bluuebunny/crossref_metadata_2025 huggingface dataset:
agroecossistemas tradicionais e sua influência na paisagem da caatinga
Authors: Silva dos Santos Joelma , Antunes de Carvalho Aurélio José
Published: July 2022

O presente trabalho tem como objetivo evidenciar como as transformações na paisagem da caatinga, decorrentes dos agroecossistemas, ao longo das últimas cinco décadas, são percebidas pelos(as) moradores(as) da comunidade Água Branca de Fora no município baiano de Saúde. Foram realizadas pesquisas bibliográficas e de campo, inicialmente a fim de explicitar os conceitos de agroecossistemas e paisagem geográfica, fundamentados nas contribuições teóricas de estudos das ciências agrárias e geográfica. Os instrumentos de pesquisa utilizados em campo foram entrevistas semiestruturadas e mapas mentais. A análise de conteúdo foi usada para categorizar e descrever a realidade percebida, tal como ela é. Dentre os diversos fatores percebidos, destacaram-se: as atividades agropecuárias, as cercas, a criação de pastagens e o crescimento das famílias. Concomitantemente uma preocupação ambiental emerge nos(as) moradores(as) ao perceber questões até então abstrusas que, posteriormente, poderão reverberar em mudanças de atitudes, sobretudo no que tange o uso e o manejo racional da caatinga e dos agroecossistemas do Semiárido.
Cutaneous T-Cell–Rich Lymphoid Infiltrates After SARS-CoV-2 Vaccination
Authors: Hooper Madeline J. , Veon Francesca L. , LeWitt Tessa M. , Chung Christopher , Choi Jaehyuk , Zhou Xiaolong A. , Guitart Joan
Published: July 2022

This case series study describes cutaneous T-cell–rich lymphoid infiltrates characterized by papulonodules on the trunk and/or extremities in 6 patients after receiving the Pfizer/BioNTech COVID-19 mRNA vaccine.
Is a weekly qualitative picket fence test sufficient? A proposed alternate EPID‐based weekly MLC QA program
Authors: Kalavagunta Chaitanya , Xu Huijun , Zhang Baoshe , Mossahebi Sina , MacFarlane Michael , Jiang Kai , Lee Sung‐Woo , Chen Shifeng , Sawant Amit , Gopal Arun , Yi ByongYong
Published: July 2022

Purpose

Well‐designed routine multileaf collimator (MLC) quality assurance (QA) is important to assure external‐beam radiation treatment delivery accuracy. This study evaluates the clinical necessity of a comprehensive weekly (C‐Weekly) MLC QA program compared to the American Association of Physics in Medicinerecommended weekly picket fence test (PF‐Weekly), based on our seven‐year experience with weekly MLC QA.

Methods

The C‐Weekly MLC QA program used in this study includes 5 tests to analyze: (1) absolute MLC leaf position; (2) interdigitation MLC leaf position; (3) picket fence MLC leaf positions at static gantry angle; (4) minimum leaf‐gap setting; and (5) volumetric‐modulated arc therapy delivery. A total of 20,226 QA images from 16,855 tests (3,371 tests × 5) for 11 linacs at 5 photon clinical sites from May 2014 to June 2021 were analyzed. Failure mode and effects analysis was performed with 5 failure modes related to the 5 tests. For each failure mode, a risk probability number (RPN) was calculated for a C‐Weekly and a PF‐Weekly MLC QA program. The probability of occurrence was evaluated from statistical analyses of the C‐Weekly MLC QA.

Results

The total number of failures for these 16,855 tests was 143 (0.9%): 39 (27.3%) for absolute MLC leaf position, 13 (9.1%) for interdigitation position, 9 (6.3%) for static gantry picket fence, 2 (1.4%) for minimum leaf‐gap setting, and 80 (55.9%) for VMAT delivery. RPN scores for PF‐Weekly MLC QA ranged from 60 to 192 and from 48 to 96 for C‐Weekly MLC QA.

Conclusion

RPNs for the 5 failure modes of MLC QA tests were quantitatively determined and analyzed. A comprehensive weekly MLC QA is imperative to lower the RPNs of the 5 failure modes to the desired level (<125); those from the PF‐Weekly MLC QA program were found to be higher (>125). This supports the clinical necessity for comprehensive weekly MLC QA.
Ion‐Implantation in Titania‐Based Plasmonic Photo‐anodes: A Review
Authors: Vemula Sai Krishna , Raavi Sai Santosh Kumar
Published: July 2022

The metal‐oxide semiconductors exhibit remarkable optoelectronic properties and have immense implication in applications involving energy conversion, light emission, environmental remediation, etc. The presence of metal nanostructures in titanium dioxide (TiO2), zinc oxide metal‐oxide semiconductors have enhanced the photo‐activity, due to the plasmon resonances and are predominantly researched for organic and perovskite photovoltaics. Generally, the metal nanoparticle dopants are introduced by methods like sputtering, sol–gel, etc. However, compared with conventional doping methods, ion‐implantation technique is a purely physical process, and a high controllability and repeatability can be achieved. Here, the current status of synthesis of nanocomposites in TiO2‐based photo‐anodic applications by ion‐implantation method is reviewed, and there is no elaborate review on this topic. Finally, the future prospects of ion‐implantation technique for controlling the excitonic behavior in TiO2 are discussed.
Resilient iterative learning control for a class of discrete‐time nonlinear systems under hybrid attacks
Authors: Zhao Xuyang , Yin Yanling , Bu Xuhui
Published: July 2022

The security control problem for a class of unknown nonlinear systems is considered in this paper. For the nonlinear system running in the network environment, the measurement channel is subjected to hybrid attacks. Intermittent denial of service attacks and false data injection attacks are modeled as the hybrid attacks. According to the characteristics of the repetitive system, a resilient iterative learning control (ILC) algorithm under hybrid attacks is devised. Subsequently, the stability of the system is proved by mathematical derivation and theoretical analysis in the sense of mathematical expectation. The theoretical analysis results indicate that the resilient ILC algorithm can ensure the stability of the system, and the tracking error converges with the increased number of iterations. Finally, the validity of the algorithm is illustrated by numerical simulation and mobile robot simulation.
Model predictive control‐based longitudinal control for autonomous electric vehicle with changing mass
Authors: Wang Yijing , Deng Yuxiang , Wang Haoyu , Zuo Zhiqiang
Published: July 2022

In this paper, a longitudinal control strategy in terms of model predictive control (MPC) and mass estimator is investigated for an autonomous electric vehicle (AEV). A driving force table (DFT) is established to represent the relationship among throttle opening, speed, and driving force. A mass estimator is designed to obtain the actual mass of AEV. An MPC‐based controller with constraints is suggested to get the desired acceleration. Moreover, a feedforward controller is developed to calculate the throttle opening directly. Both the iterative feasibility and stability of the MPC are ensured. The experimental results are given to show the effectiveness of our strategy with mass estimator.
Autistic people outperform neurotypicals in a cartoon version of the Reading the Mind in the Eyes
Authors: Cross Liam , Piovesan Andrea , Atherton Gray
Published: July 2022

Prior research suggests that while autistic people may demonstrate poorer facial emotion recognition when stimuli are human, these differences lessen when stimuli are anthropomorphic. To investigate this further, this work explores emotion recognition in autistic and neurotypical adults (n = 196). Groups were compared on a standard and a cartoon version of the Reading the Mind in the Eyes test. Results indicated that autistic individuals were not significantly different from neurotypicals on the standard version. However, autistic people outperformed neurotypicals on the cartoon version. The implications for these findings regarding emotion recognition deficits and the social motivation account of autism are discussed and support the view of socio‐cognitive differences rather than deficits in this population.

Lay Summary

The Reading the Mind in the Eyes test and a cartoon version were tested on autistic and neurotypical adults. Autistic adults were not significantly different on the original test compared to neurotypicals, but they outperformed neurotypical adults on the cartoon version.
The meanings, risk factors and consequences of religious extremism: The perceptions of Islamic education teachers from Israel
Authors: Saada Najwan
Published: July 2022

This multiple case study examines the attitudes of 14 Islamic education teachers from Israel towards the meaning, causes and consequences of religious extremism among students in their Arab and Muslim‐majority middle and high schools. These teachers define religious extremism as belief in absolute religious truth, inflexibility in religious interpretation, or strict adherence to Islamic teachings. In addition, the teachers distinguish the personal (adolescence, family problems and psychosocial needs), religious (unquestioned following of extremist imams or religion scholars; adopting of selective, literal and decontextualised readings of the religious text; influence of partisan teachers) and socio‐political factors (students' feelings of fear and anger towards Israel and its unjust and oppressive role in the Palestinian–Israeli conflict) that push students towards religious extremism. Religious extremism, the teachers conclude, may lead to hatred or violence against followers of other religions, antagonism between Muslims and Jews in Israel, increased Islamophobia in Western societies, the rejection of Islam, the oppression of female students and reduced student achievement and diminished future prospects.
The effect of compatibility of Aconiti Radix and honey on the pharmacokinetics of five Aconitum alkaloids in rat plasma
Authors: Wu Jiaofeng , Duan Rong , Deng Haoran , Li Lele , Zhao Yunli , Yu Zhiguo
Published: July 2022

Aconiti Radix [Chuanwu (CW)] is widely used to treat chronic and intractable diseases due to its remarkable curative effect. CW has been combined with honey for thousands of years to reduce toxicity and enhance efficacy. This study first determined the compatibility mechanism of CW with honey using a comparative pharmacokinetic concept. We developed and validated a simple, sensitive, specific, and accurate UHPLC–MS/MS method to simultaneously determine five Aconitum alkaloids in rat plasma after the oral administration of CW decoction and CW–honey concentrated solution. Pharmacokinetic parameters were significantly different between the two groups (P < 0.01 and P < 0.05). Compared with the CW group, Cmax and AUC0 → t decreased in the CW–honey group for three diester‐diterpenoid alkaloids (hypaconitine, mesaconitine, and aconitine); Tmax and T1/2 were prolonged. However, Cmax and AUC0 → t increased in the CW–honey group for two monoester‐diterpenoid alkaloids (benzoylaconine and benzoylmesaconine); Tmax was shortened, and T1/2 was prolonged. These findings suggest that honey affected the pharmacokinetic behaviors of five Aconitum alkaloids. We speculate that the detoxification and synergism of honey might result from reducing the toxicity of diester‐diterpenoid alkaloids and promoting the biological activity of monoester‐diterpenoid alkaloids in vivo. This study provides a theoretical basis for the clinical use of CW combined with honey.
Green innovation and enterprise reputation value
Authors: Chen Zhongfei , Hao Xinyue , Chen Fanglin
Published: July 2022

Using the data of Chinese listed enterprises in 2007–2020, we investigate the relationship between green innovation (GI) and enterprise reputation via OLS regression, IV‐Lasso, and random forest. Findings show that GI can improve enterprise reputation, and it has a significant positive lag effect. Additionally, we compare the different effects of green patent applications and approved green patents. A possible mechanism is that GI reduces the pollution emission of enterprises. GI also performs better in improving the reputation of coastal enterprises, state‐owned enterprises and large‐scale enterprises, and old enterprises. Our finding on the causal relationship between GI and enterprise reputation is of great significance in further understanding the practical value of GI activities, and it has certain reference value for the policy formulation of governments and decision making of enterprises.
Localization of the nerves innervating the pelvic floor muscles: An application to pelvic pain treatment
Authors: Hu Xiangnan , Hu Shuangjiang , Wang Meng , Xiong Wei , Yang Shengbo
Published: July 2022

The aim of this study was to achieve accurate localization of the body surface position and depth of the center of the intramuscular nerve dense region (CINDR) of the pelvic floor muscles and to establish a target site for treating pelvic floor muscle spasm or weakness. Thirty‐six adult cadavers were studied in the prone position. To locate the CINDR of the levator ani and coccygeus muscles, horizontal (H) and longitudinal (L) reference lines were used. Sihler's staining revealed the intramuscular nerve dense region of the pelvic floor muscles. The CINDR was labeled with barium sulfate and spiral computed tomography scanning, and three‐dimensional reconstructions were obtained. The anterior and posterior CINDR projection points (P and P′), the position of point P projected on to the H and L lines (PH and PL), and the CINDR depth were determined using the Syngo system. The PH of the CINDR of the levator ani and the coccygeus muscle were located at (24.73 ± 0.17)% and (15.93 ± 0.31)% of the H line, respectively. The PL were located at (84.30 ± 2.47)% and (6.76 ± 0.93)% of the L line. The puncture depth of the levator ani muscle was located at (5.56 ± 0.53) cm, and the depth of the coccygeus muscle at (22.08 ± 2.11)% of the PP' line. The body surface position and depth of the CINDR of the pelvic floor muscles were conducive to locating the target more efficiently and enhancing the efficacy of botulinum toxin A injection for treating pelvic floor muscle spasm and weakness with electrical stimulation or biofeedback.
ANKHD1 contributes to the malignant phenotype of triple‐negative breast cancer cells
Authors: de Almeida Bruna O. , de Almeida Larissa C. , Costa‐Lotufo Leticia V. , Machado‐Neto João A.
Published: July 2022

Ankyrin repeat and KH domain‐containing protein 1, ANKHD1, has been identified as a regulator of signaling pathways and cellular processes of relevance in carcinogenesis. However, the role of ANKHD1 in breast cancer remains unclear. The aim of the present study was to characterize the expression pattern and involvement of ANKHD1 in the malignant phenotype of breast cancer cell lines and to investigate the clinical relevance of ANKHD1 in a breast cancer context. Gene and protein expressions were assessed in the cell lines by quantitative reverse transcription PCR and Western blot analysis, respectively, and ANKHD1 silencing through siRNA transfection was conducted for further in vitro functional assays. The expression of ANKHD1 was identified in non‐tumorigenic breast epithelium and breast cancer cell lines, but differences in cellular localization were found among the neoplasia subtypes. ANKHD1 silencing reduced the viability, clonogenicity, and migration of triple‐negative breast cancer (TNBC) cells. Bioinformatics analyses demonstrated that patients with triple‐negative basal‐like 2 and mesenchymal breast cancer subtypes had high ANKHD1 expression associated with poor recurrence‐free survival. Therefore, these data indicate that ANKHD1 relevance in breast cancer varies among its subtypes, indicating the importance of ANKHD1 in TNBC.
LMCD1 facilitates the induction of pluripotency via cell proliferation, metabolism, and epithelial‐mesenchymal transition
Authors: Ye Zhikai , Chen Ge , Hou Cuicui , Jiang Zhenlong , Wang Erkang , Wang Jin
Published: July 2022

Somatic cell reprogramming was achieved by lentivirus mediated overexpression of four transcription factors called OSKM: OCT3/4, SOX2, KLF4, and c‐MYC but it was not very efficient. Here, we reported that the transcription factor, LMCD1 (LIM and cysteine rich domains 1) together with OSKM can induce reprogramming of human dermal fibroblasts into induced pluripotent stem cells (iPSCs) more efficiently than OSKM alone. At the same time, the number of iPSCs clones were reduced when we knocked down LMCD1. Further study showed that LMCD1 can enhance the cell proliferation, the glycolytic capability, the epithelial‐mesenchymal transition (EMT), and reduce the epigenetic barrier by upregulating epigenetic factors (EZH2, WDR5, BMI1, and KDM2B) in the early stage of reprogramming, making the cells more accessible to gain pluripotency. Additional research suggested that LMCD1 can not only inhibit the developmental gene GATA6, but also promote multiple signaling pathways, such as AKT and glycolysis, which are closely related to reprogramming efficiency. Therefore, we identified the novel function of the transcription factor LMCD1, which reduces the barriers of the reprogramming from somatic to pluripotent cells in several ways in the early stage of reprogramming.
Evaluation of the incidence of radial artery occlusion using different introducer sheaths and hemostasis techniques
Authors: Patel Purveshkumar , Sethi Nishant , Patel Gaurav A. , Kalisetti Deepika , Patel Tejas M.
Published: July 2022

Background

Radial artery occlusion (RAO) remains one of the most important complications of transradial access (TRA). Despite the identification of multiple predictors, the interaction between these predictors on the occurrence of RAO has not been evaluated.

Methods

Consecutive patients undergoing TRA coronary angiography (CA) or percutaneous coronary intervention (PCI), were retrospectively analyzed to compare the effect of standard patent hemostasis using a one‐bladder band versus two‐bladder band with simultaneous ipsilateral ulnar artery compression and two introducer sizes on the primary endpoint of RAO. Access was obtained using 6‐Fr slender introducer sheath or 7‐Fr slender introducer sheath and hemostasis with either a one‐bladder band or a two‐bladder band. The radial artery was evaluated using ultrasound.

Results

Total of 2019 patients undergoing CA or PCI were included in the analysis. In the one‐bladder band group, the incidence of RAO with a 6‐Fr slender introducer sheath was 4.2%. In those receiving hemostasis with a two‐bladder band, RAO occurred in 1% of patients receiving a 6‐Fr slender introducer sheath versus 0.9% in those receiving a 7‐Fr slender introducer sheath (p = 0.68). Larger radial artery diameter, larger body weight, and a two‐bladder hemostasis band with ipsilateral ulnar compression were independently associated with a lower incidence of RAO.

Conclusion

A two‐bladder band with simultaneous ipsilateral ulnar artery compression when used for radial artery hemostasis, is associated with a lower incidence of RAO, and can mitigate the penalty for a larger catheter with reassuring implications for use of a 7‐Fr capable system for complex transradial PCI.
Directional versus orbital atherectomy of femoropopliteal artery lesions: Angiographic and intravascular ultrasound outcomes
Authors: Babaev Anvar , Halista Michael , Bakirova Zulfiya , Avtushka Valeryia , Matsumura Mitsuaki , Maehara Akiko
Published: July 2022

Objectives

The aim of this study was to compare the ability of two different atherectomy modalities, the directional atherectomy system (DAS) and the orbital atherectomy system (OAS), to modify plaque and augment luminal gain as evaluated by angiography and intravascular ultrasound (IVUS) in patients with symptomatic femoro‐popliteal peripheral arterial disease (PAD).

Background

Atherectomy is frequently utilized in the treatment of complex PAD. To date, there are no head‐to‐head comparisons of existing devices and their selection is based mostly on operator preference rather than on supportive data.

Methods

This was a single‐center, prospective, randomized trial designed to assess the impact of DAS in comparison to OAS on atherosclerotic plaque. Pre‐ and postatherectomy lesion characterization was performed by angiography and IVUS. Drug‐coated balloon (DCB) angioplasty was performed after atherectomy with similar analysis repeated.

Results

Sixty patients were randomized to undergo either DAS or OAS. Pretreatment angiographic and IVUS characteristics were similar in the DAS and OAS groups. DAS led to a greater reduction in plaque volume throughout the entire lesion (5.9% vs. 1.1%, p = 0.003). This corresponded to a greater increase in total vessel and lumen volume by IVUS (161.5 mm3 vs. 50.2 mm3, p = 0.001; 178.6 mm3 vs. 47.0 mm3, p = 0.004, respectively), as well as a reduction in angiographic stenosis (40% vs. 70%, p < 0.001). After DCB, 10 patients required stenting for suboptimal results in the OAS group compared with two in the DAS group (p = 0.021).

Conclusions

Compared to OAS, DAS demonstrated a greater plaque volume reduction and luminal gain with significantly fewer stents needed post‐DCB.
One Vanderbilt – Ganzglas‐Aussichtsboxen für New York
Authors: Schmitt Felix , Hilcken Jonas , Zimmermann Stefan
Published: July 2022

In direkter Nachbarschaft zum Grand Central Terminal wurde im Jahr 2020 der neue Wolkenkratzer One Vanderbilt mit einer Höhe von 427 m fertiggestellt. Es ist damit das derzeit vierthöchste Gebäude in New York. Das „SUMMIT One Vanderbilt“ wurde im Herbst 2021 für die Öffentlichkeit eröffnet und bietet neben einem Außendeck zwei in einer Höhe von 305 m aus der Fassade herausragende Ganzglas‐Aussichtsboxen. Um eine größtmögliche Transparenz und einen ungestörten Blick auf Manhattan zu erreichen, wurden zur Befestigung der Gläser strukturelle Verklebungen und spezielle Zapfenverbindungen aus Glas verwendet. Der Artikel beschreibt sowohl die Entwicklung der neuartigen Glasverbindungen, als auch das Design sowie die Fertigung und Montage dieser außergewöhnlichen Konstruktion.

One Vanderbilt – All‐glass observation boxes for New York. In the direct vicinity of Grand Central Terminal, the new skyscraper One Vanderbilt was completed in 2020 with a height of 427 m. It is currently the fourth tallest building in New York. The “SUMMIT One Vanderbilt” was opened to the public in autumn 2021 and, in addition to an outdoor deck, offers two all‐glass observation boxes protruding from the facade at a height of 305 m. To achieve maximum transparency and an unobstructed view over Manhattan, structural bonding and special mortise‐and‐tenon joints of glass were used to secure the glass. This article describes the development of the innovative glass connections, as well as the design, fabrication and installation of this extraordinary structure.
Holz‐Glas‐Deckenelemente | Experimentelle Untersuchungen
Authors: Hochhauser Werner , Holzinger Katharina , Fadai Alireza
Published: July 2022

Im Rahmen des FFG‐Forschungsprojektes (Nr. 875427) „Holz Glas Hybridbau | Berechnungs‐ und Bemessungskonzepte für geklebte, schubsteife Decken‐ und Dachelemente“ wird auf jahrelanger Forschung im Bereich aussteifender Holz‐Glas‐Verbundkonstruktionen (HGV) aufgesetzt. Novum hierbei ist, dass eine kombinierte Scheiben‐ und Plattentragfähigkeit studiert wird. Um die Anwendbarkeit von HGV als Plattenelement zu ermöglichen, müssen Plattenbeanspruchungen über Klötze, nicht über umlaufende Schubverklebungen abgetragen werden. Die daraus resultierende unterbrochene Schub‐verklebung wird anhand experimenteller kleiner und mittelgroßer Proben untersucht und den Ergebnissen numerischer Methoden gegenübergestellt.

Timber‐glass floor elements | Experimental analyses. The FFG research project (No. 875427) “Timber‐glass hybrid composite | calculation and design concepts for glued, shear‐resistant floor and roof elements” builds on years of research in the field of stiffening timber‐glass hybrid composite (TGC). The novelty here is that a combined slab and plate load‐bearing capacity is being studied. To enable the application of HGV as a plate element, plate stresses must be transferred via blocks, not via circumferential shear bonding. The resulting interrupted shear bonding is investigated on the basis of experimental small and medium‐sized specimens and compared with the results of numerical methods. Existing analytical calculation and design concepts for HGV panels are to be extended for combined loading as a roof and floor element.
Neue Produkte mit strukturellen Silikonverklebungen
Authors: Kassnel‐Henneberg Bruno , Hamdan Ali
Published: July 2022

Aufgrund des fehlenden Verständnisses zum Tragverhalten von Silikon unter Zugbeanspruchung bei behinderter Querdehnung dürfen Klebfugen nur mit einem Seitenverhältnis von 1/3 eingesetzt werden. Durch gezielte Forschung am Institut für Statik und Konstruktion der Universität Darmstadt wurde im Rahmen einer Dissertation ein generelles Materialmodell entwickelt. Glas Trösch hat diese Forschungsarbeit mit Prüfkörpern unterstützt. Durch weitere Untersuchungen im Rahmen der bauaufsichtlichen Zulassung „SWISSRAILING FLAT“ wurde gezeigt, dass die Anwendbarkeit des „Nelder‐Drass Materialmodells” für 2K‐Silikone gegeben ist. Mit dem zusätzlich eingeführten Bemessungskonzept ist es Glas Trösch nun möglich, beliebige strukturelle Klebverbindungen zu bemessen.

New products ideas with structural silicone adhesives. Due to the lack of understanding of the load‐bearing behaviour of silicone under tensile stress with constrained transverse strain, adhesive joints may only be used with an aspect ratio of 1/3. Through specific research at the Institute for Statics and Construction at the University of Darmstadt, a general material model was developed within the framework of a dissertation. Glas Trösch supported this research work with test specimens. Further investigations within the framework of the building authority approval “SWISSRAILING FLAT” showed that the applicability of the “Nelder‐Drass material model” for 2k silicones is given. With the additionally introduced design concept, it is now possible for Glas Trösch to design any structural bonded joints.
Nachhaltige Glasarchitektur durch intelligente Kleb‐ und Dichtstofflösungen
Authors: Scherer Christian , Suh Danny
Published: July 2022

Nachhaltigkeit und Energieeffizienz sind weltweit Leitbilder für die Zukunft. Auch im Bauwesen werden diese Themen angesichts des Klimawandels, steigender Energiepreise, knapper werdender Ressourcen und gesetzlicher Vorgaben immer wichtiger. Nachhaltiges Bauen erfordert neben energieeffizienten Gebäudekonzepten den Einsatz von modernen Werkstoffen in Verbindung mit einer ansprechenden architektonischen Umsetzung. Der vorliegende Beitrag demonstriert am Beispiel des in der koreanischen Metropole Seoul errichteten Parnas Towers, wie Kleb‐ und Dichtstofflösungen von H. B. Fuller | Kömmerling zur Zertifizierung nach dem Nachhaltigkeitsstandard LEED beitragen können. Die hohe Effizienz des Gebäudes wird dabei durch ein ausgeklügeltes Energiekonzept und ein abgestimmtes Gebäudemanagementsystem sichergestellt. Einen großen Anteil an diesem Erfolg haben neben den in die Fassade integrierten Photovoltaik‐Anlagen die hochwärme‐gedämmten, rundum laufenden Isolierglaselemente.

Sustainable glass architecture through intelligent adhesive and sealant solutions. Sustainability and energy efficiency are models for the future worldwide. In the construction industry, too, these issues are becoming more and more important in view of climate change, rising energy prices, increasingly scarce resources and legal requirements. In addition to energy‐efficient building concepts, sustainable building requires the use of modern materials in conjunction with an attractive architectural implementation. Using the example of the Parnas Tower built in the Korean metropolis of Seoul, this article demonstrates how adhesive and sealant solutions from H. B. Fuller | Kömmerling can contribute to certification according to the LEED sustainability standard. The high efficiency of the building is ensured by a sophisticated energy concept and a coordinated building management system. In addition to the photovoltaic systems integrated into the facade, the highly thermally insulated, all‐round insulating glass elements play a major role in this success.
Myosin motors on the pathway of viral infections
Authors: Matozo Tais , Kogachi Leticia , de Alencar Bruna Cunha
Published: July 2022

Molecular motors are microscopic machines that use energy from adenosine triphosphate (ATP) hydrolysis to generate movement. While kinesins and dynein are molecular motors associated with microtubule tracks, myosins bind to and move on actin filaments. Mammalian cells express several myosin motors. They power cellular processes such as endo‐ and exocytosis, intracellular trafficking, transcription, migration, and cytokinesis. As viruses navigate through cells, they may take advantage or be hindered by host components and machinery, including the cytoskeleton. This review delves into myosins' cell roles and compares them to their reported functions in viral infections. In most cases, the previously described myosin functions align with their reported role in viral infections, although not in all cases. This opens the possibility that knowledge obtained from studying myosins in viral infections might shed light on new physiological roles for myosins in cells. However, given the high number of myosins expressed and the variety of viruses investigated in the different studies, it is challenging to infer whether the interactions found are specific to a single virus or can be applied to other viruses with the same characteristics. We conclude that the participation of myosins in viral cycles is still a largely unexplored area, especially concerning unconventional myosins.
ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives
Authors: Waqas Syed Fakhar‐ul‐Hassnain , Sohail Aaqib , Nguyen Ariane Hai Ha , Usman Abdulai , Ludwig Tobias , Wegner Andre , Malik Muhammad Nasir Hayat , Schuchardt Sven , Geffers Robert , Winterhoff Moritz , Merkert Sylvia , Martin Ulrich , Olmer Ruth , Lachmann Nico , Pessler Frank
Published: July 2022

Background

Congenital ISG15 deficiency is a rare autoinflammatory disorder that is driven by chronically elevated systemic interferon levels and predominantly affects central nervous system and skin.

Methods and results

We have developed induced pluripotent stem cell‐derived macrophages and endothelial cells as a model to study the cellular phenotype of ISG15 deficiency and identify novel treatments. ISG15–/– macrophages exhibited the expected hyperinflammatory responses, but normal phagocytic function. In addition, they displayed a multifaceted pathological phenotype featuring increased apoptosis/pyroptosis, oxidative stress, glycolysis, and acylcarnitine levels, but decreased glutamine uptake, BCAT1 expression, branched chain amino acid catabolism, oxidative phosphorylation, β‐oxidation, and NAD(P)H‐dependent oxidoreductase activity. Furthermore, expression of genes involved in mitochondrial biogenesis and respiratory chain complexes II–V was diminished in ISG15–/– cells. Defective mitochondrial respiration was restored by transduction with wild‐type ISG15, but only partially by a conjugation‐deficient variant, suggesting that some ISG15 functions in mitochondrial respiration require ISGylation to cellular targets. Treatment with itaconate, dimethyl‐itaconate, 4‐octyl‐itaconate, and the JAK1/2 inhibitor ruxolitinib ameliorated increased inflammation, propensity for cell death, and oxidative stress. Furthermore, the treatments greatly improved mitochondria‐related gene expression, BCAT1 levels, redox balance, and intracellular and extracellular ATP levels. However, efficacy differed among the compounds according to read‐out and cell type, suggesting that their effects on cellular targets are not identical. Indeed, only itaconates increased expression of anti‐oxidant genes NFE2L2, HMOX1, and GPX7, and dimethyl‐itaconate improved redox balance the most. Even though itaconate treatments normalized the elevated expression of interferon‐stimulated genes, ISG15–/– macrophages maintained their reduced susceptibility to influenza virus infection.

Conclusions

These findings expand the cellular phenotype of human ISG15 deficiency and reveal the importance of ISG15 for regulating oxidative stress, branched chain amino acid metabolism, and mitochondrial function in humans. The results validate ruxolitinib as treatment for ISG15 deficiency and suggest itaconate‐based medications as additional therapeutics for this rare disorder.
Hierarchical stable election protocol for WSN‐based IoT inhabitant and environmental monitoring applications
Authors: Jeevanantham S. , Rebekka B.
Published: July 2022

Wireless sensor networks (WSNs) play an essential role in IoT applications, especially for long‐term data gathering and monitoring applications. The deployment field and the limited energy sources are two critical constraints directly influencing WSN lifespan, and both must be considered while designing a routing protocol for WSN‐based IoT applications. Routing the data consumes a significant amount of energy in such an extensive network. Several hierarchical clustering protocols have been developed in recent years to address this purpose. We propose a new hierarchical stable election protocol (HISEP), an improved version of the Stable Election Protocol (SEP) equipped with the Dual CH election algorithm using a new enhanced threshold formula. Accepting nodes' heterogeneity and incorporating Voronoi‐based cluster formation ensures that the 2D/3D WSN network stays alive for an extended period and the HISEP algorithm will be suitable for habitat tracking and environmental monitoring applications. The simulation results show that the proposed algorithm outperforms other protocols in terms of routing efficiency and network lifespan.
Busulfan associated pulmonary toxicity: A benign mimic of squamous cell carcinoma diagnosed in a bronchoalveolar lavage specimen
Authors: Selvaggi Suzanne M.
Published: July 2022

An uncommon case of iatrogenic cellular changes associated with busulfan therapy in a bronchoalveolar lavage of a 65‐year‐old woman who underwent bone marrow transplantation is presented and discussed. Chemotherapeutic changes are presented, and pitfalls discussed.
Standardized NEON organismal data for biodiversity research
Authors: Li Daijiang , Record Sydne , Sokol Eric R. , Bitters Matthew E. , Chen Melissa Y. , Chung Y. Anny , Helmus Matthew R. , Jaimes Ruvi , Jansen Lara , Jarzyna Marta A. , Just Michael G. , LaMontagne Jalene M. , Melbourne Brett A. , Moss Wynne , Norman Kari E. A. , Parker Stephanie M. , Robinson Natalie , Seyednasrollah Bijan , Smith Colin , Spaulding Sarah , Surasinghe Thilina D. , Thomsen Sarah K. , Zarnetske Phoebe L.
Published: July 2022

Understanding patterns and drivers of species distribution and abundance, and thus biodiversity, is a core goal of ecology. Despite advances in recent decades, research into these patterns and processes is currently limited by a lack of standardized, high‐quality, empirical data that span large spatial scales and long time periods. The NEON fills this gap by providing freely available observational data that are generated during robust and consistent organismal sampling of several sentinel taxonomic groups within 81 sites distributed across the United States and will be collected for at least 30 years. The breadth and scope of these data provide a unique resource for advancing biodiversity research. To maximize the potential of this opportunity, however, it is critical that NEON data be maximally accessible and easily integrated into investigators' workflows and analyses. To facilitate its use for biodiversity research and synthesis, we created a workflow to process and format NEON organismal data into the ecocomDP (ecological community data design pattern) format that were available through the ecocomDP R package; we then provided the standardized data as an R data package (neonDivData). We briefly summarize sampling designs and data wrangling decisions for the major taxonomic groups included in this effort. Our workflows are open‐source so the biodiversity community may: add additional taxonomic groups; modify the workflow to produce datasets appropriate for their own analytical needs; and regularly update the data packages as more observations become available. Finally, we provide two simple examples of how the standardized data may be used for biodiversity research. By providing a standardized data package, we hope to enhance the utility of NEON organismal data in advancing biodiversity research and encourage the use of the harmonized ecocomDP data design pattern for community ecology data from other ecological observatory networks.
Cardiac contractility modulation therapy improves health status in patients with heart failure with preserved ejection fraction: a pilot study (CCM‐HFpEF)
Authors: Linde Cecilia , Grabowski Marcin , Ponikowski Piotr , Rao Ishu , Stagg Angela , Tschöpe Carsten
Published: July 2022

Aims

This pilot study aimed to assess the potential benefits of cardiac contractility modulation (CCM) in patients with heart failure with preserved ejection fraction (HFpEF).

Methods and results

This was a prospective, multicentre, single‐arm, pilot study of CCM therapy in patients with HFpEF and New York Heart Association (NYHA) class II or III. Echocardiographic parameters were measured by an echo core laboratory to determine study eligibility. After CCM device implantation, patients were followed for 24 weeks. Overall, 47 patients (mean age 74.3 ± 4.4 years, 70.2% female) were enrolled, with left ventricular ejection fraction of 59 ± 4.4%, 63.8% with hypertension, 46.8% with atrial fibrillation, 40.4% with diabetes, 31.9% with at least one heart failure hospitalization in the prior year, 61.7% in NYHA class III, and Kansas City Cardiomyopathy Questionnaire (KCCQ) overall summary score of 48.9 ± 21.7. The primary efficacy endpoint (mean change in the KCCQ overall summary score) improved by 18.0 ± 16.6 points (p < 0.001) and there was an event‐free rate of 93.6% for the primary safety endpoint (device‐ and procedure‐related complications), as adjudicated by an independent physician committee.

Conclusion

This pilot study demonstrates that the benefits of CCM may extend to the HFpEF patient population. The significant improvement in health status observed, with no obvious impact on safety, suggests that utilization of CCM for patients with HFpEF could prove to be promising.
CSWS—Suppress confusion subregion in indoor image fingerprint localization
Authors: Liu Wen , Fan Tingting , Deng Zhongliang , Zhang Yingeng
Published: July 2022

Image data can provide rich content information, which has attracted a lot of attention in the field of indoor fingerprint positioning. However, indoor image information from different locations is characterized by high content repetition, and these repetitive regions can cause the problem of insufficient differentiation of adjacent image fingerprints or even fingerprint misclassification. To solve this problem, this article proposes a confusion subregion weighted suppression strategy in the image fingerprint database. First, duplicate regions (confusion subregions) are extracted from the fingerprint database using an appropriate salient region detection method. Then the similarity of these duplicate regions in Euclidean space is defined, and the degree of influence of these regions on the distinguishability of the fingerprint database is measured. Finally, the suppression of these duplicate regions is achieved in the original image fingerprint database by introducing weighted suppression coefficients. Experiments show that the algorithm proposed in this article can achieve significant results in the fingerprint localization task of real indoor scenes and effectively improve the localization accuracy.
Substance‐use simulation impairs driving capability in patients with cirrhosis regardless of hepatic encephalopathy
Authors: Acharya Chathur , McGeorge Sara , Fagan Andrew , Wade James B. , Lee Hannah , Luketic Velimir , Sterling Richard K. , Thacker Leroy , Bajaj Jasmohan S.
Published: July 2022

Driving is independently affected by cirrhosis and hepatic encephalopathy (HE) and alcohol/substance use, but their concomitant impact is unclear. We aimed to determine the impact of alcohol and other substances on driving‐simulator performance in cirrhosis with and without HE. Outpatients with cirrhosis and controls underwent cognitive testing and driving simulation for the following three conditions: baseline, wearing goggles simulating alcohol intoxication, and wearing goggles simulating opioid/benzodiazepine abuse. Outcomes were number of centerline crossings (CCs) and road‐edge excursions (REEs). We compared controls versus patients with cirrhosis then subjects with cirrhosis with and without HE for all conditions, using generalized linear modeling (GLM). Sixty subjects (17 controls, 43 with cirrhosis [Model for End‐Stage Liver Disease score, 10; 21 subjects with prior HE]) were included. Simulations showed higher CCs and REEs at baseline in patients with cirrhosis with and without HE versus controls. With alcohol‐ and substance abuse‐impairment goggles, CCs increased but REEs decreased in cirrhosis. In the GLM, a time and group interaction was seen (p < 0.001) for CCs and REEs. Patients with cirrhosis showed higher CCs and REEs at baseline than controls (CCs, p = 0.003; REEs, p = 0.0001) and higher CCs (p = 0.03) and lower REEs (p = 0.001) with alcohol‐simulating goggles. All groups were equally impaired with opioid/benzodiazepine‐simulating goggles (CCs, p = 0.49; REEs, p = 0.46). Controls with alcohol‐simulating goggles had similar CCs as the baseline of patients with cirrhosis (p = 0.98). conclusions: Simulating alcohol intake induces greater driving impairment in patients with cirrhosis versus controls, but similar patterns were seen with opioid/benzodiazepine‐simulating goggles. At baseline, patients with cirrhosis have simulator outcomes equivalent to intoxicated controls. Driving simulation with goggles modeling substance abuse could improve insight into driving errors and enhance driving rehabilitation in patients with cirrhosis.
Oral health promotion and programming provided by Aboriginal Community Controlled Health Organisations in South Australia
Authors: Poirier Brianna , Tang Samantha , Haag Dandara Gabriela , Sethi Sneha , Hedges Joanne , Jamieson Lisa
Published: July 2022

Background

Aboriginal Community Controlled Health Organisations (ACCHOs) play a critical role in supporting Aboriginal and Torres Strait Islander health in Australia. This article aims to identify and describe oral health programming and promotion provided by ACCHOs in South Australia.

Methods

All ACCHOs in South Australia were identified through the Aboriginal Health Council of South Australia. A targeted search strategy was designed to include the websites and social media pages (Facebook, Twitter, Instagram) for each organisation. Program characteristics were extracted and summarised, and oral health promotion content was analysed utilising content analysis.

Results

Twelve programs were identified across the 12 ACCHOs in South Australia. Of these, seven focused on oral health and five focused on nutrition. Oral health and nutrition information shared online by ACCHOs was extracted and aggregated into oral health and nutrition categories, which included reminders about visiting services, advocacy statements, oral hygiene messaging, appointment availability, education resources, and upcoming community‐based activities.

Conclusions

The evidence explored highlights the integral role ACCHOs play in oral health promotion and service delivery. It is critically important that ACCHOs are involved in development and implementation of oral health services to ensure programming reflects community knowledges and is effective in improving oral health equity.
A predictive model to estimate fever after receipt of the second dose of Pfizer‐BioNTech coronavirus disease 2019 vaccine: An observational cohort study
Authors: Chiba Satoru , Shinohara Kaoru
Published: July 2022

Background and Aims

Fever after coronavirus disease 2019 (COVID‐19) vaccination is generally a mild and benign event, but can cause excessive anxiety in younger adults. This study aimed to find key factors that include allergic diseases or physique that determine fever after vaccination.

Methods

We conducted an observational cohort study in our hospital to assess post‐COVID‐19 vaccination fever from April to June 2021. A total of 153 medical personnel aged 22–86 years of age were involved in the study to receive two doses, intramuscularly 21 days apart, of the Pfizer‐BioNTech COVID‐19 vaccine (30 μg per dose). Vaccination records were taken more than 72 h after vaccination. Clinical and laboratory variables (age, sex, allergy history, weight, height, serum hemoglobin concentration, and these derivatives) were examined by multivariable logistic regression analysis using the peak axillary temperature in the 4‐day period after the second vaccination as a dependent variable.

Results

No serious safety problems were detected. The incidence of a postsecond vaccination fever of 37.3°C or above was 29.4%. Logistic regression analysis found age, history of perennial allergic rhinitis, body surface area, body weight, percent overweight, and serum hemoglobin concentration as independent predictors of postvaccination fever. The characteristics of this individual were incorporated into the numerical model of human thermoregulation. The evaluation of this model had a sensitivity of 66.1% and a specificity of 90.7% in the detection of postvaccination fever. The multiple coefficient of determination (R2) was 0.410.

Conclusion

The COVID‐19 vaccine induced higher rates of fever during the 4‐day period after the second vaccination. Younger age, part of the allergy history, small and light body, and concentrated blood were associated with postvaccination fever.
Laddec® versus Bio‐Oss®: The effect on the healing of critical‐sized defect – Calvaria rabbit model
Authors: Gil Luiz Fernando , Nayak Vasudev Vivekanand , Benalcázar Jalkh Ernesto B. , Tovar Nick , Chiu Kai‐Jen , Salas Jaime Campos , Marin Charles , Bowers Michelle , Freitas Gileade , Mbe Fokam Dejolie Christelle , Coelho Paulo G. , Witek Lukasz
Published: July 2022

The aim of this study was to evaluate the in vivo performance of two different deproteinized bovine bone (DBB) grafting materials: DBBB (Bio‐Oss®) and DBBL (Laddec®), for the regeneration of critically sized (8 mm) defects in rabbit's calvaria. Three round‐shaped defects were surgically created in the calvaria of 13 New Zealand White rabbits proximal to the coronal suture in the parietal bone. Two of the defects were filled with one of the grafting materials while a third was left empty to serve as a negative control. Bone regeneration properties were evaluated at 4‐ and 8‐weeks after implantation by means of histological and histomorphometrical analyses. Statistical analyses were performed through a mixed model analysis with fixed factors of time and material. Histological evaluation of the control group evidenced a lack of bridging bone formation across the defect sites at both evaluation time points. For the experimental groups, new bone formation was observed around the defect periphery and to progress radially inwards to the center of the defect site, regardless of the grafting material. Histomorphometric analyses at 4 weeks demonstrated higher amount of bone formation through the defect for DBBB group. However, at 8 weeks, DBBL and DBBB demonstrated osteoconductivity and low resorption rates with evidence of statistically similar bone regeneration through the complete boney defect. Finally, DBBB presented lower soft tissue migration within the defect when compared to DBBL at both evaluation time points. DBBB and DBBL presented similar bone regeneration performance and slow resorption rates. Although both materials promoted bone regeneration through the complete defect, DBBB presented lower soft tissue migration within the defects at 4‐ and 8‐weeks.