bluuebunny/crossref_metadata_2025 huggingface dataset:
An ONIOM-Based High-Level Thermochemistry Study on Hydrogen Abstraction Reactions of Large Straight-Chain Alkanes by Hydrogen, Hydroxyl, and Hydroperoxyl Radicals
Authors: Chi Yicheng , Pan Hao , Meng Qinghui , Zhang Lidong , Zhang Peng
Published: March 2024

Accurate thermochemical data are of great importance in developing quantitatively predictive reaction mechanisms for transportation fuels, such as diesel and jet fuels, which are primarily composed of large hydrocarbon molecules, especially large straight-chain alkanes containing more than 10 carbon atoms. This paper presents an ONIOM[QCISD(T)/CBS:DFT]-based theoretical thermochemistry study on the hydrogen abstraction reactions of straight-chain alkanes, n-CnH2n+2, (n = 1–16) by hydrogen (H), hydroxyl (OH), and hydroperoxyl (HO2) radicals. These reactions, with n ≥ 10, pose significant computational challenges for prevalent high-level ab initio methods. However, they are effectively addressed using the ONIOM-based method. One notable aspect of this study is the consideration of the high symmetry of straight-chain alkanes. This symmetry allows us to study half of the reactions, employing a generalized approach. Therefore, a total of 216 reactions are systematically studied for the three reaction systems. Our results align very well with those from the widely accepted high-level QCISD(T)/CBS method, with discrepancies between the two generally less than 0.10 kcal/mol. Furthermore, we compared large straight-chain alkanes (n-C16H34 and n-C18H38) with large methyl ester molecules (C15H31COOCH3 and C17H33COOCH3) to elucidate the impact of functional groups (ester group and C=C double bond) on the reactivity of the long-chain structure. These findings underscore the accuracy and efficiency of the ONIOM-based method in computational thermochemistry, particularly for large straight-chain hydrocarbons in transportation fuels.
Botulinum Toxin for Pain Relief in Cancer Patients: A Systematic Review of Randomized Controlled Trials
Authors: Lippi Lorenzo , de Sire Alessandro , Turco Alessio , Ferrillo Martina , Kesikburun Serdar , Baricich Alessio , Carda Stefano , Invernizzi Marco
Published: March 2024

Cancer pain is one of the most disabling symptoms complained by cancer patients, with a crucial impact on physical and psychological well-being. Botulinum neurotoxins (BoNTs) type A and B have emerged as potential interventions for chronic pain; however, their role in these patients is still debated. Thus, this systematic review of randomized controlled trials aimed at assessing the effects of BoNT treatment for cancer pain to guide physicians in an evidence-based approach integrating BoNT in cancer care. Out of 5824 records, 10 RCTs satisfied our eligibility criteria and were included in the present work for a total of 413 subjects with several cancer types (breast, head and neck, esophageal, and thoracic/gastric cancers). While some studies demonstrated significant pain reduction and improved quality of life post-BoNT-A injections, outcomes across different cancer types were inconclusive. Additionally, several effects were observed in functioning, dysphagia, salivary outcomes, esophageal strictures, gastric emptying, and expansions. This review emphasizes the need for further standardized research to conclusively establish the efficacy of BoNT in comprehensive cancer pain management.
The Effects of T-2 Toxin, Deoxynivalenol, and Fumonisin B1 on Oxidative Stress-Related Genes in the Kidneys of Laying Hens
Authors: Kövesi Benjamin , Kulcsár Szabina , Ancsin Zsolt , Erdélyi Márta , Zándoki Erika , Gömbös Patrik , Balogh Krisztián , Mézes Miklós
Published: March 2024

In the context of nephrotoxic risks associated with environmental contaminants, this study focused on the impact of mycotoxin exposure on the renal health of laying hens, with particular attention to oxidative stress pathways. Sixty laying hens were assigned to three groups—a control group (CON), a low-dose mycotoxin group (LOW), and a high-dose mycotoxin group (HIGH)—and monitored for 72 h. Mycotoxin contamination involved T-2/HT-2 toxin, DON/3-AcDON/15-AcDON, and FB1 at their EU-recommended levels (low mix) and at double doses (high mix). Clinical assessments revealed no signs of toxicity or notable weight changes. Analysis of the glutathione redox system parameters demonstrated that the reduced glutathione content was lower than that in the controls at 48 h and higher at 72 h. Glutathione peroxidase activity increased in response to mycotoxin exposure. In addition, the gene expression patterns of key redox-sensitive pathways, including Keap1-Nrf2-ARE and the AhR pathway, were examined. Notably, gene expression profiles revealed dynamic responses to mycotoxin exposure over time, underscoring the intricate interplay of redox-related mechanisms in the kidney. This study sheds light on the early effects of mycotoxin mixtures on laying hens’ kidneys and their potential for oxidative stress.
The ASTRI Mini-Array: A New Pathfinder for Imaging Cherenkov Telescope Arrays
Authors: Scuderi Salvatore
Published: March 2024

The ASTRI Mini-Array is an Istituto Nazionale di Astrofisica (INAF) project to build and operate an array of nine Imaging Atmospheric Cherenkov Telescopes (IACTs) at the Teide Astronomical Observatory of the Instituto de Astrofisica de Canarias in Tenerife (Spain) based on a host agreement with INAF and, as such, it will be the largest IACT array until the Cherenkov Telescope Array Observatory starts operations. Implementing the ASTRI Mini-Array poses several challenges from technical, logistic, and management points of view. Starting from the description of the innovative technologies adopted to build the telescopes, we will discuss the solutions adopted to overcome these challenges, making the ASTRI Mini-Array a great instrument to perform deep observations of the galactic and extra-galactic sky at very high energies.
Insights from Avian Influenza: A Review of Its Multifaceted Nature and Future Pandemic Preparedness
Authors: He Jianning , Kam Yiu-Wing
Published: March 2024

Avian influenza viruses (AIVs) have posed a significant pandemic threat since their discovery. This review mainly focuses on the epidemiology, virology, pathogenesis, and treatments of avian influenza viruses. We delve into the global spread, past pandemics, clinical symptoms, severity, and immune response related to AIVs. The review also discusses various control measures, including antiviral drugs, vaccines, and potential future directions in influenza treatment and prevention. Lastly, by summarizing the insights from previous pandemic control, this review aims to direct effective strategies for managing future influenza pandemics.
Torque Teno Virus DNA Load in Blood as an Immune Status Biomarker in Adult Hematological Patients: The State of the Art and Future Prospects
Authors: Albert Eliseo , Giménez Estela , Hernani Rafael , Piñana José Luis , Solano Carlos , Navarro David
Published: March 2024

A solid body of scientific evidence supports the assumption that Torque teno virus (TTV) DNA load in the blood compartment may behave as a biomarker of immunosuppression in solid organ transplant recipients; in this clinical setting, high or increasing TTV DNA levels precede the occurrence of infectious complications, whereas the opposite anticipates the development of acute rejection. The potential clinical value of the TTV DNA load in blood to infer the risk of opportunistic viral infection or immune-related (i.e., graft vs. host disease) clinical events in the hematological patient, if any, remains to be determined. In fact, contradictory data have been published on this matter in the allo-SCT setting. Studies addressing this topic, which we review and discuss herein, are highly heterogeneous as regards design, patient characteristics, time points selected for TTV DNA load monitoring, and PCR assays used for TTV DNA quantification. Moreover, clinical outcomes are often poorly defined. Prospective, ideally multicenter, and sufficiently powered studies with well-defined clinical outcomes are warranted to elucidate whether TTV DNA load monitoring in blood may be of any clinical value in the management of hematological patients.
A Novel Tiled Amplicon Sequencing Assay Targeting the Tomato Brown Rugose Fruit Virus (ToBRFV) Genome Reveals Widespread Distribution in Municipal Wastewater Treatment Systems in the Province of Ontario, Canada
Authors: Nash Delaney , Ellmen Isaac , Knapp Jennifer J. , Menon Ria , Overton Alyssa K. , Cheng Jiujun , Lynch Michael D. J. , Nissimov Jozef I. , Charles Trevor C.
Published: March 2024

Tomato Brown Rugose Fruit Virus (ToBRFV) is a plant pathogen that infects important Solanaceae crop species and can dramatically reduce tomato crop yields. The ToBRFV has rapidly spread around the globe due to its ability to escape detection by antiviral host genes which confer resistance to other tobamoviruses in tomato plants. The development of robust and reproducible methods for detecting viruses in the environment aids in the tracking and reduction of pathogen transmission. We detected ToBRFV in municipal wastewater influent (WWI) samples, likely due to its presence in human waste, demonstrating a widespread distribution of ToBRFV in WWI throughout Ontario, Canada. To aid in global ToBRFV surveillance efforts, we developed a tiled amplicon approach to sequence and track the evolution of ToBRFV genomes in municipal WWI. Our assay recovers 95.7% of the 6393 bp ToBRFV RefSeq genome, omitting the terminal 5′ and 3′ ends. We demonstrate that our sequencing assay is a robust, sensitive, and highly specific method for recovering ToBRFV genomes. Our ToBRFV assay was developed using existing ARTIC Network resources, including primer design, sequencing library prep, and read analysis. Additionally, we adapted our lineage abundance estimation tool, Alcov, to estimate the abundance of ToBRFV clades in samples.
Serologic, Virologic and Pathologic Features of Cats with Naturally Occurring Feline Infectious Peritonitis Enrolled in Antiviral Clinical Trials
Authors: Murphy Brian G. , Castillo Diego , Neely N E , Kol Amir , Brostoff Terza , Grant Chris K. , Reagan Krystle L.
Published: March 2024

Feline infectious peritonitis (FIP) is a multisystemic, generally lethal immuno-inflammatory disease of domestic cats caused by an infection with a genetic variant of feline coronavirus, referred to as the FIP virus (FIPV). We leveraged data from four different antiviral clinical trials performed at the University of California, Davis. Collectively, a total of 60 client-owned domestic cats, each with a confirmed diagnosis of naturally occurring FIP, were treated with a variety of antiviral compounds. The tested therapies included the antiviral compounds GS-441524, remdesivir, molnupiravir and allogeneic feline mesenchymal stem/stroma cell transfusions. Four client-owned cats with FIP did not meet the inclusion criteria for the trials and were not treated with antiviral therapies; these cats were included in the data set as untreated FIP control cats. ELISA and Western blot assays were performed using feline serum/plasma or ascites effusions obtained from a subset of the FIP cats. Normalized tissue/effusion viral loads were determined in 34 cats by a quantitative RT-PCR of nucleic acids isolated from either effusions or abdominal lymph node tissue. Twenty-one cats were PCR “serotyped” (genotyped) and had the S1/S2 region of the coronaviral spike gene amplified, cloned and sequenced from effusions or abdominal lymph node tissue. In total, 3 untreated control cats and 14 (23.3%) of the 60 antiviral-treated cats died or were euthanized during (13) or after the completion of (1) antiviral treatment. Of these 17 cats, 13 had complete necropsies performed (10 cats treated with antivirals and 3 untreated control cats). We found that anticoronaviral serologic responses were persistent and robust throughout the treatment period, primarily the IgG isotype, and focused on the viral structural Nucleocapsid and Membrane proteins. Coronavirus serologic patterns were similar for the effusions and serum/plasma of cats with FIP and in cats entering remission or that died. Viral RNA was readily detectable in the majority of the cats in either abdominal lymph node tissue or ascites effusions, and all of the viral isolates were determined to be serotype I FIPV. Viral nucleic acids in cats treated with antiviral compounds became undetectable in ascites or abdominal lymph node tissue by 11 days post-treatment using a sensitive quantitative RT-PCR assay. The most common pathologic lesions identified in the necropsied cats were hepatitis, abdominal effusion (ascites), serositis, pancreatitis, lymphadenitis, icterus and perivasculitis. In cats treated with antiviral compounds, gross and histological lesions characteristic of FIP persisted for several weeks, while the viral antigen became progressively less detectable.
Brincidofovir Effectively Inhibits Proliferation of Pseudorabies Virus by Disrupting Viral Replication
Authors: Guo Huihui , Liu Qingyun , Yang Dan , Zhang Hao , Kuang Yan , Li Yafei , Chen Huanchun , Wang Xiangru
Published: March 2024

Pseudorabies is an acute and febrile infectious disease caused by pseudorabies virus (PRV), a member of the family Herpesviridae. Currently, PRV is predominantly endemoepidemic and has caused significant economic losses among domestic pigs. Other animals have been proven to be susceptible to PRV, with a mortality rate of 100%. In addition, 30 human cases of PRV infection have been reported in China since 2017, and all patients have shown severe neurological symptoms and eventually died or developed various neurological sequelae. In these cases, broad-spectrum anti-herpesvirus drugs and integrated treatments were mostly applied. However, the inhibitory effect of the commonly used anti-herpesvirus drugs (e.g., acyclovir, etc.) against PRV were evaluated and found to be limited in this study. It is therefore urgent and important to develop drugs that are clinically effective against PRV infection. Here, we constructed a high-throughput method for screening antiviral drugs based on fluorescence-tagged PRV strains and multi-modal microplate readers that detect fluorescence intensity to account for virus proliferation. A total of 2104 small molecule drugs approved by the U.S. Food and Drug Administration (FDA) were studied and validated by applying this screening model, and 104 drugs providing more than 75% inhibition of fluorescence intensity were selected. Furthermore, 10 drugs that could significantly inhibit PRV proliferation in vitro were strictly identified based on their cytopathic effects, virus titer, and viral gene expression, etc. Based on the determined 50% cytotoxic concentration (CC50) and 50% inhibitory concentration (IC50), the selectivity index (SI) was calculated to be 26.3–3937.2 for these 10 drugs, indicating excellent drugability. The antiviral effects of the 10 drugs were then assessed in a mouse model. It was found that 10 mg/kg brincidofovir administered continuously for 5 days provided 100% protection in mice challenged with lethal doses of the human-origin PRV strain hSD-1/2019. Brincidofovir significantly attenuated symptoms and pathological changes in infected mice. Additionally, time-of-addition experiments confirmed that brincidofovir inhibited the proliferation of PRV mainly by interfering with the viral replication stage. Therefore, this study confirms that brincidofovir can significantly inhibit PRV both in vitro and in vivo and is expected to be an effective drug candidate for the clinical treatment of PRV infections.
Detection of Acipenser European Iridovirus (AcIV-E) in Sturgeon Farms in Northern Italy between 2021–2023
Authors: Bondavalli Fabio , Schleicherová Dáša , Pastorino Paolo , Mugetti Davide , Pedron Claudio , Prearo Marino
Published: March 2024

Sturgeon farming is rapidly expanding in Europe, where Italy ranks first in farmed caviar production. A major threat to sturgeon health in captivity is infection with Acipenser European Iridovirus (AcIV-E), a viral disease definitively identified in 2016. Here we present data on the occurrence of AcIV-E in 482 sturgeons (age ≤ 12 months, species of the genus Acipenser and the species Huso huso) collected from sturgeon farms in northern Italy between January 2021 and December 2023. The health status of each specimen was determined by necroscopy and virological assay. Virological analysis was performed on gill samples and real-time PCR specific to the MCP gene of the iridovirus viral capsid. Molecular analysis revealed positivity to the virus in 204 samples (42.68% of the total), while anatomopathological examination of nearly all fish with positive real-time PCR disclosed swollen abdomen, hepatic steatosis, splenomegaly, and increased gill volume. Two challenges to timely diagnosis are the absence of pathognomonic symptoms and the inability to isolate the virus on cell monolayers. Continuous and widespread health monitoring is therefore crucial for disease management and to effectively control spread of the virus.
Unveiling a Shield of Hope: A Novel Multiepitope-Based Immunogen for Cross-Serotype Cellular Defense against Dengue Virus
Authors: Manocha Nilanshu , Laubreton Daphné , Robert Xavier , Marvel Jacqueline , Gueguen-Chaignon Virginie , Gouet Patrice , Kumar Prashant , Khanna Madhu
Published: March 2024

Dengue virus (DENV) infection continues to be a public health challenge, lacking a specific cure. Vaccination remains the primary strategy against dengue; however, existing live-attenuated vaccines display variable efficacy across four serotypes, influenced by host serostatus and age, and predominantly inducing humoral responses. To address this limitation, this study investigates a multiepitope-based immunogen designed to induce robust cellular immunity across all DENV serotypes. The chimeric immunogen integrates H-2d specific MHC-I binding T-cell epitopes derived from conserved domains within the DENV envelope protein. Immuno-informatics analyses supported its stability, non-allergenic nature, and strong MHC-I binding affinity as an antigen. To assess the immunogenicity of the multiepitope, it was expressed in murine bone-marrow-derived dendritic cells (BMDCs) that were used to prime mice. In this experimental model, simultaneous exposure to T-cell epitopes from all four DENV serotypes initiated distinct IFNγ-CD8 T-cell responses for different serotypes. These results supported the potential of the multiepitope construct as a vaccine candidate. While the optimization of the immunogen design remains a continuous pursuit, this proof-of-concept study provides a starting point for evaluating its protective efficacy against dengue infection in vivo. Moreover, our results support the development of a multiepitope vaccine that could trigger a pan-serotype anti-dengue CD8 response.
Self-Amplifying RNA: A Second Revolution of mRNA Vaccines against COVID-19
Authors: Silva-Pilipich Noelia , Beloki Uxue , Salaberry Laura , Smerdou Cristian
Published: March 2024

SARS-CoV-2 virus, the causative agent of COVID-19, has produced the largest pandemic in the 21st century, becoming a very serious health problem worldwide. To prevent COVID-19 disease and infection, a large number of vaccines have been developed and approved in record time, including new vaccines based on mRNA encapsulated in lipid nanoparticles. While mRNA-based vaccines have proven to be safe and effective, they are more expensive to produce compared to conventional vaccines. A special type of mRNA vaccine is based on self-amplifying RNA (saRNA) derived from the genome of RNA viruses, mainly alphaviruses. These saRNAs encode a viral replicase in addition to the antigen, usually the SARS-CoV-2 spike protein. The replicase can amplify the saRNA in transfected cells, potentially reducing the amount of RNA needed for vaccination and promoting interferon I responses that can enhance adaptive immunity. Preclinical studies with saRNA-based COVID-19 vaccines in diverse animal models have demonstrated the induction of robust protective immune responses, similar to conventional mRNA but at lower doses. Initial clinical trials have confirmed the safety and immunogenicity of saRNA-based vaccines in individuals that had previously received authorized COVID-19 vaccines. These findings have led to the recent approval of two of these vaccines by the national drug agencies of India and Japan, underscoring the promising potential of this technology.
Evaluation of Water Quality of Groundwater of Sanghar District, Sindh, Pakistan: Chemical and Multivariate Analysis
Authors: Landar Abdul Qayoom , Jahangir Taj Muhammad , Khuhawar Muhammad Yar , Lanjwani Muhammad Farooque , Khuhawar Faheem Yar
Published: March 2024

Sanghar District is located in the central part of Sindh Province and shares a boarder with India to the east. This work examines the water quality of the groundwater of three subdistricts, Sanghar, Khipro, and Jan Nawaz Ali, mostly used for human consumption, cattle farming, and irrigation. A total of 74 representative samples were collected and analyzed for 26 different parameters, including anions, cations, trace, and toxic elements. The total dissolved salts (TDSs) contained in 41 samples (55.4%), the major cations, K, Na, Mg, and Ca, in 44.6–93.2% of samples, and the major anions, Cl, HCO3, and SO4, in 68.6–81.0% of samples were within the permissible guidelines of the World Health Organization (WHO). The samples containing elements Cr (24.0%), Pb (29.7%), Ni (39.2%), Cd (40.5%), As (10.8%), and F (39.18%) were above the permissible limits of the WHO. The groundwater samples were examined for water quality index (WQI), contamination index (Cd), chronic daily intake indices (CDIs), hazard quotient indices (HQ), principal component analysis (PCA), piper diagrams, Gibbs diagrams, and cluster analysis to ascertain nature of the groundwater present in the study area. The samples were also examined for suitability for irrigation by sodium percentage (Na%), sodium adsorption ratio (SAR), Kelly’s index (KI), permeability index (PI), and Wilcox diagrams. Samples in the range of 0 to 58.33% were inappropriate for irrigation.
Treatment of Cadmium-Contaminated Water Systems Using Modified Phosphate Rock Powder: Contaminant Uptake, Adsorption Ability, and Mechanisms
Authors: Gao Shuo , Kang Xirui , Li Yaping , Yu Jinpeng , Wang Hui , Pan Hong , Yang Quangang , Yang Zhongchen , Sun Yajie , Zhuge Yuping , Lou Yanhong
Published: March 2024

Cadmium (Cd) water pollution threatens environmental systems and human health. Adsorption is the preferred method for purifying water bodies polluted by Cd, and the development of effective adsorption materials is critical. The performance of original phosphate rock powder (PRP) as an adsorption medium for purifying water bodies polluted by Cd was compared with that of phosphate rock powder modified with fulvic acid, chitosan, MnO2, and sulfhydryl, respectively, and their appearance and adsorption properties were investigated. The surface structures of all modified powders were rougher than the original, and their functional groups were richer. The greatest Cd2+ adsorption capacity, 1.88 mg g−1, was achieved with chitosan-modified PRP (CMPRP). This was 106.59% greater than that of PRP. The capacities of fulvic acid and MnO2 were 15.38% and 4.40% greater than that of the original, respectively. When the fulvic acid-modified PRP, CMPRP, and manganese dioxide PRP reached adsorption equilibrium, the removal rates of Cd2+ were 51.86%, 93.26%, and 46.70%, respectively. Moreover, the removal rate of Cd2+ by CMPRP was 104.43% higher than that of PRP. The main Cd2+ adsorption mechanisms for the MPRPs were electrostatic interactions, ion exchange, co-precipitation, and complexation. Moreover, the processing of the phosphate rock powder was straightforward, harmless to the environment, and could be effectively used for the removal of Cd. These results show that CMPRP is promising as a new adsorption material to treat Cd-contaminated water.
Potential Influence of Suspended Sediments on the Population Dynamics and Behavior of Filter-Feeding Brachycentrus occidentalis (Trichoptera: Brachycentridae) Larvae in a Southeastern Minnesota, USA, Trout Stream
Authors: Mundahl Neal D. , Mundahl Erik D.
Published: March 2024

Suspended and deposited sediments in streams can interfere with filter-feeding caddisfly larvae by reducing feeding sites and feeding efficiency, potentially lowering the densities, growth rates, and secondary production of an important trout prey. We conducted field studies at multiple stream sites with differing suspended-sediment loads, and a laboratory study was conducted under controlled conditions; together, these were designed to examine the role of suspended sediments in the population dynamics and behavior of Brachycentrus occidentalis (Trichoptera: Brachycentridae) larvae in a Minnesota, USA, trout stream. Stream sites that had elevated turbidities and elevated levels of suspended sediments also had significantly more fine bottom substrates and higher substrate embeddedness. In addition, Brachycentrus densities were reduced, growth rates were slower, secondary production was reduced, and the overall benthic macroinvertebrate taxa richness was lowest at the site with the highest suspended-sediment loading. Colder water temperatures at one site also influenced Brachycentrus production. In 24 h laboratory studies conducted in recirculating aquaria, the feeding activities of Brachycentrus larvae were reduced and their positioning altered under high turbidities (500 nephelometric turbidity units, NTU) relative to low turbidities (50 NTU or lower). High suspended-sediment loads have adversely affected filter-feeding caddisfly larvae by embedding and burying preferred coarse feeding substrates, altering their feeding positions and movements during the highest flows, and potentially impacting densities, growth rates, and secondary production.
Stocks and Sources of Soil Carbon and Nitrogen in Non-Native Kandelia obovata Afforestation and Spartina alterniflora Invasion: A Case Study on Northern Margin Mangroves in the Subtropical Coastal Wetlands of China
Authors: Ye Qianwen , Hou Cuicui , Wang Qiang , Gao Changjun , Stefanik Kay , Li Feng , Jiang Bingbing
Published: March 2024

For decades in China, carbon neutrality policies have spurred the establishment of northern margin mangroves as artificial blue carbon ecosystems. However, there has been limited research on the impact of plantation and invasion on the stocks and sources of soil carbon and nitrogen in rehabilitated coastal wetlands. Non-native Kandelia obovata afforestation began on Ximen Island, Zhejiang, China, where Spartina alterniflora invasion had also occurred decades ago. Soil cores were collected from both mangrove and salt marsh habitats with depths from 0 to 50 cm and were analyzed for total carbon (TC), soil organic carbon (SOC), total nitrogen (TN), and the isotope of carbon and nitrogen in sediments. The results indicated that there were no significant differences in the TC, SOC, and C/N ratio between the K. obovata and the S. alterniflora, but there were significant differences in TN, isotope δ13C, and δ15N. The SOC content of both ecosystems in the 0–20 cm layer was significantly higher than that in the 30–50 cm layer. Our study has shown that the main sources of carbon and nitrogen for mangroves and salt marshes are different, especially under the impact of external factors, such as tidal waves and aquaculture. These findings provide insight into the ecological functioning of subtropical coastal wetlands and an understanding of the biogeochemical cycles of northern margin mangrove ecosystems.
Measurements and Simulations of the Flow Distribution in a Down-Scaled Multiple Outlet Spillway with Complex Channel
Authors: Hedberg P. A. Mikael , Hellström J. Gunnar I. , Andersson Anders G. , Andreasson Patrik , Andersson Robin L.
Published: March 2024

Measurements of mass flow through a three-outlet spillway modeled after a scaled-down spillway were conducted. The inlet and channel leading up to the outlets were placed to lead the water toward the outlet at an angle. With this, measurements of the water level at three locations were recorded by magnetostrictive sensors. The volumetric flow rates for each individual outlet were recorded separately to study the differences between them. Additionally, Acoustic Doppler Velocimetry was used to measure water velocities close to the outlets. The conditions changed were the inlet volume flow rate and the flow distribution was measured at 90, 100, 110, and 200 L per second. Differences between the outlets were mostly within the error margin of the instruments used in the experiments with larger differences shown for the 200 L test. The results produced together with a CAD model of the setup can be used for verification of CFD methods. A simulation with the k-epsilon turbulence model is included and compared to earlier experiments and the new experimental results. Larger differences are seen in the new experiments. Differing inlet conditions are assumed as the principal cause for the differences seen.
Reducing Water Conveyance Footprint through an Advanced Optimization Framework
Authors: Jafari-Asl Jafar , Hashemi Monfared Seyed Arman , Abolfathi Soroush
Published: March 2024

This study investigates the optimal and safe operation of pumping stations in water distribution systems (WDSs) with the aim of reducing the environmental footprint of water conveyance processes. We introduced the nonlinear chaotic honey badger algorithm (NCHBA), a novel and robust optimization method. The proposed method utilizes chaotic maps to enhance exploration and convergence speed, incorporating a nonlinear control parameter to effectively balance local and global search dynamics. Single-objective optimization results on a WDS show that NCHBA outperforms other algorithms in solution accuracy and convergence speed. The application of the proposed approach on a water network with two variable-speed pumps demonstrated a significant 27% reduction in energy consumption. Expanding our focus to the multi-objective optimization of pump scheduling programs in large-scale water distribution systems (WDSs), we employ the non-dominated sorting nonlinear chaotic honey badger algorithm (MONCHBA). The findings reveal that the use of variable-speed pumps not only enhances energy efficiency but also bolsters WDS reliability compared to the use of single-speed pumps. The results showcase the potential and robustness of the proposed multi-objective NCHBA in achieving an optimal Pareto front that effectively balances energy consumption, pressure levels, and water quality risk, facilitating carbon footprint reduction and sustainable management of WDSs.
Enrichment, Bioaccumulation and Health Risks of Trace Metals in Soils and Leafy Vegetables Grown on the Banks of the Ugandan Lifeline River, River Rwizi
Authors: Rutehenda Deus R. , Adaku Christopher , Omara Timothy , Angiro Christopher , Ntambi Emmanuel
Published: March 2024

Urban vegetable farming in wetlands and riverbanks are common features of Ugandan cities. However, urbanization has led to various anthropogenic activities that can lead to the pollution of water resources, enrichment of pollutants in soils and, consequently, pollutant bioaccumulation in edible tissues of plants cultivated on such soils. In this study, we report on the levels of six trace metals (TMTs) in 75 samples of leafy vegetables (Brassica oleracea L., Spinacia oleracea L., Amaranthus hybridus L., Cucurbita pepo L. and Solanum nigrum L.) and soils (n = 75) grown on the banks of River Rwizi, the second longest river in Uganda only after the Nile River. The concentrations of TMTs (Mn, Zn, Cd, Pb, Cr and Cu) in edible vegetable tissues and soils were quantified using flame atomic absorption spectrometry. The mean concentrations (in mg kg−1) of the TMTs in the soil samples were 205–373.84 (Mn), 12.72–65.04 (Zn), 0.26–0.42 (Cd), 3.36–16.80 (Pb), 5.96–25.06 (Cr) and 2.83–35.27 (Cu). In vegetable samples, the concentrations ranged from 43.25 to 110.00 (Mn), 1.08 to 1.83 (Cd), 41.06 to 71.20 (Zn), 4.31 to 6.16 (Pb), 0.65 to 0.81 (Cr) and 5.70 to 14.35 (Cu). With the exception of Mn and Cr, the rest of the TMTs were bioaccumulated in the edible vegetable tissues (bioconcentration factors = 1.03 to 10.71). Considering chronic daily intake through ingestion, dermal contact and inhalation of the TMTs in soils from the banks of River Rwizi, there are no potential non-cancer and carcinogenic health effects that could be experienced in both adults and children. Consumption of leafy vegetables could pose both non-cancer health risks (from ingestion of Zn, Pb, Cr, Mn and Cd) and cancer health risks (due to intake of Cd) in both children and adults. There is therefore a need to enforce regulations to mitigate the pollution of River Rwizi for a more sustainable economic development.
Social Media Addiction, Personality Factors and Fear of Negative Evaluation in a Sample of Young Adults
Authors: Piko Bettina F. , Krajczár Seron Kíra , Kiss Hedvig
Published: March 2024

Despite growing attention paid to exploring the benefits as well as negative consequences of social media use, we know less about the background variables involved in social media addiction. Therefore, the aim of this study was to investigate several potential contributors to addiction to social media, namely, self-esteem, fear of negative evaluation, sensation seeking and five personality variables. The participants of the online survey were Hungarian university students (N = 250, aged between 18 and 35 years; 59.2% female). Females scored higher on the social media addiction scale [t(248) = −2.42, p < 0.05]. The findings showed that (a) fear of negative evaluation positively predicted social media addiction (β = 0.28, p < 0.001) and (b) self-esteem (β = −0.23, p < 0.01) and conscientiousness (β = −0.14, p < 0.05) negatively predicted social media addiction in this sample of young adults. Additionally, social media addiction was negatively correlated with emotional stability [r (250) = −0.38, p < 0.001] and positively with extraversion; however, these variables were not significant predictors in the multivariate analysis. These findings suggest that young people should learn how to carefully use the Internet and social media settings, e.g., courses on addiction to digital devices should be accessible to all university students.
К флоре мхов полуострова Кони (Ольский участок Государственного природного заповедника "Магаданский")
Authors:   Institute of Biological Problems of the North, FEB RAS, Magadan, Vilk E. F. ,   Magadan State Nature Reserve, Magadan
Published: March 2024

Based on the results of processing the materials collected during a few field seasons and considering the available publications, data on the mosses in the Ola lot of the Magadan Nature Reserve are presented. The list includes 138 species belonging to 67 genera and 35 families. Some peculiarities of the studied flora are discussed on the base of the data received.
Научный вклад А. Г. Козлова в изучение истории Северо-Востока России
Authors:   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan, Lebedintsev A. I.
Published: March 2024

The article presents the main results of the scientific activities of A. G. Kozlov (1951-2006), Senior Researcher at the Laboratory of History and Archeology of the North-East Interdisciplinary Scientific Research Institute of the FEB RAS, local historian, and populiser of science. In 1997-2006, he was involved with various problems of Magadan оblast history, peculiarities in the industrial development of Russia's North-East, the Dalstroy economic activities, correctional labour policy in the area in the 1930s-1950s, as well as the foundation and development of the city of Magadan. A. G. Kozlov made a significant contribution to studying the history of Magadan oblast.
Self-care Ability and Demographic Characteristics among Older Adults in the Urban and Rural Areas of Miandoab, Iran
Authors: Safaiyan Abdolrasoul , Khami Behnam , Abbasian Mehdi , Nikanfar Reza , Matlabi Hossein
Published: March 2024

Objectives: Self-care helps older adults manage their health and stay independent by delaying disability. This study aimed to study the self-care ability and demographic characteristics of older adults in urban and rural areas of Miandoab. Design: This cross-sectional study was conducted in 2017, encompassing a total of 620 older adults aged 60 years and above. Participants: Eligible older adults were selected using stratified random sampling method from both urban and rural healthcare centers located in Miandoab, Iran. The data collection instruments comprised a demographic questionnaire and self-care ability. Data analysis was conducted using SPSS version 18 software employing t-tests and one-way analysis of variance. Results: The mean ± standard deviation of self-care was higher in the physical dimension of the older adults living in rural areas (80.64±0.81), males (90.69±1.00), married elderly (90.87±0.75), illiterate elderly (94.67±1.08), employed individuals (91.78±0.98), those with less than 65 years old (95.18±0.69), and old adults with an income level of more than 2 million (93.36±1.56). Moreover, a statistically significant difference was observed (P<0.05). Conclusions: Demographic factors such as the place of residence, marriage, economic sufficiency, and lifestyle influenced the level of self-care. The findings suggest providing measures to improve the quality of life of older adults. The members of the rural family physicians’ health team and healthcare providers in urban areas should play a more substantial role in training and improving self-care
Aging Population in Vietnam: Challenges, Implications, and Policy Recommendations
Authors: Maheshwari Anika , Maheshwari Greeni
Published: March 2024

Objectives: This paper aimed to critically examine challenges of Vietnam in addressing its aging population, highlighting its status as the third fastest aging nation in ASEAN, after Singapore and Thailand. The primary goals are to grasp the impending demographic shift and offer recommendations for policymakers. Design: This study is a comprehensive review providing insights into the aging situation in Vietnam. It focused on short and long-term strategies to tackle challenges posed by the rapidly growing older adult population. It contextualized the aging issue in its socio-economic landscape. The review spanned 2020 to 2050, outlining the expected transformation in the population aged 65 years or above. Setting(s): The study has focused on Vietnam’s aging population by consolidating the secondary data sources. Participants: The study is a secondary data and hence various secondary sources have been used to analyze the data of this study. Interventions: There are no interventions used in this study. Outcome measures: Anticipated changes in the percentage of the population aged 65 years or above serve as outcome measures. This commentary projects an increase from nearly 7% in 2020 to 14% by 2035, tripling to 21% by 2050, indicating the magnitude of the aging challenge in Vietnam. Results: The present review proposes recommendations to address the aging issue, including boosting the skilled workforce, investing in technology and research and development (R&D), enhancing human capital, promoting international migration, creating additional funding opportunities, and introducing social protection measures. The results section encapsulates these suggested strategies as potential solutions to identified challenges. Conclusions: Vietnam faces a significant aging challenge with a rapid increase in the older adult population. This commentary advocates for a proactive approach by policymakers. The recommended strategies, both short and long-term, aim to mitigate economic and social challenges associated with an aging population. The conclusion stresses the importance of timely and effective policy measures to ensure sustainable development amid demographic changes in Vietnam.
Environmental Fate Modelling of Lead Contamination in Water and Sediments of Hawizeh Marshes
Authors: Bayatzadeh Mohsen , Karimi Organi Fatemeh , Koshafar Azita , Sabzalipour Sima , Mohammadi Rouzbahani Maryam
Published: March 2024

Background: This study aimed to determine the maximum concentration of lead in the water and sediments of Hawizeh Swamp during 2020-2021. Methods: The ECOFATE model was employed to calculate ecological risk parameters (RQ) along with total dissolved solids (TDS), total suspended solids (TSS), and total organic carbon (TOC) at four stations during summer and winter. Using the framework of environmental fate model of ECOFATE, comprehensive data on hydrological sections, input chemical quantities, chemical characteristics, and ecosystem attributes were measured. Results: The findings indicated that lead concentrations were at the highest level in both sediment and water samples of the wetland across three-dimensional space during summer and winter. TSS, TOC and TDS values were estimated, of which the TDS was used to measure ecological risk due to its higher values. Conclusion: The RQ values of lead indicated high and medium risk within the sedimentary and aquatic environments of the wetland ecosystem, respectively. Statistical calculations further revealed that this wetland was at risk of environmental pollution, posing potential hazards to humans through the food chain. The increase in the biological pollution of this wetland is due to the increase in the population and urban sewage. Therefore, it is imperative to raise public awareness regarding the significance of the wetland and advocate for its regular monitoring.
Investigating the Growth Rate of Tetraselmis Algae and its Effect on Nitrogen Removal From Aquaculture Wastewater
Authors: Ghadamzadeh Mahsa , Jalilzadeh Yengejeh Reza , Javadzadeh Narges , Koushafar Azita , Attarroshan Sina
Published: March 2024

Background: This research investigated the ability of Tetraselmis microalgae to remove nitrates from aquaculture centers’ wastewater. Specifically, this study aimed to investigate the amount of nitrogen reduction by Tetraselmis microalgae under laboratory conditions. Therefore, algal density, chlorophyll a, specific growth rate, nitrate, and ammonia levels were investigated. Methods: Tetraselmis microalgae was planted under laboratory conditions with constant density of 2000 mL including 1900 mL of distilled water and 100 mL of stock to investigate the refining effects for 15 days. Along to the test steps, the concentration of the mentioned factors was determined using standard methods and ultraviolet spectrophotometer. Results: The results showed that algal density, chlorophyll concentration, and specific growth rate performed better than others in the pilot plants containing wastewater. Also, use of the studied algae caused a 50% reduction in ammonia and 80% in nitrate from aquaculture center wastewater. The data modeling showed that the above-mentioned microalgae were effective in reduction of nitrogen from aquaculture center wastewater as much as 75%. Conclusion: The results showed that the species can reduce organic substances in the wastewater of aquaculture center and their discharge into the environment.
Environmental Risk Assessment of a Hydrocracker Unit in Abadan Oil Refinery Using the EFMEA Analysis
Authors: Mahdavi Ali , Varshosaz Katayoon
Published: March 2024

Background: The aim of risk assessment is to use a rational method to analyze risks and to identify the possible hazards and outcomes for people, equipment, materials, and the environment. Methods: The criteria and indices for assessing the environmental, health, and safety risks of the hydrocracker unit were determined by a Delphi questionnaire in this study. Then, an Environmental Failure Mode and Effects Analysis was applied to evaluate, score, and rank the risks based on their probability of occurrence, severity, probability of detection, extent of pollution, and potential of recycling. Results: According to the results of the Delphi process, 19 out of the 22 items were identified as the main criteria in the environmental, health, and safety risk evaluation of the hydrocracker unit at the Abadan Oil Refinery. However, the results indicated that 67% of the risks associated with the life cycle operation were low while 33% of them were high in terms of intensity. In contrast, 75% of the risks associated with control room operators were low and 25% were high in terms of intensity. On the other hand, 64, 7, and 29% of the risks associated with the activities of site employees were low, moderate, and high in terms of intensity, respectively, while the corresponding figures were 14, 29, and 57% in the case of risks associated with repairs. Conclusion: Based on the results of techniques of environmental failure modes and effects analysis (EFMEA) and Delphi, appropriate methods can be used to identify and reduce risks in similar industries.
Variations of PM2.5 and Health Risk Assessment in the City of Mashhad During 2010-2018
Authors: Rafiee Omid , Miri Mohammad , Taghavi Mahmud
Published: March 2024

Background: Air pollution stands as a significant environmental threat impacting human health across the globe, encompassing both developed and developing nations. This study aimed to survey the temporal variations of PM2.5 and gauge its potential health effects in the city of Mashhad over the period of 2010-2018. Methods: This cross-sectional study was carried out among the residents of Mashhad city. PM2.5 concentration data spanning the years 2008-2019 were collected and subjected to analysis using Excel and AirQ software. Results: The results indicate that the highest concentration of PM2.5 was associated with the year 2010, while the lowest concentration was observed in 2015. The analytical findings demonstrated that for each 10 µg/m3 increase in PM2.5 concentrations, the relative risk for total mortality increased by 10.47%. Furthermore, based on the Air Quality Index (AQI) results, 2010 exhibited the most adverse condition in terms of PM2.5 concentrations in Mashhad city. Conclusion: In general, long-term exposure to ambient PM2.5 significantly contributed to mortality in the megacity of Mashhad. As air pollution is a modifiable risk factor, it is advisable to implement sustainable control policies to protect public health.
Low-dose, high-pitch, spiral (FLASH) mode versus conventional sequential method for coronary artery calcium scoring: A derivation-validation study
Authors: Pandey Niraj Nirmal , Chakraborty Sayannika , Verma Mansi , Jagia Priya
Published: March 2024

Introduction: The present study sought to compare the diagnostic accuracy and radiation dose of ECG-gated, ultra-fast, low-dose, high-pitch, spiral (FLASH) mode versus conventional, ECG-gated, sequential coronary artery calcium (CAC) scoring in patients with suspected coronary artery disease (CAD). Methods: The study included 120 patients who underwent both conventional scanning and FLASH mode scanning and were subdivided into derivation and validation cohorts. In the conventional sequential (step-and-shoot) protocol, prospective ECG-gated, non-contrast acquisition was performed at 70% of R-R interval. The spiral (FLASH) mode utilized a high-pitch and high-speed gantry rotation scanning mode where acquisition of the entire heart was done within a single cardiac cycle with prospective ECG-gating at 70% of R-R interval. Results: Correlation between CAC scores derived from conventional (cCAC) and FLASH mode (fCAC) in derivation cohort was excellent (r=0.99; P<0.001). A linear regression model was used to develop a formula for deriving the estimated CAC score (eCAC) from fCAC (eCAC=0.978 x fCAC). In validation cohort, eCAC showed excellent agreement with cCAC (ICC=0.9983; 95%CI: 0.9972 - 0.9990). Excellent agreement for risk classification (weighted kappa=0.93898; 95%CI: 0.86833 - 1.0000) was observed with 95% (57/60) scores falling within the same risk category. Effective dose was significantly lower in FLASH mode (conventional, 0.58±0.21 mSv vs. FLASH, 0.34±0.12 mSv; P<0.0001). Conclusion: CAC scoring using FLASH mode is feasible with high accuracy and shows excellent agreement with conventional CAC scores at significantly reduced radiation doses.