bluuebunny/crossref_metadata_2025 huggingface dataset:
Judicial Protection of Social Rights and Respect for Human Dignity
Authors: Savchyn Mykhailo
Published: December 2023

he article analyzes the idea of protection of social rights based on the universal nature of human rights as the obligation of the state to protect certain goods, in particular, the distribution of goods in the case of unequal economic status of individuals or the occurrence of life circumstances beyond the individual's will. The protection of social rights is also seen through the principle of ubi jus ibi remedium, the fair distribution of goods on the basis of an equal scale of rights and freedoms.

The purpose of the study is to reveal the nature of social protection through the concept of guarantee of rights based on respect for human dignity. In particular, the author reveals the nature of social rights through the duty to protect the state, which is discussed through human dignity, freedom and equality. The author analyzes the jurisprudence of the Constitutional Court of Ukraine on the content of the state's obligation to ensure and protect social rights in the light of the approaches of the European Court of Human Rights. The author demonstrates the approach of the Supreme Court to the constitutional and administrative provision of social rights on the example of cases on social rights. The author formulates a holistic vision of social rights enforcement given the limited resources in the context of war and post-war renewal of Ukraine.

Key words: administrative proceedings, constitutional jurisprudence, duty to protect, human dignity, judicial protection, social rights, the very essence of the right.
Administrative court: constitutional status, task and place in the judicial system of Ukraine
Authors: Bernaziuk Jan
Published: December 2023

The article is devoted to the disclosure of the constitutional and legal status of the administrative court in the judicial system of Ukraine. The tasks and place of the administrative court in the judicial system of Ukraine are determined. The opinion that the main purpose of administrative courts is prevention and effective resolution of conflicts between a person and the state is substantiated. It is argued that the activity of administrative courts is an important guarantee of harmonious relations in society as a whole, trust in the state and its institutions, as well as the progressive development of each person as a part of society and the prevention of the appearance of internal and external threats to such a society.

The author outlines the purpose of the administrative court. It has been proven that the main purpose of administrative proceedings is to protect the violated right of the relevant person, to correct a possible mistake of the subject of power, to instruct the subject of power on the impossibility of committing such a mistake in the future.

The peculiarities and advantages of administrative proceedings in comparison with economic and civil proceedings are clarified. It is substantiated that the main practical difference in the resolution of public-law disputes by administrative courts is the presumption of legality of a person's claims (putting the burden of proof on the subject of power) and the presumption of proof of the subject of power according to the standard «beyond reasonable doubt».

The author defines the legal nature of the interrelationship between administrative courts and the Constitutional Court of Ukraine. It was found out that such interconnection is due to their special place in the system of institutional provision of the rule of law (rule of law), since these two types of judicial proceedings are designed to ensure the consistent nature of the entire legal system in the conditions of the coexistence of conflicting norms, thanks to which the effectiveness of the rule of law (rule of law) is achieved), i.e. its effectiveness.

Key words: administrative court, public legal dispute, jurisdiction, access to court, effective protection, public (public) interests, national security, principles of equality and competition, discretion.
Differentiation of grounds for disciplinary liability of judges
Authors: Melnik Oleksiі , Rybalko Volodymyr
Published: December 2023

The article focuses on the distinction between the grounds for disciplinary liability of judges. It is noted that the main reason for different qualification of similar violations of judges is a large number of evaluative concepts among the grounds for disciplinary liability. The corpus delicti of judicial misconduct have a large number of similar features in terms of content, and therefore the practice of their application is complex and controversial. The issue of distinguishing between the elements of disciplinary misconduct requires special attention, since the severity of the type of penalty chosen by a judge depends on the accuracy of the disciplinary and legal qualification. The author emphasizes that the reasons for the problem of distinguishing the grounds for disciplinary liability of judges are their broad formulations at the legislative level, a large number of evaluative concepts and an increase in the number of related corpus delicti over the past decades. Examples from disciplinary practice show that there are no uniform approaches to the qualification of disciplinary offenses related to procedural violations of judges in the administration of justice. In some cases, similar procedural violations are qualified only on one ground, in some cases – on another ground, and in others – on several grounds.

Different disciplinary and legal qualifications of similar judicial misconduct lead to different disciplinary sanctions. The author emphasizes that it is important not only to identify consistent legal positions on the disciplinary and legal qualification of judicial misconduct, but also to offer future disciplinary inspectors a certain standard algorithm of actions and methodology for qualifying judicial misconduct during an inspection. In order to avoid criticism and accusations of double standards, it is important to develop and put them into practice.

Key words: disciplinary liability of judges, grounds for disciplinary liability, disciplinary offenses, disciplinary sanctions, qualification of violations..
The role of state authorities in ensuring human rights during restrictions in the pandemic period: a comparative analysis of the experience of foreign countries
Authors: Voloshyn Yuriy , Holovatenko Marina
Published: December 2023

The Covid-19 pandemic, which began in 2019, has become the main cause of global crises in modern history, causing serious concerns for the health and lives of people, as well as for the functioning of society. One of the most difficult aspects of fighting the pandemic has been finding a balance between protecting public health and preserving the rights and freedoms of citizens. This article examines the experience of foreign state authorities in implementing mechanisms for restricting human and citizen rights and freedoms during the pandemic and quarantine measures.

Attempts to control the spread of Covid-19 have contributed to the introduction of various restrictions and quarantine measures in many countries around the world. However, these measures became the object of debate and criticism, after which they affected a number of basic rights and freedoms of citizens, such as the right to freedom of movement, the right to work, the right to education, freedom of information and others.

One of the main conclusions that can be drawn from the experience of foreign countries is the importance of proportionality and limitation of restrictions introduced in connection with the pandemic. Many countries have tried to maintain a balance between restrictions and the rights of citizens, recognizing that such restrictions must be necessary, proportionate and limited in time and scope. Some countries have successfully implemented mechanisms for periodic review and analysis of restrictions to ensure their adequacy and necessity.

An important aspect of the experience of foreign countries was attention to the protection of the basic rights and freedoms of citizens. Many countries took human rights into account when developing and implementing strategies to combat the pandemic. For example, the right to health care and the right to access information about the pandemic were recognized as key components of the fight against the crisis.

Public participation also played an important role in the experience of foreign countries. Some countries involved non-governmental organizations and citizens in decision-making on restrictions, which contributed to greater legitimacy and respect for citizens' rights.

In addition, the experience of foreign countries has shown the importance of developing strategies for exiting quarantine measures. The gradual relaxation of restrictions and the establishment of clear criteria for this were key to successful adaptation to the new reality.

Key words: рandemic, state authorities, Covid-19, restrictions on the rights and freedoms of citizens, human rights, quarantine measures.
International Legal Foundations Of Compliance With Nuclear Non-Proliferation Guarantees
Authors: Les Iryna
Published: December 2023

One of the results of the development of international relations in the second half of the current century was the transformation of nuclear weapons directly into a factor of world politics, which hangs over the entire global security system even in the conditions of the “post-confrontational era”. This is not the inertia of the philosophy of containment, as the world in the 1980s and 1990s proved its flexibility and even readiness for transformations by the ever-increasing susceptibility of international relations to scientific and technical influence. The rapid development of atomic energy, despite a number of man-made disasters (from Trimayland to Chernobyl), continues, and the diversity of research in this field is combined with the number of countries interested in the scientific development of this field. Therefore, guarantees of the exclusively peaceful orientation of the energy programs of non-nuclear states, a legally established and effective ban on the production of nuclear weapons best correspond to modern concepts of maintaining stability in certain regions and the world as a whole.

However, the regime of non-proliferation of nuclear weapons, although it limited the hyperbolization of the nuclear factor in a certain historical segment, could not fully fulfill its second task of ranking states into only two groups - nuclear and non-nuclear. Outside of this dual, simplified scheme of political regulation of conflicting interests, a risk group has emerged, consisting of countries with a vague status of “near-threshold”. This happened not only because the nuclear states created a cult of nuclear weapons, but also because the logic of scientific and technological progress led to this, which was distorted in the prism of rivalry between states, especially at the regional level. First of all, the process of industrial-type countries approaching the nuclear threshold, which the block of post-industrial societies is trying to isolate from them, is absolutely inevitable from the point of view of science and technology. This does not mean equalizing the levels of development, which would create a favorable foundation, and then objective prerequisites for solving a whole series of contradictions in the system of international relations and, perhaps, removing the nuclear problem itself from the agenda. On the contrary, the configuration of inequality remained the same and only moved, pulling the locomotive of technical progress along the rails of global economic relations, to the zone of nuclear coordinates.

Key words: IAEA, Treaty on the Non-Proliferation of Nuclear Weapons, nuclear weapons, nuclear materials, General Assembly of the United Nations.
Fırat, F. Berrak. (2023). Sağır Sporlarında Antrenör-Sporcu İlişkisi ve İşaret Dili Çevirmeninin Rolü. Ankara: Gazi Kitabevi, 139 s. ISBN: 978-625-365-244-9
Authors: ORAL Zeynep
Published: December 2023

Bu çalışma, Sağır sporlarında Sağır sporcu ile antrenör arasında iletişimde köprü görevi gören işaret dili çevirmenlerini, çeviribilim, spor bilimleri ve davranış bilimleri ışığında ele alarak alana katkı sağlayan ve farklı disiplinleri birleştiren nitelikli bir araştırma kapsamındadır. Türkiye’de bir ilk olan çalışma somut çıktılardan hareketle Sağır Sporlarında önemli bir aktör olan işaret dili çevirmenliği mesleğinin alandaki önemini, yetkinlikleri ve meslek zorluklarını ortaya koyarak, bu çerçevede öneriler ve iyi uygulamalar sunmaktadır.
Stylistic/Textual Analysis of Narrative Techniques in Ngugi Wa Thiong’o’s a Grain of Wheat
Authors: Ohia Ben-Fred
Published: December 2023

In A Grain of Wheat, Ngugi Wa Thiong’o demonstrates his mastery of language for both narration and description. In the plot, while telling the story, he provides a vivid description of the social and natural settings in which the action is taking place. He adopts the use of omniscient narrator technique as an objective technique that makes it possible to probe the innermost depths of the characters and determine their psychological and emotional states, especially in the protest against the whiteman’s domination of the land. Occasionally, he attempts to illustrate the ongoing action with a corresponding visual symbolism or external imagery starting from the title of the novel – A Grain of Wheat and the character – Kihika respectively. This paper examines stylistic/textual analysis of narrative techniques of Ngugi’s style of narrative in A Grain of Wheat. The purpose of this study is to analyse the colonial influences on the Kenyan environment using the post-colonial theory and employing the qualitative method to gather data as regards the use of narrative techniques in the novel. The findings are that the source of environmental degradation and marginalisation of the natives in the novel warranted the use of narrative techniques, especially symbolism and visual imagery as indicated and perfected by the author in A Grain of Wheat. His use of flashback techniques is to give the reader insight into the life and activities in Kenya. Therefore, this paper recommends the use of narrative techniques by authors as part of the thematic expressions of their works.
Use of Instructional Videos to Augment the Teaching of ICT Practical Sessions in the midst of Higher Students Enrollment
Authors: Manu Jacob
Published: December 2023

The current study looked at how instructional videos were created and used to augment the practical teaching and learning of information and communication technology (ICT) course. With a sample size of 1620 students, the researcher created customized short instructional videos on the different topics on the course outline and shared videos on the platform of the students in the Fall of 2021/2022 school year. The researcher found evidence that the use of the instructional videos was helpful in the practical lessons. Second, participants indicated that using the instructional videos was their first time in this university. Finally, the participants expressed their desire to use the instructional videos in the near future as well as recommend to their peers in other programmes. Implications for practice are discussed.
Kitap İncelemesi: Monitoring the Sustainable Development of a Seaside Tourist Destination (Deniz Kenarı Turist Destinasyonlarının Sürdürülebilir Gelişiminin İzlenmesi
Authors: KİPER Vahit Oğuz
Published: December 2023

"Deniz Kenarı Turist Destinasyonlarının Sürdürülebilir Gelişiminin İzlenmesi" başlıklı bu kitap, turizm sektörünün temel bir unsuru olan destinasyon gelişiminin sürdürülebilirlik perspektifinden nasıl ele alınabileceğini kapsamlı bir şekilde inceliyor. Güncel alanyazın ve örnek olaylarla desteklenen kitap, turizm destinasyonlarının evrimsel süreçlerini, sürdürülebilirlik ilkelerini ve izleme yöntemlerini içeren çok yönlü bir çerçeve sunuyor. Bölümler arasında modern turizm konseptinin ele alındığı ilk bölümden başlayarak, turist destinasyonlarının sürdürülebilir gelişimi, izlenmesi ve değerlendirilmesi yöntemlerine uzanan bir yolculuk sunuyor. Farklı yazarlar veya yazar gruplarının katkılarıyla hazırlanan bu kitap, sürdürülebilir turizm yönetimi konusunda akademik bir rehberlik sunmanın yanı sıra, sektör profesyonellerine de pratik bir bakış açısı sunmayı amaçlıyor.
Perencanaan Produksi AMDK 240 ML dengan Metode Trend Liniear
Authors: Wiyono Aprili , Andriyas Puji Ari
Published: December 2023

PT. Amanah Insanillahia is a company engaged in the field of bottled drinking water (AMDK). PT Amanah Insanillahia produces bottled drinking water under the AMIA brand. In its development, PT Amanah Insanillahia experienced obstacles in certain sectors, for example companies that produce goods without considering market demand, resulting in increased storage costs and also old goods stored will expire. Therefore, to reduce excess storage at PT Amanah Insanillahia, through the discussion in this practical work report, it is necessary to analyse production forecasting using the linear trend method. To meet market needs, the company must know how much sales forecasting will come so that the company can produce goods in accordance with predicted sales. Sales forecasting can help companies minimise costs in producing goods produced, because by knowing some sales in the next period, companies can produce goods in moderation.With the linear trend method.
Pengendalian Persediaan Batu Splite PT. Lutvindo Wijaya Perkasa dengan Metode Continuous Review System
Authors: Yul Faradila Ananda , Dini Dwi Meliani Putri  , Hendri Ali Ardi
Published: December 2023

Pada divisi Stone Crusher di PT. Lutvindo Wijaya Perkasa terjadi kondisi jumlah persediaan hasil produksi batu Splite yang sering kekurangan ataupun kelebihan karena batu gunung selalu melakukan aktivitas produksi setiap hari namun pemakaian pada aspal dan beton menggunakan sistem make to order, sehingga ketika pemakaian batu banyak, bisa mengakibatkan kekurangan. Dari pemakaian yang terjadi secara musiman, maka peneliti akan menentukan persediaan dengan metode Continuous Review System dengan model Q untuk menentukan jumlah biaya yang harus dikeluarkan agar lebih efisien. Berdasarkan hasil perhitungan menggunakan metode CRS dengan model Q, jumlah pemesanan optimal batu Splite 1/2 = 219 Ton, Safety Stock (SS) = 0, Reorder Point (r) = 4,313 Ton, dan total biaya persediaan = Rp. 15.106.391.598
Desain Ulang Meja Baca Al-Quran Ergonomis di Pondok Pesantren Al-muayyad Surakarta
Authors: Muflikhul Amin  , Firdaus Ashari
Published: December 2023

Pesantren merupakan lembaga pendidikan tertua, sudah ada sejak sebelum zaman kemerdekaan. Kegiatan yang dilakukan dalam pesantren diantaranya sholat wajib berjamaah, puasa wajib maupun sunah, mempelajari kitab kuning, dan membaca Al-Quran. Santri di pondok pesantren Al-muaayad mengalami kendala pada saat menggunakan meja yaitu desain terlalu pendek dan meja susah dibawa untuk berpindah-pindah. Dengan mengidentifikasi permaslahan yang ada, maka dilakukan perbaikan desain meja dengan memperhatikan aspek antropomeri agar lebih ergonomis dan TRIZ untuk menndapatkan solusi spesifik dalam perbaikan desian. Dari hasil peperhitungan dan solusi spesifik TRIZ diusulkan tiga desain dengan dimensi tinggi penyangga yang paling dekat 40 cm pangang papan 40 cm dan lebar papan 32cm, dan sudut kemiringan papan 30%. Adapun usulan yang terpilih dari ketiga usulan yaitu desain usulan ketiga.
Analisis Efektivitas Gas Turbine Generator pada PT Mitra Energi Batam
Authors: Nur Azila  , Elsya Paskaria Loyda Tarigan
Published: December 2023

PT Mitra Energi Batam is one of the Gas Power Plants (PLTG) and regulates the electricity supply of Batam city with PT PLN-Batam. According to the tabulation of PT Mitra Energi Batam's production data from September 2022 to September 2023, the rolls-royce Gas Turbine Generator production engine has a downtime value of 805.60 hours. The purpose of the study is to find out the factors that cause high downtime and know how to minimize it. Using the proposed Overall Equipment Effectiveness method as a way to measure Losses due to production disruptions by taking six big loss and Fishbone diagrams to find the cause and effect of Losses that cause failure of machine or equipment operations. The results of the study of the highest OEE value in August 2023 were 98.54%, the lowest OEE value was in April 2023 which was 0%, the cause was severe damage to the power turbine blade which required engine replacement, but was constrained by the time of the engine spare delivery process. The six big Losses factor that contributed the most to the OEE value was idling minor stoppage with an average value of 8.83% and equipment failure Losses with an average value of 8.81%.
Rancang Bangun Sistem Informasi Manajemen Apotek Berbasis Web (Study Kasus : Apotek Aya Farma)
Authors: Muhammad Khulaimi  , Mufti Syawaludin
Published: December 2023

Apotek merupakan suatu tempat pelayanan produk maupun jasa kefarmasian (obat-obatan) kepadamasyarakat.  Pengelolaan apotek dilakukan oleh seorang Apoteker yang meliputi perencanaan, pengorganisasian, pelaksanaan, pengawasan, serta penilaian terhadap kinerja apotek tersebut.  Dalam pelaksanaanya di apotek tersebut terdapat beberapa kegiatan diantaranya mengelola data obat-obatan yang ada termasuk stok obat, pembelian obat dari distributor, penjualan obat kepada konsumen, menentukan kebijakan harga jual obat, serta laporan dalam bentuk rekapitulasi seluruh aktifitas penjualan dan pembelian obat yang terjadi pada apotek tersebut.Seiring dengan perkembangan teknologi yang pesat, pengolahan data-data dalam apotek tersebut perlu ditata dengan baik dan terkomputerisasi untuk membangun suatu manajeman apotek yang efektif, efisien, dan produktif.Sistem informasi yang dihasilkan memiliki kemampuan dalam mengelola data, menyimpan data (storage), mengolah data transaksi seperti proses input data transaksi (penjualan maupun pembelian obat), menyimpan ke dalam database, serta menghasilkan informasi yang dibutuhkan diantaranya berupa laporan pembelian, penjualan, maupun stok obat yang ada.
ЯБЛОННАЯ СТЕКЛЯННИЦА SYNANTHEDON MYOPAEFORMIS (BORKHAUSEN, 1789) (LEPIDOPTERA, SESIIDAE) В АЛМАТИНСКОЙ ОБЛАСТИ КАЗАХСТАНА
Authors: Темрешев Избасар , Копжасаров Бакыт , Бекназарова Зибаш , Кошмагамбетова Меруерт , Исина Жанна , Калдыбеккызы Гульжан
Published: December 2023

В последнее время в яблоневых садах Алматинской области наблюдается повышение численности яблонной стеклянницы. Вредитель может нанести огромный ущерб садоводству, при этом многие садоводы могут не знать об этом вредителе. Иногда заселяют до 30-50 % деревьев. При первом взгляде этот вид может не восприниматься как вредитель, так как по внешнему виду несколько похож на осу. В Казахстане стеклянница ранее указывалась только для севера и северо-запада страны. По последним данным, часто отмечается на юге и юго-востоке страны. Следует отметить, что изучение яблонной стеклянницы на юго-востоке Казахстана необходимо продолжить, как опасного многоядного вредителя плодовых, способного давать вспышки массового размножения и расселятся в новых местообитаниях. В связи с этим исследования яблонной стеклянницы является актуальной в сфере садоводства.
Üniversite Öğrencilerinin Sosyal Medya Bağımlılık ve Yaşam Doyum Düzeyi Arasındaki İlişkinin İncelenmesi
Authors: BAYRAKDAROĞLU Yeşim , TÜRKMEN Muhammed Uhud , ÖNTÜRK Yavuz
Published: December 2023

Bu araştırma, Beden Eğitimi ve Spor Yüksekokulu öğrencilerinin sosyal bağımlılık ile yaşam doyum düzeyleri arasındaki ilişkiyi incelemeyi amaçlamıştır. Çalışmada, sosyal medya bağımlılığı ve yaşam doyumunu ölçmek için kullanılan ölçekler arasındaki ilişkiyi ve demografik özelliklere göre değerlendirmeler yapılmıştır. Betimsel tarama modeli temel alınarak, kolayca ulaşılabilir bir örneklem grubuyla gerçekleştirilmiştir. Çalışmanın katılımcı grubu, Gümüşhane Üniversitesi Beden Eğitimi ve Spor Yüksekokulu'nda okuyan 127 erkek ve 77 kadın olmak üzere toplam 204 öğrenciden oluşmaktadır. Veri toplama aracı olarak, Şahin ve Yağcı (2017) tarafından uyarlanan "Sosyal Medya Bağımlılık Ölçeği" ve Bekmezci ve Mert (2018) tarafından uyarlanan "Yaşam Tatmin Ölçeği" kullanılmıştır. Araştırmada öğrencilerin sosyal medya bağımlılığı ve yaşam doyum düzeyleri hakkında tanımlayıcı veriler sunulmaktadır. Analiz sonuçlarına göre, çalışma grubundaki öğrencilerin sanal tolerans, sanal iletişim, toplam sosyal medya bağımlılığı ve yaşam doyum düzeylerinin orta seviye puanlarında olduğu görülmektedir. Ayrıca, öğrencilerin sanal iletişim düzeyleri ile yaşam doyum düzeyleri arasında anlamlı bir ilişki olmadığı (p>0.05) tespit edilmiştir. Ancak, sanal tolerans ve sosyal medya bağımlılık düzeyleri ile yaşam doyum düzeyleri arasında negatif yönde düşük düzeyde anlamlı bir ilişki olduğu (p
Seasonal Fluctuations in Hemodynamic Characteristics in Patients with Increased Meteosensitivity: a Survey
Authors: Knyazeva Tatyana A. , Abramova Berta Y. , Grishechkina Irina A. , Valtseva Elena A. , Yakovlev Maxim Yu.
Published: December 2023

INTRODUCTION. Currently, the Russian Federation occupies one of the first places among the developed countries of the world in terms of mortality from cardiovascular diseases, 3–5 times higher than in developed countries. Arterial hypertension, smoking, diabetes mellitus, obesity, and other risk factors contribute to the onset and progression of cardiovascular diseases, and lifestyle modification and reduction in risk factor levels can slow their development. An increase in physical activity along with a decrease in the total calorie content of food is mandatory for reducing body weight. When combining physical exercises with climatotherapy (health path, physical exercises in the open air), it is necessary to take into account external meteorological conditions, as well as increased meteosensitivity of some patients, which are able to neutralize the therapeutic effects achieved by using, for example, health path.
AIM. To study the frequency and seasonality of the main meteopathic reactions in patients with cardiovascular diseases.
MATERIALS AND METHODS. We conducted a verbal and communicative examination of 735 patients with a body mass index of 25 kg/m2 and over, who were treated in the health resort complex “Vulan“. The analysis of patients’ answers about arterial pressure increases and complaints about other meteopathic reactions during the year according to self-monitoring data was carried out. Macroclimatic characteristics of the location of the health resort complex were also studied. The study was performed as part of the research work under the state assignment of the Ministry of Health of the Russian Federation, reg. No. 121040200110-0.
RESULTS. It was revealed that the highest frequency of increased blood pressure recorded by patients is registered in March, October, November and December, the lowest is recorded in May, June and August. At the same time, the frequencies of other meteopathic reactions, such as fear, anxiety, shortness of breath, and others, are evenly distributed throughout the year.
CONCLUSION. The study evaluated the natural climatic factors of the resort located on the Black Sea coast of the North Caucasus, by the example of the health resort complex “Vulan“ in connection with the search of favorable seasons for the treatment of cardiological patients with increased meteosensitivity. The results obtained allow us to make proposals to supplement the current regulatory documents with the data on the identified favorable periods of health resort treatment for cardiologic patients, expanding the seasonality for referring patients to the resorts of the Black Sea coast of the North Caucasus.
The Role of Computer-Aided Diagnosis in Speech Restoration in Patients with Cancer of the Oral Cavity and Oropharynx after Hemiglosectomy: a Prospective Comparative Study
Authors: Krasavina Elena A. , Choynzonov Evgeny L. , Kulbakin Denis E. , Medova Natalia A.
Published: December 2023

INTRODUCTION. Oral cavity and oropharyngeal cancers usually require extensive surgeries accompanied by damages to anatomical structures and impaired speech function.
AIM. To compare the effectiveness and terms of speech rehabilitation in patients with cancer of the oral cavity and oropharynx using various speech restoration techniques.
MATERIALS AND METHODS. We studied the effectiveness and length of speech rehabilitation in 140 patients with stages II–IV oral cavity and oropharyngeal cancer. The age of the patients ranged from 24 to 70 years. All the patients underwent hemiglosectomy. Combined modality treatment and postoperative speech rehabilitation were performed according to the technique developed in the Department of Head and Neck Tumors of the Oncology Research Institute. Speech rehabilitation effectiveness was studied on the basis of subjective and objective evaluation of speech using the computer-software complex (OnkoSpeech v 1.0).
RESULTS AND DISCUSSION. Impaired speech function of patients was observed before starting combined modality treatment and manifested as a change in the prosodic system of speech and subjective communication difficulties associated with the presence of a tumor. After surgery, all the patients demonstrated impaired speech function, ranging from distorted pronunciation to the complete absence of verbal communication. Speech rehabilitation started 8 to 29 days after surgery: in the study group I, Me = 9.6, in the study group II, Me = 9.8, values did not have statistically significant differences (p 0.05). At the beginning of speech rehabilitation, to restore activity and coordinate the work of articulatory apparatus muscles and speech expiration, special complexes of articulation and breathing exercises followed by sound pronunciation correction were performed. Postoperative speech rehabilitation resulted in the improvement of speech function in 100 % of cases. In group II, where the correction of sound pronunciation was performed on the basis of speech diagnosis data using the OnkoSpeech v 1.0 computer-software complex, it was possible to achieve a better result of sound pronunciation correction of all the studied sounds, except for hissing (lingual-frontal) [sh], [zh], [shch], [ch].
CONCLUSION. The use of the OnkoSpeech v1. ± software package for speech computer-aided diagnosis made it possible to objectively evaluate and quantify the effectiveness of the correction of the sound pronunciation of six phonemes of the Russian language, improve the results of the correction of sound pronunciation and reduce the time of speech therapy.
The Modified Myocardial Index for Evaluation of Fetal Cardiac Function in Gestational Diabetes Mellitus
Authors: OĞUZ Yüksel , ULUSOY Can Ozan , AĞAOĞLU Recep Taha , YAKUT YÜCEL Kadriye , YILMAZ Zehra
Published: December 2023

Objectives

The modified myocardial performance index (Mod‐MPI) is a new technique that is used to assess myocardial function. Gestational Diabetes can affect myocardial function and may lead to change Mod –MPI value. We aimed to evaluate fetal cardiac function with Mod-MPI in pregnant with GDM and compare with healthy pregnant.

Material and Methods

Totally 60 pregnant; 30 with GDM and 30 without disease were included into this prospective case control study. Demographic characteristics of the study group were recorded. Mod-MPI and obstetric Doppler parameters were calculated for each fetus by an experienced perinatologist. The results of the two groups were compared.

Results

There was no difference in demographic characteristics terms of age, parity and BMI. The mean Mod-MPI value was found significantly higher in pregnant with GDM when compared with healthy pregnant. The obstetric Doppler parameters were found similar between groups.

Conclusion

The utility of the Mod‐MPI in GDM pregnant is unclear in literature. Future prospective studies with larger number of cases are needed to to evaluate the utility of the Mod‐MPI as a predictor of cardiac function in fetuses of GDM mothers.
Isolation and Molecular identification of Endophytic fungi from Michelia champaca Linn. and screening for its Extracellular Enzyme Production
Authors: Talukdar Nayan , Paul Rima , Saikia Devabrata , Gogoi Jyotchna , Barman Indrani
Published: December 2023

Fungal endophytes are the group of microorganisms that occupy parts and colonize living, internal tissues of plants without causing any immediate, negative effect or noticeable injury to the host. In this study, fungal endophytes were targeted for isolation from young and healthy leaves of Michelia champaca Linn. from Guwahati region, Assam. The colony morphology was screened for observation of spores/ conidia or fruiting bodies under light compound microscope after staining. The endophyte was screened for the presence of various enzymatic activities like Amylolytic, Lipolytic, Cellulolytic, Proteolytic and catalase activity. Results showed that the isolated endophyte was a potential source of amylolytic, cellulolytic and Lipolytic activities whereas it showed negative result for catalase and proteolytic activities. It was further characterized using 1, 5.8S ribosomal RNA gene ITS sequencing and phylogenetic analysis. The molecular characterization identified it as Cladosporium pseudocladosporioides. Hence, this study showed that fungal isolate from M. champaca could be a potential source for enzymes with biological activities.
Phytoestrogens of Trifolium pratense L. as therapeutics: A review
Authors: Bajaj Madhu , Bahri Saloni , Sinha Roy Somdutta , Krishna Shambhavi , Chaturvedi Samriddhi
Published: December 2023

Trifolium pratense L., commonly known as red clover, is a dicotyledonous allogamous diploid plant. It is known to have antioxidant, anti-inflammatory, chemo-preventive and anti-spasmodic capabilities among other medicinal properties. Studies have indicated that it is extremely beneficial in managing postmenopausal symptoms and has a positive role to play in moderating rheumatoid arthritis. Products obtained from the plant, specifically phytoestrogens, are being explored for their role in cognitive therapeutics. It is also being studied as a potential cure for cancers, such as breast cancer. In this paper, we have reviewed the genomic details of Trifolium and its possible applications in the field of medicine. Phytoestrogens, their mechanism of action, isoflavones and their biosynthetic pathway along with factors affecting isoflavone concentration are also reviewed. Thus, this review summarizes the existing literature about the phytoestrogens of T. pratense and their potential use for human health and the gaps in this information. Future prospects have been enumerated to guide further research on phytoestrogens of T. pratense.
FTIR analysis and evaluation of phytochemicals from various solvent extracts of Ocimum gratissimum L. and Ocimum sanctum L.
Authors: Krishnan Remya , KS Devika , Jacson Jerry C.
Published: December 2023

The therapeutic potentiality of medicinal plants is attributed by the presence of a wide range of secondary metabolites or phytochemicals which will have various pharmacological activities. It is well known that every plant species possess complex mixture of bioactive compounds in which each component contributes to its overall bioactivity. The genus Ocimum, has long been acclaimed for their diversity and economic, nutritional, industrial and medicinal importance. The enormous information revealed by the ethnomedicinal applications of Ocimum species demands a scientific investigation into its chemical constituents. In the present study comparison of two Ocimum species, Ocimum gratissimum L. and O. sanctum L. were done in terms of phytochemical constituents and FT IR spectral analysis. Both Ocimum species showed variation in the presence of phytochemicals in different non polar to polar solvents extracts. FT-IR spectral analysis was attempted to analyze the functional groups and characteristic absorption bands & their corresponding functional groups revealed variations in fingerprint band features of Ocimum species. For O. gratissimum, the FTIR spectral peak starts at 3969.50 whereas in O. sanctum it was at 3967.57. The shared FT-IR regions between the species were 366.48, 489.92, 696.30, 1068.56, 1394.53, 2937.59 and 3728.40. Similarly, the unique bands for O. gratissimum were 1166.93 and 1512.19, while 1842.02 and 2397.52 represent that for O. sanctum. The FT-IR analysis revealed the presence of varied functional groups. Thus, the FT-IR spectra validated the presence of various phytochemicals in the plant.
Effect of Malathion (Organophosphate) on Expression of Matrix Metalloproteinases, Blood Cell Count and Reproductive Hormones as well as Ros Level of Male Rat
Authors: Bindhani Banani , Das Joydeep
Published: December 2023

Malathion, one of the oldest and probably most widely used organophosphate insecticides worldwide, is used to prevent ectoparasite insects on fruits and vegetables, mainly on agricultural crops. Our study was designed to observe the effects of malathion on some enzymes like catalase and glutathione, on some hormones like folicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), and testosterone, on Matrix Metalloproteinases (MMP) like MMP1, MMP2, and on blood cells in rats. We had used some techniques like spectrophotometry to study catalase and glutathione activity. ELISA for FSH, LH, and testosterone activity studies; protein zymography for MMP activity and haemocytometry for total and differential counts of blood cells It was observed that all hormones and enzymes expression was decreased, as was the total and differential count of blood cells. But in the case of MMP activity, both MMP1 and MMP2 expression were considerably increased under the effect of malathion. As most of the agricultural crops and fruits are consumed by humans, and as both rats and humans share one-fourth of the human genome, this study could help with research on the effects of malathion in the environment as well as on the restriction or dosage estimation for malathion use in both ecological and agricultural aspects.
Risk of mate selection: Force driving to higher foraging rate in semi urban climate in Himalayan foot hills
Authors: Singh Garima , Chaudhary Kalpana , Kumar Sachin , Sharma Gaurav
Published: December 2023

Foraging behavior is increasingly seen as an integral component in maintaining connectivity within habitat structure. Daily patterns in the foraging behavior of birds are assumed to balance the counteracting starvation, risks of predation and mate choice in breeding season in song-birds. Present study is the first investigation of the data on foraging patterns assemblage of population of Indian robin (Copshychus fulicatus L.), belongs to Semi-urban climate in Himalayan foothills. Foraging rate were found higher in male Indian robin in breeding season than non-breeding season because they need more energy to sing to attract female in breeding season, while female forage almost equal in both the season. Slight variation were found in foraging rate in morning and evening for both the sexes, evening have little more edges. This study also has significant value to study the effect of increasing urbanization on foraging, as need of recent research of ornithologist for sub- population, sub- species and species conservation.
A bio-inspired weights and structure determination neural network for multiclass classification: Applications in occupational classification systems
Authors: He Yu , Dong Xiaofan , Simos Theodore E. , Mourtas Spyridon D. , Katsikis Vasilios N. , Lagios Dimitris , Zervas Panagiotis , Tzimas Giannis
Published: December 2023

Undoubtedly, one of the most common machine learning challenges is multiclass classification. In light of this, a novel bio-inspired neural network (NN) has been developed to address multiclass classification-related issues. Given that weights and structure determination (WASD) NNs have been acknowledged to alleviate the disadvantages of conventional back-propagation NNs, such as slow training pace and trapping in a local minimum, we developed a bio-inspired WASD algorithm for multiclass classification problems (BWASDC) by using the metaheuristic beetle antennae search (BAS) algorithm to enhance the WASD algorithm's learning process. The BWASDC's effectiveness is then evaluated through applications in occupational classification systems. It is important to mention that systems of occupational classification serve as a fundamental indicator of occupational exposure. For this reason, they are highly significant in social science research. According to the findings of four occupational classification experiments, the BWASDC model outperformed some of the most modern classification models obtainable through MATLAB's classification learner app on all fronts.
The Pan-liver Network Theory
Authors: Zhang Yaxing , Fang Xian-Ming
Published: December 2023

In traditional Chinese medicine (TCM), the liver is the “general organ” that is responsible for governing/maintaining the free flow of qi over the entire body and storing blood. According to the classic five elements theory, zang–xiang theory, yin–yang theory, meridians and collaterals theory, and the five–viscera correlation theory, the liver has essential relationships with many extrahepatic organs or tissues, such as the mother–child relationships between the liver and the heart, and the yin–yang and exterior–interior relationships between the liver and the gallbladder. The influences of the liver to the extrahepatic organs or tissues have been well-established when treating the extrahepatic diseases from the perspective of modulating the liver by using the ancient classic prescriptions of TCM and the acupuncture and moxibustion. In modern medicine, as the largest solid organ in the human body, the liver has the typical functions of filtration and storage of blood; metabolism of carbohydrates, fats, proteins, hormones, and foreign chemicals; formation of bile; storage of vitamins and iron; and formation of coagulation factors. The liver also has essential endocrine function, and acts as an immunological organ due to containing the resident immune cells. In the perspective of modern human anatomy, physiology, and pathophysiology, the liver has the organ interactions with the extrahepatic organs or tissues, for example, the gut, pancreas, adipose, skeletal muscle, heart, lung, kidney, brain, spleen, eyes, skin, bone, and sexual organs, through the circulation (including hemodynamics, redox signals, hepatokines, metabolites, and the translocation of microbiota or its products, such as endotoxins), the neural signals, or other forms of pathogenic factors, under normal or diseases status. The organ interactions centered on the liver not only influence the homeostasis of these indicated organs or tissues, but also contribute to the pathogenesis of cardiometabolic diseases (including obesity, type 2 diabetes mellitus, metabolic [dysfunction]-associated fatty liver diseases, and cardio-cerebrovascular diseases), pulmonary diseases, hyperuricemia and gout, chronic kidney disease, and male and female sexual dysfunction. Therefore, based on TCM and modern medicine, the liver has the bidirectional interaction with the extrahepatic organ or tissue, and this established bidirectional interaction system may further interact with another one or more extrahepatic organs/tissues, thus depicting a complex “pan-hepatic network” model. The pan-hepatic network acts as one of the essential mechanisms of homeostasis and the pathogenesis of diseases.
Icariside II Suppresses Ferroptosis to Protect Against MPP+-Induced Parkinson's Disease through Keap1/Nrf2/GPX4 Signaling
Authors: Fan Wenbo , Zhou Jianwu
Published: December 2023

Parkinson's disease (PD) is recognized as a degenerative and debilitating neurodegenerative disorder. The novel protective role of icariside II (ICS II) as a plant-derived flavonoid compound in neurodegenerative diseases has aroused much attention. Herein, the definite impacts of ICS II on the process of PD and the relevant action mechanism were studied. Human neuroblastoma SK-N-SH cells were challenged with 1-methyl-4-phenylpyridinium ion (MPP+) to construct the PD cell model. MTT assay and flow cytometry analysis, respectively, appraised cell viability and apoptosis. Caspase 3 Activity Assay examined caspase 3 activity. Corresponding kits examined oxidative stress levels. BODIPY 581/591 C11 assay evaluated lipid reactive oxygen species. Iron Assay Kit assessed iron content. Western blot tested the expression of apoptosis-, ferroptosis- and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4) signaling-associated proteins. Molecular docking verified the binding of ICS II with Keap1. The existing experimental results unveiled that ICS II elevated the viability whereas reduced the apoptosis, oxidative stress, and ferroptosis in MPP+-treated SK-N-SH cells in a concentration-dependent manner. Furthermore, ICS II declined Keap1 expression while raised Nrf2, heme oxygenase 1, and GPX4 expression. In addition, ICS II had a strong binding with Keap1 and Nrf2 inhibitor ML385 partially abolished the suppressive role of ICS II in MPP+-triggered apoptosis, oxidative stress, and ferroptosis in SK-N-SH cells. To summarize, ICS II might inhibit apoptosis, oxidative stress, and ferroptosis in the MPP+-stimulated PD cell model, which might be due to the activation of Keap1/Nrf2/GPX4 signaling.
Radiofrequency ablation of parathyroid gland as a treatment modality for primary hyperparathyroidism – A novel bedside procedure in critically ill patients
Authors: Shivashankariah Vikram Halkurke , Tiwari Dheeraj Kumar , Ramamurthy Madhusudan , Harinarayan C. V. , Krishnamurthy Deepak , Janardhan Raghu
Published: December 2023

Primary hyperparathyroidism caused by parathyroid adenoma is managed surgically so far. Radiofrequency ablation (RFA) of the parathyroid gland is a new modality which is gradually replacing open neck surgery. RFA is done as a bedside procedure in less than 30 min, with no scar, post-operative management, etc. In addition, it has a major advantage for patients who are not fit for anaesthesia, other comorbidities and critically ill patients. We report a case of parathyroid adenoma successfully ablated using radiofrequency in a critically ill patient with comorbidities.
18Fluorodeoxyglucose positron emission tomography-computed tomography findings in bilateral adrenal metastases in renal cell carcinoma
Authors: Sireesha Polisetty , Kalawat Tekchand C. , Ajit Nimmagadda , Hemalatha D. S. , Priya R. Ramya
Published: December 2023

Bilateral adrenal metastases is a rare manifestation which can be seen in malignancies such as breast, lung carcinoma and melanomas. Adrenal metastases are usually detected on one side or more rarely on both sides. Molecular imaging with 18fluorodeoxyglucose positron emission tomography-computed tomography often shows unilateral or bilateral adrenal metastases in various malignancies. Here, we present a case of renal cell carcinoma that presented with widespread skeletal and bilateral adrenal metastases.