bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanisms and treatment of painful neuromas
Authors: Lu Changfeng , Sun Xun , Wang Chong , Wang Yu , Peng Jiang
Published: January 2018

A painful neuroma is a common complication of a peripheral nerve injury or amputation, and it can cause tremendous pain that is resistant to most analgesics. Furthermore, painful neuromas have a high postoperative recurrence rate. Painful neuromas are often accompanied by functional disorders, drastically reducing the patient’s quality of life. Several pathophysiological mechanisms have been proposed to explain this type of neuropathic pain, including peripheral and central sensitisation and the involvement of nerve growth factor, α-smooth muscle actin, the cannabinoid CB2 receptor and structural changes in neuroma fibres. Nevertheless, the mechanisms of neuroma-associated pain are not fully understood, contributing to the challenge of managing patients with painful neuromas. There are several effective treatment methods, although none are universally accepted. This review summarises the common mechanisms and treatments of painful neuromas, attempting to link the mechanisms and treatments. We hope to provide useful guidelines for choosing the appropriate treatment for the management of painful neuromas.
Bioproducts from Potatoes. A Review
Authors: Priedniece Vivita , Spalvins Kriss , Ivanovs Kaspars , Pubule Jelena , Blumberga Dagnija
Published: January 2018

The increasing amount of food waste througout the world is becoming a major problem for waste management plants. The food waste produced amounts to 1.3 million tons a year. This is a resource that could be used for production of new products. Decreasing fossil resources and a rapidly growing population lead to the necessity to produce more food and to replace existing with new materials ones that are biological and produce little effect on environment. Bioeconomy is a method that can help achieve production of value-added products that use local resources and waste to manufacture products efficiently. In this article, we are looking at possibilities to use potatoes for production of new materials, such as bioplastics, antioxidants, proteins, instead of their conventional use for food production. We have studied potato components, extraction technologies and summed up possible directions for development for new products, looking at the use of processing waste as a raw material.
Factors blocking the development of north – central Rzeszów
Authors: Rybka Adam , Mazur Rafał
Published: January 2018

Rzeszów is one of the best developing cities in Poland. Once the small HQ of a principality - due to complicated historical conditioning - it has now become a place where an increasing number of people choose to live. The city with its bursting life, streets and squares starts and ends, however, in an area which only a few dozen years ago still catered for one fifth of the current population. The main reason for this phenomenon is the presence of spatial barriers, which significantly limit the development of the central urban area. This article analyzes the elements, which block the development of the north-central part of Rzeszów. An appropriate diagnosis of the problem may in the future allow the right actions in urban planning to be taken in order to cross these barriers. This may lead to the future development of areas with huge urbanization potential. Investments undertaken by city authorities to develop the northern peripheries of Rzeszów may trigger the development of the central district in this direction. This may occur as a result of concrete design interventions. The new part of the central district should have the scale and proportions of urban space that answer to the needs of a dynamically developing capital of the Podkarpacie region.
Economic efficiency of application of solar window
Authors: Shapoval Stepan
Published: January 2018

Priority and qualitatively new direction in the fuel and energy sector is renewable energy. This paper describes a feasibility study of using solar window in the system of solar heat supply. The article presents literature data about the effectiveness of the use of solar systems in other countries. The results confirm a sufficient efficiency of solar heat supply with using solar Windows. Insights based on practical experience and mathematical calculations, which are aimed at a detailed explanation of economic efficiency of the proposed construction.
Numerical modelling of the reinforced concrete influence on a combined system of tunnel support
Authors: Grujić Bojana , Jokanović Igor , Grujić Žarko , Zeljić Dragana
Published: January 2018

The paper presents the experimental, laboratory determined rheological-dynamic analysis of the properties of fiber reinforced concrete, which was then utilized to show nonlinear analysis of combined system of tunnel support structure. According to the performed experiments and calculations, different processes of destructive behavior of tunnel lining were simulated in combination with elastic and elastic-plastic behavior of materials taking into account the tunnel loading, the interaction between the fiber reinforced concrete and soil, as well as the interaction between the fiber reinforced concrete and the inner lining of the tunnel.
Possibility of heat recovery from gray water in residential building
Authors: Mazur Aleksandra , Słyś Daniel
Published: January 2018

Recovery of waste heat from gray water can be an interesting alternative to other energy saving systems in a building, including alternative energy sources. Mainly, due to a number of advantages including independence from weather conditions, small investment outlay, lack of user support, or a slight interference with the installation system. The purpose of this article is to present the financial effectiveness of installations which provide hot, usable water to a detached house, using a Drain Water Heat Recovery (DWHR) system depending on the number of system users and the various combinations of bathing time in the shower, which has an influence on the daily warm water demand in each of the considered options. The economic analysis of the adopted installation variants is based on the Life Cycle Cost (LCC) method, which is characterized by the fact that it also includes the operating costs in addition to the capital expenditure during the entire analysis period. For each case, the necessary devices were selected and the cost of their installation was estimated.
Quaternized Zn(II) phthalocyanines for photodynamic strategy against resistant periodontal bacteria
Authors: Kussovski Vesselin , Mantareva Vanya , Durmuş Mahmut , Angelov Ivan
Published: January 2018

Photodynamic inactivation (PDI) has been featured as an effective strategy in the treatment of acute drug-resistant infections. The efficiency of PDI was evaluated against three periodontal pathogenic bacteria that were tested as drug-resistant strains. In vitro studies were performed with four water-soluble cationic Zn(II) phthalocyanines (ZnPc1–4) and irradiation of a specific light source (light-emitting diode, 665 nm) with three doses (15, 36 and 60 J/cm2). The well detectable fluorescence of ZnPcs allowed the cellular imaging, which suggested relatively high uptakes of ZnPcs into bacterial species. Complete photoinactivation was achieved with all studied ZnPc1–4 for Enterococcus faecalis (E. faecalis) at a light dose of 15 J/cm2. The photodynamic response was high for Prevotella intermedia (P. intermedia) after the application of 6 μM of ZnPc1 and a light dose of 36 J/cm2 and for 6 μM of ZnPc2 at 60 J/cm2. P. intermedia was inactivated with ZnPc3 (4 log) and ZnPc4 (2 log) with irradiation at an optimal dose of 60 J/cm2. Similar photoinactivation results (2 log) were achieved for Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) treated with 6 μM ZnPc1 and ZnPc2 at a light dose of 60 J/cm2. The study suggested that PDI with quaternized Zn(II) phthalocyanines and specific light irradiation appears to be a very useful antimicrobial strategy for effective inactivation of drug-resistant periodontal pathogens.
Effects of Cosolvents and Macromolecular Crowding on the Phase Transitions and Temperature-Pressure Stability of Chiral and Racemic Poly-Lysine
Authors: Knop Jim-Marcel , Winter Roland
Published: January 2018

FTIR spectroscopy has been used to reveal the effects of different types of cosolvents (TMAO, urea) as well as macromolecular crowding (using the crowding agent Ficoll) on the temperature and pressure dependent structure of poly-L-lysine, poly-D-lysine and their racemic mixture. Compared to the effects of cosolvents on the unfolding transition of proteins, their effects on the α-helix to aggregated β-sheet transition of polylysine are quite small. High hydrostatic pressure has been found to favor the α-helical state over the aggregated β-sheet structure which is reflected in a volume decrease of ΔV=−32 mL mol−1, indicating that the packing mode is more efficient in the α-helical structure. Both, addition of urea and TMAO lead to a decrease in pressure stability of the aggregated β-sheet structure, which is accompanied by a three-fold decrease in ΔV, whereas the macromolecular crowder has little effect on the β-to-α transition. The more than 3 kbar higher β-to-α transition pressure of the racemic mixture compared with PLL confirms the drastic stabilization of β-sheet aggregates if the stereoisomers PLL and PDL are combined. Changes in hydration and packing of the polypeptide occurs upon interaction and fine packing of the polypeptide’s chains of opposed chirality, which are slightly modulated by the properties of cosolute and crowding, only. The underlying solvational and packing mechanisms observed here may be decisive factors responsible for the spontaneous protein aggregation in general and, as such, may shed additional light on the molecular basis of amyloid-associated diseases.
Abdominal Vagal Afferents Modulate the Brain Transcriptome and Behaviors Relevant to Schizophrenia
Authors: Klarer Melanie , Krieger Jean-Philippe , Richetto Juliet , Weber-Stadlbauer Ulrike , Günther Lydia , Winter Christine , Arnold Myrtha , Langhans Wolfgang , Meyer Urs
Published: January 2018

Reduced activity of vagal efferents has long been implicated in schizophrenia and appears to be responsible for diminished parasympathetic activity and associated peripheral symptoms such as low heart rate variability and cardiovascular complications in affected individuals. In contrast, only little attention has been paid to the possibility that impaired afferent vagal signaling may be relevant for the disorder's pathophysiology as well. The present study explored this hypothesis using a model of subdiaphragmatic vagal deafferentation (SDA) in male rats. SDA represents the most complete and selective vagal deafferentation method existing to date as it leads to complete disconnection of all abdominal vagal afferents while sparing half of the abdominal vagal efferents. Using next-generation mRNA sequencing, we show that SDA leads to brain transcriptional changes in functional networks annotating with schizophrenia. We further demonstrate that SDA induces a hyperdopaminergic state, which manifests itself as increased sensitivity to acute amphetamine treatment and elevated accumbal levels of dopamine and its major metabolite, 3,4-dihydroxyphenylacetic acid. Our study also shows that SDA impairs sensorimotor gating and the attentional control of associative learning, which were assessed using the paradigms of prepulse inhibition and latent inhibition, respectively. These data provide converging evidence suggesting that the brain transcriptome, dopamine neurochemistry, and behavioral functions implicated in schizophrenia are subject to visceral modulation through abdominal vagal afferents. Our findings may encourage the further establishment and use of therapies for schizophrenia that are based on vagal interventions.

SIGNIFICANCE STATEMENTThe present work provides a better understanding of how disrupted vagal afferent signaling can contribute to schizophrenia-related brain and behavioral abnormalities. More specifically, it shows that subdiaphragmatic vagal deafferentation (SDA) in rats leads to (1) brain transcriptional changes in functional networks related to schizophrenia, (2) increased sensitivity to dopamine-stimulating drugs and elevated dopamine levels in the nucleus accumbens, and (3) impairments in sensorimotor gating and the attentional control of associative learning. These findings may encourage the further establishment of novel therapies for schizophrenia that are based on vagal interventions.
Microalgal community structure and primary production in Arctic and Antarctic sea ice: A synthesis
Authors: van Leeuwe Maria A. , Tedesco Letizia , Arrigo Kevin R. , Assmy Philipp , Campbell Karley , Meiners Klaus M. , Rintala Janne-Markus , Selz Virginia , Thomas David N. , Stefels Jacqueline
Published: January 2018

Sea ice is one the largest biomes on earth, yet it is poorly described by biogeochemical and climate models. In this paper, published and unpublished data on sympagic (ice-associated) algal biodiversity and productivity have been compiled from more than 300 sea-ice cores and organized into a systematic framework. Significant patterns in microalgal community structure emerged from this framework. Autotrophic flagellates characterize surface communities, interior communities consist of mixed microalgal populations and pennate diatoms dominate bottom communities. There is overlap between landfast and pack-ice communities, which supports the hypothesis that sympagic microalgae originate from the pelagic environment. Distribution in the Arctic is sometimes quite different compared to the Antarctic. This difference may be related to the time of sampling or lack of dedicated studies. Seasonality has a significant impact on species distribution, with a potentially greater role for flagellates and centric diatoms in early spring. The role of sea-ice algae in seeding pelagic blooms remains uncertain. Photosynthesis in sea ice is mainly controlled by environmental factors on a small scale and therefore cannot be linked to specific ice types. Overall, sea-ice communities show a high capacity for photoacclimation but low maximum productivity compared to pelagic phytoplankton. Low carbon assimilation rates probably result from adaptation to extreme conditions of reduced light and temperature in winter. We hypothesize that in the near future, bottom communities will develop earlier in the season and develop more biomass over a shorter period of time as light penetration increases due to the thinning of sea ice. The Arctic is already witnessing changes. The shift forward in time of the algal bloom can result in a mismatch in trophic relations, but the biogeochemical consequences are still hard to predict. With this paper we provide a number of parameters required to improve the reliability of sea-ice biogeochemical models.
İNSAN SERMAYESİ ÖZÜMSEME KAPASİTESİ VE YENİLİK PERFORMANSI İLİŞKİSİ
Authors: ÇETİN Sabahattin , FİDAN Yahya
Published: January 2018

Bu çalışmanın amacı insan sermayesi, özümseme kapasitesi ve yenilik performansı ilişkisinin incelenmesidir. Araştırma verileri İstanbul ve Ankara illerindeki teknoloji geliştirme bölgesinde faaliyette bulunan işletmelerden toplanmıştır. Araştırma sonuçlarına göre insan sermayesi ve özümseme kapasitesi, ürün ve süreç yeniliğini istatistiki açıdan anlamlı ve pozitif bir biçimde etkilemektedir. Ayrıca insan sermayesi özümseme kapasitesini de anlamlı bir şekilde etkilemektedir. Özümseme kapasitesinin insan sermayesi ile yenilik performansı arasındaki aracılık etkisine yönelik yapılan analizler sonucunda ise özümseme kapasitesinin insan sermayesi ile ürün ve süreç yeniliği arasında kısmi aracılık yaptığı belirlenmiştir.
SİYASİ PARTİLERİN MARKA KONUMLANDIRMA FAALİYETLERİ ÜZERİNE BİR UYGULAMA: GAZİANTEP ÖRNEĞİ
Authors: DEMİRAĞ Bülent , TAN Ahmet
Published: January 2018

Siyasal pazarlamada amaç, seçmen ihtiyaç ve isteklerinin doğru tespit edilebilmesi, seçmenlere yönelik politikalar oluşturulması, uygulanması ve en nihayetinde siyasal süreçte sürdürülebilir bir seçmen memnuniyeti ve buna bağlı olarak seçmen sadakati oluşturulabilmesidir. Özellikle, aldığı oy oranına bakılmaksızın seçimlerde ikinci olan partinin seçimi kaybetmiş sayıldığı ve bu nedenle rekabetin acımasız boyutlarda yaşandığı politize oranı yüksek toplumlarda, rakiplerden farklılaşarak ön plana çıkmak siyasetin uygulayıcı aktörlerinden olan siyasal partiler için son derece önemlidir. Bu farklılaşmanın yaratılabilmesi için rakiplerin, pazarın ve diğer değişkenlerin iyi analiz edilmesi, pazarın bölümlendirilmesi, konumlandırmaya bağlı politikaların ve rekabete bağlı stratejilerin oluşturulması ve uygulanması çok önemlidir.Çalışmanın amacı, seçmenlerin, siyasi parti tercihlerinde etkisi olduğu düşünülen özelliklere ilişkin algılarının ölçülmesidir. Bu kapsamda belirlenen 11 değişik özelliğin seçmenlerin demografik özellikleri ile anlamlı bir farklılık oluşturup oluşturmadığı incelenmiştir. Bu özelliklerin ve önem derecelerinin belirlenmesi, siyasi partilerin konumlandırma stratejileri oluşturmalarında önemli avantajlar sağlayacaktır. Bu kapsamda, Gaziantep ilinde oy kullanan seçmenlerden yüz yüze anket tekniği ile veriler toplanmıştır. Elde edilen veriler istatistiki analizlere tabi tutulmuştur. Bu kapsamda, siyasi parti seçimini etkileyen faktörlerin demografik kriterlerle anlamlı farklılık gösterdiği sonucuna varılmıştır.
INVESTIGATION OF THE EFFECTS OF THE HEALTH TRANSFORMATION PROGRAM ON PUBLIC HOSPITALS AND HEALTH PROFESSIONALS (RESEARCH IN ANKARA PROVINCE)
Authors: TEKİN Kemal , BIYIK Erhan
Published: January 2018

AIM: The aim of this study is to investigate the effects of health applications of the Health Transformation Program (HTP) on public hospitals and health professionals.MATERIALS AND METHODS: This descriptive and seeking relations study was conducted with the health professionals who were working in 4 public hospitals located in Ankara province. The survey was administered to 335 health professionals by using stratified sampling method. Frequency analysis, factor analysis, correlation, and regression analysis methods were used to analyze the data.RESULTS: Independent variables were infrastructure, health care delivery, and management. Dependent variables were digital displays and health professional variables. Two different regression models were developed. Multiple regression models which were designed for independent and dependent variables were statistically significant. Independent variables explained almost 14% of the total variance of the digital displays and 33% of the variance of the health professionals. CONCLUSION: The management and the representation of the health services are important forecasting tools for digital displays. However, the infrastructure of the health care does not have a significant effect. On the other hand, all of the independent variables are significant forecasting tools for health professionals and the Health Transformation Program (HTP) affects the health professionals more than public hospitals.
THE EFFECTS OF INTERNAL MARKETING ON ORGANIZATIONAL TRUST: A RESEARCH IN HOTEL INDUSTRY
Authors: KESEN Mustafa , TURAN Pınar Mutlu , KUTAY Naciye
Published: January 2018

The aim of this study is to determine how internal marketing would affect trust in the organization and trust in the executive dimensions of organizational trust. The study population consists of employees working in hotels operating in the town of Kuşadası in the province of Aydın, one of the oldest touristic regions of Turkey. For this purpose, a survey application was carried out on 148 employees of 7 hotels in total. The acquired survey data was evaluated via confirmatory factor analyses, reliability analyses, correlation analyses and regression analyses. According to the findings obtained from the research, internal marketing affects trust in the manager and trust in the organization positively. Despite some limitations, the research findings are considered to present some important assistance to the managers, employees and researchers.
HASTALARIN HALKLA İLİŞKİLER FAALİYETLERİNE BAKIŞ AÇILARININ İNCELENMESİ
Authors: GÖKTAŞ Bayram , YEŞİLAYDIN Gözde , ÖZKAN Okan
Published: January 2018

Bu araştırma, Türkiye’nin Doğu Anadolu Bölgesi’ndeki bir ilde faaliyet gösteren bir kamu hastanesinde halkla ilişkiler faaliyetlerinin işleyişini ve halkın bu konuya ilişkin bakışını saptamak, halkla ilişkiler faaliyetlerinin işlevini ve önemini vurgulamak, hastaların sağlık personeli ile ilgili görüşlerini öğrenmek ve konuya ilişkin öneriler geliştirmek amacıyla planlanmış betimleyici bir çalışmadır.İlgili hastaneye bir hafta içinde başvuran hasta sayısı yaklaşık 150 olup; çalışma kapsamında araştırmaya katılmak isteyen 99 hastaya anket uygulanmıştır. Verilerin toplanmasında Bahadır (2010) tarafından hazırlanan anket formu kullanılmıştır. Hastaların ilk iletişim kurdukları hastane personeli %56,6 ile hasta kabul birimi çalışanları; en rahat iletişim kurdukları hastane personeli (% 42,4) ise doktorlardır. Katılımcıların % 81,8’i hastane içinde herhangi bir sorun yaşadıklarında nereye başvuracaklarını bildiğini, % 50,5’ i şikayetlerini başhekime bildirmeyi tercih ettiklerini belirtmişlerdir. Katılımcıların % 52,5’i hasta kabul personelinin davranışlarından çok memnun; % 51,5’i danışma – yönlendirme birimindeki bilgilendirmeden memnundur. Araştırma sonucunda hastaların, hastane uygulamalarından genel olarak memnun oldukları saptanmıştır.
TÜRKİYE’DE FAALİYETTE BULUNAN BÜYÜK HAVALİMANLARININ İÇ VE DIŞ HAT PERFORMANSLARININ KARŞILAŞTIRILMASI
Authors: ÇINAROĞLU Eda , AVCI Tunahan
Published: January 2018

Bu çalışmada, Türkiye’de faaliyette bulunan büyük havalimanlarının iç ve dış hatlarda göstermiş oldukları performans düzeylerinin karşılaştırılması amaçlanmıştır Bunun için, çalışmada 2015-2016 yıllarına ait büyük havalimanı verileri kullanılarak, bu havalimanlarının etkinlik ve verimlilikleri araştırılmıştır. Etkinlik ölçümü ile havalimanlarının kendi aralarındaki, verimlilik ölçümü ile ise bir havalimanının önceki döneme göre performans düzeyi kıyaslanmaktadır. Yöntem olarak Veri Zarflama Analizi  (VZA) tercih edilmiştir. Veri olarak üç adet girdi değişkeni (personel sayısı, terminal alanı ve uçak kapasitesi) ile iki adet çıktı değişkeni (yolcu sayısı, yük trafiği) kullanılmıştır. Analiz sonuçlarına göre,  iç hatlarda her iki yılda da tam etkin olan havalimanları İstanbul Atatürk ve Adana havalimanlarıdır. Dış hatlarda ise, her iki yılda da İstanbul Atatürk ve Antalya havalimanlarının etkin olduğu belirlenmiştir. İç hatlarda en yüksek verimliliğe Trabzon havalimanının, en düşük verimliliğe Diyarbakır havalimanının sahip olduğu gözlenmiştir. Dış hatlarda ise en yüksek verimliliğe sahip havalimanı Mardin havalimanı iken, en düşük verimliğe sahip havalimanı Diyarbakır havalimanı olmuştur.
YÖNETİM KURULU YAPISI VE KÂR YÖNETİMİ UYGULAMALARI: BIST İMALAT SEKTÖRÜ ÖRNEĞİ
Authors: TEMİZ Hüseyin , DALKILIÇ Elçin , HACIHASANOĞLU Tansel
Published: January 2018

Bu çalışmanın amacı firmaların yönetim kurulu yapısı (bağımsız üye, denetim komitesi, kadın üye ve yönetim kurulu büyüklüğü) ve kâr yönetimi uygulamaları arasındaki ilişkinin incelenmesidir. Söz konusu ilişkinin incelenmesi amacıyla dört farklı kâr yönetimi tahmin modeli kullanılmış ve dört hipotez test edilmiştir. Çalışma kapsamında BIST İmalat Sektöründe faaliyet gösteren firmalara ait 2011 – 2016 yıllarını kapsayan veriler kullanılmıştır. Elde edilen sonuçlara göre; yönetim kurulu içindeki bağımsız üye oranının tahakkuk ve gelir manipülasyonu temelli kâr yönetimi uygulamaları ile ilişkili olduğu ve yönetim kurulundaki kadın üye oranının artmasının nakit akışı ve gelir manipülasyonu temelli kâr yönetimi uygulamalarını azalttığı görülmüştür. Yönetim kurulu büyüklüğünün artmasının da nakit akışı ve gelir manipülasyonu temelli kâr yönetimi uygulamalarını azalttığı tespit edilmiştir. Çalışma kapsamında elde edilen bulguların denetim komitesi üye oranının kâr yönetimi uygulamalarını azalttığı hipotezini desteklemediği sonucuna ulaşılmıştır.
KÜRESEL REKABET ENDEKSİ GÖSTERGELERİNİN KÜRESEL İNOVASYON ENDEKSİ ÜZERİNDEKİ ETKİSİ
Authors: AY TÜRKMEN Mevhibe , AYNAOĞLU Yeliz
Published: January 2018

Değişen rekabet ortamında inovasyon, ekonomilerin rekabet üstünlüğü sağlaması için önemli bir etmendir. Bir ekonomi inovasyona ne kadar önem veriyorsa diğer ekonomilerle rekabette o kadar gücü elinde tutuyor demektir. Rekabet ve inovasyon arasındaki bu etkileşime dayalı olarak bu çalışmada, Küresel Rekabet Endeksi (KRE) ile Küresel İnovasyon Endeksi (KİE) arasındaki ilişki incelenecektir. Bu bağlamda Küresel İnovasyon Endeksi sıralamasında 2009 yılında ilk 30’daki 29 ülkenin; Küresel Rekabet Endeksi parametrelerinin Küresel İnovasyon Endeksi üzerinde nasıl bir etkiye sahip olduğunu regresyon analizi ile tespit edilmeye çalışılmıştır. Çalışmada her iki endeksin 2009-2017 yılları arasındaki verileri kullanılmıştır. Çalışma sonucunda KİE ile KRE parametrelerinden yüksek eğitim ve öğretim, inovasyon ve emek piyasası etkinliği arasında yüksek pozitif bir ilişki olduğu tespit edilmiştir. En düşük etkinin makroekonomik çevre parametresi ile olduğu görülmüştür. KRE faktör grupları üzerine yapılan modelde ise inovasyon ve uzmanlaşma faktör grubu ile KİE arasında istatistiksel olarak anlamlı bir ilişki tespit edilmiştir.
MARKANIN BENLİĞİ İFADE ETMESİ VE SOSYAL GÖRÜNÜRLÜĞÜNÜN MARKA AŞKI İLE İLİŞKİSİ
Authors: UYAR Kumru , LEKESİZCAN Feyza Somtaş
Published: January 2018

Bu çalışmanın konusu çok sınırlı sayıda çalışmada ele alınan marka aşkıdır. Tüketicinin işletme ile kurmuş olduğu duygusal bağın uzun dönemde sürdürülmesi marka aşkı kavramını günümüzde hem tüketiciler hem de üreticiler açısından oldukça önemli hale getirmektedir. Tüketiciler tarafından sevilen bir marka rekabette çok büyük bir güç elde edebilmektedir.  Çalışmanın temel amacı, marka aşkı ile markanın benliği ifade etmesi ve sosyal görünürlüğü arasındaki ilişkileri belirlemektir. Çalışmanın amaçları doğrultusunda hazırlanan anket formu ile Kayseri il merkezinde yaşayan 459 tüketiciden toplanan veriler SPSS 22 paket programı ile analiz edilmiştir. Araştırmanın bulguları, markanın hem iç benliği hem de sosyal benliği ifade etmesi ile marka aşkı arasında iki boyut açısından da orta düzeyde ilişkiler olduğunu ortaya koymaktadır. Ayrıca marka aşkı ile markanın sosyal görünürlüğü arasında da orta düzeyde ilişki olduğu tespit edilmiştir.  Markanın sosyal görünürlüğü, önceki literatürde ele alınmamıştır. Bu çalışmanın, marka aşkı literatüründe markanın sosyal görünürlüğünü ele alan ilk çalışma olarak konunun daha çok anlaşılmasına katkı sağlaması beklenmektedir.
ÇALIŞAN BİREYLERİN YEŞİL ÜRÜN REKLAMLARINA YÖNELİK TUTUMLARINI ETKİLEYEN FAKTÖRLERİN DEMOGRAFİK ÖZELLİKLERİNE GÖRE FARKLILIKLARI
Authors: BENLİ Tahir , KARAOSMANOĞLU Kübra , TAŞ Özlem
Published: January 2018

Doğanın her tür ihtiyaca cevap verecek şekilde dikkatsizce tüketilmesi ekolojik dengenin bozulmasına ve çevresel kaynakların tükenme noktasına gelmesine neden olmuştur. Doğanın yapısının zarar görmesi sonucu oluşan çevresel sorunlar sadece ekolojik sistemi etkilemeyip, insan sağlığı için de büyük sorun olmaktadır. Yaşam koşullarını sürdürecek kaynakların ve yaşam alanlarının giderek azaldığının farkına varan tüketiciler de tüketim sürecinde daha hassas davranma eğilimindedirler. İşletmeler de bu durumda varlıklarını güçlendirmek amacıyla ve diğer işletmelerle yaşadıkları rekabetten sıyrılmak için,  ortaya koydukları ürün ve hizmetlerinin tanıtımında yeşil reklam uygulamalarına yönlenmişlerdir. Yapılan bu çalışma ile işletmelerin yeşil ürün reklamlarına yönelik çalışan bireylerin tüketici tutumlarını etkileyen faktörlerin belirlenmesi ve demografik özelliklere göre farklılıklarının incelenmesi amaçlanmıştır. Bu amaç doğrultusunda hazırlanan anket formu Kastamonu Merkez ilçede çalışan bireyler arasından kolayda örnekleme yöntemi ile seçilen 400 kişi üzerinde uygulanmış ve çalışan bireylerin işletmelerin yeşil ürün reklamlarına yönelik tutumlarını etkileyen faktörlerin cinsiyete, medeni duruma, yaşa, eğitime ve mesleğe göre anlamlı şekilde farklılaştığı belirlenmiştir
Tools Allowing Independent Visualization and Genetic Manipulation ofDrosophila melanogasterMacrophages and Surrounding Tissues
Authors: Gyoergy Attila , Roblek Marko , Ratheesh Aparna , Valoskova Katarina , Belyaeva Vera , Wachner Stephanie , Matsubayashi Yutaka , Sánchez-Sánchez Besaiz J , Stramer Brian , Siekhaus Daria E
Published: January 2018

Drosophila melanogaster plasmatocytes, the phagocytic cells among hemocytes, are essential for immune responses, but also play key roles from early development to death through their interactions with other cell types. They regulate homeostasis and signaling during development, stem cell proliferation, metabolism, cancer, wound responses, and aging, displaying intriguing molecular and functional conservation with vertebrate macrophages. Given the relative ease of genetics in Drosophila compared to vertebrates, tools permitting visualization and genetic manipulation of plasmatocytes and surrounding tissues independently at all stages would greatly aid a fuller understanding of these processes, but are lacking. Here, we describe a comprehensive set of transgenic lines that allow this. These include extremely brightly fluorescing mCherry-based lines that allow GAL4-independent visualization of plasmatocyte nuclei, the cytoplasm, or the actin cytoskeleton from embryonic stage 8 through adulthood in both live and fixed samples even as heterozygotes, greatly facilitating screening. These lines allow live visualization and tracking of embryonic plasmatocytes, as well as larval plasmatocytes residing at the body wall or flowing with the surrounding hemolymph. With confocal imaging, interactions of plasmatocytes and inner tissues can be seen in live or fixed embryos, larvae, and adults. They permit efficient GAL4-independent Fluorescence-Activated Cell Sorting (FACS) analysis/sorting of plasmatocytes throughout life. To facilitate genetic studies of reciprocal signaling, we have also made a plasmatocyte-expressing QF2 line that, in combination with extant GAL4 drivers, allows independent genetic manipulation of both plasmatocytes and surrounding tissues, and GAL80 lines that block GAL4 drivers from affecting plasmatocytes, all of which function from the early embryo to the adult.
Welcome to Asian Journal of Health Sciences
Authors: Mukkadan J.K. , Kumar G Sai sailesh
Published: January 2018

Asian Journal of health sciences in collaboration with Angamaly charter of APPI at LFMRC, is the official journal of Little Flower Medical Research Centre (LFMRC), Angamaly, Kerala, India. This is a multidisciplinary, peer reviewed, open access, half yearly journal which publishes a wide range of scientific works including original research papers, case reports, reviews, audits, editorials, book reviews and articles from medical students. The submitted articles in various fields of health sciences are fully peer- reviewed. These articles are only published after the referees careful consideration and opinion and other necessary corrections. The policy of the journal is to encourage the new generation of Healthcare Professionals to publish articles in time. Finally I'd like to express my gratitude to all who have worked hard to come up with the first issue of AJHS.
Study Of Dementia With Particular Reference To Mini Mental State Examination And Geriatric Depression Scale In Diabetic Patients
Authors: Rahmath Abdul Rahiman , Krishnaprabha Pattath Sadanandhan , Sana Varma , Suresh Kumar Pichakacheri , Sreekumaran Edakkot
Published: January 2018

To detect the effect of dementia related problems on a person's cognitive functions, especially memory and the occurrence of depression like symptoms by using Mini Mental State Examination (MMSE) and Geriatric Depression Scale (GDS). The subjects were divided into three, one as general group who are non- diabetic, second as control group who are diabetic and non- neuropathic and the third as test group, who are diabetic as well as neuropathic. The six parameters analyzed were age, gender, duration of diabetes, family history of diabetes, Body Mass Index (BMI) and food habits. The scores were then statistically analyzed using SPSS (Statistical Package for Social Sciences, 12.0.1). The results in the present study reveal that there is a decline in the cognitive performance in MMSE based on gender, but in the case of age and duration of diabetes, the test group subjects showed a poorer performance. A decline in MMSE score shows greater risk for cognitive impairment. Similarly GDS scores also support this result.Diabetic neuropathic patients poorly performed in MMSE and GDS when compared to non- neuropathic patients. Diabetes has a significant role in the deterioration of cognitive function. Females showed poor performance than males. As age and duration of diabetes progresses, the chance for memory loss and depression increases. Food habits have no significant role as per this study.
Does Rural to Urban Migration Improves Indian Women's Health Status and Knowledge of AIDS
Authors: Agrawal Sutapa , Agrawal Praween
Published: January 2018

The present paper explores the effect of patterns and duration of migration upon health and morbidity condition of women and knowledge and awareness of AIDS. Cross-sectional data from India's second National Family Health Survey (NFHS-2, 1998-99) is used for this study. Analysis is based on 73,558 women age 15-49 years who belonged to different streams of migration. Bivariate as well as multivariate techniques have been used for data analysis.Women migrating towards rural area are more underweight than migrating towards urban area whereas reverse for overweight. However, women migrating from rural to rural area were more anaemic than women migrating from rural to urban area. Significant differences were also found for morbidity conditions like Asthma, Tuberculosis, Jaundice, Malaria and some reproductive health problems according to streams of migration. Knowledge of AIDS also significantly differs according to the stream and duration of migration. We found stream of migration and duration of migration plays a key role in health, morbidity condition and knowledge of AIDS among women. Therefore, quality of health care in urban areas should be more widely disseminated in rural areas to improve the health status of women. Also the information-education-communication (IEC) programmes related to AIDS should be made more strengthened and effective through television, radio and also through the school teachers to reach the rural masses in India.
A study on effect of oral administration of cardamom on memory boosting and regaining in wistar albino rats
Authors: Setty Prabha V , Sailesh Kumar Sai , Neethu Neethu , J.K Mukkadan
Published: January 2018

This study provides further evidence for improvement of memory by oral consumption of cardamom. The present study was undertaken with an objective to study the effects of oral administration of cardamom on memory boosting and regaining. Here we investigate the influence of oral intake of cardamom on behavioral task performance by using T-maze and radial arm maze and physiological measures relative to a milk control group. We have observed significant memory boosting and memory regaining effects of cardamom when administered orally. This effect may be due to facilitation of acetylcholine activity by decreasing acetyl cholinesterase activity of cardamom. Hence we recommend further research in this area by investigating compound metabolism to optimize quantification of memory performance following cardamom consumption
Nem szteroid gyulladáscsökkentők peroralis és transdermalis alkalmazása regionális mozgásszervi fájdalmi szindrómákban
Authors: Hodinka László , Bálint Géza , Budai Erika , Géher Pál , Papp Renáta , Somogyi Péter , Szántó Sándor , Vereckei Edit
Published: January 2018

Abstract:

In this review the available evidences regarding the most frequently applied medication (peroral and transdermal non-steroidal anti-inflammatory agents) for the most frequent musculoskeletal complaints (regional pain syndromes) have been collected for the appropriate medical professionals who are most frequently faced with these conditions (general practitioners, rheumatologists, orthopedics, occupational and sports medicine experts). The special population at risk (with repeated and high energy overuse because of occupational or sport activities) and the pathology of their syndromes are identified. Mode of action, pharmacological properties of the non-steroidal anti-inflammatory drugs and the unwanted effects of their application especially in infants and elderly are highlighted. Recommendations of the general and specific pain management guidelines have been selected and listed in the review. Orv Hetil. 2017; 158(Suppl. 3): 3–30.
A magyar pszichiáter identitása. Egy tudományos felmérés tapasztalatai
Authors: Incze Adrienne , Kéri Szabolcs , Szekeres György
Published: January 2018

Abstract:

Introduction: A main determinant of professional identity is the integrity of the discipline. The complexity of psychiatry in biological, psychological and sociological aspects is a typical instance of the necessity for integration. Aim: Based on the bio-psycho-social dimensions and on their opinion about acceptance of psychiatry, we explored the professional identities of physicians working in Hungarian contemporary psychiatry. Method: Voluntary, anonymous responses were collected by using a 10-point evaluation scale on professional attitude, appreciation of psychiatry from lay society and other medical professions, and the importance of biology, psychology and sociology within psychiatry. Results: The 228 respondents showed a highly significant effect of basic sciences: biology was the most relevant followed by psychology and sociology. Specialists in psychiatry (n = 171) showed a more marked preference for biology than the trainees, while specialists in psychotherapy (n = 74) considered the psychological component significantly more important than other respondents. The public acceptance of psychiatry was low as compared with other medical professions. Conclusions: The consistency between self-image and profession shows that the multidimensionality of psychiatry is not primarily an individual challenge. The impact on identity shows the key importance of education. Improving the prestige of psychiatry requires keeping our professional identity up-to-date, communicating with physicians with different preferences, and cooperating with other medical professions. Orv Hetil. 2018; 159(2): 58–63.
Elsődleges genetikai vizsgálat Prader–Willi-szindróma igazolására
Authors: Ács Orsolya Dóra , Péterfia Bálint , Hollósi Péter , Haltrich Irén , Sallai Ágnes , Luczay Andrea , Buiting Karin , Horsthemke Bernhard , Török Dóra , Szabó András , Fekete György
Published: January 2018

Abstract:

Introduction: According to the international literature, DNA methylation analysis of the promoter region of SNRPN locus is the most efficient way to start genetic investigation in patients with suspected Prader–Willi syndrome. Aim: Our aim was to develop a simple, reliable first-tier diagnosis to confirm Prader–Willi syndrome, therefore to compare our self-designed simple, cost-efficient high-resolution melting analysis and the most commonly used methylation-specific multiplex ligation-dependent probe amplification to confirm Prader–Willi syndrome. Method: We studied 17 clinically suspected Prader–Willi syndrome children and their DNA samples. With self-designed primers, bisulfite-sensitive polymerase chain reaction, high-resolution melting analysis and, as a control, methylation-specific multiplex ligation-dependent probe amplification were performed. Results: Prader–Willi syndrome was genetically confirmed in 6 out of 17 clinically suspected Prader–Willi syndrome patients. The results of high-resolution melting analysis and methylation-specific multiplex ligation-dependent probe amplification were equivalent in each case. Conclusion: Using our self-designed primers and altered bisulfite-specific PCR conditions, high-resolution melting analysis appears to be a simple, fast, reliable and effective method for primarily proving or excluding clinically suspected Prade-Willi syndrome cases. Orv Hetil. 2018; 159(2): 64–69.
Tompa pancreastrauma diagnózisa és kezelése
Authors: Kollár Dániel , Molnár F. Tamás , Zsoldos Péter , Oláh Attila
Published: January 2018

Abstract:

The management of thoracic and abdominal organ injuries has very thorough and extensive literature, including evidence-based protocols. Pancreatic trauma stands as an exception. Blunt or penetrating trauma of the pancreas is rather rare (less than 2% of all trauma cases, approximately 3–12% of all abdominal trauma), leading to the lack of high-level evidences regarding its treatment. Damage of the pancreas parenchyma can cause substantial morbidity and mortality, therefore it is essential to separate cases where conservative treatment suffices from those that need surgical approach. This study aims to review the conclusions of relevant articles of the past decades concerning the management of both adult and childhood pancreatic trauma. Classifications and their reliability are revised. We enlist scaling systems that can help in making decision whether to operate or to treat conservatively, from physical examination to diagnostic measures and complications. To date, the treatment principles of pancreatic trauma are not based either on prospective or on randomised trials. The database search of studies retrieved only retrospective and/or small case cohorts, case reports and expert opinions (levels 4 and 5 of evidence). However, it is a generally accepted conviction that the damage of the main pancreatic duct determines if the pancreatic injury is of low or high grade. Available classifications are based on the same principle. Conservative treatment is feasible given that the patient is hemodinamically stable and the pancreatic duct is unimpaired. If duct lesion is discovered, adult cases are to be treated with minimally invasive (percutaneous or endoscopic) measures or surgically (including reconstruction, resection and drainage). The management of childhood injuries has controversial literature. Many arguments can be enumerated on the operative as also on the non-operative approach, this confusion is to be clarified in the future. The highest morbidity rates are derived from the late diagnosis of the pancreatic duct, while increased mortality is seen in the polytrauma patient groups. Levels 1–2 evidence-based recommendations are needed, but planning of strong trials is critically limited due to the small number of cases and the heterogeneity of the relevant patient groups. Orv Hetil. 2018; 159(2): 43–52.
Mellkasiaortastentgraft-beültetések Magyarországon 2012 és 2016 között
Authors: Fontanini Daniele Mariastefano , Fazekas Gábor , Vallus Gábor , Juhász György , Váradi Rita , Kövesi Zsolt , Kolossváry Márton , Szeberin Zoltán
Published: January 2018

Abstract:

Thoracic aortic endograft implantation has become a widespread procedure in recent years, yet no report is available about Hungarian outcomes. Examination of our results is crucial to define further treatment strategies. Analysis of perioperative data from Hungarian thoracic endograft implantations based on the experience of 5 years is presented. Our retrospective, multicentric study analysed voluntarily reported data from all Hungarian institutions where thoracic endograft implantations are performed. Information was collected from every procedure performed in 5 years. Between 2012 and 2016, 131 thoracic stent graft implantations were performed in Hungary (67.18% male, mean age 62.80 years). 25.19% of the procedures were acute. 13.74% of the patients were diabetic. Indications for the procedure were aneurysm (64.89%), dissection (17.56%), aortic trauma (6.87%) and other conditions (10.69%). 73.91% of the dissection cases were acute. 16.47% of repaired aneurysms were ruptured. Additional preoperative revascularization (debranching) was performed in 26.72% of the cases. Postoperative stroke occured in 4.58%, temporary hemodialysis was needed in 1.53%, bowel ischaemia was present in 2.29% and reoperation within 30 days was needed in 5.34% of all cases. Thirty-day mortality of the procedure was 9.92%, 5-year long-term mortality reached 16.03%. Endovascular repair of the thoracic aorta is an effective procedure and our national data comfirmed its advantages compared to open thoracic surgery. Further use of the procedure in Hungary depends on the centralised care in vascular surgery and financial matters. Multidisciplinary cooperation and proper logistics are needed to provide patients with optimal treatment. Orv Hetil. 2018; 159(2): 53–57.
Cubic InGaN Grown by MOCVD
Authors: Li J.B. , Yang Hui , Zheng L.X. , Xu D.P. , Wang Y.T.
Published: January 2018

We report on the growth of high-quality cubic phase InGaN on GaAs by MOCVD. The cubic InGaN layers are grown on cubic GaN buffer layers on GaAs (001) substrates. The surface morphology of the films are mirror-like. The cubic nature of the InGaN films is obtained by X-ray diffraction (XRD) measurements. The InGaN layers show strong photoluminescence (PL) at room temperature. Neither emission peak from wurtzite GaN nor yellow luminescence is observed in our films. The highest In content as determined by XRD is about 17% with an PL emission wavelength of 450 nm. The FWHM of the cubic InGaN PL peak are 153 meV and 216 meV for 427 nm and 450 nm emissions, respectively. It is found that the In compositions determined from XRD are not in agreement with those estimated from PL measurements. The reasons for this disagreement are discussed.
Extended Defects in GaN: a Theoretical Study
Authors: Elsner J. , Frauenheim Th. , Haugk M. , Gutierrez R. , Jones R. , Heggie M. I.
Published: January 2018

We present density–functional theory studies for a variety of surfaces and extended defects in GaN. According to previous theoretical studies1{100} type surfaces are electrically inactive. They play an important role in GaN since similar configurations occur at open–core screw dislocations and nanopipes as well as at the core of threading edge dislocations. Domain boundaries are found to consist of four–fold coordinated atoms and are also found to be electrically inactive. Thus, except for full–core screw dislocations which possess heavily strained bonds all investigated extended defects do not induce deep states into the band–gap. However, electrically active impurities in particular gallium vacancies and oxygen related defect complexes are found to be trapped at the stress field of the extended defects.
High Quality Hydrothermal ZnO Crystals
Authors: Suscavage M. , Harris M. , Bliss D. , Yip P. , Wang S.-Q. , Schwall D. , Bouthillette L. , Bailey J. , Callahan M. , Look D. C. , Reynolds D. C. , Jones R. L. , Litton C. W.
Published: January 2018

Zinc Oxide crystals have historically been grown in hydrothermal autoclaves with a basic mineralizer; however, doubts have been raised about the quality of such crystals because they have often exhibited large x-ray rocking curve widths and low photoluminescence (PL) yield with large linewidths. Several ZnO crystals were grown hydrothermally and sliced parallel to the c-plane. This resulted in opposite surfaces (the C+ and C−) exhibiting pronounced chemical and mechanical differences. Different surface treatments were investigated and compared by PL both at room temperature and liquid helium temperatures, and by double axis X-ray rocking curve measurements. The high quality of hydrothermally-grown ZnO is substantiated by the narrow rocking curve widths and sharp PL peaks obtained. A critical factor in obtaining these results was found to be surface preparation.
Physics-Based Intrinsic Model for AlGaN/GaN HEMTs
Authors: Wu Shangli , Webster Richard T. , Anwar A. F. M.
Published: January 2018

DC and intrinsic small signal parameters are reported for AlGaN/GaN high electron mobility transistors. The calculations are based upon a self-consistent solution of Schrödinger and Poisson’s equation to model the quantum well formed in GaN. Transport parameters are obtained from an ensemble Monte Carlo simulation.