bluuebunny/crossref_metadata_2025 huggingface dataset:
A preliminary survey on the occurrence of barbering in laboratory mice in Germany
Authors: Kahnau P , Jaap A , Hobbiesiefken U , Mieske P , Diederich K , Thöne-Reineke C , Lewejohann L , Hohlbaum K
Published: October 2022

Although barbering is common in laboratory mice (Mus musculus), little is known about its effects, both on animal welfare and the research data collected from barbered mice. To gain information on the occurrence of barbering and related risk factors in animal facilities in Germany, we performed an online survey. All the respondents (n = 32 animal facilities) had experienced barbering in their facility. In most cases, less than 10% of the mice were affected, and the age of onset was mostly observed to be 2 to < 6 months. A greater susceptibility was reported in females and in C57BL/6 mice, but this could not be verified as the prevalence of females and the C57BL/6 strain was unknown. One facility reported differences in barbering between commercial animal suppliers. Barbering was also recorded in mice provided with enrichments, such as houses, wood-gnawing blocks, tunnels, running wheels/discs or cage dividers. None of the responding facilities provided swings, structural elements such as an elevated platform or foraging and cognitive enrichment. The questions of whether barbering may have an impact on study results and whether victims of barbering can be used for experiments revealed mixed opinions, most likely due to a lack of data on potential effects. This survey clearly demonstrated barbering to be a widely underestimated problem that is not given enough attention. We suggest that the occurrence of barbering should be systematically documented in every animal facility and reported in research articles, to provide a greater understanding of barbering and its potential effects.
Using sensors to detect individual responses of lambs during transport and pre-slaughter handling and their relationship with meat quality
Authors: Ogun S , Viola I , Obertino M , Manenti I , Ala U , Brugiapaglia A , Battaglini L , Perona G , Baratta M
Published: October 2022

Rapid analysis of animal welfare is a crucial component of the assessment of the meat quality supply chain, ensuring management procedures confer optimum standards of welfare. Further, there is increasing interest in monitoring the welfare state of each individual animal. This study looked at transport and pre-slaughter management in terms of meat quality evaluated in two breeds (Biellese and Sambucana) across two different farming systems. Precision Livestock Farming (PLF) technologies were implemented, including accelerometer and rumination activity ear-tag sensors, as potential welfare indicators during transportation and pre-slaughter. Significant correlations were found between sensors’ parameters, such as total activity and rumination and physical and chemical meat quality characteristics such as drip loss. Lambs with lower rumination and/or lower total activity were found to have lower drip loss indicating reduced meat quality. Sensors have the potential to help detect those animals particularly sensitive to stressors during transport and pre-slaughter handling and may allow real-time measurement of the impact of transport and handling in abattoirs, enabling better animal management via specific customised strategies.
Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling
Authors: Hwang Woong Y , Kostiuk Valentyna , González Delfina P , Lusk C Patrick , Khokha Mustafa K
Published: October 2022

Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for disease pathogenesis. β-catenin is a key effector in this pathway that translocates into the nucleus and activates Wnt responsive genes. However, due to our lack of understanding of β-catenin nuclear transport, therapeutic modulation of Wnt signaling has been challenging. Here, we took an unconventional approach to address this long-standing question by exploiting a heterologous model system, the budding yeast Saccharomyces cerevisiae, which contains a conserved nuclear transport machinery. In contrast to prior work, we demonstrate that β-catenin accumulates in the nucleus in a Ran-dependent manner, suggesting the use of a nuclear transport receptor (NTR). Indeed, a systematic and conditional inhibition of NTRs revealed that only Kap104, the ortholog of Kap-β2/Transportin-1 (TNPO1), was required for β-catenin nuclear import. We further demonstrate direct binding between TNPO1 and β-catenin that is mediated by a conserved PY-NLS. Finally, using Xenopus secondary axis and TCF/LEF (T Cell factor/lymphoid enhancer factor family) reporter assays, we demonstrate that our results in yeast can be directly translated to vertebrates. By elucidating the nuclear localization signal in β-catenin and its cognate NTR, our study suggests new therapeutic targets for a host of human diseases caused by excessive Wnt signaling. Indeed, we demonstrate that a small chimeric peptide designed to target TNPO1 can reduce Wnt signaling as a first step toward therapeutics.
Diversification dynamics in the Neotropics through time, clades, and biogeographic regions
Authors: Meseguer Andrea S , Michel Alice , Fabre Pierre-Henri , Pérez Escobar Oscar A , Chomicki Guillaume , Riina Ricarda , Antonelli Alexandre , Antoine Pierre-Olivier , Delsuc Frédéric , Condamine Fabien L
Published: October 2022

The origins and evolution of the outstanding Neotropical biodiversity are a matter of intense debate. A comprehensive understanding is hindered by the lack of deep-time comparative data across wide phylogenetic and ecological contexts. Here, we quantify the prevailing diversification trajectories and drivers of Neotropical diversification in a sample of 150 phylogenies (12,512 species) of seed plants and tetrapods, and assess their variation across Neotropical regions and taxa. Analyses indicate that Neotropical diversity has mostly expanded through time (70% of the clades), while scenarios of saturated and declining diversity account for 21% and 9% of Neotropical diversity, respectively. Five biogeographic areas are identified as distinctive units of long-term Neotropical evolution, including Pan-Amazonia, the Dry Diagonal, and Bahama-Antilles. Diversification dynamics do not differ across these areas, suggesting no geographic structure in long-term Neotropical diversification. In contrast, diversification dynamics differ across taxa: plant diversity mostly expanded through time (88%), while a substantial fraction (43%) of tetrapod diversity accumulated at a slower pace or declined towards the present. These opposite evolutionary patterns may reflect different capacities for plants and tetrapods to cope with past climate changes.
Wide-ranging consequences of priority effects governed by an overarching factor
Authors: Chappell Callie R , Dhami Manpreet K , Bitter Mark C , Czech Lucas , Herrera Paredes Sur , Barrie Fatoumata Binta , Calderón Yadira , Eritano Katherine , Golden Lexi-Ann , Hekmat-Scafe Daria , Hsu Veronica , Kieschnick Clara , Malladi Shyamala , Rush Nicole , Fukami Tadashi
Published: October 2022

Priority effects, where arrival order and initial relative abundance modulate local species interactions, can exert taxonomic, functional, and evolutionary influences on ecological communities by driving them to alternative states. It remains unclear if these wide-ranging consequences of priority effects can be explained systematically by a common underlying factor. Here, we identify such a factor in an empirical system. In a series of field and laboratory studies, we focus on how pH affects nectar-colonizing microbes and their interactions with plants and pollinators. In a field survey, we found that nectar microbial communities in a hummingbird-pollinated shrub, Diplacus (formerly Mimulus) aurantiacus, exhibited abundance patterns indicative of alternative stable states that emerge through domination by either bacteria or yeasts within individual flowers. In addition, nectar pH varied among D. aurantiacus flowers in a manner that is consistent with the existence of these alternative stable states. In laboratory experiments, Acinetobacter nectaris, the bacterium most commonly found in D. aurantiacus nectar, exerted a strongly negative priority effect against Metschnikowia reukaufii, the most common nectar-specialist yeast, by reducing nectar pH. This priority effect likely explains the mutually exclusive pattern of dominance found in the field survey. Furthermore, experimental evolution simulating hummingbird-assisted dispersal between flowers revealed that M. reukaufii could evolve rapidly to improve resistance against the priority effect if constantly exposed to A. nectaris-induced pH reduction. Finally, in a field experiment, we found that low nectar pH could reduce nectar consumption by hummingbirds, suggesting functional consequences of the pH-driven priority effect for plant reproduction. Taken together, these results show that it is possible to identify an overarching factor that governs the eco-evolutionary dynamics of priority effects across multiple levels of biological organization.
Genome-wide identification and expression analysis of SBP-box gene family reveal their involvement in hormone response and abiotic stresses in Chrysanthemum nankingense
Authors: Li Ziwei , Yang Yujia , Chen Bin , Xia Bin , Li Hongyao , Zhou Yunwei , He Miao
Published: October 2022

SQUAMOSA promoter-binding-protein (SBP)-box family proteins are a class of plant-specific transcription factors, and widely regulate the development of floral and leaf morphology in plant growth and involve in environment and hormone signal response. In this study, we isolated and identified 21 non-redundant SBP-box genes in Chrysanthemum nankingense with bioinformatics analysis. Sequence alignments of 21 CnSBP proteins discovered a highly conserved SBP domain including two zinc finger-like structures and a nuclear localization signal region. According to the amino acid sequence alignments, 67 SBP-box genes from Arabidopsis thaliana, rice, Artemisia annua and C. nankingense were clustered into eight groups, and the motif and gene structure analysis also sustained this classification. The gene evolution analysis indicated the CnSBP genes experienced a duplication event about 10 million years ago (Mya), and the CnSBP and AtSPL genes occurred a divergence at 24 Mya. Transcriptome data provided valuable information for tissue-specific expression profiles of the CnSBPs, which highly expressed in floral tissues and differentially expressed in leaf, root and stem organs. Quantitative Real-time Polymerase Chain Reaction data showed expression patterns of the CnSBPs under exogenous hormone and abiotic stress treatments, separately abscisic acid, salicylic acid, gibberellin A3, methyl jasmonate and ethylene spraying as well as salt and drought stresses, indicating that the candidate CnSBP genes showed differentiated spatiotemporal expression patterns in response to hormone and abiotic stresses. Our study provides a systematic genome-wide analysis of the SBP-box gene family in C. nankingense. In general, it provides a fundamental theoretical basis that SBP-box genes may regulate the resistance of stress physiology in chrysanthemum via exogenous hormone pathways.
Rediscovery and redescription of the only known mosasaur bone from the Turonian (Upper Cretaceous) of Poland
Authors: Skawiński Tomasz
Published: October 2022

Mosasaur remains from Poland are very rare and are restricted mostly to the Campanian and Maastrichtian. The only currently known pre-Campanian records come from the Turonian strata in the Opole area, southwestern Poland. One of them is a single tooth which probably belongs to a yaguarasaurine while the other is an incomplete vertebra, for many years considered lost. The latter specimen has recently been found and is redescribed in this article. Its most characteristic feature is a strong dorsoventral compression of the articular surfaces. This is similar to the condition observed in basal mosasauroids such as halisaurines and tethysaurines. Unfortunately, due to its incompleteness, the rediscovered specimen cannot be confidently referred to any of these clades and can only be described as a probable non-mosasaurine, non-plioplatecarpine, non-tylosaurine mosasauroid. Despite its uncertain phylogenetic position, it is important from a historical point of view and as only the second record (and the only bone record) of mosasauroids from the Turonian of Poland.
Facade Features of the Houses in the Saray District of Malatya / Battalgazi
Authors: YARİŞ Sahure
Published: October 2022

Yontma Taş çağından itibaren varlığı bilinen ev; insanların fizyolojik, sosyolojik ve ekonomik ihtiyaçlarının karşılandığı bir yaşam alanıdır. Bu yapı biriminin oluşmasında ekonomik, toplumsal, kültürel ve coğrafi özelliklerin etkilidir.
Bölgelerin malzeme, teknik, süsleme özellikleriyle farklılaştığı evlerde genellikle Türk Evi planı kullanılır. Fakat bölgesel ihtiyaçlardan dolayı planda bazı farklılıklar göze çarpar. İhtiyaca göre oda sayısı artar, açık ve kapalı
alanlar değişebilir. Plan, genellikle İslam dininin esasları dikkate alınarak şekillenir. Evler, 19. yüzyıl ve sonrasında Osmanlı Mimarisinde geniş yer tutar. Eski Malatya (Battalgazi) bu evlerin, Cumhuriyet döneminde yeniden şekillendiği
bir merkezdir. Doğu Anadolu Bölgesi’nin önemli kavşak noktalarından biri olan Malatya, ilk olarak Hititler döneminde Meldia (Meyve bahçesi) ismiyle Aslantepe Höyüğünde kurulmuştur. İpek yolu üzerinde kurulan şehir, ticaret açısından
önemli stratejik bir noktada olduğu için tarih boyunca birçok medeniyete, kültüre ev sahipliği yapmıştır. Son olarak 1515 yılında Osmanlı Devleti hâkimiyetine geçen şehir, bir Türk şehri kalmaya devam etmiştir. 1840 yılına kadar
Eski Malatya (Battalgazi), şehir merkezi konumunu korumuştur. Türk-İslam eserlerinin ilk örneklerinin merkezi olan Battalgazi’de sivil mimari eserlerin en güzel örnekleri olan evler. Cumhuriyet dönemiyle birlikte yenilenmiş ve
geleneksel özelliklerini koruyarak günümüze kadar gelebilmiştir. Makalede Malatya’nın Battalgazi İlçesi Saray Mahallesi’nde bulunan altı evin cephe özellikleri değerlendirilmeye çalışılmıştır. Cepheler; Türk Evinin genel özelliği
olan süslemeden uzak, sade cephe olmasının yanı sıra karakteristik olarak belirli bir düzen içerisinde sokağa yansımıştır. Bu evler; Ayten Taner – Hacer Nurten Burnaka Evi, Bekir Sıtkı Arpacı Evi, Emine Turfanda Evi, Mahir Aydoğan
ve Müşterekleri Evi, Müşerref Arpacı Evi, Hatice ve Perihan Arpacı Evi. Evler zemin ve birinci kattan oluşmaktadır. Zemin kattın cephesinde pencereler ve eve giriş kapısı yer alır. Giriş kapıları bazı evlerde sokaktan doğrudan
yaşam alanlarına açılırken bazı evlerde bahçeye açılmaktadır. Cephedeki pencereler, dikdörtgen formlu ve genellikle küçük boyuttadır. Evin birinci katında pencere sayısı artmıştır. Evlerin cephe özellikleri bakımından karakteristik
olan çıkma (cumba) yer alır. Büyük olan evlerin orta kısmında, küçük olan evlerin ise cephenin bir bölümünde ileri doğru uzatılan çıkmalar, genellikle odanın genişliğine göre yapılır ve ahşap malzeme ile vurgulanır. Orta bölümün
ya her iki yanında ya da bir tarafında yapılmış, dışa pencerelerle açılan yaşam alanları yer alır. Dikdörtgen formdaki pencereleri çevreleyen, iç içe birkaç silmeden oluşmuş yuvarlak kemer dizileri yer alır. Evler, ileri doğru
uzayan geniş saçak ve üst örtü olarak genellikle kırma veya beşik çatı kullanılarak tamamlanmıştır.
Analysis of the Broadcasting History Museum of Turkish Radio and Television Corporation (TRT) From The Perspective of Visual Communication Design
Authors: MAZLUM Özge , TURHANGİL Sıla ARICI
Published: October 2022

Günümüzde müzelerin koleksiyon ve bilgi sunmasının yanında, izleyicilerle aktif olarak ilgilenmesi ve hedeflerine ulaşmak için farklı yöntemler geliştirmesi beklenmektedir. Müzecilikte ziyaretçilerin beklenti ve alışkanlıkları dikkate
alındığında son yıllarda sanal ortam uygulamalarında bir artış görülmektedir. Bu değişim sonucunda müzelerin, kimlik, işlev ve konumlandırmasını tekrar tasarlaması gerekmektedir. “Yeni müzecilik” anlayışı, kültür, iletişim ve eğitim
arasındaki ilişkiyi farklı bir şekilde ele almaktadır. Çağdaş müze, ziyaretçi bekleyen değil, modern iletişim yöntemleri ile müzeyi insanların ayağına götüren, sergileme, tanıtım, eğitim gibi işlevlerini gerçekleştirmek için ziyaretçisinin
dikkatini çekecek stratejiler geliştiren bir anlayışa sahiptir. Çağdaş müzecilik anlayışına göre “iletişim”, müzeler için tamamlayıcı bir alt yapı unsurudur. Çağdaş müzecilikte, müzeler sahip oldukları koleksiyonları, özel sergileri
ve tanıtımlarını modern iletişim araçlarıyla izleyicisine sunmaktadır. TRT Yayıncılık Tarihi Müzesi; hem yayıncılıkta teknolojinin zaman içerisindeki değişim ve gelişiminin yansıtılması hem de etkileşimli bir iletişim müze olması
açısından örnek oluşturacak niteliktedir. Bu araştırma, var olan durumu belirlemeye yönelik olduğundan “betimsel tarama” modelindedir. Bu araştırmada; dijital teknolojilerin yarattığı değişim ile ortaya çıkan yeni müzecilik anlayışı
ile TRT Yayıncılık Tarihi Müzesi, görsel iletişim tasarımı uygulamaları açısından ele alınmıştır. Araştırma kapsamında, TRT Müzesi “rehber” eşliğinde ziyaret edilmiş, ayrıca kavramsal çerçevede elde edilen değerlendirme kriterleri
kapsamında değerlendirilerek veriler elde edilmiştir. Araştırmanın sonucunda; TRT Müzesi iletişim tasarımının yeniden planlanması gerektiği görülmüş ve öneriler sunulmuştur. Çağdaş müzecilik anlayışı ile TRT Müzesi’nin değerlendirildiği
bu araştırmanın özgünlüğüyle literatüre katkı sağlayacağı ve müzelere iletişim noktasında yol göstereceği düşünülmektedir.
Bibliometric Analysis of Researches That Contains “Art and Design” Keywords
Authors: GEÇİMLİ Meryem , KÖKSAL Kemal
Published: October 2022

Bibliyometrik analiz, belirli bir alan veya tarihsel süreç içerisinde yapılmış akademik çalışmaların sayısal olarak analiz edilmesidir. Bu araştırmanın amacı sanat ve tasarım alanında yapılmış yayınların bibliyometrik analizini yapmaktır.
Çalışma kapsamında Web of Science (WOS) veritabanında yer alan Social Science Citiation Index (SSCI)’te taranan yayınlarda “art and design” kelimeleri taratılarak bulunan toplam 9285 yayın bibliyometrik analiz kapsamında incelenmiştir.
1975 yılından günümüze tüm yayınlar, gelecek sayılar için erken gösterimler de dahil olmak üzere değerlendirme kapsamına alınmıştır. Sanat ve tasarım kelimleri ile ilgili bu konuda kapsamlı bir çalışma bulunmamaktadır. Çalışma
sürecinde veri büyüklüğü sebebiyle tarihsel gruplandırma yapılmıştır. Çalışmanın özgün değeri “art and design” kelimeleri ile WOS veri tabanında kayıtlı geniş zaman diliminin incelenmiş olmasıdır. Çalışmanın sonucunda içerisinde
“sanat ve tasarım” kelimeleri geçen yayınlar kapsamında 2005 yılına kadar yılda 100 yayın altında çalışma bulunmaktadır. 2021 yılında ise bu sayı 1000 üzerine çıkmıştır. Bunun yanı sıra yıllara göre artan biçimde dil çeşitliliği
de bulunmaktadır. En fazla atıf alan yazarların idari bilimler alanında çalışmaları bulunmaktadır. En çok yayın yapılan dergi ise sanat ve yaratıcı eğitim üzerinedir. Son olarak en çok yayın çıkaran yayımcıların disiplinlerararası
özellikte olduğu görülmektedir. Bu araştırmada anket, mülakat, odak grup görüşmesi vb. şekilde katılımcılardan veri elde edilmediği için Etik Kurul İzin Belgesine ihtiyaç yoktur.
The Presentation of Sexuality in Cartoons in the Context of Freud's Dream Theory: A Semiotic Analysis of "3Below: Tales of Arcadia"
Authors: ÇAMUR Mutluhan
Published: October 2022

Çizgi filmlerin hedef kitlesi genelde çocuklardır. Dolayısıyla çocukların beğenerek izlediği bu yapımlar onların sosyalleşmesi ve bilinçlenmesi açısından oldukça önemli bir işleve sahiptir. Çocukluk dönemi, etkiye en açık olunan dönemdir.
Bu dönemde bilinçaltının şekillenmesinde çizgi filmlerin etkisi oldukça önemli görülmektedir. Çizgi filmler aracılığıyla çocuklara belli mesajların aktarılması söz konusudur. Çizgi filmlerde adalet, sevgi, eşitlik vb. olumlu mesajlar
iletildiği gibi şiddet, cinsellik vb. olumsuz mesajlar da aktarılmaktadır. Bu mesajlar, çocukların özdeşim kurduğu karakterler aracılığıyla benimsenmektedir. Medyanın etkisine açık olan çocukların, çizgi filmler aracılığıyla bilinçaltına
olumsuz göstergeler ekilmesi ciddi bir sorun olarak görülmektedir. Çizgi filmin arkeolojik çerçevesi ve iletişimsel işlevleri üzerinde durulan çalışmada Freud’un “Rüya Kuramı” detaylandırılmaktadır. Bu bağlamda çizgi filmlerde
cinselliğin örtük bir şekilde, semboller aracılığıyla nasıl sunulduğu konusuna odaklanılmaktadır. Bu yönüyle çalışma, çizgi filmlerde semboller aracılığıyla örtük bir biçimde sunulan cinsel öğelerin ortaya çıkarılmasını amaçlamaktadır.
Bu amaç doğrultusunda, Türk medyasında sıkça tartışılan, IMBD puanı yüksek ve yapılan ön incelemede oldukça fazla cinsel öğe barındırdığı tespit edilen Netflix yapımı “3 Altında: Arcadia Hikâyeleri” filmi örneklem olarak ele alınmaktadır.
Filmin, Sigmund Freud’un “Rüya Kuramı”ndan hareketle göstergebilimsel analizi yapılmaktadır. Yapılan incelemede, analiz edilen çizgi filmde cinselliğin genel itibariyle örtük bir şekilde, semboller aracılığıyla sunulduğu ve çocuk
bedenlerinin cinsel arzu nesnesi olarak kullanıldığı görülmektedir.
A Theoretical Perspective on the Denouement of the Family Through the Individual-Society Dichotomy
Authors: YILDIRIM İrfan
Published: October 2022

Aralarında dikotomik bir ilişki bulunan birey ve toplum kavramlarının her biri, tarihsel olarak bazı dönemlerde belirgin şekilde öne çıkmıştır. Özellikle geleneksel tarım toplumlarında veya dinsel değerlerin baskın olduğu yerlerde
‘toplumcu’ bir anlayış ön planda iken modern toplumlarda bireyin konumu toplumsal olanın önüne geçmiştir. Modernleşme ile yaşanan değişim sürecinin vitrini ise aile kurumu olmuş ve aile birçok yönden dönüşüme uğramıştır. Bu çalışmada,
son yüzyıllarda önemli ölçüde değişim ve dönüşüme uğrayan ailenin birey-toplum ilişkisi üzerinden konumunun, ailede yaşanan yapısal ve işlevsel değişimlerin ve bu değişimler üzerinde etkili faktörlerin incelenmesi amaçlanmıştır.
Bu bağlamda çalışmada birey ve toplum kavramları, modernleşme süreciyle birlikte ailede yaşanan yapısal ve işlevsel değişimler, ailenin geleceğini tehdit eden olası risk faktörleri incelenmiş ve ailenin geleceğinin genel bir değerlendirilmesi
yapılmıştır. Materyal olarak, aile kurumu ile ilgili yerli ve yabancı literatürden yararlanılmış, yöntemde ise söz konusu kaynakların yorumlanması ve sentezlenmesi ile ailenin yakın geçmişteki seyrinin incelenmesi ve günümüzde
aile kurumunun içinde bulunduğu koşulların gelecekte hangi yöne doğru evirileceğinin sosyolojik boyuttan bir değerlendirilmesi esas alınmıştır. Çalışmanın ulaştığı sonuç ise dikotomik ilişkiye sahip birey ve toplum kavramlarının
modernleşme ile müphemleştiği, değerlerden arınmış aile modelinin günümüzde giderek belirginleştiği, bireyciliğin fazlasıyla öne çıkarıldığı ve bununla bağlantılı diğer bazı gelişmelerin ailenin geleceğini tehdit ettiği yönündedir.
Turkey As A Muslim-Friendly Destination: HalalBooking.Com Foreign Customer Reviews (2017-2021)
Authors: KUNT Sinem
Published: October 2022

Müslüman seyahat pazarındaki artan rakamlar, seyahat endüstrisinin önemli bir bölümü olarak kabul edilmektedir. Müslüman dostu nitelikler sağlayan Müslüman dostu bir destinasyona seyahat etme talebi önemli ölçüde artmıştır. Müslüman-Dostu
nitelikler sağlayan Türkiye de bu pazardan pay alan ve seyahat talebi olan ülkeler arasındadır. Çalışmanın amacı Müslüman-dostu bir destinasyon olarak Türkiye’yi tercih eden yabancı turistlerin gözünden tatil deneyimlerini ortaya
koymaktır. Bu amaç doğrultusunda CrescentRating kuruluşunun, Müslüman ziyaretçiler için inanç temelli belirlediği altı kriteri dikkate alınarak amaçlı örneklem yöntemi kullanılmıştır. Bu sayede “Türkiye’de son beş yıla ait 2017-2021
yılları arasında HalalBooking.com web sitesi aracılığıyla rezervasyonlarını yapmış ve Müslüman-dostu konaklama işletmelerinde konaklamış ve aynı sitede yorum paylaşmış 7,819 yabancı müşteri yorumu” analiz edilmiştir. Araştırmada
nitel veri toplama yöntemi kullanılmıştır. Araştırma, Olgu Bilim desenine dayanmaktadır. Çalışmada nitel analiz programı Nvivo 12 Plus sürümü kullanılmıştır. Yapılan kodlama, kelime grubu ve kelime sıklığı içerik analizleri sonucunda
Müslüman-dostu konaklama işletmelerine ait 12 tema ortaya çıkmıştır. Bu temalar sırası ile temizlik, rahatlık, oda olanakları, yiyecek ve içecekler, personel, fiyat ve fayda dengesi, konum, wi-fi, bayanlar için hizmetler (havuz,
spa, plaj, vs.), çocuklar için hizmetler (havuz, oyunlar, vs.), aile ortamı (rahatlık, eğlence, vs.) ve genel helal özellikli olma durumu olarak belirtilmektedir. Bunun yanı sıra Müşteri yorumlarında en fazla kullanılan ilk üç
kelimenin personel (2,676), harika (1,821) ve mükemmel (1,228) kelimeleri bulunmuştur. Çalışmadaki kelimelerin otel olanakları (cami, plaj, deniz, sauna, spa, hamam, havuz, personel, restoran, temizlik, eğlence, yiyecek ve içecek
hizmetleri) ile bağlantılı olduğu anlaşılmış ve yabancı turistlerin Türkiye’deki Müslüman-dostu otel deneyimlerinin olumlu görüntü çizdiği sonucuna varılmıştır.
Factors Affecting Graft Uptake of Large Wound Surface, Covered by Mesh Split Skin Grafting: A Longitudinal Study
Authors: Rawat Rajneesh , Lanjewar Sunil M , Chauhan Rohit Kumar , Baghel Jyoti
Published: October 2022

Introduction: Skin grafting is one of the most indispensable techniques in surgery these days. In low resource settings, skin grafting using mesh, still forms the important technique of wound coverage. Aim: To evaluate the factors affecting graft uptake of large wound surface, covered by mesh split skin grafting on various postoperative days (day 5, day 10 and day 21). Materials and Methods: This prospective longitudinal study was conducted at Indira Gandhi Government Medical College and Hospital, Nagpur, Maharashtra, India, from June 2017 to December 2019, among patients with large wound surface. After baseline evaluation and wound preparation; patients were posted for mesh skin grafting. Postoperatively, the graft uptake percentage was assessed on the day 5, day 10 and day 21. Other parameters that were assessed were demographic details, mean stay of the patients during the preoperative and postoperative period, effect of various factors (age, gender, co-morbidities, addictions, site and aetiology of raw area, preoperative cultures) influencing graft uptake and postoperative complications. Statistical Package for Social Sciences (SPSS) version 20.0 was used for statistical analysis. Results: A total of 117 patients were enrolled in the study, out of which, 97 (82.9%) of the patients were males. The most common raw area was seen in lower limbs and accounted for 98 patients (79.1%) and the most common cause of raw area was cellulitis (n=91). Out of 117 patients, 105 (89.7%) had successful graft uptake on postoperative day 5, 102 patients (87.2%) on day 10 and 100 patients (85.4%) on day 21. Whereas, 17 (14.5%) patients had failed uptake of graft on postoperative day 21. It was observed that age (p-value=0.04) and preoperative cultures (p-value=0.01) were statistically significant factors influencing graft uptake. Conclusion: The present study reports mesh split skin grafting, a reliable and useful technique with successful graft uptake. Hence, it can be considered for the management of large raw areas.
Viral Aetiology of Severe Acute Lower Respiratory Tract Infection in Children from the Paediatric Intensive Care Unit at a Tertiary Care Hospital, Eastern India- A Retrospective Study
Authors: Ahuja Neha , Gorain Somenath , Pal Partha Pratim , Das Mousumi
Published: October 2022

Introduction: Viral infections are the common source of lower respiratory tract infection worldwide. Rapid and accurate detection of viral infections is important that can prevent antibiotic abuse. However, there are few studies determining viral etiologies in paediatric subjects in Eastern India. Aim: To study viral aetiology in children hospitalised with severe Acute Lower Respiratory Tract Infection (ALRTI) over a period of two years and to detect the impact of co-infection on severity and duration of hospitalization. Materials and Methods: This was a retrospective study based on electronic database in a tertiary care Paediatric Intensive Care Unit (PICU) of Bhagirathi Neotia Women and Child Care Hospital, Kolkata, West Bengal, India. Data were collected for all the patients who fulfilled the selection criteria and were admitted to PICU with ALRTI from March 2018 to March 2020. The medical records were reviewed in 51 patients with positive viral Reverse Transcription Polymerase Chain Reaction (RT-PCR). Data was collected for the type of viruses infecting the subjects and whether there were single infection or co-infection. Co-infection is simultaneous infection with more than one virus. Statistical analysis was done using the IBM Statistical Package for Social Sciences (SPSS) Statistics for Windows, version 24.0 (Armonk, NY: IBM Corp). Student’s t-test and Chi-square test were used to compare single infection and co-infection. A p-value <0.05 was considered significant assuming the confidence interval of 95% as the level of significance. Results: The highest positivity rate was 66.6% (34/51) observed in children in the age group 1-12 months. The common viruses detected were adenovirus seen in 51% of samples, Respiratory Syncytial Virus (RSV) in 31.3% and rhinovirus in 11.8%. Clustering of cases was observed for RSV and influenza A in the colder months of the year. Single infection was seen in 74.5% of samples and co-infection in 25.5%. Comparison between single and co-infection with two viruses in terms of complications (p-value=0.163), average duration of PICU stay (p-value=0.70), C-reactive protein (p-value=0.952), procalcitonin (p-value=0.198), white blood cell count (p-value=0.737), absolute neutrophil count (p-value=0.612) were not significant. Conclusion: This present study found that adenovirus and RSV were the leading viral pathogens for ALRTI in the PICU. Co-infection with multiple viruses compared with a single viral infection in a patient did not impact severity.
Problems in the Adoption of Climate-Resilient Technologies by the Farmers of Telangana State, India
Authors: Acharitha G. , Savitha B. , Rekha Bhanu , Babu K. K. Madhu
Published: October 2022

Climate change refers to significant changes in global temperature, precipitation, and wind patterns. Climate change hasa serious impact on the natural resources available on the earth. Climate change adversely affects human health and quality of life. A majority of the population depends on agriculture directly or indirectly and it is more vulnerable to climate change. To mitigate the adverse effects of climate change, climate-resilient agriculture has become a boon to the farmers in areas that are vulnerable to climatic effects like drought, floods, etc., National Innovations on Climate Resilient Agriculture (NICRA), is a project launched by the Indian Council of Agricultural Research (ICAR) with the aim to enhance the resilience of Indian agriculture to climate change and climate variability through strategic research and technology demonstrations. Krishi Vigyan Kendras (KVKs) is the main implementing agency of NICRA. With the help of KVKs, the interventions of NICRA were accessible throughout the country. The present study was conducted in the Nalgonda district and Khammam district of Telangana. The ex-post-facto research design was used for the study. A sample of 120 respondents from NICRA implemented villages and 60 farmers from non-NICRA implemented villages were selected randomly for the study. The major problems in the adoption of CRA technologies were limited knowledge of CRA technologies (91.66%) followed by inadequate trainings regarding climate-resilient practices (90.00%),inadequate weather based agro advisory services (88.33%), limited outreach of extension services about climate-resilient technologies to (76.66%), non -availability of required implements in custom hiring centres at the time of heavy demand (73.33%), etc., In case of non-NICRA implemented villages, the major problems faced by the respondents were lack of confidence among the farmers to adopt the new CRA technologies due to the fear of failure (93.33%), lack of awareness on climate-resilient technologies among non-NICRA farmers (90.00%), Difficulty in the understanding of CRA technology (86.67%), adoption of CRA technologies demand more resources like water, labour and money (83.33%), less number of need-based training on CRA technologies (75.00%), lack of access to improved crop varieties and other inputs (70.00%), etc.
Trend Analysis of Rainfall in Telangana State (India) Using Advanced Statistical Approaches
Authors: Bellamkonda Jyostna , Meena Admala , Rathod Santosha , Tuti Mangal Deep , Kallakuri Supriya , Bhanusree D. , Reddy Bojjareddygari Nanda Kumar
Published: October 2022

This study was carried out to analyse the trend analysis of the long-term annual and seasonal rainfall pattern in Telangana state, India. For this study monthly rainfall data of Telangana state from January 1982 to December 2021 was collected from the NASA power website (https://power.Iarc.nasa.gov). The linear regression trend line and the non-parametric tests, such as Mann-Kendall test, Modified-Mann Kendall test and Innovative trend analysis tests, were used to understand the trend present in the rainfall data of Telangana. Wallis and Moore test was used to test the randomness of the rainfall data under consideration. Both increasing and decreasing trend was seen in linear regression trend method for Telangana rainfall data. The significant result was found in the month of May which showed an increasing trend, whereas remaining months showed the non-significant trend in the Modified Mann Kendall test as well as in the Innovative trend analysis. The pre-monsoon, monsoon and post-monsoon periods showed a non-significant trend in the rainfall pattern of Telangana state. The annual rainfall of Telangana showed a non-significant trend pattern by Modified Mann-Kendall test. There was a significant increasing trend of rainfall in the month of May and remaining months showed a non-significant trend and no significant trend in the monsoon periods. These accurate identification of rainfall patterns over the area may help to create the appropriate policy measures in advance to plan the future climate uncertainties.
Land Use Based Distribution Pattern, Fractionation forms and Health Risk Assessment of Heavy Metals in Mining-affected Soils of Western Ghat of Goa, India
Authors: Daripa Amrita , Chattaraj Sudipta , Malav Lal C. , Sharma Ramprasad , Naitam Ravindra K. , Mohekar Deepak S , Ramamurthy V.
Published: October 2022

Goa is a biodiversity hotspot and a major iron ore producer state in India. The study investigated heavy metal (HM) distribution pattern, fractionation forms under different land use types near an iron mining including health risks associated with different exposure pathways. Georeferenced 38 soil surface samples, 8 soil profile samples and 6 plant samples were collected from three land use types- agriculture cropland, fallow land and natural vegetation. Collected samples were analyzed for HM contamination in inductively coupled plasma atomic emission spectrophotometer (ICPAES). The mean total HM concentration in surface soil exceeded the background value. Weak acid soluble fraction % of metals posed no to medium risk values. Fallow land had higher metal content in surface soil. Principal component (PC) analysis showed Pb, Cd and Cr metals were more associated with mining activity. Vertical distribution pattern of HM accumulation in soil profiles showed a drastic reduction in HM concentration below plough layer in fallow land indicating anthropogenic sources of origin. Hazard index (HI) in the descending order were Cd> Cr >Pb. Non-carcinogenic HI value were considerably higher than safe level. Higher organic carbon (OC) and clay content in soil had a tendency to accumulate ample HM in unavailable form due to chelation effect. Soils had higher pool of unavailable residual HM as compared to available. Overall the land uses are in medium risk category and site specific management is requisite of the time to maintain the balance of this fragile ecosystem with anthropogenic activities in long run.
Enzymatic Activities of Halotolerant and Halophilic Fungi Isolated from Iko River Estuary, South-South Nigeria
Authors: Ufot Ekemini A. , Antia Ukponobong E. , Umoh Veronica J. , Udomessien Cheryl K.
Published: October 2022

Aim: Fungi that can tolerate unfavorable conditions are a potential source of stable bioactive metabolites that can be used for various industrial processes. Therefore this study aimed to isolate halotolerant and halophilic fungi from the Iko river estuary and screen them for three industrially important enzymes: amylase, cellulase, and mannanase.

Place and Duration of Study: Department of Microbiology, Akwa Ibom State University, Nigeria, between September 2021 and August 2022.

Methodology: Five sediment-dwelling fungi isolated from three locations along the Iko river estuary were assayed for their halotolerance on PDA containing different NaCl concentrations while their amylolytic, cellulolytic, and mannolytic activities were evaluated on agar plates containing 10% NaCl. The highest producer of the screened enzymes was identified using molecular techniques and further subjected to various submerged fermentation conditions to optimize the production of salt tolerant amylase, cellulase, and mannanase.

Results: All isolates were halotolerant, best adapted to a salinity of 5% NaCl (w/v), and capable of secreting at least one of the three tested enzymes in 10% NaCl (w/v). Aspergillus niger isolate L2S1 had the highest enzymatic index among other isolates thus requiring optimization. The optimum production of amylase, cellulase, and mannanase was obtained at an incubation temperature of 30oC, initial pH of 6.0, and NaCl concentration of 5% (w/v). Out of the tested agro-wastes, wheat bran was most suited for the production of amylase, corncob was optimum for cellulase production, and maximum mannanase yield was obtained using copra meal. Amylase and cellulase production was optimal at 96 hours of incubation, whereas mannanase required 144 hours of fermentation to reach its maximum activity.

Conclusion: Aspergillus niger isolate L2S1 was capable of utilizing different carbon sources including cheap agro-residues as substrates for the production of halostable amylase, cellulase, and mannanase.
Financial Supply Chain & its Implementation in the Banking Sectors of Bangladesh
Authors: Islam Mohammad Ekramol , Das Prince , Alam Mahbub A. , Hanif MD. Abu
Published: October 2022

A drastic changing scenario is observed to manage Financial Supply Chain all over the "World" except Bangladesh. A few Banks or financial institutions in Bangladesh are implementing the concepts of Financial Supply Chain Management to provide benefits to the buyers (Anchors) and suppliers (Vendors). We explored the benefits and challenges of FSC from the management perspective of Bangladesh. The researchers made an effort to support our findings through a case study involving three parties: Bank Asia, Banga Millers limited (a sister concern of PRAN Company), and marginal suppliers. The researchers establish that trios can benefit if a strong Financial Supply Chain system can be established with the help of the latest computer software like VEEFIN. Researchers are aware of the fact that technology makes data transparent and does transaction settlement more successfully. The main objective of this paper is to discover the loopholes and challenges to popularizing the concept of Financial Supply Chain Management in Bangladesh's perspective, to search for benefits for the stakeholders on account of implementing a Financial Supply Chain, and also to find out the potentiality of FSC in Bangladesh perspective in the coming years. The Researchers also made a forecast to identify the amount of disbursement through the Banks or financial institutions five years later to explore the scenario of FSC flow and found that the disbursement amount will be equivalent to twenty core takas by using the least square method. The findings of this research can help financial institutions and banks in favor to introduce the Financial Supply Chain in their organization to provide better services and enhance customer satisfaction.
Determination of In-vitro Optimum Conditions of Xylanase Enzyme Activity Produced by Orpinomyces sp. and Neocallimastix sp.
Authors: Yücel Halit , Koçer Ferudun
Published: October 2022

This study was aimed to determine the in-vitro optimum conditions of xylanase enzyme activity produced by Orpinomyces sp. and Neocallimastix sp. In the study, xylanase enzyme activity was investigated in terms of extracellular and intracellular total activity (TA) and specific activity (SA) levels at different time (day), pH and temperature levels. Orpinomyces sp. and Neocallimastix sp. when different days (time) were considered in terms of xylanase enzyme activity of fungi species, it was determined that there was a statistically significant positive correlation between TA=0.732 and SA=0.546 (p<0.01). It was determined that there was a statistically positive and significant relationship between TA=0.622 and SA= 0.520 at different pH levels. This situation differs in terms of temperature levels. It was determined that there was a statistically negative significant relationship between genders and SA=-0.354 (p<0.05). In this study, it is thought to contribute by determining the optimum conditions in in-vitro and industrial uses.
PERAN GURU DALAM MEMANFAATKAN LINGKUNGAN BELAJAR UNTUK MENOLONG MURID MEMILIKI MOTIVASI BELAJAR
Authors: Lattu Jose Imanuel
Published: October 2022

Penelitian ini dilakukan untuk mengetahui bagaimana guru berperan dalam memanfaatkan lingkungan belajar untuk menolong murid memiliki motivasi belajar di sebuah sekolah swasta Kristen di Surabaya. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Metode pengumpulan data dilakukan melalui observasi dan wawancara mendalam. Teknik analisis data yang digunakan adalah reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa guru berperan sebagai director of learning, pendorong, dan pemimpin Kristen dalam memanfaatkan lingkungan sosial, fisik, serta akademis. Guru sebagai tenaga pendidik berperan penting untuk menolong murid memiliki motivasi belajar melalui pemanfaatan lingkungan belajar. Sebagai pendidik Kristen, guru juga berperan penting dalam pertumbuhan rohani murid.
Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients With COVID-19
Authors: Smith Davey M. , Li Jonathan Z. , Moser Carlee , Yeh Eunice , Currier Judith S. , Chew Kara W. , Hughes Michael D. ,   ACTIV-2/A5401 Study Team, Daar Eric , Wohl David , Eron Joseph , Javan Arzhang C. , Giganti Mark , Ritz Justin , Hosey Lara , Roa Jhoanna , Patel Nilam , Colsh Kelly , Rwakazina Irene , Beck Justine , Seig Scott , Fletcher Courtney , Fischer William , Evering Teresa , Bender Rachel , Cardoso Sandra , Corado Katya , Jagannathan Prasanna , Jilg Nikolaus , Perelson Alan , Pillay Sandy , Riviere Cynthia , Singh Upinder , Taiwo Babafemi , Gottesman Joan , Newell Matthew , Pederson Susan , Dragavon Joan , Jennings Cheryl , Greenfelder Brian , Murtaugh William , Kosmyna Jan , Gapara Morgan , Shahkolahi Akbar , Kim Peter , Erhardt William
Published: October 2022

This cohort study of US adults with untreated COVID-19 examines the types and length of symptoms experienced following symptom recurrence.
Reexamining Social Determinants of Health Data Collection in the COVID-19 Era
Authors: Mullangi Samyukta , Aviki Emeline M. , Hershman Dawn L.
Published: October 2022

This Viewpoint describes the association of various factors, including demographic factors, disease-related factors, and social determinants of health, with cancer treatment delays among a cohort of patients across multiple sites who had all tested positive for SARS-CoV-2.
Analysis of Serious Adverse Event Reporting for Patients Enrolled in Cancer Clinical Trials During the COVID-19 Pandemic
Authors: Ragavan Meera V. , Legaspi Nichole , LaLanne Alyssa , Hong Julian C. , Small Eric J. , Borno Hala T.
Published: October 2022

This cross-sectional study assesses whether a change occurred in reporting of serious adverse events for patients in oncology clinical trials in the US during the COVID-19 pandemic.
A Pigmented Iris Lesion
Authors: Valenzuela Daniel A. , Biscotti Charles V. , Daniels Anthony B.
Published: October 2022

A patient in their mid-60s presented with a left iris pigmented lesion that had been present for decades and remained stable in size. What would you do next?
Considerations on transformation (1984–2018) of kampung and rumah kampung in Surabaya
Authors: Furuta Rikako , Yamagishi Teruki , Shinozaki Kenichi , Hirota Naoyuki , Funo Shuji
Published: October 2022

This paper clarifies the changes in kampungs and their houses (rumah kampungs) over the past 35 years based on field surveys of three kampungs in Surabaya, Indonesia, conducted in 1983/84, 2006, and 2016–2018. The major objective is to develop new policies for the Kampung Improvement Program (KIP) and public housing. The main finding is that most of the kampungs have maintained their basic spatial structure and community organization, although the houses themselves have been transformed. Thus, kampungs in Surabaya continue to maintain their unique characteristics.
Influence of rye/oat cover crop in a two‐year soybean production system
Authors: Overmyer Keeley , Looker Wayde , Dorrance Anne E. , Tilmon Kelley J. , Lindsey Laura E.
Published: October 2022

As the cost of corn (Zea mays L.) production increases, some farmers find continuous soybean [Glycine max (L.) Merr.] to be more profitable than corn–soybean rotation. However, a grass cover crop could help diversify the cropping system. The study objectives were to evaluate planting date and termination timing of a rye (Secale cereale L.)/oat (Avena sativa L.) cover crop mix on cover crop biomass and soybean disease, insects, slugs, and grain yield within a 2‐yr soybean production system. Field trials were conducted in 2018 and 2019 at two locations in Ohio (northwestern and western). The main plot factor was cover crop planting date (September through October) and the subplot factor was cover crop termination timing (2 and 4 wk prior to soybean planting). Cover crop planting date and termination timing had little influence on soybean diseases and insects. Soybean grain yield was influenced by cover crop termination timing at the northwestern location. In 2018, soybean yield was 4% greater when the preceding cover crop was terminated late and in the control (no cover crop) compared to early cover crop termination. The following year, soybean yield was 8% greater when the cover crop was terminated late compared to early termination and the control. At the western location, there was no impact of cover crop termination timing on yield. Late‐terminated cover crops had a positive effect or no effect on yield of the following soybean crop.
Hajdu‐Cheney syndrome with atypical cardiovascular abnormalities
Authors: Ekure Ekanem N. , Sokunbi Ogochukwu , Kruszka Paul , Muenke Maximilian , Adeyemo Adebowale A.
Published: October 2022

Hajdu‐Cheney syndrome is an ultra‐rare autosomal dominant disorder caused by a heterozygous variant in NOTCH2 gene. Characteristic features include osteolysis, distinct facial appearance, skull deformity, joint laxity, osteoporosis, and short stature. Associated abnormalities are congenital heart disease, congenital defects of the kidney, and neurological problems. Here, we present the first reported case of an African child with a variant in NOTCH2 gene and features of Hajdu‐Cheney syndrome in whom we detected a congenital heart defect that has not been previously reported in association with the syndrome. To appropriately characterize this disease and document correct proportion of cardiovascular malformation associations, echocardiography is recommended for all cases of Hajdu Cheney syndrome.