bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic value of circulating miR-155 for breast cancer: a meta-analysis
Authors: Wang Fang , Wang Jin , Zhang Hongjiang , Fu Baobao , Zhang Yanshun , Jia Qianqian , Wang Yong
Published: March 2024

Backgrounds

The value of circulating microRNA (miR)-155 for breast cancer (BC) diagnosis may differ in different studies. Therefore, we conducted this systematic review and meta-analysis to evaluate the potential application of circulating miR-155 in the diagnosis of BC.

Methods

Articles published before December 2023 and in English were searched in these databases: PubMed, Web of Science, Medline, EMBASE and Google Scholar. A summary of sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratio (DOR) were calculated from the true positive (TP), true negative (TN), false positive (FP) and false negative (FN) of each study. Additionally, the summary receive-operating characteristics (SROC) curve was constructed to summarize the TP and FP rates.

Results

The pooled parameters calculated were as follows: sensitivity, 0.93 (95% CI: 0.83-0.97); specificity, 0.85 (95% CI: 0.74-0.92); PLR, 6.4 (95% CI: 3.4-11.9); NLR, 0.09 (95% CI: 0.04-0.20); and DOR, 74 (95% CI: 22-247). The analysis showed a significant heterogeneity (sensitivity, I2 = 95.19%, p < 0.001; specificity, I2 = 95.29%, p < 0.001; DOR, I2 = 92.9%, p < 0.001). The SROC curve was with an area under curve (AUC) of 0.95 (95% CI: 0.93-0.97).

Conclusion

Circulating miR-155 has a potential in the diagnosis of BC.
Diagnosis, management and long term cardiovascular outcomes of phenotypic profiles in pulmonary hypertension associated with congenital diaphragmatic hernia
Authors: Chaudhari Tejasvi , Schmidt Sotomayor Nadia , Maheshwari Rajesh
Published: March 2024

Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm resulting in herniation of viscera into the chest. This condition is characterized by pulmonary hypoplasia, pulmonary hypertension (PH) and cardiac ventricular dysfunction. PH is a key component of the pathophysiology of CDH in neonates and contributes to morbidity and mortality. Traditionally, PH associated with CDH (CDH-PH) is thought to be secondary to increased pulmonary arterial resistance and vasoreactivity resulting from pulmonary hypoplasia. Additionally, there is increasing recognition of associated left ventricular hypoplasia, dysfunction and elevated end diastolic pressure resulting in pulmonary venous hypertension in infants with CDH. Thus, hemodynamic management of these infants is complex and cautious use of pulmonary vasodilators such as inhaled nitric oxide (iNO) is warranted. We aim to provide an overview of different phenotypic profiles of CDH associated PH and potential management options based on current evidence and pathophysiology.
Awareness, access, and communication: provider perspectives on early intervention services for children with sickle cell disease
Authors: Heitzer Andrew M. , MacArthur Erin , Tamboli Mollie , Wilson Ashley , Hankins Jane S. , Hoyt Catherine R.
Published: March 2024

Purpose

This study aimed to identify determinants influencing the utilization of early intervention services among young children with sickle cell disease (SCD) based on perspectives from medical and early intervention providers.

Design and methods

Early intervention and medical providers from the catchment area surrounding St. Jude Children's Research Hospital and Washington University were recruited (20 total providers). Interviews were completed over the phone and audio recorded. All interviews were transcribed verbatim, coded, and analyzed using inductive thematic analysis.

Results

Three overarching themes were identified from both groups: Awareness (e.g., lack of awareness about the EI system and SCD), Access (e.g., difficulties accessing services), and Communication (e.g., limited communication between medical and early intervention providers, and between providers and families). Although these three themes were shared by medical and early intervention providers, the differing perspectives of each produced subthemes unique to the two professional fields.

Conclusions

Early intervention services can limit the neurodevelopmental deficits experienced by young children with SCD; however, most children with SCD do not receive these services. The perspectives of early intervention and medical providers highlight several potential solutions to increase early intervention utilization among young children with SCD.
Comprehensive effect of Naoxintong capsule combined with Western medicine on coronary heart disease after percutaneous coronary intervention: a meta-analysis
Authors: Yu Liyuan , Huang Peiying , Wang Meida , Li Zhishang , Cai Hairong , Feng Yuchao , Wu Lulu , Peng Weihang , Zeng Jing , Chen Bojun
Published: March 2024

Aims:

To systematically evaluate the comprehensive effect of combining Naoxintong capsule (NXT) with Western medicine (WM) on coronary heart disease post-percutaneous coronary intervention (PCI).

Methods:

Randomized controlled trials (RCTs) of NXT for patients with CHD after PCI were systematically searched across multiple databases, including the Cochrane Library, PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP), and Wan Fang, from inception until 31 January 2023. Study selection, data extraction, and quality assessment were performed by two independent reviewers. The quality of the included studies was evaluated using version 2 of the Cochrane risk-of-bias tool (RoB 2), and data analysis was performed using R4.2.2.

Results:

Fifteen RCTs conducted between 2011 and 2022 and involving 1,551 patients were identified, with 774 and 777 patients in the experimental and control groups respectively. It was found that the NXT and WM combination was superior to the WM therapy alone in terms of the effective clinical rate (odds ratio [OR] = 4.69, 95% confidence interval [CI] = 2.13–10.30), effective rate in electrocardiogram (OR = 6.92, 95% CI = 3.44–13.92), effective rate in angina (OR = 5.90, 95% CI = 3.04–11.46), left ventricular ejection fraction (mean difference [MD] = 4.94, 95% CI = 2.89–6.99), brain natriuretic peptide (MD = −294.00, 95% CI = −584.60 to −3.39), creatine kinase-MB (MD = −7.82, 95% CI = −13.26 to −2.37), major adverse cardiovascular events (OR = 0.24, 95% CI = 0.14–0.43), maximum platelet aggregation rate (MD = −8.33, 95% CI = −11.64 to −5.01), and Chinese medicine evidence score (OR = 9.79, 95% CI = 3.57–26.85). However, there was no significant difference in cardiac troponin I level reduction (MD = −0.13, 95% CI = 0.35–0.09) or the occurrence of adverse medicine events (OR = 0.92, 95% CI = 0.41–2.05). Meta-regression and subgroup analyses indicated that NXT capsule dosage, treatment duration, and patient baseline characteristics contributed to the heterogeneity.

Conclusion:

A combination of NXT and WM can improve clinical outcomes in patients undergoing PCI. However, further studies are needed to confirm the reliability and safety of this combined treatment approach.

Systematic Review Registration:

PROSPERO, https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=369174, Identifier CRD42022369174.
Response of species dominance and niche of plant community to wetland degradation along alpine lake riparian
Authors: Wu Shengnan , Dong Shikui , Wang Ziying , Li Shengmei , Ma Chunhui , Li Zhouyuan
Published: March 2024

Alpine wetland degradation threatens riparian biodiversity and ecological balance. Our study, conducted in July 2020 along the northern and eastern shores of Qinghai Lake, seeks to unravel the impacts of such degradation on plant species dominance and ecological niches, using advanced network analysis methods to explore the dynamics and survival strategies of plant species. We applied a space-to-time method to delineate three wetland degradation stage: a healthy swamp wetland, a slightly degraded wet meadow, and a degraded dry meadow. Six representative sampling points were chosen. At each point, three sample lines were randomly established, radiating outward from the center of the lake wetland, with each stage of degradation meticulously examined through three replicates to assess the plant communities in terms of species composition, plant height, coverage, and abundance. The results indicated: Species such as Kobresia tibetica and Leymus secalinus exhibit remarkable abundance across various stages of wetland degradation, indicating a robust tolerance to these conditions. This observation, coupled with the complexity of plant community structures in degrading wetlands, suggests that such intricacy cannot be solely attributed to the dominance of particular species. Instead, it is the result of a diverse array of species adapting to fluctuating water levels, which promotes increased species richness. Despite the prominence of species that exhibit rapid growth and reproduction, the ecological significance of less abundant species in contributing to the community’s complexity is also notable. Changes in habitat conditions due to wetland degradation facilitate both competitive and cooperative interactions among species, highlighting the dynamic nature of these ecosystems. Our analysis shows no significant linear relationship between the ecological niche overlap values and niche widths of plant species. However, the strategies employed by dominant species for competition and resource acquisition, as observed in the ecological niche overlap networks, underscore the adaptive capacity of plant communities. These insights underscore the need for tailored restoration strategies to conserve the biodiversity of alpine lake riparian ecosystems. This research not only sheds light on the resilience and adaptability of ecosystems in the Qinghai-Tibetan Plateau but also offers valuable lessons for the conservation of similar habitats worldwide. Our findings underscore the need for tailored restoration strategies to conserve the biodiversity of alpine lake riparian ecosystems. This research not only sheds light on the resilience and adaptability of ecosystems in the Qinghai-Tibetan Plateau but also offers valuable lessons for the conservation of similar habitats worldwide.
BnAP2-12 overexpression delays ramie flowering: evidence from AP2/ERF gene expression
Authors: Zhang Xiaoyang , Peng Wenxian , Chen Hao , Xing Hucheng
Published: March 2024

Introduction

The APETALA2/ethylene response factor (AP2/ERF) superfamily plays a significant role in regulating plant gene expression in response to growth and development. To date, there have been no studies into whether the ramie AP2/ERF genes are involved in the regulation of flower development.

Methods

Here, 84 BnAP2/ERF members were identified from the ramie genome database, and various bioinformatics data on the AP2/ERF gene family, structure, replication, promoters and regulatory networks were analysed. BnAP2-12 was transferred into Arabidopsis through the flower-dipping method.

Results

Phylogenetic analysis classified the 84 BnAP2/ERF members into four subfamilies: AP2 (18), RAV (3), ERF (42), and DREB (21). The functional domain analysis of genes revealed 10 conserved motifs. Genetic mapping localised the 84 members on 14 chromosomes, among which chromosomes 1, 3, 5, and 8 had more members. Collinearity analysis revealed that 43.37% possibly resulted from replication events during the evolution of the ramie genome. Promoter sequence analysis identified classified cis-acting elements associated with plant growth and development, and responses to stress, hormones, and light. Transcriptomic comparison identified 3,635 differentially expressed genes (DEGs) between male and female flowers (1,803 and 1,832 upregulated and downregulated genes, respectively). Kyoto Encyclopaedia of Genes and Genomes pathway analysis categorised DEGs involved in metabolic pathways and biosynthesis of secondary metabolites. Gene Ontology enrichment analysis further identified enriched genes associated with pollen and female gamete formations. Of the 84 BnAP2/ERFs genes, 22 and 8 upregulated and downregulated genes, respectively, were present in female flowers. Co-expression network analysis identified AP2/ERF members associated with flower development, including BnAP2-12. Subcellular localisation analysis showed that the BnAP2-12 protein is localised in the nucleus and cell membrane. Overexpression BnAP2-12 delayed the flowering time of Arabidopsis thaliana.

Conclusion

These findings provide insights into the mechanism of ramie flower development.
Evaluating the psychometric properties of the Swedish version of the Impostor Profile scale (IPP30)
Authors: Doshi Vini , Antens Marijn , Daukantaitė Daiva
Published: March 2024

The Impostor Profile scale (IPP30) is a recently developed tool designed to delve into the nuanced aspects of the Impostor Phenomenon (IP), a psychological phenomenon where individuals wrongly attribute their successes to external factors, discounting their own abilities and often feeling like frauds. This study aimed to assess the psychometric properties, including factor structure, internal consistency, and nomological validity, of the Swedish version of IPP30 (S-IPP30). In a sample of Swedish students (N = 1,010; 76.7% women; Mage = 25.65, SDage = 6.43), Exploratory and Confirmatory Factor Analyses were conducted to scrutinize S-IPP30’s structure. The analyses supported a bifactor model with six specific factors and one overarching factor. However, two items in the scale displayed poor alignment with their intended subscales, adversely affecting the internal consistency of the two subscales. Consequently, a rephrasing of these items was suggested. The remaining four S-IPP30 subscales exhibited good internal consistency (Cronbach’s α = 0.76–0.90, McDonald’s ω = 0.77–0.91). Convergent validity was confirmed by largely replicating correlations among various S-IPP30 facets, the unidimensional IP measure, personality variables, and self-esteem, thereby accomplishing the goal of validating S-IPP30. This proposed modification of the two items requires further validation using a new sample to ensure its appropriateness and effectiveness in measuring the intended constructs.
The interaction between acute emotional states and executive functions in youth elite soccer players
Authors: Knöbel Simon , Weinberg Henrietta , Heilmann Florian , Lautenbach Franziska
Published: March 2024

Introduction

Executive functions (EFs) are relevant for game performance in soccer and have been investigated in previous research. However, emotions are a well-known performance factor in sport competitions, which may affect performance by means of EFs. The diagnostic of EFs has mainly been performed disregarding the potential impact of emotional states. Thus, we aimed to initially analyze interaction between emotional states and EFs in two studies with male youth elite soccer players.

Methods

In the first study, 105 players (Mage = 14.97) completed computerized tasks assessing inhibition, cognitive flexibility and working memory. In the second study, 92 players (Mage = 15.17) performed adapted and validated tests of inhibition (n = 45) or cognitive flexibility (n = 47) in a soccer-specific setting (SoccerBot360). Emotional and affective states were assessed using the German Sport Emotion Questionnaire and self-assessment manikins.

Results

For the computerized tasks, results showed a significant negative correlation between switch costs accuracy and tension, r = 0.28, indicating lower error rates with higher levels of tension. In contrast, in the SoccerBot360 we found significant positive correlations for response time and tension (no-switch: r = 0.38; switch: r = 0.39) representing prolonged response times related to tension. Further, for soccer-specific inhibition, positive emotions were significantly positively correlated with response time (congruent: r = 0.32; incongruent: r = 0.32). Subsequent regression analyses also demonstrate that valence and arousal effectively explain variance in cognitive performance parameters under neutral conditions.

Discussion

Accordingly, the ambiguity of the results suggests high variability in EF performance, affective and emotional states as well as a potentially moderating influence of other variables such as context and task difficulty. Thus, future cognitive diagnostic research should integrate assessments of emotional and affective states as these may contribute to situational fluctuations in EF performance.
Adopting the RE-AIM analytic framework for rural program evaluation: experiences from the Advance Care Planning via Group Visits (ACP-GV) national evaluation
Authors: Matthieu Monica M. , Taylor Laura D. , Adkins David A. , Williams J. Silas , Hu Bo , Oliver Ciara M. , McCullough Jane Ann , Mallory Mary J. , Smith Ian D. , Painter Jacob T. , Ounpraseuth Songthip T. , Garner Kimberly K.
Published: March 2024

Introduction

To support rigorous evaluation across a national portfolio of grants, the United States Department of Veterans Affairs (VA) Office of Rural Health (ORH) adopted an analytic framework to guide their grantees' evaluation of initiatives that reach rural veterans and to standardize the reporting of outcomes and impacts. Advance Care Planning via Group Visits (ACP-GV), one of ORH's Enterprise-Wide Initiatives, also followed the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. ACP-GV is a national patient-centered intervention delivered in a large, veterans integrated healthcare system. This manuscript describes how RE-AIM was used to evaluate this national program and lessons learned from ORH's annual reporting feedback to ACP-GV on their use of the framework to describe evaluation impacts.

Methods

We used patient, provider, and site-level administrative health care data from the VA Corporate Data Warehouse and national program management databases for federal fiscal years (FY) spanning October 1, 2018–September 30, 2023. Measures included cumulative and past FY metrics developed to assess program impacts.

Results

RE-AIM constructs included the following cumulative and annual program evaluation results. ACP-GV reached 54,167 unique veterans, including 19,032 unique rural veterans between FY 2018 to FY 2023. During FY 2023, implementation adherence to the ACP-GV model was noted in 91.7% of program completers, with 55% of these completers reporting a knowledge increase and 14% reporting a substantial knowledge increase (effectiveness). As of FY 2023, 66 ACP-GV sites were active, and 1,556 VA staff were trained in the intervention (adoption). Of the 66 active sites in FY 2023, 27 were sites previously funded by ORH and continued to offer ACP-GV after the conclusion of three years of seed funding (maintenance).

Discussion

Lessons learned developing RE-AIM metrics collaboratively with program developers, implementers, and evaluators allowed for a balance of clinical and scientific input in decision-making, while the ORH annual reporting feedback provided specificity and emphasis for including both cumulative, annual, and rural specific metrics. ACP-GV's use of RE-AIM metrics is a key step towards improving rural veteran health outcomes and describing real world program impacts.
“Ripping off the band-aid”: uncovering future health care professionals' “fractured knowledge” about sexual and reproductive health
Authors: Mejia Angie , Nyhus Kara , Burley Tessie , Myhre Alexis , Montes Marcela , Osiecki Kristin , Randolph Anita C.
Published: March 2024

Background

Research has shown the role of identity on future health professionals' confidence and competence in addressing the sexual and reproductive health (SRH) needs of their patients. While there has been some work in increasing the sexual health literacy of future providers via various curricular approaches and comprehensive clinical-based training, there are research gaps on how social differences around identity impact future healthcare professionals’ knowledge and practices around SRH.

Objectives

This article presents research findings on the experiences of US undergraduate students attending a campus that provides training in the health sciences and health professions. Our study aims to understand the perspectives of these students as they pertain to their future career choices in healthcare, with a focus on how their past experiences learning about sex, sexuality, and reproduction impact their current and future professional trajectories.

Methods

We present a qualitative analysis from 40 in-depth interviews with U.S. undergraduates. The interview questions were designed in collaboration with undergraduate researchers interested in sexual health education. These student researchers collected all the interview data and worked with senior researchers to analyze some of these data.

Results

The themes that emerged from the interviews were around experiences with what students perceived as “fractured” sexual and reproductive health (SRH) knowledge they received as children and adolescents. This knowledge shaped essential aspects of their identity as young adults and future healers. Data indicated unique processes implicated in how past as well as present socialization experiences learning about sex, sexuality, and reproduction positions undergraduates in health professions to see young adulthood as a journey of “catching up” on sexual knowledge but also as an ongoing experience of anticipation and planning influencing their career-building journey.

Conclusions

The importance of sexual health literacy among healthcare professionals cannot be overstated, as it is vital in providing patient-centered and non-judgmental sexual and reproductive health (SRH) care and services. To date, there is a shortage of studies looking at the impact of sexual health knowledge on healthcare professionals. More research is needed on educational strategies that could be implemented at the intra-personal level to assist college-aged young adults in healthcare career tracks to “catch up” or “fill in the gaps” in their sexual education journey.
Using the automated HYPERNETS hyperspectral system for multi-mission satellite ocean colour validation in the Río de la Plata, accounting for different spatial resolutions
Authors: Dogliotti Ana I. , Piegari Estefanía , Rubinstein Lucas , Perna Pablo , Ruddick Kevin G.
Published: March 2024

Validation of water reflectance usingin situdata is essential to ensure the quality of ocean colour satellite-derived products useful for water quality monitoring, like turbidity and chlorophyll-a concentration. Since December 2021, the HYPERNETS automated hyperspectral system has been collecting data in the optically complex and highly turbid waters of the Río de la Plata, an ideal scenario for testing atmospheric correction algorithms’ performance. The site, located 60 km south of Buenos Aires (Argentina), is described in relation to the water reflectance spectral features and variability using high spatial resolution imagery and a methodology is proposed to objectively select a sensor-specific location of a reference pixel for satellite validation. Six months of data is used to evaluate surface water reflectance operational products from multi-spectral systems like Landsat 8&9/OLI (L89/OLI), Sentinel-2/MSI (S2/MSI) & Sentinel-3/OLCI (S3/OLCI), and PlanetScope SuperDoves (PS/SD), and also non standard products for Aqua/MODIS (Aqua/MODIS) and SNPP&JPSS1/VIIRS (SJ/VIIRS) missions. Moreover, the standard surface water reflectance product from the hyperspectral PRISMA mission could also be evaluated. The matchups show general good results whenin situmeasurements are compared to L2 standard products of high spatial resolution sensors that use land-based atmospheric correction approach, if sun glint contamination is avoided. Low mean relative percentage difference was found for S2/MSI (2.45%) and L89/OLI (−3.52%), but higher for PS/SD (30.7%). In turn, S3/OLCI medium resolution also showed low mean relative differences (2.31%), while SJ/VIIRS and Aqua/MODIS showed larger and negative differences (−16.35 for SJ/VIIRS and −35.6% for Aqua/MODIS) which showed a clear increase towards the shortest blue bands. The results show the great potential of the HYPERNETS automated system to provide high quality and quantity of data for validation of satellite data at all visible and near infrared (VNIR, 400–900 nm) wavelengths in a multi-mission perspective.
c-HAND: near real-time coastal flood mapping
Authors: Wang Mark , Passalacqua Paola , Cai Shukai , Dawson Clint
Published: March 2024

The Texas Gulf Coast region contains significant centers of population, infrastructure, and economy and is threatened by intensifying tropical storms. The flooding from these tropical storms often has multiple compounding drivers. This characteristic presents a complex numerical problem where a simulation must consider multiple hydrologic forcings. While several procedures exist for addressing this problem numerically, they tend to be resource-intensive and cannot be conducted in near real-time. We extend GeoFlood, a reduced physics approach for fluvial flood forecasting, to rapidly predict coastal and compound fluvial-coastal inundation. This method is validated against a numerical ocean circulation model (ADCIRC) simulation of Hurricane Ike, a major coastal flooding event that happened on the Texas Gulf Coast in 2008. We show that the inundation map generated by coastal HAND (c-HAND) has reasonable agreement with the ADCIRC simulation while taking about 1.7% of the time currently needed to run ADCIRC on a supercomputer. While our model correctly predicts 99% of ADCIRC-inundated DEM cells, it also overpredicts inundated area by a factor of approximately 27%. We combine c-HAND with the GeoFlood framework for fluvial flood forecasting to create a compound fluvial-coastal inundation mapping workflow that can be run in near real-time. c-HAND's fast wall-clock time and low CPU requirements can support decision making by first response personnel. The method provides timely and convenient access to crucial information, such as the locations of flooded roads and inundated coastal areas.
Starters vs. non-starters differences in vertical jump force-time metrics in female professional volleyball players
Authors: Cabarkapa Damjana V. , Cabarkapa Dimitrije , Fry Andrew C.
Published: March 2024

As one of the fundamental volleyball skills, countermovement vertical jump (CMJ) has been commonly implemented in the applied sports setting as a non-invasive and time-efficient assessment of athletes' lower-body neuromuscular function. The purpose of the present study was to examine the differences in CMJ characteristics between starters and non-starters within a cohort of professional female volleyball players. Nineteen athletes competing in one of the top European leagues (i.e., SuperLeague) volunteered to participate in the present investigation. Following the completion of a warm-up protocol, each athlete performed three maximal-effort CMJs with no arm swing while standing on a uni-axial force plate system sampling at 1,000 Hz. The following force-time metrics were used for performance analysis purposes: braking phase duration and impulse, eccentric and concentric duration, mean and peak force and power, contraction time, jump height, and reactive strength index-modified. Mann–WhitneyUand independentt-tests revealed no statistically significant differences (p > 0.05) during both eccentric and concentric phases of CMJ between the players included in the starting lineup (n = 9) and their substitutions (n = 10), with the effect sizes being small to moderate in magnitude (g = 0.053–0.683). While further research is warranted on this topic, these results suggest that securing a position in a starting lineup at the professional level of volleyball play may be more contingent on the player's ability to proficiently execute sport-specific skills (e.g., blocking, attacking), rather than the performance on the CMJ assessment, considering that the observed values for both groups fall within the desired ranges for this specific population of athletes.
An Innovative Mathematical Model of the Spine: Predicting Cobb and Intervertebral Angles Using the 3D Position of the Spinous Processes Measured by Vertebral Metrics
Authors: Gabriel Ana Teresa , Quaresma Cláudia , Vieira Pedro
Published: March 2024

Back pain is regularly associated with biomechanical changes in the spine. The traditional methods to assess spine biomechanics use ionising radiation. Vertebral Metrics (VM) is a non-invasive instrument developed by the authors in previous research that assesses the spinous processes’ position. However, the spine model used by VM is not accurate. To overcome it, the present paper proposes a pioneering and simple articulated model of the spine built through the data collected by VM. The model is based on the spring–mass system and uses the Levenberg–Marquardt algorithm to find the arrangement of vertebral bodies. It represents the spine as rigid geometric transformations from one vertebra to the other when the extremity vertebrae are stationary. The validation process used the Bland–Altman method to compare the Cobb and the intervertebral angles computed by the model with the radiographic exams of eight patients diagnosed with Ankylosing Spondylitis. The results suggest that the model is valid; however, previous clinical information would improve outcomes by customising the lower and upper vertebrae positions, since the study revealed that the C6 rotation slightly influences the computed angles. Applying VM with the new model could make a difference in preventing, monitoring, and early diagnosing spinal disorders.
Comparative Analysis of Force and Eddy Current Position Sensing Approaches for a Magnetic Levitation Platform with an Exceptional Hovering Distance
Authors: Bonetti Reto , Mirić Spasoje , Kolar Johann W.
Published: March 2024

This paper provides a comparative analysis between a force sensor and an eddy current sensor, focusing on their usability to determine the position of a circular levitating permanent magnet (PM) mover within an axially symmetric magnetic levitation platform (MLP) with an exceptionally large air gap. The sensors enable closed-loop control, which is essential for accurately and stably maintaining the mover’s radial position. For the considered MLP, a change in radial position in principle results in a tilting of the mover, i.e., a deviation from the parallel alignment relative to the stator. As both the radial position and the tilting angle affect the sensors’ (force and eddy current) output voltage, an observer must deduce the radial position from the output sensor’s voltage, requiring a comprehensive MLP dynamic model and calibration of the models for both sensing approaches. The paper discusses the advantages and weaknesses of each sensor concept, exploring operational principles and performance in levitation tests. The force sensor exhibits versatility, proving functional across various application scenarios, such as when the mover is sealed in a conductive, non-magnetic chamber. In contrast, due to its high-frequency operation, the eddy current sensor is more straightforward to characterize, simplifying its behavior relative to the mover’s slower dynamics. Measurements are conducted to validate the models, showing the eddy current sensor’s robustness against disturbances and imperfections in the MLPs and its immunity to cross-axis interference. Conclusively, in levitation experiments where the mover is vertically distanced at 104 mm from the stator, the eddy current sensor achieves a position tracking precision about ten times better and a signal-to-noise ratio (SNR) ten times higher compared to the off-the-shelf force sensor, confirming its better performance and reliability; however, it cannot be used in applications where conductive objects are present in the air gap. Furthermore, additional experiments are conducted on the MLP using the eddy current sensor to show the controller’s robustness and dynamic reference tracking capability, with and without a payload.
A Mini Review (PRISMA) on Causes of Incidents and Injuries Occurring in Agricultural Workplaces
Authors: Choi Won , Kim Kyungsu , Jung Wongeon
Published: March 2024

Agriculture, alongside construction and mining, is one of the three most hazardous industries, and is characterized by numerous risk factors for occupational accidents. Unlike other industries, agriculture faces significant safety concerns related to the natural environment. Determining the causes of accidents is therefore imperative for accident prevention. However, the difficulty in investigating accidents owing to inadequate reporting and management systems among self-employed farmers hampers the determination of their causes. This study aims to determine the factors influencing agricultural accidents through a literature review. A systematic literature search was conducted according to the PRISMA guidelines. The initial search yielded 165 articles of which 34 papers were selected after removing those by applying the selection criteria. The selected papers were categorized into three domains: work accidents, machinery accidents, and farmer safety promotion. Accident causes were classified using the 4M technique: machine, media, man, and management. The results were visualized with a heat map. The main causes of accidents thus identified were insufficient operation/management, inappropriate work situation, and insufficient education/training. The findings of this study can serve as foundational data for developing measures to improve working environments not only in agriculture but also in other high-hazard industries.
Bridging the Gap: Scaling Up the Sustainable Production of the Yellow Mealworm with Agricultural By-Products—Insights into Larval Growth and Body Composition
Authors: Vrontaki Mariastela , Adamaki-Sotiraki Christina , Rumbos Christos I. , Anastasiadis Anastasios , Athanassiou Christos G.
Published: March 2024

Amidst the escalating global demand for protein-rich livestock feed, there’s an urgent call to explore innovative alternatives. Insects, renowned for their rich protein, lipid, and nutrient profiles, offer a sustainable solution. Integrating agricultural waste into insect diets emerges as a promising strategy to alleviate rearing costs. However, large-scale investigations into by-product valorization remain limited. Thus, our study aims to evaluate Greek agricultural by-products—brewer’s spent grains, rice bran, oat and maize by-products, and animal feed mill leftovers—as potential feedstock for Tenebrio molitor larvae, an insect species that is authorized by the European Union for both livestock feed and human consumption. In this study, the larval growth and body composition were assessed in commercial trays, unveiling optimal performance with rice bran and brewer’s spent grains. Conversely, larvae fed with animal feed mill leftovers and maize by-products displayed suboptimal outcomes. These findings underscore the potential efficacy of integrating locally produced agricultural by-products into T. molitor commercial production. Such an approach not only addresses the growing demand for protein-rich livestock feed but also offers a sustainable solution to agricultural waste management. In conclusion, our research contributes valuable insights towards developing economically viable insect farming.
Study the Flow Capacity of Cylindrical Pellets in Hopper with Unloading Paddle Using DEM
Authors: Huang Huinan , Zhang Yan , Wang Defu , Fu Zijiang , Tian Hui , Shang Junjuan , Helal Mahmoud , Lv Zhijun
Published: March 2024

The hopper is an important piece of basic equipment used for storing and transporting materials in the agricultural, grain, chemical engineering, coal mine and pharmaceutical industries. The discharging performance of hoppers is mainly affected by material properties and hopper structure. In this work, the flow capacity of cylindrical pellets in the hopper with the unloading paddle is studied. A series of numerical simulation analyses with the aid of the discrete element method (DEM) platform are carried out. Then, the discharging process is illustrated, and the flow capacity of pellets in the hopper is analyzed by the mass flow index (MFI), the dynamic discharging angle (DDA) formed in the discharging process and porosity among pellets. Furthermore, the effect of parameters such as hopper half angle, rotation speed of the unloading paddle and outlet diameter of the hopper is investigated. The results show that MFI increases with an increase in hopper half angle or outlet diameter and a decrease in rotation speed. Meanwhile, DDA and porosity decrease with the increase in the hopper half angle or outlet diameter and the decrease in the rotation speed. Finally, the MFI ~0.24 is identified as the criterion to distinguish the mass flow from the funnel flow for the hopper with an unloading paddle, and the optimization results are decided as follows: hopper half angle greater than 60°, outlet diameter greater than 60 mm and rotation speed between 45 rpm and 60 rpm. These results should be useful for providing a theoretical reference for the optimization design of feeding devices for swine feeders.
Air Assistance and Electrostatic Spraying in Soybean Crops
Authors: Bueno Mariana Rodrigues , Sousa Alves Guilherme , Silva Sérgio Macedo , Hachiya Tiago Seiji S. , Guimarães Hasle Thiago S. , Costa Gustavo Araújo , Gonçalves Felipe Soares , Oliveira Mateus A. V. G.
Published: March 2024

This study aimed to evaluate the efficiency of air assistance associated with electrostatic spraying in terms of spray deposition and yield (Experiment 1), and the coverage and droplet density on soybean crops at different working speeds (Experiment 2). The treatments in Experiment 1 corresponded to combinations of electrostatic systems associated with air assistance at three airspeeds (21, 25, and 30 m·s−1) plus a conventional treatment without electrostatic or air assistance. The treatments in Experiment 2 corresponded to three working speeds (3.3, 4.2, and 5.0 m·s−1) with or without the use of an electrostatic system. All applications were performed with a self-propelled sprayer, delivering 75 L·ha−1 with ATR 2.0 nozzles. A blue tracer, detectable as absorbance with a spectrophotometer, was added to the spray solution to evaluate deposition. The results indicate that an air assistance at 21 m·s−1 plus electrostatic system increased the amount of spray deposited on the middle and top leaves of the plants in relation to the conventional system, with yield increments of up to 621 kg·ha−1. The slowest working speed (3.3 m·s−1) combined with air assistance and an electrostatic system provided the greatest spray deposition, droplet coverage, and density on the bottom leaves of soybean crops.
Supplementation of Extender with Melatonin Improves the Motility, Mitochondrial Membrane Potential, and Fertilization Ability of Cryopreserved Brown-Marbled Grouper Sperm
Authors: Ruan Qingxin , Yang Sen , Hua Sijie , Zhang Weiwei , Li Duo , Yang Yang , Wang Xi , Wang Qinghua , Meng Zining
Published: March 2024

Sperm cryopreservation is a valuable tool for breeding, conservation, and genetic improvement in aquatic resources, while oxidative damage will cause a decline in sperm quality during this progress. Melatonin (MT), a natural antioxidant hormone, is used as an additive in sperm cryopreservation to reduce cellular damage from oxidative stress. Here, we aimed to investigate the effect of adding MT to the freezing medium in sperm cryopreservation of brown-marbled grouper (Epinephelus fuscoguttatus). Different concentrations of MT (0, 0.1, 0.25, and 0.5 mg/mL) were tested. We evaluated sperm motility, viability, apoptosis, mitochondrial membrane potential (MMP), and fertilization ability to assess the effects of MT supplementation. Our results demonstrated that the addition of MT to the extender improved the post-thaw motility, MMP, and fertilization ability of brown-marbled grouper sperm. The total motility, curvilinear velocity, straight linear velocity, and average path velocity in MT-treated groups (0.1 and 0.25 mg/mL) exhibited significantly higher values than that of the control group. A higher MMP (p < 0.05) was observed in the group treated with 0.25 mg/mL MT, suggesting that supplementation of MT in the extender might be able to protect mitochondrial membrane integrity effectively. Regarding fertilizing ability, 0.25 mg/mL MT yielded a significantly higher hatching rate than the control. An adverse effect was found with the concentration of MT up to 0.5 mg/mL, suggesting the possible toxicity of a high-dose addition. In this study, we optimized the sperm cryopreservation protocol of brown-marbled grouper, which might be valuable for sperm cryopreservation and sample commercialization of groupers and other fish.
Prioritization of Appearance over Health and Temperament Is Detrimental to the Welfare of Purebred Dogs and Cats
Authors: Morel Elodie , Malineau Laureline , Venet Charlotte , Gaillard Virginie , Péron Franck
Published: March 2024

Fashions in the appearance of purebred dogs and cats are encouraged by celebrity culture, social media, and online impulse buying. The popularity of characteristics perceived as cute, quirky, and anthropomorphic has driven increasingly exaggerated breed features appealing to aesthetics rather than health. ‘Hypertypes’ of some breeds have emerged that take a breed’s distinctive appearance to extremes beyond the intended interpretation of breed standards. This has severe, direct and indirect health and welfare consequences. Extreme conformations are associated with chronic health conditions including brachycephalic obstructive airway disorder, ocular, dental, skin, and musculoskeletal disorders. Puppy and kitten farms and illegal traders that meet the demand for hypertypes are associated with poor husbandry that neglects the physical, behavioral, and mental health of parents and offspring. A multidimensional approach involving collaboration between breeders, geneticists, owners, veterinarians, kennel clubs, cat fanciers’ associations, animal charities, the academic and research communities, commercial enterprises, and governments is needed to safeguard breeds and tackle these challenges. There are many ongoing initiatives by national kennel clubs and global partnerships to educate pet owners and support responsible pet ownership and sustainable breeding. The resounding message is that health, temperament, and well-being must be prioritized over appearance.
Assessment of Waterbird Habitat Importance and Identification of Conservation Gaps in Anhui Province
Authors: Liu Yuan , Ji Xianglin , Zhou Lizhi
Published: March 2024

Wetlands are among the most important habitats of highly wetland-dependent waterbirds but are subject to ongoing habitat loss and degradation owing to intensified anthropogenic activities. The scarcity of human and natural resources makes effective habitat protection an important concern. Here, we aimed to investigate waterbird habitat protection methods for Anhui Province, China, a critical stopover and wintering area on the East Asian-Australasian Flyway that features rich wetland resources subject to significant habitat loss and degradation. We evaluated the status and importance of 306 wintering waterbird habitats and identified the key environmental influences and current protection gaps using the entropy weights method and generalized additive modeling. We found 73 important habitats for waterbirds in Anhui Province, which were classified into levels of importance (descending from I to V) according to the natural discontinuity method. Level I and Level II habitats were mainly located in the Yangtze River floodplain and Level IV habitats in the Huaihe River floodplain. The gap analysis showed that 42 important waterbird habitats had protection gaps, accounting for 57.53% of the total area. Waterbird habitat importance was significantly correlated with elevation, normalized vegetation index, lake area, and lake circumference but not with distance from roads or population density. The results of this study provide scientific information for waterbird habitat conservation planning, which is crucial for maintaining wetland ecosystem functions.
Effects of L-Type Voltage-Gated Calcium Channel (LTCC) Inhibition on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure
Authors: Lee Chang-Jun , Lee Song-Hee , Kang Beom-Seok , Park Min-Kyu , Yang Hyun-Wook , Woo Seo-Young , Park Se-Wan , Kim Dong-Yeon , Jeong Hyun-Ho , Yang Won-Il , Kho A-Ra , Choi Bo-Young , Song Hong-Ki , Choi Hui-Chul , Kim Yeo-Jin , Suh Sang-Won
Published: March 2024

Epilepsy, marked by abnormal and excessive brain neuronal activity, is linked to the activation of L-type voltage-gated calcium channels (LTCCs) in neuronal membranes. LTCCs facilitate the entry of calcium (Ca2+) and other metal ions, such as zinc (Zn2+) and magnesium (Mg2+), into the cytosol. This Ca2+ influx at the presynaptic terminal triggers the release of Zn2+ and glutamate to the postsynaptic terminal. Zn2+ is then transported to the postsynaptic neuron via LTCCs. The resulting Zn2+ accumulation in neurons significantly increases the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits, contributing to reactive oxygen species (ROS) generation and neuronal death. Amlodipine (AML), typically used for hypertension and coronary artery disease, works by inhibiting LTCCs. We explored whether AML could mitigate Zn2+ translocation and accumulation in neurons, potentially offering protection against seizure-induced hippocampal neuronal death. We tested this by establishing a rat epilepsy model with pilocarpine and administering AML (10 mg/kg, orally, daily for 7 days) post-epilepsy onset. We assessed cognitive function through behavioral tests and conducted histological analyses for Zn2+ accumulation, oxidative stress, and neuronal death. Our findings show that AML’s LTCC inhibition decreased excessive Zn2+ accumulation, reactive oxygen species (ROS) production, and hippocampal neuronal death following seizures. These results suggest amlodipine’s potential as a therapeutic agent in seizure management and mitigating seizures’ detrimental effects.
The Intelligent Layout of the Ship Piping System Based on the Optimization Algorithm
Authors: Wei Zhiguo , Wu Jun , Li Zhe , Cheng Shangfang , Yan Xiaojiang , Wang Shunsen
Published: March 2024

The ship piping layout is one of the essential tasks in the detailed design stage of a ship. Traditional manual expert design has disadvantages such as low efficiency, reliance on experience, and subjective influence. Therefore, this paper systematically proposes an intelligent arrangement method for ships’ single, parallel, and branch pipelines. Firstly, the traditional genetic algorithm is improved and combined with the A* algorithm to solve the intelligent arrangement problem of a single pipeline in ships. Then, the parallel pipeline and branch pipeline are split into multiple single pipelines by combining with the connection point strategy to solve the arrangement problem of parallel pipeline and branch pipeline. Finally, the optimized A*-genetic algorithm proposed in this paper is compared with the A* algorithm, particle swarm algorithm, and the labyrinth-genetic algorithm used in previous research through simulation experiments. The results show that the A*-genetic algorithm of this paper is optimal in six indexes, including length, number of elbows, energy value, fitness value, number of optimal solutions, and average number of convergence generations, in the arrangement of the single pipeline. In solving the parallel pipeline and branch pipeline arrangement problems, the all-around performance of this paper’s algorithm is better than that of A*-genetic algorithm and maze–genetic algorithm, respectively. The A*-genetic algorithm of this paper considers the quality of pipeline arrangement and the solution’s efficiency. It verifies the adaptability and superiority of the algorithm for the intelligent arrangement of various types of pipelines in ship pipelines.