bluuebunny/crossref_metadata_2025 huggingface dataset:
NEW MONOCLONAL ANTIBODIES TO THE PROSTATE-SPECIFIC ANTIGEN: OBTAINING AND STUDYING BIOLOGICAL PROPERTIES
Authors: Galkin Alexander , Komar Anatolii , Gorshunov Yuri , Besarab Alexander , Soloviova Valentine
Published: June 2020

Original set of 15 clones of hybridomas producers of monoclonal antibodies (mAbs) to prostate-specific antigen (PSA) (using as a source of lymphocytes of mice of inbred strains NZB and Balb/c) was obtained. The activity in ELISA, affinity constant and titer in the culture fluid of the mAbs obtained from NZB mice are higher compared to the mAbs obtained from the Balb/c mice splenocytes. Conjugates of obtained mAbs with horseradish peroxidase were synthesized, and it allowed performing comparative epitope characterization of the resulting set of mAbs. Studied mAbs are directed to 4 epitopes of PSA molecule: 2 mAbs interacting with one of the epitopes showed cross-activity with PSA-related protein – human kallikrein 2; 2 mAbs of the same epitope specificity blocked the enzymatic activity of PSA; mAbs of the remaining two epitopes either did not affect PSA chymotrypsin activity at all, or this inhibitory effect was not significant. The obtained mAbs recognize antigenic determinants that are not screened when interacting with α1-antichymotrypsin, as well as those that are localized in the places where α1-antichymotrypsin interacts with PSA. Within each of the given two mAbs groups, there are antibodies belonging to different epitopes, which give prospects for the further use of the obtained mAbs in immunoassay and immunobiotechnology. Two alternative methods for determining of the mAbs constants of affinity (by Friguet and Scatchard) are comparable (for determination of the affinity constants of anti-PSA antibodies): coefficient of linear correlation between the affinity constants defined by different methods was 0.90.
THE EFFECT OF MILD TEMPERATURE STRESS ON THE OVARIAN ACTIVITY IN COWS
Authors: Bezdíček J. , Stádník L. , Makarevich A. , Kubovičová E. , Louda F. , Hegedušová Z. , Holásek R.
Published: June 2020

The aim of this study was to evaluate the effect of mild temperature stress on ovarian activity (corpus luteum count; transferable embryos; morulae and blastocysts) in cows. The evaluation included 54 Holstein cows superovulated and flushed at one farm in the Czech Republic in three different temperature periods in flushing day (mild hot season THI = 75.66; season with optimal temperature THI = 68.85; season with lower temperature THI = 45.56). The data were analysed using the PROC GLM of Statistica®. The statistical model included the effect of season and other factors (age; condition; breeding value) on the studied reproduction traits. The results showed significantly higher ovarian activity in the cooler period of the year than in periods of mild temperature stress. There was also a non-significantly better reproduction result in younger animals under optimal condition.
OPTIMIZATION OF THE CULTURE MEDIUM COMPOSITION TO INCREASE THE BIOSYNTHESIS OF RECOMBINANT HUMAN INTERLEUKIN-7 IN ESCHERICHIA COLI
Authors: Motronenko Valentyna , Lutsenko Tetiana , Galkin Alexander , Gorshunov Yuriy , Solovjova Valentyna
Published: June 2020

The purpose of the work was to rise of biosynthesis of the human recombinant interleukin-7 (rIL-7) in E. coli by optimizing the quantitative and qualitative composition of the culture medium. As a result of optimization of the quantitative composition of organic and mineral components of the culture medium using the matrix of planning a fractional factor experiment, it was possible to increase the synthesis of rIL-7 by 1.3 times. It was proved that the use of supplements to the culture medium in the form of extracts of Clivia miniata and Zephyranthes grandiflora (0.5-1.0%) stimulated the rIL-7 synthesis in recombinant bacterial cells in 1.3-1.4 times. The use of phytoextracts at a concentration of 5.0% and more caused an inhibitory effect on the producer biosynthetic properties. It has been established that the modulation of the biosynthetic activity of recombinant bacteria is due to the interaction of the biologically active substances of plant extracts with the surface structures of the bacterial cell, namely, porins (OmpC and OmpF proteins). The stimulating effect of vitamin K1 (15-25 mg per 1 ml of culture medium) in the liposomal form was proved; such approach allowed increasing the synthesis of rIL-7 in 1.34-1.39 times. And the use of liposomal form of plant extracts as an approach to increasing the bioavailability of biologically active substances is not appropriate.
THE EFFECT OF HONEY VARIETY ON THE QUALITY OF HONEY POWDER
Authors: Tomczyk Monika , Zaguła Grzegorz , Tarapatskyy Maria , Kačániová Miroslava , Dżugan Małgorzata
Published: June 2020

The conversion of raw honey into powder can increase its usage in food industry but the health properties of obtained powder in relation to chemical composition of honey have been not studied since now. The aim of the study was to check the influence of botanical origin of honey on the quality of honey powder produced by spray drying method. Nine honey samples: honeydew (3), multifloral (3) and acacia (3) were transformed into honey powder using DC1500 dryer (Unimach, China). Analysis of honey powders and comparatively raw honeys covered: physicochemical parameters (moisture content, titratable acidity, pH, electrical conductivity, sugar profile (HPLC) and calorific value), bioactive compounds determination (antioxidant activity (DPPH and FRAP tests), phenolic compounds, mineral composition (ICP-OES) as well as microbiological purity and antibacterial activity. The experiments have shown that honeydew honey powder was characterized by the strongest antioxidant activity and the richest mineral composition, whereas the weakest properties for acacia honey were observed. Moreover, sugar profile of obtained powders was similar to raw honey. It was found that the quality of honey powder was directly dependent on the quality of raw honey.
First record of Stylostomum ellipse (Dalyell, 1853) (Platyhelminthes, Polycladida) from the Pacific Ocean
Authors: Tsuyuki Aoi , Oya Yuki , Kajihara Hiroshi
Published: June 2020

The polyclad flatworm Stylostomum ellipse (Dalyell, 1853) has hitherto been recorded from the Antarctic region, Mediterranean Sea, Patagonian region, Scandinavia, South Africa, and South Georgia Island. In this study, we report S. ellipse for the first time from the Pacific Ocean based on specimens collected in Hokkaido, northern Japan. Our specimens are morphologically identifiable as S. ellipse, but may represent a biologically different species from a population of the Mediterranean Sea. This is because, based on the previous genetic data of other cotylean species, the observed uncorrected p-distance 0.02160 between the two distinct populations in terms of a partial 972 bp region of the 28S rDNA sequence may be great enough to separate the species biologically.
First record of Western Gull, Larus occidentalis Audubon, 1839 (Charadriiformes, Laridae), for Honduras
Authors: van Dort John
Published: June 2020

I present the first record for Honduras of Western Gull, Larus occidentalis Audubon, 1839, a species found on the Pacific coast of southern Canada, the United States and northern Mexico. An adult was present for at least two weeks at an estuary in the Gulf of Fonseca in southern Honduras. This observation represents the third record of this species for Central America.
Jewellery from Burial 2 Kurgan 1 Filippovka 1 Cemetery: Manufacturing Techniques, Purpose and Semantics of Images
Authors: Anikeeva Olga , Kolganova Galina
Published: June 2020

The article is dedicated to the publication of the unique jewelry which was found in the untouched noble female’s grave-pit of the Early Sarmatian elite burial ground located at Southern Urals. It stands out with an unordinary complicated construction, polychrome style, a variety of materials and techniques used in its manufacture, central disc containing cloisonne artwork. Analysis of the item’s burial context convincingly showed this item was not worn as a decoration in social life, but it was the precious relic used in religious ceremonies and ritual practices for short periods of time. A detailed study of manufacturing technology allows us to reconstruct the fastening ways and application methods for this jewelry. The search of analogies for images placed on the central medallion, made it possible to clarify its compositional semantics. Its central character is the sacred tree, guarded by the divine power of “khvarenah” deity. “Khvarenah” is presented by two guises - the winged sun disc and the sacred Veraghna birds. General meaning of the ritual reflects the idea of increasing fertility: ensuring the well-being and increasing offspring numbers, health, wealth and prosperity of the family. New Assyrian compositional scheme used in the medallion. It appeared at the beginning of the IX century BC and actively spread in Urartu and pre-Achaemenid Media since the VIII-VII centuries BC. This relic was found in the early nomadic burial site dating back to the IV century BC. All these show the significant continuity of ancient Iranian religious cults. They continue to exist in the satrapies of Achaemenid Iran, they are perceived by the elite of the Sarmatian tribes of the Southern Urals and they spread in a nomadic environment.
Yurta-Shaped Dwellings and Buildings of the X-XII Centuries in Samosdelka Hillfort
Authors: Boldyreva Ekaterina , Vasilyev Dmitriy , Zilivinskaya Emma
Published: June 2020

The article is devoted to the publication of a number of Yurta-shaped dwellings of the X-XII centuries, discovered during excavations at the Samosdelka hillfort in the Volga Delta and at Left-Bank Samosdelka settlement, adjacent to the mentioned hillfort. The hillfort is known as the place of the supposed localization of the medieval cities of Saqsin (XI-XIV centuries) and Itil (IX-X centuries). The article briefly describes the planigraphy of the archaeological monument and the conditions of four circular dwellings discovering. Three of them belong to the X century and date back to the Khazar era. One dwelling has a more complex structure and belongs to the heyday of the city of Saqsin (XI-XII centuries). The design features of dwellings are analyzed, and archaeological and ethnographic analogies are given to both dwellings as a whole and to their individual elements. Two early circular buildings had no traces of a fireplace inside, so we can consider them not as dwellings, but yurta-shaped structures for household purposes. There were fireplaces in one building of the X century, found on the periphery of the Left-Bank settlement, as well as in the construction of the XI-XII centuries in the Central part of the hillfort. We can rightfully call these structures yurta-shaped dwellings. The last building has the most complex design, it is made using burnt square-shaped bricks for lining the edge of the laying bench and the walls in the basement. Bricks were also used as supports for poles and pillars. The presence of bricks indicates the time of the appearance of this dwelling after dismantling the hillfort citadel walls for getting building materials out of them. The discovered dwelling is a confirmation of the words of Abu Hamid al-Garnati, who wrote that in the city of Saqsin, the noble Oguzes had large “tents” like domes that can accommodate a large number of people. We can find direct analogies to such dwellings in the construction of Kazakh yurta-shaped buildings of the XIX - early XX centuries.
Investigation of the Palaeolithic and Mesolithic Sites in the Don Basin on the Territory of Volgograd Region
Authors: Remizov Stanislav
Published: June 2020

The locations of the Stone Age on the Volgograd region territory have been known since the beginning of the XIX century. However, purposeful Stone Age sites explorations had only started after the Sukhaya Mechetka site was discovered by A.P. Koptev and M.N. Grischenko in 1951. The data accumulated on series of stratified sites in Volgograd Region makes it possible to outline two significant groups of them. One of the groups belongs to the Lower Volga basin. The other group is associated with the ramified network of gullies and ravines and multiple tributaries of the Don. The Don is the fourth longest river on the Russian Plain; its basin taken in the Volgograd Region is several times larger than the Volga basin taken in the area. The relatively flat landscape of the Don plain, saturated with small rivers, gullies and ravines, as well as stone raw materials available for mining, have been creating favorable conditions for human habitation since the Middle Paleolithic. The well-known Paleolithic and Mesolithic sites are found both in the watersheds and in the floodplain-terrace areas of the Middle Don. The near-mouth section of the Kurmoyarsky Aksai river – the Don tributary in Kotelnikovo District – and the surroundings of Kremenskaya village in Kletskaya District are standing out in terms of being studied. The stone industry detected in the lower layers of the multilayered site Schlyakh indicates that the Don plain was inhabited by people during the Middle to the Upper Paleolithic transition. The prospects of further searches for Stone Age sites in the Middle Don Basin had already been proven by the discovery of at least forty sites in previous decades. Further archaeological research will help to discover new stratified sites with impressive collections of stone and bone items, which will make it possible to draw analogies with synchronous sites in the territories adjacent to the Volgograd region.
Secondary care clinical supervisors’ views on the tensions between education and service delivery in medical student clinical placements
Authors: Gray James
Published: June 2020

This article was migrated. The article was not marked as recommended. PurposeIncreased external scrutiny on medical education has led to a need to ensure that clinical placements are delivering high quality education in an increasingly high pressure environment. Clinical supervisors provide the oversight of education delivered to undergraduate medical students in the clinical environment yet their views are seldom sought. This piece of work seeks to explore their views on the tension between delivery of education and patient care to support the development of placement based education.Materials and MethodsThis study utilised interpretative phenomenological analysis (IPA). The study involved interviews with nine clinical supervisors in medical specialities with a mix of age and gender.ResultsConflicts between need of care provision and student education were highlighted and potential solutions including the students themselves were explored with variable views on potential and any possible benefit. Supervisors perceived a need for closer dialogue between the Medical School and the Hospital Trusts themselves.ConclusionSupervisors have developed pedagogical methodologies in line with current best practice developed, through necessity, in a high pressure clinical environment. More needs to be done to maintain quality in an increasingly pressurised care environment.
Do History Lessons Ever Pay off? A Diplomat’s Memoir
Authors: Braithwaite Rodric
Published: June 2020

Sir Rodric Braithwaite was educated at Christ’s College, University of Cambridge, from where he went to serve in HM Diplomatic Service, having worked in Jakarta, Moscow, Washington, Warsaw, Rome, and Brussels, where he was a member of the British delegation to the European Community. From 1988 to 1992, Sir Rodric served as HM Ambassador in the Soviet Union during the decisive years of the Perestroika and the first British ambassador in Russia. Subsequently, he was appointed foreign policy adviser to the Prime Minister in the second John Major ministry and chaired the UK Joint Intelligence Committee between 1992 and 1993. He was appointed Knight Grand Cross of the Order of St Michael and St George (GCMG) in 1994. As a career diplomat, Sir Rodric gained decades of insight into the troubled relations between Russia and West, having taken part in numerous negotiations on arms control. His affinity with the decision-making circles in both Russia and Britain alongside with the mastery of the Russian language allow him to skillfully dissect the underlying causes of ups-and-downs in Moscow’s relationship with the West, employing the works of both English- and Russian-speaking analysts. Among his recent books are Across the Moscow River (2002), Moscow 1941: A City and Its People at War (2006), Afgantsy: The Russians in Afghanistan, 1979–1989 (2012), Armageddon and Paranoia: The Nuclear Confrontation (2017). In this essay, Sir Rodric reminisces of the years spent as a diplomat and provides his view on the usefulness and applicability of historical lessons while devising a foreign policy course.
“The Semantic Environment” of the Late Dramatic Works of A. Platonov
Authors: Proskurina Elena
Published: June 2020

This review raises a set of important issues. The use of contextual, motif, and “evidence-based” methods make it possible to identify hidden semantic layers which are hard to discern in Platonov’s late plays at first. The authors manage to demonstrate both the peculiarities of the plot of Platonov’s late dramas and their connection with the writer’s creative work as a whole. Particularly important is the autobiographical context which significantly enriches the “semantic environment” of the works analysed. It is based on Platonov’s family drama related to the arrest and premature death of his son Platon. The study reveals various ways of inclusion of the “son motif ” in the plays Voice of the Father, A Magical Being, and A Student of the Lyceum. The analysis of the play Noah’s Ark turns out to be less interesting, which is largely due to the fact of its being unfinished and, thus, lacking artistic perfection. The stylistic originality of Platonov’s late creative work and its artistic distinction from the works of the 1920s – 1930s remain outside the authors’ framework of reflection. This range of issues may serve as a future focus of study.
The Impacts of Self-expression on the Self-efficacy of Intellectually Disabled Children Who Participated in a Art Integration Movement Program
Authors: Jang Sun-Mi
Published: June 2020

PURPOSE: The purpose of this study is to analyze how the self-expression of intellectually disabled children participating in movement programs applied at art integration education affects their self-efficacyMETHODS: To investigate the effects of the art-integrated movement program, 20 students with a second-grade intellectual disability were recruited from 1st grade to 4th grade of a special school in B metropolitan city. Ten students that applied for the dance program were assigned the art-integrated movement program, whereas the other students were who did not participate in the dance class but participated in a school program (music, art, and physical education class) were assigned the control group. Each of the classes were consists of 40 minutes sessions per week (two times/week) for a period of 12 weeks. Data were compiled and analyzed by SPSS window program (Ver. 21.0). Additionally, regression analysis was conducted to analyze the effects of self-expression on self-efficacy.RESULTS: Children with intellectual disabilities who participated in the art integration movement program had an impact on their confidence in contents self-expression (t=3.087. p<.01) and voice self-expression (t=2.766, p<.01). contents self-expression (t=3.940, p<.001) affected self-regulating efficacy. and contents self-expression (t=4.057, p<.001) had a positive effect on the preference to taskCONCLUSIONS: The movement program that applied art integrated education suggests that self-expression of children with intellectual disabilities is an effective education to increase self-efficacy. A multifaceted study that is practically applicable in the field of special education is needed.
The Feasibility of Hospital-based Exercise Program on the Level of Physical Activity and Body Composition in Cancer Survivor: An Exploratory Feasibility Study
Authors: Lee Mi Kyung , Byeon Ji Yong , Chung Jae Youn , Jeon Justin Y.
Published: June 2020

PURPOSE: Although physical activity may reduce the risk of cancer recurrence and risk of mortality in cancer patients, majority of cancer survivors are still remained physically inactive. Since most of cancer patients visit their oncologists on a regular basis, it would be ideal to provide exercise counselling program along with their hospital visit. However, the feasibility of hospital based exercise counselling program has not been tested. Therefore, the purpose of this exploratory study was to evaluate the feasibility of hospital-based exercise counselling program on the level of physical activity and body composition in cancer survivors.METHODS: Among 118 cancer survivors underwent exercise counselling program at the cancer prevention center of university affiliated hospital, 47 cancer survivors (mean age, 51.8 years) revisited after an 8-week. At baseline and after 8 weeks, the level of physical activity and body composition were measured.RESULTS: Compared to their baseline value, we observed significant increase in walking (baseline vs. 8 weeks: 170.7±197.8 vs. 362.2±343.4 minutes/week, p<.05) and frequency of resistance exercise (baseline vs. 8 weeks: 0.21±1.2 vs. 2.5±2.5 day/week, p<.05). Percent body fat was decreased (baseline vs. 8 weeks: 30.3±9.6 vs. 29.7±9.5%, p=.025) and skeletal muscle mass was increased at the 8th week follow up visit compared to their baseline value (baseline vs. 8 weeks: 22.9±3.7 vs. 23.2±3.8 kg, p=.019).CONCLUSIONS: The hospital-based exercise program was feasible intervention to increase the level of physical activity and improve body composition in cancer survivors. Considering that the current study is not a randomized controlled trial and also small portion of cancer survivors returned to the follow up test, the efficacy of this exercise counselling program should be tested with proper study design.
COVID-19: Uma leitura geográfica das diferenciações patológicas
Authors: Rocha Pedro Henrique , Trindade Helena , Neves Rafaela Pinheiro de Almeida , Romão Elinton Fábio , Lima Laiza
Published: June 2020

Este artigo busca, por meio da pandemia de Covid-19, compreender por uma leitura geográfica qual elemento melhor se aplica na explicação das diferenciações patológicas. Visto o histórico epidêmico/pandêmico da sociedade ocidental-moderna, cenários patológicos não são novidades para os homens e mulheres. Contudo, mesmo que as principais doenças que atingiram a humanidade se enquadrem em um perfil geográfico-epidemiológico semelhante, o raio de ação que cada uma adquire parece influenciar na reverberação política, social, cultural e etc.
COVID-19: UNCOVERING INDIVIDUALITY
Authors: Rosa-Freitas Maria Goreti , Muruci-Cruz Carolina , Dale Luiz Fernando , Cruz Luis Eduardo da , Kalil Jorge
Published: June 2020

SARS-Cov-2 is a virus easily transmitted by air and fomites causing  acute severe respiratory syndrome. Severity in some cases requires hospitalization and complex expensive intensive care treatments. Its rampant contagious led to a a fearful pandemic affecting the whole world with millions of infected humans and almost half a million deaths in a few months in the beginning of 2020 (until June 17, 2020). SARS-Cov2 is likely to have been spilled over from natural sylvatic cycles in bats from China.
Our purpose is to comment on the human individual immune inflammatory responses to the infection of SARS-Cov2 and the reflections of these individual immunoinflammatory profiles on patterns of the severity of the disease, time for therapeutical intervention, pathogenesis, candidate drugs and indicative comparative drug prices for covid-19.
Efficient treatment  for covid-19 may require: 1) early disease detection, 2) a combination of drugs being used for 3) targeting the virus replication cycle and 4) specific/ individualized drug treatment for given immunoinflammatory human profile responses in a 5) timely manner.
Specific serum immuno-markers of covid-19 affected individuals at onset, in the follow-up, and in the resolution of the immunoinflammatory storm during the course of the disease may lead to individualized therapeutics with better outcomes. 
Covid-19 is unlikely to be the last emergent human disease with fast pandemic potencial. To gather knowledge on the human host profiles and immunoinflamatory responses is an opportunity that could pave the way to faster, more efficient strategies to tackle upcoming diseases.
Synthesis and electrical properties of La0.8Ca0.2Ti0.8Sc0.2O3−δ perovskite for energy applications
Authors: Bradha M , Kavitha K , Vijayaraghavan T , Yuvaraj S , Ashok A M
Published: June 2020

La0.8Ca0.2Ti0.8Sc0.2O3−δ (LCTSO) complex perovskite was synthesized through the sol–gel synthesis method. The structural and electrical properties of LCTSO were investigated in this study. X-ray diffraction analysis revealed single-phase orthorhombic crystal structure formation along with a slight change in the unit cell volume after doping with calcium (Ca) and scandium (Sc). The morphology of the sintered pellet of LCTSO was studied through scanning electron microscopy and transmission electron microscopy techniques. The alternating-current impedance spectroscopy technique was used to study the total conductivity of the materials from 300 to 800°C in air atmosphere. The substitution of calcium (Ca2+) and scandium (Sc3+) ions in the higher-valent cationic sites resulted in the creation of oxygen vacancies in the lattice. The created oxygen vacancies provided an energy barrier for charge diffusion, which led to an increase in the conductivity of LCTSO, with a maximum value of 2.71 × 10−3 S/cm at 750°C. The synthesized materials exhibit enhanced mixed conductivity compared with the undoped LaTiO3−δ and can be suitable for many energy generation applications, particularly for solid oxide fuel cells.
Therapeutic Effect of Adipose Derived Mesenchymal Stem Cell Transplantation in Reducing Restenosis in a Murine Angioplasty Model
Authors: Cai Chuanqi , Kilari Sreenivasulu , Zhao Chenglei , Simeon Michael L. , Misra Avanish , Li Yiqing , van Wijnen Andre J. , Mukhopadhyay Debabrata , Misra Sanjay
Published: June 2020

Significance Statement

The arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis, but several studies have shown that the primary patency rate at 1 year is approximately 60%. Percutaneous transluminal angioplasty (PTA) is the first line of treatment for AVF stenosis. However, the rate of restenosis after angioplasty is high and the primary patency rate after PTA treatment in AVFs at 6, 12, and 24 months is 61%, 42%, and 35%, respectively. Currently, no durable therapies prolong patency after angioplasty. This paper describes the use of adipose-derived mesenchymal stem cells to reduce stenosis after PTA treatment in a murine AVF model and provides rationale for potential clinical use.

Background

Percutaneous transluminal angioplasty (PTA) is the first line of treatment for stenosis in the arteriovenous fistula (AVF) created to provide access for hemodialysis, but resenosis still occurs. Transplants of adipose-derived mesenchymal stem cells (AMSCs) labeled with green fluorescent protein (GFP) to the adventitia could reduce pro-inflammatory gene expression, possibly restoring patency in a murine model of PTA for venous stenosis.

Methods

Partial nephrectomy of male C57BL/6J mice induced CKD. Placement of the AVF was 28 days later and, 14 days after that, PTA of the stenotic outflow vein was performed with delivery of either vehicle control or AMSCs (5×105) to the adventitia of the vein. Mice were euthanized 3 days later and gene expression for interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha TNF-α) analyzed, and histopathologic analysis performed on day 14 and 28. GFP (+) AMSCs were tracked after transplantation for up to 28 days and Doppler ultrasound performed weekly after AVF creation.

Results

Gene and protein expression of IL-1β and TNF-α, fibrosis, proliferation, apoptosis and smooth muscle actin decreased, and the proportions of macrophage types (M2/M1) shifted in a manner consistent with less inflammation in AMSC-transplanted vessels compared to controls. After PTA, AMSC-treated vessels had significantly higher wall shear stress, average peak, and mean velocity, with increased lumen vessel area and decreased neointima/media area ratio compared to the control group. At 28 days after delivery, GFP (+) AMSC were present in the adventitia of the outflow vein.

Conclusions

AMSC-treated vessels had improved vascular remodeling with decreased proinflammatory gene expression, inflammation, and fibrotic staining compared to untreated vessels.
Tracheobronchopathia osteochondroplastica: a case report
Authors: SÜNNETÇİOĞLU Aysel , ÇELİKEL Maşuk , ERTEN Remzi , COBANOGLU Ufuk
Published: June 2020

AbstractTracheobronchopathia osteochondroplastica (TO) is a
rare benign condition, characterized by
the presence of multiple cartilaginous and/or osseous  submucosal nodules protruding into  of the tracheobronchial lumen. In
general, tracheobronchopathia
osteochondroplastic(TO) is diagnosed
incidentally during bronchoscopy or autopsy and is not associated with a
specific disease. it can be asymptomatic or present with non-specific
respiratory symptoms. We present a
case of a 62 year-old female with
the dry cough  who
was diagnosed with TPO by flexible bronchoscopy.
Dinámicas de la relación América Latina y China: análisis clúster, 2005 – 2018
Authors: Wong Sara A. , Valverde Ivanna , Silva Carlos A.
Published: June 2020

La literatura ha discutido la simbiosis entre préstamos de financiamiento otorgados por China a América Latina y las exportaciones de esta región hacia China. Este trabajo contribuye con la literatura al respecto, proveyendo evidencia empírica sobre la relación entre América Latina y China mediante la creación de una tipología de países basada en diferentes aspectos claves, como comercio, dependencia de commodities, deuda, medio ambiente e institucionalidad, en cuatro años a través del tiempo (2005, 2010, 2015 y 2018). Se toma en cuenta la dependencia de países al financiamiento proveniente de China —dado el escaso acceso a los mercados internacionales— y cómo aspectos de corrupción y estabilidad del gobierno pueden afectar dichas dinámicas. El contraste entre países e indicadores permite mostrar que la relación entre China y la región latinoamericana conlleva diferentes aspectos que van más allá del comercio bilateral.
Asia, la Cuarta Transformación y el cambio de poder global
Authors: Laborde Adolfo Alberto , Maldonado Marcela
Published: June 2020

El presente trabajo tiene como objetivo principal ubicar los intereses nacionales mexicanos dentro de su política exterior, en el contexto de la transformación que hoy se experimenta en México, denominada la Cuarta Transformación —4T—, considerando los cambios en el equilibrio de poder global, así como exponer alternativas en la materia que coadyuven a cumplirlos. Partiendo de la importancia de la diversificación de las relaciones económicas comerciales con el exterior como elemento clave para dejar de depender del mercado de Norte América, que de acuerdo a la Secretaría de Economía (2019) en México, las exportaciones mexicanas hacia el mercado estadounidense representaron 76% del total en el año 2018. De ahí que el presente trabajo parte del supuesto de que a pesar de que la diversificación política y económica del país es una necesidad, aún no hay estrategias claras frente a las propuestas vertidas por nuestros principales socios en el mundo, especialmente los de Asia (China, Corea del Sur y Japón), que recientemente han mostrado un interés en profundizar sus lazos con México. Para ello, se realizará un análisis bajo el enfoque neorrealista de las relaciones internacionales, de las fuentes del poder de Joseph S. Nye Jr. (2011), así como de la teoría de la transición de poder Tammen (2000).
Atendimento odontológico em tempos de COVID-19: compartilhando boas práticas protetivas e de biossegurança
Authors: Moraes Daniela Costa , Galvão Daniela Cristina Diniz Ferreira , Ribeiro Neiana Carolina Rios , Oliveira Lisia Mariana Silva de , Azoubel Maria Cecília Fonsêca , Tunes Urbino da Rocha
Published: June 2020

INTRODUÇÃO: Durante a pandemia da COVID-19, os cirurgiões-dentistas foram classificados como categoria profissional de alto risco à infecção e transmissão de SARS-Cov2, devido à proximidade da face do paciente bem como pela realização frequente de procedimentos geradores de aerossol. A transmissão desse patógeno durante procedimentos odontológicos pode ocorrer pela inalação de aerossóis/gotículas de indivíduos infectados ou pelo contato direto com membranas mucosas, fluidos orais ou instrumentos e superfícies contaminadas. Ciente dos riscos inerentes ao exercício dessa profissão e diante do cenário mundial, diversas recomendações têm sido sugeridas para cirurgiões-dentistas e estudantes de Odontologia no atendimento aos pacientes. Embora a biossegurança já faça parte da rotina do cirurgião-dentista, o contexto de pandemia pressupõe a necessidade de revisitar os princípios norteadores dessa prática e conhecer as particularidades impostas por um vírus até então desconhecido. OBJETIVO: Este trabalho tem como objetivo propor e discutir medidas de enfrentamento à disseminação do SARS-Cov2 no ambiente odontológico, enfatizando os cuidados necessários para a proteção dos profissionais e pacientes, no contexto da Odontologia no Brasil. MÉTODOS: Para tanto, foi realizada uma compilação de medidas e recomendações baseadas nos principais documentos técnicos publicados nos últimos meses pelas autoridades de saúde. RESULTADOS: As principais recomendações incluem a triagem dos pacientes, distanciamento social, ajustes em equipamentos de proteção individual (EPIs) e o emprego de produtos e técnicas de desinfecção adequados. CONCLUSÃO: Este trabalho apresentou, de forma objetiva e prática, medidas essenciais para atuação odontológica durante a pandemia da COVID-19, ressaltando a provável permanência dessas ações e a importância de adotar medidas rígidas, adequadas e exequíveis.
Left-Handed and Right-Handed Fencers in the International Sports Arena: Specifics of Their Competitive Activity and Features of Identification
Authors: Shynkaruk Oksana , Ulan Alina , Bondar Anna , Iakovenko Olena , Strohanov Serhii , Pavlenko Iurii , Goncharenko Ievgen , Krasnianskiy Kyrylo
Published: June 2020

Research purpose: To study the features of left-handed and right-handed fencers’ competitive activity, to justify the tendency of increasing the representation of left-handed fencers in the international sports arena and to substantiate the need to take into account the functional asymmetry of fencers in the initial stages of sports training. Material and Methods. 54 international competitions and 2,395 athletes were studied. The survey was attended by 25 coaches. The study of individual profiles of asymmetry involved 9 qualified fencers. During the research, the following methods were used: analysis of scientific and methodological literature and materials from the Internet, analysis of competition protocols and video analysis, sociological methods of research, pedagogical observation, pedagogical testing, methods of mathematical statistics. Results. Among the features of competitive activity of fencers with different leading extremities are: increase in the number of various attacks and counterattacks of the right-handed athletes and widespread use of complex and more varied technical and tactical actions, while the speed of performing techniques and actions can be reduced due to the lack of competitive practice with left-handed athletes; left-handed athletes’ widespread use of simple attacks without transference with high speed. The number of left-handed fencers from 2002-2003 to 2016-2017 sports seasons increased by 48 athletes. Today, they are between 12 and 42% in the first 50 world rankings. The largest number is in teams of Russia, Italy, the USA, and China. Of the 146 left-handed athletes, 45% (66 people) represent Russia, Italy, the USA, and China in the top ten. Cases of incorrect orientation of fencers’ training were identified. This determines the relevance of accounting for functional asymmetry at the initial stages of training. Conclusions. The features of duel between the fencers with dominant right and left extremities, tendency to increase the number of left-handed fencers in the international sports arena from 2002 to 2017 were determined. Fencers’ individual profiles of asymmetry were studied, cases of incorrect orientation of athletes’ training were identified.
Необходимые уточнения относительно джугафилии
Authors: Ханин Гирш Ицыкович
Published: June 2020

Цитирование: Ханин Г.И. (2020) Необходимые уточнения относительно джугафилии  // Мир России. Т. 29. № 3. С. 177–193. DOI: 10.17323/1811-038X-2020-29-3-177-193

Книга Д.Б. Орешкина «Джугафилия и советский статистический эпос» содержит резкую критику появившихся в последние 15–20 лет в российском обществе и среди части ее научной элиты ностальгии по советскому прошлому. Автор противопоставляет ей разоблачение многих сторон советской действительности, опираясь на фальсификацию советскими властями статистики для демонстрации достижений социализма. Особенно впечатляют подсчеты огромных жертв населения в советский период и другие свидетельства материальных и духовных лишений населения в этот период. В настоящей рецензии содержатся уточнения ряда приводимых в книге оценок по различным периодам дореволюционной, советской и постсоветской экономической истории России. Автор книги идеализирует экономические достижения дореволюционной России, при этом игнорируя усилия В.И. Ленина по упорядочению денежной системы весной 1918 г. и преувеличивая экономические успехи НЭП. Для этого периода,  как и последующих, автор не учел значительных ошибок в оценке основных фондов, преуменьшение их стоимости, что приводило к преувеличению их динамики и рентабельности экономики. Показывается, что постсоветские экономические и политические реформы наряду с достижениями в области политических прав человека и в сфере бытовых услуг привели к стагнации и последующему экономическому кризису, вызванному сокращением основных фондов, и огромной социальной дифференциации. Приведены расчеты совокупной факторной производительности для дореволюционной экономики, периода НЭП, советского периода и постсоветского периода на основе макроэкономических альтернативных оценок, проведенных автором рецензии.
Shamanism in a Post-socialist City
Authors: Шмыт Збигниев
Published: June 2020

Citation: Szmyt Z. (2020) Shamanism in a Post-socialist City. Mir Rossii, vol. 29, no 3, pp. 51–65. DOI: 10.17323/1811-038X-2020-29-3-51-65

This article focuses on shamanic placemaking and the struggles for public space in the Siberian city of Ulan-Ude. Special attention is given to the indigenization of the city, which is a result of the mass immigration of Buryats from rural areas and the decay of the Soviet urbanization model. The article investigates how contemporary shamanism is involved in the decolonization of the urban space, new temporalization, and indigenous placemaking. Instead of dealing with traditional shamanist mediation between spirits and people, the emphasis is on mediation between the idea of ethnicity and the urban space.
Политические основания государственной поддержки некоммерческого сектора: анализ распределения президентских грантов в России
Authors: Бедерсон Всеволод Дмитриевич , Семенов Андрей Владимирович
Published: June 2020

Цитирование: Бедерсон В.Д., Семенов А.В. (2020) Политические основания государственной поддержки некоммерческого сектора: анализ распределения президентских грантов в России // Мир России. Т. 29. № 3. С. 96–120. DOI: 10.17323/1811-038X-2020-29-3-96-120

В статье анализируется проблема заинтересованности авторитарного режима в покупке лояльности организаций гражданского общества. Традиционно автократии и гражданские ассоциации рассматриваются как антагонисты, однако современные исследования и политическая практика демонстрируют более сложную и гибкую взаимосвязь. Современные автократии не только контролируют активность гражданских ассоциаций, но и используют их для укрепления собственной устойчивости. Мы используем данные о распределении президентских грантов среди некоммерческих организаций с правозащитной тематикой в 2017–2018 гг. в России и открытые данные о включенности представителей этих НКО в общественные и политические структуры: консультативно-совещательные органы, Общероссийский народный фронт и парламентские партии. Анализ показывает, что существуют политические основания для финансового поощрения некоммерческих организаций. Опираясь на количественный анализ объемов выделенной финансовой помощи, мы демонстрируем, что наравне с опытом значимыми предикторами для получения большей суммы гранта является участие представителя НКО в деятельности Общероссийского народного фронта, а также в выборах от партий системной оппозиции.  Участие в деятельности партии власти, напротив, не является фактором, гарантирующим получение большей суммы гранта.
Addgene Covid-19,Back To Work Training v1
Authors: Kamens Joanne , The Nonprofit Plasmid Repository Addgene
Published: June 2020

Disclaimer: The SOP presented here has been designed by the Addgene nonprofit plasmid repository and is being shared outside of Addgene for informational purposes only. If you choose to reuse or repurpose this SOP in another location, please note that you do so at your own risk; you should ensure that any local guidance is also adhered to. None of the authors, contributors, administrators, or anyone else associated with protocols.io, can be held responsible for your use of the information contained in or linked to from these web pages.
Neurocognitive Evidence for Different Problem-Solving Processes between Engineering and Liberal Arts Students
Authors: Liu Yu-Cheng , Liang Chaoyun
Published: June 2020

Differences exist between engineering and liberal arts students because of their educational backgrounds. Therefore, they solve problems differently. This study examined the brain activation of these two groups of students when they responded to 12 questions of verbal, numerical, or spatial intelligence. A total of 25 engineering and 25 liberal arts students in Taiwan participated in the experiment. The results were as follows. (i) During verbal intelligence tasks, differences between the two groups were observed in the information flows of verbal message comprehension and contextual familiarity detection in the problem-identifying phase, whereas no significant differences were found in the resolution-reaching phase. (ii) During numerical intelligence tasks, differences between the two groups were observed in the information flows of mental calculation and message comprehensionin the problem-identifying phase and those of verbal perception and analogical reasoning in the resolution-reaching phase. (iii) During spatial intelligence tasks, differences between the two groups were observed in the information flows of spatial relation integration and spatial context memory retrieval in the problem-identifying phase and those ofspatial attentionand contextual relation integration in the resolution-reaching phase.
Teacher’s Narration of Teaching Critical Literacy: It’s a KEY for Raising Students’ Awareness in Iran
Authors: Tohidian Iman , Khorsandi Taskoh Ali
Published: June 2020

To be literate, students need to able to think critically and read between the lines to find the implicit meanings and ideologies. To help Iranian English language learners learn writing as a social action and not independent of social (in)justices and (in)equalities, we included critical literacy in a writing course at the University of [for anonymity]. We intend to illuminate teacher’s narration about raising students’ awareness towards (mal)practices, (in)justices, and (in)equalities of the society in their writings.To do so, all 52 undergraduate 3rd-year-EFL learners of English Literature and Translation participated in our writing class. The teacher was also an associate professor (50 years old) with critical literacy as his main area of research. Students were required to write essays as mid-term and final exams. The teacher’s reflection on the course in general and on the EFL learners’ reflective essays highlighted that teaching writing through critical literacy helped students realize that writing is a process dependent on different social and political issues.Students’ growth in critical consciousness through their writing reminds teaching practitioners, policy-makers, and teacher educators to provide innovation in their classrooms to empower language learners with teaching methodologies contrary to what they are accustomed to during their learning.
Development of a model for the wet steam separation in the steam space of PGV-1000M steam generator
Authors: Gorbunov V.A. , Lonshakov N.A. , Mechtaeva M.N.
Published: June 2020

The issue of reducing steam humidity at the output of steam generator is relevant. The value of humidity directly affects the safety and efficiency of power plants. The optimization of steam generator design will enable to enhance its separation properties and reduce steam humidity. Creating a numerical model of wet steam separation process in a full-scale steam generator and its verification will allow proceeding to optimize the steam generator design and evaluate the model effectiveness. This article presents a preliminary study of the wet steam separation process in the steam space of PGV-1000M steam generator. To study the wet steam separation process in the steam space of PGV-1000M steam generator, a numerical model was developed in the ANSYS Fluent finite element analysis system. The following assumptions were made: the surface of the evaporation mirror is flat, drops have a spherical shape, they do not affect the movement of steam, they do not interact with each other, and there is no decay of the droplets. A three-dimensional model of the steam space of PGV-1000M steam generator which allows considering the processes of wet steam separation has been obtained. The analysis of the results has shown that the nature of the processes occurring in the model corresponds to theoretical calculations and operational data. The developed model has been verified and can be used to optimize the steam generator design. Further numerical studies of the developed model will enable to determine the most optimal design of the steam generator which provides the highest efficiency of steam separation. Moreover, it is possible and promising to study the effect of the evaporation mirror surface on the steam humidity in the steam generator. Decreasing the steam humidity at the steam generator output at existing and projected power plants will provide significant savings in funds spent on repairing the steam turbine blade apparatus, and will lead to an increase in the thermal efficiency of the plant.