bluuebunny/crossref_metadata_2025 huggingface dataset:
Inertial and dimensional effects on the instability of a thin film
Authors: González Alejandro G. , Diez Javier A. , Sellier Mathieu
Published: December 2015

We consider here the effects of inertia on the instability of a flat liquid film under the effects of capillary and intermolecular forces (van der Waals interaction). Firstly, we perform a linear stability analysis within the long-wave approximation, which shows that the inclusion of inertia does not produce new regions of instability other than the one previously known from the usual lubrication case. The wavelength, ${\it\lambda}_{m}$, corresponding to the maximum growth, ${\it\omega}_{m}$ and the critical (marginal) wavelength do not change. The most affected feature of the instability under an increase of the Laplace number is the noticeable decrease of the growth rates of the unstable modes. In order to put in evidence the effects of the bidimensional aspects of the flow (neglected in the long-wave approximation), we also calculate the dispersion relation of the instability from the linearized version of the complete Navier–Stokes (N–S) equations. Unlike the long-wave approximation, the bidimensional model shows that ${\it\lambda}_{m}$ can vary significantly with inertia when the aspect ratio of the film is not sufficiently small. We also perform numerical simulations of the nonlinear N–S equations and analyse to which extent the linear predictions can be applied depending on both the amount of inertia involved and the aspect ratio of the film.
Association of protein intake with the change of lean mass among elderly women: The Osteoporosis Risk Factor and Prevention – Fracture Prevention Study (OSTPRE-FPS)
Authors: Isanejad Masoud , Mursu Jaakko , Sirola Joonas , Kröger Heikki , Rikkonen Toni , Tuppurainen Marjo , Erkkilä Arja T.
Published: December 2015

Low protein intake can lead to declined lean mass (LM) in elderly. We examined the associations of total protein (TP), animal protein (AP) and plant protein (PP) intakes with LM. The association of TP intake with LM change was further evaluated according to weight change status. This cross-sectional and prospective cohort study included 554 women aged 68 (sd 1·9) years from the Osteoporosis Risk Factor and Prevention – Fracture Prevention Study (OSTPRE-FPS). The intervention group (n 270) received daily cholecalciferol (800 IU; 20 μg) and Ca (1000 mg) for 3 years while the control group received neither supplementation nor placebo (n 282). Participants filled out a questionnaire on lifestyle factors and a 3-d food record in 2002 and underwent dual-energy X-ray absorptiometry for body composition measurements at baseline and 3 years. Multiple linear regressions evaluated the association between protein intake and LM, adjusting for relevant covariates. At the baseline TP and AP intakes were positively associated with LM and trunk LM, TP was associated also with appendicular LM (aLM). Follow-up results showed that in the total population and the intervention group, higher TP and AP were associated with increased LM and aLM (P ≤ 0·050). No such associations were observed in the control group. PP intake was also associated with aLM change in the total population. Overall, the associations were independent of fat mass. Further, among weight maintainers, TP intake was positively associated with LM, aLM and trunk LM changes (P ≤ 0·020). In conclusion, dietary TP, especially AP, intake may be a modifiable risk factor for sarcopenia by preserving LM in the elderly.
Middle-range exploratory activity in adult rats suggests higher resilience to chronic social defeat
Authors: Matrov Denis , Kõiv Kadri , Kanarik Margus , Peet Krista , Raudkivi Karita , Harro Jaanus
Published: December 2015

Objective

Stressful life events play an important role in the aetiology of human mood disorders and are frequently modelled by chronic social defeat (SD) in rodents. Exploratory phenotype in rats is a stable trait that is likely related to inter-individual differences in reactivity to stress. The aim of the study was to confirm that low levels of exploratory activity (LE) are, in rodents, a risk factor for passive stress coping, and to clarify the role of medium (ME) and high (HE) exploratory disposition in the sensitivity to SD.

Methods

We examined the effect of SD on male Wistar rats with LE, ME, and HE activity levels as measured in the exploration box. After SD, the rats were evaluated in social preference, elevated zero maze, and open-field tests. Brain tissue levels of monoamines were measured by high-performance liquid chromatography.

Results

Rats submitted to SD exhibited lower weight gain, higher sucrose consumption, showed larger stress-induced hyperthermia, lower levels of homovanillic acid in the frontal cortex, and higher levels of noradrenaline in the amygdala and hippocampus. Open-field, elevated zero maze, and social preference tests revealed the interaction between stress and phenotype, as only LE-rats were further inhibited by SD. ME-rats exhibited the least reactivity to stress in terms of changes in body weight, stress-induced hyperthermia, and sucrose intake.

Conclusion

Both low and high novelty-related activity, especially the former, are associated with elevated sensitivity to social stress. This study shows that both tails of a behavioural dimension can produce stress-related vulnerability.
Exhibition: 'Tracey Moffatt: Spirited', Queensland Art Gallery, Gallery of Modern Art, 25 October 2014 to 8 February 2015
Authors: Bernal Abigail
Published: December 2015

Tracey Moffatt: Spirited, Queensland Art Gallery, Gallery of Modern Art, 25 October 2014 to 8 February 2015
A f/oxymoron?
Authors: Felton Emma
Published: December 2015

Donald Horne famously wrote, ‘Australia was born urban and quickly grew suburban’ (1964), an observation that carries a weight of assumptions about suburban living. Historically, the Australian suburbs have been regarded as places of retreat, family life and female activity, and subsequently as a place where not much of interest happens. By contrast, a city’s central areas are seen as more dynamic spaces and, with recent creative city thinking and planning, as potential powerhouses of innovation and creativity. This article challenges assumptions about suburban living as passive places of retreat through an examination of women in the creative workforce who are living and working in the suburbs. It draws on historical accounts of creative suburban activity and a research project that mapped and investigated the experience of creative workers in the outer suburbs of Brisbane and Melbourne. The study finds that there is much creative work occurring in suburban localities, but this is not as unusual as might be expected.
Effects of supplementation with a calcium-rich marine-derived multi-mineral supplement and short-chain fructo-oligosaccharides on serum lipids in postmenopausal women
Authors: Cronin Barbara E. , Allsopp Philip J. , Slevin Mary M. , Magee Pamela J. , Livingstone M. Barbara E. , Strain J. J. , McSorley Emeir M.
Published: December 2015

Recent literature suggests that Ca supplements have adverse effects on cardiovascular health. The effects of a Ca-rich supplement administered alone or in combination with short-chain fructo-oligosaccharides (scFOS) on serum lipids in postmenopausal women were examined using secondary data from a 24-month double-blind randomised controlled study. A total of 300 postmenopausal women were randomly assigned to daily supplements of 800 mg of Ca (2·4 g Aquamin) (Ca), 800 mg of Ca with 3 g of scFOS (CaFOS) or control (maltodextrin) (MD). A full lipid profile, body composition, blood pressure and a range of cytokines were measured at baseline and after 24 months. Intention-to-treat ANCOVA assessed treatment effects between the groups. A significant time-by-treatment effect was observed for LDL and total cholesterol for the Ca and CaFOS groups, with both groups having lower LDL and total cholesterol concentrations compared with MD after 24 months. The control group had mean (5·2 mmol/l) total cholesterol concentrations above the normal range (≤5 mmol/l) at 24 months, whereas values remained within the normal range in the treatment groups. There was no significant treatment effect on HDL-cholesterol, TAG, body composition, blood pressure or cytokine concentrations at 24 months, with the exception of IL-4, where there was a significant increase in the CaFOS group compared with the placebo. This study demonstrates a lipid-lowering effect of both the Ca-rich supplement alone and the supplement with scFOS. At the 4-year follow-up, there was no significant difference between the groups for reported diagnosed cardiovascular conditions.
Research Note: A Profile of Ministerial Policy Staff in the Government of Canada
Authors: Wilson R. Paul
Published: December 2015

Although ministerial political advisors are prominent and influential actors within the core executive in Canada and elsewhere, information is scarce with respect to their personal and professional backgrounds and career trajectory. This article uses recent survey data and publicly available biographical information to analyse the demographic composition of senior ministerial policy advisors within the Government of Canada. It finds that, while ministerial policy staffers are young and politically committed, they are not so young nor so professionally inexperienced as sometimes thought. Nor are they always personally and tightly bound to their current ministers but often work for different ministers in different departments. This suggests that advisors are agents of the whole government as much as agents of their individual ministers and raises questions about the degree to which they are responsive to the Prime Minister's Office, thereby increasing centralization.
“Bringing Cities Back In” To Canadian Political Science: Municipal Public Policy and Immigration
Authors: Fourot Aude-Claire
Published: December 2015

Usually, the state of urban research in Canadian political science leads to pessimistic evaluations. This pessimism is belied by one emerging area of study: research on Canadian municipal public policies and immigration, which has flourished over the last 20 years. This article tracks the evolution of this research. First, I retrace how municipal policies for immigrants have been studied, and show how comparison is a central component of this literature. Second, I analyze the dynamics of agenda setting, as well as variables for decision making and implementation. Third, I make three propositions for future research, which are i) to examine the reciprocal relationship between attitudes towards immigration and local public policies and politics; ii) to study local public policy as constructions rather than responses and iii) to revisit the use of national models of integration for cities. In conclusion, I underline the positive outcomes of “bringing cities back in” to Canadian political science, not only to better understand political regulation and Canadian federalism, but also to have a more complete view of the immigrant integration policies.
Hate Speech and Identity Politics in Germany, 1848–1914
Authors: Goldberg Ann
Published: December 2015

A dramatic paradigm shift has occurred in European and German hate-speech laws, from their nineteenth-century origins in repressive campaigns against the Left to their present association with pluralism, tolerance, and minority rights. This article rethinks the timing and causes of that shift, arguing that, contrary to the prevailing scholarship, the decade of the 1890s—not 1945—constituted the first key turning point toward a human-rights model of hate-speech law. Departing from a more traditional legal historiography focused on formal legal institutions and laws, the article examines law “from below” as social and political practice. The results show how, in the 1890s, a new vision of hate speech began to take shape when a grassroots Jewish defense movement began to appropriate and reshape the law in order to oppose antisemites. In theoretical terms, the article's method of examining the interaction of law and politics shows that from the 1840s onward, the politics surrounding hate-speech law refutes simple binary constructions that cast German legal culture as “dignitarian” and distinct from U.S. “libertarianism.”
Sex and the Soldier: The Discourse about the Moral Conduct of Bundeswehr Soldiers and Officers during the Adenauer Era
Authors: Brühöfener Friederike
Published: December 2015

This article situates the establishment of the Bundeswehr and the implementation of compulsory military service in the 1950s and early 1960s within contemporary efforts to define a “sexual-moral order” for the Federal Republic of Germany. It argues that West Germany's rearmament offered contemporaries an opportunity to stipulate not only acceptable soldierly behavior, but also adequate male behavior in general. In the context of heightened concerns about juvenile delinquents (so-called Halbstarken), female prostitution, homosexuality, and the distribution of pornographic materials, West German citizens became interested in the social and sexual conduct of Bundeswehr soldiers and officers. Whereas some still considered the military to be a “school of the nation” and of proper masculinity, others worried about the armed forces as a possible breeding ground for immorality. Partly sharing these concerns, government representatives, members of the Bundestag, church officials, and military commanders sought to guide soldiers’ behavior, emphasizing the ideal of the “complete” (vollkommene) Christian male-breadwinner family.
The Determinants of Plant Survival in the U.S. Radio Equipment Industry During the Great Depression
Authors: Scott Peter , Ziebarth Nicolas
Published: December 2015

Automobile manufacture is generally regarded as the paradigmatic mass production industry, with large plants able to exploit scale economies. We argue that the radio industry also sheds important light on evolving production technology and determinants of competitive success in inter-war manufacturing. Timothy F. Bresnahan and Daniel M.G. Raff (1991) showed that productivity differences resulting from scale in the auto industry translated into differences in exit rates during the Depression. We find that technical scale economies did not play a large role in the radio industry. Instead selection during the Depression was on non-“technical” productivity factors, including whether or not a plant's parent company owned a brand.
Flip the Switch: The Impact of the Rural Electrification Administration 1935–1940
Authors: Kitchens Carl , Fishback Price
Published: December 2015

To isolate the impact of access to electricity on local economies, we examine the impact of the Rural Electrification Administration low-interest loans in the 1930s. The REA provided loans to cooperatives to lay distribution lines to farms and aid in wiring homes. Consequently, the number of rural farm homes electrified doubled in the United States within five years. We develop a panel data set for the 1930s and use changes within counties over time to identify the effect of the REA loans on a wide range of socio-economic measures. The REA loans contributed significantly to increases in crop output and crop productivity and helped stave off declines in overall farm output, productivity, and land values, but they had much smaller effects on nonagricultural parts of the economy. The ex-ante subsidy from the low-interest loans was large, but after the program was completed, nearly all of the loans were fully repaid, and the ultimate cost to the taxpayer was relatively low.
Comparison of three diagnostic tests in detecting vestibular deficit in patients with peripheral vestibulopathy
Authors: Eza-Nuñez P , Fariñas-Alvarez C , Fernandez N Perez
Published: December 2015

Objectives:

This study aimed to evaluate the results of the video head impulse test and of the caloric and rotatory chair tests in patients with dizziness. Agreement between test results was assessed and the best protocol for detecting peripheral vestibulopathy was identified.

Methods:

Participants comprised 116 patients, 75 with a peripheral vestibulopathy and 41 with non-peripheral vestibulopathy. The main outcome measures were classified as normal or abnormal according to our laboratory data.

Results:

Agreement between tests was low. Vestibulopathy testing that required all three results to be abnormal had a sensitivity of 0.547, a specificity of 0.878, and positive and negative predictive values of 0.891 and 0.514, respectively. Vestibulopathy testing that required just one result to be abnormal had a sensitivity of 0.933, a specificity of 0.292, and positive and negative predictive values of 0.701 and 0.705, respectively.

Conclusion:

In peripheral vestibulopathy, there was weak concordance in the assessment of horizontal semicircular canal function among the different tests. However, the video head impulse test had sufficient statistical power to be recommended as the first-line test.
Facial nerve management in jugular paraganglioma surgery: a literature review
Authors: Odat H , Shin S-H , Odat M A , Alzoubi F
Published: December 2015

Objective:

This literature review analysed facial nerve management strategies in jugular paraganglioma surgery and discusses the tumour resection rate and the facial nerve outcome associated with each technique.

Methods:

A retrospective review of PubMed and Medline articles on the surgical treatments for jugular paraganglioma was performed. Tumour resection rates and post-operative facial nerve function after non-rerouting, short anterior rerouting and long anterior rerouting approaches were evaluated for each article.

Results:

A total of 15 studies involving a total of 688 patients were included. Post-operative facial nerve function was similar after non-rerouting and short anterior rerouting approaches (p= 0.169); however, both of these techniques had significantly better post-operative facial nerve outcomes compared with long anterior rerouting (p< 0.001 andp= 0.001, respectively). The total tumour removal rate was significantly higher for long anterior rerouting than with the non-rerouting approach (p= 0.016). There was no difference in total tumour removal rate between the long and short anterior rerouting approaches (p= 0.067) and between the short anterior rerouting and non-rerouting approaches (p= 0.867).

Conclusion:

No strict guidelines for facial nerve management in jugular paraganglioma resection are available. Although long anterior rerouting provides the best tumour exposure along with a low morbidity rate, case-by-case selection of the surgical approach is recommended.
An alternative framework for responding to the amphibian crisis
Authors: Muths Erin , Fisher Robert N.
Published: December 2015

Volumes of data illustrate the severity of the crisis affecting amphibians, where > 32% of amphibians worldwide are threatened with declining populations. Although there have been isolated victories, the current approach to the issue is unsuccessful. We suggest that a radically different approach, something akin to human emergency response management (i.e. the Incident Command System), is one alternative to addressing the inertia and lack of cohesion in responding to amphibian issues. We acknowledge existing efforts and the useful research that has been conducted, but we suggest that a change is warranted and that the identification of a new amphibian chytrid provides the impetus for such a change. Our goal is to recognize that without a centralized effort we (collectively) are likely to fail in responding to this challenge.
Cognitive inhibition in depression and suicidal behavior: a neuroimaging study
Authors: Richard-Devantoy S. , Ding Y. , Lepage M. , Turecki G. , Jollant F.
Published: December 2015

Background

Cognitive inhibition deficits have previously been found in suicide attempters. This study examined the neural basis for these deficits in depressed patients with and without a history of suicidal behavior.

Method

Functional magnetic resonance imaging was used to measure brain activation during the Go/No-Go response inhibition task in 25 unmedicated and depressed middle-aged suicide attempters, 22 unmedicated depressed patient controls with no personal or family history of suicidal behavior, and 27 healthy controls. Whole-brain analyses were conducted with SPM12.

Results

Suicide attempters exhibited an elevated number of commission errors relative to both control groups. However, suicide attempters did not differ from patient controls in terms of brain activation for any contrast. Analyses showed a significant association between depression and brain activation in the left inferior frontal gyrus and medial thalamus during Gov. No-Go, and in the bilateral parietal cortex and left orbitofrontal cortex during No-Gov. baseline. These regions were correlated with psychological pain, suicidal ideation and global functioning. There was no association between brain activation and personal histories of suicidal act.

Conclusions

Our study suggests that deficits in cognitive inhibition, in relation to the inferior frontal gyrus, thalamus, orbitofrontal cortex and parietal cortex, are related to the depressive state and not specifically to suicide vulnerability. We hypothesize that state-related deficits may add to trait-like cognitive impairments to facilitate suicidal acts. These different types of cognitive impairments may necessitate different therapeutic strategies for the prevention of suicide.
Group cognitive behavioural treatment for insomnia in primary care: a randomized controlled trial
Authors: Cape J. , Leibowitz J. , Whittington C. , Espie C. A. , Pilling S.
Published: December 2015

Background

Insomnia disorder is common and often co-morbid with mental health conditions. Cognitive behavioural therapy (CBT) for insomnia is effective, but is rarely implemented as a discrete treatment. The aim of this study was to evaluate the effectiveness of brief CBT groups for insomnia compared to treatment as usual (TAU) for insomnia delivered by mental health practitioners in a primary-care mental health service.

Method

A total of 239 participants were randomized to either a five-session CBT group or to TAU. Assessments of sleep and of symptoms of depression and anxiety were carried out at baseline, post-treatment and at 20 weeks. Primary outcome was sleep efficiency post-treatment.

Results

Group CBT participants had better sleep outcomes post-treatment than those receiving TAU [sleep efficiency standardized mean difference 0.63, 95% confidence interval (CI) 0.34–0.92]. The effect at 20 weeks was smaller with a wide confidence interval (0.27, 95% CI −0.03 to 0.56). There were no important differences between groups at either follow-up period in symptoms of anxiety or depression.

Conclusions

Dedicated CBT group treatment for insomnia improves sleep more than treating sleep as an adjunct to other mental health treatment.
Early life stress and the anxious brain: evidence for a neural mechanism linking childhood emotional maltreatment to anxiety in adulthood
Authors: Fonzo G. A. , Ramsawh H. J. , Flagan T. M. , Simmons A. N. , Sullivan S. G. , Allard C. B. , Paulus M. P. , Stein M. B.
Published: December 2015

Background

Childhood emotional maltreatment (CEM) increases the likelihood of developing an anxiety disorder in adulthood, but the neural processes underlying conferment of this risk have not been established. Here, we test the potential for neuroimaging the adult brain to inform understanding of the mechanism linking CEM to adult anxiety symptoms.

Method

One hundred eighty-two adults (148 females, 34 males) with a normal-to-clinical range of anxiety symptoms underwent structural and functional magnetic resonance imaging while completing an emotion-processing paradigm with facial expressions of fear, anger, and happiness. Participants completed self-report measures of CEM and current anxiety symptoms. Voxelwise mediation analyses on gray-matter volumes and activation to each emotion condition were used to identify candidate brain mechanisms relating CEM to anxiety in adulthood.

Results

During processing of fear and anger faces, greater amygdala and less right dorsolateral prefrontal (dlPFC) activation partially mediated the positive relationship between CEM and anxiety symptoms. Greater right posterior insula activation to fear also partially mediated this relationship, as did greater ventral anterior cingulate (ACC) and less dorsal ACC activation to anger. Responses to happy faces in these regions did not mediate the CEM-anxiety relationship. Smaller right dlPFC gray-matter volumes also partially mediated the CEM-anxiety relationship.

Conclusions

Activation patterns of the adult brain demonstrate the potential to inform mechanistic accounts of the CEM conferment of anxiety symptoms. Results support the hypothesis that exaggerated limbic activation to negative valence facial emotions links CEM to anxiety symptoms, which may be consequent to a breakdown of cortical regulatory processes.
Genetic overlap between impulsivity and alcohol dependence: a large-scale national twin study
Authors: Khemiri L. , Kuja-Halkola R. , Larsson H. , Jayaram-Lindström N.
Published: December 2015

Background

Alcohol dependence is associated with increased levels of impulsivity, but the genetic and environmental underpinnings of this overlap remain unclear. The purpose of the current study was to investigate the degree to which genetic and environmental factors contribute to the overlap between alcohol dependence and impulsivity.

Method

Univariate and bivariate twin model fitting was conducted for alcohol dependence and impulsivity in a national sample of 16 819 twins born in Sweden from 1959 to 1985.

Results

The heritability estimate for alcohol dependence was 44% [95% confidence interval (CI) 31–57%] for males and 62% (95% CI 52–72%) for females. For impulsivity, the heritability was 33% (95% CI 30–36%) in males and females. The bivariate twin analysis indicated a statistically significant genetic correlation between alcohol dependence and impulsivity of 0.40 (95% CI 0.23–0.58) in males and 0.20 (95% CI 0.07–0.33) in females. The phenotypic correlation between alcohol dependence and impulsivity was 0.20 and 0.17 for males and females, respectively, and the bivariate heritability was 80% (95% CI 47–117%) for males and 53% (95% CI 19–86%) for females. The remaining variance in all models was accounted for by non-shared environmental factors.

Conclusions

The association between alcohol dependence and impulsivity can be partially accounted for by shared genetic factors. The genetic correlation was greater in men compared with women, which may indicate different pathways to the development of alcohol dependence between sexes. The observed genetic overlap has clinical implications regarding treatment and prevention, and partially explains the substantial co-morbidity between alcohol dependence and psychiatric disorders characterized by impulsive behaviour.
Three decades of eating disorders in Dutch primary care: decreasing incidence of bulimia nervosa but not of anorexia nervosa
Authors: Smink F. R. E. , van Hoeken D. , Donker G. A. , Susser E. S. , Oldehinkel A. J. , Hoek H. W.
Published: December 2015

Background

Whether the incidence of eating disorders in Western, industrialized countries has changed over time has been the subject of much debate. The purpose of this primary-care study was to examine changes in the incidence of eating disorders in The Netherlands during the 1980s, 1990s and 2000s.

Method

A nationwide network of general practitioners (GPs), serving a representative sample (~1%) of the total Dutch population, recorded newly diagnosed patients with anorexia nervosa (AN) and bulimia nervosa (BN) in their practice during 1985–1989, 1995–1999, and 2005–2009. GPs are key players in the Dutch healthcare system, as their written referral is mandatory in order to get access to specialized (mental) healthcare, covered by health insurance. Health insurance is virtually universal in The Netherlands (99% of the population). A substantial number of GPs participated in all three study periods, during which the same case identification criteria were used and the same psychiatrist was responsible for making the final diagnoses. Incidence rates were calculated and for comparison between periods, incidence rate ratios.

Results

The overall incidence rate of BN decreased significantly in the past three decades (from 8.6 per 100 000 person-years in 1985–1989 to 6.1 in 1995–1999, and 3.2 in 2005–2009). The overall incidence of AN remained fairly stable during three decades, i.e. 7.4 per 1 00 000 person-years in 1985–1989, 7.8 in 1995–1999, and 6.0 in 2005–2009.

Conclusions

The incidence rate of BN decreased significantly over the past three decades, while the overall incidence rate of AN remained stable.
Respect for patient autonomy as a medical virtue
Authors: Cook Thomas , Mavroudis Constantine D. , Jacobs Jeffrey P. , Mavroudis Constantine
Published: December 2015

Respect for patient autonomy is an important and indispensable principle in the ethical practice of clinical medicine. Legal tenets recognise the centrality of this principle and the inherent right of patients of sound mind – properly informed – to make their own personal medical decisions. In the course of everyday medical practice, however, challenging cases may result in ethical dilemmas for the patient, the physician, and society. Resolution of these dilemmas requires a thorough understanding of the underlying principles that allow the clinician to make informed decisions and to offer considered therapeutic options to the patient. We argue in this paper that there is also need for a transition of moral competency from understanding principles to attaining virtue in the classic Aristotelian tradition. Achieving moral virtue is based on a lifetime of learning, practising, and watching how others, who have achieved virtue, act and perform their duties. We further claim that learning moral virtue in medical practice is best realised by incorporating the lessons learnt during daily rounds where frank discussions and considered resolutions can occur under the leadership of senior practitioners who have achieved a semblance of moral excellence.
How best to assess right ventricular function by echocardiography
Authors: DiLorenzo Michael P. , Bhatt Shivani M. , Mercer-Rosa Laura
Published: December 2015

Right ventricular function is a crucial determinant of long-term outcomes of children with heart disease. Quantification of right ventricular systolic and diastolic performance by echocardiography is of paramount importance, given the prevalence of children with heart disease, particularly those with involvement of the right heart, such as single or systemic right ventricles, tetralogy of Fallot, and pulmonary arterial hypertension. Identification of poor right ventricular performance can provide an opportunity to intervene. In this review, we will go through the different systolic and diastolic indices, as well as their application in practice. Quantification of right ventricular function is possible and should be routinely performed using a combination of different measures, taking into account each disease state. Quantification is extremely useful for individual patient follow-up. Laboratories should continue to strive to optimise reproducibility through quality improvement and quality assurance efforts in addition to investing in technology and training for new, promising techniques, such as three-dimensional echocardiography.
Pregnancy in complex CHD: focus on patients with Fontan circulation and patients with a systemic right ventricle
Authors: Khan Abigail , Kim Yuli Y.
Published: December 2015

The majority of children with congenital heart disease (CHD) now survive into adulthood, and many women with CHD want to pursue pregnancy. Pregnancy represents a complex issue for the CHD care provider. It requires balancing the interests of the woman against the risk to her health during pregnancy, while also factoring in the long-term risks to her health and the risk to her fetus. Our knowledge about this subject has been historically limited by lack of data regarding the outcome of pregnancy in CHD; however, in recent years, more data have begun to emerge. In this review, we will summarise what is known about risk assessment in pregnant CHD patients. We provide a framework for healthcare providers managing pregnancy in this population, with focus on the systemic right ventricle and the Fontan operation.
Social media in paediatric heart disease: professional use and opportunities to improve cardiac care
Authors: Schumacher Kurt R. , Lee Joyce M. , Pasquali Sara K.
Published: December 2015

Social media is any type of communication utilising electronic technology that follows two guiding principles: free publishing or sharing of content and ideas and group collaboration and inter-connectedness. Over the last 10 years, social media technology has made tremendous inroads into all facets of communication. Modalities such as Facebook, YouTube, and Twitter are no longer viewed as new communication technologies. Owing to their tremendous usage, they are now common ways to conduct a dialogue with individuals and groups. Greater than 91% of teenagers and 89% of young adults routinely use social media. Further, 24% of teenagers reported being online “almost constantly”. These forms of communication are readily used by individuals cared for in the field of paediatric cardiology; thus, they should carry significant interest for cardiology care providers; however, social media’s influence on medicine extends beyond use by patients. It directly affects all medical providers, both users and non-users. Further, social media has the ability to improve care for patients with paediatric heart disease. This article details social media’s current influence on paediatric cardiology, including considerations for professional use of social media and potential opportunities to improve cardiac care.
Biomarkers in paediatric heart failure: is there value?
Authors: Lin Kimberly Y.
Published: December 2015

A biomarker is any measurable, surrogate characteristic, which reflects either the presence or the absence of a disease state. This can be a blood test, an imaging characteristic, an exercise parameter, and even a genetic profile. Serum biomarkers are particularly attractive in that their cost to the patient is relatively low in terms of money, time, risk, and ease of obtaining a sample. The potential benefits of a good biomarker are manifold. This manuscript will review serum biomarkers of proposed utility in paediatric heart failure, especially with respect to their ability to aid clinical decision making, diagnosis, and prognosis.
Surveillance of fetal arrhythmias in the outpatient setting: current limitations and call for action
Authors: Freire Grace
Published: December 2015

Surveillance of fetal arrhythmias in the outpatient setting remains limited by lack of monitoring modalities. Despite technological advances made in the field of obstetrics, existing devices are not currently suitable to monitor fetal arrhythmias. In this report, the author describes the current and developing fetal heart rate monitoring technologies including the recent introduction of hand-held Doppler monitors for outpatient surveillance of fetal arrhythmias.
Resisting Parity: Gender and Cabinet Appointments in Chile and Spain
Authors: Franceschet Susan , Thomas Gwynn
Published: December 2015

Presidents and prime ministers possess vast powers of appointment. These powers can be used to appoint cabinets with an equal number of male and female ministers. Parity cabinets make dramatic statements about gender, representation, and political power. They imply that gender balance—rather than just adding some women—is needed to overcome women's political marginalization. Cabinets with just a few token women are insufficient and undemocratic. Yet appointing women in the same proportions as men challenges a status quo in which men occupy most of the positions of power. Even when leaders possess the formal authority to appoint ministers, forming a parity cabinet means that some existing practices and norms, particularly the norm of male dominance, have been broken. Parity cabinets thus create the possibility of backlash from those who fear reduced opportunities for men to access powerful posts.
Letting Down the Ladder or Shutting the Door: Female Prime Ministers, Party Leaders, and Cabinet Ministers
Authors: O'Brien Diana Z. , Mendez Matthew , Peterson Jordan Carr , Shin Jihyun
Published: December 2015

In October 2012 the Danish Socialist People's Party chose Annette Vilhelmsen as its leader. With her ascension to power, women simultaneously headed all three of Denmark's governing parties for the first time. Though an exclusively female-led coalition government remains exceptional, in developed democracies the number of female prime ministers and party leaders has grown in recent years. Since 2000, women have governed in Denmark, Germany, Finland, Iceland, New Zealand, and Australia and have commanded coalition partner parties in Austria, Ireland, and Sweden. Just as there are now more female leaders, governments are also nominating more women to cabinets than ever before. Women recently held half of all ministerial posts in Finland, Iceland, Sweden, and Spain. Female ministers are also serving in high-prestige portfolios from which they were traditionally excluded, including finance and foreign affairs.
Sex, Survival, and Scandal: A Comparison of How Men and Women Exit Presidential Cabinets
Authors: Escobar-Lemmon Maria C. , Taylor-Robinson Michelle M.
Published: December 2015

The process of selecting cabinet ministers often takes place behind closed doors, including weighing the need to balance or manage factions within the president's party and/or coalition partners; addressing demands for diversity in the cabinet, such as appointment of women or other historically underrepresented groups; sending signals about the administration's policy agenda; and enabling the president to have people he or she trusts close at hand. On the other hand, ministerial exits are usually less private affairs. In some cases they come after weeks of public or congressional scrutiny and criticism of ministers for policy failures or follow extended speculation about who will lose their seat when the president reshuffles the cabinet. Some ministers depart to pursue lucrative private-sector opportunities. Other ministers switch posts but stay in government. How ministers exit can have implications for the administration since a president who is frequently forced to shuffle the cabinet or sack ministers looks ineffective, and comparisons to rats and sinking ships are difficult to avoid in the wake of excessive changes. At the same time, an administration with zero turnover may also not be healthy, as it would suggest that presidents are staidly bound to their initial course of action and unable (or unwilling) to adapt to changing circumstances.
Introduction
Authors: Kenny Meryl , Verge Tània
Published: December 2015

Twenty years ago, Pippa Norris and Joni Lovenduski published the classic work Political Recruitment: Gender, Race and Class in the British Parliament (1995), one of the most comprehensive accounts of legislative recruitment thus far. Seeking to explain the social bias evident in legislatures worldwide, Norris and Lovenduski focused on the central role of political parties, arguing that the outcome of parties’ selection processes could be understood in terms of the interaction between the supply of candidates wishing to stand for office and the demands of party gatekeepers who select the candidates. Indeed, in most countries, political parties control not only which candidates are recruited and selected, but also are the central actors involved in adopting and implementing candidate selection reforms such as gender quotas. Yet, two decades later, systematic studies of the “secret garden” of candidate selection and recruitment have been few and far between in the gender and politics literature. It therefore seems a particularly appropriate time to revisit the core preoccupations, puzzles, and challenges that remain in the field of gender and political recruitment.
The Gender Regime of Political Parties: Feedback Effects between “Supply” and “Demand”
Authors: Verge Tània
Published: December 2015

Is women's chronic minority status worldwide explained by a lack of women wishing to stand for political office or by party selectors’ disinterest in selecting women candidates? This debate continues among gender politics scholars; however, an increasing number of studies highlight the need to further investigate how the demands of party selectors might shape the supply of women candidates, especially in strong parliamentary democracies where political parties are the key gatekeepers (Kenny 2013; Murray 2010). This concern was already present in Norris and Lovenduski's (1995) original model, which called for a deeper examination of the “interaction effects” between “supply” and “demand.” In engaging with this call, I argue that the constraining effects of supply are reinforced not only by the demands of party selectors, but also by the everyday (gendered) functioning of political parties, which helps us understand the differential chances of women and men eventually becoming candidates.
Broad band circularly polarized square slot array antenna with improved sequentially rotated feed network for C-band application
Authors: Bairami Puria , Zavvari Mahdi
Published: December 2015

In this paper, an array antenna with asymmetric antenna fed network is presented. Total size of the proposed array antenna (with 2 × 2 elements) is 90 × 90 mm2 and distance between elements (fed by fed) is λ0/2 (λ0 = wavelength in free space). The proposed antenna is fed by coaxial cable that isolated input impedance from impedance of the array antenna feed network. The measured impedance bandwidth of the coaxial fed circular polarization array (S11 < −10 dB) is 47.9% from 4.6 to 7.5 GHz (1.63:1), and the measured 3-dB axial-ratio bandwidth is 42% from 4.7 to 7.2 GHz. The peak gain of antenna is 9.1 dBic.
Correction: Corrigendum: Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression
Authors: Tasaka-Fujita Megumi , Sugiyama Nao , Kang Wonseok , Masaki Takahiro , Murayama Asako , Yamada Norie , Sugiyama Ryuichi , Tsukuda Senko , Watashi Koichi , Asahina Yasuhiro , Sakamoto Naoya , Wakita Takaji , Shin Eui-Cheol , Kato Takanobu
Published: December 2015

Amino acid (aa) polymorphisms in the hepatitis C virus (HCV) genotype 1b core protein have been reported to be a potent predictor for poor response to interferon (IFN)-based therapy and a risk factor for hepatocarcinogenesis. We investigated the effects of these polymorphisms with genotype 1b/2a chimeric viruses that contained polymorphisms of Arg/Gln at aa 70 and Leu/Met at aa 91. We found that infectious virus production was reduced in cells transfected with chimeric virus RNA that had Gln at aa 70 (aa70Q) compared with RNA with Arg at aa 70 (aa70R). Using flow cytometry analysis, we confirmed that HCV core protein accumulated in aa70Q clone transfected cells, and it caused a reduction in cell-surface expression of major histocompatibility complex (MHC) class I molecules induced by IFN treatment through enhanced protein kinase R phosphorylation. We could not detect any effects due to the polymorphism at aa 91. In conclusion, the polymorphism at aa 70 was associated with efficiency of infectious virus production, and this deteriorated virus production in strains with aa70Q resulted in the intracellular accumulation of HCV proteins and attenuation of MHC class I molecule expression. These observations may explain the strain-associated resistance to IFN-based therapy and hepatocarcinogenesis of HCV.
TP53 Mutational Analysis Enhances the Prognostic Accuracy of IHC4 and PAM50 Assays
Authors: Lin Ching-Hung , Chen I-Chiun , Huang Chiun-Sheng , Hu Fu-Chang , Kuo Wen-Hung , Kuo Kuan-Ting , Wang Chung-Chieh , Wu Pei-Fang , Chang Dwan-Ying , Wang Ming-Yang , Chang Chin-Hao , Chen Wei-Wu , Lu Yen-Shen , Cheng Ann-Lii
Published: December 2015

IHC4 and PAM50 assays have been shown to provide additional prognostic information for patients with early breast cancer. We evaluated whether incorporating TP53 mutation analysis can further enhance their prognostic accuracy. We examined TP53 mutation and the IHC4 score in tumors of 605 patients diagnosed with stage I–III breast cancer at National Taiwan University Hospital (the NTUH cohort). We obtained information regarding TP53 mutation and PAM50 subtypes in 699 tumors from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort. We found that TP53 mutation was significantly associated with high-risk IHC4 group and with luminal B, HER2-enriched and basal-like subtypes. Despite the strong associations, TP53 mutation independently predicted shorter relapse-free survival (hazard ratio [HR] = 1.63, P = 0.007) in the NTUH cohort and shorter breast cancer-specific survival (HR = 2.35, P = <0.001) in the METABRIC cohort. TP53 mutational analysis added significant prognostic information in addition to the IHC4 score (∆ LR-χ2 = 8.61, P = 0.002) in the NTUH cohort and the PAM50 subtypes (∆ LR-χ2 = 18.9, P = <0.001) in the METABRIC cohort. We conclude that incorporating TP53 mutation analysis can enhance the prognostic accuracy of the IHC4 and PAM50 assays.
Effectiveness of Chinese herbal medicine for cancer palliative care: overview of systematic reviews with meta-analyses
Authors: Chung Vincent CH , Wu Xinyin , Hui Edwin P. , Ziea Eric TC , Ng Bacon FL , Ho Robin ST , Tsoi Kelvin KF , Wong Samuel YS , Wu Justin CY
Published: December 2015

Chinese herbal medicines (CHM) are often used in managing cancer related symptoms but their effectiveness and safety is controversial. We conducted this overview of meta-analyses to summarize evidence on CHM for cancer palliative care. We included systematic reviews (SRs) with meta-analyses of CHM clinical trials on patients diagnosed with any type of cancer. Methodological quality of included meta-analyses was assessed with the Methodological Quality of Systematic Reviews (AMSTAR) Instrument. Fifty-one SRs with meta-analyses were included. They covered patients with lung (20 SRs), gastric (8 SRs), colorectal (6 SRs), liver (6 SRs), breast (2 SRs), cervical (1 SR), esophageal (1 SR) and nasopharyngeal (1 SR) cancers. Six SRs summarized evidence on various types of cancer. Methodological quality of included meta-analyses was not satisfactory. Overall, favorable therapeutic effects in improving quality of life among cancer patients have been reported. Conflicting evidence exists for the effectiveness of CHM in prolonging survival and in reducing chemotherapy and/or radiotherapy related toxicities. No serious adverse effects were reported in all included studies. Evidence indicated that CHM could be considered as an option for improving quality of life among patients receiving palliative care. It is unclear if CHM may increase survival, or reduce therapy related toxicities.