bluuebunny/crossref_metadata_2025 huggingface dataset:
Positive Attitude Upper Middle School social and emotional learning program: influences of implementation quality on program outcome
Authors: Coelho Vítor Alexandre , Marchante Marta , Brás Patrícia
Published: May 2023

Introduction

There is an increased call for studies analyzing how implementation quality influences Social and Emotional Learning (SEL) program effectiveness.

Methods

The current dissemination study analyzed the effectiveness of the Positive Attitude Upper Middle School SEL program on a Portuguese nationwide sample composed of 813 middle school students (7th and 8th grade; 51.7% boys; Mage = 12.41, S.D. = 1.06), from 36 classrooms (Mclassroom = 22.58; S.D. = 2.86), distributed between the control group (179 students), and three intervention groups (643 students) that reflected low, middle, and high implementer experience (respectively, Gulbenkian Academies of Knowledge, Positive Attitude Cadaval and Positive Attitude Torres Vedras). Dosage and fidelity (as implementation quality dimensions), gender, and classroom size (as individual and classroom-level variables) were also analyzed. Self-report questionnaires were administered pre- and post-intervention and at a 6-month follow-up.

Results

Multilevel models were employed, and results showed that participating in the PAUMS SEL program led to more positive trajectories in self-control, social awareness, relationship skills, and responsible decision-making when compared with control groups. Regarding implementation quality, only the implementer’s experience impacted the effectiveness of the PAUMS SEL program; students in the Gulbenkian Academies of Knowledge intervention group displayed a less positive trajectory in self-control than students in the Positive Attitude Torres Vedras intervention group.

Discussion

Altogether, results showed that the PAUMS SEL program is ready for dissemination in Portugal, although a higher level of implementer experience is needed to achieve the best effectiveness, and they support the importance of analyzing implementer experience in SEL programs’ effectiveness studies.
Effects of a Portuguese social–emotional learning program on the competencies of elementary school students
Authors: Coelho Vera , Peixoto Carla , Azevedo Helena , Machado Francisco , Soares Mónica , Espain Andreia
Published: May 2023

Introduction

It is widely recognized that socio-emotional learning (SEL) interventions can contribute to supporting students’ positive development of socio-emotional skills (SES) and positive relationships with peers and teachers. Thus, interest in promoting students’ SES through universal evidence-based programs is spreading around the world, including in Portuguese schools.

Methods

This quasi-experimental study examines the efficacy of a SEL classroom-based program, infused into the curriculum, on students’ communication, self-regulation, and classroom peer relationships. Participants included 208 third- to fourth-grade students from three Portuguese public elementary schools: 143 in the intervention group (54.5% boys; Mage = 8.72; SD = 0.61); 65 in the comparison group (52.3% boys; Mage = 8.66; SD = 0.59). Measures included: Study on Social and Emotional Skills, parent, child, and teacher versions; and Classroom Peer Context Questionnaire, completed by students. The study followed a pre- and post-test design, with a 16-week intervention.

Results

For the overall participants, results show a positive effect of the program on students’ assertiveness (family report), peer conflict and peer cooperation. Effects were analyzed separately by school grade. A statistically significant positive effect of the program on third-grade students’ assertiveness and sociability was found. For fourth-grade students, a positive effect was found on - emotional control). classroom conflicts, isolation, cooperation and cohesion behaviors.

Discussion

These positive effects support the expansion of universal interventions when aiming at strengthening SEL in Portuguese school settings, underlining the relevance of embedding SEL into the curricula and daily practices at schools.
Understanding the mental health needs of Scotland's prison population: a health needs assessment
Authors: Gilling McIntosh Lindsey , Rees Cheryl , Kelly Caroline , Howitt Sheila , Thomson Lindsay D. G.
Published: May 2023

Introduction

This study reports on an assessment of mental health needs among Scotland's prison population which aimed to describe the scale and nature of need as well as identify opportunities to improve upon the services available. The project was commissioned by the Scottish Government to ensure that future changes to the services available to support the mental health and wellbeing of people in prison would be evidence-based and person-centered.

Methods

A standardized approach to health needs assessments was employed. The study was comprised of four phases. In phase I a rapid literature review was undertaken to gather evidence on the prevalence of mental health needs experienced by people in prison in the UK. In Phase II a multi-method and multi-informant national mapping exercise involving providers to all Scottish prisons was undertaken to describe the mental health services available, and any gaps in these services, for people in and leaving prison. In Phase III prevalence estimates of several mental health needs were derived for Scotland's current prison population, modeled from a national survey dataset of Scotland's community population using logistic regression. Finally in Phase IV, professional stakeholders and individuals with lived experience were interviewed to understand their experiences and insights on challenges to supporting the mental health and wellbeing of people in prison, and ideas on how these challenges could be overcome.

Results

Evidence across the four phases of this needs assessment converged indicating that existing provision to support the mental health of people in prison in Scotland was considered inadequate to meet these needs. Barriers to effective partnership working for justice, health, social work and third sector providers appear to have led to inadequate and fragmented care, leaving prisoners without the support they need during and immediately following imprisonment.

Conclusions

Joint and coordinated action from justice, health and social care, and third sector providers is needed to overcome enduring and structural challenges to supporting the mental health of people in prison. Eighteen evidence-based recommendations were proposed to the Scottish Government relating to the high-level and operational-level changes required to adequately meet the prison population's mental health needs.
Acute stress reaction, depression anxiety stress, and job withdrawal behavior in non-frontline pediatric nurses during the pandemic: a cross-sectional study
Authors: Yi Xu , Jing Cao , Meimei Ma , Jianhui Xie , Jihong Hu , Ding Xiang , Lihui Zhu
Published: May 2023

Backgrounds

The COVID-19 pandemic has brought an unprecedented healthy crisis to people worldwide. It is crucial to assess the psychological status of non-frontline nurses. More attention to the mental and physical health of non-frontline nurses during a public health emergency is necessary for a full understanding of the implications. Therefore, this study aims to investigate the factors that influence the acute stress reaction of non-frontline pediatric nurses during the COVID-19 pandemic.

Methods

This study aimed to explore factors associated with acute stress reactions of non-frontline pediatric nurses in Hunan province during the COVID-19 pandemic. This was a cross-sectional design. Five hundred eighteen pediatric nurses from Hunan province, China, completed the Stanford Acute Stress Reaction Questionnaire (SASRQ), Depression Anxiety Stress Scales-21 (DASS-21), and Job Withdrawal Behavior Scales (JWB). Multiple linear regression analyses and Pearson’s correlation were used to analyze the results.

Results

The mean scores of DASS-21, JWB, SASRQ were 1.443 ± 0.500, 1.601 ± 0.544, and 1.858 ± 0.805, respectively. Stress, anxiety, depression (three sub-dimensions of DASS-21), JWB, monthly income and department were the major predictive factors for SASRQ (Adjusted R2 = 0.579, p < 0.001). Pearson’s correlation showed that the mean score of SASRQ was positively correlated with JWB, DASS-21, and all its dimensions (p < 0.01).

Conclusion

The study indicated that the SASRQ was greater with higher levels of DASS-21 and JWB. It revealed an acute stress reaction in non-frontline pediatric nurses and recommends more focus on the factors influencing the SASRQ.
Clinical characteristics and prescriptions associated with a 2-year course of rapid cycling and euthymia in bipolar disorder: a multicenter treatment survey for bipolar disorder in psychiatric clinics
Authors: Takano Chikashi , Kato Masaki , Adachi Naoto , Kubota Yukihisa , Azekawa Takaharu , Ueda Hitoshi , Edagawa Kouji , Katsumoto Eiichi , Goto Eiichiro , Hongo Seiji , Miki Kazuhira , Tsuboi Takashi , Yasui-Furukori Norio , Nakagawa Atsuo , Kikuchi Toshiaki , Watanabe Koichiro , Kinoshita Toshihiko , Yoshimura Reiji
Published: May 2023

Objective

In patients with bipolar disorder (BD), rapid cycling (RC) presents a risk for a more severe illness, while euthymia (EUT) has a better prognosis. This study focused on the progression of RC and EUT, which are contrasting phenomenology, and aimed to clarify the influence of patient backgrounds and prescription patterns on these different progressions, using a large sample from the first and second iterations of a multicenter treatment survey for BD in psychiatric clinics (MUSUBI).

Methods

In the cross-sectional study (MUSUBI), a questionnaire based on a retrospective medical record survey of consecutive BD cases (N = 2,650) was distributed. The first survey was conducted in 2016, and the second one in 2017. The questionnaire collected information on patient backgrounds, current episodes, and clinical and prescribing characteristics.

Results

In the first survey, 10.6% of the participants had RC and 3.6% had RC for two consecutive years, which correlated with BP I (Bipolar disorder type I), suicidal ideation, duration of illness, and the use of lithium carbonate and antipsychotic medications. Possible risk factors for switching to RC were comorbid developmental disorders and the prescription of anxiolytics and sleep medication. Moreover, 16.4% of the participants presented EUT in the first survey, and 11.0% presented EUT for two consecutive years. Possible factors for achieving EUT included older age; employment; fewer psychotic symptoms and comorbid personality disorders; fewer antidepressants, antipsychotics, and anxiolytics, and more lithium prescriptions.

Conclusion

RC and EUT generally exhibit conflicting characteristics, and the conflicting social backgrounds and factors contributing to their outcomes were distinctive. Understanding these clinical characteristics may be helpful in clinical practice for management of patients with BD.
Application of plant extended phenotypes to manage the agricultural microbiome belowground
Authors: Favela Alonso , Bohn Martin O. , Kent Angela D.
Published: May 2023

Plants have a surprising capacity to alter their environmental conditions to create adequate niches for survival and stress tolerance. This process of environmental transformation, commonly referred to as “extended phenotypes” or “niche construction”, has historically been studied in the domain of ecology, but this is a process that is pervasive across the plant kingdom. Furthermore, research is beginning to show that plants’ extended phenotypes shape the assembly and function of closely associated microbial communities. Incorporation and understanding the role that plant-extended phenotypes play in agriculture may offer novel, bioinspired methods to manage our arable soil microbiomes. Here, we review the challenges agriculture faces, the plant extended phenotypes we know to shape the microbiome, and the potential utilization of this knowledge to improve the environmental impact of agriculture. Understanding how plant extended phenotypes shape microbial communities could be a key to creating a sustainable future with both plants and microbiomes in consideration.
Cable failure tolerant control and planning in a planar reconfigurable cable driven parallel robot
Authors: Raman Adhiti , Walker Ian , Krovi Venkat , Schmid Matthias
Published: May 2023

The addition of geometric reconfigurability in a cable driven parallel robot (CDPR) introduces kinematic redundancies which can be exploited for manipulating structural and mechanical properties of the robot through redundancy resolution. In the event of a cable failure, a reconfigurable CDPR (rCDPR) can also realign its geometric arrangement to overcome the effects of cable failure and recover the original expected trajectory and complete the trajectory tracking task. In this paper we discuss a fault tolerant control (FTC) framework that relies on an Interactive Multiple Model (IMM) adaptive estimation filter for simultaneous fault detection and diagnosis (FDD) and task recovery. The redundancy resolution scheme for the kinematically redundant CDPR takes into account singularity avoidance, manipulability and wrench quality maximization during trajectory tracking. We further introduce a trajectory tracking methodology that enables the automatic task recovery algorithm to consistently return to the point of failure. This is particularly useful for applications where the planned trajectory is of greater importance than the goal positions, such as painting, welding or 3D printing applications. The proposed control framework is validated in simulation on a planar rCDPR with elastic cables and parameter uncertainties to introduce modeled and unmodeled dynamics in the system as it tracks a complete trajectory despite the occurrence of multiple cable failures. As cables fail one by one, the robot topology changes from an over-constrained to a fully constrained and then an under-constrained CDPR. The framework is applied with a constant-velocity kinematic feedforward controller which has the advantage of generating steady-state inputs despite dynamic oscillations during cable failures, as well as a Linear Quadratic Regulator (LQR) feedback controller to locally dampen these oscillations.
Deterritorialization in the context of cultural heritage and globalizing Msheireb downtown Doha
Authors: Al-Hammadi Mariam Ibrahim
Published: May 2023

The State of Qatar has witnessed rapid urban activity and development in the decades since the discovery of oil, which has led to a large-scale change in the local cultural heritage and behavior of its residents. This uncontrolled rapid urbanization, along with the acceleration of globalization and modernity that has encompassed all areas, especially the city of Doha, has led to the deterioration and destruction of the downtown area of Msheireb. These transformations threaten the identity and local culture of Qatari society, affecting the place's sense of identity. The country's authorities have rushed to implement strategies and development plans aimed at redeveloping the old city center and improving the environment by creating innovative and inspiring living spaces that enable both locals and foreigners to communicate and integrate with one another to restore a sense of community. This study addresses the “Msheireb Downton Doha” project and the consequences of globalization. The study examines the concept of “deterritorialization” as a cultural condition that has pushed Msheireb Downtown Doha from modernity to postmodernism as an element of globalization. In this study, we will analyze the reconstruction of Msheireb, which helped to move the city toward cultural universality while simultaneously reducing regional borders. The study will analyze the extent to which this process succeeded or failed in preserving the spirit of the area's traditional architectural heritage and cultural identity in a manner that reflects the genuine sentiments and values of Qatari society.
The quality of life after trans oral video-assisted thyroidectomy and cervical thyroidectomy: a systematic review and meta-analysis
Authors: Altedlawi Albalawi Ibrahim A. , Mirghani Hyder Osman
Published: May 2023

Trans oral video-assisted thyroidectomy (TOVAT) is increasingly performed for cosmetic reasons. The quality of life after thyroidectomy is important for decision-making. This is the first meta-analysis to compare the quality of life among conventional transcervical thyroidectomies. This meta-analysis aimed to assess the same in the current literature. The authors systematically searched PubMed, Google Scholar, and EBSCO for relevant articles from the first published to December 4, 2022. The keywords endoscopic transoral via vestibular thyroidectomy, transcervical thyroidectomy, conventional thyroidectomy, scarless thyroidectomy, and quality of life were used. Out of the 482 studies retrieved, 27 full texts were reviewed, and only six fulfilled the inclusion and exclusion criteria. Patients with transoral thyroidectomy showed better quality of life that their counterparts who underwent transcervical thyroidectomy at 4–6 weeks following surgery, odd ratio, 2.26, 95% CI, 2.02–2.5, P-value <0.001. Substantial heterogeneity was observed, I2 for heterogeneity, 100%. The quality of life was better among patients who underwent the trans oral video-assisted thyroidectomy (TOVAT) compared to their counterparts with the conventional cervical approach (surgical questionnaire). All the components of the SF-36 quality of life questionnaire were better among TOVAT compared to the conventional approach except for social and general health components, which were equal between the two arms. Further multi-center studies with larger samples and controlling for pain and the surgical curve are needed.
New perspective on African swine fever: a bibliometrics study and visualization analysis
Authors: Yu Zhengyu , Xie Li , Shuai Peiqiang , Zhang Jing , An Wei , Yang Miao , Zheng Jing , Lin Hua
Published: May 2023

Introduction

African swine fever (ASF) is a contagious viral disease that can have devastating effects on domestic pigs and wild boars. Over the past decade, there has been a new wave of this ancient disease spreading around the world, prompting many scholars to dedicate themselves to researching this disease. This research aims to use bibliometric methods to organize, analyze and summarize the scientific publications on ASF that have been amassed in the past two decades.

Methods

This paper used VOSviewer, CiteSpace, and a bibliometric online analysis platform to conduct performance analysis and visualization studies on 1,885 academic papers about ASF in the Web of Science from January 2003 to December 2022.

Results

The amount of literature published on ASF has increased exponentially in recent years, and the development trend of related research is good. A group of representative scholars have appeared in this research field, and some cooperative networks have been formed. Transboundary and Emerging Diseases is the journal with the most publications in this field, while Virus Research is the journal with the most citation per article. High-productivity countries are led by China in terms of the number of articles published followed by the United States and Spain. In regard to the average number of citations, the scholars in the UK are in the lead. The institution with the most articles was the Chinese Academy of Agricultural Sciences. The analysis of high-frequency keywords showed that the pathogens and epidemiology of ASF were the research hotspots in this field, and the research content was closely related to molecular biology and immunology. The burst keywords “transmission”, “identification”, “virulence”, “replication”, and “gene” reflects the research frontier. In addition, by collating and analyzing highly cited journals and highly co-cited references, we explored the knowledge structure and theoretical basis of this field.

Discussion

This is the first bibliometric analysis report on ASF research, which highlights the key characteristics of ASF research and presents the research status and evolution trend in this field from a new perspective. It provides a valuable reference for further research.
Unraveling the epidemiology of Mycobacterium bovis using whole-genome sequencing combined with environmental and demographic data
Authors: Rossi Gianluigi , Shih Barbara Bo-Ju , Egbe Nkongho Franklyn , Motta Paolo , Duchatel Florian , Kelly Robert Francis , Ndip Lucy , Sander Melissa , Tanya Vincent Ngwang , Lycett Samantha J. , Bronsvoort Barend Mark , Muwonge Adrian
Published: May 2023

When studying the dynamics of a pathogen in a host population, one crucial question is whether it transitioned from an epidemic (i.e., the pathogen population and the number of infected hosts are increasing) to an endemic stable state (i.e., the pathogen population reached an equilibrium). For slow-growing and slow-evolving clonal pathogens such as Mycobacterium bovis, the causative agent of bovine (or animal) and zoonotic tuberculosis, it can be challenging to discriminate between these two states. This is a result of the combination of suboptimal detection tests so that the actual extent of the pathogen prevalence is often unknown, as well as of the low genetic diversity, which can hide the temporal signal provided by the accumulation of mutations in the bacterial DNA. In recent years, the increased availability, efficiency, and reliability of genomic reading techniques, such as whole-genome sequencing (WGS), have significantly increased the amount of information we can use to study infectious diseases, and therefore, it has improved the precision of epidemiological inferences for pathogens such as M. bovis. In this study, we use WGS to gain insights into the epidemiology of M. bovis in Cameroon, a developing country where the pathogen has been reported for decades. A total of 91 high-quality sequences were obtained from tissue samples collected in four abattoirs, 64 of which were with complete metadata. We combined these with environmental, demographic, ecological, and cattle movement data to generate inferences using phylodynamic models. Our findings suggest M. bovis in Cameroon is slowly expanding its epidemiological range over time; therefore, endemic stability is unlikely. This suggests that animal movement plays an important role in transmission. The simultaneous prevalence of M. bovis in co-located cattle and humans highlights the risk of such transmission being zoonotic. Therefore, using genomic tools as part of surveillance would vastly improve our understanding of disease ecology and control strategies.
Influence of Azadirachta indica and Cnidoscolus angustidens aqueous extract on cattle ruminal gas production and degradability in vitro
Authors: Elghandour Mona M. M. Y. , Acosta-Lozano Néstor , Alvarado Tonantzin Díaz , Castillo-Lopez Ezequias , Cipriano-Salazar Moises , Barros-Rodríguez Marcos , Inyang Udoh Akpan , Purba Rayudika Aprilia Patindra , Salem Abdelfattah Z. M.
Published: May 2023

Introduction

Mitigation of ruminant greenhouse gas (GHG) emissions is crucial for more appropriate livestock production. Thus, there is a need of further research evaluating feed supplementation strategies to mitigate enteric GHG emissions and other gases produced within the rumen.

Methods

This study was conducted as a completely randomized experimental design to determine the effectiveness of liquid extracts fromA. indica(AZI),C. angustidens(CNA), or their combination (Mix. 1:1) at dosages of 0, 36, 72, and 108 mg of liquid extract/g DM substrate incubated in reducing GHG productionin vitro, particularly methane (CH4), from the diet of steers during anaerobic incubation in rumen fluid. Total gas production, CH4, CO, H2S, and fermentative characteristics were all measuredin vitro.

Results

Treatment AZI at a dose of 108 mg of liquid extract/g DM substrate produced the highest (P< 0.05) gas volume at 6 h, whereas CNA at a dose of 72 mg of liquid extract/ g DM substrate produced the least (P< 0.05) at 6 and 24 h, and Mix. at a dose of 72 mg of liquid extract/g DM substrate produced the least (P < 0.05) at 48 h. In addition, CH4 levels at 6 and 24 h of incubation (36 mg/g DM substrate) were highest (P< 0.05) for CNA, and lowest (P< 0.05) for AZI, whereas this variable was lowest (P< 0.05) at 72 mg of liquid extract for CNA at 24 and 48 h. At 6 and 24 h, CO volume was highest (P< 0.05) for AZI at 108 mg of liquid extract and lowest (P< 0.05) for Mix. at 72 mg of liquid extract. Treatment Mix. had a high (P< 0.05) concentration of short chain fatty acids at 72 mg of liquid extract/g DM of substrate.

Discussion

In general, herbaceous perennial plants, such as AZI and CNA, could be considered suitable for mitigating enteric GHG emissions from animals. Specifically, the treatment Mix. achieved a greater sustainable reduction of 67.6% in CH4 and 47.5% in H2S production when compared to either AZI. This reduction in CH4 might suggest the potential of the combination of both plant extracts for mitigating the production of GHG from ruminants.
Multiplex analysis of cytokines in the cerebrospinal fluid of dogs after ischemic stroke reveals elevations in chemokines CXCL1 and MCP-1
Authors: Barber Renee M. , Platt Simon R. , De Risio Luisa , Barber Jamie , Robinson Kelsey R.
Published: May 2023

Introduction

Neuroinflammation that occurs in the brain after stroke has been shown to be important to disease pathogenesis and outcomes. The aim of this study was to evaluate a large number of pro- and anti-inflammatory cytokines in dogs with clinically-confirmed, naturally occurring stroke.

Materials and methods

Fifteen dogs with a clinical diagnosis of ischemic stroke and ten healthy control dogs were included in the study. A multiplex immunoassay was utilized to evaluate cerebrospinal fluid for GM-CSF, IFN-γ, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, IP-10, CXCL1, MCP-1, and TNF-α.

Results

Mean concentrations of CXCL1 (stroke-436 pg/ml, control-267 pg/ml, p = 0.01) and MCP-1 (stroke-196 pg/ml, control-66 pg/ml, p ≤ 0.0001) were significantly elevated in dogs with stroke when compared with control dogs. Location and type of infarct, duration of clinical signs, and use of anti-inflammatory medications were not associated with differences in cytokine concentration.

Discussion

CXCL1 and MCP-1 may play a role in naturally occurring canine stroke and represent targets for future research.
Canine and feline papillomaviruses: an update
Authors: Medeiros-Fonseca Beatriz , Faustino-Rocha Ana I. , Medeiros Rui , Oliveira Paula A. , Gil da Costa Rui M.
Published: May 2023

Papillomaviruses are small viruses able to cause disease not only in mammalians, but also in birds and reptiles. In recent years, a rising number of papillomaviruses have been identified in dogs and cats, totaling 24 canine papillomavirus (CPV) and six feline papillomavirus (FcaPV). The canine and feline papillomaviruses (CPVs and FcaPVs, respectively) are responsible for multiple lesions in these domestic species but the potential pathological relevance of some recently identified types remains to be determined. CPVs are associated with oral papillomatosis, cutaneous papillomas and viral pigmented plaques, and have been rarely associated with the development of oral and cutaneous squamous cell carcinomas in their canine hosts. FcaPVs are associated with oral papillomas, viral plaques, and Bowenoid in situ carcinomas. The present review provides readers with the more recent advances on dog and cat papillomavirus research, bringing an update on this field to both veterinary practitioners and the virology community at large.
Metabolic Outcomes After Pancreas Transplant Alone From Donation After Circulatory Death Donors-The UK Transplant Registry Analysis
Authors: Gopal Jeevan Prakash , McLean Adam , Muthusamy Anand
Published: May 2023

Extrapolating data from early DCD (donation after circulatory death) kidney transplantation, pancreas transplants from DCD grafts were feared to have worse metabolic outcomes. Hence, we aimed to address the question of pancreas transplant alone (PTA) from DCD donors–are our concerns justified? A UK transplant registry analysis of 185 PTA performed between 2005 and 2018 was done. All early graft losses (<3 months) were excluded to allow focus on the metabolic outcomes (HbA1c, weight gain and incidence of secondary diabetic macrovascular complications). The aim was to compare the metabolic outcomes, rejection rates (including the need for steroids), patient and graft survival between DBD (Donation after brainstem death) and DCD groups. After excluding early graft losses, data from 162 PTA (DBD = 114 and DCD = 48) were analyzed. Body mass index of the donor was less in DCD group (DBD = 23.40 vs. DCD = 22.25, p = 0.006) and the rest of the baseline transplant characteristics were comparable. There were no significant differences in the HbA1c, weight gain, rejection rate, and incidence of secondary diabetic macrovascular complications post-transplant between DBD and DCD recipients. The 1-, 5-, and 10-year patient and graft survival were similar in both the groups. PTA from DCD donors have equivalent metabolic outcomes and survival (patient/graft) as that of DBD donors.
A Tool for the Design of Turbomachinery Disks for an Aero-Engine Preliminary Design Framework
Authors: Kolias Ioannis , Aretakis Nikolaos , Alexiou Alexios , Mathioudakis Konstantinos
Published: May 2023

Disks in gas turbines are optimized for minimum weight, while satisfying both geometry and stress constraints, in order to minimize the engine production, operation, and maintenance costs. In the present paper, a tool is described for the preliminary mechanical design of gas turbine disks. A novel formulation is presented, where the disk weight minimization is achieved by maximizing the stresses developed in the disk. The latter are expressed in the form of appropriately defined design and burst margins. The computational capabilities of the tool developed are demonstrated through comparisons to calculations with a higher fidelity tool. The importance of accurately calculating thermal stresses is demonstrated and the ability of the tool for such calculations is discussed. The potential and efficiency of the tool are illustrated through a proposed re-design of the disks of a well-documented ten-stage compressor. Finally, the integration of the tool into an overall engine design framework is discussed.
A Flexible Code Review Framework for Combining Defect Detection and Review Comments
Authors: Chen Xi , Dong Lei , Li Hong-Chang , Yao Xin-Peng , Wang Peng , Yao Shuang
Published: May 2023

Defects and errors in code are different in that they are not detected by editors or compilers but pose a potential risk to software operation. For safety-critical software such as airborne software, the code review process is necessary to ensure the proper operation of software applications and even an aircraft. The traditional manual review method can no longer meet the current needs with the dramatic increase in code sizes and variety. To this end, we propose Deep Reviewer, a general and flexible code review framework that automatically detects code defects and correlates the review comments of the defects. The framework first preprocesses the data using several methods, including the proposed D2U flow. Then, features are extracted and matched by the detector, which contains a pair of twin LSTM models, one for code defect type detection and the other for review comment retrieval. Finally, the review comment output function is implemented based on the masks generated by the code defect types. The method is validated using a large public dataset, SARD. For the binary-classification task, the test results of the proposed are 98.68% and 98.67% in terms of precision and F1 score, respectively. For the multi-classification task, the proposed framework shows a significant advantage over other methods.
Microbial Phytase in a Diet with Lupine and Extruded Full-Fat Soya Seeds Affects the Performance, Carcass Characteristics, Meat Quality, and Bone Mineralization of Fatteners
Authors: Buzek Anna , Zaworska-Zakrzewska Anita , Muzolf-Panek Małgorzata , Kasprowicz-Potocka Małgorzata
Published: May 2023

This study aims to determine how different doses of phytase in diets including extruded soya and lupine seeds affect fatteners’ performance, meat quality, bone mineralization, and fatty acid profile. Sixty pigs were divided into three treatment groups. The control group was offered a diet without phytase, whereas the Phy100 and Phy400 groups were provided with 100 g and 400 g of phytase per ton of their diet, respectively. The animals from both experimental groups were characterized by a significantly (p < 0.05) higher body weight gain and lower feed efficiency in the starter period than the control group. Unfortunately, their meat had lower (p < 0.05) fat content, gluteal muscle thickness, and water-holding capacity. In the meat, a higher phosphorus content (p < 0.05) was found, and in the bones, a higher calcium (for Phy400) content was found when phytase was added to the pigs’ diet. The pigs from the Phy100 group tended to have higher mean backfat thickness and C18:2 n-6 content in their fat, but lower C22:5 n-3 content, than the other groups. A higher dosage of phytase is not necessary for the diets of fatteners with extruded full-fat soya and lupin seeds.
Seed Morpho-Anatomy and Germination Enhancement of the Australian Native Species Lomandra longifolia Labill. and L. hystrix (R.Br.) L.R. Fraser & Vickery
Authors: Beveridge Fernanda Caro , Williams Alwyn , Cave Robyn , Kalaipandian Sundaravelpandian , Adkins Steve W.
Published: May 2023

Lomandra species are an important understory component of many Australian native ecosystems, contributing to the floristic richness and stabilizing soils. However, a limited understanding of their germination biology currently hinders their efficient use in seed-based restoration and ornamental plant production. The present study investigated Lomandra longifolia and L. hystrix diaspore morpho-anatomy and evaluated different mechanical and/or chemical treatments (nicking, leaching, smoke water and gibberellic acid [GA3]) and under light or dark conditions to enhance germination. Embryos of both species were small and linear with a low embryo to seed ratio (<0.45). Germination rates of both species were significantly hastened by leaching seeds in running water for 36 h as compared to a non-leached seed. The results suggest that pre-treating both Lomandra species by leaching could maximize the effectiveness of seed used by resulting in faster, more uniform and, therefore, reliable germination of these species. Finally, seeds of L. longifolia had low final germination (<40%), with a high presence of viable but dormant seeds. The ecological cues that promote germination in nature for both species should be further examined.
Morphological Diversity of Different Male Morphotypes of Giant Freshwater Prawn Macrobrachium rosenbergii (De Man, 1879)
Authors: Ibrahim Salifu , Zhong Zhenxiao , Lan Xuan , Luo Jinping , Tang Qiongying , Xia Zhenglong , Yi Shaokui , Yang Guoliang
Published: May 2023

The giant freshwater prawn (GFP), Macrobrachium rosenbergii, is one of the largest palaemonids in the world, found in tropical marine, estuarine, and freshwaters, and is among the most commercially cultured crustaceans. According to research, mature males usually develop differences in cheliped morphology, growth characteristics, and agonistic behavior. The identification of such morphotypes is critical for effectively managing and handling prawns. The present study aimed to describe the GFP male population structure in culture ponds (the Yangtze River delta, China). Sixteen morphometric traits and four weight data were measured for each four male morphotype. Principal component and clustering analyses were conducted to investigate the morphological variation among the four morphotypes. The study of relative growth was also employed to estimate the growth patterns of body structures (dependent variables) in relation to the carapace length (independent variable). A detailed description of the cheliped’s macroscopic characteristics that differed among morphotypes was provided, which corroborated with previous studies of the species. The four morphotypes were statistically different regarding the cheliped morphology, size, and morphometric relationships and equations, indicating a considerable variation in growth among the four male morphotypes. The present results contribute to a clear understanding of the population biology of GFP and support future management and broodstock selection activities.
Roda and Terreiro: The Historiography of Brazil’s Visual Arts at the Crossroads of Globalization
Authors: Conduru Roberto
Published: May 2023

The article focuses on Brazil’s visual arts historiography from the 1990s onwards when institutions in Europe and the U.S. began to present Brazil’s art more frequently amid the growing globalization of the art system. Edge cases are highlighted to demonstrate how scholars based outside Brazil are helping to build a canon of that country’s visual arts that contrasts and surpasses the canon of Brazil’s visual arts outlined in Brazil’s collections, exhibitions, publications, and scholarly production. The image of roda (circle) in Ronald Duarte’s Nimbo/Oxalá and Ricardo Basbaum’s image/idea of “terreiro de encontros” (terrace of encounters) are proposed as Afro-Brazilian references with which to face the challenges of these historiographic crossroads.
Formation Mechanisms of the “5·31” Record-Breaking Extreme Heavy Rainfall Process in South China in 2021
Authors: Chen Fangli , Li Huiqi , Hu Sheng , Jiang Shuai , Li Jiaojiao , Wu Ruoting
Published: May 2023

Based on the fifth-generation European Center for Medium-Range Weather Forecasts reanalysis data (ERA5), the real-time observation data from weather stations, and the radar products in Guangdong Province, we analyze the precipitation properties and formation mechanisms of the “5·31” extreme heavy rainfall process with record-breaking 3-h accumulated rainfall in South China during 2021. The results show that the extreme heavy rainfall process is caused by the joint actions of weather systems such as a weak upper-level short-wave trough, a surface stationary front, and a low-level southwesterly jet. Before the heavy precipitation process, there is large precipitable water content and deep warm clouds, which provides a potential for the occurrence and development of the heavy rainfall process in Longhua Town of Longmen County and its surrounding areas. Simultaneously, the low-level southwesterly jet provides abundant warm-wet water vapor for the heavy rainfall area. The vertical atmospheric environmental conditions, such as strong horizontal temperature gradient, high convective available potential energy, high-temperature difference between 850 hPa and 500 hPa, and low convective inhibition, maintain for a long duration in the heavy rainfall area, which are favorable for the occurrence and development of high-efficiency convective precipitation caused by water vapor condensation due to the uplift of low-level warm-wet airflows. The combined effects of the enhanced low-level southwesterly airflow, the stationary front, the mesoscale surface convergence line generated by cold pool outflows, the terrain influence, and the train effect of the precipitation echoes make heavy precipitation near Longhua last longer and stronger than other areas, leading to the extreme heavy rainfall with the record-breaking 3-h accumulated rainfall in Longhua.
Driving Forces on the Distribution of Urban Ecosystem’s Non-Point Pollution Reduction Service
Authors: Shu Chengji , Du Kaiwei , Han Baolong , Chen Zhiwen , Wang Haoqi , Ouyang Zhiyun
Published: May 2023

In the context of increasing urbanization and worsening environmental pollution, nonpoint source pollution during high-frequency rainfall has become a major ecological problem that endangers residents in cities. This study takes Shenzhen as an example. On the basis of a large number of soil sample test data, and combined with relevant environmental variables, it has drawn the high-resolution, high-precision spatial distribution maps of soil attributes within the city. In addition, this paper combines the revised universal soil loss equation and the GeoDetector model to evaluate the supply capacity of nonpoint source reduction services in the city’s ecological space and the main driving factors of spatial distribution characteristics for different types of land. The study found that increasing soil point density and combining environmental variables can help improve the accuracy of spatial mapping for soil attributes. The ME, MSE, ASE, RMSE, and RMSSE of spatial mapping all meet the accuracy evaluation criteria and are better than many existing studies; the spatial distribution characteristics of soil attributes and nonpoint source reduction services show significant differences among the whole city, secondary administrative regions, and different types of land; the GeoDetector results show that among the three main types of land use (forested land, industrial land, and street town residential land), topographic factors, habitat-quality factors, and ecosystem types have the greatest impact on the spatial differentiation characteristics of nonpoint source reduction services. Among climate factors, only precipitation factors have the greatest impact on the spatial differentiation characteristics of services. Facing the above factors, the q-values calculated by the GeoDetector are all higher than 10%. The results of this study can provide information for making better decisions on regional ecological system management and soil protection and on restoration work aimed at improving nonpoint source reduction services.
The Effect of Pulling Angle on Rotator Cuff Mechanical Properties in a Canine In Vitro Model
Authors: Liu Qian , Qi Jun , Zhu Weihong , Thoreson Andrew R. , An Kai-Nan , Steinmann Scott P. , Zhao Chunfeng
Published: May 2023

The objective of this study was to examine the effect of pulling angle on time-zero mechanical properties of intact infraspinatus tendon or infraspinatus tendon repaired with the modified Mason-Allen technique in a canine model in vitro. Thirty-six canine shoulder samples were used. Twenty intact samples were randomly allocated into functional pull (135°) and anatomic pull (70°) groups (n = 10 per group). The remaining sixteen infraspinatus tendons were transected from the insertion and repaired using the modified Mason-Allen technique before being randomly allocated into functional pull or anatomic pull groups (n = 8 per group). Load to failure testing was performed on all specimens. The ultimate failure load and ultimate stress of the functional pulled intact tendons were significantly lower compared with anatomic pulled tendons (1310.2 ± 167.6 N vs. 1687.4 ± 228.2 N, p = 0.0005: 55.6 ± 8.4 MPa vs. 67.1 ± 13.3 MPa, p = 0.0334). For the tendons repaired with the modified Mason-Allen technique, no significant differences were observed in ultimate failure load, ultimate stress or stiffness between functional pull and anatomic pull groups. The variance of pulling angle had a significant influence on the biomechanical properties of the rotator cuff tendon in a canine shoulder model in vitro. Load to failure of the intact infraspinatus tendon was lower at the functional pulling position compared to the anatomic pulling position. This result indicates that uneven load distribution across tendon fibers under functional pull may predispose the tendon to tear. However, this mechanical character is not presented after rotator cuff repair using the modified Mason-Allen technique.
The Impact of Nutrient Limitation and Harvest Method on the Wet Preservation of Chlorella vulgaris Biomass
Authors: Verspreet Joran , Kuchendorf Christina , Ackermann Bärbel , Bastiaens Leen
Published: May 2023

The temporary storage of wet algae concentrates enables the decoupling in time of algae harvests and their biorefinery. However, the impact of cultivation and of the harvest conditions on algae quality during preservation is largely unknown. This study aimed to determine the impact of nutrient limitation and of harvest methods on the preservation of Chlorella vulgaris biomass. Algae were either well-fed until harvest or received no nutrients for one week, and were harvested by either batch or continuous centrifugation. The organic acid formation, lipid levels, and lipolysis were monitored. Nutrient limitation had a large impact and resulted in lower pH values (4.9 ± 0.4), high levels of lactic acid and acetic acid, and a slightly higher degree of lipid hydrolysis. Concentrates of well-fed algae had a higher pH (7.4 ± 0.2) and another pattern of fermentation products with mainly acetic acid, succinic acid, and, to a smaller extent, lactic acid and propionic acid. The effect of the harvest method was smaller, with, most often, higher lactic acid and acetic acid levels for algae harvested by continuous centrifugation than for those obtained by batch centrifugation. In conclusion, nutrient limitation, a well-known method to enhance algae lipid levels, can impact several quality attributes of algae during their wet storage.
Pharmacokinetics of Biopharmaceuticals: Their Critical Role in Molecular Design
Authors: Ogihara Takuo , Mizoi Kenta , Ishii-Watabe Akiko
Published: May 2023

Biopharmaceuticals have developed rapidly in recent years due to the remarkable progress in gene recombination and cell culture technologies. Since the basic structure of biopharmaceuticals can be designed and modified, it is possible to control the duration of action and target specific tissues and cells by kinetic modification. Amino acid sequence modifications, albumin fusion proteins, polyethylene glycol (PEG) modifications, and fatty acid modifications have been utilized to modify the duration of action control and targeting. This review first describes the position of biopharmaceuticals, and then the kinetics (absorption, distribution, metabolism, elimination, and pharmacokinetics) of classical biopharmaceuticals and methods of drug quantification. The kinetic innovations of biopharmaceuticals are outlined, including insulin analog, antibody-related drugs (monoclonal antibodies, Fab analogs, Fc analogs, Fab-PEG conjugated proteins, antibody-drug conjugates, etc.), blood coagulation factors, interferons, and other related drugs. We hope that this review will be of use to many researchers interested in pharmaceuticals derived from biological components, and that it aids in their knowledge of the latest developments in this field.
Myogenesis in C2C12 Cells Requires Phosphorylation of ATF6α by p38 MAPK
Authors: Pagliara Valentina , Amodio Giuseppina , Vestuto Vincenzo , Franceschelli Silvia , Russo Nicola Antonino , Cirillo Vittorio , Mottola Giovanna , Remondelli Paolo , Moltedo Ornella
Published: May 2023

Activating transcription factor 6α (ATF6α) is an endoplasmic reticulum protein known to participate in unfolded protein response (UPR) during ER stress in mammals. Herein, we show that in mouse C2C12 myoblasts induced to differentiate, ATF6α is the only pathway of the UPR activated. ATF6α stimulation is p38 MAPK-dependent, as revealed by the use of the inhibitor SB203580, which halts myotube formation and, at the same time, impairs trafficking of ATF6α, which accumulates at the cis-Golgi without being processed in the p50 transcriptional active form. To further evaluate the role of ATF6α, we knocked out the ATF6α gene, thus inhibiting the C2C12 myoblast from undergoing myogenesis, and this occurred independently from p38 MAPK activity. The expression of exogenous ATF6α in knocked-out ATF6α cells recover myogenesis, whereas the expression of an ATF6α mutant in the p38 MAPK phosphorylation site (T166) was not able to regain myogenesis. Genetic ablation of ATF6α also prevents the exit from the cell cycle, which is essential for muscle differentiation. Furthermore, when we inhibited differentiation by the use of dexamethasone in C2C12 cells, we found inactivation of p38 MAPK and, consequently, loss of ATF6α activity. All these findings suggest that the p-p38 MAPK/ATF6α axis, in pathophysiological conditions, regulates myogenesis by promoting the exit from the cell cycle, an essential step to start myoblasts differentiation.