bluuebunny/crossref_metadata_2025 huggingface dataset:
1486-PUB: Single-Toe Necrosis over Diabetic Foot Ulcer (DFU) : Amputation Surgery at Bedside by a Diabetologist or in the Operating Room by a Surgeon
Authors: FÉRON FLORINE , RIVELINE JEAN-PIERRE , GAUTIER JEAN-FRANÇOIS , KEVORKIAN JEAN-PHILIPPE
Published: June 2022

Single toe necrosis complicating DFU requires an amputation performed in the operating room by a surgeon (ORAS) . Bedside amputation by a diabetologist (BAD) complying with the surgical rules might be an option in case of disagreement with the surgeon about the amputation level (major favored by the surgeon) and/or an anesthetic contraindication. In our monocentric, retrospective study, we assessed the one year prognosis (healing rate without extra surgery) of a single toe necrosis amputation over DFU performed by a diabetologist or a surgeon. Amputation levels (transphalangeal, TPA, metatarsophalangeal disarticulation, MPD, single transmetatarsal, TMA) were decided by our multidisciplinary team. Out of 7patients admitted with DFU (05.2016-10.2020) , 57 (8%) were included because of single toe necrosis (BAD n=33, 58%; ORAS n=24, 42%) . Amputation levels TPA, MPD, TMA were respectively 26, 47, 27%. The median duration of follow-up was 28 months. Patients characteristics were non statistically different between groups except for the dorsal arch permeability: males 74%; median age 64y; Type 2 Diabetes Mellitus (DM) 97%; median DM duration 17y. The rate of permeable dorsal arch was significantly lower in the BAD group (45% vs. 75%, p=0.03) . Single TMA rate was significantly higher in the ORAS group (50% vs. 9%, p=0.001) . The one year healing rate without extra surgery was statistically different between the two groups (BAD 58% vs. ORAS 83%, p=0.05) . The need for extra surgery was significantly higher in the BAD group (42% vs. ORAS 13%, p=0.02) . The overall mortality was non significantly different between groups (BAD 21% vs. ORAS 4%, p=0.12) . For a single toe necrosis over DFU, in patients with a high risk for a circumscribed toe amputation failure as stated by the surgeon, the results of bedside amputation performed by a diabetologist invalidated this unfavorable prognosis in most cases.

Disclosure

F.Féron: None. J.Riveline: None. J.Gautier: Other Relationship; Novo Nordisk, Sanofi, Speaker's Bureau; Eli Lilly and Company. J.Kevorkian: None.
1488-PUB: Did New York City Diabetes Prevention Programs Suffer or Succeed during COVID-Pandemic Lockdowns?
Authors: APFELBAUM LEORA , SMITH ELEANOR , HORLYCK-ROMANOVSKY MARGRETHE F.
Published: June 2022

Pandemic restrictions may have affected in-person health education such as the CDC’s Diabetes Prevention Program (DPP) . We interviewed staff from New York City (NYC) DPPs to a) document if/how DPPs adapted and served participants during pandemic lockdowns, and b) identify successes and challenges to operating remotely. Interviewees were lifestyle coaches and DPP coordinators representing a public hospital, a national weight loss program, a healthcare center, a community based organization, a health insurance company, a faith-based DPP, and a network of federally qualified health centers. DPPs served participants in Manhattan, Brooklyn, Queens, and the Bronx. Zoom interviews (1hr) were recorded and transcribed. Interviewees received a $50 gift card.DPP host organizations continued to provide DPP services during the pandemic and experienced a number of successes and challenges (Table) .

NYC DPPs suffered greatly during COVID-lockdowns and limits on social gathering because they and their participants were unprepared for virtual classes. However, most were successful due to resilient, dedicated, and extraordinarily creative staff. The pandemic highlighted opportunities for successful virtual DPPs in the urban setting, and the need for more robust funding mechanisms, staff support, and technical assistance to ensure sustainability and scalability of the DPP.

Disclosure

L.Apfelbaum: None. E.Smith: None. M.F.Horlyck-romanovsky: None.

Funding

Brooklyn College Faculty startup funds
1489-PUB: Know Diabetes by Heart Campaign and Project Dulce: A Culturally Tailored Mobile-Based Self-Management Program Supports High-Risk Populations with Diabetes to Manage Cardiovascular Disease Risk
Authors: RUIZ MONICA , FORTMANN ADDIE L. , SANDOVAL HALEY , PHILIS-TSIMIKAS ATHENA , CHICHMARENKO MARIYA , BAGSIC SAMANTHA R. , BOYER JOSHUA
Published: June 2022

Diabetes, high blood pressure, and obesity are major risk factors for cardiovascular disease (CVD) . Access to and awareness of health education programming is often low in ethnic/racial minorities and individuals of low socioeconomic status experience a higher prevalence of T2D, hypertension, CVD and stroke. Additionally, underserved, at-risk patients face barriers to accessing traditional in-person diabetes self-management education and support (DSME/S) due to transportation, caregiving, and work conflicts. To address this gap, the ADA’s Know Diabetes by Heart (KDBH) initiative partnered with Project Dulce, an evidence-based culturally and linguistically modified DSME/S program to overlay an innovative digital approach to diabetes support programming and resources in the community. In response to COVID-restrictions, Project Dulce sessions integrating KDBH content were delivered via telehealth group sessions and text messaging to encourage heart healthy self-management behaviors. Pre/post surveys assessed knowledge and self-management, and clinical metrics were evaluated via electronic health records. The KDBH/Project Dulce DSME/S program was delivered to 5 health systems in California: 2 Federally Qualified Health Centers, 2 County health clinics and 1 large community-based health system near the US/Mexico border. Of the N=553 who received KDBH/Project Dulce education, 47% were White, 36% Hispanic, 14% African American, Asian, Native American, Pacific Islander, and 3% other. Of all enrollees, 58% were female, and 15% were </= 45 y/o, 50% were 46-65 y/o and 35% were >/= 66 y/o. Participant feedback indicated acceptance of both the group virtual and texting programs. Findings demonstrate the feasibility of disseminating important heart healthy interventions to diverse ethnic/racial minority groups via a variety of digital and telehealth methods.

Disclosure

M.Ruiz: n/a. A.L.Fortmann: Consultant; Ascensia Diabetes Care, Employee; Dexcom, Inc. H.Sandoval: None. A.Philis-tsimikas: Advisory Panel; Bayer AG, Novo Nordisk, Research Support; Lilly Diabetes, National Institute of Diabetes and Digestive and Kidney Diseases, Novo Nordisk, Viking Therapeutics. M.Chichmarenko: None. S.R.Bagsic: None. J.Boyer: None.

Funding

American Diabetes Association/KDBH;
1492-PUB: In Silico Modeling of the Performance of a Novel Closed-Loop Algorithm Using the UVA/PADOVA Type 1 Diabetes Simulator
Authors: DEDESHKO ALEXEY J. , FEDOTOV VITALY , SIMIC AMRA , THIVOLET CHARLES , MADER JULIA K.
Published: June 2022

AIAPS is a novel smartphone-based closed-loop algorithm in development that can be combined with any insulin pump and continuous glucose monitor. AIAPS strives to reduce burden of diabetes by requiring only limited input and by handling unannounced meals. Prior to launching the clinical research program in-silico modelling of the most recent features was performed. The objective of this study was to evaluate the AIAPS performance using the UVA/PADOVA Type 1 Diabetes (T1D) Simulator in people with T1D.

AIAPS was used in the in-silico population of 33 subjects (children, adolescents, and adults) of the UVA/PADOVA T1D Simulator. Upon initialisation, 5 min CGM data, body weight, average daily insulin dose and sex for each person was available. To model a scenario with limited information for each individual upon initialization, no data on basal insulin profiles (BIP) , carbohydrate-to-insulin ratio (CR) and insulin sensitivity factor (ISF) were put into AIAPS. Additionally, no information on meals (time or carbohydrate content) were put into AIAPS. The following scenario was modelled: 84 days of closed-loop therapy without user interaction and with variable routine conditions representing the duration of the planned clinical study.

Data on glycemic control for the three age groups over the 84 days are shown in table 1. Modelling included 2-5 unannounced meals with a random schedule and carbohydrate content of 130-250 g per day.

In an in-silico model the AIAPS closed-loop system exceeded current glycemic targets with a TIR >70% and a TBR <4% in all age groups without user interaction or input of BIP, CR and ISF upon initialization. The next step includes testing the AIAPS performance in a randomized controlled trial.

Table 1 - Glycemic control for the three age groups. Data are mean standard deviation.

Disclosure

A.J.Dedeshko: Stock/Shareholder; AI APS France. V.Fedotov: Stock/Shareholder; AIAPS France. A.Simic: None. C.Thivolet: Board Member; Insulet Corporation, Medtronic, Research Support; Abbott Diabetes, Lilly Diabetes, Novo Nordisk A/S, Sanofi. J.K.Mader: Advisory Panel; Abbott Diabetes, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Medtronic, Merck Sharp & Dohme Corp., Novo Nordisk A/S, Roche Diabetes Care, Sanofi-Aventis Deutschland GmbH, Speaker's Bureau; Abbott Diabetes, Eli Lilly and Company, Medtronic, Merck Sharp & Dohme Corp., Novo Nordisk A/S, Roche Diabetes Care, Sanofi-Aventis Deutschland GmbH, Servier Laboratories, Stock/Shareholder; decide Clinical Software GmbH.
1493-PUB: Effects of Semaglutide on Body Composition in Obese and Diabetic Patients Attended in Internal Medicine Wards
Authors: GOMEZ JUANA CARRETERO , LORIDO JOSE CARLOS AREVALO , MARTINEZ LUIS GARCIA
Published: June 2022

Aim: Analyze changes on body composition in obese and T2DM patients treated with semaglutide.

Methods: Observational, prospective study. Body composition was studied by bioimpedance (BIO) . Changes were evaluated over a median of 26 wk. Paired Wilcoxon test was used to analyze the differences.

Results: 54 patients (53.7% women, mean age 53.5+/-21yr) . Table 1 shows data at baseline and follow up. We found a reduction in body weigh (-3.5 kg (2.7-4.3) p=0.00) mainly related to fat mass (-6 kg (4.1-8.5) p=0.00) with a little loss of lean (-2.6 (1.3-4.1) p=0.0004) and muscle mass (-0.8 (0.0004-1.6) p=0.04) (Fig 1)

Discussion: Sarcopenic Obesity is highly prevalent in T2DM associated with comorbidities like HBP, CVD or HF. Semaglutide induces significant weight loss due to a decrease in fat mass with preservation of muscle mass.
1494-PUB: Variable Responses to GLP-1 Receptor Agonists
Authors: KUNWAR SANDEEP , SAMSON KAELI , DAVIS CLIFTON , SHIVASWAMY VIJAY , DESOUZA CYRUS
Published: June 2022

Background: GLP1s are ineffective for a subset of patients. Differentiating between responders and non-responders based on baseline variables would allow for an individualized approach to managing diabetes.

Methods: A retrospective analysis of 324 veterans at the Omaha VA with type 2 diabetes on a GLP1 agonist to evaluate effectiveness quantified by reductions in HbA1c (>/= 0.5%) body weight (>/= 3%) and insulin doses (>/= 10% decrease or off insulin) relative to baseline was done with the outcome being a complete response in all three. Associations between categorical variables of interest and the dichotomous outcome were assessed using Chi-Square and t-tests. A logistic regression was run for the dichotomous outcome and included variables with bivariate p-values less than 0.20.

Results: In terms of, response to one, two or all outcome variables, Dulaglutide had, 22 (38.6%) , 21 (36.8%) and 9 (15.8%) ; Liraglutide had 45 (34.6%) , 44 (33%) and 33 (25.3%) ; Semaglutide had 24 (17.5%) , 64 (46.7%) and 43 (31.4%) . Patients on Semaglutide trended towards having higher odds of a complete response (odds 2.45 95% CI 0.93, 6.48) compared to Dulaglutide. Older patients had a higher odds of a complete response (odds 1.95% CI 1.01, 1.p=0.02 Table 1) . Variables including baseline A1c, insulin dose, BMI, Metformin, and eGFR were not significantly associated with a complete response to GLP1.

Conclusion: Age and the type of GLP1 are variables that determine effectiveness.

Disclosure

S.Kunwar: None. K.Samson: None. C.Davis: None. V.Shivaswamy: Research Support; Eli Lilly and Company, Kowa Company, Ltd., Novo Nordisk. C.Desouza: Advisory Panel; AstraZeneca, Bayer AG, Novo Nordisk A/S, Consultant; Asahi Kasei Corporation.
1503-PUB: Modeling the Prediction of Improvement on Gait and Cognition among Patients Receiving Intranasal Insulin
Authors: NGO LONG H. , NOVAK VERA , NOVAK PETER , MANTZOROS CHRISTOS , DAI WEIYING , LIOUTAS VASILEIOS
Published: June 2022

Objective: To model the probability of improvement on gait and cognition among patients who received intranasal insulin (INI)

Methods: 223 patients (1diabetes, 117 controls) randomized into 4 arms: 55 diabetes placebo, 51 diabetes INI, 59 control placebo, 58 control INI, 1women, 66±9 years of age. INI treatment lasted 24 weeks with 40 IU of INI (Novolin® R, off-label use) or placebo (sterile saline) . normal walk speed (NW) , dual task walk speed (DT) , executive function (EF) , verbal memory (VB) . Improvement due was defined to be better performance at end of treatment compared to baseline. Eleven of 20 baseline predictors were selected in a multivariable generalized linear model with logit link and binomial error to predict the probability of improvement among the 1patients who received INI.

Results: 58% of the INI patients improved on NW, 62% improved on DT, 69% EF, and 47% VB. The predictors for the final model included 6 baseline demographic variables (age, number of years of diabetes, number of years in school, Wechsler Adult Reading test, global depression score, and waist circumference; and 5 metabolism-related variables of hemoglobinA1c, fasting plasma glucose, total cholesterol, microalbumin in urine, and microalbumin to creatinine ratio.

Conclusion: Modeling technique also allows us to compute the estimated probability of improvement for any individual patients, thus, enabling us to understand better the particular demographic and metabolic profiles that best predict who among those receiving INI could benefit the most from the treatment. Funded by NIH-NIDDK (1R01DK103902) , FDA (IND#107690) , Novo Nordisk, Inc. (ISS-001063) , Medtronic Inc. (NERP15-0310) and registered on www.clinicaltrials.gov (NCT02415556.)

Disclosure

L.H.Ngo: None. V.Novak: None. P.Novak: Stock/Shareholder; Moderna, Inc., Novavax, Pfizer Inc., Prothena. C.Mantzoros: Advisory Panel; Novo Nordisk. W.Dai: None. V.Lioutas: None.

Funding

Funded by NIH-NIDDK (1R01DK103902) , FDA (IND#107690) , Novo Nordisk, Inc. (ISS-001063) , Medtronic Inc. (NERP15-0310)
1509-PUB: Effects of an Early Postpartum Lifestyle Intervention in Women with Gestational Diabetes Mellitus and Newly Diagnosed Diabetes
Authors: HU GANG , LENG JUNHONG , LIU HUIKUN , WANG LEISHEN , ZHANG SHUANG , LI WEIQIN , LI WEI , YANG XILIN , TUOMILEHTO JAAKKO
Published: June 2022

Very few studies have assessed short-term and long-term cardiovascular effects of an early postpartum lifestyle intervention among women with gestational diabetes mellitus and diabetes. The aim of the present study was to examine whether an early postpartum 9-month intensive lifestyle intervention can lead to weight loss and improve cardiovascular risk factors among women with both GDM and newly diagnosed diabetes, and also to investigate these effects in a long term. A total of 83 women who had GDM and were newly diagnosed as type 2 diabetes at 2.6 year after delivery participated in a 9-month intensive lifestyle intervention and a follow-up survey at 6-9 years post-intervention. A total of 68 women finished the 9-month lifestyle intervention and 39 women finished the 6-9 years post-intervention survey. During the first 9-month intervention, women lost their weight at 2.76 kg (-3.81% initial weight) , decreased their waist circumference (-2.88 cm) , body fat (-1.69%) , diastolic blood pressure (-3.49 mm Hg) , fasting glucose (-0.98 mmol/L) and HbA1c (-0.71%) . During the 6-9 years post intervention, women still lost weight (-3.49 kg; -5.14% initial weight) , decreased their waist circumference (-4.03 cm) , and body fat (-1.93%) , but slightly increased their HbA1c (0.26%) , total cholesterol (0.29 mmol/L) and triglycerides (0.17 mmol/L) . The prevalence of using glucose-lowering agents increased from 2.9% at baseline to 35.3% after the 9 month lifestyle intervention, and to 48.7% at 6-9 years post-intervention. An early postpartum 9-month intensive lifestyle intervention could have effects on weight loss, decreased HbA1c and other cardiovascular risk factors among women with GDM and newly diagnosed diabetes. The weight loss effect with a lifestyle intervention can persist for at least 6 years, however, HbA1c levels slightly increased in the long term.

Disclosure

G.Hu: None. J.Leng: None. H.Liu: None. L.Wang: None. S.Zhang: None. W.Li: None. W.Li: None. X.Yang: None. J.Tuomilehto: Stock/Shareholder; Orion Pharma.

Funding

This study is supported by the grant from European Foundation for the Study of Diabetes (EFSD) /Chinese Diabetes Society (CDS) /Lilly program for Collaborative Research between China and Europe. Dr. Hu was partly supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health.
1513-PUB: HMGB1 Knockdown Increases Glucose Sensitivity, Decreases Hyperglycemia and Insulin Resistance in Type 2 Diabetes
Authors: LIU ZEYU , ALVIDREZ ROBERTO I. MOTA
Published: June 2022

Introduction: Type-2 diabetes (T2D) characterizes by chronic hyperglycemia and insulin resistance. Hyperglycemia causes tissue damage and serious complications. High Mobility Group Box-1 (HMGB1) mediates the onset and progression of T2D, but the exact mechanism of HMGB1 glucose regulation in T2D is poorly understood. Global knockout of HMGB1 is fatal in neonatal mice primarily due to hypoglycemia. Therefore, using an inducible HMGB1 Knockout (iHMGB1 KO) model we evaluated the role of HMGB1 in adult mice progression of T2D (3) . We hypothesize that iHMGB1 KO mice will have decreased longitudinal hyperglycemia with decreased insulin resistance in a Streptozotocin (STZ) induced model of T2D.

Methods: Male 8-week adult iHMGB1 KO mice were injected with Tamoxifen IP for days (1mg/kg) to induce HMGB1 knockdown. HMGB1 Flox (wildtype) were used as control. Then, mice were injected with STZ IP for 5 days (25mg/kg) , diabetic phenotype developed for weeks. HMGB1 knockdown was characterized via immunoblot and RT-PCR. Mice were placed on normal or high fat diet to evaluate T2D progression via metabolic cage analysis (MCA) . Glucose and insulin tolerance tests (GTT and ITT) were performed.

Results: HMGB1 was significantly knocked down in iHMGB1 KO mice. MCA showed that STZ + normal diet had the appropriate respiratory quotient for translational T2D. GTT and ITT demonstrated higher glucose sensitivity and insulin tolerance in iHMGB1 KO T2D mice. Longitudinal glycemia measurement showed that iHMGB1 KO T2D mice have a progressively lower glycemia.

Conclusion: With an effective knockdown of HMGB1, we evidenced increased glucose sensitivity, decreased hyperglycemia and insulin resistance in STZ induced T2D mice. Findings show that decreasing HMGB1 allows T2D adult mice to regulate glucose metabolism and insulin sensitivity better. Further studies will be directed to investigate the mechanisms that govern the role of HMGB1 in T2D.

Disclosure

Z.Liu: None. R.I.Mota alvidrez: None.

Funding

This work was funded by department of surgery support for RIMA
Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1
Authors: Perry Rachel J.
Published: June 2022

With the rising epidemics of obesity and nonalcoholic fatty liver disease (NAFLD) and its downstream consequences including steatohepatitis, cirrhosis, and type 2 diabetes in the U.S. and worldwide, new therapeutic approaches are urgently needed to treat these devastating conditions. Glucagon, known for a century to be a glucose-raising hormone and clearly demonstrated to contribute to fasting and postprandial hyperglycemia in both type 1 and type 2 diabetes, represents an unlikely target to improve health in those with metabolic syndrome. However, recent work from our group and others’ identifies an unexpected role for glucagon as a potential means of treating NAFLD, improving insulin sensitivity, and improving the lipid profile. We propose a unifying, calcium-dependent mechanism for glucagon’s effects both to stimulate hepatic gluconeogenesis and to enhance hepatic mitochondrial oxidation: signaling through the inositol 1,4,5-trisphosphate receptor type 1 (INSP3R1), glucagon activates phospholipase C (PKC)/protein kinase A (PKA) signaling to enhance adipose triglyceride lipase (ATGL)-dependent intrahepatic lipolysis and, in turn, increase cytosolic gluconeogenesis by allosteric activation of pyruvate carboxylase. Simultaneously in the mitochondria, calcium transferred through mitochondria-associated membranes activates several dehydrogenases in the tricarboxylic acid cycle, correlated with an increase in mitochondrial energy expenditure and reduction in ectopic lipid. This model suggests that short-term, cyclic treatment with glucagon or other INSP3R1 antagonists could hold promise as a means to reset lipid homeostasis in patients with NAFLD.
Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial
Authors: Heianza Yoriko , Krohn Knut , Yaskolka Meir Anat , Wang Xuan , Ziesche Stefanie , Ceglarek Uta , Blüher Matthias , Keller Maria , Kovacs Peter , Shai Iris , Qi Lu
Published: June 2022

OBJECTIVE

To investigate whether changes in circulating levels of pancreatic islet–related miRNA-375 (miR-375) are related to improved visceral and intrahepatic fat accumulation.

RESEARCH DESIGN AND METHODS

This study included adults with abdominal obesity from an 18-month weight loss lifestyle intervention trial. Circulating miR-375-3p was measured at baseline and 18 months. MRI was performed (n = 139) to assess 18-month changes in abdominal and intrahepatic fat depots.

RESULTS

Circulating miR-375-3p was related to fasting insulin and insulin resistance in participants with prediabetes. After the interventions, there was a significant increase of miR-375-3p (P < 0.001). Greater increase in miR-375-3p was associated with greater reductions of visceral (P = 0.024) and deep subcutaneous (P < 0.001) adipose tissues and intrahepatic fat content (P = 0.012).

CONCLUSIONS

Increases in circulating miR-375-3p were associated with visceral and intrahepatic fat reduction. Changes in circulating pancreatic islet–related miR-375-3p may be linked to improved diabetogenic fat depots during weight loss lifestyle interventions.
Application of the Argument-Driven Inquiry Learning Model in Stimulating Students' Scientific Argumentation Skills on Acid-Base Material
Authors: Utami Siti Salsabila , Aisyah Ratna Sari Siti , Affifah Isriyanti
Published: June 2022

Literasi sains merupakan kemampuan abad 21 yang perlu dimiliki untuk menghadapi permasalahan yang terjadi di lingkungan sekitar dan menyelesaikannya dengan konsep serta pengetahuan yang telah dimiliki.  Namun masih banyak siswa yang kurang memiliki literasi sains. Rendahnya literasi sains peserta didik mengakibatkan sulitnya peserta didik dalam mengintegritaskan pengetahuan yang didapat dengan empat aspek litersi sains. Tujuan penelitian ini yaitu untuk menganalisis penerapan dan perbedaan hasil belajar sebelum dan sesudah menggunakan model pembelajaran Argument-Driven Inquiry pada materi asam basa. Pada penelitian ini menggunakan desain penelitian pre-eksperimen dengan One-Group Pretest-Postest. Sampel yang digunakan yaitu 30 orang peserta didik kelas XI IPA. Pemilihan sampel menggunakan cara Purposive Sampling. Instrument penelitian yaitu instrument tes pilihan ganda beralasan, lembar observasi dan rencana pelaksanaan pembelajaran. Teknik analisis data yang digunakan uji paired sample t-test. Hasil perhitungan uji paired sample t-test sebesar 0,000 sehingga terdapat perbedaan keterampilan argumentasi ilmiah peserta didik setelah diterapkan model pembelajaran Argument Driven Inquiry (ADI). Peserta didik lebih aktif saat pembelajaran dan memberikan argumentasi ilmiah sesuai dengan komponen argumentasi ilmiah yang baik.
FORMULAÇÃO DE PROBLEMAS DE MATEMÁTICA: ITINERÁRIO DAS PRODUÇÕES ACADÊMICAS BRASILEIRAS NO PERÍODO DE 2011 A 2020
Authors: Teixeira Cristina de Jesus , Eustáquio Moreira Geraldo
Published: June 2022

Este estudo é recorte de uma tese de doutoramento, em andamento, na qual a formulação de problemas nas aulas de matemática constitui objeto de investigação. Este recorte buscou identificar pesquisas nacionais que abordaram, em alguma medida, a formulação de problemas proposta a estudantes dos anos finais do ensino fundamental e médio no período de 2011 a 2020. Especificamente, intentou descrever e analisar elementos que perpassaram o desenvolvimento dessa estratégia. O procedimento adotado foi a revisão sistemática de literatura, pesquisa qualitativa, com recolha de dados nas bases de acomodação da Biblioteca Digital de Teses e Dissertações e no catálogo da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. De forma ampla, os resultados evidenciaram escassez de pesquisas sobre o tema, falta de referencial teórico no cenário brasileiro, justificando a importância de pesquisas que explorem a estratégia formulação de problemas, em particular, no ensino fundamental, etapa em que se observa maior lacuna.
Microzonificación ecoturístico mediante Sistemas de Información Geográfica, distrito de Marco, provincia de Jauja, Junín.
Authors: Acuña Caceres Wendy Michel , Gonzales Gonzales Miqueas , Mendez Gutierrez Raúl
Published: June 2022

La investigación tiene como objetivo diseñar y aplicar el modelo de microzonificación ecoturístico propuesto mediante SIG para el desarrollodel ecoturismo en el distrito de Marco que está ubicado en la parte centraly occidental del Valle de Yanamarca, en la provincia de Jauja. El estudio se realizó desde el año 2019 hasta abril del 2021, la elaboración tuvo tres procesos fundamentales: a) Preparación del proceso llevado a cabo en la ciudad Lima,generando un marco de referencia que guiaría el resto de desarrollo del trabajo; b) Una etapa de campo que involucro viajes, un fuerte componente de consulta con instituciones, poblaciones locales; y c) Una etapa de elaboración del producto final. Como resultado se determinaron zonas bien marcadas: Nivel muy alto de 0.467 de valor, que representa el 10% de uso turístico, depreservar, mantener el ecosistema y los atractivos culturales; nivel alto, de 0.265 valor, que representa el 5% con potencial que puede alcanzar un nivel muy alto. En conclusión, la elaboración de la cartografía, permitió laidentificación de los recursos turísticos, interrelacionar los parámetros y descriptores que permite a la vez ordenar las actividades turísticas. Que posteriormente se diseñó un web mapping “Microzonificación Ecoturísticodel distrito de Marco” que facilitará la difusión del potencial turístico del distrito de Marco, ya que esto permitirá implementar las propuestas y mejorarlas para la satisfacción de los turistas. Además, será una herramientamuy útil en la gestión municipal para el desarrollo de un turismo ordenado y descentralizado.
Actualidad y controversia de la zoonosis como origen del SARS- CoV-2
Authors: Tello Arquíñego Johan Neil , Espejo Sotelo Luis Alejandro
Published: June 2022

Con la presente carta, trataremos de brindar nueva información respecto al origen del SARS-Cov-2, revisandoinformación publicada posteriormente a la del volumen 8 de su revista. La pandemia del Covid 19 producida por el SARSCoV-2 ha producido a la fecha más de 130millones de infectados y 2’700,000 muertos a nivel global provocando colapsosanitario y económico (Cabezas 2020). En el artículo de revisión “Enlaces zoonóticos del coronavirus SARS-CoV-2”, Vol8 N°1 pág 68 (Iannacone et al 2020), se dice que esta enfermedad tiene como antecedentes las epidemias del SíndromeRespiratorio Agudo Severo (SARS) y del Síndrome Respiratorio del Oriente Medio (MERS) y en ambos la fuente del viruso reservorio es el murciélago y sus huéspedes intermediarios son la civeta de la Palmera en el caso del SARS y el camelloen el caso del MERS (Ye et al ., 2020) y en cuanto al SARS- CoV-2 se postula que su reservorio son los murciélagos delgénero Rhinolophus affinis Horsfield (Zhou et al., 2020).
A Comparison of Three Assessment Types on Student Engagement and Content Knowledge in Online Instruction
Authors: Randall Lynda , Jaynes Jessica
Published: June 2022

The research described in this article focuses on determining the effectiveness of Bongo in promoting student retention of concepts in online learning. This study used both quantitative and qualitative measures to examine the effectiveness of student video presentation assignments on student retention of learning and perceptions of the assignment’s contributions to learning. The quantitative methods compared the effects of three treatment conditions (independent reading, Bongo video presentation, and Bongo video presentation with Auto Analysis) on retention of concepts (quizzes administered two weeks after the presentation recordings). Qualitative analysis of student perceptions of the perceived value of Bongo in general, and specifically the Auto Analysis tool, were accomplished through video surveys, transcription, and analysis.  Analysis of the data provided strong support for the use of Bongo to increase student retention of concepts, and also revealed that students held favorable perceptions of the value and utility of the tool.
Online Presentations with PowerPoint Present Live Real-Time Automated Captions and Subtitles: Perceptions of Faculty and Administrators
Authors: Orellana Anymir , Arguello Georgina , Kanzki-Veloso Elda
Published: June 2022

Captioning of recorded videos is beneficial to many and a matter of compliance with accessibility regulations and guidelines. Like recorded captions, real-time captions can also be means to implement the Universal Design for Learning checkpoint to offer text-based alternatives to auditory information. A cost-effective solution to implement the checkpoint for live online presentations is to use speech recognition technologies to generate automated captions. In particular, Microsoft PowerPoint Present Live (MSPL) is an application that can be used to present with real-time automated captions and subtitles in multiple languages, allowing individuals to follow the presentation in their preferred language. The purpose of this study was to identify challenges that participants could encounter when using the MSPL feature of real-time automated captions/subtitles, and to determine what they describe as potential uses, challenges, and benefits of the feature. Participants were full-time faculty and administrators with a faculty appointment in a higher education institution. Data from five native English speakers and five native Spanish speakers were analyzed. Activities of remote usability testing and interviews were conducted to collect data. Overall, participants did not encounter challenges that they could not overcome and described MSPL as an easy-to-use and useful tool to present with captions/subtitles for teaching or training and to reach English and Spanish-speaking audiences. The themes that emerged as potential challenges were training, distraction, and technology. Findings are discussed and further research is recommended.
Effect of labor conditions on quality of life and degree of dysphonia among teachers. hygienic requirements to their prevention
Authors: Dubrovina EA
Published: June 2022

The purpose of our research was to provide a general hygienic assessment of an effect produced by labor conditions on quality of life dependent on the prevalence rate of parameters that form the voice pathology, and to develop prevention recommendations. The interrelation between objective complaints and diagnosed voice pathologies was examined. 224 teachers aged ≥ 38 y. o. who participated in the study were selected based on subjective complaints and objective data. Two examined groups of teachers were formed during the preliminary survey. The first control group consisted of 30 healthy non-smoking men and 70 women. The second group included 26 men and 98 women with different voice disorders. 79% of those surveyed had voice disorders (dysphonia), and 28% had aphonia, which occurred in those surveyed 2–5 times during the academic year. Over 70% of teachers from the second group lost their voice strength, 61% complained of periodically occurring hoarse and husky voice, one third (32%) had dry cough, every fourth person (24%) complained of decreased voice pitch. The extraordinary majority of teachers (77%) associated their voice distortion with a great professional vocal load. Remote results obtained at six months after the therapeutic and preventive course of Homeovox in teachers of higher educational institutions with a voice pathology significantly confirmed life quality improvement.
OPTIMALISASI APLIKASI SIBELIUS 7 DALAM PEMBELAJARAN SENI MULTI BUDAYA BERBASIS LEARNING OUTCOMES
Authors: Aulia Sri Mustika , Afriadi Putra , Virganta Anada Leo , Purnomo Try Wahyu
Published: June 2022

Penelitian ini merupakan penelitian pengembangan yang menghasilkan bahan ajar terintegrasi dengan aplikasi Sibelius 7 sebagai upaya optimalisasi pembelajaran seni multi budaya (musik) berbasis learning outcomes. Penggunaan aplikasi tersebut tentunya menjadi salah satu alternatif pemenuhan kompetensi seni siswa sebagai calon guru. Konteks mahasiswa yang berasal dari keragaman budaya menjadi dasar pemikiran bagi peneliti untuk membuat bahan ajar yang dapat mencakup berbagai seni dan budaya yang ada di Indonesia. Produk yang dihasilkan telah melalui tahapan pengujian validitas, implementasi, dan efektivitas. Dengan pengujian yang dilakukan, E-Module yang dihasilkan valid (layak secara isi dan tampilan), implementatif (mudah digunakan oleh dosen dan mahasiswa), dan efektif (dapat meningkatkan proses dan hasil belajar mahasiswa). Model pengembangan yang digunakan adalah model 4D yang menekankan perlunya hasil belajar. Pada tahap define dilakukan analisis kebutuhan, analisis konsep, analisis prestasi belajar mata kuliah, analisis penggunaan, dan analisis keanekaragaman budaya. Tahap pengembangan dilakukan dengan 3 kegiatan utama, yaitu: uji validitas, uji implementasi, dan uji efektivitas. Kemudian, pada tahap akhir, produk disebarluaskan dalam skala yang lebih luas
PENGEMBANGAN E-BOOK BERBASIS BUDAYA LOKAL SUMUT PADA MATA KULIAH PENDIDIKAN IPS KELAS TINGGI PGSD UNIMED
Authors: Nasution Yusra , Tambunan Husna P. , Risma Risma
Published: June 2022

Penelitian ini bertujuan untuk: (1) mendeskripsikan hasil uji ahli mengenai produk E-Book Berbasis Budaya Lokal Sumut Pada Mata Kuliah Pendidikan IPS Kelas Tinggi PGSD Unimed, dan (2)  mendeskripsikan keterpakaian pengembangan E-Book Berbasis Budaya Lokal Sumut Pada Mata Kuliah Pendidikan IPS Kelas Tinggi PGSD Unimed. Metode penelitian yang digunakan adalah model penelitian dan pengembangan (Research and Development/R&D) dengan model pengembangan Van den Akker dengan mengembangkan e-book Pendidikan IPS Kelas Tinggi Berbasis Budaya Lokal Sumut.  Lokasi pelaksanaan penelitian dilakukan di prodi PGSD FIP Unimed yang terletak di Jl. Willem Iskandar / Pasar V, Medan. Populasi penelitian ini adalah seluruh mahasiswa PGSD Unimed stambuk 2020 berjumlah 225 mahasiswa yang terdiri dari 11 (A-K) kelas reguler dan ekstensi. Sampel penelitian ini dilakukan secara acara kelas dan terpilihlah satu kelas yakni kelas B Reguler 2020 yang berjumlah 40 mahasiswa. Hasil penelitian menunjukkan bahwa E-Book Berbasis Budaya Lokal Sumut Pada Mata Kuliah Pendidikan IPS Kelas Tinggi PGSD yang dikembangkan telah divalidasi oleh ahli materi dan media. Diperoleh rata-rata skor dari ahli materi tahap I yakni 71% dengan kriteria “Layak” dan rata-rata skor ahli materi tahap II adalah 90,6 % dengan kriteria “Sangat layak”. Dan hasil penilaian ahli media 91,43% dengan kriteria “Sangat layak”. Pada uji coba produk  E-book kepada mahasiswa diperoleh  uji coba pre-tes dengan ketuntasan 23,07% dan hasil post-tes dengan  ketuntasan 96,15%.  Maka disimpulkan bahwa produk E-Book Berbasis Budaya Lokal Sumut Pada Mata Kuliah Pendidikan IPS Kelas Tinggi PGSD Unimed layak, efektif, dan praktis digunakan untuk mahasiswa PGSD Unimed stambuk 2020
ANALISIS STRATEGI CITRA MEREK DALAM MENINGKATKAN KEPUASAN PELANGGAN OCTO MOBILE
Authors: Oktaviani Oktaviani , Zulkifli Zulkifli , Supriadi Edi
Published: June 2022

The purpose of this study was to determine the effect of promotion, service quality, and innovation directly or indirectly on Brand Image, as well as the effect of all these variables on OCTO Mobile customer satisfaction. The research sample was 385 respondents who were CIMB Niaga customers. The sampling technique was purposive sampling—data collection using a questionnaire and FGD. The data analysis technique used Structural Equation Modeling (SEM) analysis which aided with SmartPLS software. The study results prove that the variables of service quality and innovation have a significant effect on brand image and brand image has no significant effect on customer satisfaction. However, the promotion variable does not have a significant effect on brand image. Promotion variables, service quality, and innovation significantly affect customer satisfaction, while the brand image variable has no significant effect on customer satisfaction. The results also show the customer satisfaction strategy plan by referring to the strategies from the analysis that has been done, and the right strategy is selected, namely product development.
O MASP online: as estratégias educacionais do museu na pandemia
Authors: Canto Aylana , da Silva Delfino Duarte Ana Helena
Published: June 2022

Este artigo tem como objetivo compartilhar a atual pesquisa de mestrado vinculada ao Programa de Pós-Graduação em Museologia da Universidade Federal da Bahia (PPGMuseu / UFBA) orientada pela Doutora Ana Helena da S. Duarte. Em nossa pesquisa investigamos a ação de mediação cultural proposta e realizada pelo Museu de Arte de São Paulo - MASP durante a pandemia COVID-19. Nas redes sociais, em especial no Instagram, este Museu intercambiou e instigou seu público a aprender, interagir e produzir com objetos de arte de seu acervo. Através de estratégias educacionais, consideramos a Abordagem Triangular e o Museu Educacional Online como alicerce deste seu percurso. A investigação persegue e explora as estratégias educacionais elaboradas e realizadas pelo MASP para o seu público no espaço virtual, ou seja, na modalidade online. As teorias que referenciam nossa base estão alicerçadas a partir de três eixos fundamentais: a Teoria Educacional de Paulo Freire (educador e filósofo brasileiro), e sua influência no Museu da Educação Brasileira; a Abordagem Triangular, proposta por Ana Mae Barbosa (educadora, pioneira na arte-educação); e a Teoria Semiótica greimasiana (no estudo da relação entre planos de texto circunscritos através das línguas, proposta Algirdas Julien Greimas, e que possibilitou, no escopo desta pesquisa, a investigação dos textos). Combinados, estes eixos trazem à tona a análise da produção de sentido do público do MASP, por meio da Mediação Cultural em constante diálogo com o conceito de Museu Educacional Online (OEM) - proposto por Frieda Marti (Doutora em Educação pela Universidade do Estado do Rio de Janeiro - PROPED / UERJ). O procedimento metodológico da pesquisa é baseado na abordagem teórica e bibliográfica (instrumentalização teórica dos conceitos para a pesquisa) e na investigação analítica em um estudo de caso (a análise dos discursos da Mediação Cultural Online do MASP durante a pandemia). Como objetivo geral, busca-se estabelecer uma relação entre as ações educativas e as estratégias metodológicas em Mediação Cultural Online desenvolvidas pelo MASP, mediadas pela análise da produção feita para o público neste processo, assumido a ação no virtual como contribuição para o Museu da Educação Brasileira no contexto da pandemia e isolamento social – durante o período de março de 2020 a agosto de 2021. Para tanto, nosso problema de pesquisa é pensar o Museu da Educação na pandemia. Nosso caminho é, portanto, no sentido de refletir e criar um ambiente saudável para debater o Museu da Educação no contexto de pandemia e isolamento social no Brasil.
El diseño a través de las pantallas: Las adaptaciones del diseño de interiores elaboradas para redes sociales
Authors: Catrópa da Silva Andréa , Covre Sagrillo Isabela
Published: June 2022

En la pandemia de Covid-19, el mundo virtual se ha vuelto aún más popular entre las personas y las empresas, con la intención de mantener las conexiones que fueron inhibidas por el distanciamiento social. En este escenario, el comercio virtual y los influencers digitales invirtieron aún más en lo que se conoce en el ámbito de la arquitectura comercial y el diseño como “Instagrameable”. Ambientes, alimentos, ropa, objetos, todo ha necesitado llamar la atención en las redes sociales y, para eso, la gente apela a funcionalidades “Instagrameables”, es decir, algo que sea fotográficamente interesante, que incite al deseo, la empatía y el sueño. Sin embargo, este tema es aún poco estudiado en la academia, ya que la articulación de elementos y espacios destinados a la difusión de las redes sociales aún no tiene un desarrollo teórico sólido, por ser un tema reciente. A partir de una observación práctica de espacios que tienen esta denominación como principal característica, este trabajo comienza a elaborar un concepto académicamente aceptable para esta tendencia que probablemente se instale en el mercado debido al constante auge de los medios digitales en la sociedad. Si observamos un entorno físico hecho para fines residenciales, comerciales u otras necesidades diarias, encontraremos en el uso de características de confort térmico y acústico, ergonomía, iluminación y funcionalidad. Sin embargo, cuando etiquetamos un entorno “Instagrameable” o cuando analizamos escenarios preparados y dedicados a la fotografía en medios sociales, identificamos otras características, más adecuadas a la propagación de la imagen digital y a la visualización bidimensional de dichos espacios. Existe, por tanto, un cierto estándar de aspecto estético que siguen los espacios dirigidos mayoritariamente a la creación de contenidos para medios sociales, como los “espacios Instagrameables” o los museos selfie (lugares hechos con escenarios adecuados para tomar autorretratos), como medio para atraer a la gente a visitarlos y a tomar fotos para ser compartidas en las redes sociales. Pero, ¿qué es lo que hace que un lugar sea atractivo para ser expuesto en internet? ¿Qué características llevan a la gente a fotografiar determinados lugares? Este artículo identifica las características de diseño de interiores comunes a este tipo de ambiente, centrándose en los museos selfie que se encuentran en todo el mundo. Para ello, se realiza una recopilación de museos selfie utilizando principalmente su principal vertical de comunicación, Instagram, para poder establecer una taxonomía de lo que se considera “Instagrameable” para los ambientes comerciales, y posteriormente, tras esta investigación práctica, con un mayor desarrollo teórico, establecer conceptos y directrices de lo que es un espacio “Instagrameable” para el ámbito académico.
Cubiertas de trabajo duro
Authors: Hajian George
Published: June 2022

“...Un buen informe arqueológico no solo menciona acerca de los estratos de los que se originan los hallazgos, sino que también da cuenta de los estratos que tuvieron que romperse primero “ (Benjamín, 2005). Trabajo con materiales analógicos impresos. Como parte de mi práctica artística, rompo, corto, rasgo, doblo y pego imágenes de la actuación masculina y el cuerpo masculino para deshacerlo y revelar su fragilidad. Durante el proceso de creación, lo que generalmente se deja atrás es un revoltijo de desechos no representativos, principalmente texto, fondos y dispositivos utilizados en una página de una revista o un libro. Durante la primera cuarentena por COVID en Nueva Zelanda en 2020, tuve acceso limitado a nuevo material de collage, aparte de algunos libros que quedaron en mi automóvil. Como resultado, mi atención se centró en las sobras que, de otro modo, terminarían en la papelera de reciclaje. Estos fragmentos descartados ilustraban un lenguaje de género, porque el material que usé estaba destinado a un público masculino. Respaldaba los músculos, el tamaño, la competencia, la violencia y cualquier otra cosa que pudiera esperar de la ficción, la publicidad y las páginas reveladoras que promueven la llamada “masculinidad”, como anuarios de cine, revistas de musculación, deportes y revistas impresas para adultos, entre otras. Algunos de estos libros fueron donados y muchos otros recuperados de oportunidades y tiendas de reciclaje, ya que fueron retirados de bibliotecas personales, públicas y universitarias. Casi todas las portadas de los libros utilizadas en el proyecto tenían sus propias historias impresas en ambos lados. Estas “marcas” revelaban sus orígenes, relataban sus vidas y transmitían la tensión que tuvieron que soportar los innumerables lectores, y por supuesto yo mismo. Al incorporar palabras impresas en un discurso visual, estos nuevos collages exigen una reconsideración del texto y el significado: insinúan, pero al mismo tiempo complican el proceso de decodificación textual. Procedente de los desechos de una cultura impresa, estas obras intentan reconstruir la cultura material y visual, una cultura consumida por la búsqueda de atención y poder. Se centran en su propia materialidad y, al mismo tiempo, intentan romper con el orden y revelar su significado incrustado. Reconfiguran el significado para contar y volver a presentarse a sí mismos. Resucitados, estos trabajos ensamblados están ansiosos por volver al estante de la biblioteca y volver a entrar en circulación en un nuevo formato. “Hard Working Covers” es un proyecto en curso que reúne 90 collages analógicos únicos hechos a mano en portadas de libros de tapa dura y los compila en 300 libros de concertina de edición limitada. El formato desplegable de la publicación revelará no solo el frente de las obras, sino también su reverso.
Guerrilleros contra Franco: un conflicto mediado por la propaganda
Authors: Recio García Armando
Published: June 2022

El uso de la propaganda ha sido consustancial a los conflictos armados y en el caso del movimiento guerrillero español de los años 40 también lo fue. La resistencia armada frente a la dictadura de Franco comprendió desde sus inicios que la propaganda debía ser un elemento de acompañamiento fundamental en sus acciones contra el régimen. A través de un variado repertorio de actividades propagandísticas que incluían la edición y difusión de pequeñas publicaciones periódicas, la confección de octavillas y hojas sueltas, la realización de pintadas en fechas conmemorativas o los mítines tras la toma momentánea de alguna localidad, la propaganda fue un fenómeno presente en todo momento en la actividad del maquis.
Por otro lado, el régimen franquista también utilizó la propaganda de forma sistemática en su lucha contra las partidas guerrilleras. No solo silenció sus actividades en la prensa, utilizando la censura como herramienta habitual, sino que también supo emplear el terror y la represión como instrumentos de persuasión dirigidos contra los miembros de las guerrillas, pero también contra la población susceptible de prestarles apoyo. La criminalización y el intento de despojar de cualquier sentido político a la lucha guerrillera fueron algunas de sus armas en este campo.