bluuebunny/crossref_metadata_2025 huggingface dataset:
Analytical Study on Bond Slip Behaviour of CSRC Slabs
Authors: S. Abhinand R. , D. Harith Suraj
Published: September 2023

A composite slab with profiled steel deck and concrete are mainly used in steel framed building systems. The two major functions of profiled steel deck are it serves as a permanent formwork during the casting of concrete and after the concrete has dried and hardened, serve as a tensile reinforcement. The horizontal slippage is because of to the longitudinal shear stress developed when ultimate shear force is reached. In order to reduce the slippage, the steel deck should be properly connected to concrete and also to each other by mechanical shear connectors like stud shear connector, perfobond ribs and their combinations. Here a parametric study on different shear connector configurations including bolts and perfobond shear connector are done. The composite slab is modelled and analysed under push test in ANSYS to find out the effective shear connector configuration and also to find the effectiveness of shear connectors.
Key Performance Indicators for Life Cycle Performance Measurement of PPPs in Sustainable Port Development Projects
Authors: Mathew Anna , Nayar Seema K , Sathyapal Santhosh
Published: September 2023

Public-Private Partnerships (PPP) are contractual relationships between the public and private sectors in infrastructure development and have been applied widely in the global construction market. The Port sector is one among the top sectors in which PPP arrangement is used widely. As a crucial part of the multimodal transport, ports are of great economic and strategic importance for the country. Therefore, the performance evaluation of Port projects implemented as PPPs should be given due importance. This project aims to develop a set of Key Performance Indicators (KPIs) for the life cycle performance measurement of PPPs in sustainable port development projects. 47 KPIs were identified from literature and opinions of practitioners in the field were investigated through a questionnaire survey. The significance and correlations between elements in the model were established using Principal Component Analysis, resulting in a refined version of the KPI set. New KPIs obtained from the survey were also incorporated into the final set. Based on the results, a conceptual model of KPIs and associated stakeholders was developed, as a phase wise relevance matrix.
Evolution of Arbitration Law in India
Authors: P. Senthil Kumar , Thomas Anu V.
Published: September 2023

The construction industry is considered to be one of the most dispute-prone industries in the world. Disputes of any kind need to be solved through alternate dispute resolution methods to avoid delay in the completion of the projects and thereby reduce financial losses. Arbitration is an alternative dispute resolution mechanism that has been in use since ancient times worldwide. In India, various laws related to arbitration were formulated prior to British rule and also post-independence. In this paper, an attempt has been made to compare the different Arbitration Acts existing in India to study their effectiveness in dispute resolution.
The effects of the informal economy on the relationship between financial development and economic growth
Authors: Khayati Anis , Terzi Chokri
Published: September 2023

The relationship between economic growth and the development of financial systems has been analyzed from different perspectives for a long time. This paper addresses the effects of the informal economy on the relationship between financial development and economic growth, using a panel data covering 20 countries during the period 1993–2020. The results show that financial development, as measured by the IMF’s Financial Development Index, is positively associated with economic growth (the coefficient α1 related to financial development fd is positive and statistically significant at 5%). The results also show that large sizes of the informal economy moderate the influence of this association (α1 remains positive and statistically significant at 1%, while the coefficient α2 related to the interaction between financial development and informal economy, fd and ie, is negative and statistically significant at 1%). In effect, financial development has the greatest impact on economic growth whenever there is control over the informal economy’s size. Inversely, a favorable ground for the informal economy limits the positive association between financial development and economic growth. However, the results show the absence of a causality relationship between financial development and economic growth (W-bar = 1.0015 and Z-bar = 0.0048; p-value = 0.9980). The informal economy plays no role in making this type of link significant (W-bar = 0.9761 and Z-bar = -0.0756; p-value = 0.9520).
Kutsal Roma Cermen İmparatoru Şarlken’in Evrensel Monarşi Politikası
Authors: YILDIZ Yusuf
Published: September 2023

Kutsal Roma Cermen İmparatoru Şarlken, imparator seçildikten sonra Habsburgların ana to-paklarına ilaveten, İspanya kralı dedesi Ferdinand’ın topraklarını da miras olarak devralarak o zamanki deyimle “güneşin batmadığı bir imparatorluğa” sahip olmuştur. Böylece Orta Çağ’dan beri tartışılan ve birçok Avrupalı hükümdarı cezbeden “evrensel monarşi” kurma düşüncesi yeniden gündeme gelmiştir. Temeli Roma geleneği ve Hristiyan teolojisine dayanan ve Şarl-ken’in baş şansölyesi Mercurino Gattinara’da tarafından şiddetle savunulan bu düşünceye göre İmparator, önce Avrupa’daki din düşmanlarını ortadan kaldırarak din birliğini sağlayacak ve kıtayı hakimiyeti altına alacaktı. Daha sonra da Katolik Hristiyanlığın dışarıdaki baş düşmanla-rı olan Türkleri yenerek dünyada tek bir din ve hükümdarın hâkim olduğu evrensel yönetim sistemi kurulacaktı. Bu çalışmada, Şarklen’in bir evrensel monarşi kurmak için sahip olduğu elverişli ve elverişsiz şartlar ortaya konulacaktır. Son olarak, İmparatorun bu siyaseti sahip ol-duğu imkanlar dahilinde gerçekte ne derece uygulamaya çalıştığı gösterilmeye çalışılacaktır.
Ankara’da Ahi Şerafeddin Evkafı (XVI-XIX. Yüzyıllar)
Authors: KÖÇ Ahmet
Published: September 2023

Öz: İslam toplumlarının en önemli yardımlaşma kurumu olan vakıflar, Osmanlı döneminde uyguladıkları politikalarıyla ön plana çıkmışlardır. Çeşitli alanlarda uygulanan vakıf politikaları kimi zaman padişahlar veya onun hizmetinde çalışanlar tarafından kimi zaman da reaya sınıfı mensupları tarafından oluşturulmuştur. Çalışmada ele alınan Ahi Şerafeddin Evkafı, XIV. Yüzyılda Ankara’da kurulduğu bilinmekle birlikte, Osmanlı devrinde daha da genişleyerek; cami, zaviye, türbe, imaret ve diğer yapılarla bir külliye niteliğine kavuşturulmuştur. Zikredilen külliyenin gelir kaynakları geniş alanlara yayılan arazilerden ve ticari yapılardan elde edilmiştir.

Ahi Şerafeddin’in kişiliği hakkında literatürde bilgi bulunmakla birlikte onun ailesi ve vakıfları hakkındaki bilgi daha sınırlıdır. Osmanlı devrinde aile mensupları arasında seyyitlerin bulunması onları daha seçkin hale getirmiştir. Ahi Şerafeddin Evkafı’nda yönetimi elinde bulunduran aile mensuplarının hem ahi neslinden gelmeleri hem de seyyit soyundan olmaları onları, toplumun önde gelen hatırı sayılır kişileri yapmıştır.

Ankara eşrafından olan bu çok yönlü aileden bazı kişiler ilmiyede, bürokraside, askeriyede görev yaparken bazı kişiler de ticaret ve tarım sektörlerinde faaliyet yürütmüşlerdir. Bu çok yönlü aile mensuplarının İstanbul ve Ankara’da ne tür görevlerde bulunduklarını, vakıflarının faaliyetlerini, Ankara Şer‘iye sicilleri, tahrir defterleri ve arşiv belgelerinden hareketle ele alacaktır.
An Investigation of an Important Armenian Church Architecture in terms of Urban Identity: Digor Khtzkong Monastery
Authors: ÖZKAYNAK YOLCU Merve
Published: September 2023

Cultural heritage enables us to have information about past civilizations that form the identity of the built environment in a residential area. While cultural heritage structures reflect the material properties and techniques of the period they belong to, the architectural styles they adopted, and the level of civilization, they express the societies they belong to and the way of life of the societies, world view, management style and religious structure. For this reason, the sustainability of cultural heritage is important for the preservation of the local identity of societies and the continuity of cultural values. However, historical buildings such as mosques, churches, monasteries, chapels, synagogues, madrasas, inns, baths and castles, which reflect the identity of different regions, were built in masonry. Masonry structures, on the other hand, are not resistant to natural disasters such as earthquakes.

In this context, it is aimed to examine the monastery, which consists of five churches from the Armenian churches in the Eastern Anatolia Region of Turkey. This monastery is Khıdskonk Monastery, which consists of the Churches of St. Karapet, Virgin Mary (Surp Asdvadzdzin), St. Stefanos, St. Krikor and St. Sarkis. The churches, which differ in terms of culture and architecture, are important in terms of having the first church plan typologies. The problem of the study is that the remains of four of the five churches that were built in the same region and that were recently built, and that only one church is partially preserved. Based on this problem, it is aimed to document and archive these churches, which are important for the Kars region, and to examine their plan typologies. In this context, the relationship between earthquake damage and typologies was investigated and evaluations were made for the churches surveyed in the sample area. As a result, by emphasizing the importance of cities for their identities, suggestions were made for the protection of cultural heritage.
A look at the migration of Albanians from Kosovo to Albania in 1934
Authors: R. GASHİ Sami
Published: September 2023

The paper provides detailed data on the Albanian families who moved from Kosovo to Albania during 1934, relying on the archival data of the Central Archive of Albania. Based on the researched documents, we have provided data on the migration of Albanians from Kosovo, their settlement in Albania, the families that moved to Albania, the number of members specifying them by name, surname, origin, the reason for the migration, the place where they settled, etc.
Deciphering Gender Dynamics and Discrimination in Turkish Marriage through Speech Patterns
Authors: KARA Gökçen
Published: September 2023

This research embarks on a complicated journey to uncover the gender within the institution of Turkish marriage, focusing on the linguistic manifestations of discrimination against women. Through critical analysis of conversations between married individuals, the study seeks to illuminate how marital dialogs not only share everyday experiences, but also uphold, challenge, or change deeply rooted social norms and prejudices. Participants were tasked with delineating perceived gender roles within marital boundaries. Their responses, juxtaposed with the recorded conversations of 10 married couples — all from the researcher’s immediate circle — offer a multi-layered insight into the implicit biases and potential microaggressions inherent in everyday interactions. This methodological choice was anchored in the belief that genuine dialogs from familiar contexts would reveal both overt and covert forms of gender discrimination.

By analyzing these recordings, the study aims to identify overarching characteristics and differences in the conversational styles of men and women. Preliminary findings suggest that linguistic markers may unintentionally perpetuate traditional gender roles and biases, underscoring subtle but persistent mechanisms of discrimination against women in Turkish society. Through this research, we aim to shed light on the deeper linguistic structures at play and their implications for broader social change.
Establishment of district-led production of WHO-recommended Alcohol-Based Hand Rub (ABHR) during the COVID-19 pandemic: a model for improving access to ABHR during health emergencies
Authors: Tusabe Fred , Lamorde Mohammed , Medley Alexandra , Kesande Maureen , Lozier Matthew J. , Yapswale Sauda , Ociti Francis , Isabirye Herbert , Nuwamanya Elly , Nanyondo Judith , Boore Amy , Vosburgh Waverly , Kasule Juliet N. , Pratt Caroline , Berendes David
Published: September 2023

In response to the COVID-19 pandemic, we established and sustained local production of Alcohol-Based Hand Rub (ABHR) at a district scale for healthcare facilities and community, public locations in four districts in Uganda. District officials provided space and staff for production units. The project renovated space for production, trained staff on ABHR production, and transported ABHR to key locations. The production officer conducted internal ABHR quality assessments while trained district health inspectors conducted external quality assessments prior to distribution. Information, education, and communication materials accompanied ABHR distribution. Onsite ABHR consumption was monitored by site staff using stock cards. On average, it took 11 days (range: 8–14) and 5,760 USD (range: 4,400–7,710) to setup a production unit. From March to December 2021, 21,600 L of quality-controlled ABHR were produced for 111 healthcare facilities and community locations at an average cost of 4.30 USD/L (range: 3.50–5.76). All ABHR passed both internal and external quality control (average ethanol concentration of 80%, range: 78–81%). This case study demonstrated that establishing centralized, local production of quality-controlled, affordable ABHR at a district-wide scale is feasible and strengthens the ability of healthcare workers and community locations to access and use ABHR during infectious disease outbreaks in low-resource countries.
Perspectives of sustainable development vs. law enforcement on damage, pollution and environmental conservation management in Indonesia
Authors: Pardede Marulak , Situmorang Mosgan , Aristeus Syprianus , Rumadan Ismail , Lumban Toruan Henry Donald , Diogenes  , Djamilus  , Nugrahani Ellen Lutya Putri
Published: September 2023

This study uses a normative juridical method based on literature studies to obtain secondary data sourced from primary, secondary, and tertiary legal materials. Specifications of research are analytically descriptive. The data analysis method used is qualitative juridical. The results of the study show that overall government policies on environmentally friendly management have not been able to overcome the conflicts that often arise between the goals of environmental preservation and the goals of economic development. As a solution to overcome these obstacles, it is necessary to enforce criminal law, in addition to imposing material punishments (requiring proof) for crimes which are genetic crimes, it is also necessary to apply formal offenses (no need for proof) for crimes which are specific crimes. The process of enforcing environmental law from the aspect of criminal law will be more successful if it is handled by agencies that technically and institutionally deal with environmental issues. In addition, the concept of sustainable development must be implemented in the legal system for environmental management. In the future, it is necessary to develop coordination between law enforcement officials who are assembled.
Development in the Inhibition of Dengue Proteases as Drug Targets
Authors: Akram Muhammad , Hameed Shehryar , Hassan Abbas , Khan Khalid Mohammed
Published: September 2023

Background:

Viral infections continue to increase morbidity and mortality severely. The flavivirus genus has fifty different species, including the dengue, Zika, and West Nile viruses that can infect 40% of individuals globally, who reside in at least a hundred different countries. Dengue, one of the oldest and most dangerous human infections, was initially documented by the Chinese Medical Encyclopedia in the Jin period. It was referred to as "water poison," connected to flying insects, i.e., Aedes aegypti and Ae-des albopictus. DENV causes some medical expressions like dengue hemorrhagic fever, acute febrile illness, and dengue shock syndrome.

Objective:

According to the World Health Organization report of 2012, 2500 million people are in danger of contracting dengue fever worldwide. According to a recent study, 96 million of the 390 million dengue infections yearly show some clinical or subclinical se-verity. There is no antiviral drug or vaccine to treat this severe infection. It can be con-trolled by getting enough rest, drinking plenty of water, and using painkillers. The first dengue vaccine created by Sanofi, called Dengvaxia, was previously approved by the US-FDA in 2019. All four serotypes of the DENV1-4 have shown re-infection in vaccine recipients. However, the usage of Dengvaxia has been constrained by its adverse effects.

Conclusion:

Different classes of compounds have been reported against DENV, such as nitrogen-containing heterocycles (i.e., imidazole, pyridine, triazoles quinazolines, quinoline, and indole), oxygen-containing heterocycles (i.e., coumarins), and some are mixed heterocyclic compounds of S, N (thiazole, benzothiazine, and thiazolidinediones), and N, O (i.e., oxadiazole). There have been reports of computationally designed compounds to impede the molecular functions of specific structural and non-structural proteins as potential therapeutic targets. This review summarized the current progress in developing dengue protease inhibitors.
Statins and Portal Hypertension: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Jamialahmadi Tannaz , Reiner Zeljko , Riahi Maryam Matbou , Emami Seyed Ahmad , Tayarani-Najaran Zahra , Salehabadi Sepideh , Kesharwani Prashant , Al-Rasadi Khalid , Sahebkar Amirhossein
Published: September 2023

Background:

Statins are primarily used to decrease elevated LDL-cholesterol
and thus prevent atherosclerotic cardiovascular disease. Portal hypertension is one of the
most important complications of chronic liver disease. Several studies indicated that
statins might be beneficial for portal hypertension as well but there is still no clear answer
whether this is true or not.

Methods:

A literature search of the major databases was performed to find eligible randomized
controlled trials (RCTs) analyzing the effect of statins on portal hypertension
from inception to February 5th, 2021. Six RCTs with 442 patients who received statin or
statin plus carvedilol were finally included. Meta-analysis was performed using the Comprehensive
Meta-Analysis V2 software.

Results:

Reduction of portal hypertension after statin treatment was not significant
(WMD: -0.494, 95% CI: -1.239, 0.252, p=0.194; I2:0%). The reduction of portal hypertension
was robust in the leave-one-out sensitivity analysis.

Conclusion:

Treatment with statins did not decrease significantly portal hypertension.
In silico Strategy: A Promising Implement in the Development of
Multitarget Drugs against Neurodegenerative Diseases
Authors: Banjare Purusottam , Wamanrao Matore Balaji , Murmu Anjali , Kumar Vikash , Singh Jagadish , Roy Partha Pratim
Published: September 2023

Multi-target drug development (MTDD) is the demand of the recent era, especially in
the case of multi-factorial conditions such as cancer, depression, neurodegenerative diseases (NDs),
etc. The MTDD approaches have many advantages; avoidance of drug-drug interactions, predictable
pharmacokinetic profile, and less drug resistance. The wet lab practice in MTDD is very
challenging for the researchers, and the chances of late-stage failure are obvious. Identification of
an appropriate target (Target fishing) is another challenging task in the development of multi-target
drugs. The in silico tools will be one of the promising tools in the MTDD for the NDs. Therefore
the outlook of the review comprises a short description of NDs, target associated with different
NDs, in silico studies so far done for MTDD for various NDs. The main thrust of this review is to
explore the present and future aspects of in silico tools used in MTDD for different NDs in combating
the challenge of drug development and the application of various in silico tools to solve the
problem of target fishing.
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
Authors: Farghaly Thoraya A. , Pashameah Rami A. , Bayazeed Abrar , Al-Soliemy Amerah M. , Alsaedi Amani M. R. , Harras Marwa F.
Published: September 2023

Background:

Since CDKs have been demonstrated to be overexpressed in a wide spectrum
of human malignancies, their inhibition has been cited as an effective technique for anticancer
drug development.

Methods:

In this context, new bis-oxindole/spiro-triazole-oxindole anti-breast cancer drugs with
potential CDK4 inhibitory effects were produced in this work. The novel series of bis-oxindole/spirotriazole-
oxindole were synthesized from the reaction of bis-oxindole with the aniline derivatives then
followed by 1,3-dipolar cycloaddition of hydrazonoyl chloride.

Results:

The structure of these bis-oxindole/spiro-triazole-oxindole series was proven based on their
spectral analyses. Most bis-oxindole and bis-spiro-triazole-oxindole compounds effectively inhibited
the growth of MCF-7 (IC50 = 2.81-17.61 μM) and MDA-MB-231 (IC50 = 3.23-7.98 μM) breast cancer
cell lines with low inhibitory activity against normal WI-38 cells. While the reference doxorubicin
showed IC50 values of 7.43 μM against MCF-7 and 5.71 μM against the MDA-MB-231 cell line.
Additionally, compounds 3b, 3c, 6b, and 6d revealed significant anti-CDK4 activity (IC50 = 0.157-
0.618 μM) compared to palbociclib (IC50 = 0.071 μM). Subsequent mechanistic investigations
demonstrated that 3c was able to trigger tumor cell death through the induction of apoptosis. Moreover,
it stimulated cancer cell cycle arrest in the G1 phase. Furthermore, western blotting disclosed
that the 3c-induced cell cycle arrest may be mediated through p21 upregulation.

Conclusion:

According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment
targeting CDK4.
Evaluation of the Protective Effects of Vitamins E and D on Oxidative
Stress and Inflammation Caused by Tamoxifen in the Renal Tissue of
Female Wistar Rats
Authors: Khalid Mohammad Zardasht , Mohagheghi Sina , Pourkabir Roghayyeh Abbasali , Bahmani Mahdi , Nourian Alireza , Shafiee Gholamreza
Published: September 2023

Background:

Tamoxifen is an effective drug for breast cancer treatment and its side effects
are the production of reactive oxygen species and kidney damage. As antioxidants, vitamins E and D
may help decrease kidney dysfunction.

Objectives:

In the present study, the protective effects of vitamins E and D on renal toxicity caused by
tamoxifen in female Wistar rats were investigated.

Materials and Methods:

Twenty-five adult female rats weighing 180-200 were randomly divided into
five groups with 5 rats. Group C, T, TE, TD, and TED were treated with olive oil, tamoxifen, tamoxifen
+ vitamin E, tamoxifen +vitamin D, and tamoxifen + both vitamins for four weeks. ELISA Kits
measured the oxidant and antioxidant tests and TNF-α in kidney tissue. The spectrophotometric method
measured urea, uric acid, and creatinine in serum and urine.

Results:

Tamoxifen significantly decreased the weight of rats, GPx, CAT, SOD levels and increased
TNF-α, urinary creatinine level and, serum uric acid, urea levels (P < 0.05). But, treatment
with vitamin D and simultaneous administration of vitamins led to a significant decrease in the level
of (TNF-α) compared to the tamoxifen group (p < 0.01). Also, the histopathology results showed
that the simultaneous administration of vitamins has significantly resolved the damage caused by
the use of tamoxifen.

Conclusion:

The present study's findings showed that using vitamins E and D prevents kidney damage
through antioxidant and anti-inflammatory effects. In addition, using vitamins E and D probably
showed stronger synergistic effects against kidney damage.
Mesenchymal Stem Cell-Derived Exosomes Mitigate Acute Murine Liver
Injury via Ets-1 and Heme Oxygenase-1 Up-regulation
Authors: Kao Ying-Hsien , Chang Chih-Yang , Lin Yu-Chun , Chen Po-Han , Lee Po-Huang , Chang Huoy-Rou , Chang Wen-Yu , Chang Yo-Chen , Wun Shen-Fa , Sun Cheuk-Kwan
Published: September 2023

Background:

Mesenchymal stem cells (MSCs)-derived exosomes have been previously
demonstrated to promote tissue regeneration in various animal disease models. This study investigated
the protective effect of exosome treatment in carbon tetrachloride (CCl4)-induced acute liver
injury and delineated possible underlying mechanism

Methods:

Exosomes collected from conditioned media of previously characterized human umbilical
cord-derived MSCs were intravenously administered into male CD-1 mice with CCl4-induced
acute liver injury. Biochemical, histological and molecular parameters were used to evaluate the
severity of liver injury. A rat hepatocyte cell line, Clone-9, was used to validate the molecular
changes by exosome treatment.

Results:

Exosome treatment significantly suppressed plasma levels of AST, ALT, and pro-inflammatory
cytokines, including IL-6 and TNF-α, in the mice with CCl4-induced acute liver injury. Histological
morphometry revealed a significant reduction in the necropoptic area in the injured livers
following exosome therapy. Consistently, western blot analysis indicated marked elevations in hepatic
expression of PCNA, c-Met, Ets-1, and HO-1 proteins after exosome treatment. Besides, the
phosphorylation level of signaling mediator JNK was significantly increased, and that of p38 was
restored by exosome therapy. Immunohistochemistry double staining confirmed nuclear Ets-1 expression
and cytoplasmic localization of c-Met and HO-1 proteins. In vitro studies demonstrated
that exosome treatment increased the proliferation of Clone-9 hepatocytes and protected them from
CCl4-induced cytotoxicity. Kinase inhibition experiment indicated that the exosome-driven hepatoprotection
might be mediated through the JNK pathway.

Conclusion:

Exosome therapy activates the JNK signaling activation pathway as well as up-regulates
Ets-1 and HO-1 expression, thereby protecting hepatocytes against hepatotoxin-induced cell
death.
Targeting PPARγ/ NF-κB Signaling Pathway by Britannin, a Sesquiterpene Lactone
from Inula aucheriana DC., in Gastric Cancer
Authors: Abdolmohammadi Mohammad Hossein , Roozbehani Maryam , Hamzeloo-Moghadam Maryam , Heidari Fatemeh , Fallahian Faranak
Published: September 2023

Background:

Gastric cancer is one of the most common and deadliest malignancies in the world. Therefore,
there is an urgent need to develop new and effective agents to reduce mortality. The plants of genus Inula have gained
the attention of researchers worldwide as a rich source of potent medicinal compounds.

Objective:

This study explores the anti-cancer activity of Britannin, a sesquiterpene lactone isolated from Inula
aucheriana DC., and its molecular mechanism in gastric cancer cells, AGS and MKN45

Methods:

Cytotoxicity was evaluated through the MTT assay following 24 h, 48 h, and 72 h treatment with different
concentrations of Britannin. Apoptosis rate and caspase-3 activity were measured 24 h after treatment by Britannin. .
Western blotting was performed to determine the expression of the NF-κB, IκBα, and PPARγ proteins. Moreover,
quantitative RT-PCR was applied to measure the expression of NF-κB target genes.

Results:

We showed that Britannin induced cell growth inhibition and apoptosis in gastric cancer cells. Britannin
caused an elevation in mRNA and protein levels of PPARγ. The involvement of PPARγ was more confirmed using
GW9662, a PPARγ inhibitor. Suppression of NF-κB was demonstrated by western blot analysis. Down-regulation of
MMP-9, TWIST-1, COX-2, and Bcl-2 and up-regulation of Bax were also observed in gastric cancer cells.

Conclusion:

These results imply that activation of the PPARγ signaling pathway through suppression of NF-κB underlies
the anti-cancer properties of Britannin in gastric cancer. Therefore, Britannin could be considered as a promising
anti-cancer candidate for further evaluation.
Intracerebroventricular Injection of MHY1485 Blocked the Beneficial
Effect of Adiponectin on Aversive Memory in the STZ Model of Dementia
Authors: Rashtiani Samira , Goudarzi Iran , Jafari Adele , Rohampour Kambiz
Published: September 2023

Background:

The most prominent adipokine, adiponectin (APN), has an adverse relationship
with the malfunction of adipose tissue. Obesity causes a decrease in plasma APN levels,
which eventually results in insulin resistance and diabetes. In this study, we assessed how the effects
of APN on memory are influenced by the insulin receptor substrate-1 (IRS-1) and the mammalian
target of rapamycin (mTOR) pathways.

Methods:

Streptozotocin (STZ) 3 mg/kg intracerebroventricular injections on days 1 and 3 following
cannulation were used to create an animal model of Alzheimer's disease. The acquisition phase
was preceded by injections of MHY and adiponectin. For the passive avoidance task, the stepthrough
latency and total duration in the dark compartment were recorded and evaluated, and the
preference index was calculated for the novel object identification test. IRS-1 protein expression in
the hippocampus was assessed by western blotting.

Results:

STZ reduced the step-through latency (STL), which rose significantly (P≤0.001) in the
APN+STZ group. The memory-improving effects of APN were reversed when MHY was administered
first (P≤0.001). The STZ and APN+STZ+MHY groups both had a substantial decline in the
preference index (P≤0.01). Compared to the control group, the STZ group's expression of the IRS-
1 protein was dramatically reduced (P≤0.0001). In contrast to the APN+STZ group, the MHYtreated
group likewise showed decreased IRS-1 protein expression (P≤0.0001), but APN+STZ was
able to enhance IRS-1 expression rate (P≤0.0001).

Conclusion:

In a rat model of AD, we found that adiponectin improved aversive and cognitive
memory, which is at least partially mediated by the mTOR signaling cascade.
Overview of the Balanced Suspension Patents
Authors: Liu Hongbo , Li Cong , Yang Xiaodong
Published: September 2023

Background:

The suspension has the role of transmitting and carrying the forces and moments between the wheels and the frame and controlling the wheel runout, thus providing the car with good comfort and operational stability.

Objective:

Through the analysis of the current situation of suspension research, we summarize the research line and specific technical solutions of suspension, and finally, we provide an outlook on the future development direction of suspension, which in turn can provide some reference value for readers.

Methods:

The existing suspensions are classified into passive suspensions, semi-active suspensions, and active suspensions, and their improvement methods are described to compare the advantages and disadvantages of different improvement methods.

Results:

By comparing the results of suspension studies, semi-active suspension can effectively improve the smoothness and handling stability of the vehicle. Semi-active suspension has the advantages of low energy consumption, simple control, lower cost, easy implementation, and high reliability, while the effect of vibration control can be close to active suspension to some extent and far better than passive suspension.

Conclusion:

This paper introduces passive suspension, semi-active suspension, and active suspension in three categories and describes the working principle, functions, problem-solving advantages, and shortcomings of the three suspensions, respectively. Semi-active suspension is more suitable for the future development trend of suspension.
An Approach for Microencapsulation of Melaleuca alternifolia Oil using Different Techniques and its Application
Authors: Shelar Samidha , Pradhan Subhalaxmi , Madankar Chandu S.
Published: September 2023

Tea tree oil (TTO) is a widely known essential oil extracted from Melaleuca
alternifolia leaves naturally having antimicrobial and antibacterial activities. Tea tree oil
is widely used in a variety of industries, including agrochemicals, pharmaceuticals, medicine,
food, textiles, as well as cosmetic and hygiene products. To overcome the limitation
of tea tree oil being highly volatile and reactive, microencapsulation has become one
of the preferred methods to retain and control these compounds. This review explores the
different techniques for encapsulating tea tree oil. Along with a comprehensive overview
of the most recent research and applications of microencapsulated tea tree oil, microencapsulation
techniques and the available technologies are also discussed.
Issuer Credit Rating Performance Report Using Sentiment Analysis
Authors: Setyaji Prabu , Ponnusamy Raja Rajeswari
Published: September 2023

Indonesian Credit Rating Agency (CRA) is currently on its way to becoming
the early mover of digital transformation. CRA controls macroeconomics and has a
significant impact on many industries across the world. However, there are always
those that can exploit it through asymmetric information and human interaction. A
solution to reduce human interaction and enhancement is to build Natural Language
Processing (NLP) sentiment analysis models and then display the results using an
interactive dashboard story. Objectives are created for the aim of the project to be able
to conduct a feasibility study, develop a model based on a press release dataset,
conduct model evaluation, and display the results on an interactive dashboard. The
research aims to utilise press release documents with NLP sentiment analysis to
produce prescriptive analysis with interactive visualisation as the final output. Press
release files are processed by using several Machine Learning (ML) algorithms such as
Support Vector Machine (SVM), Multinomial Naive Bayes (MultinomialNB), Logistic
Regression (LR), and Multi-Layer Perceptron Artificial Neural Network (MLP-Ann).
This research will be carried out under Dynamic Systems Development (DSDM) and
Knowledge Discovery Database (KDD). This will allow the researchers to achieve all
objectives, permit models to perform very well, and let the output get displayed on a
dashboard as a storyboard.
Recommendations for Implementing an IoT-Based Inventory Tracking and Monitoring System
Authors: Rana Muhammad Ehsan , Shanmugam Kamalanathan , Yu Hang Chan
Published: September 2023

Inventory management is vital in the industry because it allows
manufacturers and wholesalers to efficiently store and manage information in the
warehouse. Warehouse management provides the facility to control functions such as
storing newly shipped products in available locations and tracking inventory
information and product distribution for shipping. These complex processes in the
warehouse management system require manufacturers and wholesalers to ensure that
the warehouse operation is running smoothly and efficiently. The use of the Internet of
Things (IoT) for automating industrial and household processes has been increasing
rapidly in the last few years. This research focuses on IoT for tracking and monitoring
inventory, providing an automated and efficient system for manufacturers and
wholesalers. A comprehensive discussion has been conducted on IoT application layers
and recommended sensors for inventory tracking and monitoring systems. This
research also emphasizes applying IoT in inventory, logistics, and warehousing
operations. Researchers have proposed an IoT-based system specifically designed to
cater to the shortcomings of the existing inventory management systems.
Digital Divide in Primary Schools
Authors: Soundrapandian Veerakumar
Published: September 2023

The gap in the use of the Internet and computers in society is classified as
the level-two digital divide. Research papers from 61 popular journals published
between 2005 to 2018 were examined to carry out a Systematic Literature Review
(SLR). In addition, renowned organisations’ research publications from 2010 to 2018
were used. The adoption of technology, the type of use, the frequency of use, and the
effectiveness of use were the main areas of level-two Digital Divide research. This use
is further affected by the accessibility determinants of Affordability, Gender, Age,
Education Level, Race, and Digital Skills. None of the research used the accessibility
determinants as a moderator between availability and use.
Intrusion Detection System for the Internet of Medical Things (IoMT)
Authors: N. Alasaad Ameer A. , Abd Rahman Nor Azlina , Yusof Yusnita
Published: September 2023

In this paper, the authors proposed the design of an Intrusion Detection
System (IDS) that can be used in the healthcare sector to increase cybersecurity. This
sector is facing high cyber threats. Similar IDS systems will be reviewed in the
following pages, followed by the justifications of why the authors decided to design the
IDS to be Signature-based. The experimental results showed that the developed IDS
could successfully capture the network traffic, record the logs and show an informative
alarm screen with a few other options within the dashboard to assist the user in
handling the situation and assure the hospital network security.
Machine Learning for Browser Privacy
Authors: Tan Kelvin , Logeswaran Rajasvaran
Published: September 2023

Online privacy is an Internet user’s control of how much personal
information is shared with a third party. Unfortunately, some third parties, such as data
brokers, collect user data without permission to resell the data to other parties. Browser
tracking allows each Internet user to be uniquely identified, and in-depth user profiles
are built. Browser fingerprinting is one of the most effective methods of browser
tracking. It uniquely identifies each user through their devices’ configuration, even for
users using the same device models. Using Virtual Private Networks, the Tor browser
and specific browser extensions as a countermeasure against browser fingerprinting are
not widespread, so it often results in a compromised user experience. Researchers have
proposed various classification machine learning approaches to improve browser
privacy; some focus on recognising and blocking advertisements and website scripts
that track users. In contrast, others identify potential vulnerabilities in browser security
configurations. There is a need for more research in machine learning, especially
natural language processing, to enhance browser privacy.
ARP Spoofing in Launching Man-in-the-Middle Attack
Authors: Qi Huan Soon , Selvarajah Vinesha
Published: September 2023

Man-in-the-Middle (MITM) attack is a typical eavesdropping cyberattack.
The attacker can launch a MITM attack whenever the attacker and victims are on the
same network. Here is a scenario: A MITM attacker connects to Subway’s Wi-Fi and
waits for the victim to connect to the Subway Wi-Fi. Eventually, Victim A walks in
and connects to Subway’s Wi-Fi. Once Victim A gets connected and is on the same
network as the attacker, the attacker can launch an attack to intercept the network
traffic of Victim A. Therefore, everyone on the same network connection with the
attacker can be the target of a MITM attack. In this paper, the MITM attack will be
introduced. The attacker can spy on the victim, steal sensitive credentials, disrupt
communications, or even corrupt the data through the said attack. To discover how the
MITM attack works, this paper explains it based on the ARP Spoofing attack, which
exploits the ARP protocol to send out forged ARP responses. ARP Spoofing attack is
one of the MITM attacks. This paper emphasises the MITM attack phases, different
types of MITM attacks, ARP Spoofing attacks, and how ARP works. The
demonstration of steps for launching an ARP Spoofing attack and the tools involved,
like Nmap, Arpspoof, and Wireshark, are also included.
IoT-Based Medical Ecosystem
Authors: Wan Jing Wong , Abdul Rahman Nor Azlina , Mago Vistro Daniel
Published: September 2023

The Internet of Things (IoT) is an evolving technology in the emerging
digital transformation domain. The healthcare system is also growing, using IoT to
improve human life and save more lives. With the assistance of IoT technology,
physicians can easily monitor patients’ health conditions in real-time. A cardiac
pacemaker is a medical device connected to the IoT environment to improve the
efficiency of healthcare. However, low-quality IoT design will bring disadvantages,
such as cyber-attacks. Every process of building IoT medical devices should evaluate
the product before launching it to the market. Manufacturers or hospitals should
organise their critical infrastructure orderly to protect confidential data. The data
should achieve the confidentiality, integrity, and availability of the CIA triad, which is
the foundation of information security. This paper aims to study the vulnerabilities of
IoT medical devices, the methods of possible attacks from hackers, and organisational
and operational security to address cyber security in the healthcare industry. Moreover,
it proposes a framework for the IoT medical ecosystem between the patient and the
hospital to improve the existing IoT medical ecosystem.
Recent Trends of Nanobiosensor in Agriculture
Authors: Borah Dhitri , Kumar Goswami Ravi , Kumar Shrivastav Avanish , Giri Priti , Kumar Neelesh , Singh Tejveer
Published: September 2023

Sustainable agriculture has the potential to benefit greatly from
nanobiosensors. Nanomaterials are crucial components of numerous biotic and abiotic
remediation systems and have a huge impact on the mobility, fate and toxicity of soil
contaminants in agriculture. It is believed that nanobiosensor have a revolutionary
impact on the field of agriculture by focusing research and development toward the
goals of achieving sustainable agriculture. Nanobiosensors have significant benefits
such as improved recognition sensitivity or specificity, and retain immense promise for
the application of nanobiosensor in various areas such as food quality and bioprocess
control, agriculture, biodefense and medical applications. Nanobiosensors application
in the agricultural area has significantly improved productivity. The economic and
cutting-edge nanobiosensors have been emphasised in this book chapter to address the
difficulties in the main agricultural industry and emphasize the significance of
nanobiosensor to detect insecticides, herbicides, fertilizers and diseases for increasing
crop yield.
Homogeneous Explosions
Authors: Fabbricino Massimiliano , Andreozzi Roberto , Clarizia Laura , Cesaro Alessandra , Policastro Grazia , di Giovanni Concetta
Published: September 2023

Gas and vapour explosions can be classified as homogeneous and heterogeneous.
Homogeneous explosions are characterized by an autoignition temperature and a delay time to
ignition.
The Health Impact Assessment within Environmental Impact Assessment Studies
Authors: Fabbricino Massimiliano , Andreozzi Roberto , Clarizia Laura , Cesaro Alessandra , Policastro Grazia , di Giovanni Concetta
Published: September 2023

Sustainability and sustainable development play a central role in addressing
strategies and policies at the national and international level. Both these concepts have been
largely discussed and different approaches have been proposed over time to promote their
practical implementation, including the preventive one. In this context, Environmental Impact
Assessment (EIA) has been built and developed to prevent or mitigate the negative impacts of
a variety of anthropogenic activities on several environmental factors, including human health.
Among the activities undergoing EIA, the building and operation of various chemical industrial
plants may represent relevant scenarios to assess their wider health implications from a
preventive perspective. The evaluation of these impacts on human health has been recently
approached following a formally identified procedure, namely the Health Impact Assessment
(HIA).
This chapter aims at providing an overview on HIA, with particular reference to its integration
within the EIA procedures: the legislative framework is thus figured out and the main features
of HIA are discussed to point out its strengths and weaknesses as a decision supporting tool
during the assessment of the environmental impacts of projects.
Systematic Literature Review of UTAUT Model to Understand Adopter's Perception of Digital Mobile App Applications in the Indonesian Coal Mining Industry
Authors:   School of Business and Management, Bandung Institute of Technology, Bandung, Indonesia, Sujati Wiwin , Yudoko Gatot , Okdinawati Liane
Published: September 2023

Purpose This study investigates coal mining firms' technology use during epidemics and their strategies. It applies the UTAUT to the coal mining sector, focusing on five main aspects. Design/Methodology/Approach This study employs a systematic literature review (SLR) to analyze data from 13 selected papers on mobile app usage as digital technology. Data from 2014 to 2022 were gathered using the Scopus database, revealing insights into UTAUT-related research trends in the mining industry. Findings Reviewing the chosen papers reveals a strong link between tech adoption and leadership in coal mining. Empowered leadership notably drives technology adoption, positively impacting knowledge processes among followers. Research Limitations/Implications It recognizes that the systematic literature review offers valuable insights but findings could be constrained by available relevant papers. Future research might delve into more tech adoption and leadership aspects in coal mining to boost understanding. Originality/Value This research fills a gap by deeply examining technology adoption with UTAUT in coal mining. Given limited existing research, this study contributes insights and knowledge about digital tech in this field. Moreover, exploring leadership empowerment as a unique form adds originality and value to the research.
Current Account Sustainability of South Africa with Regime Shifts
Authors:   North-West University, South Africa, Stungwa Senela
Published: September 2023

Purpose This study investigates the sustainability of current account with possible regime shifts in South Africa. Design/methodology/approach The study makes use of an annual data spanning from 1980 to 2021, the data is collected from International monetary fund. To ensure the order of integration of variables, the study used Fourier LM unit root test and Minimum LM unit root test. The study uses maki cointegration test with multiple structural breaks to examine the long run relationship between the variables in the presence of structural breaks. Findings Maki cointegration test confirmed a long run relationship between exports and imports of goods and services. The results indicate that the current account sustainability of South Africa is weakly. Research limitations/implications This study did not consider the effect of nonlinearities in the modelling processes. Another drawback of this study is that it did not use frequency analysis such as wavelet /Fourier transform since the current account can be affected by volatilities in the domestic and global markets. Therefore, for future studies it will be better if they overcome the limitations of this study. Originality/value This study focuses specifically on the issue of current account sustainability, taking into consideration the possible consequences of structural changes brought about by South Africa's prior economic crises. In addition, this study recommends the devaluation of currency for South Africa to ensure that the exports always exceed imports or the improvement in the current account deficit.