bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence and Prevalence of Morbidity and Mortality From Sensitive Conditions to Primary Health Care in Adult Men: A Systematic Review and Meta-analysis Protocol
Authors: Paula Cácia Régia de , Borges Cristiane José , Lima Flavio Henrique Alves de , Porto Celmo Celeno , Matos Marcos André , Sousa Ana Luiza Lima , Barbosa Maria Alves
Published: May 2020

Background: Scientific studies on human health are not remote and show that mortality in this population is increasing. Although male morbidity and mortality rates have a considerable weight in national and international epidemiological profiles, the presence of men in primary health care services is lower than that of women. Many injuries could be avoided if men regularly carried out the first preventive measures. Sensitive Conditions to Primary Care are consolidated as an important marker of access to health services and the resolution capacity of Primary Care. In this systematic review, the objective is to identify what is known about the prevalence and / or incidence of Sensitive Conditions to Primary Care in adult men.Methods: We will identify the studies through systematic research in PUBMED-MEDLINE, SCOPUS, Web of Science, Embase, Cochrane, BDTD and OpenGrey. The quality assessment of retrieved articles will be carried out using the critical assessment tools of the Joanna Briggs Institute (JBI). The quantitative synthesis of the data will be carried out if the studies are homogeneous and provide adequate result data for meta-analysis. Otherwise, the data will be synthesized, using the narrative synthesis approach.Discussion: This review will explore theprevalenceand / orincidenceofSensitiveConditionstoprimarycare (prevalenceofhospitalizations; incidenceofhospitalizationsand deaths from ACSC) in adultmenandwillact as a usefulsource for researchers, policymakersand stakeholders whendevelopingandimplementinginterventions for thatgroup. Systematic review registration: This systematic review protocol was submitted to International Prospective Register of Systematic Reviews (PROSPERO). Submission number: ID 169447. This protocol was prepared using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols checklist (PRISMA-P).
High Resolution Late-holocene Terrestrial Biomarkers Records in Southern Continental Shelf Area of the Korean Peninsula: Climate and Marine Environmental Implications During the Last 5 Kyr
Authors: Hyun Sangmin , Kang Nayeon , Cho Jin Hyung
Published: May 2020

High-resolution records for carbon isotopes of organic matter and n-alkane compounds were investigated in two gravity cores (SJP15-2 and SJP15-4) taken from the southern continental shelf of the Korean peninsula to evaluate the variation in influxes of terrestrial organic compounds and their linkage to paleoclimate and marine environmental changes since the last 5 kyr. The total organic carbon contents were < 1%, and the carbon isotope(d13Corg) ratio ranged from approximately −21‰ to -22‰ and, they did not highly fluctuate throughout the two cores. However, the vertical distributions of total terrestrial biomarkers, long-chain n-alkanes (nC25-35), and individual n-alkane compounds exhibited distinctive fluctuations. There are three switching points that discriminate patterns of excursion and distribution at ca. 4.5 ka, 3.0 ka, and 1.8 ka. Several n-alkane combined indices such as average chain length (ACL), carbon preference index (CPI), and paleovegetation index (Paq), were coincident with these switching points, implying that the supply of terrestrial biomarkers was strongly associated with environmental changes at the source area. In particular, the ratios of nC31/nC27 and nC31/nC29 show coincident excursion pattern with lower ratio between 3.0 ka and 1.8 ka, implying that this short-term event-like record (STER) was associated with wetter climate conditions, and thus paleovegetation and paleoclimate variation. Comparison with previous data of the detrital quartz from the East China Sea and aeolian dust in the Cheju (Jeju) Island, South Korea, and Dongge cave oxygen isotope records indicates strong synchronicity with those switching points, suggesting that paleoclimate system of the East Asian region may have influenced the sediment records of study area since the last 5 kyr. Therefore, our high-resolution n-alkane data are very useful for reconstructing past climatic records, and East Asian monsoon and regional records could be associated with the paleoclimate variations of the study area.
Bioinformatics and Expression Analysis of Histone Modification Genes in Grapevine Predict Their Involvement in Seed Development and Hormonal Signaling
Authors: Wang Li , Ahmad Bilal , Liang Chen , Shi Xiaoxin , Sun Ruyi , Zhang Songlin , Du Guoqiang
Published: May 2020

Background
Histone modification genes (HMs) play potential roles in plant growth and development via influencing gene expression and chromatin structure. However, limited information is available about HMs genes in grapes (Vitis vinifera L.).
Results
Here, we described detailed genome-wide identification of HMs gene families in grapevine. We identified 117 HMs genes in grapevine and classified these genes into 11 subfamilies based on conserved domains and phylogenetic relationships with Arabidopsis. We described the genes in terms of their chromosomal locations and exon-intron distribution. Further, we investigated the evolutionary history, gene ontology (GO) analysis, and syntenic relationships between grapes and Arabidopsis. According to results 21% HMs genes are the result of duplication (tandem and segmental) events and all the duplicated genes have negative mode of selection. GO analysis predicted the presence of HMs proteins in cytoplasm, nucleus, and intracellular organelles. According to seed development expression profiling, many HMs grapevine genes were differentially expressed in seeded and seedless cultivars, suggesting their roles in seed development. Moreover, we checked the response of HMs genes against powdery mildew infection at different time points. Results have suggested the involvement of some genes in disease resistance regulation mechanism. Furthermore, the expression profiles of HMs genes were analyzed in response to different plant hormones (Abscisic acid, Jasmonic acid, Salicylic acid, and Ethylene) at different time points. All of the genes showed differential expression against one or more hormones.
Conclusion
VvHMs genes might have potential roles in grapevine including seed development, disease resistance, and hormonal signaling pathways. Our study provides first detailed genome-wide identification and expression profiling of HMs genes in grapevine.
Infection Control of Spatial Disseminated Multi-Antibiotics Resistant And Phylo-Diverse Staphylococcus Aureus Pathotypes
Authors: AKINDUTI PAUL , Osiyemi Joshua , Banjo Temitope , Ejilude Oluwaseun , Ashker Maged , Adewale Adeyemi Gideon , Obafemi Yemisi Dorcas , Isibor Patrick , Oladotun Abiola
Published: May 2020

Focal dissemination of multi-antibiotic resistant (MAR) Staphylococci pathotypes regulated by agr functionalities was investigated and evaluated for infection control. Non-repetitive Staphylococcus aureus strains from soft and skin infections disseminated in several communities were recovered and biotyped, assayed for biofilm and profiled for antibiotic resistance. Strains were further genotyped for spa types, virulence and resistant genes; and mapped for geospatial distribution. Clonal diversity and functional accessory gene regulators (agr) were also evaluated. Staphylococcal infection was not significant with age group (p>0.05), but high rate of MSSA (53.0%) and MRSA (1.5%) was observed. Median resistance rates were significantly differ (p=0.001) but highest 75 th percentile and media resistance rates were observed in wound infection. Resistance rate of 78.8% at MIC 50 32µg/ml and MIC 90 128µg/ml to amoxicillin-clavulanate, and more than 40% resistance to ceftazidime, ciprofloxacin, gentamycin, ofloxacin, sulfamethoxazole and tetracycline with MIC 90 and MIC 50 at 32 µg/ml were observed. More than 0.83 multi-antibiotic resistance index (MARI) were observed among the strains that clustered into separate phylo-group expressing high beta- lactamase and strong biofilm production. Heterogeneous spa types t442 (wound and pus), t657 (wound), t091 (ear) and t657 (ear and wound) revealed high phylo- diversity. Only 4.6% pvl + MSSA-CC1 agr I, pvl+ MSSA-CC5 (13.6%) and pvl+ MRSA-CC7 agr II (4.6%), expressed enterotoxin; sea, sec, sed, sej, Leukocidins ( LukF-PV, lukD, lukE ), proteases (aur, slpA sspB, sspE ) and resistance genes (fosB, msr (A), bla mph(C),aphA3, sat, fosB, sdrM, Q7A4X2) . Phylogenetic related spa types of livestock origin, specifically bovine milk clustered with detected strains that were prevalent in urban communities with focal dissemination to other nearest suburbs. Clonal dissemination resistant pvl+MAR MSSA-CC1 and MRSA- CC5 encoding agr were predominant in several peri-urban communities. This require adequate geno-surveillance, population-target antimicrobial stewardship, extensive community health care intervention policy and well-structured infection control programs to prevent further focal dissemination.
Non-Interactive Amblyopia Treatment Modalities in Children: A Systematic Review and Meta-Analysis
Authors: Hussen Mohammed Seid , Adimassu Nebiyat Feleke , Belete Gizachew Tilahun , Atnafu Asamamaw
Published: May 2020

Background: This review aimed to identify the most effective and safest amblyopia interventions in an integrative manner.Methods: Eligible studies were identified from Cochrane library (CENTRAL), Pubmed central, Google Scholar, ScienceDirect and Scopus database up to 09/2018. Data pooling was performed for trials with a little heterogeneity (P>0.05, I2 <50%) using the fixed-effect models. The mean difference (MD) and risk ratio (RR) at 95% confidence interval (CI) for visual acuity improvement, success of the treatment, reverse amblyopia and adherence rate were pooled.Results: Eight trials consisting of 1253 participants were included. Regardless of child’s age, cause and severity of amblyopia, six hours patching and full-time patching were equally effective (Pooled MD, 0.00; 95% CI, -0.54 to 0.55). Likewise, studies independently reported that two hours and six hours patching were equally effective for moderate amblyopia. The therapeutic outcome of patching was statistically comparable to atropine (pooled MD, 0.25 lines; 95% CI, 0.01 to 0.48). The weighted adherence rates for atropine was encouraging as compared to patching (pooled RR, 0.9; 95% CI, 0.84 to 0.96). However, significant reverse amblyopia and poor adherence was recognized in full-time patching and atropine. The risk of developing reverse amblyopia was lower by 19% for patching groups as compared to atropine (pooled RR, 0.19; 95% CI: 0.06 to 0.57). Conclusion: Overall, considering six hours patching or atropine penalization as a first line treatment is a fair decision from effectiveness perspective but it should be under proactive monitoring to optimize the noted adherence and adverse effects issues.
Thermochromic Detection of Ultrasound-Induced Nanoparticle Heating in Tissue-Mimicking Solid Gel
Authors: Lin Huiting , Chen Nelson Gee-Con , Huang Chih-Mao
Published: May 2020

Background

Microbubble has been extensively used for ultrasound imaging and many other applications such as ultrasound cleaning. Few studies have been reported on ultrasound interactions with small nanoparticles (< 250 nm). Due to the broad use of nanoparticles in many different fields, it is critically important to clarify whether nanoparticles can have strong interaction with ultrasound. In addition, Nanoparticle assisted ultrasound therapy has recently been found to have selective killing of cancer cells compared to normal cells. Nevertheless, the mechanism is not known. The major possible mechanisms for killing cells are cavitation and heating. In this work, a simple thermochromic method is developed to clearly indicate that the interaction of nanoparticle with ultrasound can lead to temperature rise that can lead to selective killing of cancer cells.
Results

Direct three-dimensional detection of ultrasonically induced heating in a nanoparticle bearing tissue-mimicking gel would provide a means to estimate their effectiveness as thermally-based sonosensitizers. Such a gel was produced through the addition of an irreversible thermochromic liquid to a well-known agarose gel during fabrication. Polystyrene nanoparticles were embedded within gels during production. The placement of gels within a temperature-controlled bath set to a temperature below the transition temperature allows for the visual detection of slight temperature increases. The modified gel material was shown to undergo color change upon heating to 54 °C from blue to white. The appearance of white color on the gel is a clear indication of nanoparticle to enhance the ultrasound energy to increase the temperature of gel. Nanoparticle presence within a solid causing increased heating upon ultrasound exposure, as detected through thermochromicity, is reported for the first time.
Conclusion

Even small nanoparticles can have significant interaction with ultrasound to lead to temperature rise in the medium. Therefore, the selective killing of cancer cells more than normal cell should be primarily from heating instead of cavitation since cancer cells in general cannot survive in higher temperature than normal cells. Cavitation should lead to the killing of both cancer and normal cells due to the release of a large amount of energy in the process. Direct three-dimensional detection of ultrasonically induced heating in a nanoparticle bearing tissue-mimicking gel becomes feasible.
The Association Between Non-prescription Analgesic Drug Use in Pregnancy and Neurodevelopmental Disorders: Protocol for an Umbrella Review
Authors: Kwok Janell , Hall Hildigunnur Anna , Murray Aja Louise , Auyeung Bonnie
Published: May 2020

BackgroundMaternal prenatal health has been shown to bean important influence on children’s developmental outcomes, which has led to an increased emphasis onprovidingmore information to supportclinical decisions in pregnancy. Several systematic reviewssuggest that analgesic drug use during pregnancy may haveneurodisruptive properties. However, no firm conclusions have yet been drawn onthe associations between prenatal analgesic drug use and children’s long-term development of neurodevelopmental disorderssuch as Autism Spectrum Disorder (ASD) or Attention-Deficit Hyperactivity Disorder (ADHD). Therefore, an umbrella review is proposed for the purpose of examining the associations between maternal analgesic drug use during pregnancy and diagnoses of neurodevelopmental disorders.MethodsIncluded systematic reviews will consist of studies examining the effect of maternal prenatal non-prescription analgesic drug use on children’s neurodevelopmental disorder status. Examined drugs will be restricted to those readilyaccessible and frequently used by pregnant women, and with characteristics that allow them to cross the placenta and directly affect fetal development. Outcomes will be restricted to formal clinical diagnoses of ASD and/or ADHD. Two reviewers will independently identify eligible reviews from six databases and a manual search of reference lists, consultation with field experts, and scan of pre-print archives.A third researcher will be consulted when consensus cannot be reached.Search strategy and data extraction will be based on the preferred reporting items for systematic review and meta-analysis (PRISMA) protocol and PRISMA-P checklist. Extracted data will also include short qualitative summaries by both reviewers. As part of quality assessment, astandardised measurement tool to assess systematic reviews (AMSTAR 2) will be used. A narrative synthesis is proposed to integrate findingsfrom different, potentially methodologically heterogeneousstudies. DiscussionThis umbrella review of associations between maternal prenatal use of non-prescription analgesic drugs andchildren’s neurodevelopmental disorders could allow for firmer conclusions to be drawn through the synthesis of all relevant published research. The synthesis of findings using high-quality evidence couldprovide more accurate healthcare information on the long-term effects of analgesic drugs on neurodevelopment, to better guide future clinical decisions during pregnancy. This review will also allow gaps and methodological differences in the literature to be identified, informing recommendations for future research.Systematic review registrationPROSPEROregistration number CRD42020179216.
Epidemiological characteristics of 1385 primary sacral tumors in one institution in China
Authors: Wang Jun , Li Dasen , Yang Rongli , Tang Xiaodong , Yan Taiqiang , Guo Wei
Published: May 2020

Background: Primary sacral tumors (PST) are a rare group of skeletal tumors that can affect children and adults of all ages. Little is known about the epidemiological characteristics of PST in China.Methods: 1385 patients with primary sacral tumors, which had the clinical record at our bone tumor center from 2000 to November 2018 were analyzed.Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma of PST affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males.Conclusions: The large cohort of primary sacral tumors in our database may reveal their epidemiologic characteristics of primary sacral malignant and benign tumors in China and epidemiological feature of PST is fairly distinct from the mobile spine and extremities.
Total cholesterol, alanine aminotransferase and the risk of primary liver cancer: A population-based prospective study in China
Authors: Sun Miaomiao , Wang Wanchao , Wang Yiming , Cui Haozhe , Liu Xining , Liu Siqing , Cao Liying
Published: May 2020

Background: Previous studies have shown that serum total cholesterol(TC) and serum alanine aminotransferase(ALT) were associated with liver cancer risk, respectively. However, the common contribution of TC and normal-high ALT to primary liver cancer(PLC) has not been reported to date. We aim to assess the separate and joint effect of low TC level and normal-high ALT level on the risk of PLC, a large prospective cohort was conducted in our study. Method: The participants were divided into 4 groups via mismarch method according to TC[low level(-)/ non-low level(+)] and ALT[normal level(-)/ normal-high level(+)] status, and using the lower quartile(P25) value(4.24 mmol/L) of TC and the upper quartile(P75) value(22 U/L) of ALT as a cut point, respectively. Incident PLC was confirmed by review of medical records. Cox proportional hazards regression models and interactive additive models were used to evaluate whether the joint effect of low TC level and normal-high ALT level is associated with the risk of PLC. Results: During 1,248,895 person-years of follow-up, 298 participants were diagnosed with PLC among 114,972 subjects. TC＜4.24 mmol/L for the “TC(-)” group; TC≥4.24 mmol/L for the “TC(+)” group; ALT＜22U/L for the “ALT(-)” group; ALT≥22U/L for the “ALT(+)”. Compared with the “TC(+)” group and “ALT(-)” group, respectively, the adjusted hazard ratio(HR) and 95% confidence interval(95%CI) of “TC(-)” group for PLC risk was 1.71 (1.34-2.19) and of “ALT(+)” group for PLC risk was 1.52 (1.18-1.95). In combinatorial analysis, compared with the group of “TC(+) with ALT(-)”, the significant increased risk of PLC were observed in “TC(+) with ALT(+) group”(HR=1.45; 95%CI: 1.07-1.97), “TC(-) with ALT(-)” group(HR=1.64; 95%CI: 1.21-2.22) and “TC(-) with ALT(+)” group(HR=2.70; 95%CI: 1.84-3.96), respectively. The interaction term between “TC(-)” and “ALT (+)” on the risk of PLC was not significant(Pinteraction=0.26). Conclusions: Both low TC level and normal-high ALT level were strong predictors of PLC. Individuals with low TC level and normal-high ALT level, would extremely increase the risk of PLC.Trial registration: ChiCTR-TNRC-11001489. Registered August 24, 2011 (retrospectively registered)
Radiation-Induced Pelvic Colorectal Obstruction After Neoadjuvant Chemoradiotherapy and Sphincter-Saving Surgery for Rectal Cancer: Is IMRT Better?
Authors: Huang Shenghui , Chen Minghong , Wang Xiaojie , Chen Yuangui , Lu Xingrong , Jiang Weizhong , Huang Ying , Chi Pan
Published: May 2020

PurposeRadiation-induced pelvic colorectal obstruction (RIPCO) is a severe complication after neoadjuvant chemoradiotherapy (NCRT) and sphincter-saving surgery (SPS) with for rectal cancer. The incidence and risk factors remain unclear. This study aimed to evaluate the influences of anatomical and clinical parameters including radiation modalities on this complication.MethodsFrom 2010 to 2018, data from patients who received NCRT and SPS with a diverting stoma for rectal cancer were collected. Patients with clinical parameters and complete pelvimetric parameters associated with RIPCO were included for univariate and multivariate analyses. Receiver operating characteristic curves were used to calculate the best cutoff value.Results﻿A total of 726 patients with rectal carcinoma received NCRT and SPS with diverting stoma, and 157 patients had complete pelvimetric data. Eighteen of the 726 (2.5%) patients developed RIPCO. Eleven patients only received recreation of a diverting stoma, and four were cured by intersphincteric resection with reconstruction of anastomosis and diverting stoma. In multivariate analysis, BMI (P =0.001), sacral depth (P=0.046), and Intensity-modulated radiotherapy (IMRT) (P<0.001) were independent predictors. The cutoff values of BMI and sacral depth were 21.1 kg/m2 and 4.1 cm, respectively. IMRT was independently associated with a lower incidence of RIPCO (P<0.001). The four-factor scoring system showed that the sensitivity was 88.9%, and the specificity was 85.6%. The AUC was 0.921.ConclusionRIPCO is a rare but severe complication after SPS following NCRT. A BMI more than 21.1 kg/m2, a sacral depth less than 4.1 cm, and IMRT may decrease the risk of RIPCO.
Analysis of the Response Time to Involved-Field Radiotherapy in Primary Gastrointestinal Low-Grade B-Cell Lymphoma
Authors: Choi Kyu Hye , Lee Han Hee , Jung Seung-Eun , Park Kyung-Sin , O Joo-Hyun , Jeon Young-Woo , Choi Byung-Ock , Cho Seok-Goo
Published: May 2020

Background

Early-stage primary gastrointestinal (GI) low-grade B-cell lymphoma shows good therapeutic response to primary radiotherapy. However, there is no clear guideline for the evaluation of response to radiation therapy currently. The aim of this study was to analyze the relationship between the best response time and the clinical course after radiotherapy.

Methods

Patients who underwent radiotherapy for treatment of primary GI low-grade B-cell lymphoma from September 2007 to December 2018 at Seoul St. Mary's Hospital were included. Early responders were defined by best response within 6 months after radiotherapy, and delayed responders after 6 months. Clinical and pathological factors associated with delayed response and survival analyses were performed to investigate the recurrence and survival during follow-up.

Results

A total of 43 patients were evaluated and the number of gastric mucosa-associated lymphoid tissue and duodenal follicular lymphoma was 36 and 7, respectively. All of 43 patients showed complete remission to radiotherapy and the best response time after radiotherapy was a median of 3 months. There were 8 delayed responders with a median duration of 8.9 months. Early and delayed responders were characterized by a significant difference in depth of invasion beyond the mucosal layer.

Conclusions

Delayed responders did not show differences in oncological outcomes compared with early responders. They were allowed to watch and wait for an additional 6 to 12 months without further treatment.
“I would like to be part of the team distributing the kits because I have all the qualities” Formative research to inform the development of a peer-led HIV self-testing intervention to improve HIV testing uptake and linkage to HIV care among young people and adult men in Kasensero fishing community, Rakai, Uganda
Authors: Matovu Joseph KB , Nambuusi Aminah , Nakabirye Scovia , Serwadda David , Wanyenze Rhoda
Published: May 2020

Background Despite efforts to improve HIV testing and linkage to HIV care among young people and adult men, uptake rates remain below global targets. We conducted formative research to generate data necessary to inform the design of a peer-led HIV self-testing (HIVST) intervention intended to improve HIV testing uptake and linkage to HIV care among young people and adult men in Kasensero fishing community in rural Uganda. Methods This was a cross-sectional, qualitative study conducted in three study communities in Kasensero fishing community in Rakai district, Uganda, between May 6 – 10, 2019. Six single-sex focus group discussions (FGDs) comprising 7-8 participants were conducted with young men (15-24 years), young women (15-24 years) and adult men (25+ years). We collected data on people’s perceptions about HIVST and peer-led HIVST; potential acceptability of peer-led HIVST and suggestions on how to implement peer-led HIVST in the community. Peer-led HIVST was defined as an approach that uses a trained lay person to distribute HIVST kits to other people in the community. FGDs were audio-recorded with permission from the participants, transcribed verbatim and analysed manually following a thematic framework approach. Results Forty-seven participants (31 men and 16 women) participated in the FGDs. Across communities and age-groups, most participants mentioned that peer-led HIVST would be generally acceptable to people in the community but people will need support in performing the test due to fear of performing the test wrongly or failing to cope with HIV-positive results. Most participants felt that peer-led HIVST would bring HIV testing services closer to the community “because [the peer-leader] could be my immediate neighbour”, making it easier for people to obtain the kits at any time of their convenience as opposed to placing them at a health facility. Participants suggested that the peer-leader should be a permanent resident, accessible, trustworthy, and good at keeping secrets. Conclusion Our study shows that peer-led HIVST is potentially acceptable in the fishing community suggesting that this approach can help to improve uptake of HIV testing services among young people and adult men who are usually missed through conventional HIV testing services.
Global Prevalence and determinants of preoperative anxiety among surgical patients: A systematic review and Meta-analysis
Authors: Abate semagn , Chekole Yigrem , Basu Bivash
Published: May 2020

Background: Preoperative anxiety, otherwise managed preoperatively, can cause high rate of cardiac mortality, adverse effects during anesthetic induction and patient recovery which correlate with high postoperative pain, increased analgesic and anesthetic consumption, prolonged hospital stay, poor quality of life decrease satisfaction with perioperative care. Objective: The systematic review and meta-analysis aimed to provide evidence on global prevalence and determinants of preoperative anxiety among surgical patients Methods: A three stage search strategy was conducted on PubMed/Medline, Cochran, Science Direct and LILACS databases. Publication bias was checked with a funnel plot and objective diagnostic test was conducted with Egger's correlation and Begg's regression tests. Results: The global pooled prevalence of preoperative anxiety among surgical patients was 48% (95% confidence interval (CI): 39 to 47%, 28 studies, 14652 participants. The systematic review and Meta-Analysis revealed that preoperative anxiety was approximately 4 times more likely in patients who had fear of complications, RR = 3.53(95 % confidence interval (CI: 3.06 to 4.07, six studies). Conclusion: The review revealed that approximately fifty percent of patients experienced preoperative anxiety which entails the policy makers and health care stakeholders should implement mitigating strategies to prevent and manage preoperative anxiety.
Molecular Characteristics of Rickettsia in Ticks Collected Along the Southern Border of Mongolia
Authors: von Fricken Michael E. , Voorhees Matthew A. , Koehler Jeffrey W. , Asbun Carmen , Lam Brandon , Qurollo Barbara , Hogan Kathryn M. , Baasandagwa Uyanga , Jigjav Battsetseg , Schoepp Randal J.
Published: May 2020

Introduction: Tick-borne infectious dDermacentor and iseases represent a significant threat to public health, particularly in regions where individuals frequently enter tick habitats. This is especially true in Mongolia, where 26% of the population are pastoral herders whose lifestyle results in high risk of tick-borne diseases, which include Rickettsial diseases. In this study, ticks collected along Mongolia’s southern border were tested for the presence of Rickettsia spp. DNA to better understand the risk of this bacterial infection in the region. Methods: Dermacentor and Hyalomma ticks (n = 4,022) collected across southern Mongolia (aimags Bayankhongor, Dornogovi, Govi-Altai, Khovd, and Omnogovi) were pooled and tested for Rickettsia spp. by real-time PCR. Subsequent melt-curve analyses and Sanger sequencing were used to identify specific Rickettsia species. Results: Approximately 64% of the 786 tick pools tested positive for Rickettsia bacteria. Melt curve analyses identified between four and six different Rickettsia species circulating in these tick pools. Amplicon sequencing of the ompA gene from selected positive samples identified Rickettsia spp. that closely resembled R. raoultii and R. sibirica. Detection rates varied greatly by sampling region and tick genus. Dermacentor ticks from the Govi-Altai region had the highest maximum likelihood estimation (MLE) infection rate of 48.4% (95% CI: 41.7-56.5%) while Hyalomma ticks collected in Omnogovi had an MLE rate of 7.6% (95% CI: 6.2-9.2%). Conclusions: Multiple Rickettsia species were found to circulate at high rates within native tick species in southern Mongolia. Further studies are required to investigate the clinical burden of disease associated with these Rickettsia spp. in exposed Mongolian populations.
Clinical features of COVID-19 patients in one designated medical institutions in Chengdu, China
Authors: Zhou Gui , Tan Yun-Hui , Luo Jiang-Cuo , Lu Yi-Xiao , Feng Jing , Li Juan , Yang Yun-Mei , Chen Long , Zhang Jian-Ping
Published: May 2020

OBJECTIVE: To study the clinical characteristics of patients infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease (COVID-2019).METHODS: Data were collected from 20 patients admitted to the Pidu District People’s Hospital in Chengdu from January 26, 2020 to March 1, 2020 with laboratory-confirmed SARS-Cov-2 infection. Clinical data were collected using the World Health Organization (WHO) nCoV CASE RECORDFORM Version 1.2 28JAN2020, which includes parameters such as: temperature, epidemiological characteristics, social network, history of exposure, and incubation period. If information was unclear, the team reviewed the original data and contacted patients directly if necessary.RESULTS: The median age of the 20 COVID-19 infected patients studied was 42.5 years. In this cohort, four patients became severely ill and one deteriorated rapidly during treatment. This patient was transferred to another medical center with an intensive care unit (ICU) for treatment. This patient died after admission to the ICU. Two of the twenty patients remained positive SARS-Cov-2 more than three weeks, and they were quarantined in a medical facility without medication. According to our analysis, all of the studied cases were infected by human-to-human transmission due to the lack of protective measures; transmission through contact within families requires confirmation. The most common symptoms at onset of illness were fever in 13 (65%) patients, cough in 9 (45%), headache in 3 (15%), fatigue in 6 (30%), diarrhea in 3 (15%), and abdominal pain in 2 (10%). Six patients (30%) developed shortness of breath upon admission. The median time from exposure to onset of illness was6.5 days (interquartile range 3.25–9 days), and from the onset of symptoms to first hospital admission was 3.5 (1.25–7) days.CONCLUSION: Compared with patients infected with SARS-Cov-2 in Wuhan (up to the end of February 2020), the symptoms of patients in one hospital in Chengdu, Sichuan Province, were relatively mild and patients were discharged from the hospital after only a short stay. However, the fasting blood glucose of the infected individuals was found to be slightly elevated because of the state of emergency. The dynamic changes in lymphocyte levels can predict disease status of COVID-19. They are also suggestive of changes in mean platelet volume during disease progression. This suggests that the patients had mild cases of COVID-19. However, because there is no effective drug treatment for COVID-19, it is important to detect and identify severe cases from mild cases early.
Exploring customer intentions to adopt mobile banking services: evidence from a developing country
Authors: Akhter Ayeasha , Al Asheq Ahmed , Uzzal Hossain Md. , Mobarak Karim Md.
Published: May 2020

As the number of smart phone users and the popularity of Internet among people are growing day by day in Bangladesh, it became necessary for Bangladeshi local banks to provide mobile banking services to their customers. Therefore, this study seeks to identify the crucial and determining factors that may affect the intention of customers to use mobile banking services. The sample size in this study is 91, in which majority are the students of Business Studies. All respondents have mobile banking at the time of the survey. The samples in the study were mainly drawn from the private university students (i.e. Business Administration students) and faculty members, and some bank officers participated as sample respondents in this study. A non-probability random sampling method is applied, and a 5% significance level is used to accept the hypotheses. Cronbach alpha (α) of 0.7 and above is considered to measure the reliability of the item wise variables. This study examines six variables (perceived usefulness, perceived ease of use, trust, security, perceived privacy, and technology competency) to analyze their impact on the behavioral intention of banking customers to use mobile banking services. Three variables, namely perceived usefulness, security, and technology competency, are found to be significant predictors of customers’ intent to use mobile banking in Bangladesh. For analytical purposes, SPSS version 23.0 is used to test hypotheses. The paper also provides significant implications for bank managers to increase the adoption of mobile banking for their sustainability.
Variations in Baseflow Recession Curves as a Function of Land-Use Change in the Keduang Watershed, Wonogiri Regency, Jawa Tengah Province, Indonesia
Authors: Latuamury Bokiraiya , Talaohu Moda
Published: May 2020

Land-use change and its effects on hydrological processes in a watershed strongly determine the adopted land and water resource management. Human activities that lead to the conversion of forest to non-forest land can continue to modify hydrological systems. This study was intended to analyze the variation in baseflow recession curves as a function of land-use change in the Keduang Watershed, Wonogiri Regency, Jawa Tengah Province. The results showed that the types of land-use conversions had the same model of recession: Qmodel= 0.9747*Exp(-0.2357*ts) for preserved forests, Qmodel= 0.1266*Exp(-0.1238*ts), to represent the conversion of forests to agricultural areas, Qmodel= 0.1108*Exp(-0.1008*ts) for forests to settlements, Qmodel= 0.7628*Exp(-0.2015*ts) for unchanged agricultural areas, Qmodel= 0.0465*Exp(-0.1141*ts) for the conversion of agricultural areas back to forests, Qmodel= 0.1072*Exp(-0.0952*ts) for agricultural areas to settlements, and Qmodel= 0.3359*Exp(-0.1542*ts) for settlements. Overall, the equations indicate that forests can store water better and longer than converted to agricultural fields and settlements.
Comunidades virtuales para el aprendizaje. Su utilización en la enseñanza
Authors: Cabero Almenara Julio
Published: May 2020

En este artículo se analizan las posibilidades que pueden tener para al enseñanza las comunidades virtuales. Para ello en primer lugar se parte de una definición de lo que son las comunidades virtuales y cuáles son sus características más significativas. Al mismo tiempo se analizan que pueden garantizar su éxito de funcionamiento. El artículo finaliza analizando específicamente la función que cumplen en la formación, y los roles que profesor y alumno pueden jugar en las mismas.AbstractIn this article are analyzed the possibilities that can have the virtual communities for the teaching.  For it in first place begin of a definition of what are the virtual communities and which their more significant characteristics are. At the same time are analyzed what they can guarantee their operation success. The article concludes analyzing the function that virtual communities develop in formation, and the roles that teacher and student can play in the same ones.
Algunas consideraciones para integrar los recursos en una aplicación hipermedial. En busca de la mediación
Authors: Nazareno Boarin Mauricio , Cerda Ernesto Pedro
Published: May 2020

Este trabajo pretende realizar un aporte a todas aquellas personas interesadas en el análisis o elaboración de materiales hipermediales, posibles de ser usados en un contexto educativo. El mismo presenta algunas caracterizaciones básicas respecto de los medios que conforman un material hipermedial y en función de éstas, se brindan algunas consideraciones que facilitan la tarea de incluir e integrar texto, imagen, hipertexto, sonido y video a una aplicación del tipo. También se trabajan algunos criterios que colaboran con el fenómeno de mediación y que van mas allá de los recursos implicados en una hipermedia.AbstractThis work tries to make a contribution to all those people interested in the analysis or elaboration of hypermedial , possible materials of being used in an educative context.  The same one presents some basic characterizations respect to the means that conform a hypermedial material and based on these, offer some considerations that facilitate the task of including and of integrating text, image, hypertext, sound and video to an application of the type.  Also some criteria work that collaborate with the mediation phenomenon and which they go beyond of the resources implied in a hypermedia.
Internet en EGB y la necesidad de estrategias didácticas para el manejo eficiente de la información en la red
Authors: Ruiz Andrea María , Cataldi Zulma , Kraus Germán
Published: May 2020

Las NTIC (Nuevas Tecnologías de información y Comunicación) ofrecen una gran cantidad de recursos educativos que pueden ser utilizadas para los alumnos de la Educación General Básica (EGB). Dentro de ellos, la búsqueda de información en Internet se presenta como una estrategia que debe ser analizada específicamente para dar respuesta a las necesidades de los alumnos del 2do. Ciclo dela EGB, que dan sus primeros pasos en estas búsquedas. Por ese motivo, se deben incorporar formas de búsquedas significativas a fin de les permita aprender a aprender.Abstract The Information and Communication Technologies (ICTs) offer a great amount of educative resources for students attending to the General Basic Education (EGB) cycle. Among them, Internet as a source for searching information must be accurately analyzed as an answer to the specific needs of students of 2nd cycle of EGB that are giving their first steps in these quests and their particular features.
El proceso de virtualización en las disciplinas de la UNED
Authors: Santoveña Casal Sonia Mª
Published: May 2020

Un curso virtual es el resultado de un proceso de virtualización (establecimiento de protocolos didácticos y tecnológico y realización de unseguimiento de tareas) y de un proceso de control de calidad (control didáctico y funcional de los recursos publicados.AbstractA virtual course is the result of two processes: one of virtualization and other of quality control. The former consists in the settlement of didactic and technologic guides and the realization of a tasks follow-up. The latter requires the didactic and functional control of the publicized resources.
Algunos fundamentos filosóficos y psicológicos de la tecnología educativa
Authors: Verdecia Carballo Enrique
Published: May 2020

El presente trabajo tiene como objetivo describir el surgimiento de la tecnología educativa como tendencia pedagógica contemporánea y sus referentes filosóficos y psicológicos.En especial se hace énfasis en el impacto que ha producido la tecnología educativa sobre la educación cubana y desde que presupuestos filosóficos y psicológicos se ha asumido, sin dejar de tener en cuenta sus antecedentes históricos. AbstractThe technological development of the 1950s finally generated a whole educational revolution at world-wide level whose leading exponent is what today is known as distance learning.This paper aims at finding a way of describing the emergence of educational technology as a contemporary pedagogical tendency. It also describes its philosophical and pedagogical referents, since they have led the way to its present developments, even in distance learning. Our point of departure is the concept of skill (técnica) and its subsequent link with science, thus giving origin to the concept of technology, to later describe the way in which the latter gradually related to different cultural and social systems.Special emphasis is laid on the impact that educational technology has had on Cuban education and on the identification of the philosophical and psychological assumptions that have been its point of departure, taking into account its historical background.
Educación alternativa: Una propuesta de Prácticas y Evaluación de Aprendizajes
Authors: María Álvarez Margarita , Maldonado Marilena
Published: May 2020

La universidad está todavía en camino hacia la construcción de un proceso de enseñanza–aprendizaje–desarrollo, que posibilite la formación de individuos profesionales idóneos y competentes en un contexto social, económico y cultural en constante cambio.  Como un intento de superar este estado y de lograr aprendizajes significativos en los alumnos adoptamos la educación alternativa.En este artículo, se plantea una propuesta de distintos tipos de prácticas alternativas y criterios de evaluación para una asignatura. AbstractThe university is still in road toward the construction of a teaching-learning-development process that facilitates the formation of suitable and competent professional individuals in a social, economic and cultural context in constant change. As intent of overcoming this state and of achieving significant learning in the students we adopt the alternative education.   In this paper, we think about a proposal of different types of alternative practices and evaluation approaches for a curse.
Abriendo el aula. Blogs, una reflexión compartida sobre buenas experiencias de enseñanza
Authors: Ferreyro Juana
Published: May 2020

Este trabajo pretende contribuir a plantear el desafío que supone formar docentes en la nueva sociedad de la información y el conocimiento, señalar particularmente que “abrir el aula” supone un aspecto sustantivo para cualquier proceso educativo que pretenda tener iniciativa en el mundo contemporáneo y, finalmente, sugerir una propuesta accesible, viable y fundamentalmente enriquecedora para quienes participan de ella, la construcción de blogs sobre buenas prácticas de enseñanza.AbstractThis work tries to contribute to raise challenge which it supposes to form educational in the new society of the information and the knowledge, to indicate particularly that "to open the classroom" it supposes an aspect noun for any educative process that it tries to have initiative in the contemporary world and, finally, to suggest accessible, viable and fundamentally enriching a proposal for those who participates in her, the construction of blogs on good practices of education.
Estrategia para el Desarrollo Autónomo de Habilidades Lógico Matemáticas mediante Actividades Colaborativas en Línea
Authors: Carabali O. Mauricio A.
Published: May 2020

La enseñanza de la matemática a lo largo de los años ha sido objeto de estudio y de referencia para conocer y evaluar distintas teorías y métodos de instrucción en beneficio de los estudiantes y su relación con esta asignatura. La investigación desarrollada presenta los resultados de un estudio realizado a los distintos actores de la educación en el Instituto Educacional Juan XXIII, ubicado en la ciudad de Valencia. Se realizó una encuesta a estudiantes del séptimo grado de educación básica de la institución, sus representantes, profesores de la cátedra de matemática y los directivos del mismo instituto para conocer su visión de la materia matemática así como su posible alcance en el desarrollo de habilidades lógico-matemáticas a partir del uso de nuevas tecnologías, para construir una comunidad virtual que estimule el aprendizaje colaborativo. Se obtuvieron resultados importantes, los cuales permitieron desarrollar una propuesta a la institución que incluyó seguir sus lineamientos en estándar educativo como lo es el del programa de los años intermedios (PAI), así como también desarrollar los conceptos y metodologías instruccionales del Diseño hacia Atrás y la Enseñanza para la Comprensión. Esta propuesta tuvo como plataforma guía a Moodle, la cual se propone sea incorporada como tecnología de punta para el desarrollo de estrategias de aula en apoyo al docente en sus actividades matemáticas diarias, a fin de lograr alcanzar la comprensión y habilidad matemática en el alumnado.AbstractMathematics education throughout the years has been object of study and reference to know and to evaluate different theories and methods of instruction in benefit of the students and its relation with this subject. The developed investigation presents the results of a study made to the different actors in education at the Educational Institute Juan XXIII, located in the city of Valencia, Venezuela. Seventh grade students, their parents, professors of the mathematical chair and the directors of the same institute, were surveyed to know their vision of math courses as well as its possible influence in the development of logical-mathematics abilities with the help of new technologies, to construct a virtual community that stimulates the collaborative learning. Important results were obtained, which allowed to develop a proposal to the institution following its guidelines in educative standard like the interval years program (PAI), and as well to develop the concepts and instructions methodologies of the Backwards Design and the Education for Understanding. This proposal has Moodle as platform, which is intended to be incorporated as state of the art technology for the development of classroom strategies to support teachers in their daily activities, in order to reach the understanding and mathematical ability in the pupils.