bluuebunny/crossref_metadata_2025 huggingface dataset:
Achieving Depth of Response in Skin Clearance and Itch Relief With Lebrikizumab is Associated With Minimal Impact of Atopic Dermatitis on Quality of Life
Authors: Chovatiya Raj , Simpson Eric , Biedermann Tilo , Kircik Leon , Shi Vivian Y. , Figueras-Nart Ignasi , Casillas Marta , Gallo Gaia , Ding Yuxin  , Zhang Hong  , Pierce Evangeline  , Agell Helena  , Vestergaard Christian 
Published: January 2025

In Phase 3, monotherapy trials, ADvocate1 (NCT04146363) and ADvocate2 (NCT04178967), Week 16-responders treated with lebrikizumab (LEB) every 2 weeks (Q2W) and every 4 weeks (Q4W) demonstrated extended maintenance of deep response in skin clearance and itch improvement. In this post hoc analysis of ADvocate1/-2, among LEB responders (defined by achieving Investigator’s Global Assessment [IGA] 0 or 1 with ≥2-point improvement or ≥75% improvement in the Eczema Area and Severity Index [EASI75], and not receiving rescue medication, including topicals, at Week 16), we evaluated quality of life (QOL) improvements for patients who achieved a deep response to LEB at Week 52, defined as: IGA score 0 (clear skin); ≥90% or 100% reduction in EASI (EASI90; EASI100); or Pruritus Numeric Rating Scale (PNRS; 0-10, none to worst itch imaginable) scores 0 or 1 (PNRS01) at Week 52. QOL was assessed by the Dermatology Life Quality Index (DLQI), scored 0–30, with higher scores indicating a worse effect of AD on QOL (scores ≤5: no/minimal effect; scores ≥11: very large/extremely-large effect). Descriptive analyses using as-observed data were reported at baseline (Week 0) and Week 52 for deep responders regardless of treatment arm (pooled) and by treatment arms separately. For patients with IGA0 at Week 52, mean (SD) DLQI scores decreased from 14.0 (7.5) at baseline to 1.8 (2.7) at Week 52 in the pooled dataset (Nx=73) and from 12.6 (7.9) to 1.6 (2.8) for LEBQ4W (Nx=32). For patients with EASI90 at Week 52, the scores decreased from 14.6 (7.3) to 2.6 (3.3) in the pooled dataset (Nx=151) and from 14.4 (7.5) to 2.4 (3.3) for LEBQ4W (Nx=67). For patients with EASI100 at Week 52, the scores decreased from 13.9 (7.4) to 1.9 (2.8) in the pooled dataset (Nx=68) and from 12.8 (8.2) to 1.6 (2.9) with LEBQ4W (Nx=29). For PNRS01, the scores decreased from 14.1 (6.8) to 1.4 (1.9) in the pooled dataset (Nx=80) and from 14.1 (7.5) to 1.3 (2.3) with LEBQ4W (Nx=36). Deep response in skin clearance and itch relief was achievable with LEB and was associated with substantial improvement in QOL to levels indicating minimal-to-no impact of AD on QOL.
Evidence-Based Data on How Long to Treat to Achieve Treatment Response With Baricitinib in Severe Alopecia Areata
Authors: King Brett , Senna Maryanne , Ohyama Manabu , Sinclair Rodney , Somani Najwa , Dutronc Yves , Lu Na , Chen Yun-Fei , Jedynak Jakub P. , Buchanan Andrew , Piraccini Bianca M.
Published: January 2025

Introduction: Previous data on baricitinib treatment in severe alopecia areata (AA) has shown that treatment response varies by baseline disease severity and by duration of current episode.  In general, hair regrowth response varies, and clinicians lack data on how long to optimally treat patients to achieve response.   
In the literature, time to onset of improvement (defined as 30% improvement from baseline SALT score, i.e. SALT30 can predict ultimate achievement of SALT score ≤20 by Week 52. In this analysis, we evaluated improvement(SALT30) and meaningful response(SALT score ≤20), in clinically relevant subpopulations to characterize time required to treat patients based on their disease presentation.   
Procedure: Patients randomized to treatment with baricitinib 4mg daily for up to 52 weeks were evaluated from the pooled BRAVE AA1/AA2 phase 3 trials according to four clinically relevant subpopulations divided by baseline SALT score (severe: 50-94; very severe: 95-100) and current AA episode duration (<4 years; >4 years).  
Patients achieving SALT30 improvement across visits was evaluated for each subpopulation.  Among those achieving SALT30, proportion of patients achieving SALT score ≤20 through Week 52 was evaluated at the timepoint during which SALT30 improvers began to plateau. Non- Responder Imputation was used for the missing SALT30 and SALT score ≤20. 
Results: Among subpopulations with baseline severe AA, the proportion of SALT30 improvers plateaued between 24weeks (61-70%) and 36 weeks (63%-73%) of treatment. Among those who reached SALT30 improvement at Week 24, achievement of SALT score ≤20 at Week 52 was 75% vs. 65%, respectively among those with < 4 years vs. > 4 years duration of current episode.  
In the baseline very severe AA group, the proportion of SALT30 improvers continued to increase through 52 weeks without plateau. 
Discussion: This data suggests that 'how long to treat’ with baricitinib 4 mg monotherapy can be tailored to patient baseline characteristics.  Evidence of improvement (SALT30) is seen relatively early among those patients with baseline severe SALT score(50-94). Most who achieve improvement at 6 months achieve clinical response (SALT score < 20) within a year of treatment. This suggests that if improvement is seen by 6 months, treatment should be continued to achieve optimal outcomes.   
Patients with a very severe SALT score (95-100) at baseline (i.e. alopecia totalis or universalis) show continuing (SALT30) improvement up to 1 year. Very severe AA may need at least 1 year to see evidence of treatment effect before considering a stop or switch in therapy, and longer treatment may be required in some improvers to achieve optimal outcomes.
Development of telecommunications in the Arctic regions of the Sakha Republic (Yakutia)
Authors: Semenova V. V. , Petrova A. A. , Dmitriev M. M.
Published: January 2025

The article examines the prospects and directions for the development of communications in the Arctic regions of the Republic of Sakha (Yakutia), where ensuring stable and high-quality communications is critical for the social and economic integration of the region, as well as for improving the standard of living of the local population. The paper analyzes the current state of the telecommunications infrastructure, covering satellite, mobile and fiber-optic networks, with a special focus on the key challenges faced by residents of remote areas: high costs of services, complex logistics and limited availability of broadband Internet. The article also considers federal and regional programs, such as the Arctic Synergy project and the Polar Express underwater communication line, aimed at improving telecommunications coverage, eliminating digital inequality and reducing social isolation in remote areas. Technological solutions are proposed, including the introduction of 4G and 5G networks, the use of satellite systems and the integration of renewable energy sources, which are assessed as strategic approaches that can improve the quality of services and support the development of digital infrastructure. In conclusion, the authors point out that sustainable development of communications in the Arctic requires not only the introduction of modern technologies, but also continued government support, including subsidies to reduce the cost of services. They also emphasize the importance of developing infrastructure adapted to extreme climatic conditions and creating backup communication channels that will ensure the reliability and stability of telecommunications services in remote Arctic regions.
Signs of polar T3 syndrome in young men in Yakutia
Authors:   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Nikanorova A.A. , Barashkov N.A. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Pshennikova V.G. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Nakhodkin S.S. ,   scientific researcher of the Research Laboratory of Molecular Biology Institute of Natural Sciences, Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov North-Eastern Federal University, Fedorova S.A. ,   Doctor in Biology, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences, Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov North-Eastern Federal University
Published: January 2025

The aim of the study was to search for seasonal variations in the levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) in young men in Yakutia, where there are strong changes in climatic parameters in the winter-spring period (from -41.8°C to -0.2°C). Seasonal variations between winter and spring were found for fT3, where in winter its levels were lower – 6.48±0.31 pmol/L than in spring – 6.88±0.1 pmol/L (p=0.005). There were no statistically significant seasonal variations for TSH (U=97; p=0.914) and sv.T4 (U=47; p=0.112). Winter-spring seasonal variations of fT3 detected in this study there are signs of polar T3 syndrome in young men in Yakutia. To search for the causes of the detected seasonal variation, a correlation analysis of the levels of TSH, fT3 and fT4 was carried out depending on daylength and atmospheric air temperature. As a result, a correlation between fT3 and fT4 with the daylight (fT3: R=0.339, p=0.03; fT4: R=-0.346, p=0.01) and with air temperature (fT3: R=0.295, p=0.05; fT4: R=-0.296, p=0.04). No correlations were found with TSH levels (daylight: R=-0.06, p=0.69; air temperature: R=-0.09, p=0.559). Thus, the residents of Yakutia have signs of polar T3 syndrome, which can be associated with both a short light day and low atmospheric temperatures in winter. The results obtained may indicate an increase in the absorption of T3 at the tissue level when exposed to cold.
Keywords: thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), Yakutia, polar T3 syndrome.
Association of polymorphism rs1495741 of the NAT2 gene and the risk of developing inflammatory liver diseases under the influence of external factors
Authors:   Junior Research Officer at the Research Institute of Biomedical Technologies of Irkutsk State Medical University, Peretolchina N.P. , Stepanenko L.A. ,   PhD, Senior Research Officer at the Research Institute of Biomedical Technologies, Irkutsk State Medical University, Kiselyov D.O. ,   Junior Research Officer at the Research Institute of Biomedical Technologies of Irkutsk State Medical University, Davydova A.V. ,   PhD, head of the Department of hospital therapy of Irkutsk State Medical University, Kravchenko S.D. ,   assistant lecturer of the Department of Faculty Therapy of Irkutsk State Medical University, Malov I.V. ,   MD, professor, head of the Department of Infectious Disease of the Irkutsk State Medical University, Ogarkov O.B. ,   MD, professor, Head of the Department of Epidemiology and Microbiology, Scientific Centre for Family Health and Human Reproduction Problems
Published: January 2025

Slow acetylation of substrate is associated with drug-induced liver damage and transformation of viral and alcohol hepatitis in cirrhosis. Increasing xenobiotic load is a significant factor in development of metabolic associated liver diseases. This interaction between genotype and environment should be studied to reveal disease pathogenesis. We analysed polymorphism rs1495741 genotypes in control group and in patients with cryptogenic liver cirrhosis and non-alcohol fatty liver disease to evaluate association of acetylation type with liver disease development. As part of the study, patients filled the questionnaire to assess xenobiotic load. The rs1495741 polymorphism was detected by real-time PCR. Significant differences were revealed in the criptogenic liver cirrhosis and non-alcoholic fatty liver disease groups in patients consuming fried and smoked foods (OR: 5,49 at p<0,05); in combination with older age (>55) the risk increases by 7.57 times (p<0,05). However, no association of the rs1495741 polymorphism with the development of liver diseases was identified.
Keywords: N-acetyltransferase 2, polymorphism, cryptogenic liver cirrhosis, non-alcoholic fatty liver disease.
АНАЛИЗ СОВРЕМЕННЫХ SCADA-СИСТЕМ И ИХ ПРИМЕНЕНИЕ В ПРОМЫШЛЕННОСТИ
Authors: ЕРЕМИНА Е Л. , СИЛАЕВ А А. , ЕФРЕМКИН С И. , МАСЛОВА Т А.
Published: January 2025

В статье анализируются современные системы диспетчерского управления и сбора данных (SCADA), рассматриваются их функциональные возможности, достижения и расширяющиеся возможности промышленного применения. В статье рассматриваются взаимосвязанные компоненты, такие как полевые устройства, PLCs, коммуникационные сети, центральные серверы и HMI. Подчеркивается важность передовых коммуникационных протоколов и расширения возможностей SCADA-систем за счет интеграции с принципами промышленного Интернета вещей, облачных вычислений и алгоритмов искусственного интеллекта и машинного обучения. В статье рассматривается растущий спектр применения современных SCADA-систем, демонстрируется их роль в производстве и распределении электроэнергии, перерабатывающих производствах, установках очистки воды, очистных сооружениях для отходов и системах автоматизации зданий. Уделяя особое внимание тому, как системы SCADA достигают исключительной эффективности, надежности и безопасности, в статье подчеркивается их значение для развития современной промышленной автоматизации.

The article analyzes modern dispatch control and data acquisition (SCADA) systems, examines their functionality, achievements and expanding industrial application possibilities. The article discusses interconnected components such as field devices, PLCs, communication networks, central servers and HMI. The importance of advanced communication protocols and expanding the capabilities of SCADA systems through integration with the principles of the industrial Internet of Things, cloud computing and artificial intelligence and machine learning algorithms is emphasized. The article examines the growing range of applications of modern SCADA systems, demonstrates their role in the production and distribution of electricity, processing plants, water treatment plants, waste treatment plants and building automation systems. Paying special attention to how SCADA systems achieve exceptional efficiency, reliability and safety, the article highlights their importance for the development of modern industrial automation.
О РАЦИОНАЛЬНОМ ВЫБОРЕ ПАРАМЕТРОВ ДВИЖЕНИЯ НОСИТЕЛЯ ПОИСКОВОЙ ВОЗДУШНОЙ ТЕПЛОВИЗИОННОЙ АППАРАТУРЫ
Authors: ОВСЯННИКОВ В А. , ОВСЯННИКОВ Я В.
Published: January 2025

Разработан методологический подход и соответствующая математическая модель для оперативного рационального выбора параметров, характеризующих тактику применения воздушной тепловизионной аппаратуры (ВТА) смотрящего типа, - высоты и скорости движения ее носителя, а также угла визирования ВТА, - которые обеспечивают максимальную вероятность обнаружения и/или распознавания объемных или плоских объектов местности при визуальном дешифрировании в режиме реального времени тепловизионных изображений этих объектов при ограниченном времени осмотра зоны поиска, определяемом решаемой задачей. Установлено, что с увеличением этого времени оптимальная высота носителя ВТА уменьшается, а его оптимальная скорость возрастает. При этом в случае поиска объемных объектов угол отклонения оси ВТА, отсчитываемый от надира в направлении полета носителя, должен быть по возможности максимальным, однако при поиске плоских объектов эффективнее использование их визирования в надир. На конкретном примере проиллюстрирована практическая реализация полученных результатов.

A methodological approach and a corresponding mathematical model have been developed for an quick and rational choice of parameters that characterize the tactics of using viewing-type aerial thermal imaging equipment (FLIR) - the height and speed of movement of its carrier and its viewing angle -which provide the maximum probability of detection and/or recognition of volumetric or flat objects of the terrain during real-time visual interpretation of thermal images of these objects with a limited inspection time of the search zone determined by the problem being solved. It is shown that with an increase in this time, the optimal height of the FLIR carrier decreases, and its optimal speed increases; in the case of searching for voluminous objects, the axis of the FLIR should be moved forward as much as possible; flat objects should be sighted at nadir. The practical implementation of the obtained results is illustrated by a specific example.
АЛГОРИТМ ФУНКЦИОНИРОВАНИЯ АГЕНТОВ ОБНАРУЖЕНИЯ И ЛОКАЛИЗАЦИИ ОТКАЗОВ БОРТОВОЙ СИСТЕМЫ
Authors: ТАРАСОВ А Г. , МУСИЕНКО А С.
Published: January 2025

Важное значение в современной разработке и эксплуатации космических аппаратов заключается в обеспечении необходимой автономности, оперативности и эффективности их функционирования в различных условиях. Необходимость выполнения этих задач космическим аппаратом обусловлена, с одной стороны, особенностями орбиты, на которых он выполняет целевые задачи, и, с другой стороны, невозможностью осуществления технического контроля в случае возникновения аварийной ситуации. Орбиты, на которых эксплуатируются космические аппараты, обладают своими особенностями, которые ставят под сомнения возможность осуществления технического контроля в реальном времени, создавая необходимость в применении автономных систем, способных обеспечить надежную и продолжительную работу технических устройств без прямого воздействия наземных комплексов. Для обеспечения автономности космического устройства необходимо иметь возможность оперативного восстановления его функциональности...

An important aspect in the modern development and operation of spacecraft is to ensure the necessary autonomy, efficiency and efficiency of their functioning in various conditions. The need to perform these tasks by a spacecraft is determined, on the one hand, by the characteristics of the orbit in which it performs the target tasks, and, on the other hand, by the impossibility of carrying out technical control in the event of an emergency. The orbits in which spacecraft are operated have their own characteristics that cast doubt on the possibility of carrying out technical control in real time, creating the need for the use of autonomous systems capable of ensuring reliable and long-term operation of technical devices without direct influence from ground-based systems. To ensure the autonomy of a space device, it is necessary to be able to quickly restore its functionality. This implies the ability to change the operation algorithms of spacecraft depending on the available resources of the backup system under various conditions in order to maintain their functionality...
ОРАТОРИЯ "ИСААК" В ЦЕРКВИ СВ. ФОМЫ: К ИСТОРИИ МУЗЫКИ ЛЕЙПЦИГА В СЕРЕДИНЕ XVIII ВЕКА
Authors: ШАБАЛИНА Т В.
Published: January 2025

Статья посвящена найденному в Российской национальной библиотеке источнику страстной оратории «Исаак», исполненной в лейпцигской церкви Св. Фомы в 1754 году. Показано, что оригинальное печатное либретто выявляет неизвестный ранее факт истории музыки города и свидетельствует о сочинении Иоганна Генриха Ролле (1716-1785), представленного на Страстную пятницу того года. В статье исследуются все детали обнаруженного экземпляра, дается анализ его текста и сравнение с партитурой оратории, хранящейся в Государственной библиотеке Берлина, на основе чего делается вывод о той версии произведения, которая прозвучала в Лейпциге под управлением Готлоба Харрера (1703-1755). Разработана хронология исполнения пассионов и страстных ораторий в период, охватывавший последние годы творчества Иоганна Себастьяна Баха (1685-1750) и деятельность его непосредственных преемников, что позволяет проследить изменения в истории развития музыкальных традиций Лейпцига в 1740-1750-е годы...

The article is devoted to a source of a Passion Oratorio «Isaac» found in the National Library of Russia which gives evidence of a work performed in 1754 at Leipzig St. Thomas church. It is shown, that the original printed libretto reveals a hitherto unknown fact of the music history of the city and belongs to the oratorio by Johann Heinrich Rolle (1716-1785), presented on Good Friday of that year. All the details of the found source are studied; its text and comparison with the score of the work kept at the State Library of Berlin are analyzed; basing on this research the conclusion about the version performed in Leipzig under Gottlob Harrer (1703-1755) is drawn. The chronology of performances of Passions and Passion Oratorios in the period covered the late years of the life of Johann Sebastian Bach (1685-1750) and activity of his direct successors is elaborated that allows to trace essential changes in the history of musical traditions development in Leipzig in the 1740-50s years...
Flame Resistant Polyurethane PolyHIPEs Stabilized with Graphene
Authors: Chen Feiyang , McDermott Sean T. , Liyanage Chinthani D. , Brown Elizabeth E. B. , Mahmoudi Mahdad , Adamson Douglas H.
Published: January 2025

This study introduces an approach for synthesizing polyurethane (PU) high internal phase emulsions (HIPEs) using graphene as a 2D surfactant to stabilize water-in-oil (w/o) emulsions. An emulsion sys-tem comprising a calcium chloride-saturated aqueous solution, dry acetone solution, and pristine graphite is employed to mitigate common challenges in PU HIPE fabrication, such as void formation from water-isocyanate side reactions. The resulting graphene-stabilized PU HIPEs exhibit a uniform cellular structure with tunable cell sizes dependent on graphite loading. Incorporating graphene at the emulsion interface reduces interfacial permeability and enhances the flame retardancy of the PU foams, achieving V-0 classification in UL94 vertical flammability tests. These findings demonstrate the ability to produce robust, non-flammable PU polyHIPEs with customizable architectures and broader applicability across diverse polyol systems. This work lays the groundwork for advancing lightweight, flame-resistant materials for industrial and commercial applications.
The Role of Colloidal Quantum Dots Capping Ligands in Photocatalytic Lignin Valorization
Authors: Rico Elio , Marset Xavier , Pastor Francisco J. , Montilla-Verdú Salvador , Lan Wu , Yao Liang , Guijarro Néstor
Published: January 2025

The efficient transformation of biomass into high-value chemicals remains a significant challenge, with surface ligand manipulation offering a promising approach to enhance catalytic performance. In this study, we investigate the role of organic ligands in the photocatalytic conversion of lignin into functionalized aromatics using cadmium sulfide (CdS) quantum dots (QDs). By tuning the hydrophilicity/hydrophobicity of ligands, we successfully form stable QD colloidal solutions, ensuring effective contact between the QDs and lignin. We determined that thiyl ligands triggered the photocatalytic conversion of lignin models. These ligand modifications, including the anchor group and alkyl chain length, are shown to play a critical role in facilitating electron transfer during photocatalysis. Furthermore, it was discovered that the mechanism of C-C and C-O bond cleavage at the β-O-4 linkages can be influenced by the substituents on the aromatic rings of lignin, a finding that has not been previously reported. Our findings not only advance the understanding of ligand-controlled catalysis but also present a new pathway for efficient lignin biomass valorization and organic transformation processes using QD-based photocatalysts.
Triple Top Line Thinking for Triple Bottom Line Performance: Reflections on Outcomes of CCTU Eco-Guesthouse Business Plan Development
Authors: Agyefi-Mensah S. , Kissi M. , Attom B. E. , Slonimpah G.
Published: January 2025

Purpose: Using the case of a DAAD-sponsored Eco-Guesthouse project at Cape Coast Technical University, the study analysed the outcomes of a business plan development based on the reflective experiences of participants and stakeholders.
Design/Methodology/Approach: The study was qualitative, following a phenomenological approach to inquiry. Structured interviews were used to collect data from a purposive sample of 12 participants and stakeholders. The data was analysed qualitatively using Constant Comparative Analysis (CCA).
Findings: The study found that, for start-ups, Triple Top Line thinking allows a proactive strategic view of business. This influences the choice of business model, the approach to business planning and development, and consequently, the value placed on the outcomes of the process. The study concludes that project outcomes in the form of resulting new knowledge, skills acquisition, changes in attitudes, and the development and strengthening of new and existing relationships from a system perspective constitute a useful, albeit tacit and fuzzy construct for evaluating project performance beyond tangible outputs.
Research Limitation: While the literature supports the number of participants and stakeholders (12) used for the study, the findings of such interview-based qualitative studies are often indicative, which limits the extent of generalisation.
Practical Implication: This study can help us understand the value of business plan development for startups' potential success.
Social Implication: The study shows that a TTL perspective of startups makes an integrated approach to business planning and development imperative and allows for interdisciplinary collaboration among stakeholders to achieve TBL performance.
Originality/Value: The paper theoretically demonstrates the inextricable linkage between triple bottom line thinking and triple bottom line performance in achieving project success and the significant place of outcomes in evaluating project performance from a systems point of view.
Nondestructive testing of railway embankments by measuring multi-modal dispersion of surface waves induced by high-speed trains with linear geophone arrays
Authors: Cunha Teixeira José , Bodet Ludovic , Dangeard Marine , Gesret Alexandrine , Hallier Amélie , Rivière Agnès , Burzawa Audrey , Cárdenas Chapellín Julio José , Fonda Marie , Sanchez Gonzalez Ramon , Dhemaied Amine , Boisson Gaboriau Joséphine
Published: January 2025

To effectively address engineering challenges and risks, it is crucial to characterize mechanical properties of near-surface environments. The Multichannel Analysis of Surface Waves (MASW) has proven to be a valuable active seismic imaging technique by providing near-surface shear (S)-wave velocities estimations. However, its application to urban areas requires further development. This study leverages well-constrained experimental sites to assess the viability of a passive-MASW technique, utilizing seismic waves induced by high-speed train traffic instead of conventional active sources. We suggest employing short 96-geophone uniform linear arrays to capture surface waves in a broad frequency band (10-200 Hz). Train passages are automatically detected and categorized regarding to the train travel direction. Seismic interferometry and phase-weighted stack techniques are applied to generate virtual shot-gathers that are transformed into high-resolution multi-modal dispersion images. Our results demonstrate a strong coherence between the picked dispersion curves from the passive-MASW approach and those obtained through traditional active MASW with a hammer source. We discuss the validity of higher modes and explore array density limits to ensure reliable results. Our findings highlight that seismic interferometry, coupled with a high phase-weighted stack power, effectively recovers energy at high frequencies, enhancing the characterization of multi-modal surface-wave dispersion associated with thin near-surface layers.
PENGEMBANGAN PLATFORM KNOWLEDGE MANAGEMENT DAN E-COMMERCE UNTUK PEMBERDAYAAN DESA
Authors: Gogor Arif Handiwibowo , Gita Widi Bhawika , Edwin Setiawan , Reni Nadlifatin , Fadila Isnaisi , Dominggo Bayu Baskara , Perdana Suteja Putra
Published: January 2025

The Association of Village Integrator Lecturers (ADIDES) was formed in response to the strong desire of academics (lecturers) to increase village capacity in serving their communities. The development of a digital platform in the form of the ADIDES website (adides.or.id) aims to increase academic collaboration and village economic empowerment through knowledge management and e-commerce. The background to this activity is the limited access of villages to intellectual resources, most of which are owned by universities. This community Service  activity was carried out intensively both online and offline in the first half of 2024. The fostered partners involved were ADIDES member-fostered villages in Surabaya and Sidoarjo. The results of the implementation of the activity showed that the ADIDES website succeeded in facilitating the storage and sharing of knowledge, strengthening academic collaboration, and supporting the marketing of village products through e-commerce features. The level of participation and user satisfaction showed the effectiveness of this platform in supporting community service activities. This shows that the ADIDES website is able to increase connectivity between the academic world and villages, although there are still challenges, such as limited internet access in some villages.
Reflections on the Construction of “Double-qualified” Teacher Team under the Background of School-Enterprise Community
Authors: Yi Kaining , Shen Hong , Zhang Xingmei , Li Aixiang
Published: January 2025

With the rapid development of vocational education, the construction of “double-qualified” teachers in higher vocational colleges has increasingly become the key to improve the quality of vocational education. This paper first discusses the connotation and importance of “double-teacher” teachers and then analyzes the current situation and dilemma of “double-teacher” teacher team construction under the background of the school-enterprise community, including structural problems, insufficient salary and treatment, career development path is not smooth and school-enterprise cooperation is not close. In response to these problems, this paper puts forward the construction paths of establishing career development and career planning system, strengthening the professional title evaluation mechanism and teaching assessment system, improving the salary and treatment level, deepening the school-enterprise cooperation mechanism, improving the teacher training mechanism and strengthening the policy support and guarantee. Through these measures, the aim is to promote the high-quality development of “double-qualified” teachers in higher vocational colleges, and provide a strong talent guarantee for vocational education.
Exploration of Teaching Practice and Reform of Emergency Management: Taking the Course of “Emergency Rescue and Disposal of Accidents” as an Example
Authors: Zhai Jiajie
Published: January 2025

In recent years, various types of accidents have occurred frequently, and the situation of emergency management has been grave. Major universities have launched emergency management-related majors, and the teaching quality needs to be enhanced. This paper conducts an exploration of the teaching practice and teaching reform of emergency management by taking the course “Accident Emergency Rescue and Disposal” as an example. Focusing on the training of professional talents in emergency rescue, this paper analyzes the problems existing in the teaching process of this core professional course based on teaching practice and puts forward corresponding suggestions for teaching reform.
Practice and Exploration of Ancient Characters Entering Junior High School Campus Based on the Core Quality of Chinese
Authors: Zhang Le , Xie Gaodi , Li Yuanyuan
Published: January 2025

As the source of Chinese characters, ancient characters contain profound cultural connotations. Ancient characters in the junior high school campus, for the inheritance of excellent Chinese traditional culture, improve the understanding of students’ Chinese characters, and enhance the core quality of students have a new value. Based on the cultivation of junior middle school students’ good Chinese core literacy, this paper conducts in-depth research and discussion on the significance and practical strategies of ancient Chinese characters entering junior middle school, to make the wind of ancient Chinese characters blow to every corner of the junior middle school campus so that it can be better carried forward and inherited in the new era.
Cultivating Global Competence Through Collaborative Online International Learning: Insights from Shanghai Jiao Tong University’s SDG July Camp
Authors: Guo Liang , Pittius Martina , Li Yunlei
Published: January 2025

Higher education institutions are faced with the challenge of developing global competence in students to prepare them for rapidly changing and interconnected world. This article provides insights from Shanghai Jiao Tong University’s (SJTU) experiences in delivering Collaborative Online International Learning (COIL) courses through its “SDG July Camp” program. It explores the challenges and takeaways in scaling up COIL courses as an institutional initiative, highlighting the importance of fostering global competence in higher education. SJTU’s SDG July Camp offers selected courses related to the United Nations Sustainable Development Goals (SDGs), providing students with opportunities to interact with peers from diverse cultural and disciplinary backgrounds and develop cross-cultural communication skills. The article also discusses the role of SDGs in promoting the internationalization of course content. It aims to contribute to the ongoing discourse on fostering global competence in university students and the effectiveness of COIL in achieving this goal.
Machine Learning Analysis of Happiness Factors in Koreans: Focus on Social Media Isolation and Trust
Authors:   The Korea Association Of Governance Studies, Jo Gyucheol
Published: January 2025

This study conducted an in-depth analysis of the factors influencing the happiness of Koreans by utilizing SHAP (SHapley Additive exPlanations), a machine learning-based XAI (eXplainable Artificial Intelligence) technique. We examined various variables -including job satisfaction, family life satisfaction, health satisfaction, and environmental satisfaction- to identify both linear and nonlinear relationships affecting happiness within complex contexts. Notably, the findings reveal that feelings of alienation experienced during SNS (Social Network Service) use negatively impact happiness, and that interpersonal trust is a key factor in mitigating this adverse effect. By performing individual-level predictions, we confirmed that the influence of the same variables on happiness can vary based on individual characteristics and contexts. These results suggest that policy efforts are needed to alleviate feelings of alienation from SNS use and to enhance interpersonal trust to improve personal happiness. The significance of this study lies in its precise and detailed discussion of the factors affecting the happiness of Koreans through machine learning.
Integration of Artificial intelligence into Ukrainian inclusive educational environment as an advanced learning tool
Authors: Potapiuk Liliia , Sasiuk Alina
Published: January 2025

Artificial intelligence (AI) is increasingly recognized as an advanced educational tool, supported by substantial evidence demonstrating its effectiveness in addressing educational challenges of varying complexity — from generating lesson plans with a single click to facilitating virtual excursions within classroom settings. Despite the current monopolistic tendencies among companies producing artificial assistive technologies, the digital market is anticipated to soon become saturated with a diverse array of generative agents of any needs and wallets. In the context of general pedagogy, positive trends in AI integration are evident. However, inclusive education remains largely anchored in traditional pedagogical approaches, primarily due to the challenges associated with making significant advancements in this low-mobility sector. Before any innovative steps can be undertaken, fundamental material needs must be addressed. A comparative analysis of the Ukrainian inclusive education experience against international benchmarks reveals a notable regression since the onset of the full-scale invasion. While leading international initiatives are focused on the potential of AI to address global educational challenges, Ukraine appears to depend largely on the initiatives of individual educators. To explore the contentious issue of whether it is acceptable to disregard certain recommendations from prominent state and international institutions regarding the safe integration of AI into educational practices — especially in the absence of alternative validated methodologies for teaching children with special educational needs — a survey was conducted involving 43 respondents engaged in inclusive education. The findings affirm that the negative perceptions surrounding AI in inclusive contexts are justified: Ukraine's educational landscape is still evolving to reach the technological standards observed in the early 2000s in other countries. This article also highlights the risks associated with the uncritical introduction of «radically new technologies» from the era of the first computers into educational settings without first ensuring compliance with four critical criteria: content accuracy, age appropriateness, relevance of pedagogical methods, and cultural and social suitability. While the article predominantly conveys a skeptical perspective on the feasibility of effectively integrating AI into the inclusive educational process, the authors do not intend to diminish national accomplishments. Instead, they advocate for a research trajectory that is genuinely pertinent: Ukraine's journey with AI should be collaborative, aiming to refine tools that empower, rather than replace, ensuring that «artificial inclusion» becomes a lived reality rather than a tick-box culture.
Functional significance of coronary artery stenosis: the role of arterial hypertension (literature review)
Authors: Mordovin V. F. , Lichikaki V. A. , Pekarsky S. E. , Zyubanova I. V. , Manukyan M. A. , Solonskaya E. I. , Popova A. A. , Khunkhinova S. A. , Skomkina I. A. , Soltanakhmetova A. D. , Falkovskaya A. Yu.
Published: January 2025

Arterial hypertension (AH) is currently considered as the main risk factor for the development of atherosclerosis of the epicardial arteries, contributing to the formation of not only structural, but also functional changes in the coronary vessels, including at the level of microcirculation.

Aim: To assess the influence of coronary microvascular dysfunction (CMD) of hypertensive origin on the functional significance of stenoses of the main coronary arteries according to measurements of fractional flow reserve (FFR), as well as to analyze the mechanisms of CMD formation in patients with coronary heart disease in combination with hypertension. The FFR measurement method is considered as a standard for making decisions about myocardial revascularization, which can increase the effectiveness of the intervention. However, the results available to date are still ambiguous, as evidenced by the results of numerous meta-analyses presented in the work. Equally important is the assessment of the independent unfavorable prognostic value of CMD, which makes it urgent to develop new targeted treatment methods that reduce the severity of these disorders.
Examining IT Infrastructures for Learning and Teaching in the European University Alliance Unite!
Authors: Schön Sandra , Ebner Martin , Alcober Jesus , Bertonasco Roberto , Herczak-Ciara Agnieszka , Hoppe Christian , Langevin Etienne , Gasplmayr Katharina , Reignier-Tayar Nina , Martikainen Juha , Laurent Romain , Leitner Philipp , Petersson Joakim , Mira da Silva Fernando , Steitz Klaus , Taraghi Behnam , Wuerz Astrid
Published: January 2025

In the digital era, European University Alliances like "Unite!" work to reshape tertiary education by bridging nine prominent universities to champion regional integration, technology transfer, and quality science and engineering education. This paper delineates the methodologies used to harmonize varied IT infrastructures visualizations and descriptions across partner institutions, fostering knowledge sharing and facilitating standardized IT landscape comparisons. The absence of a general universal approach in representing teaching-related IT systems in higher education propelled the development of a unique, synchronized representation methodology. The paper offers a look at TU Graz's digital infrastructure as an illustrative example. Through iterative collaboration, the alliance will develop a comprehensive IT infrastructure report, aiming to serve as a valuable blueprint for other educational entities.
EU-Wallets, Security and Trust for HEI/EDU lifecycle
Authors: Strack Hermann , Bacharach Guido , Schmidt Carsten , Pongratz Hans , Gottlieb Matthias , Stanić Mirko , Lierath Michael , Waßmann Arn , Kleinert Björn
Published: January 2025

The EU regulation eIDAS 2.0 requires the implementation of an EU-wallet for every citizen with a PID cross border, QeS signing options and attestations, also for HEI/EDU purposes and applications, with SDG cross border. We consider extension approaches for security, privacy and trust at these process and infrastructure environments.
Building UniGPT: A Customizable On-Premise LLM-Solution for Universities
Authors: Radas Jonathan , Risse Benjamin , Vogl Raimund
Published: January 2025

Large Language Models (LLMs) have become the hot topic in Artificial Intelligence (AI) in the last few years, especially with the advent of the Generative Pretrained Transformer (GPT) models and the release of ChatGPT in November 2022. Demand from faculty members for access to such models quickly arose and proved to be hard to address in an orderly manner by central IT providers due to technical, privacy and payment constraints by the major suppliers. Additionally, specific research questions might require more control over the model and deployment. Thus, access to non-public on-premises models became desirable and became possible with open-source solutions (e.g. Llama 2 by Meta and Mixtral 8x7B by Mistral AI). Due to the large model sizes, on-premises deployments are demanding in terms of hardware and system engineering. In this paper, we present our deployment of a large language model for the University of Mu ̈nster, a service we call UniGPT. We focus on the high-level architecture, consisting of the frontend, backend, and models, and also discuss the experiences with our deployed service.
Principles, organisation, and methods of digitally transformed universities
Authors: von der Heyde Markus , Hartmann Andreas , Goebel Matthias , Bochmann Tobias
Published: January 2025

Higher education institutions (HEIs) face challenges in adopting digital practices. Neither newly founded nor existing institutions can yet be considered digitally transformed. One important reason for this is the lack of experts which are capable of driving digital transformation (Dx). This shortage of skilled labour for Dx is not only visible in HEIs but throughout society. The solution to this shortage may lie in providing qualified teaching of Dx at the university level in a highly digitised ecosystem that applies Dx to itself. Experiencing digital transformation in problem-based learning scenarios can facilitate a deeper understanding of the methods involved. Breaking up academic programmes into smaller learning units may facilitate lifelong learning and professional development, particularly for experienced individuals. This paper presents the organisational, educational, and scientific perspective of the Digital University (DU) as a mature digital ecosystem which implements this vision for society. The highly interrelated principles between the core functions of the DU enable optimal growth as well as financial and environmental sustainability. The paper discusses bootstrapping new institutions as well as transforming existing universities into this digital ecosystem. In consequence, this paper envisions the DU as a realistic future scenario, which might develop a disruptive power enabling Dx for all HEIs in the long run.
An educational studio for quality multimedia content - A successful delivery of IT practices
Authors: Charidimou Dimos , Roussos Georgios , Agorogianni Angeliki , Patsinakidou Anthoula , Nikolaidis Stavros , Christopoulos Evangelos
Published: January 2025

The Information Technology (IT) Center of Aristotle University of Thessaloniki (AUTh), in the context of the digital transformation of education, developed a studio to produce quality learning multimedia material. With the appropriate creation of multimedia resources, learning can be facilitated whether it is face-to-face, online, or even hybrid education. This paper deals with the construction of an educational studio as well as the creation of a new service to produce added-value multimedia material for the academic community of AUTh. The studio serves a dual purpose:

Creating high-quality, learner-centered audiovisual educational materials ensures students receive engaging and comprehensive content tailored to their learning needs. Supporting a wide range of university activities. This includes interviews, promotional videos, events, conferences, and more. By capturing and sharing these activities, the studio strengthens the university's outward engagement and visibility.

This transformative project stands as a testament to the IT Center's strategic foresight in adapting to the evolving educational landscape, particularly after the COVID-19 pandemic.
National registries for life-long learning infrastructure in Norway
Authors: Vangen Geir Magne , Haugen Anne Kathrine
Published: January 2025

The Norwegian Government's Skills Reform (2020) - Lifelong Learning aims to ensure continuous skill enhancement to prevent obsolescence in the workforce. A significant measure in the reform is the establishment of a digital competence ecosystem to address the societal challenge of a widening skills gap. This paper discusses the development of the ecosystem, the challenges in the current situation, the needs of the target group, and the incorporation of various registers to facilitate lifelong learning.

The ecosystem aims to provide holistic and seamless user experiences, facilitate data accessibility, and promote closer interaction between the workforce and education providers. Despite a high level of education and a rich learning environment, rapid changes in the labour market necessitate continuous knowledge updating. However, a decreasing trend in training participation, especially among individuals with low formal education, presents a challenge.

This paper discusses some central components of a platform for lifelong learning, national registries, and certain services to enable such an ecosystem: A National Education Registry, a Learner Registry and Result registries. These registers will provide comprehensive overviews of formal educational offerings, collect, and verify digital credential data, an authoritative registry for individuals in education, and provide a framework for retrieving and sharing academic results, respectively. The development and establishment of this competence ecosystem for lifelong learning is a collaborative effort involving both public and private actors.