bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing
Authors: Hart Martin , Nolte Elke , Wach Sven , Szczyrba Jaroslaw , Taubert Helge , Rau Tilman T. , Hartmann Arndt , Grässer Friedrich A. , Wullich Bernd
Published: April 2023

PDF file - 26K, Clinicopathological characteristics of prostate carcinoma samples used for Illumina sequencing and qRT-PCR validation of the sequencing. The clinicopathological characteristics of the patient set used for deep sequencing are given in the left column. The properties of the sample set used for qRT-PCR are summarized on the right side.
Supplementary Figure 4 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing
Authors: Hart Martin , Nolte Elke , Wach Sven , Szczyrba Jaroslaw , Taubert Helge , Rau Tilman T. , Hartmann Arndt , Grässer Friedrich A. , Wullich Bernd
Published: April 2023

PDF file - 175K, The relative expression of SEC23A, PHLPP1 and PHLPP2 determined by qRT-PCR. (A-C) The relative expression of SEC23A, PHLPP1, and PHLPP2 mRNA was analyzed by qRT-PCR in a patient set of 40 pairs of normal and corresponding pT2 (N0), pT3 (N0) and lymph node metastasizing (pN1) PCa tissues.
Supplementary Figure 2 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing
Authors: Hart Martin , Nolte Elke , Wach Sven , Szczyrba Jaroslaw , Taubert Helge , Rau Tilman T. , Hartmann Arndt , Grässer Friedrich A. , Wullich Bernd
Published: April 2023

PDF file - 175K, qRT-PCR analysis of miRNAs found deregulated by sequencing. 40 paired samples of prostate carcinoma and the corresponding non-tumor tissues were analyzed by qRT-PCR. In the overall comparison, the changes in miR-20a, -143, -145, -148a, -200b and -375 were statistically significant. MiR-15a and let7c revealed no significant change.
Supplementary Figure 3 from Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy
Authors: Schneider Gabriela , Bryndza Ewa , Abdel-Latif Ahmed , Ratajczak Janina , Maj Magdalena , Tarnowski Maciej , Klyachkin Yuri M. , Houghton Peter , Morris Andrew J. , Vater Axel , Klussmann Sven , Kucia Magdalena , Ratajczak Mariusz Z.
Published: April 2023

Supplementary Figure 3 - PDF file 66K, S1P and C1P levels create a pro-metastatic microenvironment in organs after administration of vincristine
Supplementary Figures 1 - 3 from HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS
Authors: Yang Moon Hee , Laurent Gaelle , Bause Alexandra S. , Spang Robert , German Natalie , Haigis Marcia C. , Haigis Kevin M.
Published: April 2023

PDF file - 194K, S1. Validation of knockdowns. S2. Regulation of K-RAS acetylation and oncogenicity by HDAC1/6. S3. SIRT2 regulates K-RAS acetylation and oncogenicity.
Supplementary Figure Legends from PPP2R2C Loss Promotes Castration-Resistance and Is Associated with Increased Prostate Cancer-Specific Mortality
Authors: Bluemn Eric G. , Spencer Elysia Sophie , Mecham Brigham , Gordon Ryan R. , Coleman Ilsa , Lewinshtein Daniel , Mostaghel Elahe , Zhang Xiaotun , Annis James , Grandori Carla , Porter Christopher , Nelson Peter S.
Published: April 2023

PDF, 54K.
Supplemental Table 13 from Expression of ANRIL–Polycomb Complexes–CDKN2A/B/ARF Genes in Breast Tumors: Identification of a Two-Gene (EZH2/CBX7) Signature with Independent Prognostic Value
Authors: Meseure Didier , Vacher Sophie , Alsibai Kinan Drak , Nicolas Andre , Chemlali Walid , Caly Martial , Lidereau Rosette , Pasmant Eric , Callens Celine , Bieche Ivan
Published: April 2023

ANRIL pathway genes mRNA levels in the 4 breast tumor subtypes in the series of 456 breast tumors.
Supplemental Figures 1-5 from A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function
Authors: Menezes Daniel L. , Holt Jenny , Tang Yan , Feng Jiajia , Barsanti Paul , Pan Yue , Ghoddusi Majid , Zhang Wei , Thomas George , Holash Jocelyn , Lees Emma , Taricani Lorena
Published: April 2023

Supplemental Figures 1-5. Supplemental Figure 1. Kinase selectivity profile of ATRi. Supplemental Figure 2. Screening of inhibitors in cellular γ-H2AX assay in U2OS cells. Supplemental Figure 3. Flow cytometry profiles assessing γ-H2AX response to compare antimetabolite combinations with a fixed concentration of ATRi in U2OS cells. Supplemental Figure 4. γ-H2AX response and cell viability following ATRi treatment in U2OS cells. Supplemental Figure 5. In vivo pharmacokinetics and γ-H2AX pharmacodynamics of ATRi in GRANTA-519 (ATM mut) MCL tumor xenograft model.
Supplementary Information from The Efflux Transporter ABCG2 Maintains Prostate Stem Cells
Authors: Sabnis Neha G. , Miller Austin , Titus Mark A. , Huss Wendy J.
Published: April 2023

S1. Growth Curves and DHT metabolism in the HPr-1-AR and CWR-R1 cells. S2. ABCG2 effluxes androgens. S3. ABCG2-expressing cells enrich for stem cell markers.
Supplemental Methods, Figures, Tables from Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1
Authors: Kent Oliver A. , Mendell Joshua T. , Rottapel Robert
Published: April 2023

Supplemental Figure 1. (A) Taqman qPCR analysis of miR-31 expression in RNA isolated from isogenic HCT116 cell lines with oncogenic KRAS (mut/null) or with wild-type KRAS (wt/null). (B) qPCR analysis of KRAS expression in the indicated cell lines transfected with siRNA control [-] or siRNA against KRAS [+]. Expression was normalized to -actin mRNA. Supplemental Figure 2. Quantitative PCR analysis of ELK1 and GAPDH expression in Panc-1 cells transfected with control siRNAs (siCon) or siRNA targeting GAPDH (siGAPDH) or ELK1 (siELK1). Expression was normalized to -actin mRNA. Supplemental Figure 3. Comparison of endogenous miR-31 expression in HNPE-KRAS cells to the indicated PDAC cells lines infected with MSCV-empty vector (EV) or MSCV-miR-31 (miR-31). MiR-31 was detected by Taqman qPCR and normalized to U6 snRNA. Supplemental Figure 4. (A) Growth rates of BxPc3, Capan-1 and MiaPaCa2 cell lines infected with MSCV-empty vector (EV) or MSCV-miR-31 (miR-31) monitored over the indicated time course. Rate of growth measured by MTT assay (BxPc3) or percent confluency (Capan-1 and MiaPaCa2). (B) Western blot analysis of lysates from non-stimulated [-] or FBS stimulated [+] MiaPaCa2 and Capan-1 cell lines stably transfected with MSCV-empty vector (EV) or MSCV-miR- 31 (miR-31). pERK and ERK indicate phosphorylated and total ERK. pAKT and AKT indicate phosphorylated and total AKT, respectively. Supplemental Figure 5. Western blot analysis of RASA1 expression in isogenic HCT116 cells. Tubulin served as a protein loading control. Supplemental Figure 6. (A) Western blot analysis of lysates from non-stimulated [-] or FBS stimulated [+] MiaPaCa2 and Capan-1 cell lines transfected with control siRNA (siCon) or siRNA targeting RASA1 (siRASA1). pERK and ERK indicate phosphorylated and total ERK. pAKT and AKT indicate phosphorylated and total AKT, respectively. (B) Western blot analysis of flag- RASA1 expression in Panc-1 cells transfected with CMV-empty vector (EV) or CMV-flag-RASA1 (RASA1). Tubulin served as a protein loading control. Supplemental Table 1: Primer sequences. A list of all primers used in the study and their respective applications. Supplemental Table 2: ConSite analysis of transcription factor binding elements in the miR-31 promoter. Shown is a list of TF binding elements within the miR-31 proximal promoter. Transcription factors were analyzed for known involvement in KRAS-MAPK pathway. Supplemental Table 3: Analysis of potential miR-31 target genes. Shown are the 18 target genes from the intersection of 4 prediction algorithms and the representative number of conserved and non-conserved miR-31 binding sites (from Targetscan). Supplemental Table 4: Literature analysis of miR-31 invasion-migration publications.
Figure S1 from The Microtubule Network and Cell Death Are Regulated by an miR-34a/Stathmin 1/βIII-Tubulin Axis
Authors: Vetter Nancy S. , Kolb E.A. , Mills Christopher C. , Sampson Valerie B.
Published: April 2023

RT-qPCR measurements of miR-34a in SaOS and 143B cells transfected with non-targeting miR-C (control) oligonucleotides or miR-34a mimics.
Supplementary Figure 4 from Fhit Regulates EMT Targets through an EGFR/Src/ERK/Slug Signaling Axis in Human Bronchial Cells
Authors: Joannes Audrey , Grelet Simon , Duca Laurent , Gilles Christine , Kileztky Claire , Dalstein Véronique , Birembaut Philippe , Polette Myriam , Nawrocki-Raby Béatrice
Published: April 2023

PDF file - 108KB, Supplementary figure 4: Effect of pharmacological inhibitors of various signaling pathways on cell invasion induced by Fhit silencing. HBE4-E6/E7 cells were transfected with scrambled or Fhit siRNA as described in the "Materials and Methods" section. The invasive capacities of the transfectants were tested in a modified Boyden chamber invasion assay in the presence of PD98059 (ERK), PP1 (Src), SB203580 (p38), Y27632 (ROCK), KT5720 (PKA), wortmaninn (PI3K), U73122 (PLC) or SP600125 (JNK) inhibitors. A representative experiment is shown. Data are expressed as fold induction relative to the DMSO control. *P < 0.05.
Supplementary figures 1-5 from Oxidative Stress–Induced Protein Damage Inhibits DNA Repair and Determines Mutation Risk and Therapeutic Efficacy
Authors: McAdam Elizabeth , Brem Reto , Karran Peter
Published: April 2023

S1. Gel loading control for carbonyl visualization. S2. HaCaT cell survival as a function of CPDs. S3. NER in UVA-treated HeLa cells. S4. RPA overexpression in U2OS-RPA21 cells protects NER against inhibition by UVA. S5. The effect of IDH R132 inhibition on NER in HT1080 chondrosarcoma cells.
Supplementary Table 2 from Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity
Authors: Aggarwal Rahul R. , Quigley David A. , Huang Jiaoti , Zhang Li , Beer Tomasz M. , Rettig Matthew B. , Reiter Rob E. , Gleave Martin E. , Thomas George V. , Foye Adam , Playdle Denise , Lloyd Paul , Chi Kim N. , Evans Christopher P. , Lara Primo N. , Feng Felix Y. , Alumkal Joshi J. , Small Eric J.
Published: April 2023

Supplementary Table 2. Clinical Characteristics of the Evaluable Paired Biopsy Cohort
Supplementary Figure 3 from Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer
Authors: Nguyen Dan J.M. , Theodoropoulos George , Li Ying-Ying , Wu Chunjing , Sha Wei , Feun Lynn G. , Lampidis Theodore J. , Savaraj Niramol , Wangpaichitr Medhi
Published: April 2023

Growth Inhibitory effect of cisplatin.
Supplementary Table 6 from Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma
Authors: Tworkoski Kathryn , Singhal Garima , Szpakowski Sebastian , Zito Christina Ivins , Bacchiocchi Antonella , Muthusamy Viswanathan , Bosenberg Marcus , Krauthammer Michael , Halaban Ruth , Stern David F.
Published: April 2023

Supplementary Table 6 from Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma
Supplementary Figure 6 from miR-31 Is a Broad Regulator of β1-Integrin Expression and Function in Cancer Cells
Authors: Augoff Katarzyna , Das Mitali , Bialkowska Katarzyna , McCue Brian , Plow Edward F. , Sossey-Alaoui Khalid
Published: April 2023

PDF file - 19K
Supplementary Figures 1-2 from Lysophosphatidic Acid–Induced p21Waf1 Expression Mediates the Cytostatic Response of Breast and Ovarian Cancer Cells to TGFβ
Authors: Wu Jinhua , Mukherjee Abir , Lebman Deborah A. , Fang Xianjun
Published: April 2023

PDF file - 90K
Supplementary Data from The TRC8 Ubiquitin Ligase Is Sterol Regulated and Interacts with Lipid and Protein Biosynthetic Pathways
Authors: Lee Jason P. , Brauweiler Anne , Rudolph Michael , Hooper Joan E. , Drabkin Harry A. , Gemmill Robert M.
Published: April 2023

Supplementary Data from The TRC8 Ubiquitin Ligase Is Sterol Regulated and Interacts with Lipid and Protein Biosynthetic Pathways
Supplementary Figures 1-3 from Clusterin Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer
Authors: Shiota Masaki , Zoubeidi Amina , Kumano Masafumi , Beraldi Eliana , Naito Seiji , Nelson Colleen C. , Sorensen Poul H.B. , Gleave Martin E.
Published: April 2023

PDF file - 160K
Supplementary Fig 1 from Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma
Authors: Dey Sanchareeka , Ashrafi Adnin , Vidal Chantal , Jain Nivesh , Kalainayakan Sarada Preeta , Ghosh Poorva , Alemi Parinaz Sadat , Salamat Narges , Konduri Purna Chaitanya , Kim Jung-whan , Zhang Li
Published: April 2023

Supplementary Figure 1. The levels of proteins and enzyme subunits involved in OXPHOS and glutamine metabolism increase with lung tumor progression. A, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the OXPHOS protein HCCS. B, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the glutamine transporter SLC1A5. C, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of GLS. Shown are montage images of lung tissue sections stained with H&E (row 1), montage images stained with DAPI (row 2) or antibodies against the indicated protein (row 3), and 10X images of lung tissue sections stained with DAPI (row 4) or antibodies against the indicated protein (row 5). The light green lines in DAPI montage images outline the tumors in the lung. The blue rectangles in H&E and white rectangles in DAPI montage images denote the regions shown in 10X. Scale bar, montage, 1mm; 4X, 200 Âµm; 10X, 100Âµm. D, Graph showing quantified levels of HCCS correlating with A. E, Graph showing quantified levels of SLC1A5 correlating with B. F, Graph showing quantified levels of GLS correlating with C. Protein levels were quantified, and data are plotted as mean {plus minus} SEM. G, Representative 40X IHC images of lung tissue sections showing the co-localization of ATP5F1A, COX7B, and CYCS with the mitochondrial marker TOMM20. Scale bar, 10 Âµm. H, OCR of NSCLC H226 cells cultured in normal medium, or heme depleted medium with 0.5 mM succinyl acetone (HD+SA). Heme (5 ÂµM, 10 ÂµM, and 20 ÂµM, respectively) was added back to examine the effects of heme on OCRs. For statistical analysis, the levels in cells with heme added back were compared with the levels in cells without heme added back with a Welch two-sample t test. **, P<0.005.
Table S2 from Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1
Authors: Calvo Jennifer A. , Fritchman Briana , Hernandez Desiree , Persky Nicole S. , Johannessen Cory M. , Piccioni Federica , Kelch Brian A. , Cantor Sharon B.
Published: April 2023

Functional prediction of FANCJ mutations by Mutation Assessor
Table S1 from Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1
Authors: Calvo Jennifer A. , Fritchman Briana , Hernandez Desiree , Persky Nicole S. , Johannessen Cory M. , Piccioni Federica , Kelch Brian A. , Cantor Sharon B.
Published: April 2023

Information on FANCJ mutation library, including source of mutation
Supplementary Data 1-4 from Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance
Authors: Cotter Kellie A. , Gallon John , Uebersax Nadine , Rubin Philip , Meyer Kate D. , Piscuoglio Salvatore , Jaffrey Samie R. , Rubin Mark A.
Published: April 2023

Supplementary Data 1. Number of m6A sites identified by miCLIP in LNCaP cells Supplementary Data 2. Number of m6A sites identified by miCLIP in RWPE cells Supplementary Data 3. Differentially expressed proteins (adjusted P-value < 0.05) with METTL3 knockdown as determined by mass spectrometry Supplementary Data 4. Differentially expressed genes (adjusted P-value < 0.05) with METTL3 knockdown and 10 µM enzalutamide treatment as determined by RNA-seq
Figure S7 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Fig. S7 Expression of miR-146a in GEO Profiles database: GSE23806
Supplementary Figures 1-4 from IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability
Authors: Leone Marina , Cazorla-Vázquez Salvador , Ferrazzi Fulvia , Wiederstein Janica L. , Gründl Marco , Weinstock Grit , Vergarajauregui Silvia , Eckstein Markus , Krüger Marcus , Gaubatz Stefan , Engel Felix B.
Published: April 2023

Figure S1: IQGAP3 depletion does not affect apoptotic HeLa rate but affects cell proliferation. Figure S2: Efficiency of siRNA-mediated YAP/TAZ and B-MYB knockdown strategy in HeLa cells. Figure S3: IQGAP3 knockdown strategy in Hct116 cells. Figure S4: IQGAP3 binds to both Cdk11p58 and uMAP4.
Figure S3 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Fig. S3 miR-146a inhibits cell proliferation and invasion in established GBM cell lines
Supplementary Data from Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma
Authors: Li Deng-Ke , Chen Xing-Rui , Wang Li-Na , Wang Jia-Hong , Wen Yue-Ting , Zhou Zi-Ying , Li Ji-Ke , Liu Jing-Xian , Cai Lin-Bo , Zhong Shui-Sheng , Lyu Xiao-Ming , Damola Faleti Oluwasijibomi , Li Min-Ying , Zhang Jing-Jing , Zeng Yu-Mei , Wang Qian-Li , Zhang Qian-Bing , Lyu Hao , Fu Xiao-Yan , Wang Wei , Li Xin , Huang Zhong-Xi , Yao Kai-Tai
Published: April 2023

Supplementary Data
Supplementary Table 1 from Heterogeneity and Cancer-Related Features in Lymphangioleiomyomatosis Cells and Tissue
Authors: Espín Roderic , Baiges Alexandra , Blommaert Eline , Herranz Carmen , Roman Antonio , Saez Berta , Ancochea Julio , Valenzuela Claudia , Ussetti Piedad , Laporta Rosalía , Rodríguez-Portal José A. , van Moorsel Coline H.M. , van der Vis Joanne J. , Quanjel Marian J.R. , Villar-Piqué Anna , Diaz-Lucena Daniela , Llorens Franc , Casanova Álvaro , Molina-Molina María , Plass Mireya , Mateo Francesca , Moss Joel , Pujana Miquel Angel
Published: April 2023

Table S1. A, Publication references for LAMp genes/proteins. B, Cancer cell lines (identifier, n, and cancer type) used in the clustering analysis with LAM scRNA-seq cell profiles. C, Clinical information about individuals included in plasma studies.
Supplementary Tables 1-6 from Distinct Genomic Alterations in Prostate Tumors Derived from African American Men
Authors: Liu Wennuan , Zheng S. Lilly , Na Rong , Wei Lin , Sun Jishan , Gallagher Johnie , Wei Jun , Resurreccion W. Kyle , Ernst Sarah , Sfanos Karen S. , Isaacs William B. , Xu Jianfeng
Published: April 2023

Supplementary Table 1. Gleason grade and TNM stage of the tumors from 83 African American men. Supplementary Table 2. Somatic exon mutations identified by Mutect2 in tumors of 77 AA men. Supplementary Table 3. Performance of the Agilent SureSelect and NimbleGen SeqCap enrichment. Supplementary Table 4. Frequency of exon somatic mutations in targeted 39 genes among 77 AA tumors. Supplementary Table 5. Number of EA/white and AA/black patients in different cohorts used for analysis of DNA copy number alterations. Supplementary Table 6. Comparing the frequency of 13 most common CNAs in EA/white and AA/black PCa.
Supplementary Figure 5 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase
Authors: Ginzel Joshua D. , Acharya Chaitanya R. , Lubkov Veronica , Mori Hidetoshi , Boone Peter G. , Rochelle Lauren K. , Roberts Wendy L. , Everitt Jeffrey I. , Hartman Zachary C. , Crosby Erika J. , Barak Lawrence S. , Caron Marc G. , Chen Jane Q. , Hubbard Neil E. , Cardiff Robert D. , Borowsky Alexander D. , Lyerly H. Kim , Snyder Joshua C.
Published: April 2023

TruRegistry of HER2BOW tissues
Supplementary Figure 6 from NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells
Authors: Jilishitz Irina , Quiñones Jason Luis , Patel Priyank , Chen Grace , Pasetsky Jared , VanInwegen Allison , Schoninger Scott , Jogalekar Manasi P. , Tsiperson Vladislav , Yan Lingyue , Wu Yun , Gottesman Susan R.S. , Somma Jonathan , Blain Stacy W.
Published: April 2023

Phase 1, 2, and 3 studies
Supplementary Figure 1L-W from NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells
Authors: Jilishitz Irina , Quiñones Jason Luis , Patel Priyank , Chen Grace , Pasetsky Jared , VanInwegen Allison , Schoninger Scott , Jogalekar Manasi P. , Tsiperson Vladislav , Yan Lingyue , Wu Yun , Gottesman Susan R.S. , Somma Jonathan , Blain Stacy W.
Published: April 2023

ALT treatment does not cause apoptosis or autophagy
Supplementary Table 3 from SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation
Authors: Adolphe Christelle , Millar Amanda , Kojic Marija , Barkauskas Deborah S. , Sundström Anders , Swartling Fredrik J. , Hediyeh-zadeh Soroor , Tan Chin Wee , Davis Melissa J. , Genovesi Laura A. , Wainwright Brandon J.
Published: April 2023

Medulloblastoma and granule cell precursor Gli1 target genes
Figure S5 from Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression
Authors: Alzofon Nathaniel , Koc Katrina , Panwell Kristin , Pozdeyev Nikita , Marshall Carrie B. , Albuja-Cruz Maria , Raeburn Christopher D. , Nathanson Katherine L. , Cohen Debbie L. , Wierman Margaret E. , Kiseljak-Vassiliades Katja , Fishbein Lauren
Published: April 2023

β-catenin interacts with dEx1 MAML3. Neuroendocrine tumor cell lines were co-transfected with β-catenin and dEx1 MAML3. Immunoprecipitation of MAML3 demonstrated co-precipitation of Î²-catenin in QGP-1 and BON-1, but not in SK-N-SH (not shown). Blot represents one of three separate experiments.
Supplementary Table 1 from SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation
Authors: Adolphe Christelle , Millar Amanda , Kojic Marija , Barkauskas Deborah S. , Sundström Anders , Swartling Fredrik J. , Hediyeh-zadeh Soroor , Tan Chin Wee , Davis Melissa J. , Genovesi Laura A. , Wainwright Brandon J.
Published: April 2023

Sox9 immunostaining pattern in a variety of Shh-MB genetic mouse models
Supplementary Table 4 from MicroRNA-324-5p–CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness
Authors: Ghatak Dishari , Datta Arindam , Roychowdhury Tanaya , Chattopadhyay Samit , Roychoudhury Susanta
Published: April 2023

Supplementary Table 4: TCGA
Supplementary Method from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

Whole-exome sequencing and analysis of CTC-DNA.
Supplementary Table 2 from TWEAK–Fn14–RelB Signaling Cascade Promotes Stem Cell–like Features that Contribute to Post-Chemotherapy Ovarian Cancer Relapse
Authors: Holmberg Ryne , Robinson Mikella , Gilbert Samuel F. , Lujano-Olazaba Omar , Waters Jennifer A. , Kogan Emily , Velasquez Candyd Lace R. , Stevenson Denay , Cruz Luisjesus S. , Alexander Logan J. , Lara Jacqueline , Mu Emily M. , Camillo Jared Rafael , Bitler Benjamin G. , Huxford Tom , House Carrie D.
Published: April 2023

Reagent and Manufacturer Order Information.
Supplementary Figure 1 from TWEAK–Fn14–RelB Signaling Cascade Promotes Stem Cell–like Features that Contribute to Post-Chemotherapy Ovarian Cancer Relapse
Authors: Holmberg Ryne , Robinson Mikella , Gilbert Samuel F. , Lujano-Olazaba Omar , Waters Jennifer A. , Kogan Emily , Velasquez Candyd Lace R. , Stevenson Denay , Cruz Luisjesus S. , Alexander Logan J. , Lara Jacqueline , Mu Emily M. , Camillo Jared Rafael , Bitler Benjamin G. , Huxford Tom , House Carrie D.
Published: April 2023

TWEAK and Fn14 are associated with worse outcomes in ovarian cancer.
Supplementary Data from Plasticity within Aldehyde Dehydrogenase–Positive Cells Determines Prostate Cancer Radiosensitivity
Authors: Schwarz Franziska M. , Schniewind Iñaki , Besso Maria J. , Lange Steffen , Linge Annett , Patil Shivaprasad G. , Löck Steffen , Klusa Daria , Dietrich Antje , Voss-Böhme Anja , Nowrouzi Ali , Krause Mechthild , Dubrovska Anna , Kurth Ina , Peitzsch Claudia
Published: April 2023

Supplementary Data from Plasticity within Aldehyde Dehydrogenase–Positive Cells Determines Prostate Cancer Radiosensitivity
Supplementary Data Figures 1 - 7, Supplementary Methods from Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair
Authors: Dow Jonathan , Krysztofiak Adam , Liu Yanfeng , Colon-Rios Daniel A. , Rogers Faye A. , Glazer Peter M.
Published: April 2023

SFig 1: SAHA reduces H3K9 trimethylation in IDH1 mutant cells while increasing H3K9 and H4 acetylation, SFig 2: Characterization of U2OS EJDR cells after SAHA, metabolite and siRNA treatment, SFig 3: SAHA elevates DNA damage to a greater degree in IDH1 mutant cells, comparable to BRCA1 and RAD51 siRNA knockdown, SFig 4: SAHA represses RAD51 and increases γ-H2AX foci formation, SFig 5: Mutant IDH1 sensitivity to PARPi treatment, SFig 6: Synergy of SAHA combination with radiation, TMZ and PARPi, SFig 7: SAHA down-regulates HDR factor expression, elevates DNA damage and has greater effect alone and plus PARPi against IDH1 mutant HCT116 cells
Data from ADAM Metallopeptidase Domain 12 Facilitates Colorectal Cancer Progression by Inhibiting Hippo Signaling Pathway Activity
Authors: Wang XiaoPeng , Zhu Mo , Zuo Hao , Hou Guowei , Xie Rui
Published: April 2023

Abstract
This work focused on investigating the effect of A Disintegrin And Metalloproteases 12 (ADAM12) on colorectal cancer development. ADAM12 levels within colorectal cancer samples were analyzed by using The Cancer Genome Atlas (TCGA) database. Then, altogether 55 patients with colorectal cancer were enrolled to detect ADAM12 expression. ADAM12 overexpression or knockdown was transfected into colorectal cancer cells. Thereafter, this work examined colorectal cancer cell viability through Cell Counting Kit-8 (CCK-8) and cell clone forming assays. Meanwhile, nude mice were utilized for in vivo analysis. Transwell assays were conducted for detecting migration and invasion of colorectal cancer cells. In addition, mRN and protein expression was analyzed through qRT-PCR, Western blotting (WB) together with IHC staining. As a result, ADAM12 and YAP1 expression increased among colorectal cancer cases, and it indicated the dismal prognostic outcome of patients. Furthermore, ADAM12 promoted colorectal cancer cell growth, migration, invasion along with in vivo growth. ADAM12 suppressed p-MST1/MST1, p-LATS1/LATS1 together with p-YAP1 protein levels within colorectal cancer cells. ADAM12 increased YAP1 and TAZ protein levels as well as CTGF, Cyr61, and Birc5 mRNA expression in colorectal cancer cells. YAP1 inhibitor administration counteracted ADAM12’s function in promoting colorectal cancer cell growth, migration, invasion, and increasing CTGF, Cyr61, and Birc5 expression.
Implications:
Our study indicates that ADAM12 facilitates colorectal cancer progression through suppressing Hippo pathway activity, and that ADAM12 is the candidate therapeutic target and prognostic biomarker for patients with colorectal cancer.
Data from TBX3 Promotes Cervical Cancer Proliferation and Migration via HPV E6 and E7 Signaling
Authors: Khan Saif F. , Burmeister Carly A. , Scott David J. , Sinkala Musalula , Ramburan Amsha , Wu Hue-Tsi , Schäfer Georgia , Katz Arieh A. , Prince Sharon
Published: April 2023

Abstract
Cervical cancer is a leading cause of cancer-related deaths in women globally and 99% of cases are caused by persistent infection with high-risk strains of the human papillomavirus (HPV). The HPV oncoproteins E6 and E7 establish the cancer phenotype by cooperating with host proteins and identifying them may have important therapeutic benefits. T-box transcription factor 3 (TBX3) is a critical developmental regulator, and when it is overexpressed postnatally, it contributes to several cancers, but little is known about its expression and role in cervical cancer. The current study shows that TBX3 is upregulated in cervical cancer cell lines as well as precancerous and cervical cancer patient tissue and is associated with larger and more invasive tumors. Knockdown and overexpression cell culture models show that TBX3 promotes HPV-positive cell proliferation, migration, and spheroid growth; however, TBX3 inhibits these processes in HPV-negative cells. Importantly, we show that the tumor promoting activity of TBX3 in cervical cancer is dependent on E6/E7.
Implications:
In summary, our study highlights the importance of TBX3 as a cooperating partner of E6/E7 in HPV-positive cervical cancer and identifies TBX3 as a potential therapeutic target to treat this neoplasm.
Data from Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response
Authors: Storey Claire M. , Altai Mohamed , Bicak Mesude , Veach Darren R. , Lückerath Katharina , Adrian Gabriel , McDevitt Michael R. , Kalidindi Teja , Park Julie E. , Herrmann Ken , Abou Diane , Zedan Wahed , Peekhaus Norbert , Klein Robert J. , Damoiseaux Robert , Larson Steven M. , Lilja Hans , Thorek Daniel , Ulmert David
Published: April 2023

Abstract
Noninvasive biomarkers for androgen receptor (AR) pathway activation are urgently needed to better monitor patient response to prostate cancer therapies. AR is a critical driver and mediator of resistance of prostate cancer but currently available noninvasive prostate cancer biomarkers to monitor AR activity are discordant with downstream AR pathway activity. External beam radiotherapy (EBRT) remains a common treatment for all stages of prostate cancer, and DNA damage induced by EBRT upregulates AR pathway activity to promote therapeutic resistance. [89Zr]11B6-PET is a novel modality targeting prostate-specific protein human kallikrein 2 (hK2), which is a surrogate biomarker for AR activity. Here, we studied whether [89Zr]11B6-PET can accurately assess EBRT-induced AR activity.

Genetic and human prostate cancer mouse models received EBRT (2–50 Gy) and treatment response was monitored by [89Zr]11B6-PET/CT. Radiotracer uptake and expression of AR and AR target genes was quantified in resected tissue.

EBRT increased AR pathway activity and [89Zr]11B6 uptake in LNCaP-AR and 22RV1 tumors. EBRT increased prostate-specific [89Zr]11B6 uptake in prostate cancer–bearing mice (Hi-Myc x Pb_KLK2) with no significant changes in uptake in healthy (Pb_KLK2) mice, and this correlated with hK2 protein levels.
Implications:
hK2 expression in prostate cancer tissue is a proxy of EBRT-induced AR activity that can noninvasively be detected using [89Zr]11B6-PET; further clinical evaluation of hK2-PET for monitoring response and development of resistance to EBRT in real time is warranted.
Supplementary Figure 3 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Authors: Morey Kinney Shannon R. , Zhang Wa , Pascual Marien , Greally John M. , Gillard Bryan M. , Karasik Ellen , Foster Barbara A. , Karpf Adam R.
Published: April 2023

Supplementary Figure 3 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Supplementary Figure 2 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Authors: Morey Kinney Shannon R. , Zhang Wa , Pascual Marien , Greally John M. , Gillard Bryan M. , Karasik Ellen , Foster Barbara A. , Karpf Adam R.
Published: April 2023

Supplementary Figure 2 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Perspective on this Article from Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression
Authors: Li Xiaohong , Galipeau Patricia C. , Sanchez Carissa A. , Blount Patricia L. , Maley Carlo C. , Arnaudo Jessica , Peiffer Daniel A. , Pokholok Dmitry , Gunderson Kevin L. , Reid Brian J.
Published: April 2023

Perspective on this Article from Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression
Perspective from Estimating Rates of True High-Grade Disease in the Prostate Cancer Prevention Trial
Authors: Pinsky Paul , Parnes Howard , Ford Leslie
Published: April 2023

Perspective from Estimating Rates of True High-Grade Disease in the Prostate Cancer Prevention Trial
Supplementary Figure Legends 1-3 from Aerosolized 3-Bromopyruvate Inhibits Lung Tumorigenesis without Causing Liver Toxicity
Authors: Zhang Qi , Pan Jing , North Paula E. , Yang Shoua , Lubet Ronald A. , Wang Yian , You Ming
Published: April 2023

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Supplementary Table Legend from Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth
Authors: Lee Mee-Hyun , Huang Zunnan , Kim Dong Joon , Kim Sung-Hyun , Kim Myoung Ok , Lee Sung-Young , Xie Hua , Park Si Jun , Kim Jae Young , Kundu Joydeb Kumar , Bode Ann M. , Surh Young-Joon , Dong Zigang
Published: April 2023

PDF file - 52K
Supplementary Figure Legend from Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth
Authors: Lee Mee-Hyun , Huang Zunnan , Kim Dong Joon , Kim Sung-Hyun , Kim Myoung Ok , Lee Sung-Young , Xie Hua , Park Si Jun , Kim Jae Young , Kundu Joydeb Kumar , Bode Ann M. , Surh Young-Joon , Dong Zigang
Published: April 2023

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Supplementary Table 1 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
Authors: Oyama Takeru , Yasui Yumiko , Sugie Shigeyuki , Koketsu Mamoru , Watanabe Kunitomo , Tanaka Takuji
Published: April 2023

Supplementary Table 1 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
Supplementary Figure 4 from Identification of Actively Translated mRNA Transcripts in a Rat Model of Early-Stage Colon Carcinogenesis
Authors: Davidson Laurie A. , Wang Naisyin , Ivanov Ivan , Goldsby Jennifer , Lupton Joanne R. , Chapkin Robert S.
Published: April 2023

Supplementary Figure 4 from Identification of Actively Translated mRNA Transcripts in a Rat Model of Early-Stage Colon Carcinogenesis
Related Article from Walking the Walk from Genes through Telomere Maintenance to Cancer Risk
Authors: Blackburn Elizabeth H.
Published: April 2023

Related Article from Walking the Walk from Genes through Telomere Maintenance to Cancer Risk
Supplementary Figures 1-3 from Caffeic Acid Phenethyl Ester Suppresses the Proliferation of Human Prostate Cancer Cells through Inhibition of p70S6K and Akt Signaling Networks
Authors: Chuu Chih-Pin , Lin Hui-Ping , Ciaccio Mark F. , Kokontis John M. , Hause Ronald J. , Hiipakka Richard A. , Liao Shutsung , Jones Richard Baker
Published: April 2023

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Supplementary Figures S1 and S2 from Effects of the Kava Chalcone Flavokawain A Differ in Bladder Cancer Cells with Wild-type versus Mutant p53
Authors: Tang Yaxiong , Simoneau Anne R. , Xie Jun , Shahandeh Babbak , Zi Xiaolin
Published: April 2023

Supplementary Figures S1 and S2 from Effects of the Kava Chalcone Flavokawain A Differ in Bladder Cancer Cells with Wild-type versus Mutant p53
Two Perspectives on this Article from Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model
Authors: Czerninski Rakefet , Amornphimoltham Panomwat , Patel Vyomesh , Molinolo Alfredo A. , Gutkind J. Silvio
Published: April 2023

Two Perspectives on this Article from Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model
Supplementary Tables 1 - 3 from Increased Levels of Urinary PGE-M, a Biomarker of Inflammation, Occur in Association with Obesity, Aging, and Lung Metastases in Patients with Breast Cancer
Authors: Morris Patrick G. , Zhou Xi Kathy , Milne Ginger L. , Goldstein Daniel , Hawks Laura C. , Dang Chau T. , Modi Shanu , Fornier Monica N. , Hudis Clifford A. , Dannenberg Andrew J.
Published: April 2023

PDF file - 76K, Additional Patient Characteristics.
Supplementary Figure 1 from All-Trans Retinoic Acid Suppresses Stat3 Signaling during Skin Carcinogenesis
Authors: Syed Zanobia , Cheepala Satish B. , Gill Jennifer N. , Stein Jennica , Nathan Cherie Ann , DiGiovanni John , Batra Vinita , Adegboyega Patrick , Kleiner Heather E. , Clifford John L.
Published: April 2023

Supplementary Figure 1 from All-Trans Retinoic Acid Suppresses Stat3 Signaling during Skin Carcinogenesis
Supplementary Figure 2B from Mortality in the Randomized, Controlled Lung Intergroup Trial of Isotretinoin
Authors: Lee J. Jack , Feng Lei , Reshef Daniel S. , Sabichi Anita L. , Williams Brendell , Rinsurongkawong Waree , Wistuba Ignacio I. , Lotan Reuben , Lippman Scott M.
Published: April 2023

Supplementary Figure 2B from Mortality in the Randomized, Controlled Lung Intergroup Trial of Isotretinoin
Perspective on this Article from Intratumoral Epiregulin Is a Marker of Advanced Disease in Non–Small Cell Lung Cancer Patients and Confers Invasive Properties on EGFR-Mutant Cells
Authors: Zhang Jie , Iwanaga Kentaro , Choi Kuicheon C. , Wislez Marie , Raso Maria Gabriela , Wei Wei , Wistuba Ignacio I. , Kurie Jonathan M.
Published: April 2023

Perspective on this Article from Intratumoral Epiregulin Is a Marker of Advanced Disease in Non–Small Cell Lung Cancer Patients and Confers Invasive Properties on EGFR-Mutant Cells
Supplementary Table 4 from Allelic Transcripts Dosage Effect in Morphologically Normal Ovarian Cells from Heterozygous Carriers of a BRCA1/2 French Canadian Founder Mutation
Authors: Abd-Rabbo Diala , Abaji Christine , Cardin Guillaume B. , Filali-Mouhim Abdelali , Arous Caroline , Portelance Lise , Escobar Enrique , Cloutier Sophie , Tonin Patricia N. , Provencher Diane M. , Mes-Masson Anne-Marie , Maugard Christine M.
Published: April 2023

PDF file - 106K, Supplementary Table 4a. Oligonucleotides and Probes utilized for candidate genes quantification by q-RT-PCR Supplementary Table 4b. Oligonucleotides and Probes utilized for BRCA1 and BRCA2 quantification by q-RT-PCR
Supplementary Table 2 from Allelic Transcripts Dosage Effect in Morphologically Normal Ovarian Cells from Heterozygous Carriers of a BRCA1/2 French Canadian Founder Mutation
Authors: Abd-Rabbo Diala , Abaji Christine , Cardin Guillaume B. , Filali-Mouhim Abdelali , Arous Caroline , Portelance Lise , Escobar Enrique , Cloutier Sophie , Tonin Patricia N. , Provencher Diane M. , Mes-Masson Anne-Marie , Maugard Christine M.
Published: April 2023

PDF file - 123K, Review of inherited ovarian literature
Supplementary Table 1 from Allelic Transcripts Dosage Effect in Morphologically Normal Ovarian Cells from Heterozygous Carriers of a BRCA1/2 French Canadian Founder Mutation
Authors: Abd-Rabbo Diala , Abaji Christine , Cardin Guillaume B. , Filali-Mouhim Abdelali , Arous Caroline , Portelance Lise , Escobar Enrique , Cloutier Sophie , Tonin Patricia N. , Provencher Diane M. , Mes-Masson Anne-Marie , Maugard Christine M.
Published: April 2023

PDF file - 65K, Summary of significant Limma Analysis Result for each of the candidate genes and contrast tested
Supplementary Figures 1 - 6, Tables 1 - 8 from Genes with Aberrant Expression in Murine Preneoplastic Intestine Show Epigenetic and Expression Changes in Normal Mucosa of Colon Cancer Patients
Authors: Leclerc Daniel , Lévesque Nancy , Cao Yuanhang , Deng Liyuan , Wu Qing , Powell Jasmine , Sapienza Carmen , Rozen Rima
Published: April 2023

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Supplementary Figure S1: Confirmation of the quality of RNA in microarray experiments by denaturing gel electrophoresis in 1% agarose.

Supplementary Figure S2: Representative pyrograms for PDK4, SPRR2A, SPRR1A, NR1H4 and PYCARD.

Supplementary Figure S3: Identification of individual genes and functional gene categories with significant expression changes between BALB/c Mthfr+/- FD and BALB/c Mthfr+/+ CD mice.

Supplementary Figure S4: Effect of diet and Mthfr genotype on expression of eight genes in normal intestine of BALB/c mice.

Supplementary Figure S5: Correlation of methylation results between quantitative bisulfite-pyrosequencing and the Infinium methylation array.

Supplementary Figure S6: Confirmation of DNA methylation differences in normal colon between control subjects and individuals with CRC.

Supplementary Table S1: Description of control subjects.

Supplementary Table S2: Description of cancer patients.

Supplementary Table S3: Primer pairs for qRT-PCR for the 13 genes in Figs S1 and S2, and the internal control, Gapdh.

Supplementary Table S4: Taqman primers and probes for qRT-PCR of human genes.

Supplementary Table S5: Oligonucleotides used for pyrosequencing (PCR primers and sequencing primers).

Supplementary Table S6: List of probe sets showing significant changes comparing Mthfr+/- FD and Mthfr+/+ CD BALB/c mice.

Supplementary Table S7: Relative mRNA levels for four genes related to PPAR activation (Bcmo1, Aldh1a1), oxidative stress sensitivity (Sprr2a) or oxidative response (Ugt2b36).

Supplementary Table S8: Relative expression of PPAR responsive genes.
Supplementary Table 3 from Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck Cancers
Authors: Park Il-Seok , Chang Xiaofei , Loyo Myriam , Wu Gaosong , Chuang Alice , Kim Myoung Sook , Chae Young Kwang , Lyford-Pike Sofia , Westra William H. , Saunders John R. , Sidransky David , Pai Sara Isabel
Published: April 2023

Supplementary Table 3 from Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck Cancers
Supplementary Table 3 from Ultrasensitive Detection of Unknown Colon Cancer-Initiating Mutations Using the Example of the Adenomatous Polyposis Coli Gene
Authors: Gerecke Christian , Mascher Conny , Gottschalk Uwe , Kleuser Burkhard , Scholtka Bettina
Published: April 2023

PDF - 68K, APC mutation analysis by WTB-HRM of human colon tissue compared with previous results obtained by direct sequencing. HRM results were confirmed by control sequencing of HRM products. Recovery of APC mutations was examined in available corresponding stool DNA.
Supplementary Table 1 from Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck Cancers
Authors: Park Il-Seok , Chang Xiaofei , Loyo Myriam , Wu Gaosong , Chuang Alice , Kim Myoung Sook , Chae Young Kwang , Lyford-Pike Sofia , Westra William H. , Saunders John R. , Sidransky David , Pai Sara Isabel
Published: April 2023

Supplementary Table 1 from Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck Cancers
Supplementary Figure 1 from Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck Cancers
Authors: Park Il-Seok , Chang Xiaofei , Loyo Myriam , Wu Gaosong , Chuang Alice , Kim Myoung Sook , Chae Young Kwang , Lyford-Pike Sofia , Westra William H. , Saunders John R. , Sidransky David , Pai Sara Isabel
Published: April 2023

Supplementary Figure 1 from Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck Cancers
Related Articles / Press Coverage from Chemoprevention Meets Glucose Control
Authors: Engelman Jeffrey A. , Cantley Lewis C.
Published: April 2023

Related Articles / Press Coverage from Chemoprevention Meets Glucose Control
Supplemental Table S3 from Isoflavone Pharmacokinetics and Metabolism after Consumption of a Standardized Soy and Soy–Almond Bread in Men with Asymptomatic Prostate Cancer
Authors: Ahn-Jarvis Jennifer H. , Clinton Steven K. , Grainger Elizabeth M. , Riedl Kenneth M. , Schwartz Steven J. , Lee Mei-Ling T. , Cruz-Cano Raul , Young Gregory S. , Lesinski Gregory B. , Vodovotz Yael
Published: April 2023

Supplemental Table S3. Demographic, clinical, and pathological characteristics of 25 men with biochemical recurrent prostate cancer
Supplementary Figure 1 from N-nitroso-tris-chloroethylurea Induces Premalignant Squamous Dysplasia in Mice
Authors: Hudish Tyler M. , Opincariu Laura I. , Mozer Anthony B. , Johnson Micah S. , Cleaver Timothy G. , Malkoski Stephen P. , Merrick Daniel T. , Keith Robert L.
Published: April 2023

PDF file - 152K, weight fluctuation in animals receiving 40mM NTCU. This group was divided into two waves (panels A and B), with differing periods of suspensions (arrows) throughout the study. Weight recovery is observable following treatment suspensions. Cessation of treatment is represented with an arrowhead.
Supplemental Table S2 from Isoflavone Pharmacokinetics and Metabolism after Consumption of a Standardized Soy and Soy–Almond Bread in Men with Asymptomatic Prostate Cancer
Authors: Ahn-Jarvis Jennifer H. , Clinton Steven K. , Grainger Elizabeth M. , Riedl Kenneth M. , Schwartz Steven J. , Lee Mei-Ling T. , Cruz-Cano Raul , Young Gregory S. , Lesinski Gregory B. , Vodovotz Yael
Published: April 2023

Supplemental Table S2. Nutrient and isoflavone content of the soy and soy-almond bread consumed and the meals ingested during day one of the pharmacokinetic study
Supplemental Materials and Methods (S1) from Isoflavone Pharmacokinetics and Metabolism after Consumption of a Standardized Soy and Soy–Almond Bread in Men with Asymptomatic Prostate Cancer
Authors: Ahn-Jarvis Jennifer H. , Clinton Steven K. , Grainger Elizabeth M. , Riedl Kenneth M. , Schwartz Steven J. , Lee Mei-Ling T. , Cruz-Cano Raul , Young Gregory S. , Lesinski Gregory B. , Vodovotz Yael
Published: April 2023

Supplemental Methods details the methods for preparation and standardization of study soy breads and the quantification of isoflavonoids in blood samples
Supplemental Figure S4 from Isoflavone Pharmacokinetics and Metabolism after Consumption of a Standardized Soy and Soy–Almond Bread in Men with Asymptomatic Prostate Cancer
Authors: Ahn-Jarvis Jennifer H. , Clinton Steven K. , Grainger Elizabeth M. , Riedl Kenneth M. , Schwartz Steven J. , Lee Mei-Ling T. , Cruz-Cano Raul , Young Gregory S. , Lesinski Gregory B. , Vodovotz Yael
Published: April 2023

Supplemental Figure S4. Supplemental Figure S4 Plasma isoflavone levels over a 24 hour period after a single meal with soy bread and soy-almond bread.
Supplementary Table 1 from Raloxifene and Antiestrogenic Gonadorelin Inhibits Intestinal Tumorigenesis by Modulating Immune Cells and Decreasing Stem-like Cells
Authors: Janakiram Naveena B. , Mohammed Altaf , Brewer Misty , Bryant Taylor , Biddick Laura , Lightfoot Stan , Pathuri Gopal , Gali Hariprasad , Rao Chinthalapally V.
Published: April 2023

PDF file - 61K, Primer sequences and PCR conditions for Lgr5, EpCAM, CD44, CD24, GAPDH, 5-LOX, mPGES-1, beta-catenin and cyclin D1.
Supplementary Methods, Figure 1 from Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell–Mediated Tumor Killing and Memory Responses
Authors: Nagaraja Ganachari M. , Kaur Punit , Neumann William , Asea Edwina E. , Bausero María A. , Multhoff Gabriele , Asea Alexzander
Published: April 2023

PDF file - 283K