bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of Conduct Problem Youth with Interpersonal Callous Traits Using Mental Models: Measurement of Risk and Change
Authors: Salekin Randall T. , Tippey Jacalyn G. , Allen Alesia D.
Published: July 2012

The present study examined a newly developed intervention for conduct problem youth with callous unemotional (CU) traits. Specifically, we examined the effects of a mental models intervention designed to increase motivation, raise positive emotion, and decrease interpersonal callousness in youth. We then measured change on the treatment scale of a risk and management measure for young offenders, namely the Risk‐Sophistication‐Treatment Inventory – Self Report (RSTI‐SR; Iselin & Salekin, 2008). The design of the study involved administering a test battery to youth in a secure residential facility pre‐, mid‐, and post‐treatment. Findings showed increases in positive emotion and treatment amenability scores and reduced psychopathy scores across the intervention. Reductions in symptoms were evidenced across the facets of interpersonal, callous and impulsive psychopathy traits. Similarly, gains on the RSTI‐SR treatment scale were multidimensional. The current study revealed three important findings. First, positive emotion was shown to increase in youth across the intervention. Second, the new intervention was effective at reducing interpersonal callous traits in youth, as well as improving their amenability to treatment. Third, the RSTI‐SR appeared to be an effective measure for indexing change. Copyright © 2012 John Wiley & Sons, Ltd.
The sinuvertebral nerves at the craniovertebral junction: A microdissection study
Authors: Rennie C. , Haffajee M.R. , Ebrahim M.A.A.
Published: July 2012

Bogduk et al. (1988, Spine 13:2–8) noted that the joints and ligaments at the cervico‐occipital region are susceptible to whiplash injury. The upper three cervical sinuvertebral nerves (SVNs) at the craniovertebral junction (CVJ) are thought to be responsible for mediating pain from the ligaments, dura mater, and soft tissues of the posterior cranial fossa and upper cervical column. The purpose of this study was to describe in detail the origin and course of the SVNs at C0–C1, C1–C2, and C2–C3 intervertebral levels and their anterior intraspinal distribution. A sample comprising 10 adult, 12 fetal (crown rump length = 155–250 mm), and three stillborn neonatal (n = 50 sides) embalmed cadaveric cervical spines was microdissected (Carl Zeiss, Jena, Germany, 8–40× magnification). A laminectomy of the cervical spine with an occipital craniectomy (seven adult and all fetal specimens) or a horizontal section of the intervertebral levels was performed (three adult specimens) to expose the craniocervical canal. In both adult and fetal specimens, all three cervical SVNs arose from two roots, a somatic root (from the spinal nerve or ventral ramus or both) and a sympathetic root (from the vertebral artery plexus or superior cervical ganglion). The C1 and C2 SVNs were variable in number. The C2 and C3 SVN innervated most of the structures at the CVJ as well as the basiocciput region. The C1 SVN supplied a very small part of the atlanto‐occipital joint area. The intraspinal courses of all three SVNs consisted of ascending and descending branches closely adherent to the arteries of the CVJ. They supplied the dura mater, the ligaments, adjacent joints, and soft tissues by tiny branches from the main branches. The detailed origins and course are described. Clin. Anat. 2013. © 2012 Wiley Periodicals, Inc.
Production of the Quorum‐Sensing Molecules N‐Acylhomoserine Lactones by Endobacteria Associated with Mortierella alpina A‐178
Authors: Kai Kenji , Furuyabu Kana , Tani Ayaka , Hayashi Hideo
Published: July 2012

Gram‐negative bacteria communicate with one another using N‐acylhomoserine lactones (AHLs) as signaling molecules. This mechanism, known as quorum sensing (QS), is needed to develop pathogenicity, as well as symbiotic interactions with eukaryotic hosts, such as animals and plants. Increasing evidence indicates that certain bacteria, namely endobacteria, also inhabit fungal cells and establish symbiotic relationships with their hosts. However, it has not been clear whether bacterial QS acts in developing the relationships. Here we describe the isolation and identification of N‐heptanoylhomoserine lactone and N‐octanoylhomoserine lactone from the culture broth of the zygomycete fungus Mortierella alpina A‐178. This suggested the presence of endobacteria in the fungus, as was confirmed by PCR, fluorescence in situ hybridization, and transmission electron microscopy. Two major bands obtained by PCR‐denaturing gradient gel electrophoresis showed sequence identity to genes in the β‐proteobacterium Castellaniella defragrans (100 %) and the Gram‐positive bacterium Cryobacterium sp. (99.8 %). The production of AHLs depended on the presence of endobacteria and was induced in response to the increase in the concentration of AHLs, suggesting that the bacterium conducts AHL‐mediated QS in the fungus. This paper is the first to report the production of AHLs by endofungal bacteria and raises the possibility that QS plays roles in the development of fungus–endobacterium symbiosis.
Ru–Cd/Bentonite for the Partial Hydrogenation of Benzene: A Catalyst without Additives
Authors: Wang Weitao , Liu Huizhen , Ding Guodong , Zhang Peng , Wu Tianbin , Jiang Tao , Han Buxing
Published: July 2012

Clays are very promising, environmentally benign catalyst supports. Herein, Ru–Cd/bentonite (BEN) catalysts were prepared and characterized by TEM, SEM, XPS, and XRD. The as‐prepared catalysts were used to catalyze the selective hydrogenation of benzene into cyclohexene with different Ru/Cd molar ratios, hydrogen pressures, and reaction temperatures. We found that the catalytic activity decreased with decreasing Ru/Cd molar ratio, whereas the selectivity was enhanced. The most‐favorable Ru/Cd molar ratio was 1 and the optimal hydrogen pressure and temperature were 5 MPa and 150 °C, respectively. The yield of cyclohexene reached 24.8 % over Ru–Cd/BEN under the optimal reaction conditions without the need for any additives in the reaction system and this catalyst could be reused several times in the reaction without a drop in the yield of cyclohexene. The Cd in the catalyst enhanced the selectivity for cyclohexene. Furthermore, Cd/BEN could be used an as effective supported additive to promote the hydrogenation of benzene into cyclohexene catalyzed by Ru/BEN or Ru/SBA‐15.
Gold Nanoparticle‐Catalyzed Formation of Nitrogen‐containing Compounds—From Mechanistic Understanding to Synthetic Exploitation
Authors: Mielby Jerrik , Kegnæs Søren , Fristrup Peter
Published: July 2012

During the last decade, heterogeneous catalysis using gold nanoparticles has gained importance as an efficient method for the oxidation of alcohols and aldehydes. The scope of these reactions has recently been extended to nitrogen‐containing compounds, which is a particularly promising substrate class, as nitrogen is ubiquitous in both materials science and biology. It has been shown that gold nanoparticles can overcome many of the frequently encountered difficulties caused by the coordinating properties of nitrogen when using homogenous catalysis. This minireview is meant to serve as an entry point for new researchers in this emerging field and is divided into sections based upon which nitrogen‐containing products are synthesized using gold nanoparticles in the critical reaction step.
Sterically Active Electron Pairs in Lead Sulfide? An Investigation of the Electronic and Vibrational Properties of PbS in the Transition Region Between the Rock Salt and the α‐GeTe‐Type Modifications
Authors: Zagorac Dejan , Doll Klaus , Schön J. Christian , Jansen Martin
Published: July 2012

Recently, we have investigated the energy landscape of PbS for many different pressures on the ab initio level by using Hartree–Fock and density functional theory to globally search for possible thermodynamically stable and metastable structures. The perhaps most fascinating observation was that besides the experimentally known modification exhibiting the rock salt structure a second minimum exists close‐by on the landscape showing the low‐temperature α‐GeTe‐type structure. In the present study, we investigate the possible reasons for the existence of this metastable modification; in particular we address the question, whether the α‐GeTe‐type modification might be stabilized (and conversely the rock salt modification destabilized) by steric effects of the non‐bonding electron pair.
Structures of Chlorophyll Catabolites in Bananas (Musa acuminata) Reveal a Split Path of Chlorophyll Breakdown in a Ripening Fruit
Authors: Moser Simone , Müller Thomas , Holzinger Andreas , Lütz Cornelius , Kräutler Bernhard
Published: July 2012

The disappearance of chlorophyll is a visual sign of fruit ripening. Yet, chlorophyll breakdown in fruit has hardly been explored; its non‐green degradation products are largely unknown. Here we report the analysis and structure elucidation of colorless tetrapyrrolic chlorophyll breakdown products in commercially available, ripening bananas (Musa acuminata, Cavendish cultivar). In banana peels, chlorophyll catabolites were found in an unprecedented structural richness: a variety of new fluorescent chlorophyll catabolites (FCCs) and nonfluorescent chlorophyll catabolites (NCCs) were detected. As a rule, FCCs exist only “fleetingly” and are hard to observe. However, in bananas several of the FCCs (named Mc‐FCCs) were persistent and carried an ester function at the propionate side‐chain. NCCs were less abundant, and exhibited a free propionic acid group, but functional modifications elsewhere. The modifications of NCCs in banana peels were similar to those found in NCCs from senescent leaves. They are presumed to be introduced by enzymatic transformations at the stage of the mostly unobserved, direct FCC‐precursors. The observed divergent functional group characteristics of the Mc‐FCCs versus those of the Mc‐NCCs indicated two major “late” processing lines of chlorophyll breakdown in ripening bananas. The “last common precursor” at the branching point to either the persistent FCCs, or towards the NCCs, was identified as a temporarily abundant “secondary” FCC. The existence of two “downstream” branches of chlorophyll breakdown in banana peels, and the striking accumulation of persistent Mc‐FCCs call for attention as to the still‐elusive biological roles of the resulting colorless linear tetrapyrroles.
Permanent Porous Materials from Discrete Organic Molecules—Towards Ultra‐High Surface Areas
Authors: Mastalerz Michael
Published: July 2012

In recent years, the development of porous materials derived from discrete organic molecules made a substantial progress towards high‐surface‐area materials with distinct properties. One major advantage in comparison to existing, well‐established porous polymers is their solubility, making such compounds potential valuable precursors for “processing porosity”. One important parameter of porous compounds is their specific surface area. The possibilities to reach ultra‐high‐surface‐area materials from this new type of porous compounds are critically discussed.
DNA Binding Studies and Cytotoxicity of a Dinuclear PtIIDiazapyrenium‐Based Metallo‐supramolecular Rectangular Box
Authors: Terenzi Alessio , Ducani Cosimo , Blanco Víctor , Zerzankova Lenka , Westendorf Aron F. , Peinador Carlos , Quintela José M. , Bednarski Patrick J. , Barone Giampaolo , Hannon Michael J.
Published: July 2012

The interaction with native DNA of a 2,7‐diazapyrenium‐based ligand1and its PtIIrectangular metallacycle2is explored through circular and linear dichroism and fluorescence spectroscopies. The metal‐free ligand1binds through intercalation, with a binding constant of approximately 5×105 M−1, whereas the metallacycle2binds and bends the DNA with a binding constant of 7×106 M−1. PCR assays show that metallo‐supramolecular box2interferes with DNA transactions in vitro whereas the intercalator1does not. The metallacycle is active against four human cancer cell lines, with IC50values ranging between 3.1 and 19.2 μMand shows similar levels of efficacy, but a different spectrum of activity, to cisplatin.
ChemInform Abstract: Characterization of the Spin Gap Nature in Na3Cu2SbO6 Using 23Na NMR.
Authors: Kuo C. N. , Jian T. S. , Lue C. S.
Published: July 2012

23Na NMR spectroscopy at temperatures between 4 and 300 K provides clear evidence for the existence of a spin gap in the title compound.
ChemInform Abstract: Synthesis and Characterization of a New Organic—Inorganic Hybrid Zinc Borate: [Zn(dab)0.5(dab′)0.5(B4O6 (OH)2)]·H2O.
Authors: Zhao Pei , Cheng Lin , Yang Guo‐Yu
Published: July 2012

The title compound (dab: 1,4‐diaminobutane) is synthesized by solvothermal reaction of Zn(OH)2 or Zn powder, Al(iPrO)3, H3BO3, H2O, C5H5N, and dab (autoclave, 180 °C, 7 d, 12% yield).
ChemInform Abstract: Bisodium‐Substituted Vanadium Oxide Cluster with Encapsulated [VO4]4‐ Core and Its Electrochemical Property.
Authors: Zhang Lili , Zhang Hengchao , Zhang Weisong , Hu Hailiang , Liu Yang , Kang Zhenhui
Published: July 2012

[Cu(en)2]4 [Na2VV14VIV2 O42(VIVO4)] ·2H2O is synthesized by hydrothermal reaction of NH4VO3, CuSO4, Na3PO4, and en (H2O, autoclave, pH 7.1, 160 °C, 3 d; 56% yield).
ChemInform Abstract: The First Two‐Dimensional Organic—Inorganic Hybrid Constructed by Oxalate‐Bridging Scandium‐Substituted Keggin‐Type Silicotungstate and [Cu(en)2]2+ Coordination Cations.
Authors: Zhang Dongdi , Zhang Shaowei , Ma Pengtao , Wang Jingping , Niu Jingyang
Published: July 2012

[Cu(en)2(H2O)]2{ [Cu(en)2(H2O)]2 [Cu(en)2]2 [(α‐SiW11O39)Sc(H2O)] 2(C2O4)}·8H2O is synthesized by hydrothermal reaction of K4[α‐SiW12O40], ScCl3, CuCl2, H2C2O4, and en (H2O, autoclave, 170 °C, 117 h; 13% yield).
ChemInform Abstract: Novel Synthesis of 1,4‐Phenylene Bridged Bis‐heterocyclic Tropone Compounds.
Authors: Li Yang , Li Feng , Gao Wentao
Published: July 2012

Nucleophilic cyclization reaction of bis(tropolone) derivative (III), which is obtained by Claisen‐Schmidt condensation between terephthalaldehyde (I) and acetyltropolone (II), with bifunctional agents such as substituted phenylhydrazine hydrochlorides (IV) and hydroxylamine hydrochloride gives rise to formation of the desired 1,4‐phenylene bridged bis‐pyrazolo and isoxazole‐fused tropones (V) and (VI).
ChemInform Abstract: Cobalt(II) Phthalocyanine‐Catalyzed Highly Chemoselective Reductive Amination of Carbonyl Compounds in a Green Solvent.
Authors: Kumar Vishal , Sharma Upendra , Verma Praveen K. , Kumar Neeraj , Singh Bikram
Published: July 2012

Aromatic and aliphatic aldehydes and ketones are reductively aminated by primary and secondary amines in ethanol as green solvent.
ChemInform Abstract: Regioselective Cobalt‐Catalyzed Hydrovinylation for the Synthesis of Non‐Conjugated Enones and 1,4‐Diketones.
Authors: Kersten Laura , Hilt Gerhard
Published: July 2012

The 1,4‐hydrovinylation of terminal alkenes or α,ω‐dienes with silyloxybutadiene (II) affords after hydrolysis γ,δ‐unsaturated ketones, which are transformed into the corresponding1,4‐diketones or tetraketones by ozonolysis.
ChemInform Abstract: Organic Base‐Catalyzed Stereodivergent Synthesis of (R)‐ and (S)‐3‐Amino‐4,4,4‐trifluorobutanoic Acids.
Authors: Shibata Norio , Nishimine Takayuki , Shibata Naoyuki , Tokunaga Etsuko , Kawada Kosuke , Kagawa Takumi , Sorochinsky Alexander E. , Soloshonok Vadim A.
Published: July 2012

Both enantiomers of 3‐amino‐4,4,4‐trifluorobutanoic acid (IV) can be prepared, simply by choosing an appropriate organic base catalyst for the Mannich reaction of chiral sulfinylimine (I) and alkyl malonates (II).
ChemInform Abstract: Asymmetric Organocatalytic Formal [2 + 2]‐Cycloadditions via Bifunctional H‐Bond Directing Dienamine Catalysis.
Authors: Albrecht Lukasz , Dickmeiss Gustav , Cruz Acosta Fabio , Rodriguez‐Escrich Carles , Davis Rebecca L. , Joergensen Karl Anker
Published: July 2012

Rational catalyst design supported by computational studies enables the development of a new dual activation mode for the synthesis of fully substituted cyclobutanes with complete diastereo‐ and enantioselectivity.
ChemInform Abstract: Copper(I)—Amine Metallo‐Organocatalyzed Synthesis of Carbo‐ and Heterocyclic Systems.
Authors: Montaignac Benjamin , Oestlund Victor , Vitale Maxime R. , Ratovelomanana‐Vidal Virgnie , Michelet Veronique
Published: July 2012

An efficient and atom economical synthesis of 5‐membered cyclic structures is achieved.
ChemInform Abstract: Lewis Base Catalyzed Enantioselective Additions of an N‐Silyl Vinylketene Imine.
Authors: Denmark Scott E. , Wilson Tyler W.
Published: July 2012

The novel title synthesis uses the stable and easily prepared compound (I).
ChemInform Abstract: Intermolecular Hydroacylation: High Activity Rhodium Catalysts Containing Small‐Bite‐Angle Diphosphine Ligands.
Authors: Chaplin Adrian B. , Hooper Joel F. , Weller Andrew S. , Willis Michael C.
Published: July 2012

Intermolecular hydroacylation of a wide variety of unactivated alkenes, allenes and alkynes with aromatic and aliphatic aldehydes is efficiently catalyzed by rhodium catalysts containing diphosphine ligands with small bite angles.
ChemInform Abstract: Gold‐Catalyzed Amide Synthesis from Aldehydes and Amines in Aqueous Medium.
Authors: Li Gai‐Li , Kung Karen Ka‐Yan , Wong Man‐Kin
Published: July 2012

Title reaction proceeds smoothly in aqueous solution under mild reaction conditions to give a wide variety of aromatic and aliphatic amides (III).
ChemInform Abstract: Iron(III) Catalyzed Synthesis of Unsymmetrical Di‐ and Trisubstituted Ureas — A Variation of Classical Ritter Reaction.
Authors: Basavaprabhu Hosamani , Sureshbabu Vommina V.
Published: July 2012

A mild synthesis of the title compounds is presented from cheap and readily available alcohols and with an inexpensive, nontoxic catalyst.
ChemInform Abstract: Scope of Direct Arylation of Fluorinated Aromatics with Aryl Sulfonates.
Authors: Chang Joyce Wei Wei , Chia Eugene Yurong , Chai Christina Li Lin , Seayad Jayasree
Published: July 2012

An efficient and general method for the title reaction is presented.
ChemInform Abstract: Synthesis of N‐Sulfonylazetidin‐2‐imines via the Copper(I) Oxide Catalyzed Multicomponent Reaction of Alkynes, Sulfonyl Azides and Diimines under Solvent‐Free Conditions.
Authors: Yi Xiaohu , Barry Badru‐Deen , Liao Peiqiu , Bi Xihe
Published: July 2012

Carbodiimides react with various alkynes and azides to give azetidine derivatives.
ChemInform Abstract: Microwave‐Assisted Synthesis of Substituted Naphtho[2,3‐c]furan‐1,3‐dione Derivatives.
Authors: Kawano Tomikazu , Ishikawa Yu , Hatanaka Minoru
Published: July 2012

The self‐condensation of phenylpropiolic acid derivatives (VI) proceeds smoothly in three minutes under microwave irradiation to afford the naphthofurandione derivatives (VII) as single products in moderate to high yields.
ChemInform Abstract: Phosphorothioic Acids and Related Compounds as Surrogates for H2S — Synthesis of Chiral Tetrahydrothiophenes.
Authors: Robertson Forest J. , Wu Jimmy
Published: July 2012

Phosphorothioic esters are used for the synthesis of chiral 2‐aryltetrahydrothiophenes such as (IX).
ChemInform Abstract: A Highly Diastereoselective Three‐Component Tandem 1,4‐Conjugated Addition—Cyclization Reaction to Multisubstituted Pyrrolidines
Authors: Zhang Xia , Ji Jingjing , Zhu Yingguang , Jing Changcheng , Li Ming , Hu Wenhao
Published: July 2012

as a general, efficient, and highly stereoselective approach to pyrrolidines of type (IV) and (VI)
ChemInform Abstract: Construction of Highly Functional α‐Amino Nitriles via a Novel Multicomponent Tandem Organocatalytic Reaction: A Facile Access to α‐Methylene γ‐Lactams.
Authors: Pan Feng , Chen Jian‐Ming , Zhuang Zhe , Fang Yin‐Zhi , Zhang Sean Xiao‐An , Liao Wei‐Wei
Published: July 2012

The first tertiary amine‐catalyzed multicomponent tandem Strecker—allylic‐alkylation (SAA) reaction is developed.
ChemInform Abstract: A Palladium Iodide Catalyzed Carbonylative Approach to Functionalized Pyrrole Derivatives.
Authors: Gabriele Bartolo , Veltri Lucia , Mancuso Raffaella , Salerno Giuseppe , Maggi Sabino , Aresta Brunella Maria
Published: July 2012

A new and convenient method to prepare a number of pyrrole‐3‐carboxylic esters is reported.
ChemInform Abstract: One‐Pot Synthesis of 1‐Alkyl‐1H‐indazoles from 1,1‐Dialkylhydrazones via Aryne Annulation.
Authors: Markina Nataliya A. , Dubrovskiy Anton V. , Larock Richard C.
Published: July 2012

Convenient methods to prepare biologically important target compounds are reported.
ChemInform Abstract: Pd(II)‐Catalyzed Direct C5‐Arylation of Azole‐4‐carboxylates Through Double C—H Bond Cleavage.
Authors: Li Ziyuan , Ma Ling , Xu Jinyi , Kong Lingyi , Wu Xiaoming , Yao Hequan
Published: July 2012

The title reaction provides access to diverse 5‐aryl substituted azole‐4‐carboxylic acid derivatives (III), (VI) and (IX)/(X).
ChemInform Abstract: Copper‐Catalyzed Azide—Alkyne Cycloaddition Reaction in Water Using Cyclodextrin as a Phase Transfer Catalyst.
Authors: Shin Jung‐Ah , Lim Yeong‐Gweon , Lee Kyung‐Hee
Published: July 2012

The method allows an efficient access to a wide range of 1,4‐disubstituted triazoles.
ChemInform Abstract: Generation of Benzofuroxans by Photolysis of Crystalline o‐Nitrophenylazides. A Green Chemistry Reaction.
Authors: Leyva Elisa , Gonzalez‐Balderas Regina M. , de Loera Denisse A. , Jimenez‐Catano Rogelio
Published: July 2012

The reaction produces good yields only with crystalline o‐nitrophenylazides (melting points above 50 °C).
ChemInform Abstract: Discovery of a Phosphine‐Mediated Cycloisomerization of Alkynyl Hemiketals: Access to Spiroketals and Dihydropyrazoles via Tandem Reactions.
Authors: Saha Jaideep , Lorenc Chris , Surana Bikash , Peczuh Mark W.
Published: July 2012

In the presence of PPh3, alkynyl hemiketals and ynones of type (VII) and (IX) undergo novel isomerization to cyclic keto enol ethers.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition of Ethyl Diazoacetate with (E)‐3‐Arylidenechroman‐4‐ones. A New Access to Spirocyclopropane Derivatives.
Authors: Wannassi Nadia , Jelizi Hanene , Rammah Mohamed El Baker , Ciamala Kabula , Knorr Michael , Monnier‐Jobe Karin , Rousselin Yoann , Kubicki Marek M. , Strohmann Carsten
Published: July 2012

Dipolarophiles (I) react with ethyl diazoacetate (II) at the exocyclic double bond of (I), regardless of the electronic nature of the p‐substituents on the aryl group of (I), to provide the single spiro‐compounds (III).
ChemInform Abstract: Microwave‐Assisted, Solvent‐Free, Three‐Component Synthesis of 2,4,6‐Triarylpyridines from Benign Components.
Authors: Zomordbakhsh Shahab , Anaraki‐Ardakani Hossein , Zeeb Mohsen , Sadeghi Mahdi , Mazraeh‐Seffid Manouchehr
Published: July 2012

The microwave assisted reaction between a chalcone, an acetophenone and guanidine as alternative ammonia source provides a simple one‐pot access to 2,4,6‐triarylpyridines (III).
ChemInform Abstract: Photochemically Induced Synthesis of the Topoisomerase I Inhibitors Indeno[1,2‐c]isoquinoline‐5,11‐diones.
Authors: Dubois Melanie , Deniau Eric , Couture Axel , Grandclaudon Pierre
Published: July 2012

A novel synthetic strategy is briefly reported to provide an access to the target compounds (VII), which includes a photoinduced electron cyclization process of functionalized vinylamides (III) as the key step.
ChemInform Abstract: Transition Metal Free Synthesis of Pinacol Alkylboronates from Tosylhydrazones.
Authors: Li Huan , Wang Long , Zhang Yan , Wang Jianbo
Published: July 2012

Various aldehyde‐derived tosylhydrazones react with diboron (II) under metal‐free conditions [cf.
ChemInform Abstract: Asymmetric Synthesis of α‐Amino Boronate Esters via Organocatalytic Pinacolboryl Addition to Tosylaldimines.
Authors: Sole Cristina , Gulyas Henrik , Fernandez Elena
Published: July 2012

Based on preliminary studies it is claimed that an in situ generated MeO‐—bis(pinacolato)diboron adduct combined with the chiral phosphine allows the asymmetric synthesis of title compounds (III) via enantioselective nucleophilic boron addition to tosylaldimines (I).
ChemInform Abstract: An Environment Friendly Preparation of 3‐Bromocamphor and Camphorquinone.
Authors: Kannappan Jayaraman , Bedekar Ashutosh V.
Published: July 2012

A multi‐gram scale preparation of 3‐bromocamphor (II) using KBr / KBrO3 in acidic medium is presented.
ChemInform Abstract: Synthesis of Isoquinoline Alkaloids via Oxidative Amidation/Bischler—Napieralski Reaction.
Authors: Shankar R. , More Satish S. , Madhubabu M. V. , Vembu N. , Kumar U. K. Syam
Published: July 2012

A convenient three‐step sequence is developed which includes preparation of pulcheotine A (Va), thalmicrinone (Vb), and papaveraldine (Vc).
ChemInform Abstract: Antimicrobial Polyacetylenes from Panax ginseng Hairy Root Culture.
Authors: Fukuyama Noriaki , Shibuya Masaaki , Orihara Yutaka
Published: July 2012

The new isolated compounds, namely 1‐hydroxydihydropanaxacol (I) and 17‐hydroxypanaxacol (II), exhibit antimicrobial activity against S.
ChemInform Abstract: Verrulactones A and B, New Inhibitors of Staphylococcus aureus Enoyl‐ACP Reductase Produced by Penicillium verruculosum F375.
Authors: Kim Nyung , Sohn Min‐Jin , Kim Chang‐Jin , Kwon Ho Jeong , Kim Won‐Gon
Published: July 2012

Verrulactones A (I) and B (II), new dimeric compounds of alternariol class, strongly inhibit Staphylococcus aureus enoyl‐ACP reductase and exhibit antibacterial activity against S.
ChemInform Abstract: Catalytic Reactions on Model Gold Surfaces: Effect of Surface Steps and of Surface Doping
Authors: Fajin Jose L. C. , Cordeiro Maria Natalia D. S. , Gomes Jose R. B.
Published: July 2012

Review: 63 refs.
ChemInform Abstract: Applications of Transition Metal Perchlorates in Organic Functional Group Transformations
Authors: Kaur Bhupinder , Parmar Anupama , Kumar Harish
Published: July 2012

Review: 199 refs.
ChemInform Abstract: Conformationally Flexible Chiral Supramolecular Catalysts for Enantioselective Diels—Alder Reactions with Anomalous endo/exo Selectivities
Authors: Hatano Manabu , Ishihara Kazuaki
Published: July 2012

Review: [79 refs.]
ChemInform Abstract: Manganese Compounds in the Catalysis of Organic Reactions
Authors: Khusnutdinov R. I. , Bayguzina A. R. , Dzhemilev U. M.
Published: July 2012

Review: 215 refs.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize.
Authors: Seechurn Carin C. C. Johansson , Kitching Matthew O. , Colacot Thomas J. , Snieckus Victor
Published: July 2012

Review: ca. 300 refs.
ChemInform Abstract: Intermolecular Direct Arylation of Five‐Membered Ring Heterocycles by Nonactivating Aryl Chlorides
Authors: Daugulis O.
Published: July 2012

Review: 15 refs.
ChemInform Abstract: General Methods for the Preparation of 1,2,4,5‐Tetraoxanes — Key Structures for the Development of Peroxidic Antimalarial Agents
Authors: Terent'ev A. O. , Borisov D. A. , Yaremenko I. A.
Published: July 2012

Review: 30 refs.
ChemInform Abstract: Nucleophilic Cyclizations of Enediynes as a Method for Polynuclear Heterocycle Synthesis
Authors: Gulevskaya A. V. , Tyaglivy A. S.
Published: July 2012

Review: 41 refs.
ChemInform Abstract: Acylotropic Intramolecular Rearrangements of Keto Enamines of Benzo[b]‐Anellated Heterocycles
Authors: Minkin V. I. , Bren' V. A. , Dubonosov A. D. , Tsukanov A. V.
Published: July 2012

Review: 24 refs.
ChemInform Abstract: Nitrile Oxide/Alkyne Cycloadditions — A Credible Platform for Synthesis of Bioinspired Molecules by Metal‐Free Molecular Clicking
Authors: Heaney Frances
Published: July 2012

Review: 101 refs.
ChemInform Abstract: Templated Synthesis of Knots and Ravels
Authors: Sauvage Jean‐Pierre , Amabilino David B.
Published: July 2012

Review: 69 refs.
ChemInform Abstract: Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
Authors: Schmidt Arndt W. , Reddy Kethiri R. , Knoelker Hans‐Joachim
Published: July 2012

Review: 896 refs.
ChemInform Abstract: Organometallic Compounds: An Opportunity for Chemical Biology?
Authors: Patra Malay , Gasser Gilles
Published: July 2012

Review: 189 refs.
ChemInform Abstract: Enhanced Solid Phase PCR for Increased Loading of Amplicon onto Solid Support
Authors: Park Daniel J.
Published: July 2012

Review: 14 refs.
Acid/Alkali Gated Photochromism of Diarylethenes with Quinoline Derivatives
Authors: Song Bo , Li Haixia , Yang Lin , Zhang Fushi , Xiang Junhui
Published: July 2012

Three new diarylethenes 1–3 combined with quinoline derivatives have been synthesized. Through controlled chemical condition of deprotonation/protonation, they presented some new irreversible photochromic phenomenons under UV/Vis light irradiation in chloroform solution. It was found that 1–3 had well photoisomerization upon UV/Vis light irradiation in neutral chloroform solution. Addition of acid to the solution of the ring‐opening isomers of 1–3 produced 1oa–3oa, which performed reversible photochromic behavior under UV/Vis light irradiation and reversed back to 1–3 under neutralizing with adding lewis base. However, addtion of base to neutral soluton of the ring‐opening isomers of 1–3 produced 1ob–3ob, which could not change to the deprotonated ring‐closing isomers under UV light irradiation.
Emergency Management of Bleeding Associated With Old and New Oral Anticoagulants
Authors: Frank Peacock W. , Gearhart Michelle M. , Mills Roger M.
Published: July 2012

As major prescribers of oral anticoagulants, cardiologists must be familiar with strategies to manage bleeding, the principal complication associated with all anticoagulants, and to reverse anticoagulant effects in acute‐care settings. The purpose of this manuscript is to review currently available information regarding dabigatran and rivaroxaban, the 2 novel oral anticoagulants approved to date in the United States. Further, we suggest reasonable interventions for the clinician faced with a patient who suffers a major bleeding event while receiving one of these agents. Data sources were peer‐reviewed publications, US Food and Drug Administration documents in the public domain, and approved US prescribing information for dabigatran (Pradaxa) and rivaroxaban (Xarelto). Strategies for management of bleeding and reversal of anticoagulant effects from warfarin include vitamin K, fresh frozen plasma, and prothrombin complex concentrates. For rivaroxaban and dabigatran, appropriate therapies include support and observation, which are likely to be effective for the majority of patients because of the short half‐lives of these agents. In severe life‐threatening hemorrhage, clotting‐factor substitutes may be appropriate in certain situations. Validated protocols specific to each agent remain to be developed. Clin. Cardiol. 2012 doi: 10.1002/clc.22037

Editorial support for this paper was provided by Janssen Scientific Affairs, LLC. W.F.P. has received research grants (>$10 000) from Abbott, Alere, Baxter, Brahms, Novartis, and The Medicines Company. He has been a consultant (<$10 000) for Abbott, Alere, Eli Lilly, and The Medicines Company; served on the speaker's bureau (<$10 000) for Abbott and Alere; and has ownership interest (<$10 000) in Comprehensive Research Associates LLC, Vital Sensors, and Emergencies in Medicine LLC. M.M.G and R.M.M. are full‐time employees of Janssen Scientific Affairs, LLC. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c‐FLIP in Cancer Cells
Authors: Leal Ana S. , Wang Rui , Salvador Jorge A. R. , Jing Yongkui
Published: July 2012

A series of ursolic acid ((1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)‐10‐hydroxy‐1,2,6a,6b,9,9,12a‐heptamethyl‐2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b‐tetradecahydro‐1H‐picene‐4a‐carboxylic acid) derivatives with a 12‐fluoro‐13,28β‐lactone moiety were synthesized using the electrophilic fluorination reagent Selectfluor. The antiproliferative effects of these novel compounds were evaluated in AsPC‐1 pancreatic cancer cells, and the structure–activity relationships (SARs) were evaluated. Of the compounds synthesized, ursolic acid derivatives carrying a heterocyclic ring, such as imidazole or methylimidazole, and cyanoenones were among the more potent inhibitors of AsPC‐1 pancreatic cancer cell growth. 2‐Cyano‐3‐oxo‐12α‐fluoro‐urs‐1‐en‐13,28β‐olide, compound 20, was the most effective inhibitor with IC50 values of 0.7, 0.9 and 1.8 μM in pancreatic cancer cell lines AsPC‐1, MIA PaCa‐2 and PANC‐1, respectively. This compound also exhibited better antiproliferative activities against breast (MCF7), prostate (PC‐3), hepatocellular (Hep G2) and lung (A549) cancer cell lines, with IC50 values lower than 1 μM. The mechanism of action by which these compounds exert their biological effect was evaluated in AsPC‐1 cells using the most potent inhibitor synthesized, compound 20. At 1 μM, the cell cycle arrested at the G1 phase with upregulation of p21waf1. Apoptosis was induced at an inhibitor concentration of 8 μM with upregulation of NOXA and downregulation of c‐FLIP. These data indicate that fluorolactone derivatives of ursolic acid have improved antiproliferative activity, acting through arrest of the cell cycle and induction of apoptosis.
Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma
Authors: Cao Yun , Zhang Zhi‐Ling , Zhou Ming , Elson Paul , Rini Brian , Aydin Hakan , Feenstra Kristin , Tan Min‐Han , Berghuis Bree , Tabbey Rebeka , Resau James H. , Zhou Fang‐Jian , Teh Bin Tean , Qian Chao‐Nan
Published: July 2012

BACKGROUND.

The objective of this study was to evaluate the effect of pericyte coverage (PC) of differentiated tumor microvessels on the prognosis of patients with clear cell renal cell carcinoma (CCRCC).

METHODS.

Samples from 2 cohorts of patients with CCRCC (101 Asian patients and 524 US patients) were prepared using 2 different histologic approaches: routine sectioning versus tissue microarray. Then, the samples were immunohistochemically doubled‐stained for a pericyte marker (alpha smooth muscle actin [α‐SMA]) and a differentiated vessel marker (cluster of differentiation 34 [CD34]), followed by multispectral image capturing and computerized image analyses to quantify the microvessel density (MVD) and the PC of differentiated vessels. The correlations of PC and the MVD:PC ratio with clinicopathologic characteristics were analyzed.

RESULTS.

There was an inverse correlation between differentiated MVD and PC. Higher PC correlated with more aggressive clinicopathologic characteristics of CCRCC in both cohorts, including more advanced T‐classification, higher pathologic grades, and the occurrence of tumor necrosis. The MVD:PC ratio was an independent favorable prognostic factor for overall and recurrence‐free survival in the Asian cohort and for recurrence‐free survival in the US cohort. PC also was an independent prognostic factor, with higher PC predicting a poorer outcome. The combination of PC and MVD was better at distinguishing the outcome of patients with CCRCC. PC combined with differentiated MVD or with the MVD:PC ratio provided additional, independent prognostic information to the Leibovich risk model, and that information was used to generate improved risk models.

CONCLUSIONS.

The authors consistently observed that higher PC was correlated with more aggressive clinicopathologic characteristics. PC was an independent unfavorable prognostic factor. The authors concluded that pericytes should be considered for therapeutic targeting. Cancer 2013. © 2012 American Cancer Society.
Adjuvant chemotherapy for stage III colon cancer in the oldest old
Authors: Abraham Anasooya , Habermann Elizabeth B. , Rothenberger David A. , Kwaan Mary , Weinberg Armin D. , Parsons Helen M. , Gupta Pankaj , Al‐Refaie Waddah B.
Published: July 2012

BACKGROUND:

Randomized trials demonstrating the benefits of chemotherapy in patients with American Joint Committee on Cancer stage III colon cancer underrepresent persons aged ≥ 75 years. The generalizability of these studies to a growing elderly population remains unknown.

METHODS:

Using the California Cancer Registry for 1994 through 2008, the authors conducted a population‐based study of postcolectomy patients aged 50 years to 94 years with stage III (N1M0) colon adenocarcinoma. A 2‐sided chi‐square test and Cochran‐Armitage test for trend were used to compare patient and tumor characteristics associated with receipt of chemotherapy across age groups. Multivariate regression was used to assess the association between older age and receipt of chemotherapy. Kaplan‐Meier methods and Cox proportional hazards modeling were used to evaluate the association between chemotherapy and mortality, with propensity score adjustment.

RESULTS:

Approximately 44% (12,382 patients) of the study cohort was aged ≥ 75 years. Persons aged ≥ 75 years were found to be less likely to have received adjuvant chemotherapy than those aged < 75 years (30% vs 68% in patients aged 50 years‐74 years; P < .0001). On multivariate analysis, patients aged 75 years to 84 years were 13 times less likely, and those aged 85 years to 94 years were 24 times less likely, to have received chemotherapy as patients aged 50 years to 64 years. Nevertheless, age‐stratified multivariate survival analyses indicated that chemotherapy provided comparable mortality reduction across age groups.

CONCLUSIONS:

The percentage of persons aged ≥ 75 years receiving adjuvant chemotherapy remains low despite demonstrated survival benefits. These findings deserve attention within the context of a patient's life expectancy, underlying comorbidities, and performance status, as well as clinician bias. The results of the current study support the call for phase II/III studies assessing the toxicities and benefits of adjuvant chemotherapy for the treatment of stage III colon cancer in the elderly. Cancer 2013. © 2012 American Cancer Society
From Molecular Gallium and Indium Siloxide Precursors to Amorphous Semiconducting Transparent Oxide Layers for Applications in Thin‐Film Field‐Effect Transistors
Authors: Samedov Kerim , Aksu Yilmaz , Driess Matthias
Published: July 2012

The syntheses, structural characterization, and thermal degradation of a series of the new indium and gallium siloxide dimers [{Me2In(OSiEt3)}2] (1), [{Me2Ga(OSiEt3)}2] (2), [{Me2In(OSi(OtBu)3)}2] (3), [{Me2Ga(OSi(OtBu)3)}2] (4), and In[OSi(OtBu)3)] (5) is reported. Compounds 1–4 are readily accessible by facile Brönsted reaction of InMe3 or GaMe3 with the corresponding silanols Et3SiOH and (tBuO)3SiOH, respectively. Compound 5 could be obtained by analogous protolysis of [In{N(SiMe3)2}3] with an excess amount of (tBuO)3SiOH. The suitability of 1–5 to serve as molecular precursors for low‐temperature synthesis of amorphous indium and gallium oxide for electronic applications was probed. Thus their thermal degradation was studied by Thermogravimetric/differential thermogravimetry analysis (TGA/DTG). Compounds 1–4 were decomposed under dry synthetic air (20 % O2, 80 % N2) at low temperature to yield amorphous indium oxide and gallium oxide particles, respectively. In contrast, thermal degradation of 5 affords amorphous indium silicate. All of these products were analyzed by multiple techniques including powder X‐ray diffraction analysis (PXRD), transmission electron microscopy (TEM), and energy dispersive X‐ray spectroscopy (EDX). Thin‐film field‐effect transistors (FETs) could be fabricated through spin‐coating of silicon‐wafers with solutions of 1 in toluene and subsequent calcination under dry synthetic air at 350 °C. These films exhibit very good FET performance with a field‐effect mobility of 3.0×10−1 cm2 V−1 s and an on/off current ratio of 108.
Functionalized Dithienylthiazolo[5,4‐d]thiazoles For Solution‐Processable Organic Field‐Effect Transistors
Authors: Van Mierloo Sarah , Vasseur Karolien , Van den Brande Niko , Boyukbayram Ayse E. , Ruttens Bart , Rodriguez Silvio D. , Botek Edith , Liégeois Vincent , D'Haen Jan , Adriaensens Peter J. , Heremans Paul , Champagne Benoît , Van Assche Guy , Lutsen Laurence , Vanderzande Dirk J. , Maes Wouter
Published: July 2012

A series of 5′‐aryl‐substituted 2,5‐bis(3′‐hexylthiophen‐2′‐yl)thiazolo[5,4‐d]thiazole derivatives was synthesized and these expanded semiconductors were investigated as active materials for solution‐processable organic field‐effect transistors. Field‐effect mobilities of up to 10−3 cm2 V−1 s−1 were obtained, representing the first reasonable FET behavior for highly soluble thiazolo[5,4‐d]thiazole‐based small organic compounds suitable for printable electronics. Thermal and electrooptical material properties were studied by thermogravimetric analysis, differential scanning calorimetry, cyclic voltammetry, and UV/Vis spectroscopy. Trends in thermal and optical data were supported by (time‐dependent) density functional theory calculations. Additional X‐ray diffraction, atomic force microscopy, and scanning electron microscopy studies provided insight in the relationship between the molecular structures, film morphologies, and FET performances. The fibrillar microcrystalline structure observed for the best‐performing thienyl‐substituted material was linked to the high mobility.
Electrodes of Poly(N‐methyl pyrrole)/Au and Poly(m‐aminobenzene sulfonic acid)‐Functionalized Multiwalled Carbon Nanotubes for Supercapacitor Applications
Authors: Narsimha Reddy B. , Billa Naresh , Deepa Melepurath
Published: July 2012

An assembly of poly(N‐methyl pyrrole) (PMP) doped with poly(3‐styrene sulfonate) with embedded Au nanoparticles (PMP/Au) was grown by electropolymerization of the monomer (MP) followed by adsorption of a Au colloid. Multiwalled carbon nanotubes were functionalized with poly(m‐aminobenzene sulfonic acid) (MWCNT/PABS) and deposited electrophoretically over conducting substrates. X‐ray diffraction (XRD) and Raman studies confirmed the successful functionalization of the MWCNTs by PABS. A new asymmetric supercapacitor design incorporating PMP/Au and MWCNT/PABS as electrodes was implemented for the first time, and the cell delivered a reversible specific capacitance of 967 F g−1 and a maximum energy density of 174 Wh Kg−1, which was superior to a PMP‐MWCNT/PABS cell (167 F g−1) and higher than many reported capacitances of poly(pyrrole)‐based supercapacitors. The PMP/Au electrode outperformed pristine PMP, graphite, and MWCNT/PABS electrodes in a study of different symmetric and asymmetric cells employing these electrodes. Scanning spreading resistance microscopy (SSRM) and conducting atomic force microscopy (C‐AFM) showed a lower spreading resistance and a larger nanoscale electronic conductivity for the PMP/Au electrode than for the pristine PMP electrode; these attributes allow unhindered charge transport both in the radial direction and across the cross‐section of the PMP/Au electrode. The facile electron propagation in the PMP/Au electrode, enabled by the presence of localized conducting domains of Au nanoparticles implanted in the PMP electrode, effectively translates into an enhanced specific capacitance of PMP/Au‐based cells relative to PMP. The results demonstrate that asymmetrically designed cells offer an exciting way to boost the overall performance of supercapacitors.
Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins
Authors: Liao Hsin‐Kai , Wang Ying , Noack Watt Kristin E. , Wen Qin , Breitbach Justin , Kemmet Chelsy K. , Clark Karl J. , Ekker Stephen C. , Essner Jeffrey J. , McGrail Maura
Published: July 2012

COVER PHOTOGRAPH: Confocal image of live 36 hpf double transgenic appais22Gt; Tg(flk1:moesin‐gfp)is1 embryo. The image shows accumulation of appaRFP fusion proteins specifically at the veinous vessels in the head and anterior region of the trunk, including the midcerebral and common cardinal veins. Arteries and veins are visualized by expression of moesin:GFP throughout all endothelial cells of the vasculature. From Liao et al., Developmental Dynamics 241:415–425, 2012.
Impaired expression of CD26 compromises T‐cell recruitment in human visceral leishmaniasis
Authors: Rai Ambak K. , Thakur Chandreshwar P. , Kumar Prabin , Mitra Dipendra K.
Published: July 2012

An inefficient Th1 response, coupled with skewed Th2 cytokine production, has been implicated to increase susceptibility to visceral leishmaniasis (VL) infection. The expression of the dipeptidyl peptidase Cd26 by polarized Th1 activates a chemokine cascade that recruits Th1 recruitment to the pathologic site. Here, we studied 42 patients with confirmed VL (mean age 24.80 ± 16.26 years; range 3–70 years; 25 males and 17 females), 30 endemic controls, and 10 nonendemic controls. We observed a decrease in constitutive and antigen‐induced expression of CD26 on the T cells of VL patients. Soluble CD26 (sCD26) levels in serum and BM were also found to be significantly lower in VL patients. Following successful therapy, increased sCD26 expression was observed. Tuberculosis pleural effusion derived CCR5+CXCR3+ effector T cells showed enhanced chemokine‐driven migration in the presence of posttreatment BM aspirate containing high levels of sCD26. Moreover, T‐cell migration could be inhibited by blocking RANTES, IP‐10, and CD26 signaling from the posttreatment aspirate with Ab. Our results indicate that, in VL patients, impaired expression and secretion of CD26 compromises chemokine activation and thus T‐cell recruitment, eventually resulting in a deficient state of local immunity at pathologic sites.
Mercury‐Sequestering Pseudopeptides with a Tris(cysteine) Environment in Water
Authors: Pujol Anaïs M. , Lebrun Colette , Gateau Christelle , Manceau Alain , Delangle Pascale
Published: July 2012

The three pseudopeptides L1–3 having three converging cysteine arms anchored on a nitrilotriacetic acid scaffold, are demonstrated to be efficient sulfur‐based HgII chelating agents. The three ligands differ by the nature of the carbonyl group of the cysteine moieties, ester, amide, and carboxylate for L1, L2, and L3, respectively. The coordination chemistry of the mercury thiolate complexes was characterized in water by acid–base titration and several spectroscopic methods, including UV, 1H, and 199Hg NMR spectroscopy and Hg‐LIII EXAFS. At alkaline pH, they form monometallic complexes with typical signatures of a trigonal HgS3 coordination site, which is uncommon, as HgII usually prefers a coordination number of two. The digonal HgS2 structure is formed at acidic pH, where one cysteine group is protonated (HgLH complex). EXAFS spectra at liquid He temperature and alkaline pH are nearly identical for the three HgL complexes. Their analysis reveals an asymmetrical HgS3 binding environment with three S atoms at 2.38, 2.51, and 2.67 Å. This suggests that the C3‐symmetrical species detected by 1H NMR spectroscopic analysis at 298 K are averages of nonsymmetrical complexes that rapidly equilibrate on the NMR time‐scale at ambient temperature. At acidic pH, HgII is coordinated in a linear configuration to the two sulfur atoms from the thiolate groups at a distance of 2.36 Å, and in a T‐shaped geometry to the third sulfur atoms from the protonated cysteine at 3.07 Å. The three pseudopeptides have high affinities for HgII and are interesting alternatives for the design of efficient water‐soluble mercury‐sequestering agents that favor an uncommon tris(thiolato)mercury environment.
Effective Palladium‐Catalyzed Synthesis of Triarylethene‐Based Molecules in Aqueous Solution
Authors: Zhu Yan , Sun Peng , Yang Hailong , Lu Linhua , Yan Hong , Creus Marc , Mao Jincheng
Published: July 2012

Highly effective and selective Pd‐catalyzed coupling reactions of 1,1‐dibromo‐1‐alkenes with various arylboronic acids have been performed in aqueous solution under mild conditions. The method is simple, economic, and practical for the synthesis of triarylethene‐based compounds.