bluuebunny/crossref_metadata_2025 huggingface dataset:
Detecting Cognitive Impairment Status Using Keystroke Patterns and Physical Activity Data among the Older Adults: A Machine Learning Approach
Authors: Hossain Mohammad Nahid , Uddin Mohammad Helal , Thapa K. , Al Zubaer Md Abdullah , Islam Md Shafiqul , Lee Jiyun , Park JongSu , Yang S.-H.
Published: December 2021

Cognitive impairment has a significantly negative impact on global healthcare and the community. Holding a person’s cognition and mental retention among older adults is improbable with aging. Early detection of cognitive impairment will decline the most significant impact of extended disease to permanent mental damage. This paper aims to develop a machine learning model to detect and differentiate cognitive impairment categories like severe, moderate, mild, and normal by analyzing neurophysical and physical data. Keystroke and smartwatch have been used to extract individuals’ neurophysical and physical data, respectively. An advanced ensemble learning algorithm named Gradient Boosting Machine (GBM) is proposed to classify the cognitive severity level (absence, mild, moderate, and severe) based on the Standardised Mini-Mental State Examination (SMMSE) questionnaire scores. The statistical method “Pearson’s correlation” and the wrapper feature selection technique have been used to analyze and select the best features. Then, we have conducted our proposed algorithm GBM on those features. And the result has shown an accuracy of more than 94%. This paper has added a new dimension to the state-of-the-art to predict cognitive impairment by implementing neurophysical data and physical data together.
Application of Extended Lattice Gas Automata Model in Ship Evacuation Simulation
Authors: Han Haoyang , Zhang Jundong , Jiang Ruizheng
Published: December 2021

Lattice gas automaton is a mathematical model that is used to simulate the horizontal uniform evacuation behaviour of a group. However, extended lattice gas automata model is proposed to examine marine evacuation behaviour, which is subject to deck heeling. The application of distance accumulation algorithm and the conversion probability mostly make the extended model, while the approach deals with the most complicated ship evacuation. Moreover, the suggested model is expected to enhance the safety and efficiency of evacuation. The distance accumulation lattice gas automata model considers multiple movement behaviours, flow density, deck heeling, counterflow, and congestion. Movement behaviour will be severely affected in deck heeling process where people may walk normally, walk while bent over, or crawl. To verify the proposed model, 11 test scenarios and several emergency evacuation scenarios are demonstrated. The simulation results explain the validity of another experimental model. The number of people in counterflow, deck heeling, and difference in movement have a direct effect on evacuation, which is as discussed in results. This research article provides a brief study on ship design and crew response behaviour in case of mishap/accident.
UBC Mediated by SEPT6 Inhibited the Progression of Prostate Cancer
Authors: Zhang Ruochen , Yang Yaojing , Huang Haijian , Li Tao , Ye Liefu , Lin Le , Wei Yongbao
Published: December 2021

Background. Prostate cancer is one of the most common malignancies in men. Protein ubiquitination is an important mechanism for regulating protein activity and level in vivo. We aimed to study the mechanism of SEPT6 and UBC action in prostate cancer to identify new targets. Methods. The ubiquitin-protein and the ubiquitin coding gene UBA52, UBA80, UBB, and UBC expressions were detected in clinical tissues and cells. Overexpression and knockdown of UBC were performed in prostate cancer DU145 cells. Cell Counting Kit 8 (CCK-8) assay was performed to detect cell proliferation. Cell cycle at 24 h was detected by flow cytometry. Clonal formation assay was used to measure cell clone number. Immunofluorescence (IF) was performed to detect the colocalization of SEPT6 and UBC in prostate cancer cells. Next, we overexpressed or knocked down SEPT6 expression in DU145 cells. Pearson correlation coefficient was applied to analyze the relationship between SEPT6 and UBC in prostate cancer tissue. oe-SEPT6+oe-UBC coexpressing cells were constructed to detect the upstream and downstream relationship between SEPT6 and UBC on prostate cancer cells. The tumor formation experiment was performed to explore SEPT6/UBC effect on prostate cancer. Results. UBC was upregulated in prostate cancer tissues and cells. Overexpression of UBC promoted cell survival and proliferation. IF revealed the colocalization of SEPT6 and UBC in prostate cancer cells. UBC expression decreased after oe-SEPT6, while increased after sh-SEPT6, indicating that UBC was downstream of SEPT6. Pearson correlation coefficient analysis showed that SEPT6 was negatively correlated with UBC in prostate cancer tissues. SEPT6 as an upstream gene of UBC regulated prostate cancer cell behavior through UBC. The tumor formation experiment showed that SEPT6 could inhibit tumor growth. Conclusion. In general, SEPT6 inhibited UBC expression, thereby reducing the overall ubiquitination level, affecting the expression level of downstream cell proliferation-related genes, and then affecting the progression of prostate cancer.
Bibliometric Analysis of the Scientific Literature on Rheumatoid Arthritis‐Associated Interstitial Lung Disease
Authors: Zhang Yuan , Zhao Tingxiao , Wu Tianjin , Huang Wei , Wu Teng , Shi Yunjuan , Ying Zhenhua
Published: December 2021

Background. In recent years, the number of studies on rheumatoid arthritis‐related interstitial lung disease (RA‐ILD) has been increasing, which has led to many publications on this topic. Our purpose is to identify research trends in RA‐ILD and analyze the most‐cited RA‐ILD‐related high‐quality scientific publications. Methods. All publications on RA‐ILD in the Core Collection database of Web of Science were searched. The publication year, country, institution, total citations, and journal were extracted and analyzed. We used VOSviewer software or an online bibliometric analysis platform for cooccurrence analysis of the keywords, institutions, and countries involved. The 100 most frequently cited RA‐ILD publications were analyzed. Results. In total, 596 publications related to RA‐ILD were obtained. Over time, the frequency of RA‐ILD publications has increased. Globally, the United States provides the most publications on RA‐ILD (n = 195). The institution with the highest publication output was the Mayo Clinic (n = 43). The journal “Annals of the Rheumatic Diseases” published most with 93 articles and received 338 citations. A clinical description was the most common research topic in RA‐ILD‐related publications. Conclusions. In recent years, there has been an increasing number of studies on RA‐ILD, and related publications have increased rapidly. This study is the first bibliometric study of RA‐ILD‐related publications. It can be used as a guide for clinicians and can help researchers choose research directions of interest in this field.
Enhanced Recovery after an Innovative Percutaneous Endoscopic Transforaminal Lumbar Interbody Fusion for the Treatment of Lumbar Spinal Stenosis: A Prospective Observational Study
Authors: Yin Peng , Gao Haifeng , Zhou Lijin , Pang Daming , Hai Yong , Yang Jincai
Published: December 2021

Background. The objective of this study was to investigate the enhanced recovery clinical effects of an innovative percutaneous endoscopic transforaminal lumbar interbody fusion (PE-TLIF) for the treatment of patients with LSS and degenerative instability. Methods. From January 2019 to March 2020, 51 patients with single-segment LSS and degenerative instability were prospectively included in our study (ChiCTR1900020679). The Oswestry Disability Index (ODI), the visual analogue scale (VAS) on lumbar and leg pain (VAS-LBP and VAS-LP), serum creatine kinase (CK), the peak intensity of sulphur hexafluoride microbubble contrast agent (PI), and the maximal cross-sectional area of multifidus muscle (Max-CSA) around the surgical incision were assessed preoperatively, postoperatively, and at regular follow-up. Results. All patients were followed up. The mean postoperative bedridden time was 20.45 ± 2.66 hours. The ODI, VAS-LBP, and VAS-LP were improved significantly after operation compared to these data before operation in all the patients (

P
<
0.05

). The CK at 1 day after operation was higher compared to the data before the operation (

P
<
0.05

), and there was no significant difference on CK at 1 week after operation (

P
>
0.05

). The PI at 1 week after operation was higher compared to this item before operation (

P
<
0.05

), and there was no significant difference on PI at 1 month or 3 months after operation (

P
>
0.05

). The Max-CSA at 1 week after operation was higher compared to this item before the operation (

P
<
0.05

), and there was no significant difference in Max-CSA at 1 month or 3 months after operation compared with before the operation (

P
>
0.05

). Conclusions. Our results and systematic review presented the innovative PE-TLIF technique could obtain satisfactory and effective outcomes for the treatment of patients with LSS and degenerative instability. Our PE-TLIF technique also had the ability to decrease the MF injury and obtain an enhanced recovery.
A Simulation-Based Study for Progressive Estimation of Population Mean through Traditional and Nontraditional Measures in Stratified Random Sampling
Authors: Javed Maria , Irfan Muhammad , Bhatti Sajjad Haider , Onyango Ronald
Published: December 2021

This study suggests a new optimal family of exponential-type estimators for estimating population mean in stratified random sampling. These estimators are based on the traditional and nontraditional measures of auxiliary information. Expressions for the bias, mean square error, and minimum mean square error of the proposed estimators are derived up to first order of approximation. It is observed that proposed estimators perform better than the traditional estimators (unbiased, combined ratio, and combined regression) and other recent estimators. A real dataset is used to highlight the applicability of proposed estimators. In addition, a simulation study is carried out to assess the performance of new family as compared to other estimators.
Subacute Thyroiditis Presenting as Idiopathic Intracranial Hypertension
Authors: Boonyatarp Kanyanatt , Samintharapanya Kanoksri , Vongchaiudomchoke Thanawat , Wachiraphansakul Nuttaya
Published: December 2021

Background. Several case reports have illustrated a rare neurological manifestation, idiopathic intracranial hypertension (IIH), in patients with thyrotoxicosis. However, none were diagnosed with thyroiditis. We report the case of a patient with subacute thyroiditis who presented with severe intractable headache due to IIH. Case Presentation. A 36-year-old woman visited Lampang Hospital in February 2021 complaining of neck pain and progressive severe intractable headache. Her vital signs and neurological examination were normal. Thyroid examination revealed a single 1 cm right thyroid nodule. A computed tomography (CT) scan of her brain illustrated diffuse brain edema. However, CT angiography and venography of the brain did not show abnormalities. The opening pressure of the cerebrospinal fluid was elevated (27 cmH2O). The free triiodothyronine level was 6.19 pg/mL, free thyroxine was 2.32 ng/dL, and thyroid-stimulating hormone was 0.0083 μIU/mL. Anti-Tg was positive at a low titer, but anti-TPO was negative. TRAb was also negative. Methimazole and acetazolamide were prescribed and monitored. The symptoms resolved completely within 2 weeks of onset. Thyroid hormones had returned to normal by 8 weeks. Conclusion. This is the first case report of subacute thyroiditis presenting with IIH.
Effect of Duration of Silicone Oil Tamponade on Retinal Structure after Rhegmatogenous Retinal Detachment Surgery
Authors: Dubroux Chloé , Salleron Julia , Angioi-Duprez Karine , Berrod Jean-Paul , Conart Jean-Baptiste
Published: December 2021

Purpose: The aim of the study was to investigate the effect of tamponade duration on retinal changes induced by silicone oil (SO) in patients who underwent successful rhegmatogenous retinal detachment (RRD) surgery. Methods: Retrospective comparative case series of 68 patients who underwent SO tamponade for RRD. Patients were divided into 2 groups based on timing of SO removal: <6 months (group 1, n = 34) versus ≥6 months (group 2, n = 34). The main outcome measure was the change in central macular, inner, and outer retinal layer thickness (CMT, IRLT, and ORLT) before and after SO removal (SOR). Results: The median tamponade duration was 4 [Clin Ophthalmol. 2016;10:471–6, Zhonghua Yan Ke Za Zhi. 1997 Jan;33(1):39–41] months in group 1 and 8 [Arch Ophthalmol. 1994 Jun;112(6):778–85, Retina. 2004 Dec;24(6):871–7] months in group 2 (p < 0.001). The mean CMT significantly increased from 245.3 ± 22.2 μm and 238.8 ± 41.6 μm under SO to 281.3 ± 60.2 μm and 259.0 ± 43.5 μm after SOR in group 1 (p = 0.009) and in group 2 (p = 0.007), respectively. Automated segmentation measurement revealed a significant increase in mean IRLT (p = 0.014 and p = 0.013) but no change in mean ORLT (p = 0.080 and p = 0.257) in both groups. After adjustment, there was no difference between the 2 groups in terms of mean final CMT, IRLT, and ORLT and mean retinal thickness changes after SOR. There was also no correlation between the tamponade duration and macular microstructural changes or visual recovery. Conclusion: SO tamponade causes a thinning of all retinal layers, mainly affecting the inner retinal layer. However, these changes resolved following SO extraction and were not affected by longer tamponade duration.
Evaluation of Risk Factors and Approach to Screening for Asymptomatic Neonatal Hypoglycemia
Authors: Cummings Christopher T. , Ritter Victor , LeBlanc Sherri , Sutton Ashley G.
Published: December 2021

Introduction: Protocols to identify asymptomatic neonatal hypoglycemia (NH) rely on the presence of established risk factors (late preterm gestation, large or small for gestational age, and infant of a diabetic mother) for inclusion. We analyzed the performance of these risk factors in identifying hypoglycemia in modern practice, and additionally evaluated the optimal duration of screening blood glucose measurements. Methods: We analyzed a retrospective cohort of 830 infants with 1 or more known risk factor(s) for NH admitted to the mother-baby unit of a single tertiary-care center from May 2017 to April 2018. Manual chart review was performed for data extraction and confirmation of risk factor(s). Infants were excluded if glucose measurements were obtained for any reason other than screening for asymptomatic NH. Results: Of the 830 included infants, 31 (3.7%) ultimately received intravenous dextrose (IVD). Most screened infants (n = 510, 61.4%) did not develop hypoglycemia. None of the established risk factors showed strong association with hypoglycemia. Cesarean delivery was associated with hypoglycemia, although not strongly. All infants who received IVD for feeding-refractory hypoglycemia were identified by the first 2 measurements with nearly all (30/31, 97%) identified at the initial measurement. Conclusions: Currently accepted risk factors are limited in their ability to identify infants who subsequently develop hypoglycemia, and as a result, most screened infants do not develop hypoglycemia. The majority of infants in our cohort who did develop hypoglycemia achieved normoglycemia with feeding-based interventions and did not require IVD. Those that received IVD were more likely to develop hypoglycemia early and to a more severe degree. Together, our data suggest further refinement of protocol duration and risk factors utilized for screening as potential areas of screening protocol optimization.
Therapeutic Potential of Sunitinib in Ameliorating Endothelial Dysfunction in Type 2 Diabetic Rats
Authors: Mahdi Ali , Jiao Tong , Tratsiakovich Yahor , Wernly Bernhard , Yang Jiangning , Östenson Claes-Göran , Danser A.H. Jan , Pernow John , Zhou Zhichao
Published: December 2021

Introduction: Sunitinib, a multi-targeted tyrosine kinase receptor inhibitor used to treat renal-cell carcinoma and gastrointestinal stromal tumor, was recently shown to have a beneficial effect on metabolism in type 2 diabetes (T2D). Endothelial dysfunction is a key factor behind macro- and microvascular complications in T2D. The effect of sunitinib on endothelial function in T2D remains, however, unclear. We therefore tested the hypothesis that sunitinib ameliorates endothelial dysfunction in T2D. Methods: Sunitinib (2 mg/kg/day, by gavage) was administered to T2D Goto-Kakizaki (GK) rats for 6 weeks, while water was given to GK and Wistar rats as controls. Hemodynamic, inflammatory, and metabolic parameters as well as endothelial function were measured. Results: Systolic, mean arterial blood pressures, plasma tumor necrosis factor α levels, kidney weight to body weight (BW) ratio, and glucose levels were higher, while BW was lower in GK rats than in Wistar rats. Six-week treatment with sunitinib in GK rats did not affect these parameters but suppressed the increase in glucose levels. Endothelium-dependent relaxations were reduced in both aortas and mesenteric arteries isolated from GK as compared to Wistar rats, which was markedly reversed in both types of arteries from GK rats treated with sunitinib. Conclusions: This study demonstrates that sunitinib has a glucose-lowering effect and ameliorates endothelial dysfunction in both conduit and resistance arteries of GK rats.
Clinical Features of Wheat Allergy Are Significantly Different between Tri a 14 Sensitized Patients and Tri a 19 Sensitized Ones
Authors: Pastorello Elide Anna , Toscano Alessandro , Scibilia Giuseppe , Stafylaraki Chrysi , Rossi Carlo Maria , Borgonovo Linda , Nichelatti Michele , Farioli Laura
Published: December 2021

Introduction: Wheat is the most important cereal for human nutrition but its high consumption is associated to an increasing complaint of wheat-related disorders, many of which are allergic in nature and different in respect to the involved allergens. In this study, we compared the clinical aspects of wheat allergy presented by patients sensitized to Tri a 19 in respect to those presented by patients sensitized to Tri a 14. Methods: With this aim, we selected patients sensitized to 1 or both of the 2 allergens, and among these we identified those who were really wheat allergic and reactive on the basis of a standardized methodology. We evaluated the clinical features such as the kind and severity of symptoms, the coexistence of triggering factors such as physical exercise and NSAIDs and alcohol consumption, and the association with other allergens and with various immunologic parameters. Wheat allergy in Tri a 19 sensitized patients was confirmed through a questionnaire while the patients sensitized to Tri a 14 underwent wheat challenge with 100 g of pasta followed by exercise on a treadmill. Results: Seventy-nine patients sensitized to Tri a 14 and 40 patients sensitized to Tri a 19 were recruited. The 2 sensitizations were independent with a significant inverse relation (p < 0.00001). The Tri a 19 sensitized patients presented, in respect to the Tri a 14 sensitized ones, an older age (p = 0.0017), a higher risk to be wheat allergic (p < 0.0001), a higher severity of the reactions (p < 0.00001) and a higher association with some cofactors, namely alcohol (p < 0.0005) and physical exercise (p = 0.003). On the contrary, Tri a 14 sensitization was associated with atopy (p < 0.0001), with a higher probability of patients being asymptomatic (p < 0.0001) and being sensitized to other foods, in particular to nuts and cereals (p < 0.00001). Conclusions: Sensitization to Tri a 19 or Tri a 14 determines different clinical pictures. In particular, sensitization to Tri a 19 implies a higher probability of severe reactions, even dependent on daily triggers, while that to Tri a 14 implies a higher cross-reactivity with other foods but it’s more frequently asymptomatic, making a food challenge necessary to prevent useless food avoidance.
Emerging Role of Exosomal-Derived Long Noncoding RNAs in Human PDAC
Authors: Long Di , Tian Xiao Dong , Yang Yin-Mo
Published: December 2021

Background: The incidence and mortality of pancreatic ductal adenocarcinoma (PDAC) are increasing recently. Most patients with PDAC are diagnosed at advanced stage because of the high invasiveness of cancer cells and the lack of typical early symptoms. Therefore, early diagnosis of PDAC is very important to improve the prognosis. Exosomes play crucial role in intercellular communication and deliver the contents to recipient cells to regulate their biological behaviors. Recent evidence suggests emerging role of exosomes in the carcinogenesis of a variety of cancers including PDAC. Long noncoding RNAs (LncRNAs) have been reported to be involved in the development of PDAC. It has been proved that LncRNAs have the potential to be biomarkers and therapeutic targets for PDAC. Moreover, increasing number of studies focus on the role of exosomal LncRNAs in PDAC. Summary: In this review, we summarize the current status on our understanding of the role of exosomal-derived LncRNAs in the progression and metastasis of PDAC. Key Messages: We focus on challenges in the potential of exosomal-derived LncRNAs as novel diagnostic and prognostic markers and therapeutic targets of PDAC. In addition, we provide an overview about the demonstrated important role of exosomal LncRNAs in the progression of PDAC.
Vamos investigar? atividades didáticas para a área de ciências da natureza e suas tecnologias
Authors:   Universidade de São Paulo. Escola Superior de Agricultura ",   Luiz de Queiroz"
Published: December 2021

Esse material contempla sugestões de atividades didáticas para o Ensino Médio, com ênfase no componente curricular Biologia, e foi organizado durante o desenvolvimento de um projeto de extensão universitária denominado: “Material Didático: divulgando práticas e recursos pedagógicos para o ensino de Ciências da Natureza e suas Tecnologias”, realizado com o objetivo de difundir conhecimentos produzidos em pesquisas acadêmicas, validados em projetos de ensino e de extensão universitária, envolvendo estudantes dos cursos de Licenciatura em Ciências Biológicas e Licenciatura em Ciências Agrárias da ESALQ/USP, professores e estudantes da Educação Básica. O convite do título: “Vamos investigar?” é dirigido primeiramente para professores que, a partir da proposta apresentada, deverão planejar a atividade alinhada ao contexto da turma com a qual trabalham, de modo a convidar estudantes a investigarem o conteúdo a ser abordado. Para tanto, foram descritas quatro metodologias de ensino: atividades práticas, debates, aulas de campo e jogos. A maioria das atividades são classificadas como atividades práticas pois, atendendo demandas da Escola parceira, foram desenvolvidas na disciplina Práticas em Ciências, cujo foco foram aulas práticas para estudantes do Ensino Médio.
Use of Pulmonary Arterial Hypertension Therapies in Patients with a Fontan Circulation: Current Practice Across the United Kingdom
Authors: Constantine Andrew , Dimopoulos Konstantinos , Jenkins Petra , Tulloh Robert M. R. , Condliffe Robin , Jansen Katrijn , Chung Natali A. Y. , Oliver James , Parry Helen , Fitzsimmons Samantha , Walker Niki , Wort Stephen John , Papaioannou Vasilios , von Klemperer Kate , Clift Paul , Clift Paul , Condliffe Robin , Dimopoulos Konstantinos , Jansen Katrijn , Moledina Shahin , Constantine Andrew
Published: December 2021

Background

The Fontan circulation is a successful operative strategy for abolishing cyanosis and chronic volume overload in patients with congenital heart disease with single ventricle physiology. “Fontan failure” is a major cause of poor quality of life and mortality in these patients. We assessed the number and clinical characteristics of adult patients with Fontan physiology receiving pulmonary arterial hypertension (PAH) therapies across specialist centers in the United Kingdom.

Methods and Results

We identified all adult patients with a Fontan‐type circulation under active follow‐up in 10 specialist congenital heart disease centers in England and Scotland between 2009 and 2019. Patients taking PAH therapies were matched to untreated patients. A survey of experts was also performed. Of 1538 patients with Fontan followed in specialist centers, only 76 (4.9%) received PAH therapies during follow‐up. The vast majority (90.8%) were treated with a phosphodiesterase‐5 inhibitor. In 33% of patients, PAH therapies were started after surgery or during hospital admission. In the matched cohort, treated patients were more likely to be significantly limited, have ascites, have a history of protein‐losing enteropathy, or receive loop diuretics (
P
<0.0001 for all), also reflecting survey responses indicating that failing Fontan is an important treatment target. After a median of 12 months (11–15 months), functional class was more likely to improve in the treated group (
P
=0.01), with no other changes in clinical parameters or safety issues.

Conclusions

PAH therapies are used in adult patients with Fontan circulation followed in specialist centers, targeting individuals with advanced disease or complications. Follow‐up suggests stabilization of the clinical status after 12 months of therapy.
Additive Effects of Genetic Interleukin‐6 Signaling Downregulation and Low‐Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis
Authors: Georgakis Marios K. , Malik Rainer , Burgess Stephen , Dichgans Martin
Published: December 2021

Background

Although trials suggest that anti‐inflammatory approaches targeting interleukin (IL)‐6 signaling can reduce cardiovascular risk, it remains unknown whether targeting IL‐6 signaling could reduce risk additively to low‐density lipoprotein cholesterol (LDL‐C) lowering. Here, we assess interactions in associations of genetic downregulation of IL‐6 signaling and LDL‐C lowering with lifetime cardiovascular disease risk.

Methods and Results

Genetic scores for IL‐6 signaling downregulation and LDL‐C lowering were used to divide 408 225 White British individuals in UK Biobank into groups of lifelong exposure to downregulated IL‐6 signaling, lower LDL‐C, or both. Associations with risk of cardiovascular disease (coronary artery disease, ischemic stroke, peripheral artery disease, aortic aneurysm, vascular death) were explored in factorial Mendelian randomization. Compared with individuals with genetic IL‐6 and LDL‐C scores above the median, individuals with LDL‐C scores lower than the median but IL‐6 scores above the median had an odds ratio (OR) of 0.96 (95% CI, 0.93–0.98) for cardiovascular disease. A similar OR (0.96; 95% CI, 0.93–0.98) was estimated for individuals with genetic IL‐6 scores below the median but LDL‐C scores above the median. Individuals with both genetic scores lower than the median were at lower odds of cardiovascular disease (OR, 0.92; 95% CI, 0.90–0.95). There was no interaction between the 2 scores (relative excess risk attributed to interaction index, 0; synergy index, 1;
P
for multiplicative interaction=0.51). Genetic IL‐6 score below the median was associated with lower cardiovascular disease risk across measured LDL‐C strata (<100 or ≥100 mg/dL).

Conclusions

Genetically downregulated IL‐6 signaling and genetically lowered LDL‐C are associated with additively lower lifetime risk of cardiovascular disease. Future trials should explore combined IL‐6 inhibition and LDL‐C lowering treatments for cardiovascular prevention.
Poor correlation between alcohol concentration in oral fluid and breath in subjects consuming beverages immediately before testing
Authors: Bretteville-Jensen Anne Line , Furuhaugen Håvard , Gjerde Hallvard
Published: December 2021

In previous research projects and clinical settings, alcohol analysis in oral fluid (saliva) has been used as an alternative to breath or blood alcohol testing. In this study we examined whether it is possible to obtain clinically relevant data regarding alcohol consumption in individuals who recently consumed alcohol by analysing oral fluid samples when the recommended rinsing of the mouth is impossible before sample collection.
We conducted a study of 89 nightclub patrons in Norway. Before collecting oral fluid samples and performing breath alcohol testing, participants were required to drink a glass of water to remove residual alcohol from the mouth. Oral fluid samples were collected with the Quantisal oral fluid collection device and analysed using an enzymatic method for alcohol. The alcohol concentration in the neat (undiluted) oral fluid was then calculated. Breath alcohol testing was performed using Lion Alcolmeter 500 instruments.
No false-negative or false-positive results for alcohol were detected in the oral fluid when compared with those in the breath. The Intraclass Correlation Coefficient of 0.40 indicated a poor correlation between alcohol concentrations in the two sample types.
The procedure for collecting oral fluid was suitable for the qualitative determination of alcohol intake but not for quantitative assessment. We recommend that oral fluid samples should not be used for estimating blood or breath alcohol concentrations in people who have recently consumed alcohol or non-alcoholic beverages, as recommended in the instructions for use.
Chung-ying Cheng’s Dialogue with Confucianism and Kant: A Gadamerian Critique
Authors: Palmquist Stephen R.
Published: December 2021

Gadamer’s hermeneutics offers several strategies for critiquing Chung-ying Cheng’s synthesis of Confucianism and Kant. Interpreting Kant’s Groundwork, Cheng argues that the distinction between perfect and imperfect duties is too rigid: if the “life principle” is the ultimate root of Kant’s four types of duty, then human inclinations are good; Kant’s perfect duties turn out to be imperfect in some situations, while his imperfect duties such as benevolence (or ren, in Confucian philosophy) turn out sometimes to be perfect. Although Cheng’s synthesis does not satisfy the Groundwork’s universal aim, it does show how to apply Kant’s insights to empirical moral situations.
Final Vowel Loss in Lower Kasai Bantu (drc) as a Contact-Induced Change
Authors: Pacchiarotti Sara , Bostoen Koen
Published: December 2021

In this article, we present a qualitative and quantitative comparative account of Final Vowel Loss (fvl) in the Bantu languages of the Lower Kasai region of the Democratic Republic of the Congo. We argue that this diachronic sound shift rose relatively late in Bantu language history as a contact-induced change and affected adjacent West-Coastal and Central-Western Bantu languages belonging to different phylogenetic clusters. We account for its emergence and spread by resorting to two successive processes of language contact: (1) substrate influence from extinct hunter-gatherer languages in the center of innovation consisting of Bantu B80 languages, and (2) dialectal diffusion towards certain peripheral Bantu B70, C80, H40 and L10 languages.
Clitobius grimmi sp. n. from Egypt with notes on C. oblongiusculus (Fairmaire, 1875) (Coleoptera: Tenebrionidae: Blaptinae)
Authors: LILLIG MARTIN
Published: December 2021

Ten valid species of the genus Clitobius Mulsant & Rey, 1859 have been published so far from the Palaearctic, Afrotropical and Oriental Regions. With C. grimmi sp. n. from Egypt an eleventh species is here described and illustrated. Specimens representing the newly proposed species were identified as C. oblongiusculus (Fairmaire, 1875) in many of the surveyed entomological collections. This could potentially be explained by the superficial convergence of C. grimmi sp. n. with the description of Halomenus lineicollis Fairmaire, 1879, which is now considered a junior synonym of C. oblongiusculus. Morphological distinctiveness of all of the above mentioned taxa is hereby discussed. The lectotype for Halonomus lineicollis Fairmaire, 1879 is designated in order to fix the nomenclatural status of that taxon. The determination key of Purchart & Kamiński (2017) to the Clitobius species is updated with the following taxa: Clitobius subplumbeus (Fairmaire, 1892) and C. grimmi sp. n.
Weather Forecast Semiotics: Public Interpretation of Common Weather Icons
Authors: Reed Jacob R. , Jasko Susan A. , Senkbeil Jason C.
Published: December 2021

Weather icons are some of the most frequently used visual tools that meteorologists employ to communicate weather information. Previous research has shown a tendency for the public to make inferences about weather forecast information on the basis of the icon shown. For example, people may infer a higher likelihood of precipitation, assume a higher intensity of precipitation, or determine the duration of expected precipitation if the weather icon appears to show heavy rain. It is unknown to what extent these inferences align with what the meteorologist who chose the icon intended to convey. However, previous studies have used simulated weather icons rather than ones currently in use. The goal of our study was to explore how members of the public interpret actual weather icons they see on television or in mobile applications. An online survey distributed by broadcast meteorologists through social media was used to collect 6253 responses between August and September of 2020. Eleven weather icons currently used by broadcast meteorologists were included in the study. We also tested eight common weather phrases and asked people whether they thought the icons were good illustrators of those phrases. In addition, people were asked to assign a probability of precipitation to the icons. The findings of our study offer new and unique insights that will improve the communication of weather information by giving meteorologists information about how their audiences interpret weather icons.

Significance Statement

Millions of people are shown weather icons during daily weather broadcasts. This study used two approaches to determine whether these icons are effective elements of weather messaging. For the first approach, we showed people an icon alongside a common weather phrase and had them tell us whether the icon was a good illustrator of the weather phrase. The second approach involved showing people an icon and having them assign a probability of precipitation to it. Across eight weather phrases, none of the icons were thought to be good illustrators, but bad illustrators were clear. These results can be used to improve how icons are used as tools to communicate weather forecasts.
Diagnosis and Management of Suspected Pediatric Autoimmune Encephalitis: A Comprehensive, Multidisciplinary Approach and Review of Literature
Authors: Wright Melissa A. , Trandafir Cristina C. , Nelson Gary R. , Hersh Aimee O. , Inman C. J. , Zielinski Brandon A.
Published: December 2021

Autoimmune encephalitis is an increasingly recognized entity in children. When treated promptly, favorable outcomes are seen in a majority of pediatric patients. However, recognition of autoimmune encephalitis in young patients is challenging. Once autoimmune encephalitis is suspected, additional difficulties exist regarding timing of treatment initiation and duration of treatment, as evidence to guide management of these patients is emerging. Here, we review available literature regarding pediatric autoimmune encephalitis and present our institution's comprehensive approach to the evaluation and management of the disease. These guidelines were developed through an iterative process involving both pediatric neurologists and rheumatologists.
Cultural Capital and Volunteering: A Multilevel Study From China
Authors: Liu Zhiming , Jia Haiwei
Published: December 2021

In this article, we extend Wilson and Musick’s concept of cultural capital, which was defined as the culture of benevolence, to a multilevel concept and build a multilevel cultural capital theory about individual (nonmandatory) volunteering based on religious beliefs, political values, belief in social justice, and belief in social trust in the context of volunteering in China. Data from the 2012 Chinese General Social Survey, China’s national and comprehensive large-scale social survey project, are used to empirically investigate the influences of individual-level cultural capital (values of benevolence) and contextual-level cultural capital (cultural climate of benevolence) on individual volunteering. In terms of individual-level cultural capital, membership in the Chinese Communist Party (China’s ruling party), belief in social justice, and belief in social trust have significant positive relationships with individual volunteering. In terms of contextual-level cultural capital, the religious climate and justice climate in a province have significant positive effects on individual volunteering.
Surface morphology and microstructural analysis of al 8081-mg/zr/tio2 nano metal matrix composite – A base for performance evaluation of polycrystalline diamond and poly cubic boron nitride tools
Authors: Prasad Balla S , KarakaVVNR Chandra M , Annavarapu Venkata S
Published: December 2021

The investigation of surface roughness in machined materials/products has proven to be a difficult undertaking. The surface quality is determined not only by the parameters but also by the cutting conditions. Surprisingly, a study indicated that when analysing the quality of machining processes currently being done, surface morphology has a significant impact on tool performance. PCD (Polycrystalline diamond) and PCBN (Poly cubic boron nitride) cutting tools produce a better surface finish, which is explored in the machining of Al-Mg/Zr/TiO2 (15%), nano metal matrix composites (NMMC). The study primarily focuses on determining the best parameters for end milling NMMCs in tests for long-term production sustainability. Using scanning electron microscopy, microstructural study of the machined surface will aid in finding the parameters responsible for the cause of surface integrity. The work focusses on analysing tool performance by monitoring the machining process in real time using signal characteristics, forecasting vibrations (displacement) and machine outputs using surface topography and chip analysis. The tool failure was acquired by establishing a correlation between displacement (vibrations) and post machining outcome of experimental study, as a result, the evolution of displacement in the PCBN tool is 24.7 μm, which is better compared to 34.3 μm in the PCD tool at 3000 r/min. PCBN outperformed PCD with a 1.82 μm surface roughness, resulting in longer tool life. Thus, this economical reliable empirical method the problem of finding difficulty identifying the causing of tool wear and failure by correlating sensor signals features with experimental results.
Epidemiology of disease-activity related ophthalmological manifestations in Systemic Lupus Erythematosus: A systematic review
Authors: Jawahar Nitish , Walker Jessica K , Murray Philip I , Gordon Caroline , Reynolds John A
Published: December 2021

Objective

Ophthalmic complications in Systemic Lupus Erythematosus (SLE) are broad and can occur in up to a third of patients. The British Isles Lupus Assessment Group (BILAG) 2004 Index identifies 13 ocular manifestations of active SLE, as opposed to those related to previous disease activity and/or the consequences of therapy. We conducted a systematic review of published literature to determine the frequency of ophthalmic manifestations of active SLE.

Methods

A systematic literature search of Ovid MEDLINE and EMBASE from their respective inceptions to July 2020 was conducted to identify cohort, case–control and cross-sectional studies.

Results

22 studies meeting eligibility criteria were included. Most studies featured small sample sizes and were judged to have a high risk of methodological bias. The number and quality of studies did not allow us to confidently estimate the incidence of the conditions. No studies reported epidemiological data for orbital inflammation/myositis/proptosis. The prevalence of each of the other ocular manifestations, with the exception of retinal vaso-occlusive disease, was consistently less than 5%. Retinal vasculitis, uveitis and isolated cotton wool spots tended to be associated with more active SLE disease.

Conclusion

The prevalence of eye disease due to SLE activity is uncommon, but clinicians should be aware that some conditions tend to be associated with more active systemic disease. Further studies to determine the incidence and risk factors for these ophthalmic manifestations are needed.
Judicial Approaches to the Criminalisation of Marital Rape
Authors: Singh Vijay P
Published: December 2021

In India, as in different traditional cultures, women have been and still are treated in a number of inhumane ways. They are controlled, prone to assault and abuse and risk rape not only outside but within their own homes. Moreover, marital rape is not considered a crime in India. The article attempts to analyse Indian rape laws and to show that exemption for marital rape does not align with the fundamental principles of justice and equality, which is the basic feature of the Indian Constitution. The article argues that the exemption clause should be repealed, and marital rape be criminalised. The article further discusses the approach of the Indian judiciary towards the issue of criminalisation of marital rape.
Playing YouTube: How the Nancy YouTuber doll and app position children as aspiring YouTube influencers
Authors: Ruiz-Gomez Alexandra , Leaver Tama , Abidin Crystal
Published: December 2021

This article analyzes Nancy YouTuber, a popular doll and companion app that is part of a growing trend of children's toys modeled on YouTube influencers. Nancy YouTuber's app is one of the first to provide a fictitious YouTube channel, introducing children to YouTube's affordances. We investigate how the doll and app socialize YouTuber practices, and to what extent the combination of both deepens the commodification of childhood. We use the walkthrough method to analyze the app, and a semiotic approach to study the doll, its accessories and surrounding materials to map the manufacturer's intended use through these discourses. Our research uncovers how children are encouraged to recreate product reviews and internalize commercial digital identity performances. We use Spain, where the doll originates, to contextualize these findings. The article considers how influencer-aspirant toys position children as promotional intermediaries and normalize children's YouTuber aspirations.
Cross-infection and infection control in dental clinics in Nablus and Tulkarm districts
Authors: Menawi Wafaa , Sabbah Areej , Kharraz Lubna
Published: December 2021

Background

Infection control had many developments in the COVID 19 (Coronavirus Disease 2019) pandemic, despite this, there were many complications in different health care facilities as well as dentists’ clinics due to the lack of infection control knowledge and compliance failure. This study aimed to assess the level of knowledge and compliance with the infection control measures in the dental clinics in the Nablus and Tulkarm districts.

Results

The results showed that the total positive response regard all infection control domains were (70.0 %). Whereas the participants gave the highest positive response for personnel protective equipment i.e. gloving was (96.10 %). They gave the instruments related to controls the lowest responses, i.e. instruments sterilization was (59.40 %). The analyzed data showed significant statistical differences in the compliance with infection control measures between Nablus and Tulkarm districts “p < 0.05” in the interest of dentists from Tulkarm.

Conclusions

In conclusion, the findings of this study showed that there is moderate compliance to infection control protocol in Nablus and Tulkarm dental clinics. Thus, there is a need to strengthen adherence to infection control measures.

Method

A universal sampling was used to assess the infection control program at the dental clinics in Nablus and Tulkarm Districts. The study sample involved 265 dentists. Data was collected using a questionnaire which has been sent via email between July and August 2020. Descriptive statistics, Chi-square test, One-way ANOVA and Post-Hock tests have been used. Statistical significance was set at ″P <0.05″. Cronbach’s alpha has been conducted to ensure the reliability and validity of the questionnaire.
Optimal outcome factors in maternity and newborn care for inpatient (hospital maternity ward-HMW) and outpatient deliveries (outhospital maternity clinics -OMC)
Authors: Lukač Azra , Šulović Nenad , Ilić Aleksandra , Mijović Milica , Tasić Dijana , Smiljić Sonja
Published: December 2021

Background and objectives

The aim of the study was to use the United States Optimality Index (OI-US) to assess the feasibility of its application in making decisions for more optimal methods of delivery and for more optimal postpartum and neonatal outcomes. Numerous worldwide associations support the option of women giving birth at maternity outpatient clinics and also at home. What ought to be met is the assessments of requirements and what could be characterized as the birth potential constitute the basis for making the right decision regarding childbirth.

Materials and methods

The study is based on a prospective follow-up of pregnant women and new mothers (100 participants) who were monitored and gave birth at the hospital maternity ward (HMW) and pregnant women and new mothers (100 participants) who were monitored and gave birth at the outhospital maternity clinics (OMC). Selected patients were classified according to the criteria of low and medium-risk and each of the parameters of the OI and the total OI were compared.

Results

The results of this study confirm the benefits of intrapartum and neonatal outcome, when delivery was carried out in an outpatient setting. The median OI of intrapartum components was significantly higher in the outpatient setting compared to the hospital maternity ward (97 range from 24 to 100 vs 91 range from 3 to 100). The median OI of neonatal components was significantly higher in the outpatient compared to the inpatient delivery. (99 range from 97 to 100 vs 96 range from 74 to 100). Certain components from the intrapartum and neonatal period highly contribute to the significantly better total OI in the outpatient conditions in relation to hospital conditions.

Conclusion

Outpatient care and delivery provide multiple benefits for both the mother and the newborn.