bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of MUET Results Based on K-Nearest Neighbour Algorithm
Authors: Sabri Norlina Mohd , Hamrizan Siti Fatimah Azzahra
Published: October 2023

The machine learning based prediction has been applied in various fields to solve different kind of problems. In education, the research on the predictions of examination results is gaining more attentions among the researchers. The adaptation of machine learning for the prediction of students’ achievement enables the educational institutions to identify the high failure rate, learning problems, and reasons for low student performance. This research is proposing the prediction of the Malaysian University English Test (MUET) results based on the K-Nearest Neighbour Algorithm (KNN). KNN is a powerful algorithm that has been applied in various prediction problems. The prediction of the MUET results would help the students and lecturers to be more well prepared and could improve the required English language skills accordingly before the actual examination. The MUET result prediction is based on the student’s English courses grades and there are 516 data of students’ results that have been collected from Universiti Teknologi MARA (UiTM) Dungun campus. The performance measurement that has been used are the mean accuracy, percentage error and mean squared error (MSE). In this research, the KNN prediction model has generated an acceptable performance with 65.29% accuracy. For future work, KNN could be modified or hybridized to further improve its performance. Furthermore, other algorithms could also be explored into this problem to further validate the best predictive model for the prediction of the MUET results.
Pelatihan Digital Marketing Pada UMKM Binaan Kadin Sukabumi
Authors: Ginanjar Heri , Berliana Berliana , Rachmadio R. Edy
Published: October 2023

Pemberdayaan UMKM merupakan usaha yang tampil sebagai salah satu kelompok usaha yang dapat dijadikan penentu atau andalan dalam mengelola tata kota usaha daerah. Kegiatan pengabdian ini dilaksanakan kepada UMKM binaan Kota Sukabumi melalui  metode ceramah, tutorial, dan diskusi. Target materi pada kegiatan penyuluhan PKM  tercapai dengan cukup baik, dapat dilihat dari hasil pemahaman dari materi kegiatan. Untuk menerapkan hasil dari kegiatan masih diperlukan UMKM binaan dapat melaksanakan dan mengimplementasikan digital marketing pada setiap usahanya dengan memaksimalkan fasilitas yang ada
Bimbingan Teknik Penyusunan Laporan Keuangan BUMDesa Rahardja Di Desa Rancaekek Wetan Kecamatan Rancaekek Kabupaten Bandung
Authors: Sa'adah Sa'adah , Arwaty Dini , Sukmawati Fitri , Shaleh Khaerul , Mulyawan R. Ferry , Nababan Daniel
Published: October 2023

Kegiatan perekonomian di desa Rancaekek Wetan, disemangati dengan aktifnya kembali BUM Desa Rahardja. Sebagian dari anggota masyarakat desa yang terpilih untuk mengelolanya, memerlukan keterampilan yang mumpuni. Salah satu keterampilan yang dituntut adalah pengelolaan pencatatan kegiatan BUMDes secara profesional. Kegiatan Pengabdian Kepada Masyarakat (PkM) di BUM Desa Rahardja, Desa Rancaekek Wetan, Kecamatan Rancaekek, Kabupaten Bandung, Propinsi Jawa Barat bertujuan untuk membantu bagaimana cara menyusun laporan keuangan BUMDesa Rahardja dalam rangka peningkatan kualitas kinerjanya. Salah satu amanat Pemerintah mengenai Desa adalah meningkatkan kesejahteraan masyarakat desa, yang diterapkan melalui pendirian Badan Usaha Milik Desa (BUMDes), yang berkewajiban untuk menyusun laporan keuangan. Hasil observasi dan wawancara bersama Tim-PKM dan mitra di lapangan, BUM Desa Rahardja memiliki permasalahan pada bidang manajemen. Khususnya pada aspek pengelolaan pencatatan semua kegiatan BUM Desa, yaitu akuntansi. Solusi untuk pelaksanaan kegiatan PkM tahap ini untuk mengatasi masalah penyusunan laporan keuangan yang dikembangkan dapat berjalan dengan sukses. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan ketrampilan teknis para pengelola BUMDes dalam menyusun laporan keuangan yang sesuai dengan Standar akuntansi Keuangan Entitas Kecil, Mikro dan Menengah (SAK-EMKM). Kegiatan pengabdian kepada masyarakat ini memberikan materi bimbingan teknis yang meliputi sistem akuntansi, persamaan dasar akuntansi, jurnal umum, buku besar, buku pembantu serta laporan keuangan. Hasil dari kegiatan ini adalah peningkatan pemahaman para peserta mengenai konsep dasar akuntansi, penggunaan kode akun.
Kewirausahaan Dan Laporan Tanggung Jawab BUMDes/UMKM Kabupaten Ciwidey, Cicalengka, Lembang
Authors: Yusuf Paulus Sugianto , Susiani Rini , Hardika Andhika Ligar , Syafdinal Syafdinal , Ilyas Supriyanto
Published: October 2023

Universitas Widyatama bekerja sama dengan kepala Gerakan Nusantara Hijau pada Kecamatan Cicalengka, Ciwidey dan Lembang untuk memberikan pelatihan dan pendampingan kepada para pendamping yang tersebar di seluruh Kecamatan Cicalengka, Ciwidey dan Lembang untuk mendapatkan bekal pengetahuan dan keterampilan sehingga dalam memberikan pengarahan dan pendampingan pada UMKM di bawah pengawasannya dapat memberikan saran yang tepat dan dapat membantu memecahkan masalah yang dihadapi para pelaku bisnis, yang pada umumnya berpendidikan rendah dan tidak mempunyai keahlian yang memadai
Creating Village Website as a Supporting Medium for Promoting Tourism and Disseminating Information
Authors: Hendar Hendar , Sujatna Meita Lukitawati , Zuraida Ida , Heryono Heri , Aryanti Maya Lisa
Published: October 2023

Pengabdian kepada masyarakat (PkM) merupakan salah satu tanggung jawab dosen untuk berkontribusi kepada masyarakat sekitar. PkM bersifat teknis sebagai upaya untuk melaksanakan salah satu dharma Perguruan Tinggi. Oleh karena itu, penelitian dan pengabdian kepada masyarakat adalah kegiatan yang bersifat wajib yang harus dilaksanakan oleh seluruh dosen, termasuk dosen Bahasa Inggris khususnya di Fakultas Ilmu Budaya, Universitas Widyatama Bandung. Program Studi Bahasa Inggris di Universitas Widyatama Bandung telah mendorong para guru dan siswa untuk mendukung desa dalam membangun dan menyediakan konten web sebagai aplikasi keterampilan menulis. Mitra program pada pengabdian masyarakat ini adalah warga Desa Karyawangi. Masalah utama mitra kami adalah kurangnya keterampilan menulis, serta kurangnya pemahaman dan penggunaan media digital sebagai sarana promosi dan penyebaran informasi. Kegiatan ini bertujuan untuk memfasilitasi pembuatan website desa sebagai media pendukung peningkatan efektifitas penyebaran informasi dan promosi atraksi wisata Desa Karyawangi. Penelitian ini dirancang sebagai penelitian deskriptif-korelasional dengan metode survei. Metode yang digunakan dalam penelitian ini adalah pendekatan deskriptif kualitatif dimana lokasi penelitian dilakukan di Desa Karyawangi Kecamatan Parongpong Kabupaten Bandung Barat. Pengumpulan data dilakukan dengan menggunakan kuesioner online (e-questionnaire), wawancara, dan data sekunder. Pelaksanaan kegiatan pengabdian masyarakat ini telah berhasil mengenali karakter pengguna website, termasuk kualitas, dan efektivitas website untuk menyebarkan informasi. Hasil penelitian menunjukkan bahwa 1) Pentingnya memiliki website desa, 2) kesadaran untuk mencari informasi dari website masih perlu lebih digalakkan. Dan 3) Website masih membutuhkan pengembangan, sehingga lebih banyak fitur yang ditambahkan untuk mengakomodasi kebutuhan pengguna.
Insentif Pajak Sebagai Strategi UMKM Binaan Dalam Menghadapi Dampak Covid-19 Di Kota Bandung
Authors: Hermawan Wawan , Firman Muhammad , Joko Joko
Published: October 2023

Kegiatan pengabdian kepada masyarakat ini bertujuan memberikan  pemahaman mengenai kebijakan pemerintah mengenai pemberian insentif pajak; pemahaman atas masa pembayaran,  penyetoran dan pelaporan pajak; dan perhitungan atas pph (pajak penghasilan).  kegiatan pengabdian ini dilaksanakan kepada masyarakat melalui  metode ceramah, tutorial, dan diskusi. Target materi pada kegiatan penyuluhan PKM  tercapai dengan cukup baik, dapat dilihat dari hasil pemahaman dari materi kegiatan. Untuk menerapkan hasil dari kegiatan masih diperlukan UMKM binaan di sektor kuliner dan fashion dapat  melaksanakan pengadministrasian keuangan yang baik, merencanakan strategi keuangan yang baik dan perencanaan perpajakan tepat guna dan tertib administrasi.
Efektifitas Media Animasi Dan Video Presentasi Terhadap Tingkat Kognitif Dan Tingkat Konsentrasi
Authors: Wijaksono Guntur Dwi , Grahita Banung
Published: October 2023

Pembelajaran online telah menjadi tren yang semakin populer dalam beberapa tahun terakhir. Sebagai hasilnya, popularitas startup pendidikan berbasis teknologi atau edutech startup meningkat di Indonesia. Ruangguru menempati peringkat pertama strartup edukasi terpopuler dengan persentase sebesar 98%, disusul Zenius 76%, Arkademi 31%, Pahamify 29%, Cakap 28%. Menurut survey yang dilakukan oleh Ruangguru, 92% anak terbukti lebih cepat paham materi pelajaran dengan video animasi Dafa dan Lulu. Penelitian ini mengungkap sejauh mana keefektifan animasi Dafa dan Lulu terhadap tingkat kognitif dan konsentrasi siswa dibandingkan dengan video presentasi konfensional. Penelitian ini menggunakan metode campuran (mixed method), penelitian kuantitatif menggunakan pendekatan quasi experiment, dimana penelitian ini akan menganalisis perbandingan tingkat kognitif dan tingkat konsentrasi pada kelompok animasi dan kelompok video presentasi.  Hasil dari penelitian ini adalah Penggunaan media pembelajaran video Animasi Ruangguru Dafa dan Lulu tidak lebih efektif dibandingkan media pembelajaran video presentasi konfensional dalam meningkatkan pemahaman peserta didik kelas 4 SD dengan selisih skor 2,26%. Penggunaan media pembelajaran video Animasi Ruangguru Dafa dan Lulu lebih efektif dibandingkan media pembelajaran video presentasi konfensional dalam menjaga tingkat konsentrasi belajar peserta didik kelas 4 SD dengan selisih skor 3,75%.
Implementasi Artificial Intelligence Dalam Iklan Politik Menuju Masyarakat Indonesia 5.0
Authors: Mirza Isroni Muhammad Miraj
Published: October 2023

Artificial Intelligence merupakan teknologi baru yang digunakan untuk membantu menyelesaikan berbagai kebutuhan manusia dalam banyak aspek kehidupan manusia. Salah satu aspek tersebut ialah berkaitan dengan politik. Dalam hal ini, Artificial Intelligence (AI) sudah mulai coba diimplementasikan misalnya dalam hal kampanye politik, tidak terkecuali Indonesia. Secara lebih spesifik isu yang muncul dalam hal penerapan AI di bidang politik ialah berkaitan dengan efektifitas, resiko, serta tantangan yang harus dihadapi oleh perkembangan teknologi baru ini dalam membantu mengubah warna iklan politik yang jauh lebih baik ke depannya. Perkembangan dan penggunaan AI yang semakin masif serta canggih ke depannya ialah tanda menuju masyarakat 5.0.  Hasil dari tulisan ini menyatakan bahwa penerapan teknologi Artificial Intelligence (AI) dalam political marketing berupa iklan politik memiliki sejumlah resiko namun juga manfaat bagi perkembangan media iklan politik ke depannya yang mana hal tersebut memerlukan sosialisasi dan kerjasama baik dari pihak masyarakat maupun pemerintah agar penggunaan AI dalam ranah politik bisa dioptimalisasikan dengan baik dan benar, termasuk di Indonesia. Sehingga hal ini bisa mentransformasikan tatanan sosial politik masyarakat Indonesia ke arah yang lebih baik, kondusif dan canggih sesuai konsep masyarakat 5.0.
Aplicación de un recubrimiento de almidón de maíz en masa de pizza precocida
Authors: Muchiutti Gabriela Silvina , Barrios Ludmila Genraldine , Cámera Nancy Genoveva , Pancrazio Gastón Ignacio , Larrosa Virginia Judit
Published: October 2023

Este estudio evaluó el efecto de un recubrimiento de almidón de maíz con aceite esencial de orégano en masa de pizza precocida (MPP) durante un almacenamiento. Se experimentó la técnica de inmersión, mediante diseño bifactorial (30-60 segundos de inmersión y 60-120 minutos de secado). Se analizó la influencia sobre peso, volumen, color, firmeza y humedad, se seleccionó el mejor proceso, siendo este de 60 segundos de inmersión y 120 minutos de secado. Se estudiaron cuatro condiciones de envasado, muestras recubiertas y no recubiertas, colocadas o no en bolsas de polipropileno, durante un almacenamiento de siete días a 25°C. Las masas recubiertas tuvieron valores mayores de a*, L* y humedad que la muestra sin recubrir. La MPP recubierta consiguió mantener peso, contenido de humedad superior al 20%, y una firmeza  constante, siendo inferior a la de las otras muestras. El parámetro L* fue superior a 64 en todas las condiciones estudiadas. El análisis sensorial concluyó que el PPD recubierto tuvo excelente aceptación de los consumidores evaluados. Se concluye que los recubrimientos ofrecen una posibilidad de uso en la industria panadera.
La participación criminal en el femicidio: autoría y complicidad sujetas a condicionantes específicas del tipo penal
Authors: Tayo Cajamarca Jennifer Estefania , Sichiqui Zarate Ana Belén , Monsalve Robalino Bernardo Xavier
Published: October 2023

Introducción: al ser el femicidio un delito doctrinalmente clasificado como especial, se encuentra constituido por condicionantes específicas, las cuales, necesariamente se deben cumplir por el autor del delito al momento de la consumación de este. No obstante, al existir la participación de varios sujetos activos en el hecho ilícito, en el instante de verificar las actuaciones para la determinación de la autoría o complicidad, ocurre la falta de configuración de condicionantes específicas y con ello la confusión para determinar el tipo penal adecuado. Objetivo: en este contexto, en el presente artículo se realizó una análisis doctrinario y legal del tipo penal de femicidio y la participación criminal, con el objetivo de determinar que grados de participación existen en el femicidio y en consecuencia que conductas son susceptibles de una apreciación distinta. Metodología: la investigación se llevó a cabo a través de un enfoque cualitativo, de la mano con métodos de investigación jurídico-histórico, jurídico-descriptivo y jurídico-propositivo. Resultados: los resultados demostraron que conforme la redacción del Código Orgánico Integral Penal respecto de la participación, en armonía con la teoría del dominio del hecho, existen en el femicidio todos los grados de participación a excepción del referido en el artículo 42 numeral 2 literal d. Conclusión: se pudo concluir que el elemento determinante para la solución de problemas de participación en el femicidio es el estudio de los elementos subjetivos y objetivos que configuran la mencionada teoría. Área de estudio general: Derecho. Área de estudio específico: Penal.
Sarcopenia en pacientes adultos post COVID-19
Authors: Apolo Mena Luis Alberto , Espinoza Reibán Esteban Adrián
Published: October 2023

Introducción: La pandemia por Covid-19, a nivel mundial, tuvo repercusión en diferentes aspectos de la salud de los pacientes afectados, a más del compromiso respiratorio, se evidenció que a mayor parte presento compromiso nutricional como la sarcopenia que se define como la presencia de pérdida de masa y función musculares. Objetivo: Fundamentar la sarcopenia en pacientes adultos post covid-19. Metodología: Se realizó una revisión bibliográfica tipo narrativa, para lo cual se escogieron artículos seleccionados desde páginas oficiales de la Universidad Católica de Cuenca, en bases científicas como: Pubmed, Scopus y la Biblioteca Virtual en Salud. Resultados: La falta de capacidad resolutiva de los centros médicos ante la pandemia por COVID-19, dejo de un lado la evaluación nutricional de los pacientes hospitalizados, aumentando el riesgo de sarcopenia, patología que aumenta la morbimortalidad y estancia hospitalaria. Área de estudio general: Medicina. Área de estudio específica: Microbiología. Tipo de estudio: Revisión bibliográfica.
Menelisik Praktik Pengelolaan Dana Desa Melalui Sebuah Pemaknaan Kepala Desa
Authors: Sulaiha Wati  , Faisol
Published: October 2023

This research aims to determine the phenomenon of village fund management practices from planning, implementation of administration, and accountability through the meaning of awareness from the village head. The research uses a qualitative phenomenological approach to collecting data through observation, interviews, and documentation. The results of this research found that the Musrenbangdes in Mor Songai Village regarding the approval of village fund planning and budgeting only involved 3 BPD representatives. There is no transparency in the management of village funds in Mor Songai Village because the village fund management process is still in the learning stage. The implementation of administration in Mor Songai village did not run properly because administration was not carried out by the village treasurer. There is no accountability of the village head to the community due to weak BPD oversight of the village head's performance. The supervision and supervision carried out by the community in managing village funds did not work well because there was intimidation from the village head towards the community.
Analisis Pengaruh Gaya Kepemimpinan, Teamwork Dan Kompensasi Dalam Meningkatkan Efektifitas Kinerja Karyawan Perusahaan Air Minum (PDAM) Kabupaten Ngawi
Authors: Indartini Mintarti , Rohmatiah Ahadiati , Darmoko Henry Windrianto
Published: October 2023

Related to its very strategic role, the Municipal Waterworks of Ngawi District is required to have the company's performance in meeting the needs of drinking water in the community. One of them is the presence of good employee performance. This study aims to determine the partially and simultaneously influence of leadership style, teamwork and financial compensation on employee performance at the Municipal Waterworks of Ngawi District. The research population is all employees of the Municipal Waterworks of Ngawi District in 2022, totaling 288 people. The sample size was determined using the Slovin formula so that a sample of 74 employees was obtained which was determined by simple random sampling technique. The data analysis technique used the classical assumption test, multiple linear regression analysis, the coefficient of determination analysis, and hypothesis testing using the t test and F test. The results of the study are: 1) Leadership style, teamwork and financial compensation partially influences to the employee performance at the Municipal Waterworks of Ngawi District, 2) Leadership style, teamwork and financial compensation simultaneously influences to the employee performance at the Municipal Waterworks of Ngawi District.
Response to the letter to the editor regarding The Impact of Prenatal Exposure to Chernobyl Fallout in Finland
Authors: Sipiläinen Matti
Published: October 2023

The response letter addresses concerns by Auvinen and Siiskonen about the study on "Prenatal Exposure to Chernobyl Fallout in Finland." It highlights statisticly significant impacts despite low radiation doses, referencing similar research.
Letter to the editor regarding The Impact of Prenatal Exposure to Chernobyl Fallout in Finland
Authors: Auvinen Anssi , Siskonen Teemu
Published: October 2023

Letter to the editor regarding The Impact of Prenatal Exposure to Chernobyl Fallout in Finland
ANÁLISE DOS NÍVEIS DE ESTRESSE ASSOCIADOS AO USO DO TELEFONE CELULAR PARA RELAÇÕES DE TRABALHO
Authors: Bragagnolo Sandra Mara , Alves Bremn Nadielly
Published: October 2023

O trabalho é espaço de desenvolvimento humano, em que as pessoas descobrem suas habilidades e potencialidades, entretanto, nesse ambiente, são submetidas a desgastes e sintomas associados ao estresse, os quais podem prejudicar sua saúde. Diante dessa problemática, essa pesquisa quantitativa e descritiva, mediante a aplicação de questionário, analisa como o uso do telefone celular para fins de trabalho impacta nos níveis de estresse dos trabalhadores. Chegou-se à conclusão de que 46,31% manifesta sinais de estresse. Sobre as percepções a respeito da utilização do telefone celular para fins de trabalho, identificou-se que 44,4% dos respondentes não estão satisfeitos com o uso de seus números e aparelhos pessoais para fins de trabalho, pois pensam que a empresa deveria disponibilizar números corporativos, orientando para que os funcionários só venham a utilizar dentro dos horários de expediente. As percepções dos respondentes convergem todas para a ideia de que o uso do telefone celular para fins de trabalho precisa passar por ajuste, pois, pelo que mostram os dados dessa pesquisa, contribui para o aumento do estresse.
Palavras-Chave: Estresse. Uso do Telefone Celular.
 
Abstract: Work is a space for human development, where people discover their abilities and potential, however, in this environment, they are subjected to stress-related wear and symptoms, which can harm their health. In light of this issue, this quantitative and descriptive research, through the administration of a questionnaire, analyzes how the use of cell phones for work purposes impacts the stress levels of workers. It was concluded that 46.31% show signs of stress. Regarding perceptions about the use of cell phones for work purposes, it was identified that 44.4% of respondents are not satisfied with the use of their personal numbers and devices for work purposes, as they believe the company should provide corporate numbers and guide employees to only use them during working hours. The respondents' perceptions all converge on the idea that the use of cell phones for work purposes needs to be adjusted, as indicated by the data from this research, which suggests that it contributes to increased stress.
Keywords: Stress. Cell Phone Use.
PERCEPÇÕES SOBRE EMPREGABILIDADE E LIFELONG LEARNING ENTRE PESSOAS EMPREGADAS EM UMA CIDADE DO MEIO-OESTE CATARINENSE
Authors: Bragagnolo Sandra Mara , Alves da Luz Rafaela
Published: October 2023

Lifelong learning é um termo inglês que, em tradução livre, significa “aprendizado ao longo da vida”. Trata-se de um conceito que preconiza a educação contínua, ou seja, sustenta a ideia de que os estudos devem ser permanentes, e não apenas durante um período da vida. O mercado de trabalho, volátil e competitivo, exige cada vez mais que o profissional esteja preparado para concretizar uma carreira de sucesso. A intenção deste trabalho é analisar as percepções sobre empregabilidade e lifelong learning entre pessoas empregadas na cidade de Fraiburgo-SC. A natureza da pesquisa é quantitativa, de tipologia descritiva. O método de coleta é um questionário e os dados coletados são analisados a partir de análise estatística com apoio de tabelas. Os resultados apontam que os respondestes atualmente estão fazendo curso de reciclagem profissional (59,4%) e procuram oportunidades de desenvolvimento quando não são oferecidas pela empresa (95,4%). Ainda, acreditam que ter um diploma em nível superior faz diferença positiva na hora de procurar uma boa colocação profissional (87,5%) e buscam aprender continuamente (93,7%). Também é possível verificar que 96,8% procuram realizar funções no trabalho que permitam aprender algo novo. Os resultados confirmam que as pessoas buscam atualização e novos conhecimentos para agregar em sua empregabilidade e gestão de carreira.
Palavras-Chave: Gestão de Carreira. Aprendizagem. Empregabilidade.
 
Abstract: Lifelong learning is an English term that, in free translation, means “lifelong learning”. It is a concept that advocates continuous education, that is, it supports the idea that studies should be permanent, and not just during a period of life. The job market, volatile and competitive, demands more and more that the professional is prepared to achieve a successful career. The intention of this work is to analyze the perceptions about employability and lifelong learning among people employed in the city of Fraiburgo-SC. The nature of the research is quantitative, with a descriptive typology. The collection method is a questionnaire and the collected data are analyzed from statistical analysis supported by tables. The results indicate that respondents are currently taking a professional recycling course (59.4%) and seek development opportunities when they are not offered by the company (95.4%). Still, they believe that having a higher education degree makes a positive difference when looking for a good job placement (87.5%) and seek continuous learning (93.7%). It is also possible to verify that 96.8% seek to carry out functions at work that allow them to learn something new. The results confirm that people seek updating and new knowledge to add to their employability and career management.
Keywords: Career Management. Continuous learning. Employability.
Callus Culture of Aralia cordata Thunb.: Obtaining, Selection of Cultivating Conditions, Somatic Embryogenesis Induction
Authors: Nekrasova D. A. , Povydysh M. N. , Pivovarova N. S. , Sidorov K. O.
Published: October 2023

Introduction. Cell cultures spreads widely in different areas of biology, biotechnology and agriculture. Aralia cordata is a perennial herbaceous plant, which has been listed in Red book of the Russian Federation. Pharmaceuticals which are based on raw materials of Aralia ssp. have valuable types of pharmacological activity and are widely used in oriental medicine. A serious obstacle for resumption of the natural populations is the presence of the period of morphophysiological dormancy in the seeds of the plants, which requires a long-time stratification process. Limitation of the natural geographic range and the combination of biological activities useful for humans make Aralia cordata Thunb. prospective object for in vitro introduction.

Aim. The aim of the study is obtaining of the viable cell culture of Aralia cordata Thunb., investigation of the somatic embryogenesis conditions.

Materials and methods. Pieces of the leaves of Aralia cordata intact plant from Komarov Botanical Institute of the Russian Academy of Sciences were used as a primary explants. Pieces of leaves were sterilized in a 2 % benzalkonium chloride solution for 5 minutes, induction of primary callogenesis was carried out on Murasige – Skoog medium. Nutrient media with different constituents were discovered for choosing one for long-time cultivation of calli. Induction of somatic embryogenesis was carried out on the nutrient media with high auxins content. Ethanol extracts from the intact plant and calli cultures were assayed with HPTLC PRO SYSTEM (CAMAG AG, Switzerland).

Results and discussion. After two weeks of cultivation, the formation of primary callus was observed on the surface of the explants. The Linsmaier – Skoog medium with a reduced amount of sucrose (20 g/l) was recognized as the most suitable medium for long-term maintenance of cultures. Embryoid structures of Aralia cordata have been obtained, now we are continuing to collect analytics data about this process. Qualitative analysis of the extracts showed that callus cultures accumulate triterpene glycosides, their composition is close to that of the intact plant.

Conclusion. A viable strain of callus culture of Aralia cordata Thunb. was obtained, a nutrient medium for long-term cultivation of calli was established. Somatic embryoids have been obtained, and their further development is currently being monitored. A preliminary phytochemical study showed that the composition of the chemical components of calli is close to that of an intact plant.
Application of Thermodynamic Models to Predict the Solubility of Biologically Active Substances
Authors: Stepanov K. S. , Turmanidze G. N. , Sorokin V. V. , Sakharov A. D.
Published: October 2023

Introduction. The choice of solvents for the processes of extraction of biologically active substances from natural raw materials, the processes of purification of natural and synthesized substances by extraction, crystallization and dissolution methods is an important problem of the modern pharmaceutical industry, because a large number of experiments must be performed to determine the optimal solvent or mixture of solvents. To reduce the cost of developing and optimizing the extraction and purification of substances stages, it is proposed to use thermodynamic models at the stage of preliminary solubility assessment. The article investigates predicting the solubility of pharmaceutical substances issue on the example of the technology for isolating hesperidin and glycyrrhizic acid from plant materials.

Aim. Theoretical determination of the dissolving power of various solvents with respect to hesperidin and glycyrrhizic acid.

Materials and methods. The PMUNIFAC and NRTL-SAC thermodynamic models were used to predict solubility. The solubility calculation for the NRTL-SAC model was performed using Aspen Properties V14 software, and for the PMUNIFAC model using PTC Mathcad Prime V6. To evaluate the results obtained using thermodynamic models, a number of experiments were carried out, the object of which was the peel of an orange (dried flavedo and albedo, the degree of grinding is 0.2–0.5 mm, the moisture content is 8 %). The quantitative content of hesperidin was determined by direct spectrophotometry at a wavelength of 290 nm. Statistical data processing was performed using Minitab v20 software (Minitab Inc., USA), differences were considered statistically significant at p < 0.05.

Results and discussion. On the basis of thermodynamic models, the prediction of the solubility of hesperidin and glycyrrhizic acid was made. It has been shown that the solubility can be assessed both in the presence of solubility data according to the NRTL-SAC model, and in their complete absence according to PMUNIFAC. The correspondence of the theoretically calculated data to the experimental data confirms the correctness of the calculations of thermodynamic models. The results of the calculations are evaluated and solvents are recommended that can be used in the technology of isolating hesperidin and glycyrrhizic for the stages of degreasing, extraction and crystallization with the antisolvent.

Conclusion. Using the NRTL-SAC and PMUNIFAC thermodynamic models, the dissolving power of various solvents with respect to hesperidin and glycyrrhizic acid was determined. From the calculation results, a list of solvents was built, ranked by the solubility of the studied substances in them. The resulting list can be used in the development of an industrial technology for the isolation and purification of hesperidin and glycyrrhizic acid. It is shown that the NRTL-SAC and PMUNIFAC models have good prospects for quantitative prediction of the solubility of active substances.
Kapasitas Total Antioksidan dan Uji Toksisitas Ekstrak Bunga Kecombrang (Etlingera elatior (Jack) R.M.Sm)
Authors: Hermawan Faiz Agung , Ferdinal Frans
Published: October 2023

Oxidative stress is imbalance between antioxidant production and the formation of free radicals, which are involved in the development of degenerative diseases. Declining organ function is a symptom of degenerative diseases. The antioxidant helps protect the body from free radicals and prevent oxidative stress. Antioksidan classified into exogenous and endogenous. (Etlingera elatior (Jack) R.M.Sm) flower is known for its antioxidants. This study aimed to establish the toxicity and antioxidant features of kecombrang flower. Total antioxidant capacity test by Blois 1,1 Diphenyl-2Picryhydrazyl  (DPPH) method, toxicity test by Brine Shrimp Lethality Test (BSLT) method. After acquiring simplicia by grinding and aerating the flowers, the extract was obtained by the maceration process using methanol as the solvent and evaporation. The extract was then analyzed. The total antioxidant capacity test showed an IC50 of 931.53 g/mL, indicating that kecombrang flower has a low total antioxidant capacity. Based on the results of the toxicology tests, the LC50 value for the kecombrang flower extract was 612.66 g/mL, indicating that it possessed toxic properties. This study concluded that kecombrang flower extract was shown to have low antioxidant levels and potential antimitotic activity.
Predicted distribution of ‘ua‘u (Hawaiian petrel Pterodroma sandwichensis) nest sites on Haleakalā, Maui
Authors: Adams J , Felis JJ , Klinger R , Kelsey EC , Tamayose J , Kaholoa‘a R , Bailey C , Penniman JF , Learned J , Ganter C , Medeiros J , Chen H
Published: October 2023

Haleakalā National Park and montane areas on east Maui, Hawaiian Archipelago, support critical nesting habitat for endangered ‘ua‘u Hawaiian petrel Pterodroma sandwichensis. Habitat loss, non-native predators, and damage by feral ungulates are limiting factors for ground-nesting petrels at Haleakalā and throughout Hawai‘i. Because nesting habitats differ among the Hawaiian Islands, habitat distribution modeling for Hawaiian petrel has been island specific. Based on 2453 known nest site locations, we provide the first landscape-scale predictive model describing relative abundance and habitat available for nesting petrels throughout upper Haleakalā (1830 to 3055 m). We evaluated (principal components analyses and Pearson’s correlation) 13 spatial landscape and climate predictor variables associated with nest sites and the background landscape followed by random forest modeling to predict nest site density. Six variables (elevation, slope, topographic position index at 2 scales, heat load index, presence-absence ash/cinder, and presence-absence vegetation) indicated nest sites occurred non-randomly throughout the central part of the summit and crater; greatest concentrations were predicted along the crater rim and a ridgeline extending southwest from the summit. Moderately high predicted density occurred in the northeastern and northern crater. Lower elevations to the north, west, and south flanks of Haleakalā had relatively fewer predicted nest sites. Although we focused on higher elevations on Haleakalā, there is no reason to suspect that conservation efforts would not be successful at lower elevations, provided nesting petrels were protected from invasive predators, grazing ungulates, and significant land alteration.
Recombinant Myostatin: Isolation and Use in Vaccines
Authors: Koloskova E. M. , Ezerskiy V. A.
Published: October 2023

Protein myostatin is not only a potential target for therapeutic effects in pathologies of the muscular system, but also a tool for biotechnological regulation of the meat productivity of farm animals. The action of myostatin can be blocked by inducing autoantibody synthesis using recombinant myostatin (rMST) as an antigen. E. coli producer strain Bl21/pET28-MSTN was obtained with a high level of recombinant protein expression in inclusion bodies. Purified rMST was used to immunize sheep and rabbits. Using the created ELISA test system for the detection of antibodies to myostatin in the blood of sheep, it was shown that rMST is immunogenic (the working titer of sera is 1/400–1/800). As a result of vaccination of rabbits over a monthly period, the average body weight and average daily weight gain in animals of the experimental groups was observed to increase compared to the control group.
Experimental Model to Substantiate the Application of New Biologically Active Substances for Correcting Physiological Processes and Functions
Authors: Erimbetov K. T. , Zemlyanoy R. A. , Fedorova A. V. , Obvintseva O. V.
Published: October 2023

In this research, we aim to develop and investigate nanostructured clathrate complexes of 20-hydroxyecdysterone, a rhodanine derivative of 3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one, with various clathrate formers, such as arabinogalactan and β-cyclodextrin. For the first time, an experimental model is proposed to justify their use for the correction of physiological processes and functions, both in normal and pathologic conditions in the animal body. The results obtained substantiate the possibility of regulating metabolic processes by activating signaling pathways associated with cell proliferation.
The Effects of COVID-19 on Pregnancy Outcomes, as well as the Impact on Fetuses and Newborns: Cross-Sectional Study
Authors: Soufizadeh Nasrin , Hajizadeh Farzaneh , Seyedoshohadaei Fariba , Hemmatpour Siroos , Zare Shamsi , Kamalzadeh Ashkan
Published: October 2023

Background: Pregnant women, fetuses, and newborns are at a higher risk of exposure to infectious diseases during outbreaks compared to other populations.

Objectives: The purpose of this study is to investigate the effects of COVID-19 on pregnancy outcomes, as well as the impact on fetuses and newborns in Kurdistan, Iran. The study will cover the period from February 2020 to January 2021.

Methods: We conducted a study in Kurdistan province on 201 pregnant women who were infected with the COVID-19. We gathered relevant information from patients' files using a checklist. We used SPSS software version 21 to calculate the mean and standard deviation for quantitative variables and frequency and percentage for qualitative variables.

Results: The study found that patients had various symptoms including fever, cough, diarrhea, and more. 70% of mothers had fever and cough, while 54% had fever, cough, and myalgia. Positive results were found in CT and PCR tests. Some mothers were hospitalized in the ICU, and there were cases of maternal and infant deaths. Apgar scores were taken with most samples having scores of seven or above at one and five minutes after birth.

Conclusion: Pregnant women are unlikely to pass COVID-19 to their fetus during pregnancy or childbirth. If infected at the end of pregnancy, both mother and newborn seem to have appropriate health outcomes, but individual differences may occur. Pregnant women have the same risk of contracting COVID-19 as non-pregnant individuals.
Pneumoperitoneum in a Patient with Endometriosis and Bilateral Salpingectomy after Sexual Activity
Authors: Kaddoura Rachid , Abdalbari Karim , Ayach Mohammad , Weiss Abdul Kader
Published: October 2023

Pneumoperitoneum commonly occurs due to perforated viscus, yet a minority of cases can occur due to gynaecological causes, particularly following sexual activities. While not yet established, various hypotheses have been posited to explain the development of a spontaneous pneumoperitoneum after sexual intercourse. We herein present a unique case of a woman with a history of endometriosis and bilateral salpingectomy who presented with sudden abdominal pain that started after sexual activity. Subsequently, an emergent diagnostic laparoscopy was deemed necessary yielding no signs of perforation. However, an endometrial island was identified on the stump of the previous right salpingectomy during the procedure. Finally, the most likely cause of the patient’s spontaneous pneumoperitoneum was determined to be secondary to sexual activity and subsequent air transmission through an opening caused by her endometriosis. In conclusion, this report will showcase the importance of considering gynaecological pathologies as potential causes of spontaneous pneumoperitoneum, particularly following sexual activity. We intend to diminish the stigma associated with using sexual history as a diagnostic tool when faced with ambiguous cases of abdominal pain presentations.
Netrin-1 Expression in Uterine Serous Carcinoma and Its Association with Prognosis
Authors: Kefeli Aysegul Ucuncu , Bayrak Busra Yaprak , Tunce Esra Betul , Vural Cigdem , Suyusal Halil İbrahim , Kefeli Umut , Aksu Maksut Gorkem
Published: October 2023

Background/Objectives: Few biomarkers are used to predict the prognosis of serous uterine carcinoma (USC). Netrin-1, may be a promising biomarker candidate. Our aim was to investigate netrin-1 expression in USC tissues and analyze its relevance with disease prognosis.

Material and Methods: The expression of netrin-1 in 48 USC patients’ tissues was examined by immunohistochemistry.

Results: The overall netrin-1 positivity rate was 76%, detected as high expression in 17 (35%), and low expression in 19 (40%) of the patients. Patients suffering from tumors with no expression of netrin-1 (n= 15) had a median OS of 60.0 months (95% CI, 47–98), while low to strong expression (n = 33) was associated with lower median OS of 50 months but this was not statistically significant (95% CI, 58–108; p= 0.531). Also, DFS was not statistically significant between groups. We did not find any difference in OS and DFS when age, tumor stage, histology, tumor diameter, lenfovascular invasion (LVSI), myoinvasion and lymph node metastasis were compared according to netrin-1 expression (p>0.05).

Conclusion: Netrin-1 was found to be expressed in most USC patients, but its expression was not related to OS and DFS.
TÜRKİYE’DE GİG EKONOMİSİNİN İŞGÜCÜ PİYASASINA ETKİSİ: İŞİN OLSUN ÖRNEĞİ
Authors: YURGİDEN Hatip
Published: October 2023

Dünya üzerinde birçok alanın dijitalleşmesi, teknolojik yenilikler ve internetin hızlı gelişmesi insanların yaşam ve çalışma şekillerinde köklü değişiklikler yaratmıştır. Dünyanın küresel bir boyuttan dijital bir boyuta geçmesi, insanların yer ve zaman ayırt etmeden kolay bir şekilde istediği bilgilere ulaşma fırsatı tanımıştır. Dahası 2008 yılında yaşanan Avrupa Borç Krizi ve ardından dünya geneline hızlıca yayılan Covid-19 pandemisi, insanların evlerinde kalarak işlerini yürütebileceği düşüncesini gün yüzüne çıkarmıştır. Uzaktan çalışma fikri insanlara cazip gelerek firmaların ya da hükümetlerin bu alanda hızlı bir şekilde çalışmalar yapmasını zorunlu hale getirmiştir. Böylece bu çalışmayla Türkiye’de büyümeye başlayan gig ekonomisinin işgücü piyasasına etkisi incelenmeye başlamıştır. Bu kapsamda örneklem olarak Türkiye’nin en büyük online işe alım platformu olan Kariyer.net’in mavi yaka istihdamına katkı sağlamayı amaçlayan konum bazlı platformu “İşin Olsun’’ uygulaması seçilmiştir. Çalışma sonucunda, İşin Olsun’un Türkiye’de 78 binden fazla tam, yarı ya da esnek zamanlı (parça başı) iş ilanı ile 10 milyona yakın iş arayan kişiyi karşılaştırarak gig ekonomisine katkı sağladığı düşünülmektedir. Ayrıca, uygulamanın benzersiz özellikleri sayesinde geçici işlerde daha fazla işe almayı açık hale getirebileceği ve istihdamı arttırabileceği tahmin edilmektedir.
KÜRESEL GÖÇ HAREKETLERİNİN ULUSLARARASI İŞLETMECİLİK AÇISINDAN DEĞERLENDİRİLMESİ
Authors: ALADAĞ Ömer Faruk
Published: October 2023

Bu makale, küresel göç ve uluslararası işletmecilik alanına yansımalarını incelemektedir. Küresel göç ve ticari faaliyetlerin kesişme noktasındaki çok yönlü etkilerin, stratejik uyarlamaların ve ortaya çıkan eğilimlerin kapsamlı bir analizini sunmaktadır. Bireylerin sınır ötesi hareketiyle karakterize edilen küresel göç, ekonomik fırsatlar ve jeopolitik olaylardan çevresel değişiklikler ve sosyal isteklere kadar çeşitli faktörler tarafından yönlendirilmektedir. Uluslararası işletmeler de bu süreci şekillendiren aktif katılımcılar olarak demografik değişimler, yetenek hareketliliği, kültürel çeşitlilik ve sosyoekonomik dönüşümlerde pay sahibi olmakta, bunlardan kaynaklanan zorlukların üstesinden gelmekte ve fırsatları değerlendirmektedir. Küresel göçün uluslararası iş dünyası üzerindeki etkileri derin ve geniş kapsamlıdır. Göçmenler, ev sahibi ekonomilere farklı uzmanlık, yenilikçi düşünce ve yeni bakış açıları katabilirken sınır ötesi iş birliğini teşvik etmekte ve kültürel çeşitliliği artırmaktadır. Uluslararası işletmeler için bu etkiler işgücü piyasaları, şirket stratejileri, inovasyon dinamikleri ve yetenek yönetimi alanlarında da kendini göstermektedir. İleriye baktığımızda, teknoloji odaklı hareketlilik, nitelikli göçmenlik rekabeti ve iklim kaynaklı göç gibi yeni trendler uluslararası işletmeciliği yeniden şekillendirmeye hazırlanmaktadır. İşletmeler, sürekli gelişen küresel ortamda başarılı olmak için uyarlanabilirliği, kültürel duyarlılığı ve teknolojik yenilikçiliği benimseyerek uyum sağlamalıdır. Yenilikçilik, ekonomik büyüme ve toplumsal kapsayıcılık yoluyla işletmeler ve toplumlar küresel göçün olumlu etkilerinden yararlanabilirler.
Analisis Wacana Kritis pada Novel Tempurung Karya Oka Rusmini dan Implikasinya dalam Pembelajaran
Authors: Hardinanto Eko , Dwinata Anggara
Published: October 2023

This research aims to find, describe, interpret, and explain the ideology of women against the domination of patriarchy, myths and customs in Oka Rusmini's Tempurung novel as teaching materials for senior high school students. The approach used in this research is descriptive qualitative. This study uses critical discourse analysis as a blade of analysis. The data source in this study is the Tempurung novel by Oka Rusmini, published by PT. Gramedia Widiasarana Indonesia in 2017. The steps taken in data collection are as follows: read over and over the whole novel to understand its contents completely, record important words, sentences, or data related to the problem under study, record and collect relevant theories related to research, conduct research based on existing theories, and draw conclusions. The steps in data processing are as follows: data description, data classification, data analysis, data interpretation, and evaluation. The data analysis techniques used were: processing and presenting data, reading the entire data, coding the data and descriptions, interpreting and explaining the data. The findings in this study are that the Tempurung novel is a reflection of the ideology of women's resistance to the patriarchal system, the ideology of fighting against myths created by patriarchy, and the ideology of resistance to tradition. The resistence is done to obtain equality in their rights and obligations, so that women can get freedom like men. The female characters in the Tempurung novel fight against the domination of patriarchy, myths, and their own cultural customs in order to realize equal rights between men and women. These findings can be used in the creating of text-based teaching materials as learning materials in the senior high school. The application of the concept of critical discourse analysis in learning will contribute to studentsâ€™ critical thinking in solving various problems in life.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK BERBASIS NUMBERED HEADS TOGETHER PADA MATERI ZAT ADITIF KELAS VIII
Authors: Deswita Aji Astutik  , Oktaffi Arinna Manasikana
Published: October 2023

Penelitian ini bermaksud untuk membuat dan mengukur valid, praktis dan efektif LKPD berbasis numbered heads together pada materi zat aditif kelas VIII. Metode penelitian mengintisarikan pengembangan model ADDIE yang dilakukan lima tahap ialah analyze, design, development, implementation, dan evaluation. Hasil dari validasi LKPD oleh dua validator ahli dan pendidik didapatkan skor rerata sebesar 77,8% dengan kategori valid. Hasil kepraktisan berdasarkan keterlaksanaan penggunaan LKPD didapatkan skor rata-rata 88,6% dan hasil respon positif peserta didik didapatkan skor rerata sebesar 92.8% dengan kelompok sangat praktis. Hasil keefektifan mengolah ketuntasan hasil belajar peserta didik didapatkan skor rerata78,7% dengan kategori efektif.

Kata Kunci : Pengembangan LKPD, Model Numbered Heads Together, Zat  Aditif.
Kepraktisan dan Efektivitas Media Flashcard Modifikasi pada Materi Interaksi antar Makhluk Hidup Bagi Siswa SMP/MTs
Authors: Qurrotul Uyuni  , Noer Af'idah  , Fajrul Falah
Published: October 2023

Permasalahan dalam Pendidikan sering terjadi karena proses pembelajaran yang lemah, yaitukurangnya ketertarikan siswa pada saat proses pembelajaran. Hal tersebut disebabkan karenakebanyakan guru mengarahkan siswa untuk memahami teori saja. Salah satu solusi daripermasalahan tersebut yaitu adanya media pembelajaran. Penelitian ini bertujuan untukmendeskripsikan hasil pengembangan media flashcard modifikasi berdasarkan kepraktisan danefektivitasnya. Penelitian ini merupakan penelitian pengembangan yang menggunakan modelADDIE yang merupakan singkatan dari analize, design, development, implementation, andevaluation. Subjek penelitian ini yaitu siswa SMP kelas VII. Data kepraktisan didapatkan dariobservasi siswa ketika menggunakan media serta penyebaran angket respon siswa setelahmenggunakan media. Kemudian data efektivitas didapatkan dari postest siswa setelahmempelajari materi interaksi antar makhluk hidup dengan manggunakan media flashcardmodifikasi. Dari hasil penelitian ini didapatkan bahwa media flashcard modifikasi sangat praktisdengan rata-rata skor 93,2% dan sangat efektif dengan skor rata-rata 87,1%. Dengan demikianmedia pembelajaran ini sangat baik digunakan dalam materi interaksi antar makhluk hidup.