bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Effective Voltage and Performance of Thermocells
Authors: Park Jonghak , Choe Younjeong , Kim Taewoo
Published: May 2023

Thermocells, also called thermogalvanic cells, are a promising technology that can efficiently harvest low-grade waste heat with direct thermoelectric conversion. The cells operate under a temperature difference, with one electrode on the hot side and the other on the cold side. The recently developed electrodes, such as porous carbon materials and pin-structured electrodes, have led to a temperature gradient even inside one of the electrodes. However, it still remains an open question of what temperature difference determines the open-circuit voltage of thermocells. Here, we investigated the effective voltage of a thermocell with thick electrodes. The temperature difference that determines the voltage turned out to be the smallest temperature difference between anode and cathode electrodes, the average temperature difference, or in between, depending on the internal resistances of the cell. We also verified the validity of normalized power density estimated from the open-circuit voltage. In addition, a strategy was demonstrated to improve the power density of a thermocell that consists of thick electrodes. The results provided here would help devise high-performance thermocells with optimized electrode structures.
Engineering of Conformal Electrode Coatings by Atomic Layer Deposition for Aqueous Na-ion Battery Electrodes
Authors: Staišiūnas Laurynas , Pilipavičius Jurgis , Tediashvili Davit , Juodkazytė Jurga , Vilčiauskas Linas
Published: May 2023

The application of atomic layer deposition on active material particles or as conformal layers directly on electrodes is an effective and viable approach for protecting the battery materials from degradation. Al2O3, TiO2, and HfO2 coatings are applied on NaTi2(PO4)3, which is among the most studied negative electrode materials for aqueous Na-ion batteries. The coated electrodes are characterized in terms of electrochemical kinetics, charge capacity retention, and electrochemical impedance spectra. Al2O3, a widely used protective coating in non-aqueous batteries, is shown to be insufficient to suppress parasitic processes and is eventually dissolved by reaction with hydroxide during extended cycling in aqueous Na2SO4. However, this process provides a local buffering effect making the protective action of this coating mainly of chemical nature. TiO2 is found to be very resistant to increase in pH and remains almost intact during electrochemical cycling. However, we provide strong evidence that TiO2 itself is electrochemically active in aqueous electrolytes at negative potentials. The protonation of TiO2 leads to an additional increase in local pH which is detrimental to NaTi2(PO4)3 and results in even faster capacity loss than in uncoated electrodes. Only HfO2 is found to be sufficiently stable and electrochemically inert ALD coating for negative NaTi2(PO4)3 electrodes operating in aqueous electrolytes.
Effects of Calcination Temperature Induced High-sensitivity N,N-dimethylformamide Gas-Sensing Performances Over LaFeO3Nanoparticles
Authors: Liang Shuang , Wu Dan-Dan , Zhang Hui-Ru , Liu Li-Ling , Huang Chu-Geng , Jiang Guo-Jian
Published: May 2023

Recently, field effect transistor type N,N-dimethylformamide (DMF) sensors have been widely studied, but semiconductor resistance type DMF gas sensors have not been reported much. Herein, porous LaFeO3nanoparticles were prepared by reverse co-precipitation, and the gas sensing detection performance of material was studied. The sensor based on LaFeO3calcined at 750 °C shows excellent response (Rg/Ra= 189.2), great selectivity and long-term stability to 100 ppm DMF at the operating temperature of 170 °C. The effects of different calcination temperatures (650 °C, 750 °C, 900 °C) on the structure and properties of LaFeO3were compared. The structural characterization data revealed that LaFeO3calcined at 750 °C has the appropriate specific surface area and abundant active sites, which plays a key role in promoting the adsorption and decomposition of target gas. In addition, the surface of the LaFeO3calcined at 750 °C has the highest concentration of adsorbed oxygen, which also provides an excellent condition for gas-sensitive reactions on the surface of the material. Therefore, LaFeO3is expected to be a potential novel material in DMF detection.
Hybrid Power Generation Supply Chain Financing and Purchasing Strategies with Option Hedging against Disruption
Authors: Dong Guoshu , Xia Qing , Xu Bo , Dong Ziguang
Published: May 2023

Environmental pollution has stimulated cleaner and sustainable energy (CSE) resource consumption which fuels low-carbon electric-power growth. This consumption is particularly affected by two factors. One of them is the power grid’s capital size in the electricity supply chain (ESC) and the other is the carbon emission reduction level elasticity of electricity consumption. Further, the financial strategy directly exerts quantifiable influence on one of the factors of capital size, while the procurement strategy plays a role in another factor. However, the impact of strategic behavior on all participants in the ESC remains unexplored. Thus, we construct a game model for the ESC consisting of two heterogeneous power plants and a strategic power grid with financial constraints, in order to analyze the purchasing and financing strategies for low-carbon electric-power consumption and examine the profit scenario from the credit and option hedging. We find that for the power grid, high self-owned funds level or affluent credit line encourages procurement. And when considering the power grid funds are uniformly distributed on or are constant, this funds property variation surely imposes influence on the wind electricity purchases. We find price elasticity of demand shows monotonic on the purchase when the power grid funds are constant but not necessarily when funds are uniformly distributed. The two power plants pursue the most favorable scenario for profit-maximizing by means of credit interest rate. Whether the power plants increase the financial credit interest is contingent upon option portfolios, the grid’s fund property, and wind yield conditions. We also find whether the relations between the two power plants are competitive or complementary depending on the wind yield rate. Numerical study shows that when the power grid funds are uniformly distributed, executing the double option seems to be the most profitable choice for the power grid and the traditional energy power plant, whereas with the uniform distribution of the grid’s funds, executing the call option but abandoning put is the most profitable to the traditional energy power plant. Moreover, under the grid’s fund of uniform distribution, it can both motivate power user consumption for clean energy generation and expand the power grid’s capital size.
Review on Physicochemical Modification of Biodegradable Plastic: Focus on Agar and Polyvinyl Alcohol (PVA)
Authors: Belay Mezigebu
Published: May 2023

Plastics materials which are used in our daily life especially for packaging applications are derived from petrochemicals. Though these plastic materials satisfy the required properties of packaging materials in terms of strength, water resistance, and durability, they are not biodegradable and stay in landfills for plenty of years. This causes serious environmental threat and pollution. Owing to this, biodegradable plastics have been emerged as an alternative to conventional plastics. However, most of the biodegrade plastics are dependent on forest reserves even some may affect food supply. Nevertheless, agar and polyvinyl alcohol (PVA) neither causes deforestation nor affect the food stock. Though agar and PVA neither causes deforestation nor affect the food supply, they have high water absorption and a moderate tensile strength. This restricts the use of these polymers for applications. Researchers have used physicochemical modification methods to improve the properties of biodegradable polymers with due attention of agar and PVA. This review presents the basics of polymers, biodegradable polymers, chemistry of biodegradation, environmental impacts of biodegradable polymers, and the physicochemical modification of biodegradable polymers with a special focus of agar and PVA.
Defending Privacy Inference Attacks to Federated Learning for Intelligent IoT with Parameter Compression
Authors: Zhu Yongsheng , Cao Hongbo , Ren Yuange , Wang Wanqi , Wang Bin , Hu Mingqing , Cai Baigen , Wang Wei
Published: May 2023

Federated learning has been popularly studied with people’s increasing awareness of privacy protection. It solves the problem of privacy leakage by its ability that allows many clients to train a collaborative model without uploading local data collected by Internet of Things (IoT) devices. However, there are still threats of privacy leakage in federated learning. The privacy inference attacks can reconstruct the privacy data of other clients based on GAN from the parameters in the process of iterations for global models. In this work, we are motivated to prevent GAN-based privacy inference attacks in federated learning. Inspired by the idea of gradient compression, we propose a defense method called Federated Learning Parameter Compression (FLPC) which can reduce the sharing of information for privacy protection. It prevents attackers from recovering the private information of victims while maintaining the accuracy of the global model. Extensive experimental results demonstrated that our method is effective in the prevention of GAN-based privacy inferring attacks. In addition, based on the experimental results, we propose a norm-based metric to assess the performance of privacy-preserving.
Data from iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-Cell RNAseq Data and Differentiate Cell Type–Specific Markers of Immune-Cell Infiltration
Authors: Turan Tolga , Kongpachith Sarah , Halliwill Kyle , McLaughlin Robert T. , Binnewies Mikhail , Reddy Dhemath , Zhao Xi , Mathew Rebecca , Ye Shiming , Jacob Howard J. , Samayoa Josue
Published: May 2023

Abstract
The development of immune checkpoint–based immunotherapies has been a major advancement in the treatment of cancer, with a subset of patients exhibiting durable clinical responses. A predictive biomarker for immunotherapy response is the pre-existing T-cell infiltration in the tumor immune microenvironment (TIME). Bulk transcriptomics–based approaches can quantify the degree of T-cell infiltration using deconvolution methods and identify additional markers of inflamed/cold cancers at the bulk level. However, bulk techniques are unable to identify biomarkers of individual cell types. Although single-cell RNA sequencing (scRNAseq) assays are now being used to profile the TIME, to our knowledge there is no method of identifying patients with a T-cell inflamed TIME from scRNAseq data. Here, we describe a method, iBRIDGE, which integrates reference bulk RNAseq data with the malignant subset of scRNAseq datasets to identify patients with a T-cell inflamed TIME. Utilizing two datasets with matched bulk data, we show iBRIDGE results correlated highly with bulk assessments (0.85 and 0.9 correlation coefficients). Using iBRIDGE, we identified markers of inflamed phenotypes in malignant cells, myeloid cells, and fibroblasts, establishing type I and type II interferon pathways as dominant signals, especially in malignant and myeloid cells, and finding the TGFβ-driven mesenchymal phenotype not only in fibroblasts but also in malignant cells. Besides relative classification, per-patient average iBRIDGE scores and independent RNAScope quantifications were utilized for threshold-based absolute classification. Moreover, iBRIDGE can be applied to in vitro grown cancer cell lines and can identify the cell lines that are adapted from inflamed/cold patient tumors.
Influencia del contexto en el desarrollo cognitivo infantil: revisión sistemática
Authors: Benítez María Angélica , Diaz-Abrahan Veronika , Justel Nadia R.
Published: May 2023

(analytical)Over the past few years, research has focused on the association between context and child development. One of the central problems addressed is whether a child's environment influences cognitive development. The context consists of different levels that interact with each other and influence people: the microsystem, mesosystem, exosystem and macrosystem. The goal of this systematic review is to investigate factors that form part of the context and affect child development. Twenty-two articles were selected through a search of empirical articles in indexed scientific journals. These were analyzed by comparing the variables used: population, country, evaluation instrument, evaluated construct, evaluation frequency and results. The results show that environmental factors belonging to each context level have the capacity to modulate child development.
Keywords: Environment; child development; cognition.
A representação dos refugiados da guerra Rússia-Ucrânia nos jornais portugueses
Authors: Oliveira Ana Rafaela Castro , Florêncio Andreia Filipa Marques , Silva Bruna Fabiana Monteiro da , Luís Daniela Inês Castro
Published: May 2023

A Guerra Rússia-Ucrânia provocou movimentos migratórios forçados por parte da população ucraniana, e nesse sentido, os media assumiram um papel importante na representação social destes refugiados. Com este artigo, pretendemos analisar como estes são representados nos jornais portugueses, nomeadamente, no Jornal de Notícias e no Público, durante o período de tempo de 7 de março a 21 de março, do ano 2022. A partir de uma análise de conteúdo, concluímos que os jornais os vêm principalmente como vítimas, onde os países se mostram disponíveis para o seu acolhimento e para a criação de condições que permitam o seu bem-estar, estando aqui presente a victimization frame. Foi-nos possível concluir que estes veículos de comunicação se referem a este tema, tendencialmente de forma positiva.
Systematic Electrophysiological Study Prior to Pulmonary Valve Replacement in Tetralogy of Fallot: A Prospective Multicenter Study
Authors: Waldmann Victor , Bessière Francis , Gardey Kevin , Bakloul Mohamed , Belli Emre , Bonnet Damien , Chaussade Anne-Solène , Cohen Sarah , Delasnerie Hubert , Dib Nabil , Di Filippo Sylvie , Dulac Arnaud , Hascoët Sébastien , Henaine Roland , Iserin Laurence , Karsenty Clément , Ladouceur Magalie , Legendre Antoine , Malekzadeh-Milani Sophie , Mostefa Kara Mansour , Radojevic Jelena , Ratsimandresy Miarisoa , Marijon Eloi , Maltret Alice , Khairy Paul , Combes Nicolas
Published: May 2023

Background:

Ventricular arrhythmias and sudden death are recognized complications in tetralogy of Fallot. Electrophysiological studies (EPS) before pulmonary valve replacement (PVR), the most common reintervention in tetralogy of Fallot, could potentially inform therapy to improve arrhythmic outcomes.

Methods:

A prospective multicenter study was conducted to systematically assess EPS with programmed ventricular stimulation in patients with tetralogy of Fallot referred for PVR from January 2020 to December 2021. A standardized stimulation protocol was used across all centers.

Results:

A total of 120 patients were enrolled, mean age 39.2±14.5 years, 53.3% males. Sustained ventricular tachycardia was induced in 27 (22.5%) patients. When identifiable, the critical isthmus most commonly implicated (ie, in 90.0%) was between the ventricular septal defect patch and pulmonary annulus. Factors independently associated with inducible ventricular tachycardia were history of atrial arrhythmia (odds ratio, 8.56 [95% CI, 2.43–34.73]) and pulmonary annulus diameter >26 mm (odds ratio, 5.05 [95% CI, 1.47–21.69]). The EPS led to a substantial change in management in 23 (19.2%) cases: 18 (15.0%) had catheter ablation, 3 (2.5%) surgical cryoablation during PVR, and 9 (7.5%) defibrillator implantation. Repeat EPS 5.1 (4.8–6.2) months after PVR was negative in 8 of 9 (88.9%) patients. No patient experienced a sustained ventricular arrhythmia during 13 (6.1–20.1) months of follow-up.

Conclusions:

Systematically performing programmed ventricular stimulation in patients with tetralogy of Fallot referred for PVR yields a high rate of inducible ventricular tachycardia and carries the potential to alter management. It remains to be determined whether a standardized treatment approach based on the results of EPS will translate into improved outcomes.

Registration:

URL:
https://clinicaltrials.gov/ct2/show/NCT04205461
; Unique identifier: NCT04205461
Systematic Review of Therapeutic Agents and Long-Term Outcomes of Familial Hyperaldosteronism Type 1
Authors: Tan Shu Ting , Boyle Veronica , Elston Marianne S.
Published: May 2023

Background:

Familial hyperaldosteronism type 1 (FH1), previously known as glucocorticoid-remediable aldosteronism, was the first identified monogenic cause of primary aldosteronism. Patients classically develop hypertension at a young age and are at risk of premature vascular complications. A systematic review of FH1 was performed to determine long-term treatment outcomes.

Methods:

Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted searches with a patient/population, intervention, comparison and outcomes (PICO) framework using Embase, Medline, PubMed, Scopus, and Web of Science databases to identify patients with FH1 prescribed either no treatment with a minimum 3 months follow-up or medical treatment of at least 3 months duration.

Results:

A total of 99 FH1 cases were identified from 42 studies. Most had early-onset hypertension but variable hypokalemia, hyperaldosteronism, and hyporeninemia. Of the 62 cases with a reported age of FH1 diagnosis, median age was 18 ± 17.6 years old. Of those treated, 72% received a glucocorticoid for long-term treatment compared with 22% receiving a potassium-sparing diuretic. Data on long-term treatment and disease side effects, complications, and outcomes were seldom reported. However, of 20 patients with reported complications, premature vascular complications were evident with the median age of diagnosis for left ventricular hypertrophy and hypertensive retinopathy 15 and 16.5 years old respectively, the youngest age of aortic dissection age 10 years, and those with reported cerebrovascular history had strokes or transient ischemic attacks before age 40 years.

Conclusions:

Major gaps in the literature around FH1 patients’ long-term treatment and disease outcomes still exist. Long-term outcome data are required to help inform clinicians of the best long-term treatment for FH1.
A Traveling Waves Perspective on Temporal Binding
Authors: Alamia Andrea , VanRullen Rufin
Published: May 2023

Brain oscillations are involved in many cognitive processes, and several studies have investigated their role in cognition. In particular, the phase of certain oscillations has been related to temporal binding and integration processes, with some authors arguing that perception could be an inherently rhythmic process. However, previous research on oscillations mostly overlooked their spatial component: how oscillations propagate through the brain as traveling waves, with systematic phase delays between brain regions. Here, we argue that interpreting oscillations as traveling waves is a useful paradigm shift to understand their role in temporal binding and address controversial results. After a brief definition of traveling waves, we propose an original view on temporal integration that considers this new perspective. We first focus on cortical dynamics, then speculate about the role of thalamic nuclei in modulating the waves, and on the possible consequences for rhythmic temporal binding. In conclusion, we highlight the importance of considering oscillations as traveling waves when investigating their role in cognitive functions.
CONSCIOUS SELF-REGULATION AS RESOURCE FOR OVERCOMING STRESS AND ACHIEVING SUBJECTIVE WELL-BEING: ETHNOREGIONAL SPECIFICITY
Authors: Banshchikova Tatiana N. , Sokolovskii Maksim L. , Tegetaeva Janna R.
Published: May 2023

Background. Th e problem of maintaining subjective well-being in situations of uncertainty becomes extremely relevant in the context of the global challenges of modern society. Th e signifi cant role of conscious self-regulation (SR) in achieving subjective well-being has been shown in samples of students at various levels of education, but has not yet been considered in samples of young people from various ethno-regional groups. Th e study of cross-cultural aspects of SR infl uence on subjective well-being in conditions of uncertainty is intended to supplement this section of psychological knowledge and is in demand by modern psychological practice in the regions characterized by ethnocultural diversity. Objective. Th e study had its purpose to reveal ethno-regional specifi cs in the relationship of conscious self-regulation, tolerance to uncertainty, levels of stress, aggression, and subjective well-being. Methods. The diagnostic complex included V.I. Morosanova’s questionnaire “Style of self-regulation of behavior, SSPM-2020”, the questionnaire for diagnosing the subjective well-being of a person by R.M. Shamionov, T.V. Beskova; the questionnaire of tolerance / intolerance to uncertainty by T.V. Kornilova and M.A. Chumakova, the q uestionnaire of perceived stress by T. Young, the questionnaire for diagnosing aggression by S.N. Enikolopov, N.P. Tsibulsky. Sample. Th e study involved 1099 respondents aged 16 to 35 years (679 women) from the Karachay-Circassian Republic, the Kabardino-Balkarian Republic, the Republic of North Ossetia-Alania, the Stavropol Territory, Moscow and the Moscow Region. Results. A path analysis of the connection between conscious self-regulation and subjective well-being was carried out for 7 ethno-regional groups of respondents. Th is allowed for establishing both direct and indirect (through reduction of stress and aggression) eff ect of the SR component “persistence” on the subjective well-being of participants. Along with general patterns, the study revealed the ethno-regional specifi city of the resource role of conscious SR in achieving subjective well-being. For the dominant ethnic groups, SR components “modeling”, “persistence”, and “reliability” serve as the resources of subjective well-being. Intolerance to uncertainty turned toь be a predictor of their subjective well-being. For the non-dominant ethnic groups, SR components “planning”, “persistence”, and “reliability” serve as the resources of subjective well-being. Tolerance to uncertainty is predicting their subjective well-being. Conclusion. Th e study provides empirical evidence of the direct and indirect influence of the conscious SR components on the level of subjective well-being of the young people in various ethno-regional groups.
FEELING OF SAFETY AND PERCEIVED BASIC EMOTIONS: EXPERIMENTAL EYE TRACKING STUDY
Authors: Bubnovskaia Olesia V. , Chemerskoy Grigory S. , Bodur Vladimir D.
Published: May 2023

Background. Th e relevance of the study is determined by the need to understand emotional aspects of safety and psychophysiological mechanisms underlying it, which are signifi cant for the development of resources for its self-provision. Objective. To analyze the relationship between the feeling of safety and perceived basic emotions, taking into account diff erent ways of presenting stimulus material, as well as individual and gender diff erences. Methods. Th e study implemented the oculography method (eye tracking), paired comparisons, the “EmIn” test measuring emotional intelligence, the TIPI-RU personality questionnaire, comparative and correlation analysis. Sample. Th e study involved students and staff of the Far Eastern Federal University (N = 13, mean age 26.5 years), the database included 819 measurement procedures. Results. Joy and anger are the most signifi cant emotions for a person’s sense of safety and are associated with individual and gender diff erences established during the study depending on the ways of presenting stimulus material. Th e study revealed the predominance of gaze fi xations in the subjects of both sexes on the female faces, on the emotional expressions of anger, fear (on women faces) and joy (on men faces). Correlation analysis established closer connections of the sense of safety with emotions of calmness, joy and disgust, less pronounced connections — with emotions of surprise and fear. Although when perceiving both photographs of faces and descriptions of emotions the largest number of choices were made in favor of positive emotions as the safest ones, analysis of physiological reactions revealed a predominance of gaze fi xations on the negative emotions as well. Conclusion. A person can associate with a sense of safety not only positive and neutral emotions but also the negative ones. Th e most security-threatening emotions are disgust and anger, the safest ones are joy, calmness and surprise (for women — mostly joy, for men — calmness). Compared to men, women rate sadness and disgust as safer emotions, while anger and fear — as less safe. Attribution of emotions as associated with safety is correlated with high scores on the “openness”, “emotional stability” and “emotional intelligence”. Th e results obtained contribute to the study of the emotion recognition mechanism, taking into account the ways of stimulus prese ntation, to the study of the psychophysiological aspects of the safety perception, and can be used in the development of tools for training emotional intelligence.
Bringing Bonhoeffer into Dialogue with Schmitt in Contemporary China
Authors: Lam Jason
Published: May 2023

Since the 2000s there has been a group of prominent scholars in China embracing the political views of Carl Schmitt. They are aware of the dangerous side of his thought but have provided reasonable analysis in relation to the Chinese social situation. Outlining their discussions, this article will depict the phenomenon with a focus on Schmitt’s controversial political theology. That will be compared with the thought of Dietrich Bonhoeffer. Although their political alignments were opposed to each other, the theoretical structure of their thinking reveals striking similarities. This article will thus articulate the theological reasons that allow for the differences between their ideas and actions and will produce a reflection on the contemporary situation in China. It is not due to the theoretical structure, but to the image of the sovereign embraced, that the stances of the two thinkers differed. From this we may draw implications from a public theological discussion for constructing a democratic society in the context of China.
The Evolving Role of the General Assembly vis-à-vis the Security Council in the Maintenance of Peace
Authors: Barber Rebecca
Published: May 2023

In recent years, the UN Security Council has proved unable to respond to pressing global security crises. The General Assembly has been stepping up, passing robust resolutions including on Syria, Myanmar and Russia/Ukraine, and most recently committing to meet every time a veto is cast in the Security Council.

This article considers whether the Assembly’s recent interventions have altered its position in the UN system vis-à-vis that of the Security Council. It first reviews the Assembly’s powers as described in the UN Charter, then reviews the Assembly’s evolving practice, and then elaborates how, legally, that practice shapes the Assembly’s competence. The article concludes that the Assembly’s recent interventions have not further expanded its powers, but have shifted the status quo pertaining to the relative roles of the General Assembly and Security Council. The final part of the article proceeds on the assumption that we may now look to the Assembly to intervene more routinely in global crises, and considers what we should thus look to the Assembly to usefully do.
Designing Photoelectric Sensor Module in Infrared Communication and Applying Wireless Sensor Network in Leakage Cable Detection
Authors: Xie Xinhui
Published: May 2023

With technological advancement, Near-infrared (NIR) spectroscopy instruments have gradually entered people’s daily life and production with their unique performance. Therefore, it has a positive significance in researching NIR spectroscopy analysis technology. This work designs
a refrigerating Lead Sulfide (PbS) NIR photoelectric sensor P2664-05 and its photoelectric signal conversion circuit. The converted voltage signal is used for subsequent circuit processing through the amplification and frequency selection circuit. The aim is to ensure the sensor’s corresponding
detectable spectral wavelength, sensitivity, and signal-to-noise ratio are improved under low temperatures. To this end, the refrigeration current generation circuit is designed. The refrigerating temperature is set below −15 °C, and the refrigerating current is 500 mA. At the same
time, it is necessary to monitor whether the sensor’s temperature state meets the system stability requirements during the refrigeration process. The designed sensor module is connected to the instrument system in the test, and the whiteboard without spectral absorption is scanned. The
results show that the designed NIR sensor’s shortcomings in noise processing performance have been improved using a System on a Programmable Chip (SoPC) as a processor. An infrared communication node is designed using its built-in digital resources and TFDU infrared communication chip.
The designed NIR sensor and communication node are added to the 485 bus to build a communication network. In leakage cable detection, the communication network has higher security, lower error rate, and lower power consumption.
Low-Power and High-Precision Readout Circuit Design for Micro-Electromechanical Systems (MEMS) Acceleration Sensors
Authors: Zhang Kai , Li Ting , Li Haisong , He Jie , Xu Weidong
Published: May 2023

MEMS acceleration sensors are widely used in Internet of Things, electronic machinery, aerospace and other fields with outstanding advantages such as small size, high reliability, intelligence and high integration. Traditional MEMS acceleration sensors limit their applications due to
high-power consumption and low-precision; the standby time and service life are being increased in order to study the low-power and high-precision MEMS acceleration sensor readout, this paper adopts the Fully Differential Switched Capacitor-Variable Gain Amplifier (FDSC-VGA) instead of the
traditional high-power Capacitance-to-Voltage Converter (CVC-VGA), Sample-and-Hold Circuit (S&H) and Anti-Aliasing Filter (AAF) as front-end modules. At the same time, a high-precision four-phase non-crossover clock is designed to precisely control the timing switch, thus effectively reducing
the power consumption of the MEMS acceleration sensor readout circuit; then, the overall readout circuit is simulated and verified by Dong Bu HiTek 0.18 μm process. The results show that the error rate of the output voltage of FDSC-VGA is reduced from 8.03% to 0.88% compared with
the conventional readout circuit, and the noise power consumption of MEMS acceleration sensor readout circuit can be reduced by 65%.
Treatment activity of hydrogels loaded with copper metal–organic frameworks of dacarbazine on melanoma by modulating melanoma prognostic markers S100A6 and VEGFa
Authors: Gao Fei , Liu Linbo , Li Lei , Li Guangshuai , Zhan Wang , You Wenjian , Lin Xia , Liu Yun , Wang Jiayao , Zhang Jianan , Chen Denglin
Published: May 2023

In the present paper, a new Cu(II)-based coordination polymer (CP) with the chemical composition of [Cu2(μ4btca)(phen)2(H2O)2]n (1) was synthesized and successfully loaded with the drug dacarbazine.
Based on the chemical synthesis method, HA/CMCS hydrogels loaded with copper metal–organic frameworks of dacarbazine were prepared. SEM results showed the hydrogels had a typical macroporous structure with good penetration between the pores. The results of the CCK-8 assay showed the
hydrogels could substantially reduce the viability of the melanoma cells. In addition, the hydrogels reduced the migration and invasive ability of cancer cells in a dose-dependent manner by suppressing the expression of melanoma prognostic markers VEGFa and S100A6, which
is a promising application for the treatment of melanoma.
Dual-source CT with metal sphere-tube for preoperative evaluation of patients with aortic valve disease treated by transcatheter aortic valve implantation
Authors: Liu Bin , Hu Jian , Jiang Yue , Zhou Zhongchun , Liu Fei , Liu Xingrui , Hou Huadong , Sun Guifang
Published: May 2023

To predict the effects of Dual-source CT imaging technology for preoperative patients with transcatheter aortic valve implantation. This is a parallel, randomly allocated to following two groups: patients with the Dual-source CT imaging technology and with conventional imaging technology,
and the clinical material from two groups patients with Aortic valve disease are collected, and the images quality between two group are assessed and then complications in one month after surgery are recorded by follow-up. Our outcomes show that patients by the Dual-source CT imaging technology
show less complications compared to patients by conventional imaging technology and imaging quality is better than that in conventional imaging group. In addition, image noise, and contrast-to-noise ratio are also examined by Dual-source CT imaging. We can conclude that the Dual-source CT
can effectively reduce the complications, and the Dual-source CT can predict effects of preoperative patients with Aortic valve disease and prevent the development of Aortic valve disease (AVD).
Preparation of a composite-based thin film and its sensing application for detecting beef freshness
Authors: Fu Ruimin , Zhang Hong , Liu Chunlei , Yu Feng , Wang Ding , Chen Wuling
Published: May 2023

In order to improve the stability of polyphenols anthocyanidins as freshness indicator in food packaging, in this study, gellan (GL), grape-skin anthocyanidins (GSAC) and chitosan-polyvinyl alcohol (CHPA) were prepared as a composite film to protect beef and indicate the beef freshness
for visual detection. The results indicated that the composite film appears good mechanical properties. The results of scanning electron microscopy showed that when the composite film were added into CHPA, the structure compatibility and stability of the film was the best. Then the complicate
film was used to indicate the beef freshness and the beef was stored at 4 °C, the total volatile base nitrogen content of beef had increased continuously with the extension of storage time. After 6 days, the total volatile base nitrogen content was 35.65 mg/100 g, the thiobarbituric acid
reaction product value was 1.005 mg, and pH value was 6.96. It can be seen directly with the naked eyes that the color of the film changed from dark red to mauve, and finally to blue brown, suggesting that the beef had been rotten. To sum up, the composite film made up of CHPA and gellan (GL)
anthocyanin (AC) can not only reduce the oxidation of anthocyanin and improve its stability, but also be used as an indicator of meat freshness.
Working-Class Women and the Progressive Era Development of Public Administration: The Case of Margaret Bondfield
Authors: Schachter Hindy Lauer
Published: May 2023

Using a case study of British trade union organizer Margaret Bondfield, this article begins the task of adding a working class perspective to accounts of women’s participation in Progressive era urban reform and expansion of public policy while also showing how international networks of support among trade union women undergirded American reform efforts. The narrative expands the consideration of intersectionality and positionality in analyzing women’s role in developing public administration.
Doing the work: Locating labour in infrastructural geography
Authors: Stokes Kathleen , De Coss-Corzo Alejandro
Published: May 2023

As the social sciences undergo an infrastructural turn, geographers have taken steps to broaden, disrupt, and reconceptualise understandings of infrastructure and its relationship to social, political, economic, and ecological processes. We contribute to this discussion by highlighting the emergence of a comparatively understudied yet crucial aspect within infrastructural geographies – infrastructural labour. We identify key theoretical anchors that guide contemporary analyses of infrastructural labour, which we query by focusing on five key areas of scholarly discussion. Building on these, we offer a working definition of infrastructural labour to help guide further engagement and point to questions meriting additional investigation.
Crying Wolf: A Qualitative Review of Misinformation and Conspiracy Theories in Lupus Erythematosus
Authors: Porter Emma , Murphy Michelle , O’Connor Cathal
Published: May 2023

Background

Lupus comprises a complex group of inflammatory disorders including cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). The issue of health misinformation is increasingly problematic, although the content of misinformation related to lupus available online has not been deeply explored. This study aimed to qualitatively assess the type of misinformation related to lupus available online.

Methods

A literature search on PubMed was conducted, using search terms “cutaneous lupus” OR “discoid lupus” OR “lupus” AND “misinformation” OR “conspiracy” OR “disinformation.” Further searches were also performed on Google, YouTube, Twitter, Facebook, Instagram, and TikTok.

Results

Published literature describing lupus-related misinformation was minimal, with only three manuscripts identified. Conversely, a variety of points of misinformation were identified online and on social media. Key themes identified in online content included suggestion of incorrect causes such as infection or aspartame consumption, false risk assessments such as lupus never developing in males, false claims about conventional treatments, and promotion of alternative treatments or “cures” without evidence.

Conclusion

Dermatologists, rheumatologists, and all clinicians treating patients with lupus play an essential role in dispelling the pervasive misinformation surrounding the disease and its treatments, encouraging patients to seek reliable sources of information, and advocating for evidence-based guidance.
Tensor decomposition for modified quasi-linear viscoelastic models: Towards a fully non-linear theory
Authors: Balbi Valentina , Shearer Tom , Parnell William J
Published: May 2023

We discuss the decomposition of the tensorial relaxation function for isotropic and transversely isotropic (TI) modified quasi-linear viscoelastic (MQLV) models. We show how to formulate the constitutive equation using a convenient decomposition of the relaxation tensor into scalar components and tensorial bases. We show that the bases must be symmetrically additive, i.e., they must sum up to the symmetric fourth-order identity tensor. This is a fundamental property both for isotropic and anisotropic bases that ensures the constitutive equation is consistent with the elastic limit. We provide two robust methods to obtain such bases. Furthermore, we show that, in the TI case, the bases are naturally deformation-dependent for deformation modes that induce rotation or stretching of the fibres. Therefore, the MQLV framework allows to capture the non-linear phenomenon of strain-dependent relaxation, which has always been a criticised limitation of the original quasi-linear viscoelastic theory. We illustrate this intrinsic non-linear feature, unique to the MQLV model, with two examples (uni-axial extension and perpendicular shear).
Non-perfusion severity correlates with central macular thickness and microvascular impairment in branch retinal vein occlusions
Authors: Antropoli Alessio , Bianco Lorenzo , Arrigo Alessandro , Bandello Francesco , Battaglia Parodi Maurizio
Published: May 2023

Purpose

To study peripheral capillary non-perfusion (PCN-P) in branch retinal vein occlusion (BRVO) by means of ultra wide-field fluorescein angiography (UWFFA), and to correlate its extent and severity with optical coherence tomography (OCT) and OCT-angiography (OCTA) parameters and best corrected visual acuity (BCVA).

Methods

Prospective case series with 2 years of planned follow-up. We recruited patients from June 2019 to December 2019. Ophthalmologic examination included BCVA, UWFFA, OCT and OCTA. Partial (p) and complete (c) ischemic index (ISI) were evaluated on UWFFA images. Vessel density (VD) in both the macular region and the optic nerve head (ONH) was calculated.

Results

Twelve BRVO subjects and 12 healthy controls were recruited. Mean age was 63.8  ±  8.74 years. Mean BCVA improved from 0.43  ±  0.25 logMAR to 0.15  ±  0.18 after two years (p < 0.01), while mean central macular thickness (CMT) decreased from 463.83  ±  200.85 µm to 353.17  ±  108.85 µm (p > 0.05). Mean cISI, pISI and total ISI were 25.2  ±  13.0%, 6.3  ±  5.0% and 31.5  ±  12.0%, respectively. Except for VDs of the superficial capillary plexus and choriocapillaris in the macular region, all VDs were lower in the BRVO group (p < 0.01). cISI and tISI negatively correlated with mDCP (p < 0.01), whereas only pISI correlated with CMT at baseline (p < 0.05). Additionally, cISI also negatively correlated with VD at the ONH (p < 0.05).

Conclusion

The amount of complete and partial ischemia may have different implications in BRVO, with the former being more associated with microvascular impairment and the latter with macular edema.
Investigating digitally mediated temporal experience: From empiricism to ethics
Authors: Markham Tim
Published: May 2023

Much recent scholarship in the field of media phenomenology has investigated the role of temporality in shaping our experience of digital media in everyday life, as well as the ethical and political ramifications that flow from it. Consistent with the central phenomenological tenet of locating the present as ontologically prior to any past origin, the idea is that in order to properly understand the texture of day-to-day digital navigation our focus should not be on discrete media texts or objects, but on the way they are experienced first and foremost as presents into which we find ourselves repeatedly thrown. The aim of this article is to establish an empirical framework for scrutinizing the ethical dimensions of digitally mediated temporal experience. The traces of this experience are not paths from a past or causal origin, but traces of mobility experienced as always-already presentness.
Assessment of patients with painful joints
Authors: Locke Corinne
Published: May 2023

Joint pain makes up a significant proportion of presentations to general practice. Causes range from minor mechanical issues to serious conditions such as septic arthritis. Clues from the history such as onset, progression, and extra-articular symptoms aid diagnosis. Many cases of joint pain are appropriately investigated and managed in general practice, but some presentations require referral to secondary care, such as those with signs or symptoms of inflammatory arthritis. It is crucial that red flags for serious or life-threatening causes of joint pain are identified and acted upon urgently.
Parents’ expectation of antibiotic prescriptions for respiratory infections in children: a systematic review and meta-analysis
Authors: Shamim Muhammad Aaqib , Padhi Bijaya K. , Satapathy Prakasini , Siddiq Abdelmonem , Manna Subhanwita , Aggarwal Arun K. , Al-Ahdal Tareq , Khubchandani Jagdish , Henao-Martinez Andrés F. , Sah Ranjit
Published: May 2023

Objectives:

Despite most childhood infections being self-limiting, children are among the leading consumers of antibiotics. Little is known about parental expectations of antibiotics for childhood infections. A comprehensive systematic review and meta-analysis was conducted to explore the nature and extent of parental expectations of antibiotic prescriptions for children with respiratory infections.

Design:

Systematic review and meta-analysis.

Methods:

An extensive literature search using six major scientific databases was conducted for all published articles until 7 December 2022. Primary studies reporting parents’ expectations of antibiotics for children with upper respiratory tract infections were included after assessment for quality. Heterogeneity between the studies was assessed using the I2 statistic and publication bias was analyzed using funnel plots and Egger regression tests. The primary outcome was a summary estimate of the percentage of parents who expect antibiotics from their physicians when their child presents with an upper respiratory tract infection.

Results:

From a total of 4510 studies found in the initial searches, a final pool of 19 eligible studies with 15,664 individuals was included in this meta-analysis. Nine of the 19 studies were from the United States or Saudi Arabia. The pooled prevalence of parental expectations of antibiotics in the population reviewed was 55.78% (95% CI = 44.60–66.41). There was significant heterogeneity between the studies, but funnel plot and meta-regression did not detect any publication bias.

Conclusion:

More than half of parents expect antibiotics for their children during consultation for upper respiratory tract infections. Such practices may cause undue side effects among children, contribute to the growing burden of antibiotic resistance, and lead to treatment failure for many common infections in the future. To optimize efforts to tackle antimicrobial resistance, shared decision-making and education emphasizing the proper and judicious use of antibiotics are much needed in pediatric healthcare settings. This can also help to manage parents’ expectations when seeking antibiotics for their children. Despite pressure from parents, pediatric healthcare providers should continue to advocate for antibiotic use only when warranted and help improve knowledge and awareness amongst parents.

Registration:

The protocol has been registered with PROSPERO (CRD42022364198)
The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia
Authors: Chang Yunchao , Keramatnia Fatemeh , Ghate Pankaj S. , Nishiguchi Gisele , Gao Qingsong , Iacobucci Ilaria , Yang Lei , Chepyala Divyabharathi , Mishra Ashutosh , High Anthony A. , Goto Hiroaki , Akahane Koshi , Peng Junmin , Yang Jun J. , Fischer Marcus , Rankovic Zoran , Mullighan Charles G.
Published: May 2023

Advancing cure rates for high-risk acute lymphoblastic leukemia (ALL) has been limited by the lack of agents that effectively kill leukemic cells, sparing normal hematopoietic tissue. Molecular glues direct the ubiquitin ligase cellular machinery to target neosubstrates for protein degradation. We developed a novel cereblon modulator, SJ6986, that exhibits potent and selective degradation of GSPT1 and GSPT2 and cytotoxic activity against childhood cancer cell lines. Here, we report in vitro and in vivo testing of the activity of this agent in a panel of ALL cell lines and xenografts. SJ6986 exhibited similar cytotoxicity to the previously described GSPT1 degrader CC-90009 in a panel of leukemia cell lines in vitro, resulting in apoptosis and perturbation of cell cycle progression. SJ6986 was more effective than CC-90009 in suppressing leukemic cell growth in vivo, partly attributable to favorable pharmacokinetic properties, and did not significantly impair differentiation of human CD34+ cells ex vivo. Genome-wide CRISPR/Cas9 screening of ALL cell lines treated with SJ6986 confirmed that components of the CRL4CRBN complex, associated adaptors, regulators, and effectors were integral in mediating the action of SJ6986. SJ6986 is a potent, selective, orally bioavailable GSPT1/2 degrader that shows broad antileukemic activity and has potential for clinical development.