bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Assignment and Socratic Methods on Students’ Achievement in Business Mathematics among Colleges of Education in North-Western Nigeria
Authors: Onaolapo Eniola , Sani Ibrahim , Umar Rahmat Talatu , Magaji Zakari Buba
Published: February 2025

The aim of the study was to find out the effect of assignments and Socratic methods on students’ achievement in business mathematics in colleges of education in north-west Nigeria. The research design adopted for this study was a quasi-experiment design. The population for the study comprises 684 business mathematics students for the 2022-2023 academic session. The purposeful sampling technique was used in the selection of the three colleges for the experiment. Mean, standard deviation, and mean difference were used to answer the three research questions. An independent t-test was used to test all the null hypotheses. Students taught business mathematics using the Socratic method performed better than those taught using the lecture teaching method. (P-value 0.000). Students taught business mathematics using the assignment method performed better than those taught using the conventional teaching method. (P-value 0.002). Students taught business mathematics using the Socratic method performed better than those taught using the assignment teaching method. (P-value 0.000). The findings revealed that the Socratic method is the more effective method of teaching business mathematics than the assignment, and conventional teaching methods had a significant effect on students’ achievement in business mathematics. Based on the findings, it was recommended that teachers of business mathematics should adopt the Socratic method in their classes because the method is capable of improving students learning outcomes.
Wujud Stigma Perempuan Dalam Seni Lukis Surealis
Authors: Prayoga Randi Rama , Karyono Tri
Published: February 2025

Penting untuk diingat bahwa stigma perempuan adalah isu kompleks yang terhubung dengan berbagai faktor sosial, budaya, ekonomi, dan politik serta kependidikan. Permasalahan yang sering diamali oleh perempuan, sedikit banyaknya juga penulis rasakan sendiri, diambang usia menuju kedewasaan banyak hal-hal baru yang menarik perhatian sehingga seringkalinya mengalami kesadaran dalam bagaimana masyarakat luas dalam memandang perempuan dalam suatu kotak pemahaman. Banyaknya pengaruh dari pola kehidupan manusia maupun lingkungan sosial seringkali membawa pengaruh bagi seseorang dalam memahami suatu problematika terutama dalam stigma perempuan, sehingga penulis ingin memberi ilustrasi dimana dapat menjadi pemahaman bersama bagaimana melepaskan perempuan dari belenggu stigma membutuhkan upaya kolektif dan berkelanjutan. Tahapan persiapan pembuatan karya ada lima tahap yaitu : (1) Persiapan (2) Elaborasi (3) Sintesis (4) Realisasi Konsep dan 5) Penyelesaian. Karya-karya ini membahas tentang perihal yang jarang dirasakan, serta dimiliki oleh setiap golongan masyarakat bagaimana menganggap perempuan itu memiliki derajat yang sama serta dapat membebaskan mereka dalam hal berekpresi tidak dibendungi oleh cibiran, makian bahkan kekerasan. Untuk itu dengan adanyanya karya-karya penulis harap untuk dapat menyadarkan ataupun hal-hal yang selama ini terjadi itu adalah salah terutama pada stigma perempuan dikehidupan sehari-hari. Menghapus stigma pendidikan perempuan tidak perlu tinggi, akan mempermudah dan membuka peluang bagi perempuan untuk mengembangkan dirinya.
Pekan Seni Grafis Yogyakarta Sebagai Praktik Budaya Produksi
Authors: Sasongko Damar , Nur Kamila Nisrina , Kaheqsi Ainur , Alfiandi Dimas , Rika Winata Caroline
Published: February 2025

Pekan Seni Grafis Yogyakarta (PSGY), diinisiasi oleh Grafis Minggiran, mempunyai peran penting dalam melestarikan dan mengembangkan seni cetak grafis di Indonesia. Berlangsung setiap dua tahun, PSGY menjadi ajang memperkenalkan seni grafis ke khalayak luas melalui pameran, workshop, seminar, residensi, dan perlombaan. PSGY dapat dikatakan turut memproduksi sebuah kebudayaan, yakni kebudayaan grafis yang dapat menginspirasi para seniman dan masyarakat luas terkait seni grafis. Penelitian ini berupaya mengungkap nilai-nilai serta artikulasi dari suatu budaya yang diproduksi oleh PSGY. Penelitian menggunakan metode kualitatif dan etnografi dengan pendekatan budaya produksi (culture of production) dari DuGay dan sirkuit budaya (Circuit of Culture) dari Stuart Hall. Melalui pembahasan yang dilakukan, didapat sepuluh nilai dalam PSGY, yakni informatif, edukatif, kolaboratif, nasionalisme, sejarah, kompetitif, dokumentasi, konsisten, inovatif, dan profesionalitas. Sementara produksi PSGY berartikulasi pada regulasi, konsumsi, dan representasi.
Anting Jepit Bunga Cosmos: Kreasi Perhiasan Berbahan Resin dan Bunga Kering
Authors: - Chici Yuliana Nadi
Published: February 2025

"Cosmos Flower Clip Earrings" are the creation of the Petrichor Project UMKM, which responds to consumer requests to create jewelry made from real flower petals. This research aims to determine the effect of differences in earring results using variations in UV (ultra violet) resin smeared techniques on pressed Cosmos flowers in the process of creating original flower petal earrings. The creation method used is an experimental method, with the independent variable being the UV resin application technique, and the dependent variable being pressed Cosmos flowers. The UV resin application technique is divided into two, namely the one-sided smeared technique and the two-sided cross smeared technique. The research data was then analyzed descriptively-qualitatively. There is a significant difference in the final result in the shape of the flower petals, where the one-sided smeared technique changes the shape of the flower petals from flat to curved. Both samples have the same luster, the flowers do not experience color deformation, and have good resistance to impact and scratches.
Makna Simbolis Topeng Malangan Lembu Suro Dalam Perspektif Semiotika Visual
Authors: Cerly Sudarta Martsidaun
Published: February 2025

The Lembu Suro Mask in the Topeng Malangan tradition is a cultural heritage that contains complex symbolism and deep mythological narratives. This research aims to explore the cultural meanings contained in the visual elements of the mask through Roland Barthes' visual semiotics approach. The analysis was conducted on the denotation and connotation aspects of elements such as color, shape, motif, and expression, and was linked to the Lembu Suro myth in the local tradition of the Malang community. Data were obtained through the observation of mask artifacts, performance art documentation, and interviews with traditional artists. The analysis results show that the red and black colors on the mask symbolize strength, protection, and bravery. The stern face shape with horns resembling a bull reflects characteristics of leadership, bravery, and spirituality. The visual ornaments adorning the mask reinforce its sacred function in rituals, while also serving as a link to the local narrative about the Lembu Suro myth, which emphasizes the values of loyalty, sacrifice, and cosmic harmony. This research asserts that the Lembu Suro Mask not only serves as a medium of aesthetic expression but also functions as a symbol of cultural identity and spirituality of the Malang community. This study contributes to the preservation of traditional craft arts and a deeper understanding of the importance of visual semiotics in representing local values.
The Kajian User Experience Media Literasi Visual Buku Cerita Anak Berbasis Augmented Reality
Authors: Putri Kinanti Erste Panggayuh , Deny Tri Ardiyanto
Published: February 2025

Virtual reality and the real world are combined in the Augmented Reality Children Storybook (ARCS), a visual literacy media of the Timun Mas folk tale. This study examines how parents and kindergarten instructors use ARCS Timun Mas, which uses augmented reality as a narrative tool for young children, in order to put the idea of smart education into practice. The case study explorative qualitative research method was used to dig deeper through the study of works and audience studies through the results of the User experience questionnaire (UEQ), which considers 6 measurement indicators (visual appeal, clarity of storyline, media efficiency, media reliability, technology simulation, and media novelty). The findings demonstrated that ARCS Timun Mas media has a lot of potential for use as a technology-based visual literacy media innovation in early childhood as a unit facility since it can offer a fresh, more engaging visual experience by combining visual illustrations, 3D animation, and audio narration. Further research suggestions can be carried out with direct involvement of children to examine the role of ARCS visual media in the formation of visual perception and reception of visual messages in the form of educational and moral values.
Tratamiento de aguas residuales para la comunidad Hualcanga San Luis, Cantón Quero, Provincia de Tungurahua
Authors: Núñez Aldás Galo Wilfrido , Frías Torres Alex Xavier , Guevara Robalino Jorge Javier , Lozada López Darwin Joel
Published: February 2025

Introducción.  El diseño del sistema de alcantarillado y la planta de tratamiento de aguas residuales para la comunidad Huancalga San Luis, en el cantón Quero, provincia de Tungurahua, surge como una solución a problemas ambientales y sanitarios recurrentes, tales como el colapso de alcantarillas, malos olores, obstrucción de redes y la propagación de enfermedades derivadas del manejo inadecuado de las aguas residuales. La comunidad enfrenta deficiencias en su infraestructura de saneamiento, lo que impacta negativamente en la salud pública y el medio ambiente. Objetivo. Este estudio se basa en un diagnóstico detallado de la situación actual de la comunidad, considerando su crecimiento poblacional, condiciones topográficas y características del suelo. A partir de este análisis, se busca diseñar un sistema de alcantarillado y una planta de tratamiento eficientes y sostenibles, que cumplan con las normativas vigentes y se adapten a las necesidades locales. La investigación incluye un marco teórico que abarca conceptos fundamentales sobre saneamiento, tratamiento de aguas residuales y normativas ambientales aplicables. Metodología. La metodología empleada involucra estudios de campo, levantamientos topográficos, análisis de caudales y calidad del agua, así como modelaciones hidráulicas para garantizar un diseño adecuado y funcional. Se consideran criterios técnicos para la selección de materiales, dimensionamiento de redes y tecnologías de tratamiento que permitan la depuración eficaz de las aguas residuales antes de su disposición final. Resultados. Los resultados esperados incluyen la reducción de la contaminación ambiental, la mitigación de riesgos sanitarios, la mejora en la calidad de vida de los habitantes y el cumplimiento de normativas técnicas. La implementación de esta infraestructura contribuirá al desarrollo sostenible de la comunidad, asegurando un manejo adecuado de las aguas residuales y promoviendo un entorno más saludable. Conclusión. La implementación del sistema de alcantarillado y la planta de tratamiento mejorará la calidad de vida en Huancalga San Luis, reduciendo la contaminación y los riesgos sanitarios. Este proyecto garantiza un manejo eficiente y sostenible de las aguas residuales, promoviendo un entorno más saludable. Área de estudio general: Saneamiento ambiental. Área de estudio específica: Tratamiento de aguas residuales. Tipo de estudio:  Artículos originales.
Modified atmosphere packaging with gamma irradiation extending shelf life of strawberry ‘CV’ winter dawn
Authors: Saran F Y , Hassan M K , Akhther N
Published: February 2025

An experiment was carried out at the Postharvest Laboratory of the Department of Horticulture, Bangladesh Agricultural University, Mymensingh during the period of February to March, 2023 to find the effects of different postharvest treatments on shelf life and quality of strawberry. The experiment was laid out in completely randomized designs with three replications. There were five treatments, viz. T0: Control (non-irradiated unwrapped), T1: 2.0 KGy gamma irradiated fruits held in 25μ polypropylene bag, T2: 2.0 KGy gamma irradiated fruits held in ambient condition, T3: 2.0 KGy irradiated fruits wrapped in 25μ low-density poly ethylene bag, T4: 2.0 KGy irradiated fruits wrapped in 25μ high-density poly ethylene bag. Data were recorded on weight loss, firmness, color, flavor, shrinkage, freshness, appearance, diseases severity and shelf life at different days after storage.  The minimum weight loss (0.73%) was found in 2.0 KGy gamma irradiated fruits wrapped in 25μ polypropylene bag and the maximum weight loss (3.44%) in untreated control strawberry. The longest shelf life (4.0 days) was recorded in 2.0 KGy irradiated fruits held in 25μ polypropylene bag, fruits and the shortest shelf life (3.0 days) was found in untreated control fruits.  The findings would greatly contribute to reducing postharvest loss of strawberry and maintaining their quality during storage and marketing at ambient conditions.
Bangladesh J. Nuclear Agric, 38(2): 15-25, 2024
Profitability and yield gap analysis of Binadhan-14 in some selected areas of Bangladesh
Authors: Sarkar M M A , Rahman M H , Islam S , Sultana R
Published: February 2025

The aim of this study was to estimate the profitability and yield gap of Binadhan-14 and to suggest some policy guidelines to minimize the yield gap. The study was conducted in Mymensingh, Jamalpur, Rangpur and Sunamganj districts of Bangladesh. Data were collected using a simple random sampling technique from 200 Binadhan-14 cultivating farmers. Data were collected through pre-designed interview schedule from October-November, 2021 for achieving the purpose. Descriptive statistics techniques as well as Stochastic Frontier model were used to achieve the objectives of the study. The average actual farmer’s yield of Binadhan-14 was 5.11 t ha-1. BCR was estimated at 1.53 implying that the Binadhan-14 cultivation at farm level was profitable. The estimated average yield gap-I was 0.43 t ha-1 (6.95 %.) and average yield gap-II was 0.71 t ha-1(12.10 %.). The average yield gap was 1.14 t ha-1 (19.05%). The farmers among the study areas did not consider the recommended doses of seed rate and fertilizers. The regression coefficients for power tiller, human labor, fertilizers, irrigation, wedding, insecticides and seed for Binadhan-14 under all areas were positive and significant at 1%, 5% and 10% level which indicated that using more of these inputs in Binadhan-14 production could increase the yield to some extent. Farmers' characteristics like age, farming experience and agricultural training found negatively related to their yield gap of the Binadhan-14. Absence of proper knowledge about the optimum input use and lack of institutional training as well as inadequate extension services were responsible for the reduced yield in most farmers’ fields. The government should realize that yield gap exists in rice crops of Bangladesh and, therefore, explore the scope to increase production as well as productivity of rice by narrowing the yield gap and thereby ensure food security.
Bangladesh J. Nuclear Agric, 38(2): 111-123, 2024
Protocol development of irradiated rice calli and subsequent in vitro regeneration
Authors: Islam M M , Sarker P , Nadim M K A , Khan T Z , Rahman M , Uddin M I
Published: February 2025

Fine and aromatic rice varieties, such as Kataribhog, hold significant commercial value in Bangladesh, particularly in regions like Dinajpur where Kataribhog is primarily cultivated. Despite its popularity, Kataribhog rice has a low yield (less than 2.50 t/ha) and is prone to lodging. To address these issues, a study was conducted using in vitro culture techniques combined with gamma irradiation (60Co) to improve the variety. Three different media (PT-100G, PT-011G, and PT-100) were used to induce callus, followed by exposure to varying radiation doses (10Gy, 12Gy, and 15Gy). The PT-100G medium found most effective, inducing an embryogenic callus formation rate of 32.93%, while PT-011G and PT-100 showed lower rates 27.87% and 11.11%, respectively. A radiation dose of 10Gy was found optimal, with an 80% survival rate for calli and the best plant regeneration outcomes.
Bangladesh J. Nuclear Agric, 38(2): 151-159, 2024
Mối liên kết giữa phát triển công nghiệp và tính bền vững môi trường: Bằng chứng từ các nước ASEAN
Authors: Đỗ Thị Hoa Liên
Published: February 2025

Nghiên cứu này nhằm đánh giá mối liên hệ giữa phát triển công nghiệp với tính bền vững môi trường ở các nước ASEAN bằng việc sử dụng dữ liệu bảng trong giai đoạn 1995-2022. Các kiểm định đồng tích hợp để xác định mối quan hệ cân bằng dài hạn giữa các biến, kỹ thuật hồi quy nhóm trung bình gộp (ARDL-PMG) và kiểm tra nhân quả để xác định các tác động dài hạn và ngắn hạn được thực hiện. Kết quả ước tính chính cho thấy tồn tại mối quan hệ dài hạn và các tác động tiêu cực và tích cực. Giá trị gia tăng công nghiệp (IVA) làm giảm tính bền vững môi trường (LCF) và giá trị gia tăng công nghiệp trên mỗi lao động (IPW) làm tăng LCF. Ngoài ra, kiểm định nhân quả cho thấy mối quan hệ hai chiều giữa LCF và các biến giải thích. Dựa trên những kết quả này, tác giả đưa ra các hàm ý chính sách.
WHAT IS PARENT EDUCATION? A Guide to Encouraging Appreciative Parenting
Authors: COJOCARU Stefan , COSTACHE Luminita , COJOCARU Daniela , APOPEI Simona , IONESCU Anda , PRICOPE Diana
Published: February 2025

This guide is designed for parents and professionals interested in developing parenting skills through appreciative methods. The introduction to parental education highlights the benefits of a positive approach in parent-child relationships, while the program description details the structure, topics covered, and format of Appreciative Parental Education (APE) courses. The program is organized into small groups conducted in a supportive environment, with sessions focused on processing, repetition, and experience sharing. The materials used and the well-trained staff contribute to the program's success, and chapters on parental educator training and APE principles underline its theoretical and practical foundations. Careful monitoring and evaluation of the program's effects showcase the positive impact of APE on family relationships and children's emotional development. The guide concludes with a bibliography that supports the program's scientific basis.
Assessment of gas exchange parameters of hyssop selection samples at the juvenile stage of ontogenesis under salt stress
Authors: Chernyavskih Vladimir , Dumacheva Elena , ShEIH Ubayd
Published: February 2025

The parameters of gas exchange at the juvenile stage of ontogenesis in individuals of selection samples of two morphotypes of hyssop under the influence of stress factors (salinity conditions and different light intensities) were studied. The study was conducted on cotyledon leaves of selection samples of white-flowered hyssop (Hyssopus officinalis f. albus) and blue-flowered hyssop (H. officinalis f. cyaneus) using the LI-6800, LI-COR system. Salinity conditions were simulated: control — water (H2O), experiment (0.05M NaCl). At the juvenile stage of ontogenesis, significant differences in the parameters of CO2 assimilation and transpiration intensity were established in breeding specimens of different morphotypes in terms of resistance to abiotic stress factors. The studied breeding specimens of both blue-flowered and white-flowered morphotypes showed a sufficiently high degree of resistance to salinity and will be used as sources of valuable breeding traits in further studies.
Effect of substances with non-biocidal activity on overcoming of herbicide stress at white lupin cultivation
Authors: Slesareva Tatyana
Published: February 2025

The article presents the tests’ results for the effect of substances with non-biocidal activity on overcoming of herbicide stress because of application of the herbicide Action at growing plants at white lupin cultivation. It’s revealed that the application of substances with non-biocidal activity Bioterra Antistress, Izagri Vita, Epin Extra resulted in the highest decrease of toxicity because of use of the herbicide Action at growing plants of white lupin. The significant true increase of seed yield made 0.31–0.38 t/ha compared to the variant with application of the herbicide Action.
Efficiency of application of macrofertilizers in cultivation of narrow-leaved lupine on sandy soils contaminated with radioactive cesium
Authors: Vorob'eva L. , Anischenko Valeriy , Adamko Vasily
Published: February 2025

This paper presents the results of the research obtained in a short-term field experiment conducted on light-textured soils exposed to radioactive contamination. The effectiveness of using potash fertilizers in different doses and types on the yield of green mass, the specific activity of radiocesium and the forage value of narrow-leaved lupine is analyzed. From the results obtained in the experimental conditions of our experiment it is evident that the variant with the dose of macrofertilizers — P45K150 is ideal for obtaining the highest yield of green mass. In the variant of the experiment using only P45, the highest accumulation of radioactive cesium is observed. It was found that in order to obtain green mass with the specific activity of cesium-137 below the permissible level, it is advisable to use macrofertilizers in doses not lower than P45K210. The highest collection of digestible protein in the yield of green mass of lupine was achieved with the use of the maximum dose of mineral fertilizers P45K210.
Cereal-legume grass mixtures and their role in soil fertility conservation
Authors: Chernyavskih Vladimir , PEChEGINA Yuliya , BIYuShKINA Anna , Dumacheva Elena , Grebennikov Artem , PEChEGIN Aleksandr , MAKSIMOVA Polina
Published: February 2025

A comprehensive study has been carried out to assess the productivity of perennial grasses when using soil-saving technologies in comparison with traditional tillage methods. The results of dispersion analysis showed that the value of the index of total above-ground underground and productivity of perennial grasses significantly depends on the species composition of the grass stand. It was found that the difference between the perennial fallow land and fields with perennial grasses at the use of soil-saving technologies did not exceed 13.9% in terms of total aboveground productivity. Accumulation of underground mass on the fallow plot and on plots with soil conservation technologies is approximately at the same level — 1.91 kg/m2 in the control and 1.85–2.25 (average 2.04) kg/m2 in soil conservation rotations. Alfalfa crops, providing greater aboveground productivity, are more intensive in terms of production, but less effective in increasing the organic matter content in soils compared to cereal-legume grass mixtures. In conservation agriculture it is necessary to use cereal-legume grass mixtures as more nature-like, and to increase intensification of agricultural production it is necessary to use alfalfa crops.
Breeding achievements of the Kaliningrad Research Institute of Agriculture – branch of the Federal Scientific Center “V. R. Williams Institute of Crops and Insemination
Authors: Zarudnyy Vladimir , Krasnoperov1 Andrey , BARDASh Veronika
Published: February 2025

In 2024, the Kaliningrad Research Institute of Agriculture – a branch of the Federal Scientific Center "VIK named after V. R. Williams" celebrates its 75th anniversary. This article summarizes the results of breeding and seed production work and discusses the prospects for further development of the research institution. Over the years, scientists have developed 30 varieties of 25 species of both traditional and non-traditional forage crops. In recent years, three new intensive-type varieties have been created and patented for the conditions of the Kaliningrad region: Festulolium Kaliningradsky VIK, hybrid clover Slavyansky, and winter barley Slad. The article examines methods for obtaining new varieties, as well as their main yield and morphobiological characteristics. The role of the Institute in the development of forage production and strengthening the resilience of the region's agro-industrial complex is highlighted.
Reed canary grass (Phalaroides arundinacea L.) is a rare species of forage plants. Options and prospects for use
Authors: Kostenko Sergey , Kostenko Natalia , Dumacheva Elena , USOL'CEVA Elena
Published: February 2025

Reed canary grass is a fairly homogeneous, monotypic species, widespread both on the Eurasian continent and in North America. In Russia, this species grows throughout the territory from the southern borders to the Arctic Circle. The optimal habitat for this species is always associated with increased and even excessive soil moisture. This quality determines the use of canary grass in forage production.
Morphobiological and biochemical peculiarities of phacelia pizhmolistnaya in phytocenoses of the Central Black Earth Region
Authors: Dumacheva Elena , Chernyavskih Vladimir , MAKSIMOVA Polina , GONChAROVA Natal'ya , Gorshkov Maksim , Kozlova Yana , ALTUHOV Daniil
Published: February 2025

Genetic resources of wild populations of promising fodder crop Phacelia pizhmolistnaya (Phacelia tanacetifolia Benth.) in different ecotopes of the Central Black Earth region have been studied in expeditionary research. The samples, which can serve as sources of valuable breeding traits: plant height; low pubescence of leaves and stems; content of dry matter, protein, fat, soluble carbohydrates, high yield of green mass and seeds, were selected. The collection of Phacelia pzhmolistnya was collected for further study and use in breeding work.
Comparison of Brassicaceae species by sowing qualities
Authors: AVEDISYaN Sergey
Published: February 2025

The data of comparing the seeds of Brassicaceae crops by sowing qualities obtained on the basis of the Federal Williams Research Center of Forage Production and Agroecology are presented. It has been established that all varieties of the studied cruciferous crops have good indicators of germination and growth strength. Samples of varieties of white mustard Aphrodite, oilseed radish Snezhana, spring mustard Nadezhda are superior in germination and growth strength to spring rapeseed varieties and their use implies more friendly and stable inputs. It is also worth noting that the Nadezhda sample, despite showing the lowest mass of 1000 seeds, had the highest percentage of germination, as well as high growth rates. Thus, it is impossible to directly link the weight of the seed and the indicators of germination and growth strength.
Numerical analysis of time-dependent behavior of an embankment on PVD-installed Sebou soft soils
Authors: Mridakh A. H. , Nguyen B. P. , Ejjaaouani H. , Labied H.
Published: February 2025

In this paper, finite element (FE) modeling is conducted for a high-speed railway embankment on soft soils in Sebou, Morocco. Discrepancies arise between predicted and measured behaviors when using standard creep models. To address this, an advanced anisotropic creep constitutive model, known as Creep-SCLAY1S, is applied for comparison, focusing on the prefabricated vertical drain (PVD) treated soft soils. This advanced model incorporates fabric anisotropy, soil structure, and time-dependent behavior. The time-dependent soft soil creep model (SSCM) is also employed for further comparison. Numerical predictions are then compared with field instrumentation data. Results indicate that Creep-SCLAY1S offers improved predictions of in situ measurements, particularly post-construction, and provides a more accurate peak excess pore pressure during the embankment’s rapid surcharge phase.
Gut microbiota-derived imidazole propionate: an emerging target for the prevention and treatment of cardiometabolic diseases
Authors: Zeng Yan , Wu Qi , Guo Man , Teng Fangyuan , Jiang Chunxia , Chen Jiao , Tan Xiaozhen , Zeng Chen , Long Yang , Law Betty Yuen-Kwan , Xu Yong
Published: February 2025

Despite significant advancements in prevention and treatment, cardiometabolic diseases continue to pose a high burden of incidence and mortality. The chronic progression of these diseases necessitates the identification of early and complementary therapeutic targets to elucidate and mitigate residual risks in patient care. The gut microbiota acts as a sentinel between internal and external environments, transmitting modified risks associated with these factors to the host. Imidazole propionate (ImP), a histidine metabolite originating from the gut microbiota, gained attention after being found to impair glucose tolerance and insulin signaling several years ago. Epidemiological studies over the past five years have demonstrated a robust correlation between ImP and an increased risk of onset of type 2 diabetes (T2D) and obesity, exacerbation of kidney traits in chronic kidney disease (CKD), progression of atherosclerotic plaques, and elevated mortality rates in heart failure (HF). These findings suggest that ImP may serve as a pivotal target for the prevention and treatment of cardiometabolic diseases. Mechanistic insights have uncovered associations between ImP and insulin resistance, impaired glucose metabolism, chronic inflammation, and intestinal barrier damage. This review provides a comprehensive summary of the current evidence regarding the association between ImP and cardiometabolic impairment, highlighting its potential in advancing personalized approaches to disease prevention and management, and exploring the intricate interplay of diet, gut microbiota, and ImP in cardiovascular metabolic impairment. Overall, this review offers valuable insights into the multifaceted roles of ImP in cardiometabolic diseases, identifies current knowledge gaps, and discusses future research directions.
A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis
Authors: Yu Xiaoqing , Deng Qin , Gao Xin , He Lingyun , Hu Daixing , Yang Lu
Published: February 2025

Background

Despite having negative lymph node (N0) status, thyroid cancer (TC) patients can still experience distant metastasis (DM), which significantly impacts their survival. This study aimed to investigate the prognostic factors for DM in TC patients (N0) and develop a predictive nomogram model for analyzing the prognosis of TC N0 patients with DM.

Methods

Data collected from the Surveillance, Epidemiology, and End Results (SEER) database for 18,504 TC patients (N0) between 2004 and 2015 were analyzed. Univariate and multivariate analyses were used to identify independent prognostic factors for DM in TC N0. These independent factors were used to build a nomogram model to predict overall survival (OS) at 1, 3, and 5 years for TC patients (N0) with DM.

Results and conclusion

This study examined the clinicopathological features associated with the risk and prognosis of DM in TC patients (N0), and successfully established and validated a nomogram capable of predicting OS in individual patients with DM. The nomogram is highly useful for the timely identification of TC patients (N0) at high risk of DM by physicians, enabling individualized survival evaluations and treatment for TC patients with DM (N0).
Sexual dimorphism in immunity and longevity among the oldest old
Authors: Arakelyan Nelli A. , Kupriyanova Daria A. , Vasilevska Jelena , Rogaev Evgeny I.
Published: February 2025

Human longevity is a sex-biased process in which sex chromosomes and sex-specific immunity may play a crucial role in the health and lifespan disparities between men and women. Generally, women have a higher life expectancy than men, exhibiting lower infection rates for a broad range of pathogens, which results in a higher prevalence of female centenarians compared to males. Investigation of the immunological changes that occur during the process of healthy aging, while taking into account the differences between sexes, can significantly enhance our understanding of the mechanisms that underlie longevity. In this review, we aim to summarize the current knowledge on sexual dimorphism in the human immune system and gut microbiome during aging, with a particular focus on centenarians, based exclusively on human data.
Biobanking marine biodiversity in the Arctic
Authors: Chernikhova Darya , Basran Charla J.
Published: February 2025

Biorepositories, or biobanks, are vital to marine science. Their collections safeguard biological knowledge, enable follow-up studies and reproducibility confirmations, and help extend ecological baselines. Biorepository networks and data portals aggregate catalogs and facilitate open data and material exchange. Such integrations enrich contextual data and support holistic ecosystem-based research and management. In the Arctic, where researchers face vast scales, rapidly changing ecosystems, and limited resampling opportunities, biobanking builds capacities. However, marine and polar biodiversity remains underrepresented in collections. Heterogeneous methodologies and documentation practices hinder data integrations. And open science faces high institutional and cultural barriers. Here, we explore the potential of biobanking to amplify the impact of individual marine studies. We address gaps in standardization and vouchering and suggest improvements to funding and publishing models to incentivize collaboration. We bring together calls for biobanking advancements from diverse perspectives and provide examples of expeditions, databases, specimen collections, and standards. The general analysis is illustrated with two case studies, showcasing the range of the field: inclusion of citizen science observations in cetacean monitoring, and preservation of specimens in environmental microbiome studies. In the former, we suggest strategies for harmonizing data collection for inclusion in global databases. In the latter, we propose cooperative field collection and intact living microbiome (complex microbial community) cryopreservation. Our perspective frames biobanking as a cooperative research strategy, essential to accelerating science under the current climate change-related pressures. We advocate for international investment as the precautionary approach to academic and conservation stewardship of the Arctic biodiversity heritage.
Dietary Lycium barbarum polysaccharide modulates growth performance, antioxidant capacity, and glucolipid metabolism in largemouth bass (Micropterus salmoides) fed with high- carbohydrate diet
Authors: Qi Long , He Yuyun , Zhong Guofang
Published: February 2025

To investigate the ameliorative effects of Lycium barbarum polysaccharide (LBP) on growth performance, oxidative stress, and glucolipid metabolism in largemouth bass (Micropterus salmoides) fed with high-carbohydrate diets. Fish (41.81 ± 0.36) g were fed on high-carbohydrate diets (15% α-starch) supplemented with 0% (15% α-Starch and no LBP, HLBP), 0.2g/kg LBP (LBP0.2), 0.4g/kg LBP (LBP0.4), 0.6g/kg LBP (LBP0.6) and 0.8g/kg LBP (LBP0.8) for 56 days. An additional low-carbohydrate (10% α-starch) dietary group (10% α-Starch and no LBP, NLBP) was set up and fed for the same 56 days. The final body weight (FBW), weight gain ratio (WGR), and specific growth rate (SGR) of fish in the LBP0.6 group were the highest, and the treatment groups were all significantly higher than in the HLBP group (P < 0.05). The activities of AMS, LPS, and TPS in the intestine and liver were all highest in the LBP0.6 group and significantly higher than in the HLBP group (P < 0.05). In the intestine and liver, the activities of T-AOC, CAT, GSH-PX, and SOD were significantly higher in the LBP0.6 and LBP0.8 groups than in the HLBP group (P < 0.05). The expression of CAT, SOD, and GPX genes were highest in the LBP0.8 group and significantly higher than in the HLBP group (P < 0.05). In the intestine and liver, the expression of IL-1β, IL-8, and TNF-α genes were significantly lower in the LBP0.4, LBP0.6, and LBP0.8 groups than in the HLBP group (P < 0.05); the expression of IL-10 and TGF-β1 genes were significantly higher in the LBP0.6 and LBP0.8 groups than in the HLBP group (P < 0.05). The expression of GK, PFK, and G6P genes were significantly higher in the LBP0.6 and LBP0.8 groups than in the HLBP group (P < 0.05). The expression of ACC, CPT-1, and FAS genes were significantly higher in the LBP0.4, LBP0.6, and LBP0.8 groups than in the HLBP group (P < 0.05). In summary, the addition of 0.6 g/kg LBP was effective in ameliorating the negative effects of a high-carbohydrate diet on largemouth bass.
Case report: Efficacy of tofacitinib in the treatment of generalized pustular psoriasis
Authors: Wang Xian , Zhang Mei , He Ming , Tang Ting
Published: February 2025

Generalized pustular psoriasis (GPP) is a rare and potentially life-threatening autoimmune inflammatory skin disease. Tofacitinib is a non-selective, first-generation Janus kinase (JAK) inhibitor. Currently, both domestic and international reports regarding the use of tofacitinib mainly have primarily focused on the treatment of psoriasis vulgaris and psoriatic arthritis. As GPP is a rare skin disease, reports on the use of tofacitinib in the treatment of GPP are rare. This report presents a case of severe GPP that was effectively treated with tofacitinib. This case suggests that this non-selective JAK inhibitor, which has strong anti-inflammatory effects, could serve as an effective treatment option for cases of acute exacerbation of GPP, with a good safety profile.
Yersiniabactin produced by Escherichia coli promotes intestinal inflammation through lipid peroxidation and ferroptosis
Authors: Wang Hao , Chen Bingxun , Xiao Peng , Han Dongmei , Gao Bin , Yan Yulin , Zhao Ru , Pan Tianling , Zhang Jingsong , Zhou Meng , Lv Longbao , Gao Hong
Published: February 2025

Escherichia coli (E. coli), a major foodborne pathogen, poses significant risks to public health by causing gastrointestinal diseases. Among its virulence factors, Yersiniabactin (Ybt), a siderophore, plays a crucial role in iron acquisition and enhancing intestinal colonization. Despite previous studies highlighting E. coli-Ybt’s involvement in inflammation, its exact mechanisms remain unclear. This study investigates how Ybt contributes to intestinal inflammation through ferroptosis, using both in vitro and in vivo models. Our findings demonstrate that Ybt promotes oxidative stress, lipid peroxidation, inflammation, and iron accumulation in intestinal epithelial cells, leading to ferroptosis. Mechanistically, Ybt suppresses the Keap1/Nrf2 pathway, amplifying reactive oxygen species (ROS) and activating the TNF/NF-κB pathway, which drives inflammation. Moreover, Ybt induces lipid peroxidation via the arachidonic acid pathway, producing 6-trans-leukotriene B4 (6-transLTB4), which exacerbates inflammation and ferroptosis. Exogenous 6-transLTB4 further intensifies this cascade. Additionally, Ybt disrupts iron efflux by suppressing FPN1 expression, causing excessive intracellular iron accumulation. Using tree shrews as an in vivo model, we confirm that Ybt-induced ferroptosis significantly aggravates intestinal inflammation. These findings underscore the pathogenic role of Ybt in E. coli-induced intestinal injury and highlight ferroptosis as a novel mechanism contributing to gut health disruption. This study provides new insights into the molecular pathways of E. coli infection, with implications for therapeutic strategies targeting ferroptosis in intestinal diseases.
Critical vitamin D and iron intakes in infants aged 6–11 months: results from the nationwide German KiESEL study
Authors: Burgard Leonie , Spiegler Clarissa , Jansen Sara , Brettschneider Anna-Kristin , Straßburg Andrea , Alexy Ute , Storcksdieck genannt Bonsmann Stefan , Ensenauer Regina , Heuer Thorsten
Published: February 2025

Background

Nutrient intake during the phase of complementary feeding is pivotal for healthy development, yet current data for European infants are lacking.

Objective

To provide latest data on energy and nutrient intake of infants in Germany, to compare these with the Dietary Reference Values (DRVs) of the European Food Safety Authority, and to assess the contribution of vitamin D supplementation and commercial infant foods to nutrient intake.

Design

Analyses are based on weighed food records (3 + 1 day) of 118 infants aged 6–11 months from the representative cross-sectional Children’s Nutrition Survey to Record Food Consumption (KiESEL) conducted in Germany from 2014 to 2017. Energy and nutrient intake was calculated using the German Nutrient Database BLS 3.02, the LEBTAB database, and a supplement database.

Results

Median energy and protein intakes were above DRVs, while fat intake was below. Dietary vitamin and mineral intakes mostly met or exceeded the DRVs. However, iron intake reached neither the Population Reference Intake nor the Average Requirement. Vitamin D intake from foods was below half the Adequate Intake (AI). When additionally considering vitamin D supplements, administered to 51.7% of infants, the AI was reached. Girls’ iodine intake was below the DRVs. In contrast, the intakes found for retinol equivalents, vitamin K, and vitamin C were about four times the DRVs. Commercial infant foods were key dietary sources for all nutrients for which intakes deviated considerably from DRVs.

Conclusion

Micronutrient intake, particularly of iron and vitamin D, needs improving in infants aged 6–11 months in Germany. Vitamin D supplementation was a prerequisite for meeting the AI, confirming the necessity for vitamin D supplements in infancy and the promotion of the respective recommendations. The considerable up- and downward deviations from DRVs point to a need for adjusting fortification levels of commercial infant foods in European legislation.
Association of dietary intake of saturated fatty acids with obstructive sleep apnea: mediating effects of Life’s Crucial 9
Authors: Gou Ruoyu , Chen Lili , Cheng Zeyi , Cun Jiawei , Li Guanghua
Published: February 2025

Introduction

Obstructive sleep apnea (OSA) is a global public health issue. Life’s Crucial 9 (LC9) is recognized as a powerful tool for assessing cardiovascular health. Although the etiology of OSA remains unclear, saturated fatty acids (SFAs) and cardiovascular health are increasingly regarded as a non-negligible element. This study aims to assess the association between dietary intake of SFAs and the risk of OSA, and the mediating effect of LC9.

Methods

Based on the National Health and Nutrition Examination Survey (NHANES), dietary questionnaires of participant were collected, and the average values of 24-h dietary recall data over 2 days were obtained. A continuous cross-sectional analysis with dietary energy adjustment was employed. Weighted multivariable logistic regression models were used to estimate the weighted odds ratios (ORs) and their 95% confidence intervals (CIs) for SFAs and OSA. Evaluate the mediating role of LC9 in the relationship between SFAs and OSA.

Results

A total of 13,563 participants aged 20 years and above were included in this study. The intakes of Sfa 4.0 and LC9 among participants with OSA were significantly lower than those in the normal population. After adjusting for confounding factors, total SFAs could increase the risk of OSA [Model 1, Q3, 0.03, 1.49 (1.03, 2.15); Model 2, Q3, 0.04, 1.47 (1.01, 2.13)]. It was emphasized that dietary intake of Sfa 12.0, Sfa 14.0, and Sfa 16.0 were protective factors for OSA, especially among participants aged 45–64 years and white individuals. Moreover, Sfa 12.0 exhibited a better protective effect in female participants [Q3, 0.04, 0.66 (0.45, 0.99)]. In addition, the cardiovascular health score - LC9 had a mediating effect in Sfa4.0 on OSA [Proportion of mediation: −0.035, 95% CI: (−0.058, −0.01); p= 0.002]. There was a nonlinear relationship between dietary intake of Sfa 12.0, Sfa 16.0, and Sfa 18.0 and OSA (P-Nonlinear = 0.013).

Discussion

These findings suggest that dietary mixtures of saturated fatty acids increase the risk of OSA. Among them, SFA 4:0 can increase the risk of OSA through the level of cardiovascular health. However, contrary to traditional beliefs, long-chain saturated fatty acids can reduce the risk of OSA.
circDENND4C serves as a sponge for miR-200b to drive non-small cell lung cancer advancement by regulating MMP-9 expression
Authors: Lv Yaming , Wang Lan , Zhang Yunhui , Wei Dong , Hu Yajie
Published: February 2025

Introduction

Lung cancer has a higher incidence and mortality rate than other cancers, especially non-small cell lung cancer (NSCLC), accounting for 85% of the cases. The role of the circDENND4C/miR-200b/matrix metalloproteinase-9 (MMP-9) regulatory axis in NSCLC remains largely unknown.

Methods

NSCLC cell lines were used to examine the expression of circDENND4C, miR-200b, and MMP-9 via qRT-PCR or Western blot. The target relationship of circDENND4C, miR-200b, and MMP-9 was examined by RNA fluorescence in situ hybridization (RNA-FISH), immunofluorescence (IF), dual-luciferase reporter system, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot. Then, a cell count kit-8 (CCK-8) experiment, flow cytometry, and migration/invasion assays were performed to assess the biological function of circDENND4C, miR-200b, and MMP-9 by transfecting with their overexpression or knockout plasmids in A549 cells. Finally, the proteins related to cell adhesion and tight junction were further tested by Western blot and IF.

Results

circDENND4C and MMP-9 were found to be highly expressed in NSCLC cell lines, while miR-200b was lowly expressed in NSCLC cell lines. Moreover, circDENND4C could sponge miR-200b to target MMP-9. Subsequently, it was observed that knockdown of circDENND4C and MMP-9 or the upregulation of miR-200b repressed cell proliferation and cell cycle progression, increased cell apoptosis, and hindered cell migration and invasion. Finally, it was also found that the circDENND4C/miR-200b/MMP-9 regulatory axis might be involved with cell adhesion and tight junction to influence tumor metastasis.

Conclusions

Altogether, our study reveals a novel regulatory loop in which the circDENND4C/miR-200b/MMP-9 axis may modulate NSCLC progression, indicating potential biomarkers for the diagnosis or treatment of NSCLC.