bluuebunny/crossref_metadata_2025 huggingface dataset:
Discretization and machine learning approximation of BSDEs with a constraint on the Gains-process
Authors: Kharroubi Idris , Lim Thomas , Warin Xavier
Published: January 2021

We study the approximation of backward stochastic differential equations (BSDEs for short) with a constraint on the gains process. We first discretize the constraint by applying a so-called facelift operator at times of a grid. We show that this discretely constrained BSDE converges to the continuously constrained one as the mesh grid converges to zero. We then focus on the approximation of the discretely constrained BSDE. For that we adopt a machine learning approach. We show that the facelift can be approximated by an optimization problem over a class of neural networks under constraints on the neural network and its derivative. We then derive an algorithm converging to the discretely constrained BSDE as the number of neurons goes to infinity. We end by numerical experiments.
Rare squamous cell carcinoma of the kidney with concurrent xanthogranulomatous pyelonephritis: A case report and review of the literature
Authors: Chang Tsung-Hsin , Tseng Jen-Shu
Published: January 2021

Case presentation

In the current study, we report a 69-year-old female patient who was initially diagnosed with xanthogranulomatous pyelonephritis (XGPN) with nephrolithiasis and a peri-renal abscess. She presented to our department with right flank pain. Physical examination revealed right costovertebral angle knocking pain and computed tomography revealed dilated calyces and one staghorn stone over right kidney, with multiple abscess accumulations over the right peri-renal region. Right radical nephrectomy was performed using a transperitoneal flank approach, and pathology revealed squamous cell carcinoma (SCC) with concurrent XGPN. The patient was alive at 4 months post-operative follow-up. To the best of our knowledge, this is only the fifth case of renal SCC with concurrent XGPN reported in the English medical literature.

Conclusion

Renal SCC with coexisting XGPN is an extremely rare presentation and only four cases have been previously reported in the English medical literature. A positive diagnosis for this rare combination of diseases was established, based on pathological and immunohistochemical examinations after radical nephrectomy. Poor prognosis has been reported in such cases. Malignancies should be considered in patients with a long-standing history of urolithiasis.
COVID-19 vaccine: Call for employees in international transportation industries and international travelers as the first priority in global distribution
Authors: Yu Zhuo , Wang Gang , Goldman Emanuel , Zangerl Barbara , Xie Ning , Cao Yanhong , Chen Jingyu , Day Sara W. , Howard Scott C. , Maida Marcello , Ray Kunal , Jablonski Monica M. , Ji Jiafu , Postlethwaite Arnold , Gu Weikuan , Sun Dianjun , Aleya Lotfi
Published: January 2021

While countries are in a hurry to obtain SARS-CoV-2 vaccine, we are concerned with the availability of vaccine and whether a vaccine will be available to all in need. We predicted three possible scenarios for vaccine distributions and urge an international united action on the worldwide equitable access. In case the international community does not reach a consensus on how to distribute the vaccine to achieve worldwide equitable access, we call for a distribution plan that includes the employees in international transportation industries and international travelers to halt the disease transmission and promote the recovery of the global economy.
Polymerization mechanisms initiated by spatio-temporally confined light
Authors: Skliutas Edvinas , Lebedevaite Migle , Kabouraki Elmina , Baldacchini Tommaso , Ostrauskaite Jolita , Vamvakaki Maria , Farsari Maria , Juodkazis Saulius , Malinauskas Mangirdas
Published: January 2021

Ultrafast laser 3D lithography based on non-linear light–matter interactions, widely known as multi-photon lithography (MPL), offers unrivaled precision rapid prototyping and flexible additive manufacturing options. 3D printing equipment based on MPL is already commercially available, yet there is still no comprehensive understanding of factors determining spatial resolution, accuracy, fabrication throughput, repeatability, and standardized metrology methods for the accurate characterization of the produced 3D objects and their functionalities. The photoexcitation mechanisms, spatial-control or photo-modified volumes, and the variety of processable materials are topics actively investigated. The complexity of the research field is underlined by a limited understanding and fragmented knowledge of light-excitation and material response. Research to date has only provided case-specific findings on photoexcitation, chemical modification, and material characterization of the experimental data. In this review, we aim to provide a consistent and comprehensive summary of the existing literature on photopolymerization mechanisms under highly confined spatial and temporal conditions, where, besides the excitation and cross-linking, parameters such as diffusion, temperature accumulation, and the finite amount of monomer molecules start to become of critical importance. Key parameters such as photoexcitation, polymerization kinetics, and the properties of the additively manufactured materials at the nanoscale in 3D are examined, whereas, the perspectives for future research and as well as emerging applications are outlined.
Crystal structure of catena-poly[trans-tetraaqua(μ2-1,1′-(biphenyl-4,4′-diyl)bis(1H-imidazol)-k2N:N′)cobalt(II)] dinitrate – 1,1′-(biphenyl-4,4′-diyl)bis(1H-imidazol) – water (1/3/2), C72H68CoN18O12
Authors: Li Huixing , Han Xinlong , Cao Bin
Published: January 2021

C72H68CoN18O12, triclinic,

P

1
‾

$P‾{1}$

(no. 2), a = 9.2801(10) Å, b = 11.6017(11) Å, c = 16.4968(15) Å, α = 96.294(8)°, β = 96.371(8)°, γ = 105.025(9)°, V = 1687.0(3) Å3, Z = 1, R

gt
(F) = 0.0631, wR

ref
(F
2) = 0.1043, T = 293(2) K.
Crystal structure of bis(μ2-2-oxido-2-phenylacetate-κ3
O:O,O′)-bis(1-isopropoxy-2-oxo-2-phenylethan-1-olato-κ2O,O′)-bis(propan-2-olato-κ1O)dititanium(IV), C44H52O14Ti2
Authors: Youzhu Yu , Yuhua Guo , Yongsheng Niu , Nana Liu , Hongfei Zhang
Published: January 2021

C44H52O14Ti2, orthorhombic, Pbca (no. 61), a = 15.0005(7) Å, b = 15.9478(8) Å, c = 18.4438(10) Å, V = 4412.2(4) Å3, Z = 4, R
gt(F) = 0.0372, wR
ref(F
2) = 0.1089, T = 296(2) K.
Crystal structure of [(μ2-succinato κ3
O,O′:O′′)-bis-(5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane)]dinickel(II)] diperchlorate, dihydrate C36H82Cl2N8Ni2O15
Authors: Li Wen-Yi , Ou Guang-Chuan
Published: January 2021

C36H82Cl2N8Ni2O15, monoclinic, P21/n (no. 14), a = 17.657(3) Å, b = 16.047(3) Å, c = 18.346(3) Å, β = 109.062(4)°, V = 4913.2(16) Å3, Z = 4, R

gt
(F) = 0.0561, wR

ref
(F
2) = 0.1664, T = 173(2) K.
Crystal structure of tetrakis(μ-naphthalene-1-carboxylato-κ
2
O,O′)bis(methanol)copper(II), C46H36Cu2O10
Authors: Shi Li‐Qin
Published: January 2021

C46H36Cu2O10, monoclinic, C2/c (no. 15), a = 32.663(7) Å, b = 7.4214(15) Å, c = 21.785(4) Å, β = 131.68(3)°, V = 3944.0(19) Å3, Z = 4, R

gt
(F) = 0.0478, wRref
(F
2) = 0.1583, T = 295 K.
Mitochondria and traffic-related air pollution linked coronary artery calcification: exploring the missing link
Authors: Sivakumar Bhavana , Kurian Gino A.
Published: January 2021

The continuing increase in the exposure to Traffic-related air pollution (TRAP) in the general population is predicted to result in a higher incidence of non-communicable diseases like cardiovascular disease. The chronic exposure of air particulate matter from TRAP upon the vascular system leads to the enhancement of deposition of calcium in the vasculature leading to coronary artery calcification (CAC), triggered by inflammatory reactions and endothelial dysfunction. This calcification forms within the intimal and medial layers of vasculature and the underlying mechanism that connects the trigger from TRAP is not well explored. Several local and systemic factors participate in this active process including inflammatory response, hyperlipidemia, presence of self-programmed death bodies and high calcium-phosphate concentrations. These factors along with the loss of molecules that inhibit calcification and circulating nucleation complexes influence the development of calcification in the vasculature. The loss of defense to prevent osteogenic transition linked to micro organelle dysfunction that includes deteriorated mitochondria, elevated mitochondrial oxidative stress, and defective mitophagy. In this review, we examine the contributory role of mitochondria involved in the mechanism of TRAP linked CAC development. Further we examine whether TRAP is an inducer or trigger for the enhanced progression of CAC.
A review on TiO2-based composites for superior photocatalytic activity
Authors: Al Zoubi Wail , Salih Al-Hamdani Abbas Ali , Sunghun Baek , Ko Young Gun
Published: January 2021

Heterogeneous photocatalysts was a promising material for removing organic pollutants. Titanium dioxide (TiO2) was a suitable photocatalyst for its cost efficiency and high stability to reduce various pollutants. Enhancing TiO2 photocatalyst performance by doping with changed metals or non-metal ions and organic compounds have been reviewed. These methods could enhance photoelectrochemical activity via: (i) by a donor of electrons via electron-donor agents that would produce particular defects in TiO2 structure and capture transporters of charge; (ii) by reducing recombination rate of the charge transporters and increasing degradation of pollutants. This study investigates the modification approaches of TiO2 that comprise methods for overcoming the essential TiO2 restrictions and enhancing the photocatalytic degradation of organic pollutants. Consequently, it emphasized on the current progress of modified-TiO2 used for different pollutants in ambient conditions. Amendment techniques, such as inorganic and organic parts as doping, are studied. The reported experimental results obtained with the photocatalytic oxidation process for degrading organic pollutants were also collected and assessed.
External Peer Challenge in Local Government: The Role of Spatial Spillover and Past Performance
Authors: Jäkel Tim
Published: January 2021

Voluntary assessments by a team of critical friends (external peer challenges) among local governments became established as popular complement to compulsory and centralized audits and inspections. This study empirically investigates the decision of English local authorities to have a voluntary peer challenge or not by taking advantage of an original dataset about participation in the Local Government Association’s Peer Challenge Programme (CPC) 2010–2015. We find that the LGA’s CPC programme does not carry a risk of leaving behind authorities with performance shortcomings. Councils with poor past performance scores and those with excellent ones do not differ in their tendency to invite a team of critical friends. Spatial clusters exist in the case of small district councils but not in the case of larger unitary authorities, London boroughs and metropolitan authorities. This implies that the corporate peer challenge process seems to be more suited to small authorities delivering community based services.
Automation of extra-analytical phase for clinical laboratory
Authors: Bakan Ebubekir , Umudum Fatma Zuhal
Published: January 2021

Extra-analytical automation is of critical importance in patient safety with respect to accurate, fast test result reporting. Through the previous decades, significant improvements in laboratory errors have been achieved by technological facilities, which have become a substantial part of the reduction of preventable diagnostic errors. In clinical laboratory practice, the total testing process (TTP) is under the effect of error sources: preanalytical, analytical, and post-analytical variables. Since many extra-analytical processes within and outside the clinical laboratory may be automated, management of the extra-analytical phase can prevent errors, resulting in the total quality of laboratory diagnostics and customer satisfaction. The automation technologies have added a serious impact on the proficiency of clinical laboratories. To improve standardization, organization, efficiency, and quality of TTP, many manual tasks have now been partially or entirely automated by labor-saving instrumentations. The implementation of extra-analytical automation in the laboratory processes has recently made them standardized and manageable. Depending on the workload and workflow of the clinical laboratory, it is of critical importance to implement adequate systems, providing standardization of the TTP and resulting in high-quality test results.
IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma
Authors: Yang Ying , Wang Jin , Xu Shihai , Lv Wen , Shi Fei , Shan Aijun
Published: January 2021

Background

In cancer, kappa B-interacting protein (IKBIP) has rarely been reported. This study aimed at investigating its expression pattern and biological function in brain glioma at the transcriptional level.

Methods

We selected 301 glioma patients with microarray data from CGGA database and 697 glioma patients with RNAseq data from TCGA database. Transcriptional data and clinical data of 998 samples were analyzed. Statistical analysis and figure generating were performed with R language.

Results

We found that IKBIP expression showed positive correlation with WHO grade of glioma. IKBIP was increased in isocitrate dehydrogenase (IDH) wild type and mesenchymal molecular subtype of glioma. Gene ontology analysis demonstrated that IKBIP was profoundly associated with extracellular matrix organization, cell–substrate adhesion and response to wounding in both pan-glioma and glioblastoma. Subsequent gene set enrichment analysis revealed that IKBIP was particularly correlated with epithelial-to-mesenchymal transition (EMT). To further elucidate the relationship between IKBIP and EMT, we performed gene set variation analysis to screen the EMT-related signaling pathways and found that IKBIP expression was significantly associated with PI3K/AKT, hypoxia and TGF-β pathway. Moreover, IKBIP expression was found to be synergistic with key biomarkers of EMT, especially with N-cadherin, vimentin, snail, slug and TWIST1. Finally, higher IKBIP indicated significantly shorter survival for glioma patients.

Conclusions

IKBIP was associated with more aggressive phenotypes of gliomas. Furthermore, IKBIP was significantly involved in EMT and could serve as an independent prognosticator in glioma.
Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway
Authors: Fu Kong , Chen Miancong , Zheng Hua , Li Chuanzi , Yang Fan , Niu Qian
Published: January 2021

Background

Morbidity and mortality remain high for ischemic stroke victims, and at present these patients lack effective neuroprotective agents, which improve the cure rate. In recent years, studies have shown that pelargonidin has many biological actions. However, few studies are available regarding the pelargonidin treatment of cerebral ischemia.

Methods

The rat middle cerebral artery occlusion (MCAO) model was established to investigate the neuroprotective effect of pelargonidin on cerebral ischemia/reperfusion injury. Reperfusion was performed 2 h after ischemia; magnetic resonance imaging (MRI) and 2, 3, 5-triphenyltetrazolium chloride (TTC) staining were used to measure the volume of cerebral ischemia. Both modified neurological severity scores (mNSSs) and Morris water maze test were used to assess the neurological functions. ELISA was applied to determine the levels of TNF-α, TGF-β, IL-6, IL-10, MDA, and SOD. The expression of Nuclear factor-E2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) protein in brain tissue was measured by immunofluorescence and Western blot assays.

Results

The results showed that pelargonidin could effectively reduce the volume of cerebral ischemia and improve the neurological function in MCAO rats, thereby improving memory and learning ability. With the corresponding decreases in the expression of TNF-α, TGF-β, IL-6, and MDA, the level of IL-10 and SOD increased and also promoted the nuclear metastasis of Nrf2 and the expression of HO-1 in ischemic brain tissues.

Conclusions

Our data demonstrated that pelargonidin ameliorated neurological function deficits in MCAO rats, and its potential mechanism of action was associated with overexpression of the Nrf2/HO-1-signaling pathway. This study will provide a new approach to treat cerebral ischemia/reperfusion injury.
Byzantine Monasticism on the Black Mountain West of Antioch in the 10th-11th Centuries
Authors: Glynias Joe
Published: January 2021

This article sheds light on a hitherto unexplored phenomenon that alters our picture of Byzantine monasticism: the monastic culture of the Black Mountain outside Antioch. From 969-1084, the Black Mountain thrived as a destination for a variety of Chalcedonian monks: Greek-speaking Romans, Arabic-speaking Melkites, Georgians, and Armenians. I illustrate the prosperity of monastic life on the Black Mountain, the scholarly activity flourishing in and between languages, and the networks connecting the mountain to monasteries inside and outside of Byzantium.

In this paper, I examine three bodies of source material: manuscripts produced at the Black Mountain, texts produced by its scholars, and the letters of Nikon of the Black Mountain. Colophons in Greek, Arabic, Syriac, and Georgian manuscripts display the active scribal culture of these monasteries. Scholars centered at St. Symeon produced scores of translations from Greek into Arabic and Georgian that illustrate the lasting impact of this multilingual intellectual atmosphere. Nikon’s letters provide the basis for a cultural history of Antiochene monasticism. From these and other sources, I show that the Black Mountain was a major hub in middle Byzantine monastic networks. At the same time when Athos was assuming a primary role in the western Orthodox monastic world, the Black Mountain was performing a similar function in the east.
Alexander’s Comrades in the Chronicle of John Malalas
Authors: Garstad Benjamin
Published: January 2021

As a rule in the historical tradition, over time the larger cast of characters behind a series of events, the king and his court, is distilled down to the person of a single actor, the king, while his ministers and lieutenants are consigned to oblivion. Alexander the Great is by and large an exception to this rule. His Companions play important roles in his reign and campaigns, his character is developed to a great extent in his relations with them, and they rise to prominence in their own right as his successors; they form an indispensable part of the memory of Alexander. This is certainly true of the account of Alexander in the Chronographia of John Malalas, the seminal work of the Byzantine chronicle tradition. The men surrounding Alexander are referred to repeatedly, in marked contrast to the other historical personages who feature in the Chronographia. The terms that Malalas uses of Alexander’s Companions, however, are unusual, and require some interpretation. And the prominence of his Companions in this narrative seems intended to contribute to an essentially, but subtly negative depiction of Alexander by recalling the most disreputable incidents in Alexander’s career, which usually involved his Companions.
Wisdom Class Learning Task Design
Authors: Dai Daxiang
Published: January 2021

The learning task is the core of learning design and also an essential part of classroom teaching. Classroom teaching is composed of various learning tasks. Therefore, it is significant to design the learning task to help students learn through accumulation, which is also the key factor of establishing a smart classroom. Simultaneously, the learning task also works as the in-service teachers’ framework in the primary and secondary schools to design and evaluate the learning tasks. This paper designs four types of learning tasks, including discovery, selective, inductive, and evaluating. As a result, to provide a reference for primary and secondary school teachers to further design and evaluate learning tasks.
Micro-class Task Design
Authors: Hu Yegong
Published: January 2021

The concept of wisdom education emphasizes the generation of students’ wisdom, which happens in teaching practice. Teachers arouse the original thoughts and knowledge base. Then students start the learning process of conception, discovery, choice, induction, and evaluation, and as a result, achieve the ability enhancement of creative thinking ability and problem-solving. Under the guidance of wisdom education, the micro-course design ought to effectively promote students’ experience in one or several stages of the intelligent learning process. It is suggested that students’ participate in and complete specific tasks to encourage students to experience the entire learning process. This article used various case explanation, mainly discussed how to design smart micro-course tasks that promote students’ wisdom generation and develop students’ thinking.
Application and Empirical Study of Educational Informationization
Authors: Gao Fei
Published: January 2021

With the steady development and growth of economic society, remarkable achievements have been made in the construction and application of teaching resources, the establishment, and development of teaching staff, the innovation of the teaching and learning model, and the in-depth application of information and communication technology. In particular, is the thriving education undertaking? At the time local governments accelerating economic and social development, education is always the priority. They took education informatization as an essential solution to improve education development, promoting education informatization. This article takes Chengchuan Elementary School as an example, introduced the balanced development of urban and rural education and the cooperation with universities, and summarized its practical experience in applying education informatization under local conditions.
Research on Micro-class Resources in the PBL Model
Authors: Li Xiaoyu
Published: January 2021

The problem-based learning method (PBL) is a problem-centered method based on the student-oriented practical educational mode. Under the teachers’ guidance, PBL calls for the mode of “student-centered and problem-based,” in the form of group discussions, enabling students to independently collect information concentrated on a particular issue, discover and solve problems. As a result, it is essential to cultivate students’ independent learning ability and innovation abilities. This teaching model focuses on cultivating students’ thinking ability and problem-solving abilities. Therefore, it has gained popularity among the majority of education researchers. Its application in wisdom teaching practice is still insufficient, and the advantages of micro-course resources can solve some of these problems. Therefore, this research combines “micro-class” and “PBL” to explore the application method of micro-class resources in the PBL model to promote the generation of students’ wisdom.
Itikad Baik Dalam Perjanjian Suatu Perspektif Hukum Dan Keadilan
Authors: Suprapti Endang , Tarigan Arihta Esther
Published: January 2021

Contract or agreement is a first step in carrying out a fulfillment of needs and interests so humans are always in touch with each other in various places and times with various events.How good faith becomes the basis for parties to make an agreement. To answer this problem, research sources in the form of primary legal materials are needed, both in the form of laws and regulations, court decisions and secondary sources in the form of books, texts, legal dictionaries, legal journals. The research method in this paper uses primary and secondary legal materials, the law approach and conceptual approach. This type of research is normative and qualitative in nature.Keywords: Good faith, Agreement, Justice AbstrakKontrak atau perjanjian adalah suatu langkah awal dalam menyelenggarakan suatu pemenuhan kebutuhan dan kepentingan maka manusia selalu berhubungan satu sama lain di berbagai tempat dan waktu dengan berbagai macam peristiwa. Bagaimana itikad baik menjadi dasar bagi pihak  dalam membuat suatu perjanjian. Untuk menjawab permasalahan ini diperlukan sumber penelitian berupa bahan hukum primer, baik berupa peraturan perundang-undangan, putusan pengadilan dan sumber sekunder berupa buku-buku, teks, kamus-kamus hukum, jurnal hukum. Metode penelitian dalam penulisan ini menggunakan bahan hukum primer dan sekunder, pendekatan undang-undang dan pendekatan konseptual. Jenis Penelitian ini adalah Normatif dan bersifat kualitatif.Kata Kunci: Itikad Baik, Perjanjian, Keadilan
Etika Bisnis Unit Usaha Pesantren (Studi Kasus Pondok Pesantren Sahid Bogor dan Pondok Pesantren Ummul Qura’ Al-Islami Bogor)
Authors: Cahyo Dwi Irfan
Published: January 2021

AbstractEthics in Islamic business cannot be separated, because without it there will be confusion in determining the truth in doing business and there will be many crimes in business, thus the purpose of this study is to determine the application of business ethics in the pesantren business unit. The research methodology used is qualitative descriptive with a case study of the Sahid Bogor modern Islamic boarding school and also the Ummul Qura al-Islami Islamic boarding school in Bogor. The results of the study indicate that Islamic boarding school is able to apply business ethics through Islamic boarding school business unit as a place for Islamic teaching values and values as well as the principles of business ethics as materials that can be taught to teacher, student and the community around Islamic boarding school.Key words: Islamic business ethics, business units, Islamic boarding school AbstrakEtika dalam bisnis Islam tidak dapat terpisahkan, karena tanpanya akan menjadikan kerancuan dalam menentukan kebenaran dalam berbisnis serta akan terjadi banyak kejahatan dalam bisnis. Dengan begitu tujuan penelitian ini adalah untuk mengetahui penerapan etika bisnis pada unit usaha pesantren. Metodologi penelitian yang digunakan berupa kualitatif deskriptif dengan studi kasus pondok pesantren modern Sahid Bogor dan juga pondok pesantren Ummul Qura al-Islami Bogor. Hasil dari penelitian menunjukkan bahwa pesantren mampu menerapkan etika bisnis melalui unit usaha pesantren sebagai wadah dan nilai ajaran Islam serta prinsip etika bisnis sebagai bahan yang dapat diajarkan kepada asatidz dan santri serta masyarakat sekitar pesantren.Kata kunci: Etika bisnis Islam, Unit usaha, Pesantren
Az allogén vérképző őssejtátültetés korai szövődményei gyermekkorban
Authors: Horváth Orsolya , Nyirő Judit , Kállay Krisztián , Mező Blanka , Kassa Csaba , Hau Lídia , Kertész Gabriella , Horváth Máté , Sinkó János , Prohászka Zoltán , Kriván Gergely
Published: January 2021

Absztrakt:

Bevezetés: Az allogén vérképző őssejt-transzplantáció (tx)
indikációja gyermekkorban a magas szövődményráta és a nem elhanyagolható
halálozás miatt csak az életet veszélyeztető betegségekre korlátozódik. A
csökkentett toxicitású kondícionáló kezelések bevezetése után célul tűztük ki az
egyes a transzplantációs szövődmények, mint graft-versus-host betegség (GVHD),
vírusreaktiváció és transzplantációhoz társult thromboticus microangiopathia
(TA-TMA) időbeli és egymáshoz viszonyított előfordulásának és a különböző
kondícionáló kezelések és a fenti transzplantációs szövődmények összefüggéseinek
feltárását. Betegek és módszer: Prospektíven száz (8,5 ± 4,9
év) gyermeket vizsgáltunk, akik malignus (n = 54) és nem
malignus alapbetegség (n = 46) miatt részesültek allogén
tx-ban. A kondícionáló kezelés megkezdésétől monitoroztuk a korai szövődmények,
így az akut GVHD, a vírusreaktivációk, a TA-TMA felléptét, illetve relapszus
jelentkezését. Eredmények: A gyerekek kétharmadánál (67%)
észleltünk legalább egy korai szövődményt a felsoroltak közül. A leggyakoribb
transzplantációs szövődmény a vírusreaktiváció volt (50%). Akut GVHD a betegek
26%-ánál, a medián 31. (10.–174.) napon alakult ki. Az akut GVHD-s esetek 27%-a
(7/26) zajlott súlyos (Grade III–IV) formában. A TA-TMA döntően enyhe volt,
kizárólag ciclosporin adása során, más transzplantációs szövődményekhez
társultan jelentkezett. A TA-TMA kialakulását 5/20 esetben GVHD, 5/20 esetben
vírusreaktiváció, és 4/20 esetben vírusreaktiváció és GVHD is megelőzte. A
súlyos szövődmények alacsony számával ellentétben a relapszusráta (22/54; 41%)
magas volt. A vizsgált betegcsoport összesített túlélése medián 3,8 (1,3–6,5) év
követési idő múltán 74%. A nem malignus betegség miatt transzplantált gyermekek
összesített túlélése kiváló (43/46; 93,5%). Ezzel szemben a malignus csoportban
a halálozási arány – a magas relapszusrátának megfelelően – (17/54, 31,5%)
magas. Következtetés: A csökkentett toxicitású kondícionáló
kezelések bevezetése óta a súlyos korai transzplantációs szövődmények száma
alacsony. A TA-TMA döntően enyhe formában, vírusreaktivációhoz vagy GVHD-hoz
társultan jelentkezett. A malignus alapbetegség esetén a halálozás fő oka a
relapszusok magas száma.
T. J. Kasperbauer, Subhuman: The Moral Psychology of Human Attitudes to Animals
Authors: Mandrioli Mauro
Published: January 2021

T. J. Kasperbauer, Subhuman: The Moral Psychology of Human Attitudes to Animals (Oxford: Oxford University Press, 2018), 248 pp. ISBN: 978-0-19069-581-1. £25.49 (hbk).
Why Alex Rosenberg — and a Number of Other Philosophers — Are Wrong Just about Everything
Authors: Pigliucci Massimo
Published: January 2021

There is a pernicious tendency these days among some philosophers to engage in a “nothing but” attitude about important questions. According to this attitude, consciousness, volition, reason, and morality are “illusions,” “nothing but” the epiphenomena of specific neural processes. Alex Rosenberg is a particularly good (though by no means the only) illustration of this problem, which is why his work is presented and analyzed in some detail in this contribution. The general attitude displayed by Rosenberg et al. falls squarely under the rubric of “scientism,” the notion that science (however vaguely and very broadly defined) is the only reliable source of knowledge and understanding, and that all other disciplines (especially the humanistic ones) ought to bow to its dictates. The results are, predictably, incoherent and pernicious, as it is illustrated here via a number of examples.
Darryl Jones, Sleeping with the Lights On
Authors: Clasen Mathias
Published: January 2021

Darryl Jones, Sleeping with the Lights On: The Unsettling Story of Horror (Oxford: Oxford University Press, 2018), xii + 181 pp. £10.99/$16.95. ISBN

978-0-19882-648-4.
Michael J. Kelly and Arthur Rose (eds), Theories of History: History Read across the Humanities
Authors: Retz Tyson
Published: January 2021

Michael J. Kelly and Arthur Rose (eds), Theories of History: History Read across the Humanities (London and New York: Bloomsbury, 2018), 264 pp. ISBN: 9-781-47427-132-5. £102.60 (hbk); £35.96 (pbk).
Adrian Currie, Rock, Bone and Ruin: An Optimist’s Guide to the Historical Sciences
Authors: Padian Kevin
Published: January 2021

Adrian Currie, Rock, Bone and Ruin: An Optimist’s Guide to the Historical Sciences (Cambridge, MA: MIT Press, 2018), ix + 372 pp. ISBN: 9-780-26203-726-6. $35 (hbk).
BIOESTATÍSTICA: PORQUE, O QUE É COMO ENSINAR
Authors: Peixoto Maurício A. P.
Published: January 2021

Resumo: Apresentamos uma forma diferente de ensinar Estatística para estudantes de pós-graduação. Acreditamos haver duas causas principais para o conhecido "trauma matemático": a) falta base Matemática e b) o estudante sente-se incapaz de entender a linguagem estatística. Construímos, baseando-nos nessas causas, um curso introdutório com duas características marcantes: a) quando necessário, e antes de cada novo conceito estatístico, apresentam-se os tópicos matemáticos pertinentes e b) apresenta-se a lógica da linguagem matemática, através de sua explicitação no tema em discussão. Este sistema foi testado em 25 estudantes de pós-graduação, submetidos a um pré-teste, repetido após como prova final. Naquela época responderam, também, a um questionário anônimo de avaliação do curso e do professor. Os resultados demonstraram que não só os alunos gostaram do curso como, também, puderam aprender Estatística. É difícil medir a validade externa desse método. Acreditamos, no entanto, que se aplicado com seriedade, em contexto similar, poderá trazer bons resultados.
DA MEDICINA PREVENTIVA A MEDICINA COMUNITARIA: PROCESSO DE CONSTITUIÇÃO DE CAMPO DE ENSINO EXTRAMUROS NA FACULDADE DE MEDICINA DE BOTUCATU - UNESP (1969 - 1973)
Authors: Cyrino Antonio Pithon
Published: January 2021

Resumo: Estuda-se a experiência realizada na Faculdade de Medicina de Botucatu - UNESP, através do Departamento de Medicina Preventiva (DMP), ao constituir um novo espaço à educação médica: junto à comunidade. A investigação foi produzida através da análise de documentos e entrevistas com docentes do DMP. Identificou-se uma reorientação na constituição dos campos de ensino extramuros e prática em saúde ao incorporarem os pressupostos da Medicina Comunitária aos inicialmente adotados da Medicina Preventiva. Tal deslocamento é reconhecido pelas especificidades dos serviços de saúde organizados para tanto. Em 1970, instalou-se a “Unidade Sanitária do Lageado”: sob influência do ideário da Medicina Preventiva expresso nos objetivos de consecução de uma prática voltada à formação de atitudes e de uma consciência preventiva nos futuros profissionais. A constituição do Centro de Saúde Escola, em 1972, sob inspiração da Medicina Comunitária, imprimiu uma nova orientação a experiência anterior ao deslocar-se do ensino para a elaboração de um projeto técnico-assistencial.
Realidade ou simulação? Análise do desempenho de estudantes de Medicina em avaliações práticas distintas
Authors: Cassiano Matheus Santarosa , Passeri Silvia Maria Riceto Ronchim , Lutaif Nelson Afonso
Published: January 2021

Resumo: Introdução: Avaliar habilidades clínicas é um desafio no curso médico. A heterogeneidade na escolha dos pacientes somada à falta de critérios objetivos resultou em mudança metodológica para utilização do Objective Structured Clinical Examination (OSCE). Objetivo: O objetivo deste estudo foi identificar se o OSCE resulta em distribuição de frequência de notas de desempenho de padrão gaussiano em comparação ao modelo tradicional. Método: Analisaram-se as notas de 239 estudantes da disciplina de Semiologia e Propedêutica de um curso de Medicina entre 2016 (modelo tradicional) e 2017 (OSCE) pelos testesKolmogorov-Smirnovbidimensional e t de Student para verificar a correlação delas com o coeficiente de rendimento (CR). Resultados: As notas da prova no modelo tradicional (p < 0,0001; KS = 0,1881) estão mais distantes da normalidade do que as da prova do modelo OSCE (p = 0,0010; KS = 0,1134) e são mais correlatas com o CR (p < 0,0001; r = 0,45) do que no modelo OSCE (p = 0,31; r = 0,06). Conclusão: O OSCE pode proporcionar informações mais fidedignas sobre o desempenho do estudante em estágios práticos do curso médico.
Fluxo do esgotamento: interrogando o processo de produção do tempo/cansaço no internato médico
Authors: Oliveira Suellen Magalhães Dias , Hasse Mariana , Teixeira Flávia do Bonsucesso
Published: January 2021

Resumo: Introdução: A síndrome de burnout causa repercussão com impactos individuais, sociais e econômicos. A tríade que representa a síndrome acomete milhões de trabalhadores pelo mundo, incluindo os trabalhadores da área da saúde e, entre eles, os médicos. Pesquisas apontam um incremento das taxas de burnout entre médicos e residentes, mas pouco se fala sobre a síndrome em estudantes de Medicina. Objetivo: Ao observarmos o adoecimento constante de estudantes, identificamos a necessidade de compreender mecanismos que possam ser considerados disparadores. Assim, investigamos a percepção dos estudantes de Medicina que cursam o estágio supervisionado sobre a síndrome de burnout e a autoidentificação dos sintomas. Método: Realizamos pesquisa qualitativa do tipo estudo de caso utilizando grupo focal como ferramenta metodológica. Participaram desta pesquisa 22 internos divididos em três grupos focais. As falas foram analisadas segundo a análise de conteúdo. Resultados: Dessas análises e de suas inferências, delinearam-se quatro categorias: “(Con)fusão de papéis: o processo de deixar de ser estudante”; “Uma síndrome (in)visível: a banalização do sofrimento”; “Tornar-se médico: forjado no sofrimento”; “(Des)identificação: efeitos de um processo nada fácil”. Conclusão: Os estudantes desconheciam a síndrome e não foram capazes de reconhecer os sintomas dela durante a formação. O achado significativo apontou para a sobrecarga relacionada à falta de tempo e como esta gera um processo de sofrimento nos estudantes. Acredita-se, portanto, que o processo de ensino precisa ser repensado para que os estudantes possam, de fato, aprender e apreender todos os significados que a universidade tem potencialmente a lhes oferecer.
Gender Performativity Seen Through the Eyes of Children: a drag queen mediates literary encounters
Authors: Rosa Cristiano Eduardo da , Felipe Jane
Published: January 2021

ABSTRACT In this article we examine ways in which gender performativity may be recognized by young children, looking at a drag queen’s mediation of literary encounters. The theoretical-analytical framework we employ comes from Gender Studies and Cultural Studies of post-structuralist inspiration. Our text recounts experiences from readings, conversation circles and play activities we organized in a small city in the state of Rio Grande do Sul. Analyzing children’s play and interactions, we observe that from an early age they begin to recognize and question certain expectations about bodies. Contact with art, through literature and other modes of gender performance, can contribute to this reflexive process.
A Creative Process between Painting and Body Arts: Carolee Schneemann and Aby Warburg,
Authors: Pugliese Vera
Published: January 2021

ABSTRACT This article discusses the issue of the pictorial gesture potency in Carolee Schneemann’s creating process and how her use of herself body allowed her to question whether she could, in addition to an image be also an image maker: a poetic and theoretical juxtaposition at the same time, which causes specific displacements in her performative work. This study aims to correlate operatory concepts around the nymph as a theoretical object, with special attention to its accessories in movement, in the Warburgian sense, from the examination of iconological paths and theoretical approaches inaugurated by Aby Warburg, having as focus the crossings between painting and the body arts.
Refusal and Adhesion: resistance between studies of cognition and theater education
Authors: Magela André Luiz Lopes
Published: January 2021

ABSTRACT This article presents reflections on certain public education policy guidelines, oriented to the labor market and exemplified by Organisation for Economic Co-operation and Development (OECD) recommendations, concerning their influence on artistic education and, more precisely, theater education. It addresses existing problems in the field of education in Brazil and France, with emphasis on conceptual causes. In a possible contribution to debates on utilitarianism in theater education, the concept of resistance, present in Michel Foucault’s works, is used as mediator in the utilization of cognition studies to analyze the planning, practice and evaluation of theater classes in primary schools.
Transnationality and Modes of Production in Theatre Studies
Authors: Andrade Clara de , Guenzburger Gustavo
Published: January 2021

ABSTRACT Transnationality and Modes of Production in Theatre Studies - This paper presents an argument in favor of a transnational approach which also examines modes of production within theatre studies in Brazil. Drawing on discussions that took place in July, 2018, at the Philanthropy, Development and the Arts international conference in Munich, we point to new possibilities that may enrich various fields of theatre research. In several cases discussed at the conference and summarized in this article, seemingly local issues and practices revealed their recurrence in other parts of the world (Brazil included), thus demonstrating their interconnection within transnational networks and circuits. In conclusion, it is suggested that the study of theatre from the perspective of transnationality and modes of production may also constitute an action in defense of research, and of the cultural milieu itself, particularly in countries that are living through reactionary periods, as is the case for Brazil today.
La educación escolar en el norte de Yakutia (Rusia) en el contexto de un enfoque indígena
Authors: Neustroev Nikolai Dmitrievich , Neustroeva Anna Nikolaevna , Shergina Tuyaara Alekseevna , Kozhurova Alina Alekseevna , Osipova Sardaana Ignatievna
Published: January 2021

La relevancia de esta investigación está determinada por la modernización y regionalización del sistema educativo en el contexto de los requisitos de los nuevos Estándares Educativos del Estado Federal (FSES), y teniendo en cuenta las particularidades de la educación escolar en el norte de la República de Sakha (Yakutia) basado en un enfoque indígena. El propósito del estudio es la organización variable de la educación escolar en el Norte, teniendo en cuenta la forma de vida y actividad tradicional específica de los pueblos indígenas del Norte. Los enfoques rectores de la investigación son socioculturales, etnopedagógicos y activos en términos del carácter local aplicado del estudio. Los autores del presente estudio revelan las características y problemas de la organización de la educación escolar, y las formas de su implementación variable de acuerdo a los requerimientos del FSES en las condiciones específicas del Norte. Métodos de búsqueda. El método rector del estudio es un experimento pedagógico, un análisis de la educación escolar en el norte en el contexto de un enfoque indígena y la implementación del programa “Somos niños de la tierra de Olonkho”. Los autores evidencian la necesidad de ampliar las funciones sociales de las escuelas rurales del Norte en términos de desarrollo de centros sociopedagógicos en los lugares de residencia compacta de los pueblos indígenas.
Riesgos psicológicos en adolescentes en situación de pobreza de un pueblo de la selva peruana
Authors: Vega Montoya Yndolina , Cjuno Julio
Published: January 2021

El objetivo del presente trabajo es determinar las relaciones de las variables de riesgos psicológicos: satisfacción vital, autoestima, motivación de logro y expectativas de futuro de los adolescentes de un pueblo de la selva peruana que viven en pobreza. La metodología se basa en un estudio transversal, donde se dedujeron frecuencias relativas y absolutas, del mismo modo medidas de tendencia central y de dispersión, así también se analizó las relaciones de las variables a través del Chi cuadrado de Pearson con una confiabilidad del 95%. Los adolescentes involucrados en el estudio tuvieron una edad media de 14 años, la mayoría 69 (53.5%) fueron de sexo masculino y 37 (28.7%) sin  escolaridad. Así también, 102 (79.1%) reportaron una satisfacción vital baja, 68 (52.7%) autoestima baja, 90 (69.8%) motivación de logro bajo y 86 (66.7) expectativas del futuro bajo. Se encontró relación significativa entre las variables sexo (p=,011) y satisfacción vital (p=,054) con expectativas del futuro. Así también, expectativas del futuro se relacionó con la satisfacción vital (p=,054) y la autoestima se relacionó con la motivación de logro (p=,004). Todas las variables de riesgos psicológicos reportan alta prevalencia del nivel bajo, el sexo y no tener escolaridad influyen 1de forma significativa, reforzado con la condición de pobreza en el que viven. Se requiere promover la atención de la salud psicológica de esta población a través de implementación del servicio de salud mental comunitaria en la selva peruana.
Ecosistema con creatividad, investigación e innovación basado en las competencias transversales frente a las exigencias profesionales del siglo XXI
Authors: Romero Carrión Violeta L. , García Flores Segundo A. , Palacios Sánchez José M.
Published: January 2021

El objetivo de la investigación fue determinar si el Ecosistema con creatividad, investigación e innovación, basado en las competencias transversales, responde a las exigencias profesionales del siglo XXI. Para el estudio se aplicó el cuestionario de competencias transversales, del Proyecto Tuning, dirigido a 30 estudiantes universitarios, en cuyo caso se indagó sobre el logro en su formación, mientras que, en el caso de los 30 empleadores, fue conocer la importancia que le asignan a las competencias que deben poseer los nuevos profesionales. Luego de probar la normalidad de la distribución de los datos, se aplicó el estadístico de prueba de hipótesis T de Student para muestras independientes, obteniendo un valor altamente significativo, con respecto a que las competencias comprendidas en el Ecosistema con creatividad, investigación e innovación, son distintas, entre lo logrado por los estudiantes y lo exigido a los nuevos profesionales por los empleadores de las organizaciones del siglo XXI.  Se recomienda disminuir la brecha entre las competencias transversales, logradas por los universitarios y las exigidas por los empleadores, mediante la actualización frecuente del currículo de estudio acorde a las demandas del mercado laboral.
Voluntariado en educación superior como base para el desarrollo profesional de los docentes
Authors: Vasileva Aitalina Nikolaevna , Koryakina Tatyana Grigoryevna , Nogovitscyna Nadezhda Mikhailovna , Nikiforova Tatyana Ivanovna , Adamova Liubov Konstantinovna
Published: January 2021

El propósito de este trabajo es definir el papel de las actividades de voluntariado en el desarrollo profesional de los futuros docentes que actualmente son estudiantes de instituciones de educación superior. El principal método de investigación utilizado en este trabajo es descriptivo y cualitativo, ya que analiza un número de estudiantes voluntarios en el Instituto Pedagógico de la Universidad Federal del Nordeste de Ammosov (Sakha, Rusia) sobre la base de los resultados de la investigación sociológica anual de NEFU “Estudiante” para el período 2017-2019 y examinar su motivación por ser voluntario(a) a través de una encuesta. Los estudiantes se ofrecieron como voluntarios en una amplia gama de actividades: programas educativos, formación práctica académica, preparación de artículos científicos e implementación de proyectos socialmente significativos. Cuando los estudiantes universitarios de  pedagogía organizaron sus actividades de voluntariado para relacionarlas con sus futuras actividades profesionales, ampliaron significativamente sus conocimientos sobre la profesión elegida, reforzaron su motivación para el desarrollo profesional y generaron adecuadas autoevaluaciones de sus cualidades personales y profesionales como futuros docentes. En conclusión: la actividad de voluntariado con orientación profesional como parte de la formación de futuros profesores desarrolla no solo las cualidades y competencias profesionales requeridas, sino que también se convierte en una etapa de su profesionalización, ayudándoles a encontrar su lugar de trabajo más rápidamente y desarrollando sus habilidades sociales y profesionales. Las implicaciones prácticas del estudio radican en la posibilidad de utilizar los resultados de la investigación para organizar actividades de voluntariado en las universidades.