bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitamin E and genistein generate a cytoprotective effect on polychlorinated biphenyl- induced oxidative stress in testicular Leydig cells
Authors: Aydin Yasemin , Orta Yılmaz Banu , Erkan Melike
Published: February 2024

Polychlorinated biphenyls (PCBs) are industrial substances which were widely used in industrial applications starting from the 1930s until the mid-1970s. Aroclor 1242 (A1242) is a commercial PCB mixture with 42% chlorine manufactured by the Monsanto Chemical Company in St. Louis, Missouri, USA. Previous studies suggested that PCBs have inhibitory effect on reproductive function, developmental abnormality, and impaired reproductive ability. PCBs may also affect the endocrine system by reducing the testosterone synthesis and the activity of steroidogenic enzymes in Leydig cells. This study was performed to investigate the specific effects of A1242 on the via-bility of Leydig cells, oxidative damage, and the profile of steroidogenic enzymes in an in vitro culture. The therapeutic effects of vitamin E (VitE) and genistein (Gen), as two antioxidants, in mitigating the damage produced by A1242 were also evaluated. TM3 Leydig cells were exposed to 10-8 and 10-6 M of A1242 and VitE (50µM) and Gen (10µM) as antioxidant for 24 h. After the exposure period, the Leydig cells were assessed to determine their viability using a cell viability assay. Measurements were performed for lipid peroxidation, reactive oxygen species (ROS), and steroidogenic enzymes. The results showed that cell viability was reduced after A1242 exposure, while lipid peroxidation and ROS increased. Steroidogenesis was interrupted in a concentration-dependent manner. Following A1242 exposure, administrations of VitE or Gen as an antioxidant reduced hazardous effects of A1242 on Leydig cells. Our results showed that exposure to A1242 may impair Leydig cell function and cause toxicity in Leydig cells and that VitE and Gen treatment exhibited therapeutic effects against this toxicity.
A parresia, o grito e as gretas
Authors: Estefogo Francisco
Published: February 2024

Este ensaio objetiva refletir sobre as perspectivas das linguagens decoloniais emancipatórias em prol da educação multi e intercultural (Walsh, 2009, 2019), de modo que a atividade educativa seja compreendida como uma tarefa política aletúrgica (Foucault, 1996, 2011). Em outros termos, um fazer educacional transgressor de protocolos, com vistas à ação cidadã participativa ética e crítica, como construtora de novas realidades e modos de ser, viver, desejar e pensar, portanto, questionadora do status quo e proporcionadora do cuidado de si e do outro (Foucault, 1996, 2011). Por meio da parresia (Foucault, 1996, 2011) e, a rigor, dos gritos e das gretas (Walsh, 2009, 2019), o foco desta proposta é debater as diversidades culturais, sejam elas linguísticas, políticas, sociais, étnicas, culturais, religiosas ou de gêneros, como capital pedagógico decolonial (Mignolo, 2017; Quijano, 2005; Walsh, 2009, 2019) epistêmico.  De forma igual, como característica e vocação imanente da humanidade para o avanço ontológico, epistemológico, ético-político, e, destarte, um possível manancial de linguagens decoloniais emancipatórias.
Machine learning and similar image-based techniques based on Nash game theory
Authors:   LMCSA, FSTM, Hassan II University of Casablanca, Salah F.-E. , Moussaid N. ,   LMCSA, FSTM, Hassan II University of Casablanca
Published: February 2024

The use of computer vision techniques to address the task of image retrieval is known as a Content-Based Image Retrieval (CBIR) system. It is a system designed to locate and retrieve the appropriate digital image from a large database by utilizing a query image. Over the last few years, machine learning algorithms have achieved impressive results in image retrieval tasks due to their ability to learn from large amounts of diverse data and improve their accuracy in image recognition and retrieval. Our team has developed a CBIR system that is reinforced by two machine learning algorithms and employs multiple clustering and low-level image feature extraction, such as color, shape, and texture, to formulate a Nash game. Consequently, we are faced with a multicriteria optimization problem. To solve this problem, we have formulated a three-player static Nash game, where each player utilizes a different strategy (color descriptor, Zernike descriptor, and SFTA descriptor) based on their objective function. The Nash equilibrium is defined as the membership classes of the query image.
Robust shape optimization using artificial neural networks based surrogate modeling for an aircraft wing
Authors:   LMSA Laboratory, Faculty of Science, Mohammed V University in Rabat, Moussaoui Z. , Karafi Y. ,   LMSA Laboratory, Faculty of Science, Mohammed V University in Rabat, Abou El Majd B. ,   LMSA Laboratory, Faculty of Science, Mohammed V University in Rabat; University of Lille, CNRS, CRIStAL, Inria Lille – Nord Europe
Published: February 2024

Aerodynamic shape optimization is a very active area of research that faces the challenges of highly demanding Computational Fluid Dynamics (CFD) problems, optimization with Partial Differential Equations (PDEs) as constraints, and the appropriate treatment of uncertainties. This includes the development of robust design methodologies that are computationally efficient while maintaining the desired level of accuracy in the optimization process. This paper addresses aerodynamic shape optimization problems involving uncertain operating conditions. After a review of possible approaches to account for uncertainties, an Artificial Neural Network (ANN) model is used to approximate the aerodynamic coefficients when the operating conditions vary. Robust optimization problem-solving approaches based on deterministic measurements are used, inspired by the work of Deb [Deb K., Gupta H. Introducing robustness in multi-objective optimization. KanGAL Report 2004–2016, Kanpur Genetic Algorithms Laboratory, Indian Institute of Technology, Kanpur, India (2004)]. The first procedure is a direct extension of a technique used for single-objective optimization. The second is a more practical approach allowing a user to define the desired degree of robustness in a problem. These approaches have been tested and validated in the case of the optimization of an aircraft wing profile in the transonic regime considering two uncertain variables: the Mach number and the angle of incidence.
Kırsal Kalkınma Aracı Olarak Defne Toplayıcılığının Durum Analizi
Authors: GÜNGÖR Ersin , ÇOBAN Mertcan
Published: February 2024

Odun Dışı Orman Ürünleri (ODOÜ), sağladığı gelir bakımından kırsal kalkınma için stratejik bir araçtır. Defne (Laurus nobilis L.), dünyada ekonomik değeri yüksek olan bir ODOÜ’dür. Dünya defne varlığının %90’ı Türkiye’de bulunmaktadır. Ülkemizde defne, önemli bir kırsal kalkınma aracı haline gelmiştir. Kırsalda defne toplayıcılığına yönelik ilgi her geçen gün artmaktadır. Son yıllarda iklim değişikliği ve sürdürülebilir olmayan düzensiz hasat, defne türünün devamlılığını sekteye uğratmaktadır. Etkili stratejiler geliştirilmediği takdirde defne, ülkemiz kırsal kalkınma açısından önemini kaybetme tehlikesiyle karşı karşıyadır. Çalışmada, sürdürülebilir defne toplayıcılığına yönelik stratejilerin geliştirilmesi amaçlanmıştır. Çalışma, Türkiye’de defnenin en çok üretildiği il olan Bartın’da gerçekleştirilmiştir. Hedef kitle, kırsalda yaşayan ve defne toplayıcılığı yapan 18-65 yaş arası orman köylüleridir. Çalışmada 60 defne toplayıcısına anket uygulanmıştır. Anketin birinci bölümünde, katılımcıların sosyo-demografik özelliklerini belirleyen sorular, ikinci bölümünde ise sürdürülebilir defne toplayıcılığında durum analizine yönelik sorular yer almıştır. Analiz aşamasında A’WOT (AHP+SWOT) Tekniği kullanılmıştır. Araştırma bulgularına göre, defne toplayıcılığı yapanların önemli bir kısmı (%71’i) ilköğretim mezunudur. %12’si geçimini yalnızca defne hasadından sağlamaktadır. %47’si defne hasadını, tarım ve hayvancıkla birlikte yürütmektedir. A’WOT sonuçlarına göre; defne toplayıcılığında güçlü-zayıf yönler sırasıyla bölgede nitelikli defne işleme tesislerinin varlığı (%31) ve defne toplayıcılarının bilgi düzeylerinde yetersizlik (%23) şeklindedir. Fırsatlar-tehditler tarafında ise sırasıyla yörede verimli defne sahalarının varlığı (%26) ve koruma-kullanım dengesi içinde yürütülmeyen defne toplayıcılık faaliyetleri (%20) gelmektedir. Bulgulara göre defne toplayıcılığında temel strateji; defne hasadına yönelik etkin planlama, defne sahalarını genişletme ve niteliğini arttırma, yetiştirme-hasat konusunda bilinç oluşturma, bilgilendirme ve defne işlemede katma değeri yüksek üretim şeklinde sıralanabilir.
Examining Communication Challenges During Internationalization Processes in Uzbek Organizations
Authors: Ibadullaeva Gulnoza
Published: February 2024

The overarching purpose of this study is to provide theoretical and practical insights to potential investors considering investments in various business sectors in Uzbekistan, an emerging economy that has been sparsely explored from a business and management perspective. Applying a case study approach, this study presents empirical evidence from semi-structured interviews with managers having considerable experience in internationalization processes in four organizations in Uzbekistan. The study focuses on processes of organizational communication, leadership, and culture, particularly in organizations aiming to internationalize their operations. The findings offer practical suggestions for organizations considering internationalization as a business strategy. To achieve optimal performance in internationalization, organizations must establish an effective communication environment and understand the importance of leadership styles and the cultural facets of the organization. Furthermore, to enhance their internationalization process, organizations in developing economies, such as Uzbekistan, could utilize the techniques employed by international companies as a platform for training.
To the concept of an agricultural land plot
Authors: Yankovskyi V. A.
Published: February 2024

The article is devoted to the study of the concept of an agricultural plot of land. It was established that the specific current legislation has many references to such a category as agricultural land, but such legislation does not contain a definition of the concept of agricultural land.

Issues related to the concept of an agricultural plot of land, the procedure for its use, restoration, establishment of responsibility for violations in the field of land relations are constantly becoming the subject of both scientific and practical interest.

Taking into account the careful study of certain issues of the use of agricultural land plots, after the introduction of the land circulation mechanism and the changes in this mechanism that will take place in the near future (01.01.2024), the recently introduced changes in the relevant legislation regarding the possibility of withdrawing from the permanent use of state agricultural land plots property by decision of the Cabinet of Ministers of Ukraine without the consent of state enterprises, institutions, organizations and without the consent of the bodies (organizations) to which they belong, and transfer for permanent use to other state enterprises (July 27, 2023), there is a need to carry out study of the concept of agricultural land plot.

It has been established that the concepts of agricultural plot and agricultural land are related as part and whole, and therefore it is impossible to equate agricultural plot with agricultural land. A land plot is considered formed from the moment it is assigned a cadastral number, and the formation of a land plot involves determining its area, boundaries and entering information about it into the State Land Cadastre. The legislation defines the list of persons who can acquire the right of ownership and use of agricultural land plots. The legislation has changed the regime for the use of agricultural land plots by state-owned entities. The author’s definition of the concept of agricultural land plot is given.
Doctrine of locus standi: occurrence and evolution in administrative law
Authors: Pidluzhnyi V. M.
Published: February 2024

This article is dedicated to the issues of the history of the emergence and evolution of the locus standi doctrine (locus standi in judicio). The occurrence of the term “locus standi,” as well as its manifestations in Roman law, the Middle Ages, the Renaissance, and the 20th century, allows for a better understanding of the locus standi doctrine and possible avenues for its development. In administrative law of the United States, Canada, France, Italy, South Africa, and other countries, the locus standi doctrine holds a prominent place. Ukranian legal system operates with the right to access to the court, the right to appeal to an administrative court, the right to judicial protection, and the right to seek redress, which can have different meanings depending on their understanding in substantive or procedural aspects, taking into account their possible understanding in sensu stricto or sensu lato. In the aspect of determining the right to appeal to an administrative court, the presence of administrative procedural legal subjectivity in a person is crucial in national legal system. Any person with administrative procedural legal subjectivity can be a plaintiff in an administrative case, but not every plaintiff is a proper plaintiff in an administrative case. The right to protection belongs to the proper plaintiff, who has claims in a particular administrative legal dispute. The presence of the right to protection, and in the laws of the United States, Canada, France, Italy, and other countries – the presence of locus standi (locus standi in judicio) in a person, precedes the determination of the possibility of granting the claims of such a person. The evolution of the locus standi doctrine in this article is examined from the right of an individual to appear before popular assemblies in ancient Rome to the right of an individual to appear before the court and act as a plaintiff in a case in modern times. This article attempts to explore the historical aspect of the formation of the locus standi doctrine, as well as its potential application as a basis for further clarification of the substantive legal nature of a proper plaintiff.
Law enforcement of electronic government in the context of public-private partnership in the state security and defense sector
Authors: Zaikina H.M.
Published: February 2024

The article is devoted to the study of the law enforcement of electronic governance in the context of public-private partnership in the security and defense sector of the state. It was concluded that the application of electronic governance will be associated with general features of the use of digital technologies in the activities of public administration and special features mediated by public-private partnership in the security and defense sector of the state. It is noted that electronic governance is a concept of regulating social relations based on the use of digital technologies.

It has been established that the key characteristic of e-governance is digitization management with an emphasis on the needs of the citizen. Attention is focused on the fact that the specifics of the law enforcement of e-governance of public-private partnership in the security and defense sector of the state is mediated by the possibility of using digital technologies as regulators of social relations related to ensuring the proper state of security of the state and its national interests.

It was determined that the application of e-governance measures is an integral component of the national security of the state as a whole and the application of public-private partnership tools.

It was established that the following should implement their activities based on the principles of electronic governance: 1) bodies authorized to regulate activities related to public-private partnership as a whole; 2) bodies acting as a party to public-private partnership in the security and defense sector of the state.

The thesis that the degree of application of electronic governance tools in the public-private partnership in the security and defense sector will vary depending on the status of the entity that will act as a party to contractual relations from the state side is substantiated.

It is concluded that finding a balance between the use of digital tools that allow to simplify public access to the activities of public institutions during the implementation of public-private partnerships with the obligation not to disclose activities in this context will always lean towards the functional purpose of protecting the state over ideas digital transformation.
Is the GBIF appropriate for use as input in models of predicting species distributions? Study from the Czech Republic
Authors:   Global Change Research Institute, Štípková Zuzana , Tsiftsis Spyros ,   International Hellenic University, Kindlmann Pavel ,   Global Change Research Institute,   Charles University
Published: February 2024

Questions concerning species diversity have attracted ecologists and biogeographers for over a century, mainly because the diversity of life on Earth is in rapid decline, which is expected to continue in the future. One of the most important current database on species distribution data is the Global Biodiversity Information Facility (GBIF), which contains more than 2 billion occurrences for all organisms, and this number is continuously increasing with the addition of new data and by combining with other applications. Such data also exist in several national databases, most of which are unfortunately often not freely available and not included in GBIF. We suspected that the national databases, mostly professionally maintained by governmental organisations, may be more comprehensive than GBIF, which is not centrally organised and therefore the national databases may give more accurate predictions than GBIF. To test our assumptions, we have compared: (i) the amount of data included in the Czech database called Nálezová databáze ochrany přírody (NDOP, Discovery database of nature protection) with the amount of data in GBIF after its restriction to the Czech Republic, and (ii) the overlap of the predictions of species distributions for the Czech Republic, based on these two databases. We have used the family Orchidaceae as a model group. We found that: (i) there is a significantly larger number of records per studied region (Czech Republic) in NDOP, compared with GBIF, and (ii) the predictions of Maxent based on orchid records in NDOP are overlapping to a great degree with the predictions based on data based on orchid records in GBIF. Bearing in mind these results, we suggest that if only one database is available for the region studied, we must use this one. If more databases are available for the region studied, we should use the database containing most locations (usually some of the local ones, like NDOP), because using more locations implies larger significance of predictions of species distributions.
Resiliencia y oportunidades para cineastas en Panamá
Authors: Domínguez Carlos , Berbey Alvarez Aranzazu
Published: February 2024

En el siguiente estudio se analizó la resiliencia y las oportunidades para los cineastas panameños. Esta investigación tiene como propósito explorar la historia del cine panameño y demostrar que debemos seguir apoyando este rubro para que crezca nacionalmente e internacionalmente. Para obtener resultados se realizó un cuestionario mixto y una entrevista a profundidad a nueve productores del Concurso Fondo Cine 2021 en la categoría de Largometraje de Ficción o animación. Este estudio es uno de los primeros en explorar acerca de las oportunidades que existen para los cineastas de nuestro país. Se indagó con la finalidad de conocer el por qué el cine panameño no es valorado por la propia población. Los resultados arrojan que existen oportunidades, pero es un rubro lleno de obstáculos, principalmente porque no existe una cultura en los panameños que los haga sentirse atraídos por el cine local, ya que, no es promocionado debido a los pocos recursos que reciben para este fin. Si bien, es cierto el gobierno panameño, específicamente MiCultura brinda apoyo económico a los cineastas para producir, los fondos destinados a promoción y mercadeo de los proyectos de cine son escasos o nulos a comparación del cine importado que llega a Panamá. Mencionado lo anterior, se necesita valorar y crear una cultura de cine que debe ser construida desde las escuelas, para lograr aumentar el consumo de cine local, de tal forma, que los escritores, productores y directores se sientan respaldados y las oportunidades de crecer vayan en aumento
Analysis of Students' Ability to Work on PISA Questions in Personal Context for Students of Grade IX SMPN
Authors: Rauf Nurisnaeni , Nur Fitriani , Putra Rafli Permana , Munawarah  , Thalhah Sitti Zuhaerah
Published: February 2024

PISA (Programme for International Student Assesment) is an international standard study conducted by OECD who assesing the literacy skills of 15-year-olds’ students which is followed by several participating countries,including Indonesia. The research aim to describe the problem solving ability of junior high school students in solving PISA’s mathematic problems personal context. The methods of data collction used were observation, interviews and documentations. The validity of the data uses technical triangulation. Data analysis techniques through three processes those are data reduction, data presentation and draw the conclution. According to analysis results, mathematical ability of students in solving PISA’s mathematic problem personal context st level 1 is very good, at level 2 dan level 3 is good, level 4 and level 5 is still a lack and at level 6 is the worst. The results of the research can be explained that mathematical ability of students in solving PISA’s mathematic problem personal context for level 1-3 is good and for level 4-6 still a lack.
STUDI PENDAHULUAN INTEGRASI KEISLAMAN PADA KOMPETENSI KESEHATAN MASYARAKAT
Authors: Susanti Nofi , Indriani Fatma
Published: February 2024

Di Indonesia sendiri telah memiliki berbagai macam jenis universitas yang terikat dengan agama salah satunya universitas islam negeri maupun swasta untuk meningkatkan integritas keagamaan pada setiap mahasiswanya (Umam 2018). Integrasi islam serta ilmu pengetahuan diupayakan untuk tetap sejajar dan berada diposisi yang sama dalam mendapatkan ajaran serta pengetahuannya. Pentingnya integrasi keislaman dalam kesehatan menjadikan alasan kuat peneliti untuk membuktikan sejauh mana pemahaman mahasiswa Universitas Islam Negeri Sumatera Utara dalam hal integrasi dan kesehatan. Tujuan : penelitian ini dilakukan untuk mengetahui sejauh mana integrasi keislaman pada kompetisi dibidang kesehatan masyarakat. Metode : desain penelitian ini adalah  kuantitatif deskriptif yang melibatkan mahasiswa Universitas Islam Negeri Sumatera Utara sebanyak 35 mahasiswa yang berada di semester VII (Tujuh). Sampel diambil secara random yang berlangsung selama kurang lebih 1 bulan (September-oktober). Hasil : mahasiswa FKM UINSU sadar bahwa keterampilan dalam penilaian keagamaan itu diperlukan dan juga Mahasiswa FKM UINSU telah memiliki kesadaran dalam analisis data dan keterampilan penilaian, Serta terkait pengembangan kebijakan dan keterampilan perencanaan program. pada variabel terakhir mahasiwa memiliki kesadaran terkait keterampilan kepemimpinan dan berfikir sistem, hal ini membuktikan bahwa sebagai mahasiswa harus memiliki keterampilan dalam memimpin dan mampu menyelesaikan masalah secara luas dan dinamis agar dapat mencapai tujuan yang diinginkan.
EKSISTENSI GURU PROFESIONAL DALAM MENGAKOMODASI SEKOLAH
Authors: Asnita  , Rosdiana
Published: February 2024

The subject matter of this research is about how the existence of professional teachers in accommodating schools at SDIT Azzahrah Gowa, Samata Village, Somba Opu District, Gowa Regency. This research aims to 1) Knowing the performance of professional teachers at SDIT Azzahrah Gowa, 2) Describe professional teachers accommodating schools in SDIT Azzahrah Gowa, and 3) Find the principal's policy in forming professional teachers in SDIT Azzahrah Gowa.

This type of research is a descriptive qualitative research that is contained in participant observation which produces data and information in the form of words or sentences that come from the object of observation, using a pedagogical and sociological approach that explains descriptively and has primary data sources and secondary data. Data collection methods are observation and interview methods. The data processing and analysis techniques use data reduction, data presentation, and data verification and use triangulation techniques as a submission of data validity both technique, time and source triangulation.

The results of the interviews showed that 1) The existence of professional teachers in schools is very helpful in improving the quality of education, because the principal conducts training related to professional teachers in schools and teachers show complete administration in learning, 2) The application of professional teachers carried out by teachers in schools is by fulfilling the tools of teaching needs, attendance, making academic calendars, working meetings with other teachers, and proven by attending trainings to improve professional teachers in accommodating schools, 3) Reporting the existence of professional teachers in accommodating schools is evidenced by the improved performance of teachers in making lesson plans, timely attendance to school, good information systems, teacher leadership shows good examples, and conducts evaluations in a timely manner.

       The implication of the research is that teachers should be professional in carrying out their duties as educators in order to be able to make a good contribution in accommodating schools and it is hoped that this research can be an input and reference for further research
Nasal cycle
Authors: Kurzyński Wojciech , Krzywdzińska Sandra , Jurkiewicz Dariusz
Published: February 2024

The nasal cycle is a physiological phenomenon that may cause a periodic change in the patency of the nasal cavities through changes in congestion and constriction of the nasal mucosa especially in the inferior nasal turbinates. This phenomenon was first described by the German physician Richard Kayser in 1895. The nasal cycle is regulated by the hypothalamus via the sympathetic nervous system. Air flow through the nasal cavities is influenced by different factors such as hyperventilation, changes in body position, air temperature, nasal diseases, infection, allergy and vasomotor rhinitis, as well as medications like acetylsalicylic acid and sympathomimetics.
Nettle pollen - an important taxon of the summer pollen flora of Polish urban areas in the 2023 season
Authors: Majkowska-Wojciechowska Barbara , Balwierz Zofia , Piotrowska-Weryszko Krystyna , Górecki Artur , Rapiejko Anna , Kopacz-Bednarska Anna , Puc Małgorzata , Siergiejko Grzegorz , Malkiewicz Małgorzata , Chłopek Kazimiera , Lipiec Agnieszka
Published: February 2024

New significant clinical studies suggest the enormous preventive and therapeutic capabilities of Urtica dioica L. Despite being already known as multi-purpose plant, it is still underestimated and relatively poorly researched in regards to its allergenic potential. The aim of the study was to compare nettle pollen season in 2023 in ten cities located in different regions of Poland: Bialystok, Kraków, Kielce, Lublin, Olsztyn, Piotrków Trybunalski, Szczecin, Warszawa, Wrocław and Łódź. Nettle pollen grains were collected using Burkard or Lanzoni Hirst-type volumetric samplers. The 95% method was used to determine the duration of the pollen seasons. The nettle pollen season in 2023 began in June. The earliest onset of the pollen season was recorded in Kielce (June 15th), in Wrocław (June 16th) and Warszawa (June 17th). In most of the monitored cites maximum daily pollen concentrations were registered in the middle of September. Mean seasonal pollen index (SPI) reached the value of 8579. The highest total values (SPI) were in Lublin (14,387) in Kielce (13,424) and in Wrocław (12,304). The lowest total values level (SPI) was in Białystok (3434) and in Łódź (4935). But in Łódź in October 2023, thanks to favourable weather, many Urtica dioica L. plants bloomed again. Unfortunately, aerobiological research was no longer carried out at that time.
Charakterystyka i zastosowanie kliniczne dydrogesteronu – Stanowisko Grupy Ekspertów
Authors: Kwiatkowski Sebastian , Sieroszewski Piotr , Kalinka Jarosław , Paszkowski Tomasz , Kuczyński Waldemar , Jakimiuk Artur , Skrzypulec-Plinta Violetta , Wender-Ożegowska Ewa , Pawelczyk Leszek , Huras Hubert
Published: February 2024

Dydrogesteron został wprowadzony na rynek w 1961 r. i obecnie jest dostępny w ponad 100 krajach na całym świecie. Charakteryzuje się on dobrą biodostępnością i stabilnością metaboliczną, a także brakiem właściwości estrogenowych, androgenowych oraz mineralokortykoidowych i dobrym profilem bezpieczeństwa, dzięki czemu w wielu przypadkach klinicznych stanowi dobrą alternatywę dla innych progestagenów. Znajduje on zastosowanie w licznych wskazaniach ginekologiczno-położniczych, w tym w zaburzeniach wpływających na miesiączkę i ciążę, oraz w hormonalnej terapii menopauzalnej.
W niniejszym dokumencie przedstawiono stanowisko Grupy Ekspertów na temat możliwości stosowania dydrogesteronu w praktyce klinicznej. Przeprowadzono narracyjny przegląd bazy literaturowej, skupiając się na kwestii skuteczności i bezpieczeństwa dydrogesteronu stosowanego w: nieprawidłowych krwawieniach z macicy, bolesnym miesiączkowaniu, zespole napięcia przedmiesiączkowego, wtórnym braku miesiączki, leczeniu poronienia zagrażającego i nawracającego, niepłodności związanej z niewydolnością ciałka żółtego, endometriozie oraz w hormonalnej terapii menopauzalnej.
Zidentyfikowane dowody naukowe potwierdzają, że stosowanie dydrogesteronu w wielu sytuacjach klinicznych może być korzystne, a profil bezpieczeństwa leku jest bardzo dobry. Szerokie wykorzystanie dydrogesteronu w praktyce ginekologiczno-położniczej niewątpliwie jest zasadne, choć niezbędne są dalsze badania randomizowane, które bezsprzecznie potwierdzą skuteczność leku we wszystkich wskazaniach.
Influence of yeast size on the kinetics of cell disruption in an ultrasonic homogenizer
Authors: Kacprowicz Anna , Solecki Marek
Published: February 2024

The results of studies on the disintegration kinetics of the yeast Saccharomyces cerevisiae are presented. The process was carried out in a 500 W ultrasonic homogenizer equipped with a spherical working chamber with a volume of 100 cm 3. The concentration of the suspension of microorganisms was 0.05 g d.m./cm 3. The continuous phase was water solution containing 0.15 M NaCl and 4 mM K 2HPO 4. The kinetics of cell disruption were studied by the direct method. The theory of random transformation of dispersed matter was used to analyze the process. There was significant variation in the size of yeast cells. The range of changes in the values of parameters describing the size of microorganisms was divided into size classes. The kinetics of cell disruption in individual classes was described by a first-order linear differential equation. During the implosion of cavitation bubbles, the transformation volume of individual microorganisms is generated. It has been shown that as the volume of cells in subsequent size classes increases, their transformation volumes do not increase significantly. The safe volume for cells remains unchanged. As the size of the microorganisms increased, there was no increase in the constant rate of cell disruption.
A Yaw tracking algorithm for head movement from inertial sensors data
Authors: Borowska-Terka Anna , Strumiłło Paweł
Published: February 2024

Monitoring head movements is important in many aspects of life from medicine and rehabilitation to sports, and VR entertainment. In this study, we used recordings from two sensors, i.e. an accelerometer and a gyroscope, to calculate the angles of movement of the gesturing person’s head. For the yaw motion, we proposed an original algorithm using only these two inertial sensors and the detected motion type obtained from a pre-trained SVM classifier. The combination of the gyroscope data and the detected motion type allowed us to calculate the yaw angle without the need for other sensors, such as a magnetometer or a video camera. To verify the accuracy of our algorithm, we used a robotic arm that simulated head gestures where the angle values were read out from the robot kinematics. The calculated yaw angles differed from the robot’s readings with a mean absolute error of approx. 1 degree and the rate of differences between these values exceeding 5 degrees was significantly below 1 percent except for one outlier at 1.12%. This level of accuracy is sufficient for many applications, such as VR systems, human-system interfaces, or rehabilitation.
No evidence of the long-term in vitro toxicity of Aeroxide P25 TiO2 nanoparticles in three mammalian cell lines despite the initial reduction of cellular mitochondrial activity
Authors: Męczyńska-Wielgosz Sylwia , Bartłomiejczyk Teresa , Grądzka Iwona , Sommer Sylwester , Węgierek-Ciuk Aneta , Lankoff Anna , Sikorska Katarzyna , Wojewódzka Maria , Dobrzyńska Małgorzata , Kruszewski Marcin
Published: February 2024

We studied the effects of Aeroxide P25 titanium dioxide nanoparticles (TiO2 NPs) with a diameter of 21 nm on induction of DNA damage and long-term survival of three human cell lines: hepatocellular liver carcinoma HepG2, colorectal adenocarcinoma HT29 and lung carcinoma A549. The endpoints examined were DNA breakage estimated by the comet assay and oxidative base damage recognized by formamide-pyrimidine glycosylase (FPG) estimated with the FPG+ comet assay, frequencies of histone γH2AX foci and micronuclei, apoptosis, cell metabolic activity measured by mitochondrial activity (MTT) assay and long-term survival measured by colony-forming ability. Each cell line had a different pattern of DNA breakage and base damage vs. nanoparticle (NP) concentration and treatment time. There was no increase in the frequencies of histone γH2AX foci and micronuclei as compared to those in the untreated cells. In parallel with these results, no induction of apoptosis has been found in none of the cell lines tested. The reported experiments provided no evidence of the long-term in vitro toxicity of Aeroxide P25 TiO2 NPs, despite a slight decrease in mitochondrial activity and cell survival during the first 72 h.
The Canadian Foundation for Refugees
Authors: K.H.
Published: February 2024

Throughout the past spring many Canadians participated in local consultations held under the auspices of the Canadian Foundation for Refugees regarding the need for a national grass-roots organization on behalf of refugees. The Board of Directors of the Foundation has already decided to act on several of the 68 specific recommendations in the draft report
Pengetahuan dan Keinginan Pasien pada Sarana Pelayanan Kesehatan Gigi di Kecamatan Padang Utara Melakukan Vaksinasi COVID-19
Authors: Aziza Safira , Susi Susi , Nismal Harfindo
Published: February 2024

Background: Vaccination is an action to raise immunity actively by injecting an antigen substance to trigger the formation of antibodies to be immune from the disease or only experience mild symptoms. According to data from the Padang City Health Office, the North Padang sub-district is included in 5 sub-districts with low vaccination coverage. Objective: This study aims to determine the relationship between knowledge and the intention of dental clinic patients to carry out COVID-19 vaccination in the sub-district area of Padang Utara. Methods: This research is an analytical study using a Cross-Sectional design study approach with chii-square test. The sample in this study was 107 respondents using purposive sampling techniqueobtained from research questionnaires filled out by respondents. Data analysis using univariate and bivariate analysis processed by using SPSS.Results: 58.9% of respondents have good knowledge about vaccinating, and 66.4% are willing to vaccinate. 23.8% of respondents who had good knowledge but had a low intention to carry out COVID-19 vaccination, and as many 76.2% of respondents who had good knowledge with a high intention to carry out COVID-19 vaccination and obtained significant results with a p-value = 0.005 (<0.05)..Conclusion: There is a correlation between dental clinic patients’ knowledge of dental health service facilities in the sub-district area of Padang Utara with the intent to conduct COVID-19.
Quasi-Global Sensitivity Analysis of Supersonic Computational Fluid Dynamics Simulations
Authors: Powell Walker H. , Lee Michael W.
Published: February 2024

Determining the sensitivity of model outputs to input parameters is an important precursor to developing informative parameter studies, building surrogate models, and performing rigorous uncertainty quantification. Determining parameter sensitivities over a range of parameter values, termed global sensitivity analysis, requires many model evaluations sampled over the parameter space, which is intractable for many large-scale computational fluid dynamics (CFD) applications. For moderate parameter dimensions, we propose the use of Morris screening, a one-at-a-time quasi-global method for estimating parameter sensitivities over a range of parameter values for CFD simulations. The Morris method is implemented within a CFD framework that utilizes adaptive grid refinement, thereby enabling its application to state-of-the-art production-level problems. The method is shown to be viable for a model problem of supersonic flow over an axisymmetric capsule geometry with both physical and nonphysical (i.e., simulation-informing) input parameters. It is shown that Morris screening identifies relative parameter sensitivities consistent with those of more costly experimental and computational studies that were previously performed on this geometry.
Effect of knee pain on muscles imbalance and physical limitation in individuals with bilateral knee osteoarthritis: A comparative cross-sectional study
Authors: Khan Shabana , Waseem Huma , Ahmad Uzair
Published: February 2024

Objectives:

When osteoarthritis (OA) affects the knee, it causes muscle imbalance and physical limitations. This study aimed to determine the impact of knee pain on quadriceps strength, hamstring length, and physical limitations in individuals with bilateral knee OA.

Methods:

A cross-sectional study at Khyber Teaching Hospital and Northwest General Hospital, Peshawar, included individuals aged 50–65, who met the American College of Rheumatology criteria. Subjects diagnosed with bilateral knee OA (grade II or greater on the Kellgren–Lawrence grading scale) and experiencing pain in both knees (numeric pain rating scale [NPRS] score ≥ 1) were selected through purposive sampling (n = 70). Data collection involved the NPRS, modified belt stabilizer hand-held dynamometer, active knee extension test, and Western Ontario and McMaster Universities Arthritis Index (WOMAC) Urdu version questionnaire. Measurements from both knees assessed quadriceps muscle strength, hamstring length, and physical limitations.

Results:

The median interquartile range (IQR) of quadricep strength for the more painful knee was 0.53 (0.36) Nm/kg and 1.35 (0.34) Nm/kg for the less painful knee showing a significant difference in quadriceps strength (P < 0.01). In terms of hamstring length, the more painful knee had a median (IQR) of 29.0 (2.0) degrees whereas the less painful knee recorded 11.0 (6.0) degrees indicating a significant difference (P < 0.01). Likewise, there was a significant difference in WOMAC scores between the less painful and more painful knees (P < 0.01).

Conclusion:

This study found that individuals experiencing more knee pain demonstrated decreased quadriceps muscle strength and increased hamstring muscle tightness. In addition, those with more painful knees exhibited greater physical limitations in bilateral knee OA.
Triple-Dearomative Photocycloaddition – A Strategy to Construct Novel Caged Molecular Frameworks
Authors: ji kaijie , Parthiban Jayachandran , Jockusch Steffen , Sivaguru Jayaraman , porco john
Published: February 2024

An unprecedented, caged 2H-benzo-dioxo-pentacycloundecane (BDPC) framework was serendipitously obtained in a single transformation via a triple-dearomative photocycloaddition of chromone esters with furans. This caged structure was generated during the course of an effort to access a tricyclic, oxygen-bridged intermediate enroute to the dihydroxanthone natural product nidulalin A. Reaction scope and limitations were thoroughly investigated, revealing the ability to access a multitude of synthetically challenging caged scaffolds in a two-step sequence. Photophysical studies provided key mechanistic insights on the process for formation of the novel caged scaffold.
Azophosphines: Synthesis, Structure and Coordination Chemistry
Authors: Jordan Emma , Calder Ethan , Adcock Holly , Male Louise , Nieger Martin , Slootweg Chris , Jupp Andrew
Published: February 2024

The conceptual replacement of nitrogen with phosphorus in common organic functional groups unlocks new properties and reactivity. The phosphorus-containing analogues of triazenes are underexplored but offer great potential as flexible and small bite-angle ligands. This manuscript explores the synthesis and characterisation of a family of air-stable azophosphine-borane complexes, and their subsequent deprotection to the free azophosphines. These compounds are structurally characterised, both experimentally and computationally, and highlight the availability of the phosphorus lone pair for coordination. This is confirmed by demonstrating that neutral azophosphines can act as ligands in Ru complexes, and can coordinate as monodentate or bidentate ligands in a controlled manner, in contrast to their nitrogen analogues.
Transition Metal-Free Catalytic C−H Zincation and C−H Alumination
Authors: Bisai Milan , Losiewicz Justyna , Sotorrios Lia , Nichol Gary , Dominey Andrew , Cowley Michael , Thomas Stephen , Macgregor Stuart , Ingleson Michael
Published: February 2024

C−H metalation is the most efficient method to prepare aryl–zinc and –aluminum complexes that are highly useful nucleophiles. Virtually all C–H metalation routes to form Al or Zn organometallic reagents require stoichiometric, strong Brønsted bases with no base-catalyzed reactions reported, to our knowledge. Herein we present a catalytic C–H metalation process to form aryl-zinc and aryl-aluminum complexes that uses only simple amine bases (e.g., Et3N) in sub-stoichiometric quantity (10 mol%). Key to this approach is coupling an endergonic C–H metalation step using a [(-diketiminate)MNR3]+ (M = Zn or Al–Me) electrophile with a sufficiently exergonic dehydrocoupling step between the acidic ammonium salt by-product of C–H metalation ([(R3N)H]+) and a Zn–H or Al–Me containing complex. This step, forming H2/MeH, makes the overall cycle exergonic while also generating more of the key cationic metal electrophile. Mechanistic studies supported by DFT calculations revealed metal-specific dehydrocoupling pathways, with the divergent reactivity shown to be due to the different metal valency (which impacts the accessibility of amine-free cationic complexes) and steric environment. Notably, dehydrocoupling in the zinc system proceeds through a ligand-mediated pathway involving protonation of the -diketiminate C position. In this step the magnitude of the key barrier is dependent on the steric bulk of the spectator ligand, with bulkier ligands actually affording lower barriers. This catalytic approach to arene C−H metalation has the potential to be applicable to other main group metals and ligands, thus will facilitate the synthesis of these important organometallic compounds.
For Catching-by-Polymerization Oligo Purification: Scalable Synthesis of the Precursors to the Polymerizable Tagging Phosphoramidites
Authors: Yin Yipeng , Chillar Komal , Apostle Alexander , Halami Bhaskar , Eriyagama Adikari M. D. N. , Tanasova Marina , Fang Shiyue
Published: February 2024

The catching-by-polymerization (CBP) oligodeoxynucleotide (oligo or ODN) purification method has been demonstrated suitable for large-scale, parallel, and long oligo purification. The authenticity of the oligos has been verified via DNA sequencing. Gene construction and expression have been demonstrated. A remaining obstacle to the practical utility of the CBP method is affordable polymerizable tagging phosphoramidites (PTPs) that are needed for the method. In this article, we report scalable synthesis of the four nucleoside (dA, dC, dG and dT) precursors to the PTPs using a route having six steps from inexpensive starting materials. The overall yields ranged from 21% to 35%. The scales of the synthesis presented here are up to 2.1 grams of the precursors. Because the syntheses are chromatography-free, they are predicted to be readily scalable. With the precursors, the PTPs can be synthesized in one step using standard methods involving a chromatography purification.
Accuracy of projected atomic virtual orbital space in embedding applications
Authors: Szirmai Ádám B. , Barcza Bónis , Tajti Attila , Szalay Péter G.
Published: February 2024

The performance of the recently suggested projected atomic orbitals (PAO) approach as the virtual space in excited state projection-based embedding applications is analyzed. The role of the parameters in the PAO generation is discussed and the impact of different choices is evaluated on the ground state of the stacked formaldehyde and pyrrole dimers. A comparison of excitation energies obtained with PAOs and localized virtual orbitals is given and the role of diffuse basis functions is discussed using a benchmark set from previous studies.
Improving the chemical profiling of complex natural extracts by joint 13C NMR and LC-HRMS2 analysis and the querying of in silico generated chemical databases
Authors: CORDONNIER Julien , REMY Simon , Kotland Alexis , LEROY Ritchy , DARME Pierre , Bertaux Benjamin , Sayagh Charlotte , Martinez Agathe , Borie Nicolas , HUBERT Jane , Aubert Dominique , Villena Isabelle , Nuzillard Jean-Marc , Renault Jean-Hugues
Published: February 2024

The chemical profiling of complex natural mixtures emerges as a pivotal avenue of investigation for the discovery of new bioactive compounds. It requires a dereplication step generally based either on liquid chromatography-high resolution tandem mass spectrometry (LC-HRMS2) or on nuclear magnetic resonance (NMR) to quickly identify known compounds. The high sensitivity of MS results in numerous but sometimes incorrect candidate compounds, whereas the greater universality of NMR leads to fewer but more accurate annotations. These two analytical techniques are rarely used in combination despite their complementarity. This study focuses on the chemical profiling of Larix decidua (Pinaceae) bark by joint LC-HRMS2 and 13C NMR data analysis and by querying custom in silico-generated chemical databases. MS-based dereplication allowed the annotation of 135 MS2 spectra with at least two different annotation tools. Twenty-five compounds were annotated in parallel by NMR spectra analysis, including two previously undescribed myrtenic acid derivatives. Sixteen of these compounds were already reported in the Pinaceae family. Twelve compounds were jointly annotated with a high confidence level by comparing LC-HRMS2 and 13C NMR dereplication results, including compounds not reported to date in Larix decidua. Our results show the benefits brought by combining LC-HRMS2 and 13C NMR data and by querying custom in silico chemical databases to enhance the confidence level of data annotation during the chemical profiling of complex natural extracts.