bluuebunny/crossref_metadata_2025 huggingface dataset:
Network education platform in flipped classroom based on improved cloud computing and support vector machine
Authors: Jing Leng , Bo Zhu , Tian Qingxiang , Xu Wei , Shi Jiaoxue
Published: June 2020

The current online education platform has gradually replaced the traditional teaching mode and has become an efficient teaching method. Flipping classroom is a new teaching mode under the background of the rapid development of information technology. It is also an important way of multimedia network teaching. However, compared with the traditional teaching mode, teachers in the online teaching platform cannot judge the students’ psychological activities through the students’ state of mind, and they can grasp the students’ learning status through the teaching process. Based on this, based on the cloud computing platform, this study improves the data transmission effect and improves the algorithm according to the learning process of the online education platform. Moreover, this study combines support vector machine to construct a student state recognition system suitable for online education platform and conducts algorithm performance analysis through experiments. In addition, this study uses MKmeans algorithm, Kmeans algorithm and improved Kmeans algorithm, that is, K-mediods and Xmeans algorithm to compare the pre-processed final data sets. The research results show that the proposed algorithm is suitable for network teaching platform and has certain practical effects.
The graph model for conflict resolution with consensus fuzzy preferences and its application to environmental sustainable development
Authors: Wu Nannan , Xu Yejun , Xu Lizhong , Wang Huimin
Published: June 2020

Conflict of environmental sustainable development as a common phenomenon can be seen everywhere in life. To capture consensus problems of decision makers (DMs) in conflict, a consensus and non-consensus fuzzy preference relation (FPR) matrix is proposed to the framework of the Graph Model for Conflict Resolution (GMCR). Concentrating on the case of two DMs within GMCR paradigm, four standard fuzzy solution concepts are developed into eight fuzzy stability definitions which can fully represent DMs’ behavior characteristics of win-win and self-interested. To demonstrate how the novel GMCR methodology proposed in this paper can be conveniently utilized in practice, it is then applied to an environmental sustainable development conflict with two DMs. The results show that the general fuzzy equilibrium solutions are the intersection of consensus fuzzy equilibrium and non-consensus fuzzy equilibrium. Therefore, the GMCR technique considering DMs’ consensus can effectively predict the various possible solutions of conflict development under different DMs’ behavior preferences and provide new insights for analysts into a conflict.
AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives
Authors: Turski Waldemar A. , Wnorowski Artur , Turski Gabrielle N. , Turski Christopher A. , Turski Lechoslaw
Published: June 2020

Covid-19 is the acute illness caused by SARS-CoV-2 with initial clinical symptoms such as cough, fever, malaise, headache, and anosmia. After entry into cells, corona viruses (CoV) activate aryl hydrocarbon receptors (AhRs) by an indoleamine 2,3-dioxygenase (IDO1)-independent mechanism, bypassing the IDO1-kynurenine-AhR pathway. The IDO1-kynurenine-AhR signaling pathway is used by multiple viral, microbial and parasitic pathogens to activate AhRs and to establish infections. AhRs enhance their own activity through an IDO1-AhR-IDO1 positive feedback loop prolonging activation induced by pathogens. Direct activation of AhRs by CoV induces immediate and simultaneous up-regulation of diverse AhR-dependent downstream effectors, and this, in turn, results in a “Systemic AhR Activation Syndrome” (SAAS) consisting of inflammation, thromboembolism, and fibrosis, culminating in multiple organ injuries, and death. Activation of AhRs by CoV may lead to diverse sets of phenotypic disease pictures depending on time after infection, overall state of health, hormonal balance, age, gender, comorbidities, but also diet and environmental factors modulating AhRs. We hypothesize that elimination of factors known to up-regulate AhRs, or implementation of measures known to down-regulate AhRs, should decrease severity of infection. Although therapies selectively down-regulating both AhR and IDO1 are currently lacking, medications in clinical use such as dexamethasone may down-regulate both AhR and IDO1 genes, as calcitriol/vitamin D3 may down-regulate the AhR gene, and tocopherol/vitamin E may down-regulate the IDO1 gene. Supplementation of calcitriol should therefore be subjected to epidemiological studies and tested in prospective trials for prevention of CoV infections, as should tocopherol, whereas dexamethasone could be tried in interventional trials. Because lack of physical exercise activates AhRs via the IDO1-kynurenine-AhR signaling pathway increasing risk of infection, physical exercise should be encouraged during quarantines and stay-at-home orders during pandemic outbreaks. Understanding which factors affect gene expression of both AhR and IDO1 may help in designing therapies to prevent and treat humans suffering from Covid-19.
La encíclica "Laborem exercens" y la democratización de la economía
Authors: Redacción Consejo de
Published: June 2020

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La democracia económica como utopía concreta
Authors: Büchele Herwig
Published: June 2020

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El petróleo no es la causa de la crisis
Authors: Martínez Galdeano Fernando
Published: June 2020

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La ayuda económica al obrero en un círculo católico
Authors: La Parra López Emilio
Published: June 2020

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Norte-Sur ¿un dialogo imposible?
Authors: Gomez Camacho Francisco
Published: June 2020

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Agricultura y nuevo orden económico internacional
Authors: Romero Rodríguez José Juan
Published: June 2020

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El socialismo en la "Laborem Exercens"
Authors: Camacho Laraña Ildefonso
Published: June 2020

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Propiedad privada y salario justo
Authors: Higuera Gonzalo
Published: June 2020

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El desempleo en "Laborem Exercens"
Authors: Ortega Victorino
Published: June 2020

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Espiritualidad del trabajo
Authors: Iturrioz Jesús
Published: June 2020

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Perspectivas del empleo
Authors: García de Leaniz Pedro
Published: June 2020

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El paro en Aragón
Authors: Alemany Jesús María
Published: June 2020

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El desempleo en el País Vasco
Authors: Irigoien Josu
Published: June 2020

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La iglesia ante el paro
Authors: Salinas Ramos Francisco
Published: June 2020

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Entidad convocante y gestación del congreso
Authors: De Formación Social de Vigo Comité de Dirección De la Escuela
Published: June 2020

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Cultura popular hoy día
Authors: Del Río Martín Enrique
Published: June 2020

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Sindicalismo: Masas, Burocracia y Militancia
Authors: Gomez Del Castillo Julian
Published: June 2020

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Formación ciudadana y autonomías
Authors: Rojo Salgado Argimiro
Published: June 2020

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La sociedad civil y la Convención de los Derechos de los Trabajadores Migratorios y sus Familias: alternativas ante su débil consenso
Authors: González Iza Daniela
Published: June 2020

El desarrollo de normas internacionales de derechos humanos y de sus instituciones ha permitido cierto protagonismo de las organizaciones de la sociedad civil. El objetivo de este trabajo de investigación es analizar los alcances y límites de la sociedad civil en su interacción con el Comité para los Trabajadores Migratorios de las Naciones Unidas, tomando en cuenta que su instrumento normativo (la Convención de los Derechos de los Trabajadores Migratorios y sus Familias) es de los menos aceptados a nivel internacional. Por lo tanto, se evalúa hasta qué punto la falta de consenso internacional sobre la Convención puede representar una limitante en la relación de la sociedad civil con este Comité
La importancia de la inversión de riesgo corporativo para superar el valle de la muerte en la transferencia tecnológica universitaria
Authors: Alunni Andrea
Published: June 2020

Actualmente en un ecosistema clásico de innovación, las oficinas de transferencia tecnológica (TTOs, por sus siglas en inglés) de la universidad estarían buscando aumentar las inversiones del sector privado (i.e. Corporaciones de los varios sectores industriales tales como el farmacéutico, digital, manufacturero, etc.) para avanzar las actividades de investigación basadas en la propiedad intelectual (PI) hacia el mercado. Del otro lado, las Corporaciones también estarían buscando oportunidades de inversión en nuevas empresas (startups) que coincidan con sus actividades de estrategia corporativa basadas en la innovación. Esto parece ofrecer la combinación perfecta para una colaboración universidad–industria exitosa. Sin embargo, al observar los impulsores que motivan esta relación, es posible distinguir que las universidades y las corporaciones tienen sea diferentes perspectivas sobre temas comunes que afectan su relación. Estas diferencias se hacen evidentes, por ejemplo, cuando a un proyecto universitario de investigación se le agota la subvención del gobierno y el investigador aún no ha alcanzado obtener financiación externa de inversores privados para convertirla en una startup. Sin esta inversión externa, el recorrido de la investigación universitaria hacia el mercado para transformarse en producto o servicio social y económicamente útil, pero que aún no es comercialmente viable, puede detenerse. A esta falta de fondos en el desarrollo de un proyecto se le llama “valle de la muerte” y representa el tema central de la discusión de este capítulo.
Temozolomide in glioblastoma treatment: 15-year clinical experience and analysis of its efficacy
Authors: Glavatskyi O.Ya. , Zemskova O.V. , Khmelnytskyi H.V. , Kardash K.A. , Shuba I.M. , Stuley V.A.
Published: June 2020

Summary. Aim: To analyze retrospectively the efficacy of temozolomide (TMZ) in various treatment regimens in glioblastoma patients accounting for varying parameters of their treatment. Materials and Methods: 302 glioblastoma patients were treated at the State Institution “Romodanov Institute of Neurosurgery of the National Academy of Medical Sciences of Ukraine” from 2003 through 2017. All the patients were surgically treated. In 205 patients, the surgery was followed by adjuvant radiotherapy (RT) with concomitant TMZ (RT + TMZ group). In 97 patients, the surgery was followed by adjuvant RT only (RT group). Kaplan — Meier survival analysis with log-rank test and Cox proportional hazards regression analysis were used for comparing overall survival (OS) and recurrence-free survival (RFS) depending on the age and gender of the patients, the extent of tumor resection, the chemotherapy intensity and the type of RT. Results: In RT + TMZ group as a whole, OS median was 20.7 months vs 10.8 months in RT group (р < 0.0001). The RFS was 14.8 months vs 7.9 months, correspondingly (р < 0.0001).The survival did not depend on the age, gender or localization of the tumor. On the contrary, the intensity of CTX (the number of TMZ cycles in adjuvant mode), the extent of tumor resection, and the type of RT were among the factors affecting significantly OS and RFS. The improvement in OS and RFS with increasing number of the maintenance TMZ courses was more significant in the patients aged below 60. The use of stereotactic conformal mode for RT provides an advantage in the survival over the conventional RT in RT + TMZ group. Conclusions: The combination of concomitant and adjuvant maintenance CTX with TMZ was the most effective CTX regimen affecting positively OS and RFS.
Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells
Authors: Antonenko S.V. , Telegeev G.D.
Published: June 2020

Summary. Aim: To analyze interaction of ubiquitin specific peptidase 1 (USP1) with Bcr-Abl and to assess the relation between USP1 functional activity and Bcr-Abl expression in K562 chronic myeloid leukemia cells. Materials and Methods: The interaction between USP1 and Bcr-Abl in K562 cells was analyzed by co-immunoprecipitation, Western blot analysis, and confocal microscopy. Results: A direct interaction between Bcr-Abl oncoprotein and USP1 protein in K562 cells was established by co-immunoprecipitation. Immunofluorescence analysis and confocal microscopy revealed that Bcr-Abl/USP1 protein complex is formed in the cell nucleus. The inhibition of USP1 protein activity by ML323 reduced the level of Bcr-Abl oncoprotein in K562 cells. Conclusions: USP1 protein has been identified as a new protein partner of Bcr-Abl oncoprotein in chronic myeloid leukemia. The relationship between the functional activity of USP1 protein and the level of Bcr-Abl oncoprotein has been demonstrated, suggesting that the targeted inhibition of USP1 activity could be a challenging approach for reducing Bcr-Abl expression.
Income diversification for risk adaptation: the case of rural households in Vietnam
Authors: Mai Nguyen Thi
Published: June 2020

This study uses the data extracted from the Vietnam Access to Resources Household Survey 2008, 2010, 2012, 2014, 2016 on 2,107 rural households in Vietnam. Results from logit regressions show that: (1) natural disasters, plant or animal diseases, mean years of schooling of all labor members in the households, household size, levels of participation in associations and social organizations help to increase the ability of households to diversify when there is a risk; (2) On the contrary, the harmful impacts from pest of the previous year, mean years of schooling of household head, age, ethnicity, land area, attitude to risks exert a negative impact on the ability of income diversification. Thereby, the study offers some policy implications such as improving the educational level of the households, encouraging households to actively participate in training sessions, skills training and market access organized by the State and NGOs, disseminating knowledge on risk response measures through income diversification. The novel point of the study is the application of the microeconomic theory to measure the impact of attitude to risk on the decision to diversify income when risks occur. In addition, the study also examines the impact of each type of risk, and the severity of the risk on the choice of income diversification to cope with risks.
The impact of equitization on financial and operating performance of state-owned enterprises (SOEs) in Vietnam: An approach using propensity score matching
Authors: Tan Nguyen Van
Published: June 2020

This paper examines the impact of equitization on financial and operating performance of state-owned enterprises (SOEs) in Vietnam. Previous related privatization theories have not explained whether there is an improvement in financial and operating performance of equitized SOEs compared to non-equitized SOEs or not. This study proposes to use with-without comparison method through the average treatment effect measuring the impact of equitization on financial and operating performance of SOEs. By using data of 114 SOEs equitized in the period from 2012 to 2014, the author finds that equitized SOEs can not improve profitability, operating efficiency, and output when considering non-equitized SOEs. There is also no evidence for a reduction in the number of employees of equitized SOEs after equitization. These findings are in contrast to previous studies in Vietnam, but there are similarities with the results of studies in China. This is because equitized SOEs in the early post-equitization period in Vietnam are still monitored by the Vietnamese government, as well as the equitized enterprises in the period 2012-2014 are mainly large-scale ones with slow change of operating objectives, monitoring mechanism and weak competitiveness after equitization. However, equitization can help equitized SOEs operate more efficiently than non–equitized SOEs when considering non-listing status or industry group. This research provides implications for the Vietnamese government to encourage non-equitized enterprises to participate in the equitization program actively. The research results also help investors to have appropriate long-term investment strategies in equitized SOEs. This paper also has some limitations for further research.
Genç Futbolcularda Yüksek Şiddetli İnterval Antrenmanın Çeviklik Sürat ve Aerobik Performans Üzerine Etkisinin İncelenmesi
Authors: KÖSE Bereket , ATLI Ahmet
Published: June 2020

Bu çalışmanın amacı yüksek şiddetli interval antrenmanın genç futbolcularda çeviklik, sürat ve aerobik performans üzerine etkisini incelemektir. Çalışmaya deney grubu (n:10, yaş ort:19,65±0,51) ve kontrol grubu (n:10, yaş ort:18,88±0,62) olmak üzere 20 genç futbolcu katılmıştır. Çalışmada deney grubu normal futbol antrenmanlarına ek olarak haftada 3 kez yüksek şiddetli interval antrenman programını 7 hafta yapmıştır. Kontrol grubu ise sadece normal futbol antrenmanlarına devam etmiştir. Çalışmada ön test son test olarak pro-agility çeviklik testi, 30 metre sürat testi ve Yo-Yo aralıklı koşu testi uygulanmıştır. İstatistiksel hesaplamalar SPSS-20 paket programıyla yapılmış ve güven aralığı p<0,05 olarak kabul edilmiştir. Yapılan bu çalışmada deney grubunun sürat ve Yo-Yo aralıklı koşu testi özelliklerinin ön test son test karşılaştırmalarında son test değerlerinin istatistiksel anlamda daha iyi olduğu görülmektedir (p<0,05). Deney grubunun çeviklik ön test son test değerlerinde ise bir faklılık gözlenmemiştir (p>0,05). Kontrol grubunun ön test son test sürat ve çeviklik özelliklerinde bir farklılık bulunmazken (p>0,05) Yo-Yo aralıklı koşu testinde ise son test verileri anlamlı bir şekilde artış göstermiştir (p<0,05). Sonuç olarak yüksek şiddetli interval antrenman programlarının genç futbolcularda sürat ve aerobik dayanıklılığın bir göstergesi olan koşu mesafesini artırdığı görülmüştür.
Üniversite Öğrencilerinin Akademik Öz-Yeterlilik ve Yaşam Kalitelerinin Fiziksel Aktivite Yapma Durumlarına Göre İncelenmesi
Authors: HAMAD AMİN Bnar Muhamed , COSKUN OZYOL Funda
Published: June 2020

Bu çalışmanın temel amacı Van Yüzüncü Yıl Üniversitesi lisans öğrencilerinin akademik öz-yeterlik ve üniversite yaşam kalitesine ilişkin algılarını ve bu algıların cinsiyet ve fiziksel aktivite yapma durumuna göre farklılaşıp farklılaşmadığını incelemektir. Çalışmaya Van Yüzüncü Yıl Üniversitesi’nde eğitim gören ve yaşları 18 ile 29 arasında değişen 2185 kadın ve 2493 erkek olmak üzere toplam 4678 öğrenci katılmıştır. Kullanılan veri toplama araçları Kişisel Bilgi Formu, Üniversite Yaşam Kalitesi Ölçeği ve Akademik Öz-Yeterlik Ölçeği’dir. Elde edilen verilerin analizinde betimsel istatistikler ve Mann Whitney-U testi kullanılmıştır. Araştırma bulguları katılımcıların akademik öz-yeterlik puan ortalamalarının cinsiyete göre farklılaştığını (p<.01), erkek öğrencilerin akademik öz-yeterlik puanlarının kadın öğrencilerden yüksek olduğunu ve erkek öğrencilerin üniversite yaşamlarını daha kaliteli algıladıklarını ortaya koymuştur (p<.01). Ancak araştırmada, öğrencilerinin akademik öz-yeterlik ve üniversite yaşam kalitesi puanlarının fiziksel aktivite yapma durumuna göre farklılaşmadığı sonucu elde edilmiştir (p>.05). Sonuç olarak; üniversite öğrencilerinin üniversite yaşam kalitesi puanları ile akademik öz-yeterlik puanlarının cinsiyete göre farklılaştığı, ancak akademik öz-yeterlik ve üniversite yaşam kalitesi algılarının fiziksel aktivite yapma durumuna göre farklılaşmadığı görülmüştür.
Ksenophon Sosenko – Ukrainian folklorist, ethnographer, patriot
Authors: Shutak O. , Konoplenko N.
Published: June 2020

Many figures of Ukrainian culture are waiting for the recognition, study and promotion of their work. Among them is the representative of the Ukrainian intelligentsia at the end of the 19th – the first half of the 20th centuries – Ksenophon Sosenko, who played an important role in the folklore process in Galicia in the 20–30's of the last century. He was an adherent of the Viennese Cultural and Historical School, adopting its methodology, which he applied in his thorough and original works which still impress the scholarly erudition. The article attempts to characterize the life and scientific path of O. Ksenofont, to identify the main directions of research and its contribution to the history of Ukrainian folklore. Attention is drawn to how K. Sosenko illuminated the “moral image of the people”, as expressed by P. Kulish, having touched on the problems of ethno-ethics, emphasized the people's view of traditions as holiness, as a moral duty. The studies of the researcher are imbued with patriotism. K. Sosenko's desire in all his writings to prove the autochthonousness of the Ukrainians on their land was determined primarily by the political situation of the early XX century. When pessimism, panic, despair, and indifference prevailed in Ukraine after the unsuccessful national-political contests of 1917–1919, it was K. Sosenko's studies that once again aimed to reaffirm to the world that Ukrainians have their original history, rich and unique culture and, therefore, have the right to live on their own lands and on their state forever.
The Spiritual Pedagogy of St. John Paul II
Authors: Ohirko O. V. , Spilnyk L. A. , Yablonska I. P.
Published: June 2020

The article discusses the basics of spiritual pedagogy, which was distributed by the great humanist and teacher of mankind Pope John Paul II. Spiritual pedagogy is rooted in Scripture and the Christian religion, which tolerates and accepts everything that is true and noble in other non-Christian religions. It is indicated that John Paul II was a doctor of theology and a doctor of philosophy, an honorary doctor of ten different universities in the world. His approaches to understanding a person, his freedom and responsibility are examined. The problems of the spiritual and moral teachings of John Paul II are analyzed, concerning happiness, human dignity, and the problems of youth and elderly people. It is pointed out that the Holy Pope called for the creation of a civilization of mercy and the avoidance of the civilization of death. Attention is drawn to the scientific and pedagogical heritage of John Paul II, numbering 58 volumes. In the spiritual education of youth, the pope paid special attention to God's commandment of respect for parents. It is argued that the peculiarity of the spiritual pedagogy of John Paul II is the recognition of two priorities: uniqueness and integrity. The article analyzes the problem of family education, which occupies a special place in the spiritual pedagogy of John Paul II. It is indicated that family education contributes to the “humanization” of a person. It has been argued that the personal religious maturity of parents is a deep source of spirituality for children.
FACTORS THAT HAVE PROGNOSTIC VALUES IN THE MANAGEMENT OF NASOPHARYNGEAL CARCINOMA PATIENTS
Authors: Kangga Chandra , Utama Denny Satria
Published: June 2020

Introduction: The survival rate of Nasopharyngeal carcinoma (NPC) patients is influenced by several prognostic factors, Such aspatient factors, tumor factors and therapeutic interventions carried out as well as the quality of care. Tumor factors in the form of spread of local invasion, regional lymphatic involvementand metastasis that is reflected in the TNM stage (Tumor, Nodule and Metastatic) are the most important prognostic factors of NPC.

Objective: To determine the Prognostic factors that effectedsurvival rate of nasopharyngeal carcinoma patients.

Material and methods: Analytic observational studywith particular design of survival analysis. Data was taken from medical records and then performed survival analysis on the studiedfactors. Sample of this studywas all patients who were first diagnosed NPC From January 2013 until December 2013 and meetinclusion and exclusion criteria is52 patients.

Results:From 52 patients in the fifth year, 50% died and 50% survive. Survival was worse in the 30-39 year age group (30.8%), male sex (47.2%), Stage IV (44.4%), T4 size (40%), N1 size (23,1%), Distant metastases (40%), WHO type III (48.5%), chemoradiation (48.9%). In multivariate analysis, it was found that the variables that most influenced the survival of NPC patients based on p <0.05 and based on hazard ratio strength were T-size, N-size categories and Metastasis with 95% CI.

Conclusion: Prognostic factors that affect the survival of NPC patients in RSUP. Dr. Mohammad Hoesin Palembang is a category of size T, N, and Metastasis.
A Gestão de Resíduos Sólidos na cidade do Rio de Janeiro
Authors: Gomes Ellen de Magalhães , Estevez Alejandra , Santos Andreia Cesar dos , Kraemer Carlos , Sacramento Josiane , Thielmann Ricardo
Published: June 2020

O município do Rio de Janeiro é uma das capitais mais importantes do Brasil, atraindo não só pessoas de outros países para o turismo, como pessoas de outros estados, que buscam melhores oportunidades de trabalho, estudos e moradia. Essa procura faz com que o município tenha um aumento significativo da geração de resíduos sólidos em um espaço cada vez menor de tempo, exigindo da administração pública atitudes pertinentes para o manejo e descarte consciente e eficiente do lixo. O presente trabalho tem como objetivo principal identificar as políticas públicas atuantes no âmbito da gestão de resíduos sólidos no município do Rio de Janeiro, que abrange desde a identificação dos fatores de geração de lixo até a dificuldade de implantação de tecnologias que diminuam os impactos gerados, além de apontar as responsabilidades como cidadãos quanto à consciência ambiental tendo como ponto de partida a promulgação da Lei nº 12.306/10, que institui a Política Nacional de Resíduos Sólidos. A Lei exigiu dos municípios medidas concretas quanto a ao controle e descarte dos resíduos gerados pela população, tanto da sociedade civil quanto das empresas (em especial as de obras/construtoras). Analisando dados oficiais do município, artigos e livros dedicados a administração pública será feita uma leitura qualitativa dos dados, analisando os problemas e expondo as medidas adotadas pelo município para sanar as demandas. O assunto deve ser preconizado, pois a sustentabilidade está diretamente relacionada com o bem estar da sociedade e sua continuidade, pois o lixo gera emissões de gases tóxicos, poluição ambiental (rios, solos) que são nocivos a população global e gera complicações futuras ao meio ambiente.
Educação infantil, inclusão e a tecnologia assistiva
Authors: Florentino Priscila Elaine , Lopes Sandra Aparecida
Published: June 2020

O presente artigo visa investigar a respeito da importância da tecnologia assistiva para o desenvolvimento da educação da pessoa com deficiência, realizando um levantamento bibliográfico sobre a relação que a educação infantil tem com educação especial e inclusiva, sua trajetória e avanços no Brasil. A inclusão na Educação Infantil segue devido o reconhecimento da criança pequena como sujeito de direitos, protagonista de sua própria história. Aos poucos a criança pequena passa a ter papel social, direitos de aprendizagem e desenvolvimento. Como metodologia utilizou-se de pesquisa bibliográfica a autores como Delgado Garcia (2017), Bersch (2017), Galvão Filho (2013), entre outros, que escreveram em livros, revistas, jornais, etc. sobre a Educação Especial aliada a Educação Infantil e a importância da capacitação de seus professores, como forma de melhor atender a criança pequena e auxiliar em seu desenvolvimento integral. Portanto essa pesquisa espera auxiliar futuros leitores sobre a importância da Educação Especial ser utilizada dentro da Educação Infantil.
A responsabilidade do Estado pelas condutas omissivas de seus agentes na área da saúde
Authors: Rocha Alexandra Rayara da Silva , Rodrigues Eduardo Henrique Oliveira , Amaral Fernando Paiva Gomes do
Published: June 2020

Os agentes da área da saúde atribuem a responsabilidade ao Estado não apenas por suas condutas comissivas, mas também as omissivas, uma vez que a não ação onde em regra haveria o dever de agir também é punida. Esta pesquisa foi realizada com o intuito de descobrir de que maneira o agente pode ser responsabilizado pelas suas condutas omissivas na área da saúde, como também quais são as punições que este recebe. Os dados foram colhidos através de uma minuciosa pesquisa bibliográfica e jurisprudencial, a fim de apresentar informações doutrinárias, como também o que é adotado pelos tribunais brasileiros, a pesquisa ocorreu de maneira qualitativa. Constatou-se que há diversos entendimentos de como o Estado deve ser responsabilizado, mas que na prática, essa responsabilização ocorre através da existência de nexo entre a conduta omissiva e a lesão provocada, verificando-se não somente o resultado, mas qual a participação da Administração Pública neste.
Cycling Behaviour Changes as a Result of COVID-19: A Survey of Users in Sydney, Australia.
Authors: Lock Oliver
Published: June 2020

This research highlights transport findings related to individual and observed behaviours and self-reported attitudes towards cycling in Sydney, Australia during COVID-19 social distancing and lockdown restrictions in May, 2020. An online survey with n=250 participants collected data pertaining to the question “How has cycling behaviour potentially changed as a result of COVID-19?”. Thematic analysis is used to summarise the changes documented by these individuals - such as increased number of cyclists, increased volume of families and children on roads, reduced traffic, increased imperative for new cycle infrastructure and potential new permanent changes in their commuting behaviour away from public transport.
TRATAMENTOS PRÉ-GERMINATIVOS E SUBSTRATOS NA GERMINAÇÃO DE SEMENTES E BIOMETRIA DE PLÂNTULAS DE Hymenaea courbaril L. var. Stilbocarpa
Authors: Pagliarini Maximiliano Kawahata , Castilho Regina Maria Monteiro de , Nasser Flávia Aparecida de Carvalho Mariano , Alves Marlene Cristina
Published: June 2020

O presente trabalho objetivou testar a influência de tratamentos pré-germinativos e de diferentes substratos na germinação de sementes, biometria de plântulas e teor de clorofila de folhas de jatobá (Hymenaea courbaril). O experimento foi realizado na UNESP, Campus de Ilha Solteira - SP, em casa de vegetação do tipo Pad & Fan, de março a abril de 2011. As sementes foram submetidas aos seguintes tratamentos pré-germinativos: imersão em água por 12 horas, imersão em água por 24 horas, escarificação mecânica, escarificação mecânica+ imersão em água por 12 horas, escarificação mecânica+ imersão em água por 24 horas e controle. A escarificação foi realizada no lado oposto à micrópila utilizando lixa n° 80. Após tratadas, as sementes foram colocadas para germinar em copos plásticos de 300 mL preenchidos com quatro diferentes tipos de substrato: substrato comercial, vermiculita, areia e resíduo de celulose. Foram avaliadas a porcentagem de germinação, o índice de velocidade de germinação (IVG), o tempo médio de germinação (TMG), a altura das plântulas, o diâmetro de caule e o teor de clorofila das folhas. O experimento foi um fatorial 6 x 4 em delineamento inteiramente casualizado, com quatro repetições de oito sementes. O melhor tratamento pré-germinativo foi escarificação mecânica com lixa n° 80 no lado oposto à micrópila + imersão em água por 24 horas. A areia e o substrato comercial são recomendados para germinação e crescimento as mudas de jatobá.
EFEITO DE DIFERENTES CONDIÇÕES DE LUMINOSIDADE E SUBSTRATOS NO DESENVOLVIMENTO INICIAL DE GRAMA BERMUDA
Authors: Amaral João André do , Castilho Regina Maria Monteiro de , Haga Kuniko Iwamoto
Published: June 2020

A luminosidade e o tipo de substrato utilizado na implantação de gramados são alguns dos fatores que devem ser considerados na escolha da espécie de grama. Com a realização de eventos esportivos internacionais nos últimos anos no país, houve a necessidade de alterações arquitetônicas nas arenas, com a implantação de coberturas, aumentando o sombreamento do gramado e, deste modo, o presente estudo teve por objetivo avaliar a influência da luminosidade e de diferentes substratos no desenvolvimento inicial de grama bermuda (Cynodon dactylon x C. transvaalensis). O experimento foi conduzido no Campus II - UNESP, de Ilha Solteira ? SP, em esquema fatorial 5 x 4 (substratos x luminosidades), em delineamento inteiramente casualizado com 20 tratamentos e 3 repetições. Os substratos foram: S1 = Solo, S2 = Solo + areia (2:1), S3 = Solo + matéria orgânica (1:1), S4 = Solo + matéria orgânica + areia (2:1:1) e S5 = Matéria orgânica + areia (3:1), em 4 condições de luminosidade (pleno sol, 30%, 50%, 80% de sombreamento), durante os meses de março de 2014 a agosto de 2014. Foram avaliados: Comprimento médio da parte aérea do gramado e massa fresca e massa seca das folhas. Foi possível concluir que níveis mais intensos de sombreamento estimularam o crescimento em comprimento da parte aérea da grama, porém houve uma redução no acúmulo de massa fresca e seca.
Framing Integration – from Welfare to Citizenship
Authors: Ihle Ragnhild
Published: June 2020

This article will study the contested concept of integration in Norway through a frame analysis approach. The aim is to study different understandings of the term “integration” as it is presented in a select body of policy documents in Norway. The methodology involved is to search in the documents and in relevant research for various interpretations of the concept, and relate them to diagnostic framing, prognostic framing and motivational framing. This method is associated with both critical frame analysis and genealogy. The analysis defines a timeline, from 1975 forward, of six concepts of integration: 1) individuals in need, care and clientification; 2) preservation of culture – a tribute to colourful community; 3) the upheaval of living conditions in specific social groups; 4) absence of structural barriers, racism and discrimination; 5) living conditions, identity and belonging; 6) Influence, participation and activation. The frames related to these concepts will expose conceptual prejudices, detect inconsistencies, challenge generalisations, and give visibility to the processes of exclusion.
A défaut de dire tout: dire partout. Étude des modes énonciatifs dans Le mespris de la vie et consolation contre la mort de Jean-Baptiste Chassignet
Authors: Lachance Isabelle
Published: June 2020

Poésie maniériste? Baroque? Le mespris de la vie et consolation contre la mort (1594) peut-être le résultat de multiples influences, et chaque situation d'énonciation de ce recueil comporte sa manière propre de structurer les courants idéologiques de l'époque à laquelle il a été écrit, et ce, dans un but didactique d'illustration, comme le précise d'ailleurs la "Preface au lecteur." Les Essais sont sûrement l'une de ces influences. Toutefois, alors que chez Montaigne le moi constitue "une médiation pour connaître le monde," chez Chassignet, le "je" est au service de l'illustration. On aura beau chercher à tort et à travers la "mélancolie de Chassignet" ou l'expression de son "moi clivé," le seul affect qu'il est possible de reconstituer à la lecture du recueil est celui du sujet partout dépeint comme la figure exemplaire du pécheur.
On Reading La Puce de Madame Des-Roches: Catherine des Roches's Responces (1583)
Authors: Larsen Anne R.
Published: June 2020

Catherine des Roches's authorial participation in the famous poetic flea contest during the Grands Jours of Poitiers in 1579 was all but forgotten a decade and a half after her death when Estienne Pasquier claimed the volume of La Puce de Madame Des-Roches as his own by eliminating her name from the title in his collective work La jeunesse d'Estienne Pasquier (1610). As if sensing such a fate and wishing above all to remind her readers of her literary contribution to the contest, Catherine des Roches published her flea poems as responces in her Secondes oeuvres (1583). This study proposes several possible reasons for her inclusion of these replies in her second volume of collected works.
Artifice, Memory, and Reformatio in Hieronymus Natalis's Adnotationes et meditationes in Evangelia
Authors: Melion Walter S.
Published: June 2020

Composed by Hieronymus Natalis at the behest of Ignatius of Loyola, the Adnotationes et meditationes in Evangelia is a key Jesuit propaedeutic that instructs novices in the rhetoric of prayer, teaching them how to convert Gospel liturgy into the matter of contemplative devotion. Using a system of annotations and meditations based on the rhetorical principle of definitio per descriptionem, Natalis expounds a series of 153 engravings that depict Christ's life, death, and resurrection. These prints set Gospel places and events within landscape panoramas that map a series of peregrinationes, sacred journeys, whose meaning and scope the votary is invited to consider and retrace. By negotiating between panoramic prints and richly embellished texts, the novice learns to trope his own journey, which becomes a figure of the kinds and degrees of prayer he has traversed. This paper examines how the annotations and meditations on the Annunciation, Visitation, Adoration of the Magi and Christ and the Canaanite Woman, encourage the Jesuit to embrace reformatio, spiritual conversion, using prayer to find the meaning of his vocation and the strength to engage in it fully.
The Neoplatonic Logic of Richard Hooker's Generic Division of Law
Authors: Kirby W. J. Torrance
Published: June 2020

Richard Hooker's theology of Law is rooted in a twofold argument: the systematic appropriation of the neoplatonic structure of argument and an appeal to protestant conceptions of Nature and Grace. This paper offers a close reading of Hooker's Of the Lawes of Ecclesiasticall Politie in an attempt to understand the articulation between Natural and Eternal Laws.
The End of Chivalric Romance: Barthélemy Aneau's Alector (1560)
Authors: Krause Virginia
Published: June 2020

Lorsque l'Alector de Barthélemy Aneau est paru en 1560, le roman de chevalerie attirait de vives critiques. Il est donc surprenant qu'un humaniste sérieux, tel que l'était Aneau, ait emprunté largement aux conventions romanesques, autant nouvelles (suspens) qu'anciennes (chevalier errant, aventure chevaleresque, quête). Encore plus frappante est son intention déclarée d'imposer un dessein moral et narratif sur un genre défini par son manque de clôture. Le présent article explore le projet d'Aneau de racheter les égarements du roman au moyen de l'allégorie, comprise comme agent fragile du projet moral et de la vérité humanistes contre lesquels conspirent les errements de l'intrigue.
Recovering the Curse of Eve: John Donne's Churching Sermons
Authors: Johnson Jeffrey
Published: June 2020

L'office liturgique de relevailles ("Churching of Women after Childbirth"), tout en ayant son origine dans les lois de purification détaillées au Lévitique 12, s'était néanmoins transformé, à l'époque où John Donne servait de prêtre, en occasion surtout sociale. Les deux sermons de relevailles de Donne qui ont été préservés répondent à cette tendance en situant la pratique dans un contexte de repentir collectif. En particulier, Donne aligne les relevailles sur le sacrement de baptême; dans cette optique, la purification qu'il préscrit, encore que liée au nettoyage corporel, est élargie théologiquement pour illustrer le besoin de toute l'humanité d'être lavée de sa déchéance.
Faking It: A Case of Counterfeit Possession in the Reign of James I
Authors: Raiswell Richard
Published: June 2020

En 1622, au printemps, l'adolescente Katheren Malpas, sa mère et ses grands-parents du côté maternel ont été inculpés dans le Star Chamber pour avoir cyniquement organisé une possession démoniaque frauduleuse afin de profiter de la charité de leurs voisins. En puisant dans le procés-verbal détaillé, le présent article reconstruit le mécanisme de l'imposture et attribue son écroulement à une tension épistémologique. Les comploteurs ont été coincés entre les exigences du discours démoniaque populaire et le besoin, de plus en plus imposé par l'état depuis le cas notoire de Mary Glover, de fournir des preuves des phénoménes surnaturels. D'ailleurs, la composition sociale changeante de la paroisse, qui autrefois était largement rurale, faisait en sorte qu'ils avaient deux publics à satisfaire simulanément. De cette contradiction inhérente dans leur entreprise découlait son échec.
LA MODERNIDAD DOMÉSTICA EN EL SECTOR NORTE DE LA CIUDAD DE CUENCA: IDENTIFICACIÓN Y DOCUMENTACIÓN, EJEMPLOS, TIPOS Y VARIACIONES
Authors: Minchala-Leon Marco Antonio , Sinchi-Toral Iván Paúl
Published: June 2020

Se parte de la hipótesis de que la arquitectura doméstica del sector norte de la ciudad de Cuenca, representa un ejemplo de modernidad en el contexto local. Por esta razón, la investigación, en convenio con el Instituto Nacional de Patrimonio Cultural (INPC), se centró en descubrir este grado de modernidad, desde un muestreo de 11 manzanas que sintetiza la serie de planes de ordenamiento del sector norte en Cuenca. La metodología fue el análisis visual y fotográfico, con el que se identificaron y valoraron 33 viviendas, según los atributos modernos de equilibrio, equivalencia y clasificación; de cuyas variaciones se identificaron tres tipos arquitectónicos residenciales.Palabras clave: Modernidad, equilibrio, equivalencia, clasificación, catálogo, atributos de la forma moderna, casa moderna cuencana.

AbstractThere is the assumption that domestic architecture within the northern area of Cuenca-Ecuador represents high-qualified examples of modernity in its local context. That is why, this research, in agreement with the National Ecuadorean Institute of Cultural Heritage (INPC), was focused on finding out its modernity degree.  A sampling of 11 blocks within the northern area summarized its spatial planning. Its methodology consisted on a visual and photographic analysis, in which 33 houses were identified and assessed, according to modern formal criteria of equilibrium, equivalence and classification; from its variations three architectural typologies were identified.

Keywords: Modernity, equilibrium, equivalence, classification, catalog, attributes of modern form, modern Ecuadorian dwelling.
İLK RESMİ SPOR DERGİSİ:TÜRK SPOR KURUMU DERGİSİ’NE (1936-1938) BİR BAKIŞ
Authors: EKEN Faruk
Published: June 2020

1930’lu yıllar Türkiye’sinde spor dergiciliğinin önceki dönemlere göre artış gösterdiği bilinmektedir. 1920’li yıllarda Gol Spor Mecmuası, Spor Alemi, Yarın Spor, Türkspor’un ardından 1930 yıllarda Türkspor, Olimpiyat, Top, Spor Postası, Kırmızı Beyaz, Türk Spor Kurumu, Sarı Lacivert, Havacılık ve Spor ve Beden Terbiyesi ve Spor ile Okul Spor basın hayatında yerlerini almışlardır. Bu dergiler içerisinde Türk Spor Kurumu Dergisi spor teşkilatında meydana gelen bir değişiklikten sonra oluşturulan Türk Spor Kurumu’nun resmi yayın organı olarak faaliyetini sürdürmüştür. Yayın politikası ve haberlerin işlenişi noktasında geçiş döneminin bir ürünü olan dergi, resmi bir yayın organı olarak çalışmıştır. Haberlerin aktarımından sporla ilgili haberlere kadar yapmış olduğu yayın ile Türk spor teşkilatlanmasına katkı sağlamıştır.
Inhotim: o paisagismo e a identidade do jardim botânico
Authors: Mota Nayara Mesquita , Borin Juliano César , Framil Filipe Lorenzo , Carmo Sabrina Silva
Published: June 2020

A transformação da paisagem pela combinação singular de arte contemporânea e botânica é uma marca do Instituto Inhotim. Uma combinação que estimula reflexões sobre cultura e biodiversidade. Devido ao paisagismo diverso e intenso, seu acervo botânico tornou-se tão relevante que, associado a outros fatores, permitiu o reconhecimento do Inhotim como jardim botânico em 2010. Esse trabalho demonstra como o paisagismo é o principal fio condutor das práticas do Inhotim enquanto jardim botânico, apresentando práticas atuais e desafios futuros. A partir do paisagismo, outras questões relevantes surgem, como a conservação da biodiversidade, a sustentabilidade e a educação ambiental. Tais questões levaram a práticas como a busca pela gestão sustentável dos recursos naturais, a pesquisa científica, a conservação de remanescentes florestais, a divulgação do conhecimento botânico através da sinalização do acervo, entre outras. Muitos desafios permanecem, mas o reconhecimento da identidade do jardim botânico movido pelo paisagismo permite o fortalecimento dessas atividades.
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Authors: Paubrasilia Revista
Published: June 2020

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The Role of PI3K/AKT Pathway and NADPH Oxidase 4 in Host ROS Manipulation by Toxoplasma gondii
Authors: Choi Hei Gwon , Gao Fei-Fei , Zhou Wei , Sun Pu-Reum , Yuk Jae-Min , Lee Young-Ha , Cha Guang-Ho
Published: June 2020

Dendritic cell is one of the first innate immune cell to encounter T. gondii after the parasite crosses the host intestinal epithelium. T. gondii requires intact DC as a carrier to infiltrate into host central nervous system (CNS) without being detected or eliminated by host defense system. The mechanism by which T. gondii avoids innate immune defense of host cell, especially in the dendritic cell is unknown. Therefore, we examined the role of host PI3K/AKT signaling pathway activation by T. gondii in dendritic cell. T. gondii infection or T. gondii excretory/secretory antigen (TgESA) treatment to the murine dendritic cell line DC2.4 induced AKT phosphorylation, and treatment of PI3K inhibitors effectively suppressed the T. gondii proliferation but had no effect on infection rate or invasion rate. Furthermore, it is found that T. gondii or TgESA can reduce H2O2-induced intracellular reactive oxygen species (ROS) as well as host endogenous ROS via PI3K/AKT pathway activation. While searching for the main source of the ROS, we found that NADPH oxidase 4 (NOX4) expression was controlled by T. gondii infection or TgESA treatment, which is in correlation with previous observation of the ROS reduction by identical treatments. These findings suggest that the manipulation of the host PI3K/AKT signaling pathway and NOX4 expression is an essential mechanism for the down-regulation of ROS, and therefore, for the survival and the proliferation of T. gondii.
Spatiotemporal Trends of Malaria in Relation to Economic Development and Cross-Border Movement along the China–Myanmar Border in Yunnan Province
Authors: Zhao Xiaotao , Thanapongtharm Weerapong , Lawawirojwong Siam , Wei Chun , Tang Yerong , Zhou Yaowu , Sun Xiaodong , Sattabongkot Jestumon , Kaewkungwal Jaranit
Published: June 2020

The heterogeneity and complexity of malaria involves political and natural environments, socioeconomic development, cross-border movement, and vector biology; factors that cannot be changed in a short time. This study aimed to assess the impact of economic growth and cross-border movement, toward elimination of malaria in Yunnan Province during its pre-elimination phase. Malaria data during 2011-2016 were extracted from 18 counties of Yunnan and from 7 villages, 11 displaced person camps of the Kachin Special Region II of Myanmar. Data of per-capita gross domestic product (GDP) were obtained from Yunnan Bureau of Statistics. Data were analyzed and mapped to determine spatiotemporal heterogeneity at county and village levels. There were a total 2,117 malaria cases with 85.2% imported cases; most imported cases came from Myanmar (78.5%). Along the demarcation line, malaria incidence rates in villages/camps in Myanmar were significantly higher than those of the neighboring villages in China. The spatial and temporal trends suggested that increasing per-capita GDP may have an indirect effect on the reduction of malaria cases when observed at macro level; however, malaria persists owing to complex, multi-faceted factors including poverty at individual level and cross-border movement of the workforce. In moving toward malaria elimination, despite economic growth, cooperative efforts with neighboring countries are critical to interrupt local transmission and prevent reintroduction of malaria via imported cases. Cross-border workers should be educated in preventive measures through effective behavior change communication, and investment is needed in active surveillance systems and novel diagnostic and treatment services during the elimination phase.