bluuebunny/crossref_metadata_2025 huggingface dataset:
OPTIMALISASI BAKAT DAN POTENSI KEBAIKAN DALAM PERSPEKTIF AL-QUR'AN: ANALISIS QS. AN-NAHL AYAT 78, QS. AS-SYAMS AYAT 8-10, DAN QS. AL-ISRA AYAT 32
Authors: Rozaq Muhammad , Fahmi Tubagus , Nur Rohmah Isnaini , Rahmawati Ana
Published: December 2024

This article presents a comparative analysis of honing different talents and potential for goodness, specifically comparing various methods or approaches to developing and maximizing an individual's talents and potential for goodness. The research method used is library research. The findings indicate that humans have the potential for both good and bad tendencies. The moral teachings in the Quran emphasize the development of good traits and the avoidance of bad ones, as explained in Ibn Kathir's commentary on the purity and corruption of a person’s inner self. Humans possess two tendencies that differentiate between good and bad. Allah provides imbalance and punishment in accordance with human choices. Acts of adultery and murder are described in the Quran as grave wrongdoings that must be avoided and controlled by humans to prevent their negative consequences.
 
Keywords: Talent, potential, character
 
Artikel ini menyajikan perbandingan analisis tentang mengasah bakat dan potensi kebaikan yang berbeda, yaitu menyajikan suatu perbandingan yang menganalisis cara atau metode yang berbeda dalam mengembangkan atau memaksimalkan bakat serta potensi kebaikan seseorang. Metode penelitian yang diterapkan adalah studi kepustakaan (library research). Hasil penelitian ini adalah Manusia mempunyai kemungkinan serta kecenderungan baik dan buruk. Pelajaran moral dalam Al-Quran fokus pada pertumbuhan sifat baik dan menjauhi sifat buruk, seperti yang dijelaskan dalam penjelasan Ibnu Kasir tentang kesucian dan kekotoran batin seseorang. Manusia mempunyai dua kecenderungan yang dapat membedakan antara yang baik dan yang buruk. Allah memberikan ketidakseimbangan dan hukuman sesuai dengan keputusan manusia. Perbuatan zina dan pembunuhan dijelaskan dalam Al-Quran sebagai perilaku yang sangat buruk yang harus dijauhi dan dikendalikan manusia demi menghindari konsekuensi negatifnya.
 
Kata kunci: Bakat, potensi, karakter
Los Elementos Socioculturales en la Enseñanza del Inglés con Fines Médicos
Authors: Naranjo Corría Rebeca , Santiesteban Naranjo Ernan , Ramírez Lozada Haydée , Suárez Lezcano José
Published: December 2024

Esta investigación parte de la necesidad de propiciar el desarrollo de elementos socioculturales a partir del proceso de enseñanza aprendizaje en idioma inglés con fines médicos en estudiantes de cuarto año de Medicina, en la Universidad de Ciencias Médicas de las Tunas, Cuba. En el proceso de investigación se utilizaron métodos de nivel empírico y teórico -- histórico-lógico, triangulación de la información, análisis y síntesis, hipotético-deductivo, la entrevista, la prueba pedagógica, y el enfoque sistémico- estructural. La aplicación de los referidos métodos posibilitó la elaboración de una estrategia didáctica dinámico-participativa para la enseñanza de los elementos socioculturales de los pueblos de habla inglesa, desde el inglés con fines específicos. La estrategia otorga el papel protagónico al estudiante, el que a partir de un esquema de contenido y de forma, exterioriza en contextos reales la apropiación de los elementos socioculturales de dichos pueblos. La aplicación de esta propuesta posibilitó el desplazamiento de la Zona de Desarrollo Próximo de los estudiantes, al motivarlos para el aprendizaje de la lengua y su cultura; eventualmente se evidenció en la transformación de rasgos negativos de su comportamiento.Palabras clave: elementos socioculturales; inglés con fines médicos; enseñanza.  AbstractThis research departs from the need to promote the development of cultural elements from the very process of learning the English Language for medical purposes in fourth year medical students, in the University of Medical Sciences of Las Tunas, Cuba. In the research process we used empirical and theoretical methods —historical- logical, triangulation of information, analysis and synthesis, hypothetical-deductive, the interview, the educational testing, and the systemic-structural approach. The application of the aforementioned methods made possible the development of a dynamic-participatory teaching strategy to teach the sociocultural elements of the English-speaking peoples from the English for specific purposes. The strategy gives the student a starring role, who from a scheme of content and form, externalizes in real contexts the appropriation of the socio-cultural elements of these peoples. The implementation of this proposal made the displacement of the students´ Zones of Proximal Development possible, by motivating them to learn the language and culture; the transformation of negative traits of their behavior was eventually evidenced.Keywords: sociocultural elements; English for Medical Purposes; teaching.
El Aprendizaje Cooperativo en los Estudiantes de Diseño Gráfico de la Pontificia Universidad Católica del Ecuador, Sede Esmeraldas
Authors: Vásquez Coisme Ladys
Published: December 2024

Para identificar las formas de aplicación del aprendizaje cooperativo en los estudiantes de diseño gráfico, se realizó un estudio longitudinal retrospectivo, cuasi-experimental, cuanti-cualitativo y analítico en la Escuela de Diseño Gráfico de la Pontifica Universidad Católica del Ecuador, Sede Esmeraldas (PUCESE), en el período comprendido en mayo de 2014 y febrero de 2015. La población la conformaron 65 estudiantes, matriculados en 2, 3, 5, 6 y 7 semestres y seis docentes de la especialidad. Para la recolección de los datos se utilizaron el cuestionario y la ficha de observación. Los resultados obtenidos demostraron que los docentes confunden el trabajo en equipo con aprendizaje cooperativo y se enfocan en enseñar un contenido, pero no en desarrollar alguna competencia. El 40% de los estudiantes tiene una actitud desinteresada. Se diseñó un instructivo llamado Cooperando Aprendo Más y Desarrollo Competencias para aplicar el aprendizaje cooperativo de forma correcta, el que se utilizó en un grupo de 12 estudiantes y que demostró la aplicación del aprendizaje cooperativo y el desarrollo de la competencia disciplinar del contenido establecido en esa clase.Palabras clave: aprendizaje cooperativo; competencia; diseño gráfico AbstractA retrospective, quasi-experimental, quantitative-qualitative and analytical study was carried out at the School of Graphic Design of the Pontifical Catholic University of Ecuador, Esmeraldas Campus (PUCESE) to identify cooperative learning applications in Graphic Design students. The study was done in the period between May 2014 and February 2015. The population was made up of 65 students, enrolled in 2, 3, 5, 6 and 7 semesters and six teachers of the specialty. For the collection of the data, a questionnaire and an observation sheet were used. The results showed that teachers confuse teamwork with cooperative learning and focus on teaching content, but not on developing any competences. 40% of the students have a disinterested attitude. An instruction called Cooperating I Learn More and Develop Competences was designed to apply cooperative learning correctly, which was used in a group of 12 students and which demonstrated the application of cooperative learning and the development of the disciplinary competence of the content established in that class.Keywords: Cooperative learning; competence; graphic design
Perancangan Virtual Private Network Dengan Metode PPTP Menggunakan Mikrotik
Authors: Arfind Reza , Supendar Hendra , Fahlapi Riza
Published: December 2024

Perkembangan usaha tekstil sudah semakin meluas, sehingga dalam menopang efektifitas dalam pelaksanaannya membutuhkan koneksi agar saling terhubung antar satu tempat dengan cabang perusahaan lainnya, namun dalam pelaksanaannya perusahaan perlu adanya jaringan yang lebih cepat dan aman untuk saling bertukar data, untuk terciptanya jaringan yang cepat dan aman maka diusulan perancangan Virtual Private Network (VPN) dengan Metode Point to Point Tunnel Protocol (PPTP) menggunakan Mikrotik. Adapun alat yang digunakan yaitu Mikrotik CHR. Dalam pengaplikasiannya Mikrotik CHR akan di jadikan server yang menghubungkan antara kantor pusat dengan cabang dimana Mikrotik yang ada di kantor pusat dan kantor cabang akan terhubung dengan IP address yang di distribusikan oleh Mikrotik CHR sehingga jaringan tersebut akan terhubung seperti jaringan lokal. Hasil akhir dari konfigurasi ini, terbentuknya jaringan VPN menggunakan metode PPTP pengujian akhir ditutup dengan di lakukannya uji coba PING dari komputer client ke Mikrotik CHR menghasilkan kecepatan sangat stabil yang terlihat dari waktu respon server dengan komputer.
 
The development of the textile business has become increasingly widespread, so that in supporting effectiveness in its implementation it requires connections so that they are connected to each other between one place and other company branches, but in practice the company needs a faster and safer network to exchange data, to create a fast and secure network then it is proposed to design a Virtual Private Network (VPN) with the Point to Point Tunnel Protocol (PPTP) method using Mikrotik. The tool used is Mikrotik CHR. In its application, Mikrotik CHR will be used as a server that connects the central office with branches where the Mikrotik at the head office and branch offices will be connected to the IP addresses distributed by Mikrotik CHR so that the network will be connected like a local network. The end result of this configuration, the formation of a VPN network using the PPTP method, the final test was closed by carrying out a PING test from the client computer to Mikrotik CHR resulting in a very stable speed as seen from the server's response time with the computer.
Eficácia e segurança de abordagens farmacológicas no tratamento da obesidade: uma análise comparativa entre estratégias terapêuticas
Authors: Silva Caio Marques da , Santos Tiago Alves Bernardes dos , Bezerra Marjory Sandra de Lima , Júnior José Nilson de Lira Freire , Dantas Joás Paiva , Rodrigues Thiago Grande , Salazar Victor Alfonso Martinez , Rocha Ana Ruth Maia , Araujo Roberta Cristina Oliveira Duarte de , Dantas Giliane de Oliveira , Junior Jordão Luiz Moratelli , Lima Rodrigo Carneiro , Moura Gabriel Passos , Melo Maria Eduarda Passos de Araújo Leão
Published: December 2024

A obesidade é uma condição de saúde multifatorial associada a um aumento no risco de doenças crônicas, como diabetes tipo 2, hipertensão arterial e doenças cardiovasculares. Este estudo revisou abordagens farmacológicas disponíveis no Brasil para o manejo da obesidade, analisando medicamentos aprovados para pacientes adultos e suas respectivas eficácias, mecanismos de ação e perfis de segurança. Por meio de uma revisão narrativa da literatura, foram avaliados artigos publicados em bases de dados como PubMed, SciELO e Cochrane Library, com critérios rigorosos de inclusão e exclusão. Os medicamentos analisados incluem o orlistate, sibutramina, agonistas do receptor GLP-1 (liraglutida e semaglutida), a combinação de bupropiona com naltrexona e a lisdexanfetamina. O orlistate demonstrou efetividade ao reduzir a absorção de gorduras, enquanto a sibutramina apresentou benefícios no aumento da saciedade e na redução do consumo calórico, com restrições ao seu uso em pacientes com condições cardiovasculares. Os agonistas do receptor GLP-1 promoveram perdas de peso expressivas e melhora metabólica, com destaque para a semaglutida, que superou a liraglutida em estudos comparativos. A combinação de bupropiona e naltrexona foi eficaz na redução do apetite e na perda de peso quando aliada a mudanças comportamentais, enquanto a lisdexanfetamina mostrou resultados positivos no controle do transtorno de compulsão alimentar. Os achados deste estudo reforçam que a escolha do tratamento deve ser baseada no perfil clínico do paciente, associando farmacoterapia a intervenções no estilo de vida para alcançar melhores desfechos. A análise contribui para um entendimento mais aprofundado das opções terapêuticas disponíveis, auxiliando profissionais de saúde na tomada de decisões fundamentadas para o manejo da obesidade e suas comorbidades.
High Performers Need Feedback, Too: A Research-Backed Approach to Leveraging Feedback for Exceptional Talent
Authors: Westover Jonathan
Published: December 2024

High-performing employees are often overlooked when it comes to providing regular, constructive feedback. However, research shows that feedback is crucial for driving the performance of top talent. This article explores the science behind the importance of feedback for high performers, who have a deep hunger for growth, development, and continuous improvement. Drawing on key theories and empirical studies, the article outlines four practical strategies for leveraging feedback to unlock the full potential of exceptional employees: 1) establishing regular feedback touchpoints, 2) tailoring feedback to individual needs, 3) emphasizing actionable feedback, and 4) fostering a culture of feedback. By implementing these research-backed approaches, organizations can retain their top talent, drive exceptional performance, and position themselves for long-term success. The brief concludes by underscoring the importance of a tailored, collaborative feedback process that recognizes the unique motivations of high performers.
Ethical Dilemmas and challenges in research on orphans of Jammu and Kashmir: A study
Authors:   Maulana Azad National Urdu University, Butt Sarmad Yaseen
Published: December 2024

Orphanages play a very important part in providing care, assistance and support to orphans as well as to those children who are in need of childcare institutions. As far as the region of Jammu and Kashmir is concerned, orphanages are playing a climacteric role for the wellbeing and development of orphans. They provide these children lot of facilities including food, shelter and most important education and a feeling of stability. Despite their significance, conducting research on the status, condition, education of orphans residing in orphanages often poses significant challenges. This study examines the ethical challenges faced by researcher working on orphans residing in orphanages of Jammu and Kashmir. Based on the experiences of fieldwork, this paper culminates noteworthy and serious issues like bureaucratic impediments, privacy and confidentiality issues, emotional sensitivity of children and the ramifications of system deficiencies on research. This paper focuses on the problems and difficulties faced by researcher in the field. The objective of this paper is to identify and study the challenges faced by researcher while working on orphans residing in orphanages and to study bureaucratic and systematic barriers faced by researcher. The researcher has attempted to provide some recommendations with regard to problems and challenges.
Psilocybin Microdosing for Anxiety Relief in Young Adults: A Comparative Review of Emerging Evidence
Authors:   GCU, Lahore, Pakistan, Shabir Kanwal
Published: December 2024

Background

Anxiety disorders are increasingly prevalent among young adults. Traditional treatment options often fall short, and many patients live with treatment-resistant anxiety. Psilocybin is a psychedelic compound that has gained attention for its therapeutic potential against anxiety when used in microdoses.

Objective

This review aims to evaluate the emerging evidence on psilocybin microdosing as a potential intervention for anxiety relief in young adults. It examines psilocybin microdosing efficacy, safety, and underlying mechanism of action.

Methods

A systematic search was conducted across three major databases: PubMed, PsycINFO, and CINAH. Keywords were selected related to psilocybin microdosing and anxiety in young adults. Inclusion criteria focused on peer-reviewed studies published in English from 2014 to 2024, encompassing human participants aged 18–35 years. Data were synthesised narratively with thematic analysis of anxiety-related outcomes across studies. Tabular comparisons to highlight psilocybin microdosing’s relative efficacy, limitations, and methodological variations were used.

Findings

The findings suggest that psilocybin microdosing is associated with improved mood and reduced anxiety symptoms. It also enhances emotional resilience and mental well-being. Microdosing can modulate serotonin receptors, promote neural plasticity, and improve connectivity in certain brain regions implicated in emotional regulation. Short-term benefits include increased focus and cognitive flexibility, while long-term effects may involve sustained reductions in anxiety and improved overall mental well-being.

Conclusion

Psilocybin microdosing presents a promising alternative for managing anxiety in young adults for those who are resistant to traditional therapies. However, the variability in study designs and dosing regimens highlights the need for further research to establish standardised protocols and assess long-term safety and efficacy.
ATUAÇÃO DO CONSELHO ESCOLAR NA GESTÃO DEMOCRÁTICA DA EMEF PROFª LUCIANA PEDRONI, CAIEIRAS/SP.
Authors: Ricardo de Lima Sérgio , do Nascimento de Freitas Clariane
Published: December 2024

O presente trabalho aborda a percepção da comunidade escolar acerca da gestão
democrática e a atuação do Conselho Escolar da escola pública municipal, localizada em
Caieiras, São Paulo. A partir dos questionamentos: Qual a percepção da comunidade escolar a
respeito da gestão democrática? Como deve atuar o conselho escolar na perspectiva da
comunidade escolar? Esta pesquisa teve como objetivo geral investigar a efetivação da gestão
democrática através do conselho escolar de uma escola pública. Para tanto, os objetivos
específicos foram assim definidos: verificar a percepção sobre gestão democrática pela
comunidade escolar; conhecer a atuação do Conselho Escolar na gestão escolar; verificar o
conhecimento da comunidade escolar a respeito da convocação do Conselho Escolar e
identificar a forma de participação da comunidade escolar. Este estudo assumiu um caráter
qualitativo em relação ao levantamento e trato dos dados. A coleta de dados ocorreu através de
entrevistas e questionários, com questões fechadas, propostas aos grupos da comunidade
escolar. Os dados foram analisados qualitativamente através do procedimento de análise de
conteúdo. Acredita-se que este estudo contribui como fomento para o desenvolvimento de
ações e práticas visando ampliar a participação da comunidade escolar em colegiados e
processos de tomada de decisões, podendo auxiliar no delineamento de estratégias que
tornem relevante o papel do Conselho Escolar, bem como criar condições para participação e
inclusão de pautas pela comunidade escolar.
Unforgetting as a choreographic practice
Authors: Styve Holte Solveig
Published: December 2024

Unforgetting as choreographic practice questions how artistic research can contribute to the remembering of dance histories and a re-contextualisation through performance. Opening the creation process of the performance Frå Form til Famling (2023), Holte shares experiences from the encounter with these dance historical archives, transforming a document into an artistic experience to create a space for a polyphonic remembering, an unforgetting that expands the initial narrative, and that creates a space for remembering several histories at once.
Differences in Social Science Reporting
Authors: Korte Jasper
Published: December 2024

Public debate heavily relies on social scientific expertise as demonstrated by recent global events like the coronavirus pandemic. Social scientific knowledge is disseminated and discussed in the mass media, the main arena for the public understanding of social science. However, science communication research overlooks the significance of disciplinary differences in social science reporting while focusing on comparison with the natural sciences. To investigate the reporting of social sciences in the German press as societal communication, anthropology, sociology, and economics are compared within a distant reading approach. In the systematic sample (8,660 articles) over the previous 20 years, the absolute numbers for all disciplines are stagnant, but the share of reporting increases. The section distributions of the three disciplines are quite different but stable over time. In contrast, the sampled periodicals show only subtle differences in reporting. Dramatic events lead to a short-term increase in economics reporting. The combination of the metadata with the semantic structures of the text shows three distinct profiles of social science reporting. These findings reveal the varieties of social science reporting as an important feature in the societal role of the social sciences.
Sooryamoorthy: Sociology Global
Authors: Crothers Charles
Published: December 2024

Review of Sooryamoorthy, R. (2022) Sociology Global: Historical and Contemporary Perspectives.
Czy prawo konkurencji rozwiąże problem vendor lock-in w sektorze oprogramowania B2B?
Authors: Semeniuk Piotr
Published: December 2024

Prawo konkurencji zaczyna być wykorzystywane (na razie głównie w Stanach Zjednoczonych) do przeciwdziałania problemowi uzależnienia od dostawców (vendor lock-in) w sektorze oprogramowania B2B (business to business). W związku z tym międzynarodowe środowisko akademickie postuluje większą aktywność organów antymonopolowych w zapobieganiu problemowi vendor lock-in. Niektóre praktyki i klauzule stosowane na rynku oprogramowania B2B (również w Polsce) mogą spełniać przesłanki praktyk zakazanych przez prawo antymonopolowe (np. klauzule wyłącznościowe, wiązanie, sprzedaż pakietowa, rabaty lojalnościowe, odmowa udzielenia licencji lub informacji o interoperacyjności). Prawo konkurencji może dostarczyć zamawiającym lub konkurentom narzędzi do kwestionowania określonych klauzul umownych sprzedawców (np. w umowach o wdrożenie oprogramowania) lub do wpłynięcia na zmianę ich praktyk rynkowych, lub nawet do żądania zwrotu poniesionych opłat (np. za usługi serwisowe). Sprzedawcy oprogramowania powinni monitorować, czy niektóre ze stosowanych przez nich klauzul umownych lub praktyk rynkowych mogą naruszać prawo konkurencji i przedsięwziąć środki w celu obniżenia powyższego ryzyka. Możliwość zastosowania prawa konkurencji będzie zależeć od okoliczności konkretnej sprawy, dlatego każdy przypadek vendor lock-in powinien być analizowany odrębnie, m.in. pod kątem rynku właściwego, siły rynkowej oraz antykonkurencyjnych skutków danej praktyki lub klauzuli umownej.
Trouver l’intrus dans l’affaire Sharp : la Cour suprême face aux rapports entre le droit international privé, le droit public et le test du lien suffisant
Authors: Chikoc Barreda Naivi
Published: December 2024

Dans l’affaire Sharp, la Cour suprême du Canada est confrontée aux rapports entre le droit international privé, le droit public et le test d’interprétation du champ d’application territoriale des lois. En déclarant l’applicabilité des règles de compétence internationale du Code civil du Québec à une demande de l’AMF pour imposer des sanctions administratives en vertu de la Loi sur les valeurs mobilières, la Cour rejette le postulat selon lequel le droit international privé a pour objet les rapports internationaux de droit privé. Ce texte défend la position contraire, en proposant une analyse critique de la démarche suivie pour déterminer la compétence du TAMF en vertu du Code civil et du rapport de complémentarité que la Cour suprême du Canada a trouvé entre le droit international privé et le test du lien suffisant de l’arrêt Unifund.
Art/Design Education Resiliency: "Staying with the Trouble"
Authors: Patterson Pam
Published: December 2024

Art/Design Education Resiliency: “Staying with the Trouble” references Donna Haraway’s call to commit to, and persevere in, realising connections as kin in a distressed world. Pam Patterson reviews a community research project, COVID-Anxiety, looking at the promise of laterally structured and collegially organized art educational communities of practice. Independent self-facilitated research communities such as these composed of students, staff, and faculty can inform research and build capacity for practice in art education. Comparing this success to the failed establishment of a Disability Caucus that followed, she pursues an explicatory reflective writing that locates her study in time, place, and situation. She further uses these reflections to develop a metatext that identifies a theory around dialogic/dialect process use for the establishment – and potential success – of co-learning art and design educational communities of practice (CoPs).
What is the Impact of Online Hate?
Authors: Doyon Natasha
Published: December 2024

This is an arts-based action research (ABAR) project on how online/offline hate speech impacts new immigrant and refugee youth. Using a non-experimental qualitative arts-based approach, the youth participants developed digital literacy skills to create alternative narratives by transforming online images, text, and symbols into comics as new narratives. By working within a feminist and critical theoretical framework this project aimed to amplify the marginalized voices of youth through participatory art workshops, skill building, group discussions, and semi-structured interviews. In order to diffuse systemic inequalities and racism this research aims to build bridges between youth’s engagement with social media and their embodied knowledge towards fostering a new sense of belonging in their online/offline communities.
Craft Revival and Self-Directed Learning Among Young Women During the Pandemic
Authors: Pearson Sarah
Published: December 2024

This article aims to summarize a grounded theory inquiry to examine renewed interests in craft practices. Through remote interviews with female participants in their early twenties, and several rounds of data coding three emergent themes were identified: moving beyond traditional learning trajectories, art as function, and implications for sustainability. Investigating what motivates these women to engage creatively, and how they gained knowledge about their chosen mode of creative production, this inquiry reveals the self-directed nature of craft learning. Self-directed learning (SDL) is becoming more prevalent due to the increasing availability of resources and is therefore recognized for its validity as a contemporary learning approach. Especially relevant is the redemptive and autonomous qualities of both craft and self-directed learning in the context of the Covid-19 pandemic. This investigation cracks the surface of how craft-making and learning have been impacted by the pandemic, justifying the importance of independence, accessibility, and co-construction in teaching and learning.
The Value of Arts-Based Methods in STEM: Formal Analysis, Open Dialogue, and Subjectivity
Authors: Smylitopoulos Christina , Mousseau Sarah , Byrne-Mamahit Nakita , Oatley Sarah , Sutton Anna
Published: December 2024

In the Fall of 2021, STEM researchers were invited to participate in a series of SSHRC-funded workshops delivered at the University of Guelph’s School of Fine Art and Music (SOFAM), where they examined a work of abstract art drawn from the SOFAM Print Study Collection (Reflex Victory by Chrysanne Stathacos, lithograph, 1979). The project’s objective was to determine if methodologies used in the analysis and interpretation of art are helpful to researchers who use visual observation as a primary method of collecting data. Our findings indicate that over the duration of the one-hour workshop, participants demonstrated greater confidence in identifying what lay in their fields of vision with precision, exhibited greater comfort in pursuing open-ended inquiry, and became more conscious of the mutable and subjective qualities of their looking. This report shares the story of our experiment and presents our preliminary findings on the value of arts-based methodologies in developing skills in data collection and analysis. This research contributes to the discourse on the role visual art can play in practices of teaching, learning, and research that extend beyond the studio, museum, and gallery space.
Pre-service Elementary Generalist Teachers: Developing Competencies to Teach Visual Arts through the Studio Habits of Mind as a stance and artistic disposition
Authors: Tandon Shruti
Published: December 2024

This qualitative case study investigates the development of perceived competency for teaching visual art in pre-service generalist teachers and their readiness to use visual arts in their future elementary classrooms through a visual art methodology course. Pre-service generalist teachers’ feelings of preparedness and sense of efficacy are both important indicators of whether they will be able to meet the challenges of incorporating visual arts in their future classrooms and as effective 21st century educators. To achieve this aim, the study considered in-depth firsthand experiences of four pre-service teachers and their course instructor for the entire semester during their training. The uncertainty of understanding the role of visual arts in contemporary education, lack of personal confidence, and prior negative experience in visual arts are some of the contributing fear factors. Scholars suggest that this thinking can be changed through appropriate experiences, influences and environments provided during the pre-service training stage. Findings illustrate that pre-service teachers indicated an optimistic shift in their confidence to pursue visual arts with a refreshed mindset, by applying the Studio Habits of Mind within learning and teaching visual arts.
Primer hallazgo de Ascaris lumbricoides en un individuo del Calcolítico inicial en la Península Ibérica
Authors: López-Gijón Ramón , Duras Salvatore , Sánchez Susí Rafael , González Recio María Isabel , Rubio Salvador Ángel , Botella López Miguel Cecilio , Cámara Serrano Juan Antonio
Published: December 2024

La implementación de la agricultura y la ganadería en poblaciones neolíticas supuso un aumento exponencial de las parasitosis, a consecuencia de factores derivados de esta nueva estrategia socio-económica, como el hacinamiento, la explotación de la tierra y el contacto directo con animales domésticos y peridomésticos. Este trabajo presenta los resultados obtenidos en el estudio de sedimento procedente de un individuo fechado a finales del Neolítico, el cual fue localizado en el área de Los Pilares del yacimiento arqueológico del Polideportivo de Martos (Jaén, España). El análisis desarrollado mediante microscopía óptica ha evidenciado la presencia de Ascaris lumbricoides en la muestra pélvica. Este hallazgo supone la primera contribución de parásitos intestinales procedentes de restos esqueléticos neolíticos realizada en la península Ibérica, permitiendo individualizar la parasitosis y relacionar este hallazgo con las evidencias antropológicas.
Produzione e consumo di carne nella legislazione imperiale e ruolo del corpus suariorum
Authors: Biccari Maria Luisa
Published: December 2024

Abstract Starting with an analysis of the value that the meat market, especially pork, had in ancient Rome, the importance of the problem of its general supply and distribution is examined, with particular emphasis on the political and social role of the viscerationes, which became a public practice and a criterion of government within the annonary system. In particular, the titles De suariis, pecuariis et susceptoribus vini ceterisque corporatis of the Theodosian Code (C.Th. 14.4) and De suariis et susceptoribus vini et ceteris corporatis of the Justinian Code (C.I. 11.17) allow us to detect the commitment required of the corpus suariorum by the political bodies in relation to the payment of the canon suarius.
Ferdinando Zuccotti e l’Accademia Romanistica Costantiniana
Authors: Navarra Marialuisa
Published: December 2024

Abstract The following pages contain a brief outline of Ferdinando Zuccotti’s relationship with the ‘Accademia Romanistica Costantiniana’ alongside a review of his scientific contribution published in the Atti of the Research Center of the University of Perugia.
Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo
Authors: Al Asafen Hadel , Clark Natalie M , Goyal Etika , Jacobsen Thomas , Dima Sadia Siddika , Chen Hung-Yuan , Sozzani Rosangela , Reeves Gregory T
Published: December 2024

Morphogen-mediated patterning is a highly dynamic developmental process. To obtain an accurate understanding of morphogen gradient formation and downstream gene expression, biophysical parameters such as protein mobilities must be quantified
in vivo
. The dorsal-ventral (DV) patterning of early
Drosophila
embryos by the NF-κB homolog Dorsal (Dl) is an excellent system for understanding morphogen gradient formation. Dl gradient formation is controlled by the inhibitor Cactus/IκB (Cact), which regulates the nuclear import and diffusion of Dl protein. However, quantitative measurements of Dl mobility and binding are currently lacking. Here, we use scanning fluorescence correlation spectroscopy to quantify the mobility of GFP-tagged Dl. We find that the DNA binding of Dl-GFP, which affects its mobility, varies along the DV axis, with highest DNA binding on the ventral side. Moreover, we also observe that the time scale for Dl-GFP to exit the nucleus is longer in the ventral and lateral regions of the embryo, which is consistent with stronger DNA binding. Using analysis of mutant alleles of
dl
tagged with GFP, we conclude that Dl-GFP/Cact interactions in the nuclei are responsible for the variation in Dl-GFP/DNA binding along the DV axis, which impacts our understanding of the spatial range of the Dl gradient and the robustness and precision of downstream gene expression. Thus, our results highlight the complexity of morphogen gradient dynamics and the ability of quantitative measurements of biophysical interactions to drive biological discovery.
Does slow oscillation-spindle coupling contribute to sleep-dependent memory consolidation? A Bayesian meta-analysis
Authors: Ng Thea , Noh Eunsol , Spencer Rebecca MC
Published: December 2024

The active system consolidation theory suggests that information transfer between the hippocampus and cortex during sleep underlies memory consolidation. Neural oscillations during sleep, including the temporal coupling between slow oscillations (SO) and sleep spindles (SP), may play a mechanistic role in memory consolidation. However, differences in analytical approaches and the presence of physiological and behavioral moderators have led to inconsistent conclusions. This meta-analysis, comprising 23 studies and 297 effect sizes, focused on four standard phase-amplitude coupling measures including coupling phase, strength, percentage, and SP amplitude, and their relationship with memory retention. We developed a standardized approach to incorporate non-normal circular-linear correlations. We found strong evidence supporting that precise and strong SO-fast SP coupling in the frontal lobe predicts memory consolidation. The strength of this association is mediated by memory type, aging, and dynamic spatio-temporal features, including SP frequency and cortical topography. In conclusion, SO-SP coupling should be considered as a general physiological mechanism for memory consolidation.
High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
Authors: Howard Conor J , Abell Nathan S , Osuna Beatriz A , Jones Eric M , Chan Leon Y , Chan Henry , Artis Dean R , Asfaha Jonathan B , Bloom Joshua S , Cooper Aaron R , Liao Andrew , Mahdavi Eden , Mohammed Nabil , Su Alan L , Uribe Giselle A , Kosuri Sriram , Dickel Diane E , Lubock Nathan B
Published: December 2024

Deep Mutational Scanning (DMS) is an emerging method to systematically test the functional consequences of thousands of sequence changes to a protein target in a single experiment. Because of its utility in interpreting both human variant effects and protein structure-function relationships, it holds substantial promise to improve drug discovery and clinical development. However, applications in this domain require improved experimental and analytical methods. To address this need, we report novel DMS methods to precisely and quantitatively interrogate disease-relevant mechanisms, protein-ligand interactions, and assess predicted response to drug treatment. Using these methods, we performed a DMS of the melanocortin-4 receptor (MC4R), a G protein-coupled receptor (GPCR) implicated in obesity and an active target of drug development efforts. We assessed the effects of >6,600 single amino acid substitutions on MC4R’s function across 18 distinct experimental conditions, resulting in >20 million unique measurements. From this, we identified variants that have unique effects on MC4R-mediated Gα
s
- and Gα
q
-signaling pathways, which could be used to design drugs that selectively bias MC4R’s activity. We also identified pathogenic variants that are likely amenable to a corrector therapy. Finally, we functionally characterized structural relationships that distinguish the binding of peptide versus small molecule ligands, which could guide compound optimization. Collectively, these results demonstrate that DMS is a powerful method to empower drug discovery and development.
Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells
Authors: Wang Zijing , Xia Bihan , Qi Shaochong , Zhang Xian , Zhang Xiaoshuang , Li Yan , Wang Huimin , Zhang Miao , Zhao Ziyi , Kerr David , Yang Li , Cai Shijie , Yang Jilin
Published: December 2024

Bestrophin isoform 4 (BEST4) is a newly identified subtype of the calcium-activated chloride channel family. Analysis of colonic epithelial cell diversity by single-cell RNA-sequencing has revealed the existence of a cluster of BEST4+ mature colonocytes in humans. However, if the role of BEST4 is involved in regulating tumour progression remains largely unknown. In this study, we demonstrate that BEST4 overexpression attenuates cell proliferation, colony formation, and mobility in colorectal cancer (CRC) in vitro, and impedes the tumour growth and the liver metastasis in vivo. BEST4 is co-expressed with hairy/enhancer of split 4 (HES4) in the nucleus of cells, and HES4 signals BEST4 by interacting with the upstream region of the BEST4 promoter. BEST4 is epistatic to HES4 and downregulates TWIST1, thereby inhibiting epithelial-to-mesenchymal transition (EMT) in CRC. Conversely, knockout of BEST4 using CRISPR/Cas9 in CRC cells revitalises tumour growth and induces EMT. Furthermore, the low level of the BEST4 mRNA is correlated with advanced and the worse prognosis, suggesting its potential role involving CRC progression.
Mapping spatial patterns to energetic benefits in groups of flow-coupled swimmers
Authors: Heydari Sina , Hang Haotian , Kanso Eva
Published: December 2024

The coordinated motion of animal groups through fluids is thought to reduce the cost of locomotion to individuals in the group. However, the connection between the spatial patterns observed in collectively moving animals and the energetic benefits at each position within the group remains unclear. To address this knowledge gap, we study the spontaneous emergence of cohesive formations in groups of fish, modeled as flapping foils, all heading in the same direction. We show in pairwise formations and with increasing group size that (1) in side-by-side arrangements, the reciprocal nature of flow coupling results in an equal distribution of energy requirements among all members, with reduction in cost of locomotion for swimmers flapping inphase but an increase in cost for swimmers flapping antiphase, and (2) in inline arrangements, flow coupling is non-reciprocal for all flapping phase, with energetic savings in favor of trailing swimmers, but only up to a finite number of swimmers, beyond which school cohesion and energetic benefits are lost at once. We explain these findings mechanistically and we provide efficient diagnostic tools for identifying locations in the wake of single and multiple swimmers that offer opportunities for hydrodynamic benefits to aspiring followers. Our results imply a connection between the resources generated by flow physics and social traits that influence greedy and cooperative group behavior.
Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes
Authors: Shugarts Nathan , Sathya Aishwarya , Yi Andrew L , Chan Winnie M , Marré Julia A , Jose Antony M
Published: December 2024

RNAs in circulation carry sequence-specific regulatory information between cells in plant, animal, and host-pathogen systems. Such RNA can cross generational boundaries, as evidenced by somatic double-stranded RNA (dsRNA) in the nematode
C. elegans
silencing genes of matching sequence in progeny. Here we dissect the intergenerational path taken by dsRNA from parental circulation and discover that cytosolic import through the dsRNA importer SID-1 in the parental germline and/or developing progeny varies with developmental time and dsRNA substrates. Loss of SID-1 enhances initiation of heritable RNA silencing within the germline and causes changes in the expression of the

s

id-1
-
d
ependent
g
ene
sdg-1
that last for more than 100 generations after restoration of SID-1. The SDG-1 protein is enriched in perinuclear germ granules required for heritable RNA silencing but is expressed from a retrotransposon targeted by such silencing. This auto-inhibitory loop suggests how retrotransposons could persist by hosting genes that regulate their own silencing.
Liberdade humana e graça: um diálogo entre Edith Stein e Karl Rahner
Authors: Barbosa da Silva Washington Luiz , Bingemer Maria Clara Lucchetti
Published: December 2024

La gracia, como don inmerecido, se constituye en la ofrenda mui gratuita del Dios Trino al ser humano. Además, al ser creada libre, la persona humana recibió una disposición interior para “escuchar” la Revelación; por otra parte, por ser sobrenatural e indebido, ejerce el uso de su libertad. Al mismo tiempo, tal exigencia deja a la gracia “rehén” de su criatura; porque, en el camino, puede que os encontréis con el único obstáculo a la omnipotencia divina: la libertad humana. El único objetivo de este artículo es exponer el tema de la libertad humana y la gracia, dentro de la interdisciplinariedad entre filosofía cristiana, en antropología – con un enfoque fenomenológico –, de la filósofa Edith Stein (primera sección) y la antropología trascendental de lo teológo Karl Rahner, en su concepto de Existencial sobrenatural (segunda sección). Como resultado, se suscitará una comprensión sobre la existencia de una comunión entre libertad y gracia, en lugar de la competencia que todavía se proclama hoy. De esta unión surge la liberación humana de la oposición a Dios, como prisión en el propio “yo”, marcando la estructura interna humana de apertura y aceptación de la oferta divina.
Edith Stein y la manualística tomista de principios del siglo XX
Authors: Álvarez-Gutiérrez Rodrigo Gonzalo
Published: December 2024

La relación entre Edith Stein y el pensamiento tomasiano de principios del siglo XX podría configurarse como un intento de diálogo reflexivo entre posiciones que abordan las mismas cuestiones, pero con premisas metodológicas distintas. Cabe señalar que el componente biográfico de la pensadora no se puede soslayar en este asunto, pues academia y vida se fundan en el intento veritativo de la misma. Por ello, su relación con la manualística tomista es relevante para descubrir que es lo propio de su pensamiento, que la diferencia del Aquinate y cuál es su relación con el pensamiento surgido de la reflexión sobre este autor medieval.
A geração z chega à universidade: características socioeconômicas dos possíveis concluintes de cursos superiores no Brasil entre 2017 e 2019
Authors: Silva Mariana Domingues Gonçalves da , Kuwahara Mônica Yukie
Published: December 2024

Apesar da expansão das matrículas no ensino superior, o acesso às universidades continua restrito a algumas parcelas da população. O objetivo deste artigo é descrever as características dos estudantes do ensino superior que finalizaram seus cursos às vésperas da crise sanitária, em especial, os que compõem a chamada Geração Z. Utilizando dados do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (Inep) busca-se identificar a presença de desigualdades no acesso ao ensino superior para refletir sobre a importância de políticas afirmativas na ampliação das oportunidades dos jovens. A abordagem das capacitações, de Amartya Sen e Martha Nussbaum, é adotada por destacar a importância da educação para a autonomia.
Moderating Role of Data Driven Decision Making on the Relationship between Reverse Logistics and Firm Performance - A Development of Conceptual Framework
Authors: Krishnan S. Gokula , K L Arundathi,
Published: December 2024

The growing emphasis on sustainability in Supply Chain Management (SCM) has highlighted reverse logistics (RL) as a critical strategy for achieving both environmental and economic objectives. However, existing studies often overlook the moderating role of Data-Driven Decision-Making (DDDM) in enhancing the relationship between RL and firm performance. This study addresses this gap by proposing a conceptual framework that integrates RL, sustainability, profitability, and DDDM to optimize reverse logistics operations and bolster firm performance.
Drawing on a synthesis of existing literature, the study identifies key challenges in RL, including inefficiencies in recovery and recycling processes, and proposes data-centric strategies to address these issues. The conceptual framework illustrates how leveraging DDDM enables firms to analyze large datasets, streamline RL processes, and ensure alignment with sustainability goals. By integrating data-driven insights, organizations can improve operational agility, reduce costs, and achieve compliance with environmental regulations, ultimately enhancing profitability and competitive positioning.
The methodology focuses on developing a theoretically grounded framework that lays the foundation for future empirical validation. Key results suggest that firms employing DDDM in RL processes can significantly reduce waste, lower carbon footprints, and create value through efficient resource use. This research provides actionable insights for managers and policymakers, advocating for the integration of DDDM to transform RL into a strategic driver of sustainability and profitability.
This article holds significant importance for the scientific community as it addresses the critical intersection of reverse logistics, sustainability, and profitability, a growing area of interest in both academia and industry. By integrating the role of data-driven decision-making, the study provides a novel conceptual framework that can enhance operational efficiency and promote sustainable business practices. This study not only contributes to the theoretical advancement of reverse logistics and sustainability but also offers practical insights for organizations striving to balance economic and environmental objectives. Furthermore, it highlights the transformative potential of data analytics in driving sustainable supply chain strategies, making it a valuable resource for researchers and practitioners alike.