bluuebunny/crossref_metadata_2025 huggingface dataset:
Primary congenital hypothyroidism: challenges in a low-income country without paediatric endocrinologist and universal newborn screening
Authors: Bin Sakviseth , Phou Kimyi , Im Sethikar
Published: May 2023

Due to the lack of public awareness, congenital hypothyroidism (CH) remains an overlooked challenge in Cambodia. This disease should be screened routinely at birth because, though asymptomatic, it can lead to mental retardation in the absence of early treatment. Since 2013, our unit has been the only centre that implements routine screening and provides treatment and follow-up. This case report highlights a long and tough journey of a girl who, after being diagnosed by routine newborn screening, came for follow-up at our centre. Since the screening has yet to be recognised nationally, we want to raise not only awareness of CH but also the difficulties faced by parents because their children are in need of life-long treatment in a low-resource country. Thus, the key to successful management of paediatric patients is their parental involvement, which can be influenced by their educational, cultural, geographical and financial background.
Anti-Yo paraneoplastic cerebellar degeneration in a patient with stage IV ovarian adenocarcinoma during bevacizumab maintenance therapy
Authors: Giucca Alice , Morrison Hamish , Wilson Thomas , Cossburn Mark
Published: May 2023

Anti-Yo paraneoplastic cerebellar degeneration (PCD) is a rare autoimmune neurological syndrome characterised by cerebellar symptoms and frequently associated with gynaecological malignancies. While typically preceding the diagnosis of the malignancy, rarely it may present later in the disease course, heralding a recurrence prior to biochemical or radiological confirmation. Disease management is challenging and prognosis remains poor.

We present the case of a woman with stage IV ovarian adenocarcinoma who developed anti-Yo PCD 16 months post malignancy diagnosis while receiving bevacizumab maintenance therapy. We review the literature and outline the difficulties in diagnosis and the frequently refractory nature of PCD to available treatments.
Pneumomediastinum complicating diabetic ketoacidosis
Authors: Zethof Siem , Borstlap Carmen , Vroomans Michel , Groenendijk Martijn
Published: May 2023

Pneumomediastinum is an uncommon finding in patients with diabetic ketoacidosis (DKA) and may occur spontaneously or secondary to an effort rupture of the oesophagus. Excluding oesophageal rupture is important, as delaying treatment increases the risk of mortality. We discuss a case of DKA complicated by vomiting, pneumomediastinum, pneumopericardium and air in the epidural space. Instead of fluoroscopic oesophagography, chest CT was used to investigate oesophageal rupture. We present an overview of case reports and retrospective studies illustrating the utility of chest CT in the investigation of oesophageal rupture over fluoroscopic oesophagography.
Third cranial nerve palsy due to COVID-19 infection
Authors: Iwasaki Monika , Nishizawa Toshinori , Iida Eiki , Arioka Hiroko
Published: May 2023

We report a case of a previously healthy man in his 40s who presented with mild SARS-CoV-2 infection (COVID-19) concomitant with acute onset of left third cranial nerve palsy with restricted supraduction, adduction and infraduction. Our patient did not present any history of hypertension, hyperlipidaemia, diabetes mellitus or smoking. The patient recovered spontaneously without any antiviral treatment. To our knowledge, this is the second report of third cranial nerve palsy spontaneously resolved without any risk factors of vascular disease, specific image findings, nor any possible causes other than COVID-19. In addition, we reviewed 10 other cases of third cranial nerve palsy associated with COVID-19, which suggested that the aetiology varies greatly. As a clinician, it is important to recognise COVID-19 as a differential diagnosis for third cranial nerve palsy. Finally, we aimed to encapsulate the aetiologies and the prognosis of the third cranial nerve palsy associated with COVID-19.
Factors that influence the uptake of postnatal care among adolescent girls: a qualitative evidence synthesis
Authors: Javadi Dena , Sacks Emma , Brizuela Vanessa , Finlayson Kenneth , Crossland Nicola , Langlois Etienne V , Ziegler Daniela , Chandra-Mouli Venkatraman , Bonet Mercedes
Published: May 2023

Background

Adolescent pregnancy is associated with increased risk of maternal and child morbidity and mortality globally. Access to safe, appropriate and affordable antenatal, childbirth and postnatal care (PNC) is essential in mitigating this risk. PNC is an often undervalued, underused, and understudied component of the continuum of maternal health services; however, it provides an important opportunity for adolescent girls to have access to health information and resources as they navigate the transition to motherhood and/or recovery from childbirth. This qualitative evidence synthesis seeks to highlight the experiences and perspectives of adolescent girls and their partners in accessing and using routine PNC.

Methods

Papers were selected from a primary review on PNC where a global search of databases was conducted to identify studies with qualitative data focused on PNC utilisation. Within this primary review, a subset of studies focused on adolescents was tagged for subanalysis. A data extraction form drawing on an a priori framework was used to extract data from each study. Review findings were grouped across studies and mapped onto relevant themes, which were then adapted, as appropriate, to best reflect emergent themes from included studies.

Results

Of 662 papers identified for full text review, 15 were included in this review on adolescents’ experiences. Fourteen review findings were mapped onto four themes including: resources and access, social norms, experiences of care, and tailored support needs.

Conclusion

Improving uptake of PNC by adolescent girls requires multipronged approaches in improving availability of and access to adolescent-sensitive maternal health services and reducing feelings of shame and stigma in the postpartum period. Much should be done to address structural barriers to access, but tangible steps to improving the quality and responsiveness of available services can be taken immediately.

PROSPERO registration number

CRD42019139183.
Implementation fidelity of the ‘Stay One Step Ahead’ home safety intervention: a mixed-methods analysis
Authors: Stewart Sabrina , Kendrick Denise , Watson Michael Craig , Hayes Mike , Orton Elizabeth
Published: May 2023

Objective

To assess implementation fidelity of the Stay One Step Ahead (SOSA), a complex intervention which was delivered by health visiting teams, children’s centres, and family mentors and was aimed at preventing unintentional home injuries in children under 5 in disadvantaged communities.

Study design

A mixed-methods evaluation of the implementation fidelity of the SOSA intervention.

Methods

A conceptual framework for implementation fidelity was used to triangulate data from questionnaires and semistructured interviews with parents and practitioners, observations of parent and practitioner contacts, and meeting documents. Quantitative data were analysed using logistic regression and descriptive statistics. Thematic analysis was used for qualitative data.

Results

Parents in intervention wards were more likely to receive home safety advice from a practitioner than those living in matched control wards. Monthly safety messages and family mentor home safety activities were delivered with greater fidelity than other intervention components. Content most frequently adapted included the home safety checklist used by health visiting teams, and safety weeks delivered at children’s centres.

Conclusion

Consistent with similarly complex interventions, SOSA was delivered with variable fidelity in a challenging environment. The findings add to the body of evidence on implementation fidelity of home injury prevention programmes, providing important information for future intervention development and delivery.
BCMA CAR-T induces complete and durable remission in refractory plasmablastic lymphoma
Authors: Raghunandan Sharmila , Pauly Melinda , Blum William G , Qayed Muna , Dhodapkar Madhav V , Elkhalifa Mohamed , Watkins Benjamin , Schoettler Michelle , Horwitz Edwin , Parikh Suhag , Chandrakasan Shanmuganathan , Leung Kathryn , Bryson Elyse , Deeb Laura , Kaufman Jonathan L , Worthington-White Diana , Alazraki Adina , Schecter Jordan M , Madduri Deepu , Jackson Carolyn C , Zudaire Enrique , Taraseviciute-Morris Agne , Babich Alexander , Nesheiwat Tonia , Vogel Martin , Lendvai Nikoletta , Pacaud Lida , Williams Kirsten M
Published: May 2023

Plasmablastic lymphoma (PBL) is a rare subtype of aggressive large B-cell lymphoma, with a dismal prognosis despite aggressive therapies. New approaches are needed for those with refractory disease. PBL expresses antigens similar to multiple myeloma (MM), including B-cell maturation antigen (BCMA). Chimeric antigen receptor T-cell (CAR-T) therapy directed against BCMA has shown efficacy for the treatment of heavily pretreated MM with low rates of grades 3 and 4 cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) in a phase Ib/II trial (A Study of JNJ-68284528, a CAR-T Directed Against BCMA in Participants With Relapsed or Refractory Multiple Myeloma (CARTITUDE-1),NCT03548207). However, data for the use of BCMA CAR-T for treating PBL are lacking.

We report a challenging case of multiple refractory PBL that emerged from B-cell acute lymphoblastic leukemia in an adolescent who failed to respond to an allogeneic hematopoietic cell transplant. The patient developed rapidly advancing disease despite withdrawal of immunosuppression, treatment with etoposide, ibrutinib, and daratumumab, prompting consideration of BCMA CAR-T (under emergency investigational new drug (eIND)). The patient achieved a complete remission (CR), without recurrent acute graft versus host disease (GVHD), CRS or ICANS after BCMA CAR-T therapy. BCMA CAR-T expansion was detected in vivo, peaking on day 15. The patient remains in CR for more than a year post CAR-T therapy, supporting consideration of immunotherapy for future patients with refractory PBL, a disease with few treatment options.
‘False hope’ in assisted reproduction: the normative significance of the external outlook and moral negotiation
Authors: Accoe Dorian , Segers Seppe
Published: May 2023

Despite the frequent invocation of ‘false hope’ and possible related moral concerns in the context of assisted reproduction technologies, a focused ethical and conceptual problematisation of this concept seems to be lacking. We argue that an invocation of ‘false hope’ only makes sense if the fulfilment of a desired outcome (eg, a successful fertility treatment) is impossible, and if it is attributed from an external perspective. The evaluation incurred by this third party may foreclose a given perspective from being an object of hope. However, this evaluation is not a mere statistical calculation or observation based on probabilities but is dependent on several factors that should be acknowledgeable as morally relevant. This is important because it allows room for, and encourages, reasoned disagreement and moral negotiation. Accordingly, the object of hope itself, whether or not based on socially embedded desires or practices, can be a topic of debate.
Identification of an increased lifetime risk of major adverse cardiovascular events in UK Biobank participants with scoliosis
Authors: Quintero Santofimio Valentina , Clement Adam , O’Regan Declan P , Ware James S , McGurk Kathryn A
Published: May 2023

Background

Structural changes caused by spinal curvature may impact the organs within the thoracic cage, including the heart. Cardiac abnormalities in patients with idiopathic scoliosis are often studied post-corrective surgery or secondary to diseases. To investigate cardiac structure, function and outcomes in participants with scoliosis, phenotype and imaging data of the UK Biobank (UKB) adult population cohort were analysed.

Methods

Hospital episode statistics of 502 324 adults were analysed to identify participants with scoliosis. Summary 2D cardiac phenotypes from 39 559 cardiac MRI (CMR) scans were analysed alongside a 3D surface-to-surface (S2S) analysis.

Results

A total of 4095 (0.8%, 1 in 120) UKB participants were identified to have all-cause scoliosis. These participants had an increased lifetime risk of major adverse cardiovascular events (MACEs) (HR=1.45, p<0.001), driven by heart failure (HR=1.58, p<0.001) and atrial fibrillation (HR=1.54, p<0.001). Increased radial and decreased longitudinal peak diastolic strain rates were identified in participants with scoliosis (+0.29, Padj<0.05; −0.25, Padj<0.05; respectively). Cardiac compression of the top and bottom of the heart and decompression of the sides was observed through S2S analysis. Additionally, associations between scoliosis and older age, female sex, heart failure, valve disease, hypercholesterolemia, hypertension and decreased enrolment for CMR were identified.

Conclusion

The spinal curvature observed in participants with scoliosis alters the movement of the heart. The association with increased MACE may have clinical implications for whether to undertake surgical correction. This work identifies, in an adult population, evidence for altered cardiac function and an increased lifetime risk of MACE in participants with scoliosis.
Document analysis of the Foundation for a Smoke-Free World’s scientific outputs and activities: a case study in contemporary tobacco industry agnogenesis
Authors: Legg Tess , Clift Bryan , Gilmore Anna B
Published: May 2023

Background

Tobacco corporation Philip Morris International launched the Foundation for a Smoke-Free World (FSFW), a purportedly independent scientific organisation, in 2017. We aimed to systematically investigate FSFW’s activities and outputs, comparing these with previous industry attempts to influence science, as identified in the recently developed typology of corporate influence on science, the Science for Profit Model (SPM).

Design

We prospectively collected data on FSFW over a 4-year period, 2017–2021, and used document analysis to assess whether FSFW’s activities mirror practices tobacco and other industries have historically used to shape science in their own interests. We used the SPM as an analytical framework, working deductively to search for use of the strategies it identifies, and inductively to search for any additional strategies.

Results

Marked similarities between FSFW’s practices and previous corporate attempts to influence science were observed, including: producing tobacco industry-friendly research and opinion; obscuring industry involvement in science; funding third parties which denigrate science and scientists that may threaten industry profitability; and promoting tobacco industry credibility.

Conclusions

Our paper identifies FSFW as a new vehicle for agnogenesis, indicating that, over 70 years since the tobacco industry began to manipulate science, efforts to protect science from its interference remain inadequate. This, combined with growing evidence that other industries are engaging in similar practices, illustrates the urgent need to develop more robust systems to protect scientific integrity.
NLO QCD corrections to off-shell top–antitop production with semi-leptonic decays at lepton colliders
Authors: Denner Ansgar , Pellen Mathieu , Pelliccioli Giovanni
Published: May 2023

The study of top-quark properties will be a central aspect of the physics programme of any future lepton collider. In this article, we investigate the production of top-quark pairs in the semi-leptonic decay channel in $${\textrm{e}}^{+}\textrm{e}^{-}$$

e

+

e
-

collisions, whose experimental signature is one charged lepton, jets, and missing energy. We present for the first time fiducial cross sections and differential distributions at next-to-leading-order accuracy in QCD for the full off-shell process. We find that the QCD corrections for the considered process are strongly dependent on the beam energies and range from few per cent up to more than $$100\%$$

100
%

(near threshold and above $$1\,\text {TeV} $$

1

TeV

). We focus, in particular, on two scenarios: one close to threshold ($$365\,\text {GeV} $$

365

GeV

), dominated by top-pair production, and one at the TeV scale ($$1.5\,\text {TeV} $$

1.5

TeV

), for which irreducible-background contributions become relevant. An assessment of polarised-beam effects is also provided.
Unpaired Self-supervised Learning for Industrial Cyber-Manufacturing Spectrum Blind Deconvolution
Authors: Deng Lizhen , Xu Guoxia , Pi Jiaqi , Zhu Hu , Zhou Xiaokang
Published: May 2023

Cyber-Manufacturing combines industrial big data with intelligent analysis to find and understand the intangible problems in decision-making, which requires a systematic method to deal with rich signal data. With the development of spectral detection and photoelectric imaging technology, spectral blind deconvolution has achieved remarkable results. However, spectral processing is limited by one-dimensional signal, and there is no available structural information with few training samples. Moreover, in the majority of practical applications, it is entirely feasible to gather unpaired spectrum dataset for training. This training method of unpaired learning is practical and valuable. Therefore, a two-stage deconvolution scheme combining self supervised learning and feature extraction is proposed in this paper, which generates two complementary paired sets through self supervised learning to extract the final deconvolution network. In addition, a new deconvolution network is designed for feature extraction. The spectrum is pre-trained through spectral feature extraction and noise estimation network to improve the training efficiency and meet the assumed noise characteristics. Experimental results show that this method is effective in dealing with different types of synthetic noise.
DevEx: What Actually Drives Productivity
Authors: Noda Abi , Storey Margaret-Anne , Forsgren Nicole , Greiler Michaela
Published: May 2023

Developer experience focuses on the lived experience of developers and the points of friction they encounter in their everyday work. In addition to improving productivity, DevEx drives business performance through increased efficiency, product quality, and employee retention. This paper provides a practical framework for understanding DevEx, and presents a measurement framework that combines feedback from developers with data about the engineering systems they interact with. These two frameworks provide leaders with clear, actionable insights into what to measure and where to focus in order to improve developer productivity.
A mild and transient form of autosomal recessive pseudohypoaldosteronism type 1 caused by a novel mutation in the SCNN1A gene
Authors: Efthymiadou Alexandra , Gautschi Ivan , van Bemmelen Miguel Xavier , Sertedaki Amalia , Giannakopoulos Aristeidis , Chrousos George , Schild Laurent , Chrysis Dionisios
Published: May 2023

This paper demonstrates that mild autosomal recessive pseudohypoaldosteronism type 1 (PHA1) due to p.Phe226Cys missense mutation in the extracellular domain of ENαC α subunit can be transient, with phenotypic variability even with the normal sweat test, and incomplete penetrance. Functional studies explain the phenotype and denote the importance of the location on the extracellular domain of the SCNN1A p.Phe226Cys mutation for the intrinsic ENaC activity and the channel expression at the protein level.
Low Total Testosterone Levels in Men with Newly Diagnosed Early-Onset Type 2 Diabetes: A Cross-Sectional Study in China
Authors: Hu Yun , Yuan Lu , Bao Yu-jie , Wang Ying , Cai Ting-ting , Ma Jian-hua , Ding Bo
Published: May 2023

Objective. There is a bidirectional interaction between circulating testosterone and blood glucose levels. We aim to investigate the testosterone levels in men with early-onset type 2 diabetes (T2DM). Methods. A total of 153 drug naive men with T2DM were enrolled in the study. Early- (

n
=
63

) and late-onset (

n
=
90

) T2DM was classified according to age 40 years old. Clinical characteristics and plasma for biochemical criterions were collected. Gonadal hormones were measured using chemiluminescent immunometric assay. The concentrations of 3β- and 17β-HSD were determined using ELISA. Results. Compared with men with late-onset T2DM, those with early-onset T2DM had lower serum total testosterone (TT), sex hormone-binding globulin (SHBG), and FSH, but higher dehydroepiandrosterone sulfate (DHEA-S) level (

p
<
0.05

). The mediating effect analysis showed that the decreased TT levels in patients with early-onset T2DM were associated with the higher HbA1c, BMI, and triglyceride in these patients (both

p
<
0.05

). The early-onset of T2DM directly correlated with increased DHEA-S (both

p
<
0.01

). The 3β-HSD concentration in the early-onset T2DM group was lower than that in the late-onset T2DM group (

11.07
±
3.05

vs.

12.40
±
2.72

 pg/mL,

p
=
0.048

) and was positively correlated with fasting C-peptide, while negatively correlated with HbA1c and fasting glucagon (

p

all < 0.05). Conclusions. Patients with early-onset T2DM showed inhibition of conversion from DHEA to testosterone, which may attribute to the low level of 3β-HSD and high blood glucose in these patients.
Modified Tunnel Procedure to Facilitate Ridge Reconstruction of an Extraction Socket Associated with Buccal Dehiscence and Gingival Recession: A Case Report with a 6-year Follow-Up
Authors: Ascenzi Felice , Hosein Andrell , Lu Emily Ming-Chieh
Published: May 2023

Introduction. Extraction sockets associated with buccal dehiscences and gingival recessions pose particular surgical and restorative challenges. In these cases, unassisted healing following flapless tooth extraction results in severe bone and soft tissue deformities and an aesthetic compromise. Root coverage procedures prior to ridge reconstruction may enable predictable alveolar augmentation. Case Presentation. This is the first case report describing the utilisation of modified tunnel procedure to facilitate ridge reconstruction consisting of ovate pontic and xenograft, of tooth #25 in a 38-year-old-male. The 6 months and 1-year reviews showed optimal soft tissue aesthetics, 100% root coverage of the tooth #25, and bone augmentation, which enabled placement of

10.0
 
mm
×
4.0
 
mm

(3i) implant in a prosthetically driven position. The 6-year review continued to show favourable clinical outcomes. Conclusion. Compromised extraction sockets containing buccal dehiscence and associated with gingival recessions may benefit from soft tissue augmentation procedures to enhance the clinical outcome of ridge reconstruction.
Autophagy and Its Lineage-Specific Roles in the Hematopoietic System
Authors: Hasan Kazi Md Mahmudul , Haque Md Anwarul
Published: May 2023

Autophagy is a dynamic process that regulates the selective and nonselective degradation of cytoplasmic components, such as damaged organelles and protein aggregates inside lysosomes to maintain tissue homeostasis. Different types of autophagy including macroautophagy, microautophagy, and chaperon-mediated autophagy (CMA) have been implicated in a variety of pathological conditions, such as cancer, aging, neurodegeneration, and developmental disorders. Furthermore, the molecular mechanism and biological functions of autophagy have been extensively studied in vertebrate hematopoiesis and human blood malignancies. In recent years, the hematopoietic lineage-specific roles of different autophagy-related (ATG) genes have gained more attention. The evolution of gene-editing technology and the easy access nature of hematopoietic stem cells (HSCs), hematopoietic progenitors, and precursor cells have facilitated the autophagy research to better understand how ATG genes function in the hematopoietic system. Taking advantage of the gene-editing platform, this review has summarized the roles of different ATGs at the hematopoietic cell level, their dysregulation, and pathological consequences throughout hematopoiesis.
Profanity as a Self-Defense Mechanism and an Outlet for Emotional Catharsis in Stress, Anxiety, and Depression
Authors: Husain Waqar , Wasif Samia , Fatima Insha
Published: May 2023

Background. Swearing is an increasing trend among men and women worldwide. Earlier studies on the positive aspects of profanity mostly relate to pain management and the release of negative emotions. The uniqueness of the current study is its analysis for a possible constructive role of profanity in stress, anxiety, and depression. Method. The current survey involved 253 conveniently selected participants from Pakistan. The study analyzed the role of profanity in connection to stress, anxiety, and depression. Profanity Scale and the Urdu version of Depression, Anxiety, and Stress Scale were used along with a structured interview schedule. Descriptive statistics, Pearson’s correlation coefficient, and

t

-test were implied to obtain results. Results. The study revealed that the usage of profane language had significantly inverse correlations with stress (

r
=
−
0.250

;

p
<
0.01

), anxiety (

r
=
−
0.161

;

p
<
0.05

), and depression (

r
=
−
0.182

;

p
<
0.01

). Higher profaners also revealed significantly lower levels of depression (

M
=
29.91

,

SD
=
10.80

vs.

M
=
33.48

,

SD
=
10.40

;

p
=
0.009

; Cohen’s

d
=
0.338

) and stress (

M
=
30.83

,

SD
=
11.41

vs.

M
=
35.16

,

SD
=
11.31

;

p
=
0.003

; Cohen’s

d
=
0.381

) as compared to lower profaners. Profanity had no significant correlations with age (

r
=
0.031

;

p
>
0.05

) and education (

r
=
0.016

;

p
>
0.05

). Men projected significantly higher levels of profanity as compared to women. Conclusion. The current study viewed profanity similar to the self-defense mechanisms and emphasized on its cathartic role in stress, anxiety, and depression.
The Accurate Interpretation and Clinical Significance of Morphological Features of Fine Needle Aspiration Cells in Papillary Thyroid Carcinoma
Authors: Xiong Xue-Jiao , Xiao Ming-Ming , Zhang Yi-Xia , Liu Dong-Ge , Jin Mu-Lan , Wang Jian , Xu Hong-Tao , Li Qing-Chang , Wu Guang-Ping
Published: May 2023

Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid gland; fine needle aspiration cytology is the most basic and reliable diagnostic method before PTC operation. However, it is not clear which cell morphological changes can be used as a reliable standard for the diagnosis of PTC. A retrospective analysis was performed on 337 patients with PTC confirmed by postoperative histology. An additional 197 randomly selected patients with benign thyroid lesions were included in the study and used as a control group. True papillary arrangements, swirl arrangements, and escape arrangements had high specificity, all of which were 100%, but only swirl arrangements had ideal sensitivity (77.61%). The nuclear volume characteristics had a high sensitivity of more than 90%, but the specificities of both nuclear crowding and nuclear overlap were too low, only 16.34% and 23.35%. The sensitivities of five nuclear structural characteristics were more than 90%, but only the specificity of intranuclear cytoplasmic pseudoinclusions (INCIs) reached 100%, nuclear contour irregularity and pale nuclei with powdery chromatin also had ideal interpretation value except for grooves and marginally placed micronucleoli. Although the sensitivity of psammoma bodies (PBs) was low, the specificity was 100%. In terms of preparation methods, the method of liquid‐based preparation (LBP) is obviously better than that of conventional smears. The diagnostic efficiency by the combined detection method of parallel tests showed that without reducing the specificity, the sensitivity increased with the increase of the number of morphological characteristics and finally reached 98.81%. The INCIs and swirl arrangements are the most common and important indicators for the diagnosis of PTC, whereas papillary‐like arrangements, the crowding and overlap of nuclear, grooves, marginally placed micronucleoli, and multinucleated giant cells are of little significance for the diagnosis of PTC.
Short-Term Passenger Flow Forecasting for Rail Transit considering Chaos Theory and Improved EMD-PSO-LSTM-Combined Optimization
Authors: Zhao Lixin , Jin Hui , Zou Xintong , Liu Xiao
Published: May 2023

This paper proposes a prediction method based on chaos theory and an improved empirical-modal-decomposition particle-swarm-optimization long short-term-memory (EMD-PSO-LSTM)-combined optimization process for passenger flow data with high nonlinearity and dynamic space-time dependence, using EMD to process the original passenger flow data and generate several eigenmodal functions (IMFs) and residuals with different characteristic scales. Based on the chaos theory, each component of the PSO algorithm was improved by introducing an inertia factor to facilitate the adjustment of its search capability to improve optimization. Each subsequence of the phase-space reconstruction was built into an improved PSO-LSTM prediction model, and the output of each prediction model was summed to determine the final output. Experimental studies were performed using data from the North Railway Station of Chengdu Rail Transit, and the results showed that the proposed model can generate better prediction results. The proposed model obtained root mean square error (RMSE) and mean absolute error (MAE) of 16.0908 and 11.3704, respectively. Compared with the LSTM, the improved PSO-LSTM, the improved EMD-PSO-LSTM, and the model proposed in this paper improved the RMSE values by 25.53%, 29.97%, and 58.76%, respectively, and the MAE values by 30.41%, 40.13%, and 63.08%, respectively, of the prediction results.
An Underwater Target Tracking Algorithm Based on Extended Kalman Filter
Authors: Huang Jian
Published: May 2023

The technology of ocean monitoring is more advanced while the continuous development of industrial Internet. Unmanned underwater vehicle (UUV) is one of major ways for underwater environment monitoring, which makes high-precision positioning, and tracking of it is one of the key problems and needs to be solved urgently. An underwater acoustic positioning and tracking algorithm based on multiple beacons is proposed to reduce the positioning error of underwater acoustic positioning system caused by uncertain sound speed. The system consists of multiple GPS intelligent buoys floated on the sea surface and acoustic signal generator installed on the UUV. The effective sound speeds between the UUV and different buoys are considered to be unequal and estimated as the state parameters, together with the kinematic parameters of the UUV. Based on the kinematic equations of the UUV, the tracking model is obtained under the framework of the extended Kalman filter. Simulation results show that the proposed algorithm can correct the sound speed and improve the stability and accuracy of underwater acoustic positioning system.
Supplementary Table S3 from Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
Authors: Sekhar Konjeti R. , Freeman Michael L.
Published: May 2023

List of Small Molecule NPM1 Inhibitors discussed in paper.
Data from Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance
Authors: Zhuang Junlong , Shen Lan , Li Meiqian , Sun Jingya , Hao Jiange , Li Jiaxuan , Zhu Zhen , Ge Shuning , Zhang Dianzheng , Guo Hongqian , Huang Ruimin , Yan Jun
Published: May 2023

Abstract
Cancer stem-like cells (CSCs) play pivotal roles in both chemoresistance and recurrence of many cancer types, including urothelial bladder cancer (UBC). In addition to intrinsic signaling pathways, extracellular cues from the tumor microenvironment (TME) are indispensable for the maintenance of CSCs. To better understand the mechanisms involved in TME-mediated generation and support of UBC CSCs, we focused on the role of cancer-associated fibroblasts (CAFs) in this study. Overexpression of miR-146a-5p in CAFs promoted CAF-to-UBC cell interactions, cancer stemness, and chemoresistance to treatment with gemcitabine and cisplatin. Mechanistically, miR-146-5p upregulated SVEP1 in CAFs by enhancing the recruitment of transcriptional factor YY1. Meanwhile, by targeting the 3’UTR of mRNAs of ARID1A and PRKAA2 (also known as AMPKα2) in UBC cells, CAF-secreted miR-146a-5p promoted cancer stemness and chemoresistance. Downregulation of ARID1A resulted in the inhibition of SOCS1 and subsequent STAT3 activation, and downregulated PRKAA2 led to the activation of mTOR signaling. Elevated levels of exosomal miR-146a-5p in the serum of UBC patients were correlated with both tumor stage and relapse risk. These findings altogether indicate that CAF-derived miR-146a-5p can promote stemness and enhance chemoresistance in UBC. Exosomal miR-146a-5p may be a biomarker of UBC recurrence and a potential therapeutic target.
Data from Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
Authors: Schwoerer Simon , Cimino Francesco V. , Ros Manon , Tsanov Kaloyan M. , Ng Charles , Lowe Scott W. , Carmona-Fontaine Carlos , Thompson Craig B.
Published: May 2023

Abstract
Cancer-associated fibroblasts (CAFs) are a major cell type in the stroma of solid tumors and can exert both tumor-promoting and tumor-restraining functions. CAF heterogeneity is frequently observed in pancreatic ductal adenocarcinoma (PDAC), a tumor characterized by a dense and hypoxic stroma that features myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs) that are thought to have opposing roles in tumor progression. While CAF heterogeneity can be driven in part by tumor cell-produced cytokines, other determinants shaping CAF identity and function are largely unknown. In vivo, we found that iCAFs displayed a hypoxic gene expression and biochemical profile and were enriched in hypoxic regions of PDAC tumors, while myCAFs were excluded from these regions. Hypoxia led fibroblasts to acquire an inflammatory gene expression signature and synergized with cancer cell-derived cytokines to promote an iCAF phenotype in a HIF-1α dependent fashion. Furthermore, HIF-1α stabilization was sufficient to induce an iCAF phenotype in stromal cells introduced into PDAC organoid co-cultures and to promote PDAC tumor growth. These findings indicate hypoxia-induced HIF-1α as a regulator of CAF heterogeneity and promoter of tumor progression in PDAC.
Supplementary Table S1 from The Association of Neighborhood Characteristics and Frailty in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort Study
Authors: Schwartz Lindsay F. , Dhaduk Rikeenkumar , Howell Carrie R. , Brinkman Tara M. , Ehrhardt Matthew J. , Delaney Angela , Srivastava Deo Kumar , Lanctot Jennifer Q. , Armstrong Gregory T. , Robison Leslie L. , Hudson Melissa M. , Ness Kirsten K. , Henderson Tara O.
Published: May 2023

Supplementary Table S1 shows the differences in frailty status breakdowns for the SJLIFE community control cohort versus our study participants (N=3806)
Data from The Association of Neighborhood Characteristics and Frailty in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort Study
Authors: Schwartz Lindsay F. , Dhaduk Rikeenkumar , Howell Carrie R. , Brinkman Tara M. , Ehrhardt Matthew J. , Delaney Angela , Srivastava Deo Kumar , Lanctot Jennifer Q. , Armstrong Gregory T. , Robison Leslie L. , Hudson Melissa M. , Ness Kirsten K. , Henderson Tara O.
Published: May 2023

Abstract
Background: Childhood cancer survivors experience reduced physiologic reserve, or frailty, earlier and more frequently than peers. In other populations, frailty is impacted by one’s neighborhood. This study’s purpose was to evaluate associations between neighborhood characteristics and frailty in childhood cancer survivors.
Methods: Participants in the St. Jude Lifetime Cohort Study with geocoded residential addresses were analyzed. Pre-frailty/Frailty was defined as having 1-2/≥3 of sarcopenia, muscle weakness, poor endurance, slow walking speed, and exhaustion from direct assessments. Neighborhood characteristics (e.g., access to exercise opportunities and healthy food, neighborhood socioeconomic status [nSES], and rurality/urbanicity) were determined using publicly available geospatial data. Nested multivariable logistic regression models identified associations between neighborhood characteristics and pre-frailty/frailty, adjusting for chronic health conditions, individual health behaviors and socio-demographics, and high-risk cancer treatment exposures.
Results: For our cohort (N=3806, 46.79% female, 81.40% white, mean age 33.63±9.91 years), compared to non-frail survivors (n=2573;67.6%), pre-frail (n=900;23.6%) and frail survivors (n=333;8.7%) were more likely to live in neighborhoods with decreased exercise opportunities (frail OR:1.62, 1.26-2.09), reduced healthy food access (pre-frail OR:1.28, 1.08-1.51; frail OR:1.36, 1.06-1.75), and lower nSES (pre-frail OR:1.31, 1.12-1.52; frail OR:1.64, 1.30-2.07). Participants had 8% increased odds (95% CI:2-14%) of being pre-frail/frail if they lived in “resource poor” neighborhoods as opposed to “resource rich” neighborhoods after adjusting for other pre-frailty/frailty risk factors.
Conclusions: The neighborhood a childhood cancer survivor resides in as an adult is associated with pre-frailty/frailty.
Impact: This study provides valuable information for creating interventions using neighborhood-level factors to mitigate frailty and improve health outcomes in survivors.
Supplementary Tables S1-S14 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma
Authors: Thiesler Hauke , Gretenkort Lina , Hoffmeister Leonie , Albers Iris , Ohlmeier Luisa , Röckle Iris , Verhagen Andrea , Banan Rouzbeh , Köpcke Nora , Krönke Nicole , Feuerhake Friedrich , Behling Felix , Barrantes-Freer Alonso , Mielke Dorothee , Rohde Veit , Hong Bujung , Varki Ajit , Schwabe Kerstin , Krauss Joachim K. , Stadelmann Christine , Hartmann Christian , Hildebrandt Herbert
Published: May 2023

Supplementary Table S1.Demographic and clinical parameters of GB patient cohorts.Supplementary Table S2.Characteristics of the two cohorts of n = 70 (MHH) and n = 100 (UMG) GB patients stratified for the presence of a functional SIGLEC16 allele (A) or for the occurrence of polySia on tumor cells (B).Supplementary Table S3.Cox proportional hazards regression analysis of covariates for SIGLEC16 and polySia status in relation to OS (MHH and UMG cohorts combined).Supplementary Table S4.Median age of GB cases stratified for SIGLEC16 genotype and polySia on tumor cells.Supplementary Table S5.OS analysis of GB cases receiving (A) or not receiving gross total resection (B) stratified for SIGLEC16 genotype and polySia on tumor cells (MHH and UMG cohorts combined).Supplementary Table S6.OS analysis of GB cases receiving (A) or not receiving chemotherapy (B) stratified for SIGLEC16 genotype and polySia on tumor cells (MHH cohort only).Supplementary Table S7.OS analysis of GB cases receiving gross total resection and chemotherapy stratified for SIGLEC16 genotype and polySia on tumor cells (MHH and UMG cohorts combined, n=101).Supplementary Table S8.OS analysis of IDH-wildtype GB cases (UMG cohort) stratified for SIGLEC16 genotype and polySia on tumor cells.Supplementary Table S9.OS analysis of UMG cohort stratified for MGMT gene promoter methylation and SIGLEC16 genotype, polySia on tumor cells, CD163 and CD74 status.Supplementary Table S10.Characteristics of the two cohorts of n = 70 (MHH) and n = 100 (UMG) GB patients stratified for CD74low and CD74high.Supplementary Table S11. Median age at resection of GB cases stratified for CD163 to CD68 (A) or CD74 to IBA1 ratios (B) alone or in combination with the SIGLEC16 genotype.Supplementary Table S12. OS analysis of GB cases receiving (A) or not receiving gross total resection (B) stratified for CD163 to CD68 or CD74 to IBA1 ratios alone or in combination with the SIGLEC16 genotype (MHH and UMG cohorts combined).Supplementary Table S13. OS analysis of GB cases receiving (A) or not receiving chemotherapy (B) stratified for CD163 to CD68 or CD74 to IBA1 ratios alone or in combination with the SIGLEC16 genotype (MHH cohort only).Supplementary Table S14.OS analysis of GB cases receiving both gross total resection and chemotherapy stratified for CD163 to CD68 or CD74 to IBA1 ratios alone or in combination with the SIGLEC16 genotype (MHH and UMG cohorts combined, n=101).
Table S6 from Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors
Authors: Toker Joseph , Iorgulescu J. Bryan , Ling Alexander L. , Villa Genaro R. , Gadet Josephina A.M.A. , Parida Laxmi , Getz Gad , Wu Catherine J. , Reardon David A. , Chiocca E. Antonio , Mineo Marco
Published: May 2023

Glioblastoma patient characteristics (DFCI)
Supplementary Figure S5 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma
Authors: Thiesler Hauke , Gretenkort Lina , Hoffmeister Leonie , Albers Iris , Ohlmeier Luisa , Röckle Iris , Verhagen Andrea , Banan Rouzbeh , Köpcke Nora , Krönke Nicole , Feuerhake Friedrich , Behling Felix , Barrantes-Freer Alonso , Mielke Dorothee , Rohde Veit , Hong Bujung , Varki Ajit , Schwabe Kerstin , Krauss Joachim K. , Stadelmann Christine , Hartmann Christian , Hildebrandt Herbert
Published: May 2023

OS analysis of the two GB cohorts individually stratified for CD163 to CD68 or CD74 to IBA1 ratios
Supplementary Figure S4 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma
Authors: Thiesler Hauke , Gretenkort Lina , Hoffmeister Leonie , Albers Iris , Ohlmeier Luisa , Röckle Iris , Verhagen Andrea , Banan Rouzbeh , Köpcke Nora , Krönke Nicole , Feuerhake Friedrich , Behling Felix , Barrantes-Freer Alonso , Mielke Dorothee , Rohde Veit , Hong Bujung , Varki Ajit , Schwabe Kerstin , Krauss Joachim K. , Stadelmann Christine , Hartmann Christian , Hildebrandt Herbert
Published: May 2023

PolySia on GB tumor cells is associated with NCAM
Supplementary Figure S2 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma
Authors: Thiesler Hauke , Gretenkort Lina , Hoffmeister Leonie , Albers Iris , Ohlmeier Luisa , Röckle Iris , Verhagen Andrea , Banan Rouzbeh , Köpcke Nora , Krönke Nicole , Feuerhake Friedrich , Behling Felix , Barrantes-Freer Alonso , Mielke Dorothee , Rohde Veit , Hong Bujung , Varki Ajit , Schwabe Kerstin , Krauss Joachim K. , Stadelmann Christine , Hartmann Christian , Hildebrandt Herbert
Published: May 2023

PolySia on CD11c-positive and on CD45-positive, IBA1-negative cells
Table S1 from Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors
Authors: Toker Joseph , Iorgulescu J. Bryan , Ling Alexander L. , Villa Genaro R. , Gadet Josephina A.M.A. , Parida Laxmi , Getz Gad , Wu Catherine J. , Reardon David A. , Chiocca E. Antonio , Mineo Marco
Published: May 2023

Primers used in the study.
Supplementary Fig. 1 from Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors
Authors: Toker Joseph , Iorgulescu J. Bryan , Ling Alexander L. , Villa Genaro R. , Gadet Josephina A.M.A. , Parida Laxmi , Getz Gad , Wu Catherine J. , Reardon David A. , Chiocca E. Antonio , Mineo Marco
Published: May 2023

Supplementary Fig. 1 Analysis of lncRNAs associated with patient response to ICB.
Supplementary Figure 2 from Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation
Authors: Qiao Rui , Wei Mengmeng , Chen Hui , Zhang Xianhong , Zhang Jie , Gao Liyang , Ma Haijun , Wang Yujiong , Li Le
Published: May 2023

S2. TAp73 enhances PPP via 6PGD
Supplementary Figure 1 from Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation
Authors: Qiao Rui , Wei Mengmeng , Chen Hui , Zhang Xianhong , Zhang Jie , Gao Liyang , Ma Haijun , Wang Yujiong , Li Le
Published: May 2023

S1. TAp73 activates the expression of 6PGD
Supplementary Data from MDM2 Inhibition Enhances Immune Checkpoint Inhibitor Efficacy by Increasing IL15 and MHC Class II Production
Authors: Langenbach Marlene , Giesler Sophie , Richtsfeld Stefan , Costa-Pereira Sara , Rindlisbacher Lukas , Wertheimer Tobias , Braun Lukas M. , Andrieux Geoffroy , Duquesne Sandra , Pfeifer Dietmar , Woessner Nadine M. , Menssen Hans D. , Taromi Sanaz , Duyster Justus , Börries Melanie , Brummer Tilman , Blazar Bruce R. , Minguet Susana , Turko Patrick , Levesque Mitchell P. , Becher Burkhard , Zeiser Robert
Published: May 2023

Supplementary Figures Legends and Methods
Supplementary Figure 3 from Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer
Authors: Lin Neng-Yu , Lee Jian-Jr , Chen Syue-Ting , Lin Jung-An , Lin Chia-Hsuan , Lin Hsuan-Yu , Su Yong-Han , Chen Cheng-Chang , Lin Mei-Chun , Kuo Ching-Ying , Huang Min-Chuan
Published: May 2023

Effects of CD44 O-glycans on tumor sphere formation in breast cancer cells.
Supplementary Figure 1 from Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer
Authors: Lin Neng-Yu , Lee Jian-Jr , Chen Syue-Ting , Lin Jung-An , Lin Chia-Hsuan , Lin Hsuan-Yu , Su Yong-Han , Chen Cheng-Chang , Lin Mei-Chun , Kuo Ching-Ying , Huang Min-Chuan
Published: May 2023

C1GALT1 knockdown in breast cancer cells did not cause significant changes in CD44 mRNA levels.
Supplementary Figures from Discovery of Podofilox as a Potent cGAMP–STING Signaling Enhancer with Antitumor Activity
Authors: Han Jing , Hu Shuiqing , Hu Yawei , Xu Yifang , Hou Yanfei , Yang Yinlong , Su Huili , Zhang Zhengyin , Liu Peng , Sun Xuxu , Zhang Conggang
Published: May 2023

Supplementary Figures S1 to S9 with Legends
Table S7 from Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes
Authors: Hay Zachary L.Z. , Knapp Jennifer R. , Magallon Roman E. , O'Connor Brian P. , Slansky Jill E.
Published: May 2023

Intra cluster differential gene expression between Tet-High and Tet-Low cells
Table S6 from Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes
Authors: Hay Zachary L.Z. , Knapp Jennifer R. , Magallon Roman E. , O'Connor Brian P. , Slansky Jill E.
Published: May 2023

Differential gene expression between Tet-Positive or Tet-Negative clusters
Supplementary Table 4 from Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes
Authors: Hay Zachary L.Z. , Knapp Jennifer R. , Magallon Roman E. , O'Connor Brian P. , Slansky Jill E.
Published: May 2023

Cluster ID Table
Supplementary Data Table1 from Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma
Authors: Yeo Alan T. , Shah Rushil , Aliazis Konstantinos , Pal Rinku , Xu Tuoye , Zhang Piyan , Rawal Shruti , Rose Christopher M. , Varn Frederick S. , Appleman Vicky A. , Yoon Joon , Varma Hemant , Gygi Steven P. , Verhaak Roel G.W. , Boussiotis Vassiliki A. , Charest Al
Published: May 2023

Supplementary Table 1