bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in the Hemagglutinin and Internal Gene Segments Were Needed for Human Seasonal H3 Influenza A Virus to Efficiently Infect and Replicate in Swine
Authors: Rajao Daniela , Abente Eugenio , Powell Joshua , Bolton Marcus , Gauger Phillip , Arruda Bailey , Anderson Tavis , Sutton Troy , Perez Daniel , Vincent Baker Amy
Published: August 2022

The current diversity of influenza A viruses (IAV) circulating in swine is largely a consequence of human-to-swine transmission events and consequent evolution in pigs. However, little is known about the requirements for human IAVs to transmit to and subsequently adapt in pigs. Novel human-like H3 viruses were detected in swine herds in the U.S. in 2012 and have continued to circulate and evolve in swine. We evaluated the contributions of gene segments on the ability of these viruses to infect pigs by using a series of in vitro models. For this purpose, reassortant viruses were generated by reverse genetics (rg) swapping the surface genes (hemagglutinin-HA and neuraminidase-NA) and internal gene segment backbones between a human-like H3N1 isolated from swine and a seasonal human H3N2 virus with common HA ancestry. Virus growth kinetics in porcine intestinal epithelial cells (SD-PJEC) and in ex-vivo porcine trachea explants were significantly reduced by replacing the swine-adapted HA with the human seasonal HA. Unlike the human HA, the swine-adapted HA demonstrated more abundant attachment to epithelial cells throughout the swine respiratory tract by virus histochemistry and increased entry into SD-PJEC swine cells. The human seasonal internal gene segments improved replication of the swine-adapted HA at 33 °C, but decreased replication at 40 °C. Although the HA was crucial for the infectivity in pigs and swine tissues, these results suggest that the adaptation of human seasonal H3 viruses to swine is multigenic and that the swine-adapted HA alone was not sufficient to confer the full phenotype of the wild-type swine-adapted virus.
Assessing Preceptor and Student Perceptions of Remote Advanced Pharmacy Practice Experience Learning during the COVID-19 Pandemic
Authors: Kang-Birken S. Lena , Law Elaine J. , Moon Yong S. K. , Lee Audrey J. , Haydon Andrew L. , Shek Allen
Published: August 2022

The coronavirus disease 2019 pandemic created a major shift in learning modalities in the Advanced Pharmacy Practice Experience program. This descriptive study aimed to evaluate preceptor and student perceptions of remote learning experiences and student practice readiness upon completion of remote rotations. Preceptors and students who participated in partial to full remote experiential rotations between 17 August 2020 and 26 March 2021 were invited to complete an on-line survey. A cross-sectional survey consisted of closed-ended questions using a 5-point Likert scale assessing perception on adaptability, effectiveness of remote learning in advancing practice knowledge and skills, and confidence in students’ practice readiness. A total of 29 preceptors and 43 students completed the survey (response rates of 67% and 57%, respectively). Approximately 70% of the remote rotations were practice-based, with ambulatory care representing the most frequently reported rotation by preceptors (38%) and students (28%). A high level of confidence in preceptor perception of their ability to adapt and provide effective remote experiences (average 4.28) matched with the students’ high level of confidence with their preceptors’ abilities (86% agree or strongly agree). Upon the completion of remote rotations, both preceptors and students felt confident in student practice readiness based on student ability to design and initiate individualized patient care plans or complete projects using evidence-based resources (79% and 86%, respectively). Most preceptors (69%) reported that students achieved the rotation objectives at the same level as students engaged in-person experiences. The limitations of remote learning included the absence of direct interactions. Overall, both preceptors and students reported achieving practice readiness with remote experiential learning experiences and felt the remote activities should be continued post-pandemic.
Decoding Breast Cancer Metabolism: Hunting BRCA Mutations by Raman Spectroscopy
Authors: Kopec Monika , Romanowska-Pietrasiak Beata , Abramczyk Halina
Published: August 2022

Presented study included human blood from healthy people and patients with BReast CAncer gene (BRCA) mutation. We used Raman spectroscopy for BRCA mutation detection and the bioanalytical characterization of pathologically changed samples. The aim of this study is to evaluate the Raman biomarkers to distinguish blood samples from healthy people and patients with BRCA mutation. We demonstrated that Raman spectroscopy is a powerful technique to distinguish between healthy blood and blood with BRCA mutation and to characterize the biochemical composition of samples. We applied partial least squares discriminant analysis (PLS-DA) to discriminate BRCA1/2 mutations and control samples without the mutations based on vibrational features. The sensitivity and specificity for calibration obtained directly from PLS-DA are equal to 94.2% and 97.6% and for cross-validation are equal to 93.3% and 97%. Our combination (Raman spectroscopy and PLS-DA) provides quick methods to reliably visualize the biochemical differences in human blood plasma. We proved that Raman spectroscopy combined with the chemometric method is a promising tool for hunting BRCA mutation in breast cancer.
One KHz Order Narrow Linewidth Fiber Laser Using Rayleigh Backscattering Mechanism in an Additional Piece Optical Fiber
Authors: Wang Zi , Li Dong-Chang , Chen Geng-Ying , Wang Li-En , Liaw Shien-Kuei , Yeh Chien-Hung , Yu Yi-Lin , Tsai Hsiou-Hsin
Published: August 2022

A simple, low-cost, single-longitudinal mode, C-band narrow-linewidth optical fiber laser is presented based on the methodology of the Rayleigh backscattering (RBS). In this paper, a 1551 nm fiber ring laser is developed, and single-mode fiber (SMF) is added to compress the line width. When the SMF length of the RBS cavity is 120 m, the laser has better performance than that in other SMF lengths with a laser line width of 1.46 KHz with housing shield. The optical signal-to-noise ratio (OSNR) is 59.86 dB, and its maximum output power is 9.4 mW. It can quickly achieve the single longitude-mode operation by controlling the variable optical attenuator (VOA). The bit error rate at 10 Gb/s PRBS NRZ modulation is measured to be 10−9 when the optical receiving power is −16.2 dBm.
Ultrawideband and High-Resolution Terahertz Spectroscopy: Structural Identification of Glucose
Authors: Miyamoto Katsuhiko , Yamasaki Tomohito , Tsuji Shota , Inoue Kazuma , Park Godeung , Uchida Hirohisa , Matsuura Akira , Krüger Peter , Omatsu Takashige
Published: August 2022

We report on the development of an ultrawideband and high-resolution THz spectroscopic system, which operates over a frequency range of 2–13.5 THz. This work goes beyond conventional THz spectroscopic measurements and demonstrates the capacity to differentiate D- and L-glucoses, which have the same molecular conformation and crystal structure. Furthermore, this system facilitates the structural identification of glucose microcrystals, which exists in α- and β-forms, revealing that L-glucose microcrystals are formed of a mixture of α- and β-D-glucose with approximately equal weight.
Mixed-Matrix Membranes Based on Polyetherimide, Metal–Organic Framework and Ionic Liquid: Influence of the Composition and Morphology on Gas Transport Properties
Authors: Zid Sarra , Alcouffe Pierre , Zinet Matthieu , Espuche Eliane
Published: August 2022

In this work, membranes based on polyetherimide (PEI), a ZIF-8 metal–organic framework and 1-ethyl-methylimidazolium tetrafluoroborate ionic liquid (IL) were prepared. IL and ZIF-8 contents amounting to 7 wt% and 25 wt%, respectively, were investigated. CO2, He and H2 transport properties of PEI/IL/ZIF-8 membranes were compared to those obtained for the respective PEI/ZIF-8 and PEI/IL systems. Membranes’ gas permeability and selectivity are discussed as a function of the membrane composition and morphology, and they were assessed in relation to existing experimental and theoretical data from the literature. Promising gas transport properties were obtained using the appropriate combination of ZIF-8 and IL amounts in the PEI matrix. Indeed, an increase in the CO2 permeability coefficient by a factor of around 7.5 and the He and H2 permeability coefficients by a factor of around 4 was achieved by adding 7 wt% IL and 10 wt% ZIF-8 to the PEI matrix. Moreover, diffusion was evidenced as a governing factor in the studied membrane series.
Study on Dynamic Failure Characteristics of Coal and Rock in Stope Induced by Dynamic Load of Steep Horizontal Sublevel Mining
Authors: Wang Yongzhong , Yuan Chongliang , Shi Xianyuan , Chang Qingliang , Zhang Biao
Published: August 2022

In this paper, through a similar simulation experiment, the roof rock breaking situation of horizontal sublevel caving method in extremely thick and steep inclined coal seam is studied, and the response characteristics of coal and rock mass under different dynamic load strength are analyzed. The mechanical response mechanisms of different mining positions under the influence of dynamic load and the law characteristics of the surrounding rock from elastic deformation to impact failure are revealed. The study shows that with the increase in the horizontal sublevel mining depth, the roof is gradually broken from the suspended state, and the broken block fills the goaf. The thin rock strata form a granular structure, and the thick rock strata form a block splicing and occlusion structure. On the same side of the coal seam floor, the concentrated stress gradually increases, and the closer the distance from the goaf is, the more obvious the stress change in the coal body below is. With the increase in dynamic load energy, the dynamic instability and failure of the dynamic load side of the roadway occur, and the stress of the bottom coal in the intake roadway of the working face increases due to the influence of the lateral abutment pressure of the goaf, while the stress of the bottom coal in the middle of the working face and the return airway decreases due to the mining of the upper section, which reveals that the dynamic load-induced dynamic behavior requires the critical energy. Due to vibration waves, the dynamic load effect is short, and the reflective stretching is generated on the surface of the roadway, resulting in the failure of the roadway. The peak acceleration increases linearly with the increase in source energy, indicating that the stronger the dynamic load energy is, the higher the impact risk is. When the dynamic load intensity is constant, the peak acceleration decreases with the increase in propagation distance, indicating that the vibration wave has the dominant propagation direction, and there are certain directional differences in the effect of coal and rock. When the dynamic load is applied, the impact failure of the coal body has a critical displacement. When the displacement of the roadway surface is less than this critical displacement, the impact failure will not occur.
Validation of Pressure-Sensing Insoles in Patients with Parkinson’s Disease during Overground Walking in Single and Cognitive Dual-Task Conditions
Authors: Parati Monica , Gallotta Matteo , Muletti Manuel , Pirola Annalisa , Bellafà Alice , De Maria Beatrice , Ferrante Simona
Published: August 2022

There is a need for unobtrusive and valid tools to collect gait parameters in patients with Parkinson’s disease (PD). The novel promising tools are pressure-sensing insoles connected to a smartphone app; however, few studies investigated their measurement properties during simple or challenging conditions in PD patients. This study aimed to examine the validity and reliability of gait parameters computed by pressure-sensing insoles (FeetMe® insoles, Paris, France). Twenty-five PD patients (21 males, mean age: 69 (7) years) completed two walking assessment sessions. In each session, participants walked on an electronic pressure-sensitive walkway (GaitRite®, CIR System Inc., Franklin, NJ, USA) without other additional instructions (i.e., single-task condition) and while performing a concurrent cognitive task (i.e., dual-task condition). Spatiotemporal gait parameters were measured simultaneously using the pressure-sensing insoles and the electronic walkway. Concurrent validity was assessed by correlation coefficients and Bland–Altman methodology. Test–retest reliability was examined by intraclass correlation coefficients (ICC) and minimal detectable changes (MDC). The validity results showed moderate to excellent correlations and good agreement between the two systems. Concerning test–retest reliability, moderate-to-excellent ICC values and acceptable MDC demonstrated the repeatability of the measured gait parameters. Our findings support the use of these insoles as complementary instruments to conventional tools during single and dual-task conditions.
Traffic Aware Scheduler for Time-Slotted Channel-Hopping-Based IPv6 Wireless Sensor Networks
Authors: Deac Diana , Teshome Eden , Van Glabbeek Roald , Dobrota Virgil , Braeken An , Steenhaut Kris
Published: August 2022

Wireless sensor networks (WSNs) are becoming increasingly prevalent in numerous fields. Industrial applications and natural-disaster-detection systems need fast and reliable data transmission, and in several cases, they need to be able to cope with changing traffic conditions. Thus, time-slotted channel hopping (TSCH) offers high reliability and efficient power management at the medium access control (MAC) level; TSCH considers two dimensions, time and frequency when allocating communication resources. However, the scheduler, which decides where in time and frequency these communication resources are allotted, is not part of the standard. Orchestra has been proposed as a scheduler which allocates the communication resources based on information collected through the IPv6 routing protocol for low-power and lossy networks (RPL). Orchestra is a very elegant solution, but does not adapt to high traffic. This research aims to build an Orchestra-based scheduler for applications with unpredictable traffic bursts. The implemented scheduler allocates resources based on traffic congestion measured for the children of the root and RPL subtree size of the same nodes. The performance analysis of the proposed scheduler shows lower latency and higher packet delivery ratio (PDR) compared to Orchestra during bursts, with negligible impact outside them.
Resource Scheduling for Multitarget Imaging in a Distributed Netted Radar System Based on Maximum Scheduling Benefits
Authors: Hu Tianchen , Liao Kefei , Ouyang Shan , Wang Haitao
Published: August 2022

As a new radar system with improved performance, distributed multiple-input multiple-output (MIMO) radar provides a new idea for the development of netted radar. Aiming at the limited resource allocation problem of netted radar, this paper extends the idea of distributed MIMO radar to netted radar and proposes a resource scheduling algorithm for multitarget imaging in distributed netted radar based on the maximum scheduling benefits. Under the condition of the cognition of the target characteristics, the algorithm comprehensively considers the angle and dwell time to complete the multiradar and multitarget matching. Then it uses the principle of compressed sensing to calculate the pulse resources required for sparse imaging of each target on the corresponding radar. In this paper, the scheduling benefit of a radar system is expressed by weighting the three factors of the scheduling success rate, the hit value rate and the pulse resource consumption rate. The resource scheduling model is established according to the maximum scheduling benefits and solved using a heuristic algorithm. The simulation results show that compared with the traditional algorithm, this method improves the scheduling benefits of the radar system.
Practical Fast-Response Anodized-Aluminum Pressure-Sensitive Paint Using Chemical Adsorption Luminophore as Optical Unsteady Pressure Sensor
Authors: Oka Yoshinori , Nagata Takayuki , Kasai Miku , Ozawa Yuta , Asai Keisuke , Nonomura Taku
Published: August 2022

We developed and evaluated an anodized-aluminum pressure-sensitive paint (AA-PSP) with new formulations of free-base porphyrin, H2TCPP, as an optical unsteady pressure sensor. The luminophore H2TCPP has quite a short fluorescent lifetime (2.4 ns on the condition of the AA-PSP). The fluorescence spectroscopy result shows that the excitation wavelength of H2TCPP corresponds to violet-colored (425 nm) and green-colored (longer than 520 nm) lights. The pressure sensitivity is sufficiently high for the pressure sensor (0.33–0.51%/kPa) and the temperature sensitivity is very low (0.07–1.46%/K). The photodegradation of the AA-PSPs is not severe in both excitation light sources of the green LED and the Nd:YAG laser. The resonance tube experiment result shows the cut-off frequency of the AA-PSPs is over 9.0 kHz, and the results of the shock tube experiment show the 10 µs order time constant of the normal shock wave.
A Machine Learning Approach to Improve Ranging Accuracy with AoA and RSSI
Authors: Zhang Tingwei , Zhang Peng , Kalathas Paris , Wang Guangxin , Liu Huaping
Published: August 2022

Ranging accuracy is a critical parameter in time-based indoor positioning systems. Indoor environments often have complex structures, which make centimeter-level-accurate ranging a challenging task. This study proposes a new distance measurement method to decrease the ranging error in multipath environment. Our method uses an artificial neural network that utilizes the received signal strength indicator along with a signal’s angle of arrival to calculate the line-of-sight distance. This combination results in a significant reduction of the error caused by multipath effects that common RSSI-based methods suffer from. It outperforms traditional ranging methods while the implementation complexity is kept low.
The Effect of Selected Fruit (Apple, Bitter Orange and Grape) Juice Concentrates Used as Osmotic Agents on the Osmotic-Dehydration Kinetics and Physico-Chemical Properties of Pomegranate Seeds
Authors: Sebii Haifa , Bouaziz Mohamed Ali , Sghaier Khadija , Danthine Sabine , Blecker Christophe , Besbes Souhail , Attia Hamadi , Bchir Brahim
Published: August 2022

This work aimed to study the osmotic-dehydration kinetics of pomegranate seeds (PSs) (Punica granatum L.) using three fruit (apple, bitter orange and grape) juice concentrates as osmotic solutions (OSs) (ratio (1/4) m/v, 55° Brix, at 50 °C). The osmodehydration time, pomegranate-seed water loss, solute gain and weight reduction were determined during the osmodehydration process. The equilibrium time periods of osmodehydration were 20, 60, 80 and 60 min for sucrose solution, and bitter-orange, apple and grape juice concentrates, respectively. The physico-chemical, biological and textural properties of PSs were significantly affected by the changes in OS. At the end of osmodehydration, the dry-matter and the Brix values were higher in all fruit-based OSs compared with sucrose OS. The color of PSs became darker in apple and grape OSs and brighter in bitter-orange OS compared with sucrose OS. On the other hand, all osmodehydrated PSs showed important antioxidant activity, with seeds osmodehydrated in grape-juice OS attaining an IC50 of 49.25 meq GA/100 g DM. All observed changes were attributed to the difference in the composition of the different OS matrices. Moreover, the hedonic analysis showed that consumers preferred osmodehydrated PSs obtained using bitter-orange juice as OS.
Intercivilization dialogue in the projection of the "Axial time of history"
Authors:   Moscow State Institute of Culture, Remizov Vyacheslav Aleksandrovich
Published: August 2022

The article shows that the modern dialogical process between not only countries, but, most importantly, between civilizations is based on fundamental value and semantic platforms. The author demonstrates that different civilizations have different approaches to the implementation of communication and influence, and considers different groups of civilizations that have similarities and fundamental differences. The article may be useful within the framework of the training areas "International Relations", "Regional Studies", and "History".
Advertising as a broadcaster of Russian traditional, spiritual and moral values in the system of the 21st century visual culture development
Authors:   Moscow University for the Humanities, Sheryshova Lyubov Sergeevna
Published: August 2022

The article shows that the modern dialogical process between not only countries, but, most importantly, between civilizations is based on fundamental value and semantic platforms. The author demonstrates that different civilizations have different approaches to the implementation of communication and influence, and considers different groups of civilizations that have similarities and fundamental differences. The article may be useful within the framework of the training areas "International Relations", "Regional Studies", and "History".
Post-Covid era: the gates of global recession are opening
Authors:   Moscow University for the Humanities, Filimonova Anna Igorevna
Published: August 2022

The article identifies the reasons for the sharp deterioration in the global economic situation in the post-pandemic period. In particular, the article considers the new role of the IMF and the World Bank and the evolution of their approaches to debtor countries from the beginning of the introduction of the global quarantine regime to the present. Key points in the strategy of these financial institutions that do not allow debtors to get rid of the debt burden are highlighted. The systemic economic and political foundations of the current crisis in Sri Lanka are analyzed, including the role of the IMF and the World Bank, which took a hard line on spending cuts during the pandemic. The reasons for the ineffectiveness of measures to reduce the budget deficit and the public sector in the context of the priority of paying off external debt are clarified. In addition, the article highlights the interests and driving forces of the processes associated with the US stock market, operations in which are planting time bombs that can be activated at any moment and lead to perhaps the worst economic recession in modern history.
Features of kaluga sturgeon Acipenser dauricus and amur stergeon Acipenser schrenckii juvenile feeding in the Lower Amur
Authors:   Russian Federal Research Institute of Fisheries and Oceanography (VNIRO), Russia, Moscow, Vilkova O.Yu. , Kolobov V.Yu. ,   Khabarovsk branch of VNIRO, Russia, Khabarovsk, Koshelev V.N. ,   Khabarovsk branch of VNIRO, Russia, Khabarovsk
Published: August 2022

The aim of the work is to study the specifics and nutritional spectrum of juvenile kaluga and Amur sturgeon in the Amur on the halfway from the sturgeon hatcheries to the main feeding place — the Amur Estuary. There was Mysidacea in the food spectrum of juvenile kaluga from the Lower Amur, in 350–390 km from the mouth, in the first decade of July 2021. Mysids were found in 70% of the studied gastrointestinal tracts and their mass fraction was almost 44%. Fish played a secondary role in the diet of kaluga. The diet of the Amur sturgeon consisted mainly of Trichoptera (83.33%) and Chironomidae (42%) larvae. Mollusks were not found in the gastrointestinal tract of juveniles of both species feeding in the Amur riverbed. Both in diversity and the index of filling the gastrointestinal tracts, the diet of sturgeons in the Amur at the beginning of July 2021 was significantly inferior to the diet described by previous studies. The average number of identified objects in the gastrointestinal tracts of kaluga and sturgeon was 1.2 and 1.4, respectively; average gastric filling index — 41.1 and 28.8; the average value of the fatness coefficient for kaluga was 0.62, for sturgeon — 0.51. The different type of feeding and the range of food objects show that kaluga and Amur sturgeon juveniles are not food competitors in this section of the Amur. The high content of sand in the stomachs of sturgeons, 2.5 times higher by weight than the mass of the food in bolus, indicates the poverty of the sturgeon feed base on this section of the river in the conditions of abnormal flooding of the spring-summer season of 2021. In such hydrological conditions, food organisms — small fish, insect larvae — dispersed over large areas of the river floodplain, that made them hard-to-get for sturgeons living in the main channel and permanent channels.
In Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter
Authors: Wu Aihua , Wolley Martin J. , Matthews Alexandra , Cowley Diane , Welling Paul A. , Fenton Robert A. , Stowasser Michael
Published: August 2022

Key Points

Potassium chloride intake induced a reduction in sodium-chloride cotransporter (NCC) and phosphorylated NCC in urinary extracellular vesicles from patients with primary aldosteronism during a significantly raised level of endogenous aldosterone.

Low plasma potassium (secondary to aldosterone excess) may dominate in terms of NCC regulation in the setting of primary aldosteronism.

Background

Elevated abundance of sodium-chloride cotransporter (NCC) and phosphorylated NCC (pNCC) are potential markers of primary aldosteronism (PA), but these effects may be driven by hypokalemia.

Methods

We measured plasma potassium in patients with PA. If potassium was <4.0 mmol/L, patients were given sufficient oral potassium chloride (KCl) over 24 hours to achieve as close to 4.0 mmol/L as possible. Clinical chemistries were assessed, and urinary extracellular vesicles (uEVs) were examined to investigate effects on NCC.

Results

Among 21 patients with PA who received a median total dose of 6.0 g (2.4–16.8 g) of KCl, increases were observed in plasma potassium (from 3.4 to 4.0 mmol/L; P<0.001), aldosterone (from 305 to 558 pmol/L; P=0.01), and renin (from 1.2 to 2.5 mIU/L; P<0.001), whereas decreases were detected in uEV levels of NCC (median fold change(post/basal) [FC]=0.71 [0.09–1.99]; P=0.02), pT60-NCC (FC=0.84 [0.06–1.66]; P=0.05), and pT55/60-NCC (FC=0.67 [0.08–2.42]; P=0.02). By contrast, in 10 patients with PA who did not receive KCl, there were no apparent changes in plasma potassium, NCC abundance, and phosphorylation status, but increases were observed in plasma aldosterone (from 178 to 418 pmol/L; P=0.006) and renin (from 2.0 to 3.0 mU/L; P=0.009). Plasma potassium correlated inversely with uEV levels of NCC (R
2=0.11; P=0.01), pT60-NCC (R
2=0.11; P=0.01), and pT55/60-NCC (R
2=0.11; P=0.01).

Conclusions

Acute oral KCl loading replenished plasma potassium in patients with PA and suppressed NCC abundance and phosphorylation, despite a significant rise in plasma aldosterone. This supports the view that potassium supplementation in humans with PA overrides the aldosterone stimulatory effect on NCC. The increased plasma aldosterone in patients with PA without KCl supplementation may be due to aldosterone response to posture challenge.
Network Analysis on Graves' Ophthalmopathy
Authors: AYDIN Bünyamin , KÖYLÜOĞLU Ayşe Nilüfer
Published: August 2022

Introduction: Graves' ophthalmopathy (GO), sometimes known as Graves' orbitopathy, is an eye illness that can lead to vision loss. Despite significant developments in ophthalmology over the previous few decades, there is no comprehensive bibliometric description of the quality and quantity of GO research in the peer-reviewed literature. The purpose of this study was to examine the trends in GO publications. Materials-Methods: The bibliometric search was conducted using the Web of Science (WoS) Core Collection advanced search engine. Keywords related to “Graves” and “ophtalmopathy” or “orbitopathy” were used. The time span was set from 1970 to 2021. The researchers looked at data on publishing growth, the most active countries and institutions, the most cited journals, and publishing and keyword mapping. The articles were investigated thoroughly. The maps were visualized using the VOSviewer technique. Results: The Wos database yielded 958 articles about GO. These 958 articles had an average of 29.59 citations each. These items have a H index of 81. The majority of the papers found were in the fields of endocrinology and metabolism (38.83 percent), followed by ophthalmology (25.99 percent), with the United States as the leading country. The articles garnered a total of 28348 citations, averaging 29.59 per article. Annual citation growth of GO was sluggish until the 1990s, then skyrocketed in the subsequent decade. Conclusion: The USA was the leading country but the rest of the world made a significant contribution. The quantity of citations is great, yet global collaboration is required to address this increasing and worrisome issue.
Maymun Çiçeği Virüsüne Karşı Antiviral Yaklaşım ve Bağışıklık
Authors: KERGET Ferhan , PARLAK Emine
Published: August 2022

İnsan maymun çiçeği, çift sarmallı DNA (dsDNA) virüslerinin Poxviridae ailesindeki Orthopoxvirus cinsinin bir üyesi olan maymun çiçeği virüsünün neden olduğu zoonotik bir enfeksiyondur. İlk olarak 1970 yılında Demokratik Kongo Cumhuriyeti'nde dokuz aylık bir bebekte tanımlandı. O zamandan beri, Orta ve Batı Afrika'da ve bazen Avrupa ve Kuzey Amerika'da beş salgınla sonuçlandı. Endemik bölgelerdeki insan enfeksiyonları, enfekte hayvanlarla avlanma ve deri yüzme yoluyla yakın temas veya evde kemirgen istilası ile ilişkili olarak tanımlanmıştır. İnsandan insana bulaşma, özellikle çiçek hastalığına karşı aşılanmamış olanlar arasında, indeks vakaların ev temaslılarında da tanımlanmıştır. Bulaşma yolları, tükürük, solunum salgıları, cilt lezyonları, vücut sıvıları veya kontamine cisimlerle temasdır. Çiçek hastalığının eradikasyonundan ve rutin çiçek aşısından sonra Maymun çiçeği hastalığına karşı duyarlı konaklarda artış izlenmiştir. Çiçek aşısının maymun hastalığına karşı %85 koruma sağladığı tahmin edilmektedir.
Maymun çiçeği virüsü hastalığı (MÇVH) hastaların çoğunda medikal tedavi ile birlikte iyileşmektedir. Semptomları hafifletmek, komplikasyonları azaltmak için klinik bakım ve destekleyici tedavi verilmelidir. Kusma, ishal gibi sıvı kayıplarının olduğu gastrointestinal semptomları olan hastalara oral ya da intravenöz sıvı tedavisi gerekmektedir. Sekonder bakteriyel enfeksiyon izlendiği durumlarda etkene özgü ve uygun antibiyotik tedavisi verilmelidir. Atipik bölgelerdeki (örneğin ağız, gözler, genital bölge) maymun çiçeği enfeksiyonu için tedavi de düşünülebilir.
Bir takım ilaçlar denenmiştir ama etkinliği net değildir. Etkinliği olabileceği düşünülen antiviraller; Tecovirimat (TCV), brincidofovir (BCV) ve cidofovir (CDV)’ dir. Bazı uzmanlar şiddetli hastalığı olan hastalarda TCV ve CDV ile ikili tedavi önerebilse de, şu anda TCV tercih edilen tedavidir.
MÇVH riskini azaltabilecek iki mevcut aşı vardır. Yüksek risk maruziyeti olan bireylere temas sonrası 14 gün içinde aşılama önerilir. Maruziyet sonrası aşılama, düşük risk maruziyeti olanlar için endike değildir.
Avaliação de práticas de gestão do conhecimento no Exército Brasileiro: um estudo de caso no complexo militar do Pinheirinho
Authors: Rossetto Carlos Ricardo , Sales Pablo Damasceno
Published: August 2022

As dificuldades surgidas devido ao aumento da velocidade das informações no mundo moderno são algo a ser manejado em qualquer instituição da atualidade que esteja preocupada com seu sucesso, seja no setor privado ou no público. A Gestão do Conhecimento (GC) e suas práticas podem auxiliar nesta jornada, facilitando a economia de recursos nos setores mais diversos. O Exército Brasileiro (EB), enquanto instituição nacional permanente, tem características únicas que também o fazem demandar da GC no seu dia-a-dia. Neste trabalho, foi realizada uma análise das práticas de GC em um grupo de unidades do Exército Brasileiro, baseada no trabalho de Batista e Quandt (2015), verificando-se os aspectos “estágio de implantação” e “alcance”. As práticas abordadas foram divididas conforme as dimensões da GC propostas por Misra (2007), a saber: gestão de recursos humanos (Pessoas), processos organizacionais (Processos) e base tecnológica e funcional (Tecnologia). O instrumento de pesquisa foi respondido por 207 pessoas, com escolaridade mínima de ensino médio completo, participantes de todas as Organizações Militares (OM) do complexo militar do bairro Pinheirinho, na cidade de Curitiba, Paraná. A pesquisa caracterizou-se como “exploratória-descritiva”, na modalidade “estudo de caso” e subtipo “estudo de casos múltiplos”, com viés quantitativo. O trabalho realizado pode ser aplicado em outras OM, instituições públicas, empresas privadas ou mesmo em partes destes estabelecimentos, a fim de se diagnosticar a Gestão do Conhecimento, de se proporem medidas de aprimoramento de suas práticas e, por consequência, melhorar a eficiência funcional dos locais analisados.
Achieving Academic Satisfaction through the use of Education-Based Technologies: Strengthening Students Personal Well-being While Facing Online Learning Mandates and Digital Disparities
Authors: Pearce Angela
Published: August 2022

In early 2020, 1.6 billion students were forced to engage in remote learning for the purposes of education continuation. As a result of online learning mandates, digitized and mobile technologies have influenced various dimensions of students’ personal well-being. Many students are subjected to the digital inclusion of having the needed technologies to effectively engage in electronic-based learning platforms and infrastructures. Contrary to such, various student bodies face pandemic and pre-pandemic digital disparities and social exclusions, thus denying them the opportunity to participate in electronic-based educational practices required for academic achievement and success. This study explores how educational-based technologies are used to increase students' personal well-being and academic satisfaction while also facing online learning mandates and being subjected to digital disparities. Moreover, this study evaluates how multifactorial and innovative technologies for educational practices impede or proliferate well being, life and academic satisfaction, and happiness. Seligman’s (2011) PERMA Theory of Well-being is adopted as a grounding method. The PERMA Theory of Well-being comprises five distinct pillars: positive emotions, engagements, relationships, meaning, and achievement. These distinguished dimensions are significant to commissioning educational-based types of machinery and platforms for the purposes of knowledge acquisition and intellectual sustainability. In a broader sense, the digital gap persists between communities, generations, and geographically. Being provided or being able to afford the necessary physical materials and resources is vital when propagating the idea of taking an online/remote/blended learning approach. Implications and future suggestions are addressed and discussed.
The circular pond of Dehbarm in the Firuzabad Plain (Fars, Iran)
Authors: RASHIDIAN Elnaz , ASKARI CHAVERDI Alireaza
Published: August 2022

We present the preliminary results of our recent find, a circular pond, and its surrounding structures, built in stone masonry of Sasanian tradition in the Dehbarm village, west Firuzabad Plain (Fars, Iran). We elaborate on this site and suggest it belongs to the Early Sasanian Ardashir-Xurra (Ardašīr-Xwarrah), the first Sasanian capital and complex urban plan of the Firuzabad plain. Based on comparable finds, we interpret Dehbarm as a garden settlement, a so-called paradise, and consider it a case study for water management and landscape manipulation of the Late Antiquity in the Greater Fars. Additionally, we ponder on the broader aspect of spring-fed ponds in the Sasanian architectural tradition. Further investigation, as well as extensive fieldwork, is planned to address this aspect.
Improvement of the red wines quality by using yeast derivatives as an alternative to lees aging
Authors: Iosip (Dragomir) Elena , Bahrim Gabriela Elena , Stănciuc Nicoleta , Constantin Oana Emilia , Croitoru Constantin , Râpeanu Gabriela
Published: August 2022

The macromolecules originating from yeast play an essential function in the colloidal equilibrium of wines. For several years now, mannoproteins from alcoholic fermentation and yeast autolysis have been studied to improve tartaric balance and stabilize red wine color and phenolic compounds. Thus, a commercial yeast derivatives product was applied (30 g/hL) during maceration, compared with the traditional wines aging on the lees, to evaluate the influence of treatment during alcoholic fermentation on wine's chromatic and sensory characteristics after 3 and 6 months of aging. The yeast derivatives product enhanced the structure and volume of red wines during maturation and reduced the feeling of dryness, attenuating tannins with aggressive structure. The addition of yeast derivatives enriched the red wine in colloids and nitrogen compounds (amino acids, peptides, low molecular weight proteins) during the fermentation, significantly improving the sensory profile and protein stability. From a sensorial point of view, the wine treated with yeast derivatives was more equilibrated, having expressive characteristics such as roundness and fullness. Overall compared to traditional aging on lees, the commercial treatment was more stable, eliminating the risk of unwanted sensory deviations such as hydrogen sulfide odors.
Tunisian Opuntia ficus-indica fruit peels: biochemical and microbiological characterization and possible applications
Authors: Bouazizi Souhir , Montevecchi Giuseppe , Masino Francesca , Antonelli Andrea , Hamdi Moktar
Published: August 2022

In Tunisia, the number of prickly pear seed oil companies is currently increasing. However, a large amount of prickly pear fruit by-products is discarded. Proper utilization of these by-products, in particular fruit peels, could lead to the obtaining of a new important source of nutraceutical compounds. This investigation was aimed at conducting a phytochemical screening and assessing the antibacterial properties of prickly pear peels cultivar ‘orange’. These samples were analyzed fresh and oven-dried at 45 °C to develop concepts for applications in the food industry as potential sources of fibers and antimicrobial “green” additives. The proximate compositions of both prickly pear peels were determined along with total phenolic compounds, carotenoids, and antioxidant activity. Free phenolic compounds were determined using liquid chromatography coupled with mass spectrometry. Furthermore, the antibacterial effectiveness of the prickly pear peel extracts was tested against selected foodborne pathogens. The highest concentrations of dietary fiber (22.7 g/100 g d.m.) and carotenoids 10.90 mg/100 g d.m. were observed in oven-dried prickly pear peels, which also showed the highest inhibition of the DPPH radicals. The antibacterial activities showed a relevant growth inhibition against Bacillus cereus and a partial inhibition against Staphylococcus aureus. Prickly pear peel is a neglected nutritional and antibacterial source that should be widely valued as food additive.
Morin (2′,3,4′,5,7-Pentahydroxyflavon) Antioxidant Effect in Streptozotocin-Induced Diabetic Rat Brain and Heart Tissues
Authors: BEYATLİ Ahmet , GÜLEÇ PEKER Emine Gülçeri , GÜL Nursel , CEVHER Şule Coşkun
Published: August 2022

Diabetes mellitus is agreed to be among the biggest public health burdens seen at the world. Recently, the using natural products (flavonoids specially) in diabetes treatment witnessed a growing interest due to insulin's and oral anti-diabetic medicines' unfavorable side effects. The present work is studies the beneficial effects of morin (2′,3,4′,5,7-pentahydroxyflavone) on antioxidant of tissues and lipid peroxidation status in diabetic and non-diabetic rats. Diabetes associated with elevation in reactive oxygen species and deficient in antioxidant activity, which is important aspects for pathogenesis of diabetes. The role of morin on the brain and heart antioxidant markers were estimated. The diabetic rats exhibited elevated levels of TBARS, NOx and GSH levels in brain and heart tissues when compared with healthy animals. The treatments using morin significantly stopped elevation in brain and heart TBARS and NOx levels. Oral administration of morin showed significant increase in GSH level in brain tissue. These results indicated that morin exerts antioxidative activity in diabetic rats.
The Effect Of Exclusive Breastfeeding Education Through Telehealth With The Sociodrama Method Towards Knowledge Of Post Partum Mother
Authors: Siti Nur Endah Hendayani  , Siti Nur Azizah  , Rika Nur Hasanah
Published: August 2022

Breast milk is the primary source of nutrition for newborns and toodler, containing fat, protein, carbohydrates and variable minerals and vitamins. Breast milk also contains substances that help protect an infant against infection and inflammation, whilst also contributing to healthy development of the immune system and gut microbiome.  Effort for increase exclusive breastfeeding  among mother is  increase of mother knowledge through education. Utilization of the sociodrama method  in education will make it easy delivery message to mother. The aim of this study is to identified the effect of exclusive breastfeeding education through telehealth with the sociodrama method towards knowledge of post partum mother. This study uses a quasi-experimental design with one group pretest-posttest. The population in this study were postpartum mothers, sampling was taken a total sampling of 31 postpartum mothers who were in the working area of ​​the Cibeber Health Community Center at Cimahi City. The primary data collection technique used was a questionnaire with a sociodrama video intervention. Data analyzed by  paired t test non parametic wilcoxon at a significant level of 5%. The conclusion of this study shows that there is an effect of providing exclusive breastfeeding education through telehealth with the sociodrama method on mother's knowledge. The recommendation based on the results of this study is that health workers use the sociodrama method as an alternative media in providing education to breastfeeding mothers
COMPARISON OF TWO DIFFERENT MODALITIES OF BICARBONATE FOR DETERMINATION OF ANION GAP IN CRITICALLY ILL PATIENTS
Authors: Orakzai Sheryar , Hussain Munir , Ijaz Aamir , Sadiq Sidra , Dawood Mirza Muhammad , Zeb Jehan
Published: August 2022

OBJECTIVE: To compare anion gap estimated through measured and calculated bicarbonate modalities to be used interchangeably in critically ill metabolic acidosis patients. METHODS: This cross-sectional study was conducted at Rehman Medical Institute, Peshawar, Pakistan from September 2019 to March 2020.  Out of 390 critically ill patients, 200 cases of metabolic acidosis were selected by non-probability consecutive sampling technique. Measured and calculated bicarbonate values were obtained through Cobas-c 501© (Roche) using enzymatic method and Cobas-b 221© (Roche) blood gas analyzer respectively. Statistical analysis was done by using SPSS-23. RESULTS: Normal anion gap metabolic acidosis (NAG-MA) and high anion gap metabolic acidosis (HAG-MA) based on calculated bicarbonate levels was observed in 57 (28.5%) and 143 (71.5%) cases as compared to 55 (27.5%) and 145 (72.5%) cases based on measured bicarbonate levels respectively (p>0.45). A significant correlation (r=0.888 and 0.656, r2=0.788 and 0.431) (p<.001) was found between mean values of NAG-MA and HAG-MA respectively, when each was calculated through both modalities of bicarbonate. On applying Bland Altman plot, bias was 1.45±2.89 and -2.14±3.87mmol/L, Upper limit of agreement (LOA) was 7.13 and 5.46 for NAG-MA and HAG-MA, while lower LOA was -4.23 and -9.74 for NAG-MA and HAG-MA respectively. According to the model Bland Altman plot and Story & Postuie criteria, bias and the levels of agreement were not appropriate to conclude that both entities of anion gap could be used interchangeably.  CONCLUSION: Normal and high anion gap metabolic acidosis estimated by measured and calculated bicarbonate cannot be used interchangeably in critically ill patients.
ASSOCIATION BETWEEN ANGULATION OF MANDIBULAR THIRD MOLAR IMPACTIONS WITH FACIAL SKELETAL TYPES AND CEPHALOMETRIC LANDMARKS
Authors: Afridi Sonia Umar , Baseer Najma , Durrani Zubair , Afridi Muhammad Ibrahim , Jehan Shahida
Published: August 2022

OBJECTIVE: To determine the association of impacted mandibular third molar with skeletal facial types and different anatomical and cephalometric landmarks. METHODS: This cross-sectional study was conducted at Rehman College of Dentistry and Khyber College of Dentistry, Peshawar, Pakistan from October to December 2020. Panoramic and lateral cephalometric radiographs of 800 patients (aged 22-35 years) were retrieved from the records. Third molar impaction was classified by Winter’s classification using IC Measure software. The skeletal facial type was determined by measuring Point A Nasion Point B angle using Viewbox software. An association of third molar impaction with skeletal facial types, cephalometric and anatomical variables was evaluated. RESULTS: The most common mandibular tooth impactions type was Mesioangular impaction (81.3%) and skeletal facial type was skeletal class-I (47.5%). Comparative analysis among different impaction types using One-way ANOVA showed that although these impaction types did not differ significantly in terms of skeletal facies (p=0.07), significant difference in terms of age (p=0.028), Maxillary Mandibular Plane Angle (MMPA) (p=0.007), depth (p=0.000), ramus relation (p=0.000) and inferior dental nerve (ID) canal (p=0.001) were observed. ID canal was found to be positively but weakly correlated (r=0.2) with impaction types. Contrariwise, depth and ramus relation showed moderately negative correlation (r=-0.40 and r=-0.30, respectively) with impacted tooth angulations. CONCLUSION: Although it is difficult to predict the impaction type in patient based on their skeletal facies, associations between other anatomical and cephalometric variables were observed which may help in predicting the degree of difficulty that may be encountered during the surgical procedures.