bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure 3 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations
Authors: Bashi Azadeh C. , Coker Elizabeth A. , Bulusu Krishna C. , Jaaks Patricia , Crafter Claire , Lightfoot Howard , Milo Marta , McCarten Katrina , Jenkins David F. , van der Meer Dieudonne , Lynch James T. , Barthorpe Syd , Andersen Courtney L. , Barry Simon T. , Beck Alexandra , Cidado Justin , Gordon Jacob A. , Hall Caitlin , Hall James , Mali Iman , Mironenko Tatiana , Mongeon Kevin , Morris James , Richardson Laura , Smith Paul D. , Tavana Omid , Tolley Charlotte , Thomas Frances , Willis Brandon S. , Yang Wanjuan , O'Connor Mark J. , McDermott Ultan , Critchlow Susan E. , Drew Lisa , Fawell Stephen E. , Mettetal Jerome T. , Garnett Mathew J.
Published: May 2024

Multi-omics biomarkers of combination activity. A, Schematic of biomarker pipeline including molecular features incorporated and analyses performed. Created with BioRender.com. B, Volcano plot of biomarkers from all analyses. Statistically significant associations are colored by analysis type, nonsignificant biomarkers are colored gray. C, Venn diagrams of the biomarkers from different inputs leading to the identification of emergent biomarkers. Note that single-agent biomarkers may be duplicated for the multiple combinations in which the single agent has been screened: the Venn diagram depicts unique single-agent biomarker associations only. D, Significant enriched pathways for emergent biomarkers in each drug combination category based on Padj values. * 0.05 < P < 0.01, ** 0.01 < P < 0.001, *** P < 0.001. CD, cell death; CS, cell signaling; chemo, chemotherapeutic agents.
Figure S9 from EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth
Authors: Kuhlmann-Hogan Alexandra , Cordes Thekla , Xu Ziyan , Kuna Ramya S. , Traina Kacie A. , Robles-Oteíza Camila , Ayeni Deborah , Kwong Elizabeth M. , Levy Stellar , Globig Anna-Maria , Nobari Matthew M. , Cheng George Z. , Leibel Sandra L. , Homer Robert J. , Shaw Reuben J. , Metallo Christian M. , Politi Katerina , Kaech Susan M.
Published: May 2024

Figure S9: Statins inhibit EGFRmutant tumor cell growth and oncogenic signaling.
Supplementary Table S1 from Cancer Mutations Converge on a Collection of Protein Assemblies to Predict Resistance to Replication Stress
Authors: Zhao Xiaoyu , Singhal Akshat , Park Sungjoon , Kong JungHo , Bachelder Robin , Ideker Trey
Published: May 2024

Table S1 Annotation of NeST assembly.xlsx
Figure S4 from EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth
Authors: Kuhlmann-Hogan Alexandra , Cordes Thekla , Xu Ziyan , Kuna Ramya S. , Traina Kacie A. , Robles-Oteíza Camila , Ayeni Deborah , Kwong Elizabeth M. , Levy Stellar , Globig Anna-Maria , Nobari Matthew M. , Cheng George Z. , Leibel Sandra L. , Homer Robert J. , Shaw Reuben J. , Metallo Christian M. , Politi Katerina , Kaech Susan M.
Published: May 2024

Figure S4: Deficiency of PPARγ in CSF1R- or CD11c-expressing cells suppresses tumor growth. 
Figure S3 from EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth
Authors: Kuhlmann-Hogan Alexandra , Cordes Thekla , Xu Ziyan , Kuna Ramya S. , Traina Kacie A. , Robles-Oteíza Camila , Ayeni Deborah , Kwong Elizabeth M. , Levy Stellar , Globig Anna-Maria , Nobari Matthew M. , Cheng George Z. , Leibel Sandra L. , Homer Robert J. , Shaw Reuben J. , Metallo Christian M. , Politi Katerina , Kaech Susan M.
Published: May 2024

Figure S3. Lipid import from myeloid cells in the TME.
Data from Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers
Authors: Rubinson Douglas A. , Tanaka Noritaka , Fece de la Cruz Ferran , Kapner Kevin S. , Rosenthal Michael H. , Norden Bryanna L. , Barnes Haley , Ehnstrom Sara , Morales-Giron Alvin A. , Brais Lauren K. , Lemke Christopher T. , Aguirre Andrew J. , Corcoran Ryan B.
Published: May 2024

Abstract
KRASG12C inhibitors, like sotorasib and adagrasib, potently and selectively inhibit KRASG12C through a covalent interaction with the mutant cysteine, driving clinical efficacy in KRASG12C tumors. Because amino acid sequences of the three main RAS isoforms—KRAS, NRAS, and HRAS—are highly similar, we hypothesized that some KRASG12C inhibitors might also target NRASG12C and/or HRASG12C, which are less common but critical oncogenic driver mutations in some tumors. Although some inhibitors, like adagrasib, were highly selective for KRASG12C, others also potently inhibited NRASG12C and/or HRASG12C. Notably, sotorasib was five-fold more potent against NRASG12C compared with KRASG12C or HRASG12C. Structural and reciprocal mutagenesis studies suggested that differences in isoform-specific binding are mediated by a single amino acid: Histidine-95 in KRAS (Leucine-95 in NRAS). A patient with NRASG12C colorectal cancer treated with sotorasib and the anti-EGFR antibody panitumumab achieved a marked tumor response, demonstrating that sotorasib can be clinically effective in NRASG12C-mutated tumors.
Significance:
These studies demonstrate that certain KRASG12C inhibitors effectively target all RASG12C mutations and that sotorasib specifically is a potent NRASG12C inhibitor capable of driving clinical responses. These findings have important implications for the treatment of patients with NRASG12C or HRASG12C cancers and could guide design of NRAS or HRAS inhibitors.

See related commentary by Seale and Misale, p. 698.

This article is featured in Selected Articles from This Issue, p. 695
Data from Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
Authors: Rosano Dalia , Sofyali Emre , Dhiman Heena , Ghirardi Chiara , Ivanoiu Diana , Heide Timon , Vingiani Andrea , Bertolotti Alessia , Pruneri Giancarlo , Canale Eleonora , Dewhurst Hannah F. , Saha Debjani , Slaven Neil , Barozzi Iros , Li Tong , Zemlyanskiy Grigory , Phillips Henry , James Chela , Győrffy Balázs , Lynn Claire , Cresswell George D. , Rehman Farah , Noberini Roberta , Bonaldi Tiziana , Sottoriva Andrea , Magnani Luca
Published: May 2024

Abstract
Patients with estrogen receptor–positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients relapse even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic and transcriptional changes underlying tumor awakening, we analyzed late relapse patients and longitudinally profiled a rare cohort treated with long-term neoadjuvant ETs until progression. Next, we developed an in vitro evolutionary study to record the adaptive strategies of individual lineages in unperturbed parallel experiments. Our data demonstrate that ETs induce nongenetic cell state transitions into dormancy in a stochastic subset of cells via epigenetic reprogramming. Single lineages with divergent phenotypes awaken unpredictably in the absence of recurrent genetic alterations. Targeting the dormant epigenome shows promising activity against adapting cancer cells. Overall, this study uncovers the contribution of epigenetic adaptation to the evolution of resistance to ETs.
Significance:
This study advances the understanding of therapy-induced dormancy with potential clinical implications for breast cancer. Estrogen receptor-positive breast cancer cells adapt to endocrine treatment by entering a dormant state characterized by strong heterochromatinization with no recurrent genetic changes. Targeting the epigenetic rewiring impairs the adaptation of cancer cells to ETs.

See related commentary by Llinas-Bertran et al., p. 704.

This article is featured in Selected Articles from This Issue, p. 695
Supplementary Tables 1-11 from Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis
Authors: Saygin Caner , Zhang Pu , Stauber Jacob , Aldoss Ibrahim , Sperling Adam S. , Weeks Lachelle D. , Luskin Marlise R. , Knepper Todd C. , Wanjari Pankhuri , Wang Peng , Lager Angela M. , Fitzpatrick Carrie , Segal Jeremy P. , Gharghabi Mehdi , Gurbuxani Sandeep , Venkataraman Girish , Cheng Jason X. , Eisfelder Bart J. , Bohorquez Oliver , Patel Anand A. , Umesh Nagalakshmi Sheethal , Jayaram Savita , Odenike Olatoyosi M. , Larson Richard A. , Godley Lucy A. , Arber Daniel A. , Gibson Christopher J. , Munshi Nikhil C. , Marcucci Guido , Ebert Benjamin L. , Greally John M. , Steidl Ulrich , Lapalombella Rosa , Shah Bijal D. , Stock Wendy
Published: May 2024

Supplemental Table 1. List of DNA gene mutations tested in diagnostic tumor samples of our ALL cohort.

Supplemental Table 2. List of 80 genes with RNA sequencing coverage.

Supplemental Table 3. Demographics of 400 adult ALL cases.

Supplemental Table 4. List of first-line (initial) therapies in Ph-positive B-ALL, Ph-negative B-ALL, and Tlineage ALL patients.

Supplemental Table 5. Baseline gene rearrangements and structural variants of 329 molecularly characterized adult B-ALL patients.

Supplemental Table 6. Baseline gene rearrangements and structural variants of 71 molecularly characterized adult T-lineage ALL patients.

Supplemental Table 7. List of pathogenic/likely pathogenic germline variants in our ALL cohort.

Supplementary Table 8. Multivariable analysis of overall survival (OS) in B-ALL patients.

Supplemental Table 9. Clinical characteristics of patients studied in scDNA + protein sequencing experiments.

Supplemental Table 10. Clinical characteristics of patients studied in scRNA-seq experiment.

Supplemental Table 11. Ingenuity pathway analysis comparing B-lymphoblasts from B-ALL with MyM vs B-ALL without MyM.
Table S3 from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Authors: Olesinski Elyse A. , Bhatia Karanpreet Singh , Wang Chuqi , Pioso Marissa S. , Lin Xiao Xian , Mamdouh Ahmed M. , Ng Shu Xuan , Sandhu Vedant , Jasdanwala Shaista Shabbir , Yilma Binyam , Bohl Stephan , Ryan Jeremy A. , Malani Disha , Luskin Marlise R. , Kallioniemi Olli , Porkka Kimmo , Adamia Sophia , Chng Wee Joo , Osato Motomi , Weinstock David M. , Garcia Jacqueline S. , Letai Anthony , Bhatt Shruti
Published: May 2024

Supplemental Table 3 shows overlapping gene sets contributing to KEGG pathway enrichment between acquired resistant PDX models and relapsed AML patients.
Figure S5 from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Authors: Olesinski Elyse A. , Bhatia Karanpreet Singh , Wang Chuqi , Pioso Marissa S. , Lin Xiao Xian , Mamdouh Ahmed M. , Ng Shu Xuan , Sandhu Vedant , Jasdanwala Shaista Shabbir , Yilma Binyam , Bohl Stephan , Ryan Jeremy A. , Malani Disha , Luskin Marlise R. , Kallioniemi Olli , Porkka Kimmo , Adamia Sophia , Chng Wee Joo , Osato Motomi , Weinstock David M. , Garcia Jacqueline S. , Letai Anthony , Bhatt Shruti
Published: May 2024

Supplemental Figure 5 shows DBP identified drug sensitivities in resistant vs parental AML PDX models.
Supplementary Tables 1-5 from Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119
Authors: Köhnke Thomas , Nuno Kevin A. , Alder Catherine C. , Gars Eric J. , Phan Paul , Fan Amy C. , Majeti Ravindra
Published: May 2024

Supplementary Tables 1 - 5.
Data from Spatial Mapping of Hematopoietic Clones in Human Bone Marrow
Authors: Young Andrew L. , Davis Hannah C. , Cox Maggie J. , Parsons Tyler M. , Burkart Samantha C. , Bender Diane E. , Sun Lulu , Oh Stephen T. , Challen Grant A.
Published: May 2024

Abstract
Clonal hematopoiesis (CH) is the expansion of somatically mutated cells in the hematopoietic compartment of individuals without hematopoietic dysfunction. Large CH clones (i.e., >2% variant allele fraction) predispose to hematologic malignancy, but CH is detected at lower levels in nearly all middle-aged individuals. Prior work has extensively characterized CH in peripheral blood, but the spatial distribution of hematopoietic clones in human bone marrow is largely undescribed. To understand CH at this level, we developed a method for spatially aware somatic mutation profiling and characterized the bone marrow of a patient with polycythemia vera. We identified the complex clonal distribution of somatic mutations in the hematopoietic compartment, the restriction of somatic mutations to specific subpopulations of hematopoietic cells, and spatial constraints of these clones in the bone marrow. This proof of principle paves the way to answering fundamental questions regarding CH spatial organization and factors driving CH expansion and malignant transformation in the bone marrow.
Significance:
CH occurs commonly in humans and can predispose to hematologic malignancy. Although well characterized in blood, it is poorly understood how clones are spatially distributed in the bone marrow. To answer this, we developed methods for spatially aware somatic mutation profiling to describe clonal heterogeneity in human bone marrow.

See related commentary by Austin and Aifantis, p. 139.
Data from Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119
Authors: Köhnke Thomas , Nuno Kevin A. , Alder Catherine C. , Gars Eric J. , Phan Paul , Fan Amy C. , Majeti Ravindra
Published: May 2024

Abstract
Mutations in additional sex combs like 1 (ASXL1) confer poor prognosis both in myeloid malignancies and in premalignant clonal hematopoiesis (CH). However, the mechanisms by which these mutations contribute to disease initiation remain unresolved, and mutation-specific targeting has remained elusive. To address this, we developed a human disease model that recapitulates the disease trajectory from ASXL1-mutant CH to lethal myeloid malignancy. We demonstrate that mutations in ASXL1 lead to the expression of a functional, truncated protein and determine that truncated ASXL1 leads to global redistribution of the repressive chromatin mark H2AK119Ub, increased transposase-accessible chromatin, and activation of both myeloid and stem cell gene-expression programs. Finally, we demonstrate that H2AK119Ub levels are tied to truncated ASXL1 expression levels and leverage this observation to demonstrate that inhibition of the PRC1 complex might be an ASXL1-mutant–specific therapeutic vulnerability in both premalignant CH and myeloid malignancy.
Significance:
Mutant ASXL1 is a common driver of CH and myeloid malignancy. Using primary human HSPCs, we determine that truncated ASXL1 leads to redistribution of H2AK119Ub and may affect therapeutic vulnerability to PRC1 inhibition.
Meningites purulentas
Authors: Bittencourt José Mário Tacques
Published: May 2024

O sucesso da terapêutica nas meningites bacterianas depende da observância de três normas. A primeira determina o início precoce do tratamento. O diagnóstico clínico nas pessoas com mais de um ano de idade e que não tinham sido medicadas anteriormente é fácil pela presença dos sinais das síndromes infecciosa, hipertensiva intracraniana e radicular antálgica. Nas crianças com menos de um ano, o diagnóstico é difícil pela falta de qualquer sinal ou conjunto de sinais que, pela sua constância, possam servir de base para o raciocínio. Nesses casos é aconselhável praticar exame do líquido cefalorraqueano todas as vezes que um processo infeccioso grave permanecer sem diagnóstico após três dias de evolução. É o exame do líquido cefalorraqueano que comprova o diagnóstico das meningites bacterianas: a hipercitose com inversão da fórmula leucocitária, a queda das taxas de cloretos e glicose e a possívelpresença do germe ao exame bacterioscópico ou na cultura.A segunda norma determina o uso de antibiótico e de quimioterápico emdoses suficientes para alcançar rapidamente níveis terapêuticos. Antes de obtido o antibiograma e determinado o agente terapêutico específico, aconselha-se o uso de sulfadiazina 0,2 g/kg de peso ao dia, penicilina 1 a 2 milhões de unidades cada 3 ou 4 horas e cloranfenicol 0,5 a 1 g cada 12 horas. O uso da via intratecal é aconselhado nos casos em que se deseja o efeito imediato da medicação e em que a espera de 6 ou 8 horas, necessárias para o medicamento alcançar níveis terapêuticos no líquido cefalorraqueano, seja desaconselhada.A terceira norma determina a duração da terapêutica até a eliminaçãocompleta do agente infeccioso. Só suspender a medicação quando todos os sinais clínicos e laboratoriais indicarem que a infecção foi eliminada.
Resultado do tratamento cirúrgico das cardiopatias congênitas acianóticas
Authors: Stolf Noedir Antonio Groppo , Moreira Luiz Felipe Pinho , Pêgo-Fernandes Paulo Manuel
Published: May 2024

Os autores realizam análise dos resultados do tratamento cirúrgico das cardiopatias congênitas acianóticas. Consideram em separado as anomalias mais freqüentes: coartação da aorta, estenoses aórticas, estenoses pulmonares, comunicação interatrial, "atrioventricularis comunis", comunicação interventricular e persistência do canal arterial. Objetivando o estudo dos resultados tardios dessas cardiopatias comentam aspectos operatórios que podem se relacionar com a evolução tardia.
Uma proposta da Liga de Cirurgia Ambulatorial CAOC/3º CC
Authors: Junqueira Jr. Aldo , Takeuti Milton Minoru , Szajnbok Israel , Kamikawa Janete , Lin Oscar , Yamamuro Elisa Miki
Published: May 2024

A Liga de Cirurgia Ambulatorial do CAOC/33ª CC foi fundada no ano de 1983 e objetiva promover o aprendizado e treinamento dos acadêmicos da FMUSP na prática cirúrgica. Este mister somente pode ser atingido se forem obedecidas condutas normativas previamente traçadas.Desde o início, a preocupação com a seleção dos casos a serem submetidos a intervenções cirúrgicas no ambulatório é fator fundamental no sentido de propiciar segurança e cuidados médicos criteriosos ao paciente. No presente trabalho é apresentado o protocolo seguido e obedecido pelos acadêmicos ao avaliarem clinicamente os pacientes triados para cirurgia ambulatorial.Além das normas, são discutidos aspectos dessa avaliação e as tendências da literatura que fornecem o necessário embasamento e justificam essas normas.Na Liga de Cirurgia Ambulatorial do CAOC/3ªCC, atualmente, são realizadas 10 intervenções cirúrgicas por semana.
Don Juan, herói da modernidade
Authors: Bretas Aléxia
Published: May 2024

If Benjamin is right when he assures that to live Modernity it is required an heroic constitution, the figure of Don Juan is perfectly apt to that. From Tirso de Molina to José Saramago, passing by Molière, Mozart, Hoffmann, Balzac, Baudelaire and Camus, this serial lover condemned to hell has crossed the centuries without losing his breath or not being modern. As dandy, libertine, dissolute, conqueror, reflexive seducer, absurd man or simply Giovanni, his attitude is usually based on the law which gives him the reputation of trickster from Sevilla: the refusal in accepting the Ecclesiasts moral teachings as life conduct.
Characteristics of Right-Sided Accessory Pathways Associated With Right Cardiac Veins
Authors: Lai Yiwei , Gao Mingyang , Li Qifan , Li Mengmeng , Zhang Jianghua , Li Xuexun , Guo Qi , Huang Lihong , Jiang Chenxi , Li Songnan , Guo Xueyuan , Zuo Song , Liu Nian , Wang Wei , Zhao Xin , Sang Caihua , Tang Ribo , Long Deyong , Dong Jianzeng , Ma Changsheng
Published: May 2024

BACKGROUND:

The anatomy of myocardial fibers around the right cardiac veins (RCVs) and their roles in accessory pathways (APs) are rarely reported.

METHODS:

Six RCV-APs were identified from 566 patients with right-sided APs. Mapping of retrograde atrial activation was performed using CARTO 3 system under orthodromic tachycardia or right ventricular pacing. Venography of RCVs was acquired at the earliest retrograde atrial activation.

RESULTS:

Patients enrolled had a median age of 30 (11–51) years, 5 of them were male. Venography of RCVs could be classified into 3 distinct patterns based on the identified ventricular branches, right marginal vein only (type I; n=3), both right marginal vein and anterior cardiac veins (type II; n=2), and anterior cardiac vein only (type III; n=1). Patients with type I venography had rS QRS pattern in lead V
1
, negative delta wave in lead III and negative or isoelectric delta wave in lead aVF. However, patients with type II and III venography had QS QRS patterns in lead V
1
and variable patterns of delta wave in inferior leads. Earliest retrograde atrial activation was found at a median of 16.75 (14.60–20.00) mm away from the tricuspid annulus, all with A larger than V. At the earliest retrograde atrial activation, far-field ventricular electrogram was found 30 ms later than QRS onset in 1 patient under sinus rhythm. AP conduction was eliminated by mechanical pressure in 2 and by radiofrequency ablation in 4 at the ostium of the veins colocalizing with the earliest retrograde activation of the right atrium. No recurrence was observed during 36 (10–60) months follow-up.

CONCLUSIONS:

The RCV-AP is a rare form of right-sided APs characterized by atrial insertions distant from the annulus. ECG-speculated ventricular insertion sites conformed to the location of identified RCVs.
Association of Incident Stroke Risk With an IL-18-Centered Inflammatory Network Biomarker Composite
Authors: Martirosian Richard A. , Wiedner Crystal D. , Sanchez Jasmin , Mun Katherine T. , Marla Kiran , Teran Cristina , Thirion Marissa , Liebeskind David S. , McGrath Emer R. , Zucker Jared M. , Bernal Rebecca , Beiser Alexa S. , DeCarli Charles , Himali Jayandra J. , Seshadri Sudha , Hinman Jason D.
Published: May 2024

BACKGROUND:

A coordinated network of circulating inflammatory molecules centered on the pleotropic pro-atherogenic cytokine interleukin-18 (IL-18) is linked to cerebral small vessel disease. We sought to validate the association of this inflammatory biomarker network with incident stroke risk, cognitive impairment, and imaging metrics in a sample of the Framingham Offspring Cohort.

METHODS:

Using available baseline measurements of serum levels of IL-18, GDF (growth and differentiation factor)-15, soluble form of receptor for advanced glycation end products, myeloperoxidase, and MCP-1 (monocyte chemoattractant protein-1) from Exam 7 of the Framingham Offspring Cohort (1998–2001), we constructed a population-normalized, equally weighted log-transformed mean
Z
-score value representing the average level of each serum analyte to create an inflammatory composite score (ICS5). Multivariable regression models were used to determine the association of ICS5 with incident stroke, brain magnetic resonance imaging features, and cognitive testing performance.

RESULTS:

We found a significant association between ICS5 score and increased risk for incident all-cause stroke (hazard ratio, 1.48 [95% CI, 1.05–2.08];
P
=0.024) and ischemic stroke (hazard ratio, 1.51 [95% CI, 1.03–2.21];
P
=0.033) in the Exam 7 cohort of 2201 subjects (mean age 62±9 years; 54% female) aged 45+ years with an all-cause incident stroke rate of 6.1% (135/2201) and ischemic stroke rate of 4.9% (108/2201). ICS5 and its component serum markers are all associated with the Framingham Stroke Risk Profile score (β±SE, 0.19±0.02;
P
<0.0001). In addition, we found a significant inverse association of ICS5 with a global cognitive score, derived from a principal components analysis of the neuropsychological battery used in the Framingham cohort (−0.08±0.03;
P
=0.019). No association of ICS5 with magnetic resonance imaging metrics of cerebral small vessel disease was observed.

CONCLUSIONS:

Circulating serum levels of inflammatory biomarkers centered on IL-18 are associated with an increased risk of stroke and cognitive impairment in the Framingham Offspring Cohort. Linking specific inflammatory pathways to cerebral small vessel disease may enhance individualized quantitative risk assessment for future stroke and vascular cognitive impairment.
Trafficking Captives in South America’s Southern Cone
Authors: Martínez Barraza Juan José , Cussen Celia
Published: May 2024

This article demonstrates the logic, efficacy and profitability of the commerce in enslaved persons between Rio de la Plata and Lima from the late 1760s to the second decade of the nineteenth century. Moving beyond the customary study of local markets, it combines newly located tax, custom and notarial records with recent studies to describe the intercontinental slave trade in the Southern Cone. It demonstrates how Lima’s demand for labor lay behind the transportation of more than 25,000 enslaved persons over the pampas and across the Andes to the port of Valparaiso, for final delivery in Lima’s port of Callao. We find that most of the trafficking was concentrated in the summer and fall, consisted of the transportation of fewer than four slaves at a time, and was undertaken by hundreds of actors playing a variety of commercial roles.
Beyond Slavery and Freedom?
Authors: Wimmler Jutta , Wiegmink Pia
Published: May 2024

This introductory essay to the special issue Beyond Slavery and Freedom? makes concrete suggestions how we might move beyond this binary and why we should do so. The introduction argues that the conceptual pair slavery/freedom is deeply entwined with narratives of modernity and progress and has shaped scholarship in very diverse fields. On the basis of empirical research from the Bonn Center for Dependency and Slavery Studies (BCDSS), we identify six possible pathways of thematically and methodologically moving beyond slavery/freedom that the contributions to the special issue address: 1) investigating forms of dependency that are not usually defined as slavery, 2) paying attention to semantic fields that are closely connected to this binary but not usually understood in relation to it, 3) highlighting the connection between (political, institutional) power and dependency, 4) engaging with post-slavery periods and experiences, 5) problematizing the challenges of identifying slavery in non-written records, and 6) underscoring the voice of actors.
Serving toward Release
Authors: Kloß Sinah T.
Published: May 2024

Autonomy is not universally considered the basis of agency in all cultural and historical contexts, nor is it always seen as a prerequisite to “freedom” and “liberation,” standing in conceptual opposite to coercion. In Caribbean Hindu contexts, the notion of service (sevā) as a form of (religious) work is aimed at decentering and dissolving the self for ultimate release from worldly suffering. Historically, regarding post-indenture Suriname and Guyana, some social actors understood godnas—the tattoos of especially senior Hindu women who identified as descendants of Indian indentured laborers—as a means of capacitating women and female bodies toward this goal by allowing them to conduct religious work. Some women with these tattoos considered godnas as voluntary and enabling. Their interpretations diverged from contemporary discourse, which links these tattoos to a presumed compulsory Hindu tradition that subjugated wives to husbands and in-laws. These varied assessments along a continuum of coercion and voluntariness highlight a continued focus on the conceptual binary that (un-)freedom obscures other relevant aspects of the (indentured) workers’ experiences. It runs the risk of reproducing Eurocentric notions of freedom, coercion, and work/labor, shrouding the pertinence of spiritual capital and (religious) rewards in analyses of coercive practices and structural violence.
Between Liberation and Recoercion
Authors: Smolarz Elena
Published: May 2024

Drawing on official imperial discourses in the Russian Empire and archival documents of the Orenburg Border Commission (1799–1856), the Russian imperial administrative institution subordinated to the Ministry of Foreign Affairs, this paper analyzes the ransoming, release, and reintegration of freed Russian subjects and shows how these processes and practices were inextricably linked to the Russian imperial concept of political belonging. In such a context, the concepts of freedom and liberation must be questioned; that is, we must determine the extent to which “freedom” can represent a universal value and is legally defined and thus dependent on sociopolitical situations and frameworks. To contribute to a more precise and multifaceted understanding of “freedom” and “dependency” as well as “freeing” and “enslavement,” this article examines the liberation and repatriation of enslaved Russian subjects in the Central Asian khanates of Khiva and Bukhara in the first half of the nineteenth century.
Establish Shared Visions and Support Productive Adaptations on All Levels
Authors: Prediger Susanne , Selter Christoph
Published: May 2024

Large-scale implementation programs for mathematics education innovations should combine several implementation strategies and span over several levels: the mathematics classroom level, the teacher professional development (PD) level, and the facilitator PD level, as well as over the systemic contexts on each of these levels. In this paper, we present the strategies and program architecture of the German nationwide 10-year implementation program QuaMath, which aims at developing the quality of mathematics classrooms and teacher PD in cooperation with the federal states, 400 PD facilitators, and, prospectively, 10000 schools. Given the spread of intended implementation and the depth of the targeted instructional innovations, we also outline the general philosophy of establishing shared visions with all stakeholders and support their productive adaptations at the same time. This philosophy also underpins the planned implementation design research in the program.

The impact sheet to this article can be accessed at 10.6084/m9.figshare.25507138.
Anthologies of Persian Poetry Inscribed in Indonesia: A Handlist of Rare Manuscripts
Authors: Daneshgar Majid
Published: May 2024

This article is about seven rare manuscripts copied in Indonesia from the 15th–19th centuries. They include Persian poetic collections and musical modes, occasionally mixed with Hindi and Turkic phrases. This handlist is an introduction to the reception and circulation of Persianate texts in the Malay-Indonesian world for about five hundred years.
Peucela acutativalva Qi & Li, 2020 (Lepidoptera: Pyralidae): An addition to the Indian fauna
Authors: LOTANI NARENDRA SINGH , NEGI CHANDRA SINGH
Published: May 2024

Peucela acutativalva Qi & Li, 2020 is reported from the Kumaon Himalaya, Uttarakhand, India. The specimens examined are slightly different from those described by Qi et al. (2020). These differences are discussed.
Study on the intraspecific variation of Capila lineata lineata Chou & Gu, 1994, with some taxonomic notes on the related taxa (Hesperiidae, Pyrginae)
Authors: XUE GUOXI , XIE YUNXIAO , SHEN GUANGCAI , LI XIAOJUAN , LI MENG , GUO YINGCHENG
Published: May 2024

The history with regard to questions on Capila lineata lineata Chou & Gu, 1994, C. lineata magna Devyatkin & Monastyrskii, 1999, C. lineata irregularis Devyatkin & Monastyrskii, 2002 and C. neolineata Fan, Wang & Huang, 2003 was reviewed. The intraspecific variation of C. lineata lineata was explored by DNA barcoding and morphological comparison. The results revealed a remarkable variability in wing patterns and a slight variability in female genitalia, whereas characters of the male genitalia were uniform. C. lineata irregularis syn. n. and C. neolineata syn. n. are treated as junior subjective synonyms of C. lineata lineata because morphological characters of the two taxa fall into the range of individual variation of the latter.
Evaluation Method for Seismic Toughness of Steel Frame Buildings with Buckling Constraint Braces Based on the Whole Construction Process
Authors: Chen Liang-Jin
Published: May 2024

As a common building structure, steel frame building is of great significance in seismic design and construction in earthquake areas. However, the traditional steel frame structure is brittle under earthquake, which is prone to buckling instability and serious damage. Therefore, taking
the whole construction process as a parameter index, the buckling-restrained brace-steel frame structure is strengthened, and different seismic waves are selected as seismic input to analyze and study its seismic capacity under earthquake action. The research results show that: (1) The steel
frame with buckling-restrained braces still has strong seismic toughness when there is a large stiffness loss in the earthquake; (2) The base shear curve of building buckling-restrained brace-steel frame in X direction increases exponentially; (3) Buckling-restrained brace-steel frame
has high shear force shared by columns and axes in X direction under strong earthquake, which can effectively realize the function of secondary protection; (4) The short duration of strong earthquake has little influence on the hysteretic energy consumption ratio, while the damage of
the long duration of strong earthquake to the building buckling restrained brace-steel frame increases with the increase of strong earthquake duration; (5) Buckling restrained brace-steel frame has good deformability and can adapt to earthquake load through plastic deformation
Enhanced Photodegradation of Methylene Blue Using Reusable Cobalt Ferrite Nanocomposites
Authors: Chavan Rupali , Mujawar Sarfraj , Dawkar Vishal , More Vishalkumar , Pawar Nilesh , Patil Rahul , Jadhav Jyoti , Mustafa Jawed , Jameel Basrat , Muhaisen Hasan M. H. , Mohammed Ayeda Y. A. , Chougale Ashok
Published: May 2024

Growing industrialization is contributing to the worsening shortage of potable water in society. Consequently, wastewater treatment and dye degradation become the foremost aim to overcome this problem. Magnetic nanoparticles (MNPs) emerged as an efficient tool to overcome the problem
of wastewater treatment. Easy recovery of the MNPs reduces the operational cost of the reaction. Therefore, in the current study simple, cheap, green, and highly proficient synthesis methodology for the magnetically recoverable cobalt ferrite is reported. The X-ray diffraction spectroscopy
(XRD) and Fourier transform infrared spectroscopy (FTIR) confirm the crystalline structure and functional group on the synthesized nanoparticles. The elemental composition, surface morphology, and surface area were investigated by Energy-dispersive X-ray spectroscopy (EDS), Field emission
scanning electron microscopy (FESEM), and Brunauer-Emmett-Teller (BET) analysis. The Photo-Fenton process was used to check the catalytic activity of the prepared CoFe2O4 nanoparticles (NPs). The effect of the various experimental parameters like pH (3–9), catalyst
dosage (50–200 mg/L), H2O2 dosage (5–20 mM), and varied dye (methylene blue) concentration (0.05–0.2 mM) on catalytic performance were studied. According to this investigation, 90% degradation of the methylene blue was achieved in just 90 minutes using
the assynthesized catalyst. The catalyst showed 76.91% of the dye degradation even after 4 consecutive cycles; it suggests the admirable stability of the catalyst during the reaction. The robustness of the CoFe2O4 NPs makes it potential candidate for the waste water treatment.
Green Finance Initiatives to Improve Green Banking Practices in India
Authors: Umamaheswari S. , Elangovan A.
Published: May 2024

Green finance is an innovative financial system. It is an umbrella term comprising green agriculture, green marketing, green building, green banking, green energy, and environmental friendly projects. It is an important sector of green finance. Global warming and climate change are the biggest problems throughout the world, which start to take their toll. To overcome these problems, to verify the existing business models and to learn clean development mechanisms through adopting clean development mechanism (CDM) projects, new financing models are essential. Green finance helps to protect common and green-ecological factors which intend to save and look after natural resources. Nature’s resources are saved and produced through green baking practices. Green banking practices refer to environmentally sustainable banking practices, which reduce the environmental impact of financial institutions while promoting environmentally friendly activities. This article’s goal is to examine green banking practices. The function and contribution of banks to environmental sustainability are also covered in this study. In the manuscript an effort has been geared up to study the objectives of the green finance related to green banking practices in our country, to analyze the green financial products and to get know the upcoming opportunity of green finance with regard to regulatory and policy frameworks for green banking. This article only focused on secondary data and focused on present and future renewable energy capacity used for this manuscript and explores ways to strengthen these frameworks to promote the growth of the green economy.
Predictors of basic and instrumental activities of daily living among older adults with multiple chronic conditions
Authors: Jafari-Koulaee Azar , Mohammadi Eesa , Fox Mary T. , Rasekhi Aliakbar , Akha Ozra
Published: May 2024

Background

Understanding the predictors of functional status can be useful for improving modifiable predictors or identifying at-risk populations. Researchers have examined the predictors of functional status in older adults, but there has not been sufficient study in this field in older adults with multiple chronic conditions, especially in Iran. Consequently, the results of this body of research may not be generalizable to Iran. Therefore, this study was conducted to determine the predictors of functional status in Iranian older adults with multiple chronic conditions.

Methods

In this cross-sectional study, 118 Iranian older adults with multiple chronic conditions were recruited from December 2022 to September 2023. They were invited to respond to questionnaires inquiring about their demographic and health information, basic activities of daily living (BADL) and instrumental activities of daily living (IADL), depression and cognitive status. The predictors included age, gender, marital status, education, number of chronic conditions, and depression. Descriptive and analytical statistical tests (univariate and multiple regression analysis) were used to analyze the data.

Results

The majority of participants were married (63.9%) and women (59.3%). Based on the results of the multiple regression analysis, age (B=-0.04, P = 0.04), depression (B=-0.12, P = 0.04), and IADL (B = 0.46, P < 0.001) were significant predictors for functional status in terms of BADL. Also, marital status (B=-0.51, P = 0.05), numbers of chronic conditions (B=-0.61, P = 0.002), and BADL (B = 0.46, P < 0.001) were significant predictors for functional status in terms of IADL.

Conclusion

The findings support the predictive ability of age, marital status, number of chronic diseases, and depression for the functional status. Older adults with multiple chronic conditions who are older, single, depressed and with more chronic conditions number are more likely to have limitations in functional status. Therefore, nurses and other health care providers can benefit from the results of this study and identify and pay more attention to the high risk older adult population.
Triglyceride-glucose index as a potential predictor for in-hospital mortality in critically ill patients with intracerebral hemorrhage: a multicenter, case–control study
Authors: Yang Yang , Liang Shengru , Liu Jiangdong , Man Minghao , Si Yue , Jia Dengfeng , Li Jianwei , Tian Xiaoxi , Li Lihong
Published: May 2024

Background

The correlation between the triglyceride-glucose index (TyG) and the prognosis of ischemic stroke has been well established. This study aims to assess the influence of the TyG index on the clinical outcomes of critically ill individuals suffering from intracerebral hemorrhage (ICH).

Methods

Patients diagnosed with ICH were retrospectively retrieved from the Medical Information Mart for Intensive Care (MIMIC-IV) and the eICU Collaborative Research Database (eICU-CRD). Various statistical methods, including restricted cubic spline (RCS) regression, multivariable logistic regression, subgroup analysis, and sensitivity analysis, were employed to examine the relationship between the TyG index and the primary outcomes of ICH.

Results

A total of 791 patients from MIMIC-IV and 1,113 ones from eICU-CRD were analyzed. In MIMIC-IV, the in-hospital and ICU mortality rates were 14% and 10%, respectively, while in eICU-CRD, they were 16% and 8%. Results of the RCS regression revealed a consistent linear relationship between the TyG index and the risk of in-hospital and ICU mortality across the entire study population of both databases. Logistic regression analysis revealed a significant positive association between the TyG index and the likelihood of in-hospital and ICU death among ICH patients in both databases. Subgroup and sensitivity analysis further revealed an interaction between patients' age and the TyG index in relation to in-hospital and ICU mortality among ICH patients. Notably, for patients over 60 years old, the association between the TyG index and the risk of in-hospital and ICU mortality was more pronounced compared to the overall study population in both MIMIC-IV and eICU-CRD databases, suggesting a synergistic effect between old age (over 60 years) and the TyG index on the in-hospital and ICU mortality of patients with ICH.

Conclusions

This study established a positive correlation between the TyG index and the risk of in-hospital and ICU mortality in patients over 60 years who diagnosed with ICH, suggesting that the TyG index holds promise as an indicator for risk stratification in this patient population.
Associations of sleep disorders with serum neurofilament light chain levels in Parkinson’s disease
Authors: Qi Wan-Yi , Sun Yan , Guo Yun , Tan Lan
Published: May 2024

Background

Sleep disorders are a prevalent non-motor symptom of Parkinson’s disease (PD), although reliable biological markers are presently lacking.

Objectives

To explore the associations between sleep disorders and serum neurofilament light chain (NfL) levels in individuals with prodromal and early PD.

Methods

The study contained 1113 participants, including 585 early PD individuals, 353 prodromal PD individuals, and 175 healthy controls (HCs). The correlations between sleep disorders (including rapid eye movement sleep behavior disorder (RBD) and excessive daytime sleepiness (EDS)) and serum NfL levels were researched using multiple linear regression models and linear mixed-effects models. We further investigated the correlations between the rates of changes in daytime sleepiness and serum NfL levels using multiple linear regression models.

Results

In baseline analysis, early and prodromal PD individuals who manifested specific behaviors of RBD showed significantly higher levels of serum NfL. Specifically, early PD individuals who experienced nocturnal dream behaviors (β = 0.033; P = 0.042) and movements of arms or legs during sleep (β = 0.027; P = 0.049) showed significantly higher serum NfL levels. For prodromal PD individuals, serum NfL levels were significantly higher in individuals suffering from disturbed sleep (β = 0.038; P = 0.026). Our longitudinal findings support these baseline associations. Serum NfL levels showed an upward trend in early PD individuals who had a higher total RBDSQ score (β = 0.002; P = 0.011) or who were considered as probable RBD (β = 0.012; P = 0.009) or who exhibited behaviors on several sub-items of the RBDSQ. In addition, early PD individuals who had a high total ESS score (β = 0.001; P = 0.012) or who were regarded to have EDS (β = 0.013; P = 0.007) or who exhibited daytime sleepiness in several conditions had a trend toward higher serum NfL levels.

Conclusion

Sleep disorders correlate with higher serum NfL, suggesting a link to PD neuronal damage. Early identification of sleep disorders and NfL monitoring are pivotal in detecting at-risk PD patients promptly, allowing for timely intervention. Regular monitoring of NfL levels holds promise for tracking both sleep disorders and disease progression, potentially emerging as a biomarker for evaluating treatment outcomes.
Ethanol responsive lnc171 promotes migration and invasion of HCC cells via mir-873-5p/ZEB1 axis
Authors: Huang Shiping , Liao Zhouxiang , He Xiao , Song Zhenyu , Fang Xi , Wen Sha , Yang Lichao , Li Hui , Zhang Qi , Mo Wanling , Cheng Xiaojing , He Min , Huang Xuejing
Published: May 2024

Backgrounds

Long nonconding RNAs (lncRNAs) have been found to be a vital regulatory factor in the development process of human cancer, and could regarded as diagnostic or prognostic biomarkers for human cancers. Here, we aim to confirm the expression and molecular mechanism of RP11-171K16.5 (lnc171) in hepatocellular carcinoma (HCC).

Methods

Screening of differentially expressed lncRNAs by RNA sequencing. Expression level of gene was studied by quantitative real-time PCR (qRT-PCR). The effects of lnc171, mir-873-5p, and ethanol on migration and invasion activity of cells were studied used transwell assay, and luciferase reporter assay was used to confirm the binding site.

Results

RNA sequencing showed that lnc171 was markedly up-regulated in HCC. siRNA-mediated knockdown of lnc171 repressed the migration and invasion ability of HCC cells. Bioinformatic analysis, dual luciferase reporter assay, and qRT-PCR indicated that lnc171 interacted with mir-873-5p in HCC cells, and Zin-finger E-box binding homeobox (ZEB1) was a downstream target gene of mir-873-5p. In addition, lnc171 could enhance migration and invasion ability of HCC cells by up-regulating ZEB1 via sponging mir-873-5p. More interestingly, ethanol stimulation could up-regulate the increase of lnc171, thereby regulating the expression of competing endogenous RNA (ceRNA) network factors which lnc171 participated in HCC cells.

Conclusions

Our date demonstrates that lnc171 was a responsive factor of ethanol, and plays a vital role in development of HCC via binding of mir-873-5p.