bluuebunny/crossref_metadata_2025 huggingface dataset:
Differences Among Feminist and Non-Feminist Women on Weight Bias Internalization, Body Image, and Disordered Eating
Authors: Martin-Wagar Caitlin A. , Attaway Sarah E. , Melcher Katelyn A.
Published: May 2023

Background Previous research on whether feminist beliefs or self-identification are protective against body image disturbance and eating pathology in non-clinical populations has been variable. Further, no studies have examined feminism among those with diagnosed eating disorders. Additionally, feminist identity has yet to be examined in relation to weight stigma.Methods This study investigated if there are differences in body image, eating pathology, and weight stigma among feminist identity types in two samples using MANCOVAs. Participants completed self-report measures and were women with eating disorders (N = 100) and college women (N = 240).Results Sixty-four percent of the women with eating disorders and 75.8% of the college women identified as a feminist. An independent samples t-test found a significantly higher weight bias internalization in the clinical eating disorder sample than in the college women sample. A MANCOVA in the eating disorder sample found that feminists did not differ from non-feminists on weight bias internalization, body image, or eating pathology. In the college women sample, the MANCOVA also found no statistically significant differences between non-feminist and feminist women.Conclusions Results from this study suggest that sexism and weight stigma may function as self-sustainable systems of oppression. Findings highlight the need for further research investigating its weight bias internalization within eating disorder prevention efforts and interventions.
A synonymous variant in KCNJ11 leading to MODY13: a case report and literature review
Authors: Chen Congli , Piao Yurong , Sang Yanmei
Published: May 2023

137words Background: MODY13 (Maturity-onset diabetes of the young, type 13) is monogenic diabetes associated with the KCNJ11 mutation rarely reported to date. A patient with c.843C>T(p.L281=) in the KCNJ11 gene is reported only in a Chinese patient with congenital hyperinsulinemia. There is no patient diagnosed with MODY13 carrying a synonymous heterozygous variant in the KCNJ11 reported till now. Method: We followed a 9-year-old boy presenting ketosis and diagnosed with MODY13. Whole-exome sequencing (WES) and Sanger validation were performed on the proband and his parents, respectively. Then bioinformatics software was used to predict the RNA structure and protein function. Result: The clinical characteristics and genetic traits of a 9-year-old boy with MODY13 are described in this study. WES revealed the synonymous heterozygous variant c.843C>T (p.L281=) in the KCNJ11 exon 1 in this patient, which prompted the opposite phenotype previously described. The patient and his mother who carries c.843C>T have morphologically comparable RNA structures of KCNJ11 which is completely separated from his mother. Conclusion: A c.843C>T (p.L281=) variant in the KCNJ11 gene contributes to MODY13. In clinical practice, WES should be applied to diagnose hyperglycemia in patients without characteristic clinical symptoms of diabetes to improve prognosis.
Neolamarckia cadambahosts a putative novel deltapartitivirus: a revelation by transcriptome data-mining
Authors: Sidharthan V. Kavi , Ashajyothi Mushineni
Published: May 2023

Neolamarckia cadamba (Roxb.) Bosser is a medicinally important, fast-growing, timber-yielding tree species. In the present study, the virome of N. cadamba was explored using the publicly available N. cadamba transcriptome datasets and a putative novel virus, tentatively named as Neolamarckia cadamba virus 1 (NcV1), was identified. NcV1 contained two genome segments, each coding for a single protein. NcV1 RNA1 (1564 nt) encoded for an RNA dependent RNA polymerase (RdRp) protein while NcV1 RNA2 (1492 nt) encoded for a coat protein (CP). Phylogenetic and sequence similarity analyses revealed the relatedness of NcV1 to pepper cryptic virus 1 and pittosporum cryptic virus 1. Based on the species demarcation criteria, genome organization and phylogeny, NcV1 can be regarded a new member of the genus Deltapartitivirus.
A Case Report on Ayurvedic Management of Paraparesis with Lumbar Radiculopathy
Authors: Rathod Payal , Nakanekar Amit , Jaiswal Rashmi
Published: May 2023

Paraparesis is weakness in bilateral lower limbs. Lumbar radiculopathy is most commonly observed cause of paraparesis. Although surgical intervention is considered as treatment modality; cost and risk of surgery always stood as hurdles in patient care. This condition can be correlated with Katigrahaa (~weakness of lower back), Mansagata Vata (~neuromuscular diseases), Mansakshaya a (~depletion of Mansa), Asthimajjagatavata (~ necrotic condition) in Ayurveda.
56-year-old male presented with complaints of sudden weakness, Tingling, numbness, pain in Bilateral lower limbs, Unable to walk, Restriction of Movement, and pain at lumbar region. Magnetic Resonance Imaging (MRI) of whole spine revealed, severe spinal canal stenosis at L1-L2 disc level and Electro myelogram Nerve Conduction Velocity test showed motor axonopathy in both peroneal, femoral and right posterior tibial nerves. Patient was managed with External and internal Ayurveda treatment modalities. Significant improvement in Visual Analogue Scale (VAS) score from 8 to 2, Western Ontario and McMaster Universities (WOMAC) score from 81 to 24 and Gradually reduction in neurological symptoms was observed. Remission is also absent till next six month.
Ayurvedic treatment can be successfully used in managing paraparesis due to lumbar radiculopathy without any remission of symptoms.
Role of the microbiota in oncogenesis
Authors: Grigorievskaya Z. V. , Petukhova I. N. , Bagirova N. S. , Aginova V. V. , Kononets P. V.
Published: May 2023

Objective. To conduct a systematic analysis of data on the results of studies published in scientific journals on the pro-carcinogenic and anticarcinogenic role of microbiota, as well as on the therapeutic potential of microorganisms in oncogenesis.

Material and Methods. The articles were searched using the Web of Science, Scopus, PubMed, Medline, and eLIBRARY databases. More than 150 sources dedicated to the study of the carcinogenic function of the microbiota and the possible influence of its species and quantitative composition on the efficacy and toxicity of antitumor therapy were found. Data from 71 articles were included in the review.

Results. The relationship between the gut microbiota and cancer is multifactorial and bilateral: pro-carcinogenic on the one hand and anti-carcinogenic on the other hand. Microorganisms can induce tumor growth and cancer development through DNA damage and induction of mutagenesis, trigger oncogenic signals, disruption of barrier function, as well as immune response system disruption. Depletion of microbiota, the development of dysbiosis and induction of chronic inflammatory state are negative factors in the development of cancer. The anticancer effect of microorganisms is presumably based on the production of tumor-suppressive metabolites that function through multiple immune reactions. Maintenance of barrier function, competitive exclusion of pathogenic bacteria, and direct action on immune cells to prevent inflammation are also important protective factors. The presence of intratumor microorganisms in various tumors has been noted. Changes in species and quantitative composition of cancer patients’ microbiota are influenced by diet, taking antibacterial drugs, chemo-, immuno- and radiation therapy. In turn, the microbiota can affect the ongoing treatment. Numerous studies on the influence of the gut microbiota on the efficacy of immunotherapy, particularly in disseminated melanoma, have been conducted. It has been suggested that primary resistance to immunotherapy may be related to the abnormal composition of the gut microbiota. The level of gut microfora composition diversity and the number of Faecalibacterium or Bacteroidales in the fecal microbiota have been suggested to be the predictor of response to anti-PD-1 therapy. To change the composition and activity of the gut microbiota, several therapeutic methods, such as the administration of prebiotics, probiotics, synbiotics, postbiotics, fecal microbiota transplantation, as well as the change in the microbiota composition through a specific diet, are available.
Variability in surgical treatment of metastatic colorectal cancer (literature review)
Authors: Dobrodeev A. Yu. , Kostromitsky D. N. , Afanasyev S. G. , Tarasova A. S. , Babyshkina N. N. , Ponomareva A. A.
Published: May 2023

Background. Colorectal cancer (CRC) is one of the most common cancers and one of the most leading causes of cancer-related deaths worldwide. Approximately 35 % of CRC patients have liver metastases at the time of diagnosis. These patients have a poor prognosis, with the 5-year survival rate of 15 %. Given the poor survival with currently approved methods, the development of the optimal treatment options is needed.

The purpose of the study was to search for data on the development of surgical techniques for the treatment of patients with metastatic CRC (mCRC) with isolated liver metastasis.

Material and Methods. Literature search was carried out in Medline, Cochrane Library, Elibrary and Pubmed databases, including publications characterizing historical and modern results (from 1976 to 2021).

Results. Liver resection in mCRC patients with isolated liver metastasis is the only treatment that offers a chance of increasing the 5-year survival rate up to 45–60 %. Radical surgery should include the removal of the primary tumor and all metastases with negative histological resection margins while preserving sufficient functional liver parenchyma. The paper discusses various approaches to surgical treatment of mCRC patients with liver metastases, with an assessment of their advantages and disadvantages, as well as presents data on perioperative and oncological outcomes.

Conclusion. The surgical treatment strategy should be adapted for each mCRC patient with synchronous liver metastases. The core function of a multidisciplinary team is to determine the patient’s treatment plan combining surgery and systemic chemotherapy, which will improve the immediate and long-term treatment outcomes.
A rare clinical case of a patient with mixed neuroendocrine-non-neuroendocrine neoplasms of the ampulla of vater
Authors: Drozdov E. S. , Grishchenko M. Yu. , Kharitonkin V. I. , Lyan N. I. , Borodin O. Yu. , Fesik E. A. , Korotkevich A. G.
Published: May 2023

Background. Neuroendocrine tumors are rare neoplasias accounting for 1 % of all digestive malignancies. In 2010, mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) were classified by the World Health Organization This type of tumor is extremely rare and most commonly occurs in the appendix, colon, and rectum. To date, only 30 clinical cases of MINEN of the major duodenal papilla (MDP) have been described in the available world literature, while we have not found a description of this pathology in the domestic literature.

Description of the clinical case. We present a case of a 64-year-old male patient with MiNEN MDP. The first clinical manifestation of the disease was obstructive jaundice. To eliminate the jaundice, papillosphincterotomy, transpapillary stenting of the choledochus with a plastic stent was performed. MDP tumor was verifed as adenocarcinoma by histological examination. The patient underwent gastropancreatoduodenal resection. Postoperative immunohistochemical examination showed the expression of antibodies in tumor cells: Synaptophysin (clone 27G12) +++, Chromogranin A (5H7) +, CD 57 (NK-1) ++, Ki 67 (Mib 1) 80 %.

Conclusion: mixed neuroendocrine (G3) non-neuroendocrine carcinoma (G2) of the major duodenal papilla with growth within the wall of the duodenum; metastases of the neuroendocrine component in three lymph nodes, adenocarcinoma metastasis in 1 out of 15 lymph nodes examined; pT2N2M0, MiNEN high grade (classified by S. La Rosa). Conclusion. Mixed neuroendocrine-non-neuroendocrine tumors of MDP are an extremely rare pathology. The accuracy of preoperative morphological diagnostics is not high, therefore, this diagnosis can be easily missed at the preoperative stage. In the morphological study of malignant tumors of MDP, a pathologist should take into account the feasibility of a combination of a neuroendocrine tumor with adenocarcinoma.
The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma
Authors: Golubev P. V. , Bolotina L. V. , Gevorkov A. R. , Deshkina T. I. , Boyko A. V. , Kaprin A. D.
Published: May 2023

Given the favorable prognosis associated with HPV-positive oropharyngeal cancer, cancer care professionals are actively discussing the feasibility of de-escalating treatment strategy for this cohort of patients.

The purpose of the study was to improve the treatment outcomes in patients with locally advanced HPV- positive oropharyngeal squamous cell carcinoma by identifying the optimal induction chemotherapy (ICH) regimen, in particular, by using a two-drug ICH.

Material and Methods. The study included 27 patients with locally advanced (T3–4N0–1, or T1–4N2–3) P16-positive oropharyngeal squamous cell carcinoma. All patients received 3 cycles of ICT according to the TP (docetaxel + cisplatin) regimen. To assess the effect and toxicity of two-drug ICH, a control group of patients, who received ICH according to the standard three-drug TPF (docetaxel, cisplatin and 5FU) regimen, was formed.

Results. In the TP group, complete response (CR) was achieved in 3 (11 %) patients, partial response (PR) in 17 (63 %), stable disease (SD) in 7 (26 %) patients. In the control group: CR 4 (20 %) patients, PR – 13 (60 %), SD – 4 (20 %) patients. The median follow-up time in the TP group was 9 months (range: 2 to 22 months). The 1-year progression-free (PFS) and overall survival (OS) rates were 88.2 % and 100 %, respectively. In the TPF group, the PFS and OS rates were 84.4 % and 100 %, respectively.

Conclusion. The results revealed that TP ICH regimen was non-inferior to the standard TPF regimen in the rates of the objective response, 1-year OS and PFS.
The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer
Authors: Gogieva E. Kh. , Romanov I. S. , Stanyakina E. E. , Berdnikov S. N. , Pimenova E. L. , Umarova A. I.
Published: May 2023

The study objective: to assess the diagnostic value of measuring the concentration of thyroglobulin (Tg) in the washout fluid of the fine needle aspiration (FNA) for the detection of well-differentiated thyroid cancer regional metastases.

Material and Methods. The study included 64 patients with well-differentiated thyroid cancer. Ultrasound examination revealed 71 enlarged regional lymph nodes. The patients underwent simultaneous FNA cytology examination of lymph nodes and the study of Tg concentration in the washout fluid of the needle aspiration. Regional lymph node metastases were verified in 38 patients. These patients underwent surgery. Histological examination of surgical specimens was performed in 43 out of 71 cases.

Results. The sensitivity, specificity, and accuracy of the FNA biopsy and the study of the concentration of thyroglobulin in the in the washout fluid of FNA were 88.5 %, 56.3 %, 76.2 % and 100 %, respectively. The rate of false-positive results of thyroid FNA biopsy was 16 %. The optimal cutoff value for FNA-Tg measurement was 4 g/ml. This made it possible to increase the sensitivity and specificity of the method to 100 %. It was found that the presence of circulating antibodies to Tg in the blood serum had no effect on the diagnostic value of FNA-Tg measurement (p=0.421). There were no statistically significant differences in the levels of thyroglobulin in the in the washout fluid of FNA between patients with Tg concentration above and below the cutoff values (3.9 [0.47; 39.9] ng/ ml vs 12.3 [0.57; 294.8] ng/ml).
On classical and hybrid shadows of quantum states
Authors: Shivam Saumya , von Keyserlingk Curt W. , Sondhi Shivaji L.
Published: May 2023

Classical shadows are a computationally efficient approach to storing quantum states on a classical computer for the purposes of estimating expectation values of local observables, obtained by performing repeated random measurements. In this note we offer some comments on this approach. We note that the resources needed to form classical shadows with bounded relative error depend strongly on the target state. We then comment on the advantages and limitations of using classical shadows to simulate many-body dynamics. In addition, we introduce the notion of a hybrid shadow, constructed from measurements on a part of the system instead of the entirety, which provides a framework to gain more insight into the nature of shadow states as one reduces the size of the subsystem measured, and a potential alternative to compressing quantum states.
Breve estado da arte do sistema brasileiro de classificação de relevo (SBCR):
Authors: Comitê Executivo Nacional – CEN/SBCR
Published: May 2023

Breve estado da arte do SBCR.
Potential of Citrus limetta peel powder (CLPP) for adsorption of hazardous Congo red dye from wastewater
Authors: Aslam Ujala , Javed Tariq
Published: May 2023

In this study, Congo red anionic dye was removed from an aqueous solution using powdered Citrus limetta peel. The adsorbent was evaluated with the use of FTIR and SEM. The highest dye removal was achieved when the operating parameters were optimized, including pH = 6.0, adsorbent dose = 0.4 g, contact time = 90 min, initial adsorbate conc. = 10 ppm, and temperature = 60 °C. The pseudo-second-order model was investigated to have the best fit for the kinetics of the process, with R2 = 0.9918 and Qe(cal) = 0.206 mg g-1, which is very close to the experimental Qe(exp) = 0.191 mg g-1. These two models’ plots showed that both physical and chemical adsorption were feasible. ΔG and ΔH being negative suggest that the adsorption was thermodynamically favorable and spontaneous. Testing the suggested technique with groundwater resulted in an 82% CR adsorption efficiency. Due to the incredible removal capacity of CR dyes from industrial effluents, research suggests that CLPP can be used as substitute adsorbents for the treatment of wastewater from the weaving and dyeing industries.
Mercury and lead pollution in rivers in Ghana: geo-accumulation index, contamination factor, and water quality index
Authors: Anang Emmanuella , Lawson Bernard Walter , Ankrah Aduboffour Victor Kwabena , Tei Meshack , Antwi Anthony Boakye
Published: May 2023

The main environmental problem in Kumasi is water pollution, but little is done about this. Neither water quality nor the degree of heavy metal contamination in Kumasi has been assessed. The degree of mercury and lead pollution in Kumasi was investigated in this study by determining the geo-accumulation index, the contamination factor, and the water quality index (WQI) of mercury and lead in selected rivers in Kumasi. Mercury and lead concentrations were the highest in the Aboabo River, particularly in the Anloga area. This was attributed largely to electronic waste dumping, collection, and processing in the area. The WQI of the rivers indicated that the water was unsuitable for drinking. It is also shown that the water should not be used for crop cultivation or animal rearing, which are among the anthropogenic activities that are both carried out along the rivers, to limit risk to human health.
Investigation into climate change effects on carbon and water fluxes, and water use efficiency of the temperate grassland ecosystems in Inner Mongolia of China
Authors: Wu Zhijun , Li Qiongfang , Xu Shuhong , Chen Qihui , Chen Yunyao
Published: May 2023

The daily gross primary productivity (GPP) and evapotranspiration (ET) in the Xilingol grassland ecosystem of Inner Mongolia were simulated using the BioGeochemical Cycles (Biome-BGC) model for 2003–2019 and under future climate-change scenarios. The system was optimized using the System Response Parameter Calibration Method (SRPCM). The temporal variations of GPP, ET and water use efficiency (WUE) were investigated, and the impacts of precipitation and temperature were explored. Results showed that (i) the BIOME-BGC model performed better when optimized using the SRPCM than by applying the Model-Independent Parameter Estimation approach (PEST); (ii) GPP and ET at annual and seasonal scales showed an insignificant increasing trend; (iii) WUE at the annual scale and in growing seasons showed an insignificant increasing trend and a slight decreasing trend in non-growing seasons; (iv) annual GPP and ET were more sensitive to changes in precipitation than changes in temperature with WUE keeping relatively stable with years; (v) precipitation is a critically controlling factor for GPP and ET in growing seasons and for ET and WUE in non-growing seasons; and (vi) combined temperature and precipitation changes had greater impacts on GPP/ET/WUE than individual changes.
Avaliação da aprendizagem utilizando portfólios digitais
Authors: Cardoso Isis Nalba Albuquerque , Costa Cleide Jane de Sá Araújo , Mercado Luis Paulo Leopoldo
Published: May 2023

Este artigo buscou compreender a avaliação da aprendizagem com a utilização dos portfólios digitais baseado na análise de portfólios produzidos por alunos em uma disciplina no ensino superior. Os portfólios foram produzidos em dupla e alimentados com as atividades propostas pelo professor e com produções próprias, advindas das necessidades de cada aluno. Os dados levantados podem contribuir para reflexões acerca da utilização de portfólios digitais como instrumentos para avaliação e colaborar para que professores que já utilizam ou têm a intenção de utilizar, façam-na conforme os pressupostos da avaliação mediadora. A partir da análise dos portfólios e das respostas dos alunos após questionário aplicado, observamos que os portfólios digitais contribuíram não apenas para a avaliação do professor, mas também para o processo autorreflexivo e construção de conhecimento pelos alunos.
Investigational Agents Targeting SGLT1 and SGLT2 in the Treatment of
Type 2 Diabetes Mellitus
Authors: Cui Haigang , Luo Xin , Chen Mingwei , Lu Jun , Liu Johnson J.
Published: May 2023

Targeting sodium-dependent glucose transporters (SGLT1 and SGLT2) represents a
new class of pharmacotherapy for type 2 diabetes mellitus, a major global health issue with an increasing
social and economic burden. Following recent successes in market approvals of SGLT2 inhibitors,
the ongoing effort has paved the way for the discovery of novel agents via structure-activity
relationship studies, preclinical and clinical testing, including SGLT2 inhibitors, SGLT1/2 dual
inhibitors, and selective SGLT1 inhibitors. A growing understanding of the physiology of SGLTs
allows drug developers to explore additional cardiovascular and renal protective benefits of these
agents in T2DM patients at risk. This review provides an overview of the recent investigational
compounds and discusses future perspectives of drug discovery in this area.
Mesenchymal Stem Cell-derived Type II Alveolar Epithelial Progenitor Cells
Attenuate LPS-induced Acute Lung Injury and Reduce P63 Expression
Authors: Ma Ning , Zhang Mengwei , Xu Guofeng , Zhang Lifang , Luo Min , Luo Meihua , Wang Xing , Tang Hongmei , Wang Xiaoyun , Liu Li , Zhong Xiaolin , Feng Jianguo , Li Yuying
Published: May 2023

Aim:

Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe clinical
respiratory-failure disease mainly characterized by acute damage to the alveolar epithelium and pulmonary
vascular endothelial cells. Stem cell therapy has emerged as a potential regenerative strategy for
ARDS/ALI, however, the outcome is limited, and the underlying mechanisms are unclear.

Introduction:

We established a differentiation system for bone marrow-derived mesenchymal stem cellderived
(BM-MSC) type II alveolar epithelial progenitor cells (AECIIs) and assessed their regulatory
effects on lipopolysaccharide (LPS)-induced ALI.

Methods:

We induced BM-MSC differentiation into AECIIs using a specific conditioned medium. After
26 days of differentiation, 3×105 BM-MSC-AECIIs were used to treat mice with LPS-induced ALI
through tracheal injection.

Results:

After tracheal injection, BM-MSC-AECIIs migrated to the perialveolar area and reduced LPSinduced
lung inflammation and pathological injury. RNA-seq suggested that P63 protein was involved in
the effects of BM-MSC-AECIIs on lung inflammation.

Conclusion:

Our results suggest that BM-MSC-AECIIs may reduce LPS-induced acute lung injury by
decreasing P63 expression.
Non-small Cell Lung Cancer Survival Estimation Through Multi-omic
Two-layer SVM: A Multi-omics and Multi-Sources Integrative Model
Authors: Manganaro Lorenzo , Sabbatini Gianmarco , Bianco Selene , Bironzo Paolo , Borile Claudio , Colombi Davide , Falco Paolo , Primo Luca , Vattakunnel Shaji , Bussolino Federico , Vittorio Scagliotti Giorgio
Published: May 2023

Background:

The new paradigm of precision medicine brought an increasing interest in survival
prediction based on the integration of multi-omics and multi-sources data. Several models have
been developed to address this task, but their performances are widely variable depending on the specific
disease and are often poor on noisy datasets, such as in the case of non-small cell lung cancer
(NSCLC).

Objective:

The aim of this work is to introduce a novel computational approach, named multi-omic twolayer
SVM (mtSVM), and to exploit it to get a survival-based risk stratification of NSCLC patients from
an ongoing observational prospective cohort clinical study named PROMOLE.

Methods:

The model implements a model-based integration by means of a two-layer feed-forward network
of FastSurvivalSVMs, and it can be used to get individual survival estimates or survival-based risk
stratification. Despite being designed for NSCLC, its range of applicability can potentially cover the full
spectrum of survival analysis problems where integration of different data sources is needed, independently
of the pathology considered.

Results:

The model is here applied to the case of NSCLC, and compared with other state-of-the-art
methods, proving excellent performance. Notably, the model, trained on data from The Cancer Genome
Atlas (TCGA), has been validated on an independent cohort (from the PROMOLE study), and the results
were consistent. Gene-set enrichment analysis of the risk groups, as well as exome analysis, revealed
well-defined molecular profiles, such as a prognostic mutational gene signature with potential
implications in clinical practice.
p-Coumaric Acid Inhibits Osteosarcoma Growth by Inhibiting PI3K/Akt Signaling
Pathway
Authors: Yang Bo , Wang Bowen , Wang Guoliang , Cao Wenliang , Wang Qian , Pu Hao , An Wei
Published: May 2023

Background:

Background: P-coumaric acid (p-CA) is a kind of phenylpropionic acid derived from aromatic amino acids,
which is widely distributed in many plants and human diets. It has strong pharmacological and inhibitory effects on a
variety of tumors. However, the role of p-CA in osteosarcoma, a tumor with a poor prognosis, is still unknown. Therefore,
we aimed to evaluate the effect of p-CA on osteosarcoma and explore its potential mechanism.

Objective:

This study aimed to investigate whether p-CA has an inhibitory effect on the growth of osteosarcoma cells
and explore its potential mechanism.

Methods:

Methods: MTT assay and clonogenic assay were used to detect the effect of p-CA on the proliferation of osteosarcoma
cells. The effect of p-CA on apoptosis of osteosarcoma cells was detected by the Hoechst staining and flow cytometry.
The effects of p-CA on the migration and invasion of osteosarcoma cells were detected by scratch healing assay and
Transwell invasion assay. Western blot and PI3K/Akt pathway activator 740Y-P were used to detect the anti-tumor
mechanism of p-CA on osteosarcoma cells. The effect of p-CA on osteosarcoma cells in vivo was verified by an orthotopic
osteosarcoma tumor animal model in nude mice.

Results:

MTT assay and clonogenic assay showed that p-CA inhibited the proliferation of osteosarcoma cells. Hoechst
stain and flow cytometry showed that p-CA could induce apoptosis of osteosarcoma cells and lead to G2 phase arrest
of osteosarcoma cells. Transwell assay and scratch healing assay found that p-CA could inhibit the migration and invasion
of osteosarcoma cells. Western blot showed that p-CA could inhibit the activity of the PI3K/Akt signaling pathway
in osteosarcoma cells, and 740Y-P could reverse its inhibitory effect. In vivo mouse models, p-CA has an antitumor
effect on osteosarcoma cells in vivo, and at the same time, it has less toxic side effects on mice.

Conclusion:

This study demonstrated that p-CA could effectively inhibit the proliferation, migration and invasion of
osteosarcoma cells and promote apoptosis. p-CA may play an anti-osteosarcoma role by inhibiting PI3K/Akt signaling
pathway.
Emerging Nanotechnology for the Treatment of Alzheimer’s Disease
Authors: Singh Aditya , Ansari Vaseem Ahamad , Mahmood Tarique , Ahsan Farogh , Wasim Rufaida , Maheshwari Shubhrat , Shariq Mohammad , Parveen Saba , Shamim Arshiya
Published: May 2023

Nanotechnology is a great choice for medical research, and the green synthesis approach is
a novel and better way to synthesize nanoparticles. Biological sources are cost-effective, environmentally
friendly, and allow large-scale production of nanoparticles. Naturally obtained 3 β-hydroxy-urs-
12-en-28-oic acids reported for neuroprotective and dendritic structure are reported as solubility enhancers.
Plants are free from toxic substances and act as natural capping agents. In this review, the
pharmacological properties of ursolic acid (UA) and the structural properties of the dendritic structure
are discussed. UA acid appears to have negligible toxicity and immunogenicity, as well as favorable
biodistribution, according to the current study, and the dendritic structure improves drug solubility,
prevents drug degradation, increases circulation time, and potentially targets by using different pathways
with different routes of administration. Nanotechnology is a field in which materials are synthesized
at the nanoscale. Nanotechnology could be the next frontier of humankind's technological advancement.
Richard Feynman first used the term ‘Nanotechnology’ in his lecture, “There is Plenty of
Room at the Bottom”, on 29th December, 1959, and since then, interest has increased in the research
on nanoparticles. Nanotechnology is capable of helping humanity by solving major challenges, particularly
in neurological disorders like Alzheimer's disease (AD), the most prevalent type, which may account
for 60-70% of cases. Other significant forms of dementia include vascular dementia, dementia
with Lewy bodies (abnormal protein aggregates that form inside nerve cells), and a number of illnesses
that exacerbate frontotemporal dementia. Dementia is an acquired loss of cognition in several cognitive
domains that are severe enough to interfere with social or professional functioning. However,
dementia frequently co-occurs with other neuropathologies, typically AD with cerebrovascular dysfunction.
Clinical presentations show that neurodegenerative diseases are often incurable because patients
permanently lose some neurons. A growing body of research suggests that they also advance our
knowledge of the processes that are probably crucial for maintaining the health and functionality of the
brain. Serious neurological impairment and neuronal death are the main features of neurodegenerative
illnesses, which are also extremely crippling ailments. The most prevalent neurodegenerative disorders
cause cognitive impairment and dementia, and as average life expectancy rises globally, their effects
become more noticeable.
Nutrition, Immunity and Aging: Current Scenario and Future
Perspectives in Neurodegenerative Diseases
Authors: Barbero Mazzucca Camilla , Cappellano Giuseppe , Chiocchetti Annalisa
Published: May 2023

Aging is a gradual decline of physiological function and tissue homeostasis and, in many
instances, is related to increased (neuro)-degeneration, together with inflammation, becoming one of
the most important risks for developing neurodegenerative diseases. Certain individual nutrients or
foods in combination may counteract aging and associated neurodegenerative diseases by promoting a
balance between the pro- and anti-inflammatory responses. Thus, nutrition could represent a powerful
modulator of this fine balance, other than a modifiable risk factor to contrast inflammaging. This narrative
review explores from a broad perspective the impact of nutrition on the hallmarks of aging and
inflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis
Syndrome (ALS), starting from nutrients up to single foods and complex dietary patterns.
Study of coherent population trapping and AC Stark effect in ensembles of NV-centers in diamond at room temperature in microwave range
Authors: Akhmedzhanov R. A.  , Gushchin L. A.  , Zelensky I. V.  , Mitrofanova T.G.  , Nizov V. A.  , Nizov N. A.  , Sobgaida D. A.
Published: May 2023

We study coherent population trapping and AC Stark effect using microwave transitions between the sublevels of the ground state of the NV-center. Sublevels with different projections of the nuclear spin of the nitrogen atom are used to implement the -scheme. Dependence of the characteristics of the coherent population trapping dip on the control field frequency and intensity is studied. Various schemes for observing the AC Stark effect are considered. Keywords: NV-center, coherent population trapping, AC Stark.
Analysis of the characteristics of a waveguide device for combining external optical beams
Authors: Nalivaiko V.I.  , Ponomareva M. A.
Published: May 2023

The design of a planar waveguide combiner of light beams, which performs the summation of a set of external light beams, is proposed. Combiner design options are considered and a 3D version with optical decoupling is proposed. The calculations of the operating parameters of the elements of the combiner depending on the values of the refractive indices of the layers of the structure are done. The minimum dimensions of the input/output diffractive elements of the combiner are estimated. Keywords: optical integrated circuits, optical beam combiner, diffraction grating, waveguide.
Versatile Tunable Microresonator for the Light-Matter Interaction Studying in the Strong-Coupling Mode
Authors: Mochalov K. E.  , Samokhvalov P. S.  , Gun'ko Yu. K.
Published: May 2023

The interaction between an ensemble of molecules and an electromagnetic field in a highly limited volume makes it possible to control the properties of a substance and, therefore, is an exceptionally promising area of research. The most common way to achieve weak or strong light-matter coupling is to place an ensemble of molecules in a micron-sized resonator. In such a system,the interaction of light with matter appears in the form of a change in the spectral response of the system, which depends on the strength of the coupling between the ensemble of molecules and the modes of the resonator. Currently, there is no general and user-friendly approach that allows studying a lot of different samples in a wide optical range using the same resonator setup. The present paper describes the design of a device that makes it possible to overcome this disadvantage, speed up and facilitate the study of the light-matter interaction, and also obtain weak and strong light-matter coupling modes for a large number of samples in the UV, visible, and IR regions of the optical spectrum. The device developed here is based on the tunable unstable λ/2 Fabry-Perot microresonator, consisting of flat and convex mirrors, which satisfy the condition of plane-parallelism at least at one point of the curved mirror and can significantly reduce the mode volume. The device was used to study the effect of the strong-coupling regime on the fluorescent properties of the Rhodamine 6G (R6G) dye embedded in a boron nitride nanoparticles matrix. It was found that the use of boron nitride (h-BN) as a carrier matrix has an orienting effect on the dye molecules, that results in an increase of the light-matter coupling strength at a lower resonator mode energy required. Keywords: microspectroscopy, optical microresonator, strong coupling, boron nitride.
Oxygen Defects in Single-Wall Carbon Nanotubes for Near-Infrared Light Emitters
Authors: Eremin T. V.  , Eremina V. A.  , Obraztsova E.D.
Published: May 2023

A new peak with an increased intensity was observed in the photoluminescence (PL) spectra of single-walled carbon nanotubes (SWCNTs), exposed to UV irradiation in the presence of sodium hypochlorite. It was concluded on the basis of the spectroscopic data that the new PL peak is associated with oxygen defects in the SWCNT structure. The impact of environmental acidity on the optical properties of oxygen-doped SWCNTs (O-SWNTs) was investigated. An increased sensitivity of the new PL peak to the pH of the medium was observed. It was concluded that the usage of a pH-neutral medium is of crucial importance for the creation of IR light sources based on O-SWNTs. Keywords: single-walled carbon nanotubes, photoluminescence, localized exciton, acidity, infrared light emitters.
Modelling of the dependence of charge transport in organic layer, containing crystallites, on the layer morphology
Authors: Nikitenko V. R.  , Burdakov Ya. V.  , Saunina A. Yu.
Published: May 2023

A Monte Carlo simulation of the charge carrier mobility in a polymer layer with a thickness of about 100 nm, containing both nanosized crystallites and disordered (amorphous) regions, has been carried out. The mobility has a maximum at a certain energy depth of crystallites. The mobility increases along with an increase in the fraction of crystallites and can exceed its value for the case of disordered material by several orders of magnitude.. Keywords: disordered polymers, thin polymer layer morphology.
Dynamics of ions in the plume of the stationary plasma thruster operating with Krypton
Authors: Merkurev D. V.  , Baranov S. V.  , Kim V. P.  , Melnikov A. V.  , Shilov E. V.
Published: May 2023

The results of the spatial accelerated ion flow density distribution and of the mean energy of ions exhausting thruster and moving in the different directions in the plume of the stationary plasma thruster operating with Krypton of the experimental SPT model of new scheme operating with Krypton are presented in the given paper. There are also presented the results of the directed radial and "back" ion flows in the vicinity of the mentioned SPT experimental model. Keywords: Stationary Plasma Thruster, gas discharge, crossed electric and magnetic fields, propellant flow ionization and accleration, plume divergence, radial and "back" ion flows.
Percolative charge transport on electrified surface of polytetrafluoroethylene
Authors: Kuzmin Yu. I.
Published: May 2023

The charge transport on the electrically charged surface of polytetrafluoroethylene (PTFE) films in the presence of the adsorption of an electrically conductive phase has been studied. The attenuation of the rate of displacement of the potential drop over the film surface, which limits the area of its expansion, has been found. An estimate has been made for the critical index of the correlation length of a percolation cluster that forms on an electrified PTFE surface at high humidity. It has been experimentally established that the leak of charge from an electrically charged surface is determined by percolation processes. Keywords: percolation, percolation threshold, adsorption, electrization.
SiC/graphene-based test structures for the Kelvin probe microscopy instrumental function determination
Authors: Dunaevskiy M. S.  , Gushchina E. V.  , Malykh D. A.  , Lebedev S. P.  , Lebedev A. A.
Published: May 2023

The paper proposes a method for determining the instrumental function for measuring the surface potential in the Kelvin probe microscopy mode. The method is based on the use of SiC samples with regions of single-layer and double-layer graphene as a test structure. The measurement of potential profiles along different directions on such a surface makes it possible to determine the instrumental function for measurements of the potential. Using the instrumental function, one can perform a deconvolution procedure and restore the exact surface potential. Keywords: Scanning probe microscopy, Kelvin probe microscopy, deconvolution, graphene, silicon carbide.
Ion-plasma deposition of multicomponent films with a given law of composition distribution by thickness
Authors: Kozyrev A. B.  , Volpyas V. A.  , Tumarkin A. V.  , Altynnikov A.G.  , Komlev А. Е.  , Platonov R. A.  , Trofimov P M.
Published: May 2023

A method is proposed for ion-plasma deposition of thin multicomponent films with the ability to control the component composition in thickness (graded film) with a change in the pressure of the working gas according to a given law. Using the BaxSr1-xTiO3 (BSTO)perovskite-type structure as an example, the calculated (Monte Carlo simulation) and experimental dependences of the component composition of films and their deposition rate on the pressure of the working gas were obtained. As an example, the possibility of deposition of BSTO films with a linear distribution of composition by their thickness. Keywords: ion-plasma deposition, thin multicomponent films, composition control.
Degradation processes in a memristor based on germanium selenide with a self-forming conductive channel
Authors: Aleshin A. N.  , Ruban O. A.
Published: May 2023

The effect of temperature on degradation processes in an Ag/SnSe/Ge2Se3/W ionic memristor with a self-forming conductive channel in the temperature range of 22-65oC at a switching frequency of 100 Hz was studied based on determining the electrical conductivity of the memristor in low-resistance and high-resistance modes of operation. It has been established that at elevated temperatures, degradation processes occur faster and affect both the low-resistance and high-resistance modes of operation of the memristor. The degradation activation energy was determined to be 1.16 eV. Keywords: electrical conductivity, solid electrolyte, degradation, conductive channel.
शिक्षा के अधिकार अधिनियम में सतत् एवं व्यापक मूल्याँकन
Authors: सिंह मृदुल कुमार
Published: May 2023

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EMPOWERMENT AMONG GIRLS’ STUDYING IN SENIOR SECONDARY SCHOOLS IN RELATION TO THEIR PARENTAL RELATIONSHIP
Authors: Kumar Devender
Published: May 2023

The present study provides knowledge and information about the empowerment level of girls and also its relationship with their parents. There is lack of researches in this area of girls’ empowerment especially with regard to their parental relationship. Empowered women lead to economic development and social progress of the nation. The study is helpful to the teachers, policy makers, bureaucrats, researchers, scholars, educators, and politicians because it gives understanding of how relationship of parents helps the girls’ in their empowerment. The present study was conducted through the survey method under descriptive method of research. Survey studies are conducted to collect detailed description of existing phenomenon with the intent of employing data justify current condition practices or to make more intelligent. A representative sample of 316 girls studying in class 10+1 and 10+2 was selected by using multistage random sampling technique Research Tools Used In order to collect the requisite data, following research tools were used. The data on empowerment among girls’ was verified for normality by calculating certain statistics like mean, median, mode, standard deviation, quartile deviation, kurtosis and skewness.
AN APPRAISAL OF BISHNOI MOVEMENT
Authors: Mondal Mitra
Published: May 2023

The Bishnoi are one of the first community in India, who give emphasis on environment conservation and wildlife protection in their lives. They are also known as the first environmentalists of India. They showed the real path of sustainable development through simple approach to life. In 1730 AD they sacrificed their lives to save the environment. This paper depicts the faith of Bishnoi about nature and in conservation of environment. It also highlights on Bishnoi movement and concludes that they teach us how to protect trees to save our planet.
EMERGING ISSUES AND CHALLENGES OF HIGHER EDUCATIONS IN INDIA
Authors: Kumar J Manoj
Published: May 2023

India’s higher education system is the world’s third largest in terms of students, next to China and the United States. Unlike China, however, India has the advantage of English being the primary language of higher education and research. India educates approximately 11 per cent of its youth in higher education as compared to 20 per cent in China. The main governing body at the tertiary level is the UGC (University Grants Commission) in India, which enforces its standards, advises the government, and helps coordinate between the centre and the state. Universities and its constituent colleges are the main institutes of higher education in India. Higher education makes individual free from ignorance and superstitions, it is the directive to bridge the knowledge gap between countries and communities enriching dialogues between people, culture, international living and networking of ideas, research and technologies.It is the quality of higher education that decides the quality of human resources of the country. This paper highlights the issues and challenges which are the real hindrances for harmonious development in higher education system and the suggestions for overcoming it because the quality higher education can only eliminate the root of the problems.
DIGITAL LITERACY AND COMPETENCE FOR EDUCATORS
Authors: Sharma Rajesh Kumar , Sharma Deeksha
Published: May 2023

Over the last few decades concept of digital literacy and digital competence have been widely used in public discourse. These are the latest concepts, skills necessary for modern life, concerned with the scientific and technical implementation of new emerging technology in various aspects of life such as education, economy, politics and production. The development of these digital concepts depends upon both traditional and diverse media. Digital literacy is a skill that provides plenty of opportunities to the person in current digital environment, so that it can be called a new modern skill. Digitally literate teachers can facilitate and equip their students with modern skills in the competitive world. Use of digital devices and Information and communication technology exposes the students to a new approach in teaching and learning. The paper discusses the significance of teacher’s awareness to digital literacy and competence vis a vis the use of digital devices to create the digital environment in the classroom.
PROFESSIONAL ETHICS IN TEACHER EDUCATION
Authors: Gaur Homesh Rani
Published: May 2023

Ethics is the theoretical basis for practicing morality in daily life. Ethics guide us to follow ideal and justified life style in the society. It means Ethics are a set of standards set by society which help an individual and evaluate the morality of his commitments and actions. An ethical analysis will lead an individual to think critically what is to be done and what is not to be done. Ethics are an indispensable instrument for the ideal society. ‘Ethics’ word has been derived from the ancient Greek word “ethikos” that means related to one’s character.’ Ethikos’ originated from the root word ethos, which means “character or moral nature.” Ethics and morals are similar in the way they discriminate between right and wrong. They ensure wellness of the society. Immanuel Kant appropriately remarked “Ethics is knowing the difference between what you have a right to do and what is right to do.”