bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study)
Authors: Valls Rosa M. , Pedret Anna , Calderón-Pérez Lorena , Llauradó Elisabet , Pla-Pagà Laura , Companys Judit , Moragas Ana , Martín-Luján Francisco , Ortega Yolanda , Giralt Montse , Romeu Marta , Rubió Laura , Mayneris-Perxachs Jordi , Canela Núria , Puiggrós Francesc , Caimari Antoni , Del Bas Josep M. , Arola Lluís , Solà Rosa
Published: July 2020

Purpose

To assess the sustained and acute effects, as well as the influence of sustained consumption on the acute effects, of orange juice (OJ) with a natural hesperidin content and hesperidin-enriched OJ (EOJ) on blood (BP) and pulse (PP) pressures in pre- and stage-1 hypertensive individuals.

Methods

In a randomized, parallel, double-blind, placebo-controlled trial, participants (n = 159) received 500 mL/day of control drink, OJ, or EOJ for 12 weeks. Two dose–response studies were performed at baseline and after 12 weeks.

Results

A single EOJ dose (500 mL) reduced systolic BP (SBP) and PP, with greater changes after sustained treatment where a decrease in diastolic BP (DBP) also occurred (P < 0.05). SBP and PP decreased in a dose-dependent manner relative to the hesperidin content of the beverages throughout the 12 weeks (P < 0.05). OJ and EOJ decreased homocysteine levels at 12 weeks versus the control drink (P < 0.05). After 12 weeks of EOJ consumption, four genes related to hypertension (PTX3, NLRP3, NPSR1 and NAMPT) were differentially expressed in peripheral blood mononuclear cells (P < 0.05).

Conclusion

Hesperidin in OJ reduces SBP and PP after sustained consumption, and after a single dose, the chronic consumption of EOJ enhances its postprandial effect. Decreases in systemic and transcriptomic biomarkers were concomitant with BP and PP changes. EOJ could be a useful co-adjuvant tool for BP and PP management in pre- and stage-1 hypertensive individuals.
Peri- and postmenopause—diagnosis and interventions interdisciplinary S3 guideline of the association of the scientific medical societies in Germany (AWMF 015/062): short version
Authors: Ortmann Olaf , Beckermann Maria J. , Inwald Elisabeth C. , Strowitzki Thomas , Windler Eberhard , Tempfer Clemens ,   For the guideline group
Published: July 2020

This short version of the interdisciplinary S3 guideline “Peri- and Postmenopause—Diagnosis and Interventions” is intended as a decision-making instrument for physicians who counsel peri- and postmenopausal women. It is designed to assist daily practice. The present short version summarizes the full version of the guideline which contains detailed information on guideline methodology, particularly regarding the critical appraisal of the evidence and the assignment of evidence levels. The statements and recommendations of the full version of the guideline are quoted completely in the present short version including levels of evidence (LoE) and grades of recommendation. The classification system developed by the Centre for Evidence-based Medicine in Oxford was used in this guideline.
Independent predictors of secondary invasive pancreatic remnant tumors after initial resection of an intraductal papillary mucinous neoplasm: a nationwide large-scale survey in Japan
Authors: Takigawa Yutaka , Kitago Minoru , Matsui Junichi
Published: July 2020

Purpose

There is no standardized surveillance protocol after intraductal papillary mucinous neoplasm (IPMN) resection. We report the findings of a large-scale survey in Japan, investigating the independent predictors of secondary invasive tumors by analyzing the epidemiology of secondary tumors of the remnant pancreas after initial IPMN resection.

Methods

An institutional questionnaire about the remnant pancreas after pancreas resection was distributed at the 41st Annual Meeting of the Japanese Society of Pancreatic Surgery in Tokyo. We retrospectively analyzed the patient data including pathological diagnosis, postoperative outcomes, and evaluation methods.

Results

Redo pancreatectomy was performed for secondary disease in 213 (1.4%) of a total 15,777 patients. Eighty-eight of these 213 patients had undergone initial resection of IPMN. The types of secondary tumors after IPMN resection significantly depended on those of the primary tumors. Through short-interval and long-term follow-up, most of the secondary tumors were detected within 1–4 years. Logistic regression analysis revealed that the initial pathological diagnosis of invasive IPMN was an independent predictor of secondary invasive tumors in the remnant pancreas.

Conclusion

Primary invasive IPMN proved to be a significant predictor of secondary invasive IPMN. Both short-interval and long-term follow-up may help to determine the prognosis of patients after IPMN resection.
Role of endoscopic ultrasound for gallbladder disease
Authors: Tanaka Kazunari , Katanuma Akio , Hayashi Tsuyoshi , Kin Toshifumi , Takahashi Kuniyuki
Published: July 2020

Endoscopic ultrasonography (EUS) has excellent spatial resolution and allows more detailed examination than abdominal ultrasonography (US) in terms of qualitative diagnosis of tumors and evaluation of tumor invasion depth. To understand the role of EUS in gallbladder disease, we need to understand the normal gallbladder wall structure and how to visualize it on EUS. In addition, gallbladder lesions can be classified into two broad categories: protuberant and wall-thickening lesions. Here, the features on EUS were outlined. We also outlined the current status of EUS-FNA for gallbladder lesions as there have been scattered reports of EUS-FNA in recent years.
Electrocorticography Evidence of Tactile Responses in Visual Cortices
Authors: Gaglianese Anna , Branco Mariana P. , Groen Iris I. A. , Benson Noah C. , Vansteensel Mariska J. , Murray Micah M. , Petridou Natalia , Ramsey Nick F.
Published: July 2020

There is ongoing debate regarding the extent to which human cortices are specialized for processing a given sensory input versus a given type of information, independently of the sensory source. Many neuroimaging and electrophysiological studies have reported that primary and extrastriate visual cortices respond to tactile and auditory stimulation, in addition to visual inputs, suggesting these cortices are intrinsically multisensory. In particular for tactile responses, few studies have proven neuronal processes in visual cortex in humans. Here, we assessed tactile responses in both low-level and extrastriate visual cortices using electrocorticography recordings in a human participant. Specifically, we observed significant spectral power increases in the high frequency band (30–100 Hz) in response to tactile stimuli, reportedly associated with spiking neuronal activity, in both low-level visual cortex (i.e. V2) and in the anterior part of the lateral occipital–temporal cortex. These sites were both involved in processing tactile information and responsive to visual stimulation. More generally, the present results add to a mounting literature in support of task-sensitive and sensory-independent mechanisms underlying functions like spatial, motion, and self-processing in the brain and extending from higher-level as well as to low-level cortices.
Triclosan changes community composition and selects for specific bacterial taxa in marine periphyton biofilms in low nanomolar concentrations
Authors: Martin Eriksson Karl , Kemal Sanli , Henrik Nilsson Rickard , Alexander Eiler , Natalia Corcoll , Henrik Johansson Carl , Thomas Backhaus , Hans Blanck , Erik Kristiansson
Published: July 2020

The antibacterial agent Triclosan (TCS) is a ubiquitous environmental contaminant due to its widespread use. Sensitivity to TCS varies substantially among eu- and pro-karyotic species and its risk for the marine environment remains to be better elucidated. In particular, the effects that TCS causes on marine microbial communities are largely unknown. In this study we therefore used 16S amplicon rDNA sequencing to investigate TCS effects on the bacterial composition in marine periphyton communities that developed under long-term exposure to different TCS concentrations. Exposure to TCS resulted in clear changes in bacterial composition already at concentrations of 1 to 3.16 nM. We conclude that TCS affects the structure of the bacterial part of periphyton communities at concentrations that actually occur in the marine environment. Sensitive taxa, whose abundance decreased significantly with increasing TCS concentrations, include the Rhodobiaceae and Rhodobacteraceae families of Alphaproteobacteria, and unidentified members of the Candidate division Parcubacteria. Tolerant taxa, whose abundance increased significantly with higher TCS concentrations, include the families Erythrobacteraceae (Alphaproteobacteria), Flavobacteriaceae (Bacteroidetes), Bdellovibrionaceae (Deltaproteobacteria), several families of Gammaproteobacteria, and members of the Candidate phylum Gracilibacteria. Our results demonstrate the variability of TCS sensitivity among bacteria, and that TCS can change marine bacterial composition at concentrations that have been detected in the marine environment.
COVID-19 Pandemic: An Insult Over Injury for Lebanon
Authors: Bizri Abdul Rahman , Khachfe Hussein H. , Fares Mohamad Y. , Musharrafieh Umayya
Published: July 2020

The outbreak of the novel coronavirus disease in 2019 (COVID-19) caused a plethora of challenges worldwide and tested healthcare systems across the six continents. Lebanon had recently faced harsh political and economic crises. We aim to describe the effect of COVID-19 on an already crisis-stricken country. A descriptive analysis of the burden of COVID-19 pandemic on Lebanon was performed. Relevant data on COVID-19 was retrieved from the Lebanese Ministry of Public Health from February 21 till June 13th, 2020. Results obtained were analyzed and a literature review was performed. 1422 confirmed COVID-19 cases were identified and reported in Lebanon by June 13th, 2020, comprising an incidence rate of 208/million persons. There has been a total of 31 deaths thus far, with a reported death rate of 5/million persons. The age group with the highest number of cases was 20–29 years. Beirut was the district with the highest number of cases (18%). The COVID-19 crisis has impacted the country on a multifactorial level. COVID-19 could not have come at a worse time for Lebanon. The country is on brink of bankruptcy, the healthcare system is struggling for survival and the government is striving to regain the trust of the population.
New results for an open time-dependent scheduling problem
Authors: Gawiejnowicz Stanisław , Kurc Wiesław
Published: July 2020

We present several new results for a single machine time-dependent scheduling problem of minimizing the total completion time of a set of linearly deteriorating jobs with unit basic processing times. First, we show new properties of cyclic transformations of V-shaped sequences for this problem. Next, applying the results, we prove a new necessary condition of schedule optimality for the considered problem, which decreases the previous bound on the cardinality of the set containing all possible optimal schedules by a multiplicative factor which is at most proportional to the reciprocal of the square root of the number of jobs. Finally, we compare the strength of the new and the previous necessary conditions by estimation of the numbers of schedules satisfying the respective conditions.
Thermal decomposition and spectral characterization of di[carbonatotetraamminecobalt(III)] sulfate trihydrate and the nature of its thermal decomposition products
Authors: Franguelli Fernanda Paiva , Barta-Holló Berta , Petruševski Vladimir M. , Sajó Istvan E. , Klébert Szilvia , Farkas Attila , Bódis Eszter , Szilágyi Imre Miklós , Pawar Rajendra P. , Kótai László
Published: July 2020

Detailed vibrational (IR, Raman, far-IR) and thermal (TGA, TG–MS, DSC) analysis has been performed on di[κ1O,κ2O-carbonatotetraamminecobalt(III)] sulfate trihydrate, ([Co(NH3)4CO3]2SO4·3H2O (1). Its isothermic heating at 100 °C leads to formation of [Co(NH3)4CO3]2SO4(compound2). UV and IR studies showed that the distorted octahedral arrangement around cis-O2CoN4core in compound1does not change during dehydration, which explains the reversible water loss and ability of compound2to rehydrate into compound1. Compound2decomposes at ~ 240 °C in inert atmosphere giving final decomposition products, which are two modifications of nanosized metallic cobalt (hcp-15 nm, fcc-250 nm) and CoO (55 nm). The redox reaction results in N2as an ammonia oxidation product. The decomposition intermediate is a cobalt(II) compound, Co2O1,14+δ(SO4)0.86(δ = the oxygen surplus due to the presence of 2.8% of Co(III) ion). The same reaction in air atmosphere resulted in Co2O1.25+δ(SO4)0.75(δ = the oxygen surplus due to the presence of 5.3% of Co(III) ion (compound3a). Compound3ais oxidized in air at 793 °C into Co3O4. The compound3aexhibits catalytic activity in photodegradation in Congo red. The photodegradation process follows pseudo-first-order kinetic (kapp = 1.0 and 7.0. at pH = 3.4 and 5.25, respectively).
Flexible here-and-now decisions for two-stage multi-objective optimization: method and application to energy system design selection
Authors: Hollermann Dinah Elena , Goerigk Marc , Hoffrogge Dörthe Franzisca , Hennen Maike , Bardow André
Published: July 2020

The synthesis of energy systems is a two-stage optimization problem where design decisions have to be implemented here-and-now (first stage), while for the operation of installed components, we can wait-and-see (second stage). To identify a sustainable design, we need to account for both economical and environmental criteria leading to multi-objective optimization problems. However, multi-objective optimization does not lead to one optimal design but to multiple Pareto-efficient design options in general. Thus, the decision maker usually has to decide manually which design should finally be implemented. In this paper, we propose the flexible here-and-now decision (flex-hand) approach for automatic identification of one single design for multi-objective optimization. The approach minimizes the distance of the Pareto front based on one fixed design to the Pareto front allowing multiple designs. Uncertainty regarding parameters of future operations can be easily included through a robust extension of the flex-hand approach. Results of a real-world case study show that the obtained design is highly flexible to adapt operation to the considered objective functions. Thus, the design provides an energy system with the ability to adapt to a changing focus in decision criteria, e.g., due to changing political aims.
10th Anniversary of a Two-Stage Design in Bioequivalence. Why Has it Still Not Been Implemented?
Authors: Kaza Michał , Sokolovskyi Alexander , Rudzki Piotr J.
Published: July 2020

Purpose

In 2010 the European Medicines Agency allowed a two-stage design in bioequivalence studies. However, in the public domain there are mainly articles describing the theoretical and statistical base for the application of the two-stage design. One of the reasons seems to be the lack of practical guidance for the Sponsors on when and how the two-stage design can be beneficial in bioequivalence studies.

Methods

Different variants with positive and negative outcomes have been evaluated, including a pivotal study, pilot + pivotal study and two-stage study. The scientific perspective on the two-stage bioequivalence study has been confronted with the industrial one.

Results

Key information needed to conduct a bioequivalence study – such as in vitro data and pharmacokinetics – have been listed and organized into a decision scheme. Advantages and disadvantages of the two-stage design have been summarized.

Conclusion

The use of the two-stage design in bioequivalence studies seems to be a beneficial alternative to the 2 × 2 crossover study. Basic information on the properties of the active substance and the characteristics of the drug form are needed to make an initial decision to carry out the two-stage study.
CEO chairman controversy: evidence from the post financial crisis period
Authors: Gontarek Walter , Belghitar Yacine
Published: July 2020

Regulators generally discourage bank CEOs also holding the role of board Chairman, as this governance structure can hinder independent decision-making and effective risk oversight. This study examines the issue of CEO Duality, identifying a positive relation to greater risk-taking across a battery of sensitivity tests. In further analysis, the study controls for differences in supervisory monitoring levels to examine its impact. Banks led by CEO Chairmen which are subject to lower levels of supervision continue to report a robust association to risk-taking, as before. However, this association dissipates for banks which are subject to heightened supervisory monitoring. These findings indicate that agency costs related to Duality may be moderated by greater regulation. This paper weighs-in on the controversy relating to a single contentious governance structure (i.e., CEO Duality), thus informing boards, regulators and researchers of the need to consider the overall interplay of monitoring mechanisms.
Quantifying the higher-order influence of scientific publications
Authors: Franceschet Massimo , Colavizza Giovanni
Published: July 2020

Citation impact is commonly assessed using direct, first-order citation relations. We consider here instead the indirect influence of publications on new publications via citations. We present a novel method to quantify the higher-order citation influence of publications, considering both direct, or first-order, and indirect, or higher-order citations. In particular, we are interested in higher-order citation influence at the level of disciplines. We apply this method to the whole Web of Science data at the level of disciplines. We find that a significant amount of influence—42%—stems from higher-order citations. Furthermore, we show that higher-order citation influence is helpful to quantify and visualize citation flows among disciplines, and to assess their degree of interdisciplinarity.
Telling the story of solar energy meteorology into the satellite era by applying (co-citation) reference publication year spectroscopy
Authors: Scheidsteger Thomas , Haunschild Robin
Published: July 2020

Studying the history of research fields by analyzing publication records and topical and/or keyword searches with reference publication year spectroscopy (RPYS) has been introduced as a powerful tool to identify the corresponding root publications. However, for some research fields (e.g., rather new and interdisciplinary fields) like solar energy meteorology, encompassing such research fields via a keyword- or topic-based search query is not feasible to get a reasonably exhaustive publication set. Therefore, we apply its variant RPYS-CO to all publications co-cited with two highly important marker papers, using the cited references explorer for inspecting the RPYS-CO results. We obtain two lists of seminal papers, which are able to adequately tell us the story of solar energy meteorology up to the 1990s, respectively in its subfield using satellite-based methods for solar irradiance estimation even to very recent years. Consequently, we recommend this method to gain valuable insights in (new) research fields.
Education for Loneliness as a Consequence of Moral Decision-Making: An Issue of Moral Virtues
Authors: Horowski Jarosław
Published: July 2020

The direct reference point for these analyses is the process of making moral decisions, but a particular point of interest is the difficulty associated with making decisions when acting subjects are aware that their choice of moral good can lead to the breakdown of relationships with those close to them (family members or friends) or to their exclusion from the group(s) that have been most important to them so far in their lives, consequently causing them to experience loneliness. This difficulty is a challenge for education, which in supporting the moral development of a maturing person should prepare her/him for choosing moral good even if this requires personal sacrifices. In these analyses, assuming that knowledge of moral good is not sufficient for morally good actions, I refer mainly to the virtues of character that facilitate making morally good decisions and I seek the answer to the question: what character traits (moral virtues) should be shaped in maturing persons, so that as adults they can resist moral evil, even when this will clearly lead to the experience of loneliness? I propose these character traits as expressing moral virtues—especially the cardinal virtues of prudence, justice, temperance and fortitude (neo-Thomistic approach). In this way, I join in the discussion relating to the teleology of education. I do not touch on the methodology of education, however. The argument is presented in two parts. In the first, I introduce the problem of decision-making implying consent to loneliness. In the second, I reflect on the characteristics of a person who is capable of making such a decision.
Continuous Dynamics Related to Monotone Inclusions and Non-Smooth Optimization Problems
Authors: Csetnek Ernö Robert
Published: July 2020

The aim of this survey is to present the main important techniques and tools from variational analysis used for first and second order dynamical systems of implicit type for solving monotone inclusions and non-smooth optimization problems. The differential equations are expressed by means of the resolvent (in case of a maximally monotone set valued operator) or the proximal operator for non-smooth functions. The asymptotic analysis of the trajectories generated relies on Lyapunov theory, where the appropriate energy functional plays a decisive role. While the most part of the paper is related to monotone inclusions and convex optimization problems in the variational case, we present also results for dynamical systems for solving non-convex optimization problems, where the Kurdyka-Łojasiewicz property is used.
Gender differences in the susceptibility of hospital-acquired acute kidney injury: more questions than answers
Authors: Schiffl Helmut
Published: July 2020

Hospital-acquired acute kidney injury (HA-AKI) is a heterogeneous renal syndrome which occurs in different clinical settings. It is characterized by multiple aetiologies, various pathogeneses and unpredictable outcomes. HA-AKI, once predominantly viewed as a self-limited and reversible short-term condition, is now recognized as a harbinger for chronic kidney disease and a cause of long-term morbidity with an increased risk of cardiovascular, renal and cancer mortality. Recent clinical studies contradict the generally held belief that female sex is a risk factor for HA-AKI. They show, consistent with basic research performed with experimental models of AKI, that only male sex is associated with HA-AKI. The presence of testosterone, more likely than the absence of estrogen, plays a critical role in sex differences in the susceptibility of ischemia/reperfusion kidney injury. The conflicting data in epidemiological studies related to sex as susceptibility variable for human AKI, underscore the need for more rigorous, well designed observational studies taking into account the menopausal status and hormone therapy.
The role of individual personality in conceptualizing and measuring group characteristics
Authors: Deckers Marius , Altmann Tobias , Roth Marcus
Published: July 2020

In previous research, group characteristics have often been measured without taking the individual perspective of the group members into account. Therefore, the influence of individual personality (and other individual-level characteristics) on group characteristic ratings beyond the influence of the actual group remains largely unexplored. Additionally, some studies use group means of individual personality as group characteristics, however, evidence for interrelations or differences between these approaches has not yet been empirically based. In the present study, we employed a sample of 301 individuals from 54 teams, all of which rated both characteristics of themselves and their teams. By averaging both self-ratings and group-ratings within each team, we were able to compare both approaches to group characteristics and found them to likely measure unrelated constructs. We also found influences of individual Extraversion and Agreeableness from the HEXACO model on direct group characteristic ratings beyond the influence of the actual group. Years of work experience and work strain operationalized through burnout symptoms did not predict group characteristic ratings beyond the influence of the actual group and individual personality. Our findings imply that individual ratings of a group characteristic are influenced to a larger degree by the raters’ individual perspectives than by the presumed actual group characteristic itself. Further implications for research applying individual personality to groups are discussed.
Feeding the food insecure in Britain: learning from the 2020 COVID-19 crisis
Authors: Barker Margo , Russell Jean
Published: July 2020

The lockdown in Britain has rendered a large proportion of the population economically vulnerable and has at least quadrupled demand for emergency food relief. This paper looks critically at response to the crisis from the government and the voluntary sector with respect to provision of emergency food. In doing so, it has exposed gaps in understanding of the vagaries of the food supply for certain population groups and systemic weaknesses in the current system of emergency food aid. We make recommendations for healthier governmental capacity to react to a food security crisis, better relationships between the government and the voluntary sector, and further research into the dietary constraints of the precariate. Importantly, the social system needs to be responsive to short-term changes in people’s income if people are not to fall into food insecurity.
Climate Change Mitigation through Land Use on Rewetted Peatlands – Cross-Sectoral Spatial Planning for Paludiculture in Northeast Germany
Authors: Tanneberger Franziska , Schröder Christian , Hohlbein Monika , Lenschow † Uwe , Permien Thorsten , Wichmann Sabine , Wichtmann Wendelin
Published: July 2020

Drainage of peatlands causes severe environmental damage, including high greenhouse gas emissions. Peatland rewetting substantially lowers these emissions. After rewetting, paludiculture (i.e. agriculture and forestry on wet peatlands) is a promising land use option. In Northeast Germany (291,361 ha of peatland) a multi-stakeholder discussion process about the implementation of paludiculture took place in 2016/2017. Currently, 57% of the peatland area is used for agriculture (7% as arable land, 50% as permanent grassland), causing greenhouse gas emissions of 4.5 Mt CO2eq a−1. By rewetting and implementing paludiculture, up to 3 Mt CO2eq a−1from peat soils could be avoided. To safeguard interests of both nature conservation and agriculture, the different types of paludiculture were grouped into ‘cropping paludiculture’ and ‘permanent grassland paludiculture’. Based on land legislation and plans, a paludiculture land classification was developed. On 52% (85,468 ha) of the agriculturally used peatlands any type of paludiculture may be implemented. On 30% (49,929 ha), both cropping and permanent grassland paludiculture types are possible depending on administrative check. On 17% (28,827 ha), nature conservation restrictions allow only permanent grassland paludiculture. We recommend using this planning approach in all regions with high greenhouse gas emissions from drained peatlands to avoid land use conflicts.
LARGE-LOSS BEHAVIOR OF CONDITIONAL MEAN RISK SHARING
Authors: Denuit Michel , Robert Christian Y.
Published: July 2020

We consider the conditional mean risk allocation for an insurance pool, as defined by Denuit and Dhaene (2012). Precisely, we study the asymptotic behavior of the respective relative contributions of the participants as the total loss of the pool tends to infinity. The numerical illustration in Denuit (2019) suggests that the application of the conditional mean risk sharing rule may produce a linear sharing in the tail of the total loss distribution. This paper studies the validity of this empirical finding in the class of compound Panjer–Katz sums consisting of compound Binomial, compound Poisson, and compound Negative Binomial sums with either Gamma or Pareto severities. It is demonstrated that such a behavior does not hold in general since one term may dominate the other ones conditional of large total loss.
National Electoral Thresholds and Disproportionality
Authors: Kalandrakis Tasos , Rueda Miguel R.
Published: July 2020

We model the conditional distribution of seats given vote shares induced by national electoral systems using a stochastic threshold of representation and a disproportionality parameter that regulates allocation for parties above the threshold. We establish conditions for the parameters of this model to be identified from observed seats/votes data, and develop a Maximum a Posteriori Expectation-Maximization (MAP-EM) algorithm to estimate them. We apply the procedure to 116 electoral systems used in 417 elections to the lower house across 36 European countries since WWII. We reject a test of model fit in only 5 of those systems, while a simpler model without thresholds is rejected in favor of our estimated model in 49 electoral systems. We find that the two modal electoral system configurations involve higher thresholds with seat allocation for parties exceeding thresholds that does not statistically differ from perfectly proportional allocation (32.76% of all systems); and systems for which we cannot reject the absence of a national threshold but exhibit disproportional seat allocation for parties eligible for seats (38.79% of all systems). We also develop procedures to test for significant changes in electoral institutions and/or the distribution of seats.
Case Nos. 2 BvR 2115/01, 2 BvR 2132/01, & 2 BvR 348/03.60 Neue Juristische Wochenschrift 499 (2007)
Authors: Bodansky Daniel , Gärditz Klaus Ferdinand
Published: July 2020

Case Nos.2 BvR 2115/01, 2 BvR 2132/01, & 2 BvR 348/03.60 Neue Juristische Wochenschrift 499 (2007). At .

Bundesverfassungsgericht (Federal Constitutional Court of Germany), September 19, 2006.

On September 19, 2006, the Federal Constitutional Court of Germany (Bundesverfassungsgericht) held in jointly decided Case Nos. 2 BvR 2115/01, 2 BvR 2132/01, & 2 BvR 348/03 that a failure to provide consular information to foreign nationals pursuant to Article 36 of the Vienna Convention on Consular Relations (VCCR) violates the guarantee of a fair trial as provided by the German Constitution (Grundgesetz). The result is in contrast to a recent U. S. Supreme Court decision in Sanchez-Llamas v. Oregon, a strikingly similar case.

The defendants, two nationals of Turkey and two of Serbia-Montenegro, were arrested in the course of different criminal investigations. They were informed of their rights as defendants as guaranteed by Germany's law of criminal procedure. The prosecuting authorities failed, however, to provide information on the defendants’ right to contact the consular staffs of their own countries in compliance with the VCCR. Three defendants were found guilty of murder and sentenced to lifetime imprisonment by the district court (Landgericht) of Braunschweig. The district court of Hamburg found the fourth defendant guilty of a robbery that resulted in the death of a victim, and sentenced him to eleven years’ imprisonment. Since the defendants refused to make statements, the criminal courts relied, inter alia, on the testimony of the police officers questioning the defendants after their various arrests. During the subsequent criminal proceedings, the defendants, presumably out of ignorance, made no attempt to invoke their consular rights, and the district courts seemed to be equally unaware of those rights.
The Evolving International Human Rights System
Authors: Buergenthal Thomas
Published: July 2020

Few, if any, branches of international law have undergone such dramatic growth and evolution as international human rights in the one hundred years since the founding of the American Society of International Law. This branch of international law did not really come into its own until after World War II. Before then, what today we would broadly characterize as human rights law consisted of diffuse or unrelated legal principles and institutional arrangements that were in one way or another designed to protect certain categories or groups of human beings. Included in this mix prior to World War I were state responsibility for injuries to aliens, international humanitarian law (as we know it today), the protection of minorities, and humanitarian intervention.
Land Feuds and Their Solutions: Finding International Law Beyond the Tribunal Chamber
Authors: Ratner Steven R.
Published: July 2020

The resolution of conflicting claims to land has long stood at the heart of the project of international law. Indeed, the encounter between the order envisaged by advocates of the law of nations and what Georges Scelle called the “obsession with territory” has been a defining struggle for our field, demonstrating to some its promise and to others its futility. Much, perhaps even most, legal scholarship on this subject over the last century has focused on adjudication by ad hoc tribunals or standing courts, in which jurists have derived and invoked hallowed principles that enabled them to draw lines—across mountains, deserts, rivers, and human settlements—where mere politicians had never succeeded. The doctrines on territorial sovereignty emanating from these decisions suggested a bright future for law. Yet a more pessimistic appraisal would see a darker image, one characterized by war—interstate, colonial, and civil—and territorial settlement whose lines have reflected power and politics, but surely not norms. Adjudications could be viewed as a sideshow for addressing small-scale conflicts, the results dictated more by a desire to appease both parties than by reasoning toward some principled solution.
Distribution and impact of invasive alien plant species in Bardia National Park, western Nepal
Authors: Bhatta Suneeta , Joshi Laxmi Raj , Shrestha Bharat Babu
Published: July 2020

Invasive alien plant species (IAPS) are spreading into protected areas worldwide; however, knowledge of these invasions and their impacts in Nepal’s protected areas is poor. Here, the spatial distribution pattern of IAPS in Bardia National Park (BNP), Nepal, was analysed using roadside surveys and grid sampling. The impacts of the most abundant IAPS, Lantana camara, on plant communities were analysed by comparing 60 pairs of non-invaded and invaded quadrats. Twelve IAPS, including two of the most prolific species globally, L. camara and Chromolaena odorata, were recorded from BNP. The Karnali floodplain in the south-western region of the park, a prime habitat of one-horned rhinoceros, was highly invaded by the IAPS. Tree canopy and distance to road, river and settlement were the major factors affecting IAPS occurrence. Lantana camara modified plant community structure and significantly reduced plant species richness and diversity; species richness of native plants was reduced to less than half in invaded plots. Plant invasions and impacts on native plant diversity have been increasing in BNP. We recommend management interventions involving immediate eradication of C. odorata and other species with single satellite populations and control measures for other widespread species such as L. camara and Ageratum houstonianum.
Crystal structure and X-ray absorption spectroscopy of trimethylarsine oxide dihydrate, (CH3)3AsO⋅2H2O
Authors: Reid Joel W. , Kaduk James A. , Blanchard Peter E. R.
Published: July 2020

The crystal structure of trimethylarsine oxide dihydrate, (CH3)3AsO⋅2H2O, (TMAO dihydrate) has been solved using parallel tempering with the FOX software package and refined using synchrotron powder diffraction data obtained from beamline 08B1-1 at the Canadian Light Source. Rietveld refinement, performed with the software package GSASII, yielded orthorhombic lattice parameters of a = 13.3937(4) Å, b = 9.53025(30) Å, and c = 11.5951(3) Å (Z = 8, space group Pbca). The Rietveld refined structure was compared with density functional theory calculations performed with VASP and shows reasonable agreement. Arsenic K-edge X-ray absorption spectroscopy analysis also revealed additional information on the electronic structure of the arsenic atom within the TMAO dihydrate structure.
Andreas’ Device: The Labyrinth and Hidden Symmetries
Authors: Mcmorris Mark
Published: July 2020

This article is in two parts: a series of drawings depicting walls, and a series of lyrical or imaginative commentaries on walls. The drawings show walls in multifarious forms, more or less abstract, more or less figurative, constrained by geometrical regularity. The format of presentation elicits the perception of rhythm in the lateral survey of the drawings, which in turn suggests the operation of forms comparable to those encountered in the perusal of poetic language organized over many pages in serial verse. In particular, comprising a visual series, the drawings may be discussed in terms of poetic devices such as echo, verse-line, and meter, and their repeating elements. Besides verbal art, the drawings also function as a schematic representation of walled edifices that embody the ratios and measures of symmetry in physical architecture (a cathedral interior, a city block, a Daedalian labyrinth, for example). Mindful of both analogies – with poetic language and physical architecture – the commentaries attempt reflection on the experience of symmetry in the drawings.
The effect of an instantaneous dependency rate on the social equitability of hybrid PAYG public pension schemes
Authors: Torricelli Lorenzo
Published: July 2020

The defined convex combination (DCC) pay-as-you-go public pension systems recently introduced in the literature are a form of hybridization between defined benefit (DB) and defined contribution (DC) designed to maintain intergenerational social equitability by reacting to demographic shocks in an optimal way. In this paper, we augment DCC schemes with the assumption that the dependency ratio between pensioners and workers is driven by an exogenously modelled instantaneous stochastic rate of change. This assumption enjoys support from the empirical data and allows explicit solutions for the contribution and replacement rate processes which make transparent the nature of the dynamic evolution of a DCC system, as well as the role of the variables involved. The analysis of intergenerational social equitability measures under the assumption of an instantaneous dependency rate confirms the view expressed in previous literature that neither DB nor DC achieves social fairness, and that DCC plans have the potential to improve on both. We perform a calibration test, and our findings seem to indicate that in ageing economies the DC system might indeed be superior to the DB one in terms of intergenerational fairness.
Theresienstadt: A Geographical Picture of Transports, Demography, and Communicable Disease in a Jewish Camp-Ghetto, 1941–45
Authors: Smallman-Raynor Matthew R. , Cliff Andrew D.
Published: July 2020

The Nazi ghetto system was one of the principal vehicles for the persecution of Jewish and other peoples in German-occupied Europe in World War II. Transport and confinement—twin pillars of the ghetto system—were intrinsically geographical matters that operated on scales from the international to the local and that shaped the demographic and epidemiological character of ghettos across Eastern Europe. This article uses geographical techniques of map-based visualization and spatial analysis to portray the demographic and epidemic history of the Nazi “model” camp-ghetto at Theresienstadt (Terezín) in the former German Protectorate of Bohemia and Moravia, 1941–45. Our study reconstructs the space-time pattern and demographic structure of transports of Jewish prisoners to the ghetto and their association with substantial outbreaks of communicable diseases in the ghetto. The study highlights the importance of a geographical approach to an understanding of the demographic and public health impacts of both the Holocaust and other genocidal events.
Development of new predictive equations for basal metabolic rate in	Iranian healthy adults: negligible effect of sex
Authors: Nikooyeh Bahareh , Shariatzadeh Nastaran , Kalayi Ali , Zahedirad Maliheh , Neyestani Tirang R.
Published: July 2020

Abstract. Some studies have reported inaccuracy of predicting basal metabolic rate (BMR) by using common equations for Asian people. Thus, this study was undertaken to develop new predictive equations for the Iranian community and also to compare their accuracy with the commonly used formulas. Anthropometric measures and thyroid function were evaluated for 267 healthy subjects (18–60 y). Indirect calorimetry (InCal) was performed only for those participants with normal thyroid function tests (n = 252). Comparison of predicted RMR (both kcal/d and kcal.kg.wt−1.d−1) using current predictive formulas and measured RMR revealed that Harris-Benedict and FAO/WHO/UNU significantly over-estimated and Mifflin-St. Jeor significantly under-estimated RMR as compared to InCal measurements. In stepwise regression analysis for developing new equations, the highest r2 (=0.89) was from a model comprising sex, height and weight. However, further analyses revealed that unlike the subjects under 30 y, the association between age and the measured RMR in subjects 30 y and plus was negative (r = −0.241, p = 0.001). As a result, two separate equations were developed for these two age groups. Over 80 percent of variations were covered by the new equations. In conclusion, there were statistical significant under- and over-estimation of RMR using common predictive equations in our subjects. Using the new equations, the accuracy of the calculated RMR increased remarkably.
Associations of movement behaviors and body mass index: comparison between a report-based and monitor-based method using Compositional Data Analysis
Authors: Kim Youngwon , Burns Ryan D. , Lee Duck-chul , Welk Gregory J.
Published: July 2020

Background/objectives

Evidence on the associations between lifestyle movement behaviors and obesity has been established without taking into account the time-constrained nature of categorized, time-based lifestyle behaviors. We examined the associations of sleep, sedentary behavior (SED), light-intensity physical activity (LPA), and moderate-to-vigorous PA (MVPA) with body mass index (BMI) using Compositional Data Analysis (CoDA), and compared the associations between a report-based method (24-h Physical Activity Recall; 24PAR) and a monitor-based method (SenseWear Armband; SWA).

Subjects/methods

Replicate data from a representative sample of 1247 adults from the Physical Activity Measurement Survey (PAMS) were used in the study. Participants completed activity monitoring on two randomly selected days, each of which required wearing a SWA for a full day, and then completing a telephone-administered 24PAR the following day. Relationships among behavioral compositional parts and BMI were analyzed using CoDA via multiple linear regression models with both 24PAR and SWA data.

Results

Using 24PAR, time spent in sleep (γ = −3.58, p = 0.011), SED (γ = 3.70, p = 0.002), and MVPA (γ = −0.53, p = 0.018) was associated with BMI. Using SWA, time spent in sleep (γ = −5.10, p < 0.001), SED (γ = 8.93, p < 0.001), LPA (γ = −3.12, p < 0.001), and MVPA (γ = −1.43, p < 0.001) was associated with BMI. The SWA models explained more variance in BMI (R2 = 0.28) compared with the 24PAR models (R2 = 0.07). The compositional isotemporal substitution models revealed reductions in BMI when replacing SED by MVPA, LPA (not with 24PAR) or sleep for both 24PAR and SWA, but the effect estimates were larger with SWA.

Conclusions

Favorable levels of relative time spent in lifestyle movement behaviors were, in general, associated with decreased BMI. The observed associations were stronger using the monitor-based SWA method compared with the report-based 24PAR method.
Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML
Authors: Toda Jun , Ichii Michiko , Oritani Kenji , Shibayama Hirohiko , Tanimura Akira , Saito Hideaki , Yokota Takafumi , Motooka Daisuke , Okuzaki Daisuke , Kitai Yuichi , Muromoto Ryuta , Kashiwakura Jun-ichi , Matsuda Tadashi , Hosen Naoki , Kanakura Yuzuru
Published: July 2020

The family of signal-transducing adapter proteins (STAPs) has been reported to be involved in a variety of intracellular signaling pathways and implicated as transcriptional factors. We previously cloned STAP-2 as a c-Fms interacting protein and explored its effects on chronic myeloid leukemia (CML) leukemogenesis. STAP-2 binds to BCR-ABL, upregulates BCR-ABL phosphorylation, and activates its downstream molecules. In this study, we evaluated the role of STAP-1, another member of the STAP family, in CML pathogenesis. We found that the expression of STAP-1 is aberrantly upregulated in CML stem cells (LSCs) in patients’ bone marrow. Using experimental model mice, deletion of STAP-1 prolonged the survival of CML mice with inducing apoptosis of LSCs. The impaired phosphorylation status of STAT5 by STAP-1 ablation leads to downregulation of antiapoptotic genes, Bcl-2 and Bcl-xL. Interestingly, transcriptome analyses indicated that STAP-1 affects several signaling pathways related to BCR-ABL, JAK2, and PPARγ. This adapter protein directly binds to not only BCR-ABL, but also STAT5 proteins, showing synergistic effects of STAP-1 inhibition and BCR-ABL or JAK2 tyrosine kinase inhibition. Our results identified STAP-1 as a regulator of CML LSCs and suggested it to be a potential therapeutic target for CML.
Insights into the dynamics between viruses and their hosts in a hot spring microbial mat
Authors: Jarett Jessica K , Džunková Mária , Schulz Frederik , Roux Simon , Paez-Espino David , Eloe-Fadrosh Emiley , Jungbluth Sean P , Ivanova Natalia , Spear John R , Carr Stephanie A , Trivedi Christopher B , Corsetti Frank A , Johnson Hope A , Becraft Eric , Kyrpides Nikos , Stepanauskas Ramunas , Woyke Tanja
Published: July 2020

Our current knowledge of host–virus interactions in biofilms is limited to computational predictions based on laboratory experiments with a small number of cultured bacteria. However, natural biofilms are diverse and chiefly composed of uncultured bacteria and archaea with no viral infection patterns and lifestyle predictions described to date. Herein, we predict the first DNA sequence-based host–virus interactions in a natural biofilm. Using single-cell genomics and metagenomics applied to a hot spring mat of the Cone Pool in Mono County, California, we provide insights into virus–host range, lifestyle and distribution across different mat layers. Thirty-four out of 130 single cells contained at least one viral contig (26%), which, together with the metagenome-assembled genomes, resulted in detection of 59 viruses linked to 34 host species. Analysis of single-cell amplification kinetics revealed a lack of active viral replication on the single-cell level. These findings were further supported by mapping metagenomic reads from different mat layers to the obtained host–virus pairs, which indicated a low copy number of viral genomes compared to their hosts. Lastly, the metagenomic data revealed high layer specificity of viruses, suggesting limited diffusion to other mat layers. Taken together, these observations indicate that in low mobility environments with high microbial abundance, lysogeny is the predominant viral lifestyle, in line with the previously proposed “Piggyback-the-Winner” theory.