bluuebunny/crossref_metadata_2025 huggingface dataset:
Seed dispersal mechanisms modulate Janzen-Connell effects in Mediterranean forests through antagonists and mutualists.
Authors: Perea Antonio Jesús , Wiegand Thorsten , Bastida Jesús , Pajares-Murgó Mariona , Cano Domingo , López-García Álvaro , Pomarede Lise , Prieto-Rubio Jorge , Rey Pedro , Garrido Jose Luis , Alcantara Julio
Published: October 2023

The Janzen-Connell hypothesis is one of the most important hypotheses in
ecology, but is mostly tested indirectly without accounting for the
underlying plant-associated organisms, or only for highly host-specific
organisms. Advances in massive sequencing allow to sample, for example,
the fungi communities associated with different plant species, and
spatial analysis can reveal spatial patterns in the number of organisms
(species) shared by plant species and their neighbours. We show how
combining these tools provides new perspectives for testing the Janzen
Connell hypothesis. We illustrate our approach using a natural
experiment in two fully-mapped Mediterranean forest plots, where the
dominant dry- and fleshy-fruited species have distinctly different seed
deposition patterns, leading to contrasting expectation about the
emerging spatial structures. Our analysis confirmed these expectations
and provided deep insights into how the neighbourhood load of
plant-associated fungi and herbivorous insects changes during plant
ontogeny and how seed dispersal mechanisms modulates Janzen-Connell
effects.
Reepithelialization of Diabetic Skin and Mucosal Wounds Is Rescued by Treatment With Epigenetic Inhibitors
Authors: Yang Bo , Alimperti Stella , Gonzalez Michael V. , Dentchev Tzvete , Kim Minjung , Suh Justin , Titchenell Paul M. , Ko Kang I. , Seykora John , Benakanakere Manju , Graves Dana T.
Published: October 2023

Wound healing is a complex, highly regulated process and is substantially disrupted by diabetes. We show here that human wound healing induces specific epigenetic changes that are exacerbated by diabetes in an animal model. We identified epigenetic changes and gene expression alterations that significantly reduce reepithelialization of skin and mucosal wounds in an in vivo model of diabetes, which were dramatically rescued in vivo by blocking these changes. We demonstrate that high glucose altered FOXO1–matrix metallopeptidase 9 (MMP9) promoter interactions through increased demethylation and reduced methylation of DNA at FOXO1 binding sites and also by promoting permissive histone-3 methylation. Mechanistically, high glucose promotes interaction between FOXO1 and RNA polymerase-II (Pol-II) to produce high expression of MMP9 that limits keratinocyte migration. The negative impact of diabetes on reepithelialization in vivo was blocked by specific DNA demethylase inhibitors in vivo and by blocking permissive histone-3 methylation, which rescues FOXO1-impaired keratinocyte migration. These studies point to novel treatment strategies for delayed wound healing in individuals with diabetes. They also indicate that FOXO1 activity can be altered by diabetes through epigenetic changes that may explain other diabetic complications linked to changes in diabetes-altered FOXO1-DNA interactions.

Article Highlights

FOXO1 expression in keratinocytes is needed for normal wound healing. In contrast, FOXO1 expression interferes with the closure of diabetic wounds. Using matrix metallopeptidase 9 as a model system, we found that high glucose significantly increased FOXO1-matrix metallopeptidase 9 interactions via increased DNA demethylation, reduced DNA methylation, and increased permissive histone-3 methylation in vitro. Inhibitors of DNA demethylation and permissive histone-3 methylation improved the migration of keratinocytes exposed to high glucose in vitro and the closure of diabetic skin and mucosal wounds in vivo. Inhibition of epigenetic enzymes that alter FOXO1-induced gene expression dramatically improves diabetic healing and may apply to other conditions where FOXO1 has a detrimental role in diabetic complications.
Randomized Trial of the Insulin-Only iLet Bionic Pancreas for the Treatment of Cystic Fibrosis– Related Diabetes
Authors: Sherwood Jordan S. , Castellanos Luz E. , O’Connor Mollie Y. , Balliro Courtney A. , Hillard Mallory A. , Gaston Sarah Grace , Bartholomew Rachel , Greaux Evelyn , Sabean Amy , Zheng Hui , Marchetti Peter , Uluer Ahmet , Sawicki Gregory S. , Neuringer Isabel , El-Khatib Firas H. , Damiano Edward R. , Russell Steven J. , Putman Melissa S.
Published: October 2023

OBJECTIVE

Cystic fibrosis–related diabetes (CFRD) affects up to 50% of adults with cystic fibrosis and adds significant morbidity and treatment burden. We evaluated the safety and efficacy of automated insulin delivery with the iLet bionic pancreas (BP) in adults with CFRD in a single-center, open-label, random-order, crossover trial.

RESEARCH DESIGN AND METHODS

Twenty participants with CFRD were assigned in random order to 14 days each on the BP or their usual care (UC). No restrictions were placed on diet or activity. The primary outcome was the percent time sensor-measured glucose was in target range 70–180 mg/dL (time in range [TIR]) on days 3–14 of each arm, and key secondary outcomes included mean continuous glucose monitoring (CGM) glucose and the percent time sensor-measured glucose was in hypoglycemic range <54 mg/dL.

RESULTS

TIR was significantly higher in the BP arm than the UC arm (75 ± 11% vs. 62 ± 22%, P = 0.001). Mean CGM glucose was lower in the BP arm than in the UC arm (150 ± 19 vs. 171 ± 45 mg/dL, P = 0.007). There was no significant difference in percent time with sensor-measured glucose <54 mg/dL (0.27% vs. 0.36%, P = 1.0), although self-reported symptomatic hypoglycemia episodes were higher during the BP arm than the UC arm (0.7 vs. 0.4 median episodes per day, P = 0.01). No episodes of diabetic ketoacidosis or severe hypoglycemia occurred in either arm.

CONCLUSIONS

Adults with CFRD had improved glucose control without an increase in CGM-measured hypoglycemia with the BP compared with their UC, suggesting that this may be an important therapeutic option for this patient population.
Re-epithelialization of Diabetic Skin and Mucosal Wounds is Rescued by Treatment with Epigenetic Inhibitors
Authors: Yang Bo , Alimperti Stella , V. Gonzalez Michael , Dentchev Tzvete , Kim Minjung , Suh Justin , M. Titchenell Paul , I. Ko Kang , Seykora John , Benakanakere Manju , T. Graves Dana
Published: October 2023

Wound healing is a complex, highly regulated process and is substantially disrupted by diabetes. We show here that human wound healing induces specific epigenetic changes that are exacerbated by diabetes in an animal model. We identified epigenetic changes and gene expression alterations that significantly reduce re-epithelialization of skin and mucosal wounds in an in vivo model of diabetes, which were dramatically rescued in vivo by blocking these changes. We demonstrate that high glucose altered FOXO1-MMP9 promoter interactions through increased demethylation and reduced methylation of DNA at FOXO1 binding sites and also by promoting permissive histone-3 methylation. Mechanistically, high glucose promotes interaction between FOXO1 and RNA polymerase-II (Pol-II) to produce high expression of MMP9 that limits keratinocyte migration. The negative impact of diabetes on re-epithelialization in vivo was blocked by specific DNA demethylase inhibitors in vivo and by blocking permissive histone-3 methylation, which rescues FOXO1-impaired keratinocyte migration. These studies point to novel treatment strategies for delayed wound healing in individuals with diabetes. They also indicate that FOXO1 activity can be altered by diabetes through epigenetic changes that may explain other diabetic complications linked to changes in diabetes-altered FOXO1-DNA interactions.
Ethical consumption values and ecological clothing: a study in brazil
Authors: Johann Daiane , Almeida Marcon Nora Gabriela , Severo Eliana Andrea
Published: October 2023

Objective: The research aims to investigate the Brazilian consumer in their intention to purchase ecological clothing.
Method: To carry out the study, field research was carried out, of an applied nature, with an exploratory and descriptive quantitative, cross-sectional objective, with non-probabilistic sampling, and research had for. The model proposed and validated by Echeverría (2017) was used as a basis, consisting of 11 factors and 42 psychographic observable variables, in addition to demographic variables (gender, age, education, and family income).
Originality/Relevance: As the concern for sustainability becomes a universal phenomenon, the profile of the ecologically conscious consumer evolves. The ecological fashion movement gained strength and several companies began to realize the importance of sustainability and ethical conduct as indispensable factors in fashion. Brazil is the largest complete textile chain in the West, with more than 9.5 million jobs.
Results: The predominance of the sample was female, education, there was a balance between the number of respondents between undergraduate and secondary education, with an average age of respondents of 36.74 years. An interesting point of the study, which proved to be quite significant, was the positive influence of the attitude toward the purchase of ecological products on the ecological purchase intention. The increase in ecological awareness greatly interferes with consumer behavior. The theory of planned behavior can explain this phenomenon, as an individual's attitude, their beliefs concerning a certain aspect, can influence their consumption intention.
Theoretical/methodological contributions: The contribution of this study is to provide the profile of the Brazilian consumer in their intention to purchase ecological clothing. The positive influence of the attitude towards the purchase of ecological products remained evident. Increased awareness of consumer behavior. The great contribution of this study lies in the proposition of a theoretical framework, which enables an understanding of the structure of green consumer behavior.
Social contributions: Assuming that human behavior is goal-oriented, based on individual beliefs, the goals TCP applied to consumption proposes that the way people select, process information, and act about them depends on the relevance and strength of its own general goals.
Penggunaan Metode Demonstrasi pada Pembelajaran Seni Budaya (Teater) di Kelas X E 1 SMA Negeri 7 Padang
Authors: Vanesa Abelita Khre , Susmiarti
Published: October 2023

Tujuan penelitian ini ialah untuk mendeskripsikan metode demonstrasi pada   pembelajaran seni budaya (teater) pada siswa kelas X E 1 SMA Negeri 7 Padang. Jenis  penelitian ini ialah penelitian kualitatif dengan metode deskriptif. Alat penelitian ialah peneliti sendiri, dan alat bantu seperti alat tulis dan kamera sangat membantu. Data  primer dan data sekunder dipakai pada bahan penelitian ini. Teknik pengumpulan data dilaksanakan melalui studi literatur, observasi, wawancara dan dokumentasi. Langkah-langkah menganalisis data ialah mengklasifikasi data, mengklarifikasi data, menganalisis data, mendeskripsikan data, dan menyimpulkan data. Hasil penelitian dan pembahasan disimpulkan kalau metode pembelajaran sudah sesuai dan hasil nilai peserta didik cukup meningkat. Pelaksanaan pembelajaran seni budaya (teater) dengan metode demonstrasi di kelas X E 1 SMA Negeri 7 Padang sangat berpengarauh kepada belajar peserta didik maka dari itu membantu akan meningkatnya kemauan belajar, pasrtisipasi dan hasil pembelajaran seni budaya (teater) di kelas X E 1. Meskipun masih ada siswa yang tidak mempresentasikan hasil monolog  sesuai dengan teknik yang telah ditentukan.
Pengaruh Financial distress, Karakteristik Komite Audit dan Kualitas Auditor Eksternal terhadap Manajemen Laba Akrual
Authors: Arista Salsabilla Putri , Serly Vanica
Published: October 2023

This study aims to examine the effect of financial distress, effectiveness audit committee, and external auditor quality on accruals earnings management. This type of research is causal associative with a quantitative approach. The data used is obtained from the annual reports of companies in the manufacturing listed on the Indonesia Stock Exchange 2017-2021. The sample selection method using purposive sampling obtained 435 samples from 87 companies. This study uses multiple linear regression analysis to test the hypothesis which is assisted by using the SPSS  program. The results show that audit committee meetings have a significant and negative effect on accruals earnings management, while financial distress, audit committee size, audit committee expertise, and external auditor quality not have significant effect on accruals earnings management.
Degradasi Zat Warna Rhodamin B menggunakan Katalis TiO2 dengan Metode Fotosonolisis
Authors: Aulia Wenti , Sanjaya Hary
Published: October 2023

Research has been carried out on the degradation of Rhodamine B dye with TiO2 as a catalyst using the photosonolysis method. The purpose of this study was to determine the optimum time and optimum mass of the TiO2 catalyst used to degrade rhodamine B. The results of the percentage degradation of rhodamine B were obtained from the absorbance value measured using a UV-Vis spectrophotometer. The maximum wavelength of rhodamine B obtained from the measurement of the UV-Vis spectrophotometer is 553.8 nm. The results showed that the optimum time to degrade rhodamine B was 210 minutes with a degradation percentage of 95.39%. On the effect of increasing the mass of TiO2 catalyst, the optimum mass of TiO2 is 0.05 grams with a degradation percentage of 93.44%.
Mirada hermenéutica al Trabajo Social contemporáneo
Authors: Yáñez Pereira Víctor R.
Published: October 2023

Este artículo se desarrolla en el marco del Postdoctorado en Trabajo Social de la Universidad Nacional de la Plata – Argentina, a partir de construcciones teórico-metodológicas derivadas de la investigación doctoral del autor, quien asume como foco de  análisis la matriz hermenéutica y el potencial de comprensión que la disciplina ostenta en su condición contemporánea. Desde esa base, se propone una lectura a los lenguajes de la investigación e intervención, enclave una lógica capaz de complejizar su  capacidad crítica y deconstructiva de la realidad. Se concluye que el posicionamiento de la profesión, en sus apuestas  sociopolíticas por el desarrollo de la sociedad, reclama fundamentos de una práctica intelectual contrahegemónica, que nos adentre en las tensiones e intersticios dejados por la cuestión social, sin alejarnos de lo real, lo concreto, lo cotidiano.
Analysis of the use of pop singing in musical theater singing based on data analysis
Authors: Li Weiling
Published: October 2023

In this paper, we first systematically sorted out the characteristics of pop singing and musical theater singing and explored the generation of emotion and melody application of pop singing in musical theater singing. Then, the gray GM(1,1) model is analyzed, and a gray data mining model based on data analysis is constructed to predict the application of pop singing in combination with the data mining model under data analysis. Finally, the prediction analysis was conducted to use characterization, timbre and style in pop singing, respectively. The results showed that the score of character building was 90, and the errors between the predicted and actual values of timbre and style were between ±0.1 and ±1, respectively, which were within an acceptable range.
Analysis of film distribution methods based on artificial intelligence technology
Authors: Zeng Rong , Zhang Hui
Published: October 2023

In this paper, we first sort out the common film communication media and film communication methods and explore the application of visual language and multimodal discourse analysis based on artificial intelligence in film communication. Then, the maximum flow belief propagation algorithm is designed by combining the belief algorithm based on the information propagation algorithm with the maximum flow linear programming equation, and the minimum cost of movie propagation methods based on artificial intelligence technology is designed. Finally, the accuracy, speed, and cost of the movie dissemination method using AI technology are analyzed by the MovieLens dataset. The results show that this dissemination method has the lowest MAE and RMSE values of 0.79 and 0.82, respectively, and the minimum average cost is 0.38 per person, which can be effectively disseminated.
Multimedia intelligent 3D images for automatic detection of sports injuries
Authors: Liu Hongyu
Published: October 2023

This paper uses the types and causes of sports injuries as the entry point to fuse 2D dynamic MRI with a 3D static motion for image alignment in multimedia 3D image plane technology. Using a weight-sharing network and convolution operation, sports injury features are extracted and fused, and a fusion detection framework for sports injury image features is created. Data analysis was conducted using an example to verify the detection framework’s effectiveness. The results show that the peak signal-to-noise ratio of acquiring athletes’ sports injury region imaging by the algorithm in this paper is 43 dB, and the average detection time is 5.91 s. The error control for sports injury detection was reduced from 0.102 to 0.011 after 600 iterations of the algorithm in this paper.
Research on digital design and experience of urban landscape based on parametric model
Authors: Xue Yujia , Zhao Yanyun
Published: October 2023

In this paper, according to the characteristics of parametric landscape design, practical landscape architecture is selected for parameter and rule sets, and then the program calculation is established by parametric software to realize the digital design of urban landscapes. The parametric model of urban architectural design is designed for site factor indexing, construction, and management of space and form. The automatic identification model based on the building plan for the construction of building functions is carried out to generate candidate target areas and location refinement analysis, and the parametric generation of the urban landscape is optimized for design. Compared to the initial scheme, the economic and technical indicators increased the volume ratio by 11.2%, the building density by 17.3%, and the green area ratio by 3.6%. The three performance indicators 1/VG̅, CHIS̅ and 1/VB̅ of Rop are 8.5%, 35.6% and 20.8%, respectively.
Construction of a secure storage and sharing model for medical data under computer network technology
Authors: Yin Peng , Yin Ting , Zhao Sijia , Yu Shan
Published: October 2023

This paper constructs a secure storage and sharing model of medical data based on the blockchain technology of computer network technology, and the model mainly designs the encryption process, storage process and sharing process of medical data. The model combines asymmetric encryption algorithm and ciphertext access strategy and designs a hybrid encryption method for secure storage and sharing of medical data through three stages: public parameters and key generation, encryption and decryption. The comprehensive performance of the constructed model is tested, and the security performance indexes are 0.998, 0.989, 0.996 and 0.993 and the execution time of the sharing mechanism is 1~16s, the data upload time is 1200ms, and the data download time is only 200ms.
Optimization Model Construction of Online Public Opinion Dissemination Based on Behavioral Data Mining
Authors: Yao Sijia
Published: October 2023

In this paper, we propose an optimization method based on behavioral data mining for the emergence of negative emotions in network public opinion in unexpected situations leading to problems that endanger social stability and use data mining to confirm the correspondence of the kNN algorithm. In the opinion propagation model, the radius of opinion radiation is assumed to use the network node density and distribution density as features of node exchange information. Then, the kNN algorithm is used to train the comment set for the analysis of user sentiment evolution of network opinion in the social network environment, and the web crawler technology is used to obtain the output interface data APIs of microblogs and WeChat, and the social media user comment data is used as the data for the empirical analysis of network opinion. snowNLP and kNN algorithms are used to analyze the sentiment score of network opinion and the sentiment score less than 0.5, i.e., the sentiment polarity. There were 15 days when the sentiment score tended to be negative and 65 days when the sentiment score was greater than 0.5, i.e., the sentiment polarity tended to be positive.
The effective path of ideological governance of university cyberspace in the context of big data
Authors: Shang Fengbiao
Published: October 2023

This paper analyzes the characteristics of university cyberspace ideology in the context of big data and the causes of risk formation and designs the index system of university cyberspace ideology governance at three levels: micro level, meso level and macro level. The combination of hierarchical analysis and entropy method is used to determine the weight of each evaluation index and establish the evaluation model of governance performance based on gray correlation analysis. After calculating the weights of ideological security in college cyberspace are 0.58, 0.52, 0.55, 0.55 and 0.53, the evaluation result of the constructed college cyberspace ideology governance system is 0.28, which is good.
A study on the strategy to improve the informatization teaching ability of teachers in higher education institutions based on OBE concept
Authors: Jia Man
Published: October 2023

This paper focuses on the outcome-oriented OBE concept and the teacher information-based teaching model. Then, a regression model was constructed to study teachers’ ability to teach in information technology, and the correlation between variables was studied using regression equations and significance tests. The influencing factors of teachers’ informatization teaching ability enhancement were studied through the indicators of teacher factor, school factor, and policy training, and the strategies of teachers’ informatization teaching ability enhancement in higher education institutions were proposed. The study showed that the overall mean value of teachers’ factors among the influencing factors was 4.09, and the mean values of motivation and self-efficacy were greater than 4 points. The overall mean value of school factors was 3.9, the overall mean value of policy training was 3.55, and the mean values of training, policy, and competition were all greater than 3. This study provides some references and ideas for improving teachers’ information technology teaching abilities in higher education institutions.
The integration of vocal music teaching and traditional music culture in colleges and universities with a full media perspective
Authors: bilige Gegen
Published: October 2023

The first part of this paper examines the classification of traditional music culture and the method of integrating it with modern vocal teaching. Then, the association rule algorithm was used to establish the calculation model of integrating college vocal teaching and traditional music culture, and the weighted MINWAL algorithm improved the model. Finally, the degree of integration and the effect of integration between college vocal music teaching and traditional music culture were analyzed using indicators of integration degree, value, and acceptance. The fusion levels of singing style, voice, tune melody, lyrics, performance technique and dynamics were 4, 3.5, 4.3, 4.4, 4.1 and 3.9, respectively. The fusion level regarding teaching content was 4.1, and the fusion level in terms of practical activities was 4.0. A teaching strategy that is feasible and effective and has promotion value is the combination of college vocal music teaching and traditional music culture.
Quality assessment of intelligent physical education teaching in universities based on multivariate statistical analysis and regression analysis
Authors: Li Bo , Guo Wei
Published: October 2023

In this paper, we first propose the basic technical support and service and management of university intelligent physical education composition, and on this basis, we propose a teaching quality assessment model based on multivariate statistical analysis and regression analysis. Among them, multivariate statistical analysis is used to calculate the factor loadings A of physical education teaching, and multiple linear regression is used to establish the teaching quality assessment model and test it. Finally, an empirical analysis of teaching quality assessment was conducted with smart physical education as an example. The results show that the comprehensive assessment value of smart physical education teaching quality based on a multiple linear regression model is very close to the actual value, and the error value ranges from [0.003 to 0.027]. The error values are smaller than [0.0135~0.0921] of the ANN model and [0.0635~0.1033] of the neural network model. The research in this paper can provide scientific quality assessment methods and theoretical support for smart physical education in colleges and universities to promote the development of smart physical education and improve teaching quality in colleges and universities.
Design and implementation of a startup business incubation platform based on VAR model
Authors: Ren Huixi
Published: October 2023

This paper first analyzes the startup incubation platform’s design requirements and builds the application system’s functional structure and architecture. Secondly, the technical analysis of the startup business incubation platform is carried out to model the complex system with multi-factor synergy using time series and capture the linear interdependence between multiple time series with the VAR model. Finally, the startup incubation platform design’s performance was tested. The results show that the system response time slows as the number of users increases, and the longest response time is 2.3 seconds when the number of users is 4000. It shows that the startup incubation platform meets the technical requirements and can fulfill the talent incubation needs of enterprises.
Study on the synergy between ecological landscape planning and architectural design in green building practice
Authors: Liao Bei , Anuar Ahmad Nazrin Aris Bin , Li Xiaoxian , Zhou Huihui
Published: October 2023

This paper analyzes the coupling relationship and coupling factors between ecological landscape planning and architectural design, combines ecological planning with landscape planning and design and explores the practical value of green architecture. The ecological landscape construction is divided into five systems, and three indicators with a high degree of influence on the health of the urban ecosystem are selected as the system influence factors to construct a healthy coupling synergy model of ecological landscape planning and architectural design. Taking Fujian Province as an example, we analyze the degree of coupling between ecological landscape planning and architectural design systems and the regional distribution of the level of coupling coordination in Fujian Province. The highest coupling coordination degree between ecological landscape planning and architectural design is R
10 and Rl for green buildings, with coupling coordination degrees of 0.8341 and 0.8001, respectively, and the lowest is R = 59 0.3854. Thus, it is important to synergize between architectural design and ecological landscape planning and construction.
Emotional design theory of digital art combined with perceptual machine model
Authors: Deng Ting , She Xing
Published: October 2023

The article begins by exploring the emotional design of brands in various categories and proposes a mathematical morphological visual perceptual machine model to implement emotional design. The model constructs a mathematical model capable of capturing and expressing emotional features through numerical sets. Point sets and images, and basic operations in image algebra. Finally, the influence of the applicable fields of brand digital art design, personal emotional needs, and personal experience needs on brand choice is analyzed. The entertainment industry and the Internet industry account for the largest share, each accounting for 30% and 29%, respectively. The influence of personal emotion on choosing a brand is more than 0.8, and the influence of personal experience on choosing a product is more than 0.6. The research results of this paper have certain practical and theoretical significance for the development of brand digital art design.
Study on the influence of vocational education on artisan skills personnel based on statistical methods
Authors: Xu Xinsen
Published: October 2023

This paper explores the multilayer linear relationship between vocational education and artisan skills talent based on a multilayer linear model using statistical methods. By dividing vocational education and artisan skills data into first and second layers, the limitations of traditional linearity or the problem of biased results can be effectively avoided. The multilayer correlation between vocational education and artisanal skills talents is explored by constructing an evaluation. Combining the variables and assignments of vocational education and skilled artisanal talents, the influence mechanism of vocational education on cultivating skilled artisanal talents is explored. The results show that the regression coefficients of vocational education input and students’ situation are high, 0.180 and 0.224, respectively, and significant at P<0.01 regarding the creative awareness of skilled artisan talents. Regarding students’ skill execution, the multi-layer regression coefficients were higher for students’ situation and vocational education input, respectively, at 0.239 and 0.179.
Examining the relationship between adult education participant engagement and learning effectiveness using statistical analysis
Authors: Xu Wenlong
Published: October 2023

In this paper, firstly, the process of building a statistical analysis model is studied in detail, the process of calculating the structural equation is described, and the structural equation algorithm is improved. A correlation model was created based on three dimensions: cognitive involvement, behavioral involvement, and affective involvement. After analyzing the model’s reliability and validity, it was modified to examine the correlation between learning engagement and effectiveness. The results showed that the overall effects of behavioral engagement, cognitive engagement, and affective engagement on key competencies were 0.978, 0.769, and -0.819, and the overall effects of behavioral engagement, cognitive engagement, and affective engagement on basic knowledge were 0.668, -0.569, and 0.586. The correlation between learning engagement and learning effectiveness was significant. This paper’s study has significant implications for educational reform in colleges and universities and for students to enhance their learning effectiveness.
Application of unsupervised machine learning algorithms to credit classification methods for tobacco retailers
Authors: Zhu Lili , Xiao Jun , Jiang Hao , Zhang Liang
Published: October 2023

This paper uses a clustering algorithm to extract and classify credit rating features of tobacco retailers and evaluates whether the classification results are reasonable by combining clustering evaluation indexes. The distance between samples is calculated using the similarity measure. The natural domain method density and peak clustering method are used to analyze the distribution of sample points in the data set. Combining the cluster analysis creates the tobacco retail credit rating evaluation index. The results show that cluster analysis can effectively extract credit rating features from tobacco retailers. When the number of features is 25, the model has the best classification effect, with a classification accuracy rate of 91.1%, a recall rate of 91.5%, and an F1 value of 91.3%. The classification of tobacco retailers’ credit ratings can be improved effectively by the research in this paper.
Design of an online interactive teaching platform for rural music education based on artificial intelligence
Authors: Zhang Yifan , Song Wei
Published: October 2023

This paper analyzes the elements of music curriculum based on artificial intelligence, reveals the nature of weighted linear regression through the nature of the weight function, and establishes a rural music education model using the weighted least squares method. According to the numerical characteristics of multidimensional random vectors, given multidimensional random vectors, the data set of the music teaching platform is set as the country music education indicator using the coordinate coefficient number vectors of each dimension of teaching. It was found that the passing rate of learning ability in the rural music education interactive teaching platform was as high as 97%, and schools should make full use of artificial intelligence technology to promote the better application of the interactive teaching platform in music online education and provide an effective way for rural primary and secondary school music education.
Analysis and Comparison of Limitation Interests in Civil Procedure Law in the Context of Information Technology
Authors: Shen Baosheng
Published: October 2023

This paper first discusses the application of text mining techniques in public security, with the research focus on case classification, feature extraction, and collusion analysis in civil litigation. A plain Bayesian-based first-level classifier is proposed to accurately classify first-level case texts. For all second-level case category document sets, keyword cooccurrence mapping is used to replace word frequency as a metric for feature selection, and a second-level classifier is constructed using a simple vector distance algorithm. Finally, the impact of time-barred benefit abandonment and time-barred benefit loss on the evolutionary system in civil litigation is investigated in depth using the pilot water tax reform in Hunan Province as a case study. The results show that when one of the subjects chooses to discard the statute of limitations benefits, x and y show a trend of steadily increasing convergence to 1 from the initial point, and the final stabilization point tends to (1,1). This paper aims to provide references and suggestions for reforming information and optimizing civil litigation.
Guided Endodontic Access Cavity of Maxillary Obliterated Pulp Canal Lateral Incisor
Authors: Krsoum Majid , Thobaiti Sabri , Hefne Mohammed
Published: October 2023

Background:
Managing severe calcified teeth in endodontics seems to be challenging for clinical, so static and dynamic guided endodontics ware developed to reduce the professional stress, increasing the patient\'s comfort, gives shorter clinical or procedural sessions with minimal invasive approach, and predictable canal location to avoid iatrogenic mishaps to be happened.
Case Presentation:
Preoperative investigations were conducted, tooth #12 had calcified chamber. Cone beam computed tomography (CBCT) was taken (Sirona GALILEOS Comfort CBCT scanner) showed that the coronal third of root canal is obliterated. For Guide planning, maxillary alginate impression was taken and scanned by digital scanner (smart optics - Vinyl High Resolution). Digital planning was done by 3Shape Implant Studio Software using sleeve size 3.5 mm (external diameter). Guided was printed by Digital Light Processing (DLP) 3d printing machine (NextDent 5100 3D printer). Enamel drilling by diamond round bur, guide was adapted to mouth and drill through until reach to 10 mm, periapical radiograph was taken to confirm the drilling depth.
Conclusion:
Guided treatment modality is not only used for anterior teeth or initial endodontic treatment, for posterior teeth and re-treatment endodontic cases as well. Finally, guided endodontic should be considered as mandatory treatment modality for pulp canal obliteration.
Studi Korelasi Pendidikan dan Lama Kerja dengan Praktik Kolaborasi Interprofesi di Instalasi Gawat Darurat
Authors: Widyastuti Dwi , Aditya Rizky , Milkhatun Milkhatun
Published: October 2023

Interprofessional collaboration is the collaboration of healthcare professionals from different professional backgrounds with patients and their families to provide quality care. As for the implementation of collaborative practice, especially nurses, it can be influenced by education and years of service. Both of these can affect skills and abilities in taking action and being able to think critically and easily make decisions. The goal of this study was to determine the relationship between education and length of work of nurses with the practice of interprofessional collaboration in the emergency department. This study uses a quantitative method with a cross-sectional approach, which measures the independent variable (education and length of service) and the dependent variable (interprofessional collaboration practices) simultaneously. The results of the data obtained by nurses with D3 nursing education were 43 people (79.6%) and 11 nurses (20.4%), while for length of work ≤ 5 years 9 people (16.7%) and ≥ 5 years 45 people ( 83.4%). The results of the bivariate test using the Kendall Tau formula obtained a correlation coefficient of 0.715 and a p-value of 0.050. So it can be concluded that there is a relationship between education and length of work of nurses with the practice of interprofessional collaboration in the Emergency Room. There needs to be an increase in the further education level of nurses and clear policies and regulations are needed in carrying out inter-professional collaboration practices.
Classification of intracranial tumors based on optical-spectral analysis
Authors: Romanishkin I. D. , Savelieva T. A. , Ospanov A. , Linkov K. G. , Shugai S. V. , Goryajnov S. A. , Pavlova G. V. , Pronin I. N. , Loschenov V. B.
Published: October 2023

The motivation for the present study was the need to develop methods of urgent intraoperative biopsy during surgery for removal of intracranial tumors. Based on the experience of previous joint work of GPI RAS and N.N. Burdenko National Medical Research Center of Neurosurgery to introduce fluorescence spectroscopy methods into clinical practice, an approach combining  various optical-spectral techniques, such as autofluorescence spectroscopy, fluorescence of 5-ALA induced protoporphyrin IX, diffuse reflection of broadband light, which can be used to determine hemoglobin concentration in tissues and their optical density, Raman spectroscopy, which is a spectroscopic method that allows detection of various molecules in tissues by vibrations of individual characteristic molecular bonds. Such a variety of optical and spectral characteristics makes it difficult for the surgeon to analyze them directly during surgery, as it is usually realized in the case of fluorescence methods – tumor tissue can be distinguished from normal with a certain degree of certainty by fluorescence intensity exceeding  a threshold value. In case the number of parameters exceeds a couple of dozens, it is necessary to use machine learning algorithms  to build a intraoperative decision support system for the surgeon. This paper presents research in this direction. Our earlier statistical analysis of the optical-spectral features allowed identifying  statistically significant spectral ranges for analysis of diagnostically  important tissue components. Studies of dimensionality reduction techniques of the optical-spectral feature vector and methods of clustering of the studied samples also allowed us to approach the implementation  of the automatic classification method. Importantly, the classification task can be used in two applications  – to differentiate between different tumors and to differentiate between different parts of the same (center, perifocal zone, normal) tumor. This paper presents the results of our research in the first direction. We investigated the combination of several methods and showed the possibility of differentiating glial and meningeal tumors based on the proposed optical-spectral analysis method.
Ethics and Accountability in Government Bureaucracy
Authors: Mendy Ousu
Published: October 2023

In recent years, the issues of ethics and accountability within government bureaucracies have remained both contentious and highly relevant to governance. This research offers a comprehensive analysis of the role of ethics and accountability in these bureaucracies, with a particular focus on transparency. Using a normative research methodology and secondary data collection, the research draws on literature such as books, journals, and theses to clarify the current and prevailing conditions within government bureaucracies. The findings indicate that accountability among government bureaucrats can be effectively achieved by imposing multiple and dynamic obligations on both administrators and lower-level bureaucrats. Furthermore, the research suggests that ethics can often be more significant than the law itself, as ethical principles motivate individuals to act morally based on what is right, whereas the law deters behavior primarily through the threat of penalties.
Process of Preparing 3-methyl-6-nitro-1H-indazole by Scale of 180 g/batch as an Important Intermediate for the Preparation of Pazopanib
Authors: Nguyễn Văn Hải , Bùi Thị Thanh Châm , Phan Quốc Hùng , Trần Trà Ly , Nguyễn Thị Ngọc , Bùi Thị Luyến , Nguyễn Thu Quỳnh , Đào Nguyệt Sương Huyền , Nguyễn Đình Luyện , Nguyễn Văn Giang
Published: October 2023

Pazopanib hydrochloride, marketed worldwide under the brand name Votrient, is an anti-cancer medication manufactured by Novartis. It is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma (STS). In previous studies, we presented initial results regarding the synthesis of 3-methyl-5-nitro-2H-indazole (3) as an important indazole component on a laboratory scale (approximately 10 g/batch). In this study, we have successfully synthesized this compound (3) at a scale of 200 g/batch, achieving an overall process yield of 79.6 % from the starting material ethylaniline. This yield is higher than that reported in previous publications. Some of the technical conditions that have been improved include optimizing the amount of sulfuric acid in the nitration reaction, the amount of acetic acid, sodium hydroxide in the diazotization reaction for ring closure, reaction temperature, and the feed method to control the reaction safely and achieve high efficiency at a scale of 200 g/batch.
PERFIL SOCIODEMOGRÁFICO E FRAGILIDADE DE PRONTUÁRIOS DE IDOSOS ATENDIDOS EM UMA UNIDADE BÁSICA DE SAÚDE
Authors: Prada Isabela Aparecida Gonçalves , Soares Gabriela Garcia , Caetano Mariana Donadon , Duarte Joyce Mara Gabriel , Nicolussi Adriana Cristina
Published: October 2023

Objetivo: identificar o perfil sociodemográfico de idosos de uma Unidade Básica de Saúde e detectar o provimento de informações nos prontuários da unidade. Métodos: Estudo quantitativo, descritivo, retrospectivo, realizado em uma Unidade Básica de Saúde de um município do Triângulo Sul de Minas Gerais. A coleta de dados ocorreu de abril a agosto de 2021, após amostragem probabilista com prontuários físicos e eletrônicos de idosos atendidos em 2019/2020. Foi utilizado instrumento validado por juízes contendo variáveis sociodemográficas e realizado análise descritiva. Resultados: A amostra foi composta por 448 prontuários, predominaram mulheres, brancas, aposentadas, casadas/com companheiro(a), com ensino fundamental incompleto, que não faziam uso de bebida alcoólica e não fumantes. Na maioria destas variáveis, havia ausência de informações nos prontuários. Conclusões: A falta de dados chama a atenção ao reconhecer fragilidades no provimento de informações de saúde da população nos prontuários desta unidade.
ESSENTIAL OILS AS NATURAL FOOD ADDITIVES: STABIL-ITY AND SAFETY
Authors: Frederico Camila , Franciscato Lidaiane Mariáh Silva dos Santos , Pereira Ruiz Suelen
Published: October 2023

Essential oils are volatile aromatic liquids derived from the secondary metabolism of plants, consisting of a complex mixture of different active compounds. Several medicinal plants are sources for the extraction of essential oils, being recognized as safe (GRAS) by the FDA (Food and Drug administration). The use of essential oils as possible food preservatives has been gaining ground in research due to their antioxidant and antibacterial activities, important characteristics in food preservation and also to the population's interest in consuming healthier products. Essential oils are a promising alternative for the food industry, as they act to control pathogenic and deteriorating bacteria. Compared to synthetic chemical preservatives, essential oils are generally safer, but have low stability, so encapsulation is a way to protect them from adversities. This review aims to demonstrate the effectiveness, stability and safety of essential oils and their use in food matrices.
ATENÇÃO À SAÚDE MENTAL DE MULHERES TRANSGÊNEROS: ASPECTOS POSITIVOS E NEGATIVOS
Authors: Pereira Stephannia Borges , Sousa Johnatan Martins , Farinha Marciana Gonçalves , Stefanini Jaqueline Rodrigues , Silva Nathália dos Santos , Dos Santos Paulie Marcelly Ribeiro , Teles Sheila Araújo , Caixeta Camila Cardoso
Published: October 2023

Objetivo: compreender os pontos positivos e negativos na assistência à saúde mental às mulheres transgêneros na atenção psicossocial. Método: pesquisa descritiva e exploratória qualitativa, com participação de três mulheres transgênero assistidas por três Centros de Atenção Psicossocial Álcool e Drogas (CAPSad) de um município da região central do Brasil. Realizaram-se entrevistas individuais semiestruturadas, submetidas à análise de conteúdo temática. Resultados: pontos positivos são: bom relacionamento interpessoal, variedade de atividades terapêuticas, aceitação, atenção e respeito à singularidade das usuárias, a continuidade do cuidado em liberdade e o encaminhamento para o processo de transexualização. Os pontos negativos são: relacionamento interpessoal terapêutico ineficaz de alguns profissionais, tempo de acolhimento noturno reduzido e poucas atividades manuais. Considerações finais: a pesquisa evidencia que apesar das potencialidades do cuidado a mulheres transgênero, os pontos negativos reforçam que os profissionais que atuam em CAPSad necessitam de educação permanente em saúde pautada na lógica de cuidado psicossocial.
ACOMPANHAMENTO DERMATOLÓGICO DE ENFERMAGEM NA ESTRATÉGIA SAÚDE DA FAMÍLIA: UM RELATO DE EXPERIÊNCIA
Authors: Silva Ísis de Siqueira , Araújo Thaís Luana de Lima , Dos Santos Jardel Marcelle , Peixoto Juliane Berenguer de Souza , Xavier Pedro Bezerra , Brandão Gisetti Corina Gomes , de Negreiros Rosângela Vidal , Grismino Thaynara Figueirêdo
Published: October 2023

O desenvolvimento de lesões por pressão vem sendo um tema bastante discutido dentro e fora do âmbito hospitalar, sendo considerado um indicador de qualidade da assistência hospitalar, quando o aparecimento ocorre mediante uma internação. Cabe ao enfermeiro o acompanhamento dermatológico, avaliação e prescrição de coberturas e correlatos, consoante o estágio da lesão por pressão. Por esta razão, este estudo teve como objetivo descrever a experiência de graduandos de enfermagem durante acompanhamento dermatológico de uma pessoa idosa. Trata-se de um estudo descritivo do tipo relato de experiência realizado entre os meses de fevereiro e maio de 2021. Através da experiência relatada neste estudo, foi possível compreender a complexidade e relevância do cuidado humanizado, e os desafios enfrentados pelo enfermeiro da Estratégia Saúde da Família nos cuidados à pessoa idosa com lesão por pressão. Do ponto de vista acadêmico, essa experiência proporcionou aos alunos confrontar os conhecimentos teóricos acerca do assunto, além de incorporar a importância do olhar holístico para o usuário.