bluuebunny/crossref_metadata_2025 huggingface dataset:
ISTIKHDĀM TIKNŪLŪJĪ AL-TA'LĪM ATSNĀ INTIṮAR AL-WABĀ LI MAHĀRĀT AL-LUGAH AL-'ARABIYYAH
Authors: Riyadi H M
Published: November 2021

That learning technology has many benefits in its use during a pandemic in Arabic learning to improve Arabic language learning, both in its planning, implementation and evaluation. Therefore, for Arabic language teachers during a pandemic in utilizing learning technology, they must be varied in making the material, presenting it, and giving assignments to increase the Arabic language maharah. The purpose of this study is to find out the use of learning technology during a pandemic at MAN Banjarmasin in increasing the Arabic language teaching and the supporting and inhibiting factors in its use. The methodology in this study uses a descriptive qualitative approach with data collection used: Observation, Interview and Documentation. The results in this study indicate that: 1) The use of learning technology during the pandemic at MAN Banjarmasin in increasing the Arabic language maharah varied in its planning, implementation, and evaluation and was able to increase student values in learning Arabic. 2) factors that support and hinder the lack of provision of facilities and infrastructure, lack of IT mastery, enthusiasm and enthusiasm of teachers and students with online learning, professional language teachers, high student interest, provision of varied materials.
TAHLĪL SĪGAH TADĀKHUL AL-LUGĀT AL-'UM FĪ AL-MUHĀDAṮAH AL-YAUMIYYAH BI AL-LUGAH AL-'ARABIYYAH
Authors: Maimunah Maimunah , Mukhtar Haniah
Published: November 2021

This research is focused on The interference mother language in arabic language use in the daily conversations of language. Nowadays, the very rapid advances in communication technology and science encourage humans to not only master one language, namely the Mother tongue, but also several foreign languages used in international forums, such as English and Arabic. Darul Hijrah Islamic Boarding School for girl in Martapura is one of the Islamic Boarding that requires students to use 2 languages in daily conversation, namely Arabic and English and apply a language environment to their acquisition. However, some students speak Arabic using elements of Indonesian language, grammar and mix with the Mother tongue during Arabic conversations. This is a qualitative research with a descriptive method. The subject of the research was the students' Arabic utterance. To analyze the data, the researcher used the following steps: data reduction, data presentation and conclusions, while the language speech data were analyzed using the error analysis method and comparative analysis
Genetic Algorithm for Variable Selection and Parameter Optimization in SVM and Fuzzy SVM for Colon Cancer Microarray Classification
Authors: Irhamah Irhamah , Faiqah Elok , Kuswanto Heri , Paramita NLP Satyaning Pradnya
Published: November 2021

Colon cancer is the second leading cause of cancer-related deaths in the world, hence research on that topic needs to be undertaken with improvement. Recent advanced in microarray technology allows the monitoring of the expression level of a large set of genes simultaneously. Microarray data is a type of high-dimensional data with hundreds or even thousands number of genes (features), while usually the number of patients observed (observations) is much smaller than the number of features. This study uses a colon cancer microarray dataset contains two class of genes, normal and tumor. The aims of this study is to develop a classification model using fuzzy support vector machines (FSVM) hybridized with genetic algorithm (GA) for classifying individuals based on gene expression. Fuzzy memberships was used in SVM in order to deal with the case of imbalanced microarray data. Meanwhile, the role of genetic algorithm is, firstly, to select the relevant genes as the features and, secondly, to optimize the parameter of FSVM as GA is able to handle the problem of nonlinear optimization that has a high dimension, adaptable, and easily combined with other methods. The classification using FCBF selection has a higher accuracy value than the ones without the selection. The results also show that FSVM that has been optimized using GA has the highest accuracy value compared to other classification methods used in this study.
The Confidence Interval of the Estimator of the Periodic Intensity Function in the Presence of Power Function Trend on the Nonhomogeneous Poisson Process
Authors: Maulidi Ikhsan , Wibowo Bonno Andri , Valentika Nina , Syazali Muhammad , Apriliani Vina
Published: November 2021

The nonhomogeneous Poisson process is one of the most widely applied stochastic processes. In this article, we provide a confidence interval of the intensity estimator in the presence of a periodic multiplied by trend power function. This estimator's confidence interval is an application of the formulation of the estimator asymptotic distribution that has been given in previous studies. In addition, constructive proof of the convergent in probability has been provided for all power functions.
On the Modification of Newton-Secant Method in Solving Nonlinear Equations for Multiple Zeros of Trigonometric Function
Authors: Juhari Juhari
Published: November 2021

This study discusses the analysis of the modification of Newton-Secant method and solving nonlinear equations having a multiplicity of  by using a modified Newton-Secant method. A nonlinear equation that has a multiplicity   is an equation that has more than one root. The first step is to analyze the modification of the Newton-Secant method, namely to construct a mathematical model of the Newton-Secant method using the concept of the Newton method and the concept of the Secant method. The second step is to construct a modified mathematical model of the Newton-Secant method by adding the parameter . After obtaining the modified formula for the Newton-Secant method, then applying the method to solve a nonlinear equations that have a multiplicity . In this case, it is applied to the nonlinear equation which has a multiplicity of . The solution is done by selecting two different initial values, namely  and . Furthermore, to determine the effectivity of this method, the researcher compared the result with the Newton-Raphson method, the Secant method, and the Newton-Secant method that has not been modified. The obtained results from the analysis of modification of Newton-Secant method is an iteration formula of the modified Newton-Secant method. And for the result of  using a modified Newton-Secant method with two different initial values, the root of  is obtained approximately, namely  with less than iterations. whereas when using the Newton-Raphson method, the Secant method, and the Newton-Secant method, the root  is also approximated, namely  with more than  iterations. Based on the problem to find the root of the nonlinear equation  it can be concluded that the modified Newton-Secant method is more effective than the Newton-Raphson method, the Secant method, and the Newton-Secant method that has not been modified
Local Hölder Regularity of Weak Solutions for Singular Parabolic Systems of p-Laplacian Type
Authors: Khoirunisa Khoirunisa , Karim Corina , Muslikh M.
Published: November 2021

In this paper, the Hölder regularity of weak solutions for singular parabolic systems of p-Laplacian type is investigated. By the Poincare inequality, we show that its weak solutions within Hölder space.
Harmonization of Laws on Electronic Contracts Based on International Instruments for the ASEAN Economic Community
Authors: Betlehn Andrew
Published: November 2021

Technological advancement has created new business practices such as utilizing electronic contracts. Utilization of electronic contracts, especially in international transactions, has pushed countries around the world to impose new regulations defining the legalities of electronic instruments. Challenges arise considering the global and borderless nature of electronic transactions faced with regulations of different countries that are not in sync with each other. This is especially apparent in Member States of the ASEAN Economic Community. This paper attempts to discover the ideal legal framework for electronic contracts in the ASEAN Economic Community. Based on the research and analysis, it has been found that there is a need for a harmonized legal framework regarding electronic commerce that can be adopted unaltered by Member States of the ASEAN Economic Community, which could be drafted by the ASEAN as an inter-governmental organization.
ANÁLISE DE POLÍTICAS PÚBLICAS: AVALIAÇÃO DA ESTRATÉGIA SAÚDE DA FAMÍLIA
Authors: Mendes Wanderson De Almeida , Faria Antônio Cláudio Lopes de , Gomes Adriano Provezano , Mendes Wesley De Almeida
Published: November 2021

Objetivo consiste em avaliar a ESF nos municípios mineiros através da análise de eficiência técnica. Como método, utilizou uma variação da Análise Envoltória de Dados, denominado de Modelo de Medidas Especiais, considerando o Índice Mineiro de Responsabilidade Social (IMRS) como variável de saída não-discricionária. Ainda, foi utilizado o método de Fronteira Invertida com o intuito de comparar a eficiência composta normalizada com o IMRS. Os resultados indicaram que os municípios situados em regiões mais pobres, tendem a ter menores desempenhos na ESF. Concluiu-se que o desempenho da ESF afeta outros setores, além de sofrer influência das condições econômicas locais e regionais.
Analysis of migration processes and their social component in the constituent entities of the Russian Federation: a collection of articles
Authors:   Volga Branch of FCTAS RAS, Nizhny Novgorod, Russian Federation, Ustinkin Sergei V. , Trufanov Alexander Yu. ,   Volga Branch of FCTAS RAS, Nizhny Novgorod, Russian Federation
Published: November 2021

В сборнике статей рассматриваются проблемы миграционной политики как в субъектах Российской Федерации, так и в западных странах. Исследование основано на привлечении широкого спектра источников социологического и статистического характера. Социологический мониторинг позволяет использовать методы, с помощью которых фиксируются не только происходящие события, но и то, как они воспринимаются людьми. В свою очередь, это дает возможность разносторонней оценке событий и служит важным фактором прогнозирования поведения людей в тех или иных ситуациях. Сборник адресован как научным сотрудникам и специалистам в социологии и регионоведении, так и управленцам местного, регионального и федерального уровней.
Goed gehoord, goed gezegd? Auditieve waarneming van het verschil tussen de Nederlandse [e:] en [ɛi] en de invloed ervan op articulatorische reproductie van de Nederlandse [e:] door Poolse moedertaalsprekers
Authors: Czerwonka-Wajda Zuzanna
Published: November 2021

The paper presents the results of a study on the audition of a Dutch tense vowel [e:] and the diphthong [ɛi] by Polish native speakers. It was hypothesized that Polish native speakers may pronounce the Dutch [e:] as a combination of [ɛ] and [j] because they generally fail to distinguish the [e:] from the diphthong [ɛi], as both sounds lie acoustically close to each other (especially those produced by speakers of Dutch from the Netherlands); moreover, they are absent from the Polish phonetic system. Instead, the experiment has shown that Polish native speakers are very good at differentiating the isolated Dutch [e:] and [ɛi]. It seems that the pronunciation of the Dutch [e:] as a combination of [ɛ] and [j] is rather a matter of articulation than audition, but further experiments are needed to examine the problem.
A mobiltárca elfogadásának generációs különbségei: az X és Z generáció összehasonlítása
Authors: Agárdi Irma , Alt Mónika Anetta
Published: November 2021

A fogyasztók a termékek és szolgáltatások vásárlása során egyre nagyobb arányban használnak készpénzmentes fizetési módokat, például a mobiltárcát. Az új technológia elfogadása nagyban függ a fogyasztók egyéni jellemzőitől. A szerzők a technológiaelfogadás és a generációs kohorszok elméletére alapozva arra keresik a választ, hogy a mobiltárca elfogadásában milyen különbségek mutatkoznak az X és Z generáció között. Az online megkérdezés 580 fős mintát eredményezett számukra, amelyet többcsoportos strukturális egyenletek módszerével (structural equation modeling, SEM) elemeztek. Kutatási eredményeik elméleti és a gyakorlati vonatkozásait részletesen kifejtik a tanulmányban. Az X és Z generáció mobiltárca-elfogadását eltérő tényezők határozzák meg. Az X generációt leginkább a könnyű használat, a fontos személyek véleménye, az élményszerűség és az alacsony pénzügyi kockázat befolyásolja döntése során. A Z generáció technológiaelfogadásában leginkább az életstílussal való kompatibilitás játszik kiemelt szerepet.
Workshop Penulisan Skripsi bagi Mahasiswa Calon Sarjana
Authors: Fitriah Lutfiyanti
Published: November 2021

Kegiatan pengabdian masyarakat ini bertujuan untuk melatih dan mengembangkan kemampuan mahasiswa calon sarjana dalam menulis skripsi melalui kegiatan workshop. Metode yang digunakan dalam pengabdian ini adalah ceramah, tanya jawab, dan penugasan. Peserta pengabdian adalah 82 orang mahasiswa. Kegiatan workshop berjalan dengan berhasil dan lancar. Berdasarkan kegiatan yang dilaksanakan menunjukkan peserta sangat puas dengan kegiatan ini yang ditandai dengan skor rata-rata kepuasan sebesar 4,56 dengan kategori sangat baik.  Hasil dari kegiatan ini dapat memotivasi mahasiswa untuk menyelesaikan skripsi serta melatih dan mengembangkan kemampuan mahasiswa menulis skripsi.  Community service aimed to train and develop the competence of undergraduate students to write a thesis through a workshop. The methods used in this service were lectures, questions, and assignments. The service participant were 82 students. The workshop went successful and smoothly. Based on those activities, participants were satisfied with this workshop with an average satisfaction of 4.46 with a very good category. This service can help motivate students to finish their thesis and train and develop their competence to write a thesis.
Ayurveda and the medical knowledge in ancient India: Shadows and realities
Authors: Sebastian CD
Published: November 2021

Ayurveda is the Indian system of professional medicine that has come down to us from ancient times. In this paper, I look at the system from a researcher’s point of view, critically examining the given or perceived view on Ayurveda in recent times. In this sense, it might look like a contrarian view or counter position to the narrative that one sees around with regard to its origin, place of origin, date, non/religious background, etc. The paper deals with Ayurveda as an independent tradition of medicine sans ascription to any religion, the possible influences of other systems on Ayurveda, and the three great luminaries of the system, namely, Caraka, Susruta, and Vagbhata.
Physical Bases of Boron Neutron Capture Therapy, Dosimetry, and Its Mechanisms of Action—A Critical Overview of the Literature
Authors: Skwierawska Dominika , Balcerzyk Marcin , Lopez-Valverde Jose Antonio , Leal Antonio
Published: November 2021

The success of boron neutron capture therapy (BNCT) depends mainly on sufficient spatial biodistribution of boron (B-10) localized around or within neoplastic cells to produce a high dose gradient between the tumor and healthy tissue. Contrary to what is usual in radiotherapy, BNCT proposes treatment planning directed at the cell rather than the tumor mass. However, it is not yet possible to precisely determine the concentration of B-10 in a specific tissue in real-time using non-invasive methods. Some critical issues still need to be resolved if BNCT is to become a valuable, minimally invasive, and efficient cancer treatment. This review article provides an overview of the funda-mental principles, recent advances, and future directions of BNCT as a cell-targeted cancer therapy. The main emphasis is on topics related to biological dosimetry, methods for assessing boron concentration, mechanisms of action of BNCT, and its physical bases for clinical implementation.
The Concept of “New Media” Among News Producers
Authors: Alzyoud Shlash
Published: November 2021

The aim of this study is to understand how Jordanian journalists view social media networks as being related to the news industry and the extent of their dependence on these networks in producing news. It also explores the opinions of journalists on the pros and cons of these networks through the lens of relationship between these networks and professional journalism. The study uses the qualitative approach by conducting interviews with a number of professional Jordanian journalists. The most prominent results that the study revealed are that journalists view social networks as an important and beneficial development. There is optimism among journalists about the relationship between professional journalism and social media. Also, social networks have brought several benefits to the professional journalism. The results also show that there is a firm belief among journalists that social networks cannot be considered a substitute for traditional media.
Stress and Adjustment During the COVID-19 Pandemic: A Qualitative Study on the Lived Experience of Older Adults
Authors: Fiocco Alexandra J. , Gryspeerdt Charlie , Franco Giselle
Published: November 2021

In response to the COVID-19 pandemic, social distancing measures were put into place to flatten the pandemic curve. It was projected older adults were at increased risk for poor psychological and health outcomes resulting from increased social isolation and loneliness. However, little re-search has supported this projection among community-dwelling older adults. While growing body of research has examined the impact of the COVID-19 pandemic on older adults, there is a paucity of qualitative research that captures the lived experience of community-dwelling older adults. The current study aimed to better understand the lived experience of community-dwelling older adults during the first six months of the pandemic. Semi-structured one on one interviews were conducting with independent living older adults aged 65 years and older. After achieving saturation, 22 interview were analyzed using inductive thematic analysis. Following a recursive process, two overarching themes emerged from the data: perceived threat and challenges of the pandemic and coping with the pandemic. Specifically, participants reflected on the threat of contracting the virus and challenges associated with living arrangement, social isolation, and financial insecurity. Participants shared their coping strategies to maintain health and wellbeing, including behavioral strategies, emotion-focused strategies, and social support. Overall, this re-search highlights resilience among older adults during the first six months of the pandemic.
Hybrid Machine Learning for Solar Radiation Prediction in Reduced Feature Spaces
Authors: Hedar Abdel-Rahman , Almaraashi Majid , Abdel-Hakim Alaa E. , Abdulrahim Mahmoud
Published: November 2021

Solar radiation prediction is an important process in ensuring optimal exploitation of solar energy power. Numerous models have been applied to this problem, such as numerical weather prediction models and artificial intelligence models. However, well-designed hybridization approaches that combine numerical models with artificial intelligence models to yield a more powerful model can provide a significant improvement in prediction accuracy. In this paper, we propose novel hybrid machine learning approaches that exploit auxiliary numerical data. The proposed hybrid methods invoke different machine learning paradigms, including feature selection, classification, and regression. Additionally, numerical weather prediction (NWP) models are used in the proposed hybrid models. Feature selection is used for feature space dimension reduction to reduce the large number of recorded parameters that affect estimation and prediction processes. The rough set theory is applied for attribute reduction and the dependency degree is used as a fitness function. We investigate the effect of the attribute reduction process with thirty different classification and prediction models in addition to the proposed hybrid model. Then, different machine learning models are constructed based on classification and regression techniques to predict solar radiation. Moreover, other hybrid prediction models are formulated to use the output of the numerical model of Weather Research and Forecasting (WRF) as learning elements in order to improve the prediction accuracy. The proposed methodologies are evaluated using a data set that is collected from different regions in Saudi Arabia.
The Biogenic Synthesis of Reduced Graphene Oxide using Hibiscus sabdariffa L. as Natural Precursor
Authors: Albert Emmellie Laura , Tan Eddie Khay Ming , Teh Huey Fang , Mei Theresa Ng Lee , Abdullah Che Azurahanim Che
Published: November 2021

Owing to their extraordinary properties, carbon-based nanomaterials are gaining traction in biomedicine. Green synthesis is the cost-effective method for fabricating carbon-based nanomaterials due to its rapidity, renewable nature, and sustainability. This study emphasis on the graphene oxide (GO) reduction using a simple one-pot technique that does not require the use of toxic reducing agents. This article reports the green synthesis of reduced graphene oxide (RGO) using Hibiscus sabdariffa L. calyxes extract as the natural reducing agent. Additionally, this article also provides analysis RGO using X-ray diffraction (XRD), UV-Visible spectroscopy (UV-Vis), and Raman spectroscopy. XRD result showed that the GO peak at 11o diminished, and a new hump appear at 22o indicating that the GO is fully reduced when it is refluxed for 6 hours, at 100oC with 1:3 ratio of GO:PE. The UV-Vis data indicated absorption peak of GO (237 nm) and RGO (265 nm) at distinct locations. This finding shed new light on the enormous potential of Hibiscus sabdariffa L. calyxes extract for green GO reduction. As a result, this environmentally friendly method can help reduce dependence on chemical materials.
On the logic-game approach to the problems of working with big data
Authors: Khelemendik Roman Viktorovich
Published: November 2021

When working with big data, the problems of search, presentation, systematization, updating, analysis of information, application of artificial intelligence, communication, verification and understanding of conclusions are considered. Examples of solutions to some aspects of these problems, shown in the organization of work with information in chess, are given. The so-called logic-game approach is proposed, which provides ways to adapt and formalize solutions for a fairly wide range of problems with big data.
Search model for similar documents in the semantic library
Authors: Ataeva Olga Muratovna , Serebryakov Vladimir Alekseevich , Tuchkova Natalia Pavlovna
Published: November 2021

The problem of finding the most relevant documents as a result of an extended and refined query is considered. For this, a search model and a text preprocessing mechanism are proposed, as well as the joint use of a search engine and a neural network model built on the basis of an index using word2vec algorithms to generate an extended query with synonyms and refine search results based on a selection of similar documents in a digital semantic library. The paper investigates the construction of a vector representation of documents based on paragraphs in relation to the data array of the digital semantic library LibMeta. Each piece of text is labeled. Both the whole document and its separate parts can be marked. The problem of enriching user queries with synonyms was solved, then when building a search model together with word2vec algorithms, an approach of "indexing first, then training" was used to cover more information and give more accurate search results.
The initiation of the Mesoproterozoic Bylot basins (Nunavut, Arctic Canada) as recorded in the Nyeboe Formation, Fury and Hecla Group
Authors: Patzke Mollie , Greenman J. Wilder , Halverson Galen P. , Ielpi Alessandro
Published: November 2021

Reconstructing Precambrian sedimentary environments over broad cratonic regions often relies on a combination of facies, structural, and provenance analyses. The Mesoproterozoic (ca. 1270–1090 Ma) Fury and Hecla Group, exposed on the Melville Peninsula and northern Baffin Island (Nunavut, Canada), is considered broadly correlative with strata of the Borden, Hunting–Aston, and Thule basins (together referred to as the Bylot basins). We present the results of updated mapping and the first high-resolution sedimentologic and stratigraphic analysis of the lowermost unit in the Fury and Hecla Group, the Nyeboe Formation. The Nyeboe Formation comprises five distinct facies associations: alluvial to fluvial, eolian-backshore, marine-intertidal, marine foreshore to shoreface, and marine-offshore. Thin mafic units are interbedded within the marine shoreface facies and are interpreted to represent volcanic flows. Lateral relationships between facies associations are complex, but generally, facies associations transition from a terrestrial environment at the base to a nearshore marine environment at the top, indicating a transgression. Considering both the along-strike and -dip thickness trends, the presence of mafic volcanic rock units, and possible syndepositional fault orientations crosscutting the deposits, we infer that the Fury and Hecla Group was deposited in a regime of crustal thinning in a half-graben setting. Our results from the Nyeboe Formation suggest a lithostratigraphic correlation to the Nauyat and Adams Sound formations of the Borden Basin. Therefore, this study establishes a geodynamic link between the opening of the Fury and Hecla Basin to the other Bylot basins and contributes to the understanding of a large late Mesoproterozoic intracontinental-basin system.
Mechanism of Rockburst Prevention in Deep Thick Coal Seams with Cemented Paste Backfill: A Case Study
Authors: Chang Qingliang , Leng Qiang , Sun Xikui , Li Guichen , Zhang Biao
Published: November 2021

The aim of this study is to explore a safe mining method to effectively excavate the deep thick coal seams in rockburst-prone mines. Based on the theory of elastic foundation and geological conditions of the Xinhe Coal Mine, the cemented paste backfill (CPB) is proposed to prevent rockburst. In this study, the roof fracture mechanism of block caving mining (BCM) and CPB methods are established. Then, the stress evolution of the surrounding rock and the subsidence of roof strata with these two methods are compared. The results show that the maximum bending moment appears in the middle of the roof, and the value is far below the critical bending moment of the roof by using the CBP. While using the BCM, this value exceeds the critical bending moment of the roof, which may trigger rockburst-related problems. In addition, there is no first weighting and periodic weighting phenomena by using the CPB method as the overburden pressure is gradually transferred to the backfill body, resulting in a safer mining condition. Furthermore, the engineering application indicates that the frequency of daily microseismic events and the burst energy are significantly reduced by using the CPB.
Effect of Biodentine Coated with Emdogain on Proliferation and Differentiation of Stem Cells from the Apical Papilla
Authors: Karkehabadi Hamed , Ahmadyani Erfan , Najafi Rezvan , Khoshbin Elham
Published: November 2021

Background: This study assessed the effect of Biodentine coated with Emdogain (Biodentine/Emdogain) on proliferation and differentiation of stem cells from the apical papilla (SCAP). Methods and Results: In this in vitro, experimental study, SCAP were isolated from two immature impacted third molars and cultured. After ensuring the stemness of the cells by assessing their cell surface markers, they were exposed to Biodentine, Emdogain, and Biodentine/Emdogain for 24 and 72 hours. The control cells did not receive any intervention. Cell viability was evaluated by the methyl thiazolyl tetrazolium (MTT) assay. Expression of odontogenic differentiation genes was analyzed by the quantitative reverse transcription polymerase chain reaction (qRT-PCR). Alkaline phosphatase (ALP) activity was quantified by the respective kit. Data were analyzed by one-way ANOVA, t-test, and Mann-Whitney test (α=0.05). Cell viability did not change after 24 hours of exposure to biomaterials. At 72 hours, the viability of the cells exposed to Biodentine and Biodentine/Emdogain decreased compared with the control group. The expression of dentin sialophosphoprotein (DSPP), dentin matrix protein 1 (DMP1), and bone sialoprotein (BSP) genes, and ALP activity significantly increased in all three experimental groups, compared with the control group at both 24 and 72 hours; this increase was significantly greater in Biodentine/Emdogain group. The number of mineralized nodules significantly increased in all groups after 72 hours with a greater rate in Biodentine/Emdogain group.Conclusions: All biomaterials increased the differentiation of SCAP, expression of odontogenic genes, and ALP activity, but Biodentine/Emdogain was significantly more effective for this purpose.
Genotyping marker density reduction is not an effective approach in long-term prediction-based breeding of cross-pollinated crops
Authors: DoVale Julio Cesar , Carvalho Humberto Fanelli , Sabadin Felipe , Fritsche-Neto Roberto
Published: November 2021

Reductions of genotyping marker density have been extensively evaluated as potential strategies to reduce the genotyping costs of genomic selection (GS). Low-density marker panels are appealing in GS because they entail lower multicollinearity and computational time-consumption and allow more individuals to be genotyped for the same cost. However, statistical models used in GS are usually evaluated with empirical data, using "static" training sets and populations. This may be adequate for making predictions during a breeding program's initial cycles, but not for the long term. Moreover, to the best of our knowledge, no GS models consider the effect of dominance, which is particularly important for breeding outcomes in cross-pollinated crops. Hence, dominance effects are an important and unexplored issue in GS for long-term programs involving allogamous species. To address it, we employed two approaches: analysis of empirical maize datasets and simulations of long-term breeding applying phenotypic and genomic recurrent selection (intrapopulation and reciprocal schemes). In both schemes, we simulated twenty breeding cycles and assessed the effect of marker density reduction on the population mean, the best crosses, additive variance, selective accuracy, and response to selection with models (additive, additive-dominant, general (GCA), and specific combining ability (SCA)). Our results indicate that marker reduction based on linkage disequilibrium levels provides useful predictions only within a cycle, as accuracy significantly decreases over cycles. In the long-term, high-marker density provides the best responses to selection. The model to be used depends on the breeding scheme: additive for intrapopulation and additive-dominant or SCA for reciprocal.
Connection of TF and TCF4 Gene Polymorphisms with ASD
Authors: Azmerin Maria , Hussain Md. Saddam , Islam Md. Siddiqul , Aziz Md. Abdul , Moghal Md. Mizanur Rahman , Begum Mobashera , Sen Niloy , Rahman Md. Abdur , Shahriar Mohammad , Ash Ghulam Md , Islam Mohammad Safiqul
Published: November 2021

Though the prevalence of autism spectrum disorder (ASD) is increasing day by day, there is still a lack of a proper way to diagnose or prevent ASD. There is no study carried out in the Bangladeshi children with ASD to evaluate the association of Transferrin (TF) and Transcription Factor 4 (TCF4) genetic polymorphisms. This genetic association study was designed to explore the association of rs1867503 polymorphism of TF and rs9951150 polymorphism of TCF4 genes with ASD. We collected blood from 96 children with ASD and 118 healthy children of very similar age differences. Genotyping of these SNPs was performed by the PCR-RFLP method. SPSS (version 16) was used to estimate the odds ratio (OR) and their 95% confidence intervals (CI). The frequency of mutant allele G for rs1867503 and rs9951150 polymorphisms was found 48% and 44%, respectively. In our analysis, both TF and TCF4 polymorphisms showed an increased risk for the development of ASD. AG heterozygote, GG mutant homozygote, AG+GG combined genotype, and G mutant allele of TF rs1867503 showed a significantly elevated risk of ASD development (OR=3.18, p=0.0003; OR=2.62, p=0.0128; OR=2.98, p=0.0002; and OR=1.94, p=0.001, respectively). Likewise, AG heterozygote, GG mutant homozygote, AG+GG combined genotype, and G minor allele of TCF4 rs9951150 also showed a significantly elevated risk of ASD development (OR=2.92, p=0.0007; OR=2.36, p=0.0273; OR=2.72, p=0.0005; and OR=1.92; p=0.0014, respectively). Our results indicate that TF rs1867503 and TCF4 rs9951150 polymorphisms are strongly associated with the development of ASD in Bangladeshi children.
Differential Effects of Bariatric Surgery on Plasma Levels of ANGPTL3 and ANGPTL4.
Authors: Bini Simone , D’Erasmo Laura , Astiarraga Brenno , Minicocci Ilenia , Palumbo Maria , Pecce Valeria , Polito Luca , Costanzo Alessia , Haeusler Rebecca A. , Arca Marcello , Ferrannini Ele , Camastra Stefania
Published: November 2021

Introduction: Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) are regulators of triglycerides storage and utilization. Bariatric surgery (BS) determines profound changes in adipose tissue composition and energy metabolism. We evaluated the impact of BS on plasma levels of ANGPTL3 and ANGPTL4.Method: Twenty-seven morbidly obese subjects with or without type 2 diabetes (T2D) underwent Roux-en-Y gastric bypass (RYGB) and 18 patients with advanced T2D received Biliopancreatic Diversion (BPD). Fasting ANGPTLs levels, insulin sensitivity (evaluated by euglycemic hyperinsulinemic clamp), total bile acids (TBA) and free fatty acids (FFA) were measured at baseline and 1year after surgery.Results: Both surgical procedures resulted in fat mass loss, improved glucose control, and a ~2-fold increase of insulin sensitivity. ANGPTL4 levels decreased significantly with both RYGB (26.6 ± 0.6 to 24.4 ± 0.3 ng/mL, p=0.001) and BPD (27.9 ± 1.5 to 24.0 ± 0.5 ng/mL, p=0.003). In contrast, ANGPTL3 concentrations did not change after RYGB but rose following BPD (225 ± 20 to 300 ± 15 ng/mL, p=0.003). By multiple regression analysis, changes in ANGPTL4 were independently associated with those of blood glucose, p=0.0169) whereas changes in ANGPTL3 after BPD were associated with variations in FFA (p=0.008) and insulin sensitivity (p=0.0427). Discussion: Circulating ANGPTL4 is reduced by BS probably due to the loss of fat mass and improved insulin sensitivity. Conversely, ANGPTL3 levels increased after BPD, presumably because of the metabolic changes induced by the malabsorptive effect of this surgical procedure.
Characterization and Biological Activity of a Novel Exopolysaccharide Produced By Pediococcus Pentosaceus SSC-12 From Silage
Authors: Fan Yang , Li Xinqin , Tian Rong , Tang Ruxue , Zhang Jianguo
Published: November 2021

Background: The exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) are widely used in various fields because of their safety and various biological activities. In this study, we extracted and characterized the composition as well as antioxidant and antibacterial activities of EPS from Pediococcus pentosaceus SSC-12 isolated from the silage.Results: The LAB strain SSC-12 was screened and identified as Pediococcus pentosaceus, based upon 16S rDNA gene sequencing and Neighbor Joining (NJ) phylogenetic analysis. The analysis of the EPS production kinetics results of SSC-12 showed that the EPS production reached the maximum at 20 h of culture. High-performance anion exchange chromatography (HPAEC) analysis showed that the EPS produced by SSC-12 was a heteropolysaccharide comprising glucose (42.6 %), mannose (28.9 %), galactose (16.2 %), arabinose (9.4 %) and rhamnose (2.9 %). The EPS had good antioxidant activity, especially hydroxyl radical scavenging activity. When the concentration of the EPS produced by SSC-12 (SSC-12 EPS) was 10 mg/mL, its 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ability, hydroxyl radical scavenging ability, superoxide scavenging ability, and reduction ability were 77.4 %, 97.5 %, 77.5 % and 1.3, respectively. At 10 mg/mL，SSC-12 EPS completely killed Staphylococcus aureus GDMCC 1.1220 and substantially inhibited the growth of Salmonella enterica subsp. enterica GDMCC 1.345; however, it had a weak inhibitory effect on Listeria monocytogenes GDMCC 1.347. Conclusions: Due to its strong antioxidant and antibacterial properties, EPS produced by LAB strain SSC-12 have potential application as a bioactive product in the feed, food, and pharmaceutical industries.
Cost-effectiveness of using protons in breast cancer patients aiming at reducing cardiotoxicity: A risk-stratification analysis
Authors: Li Guo , Xia Yun-Fei , Huang Yi-Xiang , Okat Deniz , Qiu Bo , Doyen Jerome , Bondiau Pierre-Yves , Benezery Karen , Gao Jin , Qian Chao-Nan
Published: November 2021

Purpose

Incidental exposure of heart to ionizing irradiation is associated with an increased risk of ischemic heart disease (IHD) in breast cancer patients after radiotherapy. Intensity-modulated proton radiation therapy (IMPT) offers a promise in limiting the mean heart dose (MHD) in breast irradiation to a negligible level. However, the uncertainty in cost-effectiveness hinders its use. This cost-effectiveness analysis aims to identify patients in appropriate risk groups as targets for IMPT.
Methods

A Markov decision model was designed to evaluate the cost-effectiveness of IMPT versus intensity-modulated photon-radiation therapy (IMRT) in reducing the irradiation-related IHD risk. Baseline evaluation was performed on 50-year-old women patient without preexisting cardiac risk factor (CRF). Stratified for preexisting cardiac risk and photon MHD, cost-effective scenarios under different proton cost and willingness-to-pay (WTP) were identified for 40-, 50- and 60-year-old patients.
Results

With baseline set-ups, incremental effectiveness (IE) ranged from 0.025 quality-adjusted life-year (QALY) to 0.135 QALY when photon MHD varied from 3 to 16 Gy; IE increased from 0.043 QALY to 0.964 QALY when preexisting cardiac risk increased from the baseline level to its 10 times. IMPT was not cost-effective to patients without preexisting CRF. At the WTP of China, once proton cost reduced to $20,000, IMPT would be cost-effective to ≤ 50-year-old women patients having preexisting cardiac risk of general-population level.
Conclusion

Patient’s preexisting cardiac risk level should be a main consideration for the clinical decision of using protons; protons may become cost-effective to general-level patients if a substantial decrease in proton cost occurs in the future.
Isolation of Antibiotic-Resistant Bacteria From The Atmospheric Air In Hospital Wards And Outdoor Areas In Kuwait During Sandstorms
Authors: Shamsah Sara , Vali Leila , Al-Kayyalli Dana , Dashti Ali A.
Published: November 2021

Aim: Antibiotic resistance is a public health concern that is linked to increased mortality, morbidity, extended hospital stays, decreased productivity, and therefore, increased financial implications. The source and dissemination of antimicrobial resistance have been linked to environmental factors, including dust storms. There is clear evidence that there has been a rapid increase in temperature in the past decades which increases the risk of sandstorms in places that had never previously experienced this phenomenon. The aim of this study is to isolate medically important micro-organisms in atmospheric air samples from outdoor spaces and inside hospital wards during sandstorms and to characterize their antimicrobial sensitivity profiles to common antibiotics.Findings: Eighty-four colonies were isolated from the target sites and identified as Staphylococcus aureus, coagulase-negative Staphylococcus, Bacillus spp., Acinetobacter spp., from hospital air samples, and Pseudomonas spp., and Staphylococcus spp. from outdoor air samples. Multi-drug resistance patterns were observed for isolates obtained from both indoor and outdoor air samples. PCR showed 6.5% of S. aureus contained mecA. Conclusion: This finding supports the notion that atmospheric air during dust storms can be counted as a source of antibiotic resistant bacteria which merits more attention especially with global warming and climate change contributing to extreme weather events.
Effects of Biofilm Burkholderia Pyrrocinia JK-SH007 On The Colonization And Growth Promotion of Poplar
Authors: Fu Huanhuan , Kong Weiliang , Chen Feifei , Liu Wanhui , Xu Qianru , Wang Chaoen , Fang Xueqi , Ye Jianren
Published: November 2021

Burkholderia pyrrocinia JK-SH007 is a high-potential biological control strain. We changed the composition of medium during the fermentation of JK-SH007 cells and induced these cells to form a biofilm. In this experiment, we deeply studied the biofilm physical and chemical properties. The new fermentation process improves the colonization ability of JK-SH007 and promotes poplar growth. In addition, the biofilm bacterial concentration reached 1010 CFU/mL, the cell dry weight increased over that of a control by 3-10-fold, there was increased environmental stress resistance and IAA secretion, and progeny cells retained resistance to adverse environments. The new biofilm cells were applied to poplar. The JK-SH007 colonization ability was improved in the biofilm, and some bacteria existed as biofilms (cell clusters) in poplar, which would promote forming a dominant niche. Biofilm JK-SH007 has an increased affinity for poplar during colonization and promotes poplar growth under hydroponic conditions, proving the reliability of the new morphology for treating poplar ulcer disease. This work further provides a theoretical basis for commercially producing JK-SH007.
Citrus Peels Phenolic Derivatives Alleviate Benzo[α]pyrene-Induced Inflammatory Injury of Human Intestinal Epithelial Cells Through NLRP3 and AhR Signaling Pathways
Authors: Liang Zhuwei , Wang Huailing , Luo Dan , Liu Xiaoyu , Liu Jie
Published: November 2021

Benzo[α]pyrene (BaP) is ubiquitous in foods, and possesses a fatal cytotoxicity. In current study, ten Citrus peels (Chenpi) phenolic derivatives (CPDs) were isolated in a cell model of human intestinal epithelial (Caco-2) cells under BaP-exposure by a bio-assay guided method. Among them, methyl (3,4,5-trimethoxybenzoyl) valylphenylalaninate (Citrus peels phenolic derivative-2, CPD-2) performed the most protective activity by promoting the antiinflammatory potential on BaP-induced Caco-2 cells. CPD-2 inhibited BaP-induced intracellular ROS over-production and inflammatory epithelial cytokine, IL-4, IL-8, TNF-α, IL-1β and IL-18 over-expression, but not IL-6. CPD-2 also inhibited BaP-induced NLRP3 inflammasome and AhR signaling pathway activation. Overall, CPD-2 attenuates BaP-induced apoptotic death via promoting the antiinflammatory potentials by inhibiting the NLRP3 and AhR signaling pathways activation of Caco-2 cells. Finally, the Citrus peels phenolic derivatives was observed for the first time against BaP-induced inflammation and oxidative stress in human intestinal epithelial cells.
ColabFold - Making protein folding accessible to all
Authors: Mirdita Milot , Schütze Konstantin , Moriwaki Yoshitaka , Heo Lim , Ovchinnikov Sergey , Steinegger Martin
Published: November 2021

ColabFold offers accelerated protein structure and complex predictions by combining the fast homology search of MMseqs2 with AlphaFold2 or RoseTTAFold. ColabFold's 20-30x faster search and optimized model use allows predicting thousands of proteins per day on a server with one GPU. Coupled with Google Colaboratory, ColabFold becomes a free and accessible platform for protein folding. ColabFold is open-source software available at github.com/sokrypton/ColabFold. Its novel environmental databases are available at colabfold.mmseqs.com.
Validity and Application of a Portable Force Platform in Assessment of Dynamic Balance Ability
Authors: Lin Jinpeng , Wang Fang , Zhao Yaqi , Li Junjie , Li Jixin , Tian Fei , Zhai Hua , Wang Shaobai
Published: November 2021

Background: Dynamic balance assessment, which requires a specialized device, is crucial in clinic to evaluate postural control comprehensively. The Nintendo Wii Balance Board (WBB), a portable force platform may be a suitable alternative to the expensive “gold standard”- the laboratory-grade force platform (FP). However, its validity in assessment of dynamic balance is still unclear. The purpose of this study is to demonstrate the validity of the WBB in dynamic balance assessment.Methods: We performed three static and dynamic balance tests, including open eyes single-leg stand, close eyes single-leg stand and Limitation of Stability, on the WBB for 34 healthy participants. Trajectories of center of pressure (COP) were recorded synchronously and used to compute seven characteristics. To quantify the consistency of the two devices, we used intraclass correlation coefficient (ICC) as well as visual evaluation of Bland–Altman plots.Results: The data showed a high consistency between the two devices (ICC = 0.92-0.98) under static and dynamic balance assessments, and the visual evaluation result from Bland–Altman plot was acceptable between device agreement. Moreover, in the dynamic balance task (Limitation of Stability test), the typical ranges of COP-based postural sway distances for healthy adults in medial-lateral and anterior-posterior measured by the WBB were 27.17 ± 3.88 cm and 21.13 ± 2.33 cm, respectively, indicating the validity of the WBB in assessing COP under both static or dynamic balance tasks. Conclusion: With the advantages of portability and low-cost, the valid WBB can facilitate the popularization of quantitative balance evaluation to basic hospitals. Our results provide valuable reference for clinical evaluation of balance ability.
Factors Associated With Low Back Pain In Patients With Lumbar Spinal Stenosis: A Cross-Sectional Study
Authors: Ogon Izaya , Iba Kousuke , Takashima Hiroyuki , Terashima Yoshinori , Yoshimoto Mitsunori , Emori Makoto , Teramoto Atsushi , Takebayashi Tsuneo , Yamashita Toshihiko
Published: November 2021

Background: Low back pain (LBP) is a major symptom of lumbar spinal stenosis (LSS). To develop better treatment, it is important to assess LBP in patients with LSS. This study aimed to analyze the factors associated with LBP in patients with LSS.Methods: This cross-sectional study included consecutive patients with LSS aged between 51 and 79 years who had symptoms in one or both legs with or without LBP. The participants were classified into two groups: the high group (LBP visual analog scale [VAS] score of 30 mm or more) and the low group (LBP VAS score of less than 30 mm). We performed multiple logistic regression analysis with the high and low groups as dependent variables and a receiver operating characteristic (ROC) analysis.Results: A total of 80 patients with LSS were included (35 men and 45 women; mean age 64.5 years), with 47 and 30 patients in the high and low groups, respectively. Multivariate logistic regression analysis revealed that the sagittal vertical axis (SVA; + 1; odds ratio [OR], 1.029; 95% confidence interval [CI], 1.005−1.052) and pelvic incidence (PI)-lumbar lordosis (LL; + 1; OR, 1.065; 95% CI 1.019–1.168) were significantly associated with LBP. ROC analysis revealed cut-off values of 47.0 mm and 30.5° of PI-LL, respectively.Conclusion: These cut-off values could have a high specificity and positive predictive value for LBP in patients with LSS due to spinopelvic malalignment. However, these cut-off values could also represent with a cause other than LSS due to spinopelvic malalignment.