bluuebunny/crossref_metadata_2025 huggingface dataset:
Fraxin Prevents Knee Osteoarthritis through Inhibiting Chondrocyte Apoptosis in an Experimental Rat Osteoarthritis Model
Authors: Qian Zhigang , Ru Xuanliang , Liu Chun , Huang Xiaoqin , Sun Qicai
Published: October 2021

Background:

Current treatments of osteoarthritis are unsatisfied, a new approach towards
the treatment of osteoarthritis is urged considering the state at present.

Objectives:

The objective of this study is to investigate the effect of fraxin on knee OA in a rat model
and probe into the possible molecular mechanism.

Methods:

Primary Murine Chondrocytes were isolated and cell apoptosis analyses were performed.
Rat OA models were established using meniscectomy method and allocated into three groups.
Knee joint specimens were collected for qRT-PCR, western blotting and histological analysis. Statistical
analyses were processed by using a SPSS.

Results:

The apoptosis rate of fraxin group is significantly reduced compared with the OA group
or the control group. Fraxin remarkably down-regulated the expression of cleaved-Caspase-3 while
significantly up-regulated the expression of Bcl-2, both on mRNA and protein levels. Toluidine
blue stain results show relatively lighter articular cartilage damage compared with OA group.

Conclusion:

Fraxin prevents knee osteoarthritis by inhibiting chondrocyte apoptosis, which makes
it a potential candidate as an anti-OA drug for clinical use.
Functional Roles of Neuronal Nitric Oxide Synthase in Neurodegenerative Diseases and Mood Disorders
Authors: Poon Chi H. , Tsui Ka C. , Chau Sze C. , Chong Pit S. , Lui Sylvia W.Y. , Aquili Luca , Wong Kah H. , Lim Lee W.
Published: October 2021

Nitric oxide synthase (NOS) is well known for its involvement in the regulation of the
nervous, cardiovascular, and immune systems. Neuronal NOS (nNOS) is the most characterized
NOS among all the isoforms. It accounts for most of the production of nitric oxide (NO) in the nervous
system required for synaptic transmission and neuroplasticity. Previous studies have described
the localization of nNOS in specific brain regions of interest. There is substantial evidence
in the literature suggesting that nNOS signaling has significant involvement in several disease
pathologies. However, the association between brain nNOS expression profiles and disease remains
largely unknown. In this review, we attempt to delineate the contribution of nNOS signaling
in memory and mood disorders in order to achieve a better understanding of nNOS in disease modulation.
A Facile and Efficient Synthesis of bis(Imidazo[1,2-a]pyridin-3-yl)methane
and Vinyl Derivatives
Authors: Prasada Rao Daliparthi Eswara , Raju Medepalli David , Surendra Jasti , Babu Ala Vasu , Eswaraiah Poguri , Reddy Nallamaddi Ravi Kumar , Rajendiran Chinnapillai , Rao Mandava Venkata Basaveswara
Published: October 2021

An efficient synthetic route for the novel bis-imdizo[1,2-a]pyridine-3-yl)methane (2a-k)
derivatives have been developed using acetic acid and two drops of trifluoroacetic acid at 40-45oC,
resulting in 60-72% yields. An attempt to synthesize bis(Imidazo[1,2-a]pyridin-3-yl)methyl
chloride derivatives by the reaction between two moles of imidazo[1,2-a]pyridine, one mole of
chloroacetaldehyde in acetic acid, and two drops of trifluoroacetic acid was not successful, instead
underwent dehydrohalogenation to yield vinyl derivatives (4a-d).
Understanding Perceptions and Practices for Designing an Appropriate Community-Based Kangaroo Mother Care Implementation Package: Qualitative Exploratory Study
Authors: Ariff Shabina , Maznani Ikram , Bhura Maria , Memon Zahid , Arshad Tayyaba , Samejo Tariq Ahmed , Zaidi Shujaat , Umer Muhammad , Ahmed Imran , Habib Muhammad Atif , Soofi Sajid Bashir , Bhutta Zulfiqar A
Published: October 2021

Background

Low birth weight (LBW) is a common outcome of preterm birth, which increases the risk of an infant’s morbidity and mortality. Approximately 20 million infants are born with LBW globally per year. Since a significant number of births in Pakistan take place at home, it is important to focus on the use of kangaroo mother care (KMC), the practice of skin-to-skin contact, in communities to prevent neonatal mortality and morbidity.

Objective

We employed a formative research approach to understand the context of communities and facilities with regard to neonatal care and KMC practice. The broader aims were to inform the design and delivery of culturally appropriate platforms to introduce KMC in communities, and develop effective recruitment and retention strategies of KMC in rural areas of the Dadu district in the Sindh province of Pakistan.

Methods

We conducted focus group discussions, in-depth interviews, and key informant interviews with families of LBW babies, community members, health care providers, and hospital administrators to identify barriers, enablers, and a knowledge base for KMC interventions.

Results

Newborn care practices in communities were found to be suboptimal. The community was generally unaware of the KMC intervention for the care of LBW babies. However, facility health care providers, the community, and family members were willing to provide KMC to improve outcomes. We found significant support from the community members and health care providers for KMC practices. Mothers were also ready to provide intermittent KMC. The administrative staff at the hospitals accepted the introduction of KMC practices for LBW babies.

Conclusions

KMC as a method of treating LBW babies is widely accepted in the community. This formative research provides strategically valuable information that will be helpful for developing effective implementation strategies by identifying common community practices for LBW babies, along with identifying the barriers and enablers to KMC practice.
Gilliard et famille
Authors: Maggetti Daniel
Published: October 2021

Les nombreuses facettes des activités intellectuelles et littéraires de Henri Roorda ont laissé peu de traces manuscrites ou documentaires. Parmi les rares lettres de l’écrivain accessibles dans des archives, celles adressées à Edmond Gilliard et à la mère de ce dernier témoignent d’une proximité qui, toute discrète qu’elle est, n’en demeure pas moins exceptionnelle pour Roorda dans le contexte artistique lausannois. L’amitié que Gilliard manifestera à Roorda notamment dans son texte d’hommage posthume semble avoir été particulièrement importante pour la veuve de ce dernier, si l’on en juge par les quelques billets de sa main dont l’auteur du Pouvoir des Vaudois et son épouse sont les destinataires.

Keywords : Henri Roorda, Lili Roorda, correspondance, Edmond Gilliard, Ernest Ansermet, Marie Gilliard-Malherbe, Alice Gilliard, C. F. Ramuz, Cahiers vaudois.
Undernutrition dan Anestrus Pada Kambing Bligon Betina Umur 2-3 Tahun: Sebuah Studi Kasus
Authors: Muqit Kelviano , Widiyono Irkham , Yanuartono Yanuartono , Sarmin Sarmin , Murti Tridjoko Wisnu
Published: October 2021

Kajian kasus ini ditujukan untuk mengungkap fenomena klinis dan reproduktif yang dialami 5 ekor kambing Bligon betina umur 2-3 tahun yang dipelihara oleh petani di Yogyakarta. Menurut informasi dari pemilik, kambing mengalami kekurusan dan tidak pernah menunjukkan gejala berahi. Hewan sudah diobati dengan ivermectin secara berkala. Pada hewan tersebut selanjutnya dilakukan kajian manajemen pemeliharaan serta observasi dan pemeriksan klinis (pemeriksaan fisik, uii berahi, pemeriksaan sitologi vagina terhadap organ reproduksi)dalam kurun waktu sekitar 60 hari (akhir Juli- awal September 2019). Pada akhir periode observasi hewan diberi perlakuan gertak berahi dengan pemberian injeksi PGF2-alfa dua kali dengan selang 11 hari dan pemeriksaan USG. Hasil pemeriksaan klini hewan tidak bunting, tidak ditemukan adanya ekto dan endoparasit, tidak ditemukan adanya perubahan fisik, dan tanda-tanda penyakit infeksi. Selama masa pengamatan hewan mendapat pakan berupa jerami kangkung pada level sekitar 2% bobot badan, pertambahan bobot badan harian yang negatif atau rendah, BCS buruk (1-1,5 dalam skala 1-5), tidak ditemukan berahi, gambaran sitologi bagina didominasi sel parabasal dan transisional, respon terhadap pemberian preparat PGF2-alfa tidak menunjukkan adanya perubahan fisik alat kelamin, perilaku berahi, dan gambaran sitologi apus vagina. Hasil pemeriksaan USG tidak menunjukkan adanya status ovarium yang aktif. Hewan didiagnosa mengalami Undernutrition dan anestrus. Berdasarkan pemeriksaan fisik dan pendukung dapat disimpulkan faktor lingkungan berupa asupan pakan yang rendah dan kondisi tubuh yang buruk berpotensi mengakibatkan gangguan reproduksi pada kambing Bligon betina di masa usia produktif.
Measurement of Cosmetic Purchasing Decisions Using Brand Image and Consumer Trust
Authors: - Ngaliman , Amni Dafina , - Suharto , Lelawati Nina
Published: October 2021

This study aimed to measure the purchasing decisions of cosmetics using the brand image and consumer trust. This type of research is quantitative research and uses a sample of 70 respondents. The terms of the instrument test include the validity and reliability of the data. The analysis requirements used normal, homogeneous, linear, and regression significance tests. The data were analyzed using structural equations. The research findings show that brand image affects consumer trust, brand image affects purchasing decisions, and consumer trust also affects purchasing decisions.
Antibiotic Resistance Pattern of Pseudomonas aeruginosa Isolated from Clinical Specimens from a Tertiary Care Centre in Central Kerala with Special Reference to Carbapenemase Detection
Authors: Anooja P.M. , John Anu P.
Published: October 2021

Pseudomonas aeruginosa is inherently resistant to many drugs. It is now an emerging opportunistic pathogen of clinical relevance. The emergence of carbapenemases is another major concern. Initiation of appropriate therapy is of paramount importance thus highlighting the need of active surveillance for newer emerging resistance trends for better infection control. To study the resistance pattern of P. aeruginosa isolates obtained from lab specimens and to determine the production of ESBL and Carbapenemase among them. A hospital-based cross-sectional study was carried out in the Department of Microbiology, Government medical college Thrissur, among P. aeruginosa isolates obtained from lab specimens, from January 2018 – December 2018. 162 isolates were studied. Antimicrobial susceptibility testing was done by Kirby – Bauer disc diffusion method, extended-spectrum beta-lactamase (ESBL) production was confirmed by and phenotypic confirmatory disc diffusion test. Carbapenemase detection was done using the modified carbapenemase inactivation (mCIM) method. The obtained data was analysed. Among 162 isolates 83% were non-multidrug-resistant (MDR) strains and 17% were MDR strains. 22% of ceftazidime resistant isolates were ESBL producers. 6.2% isolates were resistant to imipenem. Among the imipenem resistant isolates, Carbapenemase production was seen in 30% isolates by mCIM test. According to our study, the most effective antibiotic against P. aeruginosa were imipenem and cefoperazone/sulbactam showing resistance in 6.3% and 6.9% isolates respectively. The diversity of antibiotic resistance mechanisms and the emergence of carbapenem resistance is a threat that limits treatment choices. This suggests the need for ongoing antimicrobial susceptibility studies in the future.
El acueducto romano de Ebusus
Authors: Marí Casanova Juan José
Published: October 2021

Los testimonios epigráficos referentes a la gens Cornelia muestran que la familia realizó diferentes actos de evergetismo hacia el pueblo de la isla de Ibiza, entre los que se incluía sufragar la construcción de un acueducto que suministrase agua a la ciudad del recién creado municipio flavio ebusitano. Por otra parte, la arqueología contemporánea ha localizado en ocho yacimientos diferentes tramos del acueducto que, junto a un testimonio de 1791, permiten reconstruir más de cinco kilómetros del trazado hipotético del acueducto hasta su llegada a la ciudad.
Negation and Conditional-Resultative Hypotactic Constructions in the Kartvelian Languages
Authors:   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, Lomia Maia , Chumburidze Nino ,   Arnold Chikobava Institute of Linguistics,, Ivane Javakhishvili Tbilisi State University, Georgia
Published: October 2021

The negative and affirmative forms create an opposition in which the negative form is marked by various language means, namely, affixes denoting absence, negative particles etc. Based on the empirical material of the Kartvelian languages, the paper analyzes issues of negation with regard to conditional-resultative hypotactic constructions. It is wellknown that condition is given in the subordinate clause, whereas the result is given in the main clause. In the Kartvelian languages conditional-resultative constructions may be affirmative and negative (containing the negative particle); the negative constructions embrace diverse types of context, depending on the function of the negative particle in the construction.
Inverted pyramid Azores - an eternal hybrid structure
Authors: Sarmento Esteves Luís Pedro F R
Published: October 2021

Engineering structures are designed with observation of rules for structural performance under specific design loads, defined in the so-called structural codes. While dead loads are directly dependent from the selection of structural materials to a given structural function, live and accidental loads are often linked to the region where the structure must perform. In a complete opposition to engineering principles in Ancient Egypt, the inverted pyramid was designed to become a statement of how to bend gravitational laws, and what can be achieved by modern engineering, sill with intelligence to fulfill its function in a region where engineering structures are subjected to extreme live and accidental load regimes, e.g. high risk of earthquakes and high wind seasonal loads. A hybrid structural concept was specified, comprising lightweight structural wall elements anchored to a relatively heavyweight structural core. The suggested design concept fulfills the global equilibrium equation defined by architecture, and should become a structural example from a structural design perspective. As any other project involving non-comprehensive geometry, design and construction of the inverted pyramid is highly sensible to management options, which shall assure high precision manufacturing, and accurate control of its production.
Properties and behavior of light hydrophobic concrete
Authors: Kharun Makhmud , Ehsani Armin , Nasimi Shahin , Gebre Tesfaldet H.
Published: October 2021

In concrete mixing plan, we usually encounter a combination of aggregates including sand, the amount of cement, which is actually the criterion of concrete grade, and the volume of water consumed. Changes in the quality and quantity of these components actually create the usual types of concrete. But the attitude that formed the basis of this research is based on the change in the nature of the components of the concrete mixing design. Removal of water and cement from the mixing plan and replacement of polymeric materials as well as the use of mixed LECA aggregates instead of aggregates is the basis of this research. In this paper, by examining and selecting LECA grain style and pre-treatment (hydrophobicity and coupling), in a constant ratio of resin, concrete samples were selected from three dimensional categories. After making the samples, flexural strength test was performed on them and the results were analyzed. Various compounds and processes have so far been proposed in the lightweight concrete mixing scheme. The distinctive point of this study is the use of lightweight expanded clay concrete with heat-treated acrylic polymer (crosslinking constituents) and related coupling agents. It is also important to select and apply the right amount of hydrophobic nanoparticles for hydrophilic surface hydrophobicity. Hydrophobicity was possible due to the non-polar nature of the acrylic polymer and the use of hydrophobic nanomaterials.
European Ai-Policy Space
Authors: Vykhodets R. S.
Published: October 2021

Artificial Intelligence (AI) is one of the central technologies of the fourth industrial revolution. A significant part of the production of surplus value in the XXI century is associated with the mastery and widespread introduction of technologies, which contributes to the consolidation of technological competition as an object of state policy and an important component of international relations. The European Union today occupies a leading position in the field of technology development and Since 2018 the EU is in the process of forming a unified strategy in the field of AI, the directions, principles and approaches of which are the main subject of this article.

The study is primarily based on the analysis of official documents included in the EU Strategy on AI: White Paper, Coordination Plan, Proposal for a Regulation establishing harmonized rules for artificial intelligence in the EU, documents of the expert groups of the European Commission, etc. The analysis of the EU policy to promote its own vision and approaches at the international level is based on theoretical models of the concept of “soft power” and the neo-institutional approach.

Against the backdrop of fierce global technological competition, the EU was one of the first in the world to form a holistic strategy for the development of AI technologies. This makes it possible not only to strengthen its own position as a world leader in the field of innovative technologies, but also to significantly expand the intra-European and international integration agenda, as well as to supplement the European arsenal of soft power with tools to promote its own norms, standards and ethical principles of AI development at the global level.

The key directions of the EU AI Policy are identified and disclosed. These include investments in technologies, creating conditions for their development, promoting development and implementation, creating an educational and regulatory environment, promoting the European vision of AI technology development at the international level. The authors considered key mechanisms of political regulation at the EU level, forms of interaction between stakeholders, approaches to promoting common principles in the field of ethics and security of AI technologies within the EU and at the international level.
The Role of the Country’s Status in the EAEU
Authors: Seryogina A. A. , Bogomolova V. E. , Harlanov A. S.
Published: October 2021

Integration associations in the modern world. Depending on the foreign economic and foreign policy priorities of the country, its status in the integration associations is designated. In the course of writing this article, based on empirical and theoretical research methods, it was possible to determine the difference between the types of participation of countries in international organizations, highlight the main reasons for countries to obtain observer status with the Eurasian Economic Union, and also analyze the prospects for expanding the integration association.
Terrorism as a Special Form of Political Fight in the Modern World
Authors: Odinaev D. S.
Published: October 2021

Terrorism is not a new phenomenon in human history, and since ancient times, various political and social forces have tried to seize power in this way, resorting to violence and intimidation. Various forces saw terrorism as a means of fighting their opponents. In the middle Ages, terrorism acquired a special status in European countries as a special form of political struggle to protect the interests of the state, church and religious authorities.

The very act of officially killing criminals in any form was committed with the aim of intimidating people and various sectors of society. The violence of the marginalized, expressed by the term “terror,” has become more common in modern French political history. The advocates of the reform saw the protection of the interests and freedoms of the individual with the help of terrorism as an effective means of political struggle. However, later this term was considered a negative act, and terrorism was presented as a crime against the state. That is, since the end of the 18th century, the term “terror” has been used in a negative sense.

Especially at the current stage of the development of human society, terrorism has acquired more frightening features. Terrorists kill innocent people to intimidate the public and authorities. Terrorism has become one of the main instruments of the struggle for power, the protection of group, ethnic, racial and other interests.
From the Belovezhskiye Agreements to the Eurasian Economic Union: 30 Years of Experience
Authors: Krotov M. I.
Published: October 2021

The article examines the reasons for the collapse of the USSR and the signing of the Belovezhskiye Agreements. The thirty-year experience of Eurasian integration in the post-Soviet space is summarized. There is an analysis of role of the Commonwealth of Independent States in the processes of regional economic integration carried out in the last decade of 20th century, in the context of the separation of the post-Soviet republics. It is shown that the members which are states of the Eurasian Economic Union and the Collective Security Treaty Organization fully fulfill the obligations assumed within the framework of the Belovezhskaya Agreements upon secession from the USSR. The article reveals the objective conditionality of the participation of the CIS countries in anti-Russian, pseudo-European projects by a policy of different directions. New economic priorities of Eurasian integration, institutional problems and prospects of the Eurasian Economic Union are investigated.
Trade and Economic Cooperation within the Framework of BRICS
Authors: Pogodin S. N. , Yagya T. S.
Published: October 2021

The article is devoted to trade and economic cooperation between Russia and the BRICS member

countries and trade cooperation within the BRICS Union. First, the authors study the peculiarities of

the development of the BRICS member countries and the possibilities of their trade cooperation within

the framework of this association. Trade and economic cooperation within the BRICS group is being

considered: structure of export and import supplies, dynamics of foreign trade turnover and features of

mutual trade. Authors consider the complementarity of the national economies of the BRICS countries,

about the competitive directions of each of its countries in the provision of certain services. The focus

is on the study of trade and economic cooperation between Russia and the BRICS member countries

in recent years. The article analyzes the export, import, and foreign trade turnover of Russia with each country of this organization. At the same time, all the calculations in the article are made independently based on statistical data. The authors identify the specifics of Russia’s trade cooperation within the BRICS grouping, draws relevant conclusions, and discusses the investment direction as a component of the growth of trade cooperation, the increase in foreign trade turnover, and GDP growth.
The Development Trajectory of the Eurasian Economic Union Is a One-Way Road
Authors: Kuklina E. A.
Published: October 2021

The EAEU, as one of the key integration associations of our time, is at the initial stage of its life cycle. This fact objectively presupposes, along with undoubted successes, the need for the EAEU to function in a problematic field, in the face of certain challenges, threats and risks. The main challenge to Eurasian integration is the “zero carbon footprint” and the EU’s intention to introduce a cross-border carbon tax as a tool for climate regulation. For a Eurasian response to the global challenge of zero carbon footprint, it is advisable to create an exchange of absorbing emissions within the EAEU. Experimental approaches, such as the introduction of an export duty on the carbon footprint, should to be used to create a funding mechanism for scientific and technical cooperation.
International Legal Features of the Constitutional Rights Implementation of the EAEU Member States Citizens in the Field of Pensions
Authors: Mishalchenko Yu. V. , Platonova L. A. , Toropygin A. V.
Published: October 2021

This article considers the pension provision of workers of the Eurasian Economic Union member states based on an analysis of the EAEU legislation and a comparative analysis of the domestic pension legislation of the EAEU member states in order to identify the features of their citizens’ social protection in the event of disability. The article discusses the procedure for organizing pensions provision with the application of an Agreement on Pension Provisions for Workers of the EAEU member states of 20 December 2019.
Antibody glycation during a CHO fed-batch process is following a constrained second order reaction
Authors: Pappenreiter Magdalena , Lhota Gabriele , Vorauer-Uhl Karola , Sissolak Bernhard
Published: October 2021

Glycation on lysine side chains of recombinant monoclonal antibodies
(mAb) is a well known phenomenon in manufacturing processes of
biopharmaceuticals that potentially alter the efficacy of the
therapeutic protein. Previously, we reported a method to quantify the
level of glycation formation directly from cell culture supernatants
using boronate affinity chromatography (BAC). In this study, we report
kinetic studies of glycation formation of the model protein Adalimumab,
related to glucose and non-glycated protein in six CHO fed batch
cultivations. An in-vivo model was demonstrated from glycation kinetic
studies that is capable of estimating the reaction rate constant in
static and dynamic bioprocesses, respectively. As anticipated, pseudo
first order reactions with respect to present glucose concentration or
non-glycated mAb were not sufficient to describe the glycation formation
during the bioprocesses. However, second order reactions did not reveal
linear relationship of glycated mAb to the product of glucose and
non-glycated mAb, suggesting a reconsideration of kinetic equation. With
the introduction of a constraint using only the newly formed product,
i.e., the nascent protein, the second-order reaction was successfully
implemented. These results show that the process knowledge derived from
dynamic can be transferred to static experiments and vice versa. Hence,
intensified DoE can be an applicable and useful tool in product quality
studies in cell culture processes.
Novel cost-efficient protein-membrane based system for cells co-cultivation and modeling the intercellular communication
Authors: Minin Artem , Blatov Igor , Lebedeva Valeria , Tuchai Maxim , Pozdina Varvara , Zubarev Ilya
Published: October 2021

In vitro systems serve as compact and manipulate models to investigate
interactions between different cell types. A homogeneous population of
cells predictably and uniformly responds to external factors. In a
heterogeneous cell population, the effect of external growth factors is
perceived in the context of intercellular interactions. Indirect cell
co-cultivation allows one to observe the paracrine effects of cells and
separately analyze cell populations. The article describes an
application of custom-made cell co-cultivation systems based on protein
membranes separated from the bottom of the vessel by the 3d printed
holder or kept afloat by a magnetic field. Using the proposed
co-cultivation system, we analyzed the interaction of A549 cells and
fibroblasts, in the presence and absence of growth factors. During
co-cultivation of cells, the expression of genes of the activation for
epithelial and mesenchymal transitions decreases. The article proposes
the application of a newly available system for the co-cultivation of
different cell types.
Effectiveness and safety of erenumab and galcanezumab in the prevention of chronic and episodic migraine: a retrospective cohort study
Authors: Viudez-Martinez Adrián , Pascual-Carrasco Angela , Blasco Isabel Beltrán , Hernandez-Lorido Raquel , Fuster-Ruiz-de-Apodaca Rosa
Published: October 2021

Aim and Methods: Erenumab and galcanezumab have shown great results for
migraine prevention in several clinical trials. However, strict
inclusion criteria, absence of concomitant medication and selective
outcome report may sometimes be barely representative of the real-world
daily practice. Therefore, this observational, retrospective,
non-comparative study was aimed to evaluate the effectiveness and safety
of erenumab 140 mg and galcanezumab 120 mg in real-world patients with
difficult-to-treat episodic or chronic migraine, who previously did not
respond to up to three well-stablished pharmacological alternatives for
migraine prevention. A combination of objective well-defined tools and
vastly used patient reported outcome measurements were evaluated at
baseline and after the administration of 3 and 6 doses. Results: from
180 patients, 142 matched inclusion criteria for the present study. Data
here reported shows that erenumab and galcanezumab reduced mean headache
days, acute migraine specific medication days, Headache Impact Test
score, Migraine Disability Assessment Test score and Visual Analogue
Scale score after 3 and 6 doses in real-world patients diagnosed with
difficult to treat chronic or episodic migraine (p<0.01).
Moreover, acute migraine specific medication days were reduced by a half
in, at least, a 50% of the patients enrolled in each of the groups of
the study. Both treatments exhibited a great safety profile, rarely
leading to discontinuation because of poor tolerance. Conclusions:
Erenumab and galcanezumab seem effective and well tolerated for migraine
prevention in real-world patients with episodic or chronic migraine who
previously failed to oral preventive therapies.
Simulation and Optimization of the Phosgenation Reactive Distillation Process for Producing Toluene Diisocynate
Authors: Bi Rong , Sun Xiaoyang
Published: October 2021

Toluene diisocyanate (TDI) is an important chemical intermediate
prepared by phosgenation reaction between toluene diamine and phosgene
with two steps name cold and thermal phosgenation respectively. In this
paper, the reactive distillation model for the thermal phosgenation
reaction based the kinetics equations was established for an industrial
installation, and the effects of the different parameters on the process
performance were studied firstly; then based on the analysis results, a
thermal coupling process between the towers of reactive distillation and
phosgene purification was presented and investigated; finally, the
optimal operation scheme was simulated and the results showed that the
proposed process can save the heat and cold energy with 7.29% and
32.78%, respectively, and reduce the total annual cost about 17.11%.
The result of the paper can be used to guide the operation configuration
or the revampment of the TDI production equipment.
Stochastic Swarms of Jumping Robots for Large-scale Environmental Sensing
Authors: Hird Julian , Conn Andrew , Hauert Sabine
Published: October 2021

Single-use jumping robots that are mass-producible and potentially
biodegradable could be quickly released for environmental sensing
applications. Such robots would be pre-loaded to perform a set number of
jumps, at random directions and distances, removing the need for onboard
energy and computation. Stochastic swarms build on embodied randomness
and large-scale deployments to perform useful work. This paper
introduces simulation results showing how to construct a stochastic
swarm of jumpers to perform environmental sensing, and the first
demonstration of robot prototypes which can perform a set number of
sequential jumps, full-body sensing, and have the potential to be
biodegradable.

Corresponding author(s)
Email: a.conn@bristol.ac.uksabine.hauert@bristol.ac.uk
Analysis of the State of Territorial Communities to Model Their Socio-Economic Development
Authors:   Lviv Polytechnic National University, Bihun Roman , Lytvyn Vasyl ,   Lviv Polytechnic National University, Oleksiv Nazar ,   Lviv Polytechnic National University
Published: October 2021

The problems of development of united territorial communities, in particular unemployment and economic problems, are considered. Communities, in most cases, lack the resources to address economic and other issues. Therefore, it is necessary to create self-sufficient communities in which there are enough financial instruments for their own development. The mathematical model of the decision support system for the development of territorial communities using the agro-industrial sector was considered. An important step in building a mathematical model of the agro-industrial complex is to take into account the specifics of agriculture. The article considers a mathematical model of linear multifactor regression, which describes the relationship between the number of resources expended and the volume of output. Since the processes of economics and production processes of agriculture are complex, it is difficult to describe them using only linear deterministic models. It is common for task variables to take some discrete values or values from a certain interval. This situation makes the search difficult.
Designing and Implementation of the Information System for Providing Recommendations to People with Mental Disorders
Authors:   Lviv Polytechnic National University, Zakharchuk Marko , Basyuk Taras ,   Lviv Polytechnic National University
Published: October 2021

The authors of the article have developed methodological grounds, designed and implemented an information system to provide recommendations to people with mental disorders. The analysis of the main ways of using information technology in mental health treatment has resulted in the finding that mobile devices with certain software can significantly reduce the number of visits to qualified specialists, which make mental health therapy much more accessible to people with limited time or material resources. The authors have designed the information system using a structural approach and design model Data Flow Diagrams (DFD). They have also developed a context diagram of the information system and decomposed its main process to demonstrate ways to convert input into output. The authors have described the features of the decision-making method — the decision tree used in the information system. The functional purpose and the algorithm of work have been presented in the form of a Petri net, also the authors have specified on the tables of positions and transitions of this network for a better understanding of system principles. The analysis of software tools has been done that allows us to achieve the set goals in designing the system. Verification of work has been carried out which is proved in screenshots of program windows of the system and contents of the main pages has also been described.
Self-organizing Strategies in Game of Agent Movement
Authors:   Lviv Polytechnic National University, Kravets Petro
Published: October 2021

In this paper, a stochastic game model of self-organization of strategies of stochastic game of mobile agents in the form of cyclic behavioral patterns, which consist of coordinated strategies for moving agents in a limited discrete space, is developed. The behavioral pattern of a multi-agent system is a visualized form of orderly movement of agents that arises from their initial chaotic movement during the learning of a stochastic game. The mobility of multi-step stochastic game agents is ensured by the fact that in discrete moments of time they randomly, simultaneously and independently choose their own pure strategy of moving in one of the possible directions. Current player payments are defined as loss functions that depend on the strategies of neighboring players. These functions are formed from the penalty for irregular spacing of agents in a limited discrete space and the penalty for collisions when moving agents. Random selection of players’ strategies aims to minimize their average loss functions. The generation of sequences of pure strategies is performed by a discrete distribution based on the vectors of mixed strategies. The elements of the vectors of mixed strategies are the conditional probabilities of choosing the appropriate pure displacement strategies. Mixed strategies change over time, adaptively taking into account the value of current losses. This provides an increase in the probability of choosing those strategies that lead to a decrease in the functions of average losses. The dynamics of the vectors of mixed strategies is determined by the Markov recurrent method, for the construction of which a stochastic approximation of the modified condition of complementary non- rigidity, which is valid at Nash equilibrium points, is performed, and a projection operator for expandable unit epsilon simplex is applied. The convergence of the recurrent game method is ensured by compliance with the fundamental conditions and limitations of stochastic approximation. The stochastic game begins with untrained mixed strategies that set a chaotic picture of moving agents. During the learning of the stochastic game, the vectors of mixed strategies are purposefully changed so as to ensure an orderly, conflict-free movement of agents. As a result of computer simulation of stochastic game, cyclic patterns of self-organization of mobile agents on the surface of a discrete torus and within a rectangular region on a plane are obtained. The reliability of the experimental studies was confirmed by the similarity of the obtained patterns of moving agents for different sequences of random variables. The results of the study are proposed to be used in practice for the construction of distributed systems with elements of self-organization, solving various flow and transport problems and collective decision-making in conditions of uncertainty.
Definition of Professional Vector in Educational Systems of Training Future It Specialists
Authors:   Lviv Polytechnic National University, Dubas Yurii , Kunanets Nataliia ,   Lviv Polytechnic National University
Published: October 2021

Nowadays, the quality of vocational education directly depends on such characteristics as readiness for independent work, individualization of programs, self-improvement and self-development, the ability to acquire knowledge and use them productively in professional activities. Thus, the individualization of education plays an important role. This article describes and analyzes the method of determining career guidance, known as the John Holland test, presents a model of its work and justifies the results. Also, the previously implemented recommendation system is mentioned and considered, which allows to form an individual educational trajectory for students of IT specialties. This system uses a sub-module for determining career guidance, which is implemented on the basis of the Dutch test. Accordingly, the use of the Dutch method in the work of the recommendation system for the formation of an individual educational trajectory will provide a more accurate and desirable result. Holland’s test was also used to survey the graduating class to choose an IT profession and showed unexpected results.
Evaluasi dan proyeksi kinerja jalan studi kasus ruas jalan arteri Gunung Sugih-Terbanggi Besar Lampung Tengah
Authors: Romdhani Rohmat , Sulistyorini Rahayu , Utoyo Bambang
Published: October 2021

Perubahan tata guna lahan yang sangat cepat mempengaruhi perubahan sistem transportasi dan sarana prasarana tranportasi. Tujuan penelitian ini adalah menganalisis volume lalu lintas, kapasitas ruas jalan, kinerja simpang dan alternatif solusi untuk mengatasi kemacetan serta menganalisis pengaruh tata guna lahan terhadap volume lalulintas. Lokasi penelitian berada di Ruas Jalan Arteri Gunung Sugih – Terbanggi Besar, Kabupaten Lampung Tengah. Metode yang digunakan dengan melakukan survei lalu lintas, mengumpulan data, analisis tarikan bangkitan akibat tata guna lahan dan analisis dengan MKJI 1997. Berdasarkan analisis, diperoleh hasil untuk kapasitas ruas jalan Gunung Sugih – Terbanggi Besar pada periode 5 tahun (tahun 2025) dalam kondisi baik, periode 10 tahun (tahun 2030) diperlukan menerapkan skenario 2. Untuk simpang empat Pasar Bandar Jaya, pada periode 5 tahun (tahun 2025) menerapkan skenario 1, Pada periode 10 tahun (tahun 2030) menerapkan skenario 2. Dari analisa tarikan bangkitan, pergerakan didominasi oleh kawasan Pasar Bandar Jaya yaitu 1.543 Smp/Jam (92,2%). Sehingga untuk mendukung wilayah Pasar Bandar Jaya diperlukan sarana prasarana untuk mendukung aktivitas kehidupan seperti JPO, pedestrian, fasilitas angkutan umum, halte bus, kantong parkir dan lain sebagainya.
Ultrasound in the Detection of Floating Sialoliths
Authors: Tymofieiev Oleksii , Cherniak Olha
Published: October 2021

A 36-year-old man with a 3-year history of recurrent
salivary colic was referred to a maxillofacial surgery
department. Gray scale ultrasound (US) showed
enlarged right submandibular gland, significantly
dilated intraglandular duct with two sialoliths (with an
artifact of acoustic shadowing) inside, one – floating
(Video-Panel A and B, arrow) and another – nonmovable
(arrowhead). Left nonsymptomatic normal in
size gland (asterisk) is showed at Panel C. The affected
gland was excised under general anesthesia due to
the diagnosis of chronic submandibular obstructive
sialolithiasis. Intraglandular duct contained two yellowish stones, first was an oval form with a pellet surface (Panel D, arrow), second – a round shaped
with a smooth surface (Panel D, asterisk) and it
was presented at US as a floating sialolith; both are
easily crumbled on palpation. As the specimen and
intraglandular duct were dissected longitudinally,
that`s why dissected intraglandular duct (Panel D,
arrowheads) is visible in both parts of the gland.
Also, a 1 small calculus (Panel D, curved arrow) was
found in the parenchymal ducts. Postoperative period
was smooth, and 1-year follow-up after surgery, the
patient has no complaints.
PENYELESAIAN PEMBIAYAAN BERMASALAH PADA BANK SYARIAH
Authors: Khairunisa Madona
Published: October 2021

Metode penelitian ini adalah  penelitian perpustakaan, Untuk mencapai tujuan tersebut Penulis memakai metodologi penelitian bersifat kualitatif. Sumber data diperoleh langsung melalui literatur yang berkaitan dengan objek penelitian. Setelah data terkumpul dengan lengkap baru dianalisa secara deskriptif dengan metode analisis deduktif dimana data-data umum yang telah dikumpulkan ditarik kesimpulan secara khusus. Setelah dilakukan penelitian maka didapatkan kesimpulan bahwa Pola penyelesaian pembiayaan bermasalah pada bank syariah dapat dilakukan dengan cara:1.Restrukturisasi. restrukturisasi yang dapat dilakukan adalah Penjadwalan kembali (rescheduling), Persyaratan kembali (reconditioning), Penataan kembali (restructuring), Penjadwalan kembali (rescheduling) 2. Penyelesaian melalui jaminan. 3.Collection Agent dan 4. Hapus Buku (write off).
El juego-trabajo como estrategia de enseñanza-aprendizaje en Educación Inicial
Authors: Pillajo Tipán Evelyn Gissela , Villarroel Dávila Paola Carina , Quezada Loaiza Enith Elizabeth , Guijarro Vinces Johanna Stefanía
Published: October 2021

En la actualidad, la educación se ha transformado y con ello  las metodologías y estrategias pedagógicas utilizadas por los docentes, este es el caso de la educación Inicial, que propone la metodología juego-trabajo como una  alternativa para generar experiencias de aprendizaje significativas e innovadoras en los niños, evitando esquemas tradicionales enfocados  en actividades dirigidas sin la posibilidad de la experimentación y movimiento.  Por ello, el presente estudio se enfoca en averiguar cuánto conocen los docentes  sobre la implementación de la metodología juego-trabajo y su implementación  como estrategia de enseñanza-aprendizaje en educación inicial. Para este  propósito se realizó una investigación de tipo cuantitativa y descriptiva, con una  población de cincuenta y dos docentes del nivel de educación inicial de la ciudad  de Quito, a quienes se les aplicó un cuestionario validado y piloteado sobre la  utilización de la metodología juego-trabajo. Luego de analizar los resultados, se  determinó que el 67,3 % de los docentes si aplican la metodología juego-trabajo durante el proceso de enseñanza-aprendizaje, pero no poseen una comprensión  clara de los conceptos ni las técnicas que se pueden emplear dentro de la  metodología. Esta carencia de fundamentos conceptuales conduce a una mera  aplicación por el simple hecho de cumplir con las exigencias establecidas en el  currículo, corriendo el riesgo de una aplicación sin criterios de innovación y  creatividad.
Nivel de conocimiento de protocolos de primeros auxilios en docentes de educación inicial y preparatoria de instituciones educativas de la ciudad de Quito
Authors: Murillo Loján María Teresa , Vargas Fuertes Erika Marlene , López Sevilla Janeth Del Pilar
Published: October 2021

Los protocolos de primeros auxilios dentro de las instituciones educativas tanto públicas, privadas o municipales de la ciudad de Quito, relacionados a la Educación Inicial y Preparatoria, son temas que deben ser prioritarios, con énfasis en la preparación de las/os docentes, en razón de ser ente principal de cuidado y enseñanza de los niños/as. Por tanto, es necesario que estén calificados para brindar la asistencia a sus estudiantes ante algún accidente dentro de las instalaciones de los centros infantiles. Propósito: Valorar los conocimientos de los protocolos de primeros auxilios en autoridades y docentes de Educación Inicial y Preparatoria de los establecimientos educativos en Quito. Sujetos y métodos: Estudio multicéntrico, observacional, transversal de una cohorte. Población: 54 docentes y autoridades de educación inicial y preparatoria de la ciudad de Quito, de agosto a septiembre de 2020. Resultados: En cuanto a capacitación de primeros auxilios, el 80% de educadores encuestados recibieron preparación en el tema; mientras el 20 % restante no recibieron capacitación de primeros auxilios durante su formación. En ese contexto buscó conocer si los docentes poseen conocimiento de primeros auxilios, resultando que el 98 % sabía a qué se refiere el término; mientras que el 2% no conocían. Conclusión: Se concluyó que la capacitación, teórica y práctica, de primeros auxilios es una herramienta fundamental para precautelar la integridad física y psicológica de las/os niños.
Psychological Precursors and Manifestations of Daily Beyond-Duties Engagement Within the Assistance and Creative Professions
Authors: Bożek Agnieszka
Published: October 2021

The study’s first goal was to explore and analyze ‘beyond-duties engagement’ (employee engagement that exceeds basic professional duties) within the assistance and creative professions. The second goal was to explore relationships of daily beyond-duties engagement with autonomy in action, feedback from others, positive affect and subjective assessment of one's competences. Each participant completed a daily diary for 5-6 days, and data were obtained from 64 employees, aged 21-61 (M = 38.91, SD = 8.99), from each profession. Qualitative sorting of beyond-duties engagement yielded twelve categories with forty subcategories. Hierarchical linear modelling demonstrated a positive relationship between feedback from others and subjective assessment of one's competences with enhanced beyond-duties engagement. A mediation role of positive affect was also observed. When considered within the relevant organizational context, these findings may help predict how an employee, from a given profession, is likely to respond to specific, positive stimuli at work.