bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations Among the Big Five Personality Traits, Maladaptive Cognitions, and Internet Addiction Across Three Time Measurements in 3 Months During the COVID-19 Pandemic
Authors: Tian Yu , Zhao Yanli , Lv Fengling , Qin Ningbo , Chen Peipei
Published: May 2021

The present study examined the longitudinal association among the Big Five personality traits, maladaptive cognitions, and Internet addiction during the COVID-19 pandemic. A total of 481 Chinese university students (247 men; mean age = 20.31 years) were surveyed three times (interval of 1 month) by using the Chinese version of the Big Five Personality Traits Scale, Maladaptive Cognitions Scale, and Internet Addiction Scale. The results of a cross-lagged panel analysis highlighted that (i) extraversion, agreeableness, conscientiousness, and openness were negatively associated with maladaptive cognitions and Internet addiction, whereas neuroticism was found to be positively associated with maladaptive cognitions and Internet addiction across time; (ii) associations among the Big Five personality traits, maladaptive cognitions, and Internet addiction were dynamic and bidirectional; and (iii) maladaptive cognitions played mediating roles in extraversion, agreeableness, conscientiousness, openness, and Internet addiction across time. The Big Five personality traits, maladaptive cognitions, and Internet addiction predicted each other across time, and maladaptive cognitions were likely to be the key mediating factor in the associations between the Big Five personality traits and Internet addiction, which supported and expanded the Davis’ cognitive–behavioral model.
Knowledge, Attitudes, and Practices of Urban Residents Toward COVID-19 in Shaanxi During the Post-lockdown Period
Authors: Xu Na , Zhang Yongai , Zhang Xiaona , Zhang Guangwei , Guo Zikai , Zhao Nan , Li Fei
Published: May 2021

Background: The coronavirus disease 2019 (COVID-19) pandemic in China is essentially under control. Under global scrutiny, China has started reviving the social, cultural, and working lives of its inhabitants. However, localized outbreaks of COVID-19 are occurring, indicating that the country still needs to follow disease prevention and control measures. Previous studies have assessed the knowledge, attitudes, and behaviors of the general public in China regarding COVID-19 during the pandemic. However, little is known about knowledge, attitudes, and practices (KAP) of Chinese residents regarding COVID-19 after periods of lockdown. Therefore, this study was conducted to identify the KAP and other factors among the residents of Shaanxi Province during the post-lockdown period.

Methods: A cross-sectional, network questionnaire survey was conducted in Shaanxi Province from October 1–30, 2020. A total of 1,175 urban residents were interviewed via Wen Juan Xing, an online questionnaire tool. A self-developed online KAP COVID-19 questionnaire was developed in this study. The questionnaire consisted of four parts: general information, knowledge, attitude, and practice. Descriptive statistics and binomial logistic regression analysis were used in the statistical analysis.

Results: The majority of the participants were knowledgeable about COVID-19. They had optimistic attitudes and behaved appropriately toward COVID-19. Education was an associated factor for the knowledge of residents and the knowledge of COVID-19 was high among people with high academic qualifications. Attitudes were more positive in residents who lived with elderly people, women, and children. The score of practice was higher in residents with positive attitudes and high academic qualifications. There was a positive correlation between age and practice.

Conclusion: We found that the KAP of residents in Shaanxi was at a relatively high level during the post-lockdown period. Although the lockdown was lifted, the epidemic is not over. Thus, it is necessary to develop targeted health education programs for residents with different demographic characteristics in Shaanxi.
Molecular Epidemiology and Drug Resistant Mechanism of Carbapenem-Resistant Klebsiella pneumoniae in Elderly Patients With Lower Respiratory Tract Infection
Authors: Shao Chunhong , Wang Wei , Liu Shuang , Zhang Zhijun , Jiang Meijie , Zhang Fusen
Published: May 2021

Infection by carbapenem-resistant Klebsiella pneumoniae (CRKp) hampers the treatment of elderly patients with lower respiratory tract infection (LRTI); however, relevant data with respect to the characteristics of CRKp in elderly patients with LRTIs are limited. In the present study, K. pneumoniae isolated from elderly patients with LRTIs was collected and identified by VITEK-MS. VITEK 2 compact was used for drug sensitivity test to screen CRKps, and broth dilution method was used for drug sensitivity of tigecycline and colistin. The resistance genes, virulence genes, and serotypes of CRKps were detected via polymerase chain reaction. The homology of CRKps was analyzed via PFGE and MLST. Moreover, plasmid conjugation experiment was carried out to determine the transferability of carbapenem resistance. PCR-based replicon typing (PBRT) and S1 nuclease-PFGE were conducted for plasmid profiling. From January 2019 to August 2019, 258 elderly patients with LRTIs caused by K. pneumoniae were observed; of these, 31 (12.02%) infections were caused by CRKp strains. Majority of the patients were admitted to the intensive care unit and neurosurgery wards. Intracranial hemorrhage and pneumonia were the most common underlying diseases. Furthermore, 29 patients infected by CRKp had been exposed to various antimicrobial drugs before the positive culture. All isolates exhibited high resistance to β-lactam antibiotics. The predominant carbapenem resistance gene was blaKPC−2, and CRKps carrying blaKPC−2 were all ST11 type. Two blaNDM−5 carrying isolates were assigned to ST307 and ST1562, respectively. Conjugative assays revealed that plasmids harboring blaNDM−5 gene were self-transmissible. Plasmid analysis suggested that two blaNDM−5 were located on a ~45 kb IncX3 type plasmid. The high incidence of CRKp in elderly patients with LRTIs indicates the urgent need for further surveillance and strict infection control measures.
Exploring the Development of the Sponge City Program (SCP): The Case of Gui'an New District, Southwest China
Authors: Qi Yunfei , Chan Faith Ka Shun , O'Donnell Emily C. , Feng Meili , Sang Yanfang , Thorne Colin R. , Griffiths James , Liu Lingyun , Liu Sitong , Zhang Chunqian , Li Lei , Thadani Dimple
Published: May 2021

Rapid urbanization has sharply increased the pressure of urban water issues (e.g., urban flooding and water pollution) in the Chinese megacities during last three decades. Sustainable urban water management approaches, such as Nature Based Solutions (NBS) and Low Impact Developments (LIDs), have successfully delivered long-term benefits to cities in Europe and North America. Similarly, the Chinese Sponge City Program (SCP) initiated in 2013 and experimented in 30 pilot Chinese cities. This paper reviewed the first stage of the SCP from 2015 to 2020 by using observation, Semi-Structured Interview (SSI) and Focus Group Approach (FGA) in context of Gui'an New Distinct, SW China to investigate the SCP progress and issues: (1). whether it is effectively solving urban water issues; (2). if there are any major challenges and barriers in the SCP practice. The findings of this case study provide potential solutions for improving the SCP and sustainable urban water management and possibly transform to other Sponge Cities in China.
Monochromatic X-Ray Imagers of the Sun Based on the Bragg Crystal Optics
Authors: Reva Anton A. , Kuzin Sergey V. , Kirichenko Alexey S. , Ulyanov Artem S. , Loboda Ivan P. , Bogachev Sergey A.
Published: May 2021

Investigations of solar activity require information about plasma in a wide range of temperatures. Generally, researchers require observations from telescopes producing monochromatic images of coronal plasma with cool, warm, and hot temperatures. Until now, monochromatic telescopic imaging has been made only in the Mg XII 8.42 Å line with the Mg XII spectroheliograph on board CORONAS-I, CORONAS-F, and CORONAS-PHOTON satellites. The Mg XII spectroheliograph used Bragg crystal optics. Its design is based on two main principles: (1) to select the working wavelength and the crystal in such a way that reflection occurs at small incident angles; (2) to use the aperture of the mirror as a spectral filter. We believe that these design principles can be applied to other spectral lines. In this article, we will review the design of the Mg XII spectroheliograph and present our thoughts on how to apply these principles to the Si XIV 6.18 Å and Si XIII 6.65 Å lines. A combination of the monochromatic Mg XII 8.42 Å, Si XIV 6.18 Å, and Si XIII 6.65 Å images will help us to study the dynamics of the hot plasma in the solar corona.
Polyvinylpyrrolidone (PVP) and Na-Alginate Addition Enhances the Survival and Agronomic Performances of a Liquid Inoculant of Bradyrhizobium japonicum for Soybean (Glycine max (L.) Merr.)
Authors: Maitra Pulak , Al-Rashid Jubair , Mandal Dipa , Azam Md. Shofiul , Rasul Noorain Munim
Published: May 2021

Nontoxic polymers PVP and Na-alginate may provide a favorable environment for the survival of bacteria. Therefore, PVP and Na-alginate were added to a growth medium to develop a liquid inoculant of Bradyrhizobium japonicum strain. The strain was identified by 16S rDNA sequencing. The addition of PVP (1.8%) and Na-alginate (0.2%) in the medium promoted a better survival (1.93 × 109 cells mL−1) of B. japonicum strain compared to the control (3.50 × 102 cells mL−1) after 6 months of storage. The combination of PVP and Na-alginate ensured 1.53 × 107 cells mL−1 up to 12 months of storage under ambient temperature (28 ± 2 °C), whereas PVP (1.8%) or Na-alginate (0.2%) alone produced similar cell counts only up to 8 months and 6 months, respectively. Consecutive field experiments proved the efficacy of the liquid inoculant on nodulation and yield of soybean. The combination of PVP and Na-alginate-based inoculation of B. japonicum strain significantly increased the nodule number per plant, number of pods per plant, number of seeds per pod, seed yield, and yield per hectare (p ≤ 0.05). Thus, the combination of PVP- and Na-alginate-based inoculation of B. japonicum has great potential to popularize the organic cultivation of soybean.
Agronomic Biofortification of Significant Cereal Crops with Selenium—A Review
Authors: Galić Lucija , Vinković Tomislav , Ravnjak Boris , Lončarić Zdenko
Published: May 2021

Selenium (Se) is an important micronutrient which is essential for most living organisms and occurs in both organic and inorganic forms in the water system, soils, biomass, and the atmosphere. In addition to being essential for humans and animals, Se is beneficial for plants and is mostly involved in antioxidant activity/response, as well as a growth promoter. Se deficiency in the diet is a global problem, and Se levels in soils generally reflect its presence in food and, thus, availability to humans. Se participates in the antioxidant response mechanisms of the organism, heavy-metal detoxification, and regulation of the reproductive and immune system, as well as ensures the proper function of the thyroid gland. Plants are the main dietary source of Se for humans. Biofortification is a key strategy to increase Se in edible parts of plants. Agronomic biofortification provides an effective route to increase Se content in edible crop products via application of Se-enriched fertilizers to soil or by foliar application. The most common cereals in the human diet are wheat, rice, maize, and barley, making them the most suitable targets for agronomic biofortification. This review focuses on summarizing the most efficient form and method of Se application via agronomic biofortification corroborated by a meta-analysis of the literature reports. In the assessed literature, foliar application showed better results compared to application in soil. The selenate form appears to be the more efficient form of Se for biofortification than selenite in the most common cereals in human diet: wheat, rice, maize, and barley.
Several Aspects of Application of Nanodiamonds as Reinforcements for Metal Matrix Composites
Authors: Popov Vladimir
Published: May 2021

After detonation synthesis, primary nanodiamond particles are around 4–6 nm in size. However, they join into agglomerates with larger parameters and weak bonds between particles. The introduction of agglomerates into a metal matrix can lead to the weakness of composites. This paper demonstrates the possibility of obtaining a non-agglomerated distribution of nanodiamonds inside a metal matrix. The fabrication method was based on mechanical alloying to create additional stresses and deformations by phase transformations during treatment in a planetary mill. According to the findings, the starting temperature of the reaction between the non-agglomerated nanodiamonds and aluminium matrix reduces to 450 °C. Furthermore, the paper shows that existing methods (annealing for the transformation of a diamond structure into graphitic material and cleaning from this graphitic material) cannot reduce the sizes of nanodiamonds in the agglomerated state. Agglomerated nanodiamonds transform into carbon onions (graphitic material) during annealing in a vacuum in the following way: the nanodiamonds located in the surface layers of the agglomerate are the first to undergo the complete transformation followed by the transformation of nanoparticles in its deeper layers. In the intermediate state, the agglomerate has a graphitic surface layer and a core from nanodiamonds: cleaning from graphite cannot reduce nanodiamond particle size.
Visual SLAM for Indoor Livestock and Farming Using a Small Drone with a Monocular Camera: A Feasibility Study
Authors: Krul Sander , Pantos Christos , Frangulea Mihai , Valente João
Published: May 2021

Real-time data collection and decision making with drones will play an important role in precision livestock and farming. Drones are already being used in precision agriculture. Nevertheless, this is not the case for indoor livestock and farming environments due to several challenges and constraints. These indoor environments are limited in physical space and there is the localization problem, due to GPS unavailability. Therefore, this work aims to give a step toward the usage of drones for indoor farming and livestock management. To investigate on the drone positioning in these workspaces, two visual simultaneous localization and mapping (VSLAM)—LSD-SLAM and ORB-SLAM—algorithms were compared using a monocular camera onboard a small drone. Several experiments were carried out in a greenhouse and a dairy farm barn with the absolute trajectory and the relative pose error being analyzed. It was found that the approach that suits best these workspaces is ORB-SLAM. This algorithm was tested by performing waypoint navigation and generating maps from the clustered areas. It was shown that aerial VSLAM could be achieved within these workspaces and that plant and cattle monitoring could benefit from using affordable and off-the-shelf drone technology.
Demand Response Alert Service Based on Appliance Modeling
Authors: Chatzigeorgiou Ioanna-M. , Diou Christos , Chatzidimitriou Kyriakos C. , Andreou Georgios T.
Published: May 2021

Demand response has been widely developed during recent years to increase efficiency and decrease the cost in the electric power sector by shifting energy use, smoothening the load curve, and thus ensuring benefits for all participating parties. This paper introduces a Demand Response Alert Service (DRAS) that can optimize the interaction between the energy industry parties and end users by sending the minimum number of relatable alerts to satisfy the transformation of the load curve. The service creates appliance models for certain deferrable appliances based on past-usage measurements and prioritizes households according to the probability of the use of their appliances. Several variations of the appliance model are examined with respect to the probabilistic association of appliance usage on different days. The service is evaluated for a peak-shaving scenario when either one or more appliances per household are involved. The results demonstrate a significant improvement compared to a random selection of end users, thus promising increased participation and engagement. Indicatively, in terms of the Area Under the Curve (AUC) index, the proposed method achieves, in all the studied scenarios, an improvement ranging between 41.33% and 64.64% compared to the baseline scenario. In terms of the F1 score index, the respective improvement reaches up to 221.05%.
Power Distribution Optimization Based on Demand Respond with Improved Multi-Objective Algorithm in Power System Planning
Authors: Abedinia Oveis , Bagheri Mehdi
Published: May 2021

In this article, a novel dynamic economic load dispatch with emission based on a multi-objective model (MODEED) considering demand side management (DSM) is presented. Moreover, the investigation and evaluation of impacts of DSM for the next day are considered. In other words, the aim of economical load dispatch is the suitable and optimized planning for all power units considering different linear and non-linear constrains for power system and generators. In this model, different constrains such as losses of transformation network, impacts of valve-point, ramp-up and ramp-down, the balance of production and demand, the prohibited areas, and the limitations of production are considered as an optimization problem. The proposed model is solved by a novel modified multi-objective artificial bee colony algorithm (MOABC). In order to analyze the effects of DSM on the supply side, the proposed MODEED is evaluated on different scenarios with or without DSM. Indeed, the proposed MOABC algorithm tries to find an optimal solution for the existence function by assistance of crowding distance and Pareto theory. Crowding distance is a suitable criterion to estimate Pareto solutions. The proposed model is carried out on a six-unit test system, and the obtained numerical analyses are compared with the obtained results of other optimization methods. The obtained results of simulations that have been provided in the last section demonstrate the higher efficiency of the proposed optimization algorithm based on Pareto criterion. The main benefits of this algorithm are its fast convergence and searching based on circle movement. In addition, it is obvious from the obtained results that the proposed MODEED with DSM can present benefits for all consumers and generation companies.
Process Water Recirculation during Hydrothermal Carbonization of Waste Biomass: Current Knowledge and Challenges
Authors: Picone Antonio , Volpe Maurizio , Messineo Antonio
Published: May 2021

Hydrothermal carbonization (HTC) is considered as an efficient and constantly expanding eco-friendly methodology for thermochemical processing of high moisture waste biomass into solid biofuels and valuable carbonaceous materials. However, during HTC, a considerable amount of organics, initially present in the feedstock, are found in the process water (PW). PW recirculation is attracting an increasing interest in the hydrothermal process field as it offers the potential to increase the carbon recovery yield while increasing hydrochar energy density. PW recirculation can be considered as a viable method for the valorization and reuse of the HTC aqueous phase, both by reducing the amount of additional water used for the process and maximizing energy recovery from the HTC liquid residual fraction. In this work, the effects of PW recirculation, for different starting waste biomasses, on the properties of hydrochars and liquid phase products are reviewed. The mechanism of production and evolution of hydrochar during recirculation steps are discussed, highlighting the possible pathways which could enhance energy and carbon recovery. Challenges of PW recirculation are presented and research opportunities proposed, showing how PW recirculation could increase the economic viability of the process while contributing in mitigating environmental impacts.
Evaluation of Physical and Chemical Parameters According to Energetic Willow (Salix viminalis L.) Cultivation
Authors: Roman Kamil , Roman Michał , Szadkowska Dominika , Szadkowski Jan , Grzegorzewska Emilia
Published: May 2021

The aim of this study was the investigation of the effect of growth conditions of energy willow (Salix viminalis L.) on its physical and chemical parameters towards lignocellulosic biofuels. This work is linked to the global trend of replacing fossil fuels (coal, oil, natural gas) with energy and renewable fuels. This energy transition is dictated by the reduction of the human-induced greenhouse effect (to the greatest extent by industrial development). Changing from traditional to renewable energy sources results in industry becoming less dependent on fuels whose sources are beginning to run out, and in energy processing being broken down into smaller sectors with greater flexibility to change and less susceptibility to failure. The use of lignocellulosic raw materials such as wood, straw, food industry waste, wood, and post-consumer products such as old furniture for energy purposes allows the use of substances which bind the greenhouse gas carbon dioxide in their cellular structure during growth. In order to optimise the costs of producing such energy and minimise its impact on the environment, these plants should be located as close as possible to the source of raw materials. One of the most important characteristics for the profitability of energy production from woody biomass is a high biomass yield. For this purpose, the raw material used for this study was energy willow (Salix viminalis L.) seedlings, which are often used for energy crops. Due to the moisture-loving nature of the substrate, the effect of the addition of the active substance prednisonum as a catalyst for water adsorption from the substrate was investigated. In order to determine the substances formed during the thermal decomposition of energy willow (Salix viminalis L.) wood, a pyrolysis process was carried out at 450 °C using pyrolysis gas chromatography mass spectrometry (PY/GC-MS).
Accuracy Improvement of Transformer Faults Diagnostic Based on DGA Data Using SVM-BA Classifier
Authors: Benmahamed Youcef , Kherif Omar , Teguar Madjid , Boubakeur Ahmed , Ghoneim Sherif S. M.
Published: May 2021

The main objective of the current work was to enhance the transformer fault diagnostic accuracy based on dissolved gas analysis (DGA) data with a proposed coupled system of support vector machine (SVM)-bat algorithm (BA) and Gaussian classifiers. Six electrical and thermal fault classes were categorized based on the IEC and IEEE standard rules. The concentration of five main combustible gases (hydrogen, methane, ethane, ethylene, and acetylene) was utilized as an input vector of the two classifiers. Two types of input vectors have been tested; the first input type considered the five gases in ppm, and the second input type considered the gases introduced in the percentage of the sum of the five gases. An extensive database of 481 had been used for training and testing phases (321 data samples for training and 160 data samples for testing). The SVM model conditioning parameter “λ” and penalty margin parameter “C” were adjusted through the bat algorithm to develop a maximum accuracy rate. The SVM-BA and Gaussian classifiers’ accuracy was evaluated and compared with several DGA techniques in the literature.
Effect of 3-Aminobenzoic Acid Ethyl Ester Methanesulfonate (MS-222) on Quality of Marine Cultured Turbot (Scophthalmus maximus) during Simulated Transport in Water
Authors: Cao Jie , Wang Qi , Mei Jun , Xie Jing
Published: May 2021

This study evaluated the effect of different concentrations (20, 40 and 60 mg/L) of 3-aminobenzoic acid ethyl ester methanesulfonate (MS-222) on the quality changes in turbot during simulated transport in water. The results showed that the ammonia nitrogen content in the transportation water of each sample increased significantly, and the dissolved oxygen level decreased. The dissolved oxygen content in MS-222-treated samples was higher than that of control group (CK) samples. For turbot flesh quality, simulated transport in water led to a decrease in moisture, fat and protein contents in all samples. The MS-222-treated turbot samples showed higher pH values, glycogen contents, springiness and chewiness values and lower lactic acid contents comparing with the CK samples during simulated transport in water. In addition, the fresh and bitter amino acids in the muscle of turbot increased in each treatment group compared to the non-transported fish at the end of the simulated transport. The results showed that MS-222 treatment could retard the turbot transport stress and improve the quality of turbot during simulated transport in water.
An Insight into the Growing Concerns of Styrene Monomer and Poly(Styrene) Fragment Migration into Food and Drink Simulants from Poly(Styrene) Packaging
Authors: Ajaj Asmaa , J’Bari Shayma , Ononogbo Anthonia , Buonocore Federico , Bear Joseph C. , Mayes Andrew G. , Morgan Huda
Published: May 2021

Poly(styrene) (PS) has been heavily utilised in disposable food packaging due to its insulating properties, optical translucency, and long-shelf life. Despite these desirable characteristics, (PS) poses toxicity concerns to human’s health through styrene monomer leaching into foodstuffs. Environmental and marine hazards are another growing concerns due to improper and/or absence of recycling strategies and facilities. This preliminary work aims to investigate the effect of temperature, food composition and contact times on the migration of the styrene monomer from poly(styrene) food contact materials into food simulants. Poly(styrene) cups showed a relatively low level of styrene migration with the highest being 0.110 µg/mL, whereas food containers showed a much higher level of styrene leaching with up to 6 µg/mL. This could be due to an increase in the hydrophobicity of the simulants’ characteristics from low to high fat content and the increase in the testing temperatures from 5 °C to 70 °C. ANOVA statistical analysis is used to compare the means of three or more groups of data, whereas t-test analysis is used to compare means of two groups. This was carried out on each individual sample to determine the significance of changing the temperature, simulant type, or both on the level of migration observed in the results. All significant values were tested at 95% confidence level p < 0.05, concluding that fat content and high temperatures were found to significantly increase the level of styrene migration. Nile Red staining method was used to demonstrate that particulate poly(styrene), as well as styrene monomer, migrated into tested food simulants from typical containers, which is becoming a cause for concern as evidence of microplastic ingestion increases.
Characterization and Discrimination of Commercial Portuguese Beers Based on Phenolic Composition and Antioxidant Capacity
Authors: Gouvinhas Irene , Breda Cristiana , Barros Ana Isabel
Published: May 2021

Beer has been highly appreciated due to its phenolic composition and antioxidant capacity conjugated with its low alcohol content. Although some studies exist regarding the phenolic composition and antioxidant capacities of beers, there are no studies related to the determination of these parameters in the most commonly consumed commercial beers in Portugal. The phenolic composition and antioxidant capacity of 23 Portuguese commercial beers of different styles and types were studied for the first time. The total phenolic content, ortho-diphenols, and flavonoids ranged between 0.15 ± 0.01 and 0.82 ± 0.07 g Gallic Acid (GA) L−1; 0.07 ± 0.02 and 1.80 ± 0.09 g GA L−1, and 0.02 ± 0.00 and 0.15 ± 0.02 g Catechin (CAT) L−1, respectively. An accurate quantitative phenolic analysis was also performed, and the compound identified with a higher amount was gallic acid, followed by syringic acid. Concerning flavonoids, gallo-catechin was the most abundant compound identified (from 21.44 ± 2.87 and 144.00 ± 10.93 μg mL−1). A significant correlation between ortho-diphenols and the antiradical capacity (ABTS and DPPH) was found, the latter being negatively correlated. Flavonoids content was also positively correlated with total phenols and antiradical capacity determined by the ABTS assay. These results evidence that phenolic composition is affected by several factors inherent to beers, namely ingredients, fermentation type, and brewing process.
Effects of Student Training in Social Skills and Emotional Intelligence on the Behaviour and Coexistence of Adolescents in the 21st Century
Authors: Vila Sara , Gilar-Corbí Raquel , Pozo-Rico Teresa
Published: May 2021

In recent decades, efforts have been made to achieve a positive coexistence among adolescents in secondary schools and create a healthy environment to prepare them to face the present-day challenges. Therefore, this study highlights the educational purpose of improving emotional management and social skills as well as decreasing antisocial and criminal behaviour among secondary education students through an educational training programme. Accordingly, to verify the effectiveness of the project, a quasi-experimental design with a pre-test/post-test structure and a control group was adopted. To achieve this, a total of 141 Spanish secondary school students participated in this study and were randomly assigned to one of two experimental conditions. The first (experimental) group (n = 55) participated in the training programme; correspondingly, the second group (control) (n = 57) followed the usual mentoring activities planned for the entire educational centre. Of the total number of participants, 52.7% of the sample were men and 47.3% were women. The mean age of the participants was 13.01 years old (SD = 0.935). The results showed improvements in the environment with adequate training and the correct application of a programme involving emotional intelligence (EI) among secondary education students. Furthermore, a decrease in conflicts and enhanced relations between the members of the educational community was evidenced. Finally, the practical implications for improving coexistence in secondary schools are discussed.
The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19
Authors: Iliadi Valeria , Konstantinidou Ina , Aftzoglou Konstantina , Iliadis Sergios , Konstantinidis Theocharis G. , Tsigalou Christina
Published: May 2021

Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. During an infection, neutrophils migrate from circulation to the infection site, contributing to killing pathogens. This mechanism is regulated by chemokines such as IL-8. Moreover, it was shown that neutrophils play an important role in thromboinflammation. Through a diverse repertoire of mechanisms, neutrophils, apart from directly killing pathogens, are able to activate the formation of thrombi. In COVID-19 patients, neutrophil activation promotes neutrophil extracellular trap (NET) formation, platelet aggregation, and cell damage. Furthermore, neutrophils participate in the pathogenesis of endothelitis. Overall, this review summarizes recent progress in research on the pathogenesis of COVID-19, highlighting the role of the prothrombotic action of neutrophils in NET formation.
Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion
Authors: Kotál Jan , Buša Michal , Urbanová Veronika , Řezáčová Pavlína , Chmelař Jindřich , Langhansová Helena , Sojka Daniel , Mareš Michael , Kotsyfakis Michail
Published: May 2021

The hard tick Ixodes ricinus is a vector of Lyme disease and tick-borne encephalitis. Host blood protein digestion, essential for tick development and reproduction, occurs in tick midgut digestive cells driven by cathepsin proteases. Little is known about the regulation of the digestive proteolytic machinery of I. ricinus. Here we characterize a novel cystatin-type protease inhibitor, mialostatin, from the I. ricinus midgut. Blood feeding rapidly induced mialostatin expression in the gut, which continued after tick detachment. Recombinant mialostatin inhibited a number of I. ricinus digestive cysteine cathepsins, with the greatest potency observed against cathepsin L isoforms, with which it co-localized in midgut digestive cells. The crystal structure of mialostatin was determined at 1.55 Å to explain its unique inhibitory specificity. Finally, mialostatin effectively blocked in vitro proteolysis of blood proteins by midgut cysteine cathepsins. Mialostatin is likely to be involved in the regulation of gut-associated proteolytic pathways, making midgut cystatins promising targets for tick control strategies.
Tandem Repeats in Bacillus: Unique Features and Taxonomic Distribution
Authors: Subirana Juan A. , Messeguer Xavier
Published: May 2021

Little is known about DNA tandem repeats across prokaryotes. We have recently described an enigmatic group of tandem repeats in bacterial genomes with a constant repeat size but variable sequence. These findings strongly suggest that tandem repeat size in some bacteria is under strong selective constraints. Here, we extend these studies and describe tandem repeats in a large set of Bacillus. Some species have very few repeats, while other species have a large number. Most tandem repeats have repeats with a constant size (either 52 or 20–21 nt), but a variable sequence. We characterize in detail these intriguing tandem repeats. Individual species have several families of tandem repeats with the same repeat length and different sequence. This result is in strong contrast with eukaryotes, where tandem repeats of many sizes are found in any species. We discuss the possibility that they are transcribed as small RNA molecules. They may also be involved in the stabilization of the nucleoid through interaction with proteins. We also show that the distribution of tandem repeats in different species has a taxonomic significance. The data we present for all tandem repeats and their families in these bacterial species will be useful for further genomic studies.
Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis
Authors: Timmerman Dennis M. , Remmers Tessa L. , Hillenius Sanne , Looijenga Leendert H. J.
Published: May 2021

The P53 pathway is the most important cellular pathway to maintain genomic and cellular integrity, both in embryonic and non-embryonic cells. Stress signals induce its activation, initiating autophagy or cell cycle arrest to enable DNA repair. The persistence of these signals causes either senescence or apoptosis. Over 50% of all solid tumors harbor mutations in TP53 that inactivate the pathway. The remaining cancers are suggested to harbor mutations in genes that regulate the P53 pathway such as its inhibitors Mouse Double Minute 2 and 4 (MDM2 and MDM4, respectively). Many reviews have already been dedicated to P53, MDM2, and MDM4, while this review additionally focuses on the other factors that can deregulate P53 signaling. We discuss that P14ARF (ARF) functions as a negative regulator of MDM2, explaining the frequent loss of ARF detected in cancers. The long non-coding RNA Antisense Non-coding RNA in the INK4 Locus (ANRIL) is encoded on the same locus as ARF, inhibiting ARF expression, thus contributing to the process of tumorigenesis. Mutations in tripartite motif (TRIM) proteins deregulate P53 signaling through their ubiquitin ligase activity. Several microRNAs (miRNAs) inactivate the P53 pathway through inhibition of translation. CCCTC-binding factor (CTCF) maintains an open chromatin structure at the TP53 locus, explaining its inactivation of CTCF during tumorigenesis. P21, a downstream effector of P53, has been found to be deregulated in different tumor types. This review provides a comprehensive overview of these factors that are known to deregulate the P53 pathway in both somatic and embryonic cells, as well as their malignant counterparts (i.e., somatic and germ cell tumors). It provides insights into which aspects still need to be unraveled to grasp their contribution to tumorigenesis, putatively leading to novel targets for effective cancer therapies.
Neuroprotection of the Perinatal Brain by Early Information of Cerebral Oxygenation and Perfusion Patterns
Authors: Costa Filipe Gonçalves , Hakimi Naser , Van Bel Frank
Published: May 2021

Abnormal patterns of cerebral perfusion/oxygenation are associated with neuronal damage. In preterm neonates, hypoxemia, hypo-/hypercapnia and lack of cerebral autoregulation are related to peri-intraventricular hemorrhages and white matter injury. Reperfusion damage after perinatal hypoxic ischemia in term neonates seems related with cerebral hyperoxygenation. Since biological tissue is transparent for near infrared (NIR) light, NIR-spectroscopy (NIRS) is a noninvasive bedside tool to monitor brain oxygenation and perfusion. This review focuses on early assessment and guiding abnormal cerebral oxygenation/perfusion patterns to possibly reduce brain injury. In term infants, early patterns of brain oxygenation helps to decide whether or not therapy (hypothermia) and add-on therapies should be considered. Further NIRS-related technical advances such as the use of (functional) NIRS allowing simultaneous estimation and integrating of heart rate, respiration rate and monitoring cerebral autoregulation will be discussed.
Risk Management of Bored Piling Construction on Sandy Soils with Real-Time Cost Control
Authors: Mata Pedro , Silva Paula F. , Pinho Fernando F. S.
Published: May 2021

In a global society, in which geotechnical projects are increasingly designed in a country other than the one where construction takes place, geotechnical risk management must be extended to cover infrastructure works, which are smaller than dams and tunnels, for example, since there is a significant impact on works budget imponderables. Therefore, a risk management methodology based on the likelihood of the occurrence of certain events and their economic consequences is proposed, which is applicable to bored piles (Kelly drilled) in coarse soils, easy to use, and simple to implement since the initial stage of construction. Of 12 case studies of construction works involving bored piles (Kelly drilled) carried out in Luanda (Angola), two selected examples involving the proposed risk methodology on sandy soil layers with interbedded clays are discussed. Subsequently, whether the overall foundation contract budget is affected by assessed risk is determined, and what influence it has on the budget in the light of mitigating factors and associated real costs. This method intended to encourage the adaptation of sustainable risk management in bored piles construction by the site project managers, involving risk analysis concurrently with budgetary review. Though the level of assessed technical risk may be acceptable, overall costs associated with the contract in question may not be acceptable.
Financial Contagion: A Tale of Three Bubbles
Authors: Burks Nathan , Fadahunsi Adetokunbo , Hibbert Ann Marie
Published: May 2021

The primary purpose of the study is to identify and measure the properties of asset bubbles, volatility clustering, and financial contagion during three recent financial market anomalies that originated in the U.S. and Chinese markets. In particular, we focus on the 2000 DotCom Bubble, the 2008 Housing Crisis, and the 2015 Chinese Bubble. We employ three main empirical methods; the LPPL model to identify asset bubbles, the DCC-GARCH model to measure volatility clustering, and the Diebold-Yilmaz volatility spillover index to measure the level of financial contagion. We provide robust evidence that during the DotCom bubble there was very limited spillover between the S&P 500, the Shanghai, and the Shenzhen Composite Indexes. However, there was significantly more spillover effects in the two more recent crises, i.e., the Housing crisis and the 2015 Chinese Bubble. Together, these results highlight the fact that as financial markets have become more globalized, there are greater levels of volatility transmission and correspondingly fewer potential benefits from international diversification.
Do Financial Professionals Process Information Better as a Group Than Non-Professionals?
Authors: Barron Orie , Enis Charles , Qu Hong
Published: May 2021

In this study, we study information processing by financial professionals benchmarked with non-professionals and how correlation among individual forecasts explains the group level forecast performance. In an experiment in which participants make price forecasts based on common financial information, we find that individual professionals are no better than individual non-professionals in forecasting, but professionals’ mean forecasts are superior. Our analysis suggests that financial professionals’ individual errors are less correlated as they process information from more diverse perspectives. This leads to superior mean forecasts because the uncorrelated individual errors cancel each other out in the aggregate. In contrast, non-professionals are similar in using salient information such as earnings or cash flow. As a result, their individual errors are highly correlated. Instead of cancelling each other out, the individual errors are enlarged in the aggregated mean forecasts. We are the first to show the difference in the comparisons of professionals and non-professionals at the group level versus at the individual level. Our paper contributes to the literature by documenting the evidence of diversity in information processing by financial professionals.
Bio-Based Crosslinked Polymers Synthesized from Functionalized Soybean Oil and Squalene by Thiol–Ene UV Curing
Authors: Grauzeliene Sigita , Valaityte Deimante , Motiekaityte Greta , Ostrauskaite Jolita
Published: May 2021

The development of polymers photopolymerized from renewable resources are extensively growing as fulfills green chemistry and green engineering principles. With the rapid growth of consumerism, research on innovative starting materials for the preparation of polymers may help to reduce the negative impact of petroleum-based plastic materials on the global ecosystem and on animal and human health. Therefore, bio-based crosslinked polymers have been synthesized from functionalized soybean oil and squalene by thiol–ene ultra-violet (UV) curing. First, thiol–ene UV curing of squalene was performed to introduce thiol functional groups. Then, hexathiolated squalene was used as a crosslinker in click UV curing of acrylated epoxidized soybean oil. Two photoinitiators, 2-hydroxy-2-methylpropiophenone and ethylphenyl (2,4,6-trimethylbenzoyl) phosphinate, were tested in different quantities. Rheological properties of the resins were monitored by real-time photorheometry. The characterization of obtained polymers was performed by differential scanning calorimetry, thermogravimetry, and Shore A hardness measurements. Polymers possessed higher storage modulus, thermal characteristics, Shore A hardness, and lower swelling value when ethylphenyl (2,4,6-trimethylbenzoyl) phosphinate was used as photoinitiator.
Nanoparticles of Bioactive Glass Enhance Biodentine Bioactivity on Dental Pulp Stem Cells
Authors: Corral Nunez Camila , Altamirano Gaete Diego , Maureira Miguel , Martin Javier , Covarrubias Cristian
Published: May 2021

This study aimed to investigate the cytotoxicity and bioactivity of a novel nanocomposite containing nanoparticles of bioactive glass (nBGs) on human dental pulp stem cells (hDPSCs). nBGs were synthesized by the sol–gel method. Biodentine (BD) nanocomposites (nBG/BD) were prepared with 2 and 5% wt of nBG content; unmodified BD and glass ionomer cement were used as references. Cell viability and attachment were evaluated after 3, 7 and 14 days. Odontogenic differentiation was assessed with alkaline phosphatase (ALP) activity after 7 and 14 days of exposure. Cells successfully adhered and proliferated on nBG/BD nanocomposites, cell viability of nanocomposites was comparable with unmodified BD and higher than GIC. nBG/BD nanocomposites were, particularly, more active to promote odontogenic differentiation, expressed as higher ALP activity of hDPSCs after 7 days of exposure, than neat BD or GIC. This novel nanocomposite biomaterial, nBG/BD, allowed hDPSC attachment and proliferation and increased the expression of ALP, upregulated in mineral-producing cells. These findings open opportunities to use nBG/BD in vital pulp therapies.
Generalization of Quantum Ostrowski-Type Integral Inequalities
Authors: Ali Muhammad Aamir , Ntouyas Sotiris K. , Tariboon Jessada
Published: May 2021

In this paper, we prove some new Ostrowski-type integral inequalities for q-differentiable bounded functions. It is also shown that the results presented in this paper are a generalization of know results in the literarure. Applications to special means are also discussed.
Discovery of Novel eEF2K Inhibitors Using HTS Fingerprint Generated from Predicted Profiling of Compound-Protein Interactions
Authors: Yoshimori Atsushi , Kawasaki Enzo , Murakami Ryuta , Kanai Chisato
Published: May 2021

Background: Eukaryotic elongation factor 2 kinase (eEF2K) regulates the elongation stage of protein synthesis by phosphorylating eEF2, a process related to various diseases including cancer and cardiovascular and neurodegenerative diseases. In this study, we describe the identification of novel eEF2K inhibitors using high-throughput screening fingerprints (HTSFP) generated from predicted profiling of compound-protein interactions (CPIs). Methods: We utilized computationally generated HTSFPs referred to as chemical genomics-based fingerprint (CGBFP). Generally, HTSFPs are generated from multiple biochemical or cell-based assay data. On the other hand, CGBFPs are generated from computational prediction of CPIs using the Chemical Genomics-Based Virtual Screening (CGBVS) method. Therefore, CGBFPs do not have missing information mainly caused by the absence of assay data. Results: Chemogenomics-Based Similarity Profiling (CGBSP) of the screening library (2.6 million compounds) yielded 27 compounds which were evaluated for in vitro eEF2K inhibitory activity. Three compounds with interesting results were identified. Compounds 2 (IC50 = 11.05 μM) and 4 (IC50 = 43.54 μM) are thieno[2,3-b]pyridine derivatives that have the same scaffolds with a known eEF2K inhibitor, while compound 13 (IC50 = 70.13 μM) was a new thiophene-2-amine-type eEF2K inhibitor. Conclusions: CGBSP supplied an efficient strategy in the identification of novel eEF2K inhibitors and provided useful scaffolds for optimization.