bluuebunny/crossref_metadata_2025 huggingface dataset:
The Analysis of Apartment Construction Cost Disclosure Effect: Using Synthetic Control Method
Authors:   Korean Association for Housing Policy Studies, Oh Jongseok
Published: June 2024

This study analyzed whether the disclosure of apartment construction cost actually decreased apartment prices using the synthetic control method (SCM) while taking into account the sudden disclosure of apartment construction cost of Segok 2 District 4 (Gangnam Hanyang Sujain) by SH Corporation in February 2022 as a natural experiment. In the analysis, the treatment group was Set to the 85㎡ exclusive private area type of the Gangnam Hanyang Sujain, and the control group was Set to the apartment complexes located within a radius of 2km (#17), 3km (#33), 4km (#46), and 2-4km (#30) centered on the Gangnam Hanyang Sujaini, respectively.
The results of the analysis show that apartment prices do not decrease in response to the disclosure of construction cost, in cases where the apartment market price was already established. This result is consistent with various robustness checks. This suggests that the policy of disclosing construction cost to stabilize apartment prices may not align with its purpose.
A Short-Run Equilibrium Model for Housing Markets Encompassing both Sales and Rental Markets
Authors:   Korean Association for Housing Policy Studies, Yun Sungho
Published: June 2024

In this study, we introduce a concise short-run equilibrium model for the housing market, covering sales and two distinct rental markets - monthly rent and Jeonsei markets. This model enables us to analyze the interplay among these markets and examine the determinants of equilibrium sales prices, monthly rent, and Jeonsei prices. Unlike monthly rent, the actual cost to a tenant in Jeonsei (interest on the Jeonsei deposit) depends on the tenant’s equity size, and the cost of ownership in Jeonsei differs from that in monthly rent. We incorporate these distinctions between monthly rent and Jeonsei contracts into our model and observe that the housing market's equilibrium is influenced by the type of rental market. We also examine the effects of an increase in real estate holding tax and find that sales prices decrease irrespective of the type of rental market. However, the impact on monthly rental fees and Jeonsei prices depends on the rental market structure: monthly rental fees do not change only if monthly rental is available, Jeonsei prices increase if only Jeonsei is available, and both monthly rental fees and Jeonsei prices increase if both types of rents are available.
NEUROSYPHILIS IN PEDIATRIC POPULATION: A REVIEW OF CASES
Authors: Calado Cabral Camila , Cañedo Mayara Carolina , Rossato Luana , Simionatto Simone
Published: June 2024

Background: Neurosyphilis is the most severe presentation of acquired and congenital syphilis, it occurs when Treponema pallidum penetrates the central nervous system. This development can occur at any time during the evolution of the disease phases. In Brazil in 2021, 2,343 children born with congenital syphilis were diagnosed with neurosyphilis, representing 9.3% of the total. The objective of this study was to analyze the scientific evidence on the medical manifestations presented by pediatric patients affected by neurosyphilis. Methods: In February 2023, PubMed, VHL, Scopus, Lilacs and Bdenf databases were researched for published case reports of patients aged zero to less than 18 years with T. pallidum infection. The data analysis period covered 55 years. Results: Nine articles were found in the period of publication from 1967 to 2022. There were two cases in females and only one with manifestation in an adolescent of acquired neurosyphilis. The adolescent's case was the only one with a favorable outcome after adequate treatment. Other cases resulted in impaired quality of life for patients and family members involved in child care. Conclusion: The reported cases of neurosyphilis were mostly related to late diagnosis. Evidencing the fragility of prenatal care, which is crucial for prevention and intervention by T. pallidum infection causes serious consequences for child development. Therefore, control measures should focus on mandatory prenatal screening during the first trimester of pregnancy, partner notification, prompt treatment and postnatal follow-up of the newborn.
CONFLICT IN ORGANIZATIONS: ITS CONNECTION TO A HEALTHY AND PRODUCTIVE WORK ENVIRONMENT
Authors: Cahya Ningtyas Adinda Suci
Published: June 2024

In this day and age, conflict is a topic that is still being discussed. Conflict cannot be completely avoided in an organization, but it can be managed by minimizing it. The study employed a qualitative approach using systematic literature review methods to analyze and synthesize existing research on organizational conflict and its implications for healthy and productive work environments. Data collection involved reviewing 30 articles from reputable national and international journals, focusing on conflict management, leadership styles, and the impact of external factors on organizational dynamics. Effective conflict management by organizational leaders is essential in fostering a cooperative environment for handling conflicts within teams. Constructive conflict management can lead to positive changes and learning experiences for all parties involved in organizational conflicts. Effective conflict resolution strategies can stimulate innovative problem-solving among employees and prevent a decline in motivation and creativity due to high levels of conflict.
Conservative Treatment of Apophyseal Avulsion Injuries at the Iliac Crest and Anterior Superior Iliac Spine in a Competitive Female Irish Dancer: A Case Report
Authors: Hildebrand Danielle , McLane Melissa
Published: June 2024

Background

A 14-year-old female competitive Irish dancer was referred to physical therapy with a 1-week onset of sudden left hip pain.

Case Presentation

Evaluation and imaging revealed apophyseal avulsion injuries of the left iliac crest apophysis. Additional injuries included partial tears involving insertions of the transversus abdominis and left internal oblique at the iliac crest.

Outcome and Follow-Up

Successful completion of 4 months of physical therapy returned the Irish dancer to the competitive stage at performance level.

Discussion

This case provides a description of the diagnostic process and early management of an avulsion injury to the pelvis in an Irish dancer. JOSPT Cases 2022;2(1):1–10. doi:10.2519/josptcases.2022.10566
A Rehabilitation Progression for a Baseball Athlete Following Anterior Cruciate Ligament Reconstruction: A Case Report
Authors: Andreyo Evan , Unverzagt Casey , Tompkins Jeff
Published: June 2024

Background

Clinicians have long sought to return athletes safely and expeditiously to sport after anterior cruciate ligament reconstruction. No current literature exists showcasing the rehabilitation progression and testing battery that addresses the unique sport-specific demands of a high school baseball athlete. The purpose of this case study is to address a gap in the literature by providing an example of the postoperative management of a high school baseball player.

Case Presentation

An 18-year-old baseball player presented to physical therapy following anterior cruciate ligament reconstruction. He participated in a sport-specific 9-month course of rehabilitation.

Outcome and Follow-Up

The athlete was cleared for competitive baseball at 9 months post-surgery after completion of a comprehensive rehabilitation program and return-to-sport testing battery uniquely tailored toward the demands of his sport.

Discussion

The case study demonstrates the use of sport-specific rehabilitation strategies and return-to-sport testing for a high school baseball player. After a multidisciplinary consensus was reached regarding return-to-sport readiness, the athlete successfully returned to competitive baseball. JOSPT Cases 2022;2(2):64–84. doi:10.2519/josptcases.2022.10804
A Physical Therapist's Experience as a Point-of-Contact Care Provider in a Wilderness Environment: A Case Series Report
Authors: Young Brian A. , Beattie Paul F.
Published: June 2024

Background

Wilderness physical therapists (WPTs) are on-scene primary providers who combine physical therapy, emergency first aid, and wilderness survival skills to manage people with a wide array of injuries and illnesses in remote environments.

Case Presentation

Patient 1, a 51-year-old female, was unable to bear weight after sustaining a right knee injury from falling into a river while hiking. The WPT immobilized a suspected knee fracture using a SAM® Splint, moved the patient and her group to safer location, and constructed a shelter. Shortly after, patient 2, a 14-year-old male, fell and sustained a forehead laceration. Hemostasis was obtained and the patient was monitored for neurologic abnormalities. Safety was complicated by rainfall, darkness, and the absence of cell service to notify emergency medical services.

Outcome and Follow-Up

Emergency medical services arrived 4 hours after the initial injury and evacuated both individuals. Plain film radiographs of patient 1's knee were interpreted as normal; however, subsequent magnetic resonance imaging revealed a posterior tibial plateau fracture with ligamentous injury. Following a 20-hour observation period, patient 2 was returned to continue the hike with his group.

Discussion

This case illustrates the emergency medical, leadership, and situational awareness skills required of a WPT. This case also illustrates the in-field application of the Ottawa knee rules and the importance of careful neurologic assessment in individuals with head trauma. JOSPT Cases 2022;2(3):175–182. Epub: 21 June 2022. doi:10.2519/josptcases.2022.10944
Trial of NewGait™ to Improve Gait and Sit-to-Stand Mechanics in an Older Adult Following Total Joint Replacements: A Case Report
Authors: Tooman Kathleen M. , Weiler Jozie , Larson Cathy A.
Published: June 2024

BACKGROUND: Joint replacements following years of osteoarthritis create disruptions in functional activities that are challenging to modify. The purpose of this case report was to describe the use and efficacy of the NewGait™, a device that is designed to facilitate, stabilize, and inhibit muscles used during functional activities such as walking and sit to stand, for a person with bilateral hip and knee replacements.

CASE PRESENTATION: This 69-year-old male participant had previously received physical therapy interventions after multiple surgeries. Residual impairments and functional deficits remained 5 years postoperatively including slow, unsteady gait and functional activity limitations. NewGait™ was used as a sole treatment for 10 sessions.

OUTCOMES Goals to improve safety and speed in sit to stand and gait, as well as the ability to get in/out of cars and on/off a bike, were achieved.

DISCUSSION: Further exploration as to the efficacy of the NewGait™ to alter gait and function is warranted. JOSPT Cases 2023;3(1):43–52. Epub: 4 November 2022. doi:10.2519/josptcases.2022.11282
Novel Blood Flow Restriction Therapy Protocol for the Treatment of Postamputation Weakness and Pain due to Osteosarcoma: A Case Study
Authors: Prescott Elyse , Schweizer Beth , Cheney Cole
Published: June 2024

BACKGROUND: Pain and weakness are 2 commonly reported postamputation symptoms. The purpose of this case report is to propose a novel blood flow restriction (BFR) protocol to address pain and weakness in a patient with transtibial limb loss.

CASE PRESENTATION: A 36-year-old male 2 months after transtibial amputation presented for evaluation and treatment of his postamputation pain, weakness, and poor functional mobility. The patient completed a novel BFR strength protocol twice per week for 12 weeks.

OUTCOME AND FOLLOW-UP: Amputee Mobility Predictor, L Test Measure of Functional Mobility, 2-minute walk test, 30-second sit to stand, hamstring force, single-limb leg press repetition maximum, hip abduction endurance test, and numeric pain scale preintervention and postintervention were measured. The patient achieved the minimal detectable change for the L-Test and 2MWT, resulting in meaningful improvement in the patient’s strength and function following the blood flow restriction protocol.

DISCUSSION: This case supports the use of blood flow restriction to address postamputation weakness and pain in a physical therapy setting. JOSPT Cases 2024;4(1):1-7. Epub 30 November 2023. doi:10.2519/josptcases.2023.11327
“I Was Focused on the Game and Not on My Shoulder.” A Case Report on the Use of Virtual Reality in the Rehabilitation of an Unstable Shoulder
Authors: Dejaco Beate , Wagener Marc , Lewis Jeremy
Published: June 2024

BACKGROUND: People living with shoulder instability commonly experience pain and a substantial decrease in function. Equivocal evidence relating to different interventions has resulted in inconsistent rehabilitation suggestions.

CASE PRESENTATION: A young athlete with a history of shoulder pain and the constant perception of shoulder instability underwent rehabilitation using immersive virtual reality (VR). Prior to this intervention, the athlete reported unsuccessful nonsurgical treatment for her shoulder. She was living with pain and movement restriction and had withdrawn from competitive sport.

OUTCOME AND FOLLOW-UP: After using a VR device for 3 weeks at home, an increase in shoulder range of movement (abduction from 25°-90°, flexion from 30°-110°, and external rotation from 5°-50°) and a decrease in pain (from 7/10 to 4/10) were achieved.

DISCUSSION: Although causality cannot be inferred, this case report highlights the potential of immersive VR in the treatment of young patients with perceived shoulder instability, pain, and decreased function. JOSPT Cases 2023;3(3):158-162. Epub: 20 June 2023. doi:10.2519/josptcases.2023.11363
Physical Therapy Management of Pelvic Pain in Men: Two Case Reports
Authors: Nitzkorski Allison M. , Oie Annika K. , Romero Jara Nathaly J. , Williams Austin J. , Herrmann Amanda A.
Published: June 2024

BACKGROUND: The purpose of this case report is to describe 2 cases where individualized pelvic floor physical therapy (PFPT) was used to care for 2 individuals with general pelvic pain.

CASE PRESENTATION: Two male patients with pelvic pain and urinary dysfunction were referred to PFPT. Assessment of breathing pattern, the pelvic floor, and the pelvic girdle were performed. Goals were set with a therapist to address their chief complaints and reduce pelvic pain through use of muscle energy techniques, manual therapy, therapeutic exercise, and behavioral modifications.

FOLLOW-UP: Both patients improved after only 4 physical therapy treatment sessions and reported clinically significant improvements in National Institutes of Health Chronic Prostatitis Symptom Index scores.

DISCUSSION: The successful and rapid resolution of symptoms in these cases demonstrates the potential benefits of PFPT, patient compliance, and timely referrals to PFPT to expedite outcomes. JOSPT Cases 2023;3(4):227-232. Epub 11 September 2023. doi:10.2519/josptcases.2023.11495
Extrasynovial ACL Tear as Potential Indicator for ACL Healing Capability: A Case Report of a Recreational Football Player With 3 Years of Serial Follow-up Tracking ACL Healing
Authors: Serner Andreas , Sas Bart , D’Hooghe Pieter , Arnaiz Javier
Published: June 2024

BACKGROUND: Potential structural anterior cruciate ligament (ACL) healing is receiving increased focus with several studies showing that variations of ACL healing capacities are possible. It is unknown if there are specific variations in ACL tears, which have higher probability of healing.

CASE PRESENTATION: We present a successful case of nonsurgical treatment of a complete ACL injury in a 34-year-old male recreational football player that showed proposed initial magnetic resonance imaging indicators of ACL healing potential: (1) the ligament fibers of the proximal and distal ends run mostly in the same direction (no displacement of ligament stumps), (2) no significant high signal intensity surrounding the torn ACL in water sensitive sequences, and (3) absence of significant joint effusion.

OUTCOME AND FOLLOW-UP: Follow-up included a series of 10 continuous magnetic resonance imaging examinations showing ACL healing progress in steps, as well as continuous clinical and biomechanical examination from injury to return to sport (4.5 months after injury) and until 3-year after injury.

DISCUSSION: We propose that an extrasynovial ACL tear might be an early indicator of ACL healing capability and provide considerations and illustrations, which may assist in the detection thereof. Further investigation and validation of this theory is encouraged. JOSPT Cases 2023;3(4):212-218. Epub 13 October 2023. doi:10.2519/josptcases.2023.11747
Patient Identified Factors That Help Improve Second Periacetabular Osteotomy Surgical Outcome as Compared to First for Bilateral Hip Dysplasia: A Case Report
Authors: Pierson Christopher , Etibo Kristen , Middleton Emily , Yanney Rayce , Wells Joel
Published: June 2024

BACKGROUND: The patient experience with physical therapy rehabilitation has not been well described following periacetabular osteotomy (PAO) surgery. The purpose of this study is to explore patient-identified factors that can improve physical therapy rehabilitation following a PAO surgery. A secondary purpose is to provide a treatment framework for the physical therapist treating a patient following this surgery.

CASE PRESENTATION: The subject of this case study is an otherwise healthy 31-year-old woman initially presenting with symptomatic bilateral hip dysplasia. She underwent right PAO in 2020 and left PAO in 2021.

OUTCOME AND FOLLOW UP: Authors were able to collect follow-up subjective and objective data for up to one year post surgery on each hip.

DISCUSSION: The patient identified several factors that improved her second recovery as compared to her first. Clinicians can use this information to augment their plans-of-care for patients presenting for postoperative PAO rehabilitation. JOSPT Cases 2023;3(4):251-259. Epub 10 August 2023. doi:10.2519/josptcases.2023.11783
Laceration of the Distal Biceps Femoris Tendon
Authors: Droge Jed
Published: June 2024

BACKGROUND: Rehabilitation strategies addressing impairments caused by hamstring laceration injuries remain insufficiently explored in current literature.

CASE PRESENTATION: This case study presents the effective management of a 62-year-old male who experienced pain, weakness, and range-of-motion loss secondary to a distal biceps femoris tendon laceration. Treatment incorporated interventions traditionally utilized for acute athletic hamstring injury.

OUTCOME AND FOLLOW-UP: Clinically meaningful improvements were made in active knee extension range of motion, as well as isometric knee flexor and hip extensor strength over 10 weeks. He was able to return to running for aerobic fitness and improved his Lower Extremity Functional Scale score from 13/80, initially, to 76/80 at 12 months.

DISCUSSION: This case suggests the use of evidence-based interventions for hamstring strain may be useful for management of partial tendon laceration injuries. JOSPT Cases 2024;4(2):74-78. Epub 2 May 2024. doi:10.2519/josptcases.2024.0003
Pain Neuroscience Education Approach to the Physical Therapy Management of Post-Covid Conditions (PCC): A Case Report
Authors: Thobaben Arlyn , Stone Jennifer , Migliano Pedro , Aziz Rija
Published: June 2024

BACKGROUND: The emergence and prevalence of post-COVID conditions (PCC) has presented health care providers with an urgent need to determine best practices for treatment and rehabilitation of this condition.

CASE PRESENTATION: A 43-year-old female with PCC presents to physical therapy via telerehabilitation. Primary complaints included chest pain, throat pain, postexertional malaise (PEM), and breathing dysfunction. Therapeutic intervention included individually titrated exercise and activity to address symptoms and limitations, through a pain neuroscience education approach.

OUTCOME: The patient demonstrated improvements in her 30-second sit to stand (mean change: 11 repetitions), resting heart rate (mean change: −6 bpm), patient-specific functional scale (mean change 1.7), and global rating of change score of 6.5.

DISCUSSION: The patient made objective and subjective improvements in function and was satisfied with her telerehabilitation. This case demonstrates the feasibility of the telehealth setting and clinical utility of pain neuroscience education as the basis for the physical therapy management of PCC. JOSPT Cases 2024;4(2):64-71. Epub 2 May 2024. doi:10.2519/josptcases.2024.0004
Unrecognized Superficial Venous Thrombosis in a Female Division-1 Athlete: A Case Report
Authors: Coombs Stephen D. , Borhani Martin , Wielechowski Adam
Published: June 2024

BACKGROUND: Superficial venous thrombosis (SVT) is a blood clot that forms in superficial veins and may occur after surgery. Treatment typically consists of anticoagulation medication and palliative care.

CASE PRESENTATION: A 20-year-old female basketball athlete presented to physical therapy (PT) after posterior labral repair. Examination revealed tenderness along the medial forearm, venous distension of the hand, and discomfort with wrist extension overpressure and resisted wrist flexion. The patient was referred by the physical therapist to the team physician, who ordered ultrasonography, which demonstrated SVT of the right basilic vein. The patient was placed on anticoagulation medication for 4 months.

OUTCOME AND FOLLOW-UP: At 4 months after initial diagnosis, a computed tomography venogram revealed resolution of SVT. The patient continued with physical therapy throughout this period, with no adverse effects reported.

DISCUSSION: Physical therapists play an important role in medical screening and referral of patients who present with potential vascular complications postsurgery. Physical therapists may also safely implement a plan of care in patients who develop medical complications after surgery. JOSPT Cases 2024;4(1):34-38. Epub 26 January 2024. doi:10.2519/josptcases.2024.12174
A CONTRIBUIÇÃO DA DOUTRINA DA DEFESA DO CONSUMIDOR PARA O COMBATE DO CONSUMISMO INFANTOJUVENIL
Authors: Eduardo Ribeiro Santos Luis , Silva Conceição Adriane , Henrique Pereira Marques Cleiton , Cecilia Lima Reis Ana , Duarte Nascimento Thaiana , Silva dos Reis Thais , Gonçalves de Oliveira Welber , Silva Sales Barbosa Esdras , Pedro Gonzalez Junior Ivo
Published: June 2024

Introdução: Na sociedade contemporânea é notório que o alto índice de consumismo está se expandindo em uma velocidade assustadora, o que ocasiona em problemas graves para o consumidor. Diante disso, nota-se uma preocupação acerca das crianças e adolescentes que passam por um período de construção do tirocínio, o que corrobora na submissão a esse tipo de propaganda abusiva. No entanto, já existem mecanismos jurídicos que atuam na prevenção desse tipo de propaganda, como por exemplo, o Código de Defesa do Consumidor, e se faz necessário questionar como esse mecanismo pode contribuir no embate contra o consumismo infanto-juvenil.
Objetivo: Esse estudo tem como principal objetivo buscar compreender os instrumentos jurídicos respaldados na lei, além de tentar compreender até que ponto as estratégias publicitárias usadas para atrair o público infanto juvenil podem permear no nosso cotidiano.
Método: Este trabalho é um trabalho de caráter qualitativo oriunda de uma revisão bibliográfica. A pesquisa foi realizada com o auxílio de artigos científicos, normas jurídicas e doutrina. A investigação acerca do tema proposto foi realizada entre abril e maio de 2023.
Resultados (esperados/parciais): Espera-se analisar mecanismos já assegurados em lei com o intuito de erradicar o consumismo impróprio de crianças e adolescentes. É importante ressaltar que, a pesquisa tem o desejo de encontrar também novos mecanismos que possam auxiliar a fiscalização de propagandas abusivas e enganosas, que estão atreladas ao público infanto-juvenil e auxilie a população a ter uma mudança de mentalidade acerca dos paradigmas associados a essa falsa publicidade.
Palavras – chaves: Propagandas abusivas; Infanto-juvenil; Consumidor; Direito do consumidor; Prevenção.
Eixo temático: Ciências sociais aplicadas
TÁTICAS DE SOFT SKILLS APLICADAS POR UMA EMPREENDEDORA NO RAMO VAREJISTA
Authors: Feitosa Lima Joycivânia , Santos da Silva Jó
Published: June 2024

Introdução: O mundo empresarial exige cada vez mais o desenvolvimento de competências relacionadas as habilidades técnicas (hard skills) como, por exemplo, as competências tecnológicas, gerenciamento de projetos, análise de dados, quanto as habilidades interpessoais (soft skills), a saber, a capacidade de se comunicar bem, a habilidade de negociar, a de liderar, e a de atuar na gestão de empresas nacionais quanto internacionais. Notadamente, para o desenvolvimento deste estudo abordaremos a negociação como campo de investigação, uma vez que tal competência é considerada pela literatura como uma das habilidades interpessoais desenvolvidas por grandes gestores de sucesso. Em síntese, negociar é quando duas ou mais pessoas têm uma conversa para atingir um acordo adequado para ambos. Um gestor, ao ser um excelente negociador, tem como característica tais habilidades supracitadas. Como objeto de estudo, a investigação científica será aplicada tendo como objeto de investigação, táticas de soft skills desenvolvidas por uma empreendedora que atua no setor varejista, na cidade de Feira de Santana, no estado da Bahia, Brasil. Como pergunta norteadora, tem-se o seguinte questionamento: quais são as habilidades interpessoais desenvolvidas por uma gestora que favorece o processo de negociação? A justificativa, destaca-se pela importância de entender como os aspectos interpessoais contribui para o aumento eficiência da competitividade e de um posicionamento estratégico organizacional superior durante o processo negocial.
Objetivo: Identificar as habilidades interpessoais desenvolvidas por uma empreendedora que atua em uma rede de supermercados e que favorecem o processo de negociação.
Método: A abordagem investigativa da pesquisa a ser utilizada será qualitativa, com objetivos do campo de investigação e avaliação sendo descritiva e exploratória. A metodologia aplicada será um estudo de caso, do tipo único e o tipo de projeto holístico de única unidade, a verificação da qualidade será de fonte única de prova (entrevista) realizando um relatório de estudo e a sua estrutura analítica, não comparativa e não sequenciadas. A coleta dos dados será feita mediante um instrumento semiestruturado. O universo escolhido é uma empresa que atua no setor varejista, sendo, a amostra intencional e não probabilística por acessibilidade.
Resultados (esperados / parciais): Espera-se que o presente estudo coopere para a compreensão de como as competências interpessoais influenciam no processo negocial do dia a dia de uma empresa no ramo de varejo. Além disso, espera-se através dessa pesquisa proporcionar a outros gestores ou profissionais que atuam na área, o entendimento e a relevância das soft skills, sendo habilidades tão indispensáveis as futuras empreendedoras quem pretendem construir uma carreira de sucesso no mundo corporativo.
Descritores: Soft skills; Empreendedorismo; Negociação; Varejo.
Eixo temático: Ciências Sociais Aplicadas.
Hidradenitis suppurativa as seen by the patient
Authors: Martynov Andrey A. , Vlasova Anna A. , Mishina Olesya S.
Published: June 2024

Background. Hidradenitis suppurativa (HS) is a common disease that significantly reduces the quality of life of patients of reproductive age, while its exact prevalence is unknown in most countries due to untimely and poor-quality diagnosis.
Aim. In order to clarify the prevalence of HS, an analysis of the structure of newly identified cases of this disease was carried out in the conditions of the consultative and diagnostic center of the State Research Center of Dermatovenereology and Cosmetology of the Ministry of Health of the Russian Federation for the period 2008–2021 inclusive. In order to study the characteristics of the course of HS, its impact on behavior and receipt of medical care from the patient’s point of view, an anonymous quantitative online survey of patients was conducted. The patient questionnaire “Shin a light on hidradenitis” was used as a basis.
Methods. Аnonymous quantitative online survey of patients was conducted. The patient questionnaire “Shin a light on hidradenitis” was used as a basis.
Results. For the period 2008–2021 exclusively under the section “L73 Other diseases of the hair follicles”, 765 cases were diagnosed in the State Scientific Center for Disease Control and Prevention (0.36% of the total number of all newly diagnosed cases). The diagnosis of GG (ICD code L73.2) was first established only in 59 cases (about 8% of identified cases using code L73). 1035 respondents took part in the survey. The survey revealed that patients with HS are worried about: 66% — swelling, 55% — pain, 38% — purulent discharge and/or blood, 25% of patients note a disturbing look. Most patients rated the severity of pain as moderate (29%) and low (29%) pain, severe and very severe pain — 12 and 7% respectively. Among the treatments used for HH, patients recommended: antibiotics (34%), opening and drainage (32%), prescription corticosteroid creams/ointments (11%), and biologics (4%). In 44% of patients, a visit to a doctor to provide qualified assistance continues; 18% of patients are observed by one doctor (dermatologist and/or surgeon); 9% of patients visited 2–3 doctors before receiving the necessary help.
Conclusion. All over the world, the “search” for a specialist who will correctly diagnose, prescribe adequate treatment and accompany its long process is still a complex and unsolved task. In order to improve the quality of medical care for patients with HH, it is necessary to develop and implement domestic clinical recommendations, as well as the development and implementation of educational programs for interested specialists.
Post-Diarrheal Acute Kidney Injury During an Epidemic in Monsoon – A Retrospective Study from a Tertiary Care Hospital
Authors: Haridas Nived , Thirumavalavan S. , Fernando M. Edwin , Vellaisamy Murugesan , Annadurai Poongodi , Srinivasaprasad N.D. , Surendran Sujit , Valavan K. Thirumal , Joseph Jerry , Gayathri M.S.
Published: June 2024

Background:

Acute kidney injury (AKI) is a severe complication of acute diarrheal diseases; however, there is limited data on post-diarrheal AKI (PD-AKI) epidemiology and outcomes. This study aimed to investigate the clinicodemographic profile and outcomes of PD-AKI in our hospital.

Materials and Methods:

We retrospectively analyzed data from 93 patients admitted with PD-AKI during a diarrheal illness epidemic. Patients were stratified based on the Kidney Disease: Improving Global Outcomes (KDIGO) AKI stage and quick Sequential Organ Failure Assessment (qSOFA) score. Clinicodemographic data and outcomes were recorded and analyzed.

Results:

The mean age of the patients was 45.7 ± 11.9 years, with a majority being men (n = 55, 59%). All patients presented with watery diarrhea, 85% (n = 79) had vomiting, and 66% (n = 61) presented in shock. At presentation, 59% were oliguric, while 32% were anuric. KDIGO stage 3 AKI was observed in 71% (n = 66) of patients. Dialytic support was required in 29% (n = 27) of cases. The mortality rate was 6.5% (n = 6), mostly due to refractory shock, while the remaining patients recovered. Risk factor analysis demonstrated a higher qSOFA score, and peak serum creatinine levels were associated with an increased likelihood of requiring renal replacement therapy and delayed renal recovery.

Conclusion:

This study provides valuable insights into the clinicodemographic characteristics and outcomes of PD-AKI. The high prevalence of severe AKI emphasizes the importance of early recognition and appropriate management strategies for these patients.
Bones, Stones, and Hematuria - Connecting the Dots
Authors: Fadnis Madhura P. , Kalrao Vijay , Kalra Suprita , Acharya Suchi
Published: June 2024

We report a 12 yr old boy who presented with recurrent gross hematuria, polyuria and rickets with growth failure. Investigations showed bilateral renal calculi with small kidneys on ultrasonography along with hypercalciuria; hypomagnesemia and reduced kidney function. His younger sibling also had nephrocalcinosis hypomagnesemia. The genetic analysis done in view of recurrent renal calculi with chronic kidney disease showed a homozygous missense variant (c.392G>A) at exon 4 of CLDN 16 gene suggestive of Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC). The younger sibling had a similar homozygous mutation and the parents were heterozygous carriers.
HEMOSTATIC DISORDERS IN NON-TUMOR MECHANICAL JAUNDICE AND CHOLANGITIS IN CORRELTION TO THE SEVERITY OF THE LATTER AND TO FIBRINOGEN GENE POLYMORPHISM
Authors:   Mordovian State University, Saransk, Russian Federation, Al-Kubaysi Sh. S. , Vlasov A. P. ,   Mordovian State University, Saransk, Russian Federation, Sheiranov N. S. ,   Mordovian State University, Saransk, Russian Federation, Myshkina N. A. ,   Mordovian State University, Saransk, Russian Federation, Dukhovnova K. S. ,   Penza State University, Penza, Russian Federation, Abramov A. A. ,   Mordovian State University, Saransk, Russian Federation
Published: June 2024

Background. Mechanical jaundice (MF) and cholangitis are considered to be of great significance in emergency surgery due to their complex pathogenesis, risk of complications and high mortality. Objective. To establish the severity of hemostatic disorders in association with fibrinogen gene polymorphism (FGB (G(-455)A)) in patients with non-cancerous MF and cholangitis of varying severity. Material and methods. The subjects were 25 patients with benign MF and cholangitis divided into 2 groups: group 1 (n=12) – those with a mild form of the disease; group 2 (n=13) – those with a severe form. The research methods included the assessment of endogenous intoxication, liver function as well as blood coagulation activity. Genetic analysis of the FGB (G(-455) geneA)) was performed using a polymerase chain reaction by Real–time PCR. The severity of the disease was determined using the V.D. Fedorov scale (2000). Results. The early stage of MF and cholangitis is accompanied by endotoxicosis, resulting in the damage of a number of organs and systems, in particular the liver. The latter plays an important role in changing the activity of blood coagulation system. These disorders had a strong correlation with the severity of the disease: in mild cases, the character was less pronounced and reversible, and in severe cases – persistent and severe. Hemostatic disorders recorded in the early period of the disease depend on the severity: in mild cases, hypercoagulation and normofibrinolysis are noted, and in severe cases – hypocoagulation and hypofibrinolysis. Genetic polymorphism of the fibrinogen gene FGB (G(-455)A) had a significant impact on the pathogenetic process of MF and cholangitis. Patients with the mutant genotype (A/A) of the FGB gene were found to show the greatest severity of homeostasis system violation when compared with patients with genotypes G/G and G/A – with minimal imbalance. Conclusions. Hemostatic disorders associated with polymorphism of the fibrinogen gene FGB (G(-455)A) play an important role in the pathogenesis of MF and cholangitis.
PREGNANCY AND CHILDBIRTH COURSE PECUARITIES IN WOMEN SUFFERING FROM CHRONIC VIRAL HEPATITIS
Authors:   Kyrgyz-Russian Slavic University, Bishkek, Kyrgyz Republic, Abdikerimova M. M.
Published: June 2024

Background. Chronic viral hepatitis (CVH) B and C are considered socially significant infections. More than 290 million people worldwide live with chronic hepatitis B (CHB) and more than 58 million have been infected with hepatitis C virus (HCV). Every year, about 1.5 million people become newly infected. In recent years, chronic hepatitis has occupied one of the leading places in the structure of extragenital pathology in pregnant women. Objective. To evaluate the characteristics of pregnancy and childbirth course in women with CHB, CHC and CHB+СHC. Material and methods. The paper presents the results of a retrospective analysis of 141 individual records of pregnant women with CHB, CHC and CHB+СHC and their birth histories. The average age of pregnant women was 25.1±3.72 years. Results. CHB, CHC and CHB+СHC negatively affect the course of pregnancy: the threat of miscarriage and the frequency of gestosis increase, chronic fetoplacental insufficiency and polyhydramnios are more often detected, premature birth occurs as well. Childbirth in pregnant women with chronic hepatitis is accompanied by the development of complications: hypotonic uterine contractions, premature rupture of membranes. Chronic HCV-infection causes more serious metabolic changes than HBV, which significantly complicate the course of pregnancy and childbirth. Conclusions. CHB, CHC and CHB+СHC negatively affect the course of pregnancy and childbirth.
LAPAROSCOPIC PANCREATOCYSTOEJUNOSTOMY
Authors:   Grodno State Medical University, Grodno, Belarus, Mahiliavets E. V. , Zhuk I. G. ,   Grodno State Medical University, Grodno, Belarus, Shidlovsky D. V. ,   Grodno State Medical University, Grodno, Belarus
Published: June 2024

Background. Pancreatic pseudocyst formation is known to be one of the most common complications of chronic pancreatitis. Despite the widespread use of the laparoscopy, it is still relatively rarely employed in pancreatic surgery. Objective. To analyze the outcomes of laparoscopic Roux-en-Y pancreatocytojejunostomy as well as to present a brief literature review. Material and methods. Data from diagnostic examinations, laboratory tests, as well as the outcomes of surgical treatment of a female patient for a pancreatic cyst are presented. It is worth noting that a laparoscopic Roux-en-Y pancreatocystojejunostomy was used for pancreatic cyst treatment in this case. Results. Successfully performed laparoscopic surgery enabled to preserve as much of the pancreas as possible and to avoid postoperative complications. Conclusions. The described case, along with the reviewed publications, indicate that laparoscopic internal drainage may be regarded as a feasible method for the treatment of encapsulated cysts of the body and tail of the pancreas in chronic pancreatitis. This is due to the fact that this surgical option doesn’t involve pancreatic parenchyma volume reduction and has a lower risk of relapse as compared with external drainage methods. Based on the above mentioned, the choice of this method is associated with relatively minimal surgical trauma, fewer complications and a short-term postoperative period. To perform such operations successfully, special tools and skills are required. The presence of domestically produced endoscopic staplers contributes to the further implementation of this type of intervention into practice.
The method of rational distribution of information protection tasks of an information system based on the Lagrange multiplier method
Authors: Александр А.А.
Published: June 2024

Рассмотрен анализ использования программных средств защиты информации работы информационных систем. С помощью классического метода, основанного на дифференциальном исчислении, описано задействование вычислительных ресурсов для совместного решения прикладных задач и задач защиты информации в информационной системе. Для составления рационального расписания задач защиты информации в информационной системе использован метод множителей Лагранжа. В качестве критерия оптимальности выбрана динамическая погрешность вычислений. Исследована организация вычислительного процесса системы реального времени при выполнении задач защиты информации.

The analysis of the use of software tools for information protection of information systems is considered. Using the classical method based on differential calculus, the use of computing resources for the joint solution of applied problems and information security problems is described in the information system. To compile a rational schedule of information security tasks in the information system, the Lagrange multiplier method was used. The dynamic error of calculations is chosen as the criterion of optimality. The organization of the computing process of a real-time system when performing information security tasks is investigated.
Complex modifier for the preparation of crushed stone-mastic asphalt concrete mixtures
Authors: Егор О.П. , Петр В.М. , Владимир Е.Н. , Дмитрий Ю.Н.
Published: June 2024

Рост интенсивности движения автомобильного транспорта поднимает уровень требований к стабильности качества асфальтобетонных смесей и асфальтобетонов на их основе. Решение данного вопроса может быть обеспечено путем использования комплексных модификаторов сухого ввода в составе асфальтобетонных смесей. Созданный ПК «Стилобит» комплексный модификатор «Стилобит PRO» на основе смеси неорганических волокнистых материалов и полимерсодержащих компонентов позволяет решить две основные задачи. Первая состоит в обеспечении стабильной во времени пленки битумноговяжущего на поверхности минерального заполнителя, что позволит предотвратить оголение поверхности минеральных материалов и создаст условия для надежного адгезионного контакта на границе раздела битумное вяжущее—минеральный заполнитель. Вторая задача – это регулирование свойств самого битумного вяжущего путем введения полимерсодержащих компонентов из состава комплексного модификатора «Стилобит PRO». В ходе данной работы проведено сопоставление показателейасфальтобетонных смесей на основе трех добавок: «Viatop 66», «Стилобит», «Стилобит PRO». Показанаэффективность их применения на примере смеси ЩМА-16.

The increase in the intensity of motor transport traffic raises the level of requirements for the stability of the quality of asphalt concrete mixtures and asphalt concretes based on them. The solution to thisissue can be provided by using complex dry injection modifiers in asphalt concrete mixtures. Created by PC Stylobit LLC, the “Stylobit PRO” complex modifier based on a mixture of inorganic fibrous materials andpolymer-containing components is aimed at solving two main tasks. The first of them is to ensure the presence of a time-stable bitumen binder film on the surface of the mineral filler. This will prevent the surface of mineral materials from being exposed and create conditions for reliable adhesive contact at the interface between bitumen binder andmineral filler. The second task is to regulate the properties of the bitumen binder by introducingpolymer–containing components from the composition of the complex modifier “Stilobit PRO”. In the course of this work, a comparison of the indicators of mixtures of “ShchMA-16” based on three additives was carried out:“Viatop 66”, “ Stilobit” and “Stilobit PRO”.
Increasing Atomic Electron Cloud Density Leads to Formation of Body Centered Cubic (BCC) Gold
Authors: Gu Hengfei , Ren Jie , Wu Songquan , Li Mingyuan , Zhang Lifeng , Liu Chengze , Yuan Fusen , Han Fuzhou , Zhang Yingdong , Ali Muhammad , Guo Wenbin , Li Geping
Published: June 2024

Most metallic elements possess one relatively close packed structure of body-centered cubic (BCC), face-centered cubic (FCC) and hexagonal close packed (HCP) structures under ambient conditions. Access to these structures as a function of temperature and pressure varies for different groups in the periodic table. Under low pressures, the copper group elements (copper (Cu), silver (Ag) and gold (Au)) only has a FCC solid structure regardless of temperatures. Recently, BCC Au was detected under extreme pressures. The structural preference for a given metal element is still not understood. In this work, we surprisingly observed formation of BCC Au from amorphous Au as well as FCC Au within an electron self-transferred Au nanoparticle supported by our synthesized zirconium hydroxide nitrate tube in vacuum at room temperature. We propose a theory behind this unexpected phase formation: the increase in atomic electron cloud densities of Au atoms enabled by the electron transfer contributes more free electrons over the Au nanoparticle, enhancing metallic bonding strength to hold Au atoms closer to form a BCC structure that can store denser electron states within a Fermi sphere in first Brillouin zone as compared to FCC Au. This can also explain formation of BCC Au under compression. Our theory here can be a supplement to the metallic bonding theory and our strategy can guide how to expand the structure world of metals under ambient conditions for beneficial applications.
Purification of Au/Au Core/Satellite Supraparticles by Asymmetric Flow Field Flow Fractionation for SERS Nanotag-based Applications
Authors: Waasmann Louisa , Kleinschmidt Annika , Stepula Elzbieta , Sanders Carolin , Walkenfort Bernd , Schlücker Sebastian
Published: June 2024

Over the last decades, nanoparticles have been increasingly used in biomedical applications, such as immunolabelling, requiring high control over size and shape. Nanoparticle synthesis often lacks the required reaction control which necessitates additional purification steps. For this purpose, asymmetric flow field flow fractionation (AFFF) is a powerful tool to purify particles and characterize them online. Here, we systematically studied the usability of AFFF for the purification of a colloid primarily containing self-assembled Au/Au core/satellite particles (C/S particles). In this case, purification of C/S particles from unbound monomeric AuNP satellites, which were added in excess during synthesis, is needed. We successfully demonstrated the effective separation of monomeric SERS-inactive AuNP satellites from the highly SERS-active C/S particles. While centrifugation is a commonly used and easy bench-top method, separation with AFFF offers an improved resolution and recovery. A linearly decreasing crossflow profile enabled us to achieve a separation with sufficient resolution and good recovery. Purified C/S colloids exhibit an increase in SERS activity of 25%, improving their usability for SERS-based applications by avoiding false-negative results.
Biomimetic total synthesis and paired omics identify an intermolecular Diels-Alder reaction as the key step in lugdunomycin biosynthesis
Authors: Uiterweerd Michiel T. , Nunez Santiago Isabel , Havenith Remco , Du Chao , Zhang Le , van der Heul Helga , Elsayed Somayah , Minnaard Adri , van Wezel Gilles
Published: June 2024

Microbial natural products are the basis of the majority of the clinical drugs, such as antibiotics, anticancer agents, antifungals and immunosuppressants. The sharp rise in antimicrobial resistance (AMR) requires new ways to replenish the drug-discovery pipelines, whereby the discovery of truly novel structural scaffolds is a major challenge. Lugdunomycin is a highly rearranged angucycline polyketide produced by Streptomyces sp. QL37, but the later stages of its biosynthesis so far remained elusive. Here, using combined biomimetic chemical synthesis, computational methods, genomics and mutational analysis, we shed important new light on the biosynthesis of a molecule with highly complex chemical scaffold. We show that lugdunomycin is formed by a rare intermolecular Diels-Alder reaction, with elmonin as a masked diene and iso-maleimycin as dienophile. The biosynthesis of the two substrates is encoded by distinct biosynthetic gene clusters (BGCs), whereby elmonin is specified by an angucycline BGC, while the biosynthesis of iso-maleimycin is encoded by a BGC for a β-lactone-like compound. Biomimetic total synthesis of lugdunomycin showed that the Diels-Alder reaction leads to the production of a diastereomer of lugdunomycin as the main product in vitro. The diastereomeric ratio of the in vitro Diels-Alder reaction shifted towards lugdunomycin in the presence of proteinaceous material, suggesting that the in vivo Diels-Alder reaction is templated. The requirement of distinct biosynthetic pathways and complex chemical reactions indicate the challenges we face in discovering new chemical space.