bluuebunny/crossref_metadata_2025 huggingface dataset:
Kekurangan Aplikasi Grammarly dalam Mendeteksi Kesalahan pada Karya Tulis Mahasiswa
Authors: Tambunsaribu Gunawan , Galingging Yusniaty
Published: March 2024

Kehadiran aplikasi aplikasi hasil kecerdasan buatan (artificial inteligence) di jaman sekarang tidak akan bisa kita hindari. Dalam keseharian kita saat ini, kecerdasan buatan sangat membantu kita dalam menyelesaikan pekerjaan kita. Penelitian ini membahas tentang jenis kekurangan yang dimiliki oleh aplikasi Grammarly sebagai mesin pemeriksa kesalahan tulisan dalam sebuah naskah. Penelitian ini juga memberikan informasi mengenai langkah-langkah atau solusi yang dilakukan manusia, sebagai penulis, untuk mengatasi kekurangan yang dimiliki oleh aplikasi Grammarly. Penelitian menggunakan metode kualitatif. Data dalam penelitian kualitatif berupa kata, frasa, klausa dan kalimat dalam tulisan ilmiah mahasiswa di jurusan Sastra Inggris, Universitas Kristen Indonesia. Analisis data didapatkan oleh peneliti dari hasil observasi peneliti terhadap uji coba penggunaan aplikasi Grammarly. Peneliti melakukan teknik analisis konten. Dalam hal ini peneliti menjelaskan setiap jenis contoh kesalahan penulisan yang dideteksi oleh Grammarly serta penjelasan mengenai langkah-langkah yang dilakukan peneliti dalam memperbaiki kesalahan tersebut. Dari penelitian ini dapat ditemukan bahwa ada beberapa kesalahan penulisan yang bisa dideteksi oleh aplikasi Grammarly yaitu: a. pengetikan huruf (typo); b. kekosongan tanda baca; c. pillihan kata tidak tepat; d. spasi tidak tepat atau berlebihan; e. kalimat bermakna tidak jelas atau ambigu; f. kalimat berstruktur tidak lengkap. Dari temuan ini, penulis menyimpulkan bahwa secanggih teknologi kecerdasan buatan manusia (artificial intelligence), manusia yang akan selalu melakukan penyempurnaan secara manual. Penulis berharap bahwa penelitian dengan topik pembahasan mesin pemeriksa kesalahan penulisan bisa dilanjutkan di kemudian hari oleh peneliti lainnya agar dapat memberikan perbandingan kualitas antara beberapa aplikasi sehingga memberikan banyak pilihan kepada penulis untuk memeriksa kesalahan dalamnaskah tulisannya.

Kata kunci: aplikasi Grammarly, kesalahan penulisan, kecerdasan buatan
EFFECTS OF TIKTOK ENGLISH TEACHING VIDEOS IN THE SECOND LANGUAGE ACQUISITION OF ELEMENTARY LEARNERS
Authors: De Matta Shaina Mae S. , Ibaite Xamiela A. , Revistual Noreen Ann S. , Fajardo Dan Fereth
Published: March 2024

This study aimed to examine the Effects of TikTok English teaching videos in the Second Language Acquisition of Elementary Learners. The participants of this study were the 21 intermediate learners in Nababarera Elementary School, Baao, Camarines Sur. The researchers came up with the three main questions in this study: (1) What is the level of Second Language Acquisition of elementary learners during: a. Pre-Assessment b. Post-Assessment (2) Is there a significant difference between the raw scores of pre-assessment and post-assessment? (3) What are the challenges encountered in utilizing mobile phones as a tool for second language acquisition? The researchers used mixed-method approach to answer the research questions. A pre- and post-assessment and a semi-structured interview were used as tools. It is discovered that learners who use mobile devices for language learning experience learning setbacks due to physical, pedagogical, and psycho-social issues. The result also showed that there is a significant difference between the raw scores of the learners’ pre- and post-assessment. Hence, TikTok can be an assessment tool for evaluating learners' language learning progress and an out-of-class learning tool to motivate and engage students in their English language skills development.
GANGGUAN BERBAHASA PADA ANAK USIA 10 TAHUN
Authors: Sidebang Patrisia Deni , Gafari Oky Ferdian , Puteri Anggi , Adisaputera Abdurrahman
Published: March 2024

Based on Reza's medical history and development, there are indications that the language disorder he experienced is related to the presence of a medical history at birth, namely tongue-tie or ankyloglossia. Where when Reza was just born there was a kind of binding or barrier on the tongue so that the range of motion of the tongue was not free. Based on observations from his medical history, Reza experienced tongue-tie where he became difficult to stick out his tongue and became one of the causes of being slurred. In addition, tongue-tie also affects the way Reza eats, speaks, and swallows. In this study, qualitative methods were used by applying interview techniques to Reza's parents and also making observations when Reza communicated with his environment. The main goal is to obtain in-depth data on the language disorders experienced by the ten-year-old child. The limited pronunciation of R experienced by Reza makes it difficult for him to pronounce some words related to the letter R. This then makes the words and sentences spoken by Reza sound strange and incorrect. So he becomes difficult to communicate with his peers. To overcome these limitations, Reza took the initiative to write them on paper or on the ground when playing together.this limitation also did not become an obstacle for Reza to make friends and adjust, because some of his playmates had often communicated with him so that conversations between them seemed to run smoothly and well even though sometimes there were still moments between them that were difficult to understand the meaning of Reza's sentence. Limitations in language learning are things that need to be considered, so a special approach is needed in providing language training that is in accordance with Reza's conditions. With regular learning carried out every day with the surrounding environment, it is hoped that Reza will experience an improvement in his communication skills and also expected environmental awareness of Reza's condition.
POLA KOMUNIKASI DAN DISTORSI TUJUAN TRADISI MADIHIN KALIMANTAN SELATAN
Authors: Muttaqin Ahmad Imam
Published: March 2024

Tradisi Madihin yang tumbuh dan berkembang di Kalimantan Selatan merupakan sebuah media penyampaian pesan dan nasihat namun dikemas dalam bentuk hiburan. Berbentuk pantun yang disusun sedemikian rupa dan dituturkan dengan alunan khas Madihin serta diiringi dengan tabuhan rebana. Namun, tujuan pelaksanaan Madihin kini semakin terdistorsi dengan banyaknya pihak yang tidak mengetahui tujuan pelaksanaan Madihin, mereka hanya menganggap Madihin sebagai hiburan. Penlitian ini bertujuan untuk mengetahui pola komunikasi dalam Madihin dan untuk mengetahui keberadaan distorsi tersebut. Sebagai dasar dari penelitian ini digunakan teori etnografi komunikasi milik Muriel Saville Troike yang memuat ciri suatu tindak tutur dan berbagai hal yang menyertai tindak tutur tersebut. Dalam penelitian ini digunakan metode wawancara terhadap 2 orang pamadihinan dengan teknik simak catat. Hasil penelitian menunjukkan bahwa terdapat distorsi tujuan tersebut yang dapat dilihat dari maraknya unggahan tentang Madihin di media sosial. Juga ditemukannya pola komunikasi Madihin yang kebanyakan ditentukan oleh setting dan participants. Pada penelitian ini juga ditemukan adanya distorsi dari tujuan semula madihin sebagai sebuah media nasehat, informasi, dan doa serta pujian menjadi hanya sebatas sebuah hiburan dengan memuat kalimat-kalimat yang tidak ada nasehat ataupun informasi bermanfaat di dalamnya, hanya murni sebatas kalimat-kalimat biasa yang dilantunkan dengan nada khas madihin dan diiringi dengan alunan tabuhan tarbang.
CITRA PEREMPUAN DALAM POSTER FILM HOROR INDONESIA: KAJIAN SASTRA FEMINIS
Authors: Isnaini Heri
Published: March 2024

Poster film digunakan sebagai bagian iklan dan promosi sebuah film. Studio akan mencetak dan memasang poster-poster film agar manarik calon penonton. Adakalanya poster film dibuat bervariasi dengan bentuk visual dan teks yang menarik. Selain itu, foto-foto aktor film juga ditampilkan dalam poster dengan pose yang menarik. Pada genre film horor, poster film yang disajikan seharusnya hanya mengandung simbol-simbol kemistisan, kengerian, ketakutan, dan kegayatan. Akan tetapi, pada poster-poster film horor Indonesia, simbol-simbol tersebut ditambah juga dengan tubuh perempuan sensual yang disajikan sebagai objek yang abjek. Tubuh perempuan sensual pada poster film horor Indonesia menunjukkan citra perempuan yang terabjeksi secara visual. Dengan begitu, konteks penelitian ini menyajikan tanda-tanda visual dalam poster film horor dengan kerangka semiotika. Teori yang digunakan dalam penelitian ini adalah teori kajian sastra feminis yang berusaha menempatkan perempuan pada posisi seharusnya dalam kerangka masyarakat yang patriarki melalui sistem tanda dan simbol. Hasil penelitian menunjukkan bahwa citra perempuan pada poster film horor Indonesia dapat diklasifikasi menjadi (1) citra perempuan yang sensual; dan (2) objek fetis yang metonimi. Keduanya berkelindan pada sistem ekonomi kapitalisme dengan berlindung pada poster film horor yang pada akhirnya hanya sebagai ajang untuk memosisikan perempuan sebagai objek tanda yang abjek dalam konstelasi sistem patriarki.

Kata kunci: Citra perempuan, film, horor, poster, sastra feminis, semiotika
An AN ANALYSIS OF PAUSES IN CONVERSATIONS BY STUDENTS OF THE FACULTY OF LETTERS AND LANGUAGES, UNIVERSITAS KRISTEN INDONESIA
Authors: Mulyohartono Christyanto Fernandez , YulesOrlandoSianipar
Published: March 2024

This article discusses about pauses phenomenon and the factors that cause pauses among students of the Faculty of Letters and Languages, Universitas Kristen Indonesia. This article was made by using qualitative research methods and using the theory of Reed and Kahar. Data is taken from recorded transcripts of online classes. Then, the data regarding the pauses phenomenon will be classified according to the types of pauses based on Reed and Kahar's theory. After that, the factors or causes of the pauses phenomenon will be analyzed. The results showed that there were 51 data on pauses (41 data filled pauses and 10 data unfilled pauses), which means that there are many students of the Faculty of Letters and Languages, Universitas Kristen Indonesia who do the pauses for various reasons, ranging from nervousness, hesitation, and etc. In conclusion, the students from the Faculty of Letters and Languages, Universitas Kristen Indonesia use filled pauses more than unfilled pauses for reasons of nervousness and hesitation when they are talking. It is suggested that the students have to read more and practice speaking English regularly, increase English vocabulary, and the lecturers can also motivate students to practice so that they can minimize their pauses.
Pengaruh Insentif dan Pelatihan terhadap Kinerja Karyawan Bank Syariah Syariah Mandiri Kantor Cabang Balikpapan
Authors: Syarif Ahmad
Published: March 2024

Human resources are one of the most important assets of a company. Improving the quality of human resources aims to improve employee performance in a productive and professional manner. Employee contributions can have an impact on the company because if an employee performs well, they will also make a good contribution. The company's provision of salaries in the form of incentives and training is aimed at improving the performance of Branch Office of Bank Syariah Mandiri’s employees at Balikapapn. Therefore, this study aims to examine the effect of incentives and training on employee performance. This study uses quantitative methods with a number of respondents up to 45 employees of Bank Syariah Mandiri. This study uses multiple linear regression. In some cases, incentives have no effect on employee performance, while the provision of training has a significant positive effect on employee performance.
Analisis Kualitas Layanan dan Kepercayaan Terhadap Kepuasan Konsumen yang Berimplikasi pada Loyalitas Pelanggan Gofood di Kota Bekasi
Authors: Indrawati Budi , Wijayanti Murti , Yuniarti Triana
Published: March 2024

The existence of GoFood makes work more efficient, because people can get the food they want through their cellphones wherever they are, both at home and outside the home. From the quality of service that can meet the wishes and expectations as well as trust, it will have an impact on the creation of customer satisfaction and customer loyalty. The purpose of this study was to determine the effect of the variable Service Quality and Consumer Trust on Customer Satisfaction which has implications for GoFood Customer Loyalty in Bekasi City. Quantitative research methods using Smart PLS 3 data processing. The sample used 100 respondents with purposive sampling technique. The results and conclusions show that there was an effect of Service Quality and Consumer Trust on Customer Satisfaction; there is an effect of Consumer Trust and Customer Satisfaction on Customer Loyalty; Customer Satisfaction mediates between Service Quality and Customer Loyalty; Service Quality has no effect on Customer Loyalty, and Customer Satisfaction does not mediate between Consumer Trust and Customer Loyalty. The results can be input for GoFood management and partners.
Successfully remembering a belief and the problem of forgotten evidence
Authors: Sakuragi Shin
Published: March 2024

The problem of forgotten evidence consists of a pair of scenarios originally proposed by Alvin Goldman. In the “forgotten good evidence” and “forgotten bad evidence” scenarios, subjects hold the same memory belief while irreversibly forgetting its original, though different, pieces of evidence. The two scenarios pose a series of challenges to current time slice (CTS) theories, which posit that memory beliefs are justified solely by contemporaneous states. Goldman’s two scenarios pose an apparent dilemma to CTS theories given a naïve picture of how a memory belief is successfully retained while its evidence is irreversibly forgotten. In my view, however, CTS theories may find a solution to the apparent problem by carefully examining the conditions under which a memory belief is successfully retained while its evidence is completely forgotten. Namely, the two scenarios overlook an important difference between forgetting good evidence and forgetting bad evidence.
Rejecting the Use of Thought Experiment Results in Physics
Authors: Soltani Abolfazl
Published: March 2024

In physics, whenever we cannot do an experiment in the real world for physical, technological, financial or ethical reasons, we use "thought experiment". In this letter, we prove that sometimes a thought experiment may lead us to the wrong results; and so, to achieve the definitive and reliable results, all experiments must be done in the real world. This means rejecting the use of the results of intellectual analysis of an experiment, namely thought experiment.
KEPUTUSAN KEUANGAN DAN IMPLIKASINYA TERHADAP PROFITABILITAS DAN NILAI PERUSAHAAN
Authors: Murniati Sitti
Published: March 2024

Tujuan penelitian ini adalah menganalisis pengaruh keputusan keuangan yang terdiri dari keputusan investasi, keputusan pendanaan dan kebijakan dividen serta implikasinya terhadap profitabilitas dan nilai perusahaan pada perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia. Metode penelitian ini adalah explanatory research dengan pengumpulan data dilakukan melalui teknik dokumentasi berupa laporan keuangan perusahaan selama 5 tahun, periode tahun 2012 sampai tahun 2016 dengan jenis riset pooling data yaitu penggabungan antara data time series dan cross section. Subyek penelitian adalah perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia. Teknik analisis data dalam penelitian ini menggunakan Analisis Jalur (Path Analysis) dengan SPSS Versi 21. Hasil penelitian ini menunjukkan bahwa 1) pengaruh langsung dan tidak langsung keputusan investasi terhadap profitabilitas dan nilai perusahaan adalah signifikan dan pengaruh keputusan investasi melalui profitabilitas terhadap nilai perusahaan adalah tidak signifikan, 2) pengaruh langsung keputusan pendanaan terhadap profitabilitas adalah signifikan sedangkan pengaruh langsung terhadap nilai perusahaan adalah tidak signifikan serta pengaruh keputusan pendanaan melalui profitabilitas terhadap nilai perusahaan adalah signifikan, dan 3) pengaruh langsung dan tidak langsung kebijakan dividen terhadap profitabilitas dan nilai perusahaan adalah tidak signifikan, dan pengaruh kebijakan dividen melalui profitabilitas terhadap nilai perusahaan adalah tidak signifikan.
PENGAKUAN DAN PENGUKURAN PENDAPATAN PADA PT. NUSANTARA TERMINAL SERVICE MAKASSAR
Authors: Basar Nur Fatwa , Aisyah Nur
Published: March 2024

Penelitian ini bertujuan untuk mengetahui apakah pengakuan dan pengkuran pendapatan PT. Nusantara Terminal Services Makassar telah sesuai dengan pengakuan dan pengukuran pendapatan menurut Pernyataan Standar Akuntansi Keuangan (PSAK) No. 23 tahun 2017?. Jenis data yang digunakan adalah data kualitatif dan data kuantitatif. Sumber data yang digunakan adalah data primer dan data sekunder. Metode analisis yang digunakan dalam penelitian adalah deskriptif komparatif, yaitu metode analisis yang bersifat menggambarkan dan membandingkan persamaan dan perbedaan dua atau lebih kenyataan atau keadaan-keadaan atas suatu objek dalam bentuk uraian kalimat berdasarkan keterangan-keterangan dari pihak-pihak yang berhubungan langsung dengan penelitian ini. Metode pengumpulan data menggunakan metode wawancara dan observasi terkait penelitian. Penelitian dilaksanakan dalam 1 tahun. Hasil penelitian menunjukkan bahwa pengakuan dan pengukuran pendapatan PT. Nusantara Terminal Services Makassar dengan pengakuan dan pengukuran pendapatan menurut Pernyataan Standar Akuntansi Keuangan (PSAK) No. 23 tahun 2017 tidak sesuai hal ini dapat dilihat pada perbedaan pengakuan pendapatan dimana PT. Nusantara Terminal Services Makassar Pendapatan diakui pada saat invoice diterbitkan sedangkan pengakuan menurut Pernyataan Standar Akuntansi Keuangan (PSAK) No. 23 tahun 2017 Pendapatan diakui dalam periode akuntansi pada saat jasa diberikan.
ANALISIS PENGARUH BAURAN PEMASARAN DAN KUALITAS LAYANAN TERHADAP KEPUTUSAN NASABAH MENYIMPAN DANA PADA BANK UMUM SYARIAH DI MAKASSAR
Authors: Kapriani Kapriani
Published: March 2024

Penelitian ini bertujuan untuk mengetahui signifikansi pengaruh bauran pemasaran jasa dan kualitas layanan terhadap keputusan nasabah menyimpan dana pada Bank umum syariah di Makassar baik secara parsial maupun simultan. Dalam pengumpulan data dilakukan dengan wawancara dan angket, data yang terkumpul berupa data primer dan sekunder. Penelitian ini menggunakan metode incidental sampling dengan jumlah sampel 100 responden. Hasil penelitian menunjukkan bahwa berdasarkan analisis regresi linier berganda menunjukkan bahwa variabel bauran pemasaran jasa (X1) dan kualitas layanan mempunyai (X2) berpengaruh positif dan signifikan terhadap keputusan nasabah menyimpan dana pada bank Umum Syariah di Makassar. Berdasarkan perhitungan uji koefisien korelasi (R) diperoleh nilai R sebesar 0,827 menunjukkan adanya hubungan yang kuat. Nilai koefisien determinasi (R2) keputusan nasabah menyimpan dana dijelaskan oleh bauran pemasaran jasa dan kualitas layanan sebesar 0,683 atau sebesar 68,30 %. Berdasarkan hasil Uji t menunjukkan bahwa bahwa variabel bauran pemasaran jasa (X1) dan kualitas layanan (X2) berpengaruh signifikan terhadap keputusan nasabah untuk menyimpan dana pada bank umum syariah di Makassar. Uji F menunjukkan bahwa variabel bauran pemasaran jasa dan kualitas layanan secara simultan berpengaruh secara signifikan terhadap variabel keputusan nasabah menyimpan dana pada bank umum syariah di Makassar.
INFLUENCE OF MANAGERIAL OWNERSHIP AND INSTITUTIONAL OWNERSHIP OF FINANCIAL PERFORMANCE IN LISTED PULP AND PAPER COMPANIES IN INDONESIA EXCHANGE
Authors: Hanafie Hadriana
Published: March 2024

The objectives of this study are: 1) to find out and analyze the effect of managerial ownership on financial performance on Pulp and Paper companies listed on the Indonesia Stock Exchange, and 2) to determine and analyze the effect of institutional ownership on financial performance on Pulp and Paper companies listed on Indonesia stock exchange. Data collection was carried out through documentation techniques in the form of financial statements for 5 years from 2013 to 2017 with the type of data pooling research. Pulp and Paper company research subjects listed on the Indonesia Stock Exchange. The data analysis technique used in this study is the multiple regression equation. The results showed that 1) the results of the study indicated that the application of managerial ownership in the sample company had been effective so that it had an influence in helping the unification of interests between managers and owners that could motivate managers to take action to improve the company's financial performance and 2) the results of this study proved that investors the institution is unable to professionally monitor the development of its investment in a company, thus the level of control over actions and management performance is very lacking so that the potential for fraud that can harm the company cannot be suppressed
TINGKAT KEMANDIRIAN KEUANGAN PEMERINTAH DAERAH KABUPATEN DAN KOTA DI PROVINSI SULAWESI SELATAN
Authors: Akhmad Akhmad , Romadhoni Buyung , Diana Fina
Published: March 2024

Dalam era otonomi daerah ini, sangat dibutuhkan tingkat kemandirian keuangan dari masing-masing pemerintah daerah dalam rangka memajukan pembangunan di daerah. Penelitian bertujuan untuk mengetahui perkembangan kemandirian keuangan pemerintah daerah tingkat II yang ada di Sulawesi Selatan. Penelitian ini menggunakan data panel 24 daerah tingkat II yang ada di Sulawesi Selatan tahun 2015-2019. Metode analisis yang digunakan dalam penelitian ini adalah analisis rasio kemandirian keuangan. Hasil penelitian diperoleh bahwa tingkat kemandirian keuangan kabupaten dan kota di Sulawesi Selatan selama kurang waktu 2015 sampai 2019 secara umum mengalami peningkatan setiap tahunnya. Walaupun demikian tingkat kemandirian keuangan pemerintah daerah Tingkat II di Sulawesi Selatan relatif kecil hanya rata-rata sebesar 12,41 persen pada tahun 2019. Jauh lebih kecil dibanding dengan tingkat kemandirian keuangan rata-rata kabupaten dan kota secara nasional. Jadi pemerintah daerah tingkat II yang ada di Provinsi Sulawesi Selatan perlu menggali potensi penerimaan pemerintah daerah dengan tetap memperhatikan prinsip kewajaran agar tidak menimbulkan ekonomi biaya tinggi.
ANALISIS RASIO LIKUIDITAS SEBAGAI ALAT UNTUK MENGUKUR KINERJA KEUANGAN PADA PT UNITED TRACTORS TBK BURSA EFEK INDONESIA
Authors: Pasulu Milka , Gemini Pra
Published: March 2024

Rumusan masalah dalam penelitian ini adalah bagaimana kinerja keuangan dalam mengukur rasio likuiditas pada PT United Tractors Tbk di Bursa Efek Indonesia. Tujuan penelitian ini adalah untuk mengetahui kinerja keuangan dalam mengukur rasio likuiditas pada PT United Tractors Tbk di Bursa Efek Indonesia.Metode yang digunakan dalam penelitian ini adalah metode kuantitatif yang diperoleh dari dokumentasi resmi data yang telah dipublikasikan pada Bursa Efek Indonesia melalui situs resmi www.idx.co.id. Hasil penelitian ini menunjukkan bahwa, dari hasil perhitungan rata-rata rasio likuiditas pada PT United Tractors Tbk di Bursa Efek Indonesia dilihat dari nilai current ratio menghasilkan angka yang baik, cash ratio menghasilkan angka yang buruk, dan quick ratio menghasilkan angka cukup baik
ANALISIS ALOKASI DANA DESA DAN PENDUDUK MISKIN DI KABUPATEN GOWA
Authors: Nurmiati Nurmiati , Murbayani Murbayani , Lubis Bastian , Febrianti Magfirah
Published: March 2024

Penelitian ini bertujuan untuk menganalisis pengaruh alokasi dana desa terhadap penduduk miskin di Kabupaten Gowa khususnya di Desa Tanabangka Kecamatan Bajeng Barat Kabupaten Gowa. Penelitian ini termasuk penelitian survey dengan menggunakan kuesioner. Jenis penelitian ini merupakan penelitian deskriptif kuantitatif dengan populasi adalah penduduk miskin di Desa Tanabangka Kabupaten Gowa berjumlah 250 sedangkan jumlah sampel yang digunakan dalam penelitian ini adalah 72 orang. Analisis statistik yang digunakan dalam penelitian ini adalah menggunakan analisis regresi. Hasil penelitian menunjukkan bahwa semakin bertambahnya alokasi dana desa maka dapat menurunkan penduduk miskin di Desa Tanabangka Kecamatan Bajeng Barat Kabupaten Gowa.
PENGARUH BIAYA OPERASIONAL TERHADAP PENDAPATAN PADA UKM DODOL MONAS JAYA KABUPATEN MAROS
Authors: Syahrul Rika , Hanafi Muh Alam Nasyrah
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pengaruh biaya operasional terhadap pendapatan. Metode analisis yang digunakan dalam penelitian ini yaitu analisis regresi linear sederhana, koefisien korelasi, koefisien determinasi, dan uji hipotesis (uji t) dengan menggunakan perhitungan SPSS versi 24.Hasil penelitian dari analisis regresi linear sederhana diperoleh nilai persamaan regresi yaitu Y= 777887433.200+ 0.706x berarti apabila biaya operasional terjadi penurunan satu satuan maka pendapatan akan mengalami penurunan sebesar 0.706 dan koefisien korelasi sebesar 0,681 yang berada diantara 0,60- 0.799 yang menunjukkan bahwa hubungan biaya operasional dengan pendapatan yaitu kuat dan koefisien determinasi diketahui nilai koefisien determinasi sebesar 0.463 yang menunjukkan bahwa kebijakan dividen berpengaruh sebesar 46.3% terhadap pendapatan dan sisanya 53,7% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini, kemudian pengujian hipotesis (uji t) yaitu menunjukkan thitung = 3.710 ttabel = 2,353 maka hipotesis diterima, kemudian tingkat signifikan 0,206 0.05. Hal ini dapat disimpulkan bahwa variabel biaya operasional berpengaruh positif tetapi tidak signifikan terhadap pendapatan pada UKM Dodol Monas Jaya Kabupaten Maros.
AKUNTANSI PENJUALAN BERBASIS ONLINE PADA TRAVEL AGENT (Studi Kasus Almadera Hotel Makassar)
Authors: Aisyah Nur , Ramlah St. , Balfas Indriani
Published: March 2024

This study aims to determine the accounting for cash sales online travel agents at Almadera Hotel Makassar. The type of data used is descriptive qualitative and quantitative data. Sources of data used are secondary data and primary data. From the results of the study, it can be seen that the description for online cash sales such as traveloka and tiket.com by using an online cash sales accounting system can be seen from the related functions, documents used, accounting records used and procedures used.
Morte, luto e vestuário no ocidente
Authors: Godê Amanda Gazola , Grigoleto Netto Jose Valdeci
Published: March 2024

Desde os primórdios, a morte se faz presente na realidade humana e, devido a essa compreensão, é fato que nascer, crescer, viver e morrer fazem parte daquilo que consideramos ser o ciclo da vida. Ao longo da história, cada sociedade construiu práticas específicas no que diz respeito aos ritos fúnebres, sendo que isso é algo bastante particular e específico de cada cultura. Um destes ritos é a vestimenta, particularmente sendo adotada a cor preta nas culturas ocidentais como a representante do luto e do pesar. Neste caminho, com este estudo buscamos realizar uma reflexão sobre como os temas do luto e do vestuário se interseccionam e produzem efeitos nos espaços institucionais, sociais e subjetivos. Assim, trata-se de uma pesquisa de Revisão de Literatura realizada por meio de busca em base de dados como a Scientific Electronic Library Online - SCIELO e o Google Books, em que também foram utilizados livros e materiais físicos encontrados em obras que versam sobre a temática. Como resultado, através de uma leitura histórica, podemos encontrar indícios de que as vestimentas características do luto se originaram no contexto inglês do século XIX, por meio da Rainha Vitória, após a perda de seu cônjuge. Ainda, pode-se dizer que a opção pela vestimenta que representasse o luto e o sofrimento dava-se em sinal de respeito à pessoa que morreu, no sentido de que sua memória não seria esquecida. Como conclusão, pode-se afirmar que o luto possui seus atravessamentos nas esferas pessoais, sociais e culturais do sujeito, na medida em que o vestuário representante do luto, mesmo que não tão intenso na contemporaneidade, ainda apresenta efeitos e representações sociais.
Description of the viral community in fecal content of common carp (Cyprinus carpio) living in a naturally preserved wetland on Mexican plateau
Authors: Torres-Meza Oscar Abel , Godoy-Lozano Elizabeth Ernestina , Rico-Chávez Oscar , Loza-Rubio Elizabeth , García-Espinosa Gary
Published: March 2024

Introduction

The common carp (Cyprinus carpio) is a species that has been used worldwide as a source of protein for humans because of its adaptive capacity to the environment; however, it is also an invasive species. In Mexico, it was introduced to provide an easily accessible source of protein to people in rural areas until its extensive nationwide distribution. The community of viruses in these fish is not completely known.

Methods

Massive sequencing, i.e., whole metagenome shotgun (WMS) sequencing, and bioinformatic analysis were used to describe the viral community of common carp (Cyprinus carpio) living in a natural preserved wetland.

Results

Through sequencer Illumina NextSeq 500/550 we got 484,953,684 sequences from ten samples of fecal content of carp (5 samples to DNA and 5 samples to RNA). The virome comprised 30 viral families (13 DNA families and 17 RNA families), among which viruses related to vertebrates stood out, for example Orthoherpesviridae, Parvoviridae, Astroviridae, Poxviridae, Hantaviridae and Picornaviridae.

Discussion

The most abundant viral taxa corresponded to bacteriophages, most of which are of polyphyletic origin. The results of this work contribute to the knowledge of the different viral taxa found in the common carp in the wild and indicate that these viral taxa may play a role in health and productivity of fish farms.
Site-selective fatty acid chain conjugation of the N-terminus of the recombinant human granulocyte colony-stimulating factor
Authors: Wang Xu-Dong , Su Zhi-Hao , Du Jie , Yu Wei-Jia , Sun Wen-Long
Published: March 2024

The clinical application of the recombinant human granulocyte colony-stimulating factor (rhG-CSF) is restricted by its short serum half-life. Herein, site-selective modification of the N-terminus of rhG-CSF with PAL-PEG3-Ph-CHO was used to develop a long-acting rhG-CSF. The optimized conditions for rhG-CSF modification with PAL-PEG3-Ph-CHO were: reaction solvent system of 3% (w/v) Tween 20 and 30 mM NaCNBH3 in acetate buffer (20 mmol/L, pH 5.0), molar ratio of PAL-PEG3-Ph-CHO to rhG-CSF of 6:1, temperature of 20°C, and reaction time of 12 h, consequently, achieving a PAL-PEG3-Ph-rhG-CSF product yield of 70.8%. The reaction mixture was purified via preparative liquid chromatography, yielding the single-modified product PAL-PEG3-Ph-rhG-CSF with a HPLC purity exceeding 95%. The molecular weight of PAL-PEG3-Ph-rhG-CSF was 19297 Da by MALDI-TOF-MS, which was consistent with the theoretical value. The circular dichroism analysis revealed no significant change in its secondary structure compared to unmodified rhG-CSF. The PAL-PEG3-Ph-rhG-CSF retained 82.0% of the in vitro biological activity of unmodified rhG-CSF. The pharmacokinetic analyses showed that the serum half-life of PAL-PEG3-Ph-rhG-CSF was 7.404 ± 0.777 h in mice, 4.08 times longer than unmodified rhG-CSF. Additionally, a single subcutaneous dose of PAL-PEG3-Ph-rhG-CSF presented comparable in vivo efficacy to multiple doses of rhG-CSF. This study demonstrated an efficacious strategy for developing long-acting rhG-CSF drug candidates.
Physicochemical properties, pharmacokinetic studies, DFT approach, and antioxidant activity of nitro and chloro indolinone derivatives
Authors: Pirzada Abdul Saboor , Khan Haroon , Alam Waqas , Darwish Hany W. , Elhenawy Ahmed A. , Kuznetsov Aleksey , Daglia Maria
Published: March 2024

The process of developing of new drugs is greatly hampered by their inadequate physicochemical, pharmacokinetic, and intrinsic characteristics. In this regard, the selected chloro indolinone, (Z)-6-chloro-3-(2-chlorobenzylidene)indolin-2-one (C1), and nitro indolinone, (Z)-6-chloro-3-(2-nitrobenzylidene)indolin-2-one (C2), were subjected to SwissADME and density function theory (DFT) analysis. For compounds C1 and C2, the BOILED-Egg pharmacokinetic model predicted intestinal absorption, blood–brain barrier (BBB) penetration, and p-glycoprotein interaction. According to the physicochemical analysis, C1 has exceptional drug-like characteristics suitable for oral absorption. Despite only being substrates for some of the major CYP 450 isoforms, compounds C1 and C2 were anticipated to have strong plasma protein binding and efficient distribution and block these isoforms. The DFT study using the B3LYP/6-311G(d,p) approach with implicit water effects was performed to assess the structural features, electronic properties, and global reactivity parameters (GRP) of C1 and C2. The DFT results provided further support for other studies, implying that C2 is more water-soluble than C1 and that both compounds can form hydrogen bonds and (weak) dispersion interactions with other molecules, such as solvents and biomolecules. Furthermore, the GRP study suggested that C1 should be more stable and less reactive than C2. A concentration-dependent 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity was shown by both C1 and C2. In brief, this finding has provided a strong foundation to explore further the therapeutic potential of these molecules against a variety of human disorders.
Novel role of cardiovascular MRI to contextualise tuberculous pericardial inflammation and oedema as predictors of constrictive pericarditis
Authors: Giliomee L. J. , Doubell A. F. , Robbertse P. S. , John T. J. , Herbst P. G.
Published: March 2024

Tuberculosis (TB) and human immunodeficiency virus/acquired immunodeficiency syndrome have reached epidemic proportions, particularly affecting vulnerable populations in low- and middle-income countries of sub-Saharan Africa. TB pericarditis is the commonest cardiac manifestation of TB and is the leading cause of constrictive pericarditis, a reversible (by surgical pericardiectomy) cause of diastolic heart failure in endemic areas. Unpacking the complex mechanisms underpinning constrictive haemodynamics in TB pericarditis has proven challenging, leaving various basic and clinical research questions unanswered. Subsequently, risk stratification strategies for constrictive outcomes have remained unsatisfactory. Unique pericardial tissue characteristics, as identified on cardiovascular magnetic resonance imaging, enable us to stage and quantify pericardial inflammation and may assist in identifying patients at higher risk of tissue remodelling and pericardial constriction, as well as predict the degree of disease reversibility, tailor medical therapy, and determine the ideal timing for surgical pericardiectomy.
Cardiac defects of hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders: a retrospective cohort study
Authors: Knight Dacre R. T. , Bruno Katelyn A. , Singh Ayush , Munipalli Bala , Gajarawala Shilpa , Solomon Mahima , Kocsis S. Christian , Darakjian Ashley A. , Jain Angita , Whelan Emily R. , Kotha Archana , Gorelov David J. , Phillips Sabrina D. , Fairweather DeLisa
Published: March 2024

Background

Defective connective tissue structure may cause individuals with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD) to develop cardiac defects.

Methods

We conducted a retrospective chart review of adult patients treated in the EDS Clinic from November 1, 2019, to June 20, 2022 to identify those with cardiac defects. Echocardiogram data were collected using a data collection service. All EDS Clinic patients were evaluated by a single physician and diagnosed according to the 2017 EDS diagnostic criteria. Patient demographic, family and cardiac history were extracted from self-reported responses from a REDCap clinical intake questionnaire. Patients with at least 1 available echocardiogram (ECHO) were selected for the study (n = 568).

Results

The prevalence of aortic root dilation in patients with hEDS was 2.7% and for HSD was 0.6%, with larger measurements for males than females and with age. Based on self-reported cardiac history that was verified from the medical record, patients with hEDS with bradycardia (p = 0.034) or brain aneurysm (p = 0.015) had a significantly larger average adult aortic root z-score. In contrast, patients with HSD that self-reported dysautonomia (p = 0.019) had a significantly larger average aortic root z-score. The prevalence of diagnosed mitral valve prolapse in patients with hEDS was 3.5% and HSD was 1.8%. Variants of uncertain significance were identified in 16 of 84 patients that received genetic testing based on family history.

Conclusions

These data reveal a low prevalence of cardiac defects in a large cohort of well-characterized hEDS and HSD patients. Differences in cardiovascular issues were not observed between patients with hEDS vs. HSD; and our findings suggest that cardiac defects in patients with hEDS or HSD are similar to the general population.
Establishment and evaluation of a nomogram for in-hospital new-onset atrial fibrillation after percutaneous coronary intervention for acute myocardial infarction
Authors: Tu Junjie , Ye Ziheng , Cao Yuren , Xu Mingming , Wang Shen
Published: March 2024

Background

New-onset atrial fibrillation (NOAF) is prognostic in acute myocardial infarction (AMI). The timely identification of high-risk patients is essential for clinicians to improve patient prognosis.

Methods

A total of 333 AMI patients were collected who underwent percutaneous coronary intervention (PCI) at Zhejiang Provincial People's Hospital between October 2019 and October 2020. Least absolute shrinkage and selection operator regression (Lasso) and multivariate logistic regression analysis were applied to pick out independent risk factors. Secondly, the variables identified were utilized to establish a predicted model and then internally validated by 10-fold cross-validation. The discrimination, calibration, and clinical usefulness of the prediction model were evaluated using the receiver operating characteristic (ROC) curve, calibration curve, Hosmer-Lemeshow test decision curve analyses, and clinical impact curve.

Result

Overall, 47 patients (14.1%) developed NOAF. Four variables, including left atrial dimension, body mass index (BMI), CHA2DS2-VASc score, and prognostic nutritional index, were selected to construct a nomogram. Its area under the curve is 0.829, and internal validation by 10-fold cross-folding indicated a mean area under the curve is 0.818. The model demonstrated good calibration according to the Hosmer-Lemeshow test (P = 0.199) and the calibration curve. It showed satisfactory clinical practicability in the decision curve analyses and clinical impact curve.

Conclusion

This study established a simple and efficient nomogram prediction model to assess the risk of NOAF in patients with AMI who underwent PCI. This model could assist clinicians in promptly identifying high-risk patients and making better clinical decisions based on risk stratification.
Genomic analysis in Chilean patients with suspected Rett syndrome: keep a broad differential diagnosis
Authors: Brito Florencia , Lagos Catalina , Cubillos Jessica , Orellana Joan , Gajardo Mallen , Böhme Daniela , Encina Gonzalo , Repetto Gabriela M.
Published: March 2024

Introduction: Rett syndrome (RTT, MIM #312750) is a rare genetic disorder that leads to developmental regression and severe disability and is caused by pathogenic variants in the MECP2 gene. The diagnosis of RTT is based on clinical features and, depending on resources and access, on molecular confirmation. There is scarce information on molecular diagnosis from patients in Latin America, mostly due to limited availability and coverage of genomic testing. This pilot study aimed to implement genomic testing and characterize clinical and molecular findings in a group of Chilean patients with a clinical diagnosis of RTT.

Methods: Twenty-eight patients with suspected RTT underwent characterization of phenotypic manifestations and molecular testing using Clinical Exome SolutionTM CES_V2 by SOPHiA Genetics. Data was analyzed using the commercial bioinformatics platform, SOPHiA DDMTM. A virtual panel of 34 genes, including MECP2 and other genes that are in the differential diagnosis of RTT, was used to prioritize initial analyses, followed by evaluation of the complete exome sequence data.

Results: Twelve patients (42.8% of participants) had variants in MECP2, of which 11 (39.2%) were interpreted as pathogenic/likely pathogenic (P/LP), thus confirming the diagnosis of RTT in them. Eight additional patients (28.5%) harbored ten variants in nine other genes. Four of these variants were interpreted as P/LP (14.2%) (GRIN2B, MADD, TRPM3 and ZEB2) resulting in alternative neurodevelopmental diagnoses, and six were considered of uncertain significance. No evident candidate variant was found for eight patients.

Discussion: This study allowed to reach a diagnosis in half of the participants. The diagnosis of RTT was confirmed in over a third of them, while others were found to have alternative neurodevelopmental disorders. Further evaluation is needed to identify the cause in those with negative or uncertain results. This information is useful for the patients, families, and clinicians to guide clinical management, even more so since the development of novel therapies for RTT. We also show the feasibility of implementing a step-wide approach to genomic testing in a setting with limited resources.
Profiling antibody epitopes induced by mRNA-1273 vaccination and boosters
Authors: Girard Bethany , Baum-Jones Elisabeth , Best Rebecca L. , Campbell Thomas W. , Coupart Jack , Dangerfield Kyla , Dhal Abhilash , Jhatro Michael , Martinez Brian , Reifert Jack , Shon John , Zhang Minlu , Waitz Rebecca , Chalkias Spyros , Edwards Darin K. , Maglinao Maha , Paris Robert , Pajon Rolando
Published: March 2024

Background

Characterizing the antibody epitope profiles of messenger RNA (mRNA)-based vaccines against SARS-CoV-2 can aid in elucidating the mechanisms underlying the antibody-mediated immune responses elicited by these vaccines.

Methods

This study investigated the distinct antibody epitopes toward the SARS-CoV-2 spike (S) protein targeted after a two-dose primary series of mRNA-1273 followed by a booster dose of mRNA-1273 or a variant-updated vaccine among serum samples from clinical trial adult participants.

Results

Multiple S-specific epitopes were targeted after primary vaccination; while signal decreased over time, a booster dose after >6 months largely revived waning antibody signals. Epitope identity also changed after booster vaccination in some subjects, with four new S-specific epitopes detected with stronger signals after boosting than with primary vaccination. Notably, the strength of antibody responses after booster vaccination differed by the exact vaccine formulation, with variant-updated mRNA-1273.211 and mRNA-1273.617.2 booster formulations inducing significantly stronger S-specific signals than a mRNA-1273 booster.

Conclusion

Overall, these results identify key S-specific epitopes targeted by antibodies induced by mRNA-1273 primary and variant-updated booster vaccination.
CDKL3 shapes immunosuppressive tumor microenvironment and initiates autophagy in esophageal cancer
Authors: Bi Yanping , Liu Jie , Qin Songbing , Ji Fuqing , Zhou Chao , Yang Haihua , Zhou Suna
Published: March 2024

Background

CDKL3 has been associated with the prognosis of several tumors. However, the potential role of CDKL3 in immunotherapy and the tumor microenvironment (TME) in esophageal carcinoma (ESCA) remains unclear.

Methods

In this study, Cox regression analysis was used to assess the predictive value of CDKL3 for ESCA outcomes. We systematically correlated CDKL3 with immunological features in the TME. The role of CDKL3 in predicting the efficacy of immunotherapy was also analyzed. Correlation analysis, Cox analysis and LASSO Cox regression were used to construct the CDKL3-related autophagy (CrA) risk score model. The relationship between CDKL3 expression and postoperative pathological complete response (pCR) rate in esophageal squamous cell carcinoma (ESCC) patients undergoing neoadjuvant chemoradiotherapy (nCRT) was evaluated using Immunohistochemical staining (IHC). The relationship between CDKL3 expression and autophagy induction was confirmed by immunofluorescence staining and western blot, and the effect of CDKL3 expression on macrophage polarization was verified by flow cytometry.

Results

High expression of CDKL3 was found in ESCA and was associated with poor prognosis in ESCA. Moreover, CDKL3 expression was negatively correlated with tumor-infiltrating immune cells (TIICs), the integrality of the cancer immunity cycles, and anti-tumor signatures, while CDKL3 expression was positively correlated with suppressive TME-related chemokines and receptors, immune hyperprogressive genes, and suppressive immune checkpoint, resulting in immunosuppressive TME formation in ESCA. An analysis of immunotherapy cohorts of the ESCA and pan-cancer showed a better response to immunotherapy in tumor patients with lower CDKL3 levels. The CrA risk score model was constructed and validated to accurately predict the prognosis of ESCA. Notably, the CrA risk score of ESCA patients was significantly positively correlated with M2 macrophages. Furthermore, knockdown CDKL3 in KYSE150 cells could inhibit autophagy induction and M2 macrophage polarization. And, radiation could downregulate CDKL3 expression and autophagy induction, while ESCC patients with high CDKL3 expression had a significantly lower response rate after nCRT than those with low CDKL3 expression.

Conclusion

CDKL3 may play an important role in anti-tumor immunity by regulating autophagy to promote the formation of immunosuppressive TME, thus playing a critical role in the prognosis of ESCA.
Impact of programmed cell death protein 1 inhibitor therapy on the survival of patients with advanced or recurrent uterine cancers: a meta-analysis
Authors: Liang Keng-Wei , Chen Liang-Jou , Wang Chun-Hao , Ma Kevin Sheng-Kai , Hsia Li-Hsin , Wang Po-Hui
Published: March 2024

Introduction

No prior meta-analysis has investigated the impact of programmed cell death protein 1 (PD-1) inhibitor therapy on survival outcomes in patients with advanced or recurrent uterine cancers (including both corpus and cervical cancers).

Methods

A comprehensive search of PubMed and Embase databases was conducted, covering the past 10 years (up to August 2023) and encompassing all clinical research related to uterine cancer. Five randomized controlled trials and one cohort study met the inclusion criteria and were included in the meta-analysis. Data on patient demographics, clinical characteristics, treatment regimens, and survival outcomes were extracted. Hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS), as well as the relative risk of grade 3 or higher adverse events, were pooled using random-effects models.

Results

Patients receiving PD-1 inhibitors had better OS (HR, 0.65, 95% CI, 0.59–0.72; P<.001) and PFS (HR, 0.59, 95% CI, 0.49–0.70; P<.001) than those receiving variable non-PD-1 inhibitor therapies among 3452 uterine cancer patients. The leave-one-out meta-analysis of the HR of OS showed no individual study impact on the estimation of the overall effect size. Subgroup analysis revealed better OS in the PD-1 inhibitors use than the controls in cervical cancer (HR, 0.68, 95% CI, 0.59–0.79), endometrial cancer (HR, 0.62, 95% CI, 0.54-0.72), and pembrolizumab use (HR, 0.66, 95% CI, 0.57–0.75) subgroups. Patients with advanced cervical cancer, who had CPS > 1, receiving PD-1 inhibitors have statistically significant benefits in OS compared to controls (HR, 0.65, 95% CI, 0.53-0.80). The pooled HR for overall survival was 0.71 (95% CI, 0.60-0.82; P<.001) in patients who received PD-1 inhibitors as compared to those who did not receive PD-1 inhibitors in proficient mismatch repair (MMR) endometrial cancer patients. However, in deficient MMR patients, the HR was 0.30 (95% CI, 0.13-0.70). The relative risk of grade 3 or higher adverse events was not higher in the PD-1 inhibitor group (relative risk, 1.12, 95% CI, 0.98–1.27).

Conclusion

Survival was significantly better using PD-1 inhibitor therapy than variable non-PD-1 inhibitor chemotherapies among patients with advanced or recurrent uterine cancers.