bluuebunny/crossref_metadata_2025 huggingface dataset:
A Twitter-Based Analysis Of Hashtag And Mention Actions As An İndicator Of Turkish General Elections’ Outcomes
Authors: ABANOZ Enes
Published: June 2020

Social media provides a
large-scale data that have substantial prospective to define collective actions
such as social trends, political participation and complex phenomena in real
world. When people use these channels, they leave a huge amount of digital
trace that can be easily reached by researchers. This digital trace bestows us
a unique possibility to observe and reveal collective actions at unpreceded
measures. In this research, we have aimed to test if
the daily Twitter activities (tweet, retweet, mention) can serve as a
significant indicator regarding Turkish election results, an argument already
engaged in previous studies. We have concluded that some of our results overlap
with previous studies. The correlation between the daily attention volume on
acquired in this study and the election results –even though it does not
directly impact the election results– shows Turkish Twitter data can be used as
a proxy tool.
Particle Flow for tracking
Authors: Israel Louis
Published: June 2020

Target following is a difficult undertaking and by and large no explanatory arrangement is accessible, particularly for the multi-target following frameworks. To address this issue, likelihood theory thickness (PHD) channel is utilized by proliferating the PHD rather than the full multi-target back. As of late, the molecule stream channel dependent on the log homotopy gives another approach to state estimation. In this paper, we propose a novel successive Monte Carlo (SMC) execution for the PHD channel helped by the molecule stream (PF), which is called PF-SMC-PHD channel. Test results show that our proposed channel has higher exactness than the SMC-PHD channel and is computationally less expensive than the Gaussian blend PHD (GM-PHD) channel.
Left-Partial Isometries over Canonical Factors
Authors: Bolton Amanda
Published: June 2020

Let $\hat{\gamma} > \infty$. Recently, there has been much interest in the classification of maximal isomorphisms. We show that $q = \mathcal{{J}}''$. Is it possible to derive orthogonal measure spaces? In this context, the results of \cite{cite:0} are highly relevant.
Analisis Dinamik Model Matematika Penyebaran Populasi Perokok
Authors: Pomalingo Rafika , Resmawan Resmawan , Nurwan Nurwan
Published: June 2020

Rokok adalah salah satu zat kimia yang berpengaruh buruk bagi kesehatan dan lingkungan, mengakibatkan penyakit jantung, hipertensi, kanker dan berbagai penyakit lainnya. Dalam artikel ini dibahas tentang model matematika tipe SEIRS pada penyebaran populasi perokok. Model ini melibatkan empat sub populasi saling berinteraksi yaitu Susceptible (S) individu sehat tapi rentan menjadi perokok,Exposed (E) individu perokok kadang-kadang, Infected (I) individu perokok aktif, dan Recovered (R) individu yang berhenti menjadi perokok. Model yang dikonstruksi, memiliki dua titik kesetimbangan yaitu titik kesetimbangan bebas perokok dan titik kesetimbangan endemik. Selanjutnya bilangan reproduksi dasar (R0) sebagai nilai ambang batas terjadinya penyebaran perokok ditentukan menggunakan pendekatan matriks Next Generation. Titik kesetimbangan yang dianalisis dengan kriteria Rout-Hurwitz menunjukan sifat asimtotik lokal, dengan R0 < 1 untuk titik kesetimbangan bebas perokok dan R0 > 1 untuk titik kesetimbangan endemik. Hal ini didukung dengan simulasi yang menunjukan populasi stabil disekitar titik kesetimbangan bebas perokok dengan R0 < 1 dan stabil disekitar titik kesetimbangan endemik dengan R0 > 1
Cyber Security Challenges in Smart Grids
Authors: Khan Hasnaat
Published: June 2020

Research shows Cyber security challenges in Smart Grids
EuroRxiv: a European open science repository
Authors: Moustafa Khaled
Published: June 2020

Open and free access to scientific knowledge keeps scientists up to date with the latest achievements in their respective fields and to help set up appropriate solutions to health, environmental and technical issues. One of the efficient settings toward this purpose is the use of preprint servers- open repositories that allow authors to post their manuscripts ahead of formal peer review/publishing in traditional journals. The recognition of preprints as an essential part of science landscape are on the rise worldwide.In 2018, a European funder coalition, called Coalition S, has been formed and issued an open access plan, called Plan S, that requires authors of studies funded by the Coalition to publish their manuscripts- starting from January 2021- in open access journals or repositories that meet the guidelines of the Plan S. Many publishers and researchers welcomed the Plan S as a step forward to promote openness and free access to publicly funded research. To further enhance the open and free science movement, I'd propose a European preprint server called "European arXiv" (https://eurorxiv.eu) as a multidisciplinary and multilingual repository that will accept manuscripts (preprints and postprints) in the various European languages and beyond. The project is an individual initiative, but interested people are welcome to join.
Network structures of symptoms from the Zung Depression Scale
Authors: Briganti Giovanni , Scutari Marco , Linkowski Paul
Published: June 2020

The Self-rating Depression Scale (SDS) is a psychometric tool composed of 20 items used to assess depression symptoms. The aim of this work is to perform a network analysis of this scale in a large sample composed of 1090 French-speaking Belgian university students. We estimated a regularized partial correlation network and a Directed Acyclic Graph for the 20 items of the questionnaire. Node predictability (shared variance with surrounding nodes in the network) was used to assess the connectivity of items. The network comparison test was performed to compare networks from female and male students. The network composed of items from the SDS is overall positively connected, although node connectivity varies. Item 11 (“My mind is as clear as it used to be”) is the most interconnected item. Networks from female and male students did not differ. DAG reported directed edges among items. Network analysis is a useful tool to explore depression symptoms and offers new insight as to how they interact. Further studies may endeavor to replicate our findings in different samples, including clinical samples to replicate the network structures and determine possible viable targets for clinical intervention.
Assessment and Communication of Uncertainty in Intelligence to Support Decision Making: Final Report of Research Task Group SAS-114
Authors: Mandel David R.
Published: June 2020

This is a postprint of the 20-chapter final report of the NATO SAS Research Technical Group on Assessment and Communication of Uncertainty in Intelligence to Support Decision-Making.
The Effect of Legislature Size on Public Spending: A Meta-Analysis
Authors: Freire Danilo , Mignozzetti Umberto Guarnier , Roman Catarina , Alptekin Huzeyfe
Published: June 2020

In a seminal article, Weingast et al. (1981) argue that there is a positive relationship between legislature size and inefficiency in public expenditures. Their proposition is currently known as the "law of 1/n" and has been widely debated in political science and public administration. However, recent studies have questioned the validity of the theory. In this letter, we conduct the first meta-analysis that assesses the generality of the "law of 1/n". Based on a sample of 30 articles, we find no robust evidence suggesting that legislature size has either a positive or a negative effect on government budgets. Yet the aggregate results mask considerable heterogeneity. Our findings provide moderate support for the "law of 1/n" in unicameral legislatures and in upper houses, but they also indicate that papers using panel/fixed-effects models or regression discontinuity designs report negative public spending estimates. We find only limited evidence that electoral systems impact public spending, which suggests that proportional representation systems may not be more prone to overspending than majoritarian ones.
Difficult partnership: Turkey – EU. Chances, aspirations and barriers
Authors: Khorshid Hawzhen Kamal
Published: June 2020

The article deals with the admission of Turkey into the structures of the European Union, as a country located in only a small part in Europe but at the same time constituting a strategic location from the point of view of EU security. The time frame of the analysis made here basically covers the whole period of accession negotiations, but due to the length of the negotiations, only the most important elements will be emphasised (beginning of the accession process, its subsequent stages, problems). The aim of the article is to point out the opportunities and barriers to this accession, whose vision moves away because of Turkey’s deepening political crisis triggered by president Recep Tayyip Erdoğan. The main thesis of the article is the statement that the negotiation process, which started years ago, was inhibited and slowed down as a result of subsequent events taking place both in the EU (migration crisis) and in Turkey itself (military coup of 2016). The author wants to answer two questions: (1) what problems, over the years of accession negotiations, proved to be insurmountable in this process? and (2) what prospects for Turkey’s accession are drawn on the basis of the current positions of both negotiating parties? Empirics in this case must be based on an analysis of the history of the Turkish accession process and the most current media reports (mainly on the 2016 coup)
The Ostpolitik of Francoist Spain
Authors: Orella José Luis
Published: June 2020

Francoist Spain was not recognised by the Communist Bloc countries due to its support of the communities of political exiles. In 1969 a thaw in relations began at an economic level in search of markets for Spanish development. The timid contact would gradually increase and favour relationships away from political ideology, beneficial in economic terms, and this would prepare the basis of full future recognition, with the exchange of ambassadors in 1977.
Who Doesn’t File a Tax Return? A Portrait of Non-Filers
Authors: Robson Jennifer , Schwartz Saul
Published: June 2020

The Canada Revenue Agency administers dozens of cash transfer programs that require an annual personal income tax return to establish eligibility. Approximately 10–12 percent of Canadians, however, do not file a return; as a result, they will not receive the benefits for which they are otherwise eligible. In this article, we provide the first estimates of the number and characteristics of non-filers. We also estimate that the value of cash benefits lost to working-age non-filers was $1.7 billion in 2015. Previous literature suggests either a rational choice model of tax compliance (in which the costs of filing are weighed against its benefits) or a more complex behavioural model. Our study has important consequences for policy-making in terms of the administrative design and fiscal costs of public cash benefits attached to tax filing, the measurement of household incomes, and poverty rates.
Repair of Ruptured Sinus of Valsalva Aneurysm: Rare Cause of Acute Onset Congestive Heart Failure in Down’s Syndrome
Authors: Juaneda Ignacio , E. Contreras Alejandro , R. Peirone Alejandro , Juaneda Ignacio
Published: June 2020

A 20-year-old boy with Down´s syndrome presented to the emergency department with new onset acute
heart failure. Right side chest effusion and cardiomegaly was observed on chest x-ray. A mobile aneurysmal
sac protruding into the right atrium was detected and a ruptured aneurysm of the right coronary sinus of
Valsalva was observed in transthoracic echocardiogram. Cardiac angiography catheterization confirmed the
diagnosis. Surgical repair consisting of aneurysm resection and defect closure was performed shortly after
with pericardium reinforced suture through the right atrium. The patient was discharged uneventfully.
ANALISIS FAKTOR PENYEBAB KESULITAN BELAJAR MATEMATIKA PADA SISWA SDN 01 NANGA KANTUK
Authors: Andri Andri , Dores Olenggius Jiran , Lina Anastasia Helina
Published: June 2020

Penelitian ini bertujuan untuk mengetahui faktor penyebab kesulitan belajar matematika siswa di Sekolah Dasar Negeri 01 Nanga Kantuk Tahun Pelajaran 2018/2019. Populasi penelitian adalah seluruh siswa di SDN 01 Nanga Kantuk sebanyak 121 orang dan yang dijadikan sampel sebanyak 55 orang menggunakan teknik Sampling Purposive, terdiri dari kelas IV, V dan VI. Pendekatan pada penelitian ini kuantitatif dengan metode analisis faktor dan analisis deskriptif, sedangkan bentuk penelitian ini adalah analisis faktor eksploratori. Hasil analisis faktor ditemukan 5 faktor yang mengelompok yang mempengaruhi kesulitan belajar yang diberi nama faktor minat dengan persentase variance 28.997%, faktor guru dengan persentase 14.386%, faktor kebiasaan belajar dengan persentase 9.860%, faktor lingkungan keluarga dengan persentase 9.860% dan faktor suasana rumah dengan persentase varians 7.290%. Sedangkan faktor yang paling dominan mempengaruhi kesulitan belajar yaitu faktor minat dengan persentase varians 28,997%.
Minat baca dan keterampilan metakognitif pada pembelajaran biologi melalui model pembelajaran remap think pair share
Authors: Setiawan Deny , Zubaidah Siti , Mahanal Susriyati
Published: June 2020

Keterampilan metakognitif dan minat baca akan dapat diberdayakan melalui model pembelajaran yang sesuai. Penelitian bertujuan untuk mengetahui 1) peningkatan minat baca dan keterampilan metakognitif melalui penerapan model pembelajaran Remap Think Pair Share, dan 2) hubungan antara minat baca terhadap keterampilan metakognitif pada pembelajaran Biologi berbasis Remap TPS. Penelitian ini merupakan penelitian pra-eksperimental dengan menggunakan metode deskriptif-korelasional. Data minat baca diperoleh dengan instrumen angket minat baca, sedangkan keterampilan metakognitif diukur dengan menggunakan rubrik yang terintegrasi tes esai. Hasil penelitian menunjukkan bahwa: 1) adanya peningkatan sebesar 1,80% pada aspek minat baca dan keterampilan metakognitif sebesar 122,19% melalui penerapan Remap TPS; 2) tidak terdapat hubungan antara minat baca dan keterampilan metakognitif pada Remap TPS. Oleh karena itu, model pembelajaran Remap TPS dapat digunakan sebagai alternatif dalam meningkatkan minat baca dan keterampilan metakognitif jika dilakukan secara berkelanjutan.Kata kunci: Minat baca, keterampilan metakognitif, remap TPS Reading interest and metacognitive skills on biology course through remap think pair share model. Metacognitive skills and reading interest could be empowered through spesific learning model. This current study aims to investigate 1) the improvement of reading interest and metacognitive skills during the process of learning in Remap Think Pair Share learning models, and 2) the relationship between reading interest to metacognitive skills through Remap TPS learning models. This research was a pra-experimental study using descriptive-correlational method. Reading interest data was obtained by reading interest questionnaire instruments, while metacognitive skills were used by using an integrated rubric essay test. The results showed that: 1) the improvement by 1.80% for students reading interest and metacognitive skills by 122.19% through Remap TPS; 2) there was no relationship between reading interest and metacognitive skills in TPS Remap. Therefore, the Remap TPS learning model can be used as an alternative in empower reading interest and metacognitive skills when used sustainably.Keywords: Reading interest, metacognitive skills, remap TPS
PENGARUH KUALITAS PELAYANAN KOPERASI TERHADAP KEPUASAN ANGGOTA KOPERASI SIMPAN PINJAM (KSP) BHAKTI LESTARI KECAMATAN SUNGAI TEBELIAN
Authors: Khuswati Enny , Relita Dessy Triana
Published: June 2020

Abstract:This study aims to determine how the influence of service quality on member satisfaction. This research is quantitative research. The population in this study were 503 members of the Bhakti Lestari Savings and Credit Cooperative who addressed the Merarai Satu Village, Sungai Tebelian District, Sintang Regency. The number of samples in this study were 80 respondents, the sampling method  Used was Simple Random Sampling. Data analysis was first carried out by looking for validity and reliability, contribution tests, and classic assumption tests. The results showed that the quality of service affects the satisfaction of members of the Cooperative Bhakti Lestari with the results of the t test, obtained a t count of 8.774 is greater than (>) t table of 1.990 and the value of Sig. 0,000 <0.05.Keywords: Service Quality, Member SatisfactionAbstrak: Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh kualitas pelayanan terhadap kepuasan anggota. Penelitian ini termasuk jenis penelitian kuantitatif.Populasi pada penelitian ini adalah anggota Koperasi Simpan Pinjam (KSP) Bhakti Lestari sebanyak 503 orang yang beralamatkan di Desa Merarai Satu, Kecamatan Sungai Tebelian, Kabupaten Sintang.Jumlah sampel dalam penelitian ini sebanyak 80 responden, metode pengambilan sampel yang digunakan adalah Simple Random Sampling.Analisis data terlebih dahulu dilakukan dengan mencari validitas dan reliabilitas, uji kontribusi, serta uji asumsi klasik. Hasil penelitian menunjukkan bahwa kualitas pelayanan berpengaruh terhadap kepuasan anggota Koperasi Bhakti Lestari dengan hasil uji t, diperoleh nilai thitung 8,774 lebih besar dari (>) ttabel 1,990dan nilai Sig. 0,000 < 0,05Kata Kunci: Kualitas Pelayanan, Kepuasan Anggota
WARISAN KEARIFAN LOKAL DALAM TRADISI NAIK JURONG PADA SUKU DAYAK MUALANG DIKABUPATEN SEKADAU
Authors: Hartini Agnesia , Fusnika Fusnika
Published: June 2020

Kearifan lokal dan warisan budaya yang berkembang di masyarakat pedesaan saat ini adalah merupakan hasil dari kebiasaan masyarakat setempat atau kebudayaan masyarakat sebagai bentuk adaptasi terhadap alam dan lingkungan tempat tinggalnya. Penelitian ini bertujuan memperoleh informasi tentang upaya pelestarian warisan kearifan lokal dalam tradisi Naik Jurong pada suku dayak Mualang di Kabupaten Sekadau. Penelitian ini peneliti menggunakan metode kualitatif dengan bentuk penelitian deskriptif dalam penelitian ini peneliti menggunakan pendekatan kualitatif. Subjek dalam penelitian ini yaitu Ketua Adat, tokoh pemuda, dan masyarakat suku dayak Mualang. Teknik pengumpulan data dilakukan dengan observasi langsung, wawancara dan dokumentasi. Wujud warisan kearifan lokal dalam tradisi Naik Jurong pada masyarakat suku Dayak Mualang merupakan sebuah upaya pelestarian  dan pemeliharaan budaya Naik Jurong yang sampai sekarang masih di lestarikan setiap tahun setelah panen berakhir.  Adapun  unsur yang terkandung dalam tradisi Naik Jurong adalah terdapat aspek religius merupakan wujud syukur berterima kasih  kepada Tuhan atas hasil panen yang diperoleh, aspek kehidupan kekeluargaan solidaritas serta pemersatu masyarakat suku dayak Mualang sampai sekarang. Kata kunci: Kearifan Lokal, Naik Jurong, Dayak Mualang
Kebijakan Internal Madrasah Dalam Meningkatkan Mutu Pendidikan Di MI Nurul Ummah Kotagede Yogyakarta
Authors: Alfiansyah Muhammad , Assingkily Muhammad Shaleh , Prastowo Andi
Published: June 2020

Abstract

This research describes several management of MI Nurul Ummah in order to improve the quality of education in the school, the type of research in this paper is descriptive qualitative. Data collection techniques used by interview and also with various sources both from relevant books and journals. From the results of the writing, it is known that there are some policies implemented by MI Nurul Ummah management (1) Assisting the reading of Asmaul Husna, intends to educate students characters to love Allah through Asmaul Husna, (2) The implementation of Full Day School, the application of this policy is expected to make it easier to supervise students in the school, (3) Dhuha prayer in congregation, get children to pray in congregation and a good character building, (4) The training of teachers to upgrade teachers knowledge in order to produce a good quality of education. While that which is the inhibiting factors of the policy namely internal factors (Funds, Teachers, Students) external factors (Parents of Students, Society)
PEMIKIRAN FAZLUR RAHMAN DALAM KAJIAN QUR’AN-HADIS (TELAAH KRITIS)
Authors: Rohman Anas
Published: June 2020

Abstract

Fazlur Rahman is one of the new innovators in Islam that had a great influence in the 20th century, especially in Pakistan, Malaysia, Indonesia, and other countries (Islamic countries), and Chicago America (western countries) who had various thoughts related to problem. He succeeded in thinking critically both Islam and Western traditions. He succeeded in developing methods that could provide alternative solutions to contemporary Muslims. Rahman's thoughts contributed a lot to the development of Islamic studies, especially in the study of the Qur'an-Hadith. the historical-sociological approach above will create a new, dynamic, and creative discourse so that the moral ideal of the Prophet's sunnah. can be realized progressively in a variety of social phenomena and problems, so that the hadith is no longer static but becomes a living sunnah.

Keywords: Thought, Fazlur Rahman, Qur'anic Hadith.

Abstrak

Fazlur Rahman adalah salah satu inovator baru dalam Islam yang memiliki pengaruh besar di abad 20, terutama di Pakistan, Malaysia, Indonesia, dan negara-negara lain (negara-negara Islam), dan Chicago America (negara barat) yang memiliki berbagai pemikiran terkait dengan masalah. Ia sukses berpikir kritis baik Islam maupun tradisi Barat. Ia berhasil mengembangkan metode yang bisa memberikan solusi alternatif terhadap Muslim kontemporer. Pemikiran Rahman banyak memberikan sumbangsih terhadap perkembangan kajian Islam, khususnya dalam kajian Qur’an-Hadis. pendekatan historis-sosiologis di atas akan menciptakan wacana yang baru, dinamis, dan kreatif sehingga ideal moral dari sunnah Nabi Saw. dapat direalisasikan secara progresif di dalam aneka ragam fenomena dan permasalahan sosial, sehingga hadis tidak lagi statis melainkan menjadi sunnah yang hidup.

Kata kunci : Pemikiran, Fazlur Rahman, Qur’an Hadis
Description of Escherichia Coli In Well Water
Authors: Fahrurriza Febry Risdhityatama , Surati Surati
Published: June 2020

Most of the wells are still used as a source of drinking water. This well is widely used in the village of Rejosari Grobogan. Regulation of the Minister of Health No. 492 of 2010 concerning the Requirements for Quality of Drinking Water is 0 per 100 ml of sample. The existence of Escherichia coli in water sources affects water quality which has an impact on consumer health, so it is necessary to know whether the quality of water sources from dug wells meets drinking water standards. To find out whether Escherichia coli bacteria were present in the well water of Rejosari Grobogan Village. The research conducted included a type of quantitative research with a descriptive design. The sample used was 11 samples. The results of the examination showed that there was an Escherichia coli bacterium in the well water of Rejosari Grobogan Village with an average number of bacteria 1.8 per 100 ml of sample. Research on samples was carried out using the Most methodProbable Number (MPN). Rejosari Grobogan village water wells were found to contain Escherichia coli bacteria and not meet water quality standards in accordance with Minister of Health Regulation No. 32 of 2017.
Overview of Ureum and Creatinine Levels in Hemodialysis Patients with Chronic Kidney Disease
Authors: Afriansya Roni Roni , Sofyanita Eko Naning , Suwarsi Suwarsi
Published: June 2020

Chronic Kidney Disease is evident if the blood urea level is more than 200 mg/dl. Uremia causes a malfunction in almost all organ systems such as; fluid and electrolyte disorders, metabolic endocrine, neuromuscular, cardiovascular and pulmonary, skin, gastrointestinal, hematological, and immunological. Hemodialysis is an attempt to reduce the symptoms of uremia so that the patient's clinical condition can also improve. The purpose of this study was to determine the description of Ureum and Creatinine in CKD Patients undergoing Hemodialysis. This type of research is observational descriptive. The sample included all CKD patients undergoing hemodialysis at the Ir Sukarno Sukoharjo Regional Hospital in 2019 who met the inclusion criteria, so as many as 83 samples were obtained. The type of data is secondary data obtained from medical records. The results showed that most patients were in the 40-60 years age group of 72% and the majority of the male sex were 51 patients (61%). Urea and creatinine appearance in patients undergoing hemodialysis has increased very high. In 83 patients with CKD increased serum creatinine levels ( 100%) with a mean creatinine level in men of 11.80 mg / dL and women of 9.73 mg / dL and an increase in ureum levels with a mean of 167 men, 09 mg / dL and women of 164.39 mg / dL. This study concludes that all patients with CKD have increased levels of urea and creatinine by more than 100%.
A review of Kurozu, amber rice vinegar made in pottery jars
Authors: Shibayama Yoshihiko , Kanouchi Hiroaki , Fujii Akira , Nagano Masanobu
Published: June 2020

Brewed rice vinegar, Kurozu, is a traditional Japanese vinegar with a dark amber color. Kurozu is produced in a regional area of Japan using traditional techniques and made inside handcrafted pottery jars. Kurozu is used as both a seasoning and a healthcare supplement. In vitro and in vivo investigations of ingredients in Kurozu have been carried out. Studies of the functional aspects of Kurozu began in the 1980s, and the health promoting and disease preventing effects of Kurozu have since been elucidated. It was reported that Kurozu improved the symptoms of hypertension, allergies, hypercholesterolemia, enhanced carbohydrate metabolism, and inhibited tumor growth. Kurozu-Moromi is an insoluble product created from the fermentation of Kurozu. Kurozu-Moromi also shows valuable properties, including improvement in dyslipidemia, prevention of hyperglycemia, antitumor effect, and antiallergic activity.Keywords: Amber color, Brewed vinegar, Functionality, Moromi, Pottery jars
Dementia and COVID-19 Lockdown: More Than a Double Blow for Patients and Caregivers
Authors: Migliaccio Raffaella , Bouzigues Arabella
Published: June 2020

In dementia research and in clinical practice, the COVID-19 pandemic represents an important challenge, not only for neurological staff and researchers, but above all for patients and their caregivers. It is important that the medical staff demonstrate flexibility, open-mindedness, and humanity when following patients and caregivers. It seems inevitable that caregivers will pay the highest price during this crisis.
Sector categorization using gradient boosted trees trained on fundamental firm data
Authors: Fang Ming , Kuo Lilian , Shih Frank , Taylor Stephen
Published: June 2020

We examine to what extent the GICS sector categorization of equity securities may be systematically reconstructed from historical quarterly firm fundamental data using gradient boosted tree classification. Model complexity and performance tradeoffs are examined and relative feature importance is described. Potential extensions are outlined including ideas to improve feature engineering, validating internal consistency and integrating additional data sources to further improve classification accuracy.
Flavonoids as an Intervention for Alzheimer’s Disease: Progress and Hurdles Towards Defining a Mechanism of Action1
Authors: Hole Katriona L. , Williams Robert J.
Published: June 2020

Attempts to develop a disease modifying intervention for Alzheimer’s disease (AD) through targeting amyloid β (Aβ) have so far been unsuccessful. There is, therefore, a need for novel therapeutics against alternative targets coupled with approaches which may be suitable for early and sustained use likely required for AD prevention. Numerous in vitro and in vivo studies have shown that flavonoids can act within processes and pathways relevant to AD, such as Aβ and tau pathology, increases in BDNF, inflammation, oxidative stress and neurogenesis. However, the therapeutic development of flavonoids has been hindered by an ongoing lack of clear mechanistic data that fully takes into consideration metabolism and bioavailability of flavonoids in vivo. With a focus on studies that incorporate these considerations into their experimental design, this review will evaluate the evidence for developing specific flavonoids as therapeutics for AD. Given the current lack of success of anti-Aβ targeting therapeutics, particular attention will be given to flavonoid-mediated regulation of tau phosphorylation and aggregation, where there is a comparable lack of study. Reflecting on this evidence, the obstacles that prevent therapeutic development of flavonoids will be examined. Finally, the significance of recent advances in flavonoid metabolomics, modifications and influence of the microbiome on the therapeutic capacity of flavonoids in AD are explored. By highlighting the potential of flavonoids to target multiple aspects of AD pathology, as well as considering the hurdles, this review aims to promote the efficient and effective identification of flavonoid-based approaches that have potential as therapeutic interventions for AD.
Amyloid-β Protein Precursor Regulates Depolarization-Induced Calcium-Mediated Synaptic Signaling in Brain Slices
Authors: Chatzistavraki Maria , Papazafiri Panagiota , Efthimiopoulos Spiros
Published: June 2020

Background:

Coordinated calcium influx upon neuronal depolarization activates pathways that phosphorylate CaMKII, ERKs, and the transcription factor CREB and, therefore, expression of pro-survival and neuroprotective genes. Recent evidence indicates that amyloid-β protein precursor (AβPP) is trafficked to synapses and promotes their formation. At the synapse, AβPP interacts with synaptic proteins involved in vesicle exocytosis and affects calcium channel function.

Objective:

Herein, we examined the role of AβPP in depolarization-induced calcium-mediated signaling using acute cerebral slices from wild-type C57bl/6 mice and AβPP–/– C57bl/6 mice.

Methods:

Depolarization of acute cerebral slices from wild-type C57bl/6 and AβPP–/– C57bl/6 mice was used to induce synaptic signaling. Protein levels were examined by western blot and calcium dynamics were assessed using primary neuronal cultures.

Results:

In the absence of AβPP, decreased pCaMKII and pERKs levels were observed. This decrease was sensitive to the inhibition of N- and P/Q-type Voltage Gated Calcium Channels (N- and P/Q-VGCCs) by ω-conotoxin GVIA and ω-conotoxin MVIIC, respectively, but not to inhibition of L-type VGCCs by nifedipine. However, the absence of AβPP did not result in a statistically significant decrease of pCREB, which is a known substrate of pERKs. Finally, using calcium imaging, we found that down regulation of AβPP in cortical neurons results in a decreased response to depolarization and altered kinetics of calcium response.

Conclusion:

AβPP regulates synaptic activity-mediated neuronal signaling by affecting N- and P/Q-VGCCs.
Clinical and Pathological Phenotypes of LRP10 Variant Carriers with Dementia
Authors: Vergouw Leonie J. M. , Geut Hanneke , Breedveld Guido , Kuipers Demy J. S. , Quadri Marialuisa ,   Netherlands Brain Bank, Rozemuller Annemieke J. M. , van Swieten John C. , de Jong Frank Jan , van de Berg Wilma D. J. , Bonifati Vincenzo
Published: June 2020

Background:

Rare variants in the low-density lipoprotein receptor related protein 10 gene ( LRP10) have recently been implicated in the etiology of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).

Objective:

We searched for LRP10 variants in a new series of brain donors with dementia and Lewy pathology (LP) at autopsy, or dementia and parkinsonism without LP but with various other neurodegenerative pathologies.

Methods:

Sanger sequencing of LRP10 was performed in 233 donors collected by the Netherlands Brain Bank.

Results:

Rare, possibly pathogenic heterozygous LRP10 variants were present in three patients: p.Gly453Ser in a patient with mixed Alzheimer’s disease (AD)/Lewy body disease (LBD), p.Arg151Cys in a DLB patient, and p.Gly326Asp in an AD patient without LP. All three patients had a positive family history for dementia or PD.

Conclusion:

Rare LRP10 variants are present in some patients with dementia and different brain pathologies including DLB, mixed AD/LBD, and AD. These findings suggest a role for LRP10 across a broad neurodegenerative spectrum.
Dementia Research Productivity and Associations with Socioeconomic Factors and Burden of Disease in Southeast Asia
Authors: Sy Marie Charmaine C. , Espiritu Adrian I. , Sy Matthew Samuel C. , Jamora Roland Dominic G. , Anlacan Veeda Michelle M.
Published: June 2020

Background:

Scientific output in Southeast Asia (SEA) on the topic of dementia is postulated to be low in quality and quantity. It is also speculated that certain socioeconomic variables and measures of disease burden for dementia may play a significant role in driving the research output of a particular country.

Objective:

This study aimed to determine the research impact of published journal articles on dementia in SEA and its association with country-level socioeconomic factors and measures of disease burden for dementia.

Methods:

A systematic search was conducted using electronic healthcare databases. We included articles published on dementia until August 2019 with at least 1 author affiliated with any SEA institution. We obtained bibliometric indices, relevant socioeconomic factors, and measures of disease burden for dementia from published sources.

Results:

One thousand six articles fulfilled the inclusion criteria. The majority of publications were related to Alzheimer’s disease ( n = 775, 77.0%). Singapore contributed the highest number of publications ( n = 457, 45.4%). Gross domestic product (GDP) per capita, % GDP for research and development, and total neurologists significantly correlated with several bibliometric indices. On the other hand, the measures of disease burden for dementia in SEA countries were not significantly associated with research productivity.

Conclusion:

Research productivity in SEA on dementia has substantially increased in recent years. Augmenting GDP per capita and expanding the apportionment of resources to research and development (R&D) may have a significant role in the advancement of dementia research in SEA.
The association between protein consumption from animal and plant sources with psychological distress in older people in the Mediterranean region
Authors: D’Cunha Nathan M. , Foscolou Alexandra , Tyrovolas Stefanos , Chrysohoou Christina , Rallidis Loukianos , Polychronopoulos Evangelos , Matalas Antonia-Leda , Sidossis Labros S. , Naumovski Nenad , Panagiotakos Demosthenes B.
Published: June 2020

BACKGROUND:

The potential for diet to prevent and treat mental health conditions is an exciting area of investigation; however, the impact of different protein sources on mental health outcomes is unclear.

OBJECTIVE:

To evaluate the association between dietary protein intake and psychological distress, in people aged >50 years of age, living in Greece.

METHODS:

A combined data set of older people living in the Athens metropolitan area and 20 Greek islands, from the ATTICA ( n = 1,128) and MEDIS ( n = 2,221) population-based cross-sectional studies was developed. Anthropometric, clinical and socio-demographic and lifestyle characteristics, and protein consumption (total, animal, plant) consumed based on validated FFQ, were derived through standard procedures and questionnaires. “Psychological distress” (PDS) was assessed as a combined variable representing symptoms of depression and anxiety using Item Response Theory methodology and fitting a Graded Response Model.

RESULTS:

Animal protein, but not plant protein intake, was associated with higher PDS following adjustment for age, sex, education level, Mediterranean diet adherence and physical activity ( b±SE: 0.399±0.090, p = 0.003). Following analysis by Mediterranean diet adherence level, among low adherers, animal protein intake was positively associated with PDS ( b±SE: 1.119±0.174, p = 0.003), and no associations were observed in moderate or high adherence groupsin regards to plant protein intake and PDS.

CONCLUSIONS:

Animal protein intake is associated with PDS, suggesting a bi-directional relationship, which may be influenced by Mediterranean diet adherence.
Quercetin supplementation attenuates muscle wasting in cancer-associated cachexia in mice
Authors: Levolger Stef , van den Engel Sandra , Ambagtsheer Gisela , IJzermans Jan N.M. , de Bruin Ron W.F.
Published: June 2020

BACKGROUND:

Quercetin is a flavonoid with reported antioxidant, anti-inflammatory and anti-aging effects, and may limit muscle wasting in cancer cachexia.

OBJECTIVE:

To investigate the effect of quercetin on muscle wasting in the murine C26 cancer-cachexia model and assess the feasibility of non-invasive micro-CT analysis of skeletal muscle.

MATERIALS AND METHODS:

Custom CRM(P) diets supplemented with 250 mg/kg quercetin (Q) were obtained. Thirty CD2F1 mice were equally randomized to non-tumor-bearing (NTB), C26 tumor-bearing (TB), TB + Q. All groups started their allocated diet and underwent hindlimb micro-CT. Bodyweight, food intake, and grip-strength were recorded periodically. After 21 days, repeat micro-CT was performed. Gastrocnemius (GCM) and tibialis anterior (TA) muscles were resected. mRNA expression of MuRF1, Atrogin-1, myogenin, and MyoD was determined.

RESULTS:

NTB and TB + Q gained 9.4% and 5.3% bodyweight respectively, TB lost 3.9%. Hind limb skeletal muscle volume remained stable for NTB and TB + Q, whereas TB decreased from 242.0 mm3 to 212.8 mm3. Mean GCM muscle weight was 175.2 mg (NTB), 171.3 mg (TB + Q) versus 125.5 mg (TB). A tendency towards decreased expression of atrogin-1 and MuRF1 was observed in TB + Q.

CONCLUSION:

Dietary quercetin supplementation limits bodyweight loss and muscle wasting in the C26-cancer-associated cachexia model.
大数据背景下矿山测绘地理信息检测探析
Authors: 韩 棚举
Published: June 2020

矿山研究和测绘的地理信息是国家资源的重要信息,在矿产资源开发,工业发展,技术发展乃至国防建设方面都具有重要作用。信息技术为充分利用矿山研究和测绘提供了便利的平台,在此基础上,进一步促进大数据在地理信息测绘中的应用,本文对此问题进行基本分析和讨论,以供参考。
土地利用变化对区域碳汇的影响综述
Authors: 陈 媛
Published: June 2020

加剧全球变暖的主要原因是二氧化碳在大气中的浓度上升。减少大气中二氧化碳的浓度,除了碳减排,还有增加碳汇。陆地碳汇动力主要来源于植被,不同的植被类型碳汇差异较大,而土地利用变化影响不同植被类型构成,从而影响区域碳汇能力。国内外已经有众多学者对土地利用变化对区域碳汇的影响进行总结,本篇文章在此基础上围绕不同植被类型对陆地生态系统的碳循环问题展开,对全球及区域范围内土地利用变化对林地、草地以及耕地三种陆地碳汇进行综合叙述。过度农垦及建设用地扩张、森林面积缩减并大部分向草地和耕地转化,导致碳汇量减少,在具体的数据分析中,温带地区土地利用变化带来的碳汇影响要低于地带地区。
无人机航摄技术在大比例尺地形图测绘中的应用
Authors: 邵 晴晴
Published: June 2020

无人机航摄技术具有良好的灵活性,而且经济便捷,逐步取代了传统航空摄影测量。被广泛应用在大比例尺地形图测绘中。基于此,本文结合理论实践,在简要阐述无人机航摄系统结构组成的机场上,分析了无人机航摄技术的特点,并提出此项技术在大比例尺地形图测绘中的具体应用,希望对我国地形图测绘事业稳健发展有一定参考。
测绘工程测量中无人机遥感技术的运用分析
Authors: 屠 金龙
Published: June 2020

本文将对无人机遥感技术的概述及实施效果进行简要的分析阐述,并以此为基础,指出测绘工程测量中无人机遥感技术的运用,以期能够为业内人士提供理论参考。
液体静力水准和引张线法在大坝变形监测中的应用
Authors: 李 富威 , 黄 初
Published: June 2020

使用简易的液体静力水准装置和引张线装置对直线型大坝实施变形观测,结合高精度的水准仪和全站仪实施同步变形观测,通过对比两种测量方法的结果和精度,论述简易的静力水准装置和引张线装置在大坝变形观测中,在保证精度符合规范的前提下更经济更可靠更易操作。
Quantification of edema in edematous severe acute malnutrition children aged 6 months to 5 years
Authors: Suman Rameshwar L , Singla Sanjay , Chaudhry Chakshu , Ninama Rameshwar , Sharma Bharat Lal , Goyal Suresh
Published: June 2020

Background: Malnutrition is rampant in India, and edematous severe acute malnutrition (SAM) is associated with high morbidity and mortality. Clinical grading of edema in these children is known, but still, no quantification has been described. Objective: The objective of this study was to quantify the edema in children with edematous SAM (E-SAM). Materials and Methods: This prospective study was conducted over a period of 1 year in 2016 at a malnutrition treatment center of tertiary hospital attached to a medical college. 50 children were selected with E-SAM between 6 months and 5 years of age. The sick children, needing intensive care unit care and having edema other than nutritional cause, were excluded from the study. These children were examined daily for any change in the status of edema by comparing the change in the weight, which was taken using electronic weighing scale. The weight at which child has no edema and no fall in weight for 2 consecutive days was defined as dry weight of the child. All the children were evaluated regarding the onset of loss of edema, days taken for complete disappearance of edema, weight loss per day, mean loss of weight, etc. Results: Of 50 children with E-SAM, 28 were male and 22 were females. Mean age of children was 16.5±11.04 months. The admitted children had +2 edema (26%), followed by +3 edema (17%), while only 7 (14%) children had +1 edema. The mean age of moderate-to-severe edematous children was 13 months. These children started losing edema by day 3 (3.22±0.9) and the mean number of days for complete disappearance of edema was 10.02±2.8 days. The mean percent weight loss was 1% per day and did not vary with different grades of edema (p>0.5). The percentage loss of total weight was maximum for children with +3 edema being 13%, followed by 10% in +2, and 5% in +1 edema which was statistically significant (p=0.004). Conclusions: E-SAM children have grade +1, +2, and +3 edema which are equivalent to 5%, 10%, and >10% over to their actual weight, respectively, and younger children are more susceptible to moderate-to-severe edema.
Study of prenatal, natal, and neonatal risk factors associated with autism
Authors: Sahana K S , Bhat Sham S , Kakunje Anil
Published: June 2020

Introduction: Autism spectrum disorder is one of the common developmental disabilities. Underlying autism etiology is most likely polygenic but environmental factors may also contribute. Obstetrical and neonatal risk factors have been considered for the development of autism. Objectives: The objectives of the study were to know the presence of antenatal, perinatal and neonatal complications in autistic children. Materials and Methods: Children who were diagnosed with autism were included in the study. Visits were made to the special school for the collection of data with prior consent, and birth details were collected from the parents. Results: A total of 54 children were included in the study. Age of the children ranged from 3 years to 17 years with the mean age of 10.93 years. 39 (72.2%) were boys and 15 (27.8 %) were girls. Advanced maternal age at delivery was noted in 24% of the cases. Antenatal risk factors were seen in 24% of cases and natal risk factors in 20% of the cases. 17% had birth asphyxia. Neonatal intensive care unit admission was noted in 20% of cases, neonatal seizures in 5.6%, respiratory distress in 9.3%, and low birth weight in 17% of cases. 60% of them were first born. Overall, the presence of antenatal, natal, and postnatal risk factors were noted in 57% autism cases. Conclusion: In children with autism, there is increased prevalence of obstetric and neonatal risk factors. These variables should be examined in future for precise assessments of exposures.
Socioeconomic determinants of breastfeeding practices in South India - A hospital-based cross-sectional study
Authors: Naaraayan Sridevi A , Priyadharishini Dorairaj , Geetha R , Vengatesan A
Published: June 2020

Background: Breastfeeding is an unparalleled universally recommended intervention for the promotion of health and nutrition of children and reduction of mortality. In spite of the WHO recommendations and baby-friendly hospital initiative, breastfeeding practices are inappropriate due to maternal, infant, socioeconomic, and cultural factors. Objective: The objective of this study was to determine the socioeconomic factors associated with inappropriate breastfeeding practices. Secondary objective was to determine the knowledge level of mothers on ideal breastfeeding recommendations. Materials and Methods: This cross-sectional study was conducted in pediatric wards of a tertiary care teaching institution from January 2017 to July 2017. Mothers having children aged 7–60 months were included in the study. A sample size of one thousand was planned. After obtaining informed consent from mother, detailed feeding history including the timing of initiation of breastfeeding following childbirth, duration of exclusive breastfeeding, and age at which breastfeeding was discontinued was noted. Possible determinants considered were gender of the child, place of residence, maternal age, maternal education, maternal employment, number of children at home, type of family, whether mother was counseled during antenatal period, mode of delivery, and hospitalization in newborn period. Knowledge of mother on breastfeeding was probed and the response recorded. Univariate analysis followed by regression was performed to determine the significant factors. Results: 59% (95% confidence interval 55.9–62.1) of mothers initiated breastfeeding within 1 h of childbirth. 70.2% (95% CI - 67.3–73) exclusively breastfed their babies for 6 months and above. 43.6% (95% CI - 39.2–48.1) of mothers with children of age 25–60 months breastfed their babies up to 2 years and beyond. On univariate analysis, female gender, maternal employment, operative delivery, and hospitalization in the newborn period were identified as risk factors for inappropriate breastfeeding practices, which were confirmed by regression. Overall, only 26.6% (95% CI - 23.9–29.5) of mothers had appropriate knowledge about ideal breastfeeding recommendations. Conclusion: Female gender, maternal employment, operative delivery, and hospitalization in newborn period are significant independent risk factors for inappropriate breastfeeding practices. Only a quarter of mothers had adequate knowledge of breastfeeding recommendations.
Infatuation and love of an adolescent girl: Dynamics of parent child relationship
Authors: Janardhana N , Manjula B
Published: June 2020

Background: Increased interest in romantic relationship (RR) is central to adolescents’ lives. RR has a significant influence on the emotional well-being of the adolescents and their future life. Objective: The present study aims at understanding the issues and concerns of adolescent girls in RR who come under care and protection issue. Methods: The study adopts a retrospective exploratory research design and analyzed the case reports maintained by psychiatric social workers. Reports elicit the information about the RR, marriage with the romantic partner, reason for run away with the marital partner, etc. Results: Majority of the adolescents run away with their romantic partner to get married and more than three-fourth of the adolescent girls believed that having sexual intercourse with their romantic partner would get their marriage approval and felt that marriage gave them sanction for the sexual relationship. Adolescents were worried about parent’s rejection of their romantic partner and had guilt feeling that they were not able to meet the expectations of parents nor they were able to fulfill the dreams of their parents. Most of the adolescents were also aware that their romantic involvement has been one of the reasons for academic decline; some have to drop out from the schools. Conclusion: It is important to understand the issues of adolescent girls in RR so that it would help us in designing interventions to facilitate developmental needs and for the healthy transition to adulthood.