bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategies and processes emergency department nurses consider important to safely manage during an influenza pandemic: A qualitative descriptive study
Authors:   , Lockett Jessica
Published: December 2021

The influenza virus is responsible for significant morbidity and mortality worldwide each year, with influenza pandemics occurring every 10 to 50 years and responsible for millions of deaths and substantial economic impact. Increasing globalisation through travel and trade means New Zealand is vulnerable to the risks of pandemic influenza, placing a strain on the healthcare system, putting lives at risk and posing a significant cost to the country. Emergency Departments are at the frontline of New Zealand’s healthcare system and are a crucial component in the response to an influenza pandemic, however little research has been done on the impact such an event would have on the nursing staff who work in this area and the care they provide to influenza patients.  This study aims to explore what New Zealand Emergency Department nurses perceive as the biggest challenges to nursing care and staff safety during an influenza pandemic, in order to provide information on how to ensure the engagement of these nurses at the frontline of the pandemic response. With a lack of evidence-based research available, a qualitative descriptive design was used to allow an exploration of the first-hand perspectives of Emergency Department nurses, gaining meaningful insights into a phenomena which has been little explored.  Sixteen nurses from two Emergency Departments participated in face-to-face interviews conducted using semi-structured questions. Raw data was transcribed, and an inductive approach was taken to data analysis, guided by the principles of both content and thematic analysis.  The findings demonstrate that Emergency Department nurses work in an environment that poses risk to patient and staff safety every day, and an understanding of these safety problems is provided in the theme ‘the everyday reality for Emergency Department nurses’. Working within this context shapes the fears that Emergency Department nurses hold about what could happen if an influenza pandemic were to affect New Zealand in the future, and are summarised within the theme ‘fears for a pandemic’. The final theme, ‘strategy and planning for pandemics’ provides insight into how Emergency Department nurses feel these issues could be managed within future pandemic planning at Emergency Department, District Health Board and government level.  This thesis identifies both existing and potential future safety concerns in relation to the management of influenza in New Zealand Emergency Departments, affecting the safety of patients and staff. It also provides specific multi-level and multi-agency recommendations for future pandemic plans that could help to mitigate the significant risks highlighted by those who work within the system every day.
Transport Properties of Rare Earth Nitrides
Authors:   , Holmes-Hewett William
Published: December 2021

In this thesis we investigate the transport properties of SmN, NdN and GdN, members of the rare earth nitride series of intrinsic ferromagnetic semiconductors. GdN is the central member of the series with seven occupied majority spin 4f states and seven empty minority spin 4f states. Both the filled and unfilled 4f states are some few eV away from the conduction and valence band extrema, resulting in transport properties which are dominated by the extended Gd 5d band. The half filled 4f shell, with zero net orbital angular momentum, furthermore simplifies calculations and as such GdN is the most studied both experimentally and in theory. As one moves to lighter members, the filled 4f states become unfilled states in the conduction band and the 4f shell now has a net orbital angular momentum. Calculations concerning these members are now significantly more complicated, and as such there exists a wide range of predictions concerning the conduction band minima in the lighter rare earth nitrides. To inform the current theoretical and experimental literature we report on three studies concerning the transport properties of SmN, NdN and GdN.  To begin we report on the anomalous Hall effect in SmN, NdN and GdN. Under the symmetry of the rock-salt rare earth nitrides the magnitude of the anomalous Hall effect can imply the wave function of the conduction electron (i.e. d or f band). Measurements of the anomalous Hall effect in moderately doped samples are used to show the conduction channel in SmN and NdN is an f band or hybridised f/d band. Furthermore the sign of the anomalous Hall effect can be used to determine the orientation of the spin magnetic moment of the conduction electrons. Optical measurements of SmN, NdN and GdN films are then reported. Optical measurements provide a probe of the band structure of a material via direct transitions between the valence and conduction bands. Measurements of reflectivity and transmission on undoped SmN and NdN films were used to locate the unfilled majority spin 4f bands which form the conduction band minima in each material. Finally a preliminary study of heavily doped SmN, NdN and GdN is discussed. Structural measurements show a reduced lattice parameter while transport results find a significantly enhanced conductivity in heavily doped films. The Curie temperature is found to be enhanced and optical measurements show an increased absorption and red-shifted optical edge in doped films. The superconducting state of SmN is discussed and it is shown only to be present in moderately doped films, i.e. superconductivity is not present in undoped or degenerately doped SmN, within our measurement limits.
Joint Decisions in Residential Choice
Authors:   , Johnsen Edward
Published: December 2021

Economic agents frequently make joint decisions, which often require a compromise by some or all of the participants. We propose an econometric model in which groups of agents make a joint decision; each agent has preferences modelled using a combination of multi-nominal logit and conditional logit parts. We combine these marginal preferences to create a joint set of probabilities of the group making a particular choice, which enables parameter estimation by maximum likelihood. We can also make the weight applied to an individual agents preferences depend on characteristics of the agent or group. To demonstrate the use of the model, data is obtained from the New Zealand Household Travel Survey. We estimate our model to show how households might make the joint decision of where to live, given that different household members have different work locations.
Verismo opera: how bel canto technique protected the voices of its singers
Authors:   , Chen Zeyu
Published: December 2021

Verismo is a style of opera composition that was influenced by a significant movement in Italian literature from the end of the nineteenth century to the beginning of the twentieth century. It is characterised by the true-to-life portrayal of rural or urban poverty, often showing a robust regional lifestyle as well as serving as the introduction to the region's representative songs and dances. Historically, the singing of verismo opera posed some problems for singers in regards to their stamina and the longevity of their career. As a student, I attempted to sing this type of music, but I felt unable to sing it well; my difficulties and the problems associated with the performance of verismo, therefore, fascinated me. Rationalising that proper vocal technique was the answer to these problems, I then concentrated on long-term systematic bel canto training in China and New Zealand.  In most cases, the study of bel canto technique is a fundamental part of the process of learning vocal music for classical singers. In addition to laying out the background of verismo and bel canto, my exegesis demonstrates how singers can learn to sing verismo opera well without damaging their voices, which will help them extend their stamina and the length of their career. I especially investigate the differing use of the body needed for singing each type of music. Researching bel canto, I have listened to different singers' recordings and have written short critiques of their voices, focusing on how they developed bel canto to sing verismo. I have focused on bel canto and verismo works for my repertoire and can apply the techniques safely based on bel canto training. To articulate this knowledge, I take three different arias (one bel canto aria, two verismo arias) as case studies to analyse, to demonstrate the points I want to make. In addition, as a native Mandarin Chinese speaker, I focus on how Mandarin native speakers deal with singing Italian, and I articulate techniques to help other Mandarin speakers learn bel canto. Overall, my research will have practical and artistic value for younger students in helping them to understand the challenges of singing verismo opera.
The Effect of Ionising Radiation on the Luminescence Properties of Fluoroperovskites
Authors:   , Schuyt Joseph
Published: December 2021

The luminescence of crystalline compounds can be used to monitor many physical phenomena, including doses of ionising radiation. Optically stimulated luminescence (OSL), thermoluminescence (TL), and radiophotoluminescence (RPL) have been successfully employed in dosimetry. However, few materials possess both the structural and luminescence properties required for medical dosimetry. This thesis aimed to investigate the luminescence features of the class of compounds known as fluoroperovskites. Emphasis was placed on studying the effects of irradiation on the luminescence properties, such that the compounds could be evaluated regarding potential applications in clinical dosimetry. Samples were primarily characterised using photoluminescence (PL), radioluminescence (RL), OSL, RPL, TL, and transmittance spectroscopy.  OSL was observed in the majority of samples due to the existence of electron trapping F-type centres. F-centre/Mn complexes were observed in all AMgF3:Mn compounds after irradiation and the energy levels of the complexes in each compound were experimentally determined. The most promising potential dosimeter host material was the near tissue-equivalent NaMgF3. When doped with Mn2+, the compound exhibited RPL via the formation of F-centre/Mn complexes and OSL via several trapping centres. The RPL could be probed independently to the OSL such that the compound could function as a hybrid OSL/RPL dosimeter. In the NaMgF3:Ln compounds, RPL occurred via the radiation-induced reduction Ln3+ → Ln2+ for Ln = Sm, Dy, and Yb. The reduction Sm3+ → Sm2+ was highly stable and could be non-destructively probed independently to the OSL. The Sm doped compound also exhibited radiation-induced conductivity that could be coupled with the RL, such that the compound could function as a real-time hybrid optical/electrical dosimeter. Charge kinetics, thermal quenching, and binding energy models were developed and applied to the compounds.   Finally, a two-dimensional readout system was designed and constructed. The capabilities of the system were evaluated using the OSL of NaMgF3:Eu and NaMgF3:Mn. Sensitivities to doses from < 10 mGy to > 1 Gy were obtained along with sub-millimetre spatial resolutions.
Discovery and Biosynthesis of Natural Products from New Zealand Soil Metagenome Libraries
Authors:   , Stevenson Luke
Published: December 2021

Antibiotic discovery rates dramatically declined following the “golden age” of the 1940’s to the 1960’s. The platforms that underpinned that age of discovery rested upon laboratory cultivation of a small clade of bacteria, the actinomycetes, primarily isolated from soil environments. Fermentation extracts of these isolated bacteria have provided the majority of antibiotics and anticancer small molecules still used today. By applying modern genetic analysis techniques to these same environmental sources that have previously yielded such success, we can uncover new biosynthetic pathways, and bioactive compounds. The work described in this thesis investigated New Zealand soil metagenomes for this purpose.  Four large metagenome libraries were constructed from the microbiomes of diverse soil environments. These were then interrogated by a functional screening approach in a knockout Escherichia coli strain, to recover a large collection of the biosynthetic gene clusters responsible for bacterial secondary metabolite production. Using different modes of bioinformatic analysis, these gene clusters were demonstrated to have both phylogenetic divergence, and functional difference from bacterial biosynthesis pathways previously discovered from culture based studies.  Two additional biosynthetic pathways were recovered from one of these metagenome libraries, and in each case found to have novel genetic features. These gene clusters were further studied by heterologous expression within Streptomyces albus production hosts. One of these gene clusters produced small aromatic polyketide compounds, the structure of one of which was solved by chemical analytic techniques, and found to be a new chemical entity.  The second gene cluster was demonstrated to have similarity to known aureolic acid biosynthesis gene clusters – a class of potent anticancer natural products. Heterologous expression resulted in the production of many metabolites, two of which were characterised and found to be new members of this chemical class.  The research in this thesis both validates the use of metagenomic analysis for future natural product discovery efforts, and adds to a growing body of evidence that understudied clades of bacteria have an untapped biosynthetic potential that can be accessed by metagenomic methods.
Effects of BMP15 and GDF9 on Ovine Oocytes in an In Vitro Maturation System
Authors:   , Singh Aanchal
Published: December 2021

Oocyte developmental competency is the intrinsic measure of oocyte quality and the capacity for a mature oocyte to support the early stages of embryo development and implantation. Oocyte-secreted factors (OSFs), such as growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15), play a pivotal role in regulating the synchrony of various complex maturation events within the cumulus-oocyte complex (COC) through the induction of paracrine and endocrine signalling. These proteins act synergistically to influence the proliferation and differentiation of granulosa cells (GCs), cumulus cell (CC) expansion, promote survival, ovulation, the attainment of developmental competency and fertility. Species-specific ratios suggest that poly-ovulatory mammals have increased fecundity due to high ratios of GDF9:BMP15, which is directly reflected in their large litter size. Interestingly, it has also been found that higher ratios of GDF9:BMP15 also increased blastocyst rate in sheep implying that these embryos develop from oocytes that are more developmentally competent.  In this study, I investigated the hypothesis that supplementing a commercial in vitro maturation (IVM) system with a high ratio of GDF9:BMP15 would increase the developmental competency sheep oocytes; a species with low-moderate litter size. To test this hypothesis, ovine oocytes were matured in a biphasic IVM system containing GDF9 and BMP15 at three divergent ratios (1:6, 1:1, 6:1). The results herein show that the 6:1 ratio resulted in higher levels of reagent transfer to the ovine oocyte through gap junctions (GJs) after 24 hours of incubation. Similarly, it was also observed that at the higher ratio, glutathione (GSH) levels were higher at 7.5 hours of incubation. The high GDF9:BMP15 ratio also facilitated the increased consumption of pyruvate by the COC consistently throughout the culture period. Importantly, the high GDF9:BMP15 ratio showed higher expression of the gene that encodes GJ (CX43) at 24 hours relative to the control. It was also demonstrated through decreased apoptotic factor (BAX:BCL2) ratios, that the addition of OSFs, regardless of ratio, protected against cell death. In summary, this study provides novel results that support the notion that a high GDF9:BMP15 ratio improves oocyte quality by delaying the timing of meiotic resumption. This subsequently improves the transport of key metabolites and antioxidants to protect against oxidative stress and cell death and aid in the completion of maturation, ultimately resulting in the increased developmental competency observed in high fecundity poly-ovulatory species.
Reproductive timing and investment decisions of a protogynous hermaphroditic coral reef fish species
Authors:   , Mitterwallner Pauline
Published: December 2021

Life-history theory suggests that an organism must balance its available energy between two competing physiological processes to maximize fitness: reproduction and somatic growth. Energetic trade-offs are a fundamental concept of life history theory and form the basis of intra- and inter-specific variation in life-history strategies. In fishes, reproduction-growth trade-offs are an essential component of life-history optimization. This is particularly true for species with protogynous sex- change (the most common reproductive mode among coral reef fish species), where reproductive success rapidly and disproportionally increases with body size/ corresponding social status. In such systems, lifetime fitness is inherently linked to patterns of growth and energy allocation strategies determined by an individual’s size-specific rank within the dominance hierarchy. However, energy allocation strategies in a protogynous species may not only be a function of body size. Coral reef fish species are exposed to extremely variable environmental conditions and this can favour the evolution of strategies that utilize good times and avoid disadvantageous times for reproduction. Consequently, size- specific parental investment decisions may vary greatly in time and space according to environmental cues. My thesis focuses on the protogynous reef fish, Thalassoma hardwicke (the sixbar wrasse), which is extremely abundant on shallow coral reefs throughout the Indo-Pacific region. Specifically, I evaluate patterns of spawning and reproductive investment as a function of body size, social status, lunar phase and other environmental parameters. I address the question of whether females/males of differing size make different fitness-related decisions when away from spawning sites, and I evaluate context-dependency in these decisions. Finally, I will attempt to reconstruct the developmental histories (e.g., larval growth rates) of individuals from otoliths to evaluate potential relationships between developmental histories and fitness attributes.
Upliving - Student Accommodation
Authors:   , Roberts Joshua
Published: December 2021

This research proposal looks into the future at an increase in student population, an increase in basic living costs, the looming issues with densification of Wellington City, and its development to the transport infrastructure. The project aims to create accommodation for students going through university while providing a simple and cohesive mode of transport linking the CBD. The biggest motivator for Upliving is Wellington’s great potential for infill buildings in spaces such as cracks between buildings; above roads; atop buildings; underutilised areas within an urban context; temporarily empty sites awaiting future development; and car parks (particularly with the development of transport infrastructure, eliminating the need for as many vehicles within the city). The development would be funded by universities in collaboration with the city to help compensate for the rising education costs and rising living costs. It will provide better transport within the city, opening up more potential for development with less infrastructure to facilitate the currently high vehicle usage. The goals of the architecture are to accommodate students, maintain a minimal building footprint, effectively use circulation spaces to minimise an inclination to damage of property, create flexible spaces, maintain a simple structure for rapid construction, provide active communal spaces, establish connections to university campuses, generally link the Wellington’s CBD, use underutilised spaces, and maintain a contemporary identity that blends into the urban context. There are many aspects involved in this research portfolio, including the notion of research by design through the use of an in-depth iterative process, precedent investigations, client/occupant research, detailed design explorations of large and small scales, an outcome, and a critical reflection highlighting possible changes and a direction for further development.
Next Generation Architect
Authors:   , Le Compte Terian
Published: December 2021

The stereotype of an architect is expensive, with minimal consideration and awareness towards cost and budget. This is damaging the reputation of the profession. This thesis will look at the Next Generation Architect who combines both design and construction to understand the cost implications from the start to the completion of the project. A Next Generation Architect works with an innovative approach that is more affordable to how they currently practice. They design houses that are both economical and retain a strong design quality, through the value of the aesthetics, materials, and living conditions. An effective architect should be able to design, mindful of costs, along with the implications involved and actively manage the costs, based on design decisions made.  This research will commence by exploring tactics of affordability, housing economics, and costing and design tactics, to portray exemplars of affordable housing. Elements will be costed with data from QV costbuilder implemented through the use of Building information modelling (BIM) through Revit. The architectural value will explore the use of materials, living conditions, economics, and lifecycle to optimise the design. A series of precedents will be analysed to gain an understanding of the techniques of affordable methods used within New Zealand’s construction industry.  This thesis aims to provide architecturally designed and preliminarily costed affordable architectural products. Through a series of architecturally designed standalone houses that explore affordability, and tested through the use of architecture as a product across four sites, displaying different site conditions of the Wellington region.  This thesis will portray efficient, economic building and design techniques and cost monitoring while retaining a strong architectural quality.  The aim is to convey the contemporary role of a Next Generation Architect who works accurately with value. Who is mindful of costs and designs economically, without compromising the quality of an architecturally designed product.
Indigenous Narratives In Parametric Design. Reconnecting With Māori Identity Through The Development Of Sculptural Cartography As Architectural Interventions
Authors:   , Bartlett Jeffrey
Published: December 2021

Re-connecting with Māori identity through parametric design has been investigated through this body of research by focussing on mātauranga Māori (Māori knowledge). Ultimately asking: “There is a place for parametric design to help translate Māori narratives, values and procedures into architectural form”. The designer’s intent through this body of research was to re-enforce old ties with local iwi, re-learn one’s whakapapa (stories/narratives), and re-connect with one’s sense of self through embedding this knowledge into a coded design. The objective was to achieve a design output that is fundamentally built on mātauranga Māori and cultural practices of Ngāti Kahungunu (iwi in the Hawkes Bay that extends down the East coast of New Zealand’s North Island). When a design begins with such an intent, the generated output is unexpected, surprising and changes perception of what a particular structure is meant to be or do. The ideas touched upon in this research is merely a seed to what can be achieved when using parametric design to produce a culturally significant design. Finding one significant cultural aspect, in this case the power of loci, is one of the most important steps in building the design tikanga (protocols/scope) that will find its way into all aspects of the designs produced. This informed the reasoning for the parameters used, the range of variation and how one step progressed to the next.
Constructing a Biopic Screenplay: Fictional Invention in the Biopic with Scant Evidence
Authors:   , Chakravarty Indranil
Published: December 2021

As a creative practice research project, this thesis sets out to write a screenplay about Suresh Biswas (1861-1905), a little-known Bengali adventurer who was a wild-life trainer and circus-performer in Europe and later became a Captain in the Brazilian army. The early biographies of Biswas, based on limited and unreliable evidence, pose a challenge to the screenwriter in terms of narrative reconstruction of his life as a biopic. While more information has become available recently, this project examines the creative and critical issues associated with researching this figure, overcoming the problem of scant evidence and positioning him within a presentist context. Drawing on Rosenstone’s conceptual model for understanding how historical knowledge manifests in fictional narratives, it investigates the nature and function of fictional inventions in biopics and the ways in which screenplays make creative use of evidence. In writing Biswas’ biopic, I use the microhistorical research method, knowledge about biopic script-drafting processes, and Bhabha’s notion of ‘vernacular cosmopolitanism’ to present Biswas as a non-Western, non-elite 19th century cosmopolitan, thereby constructing a counter-narrative to the dominant discourse of cosmopolitanism as a matter of exclusive Western, elite privilege. I argue that it is through a judicious mix of fictional invention and a diligent study of evidence that a screenwriter can get closer to the historical subject. The thesis thus initiates in practice, moves to biopic history and criticism, reverts to practice with knowledge about research and writing that not only enables me to overcome my screenwriting problem but also leaves behind a set of insights for other screenwriters working with scant biographical evidence.
The Requiem Mass and Sacred Jazz: A Study of catholic Liturgical Forms in the Genre of Sacred Jazz
Authors:   , White John
Published: December 2021

This exegesis examines the role of religious and spiritual influence on works by jazz composers as related to my composition, Requiem: a Suite of Jazz Orchestra, a jazz suite based on the Requiem Mass. The exegesis details the Catholic origins of the Requiem and the Mass as musical forms and traces their lineages into the twentieth and twenty-first centuries as concert works and memorials not bound by liturgical function. These forms and their lineages frame the development of both religious and religion-inspired musical works in the cultural climate of 1960s America. In particular, I focus on two composers, Mary Lou Williams and Duke Ellington, both of whom composed large-scale sacred works related to the jazz idiom. This project situates religion, primarily Catholicism, and spirituality in the context of jazz composition, and discusses music composed in this vein, including my own work influenced by the Catholic liturgical tradition.
Development of a Generic Dual Fuel ECU for Common Rail Diesel Engine Control
Authors:   , Frogley Luke James
Published: December 2021

Rising costs of diesel fuel has led to an increased interest in dual fuel diesel engine conversion, which can offset diesel consumption though the simultaneous combustion of a secondary gaseous fuel. This system offers benefits both environmentally and financially in an increasingly energy-conscious society. Dual fuel engine conversions have previously been fitted to mechanical injection systems, requiring physical modification of the fuel pump. The aim of this work is to develop a novel electronic dual fuel control system that may be installed on any modern diesel engine using common rail fuel injection with solenoid injector valves, eliminating the need for mechanical modification of the diesel fuel system.  The dual fuel electronic control unit developed replaces up to 90 percent of the diesel fuel required with cleaner-burning and cheaper compressed natural gas, providing the same power output with lower greenhouse gas emissions than pure diesel. The dual fuel system developed controls the flow of diesel, gas, air, and engine timing to ensure combustion is optimised to maintain a specific torque at a given speed and demand. During controlled experimental analysis, the dual fuel system exceeded the target substitution rate of 90 precent, with a peak diesel substitution achieved of 97 percent, whilst maintaining the same torque performance of the engine under diesel operation.
Architecture for the poor and unprivileged of Jakarta
Authors:   , Waller Patrick
Published: December 2021

As the world becomes increasingly urbanised, cities are forced to manage significant population increases. Jakarta, in Indonesia, has a significant population that is visibly living below the poverty line which suggests the city was not fully prepared to accommodate the radical growth. With such a large number of people living in poverty, and there being a lack of affordable housing Jakarta faces an issue where a significant number of these people are forced to live in informal settlements, which are spread throughout the city. These informal settlements, known as Kampungs are typically made up of dense clusters of single or two story residential structures packed together in communal areas. The erection of these houses often results in unplanned but functional networks of footpaths. These urban arrangements normally have a lack of sanitary infrastructure. The government’s current plans to mitigate this issue are by forced evictions, and moving the informal settlement residents into subsidised social housing apartment buildings. Generally, people are against these forced evictions and in many cases they are forced to leave, or simply rebuild on top of the rubble of their old homes. How can architecture support the existing social connections within the community, while improving the living conditions of the residents in the informal settlements of Jakarta? This research proposes a community centre design which is able to provide necessary facilities to the informal settlements. Although the residents are not in need of a new housing design, this research focuses on providing facilities to improve the quality of life. The research takes into account extensive site, literature, and precedent analysis; to develop a design criteria which aims to produce positive neighbourhood development. Traditional Indonesian architecture has a heavy influence on the form and construction material, with the intention to give the opportunity for the community to get involved in the construction and maintenance of the building. The final design result is a community centre with a large auditorium space for community gatherings, and support spaces which include emergency accommodation, teaching facilities, exhibition space, workshop space, sanitary facilities, recycling management centre, and retail spaces. This architectural intervention provides a place for the community to come together and to have a better quality of life while still being able to live in their personally constructed and designed homes.
Small batteryless wireless solar powered GPS receivers for subcentimeter land deformation monitoring
Authors:   , Olds Jonathan Paul Simon
Published: December 2021

We design, implement, and validate a unique permanently deployed land deformation monitoring system using small (brick sized), cheap (approximately $100 USD), batteryless, solar powered singleband GPS wireless sensor nodes. Both hardware and software were designed, implemented, and validated by us. Constraints by our hardware and application prompted us to design a unique distributed relative static positioning algorithm designed for intermittent poor quality phase observable measurements, for sites with high multipath and high node densities requiring good solution accuracies; the static solutions were calculated on a daily basis. Our algorithm used a quarter of the bandwidth that would typically be required for an RF link used for a comparable application. GPS on time was observed to vary greatly from as little as 0.5 hours a day in winter to over 8 hours a day and summer in one of our tests. Typical solution precision was 4 mm 2DRMS. Simulations predicted an undesirable slowly changing solution bias that would repeat every year.
Technical challenges of a lightweight, scalable, global paywall system
Authors:   , Anandaraj Puneeth
Published: December 2021

This thesis presents the technical challenges that were faced while building a lightweight, scalable, global news paywall system. It also presents the common events while establishing a start-up company and also its unique events while building the start-up, Ripple Media Ltd. The project was based on a research within the Victoria University’s School of Information Management, “Digital Commons or Digital Enclosures: The Future of Online Content Distribution.” The project focuses on providing a platform that would solve the problems of online distribution and monetisation strategies. Ripple Media Ltd has conducted a market research that would give insights on news monetisation and building a product / platform addressing the online content distribution.
Decidable Subtyping for Path Dependent Types
Authors:   , Mackay Julian
Published: December 2021

Path dependent types form a central component of the Scala programming language. Coupled with other expressive type forms, path dependent types provide for a diverse set of concepts and patterns, from nominality to F-bounded polymorphism. Recent years have seen much work aimed at formalising the foundations of path dependent types, most notably a hard won proof of type safety. Unfortunately subtyping remains undecidable, presenting problems for programmers who rely on the results of their tools. One such tool is Dotty, the basis for the upcoming Scala 3. Another is Wyvern, a new programming language that leverages path dependent types to support both first class modules and parametric polymorphism. In this thesis I investigate the issues with deciding subtyping in Wyvern. I define three decidable variants that retain several key instances of expressiveness including the ability to encode nominality and parametric polymorphism. Wyvfix fixes types to the contexts they are defined in, thereby eliminating expansive environments. Wyvnon-μ removes recursive subtyping, thus removing the key source of expansive environments during subtyping. Wyvμ places a syntactic restriction on the usage of recursive types. I discuss the formal properties of these variants, and the implications each has for expressing the common programming patterns of path dependent types. I have also mechanized the proofs of decidability for both Wyvfix and Wyvμ in Coq.
Exploring the Creation of Organisation Strategy when Commercialising a New Technology
Authors:   , Mettrick Michael
Published: December 2021

This thesis takes a mixed methodology approach to exploring the creation of organisational strategy from the perspectives of both the classical strategy frameworks and Sarasvathy's theory of effectuation. The experience of working within the Masters of Advanced Technology Enterprise (MATE) is portrayed through using an ethnographic approach in conjunction with critical reflection to build ‘thick descriptions’. Following this descriptive phase, analysis is conducted through both classical strategic management frameworks and Sarasvathy’s theory of effectuation. The multifaceted approach was chosen enable a deep understanding of the variety of strategic directions, reasoning’s that were undertaken throughout the year.
Vorinostat, a Histone Deacetylase Inhibitor, as a Candidate Therapy to Treat Liver Pathology in a Niemann-Pick type C Disease Mouse Model
Authors:   , Hammond Natalie
Published: December 2021

Niemann-Pick type C (NPC) disease is a rare neuro-visceral, lysosomal storage disorder for which no effective therapy yet exists. A recessive mutation in the late endosomal/lysosomal cholesterol transport genes NPC1 (95%) or NPC2 (5%) are the causative factors which leads to an accumulation of unesterified cholesterol and sphingolipids in the late endosome/lysosome. It is a build-up of these lipids that, in the majority of cases, ultimately leads to premature death prior to adolescence. In recent years, an imbalance of histone acetylation in a yeast model of NPC disease and subsequently an increased expression of histone deacetylase genes in NPC patient fibroblasts relative to healthy controls was discovered. This led to the finding that Vorinostat (suberoylanilide hydroxamic acid (SAHA); Zolinza®) a histone deacetylase inhibitor (HDACi) drug, rescued unesterified cholesterol accumulation in NPC patient fibroblasts. From these findings in NPC patient fibroblasts, a Phase I clinical trial testing the efficacy of orally-administered Vorinostat in adult NPC disease patients commenced in 2014; however, the therapeutic efficacy of Vorinostat in a whole animal model of NPC disease has not been investigated and is thus unknown. In this thesis, the therapeutic efficacy of intra-peritoneal administered 150 mg/kg Vorinostat in the Npc1nmf164 mouse was explored. This internationally approved HDACi reduced liver disease by decreasing lipid accumulation without increasing expression of NPC1; however, the treatment did not delay weight loss, onset of ataxia and premature death, possibly due to insufficient concentrations penetrating through the blood brain barrier. Transcriptome analysis suggested Vorinostat improved liver disease in a pleiotropic manner, not surprising given the epigenetic nature of HDACi at the gene expression level. Overall, the results herein are of particular importance to the current clinical trial where the therapeutic efficacy is being investigated without any knowledge of efficacy in an animal of NPC disease.
Towards the production of tikitericin: A novel peptide from Thermogemmatispora strain T81
Authors:   , Baker Benjamin
Published: December 2021

The utilisation of natural products for treatment of human ailments has been rooted in various cultures for centuries. Extraction of natural products has been essential for the discovery of new drugs and inspiration for synthetic analogues. Since the success of penicillin, microbial natural products have been of interest. Genome mining of Thermogemmatisporastrain T81, a thermophile from the Taupo Volcanic Zone, found the potential for the production of novel ribosomally synthesised and post-translationally modified peptides (RiPPs). Previous work showed that T81 exhibited antimicrobial activity against a wide variety of extremophillic bacteria. Although the three thiopeptides encoded forin the genome of T81 have not been found, the lanthipeptide tikitericin has recently been isolated and described. Unfortunately tikitericin is produced in low quantities by T81 andbioactivity data has not yet been obtained. Because of its potential antimicrobial activity, different routes to produce it are of interest. The aim of this project wasto synthesisetikitericin by solid phase peptide synthesis. MS imaging was also utilised to search for the presence of tikitericin as an antimicrobial agent in situ.
Exploring the structure-activity relationship of Mincle ligands
Authors:   , Stone M. Rhia L.
Published: December 2021

Mincle is a C-type lectin that plays a critical role in the body’s innate immune response to bacteria and fungi. Compounds identified as ligands for Mincle include trehalose and glycerol esters of complex long chain fatty acids. Harnessing its ability to activate the immune system, trehalose dimycolate has been used as a vaccine adjuvant and for anti-cancer treatment, highlighting the potential use of Mincle immunomodulators in a medical context. To further understand the receptor-ligand interactions and optimise biological activity, the structure-activity relationship of Mincle ligands was investigated through the synthesis and biological evaluation of a series of modified ligands. The preparation of carbohydrate modified trehalose dibehenates was attempted in order to assess the importance of hydroxylprotein interactions, and despite the syntheses being incomplete, improvements on literature methodologies for the regioselective modification of α,α′-D-trehalose were developed. Simplified analogues of the glycerol based natural products identified as Mincle ligands containing straight chain and iso-branched lipids were prepared to evaluate the significance of the branch and establish whether there is a relationship between lipid length and Mincle activation. The corresponding trehalose diester analogues were also synthesised to gauge the capacity of the protein to tolerate changes in the carbohydrate portion of ligands.
Low Correlation Codes for Sonar Systems
Authors:   , Pratap Rajiv
Published: December 2021

Sonar is a vital technology for the detection of objects in the water. Sonarsystems have been redefined over many decades, but research is still beingconducted into optimal detection methods. Codes, and the filters thatprocess the codes, have been at the forefront of this research. An importantobjective has been the minimization of interference caused by reflections.Matched filters are commonly used in sonar systems. They are equivalent tocorrelation filters, which are bound by the Welch bound. The Welch boundgoverns the minimum peak correlation for points outside of detection.This thesis investigated matched filters and their bounds, and it wasfound that by relaxing the condition for detection, properties beyond theWelch bound could be achieved. By relaxing these conditions, the Welchbound no longer applies, and so a modified Welch bound was developedto accurately investigate the nature of these codes. In this thesis, methodsto generate codes for these new codes were investigated. Generating codesfor a matched filter is a non-convex problem, so gradient based methodswere utilised. Methods to improve correlation and power characteristicswere developed, along with methods for mapping a sequence for use witha digital transmitter having particular limitations. Mis-matched filters wereused to improve signal characteristics that may be lost due to this mapping.The performance of the generated codes was evaluated, and the rela-tionships between input parameters and output properties of the resultingsignal were observed. These performance assessments demonstrate thattradeoffs are required between various properties, and a balance is neededto obtain codes useful for sonar. The optimization was parametrized by anexample set of requirements for sonar. The signals were found to meet the given requirements, and when compared to codes typically used in sonar,the optimized signals were shown to have significantly better correlationproperties. Furthermore, compared to the general bounds for the propertiesof codes, it was found that the new codes had nearly optimal properties,and performed better than equivalent codes bounded by the Welch bound.The performance of codes were also investigated in a water tank toverify their feasibility. There were several additional considerations whichlimit codes that can be tested, and once these are taken into account thetest provided a robust method to verify the design process. Initial testsshowed results that differed from simulations, but after the inclusion ofzero padding before upscaling, the results from empirical testing agreewith simulation.Summarizing the research in this thesis, a new set of codes were devel-oped using a gradient based optimization method. The codes were mappedto a digital transmitter, and the filter adjusted using a mis-matched filter. The optimization was shown to generate near optimal codes which met allthe given sonar system requirements
A Space to Call Our Own, an investigation into designing for play in urban environments
Authors:   , Webber Hayley
Published: December 2021

Play is an act of discovery and stimulation. As children, we play to learn and grow. As adults, we play for freedom and to escape from reality. The action of play is a largely neglected aspect of peoples experience in urban public space. It is the un-functional and impractical use of the environment that fulfils a human instinct and curiosity that can spark conversation and spontaneity in public spaces. The development of the built environment has centred on improving the efficiency of daily life and little attention has been given to the informal synergies that urban public space can enable. Yet this space plays a central role in the formation of our culture and communities. With increasing trends of migration and urbanisation, New Zealand has become a multicultural society, but the quality of our public spaces and a distinct lack of meaningful interaction is causing increased levels of social fragmentation. The universal action of play can be used as a design tool to increase the level of meaningful activity and interaction in these spaces.   This thesis aims to understand how the inclusion of play and playful behaviour can create polycentric environments that can contribute to the reversal of social fragmentation between our ethnic communities and improve social cohesion and resilience within Newtown and Berhampore, socially deprived suburbs in Wellington, New Zealand.   The method of this research focuses on combining methods of spatial assessment and community engagement to develop a holistic understanding of play across social, cultural and physical dimensions. Observational studies, public surveying and community workshops combined with a comparative study across a series of case studies provided a foundation of knowledge that was then able to be applied to the design of physical playful spaces.  The design response across three test sites vary in scale between small tactical additions and overall redesign of space. These responses display how play can facilitate new forms of social interaction and spark spontaneity. The improved sense of community, familiarity and overall playfulness, increase overall resilience and overturn effects of social fragmentation. This thesis demonstrates how landscape architects can engage with the concept of play to reignite passion within a community and support social network growth.