bluuebunny/crossref_metadata_2025 huggingface dataset:
Can IL-33 and Endocan be New Markers for Retinopathy of Prematurity?
Authors: Cakir Ufuk , Tayman Cuneyt , Yucel Cigdem , Ozdemir Ozdemir
Published: March 2019

Background:

Retinopathy of Prematurity (ROP) is a pathophysiologic condition of the
retina due to abnormal proliferation of retinal vessels.

Objective:

The study aimed too ascertain the importance of vascular endothelial growth factor
(VEGF), insulin-like growth factor-1 (IGF-1), interleukin-33 (IL-33) and endocan in the diagnosis
and follow-up of ROP.

Methods:

This prospective cohort study was conducted in the neonatal intensive care unit (NICU)
of Health Science University, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey,
between February 2017 and August 2018. Preterm infants (gestational age (GA) of ≤32 weeks and
birth weight of ≤1500 gr), diagnosed ROP were included in the study. VEGF, IGF-1, IL-33 and
endocan levels were evaluated in the cord blood and in the serum before and after treatment of
infants in the ROP and control groups.

Results:

A final number of 146 infants were included in the study. During the study period, 73
infants were identified as the ROP group, and 73 infants were allocated as the control group. In the
ROP group, the cord blood VEGF value was higher than the control group (p <0.05). However,
IGF-1 levels in the cord blood were lower in the ROP group than control (P<0.05). IL-33 and
endocan values in the cord blood were similar in both control and ROP groups (p>0.05). Although
serum levels of IL-33, VEGF and endocan were higher before laser treatment, these biomarkers
decreased significantly after laser treatment (p <0.05).

Conclusion:

We determined that serum IL-33 and endocan levels might be suggested as sensitive
novel markers for the prediction of severe ROP.
A Revolution in Reprogramming: Small Molecules
Authors: Zhou Jin , Sun Jie
Published: March 2019

Transplantation of reprogrammed cells from accessible sources and in vivo reprogramming are potential therapies for regenerative medicine. During the last decade, genetic approaches, which mostly involved transcription factors and microRNAs, have been shown to affect cell fates. However, their potential carcinogenicity and other unexpected effects limit their translation into clinical applications. Recently, with the power of modern biology-oriented design and synthetic chemistry, as well as high-throughput screening technology, small molecules have been shown to enhance reprogramming efficiency, replace genetic factors, and help elucidate the molecular mechanisms underlying cellular plasticity and degenerative diseases. As a non-viral and non-integrating approach, small molecules not only show revolutionary capacities in generating desired exogenous cell types but also have potential as drugs that can restore tissues through repairing or reprogramming endogenous cells. Here, we focus on the recent progress made to use small molecules in cell reprogramming along with some related mechanisms to elucidate these issues.
Identifying the Potential Substrates of the Depalmitoylation Enzyme Acyl-protein Thioesterase 1
Authors: Liu Huicong , Yan Peipei , Ren Junyan , Wu Can , Yuan Wei , Rao Muding , Zhang Zhongjian , Kong Eryan
Published: March 2019

Background:

The homeostasis of palmitoylation and depalmitoylation is involved in various cellular processes, the disruption of which induces severe physiological consequences. Acyl-protein thioesterase (APT) and palmitoyl-protein thioesterases (PPT) catalyze the depalmitoylation process. The natural mutation in human PPT1 caused neurodegenerative disease, yet the understanding of APT1 remains to be elucidated. While the deletion of APT1 in mice turned out to be potentially embryonically lethal, the decoding of its function strictly relied on the identification of its substrates.

Objective:

To determine the potential substrates of APT1 by using the generated human APT1 knockout cell line.

Methods :

The combined techniques of palmitoyl-protein enrichment and massspectrometry were used to analyze the different proteins. Palmitoyl-proteins both in HEK293T and APT1-KO cells were extracted by resin-assisted capture (RAC) and data independent acquisition (DIA) quantitative method of proteomics for data collection.

Results:

In total, 382 proteins were identified. The gene ontology classification segregated these proteins into diverse biological pathways e.g. endoplasmic reticulum process and ubiquitin-mediated proteolysis. A few potential substrates were selected for verification; indeed, major proteins were palmitoylated. Importantly, their levels of palmitoylation were clearly changed in APT1-KO cells. Interestingly, the proliferation of APT1-KO cells escalated dramatically as compared to that of the WT cells, which could be rescued by APT1 overexpression.

Conclusion:

Our study provides a large scale of potential substrates of APT1, thus facilitating the understanding of its intervened molecular functions.
Molecular Chaperone HSP70 and Key Regulators of Apoptosis - A Review
Authors: Roufayel Rabih , Kadry Seifedine
Published: March 2019

Identified as a molecular chaperone constitutively being synthesized due to enhanced elevated temperature change, this heat shock protein HSP70 has shown to be intimately involved in many protein biogenesis, facilitating the synthesis and folding of proteins and trafficking of nascent peptides during cell growth. HSP70 also plays a vital role in protein assembly, regulation and interaction with a wide variety of proteins. Stress-induced cell death is under the control of the Bcl-2 family of apoptotic regulators and display either pro-apoptotic or anti-apoptotic activities. Subjected to stress conditions such as heat shock, cells have been reported to express elevated expressions of HSP70. Moreover, this molecular chaperon has shown to act at multiple levels to suppress stressed-induced apoptotic signals of some Bcl-2 members by repairing, re-synthesizing damaged proteins, and stabilizing unfolded proteins. Therefore, HSP70 synthesis can act as an essential recovery mode for cellular survival and adaptation during lethal conditions.
Polyisoprenylated Cysteinyl Amide Inhibitors Deplete K-Ras and Induce Caspase-dependent Apoptosis in Lung Cancer Cells
Authors: Nkembo Augustine T. , Amissah Felix , Ntantie Elizabeth , Poku Rosemary A. , Salako Olufisayo O. , Ikpatt Offiong Francis , Lamango Nazarius S.
Published: March 2019

Background:

Non-small cell lung cancers (NSCLC) harboring mutation-induced dysregulation
of Ras signaling present some of the most difficult-to-manage cases, since directly targeting
the constitutively active mutant Ras proteins has not resulted in clinically useful drugs. Therefore,
modulating Ras activity for targeted treatment of cancer remains an urgent healthcare need.

Objective:

In the current study, we investigated a novel class of compounds, the polyisoprenylated
cysteinyl amide inhibitors (PCAIs), for their anticancer molecular mechanisms using the NSCLC
cell panel with K-Ras and/or other mutant genes.

Methods:

The effect of the PCAIs on intracellular K-Ras levels, cell viability, apoptosis, spheroid
and colony formation were determined.

Results:

Treatment of the lung cancer cells with the PCAIs, NSL-RD-035, NSL-BA-036, NSL-BA-
040 and NSL-BA-055 resulted in concentration-dependent cell death in both K-Ras mutant (A549,
NCI-H460, and NCI-H1573), N-Ras mutant (NCI-H1299) and other (NCI-H661, NCI-H1975, NCIH1563)
NSCLC cells. The PCAIs at 1.0 -10 μM induced the degeneration of 3D spheroid cultures,
inhibited clonogenic cell growth and induced marked apoptosis via the extrinsic pathway. The most
potent of the PCAIs, NSL-BA-055, at 5 μM induced a seven-fold increase in the activity of caspase-
3/7 and a 75% selective depletion of K-Ras protein levels relative to GAPDH in A549 cells that correlated
with PCAIs-induced apoptosis. NSL-BA-040 and NSL-BA-055 also induced the phosphorylation
of MAP kinase (ERK 1/2).

Conclusion:

Taken together, PCAIs may be potentially useful as targeted therapies that suppress
NSCLC progression through disruption of Ras-mediated growth signaling.
Inhibition of PI3K/mTOR Pathways with GDC-0980 in Pediatric Leukemia: Impact on Abnormal FLT-3 Activity and Cooperation with Intracellular Signaling Targets
Authors: Al-Ghabkari Abdulhameed , Perinpanayagam Maneka A. , Narendran Aru
Published: March 2019

Background:

GDC-0980 is a selective small molecule inhibitor of class I PI3K and mTOR pathway with a potent anti-proliferative activity.

Objective:

We set out to evaluate the efficacy of GDC-0980, in pre-clinical studies, against pediatric leukemia cells.

Methods:

The anti-neoplastic activity of GDC-0980 was evaluated in vitro using five different pediatric leukemia cells.

Results:

Our data show that GDC-0980 significantly inhibited the proliferation of leukemia cell lines, KOPN8 (IC50, 532 nM), SEM (IC50,720 nM), MOLM-13 (IC50,346 nM), MV4;11 (IC50,199 nM), and TIB-202 (IC50, 848 nM), compared to normal control cells (1.23 µM). This antiproliferative activity was associated with activation of cellular apoptotic mechanism characterized by a decrease in Bcl-2 protein phosphorylation and enhanced PARP cleavage. Western blot analyses of GDC-0980 treated cells also showed decreased phosphorylation levels of mTOR, Akt and S6, but not ERK1/2. Notably, FLT3 phosphorylation was decreased in Molm-13 and MV4;11 cells following the application of GDC-0980. We further examined cellular viability of GDC-0980-treated primary leukemia cells isolated from pediatric leukemia patients. This study revealed a potential therapeutic effect of GDC-0980 on two ALL patients (IC50’s, 1.23 and 0.625 µM, respectively). Drug combination analyses of GDC-0980 demonstrated a synergistic activity with the MEK inhibitor Cobimetinib (MV4-11; 11, CI, 0.25, SEM, CI, 0.32, and TIB-202, CI, 0.55) and the targeted FLT3 inhibitor, Crenolanib (MV4-11; 11, CI, 0.25, SEM, CI, 0.7, and TIB-202, CI, 0.42).

Conclusion:

These findings provide initial proof-of-concept data and rationale for further investigation of GDC-0980 in selected subgroups of pediatric leukemia patients.
Foeniculum Vulgare and Pelargonium Graveolens Essential Oil Mixture Triggers the Cell Cycle Arrest and Apoptosis in MCF-7 Cells
Authors: El-Garawani Islam , El Nabi Sobhy Hassab , Nafie Ebtesam , Almeldin Samar
Published: March 2019

Background:

Fennel (Foeniculum vulgare) and rose geranium (Pelargonium graveolens) oils are known for their various biological effects including anticancer properties.

Objective:

This study aimed to evaluate the anticancer mechanism of fennel and geranium oils combined treatment on MCF-7 cells.

Methods:

The GC-MS method for essential oil characterization as well as the in vitro cytotoxicity, morphological changes, real-time PCR and immunocytochemical investigation for apoptosis-related markers, in addition, to flow cytometric cell cycle distribution analysis were done.

Results:

The major constituents of both essential oils were anethole (55.33 %) and estragole (11.57 %) for fennel essential oil. However, cintronellol (34.40 %) and geraniol (8.67 %) were identified in geranium oil. The results revealed an IC50 of 220±5.7 and 60±2.1µg/ml for fennel and geranium oils, respectively. The mechanistic anticancer properties were investigated throughout the 70, 50, and 25µg/ml of oils mixture. The marked apoptotic morphology and the flow cytometric cell cycle distribution analysis in addition to the levels of apoptosisrelated makers such as p53, caspase-3, mir-21, mir-92a, Bcl-2, and ki-67 confirmed that fennel and geranium oils combination induced cell cycle arrest and apoptosis in MCF-7 cells. Moreover, the oils mixture did not exert any significant (P<0.01) toxicity on normal human peripheral blood lymphocytes in vitro.

Conclusion:

The findings showed that the mixture of oils exerted selective cytotoxicity towards MCF-7 cells through induction of cell cycle arrest and apoptosis which may be triggered by the synergistic effect between the active ingredients of fennel and geranium oils.
Computational Drug Designing and Prediction Of Important Parameters Using in silico Methods- A Review
Authors: Khan Tahmeena , Lawrence Alfred J. , Azad Iqbal , Raza Saman , Joshi Seema , Khan Abdul Rahman
Published: March 2019

Background::

Computational or in silico studies are undertaken to assess the drug like properties of lead compounds. These studies help in fast prediction of relevant properties.

Objective: :

Through this review, an effort is made to encapsulate some of the important parameters which should be met by a compound for it to be considered as a potential drug candidate along with an overview of automated softwares which can be used for making various predictions.

Methods::

Drug uptake, its absorption, evacuation and associated hazardous effects are important factors for consideration in drug designing and should be known in early stages of drug development. Several important physicochemical properties like molecular weight, polar surface area (PSA), molecular flexibility etc. have to be taken into consideration in drug designing. Toxicological assessment is another important aspect of drug discovery which predicts the safety and adverse effects of a drug.

Results: :

Additionally, bioactivity scores of probable drug leads against various human receptors can also be predicted to evaluate the probability of them to act as a potential drug candidate. The in vivo biological targets of a molecule can also be efficiently predicted by molecular docking studies.

Conclusion::

Some important software like iGEMDOCK, AutoDock, OSIRIS property explorer, Molinspiration, MetaPrint2D, admetSAR and their working methodology and principle of working have been summarized in this review.
Sex-Related Differences in Plasma Oxytocin Levels in Humans
Authors: Marazziti Donatella , Baroni Stefano , Mucci Federico , Piccinni Armando , Moroni Ilenia , Giannaccini Gino , Carmassi Claudia , Massimetti Enrico , Dell’Osso Liliana
Published: March 2019

Background:

Increasing evidence supports a key role of Oxytocin (OT) as a modulator of social relationships in mammals.

Objective:

The aim of the present study was to investigate possible sex-related differences in plasma OT levels in human beings.

Methods:

Forty-five healthy men and 45 women (mean age: 34.9 ± 6.2 years), were included in the study. Plasma preparation, peptide extraction and OT radioimmunoassay were carried out according to standardized methods.

Results:

The results showed that OT plasma levels (pg ̸ ml, mean ± SD) were significantly higher in women than in men (4.53 ± 1.18 vs 1.53 ± 1.19, p ˂ 0.001).

Conclusions:

The present finding demonstrates sex-related differences in plasma OT levels in humans. It is tempting to hypothesize that such differences might be related to behaviours, attitudes, as well as susceptibility to stress response, resilience and social emotions specific of women and men.
A Brief History of Modern Endocrinology and Definitions of a True Hormone
Authors: Bahadoran Zahra , Mirmiran Parvin , Azizi Fereidoun , Ghasemi Asghar
Published: March 2019

Background and Objective:

An overview of the history of endocrinology indicates that
definitions of some initially developed concepts, including the term ‘hormone’ have been changed over
time. This review provides a historical overview of current definitions of ‘hormone’ and the criteria of
a true hormone. In addition, a brief history of hormone-related concepts and their transformation over
time are discussed.

Results:

Classically, a hormone is a chemical substance secreted into the bloodstream and acts on distant
tissues, usually in a regulatory fashion. Several newly discovered bioregulators and chemical signaling
molecules are far from the classical definition of a true hormone and could not fulfill many relevant
criteria. Major developments in the field of endocrinology accompanied by the complex terminology,
currently used to describe hormonal actions of chemical messengers, underscore the need of the
revision of such classical concepts.

Conclusion:

Complex terminology currently used to describe different hormonal actions of chemical
messengers, suggests that it is time to conceptualize the term hormone and revise its classical definition.
Impaired Myocardial MIF/AMPK Activation Aggravates Myocardial Ischemia Reperfusion Injury in High-Fat Diet-Induced Obesity
Authors: Meng Fanqing , Li Dongliang , Song Bingfeng , Li Liang
Published: March 2019

Background:

Obese patients are more sensitive to myocardial ischemia, which has been
linked with high mortality rates. The following study investigates the effects of impaired macrophage
Migration Inhibitory Factor (MIF)/AMP-Activated Protein Kinase (AMPK) activation on increased
susceptibility to myocardial ischemia/reperfusion (I/R) in high-fat diet-induced obesity.

Methods:

Male C57BL/6J mice were fed with a normal diet (10% kcal as fat, lean group) or a high-fat
diet (60kcal as fat, obese group) for 12 consecutive weeks. To detect the MIF expression and AMPK
activation in response to I/R in isolated hearts from lean and obese mice, myocardial samples were
collected from left ventricular areas at different time points. To determine whether MIF supplementation
is protective against I/R injury, recombined MIF (10 ng/mL) was applied before ischemia. Myocardial
infarct size was estimated by triphenyltetrazolium staining. Western blot was used to detect
myocardial MIF expression, AMPK activation and membrane glucose transporter 4 (Glut4) expression.

Results:

The expression of MIF was remarkably higher in obese group compared to lean group.
Ischemia increased myocardial MIF expression and phosphorylation of AMPK in lean mice, whereas it
had no significant effect on obese mice. Furthermore, administration of recombinant MIF increased
ischemic AMPK activation and membrane Glut4 expression in both lean and obese mice, while it reduced
the infarct size in lean mice only.

Conclusion:

An impaired MIF/AMPK activation response and consequent reduced membrane Glut4
expression may play an important role in increasing myocardial susceptibility to I/R in obesity.
Long-term Outcomes in Peripartum Cardiomyopathy
Authors: Mahowald Madeline K , Basu Nivedita , Subramaniam Latha , Scott Ryan , Davis Melinda B.
Published: March 2019

Background:

Prior studies of Peripartum Cardiomyopathy (PPCM) are limited by short-term follow-up. Contemporary long-term outcomes and change in myocardial function over time are poorly characterized.

Methods and Results:

This retrospective cohort study included women with PPCM at the University of Michigan (2000-2011), with follow-up on March 31, 2017. Subsequent pregnancies were excluded. Recovery was sustained left ventricular Ejection Fraction (EF) ≥55%. Major Adverse Events (MAE) included death, cardiac transplantation, left ventricular assist device, or inotrope-dependence. A total of 59 women were included (mean [SD] age at diagnosis, 29.5 [6.8]; 28.8% Black), with a mean follow-up of 6.3 years. Recovery occurred in 22 women (37%); of these, 8 women (36%) had delayed recovery (>12 months). All cause mortality was 20% (12/59) with median survival 4.2 years; of these, 9 women (75%) died after the first year (range 2 - 10 years). MAE occurred in 19 women (32%); of these, 11 women (42%) had MAE >12 months from time of diagnosis (range 2-20 years). Deterioration in EF by >10% from the time of diagnosis occurred in 16 women (27%). This group had worse long-term outcomes, including lower final EF (mean 25 vs 42%, p=0.010), less recovery (12 vs 46%, p=0.016), and higher rates of death (38 vs 14%, p=0.046) and MAE (56 vs 23%, p=0.016).

Conclusion:

Women with PPCM have long-term risks of mortality, MAE, and subsequent decline in EF, even in the absence of a subsequent pregnancy. Deterioration in EF is associated with adverse events; thus, long-term management is important.
Detection of OXA Beta Lactamases Among Clinical Isolates of Acinetobacter baumannii Isolated from Tehran Hospitals, Iran
Authors: Ranjbar Reza , Zayeri Shahin , Afshar Davoud , Farshad Shohreh
Published: March 2019

Background and Objective:

Acinetobacter baumanniiis a non-motile Gram-negative bacterial pathogen with the history of vast resistant to antibiotics. The aim of this study was to determine the possibility of existence of OXAs genes among clinical isolates ofA. baumanniiobtained from Tehran hospitals.

Materials and Methods:

A total of 101 isolates were identified asA. baumanniiby common biochemical and molecular tests. The susceptibility to different antibiotics was assessed with Kirby-Bauer disk diffusion method. Phenotypic Detection of MBLs was performed with CDT test and PCR assay was also performed for detection ofblaOXA-23-like,blaOXA-24-like,blaOXA-40-like,blaOXA-51-like,blaOXA-58-likeandblaOXA-143-likegenes

Results:

All isolates ofA. baumanniishowed high-level of resistance to all antibiotics except for Polymyxin B. TheblaOXA-51 likegenes was found in all of the isolates and the prevalence ofblaOXA-143like,blaOXA-23like,blaOXA-40likeandblaOXA-24likewere 56%, 45.45%, 33% and 11.8%, respectively.

Conclusion:

TheblaOXA-51-likewas the predominant mechanism of resistance to imipenem inA. baumanniiand therefore, early recognition of carbapenem-resistantA. baumanniiisolates is a useful tools to prevent their spreading within the hospital environment.
Heart Rate Measures From Wrist-Worn Activity Trackers in a Laboratory and Free-Living Setting: Validation Study (Preprint)
Authors: Müller Andre Matthias , Wang Nan Xin , Yao Jiali , Tan Chuen Seng , Low Ivan Cherh Chiet , Lim Nicole , Tan Jeremy , Tan Agnes , Müller-Riemenschneider Falk
Published: March 2019

BACKGROUND

Wrist-worn activity trackers are popular, and an increasing number of these devices are equipped with heart rate (HR) measurement capabilities. However, the validity of HR data obtained from such trackers has not been thoroughly assessed outside the laboratory setting.

OBJECTIVE

This study aimed to investigate the validity of HR measures of a high-cost consumer-based tracker (Polar A370) and a low-cost tracker (Tempo HR) in the laboratory and free-living settings.

METHODS

Participants underwent a laboratory-based cycling protocol while wearing the two trackers and the chest-strapped Polar H10, which acted as criterion. Participants also wore the devices throughout the waking hours of the following day during which they were required to conduct at least one 10-min bout of moderate-to-vigorous physical activity (MVPA) to ensure variability in the HR signal. We extracted 10-second values from all devices and time-matched HR data from the trackers with those from the Polar H10. We calculated intraclass correlation coefficients (ICCs), mean absolute errors, and mean absolute percentage errors (MAPEs) between the criterion and the trackers. We constructed decile plots that compared HR data from Tempo HR and Polar A370 with criterion measures across intensity deciles. We investigated how many HR data points within the MVPA zone (≥64% of maximum HR) were detected by the trackers.

RESULTS

Of the 57 people screened, 55 joined the study (mean age 30.5 [SD 9.8] years). Tempo HR showed moderate agreement and large errors (laboratory: ICC 0.51 and MAPE 13.00%; free-living: ICC 0.71 and MAPE 10.20%). Polar A370 showed moderate-to-strong agreement and small errors (laboratory: ICC 0.73 and MAPE 6.40%; free-living: ICC 0.83 and MAPE 7.10%). Decile plots indicated increasing differences between Tempo HR and the criterion as HRs increased. Such trend was less pronounced when considering the Polar A370 HR data. Tempo HR identified 62.13% (1872/3013) and 54.27% (5717/10,535) of all MVPA time points in the laboratory phase and free-living phase, respectively. Polar A370 detected 81.09% (2273/2803) and 83.55% (9323/11,158) of all MVPA time points in the laboratory phase and free-living phase, respectively.

CONCLUSIONS

HR data from the examined wrist-worn trackers were reasonably accurate in both the settings, with the Polar A370 showing stronger agreement with the Polar H10 and smaller errors. Inaccuracies increased with increasing HRs; this was pronounced for Tempo HR.
The Concordance Study between IBM Watson for Oncology and Multidisciplinary Team in Clinical Decision-making of Gastric Cancer and the Prognostic Implication (Preprint)
Authors: Tian Yulong , Liu Xiaodong , Wang Zixuan , Cao Shougen , Ji Qinglian , Liu Zimin , Li Zequn , Sun Yuqi , Zhou Xin , Wang Daosheng , Zhou Yanbing
Published: March 2019

BACKGROUND

With the increasingly abundant of cancer treatment, the emergence of multidisciplinary team (MDT) will provide patients with personalized treatment options. In recent years, artificial intelligence has developed rapidly in the medical field. And there is a tendency to replace traditional diagnosis and treatment gradually. IBM Watson for Oncology (WFO) has been proven in breast cancer and lung cancer, but the research on gastric cancer is rarely so far.

OBJECTIVE

Compared the concordance of WFO with that of MDT, and we try to investigate the patients' prognosis between them.

METHODS

This study retrospectively analyzed the eligible cases (N=235) of MDT with gastric cancer who received the corresponding treatment and obtained follow-up. Then doctors input the information of all cases into WFO manually, and the results was compared with the treatment programs by MDT. If the treatment program of MDT is classified as “recommended” or “considered”, we define the results as concordant. All patients were divided into concordant group and non-concordant group according to whether the treatment program of WFO and MDT were concordant. The prognostic analysis of the two groups was analyzed.

RESULTS

The overall concordance of WFO and MDT was 54.5% (128/235) in all 235 cases included in the study. Subgroup analysis found that patients with human epidermal growth factor receptor 2 (HER2)-positive were less likely to be concordant than patients with HER2-negative (P=0.019). Age, Eastern Cooperative Oncology Group performance status, differentiation type and clinical stage was not found to affect concordance. In all patients, the survival time of concordant patients were significantly better than that of non-concordant patients (P<0.001). Multivariate analysis revealed that consistency was an independent prognostic factor of overall survival in patients with gastric cancer (HR=0.312, 95% CI: 0.187-0.521).

CONCLUSIONS

Treatment recommendations made by WFO and MDT were mostly concordant for gastric cancer cases. If they can include the local treatment programs, the concordance will be significantly improved. The HER2 status of gastric cancer have a significant effect on concordance. Generally speaking, patients with concordant treatment programs had quite better survival than non-concordant patients.
Feasibility study of “BENECA mHealth”: a mobile system to improve quality of life via energy balance in breast cancer survivors (Preprint)
Authors: Lozano-Lozano Mario , Cantarero-Villanueva Irene , Martin-Martin Lydia , Galiano-Castillo Noelia , Sanchez Maria-José , Fernández-Lao Carolina , Postigo-Martin Paula , Arroyo-Morales Manuel
Published: March 2019

BACKGROUND

Energy balance is defined as the difference between energy expenditure and energy intake. The current state of knowledge supports the need to better integrate mechanistic approaches through effective studies of energy balance in cancer population, due to it is observed a significant lack of adherence to healthy lifestyle recommendations. In an attempt to stimulate changes in breast cancer survivors (BCS) lifestyles based on energy balance, our group developed BENECA mHealth application, which has been previously validated as a reliable energy balance monitoring system.

OBJECTIVE

Based on our previous results, the goal of this study was to investigate the feasibility of BENECA mHealth in an ecological clinical setting with breast cancer survivors, studying (1) its feasibility; and (2) pretest-posttest differences with regard to BCS’ lifestyles, quality of life (QoL), and physical activity (PA) motivation.

METHODS

Eighty BCS were enrolled in this prospective test-retest quasi-experimental study diagnosed with stage I to IIIA and with a body mass index over 25 kg/m2. Patients had to use BENECA mHealth for 8 weeks and were assessed at baseline and post-intervention period. Feasibility main outcomes included percentage of adoption, usage and attrition, user app-quality perception measured with the Mobile App Rating Scale (MARS), satisfaction with Net Promoter Score (NPS), and barriers and facilitators of its use. Clinical main outcomes included quality of life measure with EORT QLQ-C30, PA assess with accelerometry, PA motivation measure with the self-efficacy scale for physical activity (EAF), and body composition with a Dual-energy X-ray absorptiometry. Statistical (paired-sample t-tests was used) and Kaplan-Meier survival curve were analyzed.

RESULTS

BENECA was considered feasible by the BCS, in terms of use (76.3%; 58/76 BCS) adoption (69%; 80/116), and satisfaction (positive NPS). App quality score did not make it one of the best rated apps (3.71 ± 0.47 points out of 5). BENECA mHealth seems to improve the QoL of BCSs (global health mean difference (MD) 12.83, 95% CI 8.95–16.71, p<.001), as well as EAF score (global MD 36.99, 95% CI 25.52 – 48.46, p<.001), daily moderate-to-vigorous PA (MD 7.38, 95% CI 14.37–0.39, p=.039) and reduce body weight (MD -1.42, 95% CI -1.97 – -0.87, p<.001).

CONCLUSIONS

BENECA mHealth can be considered feasible in a real clinical context for being able to promote behavioral changes in the lifestyles of BCSs, but it needs to be optimized to improve user satisfaction with use and functionality. This study highlights the importance of the use of mobile applications based on energy balance and how the QoL of BCSs can be improved via monitoring.
Pengaruh Persepsi Label Halal Terhadap Preferensi Konsumen pada Restoran Pizza Hut dan KFC di Yogyakarta
Authors: Dewi Samad Telsy Fratama
Published: March 2019

Halal label has an important role to make consumers recognize easily the quality of products, especially to Muslim consumers. It has enhanced the image of products’s cleaness, purity, and no harm. The non-Muslims are also give positif feedback about halal label. This study aims to determine the consumers’ perseption of halal label, the effect perception of halal label on consumers purchasing preference at the Pizza Hut and KFC Restaurant. Determine whether there are differences in consumers' perception of halal label based on gender, religion, educational background, and income. Determine whether there are differences of influence on halal label perception based on gender, religion, education background and income to consumer preferences. This research is quantitative with 200 sample respondents Pizza Hut and KFC, simple random sampling method. The data collection using a likert scale questionaire. Data were analized using Correlation Analysis, Different T-test & F-test (Anova), and Analisis Multivariat Analysis Varians (Manova). The result found that overall average level of respondents's perception of halal label positif and has significant effect on the preferences. Then the result of analysis differences perseption found that there are significant differences between the consumers’ perseption of halal label based on gender, religion, educational background, while based income level, did not occur significantly different. The result analysis in effect, discover that there were significant differences influent perception of halal label on the characteristics of the consumers purchasing preferences: gender, religion, educational background, and income.
“Within the Thinking Worlds”: Feedback on “Bi-, Poly-, Translingualism and Language Education”. 2018. Moscow: PFUR. 448 p
Authors: Kulieva Sheker A
Published: March 2019

This review is a response to the collection of materials of the Conference “Bi-, Poly-, Translingualism and Language Education”, held in Moscow on December 7-8, 2018. The author gives a brief analysis of the main theoretical works of the Proceedings and tries to derive the main scientific trends identified in the process of the speakers’ presentations.
Transculturation of the Hero in G. Belger’s Novel “The Home of the Wanderer”
Authors: Demchenko Alena S
Published: March 2019

Using the methods of literary analysis, the author tries to trace the evolution of the hero of the novel by G. Belger in the aspect of the transcultural approach. The central object of the study was the “House” archetype. The author comes to the conclusion that the elements of different levels associated with this archetype - from ontological categories (“here-being”, “there-being”) to symbols allow explicating Belger’s idea of Allness, which serves as an alternative to Homelessness and Findability.
Iniciális tesztek mint a tanulói teljesítményt prognosztizáló eszközök
Authors: Kovács Elvira , Major Lenke , Námesztovszki Zsolt , Kovács Cintia , Karuović Dijana
Published: March 2019

Az online tesztelés új perspektívát kínál a pedagógiai értékelés folyamatában, növelve az elvégezhető vizsgálatok és a vizsgálható személyek számát. Kutatásunkkal arra a kérdésre kerestük a választ, hogy előrevetíthető-e a tanulói teljesítmény offline környezetben iniciális online tesztek segítségével. A kutatást az Újvidéki Egyetem Magyar Tannyelvű Tanítóképző Karának elsőéves hallgatói körében végeztük el, mintánkat az adott tanévre beiratkozott összes első évfolyamos hallgató képezte (N=134). A felmérés konkrét feladata volt kideríteni, hogy a digitális generációk oktatásában a röpdolgozatok mintájára alkalmazott, online összefoglaló tesztekkel mért eredmények előrevetítik-e a tanulók félév végi, papíralapú tesztekkel mért teljesítményét. A kutatás eredményeként megállapítható többek között, hogy a hallgatók ingadozó teljesítményt nyújtottak az előteszteken, nem fejlődtek fokozatosan, viszont mindhárom vizsgált tanévben magasabb eredményt értek el a félév végén megírt záróvizsgán, mint az előtesztek során. A tanulmányban részletesebben közölt eredményeink hozzájárulnak annak a feltevésnek a bizonyításához, miszerint az előteszteken elért eredmények segítenek előrevetíteni a záróvizsga eredményeit.

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Initial tests as students’ performance predicting equipment

The use of online testing provides a new perspective in the pedagogical evaluation process, increasing the number of people being tested and the number of examinations to be carried out. The aim of our research was to examine whether student performance could be predicted in an offline environment with initial online tests. The research was carried out among first-year students of the Hungarian Language Teacher Training Faculty of the University of Novi Sad. The sample consisted of the first-year students enrolled in the academic year courses (N=134). The specific goal of the survey was to study whether the results of the pop quizzes, which were evaluated with online summary tests, applied in the teaching of digital generations, and predicted the achievements measured with paper-based tests. On the basis of the research it can be claimed that the performance of the students fluctuated in the pre-tests and did not progress gradually. However, they achieved higher scores in the final test than in the pre-tests. Our results contribute to confirming the hypothesis that the students’ achievements in the pre-tests help predict those of the final tests.

Keywords: ICT tools, online test, pedagogical evaluation, student performance
The British Adriatic Squadron and the evacuation of Serbs from the Albanian coast 1915-1916
Authors: Kovic Milos
Published: March 2019

Unpublished sources and archival material can still shed fresh light upon the
history of the evacuation of the Serbian Army and civilian refugees from the
Albanian coast in 1915-1916. Among them are reports to the British Admiralty
written in 1915 and 1916 by the commander of the British Adriatic Squadron,
Rear Admiral Cecil Fiennes Thursby. These documents deposited in the
National Archives in Kew Gardens have never been used in reconstructing the
evacuation operation. Written on an almost daily basis, Thursby?s reports of
1915 and 1916 constitute a unique source not only for the history of the
evacuation of Serbs but also for the history of the South-East Europe in the
Great War.
German propaganda in the Balkans during the First World War
Authors: Dordanas Stratos
Published: March 2019

Immediately after the outbreak of the First World War Germany mobilized
hu?man resources from all fields and put up all the necessary funds to
counter British and French propaganda. In a very short period of time, it
was in a position to organize its own propaganda networks abroad, to a large
extent, by using the respective commercial networks and the pre-war
enterprises operating in various countries. It was the neutral countries
around the world that were among the primary targets of German propaganda.
In the Balkans particular effort was made to create a favourable climate for
the Central Powers and prevail over the adverse British and French
influence. With the assistance of commercial circles and the appropriation
of large sums of money, newspapers, journalists and publishing groups were
bought off, information offices set up, agents recruited, politi?cal parties
and politicians bribed, and pro-German parties founded. The aim was to
influ?ence public opinion, promote the German version of war developments,
and manipulate political leaders to give up their stance of neutrality and
make the decision for their coun?try to take part in the war on the side of
Germany. However, even though Berlin focused its attention on the Balkans
where the major propaganda networks were organized, the propaganda campaigns
proved to be essentially ineffective. Following Bulgaria?s entry into the
war on the side of the Central Powers and the destruction of Serbia, first
Romania and then Greece joined the Entente, finding themselves on the
winning side at the war?s end.
A ten years’ war aspects of the Greek historiography on the First World War
Authors: Michailidis Iakovos
Published: March 2019

This article tries to provide an evaluation of the Greek historiography on
the First World War (WWI) and to illustrate its various research stages and
trends. It is argued that the Greek historiography mainly approaches WWI and
Greece?s involvement not as an international, but as a domestic phenomenon.
Greek involvement in WWI has been looked at through the lens of the Asia
Minor Catastrophe in 1922, an episode of the ten-year war of the Greek army
starting with the triumphant Balkan Wars and ending with the defeat in the
Asia Minor Campaign in 1922.
What exactly did Romanian post-war nationalism mean?
Authors: Theodorescu Răzvan
Published: March 2019

In the last century nationalism as a spiritual element - according to the
1919 state?ment of the historian, archaeologist and philosopher Vasile
P?rvan - was a blessed plant grown on Romanian soil during the ?48
revolution, the ?59 union under Prince Cuza, the ?77 war of independence and
the preparation of such a national project as the Union with the Romanian
Kingdom of several Romanian-speaking provinces dominated by two em?pires -
the Austrian and the Russian - epitomized by Transylvania which came finally
to the motherland on the 1st of December 1918, the same day when the Kingdom
of Serbs, Croats and Slovenes was born. In the nationalism project, the
Union Transylvania was a political priority. But we must add immediately
that in the events of 1914-1916 in the neighbourhood of Romania a symbol of
the national struggle became what Nicolae Iorga, in a famous lecture of
1915, called ?the heroic and martyr Serbia?.
Turtucaia/Toutrakan 1916: La postérité d’une défaite dans la Roumanie de l’entre-deux-guerres
Authors: Ţurcanu Florin
Published: March 2019

La d?faite subie ? Turtucaia, la t?te de pont roumaine sur la rive sud de
Danube, en septembre 1916, a laiss? une marque ind?l?bile dans l?opinion
publique roumaine dans l?entre-deux-guerres. Les tentatives d?expliquer
cette d?faite sans appel au tout debout de l?engagement roumain dans la
Grande guerre se succ?daient en ajoutant son lot de rumeurs sur les
atrocit?s commises par les troupes bulgares victorieuses. La question de la
responsabilit? pour la d?faite fut une question brulante aux niveaux
politique et militaire d?j? pendant la guerre et notamment apr?s les retours
des officiers et soldats roumains apr?s la signature de la paix s?par?e en
mai 1918. La victoire et la cr?ation de la Grande Roumaine cr?a les
conditions pour les enqu?tes officielles, mais aussi pour la transposition
du sujet dans la litt?rature, t?moignage poignant de son importance et de
son actualit?. D?faite embl?matique et difficile ? ?vacuer de la m?moire
collective, d?faite porteuse d?un permanent avertissement sur la fragilit?
de la victoire finale et de ses acquis, d?faite convertible en r?quisitoire
sur une sc?ne politique en pleine transformation ? partir de 1918,
Turtucaia, ne devait s?effacer de la conscience publique roumaine qu?apr?s
l?instauration du communisme.
Heritage and memory of the First World War in Greece during the interwar period a historical perspective
Authors: Lemonidou Elli
Published: March 2019

The memory of the First World War in Greece has suffered throughout the years
a gradual decline, which is comparable to the case of many other countries,
mostly in areas of Eastern and Southeastern Europe. The Great War mattered
somehow for politicians, the press and public opinion in Greece only in the
interwar years. During that period, discourse about the First World War
included the echo of traumatic events related to Greek involvement in the
war(such as the surrender of Fort Roupel to Central Powers forces and the
bloody clashes of December 1916 in Athens after the landing of Entente
troops) and the efforts to erect war memorials as a tribute to the sacrifice
of fallen soldiers, both Greeks and foreigners. At the same time, the Greek
people had the opportunity to learn a lot about the international dimension
of the war through news?papers, where translated memoirs of leading wartime
figures (of both alliances) were published. After the outbreak of the Second
World War, interest in the previous major conflict (including the Greek role
in the hostilities) significantly diminished in the country. Taking into
consideration the ongoing experience of the centenary manifestations, the
author proposes a codification of the main types (existing or potential) of
WWI memory in Greece and suggests new ways of approaching this major
historical event. The final chapter addresses some possible causes of the
troublesome relation of Greeks with the First World War, which is mainly due
to the very particular circumstances of Greek involvement in the war and the
determining role of later historical events that overshadowed memories of
the earlier conflict.
Du traumatisme au roman. Mémoire et représentation de la Grande Guerre dans l’oeuvre de Rastko Petrovic (1898-1949)
Authors: Dusanic Dunja
Published: March 2019

Cet article se penche sur la relation entre la m?moire de la Grande Guerre
dans la culture serbe et sa repr?sentation dans l?oeuvre de Rastko Petrovic.
Profond?ment marqu? par la guerre, mais surtout par les ?v?nements de la
retraite par l?Albanie, Petrovic a pass? presque toute sa vie ? essayer de
briser son silence initial et d?exprimer ce qu?il avait v?cu pendant l?hiver
1915. Partant d?un long po?me narratif, ? Le Grand compagnon ? (1926), en
passant par un roman court, Huit semaines (1935), jusqu?? son dernier
ouvrage, Le sixi?me jour (1955), une v?ritable fresque ?pique, l??criture de
Petrovic porte la double trace d?un travail de m?moire intime et d?une qu?te
artistique visant ? repr?senter un traumatisme ? la fois personnel et
collectif. En d?crivant les diff?rentes ?tapes de ce travail, j?essaierai de
d?montrer les aspects dans lesquelles il correspond aux repr?sentations
of?ficielles de 14-18, ainsi qu?? la m?moire collective de ce conflit.
DETERMINATION OF GROWTH KINETICS AND BIOCHEMICAL COMPOSITION OF Nitzschia palea (Kützing) W. Smith ISOLATED FROM FRESHWATER SOURCES IN TURKEY
Authors: YALÇIN DUYGU Dilek
Published: March 2019

This study was performed in order to bring out a detailed information on growth dynamics and biochemical determination of the diatom species Nitzschia palea (Kützing) W. Smith under batch culture conditions in order to pave the way for further studies. The study material was isolated from a fresh water sample collected from Ankara, Turkey. The diatoms were cultured in Allen medium for 168 hours and the growth dynamics were determined by cell density and dry weight analyses. Specific growth rate, duplication time of the culture and biochemical compositions were also investigated. Molecular characterization of the N. palea strain was performed by applying Fourier Transform Infrared Spectroscopy. The cell density and the dry biomass of the culture at the end of the 168 hours incubation period was determined as 2.0x106±1.0x105cells/mL and 0.212±0.041 g L-1, respectively. The algal specific growth rate was found as 0.010 h-1 at 96-h and the doubling time was calculated as 68 h-1. The protein content was measured as 41.21%, carbohydrate content as 21.74%, lipid content as 16.84% and ash content as 19.88%. These results indicated that N. palea may be used in different fields of industries, especially in biodiesel production.
Relationships between role overload and work engagement among employees
Authors: Kim Yukyeong , Lee Hyejeen , Park HyungIn
Published: March 2019

This study investigated the mechanisms of the relationships between role overload and three dimensions of work engagement. It was hypothesized that psychological detachment would mediate the relationship between role overload and work engagement, and the indirect effect of role overload on work engagement through psychological detachment would be conditional on job crafting and marital status. Consistent with our hypothesis, the moderating effect of job crafting on the relationship between role overload and psychological detachment was significant in a sample of 446 workers. That is, job crafting alleviated the negative impact of role overload on psychological detachment. The interaction between marital status and psychological detachment was also significant for vigor; however, the direction was different from what was expected. For the married, vigor was relatively constant regardless of the level of psychological detachment, but for the unmarried, the more the psychological detachment the lower the vigor. In addition, this difference was observed more for women than men. In case of women, marital status also moderated the relationship between psychological detachment and dedication. Although the direction was unexpected, there was a conditional indirect effect of role overload on vigor and dedication through psychological detachment depending on the level of job crafting and marital status combined with sex differences. There was no conditional indirect effect for absorption. Implications and limitations of this study, and future research directions were discussed.