bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental Considerations and Sustainable Solutions for Outdoor Advertising Banners
Authors: Cuc Sunhilde , Secan Cristina
Published: June 2024

Despite advancements in digital technology, outdoor advertising remains a robust communication tool with broad audience appeal. However, heightened environmental awareness necessitates proactive measures within the industry. This study examines the environmental impact of banners and proposes sustainable strategies. Market analysis underscores the widespread use of banners despite alternative advertising methods, prompting an investigation into their environmental implications and mitigation solutions. The research specifically focuses on prolonging banner lifespan and campaign duration through innovative recycling approaches aligned with circular economy principles. A comprehensive literature review informs these models and strategies, identifying opportunities for sustainable banner management. A case study approach is employed to present the transformation of banners into functional raincoats using Gemini X20 Pattern Designer software. The study emphasizes the optimization of resources and adherence to copyright regulations. This practical example demonstrates the feasibility and benefits of recycling in outdoor advertising. Collaborations with tailoring workshops facilitate community engagement and contribute to economic benefits. The implementation of these practices by companies serves to enhance their sustainability credentials and leadership in environmental responsibility within the outdoor advertising sector. In conclusion, this study provides valuable insights into sustainable practices that mitigate environmental impacts while fostering economic and social benefits.
Human–Robot Collaboration on a Disassembly-Line Balancing Problem with an Advanced Multiobjective Discrete Bees Algorithm
Authors: Shen Yanda , Lu Weidong , Sheng Haowen , Liu Yangkun , Tian Guangdong , Zhang Honghao , Li Zhiwu
Published: June 2024

As resources become increasingly scarce and environmental demands grow, the recycling of products at the end of their lifecycle becomes crucial. Disassembly, as a key stage in the recycling process, plays a decisive role in the sustainability of the entire operation. Advances in automation technology and the integration of Industry 5.0 principles make the balance of human–robot collaborative disassembly lines an important research topic. This study uses disassembly-precedence graphs to clarify disassembly-task information and converts it into a task-precedence matrix. This matrix includes both symmetry and asymmetry, reflecting the dependencies and independencies among disassembly tasks. Based on this, we develop a multiobjective optimisation model that integrates disassembly-task allocation, operation mode selection, and the use of collaborative robots. The objectives are to minimise the number of workstations, the idle rate of the disassembly line, and the energy consumption. Given the asymmetry in disassembly-task attributes, such as the time differences required for disassembling various components and the diverse operation modes, this study employs an evolutionary algorithm to address potential asymmetric optimisation problems. Specifically, we introduce an advanced multi-objective discrete bee algorithm and validate its effectiveness and superiority for solving the disassembly-line balancing problem through a comparative analysis with other algorithms. This research not only provides innovative optimisation strategies for the product-recycling field but also offers valuable experience and reference for the further development of industrial automation and human–robot collaboration.
The Updated Sections of Systems
Authors: Scherer William T.
Published: June 2024

Our journal Systems (https://www [...]
The Role of Institutional Logics in Shaping Sustainable Talent Management: A Comparative Study of Two South Korean Conglomerates
Authors: Lee Joonghak
Published: June 2024

This research examines the evolution of human resource management (HRM) practices within Samsung and Lotte, two major South Korean conglomerates. Both companies have been profoundly influenced by the Japanese management paradigm, especially in areas like seniority-based promotion rooted in Confucian values. Drawing from institutional theory, the study elucidates how similar economic trajectories in South Korea and Japan fostered comparable institutional logics and pressures in HRM. However, as organizations navigate institutional shifts, their responses and resulting HRM adaptations can diverge. Utilizing a comparative approach through the lens of the institutional logic theory, key findings unveil as follows: (1) Samsung and Lotte’s HR practices exhibit a strong Japanese influence, highlighting cultural/historical context’s importance. (2) Despite similar pressures, the conglomerates developed distinct HR practices attributed to differing institutional logics. (3) Institutional logics play a pivotal role in shaping HRM and influencing organizational behavior. (4) Organizations adapt HR practices in response to institutional complexities, leading to practice divergence. (5) The study extends institutional theory’s application in understanding organizations’ varied responses to similar pressures. (6) Findings offer HR professionals insights on tailoring strategies based on contextual understanding. The study extends the application of institutional theory in deciphering varied organizational responses. Practically, it provides HR professionals guidance on contextually appropriate HRM strategies. Companies across Asia can leverage these insights to anticipate HR practice shifts and align them with evolving institutional frameworks.
Adsorption Behavior and Mechanisms of Trihalomethanes onto Virgin and Weathered Polyvinyl Chloride Microplastics
Authors: Li Yi , Neema Paragi , Andrews Susan
Published: June 2024

Microplastics that adsorb various toxic contaminants in water may be transported into cells and organs, possibly posing toxicological risks in the aquatic environment. Disinfection byproducts (DBPs), which are ubiquitous in chlorinated drinking water and wastewater, may have some potential to sorb onto microplastics (MPs) through hydrophobic or electrostatic interactions. However, DBP adsorption on microplastics has not yet been closely examined. This work investigated the adsorption behavior of trihalomethanes (THMs)—a regulated and ubiquitous DBP class in chlorinated water—onto virgin and weathered polyvinyl chloride (PVC) microplastics, the most widely used plastic material in drinking water distribution and sewer systems. A comparative analysis of kinetic and isotherm test results indicated that the adsorption mechanisms mainly involved hydrophobic interactions from a combination of weak and strong physisorption behavior and possibly chemisorption. The adsorption coefficients from all the models examined suggested that the adsorption of THMs, and perhaps chemically similar DBPs, onto virgin PVC microplastics can be 10–20 µg g−1. However, the weathered PVC microplastics contained more polar functional groups, which led to a decreased hydrophobicity and reduced THM adsorption capacity by approximately 10%. These findings offer novel insights into the possible adsorption characteristics of disinfection byproducts (DBPs) onto microplastics and will assist in targeting more toxic DBPs for future investigations.
Tris (2-chloroisopropyl) phosphate and Tris (nonylphenyl) phosphite Promote Human Renal Cell Apoptosis through the ERK/CEPBA/Long Non-Coding RNA Cytoskeleton Regulator Axis
Authors: Zhao Hu , Yan Yi , Gao Yanyan , Wang Jiafu , Li Sheng
Published: June 2024

Organophosphorus compounds (OPs) are widely used and have the potential to be harmful environmental toxicants to humans. Long non-coding RNA (lncRNA) plays a crucial regulatory role in cytotoxicity. This study aimed to investigate the effects of OPs on the expression of lncRNAs in cells. The effects of the industrial OPs TNPP and TCPP on both CYTOR and cellular viability were examined in the following human renal cell lines: HEK293T and HK-2. Both TCPP and TNPP downregulated CYTOR expression, increased reactive oxygen species levels, and induced apoptosis; the upregulated expression of CYTOR resulted in a reduction in apoptosis. The results of the luciferase reporter assay and the knock-down assay indicate that CEBPA binds to the upstream promoter region of CYTOR and regulates its transcription. Furthermore, TCPP and TNPP were found to downregulate the phosphorylation of ERK in the signaling pathway that is upstream of CEBPA. These results indicate that TCPP and TNPP can decrease the level of CEBPA by reducing ERK phosphorylation; this leads to a decrease in CYTOR expression, which further promotes cellular reactive oxygen species and apoptosis. Therefore, the ERK/CEBPA/CYTOR axis is one of the pathways by which organophosphates produce cytotoxicity, leading to renal cell injury. This study presents evidence for both the abnormal expression of lncRNA that is caused by organophosphates and the regulatory function of lncRNA regarding downstream cellular viability.
Progress in Early Detection of HIV in Tajikistan
Authors: Alaei Kamiar , Kwan Brian , Torabzadeh Hamid R. , Akinwalere Adebimpe O. , Saydamirovich Sattorov S. , Mohsinzoda Gafur , Alaei Arash
Published: June 2024

HIV early detection (CD4 counts ≥350 cells/μL) is correlated with higher life expectancy among people living with HIV (PLHIV). Several factors, including physical, cultural, structural, and financial barriers, may limit early detection of HIV. This is a first-of-its-kind study on population-level differences in early detection of HIV across time within Tajikistan and any country in the Central Asia region. Utilizing the Tajikistan Ministry of Health’s national HIV data (N = 10,700) spanning 2010 to 2023, we developed median regression models with the median CD4 cell count as the outcome and with the following predictors: time (years), region, age, gender, and area (urban/rural status). Individuals younger than 19 years old were detected early for HIV, whereas those older than 39 years were detected late. Females were detected earlier compared to their male counterparts regardless of region of residence. Rural populations were detected earlier in most years compared to their urban counterparts. The COVID-19 pandemic accelerated HIV early detection in 2021 but most regions have returned to near pre-pandemic levels of detection in 2022 and 2023. There were differences identified among different demographic and geographic groups which warrant further attention.
A Broad Influenza Vaccine Based on a Heat-Activated, Tissue-Restricted Replication-Competent Herpesvirus
Authors: Vilaboa Nuria , Bloom David C. , Canty William , Voellmy Richard
Published: June 2024

Vaccination with transiently activated replication-competent controlled herpesviruses (RCCVs) expressing influenza A virus hemagglutinins broadly protects mice against lethal influenza virus challenges. The non-replicating RCCVs can be activated to transiently replicate with high efficiency. Activation involves a brief heat treatment to the epidermal administration site in the presence of a drug. The drug co-control is intended as a block to inadvertent reactivation in the nervous system and, secondarily, viremia under adverse conditions. While the broad protective effects observed raise an expectation that RCCVs may be developed as universal flu vaccines, the need for administering a co-activating drug may dampen enthusiasm for such a development. To replace the drug co-control, we isolated keratin gene promoters that were active in skin cells but inactive in nerve cells and other cells in vitro. In a mouse model of lethal central nervous system (CNS) infection, the administration of a recombinant that had the promoter of the infected cell protein 8 (ICP8) gene of a wild-type herpes simplex virus 1 (HSV-1) strain replaced by a keratin promoter did not result in any clinical signs, even at doses of 500 times wild-type virus LD50. Replication of the recombinant was undetectable in brain homogenates. Second-generation RCCVs expressing a subtype H1 hemagglutinin (HA) were generated in which the infected cell protein 4 (ICP4) genes were controlled by a heat switch and the ICP8 gene by the keratin promoter. In mice, these RCCVs replicated efficiently and in a heat-controlled fashion in the epidermal administration site. Immunization with the activated RCCVs induced robust neutralizing antibody responses against influenza viruses and protected against heterologous and cross-group influenza virus challenges.
Protective Effects from Prior Pneumococcal Vaccination in Patients with Chronic Airway Diseases during Hospitalization for Influenza—A Territory-Wide Study
Authors: Kwok Wang-Chun , Lung David Christopher , Tam Terence Chi-Chun , Yap Desmond Yat-Hin , Ma Ting-Fung , Tsui Chung-Ki , Zhang Ru , Lam David Chi-Leung , Ip Mary Sau-Man , Ho James Chung-Man
Published: June 2024

Influenza is an important respiratory viral pathogen in adults, with secondary bacterial pneumonia being a common complication. While pneumococcal vaccines can prevent pneumococcal pneumonia and invasive pneumococcal disease, whether they can also prevent the severe in-hospital outcomes among patients hospitalized for influenza has not been examined. A territory-wide retrospective study was conducted in Hong Kong, which included all adult patients having chronic airway diseases (asthma, bronchiectasis, and chronic obstructive pulmonary disease) hospitalized for influenza and who had received seasonal influenza vaccine. The occurrence of secondary bacterial pneumonia, mortality, and other severe in-hospital outcomes were compared among subjects with or without pneumococcal vaccination. There was a total of 3066 eligible patients who were hospitalized for influenza in public hospitals in Hong Kong from 1 January 2016 to 30 June 2023. Completed pneumococcal vaccination with PSV23/PCV13 conferred protection against secondary bacterial pneumonia, all-cause mortality, and respiratory cause of mortality with adjusted odds ratios of 0.74 (95% CI = 0.57–0.95, p = 0.019), 0.12 (95% CI = 0.03–0.53, p = 0.005), and 0.04 (95% CI = 0.00–0.527, p = 0.0038), respectively.
Feline Infectious Peritonitis mRNA Vaccine Elicits Both Humoral and Cellular Immune Responses in Mice
Authors: Brostoff Terza , Savage Hannah P. , Jackson Kenneth A. , Dutra Joseph C. , Fontaine Justin H. , Hartigan-O’Connor Dennis J. , Carney Randy P. , Pesavento Patricia A.
Published: June 2024

Feline infectious peritonitis (FIP) is a devastating and often fatal disease caused by feline coronavirus (FCoV). Currently, there is no widely used vaccine for FIP, and many attempts using a variety of platforms have been largely unsuccessful due to the disease’s highly complicated pathogenesis. One such complication is antibody-dependent enhancement (ADE) seen in FIP, which occurs when sub-neutralizing antibody responses to viral surface proteins paradoxically enhance disease. A novel vaccine strategy is presented here that can overcome the risk of ADE by instead using a lipid nanoparticle-encapsulated mRNA encoding the transcript for the internal structural nucleocapsid (N) FCoV protein. Both wild type and, by introduction of silent mutations, GC content-optimized mRNA vaccines targeting N were developed. mRNA durability in vitro was characterized by quantitative reverse-transcriptase PCR and protein expression by immunofluorescence assay for one week after transfection of cultured feline cells. Both mRNA durability and protein production in vitro were improved with the GC-optimized construct as compared to wild type. Immune responses were assayed by looking at N-specific humoral (by ELISA) and stimulated cytotoxic T cell (by flow cytometry) responses in a proof-of-concept mouse vaccination study. These data together demonstrate that an LNP–mRNA FIP vaccine targeting FCoV N is stable in vitro, capable of eliciting an immune response in mice, and provides justification for beginning safety and efficacy trials in cats.
Tequila Vinasse Treatment in Two Types of Vertical Downflow Treatment Wetlands (with Emergent Vegetation and Ligninolytic Fungi)
Authors: Ramírez-Ramírez Anderson A. , Lozano-Álvarez Juan A. , Gutiérrez-Lomelí Melesio , Zurita Florentina
Published: June 2024

The aim of this study was to evaluate and compare the efficiency of two types of vertical downflow wetlands (VDFWs) (with the presence of ligninolytic fungus Trametes versicolor and planted with Iris sibirica) for the treatment of tequila vinasses (TVs) as a secondary treatment; control systems with only a filter medium were also included. The systems operated with a 7-day run/resting mode of operation. Various water quality parameters were analyzed in both the influent and the effluents, namely total suspended solids (TSS), chemical oxygen demand (COD), biological oxygen demand (BOD5), total organic carbon (TOC), pH, electrical conductivity (EC), true color and turbidity, total phosphorus (TP), total nitrogen (TN), etc. The two types of VDFWs as well as the control treatment were effective in reducing the different pollutants (p < 0.05); however, planted systems showed a tendency toward higher efficiencies. With an influent concentration of 49,000 mg L−1 and an organic loading rate of 4942 g COD m−2d−1, the COD reduction was around 40% in the planted systems, while in the other two, the reduction was 35%. Furthermore, TSS removals were 36, 20 and 16% in the VDFWs with vegetation, ligninolytic fungus and control systems, respectively. These results suggest that the fungus Trametes versicolor did not develop the desirable enzymatic expression for pollutant removal, probably as a result of the absence of aerobic conditions in the systems. Therefore, more research is needed to achieve a better fungal performance in VDFWs.
Investigate the Spatiotemporal Evolution of Drought and Its Interaction with Atmospheric Circulation in the Yellow River Middle Basin
Authors: Dai Yuanxin , Dong Jinlong , Wei Yingnan , Xu Mengyuan , Javed Tehseen , Ayantobo Olusola Olaitan , Yao Ning , Hu Bao
Published: June 2024

Global warming contributes to an increased frequency and severity of droughts. Drought emerges as a highly prevalent natural calamity, distinguished by its formidable disruptive impact and the capacity to trigger considerable economic setbacks. Understanding the spatiotemporal characteristics of droughts and clarifying the driving role of atmospheric circulation on droughts is vital for agricultural, hydrological, ecological, and socio-economic systems. Leveraging meteorological data from 36 stations in the middle reaches of the Yellow River Basin from 1961 to 2020, we employed the Standardized Precipitation Evapotranspiration Index (SPEI) to calculate drought occurrence. Concurrently, we explored the influence of atmospheric circulation on the SPEI. The findings of our study underscore a concerning trend of worsening drought conditions within the study area. We discovered a significant correlation between the duration and severity of drought (R = 0.83, p < 0.001); longer durations often corresponded to higher levels of severity. Turning our attention to atmospheric dynamics, the Nino Eastern Pacific index (NE) emerged as a critical driver of SPEI dynamics (the contribution of NE to SPEI was 0.22), significantly impacting drought patterns. In conclusion, the study significantly contributes to our comprehension of the evolving drought patterns under the influence of global warming. The findings can provide valuable information for water resource management and drought disaster control.
Análise de Componentes Principais e Análises de Cluster como ferramentas para avaliar a qualidade de sobremesa láctea
Authors: Becker Gisele , Silva de Britto Gabriela Cristina , Nascimento Edgar , Faria Rozilaine A P G
Published: June 2024

Métodos de análise estatística devem auxiliar profissionais da área da indústria de alimentos a entender o comportamento de variáveis avaliadas durante a vida de prateleira de um produto. Assim, o objetivo do trabalho foi utilizar a Análise de Componentes Principais para verificar a correlação entre as variáveis físico-químicas de uma sobremesa láctea preparada com cúrcuma em diferentes concentrações e banana-da-terra. Foram avaliados os parâmetros pH, atividade de água, sinérese, sólidos solúveis, teor de carotenoides e oxidação lipídica. Os dados obtidos foram submetidos à ACP e ao dendograma de Cluster e correlação de Pearson. A partir desta correlação foi possível avaliar que a variável que exerceu mais influência na qualidade do produto lácteo foi a concentração do açafrão. Conclui-se que a correlação entre pH e oxidação lipídica e o método de análise estatística empregado permitiu identificar o comportamento de interação entre as variáveis, fenômeno de difícil observação ao se aplicar teste de média comumente aplicados.
Long-term outcomes of sacral neuromodulation for low anterior resection syndrome after rectal cancer surgery
Authors: de Miguel Valencia Mario J. , Marin Gabriel , Acevedo Ana , Hernando Ana , Álvarez Alfonso , Oteiza Fabiola , de Miguel Velasco Mario J.
Published: June 2024

Purpose: This study assessed the long-term outcomes and quality of life in patients who underwent sacral neuromodulation (SNM) due to low anterior resection syndrome (LARS).Methods: This single-center retrospective study, conducted from 2005 to 2021, included 30 patients (21 men; median age, 70 years) who had undergone total mesorectal excision with stoma closure and had no recurrence at inclusion. All patients were diagnosed with LARS refractory to conservative treatment. We evaluated clinical and quality-of-life outcomes after SNM through a stool diary, Wexner score, LARS score, the Fecal Incontinence Quality of Life (FIQL) questionnaire, and EuroQol-5D (EQ-5D) questionnaire.Results: Peripheral nerve stimulation was successful in all but one patient. Of the 29 patients who underwent percutaneous nerve evaluation, 17 (58.62%) responded well to SNM and received permanent implants. The median follow-up period was 48 months (range, 18–153 months). The number of days per week with fecal incontinence episodes decreased from a median of 7 (range, 2–7) to 0.38 (range, 0–1). The median number of bowel movements recorded in patient diaries fell from 5 (range, 4–12) to 2 (range, 1–6). The median Wexner score decreased from 18 (range, 13–20) to 6 (range, 0–16), while the LARS score declined from 38.5 (range, 37–42) to 19 (range, 4–28). The FIQL and EQ-5D questionnaires demonstrated enhanced quality of life.Conclusion: SNM may benefit patients diagnosed with LARS following rectal cancer surgery when conservative options have failed, and the treatment outcomes may possess long-term sustainability.
Using the Index Method in Analyzing Fertility in the Republic of Kazakhstan and Its Regions in 2009–2022
Authors: Shokamanov Y. K. , Demesinova A. A.
Published: June 2024

The present article covers key findings of the study aimed at proposing an index method for analyzing fertility in the Republic of Kazakhstan and its regions using official statistical information. The study's relevance arose from the fact that in the 1990s, Kazakhstan experienced a significant population decline due to migration outflow and a decrease in the birth rate. The strategy for development of the Republic of Kazakhstan until the year 2030 set the task of overcoming the trend of the population decline. An assertive demographic policy has become one of the country's long-term development strategies.The paper presents a methodology for estimating the increments of children born depending on the number of women of reproductive age, changes in age-related fertility rates, and structural shifts in the age groups of women. The developed methodology of the index analysis of fertility was tested, which made it possible to obtain new data on the dynamics of fertility in Kazakhstan and its regions from 2009 to 2022 and the influence of individual factors on it. Calculations showed that, in general, the number of children born was influenced mainly by age-related fertility rates and structural shifts in the ages of women of reproductive age.Significant differences in the dynamics and impact of individual factors were observed in the regions of Kazakhstan, which in the study were divided into four groups. This shall allow, later on, to carry out targeted demographic measures, taking regional characteristics into account and being mindful of the current demographic situation when planning socio-economic policy in the field of family and demography of the regions.
O episódio traumático do Fogo de 51 em Barra Velha / BA
Authors: Margon Massi Camila
Published: June 2024

O presente artigo busca analisar o episódio conhecido como Fogo de 51, uma ação violenta contra a população indígena Pataxó localizada no litoral do extremo sul da Bahia. Cenário resultante do processo de luta contra a desapropriação do Monte Pascoal, que foi elevado durante o período da Ditadura Estadonovista (1937 - 1945) ao status de Parque Nacional.  Utilizando-se da análise da obra Barra Velha: o último refúgio (1985), escrita em 1978 e publicada em 1985 a fim de instrumentalizar o conceito de Trauma proposto pelo historiador e teórico norte-americano Dominick LaCapra. Lançando mão também da utilização de periódicos baianos, como o jornal O Momento e A Tarde, além do periódico carioca Imprensa Popular e as reportagens que abordam o Fogo de 51.
Desenhos de um mapa global
Authors: Affortunati Martins Alessandra
Published: June 2024

O artigo trata de três diferentes mapas globais, cujos desenhos se estabelecem do início da modernidade até os dias atuais e, além disso, as razões sociopolíticas e econômicas que provocaram essas alterações das linhas globais. O objetivo é mostrar como entre os desenhos do desenvolvimentismo westfaliano e do neoliberalismo, o desenho fascista não figura como simples desvio na rota esclarecida que ideologicamente forma a modernidade. Após rascunhar esse grande mapa, mostra-se como atualmente o neofascismo reconfigurou as linhas que se estabeleceram após a Segunda Guerra Mundial com modelos de negócios bélicos nacionalistas. Outro aspecto se refere ao modo como esses desenhos modernos aqui mapeados e seus sistemas político-econômicos capitalistas correspondentes frequentemente cooptam parte de militâncias e de suas lutas político-sociais para reverter o aspecto moral de tais movimentos em sustentação de base para explorações de negócios em diferentes modalidades de interesses capitalistas. A contribuição desse artigo para o debate político contemporâneo é a de destituir da discussão uma faceta moralista para a análise das questões, devolvendo a estas a complexidade de suas formações sintomáticas. Com o quadro de problemas exposto nesse recorte mais denso fica claro que as soluções para enfrentar o neofascismo devem ser pensadas a partir de novos desenhos que escapem às formas (desenvolvimentismo westfaliano ou neoliberalismo) já desenhadas na modernidade.
Exiliarnos del Oriente y del Occidente
Authors: Bechara Edgardo
Published: June 2024

Conferencia pronunciada por Edgardo Bechara el 15 de diciembre de 2021 en la Universidad Federal de São Paulo. Publicado in memoriam.
Long-term pulmonary complications in sulfur mustard-exposed patients: gene expression and DNA methylation of OGG1
Authors: Zamani Mohammad Saber , Ghazanfari Tooba
Published: June 2024

Introduction: It is well established that tissues exposed to sulfur mustard (SM) generate high levels of reactive oxygen species. This leads to oxidative stress and, ultimately, damage to DNA molecules over the course of time. Additionally, SM, through its alkylating effects, is capable of directly damaging DNA on its own. In cells, these damages trigger a variety of DNA repair pathways, including the base excision repair (BER) pathway. Even so, in the long run, it remains unclear how the BER repair pathways will react. Methods: The purpose of this study was to assess the promoter DNA methylation and the mRNA expression of 8-oxoguanine glycosylase (OGG1), one of the key components of the BER pathway, in patient PBMCs that were exposed to SM 27 years ago using methylation-sensitive high resolution melting and qPCR. The study was conducted on three groups of participants exposed to SM with mild (n = 20), moderate (n = 24), and severe (n = 20) lung complications. Results: Our results showed significant OGG1 mRNA overexpression was observed in moderate groups compared to mild groups (P = 0.036). DNA methylation was also altered in mild-moderate and moderate-severe groups (P < 0.0001 and 0.023, respectively). Although aging was significantly associated with OGG1 mRNA expression, promoter DNA methylation of OGG1 was not associated with its mRNA expression. Conclusion: This study revealed differences in OGG1 mRNA expression and DNA methylation among the severity groups of long-term pulmonary complications associated with SM exposure. However, there was no correlation between OGG1 DNA methylation and mRNA expression. Therefore, it appears that other mechanisms may be contributing to the dysregulation of OGG1 mRNA expression.
Chondrogenic Potential of PMSCs Cultured on Chondroitin Sulfate/Gelatin -Modified DBM Scaffold
Authors: Haghwerdi Fatemeh , Haririan Ismaeil - , Soleimani Masoud
Published: June 2024

Introduction: Osteoarthritis is one of the most common orthopedic diseases that gradually causes wear and damage to the articular Subchondral bone due to the destruction of articular cartilage. One of the basic challenges in cartilage tissue engineering is the choice of scaffold. In the design of the cartilage scaffold, it is useful to consider parameters such as porosity, water absorption, high mechanical resistance, biocompatibility, and biodegradability. Therefore, in this study, Demineralized Bone Matrix (DBM) which inherently has these characteristics to some extent, was chosen as the basic scaffold. Methods: The Gelatin/demineralized bone matrix (G/DBM) and the Chondroitin sulfate- Gelatin/demineralized bone matrix (GCS/DBM) scaffolds were prepared, respectively by incorporating gelatin or Chondroitin sulfate/gelatin solution inside DBM pores, freeze-drying and crosslinking with EDC/NHS. The physicochemical, biological characteristics, and chondrogenic potential of scaffolds were studied. Results: According to the SEM results, the size of the DBM pores in the G/DBM and GCS/DBM scaffolds decreased (from almost, 100-1500 µm to less than 200 µm) which reduced cell escape compared to the DBM scaffold. Also, crosslinking the scaffolds has greatly increased their compressive E-modulus (more than 8 times). The cytocompatibility and non-toxicity of all scaffolds were confirmed by acridine orange/ethidium bromide (AO/EB) staining. The evaluation results of chondrogenic differentiation of placenta-derived mesenchymal stem cells (PMSCs) on modified scaffolds, using the Real-time PCR method, showed that the presence of CS in the GCS/DBM scaffold improved the expression of chondrogenesis markers such as Aggrecan (AGC) (~4 times) and collagen 2 (COL-2) (~ 2.2 times) compared to the DBM scaffold. Also, Alcian blue staining and immunohistochemical analyses of the scaffolds, respectively, showed a denser and more coherent synthesis of GAGs and COL-2 protein on the GCS/DBM scaffold than on the G/DBM and DBM. Conclusion: According to the obtained results, it seems that the GCS/DBM scaffold can be a suitable scaffold in cartilage tissue engineering.
Derrame pleural izquierdo por fístula de origen pancreático: reporte de caso clínico y revisión breve de literatura médica
Authors: Casares Fallas Daniel , Cerdas Azofeifa Cristhian , Castro Salazar Silvia , Mar´ín Zúñiga Josué , Balmaceda Meza Andrea
Published: June 2024

Entre las complicaciones más raras e infrecuentes de pancreatitis crónica se ubican las fístulas pancreáticas-pleurales, estas se presentan en un 0.04% de la población con esta comorbilidad. Se describe un caso clínico de un masculino de 59 años con antecedente de pancreatitis aguda a repetición, quien inicia con cuadro de dificultad respiratoria aguda de 2 meses de evolución asociado con derrame pleural izquierdo masivo. Se realiza toracocentesis para drenar aproximadamente 2500 ml de líquido de tipo exudativo y, además, se evidencia coinfección por pseudomona putida en cultivo de líquido pleural, la cual se cubre con meropenem 500 mg cada 8 horas IV por 14 días. Posteriormente, se realiza una tomografía axial computarizada (TAC) abdominal sin medio de contraste intravenoso que evidencia pseudoquiste pancreático y colangiopancreatoresonancia (CPRE) que exhibe un pancreatograma anormal con fuga de medio de contraste entre cabeza y cola pancreática por lo que se colocó stent en vía pancreático-biliar.
Rabia: una zoonosis que persiste en el siglo XXI
Authors: García Quirós Christian , Navarro María José
Published: June 2024

La rabia fue descrita desde 2300 a. C. y actualmente es la causa de muerte de aproximadamente 60 000 personas en el mundo al año, principalmente en el continente asiático y africano. Es un virus ARN, neurotropo, de la familia Lyssavirus. Se considera una enfermedad zoonótica, transmitida principalmente por perros y murciélagos. Al ser un virus con tropismo neurológico, viaja retrógradamente hasta el sistema nervioso central. Las manifestaciones clínicas se presentan según los nervios a los que se disemina. Si afecta las glándulas salivales, logra transmitirse a otros organismos y perpetuar su ciclo.  
Su periodo de incubación oscila entre dos semanas y siete años. Abarca la fase de incubación, prodrómica y neurológica aguda. El espectro clínico neurológico es amplio; destaca la encefalitis, hidrofobia y aerofobia. Además, puede presentar episodios paralíticos que desencadenan la muerte.
Por otro parte, el diagnóstico se confirma por pruebas de laboratorio. Incluso, en muchas ocasiones el diagnóstico de certeza se establece post mortem con muestras del tejido cerebral.
Hoy en día no se ha descrito un medicamento que revierta la totalidad de la sintomatología. Sin embargo, se han documentado métodos como la profilaxis pre y post exposición. Asociado a ello, hace casi dos décadas se implementó el protocolo Milwaukee; lineamiento con el que la paciente inicial sobrevivió, pero con importantes secuelas neurológicas.
Cabe recalcar que la rabia se busca erradicar por medio de la vacunación. Por lo que es fundamental hacer consciencia sobre los beneficios de esta. Por lo que el objetivo de esta revisión es actualizar y dar a conocer al lector información concisa y relevante sobre la rabia.
Efectos de la pandemia COVID-19 en el estado de salud de adultos mayores con enfermedades no transmisibles, Ecuador-2022
Authors: Amaguaña Paredes Nathaly Lizeth , Reascos Paredes Yu Ling
Published: June 2024

La Organización Mundial de la Salud declaró una emergencia global el 30 de enero de 2020 por la variante SARSCOV-2, que afectó a millones de personas en todo el mundo debido al aumento de la mortalidad en personas con enfermedades no transmisibles (ENT). El objetivo de este artículo es determinar los efectos de la pandemia por la COVID- 19 en el estado de salud de los adultos mayores con ECNT. El enfoque es cuantitativo, con un diseño no experimental, transversal de tipo descriptivo de campo; se consideró a la población total como fuente de recolección de datos conformada por 64 personas con ENT que pertenecen a un club de adultos mayores, se utilizó el instrumento validado cuestionario SF36 que evalúa el estado de salud. Dentro de  los datos sociodemográficos los adultos mayores son de 65 a 97 años, 59,4% de sexo femenino, 45.3% con nivel de ingresos bajos. Durante el confinamiento 51.6% de adultos mayores tuvieron un estado de salud general deteriorado, 26,6% posee rol físico malo, 39,1% nivel de función social baja, 31.3% con problemas de salud mental. Como conclusión se evidencian los efectos de la pandemia en la población de estudio tuvieron un impacto negativo en la salud física, mental y social, su vulnerabilidad no se debe solo a la edad, sino también a la situación económica, baja educación, no contar con un rol social y vivir con ENT, con el consecuente deterioro de las funciones de la vida diaria y su independencia.
Aplicación de la inteligencia artificial en la salud pública para el diagnóstico temprano y tamizaje de enfermedades oncológicas
Authors: Ketelhohn Hans Werner , Meza Fabiola , Aguilar Charlotte , Barrantes Kamila , Ibañez Sandra
Published: June 2024

Actualmente, la inteligencia artificial (IA) es una gran contribución en el ámbito de la medicina, brindando un análisis de ciertos algoritmos para dar soluciones alternativas en el diagnóstico temprano, tratamiento y pronóstico de diferentes enfermedades. El diagnóstico certero con respecto a las enfermedades oncológicas es parte de un proceso largo y complejo por lo que, implementando los avances desarrollados con la IA, se favorece la detección temprana y, por ende, se brinda un apoyo más efectivo a los pacientes con mejores expectativas en el abordaje. En esta revisión, se describen varios ejemplos recientes sobre la aplicación de la IA y el impacto que esta genera sobre el diagnóstico de enfermedades oncológicas. De igual forma, se destacan ciertos obstáculos, recursos y conjuntos de datos que pueden ayudar a aprovechar el uso de la IA. El desarrollo continuo y aplicación de la IA dará origen a importantes cambios en relación con la oncología. Con esto podemos concluir que la IA es una herramienta de mucha utilidad a la hora del tamizaje y diagnóstico de las enfermedades oncológicas.
Modeling of magnetoelectric material for antennas
Authors:   Yaroslav-the-Wise Novgorod State University, Petrov R. V. , Nikitin A. O. ,   Yaroslav-the-Wise Novgorod State University, Zakharov M. A. ,   Yaroslav-the-Wise Novgorod State University, Eminov S. I. ,   Yaroslav-the-Wise Novgorod State University
Published: June 2024

The paper is devoted to the modeling of magnetoelectric material for antennas. The effect observed in magnetoelectric gradient structures is discussed. Gradient magnetoelectric structures are a new type of composite structures consisting of a magnetoelectric material and an artificial dielectric. A new principle of controlling the antenna wave properties based on the geometric displacement of the excitation point due to the application of an external electric field is being considered. The use of an artificial dielectric in a multiferroid structure will make it possible to more flexibly control the areas of conversion of a magnetostatic surface wave into an electromagnetic wave, which in practical terms will give new opportunities for controlling the characteristics of antennas. The conclusion about the possibility of controlled conversion of a magnetostatic surface wave into an electromagnetic wave was obtained as a result of calculations based on the developed model by selecting the values of stationary magnetic and electric fields, and the values of the permittivity of the artificial dielectric layer
Operator equation of diffraction on a segment of a circular cylinder
Authors:   Yaroslav-the-Wise Novgorod State University, Eminov S. I. , Sochilin A. V. ,   Yaroslav-the-Wise Novgorod State University, Petrov R. V. ,   Yaroslav-the-Wise Novgorod State University, Zakharov M. A. ,   Yaroslav-the-Wise Novgorod State University
Published: June 2024

A new, mathematically efficient method for solving the vector equation of diffraction on an open surface of rotation is proposed. The method is based on the allocation of the main operator, the definition of functional spaces and the reduction of the operator equation to the Fredholm equation of the second kind. Sobolev spaces are used as ones that take into account the Meixner condition on the edge. In the selected spaces, the main operator is bounded and invertible; the inverse operator is also bounded. A projection method for solving operator equations has been developed.
Whole Genome Sequencing Of L.Monocytogenes And L.Innocua : A Basis For Comparative Genomics Of The Genus Listeria
Authors:   ,   Cork Institute of Technology, Purcell Rachel
Published: June 2024

Listeria monocytogenes is a gram-positive, food-borne human and animal pathogen. L.innocua is a non-pathogenic species the most closely related to L. monocytogenes. Comparative genomics between a pathogenic and a closely related non-pathogenic species is a powerful approach for identifying genes or regions on the chromosome, which might be involved in virulence. Therefore whole genome sequencing of these two organisms was undertaken. The strategy used was based on a random approach combined with end-sequencing of a medium insert library for the finishing phase. Based on the available sequence data for these two species an in silico analysis for the presence of genes putatively coding for internalins was undertaken. This analysis identified several genes homologous to the internalin coding sequences which are known virulence determinants of L. monocytogenes and also more than forty genes with an LPxTG anchor motif which is a feature of some cell wall associated proteins of gram positive organisms e.g. Internalins. Comparative in silico analysis of the two partially sequenced genomes revealed that certain of these genes are specific to the pathogenic L.monocytogenes and some to the non-pathogenic L.innocua. To investigate their distribution among the genus Listeria, amplification of these genes using the Polymerase Chain Reaction was carried out. This revealed a large degree of diversity within this protein family among the different species. Furthermore, three genes specific to L.monocytogenes, and two, specific to apathogenic species of Listeria were identified.
Dynamic Performance Of Isolated Power Converters
Authors:   ,   Cork Institute of Technology, Badia David
Published: June 2024

"Isolated power converters are primarily used in applications where electrical galvanic isolation is required for safety purposes. They are also used in applications, which require various output voltages level. They have been studied from many different aspects, but in this thesis the fundamental circuits of the flyback, the forward and the half-bridge converters are studied and compared extensively, with regard to their dynamic performance. This analysis will lead us to a better understanding of their behaviour, that is a crucial point in the selection of each topology for a particular application. Moreover, the dynamic response of each converter is different; this aspect is investigated as well. An analysis of the behaviour and the dynamic response of each topology operating in both, the continuous and the discontinuous conduction mode of operation is presented. This is done by modelling the primary parasitic elements of the converter components to obtain as faithful as possible responses that correspond with the real case. The steady-state dc voltage conversion ration, and the small-signal ac control to output and the small-signal ac line to output transfer functions Bode diagrams response of the three converters, m both modes of conduction, are presented. Our analysis utilises Maple and Matlab, to obtain the state descriptions of the converters and then calculates the average plant response in the two different modes of operation. A unique table is presented which contrasts and compares the small-signal ac transfer functions of each of the topologies in ideal and non-ideal situations, in a coherent and user friendly manner."
paso del Instituto Tecnológico del Sur a la Universidad de la Libertadora (Bahía Blanca, 1956-1960)
Authors: Aveiro Coppolino Martin
Published: June 2024

Nos proponemos indagar en la transición institucional que atravesó los primeros años de la Universidad Nacional del Sur (UNS) -1956-1960- después del golpe de Estado de 1955 denominado Revolución Libertadora, la cual fue cimentada sobre la base del precursor Instituto Tecnológico del Sur (ITS), fundado en 1947 por el peronismo. De modo de comprender el entramado de relaciones y diferenciaciones entre una y otra institución a partir de las trayectorias particulares de intelectuales o científicos que transitaron por la casa de estudios
de la ciudad de Bahía Blanca. En síntesis, en este artículo vamos a examinar las continuidades y discontinuidades o sus diversos grados de resquebrajamiento en sus representaciones, ideologías y objetivos a partir de su drástica reestructuración y los intentos de eliminación de su pasado inmediato. Para ello, analizaremos fuentes documentales, entrevistas orales y bibliografía específica que trata el período para contrastarla con las miradas históricas oficiales que reconstruyen su pasado sin inmutarse del todo ante la ruptura que significó el traspaso institucional entre el ITS y la UNS. De cierta manera, esas interpretaciones, ocultan más que develan la trama profunda de situaciones, relaciones, articulaciones, quiebres y fisuras con las cuales se constituyó la Universidad creada por la Revolución Libertadora.
¿Qué implica enseñar derechos humanos en el nivel superior? Reflexiones a partir de la experiencia de profesoras/es formadoras/es de maestras/os
Authors: Santos Julieta Elizabeth
Published: June 2024

En este trabajo, presentamos un conjunto de reflexiones sobre las concepciones que profesoras/es formadoras/es de docentes portan respecto de la enseñanza de los Derechos Humanos. Los datos surgen de las entrevistas semi-estructuradas realizadas a docentes de nivel superior donde nos enfocamos en sus experiencias y concepciones en el contexto de las prácticas de la enseñanza en DDHH que estos/as llevan adelante. Para ello realizamos un trabajo hermenéutico sobre las entrevistas, considerando como ejes de análisis: i) los enfoques en la enseñanza de los Derechos Humanos en el nivel superior, y, ii) la programación didáctica de los Derechos Humanos en la formación docente. La estrategia teórico-metodológica se enmarca en la investigación educativa socio-crítica, mediante un diseño flexible, técnicas de recolección y análisis de información cualitativa, y análisis cualitativo de contenidos. Hacia el final, recuperamos algunos núcleos problemáticos vinculados con la enseñanza de los Derechos Humanos en la formación docente y señalamos la necesidad de revisar su abordaje en la formación de los futuras/os maestras/os de nivel primario desde una perspectiva crítica, analizando los desafíos pedagógicos, didácticos, epistemológicos y políticos que implica.
Presencia y Acción Misionera de la Vida Consagrada Femenina en Bolivia (1655 - 2023)
Authors:   Universidad Católica Boliviana San Pablo, García Riveros Karina
Published: June 2024

El documento aborda la presencia y acción misionera de la vida consagrada femenina en Bolivia, destacando la labor de 401 congregaciones según el Censo de 2017. Estas congregaciones realizaron obras sociales como educación, salud, acompañamiento a víctimas de violencia, entre otras. El libro "Presencia y Acción Misionera de la Vida Consagrada Femenina en Bolivia (1655 – 2023)" ofrece una visión detallada de la vida espiritual, relacional y evangélica de estas mujeres. Se destaca su compromiso en áreas rurales, enfrentando desafíos históricos y coyunturales del país. El estudio refleja la importancia de su labor en la sociedad boliviana.
"Du bist nicht so einer, der sich jetzt irgendwo ausheulen gehen muss". Von der Notwendigkeit einer klassismuskritischen Etablierung der Schulsozialarbeit
Authors: Eidemann Jacqueline , Bräulich Pierre
Published: June 2024

Der Beitrag greift die Rolle von Schulsozialarbeit als wesentliche unterstützende Akteurin im Kontext schulischer Berufsorientierung und Übergangsgestaltung auf. Die Autor*innen zeigen auf, dass Schulsozialarbeit in ihrer institutionellen Einbettung eine durchaus ambivalente Rolle hat, indem sie einerseits unterstützend wirkt und andererseits Ungleichheitsdimensionen reproduziert sowie ‚Unterstützungswürdigkeit‘ herstellt. Wie junge Erwachsene mit den daraus erwachsenden Adressierungen umgehen, illustrieren empirische Beispiele. (DIPF/Orig.)