bluuebunny/crossref_metadata_2025 huggingface dataset:
Clustering of business structures by the level of their digital maturity using two approaches: iterative and hierarchical
Authors: Strutynska Iryna
Published: January 2020

Purpose. The aim of the article is experimental finding of the optimal number of clusters and their characteristic features for interpreted (understandable) segmentation of business structures by the level of digital maturity by several methods; comparing the results obtained by different methods and determining the most effective for a particular data analysis task. Methodology of research. Two clustering methods are used in the study: 1) using the Data Mining add-in for MS Excel spread sheets. Clustering capabilities in MS Excel are represented by iterative algorithms: k-means and Expectation-Maximization. For the reference, it was determined EM-algorithm; 2) using the functions of libraries for machine learning Python programming language. Findings. An experimental comparison of the use of two approaches to the clustering of respondents according to the results of online questionnaire using Google Forms service – hard and soft clustering, is conducted. Hard clustering was implemented using Python tools using the hierarchical agglomerative method, soft using the Data Mining add-in MS Excel and using the iterative EM method. A comparative analysis of the results obtained by the two methods showed that the agglomerative hierarchical clustering method is an effective method for solving the problem of clustering of mixed-type data obtained from the survey of respondents. Originality. An algorithm for solving the problem of respondents' clustering according to the results of online survey is proposed, including the stages of collection, preparation of data, obtaining the main results and development of future goals, which will help to solve the problem of processing and clustering of data of mixed type and to provide higher productivity of analytical data and analytical data. Practical value. This approach can be used to develop a Digital Transformation Index for domestic business structures and to measure their digital maturity, which will enhance their economic potential and therefore the country's economy. Key words: digital maturity; digital transformation; business structures; clustering methods; mixed-type data; surveys.
New elements of technology for the growing and protection of tobacco from harmful organisms and its economic substantiation
Authors: Bialkovska Hanna , Pashchenko Volodymyr
Published: January 2020

Purpose. The aim of the article is to study the influence of ecologically safe pesticides on a height and development of plants of tobacco and realization of economic evaluation of his results.

Methodology of research. Scientific methods are used in the process of the study: bibliographic (study and working of scientific works that touch technology of growing of tobacco); agronomical - for the study of norms of bringing of experimental preparations; economic method – at treatment of results of scientific researches for 2016-2018 years; method of comparative analysis – for the estimation of economic efficiency of different technologies of growing of tobacco.

Findings. The new elements of technology of growing and defence of tobacco are reasonable from illnesses and wreckers and she is conducted complete economic evaluation. Recommendations are worked out with the use of growth factor Pennant and to insecticide Commander as effective preparations of increase of the productivity and quality of tobacco raw material of new variety of tobacco of the Ukrainian selection Berley 46 in the agro-climatic conditions of Prydnistrovia of Ukraine. Their application considerably promotes the level of profitability of process of growing of tobacco raw material due to the increase of firmness of plants to the unfavourable factors of environment and assists the increase of competitiveness of tobacco industry of our state in the world market.

Originality. In the process of research next results that have a scientific novelty are got: the new elements of technology of growing and defence of tobacco are worked out from illnesses and wreckers with the use of new environmentally sound preparations – growth factor Pennant and to insecticide knight Commander on the tobacco areas of sort Berley 46 in the Prydnistrovia’s region of Ukraine. The indexes of economic efficiency of new elements of technology are reasonable.

Practical value. An application domain is agricultural enterprises of Prydnistrovia of Ukraine of all legal forms that engage in growing of tobacco.

Key words: tobacco; varieties; technology; immunity; diseases; pests; growth promoters; insecticides; cost; price; profit; profitability level; economic efficiency.
Basic principles of modernization of social and labour relations in the context of regulation of incomes of rural population
Authors: Stasiv Oleh , Kotko Nataliia , Mahas Liubov
Published: January 2020

Purpose. The aim of the article is to carry out a study of the current state of social and labour relations on the basis of scientifically-grounded analysis of the most general indicators such as employment and unemployment, remuneration and living standards of rural population, and further modernization of social and labour relations in the context of regulating rural population incomes.

Methodology of research. General scientific methods are used in the research, in particular: statistical, economic analysis – to determine the status and dynamics of such indicators as employment and unemployment, remuneration and living standards of the rural population; tabular – to organize the statistics.

Findings. The problems of formation of the level of economic activity, employment and unemployment of the rural population of Ukraine and the Carpathian region are generalized, and the factors that significantly influence the formation of social and labour relations of the rural population are characterized. The following statements are established in the article, in particular: intensive processes of workforce dismissal by agricultural enterprises, narrowing the scope of work in rural areas cause a high level of informal employment of rural population, intensifying its migration behaviour, which, ultimately, leads to changes in the sphere of income generation. The analysis of modern and perspective directions of modernization of social and labour relations is carried out.

Originality. A systematic approach is used to outline the problems and features of modernization of social and labour relations in the context of rural population income.

Practical value. The obtained results will provide a scientific substantiation for the social and economic performance of the state measures taken to increase social standards, income and living standards of the rural population, and further develop social and labour relations.

Key words: economically active population; employment; rural population; social and labour relations.
The development of organizational and economic mechanism of food security in ancient times
Authors: Pruntseva Gelena
Published: January 2020

Pruntseva G.О. THE DEVELOPMENT OF ORGANIZATIONAL AND ECONOMIC MECHANISM OF FOOD SECURITY IN ANCIENT TIMES
Purpose. The aim of the study is to determine the basic principles of food security in ancient times and highlight the first tools of food security mechanism, which allowed for the further development of society.
Methodology of research. The following methods are used in the research process, namely: analytical and historical methods to analyze the historical development of the main tools for ensuring food security. Assessment and logic are used to formulate the conclusions of the historical analysis.
Findings. It is found that the problem of food security was relevant in primitive times. In ancient times, the following tools can be distinguished: warehousing and distribution of food products among all members of the community. The main characteristics of the organizational and economic mechanism of food security in ancient times are determined. The historical development of the food supply system of the population is analyzed.
Originality. The main components of the food security system in ancient times are highlighted. For the first time the main tools of the food system are identified. It is proved that with the advent of the first states and the development of irrigation facilities, agricultural production became more efficient, namely: the use of agricultural technologies made it easier for people to work and increased agricultural production productivity. The development of transport infrastructure ensured the efficient exchange and trade of food products.
Practical value. The author’s generalizations regarding the use of food security tools by primitive and ancient civilizations are important in the modern system of economic relations since, in the absence of effective medical treatment and government support for the vulnerable groups of the population, they ensured the survival of primitive people and the development of ancient civilizations. The results of the study are the basis for improving the modern mechanism of food security and will help to formulate an effective state policy in the field of food security.
Key words: food security; agricultural production; prices; products; exchange; social programs.
Price in the system of market characteristics of fruit and berry products
Authors: Kolokolchykova Iryna
Published: January 2020

Kolokolchykova I.V. PRICE IN THE SYSTEM OF MARKET CHARACTERISTICS OF FRUIT AND BERRY PRODUCTS
Purpose. The aim of the article is the analysis of the economic category “price” in the system of market characteristics of fruit and berry products in its theoretical and practical aspect.
Methodology of research. The method of complex approach is used in the process of research of theoretical aspects of economic category “price”. Using the method of systematic analysis made it possible to identify the main groups of factors that influence the pricing of fruit and berry products. The monographic method has made it possible to detect changes in the price level for the products of the industry over the last 6 years in the context of each month. The method of comparisons is used in the process of analysing the impact of price and shaping factors, assessing the level of influence of constituents on the market products of the industry and finding ways to solve them in an effective way.
Findings. It is established that, in theory, the price of production has a close relationship with labour theory and marginal utility theory; in practical terms, this category reflects the market levers of influence both on the market and on business entities. The factors influencing the price of fruit and berry products at micro and macro levels are systematized and grouped into blocks. The cyclicality of changes in the price level for fruits and berries during the year is revealed. The range of problems is outlined and a vector of action is identified with the aim of raising the price level and increasing the efficiency of the horticulture industry as a whole.
Originality. The grouping of factors influencing price formation in the system of market characteristics of fruit and berry products is proposed. This approach makes it possible to assess the impact of each factor individually and to calculate the degree of risk in the directions, while at the same time looking for directions to reduce that impact.
Practical value. The proposed research findings are useful and have practical value for fruit and berry producers. The ability to analyse the factors influencing the pricing and their expert evaluation will allow entrepreneurs to determine the direction of consolidation of actions in the market, will give impetus to the processes of cooperation in matters of storage, sale or processing of products. Analysis of the sale price during the year is a valid substantiation for the introduction of changes in the commodity policy of enterprises, namely the increase in the share of products of early and late varieties, which are always sold at the highest prices.
Key words: demand; supply; price; pricing; fruit and berry market; market players; consumers.
Retrograde Extrapolation of Blood Alcohol Concentration A theoretical and practical approach
Authors: Dumbrava Dan Perju , Radu Carmen Corina , Chiroban Ovidiu , Bulgaru-Iliescu Diana , Iov Tatiana , Damian Simona Irina , Ureche Daniel
Published: January 2020

The influence of high blood alcohol levels in vehicle drivers involved in car accidents is a growing process, despite the legal punishments which have been already increasing in severity. Therefore, determining the level of blood alcohol concentration at the moment of the car accident is essential in establishing the legal responsibility of the driver. However this exact determination is in most of the cases difficult, due to the fact that between the moment of the car accident and the collecting of the blood in a medical unity a varying time frame passes, depending essentially of the distance from the place of the car accident and the hospital. Even more, from a juridical point of view, at the moment the blood is taken from the driver in the hospital, this is not representing a social danger anymore because he is not driving. Hence, the retrograde extrapolation of blood alcohol concentration is and should be the legal tool of providing the juridical system a valid answer at the question implying the value of the blood alcohol concentration at the moment the antisocial deed (car accident) had been made. The aim of this article is to theoretically present the scientific method of retrograde extrapolation of blood alcohol concentration and also to highlight its strong and weak points.
Optimization of the Activated Carbon Preparation from Avocado Seeds, using the Response Surface Methodology
Authors: Fregue Tagne Tiegam Rufis , Ionel Ioana , Gabche Anagho Solomon , Mihaiuti Alin-Cristian
Published: January 2020

Avocado seeds based activated carbon was prepared using chemical activation method which consisted of potassium hydroxide treatment. The main factors influencing the preparation of activated carbons at the calcination temperature, the concentration of the activating agent and the duration of calcination were investigated. One used as a mathematical model the response surface methodology to correlate the response. The significant factors identified by the analysis of variance (ANOVA) through the t-test, the Pareto diagram and the diagrams of surfaces. The optimum avocado seeds based activated carbon was obtained by using calcination temperature of 450 oC, concentration of activating agent of 0.3 mol/L and time of calcination of 3.0 h, which resulted to an avocado seed based activated carbon iodine number remove of 1142.1 mg/g and yield of 75.09 %, by mass. The best activated carbon obtained under the previous conditions and the raw biomass was characterized by Fourier transform infrared and Scanning Electronic Microscope.
Liposomes, Formulation and Pharmacotechnical Assessment of Anti-Acne Preparations
Authors: Tatu Alin Laurentiu , Elisei Alina Mihaela , Bezman Violeta , Diaconu Camelia , Buzia Olimpia Dumitriu
Published: January 2020

The present study aims at obtaining an efficient local formulation able to ensure both stability and increased penetration of the active ingredients in effective optimal concentrations without side-effects. The novelty of this study is the association in an encapsulated form (liposomes) of tretinoin to benzoyl peroxide as an innovative alternative capable of minimizing side-effects, but preserving at the same time their efficiency. The pharmaceutical forms using liposomes ensure the controlled release of medicine, as a result of the encapsulation of the active substances in the amphiphile structure�liposomes, with the possibility to diminish irritating secondary reactions in various forms of acne, and to provide efficiency, tollerability, conformity and cosmetic acceptability, to be proved in a future study.
Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration
Authors: Iorga Raluca Eugenia , Danulescu Razvana Sorina Munteanu , Ozturk Manuela , Costin Danut
Published: January 2020

Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. Were monitored the evolution of oxidative stress markers before and after treatment. This is a case-control study, which included 59 patients diagnosed with AMD and 64 healthy controls. According to the AREDS classification, the patients were divided into two classes, moderate and severe form AMD and were treated with antioxidants, neurotrophic drugs, intravitreal injections with antiangiogenic factors. We followed the patients over a 12-month period and we evaluated the oxidative stress markers such as superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), glutathione peroxidase (GPx), before and after treatment. By comparing the mean values of SOD, TBARS in the two groups, we found that they were significantly higher in the study group compared to the control group, being higher in patients with severe disease. These values decreased after treatment, but they have remained higher than in controls. This research supports the role of oxidative stress in AMD. This paper opens the perspectives of possible elucidations of the AMD pathogenesis dilemma and supports the need to monitor the evolution by assessing the oxidative stress markers.
HPLC-UV Determination of Dextromethorphan in Syrup Method validation
Authors: Avram Nicolae , Heghes Simona Codruta , Rus Luca-Liviu , Juncan Anca Maria , Rus Lucia Maria , Filip Lorena , Filip Corina Roman
Published: January 2020

A HPLC-UV method, for determination of dextromethorphan hydrobromide in syrup, was validated. The chromatographic analysis was performed using an RP-18, Nucleodur chromatographic column (250 mm � 4 mm, 5 �m) at constant temperature (50oC) with a mobile phase consisting of a mixture of acetonitrile/methanol (70:30 v/v) with sodium docusate (as ion pair agent) and ammonium nitrate, pH = 3.4. The flow rate of the mobile phase was 1 mL/min and the detection was carried out at 280 nm. System suitability, specificity, linearity, precision, accuracy, limit of detection and limit of quantification agreed with current pharmacopeial requests. The method is suitable for routine analysis of dextromethorphan hydrobromide in syrup.
Biochemical Study of Cerebrospinal Liquid Composition on a Lot of Newborns with Hydrocephaly
Authors: Manea Aniko Maria , Cioboata Daniela , Stroescu Ramona , Boia Marioara , Motoc Marilena
Published: January 2020

Hydrocephaly represents the accumulation of cerebrospinal liquid at cerebral level and it associates with the increasing of intracranial pressure with multiple effects at the level of cerebral tissue. The cerebrospinal fluid (CSF) is a fluid with a clear appearance, with a composition that changes depending on gestational age and associated pathology. Newborns, especially premature, are more susceptible to develop hydrocephaly and a significant percentage out of these will develop neurological deficits and complications associated with ventriculo-peritoneal shunt. The study was carried out in the Department of Neonatology and Premature from the Clinical Emergency Hospital for Children Louis urcanu Timisoara, in a period of 3 years (2014-2016). There were 26 patients included in the study, who presented hydrocephaly diagnosis supported clinically, by ultrasound and CT. There were conducted dosages in dynamics of CSF composition, depending on pathology: malformative, infectious or hemorrhagic.
Galvanic Corrosion of Ductile Cast Iron Coupled with Different Alloys in Synthetic Domestic Waste Water
Authors: Savin Cristian , Nejneru Carmen , Perju Manuela Cristina , Bejinariu Costica , Burduhos-Nergis Diana , Sandu Andrei Victor
Published: January 2020

Waste water is an aggressive environment for transport pumps to treatment plants. The pumps used are generally, immersion pumps and are made of various elements like, rotor, stator, housing, screws, flanges, springs, seals, etc. The construction elements of the pumps are made of various metallic materials, such as nodular cast iron, gray cast iron, low alloy steel, stainless steel, aluminum, bronze, brass, copper, etc. When immersed in waste water, the metals form galvanic series. The paper presents the galvanic corrosion analysis of the above-mentioned metals in case the corrosive environment is waste water with various compositions.
Synthesis of 4-(4-Hydroxyaryl)-1,3-Dithiolium Perchlorates
Authors: Bahrin Lucian Gabriel , Lungu Catalin Neculai , Asaftei Iuliean Vasile , Sandu Ion
Published: January 2020

4-(3,5-Dibromo-4-hydroxyphenyl)-2-(N,N-dialkylamino)-1,3-dithiol-2-ylium perchlorates have been synthesized by acid catalyzed cyclocondensation of 1-(3,5-dibromo-4-hydroxyphenyl)-1-oxaethan-2-yl dithiocarbamates. The latter compounds have been obtained from the reaction of the corresponding substituted w-bromoacetophenone with various salts of dithiocarbamic acids.
Research on the Carbon Dioxide Emission Factor as a Result of Fuel Combustion
Authors: Cristescu Tudora , Stoica Monica Emanuela , Suditu Silvian
Published: January 2020

The present paper first discusses a calculation model for the complete combustion of fuels � with the minimum amount of air needed � whose volumetric and mass composition is known. It then describes evaluation models for the heat resulting from fuel combustion, i.e., superior and inferior caloric power value. In this context, the carbon dioxide emission factors for fuel and biofuel combustion, respectively, are evaluated. The results obtained have allowed a comparative analysis regarding carbon dioxide emission.
Axillary Lymph Node Dissection Extension in Breast Cancer Between Under and Overtreatment Analysis of a series of cases and literature review
Authors: Ion Daniel , Bolocan Alexandra , Socea Bogdan , Andronic Octavian , Radu Georgiana , Paduraru Dan Nicolae
Published: January 2020

The surgical management of breast cancer tumors depends not only on knowing the right histological type of tumor, but also on identifying the grade of axillary node invasion and the presence of metastases. Unfortunately, due to a lack of general understanding of how these tumors actually spread and their path towards axillary lymph nodes, there is a tendency of over or undertreating patients in the surgical environment. Even though we now have the Sentinel Ganglion method to help us, we haven�t decided on a universally accepted algorithm in the management of this disease. Many studies are still needed in order to fully clarify the most appropriate surgical management for each type of tumor and the level of axillary node dissection. Multiple factors should be taken into account when managing the case of a patient suffering from breast cancer and faced with the need of an axillary lymph node dissection (ALND). We have tried to identify some of these factors based on the experience of our clinic and available literature. The factors identified are the positive SLN (Sentinel Lymphatic Node) aspect, the differentiation between micro and macrometastases, the use of the S classification of SLN and microanatomic location of SLN metastases and the microanatomic location (MAL) of the tumor deposit in the sentinel ganglion.
The Benefits and Risks of Antioxidant Treatment in Liver Diseases
Authors: Gheorghe Gina , Stoian Anca Pantea , Gaman Mihnea-Alexandru , Socea Bogdan , Neagu Tiberiu Paul , Stanescu Ana Maria Alexandra , Bratu Ovidiu Gabriel , Mischianu Dan Liviu Dorel , Suceveanu Andra Iulia , Diaconu Camelia Cristina
Published: January 2020

Chronic liver diseases are a public health issue, because of their high incidence and prevalence, the important impact on the quality of life and high mortality rates. From a pathogenic point of view, in almost all liver diseases there is an increase in oxidative stress. Oxidative stress represents as an imbalance between the production of oxidizing agents and antioxidants. This imbalance contributes to the initiation and progression of hepatic injury. Among the most important risk factors for increased oxidative stress in chronic liver diseases are alcohol, drugs, environmental pollutants and irradiation. For the restoration of the oxidant-antioxidant balance and reduction of the oxidative stress in chronic liver diseases, a promising role may have the antioxidants. This hypothesis is now based on experimental evidence of their efficacy in animal models. In low concentrations, antioxidants improve liver function by preventing the oxidation of an oxidizable substrate, but in high doses, they may cause adverse reactions, such as the pro-oxidant effect, glutathione S transferase inhibition and thus the inhibition of detoxification and interference with coagulation. The objective of the article is to review the benefits of antioxidant treatment in chronic diseases of the liver, in order to put them in balance with their adverse reactions.
In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue
Authors: Balean Octavia Iulia , Galuscan Atena , Jumanca Daniela , Farcas Claudia , Coricovac Dorina , Chioran Doina , Lazureanu Voichita , Podariu Angela Codruta
Published: January 2020

The purpose of this in vitro study was to evaluate the efficacy of three different types of bisphosphonates: Actonel (risedronate sodium), Fosamax (alendronic acid) and Ossica (ibandronic acid) on a squamous carcinoma cell line (SCC-4) with tongue tissue origin. The cell viability was assessed after a stimulation period of 24h and the Alamar Blue test was performed. The assessment revealed that the viability of squamous cell carcinoma was slightly reduced after treatment with the smallest concentration of bisphosphonates, with a lowest rate (89%) recorded for Actonel. When a concentration of 2 and 2.5 mM was used, the cell viability was between 85-89% independently of the type of bisphosphonates used. The higher concentrations of 3 mM, 4 mM showed a significant reduction of 72% when using Fosamax, and 68% when using Ossica. We can state that the viability of tongue squamous cell carcinoma cells decreases as the concentration of bisphosphonates used increases.
Biochemical and Bioimpedance Correlation with Quality of Life and Illness Perception in Hemodialysis Patients
Authors: Donciu Mihaela-Dora , Florea Laura , Mititiuc Luanda-Irina , Popescu Elena-Rodica , Chirita Roxana
Published: January 2020

In hemodialysis patients malnutrition-inflammation syndrome, evaluated by biochemical laboratory analysis and through bioimpedance spectroscopy, was associated to impaired quality of life and with an increased risk of mortality. The present study goal was to investigate, in a cross-sectional analysis, performed in 122 hemodialysis patients, the association between biochemical parameters and bioimpedance-derived measurements the association of undernutrition with quality of life and illness perception. The results showed that our cohort perceived an impaired quality of life and illness perception and that these psychometric evaluation was associated with malnutrition markers.
Particularities of Using Contrast Agents in Diagnosis of Stroke
Authors: Cuciureanu Dan Iulian , Statescu Cristian , Sascau Radu Andy , Cuciureanu Tudor , Constantinescu Victor Alexandru , Hinganu Delia , Preda Cristina , Hinganu Marius Valeriu , Turliuc Mihaela Dana
Published: January 2020

Stroke is the first cause of disability, the second cause of dementia and the third cause of mortality in industrialized countries. Due to its increasing incidence, there is a need to study the possibilities of early prevention and diagnosis. Our study was conducted on a group of 165 selected patients diagnosed with different forms of ischemic strokes, aged between 25 and 50 years. We explored them using contrast injected MRI technique, to show the usefulness of this radiologic method and to propose a protocol for the investigation of clinically diagnosed patients with stroke. Contrast injected MRI is demonstrated to be a gold technique in exploring early cases of ischemic stroke with different anomalies. Special agents combined with this technique allows assessment of the functionality of the blood-brain barrier, revealing the real ischemic penumbra.
Applications of Factorial Analysis in the Study of Risk Factors and their Chemical Influence for Erosive Dental Wea
Authors: Chiriac Adina-Monica , Mercut Veronica , Alexandru Dragos , Popescu Sanda-Mihaela , Mercut Razvan , Popescu Florin-Dan , Luchiancenco Delia , Resceanu Ionut
Published: January 2020

Dental wear is an irreversible loss of dental hard tissues under the action of physical and chemical factors that may come from the external or internal environment of the body. Dental wear is the consequence of three mechanisms: biocorrosion, friction and stress. The purpose of the study was to determine the impact of risk factors on the severity of erosive dental wear in children using factorial analysis. In this context, we used data from a statistical survey conducted between 2017-2018 on 456 rural and urban children aged 6 to 11 years, where dental wear was analyzed according to a series of diet-related factors, oral hygiene and behavioral patterns (bruxism). The major impact was caused by energy drinks, yoghurt and carbonated beverages. Through the associations resulting from the factorial analysis, the mechanisms involved in the erosive dental wear were also highlighted, and the main was biocorrosion, followed by friction and stress.
Effect of Heat Treatment on Magnetic Properties of Bulk Amorphous Alloys Fe63+xCo10Y7-xB20 (x=0, 2)
Authors: Wyslocki Jerzy , Talar Mateusz
Published: January 2020

This paper presents the results of tests on amorphous alloys Fe65Co10Y5B20, Fe63Co10Y7B20 in the state after solidification and after thermal treatment. The thermal treatment was performed below the crystallization temperature and above the Curie temperature (750K/25 min). The samples for the investigation had the shape of rods with a diameter of 1 mm and a length of 20 mm. The structure and magnetic properties were studied for the research material. The structure was investigated using XRD and the magnetic properties using VSM and FERROTESTER. XRD studies showed that the samples both in solidified state and after thermal treatment had an amorphous structure. The losses for the re-magnetization of the tested samples were comparable to those for commercially used FeSi materials. The process of magnetization in the vicinity of the area called the approach to ferromagnetic saturation is associated with all tested samples with rotation of the magnetization vector near free volumes. An interesting result of the conducted research is that not always a thermal treatment made on general principles leads to improvement of magnetic.
An Experimental Study in the Surgical and Anesthesio-Pharmacological Implications of the Practical Applicability of the Concept of Myoplastic Transposition Through a Forearm Fascia Breach
Authors: Pogarasteanu Mark-Edward , Costea Ruxandra , Berami Ahmed , Drignei Elena , Moga Marius , Raita Stefania Mariana , Balaceanu Rosalie Adina , Ionascu Iuliana , Barbilian Raluca , Radu Florentina Ionita
Published: January 2020

The traumatic or surgical amputation of the forearm or of the hand is a challenging interdisciplinary domain, requiring the collaboration of surgeons, engineers, prostheticians, clinical pharmacology experts in chronic pain management, exoprosthesis manufacturing companies, social workers and last but not least the patient himself/herself. There are a relative few methods of surgical preparation of the amputation stump for use use an external prosthesis. Most of these techniques do not provide a sufficient number of electrical sEMG signals for the efficient control of a modern myoelectric exoprosthesis. We present the surgical aspects and anesthesio-pharmacological implications of the practical study into the applicability of the concept of myoplastic transposition through a forearm fascia breach. We present the data and we discuss the results of sEMG signal acquisition, both before and after the procedure, and we conclude regarding the potential of the method as a means of improving the current standard surgical technique.
Our Experience in Skin Grafting and Silver Dressing for Venous Leg Ulcers
Authors: Avino Adelaida , Cozma Cristina-Nicoleta , Balcangiu-Stroescu Andra-Elena , Tanasescu Maria-Daniela , Balan Daniela Gabriela , Timofte Delia , Stoicescu Silvia Maria , Hariga Cristian-Sorin , Ionescu Dorin
Published: January 2020

Silver is used nowadays in numerous domains, from the manufacture of jewelery to the medical field. It has also healing properties being used as a wound dressing that creates an aseptic environment. The management of wound healing using a skin grafts often requires hospital admission, a period of immobility, attentive donor site wound care and pain control. A prospective study was realized to evaluate the silver dressing efficacy in treating lesions after skin grafting of chronic ulcers. Our evaluation showed good results with an accelerated re-epithelialization.
Absorbent Food PADS from Meat Packages-Potential Source of Contamination
Authors: Gaspar Cristina Mirabela , Cocora Zorita Maria , Brudiu Ileana , Lazarescu Cristian Florin , Popovici Ramona Amina , Tigmeanu Codruta Victoria , Tibru Ioan
Published: January 2020

The purpose of this study was to quantify the microbial load and to detect potentially pathogenic germs on the surface of absorbent food pads in the packaging of fresh chicken and minced meat marketed in the retail units in Romania. The load in E. coli, as an indicator of faecal contamination, was significantly lower than that of Enterobacteriacea and coliform germs. Congo red-binding E. coli strains have been identified. The affinity for the Congo red dye is considered a phenotypic marker for the presence of curli fibers. These surface formations give the bacterial strains the ability to form biofilm on various surfaces. Their presence also correlates with the property of these bacterial strains to trigger severe infections in humans. These strains showed 100% resistance to fourth-generation cephalosporins, 87.5% to third-generation cephalosporins and 75% to quinolones. A single strain was resistant to meropenem. All the tested strains were susceptible to gentamicin. Coagulase-positive staphylococci were identified in 40% of the analyzed samples. Of the 30 strains of Staphylococcus spp. tested (coagulase-positive and negative), 63.3% proved to be methicillin-resistant and 43.3% had resistance to sulfamethoxazole-trimethoprim. In one sample, it was detected Salmonella infantis. Thus, it can be appreciated that these absorbent food pads may be a source of direct contamination with potentially pathogenic and / or antibiotic-resistant germs for the persons who manipulates them in their domestic environment, as well as a source of cross-contamination of food and other surfaces in the kitchen.
Pharmacophore Modeling and Docking Study of Pyrazolylaminoquinazoline Derivatives as Highly Potent Fibroblast Growth Factor Receptor Inhibitors2 (FGFR2)
Authors: Crisan Luminita , Varga Daniela , Pacureanu Liliana
Published: January 2020

In this study pharmacophore modeling and molecular docking investigations have been performed on pyrazolylaminoquinazoline derivatives, highly potent fibroblast growth factor receptor2 (FGFR2) inhibitors. The best pharmacophore hypotheses displaying five features (ADHRR.2051 and AADHR.798) were generated using a set of 28 compounds. The associated 3D atom-based quantitative structure � activity relationships (QSAR) models were statistically robust showing high correlation coefficients (R-squared = 0.981 / 0.982), and cross validation coefficients (Q-squared = 0.645 / 0.671). The R-Pearson values for the test set of 0.805 / 0.820 indicate that the models are robust and exhibit good predictive power. The interactions of pyrazolylaminoquinazoline with FGFR2 binding site revealed two hydrogen bonds with Ala567. The obtained pharmacophore, 3D atom-based QSAR models and binding features resulted from docking studies can help medicinal chemists to design new pyrazolylaminoquinazoline inhibitors with improved potency.
Study Regarding the Elastic Impression Biomaterials Dimensional Stability
Authors: Savin Carmen , Antohe Magda-Ecaterina , Balan Adriana , Sirghe Ana , Gavrila Laura
Published: January 2020

In order to have an accurate impression, dimensional modifications must be under control throughout the impression stages, considering they are highly influenced by the variability level during polymerization.The factors with an influence on dimensional stability are:impression material width, tensile modulus, temperature during the imprinting process, storage humidity, the time lapse between imprinting and casting. The study focuses on dimensional modifications of varied elastic impression materials, considering both testing and impression techniques are done in similar conditions in order to assess accurately the behaviour of varied impression materials.Material and methods:The study was based on a laboratory simulation of a clinical situation. There were used two 6-year maxillary molars in the position they have in the oral cavity. A 3 mm wax layer was added during the next stage its width being checked with an Ivoclar mechanical vernier. The surface parallelism was subsequently checked using a parallelograph and there was taken an individual tray made of photopolymer acrylic. The measurements of this study were limited to the linear dimension, being observed the changes occurred in one direction, although contraction is a volumetric modification.The statistic assessment of the measurement data obtained in the case of the same type of addition silicon materials recorded an increase of the volumetric contraction type in dry environment and in longer time intervals.The addition materials were significantly superior in terms of contraction time, as compared to the previous case, granting higher accuracy to the end product. The Silagum Light presented an increased volumetric contraction in moist environment, the contraction being more significant in longer time intervals. The Xantopren L blue material has a reduced deformation gradient in less than 48 h.
Studies About Degradation of Zirconia in Artificial Saliva
Authors: David Sabina , Sarbu Ioan , Cotrut Mihai Cosmin , Comaneanu Raluca Monica , Stoian Mirel , Patroi Dan Nicolae
Published: January 2020

To study zirconia degradation, we used samples with 16.5 mm diameter and 3 mm thick, milled from IPS e.max Zir CAD disks and subjected to sintering. Samples were immersed in Fusayama Meyer artificial saliva, removed after one day, 3 days, 7 days, 14 days and 21 days and examined from the point of view of surface morphology and elemental composition with an electronic scanning microscope. By SEM examining of samples prior to immersion in artificial saliva we found that the material contained strictly the chemical elements specified by the manufacturer. SEM examination and mass evaluations performed after immersion in artificial saliva demonstrate that the material did not suffer degradation processes, the minimum differences in the measurements being within the analytical balance weighing range.
Energy and Chemicals Consumption Evaluation in Water Treatment Plant. A comparative study between Bacau and Turin
Authors: Fabian Florina , Nedeff Valentin , Birsan Narcis , Mosnegutu Emilian
Published: January 2020

The total energy demand of water treatment plant Bacau (WTP Bacau) was evaluated at 239.94 MW h/y, in case of SMAT (Turin-Iataly) total energy demand of the plant was evaluated at 2.235,454.9 MW h/y, and 6,9 % is for WT. Chemicals consumption, is relative and depends on raw water turbidity at WTP Bacau, during the winter period raw water is very clean and requires only a simple chlorination, on the other hand at SMAT chemicals consumption, is 5.325 t/y and 8.8% is used for water treatment process.
A Novel Method of Validation of the QSPRs Based on Molecular Similarity
Authors: Hrubaru Madalina , Tarko Laszlo
Published: January 2020

For practical drug design purposes, the proposed method should be applied only if the analyzed database includes a prediction set (a group of a new molecules, not yet synthesized, with unknown values of the dependent property). The characteristics of the proposed method are: a) elimination of some molecules from the initial calibration and prediction sets, according to the result of a specific molecular similarity procedure b) the validation set is identified based on the results of similarity calculations and includes the molecules of the new calibration set most similar to the molecules of the new prediction set c) inclusion of the validation set in the new calibration set, used for model building d) it uses an original mathematical formula as validation function e) the most suitable equation for the description of the molecules in the new calibration set is different from the validated equation; these two equations are identified within the group of the best 1000 QSPRs f) the validated equation is considered the most suitable equation for the description of the molecules in the new prediction set. In five QSPR studies the validated equation made better prediction for molecules in the new prediction set than the most suitable equation for the description of molecules in the new calibration set. In the sixth study the proposed method produced, for the same prediction set, a better result than an external validation method.
Assessment of Bacteria Resistance According to Antibiotic Chemical Structure
Authors: Duceac Letitia Doina , Banu Elena Ariela , Baciu Ginel , Lupu Vasile Valeriu , Ciomaga Irina Mihaela , Tarca Elena , Mitrea Geta , Ichim Daniela Luminita , Damir Daniela , Constantin Marcu , Luca Alina Costina
Published: January 2020

Modern medicine has a vast set of antibiotics frequently prescribed in therapeutic practice. Beta-lactam antibiotics are often indicated in prophylaxis and treatment of bacterial infections caused by susceptible microorganisms. This work concerned on analysis of antibiotic structure influence on antibiotic resistance knowing that a wide variety of bacteria developed different mechanism that make bacteria resistant to some or to nearly all antibiotics. The emergence of antibiotic-resistant pathogens is a relevant area of study in medical practice. Furthermore, multi-drug resistance is a worldwide healthcare issue tightly connected to hospital acquired infections.
New Electrochemical Detection Strategies for Iodinated Compounds
Authors: Chelmea Ligia , Modugno Federico Di , Samota Iosif , Bobescu Elena , Floroian Laura , Restani Patrizia , Cioca Gabriela , Bungau Simona , Badea Mihaela
Published: January 2020

Iodine is a micronutrient of high importance for the health and good development of individuals. It is contained in many foods, but it is also part of the chemical component of oceans and soil. Its deficiency is still a problem of humanity, which has a serious repercussion on our health. It is therefore important to have specific, fast and cost effective methods of iodine detection from different samples. This work aims to identify optimal parameters for potassium iodide (KI) detection from different media, to be further applied to real samples: plant extracts, water, biological fluids. Results showed a significant difference in electrochemical results, depending on the pH values of the mixture and also on the time which influences the compounds stability. Differential pulse voltammetry and cyclic voltammetry using carbon printed sensors, as well as microsensors for redox status or direct iodide detection are important analytical tools which have a wide range of applications in the food, medicine, toxicology and other domains.
Electro-Optical and Spectral Comparative Study of Some Triazolium Methylids with Biomedical Applications
Authors: Melniciuc Puica Nicoleta , Ivan Liliana Mihaela , Closca Valentina , Dorohoi Dana Ortansa
Published: January 2020

Some electro-optical characteristics of four carbanion monosubstituted triazolium ylids - precursors in obtaining new heterocycle derivatives with pharmaceutical and industrial applications - were evaluated by spectral and quantum-mechanics studies. The physical properties were established for the optimized structures of triazolium ylids using HyperChem 8. The nature of the interactions solute-solvent in the triazolium ylid solutions was established by correlations between the polarity/polarizability characteristics of the solution components and the wavenumbers of the visible band.
Procalcitonin as a Marker of the Systemic Inflammatory Response to Infection on Newborn and Children (up to 1 year)
Authors: Ilyes Gabriel , Mladin Narcisa Carmen , Craina Marius , Petre Izabella , Suciu Nicolae , Tudor Anca , Oancea Roxana , Andor Bogdan , Radu Daniela
Published: January 2020

In the last years, procalcitonin (PCT) has been proposed as an early marker of infections in newborns having registered different results. In this study, we aimed to investigate the value of serum procalcitonin for the diagnosis of sepsis in neonates and children procalcitonin in the diagnosis of neonatal sepsis and in children up to 1 year in the pathology of therespiratory system, gastrointestinal pathology, etc. At first, we established the clinical and paraclinical signs of systemic inflammation: increasing the temperature of the system, tachycardia, laboratory test: leukocytosis, C-reactive protein - for the diagnosis of sepsis.Some studies show that PCT gave a sensitivity between 83-100% and a specificity between 70-100% in early diagnosis of neonatal sepsis [1-7]; other researches question the accuracy of PCT in detecting neonatal sepsis.Procalcitonin (PCT) has been proposed as a marker of bacterial sepsis in critically ill patients. PCT is a precursor of calcitonin and a 116 amino acids protein. PCT levels more than 0.5 mg/dl are useful to determine the type of infectious process (bacterial or not).
Correlation of the Theoretical Study with the Experimental Determination of the Antibacterial Effect of Vaccinium myrtillus folium (VM-f) Plant Extract
Authors: Rotaru Luciana Teodora
Published: January 2020

The last century was marked by efforts to search for natural compounds with antibacterial therapeutic properties, due to the gradual reduction of the number of effective allopathic antibiotics and on the toxic effects of antibiotic residues in animal products. Medicinal plants are considered new resources for producing agents that could act as alternatives to antibiotics in the treatment of antibiotic-resistant bacteria. We determined the polyphenolic composition of the tested plant extract by HPLC technique. The aim of this study was to evaluate the antibacterial activity of Vaccinum myrtillus folium (VM-f) ethanolic extract, using the diffusion method on nutritive agar (Kirby-Bauer). We compared the experimental results with the theoretical antibacterial activity calculated with AUTODOCK 4.2.