bluuebunny/crossref_metadata_2025 huggingface dataset:
Feeling Touched: Empathy Is Associated With Performance in a Tactile Acuity Task
Authors: Schaefer Michael , Joch Marcel , Rother Nikolas
Published: February 2021

The concept of empathy describes our capacity to understand the emotions and intentions of others and to relate to our conspecifics. Numerous studies investigated empathy as a state as well as a stable personality trait. For example, recent studies in neuroscience suggest, among other brain areas such as the insula or the ACC, a role of the somatosensory cortices for empathy (e.g., when observing someone else being touched). Since the classic understanding of the primary somatosensory cortex is to represent touch on the body surface, we here aimed to test whether tactile performance is linked to the personality trait empathy. To test this, we examined the tactile acuity of 95 healthy participants (mean age 31 years) by using a two-point discrimination threshold task at the index fingers. Trait empathy was assessed by employing the interpersonal reactivity index (IRI), which measures self-reported empathy with four scales (empathic concern, perspective taking, fantasy, and personal distress). Results of regression analyses suggested the subscale empathic concern to be positively associated with performance in the tactile acuity task. We discuss this finding in the light of recent studies on empathy and consider possible implications of tactile training to enhance empathy.
RETRACTED: Long Non-Coding RNA ELFN1-AS1 Promoted Colon Cancer Cell Growth and Migration via the miR-191-5p/Special AT-Rich Sequence-Binding Protein 1 Axis
Authors: Du Yongjun , Hou Yanmei , Shi Yongbo , Liu Juan , Li Tingxin
Published: February 2021

Long non-coding RNAs (lncRNAs) are reported to participate in tumor development. It has been manifested in previous researches that lncRNA ELFN1-AS1 is involved in early-stage colon adenocarcinoma with potential diagnostic value. However, no studies have revealed the specific mechanism of ELFN1-AS1 in colon cancer, and there are no other studies on whether ELFN1-AS1 is associated with tumorigenesis. In our study, ELFN1-AS1 with high expression in colon cancer was selected by TCGA analysis, and the survival analysis was carried out to verify it. Subsequently, qRT-PCR was adopted for validating the results in tissues and cell lines. Cell counting kit-8 (CCK8), 5-ethynyl-2’-deoxyuridine (EdU), cell colon, cell apoptosis, cell cycle, cell migration, and invasion assays were utilized to assess the role of ELFN1-AS1 in colon cancer. Results uncovered that ELFN1-AS1 expression was prominently raised in colon cancer cells and tissues. ELFN1-AS1 decrement restrained cells to grow through interfering with distribution of cell cycle and promoting apoptosis. Meanwhile, ELFN1-AS1 decrement weakened the capacity of cells to migrate and invade. What’s more, ELFN1-AS1 was uncovered to act as a competing endogenous RNA (ceRNA) to decrease miR-191-5p expression, thus raising special AT-rich sequence-binding protein 1 (SATB1), a downstream target of ceRNA. To sum up, ELFN1-AS1 drives colon cancer cells to proliferate and invade through adjusting the miR-191-5p/SATB1 axis. The above results disclose that lncRNA ELFN1-AS1 is possibly a novel treatment target for colon cancer cases.
Low Expression of the Polycomb Protein RING1 Predicts Poor Prognosis in Human Breast Cancer
Authors: Gao Song , Wang Si-Yu , Zhang Xing-Da , Wu Hao , Pang Da
Published: February 2021

Background

To date, breast cancer remains the most common malignant tumor in women. In recent years, a growing number of studies on polycomb proteins have been conducted. The Ring finger protein1 (RING1), an essential component of the polycomb family of proteins, plays vital roles in the tumorigenesis of various cancer types. However, further research is required in determining RING1 expression and prognostic value in breast cancer.

Method

RING1 expression level in multiple cancer types was evaluated using the XENA and UALCAN databases. Real-time quantitative PCR (real-time qPCR) and immunohistochemistry (IHC) were used to confirm this expression. The prognostic value was analyzed using our follow-up data and the Kaplan–Meier plotter website. RING1 co-expressed genes and its promoter methylation level were calculated using the cBioPortal and UALCAN online tools. The gene ontology (GO) and the Kyoto encyclopedia of Genes and Genomes (KEGG) pathway enrichment were analyzed using the DAVID online analysis tool.

Result

RING1 expression was upregulated in CHOL (Bile Duct Cancer), ESCA (Esophageal Cancer), LIHC (Liver Cancer), and PCPG (Pheochromocytoma & Paraganglioma). However, its expression level was decreased in COAD (Colon Cancer), KICH (Kidney Chromophobe), KIRP (kidney papillary cell carcinoma), THCA (Thyroid Cancer), and BRCA (Breast carcinoma). RING1 low expression is an unfavorable prognostic factor in many cancer patients, especially in breast cancer patients. For breast cancer, the IHC result showed that RING1 protein expression significantly and negatively correlates with tumor size (P = 0.029), LNM (P = 0.017), TNM stage (P = 0.016), ER (P = 0.005), Ki67 (P = 0.015), and p53 status (P = 0.034). Moreover, the multivariate Cox regression model indicated that RING1 (P = 0.038) and ER (P = 0.029) expressions were independent prognostic markers for breast cancer. RING1 co-expressed genes were selected and included HDAC10, PIN1, CDK3, BAX, and BAD. GO analysis and KEGG pathway analyses revealed that RING1 related genes, were mainly enriched in “regulation of transcription”, “apoptotic process”, “protein transport”, “protein binding”, “Notch signaling pathway”, and “Homologous recombination”.

Conclusion

RING1 expression was downregulated in breast cancer, and its low expression was associated with worse disease outcomes. RING1 may act as a new prognostic biomarker for breast cancer.
Efficacy and Safety of Qishen Yiqi Dripping Pill for Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis
Authors: Wang Mengxi , Shan Yiwen , Wu Chenjie , Cao Peihua , Sun Weixin , Han Jie , Shen Le , Chen Jiandong , Yu Peng , Chen Xiaohu
Published: February 2021

Background: The number of heart failure with preserved ejection fraction (HFpEF) patients is increasing year by year, yet all western medicines currently used for heart failure have been shown to be ineffective for HFpEF. Qishen Yiqi Dripping Pill is one of the commonly drugs for the treatment of heart failure in China. In recent years, some clinical studies found that it has curative effect on HFpEF.

Objective: To evaluate the efficacy and safety of Qishen Yiqi Dripping Pill in treatment of HFpEF.

Methods: Databases including CNKI, Wanfang, VIP, CBM, PubMed, Web of Science, The Cochrane Library and EMbase were searched from their inception to May 2020 to screen relevant randomized controlled trials. The “risk of bias” evaluation tool in the Cochrane Handbook was used to evaluate the quality of the included studies. RevMan 5.3 software was used for meta-analysis.

Results: Eight studies meeting the criteria were included, with a total of 895 patients. The results of meta-analysis showed that compared with western medicine alone, combination of western medicine and Qishen Yiqi Dripping Pill can further increase the quotient of early diastolic mitral inflow velocity and late diastolic mitral inflow velocity (E/A) in patients with HFpEF [mean difference (MD) = 0.20, 95% CI (0.14, 0.26), p < 0.000 01], decrease the quotient of early diastolic mitral inflow velocity and mitral annular tissue velocity (E/e′) [MD = −2.50, 95% CI (−3.18, −1.82), p < 0.000 01], decrease brain natriuretic peptide (BNP) [MD = −151.83, 95% CI (−245.78, −57.89), p = 0.002], increase cardiac function improvement rate [relative risk (RR) = 1.30, 95% CI (1.11, 1.52), p = 0.001], and increase six-minutes walking distance (6-MWD) [MD = 64.75, 95% CI (22.65, 106.85), p = 0.003]. Four studies reported the occurrence of adverse reactions, among which three studies reported no adverse reactions and one study reported three patients with mild adverse reactions in the intervention group.

Conclusion: Current evidence suggests that Qishen Yiqi Dripping Pill may be effective in the treatment of HFpEF. However, due to the low quality of the included studies, lack of placebo control, large heterogeneity among different studies, and great possibility of publication bias, the results of our review should be evaluated with more prudence, more high-quality clinical studies are needed to verify the conclusion in the future. In addition, the safety of Qishen Yiqi Dripping Pill remains uncertain, further assessment is required in the future.
DNA Repair Pathways in Cancer Therapy and Resistance
Authors: Li Lan-ya , Guan Yi-di , Chen Xi-sha , Yang Jin-ming , Cheng Yan
Published: February 2021

DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression of cancer. As the primary anti-cancer therapies, ionizing radiation and chemotherapeutic agents induce cell death by directly or indirectly causing DNA damage, dysregulation of the DNA damage response may contribute to hypersensitivity or resistance of cancer cells to genotoxic agents and targeting DNA repair pathway can increase the tumor sensitivity to cancer therapies. Therefore, targeting DNA repair pathways may be a potential therapeutic approach for cancer treatment. A better understanding of the biology and the regulatory mechanisms of DNA repair pathways has the potential to facilitate the development of inhibitors of nuclear and mitochondria DNA repair pathways for enhancing anticancer effect of DNA damage-based therapy.
TOXPANEL: A Gene-Set Analysis Tool to Assess Liver and Kidney Injuries
Authors: Schyman Patric , Xu Zhen , Desai Valmik , Wallqvist Anders
Published: February 2021

Gene-set analysis is commonly used to identify trends in gene expression when cells, tissues, organs, or organisms are subjected to conditions that differ from those within the normal physiological range. However, tools for gene-set analysis to assess liver and kidney injury responses are less common. Furthermore, most websites for gene-set analysis lack the option for users to customize their gene-set database. Here, we present the ToxPanel website, which allows users to perform gene-set analysis to assess liver and kidney injuries using activation scores based on gene-expression fold-change values. The results are graphically presented to assess constituent injury phenotypes (histopathology), with interactive result tables that identify the main contributing genes to a given signal. In addition, ToxPanel offers the flexibility to analyze any set of custom genes based on gene fold-change values. ToxPanel is publically available online at https://toxpanel.bhsai.org. ToxPanel allows users to access our previously developed liver and kidney injury gene sets, which we have shown in previous work to yield robust results that correlate with the degree of injury. Users can also test and validate their customized gene sets using the ToxPanel website.
Inspiratory Efforts, Positive End-Expiratory Pressure, and External Resistances Influence Intraparenchymal Gas Redistribution in Mechanically Ventilated Injured Lungs
Authors: Pellegrini Mariangela , Hedenstierna Göran , Larsson Anders Sune , Perchiazzi Gaetano
Published: February 2021

Background

Potentially harmful lung overstretch can follow intraparenchymal gas redistribution during mechanical ventilation. We hypothesized that inspiratory efforts characterizing spontaneous breathing, positive end-expiratory pressure (PEEP), and high inspiratory resistances influence inspiratory intraparenchymal gas redistribution.

Methods

This was an experimental study conducted on a swine model of mild acute respiratory distress syndrome. Dynamic computed tomography and respiratory mechanics were simultaneously acquired at different PEEP levels and external resistances, during both spontaneous breathing and controlled mechanical ventilation. Images were collected at two cranial–caudal levels. Delta-volume images (ΔVOLs) were obtained subtracting pairs of consecutive inspiratory images. The first three ΔVOLs, acquired for each analyzed breath, were used for the analysis of inspiratory pendelluft defined as intraparenchymal gas redistribution before the start of inspiratory flow at the airway opening. The following ΔVOLs were used for the analysis of gas redistribution during ongoing inspiratory flow at the airway opening.

Results

During the first flow-independent phase of inspiration, the pendelluft of gas was observed only during spontaneous breathing and along the cranial-to-caudal and nondependent-to-dependent directions. The pendelluft was reduced by high PEEP (p < 0.04 comparing PEEP 15 and PEEP 0 cm H2O) and low external resistances (p < 0.04 comparing high and low external resistance). During the flow-dependent phase of inspiration, two patterns were identified: (1) gas displacing characterized by large gas redistribution areas; (2) gas scattering characterized by small, numerous areas of gas redistribution. Gas displacing was observed at low PEEP, high external resistances, and it characterized controlled mechanical ventilation (p < 0.01, comparing high and low PEEP during controlled mechanical ventilation).

Conclusions

Low PEEP and high external resistances favored inspiratory pendelluft. During the flow-dependent phase of the inspiration, controlled mechanical ventilation and low PEEP and high external resistances favored larger phenomena of intraparenchymal gas redistribution (gas displacing) endangering lung stability.
The Physiological Mechanisms of the Sex-Based Difference in Outcomes of COVID19 Infection
Authors: Wray Susan , Arrowsmith Sarah
Published: February 2021

The scale of the SARS-CoV-2 pandemic has thrust a spotlight on the sex-based differences in response to viral diseases; morbidity and mortality are greater in men than women. We outline the mechanisms by which being female offers a degree of protection from COVID19, that persists even when confounders such as comorbidities are considered. The physiological and immunological mechanisms are fascinating and range from incomplete X chromosome inactivation of immune genes, a crucial role for angiotensin converting enzyme 2 (ACE2), and regulation of both immune activity and ACE2 by sex steroids. From this flows understanding of why lung and other organs are more susceptible to COVID19 damage in men, and how their distinct immunological landscapes need to be acknowledged to guide prognosis and treatment. Pregnancy, menopause, and hormone replacement therapy bring changed hormonal environments and the need for better stratification in COVID19 studies. We end by noting clinical trials based on increasing estrogens or progesterone or anti-testosterone drugs; excellent examples of translational physiology.
The Specific Judo Training Program Combined With the Whole Body Cryostimulation Induced an Increase of Serum Concentrations of Growth Factors and Changes in Amino Acid Profile in Professional Judokas
Authors: Jaworska Joanna , Laskowski Radoslaw , Ziemann Ewa , Zuczek Klaudia , Lombardi Giovanni , Antosiewicz Jedrzej , Zurek Piotr
Published: February 2021

This study aimed to evaluate the effect of a specific training program, supported by 10 sessions of whole body cryostimulation, on growth factors concentrations, amino acids profile and motor abilities in professional judokas. Ultimately, twelve athletes took part in the study. They were randomly assigned to the cryostimulation group (CRY, n = 6) or the control group (CON, n = 6). During 2 weeks of the judo training program, the CRY group performed 10 cryo-sessions (3-min, at a temperature of −110°C) and the CON group rested passively. Anthropometric measurements, a strength test, the Special Judo Efficiency Test (SJET) were assessed 2 days before and after the judo training program. Blood samples were collected at rest, 1 h after the first and the second SJET and 1 h after the first and the last cryo-session to establish growth factors and amino acid concentrations. Lactate level was measured before, immediately after and 1 h after the first and the second SJET. The applied intervention resulted in a significant increase of resting concentrations of brain-derived neurotrophic factor (from 10.23 ± 1.61 to 15.13 ± 2.93 ng⋅ml–1; p = 0.01) and insulin-like growth factor 1 (IGF-1; from 174.29 ± 49.34 to 300.50 ± 43.80 pg⋅ml–1; p = 0.00) in the CRY group. A different response was registered 1 h directly post SJET in the CRY group (a significant increase of IGF-1, interleukin 15 and irisin: p = 0.01; p = 0.00; p = 0.03). Additionally, the significant drop of proline and leucine concentrations in the CRY group was obtained. Athletes’ performance remained unchanged in both groups. However, subjects perceived positive changes induced by the intervention – not directly after cryostimulation but in response to the specific training workload. The increase of growth factors concentrations and the improvement of amino acid profile (proline and leucine) contributed to maintaining a high level of muscle function.
AtFUT4 and AtFUT6 Are Arabinofuranose-Specific Fucosyltransferases
Authors: Soto Maria J. , Prabhakar Pradeep Kumar , Wang Hsin-Tzu , Backe Jason , Chapla Digantkumar , Bartetzko Max , Black Ian M. , Azadi Parastoo , Peña Maria J. , Pfrengle Fabian , Moremen Kelley W. , Urbanowicz Breeanna R. , Hahn Michael G.
Published: February 2021

The bulk of plant biomass is comprised of plant cell walls, which are complex polymeric networks, composed of diverse polysaccharides, proteins, polyphenolics, and hydroxyproline-rich glycoproteins (HRGPs). Glycosyltransferases (GTs) work together to synthesize the saccharide components of the plant cell wall. The Arabidopsis thaliana fucosyltransferases (FUTs), AtFUT4, and AtFUT6, are members of the plant-specific GT family 37 (GT37). AtFUT4 and AtFUT6 transfer fucose (Fuc) onto arabinose (Ara) residues of arabinogalactan (AG) proteins (AGPs) and have been postulated to be non-redundant AGP-specific FUTs. AtFUT4 and AtFUT6 were recombinantly expressed in mammalian HEK293 cells and purified for biochemical analysis. We report an updated understanding on the specificities of AtFUT4 and AtFUT6 that are involved in the synthesis of wall localized AGPs. Our findings suggest that they are selective enzymes that can utilize various arabinogalactan (AG)-like and non-AG-like oligosaccharide acceptors, and only require a free, terminal arabinofuranose. We also report with GUS promoter-reporter gene studies that AtFUT4 and AtFUT6 gene expression is sub-localized in different parts of developing A. thaliana roots.
Mycorrhizal Communities and Isotope Signatures in Two Partially Mycoheterotrophic Orchids
Authors: Jacquemyn Hans , Brys Rein , Waud Michael , Evans Alexandra , Figura Tomáš , Selosse Marc-André
Published: February 2021

Partial mycoheterotrophy, the ability of plants to obtain carbon from fungi throughout their life cycle in combination with photosynthesis, appears to be more common within the Plant Kingdom than previously anticipated. Recent studies using stable isotope analyses have indicated that isotope signatures in partially mycoheterotrophic plants vary widely among species, but the relative contributions of family- or species-specific characteristics and the identity of the fungal symbionts to the observed differences remain unclear. Here, we investigated in detail mycorrhizal communities and isotopic signatures in four co-occurring terrestrial orchids (Platanthera chlorantha, Epipactis helleborine, E. neglecta and the mycoheterotrophic Neottia nidus-avis). All investigated species were mycorrhizal generalists (i.e., associated with a large number of fungi simultaneously), but mycorrhizal communities differed significantly between species. Mycorrhizal communities associating with the two Epipactis species consisted of a wide range of fungi belonging to different families, whereas P. chlorantha and N. nidus-avis associated mainly with Ceratobasidiaceae and Sebacinaceae species, respectively. Isotopic signatures differed significantly between both Epipactis species, with E. helleborine showing near autotrophic behavior and E. neglecta showing significant enrichment in both carbon and nitrogen. No significant differences in photosynthesis and stomatal conductance were observed between the two partially mycoheterotrophic orchids, despite significant differences in isotopic signatures. Our results demonstrate that partially mycoheterotrophic orchids of the genus Epipactis formed mycorrhizas with a wide diversity of fungi from different fungal families, but variation in mycorrhizal community composition was not related to isotope signatures and thus transfer of C and N to the plant. We conclude that the observed differences in isotope signatures between E. helleborine and E. neglecta cannot solely be explained by differences in mycorrhizal communities, but most likely reflect a combination of inherent physiological differences and differences in mycorrhizal communities.
Multivariate Identification of Functional Neural Networks Underpinning Humorous Movie Viewing
Authors: Lin Fa-Hsuan , Lee Hsin-Ju , Kuo Wen-Jui , Jääskeläinen Iiro P.
Published: February 2021

While univariate functional magnetic resonance imaging (fMRI) data analysis methods have been utilized successfully to map brain areas associated with cognitive and emotional functions during viewing of naturalistic stimuli such as movies, multivariate methods might provide the means to study how brain structures act in concert as networks during free viewing of movie clips. Here, to achieve this, we generalized the partial least squares (PLS) analysis, based on correlations between voxels, experimental conditions, and behavioral measures, to identify large-scale neuronal networks activated during the first time and repeated watching of three ∼5-min comedy clips. We identified networks that were similarly activated across subjects during free viewing of the movies, including the ones associated with self-rated experienced humorousness that were composed of the frontal, parietal, and temporal areas acting in concert. In conclusion, the PLS method seems to be well suited for the joint analysis of multi-subject neuroimaging and behavioral data to quantify a functionally relevant brain network activity without the need for explicit temporal models.
The Effect of Rhythmic Tactile Stimuli Under the Voluntary Movement on Audio-Tactile Temporal Order Judgement
Authors: Tanaka Taeko , Ogata Taiki , Miyake Yoshihiro
Published: February 2021

The simultaneous perception of multimodal sensory information is important for effective reactions to the external environment. In relation to the effect on time perception, voluntary movement and rhythmic stimuli have already been identified in previous studies to be associated with improved accuracy of temporal order judgments (TOJs). Here, we examined whether the combination of voluntary movement and rhythmic stimuli improves the just noticeable difference (JND) in audio-tactile TOJ Tasks. Four different experimental conditions were studied, involving two types of movements (voluntary movement, involuntary movement) and two types of stimulus presentation (rhythmic, one-time only). In the voluntary movement condition (VM), after the auditory stimulus (cue sound) participants moved their right index finger voluntarily and naturally, while in the involuntary movement condition (IM), their right index finger was moved by the tactile device. The stimuli were provided in a rhythmic or one-time only manner by hitting inside the first joint of the participants' right index finger using a tactile device. Furthermore, in the rhythmical tactile (RT) conditions, tactile stimuli were presented rhythmically to the right index finger 5 times consecutively. On the other hand, in the one-time tactile (1T) conditions, tactile stimuli was presented one-time only to the right index finger. Participants made an order judgment for the fifth tactile stimuli and the first and only auditory stimuli. In our TOJ tasks, auditory-tactile stimulus pairs were presented to participants with varying stimulus-onset asynchronies (SOAs; intervals between the within-pair onsets of the auditory and tactile stimuli). For the two stimuli presented at a time that were shifted by the SOA, the participants were asked to judge which one was presented first, and they were given a two-choice answer. Using a non-parametric test, our results showed that voluntary movement and rhythmic tactile stimuli were both effective in improving the JNDs in TOJ Tasks. However, in the combination of voluntary movement and rhythmic tactile stimuli, we found that there was no significant difference in JNDs in our experiments.
Creative Lockdown? A Daily Diary Study of Creative Activity During Pandemics
Authors: Karwowski Maciej , Zielińska Aleksandra , Jankowska Dorota M. , Strutyńska Elzbieta , Omelańczuk Iwona , Lebuda Izabela
Published: February 2021

The coronavirus disease 2019 (COVID-19) pandemic is influencing our lives in an enormous and unprecedented way. Here, we explore COVID-19-lockdown's consequences for creative activity. To this end, we relied on two extensive diary studies. The first, held on March 2019 (pre-pandemic), involved 78 students who reported their emotions and creativity over 2 weeks (927 observations). The second, conducted on March 2020 (during the pandemic and lockdown), involved 235 students who reported on their emotions, creativity, and the intensity of thinking and talking about COVID-19 over a month (5,904 observations). We found that compared with 2019, during the lockdown, students engaged slightly yet statistically significantly more in creative activities. An analysis of diaries collected during the pandemic also showed that the days when students spent more time discussing or searching for information about COVID-19 were characterized by a higher creative activity yet also mixed emotions. We discuss potential explanations of these unexpected results along with future study directions.
Classroom Interventions and Foreign Language Anxiety: A Systematic Review With Narrative Approach
Authors: Toyama Michiko , Yamazaki Yoshitaka
Published: February 2021

Experimental studies have developed, conducted, and evaluated classroom interventions for foreign language anxiety (FLA) reduction. However, various characteristics of those classroom interventions make it difficult to synthesize the findings and apply them to practice. We conducted what is, to the best of our knowledge, the first systematic review on educational interventions for FLA. Six criteria were established for inclusion of studies. Using English keywords, we identified 854 potentially eligible studies through ProQuest and Scopus, 40 of which were finally included. All included studies were published from 2007 to 2020. The studies differed in type of intervention, duration of intervention, and scale to measure FLA. Our systematic review resulted in seven features of classroom interventions, categorized as student–student interactions, student-teacher interactions, self-management, and mood boosters; we also categorized interventions as either individual or interactional.
Impact of Pre-Transplantation Psychological Counseling in Improving the Mental Well-Being of Patients on Hemodialysis
Authors: Zhao Qianyun , Zhang Sen , Yu Ran
Published: February 2021

Background: Patients who are on hemodialysis (HD) and are waiting for kidney transplantation encounter various psychological issues.

Objective: The current research aimed to compare the effectiveness of regular nursing care with that of nursing care coupled with dedicated psychological counseling in patients who were on HD before they underwent kidney transplantation.

Methods: Baseline data were collected 1 month before kidney transplantation in patients of both the control (patients who received general nursing care between August 2011 and June 2015) and intervention (patients who received nursing care and psychological counseling between June 2015 and July 2018) groups. The Mental Status Scale in Non-Psychiatric Settings (MSSNS) was administered to assess and record the psychological status. Clinicodemographic and end-stage renal disease (ESRD)-related details, including duration of dialysis, causes for ESRD, the number of dialysis sessions performed before transplantation, and MSSNS scores, were recorded and compared between the groups.

Results: A total of 37 patients were enrolled, including 19 in the control group and 18 in the intervention group. The number of dialysis sessions performed before transplantation was 143 (26, 564) and 227.5 (39, 767), and dialysis duration was 20.4 ± 14.5 and 14.4 ± 12.1 months in the intervention and control groups, respectively. There was no significant difference in baseline negative emotions between the two groups (P > 0.05). The psychological intervention group reported significantly lower anxiety, depression, anger, and loneliness scores than the control group (P < 0.05).

Conclusion: Psychological counseling before kidney transplantation in patients on HD could reduce their negative emotions and enhance mental well-being.
An Affective-Appraisal Approach for Parental Shared Decision Making in Children and Young People's Mental Health Settings: A Qualitative Study
Authors: Liverpool Shaun , Hayes Daniel , Edbrooke-Childs Julian
Published: February 2021

Background: The majority of existing shared decision making (SDM) models are yet to explicitly account for emotion as an influencing factor to the SDM process. This study aimed to explore the role of parents' and carers' emotional experiences as a concept that has implications for SDM in children and young people's mental health (CYPMH) settings.

Methods: A social constructivist grounded theory approach, analyzing data from focus groups (n = 4) and semi-structured interviews (n = 33) with parents and healthcare professionals, was undertaken. Participants were identified and selected at CYPMH sites and through social media platforms or in-person advertising as part of a larger feasibility trial. Interviews and focus groups were audio-recorded and transcribed verbatim. Thematic analysis moved from open to focused coding.

Results: The majority of the sample consisted of mothers of adolescent girls. Healthcare professionals had an average of 7.54 (SD = 6.24) years of work experience in CYPMH outpatient capacities. Findings suggested that parents are “expected to, but not always able to” engage in SDM. Themes and subthemes described an affective-appraisal SDM process capturing: (1) views and experiences of SDM, (2) parents' emotional states, (3) the influence of emotions on SDM, and (4) key support systems accessed. The emerging affective-appraisal framework highlighted that negative emotional states hindered parents' active involvement in SDM, and positive emotions encouraged involvement in SDM.

Conclusion: The current findings describe an SDM model specific to CYPMH. This new understanding contributes to addressing a possible theory to practice gap opening new challenges and opportunities for academic enquiry.
Avatar Embodiment. A Standardized Questionnaire
Authors: Peck Tabitha C. , Gonzalez-Franco Mar
Published: February 2021

The aim of this paper is to further the understanding of embodiment by 1) analytically determining the components defining embodiment, 2) increasing comparability and standardization of the measurement of embodiment across experiments by providing a universal embodiment questionnaire that is validated and reliable, and 3) motivating researchers to use a standardized questionnaire. In this paper we validate numerically and refine our previously proposed Embodiment Questionnaire. We collected data from nine experiments, with over 400 questionnaires, that used all or part of the original embodiment 25-item questionnaire. Analysis was performed to eliminate non-universal questions, redundant questions, and questions that were not strongly correlated with other questions. We further numerically categorized and weighted sub-scales and determined that embodiment is comprised of interrelated categories of Appearance, Response, Ownership, and Multi-Sensory. The final questionnaire consists of 16 questions and four interrelated sub-scales with high reliability within each sub-scale, Chronbach’s α ranged from 0.72 to 0.82. Results of the original and refined questionnaire are compared over all nine experiments and in detail for three of the experiments. The updated questionnaire produced a wider range of embodiment scores compared to the original questionnaire, was able to detect the presence of a self-avatar, and was able to discern that participants over 30 years of age have significantly lower embodiment scores compared to participants under 30 years of age. Removed questions and further research of interest to the community are discussed.
Assessment of the Ecological Health of Afrotropical Rivers Using Fish Assemblages: A Case Study of Selected Rivers in the Lake Victoria Basin, Kenya
Authors: Achieng Alfred O. , Masese Frank O. , Coffey Tracey J. , Raburu Phillip O. , Agembe Simon W. , Febria Catherine M. , Kaunda-Arara Boaz
Published: February 2021

Streams and rivers are globally threatened ecosystems because of increasing levels of exploitation, habitat degradation and other anthropogenic pressures. In the Lake Victoria Basin (LVB) in East Africa, these threats are mostly caused by unsustainable land use; however, the monitoring of ecological integrity of river systems has been hampered by a lack of locally developed indices. This study assessed the health of four rivers (Nzoia, Nyando, Sondu–Miriu and Mara) on the Kenyan side of the LVB using physicochemical water quality parameters and a fish-based index of biotic integrity (IBI). Fish tolerance ranking was derived from principal component analysis of water quality parameters, and the concept of niche breadth (NB). The relationship between fish species and water quality parameters was examined with canonical correspondence analysis, whereas community metrics and stressors were evaluated through Pearson network correlation analysis. Fish species richness, trophic structures, taxonomic composition and species tolerance were used to generate the metrics for fish-based IBI. NB showed that most of the fish species were moderately tolerant to poor water. Moderately tolerant and intolerant fish species were negatively correlated with a high level of organic loading in the Mara River. Fish-based IBI scores for the rivers ranged from 26 to 34, with Sondu–Miriu scoring the lowest. Our results show that the cumulative effect of stressors can adequately rank fish species tolerance according to the disturbance gradients and further develop regional metrics to assess river health. Despite the fact that fish communities are declining, continual management and enforcement of environmental regulations are important, with conservation and management of headwaters and low-order streams being essential while they are still species rich.
Simulated Dryland Cotton Yield Response to Selected Scenario Factors Associated With Soil Health
Authors: Ale Srinivasulu , Himanshu Sushil K. , Mauget Steven A. , Hudson Darren , Goebel Tim S. , Liu Bing , Baumhardt R. Louis , Bordovsky James P. , Brauer David K. , Lascano Robert J. , Gitz Dennis C.
Published: February 2021

In the Texas High Plains (THP), diminishing irrigation well-capacities, and increasing costs of energy and equipment associated with groundwater extraction and application are contributing factors to a transition from irrigated to dryland agriculture. The primary goal of this modeling exercise was to investigate whether and to what extent hypothetical changes in factors putatively associated with soil health would affect dryland cotton (Gossypium hirsutumL.) yields. The factors selected were drainage, surface runoff, soil water holding capacity, soil organic carbon (SOC) and albedo. As a first analysis to evaluate these factors, we used the CROPGRO-Cotton module within the Decision Support System for Agrotechnology Transfer (DSSAT) cropping system model. Specifically, we evaluated the effects of reduced surface runoff, increased soil water holding capacity, and SOC, doubling of the soil albedo through stubble mulching, and of soil drainage by enhancing infiltration with no-tillage/cover crops on yield by adjusting related soil properties. In our analysis, we used mean yields simulated with soil properties of a Pullman clay loam soil at Halfway, TX on the THP as baseline, which were compared to values obtained with the adjusted factors using weather data from 2005 to 2019. Simulated mean yield increased by 27% when the soil water holding capacity was increased by 25 mm, 7% when the runoff curve number was decreased from 73 to 60, 16% when soil albedo was increased from 0.2 to 0.4, and by 58% when the soil drainage factor (fraction day−1) was doubled from 0.2. No significant statistical change in simulated mean yield was calculated when SOC was increased by 1%. Further, effects of a 50 mm pre-plant irrigation were also assessed, simulating limited irrigation in the transition to dryland agriculture that resulted in a statistically insignificant 12% increase in seed-cotton yield. Simultaneous implementation of the four statistically significant individual scenarios (increased water holding capacity, infiltration, albedo, and drainage) resulted in the highest increase (93%) in mean seed-cotton yield. An economic and risk analysis of simulated yields under different scenarios indicated that these factors could reduce revenue risk for dryland cotton producers, with most of the effect from soil drainage improvements.
Towards Determining the Contrail Cirrus Efficacy
Authors: Ponater Michael , Bickel Marius , Bock Lisa , Burkhardt Ulrike
Published: February 2021

Contrail cirrus has been emphasized as the largest individual component of aircraft climate impact, yet respective assessments have been based mainly on conventional radiative forcing calculations. As demonstrated in previous research work, individual impact components can have different efficacies, i.e., their effectiveness to induce surface temperature changes may vary. Effective radiative forcing (ERF) has been proposed as a superior metric to compare individual impact contributions, as it may, to a considerable extent, include the effect of efficacy differences. Recent climate model simulations have provided a first estimate of contrail cirrus ERF, which turns out to be much smaller, by about 65%, than the conventional radiative forcing of contrail cirrus. The main reason for the reduction is that natural clouds exhibit a substantially lower radiative impact in the presence of contrail cirrus. Hence, the new result suggests a smaller role of contrail cirrus in the context of aviation climate impact (including proposed mitigation measures) than assumed so far. However, any conclusion in this respect should be drawn carefully as long as no direct simulations of the surface temperature response to contrail cirrus are available. Such simulations are needed in order to confirm the power of ERF for assessing contrail cirrus efficacy.
In-flight Lift and Drag Estimation of an Unmanned Propeller-Driven Aircraft
Authors: Bergmann Dominique , Denzel Jan , Pfeifle Ole , Notter Stefan , Fichter Walter , Strohmayer Andreas
Published: February 2021

The high-power density and good scaling properties of electric motors enable new propulsion arrangements and aircraft configurations. This results in distributed propulsion systems allowing to make use of aerodynamic interaction effects between individual propellers and the wing of the aircraft, improving flight performance and thus reducing in-flight emissions. In order to systematically analyze these effects, an unmanned research platform was designed and built at the University of Stuttgart. As the aircraft is being used as a testbed for various flight performance studies in the field of distributed electric propulsion, a methodology for precise identification of its performance characteristics is required. One of the main challenges is the determination of the total drag of the aircraft to be able to identify an exact drag and lift polar in flight. For this purpose, an on-board measurement system was developed which allows for precise determination of the thrust of the aircraft which equals the total aerodynamic drag in steady, horizontal flight. The system has been tested and validated in flight using the unmanned free-flight test platform. The article provides an overview of the measuring system installed, discusses its functionality and shows results of the flight tests carried out.
Estimation of Starch Hydrolysis in Sweet Potato (Beni Haruka) Based on Storage Period Using Nondestructive Near-Infrared Spectrometry
Authors: Kim Da-Song , Choi Moon-Hee , Shin Hyun-Jae
Published: February 2021

Sweet potatoes are a substantial source of nutrition and can be added to processed foods in the form of paste. The moisture and starch contents of these potatoes affect the physicochemical properties of sweet potato paste. In this study, the changes in the moisture, starch, and α-amylase content of sweet potatoes were measured for eight weeks after harvest. Using nondestructive near-infrared analyses and chemometric models, the moisture and starch contents were predicted. The partial least squares (PLS) method was used for prediction, while linear discriminant analysis (LDA) was used for discrimination. To increase the accuracy of the model, the near-infrared spectrum was preprocessed using the Savitzky–Golay derivative (S–G), standard normal variate (SNV), and multiplicative scattering correction methods. When applying PLS to the moisture content, the best calibration model accuracy was obtained using the S–G preprocessed spectrum. Furthermore, the best calibration model accuracy for starch content was obtained using the SNV preprocessed spectrum. The moisture and starch contents were categorized into five classes for LDA, with results indicating that the internal quality of sweet potatoes can be predicted and classified using chemometric models through nondestructive detection.
Application of Lateral Overturning and Backward Rollover Analysis in a Multi-Purpose Agricultural Machine Developed in South Korea
Authors: Hwang Seok-Joon , Jang Moon-Kyeong , Nam Ju-Seok
Published: February 2021

This study analyzed the lateral overturning and backward rollover characteristics of a multi-purpose agricultural machine recently developed in South Korea. Free body diagrams for theoretical analysis and a three-dimensional model for dynamic simulation were created by reflecting the actual dimensions and material properties of the multi-purpose agricultural machine. The simulation model was verified using the minimum turning radius and angle of static falling down sidelong derived through the certified performance test. The lateral overturning and backward rollover characteristics of the multi-purpose agricultural machine were analyzed using a verified simulation model and theoretical equations derived through literature review. In the lateral overturning analysis, the critical traveling speed at which lateral overturning occurs was derived according to the inner steering angle of the front wheels under steady-state turning conditions. In the backward rollover analysis, the critical angular velocity and theoretical traveling speed of the main body at which backward rollover occurs were derived according to lifting angle of the front wheels. There was no significant difference between the theoretical analysis and simulation results at 5% significance level, and we derived the appropriate traveling speed conditions of the multi-purpose agricultural machine that do not cause lateral overturning and backward rollover.
Time-Dependent Changes in the Physico-Chemical Parameters and Growth Responses of Sedum acre (L.) to Waste-Based Growing Substrates in Simulation Extensive Green Roof Experiment
Authors: Krawczyk Anna , Domagała-Świątkiewicz Iwona , Lis-Krzyścin Agnieszka
Published: February 2021

Over the last decade, an increase in the use of locally available, recycled, and waste materials as growing media components have occurred in various regions of the world in extensive green roof technology. For eco-concept reasons, such a strategy appears to be appropriate, but can be problematic due to difficulties in obtaining proper parameters of growing substrate. The growing media should be properly engineered in order to enable the proper functioning of green roofs and provide suitable environment for ideal root growth. The aim of the study was to assess the utility of locally occurring waste materials for growing media composition and estimate plant- and time-dependent changes in the physico-chemical parameters of waste-based substrates in a simulated extensive green roof system during a two-year Sedum acre L. cultivation. Five different substrate compositions were prepared using silica waste, crushed brick, Ca- and Zn-aggregates, melaphyre, tuff, sand, muck soil, urban compost, spent mushroom, and coconut fibres. Optimal water capacity, particle-size distribution, pH and salts concentration were found in all substrates. A higher concentration of macronutrients (N, P, K, Mg) and trace elements (B, Cu, Fe, Mn, Zn, Cd, Ni, Pb, and Cr) was found in waste-based substrates than in the commercial medium. In comparison to the parameters determined before establish the experiment, bulk density of tested growing media decreased, except for the substrates where the source of organic matter was the rapidly mineralising spent mushroom. The organic matter content in substrates after the two-year vegetation increased in relation to the ready-made substrate, with the exception of the composition with spent mushroom. After two years of the experiment, all available macronutrients and trace elements (with the exception of mineral N, K, SO4-S, and B) concentration were higher than in 2014, while pH, salt concentration was lower. In general, plants grown in waste substrates had lower dry matter content and higher biomass. A significantly higher biomass of S. acre L. was found in the first year of the experiment. In the second year of the research, the plants grown in the commercial medium, the substrate with silica waste, and the substrate with spent mushroom produced higher biomass than in the first year. No symptoms of abnormal growth were observed, despite the higher trace element concentrations in plants collected from waste-based substrate. Waste-based growing media can be considered as a valuable root environment for S. acre L. in an extensive green roof system.
Selenium and Dogs: A Systematic Review
Authors: Zentrichová Viola , Pechová Alena , Kovaříková Simona
Published: February 2021

The intent of this review is to summarize the knowledge about selenium and its function in a dog’s body. For this purpose, systematic literature search was conducted. For mammals, including dogs, a balanced diet and sufficient intake of selenium are important for correct function of metabolism. As for selenium poisoning, there are no naturally occurring cases known. Nowadays, we do not encounter clinical signs of its deficiency either, but it can be subclinical. For now, the most reliable method of assessing selenium status of a dog is measuring serum or plasma levels. Levels in full blood can be measured too, but there are no reference values. The use of glutathione peroxidase as an indirect assay is questionable in canines. Commercial dog food manufactures follow recommendations for minimal and maximal selenium levels and so dogs fed commercial diets should have balanced intake of selenium. For dogs fed home-made diets, complex data are missing. However, subclinical deficiency seems to affect, for example, male fertility or recovery from parasitical diseases. Very interesting is the role of selenium in prevention and treatment of cancer.