bluuebunny/crossref_metadata_2025 huggingface dataset:
ХОЛІЗМ ЯК ПРИЧИННО-СИСТЕМНИЙ ПІДХІД ДО ЦІЛІСНОСТІ ЛЮДИНИ
Authors: Odynets Oksana , Shabanova Yulia
Published: January 2023

У статті розглядається концепція холізму в антропологічному вимірі, що дозволяє виявити еквівокацію різноспрямованих параметрів холізму: духовність як причинність - низхідний вектор розвитку з надсистеми та цілєорієнтованість - висхідний вектор розвитку. Синтезуюча єдність вертикальних і горизонтальних компонентів холізму спирається на принципи саморозвитку та самоорганізації цілісної системи. Основними характеристиками холізму визначаються принципи: цілеорієнтованості, ієрархічності, циклічності, самоорганізації. Духовність як необ’єктивована, нерозкладна трансцендентність в межах холізму визначається вищою надсистемою – причиною універсальної цілісності. Відповідно холістичної онтології людина, як причинно-холістична система, прагне цілісної реалізації, зорентованої на духовність. Порушення цілісності в обмежених формах реалізації людини містить небезпеку відхилень у сфері психічного та фізичного здоров’я. Відповідно причинно-системний підхід до цілісності людини та її розвитку містить перспективи оновленого погляду на місце та роль людини у світі, перегляд концептуальних питань виховання, освіти та відновлення здоров’я людини.
Investigation of NDM-1 and OXA-48 producing carbapenem resistant Klebsiella pneumoniae ST15 in Iran
Authors: Mohajer Hedayat Bozorgi , Salimizand Himen , Gharanizadeh Dahieh , Hossainpanahi Afra , Ramazanzadeh Rashid
Published: January 2023

The aim of this study was to determine the frequency of carbapenem resistant Klebsiella pneumoniae (CRKP) sequence types (STs) in Iran. Samples were collected from three university hospitals in Sanandaj, Iran, from December 2016 to March 2018. Antibiotic susceptibility testing, phenotypic and genotypic detection of carbapenemases were performed. Common K. pneumoniae capsular types were sought for all isolates. The genetic relatedness of isolates was investigated by multilocus sequence typing (MLST). Plasmids were detected by PCR-based Replicon Typing (PBRT). During the study, 67 K. pneumoniae isolates were identified. Of which, 18 (26.9%) isolates were detected as carbapenem-resistant. The most effective antibacterial agent was tigecycline (97%, 65 isolates) followed by imipenem and ertapenem (73.13%, 49 isolates). PCR showed that 13 isolates (19.4%) had blaNDM-1 gene and 5 (7.5%) harbored blaOXA-48. Examination of common capsular types showed that 2 isolates had K2 and 2 others had K54. REP-PCR revealed 10 clones and 11 singleton strains. MLST analysis of CRKP found ST15 as the most common type (13 isolates, 72.2%), but other STs were also detected namely, ST19, ST117, ST1390, and ST1594. ColE1 and IncL/M plasmids were the carriers of blaNDM-1 and blaOXA-48, respectively. The results showed that CRKP spread in our health centers. Our results, therefore, indicate a worrying trend of resistance to carbapenems in K. pneumoniae.
Comparative study of different meta-heuristics on optimal design of a heat exchanger
Authors: Jalghaf Humam Kareem , Askar Ali Habeeb , Albedran Hazim , Kovács Endre , Jármai Károly
Published: January 2023

The paper compares different metaheuristics for using heat exchangers as a benchmark to estimate the best design parameter values using optimization efficient algorithms. Many MATLAB algorithms are used in this study. Also, an engineering equation solver, which is commercial software, is used to solve the issue. The design calculates three variables, which are the length, and inner and outer pipe diameter of the heat exchanger. The results showed that the best algorithms are particle swarm optimization, and when using this algorithm, the optimal design of the double pipe heat exchanger is as follows: the pipe length is 5.6734·10−1 m, the pipe inner diameter is 8.0203·10−3 m, and the pipe outer diameter is 2.2439·10−2 m.
HUBUNGAN KEPEMIMPINAN KEPALA MADRASAH DENGAN CITRA LEMBAGA
Authors: Suryana Aep Tata , Kirana Zenda
Published: January 2023

A leader in educational institutions is often the attention of experts, in this case, especially with regard to the leadership of the head of the madrasa as the main person in charge of the existence of an educational institution, the problem in this study is how the leadership of the head of the madrasa in improving the good image of the institution in the eyes of the community. This study aims to determine the relationship between Madrasah Principal Leadership and Institutional Image at State Madrasahs in Sumedang Regency. This research method uses a quantitative approach with the type of correlational method. Based on the results of the study, it showed that the leadership of the Head of State Madrasahs in Sumedang Regency included very high qualifications, namely 4.26 in the interval range of 4.20 – 5.00. The image of the institution is included in the very high qualification of 4.29 which is found in the interval range of 4.20 - 5.00. The results obtained from the correlation of the significance of the relationship between the leadership of the madrasah principal and the image of the institution obtained 0.000. Therefore, the value of 0.000 <0.005 and the value of the correlation coefficient of 0.528 is in the interval value of 0.51 - 0.75, which means that the leadership of the madrasa head has a very strong relationship with the image of the institution. Then the coefficient of determination R Square 0.278 means that the contribution of the leadership variable of the madrasa principal to the image of the institution is 27.8%
Absolutization: The Source of Dogma, Repression, and Conflict
Authors: Ellis Robert M.
Published: January 2023

What do dogma, repression, and conflict have in common? They all result from human judgement blocked from wider understanding by a false assumption of completeness. This book puts forward a theory of absolutization, bringing together a multidisciplinary understanding of this central flaw in human judgement, and what we can do about it. This approach, drawing on Buddhist thought and practice, philosophy, psychology, neuroscience, embodied meaning, and systems theory, offers a rigorous introduction to absolutization as the central problem addressed in Middle Way Philosophy, which is a synthetic approach developed by the author over more than twenty years in a series of books. It challenges disciplinary boundaries as well as offering a substantial framework for practical application.
Caruso, Carlota (2022), 101 storie svelate. Le iscrizioni del Museo Nazionale Romano raccontano Roma. Dielle Editore, Villafranca di Verona, 225 páginas, ISBN: 978-88-9939-855-2.
Authors: Martínez-Sarasate Javier
Published: January 2023

Book Review
Czy Nowy Testament mógłby powstać bez Septuaginty?
Authors: Malina Artur
Published: January 2023

The New Testament texts depend on the Septuaginta translation for the grammar and vocabulary that they use. The influence is shown by the numerous quotations according to the most ancient translation of the Old Testament. The relationship between the two main parts of the Bible lies in the common content shared by the authors of their books. The present paper describes the dependence of the name “New Testament” on the Septuagint and demonstrates that its openness favored the reception of the Christian message.
Asociación entre los estilos de crianza y el rol de los adolescentes peruanos en el acoso escolar, 2019
Authors:   Universidad María Auxiliadora, Zegarra Chapoñan Roberto , Zeladita Huaman Jhon Alex , Cuba Sancho Juana Matilde , Castillo Parra Henry , Moran Paredes Gladys Ivonne , Cárdenas Niño Lucila
Published: January 2023

ntroducción. Los estilos de crianza determinan la conducta infantil; sin embargo, existe escasa información sobre su repercusión en el acoso escolar. Objetivo: Determinar la fuerza de asociación entre las diferentes tipologías de los estilos de crianza y el rol asumido en el acoso escolar, así como identificar perfiles de los adolescentes según su involucramiento en el acoso escolar. Materiales y métodos. Estudio transversal tipo analítico, realizado en Lima-Perú, en el año 2019. Se aplicó la escala de estilos de crianza de Steinberg y la escala EBIP-Q a 563 escolares de escuelas públicas. Los puntajes fueron obtenidos mediante un análisis factorial confirmatorio. Se empleó el coeficiente de correlación de Spearman, Chi Cuadrado de Pearson y análisis de regresión logística multinomial. Resultados. Existe asociación entre los estilos de crianza y el rol del adolescente en el acoso escolar. El análisis multivariado reportó que ser hombres se asocia con el rol de agresor (OR = 2,73); mientras que acceder a una red social (OR = 2,23), ser hombre (OR = 1,75), los estilos de crianza (negligente [OR = 2,72] y mixto [OR = 0,38] en comparación con autoritario) fueron predictores de asumir el rol de agresor victimizado en el acoso escolar. Discusión. La asociación encontrada en el estudio confirma hallazgos previos; sin embargo, se abre debate sobre la influencia del estilo de crianza negligente en la dinámica del acoso escolar. Conclusión. Tanto el estilo de crianza negligente y autoritario (menor proporción) tienen un efecto positivo y significativo en el rol de agresor victimizado.
Interim Analysis of Treatment Outcomes of Young Children with 5q Spinal Muscular Atrophy on Gene Replacement Therapy with Onasemnogene Abeparvovec. Clinical Observations
Authors: Kokorina Anna A. , Nikitin Sergei S.
Published: January 2023

Background. Onasemnogene abeparvovec is the first gene replacement therapy medication based on the adeno-associated viral vector (AAV9). One injection to a patient with 5q spinal muscular atrophy (SMA) leads to replacement of the missing or defective SMN1 gene with its functional copy. It leads to normalization of survival motor neuron protein (SMN) production.

Objective. The aim of the study is to evaluate efficacy, safety, and causes of different responses to therapy after single administration of onasemnogene abeparvovec in 5 patients with 5q SMA (types I and II) comparing the baseline status with the results of continued monitoring in real clinical practice in Russian Federation.

Methods. Interim results of continued follow-up of children with 5q SMA with 2–3 copies of the SMN2 gene are presented: 2 boys and 1 girl with type I who received single dose of onasemnogene abeparvovec at 4 and 7 months of age; and 2 girls with type II who received therapy at 11 and 16 months of age.

Results. Short-term controlled fever was observed in 4 out of 5 patients during first 2 weeks after viral vector therapy administration (max in patient 5 — up to 38.5 ° C). All 5 children had transaminases increase,  1 patient — significant transaminases increase during the sensitisation period (> 10 from upper normal level (UNL)), 1 patient — delayed significant transaminases increase (> 20 UNL), 1 patient — transaminases increase (> 3 UNL) after discontinuation of longterm therapy with glucocorticosteroids (according to prescribing information). All patients had shown positive and sustained response to therapy over time at motor status assessment via CHOP INTEND / HFMSE scales. The more significant response was observed in patients with less aggressive baseline 5q SMA type II with 3 copies of the SMN2 gene.

Conclusion. Onasemnogene abeparvovec is relatively safe medication for management of children with 5q SMA. Thus, the development of adverse events and their mechanisms should be further studied, as well as long-term follow-up of recipients is required to gather knowledge on this medication effects on human body.
Alfa-mannosidosis: Frequent Symptoms in Rare Patient
Authors: Vashakmadze Nato D. , Zhurkova Natalia V. , Mikhaylova Ludmila K. , Babaykina Marina A. , Karaseva Maria S. , Pashkova Kristina V. , Zakharova Ekaterina Yu. , Namazova-Baranova Leyla S.
Published: January 2023

Background. Alfa-mannosidosis is ultra-rare autosomal recessive lysosomal storage disease caused by the mutation in the MAN2B1 gene. Pathogenic nucleotide variants and structural changes in this gene lead to acid alpha-mannosidase deficiency, this enzyme is involved in oligosaccharides degradation. This disease is characterized by multisystem involvement and chronic progressive course.

Clinical case description. The clinical case attracted our attention due to the late disease diagnosis in a boy living in a metropolis. The child has classic clinical manifestations of the disease: typical phenotype, spinal deformity, developmental speech and motor delays, hearing loss, hepatomegaly, splenomegaly, umbilical and inguinal hernias. Despite developmental speech delay and frequent recurrent otitis, the patient has not been referred to surdologist examination until the age of 4.5 years. Intriguing fact is the presence of congenital cataract that was the reason for surgery twice.

Conclusion. Congenital cataract is one of the early manifestation of this disease. 3 out of 8 patients with alfa-mannosidosis observed in our centre had congenital cataract. We assume that such patients should be referred to genetics for the early exclusion of alpha-mannosidosis. Late diagnosis and progressive course of the disease led to early disability of the patient. Nowadays, as enzyme replacement therapy is available, it is crucial to identify these patients timely in order to improve their quality of life and increase survivability.
Mitochondrial Fatty Acid Beta-Oxidation Disorders in Children: Literature Review
Authors: Zhurkova Natalia V. , Vashakmadze Nato V. , Surkov Andrey N. , Smirnova Olga Ya. , Sergienko Natalia S. , Ovsyanik Natallia G. , Selimzyanova Lilia R.
Published: January 2023

Congenital mitochondrial fatty acid beta-oxidation disorders are a heterogeneous group of metabolic disorders characterized by impaired fatty acid metabolism in mitochondria. It results in central nervous system, skeletal muscle, cardiovascular system, and liver damage, as well as the development of nonketotic hypoglycemia. The age of disease manifestation and its severity range from severe (neonatal) to milder myopathic (adult) forms. The extension of the mass screening program in Russian Federation allows to detect these diseases during the first weeks of life. The availability of effective therapy for mitochondrial fatty acid beta-oxidation disorders, especially during early diagnosis, enables timely stabilization of the patient's condition and prevention of severe complications. Awareness of pediatricians, neonatologists, neurologists, and cardiologists about such diseases is the urgent task of modern pediatrics.
Druga fala kryzysu komunikacji politycznej w dobie mediatyzacji
Authors:   Uniwersytet Mikołaja Kopernika w Toruniu, Brodzińska-Mirowska Barbara
Published: January 2023

The deepening process of mediatization and the dynamic development of new technologies have perpetuated the phenomena that Blumler and Gurevitch called the crisis of public communication. Therefore, in my considerations, I present an argument supporting the thesis that we are currently observing premises for categorizing transformations in communication as the second wave of the crisis. The article is exploratory, epistemological in nature, and the considerations undertaken in it are focused on the main research problem related to determining what characterizes the second wave of the crisis of political communication.
Model budżetu obywatelskiego w Polsce – próba uporządkowania zagadnień teoretycznych
Authors:   Uniwersytet Śląski w Katowicach, Gnela Jakub
Published: January 2023

The term of a ‘model/models’ of the civic (participatory) budget (CB) has not been discussed more widely in the Polish literature so far. There are also no publications comparing the existing typologies or classifications. In the article, the author presents what the civic budget model is and its definition in political science research. Various approaches are presented based on both Polish and English-language literature on the subject. The main aim of the article is to propose a model of civic budget in Poland. For this purpose, the author presents practical solutions of the Polish CB and, on this basis, distinguishes between general models (based on the scale of the entire state) and specific models (based on the solutions in local government units). The author also presents the components of these general and specific models.
Górny Śląsk jako problem politologiczny. Próba syntezy
Authors:   Uniwersytet Śląski w Katowicach, Muś Anna
Published: January 2023

The growing body of scholarly literature on Silesians and Upper Silesia requires researchers to make first attempts to systematize the issue. The aim of this article is to demonstrate that in Upper Silesia we can observe unique, distinct political phenomena. The study was carried out as a structured review of scholarly literature which covers research in the field of political science, related to Silesians and Upper Silesia, treated as a specific object of analysis. The study included 25 scientific articles indexed in the Web of Science Core Collection database. The analysis has shown that many political phenomena occurring in Upper Silesia are of a unique character, not encountered in other regions of Poland. It also indicated a number of research problems that still need to be investigated and the problem of lack of data triangulation present in the literature.
Cele i założenia polityki Federacji Rosyjskiej wobec Białorusi w sferze naftowo-gazowej
Authors:   Uniwersytet Mikołaja Kopernika w Toruniu, Czwołek Arkadiusz
Published: January 2023

The aim of the article is to analyze the energy policy of the Russian Federation towards Belarus in 2015–2021. The article focuses on the issues of bilateral relations in the sphere of crude oil and natural gas. Russia uses energy tools towards Belarus in order to force it to deepen its political, economic and military integration. Russia also undertook the task of regulating the principles of further energy cooperation with Belarus.
Rosyjskie prywatne firmy wojskowe i ich rola w polityce wewnętrznej i zagranicznej
Authors:   Uniwersytet Mikołaja Kopernika w Toruniu, Olszanecka Natalia
Published: January 2023

Russia’s use of private military companies has strengthened in recent years, reflecting lessons learned from past actions, an expansive mindset and a desire for economic, geopolitical and military benefits. Military operations in Ukraine, starting from 2014, were one of the first tests for PMC. Since then, the Russians have perfected their model of operation. Even though the activities of private contractors are illegal under the Russian Constitution, they play an important role in pursuing Russian interests, mainly abroad. They weaken US influence and support Russia’s geopolitical, military and economic interests. They are present in as many as 30 countries on four continents. The purpose of this article is to define the role of Russian private military companies in the internal and external policy of the Russian Federation.
Kwestia tureckiego przystąpienia do II wojny światowej w polityce brytyjskiej między grudniem 1943 a styczniem 1944 r.
Authors:   Uniwersytet Łódzki, Zdulski Krzysztof
Published: January 2023

During the Cairo negotiations (December 4–7, 1942), the British, supported by the Americans, tried to persuade the Turks to make the air bases on their territory available to the Allies on February 14, 1944. This date was correlated with British preparations for attacking Rhodes as part of Operation Hercules. Throughout the rest of December and mid-January 1944, the British tried to convince the Ankara government to accept the terms of cooperation. The staff consultations which proceeded in early January highlighted the differences in the perception of the war situation by both sides, which eventually led to the breakdown of negotiations and the suspension of British military aid to Turkey. Nevertheless, the British government did not decide to break the treaty of mutual aid with the Turkey and this decision was influenced by political and military factors that was not directly related to the plans of capturing the Dodecanese.
Protesty społeczne a nierówności i zjawisko zawłaszczenia państwa w RPA
Authors:   Uniwersytet Wrocławski, Polus Andrzej , Kopiński Dominik ,   Uniwersytet Wrocławski
Published: January 2023

Abrupt social protests in South Africa, which erupted after the decision to jail the former president, Jacob Zuma, have stirred discussions on the ongoing state crisis and corruption of South African political elites. Meanwhile, these problems have deeper roots. The article argues that one of the main reasons of social unrest is a failure of a democratic state in enhancing social and economic opportunities of black South Africans and addressing the resultant increasing income and wealth inequalities. The article examines the context of the state’s erosion after it was monopolized by the African National Congress (ANC). Our arguments include the model of neopatrimonial state, related to the legacy of political transformation, but also to the departure of the ANC elites from its revolutionary ideals in favour of party loyalty. Another issue discussed in the article is a phenomenon called ‘state capture’.
Способ определения комплексного значения совокупных потерь полной мощности в системе электроснабжения
Authors: Ливенцов Вячеслав Сергеевич , Костинский Сергей Сергеевич , Троицкий Анатолий Иванович , Савелов Николай Семенович
Published: January 2023

Предложен способ расчета совокупных потерь в оборудовании системы электроснабжения, используемого для транспортировки электрической энергии, где учтены в целом совокупности элементов системы электроснабжения и нагрузки, связанные общим режимом работы, в отличие от известных способов, в которых потери рассчитываются отдельно по составляющим и по виду оборудования. В основу способа положена схема замещения системы электроснабжения, в которой для силового трехфазного двухобмоточного трансформатора использована приведенная симметричная Т-образная схема замещения одной фазы. Аналитически доказано, что рассмотрение вопросов, связанных с расчетом потерь в системе электроснабжения порознь в линии электропередачи и силовом двухобмоточном трансформаторе без учета их взаимного влияния друг на друга, приводит к неточности расчета. Выполнена оценка погрешности расчетов потерь и потребления полной мощности по предлагаемому способу в сравнении с математической моделью. Математическая модель разработана в программном комплексе Multisim. В качестве примера для выполнения расчетов принята система электроснабжения, состоящая из источника с номинальным напряжением 10 кВ + 10 %, линии электропередачи, выполненной трехжильным кабелем, силового трехфазного двухобмоточного трансформатора марки ТМГ11 номинальной мощностью 250 кВА и нагрузки. Расчетные значения, при использовании разработанного способа, практически совпадают с данными, полученными по итогам работы математической модели. Выполнен расчет суммарных потерь активной мощности, в принятой для математической модели системе электроснабжения, при расчете отдельно нагрузочных потерь в линии электропередачи и условно-постоянных и нагрузочных потерь в силовом трансформаторе. Относительная погрешность результатов расчета суммарных потерь активной мощности в этом случае составила 12,6 %. Доказано, что использование разработанного метода позволяет повысить точность расчета совокупных потерь и делает возможным выполнение дальнейших исследований, направленных на оценку влияния параметров питающей линии электропередачи, нагрузки и величины питающего напряжения сети на совокупные потери в оборудовании системы электроснабжения, используемого для транспортировки электрической энергии.
Multivariate Analysis of Variegated Expression in Neurons v1
Authors: M Shoenhard Hannah
Published: January 2023

Behavioral screens in model organisms have greatly facilitated the identification of genes and genetic pathways that regulate defined behaviors. Identifying the neural circuitry via which specific genes function to modify behavior remains a significant challenge in the field. Tissue- and cell type-specific knockout, knockdown, and rescue experiments serve this purpose, yet in zebrafish screening through dozens of candidate cell-type-specific and brain-region specific driver lines for their ability to rescue a mutant phenotype remains a bottleneck. Here we report on an alternative strategy that takes advantage of the variegation often present in Gal4-driven UAS lines to express a rescue construct in a neuronal tissue-specific and variegated manner. We developed and validated a computational pipeline that identifies specific brain regions where expression levels of the variegated rescue construct correlate with rescue of a mutant phenotype, indicating that gene expression levels in these regions may causally influence behavior. We termed this unbiased correlative approach Multivariate Analysis of Variegated Expression in Neurons (MAVEN). The MAVEN strategy advances the user’s capacity to quickly identify candidate brain regions where gene function may be relevant to a behavioral phenotype. This allows the user to skip or greatly reduce screening for rescue and proceed to experimental validation of candidate brain regions via genetically targeted approaches. MAVEN thus facilitates identification of brain regions in which specific genes function to regulate larval zebrafish behavior.
Disability and Social Inclusion: Lessons From the Pandemic
Authors: Barden Owen , Bê Ana , Prtichard Erin , Waite Laura
Published: January 2023

The coronavirus pandemic necessitated rapid, radical changes to global systems, structures, and organisations across all areas of life, including education, healthcare, and social services. These changes were something of a double‐edged sword. On the one hand, widespread adoption of the kinds of remote‐working technologies long advocated for by disabled people opened up possibilities for inclusion. On the other, some people’s inability to access such technologies, together with increased social isolation, exacerbated forms of exclusion. This thematic issue considers what lessons can be learned from the pandemic in striving to design a future which is more inclusive for all. In this editorial, we provide a brief overview of some of the major challenges the pandemic created for disabled people, who were disproportionately negatively affected by it. We also suggest that a disability rights lens is a useful way of highlighting both the contingency of disability and the need for more responsive and humane healthcare systems. The editorial goes on to outline the opportunities to challenge entrenched ableism and create a “new normal” the pandemic afforded. It concludes by offering a thematic overview of the articles in this thematic issue, which together reveal a complex pattern of inclusions and exclusions, interdependence, and intersectionality.
Towards Liveability in Historic Centres: Challenges and Enablers of Transformation in Two Latvian Towns
Authors: Vološina Margarita , Taurene Evija , Šķiņķis Pēteris
Published: January 2023

This article describes two Latvian towns, Cēsis and Bauska, which have medieval origins and noticeable layers of subsequent historic periods. Both of their town centres have historic heritage protection status and a complex mixture of values, needs, and opportunities for the locals and visitors. The towns have recently had some physical improvements implemented in their public spaces, with key differences in the interplay between local governments and stakeholders. The Cēsis case was a municipality-initiated and public-led intervention to build awareness. The Bauska case was mainly a plea from active inhabitants that was only partially realised by the municipality, with limited support. In both cases, the introduced changes tackled some accumulated challenges, such as insufficient walkability, degraded public space, and car-centric town centres, but they also provoked discussions about the quality of the achievements, which raised questions about collaboration culture and practice between stakeholders. This study evaluates the interventions initiated by the municipality and the initiatives by nongovernmental organisations from the point of view of the tools applied and from the point of view of the civil process. This research contributes to discussions about the challenges of different approaches in spatial planning and provides recommendations about possible integrated planning solutions, as well as about the formation of the civil process.
Recommendations for determining p values for aftershock sequences and catalogs
Authors: Nyffenegger Paul , Frohlich Cliff
Published: January 2023

Using synthetic aftershock sequences, we investigate the factors that influence the maximum likelihood estimate (MLE) of the Omori-law p value (pMLE) determined for aftershock sequences of individual earthquakes, as well as for “stacked” sequences constructed using aftershocks from two or more mainshock events. The estimated uncertainty in pMLE, called σMLE, depends explicitly on the aftershock sequence population N, the ratio of the begin and end times of the time interval of interest T/S, and on pMLE itself; this dependence on pMLE leads to over- or underestimating σMLE. Moreover, σMLE depends on the aftershock times themselves only as they affect pMLE and is unaffected by whether the sequence decay resembles the Omori decay model. Thus, we recommend that reported p values be accompanied by a goodness-of-fit test, such as the Anderson-Darling statistic Wn2, to assess how well the sequence resembles Omori's law (OL), as well as by values for N, S, and T. Stacking aftershock sequences permits the study of p values for entire catalogs as well as sequences possessing too few events to allow individual analysis. However, stacking sequences with differing begin and end times introduces artifacts into the aftershock time series that need to be avoided when determining p values. One artifact arising at small times after the mainshock mimics the effect of the c parameter in the modified Omori's law (MOL). We can avoid the artifacts by excluding time spans containing changes in the slope of the log rate of aftershock activity from the analysis. For most situations where sequences with varying p, N, and begin and end times are stacked, pMLE is approximately equal to the weighted mean of the individual sequence p values.
Making the most of the recordings from short-period seismometer arrays
Authors: Douglas Alan
Published: January 2023

Several methods have been developed for computing optimum multichannel filters for use with short-period arrays, but these methods are not widely used. The most commonly used method is delay and sum (DS) followed by high-pass filtering. This, however, fails to exploit fully the spatial-filtering properties of arrays, which if used should reduce the need for frequency filtering. To compute spatial filters requires the auto- and cross-correlation of functions of the noise. Here the correlation functions are specified using noise models rather than the observed noise in an interval (the fitting interval) preceding signal onset. With noise models, it is found that problems of signal distortion and “supergain” are avoided, supergain being excessive noise reduction in the fitting interval, with little reduction or even amplification of the noise outside the interval. Using minimum power (MP) filters, which minimize the noise at the output yet pass signals undistorted, it is shown using data from the 20-element array at Eskdalemuir, Scotland, that signal-to-noise improvements of up to 7 can be obtained during periods when noise levels are above average, the improvement with simple delay-and-sum processing for the same noise sample being only 1.7. The use of noise models allows stable and effective wave-number filters to be rapidly estimated and applied. For those seismograms for which the signal and noise after MP processing have obvious differences in predominant frequency, it is shown that optimum frequency filters can sometimes be used to further improve signal-to-noise ratio (S/N) without significant loss of bandwidth.
Seismic-reflection evidence that the Hayward fault extends into the lower crust of the San Francisco Bay area, California
Authors: Parsons Tom
Published: January 2023

This article presents deep seismic-reflection data from an experiment across San Francisco Peninsula in 1995 using large (125 to 500 kg) explosive sources. Shot gathers show a mostly nonreflective upper crust in both the Franciscan and Salinian terranes (juxtaposed across the San Andreas fault), an onset of weak lower-crustal reflectivity beginning at about 6-sec two-way travel time (TWTT) and bright southwest-dipping reflections between 11 and 13 sec TWTT. Previous studies have shown that the Moho in this area is no deeper than 25 km (∼8 to 9 sec TWTT). Three-dimensional reflection travel-time modeling of the 11 to 13 sec events from the shot gathers indicates that the bright events may be explained by reflectors 15 to 20 km into the upper mantle, northeast of the San Andreas fault. However, upper mantle reflections from these depths were not observed on marine-reflection profiles collected in San Francisco Bay, nor were they reported from a refraction prifile on San Francisco Peninsula. The most consistent interpretation of these events from 2D raytracing and 3D travel-time modeling is that they are out-of-plane reflections from a high-angle (dipping ∼70° to the southwest) impedance contrast in the lower crust that corresponds with the surface trace of the Hayward fault. These results suggest that the Hayward fault truncates the horizontal detachment fault suggested to be active beneath San Francisco Bay.
The Crisis of Liberal Democracy vs. Political Knowledge
Authors: Plecka Danuta
Published: January 2023

W powszechnej opinii demokracja liberalna przechodzi bardzo poważny kryzys. Poszukując jego źródeł wyróżnić można trzy płaszczyzny: ekonomiczną, polityczną i kulturową. Przy czym w debacie publicznej dość rzadko, poza postawieniem diagnozy o kryzysie demokracji liberalnej, prezentuje się możliwe metody jego przezwyciężenia. Tym samym zapomina się, że podstawą dla właściwego funkcjonowania demokracji liberalnej jest obywatel posiadający polityczne kompetencje. Bowiem tylko zaangażowany obywatel jest w stanie przezwyciężyć kryzysy występujące w demokracji liberalnej poprzez wykorzystanie wiedzy politycznej, działając w oparciu o wartości polityczne i rozwijając kulturę zaufania społecznego, przy zachowaniu zasady nieufności w rozumieniu liberalnym i demokratycznym. Polityczne kompetencje obywatelskie, jako podstawa postaw obywatelskich wspierających demokrację i respektujących jej zasady stanowią jeden z trzech filarów jej konsolidacji, a przez to także mogą się stać instrumentem przezwyciężania kryzysu demokracji liberalnej. Przy czym uznając równoważność komponentów politycznych kompetencji obywatelskich szczególną uwagę należy zwrócić na poziom wiedzy politycznej obywateli, bowiem to on determinuje ich kolejne elementy.
Prospective study of radiological and functional outcomes of humeral mid-shaft fractures by anterior bridge plating technique
Authors: Dey Joydeep Kumar , Shetty Sunil H. , Singh Shikhar Dalbir , Srivastava Abhilash , Agrawal Sarang , Modi Ravi Rajan , Jyoti Venkatesh , Gehlot Ojasv
Published: January 2023

Background: The humerus can be considered the most versatile bone in the human body. Can be successfully approached by a variety of methods for fracture fixation including functional bracing, plating (posterior, lateral, and anterior), and intramedullary nailing (antegrade and retrograde). Notably, many humeral fractures can be successfully managed conservatively due to the wide range of acceptability for reduction. Anterior bridge plating (ABP) which utilizes the minimally invasive approach popularly known as the minimally invasive percutaneous plate osteosynthesis (MIPPO) technique can be said to be the latest entrant in this list. The present study was undertaken to evaluate the efficacy of ABP.
Methods: The study was carried out from July 2020 to July 2022 in DR. D. Y. Patil medical college and hospital, Nerul, Navi Mumbai, involving 32 patients who met the selection criteria and were operated at the tertiary care centre. Informed consent was obtained from all the patients for use of their clinical and imaging data. Ethical committee approval was taken. The assessment of the patients was done based on functional and radiological outcomes periodically.
Results: Majority of patients belongs to age group 18-25 years (46.87%). Majority of side of injury were found right side (65.62%). In most of the cases, the extent of the displacement of fractures were 2-5 cm (71.87).
Conclusions: In conclusion ABP is a very good technique in treating mid-shaft humeral fractures with minimal soft tissue dissection, smaller scars, and early return to overhead activities.
A comparative analysis of pain reduction following a single intra-articular injection of platelet-rich plasma, steroid or normal saline in chronic external shoulder impingement syndrome
Authors: Shete Mohit R. , Popere Sanjay V. , Khan Rushan , Kulkarni Abhay P. , John James
Published: January 2023

Background: Shoulder impingement is a common diagnosis for patients with pain and dysfunction of shoulder joint. Due to its chronicity of clinical manifestation of the impingement syndrome, there is a need to find new therapies that collaborate to improve pain management.
Methods: A hospital based descriptive, epidemiological study was conducted with 150 patients. The patients were divided in the following three groups of 50 patients each: Platelet-rich plasma (PRP) group: 50 patients received PRP, steroid group: 50 patients received steroid injection normal saline group: 50 patients received normal saline injection. Baseline visual analogue scale (VAS) score on overhead activities were recorded. After the 4th week, 12th week, and 24th week, patients were examined in the outpatient clinic. The main outcome measure was pain with overhead activities using a VAS.
Results: The VAS score improved significantly in PRP group and Steroid group compared to normal saline group at the 4th week, 12th-week and 24th-week follow-up periods post injection, as per ANOVA test (p<0.05).
Conclusions: PRP and steroids, both can be considered effective methods to treat pain in chronic shoulder impingement syndrome (SIS) and less invasive compared to surgical treatment. They improve the pain and hence shoulder function in chronic impingement syndrome.
Impact of Recursive Feature Elimination with Cross-validation in Modeling the Spatial Distribution of Three Mosquito Species in Morocco
Authors: Douider Meriem , Amrani Ibrahim , Balenghien Thomas , Bennouna Amal , Abik Mounia
Published: January 2023

Many studies in ecology are interested in characterizing the ecological factors; determining the distribution of animal species. The classical approach consists in identifying the combination of ecological factors that allow reproducing observations of the presence and absence of the species of interest. The major difficulty lies in the imbalance between a considerable quantity of ecological factors to be tested and a relatively limited number of presence/absence observations. Selection of the most influential ecological features is a classical data pre-processing strategy that aims to overcome this imbalance and improve model performance. In this paper, we applied recursive feature elimination with cross-validation (RFECV) approach on presence/absence mosquito data in Morocco; to select optimal subsets of ecological features, in order to improve the performance of the predictive models. This method demonstrated the best ability to improve the performance of the predictive models, and can be recommended as a modeling improvement technique for large datasets.
DZ-OPINION: Algerian Dialect Opinion Analysis Model with Deep Learning Techniques
Authors: Bousmaha Kheira Zineb , Hamadouche Khaoula , Gourara Ismahane , Hadrich Lamia Belguith
Published: January 2023

Today, many sources of unstructured information such as social networks and blogs are more or less freely available on the web, and their volume is constantly growing, which constitutes a free gold mine for collecting public opinion. Opinion plays a crucial role because it can influence the decision-making process. Sentiment or opinion analysis is a discipline that can be used to meet decision-making needs, provide feedback to new product launches and marketing campaigns, and protect a company’s reputation, especially in social networking environments with massive data by exploiting textual data generated by users. In contrast to the techniques used, we have used and adapted in this study deep learning techniques: CNN and LSTM to identify their potential in this area and apply it to a corpus of Arabic data and in particular in Algerian dialect collected from social networks (50572 Facebook comments). We obtained promising results with an 85% f-measure. This represents a good start for an opinion analysis on the Algerian Dialect.
Shrimp Body Weight Estimation in Aquaculture Ponds Using Morphometric Features Based on Underwater Image Analysis and Machine Learning Approach
Authors: Setiawan Arif , Hadiyanto Hadiyanto , Widodo Catur E.
Published: January 2023

Shrimp is a marine culture found globally due to the ability of its yields to boost a country's economy. It is imperative to monitor its size to determine the condition of the shrimp underwater with complex noise using a non-invasive method. Therefore, this study aims to develop a new method for measuring the body weight of shrimp using morphometric features based on underwater image analysis and a machine learning approach. The method used consists of several steps, data collection using an underwater camera, image analysis using image grayscale, image binary, edge detection, region of interest detection, shrimp image morphometric features extraction, camera calibration using Triangle Similarity (TS), and Correction Factor (CF), calculation of morphometric features value, create machine learning model, training data, and testing data for estimation of underwater shrimp body weight. After testing the model, get the best accuracy value is RMSE = 0.05, MAE = 0.04, and R2 = 0.96 from the MLR method. In conclusion, the results showed that the hybrid method TS-CF-MLR is the best method for measuring underwater shrimp body weight estimation with the lowest error rate and highest coefficient of determination.
The effectiveness of amantadine and dalfampridine in improving fatigue in patients with multiple sclerosis: A randomized, double-blind, clinical trial
Authors: Sadeqi Yasaman , Baghbanian Seyed Mohammad , Bazi Aliyeh , Ghazaeian Monireh , Fallah Sahar
Published: January 2023

Background: Fatigue is a common complication associated with multiple sclerosis (MS). The aim of this study was to evaluate the impact of dalfampridine and amantadine on fatigue in patients with MS.
Methods: This was a randomized, double-blind, clinical trial on patients with MS. The recruited patients were adults (≥ 18 years old) diagnosed with MS; their Expanded Disability Status Scale (EDSS) was between 0.0 and 5.5, and their fatigue was confirmed by the Modified Fatigue Impact Scale (MFIS). They were randomly assigned to the amantadine (100 mg twice daily) and dalfampridine (10 mg twice daily) for eight weeks. The primary outcome was the improvement of fatigue score, and the secondary outcome was assessment of quality of life by the Short-Form Health Survey (SF-36) and any reported side effects.
Results: A total of 69 patients were recruited, and 54 of them were analyzed. The mean MFIS significantly improved in both groups after one and two months compared to baseline: amantadine: first month: 40.63 ± 14.35 (P = 0.040), second month: 36.56 ± 17.12 (P = 0.010); dalfampridine: first month: 38.29 ± 15.23 (P = 0.001), second month: 34.26 ± 18.30 (P = 0.001). However, the amount of changes from baseline was not significantly different (amantadine, P = 0.090; dalfampridine, P = 0.130). The amount of changes in quality of life showed no significant improvement (P = 0.210).
Conclusion: The results showed that dalfampridine was not different with amantadine in improving fatigue in patients with MS; besides, it showed an acceptable safety profile. Therefore, it can be considered as a possible beneficial therapeutic agent in MS fatigue.
Prognostic Value of the Expression of Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR-1) in Chronic Lymphocytic Leukemia
Authors: Yikilmaz Aysun Şentürk , Bakanay Şule Mine , Nurdan Avcı Duygu , Akinci Sema , Falay Mesude , Özet Gülsüm , Dilek İmdat
Published: January 2023

Background: The transmembrane receptor tyrosine kinase-like orphan receptor 1 (ROR1) has acted on the causation and sustentation of mature B cell lymphomagenesis for chronic lymphocytic leukemia (CLL) cells. The aim of this study was to show whether there is a relationship between the level of ROR1 surface expression in CLL cells and disease findings.
Materials and Methods: The level of ROR1 cell surface expression was determined in accordance with the flow cytometric analysis of CLL patients at the first diagnosis time.  2 groups were formed according to the high and low ROR1 levels. The cut-off point to the ROR1 level was calculated for advanced-stage disease by using receiver operating characteristic (ROC) curves. A two-sided p-value <0,05 was considered statistically significant.
Results: 108 CLL cases with a median age of 60 were enrolled. The median percentage of ROR1 cell surface marker positivity in the CD5/CD19 positive leukemic cell was 62%. The CLL cases with high ROR1 levels have thrombocytopenia (p=0.042), anemia (p=0.028), and high beta 2 microglobulin value ≥3 mg/dL (p=0.002) and the need for first-line treatment (p=0.043).
Conclusion: The poor prognostic parameters such as splenomegaly, anemia, higher beta 2 microglobulin levels, intermediate/advanced RAİ stage disease, and need for first-line treatment had associated high-level ROR 1 expression of our CLL patients. It needs to be investigated for its effect on predicting disease burden and aggressiveness with more comprehensive studies on ROR1 expression levels in CLL cases.
The Relationship between Smoking Status, Carbon Monoxide Levels and Quality of Life, Disease Characteristics in Inflammatory Bowel Diseases
Authors: KIRAÇ Yıldız , YALÇIN Bektaş , USTAOĞLU Müge
Published: January 2023

Objective: The aim of the study was to analyze the relationship between smoking status and exhaled carbon monoxide (E-CO) levels, quality of life, and disease characteristics in patients with inflammatory bowel disease. Methods: The demographic and disease characteristics and smoking status of 121 patients with inflammatory bowel disease who presented our hospital between 01.12.2020 and 01.03.2021 were investigated. After the first follow-up, the E-CO levels of these participants were measured every four consecutive weeks. The mean of these E-CO readings was accepted as the main E-CO value. After one month after their first application SF-36 Quality of Life Scale was applied. The relationship between these variables was investigated. Results: The mean age of the participants was 42.06±14.9 years, and 36.3% were active smokers. While patients with Crohn’s disease (CD) exhibited a higher smoking rate, smokers with ulcerative colitis (UC) registered significantly higher mean CO ppm readings (p<0.05). The general health components of smoker UC patients were higher than those of non-smokers (p<0.05). A weak correlation was determined between mean number of cigarettes smoked per day, mean CO ppm, Fagerström Nicotine Dependency Test (FNDT), package year, and the physical and mental components of SF-36 in the UC group (p<0.05). There was a weak negative correlation between mental components and mean E-CO in the CD group (p=0.027). No difference was observed in the non-smoker group between participants exposed to second-hand smoke and those with no such exposure (p>0.05). Conclusion: Our results revealed that smoking has a weak positive effect on the quality of health in patients with UC, but no effect on patients with CD.