bluuebunny/crossref_metadata_2025 huggingface dataset:
BICOMPLEX ANALYSIS OF INVARIENT POWER SUPPLY SYSTEMS BASED ON RENEWABLE ENERGY SOURCES
Authors: Belenok N.V. , Chibelis V.I. , Spinul L.Yu
Published: July 2022

The article considers a bicomplex calculation for calculating the invariant power supply systems based on renewable energy sources. Modern energy supply systems based on renewable energy sources have non-linear systems with complex transients and possible critical and chaotic regimes. The study of structures of hypernumerical systems, their features, methods of calculation and approximation of the elementary functions of a hypercomplex variable allows to effectively apply such systems in mathematical modelling of invariant power supply systems based on renewable energy sources. In some cases, the use of hypernumerical systems makes it possible to replace the original problem with an equivalent one, that is to build a bicomplex solution model.

The system of complex numbers was considered as the initial system. With recurrent doubling of the system, hypernumerical systems of different dimensions with different properties were obtained, which made it possible to assign different values to the products of imaginary units. It is proved that the introduction of additional conditions of commutativity and associativity, which apply to real numbers and imaginary units, allows to specify the choice of a hypernumerical system.

In the analysis of nonstationary processes of invariant systems and the study of the possibilities of hypernumerical systems, the expediency of choosing a bicomplex calculation method in mathematical modelling of systems with multiple modulation is substantiated. The method of bicomplex representation involves direct and inverse bicomplex transformation, which allows obtaining an analytically complete solution for the analysis of an invariant power supply system based on renewable energy sources. Examples of the use of bicomplex integral transformation for the analysis of systems with multiple modulation are considered. The application of the hypercomplex calculus apparatus for the transformation of systems of differential equations is proposed to simplify or compress them into one equation. It is shown that the use of hypercomplex calculus allows to significantly reduce the amount of processed information without reducing the informativeness of the mathematical model.

The proposed formulation of tasks in a hypercomplex view allowed to compress the processing information and obtain a compact vortex for the output signal.
ASSESSMENT OF RISK FOR THE INTEGRATION OF RENEWABLE ENERGY SOURCES INTO THE ELECTRICITY SUPPLY SYSTEM
Authors: Stepanenko V. , Zamulko A , Veremiichuk Y. , Nakhodov V.
Published: July 2022

The work is devoted to the development of a methodology that allows combining qualitative and quantitative assessments of different risk factors to make an integrated decision when renewable energy sources connect to the electricity supply system. The integration of quantitative information and qualitatively presented knowledge through the creation of appropriate algorithms can significantly expand the possibilities of risk analysis of renewable energy sources, established energy systems and justification of measures to manage them.

The key features of large-scale and complex systems are the diversity and interdependence of the elements included in them, the large number of decision-makers in conditions of high uncertainty and the uniqueness of these objects. Therefore, the study describes the methods and approaches that can be used to analyze the risks of complex systems. In conditions of high uncertainty and complexity of large-scale systems, many solutions can be obtained by using qualitative assessments based on the knowledge and experience of experts.

Maintaining the reliability, stability and efficiency of the electrical system is becoming a difficult issue for distribution networks with variable energy resources. Further movement in the direction of increasing the share of solar power plants (SPP) in the generation of the power system is a great challenge for effective management of the distribution network and a serious threat to its normal functioning.

The article identifies the main factors that lead to the problems of integration of SPP. Also, the probability of occurrence and the level of possible consequences of the implementation of each of the identified risk factors were assessed by using the method of expert assessments.

According to the results of the study, the main problems in integrating SPP into the power supply system are increasing shunting power, deteriorating electricity quality, the need to modernize lines, increasing debt on the "green" tariff, higher harmonics and reactive power flow.
STATE AND PROSPECTS OF DEVELOPMENT OF LOCAL ENERGY OBJECTS WITHIN MICROGRIDS
Authors: Khotian A. , Rozen V.
Published: July 2022

Goal. Clarify the definition of the term "local energy object", by disclosing its essence and content in the energy network. To find out the strategic directions necessary for the development and dissemination of energy innovations in Ukraine with the participation of microgrids.

Task. Analyze and establish requirements for determining the term of a local energy object, develop a classification of energy objects according to different classification criteria. Justify the importance and essence of local energy objects in the power grid. Conduct a comprehensive assessment and analysis of the advantages and disadvantages of microgrids through the use of SWOT - analysis methodologies.

The result of the study. The article proposes and formulates the definition of the term of the local energy object. The classification of objects is developed by such categorical features as: economic - geographical position, functional purpose, power supply mode, criterion of effective management, method of management, type of performed task, parameter of electric energy consumption (power, type of current), size of object, human influence, form of ownership, category of electric receivers. The advantages and disadvantages, as well as opportunities and threats to the development of power supply of local objects as part of microgrids are presented. SWOT analysis methodology was used to conduct analytical research (analysis).

Scientific novelty consists in the introduction into scientific circulation of a new term, such as "local energy object", as well as in the disclosure of its essence, content and meaning.

Conclusions and practical significance. The definition of the term "local energy object" is clarified, its essence, content and meaning in the composition of energy networks are revealed, which helps to characterize the main subjects of energy. The strategic directions necessary for the development and dissemination of energy innovations in Ukraine in the long run are provided.
COMPARATIVE ANALYSIS OF TECHNOLOGIES OF JET FUEL PRODUCTION FROM ALCOHOLS
Authors: Boichenko S. , Yakovlieva A. , Bodnar D. , Hudz A. , Moskovchuk M. , Loriia M.
Published: July 2022

The article considers the question of competitive ability of technologies of alternative aviation fuels production and its application in modern transport sector that develops quickly. Modern tendencies in transport sphere concerning the necessity of transition from conventional oil-derived fuel to alternative one for both road and air transport are considered in the article. These tendencies are explained by the limitation of crude oil deposits, from one side and worsening of the state of environment caused by exhaust gases emissions from another side. Moreover, international aviation authorities, such ICAO, IATA determine the necessity of active development and implementation of alternative aviation fuels. The article analyzes variety of available today renewable feedstock and technological processes of its processing, which are used today for production of alternative aviation fuels. Peculiarities of direct ethanol use in blends with motor fuels are shown and necessity of its chemical conversion for use in jet fuels is substantiated. The comparative analysis of characteristics of technological processes of alternative jet fuels production based on biomass was done. Processes of alcohols (ethanol, n-butanol and iso-butanol) production from renewable plant feedstock and processes of its further conversion to alternative jet fuel are considered. Two methods of ethanol production (petrochemical and biochemical) were shown and analyzed; advantages and disadvantages of both methods were presented.

It was shown that today application of alternative aviation fuels produced from alcohols is allowed in blends with conventional oil-derived jet fuels in quantity up to 50 %.
FORMATION OF A STRATEGY FOR INCREASING THE ENERGY EFFICIENCY OF METALLURGICAL ENTERPRISES AS GUARANTEE OF DECARBONIZATION OF THE UKRAINIAN ECONOMY
Authors: Nakhodov V. , Borychenko O. , Cherniavskyi A.
Published: July 2022

The metallurgical industry of Ukraine in wartime faced significant difficulties in its functioning. However, at the moment there is a gradual recovery of the industry. It should be noted that steel production is an extremely energy-intensive process, accounting for the second largest share of energy consumption and the largest share of CO2 emissions. Therefore, in order to control the growth of energy consumption and CO2 emissions in this industry, as well as to be competitive in the international market, Ukrainian metallurgical enterprises should not only expect maximum assistance from the government bodies and international partners in matters of logistics and sales markets, but also focus on energy efficiency issues and decarbonization of their production. While improving the energy efficiency of steel production through the introduction of standard energy efficiency measures will help the industry, there is a need to further develop and deploy a wide portfolio of breakthrough solutions to improve processes and infrastructure. This will achieve long-term deep reductions in CO2 emissions. For this activity to be purposeful rather than chaotic, individual enterprises and the industry must develop a strategy to increase energy efficiency and decarbonize their production. This article is devoted to one of the possible approaches to solving this issue. Along with a description of the mathematical model for the formation of an optimal strategy for improving energy efficiency and decarbonization of metallurgical industries, the article presents the structure of energy costs, as well as the list of significant energy usages at metallurgical enterprises. In addition, a separate place in the article is given to the issue of building an energy baseline, taking into account the provisions of modern international standards in the field of energy management system (ISO 50001, ISO 50006, ISO 50047), as well as the main factors affecting energy consumption. The paper also presents the list of typical measures for improving the energy efficiency of metallurgical enterprises for each group of significant energy usages.
DRONE POSITIONING SYSTEMS THAT USE DIGITAL CAMERAS
Authors: Averin Dmytro , Borovytsky Volodymyr , Mykytenko Volodymyr
Published: July 2022

Unmanned aerial vehicles are very important in everyday life. Their number is increasing every day, as well as the scope of their use. Therefore, it becomes necessary to automate their flight from departure to kindergarten. During automatic flight, drones have certain problems during takeoff, landing and positioning. The problem is that when landing and taking off, it is necessary to ensure high positioning accuracy, which is impossible when using GPS, as it can provide accuracy of only a few meters, which is not enough, and the use of operators is accurate, but this method requires the use of quality cameras with stabilization. These stabilization cameras are very heavy, so the payload of drones is reduced, and they are very expensive (usually more expensive than the drone itself). Also, the use of operators during landing and departure can lead to a catastrophe due to human factors. The task of this article is to create a classification table, analyze landing methods, assess their advantages and disadvantages, give recommendations for the use of the most effective positioning system, as well as the development of new positioning methods.

In the course of work modern, and also the most widespread methods of positioning were considered, the critical analysis of robots is made. As a result, it was proposed to classify drone positioning systems that provide reliable takeoff, landing and delivery of goods using digital cameras. This classification includes all combinations of digital cameras and radiation sources that can be located both on the drone and on the landing or cargo delivery area. Examples are given for each combination proposed in the classification. A thorough analysis of the advantages and disadvantages of each configuration of digital cameras and radiation sources is given. Recommendations for choosing the best drone positioning system are provided. The main disadvantages of these systems are the complexity of algorithms, which makes systems more expensive, as well as complicates the creation of the system, which does not preclude the possibility of making a mistake when creating a system. And this can lead to an accident. All DPSs can be classified on group depending on the number of digital cameras, number and shape of reference light sources, locations of digital cameras and location of the light sources. From the point of reliability and economy the best DPS should include one camera on a drone and a minimal set of reference light sources on the ground. The authors suppose that three reference light sources that specify a triangle is the best choice because it makes possible estimation of the distance and angular coordinates of the landing pad.
APPLICATION OF THREE-WAVE HETERODINE INTERFEROMETRY FOR NANORIZED LAYERS THICKNESS MEASUREMENT IN THE PROCESS OF THEIR DEPOSITION
Authors: Lendiel Vasyl , Stepakhno Iryna , Yarovoi Leonid
Published: July 2022

The paper proposes a new method of current measurement of the layer thickness of optical films in the process of their forming, in particular, by the method of vacuum deposition. Such films, among other things, are used to create a variety of optoelectronic devices and optical nanosensors for laboratory research in the chemical and pharmaceutical industries, for environmental monitoring.

We propose a method for measuring the phase of a laser beam, which is based on heterodyne interferometry. The method of heterodyne interferometry in comparison with ordinary interference methods provides better S/N ration results due to the transfer of the investigated signal from the low frequency domain to heterodyne frequency. Our proposed approach is the three-wave heterodyne interferometry (TGI), otherwise - TWI (three waves interference). The TGI method is designed to critically increase the sensitivity to small amplitudes of laser Doppler vibrometers and increase their noise resistance. In interference gauges of optical film thickness, in refractometers, and in many other film thickness gauges as well as in laser Doppler vibrometers the investigated parameter is the phase shift of probing optical radiation. Therefore, the developments of TGI in laser Doppler vibrometers can be used to measure the phase shift.

The analysis of the new method on mathematical model of TGI was provided. We have got the relations of the output signal of a three-wave heterodyne interferometer dependence on the phase shift , as well as on the thickness of optical films and on their refractive index. The simulation results show that for the optoelectronic equipment that provides with an error of up to 10 %, the absolute error of phase shift measurement, compared to the classical heterodyne interferometer, can be reduced to 103 times. The same results applies to the thickness of the optical coating layer.

The paper also analyzes the results of experiments on the use of TGI in laser vibrometers and shows that they indicate the possibility of measuring the phase  of optical radiation up to 10-5. The disadvantage of the proposed method is its non-linearity and, as a result, a limited linear range. Ways of extending the linear range are discussed.
In-vitro Study of Chemical Composition, Antimicrobial and Antioxidant Properties of Adiantum capillus-veneris L. Essential Oil
Authors: Nasrollahi Iman , Talebi Ebrahim , Bashardoost Zahra
Published: July 2022

Background: The use of medicinal plants and their effective compounds as natural sources that have antioxidant properties, has been considered by researchers. Antioxidants are compounds that effectively inhibit the reaction of oxygen and nitrogen-free radicals with biomolecules in a variety of ways, reducing damage or preventing cell death, cardiovascular diseases, and cancers. Objective: In this study, chemical compounds of Adiantum capillus-veneris essential oil were used to evaluate its antioxidant and antimicrobial activity using water distillation and gas chromatography. Methods: The whole plant was dried at room temperature at 25 ° C and the distillation method with water with modifications was used using a Clevenger device for essential oil extraction. Gas chromatography-mass spectrometry (GC/MS) was used to identify the resulting essential oil compounds and the antioxidant and antibacterial activity of the essential oil was evaluated. Results: The most important chemical constituents of Adiantum capillus-veneris essential oil were carvone (33.00%), carvacrol (15.05%), hexadecanoic acid (7.02%), hexahydrofarnesyl acetone (4.25%) and n-nonanal (4.2%). The antibacterial activity of Adiantum capillus-veneris essential oils (mg/ml) was calculated and the highest antibacterial activity was determined by Staphylococcus aureus (8.23±1.07), Streptococcus pyogenes (12.46±1.62), and Diphtheroid (11.37±1.36) at a concentration of 100 mg/ml of essential oils. Conclusion: The results of the present study showed that the essential oil of Adiantum capillus-veneris prevented the growth of three pathogenic bacteria. This antibacterial property is due to the presence of flavonoid compounds in Adiantum capillus-veneris has the capacity for therapeutic and medical uses.
Источники турбулентности на прямом крыле сверхзвукового пассажирского самолeта
Authors: Чувахов Павел Владимирович , Chuvakhov Pavel Vladimirovich , Погорелов Илья Олегович , Pogorelov Il'ya Olegovich
Published: July 2022

В рамках полных уравнений Навье-Стокса рассмотрены два наиболее вероятных источника возмущений, которые способны приводить к турбулизации пограничного слоя на гладком прямом крыле сверхзвукового пассажирского самолeта: атмосферная турбулентность и акустический шум от турбулентного пограничного слоя на фюзеляже. Проанализированы частотно-волновые характеристики возмущений, развивающихся в пограничном слое на крыле; выявлен основной механизм перехода к турбулентности. Результаты расчeтов сопоставлены с результатами линейной теории устойчивости.
Многокритериальная интервальная оптимизация химических реакций на основе кинетической модели
Authors: Коледина Камила Феликсовна , Koledina Kamila Feliksovna
Published: July 2022

В работе сформулирована задача многокритериальной интервальной оптимизации условий проведения сложных химических реакций на основе интервальной кинетической модели. На основе алгоритмов эволюционной оптимизации предложен метод решения в виде интервального фронта Парето. Для реакции диметилкарбоната со спиртами в присутствии металлокомплексного катализатора Со$_2$(СО)$_8$ разработана интервальная кинетическая модель, определены двусторонние ограничения концентраций компонент и кинетические параметры. Для данного процесса рассчитано влияние температуры и ее возможного возмущения на значения критериев оптимальности: выход целевого продукта и производительность с соответствующими ограничениями по изменению ширины интервала.
Determination of the input filter parameters of the active rectifier with a fixed modulation frequency
Authors: Krylov D. S. , Kholod O. I.
Published: July 2022

Goal. Development of a methodology for calculating the parameters of the active rectifier-voltage source input filter operating with a fixed modulation frequency to ensure electromagnetic compatibility with the supply network acceptable by standards at minimum values of the input inductance and checking its main characteristics on a mathematical model. Methodology. The authors have developed a methodology for calculating the parameters of the input filter of an active rectifier-voltage source. The calculation results are verified on the constructed mathematical model of a frequency converter, the scheme of which is an active rectifier and an autonomous voltage inverter. A series of experiments was carried out on a mathematical model to study the dependence of the total harmonic distortion of current and mains voltage on the value of the input inductance for various parameters of the input filter. Results. The structure and calculation procedure the input filter of an active rectifier operating with a fixed modulation frequency are proposed. The simulation results showed that the inclusion of a filter at the input of the active rectifier significantly improves its electromagnetic compatibility with the supply network in the entire range of variation of the input inductance of the circuit and makes it possible to achieve the values of the total harmonic distortion permissible by the norms. Originality. A structure and a calculation procedure the input filter of an active rectifier-voltage source operating with a fixed modulation frequency are proposed. Practical significance. The dependencies obtained in the article allow us to evaluate the relationship between the parameters of the filter elements and its characteristics among themselves and come to a compromise between them when designing a scheme for specific technical conditions.
A comparative study of maximum power point tracking techniques for a photovoltaic grid-connected system
Authors: Louarem S. , Kebbab F. Z. , Salhi H. , Nouri H.
Published: July 2022

Purpose. In recent years, the photovoltaic systems (PV) become popular due to several advantages among the renewable energy. Tracking maximum power point in PV systems is an important task and represents a challenging issue to increase their efficiency. Many different maximum power point tracking (MPPT) control methods have been proposed to adjust the peak power output and improve the generating efficiency of the PV system connected to the grid. Methods. This paper presents a Beta technique based MPPT controller to effectively track maximum power under all weather conditions. The effectiveness of this algorithm based MPPT is supplemented by a comparative study with incremental conductance (INC), particle swarm optimization (PSO), and fuzzy logic control (FLC). Results Faster MPPT, lower computational burden, and higher efficiency are the key contributions of the Beta based MPPT technique than the other three techniques.
Multi-objective optimal power flow based gray wolf optimization method
Authors: Mezhoud N. , Ayachi B. , Amarouayache M.
Published: July 2022

Introduction. One of predominant problems in energy systems is the economic operation of electric energy generating systems. In this paper, one a new evolutionary optimization approach, based on the behavior of meta-heuristic called grey wolf optimization is applied to solve the single and multi-objective optimal power flow and emission index problems. Problem. The optimal power flow are non-linear and non-convex very constrained optimization problems. Goal is to minimize an objective function necessary for a best balance between the energy production and its consumption, which is presented as a nonlinear function, taking into account of the equality and inequality constraints. Methodology. The grey wolf optimization algorithm is a nature inspired comprehensive optimization method, used to determine the optimal values of the continuous and discrete control variables. Practical value. The effectiveness and robustness of the proposed method have been examined and tested on the standard IEEE 30-bus test system with multi-objective optimization problem. The results of proposed method have been compared and validated with hose known references published recently. Originality. The results are promising and show the effectiveness and robustness of proposed approach.
System analysis of information and analytical support of administrative management
Authors: Trysnyuk Vasyl , Trysnyuk Taras , Kurilo Anatolii , Holovan Yurii , Pashchenko Yevhen
Published: July 2022

Relevance. The work is devoted to solving a topical scientific and applied problem in the field of information technology - analysis of information and analytical support systems in the field of administrative management, taking into account the requirements of complexity, support management decisions based on knowledge-oriented tools, and integration of information and analytical support systems. interoperability. Results. Conceptual structures of the governing body and ASIAS are constructed, the model of information-analytical activity in the governing body is offered, ASIAS is structured with allocation of their basic structural elements. The unified architecture of ASIAS is offered, the structure of the necessary components of ASIAS realizing processes of collecting and transformation of the information (documents) is defined. The scientific results of research are the basis of a new theory of situational regulation of technological processes in the governing body in the automated processing of information flows, the application of the concept of "executive obligation" with the implementation of appropriate policies, theory of information document flow processing as a component of tele-traffic theory, models of research of specificity of information load of ASIAS in stationary mode, intensity of processing of document flows and interaction of processing processes, solving the problem of structuring knowledge based on the methodology of growing pyramidal networks, based on the theory of logical-linguistic information models, and ontological descriptions of information. Based on these paradigms the possibility of construction of ASIAS as complex corporate systems on the basis of the tested decisions is defined. Thus, components of the general methodology of use of information technologies should be the factors received as a result of researches of the given work.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 09.07.2022 г. по 15.07.2022 г.
Authors: Чумачкова Елена , Краснов Ярослав , Дмитриева Людмила , Осина Наталия , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: July 2022

В обзоре представлена информация по актуальным геновариантам вируса SARS-COV-2, циркулирующим в настоящее время, геномные последовательности которых размещены в международной базе данных GISAID за неделю с 09.07.2022 г. по 15.07.2022 г.
Rupture Behavior of the Litang Fault within the Sichuan-Yunnan Active Block, Southeastern Tibetan Plateau
Authors: Gao Shuaipo , Chen Lichun , Li Yanbao , Wang Hu , Han Mingming , Feng Jiahui , Lu Lili , Peng Sanxi , Jin Chao , Liu Langtao
Published: July 2022

In mainland China, approximately 86% of M≥7 earthquakes have occurred in the block boundary zone, which has been well explained by active block theory. However, a few large earthquakes have occurred within the active block, which provides us with an opportunity to better study the deformation of the Tibetan Plateau. The Litang Fault (LTF) is a strike-slip fault within the Sichuan-Yunnan Active Block and produced the 1948 Litang M7.3 earthquake. We presented the Holocene rupture behavior of the LTF based on detailed field investigations, paleoearthquake trenching, and radiocarbon dating. Specifically, we revealed 13 Holocene paleoearthquake events at four trenching sites and divided these events into 3 rupture cycles at the whole-fault scale. The seismic rupture behavior of the LTF is characterized by recurrent southeastward migration, and since the Holocene, the period of each rupture cycle has decreased rapidly from 8000 years to 500 years. Our results may provide geologic evidence for understanding the intrablock stress patterns and material transfer of the southeastern region of the Tibetan Plateau. The rapidly enhanced fault activity of the LTF since the late Holocene indicates that the LTF may have played an important role in accommodating the deformation of the southeastern region of the Tibetan Plateau.
Plan de negocio de la creación de una empresa especializada en asesoría en costos para las empresas MYPES del distrito de Ate
Authors:   , Pinto Miranda Evelyn Beatriz , Martinez Sanchez Maria Teresa , Valdivieso Aguirre Janeth , Guzman Villanueva Josue Enrique , Jara Peralta Daniel
Published: July 2022

En el presente trabajo se elaboró un plan de negocio, que está centrado a la reducción de costos de las empresas que estén situadas en el distrito de Ate. El proyecto trata de crear una entidad que se encargará a brindar asesoría especializada en costos para las empresas MYPES de Ate, que tendrá como nombre “COSTOS SOLUTIONS SAC”. Nuestra propuesta de valor es brindar asesoría especializada en costos, a través de los medios más adecuados como presencial, virtual y vía telefónica, haciendo seguimiento constante. Analizando el sector de Ate se identificó que nuestros posibles competidores son el estudio contable Romaní y el estudio contable J & C SAC que también se encuentran ubicados en el distrito de Ate. Para el estudio cualitativo se efectuó 6 entrevistas a fondo dirigidas especialmente a los empresarios y emprendedores de Ate que tienen a su cargo y responsabilidad del crecimiento de su empresa MYPE. Y en el análisis cuantitativo se realizaron 68 encuestas dirigidas a las personas con negocio, pudiendo identificar la necesidad del cliente y la importancia de una asesoría especializada en costos para las empresas de Ate. En el análisis de mercado se identificó que nuestro mercado objetivo será un 5% del total de las empresas de Ate, a un crecimiento anual de 1.7% proyectada a 5 años con un crecimiento promedio. Se consideró a 83 empresas como nuestros principales consumidores en el distrito de Ate. En la ingeniería del proyecto se definió como un punto de vista clave para la asesoría especializada en costos, que va tener como origen en un local en el distrito de Ate, justamente en el local comercial Plaza Vitarte, ya que a los alrededores existen mercados y centros comerciales, misma donde se encuentran los empresarios…
Centro de capacitación agrícola comunitario: relación entre la calidad de los espacios físicos educacionales y los valores comunitarios en el Centro Poblado Rural Quebrada Verde, Pachacamac, Lima, 2020
Authors:   , Vasquez Santos Maryori Dayana
Published: July 2022

Esta tesis reúne parámetros y características que contribuyen al diseño de espacios educativos de calidad, siendo estos fortuitos para el desarrollo de una relación cercana de los usuarios con su entorno físico (natura o artificial). Se tomó como objeto de análisis de esta investigación a la Institución Educativa Santa María Reyna ubicada en el CPR de Quebrada Verde en el distrito de Pachacamac en Lima, Perú. La recolección de información se realizó mediante una guía de observación y entrevistas semiestructuradas a dirigentes de distintos grupos sociales del centro poblado; evaluando en ambos casos el nivel de relación de la población con su entorno natural, desde las aulas de clase hasta las reuniones vecinales; determinando el creciente interés de la población por recuperar los valores ambientales que se han perdido por el paso del tiempo, y carencia de formación y orientación por la escasez de una infraestructura educacional que potencie dichas variables. El aporte teórico de esta investigación es exponer variables sociales, económicas y sobre todo ambientales que contribuyen a la mejora del desarrollo local de la comunidad rural de Quebrada Verde, todas ellas, motivadas por la riqueza de recursos naturales que se encuentran en su territorio, determinando una propuesta arquitectónica con espacios de calidad que prospera la relación de la población con su entorno natural cercano, a través del diseño adecuado de espacios educativos en contacto con la naturaleza y el especial cuidado de las especies cultivadas para mejora de la calidad ambiental del proyecto, la investigación se justifica en el ámbito práctico desarrollando parámetros y referencias para lograr un diseño práctico y funcional de espacios formativos y educacionales, mejorando las relaciones comunitarias con su ambiente natural a partir de la calidad de su Arquitectura Educacional.
La gestión de tesorería y la rentabilidad en una empresa dedicada a la fabricación de mobiliario médico, año 2020
Authors:   , Nolasco Urbano Cinthia Gissel
Published: July 2022

Esta investigación tiene como objetivo determinar si existe una relación entre la gestión de tesorería y la rentabilidad en una empresa dedicada a la fabricación de mobiliario médico en el año 2020. La metodología elegida es no experimental con un enfoque cuantitativo y de diseño correlacional. La hipótesis plantea que la gestión de tesorería se relaciona directamente con la rentabilidad de la empresa. Los resultados se obtienen a través de encuestas procesadas por el programa estadístico SPSS y respaldan la hipótesis alternativa. Esto permite concluir que existe una correlación significativa entre la gestión de tesorería y la rentabilidad demostrado por un coeficiente de correlación de Pearson de 0.886 que indica que la correlación es positiva fuerte.
Establishing a near-surface geophysical testing laboratory For Visualizing Subsoil Structure Using Geo-electrical methods
Authors: Aziz Akram
Published: July 2022

Near-surface geophysics uses the investigational methods of geophysics to study the nature of the outermost part of the earth’s crust. Man interacts with this part of the earth’s crust: he walks on it; he drills and excavates into it; he constructs structures on and in it; he utilizes its water and mineral resources, and his wastes are stored on and in it and seep into it.Near-surface geophysics investigations include numerous and varied application areas and both basic and applied research in support of those applications (National Research Council, 2000). These application areas are characterized by various descriptors, e.g., engineering, geotechnical, environmental, groundwater, mining, archaeological, and forensic. Some typical examples of these application areas are Engineering and geotechnical geophysics, Environmental, Groundwater exploration, Mining, Archaeological prospecting, and Forensic research.The near-surface geophysics application areas listed above are characterized and distinguished by their shallow depths of investigation or interest requirements for high resolution, both vertically and horizontally. The near-surface geophysics application requires extensive laboratory execution, which may help in planning fieldwork and instrumental testing. Lastly, confirmation, verification, or validation of filed results are needed for interpretation and presentation that are subject to public health and safety concerns and constrained by legal and regulatory considerations.The aim of our research is to establish a testing lab for experimental geophysical measurements. Geophysical laboratory measurements provide information on the physical properties of bedrock and soil. These measurements and tests are vital for geophysical interpretation and modeling. The lab can also be used to demonstrate various near-surface geophysical applications to geology students, and provide a good simulation environment for various geophysical applications, which has been mentioned in the previous section. In this work, we will focus on how establishing a testing lab for resistivity measurements.
The non-native plant invader in the beech forest does not make nematode communities less structural
Authors: Renčo Marek , Jurová Jana , Čerevková Andrea
Published: July 2022

Invasive plants are capable of homogenizing the above and belowground biota and are together with climate change recognized as one of the biggest threats to global biodiversity. Soil nematode communities reflect the surroundings they inhabit and they are used as biological indicators of soil condition. In this study, we evaluated soil properties and nematode communities in the beech forest floor covered by dense vegetation of invasive Impatiens parviflora (small balsam) and compared them with uninvaded sites. We assumed that the invasion of I. parviflora could be influencing soil fauna through their litter and also could be changing several soil properties which consequently affect soil nematode communities. A total of 52 nematode species were found in the soil samples. The mean number of species varied from 18 to 31, but did not significantly differ between invaded and uninvaded plots across all sampling dates. Nevertheless, redundancy analysis indicated that the nematode community in plots with small balsam differed significantly from that in uninvaded plots, reflecting different proportions of genera in the two communities. Small balsam invasion significantly enhanced the relative abundance of bacterivores whereas the decreased abundance of plant parasites and root-fungal feeders, mainly in spring and summer sampling dates. Ordination of nematode species along the structure index and enrichment index trajectories revealed maturing food web, low to moderately disturbed in the I. parviflora invaded soils as well as uninvaded forest plots. Decomposition channels of soil food webs in both plots were balanced, fungal-bacterial mediated, nonetheless low values of channel index suggesting prevailing bacterial decomposition. Our study reveals, that expansion of I. parviflora moderates influenced composition of nematode communities, and the soil food web, increased soil nitrogen, carbon and C/N ratio, whereas did not modify soil acidity.
Preoperative circulating tumor DNA level is associated to poor overall survival in patients with ovarian cancer
Authors: Dobilas Arturas , Chen Yilun , Alcaide Miguel , Brueffer Christian , Leandersson Pia , Saal Lao H , Borgfeldt Christer
Published: July 2022

Background
Circulating tumor DNA (ctDNA), which is shed from tumor cells into the blood, is a promising minimal-invasive method for cancer diagnostics and monitoring. The aim of this study was to evaluate preoperative ctDNA levels in the plasma of patients with ovarian cancer and correlate the levels to clinicopathological parameters and patient outcome.
Methods
Tumor DNA was extracted from ovarian tumor tissue from 41 patients. Targeted sequencing using a panel of 127 genes recurrently mutated in cancer was performed to identify candidate somatic mutations in the tumor DNA. SAGAsafe digital PCR (dPCR) assays targeting the candidate mutations were used to measure ctDNA levels in patient plasma samples, obtained prior to surgery, to evaluate ctDNA levels in terms of mutant copy number/mL and variant allele frequency.
Results
Somatic mutations were found in 24 tumors, of which seven were from patients with borderline, and 17 with invasive cancer diagnosis. TP53 was the most frequently mutated gene. Fifteen of 24 patients had detectable ctDNA levels in pre-operative plasma. Plasma ctDNA mutant concentration increased with higher stage (ptrend <0.001). Cancer patients with more than 10 ctDNA mutant copies/mL in plasma prior to surgery had significantly worse overall survival (p = 0.008).
Conclusions
Measuring ctDNA in pre-operative plasma may be useful as a predictive biomarker for tumor staging and prognosis in ovarian cancer patients.
Crosslinked ion diffusion inhibitors stabilize 3D/2D perovskite heterostructures for efficient and stable photovoltaics
Authors: Luo Long , Zeng Haipeng , Wang Zaiwei , Li Min , You Shuai , Chen Bin , Maxwell Aidan , Wang Chao , Li Shangzhi , Cai Xueqing , Li Weixi , Li Lin , Guo Rui , Huang Rong , Liang Wenxi , Rong Yaoguang , Sargent Edward , Li Xiong
Published: July 2022

Two-dimensional (2D) and quasi-2D modifications of 3D perovskite active layers have contributed to advances in the performance of perovskite solar cells (PSCs); however, the ionic diffusion between the surface 2D and bulk 3D perovskites leads to the degradation of the 2D/3D perovskite heterostructure and limits the long-term stability of PSCs. Here we incorporate a crosslinked ion diffusion inhibitor (CDI) on the top of a 3D perovskite layer, and then deposit a 2D perovskite layer via a vapor-assisted two-step process to form a 3D/CDI/2D perovskite heterostructure. Photoluminescence spectra and thickness-profiled elemental analysis indicate that it is by inhibiting ion diffusion between the 2D and 3D perovskites that the CDI stabilizes the heterostructures. Based on carbon electrodes, we report small-area devices with an efficiency of 21.17%, and mini-modules with an efficiency of 19.56%. After 4,390-hours operation under maximum power point tracking and one-sun illumination at elevated temperature, devices retain 90% of initial performance.
Rotational symmetry and rotating waves in planar integro-difference equations
Authors: LeBlanc Victor G.
Published: July 2022

Mathematical models often possess symmetries, either because of actual symmetries of the situation being modelled, or as approximations. It is well-known that these symmetries often impose restrictions on the solutions to these models. In this paper, we investigate the role of rotational symmetry in certain integro-difference equations, and study the existence of rotating wave solutions to these equations. We perform explicit computations in the case where the integration kernel is a Gaussian distribution, which often occurs in applications.
Patients with STAT1 gain-of-function mutations display increased IFNα-induced T cell apoptosis and upregulation of interferon signature that are responsive to ruxolitinib treatment.
Authors: Dotta Laura , Todaro Francesca , Giacomelli Mauro , Pinelli Marinella , Cortesi Manuela , Moratto Daniele , Ferraro Rosalba , Giliani Silvia , Badolato Raffaele
Published: July 2022

Introduction. The signal transducer and activator of transcription (STAT1) gain of function (GOF) syndrome accounts for most cases of chronic mucocutaneous candidiasis but is characterized by a broader clinical phenotype that may include bacterial, viral, or fungal infections, autoimmunity, autoinflammatory manifestations, vascular complications, or malignancies. The spectrum of immunological abnormalities may vary and influence the infectious morbidity.
Methods. We investigated the mechanisms that may determine T lymphopenia in STAT1-GOF patients and evaluate the interferon signature in patients exhibiting autoimmunity.
Results. STAT1-GOF patients may manifest T lymphopenia particularly by adult age. We observed how the hyperactivation of STAT1 associated with a disrupted pattern of apoptosis as the stimulation with IFNα increased the expression of markers of apoptosis via caspase activation and significantly increased the apoptosis of T cells in STAT1-GOF patients. The use of a JAK inhibitor, ruxolitinib, was effective in controlling the hyperphosphorylation of STAT1 and reducing T cells apoptosis. This effect was translated in vivo to the increase of lymphocyte count in two treated adult patients. Similarly, ruxolitinib modulated the activation of interferon signature following IFNα stimulation, that may correlate with autoimmune complications.
Conclusion. In STAT1-GOF patients, the hyperactivation of IFNα-mediated response may contribute to T lymphopenia throughout increased cellular apoptosis and determine immunedysregulation manifestations. Our results support the use of JAK inhibitor to revert the pathogenesis of T lymphopenia thus reducing the risk of life-threatening infections and suggest the evaluation of interferon score in STAT1-GOF patients as a marker to monitor the risk of autoimmune manifestations.
Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis
Authors: Zhang Chunzhi , Zhou Yuan , Gao Ya , Zhu Ze , Zeng Xiangliang , Liang Weizi , Sun Songwei , Chen Xiuli , Wang Hu
Published: July 2022

Background
Radiotherapy is the primary therapeutic option for glioblastoma. Some studies proved that radiotherapy increased the release of exosomes from cells. The mechanism by which these exosomes modify the phenotype of microglia in the tumor microenvironment to further determine the fate of irradiated glioblastoma cells remains to be elucidated.
Methods
We erected the co-culture system of glioblastoma cells and microglia. After radiation, we analyzing the immunophenotype of microglia and the proliferation of glioblastoma. By whole transcriptome sequencing, we analyzed of circRNAs in exosomes from glioblastoma cells and HMC3 cells. We used some methods, which included RT-PCR, dual-luciferase reporter, et al., to identify how circ_0012381 from radiated glioblastoma cell-derived exosomes regulated the immunophenotype of microglia to further affect the proliferation of glioblastoma.
Results
Radiated glioblastoma cell-derived exosomes markedly induced M2 polarization in microglia. These M2-polarized microglia promoted the proliferation of irradiated glioblastoma cells. Circ_0012381 expression was increased in the irradiated glioblastoma cells, and circ_0012381 entered the microglia via exosomes. circ_0012381 induced M2 polarization in microglia by sponging with miR-340-5p to increase ARG1 expression. M2-polarized microglia suppressed phagocytosis and promoted the growth of the irradiated glioblastoma cells by CCL2/CCR2 axis. Compared with the effects of radiotherapy alone, the inhibition of exosomes significantly inhibited the growth of irradiated glioblastoma cells in a zebrafish model.
Conclusions
Our data suggested that the inhibition of exosome secretion might represent a potential therapeutic strategy to increase the efficacy of radiotherapy in patients with glioblastoma.
Cytotoxicity of combinations of the pan-KRAS SOS1 inhibitor BAY-293 against pancreatic cancer cell lines
Authors: Plangger Adelina , Rath Barbara , Stickler Sandra , Hochmair Maximilian , Lang Clemens , Weigl Lukas , Funovics Martin , Hamilton Gerhard
Published: July 2022

KRAS is mutated in approximately 25% of cancer patients and first approved KRAS G12C-specific inhibitors showed promising responses. Pancreatic cancer has the highest frequency of KRAS mutations but the prevailing KRAS G12D mutation is difficult to target. Inhibition of the GTP exchange factor (GEF) SOS1 – KRAS interaction impairs oncogenic signaling independently of the specific KRAS mutations. In general, cell lines exhibiting KRAS mutations show specific alterations in respect to glucose utilization, signal transduction and stress survival. The aim of this investigation was to check the putative synergy of the SOS1 inhibitor BAY-293 with modulators targeting specific vulnerabilities of KRAS-mutated cell lines in vitro. The cytotoxicity of BAY-293 combinations was tested against MIA PaCa-2 (G12C), AsPC1 (G12D) and BxPC3 (KRAS wildtype) cell lines using MTT tests and calculation of the combination indices (CI) according to the Chou-Talalay method. The results show that BAY-293 synergizes with modulators of glucose utilization, inhibitors of the downstream MAPK pathway and several chemotherapeutics in dependence of the specific KRAS status of the cell lines. In particular, divergent responses for Bay-293 combinations between pancreatic and NSCLC cell lines were observed for Linsitinib, superior inhibitory effects of Trametinib and PD98059 in NSCLC, and lack of activity with Doxorubicin in case of the pancreatic cell lines. Phosphoproteome analysis revealed inhibition of distinct signaling pathways by Bay-293 for MIA PaCa-2 on the one hand and for Aspc1 and BH1362 on the other hand. In conclusion, BAY-293 exhibits synergy with drugs in dependence of the tumor type and specific KRAS mutation.