Weight Change and the Risk of Micro and Macro Vascular Complications of Diabetes: A Systematic Review
Authors: Sadat Rafiei Seyyed Kiarash ,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Fateh Fardad , Arab Mahla , Espanlo Mohammad , Dahaghin Saba , Karami Gilavand Helia , Shahrokhi Mehregan , Fallahi Mohammad Sadegh , Zardast Zahra , Ansari Arina , Seifhashemi Seyyed Alireza , Kheirandish Ali , Erabi Gisou , Hajikolaei Ahmadi , Nakhaee Mahdi , Deravi Niloofar ,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   School of Medicine, Tehran University of Medical Sciences, Tehran, Iran,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran,   School of Medicine, Tehran University of Medical Sciences, Tehran, Iran,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran,   Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran,   School of Medicine, Babol University of Medical Sciences, Babol, Iran,   Department of Laboratory Medicine, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Published: July 2024

Type 2 diabetes mellitus (T2DM) is a metabolic disease that can be a significant cause of cardiovascular disease (CVD), leading to macrovascular and microvascular diseases. Many researchers around the world have investigated the effects of weight change on micro and macro CVD in patients with T2DM. This study aimed to investigate the effect of weight change (weight gain and loss) on microvascular and macrovascular complications in patients with T2DM. We searched PubMed, Scopus and Google Scholar from the database until January 2023. We screened the title, abstract, and full text of articles, and after quality assessment, we extracted data from interrelated ones into this systematic review. Reviewing the results of 11 cohort studies with 219,839 individuals (T2DM patients) showed that weight loss caused an increase in the mortality rate in diabetic patients, while weight gain after diabetes diagnosis increased the risk of CVD, chronic kidney disease (CKD), microvascular disease, stroke and mortality. It should be noted that severe body weight variability increases the mortality rate and the risk of microvascular disease. Unlike other studies, one study showed that more than 5% weight gain positively affected CVD and coronary heart disease in T2DM patients. Generally, weight change in patients with T2DM is an essential sign of cardiovascular complications. According to our findings, the risk of cardiovascular complications in patients with weight loss is seen to be higher than in patients with weight gain. In regular patients with body mass index (BMI), stable weight in a healthy range is reported to decrease the risk of CVD.