bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiac Events After Radiation Therapy: Combined Analysis of Prospective Multicenter Trials for Locally Advanced Non–Small-Cell Lung Cancer
Authors: Dess Robert T. , Sun Yilun , Matuszak Martha M. , Sun Grace , Soni Payal D. , Bazzi Latifa , Murthy Venkatesh L. , Hearn Jason W.D. , Kong Feng-Ming , Kalemkerian Gregory P. , Hayman James A. , Ten Haken Randall K. , Lawrence Theodore S. , Schipper Matthew J. , Jolly Shruti
Published: March 2017

Purpose

Radiation therapy is a critical component in the care of patients with non–small-cell lung cancer (NSCLC), yet cardiac injury after treatment is a significant concern. Therefore, we wished to elucidate the incidence of cardiac events and their relationship to radiation dose to the heart.

Patients and Materials

Study eligibility criteria included patients with stage II to III NSCLC treated on one of four prospective radiation therapy trials at two centers from 2004 to 2013. All cardiac events were reviewed and graded per Common Terminology Criteria for Adverse Events (v4.03). The primary end point was the development of a grade ≥ 3 cardiac event.

Results

In all, 125 patients met eligibility criteria; median follow-up was 51 months for surviving patients. Median prescription dose was 70 Gy, 84% received concurrent chemotherapy, and 27% had pre-existing cardiac disease. Nineteen patients had a grade ≥ 3 cardiac event at a median of 11 months (interquartile range, 6 to 24 months), and 24-month cumulative incidence was 11% (95% CI, 5% to 16%). On multivariable analysis (MVA), pre-existing cardiac disease (hazard ratio [HR], 2.96; 95% CI, 1.07 to 8.21; P = .04) and mean heart dose (HR, 1.07/Gy; 95% CI, 1.02 to 1.13/Gy; P = .01) were significantly associated with grade ≥ 3 cardiac events. Analyzed as time-dependent variables on MVA analysis, both disease progression (HR, 2.15; 95% CI, 1.54 to 3.00) and grade ≥ 3 cardiac events (HR, 1.76; 95% CI, 1.04 to 2.99) were associated with decreased overall survival. However, disease progression (n = 71) was more common than grade ≥ 3 cardiac events (n = 19).

Conclusion

The 24-month cumulative incidence of grade ≥ 3 cardiac events exceeded 10% among patients with locally advanced NSCLC treated with definitive radiation. Pre-existing cardiac disease and higher mean heart dose were significantly associated with higher cardiac event rates. Caution should be used with cardiac dose to minimize risk of radiation-associated injury. However, cardiac risks should be balanced against tumor control, given the unfavorable prognosis associated with disease progression.
Inhaled Sedation in Patients With Acute Respiratory Distress Syndrome Undergoing Extracorporeal Membrane Oxygenation
Authors: Meiser Andreas , Bomberg Hagen , Lepper Philipp M. , Trudzinski Franziska C. , Volk Thomas , Groesdonk Heinrich V.
Published: March 2017

Six patients suffering from acute respiratory distress syndrome with the need for extracorporeal membrane oxygenation (ECMO) therapy in deep sedation were included. Isoflurane sedation with the AnaConDa system was initiated within 24 hours after initiation of ECMO therapy and resulted in a satisfactory sedation (Richmond Agitation-Sedation Scale −4 to −5). Despite deep sedation, spontaneous breathing was possible in 6 of 6 patients. We observed a reduced need for vasopressor therapy and improved lung function (Pao
2, Paco
2, delta P, and tidal volume) during isoflurane sedation. Opioid consumption could be reduced, and only very low doses of isoflurane were needed (1–3 mL/h). This small case series supports the feasibility of sedation using inhaled anesthetics concurrently with venovenous ECMO.
ИММУНОТРОПНАЯ ТЕРАПИЯ В ЛЕЧЕНИИ РЕЦИДИВИРУЮЩЕГО РИНОСИНУСИТА
Authors: Stagnieva Irina Veniaminovna
Published: March 2017

Рецидивирующие риносинуситы протекают на фоне иммунодефицитных состояний, латентно, длительно, без болевого симптома.Цель. Определение показаний к назначению иммунотропной терапии у больных с рецидивирующим риносинуситом.Материалы и методы. Обследовано 85 больных с гнойным рецидивирующим риносинуситом без болевого симптома. Всем больным проведено полное клиническое обследование, иммунограмма, определение уровня IL-1β, IL-4, IL-6, IL-8, IL-10, TNFα, INFγ и субстанции Р (SP) в сыворотке крови. Для коррекции иммунной недостаточности в стандартную схему лечения гнойного риносинусита у части больных с уровнем SP<100 пг/мл (n=30) с первого дня включили иммуномодулирующий препарат. Контрольная группа (n=24) пролечена по стандартной схеме – без иммуномодулятора.Результаты. У больных с уровнем SP более100 пг/мл изменения показателей иммунограммы были характерны для нормального иммунного ответа на бактериальный антиген. Цитокиновый баланс смещен в сторону противовоспалительных цитокинов, достоверно увеличены концентрации IL-4 и IL-10. У больных с уровнем SP менее100 пг/мл показатели иммунограммы выявили иммунодефицит. Цитокиновый баланс смещен в сторону противовоспалительных цитокинов, концентрации провоспалительных цитокинов резко снижены. Включение в схему лечения иммуномодулятора позволило сократить сроки лечения на 3–4 дня.Выводы. Отсутствие боли при рецидивирующем риносинусите является проявлением нейро-иммунной регуляции воспалительного процесса. Показанием к назначению иммуномодулирующей терапии у больных с рецидивирующим риносинуситом может служить снижение уровня SР в сыворотке крови менее 100 пг/мл.Область применения результатов: ринология, клиническая иммунология.
Interdisciplinary Decisions Application in Management, or How to Use the Experience of Workload Management of Technological System with Regard to Human Resources
Authors: Сморчкова  , Smorchkova O.
Published: March 2017

To a modern executive officer enterprise management means challenging requirements in search of

unconventional solutions in system administration organization. A whole spectrum of solutions is found when

you use knowledge, traditions and managerial decisions existing in other spheres. This article contemplates

concepts and philosophy that consider the problem from the other point of view and find new or specialized

decisions from related areas. A comparison between workload management in technological system and

human resources is used as an example. Based on this comparison implications are made about certain

compatibility of these systems and possible adaptation of the existing management methods. At the end we

come to the conclusion of benefit from using intersectorial and cross-cultural experience.
Modeling of pathological processes in the experiment-the first step in translational medicine
Authors: Лепехова Светлана , Lepekhova Svetlana , Судаков Н. , Sudakov N. , Жаркая Анастасия , Zharkaya Anastasiya
Published: March 2017

The paper discusses the significance of animal experiments and modeling of pathological processes for pre-clinical drug trials, methods of diagnostics and treatment, which correspond to the concept of the first phase of the study in translational medicine. The article provides information on the methodology, legal framework and applications of experimental surgery. The simulation results of dyslipidemia and hypoparathyroidism are given. Simulation of pathology in small laboratory animals is regarded as an integral component of basic and applied biomedical research.
Association of polymorphisms Gene CYP2C19 with endpoints of efficacy and safety of clopidogrel therapy And platelet aggregation in patients with acutecoronary syndrome study Protocol
Authors: Лифшиц Г. , Lifshic G. , Зеленкская Е. , Zelenkskaya E. , Сараева Н. , Saraeva N. , Горохова Анна , Gorokhova Anna , Апарцин Константин , Apartsin Konstantin
Published: March 2017

Aim: to reveal the association of gene CYP2C19 polymorphisms and efficacy and safety endpoints of clopidogrel therapy in patients with acute coronary syndrome. Materials and methods. A total of 431 patients with acute coronary syndrome undergoing coronary stent placement was studied. CYP2C19 polymorphisms (*2, *3, *17) were evaluated, platelet aggregation with ADP and efficacy and safety for 30 days after coronary stent placement was studied. Results. Within the selected patients there was no significant association between carriage of at least one allele of the CYP2C19*2, and/or CYP2C19*3 and paradoxical response to clopidogrel. Significant association between carriage of allele CYP2C19*17 and the presence of bleeding was detected. The algorithm for selection of individual drug therapy for patients receiving clopidogrel therapy was developed. Conclusion. The results can be extremely important for decision-making about the strategy of dual antiplatelet therapy and the tactics of choice of drugs.
Department of Biomedical Research and Technologies of the Irkutsk Scientific Center of the SBRA Sprerequisites for the creation and direction of work from the editor
Authors: Белоусова С. , Belousova S.
Published: March 2017

The article presents the analysis of depopulation processes of the Russian Federation on the example of the Irkutsk region. The author evaluates the strategy of the health care system in Russia in solution of depopulation problems. Types and features of depopulation process in Russia are established. The situation of demographic processes in the Irkutsk region is described. The region is considered, as the analysis has shown, to be a typical model of depopulation processes in Russia. The paper presents the analysis of present-day measures taken for the development of health care system. It is revealed that without regard to the state and mechanisms of public health functioning, the effectiveness of presented measures on improvement of health care system is limited.
Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry
Authors: Carlier Jeremy , Diao Xingxing , Scheidweiler Karl B , Huestis Marilyn A
Published: March 2017

BACKGROUND

ADB-PINACA and its 5-fluoropentyl analog 5F-ADB-PINACA are among the most potent synthetic cannabinoids tested to date, with several severe intoxication cases. ADB-PINACA and 5F-ADB-PINACA have a different legal status, depending on the country. Synthetic cannabinoid metabolites predominate in urine, making detection of specific metabolites the most reliable way for proving intake in clinical and forensic specimens. However, there are currently no data on ADB-PINACA and 5F-PINACA metabolism. The substitution of a single fluorine atom distinguishes the 2 molecules, which may share common major metabolites. For some legal applications, distinguishing between ADB-PINACA and 5F-PINACA intake is critical. For this reason, we determined the human metabolic fate of the 2 analogs.

METHODS

ADB-PINACA and 5F-PINACA were incubated for 3 h with pooled cryopreserved human hepatocytes, followed by liquid chromatography—high-resolution mass spectrometry analysis. Data were processed with Compound Discoverer.

RESULTS

We identified 19 and 12 major ADB-PINACA and 5F-ADB-PINACA metabolites, respectively. Major metabolic reactions included pentyl hydroxylation, hydroxylation followed by oxidation (ketone formation), and glucuronidation of ADB-PINACA, and oxidative defluorination followed by carboxylation of 5F-ADB-PINACA.

CONCLUSIONS

We recommend ADB-PINACA ketopentyl and hydroxypentyl, and ADB-PINACA 5-hydroxypentyl and pentanoic acid, as optimal markers for ADB-PINACA and 5F-ADB-PINACA intake, respectively. Since the 2 compounds present positional isomers as the primary metabolites, monitoring unique product ions and optimized chromatographic conditions are required for a clear distinction between ADB-PINACA and 5F-ADB-PINACA intake.
Satires of fashionable clothing and literature in nineteenth-century Russia
Authors: McQuillen Colleen
Published: March 2017

In early nineteenth-century Russia the categories of fashionable clothing and fashionable literature emerged side by side, which gave critics of the corresponding industries a convenient discourse for satirizing the latter in terms of the former. The writings and drawings this article examines show that the enmeshment of these two feminine economies endured for decades as a productive trope despite changes in the gendering of the garment industry around mid-century. Just as Roland Barthes asserted the legibility of fashion as a semiotic system, this study treats verbal and visual representations of clothing as legible texts that are open to interpretation. It also probes the problematic relationship among body, text and clothing in representations where the clothing is not worn on the body but rather becomes a body through the literary device of personification.
‘Retaining their bestial character’: Fashion, fear of degeneration and animal protection in late imperial Russia
Authors: Gusarova Ksenia
Published: March 2017

This article examines the possible roots of the change in cultural attitudes, due to which fashionable objects of animal origin started to be viewed negatively in Russian fashion periodicals and advice manuals of the early twentieth century. Among these influences, we may count the development of the animal protection movement, with the Russian Society for the Protection of Animals established in 1865. Although initially this association was not concerned with fashion, it shaped the notion of the cruel treatment of animals, drawing public attention to this issue. An analysis of non-fiction writing by Fyodor Dostoevsky and Vikentii Veresaev will show that, while the Society’s agenda was ambiguous and met with a mixed response, the new sensibilities this group promoted were increasingly internalized by the educated public.

On the other hand, fashion criticism during the era argued that fashion distorts and deforms human shape by giving it animal features – that is, it assists degeneration. A reversal of evolution, in this case triggered by brutality, was similarly evoked by the proponents of animal protection. The newly perceived inappropriateness of certain fashionable objects was thus due to the double ‘animality’ they were believed to impart to the wearer: that of following the ‘fashion instinct’ and that of being complicit in violence.
Dancing through myself: Memory, identity, spirituality
Authors: Sellers-Young Barbara
Published: March 2017

Influenced by the rhetorical critique of post-structuralism and the additions of such new styles of ethnographic research as sensory ethnography, there has been an increased interest in autoethnography, which has been ultimately influenced by the new research in the area of neuroscience with specific reference to embodiment. This article follows my reflections from those on ethnography to contemplation of the neuroscience of embodiment, and finally the autoethnographic project focused on embodying the spiritual.
Backstage with Loïc Prigent: Documenting process from Gaultier to Chanel
Authors: Rees-Roberts Nick
Published: March 2017

Seen as the leading contemporary maker of behind-the-scenes documentaries about the world of fashion, French journalist Loïc Prigent has established a career from delving into the methods and processes involved in fabricating designer fashion. His popular television series Le Jour d’avant (The Day Before) (Prigent, 2009–10) mixes traditional information and observation with a more performative and selfreflexive mode with ironic nods to factual entertainment formats and reality television. This article unpacks Prigent’s documentary method underlining his sociological precision and particular interest in the creative process through analysis of his filmed portrait of Jean-Paul Gaultier at work recreating and contextualizing his most famous designs in front of the camera. The article concludes by critiquing Prigent’s possible collusion with the luxury mega-brands arguing that his work illustrates the precarious position of the documentarian working in global fashion in the twentyfirst century, torn between a journalistic ethic of information and the lucrative lure of covert promotion.
Bedknobs and Broomsticks: The magical manipulation of dress and the heritage object in the service of wartime fantasy
Authors: Marston Kendra
Published: March 2017

This article explores how Disney provides a utopian response to the horror and corporeal trauma of warfare through the family musical Bedknobs and Broomsticks (Stevenson, 1971), a film in which amateur sorceress Eglantine Price (Angela Lansbury) can enchant a museum’s weapons and heritage military wear into battling the Nazis in the place of ageing members from her own community. In this film, the mobilization of and attitudes towards costume and the heritage antiquity can displace human labour in wartime, so that death, destruction and bodily injury are prevented from occurring and families are brought together as opposed to being driven apart. The article ultimately argues that while human unity and the idea of multicultural harmony are celebrated, the enchanted object provides a means of cleansing political struggle in a way that disavows the human cost of warfare rather than serving to question the nature of warfare itself.
‘I thought I was like you, but I’m not’: Identity, masculinity and make-believe in Taika Waititi’s Boy (2010)
Authors: Wright Andrea
Published: March 2017

This article sets out to argue that the growing maturity of a national cinema permits a challenge to established tropes and representations that can result in innovative and original visions. Taika Waititi’s Boy (2010) is a film that deliberately confronts the conventions that have developed around the representation of Māori culture and Māori characters on-screen. By avoiding either depictions of urban violence and deprivation or mythic fantasies, the film is able to collapse notions of difference and instead focus on a transnational experience of popular culture and growing up. Furthermore, it seems to evade the weighty responsibility that often appears to restrict Indigenous cinema by embracing contradictions and fluidity. Such an approach has encouraged considerable debate amongst critics and scholars and it is the aim of this article to engage with both negative and positive responses to the film in order to contribute to the ongoing discussions. Specifically, this article will explore the film’s nostalgia for 1980s popular culture, the use of daydreams and makebelieve sequences, location, and Waititi’s approach to identity and masculinity in order to highlight its inventive and unconventional themes and style. Ultimately, the controversy and competing discourses that have emerged around the film suggest that, far from negating a sense of national, cultural identity, it has generated important reflections on the cinematic representation of Māori people and Māori culture.
Expatriate 2.0: New media for new expatriates
Authors: Mai Fan
Published: March 2017

In the aftermath of global financial crisis, a new generation of western expatriates from developed countries have chosen mainland China as their destination for temporary migration. Using case studies and in-depth interviews, this article explores how this group of transient migrants comes to define their identities as ‘new expatriates’ in China by creating their own media. From lifestyle magazines to podcasts, western expatriates are cultivating their own niche to support expatriate communities despite institutional barriers and marginalized status. This study provides insights into the motivations of creating expatriate media that connect media practices with the everyday life experiences of western expatriates in China.
Entangled belonging: Barcelona-to-Melbourne professional transient migrants
Authors: Mejía Glenda , Pink Sarah
Published: March 2017

The economic crisis in Europe has generated a context of increasing uncertainty along with new forms of globalization through a wave of migration from Europe to more thriving OECD economies, including Australia. This article examines how particular transnational senses of belonging are generated in this context through the example of how Catalan migrants generate what we refer to as an ‘entangled sense of belonging’ between Melbourne and Barcelona. In doing so, we draw on semi-structured interviews and photographic research methods undertaken with such migrants living in Melbourne. We argue that the transient nature of migration becomes contingent in this context. As such, it is not a measurable state or status, but something more qualitative and experiential, and therefore needs to be attended to through an approach that accounts for this.
UNIDADES DE CONSERVAÇÃO E SUSTENTABILIDADE: Plano de manejo e aplicação da capacidade de carga no Parque Nacional da Lagoa do Peixe (RS)
Authors: Minohara Rodrigo Hakira , Dazzi Rudinei Scaranto , Santos Alessandra Santos dos
Published: March 2017

É crescente a busca do homem pelo contato com o meio ambiente, sobre tudo por meio do turismo. Na década de 1960, houve uma mobilização mundial focada na preservação da natureza e o Brasil seguindo o exemplo, começou a estruturar políticas que garantissem a preservação dos seus ecossistemas. Esse processo acarretou na criação do Sistema Nacional de Unidades de Conservação (SNUC), que veio a regulamentar a visitação desses espaços e a sustentabilidade dos ambientes naturais, por meio de planos de manejo e da adoção de modelos de gestão que respeitem sua capacidade de carga. Considerando tais pressupostos, este artigo visa a composição de uma análise tendo como base o planejamento adotado pela Unidade de Conservação - Parque Nacional da Lagoa do Peixe (RS), local onde foram tratadas as questões de manejo e de capacidade de carga para viabilizar o recebimento de visitantes e da promoção da sensibilização para a conservação da biodiversidade. Para desenvolvimento de estudos posteriores, fica a sugestão de realização de pesquisa que englobe todos os parques pertencentes à Região Sul do Brasil, para um possível comparativo em relação ao uso público e à atividade turística. Palavras-chave: Turismo. Unidades de Conservação. Plano de Manejo.
PROGRAM JAM WAJIB BELAJAR DALAM MEMBENTUK CIVIC DISPOSITION WARGA NEGARA
Authors: Mufidah Nastiti
Published: March 2017

The purpose of this research to analyze the formation of civic disposition through compulsory Hours Learning Program, as well as knowing the character of the citizens who were able to form through the Compulsory program clock. Informants in this research is a community in Mojokerto city. Qualitative approach with case study method used in this study. Furthermore, the data collection techniques used interviews, observations and questionnaires. The results in this study indicate that the Compulsory Education Program Hours proven capable of forming civic disposition citizens. Civic disposition can be formed based on the results of this study the character of discipline and care, while other characters such as responsibility and tolerance still can’t set up perfectly.
The Dynamic Response of Brittle Materials under Impact Loading
Authors: Zheng Zhijia , Wang Enzhi , Liu Xiaoli , Duan Zhuoping , Zhang Liansheng , Ou Zhuocheng , Zhong Jianwen
Published: March 2017

In order to make sense of the dynamic response of brittle materials under the certain range of impact strength, the numerical simulation for two kinds of representative ones glass and ceramic are conducted, in which the elastic micro-crack damage model is used. The plane impact experiments of ceramic and glass are summarized, which are used to compare with the simulation results. The simulation results show that the dynamic responses of brittle materials, failure wave and the plastic-like response appeared in glass and ceramic respectively are depended on their micro-cracks distribution in meso-scale. And moreover, both of failure wave and the plastic-like response are controlled by the same mechanism, and the different phenomena are just influenced by the size and distribution of the micro-cracks.
Source conditions and accuracy estimates in Tikhonov’s scheme of solving ill-posed nonconvex optimization problems
Authors: Kokurin Mikhail Y.
Published: March 2017

We obtain rate of convergence estimates for approximations delivered by Tikhonov’s scheme of solving ill-posed nonconvex optimization problems in a Hilbert space.
The problems under investigation involve minimization of twice Frechet differentiable functionals given with errors on a closed convex set having a nonempty interior and smooth boundary.
Assuming that the desired solution satisfies an appropriate source condition which includes the second derivative of the cost functional and depends on the geometry of constraints near the solution, we establish accuracy estimates in terms of the error level. Both the a priori and a posteriori parameter choice rules are analyzed.
Giant parathyroid adenoma associated with severe hypercalcemia in an adolescent patient
Authors: Kartal Kinyas , Aygun Nurcihan , Bankaoglu Mujdat , Ozel Alper , Uludag Mehmet
Published: March 2017

Background:

The objective of this study is to bring attention to the importance of differential diagnosis in adolescent patients with skeletal involvement and hypercalcemia.

Case:

A 17-year-old male patient with a complaint of severe leg pain was admitted to our hospital. Seven months before he had a fracture of his distal humerus after falling on to his left shoulder and was treated conservatively. Five months previously, he had a rupture of his quadriceps tendon. Magnetic resonance imaging (MRI) was performed for the quadriceps tendon rupture and was evaluated as polyostotic fibrous dysplasia (PFD). Doctors decided to operate for the ruptured tendon but they detected severe hypercalcemia in the pre-operative blood tests and noticed that the main disease was primary hyper-parathyroidisim (PHPT) which was caused by a giant parathyroid adenoma.

Conclusions

Giant parathyroid adenoma can present in adolescent patients with multiple bone lesions and severe hypercalcemia. PHPT should be considered in the differential diagnosis of pathological bone fractures and benign bone tumors in every age. This may prevent patients from miss or delayed diagnosis of PHPT.
On the libration collinear points in the restricted three – body problem
Authors: Alzahrani F. , Abouelmagd Elbaz I. , Guirao Juan L.G. , Hobiny A.
Published: March 2017

In the restricted problem of three bodies when the primaries are triaxial rigid bodies, the necessary and sufficient conditions to find the locations of the three libration collinear points are stated. In addition, the Linear stability of these points is studied for the case of the Euler angles of rotational motion being θ

i
= 0, ψi
+ φi
= π/2, i = 1, 2 accordingly. We underline that the model studied in this paper has special importance in space dynamics when the third body moves in gravitational fields of planetary systems and particularly in a Jupiter model or a problem including an irregular asteroid.
An investigation into the structure and morphology of polyamide 6/polyaniline hybrid fibers
Authors: Zarrini Kamran , Youssefi Mostafa
Published: March 2017

A wet spinning dope composition for the production of hybrid fibers was selected based on the analysis of a ternary phase diagram of polyamide 6 (PA6)/formic acid/water. Polyaniline was later added to this dope with different weight percentages to produce hybrid fibers. The results showed that polyaniline was dispersed uniformly in the PA6 matrix and the spinning dope composition had a great impact on the morphology of the hybrid fibers produced with different quantities of polyaniline. The electrical conductivity of the hybrid fibers was increased with the increase in polyaniline content of the fibers and reached 7.94×10−3 S·cm−1 for the sample that contained 30% polyaniline. The crystalline structure of PA6 in all hybrid fibers was revealed to be only of α form. No other crystalline forms, for example β form, was observed in PA6 due to the presence of polyaniline in the system as revealed from x-ray diffraction results.
Hemodynamic and Cardiorespiratory Predictors of Sport Rock Climbing Performance
Authors: Fryer Simon M. , Giles David , Palomino Inmaculada Garrido , de la O Puerta Alejandro , España-Romero Vanesa
Published: March 2017

Fryer, SM, Giles, D, Garrido Palomino, I, de la O Puerta, A, and España-Romero, V. Hemodynamic and cardiorespiratory predictors of sport rock climbing performance.J Strength Cond Res32(12): 3543–3550, 2018—Rock climbing performance has been suggested to involve a notable contribution from aerobic metabolism. Previously, it has been shown that forearm oxygenation kinetics can be used to distinguish ability groups and predict red-point sport climbing performance. Currently, it is not known if forearm oxygenation kinetics or a sport-specific assessment of cardiorespiratory fitness best predicts sport rock climbing performance. The aim of the study was to determine whether forearm oxidative capacity index, maximal deoxygenation (Δ score) during a treadwall JOURNAL/jscr/04.03/00124278-201812000-00029/29FFU1/v/2023-08-19T002809Z/r/image-tiff peak test, treadwall JOURNAL/jscr/04.03/00124278-201812000-00029/29FFU1/v/2023-08-19T002809Z/r/image-tiff peak, or running JOURNAL/jscr/04.03/00124278-201812000-00029/29FFU1/v/2023-08-19T002809Z/r/image-tiff max best predicts self-reported sport climbing performance. Twenty-one male sport rock climbers completed a treadwall JOURNAL/jscr/04.03/00124278-201812000-00029/29FFU1/v/2023-08-19T002809Z/r/image-tiff peak, running JOURNAL/jscr/04.03/00124278-201812000-00029/29FFU1/v/2023-08-19T002809Z/r/image-tiff max, and an assessment of near-infrared spectroscopy–derived oxidative capacity index. Linear regression, adjusted for age and experience (years), revealed that forearm oxidative capacity index, treadwall maximal deoxygenation (Δ), and treadwall JOURNAL/jscr/04.03/00124278-201812000-00029/29FFU1/v/2023-08-19T002809Z/r/image-tiff peak all significantly predicted self-reported red-point sport climbing ability (AdjR2= −0.398, −0.255, and 0.374, respectively), whereas treadmill running JOURNAL/jscr/04.03/00124278-201812000-00029/29FFU1/v/2023-08-19T002809Z/r/image-tiff max did not (AdjR2= −0.052). Additionally, multiple regression suggested that the combined significant aerobic predictors accounted for 67% of the variance in red-point climbing ability. Findings suggest that training for sport rock climbing performance should look to incorporate modalities that focus on (a) improving local forearm aerobic capacity and (b) improving whole-body aerobic capacity using sport-specific apparatus, such as treadwalls.
Effect of Ankle Mobility and Segment Ratios on Trunk Lean in the Barbell Back Squat
Authors: Fuglsang Emil I. , Telling Anders S. , Sørensen Henrik
Published: March 2017

Fuglsang, EI, Telling, AS, and Sørensen, H. Effect of ankle mobility and segment ratios on trunk lean in the barbell back squat. J Strength Cond Res 31(11): 3024–3033, 2017—The barbell back squat is a popular exercise used for both performance enhancing and rehabilitation purposes. However, injuries are common, and people with a history of lower back pain are especially vulnerable. Past studies have shown that higher trunk angles (less forward lean) generate less stress on the lower back; thus, it seems appropriate to investigate the factors presumed to influence the trunk angle. Therefore, the aim of this study was to investigate how ankle mobility and the segment ratios between the thoracic spine, thighs, and shanks influence the trunk angle in the back squat. While recorded with motion capture, 11 male subjects performed 3 repetitions at approximately 75% of 1 repetition maximum in the squat to a parallel position (thighs horizontal) or lower. Furthermore, subjects performed a weight bearing lunge test to determine maximal range of motion (ROM) of the ankle joint. Segment angles of the shank, thigh, and trunk segments as well as ankle joint angles were calculated by 2-dimensional kinematic analysis. Simple linear and multiple regressions were used to test the correlation between the lower extremity angles, segment ratios, and the trunk angle. On average, subjects had an 11.4 ± 4.4° deficit in dorsiflexion ROM between maximal ROM and ROM in the parallel squat (PS) which was independent of maximal ROM. Ankle mobility showed to significantly negatively correlate with trunk angle, thereby showing that a subject with greater ankle ROM had a more upright torso in the PS position. This study was unable to find a significant correlation between the segment ratios and trunk angle. Furthermore, when combined, no significant relationship between ankle mobility, segment length ratios, and trunk angle were found, although it was noticed that this more complex model showed the greatest R
2 value.
Hyperinsulinaemic hypoglycaemia, renal Fanconi syndrome and liver disease due to a mutation in the HNF4A gene
Authors: Clemente María , Vargas Alejandro , Ariceta Gema , Martínez Rosa , Campos Ariadna , Yeste Diego
Published: March 2017

HNF4A gene mutations have been reported in cases of transient and persistent hyperinsulinaemic hypoglycaemia of infancy (HHI), particularly in families with adulthood diabetes. The case of a patient with HHI, liver impairment and renal tubulopathy due to a mutation in HNF4A is reported.

Learning points:

Urine specimen study in cases of HHI with diazoxide response is necessary to rule out specific metabolic conditions (l-3-hydroxyacyl-coenzyme A dehydrogenase deficiency) or tubular renal involvement.

Hyperinsulinaemic hypoglycaemia due to the heterozygous mutation (p.Arg63Trp, c. 187C > T) in the HNF4A gene is associated with renal tubulopathy and liver involvement.

Follow-up of patients diagnosed of HHI is mandatory to detect associated conditions.
Simultaneous assay of cortisol and dexamethasone improved diagnostic accuracy of the dexamethasone suppression test
Authors: Ueland Grethe Å , Methlie Paal , Kellmann Ralf , Bjørgaas Marit , Åsvold Bjørn O , Thorstensen Ketil , Kelp Oskar , Thordarson Hrafnkell B , Mellgren Gunnar , Løvås Kristian , Husebye Eystein S
Published: March 2017

Objectives

The overnight dexamethasone (DXM) suppression test (DST) has high sensitivity, but moderate specificity, for diagnosing hypercortisolism. We have evaluated if simultaneous measurement of S-DXM may correct for variable DXM bioavailability and increase the diagnostic performance of DST, and if saliva (sa) is a feasible adjunct or alternative to serum.

Design and methods

Prospective study of DST was carried out in patients with suspected Cushing’s syndrome (CS) (n = 49), incidentaloma (n = 152) and healthy controls (n = 101). Cortisol, cortisone and DXM were assayed by liquid chromatography–tandem mass spectrometry (LC–MS/MS).

Results

Three hundred and two subjects underwent DST; S-cortisol was ≥50 nmol/L in 83 patients, of whom 11 had CS and 27 had autonomous cortisol secretion. The lower 2.5 percentile of S-DXM in subjects with negative DST (n = 208) was 3.3 nmol/L, which was selected as the DXM cut-off level. Nine patients had the combination of low S-DXM and positive DST. Of these, three had been misdiagnosed as having autonomous cortisol secretion. DST results were highly reproducible and confirmed in a replication cohort (n = 58). Patients with overt CS had significantly elevated post-DST sa-cortisol and sa-cortisone levels compared with controls; 23 of 25 with autonomous cortisol secretion had elevated sa-cortisone and 14 had elevated sa-cortisol.

Conclusions

Simultaneous measurement of serum DXM and cortisol reduced false-positive DSTs by 20% and improved the specificity. S-DXM >3.3 nmol/L is sufficient for the suppression of cortisol <50 nmol/L. Measurement of glucocorticoids in saliva is a non-invasive and easy procedure and post-DST sa-cortisone was found particularly useful in the diagnosis of CS.
ALEITAMENTO NATURAL EM CRECHES: AVALIAÇÃO DAS OPORTUNIDADES DAS MÃES PARA AMAMENTAR SEUS FILHOS
Authors: Rezende Magda Andrade
Published: March 2017

A proposta deste trabalho consiste em conhecer e analisar como está se dando o aleitamento natural em duas creches governamentais da cidade de São Paulo. O assunto foi escolhido tendo em vista sua importância para criança e mãe, pois é uma oportunidade para o estabelecimento e fortalecimento de vínculos afetivos entre a dupla. Este fato por si só justificaria seu estudo. No entanto além disso o leite humano acarreta para a criança em benefícios de ordem regulatória (através de hormônios), nutricional, anti-infecciosa e anti-alérgica. Estes fatos tem sido bastante explorados nos últimos anos pela literatura das áreas de saúde e biológica, em geral, além da social. Este último enfoque se justifica uma vez que a nutriz que trabalha pode encontrar dificuldades (ou não) para amamentar seus filhos. Neste ponto a abordagem também interessa às enfermeiras-pediatras, uma vez que gerenciamento e assessoria técnica a equipamentos de guarda de criança são também suas funções. Neste trabalho se pretende estudar o que é considerado adequado para lactentes e suas mães (a amamentação), no contexto (creches) em que atualmente se encontra uma parcela das mulheres brasileiras na cidade de São Paulo.
INCONTINÊNCIA URINÁRIA NO IDOSO: ASSISTÊNCIA DE ENFERMAGEM
Authors: Rodrigues Rosalina Aparecida Partezani , Zago Márcia Maria Fontão
Published: March 2017

Causas e tipos de incontinência urinária do idoso são revistas. A enfermeira tem um papel fundamental na assistência de enfermagem visando à deteção, avaliação e orientação do problema do idoso incontinente, contribuindo de maneira relevante para promover a continência da população idosa que vive na comunidade.
A POLÍTICA DE REPRODUÇÃO BIOLÓGICA HUMANA NO BRASIL
Authors: Oliveira Maria Amélia de Campos
Published: March 2017

A autora recupera alguns dos determinantes históricos da política de reprodução humana no Brasil, situando-a no conjunto das políticas sociais. Argumenta que a reprodução biológica não é a única a condicionar o perfil reprodutivo das classes, sendo necessário considerar ainda a reprodução da força de trabalho, dada pelas formas de trabalho e consumo em cada classe social.
SPATIALIZATION OF SOIL CHEMICAL AND PHYSICAL ATTRIBUTES IN AN AGROFORESTRY SYSTEM, SEROPÉDICA, BRAZIL
Authors: Silva Camila Santos da , Pereira Marcos Gervasio , Delgado Rafael Coll , Silva Eduardo Vinícius da
Published: March 2017

ABSTRACT The purpose of this study was to spatialize the chemical and physical attributes of the soil in an agroforestry system in Seropédica, Rio de Janeiro, Brazil. Thirty-one soil samples were collected from 0-10 cm, 10-20 cm, and 20-40 cm depths, and each sampling point was georeferenced. The pH (in H2O), potential acidity (H+Al), calcium (Ca+2), magnesium (Mg+2), aluminum (Al+3), sodium (Na+), potassium (K+), phosphorus (P), organic carbon (C), cation exchange capacity of the soil (T value), base saturation (V value), total clay, total sand, silt, and density of fine roots were measured. The software ArcGIS 10.2 was used to perform the semivariogram analysis and the fitting of the models, and spatial interpolation was performed using a first-order trend ordinary kriging process with spherical, exponential, and Gaussian spatial models. Based on the results, only the exponential and Gaussian models were fitted to the variables, except for the Mg2+ and V value variables, which presented no spatial dependence, thus showing a pure nugget effect (PNE). Distribution maps were generated for the variables (except for those exhibiting PNE), which showed correlation between the variables pH and Al3+, organic carbon and cations, phosphorus and total clay, and silt and sand. Overall, geostatistics could be applied to spatialize the chemical and physical attributes of the soil in the agroforestry system, except in the case of Mg2+ and the V value.
CURVATURA DA SUPERFÍCIE E SEU EFEITO NA VARIABILIDADE ESPACIAL DOS ATRIBUTOS DO SOLO, PINHEIRAL - RJ / BR
Authors: Santos Gilsonley Lopes dos , Pereira Marcos Gervasio , Lima Sandra Santana de , Ceddia Marcos Bacis , Mendonça Victória Maria Monteiro , Delgado Rafael Coll
Published: March 2017

RESUMO Compreender a variabilidade espacial dos atributos químicos e físicos do solo é importante para melhorar as práticas de manejo e conservação do solo. Por sua vez, a variabilidade espacial das propriedades do solo resulta da variação das características morfológicas do relevo. Assim, o objetivo deste estudo foi avaliar a influência da curvatura da superfície na variabilidade espacial dos atributos químicos e físicos do solo na região de Mar de Morros (Pinheiral-Rio de Janeiro, Brasil). Foram selecionadas duas pedoformas adjacentes com curvatura convexa e côncava e coletadas amostras de solo em uma grade com espaçamento fixo de 10 metros entre os pontos. Foram coletadas um total de 56 amostras de solo (0-5 cm de profundidade) nas duas pedoformas e analisados os atributos físicos e químicos do solo. Na análise dos dados foi utilizada estatística descritiva e geoestatísitca. Os atributos químicos do solo apresentaram um padrão aleatório quanto a distribuição espacial em ambas as pedoformas. No entanto, a pedoforma côncava apresentou maiores valores de pH e potássio e valores mais baixos para alumínio quando comparada a pedoforma convexa. Por outro lado, os valores de silte apresentaram dependência espacial em ambas às pedoformas. Já a densidade do solo e o teor de argila apresentaram dependência espacial na pedoforma convexa. Os valores da densidade do solo e silte aumentaram no sentido do terço superior para o terço inferior em ambas as pedoformas. Os resultados mostram que para esta área de estudo, a curvatura da superfície tem maior influência na dependência espacial dos atributos físicos do que para os atributos químicos solo.
PULP PRODUCED WITH WOOD FROM Eucalyptus TREES DAMAGED BY WIND
Authors: Zanuncio Antonio Jose Vinha , Carvalho Amélia Guimarães , Carneiro Angelica de Cassia Oliveira , Damasio Renato Augusto Pereira , Valenzuela Paulina , Gacitúa William , Colodette Jorge Luiz
Published: March 2017

ABSTRACT Wind may damage eucalyptus trees, especially 24 months after planting, which can reduce wood fiber quality and hinder pulp production. The objective of this study was to evaluate the use of these materials in mixtures with wood from seven-year-old trees to produce pulp. Bleached pulp was produced using 100, 95, 85, 75 and 0% wood from seven-year-old eucalyptus trees, related to cutting age. Wood from two-year-old trees, when trees are most susceptible to damage by wind, completed each treatment. A 5 cm thick disc was taken from breast height (1.3m) on each tree for anatomical and ultrastructural characterization. The seven-year-old wood had lower vessel frequency and fibers with a longer length, higher cell wall fraction, higher modulus of elasticity and hardness, and a lower microfibril angle. Pulp refining decreased the opacity and specific volume, increased air resistance and improved mechanical properties. The addition of two-year-old wood to produce pulp reduced the mechanical properties and opacity, and increased the air resistance of the paper. The proportion of two-year-old wood that can be used in pulp production varied with the clone, parameter, and refining level. However, the pulp produced with 5% wood from two-year-old trees and 95% wood from seven-year-old trees was similar to that with 100% seven-year-old wood. Therefore, 5% two-year-old wood can be used to produce pulp without quality losses.
COMPLEXO ENZIMÁTICO E FARELO DE ARROZ INTEGRAL SOBRE O DESEMPENHO PRODUTIVO E QUALIDADE DOS OVOS DE POEDEIRAS EM SEGUNDO CICLO DE PRODUÇÃO
Authors: Santos Verônica Lisboa , Gentilini Fabiane Pereira , Ladeira Sílvia Regina Leal , Anciuti Marcos Antonio , Rutz Fernando
Published: March 2017

Resumo Objetivou-se avaliar o desempenho produtivo e a qualidade dos ovos de aves que receberam dietas contendo farelo de arroz integral (FAI), com ou sem adição de complexo enzimático (CE), com e sem valorização energética. Foram utilizadas 480 poedeiras Hisex brown, durante 112 dias experimentais, divididas em oito tratamentos com 12 repetições cada. Os tratamentos 1, 2, 3 e 4 consistiram da presença de milho (M) e farelo de soja (FS), e os tratamentos 5, 6, 7 e 8 consistiram de M, FS e 20% de FAI, com ou sem inclusão do CE. Os tratamentos 1, 3, 5 e 7 não receberam CE; no entanto, nos tratamentos 3 e 7 houve valorização energética de 100 kcal EM/kg (controles negativos). O CE quando presente foi acrescido sem valorização energética (on top) nos tratamentos 2 e 6, e valorizado em 100 kcal EM/kg nos tratamentos 4 e 8. Aves que receberam FAI produziram ovos e claras mais pesadas, gemas menos pigmentadas e apresentaram maior peso vivo. Aves que consumiram FAI recebendo CE on top ou sem valorização apresentaram maior consumo de ração. Maior unidade Haugh e melhor conversão alimentar por dúzia foram observados em aves que receberam tratamento controle ou controle com CE valorizado.
HEMATOLOGICAL PARAMETERS AND SEROPREVALENCE OF Ehrlichia canis AND Babesia vogeli IN DOGS
Authors: Fonseca Juliana Pierangeli , Bruhn Fábio Raphael Pascoti , Ribeiro Manoel Junqueira Maciel , Hirsch Christian , Rocha Christiane Maria Barcelos Magalhães , Guedes Elizângela , Guimarães Antônio Marcos
Published: March 2017

Abstract The aim of this study was to determine the prevalence of anti-Ehrlichia canis and anti-Babesia vogeli IgG antibodies in dogs and correlate this prevalence with risk factors to evaluate the relation of serological status to hematological findings. Blood samples of dogs attended from September 2011 to March 2012 at the veterinary hospital of the Federal University of Lavras, Brazil, were analyzed using an indirect fluorescence antibody test (IFAT). Of the total 160 dog serum samples, 23.7% (38 dogs; CI95 17.7% - 30.7%) were seropositive for E. canis, 40.0% (64 dogs; CI95 40.0% - 59.2%) for B. vogeli, and 5.6% (9 dogs) for both hemoparasites. None of the epidemiological variables showed a significant association (P>0.05) with seropositivity to E. canis and B. vogeli. Dogs seropositive for E. canis showed lower values for hematocrit (P<0.05). However, for the erythrogram, the platelet count, the leukogram and clinical signs, no significant difference (P>0.05) was observed between dogs that were seropositive and seronegative for E. canis or for B. vogeli. Serological results suggest that infection with E. canis and B. vogeli is endemic in the canine population in question, with a prevalence of the subclinical phase (asymptomatic) in dogs that are seropositive for ehrlichiosis or babesiosis.
Nesting of Morelet’s crocodile, Crocodylus moreletii (Dumeril and Bibron), in Los Tuxtlas, Mexico
Authors: Villegas A. , Mendoza G. D. , Arcos-García J. L. , Reynoso V. H.
Published: March 2017

Abstract We evaluated the nesting by Crocodylus moreletii in Lago de Catemaco, Veracruz, southeastern, Mexico. During the nesting and hatching seasons, we searched for nests along the northern margins of the lake and small associated streams. We investigated egg mortality by weekly monitoring each of the nests found, recording sign of predation (tracks and holes dug into the nest) and the effect of water level fluctuations. We not found differences to nest between inland or flooded zones. However, we found that egg size varied among nests. In nests built inland, predation was the major cause of egg mortality whereas flooding resulted in more deaths of eggs in the flooding zone. Flooding killed 25% of eggs monitored in this study. We suggest that to increase nest success in the Morelet’s crocodile it is necessary to promote conservation of nesting areas around the lake, recently occupied by urban or tourist developments.