bluuebunny/crossref_metadata_2025 huggingface dataset:
The Need for a Journal of Digital Innovation for Humanity - JDIH
Authors: Saade Raafat
Published: November 2020

Aim/Purpose
This article presents the results of reviewing journal outlets where research in digital innovation and transformation are published. Our aim is to make the case for a much-needed journal dedicated research and practice in the digital innovation / transformation and human / humanity sphere.

Background
Digital innovation has become part of our daily lives whether we are aware of it or not. Over 4 billion people are using blockchain, IoT, cloud computing, mobile technologies, social media and artificial intelligence, yet very little is understood of their effects on humans. Research in this area is relatively scarce and dispersed across diverse types of journals. The few articles published in the area of digital innovation and humanity provide just a hint on the importance of the subject matter. Ultimately, we need to understand what technology is for humans. Is the digitalization phenomenon a utopia or a dystopia? What we really need is a truly human-centered transformation of digital innovation.

Methodology
The Publish and Perish literature search desktop application and Google search engine were used to identify journals that have published in the area of digital innovation with a focus on humanity. SCIMAGO was used to understand the subject area clusters of these journals.

Findings
There is relatively little research in the digital innovation and humanity arena. Articles are scarce and dispersed over a diversified range of journal subject areas. Only two journals are concentrated on publishing research in the area of digital innovation. No journals were found in humanity and digital innovation.

Impact on Society
In this article, we stress the need for a journal in digital innovation and humanity as an outlet for the work of researchers, practitioners, and educators. The article inaugurates the first paper for the journal. The journal will act as an outlet for researchers, practitioners, and educators and provide a forum for knowledge sharing and collaboration with the ultimate goal of improving human quality of life.
IMMERSIVE TECHNOLOGIES IN A HIGHER SCHOOL IN THE MODERN DIGITAL REALITY
Authors: Abdraimova E. , Shoibekova A. , Zhorabaev K.
Published: November 2020

Immersive technologies and virtual reality technologies have become a powerful and promising tool in education due to their unique technological characteristics that distinguish them from other it applications. In the higher education system the coronavirus pandemic (COVID-19) has played a role as an accelerator for the use of all forms and methods of e-learning. Mobile learning (m-learning) is characterized in the context of "smart" education, which has become one of the most viable and popular in terms of flexibility in the organization of the educational process and access to educational resources, virtualization in training. Also, mixed (hybrid) educational technologies that allow e-learning at the transition stage from their use to implementation. Providing the latest statistical data on the degree of penetration of Kazakhstan users into the mobile Internet and its development the advantages of an innovative form of education are revealed in the context.
Primary breast carcinoma en cuirasse. A rare presentation of an aggressive malignancy and review of the literature
Authors: Salemis Nikolaos S. , Christofyllakis Charalambos , Spiliopoulos Kyriakos
Published: November 2020

Breast carcinoma en cuirasse is a very rare form of cutaneous metastases of breast cancer. The clinical presentation is that of a diffuse indurated carcinomatous infiltration of the skin and subcutaneous tissues of the mammary region and the anterior aspect of the chest. In most cases, breast carcinoma en cuirasse develops post-mastectomy and represents a dramatic presentation of an aggressive tumor associated with a dismal prognosis. Because of the rarity of this type of malignancy, the optimal approach to treatment has not been clearly defined. The systemic treatment has been associated with limited efficacy, and the primary goal is palliative care and preservation of the quality of life through skin-directed therapies. Herein, a very rare case of primary breast carcinoma en cuirasse is presented, along with a review of the literature. Early diagnosis and prompt treatment of any potential skin metastases of breast cancer are essential to prevent the catastrophic natural progression of the disease.
Quantitative evaluation of elasticity of lower orbicularis oris muscle during the lip closing measurement using sonographic elastography
Authors: Hayashi-Sakai Sachiko , Kobayashi Taichi , Sakamoto Makoto , Hayashi Takafumi , Morise Yusuke , Nikkuni Yutaka , Takamura Masaki , Sakai Jun , Shimomura-Kuroki Junko , Ike Makiko , Nishiyama Hideyoshi
Published: November 2020

BACKGROUND: Lip closing functions have never been evaluated from the viewpoint of elastic properties. OBJECTIVES: The purpose of the present study was to investigate the behavior of the lower orbicularis oris muscle during a button-pull exercise to measure lip closing force and quantitatively evaluate its elastic properties using sonographic elastography. METHODS: Appropriate compression loads for elastography were randomly measured on one of three types of acoustic couplers on three examiners. Compression tests were performed on three types of acoustic couplers within the appropriate compression load. Using the acoustic coupler with the lowest elastic modulus, the strain ratio of the lower orbicularis oris muscle during lip closing was measured, and elastography was performed on six males under tension loads of 0–8 N. RESULTS: The intraclass correlation coefficient (1, 3) for the tension load of 0 N was 0.81. Elastography showed that the strain ratio values increased significantly (p < 0.05) as the tension load increased. CONCLUSIONS: Combining the data obtained from lip closing test devices and sonographic elastography enabled the muscle performance to be evaluated objectively and accurately.
Application of polyethylene air-bubble cushions to improve the shock absorption performance of Type I construction helmets for repeated impacts
Authors: Wu John Z. , Pan Christopher S. , Ronaghi Mahmood , Wimer Bryan M. , Reischl Uwe
Published: November 2020

BACKGROUND: The use of helmets was considered to be one of the important prevention strategies employed on construction sites. The shock absorption performance of a construction (or industrial) helmet is its most important performance parameter. Industrial helmets will experience cumulative structural damage when being impacted repeatedly with impact magnitudes greater than its endurance limit. OBJECTIVE: The current study is to test if the shock absorption performance of Type I construction helmets subjected to repeated impacts can be improved by applying polyethylene air-bubble cushions to the helmet suspension system. METHODS: Drop impact tests were performed using a commercial drop tower test machine following the ANSI Z89.1 Type I drop impact protocol. Typical off-the-shelf Type I construction helmets were evaluated in the study. A 5 mm thick air-bubble cushioning liner was placed between the headform and the helmet to be tested. Helmets were impacted ten times at different drop heights from 0.61 to 1.73 m. The effects of the air-bubble cushioning liner on the helmets’ shock absorption performance were evaluated by comparing the peak transmitted forces collected from the original off-the-shelf helmet samples to the helmets equipped with air-bubble cushioning liners. RESULTS: Our results showed that a typical Type I construction helmet can be subjected to repeated impacts with a magnitude less than 22 J (corresponding to a drop height 0.61 m) without compromising its shock absorption performance. In comparison, the same construction helmet, when equipped with an air-bubble cushioning liner, can be subjected to repeated impacts of a magnitude of 54 J (corresponding to a drop height 1.52 m) without compromising its shock absorption performance. CONCLUSIONS: The results indicate that the helmet’s shock absorbing endurance limit has been increased by 145% with addition of an air-bubble cushioning liner.
A braided stent becomes flattened inside a curved catheter tube: A micro-CT imaging study
Authors: Shigematsu Taiki , Otani Tomohiro , Tomotake Shotaro , Shiozaki Shunya , Wada Shigeo
Published: November 2020

BACKGROUND: The braided stent is a widely accepted endovascular treatment device consisting of woven metal wires. One of the unsolved issues for the braided stent is the stent flattening phenomena when deployed into highly curved arteries. Although a recent computational study highlighted that the mechanical state of the stent inside the catheter before the deployment plays an essential role in causing stent flattening, there is no experimental observation for the stent inside the curved catheter. OBJECTIVE: We investigated braided stent shapes in curved catheter tubes with various curvatures by micro-computed tomography (CT). METHODS: A braided stent was deployed into catheter tubes and set in rectangular cases with constant curvature. The three-dimensional shape of the stent was imaged by micro-CT, and its cross-sectional flatness was quantitatively assessed. RESULTS: Stent flattening occurred in cases of high curvatures of the outer side of the tube curvature, and the degree of flatness increased with increasing tube curvature. This demonstrates that stent flattening can be caused inside the highly curved catheter before deployment. CONCLUSIONS: This preliminary and first observational report provides new insight into the mechanism of stent flattening and emphasizes the importance of the geometrical and mechanical state of the stent inside the catheter.
Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study
Authors: Tripathi Garima , Miyazaki Toshiki
Published: November 2020

BACKGROUND: Microbeads for bone repair have been widely studied because they can be conveniently used in clinical applications. OBJECTIVE: This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices. METHODS: Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. RESULTS: Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. The compressive strength of the blocks fabricated from the beads was around 120 MPa irrespective of the type of CaP. The initial release rate of the model drug methylene blue was suppressed by the addition of CaP. CONCLUSION: The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
A PSO algorithm-based seasonal nonlinear grey Bernoulli model with fractional order accumulation for forecasting quarterly hydropower generation
Authors: Jiang Jianming , Wu Wen-Ze , Li Qi , Zhang Yu
Published: November 2020

The hydropower plays a key role in electricity system owing to its renewability and largest share of clean electricity generation that promotes sustainable development of national economy. Developing a proper forecasting model for the quarterly hydropower generation is crucial for associated energy sectors, which could assist policymakers in adjusting corresponding schemes for facing with sustained demands. For this purpose, this paper presents a fractional nonlinear grey Bernoulli model (abbreviated as FANGBM(1,1)) coupled seasonal factor and Particular Swarm Optimization (PSO) algorithm, namely PSO algorithm-based FASNGBM(1,1) model. In the proposed method, the moving average method that eliminates the seasonal fluctuations is introduced into FANGBM(1,1), then in which the structure parameters of FASNGBM(1,1) are determined by PSO. Based on hydropower generation of China from the first quarter of 2011 to the final quarter of 2018 (2011Q1-2018Q4), the numerical results show that the proposed model has a better performance than that of other benchmark models. Eventually, the quarterly hydropower generation of China from 2019 to 2020 are forecasted by the proposed model, according to results, the hydropower generation of China will reach 11287.14 × 108 Kwh in 2020.
An integrated neural network with nonlinear output structure for interval-valued data
Authors: Wang Degang , Song Wenyan , Pedrycz Witold , Cai Lili
Published: November 2020

In this paper, an integrated model combining interval deep belief network (IDBN) and neural network with nonlinear weights, called IDBN-NN, is proposed for interval-valued data modeling. Firstly, the IDBN with variable learning rate is designed to initialize parameters of each sub-model. Based on a modified contrastive divergence algorithm the least square method is adopted to identify the coefficients of nonlinear weights in the output layer. Then, to improve the modeling accuracy, the Fuzzy C-Means (FCM) method and the Particle Swarm Optimization (PSO) algorithm are applied to tune the weights of sub-models. Though each sub-model can capture the nonlinear feature of the original system, by intersecting cut sets the synthesizing modeling scheme can further improve the performance of the proposed model. Some numerical examples show that the IDBN-NN with nonlinear output structure can achieve higher accuracy than some interval-valued data modeling methods.
Fuzzy filters of Sheffer stroke Hilbert algebras
Authors: Oner Tahsin , Katican Tugce , Saeid Arsham Borumand
Published: November 2020

The aim of this study is to introduce fuzzy filters of Sheffer stroke Hilbert algebra. After defining fuzzy filters of Sheffer stroke Hilbert algebra, it is shown that a quotient structure of this algebra is described by its fuzzy filter. In addition to this, the level filter of a Sheffer stroke Hilbert algebra is determined by its fuzzy filter. Some fuzzy filters of a Sheffer stroke Hilbert algebra are defined by a homomorphism. Normal and maximal fuzzy filters of a Sheffer stroke Hilbert algebra and the relation between them are presented. By giving the Cartesian product of fuzzy filters of a Sheffer stroke Hilbert algebra, various properties are examined.
Hesitant fuzzy graphs, hesitant fuzzy hypergraphs and fuzzy graph decisions1
Authors: Gong Zengtai , Wang Junhu
Published: November 2020

Up to now, there have been a lot of research results about multi-attribute decision making problems by fuzzy graph theory. However, there are few investigations about multi-attribute decision making problems under the background of indecisiveness. The main reason is that the difference of cognition and the complexity of thinking by decision makers, for the same question have different opinions. In this paper, we proposed a hesitant fuzzy hypergraph model based on hesitant fuzzy sets and fuzzy hypergraphs. At the same time, some basic graph operations of hesitant fuzzy hypergraphs are investigated and several equivalence relationship between hesitant fuzzy hypergraphs, hesitant fuzzy formal concept analysis and hesitant fuzzy information systems are discussed. Since granular computing can deal with multi-attribute decision-making problems well, we considered the hesitant fuzzy hypergraph model of granular computing, and established an algorithm of multi-attribute decision-making problem based on hesitant fuzzy hypergraph model. Finally an example is given to illustrate the effectiveness of the algorithm.
Multi-criteria collaborative filtering using rough sets theory
Authors: Demirkiran Emin T. , Pak Muhammet Y. , Cekik Rasim
Published: November 2020

Recommender systems have recently become a significant part of e-commerce applications. Through the different types of recommender systems, collaborative filtering is the most popular and successful recommender system for providing recommendations. Recent studies have shown that using multi-criteria ratings helps the system to know the customers better. However, bringing multi aspects to collaborative filtering causes new challenges such as scalability and sparsity. Additionally, revealing the relation between criteria is yet another optimization problem. Hence, increasing the accuracy in prediction is a challenge. In this paper, an aggregation-function based multi-criteria collaborative filtering system using Rough Sets Theory is proposed as a novel approach. Rough Sets Theory is used to uncover the relationship between the overall criterion and the individual criteria. Experimental results show that the proposed model (RoughMCCF) successfully improves the predictive accuracy without compromising on online performance.
Extended implicative groupoids
Authors: Sameri E. , Borzooei R.A.
Published: November 2020

In this paper, we generalize the concept of extended order algebras in order to get a new algebraic structure called “extended implicative groupoid”. First, we define the notions of pre-weak extended, weak extended, right extended and left extended implicative groupoid. Then we introduce the concept of extended implicative groupoid by using these notions. In addition, the special properties of these structures, such as the existence of MacNeille completion and adjoint product are studied. Finally, we prove that the class of symmetrical associative complete distributive extended implicative groupoids, coincides with complete residuated lattices.
Induced L-bornological vector spaces and L-Mackey convergence1
Authors: Jin Zhen-yu , Yan Cong-hua
Published: November 2020

Motivated by the concept of lattice-bornological vector spaces of J. Paseka, S. Solovyov and M. Stehlík, which extends bornological vector spaces to the fuzzy setting over a complete lattice, this paper continues to study the theory of L-bornological vector spaces. The specific description of L-bornological vector spaces is presented, some properties of Lowen functors between the category of bornological vector spaces and the category of L-bornological vector spaces are discussed. In addition, the notions and some properties of L-Mackey convergence and separation in L-bornological vector spaces are showed. The equivalent characterization of separation in L-bornological vector spaces in terms of L-Mackey convergence is obtained in particular.
A task orchestration approach for efficient mountain fire detection based on microservice and predictive analysis in IoT environment
Authors: Imran  , Ahmad Shabir , Kim Do Hyeun
Published: November 2020

Mountains are attraction spots for tourists, and tourism contributes to the country’s gross domestic product. Mountains have many benefits such as biodiversity, tourism, and the supplication of food, to name a few. However, there are challenges to protect mountain lives from hazards such as fire caused by tourist activities in mountains. The in-time fire detection and notification to the authorities have always been the central point in literature studies, and different studies have been carried out to optimize the notification time. In this paper, we model the fire detection and notification as a real-time internet of things application and uses task orchestration and task scheduling mechanism to provide scalability along with optimal latency. The proposed fire detection and prediction mechanism detect mountain fire at the earliest stage and provide predictive analysis to prevent damage to mountain life and tourists. The architecture is based on microservice-based IoT task orchestration mechanism and device virtualization, which is not only lightweight but also handles a single problem in parallel chunks, thus optimizes the latency. The in-time information about the fire is used for predictive analysis and notified to safety authorities which helps them to make a more informed decisions to minimize the damage caused by mountain fire. The performance of the proposed mechanism is evaluated in terms of different measures such as RMSE, MAPE, MSE, and MAPE. The proposed work approaches the fire detection and notification as a collection of tasks, and thus those tasks are selected for deployment which are guaranteed to be executed and have minimum latency. This idea of pre-planing the latency and task execution is the first attempt to the best of the authors’ knowledge.
q-Rung orthopair fuzzy graphs under Hamacher operators
Authors: Akram Muhammad , Alsulami Samirah , Karaaslan Faruk , Khan Ayesha
Published: November 2020

A q-rung orthopair fuzzy set (q-ROFS) is more practical and powerful than intuitionistic fuzzy set (IFS) and Pythagorean fuzzy set (PFS) to model uncertainty in various decision-making problems. In this research article, we introduce the notion of q-rung orthopair fuzzy Hamacher graphs (q-ROFHGs). We utilize the Hamacher operators because they are flexible and parameterized in decision making. We determine the energy of q-ROFHGs as well as the energy of splitting and shadow q-ROFHGs. In addition, we propose the Randić energy of q-ROFHG and its some substantial results. Further, we present the idea of q-rung orthopair fuzzy Hamacher digraphs (q-ROFHDGs). We solve a decision-making numerical example related to the selection of best housing society for investment by calculating the energy and Randić energy of q-ROFHDGs and an algorithm to exhibit the applicability of the presented concepts in decision making. Finally, we present the conclusion.
Tissue Based Biomarkers for Metastatic Clear Cell Renal Carcinoma: A Systematic Review
Authors: Schmidt Andrew L. , Bain Paul A. , McGregor Bradley A.
Published: November 2020

Background:

Treatments for metastatic clear cell renal carcinoma (mccRCC) are evolving with multiple targeted and immune therapy drugs currently approved by regulatory agencies as single agents or in combination. Developing predictive biomarkers to determine which patients derive a differential benefit from a particular treatment is an area of ongoing clinical research.

Objective:

We sought to systematically evaluate the role of tumour tissue-based biomarkers that assist in selection of therapy for mccRCC.

Methods:

Literature addressing the role of biomarkers in mccRCC was identified through a search of the electronic databases MEDLINE, Embase, and the Web of Science and a hand search of major conference abstracts (from Jan 2010 –Sep 2020). Abstracts were screened to identify papers meriting full-text review. Studies with a comparison arm were included to assess biomarker relevance. A narrative review of studies was performed.

Results:

The literature search yielded 6784 potentially relevant articles. 133 articles met criteria for full text review, and 10 articles were identified by scanning bibliographies of relevant studies. A total of 33 articles (involving 13 studies) were selected for data extraction and subsequent review.

Conclusions:

Predictive biomarkers for immediate use in the clinic are lacking, and embedding their evaluation and validation in future clinical trials is needed to refine practice and patient selection.
MMoOn Core – the Multilingual Morpheme Ontology
Authors: Klimek Bettina , Ackermann Markus , Brümmer Martin , Hellmann Sebastian
Published: November 2020

In the last years a rapid emergence of lexical resources has evolved in the Semantic Web. Whereas most of the linguistic information is already machine-readable, we found that morphological information is mostly absent or only contained in semi-structured strings. An integration of morphemic data has not yet been undertaken due to the lack of existing domain-specific ontologies and explicit morphemic data. In this paper, we present the Multilingual Morpheme Ontology called MMoOn Core which can be regarded as the first comprehensive ontology for the linguistic domain of morphological language data. It will be described how crucial concepts like morphs, morphemes, word forms and meanings are represented and interrelated and how language-specific morpheme inventories can be created as a new possibility of morphological datasets. The aim of the MMoOn Core ontology is to serve as a shared semantic model for linguists and NLP researchers alike to enable the creation, conversion, exchange, reuse and enrichment of morphological language data across different data-dependent language sciences. Therefore, various use cases are illustrated to draw attention to the cross-disciplinary potential which can be realized with the MMoOn Core ontology in the context of the existing Linguistic Linked Data research landscape.
Thermography in posterior scleritis
Authors:   Narayana Nethralaya Eye Hospital, Bangalore, India, Kawali A. , Sanjay S. ,   Narayana Nethralaya Eye Hospital, Bangalore, India, Mahendradas P. ,   Narayana Nethralaya Eye Hospital, Bangalore, India, Shetty R. ,   Narayana Nethralaya Eye Hospital, Bangalore, India
Published: November 2020

Aim: to evaluate the utility of thermography in posterior scleritis (PS).Patients and Methods: this prospective observational case-control study included 6 patients with monolateral PS (study group) and 10 healthy volunteers (control group). Ocular surface temperature (OST) was measured in all participants using a non-contact thermal camera (FLIRTM) integrated onto a smartphone (CAT S 60). The difference in OST between the affected eye and the healthy (fellow) eye on thermograms (Δt) was measured at each visit in both groups. Maximum (ΔtMax) and minimum (ΔtMin) Δt for each eye as well as the amplitude of fluctuations (ampΔt) referred to as the difference between ΔtMax and ΔtMin were calculated for each eye. AmpΔt was compared between the groups.Results: in a total of 6 PS patients, B-scan ultrasonography revealed the thickening of the posterior sclera. Choroidal folds (n=4), internal limiting membrane fold (n=2), subretinal fluid (n=3), and optic disc edema (n=2) were identified by eye fundus exam. At presentation, Δt was maximum in all PS patients and reduced unequally after starting treatment. Mean ampΔt was 1.21 °C (1.47–1.04 °C) in PS group and 0.44 °C (0.13–0.63 °C) in the control group. 3 out 6 PS patients were diagnosed with recurrences as demonstrated by OST spikes compared to previous measurements.Conclusion: this article describes a novel technique of the measurement and monitoring of OST. It was demonstrated that PS is associated with the increase in OST measured by thermography. Further large-scale studies are needed to evaluate the potentialities of thermography for detecting occult or subclinical intraocular inflammation.Keywords: ocular thermography, posterior scleritis, ocular surface temperature, eye temperature, occult inflammation.For citation: Kawali A., Sanjay S., Mahendradas P., Shetty R. Thermography in posterior scleritis. Russian Journal of Clinical Ophthalmology. 2020;20(4):204–208. DOI: 10.32364/2311-7729-2020-20-4-204-208.
Glimpsing Truth and “[Making] it whole”: Art as Personal and Social Unity in Virginia Woolf
Authors: Fairbairn Megan
Published: November 2020

Multiplicity and unity echo throughout Virginia Woolf’s work, especially as related to art and its function. All three intersect in Woolf’s conception of moments of being, which induce a state of heightened perception and cognition, allowing the subject to transcend everyday modes of thinking and being. These moments are integral to art, as they inspire artists to create in order to unify intangible and fleeting experiences. Woolf’s novel To the Lighthouse follows painter Lily Briscoe along her journey from experiencing moments of being to exacting her vision on the canvas, focusing particularly on the hegemonic obstacles that interrupt this process. Woolf’s later novel Between the Acts narrativizes the playwright and director Miss La Trobe, focusing less on her internal process of creating art and more on how her art operates socially and ethically, as it necessarily involves the participation of human beings and nature itself. Through artist characters, both novelsshow how moments of being, as glimpses of higher unity, inspire works of art which in turn unify on both personal and socioethical levels.
Perbedaan Pijat Counterprssure Dan Relaksasi Nafas Dalam Terhadap Adaptasi Nyeri Ibu Bersalin Di Bpm Ny.e Di Kecamatan Grabag Kabupaten Magelang
Authors: Trianita Oktavia Bryan , Rahmawati Wiwn Renny , Talib Susi Tentrem
Published: November 2020

Latar Belakang : Rasa nyeri pada persalinan disebabkan oleh kombinasi peregangan segmen bawah rahim (selanjutnya serviks) dan iskemia (hipoksia) otot-otot rahim. Reaksi terhadap nyeri merupakan respons yang sifatnya sangat individual. Reaksi ini tergantung pada kepribadian, kondisi emosional serta tingkat pemahaman pasien, latar belakang kultural, keluarga serta pendidikannya, dan pengalaman sebelumnya. Penanganan secara non-farmakologis yaitu pijat dan relaksasi nafas dalam.Tujuan : Mengetahui perbedaan pijat counterpressure dan relaksasi nafas dalam terhadap adaptasi nyeri ibu bersalin.Metode Penelitian : Penelitian ini menggunakan rancangan quasi-eksperiment dengan desain metode penelitian 2 group pre and post-test design, yang mana penelitian ini melibatkan 2 kelompok 1 (kelompok pijat counterpressure) dan kelompok 2 (kelompok relaksasi nafas dalam). Teknik sampling yang digunakan adalah accidental sampling.Hasil : Hasil analisis penerapan pada kelompok pijat counterpressure terhadap penurunan nyeri ibu bersalin dengan uji Wilcoxon didapatkan hasil p = 0,001 (p < 0,05) dan pada kelompok relaksasi nafas dalam dengan uji Wilcoxon didapatkan hasil p = 0,083 (p > 0,005). Sehingga pada kelompok pijat counterpressure (p < 0,05) Ha diterima yang mengartikan bahwa ada perbedaan yang bermakna pada perlakuan pijat counterpressure dan relaksasi nafas dalam.Kesimpulan : pijat counterpressure lebih efektif dalam adaptasi nyeri ibu bersalin. Background: pain in labor is caused by a combination of stretching of the lower uterine segment (hereinafter the cervix) and ischemia (hypoxia) muscles of the uterus. Reaction to pain is a response that is very individual. This reaction depends on the personality, emotional state and the level of patient understanding, cultural background, family and education, and previous experience. Handling of non-pharmacological namely relaxation massage and deep breathing.Objective: To determine differences in massage counterpressure relaxation and deep breathing against maternal adaptation pain.Methods: This study used adesign quasi-experimental with the design of research method 2 group pre and post-test design,which this study involved two groups 1  massage (counterpressure group)and group 2 (deep breathing relaxation group). The sampling technique used was accidental sampling.Results: Analysis of the application of the massage group counterpressure against maternal pain reduction with the Wilcoxon test showed p = 0.001 (p <0.05) and the deep breathing relaxation group with the Wilcoxon test showed p = 0.083 (p> 0.005). So that the massage group counterpressure (p <0.05) Ha accepted which means that there are significant differences in treatment counterpressure massage and relaxation massage deep breath.Conclusion: counterpressure be more effective in pain adaptation birth mothers.
Histological and ultrastructural changes in turkey liver under intensive rear-ing and influence of xenobiotics
Authors: Shchebentovska O. М. , Kostyniuk A. K.
Published: November 2020

Liver problems of various etiologies in turkeys have been reported in many countries for the last 20 years. Poultry dies having no clinical manifestations of the disease, and at pathological autopsy, diffuse haemorrhages and marked dystrophic changes of the organ are noted. To date, there are several factors that can cause such changes, these are unbalanced amino-acid feed, insufficient calcium, biotin, selenium, the very high energy content of feed; zootechnical factors – limited mobility of birds due to cage density violations, high temperature; genetic factors – the influence of estrogens; infectious factors – E. coli, Clostridium, and viruses of Picornaviridae family. The article describes the histopathological and ultrastructural changes in the turkey liver under the influence of various factors. The material for the research was obtained from a farm where turkeys of the “Hybrid Converter” cross are grown, same age, fed with a standard diet that changed according to the technological map of cultivation. On the 50th day of life, a pathological autopsy of the dead poultry was performed, pieces of liver were selected for histological and ultrastructural examination. The visual assessment revealed significantly enlarged liver, the colour from dark red to light brown, flabby consistency. In some cases, diffuse fatty infiltrations of hepatocytes were histologically revealed, in other cases, focal necrosis with the growth of the connective tissue and the formation of massive perivascular couplings were registered. Large vacuolar fatty degeneration of hepatocytes with subsequent development of fibrosis indicates chronic intoxication, probably caused by slow breakdown of fatty acids in cells due to insufficient oxidative phosphorylation, as well as reduced levels of lipotropic factors: choline, methionine and the vitamins. At the ultrastructural level, a large number of lipid inclusions of various sizes, dystrophic changes in mitochondria were observed, which indicates a decrease in the synthetic activity of cells.
Content of lipid peroxidation products in pig meat at industrial and domestic slaughter
Authors: Stronskyi I. Yu. , Simonov M. R. , Stronskyi Yu. S.
Published: November 2020

The nutritional value of meat, its organoleptic characteristics and therefore the shelf life depend on the content of lipid peroxidation products in it. Intermediates of peroxidation can have a toxic effect on the human body and are one of the main factors of non-microbial degradation of meat and various products. Based on this, the aim of this work was to study the content of lipid peroxidation products in pig meat of different origins. Furthermore, the aim was to establish the level of primary and secondary products of lipid peroxidation in meat, selected from different parts of the carcass. Meat samples were taken immediately after the pigs were slaughtered. A total of 3 meat samples were taken from 10 pig carcasses. One sample of meat was taken from each of the carcasses from the cervical, dorsal and femoral parts. The first 5 pigs were kept in industrial conditions and were slaughtered within the industrial slaughterhouse, and the second 5 were kept and slaughtered in personal farms. The results of the research showed that the highest level of primary and secondary products of lipid peroxidation is registered in the meat obtained from the dorsal part of pork carcass, which is primarily due to its fat-acid composition. In meat selected from the cervical and femoral parts, the level of the studied indicators is probably lower. During storage, lipid peroxidation activity increases from the first to the fourth day and decreases slightly until the seventh. The increase in the level of all studied indicators on the fourth day of meat storage is due to the fact that natural components contained in muscle tissue, such as ferrum, myoglobin, hydrogen peroxide and ascorbic acid can cause lipid oxidation, acting as catalysts or promoting the formation of reactive oxygen species. In the case of domestic keeping and slaughter, pig meat was found to have significantly higher concentrations of diene conjugates, lipid hydroperoxides and TBA-active products compared to industrial. The main prerequisite for this is an unbalanced diet, especially in terms of the content of substances that have antioxidant properties.
Aldosereductase: structure, mechanism of action, biological role and functioning according to normo and hyperglycemia
Authors: Makukh Y. M. , Gryvul T. M. , Krasnevich A. Ya. , Vignan D. S.
Published: November 2020

The review summarizes the literature on the structure, biological role and mechanism of action of aldose reductase at different blood glucose levels. Aldosereductase is the first enzyme of the sorbitol (polyol) pathway to glucose metabolism. In mammals, it is a monomeric protein with a molecular weight of 32–56 kDa, has 347–370 amino acid remainders. Its secondary structure consists of α-helices and β-bends, which alternate in 8 units. The active site of the enzyme is located at the C-terminus of the β-bend and contains a glutathione-binding domain. The active site of aldose reductase consists of two sites: substrate-binding and catalytic. The first is formed mainly by the residues of hydrophilic amino acids, and the second, by hydrophobic ones. The interaction of the enzyme with a coenzyme causes conformational changes in aldose reductase. It is believed that the enzyme functions according to the principle of an ordered “bi-bi” mechanism, that is, the coenzyme binds first, and the oxidized product is released last. The reduction of aldehydes of aldose reductase includes several stages: the interaction of the enzyme with NADPH and the formation of a binary complex, the acceptance of the substrate and the formation of a ternary complex (enzyme-coenzyme-substrate) and the separation of the alcohol-reaction product and the oxidized coenzyme. According to normoglycemia in mammalian cells via the sorbitol pathway, up to 1–3 % of intracellular glucose is restored. Under these conditions, it reduces the content of toxic and reactive aldehydes such as: 4-hydroxy-trans-2-nonenal, malondialdehyde, glyoxal, acrolein and their conjugates with reduced glutathione and carnosine, which are also toxic. Before being excreted from the body, they are reduced by aldose reductase to non-toxic compounds. Thus, the enzyme is one of the components of the body's antioxidant system. Hyperglycemia, which is most pronounced in diabetes, significantly increases the flow of glucose through the sorbitol pathway. The activation of aldosereductase and sorbitol dehydrogenase causes the use of a significant amount of NADPH, which leads to a decrease in antioxidant protection, and the excessive formation of NADH leads to a violation of the ratio of reduced and oxidized forms, known as “pseudohypoxia”. Metabolites of the sorbitol pathway, which are formed in excessive amounts, get toxic effects on metabolism and cellular structures, in particular: sorbitol, as an osmotically active component, causes lens edema, leads to the formation of cataracts, and fructose, fructose-phosphate and 3-deoxyglucasone underlie the pathogenesis of secondary diabetic complications.
Peculiarities of bee breeding influence in mixed form of infectious diseases with varroatosis in the conditions of greenhouse of bees
Authors: Kisil D. O. , Fotina T. I. , Berezovsky A. V. , Nazarenko S. M. , Klishcheva J. E.
Published: November 2020

The article presents data on our study of the epizootiological situation in apiaries with a mixed form of bee diseases in greenhouses of farms in Sumy region. The data showed that of the previously identified infectious diseases of bees, which are one of the most common in the world – it's actually 4–5 major diseases, of which we studied American rot and ascospherosis, which are manifested in a mixed form with varroasis. Effective control of infectious diseases and early preventive work by a beekeeper in apiaries is a guarantee of a prepared strong bee family both for honey collection and preparation of a bee nest for wintering. Earlier, we conducted a study to monitor the epizootic situation of mixed infectious diseases of bees in the north – eastern region of Ukraine, where a large part of the epizootic was due to ascospherosis American and European rot in field work of bees. But in greenhouse conditions, where high humidity and crowding of bees increases the likelihood of damage by both American rot and ascospherosis. Given these factors, there was a suspicion of a synergistic effect of contamination of bee colonies with the above diseases indoors, damp and isolated. Which led us to the necessary detailed study of these diseases in the greenhouse of bee colonies in the Sumy region in the winter – spring periods of 2020. When examining some samples of printed brood, it was found that, with a strong degree of invasion of varroasis, favorable conditions were created for the accumulation of purulent mass at a sufficiently high level when Bac resistance. Larvae White increased to adverse factors and allowed to affect both weakened and healthy larvae, and with low resistance to developing bees associated with extreme greenhouse conditions and the presence of varroa mites, can sometimes affect bee pupae. After analyzing the results of research, we found that varroa mites contribute to the high development of American rot and ascospherosis in all its forms and witness the role of varroa mites as a factor influencing the intensity of the infectious process in closed and open brood of bee nests.
The effectiveness of “Iodozol” in combination therapy in the treatment of postpartum vulvitis in goats
Authors: Sachuk R. M. , Stravsky Ya. S. , Katsaraba O. A. , Ponomareva C. A. , Ostapiv N. V. , Kalynovska L. V. , Kostyshyn Ye. Ie.
Published: November 2020

In the nosology of obstetric pathology of goats a special place is occupied by postpartum lesions of the genitals by pathogenic microflora, of which the lion's share are postpartum vulvitis. The aim of the study was to test a new treatment regimen for postpartum vulvitis in goats and to study the therapeutic efficacy of the drug “Iodozol”, “Celexib” and “Dextrodev 50” in this pathology. Clinical and anamnestic data showed that the symptoms of postpartum vulvitis of goats were characterized by inflammatory edema, high pain, local fever, impaired tissue integrity, hematomas and discharge from the genital tract. Microbiological studies of secretions from the genitals revealed the presence of E. coli, S. aureus, less often – S. saprophyticus and E. faecalis. High resistance of microorganisms to fluoroquinolones and penicillins is noted. E. coli was sensitive to only 35.7 % of antimicrobial drugs, including ceftriaxone, ceftiofur, and iodine. S. aureus is sensitive to 49.9 % of antimicrobial drugs, including ceftriaxone, cephalexin, gentamicin, ceftiofur, iodine (highest sensitivity) and chlorhexidine. S. saprophyticus was insensitive to a number of antibiotics (oxytetracycline, gentamicin, etc.), except iodine. Taking into account microbiological researches the complex scheme of treatment of postpartum vulvitis at goats is developed. Evaluation of the effectiveness of complex therapy of this pathology in animals showed that treatment with “Iodozole”, “Celexib” and “Dextrodev 50” in a short time eliminates inflammatory symptoms (pain, infiltration, redness, discharge). At the end of the course of treatment in the blood was observed an increase in hemoglobin concentration by 13.7 %, a decrease in the number of erythrocytes by 1.7 and leukocytes by 2.2 times compared with treatment. The topical intrauterine drug “Iodozol”, a non-steroidal injectable drug “Celexib”, has been found to have a broad spectrum of antimicrobial activity, and is effective and safe to use. The drugs have an anti-edematous and analgesic effect, and symptomatic treatment with intravenous solution “Dextrodev 50” is a mandatory component of complex therapy and is aimed at replenishing the body with nutrients, as well as helps to neutralize and remove toxins from the body. Further research will be to study the clinical efficacy and develop regulations for the use of this scheme in vulvitis and cervicitis of other ruminants.
Das zweisprachige Gehirn: Gehirnprozesse während des Spracherwerbs
Authors: Gabriotti Rafaela Bepe , Zomignan Rosângela
Published: November 2020

Diese Arbeit ist eine Studie über Spracherwerb, Gehirnprozesse, die während des Erwerbs und Zweisprachigkeit beteiligt sind. Ziel dieser Forschung ist es, besser zu verstehen, wie zwei Sprachen gleichzeitig lernen, damit wir besser darauf vorbereitet sind, Kindern beim Spracherwerb zu helfen, sowie den Lehrer und die Familie durch theoretische Grundlagen zu unterstützen. Aspekte wie die kortikale Organisation der Sprache, Unterschiede zwischen dem zweisprachigen Gehirn im Vergleich zum einsprachigen Gehirn und der Einfluss der sozialen Interaktion auf das sprachliche Lernen werden in dieser Arbeit erläutert, um einen breiten Überblick über den zweisprachigen Spracherwerb zu bieten. Für diese Studie haben wir uns für die bibliographische Forschung ausländischer Literatur entschieden, da im Portugiesischen nicht genügend Materialien gefunden wurden, die die betrachteten Studienbereiche abdeckten. Die Ergebnisse zeigen, wie das Gehirn den Spracherwerb verarbeitet, zeigt den Unterschied zwischen dem gleichzeitigen und sequenziellen Erlernen zweier Sprachen und zeigt, wie soziale Faktoren und Sprache verbunden sind.
Estudo de revisão de efetividade e segurança dos fármacos utilizados na Quimioterapia Intra-arterial no Tratamento do Retinoblastoma
Authors: Canales Inácia Maria da Silva , Ribeiro Alessandra Maximiano , Soares Amata dos Santos , Klingelbt Ingrid , Andreolli Rafael , Santana Claudinei Alves
Published: November 2020

O Retinoblastoma é um tumor maligno característico da infância, o que antes era sinal de enucleação, desde 2005 vem sendo aplicado um tratamento inovador com a quimioterapia intra-arterial que constatou ser efetivo, trazendo bom controle do tumor e complicações sistêmicas mínimas. Pesquisas apresentam resultados de efetividade e segurança desta terapêutica utilizada em alguns países, assim como os principais fármacos utilizados e os resultados positivos no tratamento do retinoblastoma. As informações foram obtidas através de um estudo de revisão na literatura científica, onde se verificou que os fármacos mais utilizados na quimioterapia intra-arterial são o melfalano, a carboplatina e o topotecano. A partir destes resultados podemos concluir que o fármaco de primeira escolha é o melfalano, que pode ser usado em monoterapia ou combinado com carboplatina ou topotecano. Atualmente ainda há estudos em andamento que avaliam a efetividade e segurança do topotecano e da carboplatina na pediatria, sejam em monoterapia ou terapia combinada com outros antineoplásicos.
Toxina Botulínica e Hiperidrose: O uso da neurotoxina no tratamento da doença
Authors: Silva Poliana dos Santos , Xiscatti Valéria Scarlleth Costa , Souza Ramon Guimarães de , Barroso Wermerson Assunção , Oliveira Adriana dos Santos
Published: November 2020

A hiperidrose é uma doença caracterizada pelo distúrbio das glândulas sudoríparas, elevando a produção de suor. O surgimento da doença se dá por diversos fatores, causando aos portadores constrangimento, problemas psicológicos, sociais e emocionais, entre outros. Um dos tratamentos mais atuais para a doença envolve o uso da toxina botulínica tipo A, largamente utilizada em diversos tratamentos médicos e estéticos. Diante disso, o presente trabalho tem como objetivo analisar a literatura acerca do tratamento da hiperidrose com a utilização da toxina botulínica, descrevendo suas propriedades terapêuticas e os mecanismos de ação para combater a doença. A pesquisa se desenvolveu por meio de revisão integrativa da literatura, de caráter exploratória, qualitativa e de natureza indutiva. Os resultados permitiram apontar que a toxina botulínica age impedindo a ativação das glândulas sudoríparas e impedindo a produção de suor, em excesso. Ainda, o tratamento é menos invasivo e mais eficaz que os demais tratamentos clínicos e cirúrgicos, e tem o benefício de apresentar poucos efeitos colaterais.