bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Performance of Direct Posterior Composite Restorations in Patients with Amelogenesis Imperfecta
Authors: Tekçe N , Demirci M , Sancak EI , Güder G , Tuncer S , Baydemir C
Published: October 2022

The objective of this study was to analyze and assess the clinical performance of direct composite restorations using a nanohybrid and a nanofill composite material for posterior teeth in patients with amelogenesis imperfecta (AI). This study involved 15 patients between the ages of 14 and 30 years suffering from amelogenesis imperfecta (AI). During the study, the patients received direct composite restorations using either the Clearfil Majesty ES-2 (Kuraray Medical Inc, Tokyo, Japan) and Clearfil Universal Bond (Kuraray) or Filtek Ultimate Universal Restorative (3M ESPE, St Paul, MN, USA) and Single Bond Universal Adhesive (3M ESPE). The evaluations of the restorations were conducted per the modified USPHS criteria at the time of baseline as well as during the first-, second-, third-, and fourth-year follow-up sessions. After four years, it was observed that the cumulative success rate of direct posterior restorations was 98.1% for Clearfil Majesty ES-2 and 92.2% for Filtek Ultimate. During the study one Clearfil Majesty ES-2 restoration and four Filtek Ultimate restorations failed. There was a significant difference between Clearfil Majesty ES-2 and Filtek Ultimate in the color match in posterior restorations after three and four years. The causes of failure included marginal discoloration and caries, as well as fracture of the restoration. Hence, it can be stated that the use of nanohybrid or nanofill composites in posterior direct restorations in patients with AI looks promising. The failure rate of Clearfil Majesty ES-2 was found to be lower than that of Filtek Ultimate restorations. Clinically, the rate of optimum restorations conducted for partial discoloration, marginal adaptation, color match, and surface texture were observed to be higher when Clearfil Majesty ES-2 was used. However, additional studies are needed to assess the clinical performance of direct posterior composite materials in patients with AI.
Vertical Marginal Discrepancy Performance of a CAD-CAM System with Multiple Users
Authors: Pereira STPL , Roberts HW
Published: October 2022

Purpose

The purpose of this evaluation was to evaluate the vertical marginal discrepancies of a computer-aided design-computer-aided manufacture (CAD-CAM) system used by different providers at separate time intervals.

Methods and Materials

Lithium disilicate monolithic crowns on mandibular third molars were fabricated by three different providers inexperienced in digital dentistry. Using a precision rotary stage mounted on a digital recording microscope, the crown vertical marginal discrepancy was assessed using 160× magnification at 5-degree intervals around the crown marginal circumference for a total of 72 measurements per specimen. In addition to mean vertical marginal discrepancy, the maximum vertical marginal discrepancy, and its location as well as the percent of closed marginal assessments, were assessed. Mean data was analyzed using Kruskal–Wallis and Dunn post hoc testing at a 95% level of confidence (α=0.05).

Results

The mean marginal vertical discrepancy for all specimens was 21.1 ± 5.5 μm and a significant difference (p=0.0016) existed between groups but with noted wide similarity overlap. No difference (p=0.65) was observed with the mean closed margin percentage, but a significant difference (p=0.0012) existed in the observed maximum marginal discrepancy between groups. The 2-mm axial wall height (AWH), 20-degree total occlusal convergence (TOC) had significantly less (p<0.017) mean vertical marginal discrepancies than the 4-mm AWH, 20-degree TOC, and the 3-mm AWH, 16-degree TOC groups with the remaining groups similar (p>0.147). The plotted location of the specimen’s maximum vertical discrepancy suggests a potential pattern amid the 360-degree margin circumference.

Conclusions

Under the conditions of this study, CAD-CAM-derived monolithic lithium disilicate ceramic crowns fabricated by different clinicians demonstrated mean vertical marginal discrepancy results that were less than the suggested maximum clinically acceptable values. A potential for patterns of marginal discrepancy results was identified and deserves further evaluation. Results should be interpreted with caution as in vitro methodologies vary and do not directly correlate with clinical conditions.
Optimization and design for additive manufacturing of a fuel cell end plate
Authors: Herzog Dirk , Röver Tim , Abdolov Sagynysh , Becker Florian , Gentner Christoph
Published: October 2022

Proton exchange membrane fuel cells (PEMFCs) represent today one of the most common types of fuel cells for mobility applications due to their comparatively high-power density, low operating temperature, and low costs. A PEMFC regularly consists of a stack of individual cells in which each consists of polar plates and a membrane electrode assembly. To achieve the best possible electric conductivity over the series connection of cells, the contact pressure in between the cells must be uniformly distributed over the cell area. This pressure is usually applied to the stack by end plates, which frame the stack and are clamped together by bolts, which are tightened by a defined torque. Typically, these end plates are made from bulk material with no or limited optimization. Looking at mobility applications, e.g., in aerospace, a fuel cell should ideally provide high efficiency at the lowest weight. Based on this assumption, this paper uses topology optimization varying the material as well as the design space to derive new design concepts for the end plates of a PEMFC. The designs are compared with respect to an even stress distribution to the fuel cell stack, the weight of the plates, and the manufacturability in the laser powder bed fusion process. The most promising design is manufactured and results in a weight decrease of 48% compared to previously used aluminum bulk plates. Finally, the optimized base plates are applied to a test cell and the performance is compared to their conventional counterparts, showing a 1% increase in electric stack power despite the lower mass.
Nekropolia Kochanowskich? Osiemnastowieczne pochówki w kaplicach zwoleńskiego kościoła w świetle metryk parafialnych
Authors: Kozdrach Mariusz
Published: October 2022

Późnorenesansowe grobowe kaplice kopułowe, wzniesione przy kościele w Zwoleniu w XVII w. z fundacji Kochanowskich i Owadowskich (Wołuckich), ocenia się powszechnie przez pryzmat epitafiów zachowanych w starszej z nich (św. Franciszka). Wiedza o ich funkcjonowaniu jako nekropolii jest jednak ograniczona. Na podstawie dostępnych metryk zgonów z lat 1695–1800 ustalono tożsamość oraz przybliżoną liczbę osób pogrzebanych w kryptach obu kaplic. Pozwoliło to na określenie roli i funkcji dawnych rodowych fundacji w nowych warunkach u schyłku XVIII w.
WAYS OF EXPRESSING NON-PREPOSITIONAL NOMINAL AND VERB GOVERNMENT IN RUSSIAN AND PERSIAN: A COMPARATIVE STUDY
Authors: MEKHRIZI MOKHSEN A. , AVVAL ALI M.
Published: October 2022

The relevance of the forthcoming work lies in the interest of accelerating the qualitative study of a foreign language among students of the Persian and Russian languages. The results of the article are helpful for learners of both languages, especially for native speakers of Russian, who, due to the lack of research on this topic in Persian, cannot compare the ways of expressing the grammatical governance of their native language with Persian. The objectives of this study are to identify the proximity of Russian and Persian grammars in the broad sense, to study grammatical governance and compare the ways of expressing grammatical governance in both languages.
NEURAL NETWORK PREDICTION OF EARLY ANEMIA IN EXTREMELY PREMATURE CHILDREN
Authors: YASINSKY IGOR F. , KHARLAMOVA NATALYA V. , NAZAROV SERGEY B. , SHULEPOV KIRILL A. , IVANENKOVA YULIYA A.
Published: October 2022

A current problem is the prediction of the early anemia development in newborn children. To solve this problem, an intelligent neural network system has been proposed, which, based on the criteria for anamnesis and test results, assesses the risk of developing a disease. The authors analyzed the subject area and performed a correlation assessment of the anemia development factor influence. A conceptual model of the forecasting system is proposed, input and output data are determined and a training sample is developed. The structure of the neural network is designed, including the main components of information and their weights. For training, a hybrid method is applied, which is a combination of error back-propagation algorithm, stochastic and genetic search. The hybrid combines the advantages of fast search according to the antigradient of the objective error function and the ability to overcome the local extremum due to random change of coordinates of the search point and genetic operations.
La enfermedad renal oculta en la población diabética de Copalillo, Guerrero, México
Authors: Cuevas Deloya Abrahan , Barlandas Rendón Nicolás Rogelio Eric , Hernández Nava Rocio Guadalupe , Ortiz Saldivar Emmanuel Antonio , Quintana Ponce Sandra
Published: October 2022

Las enfermedades renales presentan una alta prevalencia entre la población mexicana. En el primer semestre del 2021, ocuparon el 10.o lugar como causa de muerte en México. La enfermedad renal crónica (ERC) se asocia con una disminución de la función renal relacionada con la edad, la presencia de hipertensión, diabetes, obesidad y trastornos renales primarios. Para esta investigación, durante el año 2018, se realizó un estudio descriptivo analítico en Copalillo, Guerrero, México, con el objetivo de identificar las alteraciones bioquímicas y antropométricas que influyen en la presentación y desarrollo de la enfermedad renal oculta (ERO) y la ERC en pacientes diabéticos. Se determinaron parámetros antropométricos y bioquímicos: creatinina, glucosa, urea, colesterol, triglicéridos, albuminuria y filtrado glomerular (FG). Para la determinación del FG, se empleó la ecuación denominada CKD-EPI, basada en la utilización de creatinina estandarizada, ajustada en función de la edad, sexo y raza. Para los parámetros cuantitativos se obtuvieron los valores estadísticos de: media, desviación estándar, valor máximo y valor mínimo; para la comparación de medias, se utilizó el valor p mediante la prueba t de Student usando el software Stata v14.2. La población total del estudio estuvo constituida por 86 pacientes adultos diabéticos y 114 no diabéticos, de los cuales 71 % (142) fueron del sexo femenino y 29 % (58) del masculino. Se identificó que 45 % de los pacientes diabéticos no seguían el tratamiento para esta patología, 87 % presentaron hiperglucemia y 7 % presentaron valores elevados de creatinina. La determinación del FG por medio de la ecuación de CKD-EPI permitió identificar a 11 pacientes con enfermedad renal, de los cuales cinco tenían ERO y seis ERC, esto es, 2.5 % y 3 % de la población total, respectivamente. Además, 81 % de estos pacientes con enfermedad renal eran diabéticos. Por último, se observaron diferencias estadísticamente significativas en los parámetros de creatinina, urea, albuminuria, filtrado glomerular, presión arterial diastólica, presión arterial sistólica y la edad entre los pacientes con enfermedad renal y aquellos sin la enfermedad.
Religiosidade/Espiritualidade na atuação da Psicologia Social e Comunitária
Authors: Oliveira Ana Carolina da Silva , Gaia Ronan da Silva Parreira , Scorsolini-Comin Fabio
Published: October 2022

A partir da necessidade de explorar mais profundamente o modo como a religiosidade/espiritualidade (R/E) tem atravessado a formação em Psicologia, o presente estudo apresenta uma reflexão crítica acerca da literatura científica produzida sobre a R/E, tomando por base um relato de experiência profissional que narra a inserção de uma profissional da Psicologia em uma comunidade periférica durante o trabalho com famílias em uma cidade de médio porte do Estado de São Paulo. Este relato tem por objetivo refletir sobre como emerge a dimensão da R/E no contexto familiar e comunitário tendo como norte a Psicologia Social e Comunitária. O profissional que atua com a comunidade tem o compromisso com a promoção de direitos (humanos e sociais), com o protagonismo dos sujeitos e com a qualidade de vida para todos. Esse profissional deve acolher as diversas denominações e compreender os sentidos e significados que são atribuídos a elas pelas coletividades com as quais atua. A laicidade da prática psicológica não pode ser confundida com a negligência em torno dessa dimensão, mas sim de seu acolhimento ético, crítico e perenemente humanizador das populações atendidas.
Prática psicológica mediada por tecnologia
Authors: Fiorott Juliana Gomes , Pasin Helena Cristina Almeida Pasin , Hensel Bruna Hensel Puente , Giacomozzi Andréia Isabel , Bousfield Andréa Barbará da Silva
Published: October 2022

Os grupos reflexivos voltados à temática da adoção surgem como forma de proporcionar espaços grupais comprometidos com a elaboração das motivações e angústias que permeiam o processo adotivo. Com a chegada da pandemia da COVID-19, muitas atividades foram adaptadas para o contexto on-line e fizeram uso de tecnologias da informação, incluindo os grupos no âmbito da adoção. Assim, o presente relato de experiência se propõe a refletir sobre a potência e especificidades das intervenções grupais, considerando os desafios e possibilidades da atuação on-line, bem como delinear estratégias de condução e modos de coordenação de grupos on-line no contexto da parentalidade adotiva. Observou-se que a vivência de grupos online com pretendentes à adoção pode ser uma forma de intervenção profícua e possibilita reflexões grupais com participantes de diferentes etapas da pré-adoção, bem como integrantes de diferentes localidades. Além disso, observou-se que a modalidade on-line facilitou a participação, otimizando o tempo. Como desafios, foi relatada a dificuldade na conexão de internet e a falta de contato físico e conversa frente a frente. A partir de algumas temáticas, buscou-se proporcionar a reflexão sobre todo o projeto adotivo, desde as motivações para a adoção ao momento pós-adoção.
Representação social sobre a surdez
Authors: Guimarães Valéria Maria Azevedo , Silva Joilson Pereira da
Published: October 2022

O presente estudo teve como objetivo realizar uma revisão integrativa da literatura referente aos estudos científicos que envolvessem a representação social e a surdez. Para isso, realizou-se uma busca nas bases de dados SciELO.org, PePSIC, LILACS, PsycINFO (APA) e Scopus (Elsevier), por meio da plataforma Periódicos CAPES no mês de setembro do ano 2020. Os descritores foram: representação social, surdez, surdo e deficiente auditivo, na língua portuguesa, inglesa e espanhola. Foram analisados 11 artigos e com resultados acerca das populações surda e ouvinte. Nos artigos com pessoas surdas observam-se temáticas sobre identidade, cultura e direitos enquanto cidadãos para dirimirem e modificarem os estereótipos acerca da surdez. As pesquisas com os ouvintes foram realizadas com os familiares e a sociedade de modo geral, tendo como destaque representações baseadas em estereótipos negativos e aspectos limitantes. Ademais, sugerem-se novas produções cientificas que deem continuidade à teoria das representações sociais associadas com outros aspectos que envolvam a surdez e tenham como amostra, a comunidade surda.
Preoperative Hormone Therapy in the Treatment of Breast Cancer: What Do We Know So Far?
Authors: Vorotnikov V. V. , Pakhomova R. A. , Soinov A. V. , Gunina A. S. , Kopytich I. V. , Tsoi M. G. , Abdugafforov S. A.
Published: October 2022

Breast cancer is the most common malignant disease in the world. One of the methods of treating breast cancer is neoadjuvant chemotherapy. Neoadjuvant chemotherapy (NCT) is now the standard of care for locally advanced breast cancer. Patients with HER2-positive and triple-negative breast cancer subtypes benefi t the most from NCT, with a 50–60 % chance of achieving pCR, while patients with hormone-sensitive, HER2-negative breast cancer subtypes have an average chance of achieving pCR of 10–20 %. For patients with locally advanced, hormone-sensitive Her2neu-negative breast cancer, neoadjuvant hormone therapy contributes to a tumor downstaging and an increasing rate of organ-preserving surgery. However, neoadjuvant hormone therapy is still not used routinely. There are a limited number of clinical guidelines that describe the choice of the optimal drugs, the optimal duration of hormone therapy and the criteria for selecting patients for preoperative hormone therapy. This is the first literature review in Russia that includes a systematization of the evidence regarding the effectiveness of neoadjuvant hormone therapy, a comparison of hormone therapy with neoadjuvant chemotherapy, comparison of hormonal drug groups, optimal duration of hormone therapy, attempts to combine hormone therapy with drugs of the group of selective CDK4/6 cyclin-dependent kinase inhibitors and phosphatidylinositol 3-kinase inhibitors for women with locally advanced hormone-sensitive Her2neu-negative breast cancer. The possibilities of using modern commercial multigene panels to assess the feasibility of identifying the cohort of patients for whom neoadjuvant hormone therapy would be most effective are also considered.
Radiomic Study for Objectification of Diagnostics and Complex Treatment of Glioblastoma
Authors: Nikulshina Ya. O. , Redkin A. N. , Kolpakov A. V. , Zakharov M. A.
Published: October 2022

Introduction.Glioblastoma is a neuroepithelial malignant brain tumour of predominantly astrocytic origin with an aggressive course and an extremely unfavorable prognosis. Since the median of overall survival with glioblastoma is 14.6 months after complex treatment that includes a combination of surgical treatment, radiation therapy and chemotherapy, the development a personalized approach in the diagnosis and treatment of glioblastomas is appeared to be urgent.

Materials and methods. MRIs of a patient undergoing chemoradiotherapy for glioblastoma G4 were performed on the following MRI scanners: Philips Ingenia 1.5T and Philips Ingenia Ambient 1.5T. The analysis of MR-images was carried out using the Matlab 2021 apps.

Results and discussion.MR-images were analyzed before and after surgery, and after a course of chemoradiotherapy. The statistical characteristics of the local brightness distribution of the lesion image, which are described by statistical texture parameters, were analyzed as informative features of the lesion area on the images. Initial confirmation of the ability to objectify diagnosis and treatment using the above statistical parameters of T2 MR images of lesion area has been obtained.

Conclusion.The aim of further research in this area is to use radiomic study for planning and monitoring the treatment of high-grade gliomas, estimate disease outcomes, and analyze the response to complex treatments in a predictive way.
A Rare Case of Cholangiocellular Liver Cancer with Hematogenous Metastases and Organ Changes in the Generalization of the Process
Authors: Vorobeva O. V.
Published: October 2022

Introduction. Cholangiocellular cancer is a malignant tumor from the epithelium of the bile ducts. Intravital diagnosis is often difficult to make due to the absence of any definitive signs of cancer and problems with detecting the first signs. Following the relevance of the problem, a case of cholangiocellular liver cancer with generalized metastases is presented.

Materials and methods. The analysis of the received supporting medical documentation and the description of macroand micropreparations using histological (hematoxylin and eosin staining) and immunohistochemical methods were carried out.

Results and discussion. Patient L.M., 60 years old, died at home, was referred by a general practitioner to the pathology department for autopsy examination. During the forensic autopsy, the macroscopic examination revealed dense liver substance, a «tree-like» mass of gray-yellow-brown color on the sections around the portal vein and intrahepatic bile ducts, with involvement of the right and left liver lobes and multiple gray nodules located throughout the liver parenchyma. The intrahepatic bile ducts malfunction due to expanding tumor tissue. Histological examination revealed a moderately differentiated tumor growth of cholangiocellular carcinoma, consisting of polymorphic cells separated by layers of fibrous tissue with areas of necrosis, foci of cholestasis. Immunohistochemical analysis of the tumor tissue of the lungs, liver: cytokeratins CAM 5.2 (+). All groups of lymph nodes of hepatoduodenal ligament, along vesicular and common bile ducts, hepatic artery and portal vein, surrounding left gastric and common hepatic artery, as well as lymph nodes of posterior pancreaticoduodenal group and distant lymph nodes are celiac; upper mesenteric and paraaortic zones appear unremarkable. Cerebral edema, pulmonary edema and necronephrosis were reported.

Conclusion. The presented case is of particular interest to practitioners owing to the absence of the characteristic lymph node metastases and presence of hematogenous metastases and development of multiple organ failure.
Layout nemocnice v kontextu zajištění spokojenosti pacientů a připravenosti na hromadné postižení osob: případová studie
Authors: Lochmannová Alena
Published: October 2022

Pomocné služby, jako jsou ty, které poskytuje logistika, se zdají být jednoduché a přímočaré, ale nemocnice jejich úlohu často přehlížejí. Činnosti související s logistikou významně ovlivňují kvalitu zdravotní péče i náklady nemocnic. Nemocniční logistika přispívá k poskytování péče pacientům tím, že zajišťuje, aby všechny potřebné služby a zdroje (tj. personál, zařízení a vybavení) byly dodány ve správný čas. V současném kontextu omezování nákladů, kdy nemocnice musí pečlivě hospodařit s veřejnými prostředky, je zlepšení řízení těchto omezených zdrojů stále naléhavější . Příspěvek představuje uplatnění základních logistických principů v rovině layoutů nemocnice v reflexi přípravy na události hromadného postižení osob a s ohledem na management příjmu pacientů v reflexi klasifikace onemocnění a disabilit v rovině příslušných klinik za účelem zajištění spokojenosti pacientů. Svým obsahem zároveň přibližuje dílčí aspekty nemocniční logistiky jakožto specifické součásti logistiky nemocničních zařízení.
Analysis of intercomponent relations in metageosystems by using simulation modeling
Authors: Yamashkin Stanislav Anatolyevich , Yamashkina Ekaterina Olegovna , Nikulin Vladimir Valerievich
Published: October 2022

The article focuses on solving the scientific problem of quantitative analysis of intercomponent relationships in metageosystems of different hierarchical levels by using the method of simulation modeling. Studying the structure and properties of metageosystems proved to be based on the analysis of the regularities of interaction of the territorial components distributed in space. A list of requirements for the framework of simulation models of spatial processes is formulated, an algorithm for developing a model that describes the spatial-temporal processes occurring in territorial systems is presented. There have been singled out two directions for developing the framework of simulation modeling of spatial processes: deductive, in which the model building system must be initially designed in order to achieve the coverage

of solutions to the maximum number of tasks, and inductive, in which positive changes in the particular models turn into the basis for the development of the simulation framework. The combined use of deductive and inductive strategies will evolutionize the upgraded modeling framework and optimize the particular solutions developed on its basis. As an example of implementation of a software package that demonstrates the possibilities of simulation modeling for solving the problem of analyzing intercomponent relations in metageosystems there has been developed an information system for modeling traffic flows in urban metageosystems. The developed system consists of the following modules: a map editor, a component for working with a database, a subsystem for visualizing interactive graphical web interfaces, an auxiliary module for performing the necessary mathematical calculations, a subsystem for modeling urban traffic, and a recommender subsystem for generating recommendations based on rules. The implemented software package for simulating traffic flows in urban metageosystems can be used to create dynamic transport models able to predict the flow depending on the situation. The model serves as a tool for making strategic decisions regarding the development of the spatial struc-ture of a city or region. The system modules aggregate interacting with each other and ensure the reliable and uninterrupted operation of the simulation system as a whole.
Calculating analytical functions in astronomical problems based on determining correct numbers in arithmetic operations
Authors: Popova Elena Vladimirovna
Published: October 2022

The article considers a model for determining the correct numbers when performing arithmetic operations and calculating analytical functions. At the output of the model there are received an exact number of correct digits as a result of operations with inaccurate numbers. Applied astronomical problems used to study the model can be solved by using tools that, due to errors in floating point calculations, receive inaccurate numbers. The lack of control over the correct digits can lead to setting an underestimated value of the argument in the output methods resulting in a loss of the correct digits or to an excessive value of the argument which creates the illusion of high accuracy. Inaccurate numbers that are used in different operations in the astronomical problems get the exact quantitative values of the correct numbers with the help of the proposed model and can get rid of dubious numbers that do not contribute to the accuracy of the result. Formulas for determining the number of correct digits are considered, with and without taking into account the first significant digits. The research may be directed to further extension of the model for complex calculations of non-analytical functions.
Pengaruh Total Pajak Penghasilan, Independensi Dewan Komisaris, Struktur Kepemilikan, dan Kualitas Audit Terhadap Manajemen Laba
Authors: Yispa Ienvika
Published: October 2022

Perusahaan telah lama diduga melakukan praktik manajemen laba yang mengaburkan realitas ekonomi suatu perusahaan. Penelitian ini bertujuan untuk menguji pengaruh pajak penghasilan, independensi Dewan Komisaris, kepemilikan manajerial, kepemilikan institusional, dan kualitas audit terhadap manajemen laba. Sementara pajak penghasilan diperkirakan berpengaruh positif terhadap manajemen laba, independensi Dewan Komisaris, kepemilikan manajerial, kepemilikan institusional, dan kualitas audit diperkirakan diprediksi berpengaruh negatif terhadap manajemen laba. Selain itu, ukuran, profitabilitas, dan leverage dimasukkan dalam model untuk mengontrol perbedaan karakteristik perusahaan. Sampel diambil dari Bursa Efek Indonesia periode 2016-2020. Analisis regresi linier diterapkan untuk uji hipotesis. Hasil penelitian menunjukkan bahwa pajak penghasilan berpengaruh positif terhadap manajemen laba. Kualitas audit berpengaruh negatif terhadap manajemen laba. Sebaliknya, dewan komisaris, kepemilikan manajerial, dan kepemilikan institusional tidak berpengaruh terhadap independensi manajemen laba. Untuk variabel kontrol, hasil penelitian menunjukkan bahwa ukuran perusahaan tidak berpengaruh terhadap manajemen laba. Profitabilitas dan leverage berpengaruh terhadap manajemen laba
Analisis Neraca Massa Pada Pembuatan Serbuk Pewarna Alami Daun Sawi (Brassica rapa var. parachinensis L.)
Authors: Ermawati Diana , Wiyono Andi Eko
Published: October 2022

Dyes made from natural ingredients sourced from animals and plants are used as food coloring. One of the natural green dyes is obtained from leaves that contain chlorophyll. One of the leaves that can be used as a dye is mustard greens because it contains chlorophyll. The purpose of this study was to analyze the mass balance in the process of making mustard leaf (Brassica rapa var. parachinensis L.). This research was conducted using laboratory experimental methods. The production of natural dye powder for mustard leaves is carriec out by means of material preparation,washing, blanching, extraction, addition of MgCO3 powder making and size reduction. The process ofmaking mustard leaf natural dye using mustard leaf 100 g, MgCO3 0,14 g, Tween 80 3,5014 g, and maltodextrin 35,014 g result in 33,8 g of dye powder. The mass balance of the process of making mustard leaf natural dye produces a final yield of 24,40%, the efficiency of the process in the powder making process is 0,087 (100%) with the highest mass loss in the blanching of 1.032 g.
Pengaruh Suhu dan Waktu Proses Pengeringan Terhadap Sifat Fisik dan Kimia Tepung Okra (Abelmoschus Esculentus L. Moench)
Authors: Nugroho Samuel Abdiel , Hariono Budi
Published: October 2022

Okra (Abelmoschus Esculentus L. Moench) is one type of vegetable that is included in functional vegetables, which means that okra contains various health benefits. The high water content causes okra vegetables to be easily damaged by microorganisms. the food industry varies depending on the commodity to be processed or dried. The parameters of this research are the treatment time and temperature of drying okra to become okra flour, namely 8 hours, 9 hours, and 10 hours with the temperatures given are 50˚C, 60˚C, 70˚C, with analysis of physical properties including yield, fineness, color and chemical properties including moisture content and antioxidants as well as organoleptic testing. The application of time and temperature in the drying process affects the physical and chemical properties, the longer the drying time and the higher the temperature used, the lower the yield of okra flour with a value of 2.90% at 70˚C temperature treatment with a time of 10 hours, the water content contained in okra flour is getting smaller at 70˚S temperature treatment with a time of 10 hours by 10% fault, the color produced by okra flour tends to be bright with a white degree value at 70˚C temperature treatment with a time of 9 hours at 48.48, antioxidant activity in okra flour increased with drying time with the highest value at a temperature of 50˚C with a temperature treatment for 10 hours of 71.71%. Testing the level of preference of the panelists using the hedonic method and the hedonic quality showed that the hedonic test or the panelists' grief gave the highest value to okra flour with a temperature treatment of 70˚C with a temperature of 9 hours with a color value of 3.40, aroma 3.75, texture 3.30, the appearance of 3.40, for the value of hedonic quality the panelists gave various values, the highest color value was 3.45 at a temperature treatment of 50˚C with a time of 8 hours, the highest value of aroma was 3.50 at the treatment of 50˚C with a temperature of 9 hours, and with the highest texture value of 3.50 with a temperature treatment of 70˚C with a time of 10 hours.
PENGARUH PERUBAHAN TARIF, MODERNISASI, METODE PENGHITUNGAN, INSENTIF PAJAK TERHADAP KEPATUHAN WAJIB PAJAK UMKM
Authors: Yuliani Yeni , Yanti Harti Budi
Published: October 2022

Riset ini bertujuan guna menganalisa dampak perubahan tarif pajak, modernisasi sistem perpajakan, metode penghitungan pajak, pemanfaatan insentif pajak terhadap kepatuhan wajib pajak UMKM. Dalam analisis ini, kami fokus pada usaha menengah ke kecil (UMKM) di Jakarta. Seratus peserta digunakan, dan tanggapan mereka diambil sampelnya secara acak dan kemudian dibandingkan dengan data yang diperoleh dengan kuesioner. Pentingnya pemilihan topik penelitian adalah untuk mengetahui kepatuhan wajib pajak UMKM di Kota Jakarta. Analisis regresi linier berganda dan analisis regresi moderator digunakan untuk menganalisis data. Temuan penelitian ini menunjukkan : 1) Perubahan tarif pajak tidak berpengaruh terhadap kepatuhan wajib pajak; 2) Peningkatan kepatuhan wajib pajak UMKM sebagian dapat dikaitkan dengan evolusi sistem perpajakan; 3) Tidak ada hubungan antara metode penghitungan pajak dengan kepatuhan wajib pajak UMKM; 4) Kepatuhan wajib pajak badan usaha milik minoritas dan perempuan (UMKM) dapat ditingkatkan melalui penerapan insentif perpajakan.
DESKRIPSI KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS DITINJAU DARI SELF-REGULATED LEARNING
Authors: Pasha Veda Fitaloka , Aini Indrie Noor
Published: October 2022

Penelitian ini bertujuan untuk menganalisis kemampuan pemahaman konsep matematis pada materi bentuk aljabar ditinjau dari self-regulated learning. Subjek dalam penelitian deskriptif kualitatif ini berjumlah 4 orang siswa SMP kelas VII di daerah Telagasari Karawang Jawa barat yang dipilih secara purposive sampling. Instrumen utama ialah peneliti sendiri, sedangkan instrumen pendukung yang dipakai dalam penelitian ini adalah soal uraian yang berjumlah tiga soal. Analisis data yang digunakan dalam penelitian ini adalah analisis jawaban siswa yang merujuk pada ketujuh indikator kemampuan pemahaman konsep matematis serta melaksanakan wawancara tak terstruktur. Hasil penelitian ini memperlihatkan bahwasanya siswa 1 dan 2  hanya mampu memenuhi tiga indikator yakni menyatakan ulang sebuah konsep, menyajikan konsep dalam berbagai untuk representasi matematis dan menggunakan, memanfaatkan, juga memilihkan prosedur ataupun operasi tertentu juga mengaplikasikan konsep ataupun algoritma pemecahan masalah sementara siswa 3 dan 4 hanya mampu memenuhi satu indikator yakni menyebutkan ulang sebuah konsep. Sehingga dapat disimpulkan bahwa kemampuan pemahaman konsep matematis bentuk aljabar ditinjau dari self-regulated learning tergolong rendah. Hal itu dapat diperkuat dengan hasil wawancara pada siswa yang memperlihatkan bahwasanya ketiga siswa mempunyai kemampuan self-regulated learning yang rendah.
PERBANDINGAN PREDIKSI MASSA PARTIKEL SUB ATOM MENGGUNAKAN TEORI UKUR KUANTUM DAN TEORI UKUR
Authors: Fikri Miftahul
Published: October 2022

Sejak tahun 1900 ketika Max Planck menggunakan istilah kuantum untuk mengamati radiasi benda hitam, eksperimen tentang kuantum terus berkembang. Dalam perkembangannya, teori ukur kuantum merupakan hal mendasar yang sangat dibutuhkan karena menjadi fondasi dalam perhitungan maupun analisis terkait partikel-partikel sub atom. Sebagaimana diketahui bahwa teori ukur merupakan teori operasi dasar di matematika yang digunakan dalam kehidupan sehari-hari seperti operasi aljabar, operasi pada analisis riil, dan penerapan operasi pada berbagai bidang. Teori ukur kuantum merupakan generalisasi teori ukur yang memenuhi sifat countable additive menjadi weak countable additive. Akibatnya dalam perhitungan yang mendasar sekalipun menjadi tidak relevan pada partikel sub atom jika digunakan teori ukur. Dalam penelitian ini, dilakukan prediksi/ perhitungan massa partikel sub atom berupa meson dan barion baik menggunakan teori ukur kuantum maupun menggunakan teori ukur. Hasil prediksi menunjukkan bahwa dengan teori ukur kuantum diperoleh rata-rata akurasi prediksi massa partikel sub atom sebesar 92.3%, sedangkan dengan teori ukur sebesar 48.17%. Hasil akurasi sebesar 48.17% untuk teori ukur menunjukkan bahwa teori ini tidak relevan jika diterapkan pada obyek kuantum. Adapun akurasi sebesar 92.3% untuk teori ukur kuantum menunjukkan teori ini dapat digunakan untuk menganalisis obyek kuantum lebih lanjut seperti menganalisis energi nuklir, fenomena partial discharge, quantum computing, serta fenomena sub atom lainnya.
Using Technology to Address Cross Border Crime and Illegal Migration: The Case of South Africa
Authors: Mlambo Victor H. , Adetiba Toyin C. , Thusi Xolani
Published: October 2022

The 1996 Constitution of South Africa includes the right of every South African to freedom and security. It is the government’s responsibility to guarantee that national security is maintained and that residents within the limits of South African borders are protected. Based on this assumption, the issue of border management and migration regulations is presumed to be critical. Poor border management and unregulated migration jeopardise national security and endanger residents’ freedom and security. This article contends that South Africa’s inadequate border control and unrestrained migration have jeopardised the country’s national security. As a result of the inadequacy of border control in South Africa, South Africans have resorted to various xenophobic actions, with many foreign nationals losing their lives in the process. This article examines the current policy responses to migration and security at border crossings and what has gone wrong in South African border management. A qualitative research technique was used to fulfil the goals of this paper.
CORRUPÇÃO ESTATAL E OS SEUS IMPACTOS SOBRE A DEMOCRACIA E A ECONOMIA
Authors: Silva de Oliveira André
Published: October 2022

O objetivo do presente artigo consiste em abordar criticamente como a literatura institucionalista, sobretudo em ciência política, trata os impactos deletérios produzidos pela corrupção estatal sobre o funcionamento da democracia e o desempenho da economia. Até os anos 1960, como então chegou a sustentar Samuel Huntington, acreditava-se que algum nível de corrupção estatal era admissível como necessário à promoção do desenvolvimento econômico de cada país. Ao longo do tempo, todavia, as pesquisas modificaram esse entendimento e passaram a indicar que a corrupção estatal concorre simultaneamente para a erosão das instituições democráticas, bem como bloqueia o desenvolvimento econômico sustentável. A discussão se torna relevante quando se observa que no Brasil a Operação Lava Jato se encontra em franco recuo, principalmente em razão de recentes decisões do Supremo Tribunal Federal. Cotejando o panorama político-institucional brasileiro com a literatura revisitada, a conclusão principal aponta para a falta de consenso coletivo sobre o tema ora escrutinado, o que pode afetar a mudança da trajetória dependente de um passado burocrático-patrimonialista.
Cardiac troponins as biomarkers of cardiomyocyte damage in arterial hypertension: emphasis on pathophysiological mechanisms
Authors: Чаулин А.М.
Published: October 2022

Введение. Многие патологические состояния различного генеза вызывают повреждение кардиомиоцитов (КМЦ). Одним из наиболее чувствительных и специфичных критериев оценки степени повреждения КМЦ являются сердечные тропонины (СТ) - регуляторные белковые молекулы, которые высвобождаются в сыворотку крови из КМЦ при их гибели или повреждении. Новые высокочувствительные методы детекции СТ позволяют выявлять незначительные повреждения КМЦ на самых ранних стадиях сердечно-сосудистых патологий, в связи с чем могут изменить представление о патогенезе и открыть новые диагностические возможности. Цель обзора - обобщение патофизиологических механизмов, лежащих в основе повреждения КМЦ и высвобождения СТ в сосудистое русло при артериальной гипертензии и обсуждение клинического значения изменения уровня СТ у пациентов, страдающих артериальной гипертензией. Методика. При подготовке обзора были использованы отечественные (elibrary/РИНЦ) и зарубежные (Embase, Pubmed/Medline) базы данных. Заключение. В повреждении КМЦ и высвобождении СТ при артериальной гипертензии задействованы следующие патофизиологические механизмы: гипертрофия миокарда, апоптоз КМЦ, повреждение клеточной мембраны КМЦ и повышение ее проницаемости для молекул СТ, а также изменение скорости клубочковой фильтрации в почках. С учетом данных о прогностической ценности уровня СТ при артериальной гипертензии открываются перспективы для использования этих биомаркеров при выборе тактики ведения пациентов.

Introduction. Many pathological conditions, both of cardiovascular and extra-cardiac genesis, cause damage to cardiomyocytes (CMC). One of the most sensitive and specific criteria for the detection of CMC damage are cardiac troponins (CT), regulatory protein molecules that are released into the blood from CMC when these cells are killed or damaged. New, highly sensitive methods for detecting CT can identify minor damage to CMC at the earliest stages of cardiovascular pathologies. Thus, these methods may change the understanding of the pathogenesis and suggest new diagnostic possibilities. The aim of this review was to summarize the pathophysiological mechanisms underlying the damage to CMC with the release of CT and to discuss the clinical significance of elevated CT in arterial hypertension. Methods. In the search for literature, Russian (elibrary/RSCI) and international (Embase, Pubmed/Medline) databases were used. The following keywords were used: myocardial damage, cardiac troponins, arterial hypertension, pathophysiology. Conclusion. The CMC damage and the CT release in arterial hypertension are mediated by the following pathophysiological mechanisms: myocardial hypertrophy, CMC apoptosis, damage to the CMC cell membrane and its increased permeability to CT molecules, and changes in the glomerular filtration rate. Taking into account the prognostic value of CT in arterial hypertension, there are prospects for using these biomarkers in choosing tactics for management of patients.
The Arctic area of knowledge in social and humanitarian sciences
Authors: ХАРЛАМПЬЕВА Н.К.
Published: October 2022

В статье представлено научное и научно-методическое обоснование применения мирополитического подхода и водно-бассейнового принципа в формировании современного пространства знания о Севере и Арктике в сфере общественных и гуманитарных наук. В качестве примера представлены разработки научной школы ААНИИ по изучению устьевых регионов Российской Арктики и кафедры мировой политики СПбГУ по актуализации природоохранной и народосберегающей тематики в условиях холодного климата.Предлагается методология организации образовательной, научно-исследовательской и научно-методической деятельности с выявлением арктических особенностей в таких направлениях как: а) процесс принятия решений по природоохранным вопросам и участия в них гражданского общества, б) изучение истории межкультурной и социолингвистической коммуникации, в) определение роли и места историко-культурного наследия Арктики. Важность рассматриваемых направлений обоснована уточнением трех направлений управленческой деятельности: государственного администрирования, корпоративного менеджмента и общественных слушаний.Пространством знания Арктики предлагается признать территорию водосбора бассейна Северного Ледовитого океана на основе схемы арктической устьевой гидрологии.Современные вопросы сочетания государственного мониторинга и природоохранного законодательства Российской Федерации в водно-экологических границах одна из тем обсуждения совместных научных мероприятий СПбГУ и ААНИИ с учетом интересов населения, проживающего в условиях холодного климата.На примере маленького ручейка Юмюлюн, берущего начало на территории муниципального образования Оргетского наслега (як. Өргүөт) Верхневилюйского района Республики Саха (Якутия) Российской Федерации дается возможность создания модели краеведческой деятельности по изучению государственного мониторинга и управления территориями водных объектов в их естественной экологической среде водосборов р. Вилюй, Ленской устьевой области, бассейна моря Лаптевых и Северного Ледовитого океана с учетом региональных, федеральных и международных процессов формирования водных отношений и принятия природоохранных решений.
New Nucleic Base-tethered Trithiolato-bridged Dinuclear Ruthenium(II)-Arene Compounds: Synthesis and Antiparasitic Activity
Authors: Desiatkina Oksana , Mösching Martin , Anghel Nicoleta , Boubaker Ghalia , Furrer julien , Amdouni Yosra , Hemphill Andrew , Păunescu Emila
Published: October 2022

Aiming to generate novel compounds with improved antitoxoplama activity by exploiting the parasite auxotrophies, a library of nucleic base-tethered trithiolato-bridged dinuclear ruthenium(II)-arene conjugates - was synthesized and evaluated. Various structural features as the nucleobase (adenine, uracil, cytosine, thymine, and xanthine) and the linker between the two units were progressively modified. To substantiate the concept, hybrid molecules comprising the diruthenium moiety and other type of pendant molecules were also synthesized and assessed. The use of the CuAAC (copper catalyzed azide-alkyne cycloaddition) approach for the obtainment of conjugates bearing the trithiolato diruthenium scaffold was validated. 37 Compounds (diruthenium conjugates and corresponding intermediates) were assessed in a primary screening for in vitro activity against transgenic Toxoplasma gondii tachyzoites constitutively expressing β-galactosidase (T. gondii β-gal) at 0.1 and 1 μM. In parallel the cytotoxicity in non-infected host cells (human foreskin fibroblasts, HFF) was determined by alamarBlue assay. 20 Compounds strongly impairing parasite proliferation with little effect on HFF viability were subjected to T. gondii β-gal dose-response studies (IC50, half maximal inhibitory concentration determination) and their toxicity for HFF was assessed at 2.5 μM. Two compounds showing promise for further development were identified: 14, ester conjugate with 9-(2-oxyethyl)adenine, and 36, a click conjugate bearing a 2-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl substituent, with IC50 values of 0.059 and 0.111 μM respectively, significantly lower compared to the standard drug pyrimethamine (IC50 = 0.326 μM). Both 14 and 36 exhibited low toxicity against HFF when applied at 2.5 μM and are candidates as potential treatment options in a suitable in vivo model.
Quantitative and Repetitive Control of Subcellular Protein–Protein Interaction Using a Photochromic Dimerizer
Authors: Mashita Takato , Kowada Toshiyuki , Yamamoto Hayashi , Hamaguchi Satoshi , Matsui Toshitaka , Mizukami Shin
Published: October 2022

Artificial control of intracellular protein dynamics with high precision provides deep insight into complicated biomolecular networks. Optogenetics and caged compound-based chemically induced dimerization (CID) systems are emerging as tools for spatiotemporally regulating intracellular protein dynamics. However, both technologies face several challenges for accurate control such as the duration of activation, deactivation rate, and repetition cycles. Herein, we report a photochromic CID system that employs the photoisomerization of a ligand so that both association and dissociation are controlled by light, enabling quick, repetitive, and quantitative regulation of the target protein localization upon violet and green light illumination. We also demonstrated the usability of the photochromic CID system as a potential tool to finely manipulate intracellular protein dynamics to study diverse cellular processes. Utilizing this system to manipulate PINK1/Parkin-mediated mitophagy, we showed that PINK1 recruitment to the mitochondria can promote Parkin recruitment to proceed with mitophagy.
Why the reaction order of biomolecular reaction should be 2.33 instead of 2?
Authors: Chen Jixin
Published: October 2022

Predicting the reaction kinetics, that is, how fast a reaction can happen in a solution, is essential information for many processes, such as industrial chemical manufacturing, refining, synthesis and separation of petroleum products, environmental processes in air and water, biological reactions in cells, biosensing, and drug delivery. Collision theory was originally developed to explain the reaction kinetics of gas reactions with no dilution. For a reaction in a diluted inert gas solution or a diluted liquid solution, diffusion often dominates the collision process. Thus, it is necessary to include diffusion in such a calculation. Traditionally the classical Smoluchowski rate is used as a starting point to predict the collision frequency of two molecules in a diluted solution. In this report, a different collision model is derived from the adsorption of molecules on a flat surface. A surprising result is obtained showing that the reaction order for biomolecular reaction should be 2 and 1/3 instead of 2, following a fractal reaction kinetics.