bluuebunny/crossref_metadata_2025 huggingface dataset:
Improved P&O-MPPT strategy based on new design of small-signal model used for voltage regulation of solar
Authors: Bechouat Mohcene , Sedraoui Moussa , Doghmane Hakim , Bourouba Houcine , Amieur Toufik , Sofiane Gherbi
Published: August 2023

This paper proposes a new design of small-signal model, used in the voltage loop of a solar system. The internal functioning of this system is considered fully unknown at standard test condition (STC) where a corresponding model is completely unavailable. The main idea consists on considering the nonlinear solar system behavior as a black box and only corresponding input-output samples are previously recorded by user. These samples are employed to estimate the parameters of a desired linear small-signal model, in which a first Graphical User Interface (GUI) of Matlab®/Identification/Toolbox™ is used. As the step-procedure needed to design this model type has never been addressed in any previous work, it will highlight therefore the key contribution of this paper. Subsequently, the resulting previous model is then used to synthesize a voltage PID controller where their parameters are tuned using guidelines, available in a second GUI of Matlab®/Control/Toolbox™. It allows overcoming perfectly the inherent ripple problems of standard the maximum power point tracking (MPPT) strategy utilizing the direct implementation of the perturb and observe (P&O) algorithm. As the combination of previous strategy with the synthetized voltage PID controller highlights the improved P&O-MPPT strategy. Indeed, the performances of both standard and improved P&O-MPPT strategies are compared where the simulation results prove the superiority of the improved P&O-MPPT control strategy over the standard one in terms of trade-off between the MPP tracking in steady state and the MPP speed convergence in transient state where any existing ripple problems are completely solved.
Investigation into Common Gene Signatures and Molecular Mechanisms Linking Aortic Dissection and Arteriosclerosis
Authors: Li Changying , Ran Haoyu , Luo Jun , Zhang Cheng , Wu Qingchen , Shao Yue , Shi Haoming
Published: August 2023

Aortic Dissection is a life-threatening vascular condition that occurs suddenly and is linked to various diseases. The primary objective of this research is to examine the overlapping genes and plausible molecular mechanisms associated with both aortic dissection and arteriosclerosis. From the GEO database, we obtained expression chip data GSE52093 and GSE28829, which are associated with aortic dissection (AD) and atherosclerosis (AS). By employing analysis of differential gene expression, we were able to identify the genes that are commonly shared by both diseases. Afterward, we utilized a PPI network and conducted a Cytoscape analysis, resulting in the identification of 9 central genes. Additionally, we performed a module-trait analysis using the GSE52093 and GSE28829 datasets, employing the WGCNA method, which led to the discovery of crucial genes linked to both conditions. The accuracy of the findings was confirmed through the utilization of independent datasets and real-time quantitative fluorescence PCR. Through PPI and WGCNA analysis of expression chip data GSE52093 and GSE28829 of AD and AS, we finally determined CNN1 and MYO1F as intersection genes. In RT-qPCR validation, the expression of CNN1 was consistent with our analysis results. Surprisingly, the expression of MYO1F did not show any statistically significant difference. However, the single-gene GSEA enrichment analysis revealed a noteworthy finding: CNN1 was significantly enriched in the CYTOSOLIC_DNA_SENSING_PATHWAY pathway for both AD and AS. Through this research, we have identified promising biomarker genes that are linked to both AD and AS diseases. Additionally, we have uncovered intricate molecular mechanisms and pathways associated with these conditions. These findings offer novel perspectives for advancing research and treatment approaches for both diseases.
Explainable Active Learning for Preference Elicitation
Authors: Cantürk Furkan , Aydoğan Reyhan
Published: August 2023

Gaining insights into the preferences of new users and subsequently personalizing recommendations necessitate managing user interactions intelligently, namely, posing pertinent questions to elicit valuable information effectively. In this study, our focus is on a specific scenario of the cold-start problem, where the recommendation system lacks adequate user presence or access to other users' data is restricted, obstructing employing user profiling methods utilizing existing data in the system. We employ Active Learning (AL) to solve the addressed problem with the objective of maximizing information acquisition with minimal user effort. AL operates for selecting informative data from a large unlabeled set to inquire an oracle to label them and eventually updating a machine learning (ML) model. We operate AL in an integrated process of unsupervised, semi-supervised, and supervised ML within an explanatory preference elicitation process. It harvests user feedback (given for the system's explanations on the presented items) over informative samples to update an underlying ML model estimating user preferences. The designed user interaction facilitates personalizing the system by incorporating user feedback into the ML model and also enhances user trust by refining the system's explanations on recommendations. We implement the proposed preference elicitation methodology for food recommendation. We conducted human experiments to assess its efficacy in the short term and also experimented with several AL strategies over synthetic user profiles that we created for two food datasets, aiming for long-term performance analysis. The experimental results demonstrate the efficiency of the proposed preference elicitation with limited user-labeled data while also enhancing user trust through accurate explanations.
Siamese tracking network with multi-attention mechanism
Authors: Xu Yuzhuo , Li Ting , Zhu Bing , Wang Fasheng , Sun Fuming
Published: August 2023

Object trackers based on Siamese networks view tracking as a similarity-matching process. However, the correlation operation operates as a local linear matching process, limiting the tracker's ability to capture the intricate nonlinear relationship between the template and search region branches. Moreover, most trackers don't update the template, and often use the first frame of an image as the initial template, which will easily lead to poor tracking performance of the algorithm when facing instances of deformation, scale variation and occlusion of the tracking target. To this end, we propose a Simases tracking network with multi-attention mechanism, including a template branch and a search branch. To adapt to changes in target appearance, we integrate dynamic templates and multi-attention mechanism in the template branch to obtain more effective feature representation by fusing the features of initial templates and dynamic templates. To enhance the robustness of the tracking model, we utilize a multi-attention mechanism in the search branch that shares weights with the template branch to obtain multi-scale feature representation by fusing search region features at different scales. In addition, we design a lightweight and simple feature fusion mechanism, in which the Transformer encoder structure is utilized to fuse the information of the template area and search area, and the dynamic template is updated online based on confidence. Experimental results on publicly tracking datasets show that the proposed method achieves competitive results compared to several state-of-the-art trackers.
Health Professionals’ Experience and Perceived Obstacles with Managing Patients’ Medication Information in Norway: Cross-Sectional Survey
Authors: Wang Bo , Manskow Unn Sollid
Published: August 2023

BackgroundAccess to correct and up to date medication information is crucial for effective patient treatment. However, persistent discrepancies exist. This study examines the experiences and challenges health professionals encounter while utilizing current digital solutions in the Norwegian healthcare system to manage patients' medication information.MethodsA cross-sectional descriptive analysis using quantitative survey data was conducted to investigate how health professionals managed patients’ medication information. Content analysis was used to analyze free-text responses concerning challenges they encountered when transferring medication information and to identify factors deemed necessary for implementing the shared medication list in Norway.ResultsA higher percentage of doctors (72.2%) expressed concerns regarding obtaining accurate and updated medication lists than nurses (42.9%), particularly for patients with polypharmacy (35.3%) or transitioning between primary and specialist care services (27.6%). The patient's verbal information was the main source for hospital doctors (17%) to obtain an overview of the patient’s medication usage, while general practitioners (19%) and nurses (working in both primary and specialist care services, 28% and 27% respectively) predominantly relied on electronic prescriptions. Doctors, in particular general practitioners, reported carrying excessive responsibilities in coordinating with other health actors (84.8%) and managing patients' medication information. The vast majority of doctors (84.4%) and nurses (82.0%) supported the idea of a shared medication list but desired a more equitable distribution of responsibility for updating and managing patients' medication information (doctors: 36.3%, nurses: 29.8%), while ensuring compatibility with existing digital systems (doctors: 31.5%, nurses: 8.5%).ConclusionsFragmented resources for medication information and unclear responsibilities were prevalent concerns among both professional groups. Doctors voiced more concern than nurses about the accuracy of patients’ medication list. While both groups are positive about a shared medication list, successful implementation requires proactive training initiatives, a clearer role clarification, and engaging patients for ensuring correct and up to date medication list, as well as safer patient management. Trail registration: Not applicable.
Satisfação acadêmica de estudantes universitários durante o ensino remoto emergencial
Authors: Pinto Izabel Cavalcanti Barros Lamenha , Coutinho Maria da Penha de Lima , Costa Filho Jairton da , Oliveira Erik Francisco Silva de , Pereira Sobrinho Emanuelle , Coutinho Márcio de Lima
Published: August 2023

O presente estudo teve como objetivo mensurar a satisfação de alunos universitários durante a experiência com o ensino remoto emergencial, bem como comparar o nível de satisfação em relação à percepção do ambiente pedagógico, à percepção afetiva, à percepção do ambiente físico, bem como à percepção da autoestima, por meio da Escala de Satisfação Acadêmica de Universitários. Foram estudados 208 estudantes de instituições de ensino superior privadas no Estado da Paraíba, Nordeste do Brasil. Os resultados revelaram um equilíbrio entre os escores gerais de satisfação e insatisfação entre os estudantes. Os menores níveis de insatisfação estiveram relacionados às percepções do ambiente pedagógico, as afetivas e da autoestima. Os níveis mais altos foram identificados na percepção do ambiente físico. Recomenda-se no futuro, que instituições de ensino superior de educação, considerem os incidentes insatisfatórios, para melhorar o processo educacional, quando porventura, adotarem em seus programas metodologias online ou híbridas.
Análise física e química da água do Córrego do Sabão, Município de Passos, Minas Gerais, Brasil
Authors: Souza Guilherme Silva de , Soares Pedro Augusto , Magri Rômulo Amaral Faustino
Published: August 2023

A água é um recurso indispensavel para sobrevivencia dos seres vivos, analisar a qualidade dela é de grande importância para melhores planejamentos da gestão dos recursos hídricos. O trabalho proposto teve como objetivo realizar análises físicas e químicas laboratoriais de dois pontos do Córrego do Sabão, localizado no Município de Passos, no sul do Estado de Minas Gerais, para comparar os parâmetros encontrados com a Resolução CONAMA nº 357/2005, para os rios Classe II. Foram analisados a turbidez, a cor, o oxigênio dissolvido, o pH, a alcalinidade, o gás carbônico e a temperatura. Para identificar possíveis alterações antrópicas e interferências do meio físico nas amostras, foram utilizadas tabelas in situ de Protocolo de Avaliação Rápida de Rios Urbanos, onde foram observados o tipo de vegetação, a presença de animais, o odor da água, entre outros parâmetros. O Córrego do Sabão é conhecido pela sua grande extensão geográfica dentro do perímetro do município. Os resultados mostrara-se satisfatórios, a água captada no ponto 2 necessita de apenas um tratamento simplicado para ser consumida.
Stress, a brief update.
Authors: Valencia-Florez Kenji Baruch , Sanchez-Castillo Hugo , Vázquez Priscila , Zarate Pavel , Berenice Paz Diana
Published: August 2023

Stress is fundamental for health and adaptation; it is an evolutionarily conserved response that involves several systems in the organism. The study of the stress response could be traced back to the end of the nineteenth century with George Beard’s or Claude Bernard’s work and,from that moment on, several studies that have allowed the elucidation of its neurobiology and the consequences of suffering from it were consolidated. In this theoretical review, we discuss the most relevant researches to our knowledge on the study of stress response, from theconcept of stress, its neurobiology, the hormonal response during stress, as well as its regulation, the effects of acute and chronic stress, stress from cognition, the different stress responses during life, as well as its relationship with different psychiatric disorders. Taken together, thereviewed research updates the classic perspective on stress, increasing the factors that should be considered in research to explore the effects of stress on health.
Impact of job mismatches on job satisfaction and turnover intention: Case of Russia
Authors:   Graduate School of Business, HSE University, Varshavskaya Elena Ya. , Podverbnykh Ulyana S. ,   Graduate School of Business, HSE University
Published: August 2023

Goal: to analyze the impact of different job mismatches (education, skill and horizontal), considered both individually and in various combinations with each other, on the job satisfaction and the turnover intention regarding the Russian case. Methodology: the research method is based on the identification of eight mutually exclusive groups, that differ in the combination of three types of job matches — from the full matched ones to the triple mismatched. Findings: all types of mismatches had a negative impact on satisfaction with nonmonetary labor characteristics. The most obvious negative relationship was found with professional satisfaction and moral satisfaction. Pay satisfaction is not influenced by overeducation and by the horizontal mismatch but it has been reduced by overskilling, separately or jointly with the two other types of mismatches. All kinds of mismatches (with the exception of a horizontal one) increase the probability of finding a job. Originality and contribution of the authors: the paper focuses on the combination of the three forms of mismatches and a multidimensional measure of job satisfaction. Such an approach made it possible to distinguish more effectively what facets of job satisfaction have been more influenced by mismatches. Furthermore, the paper increases understanding of the impact of job mismatches on non-monetary labor market outcomes. The results suggest that the focus of the HR firm policy should be placed on employees, who feel their skills are underutilized.
Artificial neural networks for performance prediction of full-scale wastewater treatment plants: a systematic review
Authors: Dantas Marina Salim , Christofaro Cristiano , Oliveira Sílvia Corrêa
Published: August 2023

Wastewater treatment plants (WWTPs) are complex systems that must maintain high levels of performance to achieve adequate effluent quality to protect the environment and public health. Artificial intelligence and machine learning methods have gained attention in recent years for modeling complex problems, such as wastewater treatment. Although artificial neural networks (ANNs) have been identified as the most common of these methods, no study has investigated the development and configuration of these models. We conducted a systematic literature review on the use of ANNs to predict the effluent quality and removal efficiencies of full-scale WWTPs. Three databases were searched, and 44 records of the 667 identified were selected based on the eligibility criteria. The data extracted from the papers showed that the majority of studies used the feedforward neural network model with a backpropagation training algorithm to predict the effluent quality of plants, particularly in terms of organic matter indicators. The findings of this research may help in the search for an optimum design modeling process for future studies of similar prediction problems.
Intercellular Interactions Mediated by HGF And TGF-Β Promote the 3D
Spherical and Xenograft Growth of Liver Cancer Cells
Authors: Peng Zheng , Lv Xiaolan , Zhang Pengfei , Chen Qiao , Zhang Hongyu , Chen Jianlin , Ma Xingxuan , Ouyang Bohui , Hao Meng , Tong Haibo , Guo Dongwei , Luo Yi , Huang Shigao
Published: August 2023

Background:

Recently, the importance of the interactions between liver cancer cells and
fibroblasts has been increasingly recognized; however, many details remain to be explored

Methods:

In this work, we first studied their intercellular interactions using conditioned medium
from mouse embryonic fibroblasts (MEFs), then through a previously established coculture model.

Results:

Culturing in a conditioned medium from MEFs could significantly increase the growth,
migration, and invasion of liver cancer cells. The coculture model further demonstrated that a positive
feedback loop was formed between transforming growth factor-β (TGF-β) from HepG2 cells
and mHGF (mouse hepatocyte growth factor) from MEFs during coculture. In this feedback loop,
c-Met expression in HepG2 cells was significantly increased, and its downstream signaling pathways,
such as Src/FAK, PI3K/AKT, and RAF/MEK/ERK, were activated. Moreover, the proportion
of activated MEFs was also increased. More importantly, the growth-promoting effects caused
by the interaction of these two cell types were validated in vitro by a 3D spheroid growth assay and
in vivo by a xenograft mouse model.

Conclusion:

Collectively, these findings provide valuable insights into the interactions between fibroblasts
and liver cancer cells, which may have therapeutic implications for the treatment of liver
cancer
Research Progress of Tamarixetin and its Glycosides
Authors: Li Cunbing , Tao Mengxin , Li Tingting , Huang Xiaofen , Sui Hong , Fu Xueyan
Published: August 2023

Tamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, antiinflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1976 to 2023 are obtained from PubMed, China Knowledge Base Database, Wanfang Data, and other electronic databases. Tamarixetin is searched based on keywords, and 121 articles remain. Transformation synthesis, pharmacokinetics, pharmacological action, and structureactivity relationship of tamarixetin were reviewed.
WITHDRAWN: Comprehensive Analysis of the Role of CXCL Family Members in Clear Cell Renal Cell Carcinoma
Authors: Qiu Jiechuan , Wang Zicheng , Zhang Peizhi , Xu Yingkun , Yang Tianmin , Xia Qinghua
Published: August 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the journal Current Cancer Drug Targets.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:
It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultane-ously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Identification of the Near Full-length Genome of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant with a Complex Genomic Structure Isolated in Hebei Province, China
Authors: Fan Weiguang , Jia Jianru , Shi Haoxi , Su Miaomiao , Meng Juan , An Weina
Published: August 2023

Background:

During HIV genotypic drug resistance testing of patient samples in Baoding,
Hebei Province, China, in 2022, a recombinant fragment was detected in the pol region of an
HIV-1 strain.

Objective:

The objective of the study was to analyze the near full-length genome of a novel HIV-1
CRF01_AE/CRF07_BC recombinant with a complex genomic structure.

Methods:

Viral RNA was extracted from the blood of the infected individual and reverse transcribed
to cDNA. Two overlapping segments of the HIV-1 genome were amplified using a nearendpoint
dilution method and sequenced. Recombinant breakpoints were determined using RIP,
jpHMM, and SimPlot 3.5.1 software. MEGA 6.0 software was used to construct a neighbor-joining
phylogenetic tree.

Results:

We obtained the near full-length genome sequence (8680 bp) of a novel HIV-1
CRF01_AE/CRF07_BC recombinant. Recombination analysis showed that the genome comprised
at least 12 overlapping segments, including six CRF07_BC and six CRF01_AE segments, with
CRF07_BC as the backbone. The emergence of CRF01_AE/CRF07_BC recombinant strains indicated
that HIV-1 co-infection is common. However, the increasing genetic complexity of the HIV-1
epidemic in China warrants continued investigation.

Conclusion:

The increase in CRF01_AE/CRF07_BC recombinant viruses suggests that HIV-1 has
a high genetic mutation rate in Hebei, China. This highlights the need for close monitoring of HIV-1
molecular epidemiologic changes to provide accurate, up-to-date information for effective disease
control.
A Recent Update on the Visible Light-promoted Organic Transformations -
A Mini-review
Authors: Dinodia Monica
Published: August 2023

Visible light-induced reactions are a rapidly developing and powerful technique to pro-mote organic transformations. They provide green and sustainable chemistry and have recently re-ceived increasing attention from chemists due to their wide application in organic synthesis. Light energy is eco-friendly, cheap, green, and inexhaustible with potential industrial and pharmaceutical applications. In this review, the most recent advances in visible light-induced reactions (2021-till date) have been highlighted.
Design, Synthesis, Anti-inflammatory Evaluation and In silico Molecular Docking of Novel Furan-based Derivatives as Potential TNF-α Production Inhibitors
Authors: Bhoge Satish , Singh Prabal Pratap , Das Deepak , Ali Yakub , Dhulap Abhijeet
Published: August 2023

Introduction:

Inflammation is the first response and an alarming signal for the onset of chronic
disease. Most of the anti-inflammatory drugs available in the market are reported to have undesirable
gastrointestinal toxicities. Therefore, it is of urgent significance to develop anti-inflammatory drugs with
low toxicity and good efficacy.

Methods:

We created a targeted scaffold based on a literature review by combining the different structural
characteristics of furan and benzyl amides into a single pharmacophore. A series of eighteen furanbased
derivatives (1-18) were designed, synthesized for in vitro and in vivo anti-inflammatory activity.
The characterization of synthesized compounds was elucidated by techniques like 1H-NMR, 13C-NMR,
FT-IR and MS.

Results:

The synthetic compounds were examined through molecular docking studies on TNF-α for probable
binding mode and interactions with hydrophilic and hydrophobic pocket of TNF-α in comparison to
standard drug (Indomethacin).

Conclusion:

When compared to the standard treatment, compounds 18, 15 and 9 displayed a remarkable
inhibitory effect on the production of TNF-α and in vivo inflammatory activity with no damage to stomach
and reduction of LPO. The compounds 18, 15 and 9 might be a good consideration for potential antiinflammatory
agents.
Investigating the Synthesis Methods of 3,5-dione Pyrazolidine and 3,5-dione
1-phenylpyrazolidine in the Presence and Absence of Ultrasound Bath and
their Anticancer Effects on MCF-7 Breast Cancer Cells
Authors: Nadipour Fatemeh , Salahvarzi Sabah , Dadgar Zeynab
Published: August 2023

Background:

Pyrazolidine 5,3-dione derivatives have a wide range of biological and pharmacological activities and play an important role in the sub-structures of various drugs. They also have inhibitory and antimicrobial properties, anti-tumor, anti-inflammatory, analgesic, anti-tuberculosis, anti-hypertensive, anti-cancer, and anti-Alzheimer. The purpose of the current study was to investigate a number of synthesis methods of pyrazolidine-3,5-dione and 1 phenylpyrazolidine-3,5-dione in the presence and absence of ultrasound bath and their anti-cancer effects on mcf-7 breast cancer cells.

Methods:

In this study, pyrazolidine-3,5-dione and 1-phenylpyrazolidine-3,5-dione were synthesized using hydrazine, phenylhydrazine, and diethyl malonate by different methods. The advantage of this research compared to other studies is the use of different methods (3 methods and each method were performed in two different conditions, toalling 6 methods) for the synthesis of these two derivatives. The effect of two synthesized derivatives on MCF-7 cell line breast cancer cells was also investigated using MTT (methylthiazole tetrazolium) test. IR, 13CNMR, and HNMR spectroscopy methods have also been used to determine the structure of products.

Results:

The results of FT-IR and NMR spectrum analysis confirm the synthesized pyrazolidine-3,5-dione and 1-phenylpyrazolidine-3,5-dione. Based on the results in zero doses (control group) and 10 μM of all Samples after 24 hours, no significant difference in the number of cells was observed. However, the number of cells significantly decreased after treatment with 20 μM dose of both pyrazolidine-3,5-dione and 1-phenylpyrazolidine-3,5-dione. Also, there was no significant difference in reducing cancer cell proliferation between pyrazolidine-3,5-dione and 1-phenylpyrazolidine-3,5-dione samples. In addition, treatment of cancer cells with 40 μM of both hydrazine and phenylhydrazine samples after 24 hours caused approximately 50% cell death and reduced the number of cancer cells by approximately half compared to the control group.

Conclusion:

According to the results of this study, treatment of cancer cells with a dose of 40 μM in both samples of pyrazolidine-3,5-dione and 1-phenylpyrazolidine-3,5-dione after 24 hours caused cell death in approximately 50% of cells and the number of cancer cells is almost half that of the control group.
Hypothyroidism in Older Adults: A Narrative Review
Authors: Fiore Vincenzo , Barucca Alessandra , Barraco S. , Triggiani Domenico , Carbotta Giovanni , Giagulli Vito Angelo , Piazzolla Giuseppina , Lisco Giuseppe , Triggiani Vincenzo
Published: August 2023

Introduction:

The prevalence of hypothyroidism increases along with aging, resulting in
one of the most common comorbidities among patients over 75 years. The leading causes of hypothyroidism
in older adults are iatrogenic, Hashimoto's thyroiditis, and medications. The narrative review
aimed to discuss the clinical characteristics of hypothyroidism in older adults and the impact of hormonal
replacement therapy on survival rates. Thyroid function declines over time due to physiological
changes in the thyroid stimulating hormone signaling, iodine absorption and metabolism, thyroid hormone
metabolism, and activity at peripheral sites. A serum TSH value over the upper limit of the normal
reference range is not necessarily attributable to hypothyroidism. However, an appropriate diagnostic
work-up is required to rule out true hypothyroidism and discriminate the etiology (i.e., thyroid
autoimmune diseases, iodine deficiency, drug-induced hypothyroidism). Levothyroxine treatment
should be considered in cases of overt hypothyroidism. A complete risk-to-benefit assessment, particularly
considering the overall health status, life expectancy, cognitive function, mood, and cardiovascular
and neurological background, should be considered before treating subclinical hypothyroidism
with more potential benefits in patients under 75 years old. Levothyroxine formulations facilitating
hormone absorption and increasing compliance to long-term treatment should be preferred. TSH
target should usually be set over 3 mIU/ml. Defining optimal diagnostic approaches and targeted therapeutic
strategies should be considered in the personalized management of aged patients with hypothyroidism.

Results:

Thyroid function declines over time due to physiological changes in the thyroid stimulating hormone signaling, iodine absorption and metabolism, thyroid hormone metabolism, and activity at peripheral sites. A serum TSH value over the upper limit of the normal reference range is not necessarily attributable to hypothyroidism. However, an appropriate diagnostic work-up is required to rule out true hypothyroidism and discriminate the etiology (i.e., thyroid autoimmune diseases, iodine deficiency, drug-induced hypothyroidism). Levothyroxine treatment should be considered in cases of overt hypothyroidism. A complete risk-to-benefit assessment, particularly considering the overall health status, life expectancy, cognitive function, mood, and cardiovascular and neurological background, should be considered before treating subclinical hypothyroidism with more potential benefits in patients under 75 years old. Levothyroxine formulations facilitating hormone absorption and increasing compliance to long-term treatment should be preferred. TSH target should usually be set over 3 mIU/ml.
Does Vitamin E Supplementation Alter Hormonal Levels in Polycystic
Ovary Syndrome: A Systematic Review of Randomized Controlled Trials
Authors: Begum Rukaiah Fatma , Suresh Swathi , Devi V Sharmila , Moka Murali Krishna , Mohan Sumithra
Published: August 2023

Background:

Vitamin E influences hormonal parameters in women, but the evidence concerning its effectiveness in polycystic ovarian syndrome (PCOS) are constrained.

Objective:

The objective of this systematic review is to perceive the mechanism behind the hormonal effects of vitamin E in PCOS and explore the effectiveness of vitamin E by analyzing the clinical studies.

Methods:

Electronic bibliographic databases, such as PubMed, Scopus, ProQuest, DOAJ, ScienceDirect, and Cochrane Library, were searched for clinical studies scrutinizing the effect of vitamin E supplementation on PCOS. The systematic review protocol is registered in PROSPERO (CRD42021272963) and was performed as per the PRISMA guidelines. Records analyzing the hormonal parameters were included. For individual study, the risk of bias was ascertained with NHLBI protocol for controlled randomized studies.

Results:

There were 1438 records identified, of which seven records were retrieved which met the inclusion criteria. Bibliographic details, number of participants, the dose of vitamin E, duration of the treatment and trial, parameters analyzed, and outcome of each study were extracted comprehensively. In the review, the majority of the studies embraced high-quality studies, which included double-blinded controlled trials, open-label controlled studies, and cohort studies.

Conclusion:

Vitamin E implies having a progesterone-like impression with estrogenic and androgenic properties. Furthermore, the ability of vitamin E as an antioxidant is also advantageous in PCOS women. However, there is a lack of empirical evidence on its mechanism, and the inadequacy of large-scale concerns about different age groups against PCOS is requisite.
On the Formation of ‘rʌ’ Irregular: Focusing on the ‘Nirɨda/Nirɨlda’
Authors:   Korean Language & Literature, Hong Hee-jeong
Published: August 2023

This paper aims to study ‘rʌ(러)’ irregular of Modern Korean, which has gotten less attention than other irregular classes. The ‘rʌ’ irregular is a conjugation in which ‘irɨda(이르다), purɨda(푸르다), nurɨda(누르다)’ are combined with the vowel ending, which ‘r(ㄹ)’ is added, resulting in the conjugated forms that ‘irɨrʌ(이르러), purɨrʌ(푸르러), nurɨrʌ(누르러)’. The ‘rʌ’ irregular of Modern Korean is the irregular with different characteristics from ‘p(ㅂ)’ irregular and ‘s(ㅅ)’ irregular. Because the ‘rʌ’ irregular isn’t the irregular conjugation formed by phonological motivations such as the changes of phonetic value and phonological phenomena. However, there is a limit that cannot be specifically discussed the motivations of forming the ‘rʌ’ irregular in previous studies. Thus, this study discussed how the ‘rʌ’ irregular of Modern Korean was formed by which motivations and gone through which processes of diachronic changes. According to the data of Middle Korean, it can be seen that the ‘rʌ’ irregular was composed of only color-adjectives such as ‘pɨrɨda(프르다), nurɨda(누 르다)’ in the 15th century, and was added ‘nirɨda(니르다)’ the 16th century, finally formed. In addition, it could analyze that the ‘rʌ’ irregular was formed by the non-phonological motivation of the convergence between paradigms. As a result, it comes to have the possibilities to solve various problems related to the formation of ‘rʌ’ irregular.
Morphological and Molecular Characterization of Five Cultivars of Ziziphus
spp. Cultivated in Southern Iraq
Authors: Lafta Hzaa Ahmed Yousef , Malallah Alkanan Israa , Radhi Sahib Mohammad
Published: August 2023

Ziziphus spp. is one of the economic fruit trees whose cultivation spreads in
southern Iraq. This study characterized the morphological, molecular, and genetic
diversity of five cultivars (Malasy, Normal, Zaytony, Bambawi, Tofahy), using 12
morphological indicators for leaf and fruit and six primers for RAPD technology.
The results of the morphological characterization showed that the two cultivars
(Normal and Malasy) recorded the highest genetic kinship between them,
amounting to 10.04. In comparison, the farthest genetic distance between the two
cultivars (Zaytony and Normal) was recorded, which amounted to 29.3. As for the
molecular characterization results, the primers produced 113 20 bands, with an
average of 18.8 bands for each primer, and the percentage of polymorphism was
100% and unique bands totaling 51 bands appeared, including 17 bands with different molecular weights characteristic of the cultivars. The genetic tree diagram
showed the distribution of cultivars in two groups. The combination of morphological and molecular characterization is one of the most important tools that can
be relied upon in finding genetic differences and determining fingerprints, especially between types of genders or cultivars of the same species.
Keywords: fingerprints, genetic distance, Morphological, RAPD, Ziziphus.
Impacts of Ganoderma lucidum (Reishi mushroom) on the properties of electrospun
polymeric nanofibers
Authors: Abbass Kadham Dalal , Jabbar Braihi Auda , Jawad Kadham Hanaa
Published: August 2023

Three polymeric solutions, PVA, Collagen and Hyaluronic acid (HAc), were
prepared and mixed by (55:22.5:22.5) ratios to prepare the net polymeric solution. Also, Ganoderma lucidum (G. lucidum) solution was prepared and added to
the neat solution by three ratios (1wt%, 3wt% and 5wt%), which was then
pumped by electrospinning technique to create a nanofiber bead. Solutions results
showed that G. lucidum caused drag reduction, decreasing the viscosities, facilitating solution flow inside the needle and leading to the formation of fine nanofibers easily. Also, at low G. lucidum ratios, the electrostatic repulsion overcomes
the surface tension, which enables fibers to escape from the "Taylor cone" tip and
gather on the collector. As well as the electrical conductivity increased due to the
ease of movement of HAc ions due to viscosity reduction. FTIR results proved no
losses of any component of the net blend, and there is no chemical reaction
among them. Results of the obtained nanofiber showed that, with the G. lucidum
addition, there is an increment in fiber diameter, number of beads, the goodness
of orientation and surface roughness. G. lucidum also reduced the wettability, the
crystallinity and the enthalpy consumed during the thermal transition.
Keywords: Ganoderma lucidum, FESEM, Directionality Histogram,
Electrospinning, Wettability
Effect of treatment by nutrient solution (SiliKaSol) and irrigation with
magnetically treated water on some physical and chemical properties of tissue-grown short-stem banana plants in greenhouse conditions
Authors: H. Mohammed Khawla , A. Muhsen Khaun , A. Alwan Alyaa
Published: August 2023

This study was conducted at the Agricultural Research and Experiment Station,
College of Agriculture, Basra University, from 02.01.2018 to 30.06.2018 on the
Indian short-stemmed banana plant M.caredishii, multiplied by tissue in the tissue
culture laboratory of the Palm and Localized Research Center, at 6 months age.
They were grown in a greenhouse equipped with a desert cooling system. The
plants were sprayed with 5 concentrations of the nutrient solution SiliKaSol (0,
0.5, 1, 1.5, 2) ml l-1
and by 5 sprays between one spray and another 10 days starting
from 02.01.2018. These plants were irrigated during the study period by two types
of irrigation water: magnetically treated water and normal water. The most important results can be summarized as follows:- Spraying at a concentration of 2 ml
l
-1 of the nutrient solution showed a significant increase in the physical characteristics (increase in plant height and leaf area), reaching 32.33 cm and 312.83 cm2
,
respectively, and an increase in chemical properties (content of leaves from proline, total soluble carbohydrates, total chlorophyll and nitrogen percentage in the
leaves) reached 16.01 µg g-1
, 1.26 mg g-1
and 4.31 mg g-1
, respectively. The results
also showed that the quality of irrigation water had a positive effect on improving
most of the physical and chemical properties, as watering with magnetized water
achieved an increase in plant height, leaf area, and dry weight of the leaves by 3.07
cm, 290.33 cm, 13.46 g, and 1.56 g, respectively, and caused an increase in the
chemical properties of total soluble carbohydrates, total chlorophyll, and the percentage of NPK in leaves, which were 1.32 mg g-1
, 4.73 mg g-1
, 16.78%, and
1.32% and 20.39%, respectively.
Keywords: Banana, Water Magnatic, SiliKaSol, Nutrient solution.
Random amplified polymorphic DNA -RAPD analysis of human cervical
cancer in Samwha city
Authors: Abdulwahab Ati Al-Askeri Mohammed
Published: August 2023

Objectives: The study intended to distinguish a likely hereditary variety in the
genomic DNA of Iraqi patients corresponding with cervical disease and the possibility of getting an advantage of the potentially produced DNA fragment(s) as a
molecular test for future related applications. Methods: Blood and tissue tests
were collected from female patients with cervical malignant growth and solid
females; DNA was extricated and purged from each example, and then "Irregular
Amplification of Polymorphic DNA technique"(RAPD) was directed with oligonucleotide "OPA-20". Results: RAPD results examination with oligonucleotide
“OPA-20” could identify four polymorphic DNA groups in the genome of patients females, in which these bands were missing in the majority of genomic
DNA of healthy people.
Keywords: Tumor, PCR, Iraq, gene polymorphism
Mobile Phone Text Messages to Support People to Stop Smoking by Switching to Vaping: Codevelopment, Coproduction, and Initial Testing Study
Authors: Sideropoulos Vassilis , Vangeli Eleni , Naughton Felix , Cox Sharon , Frings Daniel , Notley Caitlin , Brown Jamie , Kimber Catherine , Dawkins Lynne
Published: August 2023

Background

SMS text messages are affordable, scalable, and effective smoking cessation interventions. However, there is little research on SMS text message interventions specifically designed to support people who smoke to quit by switching to vaping.

Objective

Over 3 phases, with vapers and smokers, we codeveloped and coproduced a mobile phone SMS text message program. The coproduction paradigm allowed us to collaborate with researchers and the community to develop a more relevant, acceptable, and equitable SMS text message program.

Methods

In phase 1, we engaged people who vape via Twitter and received 167 responses to our request to write SMS text messages for people who wish to quit smoking by switching to vaping. We screened, adjusted, refined, and themed the messages, resulting in a set of 95 that were mapped against the Capability, Opportunity, and Motivation–Behavior constructs. In phase 2, we evaluated the 95 messages from phase 1 via a web survey where participants (66/202, 32.7% woman) rated up to 20 messages on 7-point Likert scales on 9 constructs: being understandable, clear, believable, helpful, interesting, inoffensive, positive, and enthusiastic and how happy they would be to receive the messages. In phase 3, we implemented the final set of SMS text messages as part of a larger randomized optimization trial, in which 603 participants (mean age 38.33, SD 12.88 years; n=369, 61.2% woman) received SMS text message support and then rated their usefulness and frequency and provided free-text comments at the 12-week follow-up.

Results

For phase 2, means and SDs were calculated for each message across the 9 constructs. Those with means below the neutral anchor of 4 or with unfavorable comments were discussed with vapers and further refined or removed. This resulted in a final set of 78 that were mapped against early, mid-, or late stages of quitting to create an order for the messages. For phase 3, a total of 38.5% (232/603) of the participants provided ratings at the 12-week follow-up. In total, 69.8% (162/232) reported that the SMS text messages had been useful, and a significant association between quit rates and usefulness ratings was found (χ21=9.6; P=.002). A content analysis of free-text comments revealed that the 2 most common positive themes were helpful (13/47, 28%) and encouraging (6/47, 13%) and the 2 most common negative themes were too frequent (9/47, 19%) and annoying (4/47, 9%).

Conclusions

In this paper, we describe the initial coproduction and codevelopment of a set of SMS text messages to help smokers stop smoking by transitioning to vaping. We encourage researchers to use, further develop, and evaluate the set of SMS text messages and adapt it to target populations and relevant contexts.
Understanding Morning Emotions by Analyzing Daily Wake-Up Alarm Usage: Longitudinal Observational Study (Preprint)
Authors: Oh Kyue Taek , Ko Jisu , ­Jin Nayoung , Han Sangbin , Yoon Chan Yul , Shin Jaemyung , Ko Minsam
Published: August 2023

BACKGROUND

Morning emotions can significantly affect daily wellness. While many studies have analyzed daily survey responses to identify factors influencing morning emotions, these methods require additional time and effort from individuals for emotional monitoring.

OBJECTIVE

This study aims to identify daily alarm usage patterns related to morning emotions.

METHODS

We recruited 373 users of the Alarmy app (DelightRoom) in the United States and South Korea and surveyed their demographics and usual behaviors related to morning emotions. Participants described their morning emotions over a 2-week period, during which we collected daily alarm app logs. We used a generalized estimating equation (GEE) method to identify factors affecting morning emotions.

RESULTS

The findings indicate that varied alarm usage is related to morning emotions. Alarm set time was positively associated with feelings of peacefulness and refreshment in the morning, while task-based alarms were related to nervousness. The time taken to deactivate the alarm after it rang was negatively correlated with happiness. In addition, usual behaviors and demographic factors were found to be related to morning emotions, consistent with previous studies.

CONCLUSIONS

The study reveals that daily alarm usage is related to morning emotions, suggesting that daily alarm logs can supplement survey methods to facilitate daily emotion monitoring.
Design of Virtual Anchor Based on 3Dmax
Authors: Zixuan Wang , Mao Ye , Runze Xiang
Published: August 2023

With the rapid development of virtual reality and live streaming technologies, virtual anchors have become increasingly popular in recent years. In this paper, we propose a design method of virtual anchors based on 3DMAX. Through the use of modeling, rigging, and animation techniques, virtual anchors with realistic appearances and human-like movements can be created. We also explore the application of machine learning technologies in improving the interaction between virtual anchors and users. In addition, we provide a case study on the design and implementation of a virtual anchor for a popular live streaming platform. Our results show that the use of 3DMAX in virtual anchor design can greatly enhance user engagement and improve the overall user experience.Virtual anchor design technology based on 3DMAX is a highly complex design work, which requires designers to have a variety of skills and creative capabilities, and needs to fully consider the needs of the audience and the development trend of the industry. Designers should also have certain cultural accumulation and creative ability, and be able to design an attractive and valuable virtual anchor image from the perspective of the audience.This paper analyzes the production and design of the current virtual anchors, in order to provide some reference significance for the production, operation and commercial realization of the virtual anchors in the future.
AN ANALYSIS ON STUDENTS’ WRITING MOTIVATION AT SMKN 1 BANGKINANG
Authors:   Universitas Pahlawan Tuanku Tambusai, Yunanda Nurma , Asilestari Putri ,   Universitas Pahlawan Tuanku Tambusai, Hardi Vitri Anggraini ,   Universitas Pahlawan Tuanku Tambusai
Published: August 2023

This study aims to describe the problems in writing narrative text for class XI students of SMAN 1 Koto Kampar Hulu, describing the problems faced by students in write narrative texts, and provide solutions or ways to overcome problems faced by students. This study uses a qualitative description method. Technique data collection was obtained by using interview techniques and documentation, and the data obtained were analyzed using Triangulation data sources and method triangulation. The results showed that in writing narrative text, in class XI students of SMAN 1 Koto Kampar Hulu carried out based on 2013 curriculum, class XI English learning syllabus, and carried out according to the English lesson plan for narrative text teaching materials. The problems faced in writing narrative texts are: teacher teaching to students is not optimal, students' motivation is low in writing narrative text, How to overcome these difficulties is that teachers are given training and guidance regarding learning and students are given attention, motivation to be active in learning