bluuebunny/crossref_metadata_2025 huggingface dataset:
Alterations of The Stem-Like Properties in The Breast Cancer Cell Line MDA-MB-231 Induced by Single Pulsed Doxorubicin Treatment
Authors: Pirsko Valdis , Čakstiņa Inese , Nitiša Dina , Samoviča Marija , Daneberga Zanda , Miklaševičs Edvīns
Published: April 2019

Development of chemoresistance remains a significant limitation for the treatment of cancer and contributes to recurrence of the disease. Both intrinsic and acquired mechanisms of chemoresistance are characteristics of cancer stem cells (CSCs) or stem-like cells (SLCs). The aim of the study was to assess the stem-like properties in the breast cancer cell line MDA-MB-231 during and after pulsed treatment with doxorubicin (DOX) in comparison to the untreated controls.The experimental cultures were exposed to therapeutic concentration of DOX for 48 hours (treatment cultures), and subcultured to post-treatment cultures 24 hours after the removal of DOX. Stem-like properties of the cellular populations in the treatment and post--treatment cultures were assessed by the expression of the stem-cell marker genes (CD24, CD44, ITGA6, ITGB1, POU5F1, NANOG, ALDH1A1), colony-formation efficiency, growth rates, and sensitivity to DOX, 5-fluorouracil (5FU), cisplatin (CIS), and vinblastine (VBL). Exposure to DOX induced formation of giant polyploid cells that persisted in the post-treatment culture. The recovery period was characterised by a decrease in the proliferation rate, viability, and cellular adherence. The post-treatment cultures displayed decreased sensitivity to DOX and increased sensitivities to 5FU, CIS, and VBL. Cells treated with DOX displayed increased expression levels of CD24, CD44, and ALDH1A, while their expression levels at least partially normalised in the post-treatment culture. The post-treatment cultures demonstrated significantly increased colony-formation ability. During treatment with sub-lethal levels of doxorubicin and during the acute recovery period, the survival mechanisms in the breast cancer cell line MDA-MB-231 may be mediated by formation of the cellular population with stem-like properties.
Coping with Febrile Illness in Children: A Qualitative Interview Study of Parents
Authors: Urbāne Urzula Nora , Gaidule-Logina Dita , Gardovska Dace , Pavāre Jana
Published: April 2019

The aim of this study was to investigate parental perception of febrile illness in their children, the most commonly applied management practices, as well as the expectations from clinicians when coping with fever in children. The study included parents of patients admitted to the Emergency and Observation Department of Children’s Clinical University Hospital in Rīga, Latvia. Data were collected via semi-structured interviews. All interviews were transcribed, and the transcripts analysed by inductive thematic analysis. Thirty-four parental interviews were analysed. Six themes emerged from the study, which were: signs causing concern; beliefs regarding fever; assessment and monitoring of fever; fever management practices; help-seeking behaviour; and expectations from the healthcare personnel. Many parents believed that fever could potentially cause injuries to the nervous system, kidneys, the brain, other internal organs, and even cause death. The perceived threat of fever resulted in frequent temperature measurements and administration of antipyretics. Meeting the emotional and information needs of the parents were considered as equally important to meeting the child’s medical needs. The study found that fever phobia exists among parents. Parental misconceptions of fever lead to overly zealous management practices. Parental education initiatives must be organised in order to improve parental knowledge of fever and its management in children.
A Pilot Study on Markers of Genetic Predisposition in Tuberculous Pneumonia Patients In Latgale
Authors: Kramiča Ksenija , Eglīte Jeļena , Koļesovs Aleksandrs , Kramiča Tatjana , Titoviča Gaļina , Džeriņa Diāna , Nikolajeva Glafira , Vīksna Ludmila , Koļesova Oksana
Published: April 2019

Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. HLA-DRB1*07 and HLA-DRB1*11 alleles were identified as risk alleles for TB. HLA-DRB1*15 allele was a protective allele. Due to the limitations of this exploratory study, a broader study needs to be conducted to revealing specific risk and protective HLA Class II alleles for TB in the subpopulation of Latgale.
«The Three Seas Initiative»: Perspectives of Energy Sector Development within the Croatian Foreign Policy
Authors: Zubovic M.
Published: April 2019

The article revolves around the Three Seas Initiative, a project launched in 2015 by the Republic of Croatia and the Republic of Poland, aimed at the development of cooperation and international relations between its 12 member states in the sphere of energy, digitalization and transport. Special emphasis is put on the development of Croatia’s foreign policy in the energy sector within the aforementioned Initiative, which can be achieved through the country’s participation in the construction of an LNG terminal on the island of Krk in Croatia. Moreover, both positive and negative aspects of the Initiative are presented in the article, considering the fact it has attracted not only the attention of western EU countries, but also the United States and Russia. Croatia’s participation in the projects of the Three Seas Initiative as one of its founders is considered to be one of the biggest steps in the country’s recent foreign policy, and if successfully put into practice, the Initiative could provide Croatia an opportunity to strengthen its geopolitical position in Europe.
OPETUSKOKEMUKSIA VERKOSSA – TIIMIOPETUKSELLA TULOKSIIN
Authors: Hartikainen Kaisa , Rissanen Tuula , Rosti Tomi
Published: April 2019

Itä-Suomen yliopiston jatko-opiskelijoiden tiedonhaun opetus kaipasi uusia sisältöjä ja päivitettyjä opetusmenetelmiä. Kun kirjaston tutkimuksen tuen palveluja kehitettiin, samalla rakennettiin Research Information Retrieval and Management (tutkimuksen tiedonhaku ja -hallinta) -opintojaksolle uudella konseptilla teemat. Artikkelissa kerromme opettajanäkökulmasta kokemuksia uudella tavalla toteutetulla, moduulirakenteisella, etäopetukseen ja itsenäiseen opiskeluun painottuvalla opintojaksolla sekä tiimiopettajuudesta opintojakson osana.
AVOIN TIEDE ESPANJASSA
Authors: Saarti Jarmo
Published: April 2019

Avoimen tieteen eurooppalaiset käytänteet ovat alkaneet muodostua nopeasti viime vuosina, kun Euroopan komissio ja erilaiset työryhmät ovat saaneet poliittista ja käytännön työtä eteenpäin. Vierailin viime vuoden lopulla Barcelonassa Erasmus-vaihdossa. Tavoitteenani oli haastatella paikallisia kollegoita ja oppia tutkimuksen avaamiseen liittyvistä tavoitteista ja toimintatavoista.
STRATEGI PENGEMBANGAN PRODUK SUSU KEDELAI DENGAN PENENTUAN KARAKTERISTIK PRODUK
Authors: Trisna Trisna , Maarif M. Syamsul , Arkeman Yandra
Published: April 2019

The aim of this paper is to descripe how a knowledge management plays a role in thedevelopment of new products with the determining of soy milk consumer characteristics andproduct characteristics by Kano method. Knowledge is a basic in decision making for newproduct development. Analysis conducted for costomer characteristic determination bydetermining costumer atribute influence buying decision and costomer clasification. Productcharacteristic in this paper uses Kano Method. The result of analysis of product characteristicshowed that halal labeling, soybean picture in packaging, inclusion of business address, ,inclusion of nutrient information, medium sweetness level are characteristic required to newproduct development of soy milk.
PENINGKATAN KAPASITAS PRODUKSI MELALUI PENERAPAN THEORY OF CONSTRAINT, PENJADWALAN MESIN PARALEL DAN BOTTLENECK SCHEDULING PADA PERUSAHAAN SHEET METAL WORK
Authors: Suci Sonia Nur Indah , Azmi Nora , Batubara Sumiharni
Published: April 2019

This study aims to increase the production capacity of the server rack 08U Type Double ASeriesWallmounted BRI on company X. Current production did not reached the expected target of117 units / week because of the bottleneck workstation. The study began by identifying the bottleneckworkstation using the Theory of Constraints (TOC). The result of identification process showed twobottleneck work stations, that are work station Punching and Ovencoating. The production capacitywas improved by performing the steps as follows: 1) Add 1 machine at punching station, 2) performjob scheduling on parallel machines at punching station using Short Processing Time (SPT) criteria;3) perform job sequencing on bending station using Weighted Shortest Processing Time (WSPT)criteria; 4 ) adds overtime at ovencoating stations, and 5) implementing bottleneck scheduling methodto sequence all jobs. The Results of this study showed that makespan was reduced by 12.03% andproduction capacity increased by 41.9% so that the production target of 117% can be achieved.
EVALUASI DAN USULAN PERBAIKAN KESEIMBANGAN LINTASAN PRODUKSI UNTUK MENCAPAI TARGET PRODUKSI DENGAN PENDEKATAN SIMULASI PADA WORKSHOP 3 DI PT. FACO GLOBAL ENGINEERING
Authors: Primadhana Reza , Moengin Parwadi , Adisuwiryo Sucipto
Published: April 2019

PT. FACO Global Engineering is a national company that manufactures Transformer Tank.The problems that arise on the production floor in Workshop 3 is a common difficulty in achievingproduction targets precisely at the appointed time this problem may be related to its unbalancedproduction line .. Average yield Transformer Tank produced today is 1 unit per week, while theproduction target set is 2 units per week.The methodology used is to use the simulation. The data obtained was then calculated andanalyzed the workload of each station. Utility work station is currently the largest existing utilities inthe workstation and welding with a cutting wheel percentages respectively 91.65% and 76.45%. Forutility work station is the smallest percentage of work stations fullfitting with 3.76%. This can beovercome by the proposed model are given 6. Model 2 the best proposal is the transfer station operatorto work painting and cutting wheel 1 fullfitting operator work station to drilling.
PERENCANAAN DAN PENJADWALAN DISTRIBUSI USAHAUSAHA KONVEKSI DARI IKM DM MENGGUNAKAN METODE DISTRIBUTION RESOURCE PLANNING
Authors: Hidayat Syarif , Agustini Devi Utami , Nurhasanah Nunung , Putri Ajeng
Published: April 2019

In the face of free markets in Asia that will occur by 2015, many companies are
working to improve and enhance all aspects of its business. One improvement in terms of
the distribution system. IKM DM is a company engaged in the business of producing
apparel office for women. IKM DM does not have a location for the manufacture of its
products but the company has a partner that is 11 business locations convection which
helps in the production activities of the company. The company currently has not
implemented the planning of the number of units that should be in the order of
distribution and scheduling each period for each attempt of convection. Recently,
planning process only be conducted based on instinct of management and to the schedule
undetermined. Every convection only be given a time limit the delivery of goods so to the
warehouse IKM DM.
This research focuses on the planning and scheduling distribution efforts of
convection became a partner of the IKM DM using the Distribution Resource Planning
(DRP) and this study only deals with products of office trousers of IKM DM. Convection
that produce these products there was only 5 convection, namely convection alan,
bambang, kusnandi, noto, and rani. The result of the calculation of DRP shows schedule
distribution and the number of units of a product that must be submitted for each period.
Based on the recapitulation for 14 period obtained the result that convection alan do
order as many as 81,438 units, convection bambang as many as 18,625 units, convection
kusnandi as many as 89,265 units, convection noto as many as 48,768 units and
convection rani as many as 60,099 units.
PENINGKATAN MUTU KULIT KUE MOCHI PRODUK PADA INDUSTRI PANGAN DI SUKABUMI
Authors: Ariyanti Silvi , Yuliarty Popy
Published: April 2019

Adanya tantangan yang dihadapi industri Mochi di Sukabumi saat ini adalah persaingan
pasar Mochi yang terus berkembang dengan bertambahnya kompetitor baru yang
menawarkan mochi yang berasal dari Korea dan Jepang dengan kualitas dan rasa yang
lebih baik dari produk Mochi Sukabumi. Berdasarkan survey awal dan interview yang
telah dilakukan pada dua industri Mochi yang terdapat di Sukabumi, kekurangan dari
produk Mochi tersebut adalah tekstur dari adonan yang kurang baik dan ukuran yang
tidak seragam. Adapun Tujuan dari penelitian ini adalah menghasilkan rancang bangun
mesin pengaduk pada proses pengadukan adonan kulit Mochi sehingga dengan mesin ini
dapat memperbaiki tekstur dari kulit Mochi yaitu lebih lembut dan halus. Setelah
dilakukan Implementasi dengan menggunakan mesin mengaduk adonan Mochi adonan
menjadi lebih baik dan kelelahan pekerja dalam proses pengadukan adonan kulit Mochi
dapat dihilangkan.
EVALUASI DAN USULAN PERBAIKAN KAPASITAS PRODUKSI UNTUK MENCAPAI TARGET PRODUKSI MENGGUNAKAN METODE THEORY OF CONSTRAINTS DAN SIMULASI
Authors: Paune Jessica , Moengin Parwadi
Published: April 2019

PT. Topjaya Antariksa Electronics merupakan perusahaan yang bergerak dalam industri
manufaktur dan distribusi peralatan rumah tangga. Produk yang diteliti adalah produk utama yang
dihasilkan PT. Topjaya Antariksa Electronics yaitu lemari es (refrigerator). Permasalahan yang
dialami oleh perusahaan adalah kapasitas produksi yang kurang memadai untuk mencapai target
produksi yang ditentukan. Tujuan dari penelitian ini adalah untuk melakukan evaluasi dan memberikan
usulan perbaikan kapasitas produksi untuk mencapai target produksi pada divisi final shop. Target
produksi untuk produk lemari es (refrigerator) perminggunya adalah sebanyak 6890 unit, sedangkan
hasil produksi pada saat ini adalah sebanyak 5671 unit/minggu.
Metode yang digunakan dalam penelitian ini adalah Theory Of Constraints dan Simulasi. Data
– data yang digunakan didapat dari hasil pengamatan dan wawancara yang telah dilakukan di divisi
final shop. Data hasil pengamatan yang ada diuji keseragaman dan kecukupan data sehingga
dihasilkan 15 data waktu pengamatan untuk waktu proses produksi. Data waktu tersebut digunakan
pada perhitungan Theory Of Constraints yaitu untuk mengetahui area/stasiun kerja yang mengalami
bottleneck. Dari hasil perhitungan Theory Of Constraints menunjukkan area bending, area caping,
area relay dan area ass door mengalami bottleneck yaitu dengan kurangnya 1 operator pada masing
– masing area tersebut, sedangkan area compressor dan area capilary yang merupakan area nonbottleneck
memiliki kelebihan 2 operator dan 1 operator. Hasil perhitungan Theory Of Constraints
akan menjadi dasar dalam membangun model usulan dengan menggunakan simulasi.
Dalam simulasi langkah awal yang dilakukan adalah membangun model yang
menggambarkan kondisi awal lantai produksi. Hasil output simulasi model awal menghasilkan 5671
unit/minggu. Setelah itu dilakukan pengembangan model-model scenario dari semua kemungkinan
sebagai pertimbangan model usulan. Dari 11 skenario yang ada didapat 5 model usulan. Dari kelima
model usulan yang ada dilakukan uji bonferroni untuk mengetahui apakah hasil output dan persentase
utilitas antara model usulan yang ada berbeda signifikan atau tidak. Dari hasil tersebut dapat
disimpulkan model usulan terbaik yaitu model usulan V yaitu dengan melakukan penambahan 1
operator baru pada area bending dan melakukan pemindahan 2 operator pada area compressor yaitu
1 operator pada area caping dan 1 operator pada area relay serta melakukan pemindahan 1 operator
dari area capillary ke area ass door. Pada model usulan V ini menghasilkan output produksi sebanyak
8387 unit/minggu dengan persentase utilitas operator sebesar 78.01%.
PENINGKATAN PRODUKTIVITAS ALAT MUAT SEKELAS OHT CAT 777 DI PERTAMBANGAN BATUBARA DENGAN PENDEKATAN QUALITY CONTROL CIRCLE
Authors: Nuryono Arif , Sjarifudin Didin , Ahmad Qadhi
Published: April 2019

PT Riung Mitra Lestari trying to improve the main load tool off high way truck (OHT) from one of their
job site dari salah satu job site owned PT. RML, Job Site Krassi, North Kalimantan where data showed
gains in productivity tools primarily under standard load. In January – August 2015 trend of
productivity gains is 83%. Krassi site that has the most difficult locations and conditions of 80% peat
land. With the location With a location 80% peat into one unique in handling dan its mining methods.
Research conducted using the QCC method to improved productivity mining equipment. Improvement
group is often called QCC uses severeal tools improvement and productivity improvement measures.In
the analysis of the probem or step 3 there are several causes at the root of the problem of inaccesibility
Cat hauler unit 777. In actual achievement prior to productivity improvement tool hauler Cat 777 is 78
bcm / hour of a target of 100 bcm / hour.In percentage only reaches 78% and the target after QCC
application is expected to reach 95%. Based on fishbone and pareto analysis major problem and the
dominant causes of the failure in the productivity tool loading and unloading is less good technique,
the second is the lack of a hard material that serves as mixing and blending. By making improvement
in loading technique and road repair there is productivity improvement 57,3 % dari from previous data
and 22,8 % improvement from target. The other factor that affected incapability of production is loss
time. After QCC improvement loss time decreased into 90,14 minutes per days from previously 227,14
minutes / days.
PENGENDALIAN PERSEDIAAN MELALUI PENENTUAN PRODUK STRATEGI
Authors: Dzikrillah Nurul , Purba Humiras Hardi , Suwazan Dhonny , Wahjoedi Noer
Published: April 2019

Fokus utama pada pemenuhuan kebutuhan pelanggan saat ini adalah pebaikan kualitas terusmenerus
dan pengendalian biaya. Persediaan yang tersimpan dalam jumlah besar hanya akan
berakhir sebagai pemborosan. Memilih kebijakan yang tepat dan mempertahankan
optimalnya tingkat persediaan merupakan tanggungjawab personel PPIC dalam menjaga
kestabilannya. Pemilihan kebijakan persediaan adalah sangat penting dalam menghadapi
persaingan global yang intensif dan dinamis. Penelitian kali ini bertujuan untuk mengurangi
nilai persediaan melalui penetapan strategi produk. Peneliti mengusulkan klasifikasi model
persediaan berdasarkan perencanaan produksi dan demand pasar. Hasil yang didapat adalah
nilai persediaan menurun tiap bulannya secara stabil dengan nilai persediaan untuk akhir
tahun pada saat melakukan perhitungan inventory projection adalah sebesar 11.3 juta USD
dimana mencapai target yang ditetapkan perusahaan yaitu sebesar 11.5 juta USD. Dan nilai
DIO pada akhir tahun menjadi 75 hari.
PENGARUH WARNA DAN GAMBAR TERHADAP TINGKAT RECOGNIZING DAN MATCHING SIMBOL VISUAL DI AREA PUBLIK
Authors: Peruba Lenka R. , Triyanti Vivi
Published: April 2019

Symbol is diagram or shape that represents an idea. Symbol should match to values with the intention to viewers can recognize it with no mistaken in interpretation. Therefore, recognizing and matching in interpreting symbol should be considered Conducting experimental designs, this research
concerns on 2 factors that predicted have certain relationship to recognizing and matching value of the symbol in public area, which are color and shape. The results showed the difference of colors and shape had significant effect in matching value. Mean while, only shape that had effect in recognizing value.
Symbol wirh color green had the highest matching value (1), where as symbol with white in black color has least matching value (0.525) Moreover, regression linear analysis using dummy variable indicates that person with lower age tend to have less recognizing capability than the younger one and male
generally had higher recognizing and matching value than female.
Anggota Dewan Redaksi
Authors: Moengin Parwadi
Published: April 2019

Anggota dewan redaksi
STRATEGI PERUSAHAAN BERDASARKAN ANALISIS RETURN SAHAM TERHADAP EPS, DER, ROA, PER, INFLASI, DAN BI RATE PADA SUB SEKTOR TELEKOMUNIKASI DI BURSA EFEK INDONESIA 2007-2015
Authors: Pratiwi Dhiana , Chumaidyah Endang , Zulbetti Rita
Published: April 2019

Sub sektor telekomunikasi merupakan industri yang memiliki pengaruh yang besar terhadap beberapa aspek, salah satunya aspek perekonomian. Tujuan dari penelitian ini untuk mengetahui pengaruh EPS, PER, DER, ROA, inflasi, dan BI Rate, secara simultan dan parsial terhadap return saham pada sub sektor telekomunikasi. Selain itu penelitian ini juga bertujuan untuk merumuskan strategi sub sektor telekomunikasi dalam meningkatkan performansi return saham setiap perusahaan. Sampel yang di gunakan adalah 5 perusahaan dari sub sektor telekomunikasi yang terdaftar di BEI selama periode 2007 sampai 2015. Data ini menggunakan data sekunder, dengan time series dan cross section dengan menggunakan regresi data panel.
EPS, PER, DER, ROA, inflasi, dan BI rate secara simultan memiliki pengaruh yang signifikan terhadap return saham. Sedangkan varibel yang memiliki pengaruh secara parsial terhadap return saham adalah ROA, dan inflasi. alat untuk merumuskan strategi adalah dengan membuat kuesioner AHP untuk ahli dan matriks SWOT.
PT Telkom Indonesia terpilih mewakili perusahaan sub sektor telekomunikasi untuk dilakukan analisa SWOT. PT Telkom Indonesia adalah perusahaan yang menunjukkan nilai pertumbuhan ROA serta rata-rata return saham paling baik karena ROA memiliki pengaruh terhadap return saham. Strategi yang dapat dilakukan perusahaan adalah strategi progresif, diharapkan perusahaan ini menjadi contoh bagi perusahaan sub sektor telekomunikasi dalam meningkatkan strategi perusahaan.
Cover Jurnal
Authors: Moengin Parwadi
Published: April 2019

Cover jurnal
SISTEM INFORMASI PERENCANAAN DAN PENGENDALIAN PERSEDIAAN BAHAN BAKU DI PT X
Authors: Christia Christia , Surjasa Dadang
Published: April 2019

PT X merupakan perusahaan yang bergerak di bidang manufaktur kapur barus atau kamper. Dalam pelaksanaan perusahaannya, diketahui di PT X belum memiliki metode terstandar dalam mengatur perencanaan, pengendalian serta penjadwalan tingkat kedatangan bahan baku, perencanaan dan penjadwalan biasanya dilakukan berdasarkan pengalaman dan perkiraan kepala bagian PPC saja sehingga perusahaan saat ini masih mengalami kendala dalam pengelolaan persediaannya, dimana bahan baku seringkali mengalami penumpukan di gudang. PT X juga masih menerapkan sistem manual dalam melakukan penjadwalan produksi dan pemesanan bahan bakunya. Berdasarkan permasalahan tersebut, maka dilakukan perancangan sistem informasi untuk merencanakan dan mengendalikan persediaan bahan baku di PT. X dengan menggunakan metode MRP (Material Requirement Planning). Serangkaian kegiatan yang dilakukan dalam metode MRP adalah melakukan peramalan penjualan, membuat MPS (Master Production Schedule), membuat BOM (Bill Of Material), menghitung kebutuhan bahan baku dengan metode lot sizing. Dengan adanya program aplikasi, maka akan mempermudah dan membantu pekerjaan Marketing, PPC dan gudang serta dapat membuat proses bisnis berjalan lebih cepat dan efisien.
USULAN PENERAPAN LEAN MANUFACTURING UNTUK MENGIDENTIFIKASI DAN MENGURANGI WASTE (STUDI KASUS PADA PT.X)
Authors: Amanda Fenny Joyanti , Doaly Carla Olyvia
Published: April 2019

PT. X adalah perusahaan yang bergerak di bidang produksi kapur barus, anti bau, dan serap air. Dalam pelaksanaannya, perusahaan perlu untuk terus meningkatkan kinerja produktivitas, kualitas, ketepatan waktu dalam pengiriman, serta berusaha menurunkan biaya. Untuk mencapai tujuan tersebut perusahaan perlu mengetahui aktivitas apa saja yang memberikan value added bagi produk, serta pemborosan apa saja yang sering terjadi dalam proses produksi. Oleh karena itu diperlukan suatu pendekatan lean manufacturing. Dengan strategi lean, perusahaan diharapkan mampu meningkatkan rasio value added produk serta mengurangi pemborosan. Pemahaman kondisi aktual perusahaan digambarkan dalam Current State Mapping. Pemborosan diidentifikasikan dengan delapan waste, kemudian dilakukan pembobotan secara detail dengan waste relationhip matrix (WRM) dan waste assessment quetionaire (WAQ). Setelah didapatkan hasil, dilakukan pemilihat tools dengan bantuan VALSAT dan dianalisa akar penyebab permasalahannya. Berdasarkan pengolahan data didapatkan 2 skor rata-rata tertinggi yaitu motion (21%), Defect (17.93%). Skor rata-rata pemborosan tersebut dikalikan dengan faktor pengali detail mapping, sehingga didapatkan detail mapping tools yang dominan adalah Process Activity Mapping (35.23%). Lead time dalam produksi kapur barus adalah 5127.36 menit, setelah usulan perbaikan dilaksanakan didapatkan lead time sebesar 1832.77 menit, dengan cara mengurangi waktu gerakan pada proses produksi dan pada defect dilakukan perbaikan SOP.
PERANCANGAN SISTEM PENDUKUNG KEPUTUSAN UNTUK PENGENDALIAN PERSEDIAAN BAHAN BAKU PADA PT. BATARASURA MULIA
Authors: Dwinanto Rafly , Moengin Parwadi , Adisuwiryo Sucipto
Published: April 2019

PT. Batarasura Mulia adalah sebuah perusahaan yang bergerak dibidang manufaktur. Perusahaan ini memproduksi berbagai macam jenis filter (penyaring) yang biasa digunakan didalam sebuah kendaraan bermotor seperti Fuel Filter, Oil Filter, dan Air Filter. Permasalahan yang dihadapi perusahaan adalah belum adanya sistem yang dapat mencatat pemesanan pelanggan dan mencatat pembiayaan pembelian bahan baku. PT. Batarasura Mulia masih menggunakan sistem yang manual. Perusahaan ini melakukan proses pembelian material dengan memperkirakan jumlah unit material berdasarkan jumlah unit material yang tersedia di gudang tanpa adanya proses perhitungan pembelian material terlebih dahulu. Hal tersebut mengakibatkan terjadinya keterlambatan proses produksi karena perusahan harus membeli sisa jumlah unit material yang kurang yang berada di gudang. Tujuan pada penelitian ini adalah merancang suatu sistem pendukung keputusan untuk pengendalian persediaan bahan baku yang dapat memberikan perhitungan berupa jumlah unit material yang dibutuhkan dan frekuensi pemesanan materialnya dengan menggunakan metode perhitungan Economic Order Quantity (EOQ) dan Period Order Quantity (POQ) serta menentukan metode yang terbaik yang akan digunakan berdasarkan biaya persediaan paling minimum. Perancangan sistem pendukung keputusan dimulai dengan melakukan analisis sistem yang sedang terjadi dengan menggunakan kerangka analisis PIECES (Performance, Information, Economics, Control, Efficiency, Services). Analisis dilakukan untuk mengetahui kebutuhan dari pengguna sistem. Kemudian langkah selanjutnya adalah melakukan perancangan komponen pengelolaan data dengan membuat diagram konteks, Data Flow Diagram (DFD), Entity Relationship Diagram (ERD), dan Physical Data Model (PDM). Perancangan sistem selanjutnya adalah merancang komponen pengelolaan model. Model yang digunakan dalam perancangan sistem pendukung keputusan adalah EOQ (Economic Order Quantity) dan POQ (Period Order Quantity). Perhitungan menggunakan model EOQ (Economic Order Quantity) dan POQ (Period Order Quantity) menghasilkan perhitungan jumlah unit pemesanan material yang dibutuhkan dan menghasilkan frekuensi pemesanannya. Langkah terakhir adalah perancangan user interface dengan menggunakan bahasa pemograman PHP. Hasil dari perancangan sistem pendukung keputusan menunjukkan bahwa sistem dapat memberikan perhitungan jumlah unit pemesanan material yang dibutuhkan dan frekuensi pemesanan setiap material berdasarkan model EOQ dan POQ serta dapat menentukan metode yang terbaik berdasarkan biaya persediaan yang paling minimum. Hasil dari penelitian ini adalah untuk model EOQ biaya total untuk seluruh bahan baku sebesar Rp257.333.000 dan untuk model POQ biaya total untuk seluruh bahan baku sebesar Rp132.756.200. Perancangan sistem pendukung keputusan ini ditujukan kepada departemen purchasing dan departemen inventory.
PENGEMBANGAN MODEL DETEKSI PELANGGARAN HUKUM DI LAUT
Authors: Sigit Wahyu , Daihani Dadan Umar , Surjasa Dadang
Published: April 2019

Indonesia merupakan negara kepulauan dengan 17.499 pulau, 5,9 juta km2 wilayah pesisir dan laut 81.000 km. Besarnya potensi sumber daya laut sangat melimpah sehingga terjadi eksploitasi dan kerugian lebih. Terdaftar sebagai sebuah kejahatan pada tahun 2015 dan sebanyak 235 negara berpenduduk 35 miliar kerugian pada tahun 2016. Sinergi Bakamla di era baru operasi keamanan maritim didukung oleh metode deteksi dan aktivitas intelijen. Penelitian ini difokuskan pada model pengembangan deteksi kejahatan di laut. Tujuan penelitian diperoleh model pendeteksian yang tepat untuk kelemahan dalam deteksi model saat ini. Deteksi aktivitas siklus intelijen terdiri dari pengumpulan data, pengolahan data, analisis, dan diseminasi. Sistem analisis saat ini belum menghasilkan identifikasi, pemetaan dan pemantauan kejahatan dan masih belum terintegrasi dengan sumber daya lainnya. Untuk mengetahui, pengembangan model deteksi akan menggunakan analisis tulang ikan untuk mengungkap penyebab tantangan analitis, organisasi dan birokrasi, bias informasi, kepemimpinan dan kebijakan inferior. Fokus penelitian dalam tantangan analitis adalah pendekatan sistem informasi geografis dalam fitur analisis spasial. Data awal akan dikonversi menjadi data spasial dalam pengumpulan data dan pengolahan data. Dengan menggunakan teknik visualisasi, kerapatan data kejahatan di laut akan diterapkan pada tahap analisis spasial. Untuk pendeteksian itu sendiri, pihaknya akan melakukan pemetaan kejahatan, kepadatan dan Voronoi. Skala kerapatan diilustrasikan dengan nuansa kuning (rendah) hingga merah (tinggi). Dengan demikian, chloropleth diperoleh (peta berwarna yang bervariasi sesuai skala kerapatan) berupa deteksi kejahatan merah (tinggi) di sektor 1B, 1E, 1F, 1G, 2H, 2J dan 2K pada tahun 2015. Model pendeteksian ini dilakukan. sebagai solusi dari masalah itu sebagai model pengembangan deteksi kejahatan di laut.
Enterogastric Reflux: an Uncommon Diagnosis Analyzed by Hepatobiliary Imaging
Authors: Wang Peter
Published: April 2019

Enterogastric reflux (EGR) is the reflux of bile and digestive enzymes from the small bowel into the stomach. While it is a normal physiologic process in small amounts, excessive reflux and chronic EGR can cause upper GI symptoms often mimicking more common diseases such as gallbladder disease and GERD that often leads to its underdiagnosis. Identifying EGR is significant as it has been associated with the development of gastroesophogeal pathology including gastritis, esophagitis, ulcers, and mucosal metaplasia. This article presents a 22-year-old male with enterogastric reflux causing upper abdominal pain and will discuss the role of hepatobiliary scintigraphy in its diagnosis.
A Complete experimental study of oil/water interfacial properties in the presence of TiO2 nanoparticles and different ions
Authors: Khalilnezhad Ali , Rezvani Hosein , Ganji Parastoo , Kazemzadeh Yousef
Published: April 2019

Previous studies on Nanoparticles (NPs) application for Enhanced Oil Recovery (EOR) methods have revealed their effective role in the rock wettability alteration, relative Interfacial Tension (IFT) and oil viscosity reduction, formation and stabilization of the emulsions, and reduced asphaltene precipitation, which are all in direct relationship with oil/water interfacial properties. This study focuses on the interfacial properties of oil/water in the presence of Titania NPs and different ions at different pressures and temperatures. For this, different concentrations of TiO2 NPs in the Formation Water (FW) were prepared to monitor the effects of NPs on the oil/water IFT, carbonate rock wettability, zeta potential, and asphaltene adsorption. The results on IFT values indicated that NPs behavior at high pressures and temperatures is completely different, as compared to the ambient conditions, and 1000 ppm NPs introduced the lowest IFT at 600 psi and 60 °C. This reduction is potentially attributed to the asphaltene adsorption at the oil/water interface by TiO2 NPs, which hinders the asphaltene deposition at the interface and in turn IFT increasing. Contact angle results revealed two distinctive behaviors for NPs at high and low concentrations. In other words, with the first interval (below the optimum concentration), an increase in NPs concentration led to a quick wettability alteration toward the water-wet condition, and with the second one (above the optimum concentration), there was an increase in contact angle with an increase in NPs concentration, which is due to the NPs stacking near the rock surface. These results were in good accordance with zeta potential measurements, in which 1000 ppm nanofluid presented the highest stability (zeta potential value of −46.9 mV). Batch adsorption experiments resulted that catalytic TiO2 NPs are capable of adsorbing asphaltene at the oil/water interface. In addition, the results on fitting experimental data to the Langmuir and Freundlich Isotherms showed that the adsorption best fitted Langmuir Isotherm and hence the adsorption type is a monolayer.
Evaluation of an uncertainty reduction methodology based on Iterative Sensitivity Analysis (ISA) applied to naturally fractured reservoirs
Authors: Costa Luís Augusto Nagasaki , Maschio Célio , Schiozer Denis José
Published: April 2019

History matching for naturally fractured reservoirs is challenging because of the complexity of flow behavior in the fracture-matrix combination. Calibrating these models in a history-matching procedure normally requires integration with geostatistical techniques (Big Loop, where the history matching is integrated to reservoir modeling) for proper model characterization. In problems involving complex reservoir models, it is common to apply techniques such as sensitivity analysis to evaluate and identify most influential attributes to focus the efforts on what most impact the response. Conventional Sensitivity Analysis (CSA), in which a subset of attributes is fixed at a unique value, may over-reduce the search space so that it might not be properly explored. An alternative is an Iterative Sensitivity Analysis (ISA), in which CSA is applied multiple times throughout the iterations. ISA follows three main steps: (a) CSA identifies Group i of influential attributes (i = 1, 2, 3, …, n); (b) reduce uncertainty of Group i, with other attributes with fixed values; and (c) return to step (a) and repeat the process. Conducting CSA multiple times allows the identification of influential attributes hidden by the high uncertainty of the most influential attributes. In this work, we assess three methods: Method 1 – ISA, Method 2 – CSA, and Method 3 – without sensitivity analysis, i.e., varying all uncertain attributes (larger searching space). Results showed that the number of simulation runs for Method 1 dropped 24% compared to Method 3 and 12% to Method 2 to reach a similar matching quality of acceptable models. In other words, Method 1 reached a similar quality of results with fewer simulations. Therefore, ISA can perform as good as CSA demanding fewer simulations. All three methods identified the same five most influential attributes of the initial 18. Even with many uncertain attributes, only a small percentage is responsible for most of the variability of responses. Also, their identification is essential for efficient history matching. For the case presented in this work, few fracture attributes were responsible for most of the variability of the responses.
Hollow Y zeolite single crystals: synthesis, characterization and activity in the hydroisomerization of n-hexadecane
Authors: Pagis Céline , Bouchy Christophe , Dodin Mathias , Martinez Franco Raquel , Farrusseng David , Tuel Alain
Published: April 2019

Hollow Y zeolite single crystals have been obtained from a conventional NaY zeolite following a three-step process involving a severe dealumination of the zeolite with silicon tetrachloride (step #1), followed by an acid washing under mild conditions (step #2) and finally a selective dissolution of the crystals core in the presence of protective Al species (step #3). Crystals are characterized by the presence of a regular internal cavity with 0.1–0.2 nm thick microporous walls. They contain a relatively low framework Al content but significant amounts of extraframework Al oxide species mainly located on the external surface of the crystals. Hollow crystals have been mixed with a Pt-supported alumina binder and used as catalysts in the hydroisomerization of n-hexadecane. Compared to the corresponding bulk crystals obtained after step #2, their higher activity has been attributed to a better efficiency, directly resulting from the presence of the cavity.
Örgütlerde Cam Tavan Sendromunun Örgütsel Güven Üzerine Etkisi: Lojistik Hizmet Sağlayıcılarına Yönelik Bir Araştırma
Authors: ÖRÜCÜ Edip , AKGÜL Görkem
Published: April 2019

Kadınlar, çalışma hayatındaki sayıları gün
geçtikçe artmasına rağmen, üst düzey yönetici pozisyonlarına ulaşmalarında
çeşitli engellerle karşılaşmaktadırlar. Bu çalışmada lojistik hizmet
sağlayıcılarında çalışan kadınların cam tavan sendromunun örgütsel güven
üzerine etkisinin belirlenmesi amaçlanmaktadır. Bu  bağlamda, mevcut alan yazına göre cam tavan
sendromu ve örgütsel güven kavramları açıklanmış ve aralarındaki ilişkiye yer
verilmiştir. Çalışmanın uygulama kısmında, lojistik hizmet sağlayıcılarında çalışan
kadınlara yönelik olarak anket yöntemi ile veri toplanmıştır. Yapılan analizler
sonucunda elde edilen bulgulara göre, cam tavan sendromunun örgütsel güven, yöneticiye
güven ve örgüte güven üzerinde anlamlı bir etkisi bulunmamaktadır.
Healing of Polymeric Solids by Supramolecular Means
Authors: Neumann Laura N. , Weder Christoph , Schrettl Stephen
Published: April 2019

Equipping a polymeric material with the ability to heal an inflicted damage is a crucial advantage for many applications. The incorporation of reversible and dynamic supramolecular interactions into polymeric systems has proven to be a promising route towards such materials. In this
article, recent developments in the field of healable materials are highlighted with a particular focus on the design principles, driving forces, and mechanisms that allow healing to occur.
A Diversity of Asymmetric Nano-/Microcolloidal Architectures Grown by ATRP from Janus Seeds
Authors: Kang Chengjun , Honciuc Andrei
Published: April 2019

The fabrication of colloids has witnessed significant progress during the last decade, however, fabrication of anisotropic colloidal particles with complex geometries still represents a challenging task. Here, we present nano-/micro-sized colloidal architectures which 'grow' directly
from nanoparticle seeds by controlled radical polymerization, resembling the growth of plants from seeds in the natural world. Specifically, we use the atom transfer radical polymerization (ATRP) technique to grow colloidal architectures from snowman-shaped Janus nanoparticle seeds (JNPS).
The key to this synthetic approach is the asymmetric placement of the ATRP initiators in the bulk of one JNPS lobe. By starting the polymerization, monomers continuously add to the initiator containing the JNPS lobe, which subsequently grows into a larger colloidal structure. By controlling
growth conditions mainly through the interaction strength between the monomer and JNPS, a variety of colloidal architectures result, for example, dish-, basket, cocoon-, flower-, helmet- mushroom-, dumpling and pumpkin-like geometries. Furthermore, each of these grown architectures have different
surface morphologies, including smooth-, island- and grouped island nanostructures. The present work provides an alternative method to the synthesis of anisotropic particles with complex geometries and tunable surface morphologies, thus enriching the toolbox for the colloid synthesis.
Bringing Biocatalysis into the Deuteration Toolbox
Authors: Rowbotham Jack , Lenz Oliver , Reeve Holly , Vincent Kylie
Published: April 2019

Chemicals labelled with the heavy hydrogen isotope deuterium (2H) have long been used in chemical and biochemical mechanistic studies, spectroscopy, and as analytical tracers. More recently, demonstration of selectively deuterated drug candidates that exhibit advantageous pharmacological traits has spurred innovations in metal-catalysed 2H insertion at targeted sites, but asymmetric deuteration remains a key challenge. Here we demonstrate an easy-to-implement biocatalytic deuteration strategy, achieving high chemo-, enantio- and isotopic selectivity, requiring only 2H2O (D2O) and unlabelled dihydrogen under ambient conditions. The vast library of enzymes established for NADH-dependent C=O, C=C, and C=N bond reductions have yet to appear in the toolbox of commonly employed 2H-labelling techniques due to requirements for suitable deuterated reducing equivalents. By facilitating transfer of deuterium atoms from 2H2O solvent to NAD+, with H2 gas as a clean reductant, we open up biocatalysis for asymmetric reductive deuteration as part of a synthetic pathway or in late stage functionalisation. We demonstrate enantioselective deuteration via ketone and alkene reductions and reductive amination, as well as exquisite chemo-control for deuteration of compounds with multiple unsaturated sites.
Analytical Derivatives of the Individual State Energies in Ensemble Density Functional Theory Method: II. Implementation on Graphical Processing Units (GPUs)
Authors: Liu Fang , Filatov Michael , Martínez Todd J.
Published: April 2019

Conical intersections control excited state reactivity and thus elucidation and prediction of their shapes and locations is crucial for photochemistry. To locate these intersections one needs accurate and efficient electronic structure methods. Unfortunately, the most accurate methods (e.g. XMS-CASPT2) are computationally difficult for large molecules. The state-interaction state-averaged restricted ensemble referenced Kohn-Sham (SI-SA-REKS) method is a computationally efficient alternative. The application of SI-SA-REKS to photochemistry was previously hampered by a lack of analytical nuclear gradients and nonadiabatic coupling matrix elements. We have recently derived analytical energy derivatives for the SI-SA-REKS method and implemented the method effectively on graphical processing units (GPUs). We demonstrate that our implementation gives the correct topography and energetics of conical intersections for several examples. Furthermore, our implementation of SI-SA-REKS is computationally efficient – the observed scaling with molecular size is sub-quadratic, i.e. O(N1.77). This demonstrates the promise of SI-SA-REKS for excited state dynamics of large molecular systems.
په‌سن وه‌ك ستراتیجیه‌ته‌كا ڕێزگرتنێ د زمانێ كوردیدا "ڤه‌كۆلینه‌كا پراگماتیكییه‌"
Authors: Ali Sherzad S.
Published: April 2019

په‌سن كرده‌یه‌كا گرنگه‌ ژ كرده‌یێن ئاخڤتنێ و دچیته‌ د ناڤ ئاستێ پراگماتیكێدا. ئه‌ڤ ڤه‌كۆلینه‌ هه‌ولدده‌ت ڤه‌كۆلینێ ل په‌سنێ وه‌كو ستراتیجیه‌ته‌كا ڕێزگرتنێ د زمانێ كوردیدا بكه‌ت، ئه‌وژى ب مه‌ره‌ما هندێ كا چه‌وا دێ دشیاندابیت په‌سنێ وه‌كو ستراتیجیه‌ته‌كا ڕێزگرتنێ ده‌ستنیشانبكه‌ین. ئه‌ڤ ڤه‌كۆلینه‌ ب ناڤونیشان:(په‌سن وه‌ك ستراتیجیه‌ته‌كا ڕێزگرتنێ د زمانێ كوردیدا )یه‌ ئه‌وژى د سنوورێ ئاخڤتنا خه‌لكێ گۆڤه‌را به‌هدینیدا، ئه‌ڤ ڤه‌كۆلینه‌ هه‌ولدده‌ت ڤه‌كۆلینێ ل په‌سنێ بكه‌ت، كا چه‌وا بۆ مه‌به‌ستا ڕێزگرتنا ئه‌رێنى و نه‌رێنى بكاردهێت. ڤه‌كۆلین ل دویڤ ڕێبازا وه‌سفى شیكاری هاتییه‌ ئه‌نجامدان. ئارمانجا سه‌ره‌كى ژ ئه‌ڤێ ڤه‌كۆلینێ ئه‌وه‌ بهێته‌ زانین، كا چه‌وا په‌سن دێ بیته‌ ستراتیجیه‌ته‌كا ڕێزگرتنێ یا ئه‌رێنى و چه‌وا دێ بیته‌ ستراتیجیه‌ته‌كا ڕێزگرتنێ یا نه‌رێنى. ئه‌ڤ ڤه‌كۆلینه‌ ژ دوو پشكان پێكدهێت، پشكا ئێكێ ب ناڤونیشان:(په‌سن و پراگماتیك)ه‌، كو تێدا ب شێوه‌كێ گشتى به‌حسێ چه‌مك و ئه‌ركێن په‌سنێ، په‌سن وه‌كو كرده‌یه‌كا ئاخڤتنێ، په‌سن و نفشى و پێكهاتا پراگماتیكییا په‌سنێ هاتییه‌ كرن و پشكا دووێ یا تایبه‌ته‌ ب (په‌سن وه‌كو ستراتیجه‌ته‌كا ڕێزگرتنێ).
Classifier Constructions in English and Kurdish
Authors: Sabir Anjuman M. , Kamal Dyar A.
Published: April 2019

Greenberg (1972) in a study based on a sample of about 100 languages with numeral classifiers, attempted to determine the conditions under which anon- classifier language might become a classifier language. Later Hale and Shresthachrya (1973) made their attempts to seek whether Newari is considered as a classifier language or not. The purpose of this study is to analyze the Kurdish classifier system based on the Greenberg (1972) whether Kurdish is a classifier language or not, the paper also compares classifier constructions in English and Kurdish, with the aim of addressing the research questions: what linguistic devices are used in Kurdish and English for classification? How different or similar are classifiers in Kurdish and English as non-classifier language. Classifiers in Kurdish have not been studied extensively and there are not any references available on classifiers of Kurdish in English. Therefore, by considering the classifier system of Kurdish, this study makes attempt to provide an introductory source of analytical research of grammar in Kurdish.
MEANINGS ATTRIBUTED BY NURSES TO COMBAT HOMOPHOBIA AND PREVENTION OF HOMOSEXUAL SUICIDE
Authors: Araujo Ellen Thallita Hill , Rodrigues Jnhessica Talita Da Silva , Carvalho Júnior José Arnaldo Moreira de , Sousa Geovani Ferreira de , Pessôa Francisco Gaunié de Sousa
Published: April 2019

Objective: to analyze the meanings attributed by primary care nurses about the fight against homophobia and suicide prevention among homosexuals. Method: descriptive and qualitative research performed with nurses who work in the Family Health Strategy of a city in Northeastern Brazil. A semi-structured script was used for interviews conducted in September and October 2018. The transcribed statements were processed in the IRaMuTeQ software and analyzed by the Descending Hierarchical Classification. Results: four classes were identified, named "Prevention of suicide among homosexuals in primary care", "Public policies focused on the homosexual population", "Reception of the homosexual population in primary care" and "Fighting homophobia in primary care" respectively. The meanings attributed by nurses were anchored in improving the reception of the lesbian, gay, bisexual, transvestite and transsexual population (LGBT). Conclusion: It is necessary to recognize the need to invest in studies that reinforce the expansion of humanized care and free of prejudice.
Editorial
Authors: Fernandes Karin Sá
Published: April 2019

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Expansão e disjunção palatina em pacientes classe III com uso de máscara facial
Authors: Suassuna Katia Maria De Lima , Santos Denis Clay Lopes , Negrete Daniel , Flaiban Everton , Santos Raquel Lopes dos , Bortolin Renata
Published: April 2019

O tratamento de má oclusão Classe III esquelética representa um grande desafio ao profissional. Quando a má oclusão de Classe III for determinada por uma retrusão maxilar, o tratamento ortopédico precoce é in­dicado, onde o tratamento de escolha é a disjunção palatina seguida do uso de máscaras faciais. O objetivo deste estudo é analisar e discutir fatores determinantes para o planejamento da expansão maxilar. A me­todologia utilizada foi de uma pesquisa bibliográfica, realizada na base de dados da SCIELO e LILACS. Os resultados mostraram que os fatores determinantes para o planejamento da expansão maxilar depende­rão do tempo do tratamento para se conseguirem resultados positivos, pois, variam muito, de acordo com as características da força empregada, tais como magnitude, direção e horas de uso; e as chances relação dos maxilares com o crânio, a dimensão vertical e a idade do paciente. Conclui-se que o uso da expansão rápida da maxila ou disjunção palatina associado à máscara facial é bastante eficaz no tratamento da má oclusão de Classe III em idade precoce.