bluuebunny/crossref_metadata_2025 huggingface dataset:
Service Quality, Brand Attributes, Satisfaction and Loyalty of Guests Staying at Le Meridien Hotel Bali Jimbaran
Authors: Dewi Luh Putu Triyanti Ariestiana , Wiranatha Agung Suryawan , Suryawardani I Gusti Ayu Oka
Published: April 2021

Guest satisfaction and loyalty become an indicator of the success of a hotel. Service quality and brand attributes are two components that related the satisfaction and loyalty of guests who stay at the hotel. The purposes of this study were 1) To analyse the relationship of service quality and brand attributes to the satisfaction of guests staying at the Le Meridien Bali Jimbaran hotel, 2) To analyse the relationships of service quality and brand attributes to the loyalty of guests staying at the Le Meridien Bali Jimbaran hotel, 3) To analyse the satisfaction of the guests staying at the Le Meridien Bali Jimbaran hotel. This research used quantitative method involving 100 guests who stayed overnight as the respondents. Sampling was done by accidental sampling and analysis using Structural Equation Model (SEM) with SmartPLS 3.0 software. The results showed that 1) Service quality had a significant effect on satisfaction, 2) Service quality had no significant effect on loyalty, 3) Brand attributes had a significant effect on satisfaction, 4) Brand attributes had significant influence on loyalty, and 5) Satisfaction has a significant effect on loyalty. Suggestions that can be made in this study that hotel should support loyalty, maintain and pay close attention to brand attributes that need to be improved and guest mindset influence, as well as the should find other aspects that can support and increase guest loyalty.
The Role of Social Capital in Serangan Sub-District, Denpasar-Bali
Authors: Nugraha I Gede Putra , Antara I Made , Budiarsa Made , Paturusi Syamsul Alam
Published: April 2021

Serangan sub-district as a potential area is a representation of Denpasar City Government’s policy on environmental conservation, historical and cultural values, the interests of the world of education, and the interests of cultural tourism full of attractions. The purpose of this study is to identify the role of social capital in the development of sustainable tourism in the Serangan Sub-District and to analyze the effect of government roles, community participation, and social capital on destination quality and sustainable tourism development in the Serangan sub-district. The result of this research shows that social capital norms in the Serangan sub-district has an important role in tourism development in the Serangan sub-district, where the norms in traditional villages in the Serangan sub-district are still very strong.
Herramienta de comunicación para personas con discapacidad.
Authors: Isgro Christine Adriane , Pérez Adriana Inés , Fernández Patricia M. , Rodríguez Ana Nieves
Published: April 2021

Es muy común la aparición de problemas serios de visión en personas mayores, que les impiden continuar con una vida independiente, requiriendo la compañía y asistencia permanente de cuidadores. Este trabajo en particular fue motivado por la cercanía del equipo de trabajo con una familia compuesta por una señora viuda, de 92 años y su hijo de 52 años, persona con Síndrome de Down, con comorbilidades derivadas que requiere acompañamiento continuo. La señora desarrolló por su edad una enfermedad en la mácula que redujo significativamente su visión y deterioró su calidad de vida. Una de las consecuencias inmediatas fue la imposibilidad de realizar llamadas telefónicas para comunicarse con familiares y/o solicitar el envío de mercadería o medicamentos. La situación antes expuesta motivó la búsqueda de una aplicación en el celular en la cual las órdenes de las llamadas se realicen a través de comandos de voz. Se analizaron los asistentes de voz para celulares con sistema operativo Android y al no encontrar uno que resulte adecuado, se desarrolló una herramienta que facilitó la comunicación a los miembros de la familia mencionada. Esperamos que en el futuro esta aplicación sea una solución para personas con discapacidad visual o intelectual.
Editorial
Authors: Espinel Blanca
Published: April 2021

La revista científica Teknos, de la Fundación Universitaria Tecnológico Comfenalco, tiene como objeto despertar el interés por el desarrollo de la ciencia y estimular la producción científica en la tanto en la academia como en la industria. Ahora más que nunca este propósito sigue vigente, si tenemos en cuenta que, dentro del contexto de la Era digital, se facilita el acceso al conocimiento generado a escala global.

Por lo tanto, la revista Teknos presenta ante la comunidad científica nacional e internacional en su último número, artículos escritos por investigadores y docentes universitarios en diversas temáticas, cuyo propósito es el loable esfuerzo de difundir sus hallazgos, reflexiones, sistematizaciones de experiencias o revisiones de la literatura académica.
PENERAPAN SISTEM PENANAMAN JAJAR LEGOWO MELALUI PEMBERIAN RHIZOBAKTERI UNTUK PERTUMBUHAN DAN PRODUKSI PADI
Authors: Yanti Yulmira , Hamid Hasmiandy , Yaherwandi Yaherwandi , Hermeria Noveriza
Published: April 2021

Kabupaten Tanah Datar merupakan daerah agraris, lebih 70% penduduknya bekerja pada sektor pertanian, baik pertanian tanaman pangan, perkebunan, perikanan, maupun peternakan. Nagari Gunung Rajo merupakan salah satu nagari di Kecamatan Batipuh dengan pertanian sebagai sektor ekonomi utama yaitu tanaman padi sawah. Masalah yang sering dihadapi petani Gunung Rajo adalah masalah hama dan penyakit yang menyerang tanaman. Salah satu komponen utama dari program PHT adalah pengendalian hayati dengan memanfaatkan agen hayati rizobakteri indigenus. Aplikasi rizobakteri sangat menguntungkan bagi tanaman karena dapat mempengaruhi pertumbuhan tanaman secara langsung dan tidak langsung. Tujuan kegiatan pemberdayaan kelompok tani ini adalah untuk menambah pengetahuan masyarakat mengenai pemanfaatan rizobakteri yang dapat meningkatkan pertumbuhan dan hasil produksi tanaman padi dengan sistem tanam jajar legowo. Metode yang digunakan dalam kegiatan ini yaitu dengan pelatihan terstruktur dan praktik langsung dilapangan pengaruh rizobakteri terhadap pertumbuhan dan produksi tanaman padi menggunakan sistem jajar legowo. Hasil yang diperoleh dari kegiatan ini yaitu produksi bobot gabah/rumpun tanaman yang diberi perlakuan rizobakteri lebih tinggi sebanyak 40,74 gram dibandingkan dengan tanaman yang tidak diberi perlakuan rizobakteri (tanaman kontrol). Kesimpulan dari kegiatan ini yaitu pertumbuhan dan hasil produksi tanaman yang di aplikasikan menggunakan rizobakteri lebih tinggi dari pada tanaman yang tidak diberi perlakuan rizobakteri. Penggunaan rizobakteri sangat disarankan karena selain mudah untuk didapatkan juga memberikan nilai positif terhadap pertumbuhan tanaman dan baik untuk teknologi lingkungan sekitar tanaman budidaya.
PENERAPAN LEARNING MANAGEMENT SYSTEM MELALUI MODUL DIGITAL, WORKSHOP, DAN PENDAMPINGAN DI MASA PANDEMI COVID-19
Authors: Albar Berri Brilliant
Published: April 2021

Perguruan tinggi perlu mempersiapkan pembelajaran daring sebagai jawaban atas tantangan kebutuhan revolusi industri 4.0. Selain itu, permasalahan eksternal bertambah di tahun 2020, salah satunya pemunculan virus corona yang menjadi pandemi. Situasi pandemi memaksa perguruan tinggi untuk segera beradaptasi di dalam kegiatan pembelajaran. Keputusan Menteri Pendidikan dan Kebudayaan adalah melanjutkan kegiatan pelaksanaan pendidikan jarak jauh (PJJ) secara daring hingga batas waktu yang tidak ditentukan. Situasi tersebut memunculkan beberapa permasalahan pada perguruan tinggi, diantaranya kesiapan sumber daya manusia, fasilitas, dan lainnya. Seiring berjalannya waktu, perkuliahan sudah dimulai, maka permasalahan ini harus segera diatasi agar tercapainya tujuan pembelajaran dan peningkatan kualitas pendidikan pada perguruan tinggi di saat krisis seperti sekarang ini. Peningkatan penguasaan LMS oleh dosen dan penyediaan modul dan standarisasi estetika merupakan salah satu upaya penyelenggara pendidikan untuk menyampaikan pelayanan yang berkualitas (reliability, assurance, tangible, empathy, dan responsiveness) dan memuaskan bagi penerima layanan (masyarakat/ mahasiswa). Kegiatan ini berhasil melaksanakan workshop teknis dan modul yang efisien dan efektif untuk peningkatan pemahaman penguasaan LMS dalam waktu singkat.
PENERAPAN TEKNOLOGI SILASE JERAMI JAGUNG SEBAGAI PAKAN TERAK DI OPHIR NAGARI KOTO BARU KABUPATEN PASAMAN BARAT
Authors: Syaiful Ferry Lismanto , Utami Yayuk Sri
Published: April 2021

Pakan merupakan suatu kebutuhan yang mutlak harus diperhatikan dalam pemeliharaan ternak. Umumnya di musim kemarau, peternak terkendala dalam ketersediaan pakan sulit didapatkan. Disisi lain, Pada saat musim panen jagung di Jorong Ophir Nagari Koto Baru Kabupaten Pasaman Barat ketersediaan jerami jagung sangat melimpah. Jerami jagung sangat berpotensi sebagai sumber pakan, namun pemanfaatannya belum optimal dikarenakan kualitasnya masih rendah. Untuk peningkatan kualitas dan manfaat jerami jagung ini maka diperlukan petani sebuah teknologi yang mudah dan sederhana untuk peningkatan kualitas pakan diantaranya teknologi silase jerami jagung. Tujuan kegiatan ini yaitu untuk peningkatan pengetahuan dan keterampilan peternak dan petani atau masyarakat Jorong Ophir Nagari Koto Baru dalam penerapan teknologi pembuatan silase jerami jagung sebagai pakan ternak. Kegiatan pelatihan dilakukan Jorong Ophir yang melibatkan petani peternak dan masyarakat. Metode kegiatan berupa penyuluhan, pelatihan dan evaluasi. Pada kegiatan ini terlihat peserta antusias mengikuti pelaksanaan kegiatan. Setelah pelaksanaan kegiatan ini terlihat adanya peningkatan pengetahuan dan pemahaman masyarakat dalam penerapan pembuatan silase jerami jagung sebagai pengolahan pakan ternak. Hal ini tentunya peternak dapat mengotimalisasi limbah sebagai pakan ternak yang harga yang relatif murah. Berharap dari kegiatan ini adanya keberlanjutan program yang dilakukan peternak agar optimalisasi pakan yang berkualitas untuk peningkatan produktivitas ternak.
Antibacterial effect of Artemisia and ginger extracts in controlling Agrobacterium tumefaciens in roses
Authors: Njagi Alfred , Mang'erere Methuselah Nyamwange , Njeru Ezekiel Mugendi , Birgen Jonah Kiprono
Published: April 2021

Rose is the world’s most traded cut flowers with 74 % being produced in Kenya. Pests like spider mites, caterpillar, aphids, thrips, nematodes and diseases such as crown gall, downy mildew, powdery mildew and botrytis highly compromise rose production. Crown gall disease caused by Agrobacterium tumefaciens is the most problematic disease of roses in Kenya, causing a production loss of up to 60 % depending on the age and variety of rose. An experiment to determine the antibacterial effect of Artemisia and ginger extracts was carried out in vitro, where the inhibitory zones around filter discs soaked with extracts on Muller Hinton agar was established. The extracts were emulsified with dimethylsulfoxide (50 %) and minimum inhibitory concentrations of Artemisia (125 mg/ml), ginger (62.5 mg/ml) and mixture of Artemisia and ginger (31.25 mg/ml) were used to soak the filter discs whereas the commercial recommended rate of copper hydroxide of 6.25 mg/ml was used. Artemisia and copper hydroxide (commercial antibiotic) had highest inhibition zone of 12.80 mm compared to ginger 10.60 mm. A mixture of Artemisia and Ginger had a slightly lower inhibition zone (10.20 mm) though not significantly different from ginger (P> 0.001). An eight-month greenhouse experiment was also done to determine the efficacy of the extracts on inoculated rose plants. The results showed that crown gall incidence and gall weight were low but not significantly different from copper hydroxide and Artemisia. Crop vigor, which was indicated by stem length was highest for Artemisia treatment with an average of 73.54 cm followed by copper hydroxide (67.25 cm) while ginger and mixture of ginger and Artemisia had 53.44 cm and 64.70 cm respectively. From the results of this research, Artemisia and Ginger extracts are promising alternative to control crown gall and possibly other diseases in field crops. Artemisia performance compares well with copper hydroxide and therefore the best alternative to replace copper hydroxide.
PENGARUH KOMPENSASI EKSEKUTIF TERHADAP MANAJEMEN LABA DENGAN PROFITABILITAS SEBAGAI VARIABEL MODERATING (STUDI EMPIRIS PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA)
Authors: Vania Donela Helisa Noviarty,
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh kompensasi eksekutif terhadap manajemen laba dan pengaruh kompensasi eksekutif terhadap manajemen laba yang dimoderasi oleh profitabilitas. Teknik pemilihan sampel yang digunakan yaitu purposive sampling dan diperoleh sebanyak 31 perusahaan perbankan yang terdaftar di Bursa Efek Indonesia di masa pengamatan pada tahun 2016-2018. Metode analisis dalam penelitian ini adalah analisis regresi sederhana. Hasil penelitian ini menunjukkan bahwa tidak terdapat pengaruh kompensasi eksekutif terhadap manajemen laba dan tidak adanya moderasi profitabilitas dalam pengaruh kompensasi eksekutif terhadap manajemen laba.  Kata Kunci : Manajemen Laba, Profitabilitas, Kompensasi Eksekutif
ANALISIS FAKTOR-FAKTOR PENERIMAAN PENGGUNAAN APLIKASI ANDROID BOOK KEEPER ACCOUNTING DENGAN PENDEKATAN TECHNOLOGY ACCEPTANCE MODEL PADA UMKM DI KOTA PONTIANAK
Authors: Karpriana Angga Permadi
Published: April 2021

Penggunaan aplikasi Android Book Keeper Accounting diharapkan dapat membantu pemilik UMKM di Kota Pontianak dalam mengelola keuangan. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi pemilik UMKM di Kota Pontianak untuk berminat menggunakan aplikasi Android Book Keeper Accounting. Technology Acceptance Model (TAM) digunakan sebagai model untuk menguji penerimaan teknologi aplikasi Android Book Keeper. Metode penelitian ini menggunakan survey dengan teknik pengambilan sampel 100 responden mewakili tiap-tiap kecamatan di Kota Pontianak. Hasil  analisis data enelitian diperoleh hasil sebagai berikut: (1)  Konstruk perceived ease of use (PEOU)  mempengaruhi konstruk perceived usefulness (PU); (2)  Konstruk PU mempengaruhi konstruk attitude towards behavior (ATB); (3)  Konstruk perceived ease of use (PEOU) mempegaruhi terhadap konstruk attitude towards behavior (ATB); (4) Konstruk PU mempengaruhi terhadap  konstruk behavior intention (BI); (5)  Konstruk attitude towards behavior (ATB) tidak memiliki pengaruh terhadap konstruk behavior intention (BI). Faktor-faktor pendorong konstruk attitude towards behavior (ATB) masih kurang kuat sehingga tidak berpengaruh terhadap minat perilaku pemilik UMKM untuk menggunakan aplikasi Android Book Keeper Accounting.Kata Kunci : Technology Acceptance Model (TAM), Book Keeper Accounting,pemilik UMKM
PERBANDINGAN KINERJA KEUANGAN DAN KEBIJAKAN AKUNTANSI PADA PT TELKOM Tbk DAN PT INDOSAT Tbk
Authors: Noviarty Helisa , Effendi Ervin
Published: April 2021

This Penelitian ini bertujuan mengetahui perbedaan kinerja keuangan dan kebijakan akuntansi antara PT Telkom Tbk dengan PT Indosat Tbk. Bentuk penelitian yang digunakan dalam penelitian ini adalah comparative research atau penelitian komparatif dengan pendekatan kuantitatif dan kualitatif. Adapun alat analisis kinerja keuangan perusahaan yang digunakan yakni rasio Profitabilitas dan Economic ValueAdded (EVA) sedangkan perbedaan kebijakan akuntansi berdasarkan analisa pengakuan pendapatan dan biaya yang diterapkan oleh kedua perusahaan. Hasil penelitian menunjukkan bahwa terdapat perbedaan kinerja keuangan antara PT Telkom Tbk dan PT Indosat Tbk sedangkan pada kebijakan akuntansi tidak terdapat perbedaan antara kedua perusahaan berdasarkan analisa pengakuan pendapatan dan biaya.Keywords: Profitabilitas, Economic Value Added (EVA)
VOLUNTEERING IN RUSSIAN REGIONS: SOCIOPSYCHOLOGICAL FEATURES, PROBLEMS OF REALIZATION AND ITS SOLUTION
Authors: Filippova T. I. , Khachikyan E. I. , Patsakula I. I. , Ivanona I. V.
Published: April 2021

Volunteering, as a relatively new form of manifesting social activity, but in demand in society, requires a comprehensive study. The main purpose of this research is assessment of socio-psychological features of volunteer activities and the problems of its implementation in the regions of Russia, including in conditions of increased social tension caused by the coronavirus pandemic. The article presents the results of the interregional sociological Internet survey of volunteers conducted by the authors (on the example of the regions of the Central Federal District of the Russian Federation). Their analysis made it possible to obtain new evaluation and analytical information about the phenomenon being studied, to expand ideas about modern trends in the development of volunteering, including in the current situation of social tension; determine the vector of solving the existing problems in this area. Based on the results of the study, the authors propose practical recommendations to increase the effectiveness of volunteer activities in the regions, which can be integrated into the processes of making political and organizational and methodological decisions.
FUZZY LOGIC APPARATUS AS A TOOL FOR ASSESSING THE EFFECTIVENESS OF DIGITALIZATION OF A COMPANY
Authors: Kokhanova V. S.
Published: April 2021

In this article, the author gives an example of using the apparatus of fuzzy logic in assessing the effectiveness of digitalization of an enterprise, specifies indicators that can be used as criteria for building a system for assessing the effectiveness of digitalization, as well as provides an overview of existing developments. Within the framework of the article, the study outlines the directions of modification of classical estimation methods that are possible using the apparatus of fuzzy logic. The paper substantiates the choice of a universal fuzzy logic tool as a mathematical apparatus for forming an assessment: a system of fuzzy logical conclusions – standard five-level [0; 1]-classifiers. The possibility of fuzzy classification of properties, as well as qualimetry based on the aggregation of hierarchies of factors, will make it possible to assess the level of efficiency of enterprise digitalization by the degree of success.
ORGANIZATIONAL AND ECONOMIC MECHANISM FOR IMPROVING THE QUALITY OF HUMAN RESOURCES OF THE REGION
Authors: Ostapenko E. A.
Published: April 2021

The quality of human resources, considered as a set of certain assessment criteria that are dynamic in nature, due to the basic indicators and factors of the internal and external environment of the social and economic system of the region needs a comprehensive management impact aimed at improving the system and its elements. The quality of human resources in socio-economic systems, as well as tools aimed at the formation of qualitative parameters, form the problem of improving the economic mechanism for improving the quality of human resources in modern conditions, which should take into account the management goals, the state and prospects for the development of quality parameters of the system elements, to ensure the effective functioning of the conceptual model of quality management of human resources.
Morphobiological characteristics and taxonomic status of weather loaches (Misgurnus) in the Pad Bolshaya (Middle Amur River)
Authors: Ostrovskaya E. V. , Kasatkina A. P.
Published: April 2021

Morphological signs (32 plastic and 7 meristic) and biological parameters (size, weight, age and sexual structure, fecundity) are considered for weather loaches of gen. Misgurnus inhabiting the Pad Bolshaya (Jewish Autonomous oblast), with the body length Ad 60.2-182.4 mm, body weigh 2.3-55.3 g, age 1-8 years and sex ratio about 1 : 1 (53 % males, 47 % females). Sexual dimorphism is found for antedorsal, anteventral and ventroanal distances, tail fin base length, base length and height of pectoral, pelvic and anal fins, and maximum body height. Ontogenetic variability of morphological indices in dependence on body length is detected for 26 of 32 plastic signs, whereas the dependence of anteanal, antedorsal, pectoventral, and anteventral distances, and maximum and minimum body height on the body length is not statistically significant. Males grow slower than females. Age of puberty is 4-6 years, mean individual absolute fecundity is 7409 eggs. The analysis concluded that the weather loaches Misgurnus in the Pad Bolshaya belonged to the species Misgurnus nikolskyi (Vasil’eva, 2001).
Effect of estradiol on gonads development for resident form males of cherry salmon Oncorhynchus masou
Authors: Zelennikov O. V. , Myakishev M. S. , Vorojtsova A. A.
Published: April 2021

Effect of estradiol on development of gonads in resident form males of cherry salmon is investigated. The fish aged 0+ with initial weight of 3.48-10.70 g were treated with the hormone for 30 days, then reared for 8 months. Estradiol was given with pelleted food in concentration of 100 mg/kg. The gonads were examined histologically during entire period of the experiment. The control group included 184 specimens (90 females, 59 anadromous males and 35 males of resident form). The experimental group of 50 females and 48 males was taken randomly in 3.5 months after the end of hormonal exposure. The fund of germ cells in gonads of the experimental group consisted only of gonias. Males of resident form were identified in 6 and 8 months after the end of hormonal exposure, they were distinguished by both size of the testes and presence of germ cells at different stages. Portion of the males of resident form was similar in the control and experimental groups — 37.0 % and 40.7 % of total number of males, respectively.
Methodological aspects of the stock-recruitment curve analysis
Authors: Ostrovsky V. I.
Published: April 2021

Choosing of mathematical model for describing of the pacific salmon progeny dependence on the parents abundance is discussed. Results of different approximations are interpreted. The analysis could be useful for forecasting of the pacific salmon stocks by specialists without deep skills in numerical modeling (like the author).
Modern state of stocks for demersal and pelagic fishes on the shelf of Olyutorsky-Navarin area
Authors: Savin A. B.
Published: April 2021

Stocks of demersal and pelagic fish species are assessed for the bottom layer over the outer shelf and upper continental slope between Cape Olyutorsky and Cape Navarin (northwestern Bering Sea) on the data of bottom trawl survey conducted aboard RV Professor Levanidov over the isobaths 20-400 m in the summer of 2019. The total biomass of demersal fish in the surveyed polygon was estimated as 682,262 t; the portion of pacific cod was 51.50 %, arrowtooth flounder — 9.80 %, great sculpin — 9.64 %, rock sole — 4.60 %, alaska skate — 4.57 %, flathead flounders — 2.56 %, yellow irish lord — 2.30 %, and < 2 % for other species. The total biomass of pelagic fish species in the bottom layer was estimated as 759,639 t (species-specific coefficients of catchability were used); the portion of adult walleye pollock was 85.12 %, its juveniles — 9.94 %, pacific herring — 4.67 %, and other pelagic species — 0.27 % in sum. Mean ratios of the species stock between the surveyed polygon and other areas of the northwestern Bering Sea, as the Gulf of Anadyr and the deeper continental slope (below 400 m), were evaluated using the data of bottom trawl surveys conducted in 2005-2017. Some species as yellow irish lord, saffron cod, pacific halibut, arrowtooth flounder, great sculpin, kamchatka flounder, rock sole, and aleutian skate distributed mostly within the polygon and their mean biomass in the outside areas varied from 0.5 % to 69.2 % relative to the biomass in the polygon surveyed in 2019. On the contrary, the portions of pacific cod, greenland halibut, alaska skate, and walleye pollock were larger outside the polygon — from 102.9 to 190.4 %, and almost entire stocks were in the outside areas for alaska plaice, flathead flounders, and pacific herring — from 533.4 % to 1380.5 % relative to the biomass accounted within the polygon. The stocks assessed in 2019 reflected both the state of populations and their spatial and bathymetric redistribution, mostly because of the St. Lawrence Cold Water Pool shrinkage at the bottom of the Gulf of Anadyr. The stocks fluctuations are reasoned mainly by natural factors, rather than fishery impact.
A Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases
Authors: Shen Ruidan , Crean Rory , Johnson Sean , Kamerlin Shina Caroline Lynn , Hengge Alvan C.
Published: April 2021

Catalysis by protein tyrosine phosphatases (PTPs) relies on the motion of a flexible protein loop (the WPD-loop) that carries a residue acting as a general acid/base catalyst during the PTP-catalyzed reaction. The orthogonal substitutions of a non-catalytic residue in the WPD-loops of YopH and PTP1B results in shifted pH-rate profiles, from an altered kinetic pKa of the nucleophilic cysteine. Compared to WT, the G352T YopH variant has a broadened pH-rate profile, similar activity at optimal pH, but significantly higher activity at low pH. Changes in the corresponding PTP1B T177G variant are more modest and in the opposite direction, with a narrowed pH profile and less activity in the most acidic range. Crystal structures of the variants show no structural perturbations, but suggest an increased preference for the WPD-loop closed conformation. Computational analysis confirms a shift in loop conformational equilibrium in favor of the closed conformation, arising from a combination of increased stability of the closed state and destabilization of the loop-open state. Simulations identify the origins of this population shift, revealing differences in the flexibility of the WPD-loop and neighboring regions. Our results demonstrate that changes to the pH dependency of catalysis by PTPs can result from small changes in amino acid composition in their WPD-loops affecting only loop dynamics and conformational equilibrium. The perturbation of kinetic pKa values of catalytic residues by non-chemical processes affords a means for nature to alter an enzyme’s pH dependency by a less disruptive path than altering electrostatic networks around catalytic residues themselves.
Conversion of Wood into Hierarchically Porous Charcoal in the 200-Gram-Scale Using Home-Built Kiln
Authors: Leonel Long , Arnal Pablo
Published: April 2021

Wood-to-charcoal is crucial in developing new materials at the lab-scale for relevant applications, such as pollutant removal from water. Unfortunately, laboratory carbonization methods are costly and produce charcoal on the gram-scale. This work presents a simple-to-build and simple-to-operate home-made kiln that carbonizes Eucalyptus wood chips (yield of 30 ± 1%) and produces charcoal on the 200-gram scale. Solid particles had the typical structure, composition, and chemical behavior of charcoal obtained from wood. We believe that his carbonization process eases the charcoal synthesis required for the development of new charcoal-based materials.
Kinetic Modeling of API Oxidation: 1. The AIBN/H2O/CH3OH Radical "Soup"
Authors: Grinberg Dana Alon , Wu Haoyang , Ranasinghe Duminda , C. Pickard IV Frank , P. F. Wood Geoffrey , Zelesky Todd , Sluggett Gregory W. , Mustakis Jason , Green William H.
Published: April 2021

While different flavors of API stress testing systems have been used in experimental investigations for decades, the detailed kinetics of such systems as well as the chemical composition of prominent reactive species, specifically reactive oxygen species, are unknown.

As a first step toward understanding and modeling API oxidation in stress testing, we investigated a typical radical "soup" solution an API is subject to during stress testing.

Here we applied ab-initio electronic structure calculations to automatically generate and refine a detailed chemical kinetics model, taking a fresh look at API oxidation.

We generated a detailed kinetic model for a representative azobisisobutyronitrile (AIBN)/H2O/CH3OH stress-testing system with varied co-solvent ratio (50%/50% -- 99.5%/0.5% vol. water/methanol) and for representative pH values (4--10) at 40oC stirred and open to the atmosphere.

At acidic conditions hydroxymethyl alkoxyl is the dominant alkoxyl radical, and at basic conditions, for most studied initial methanol concentrations, cyanoisopropyl alkoxyl becomes the dominant alkoxyl radical, albeit at an overall lower concentration.

At acidic conditions the levels of cyanoisopropyl peroxyl, hydroxymethyl peroxyl, and hydroperoxyl radicals are relatively high and comparable, while at both neutral and basic pH conditions, superoxide becomes the prominent radical in the system.

The present work reveals the prominent species in a common model API stress testing system at various co-solvent and pH conditions, sets the stage for an in-depth quantitative API kinetic study, and demonstrates usage of novel software tools for automated chemical kinetic model generation and ab-initio refinement.
The Use of Zeolite-Based Geopolymers as Adsorbent for Copper Removal from Aqueous Media
Authors: Baykara Haci , Mendoza Solorzano Maria de Lourdes , Delgado Echeverria Jose Javier , Cornejo Mauricio H. , Tapia-Bastidas Clotario V.
Published: April 2021

In this study the use of a natural zeolite-based geopolymer use in removal of copper from aqueous media has been presented for the first time. Additionally, kinetics and isotherms of the adsorption have also been demonstrated.
Development and Validation of a Ultra Flow Liquid Chromatography Method for the Assay of Boceprevir Using a Quality-by-Design Approach
Authors: Manish Majumder  , Ramesh B  , Minaketan Tripathy
Published: April 2021

Quality by design guided. The assay method of Boceprevir is developed in accordance with ICH Q8(R2) guideline with due validation. .In this process, the Target analytical profile (TAP) of the drug was set and critical method parameters (CMP) were investigated by systematic risk assessment experimentation to control critical Quality Attributes (CQA). In this, A Cause Effect Risk Assessment Matrix with Control-Noise-Experiment (CNX) is used for identifying the high-risk variables i.e Percentage of Organic Modifier (% methanol), pH of the Buffer and flow rate of the mobile phase. The surface response methodology was applied to optimize the critical method parameters (CMP) as well as Critical Quality Attributes (CQA) to find out the Design space of the method. The Optimum assay method condition was mobile phase Acetate Buffer (50mM) pH 5.4: Methanol (11:89), Flow rate: 0.9 ml/min, Lambda Max: 207. The separation was achieved in the Eclip Plus C-18 column (250 × 4.6 mm, 5μm) at ambient temperature. The retention time of Boceprevir was found to be 4.2 min. The method evaluation was performed according to the (Q2R1) ICH guideline.
Estimate the Heterosis in F1 for Vicia Faba Plant
Authors: Israa M. M. A. Agwan
Published: April 2021

This study included six parent (1) FLIP11-092FB, (2) FLIP11-088FB, (3) FLIPO6-016FB, (4) FLIPO6-005FB, (5) France, (6) Line 46-01 in the station of field crops department –faculty of agriculture and forests-university of Mosul during the growth season 2012-2013 method _1_in program. executed the study lead to evaluation the average of parents performs and choice the different single hybrid from the field and productive performance and the genetic differences between the studied traits   as well as estimate the heterosis by the deviation the hybrid of F1about the best parent for the fifteen characters. Parent and the hybrid showed the significant different from some quantitative characters and the heritability from the different characters and specifically the coefficient of genotypic and phenotypic variation and the expected genetic improvement by the percentage the parent (1) dusting unshed by highest value in the number of knead and flower and harvest index and weight of 100seeds and the parent (2) for the number of flowering days and the high plant and the total number of branches in the plant and total number of pods. The parent (4) for the weight and the rate and the number of pods in plant and the biological yield. The comparison among some of hybrids such as hybrid (3*5)have a high value of high plant and pod and number seed in pod and green yield per plant comparison by another hybrid.
A novel stability indicating RP-HPLC Method for the estimation of ulipristal - A Selective Progesterone Receptor Modulator
Authors: Sundeep Kumar HK  , Bhabani Sankar Sahoo  , Biswanath Mishra
Published: April 2021

The present research article described the novel HPLC technique that was developed for the estimation of ulipristal  in an API and tablet formulation. Symmetry, C18, 250mm x 4.6mm .i.d., 5 µm Particle size, column with 0.4 ml/min flow rate, was used for the chromatographic separation. Phosphate buffer, pH 4.6 and methanol as a mobile phase (20:80) with a flow rate of 1 mL/min and eluent at 304 nm was monitored for the mobile phase. In compliance with ICH guidelines, the method was validated. Ulipristal was eluted in this technique with a retention time of 1.516 minutes. The limit of detection was 0.075μg/ml and the limit of quantification was found 0.25 μg/mL.  The calibration curve plot was found linear over the concentration ranges 5-150 μg/mL, with the regression coefficient (R2) of 0.990. The % assay of the marketed dosage form was found at 97.40 %, which is within the acceptance level. The present method of ulipristal force degradation study was performed as per the guidelines. The results of the force degradation study show the highest 11.39% degradation in an acidic stressed condition, in comparison to alkaline, peroxide, thermal and photolytic stressed conditions. The experiential evidence of all the study results revealed the suitability of the quantification of ulipristal in API and tablet formulation routinely.
UNCERTAINTY ASSESSMENT FOR HYDROCARBON RESERVES VOLUMETRIC CALCULATION
Authors: Тихомирова Елизавета Алексеевна , Мищенко Кирилл Павлович
Published: April 2021

В современных экономических условиях остро необходима тщательная проработка рисков и неопределенностей различной природы на этапах разведки и разработки месторождений углеводородов. Особенно важны неопределенности параметров, используемых при подсчете запасов. К ним относятся пористость, эффективная толщина пласта, нефтенасыщенность, объемный коэффициент. В статье рассмотрены существующие подходы к оценке неопределенности параметров, входящих в формулу объемного подсчета запасов, а также предложен способ количественной оценки неопределенности для пористости, песчанистости и нефтенасыщенности с учетом плотности сетки пробуренных скважин.

In the current economic conditions, there is an urgent need for a thorough study of risks and uncertainties of various nature at the stages of exploration and development of hydrocarbon deposits. Uncertainties of the parameters used in reserves calculation are especially important. These include porosity, effective reservoir thickness, oil saturation, and volumetric ratio. The article discusses the existing approaches to assessing the uncertainty of the parameters included in the formula for the volumetric calculation of reserves, and also proposes a method for quantifying the uncertainty for porosity, net-gross content and oil saturation, taking into account the density of the grid of drilled wells.
FUNCTIONAL DESTRUCTION OF CITIES IN THE CONFLICT REGIONS OF SYRIA
Authors: Яковлева Светлана Ивановна , Альсулейман Мохаммад Исса
Published: April 2021

Цель исследования - дать представление о трансформации социально-экономических функций в наиболее крупных городах региона конфликтного типа на примере городов-центров провинций Сирии. Новизна исследования - в объекте (регионы конфликтного типа) и постановке вопроса о сжатии зон влияния городов с разрушенными функциями, т.е. трансформации пространственных функций городов.

The purpose of the study is to give an idea of the transformation of socio-economic functions in the largest cities of the region of the conflict type using the example of the cities-centers of the provinces of Syria. The novelty of the research lies in the object (regions of the conflict type) and in the formulation of the question of the compression of the zones of influence of cities with destroyed functions, i.e. transformation of the spatial functions of cities.
KONIGSBERG-KALININGRAD IMAGE TRANSFORMATION
Authors: Бродская Юлия Алексеевна , Яковлева Светлана Ивановна
Published: April 2021

Цель исследования - анализ трансформации городского образа на примере Кёнигсберга-Калининграда. Новизна исследования - в применение градостроительной схемы К.Линча (1960) к анализу разновременной пространственной структуры крупного старого немецкого города Кёнигсберга и послевоенного (современного) Калининграда.

The aim of the research is to analyze the transformation of the urban image on the example of Königsberg-Kaliningrad. The novelty of the research lies in the application of the urban planning scheme of K. Linch (1960) to the analysis of the multi-temporal spatial structure of the large old German city of Königsberg and post-war (modern) Kaliningrad.
SCHOOL STUDY OF THE GEOGRAPHY OF HAZARDOUS EVENTS (ON THE EXAMPLE OF A THUNDERSTORM) AND FORMATION OF A SAFE LIFE EXPERIENCE
Authors: Прокофьева Наталья Борисовна , Осипова Екатерина Васильевна
Published: April 2021

Цель исследования - экспериментально-практическая разработка для школьного курса географии 6 кл. по теме «Атмосфера» на примере изучения опасных атмосферных явлений (грозы) с элементами ОБЖ. Грозовые явления в школьной географии не изучаются. Это актуализирует данное исследование и определяет его новизну.

The purpose of the study is experimental and practical development for a 6th grade school geography course on the topic "Atmosphere" on the example of studying dangerous atmospheric phenomena (thunderstorms) with elements of life safety. Thunderstorms are not studied in school geography. This actualizes this research and determines its novelty.Key words: teaching methods of geography, geography of dangerous phenomena, thunderstorm activity.
A cross-sectional analysis of investigator needs for non-communicable disease research at the University of the West Indies, Mona
Authors: Williamson Georgia A , Rodrigo Shelly , Guthrie-Dixon Natalie , Blackman Elizabeth , Beck J Robert , Hambleton Ian , Bailey Althea , Paul Tomlin , Ragin Camille C , Tulloch-Reid Marshall K
Published: April 2021

Objective. To describe the needs of academic staff conducting non-communicable disease (NCD) research at the University of the West Indies, Mona Campus in Jamaica.

Methods. Utilizing a cross-sectional design an online survey was created using the research electronic data capture application (REDCap); it was disseminated via email to 708 academic staff members in the Faculties of Medical Sciences and Science & Technology between September and November 2018. Participants were asked to indicate their level of access to expertise, training and equipment for conducting research. Descriptive analysis was conducted using STATA version 14.

Results. Most respondents were women (74.2%), predominantly scientists (33.1%) or specialist physicians (22.6%). Less than 2/3 of respondents reported publishing research findings in peer reviewed journals, with a quarter not disseminating their research findings in any medium. Resources for field research/data collection, epidemiological methods and principles, and data management/data analysis were generally available. However, there was limited access to training, expertise and equipment in emerging techniques for NCD research such as metabolomics, bioinformatics/analysis of large-scale data sets and health economics. Additional challenges included limited access to financing for research, inadequate workspace and poor administrative support for conducting research.

Conclusions. There is a need for more local research seed funding, stronger administrative support for researchers, and opportunities for training in cutting edge NCD research techniques. Jamaican researchers could benefit from being part of a regional research centre of excellence with critical research skills and equipment that builds research networks and strengthens the NCD research response.
Accounting and Analytical Support of Public Procurement in the Electronics Industry in the Digitalization
Authors: Kogdenko V. G.
Published: April 2021

The article deals with the problems of accounting and analytical support of public procurement in the electronics industry; one of the objectives of the study is to substantiate the criteria for assessing suppliers' reputation; evaluations of persons filing procurement complaints; procurement monitoring indicators. In the process of research, the author used such general scientific principles and methods as abstraction, generalization, as well as statistical methods of data processing. As a result, there has been developed a methodology for assessing the suppliers' reputation including three stages. At the first one — participating companies are assessed according to the criteria of size, industry, ownership, organizational and legal form, data transparency for subsequent calculations. At the second stage — the economic viability of the subjects is assessed in terms of the availability of financial, material and human resources, as well as the effectiveness of companies and the dynamics of their growth. At the third stage — the conscientiousness of the participants is assessed according to the criteria of the authorized capital, credit limit, tax burden, the Spark-Risk lists inclusion. The technique has been tested on data from the register of unscrupulous suppliers supplying products for the electronics industry; the data for analysis has been generated on the basis of 1360 companies. Calculations have shown that the overwhelming majority of unscrupulous suppliers are micro-enterprises that do not belong to the production related industries, repair, and in electronics trade; the significant part of them are registered in Moscow and its region. There is found out some companies which are unscrupulous suppliers of electronic products. They do not have sufficient financial, material and human resources and are characterized by low reputation characteristics. The proposed changes in the legislation in the introduction of prequalification terms require an adequate accounting and analytical support that would help to control the admittance of only participants with high reputational characteristics that can and should be allowed in the public procurement system.
The Development of Chinese Statistical Accounting During the Qin and Han Dynasties
Authors: Amurskaya M. A.
Published: April 2021

The Chinese experience in the development of accounting thought and economic statistics is of a particular interest to Russian scientific thought, since China has been confidently demonstrating economic success for many years. The research was carried out using the methods of sampling, grouping, systematization, comparison and generalization. The historical approach was applied to the analysis of theoretical and practical materials in the Chinese language. The two periods of the development of Chinese statistical thought are distinguished: 1) the period of the Qin dynasty (221-207 BC), starting from which the Chinese state is usually regarded as centralized, and statistical accounting is regarded as national; 2) the period of the Han dynasty (206 BC — 220 AD), during which the active development of statistical accounting continued and a fairly effective system was formed that satisfies all the needs of the state at the central and local level. The practical significance of the work lies in highlighting the methods of centralizing the collection of statistical data and the organization of statistics in China, the regulation of statistical accounting and related accounting. The article presents ideas and practical recommendations of the main thinkers, academicians and scientists (such as Sima Qian, Xu Gan) in the field of statistical accounting in China at that time.
Cyberbullying among teenage K-pop fans
Authors: Andriani Andriani , Anwar Citra Rosalyn , Akram Nuritriani , Alimuddin Nur Aeni
Published: April 2021

This study aims to discuss how teenage K-pop fans need a proper approach to be introduced to the forms of cyberbullying, to describe how to recognize and overcome cyberbullying, and to discuss K-pop as media literacy for K-pop fans. This study was a library research with a qualitative approach. Data were collected through questionnaire and observation. The results of observation indicated that the easy access to the internet and the unlimited use of social media have contributed to the popularity of K-pop in Indonesia. K-pop fans can easily access their idols’ songs, music videos, activities, etc. Social media, which have been widely used thanks to the convenience and affordability of internet access, have posed positive and negative impacts. One of the most alarming negative impacts of social media is cyberbullying. The results of the study showed that: 1) there were different forms of cyberbullying experienced by K-pop fans, and 2) there were different sources of cyberbullying experienced by teenage K-pop fans, including inside, internal, and external sources.
Penegakan Hukum Hak Cipta Terhadap Pembajakan Film Secara Daring
Authors: Suran Ningsih Ayup , Hediyati Maharani Balqis
Published: April 2021

Hak cipta merupakan hak eksklusif pencipta yang timbul secara otomatis berdasarkan prinsip deklaratif setelah suatu ciptaan diwujudkan dalam bentuk nyata tanpa mengurangi pembatasan sesuai dengan peraturan perundang-undangan. Pelanggaran hak cipta bisa memberi dampak buruk bagi penciptanya, sering kali pelanggaran hak cipta membuat pemilik dari hak cipta mengalami kerugian ekonomi. Dalam hal ini, tentunya perlindungan hukum hak cipta harus ditegakkan. Karya sinematografi yaitu film yang seharusnya dilindungi hak penciptanya oleh Undang-Undang Hak Cipta, tetapi dalam kenyataannya banyak yang melakukan pembajakan digital dan illegal downloading dari film aslinya. Kemajuan teknologi sekarang ini membawa dampak yang baik sekaligus dampak yang buruk. Pembajakan digital di era sekarang yang semakin marak. Kurangnya kesadaran masyarakat mengenai penegakan hukum hak cipta merupakan salah satu faktor terjadinya pelanggaran hak cipta seperti download film online. Artikel ini membahas tentang bagaimana dampak buruk download film melalui cara yang tidak legal atau pembajakan digital serta penegakan hak cipta dalam menghadapi masalah illegal downloading. Penelitian ini menggunakan metode hukum normatif dengan Statute Approach.
PHYSIOLOGICAL FUNCTION ENZYMES OF LACTIC ACID BACTERIA
Authors:   Of the Russian state agrarian University – MAA named by K.A. Timiryazev, SIDORENKO O.D. , ZHUKOVA E.V. , PASTUKH O.N.
Published: April 2021

The article provides information about the features of the ecology of lactic acid bacteria of national dairy products and the possibilities of their use for the production of therapeutic and preventive products. The physiological characteristics of lactic acid bacteria (proteolysis, pigmentated, resistance, etc.) can be eff ective in gastroenterological practice