bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Weight Change and Physical Activity with Knee Pain and Health-Related Quality of Life in East Asian Women Aged 50 Years and Older with Knee Osteoarthritis: A Population-Based Study
Authors: Chang Chong Bum , Choi Young , Kang Seung Baik , Chung Chin Youb , Park Moon Seok , Lee Kyoung Min
Published: January 2022

Objectives This study aimed to investigate the association of self-reported weight change and physical activity with the level of knee pain and health-related quality of life in East Asian women with knee osteoarthritis using population-based data. Methods A total of 564 women (mean age, 68.2 years, standard deviation, 8.9 years) aged 50 years or older with knee osteoarthritis (Kellgren-Lawrence (K-L) grade ≥ 2) were included in the data analyses from the fifth Korea National Health and Nutrition Examination Survey. Data regarding the radiographic grade, self-reported weight change during the past year, physical activity, level of knee pain, and health-related quality of life (EuroQOL five-dimension (EQ-5D) index) were collected. Multiple regression analysis was performed to identify factors significantly associated with the level of knee pain and health-related quality of life in subgroups according to the body mass index (BMI) range (≤ 22.5, between 22.6 and 27.5, and > 27.5 kg/m2). Results In the whole group, the level of knee pain was significantly associated with K-L grade ( P < 0.001), and EQ-5D was negatively associated with age ( P < 0.001), the level of knee pain ( P < 0.001), and weekly hours of vigorous-intensity activity ( P = 0.026). In the subgroup analysis, weight gain showed significant association with the level of knee pain only in women with 22.5 kg/m2 < BMI ≤ 27.5 kg/m2 ( P = 0.006). Weight gain showed significant association with EQ-5D in women with BMI ≤ 22.5 kg/m2 ( P = 0.047) whereas weekly hours of moderate-intensity activity was negatively associated with EQ-5D in women with BMI > 27.5 kg/m2. Conclusions The association of weight change and physical activity with knee pain and health-related quality of life might be different according to BMI ranges. Well-designed interventions to improve both knee pain and health-related quality of life need to be investigated in future studies that would strictly control physical activity, diet, and weight changes.
The Importance of Lamina Size Measurement and Proper Implants Selection before Laminoplasty : Two Case Reports
Authors: Kim Dong Hwan , Lee Su Hun , Kim Dong Ha , Nam Kyoung Hyup , Han In Ho , Choi Byung Kwan
Published: January 2022

Open door laminoplasty using plates is a safe and effective procedure for multi-level cord compression. To achieve stable laminar arch, various types of plate have been developed and used. Now, we introduce two rare complications related to the laminar shelf of plate.

In the first case, we used the wider laminar shelf plate because the elevated lamina did not fit well into the usual laminar shelf. During follow-up, cord compression due to laminar shelf was observed.

And in the second case, the laminar shelf of plate did not fit into the elevated lamina, so we inserted it with a little bit of force. But the patient’s symptom was not improved. On CT image, the inner cortical bone of the lamina was fractured.

To prevent these complications, surgeons need to consider the thickness of the lamina and the size of the laminar shelf before surgery.
Flow Diverter Device for Treatment of Cerebral Aneurysm with Short-Term Follow Up: Two Case Reports
Authors: Park Jung Hyun
Published: January 2022

The flow diverter device (FDD) is an important treatment method for cerebral aneurysms, especially for intracranial dissecting aneurysms. This paper is the result of FDD treatment for two cases of vertebral dissecting aneurysm (VADA) patients and short-term follow-up at 3 months. All two cases were targeted for unruptured cerebral aneurysm, and 4-vessel angiography was performed as a follow-up examination for 3 months after receiving the procedure. As result, it was possible to shorten the period of use of antiplatelet drugs.

In the case of VADA, there are limitations in general coiling procedures or conventional surgical treatment methods. In that sense, the FDD treatment method can be a very effective alternative treatment of VADA
A Ruptured Vertebral Artery Dissecting Aneurysm that Grew Immediately: Case Report
Authors: Park Jung Hyun
Published: January 2022

The etiology of the vertebral artery dissecting aneurysm (VADA) is unknown and they frequently occur in relatively healthy young men. Therefore, the pathological mechanism by which VADAs occur has not been accurately identified. In this paper, we will examine a case in which a young man complaining of a simple headache became unconscious due to the rupture of a VADA in grew immediately.
De l’histoire et de l’avenir de la formation des maîtres au Canada anglais
Authors: Boote David N. , Wideen Marvin F. , Mayer-Smith Jolie , Yazon Jessamyn O.
Published: January 2022

Au Canada, la formation des enseignants traverse une période riche en réformes. Toutefois, la plupart de ces efforts piétinent complètement ou n’ont qu’un faible impact. Nous soutenons ici que cette situation découle d’une absence de perspectives historiques. Nous analysons l’histoire de la formation des enseignants au Canada anglais, en montrant comment les diverses institutions de formation des enseignants qui se sont succédé se sont systématiquement approprié le pouvoir social d’autorités traditionnelles. Cette analyse sociale de la tradition oriente notre attention sur les interrelations entre les institutions, les rôles sociaux, le pouvoir et les connaissances. En explorant ces interrelations, nous montrons comment les formateurs d’enseignants, sur le plan individuel et collectif, et les forces historiques sociales plus élargies entrent en complicité pour maintenir le statu quo. Nous concluons en avançant que les formateurs d’enseignants ne peuvent devenir des agents de changement social plus efficaces qu’en réexaminant la manière dont ils se situent au plan socio-historique et en articulant de manière discursive la nouvelle autorité basée sur l’habileté plutôt qu’en récapitulant de manière compulsive les structures traditionnelles de pouvoir.
Imaginaires du tout-inclus et autres lieux d’enclavement volontaire
Authors: Parenteau Olivier
Published: January 2022

Le présent dossier invite à franchir les seuils de divers lieux d’enclavement volontaire. Qu’ils soient représentés dans des oeuvres littéraires, des films, des téléséries, voire même des émissions de téléréalité, ces parcs manifestent toujours un caractère d’irréalité qui renforce leur isolement par rapport au monde extérieur : ils ouvrent un espace-temps qui leur est propre.
De machine fictionnelle à machine de guerre. Général Instin
Authors: Savard Valérie
Published: January 2022

Dans Général Instin, projet collectif instauré par Patrick Chatelier en 1997 suite à la découverte du monument funéraire du général Adolphe Hinstin, le personnage historique devient un « personnage-entité », une présence absente vectrice de fiction. Cet article vise à montrer que le Général Instin est une machine fictionnelle proliférante et rhizomatique qui présente plusieurs caractéristiques de ce que Deleuze et Guattari nomment une « machine de guerre ».
Développer des connaissances lexicales et grammaticales sans support écrit et sans production grâce à une approche par tâches basée sur la compréhension
Authors: Beaulieu Suzie , Fortier Véronique , Damiens Julie , Laberge Carl , Fillion Catherine
Published: January 2022

Dans cet article, nous traitons de l’approche par tâches basée sur la compréhension, un type d’approche qui favorise le développement langagier, notamment du lexique et de la grammaire, en passant essentiellement par la compréhension orale. Selon les études antérieures, menées auprès d’enfants (Shintani, 2012, 2016) et d’adolescents (Erlam et Ellis, 2018, 2019) débutant leur apprentissage d’une langue seconde, l’utilisation de cette approche favoriserait le développement de connaissances lexicales et grammaticales chez les participants des groupes expérimentaux, et ce, davantage que chez les apprenants des groupes témoins qui devaient produire les éléments lexicaux et linguistiques ciblés. Considérant le potentiel de cette approche et le fait qu’elle diffère de nombreuses autres où l’écrit et la production occupent une place importante, elle nous semblait également adaptée pour des apprenants adultes peu scolarisés ou peu alphabétisés, dont la littératie est émergente. Afin d’évaluer la mise en place d’une approche basée sur la compréhension auprès de cette population, nous avons développé un partenariat avec un centre de formation des adultes de la région de Québec. Nous présentons une des séquences développées de concert avec une enseignante du centre. La séquence vise le développement du vocabulaire de l’habitation, des marques de singulier et pluriel et des prépositions de lieu. Afin de rendre compte de l’ensemble du processus de développement et d’implantation de la séquence, nous présentons les points de vue de l’enseignante, des participants et de l’équipe de recherche à cet effet.
Comment les techniques théâtrales aident les apprenants de FLS à interagir pour compléter des tâches de communication orale
Authors: Thibault Laurence
Published: January 2022

En didactique des langues, la perspective actionnelle reconnait l’apprenant comme un acteur social dans le sens où celui-ci complète des tâches qui l’amènent à interagir avec des interlocuteurs natifs et non natifs (Conseil de l’Europe, 2001). Le présent article examine comment les techniques théâtrales en français langue seconde (FLS) facilitent les interactions dans la communauté d’apprentissage, en classe, et la communauté locale, hors classe. L’article offre une réflexion de pratique d’enseignement du FLS en contexte universitaire au Canada, plus précisément dans le cadre d’un cours de communication orale où le projet principal d’apprentissage, appelé reportage, comprend des tâches comme l’entrevue et la présentation magistrale. Ces dernières sont réalisées en partie grâce au travail corporel et aux jeux dramatiques constitutifs du cours de langue.
Between Lines and Beyond Boundaries: Alootook Ipellie’s Entanglements of Space
Authors: Desrochers-Turgeon Émélie
Published: January 2022

Manifold representations of the dwelling are expressed in the work of artist, poet, writer, editor, and activist Alootook Ipellie in the bi-monthly publicationInuit Todayin the 1970s and 1980s, as a cross-section through key moments in Inuit Nunangat history. This essay thus examines Ipellie’s representations of space—not as an attempt to theorize Inuit space but rather to offer reflections on how these representations challenged ways of knowing and interpreting Arctic communities. We first address the Arctic representation in Ipellie’s work, which emphasizes the existing richness of the land according to Inuit perspectives as opposed to Qallunaat (non-Inuit) interpretations. His drawings also offer political comments on land disputes and the exploitation of territory. We then explore the representation of buildings, as Ipellie witnessed the transition from traditional to government housing. Ipellie’s humour-based approach constituted a strong social and political critique of housing issues and settler-colonial building practices. This artist acknowledged Inuit ingenuity when speaking of traditional housing, thus advocating for Inuit knowledge, invention, and built heritage. Lastly, we discuss the representation of multiple voices in the struggles over space, including Inuit communities and non-human agents, such as animals and land. Dwelling on the notion of “lines” and “the in-between”, we consider the thickness of Ipellie’s drawn lines and attend to the multiple entanglements between the artist’s political cartoons and the many lines of settler-colonialism, such as boundaries, frontiers, roads, pipelines, spatial construction, buildings, and planning.
Habiter le Nunavik : Considérer le système de production du logement en envisageant la complexité
Authors: Vachon Marika
Published: January 2022

Cet article présente une réflexion sur les systèmes actuels de production du logement au Nunavik, au nord du Québec, à la lumière desthéories de la complexitéet de laperspective de l’habiter. L’analyse de la littérature démontre différentes formes de complexité dans le système ; les processus actuels relatifs à la construction des logements au Nord sont toujours le reflet d’une perspective centrée sur le fait « de construire » et sur un modèle de rationalité technique, plutôt que sur une perspective considérant le fait « d’habiter » le Nord, intégrant les considérations sociales, culturelles et symboliques. L’article explore les caractéristiques propres à l’habiter inuit et les associe à la perspective de l’habiter d’Ingold (2000). À travers l’engagement dans l’action, la perspective de l’habiter se conjugue aux méthodes ouvertes proposées par les approches de la complexité, afin de proposer des pistes pour un logement nordique plus durable, mieux ancrées dans les réalités, les aspirations et les façons d’habiter des communautés inuit.
Les droits ancestraux des peuples autochtones n’ayant pas signé la Convention de la
Baie-James : la thèse de l’extinction unilatérale à l’épreuve des droits
fondamentaux
Authors: Otis Ghislain
Published: January 2022

Certains peuples autochtones du Québec revendiquent des droits ancestraux sur
le territoire visé par la Convention de la Baie-James et du Nord québécois alors
qu’ils ne sont pas signataires de cette dernière. Or, la loi adoptée par le Parlement du
Canada en 1977 pour donner effet à la Convention prétend éteindre les droits et les
revendications territoriaux de « tous les Indiens et de tous les Inuit » dans le territoire
« conventionné », et non seulement ceux des Cris et des Inuit qui sont parties à la
Convention. Dans cet article, l’auteur évalue la conformité de cette disposition extinctive
avec la Déclaration canadienne des droits. Il conclut qu’elle viole la Déclaration
en privant, de manière injustifiée, les membres des peuples non signataires du droit de ne
pas faire l’objet de discrimination raciale dans la jouissance de leur
bien.
Les enjeux juridictionnels de la future Agence canadienne de l’eau
Authors: Fortin Marie-France , Lillo Alexandre
Published: January 2022

Le gouvernement fédéral propose de créer une Agence canadienne de l’eau. Le processus, amorcé en 2020, devrait s’étaler sur plusieurs mois. Dans le cadre des consultations publiques menées en début d’année 2021, Environnement et Changement climatique Canada a récemment publié un document de discussion intitulé « Vers la création de l’Agence canadienne de l’eau ». Les premiers éléments révélés demeurent à la fois larges et généraux. Les nombreuses possibilités proposées ratissent large et les formulations choisies manquent parfois cruellement de précision. Malgré tout, ce document se présente comme une occasion unique de faire état du contexte juridique de l’eau au Canada, en particulier des considérations intergouvernementales qui pourraient s’avérer au coeur de la constitution de cette structure. Plus encore, la généralité du document de discussion permet d’explorer les scénarios juridiques éventuels de la future Agence canadienne de l’eau, ainsi que leurs possibles assises juridictionnelles.
De la mobilisation du consociationalisme par le droit
Authors: Mathieu Félix , Guénette Dave
Published: January 2022

Le consociationalisme est un modèle théorique et normatif de gestion du pluralisme qui cherche à favoriser des schèmes de gouvernance démocratique et de cohabitation pacifique dans des sociétés plurielles ou fragmentées. Sur le plan théorique, on peut résumer la logique générale du consociationalisme en mettant de l’avant quatre principes fondamentaux : un gouvernement de coalition, la représentation proportionnelle, le droit de veto et l’autonomie segmentale. Or, ces principes normatifs sont relativement abstraits et se prêtent à de nombreuses interprétations de la part des acteurs politiques. À ce titre, comment les sociétés fragmentées parviennent-elles à incorporer le consociationalisme et ses principes à leur système juridique? Cet article vise à apporter des éléments de réponse à ce questionnement, en comparant trois démocraties libérales et consociatives occidentales : la Belgique, l’Irlande du Nord (Royaume-Uni) et le Tyrol du Sud (Italie). Notre objectif est donc, d’une part, de mieux comprendre le contexte dans lequel les acteurs politiques de ces trois sociétés fragmentées ont entrepris d’introduire des mécanismes de partage du pouvoir, et, d’autre part, d’être en mesure de saisir comment le consociationalisme a pu y être mobilisé par le droit.
Évolution de l’identité francophone au Manitoba (1738-2017)
Authors: Blay Jacqueline
Published: January 2022

Forgée par la vision du chef métis, Louis Riel, la province du Manitoba a une place unique dans la Confédération canadienne, et ce, grâce à la nation métisse, aux voyageurs originaires du Bas-Canada et aux colons écossais venus s’établir à la colonie de la Rivière-Rouge. Le Manitoba devenue province, les partenaires métis et Canadiens français de la colonie, malgré leur rôle fondamental, ont vécu une histoire en dents de scie et vu leurs droits constitutionnels, territoriaux, linguistiques et scolaires abolis. Ayant vécu pendant des décennies en marge de la majorité manitobaine, ils ont retrouvé, il y a à peine une trentaine d’années, le plein rôle citoyen qui leur revenait après avoir relevé les défis posés par des gouvernements hostiles ou ignorants de la valeur de leur contribution.

Les décennies de discrimination suivies par les années de revendications ont façonné leur identité qui, par la force des événements, a dû s’adapter, à chaque période, pour devenir la francophonie manitobaine actuelle. Tout comme au XIXe siècle, cette francophonie fait face, aujourd'hui, à des enjeux identitaires uniques dans un contexte de coexistence avec la majorité anglophone. Affaiblie par les luttes juridiques, elle se relève et reprend de la vigueur en s’appuyant sur les acquis législatifs, juridiques et communautaires des 30 dernières années. Ces efforts sont néanmoins insuffisants puisque, tout comme le Canada, elle doit attirer des immigrants francophones pour combler ses déficits démographiques.

Cet article examine les circonstances dans lesquelles l’identité bien spécifique des francophones du Manitoba a évolué à partir de la dualité de la colonie de la Rivière-Rouge jusqu’à un pluralisme francophone sur lequel reposent leur avenir et leur épanouissement.
Médias et défense du patrimoine urbain francophone en milieu minoritaire au Manitoba : le cas du « 500 Taché » dans La Liberté
Authors: Robineau Anne
Published: January 2022

Cet article s’inscrit dans une perspective sociologique. Il vise à montrer comment les médias francophones manitobains participent aux discours sur la défense du patrimoine de la communauté franco-manitobaine. Les concepts d’identité et de patrimonialisation nous serviront à comprendre l’émergence d’un discours plus militant en faveur de la protection du patrimoine faisant référence à l’histoire de la culture francophone dans l’Ouest canadien. Nous nous interrogerons plus particulièrement sur la façon dont ce discours est relayé par le journal La Liberté en prenant l’exemple de la controverse du « 500 Taché ». Le but est de mesurer le rôle des médias dans leur façon de mobiliser les ressources nécessaires à la mise en valeur de la communauté qu’ils desservent. Cela conduira à distinguer la spécificité des médias francophones en milieu minoritaire qui, selon nous, consiste autant à informer qu’à cultiver le sentiment d’appartenance à une collectivité.
Naviguer son patrimoine : l’histoire de Roger Teillet
Authors: Teillet Philippe Martin
Published: January 2022

Cet article documente les moments marquants de la vie remarquable de l’honorable Roger Teillet (1912-2002). Descendant de Jean-Baptiste Lagimodière et Marie-Anne Gaboury et petit-neveu de Louis Riel, il a grandi à Saint-Vital, au Manitoba, dans un foyer, une communauté et une époque politiquement chargés. Il a volé en tant que navigateur de bombardiers pendant la Seconde Guerre mondiale et a été prisonnier de guerre au Stalag Luft III. Il a été élu à l’Assemblée législative du Manitoba et à la Chambre des communes à Ottawa où il a également été nommé ministre des Affaires des Anciens Combattants. Toujours conscient de son héritage pionnier et métis, c’était un homme fier qui a très bien servi sa communauté.
La experiencia migrante en las crónicas de Gabriela Wiener
Authors: Geremek Zuzanna , Kowalska Katarzyna
Published: January 2022

This article analyses a migrant’s experience – one that changes, and is fluid and dynamic – in the selected reportages by the Peruvian author Gabriela Wiener – El Gran Viaje, Teléfono malogrado conmigo misma and Del lado de acá y del lado de allá. Following the concept of the vagabond as coined by Zygmunt Bauman, we show how the migrant status of the narrator-protagonist changes. We argue that this process takes place at the level each of given space: Peru – fades away, and Barcelona, at first a hostile place, becomes the place where she manages to forge her identity as a writer. To illustrate this point, we make recourse to the theories of Henri Lefebvre, Michel Foucault and César Aira.
„Schriftstellerischer“ Kampf gegen antipolnische Stereotype? Thomas Manns Interview für La Pologne Littéraire
Authors: Skwara Tadeusz
Published: January 2022

In this article, an interview that Thomas Mann gave to the magazine La Pologne Littéraire in April 1927 is carefully analyzed in the context of Polish-German relations. At the time, the public opinion of the Weimar Republic was dominated by anti-Polish stereotypes. In the analyzed interview, Mann looks to show a different face of Poland, depicting it as a country with a rich cultural heritage that is insufficiently known in Germany. His fight against anti-Polish stereotypes would not yield any visible results but his article still remains an engaging testimony of Polish-German dialogue.
Endovascular occlusion of giant serpentine aneurysm: A case report and literature review
Authors: Civlan Serkan , Yakar Fatih , Coskun Mehmet Erdal , Sato Kenichi
Published: January 2022

Giant serpentine aneurysms (GSAs) are a rare subgroup of intracranial aneurysms. Separate inflow and outflow flow due to intraluminal thrombosis is the most distinguishing feature of GSAs. In treating these lesions, surgical clipping and ligation were the main treatments in the past, but bypass for revascularisation and endovascular therapies (EVTs) for deconstructive purposes are more prominent today. A 51-years-old male patient presented with headache and mild right hemiparesis. He had a GSA arising from the left fetal type posterior cerebral artery (fPCA) that was out of follow-up for six years. Radiological images revealed midline shifting and mesencephalon compression. We performed endovascular parent artery coil occlusion. The symptoms of the patient improved at the first-month follow-up. Even if there is a mass effect in GSAs, deconstructive EVT is a safe and feasible method for managing these lesions.
Experimental Evaluation of Prophylactic and Therapeutic Antioxidant Potential of Trimetazidine in Carbon Tetrachloride Induced Oxidative Stress in Rats
Authors: Mate Vijay Haribhau , Pandit Vijaya Anil , Padalkar Pradnya Hemant , More Chetan Shrirang , Khade Kapil S
Published: January 2022

Introduction: Exposure to various drugs and chemicals lead to oxidative stress. Carbon Tetrachloride (CCl4) produces rise in oxidative stress leading to hepatic damage. The drug Trimetazidine (TMZ) shows hepatoprotective activity but its mechanism is not known. The present study would help in establishing antioxidant activity of TMZ as probable mechanism. Aim: To evaluate the antioxidant potential of TMZ in CCl4 induced oxidative stress when given prophylactically/therapeutically in rats. Materials and Methods: An experimental animal study was conducted on 80 adult Wistar rats of either sex (weight-150 to 200 gm) from March 2010 to December 2010 in Bharati Vidyapeeth Medical College, Pune, Maharashtra, India. Randomly, all animals were grouped into 10 equal groups. Group i was normal control (received only water). To induce oxidative stress CCl4 (0.5 mL/kg/d i.p.) was given to all the animals of Group ii to Group x for seven days. The TMZ was given in two doses, TMZ1 (5 mg/kg orally for Group iii and vii) and TMZ2 (10 mg/kg orally for Group iv and viii). Positive standard control (Group v and Group ix) received Liv.52 (1 mL/kg orally). Group vi and Group x received combination of TMZ1 (5 mg/kg orally)+Liv.52 (1 mL/kg orally). Drug treatment was given to animals in group iii, iv, v and vi for 1-14 days (preventive group) and in group vii, viii, ix and x from day 8 to day 14 (therapeutic group). On 15th day, rats were sacrificed and dissected for collection of liver. Part of the livers was homogenised to assess oxidative stress marker enzymes Malondialdehyde (MDA), Superoxide Dismutase (SOD) spectrophotometrically. Statistical analysis was done with one- way Analysis of Variance (ANOVA) followed by post-hoc analysis (Dunnett’s test) using GraphPad Prism 5.0 software. Results: Trimetazidine (5 mg/kg and 10 mg/kg) significantly reduced MDA levels and increased SOD levels when compared with CCl4 treated group suggested antioxidant activity. Combined administration of Liv.52 and TMZ1 also reduced oxidative stress and increased antioxidant activity. Conclusion: Results of the present study suggested that increased oxidative stress was significantly attenuated by drug TMZ in dose dependant manner when compared with the CCl4 group. The antioxidant potential of prophylactic and therapeutic administration of TMZ was comparable. The increased antioxidant effect by Liv.52+TMZ1 combination was only due to the additive antioxidant effects of Liv.52 and TMZ or any other mechanism was involved, needs to be further evaluated.
Quantitative and Multiplex Detection of Extracellular Vesicle‐Derived MicroRNA via Rolling Circle Amplification within Encoded Hydrogel Microparticles
Authors: Al Sulaiman Dana , Juthani Nidhi , Doyle Patrick S.
Published: January 2022

Extracellular vesicle‐derived microRNA (EV‐miRNA) represent a promising cancer biomarker for disease diagnosis and monitoring. However, existing techniques to detect EV‐miRNA rely on complex, bias‐prone strategies, and preprocessing steps, making absolute quantification highly challenging. This work demonstrates the development and application of a method for quantitative and multiplex detection of EV‐miRNA, via rolling circle amplification within encoded hydrogel particles. By a one‐pot extracellular vesicle lysis and microRNA capture step, the bias and losses associated with standard RNA extraction techniques is avoided. The system offers a large dynamic range (3 orders of magnitude), ease of multiplexing, and a limit of detection down to 2.3 zmol (46 × 10−18 m), demonstrating its utility in clinical applications based on liquid biopsy tests. Furthermore, orthogonal measurements of EV concentrations coupled with the direct, absolute quantification of miRNA in biological samples results in quantitative measurements of miRNA copy numbers per volume sample, and per extracellular vesicle.
Enantioselective Cascade Annulation of α‐Amino‐ynones and Enals Enabled by Gold and Oxidative NHC Relay Catalysis
Authors: Jiang Jianfeng , Wang Xia , Liu Shengping , Zhang Sichen , Yang Binmiao , Zhao Yu , Lu Shenci
Published: January 2022

We report herein an unprecedented gold and oxidative NHC relay catalysis that enables highly enantioselective cascade annulation between readily available α‐amino‐ynones with enals. This method utilizes the in situ‐generated pyrrolin‐4‐ones as a novel and versatile synthon, which engage with α,β‐unsaturated acylazolium intermediates generated from enals by oxidative NHC catalysis to produce pyrrole‐fused lactones in high yield and excellent enantioselectivity. Synthetic utility of the lactone products is also demonstrated by facile conversion to densely functionalized pyrroles and pyrrolin‐4‐ones in high yields with excellent stereopurity.
Reach control problem for affine multi‐agent dynamic systems on simplices by affine feedback
Authors: Lv Dejing , Wu Mingze , Ge Bin
Published: January 2022

Aiming at the reach control problem for a multi‐agent system composed of affine coupling systems, an affine controller is proposed. Different from affine single‐agent systems, additional difficulties are faced for multi‐agent systems on the reach control because of the coupling between agents. In this paper, we use the compactness and convexity of the simplex to overcome the above difficulties, and propose a sufficient condition to solve the reach control problem for multi‐agent systems, which aims to detect an affine feedback control such that each agent in the system first leaves a given simplex through a prespecified facet rather than a certain restricted facet in a finite time. In addition, necessary conditions for the solvability of the problem are obtained. Finally, the validity of the results is verified by a three‐dimensional numerical example.
Highly Stable, Low Redox Potential Quinone for Aqueous Flow Batteries**
Authors: Wu Min , Bahari Meisam , Jing Yan , Amini Kiana , Fell Eric M. , George Thomas Y. , Gordon Roy G. , Aziz Michael J.
Published: January 2022

Aqueous organic redox flow batteries are promising candidates for large‐scale energy storage. However, the design of stable and inexpensive electrolytes is challenging. Here, we report a highly stable, low redox potential, and potentially inexpensive negolyte species, sodium 3,3′,3′′,3′′′‐((9,10‐anthraquinone‐2,6‐diyl)bis(azanetriyl))tetrakis(propane‐1‐sulfonate) (2,6‐N‐TSAQ), which is synthesized in a single step from inexpensive precursors. Pairing 2,6‐N‐TSAQ with potassium ferrocyanide at pH=14 yielded a battery with the highest open‐circuit voltage, 1.14 V, of any anthraquinone‐based cell with a capacity fade rate <10 %/yr. When 2,6‐N‐TSAQ was cycled at neutral pH, it exhibited two orders of magnitude higher capacity fade rate. The great difference in anthraquinone cycling stability at different pH is interpreted in terms of the thermodynamics of the anthrone formation reaction. This work shows the great potential of organic synthetic chemistry for the development of viable flow battery electrolytes and demonstrates the remarkable performance improvements achievable with an understanding of decomposition mechanisms.
The protective effect of electroacupuncture on the renal cortex of SHRs: A metabonomic analysis
Authors: Yang Kezhen , Lv Taotao , Wu Jiaojuan , Zhang Xudong , Xue Yanjun , Yu Pengcheng , Liu Qingguo
Published: January 2022

Hypertension affects multiple organs in the body during the development of the disease. The antihypertensive effect of acupuncture has been confirmed. How the protective effect of electroacupuncture on the renal cortex of the spontaneously hypertensive rat (SHR) is achieved has not yet been determined. The purpose of this study was to understand the impact of electroacupuncture on the blood pressure of SHRs and the impact on metabolites in the renal cortex, looking for potential differential metabolites and then proceeding to the next step of exploratory research. The experimental animals were divided into four groups: control group, model group, electroacupuncture group and losartan potassium group. Electroacupuncture on bilateral Taichong (LR3) and Zusanli (ST36) lasted for 3 weeks, and the renal cortex was collected for metabonomics research. UHPLC–MS was used to analyze the changes in the metabolic spectrum of renal cortex tissue. The results showed that electroacupuncture can significantly reduce the blood pressure of SHRs. A total of 12 metabolites changed significantly in the comparison between each group and the model group.The possible mechanism is that the primary bile acid biosynthesis, bile secretion, tryptophan metabolism and other metabolic pathways affect the renal cortex.
MOF‐Derived Potassiophilic CuO Nanoparticles on Carbon Fiber Cloth as Host for Stabilizing Potassium Metal Anode
Authors: Liu Shuang , Yang Yujie , Qian Yang , Chang Ge , Zhao Xin , Tang Qunli , Hu Aiping , Chen Xiaohua
Published: January 2022

Potassium (K) metal anodes suffer the main obstacle of uncontrollable dendrite growth. One of the best ways to overcome this challenge is to build a stable potassiophilic host. Herein, we designed a Metal‐Organic Frameworks (MOF)‐derived CuO nanoparticles on carbon fiber cloth (CC) as a high potassiophilic host to prestore molten potassium for dendrite‐free K metal anode. The three‐dimensional host has a relatively large surface area and excellent mechanical strength, which helps to lower the local current density as well as buffer the volume expansion during the plating/stripping of K. The highly potassiophilic CuO nanoparticles could provide abundant nucleation sites for K, thereby guiding uniform K deposition with a low nucleation overpotential and inhibits the growth of dendrites. The CC@CuO@K anode could cycle for 2000 h at a current of 0.5 mA cm−2, which exceeds K metal anodes mentioned in other reports. Last but not least, by using the composite K metal as the anode to assemble the full cell, highly boosted performance can be achieved. Our result provides a tempting method for realizing dendrite‐free K metal anodes in PIBs, and also provides an opportunity for the application of other MOF‐based materials in the field of high‐performance K metal anodes.
Automated text‐level semantic markers of Alzheimer's disease
Authors: Sanz Camila , Carrillo Facundo , Slachevsky Andrea , Forno Gonzalo , Gorno Tempini Maria Luisa , Villagra Roque , Ibáñez Agustín , Tagliazucchi Enzo , García Adolfo M.
Published: January 2022

Introduction

Automated speech analysis has emerged as a scalable, cost‐effective tool to identify persons with Alzheimer's disease dementia (ADD). Yet, most research is undermined by low interpretability and specificity.

Methods

Combining statistical and machine learning analyses of natural speech data, we aimed to discriminate ADD patients from healthy controls (HCs) based on automated measures of domains typically affected in ADD: semantic granularity (coarseness of concepts) and ongoing semantic variability (conceptual closeness of successive words). To test for specificity, we replicated the analyses on Parkinson's disease (PD) patients.

Results

Relative to controls, ADD (but not PD) patients exhibited significant differences in both measures. Also, these features robustly discriminated between ADD patients and HC, while yielding near‐chance classification between PD patients and HCs.

Discussion

Automated discourse‐level semantic analyses can reveal objective, interpretable, and specific markers of ADD, bridging well‐established neuropsychological targets with digital assessment tools.
Fine‐scale ecological and anthropogenic variables predict the habitat use and detectability of sloth bears in the Churia habitat of east Nepal
Authors: Pokharel Manoj , Subba Asmit , Rai Dipa , Bhandari Simrik , Ghimirey Yadav
Published: January 2022

Once widespread throughout the tropical forests of the Indian Subcontinent, the sloth bears have suffered a rapid range collapse and local extirpations in the recent decades. A significant portion of their current distribution range is situated outside of the protected areas (PAs). These unprotected sloth bear populations are under tremendous human pressures, but little is known about the patterns and determinants of their occurrence in most of these regions. The situation is more prevalent in Nepal where virtually no systematic information is available for sloth bears living outside of the PAs. We undertook a spatially replicated sign survey‐based single‐season occupancy study intending to overcome this information gap for the sloth bear populations residing in the Trijuga forest of southeast Nepal. Sloth bear sign detection histories and field‐based covariates data were collected between 2 October and 3 December 2020 at the 74 randomly chosen 4‐km2 grid cells. From our results, the model‐averaged site use probability (ψ ± SE) was estimated to be 0.432 ± 0.039, which is a 13% increase from the naïve estimate (0.297) not accounting for imperfect detections of sloth bear signs. The presence of termite mound and the distance to the nearest water source were the most important variables affecting the habitat use probability of sloth bears. The average site‐level detectability (p ± SE) of sloth bear signs was estimated to be 0.195 ± 0.003 and was significantly determined by the index of human disturbances. We recommend considering the importance of fine‐scale ecological and anthropogenic factors in predicting the sloth bear‐habitat relationships across their range in the Churia habitat of Nepal, and more specifically in the unprotected areas.
Impact of micro‐ and macrovascular complications of type 2 diabetes on quality of life: Insights from the DISCOVER prospective cohort study
Authors: Arnold Suzanne V. , Khunti Kamlesh , Tang Fengming , Chen Hungta , Nicolucci Antonio , Gomes Marilia B. , Ji Linong , Shestakova Marina V. , Watada Hirotaka , Cooper Andrew , Fenici Peter , Hammar Niklas , Medina Jesús , Kosiborod Mikhail ,   the DISCOVER investigators
Published: January 2022

Background

The key goals of management in patients with type 2 diabetes (T2D) are to prolong life and improve quality of life. Micro‐ and macrovascular complications of T2D not only increase the risk of morbidity and mortality, but cross‐sectional studies indicate they may also worsen quality of life. We prospectively examined the association of complications that developed during the follow‐up with concurrent changes in quality of life.

Materials and methods

DISCOVER is a multinational, prospective, observational cohort study of T2D patients enrolled at initiation of second‐line glucose‐lowering therapy. Quality of life was assessed with the SF‐36 Physical (PCS) and Mental Components Summary (MCS) scores at baseline, 6 months, and 1, 2 and 3 years. Hierarchical repeated measures regression models for PCS and MCS were constructed with complications included as time‐dependent covariates; first each complication was modelled alone and then second including all interval complications (to account for different complications occurring in the same patient).

Results

Among 7830 patients with T2D from 30 countries (mean age 56.6 years, 47.6% women, mean duration of T2D 5.6 years), baseline mean SF‐36 PCS was 48.0 ± 7.8 and SF‐36 MCS was 45.5 ± 10.4. At baseline, 1422 (18.2%) patients had a known microvascular complication, and 966 (12.3%) had a macrovascular complication. Over the 3 years of the study, 641 (12.0%) developed a new microvascular complication (most commonly neuropathy) and 372 (5.8%) developed a new macrovascular complication (most commonly coronary disease). New diagnoses of coronary disease, peripheral artery disease, heart failure and neuropathy were each associated with subsequent moderate reductions in SF‐36 PCS (range 0.7 to 1.6 points) and new cerebrovascular disease was associated with a reduction in SF‐36 MCS (2.6 points). Results were consistent when all interval complications were considered in the same model.

Conclusion

In a prospective, multinational study of patients with T2D, the development of macrovascular complications and neuropathy was associated with decreases in both physical and mental quality of life. Our results provide additional support for clinicians to focus on the prevention, detection and management of the complications of T2D.
Molecular Reactivity and Interface Stability Modification in In‐Situ Gel Electrolyte for High Performance Quasi‐Solid‐State Lithium Metal Batteries
Authors: Wang Qiyu , Xu Xiangqun , Hong Bo , Bai Maohui , Li Jie , Zhang Zhian , Lai Yanqing
Published: January 2022

Quasi‐solid‐state lithium metal battery is a promising candidate for next generation high energy density and high safety power supply. Despite intensive efforts on electrolytes, uncontrolled interfacial reactions on lithium with electrolyte and patchy interfacial contacts still hinder its practical process. Herein, we bring in rationally designed F contained groups into polymer skeleton via in‐situ gelation for the first time to establish quasi‐solid‐state battery. This method achieves a capacity retention of 90% after 1000 cycles at 0.5C with LiFePO4 cathodes. The interface constructed by polymer skeleton and reaction with –CF3 lead to the predicted solid electrolyte interface species with high stability. Furthermore, we optimize molecular reactivity and interface stability with regulating F contained end groups in the polymer. Comparisons on different structures reveal that high performance solid stable lithium metal batteries rely on chemical modification as well as stable polymer skeleton, which is more critical to construct robust and steady SEI with uniform lithium deposition. New approach with functional groups regulation proposes a more stable cycling process with a capacity retention of 94.2% at 0.5C and 87.6% at 1C after 1000 cycles with LiFePO4 cathodes, providing new insights for the practical development of quasi‐solid‐state lithium metal battery.
Population modeling to inform management and recovery efforts for lake sturgeon, Acipenser fulvescens
Authors: Vaugeois Maxime , Venturelli Paul A. , Hummel Stephanie L. , Forbes Valery E.
Published: January 2022

Lake sturgeon (Acipenser fulvescens) populations have significantly declined across their historic range, in large part due to anthropogenic impacts that have likely been exacerbated by the life-history traits of this slow-growing and long-lived species. We developed a population model to explore how Contaminants of Emerging Concern (CECs) impact lake sturgeon populations. We explored how different physiological modes of action (pMoAs) of CECs impacted population abundance and recovery and how different simulated management actions could enable recovery. We first estimated the impacts on population abundance and recovery by comparing the trajectory of an unexposed population to a population that had been exposed to a CEC with a specific pMoA after the end of the exposure. We then predicted how different management actions would impact population recovery by comparing the trajectories of an unexposed population to an exposed population for which a management action started at a fixed time without discontinuation of the exposure. Our results predicted that the individual-level pMoA of CECs has an important impact on population-level effects because different stressor's pMoA impacts the life-history traits of sturgeon differently. For example, the feeding and reproduction pMoAs caused the strongest and weakest population declines, respectively. For the same reason, pMoA also impacted recovery. For example, recovery was delayed when the pMoA was growth, maintenance, or feeding, but it was immediate when the pMoA was reproduction. We found that management actions that increased the egg survival rate or the stocking of fingerlings resulted in faster and stronger recovery than management actions that increased the juvenile or adult survival rate. This result occurred because the first two management actions immediately impacted recruitment, whereas the impact was delayed for the last two. Finally, there was greater potential for recovery when management action targeted eggs and fingerlings because these life stages have lower natural survival rates. Integr Environ Assess Manag 2022;18:1597–1608. © 2022 Society of Environmental Toxicology & Chemistry (SETAC). This article has been contributed to by US Government employees and their work is in the public domain in the USA.

KEY POINTS

The individual-level physiological mode of action of a stressor is important to forecast its effects at the population level and select the most appropriate management strategy. Management actions that increased egg survival rate or the stocking of fingerlings resulted in faster and stronger recovery than management actions that increased juvenile or adult survival rate. There is a greater potential for recovery when management actions target eggs and fingerlings because these life stages have lower natural survival rates.
Phase Ib study of combinations of avadomide (CC‐122), CC‐223, CC‐292, and rituximab in patients with relapsed/refractory diffuse large B‐cell lymphoma
Authors: Ribrag Vincent , Chavez Julio C. , Boccomini Carola , Kaplan Jason , Chandler Jason C. , Santoro Armando , Corradini Paolo , Flinn Ian W. , Advani Ranjana , Cassier Philippe A. , Sangha Randeep , Kenkre Vaishalee P. , Isufi Iris , Uttamsingh Shailaja , Hagner Patrick R. , Gandhi Anita K. , Shen Frank , Michelliza Sophie , Haeske Harald , Hege Kristen , Pourdehnad Michael , Kuruvilla John
Published: January 2022

There is a need for additional treatment options for patients with relapsed or refractory diffuse large B‐cell lymphoma (DLBCL) who do not benefit from available therapies. We examined combinations of the cereblon E3 ligase modulator (CELMoD) agent avadomide (CC‐122), the selective, ATP‐competitive mammalian target of rapamycin kinase inhibitor CC‐223, and the potent, selective, covalent Bruton tyrosine kinase inhibitor CC‐292 in patients with relapsed/refractory (R/R) DLBCL.

In the multicenter, phase Ib CC‐122‐DLBCL‐001 study (NCT02031419), the dose‐escalation portion explored combinations of CC‐122, CC‐223, and CC‐292 administered as doublets or triplets with rituximab in patients with chemorefractory DLBCL. Primary endpoints were safety, tolerability, and dose‐limiting toxicities; additional endpoints included pharmacokinetics, pharmacodynamics, biomarkers, and preliminary efficacy.

As of December 1, 2017, 106 patients were enrolled across four cohorts. The median age was 65 years (range 24–84 years), and patients had a median of 3 (range 1–10) prior to regimens. A total of 101 patients (95.3%) discontinued, most commonly due to disease progression (49.1%). The most common any‐grade adverse events (AEs) across treatment arms were gastrointestinal and hematologic; the most common grade 3/4 AEs were hematologic. CC‐122 was well tolerated, with no unexpected safety concerns. Preliminary efficacy was observed in three of four treatment arms. CC‐122 plus rituximab was considered suitable for dose expansion, whereas CC‐223 and CC‐292 combinations were associated with enhanced toxicity and/or insufficient improvement in responses.

CC‐122 plus rituximab was well tolerated, with preliminary antitumor activity in patients with R/R DLBCL. This innovative study demonstrates the feasibility of assessing the tolerability and preliminary efficacy of novel combinations utilizing a multi‐arm dose‐finding design.
Exploring the Challenges and Promises of the Annual Symposium on Vehicle Displays and Interfaces
Authors: Pala Silviu
Published: January 2022

Keynotes throughout history address “display & touch with haptics” or “display & directional sound.”