bluuebunny/crossref_metadata_2025 huggingface dataset:
Gastric Residual Volume Assessment by Gastric Ultrasound in Fasting Obese Patients: A Comparative Study
Authors: Mohammad Khalil Atef , Gaber Ragab Safaa , Makram Botros Joseph , Ali Abd-aal Hazem , Labib Boules Maged
Published: February 2021

Background: Gastric ultrasound is an emerging tool for preoperative evaluation of gastric content and volume. Objectives: To assess gastric residual volume in normal-weight and obese patients scheduled for elective surgery. Methods: This prospective observational study was conducted on 100 patients assigned to two groups of 50 patients each. The obese group included patients with body mass index (BMI) of 30 - 40 and American Society of Anesthesiologists (ASA) grade II and those with BMI > 40 and ASA III without other comorbidities; the normal-weight group included patients with normal BMI and ASA I. Gastric volume was predicted in each group using sonographic measurement of antral cross-sectional area (CSA) in semi-sitting and right lateral positions (RLP); the two groups were compared to assess the risk of aspiration for each group preoperatively. Results: Despite intergroup differences in antral CSA, the sonographically predicted gastric volume was < 1.5 mL/kg in both groups in both positions. Both groups were at a low risk for aspiration, and 98% of the patients showed grade 0 or 1 in antrum assessments, corresponding to an empty antrum and minimal fluid only in the RLP, respectively. Only 2% of the patients in both groups showed a distended antrum in both positions. Conclusions: Despite the differences in CSA between obese and normal-weight participants in both positions (obese > normal-weight), both groups showed a low predicted gastric residual volume < 1.5 mL/kg and were at low risk for aspiration, provided that fasting was initiated at least 8 hours before elective surgery.
Langerhans Cell Histiocytosis; Managing an Uncommon Condition in Pregnancy and Labor: A Case Report
Authors: Martins Inês , Castro Mafalda Amorim , Vieira Daniel , Raimundo Ana
Published: February 2021

Introduction: Langerhans cell histiocytosis (LCH) is a rare heterogeneous disease that normally occurs in children under 15 years but can rarely be diagnosed in adulthood. It can affect any organ of the body, and a less favorable prognosis is expected when either liver, lung, spleen, or bone marrow are affected. Diabetes insipidus, from pituitary dysfunction, is one of the most common consequences that can develop anytime during the disease, and symptoms normally worsen during pregnancy. Pregnancy with this disease is uncommon, and when it occurs, a cesarean section is normally performed. Case Presentation: We report a 34-year-old pregnant woman (37 weeks and two days gestation) with the diagnosis of a disseminated LCH at the age of 30 who presented herself at the obstetrics emergency department due to respiratory distress. During pregnancy, her pulmonary function remained stable, and she was asymptomatic until the last two days before she was admitted. Labor was induced, with vaginal misoprostol, to achieve a vaginal birth with epidural analgesia. The child was born without complications, and the patient had an immediate clinical improvement. In the following three months, she remained asymptomatic without any worsening of her disease. Conclusions: In LCH, a cesarean section is the first choice in many cases due to pulmonary impairment. We concluded that early placement of an epidural catheter allows labor analgesia while safeguarding the possibility of an epidural anesthesia in case of urgent/emergent cesarean section. If pulmonary function remains stable, vaginal delivery is possible, thereby being less invasive and allowing for a faster recovery.
Wilson’s Disease with Hepatogenous Diabetes: A Case Report
Authors: Zhong Shuwen , Deng Zhaohui , Jiang Lirong , Zeng Jingqing , Yu Tingting
Published: February 2021

Introduction: Wilson’s disease (WD) is a hereditary autosomal recessive disorder caused by pathogenic variants within the ATP7B gene. Early diagnosis of WD is important but it can be difficult in pediatric clinical practice because of varied presentations. Fortunately, with the development of genetic testing, molecular analysis of the ATP7B gene is helpful in the early diagnosis of WD. Hepatogenous diabetes (HD) is defined as a state of impaired glucose regulation caused by chronic liver disease. Here we report a child with WD with HD. Case Presentation: A 4-year-old girl was admitted to our hospital with diarrhea for two months. On admission, urine glucose was 4+, fasting glucose was 2.6 mmol/L, and postprandial blood glucose was 7.2 mmol/L. Further clinical manifestations and laboratory tests showed coagulation dysfunction, hemolytic anemia, and cirrhosis. After admission, she developed hepatic encephalopathy. Significant abnormal glucose metabolism was later detected, but by then, hypoglycemic convulsions had taken place. The final diagnosis of WD was confirmed by detection of mutations in the ATP7B gene. Genetic sequencing revealed compound heterozygous mutations in ATP7B, including c.2975C>T, p.Pro992Leu and c.3809A>G, p.Asn1270Ser. On day 40 of admission, the patient underwent successful orthotopic liver transplantation. Her liver function, blood glucose levels, and coagulation test results returned to normal one month after the liver transplantation. The symptom of diarrhea was also relieved after surgery. Her abnormal glucose level in hospital was considered to be HD. Conclusions: Blood glucose levels must be carefully monitored in Wilson’s disease. Moreover, genetic sequencing provides an accurate and minimally invasive diagnostic tool for WD.
An Experimental Evaluation of the Effect of SOLID Principles to Microsoft VS Code Metrics
Authors: Turan Osman , TANRIÖVER Ömer Özgür
Published: February 2021

Software maintenance is necessary for reasons such as changes in user needs, changes in the operating conditions of the system due to changes in the infrastructure, the occurrence of unforeseen errors. The suitability of the software for maintenance operations is a significant influence in reducing the cost. Using only basic object oriented programming concepts do not show that we are writing maintainable code in our applications. Object oriented design principles such SOLID are about reducing dependencies and increasing maintainability. ISO/IEC 9126 is about maintainability but ISO/IEC 9126 is not clear about whether all inputs to measurement should be used together in conjunction or whether they should be used as appropriate or available. Indeed, ISO/IEC 9126 provides no guidance, heuristics, rules of thumb, or any other means to show how to trade off measures, how to weight measures or even how to simply collate them. In this study each sub-characteristic of ISO/IEC maintainability with help of Visual Studio VS code metric tool is assessed. The focus of this assessment is on maintainability and its sub-characteristics like analyzability, testability, changeability and stability. Before doing an analysis, each sub-characteristics of maintainability part of ISO/IEC 9126 standard are mapped to five VS code metrics for measurement of characteristics. This work shows the effect of object oriented design principles SOLID to the maintainability, complexity and flexibility of the code while associating ISO/IEC, VS code metric and SOLID.
Behaviour of thermostone blocks with and without cement mortar plastering exposed to high temperatures
Authors: Abdulhussein Faisal , Frayyeh Qais , Al-Shaikhli Marwan , Fakhri Jawad , Salman Mohammed
Published: February 2021

Autoclaved aerated concrete (called Thermostone in Iraq) is one of the popular building materials that are used in various purposes in construction industries. It is factory-made material that can be moulded into blocks which can be used in framework buildings. However, these buildings are under the risk of fire since it has different cusses such as arson and electrical short circuit. It is important to find ways to improve counter such phenomenon. Therefore the objective of this paper is investigating the fire resistance performance of Thermostone with and without plastering. Five different samples were used for the test, four of them were covered with different types of plastering. Three tests were employed for this study: Compressive, absorption, and density test. For all tests, the samples were exposed to elevated temperatures from 250°C to 900°C. It was shown that the compressive strength are reduced when exposed to high temperature by up to 75%, however the air-cooled samples are less affected by approximately 15%. Furthermore, plastered samples has lower absorption rate than non-plastered ones. Finally, density decrease with heat by up 10% approximately.
CONTRIBUCIONES DE LA FENOMENOLOGÍA DE EDITH STEIN AL PROBLEMA MENTE-CUERPO: APUNTES PARA LA PSICOLOGÍA
Authors: Akira Goto Tommy
Published: February 2021

La psicología es una rama científica relativamente nueva y a la que todavía le faltan bases metodológicas consistentes para fundamentar sus investigaciones. Dada su inmadurez, tal ciencia tiene dificultades para delimitar su estatuto ontológico, lo que genera diversos equívocos epistemológicos y metodológicos. Así, se impone una cuestión fundamental para la aclaración del objeto de la psicología: el problema mente-cuerpo. En ese sentido, el objetivo de este artículo, basado en la fenomenología de Edith Stein, es analizar algunos trabajos de la filósofa, a saber: “Causalidad Psíquica” e “Introducción a la Filosofía”. De esa manera, a través de las investigaciones de Stein acerca de la psique (que puede situarse en la cercanía de lo que se entiende por mente en el ámbito de las ciencias de la mente) y del cuerpo, se concluye que es posible concebir la cuestión psique/mente-cuerpo como una unidad-dual que se instancia en el Leib.Psychology is a relatively new scientific branch that still lacks consistent methodological foundations to support their investigations. Given their immaturity, that science still faces difficulties to delimit its ontological status, which raises various epistemological and methodological misconceptions. Thus, there is a fundamental question for an elucidation of the object of Psychology: the mindbody problem. The proposal of this article, in this sense, is to discuss the mind-body problem in the light of the Phenomenology of Edith Stein, seeking from there lay the fundation of Psychology. For this, some works of the philosopher was analysed, namely: “Psychic Causality” and “Introduction to Philosophy”. In this way, through the investigations of Stein about the psyche (which can be approximated to what is meant by mind in the context of the Sciences of the mind) and body, concluded that it is possible to conceive the psyche/mind-body issue while a dual-unit that instantiates in the Leib.
LA INVESTIGACIÓN TRASCENDENTAL DE CHARLES TAYLOR
Authors: Rodríguez García Sonia E.
Published: February 2021

Taylor analiza la investigación trascendental como el método propio de la filosofía en una serie de artículos tempranos. El objetivo de este artículo es doble. En primer lugar, queremos acercar al lector a las bases filosóficas del pensamiento de Taylor, exponiendo el descubrimiento y los análisis de Taylor sobre la investigación trascendental. En segundo lugar, queremos mostrar la necesidad de atender a la metodología y a las fases de esta investigación trascendental para la correcta interpretación e identificación de la filosofía de Taylor.Taylor analyzes transcendental investigation as the proper method of philosophy in a serie of early articles. The purpose of this article is double. First, we want to bring the reader closer to the philosophical foundations of Taylor's thought, exposing Taylor's discovery and analysis of transcendental investigation. Second, we want to show the need to attend to the methodology and phases of this transcendental investigation in order to achieve the correct interpretation and identification of Taylor's philosophy.
LOS PASOS PERDIDOS. ESCRITOS DE GAOS SOBRE ORTEGA, POR JOSÉ LASAGA
Authors: San Martín Javier
Published: February 2021

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Marcela VENEBRA MUÑOZ: "La reforma fenomenológica de la antropología". Bogotá, Editorial Aula de Humanidades/ Universidad de San Buenaventura, 2017, 359 PP.
Authors: Expósito Ropero Noé
Published: February 2021

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¿EN QUÉ SENTIDO MI CUERPO ES MÍO? EL “CUERPO PROPIO” EN IDEEN II Y PHÉNOMÉNOLOGIE DE LA PERCEPTION
Authors: García Esteban A.
Published: February 2021

El artículo confronta el análisis merleau-pontiano de los cuatro caracteres del “cuerpo propio” en Phénoménologie de la Perception (I.2) con el tratamiento original que Husserl realizó de los mismos puntos en Ideen II (II.3). Se examinan sus respectivos análisis de la permanencia absoluta, las sensaciones dobles, las cenestesias y las cinestesias para determinar el diferente significado que comporta el “cuerpo propio” para cada autor. Se observa así que las “ubiestesias” no desempeñan para Merleau-Ponty el rol constitutivo del cuerpo propio que tienen para Husserl. Esto conduce a distinguir, siguiendo a Husserl, dos sentidos diferentes de propiedad. Mientras que Husserl asocia el cuerpo propio con un sentido secundario de propiedad, derivado de un sentido yoico originario, para Merleau-Ponty la experiencia más básica del yo y de lo propio es vivida por un sujeto cor-poral al percibir y moverse.The article confronts the MerleauPontyan analyses of the four features of the “body proper” in Phénoménologie de la Perception (I.2) with the original Husserlian consideration of the same issues in Ideen II (II.3). I examine their analyses of absolute permanency, double sensations, cenesthesis and kinesthesis, to determine the different meaning that the “body proper” acquires for each author. It is thus observed that “localized sensations” do not play for Merleau-Ponty —as they do for Husserl— the constitutive role of the body proper. This leads to distinguish, following Husserl, two different senses of ownership. Whereas Husserl associates the “body proper” with a secondary sense of ownership deriving from an originary sense of self, for Merleau-Ponty the most basic experience of myself and of ownership is lived by a corporeal subject in perception and movement
ACERCA DE LA EXPERIENCIA DE LA ENFERMEDAD: FENOMENOLOGÍA, CORPORALIDAD Y HABITUALIDAD
Authors: Passerino Leila Martina
Published: February 2021

Merleau-Ponty se vale de casos patológicos para elaborar una teoría de la percepción que ubica a la corporalidad como expresión central. El artículo indaga y problematiza la experiencia de enfermedad a partir de la propuesta fenomenológica en torno al cuerpo vivido o fe-nomenal. Repensar esta vivencia, desde las antípodas a un abordaje biomédico que la circunscribe a un cuerpo objetivo, permite considerarla a la luz de una perspectiva filosófica como instancia crítica. La experiencia de enfermedad, inaugura una disrupción en el modo de ser-en-el-mundo e introduce la inhabitualidad, como dimensión que participa de una reconfiguración necesaria del esquema corporal. Este aspecto permite repensar los procesos de salud/enfermedad y discutir con concepciones de índole restitutivas, tan características a la hora de abordar los mismos.Merleau-Ponty uses pathological cases to elaborate a theory of perception that places corporality as the central expression. The article investigates and problematizes the experience of illness from the phenomenological proposal around the lived or phenomenal body. Rethinking this experience, from the antipodes to a biomedical approach that circumscribes it to an objective body, allows us to consider it in the light of a philosophical perspective as a critical instance. The experience of illness inaugurates a dis-ruption in the way of being-in-the-world and introduces the unusual, as a dimension that participates in a necessary reconfiguration of the body scheme. This aspect allows to rethink the health / disease processes and to discuss with concepts of a restorative nature, so characteristic when it comes to addressing them.
LA FENOMENOLOGÍA Y LA CLAUSURA DE LA METAFÍSICA: INTRODUCCIÓN AL PENSAMIENTO DE HUSSERL
Authors: Derrida Jacques , Hrdz Marcelo traductor Jimmy
Published: February 2021

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L'ubica UČNIK and Anita WILLIAMS (eds.). Phenomenol-ogy and the Problem of Meaning in Human Life and History. Nordhausen: Traugott Bautz, 2017, 345 pp.
Authors: Bueno Junquero Adrián
Published: February 2021

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M.ª CARMEN LÓPEZ SÁENZ, La hermenéutica filosófica de H.-G. Gadamer en busca de la verdad, Madrid, Dykinson, 2018, 208 pp.
Authors: Lavernia Kilian
Published: February 2021

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EL PROBLEMA DE DIOS EN LA FENOMENOLOGÍA DE HUSSERL. ANGELA ALES BELLO, Edmund Husserl. Pensar a Dios, creer en Dios. Buenos Aires: Editorial Biblos, 2016
Authors: Sánchez Muñoz Rubén
Published: February 2021

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Roller Coasters and Quadratic Equations
Authors: Ferguson Sarah , Johnston Thomas , Karhan Christopher , Lefevbre Eric
Published: February 2021

Students explore the relationship between thrill-seeking rides and their algebra 1 curriculum in an informative, engaging, student-centered lesson that was designed using a project-based-instruction (PBI) framework.
Engaging Students through Modeling
Authors: Magaletto Rocco
Published: February 2021

How would students feel when learning through the use of mathematical modeling? On investigation, this article reveals that students felt better prepared for assessments, learned valuable life skills, and saw the relevance of mathematics to their lives outside of the classroom.
Noticing and Wondering to Guide Professional Conversations
Authors: Dobie Tracy E. , Anderson Eleanor R.
Published: February 2021

This article explores how teachers can use the sentence stems “I notice” and “I wonder” to deepen professional conversations with colleagues, both in person and in online spaces.
Crescimento e adaptabilidade de procedências e progênies de Pinus tecunumanii no Norte de Moçambique
Authors: Dias Cremildo Riba Gouveia , Mbanze Aires Afonso
Published: February 2021

Empresas florestais necessitam maximizar lucros e minimizar o nível de risco e incerteza, sendo uma das principais estratégias plantar povoamentos de crescimento rápido e de alta produtividade. Foi com esse intuito que a Empresa Florestas do Niassa, estabeleceu um experimento com cinco procedências e 28 progênies de P. Tecunumanii Eguiluz & Perry, no norte de Moçambique. O experimento foi estabelecido em blocos ao acaso com quatro linhas de repetição. Aos dois, quatro e oito anos de idade foram medidas altura total, diâmetro altura do peito (DAP) e sobrevivência. Os resultados de sobrevivência aos oito anos de idade não apresentaram diferenças significativas, tendo ficado acima dos 90% para todas as procedências incluindo a testemunha. Houve diferenças significativas de crescimento entre procedência para os restantes parâmetros avaliados. O melhor desempenho aos oito anos foi para as procedências Villa Santa, San Rafael del Norte e Yucul. O desdobramento das procedências entre progênies com o uso do recurso de agrupamento de clusters identificou três grupos distintos: O primeiro, composto pelas 12 (41,38%) progênies de melhor desempenho, majoritariamente da Villa Santa e Yucul; o segundo intermediário e composto por sete (24,14%) das progênies, na sua maioria de Yucul e Km 33; o último foi composto por 10 (34,4%) das progênies de pior desempenho, na sua maioria de San Jeronimo e Km 33. A maior parte das 10 melhores progênies classificadas com base no efeito genético aditivo predito e ganho genético, pertencem a Villa Santa, confirmando os resultados dos clusters. Já a maioria das progênies (45%) ao nível dos 20 melhores indivíduos classificados, pertenceram a procedência Villa Santa e podem ser usadas para futuros projetos de melhoramento no ambiente do Niassa. A seleção das melhores progênies pode ser feita a partir do DAP, dado que este apresentou um coeficiente de correlação acima dos 90% com o volume.
First report: Amazon River Prawn reared in biofloc technology
Authors: Jatobá Adolfo , Legarda Esmeralda Chamorro , Stockhausen Larissa , Vieira Felipe do Nascimento
Published: February 2021

The objective of this work was to evaluate the use of biofloc technology to reared Amazon River prawn (Macrobrachium amazonicum). One hundred Amazon River prawn juveniles were divided into two experimental units (250 L), 50 animals per each. Prawns were fed two times per day, with 3% of the prawn biomass.  Dissolved oxygen and temperature were performed twice a day. Total suspended solids, pH, alkalinity, ammonia nitrogen, nitrite and nitrate were monitored twice a week. Prawns showed 77.67%, survival, 2.98 feed conversion, weekly weight gain of 0.29 g day-1, and yield of 822.0 g m-3 after six weeks of rearing. Dissolved oxygen, temperature and pH were suitable for the species, however, for some weeks, ammonia nitrogen and nitrite were higher than the limits recommended for prawn. In conclusion it is possible to use BFT to maintain and rearing Amazon River Prawn (M. amazonicum), however to improve the performance it is necessary to define nutritional requirements, as well improve the management techniques for this species in BFT.
disputas en torno a la designación de veedores en el gremio de los pelaires. Murcia, 1450-1510
Authors: FAZZINI Mauro
Published: February 2021

En el presente trabajo nos proponemos analizar las tensiones existentes, entre mediados del siglo XV y principios del XVI, dentro del gremio murciano de los pelaires en torno a la designación anual de sus autoridades principales, los veedores. En este período, la elite dirigente busca hacerse con el monopolio del cargo en cuestión, mientras que un sector del artesanado resiste esta afrenta. A raíz de este conflicto, las autoridades urbanas modifican en diversas ocasiones los criterios de elección de veedores con el fin de acallar las tensiones internas de la corporación, aunque sin mayor éxito. Será nuestro objetivo analizar la naturaleza social de la disputa, para lo cual trataremos de identificar los intereses de los actores en pugna.

This paper aims to analyze the existing tensions within the wool carders' guild of Murcia regarding the annual election of their main authorities – the so-called veedores – from the second half of the fifteenth century to the early sixteenth century. In this period, the guild´s elite sought to monopolize the designation of these authorities, with the resistance of several guild members. As a consequence of this conflict, the local council interceded several times by changing the election system with the aim of calming the tensions, although with no success. Our objective is to identify the interests of the main actors involved in the conflict, in order to analyze the social nature of this dispute.
Les bords de Marne : espaces partagés ou
mondes parallèles
Authors: Levet-Labry Eric
Published: February 2021

Les bords de Marne voient se côtoyer différentes populations qui
entrent en contact, s’ignorent ou vivent dans des mondes parallèles. Ces
différents groupes s’approprient le territoire mais n’en font pas le même usage.
Ces usages touristiques, récréatifs, hédonistes peuvent engendrer des conflits
qui vont opposer les différentes populations d’usagers. Notre recherche va se
limiter à l’étude des usagers des bords de Marne, aux différents usages des
lieux et aux conflits d’usages liés à la pratique d’activités touristiques,
excursionnistes ou récréatives sur les bords de Marne entre Bry-sur-Marne et
Meaux. Il s’agit de rendre compte, à partir d’une enquête, des représentations
qu’ont les usagers, de leur appropriation des lieux et des conflits pouvant
émerger entre les différentes populations et entre les différents adeptes des
loisirs. Les bords de Marne, espaces de rencontre et de confrontation, sont des
espaces partagés, juxtaposés, voire méconnus par la population qui les
fréquente. Les pratiques se côtoient sans (re)connaissance de l’autre. Les
espaces de coprésence deviennent des espaces négociés, partagés ou simplement
des espaces parallèles.
La diversité bioculturelle dans la
tourmente touristique au cœur de l’arrière-pays maya (Mexique)
Authors: Jouault Samuel , Montañez Giustinianovic Alejandro , Xool Koh Manuel
Published: February 2021

L’« arrière-pays maya », contraction de
l’arrière-pays touristique de Cancún-Riviera Maya, est une région située dans la
péninsule du Yucatán au sud-est du Mexique. Depuis les années 1970 et les débuts
de la construction de la ville touristique de Cancún, puis à partir de 1990, la
naissance et l’extension de la Riviera Maya, cette région caractérisée par sa
population d’origine maya et une nature exubérante est marquée par un
développement touristique accéléré. Si dans un premier temps les sites
archéologiques puis les ressources naturelles ont été mis à disposition du
tourisme, aujourd’hui de nombreux acteurs exogènes s’approprient par différents
mécanismes des espaces naturels auparavant aux mains des membres des sociétés
locales. Ici, nous présentons la construction du concept de biodiversité
culturelle, sa signification dans le Yucatán pour les sociétés locales mayas et
sa progressive mise en tourisme, comme les tensions et les conflits qui
augmentent ces dernières années.
Les Patriotes bas-canadiens déportés en 1839. La perception des habitants de la Nouvelle-Galles du Sud*
Authors: Warren Jean-Philippe
Published: February 2021

Le présent texte se penche sur l’accueil donné en la Nouvelle-Galles du Sud aux Patriotes bas-canadiens exilés1. Il est découpé en cinq sections. La première décrit l’impression favorable que firent les détenus bas-canadiens au moment de leur arrivée en Nouvelle-Galles du Sud. La deuxième met en relief comment le statut de prisonnier politique que certains ont voulu leur attribuer a constitué un des principaux facteurs ayant nourri le sentiment de sympathie dont ils furent entourés. Très rapidement, comme le montre la troisième partie, les détenus bas-canadiens ont reçu des appuis importants, non seulement de la part de journalistes et de citoyens gagnés à leur cause, mais aussi de la part de la hiérarchie catholique et des autorités coloniales. La quatrième partie insiste sur les comportements jugés admirables des exilés bas-canadiens pendant leur séjour en terre étrangère. On ne peut donc s’étonner, comme le rappelle la cinquième et dernière section, qu’ils aient obtenu un pardon relativement rapide. Ils étaient, croyait-on, des « détenus exemplaires ». En tout et partout, le présent contribue à l’étude transnationale des Rébellions et, plus généralement, à l’histoire des relations ethniques et politiques à l’échelle de l’Empire britannique.
Lieux en marge et mobilités touristiques. Différencier les lieux ordinaires des lieux à fonctions touristiques régionales
Authors: Piriou Jérôme
Published: February 2021

Dans cet article, nous proposons d’observer les lieux en marge des mobilités touristiques. Les hauts lieux, comme les « non-lieux », ont déjà fait l’objet de recherches diverses. Selon nous, d’autres lieux bénéficient d’une situation touristique. Pourtant ils sont en marge des principaux lieux touristiques. La marge ne s’expliquerait pas par le degré d’intensité de la fréquentation touristique, mais par la spécialisation de pratiques qu’offrent les lieux. Les mobilités touristiques occasionnées pendant un séjour, dans un espace de dimension régionale, permettent la fréquentation de certains lieux plutôt que d’autres. Aussi, au-delà d’une simple différenciation entre lieu ordinaire et lieu touristique, nous cherchons à distinguer les lieux disposant de fonctions touristiques régionales selon la spécialisation des pratiques qu’on y observe. À partir d’une étude menée sur la côte d’Émeraude en Bretagne (France), nous montrons que certains lieux bénéficient d’une proximité géographique avec d’autres lieux touristiques grâce à une mise en relation permise par les mobilités touristiques secondes dans un espace de dimension régionale. Cet article a pour objet de proposer une nouvelle méthode de lecture à partir des concepts existants qui abordent l’attractivité des lieux et les pratiques observées. Une lecture des pratiques spatiales dans une dimension régionale des touristes nous informera de la mise en relation des lieux. Ensuite, en regardant de plus près la motivation de pratique des lieux par les touristes, nous pourrons définir les fonctions récréatives de ces lieux. Enfin, l’analyse de ces fonctions récréatives des lieux facilitera une différenciation entre les lieux ordinaires et les lieux à fonction touristique régionale.
S’approprier la nature : le
développement géographique inégal par le tourisme et l’extraction sur
Anticosti
Authors: Morin Audrey , Lapointe Dominic
Published: February 2021

Les régions périphériques enclavées se retrouveraient souvent
face à d’importants enjeux de développement pour lesquels le tourisme serait
maintes fois évoqué comme solution alternative au développement extractif
traditionnel. Toutefois, un tourisme basé sur les ressources naturelles
serait susceptible de reproduire des logiques similaires à celles de
l’extraction. Cet article propose donc une lecture parallèle des effets
générés par ces deux types de mise en valeur des ressources naturelles sur
l’île d’Anticosti, grâce à la théorie du développement géographique inégal.
Malgré l’abondance des ressources naturelles, la situation géographique de
même que l’historique d’accumulation par dépossession du milieu limiteraient
les capacités d’appropriation de la population locale. En somme, les
résultats démontrent que la mise en tourisme des ressources naturelles de
même que leur extraction transforment toutes deux les usages du territoire
et créent des inégalités par rapport aux retombées économiques produites.
Le défaut d’information et sa difficile compensation en responsabilité civile médicale : quelle place pour le préjudice d’impréparation en droit québécois ?
Authors: Ferron Parayre Audrey
Published: February 2021

Le devoir d’information dû au patient consacre l’importance de l’autonomie de la personne en matière de soins de santé. Si on peut se réjouir de cette consécration, la réparation de l’atteinte aux droits du patient lorsqu’il y a défaut d’information demeure pourtant très difficile au Québec. Les mécanismes de la responsabilité civile médicale actuels font en effet reposer une lourde charge sur les demandeurs. Malgré ces constats, le droit civil québécois ne s’est pas encore attardé à proposer des solutions concrètes pour pallier les difficultés soulevées par la responsabilité civile médicale pour défaut d’information. Ce texte vise ainsi à analyser les enjeux que présente le droit québécois de la responsabilité médicale quant à la réparation du défaut d’information et à discuter des solutions qui pourraient être mises en place, en s’attardant plus spécifiquement au préjudice d’impréparation.
L’émergence des préjudices concurrentiels
Authors: Ménard Benjamin
Published: February 2021

C’est avec la modernité que les préjudices concurrentiels sont apparus. Si le besoin d’en préciser les contours s’est très tôt fait ressentir, ce n’est que récemment que le législateur est intervenu pour prévoir, au sein du Code de commerce, un régime autonome pour certains actes anticoncurrentiels. Cette étude est dès lors l’occasion de revenir sur la manière dont, en droit français, le juge indemnise ces préjudices parfois bien difficiles à appréhender.
Le préjudice esthétique : entre identité et altérité
Authors: Lacroix Mariève
Published: February 2021

Trop souvent confiné dans l’acception normalisante sur laquelle se fonde le recours aux barèmes d’évaluation, le concept de « préjudice esthétique » peut être conçu autrement. Celui-ci allie en effet identité et altérité, puisqu’il ne résulte pas seulement de la transgression du droit à l’intégrité de la victime, mais également de celle d’un faisceau de droits fondamentaux protégés par la Charte québécoise. L’autrice proposera, en ce sens, un traitement novateur du préjudice esthétique et le rapprochera d’une atteinte aux droits à l’honneur, à la vie privée (par l’entremise de sa composante de l’image) ou encore à l’égalité.
Adónde volver
Authors: Kohan Martín
Published: February 2021

El sinsentido de la guerra de Malvinas no se debió a que fuera una guerra que no podía ganarse, sino a que fue una guerra que no convenía ganar (ganarla habría supuesto seguramente una prolongación de la dictadura militar imperante). Esa ausencia de sentido plantea un desafío visceral a las narraciones de la guerra, que se encara de maneras distintas según se trate de narraciones ficcionales o testimoniales.
Solution strategy based on Gaussian mixture models and dispersion reduction for the capacitated centered clustering problem
Authors: Caballero-Morales Santiago-Omar
Published: February 2021

The Capacitated Centered Clustering Problem (CCCP)—a multi-facility location model—is very important within the logistics and supply chain management fields due to its impact on industrial transportation and distribution. However, solving the CCCP is a challenging task due to its computational complexity. In this work, a strategy based on Gaussian mixture models (GMMs) and dispersion reduction is presented to obtain the most likely locations of facilities for sets of client points considering their distribution patterns. Experiments performed on large CCCP instances, and considering updated best-known solutions, led to estimate the performance of the GMMs approach, termed as Dispersion Reduction GMMs, with a mean error gap smaller than 2.6%. This result is more competitive when compared to Variable Neighborhood Search, Simulated Annealing, Genetic Algorithm and CKMeans and faster to achieve when compared to the best-known solutions obtained by Tabu-Search and Clustering Search.
Using algorithmic trading to analyze short term profitability of Bitcoin
Authors: Ahmad Iftikhar , Ahmad Muhammad Ovais , Alqarni Mohammed A. , Almazroi Abdulwahab Ali , Khalil Muhammad Imran Khan
Published: February 2021

Cryptocurrencies such as Bitcoin (BTC) have seen a surge in value in the recent past and appeared as a useful investment opportunity for traders. However, their short term profitability using algorithmic trading strategies remains unanswered. In this work, we focus on the short term profitability of BTC against the euro and the yen for an eight-year period using seven trading algorithms over trading periods of length 15 and 30 days. We use the classical buy and hold (BH) as a benchmark strategy. Rather surprisingly, we found that on average, the yen is more profitable than BTC and the euro; however the answer also depends on the choice of algorithm. Reservation price algorithms result in 7.5% and 10% of average returns over 15 and 30 days respectively which is the highest for all the algorithms for the three assets. For BTC, all algorithms outperform the BH strategy. We also analyze the effect of transaction fee on the profitability of algorithms for BTC and observe that for trading period of length 15 no trading strategy is profitable for BTC. For trading period of length 30, only two strategies are profitable.
COVID-19: exploring impacts of the pandemic and lockdown on mental health of Pakistani students
Authors: Baloch Gul Muhammad , Sundarasen Sheela , Chinna Karuthan , Nurunnabi Mohammad , Kamaludin Kamilah , Khoshaim Heba Bakr , Hossain Syed Far Abid , AlSukayt Areej
Published: February 2021

Background

As of the present, the twenty-first century is experiencing what may be one of its most devastating events, in respect to infected and dead people by the virus. Now known to the world as COVID-19, the devastating disease of what has become a pandemic started its spread from Wuhan, China and swiftly engulfed the whole world with almost 11 million cases, in a span of around six months. It has not only increased the global burden of disease but has heavily dented many social institutions, including education.

Methods

This study investigates how the COVID-19 pandemic and subsequent measures of lockdown, quarantine, and social distancing have affected students. We look specifically into the effects on individuals’ mental health, that is, the stress and anxiety levels of college and university students using the Zung Self-rating Anxiety Scale (SAS).

Results

Among 494 respondents, 61% were females, and the majority (77.3%) of the students were in the age group of 19–25 years. Among the respondents, 125 (25.3%), 45 (9.1%) and 34 (6.9%) experienced minimal to moderate, severe, and most extreme levels of anxiety, respectively. The variables of gender, age and year of study were significant at the 0.25 level by univariate analyses. Nevertheless, the ordinal regression indicates that only gender was significant. The odds of a female student being more anxious are higher compared to a male student (OR = 1.779, 95% CI [1.202–2.634], P = 0.004). The most prominent stressors attained from the qualitative feedback from the Pakistani students are associated with online teaching, concerns about their academic performance and completion of the current semester, uncertainty related to exam dates, and the status of the following semester.

Conclusions

This study will add to the existing body of literature on the impacts of the COVID-19 pandemic on the social and psychological health of students. The study outcomes will provide basic data for further applied and action research and a framework for universities and policy makers in Pakistan and the neighboring countries in the region with the same cultural contexts. Thus, relevant health interventions can be designed for better mental health and educational attainments of students from higher educational institutions. This pathological pandemic may well lead to another pandemic of mental and behavioral illness. All stakeholders should join force regardless of pre-existing differences and inequalities to ensure the well-being of future generations, specifically students from higher educational institutions. The long-lasting impacts and the aftermath of this pandemic will unquestionably need further and future investigations. Keywords: Anxiety, students, mental health, COVID-19, Pakistan
A novel bicyclic 2,4-diaminopyrimidine inhibitor of Streptococcus suis dihydrofolate reductase
Authors: Songsungthong Warangkhana , Prasopporn Sunisa , Bohan Louise , Srimanote Potjanee , Leartsakulpanich Ubolsree , Yongkiettrakul Suganya
Published: February 2021

Streptococcus suis is a Gram-positive bacterial pathogen of pigs and an emerging zoonotic pathogen. It has become increasingly resistant to multiple classes of antibiotics. New drug candidates and knowledge of their targets are needed to combat antibiotic-resistant S. suis. In this study, the open-source Pathogen Box compound library was screened. Thirty hits that effectively inhibited S. suis growth at 10 µM were identified. Among the most potent hits, MMV675968 (a diaminoquinazoline analog) was shown to target S. suis dihydrofolate reductase (SsDHFR) via (1) growth inhibition of an E. coli surrogate whose growth is dependent on exogenously expressed SsDHFR and (2) inhibition of in vitro SsDHFR activity. Thymidine supplement is able to reverse growth inhibition by MMV675968 in both E. coli surrogate and S. suis, indicating that a thymidine-related pathway is a major target of MMV675968. Comparison of MMV675968 with seven DHFR inhibitors representing different core structures revealed that bicyclic 2,4-diaminopyrimidines with long and flexible side chains are highly effective in inhibiting SsDHFR and S. suis growth. MMV675968 and related compounds thus may serve as starting points for developing antibiotics against drug resistant S. suis.
Evaluation of FGFR1 as a diagnostic biomarker for ovarian cancer using TCGA and GEO datasets
Authors: Xiao Huiting , Wang Kun , Li Dan , Wang Ke , Yu Min
Published: February 2021

Background

Malignant ovarian cancer is associated with the highest mortality of all gynecological tumors. Designing therapeutic targets that are specific to OC tissue is important for optimizing OC therapies. This study aims to identify different expression patterns of genes related to FGFR1 and the usefulness of FGFR1 as diagnostic biomarker for OC.

Methods

We collected data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. In the TCGA cohort we analyzed clinical information according to patient characteristics, including age, stage, grade, longest dimension of the tumor and the presence of a residual tumor. GEO data served as a validation set. We obtained data on differentially expressed genes (DEGs) from the two microarray datasets. We then used gene set enrichment analysis (GSEA) to analyze the DEG data in order to identify enriched pathways related to FGFR1.

Results

Differential expression analysis revealed that FGFR1 was significantly downregulated in OC specimens. 303 patients were included in the TCGA cohort. The GEO dataset confirmed these findings using information on 75 Asian patients. The GSE105437 and GSE12470 database highlighted the significant diagnostic value of FGFR1 in identifying OC (AUC = 1, p = 0.0009 and AUC = 0.8256, p = 0.0015 respectively).

Conclusions

Our study examined existing TCGA and GEO datasets for novel factors associated with OC and identified FGFR1 as a potential diagnostic factor. Further investigation is warranted to characterize the role played by FGFR1 in OC.
Effect of Arsenic Toxicity on Chlorophyll Content and Antioxidative Enzymes Activities in Rice Seedlings
Authors: Gaikwad Dinkar J. , Pal Apurba , Mondal Subhasis
Published: February 2021

Aims: Arsenic (As) contamination in rice is at alarming level as majority of rice growing regions in India are As contaminated. Present investigation is designed to study the better understanding of the physiological and biochemical mechanisms in the amount of chlorophyll change and antioxidative enzymes activity under arsenic stress on rice variety IET-4786 (Shatabdi).

Study Design: Completely Randomized Design.

Place and Duration of Study: The experiment was carried out in the departmental laboratory of Plant Physiology, Bidhan Chandra Krishi Viswavidyalaya (BCKV), Mohanpur, Nadia,West Bengal during the year 2017-18.

Methodology: Two classes of inorganic arsenic- As(V) in the form of Sodium arsenate (Na2HAsO4.7H2O, M. W. = 321.01) and As(III) in the form of Sodium arsenite (NaAsO2, M.W. =129.91) were added to the modified Hoagland nutrient solution@ 2.5, 5.0, 7.5, 10.0, 12.5,15.0 mg L-1concentration. After 20 days of treatment, rice seedlings under arsenate/arsenite treatments were analyzed for change in total chlorophyll content and antioxidative enzymes activity such as superoxide dismutase (SOD: EC 1.15.1.1), catalase (CAT: EC 1.11.1.6), ascorbate peroxidase (APX: EC1.11.1.11) and peroxidase (POD: EC 1.11.1.7).

Results: A noticeable decrease in total chlorophyll content was observed with arsenic treatments as compared to control. Various antioxidative enzymes showed significant variable response upon exposure to As(III) and As(V). SOD activities increased at low arsenic exposure up to 7.5 mg L-1 but decreased with further increase in arsenic treatments.  APX and POD activities were increased with increase in arsenic concentrations while CAT activity displayed decreasing trend.

Conclusion: The results are suggestive of differential metabolism of As(III) and As(V) in rice and could exert harmfulness in the early development stage of rice at inappropriate concentrations.
Spatio-Temporal Dynamics of Noon-Time Temperature in Selected Cities in Sudan Savanna and Tropical Rainforest Zones of Nigeria
Authors: Sule I. M. , Nsofor G. N. , Okhimamhe A. A. , Mayaki J. , Muhammed M.
Published: February 2021

Urban centres in Sub-Saharan Africa have been undergoing unprecedented urbanization in the past decades at annual rates of almost 4%; with attendant impacts on the cities’ thermal conditions. This study aimed at characterizing the noon-time maximum temperature of two selected cities each in the Sudan and Tropical Rainforest zones of Nigeria. The study utilized daily ERA Interim (European Reanalysis) grid-based 2 meter above ground daily noontime maximum temperature (°C) data of the European Centre for Medium-range Weather Forecasts (ECMWF) from 1990 to 2019. R Statistical package version 3.6.1 was employed to detect the trend and seasonality in the maximum noon-time temperature of the four cities using non-parametric Mann-Kendall trend and seasonal trend tests. The statistical properties of the data were first analyzed by graphical examination of the data, using time plots, and boxplots. Also, the normality test of Shapiro-Wilk (S-W test) was applied. Pettitt test was then employed to test for single change-point detection in the temperature series. The study revealed higher mean temperature values of 27.49°C and 25.56°C respectively for Birnin Kebbi and Kano both in the Sudan, and lower temperature values of 24.08°C and 23.17°C respectively for Ibadan and Owerri located in the Tropical rainforest. The Tau statistics for Kano, Ibadan and Owerri are 0.07084, 0.09848 and 0.09113 and the corresponding p-values are 0.0447, 0.0053 and 0.0098 which are less than 0.05 alpha value; indicating significant trends for the three cities. The results also show significant seasonal increase at 0.05 significant levels in the maximum noon-time temperature series for all the locations. The study recommends urban landscape planning and design for optimization of outdoor thermal comfort and creation of heathier urban environments for the city dwellers.
The Effect of Balance Training in Knee Osteoarthritis
Authors: Elsheikh Marwa Mohamed Alawady , El-Hawa Marwa Ahmed Abo , El-saadany Hanan Mohamed , Elsergany Mervat Abd El Sattar
Published: February 2021

Background: Osteoarthritis (OA) is the most common chronic disease that affects joints; especially knee joints. OA causes progressive irreversible joint damage and finally joint failure. Proprioceptive deficits are greater in people with knee OA.

Objective: The aim of this study is to assess and evaluate the effect of balance training as an additional modality in management of mild and moderate knee osteoarthritis and its effect on clinical and functional outcome.

Methods: The study included 60 patients with primary knee osteoarthritis, consecutively selected from outpatient clinic of Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Tanta University Hospitals. They were divided into two groups: Group I:  (30) Patients was trained by strength exercises rehabilitation program in addition to training program of the BSS-SD. Three sessions per week for twelve weeks. Group II: (30) Patients were trained by strength exercises rehabilitation program only by three sessions per week for twelve weeks. Patients were assessed by clinical evaluation (visual analogue scale (VAS), Ritchie's tenderness scale, morning stiffness, range of motion) physical performance assessments by chair stand test, functional assessment by WOMAC, assessment of postural stability and balance disturbance (postural stability test- fall risk test- limits of stability test) were performed before, 6 and 12 weeks after rehabilitation programs

Results: Our study showed improvement in both groups of clinical assessment (VAS of pain, tenderness, morning stiffness) also there was significant improvement of (active range of movement and passive range of movement and CST). There was significant improvement of pain assessed by WOMAC. There was significant improvement of (postural stability test, fall risk testing, and limits of stability).  There were improvement in-group I more significant than group II.

Conclusion: Combined therapy of strength exercises rehabilitation program and training program of balance by BSS-SD have more potential effects in treatment of mild and moderate knee OA better than strength exercises rehabilitation program only.