bluuebunny/crossref_metadata_2025 huggingface dataset:
Simultaneous Pancreas Kidney Transplantation Improves Cardiovascular Autonomic Neuropathy with Improved Valsalva Ratio as the Most Precocious Test
Authors: Argente-Pla María , Pérez-Lázaro Antonia , Martinez-Millana Antonio , Del Olmo-García María Isabel , Espí-Reig Jordi , Beneyto-Castello Isabel , López-Andújar Rafael , Merino-Torres Juan Francisco
Published: April 2020

Background. Simultaneous pancreas-kidney (SPK) transplantation is a proven option of treatment for patients with type 1 diabetes mellitus (T1DM) and related end-stage renal disease. There is discrepancy between the results of different studies about the impact of prolonged normalization of glucose metabolism achieved by SPK on the course of diabetic complications including severe forms of diabetic neuropathy. The objective of the study was to evaluate the prevalence of cardiovascular autonomic neuropathy (CAN) in patients undergoing SPK transplantation and its evolution 10 years after transplantation. Methods. Prospective study of 81 patients transplanted in a single center from year 2002 to 2015. Autonomic function was assessed using cardiovascular autonomic reflex tests (CARTs). CARTs were made before SPK transplantation and during the follow-up. Evolution of tests after SPK transplantation was evaluated by contrasting hypotheses (paired tests). Multiple testing was adjusted with the Benjamini-Hochberg procedure with a false discovery rate of 10%. Results. 48 males and 33 females, mean age 37.4±5.7 years, mean BMI 24.0±3.4 kg/m2, and mean duration of diabetes 25.5±6.5 years, received SPK transplantation. Ten years after SPK transplantation, 56 patients re tained the pancreatic graft (42 of them with normofunctioning pancreas and 14 with low doses of insulin therapy). These 42 patients were selected for the autonomic study. Before transplant procedure, all CART results were abnormal. After SPK transplantation, paired test analysis showed an improvement of systolic blood pressure (SBP) response to orthostasis at the 5th year after SPK (p=0.03), as well as improvement of the Valsalva ratio at the 3rd (p<0.001) and 5th (p=0.001) year after SPK. After correcting for the false discovery rate, all the variables of autonomic study reached significance at different time points. Conclusions. Prevalence of CAN in patients who are candidates for SPK transplantation is high and is generally advanced. SPK transplantation improves CAN with improved Valsalva ratio as the most precocious test.
Surely You Must Be Joking, Mr. Twain!: Reengaging Science Students through Visual Aesthetics
Authors: Goodman Katherine , Hertzberg Jean , Finkelstein Noah
Published: April 2020

Researchers have established improved methods for undergraduate science and engineering education, yet these efforts often overlook the personal meaning students find in their work. Institutions of higher learning should support the creation of personal meaning along with content mastery, aspects that are both included in arts education. The authors argue that STEM educators must work to overcome student perception that content mastery and personal meaning sit at odds. The authors provide an example of a technical course that achieves these goals as well as evidence that it is possible to foster connection while developing content mastery.
Misoprostol for the prevention of post-partum haemorrhage in Mozambique: an analysis of the interface between human rights, maternal health and development
Authors: Hobday Karen , Zwi Anthony B. , Homer Caroline , Kirkham Renae , Hulme Jennifer , Wate Páscoa Zualo , Prata Ndola
Published: April 2020

Background

Mozambique has high maternal mortality which is compounded by limited human resources for health, weak access to health services, and poor development indicators. In 2011, the Mozambique Ministry of Health (MoH) approved the distribution of misoprostol for the prevention of post-partum haemorrhage (PPH) at home births where oxytocin is not available. Misoprostol can be administered by a traditional birth attendant or self-administered. The objective of this paper is to examine, through applying a human rights lens, the broader contextual, policy and institutional issues that have influenced and impacted the early implementation of misoprostol for the prevention of PPH. We explore the utility of rights-based framework to inform this particular program, with implications for sexual and reproductive health programs more broadly.

Methods

A human rights, health and development framework was used to analyse the early expansion phase of the scale-up of Mozambique’s misoprostol program in two provinces. A policy document review was undertaken to contextualize the human rights, health and development setting in Mozambique. Qualitative primary data from a program evaluation of misoprostol for the prevention of PPH was then analysed using a human rights lens; these results are presented alongside three examples where rights are constrained.

Results

Structural and institutional challenges exacerbated gaps in the misoprostol program, and sexual and reproductive health more generally. While enshrined in the constitution and within health policy documents, human rights were not fully met and many individuals in the study were unaware of their rights. Lack of information about the purpose of misoprostol and how to access the medication contributed to power imbalances between the state, health care workers and beneficiaries. The accessibility of misoprostol was further limited due to dynamics of power and control.

Conclusions

Applying a rights-based approach to the Mozambican misoprostol program is helpful in contextualising and informing the practical changes needed to improve access to misoprostol as an essential medicine, and in turn, preventing PPH. This study adds to the evidence of the interconnection between human rights, health and development and the importance of integrating the concepts to ensure women’s rights are prioritized within health service delivery.
Radiation dosimetry of 18F-AzaFol: A first in-human use of a folate receptor PET tracer
Authors: Gnesin Silvano , Müller Joachim , Burger Irene A. , Meisel Alexander , Siano Marco , Früh Martin , Choschzick Matthias , Müller Cristina , Schibli Roger , Ametamey Simon M. , Kaufmann Philipp A. , Treyer Valerie , Prior John O. , Schaefer Niklaus
Published: April 2020

Background

The folate receptor alpha (FRα) is an interesting target for imaging and therapy of different cancers. We present the first in-human radiation dosimetry and radiation safety results acquired within a prospective, multicentric trial (NCT03242993) evaluating the 18F-AzaFol (3′-aza-2′-[18F]fluorofolic acid) as the first clinically assessed PET tracer targeting the FRα.

Material and methods

Six eligible patients presented a histologically confirmed adenocarcinoma of the lung with measurable lesions (≥ 10 mm according to RECIST 1.1). TOF-PET images were acquired at 3, 11, 18, 30, 40, 50, and 60 min after the intravenous injection of 327 MBq (range 299–399 MBq) of 18F-AzaFol to establish dosimetry. Organ absorbed doses (AD), tumor AD, and patient effective doses (E) were assessed using the OLINDA/EXM v.2.0 software and compared with pre-clinical results.

Results

No serious related adverse events were observed. The highest AD were in the liver, the kidneys, the urinary bladder, and the spleen (51.9, 45.8, 39.1, and 35.4 μGy/MBq, respectively). Estimated patient and gender-averaged E were 18.0 ± 2.6 and 19.7 ± 1.4 μSv/MBq, respectively. E in-human exceeded the value of 14.0 μSv/MBq extrapolated from pre-clinical data. Average tumor AD was 34.8 μGy/MBq (range 13.6–60.5 μGy/MBq).

Conclusions

18F-Azafol is a PET agent with favorable dosimetric properties and a reasonable radiation dose burden for patients which merits further evaluation to assess its performance.

Trial registration

ClinicalTrial.gov, NCT03242993, posted on August 8, 2017
Powerful or powerless? Beyond power and powerlessness: the Leipzig Leadership Model provides some answers
Authors: Meynhardt Timo , Kirchgeorg Manfred , Suchanek Andreas , Zülch Henning
Published: April 2020

Leadership is about more than simply wielding power. The Leipzig Leadership Model places the importance of consistently contributing to a greater good at the centre of the concept of leadership. The critical factor is what leaders use their power for and what they use as orientation in the process. In this article, we describe the model and its guiding idea. The model incorporates the conviction that, in a fundamentally uncontrollable world, it is important to remain capable of acting and develop an attitude whereby leaders define themselves through a value contribution rather than status, knowledge, or power.
Educational Needs of Mothers about using Oral Rehydration Salt (ORS) at Home During Acute Diarrhea in Children under 5 at Urmia Population Research Center
Authors: Rezapour Baratali
Published: April 2020

Preventable factors such as infectious diseases (pneumonia, diarrhea, and malaria), malnutrition and neonatal complications are still the leading cause of child mortality worldwide 1 In 2013, it is estimated that 6.3 million babies born worldwide died before the age of 5, and approximately 9.2% of these deaths were due to diarrheal diseases 2, 3 in simple, accessible ways, and effective treatment can reduce diarrhea-related mortality and make hospital admissions unnecessary, and the role of mothers is the most important 4. Since the presentation of Oral Rehydration Therapy (ORT) in 1979, mortality has reduced. Diarrhea has had a steady downward trend 5. If mothers who have children under 5 years of age, used correctly ORS, they could easily resolve the problem of dehydration in acute diarrhea 6. Mothers didn’t use correctly ORS because of their Low literacy and lack of knowledge and wrong attitude about ORT7. Some health care workers provide mothers’ required equipments, regardless of their educational needs, and mothers may not use ORS. In this study, health workers identified mothers' educational needs and subsequently they trained them about using ORS at home in acute diarrhea in children under 5 years of age
Evaluasi Stabilitas Lereng Pada Tubuh Bendungan Butak, Kabupaten Grobogan, Provinsi Jawa Tengah
Authors: Pratama Adi Setya Yudha , Najib Najib , Trisnawati Devina
Published: April 2020

Bendungan Butak yang terletak di Desa Butak, Kecamatan Kradenan, Kabupaten Grobogan, Provinsi Jawa Tengah merupakan salah satu bangunan air dengan tipe bendungan homogen. Fungsi utama dari bendungan ini ialah sebagai sarana irigasi dengan luas daerah aliran 160 km2. Mengingat urgensinya, suatu bendungan dapat dikategorikan tingkat bahayanya berdasarkan hasil evaluasi stabilitas lereng bendungan. Upaya ini dapat dilakukan dengan menganalisis faktor keamanan (Fk) bendungan. Penelitian ini bertujuan untuk mengetahui nilai faktor keamanan (Fk) pada tubuh Bendungan Butak. Metode yang digunakan adalah metode observasi dan metode analisis data secara kuantitatif meliputi pemetaan geologi, pemetaan geoteknik, hasil pengeboran inti, dan uji laboratorium mekanika tanah dari contoh tanah tidak terganggu dengan uji soil test berikut uji triaxial UU serta perhitungan koefisien beban gempa terkoreksi OBE dan MDE. Hasil penelitian dari penyelidikan pemetaan permukaan diperoleh satuan endapan aluvium dengan persebaran lempung dan lanau berada di sekitar bendungan. Hasil penyelidikan bawah permukaan dengan 4 lubang bor terdiri dari tanah lempung. Parameter desain Bendungan Butak meliputi berat isi basah (γ), kohesi (c), sudut geser dalam (f), dan garis freatik muka air bendungan, serta beban gempa terkoreksi (Ko) digunakan untuk memperoleh nilai faktor keamanan (Fk) menggunakan perangkat lunak Slide V6.009 dengan metode Bishop. Hasil analisis pada 14 kondisi dari muka air maksimum diperoleh hasil Fk hitung > 1,2 Fk minimum , muka air normal dengan hasil Fk hitung > 1,1 Fk minimum, dan muka air surut cepat didapatkan hasil Fk hitung > 1,3 Fk minimum, sehingga Bendungan Butak dikategorikan memenuhi syarat keamanan dari standar Fk minimum yang ditetapkan oleh SNI 8064;2016.
Analisis Sistem Penyaliran Tambang pada Tailing Storage Facility (TSF) PT. Aneka Tambang Tbk. Pongkor, Kabupaten Bogor, Jawa Barat
Authors: Winarno Tri , Ali Rinal Khaidar , Mursaliin Muh.
Published: April 2020

Pembangunan dam TSF (Tailing Storage Facility) dibangun untuk menampung limbah hasil pengolahan emas UBPE (Unit Bisnis Pertambangan Emas) PT. ANTAM Pongkor. Pembangunan dam TSF telah selesai dilaksanakan, tetapi masih menyisakan beberapa kendala tentang pengontrolan, yang pada akhirnya menimbulkan kendala teknis, yaitu tidak tersedianya lahan lagi untuk menampung tailing hingga pasca tambang. Permasalahan tersebut akan terselesaikan  dengan mengetahui berapa lama penampungan TSF yang dibangun bisa menampung volume yang bertambah akibat curah hujan pada periode ulang tertentu dalam jangka waktu tiga tahun ke depan, terutama pada penampungan dam utama TSF. Untuk itu perlu diadakan evaluasi kapasitas tampung pada dam utama untuk mengetahui kemampuan pelayanan aktual TSF hingga tiga tahun ke depan. Metode yang digunakan dalam penelitian ini adalah metode penanggulangan air pada tambang terbuka atau penyaliran tambang. Dari hasil penelitian diketahui bahwa berdasarkan perhitungan tingkat pelayanan dam utama cukup untuk menampung curah hujan dengan periode ulang 2 tahunan, tetapi tidak memenuhi rencana pembangunan yang mampu menampung hingga tiga tahun ke depan. Untuk memperpanjang umur atau tingkat pelayanan maka penulis menyarankan untuk menambahkan pompa dan pengerukan endapan tailing, selain sebagai penambahan umur bangunan juga sebagai penyeimbang. Pengerukan tailing alangkah lebih baik dilakukan pemerataan dalam pengerukannya ini berguna untuk menambah kapasitas tampung dam utama.
Belajar dari Simeulue: Memahami Sistem Peringatan Dini Tsunami di Indonesia
Authors: Kurniasih Anis , Marin Jenian , Setyawan Reddy
Published: April 2020

Sistem peringatan dini tsunami tidak hanya menyangkut teknologi namun juga melibatkan kesiapsiagaan masyarakat sebagai komponen sosial budaya dan ekonomi politik yang perlu diidentifikasi dan diperbaiki. Masyarakat Simeulue mengangkat kearifan lokal "smong" sebagai sistem peringatan dini tsunami tradisional yang berhasil menyelamatkan mereka dari bencana. Sistem ini dapat diadaptasi dan diterapkan ke masyarakat di daerah lain yang rentan terhadap bencana yang sama. Dengan latar belakang tersebut, artikel ini disusun dengan tujuan untuk memahami dan menggali permasalahan dalam penerapan sistem peringatan dini tsunami di Indonesia melalui studi literatur. Data dan bahan diperoleh dari jurnal, prosiding, buku, majalah, wawancara dan laporan serta wawasan yang didapat saat tinjauan lapangan pada Ekspedisi Widya Nusantara tahun 2017. Hasil studi menunjukkan kesiapsiagaan terhadap gempa dan tsunami masih rendah sehingga ketika bencana terjadi masyarakat belum dapat melakukan penyelamatan secara mandiri. Belajar dari kearifan lokal masyarakat Simeulue melalui cerita smong yang dipahami sebagai sistem peringatan dini tsunami, saat ini kita membutuhkan sebuah metode pendekatan yang dapat diterima dengan mudah untuk meningkatkan kesiapsiagaan terhadap bencana. Contohnya dengan membuat program televisi atau animasi yang dapat ditonton semua kalangan. Dengan menampilkan program ini secara berkala, muatan tentang kesiapsiagaan terhadap tsunami (dan atau bencana lainnya) akan tertanam dalam memori sehingga mampu meningkatkan kesiapsiagaan penontonnya.
The ecological role of Accipitridae vultures in terrestrial landscapes of Azerbaijan
Authors: Karimov T. , Matsyura A.
Published: April 2020

Scavengers can provide ecosystem services to people by removal of dead animals that could become sources of disease. From such point of view, it seems appropriate to evaluate these benefits in Azerbaijan in quantitative terms. To this end, in 2013, an extensive monitoring was organized in the Turyanchay Reserve, which covers six regions and neighboring territories (the total population here is 640 thousand people). A high level of animal mortality in the Turyanchay Reserve is supported by the concentration of 24 species of wild mammals and 700 thousand domestic animals in the surrounding environment. The difficult terrain area is another factor leading to the death of animals. Animals grazing on hillsides often break down and die. The bodies of domestic and wild animals killed by wolves also often remain lying on this territory. In addition, vehicles traveling along the Agdash-Gabala highway cause the death of many domestic and wild animals. During the two months of the study (from June to July), 62 dead animals were found. Ten kinds of diseases were identified in 38 undecomposed bodies of these animals. Scavengers eat animal bodies in one-three days (without bones), preventing them from becoming a source of infection. The role of necrophages in minimizing of epizootic cases and improving sanitary conditions is important for ecosystems, because the blood of most animals is a carrier of diseases and most of the parasites present in it are common to both humans and animals. Scavengers can be used by veterinary organizations as indicators to simplify the identification of animal bodies and the subsequent disposal of their remains.
The incidence of people and animals with echinococcosis in the Kostanay region of the Republic of Kazakhstan
Authors: Aubakirov M. Zh. , Mustafin M. K. , Mustafin B. M. , Ergazina A. M. , Murzakayeva G. K. , Kurmanova G. T. , Domatsky V. N. , Nalobina L. V.
Published: April 2020

The aim of the research was to study the distribution of echinococcosis in humans and animals in the Kostanay region of the Republic of Kazakhstan. Research on the diagnosis of echinococcosis in humans was carried out in the Kostanay branch of the “Scientific and Practical Center for Sanitary and Epidemiological Expertise and Monitoring” of Ministry of Health of the Republic of Kazakhstan in 2000-2015. In order to establish the degree of invasion of dogs by echinococcus, fecal samples in the Kostanay region, in the areas where cases of echinococcosis in humans were registered, were taken. The incidence among the population of various age groups in the region was analyzed according to the results of studies of blood samples by enzyme-linked immunosorbent assay (ELISA) and lung radiography. It has been established that echinococcosis is a widespread disease among people living not only in the Kostanay region, but also in the Republic of Kazakhstan on the whole. Between 2000 and 2019 the number of patients with echinococcosis in the Kostanay region amounted to 249 cases. The smallest number of cases (5) was registered in 2000, and the largest in 2014-26 cases. In the years of 2002-2015. the incidence rate of echinococcosis in humans did not decrease and ranged from 1.6% to 1.5% per 100.0 thousand people. The maximum number of positive reactions by ELISA for echinococcosis was recorded in 2003, 2005, 2006 and from 2013 to 2016, when the incidence rate of people was 0.9%; 0.8%; 0.26%; 1.8%, 3.0%; 1.5%; 0.9% respectively. The peak incidence of human echinococcosis occurred in 2014 and amounted to 3.0%. The analysis of the registration of cases of echinococcosis among people of different age groups showed that out of 8 cases in 2016, 3 cases were in the population under the age of 14 and its infection rate per 100.0 thousand amounted to 1.74%. In 2017, out of 7 registered cases of the incidence of echinococcosis in humans- 2 cases were in the population under the age of 14 and its infection rate per 100.0 thousand was 1.14%. The maximum number of cases of echinococcosis in 2011-2017 was recorded in sheep, the invasion rate of Echinococcus granulosus being 3.1%, 3.5%, 4.2%, 3.1%, 5.6%, 3.0%, 2.8% respectively, while the average invasion in sheep amounted to 1.5%. There were no cases of registration of echinococcosis in horses. Judging by the results of the comparative analysis of the epizootic and epidemiological situation of echinococcosis in the Kostanay region, it should be noted that echinococcus infection occurs in all areas of the region, with approximately the same level of development of livestock production and a large number of dogs.
La procrastinación académica: teorías, elementos y modelos
Authors: Ayala Ramírez Anthony Santiago , Rodríguez Diaz Ruth Yoselin , Villanueva Quispe Wilma , Hernández Garcia Melva , Campos Ramirez Madeleine
Published: April 2020

El objetivo de esta investigación es analizar las teorías, elementos y modelos de la procrastinación en el contexto de los estilos negativos de aprendizaje, del bajo rendimiento académico, la falta de resolución de conflictos, la indebida toma de decisiones, y la postergación de la realización de las actividades; factores que debilitan de diversas maneras al proceso educativo. En este sentido, el análisis de las teorías, los elementos y los modelos de la procrastinación permiten conocer y abordar los problemas que ella genera en los estudiantes, cuyas consecuencias son multidimensionales.
Situation-based Learning Model Implementation through Thematic Learning as an Effort to Improve the Primary School Students' CPS Ability
Authors: Ramdan Muhamad , Hanifah Nurdinah , Isrokatun Isrokatun
Published: April 2020

This research aims at measuring the improvement of the students’ CPS ability through the SBL model implementation through thematic learning. This research employed a quasi-experimental design with non-equivalent control group design involving all fourth grade students in public primary schools in Sumedang Regency. Meanwhile, the sample used in the research was one of public primary schools in North of Sumedang Regency by determining that 30 students of class IV-A included in the experimental class, and 32 students of class IV-B included in the control class. Based on the test instrument of CPS ability, the research results revealed that the SBL model implementation was able to improve significantly the CPS ability in thematic learning in the experimental class.
Development of Problem-Based Comic Book as Learning Media for Improving Primary School Students’ Critical Thinking Ability
Authors: Yonanda Devi Afriyuni , Yuliati Yuyu , Saputra Dudu Suhandi
Published: April 2020

This research is motivated by the lack of teachers' ability to use media related to the students environment as teaching materials to develop primary school students' critical thinking ability. The research aims at developing problem-based learning media (PBL) using comic book in order to improve students' critical thinking ability. The research employed a research and development design using the experimental research design with a one-group pretest-posttest design. The subjects of the research were 28 fourth-grade students in one of primary schools in Indramayu Regency. The research produced a product in the form of problem-based comic media developed based on the needs of teachers and students. The subject material in the comic book contained problems that occurred in the real environment within the students. Based on the validation tests carried out by material experts, media experts and practitioners, the results revealed that the product was included in the “Very Valid” category. While, the practicality test results revealed that the product was included in the “Very Practical”.
Use of Big Book Learning Media to Improve Students’ Beginning Reading Skills in Primary Schools
Authors: Nurani Riga Zahara , Mahendra Hatma Heris
Published: April 2020

This study is motivated by the fact that there are still many lower grade students who have not been able to read fluently. Big book learning media can be used by teachers to teach beginning reading to lower grade students. The purpose of this study is to describe the use of big book learning media to improve beginning reading skills. The study employed a qualitative descriptive method. The subjects were second-grade primary school students who were still unable to read. The research was conducted in one of the primary schools in Tasikmalaya City. The results revealed that students were more enthusiastic in learning to read using big book learning media, which could be seen from an increase in students' reading skills in each meeting. By using big book learning media, in addition to learning to read through a series of letters, students were able to learn to read through images followed by the writing. Therefore, big book learning media can be used to improve students' reading skills.
APRENDIZADO DE CONTABILIDADE E A PERCEPÇÃO DO CONCEITO DE LUCRO: UM ESTUDO EXPLORATÓRIO
Authors: SANTOS LUIS PAULO GUIMARÃES DOS , FREITAS SHEIZI CALHEIRA , DIAS FILHO JOSÉ MARIA
Published: April 2020

Objetivo: o estudo procurar verificar se a compreensão do conceito de lucro e valor manifestada pelos indivíduos está associada ao nível de aprendizado formal de contabilidade.

Metodologia: A pesquisa consiste em um estudo de comparação de grupos, mediante a qual foram analisadas três amostras de sujeitos com diferentes níveis de aprendizado em contabilidade. Através de um modelo logístico, investigou-se ainda outros fatores que podem influenciar no entendimento subjacente ao conceito de lucro.

Resultados e contribuições: os resultados sugerem que não existe relação significativa entre a compreensão do conceito de lucro e o nível de aprendizado formal de contabilidade. Entretanto, observou-se que o fato de o sujeito pertencer ao gênero feminino pode exercer influência na maneira como o lucro é compreendido. Esses achados contribuem para a compreensão de como o processo formal de ensino está relacionado ao aprendizado de conceitos contábeis fundamentais e podem ser pode úteis para orientar estratégias de ensino e até mesmo os projetos político-pedagógico dos cursos de Ciências Contábeis.
SHAPE: A MATLAB Software Package for Time-Dependent Seismic Hazard Analysis
Authors: Leptokaropoulos Konstantinos , Lasocki Stanisław
Published: April 2020

Many seismic processes, in particular, those induced by technological activities for exploitation of georesources, are time dependent. The changes in time of the seismicity cause that the related seismic hazard changes in time as well. We present here the Seismic HAzard Parameters Evaluation (SHAPE) tool, which enables an assessment of the temporal changes of the mean return period (MRP) of a seismic event of a given magnitude and the exceedance probability (EP) of a given magnitude within a predefined time period. SHAPE is an open-source software package, written in MATLAB (see Data and Resources), based on the online probabilistic seismic hazard analysis applications available on IS-EPOS platform of thematic core service anthropogenic hazards of European Plate Observing System (EPOS). SHAPE is developed in two standalone versions allowing the user to select a variety of options and parameters to determine the values of EP and MRP, assuming different magnitude distribution models. The first software version (SHAPE_ver1) provides interactive parameter selection and data filtering through a graphical user interface environment, whereas the second wrapper-script-based version (SHAPE_ver2) allows fast implementation and fine-tuning of parameters. The program is particularly useful for anthropogenic seismicity cases, to monitor the changes of seismic response to technological operations, and to control the effectiveness of the undertaken hazard mitigation measures. As an example, two applications of SHAPE in case studies from the northwestern part of The Geysers geothermal field, California, and Song Tranh 2 surface water reservoir, Vietnam, are demonstrated.
Survey of WU and KI polyomaviruses, coronaviruses, respiratory syncytial virus and parechovirus in children under 5 years of age in Tehran, Iran
Authors: Aghamirmohammadali Fahimeh Sadat , Sadeghi Kaveh , Shafiei-Jandaghi Nazanin Zahra , Khoban Zahra , Mokhtari-Azad Talat , Yavarian Jila
Published: April 2020

Background and Objectives: Severe acute respiratory infections (SARI) remain an important cause for childhood morbid- ity worldwide. We designed a research with the objective of finding the frequency of respiratory viruses, particularly WU and KI polyomaviruses (WUPyV & KIPyV), human coronaviruses (HCoVs), human respiratory syncytial virus (HRSV) and human parechovirus (HPeV) in hospitalized children who were influenza negative.
Materials and Methods: Throat swabs were collected from children younger than 5 years who have been hospitalized for
SARI and screened for WUPyV, KIPyV, HCoVs, HRSV and HPeV using Real time PCR.
Results: A viral pathogen was identified in 23 (11.16%) of 206 hospitalized children with SARI. The rate of virus detection was considerably greater in infants <12 months (78.2%) than in older children (21.8%). The most frequently detected vi- ruses were HCoVs with 7.76% of positive cases followed by KIPyV (2%) and WUPyV (1.5%). No HPeV and HRSV were detected in this study.
Conclusion: This research shown respiratory viruses as causes of childhood acute respiratory infections, while as most of mentioned viruses usually causes mild respiratory diseases, their frequency might be higher in outpatient children. Mean- while as HRSV is really sensitive to inactivation due to environmental situations and its genome maybe degraded, then for future studies, we need to use fresh samples for HRSV detection. These findings addressed a need for more studies on viral respiratory tract infections to help public health.
Maternal Perinatal Outcomes Related to Advanced Maternal Age in Preeclampsia Pregnant Women
Authors: Tyas Bestari Dianing , Lestari Pudji , Aldika Akbar Muhammad Ilham
Published: April 2020

Objective: This study aims to analyze the effect of advanced maternal age (>35 years old) in maternal and perinatal outcomes of preeclampsia women.
Materials and methods: This is a retrospective cross-sectional study involved all women who were diagnosed with preeclampsia at Universitas Airlangga Hospital (Surabaya, Indonesia) between January 2016 until May 2017. The participant was divided into two groups based on maternal ages: the first group was women older than 35 years old (advanced maternal age - AMA), and the other group was 20-34 years old (reproductive age - RA). The primary outcomes of this study were the maternal and perinatal outcome.
Results: There were a total of 43 AMA preeclampsia women and 105 RA preeclampsia women. The AMA preeclampsia group had a higher proportion of poor maternal outcome (the occurence of any complication: pulmonary edema, HELLP syndrome, visual impairment, post partum hemorrhage, and eclampsia) compared to RA preeclampsia group (60,5% vs 33,3%, p = 0,002; OR 3,059, CI 1,469-6,371). There was no significant difference in the other maternal complications such as HELLP syndrome, pulmonary oedema, and eclampsia. The only difference was the occurrence of postpartum haemorrhage which was higher in the AMA group (16,3% vs 4,8%, p = 0,02; OR 3,889, CI 1,161-13,031). The prevalence of cesarean delivery was more common in AMA group (53,3% vs 28,6%, p = 0,004; OR 2.825, CI 1.380-5.988). The AMA preeclampsia women also had poorer perinatal outcomes compared to the RA group (81,4% vs 59%, p = 0,009; OR 3.034 CI 1.283-7.177). AMA women had a higher risk of perinatal complication such as prematurity (OR 3.266 CI 1.269-8.406), IUGR (OR 4.474 CI 1.019-19.634), asphyxia (OR 4.263 CI 2.004-9.069), and infection (OR 2.138 CI 1.040-4.393).
Conclusion: Advanced maternal age increases the risk of poorer maternal and neonatal outcomes in preeclampsia patients. The addition of advanced maternal ages in preeclampsia should raise the awareness of the health provider, tighter monitoring, complete screening and early intervention if needed to minimize the risk of complications.
Jarcho-Levin Syndrome: Two Consecutive Cases in the Same Family
Authors: Grigorios Patsouras , George Maroudias , Ioannis Saloum , Konstantinos Patsouras
Published: April 2020

Jarcho-Levin Syndrome was first defined in 1938 by Saul Jarcho and Paul Levin. In the medical literature Jarcho-Levin Syndrome has a variety of synonyms such as Spondylocostal dysplasia/Dysostosis, SCD, SCDO, Spondylothoracic dysplasia/Dysostosis and costovertebral dysplasia. For years the SCD and a similar disorder, spondylothoracic dysplasia, were considered the same disorder and referred as Jarcho-Levin Syndrome. Today we know that these two disorders are different clinical entities with different causes and that the term Jarcho-Levin Syndrome should be reserved for individuals with Spondylocostal dysplasia. Affected individuals with SCD have various abnormalities in the development of the spine and ribs. Due to these abnormalities they are more prone to develop thoracic insufficiency syndrome which may eventually lead to early neonatal death. In the current case report we describe two consecutive cases with SCD in the same family. In the case of a strong clinical suspicion from the findings of the ultrasound scan we should proceed to a molecular genetic diagnosis of a mutation in DLL3, MESP2, LFNG and HES7 gene by sequencing the entire coding area of the fetal DNA.
The Problems of Engineering Students’ Professional Identity
Authors: Sholina I.I. , Reprintseva N.A.
Published: April 2020

Engineering education at Ural Federal University has its traditions; one of them is the design of new programs for nascent industries and flexible adaptation to changes in the economy. It allows UrFU engineering programs not only to survive in the conditions of constant external and internal changes but also to remain highly demanded and competitive. The article describes the problems of the professional identity of students of engineering programs, organizational models and didactic techniques that ensure professionalization in the framework of the leading educational programs of the UrFU Engineering School, which have been tested as part of pilot training for undergraduate students in the program ”System Analysis and Management.” The results of the survey among students and graduates of the program, which was conducted in order to understand their professional identity and awareness of the choice of an educational program for obtaining a profession, are presented.
Keywords: Learning outcomes, CDIO initiative, benchmark, modeling, Industry 4.0, student-centered learning, internships, professional identity, efficiency
Hardware and Software Infrastructure of Digital Twin Technology
Authors: L.A Zakharov , L.A. Derksen
Published: April 2020

This article describes of hardware and software infrastructure that provides the implementation of digital double technology. The basic approaches to determining the technologies that make up the infrastructure for the implementation of the digital twin, as well as the benefits of implementing this technology are considered. The need for processing and storing big data, as well as the benefits of implementing this technology, is substantiated.
Keywords: digital twin, digital model, big data, product lifecycle, cyber-physical system, automation, machine learning, smart maintenance.
Possibilities of Developing of Metallurgical Data Dumps
Authors: Karelova R.A. , Gruzman V.M.
Published: April 2020

Data about the technological production characteristics are sent to the archive, where they will be stored for many years. However, the stored data contains many undisclosed links between technological factors and technical and economic production indicators. The article presents a hypothesis about the possibility of processing data generated during production processes of industrial enterprises by analogy developing mining and physical dumps. The article provides an example of studying the sufficiency of the volume of a data metallurgical dump for constructing mathematical models using the experimental planning method. Samples from real production data dumps can compensate for the difficulties of implementing a modern active experiment in training future specialists in secondary vocational and higher education institutions. It is established that the data accumulated over the year in the production archive contain the necessary combinations of realizations of random variables for the two-factor model. The interval method of varying the levels of variables enables to construct an experimental matrix for a three-factor model as well.
Keywords: data dump, production data, metallurgical data, data analysis in metallurgy, matrix, mathematical planning, production management, model, model parameters identification, interval method.
Identify Compliance During Software Development Using System Engineering Principles
Authors: Tretyakov A.O. , Druzhinin M.V.
Published: April 2020

Errors made during the requirements collection and analysis phase make it very difficult to maintain the software product and cost the company extra costs. The difficulty of directly collecting requirements from stakeholders is due to inconsistencies between the major stakeholder groups, as well as related factors in the collection of requirements itself, as well as the selected methodology for the process of converting stakeholder requirements into development requirements. As a solution, it is necessary to use a high level of prioritization in order to distinguish among many requirements the necessary for successful implementation of the product, as well as to correctly allocate compliance with the requirements in such a way that each group of stakeholders is satisfied, but at the same time setting the goals of the supersystem more priority  than the goals of the subsystem. This article discusses the methodology of system engineering to solve issues related to the identification of possible contradictions of requirements.
Keywords: System engineering, requirements engineering, business process, requirements, software product, analysis.
Development of Requirements for a Multifunctional Chassis Machine Using System Engineering
Authors: Popov D. A.
Published: April 2020

The article describes how to properly formulate requirements when creating a product. Categories of requirements. Requirements management. Formation of the requirements of the source, target and system using system engineering using the example of a multifunctional chassis machine, the main subsystems of product requirements are also described.
Keywords: requirements, initial requirements, target requirements, system / subsystem requirements.
Implementation of MBSE Practices within Integrated PLM Solutions
Authors: Shcheinikov S.P.
Published: April 2020

The article provides a general analysis of the current state of information ecosystems that implement the practice of model-based system engineering. It is concluded that the largest players of the PLM-market in the strategy and tactics of development of their products lay support practices model-based system engineering. Implementation of MBSE practices within PLM solutions is considered on the example of Siemens Digital Industries Software’s products.
Keywords: System Engineering, Model-based system engineering (MBSE), Product lifecycle management (PLM), Capella, Modeling Tool, ARCADIA.
System Engineering for Project Organization
Authors: Ryabchikov O.N. , Shamanin A.Yu. , Aytbaev B.Kh.
Published: April 2020

The theory of systems allows to organize to more efficient management of the development and changes of the project. Classification of M. Jackson for classification of various practices of the systems approach was used for research and analysis. The paper deals with the use of systematic approach in organization management  to enhance efficiency in project progress and change management. Based on the classification of M. Jackson different applications of systematic approach are examined and analyzed. A case study of soft system thinking is described. The goal of ongoing research is development of a method to evaluate the effectiveness of project teams at HES MEPhI. The efforts involved application of soft systems methodology and yielded a unified methodology comprising tools and approaches of more efficient management of project teams. The merger of the soft systems methodology and evolution of developed tools into a combined methodology, its deployment in the practice of managing project teams in the field of education provides the launching site for its further extrapolation to other fields where project teams operate.
Keywords: system approach, project teams, education, soft systems thinking, organizational cybernetics, changes, management, efficiency, project, team
The System for Developing New Products at a Machine-building Enterprise Using System Engineering Techniques (For Example, PJSC MZIK)
Authors: Solopov A.Yu.
Published: April 2020

This article describes the problem of the task of finding and developing a new product in the conditions of a machine-building enterprise, as well as the vision of solving this problem (organization of works on search of ideas and development of a new product within the life cycle of the product at the machine-building plant named after M.I. Kinin). The picture of the task as a whole - on creation of an effective system of product support according to the life cycle is described. Technical and project processes are also considered as they are seen for implementation according to GOST 15288.
Keywords: product life cycle, requirements engineering, requirements verification, competence, production.
Examination in terms of accessibility and use of place of Unimpeded Wellness Center: The Case of Ankara
Authors: ÇETİNKALE DEMİRKAN Gülbin
Published: April 2020

Objective: Cities represent spaces where individuals with different characteristics live together. Amongst these individuals, there are people who have permanent disabilities and people who sometimes have disabilities. People with disabilities may not be able to adapt to the needs of normal life, such as healthy people. For this reason, various arrangements should be made in open and closed spaces in order to enable individuals with disabilities to act independently. Thus, participation of disabled individuals in social life will also be ensured. In our country, there are facilities and practices with certain support and arrangements that provide service for the disabled. In this study, the compliance of one of these facilities with the standards in terms of field usage was investigated.Material and Metod: Within the scope of this study, open for the use of disabled people and their attendants, “Ankara Sacettin Gürbüz Unimpeded Wellness, Special Education and Rehabilitation Center” was examined. Forming the physical environment of the center, the interiors of the building, the open green areas and their transition areas were examined within the framework of unimpeded space design. Accordingly, the current situation analysis was conducted in indoor and outdoor areas of the center in terms of size-dimension, unimpeded and sufficient area, surface quality, directives and warnings. The results obtained were examined in terms of “Basic Accessibility Handbook for Local Governments”, “The Guide for Universal Standards for Disabled” and “Turkish Standards Institution’s (TSI) Standards” in order to support accessibility and use.Findings: In the facility, roads, ramps, staircases, children’s playgrounds, play equipment, sports fields and equipments, surface coatings, sing and symbol, lighting elements and trash cans are found to meet the standarts. But, it is found that they are not positioned in the resting pockets, and some of the equipment elements are not ergonomic for the disabled.Results: As a result of the evaluation of the study findings using standards, it was determined that there is not a big problem in the facility for the disabled individuals while they are using it. In our country, increasing the number of qualified facilities such as Ankara Sacettin Gürbüz Unimpeded Wellness, Special Education and Rehabilitatio
Etlik Piliç Üretiminde Simbiyotik İlaveli Civciv Maması (Sulandırılmış Besin Takviyesi) Kullanımının Performans, Besin Madde Sindirilebilirliği, Bağışıklık Sistemi ve Kesim Özellikleri Üzerine Etkileri
Authors: YAZAR GÜNEŞ Hilal , AÇIKGÖZ Zümrüt
Published: April 2020

Amaç: Bu çalışmada, kuluçkadan çıkan civcivlere ilk 24 veya 48 saatlik periyotta simbiyotik ilaveli civciv maması (SCM) (sulandırılmış besin takviyesi) uygulamasının performans, kesim özellikleri, besin madde sindirilebilirliği ve bağışıklık sistemi üzerine etkileri incelenmiştir.Materyal ve Yöntem: Toplam 64 adet günlük erkek ve dişi etlik civciv (Ross 308) kullanılmıştır. Civcivler rastgele 4 deneme grubuna (8 erkek+8 dişi/grup) ayrılmıştır. Bunlar; Grup 1: ilk 24 saat civcivlere yem ve içme suyu verilmemiştir, Grup 2: ilk 24 saat civcivler yalnızca SCM ile beslenmiştir, Grup 3: ilk 48 saat civcivlere yem ve içme suyu verilmemiştir ve Grup 4: ilk 48 saat civcivler yalnızca SCM ile beslenmiştir.Bulgular: SCM uygulaması kesim canlı ağırlığı, yem tüketimi ve yemden yararlanma oranını etkilememiştir. Açlık süresi uzadığında karın içi yağı miktarı ve nispi ağırlığı azalmıştır, ancak SCM uygulaması bu özellikleri etkilememiştir. İlk 24 ve 48 saat SCM kullanılan gruplarda (2 ve 4) sırasıyla taşlık ve bezel mide nispi ağırlıkları artmıştır. İlk 24 saat SCM kullanılmayan Grup 1, diğer deneme gruplarına göre organik maddelerden ve ham proteinden daha iyi yararlanmıştır. Serum IgA seviyesi ilk 24 saat SCM kullanılmayan ve kullanılan gruplarda (1 ve 2) önemli düzeyde artmıştır. Serum IgM seviyesi ilk 48 saat SCM ile beslenen Grup 3’de yükselmiştir.Sonuç: SCM uygulaması bezel mide ve taşlık gelişimlerini olumlu etkilemiştir.
Prevalencia del uso indebido de alcohol y drogas psicoactivas en un instituto técnico de la ciudad de Babahoyo-Ecuador
Authors: Flores Moran John
Published: April 2020

Se presenta los resultados del estudio descriptivo de prevalencia de alcohol y drogas psicoactivas, en una muestra de 278 estudiantes entre las edades de 14 a 17 años que estudiaban en jornadas matutina y vespertina del Instituto Técnico Eugenio Espejo durante el año lectivo 2011-2012, y se realizó con financiamiento de la Universidad Técnica de Babahoyo, Ecuador. Se aplicó un cuestionario impersonal, similar al utilizado por el Sistema de Datos Uniformes del Observatorio Interamericano de Drogas, con la finalidad de conocer los niveles de prevalencia de vida, del último año y los recientes 30 días. Se encontró que el alcohol fue la sustancia de mayor nivel de consumo. Además, se estudió la presencia de factores de protección ante el consumo de sustancias, relacionados con la preocupación de los padres por la marcha de los estudiantes, y el control que ejercían cuando estaban en casa. Así mismo, se estudió la percepción de riesgo de los estudiantes y sus posibilidades de consumo.
Predictive Simulation of Concurrent Debris Flow: How Slope Failure Locations Affect Predicted Damage
Authors: Yamanoi Kazuki , Oishi Satoru , Kawaike Kenji , Nakagawa Hajime
Published: April 2020

Predictive simulation of concurrent debris flow using only pre-disaster information has proven to be difficult as a result of problems in predicting the location of debris-flow initiation (i.e., slope failure). However, because catchment topography has concave characteristics, with all channels in a catchment joining each other as they flow downstream, it is possible to predict damage to downstream area using relatively inaccurate initiation points. Based on this, this paper presents methodologies employing debris-flow initiation points generated randomly using statistical slope failure prediction. A many-case simulation across numerous initiation points was performed to quantify the effect of slope-failure location in terms of deviations in the predicted water level and terrain deformation. It was found that the relative standard deviation diminished as the points approached the downstream area, indicating a location-based predictability effect.