bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between verbal form and event structure in sign languages
Authors: Davidson Kathryn , Kocab Annemarie , Sims Andrea D. , Wagner Laura
Published: November 2019

Whether predicates describe events as inherently bounded (telic) or unbounded (atelic) is usually understood to be an emergent property that depends on several factors; few, if any, spoken languages have dedicated morphology to mark the distinction. It is thus surprising that sign languages have been proposed to have dedicated morphology for telicity, and moreover that it takes a form which iconically reflects the underlying event structure – this is known as the “Event Visibility Hypothesis” (EVH) (Wilbur 2008). The EVH has been extended with claims about its universality in sign languages (Wilbur 2008; Malaia & Wilbur 2012), its gradient nature (Kuhn 2017), and its iconic transparency (Strickland et al. 2015). However, in this paper we argue that the status of this relationship between form and meaning remains an open question due to (a) lack of independent tests for telicity, (b) lack of lexical coverage, (c) lack of demonstration that formal expressions of telicity are morphological in nature, rather than a lexical property, and (d) inability to sufficiently dissociate telicity and perfectivity. We present new data coming from verbs that alternate in both form and meaning in ASL that is in line with the EVH, and conclude that while there is evidence supporting a morphological marker, the proposed form and telicity are not isomorphic in their distribution, significantly limiting the “visibility” of the event structure. We further propose that much of the related iconicity is the result of several independent factors also found in spoken languages, so that sign languages may be more similar to spoken languages than typically implied in this domain.
Comparative and Demonstrative Study Between the Liquidity of Islamic and Conventional Banks in a Financial Stability Period: Which Type of Banks Is the Most Liquid?
Authors: Haddad Achraf , El Ammari Anis , Bouri Abdelfettah
Published: November 2019

Due to the failure of several conventional banks and the closure of some Islamic banks around the world, both types are exposed to the risk of liquidation and bankruptcy. Theoretically, knowledge production has until recently been the monopoly of academic research (Vinck, 2000). The choice of the most liquid type of bank and which maximizes the liquidity of its customers is a problem to be solved. Since most of the previous studies that have dealt with relative or comparative banking liquidity are unconfirming, our research interest is to overcome these constraints in order to provide a more optimistic answer. Two samples were removed from two reference populations over the period (2010-2018). Samples were selected from 16 countries. Basic populations consist of all existing conventional and Islamic banks in the selected countries. The choice of banks is limited to countries whose banking systems incorporate both types. Subsequently, the list for each type of banks was reduced on the basis of qualitative and quantitative filtering criteria. Therefore, each conventional bank has its closest Islamic equivalence in terms of capital and size taken from the same country. This restriction reduced the sample size to 63 large banks each. All selected banks were listed in different stock exchanges around the world. Empirical results showed that Islamic banks are more liquid than conventional banks during a financial stable period.
A survey of clinical nurses’ research needs for research support from university faculty
Authors: Hiyama Akiko , Fujii Mizue , Kikuchi Hiromi , Muramatsu Masumi , Ono Natsuyo , Inomata Chiyoko , Yamamoto Katsunori
Published: November 2019

Supporting university faculty who are engaging in clinical research through continuing education can increase the effectiveness of education. This descriptive study aimed to describe the needs of nurses who are pursuing research and to clarify future activities to support their research. Data were collected using a questionnaire. Participants included 249 nurses currently working at seven different hospitals and who had conducted research supported by a university from FY2007 to FY2016. The questionnaire assessed the degree of difficulty of pursuing research and the need for support. In total, 177 nurses were included in the final analysis (valid response rate: 65.8%). The ethics review question had a median score of 3, indicating moderate difficulty. Both the methods and data analysis questions had median scores of 5 on the support need scale, indicating a high need for support, whereas the presentation question had a median score of 3 (moderate need for support). The literature review had the lowest percentage of participants who reported being satisfied with the support received, at 83.1%; however, 98.1% were satisfied with the support received for the ethics review. These results indicate that the following factors should be addressed to better support research among clinical nurses: teaching methods, reviewing the literature, selecting an appropriate research method, and analyzing the data. Our results also demonstrated that nurses were relatively dissatisfied with the methods of communication used in research. Nurses reported that future support should emphasize improving methods of support and effectively clarifying the needs of human resource development.
Handwashing Practices Among Children in Public Schools in Imo State, Nigeria
Authors: Nwajiuba Chinyere Augusta , Ogunji Chinwe Victoria , Uwakwe Rowland Chukwuemeka , David Esther Ihuoma
Published: November 2019

This study examined the availability and utilization of handwashing facilities among public primary school pupils in Okigwe Education Zone two (2) of Imo State, Nigeria. Four research questions were posed to guide the study. One hypothesis was formulated and tested. The study adopted a survey research design. Random sampling technique was used to select a sample size for the study. 295 pupils (age bracket 6–14 years) from 12 public primary schools and their form teachers participated in the study. Data were collected with the aid of a structured questionnaire designed from UNICEF's checklist modules for appraising hand washing facilities in schools. Also, observation and focus group discussion were used for the data collection on handwashing practices among pupils using hand washing facilities.Data generated were analyzed using percentage and frequency distribution counts in order to answer the research questions. All information from the focus group discussion using codes and themes were transcribed, grouped and analyzed based on the specific objectives. Findings suggest that out of the twelve schools observed, only two schools had both a handwashing basin with clean water that runs and improvised handwashing facilities at the same time. Based on the findings, hand washing facilities and supplies should be a major priority in all primary schools in Okigwe Education Zone 2 because of its importance in preventing communicable diseases. School health educators should work in conjunction with the Parents Teachers Association of each school to ensure constant and adequate provision of handwashing facilities and supplies. This will further encourage their usage and also reduce absence from schools due to infections.
Estimation of the Predictive Powers of Teachers’ Pedagogical Skills on Pupils’ Academic Achievement in Christian Religious Studies in South-East, Nigeria
Authors: Ezema Victor Sunday , Ejiofor Juliana N. , Orji Joy Chioma , Okenyi Emmanuel Chidobe , Achagh Wilfred Iorfa , Ibiam Julie U. , Ugwuanyi Christian Sunday , Illechukwu Leonard C. , Nnadi Ekwutosi Monica
Published: November 2019

The general purpose of this study was to determine teachers’ pedagogical skills as predictors of pupils’ academic achievement in Christian Religious Studies in South East, Nigeria. The study adopted a correlation research design. Two questions were posed and two hypotheses were formulated and tested for the study. The study was carried out in all the primary schools in South-East, Nigeria. The population of the study included all the 42,796 primary school teachers in South-East, Nigeria. A sample of 855 public primary school teachers was drawn for the study using a multi-stage random sampling procedure. Two instruments were used for data collection, they are: Teachers’ Pedagogical Skills Questionnaire (TPSQ) and Pupils’ Academic Achievement Proforma (PAAP). The instruments were validated by three experts. The reliability of the instrument was established by trial-testing on 20 primary school teachers that were randomly drawn from Ezinihite-Mbaise Local Government Area of Imo State which is a part of the study area but not a sampled area. Cronbach’s Alpha Reliability Coefficient was used to determine the internal consistency reliability index 0.89 for TPSQ. Data collected were analyzed using Correlation Coefficient and Regression Analysis of Variance was used to test the hypotheses at 0.05 level of significance. The findings revealed that teachers’ pedagogical skills significantly predicted pupils’ academic achievement in Christian Religious Studies in South-East. It was recommended that teachers should possess sufficient knowledge and skills regarding curriculum content and classroom management in order to overcome classroom challenges.
How Can Be Academic Talent Measured During Higher Education Studies? - An Exploratory Study
Authors: Szabó János
Published: November 2019

Many articles claim that talent management is a very important aspect of higher education. Despite of this, the studies, which investigate this topic empirically, are very rare. The Hungarian higher education talent management focuses mainly on academic-, scientific aspect of talent. So, the main purpose of talent-management is the academic reinforcement, namely, growing up a new generation of scientist/university teachers. The talent management in higher education can be imagined as a bridge between formal school studies and scientific career. In this study, I search answer for the (research) question: how should academic talent be measured during higher education studies? Moreover, does it have any sense to identify the academic talents during even their higher education studies? The research is based on opinion of 170 university teachers who supervised talented students during a young-researcher competition. The method was questionnaire-method. The questions gathered round two main topics: (1) identifying of talented students and cooperation with talented students; (2) own career of supervisor university teachers. The results had been analyzed with descriptive statistics which show the mostly chosen talent-identifying methods and features of talented students. The open-ended questions had been content-analyzed. The data of university-teacher’s career had been analyzed with mathematical statistical tests (ANOVAs, Two-sample T tests, correlations) where the dependent variable was the number of publication (as indicator of the scientific performance). The results may suggest conceptions for talent-programs (honor programs) based on academic talent; for doctoral schools, and for any other institutes who works with career entrant scientist. The scientific reinforcement would be more effective if scientific programs/scholarships/PhD-programs used professional methods during selection process, instead of subjective choices, based on CV and motivation letter.
Perspectives on World and Regional Orders: Australian, Chinese and German Views
Authors: Schneider Patricia , Sun Fanglu , Wood Steve
Published: November 2019

This article offers some reflections from diverse standpoints on actual and potential developments, at global and regional levels, and possible ramifications. The article has three main sections. The first section deals with the crisis of liberalism and its implications for peace and security. The second section examines some current controversial issues and cooperation between the EU, Australia and China. The third section analyses the effects of populist movements in Europe on China and Australia.
Gelebte Organisations-Demokratie
Authors: Offermann Claus
Published: November 2019

Organisationen sind für Machtmissbrauch anfällig. Das Qualitätsmanagement kann dazu beitragen, bessere Verhältnisse in personenbezogenen Dienstleistungen durchzusetzen und beizubehalten.
Barrieren abbauen
Authors: Khanide Marina
Published: November 2019

Demokratische Alltagserfahrungen können durch Freiwilligendienste ermöglicht werden. Notwendig sind dazu Prozesse der interkulturellen Öffnung von Organisationen, Diensten und Einrichtungen.
Vielfalt organisieren
Authors: Neubert Lea-Friederike , Hub Rainer
Published: November 2019

Interkulturelle Öffnung als ethische Forderung braucht konkrete Prozesse der Organisationsentwicklung, wie am Beispiel ehrenamtlichen Engagements gezeigt werden kann.
Alter braucht mehr als Pflege
Authors: Leinenbach Michael
Published: November 2019

Der Deutsche Berufsverband für Soziale Arbeit hat eine Erklärung zur »Sozialen Arbeit für und mit alten Menschen« erarbeitet, um die Zielgruppe stärker in den Fokus zu rücken und Politik, Behörden, Verwaltung sowie die Träger für dieses Handlungsfeld zu sensibilisieren.
Was das Top-Management verdient
Authors: Moos Gabriele , Müller Thomas
Published: November 2019

Im Wettbewerb um qualifizierte Führungskräfte in der Sozialwirtschaft kann eine angemessene und branchenübliche Vergütung entscheidend sein. Auch darf die Differenz zu anderen Branchen nicht zu groß werden. Welche Vergütung wettbewerbsfähig ist und welche Höhe auch für gemeinnützige Organisationen angemessen erscheint, haben Prof. Dr. Gabriele Moos und Dr. Thomas Müller in einer neuen Studie ermittelt.
Rechtssichere Prozesse installieren
Authors: Kaulbars Jim , Althammer Thomas
Published: November 2019

Datenschutz ist insbesondere bei sozialen Diensten und Einrichtungen von erheblicher Bedeutung. Dazu muss auch der korrekte Umgang mit Datenpannen zählen.
Wirksamkeit ist nicht genug
Authors: Frieß Frank
Published: November 2019

Im Fundraising dominieren seit einiger Zeit die Hinweise auf die Wirksamkeit der beworbenen Organisation und ihrer Hilfen. Übersehen wird dabei oft, dass Spender vor allem »Sinn« und »Resonanz« erfahren wollen.
Mit Influencern neue Bewerber erreichen
Authors: Schäfer Maja Roedenbeck
Published: November 2019

Die Diakonie Deutschland hat in diesem Jahr eine Blogger-Kampagne für das Personalmarketing durchgeführt. Die Projektleiterin Maja Roedenbeck Schäfer erläutert die Beweggründe, den Ablauf, die Kosten - und was der Verband daraus für die Zukunft gelernt hat.
Führung entscheidet
Authors: Brandl Paul
Published: November 2019

Eine Vielzahl von Büchern zum »agilen Unternehmen« deutet darauf hin, dass man dieses Thema als Führungskraft nicht mehr umgehen kann. Ein neuer Sammelband bietet einen anregenden Einstieg.
Compreensão da mãe a respeito do cuidar de crianças estomizadas
Authors: Silva Juliana Matos , Melo Manuela Costa , Kamada Ivone
Published: November 2019

Objetivo: comprender la atención de los profesionales de la salud en el cuidado del niño ostomizado. Métodos: estudio exploratorio descriptivo con un diseño de investigación interpretativa cualitativa realizado en un hospital público de Brasilia entre diciembre de 2015 y febrero de 2016. Población compuesta por nueve madres de niños ostomizados. Se utilizaron datos del diario de campo y del guión de la entrevista semiestructurada; el análisis de las narraciones se realizó mediante el análisis de contenido, modalidad temática. Resultados: en las declaraciones maternas prevalecieron los relatos sobre la dificultad en el manejo de la ostomía, debido a la dificultad para comprender las pautas proporcionadas por los profesionales de la salud, siendo unánimes al afirmar que aprendieron más con la práctica de otras madres que de los profesionales. También insistieron en la falta de preparación de los profesionales para tratar de estos niños. Consideraciones finales e implicaciones para la práctica de enfermería: al comprender la atención brindada, se ha podido concluir que es necesario establecer prioridades para mejorar dicha atención. La evidencia encontrada puede fortalecer la atención brindada por los profesionales de la salud que trabajan con familias y niños con ostomías, no solo en la atención de rutina, sino también en acciones educativas que los capacite para enfrentar la situación
Acurácia das características definidoras da confusão aguda em usuários de um centro de atenção psicossocial
Authors: Oliveira Andriely de Souza , Silva Alexciane Priscila , Sousa Girliani Silva de , Mangueira Suzana de Oliveira , Guimarães Fernanda Jorge , Perrelli Jaqueline Galdino Albuquerque
Published: November 2019

Objetivo: analizar la precisión de un conjunto de características definitorias del diagnóstico de enfermería de confusión aguda en usuarios atendidos en un centro de atención psicosocial (CAPS). Método: estudio de precisión diagnóstica realizado en un CAPS II con 37 usuarios. Para la recogida de datos se utilizó el guión de caracterización sociodemográfica, índice de calidad del sueño de Pittsburgo (PSQI) y Confusion Assessment Method (CAM). El análisis se realizó mediante estadística descriptiva, pruebas de asociación estadística y medidas de sensibilidad y especificidad de las características definitorias, cuyo punto de corte fue del 80,0%. Resultados: los participantes tenían, en promedio, 40,16 años de edad (± 11,46) y 7,21 años de estudio (± 3,82). La mayoría eran varones, protestantes, solteros, con ingresos familiares de hasta un salario mínimo. El diagnóstico de enfermería de confusión aguda estuvo presente en el 45,9% de los participantes. La característica definitoria más sensible para la confusión aguda fue la alteración de la función cognitiva. las Las características con alta especificidad fueron las alucinaciones, percepciones erróneas, alteraciones en la función cognitiva y alteraciones en el nivel de conciencia. La alteración de la función cognitiva fue el único indicador que presentó alta sensibilidad y especificidad. Conclusión: la alteración en la función cognitiva demostró ser el indicador clínico más preciso para la inferencia del diagnóstico de enfermería de confusión aguda en usuarios atendidos en CAPS.
Atendimento em saúde mental na atenção primária à saúde no período pré-reforma psiquiátrica
Authors: Cordeiro Gisele Fernandes Tarma , Ferreira Rosa Gomes dos Santos , Almeida Antonio Jose de , Santos Tânia Cristina Franco , Figueiredo Mariângela Aparecida Gonçalves , Peres Maria Angélica de Almeida
Published: November 2019

Introducción: analizar la atención en salud mental en la atención primaria en un municipio de Minas Gerais, en la década de 1980. Método: estudio cualitativo, desde la perspectiva de la historia de la actualidad. Fuentes: documentos escritos y orales obtenidos por entrevista con seis profesionales de una unidad básica de salud (UBS). Se utilizó el método inductivo que parte de la postura crítica interna y externa de las fuentes, estableciendo las relaciones con el contexto histórico-social en el que se insertaron. Resultados: los datos dieron como resultado dos categorías: revelando la realidad del manicomio en Juiz de Fora a través de la narrativa de los profesionales de la unidad básica de salud y los informes de los profesionales sobre las dificultades para comprender la propuesta de reforma y las consecuencias en la organización de los servicios y en la atención. Discusión: en el período previo a la reforma psiquiátrica, el proceso de deshospitalización determinó una demanda de atención de salud mental en la UBS que, debido a la falta de preparación del personal de salud, no fue recibida adecuadamente. La atención de las UBS seguía la lógica del manicomio y no contempló suficientemente los cuidados de las personas con trastornos mentales, limitándose a la reproducción de recetas médicas y derivaciones a los servicios especializados. Conclusión: el equipo enfrentó, en la medida de lo posible, las dificultades encontradas y la UBS estudiada fue pionera en la atención de salud mental extrahospitalaria, después calificado por la Secretaría Municipal de Salud Mental de Juiz de Fora.
Satisfação de pacientes com o cuidado de enfermagem em unidades cirúrgicas
Authors: Santos José Luís Guedes dos , De-Pin Shara Bianca , Menegon Fernando Henrique , Sebold Luciara , Nascimento Keyla Cristiane do , Gelbcke Francine Lima
Published: November 2019

Objetivo: analizar la satisfacción de pacientes con la atención de enfermería en las unidades quirúrgicas. Método: investigación de método mixto, con estrategia explicativa secuencial, realizada en un hospital universitario del sur de Brasil. Se recogieron datos cuantitativos de 200 pacientes de unidades quirúrgicas a través de su ficha de caracterización y del instrumento de satisfacción. Tales datos cuantitativos se sometieron a un análisis estadístico descriptivo e inferencial. Los datos cualitativos se recogieron a través de entrevistas telefónicas con 20 pacientes y se procesaron mediante el análisis de contenido. Resultados: el promedio de satisfacción general entre los usuarios fue de 3,95 (± 0,54). Entre los dominios del instrumento, los promedios fueron: técnico-profesional (4,10 ± 0,59), confianza (3,96 ± 0,56) y educativo (3,80 ± 0,63). En las entrevistas, los pacientes realzaron la alegría, el entusiasmo y el celo del personal de enfermería al realizar sus tareas. Conclusión: ha quedadoes evidente que los pacientes están satisfechos con la atención de enfermería, especialmente con la competencia técnica de su personal.
Validação do instrumento de avaliação do conhecimento dos agentes comunitários de saúde sobre diabetes
Authors: Cordeiro Eduardo Maciel , Miranda Tatiana Teixeira de , Rabelo Suzana Nunes , Pagano Adriana Silvina , Reis Ilka Afonso , Torres Heloisa de Carvalho , Reis Janice Sepúlveda
Published: November 2019

Objetivo: elaborar, adaptar culturalmente y validar el "conocimiento de los agentes de salud comunitarios (ACS) sobre la diabetes" – diabetes-ACS – para evaluar el conocimiento de los ACS sobre la diabetes mellitus. Métodos: Estudio metodológico desarrollado en tres etapas: a) construcción del instrumento; b) validación de contenido y adecuación cultural con médicos de familia y ACS, seguido de evaluación de sugerencias por parte de un comité de expertos; c) validación psicométrica del instrumento a partir de la aplicación en una muestra de 102 ACS, a través de la herramienta e-Surv. Los análisis de consistencia interna y reproducibilidad se realizaron en el entorno de programación estadística R. Resultados: el instrumento, que consta de 29 preguntas de opción múltiple, tuvo consistencia interna satisfactoria, con alfa de Cronbach 0,732 (IC 95% 0,652; 0,802) y coeficiente de correlación intraclase de 0,70 (IC del 95%: 0,59 a 0,79) entre los puntajes de prueba y retest. Conclusión: el instrumento diabetes-ACS se considera apropiado y validado para la evaluación de agentes comunitarios de salud.
Prevalência do estresse e síndrome de burnout em enfermeiros no trabalho hospitalar em turnos
Authors: Bezerra Clarissa Maria Bandeira , Silva Kézia Katiane Medeiros da , Costa Jéssika Wanessa Soares da , Farias Joberto de Carvalho , Martino Milva Maria Figueiredo de , Medeiros Soraya Maria de
Published: November 2019

Introducción: el servicio de enfermería a menudo está relacionado con malas condiciones, un entorno poco saludable, horas de trabajo excesivas, exposición a riesgos, relacionado con la susceptibilidad y las condiciones de salud del trabajador. Estos factores pueden conducir a trastornos psicológicos como el estrés y el síndrome de burnout. Objetivo: verificar el nivel de estrés y la existencia del síndrome de burnout en enfermeros en turnos de trabajo hospitalario. Método: estudio de enfoque descriptivo y analítico, realizado en un hospital universitario. La muestra estuvo compuesta por 108 enfermeros. Para la recolegida de datos se utilizaron cuestionarios, uno de los cuales verificó datos sociodemográficos, la Escala de Bianchi modificada, para cuantificar el nivel de estrés; y el Inventario de Burnout de Maslach – Encuesta de Servicios Humanos, para identificar el burnout. Resultados: los datos mostraron que las dimensiones de agotamiento para los grupos diurnos y nocturnos se consideraron de medio para bajo. Se encontraron correlaciones y valores de p estadísticamente significativos cuando se compararon el estrés y las dimensiones de p = <0.0001; p = 0,0001; y p = 0,0003. El puntaje para el nivel de estrés del turno diurno fue de 2,35 y del nocturno de 2,31, que se clasificaron como medios. Conclusión: el nivel de estrés entre los enfermeros y las tres dimensiones del síndrome se evaluaron como nivel medio durante los turnos diurnos y nocturnos. Hubo una correlación estadísticamente significativa entre el estrés y el agotamiento.
Digestiflow: from BCL to FASTQ with ease
Authors: Holtgrewe Manuel , Nieminen Mikko , Messerschmidt Clemens , Beule Dieter
Published: November 2019

Management raw sequencing data and its preprocessing (conversion into sequences and demultiplexing) remains a challenging topic for groups running sequencing devices. They face many challenges in such efforts and solutions ranging from manual management of spreadsheets to very complex and customized LIMS systems handling much more than just sequencing raw data. In this manuscript, we describe the software package DigestiFlow that focuses on the management of Illumina flow cell sample sheets and raw data. It allows for automated extraction of information from flow cell data and management of sample sheets. Furthermore, it allows for the automated and reproducible conversion of Illumina base calls to sequences and the demultiplexing thereof using bcl2fastq and Picard Tools, followed by quality control report generation.
An essay on individual self-determination
Authors: Afonso Margarete , Barros Ernane Pedro Matos , Cavalcanti Matheus Paiva Emidio , Ribeiro Mariane Albuquerque Lima
Published: November 2019

There are several understandings about the role of human gender identity in the scientific field, this discussion correlates definitions of both social and biological basis. The current confusion in the conceptualization of “sex” and “gender” demonstrates the need for a comparative analysis of the scientific dynamic vocabulary, as well as the insertion of an interdisciplinary historical, social and cultural point of view together with the biological view outside the normative binary logic. The word “gender” can be defined as the social construction of sex, differing from the variable “sex” because it refers to a biological dimension of the anatomo-physiological characterization of humans, recognized as essential and innate in determining the distinctions between male and female. Therefore, the JHGD presents a thematic diversity that focuses on issues related to public health, demonstrating the need to develop knowledge to generate impact on public policy strategies, aiming at universality, equity and comprehensiveness in scientific research involving sexand gender and their impacts on health sciences.
Impacto da idade materna na acidez do colostro de nutrizes em maternidade do interior do Estado de São Paulo
Authors: Moraes Lucas Lima de , Campos Letícia de Aguiar , Ferrari Denise Vasconcelos de Jesus , Saeki Erika Kushikawa , Polettini Jossimara , Morceli Glilciane
Published: November 2019

Objective: To analyze sociodemographic and gestational characteristics and to compare colostrum acidity content in adolescent and advanced maternal age mothers. Methods: This cross-sectional study included 98 adolescents (up to 18 year-old) and 33 advanced maternal age (more than 35 year-old) mothers admitted at the maternity of Presidente Prudente Regional Hospital, Brazil. An approximated volume of 10 mL of colostrum was obtained by manual expression of the breasts within 72h postpartum and stored at -20oC up to processing. Acidity of colostrum was evaluated in Dornic degrees. Statistical analysis was performed using Mann-Whitney test or X2. Results: The median age adolescents and advanced maternal age mothers were 20 years (12-24) 37 years (35-45), respectively. The majority of the adolescents (66.3%) were primiparous and C-section delivery had occurred in 66.7% of advanced age mothers. Gestational body mass index (BMI) was statically higher in advanced maternal age women (32.17±5.6 vs 26.09±3.6, p< 0.0001). Acidity measurement was similar between the studied groups. Conclusions: Sociodemographic and gestational characteristics of adolescents and advanced age mothers showed population heterogeneity, thus, specific follow up and orientations should be applied at each one. Colostrum constitution was constant regarding casein and proteins content, independently of maternal age.
Efeitos de 12 semanas de intervenções interdisciplinares em parâmetros comportamentais e alimentares de adolescentes com excesso de peso ou obesidade
Authors: Costa Lorany , Rubio Ketlin Laise , Lopes Solange Munhoz Arroyo , Tanouye Andressa Tiemi de Andrade , Bertolini Sônia Maria Marques Gomes , Branco Braulio Henrique Magnani
Published: November 2019

Objetctive: To analyze the 12 weeks’ effects of interdisciplinary interventions on behavioral and eating  parameters of overweight or obese adolescents. Methods: This study presents a longitudinal and quasiexperimental design. 40 adolescents aged 16 ± 1 years were selected to participate on the study. Therefore, only 17 completed the 12 weeks of interdisciplinary interventions. The interventions were realized by physical education professionals (physical exercises three times a week), physiotherapists (exercises to strengthen the core and postural exercises three times a week), nutrition (feeding re-education twice a week) and cognitive-behavioral therapy (focus on behavior change and adoption of an active lifestyle once a week). In order to quantify the adolescents’ behavioral parameters, the questionnaires were: Body Shape Questionnaire (BSQ), Eating Attitudes Test (EAT), Rosenberg self-esteem scale (RAS) and Hamilton anxiety scale (HAS). Results: For BSQ’s answer 9: “are you with thin people of the same sex as you, make you feel worried about your physique? “A significant reduction in the responses attributed by the adolescents at the post-intervention (p<0.05) level was identified, as well as for the HAS, in question 3: fear - of the dark, of unknown, of the crowd, of being abandoned, large animals, transit”, with lower values (p<0.05) after interdisciplinary interventions. Conclusion: Interdisciplinary interventions resulted in improvements in body image in relation to the perception of physical state, as well as in a decrease in fear presented by adolescents. The 12 weeks of interventions presented slight changes in the adolescents’ behavior analyzed in the study.
Complete Androgen Insensitivity Syndrome and Literature Review
Authors: Calderon Mauricio Giusti , Lemos Carolina Maria Barbosa , Alem Mariana Drigo , Pinelli Thais Cristina , Raimundo Rodrigo Daminello
Published: November 2019

Backgroung: Complete Androgen Insensitivity Syndrome (CAIS) has been reported since 1923, but in 1953 it became known as “testicular feminization”. It is a rare recessive genetic disorder linked to the X chromosome that results in different mutations in the androgen receptor. The main clinical presentation in childhood is the presence of bilateral inguinal hernia in phenotypically female subjects. Incidence of androgen  insensitivity syndrome in phenotypically females with inguinal hernia is estimated in 0.8% to 2.4%. This is a case report of complete androgen insensitivity syndrome and literature review of preoperative diagnostic methods. Case Summary: We present a 3 years and 6 months old child with female phenotype, born in São Paulo, Brazil which was diagnosed intraoperatively with complete androgen insensitivity syndrome, during inguinal hernia repair and present potential diagnostic alternatives that we consider viable options in order to avoid this kind of surprise during surgery. Conclusion: Investigation of CAIS should be standard in prepubertal girls with bilateral inguinal hernia, genetic techniques involving X chromatin or Y chromosome tests present the best choices.
Adaptação cultural em Português Brasileiro da Derriford Appearance Scale – 24 (DAS-24) para pessoas vivendo com HIV/AIDS
Authors: Martins Marcos Alberto , Neves Angela Nogueira , Moss Timothy , Martins Walter Henrique , Pereira Gerson Vilhena , Pessôa Karina Viviani de Oliveira , Silva Mariliza Henrique da , Abreu Luiz Carlos de
Published: November 2019

Introduction: Body image can be defined as the representation of beliefs, emotions and perceptions about the body itself, manifested in behaviors directed to the body. When the body changes because of a disease and does not seem healthy, the self-concept may be severely challenged. People living with HIV/AIDS (PLHA) are particularly vulnerable to the distress and psychosocial impact of appearance, but in Brazil the assessment of those body image changes was subjective because there was not an available scale in Brazilian Portuguese to assess body image changes in clinical practice or research. Objective: To carry out the cross-cultural adaptation to the Brazilian Portuguese of the Derriford Appearance Scale 24 (DAS-24), with the verification of the linguistic, semantic, conceptual and cultural equivalence of the people living with HIV/AIDS in Brazil. Methods: We followed the five stages of culturally sensitive translation: direct translations, synthesis of translations, back-translations, expert committee meeting and pre-tests. The process of cultural adaptation was presented in a descriptive and analytical way, following patterns of methodological studies. The minimum, maximum and median values of the responses of each item were calculated from the pool of data from the third pretest group of 50 participants. The median of the item scores, the correlation on each item with the total score and the internal reliability, were calculated using the Cronbach alpha test. Results: The analysis of the responses of the last pre-test group indicated that attention must be given to itemsA, H, T and V in a future psychometric study. The present study is not enough for this scale to be used in clinical practice. To ensure that the culturally adapted instrument generates valid and reliable data, a subsequent study investigating its psychometric properties should be conducted. Conclusion: The cross-cultural adaptation of the Derriford Appearance Scale 24 (DAS-24) in its components of linguistic, semantic, conceptual and cultural equivalence to Brazilian Portuguese for the population of people living with HIV/AIDS was fully carried out. Despite this achievement, it is emphasized that the use of the Brazilian versionof DAS-24 in research and clinical routine is advised only after a psychometric study with this instrument.
Prevalência e fatores associados à obesidade em crianças menores que cinco anos no município de Rio Branco – Acre
Authors: Silva Delcio Damasceno da , Lima Marcos Venicius Malveira de , Muniz Pascoal Torres , Holanda Marlon Negreiros de , Câmara Ozianndeny Ferreira , Monteiro Adilson , Wajnsztejn Rubens
Published: November 2019

Introduction: The nutritional status of children is considered an important instrument in measuring the health conditions and quality of life of a population. The increasing prevalence of obesity in children is a significant public health problem as it is an important risk factor for obesity in adulthood. Objective: To evaluate the prevalence and factors associated with childhood obesity in the city of Rio Branco - Acre.  Method: A database analysis was carried out from the Risk Factors and Morbidity Survey for Noncommunicable Diseases in the Municipality of Rio Branco / Health and Nutrition for Adults and Children in 2008.This cross-sectional study examined 687 children aged 0 to 60 months in urban and rural areas. Statistical analysis considered expansion and sample design. The prevalence of childhood obesity according to the anthropometric indices P / I (weight for age), P / E (weight for height) and BMI / I (Body Mass Index) were respectively 6.85% (95% CI = 5.30). - 8.80), 6.66% (95% CI = 3.22 - 13.27) and 6.61% (95% CI = 3.25 - 12.98). Results: The final model showed a higher prevalence of obesity in the BMI / I index under the following conditions: home in the urban area (PR = 6.81; 95% CI = 1.27 - 36.38), electric lighting without meter (PR = 2.10; 95% CI = 1.22 - 3.59), mother’s height greater than 163cm (PR = 2.24; 95% CI = 1.12 - 4.47) and maternal obesity (RP = 2.37 95% CI = 1.19 - 4.72). Conclusion: The prevalence of obesity in the BMI / I index was high and is related to socioeconomic factors and specific maternal characteristics. It is necessary to promote actions that lead to the formation of a healthy lifestyle even in childhood.
Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes
Authors: Selvaraj Sridhar , Mondragon-Gonzalez Ricardo , Xu Bin , Magli Alessandro , Kim Hyunkee , Lainé Jeanne , Kiley James , Mckee Holly , Rinaldi Fabrizio , Aho Joy , Tabti Nacira , Shen Wei , Perlingeiro Rita CR
Published: November 2019

Targeted differentiation of pluripotent stem (PS) cells into myotubes enables in vitro disease modeling of skeletal muscle diseases. Although various protocols achieve myogenic differentiation in vitro, resulting myotubes typically display an embryonic identity. This is a major hurdle for accurately recapitulating disease phenotypes in vitro, as disease commonly manifests at later stages of development. To address this problem, we identified four factors from a small molecule screen whose combinatorial treatment resulted in myotubes with enhanced maturation, as shown by the expression profile of myosin heavy chain isoforms, as well as the upregulation of genes related with muscle contractile function. These molecular changes were confirmed by global chromatin accessibility and transcriptome studies. Importantly, we also observed this maturation in three-dimensional muscle constructs, which displayed improved in vitro contractile force generation in response to electrical stimulus. Thus, we established a model for in vitro muscle maturation from PS cells.
Initiation of chromosome replication controls both division and replication cycles in E. coli through a double-adder mechanism
Authors: Witz Guillaume , van Nimwegen Erik , Julou Thomas
Published: November 2019

Living cells proliferate by completing and coordinating two cycles, a division cycle controlling cell size and a DNA replication cycle controlling the number of chromosomal copies. It remains unclear how bacteria such as Escherichia coli tightly coordinate those two cycles across a wide range of growth conditions. Here, we used time-lapse microscopy in combination with microfluidics to measure growth, division and replication in single E. coli cells in both slow and fast growth conditions. To compare different phenomenological cell cycle models, we introduce a statistical framework assessing their ability to capture the correlation structure observed in the data. In combination with stochastic simulations, our data indicate that the cell cycle is driven from one initiation event to the next rather than from birth to division and is controlled by two adder mechanisms: the added volume since the last initiation event determines the timing of both the next division and replication initiation events.
Lymphatic vessels help mend broken hearts
Authors: Pfefferli Catherine , Jaźwińska Anna
Published: November 2019

Experiments on zebrafish show that the regeneration of the heart after an injury is supported by lymphatic vessels.
Norges Naturlige Historie (1752)
Authors: Pontoppidan Erich
Published: November 2019

The file is a facsimile of extracts from the original, Danish edition of Pontoppidan's Norges Naturlige Historie (1752), covering the description of the aurora borealis in this work. For a detailed summary of contents, see the introduction by Per Pippin Aspaas, pp. 5-9.
Formation of adenovirus DNA replication compartments
Authors: Hidalgo Paloma , Gonzalez Ramón A.
Published: November 2019

Adenoviruses induce an extensive reorganization of the host cell nucleus during replication. Such a process results in the assembly of viral and cellular macromolecules into nuclear structures called adenovirus replication compartments (AdRCs), which function as platforms for viral DNA replication and gene expression. AdRCs co‐opt host proteins and cellular pathways that restrict viral replication, suggesting that the mechanisms that control AdRC formation and function are essential for viral replication and lay at the basis of virus–host interactions. Here, we review the hallmarks of AdRCs and recent progress in our understanding of the formation, composition, and function of AdRCs. Furthermore, we discuss how AdRCs facilitate the interplay between viral and cellular machineries and hijack cellular functions to promote viral genome replication and expression.
The Nbp35/ApbC homolog acts as a nonessential [4Fe‐4S] transfer protein in methanogenic archaea
Authors: Zhao Cuiping , Lyu Zhe , Long Feng , Akinyemi Taiwo , Manakongtreecheep Kasidet , Söll Dieter , Whitman William B. , Vinyard David J. , Liu Yuchen
Published: November 2019

The nucleotide binding protein 35 (Nbp35)/cytosolic Fe‐S cluster deficient 1 (Cfd1)/alternative pyrimidine biosynthetic protein C (ApbC) protein homologs have been identified in all three domains of life. In eukaryotes, the Nbp35/Cfd1 heterocomplex is an essential Fe‐S cluster assembly scaffold required for the maturation of Fe‐S proteins in the cytosol and nucleus, whereas the bacterial ApbC is an Fe‐S cluster transfer protein only involved in the maturation of a specific target protein. Here, we show that the Nbp35/ApbC homolog MMP0704 purified from its native archaeal host Methanococcus maripaludis contains a [4Fe‐4S] cluster that can be transferred to a [4Fe‐4S] apoprotein. Deletion of mmp0704 from M. maripaludis does not cause growth deficiency under our tested conditions. Our data indicate that Nbp35/ApbC is a nonessential [4Fe‐4S] cluster transfer protein in methanogenic archaea.
SCN1B‐linked early infantile developmental and epileptic encephalopathy
Authors: Aeby Alec , Sculier Claudine , Bouza Alexandra A. , Askar Brandon , Lederer Damien , Schoonjans Anne‐Sofie , Vander Ghinst Marc , Ceulemans Berten , Offord James , Lopez‐Santiago Luis F. , Isom Lori L.
Published: November 2019

Objective

Patients with Early Infantile Epileptic Encephalopathy (EIEE) 52 have inherited, homozygous variants in the gene SCN1B, encoding the voltage‐gated sodium channel (VGSC) β1 and β1B non‐pore‐forming subunits.

Methods

Here, we describe the detailed electroclinical features of a biallelic SCN1B patient with a previously unreported variant, p.Arg85Cys.

Results

The female proband showed hypotonia from birth, multifocal myoclonus at 2.5 months, then focal seizures and myoclonic status epilepticus (SE) at 3 months, triggered by fever. Auditory brainstem response (ABR) showed bilateral hearing loss. Epilepsy was refractory and the patient had virtually no development. Administration of fenfluramine resulted in a significant reduction in seizure frequency and resolution of SE episodes that persisted after a 2‐year follow‐up. The patient phenotype is more compatible with early infantile developmental and epileptic encephalopathy (DEE) than with typical Dravet syndrome (DS), as previously diagnosed for other patients with homozygous SCN1B variants. Biochemical and electrophysiological analyses of the SCN1B variant expressed in heterologous cells showed cell surface expression of the mutant β1 subunit, similar to wild‐type (WT), but with loss of normal β1‐mediated modification of human Nav1.1‐generated sodium current, suggesting that SCN1B‐p.Arg85Cys is a loss‐of‐function (LOF) variant.

Interpretation

Importantly, a review of the literature in light of our results suggests that the term, early infantile developmental and epileptic encephalopathy, is more appropriate than either EIEE or DS to describe biallelic SCN1B patients.
2019 Update of the American College of Rheumatology Recommended Rheumatoid Arthritis Disease Activity Measures
Authors: England Bryant R. , Tiong Benedict K. , Bergman Martin J. , Curtis Jeffrey R. , Kazi Salahuddin , Mikuls Ted R. , O'Dell James R. , Ranganath Veena K. , Limanni Alex , Suter Lisa G. , Michaud Kaleb
Published: November 2019

Objective

To provide updated American College of Rheumatology (ACR) recommendations on rheumatoid arthritis (RA) disease activity measurements to facilitate a treat‐to‐target approach in routine clinical care.

Methods

A working group conducted a systematic literature review from the time of the prior ACR recommendations literature search. Properties of disease activity measures were abstracted, and study quality was assessed using the Consensus‐Based Standards for the selection of Health Measurement Instruments 4‐point scoring method, allowing for overall level of evidence assessment. Measures that fulfilled a minimum standard were identified, and through a modified Delphi process preferred measures were selected for regular use in most clinic settings.

Results

The search identified 5,199 articles, of which 110 were included in the review. This search identified 46 RA disease activity measures that contained patient, provider, laboratory, and/or imaging data. Descriptions of the measures, properties, study quality, level of evidence, and feasibility were abstracted and scored. Following a modified Delphi process, 11 measures fulfilled a minimum standard for regular use in most clinic settings, and 5 measures were recommended: the Disease Activity Score in 28 Joints with Erythrocyte Sedimentation Rate or C‐Reactive Protein Level, Clinical Disease Activity Index, Simplified Disease Activity Index, Routine Assessment of Patient Index Data 3, and Patient Activity Scale‐II.

Conclusion

We have updated prior ACR recommendations for preferred RA disease activity measures, identifying 11 measures that met a minimum standard for regular use and 5 measures that were preferred for regular use in most clinic settings.