bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment of a human nasal epithelium model of histamine-induced inflammation to assess the activity of fexofenadine as an inverse agonist and its link to clinical benefit
Authors: Barbot Anne , Lheritier-Barrand Michele , Murrieta-Aguttes Margarita , Leonetti Maud , Vernaz Jimmy , Huang Song , Constant Samuel , Boda Bernadett
Published: June 2024

Background

Fexofenadine (FEX) is an antihistamine that acts as an inverse agonist against histamine (HIS) receptor 1 (H1R), which mediates the allergic reaction. Inverse agonists may be more potent than neutral antagonists, as they bind the same receptor as the agonist (HIS) but stabilize the inactive form and induce an opposite pharmacological response, suppressing the basal activity of H1R and preventing HIS from binding. This study aims to establish and validate a model of HIS-induced inflammation based on fully reconstituted human nasal epithelial tissue to assess the activity of FEX as an inverse agonist in this model and explore its link to clinical benefit.

Methods

The model was developed using nasal MucilAir™ (Epithelix) in vitro epithelium challenged by HIS. Two conditions were assessed in a side-by-side comparison: tissue was exposed to HIS + FEX with or without FEX pre-treatment (one-hour prior to HIS challenge). Tissue functionality, cytotoxicity, H1R gene expression, and inflammatory cytokines were assessed.

Results

HIS at 100 µM induced significant 3.1-fold and 2.2-fold increases for inflammatory biomarkers interleukin (IL)-8 and IL-6, respectively (p < 0.0001), as well as rapid upregulation of H1R mRNA. Inflammatory biomarkers were inhibited by FEX and H1R expression was significantly reduced (p < 0.0001). FEX alone decreased H1R expression at all doses tested. With one-hour FEX pre-treatment, there was significantly higher downregulation of IL-8 (p < 0.05) and further downregulation of H1R expression and IL-6 versus without FEX pre-treatment; the effects of FEX were improved from 22% to 40%.

Conclusion

A model of HIS-induced airway inflammation was established based on IL-8, IL-6 and H1R gene expression and was validated with FEX. FEX works as an inverse agonist, with a higher effect when used before+during versus only during the HIS challenge. Taking FEX before+during allergen exposure, or when symptoms first occur, may reduce basal activity and H1R gene expression, providing stronger protection against the worsening of symptoms upon allergen exposure.
Ginsenosides: an immunomodulator for the treatment of colorectal cancer
Authors: Qian Jianan , Jiang Yanyu , Hu Hongyi
Published: June 2024

Ginsenosides, the primary bioactive ingredients derived from the root of Panax ginseng, are eagerly in demand for tumor patients as a complementary and alternative drug. Ginsenosides have increasingly become a “hot topic” in recent years due to their multifunctional role in treating colorectal cancer (CRC) and regulating tumor microenvironment (TME). Emerging experimental research on ginsenosides in the treatment and immune regulation of CRC has been published, while no review sums up its specific role in the CRC microenvironment. Therefore, this paper systematically introduces how ginsenosides affect the TME, specifically by enhancing immune response, inhibiting the activation of stromal cells, and altering the hallmarks of CRC cells. In addition, we discuss their impact on the physicochemical properties of the tumor microenvironment. Furthermore, we discuss the application of ginsenosides in clinical treatment as their efficacy in enhancing tumor patient immunity and prolonging survival. The future perspectives of ginsenoside as a complementary and alternative drug of CRC are also provided. This review hopes to open up a new horizon for the cancer treatment of Traditional Chinese Medicine monomers.
Toward high-resolution modeling of small molecule–ion channel interactions
Authors: Harris Brandon J. , Nguyen Phuong T. , Zhou Guangfeng , Wulff Heike , DiMaio Frank , Yarov-Yarovoy Vladimir
Published: June 2024

Ion channels are critical drug targets for a range of pathologies, such as epilepsy, pain, itch, autoimmunity, and cardiac arrhythmias. To develop effective and safe therapeutics, it is necessary to design small molecules with high potency and selectivity for specific ion channel subtypes. There has been increasing implementation of structure-guided drug design for the development of small molecules targeting ion channels. We evaluated the performance of two RosettaLigand docking methods, RosettaLigand and GALigandDock, on the structures of known ligand–cation channel complexes. Ligands were docked to voltage-gated sodium (NaV), voltage-gated calcium (CaV), and transient receptor potential vanilloid (TRPV) channel families. For each test case, RosettaLigand and GALigandDock methods frequently sampled a ligand-binding pose within a root mean square deviation (RMSD) of 1–2 Å relative to the experimental ligand coordinates. However, RosettaLigand and GALigandDock scoring functions cannot consistently identify experimental ligand coordinates as top-scoring models. Our study reveals that the proper scoring criteria for RosettaLigand and GALigandDock modeling of ligand–ion channel complexes should be assessed on a case-by-case basis using sufficient ligand and receptor interface sampling, knowledge about state-specific interactions of the ion channel, and inherent receptor site flexibility that could influence ligand binding.
Multi-omic analysis reveals that Bacillus licheniformis enhances pekin ducks growth performance via lipid metabolism regulation
Authors: Li Lei , Yang Liangyu , Zhang Limei , He Fengping , Xia Zhaofei , Xiang Bin
Published: June 2024

Introduction:Bacillus licheniformis (B.licheniformis) was widely used in poultry feeds. However, it is still unclear about how B.licheniformis regulates the growth and development of Pekin ducks.

Methods: The experiment was designed to clarify the effect and molecular mechanism of B. licheniformis on the lipid metabolism and developmental growth of Pekin ducks through multiomics analysis, including transcriptomic and metabolomic analyses.

Results: The results showed that compared with the control group, the addition of 400 mg/kg B. licheniformis could significantly increase the body weight of Pekin ducks and the content of triglyceride (p < 0.05), at the same time, the addition of B. licheniformis could affect the lipid metabolism of liver in Pekin ducks, and the addition of 400 mg/kg B. licheniformis could significantly increase the content of lipoprotein lipase in liver of Pekin ducks. Transcriptomic analysis revealed that the addition of B. licheniformis primarily impacted fatty acid and glutathione, amino acid metabolism, fatty acid degradation, as well as biosynthesis and elongation of unsaturated fatty acids. Metabolomic analysis indicated that B. licheniformis primarily affected the regulation of glycerol phospholipids, fatty acids, and glycerol metabolites. Multiomics analysis demonstrated that the addition of B. licheniformis to the diet of Pekin ducks enhanced the regulation of enzymes involved in fat synthesis via the PPAR signaling pathway, actively participating in fat synthesis and fatty acid transport.

Discussion: We found that B. licheniformis effectively influences fat content and lipid metabolism by modulating lipid metabolism-associated enzymes in the liver. Ultimately, this study contributes to our understanding of how B. licheniformis can improve the growth performance of Pekin ducks, particularly in terms of fat deposition, thereby providing a theoretical foundation for its practical application.

Conclusion:B. licheniformis can increase the regulation of enzymes related to fat synthesis through PPAR signal pathway, and actively participate in liver fat synthesis and fatty acid transport, thus changing the lipid metabolism of Pekin ducks, mainly in the regulation of glycerol phospholipids, fatty acids and glycerol lipid metabolites.
A novel spreading dynamic based on adoption against the trend
Authors: Hao Jiaqi , Ma Jinming , Liu Siyuan , Tian Yang
Published: June 2024

In the spreading dynamics of previous fashion trends, adoption researchers have neglected to consider that some individuals may behave differently from popular tendencies, which is called opposite-trend adoption behavior. To explore the dissemination mechanisms of the behavior, we first establish the adoption-against-trend model. Additionally, an edge division theory based on the adoption of opposite trends was proposed to quantitatively analyze this unique dissemination mechanism. This study presents three different degrees of opposite trends, each highlighting unique spreading scenarios. In the case of a strong opposite trend, no spreading occurs. In the case of a weak opposite trend, limited contact will accelerate information spreading, but it will not alter the mode of spreading. Nevertheless, in the case of a moderately opposite trend, the degree of the opposite trend alters the mode of spreading. Meanwhile, a cross-phase transition occurs. The findings of this paper can be applied to various areas, including social media and commercial trades.
Dynamic prediction model of landslide displacement based on (SSA-VMD)-(CNN-BiLSTM-attention): a case study
Authors: Wang Rubin , Lei Yipeng , Yang Yue , Xu Weiya , Wang Yunzi
Published: June 2024

Accurately predicting landslide displacement is essential for reducing and managing associated risks. To address the challenges of both under-decomposition and over-decomposition in landslide displacement analysis, as well as the low predictive accuracy of individual models, this paper proposes a novel prediction model based on time series theory. This model integrates a Convolutional Neural Network (CNN) with a Bidirectional Long-Short Term Memory network (BiLSTM) and an attention mechanism to form a comprehensive CNN-BiLSTM-Attention model. It harnesses the feature extraction capabilities of CNN, the bidirectional data mining strength of BiLSTM, and the focus-enhancing properties of the attention mechanism to enhance landslide displacement predictions. Furthermore, this paper proposes utilizing the Variational Mode Decomposition (VMD) method to decompose both landslide displacement and its influencing factors. The VMD algorithm’s parameters are optimized through the Sparrow Search Algorithm (SSA), which effectively minimizes the influence of subjective bias while maintaining the integrity of the decomposition. A fusion of the Maximal Information Coefficient (MIC) and Grey Relational Analysis (GRA) is then employed to identify the critical influencing factors. The selected sequence of factors that conforms to the criteria is used as the input variable for displacement prediction via the CNN-BiLSTM-Attention model. The cumulative displacement prediction is derived by aggregating the results from each sequence. The study reveals that the SSA-VMD-CNN-BiLSTM-Attention model introduced herein achieves superior predictive accuracy for both periodic and random term displacements than individual models. This advancement provides a dependable benchmark for forecasting displacement in similar landslide scenarios.
A bibliometric analysis of endoplasmic reticulum stress and atherosclerosis
Authors: Huang Xinyu , Jiang Feng , Ma Yongbo , Zhu Kunpeng , Wang Zhenyuan , Hua Zhen , Yu Jie , Zhang Lei
Published: June 2024

The mechanisms underlying the occurrence and development of atherosclerosis (AS) are diverse, among which endoplasmic reticulum stress (ERS) is an important mechanism that should not be overlooked. However, up to now, there has been no bibliometric study on the relationship between ERS and AS. To understand the research progress in ERS and AS, this paper conducted a statistical analysis of publications in this field using bibliometrics. A total of 1,035 records were retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, and the R package “bibliometric” were used to analyze the spatiotemporal distribution, countries, authors, institutions, journals, references, and keywords of the literature, and to present the basic information of this field through visualized maps, as well as determine the collaboration relationships among researchers in this field. This field has gradually developed and stabilized over the past 20 years. The current research hotspots in this field mainly include the relationship between ERS and AS-related cells, the mechanisms by which ERS promotes AS, related diseases, and associated cytokines, etc. Vascular calcification, endothelial dysfunction, NLRP3 inflammasome, and heart failure represent the frontier research in this field and are becoming new research hotspots. It is hoped that this study will provide new insights for research and clinical work in the field of ERS and AS.
Quarterly fluctuations in external and internal loads among professional basketball players
Authors: Yang Kaiqi
Published: June 2024

Purpose

This study aims to explore the variations in external and internal loads on a quarter-by-quarter basis among professional Chinese basketball players. It emphasizes the crucial impact of these variations on optimizing athletic performance and match strategies.

Method

An observational longitudinal study design was employed, involving sixteen male players from the National Basketball League during the 2024 season in China. Data collection was facilitated through the use of Catapult S7 devices for measuring external loads and session ratings of perceived exertion (sRPE) for assessing internal loads. Linear mixed-effects models were utilized for the statistical analysis to identify differences in workload intensities across game quarters based on player positions. The Pearson correlation coefficient was used to examine the relationship between external and internal load throughout the game.

Results

The analysis uncovered significant positional differences in workload intensities across game quarters. Guards were found to have a higher PlayerLoad™ (PL) per minute in the first quarter, while centers demonstrated an increase in high-intensity accelerations and jumps in the fourth quarter. Furthermore, a significant moderate correlation between sRPE and PL was observed across all game quarters, indicating a link between physical exertion and athletes’ perceptions of effort.

Conclusion

The study offers new insights into the dynamic physical demands faced by basketball players and the importance of using both objective and subjective measures for a comprehensive assessment of athlete performance and wellbeing. The findings underscore the interconnectedness of physical exertion and athlete perception, providing a foundation for future research and practical applications in the field of basketball science.
Plastid phylogenomics contributes to the taxonomic revision of taxa within the genus Sanicula L. and acceptance of two new members of the genus
Authors: Song Bo-Ni , Liu Chang-Kun , Ren Ting , Xiao Yu-Lin , Chen Lian , Xie Deng-Feng , He An-Guo , Xu Ping , Fan Xing , Zhou Song-Dong , He Xing-Jin
Published: June 2024

Introduction

The genus Sanicula L. is a taxonomically complicated taxa within Apiaceae, as its high variability in morphology. Although taxonomists have performed several taxonomic revisions for this genus, the interspecific relationships and species boundaries have not been satisfactorily resolved, especially for those endemic to China. This study mainly focused on S. giraldii var. ovicalycina, S. tienmuensis var. pauciflora, and S. orthacantha var. stolonifera and also described two new members of the genus.

Methods

We newly sequenced sixteen plastomes from nine Sanicula species. Combined with eleven plastomes previously reported by us and one plastome downloaded, we performed a comprehensively plastid phylogenomics analysis of 21 Sanicula taxa.

Results and Discussion

The comparative results showed that 21 Sanicula plastomes in their structure and features were highly conserved and further justified that two new species were indeed members of Sanicula. Nevertheless, eleven mutation hotspot regions were still identified. Phylogenetic analyses based on plastome data and the ITS sequences strongly supported that these three varieties were clearly distant from three type varieties. The results implied that these three varieties should be considered as three independent species, which were further justified by their multiple morphological characters. Therefore, revising these three varieties into three independent species was reasonable and convincing. Moreover, we also identified and described two new Sanicula species (S. hanyuanensis and S. langaoensis) from Sichuan and Shanxi, China, respectively. Based on their distinct morphological characteristics and molecular phylogenetic analysis, two new species were included in Sanicula. In summary, our study impelled the revisions of Sanicula members and improved the taxonomic system of the genus.
Predicting the distribution pattern changes of dye plant habitats caused by climate change
Authors: Duan Jingpeng , Liu Jing , Huang Zhihuan
Published: June 2024

Climate change has accelerated the habitat loss and fragmentation of wildlife. Dye plants of “Fengxiang dyeing” are important indigenous natural resources for traditional printing and dyeing craft in southwest China, is of practical and cultural importance for dozens of ethnic minorities. However, lack of the spatial distribution information of these plants has hampered holistic and efficient conservation management measures. We analyzed the potentially suitable areas of four dye plants (Liquidambar formosana, Strobilanthes cusia, Persicaria tinctoria and Indigofera tinctoria) necessary for “Fengxiang dyeing” based on their geographical distribution sites under different climatic situations using the maximum entropy (MaxEnt) model. The results showed that temperature, precipitation and elevation were the most important factors affecting the suitable geographical areas of the four dye plants. Under the current climate conditions, the overlapping suitable habitat areas of the four plants were mainly in the four southern provinces of China, including Guizhou, Guangxi, Guangdong and Hainan. L. formosana was used as the base plant for combination with the other three plants under the two future climate scenarios (SSP126 and SSP585), and the overlapping suitable habitat areas of the obtained seven combination patterns were considered suitable for potential craft development. Five patterns showed an increase, while two patterns showed a decreasing trend with the increasing carbon emission. The prediction results showed that the overlapping suitable habitat center of the four plants will gradually move to the northeast, indicating that the overlapping suitable habitat area and craft distribution area will be changed. These results provide the basis for understanding the spatial distribution pattern changes of dye plants caused by climate change and establishing measures for protecting and developing printing and dyeing craft.
Oat—an alternative crop under waterlogging stress?
Authors: Pitann Britta , Mühling Karl H.
Published: June 2024

Introduction

Waterlogging is one vast environmental constraint that limits crop growth and yield worldwide. Most major crop species are very sensitive to waterlogging, leading to enormous yield losses every year. Much is already known about wheat, barley or maize; however, hardly any data exist on oat and its tolerance against waterlogging. Thus, this study aimed to investigate if oats can be an adequate alternative in crop rotation under conditions of temporal submergence and if cultivar differences exist. Furthermore, this study was to test (1) whether yield was differently affected when stress is applied at different developmental stages (BBCH 31 and 51), and (2) nutrient imbalances are the reason for growth restrictions.

Methods

In a large-scale container experiment, three different oat varieties were cultivated and exposed to 14 consecutive days of waterlogging stress at two developmental stages.

Results

Even though vegetative growth was impaired after early waterlogging and which persists till maturity, mainly due to transient nutrient deficiencies, growth performance after late waterlogging and grain yield of all three oat varieties at maturity was not affected. A high tolerance was also confirmed after late waterlogging in the beginning generative stage: grain yield was even increased.

Discussion

Overall, all oat varieties performed well under both stress treatments, even though transient nutrient imbalances occurred, but which were ineffective on grain yield. Based on these results, we conclude that oats, independently of the cultivar, should be considered a good alternative in crop production, especially when waterlogging is to be expected during the cultivation phase.
Field performance of grafted, micropropagated, and own-rooted plants of three Italian hazelnut cultivars during the initial four seasons of development
Authors: Traini Chiara , Facchin Simona Lucia , Brigante Raffaella , Vinci Alessandra , Persichetti Sofia , Meneghini Massimiliano , Micheli Maurizio , Famiani Franco , Portarena Silvia , Dradi Giuliano , Farinelli Daniela
Published: June 2024

Introduction

Over the course of four consecutive years, a comparative study, for the first time, was carried out to assess their growth characteristics, vegetative and productive performances.

Material

Micropropagated, grafted on not suckering rootstock and own-rooted plants by layering from three Italian hazelnut (Corylus avellana L.) cultivars were established in the same orchard and environmental condition.

Results

We found that the micropropagated plants, regardless of the variety considered, even being smaller than the other plants at the beginning of the plantation, reached similar sizes as the other plants after four growing seasons. Furthermore, micropropagated plants exhibited greater uniformity in growth compared to grafted ones, while own-rooted plants displayed more variability. No significant differences in yield performance and canopy volume were observed among the three propagation methods. These results suggest that the in vitro propagation technique, even in hazelnut, allows standardizing the plant material while preserving cultivar characteristics. Finally, in vitro propagation as well as grafting can be safely recommended for the cultivation of hazelnut cultivars.
Effects of geographical, soil and climatic factors on the two marker secondary metabolites contents in the roots of Rubia cordifolia L.
Authors: Wang Yanlin , Liu Huanchu , Yu Shuai , Zhang Yue , Huang Yanqing , He Xingyuan , Chen Wei
Published: June 2024

The growth and quality of medicinal plants depend heavily on environmental variables. The quality of Rubia cordifolia, an important medicinal plant, is determined by the two main secondary metabolites of the root, purpurin and mollugin. However, their relationship with environmental factors has not been studied. In this study, the purpurin and mollugin contents of R. cordifolia roots from different sampling sites in China were measured using ultra-high-performance liquid chromatography, and the correlations between the two secondary metabolites and environmental variables were analyzed. The results showed that there were significant differences in the contents of purpurin and mollugin in the roots of R. cordifolia at different sampling points. The content of purpurin ranged from 0.00 to 3.03 mg g-1, while the content of mollugin ranged from 0.03 to 10.09 mg g-1. The quality of R. cordifolia in Shanxi, Shaanxi and Henan border areas and southeastern Liaoning was higher. Liaoning is expected to become a R. cordifolia planting area in Northeast China. Correlation and regression analysis revealed that the two secondary metabolites were affected by different environmental factors, the two secondary metabolites contents were positively correlated with longitude and latitude, and negatively correlated with soil nutrients. In addition, higher temperature and shorter sunshine duration facilitated the synthesis of purpurin. Annual precipitation might be the main factor limiting the quality of R. cordifolia because it had opposite effects on the synthesis of two major secondary metabolites. Therefore, this study is of great significance for the selection of R. cordifolia planting areas and the improvement of field planting quality.
The roles of language and executive function in Mandarin-speaking children’s theory of mind development
Authors: Li Honglan , Leung Man-Tak
Published: June 2024

Introduction

Research has indicated that language and executive function relate closely to first-order false belief reasoning, yet their roles in second-order false belief reasoning are under-explored, and their interplay in theory of mind development remains obscure.

Methods

This study assessed 160 Mandarin-speaking preschoolers’ and early primary schoolers’ language, executive function, and theory of mind abilities to examine the unique roles and interplay of language and executive function in first-order and second-order false belief reasoning.

Results

Results showed that language significantly uniquely predicted the children’s first-order as well as second-order false belief reasoning when controlling for the effects of age and executive function. Although executive function significantly predicted first-order FB reasoning when controlling for age, it was no longer a significant predictor of first-order FB reasoning when language was included in the model. However, executive function played a significant unique role in second-order FB reasoning when controlling for the effects of age and language.

Discussion

The current findings suggest that language plays a greater role than executive function in Mandarin-speaking children’s theory of mind development and the contributors to theory of mind development vary in different levels of false belief reasoning.
Nature-based experience in Venetian lagoon: Effects on craving and wellbeing in addict residential inpatients
Authors: Benvegnù Giulia , Semenzato Mauro , Urbani Alberto , Zanlorenzi Isadora , Cibin Mauro , Chiamulera Cristiano
Published: June 2024

Introduction

It is known that exposure to the natural environment may positively modulate mental processes and behaviors; in particular, it can reduce stress, anxiety, and depressive symptoms. This suggests a potential integration of “nature experience” into the treatment for substance use disorder (SUD) since various types of addiction are associated with anxiety and depression. Considering that only one study has been reported to date in patients with alcohol use disorder, the effect of nature experience in SUD patients' needs to be further investigated. This study aimed to test the effects of exposure to a natural lagoon environment on craving and measures of wellbeing in SUD patients in comparison to exposure to an urban environment.

Methods

Twenty-four SUD patients were divided into three groups of eight participants and exposed to two walking sessions (interspersed with a 1-week wash-out period) in a natural environment typical of the Venetian lagoon, an Urban walk, or staying at the residential center based on a Latin-square design. Before and after each session, drug craving, mood, wellbeing, agency, openness to the future, and restorativeness were assessed.

Results

The Nature walk significantly decreased craving in participants compared to their pre-walk values, and compared to craving after the Urban walk, with the latter significantly increased vs. pre-walk values. The Nature walk significantly decreased negative mood and increased wellbeing and agency. Openness to the future and restorativeness measures showed significant improvement after the Nature walk compared to the Urban walk. On the other hand, craving scores after the Urban Walk positively correlated with negative mood and a Sense of Negative Agency values and negatively correlated with wellbeing scores.

Discussion

Our results confirm that “nature experience” may improve mood, wellbeing, attention, stress relief, openness, and sense of being active in SUD patients. Moreover, we also showed a specific effect on drug craving—a key symptom of SUD.
A systematic review of primary school teachers’ wellbeing: room for a holistic approach
Authors: Ozturk Mumine , Wigelsworth Michael , Squires Garry
Published: June 2024

Although the investigation of mental health and wellbeing in education has shown an exponential increase on an international scale, attention has primarily been paid to students, leaving the concept of teacher wellbeing comparatively overlooked. Extant literature offers numerous divergent descriptions, with some academics even avoiding an explicit definition of the term. Thus, there are limitations and inconsistencies in understanding teacher wellbeing as a unique construct. The aim of the current study was three-fold; (1) to assess the extent to which existing research reflects the multidimensional nature of the term teacher wellbeing, (2) to determine whether a holistic construct of teacher wellbeing could be justified, and (3) to evaluate the methodological quality of studies identified. A systematic review following the PRISMA statement was applied to peer-reviewed papers published between 2016 and 2021. Following the screening of 1,676 studies, this paper reports on findings drawn from a final sample of 61 articles conceptualizing teacher wellbeing. Studies were organized by their dominant discourses, namely negativity/ deficiency, positivity/ flourishing, and/or professionalism. Findings illustrate that teacher wellbeing was primarily conceptualized with a professionalism approach (with 18 of the identified studies taking solely this perspective). This is not completely consistent with the prior work that focused on stress and burnout (negativity/ deficiency approach) while exploring teachers’ mental health and wellbeing. More importantly, there were only 6 studies that considered all three discourses together. This paper argues that important information is lost through neglecting alternative lenses, requiring further attention in order to address teacher wellbeing comprehensively. Such an endeavor is essential for shaping interventions and strategies aimed not only at enhancing teacher wellbeing but also at improving student outcomes and, ultimately, the overall quality of education.

Systematic review registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278549PROSPERO, CRD42021278549.
Playfulness and adolescence: mentalization and neuropsychoanalysis perspective
Authors: Kolev Martin V.
Published: June 2024

The article attempts at conceptualizing the basic principles of how adolescents develop, getting out of childhood and proceeding to enter young adulthood. The age period of adolescence is marked with intense emotional states, lines of thinking, beliefs and transitions that caregivers often face challenges making sense of or mirroring. Combining mentalization-based approaches with neuropsychoanalytic findings about how basic emotional systems governing playful behavior work can shed additional light into the communication channels and specificities therapists might consider when engaging in such endeavor.
Survey of public knowledge, attitudes, and practices regarding personal protection against COVID-19 in the post-pandemic era
Authors: Luo Shixian , Xie Jing , Chen Jie , Li Hongyu , Zhang Sining
Published: June 2024

In the emerging post-pandemic era (the ‘wavelet’ era), humans must coexist with viruses for the foreseeable future, and personal protective behaviors will largely replace national-level preventive measures. In this new normal, encouraging the public to implement proper personal protective behaviors against the coronavirus disease (COVID-19) is vital to the sustainable development of cities and communities. This knowledge–attitude–practice (KAP) survey conducted in Chengdu (N= 900) narrowed the knowledge gap regarding post-pandemic public practices of protective behavior. Findings show that:(1) approximately 1/3 of the respondents are currently not concerned about COVID-19 at all; (2) respondents with different demographics and individual COVID-19-related factors showed significant differences in practice behaviors indoors and outdoors; (3) vulnerable groups performed better in practice behavior indoors/outdoors; (4) because the public may relax their vigilance outdoors, public places may become a transmission threat in the next outbreak; (5) attitudes are important, but limited incentives for practice; and (6) when knowledge increases beyond a threshold (68.75–75% in this study), protective behaviors decrease. Our results suggest that authorities must continue to educate and motivate the public, extending measures to cover personal protective practices, and have targeted policies for specific demographics to ensure equity in healthcare in the event of another pandemic (COVID-19 and alike crisis). Besides, comparing the results of the current study with similar studies conducted in other parts of the world can provide insights into how different populations respond to and adopt COVID-19 protective behaviors. The epidemiologists can use the data collected by this and other KAP surveys to refine epidemiologic models, which can help predict the spread of the virus and the impact of interventions in different settings.
Acute effects on the psychological perception of university students after participation in the “RegulACTION” workshop for the improvement of emotional health and promotion of an active lifestyle
Authors: Belando-Pedreño Noelia , Mendoza-Castejón Daniel , López Carlos E.
Published: June 2024

Introduction

Prospective research in Health Sciences and Sports Sciences warns of the need to design and implement educational program at the different stages of human development, that promote emotional competences, interpersonal competences, an adequate level of healthy physical activity as well as adherence to the Mediterranean diet and a more active lifestyle on a physical and social level. The main objective of the study was to design an intervention program on intra-and interpersonal competences together with emotional education, nutritional education and healthy physical activity, called ‘RegulACTION’.

Methods

The preliminary study sample consisted of 11 participants aged 21–28 years (M = 5.00, SD = 8.76) (8 female and 3 males) university students. An ad hoc questionnaire was elaborated to evaluate the participant’s perception of the usefulness of the ‘RegulACTION’ experience and a semi-structured interview of 5 questions to assess their perception, identification of their emotions, awareness of their cognitions, emotions and behaviors in the different areas of their lives.

Results

The descriptive results show that the participants are receptive to continuing training in the regulation of cognitions (thoughts) and emotions to increase their satisfaction in different areas of their lives. Regarding the qualitative results, the participants’ perception, collected verbatim, is that they feel the need to apply the knowledge about personal and social emotions, as well as healthy behavior in terms of nutrition and exercise, in their daily lives.

Discussion

The ‘RegulACTION’ program is designed based on the assessment of the prevalence of mental illness in the young adult and adult population, in line with the literature review in the area of knowledge of the theory of emotions, motivational theories and on the occasion of the development of a workshop organized.
Exploring the Singapore general population’s trust in COVID-19 information from different sources and its association with perceived risk of infection during the pandemic
Authors: Devi Fiona , Tan Bernard Chin Wee , Shafie Saleha , Zhang Yun Jue , Shahwan Shazana , Satghare Pratika , Chong Siow Ann , Subramaniam Mythily
Published: June 2024

Background

The degree of public trust in the government’s competence is crucial in preventing the spread of misinformation and reducing psychological distress during a pandemic. The study aimed to (i) explore the trust in COVID-19 information from different sources and trust in the ability of the World Health Organization (WHO), government departments and related institutions in handling the epidemic in Singapore and (ii) its association with perceived risk of infection among Singapore residents.

Methods

A total of 1,129 participants (aged 21 and above) were recruited from a cross-sectional study examining the well-being and resilience of Singapore’s population between May 2020 to June 2021. Trust in COVID-19 information from different sources was measured on a 10-point scale and an ordinal 7-point scale was used for perceived risk of infection. Descriptive statistics and multivariate logistic regression model were conducted.

Results

85.5% reported high trust in COVID-19 information from the government and their ability in handling the pandemic. Participants also reported high trust in COVID-19 information from local public health or infectious disease experts (84.4%) and traditional media (77.2%). Low trust in the ability of government departments and related institutions was associated with higher future (1 month) perceived risk of infection (OR: 5.7, 95% CI 1.02–32.45) and low trust in social media was associated with higher current perceived risk of infection (OR: 2.4, 95% CI 1.09–5.24).

Discussion

The present study provided insight on the level of trust on COVID-19 information from different sources and its associated perceived risks of infection. Future qualitative studies are recommended to facilitate better understanding of public trust and identify strategies for how it can be effectively addressed to support future public health responses.
The impact of infectious disease experience on household consumption: evidence from rural China
Authors: Han Linlin , Xue Xiaoling , Yu Jinxiang
Published: June 2024

Objective

The issue of low consumption among rural households in China has a longstanding history, and the experience of infectious diseases may exacerbate the existing challenges in fostering consumption growth. However, studies that characterize the impact of infectious diseases on household consumption are limited in China. This study aims to explore rural household consumption responses to infectious diseases post-assessment, and identify the underlying mechanisms.

Methods

A total of 1,539 rural households from China Family Panel Studies (CFPS) datasets of 2014, 2016, 2018, and 2020 were recruited as the study sample. The presence of infectious disease experience was employed as the independent variable and household consumption as the dependent variable. A panel fixed effects (FE) regression model was initially employed to identify the influence of infectious disease experiences on rural household consumption. The instrumental variable (IV) method was used to address potential endogeneity between independent and dependent variables. Robustness checks such as Propensity Score Matching (PSM) test were employed to ensure the reliability of the findings.

Results

The results reveal a statistically significant negative impact of infectious disease experiences on consumption over time, becoming no more significant at around 7–9 years post-disaster. This effect leads to more pronounced consumption deprivation for households with limited health insurance coverage and heightened healthcare resource constraints. The mechanism test indicates that infectious disease experiences affect the consumption levels of rural households through channels that include income constraints, the crowding-out of healthcare expenditure, and risk perception, with the precautionary savings motive acting as a moderator. Furthermore, the diminishing effect of infectious diseases on individual consumption surpasses that of natural disasters. Temporal discrepancy is observed in the impacts of infectious and chronic disease shocks on household consumption. The accumulation of liquid assets emerges as an effective strategy for households to mitigate the impact of infectious disease shocks.

Conclusion

The findings underscore the importance of integrating short- and long-term policies to bolster consumption capacity, strategically allocate inter-regional medical resources, and fortify the resilience of rural households against economic risks.
Surveillance of human leptospirosis infections in Ukraine between 2018 and 2023
Authors: Petakh Pavlo , Tymchyk Viktoriia , Kamyshnyi Oleksandr
Published: June 2024

Leptospirosis is a bacterial disease that affects both humans and animals worldwide. Currently, a positional war is ongoing in Ukraine, and the military is encountering a significant number of rodents in trenches and dugouts, which are known reservoirs for Leptospira, the causative agent of leptospirosis—a potentially dangerous infectious disease with a high mortality rate. The civilian population is also at potential risk of leptospirosis. The destruction of the Kakhovka Dam on June 6, 2023, has led to widespread devastation and human suffering. In the short term, there is a significant risk of rodent-borne diseases such as leptospirosis. We utilized data from the Ukrainian Centre for Disease Prevention Control and observed a substantial increase in prevalence in 2023. The notification rate in Ukraine in 2023 was 1.06 per 100,000 persons, which is higher than that of other countries in the European Union. Particular attention is being given to Zakarpattia Oblast, located on the western border of Ukraine, which shares boundaries with Romania, Hungary, Poland, and Slovakia, with an extremely high incidence rate of 12.08 per 100,000 persons. Based on these findings, we recommend education and awareness campaigns, vaccination, personal protective measures, and improved surveillance to address the increasing incidence of leptospirosis in Ukraine.
The impact of comorbidity status in COVID-19 vaccines effectiveness before and after SARS-CoV-2 omicron variant in northeastern Mexico: a retrospective multi-hospital study
Authors: Camacho-Moll Maria Elena , Mata-Tijerina Viviana Leticia , Gutiérrez-Salazar Carlos Cuauhtémoc , Silva-Ramírez Beatriz , Peñuelas-Urquides Katia , González-Escalante Laura , Escobedo-Guajardo Brenda Leticia , Cruz-Luna Jorge Eleazar , Corrales-Pérez Roberto , Gómez-García Salvador , Bermúdez-de León Mario
Published: June 2024

Introduction

The end of the coronavirus disease 2019 (COVID-19) pandemic has been declared by the World Health Organization on May 5, 2023. Several vaccines were developed, and new data is being published about their effectiveness. However, the clinical trials for the vaccines were performed before the Omicron variant appeared and there are population groups where vaccine effectiveness still needs to be tested. The overarching goal of the present study was to analyze the effects of COVID-19 vaccination before and after the Omicron variant in patients considering comorbidities in a population from Nuevo Leon, Mexico.

Methods

Epidemiological COVID-19 data from the Mexican Social Security Institute were collected from 67 hospitals located in northeastern Mexico, from July 2020 to May 2023, and a total of 669,393 cases were compiled, 255,819 reported a SARS-CoV-2 positive reverse transcription quantitative polymerase chain reaction (RT-qPCR) test or a positive COVID-19 antigen rapid test.

Results

Before Omicron (BO, 2020-2021), after 14 days of two doses of COVID-19 vaccine, BNT162b2 and ChAdOx1 vaccines were effective against infection in non-comorbid and all comorbid subgroups, whereas after Omicron (AO, 2022- 2023) there was no significant effectiveness against infection with none of the vaccines. Regarding hospitalization BO, BNT162b2, ChAdOx1, CoronaVac and mRNA-1273 significantly protected non-comorbid patients whereas BNT162b2, ChAdOx1, and mRNA-1273, protected all comorbid subgroups against hospitalization. AO, BNT162b2, ChAdOx1, CoronaVac and mRNA-1273 were effective against hospitalization in non-comorbid patients whereas for most comorbid subgroups BNT162b2, ChAdOx1 and CoronaVac were effective against hospitalization. Non-comorbid patients were protected against death as an outcome of COVID-19 during the BO period with most vaccines whereas a reduction in effectiveness was observed AO with mRNA-1273 vaccines in patients with hypertension, and diabetes mellitus.

Discussion

BO, COVID-19 vaccines were effective against infection, hospitalization, and death whereas AO, COVID-19 vaccines failed to protect the population from COVID-19 infection. A varying effectiveness against hospitalization and death is observed AO.
Care model selection for older adult stroke survivors with disabilities: insights from the eighth wave of CLHLS data and influencing factors
Authors: Xiang Liping , Liu Qin , Shi Zijuan , Zhang Li , Wu Li , Chen Yuqin
Published: June 2024

Background

Analyzing the differences in caregiving models for disabled older adult individuals after stroke and the influencing factors, to provide a basis for addressing relevant social demographic issues.

Methods

The older adult diagnosed with stroke were screened from the Chinese Geriatric Health Survey (CLHLS), and were further divided into subgroups of disability, which was based on their ability of or whether they need help in performing activities such as dressing, bathing, eating, toileting or bowel and bladder control using the international common Katz scale. The care model was divided into formal care, informal care and home care. Multivariate logistic regression was used to screen the influencing factors of the choice of care model for the disabled older adult after stroke.

Results

The results of univariate analysis showed that there were statistical differences in the choice of care mode among different ages, household registration types, number of children, years of education, degree of disability, community services, retirement pension, marital status and medical insurance. Multiple logistic regression showed that, The rural older adult with more children, shorter education years, living with spouse and no help from community tend to choose informal care. Older adult people with higher levels of education, urban household registration, and access to community services are more likely to choose formal care. Older adult women with multiple children are more likely to receive care from their children.

Conclusion

In the future, vigorous support for the development of formal caregiving institutions and the improvement of the management system of formal caregiving will help enhance the subjective initiative of disabled older adult individuals in choosing caregiving models and alleviate the burden of family caregiving.