bluuebunny/crossref_metadata_2025 huggingface dataset:
Bezugnahmen auf den Nationalsozialismus in der populären Musik: Lesarten zu Laibach, Death in June, Feindflug, Rammstein und Marduk, Reinhard Kopanski (2022)
Authors: Höpflinger Anna-Katharina
Published: September 2023

Review of: Bezugnahmen auf den Nationalsozialismus in der populären Musik: Lesarten zu Laibach, Death in June, Feindflug, Rammstein und Marduk, Reinhard Kopanski (2022)

Münster and New York: Waxmann, 528 pp.,

ISBN 978-3-83094-252-8, p/bk, €49.90

ISBN 978-3-83099-252-3, e-book, €44.99
Chicago Classification v4.0 Stratifies Acid Burden and Abnormal Impedance-pH Variables Better Than Chicago Classification v3.0 Chicago Classification v4.0 and GERD
Authors: Ribolsi Mentore , Marchetti Lorenzo , Savarino Edoardo , Gyawali C. Prakash , Cicala Michele
Published: September 2023

INTRODUCTION:

Gastroesophageal reflux disease (GERD) severity increases with esophageal body hypomotility, but the impact of Chicago Classification (CC) v4.0 criteria on GERD diagnosis is incompletely understood.

METHODS:

In patients with GERD evaluated with high-resolution manometry and pH-impedance monitoring, CCv3.0 and CCv4.0 diagnoses were compared.

RESULTS:

In 247 patients, hypomotility diagnosis decreased from 45.3% (CCv3.0) to 30.0% (CCv4.0, P < 0.001). In contrast, within patients with ineffective esophageal motility, proportions with pathological acid exposure increased from 38% (CCv3.0) to 88% (CCv4.0); baseline impedance and esophageal clearance demonstrated similar findings (P < 0.05 for each comparison).

DISCUSSION:

CCv4.0 hypomotility criteria are more specific in supporting GERD evidence compared with CCv3.0.
Association of dietary cholesterol intake with the risk of fatal cardiovascular events in individuals with type 2 diabetes
Authors: Kuntsevich A. K. , Rymar O. D. , Mustafina S. V. , Simonova G. I. , Shcherbakova L. V. , Verevkin E. G. , Shchetinina A. O. , Malyutina S. K.
Published: September 2023

BACKGROUND: Nutrition is one of the factors affecting the health of a population. One of the nutritional components in the diet is dietary cholesterol, which comes from meat products and eggs. To date, there is no unequivocal answer about the presence of a relationship between cholesterol consumption and the risk of cardiovascular diseases, which determines the relevance of the study of this issue.

AIM: To study the association of dietary cholesterol with the risk of fatal outcomes from cardiovascular disease (CVD) in individuals with type 2 diabetes mellitus (DM2).

MATERIALS AND METHODS: The baseline study was carried out within the framework of the HAPIEE project in 2003-2005. The period of observation of the cohort, incl. for persons with DM2 lasted from 2003- 2005 to December 31, 2018 and averaged 12.8 years, the average age for both sexes was 58.1±6.6 years. Data on actual nutrition were obtained from a survey of 678 participants using a questionnaire to assess the frequency of food intake and included information on 147 products. Statistical data processing was carried out using the SPSS v.13.0 application package. To compare independent paired groups of variables, the nonparametric Mann-Whitney U test was used. The risk ratio (HR) was estimated using Cox regression. The critical level of statistical significance of differences was taken at p<0.05.

RESULTS: It was found that in individuals with DM2, the risk of a fatal outcome from CVD in the maximum tertile of dietary cholesterol intake/1000 kcal increased by 56% compared with controls (p=0.009). An analysis of the consumption of chicken eggs/1000 kcal in the diet showed an increase in the risk of death from CVD in the maximum tertile of by 52% (p=0.003). Consumption of meat products/1000 kcal was not associated with the risk of death from CVD (p = 0.361).

CONCLUSION: In the surveyed cohort of Novosibirsk residents with a history of DM2, high dietary cholesterol levels (505 mg/day in the maximum tertile) in the diet were significantly associated with an increased risk of death from CVD. The results of this study may suggest a possible association of high-cholesterol foods with an increased risk of death in people with type 2 diabetes, pointing to the need for people with diabetes to control their dietary cholesterol levels and more optimal type of diet for this population.
Polymorphism of coagulation factor genes in patients with type 2 diabetes mellitus and chronic heart failure with retained ejection fraction
Authors: Sveklina T. S. , Shustov S. B. , Kolyubayeva S. N. , Kuchmin A. N. , Kozlov V. A. , Miroshnichenko O. A.
Published: September 2023

BACKGROUND. Patients with type 2 diabetes mellitus (DM2) have disorders of cellular and plasma hemostasis independent of the level of glycemia, increased platelet activation, combined with microvascular angiopathy. The study of the role of genetic markers of hemostasis disorders in the formation and progression of chronic heart failure (CHF) in patients with type 2 diabetes will allow for prevention, possibly optimize treatment and improve prognosis.

AIM. To reveal polymorphisms of genes of the hemostasis system in patients with type 2 diabetes mellitus and chronic heart failure with preserved ejection fraction.

MATERIALS AND METHODS. The frequency of coagulation factor genetic polymorphisms was studied in patients with CHF-pEF and DM2 (52 people), CHF with reduced ejection fraction (CHF-rEF) and DM2 (49) and healthy volunteers (66), mean age 69.9±10.1 years old. DNA was isolated from venous blood according to the method of the manufacturer. Genetic polymorphisms were determined by real-time polymerase chain reaction.

RESULTS. The frequencies of polymorphisms rs1799963 and rs6025 of the genes of blood coagulation factors F2 (prothrombin) and F5 (factor V of blood coagulation) in all three groups were insignificant and comparable in magnitude. In patients with CHF and DM2, the frequencies of the rs6046 polymorphism of the factor F7 gene in the heterozygous form were slightly higher (by 2.6 and 1.7 times, respectively) than in the control group, but the result was not statistically significant. The CHF-pEF and CHF-rEF groups differ in the frequencies of F13 (rs5985) and fibrinogen (rs1800790) genetic polymorphisms, but are more common in patients with CHF-rEF and DM2.

CONCLUSION. Based on the results of the study, it follows that the groups of CHF-pEF and CHF-rEF differ significantly in the frequencies of polymorphisms of the studied genes, both among themselves and with the control group. The highest frequency of polymorphisms of genes, the products of which are involved in the coagulation and cellular components of hemostasis, is observed in the group of patients with DM2 and CHF-rEF.
Early intensification of therapy for type 2 diabetes mellitus and achievement of the target level of glycohemoglobin HbA1c are necessary factors to reduce the risk of micro- and macrovascular complications
Authors: Shamkhalova M. S. , Sukhareva O. Y.
Published: September 2023

Control of type 2 diabetes mellitus (T2DM) requires multifactorial behavioral and pharmacological treatment to prevent the development or slow the progression of complications. The main characteristics of T2DM — hyperglycemia and insulin resistance, combined with oxidative stress, low-level inflammation, epigenetic changes, genetic predisposition, activation of the renin-angiotensin-aldosterone system, causing endothelial dysfunction, are responsible for the metabolic environment that increases vascular risk in patients. Almost all patients with type 2 diabetes are at high and very high cardiovascular risk. The largest studies of the late XX-early XXI centuries. demonstrated a significant reduction in complications with intensive care early in the course of the disease and a «legacy effect» with the long-term historical value of HbA1c control during their observational follow-ups. The decrease in HbA1c may also play a role in mediating the positive effect on cardiovascular risk observed with the use of new hypoglycemic agents. The desire for glycemic control and the desire for organ-specific protection are not mutually exclusive, but complementary. Reassessing individual glycemic goals and achieving them at regular intervals with early intensification of therapy is key to overcoming clinical inertia.
Entre o espírito público e o discurso político: as estratégias de comunicaçãoda pandemia no canal de Jair Bolsonaro no telegram
Authors: Lima de Sousa Francisco Sérgio , Vidal Nunes Márcia
Published: September 2023

Este artigo analisa a comunicação feita pelo ex-presidente brasileiro, Jair Bolsonaro, sobre a Covid-19. O corpus do estudo se circunscreve às mensagens publicadas pelo político no Telegram, durante os 100 primeiros dias de sua atuação na plataforma. Anali-samos o fenômeno a partir dos conceitos de comunicação pública e governamental (Duarte, 2007; Brandão, 2007, 2016; Oliveira, 2013) e comunicação política (Gerstlé, 2005; Freeman, 2019), confrontando-os com entendimentos sobre o populismo (Waisbord, 2018; 2020; Laclau, 2005; Jagers & Walgrave, 2007; Innerarity, 2015). O estudo utiliza como metodologia a análise de conteúdo (Benoit, 2011; Alonso, 2012; Sampaio & Lycarião, 2021). Os resultados mostram que Bolsonaro não produz comunicação pública ou governamental, mas sim comunicação política a partir de seu canal na plataforma, que é usado para estabelecer uma disputa narrativa pela construção de sentidos da população sobre a crise sanitária.
Examining the Factors Influencing the Intention to Use Electric Bikes by Young Adults: Using Extended Theory of Planned Behavior Model
Authors:   Professor, School of Management, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science & Technology, Tamil Nadu, India, Ravishankar K. , Subramani A. ,   Associate Professor, School of Management, Saveetha Institute of Medical and Technical Sciences, Tamil Nadu, India., Akbar Jan N. ,   Assistant Professor, Department of Human Resources and Soft Skills, ICFAI Business School (IBS), The ICFAI Foundation for Higher Education (IFHE), Hyderabad, Telangana, India., Ramkumar C. ,   Assistant Professor, Saveetha School of Management, Saveetha Institute of Medical and Technical Sciences, Tamil Nadu, India.
Published: September 2023

The study aims to examine the factors impelling young adults’ intention to use electric bikes (EB) to promote sustainable transportation in India. In this research, the theory of planned behavior (TPB) model is extended with environmental knowledge (EKL), environmental concern (ECN), and government policy support (GPS) to understand the intention to use (ITU) of young adults on electric bikes. Using a stratified random sampling technique, the survey was conducted among 354 electric bike users across major cities from Tamil Nadu, India. The PLS-SEM was used to analyze the conceptual model of the research. The findings of the research support that ECN, EKL, and GPS have a significant positive direct influence on young adults’ attitude (ATT) and an indirect effect on the intention to use (ITU) e-bikes. Among the three mediating variables, ATT and SJN mediate the relationship between ECN, EKL, and GPS on ATT and ITU of e-bikes. The study offered insightful recommendations to broaden the scope of research on electric bike sellers and manufacturers to plan sales and marketing strategies, for the government to make policy decisions, and ultimately to increase consumer interest in sustainable transportation.
The Influence of Cultural Differences on Gender Issues in Tourism and Hospitality Employment: A Grounded Theory Analysis
Authors:   Faculty of Business and Technology, Stamford International University, Vithayaporn Sanhakot
Published: September 2023

Gender issues involving job employment and promotion in the tourism and hospitality industry are influenced by cultural differences between individualism and collectivism. As many countries rely on revenue from tourism and hospitality, raising awareness of culturebased gender issues contributes to the sustainable development of this sector. Consequently, given the uncertainty and ambiguity surrounding these concepts, it is important to explore the functional mechanisms of cultural differences in gender issues. To this end, this study employed the grounded theory method to conduct semi-structured interviews of human resource managers of tourism organizations in various countries. It was concluded that four key factors—gender-based employment opportunities, gender-based job promotions, gender in leadership roles, and gender bias—are impacted by cultural differences in gender issues. These findings are discussed with the support of previous research, following which a theoretical framework is constructed to illustrate the significance of individualistic and collectivistic cultures' different perspectives on gender issues. This paper then explains the implications of the findings for scholarly and managerial fields, with a particular focus on the implications for the Asian business context. Finally, the limitations of the study are acknowledged, and recommendations for future research are provided.
ASUPAN ZAT GIZI MAKRO DAN MIKRO DENGAN KEJADIAN STUNTING PADA BALITA USIA 12-59 BULAN DI WILAYAH KERJA PUSKESMAS RADAMATA
Authors: Natara Adriana Inna , Siswati Tri , Sitasari Almira
Published: September 2023

ABSTRAKLatar Belakang: Stunting atau pendek masih menjadi masalah gizi di negara berkembang khususnya Indonesia. Nusa Tenggara Timur merupakan daerah dengan menyumbang tingginya kasus tersebut.Tujuan: untuk mengetahui hubungan asupan zat gizi makro dan mikro dengan kejadian stunting pada balita usia 12-59 bulan di wilayah kerja Puskesmas Radamata, Kabupaten Sumba Barat Daya, Nusa Tenggara TimurMetode: Penelitian ini merupakan penelitian observasional dengan desain kasus-kontrol (case-control) yang di lakukan dengan membandingkan dua kelompok yaitu kelompok kasus sebanyak 40 balita dan kelompok kontrol sebanyak 40 balita. Pengumpulan data meliputi asupan makan balita dengan pengisin kuesioner SQ-FFQ dan menghitung hasil asupan zat gizi mikro dan makro menggunakan program nutria survey kemudian hasil dirata-rata dan bandingkan dengan Angka Kecukupan Gizi (AKG).Penelitian ini menggunakan uji chi-squareHasil: Penelitian ini menunjukan bahwa ada hubungan signifikan antara stunting dengan asupan energi (p<0.05), asupan lemak (p<0,05) dengan nilai OR= 9.08 (95% CI=3.28-5.08) dan 3,56(95% CI 1,40 - 9,08). Balita memiliki risiko stunting 9.08 kali dan 3.56 kali lebih besar jika kekurangan asupan energi dan lemak.Simpulan: Dalam upaya penanggulangan stunting, sangat penting untuk memonitor asupan zat gizi makro khususnya jumlah energi dan lemak.
PERBEDAAN TINGKAT PENGETAHUAN GIZI, KETERSEDIAAN PANGAN RUMAH TANGGA, DAN KONSUMSI SAYURAN PADA MASYARAKAT PENERIMA P2KP DAN NON P2KP
Authors: Rasidin Rahmawati , Swamilaksita Prita Dhyani , Melani Vitria , Ronitawati Putri , Kuswari Mury
Published: September 2023

ABSTRAKLatar belakang: Kawasan Rumah Pangan Lestari (KRPL) merupakan bagian dari Program Percepatan Penganekaragaman Konsumsi Pangan (P2KP). Penerima program ini merupakan sekelompk wanita yang tergabung dalam kelompok wanita tani. Melalui program ini diharapkan masyarakat penerima program memiliki pengetahuan gizi yang lebih baik dan tercapainya ketahanan pangan di tingkat rumah tangga, terutama pada aspek ketersediaan dan konsumsi pangan, khususnya pada konsumsi sayuran.Tujuan: Mengetahui perbedaan tingkat pengetahuan gizi, ketersediaan pangan rumah tangga, dan konsumsi sayuran pada masyarakat penerima P2KP dan Non-P2KP.Metode: Penetian ini dilakukan pada bulan Maret 2021 – Agustus 2022 menggunakan analitik observasional dengan desain penelitian cross-sectional. Teknik pengambilan sampel purposive sampling sebanyak 43 penerima P2KP dan 43 Non-P2KP. Pengambilan data tingkat pengetahuan gizi menggunakan kuesioner pengetahuan gizi, pada ketersediaan pangan rumah tangga menggunakan kuesioner HFIAS (Household Food Insecurity Access Scale), serta konsumsi sayuran menggunakan kuesioner FFQ (Food Frequency Questionnaire). Analisis data menggunakan uji statistik t-test independen dan Mann-Whitney dengan tingkat kepercayaan 95%.Hasil: Pada penerima P2KP nilai rata-rata tingkat pengetahuan gizi sebesar 93,00 sedangkan pada Non-P2KP memiliki nilai rata-rata 82,10 yang menunjukkan ada perbedaan dengan nilai (p=0,001). Pada variabel ketersedian pangan rumah tangga penerima P2KP memiliki skor nilai rata-rata 2,27 dan Non-P2KP memiliki skor nilai rata-rata sebesar 5,18 dengan nilai (p=0,001). Pada variabel konsumsi sayuran, penerima P2KP mengonsumsi rata-arta 25,276 kali per bulan, sedangkan pada Non-P2KP 9,102 kali per bulan (p=0,001).Simpulan: Ada perbedaan tingkat pengetahuan gizi, ketersediaan pangan rumah tangga, dan konsumsi sayuran pada masyarakat Penerima P2KP dan Non-P2KP.
Spatial diversity of Village Funds in reducing Poverty in West Sumatra Province
Authors: Guswandi Guswandi , Amelia Siska
Published: September 2023

One of the efforts to improve the community's welfare and poverty alleviation requires an integrated development program and synergized based on local resources. One of the efforts is the village fund program, are funds provided for villages sourced from the state budget and are used for government administration, implementation of development and empowerment of village communities. This paper examines the spatial diversity of the effectiveness of the Village Fund in reducing poverty in West Sumatra Province from 2015 to 2020 (data from the Ministry of Finance). The unit of research analysis is the regency/municipal that receives the Village Fund assistance. This study uses Geographically Weighted Regression, with dimensions of observing the allocation of Village Funds and poor people. The study results show that the Village Fund cannot reduce poverty in the beneficiary regencies/municipals. The number of Village Funds disbursed increases every year, but the number of poor people also increases; only three districts, namely Limapuluh Kota, Pesisir Selatan, and Kepulauan Mentawai, have decreased in 2020. The Village Fund Program is ineffective in reducing poverty in West Sumatra Province due to the Village Fund allocation percentage being more prominent for village government operations. The allocation of Village Funds for the administration of village government is much larger than what is mandated by law, which is 30%. The main objective of the Village Fund Program is to eradicate poverty and reduce inequality. To achieve this noble goal, it is necessary to evaluate the distribution of Village Funds. This study looks at the effectiveness of the Village Fund in reducing poverty, and looks at the spatial diversity of the effectiveness of the Village Fund in beneficiary regencies/municipals.
Existence and nonexistence of nontrivial solutions for the Schrödinger-Poisson system with zero mass potential
Authors: Wang Xiaoping , Chen Fulai , Liao Fangfang
Published: September 2023

In this article, under some weaker assumptions on

a
>
0

a\gt 0

and

f

f

, the authors aim to study the existence of nontrivial radial solutions and nonexistence of nontrivial solutions for the following Schrödinger-Poisson system with zero mass potential

−
Δ
u
+
ϕ
u
=
−
a

∣
u
∣

p
−
2

u
+
f

(

u

)

,

x
∈

R

3

,

−
Δ
ϕ
=

u

2

,

x
∈

R

3

,

\left\{\begin{array}{ll}-\Delta u+\phi u=-a{| u| }^{p-2}u+f\left(u),& x\in {{\mathbb{R}}}^{3},\\ -\Delta \phi ={u}^{2},& x\in {{\mathbb{R}}}^{3},\end{array}\right.

where

p
∈

2
,

12

5

p\in \left(2,\frac{12}{5}\right)

. In particular, as a corollary for the following system:

−
Δ
u
+
ϕ
u
=
−

∣
u
∣

p
−
2

u
+

∣
u
∣

q
−
2

u
,

x
∈

R

3

,

−
Δ
ϕ
=

u

2

,

x
∈

R

3

,

\left\{\begin{array}{ll}-\Delta u+\phi u=-{| u| }^{p-2}u+{| u| }^{q-2}u,& x\in {{\mathbb{R}}}^{3},\\ -\Delta \phi ={u}^{2},& x\in {{\mathbb{R}}}^{3},\end{array}\right.

a sufficient and necessary condition is obtained on the existence of nontrivial radial solutions.
Unveiling Brand Convergence in Consideration Sets: The Effects of Purchase for Self or Others and Product Nature
Authors: Kikuchi Fumiaki
Published: September 2023

The creation of a consideration set, which constitutes a cluster of brands that a consumer contemplates buying from, plays a vital role in purchasing behavior. An understanding of its composition aids in the development of effective marketing strategies. However, existing research does not sufficiently explore brand convergence in the consideration set across consumers (BCCS). This study explored variations in BCCS according to whether the purchase is intended for self-use or as a gift, as well as the nature of the product (utilitarian or hedonic). A questionnaire survey involving 1219 participants provided data for empirical analysis. The findings revealed a higher BCCS for purchases made for self with respect to utilitarian products such as ballpoint pens, whereas hedonic products such as chocolates showed a higher BCCS when purchased for others than for self. These findings offer new insights into the underexplored area of BCCS; they suggest that desired assortment size should be tailored according to purchase intent and the nature of the targeted product (utilitarian or hedonic).
Diminutive formation in Brazilian Portuguese: a survey
Authors: Newell Cristina , Ellingson Eddington David
Published: September 2023

In a survey, 1,053 Brazilians provided the diminutive form of 60 test words. For example, given desconto participants provided diminutives such as descontinho or descontito. Most responses involved the suffixes -zinho and -inho. However, in many cases -zito and -ito were given as well. Statistical analysis revealed that the final phone and stress pattern of the base word were the most important predictors of diminutive form. A number of age-apparent changes were observed suggesting that certain diminutive forms may be on their way out in words with a particular phonological shape or in certain states. The state of residence, often in interaction with another predictor, proved to be an influencing factor as well. However, similar diminutivization patterns did not hold between geographically contiguous states, but between states with similarly sized populations suggesting an urban versus rural divide in Brazil.
Deletion as novel variants in VPS13B gene in Cohen syndrome: Case series
Authors: Kang Li , Ma Yixuan , Zhao Peng
Published: September 2023

Background

Cohen syndrome (OMIM No. # 216550) is a rare autosomal recessive disorder caused by homozygous mutation in the vacuolar protein sorting 13 homolog B (VPS13B) gene on chromosome 8q22.2. Clinical manifestations include hypermobile joints, microcephaly, intellectual disabilities, craniofacial and limb anomalies, and neutropenia. To date, more than 200 mutations of VPS13B have been reported in over 1,000 Cohen syndrome patients. This article reviews the clinical data of two cases of Cohen syndrome diagnosed by whole exome sequencing.

Results

Both children visited for psychomotor retardation. Gene detection showed a mutation in 8q22.2, NM_017890.4 Intron38 c.6940+1G > T and heterozygotic deletion of exon 3-19 of the VPS13B gene (Case 1), and a mutation in 8q22.2, NM_017890.4 Intron38 c.6940+1G > T and 8q22, NM_017890.4 Exon56 c10334_10335del in the VPS13B gene (Case 2). The variation was predicted to be pathogenic by related software, and they have not been reported.

Conclusion

Cohen syndrome should be considered in the differential diagnosis of any child with developmental retardation and neutropenia. The present study increases the mutation spectrum of the VPS13B gene and could be helpful in genetic diagnosis and genetic counseling in Cohen syndrome patients.
SAĞLIKLI HAYVANLARDAN ALINAN SÜT ÖRNEKLERİNDE POTANSİYEL PATOJENLER VE ÇOKLU ANTİBİYOTİK DİRENÇLİLİĞİ: STREPTOCOCCUS SPP. SUŞLARININ DEĞERLENDİRİLMESİ
Authors: SİPAHİ Nisa , ÇELİK DOĞAN Cansu
Published: September 2023

Çiğ sütün içerdiği mikroorganizma çeşitliliği ve bunların direnç profili potansiyel olarak insan sağlığı ve gıda endüstrisi için bir tehlike arz etmektedir. Bu çalışmada sağlıklı hayvanlardan elde edilen süt örneklerinin patojen ihtivası yönünden incelenmesi, sütün yaygın kontaminantı Streptococcus spp. prevalansının ve antibiyotik direnç profillerinin araştırılması amaçlanmıştır. 249 süt örneğinden Staphylococcus spp., Streptococcus spp., Lactococcus spp., Escherichia coli, Klebsiella oxytoca, Enterecoccus faecalis ve Macrococcus caseolyticus olmak üzere 358 izolat elde edilmiştir. Streptokok prevalansı %24.58 olarak tespit edilmiştir. Streptokok izolatlarının en fazla aminoglikozid sınıfına dirençli olduğu, ardından sırasıyla kinolon, tetrasiklin, makrolid, beta laktam, nitrofuran ve fenikole karşı direnç gösterdiği tespit edilmiştir. Bu durum çiğ süt tüketiminin gıda kaynaklı enfeksiyon için potansiyel bir risk olabileceğini göstermiştir. Bu nedenle tüketicilerin pastörize edilmemiş süt ve süt ürünlerinden kaçınması, çiğ sütlerin antibiyotik direnci yönünden daha fazla izlenmesi ve gerekli önlemlerin alınması gerektiği düşünülmüştür.
THE USE OF REFRACTANCE WINDOW-DRIED EGG POWDER IN CAKE PRODUCTION
Authors: AKDAĞ Zeynep Tuğçe , ÇATALYILDIZ Zeynep Elif , ÇETİN BABAOĞLU Hümeyra , ARSLAN TONTUL Sultan
Published: September 2023

The study aimed to evaluate the use of refractance window-dried egg powders in cake production. It was found that liquid egg white (WL) resulted in the lowest batter density of 1.05 g/mL, followed by egg white powder (WP) at 1.16 g/mL. The highest specific volume was determined in WL samples at 2.71 ml/g, followed by WP samples at 2.46 mL/g. In addition, the use of powdered eggs reduced baking loss but also caused a decrease in the crumb lightness value. Furthermore, the usage of WP had a positive effect on the hardness value of cake samples, which decreased from 884.01 g to 720.53 g. Finally, the alternative use of egg powder had a positive effect on crumb appearance, increasing both cell count and total cell area. Therefore, the incorporation of powdered eggs by refractance window drying instead of liquid eggs in cake production can be considered an applicable approach due to the various benefits it offers.
Metodika zpracování bakalářských a diplomových prací
Authors: Plíva Zdeněk , Drábková Jindra , Koprnický Jan , Petržílka Leoš
Published: September 2023

This textbook comprises a summary of requirements specified by standards, regulations and notices in effect that apply to writing final reports at the Technical University of Liberec. Its principal purpose is to provide guidance for the students at the Faculty of Mechatronics, Informatics, and Interdisciplinary Studies to writing a bachelor or master thesis. Except the faculty logo, it may be utilized for other parts of the university, too. Besides the formal requirements for each chapter in a final paper, the textbook further overviews basic typographic rules, principles of handling pasted objects as well as a brief description of PDF file operations.
Digitalization and smartization as the main tools for recovery of business economy
Authors:   Odesa Polytechnic State University, Dobrianskа Natalia , Yangulov Elvin ,   Odesa Polytechnic State University
Published: September 2023

The article analyzes the volume of tasks that companies will have to perform during a pandemic in Web 3.0. Trends of business development in the conditions of digitalization and pandemic are revealed. Features and the most effective ways to restore sustainable development of the country and enterprises are analyzed. The basic principles and factors of the most effective government in the current conditions are revealed.
Hypoxia-associated genetic signature in ovarian steroid cell tumor NOS
Authors: Chao Angel , Huang Huei-Jean , Lin Chiao-Yun , Lee Chia-Hwa , Lin Chien-Hsing , Chao An-Shine , Lai Chyong-Huey , Chang Ting-Chang , Wu Kai-Yun , Wu Ren-Chin
Published: September 2023

Steroid cell tumors, not otherwise specified (SCT-NOS), are uncommon ovarian neoplasms accompanied by virilization symptoms due to hyperandrogenism, which are malignant in approximately one-third of the cases. Given the rarity of SCT-NOS, their molecular underpinnings have not yet been studied in depth. In this case series, we performed the first comprehensive analysis of the genetic landscape of this rare ovarian tumor. A detailed clinicopathological description of an index case is also provided. Over a 20-year period, a total of eight patients were seen at our institution. Total nucleic acids (RNA and DNA) were extracted from evaluable formalin-fixed, paraffin-embedded tumor specimens (n = 7) and subjected to TruSight Oncology 500 testing and/or exome sequencing. The results identified pathogenic variants in several hypoxia-related genes – including HIF1A, VHL, SDHB, SRC, IDH2, and FOXO4. As the first comprehensive genetic analysis of SCT-NOS, this study shows that dysregulation in the hypoxia signaling pathway is a key molecular feature of this rare tumor. Clinically, long-term follow-up with periodic measurements of androgen levels should be pursued in all cases since recurrences may occur several years after the initial diagnosis.
A symptom-based algorithm for calcium management after thyroid surgery: a prospective multicenter study
Authors: van Kinschot Caroline M J , Lončar Ivona , van Ginhoven Tessa M , Visser W Edward , Peeters Robin P , van Noord Charlotte , _ _
Published: September 2023

Objective

Evidence-based treatment guidelines for the management of postthyroidectomy hypocalcemia are absent. The aim of this study was to evaluate a newly developed symptom-based treatment algorithm including a protocolized attempt to phase out supplementation.

Methods

In a prospective multicenter study, patients were treated according to the new algorithm and compared to a historical cohort of patients treated with a biochemically based approach. The primary outcome was the proportion of patients receiving calcium and/or alfacalcidol supplementation. Secondary outcomes were calcium-related complications and predictors for supplementation.

Results

One hundred thirty-four patients were included prospectively, and compared to 392 historical patients. The new algorithm significantly reduced the proportion of patients treated with calcium and/or alfacalcidol during the first postoperative year (odds ratio (OR): 0.36 (95% CI: 0.23–0.54), P < 0.001), and persistently at 12 months follow-up (OR: 0.51 (95% CI: 0.28–0.90), P < 0.05). No severe calcium-related complications occurred, even though calcium-related visits to the emergency department and readmissions increased (OR: 11.5 (95% CI: 4.51–29.3), P <0.001) and (OR: 3.46 (95% CI: 1.58–7.57), P < 0.05), respectively. The proportional change in pre- to postoperative parathyroid hormone (PTH) was an independent predictor for supplementation (OR: 1.04 (95% CI: 1.02–1.07), P < 0.05).

Conclusions

Symptom-based management of postthyroidectomy hypocalcemia and a protocolized attempt to phase out supplementation safely reduced the proportion of patients receiving supplementation, although the number of calcium-related hospital visits increased. For the future, we envision a more individualized treatment approach for patients at risk for delayed symptomatic hypocalcemia, including the proportional change in pre- to post- operative PTH.
Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice
Authors: Eszlinger Markus , Stephenson Alexandra , Mirhadi Shideh , Patyra Konrad , Moran Michael F , Khalil Moosa , Kero Jukka , Paschke Ralf
Published: September 2023

Objective

Nonautoimmune hyperthyroidism (NAH) is rare and occurs due to a constitutively activating thyroid stimulating hormone receptor (TSHR) mutation. In contrast to other thyroid nodules, no further evaluation for malignancy is recommended for hot thyroid nodules. In the first model for NAH in mice nearly all homozygous mice had developed papillary thyroid cancer by 12 months of age.

Methods

To further evaluate these mice, whole exome sequencing and phosphoproteome analysis were employed in a further generation of mice to identify any other mutations potentially responsible and to identify the pathways involved in thyroid carcinoma development.

Results

Only three genes (Nrg1, Rrs1, Rasal2) were mutated in all mice examined, none of which were known primary drivers of papillary thyroid cancer development. Wild-type and homozygous TSHR D633H knockin mice showed distinct phosphoproteome profiles with an enrichment of altered phosphosites found in ERK/mitogen-activated protein kinase (MAPK) signaling. Most importantly, phosphosites with known downstream effects included BRAF p.S766, which forms an inhibitory site: a decrease of phosphorylation at this site suggests an increase in MEK/ERK pathway activation. The decreased phosphorylation at BRAF p.S766 would suggest decreased AMP-activated protein kinase (AMPK) signaling, which is supported by the decreased phosphorylation of STIM1 p.S257, a downstream AMPK target.

Conclusion

The modified phosphoproteome profile of the homozygous mice in combination with human literature suggests a potential signaling pathway from constitutive TSHR signaling and cAMP activation to the activation of ERK/MAPK signaling. This is the first time that a specific mechanism has been identified for a possible involvement of TSH signaling in thyroid carcinoma development.
Unnecessary thyroid surgery rate for suspicious nodule in the absence of molecular testing
Authors: Mavromati Maria , Saiji Essia , Demarchi Marco Stefano , Lenoir Vincent , Seipel Amanda , Kuczma Paulina , Jornayvaz François R , Becker Minerva , Fernandez Eugenio , De Vito Claudio , Triponez Frédéric , Leboulleux Sophie
Published: September 2023

Background

Molecular tests for suspicious thyroid nodules decrease rates of unnecessary surgeries but are not widely used due to reimbursement issues. The aim of this study was to assess the rate of unnecessary surgery performed in real-life setting for Bethesda III, IV and V nodules in the absence of molecular testing.

Method

This is a single-center retrospective study of consecutive patients undergoing fine needle aspiration cytology (FNAC) with rapid on-site evaluation between January 2017 and December 2021. Unnecessary surgery was defined as surgery performed because of Bethesda III, IV, or V results in the absence of local compressive symptoms with final benign pathology and as second surgery for completion thyroidectomy.

Results

In the 862 patients (640 females, mean age: 54.2 years), 1010 nodules (median size: 24.4 mm) underwent 1189 FNAC. Nodules were EU-TIRADS 2, 3, 4, and 5 in 3%, 34%, 42%, and 22% of cases, respectively. FNAC was Bethesda I, II, III, IV, V, and VI in 8%, 48%, 17%, 17%, 3%, and 6%, respectively. Surgery was performed in 36% of Bethesda III nodules (benign on pathology: 81%), in 74% of Bethesda IV nodules (benign on pathology: 76%) and in 97% of Bethesda V nodules (benign on pathology: 21%). Surgery was considered unnecessary in 56%, 68%, and 21% of patients with Bethesda III, IV, and V nodules, respectively.

Conclusion

In this real data cohort surgery was unnecessary in more than half of patients with Bethesda III and IV nodules and in 21% of patients with Bethesda V nodules.
PENGEMBANGAN BAHAN AJAR BERBASIS KEMAMPUAN PEMECAHAN MASALAH PADA MATERI KESEBANGUNAN DAN KEKONGRUENAN
Authors: Kurniawati Lia , Musyrifah Eva , Narulita Utari
Published: September 2023

AbstractThis study aims to develop teaching materials based on problem-solving abilities in the materials of similarity and congruence at SMP/MTS. Problem solving ability is the ability to solve mathematical problems that are non-routine or procedural as usual which require deeper thinking in solving them. The teaching materials chosen are in the form of student worksheets (LKS). The trial subjects were taken based on nonprobability sampling techniques, specifically purposive sampling, namely 13 students one of the SMP/MTS level schools in Pamulang. The method used in this research is the ADDIE model development research method (Analysis, Design, Development, Implementation, Evaluation). The results showed that the teaching materials developed fell into the very feasible category with a percentage score of 87.11% according to experts consisting of 3 lecturers in the mathematics education department at UIN Syarif Hidayatullah Jakarta and 5 mathematics teachers from several SMP/MTS. The results of the limited trial for students who obtained a percentage score of 80.92% were categorized as feasible by the students. Keywords: Problem Solving Ability, Similarity and Congruence Materials, ADDIE Development Model. AbstrakPenelitian ini bertujuan untuk mengembangkan bahan ajar berbasis kemampuan pemecahan masalah pada Materi Kesebangunan dan Kekongruenan SMP/MTS. Kemampuan pemecahan masalah adalah kemampuan dalam menyelesaikan permasalahan matematika yang bersifat non-rutin atau tidak sesuai prosedural seperti biasa yang dalam menyelesaikannya memerlukan pemikiran yang lebih mendalam. Bahan ajar yang dipilih berupa Lembar Kerja Siswa (LKS). Subjek penelitian diambil berdasarkan teknik nonprobability sampling, tepatnya purposive sampling yaitu 13 orang siswa kelas IX salah satu sekolah tingkat SMP/MTS di Pamulang. Metode yang digunakan dalam penelitian ini adalah metode penelitian pengembangan model ADDIE (Analysis, Design, Development, Implementation, Evaluation). Hasil penelitian menunjukkan bahwa bahan ajar yang dikembangkan masuk ke dalam kategori sangat layak dengan skor persentase 87,11% menurut para ahli yang terdiri dari 3 orang dosen jurusan pendidikan matematika UIN Syarif Hidayatullah Jakarta dan 5 orang guru matematika yang berasal dari beberapa sekolah tingkat SMP/MTS. Hasil uji coba terbatas kepada siswa memperoleh skor persentase 80,92% dikategorikan layak oleh siswa. Kata kunci: Kemampuan Pemecahan Masalah, Matei Kesebangunan dan Kekongurenan, Model Pengembangan ADDIE.
APPLICATION OF THE TEAM GAMES TOURNAMENT (TGT) MODEL TO IMPROVE BASIC MATHEMATICS LEARNING OUTCOMES FOR CIVIL ENGINEERING STUDENTS
Authors: Pohan Rizky Febriani , Rambe Muhammad Rahman , Arifitriana Wirna
Published: September 2023

The success of students in mastering the subject matter of Basic Mathematics can be seen from the results of learning Basic Mathematics. One of the learning models that can activate students and improve learning outcomes in Basic Mathematics is the Team Games Tournament (TGT) learning model. This study aims to determine the effect of the Team Games Tournament (TGT) learning model on the learning outcomes of Basic Mathematics students of the Civil Engineering Study Program and to prove that the Team Games Tournament (TGT) learning model is able to improve learning outcomes of Basic Mathematics students of the Civil Engineering Study Program. This research was conducted through Classroom Action Research (CAR) with a research sample of 40 people. The design used in this study was a pretest-posttest control group design. Based on the research results obtained, it can be concluded that the results of the t-test hypothesis test indicate that tcount ≥ ttable or 14.6551≥ 2.023. This means that Ho is rejected or Ha is accepted. So that the Team Games Tournament (TGT) learning model affects the learning outcomes of Basic Mathematics students of the Civil Engineering Study Program, Universitas Graha Nusantara Padangsidimpuan. Through the application of the Team Games Tournament (TGT) learning model, it is proven that the learning outcomes of Basic Mathematics students of the Civil Engineering Study Program at Graha Nusantara University Padangsidimpuan increased by 48.75% with a percentage effectiveness of 7.14%.
The prognostic significance of the activities of matrix metalloproteinases-2 and -9 in dogs for mammary gland neoplasia (pilot study)
Authors: Kovalenko M. S. , Bilyi D. D. , Hrebeniuk K. R.
Published: September 2023

The aim of this study was to determine the activity of matrix metalloproteinase-2 and -9 in blood and tumour tissue of female dogs with benign and malignant mammary gland neoplasias. The increased activity of matrix metalloproteinase-2 and -9 was registered in 3.8–8.9% of canines with benign neoplasias (adenoma, mixed tumour) and in 32.5–63.5% of those with malignant neoplasias (carcinoma: mixed type, ductal, tubular, tubulopapillary). Neoplastic transformation is accompanied by blood level increase of both latent and active enzyme forms. The dogs with malignant mammary gland neoplasias were diagnosed with credible increase of matrix metalloproteinases-2 activity up to 1.59–1.96 in blood plasma and up to 21.57–24.84 in tumour tissue and the increase of matrix metalloproteinases-9 activity up to 2.16–2.67 and 29.53–35.26 respectively. For benign mammary neoplasms, the proportion of dogs with enhanced expression of matrix metalloproteinase-2 was higher than the number of patients in whom an increase in the level of matrix metalloproteinase-9 or both of these enzymes was registered by 1.7 times, for dogs with malignant tumours – in blood plasma – by 1.4–1.6 times, dogs with neoplastic changed functional tissue – 1.7 and 1.9 times, respectively. Histological type and metastatic foci presence did not correlate with enzymes’ activity. The enzymes’ activity figures in benign neoplasias fluctuated within those in clinically healthy animals. A positive characteristic of determining the plasma and tissue expression level of matrix metalloproteinases in dogs with mammary tumours is the low degree of invasiveness of the method against the background of the high informativeness of the results obtained in the preoperative period. The obtained results prove the possibility of using matrix metalloproteinases-2 and -9 to predict the course and to control the treatment of mammary neoplasia.
Lipid composition of blood plasma and epithelium of the jejunal mucosa in calves with dyspepsia and its correction
Authors: Gryshchenko V. A. , Danchenko O. О. , Tkachuk S. A. , Fotina T. I. , Zazharskyi V. V. , Brygadyrenko V. V.
Published: September 2023

Enteropathology in newborn ruminants significantly affects the functional formation of the digestive tract, which induces complications in other organs and systems, reducing the resistance and productivity in recovered animals. It is also characterized by metabolic disorders, particularly lipids, which adversely affects the regenerative processes at the cellular level. The material for the study was 2-day-old calves, from which 3 groups of 6 animals each were formed. 1st group – control was made up of clinically healthy animals, 2nd group – calves with toxic dyspepsia which received traditional treatment and 3rd group – calves which were additionally orally administered a liposomal form of a 1% solution of BAD "FLP-MD". The lipid composition of blood plasma and the epithelium of the mucous membrane of the jejunum of calves was studied by the method of thin-layer chromatography on standard Silufol plates. The lipidogram of blood plasma in 30-day-old calves recovered from dyspepsia under traditional treatment regimen was characterized by dyslipidemia, which was manifested by an increase in total lipid content by 10.0% amid hypercholesterolemia and hypertriacylglycerolemia and a decrease in free fatty acids by 24.6% and phospholipids by 11.8%. Also, phosphatidylcholine and sphingomyelin content decreasesd in the blood plasma. In epithelium of the jejunal mucosa, total lipid content decreased due to total cholesterol, triacylglycerols, and phospholipids. The restoration of total lipid content and individual fractions was found in blood plasma of calves that received additionally phospholipid-containing bio-additive "FLP-MD". Among the individual phospholipids phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine prevailed. In these calves, most of the lipid components in the epithelium of the jejunal mucosa were stabilized. In the future, we plan to investigate the content of total lipids in the blood and mucous membrane of the small intestine of calves.
Abordaje pedagógico de la diversidad cultural en territorios indígenas de Costa Rica. Una experiencia de actualización profesional docente
Authors: Morales Trejos Carol , Jiménez Espinoza Ericka , Deliyore Vega María del Rocío
Published: September 2023

Este artículo científico aborda el tema de la pedagogía intercultural en territorio indígena, específicamente en el Cantón de Talamanca, Costa Rica. Los hallazgos forman parte del proyecto de acción social ED- 3430 Facilitando oportunidades de aprendizaje con pertinencia cultual en territorios indígenas, cuyo objetivo general consistió en favorecer la actualización profesional de las personas docentes de instituciones de educación formal en territorios indígenas, mediante un curso de actualización con pertinencia cultural al emplear la reflexión-acción. Como metodología, se realiza un estudio bajo el paradigma cualitativo, el tipo de acercamiento empleado fue la investigación-acción, para otorgar protagonismo al profesorado participante, conformado por 17 personas educadoras. Para la recolección de datos se realizó una fase diagnóstica con las técnicas de observación de campo, encuesta y grupo focal; dicho proceso permitió la elaboración del curso de actualización. Posteriormente, en equipos de trabajo, el profesorado diseñó y ejecutó un proyecto denominado “manos a la obra”, se realizaron informes finales que se sistematizaron para la construcción de este artículo. Dentro de los hallazgos, se sitúa el aporte de la Educación Intercultural en la construcción de nuevas prácticas pedagógicas que enriquecen la relación docente-estudiante, se reconoce la importancia de la actualización docente para el abordaje pedagógico de la diversidad cultural, en tanto representa un reto en la formación inicial docente. Como conclusión, pensar la educación nos debe mover a generar espacios efectivos de reflexión-acción educativa, así como a acompañar a los diferentes actores educativos desde una co-construcción intercultural de la teoría y la práctica, configurando nuevos espacios de pensar y de interactuar.
Time effect of dupilumab to treat severe uncontrolled asthma in adolescents
Authors: Indolfi Cristiana , Dinardo Giulio , Klain Angela , Contieri Marcella , Umano Giuseppina Rosaria , Decimo Alberto , Ciprandi Giorgio , Miraglia del Giudice Michele
Published: September 2023

Background: Dupilumab is a new biological drug approved for the treatment of type 2 inflammatory diseases, such as asthma. Dupilumab is a fully humanized monoclonal antibody that acts against both interleukin-4 and interleukin-13 receptors. This study evaluated the time-dependent effect of dupilumab on asthma exacerbations and quality of life in adolescents with uncontrolled severe asthma.
Materials and Methods: Five adolescents suffering from uncontrolled severe asthma and treated with dupilumab were recruited. All subjects were evaluated for 4, 12, and 24 weeks after the first dose of dupilumab. Outcome measures included lung function, fractional exhaled nitric oxide, asthma control and quality of life assessed by validated questionnaires (Asthma Control Test and Asthma Control Questionnaire).
Results: The quality of life improved quickly after 4 weeks of treatment and 80% of adolescents halved the dose of inhaled corticosteroids necessary to control asthma symptoms. These results were still maintained for 24 weeks after start of the therapy. None of the patients had any asthma exacerbation during the study period.
Conclusion: Results of this study demonstrated that dupilumab was quickly effective to reduce asthma exacerbation and ameliorate quality of life in severe asthmatic adolescents.