bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving and expanding Medical Subject Headings (MeSH) during times of social change
Authors: Weeks Aidy , Fell Stephanie , Hoskins Katie
Published: December 2024

In the summer of 2020, the Latinx Caucus of the Medical Library Association focused on addressing bias in medical subject heading terminologies by establishing the Hispanic/Latinx Inclusive Terminologies Project. Two project teams were formed. The Medical Subject Headings (MeSH) Project Team’s objective was to recommend inclusive and expanded language within existing medical subject headings to better represent Hispanic/Latinx populations in the United States. From January 2021 to June 2021, the MeSH Project Team conducted a scoping assessment of Hispanic/Latinx terminologies from various sources. The scoping assessment included a review of federal sources, biomedical and health databases, style guides, social media, news articles, and academic literature to review the historical use of Hispanic and Latino and usage trends of gender-neutral terms like Latinx and Latine. In reviewing the scoping assessment and existing MeSH structure for Hispanic and Mexican Americans, the MeSH Project Team recommended two new MeSH terms, Latin Americans and Brazilian Americans, and additional entry terms for existing headings. Team recommendations were submitted to the United States National Library of Medicine (NLM) between June and October 2021. The team also contacted NLM's MeSH Division for guidance on the terms creation and submission process. By systematically evaluating various resources using a scoping assessment as the primary tool and reviewing gaps within medical subject headings, the MeSH Project Team members could propose four recommendations for enhancing Hispanic/Latinx terminologies and influencing changes to existing terms.
Clinical interrogation of TP53 aberrations and its impact on survival in patients with myeloid neoplasms
Authors: Senapati Jayastu , Loghavi Sanam , Garcia-Manero Guillermo , Tang Guillin , Kadia Tapan , Short Nicholas J. , Abbas Hussein A. , Arani Naszrin , DiNardo Courtney D. , Borthakur Gautam , Pemmaraju Naveen , Oran Betul , Shpall Elizabeth , Popat Uday , Champlin Richard , Pierce Sherry , Arora Sankalp , Issa Ghayas , Yilmaz Musa , Patel Keyur , Takahashi Koichi , Montalban-Bravo Guillermo , Hammond Danielle , Haddad Fadi G. , Ravandi Farhad , Kantarjian Hagop M. , Daver Naval G.
Published: December 2024

In myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with TP53 aberrations, dissecting the interaction amongst patient, disease and treatment factors are important for therapeutic decisions and prognostication. This retrospective analysis included patients with newly diagnosed MDS (>5% blasts) and AML with TP53 mutation(s) treated at MD Anderson Cancer Center. We factored patient age, TP53 aberration burden, therapy intensity and use of venetoclax in the AML subgroup, and allogeneic hematopoietic stem cell transplantation (HSCT) to interrogate outcomes. TP53 was annotated as high-risk (TP53HR) if >1 mutation, one mutation + allelic deletion or a single mutation with variant allele frequency (VAF) ≥40%; TP53 low risk (TP53LR) included a single TP53 mutation VAF
Acquired thrombotic thrombocytopenic purpura of unidentified pathophysiology in patients with severe disease: completing the landscape of thrombotic thrombocytopenic purpura
Authors: Joly Bérangère S. , Leclercq Mathilde , Benhamou Ygal , Veyradier Agnès , Coppo Paul
Published: December 2024

Not available.
La motivación y el desempeño laboral en los colaboradores de la Asociación de Servicios de Limpieza “Peninsulares Unidos ASOSERPEN”
Authors: Gallegos Quiroz Claribel Sthefanía , Loor Chávez Temístocles Deodato
Published: December 2024

Introducción: la motivación en las empresas es esencial para el rendimiento de los empleados y el logro de objetivos organizacionales. Un ambiente laboral motivador puede mejorar la productividad y la proactividad. Este estudio se enfoca en las actividades que realiza la Asociación de Servicios de Limpieza Peninsulares Unidos (ASOSERPEN) Santa Elena, en la cual se ha podido denotar que la motivación laboral está relacionada al desempeño de sus colaboradores, debido a la disminución en las contrataciones y a la falta de incentivos, se ha observado una notable desmotivación en los empleados, lo que afecta su productividad, por ende, la competitividad de la empresa. Objetivos: Evaluar la motivación y la incidencia en el desempeño laboral en los colaboradores de la Asociación de Servicios de Limpieza Peninsulares Unidos ASORPEN Santa Elena   Metodología: esta investigación, es un estudio no experimental de corte transversal, enfocado en la motivación y desempeño laboral en ASOSERPEN. Se utilizó un enfoque cuali-cuantitativo y exploratorio, basado en datos y estudios previos. Se aplicó encuestas y entrevistas a 12 socios y 3 directivos, usando un muestreo no probabilístico. Resultados: en los resultados, se evidenció la necesidad de que exista una línea de comunicación oportuna, además de promover el incentivo y el reconocimiento en los socios, y por último, fortalecer las gestiones en la contratación pública para que ellos puedan abrirse a otros mercados. Conclusiones: en conclusión, es importante que el directorio mantenga siempre una capacitación en las áreas donde se desarrollen los socios y no desestimar el reconocimiento oportuno de acuerdo con su desempeño laboral. Área de estudio general: Gestión de Talento Humano. Área de estudio específica: Talento Humano. Tipo de artículo: Original.
Contamination of Street Vended, Ready to Eat Vegetable Salad with Multidrug Resistant Bacteria
Authors: Saheed Adedeji Abdulameen , Bisola Ray Sarah , Mcgandy Osula Godfirst , Adabara Nasiru Usman , Sadiq Fawziyyah Uman , Adamu Binta Buba , Kuta Faruk Adamu
Published: December 2024

Background: Street vended, ready to eat vegetable salads are consumed raw, often without heat treatment. Consequently, understanding their role in the spread of antibiotic resistant bacteria cannot be overemphasized. Objective: To study microbiological quality of street vended, vegetable salads sold in Minna metropolis in Nigeria. Materials and Methods: Fourteen (14) vegetable salads were sampled randomly in duplicates from street venders within Minna metropolis between June 2019 to November 2019. These samples were examined for the presence of bacterial isolates using standard cultural methods. Antibiotic susceptibility testing of the bacterial isolates was achieved by the disk diffusion technique. Results: Result analysis revealed 1.06 × 107 cfu/g mean total viable bacterial count. Similarly, the mean total coliform bacterial count was 0.94 × 107 cfu/g. The study revealed that all the sampled vegetable salads contained four or more bacteria. Staphylococcus aureus was the most frequent (19.5%), followed by Shigella and Klebsiella sp., (12.2%). However, E. coli, E. faecalis and Enterobacter sp. were less frequent (2.4%). The isolated Gramnegative bacteria exhibited resistance (≥ 73%) to amoxicillin/clavulanate, gentamicin, ofloxacin, cefuroxime and ampicillin. Furthermore, the isolated Gram-positive bacteria showed resistance to cefuroxime, ceftriaxone and amoxicillin/clavulanate in ≥ 40% cases. Multidrug resistant bacteria were 97.6% (40/41), of which 61.0% (25/41) was resistant to four or more antibiotics and have Multiple Antibiotic Resistance Index (MARI) ranging from 0.5 to 1.0. Conclusion: The results of this study show that street vended, ready to eat vegetable salad facilitates the transmission of clinically relevant antibiotic resistant bacteria. Therefore, appropriate measure should be enforced to ascertain the wholesomeness of street vended, ready to eat vegetable salad as the spread of the bacteria contaminant to humans by ingestion cannot be dismissed.
J Enam Med Col 2021; 11(3): 164-172
Posterior Reversible Encephalopathy Syndrome in a 20-Year-Old Female Admitted into the Intensive Care Unit
Authors: Khanum Easnem , Rahman Nelufa Tahera , Islam Ashraful , Rahman Towhidur , Mahmud Nahin , Begum Sheuly
Published: December 2024

Posterior Reversible Encephalopathy Syndrome (PRES) is a rare clinico-neuroradiological syndrome. Here we present a case of a 20-year-old lady who was admitted into our Intensive Care Unit (ICU) with respiratory distress, limb weakness, blurring of vision, four episodes of generalized tonic-clonic seizures, altered sensorium and headache on the14th day following Lower Segment Caesarian Section (LSCS) due to 38 weeks of pregnancy with severe pre-eclamptic toxaemia (PET). She was diagnosed as a case of PRES based on the clinical features along with findings on Magnetic Resonance Imaging (MRI). She was treated conservatively. Clinical condition of the patient was improved within 3 days. So, we conclude early recognition and proper management helps to reduce permanent neurological damage and thereby reduce morbidity and mortality.
J Enam Med Col 2021; 11(2): 190−194
From the desk of Editor-in-Chief
Authors: Khan Md Aminul Haque
Published: December 2024

Abstract not available
J Enam Med Col 2021; 11(3): 139
Student’s Perspective Towards Online Teaching-Learning Activity
Authors: Ahmed Mejbah Uddin , Roy Sushmita , Mahtab Uddin Bhuiyan Mohammad
Published: December 2024

Background: Online learning is a form of education that takes place over the Internet. With the advancement of information and communication technologies, the acceptance of online education is increasing. It is an alternative to traditional classroom learning and involves using primarily the internet and one or more other technologies. Objective: To identify the advantages and disadvantages of online learning from the student’s perspective. Materials and Methods: Data were collected from 256 MBBS students of Enam Medical College with a predesigned questionnaire by purposive sampling to assess the student’s perception towards the online teaching-learning modalities, its advantages, limitations and recommendations how the online teaching and learning process can be made more effective.  Results: The findings of the study revealed that most of the students are self-educated and lack of institutional knowledge regarding ICT tools and online learning process. The study result showed several advantages including; it is flexible regarding the time and place, sharing of information is easy and cost effective. Whereas, lack of face-to-face interaction, less effective in practice-based learning, disturbance of physical health, lack in student feedback, reliable internet connection, lack in computer skills and limited infrastructure at work place are identified as challenges. The students have also given their opinion regarding the possible steps and strategies to improve the online learning more effective. Conclusion: As with most teaching methods, online learning also has its own set of positives and negatives. Several initiatives like; more communication between students and teachers, use of more suitable technology, supporting the struggling students and creating a sense of comfort can make it more effective.
J Enam Med Col 2022; 12(1): 17−23
Expression of AgNOR in Benign, Borderline and Malignant Epithelial Tumors of Ovary and Its Correlation with Tumor Grading
Authors: Pervin Maksuda , Islam Nasimul , Kabir Enamul , Shirin Afroz
Published: December 2024

Background: Surface epithelial tumor is the most common type of ovarian tumor making up 65% of all ovarian neoplasms. The proliferative activity of tumor can be estimated by many methods and the analysis of silver binding nucleolar organizer region (AgNOR) is one of them. Two types of AgNOR counts were calculated – mAgNOR and pAgNOR. Objective: To find out expression of AgNOR staining in benign, borderline and malignant epithelial tumors of ovary and its correlation with tumor grading. Materials and Methods: This cross-sectional study was conducted in the department of Pathology, Sir Salimullah Medical College, Dhaka from March 2018 to July 2020. In this study 70 diagnosed cases of benign, borderline and malignant epithelial tumors of ovary were enrolled. Corresponding paraffin blocks were collected. Ethical practice was ensured in every step of the study. Statistical analysis was carried out as required. Statistical significance was considered at <0.05. Results: Most of the patients were in 31−40 years age group. Most commonly observed epithelial tumors were benign in nature followed by malignant tumors and only two cases were borderline. The mean mAgNOR in malignant tumors was 3.62±0.57, with benign tumors was 1.68±0.53 and with borderline tumors was 1.65±0.21. Progressive increase in AgNOR expression was noted from benign to malignant epithelial ovarian tumors. The mean mAgNOR found in Grade I, Grade II and Grade III were 3.29±0.37, 3.76±0.59 and 4.33±0.15 respectively. Significant differences were found among the all groups and when compared between Grade I and Grade II, also between Grade I and Grade III. The mean pAgNOR found in Grade I, Grade II and Grade III were 13.54±3.05, 16.19±4.35 and 21.33±1.15 respectively. Significant differences were found among the groups and also when compared between Grade I and Grade III. There was significant positive correlation between histological grading of ovarian tumor with mAgNOR (r=0.589; p=0.001) and with pAgNOR (r=0.510; p=0.003). Conclusion: mAgNOR and pAgNOR expressions were significantly elevated in malignant tumors compared to benign and borderline tumors. mAgNOR and pAgNOR are useful markers of cellular kinetics and good prognostic factors in epithelial tumors of ovary.
J Enam Med Col 2022; 12(1): 29−35
Dyslipidemia in Pregnancy-Induced Hypertension
Authors: Mohtarin Sabreena
Published: December 2024

Pregnancy-induced hypertension (PIH) is a leading cause of maternal mortality and morbidity. Abnormal lipid profile and increased lipid peroxidation activate endothelial dysfunction causing PIH. Estimation of lipid profile in pregnancy may be helpful in predicting the development of PIH and further progression. Early diagnosis of dyslipidemia may prevent PIH thereby preventing obstetric complications. Dyslipidemia is known to be associated with essential hypertension but their role in PIH remains unclear. Early identification of at-risk women may help in taking timely preventive and curative management to prevent pregnancy related complications.
J Enam Med Col 2022; 12(1): 50−53
Surgical Management of Zygomatico-Maxillary Complex Fractures in Enam Medical College Hospital, Savar: A Retrospective Study of 70 Cases
Authors: Abdullah Al Faruq  , Manjur-E-Mahmud  , Shakil Shahriar  , Sharmin Sultana
Published: December 2024

Background:  The incidence of maxillofacial injuries is on the rise due to motor vehicle accidents and increased incidence of violence in recent times. Zygomatic bone is closely associated with the maxilla, frontal, and temporal bones which are usually involved when a zygomatic bone fracture occurs. Objective:  The aim of this retrospective study was to determine clinical presentations, the pattern of fractures, their management (open reduction and internal fixation), outcome and complications in a tertiary level hospital. Materials and Methods: This retrospective analysis of all operative cases (open reduction and internal fixation) of zygomatic complex fractures was carried out in the Maxillofacial Surgery Department, Enam Medical College & Hospital, Savar, Dhaka during  the period of January 2018 to December 2021. Data were obtained from clinical notes and surgical records of the patients using standardized data collection form specifically designed to examine the variables and features of zygomatic complex fractures. Results: Seventy patients were allocated to surgical intervention. Two-point internal fixation was done in more than half (57.1%) of the cases. Six (8.6%) patients developed postoperative complications like paraesthesia, ectropion, scar, facial asymmetry. Twenty-five (35.7%) patients were found having limited mouth opening preoperatively and postoperative improvement occurred in 24 patients. All the patients had facial asymmetry preoperatively and postoperative improvement occurred in most cases. Only one patient had facial asymmetry in one year follow up. Conclusion: There is no consensus on standard treatment of zygomatic complex fractures, as made evident by the survey. Significant variability in fracture type warrants an individualized approach to management. A thorough review on zygomatic complex fracture management is provided.
J Enam Med Col 2022; 12(2): 102−108
Comparison between Laparoscopy and Laparotomy in the Management of Ectopic Pregnancy
Authors: Tania Akbar  , Sumia Bari  , Sheuly Begum  , Rina Nasrin  , Monowara Begum
Published: December 2024

Introduction: Ectopic pregnancy has become one of the most alarming causes of maternal mortality and morbidity and the number of maternal death due to ectopic pregnancy is also in increasing trend. Usually ruptured ectopic pregnancy is managed by laparotomy. But nowadays due to improved anesthesia and cardiovascular monitoring support together with advanced laparoscopic surgical skills and experience, operative laparoscopy for surgical management of ectopic pregnancy is justified, even in women with significant hemoperitoneum. Objectives: The aim of this study was to assess the clinical profile, risk factors and diagnostic modalities for ectopic pregnancy and to assess the operative findings, operative procedure and post-operative condition at laparoscopy and laparotomy cases. Materials and Methods: It was a cross-sectional study, conducted in the Department of Obstetrics & Gynecology in Enam Medical College & Hospital, Dhaka, Bangladesh. The study period was from July 2018 to July 2020. A total 72 patients were included for the study. All the patients were managed according to the hospital protocol. Data were analyzed by using Statistical Package for Social Sciences (SPSS) version 11.5. Results: A total of 72 cases were the study subjects. Laparotomy was done in 45 (62.5%) cases and laparoscopy in 27 (37.5%) cases. Most of the patients came with abdominal pain. Twenty seven patients (37.5%) who came with shock and all were managed by laparotomy. Commonest site of ectopic pregnancy was ampullary region －27 (37.5%) and were managed by laparotomy and 23 (31.94%) by laparoscopy. Most of the ectopic pregnancies were ruptured and 14 (19.44%) ruptured cases were managed laparoscopically. Hemoperitoneum (1000－2000 mL) was present in 25 cases, among them 7 (9.72%) were managed by laparoscopy. Salpingectomy was the commonest surgery－by laparoscopy 26 (36.11%) and by laparotomy 42 (58.38%). In laparotomy 32 (44.44%) cases and in laparoscopy 9 (12.5%) cases needed blood transfusion, which was comparatively less in laparoscopy. There was no wound infection in laparoscopy cases. Post-operative morbidity was also less in laparoscopy than in laparotomy. Conclusion: Ectopic pregnancy is considered as a life-threatening severe health condition and the number is dramatically increasing day by day. For the treatment of ectopic pregnancy, emergency intervention is must. Nowadays, laparoscopic management might be the most effective procedure with maximal safety and efficacy.
J Enam Med Col 2022; 12(2): 84−89
Lahjakkaat oppijat osana perusopetuksen inkluusiota: Opettajaopiskelijoiden käsityksiä
Authors: Lassila Erkki T. , Hyry-Beihammer Eeva Kaisa
Published: December 2024

Tutkimuksen tavoitteena on selvittää opettajaopiskelijoiden käsityksiä lahjakkaiden oppijoiden opettamisesta osana inklusiivisuutta painottavaa suomalaista perusopetusta. Opettaja opiskelijoille esitettiin skenaario kehyskertomuksena, jonka kirjoittamista he jatkoivat ohjeistuksen mukaan. Positioanalyysin ja laadullisen sisällönanalyysin avulla tarkasteltiin opiskelijoiden lahjakkaille oppijoille antamia positioita sekä perusteluja huomioida tai olla huomioimatta lahjakkaiden tarpeita opetuksessa ja muussa luokkahuonetoiminnassa. Kirjoitelmissa todettiin, että opettajan pitäisi toiminnassaan huomioida lahjakkaiden oppijoiden tarpeet, mutta samalla kuvattiin myös monenlaisia jännitteitä, jotka tekevät eriyttämisestä haasteellista. Perustelut kytkeytyivät ymmärrykseen 1) inkluusion pedagogisesta ulottuvuudesta, 2) inkluusion sosiaali-sesta ulottuvuudesta ja 3) opettajan professionaalisuuden ulottu-vuudesta. Lahjakkuuden tukeminen näyttäisi haastavan tulevia opettajia myös emotionaalisesti. Lahjakkuutta sekä siihen liittyviä käsityksiä ja tunteita on syytä käsitellä opettajankoulutuksessa, jotta tulevat opettajat pystyvät työssään huomioimaan lahjakkaiden opettamisen osana inkluusiota.
Inklusiivisen kasvatuksen teemojen käsittely opettajankouluttajien opetuksessa
Authors: Pulkkinen Jonna , Pirttimaa Raija , Viitala Riitta
Published: December 2024

Inklusiivisen kasvatuksen toteutuminen koulutuksessa edellyttää opettajilta monipuolista osaamista, mikä on huomioitava myös opettajankoulutuksessa. Tämä tutkimus tarkastelee, missä määrin opettajankouluttajat (N=142) käsittelevät omassa opetuksessaan inklusiivista kasvatusta ja millaisia eroja inklusiivisen kasvatuksen käsittelyssä on eri koulutusaloilla työskentelevien opettajan-kouluttajien välillä. Tutkimuksessa käytetyn kyselyn laadinnassa on hyödynnetty Euroopan erityisopetuksen kehittämiskeskuksen Osallistavan opettajan profiilia (Profile of inclusive teachers). Aineiston analysoinnissa käytettiin eksploratiivista faktorianalyysia ja yksisuuntaista varianssianalyysia (ANOVA). Inklusiivisiin ammatillisiin käytänteisiin ja inklusiivisiin opetuskäytänteisiin liittyvät teemat olivat opettajankoulutuksessa suhteellisen paljon esillä, kun taas inklusiivista kasvatusta edistäviä periaatteita käsiteltiin opettajankoulutuksessa vähemmän. Eniten inklusiivista kasvatusta käsittelivät omassa opetuksessaan erityisopettajien kouluttajat. Koska inklusiivinen kasvatus on osa jokaisen opettajan työtä, inklusiivisen kasvatuksen olisi tärkeää olla yhtäläisesti esillä kaikissa opettajankoulutuksissa. Erityisesti inkluusion perustelujen käsittelyyn olisi syytä kiinnittää opettajankoulutuksessa enemmän huomiota.
Faricimab versus the standard of care for neovascular age-related macular degeneration in Italy: an indirect treatment comparison
Authors: Galeone Carlotta , Turati Federica , Nicolò Massimo , Parravano Mariacristina , Vujosevic Stela , Bianchino Laura , Sicari Emilia , Lanzetta Paolo
Published: December 2024

Objectives: To assess through an indirect treatment comparison (ITC) the potential benefit of faricimab over the anti-vascular endothelial growth factor (VEGF) real-life scenario, hereby defined standard of care (SoC), in Italy, that is, aflibercept, bevacizumab, and ranibizumab, in patients with neovascular age-related macular degeneration (nAMD) naïve to any anti-VEGF treatment.
Methods: Individual patient-level data from the phase III clinical trials TENAYA and LUCERNE (faricimab cohort) and the real-world study RADIANCE (RADIANCE cohort) were used. Efficacy was evaluated with changes in best corrected visual acuity (BCVA) and central subfield thickness (CST) from baseline to 1 year (week 52 in the RADIANCE and week 48 in the faricimab cohorts, respectively). Propensity score-based inverse probability of treatment weighting was utilized to balance cohorts and mitigate bias due to potential confounding. Sensitivity analyses were performed to evaluate treatment differences adjusted for the number of injections.
Results: The ITC included 513 patients treated with faricimab and 263 patients treated with SoC. At 1 year, faricimab showed a greater mean BCVA gain (treatment difference +5.4 letters, p<0.001) and CST reduction (treatment difference −71.8 μm, p<0.001) compared to SoC. Sensitivity analyses confirmed the robustness of results, showing a BCVA improvement of +4.0 letters and a CST reduction of −71.5 μm in favor of faricimab.
Conclusions: Despite the limitations due to the use of ITC and the comparison between clinical trials and real-world cohorts, the present analysis suggests potential benefits in terms of vision gain and CST reduction in naïve nAMD patients treated with faricimab compared with SoC in a real-world setting.
CrossRef.org
Authors: Pater Ivan
Published: December 2024

The contribution of the activists of the Union of the Liberation of Ukraine to the

implementation of the national question in connection with European geopolitical re-
lations, their struggle for the revival of the independence of the Ukrainian state are

highlighted.
For sсientist, higher education teachers, students of humanitarian profile.
Dispositivos eletrônicos para fumar: Revisão crítica sobre os impactos na saúde pública
Authors: Pires Carla Vitória Carvalho , Macedo Louise Xavier , Ferreira Marcelo Vicente Munin , Carvalho Mayara Santos de Souza , Bezerra Ana Luiza Pereira , Lopes Francicero Rocha
Published: December 2024

Objetivo: Avaliar o impacto que os Dispositivos Eletrônicos para Fumar (DEFS), causam na saúde pública, explorando diversas especialidades médicas, (pneumologia, endocrinologia, oncologia, psiquiatria, cardiologia, vascular) e suas consequências nas mesmas. Metodologia: Este artigo é uma revisão integrativa da literatura seguindo etapas propostas por Mendes Silveira e Galvão (2008). A pesquisa foi realizada em bases de dados digitais, PubMed e SciELO, abrangendo os anos de 2021 a 2024, foram analisados 19 estudos relevantes. Resultados: Os resultados obtidos mostraram que os DEFS estão relacionados a diversos impactos negativos na saúde pública em diferentes especialidades médicas, as consequências mais vistas estão relacionadas ao sistema respiratório como dificuldades respiratórias e lesões pulmonares (EVALI). Conclusão: Embora vistos inicialmente como alternativas mais seguras quando comparados aos cigarros tradicionais, os dispositivos eletrônicos para fumar apresentam riscos significativos. As descobertas sobre seus impactos ressaltam a necessidade de políticas públicas rigorosas e campanhas de conscientização para minimizar seu uso e proteger a saúde pública.
Implementasi Moderasi Beragama dalam Hubungannya dengan Sesama Muslim
Authors: Utomo Budi , Ali Mudzakkir , Hamzah Ghufron
Published: December 2024

This article aims to determine the implementation of religious moderation in relations with fellow Muslims. The research used is a qualitative research method with a type of library data collection by reading books, journals or other sources that are believed to be true. Indonesia is a country consisting of many tribes, races and religions, of course this easily creates divisions. Many of the divisions themselves originate from liberal and extremist ideologies that have entered Indonesia. As a multicultural nation, Indonesia is very appropriate to practice moderation. A moderate, fair and balanced mental attitude is the main key in managing diversity. The results of this discussion show that the implementation of religious moderation in relations with fellow Muslims includes: 1) Brotherhood with fellow Muslims; 2) Say hello and pray for each other; 3) Advise others wisely; 4) Maintaining the honor of fellow Muslims; 5) Respect elders, love younger ones; 6) Mingling with members of the opposite sex who are not mahram; 7) Do not hurt Muslim feelings; 8) Help each other with the affairs of fellow Muslims.
Peran Kepemimpinan Kepala Sekolah dalam Mengembangkan Budaya Mutu Sekolah
Authors: Ismawiyah Ismawiyah , Anshari Muhammad Zulkifli , Aslamiah Aslamiah , Cinantya Celia , Azizah Fitria
Published: December 2024

Quality is the level of conformity of a product, service or work result based on standards that have been created. Quality can also be measured based on the ability of a product or service to meet the needs and expectations of users or consumers. Schools as educational service providers must guarantee quality on an ongoing basis. This needs to be supported by the formation of a quality culture in schools. A school quality culture is an important foundation in efforts to continuously improve the quality of education. In the educational context, a culture of quality includes a commitment to high standards in the teaching and learning process, school management, and achieving optimal results for all students. The principal as the main leader in the school has a very strategic role in building and developing this quality culture. The purpose of this writing is to describe the role of the principal in developing a quality culture in the school. This research method is a qualitative research method, data mining is carried out by reviewing literature (scientific articles, books and other supporting sources). The results of this research illustrate that a culture of quality can be built by optimizing the role of the school principal to the maximum, such as the role of the school as a leader. Apart from that, it also makes supervision more effective in the performance of teaching and educational staff.
PERANCANGAN WATER CHILLER PENGKONDISI MEDIA TANAM HIDROPONIK DEEP FLOW TECHNIQUE UNTUK TANAMAN SELADA (LACTUCA SATIVA)
Authors: Akbar Anas , Angin Ranufani Mahameru Timur , Arman Muhammad , Lukitobudi Arda Rahardja , Prasetyo Bowo Yuli
Published: December 2024

Saat ini keterbatasan lahan serta perubahan iklim yang ekstrem menyebabkan pertumbuhan tanaman menjadi kurang optimal. Pemanfaatan sistem hidroponik dengan air yang dikondisikan dapat menjadi salah satu solusi alternatif. Penelitian ini bertujuan untuk merancang dan menguji kinerja sistem water chiller sebagai pengkondisi media tanam selada hidroponik. Sistem water chiller dimanfaatkan untuk menyerap kalor pada air sehingga temperaturnya dapat dikondisikan sesuai dengan kondisi ideal tumbuh kembang tanaman. Air yang dikondiskan kemudian dimanfaatkan untuk pengkondisian media tanam selada hidroponik dengan metode deep flow technique (DFT). Dengan temperatur air yang dijaga pada rentang 15 hingga 20oC, diperoleh beban pendinginan sebesar 694,8 Watt. Sistem dibangun menggunakan sebuah condensing unit yang dilengkapi evaporator berjenis bare-tube yang ditempatkan pada cool box sebagai sarana pertukaran kalor dengan air. Hasil pengujian menunjukkan sistem yang dibangun mampu menurunkan temperatur air hingga 15.9oC dalam waktu 30 menit. Pengujian sistem menunjukkan perolehan Coefficient of Performance-actual (COPa) sebesar 4,05 dan Coefficient of Performance-carnot (COPC) sebesar 5,13, dengan efisiensi refrigerasi sebesar 78,98%. Hasil panen dari selada hidroponik memiliki massa 0,65 kg dengan lama penanaman 18 hari.
KUAT TEKAN BETON ROLLER COMPACTED CONCRETE (RCC)-FLY ASH 15% YANG DIRENDAM SODIUM SULFAT
Authors: Jodiansyah  , Sulistyorini Dewi , Gutama Detha Sekar Langit Wahyu
Published: December 2024

Perkerasan beton RCC merupakan perkerasan beton yang mempunyai daya tahan, bernilai ekonomis, umur lumayan panjang dan pemeliharaan rendah. Penelitian ini beton RCC dipadatkan dengan vibrator hammer sebanyak 3 lapisan dengan durasi waktu 20 detik/lapisan. Proporsi campuran berdasarkan SNI 03-2834-2000 dan modifikasi dari beberpa jurnal dengan rencana kuat tekan 25 MPa. Material yang digunakan adalah agregat kasar, agregat halus, semen Portland Composite Cemen (PCC), air, abu terbang (fly ash) dan superplasticizer (spc). Persentase fly ash yang digunakan dalam penelitian ini 15% dari berat semen dengan jumlah benda uji 12 buah. Pengujian kuat tekan beton silinder berdiameter 15 cm dan tinggi 30 cm dengan mengunakan dua variasi perendaman yaitu air biasa dan sodium sulfat (Na2So4), dua variasi durasi waktu yaitu 14 hari dan 28 hari. Hasil penelitian menunjukan kuat tekan beton RCC 15 B-14 diperoleh sebesar 49.16 MPa, RCC 15 B-28 sebesar 52.29 Mpa, RCC 15 S-14 sebesar 46.87 Mpa, dan RCC 15 S-28 sebesar 50.65 Mpa. Perendaman beton pada sodium sulfat selama 14 hari mengalami penurunan kuat tekan sebesar 4.7% dari perendaman air biasa, sedangkan perendaman beton pada sodium sulfat selama 28 hari mengalami penurunan kuat tekan sebesar 3.1% dari perendaman air biasa, namun demikian hasil kuat tekan masih melebihi kuat tekan rencana 25 MPa.
METODE PERKUATAN LERENG DI INDONESIA: SYSTEMATIC LITERATURE REVIEW
Authors: Mahfuzh Andika Syahal , Surjandari Niken Silmi
Published: December 2024

Lereng adalah permukaan tanah yang membentuk sudut tertentu terhadap bidang horisontal dan tidak terlindungi. Lereng membutuhkan perkuatan untuk mencegah kegagalan atau kelongsoran yang disebabkan oleh faktor manusia atau faktor kondisi alam. Perkuatan lereng berfungsi menjaga stabilitas dan meningkatkan faktor aman (safety factor) pada suatu lereng. Tujuan penelitian ini adalah mengetahui perkuatan lereng yang paling banyak digunakan di Indonesia. Metode yang digunakan yaitu Systematic Literature Review (SLR) dengan mengumpulkan 100 jurnal melalui Sinta, Scopus, dan Garuda, lalu dipilih berdasarkan tahapan yang sudah ditentukan yaitu Research Question, Search Proses, Inclusion and Exclusion Criteria, dan Quality Assesment. Hasil Penelitian menunjukan pada RQ1 perkuatan lereng yang paling banyak digunakan di Indonesia yaitu Dinding Penahan Tanah dengan persentase 29,87%, Soil Nailing 20,78%, Geosintetik 19,48%, Pile 16,88%, Tumbuhan/Vegetasi 5,19%, Counterweight 3,9%, Subdrain 2,6%, dan Model Scale Test With X-Block 1,3%.   Lalu, pada RQ2 menunjukan alasan penggunaan Dinding Penahan Tanah karena topografi Indonesia yang berbukit dan berlereng dengan derajat yang cukup besar atau curam, sehingga membuat lereng rentan terhadap erosi dan longsor. Pada RQ3 disampaikan implementasi perkuatan Dinding Penahan Tanah untuk solusi permasalahan lereng di Indonesia. Berdasarkan hasil systematic literatur review, dinding penahan tanah cocok dipakai di Indonesia dikarenakan dalam pembuatannya menggunakan material-material yang mudah didapat. Jadi, dalam perkuatan lereng di Indonesia direkomendasikan perkuatan menggunakan Dinding Penahan Tanah.
EVALUATION OF THE IMPACT OF CAPACITOR BANK CAPACITY ON ENERGY EFFICIENCY AND POWER FACTOR AT ASTON INN HOTEL TASIKMALAYA
Authors: Faridah Linda , Rivaldi Vadilah  , Usrah Ifkar
Published: December 2024

This study aims to evaluate the impact of capacitor bank capacity on energy efficiency and power factor at Aston Inn Hotel Tasikmalaya. The hotel's electrical system is characterized by a predominance of inductive loads, which generate a considerable amount of reactive power, thereby decreasing the overall power factor. To address this issue, capacitor banks are commonly used as a power factor correction tool, helping to reduce reactive power, minimize energy losses, and lower operational costs. However, the correct sizing of capacitor banks is crucial, as incorrect capacities can lead to system inefficiencies and potential instability. In systems where the power factor is low, there is an increase in electrical current, which contributes to higher energy losses in the form of heat and, consequently, elevated operational expenses. This study adopts a comprehensive approach involving direct measurement of the hotel's electrical system, detailed analysis of load data, and calculation of the ideal capacitor bank capacity required for optimal performance. The aim is not only to improve energy efficiency but also to enhance the overall stability and safety of the hotel's electrical network. The results of this research reveal that the currently installed capacitor bank has a capacity of 300 kVAr, which is significantly larger than the ideal requirement of 55 kVAr as determined through load analysis. This substantial excess in capacity results in a power factor shift from lagging to leading. Such a shift can lead to adverse effects on the electrical system, including potential instability, equipment malfunction, and increased wear and tear on system components. Additionally, it was discovered that the existing Power Factor Controller (PFC) is not operating at its optimal setting, further complicating the situation and preventing the system from achieving the desired power factor improvements. Based on these findings, it is recommended that adjustments be made to the capacitor bank capacity to align with the calculated ideal value. Moreover, a reconfiguration and proper tuning of the Power Factor Controller are necessary to ensure optimal performance. These corrective actions are expected to enhance power factor correction, improve energy efficiency, reduce operational costs, and maintain system stability within the hotel's electrical network.
Evaluating Diagnostic Performance of Extrapulmonary Tuberculosis Using Cartridge-Based Nucleic Acid Amplification Test Assay: A Retrospective Cross-Sectional Study at a Tertiary Health Care Setup in India
Authors: Kashyap Bineeta , Sarkar Krishna , LNU Sharanya , Banik Debamita , Hyanki Puneeta
Published: December 2024

Background: Extrapulmonary tuberculosis (EPTB) diagnosis is difficult due to its subclinical or nonspecific clinical symptoms, paucibacillary nature, and difficulties in obtaining qualified pathological specimens for Mycobacterium tuberculosis detection. Given the paucibacillary nature of EPTB, and drug resistance as high as 19%, rapid diagnostic methods like Xpert MTB/RIF (Cepheid, Sunnyvale, California, USA) can make a significant clinical impact. In this study, the authors aim to determine the positivity rate of Mycobacterium tuberculosis in EPTB samples by Xpert MTB/RIF or cartridge-based nucleic acid amplification test (CBNAAT) in a tertiary healthcare setup.

Materials and methods: This was a retrospective cross-sectional study where presumptive extrapulmonary cases of any age were considered for inclusion. A total of 688 suspected extrapulmonary samples were analysed by CBNAAT over a period of 7 months.

Result: A total of 25% (170/688) of the cases were reported to be positive, while the combined rate of Error, Invalid, and No result was 8.5% (59/688). Rifampicin resistance was seen in 14 isolates, while four isolates showed indeterminate results.

Conclusion: Varied clinical presentations and the paucibacillary nature of the extrapulmonary samples often lead to the failure of diagnosis by conventional diagnostic tests (smear microscopy and culture). Hence, molecular diagnostic techniques play a crucial role in rapid diagnosis. The present study thus highlights the impact of CBNAAT in the definite diagnosis of extrapulmonary tuberculosis in a tertiary healthcare centre.
Abdominal Cocoon and Recurrent Haemorrhagic Ascites, Unexpected Findings in Endometriosis: A Case Report and Review of Literature
Authors: Jamil Rosheen , Jamil Maheen
Published: December 2024

Introduction: The presentation of endometriosis as massive haemorrhagic ascites and the presence of concurrent encapsulating sclerosing peritonitis is extremely rare in medical literature. This presentation warrants a strong suspicion for endometriosis especially in a nulliparous, reproductive-age woman.

Case Report: A 22-year-old woman presenting with nonspecific abdominal discomfort, distension, massive ascites, dysmenorrhea, anaemia, and mild weight loss is reported here.

Diagnosis: Based on biopsy results at laparotomy, negative Tuberculosis cultures, a poor response to the anti-tuberculosis therapy, and, finally, an excellent response to combined oral contraceptive pills, endometriosis was confirmed as the diagnosis of exclusion in this case.

Interventions and outcomes: The patient received medical treatment for endometriosis and had an excellent response to treatment.

Methods: The team conducted a thorough literature review on PubMed/MEDLINE, Cochrane, and Science Direct and shortlisted 13 highly relevant articles for the case report. The patient provided informed written consent for the publication of this case report, with no patient-identifying information included in the article. The figures in the case report have not been published elsewhere, so the authors did not require copyright permission.

Conclusion: This is one of the few cases reported in the literature in which endometriosis presented with haemorrhagic ascites and sclerosing peritonitis. Endometriosis should be considered a differential diagnosis in a nulliparous, reproductive-age female who presents with massive recurrent haemorrhagic ascites.
Inclusión en Educación Física: explorando Actitudes y Competencia Social en Estudiantes de un centro preferente de atención al alumnado con necesidades educativas especiales
Authors: Martínez-Bañón Roxana , Abellán Jorge
Published: December 2024

Las actitudes hacia la discapacidad de los compañeros sin discapacidad son cruciales para la inclusión efectiva de estudiantes con discapacidad en las clases de Educación Física. Este estudio examina las actitudes hacia la discapacidad y la competencia social entre estudiantes de Educación Secundaria Obligatoria en un centro, analizando estas variables según sexo, curso y contacto previo con personas con discapacidad. Participaron 323 estudiantes (14,16 ± 1,33 años), evaluándose las actitudes mediante la escala de actitudes en Educación Física (Íñiguez-Santiago et al., 2017) y la competencia social mediante el Cuestionario Multidimensional de competencia social (Gómez-Ortíz et al., 2017). Se encontró una correlación positiva significativa entre ambas variables, indicando que una mayor competencia social se asocia con actitudes más positivas hacia la discapacidad en Educación Física. En cuanto a las diferencias por sexo, las chicas mostraron actitudes más positivas y una competencia social más alta. El contacto previo con personas con discapacidad también influyó positivamente en las actitudes y tuvo un efecto significativo en el Ajuste Normativo. Estos resultados sugieren la viabilidad de programas combinados para mejorar tanto las actitudes como la competencia social en Educación Física, promoviendo así la inclusión efectiva.
Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis
Authors: Li Jialin , Xiao Fang , Lin Bingsen , Huang Zhilei , Wu Mingyue , Ma Huan , Dou Ruoxu , Song Xiaodong , Wang Zhongxing , Cai Changjie , Guan Xiangdong , Xu Jie , Xiang Fu-Li
Published: December 2024

Introduction

Sepsis-induced cardiomyopathy is a common complication of sepsis and is associated with higher mortality. To date, effective diagnostic and management strategies are still lacking. Recent studies suggest that ferroptosis plays a critical role in sepsis-induced cardiomyopathy and ferroptosis inhibitor Ferrostatin-1 (Fer-1) improved cardiac dysfunction and survival in lipopolysaccharide (LPS) induced endotoxemia. However, the effects of Fer-1 in cardiac dysfunction in the early stages of cecal ligation and puncture (CLP) induced sepsis remains unclear. Our study aims to elucidate the role of Fer-1 in the acute phase of peritonitis sepsis induced cardiac injury.

Methods and Results

CLP was used to induce peritonitis sepsis in mice. Pretreatment of ferroptosis inhibitor ferrostatin-1 (Fer-1) was used in the in vivo models. Survival was monitored for 48h. Cardiac function and histology were analyzed 6h after surgery. We found that ejection fraction (EF) remained normal at 6h after CLP, but the contractility detected by cardiac muscle strain analysis was significantly reduced, along with increased immune cell infiltration. Pretreating the CLP mice with 5 mg/kg Fer-1 significantly reduced mortality. At 6h after CLP, ferroptosis key regulator Gpx4, cardiac iron and malonaldehyde (MDA) did not change, but ferroptosis marker gene expression increased. Fer-1 treatment showed beneficial effects in cardiac function, less myocardial inflammatory cytokine expression and significantly inhibited immune cells, especially neutrophil infiltration in the heart. Consistently, expression of neutrophil associated chemokines (Ccrl2, Cxcl2, Cxcl3 and Cxcl5) as well as extracellular matrix (ECM) degradation enzymes (Adamts1, Adamts4, Adamts9 and Mmp8) significantly decreased in Fer-1 pre-treated CLP heart.

Conclusion and Discussion

Our findings suggest that Fer-1 inhibits neutrophil infiltration in early sepsis by disrupting the chemokine axis, highlighting its potential as a therapeutic option to manage acute immune overactivation in early stages of sepsis-induced cardiomyopathy.
Identification of patients with unstable angina based on coronary CT angiography: the application of pericoronary adipose tissue radiomics
Authors: Zhan Weisheng , Li Yixin , Luo Hui , He Jiang , Long Jiao , Xu Yang , Yang Ying
Published: December 2024

Objective

To explore whether radiomics analysis of pericoronary adipose tissue (PCAT) captured by coronary computed tomography angiography (CCTA) could discriminate unstable angina (UA) from stable angina (SA).

Methods

In this single-center retrospective case-control study, coronary CT images and clinical data from 240 angina patients were collected and analyzed. Patients with unstable angina (n = 120) were well-matched with those having stable angina (n = 120). All patients were randomly divided into training (70%) and testing (30%) datasets. Automatic segmentation was performed on the pericoronary adipose tissue surrounding the proximal segments of the left anterior descending artery (LAD), left circumflex coronary artery (LCX), and right coronary artery (RCA). Corresponding radiomic features were extracted and selected, and the fat attenuation index (FAI) for these three vessels was quantified. Machine learning techniques were employed to construct the FAI and radiomic models. Multivariate logistic regression analysis was used to identify the most relevant clinical features, which were then combined with radiomic features to create clinical and integrated models. The performance of different models was compared in terms of area under the curve (AUC), calibration, clinical utility, and sensitivity.

Results

In both training and validation cohorts, the integrated model (AUC = 0.87, 0.74) demonstrated superior discriminatory ability compared to the FAI model (AUC = 0.68, 0.51), clinical feature model (AUC = 0.84, 0.67), and radiomic model (AUC = 0.85, 0.73). The nomogram derived from the combined radiomic and clinical features exhibited excellent performance in diagnosing and predicting unstable angina. Calibration curves showed good fit for all four machine learning models. Decision curve analysis indicated that the integrated model provided better clinical benefit than the other three models.

Conclusions

CCTA-based radiomics signature of PCAT is better than the FAI model in identifying unstable angina and stable angina. The integrated model constructed by combining radiomics and clinical features could further improve the diagnosis and differentiation ability of unstable angina.
Geostatistics and artificial intelligence coupling: advanced machine learning neural network regressor for experimental variogram modelling using Bayesian optimization
Authors: Soulaimani Saâd , Soulaimani Ayoub , Abdelrahman Kamal , Miftah Abdelhalim , Fnais Mohammed S. , Mondal Biraj Kanti
Published: December 2024

Experimental variogram modelling is an essential process in geostatistics. The use of artificial intelligence (AI) is a new and advanced way of automating experimental variogram modelling. One part of this AI approach is the use of population search algorithms to fine-tune hyperparameters for better prediction performing. We use Bayesian optimization for the first time to find the optimal learning parameters for more precise neural network regressor for experimental variogram modelling. The goal is to leverage the capability of Bayesian optimization to consider previous regression results to improve the output of an experimental variogram using three experimental variograms as inputs and one as output for network training, calculated from ore grades of four orebodies, characterised by the same genetic aspect. In comparison to artificial neural network architectures, the Bayesian-optimized artificial neural network demonstrably achieved the superior Coefficient of determination in validation of 78.36%. This significantly outperformed a non-optimized wide, bilayer, and tri-layer network configurations, which yielded 32.94%, 14.00%, and −46.03% for Coefficient of determination, respectively. The improved reliability of the Bayesian-optimized regressor demonstrates its superiority over traditional, non-optimized regressors, indicating that incorporating Bayesian optimization can significantly advance experimental variogram modelling, thus offering a more accurate and intelligent solution, combining geostatistics and artificial intelligence specifically machine learning for experimental variogram modelling.