known that the ability to dedifferentiate in non-stem cells causes its malignancy and its ability to metastasize [1]. The lack of a tendency to dedifferentiate and detect the affected stem phenotype explains the inability to metastasize within one localization. Previously, we found that the acquisition of the ability to dedifferentiate is a marker of tumor growth to metastasis. This process occurs during ectopic expression of stemness genes due to amplification of their loci in different chromosomes of tumor cells. For the presence of clinical material, it was found that even more amplifications of two chromosomes in the residual rise is associated with a high frequency of metastasis [2]. Thus, the result of the work was the observation of the regulation of the regulation of dedifferentiation of tumor non-stem cells in tumor stem cells in in vitro models.
THE VALUE OF THE MASS FRACTION OF MILK FAT IN CHEESE PRODUCTION
Authors: Kalugina O. I.
Published: February 2023

Fat is the main component of most types of cheese. Differences in fat content between cheese groups depend on a number of factors, including the composition of milk, in particular, the ratio of protein and fat, and variations in cheese production processes that control the levels of milk fat and moisture retained in the cheese mass. The ratio of protein and fat in raw milk is the main factor affecting the fat content in cheese, as it determines the relative proportions of protein, fat, water. The aim of the work is to find out what importance the mass fraction of fat of raw milk has in the production of cheese.
CHEESE AS PREVENTION OF PROTEIN-ENERGY INSUFFICIENCY
Authors: Kalugina O. I. , Shlyapina K. A. , Baranova E.R. , Simon S. A.
Published: February 2023

Protein-energy depletion (PEW) is the depletion of protein/energy reserves observed in the most advanced stages of chronic kidney disease (CKD). PEW is widespread among patients on chronic dialysis and is associated with adverse clinical outcomes, high morbidity/mortality rates and increased healthcare costs. Cheeses are characterized by a significant content of proteins, milk fat, as well as minerals. Cheese proteins are better absorbed in the human body, compared with dairy. Extractive elements of cheeses have a positive effect on the digestive glands, increase appetite. The nutrients contained in cheese are absorbed by the body almost completely.
RESEARCH AND DEVELOPMENT OF PROTEIN HYDROLYZATE TECHNOLOGY AS A BASIS FOR THE PRODUCTION OF PROTEIN SHAKES
Authors: Katyuhina T. O. , Poturaeva Natalia , Milentyeva Irina , Fedorova Anastasiya
Published: February 2023

Purpose: research and development of protein hydrolyzate technology as a basis for the production of protein shakes
THE USE OF BRINE IN THE PRODUCTION OF RYE MALT
Authors: Kiseleva Tatyana , Yaroslavceva A. V.
Published: February 2023

The paper considers the possibility of using concentrated mineral salts of the Karachi spring to regulate the process of growth and accumulation of enzymes in the production of malt from rye.
STUDY OF THE FOAMING PROPERTIES OF AQUAFABA
Authors: Klimenko A. A. , Barsukova N. V.
Published: February 2023

The use of vegetable raw materials as an alternative to animal products is one of the key trends in modern society. At the same time, it is important to take into account not only the nutritional value of the components of the recipe, but also the technological properties of alternative components. Bean products have foaming properties similar to those of a chicken egg. An urgent task is to study these properties for the production of specialized confectionery products. This article presents an analysis of the foaming characteristics of freeze-dried decoctions of industrial legumes and homemade chickpea decoctions.
APPLICATION OF DIETARY FIBER IN ENRICHMENT OF MEAT PRODUCTS
Authors: Kolbina Anastasia , Ryazanov S. C. , Shestak I. A.
Published: February 2023

Purpose: consideration of up-to-date information on the use of dietary fibers in the formulations of fortified meat products, as well as their influence on the technological properties of meat
THE RELEVANCE OF THE APPEARANCE OF A VEGETABLE ANALOGUE OF MEAT
Authors: Kolbina Anastasia , Ryazanov S. C. , Shestak I. A.
Published: February 2023

Purpose: evaluate the prospects for the production of vegetable analogs of meat, study the history of creation and the need for their development.
USE OF MILK PROTEIN CONCENTRATE IN CHEESE TECHNOLOGY WITH A HIGH SECOND HEATING TEMPERATURE
Authors: Kopaneva N. B. , Gavrilova Natalya , Chernopolskaya Natalya
Published: February 2023

The purpose of this study is to study the effect of Milkmix Universal milk protein concentrate, produced in St. Petersburg, Russia, on the technological parameters of raw milk, improve the technology of cheese with a high temperature of the second heating, and develop the main technological parameters of its production
THE USE OF VEGETABLE RAW MATERIALS IN THE TECHNOLOGY OF BAKERY PRODUCTS
Authors: Kryukova E.V. , Kryukov A.V.
Published: February 2023

The article discusses the possibility of using a mixture of turmeric, barberry and fennel in the technology of bakery products. An organoleptic evaluation of baked bakery products was performed, as a result of which an optimal sample was selected with 18% replacement of premium wheat flour with an additive. The physicochemical parameters were determined, the shelf life of the developed bakery products was established.
JUSTIFICATION OF THE NORMS FOR THE USE OF FOOD ADDITIVES FOR CHICKEN MEAT PRODUCTS
Authors: Kudryashova O.A. , Myshalova O
Published: February 2023

The research is aimed at studying the functional and technological properties of the meat of broiler chickens of the Ross-308 cross and substantiating the use of sodium pyrophosphate and mineral concentrate from eggshells in the production of poultry products. Data on changes in pH and water-binding capacity in the post-slaughter period were obtained. It has been established that the meat of broiler chickens of the Ross-308 cross is suitable for industrial processing after 5-6 hours of autolysis. In the manufacture of products, instead of phosphates, an eggshell mineral concentrate can be used.
PRACTICAL ASPECTS OF THE DEVELOPMENT OF A BISCUIT FOR A CONFECTIONERY ROLL IN ORDER TO EXPAND THE RANGE OF SPECIALIZED FOOD PRODUCTS
Authors: Kurakin Mikhail , Nefedova E. V.
Published: February 2023

The paper presents the recipe and technology of making a biscuit for a confectionery roll with a reduced energy value.
THE USE OF CHITOSAN AND EXTRACTS OF BIOLOGICALLY ACTIVE SUBSTANCES IN THE TECHNOLOGY OF FERMENTED DAIRY PRODUCTS
Authors: Lodygin Aleksei , Evdokimov Ivan , Poklar Ul'rih N. , Halanskaya D. M.
Published: February 2023

The relevance of chitosan and biologically active substances plant extracts use of in the
technology of fermented dairy products for functional purposes is substantiated. The results of study
of Lbc. rhanmnosus culture microencapsulation process using chitosan as a carrier are presented.
The doses of milk thistle and peppermint extracts based on cheese whey in skim milk during the
cultivation of probiotic cultures were justified.
PHYTOCHEMICAL COMPOSITION OF THE EXTRACT OF THE PLANT AMELANCHIER OVALIS, GROWING ON THE TERRITORY OF THE SIBERIAN FEDERAL DISTRICT
Authors: Loseva Anna , Dyshlyuk Lyubov , Drozdova Margarita , Milentyeva Irina
Published: February 2023

Antioxidants from plant raw materials are promising substances for suppressing excess free
radicals formed as a result of oxidative stress and contributing to the development of a number of
diseases. Objective: to study the phytochemical composition of Amelanchier ovalis. Gallic,
chlorogenic, protocatechic acids and their derivatives were found in the dry extract of Amelanchier
ovalis berries.
ON THE QUESTION OF THE CONTRIBUTION OF SOME CYTOKINES TO THE FORMATION AND DEVELOPMENT OF AUTOIMMUNE THYROID DISORDERS
Authors: Manikovskaya N. S.
Published: February 2023

Autoimmune thyroid disorders are considered common but understudied pathologies. The
review provides a brief analysis of current data on the role of some cytokines considered as potential
candidates for the risk of developing autoimmune diseases.
ASSESSMENT OF GENOME STABILITY IN WORKERS OF THE COAL-BORNE THERMAL POWER PLANTS OF KUZBASS WITH MICRONUCLEAR TEST IN BLOOD LYMPHOCYTES
Authors: Maruschak A. V. , Eliseykin A. M. , Zaushintsena Alexandra
Published: February 2023

Objective: to study the cytotoxic effects in workers of coal-fired thermal power plants.
The paper analyzes the cytogenetic and proliferative parameters of blood cells in 50
employees of thermal power plants and state district power plants and 50 non-working residents of
the Kemerovo region. Data have been obtained on the cytotoxic compound of compounds present in
the environment of industrial enterprises at the plant of working coal-fired thermal power plants.
TRAINING OF NEW GENERATION SPECIALISTS FOR THE FIELD OF NUTRITION
Authors: Mayurnikova Larisa , Zinchuk S. F.
Published: February 2023

It is shown that the transition to a new level of development of society requires a new
paradigm of education and the process of training specialists in the field of nutrition, ensuring food
security. For the effectiveness of the process of training a new generation of specialists, creativity
should be the basis of training, as an element of project activity and innovative development of the
industry.
PHYTOCHEMICAL STUDY OF CALLUNA VULGARIS
Authors: Babich O.O. , Larina V.V. , Skrypnik L.N.
Published: February 2023

This work investigated the antioxidant and antimicrobial activity, as well as the
metabolomic composition of various extracts of C. vulgaris. The dependence of the properties
and compositions of extracts on the extraction parameters is shown. The work allows to
conclude about the prospect of using C. vulgaris as a source of active components with
antioxidant and bactericidal properties.
IMPROVEMENT OF KVASS TECHNOLOGY THROUGH THE USE OF DRY YEAST
Authors: Miller Yuliya , Kiseleva Tatyana
Published: February 2023

The possibility of using dry brewer's yeast «Saflager S-23» and «Saflager W-34/70» in the
production of kvass is shown. The technological parameters of the fermentation stage are proposed.
The quality indicators of kvass have been determined.
PROSPECTS FOR THE DEVELOPMENT OF NEW FUNCTIONAL FOOD PRODUCTS WITH IMMUNO-CORRECTING PROPERTIES
Authors: Neverov V. Yu. , Trigub V. V.
Published: February 2023

Objective: development of an original formulation of a non-alcoholic balm as a functional
product based on plant raw materials from the Tyumen region with immunomodulating, tonic
properties to increase the body's resistance to adverse climatic conditions of the environment.
SIMULATION OF BAKERY PRODUCTS WITH " REISHI" MUSHROOM POWDER
Authors: Novoselov Sergey , Dubrovskaya A. V. , Isaeva N. V.
Published: February 2023

The relevance of the development of bakery products with the addition of "Reishi"
mushroom powder is considered. The properties of the mushroom "Reishi" and its practical
application are described. The rationale for the development of food products in the form of bakery
products with the addition of "Reishi" mushroom powder is presented.
BAKERY PRODUCTS WITH THE ADDITION OF MUSHROOM POWDER "GRIFOLA CURLY" FOR THERAPEUTIC AND PROPHYLACTIC USE
Authors: Novoselov Sergey , Plotnikova A. A. , Isaeva N. V.
Published: February 2023

The relevance of the development of bakery products is determined, taking into account
the therapeutic and prophylactic purpose with the addition of mushroom powder "Grifola
curly". The properties of the mushroom "Grifola curly" and its practical application are
described.
CHARACTERISTICS OF THE KUZBASS COAL INDUSTRY WORKERS CATERING ORGANIZATION
Authors: Ovrova I. B. , Varlamova S. Yu. , Krapiva Tatyana , Davydenko Nataliia
Published: February 2023

The paper describes the organization of catering for workers in the coal industry on the example of JSC
HC "SDS-Coal". The purpose of the work is to determine the role of catering at the enterprise in the
prevention of occupational diseases. The presence of preventive measures at the enterprise aimed at
reducing morbidity is shown.
DEEP BILATERAL NEUROSTIMULATION (DBS GPI) AS AN EFFECTIVE METHOD OF TREATMENT OF LEVODOPA INDUCED DOSE PEAK DYSKINESIA IN PARKINSON'S DISEASE. CASE REVIEW
Authors: Oleynikova D. I.
Published: February 2023

Objective: Purpose: To study scientific publications on this issue; to study the medical
history of the patient with the implantation of the DBS GPi deep brain stimulation system from 2
sides; to study the indications, methodology, immediate and long-term results of this neurosurgical
intervention, to evaluate the effectiveness of this surgical intervention in a particular patient
BIOCHEMICAL PARAMETERS OF BLOOD IN PREGNANT WOMEN NORMALLY AND WITH CHROMOSOMAL PATHOLOGY OF THE FETUS
Authors: Rytenkova O. I. , Volkov A. N.
Published: February 2023

As part of the prenatal screening of the first trimester of pregnancy, biochemical parameters of
blood were analyzed in 1214 women. The level of serum markers β-hCG and PAPP-A in pregnant
women are sensitive indicators of chromosomal pathology of the fetus. With trisomy on the 21st
chromosome, an increase in the content of β-hCG and a decrease in the level of PAPP-A are often
observed in the patient's blood. With fetal trisomy on chromosome 18, both indicators show a
tendency to a significant decrease relative to the norm. It should be taken in account that both with
fetal euploidy and with chromosomal abnormalities, atypical values of indicators can be established,
which requires the involvement of additional markers in the analysis. In any case, biochemical
analysis allows only to establish the likelihood of the presence of pathology of the fetus and attribute
pregnancy to the risk group. The final conclusion about the presence or absence of chromosomal
pathology can only be given by a cytogenetic analysis of the fetal material.