bluuebunny/crossref_metadata_2025 huggingface dataset:
Renewal approach for the energy–momentum relation of the Fröhlich polaron
Authors: Polzer Steffen
Published: August 2023

We study the qualitative behaviour of the energy–momentum relation of the Fröhlich polaron at fixed coupling strength. Among other properties, we show that it is non-decreasing and that the correction to the quasi-particle energy is negative. We give a proof that the effective mass lies in $$(1, \infty )$$

(
1
,
∞
)

that does not need the validity of a central limit theorem for the path measure.
Transformative experience and the principle of informed consent in medicine
Authors: Egerton Karl , Capitelli-McMahon Helen
Published: August 2023

This paper explores how transformative experience generates decision-making problems of particular seriousness in medical settings. Potentially transformative experiences are especially likely to be encountered in medicine, and the associated decisions are confronted jointly by patients and clinicians in the context of an imbalance of power and expertise. However in such scenarios the principle of informed consent, which plays a central role in guiding clinicians, is unequal to the task. We detail how the principle’s assumptions about autonomy, rationality and information handle transformative experiences poorly, appealing to several difficult cases for medical decision-making to illustrate the resulting problem, and we consider how the existing literature on complications with consent fails to offer a resolution. We argue that recognition of the problem has a role to play in achieving a more effective response to transformative decisions. In Sect. 1 we introduce several representative cases of challenging patient decision-making that clinicians might face. In Sect. 2 we detail how transformative experience has been analysed in the recent literature, before outlining in Sect. 3 the theoretical basis of the principle of informed consent, which plays a central role in how clinicians are expected to support decision-making. In Sect. 4, having laid the groundwork for a clear description, we return to the cases given in Sect. 1 to confirm how their transformative nature presents a problem: either clinicians treat the decisions faced by these patients as ‘normal’, encouraging them to focus on information provision that patients may be unable to act on, or they treat them as transformative, in which case they lack the resources to recognise whether they are helping patients make (subjectively) good decisions. In Sect. 5 we argue that the existing literature does not offer any escape from this problem. We close in Sect. 6 by noting the significant impact that appreciating the problem of transformative experience could have on supporting transformative decisions in medicine and briefly suggesting how we might aim to develop new approaches to dealing with these.
A Second-Order Finite Volume Method for Field-Scale Reservoir Simulation
Authors: Kvashchuk Anna , Klöfkorn Robert , Sandve Tor Harald
Published: August 2023

Subsurface reservoirs are large complex systems. Reservoir flow models are defined on complex grids that follow geology with relatively large block sizes to make consistent simulations feasible. Reservoir engineers rely on established reservoir simulation software to model fluid flow. Nevertheless, fluid front position inaccuracies and front smearing on large grids may cause significant errors and make it hard to predict hydrocarbon production efficiency. We investigate higher-order methods that reduce these undesired effects without refining the grid, thus making reservoir simulation more accurate and robust. For this paper, we implemented a second-order finite volume method with linear programming (LP) reconstruction in the open-source industry-grade reservoir simulator OPM Flow (part of the open porous media initiative, OPM). We benchmark it against the first-order method on full-scale cases with standard coarse and refined grids. We prepared open refined-grid models of a synthetic reservoir with an unstructured grid and refined Norne field example. Our results confirm that the LP method predicts front positions as accurately as the first-order method on the refined grid for problems dominated by transport. These include the water alternating gas scenario on the synthetic reservoir and piston-type injection on the Norne field. Moreover, we study the gains from the LP method for CO$$_{2}$$

2

injection problems on the Norne field with full multi-phase complexity beyond transport. We observe the relevant difference between the first- and the second-order methods in these cases. However, in some configurations, the reservoir complexity overshadows the gains from the second-order methods.
The Right Spin: Learning Object Motion from Rotation-Compensated Flow Fields
Authors: Bideau Pia , Learned-Miller Erik , Schmid Cordelia , Alahari Karteek
Published: August 2023

A good understanding of geometrical concepts as well as a broad familiarity with objects lead to excellent human perception of moving objects. The human ability to detect and segment moving objects works in the presence of multiple objects, complex background geometry, motion of the observer and even camouflage. How we perceive moving objects so reliably is a longstanding research question in computer vision and borrows findings from related areas such as psychology, cognitive science and physics. One approach to the problem is to teach a deep network to model all of these effects. This is in contrast with the strategy used by human vision, where cognitive processes and body design are tightly coupled and each is responsible for certain aspects of correctly identifying moving objects. Similarly, from the computer vision perspective there is evidence that classical, geometry-based techniques are better suited to the “motion-based” parts of the problem, while deep networks are more suitable for modeling appearance. In this work, we argue that the coupling of camera rotation and camera translation can create complex motion fields that are difficult for a deep network to untangle directly. We present a novel probabilistic model to estimate the camera’s rotation given the motion field. We then rectify the flow field to obtain a rotation-compensated motion field for subsequent segmentation. This strategy of first estimating camera motion, and then allowing a network to learn the remaining parts of the problem, yields improved results on the widely used DAVIS benchmark as well as the more recent motion segmentation data set MoCA (Moving Camouflaged Animals).
Influence of Various Accessories Upstream Large Water Meters
Authors: Albaina Iñigo , Bidaguren Iñigo , Izquierdo Urko , Esteban G. A.
Published: August 2023

The focus of this study is on large flow meters, for which there is limited information due to their large size, making testing and research challenging. This research was conducted to quantify the effects of various accessories located upstream of these meters. Even a small percentage of variation in error can correspond to a significant volume of water. Accurate meters are crucial in many applications that involve large volumes of water as precise flow measurements are necessary for smooth and efficient processes while avoiding costly errors and downtime. Inaccurate large water meters can have far-reaching implications, such as overbilling or underbilling and production inefficiencies, which result in wasted resources and energy. Furthermore, inaccurate flow measurements can lead to environmental consequences as industries must comply with strict regulations regarding wastewater discharge limits. Uncertainty about the economic impact of an accessory installed upstream of a medium-sized water meter leads many water utilities to oversize the meter chambers to mitigate potential negative errors. In this study, six types of elements were tested upstream of ten brand-new water meters from six different manufacturers, constructed using four different metering technologies: single-jet, Woltmann, electromagnetic, and ultrasonic. Each meter unit was tested at five flow rates, ranging from the minimum to overload. The tests were conducted with accessories set in different orientations and distances upstream of the water meters under study. The research shows that the accessories used can cause significant deviations in measuring errors compared to the regular errors found under undisturbed working conditions.
Anoxygenic phototrophic purple non-sulfur bacteria: tool for bioremediation of hazardous environmental pollutants
Authors: Dhar Kartik , Venkateswarlu Kadiyala , Megharaj Mallavarapu
Published: August 2023

The extraordinary metabolic flexibility of anoxygenic phototrophic purple non-sulfur bacteria (PNSB) has been exploited in the development of various biotechnological applications, such as wastewater treatment, biohydrogen production, improvement of soil fertility and plant growth, and recovery of high-value compounds. These versatile microorganisms can also be employed for the efficient bioremediation of hazardous inorganic and organic pollutants from contaminated environments. Certain members of PNSB, especially strains of Rhodobacter sphaeroides and Rhodopseudomonas palustris, exhibit efficient remediation of several toxic and carcinogenic heavy metals and metalloids, such as arsenic, cadmium, chromium, and lead. PNSB are also known to utilize diverse biomass-derived lignocellulosic organic compounds and xenobiotics. Although biodegradation of some substituted aromatic compounds by PNSB has been established, available information on the involvement of PNSB in the biodegradation of toxic organic pollutants is limited. In this review, we present advancements in the field of PNSB-based bioremediation of heavy metals and organic pollutants. Furthermore, we highlight that the potential role of PNSB as a promising bioremediation tool remains largely unexplored. Thus, this review emphasizes the necessity of investing extensive research efforts in the development of PNSB-based bioremediation technology.
The different roles of innovation intermediaries to generate value
Authors: Noviaristanti Siska , Acur Nuran , Mendibil Kepa
Published: August 2023

The development of innovation management practices toward openness, societal
grand challenges and emerging technologies have changed the roles and supporting
activities of innovation intermediaries. Innovation intermediaries are considered to be
organizations that generate value to other institutions or societies within an innovation
system. Despite the growth of innovation intermediary research in recent years, there
is still a lack of clarity about the different roles that intermediaries can play and the way
in which they generate value to the other institutions, industry and/or society. This
paper reviews current research to identify contemporary roles of innovation
intermediaries and explore the mechanisms they use to generate value. Through the
use of bibliographic coupling the paper presents a robust analysis of the intellectual
streams and key concepts underpinning innovation intermediary research. The paper
makes a contribution to the ongoing debate by proposing a framework that explains the
different roles of innovation intermediaries (knowledge broker, knowledge transfer
enabler, orchestrator, and value generator) and the functions embedded within the
roles at different levels of analysis, i.e., firm, industry, and national. The paper
concludes by discussing the theoretical and practical implications of the framework and
details key areas for future research.
Machine learning with multimodal neuroimaging data to classify stages of Alzheimer’s disease: a systematic review and meta-analysis
Authors: Odusami Modupe , Maskeliūnas Rytis , Damaševičius Robertas , Misra Sanjay
Published: August 2023

In recent years, Alzheimer’s disease (AD) has been a serious threat to human health. Researchers and clinicians alike encounter a significant obstacle when trying to accurately identify and classify AD stages. Several studies have shown that multimodal neuroimaging input can assist in providing valuable insights into the structural and functional changes in the brain related to AD. Machine learning (ML) algorithms can accurately categorize AD phases by identifying patterns and linkages in multimodal neuroimaging data using powerful computational methods. This study aims to assess the contribution of ML methods to the accurate classification of the stages of AD using multimodal neuroimaging data. A systematic search is carried out in IEEE Xplore, Science Direct/Elsevier, ACM DigitalLibrary, and PubMed databases with forward snowballing performed on Google Scholar. The quantitative analysis used 47 studies. The explainable analysis was performed on the classification algorithm and fusion methods used in the selected studies. The pooled sensitivity and specificity, including diagnostic efficiency, were evaluated by conducting a meta-analysis based on a bivariate model with the hierarchical summary receiver operating characteristics (ROC) curve of multimodal neuroimaging data and ML methods in the classification of AD stages. Wilcoxon signed-rank test is further used to statistically compare the accuracy scores of the existing models. With a 95% confidence interval of 78.87–87.71%, the combined sensitivity for separating participants with mild cognitive impairment (MCI) from healthy control (NC) participants was 83.77%; for separating participants with AD from NC, it was 94.60% (90.76%, 96.89%); for separating participants with progressive MCI (pMCI) from stable MCI (sMCI), it was 80.41% (74.73%, 85.06%). With a 95% confidence interval (78.87%, 87.71%), the Pooled sensitivity for distinguishing mild cognitive impairment (MCI) from healthy control (NC) participants was 83.77%, with a 95% confidence interval (90.76%, 96.89%), the Pooled sensitivity for distinguishing AD from NC was 94.60%, likewise (MCI) from healthy control (NC) participants was 83.77% progressive MCI (pMCI) from stable MCI (sMCI) was 80.41% (74.73%, 85.06%), and early MCI (EMCI) from NC was 86.63% (82.43%, 89.95%). Pooled specificity for differentiating MCI from NC was 79.16% (70.97%, 87.71%), AD from NC was 93.49% (91.60%, 94.90%), pMCI from sMCI was 81.44% (76.32%, 85.66%), and EMCI from NC was 85.68% (81.62%, 88.96%). The Wilcoxon signed rank test showed a low P-value across all the classification tasks. Multimodal neuroimaging data with ML is a promising future in classifying the stages of AD but more research is required to increase the validity of its application in clinical practice.
Biocontrol efficacy of endophytic fungus, Acremonium sclerotigenum, against Meloidogyne incognita under in vitro and in vivo conditions
Authors: Yao Yurong , Huo Jianfei , Ben Haiyan , Gao Wei , Hao Yongjuan , Wang Wanli , Xu Jingyang
Published: August 2023

Biocontrol microorganisms are important tools for the control of root knot nematodes (Meloidogyne spp.). Endophytic fungi have shown great potential as biocontrol agents in such applications. We here isolated an endophytic fungus from tomato root galls infected with M. incognita and identified the isolate as Acremonium sclerotigenum based on morphology and the internal transcribed spacer sequence. The biocontrol potential of this fungus was evaluated both in vitro and in vivo. Specifically, in vitro analyses were conducted to determine the potential of A. sclerotigenum to increase Meloidogyne incognita juvenile (J2 stage) mortality and decrease M. incognita egg hatching rates. The results revealed that A. sclerotigenum culture filtrates caused high J2 mortality rates (up to 95.5%) and significantly inhibited egg hatching (by up to ~ 43%). Furthermore, eggs treated with the culture filtrate were disaggregated and could not develop into nematodes. An in vivo experiment showed that treatment of tomato plants with A. sclerotigenum suppressed root knot nematode populations and significantly reduced the galling index. Both A. sclerotigenum treatment and exposure to the nematicide abamectin had good control effects, with efficacy rates of 55.43% and 70.58%, respectively. In summary, the endophytic fungus A. sclerotigenum here showed excellent potential for biocontrol of M. incognita. Further studies should be conducted to identify the nematicidal compounds produced by this fungus and to establish the molecular mechanism of action associated with the observed biocontrol effects.
A Peak Set with a Maximal Hausdorff Dimension on Each Slice
Authors: Kot Piotr
Published: August 2023

We consider a bounded balanced strictly convex domain $$\Omega \subset {\mathbb {C}}^{d}$$

Ω
⊂

C

d

with $$C^{2}$$

C
2

boundary. Then there exists a peak set E with Hausdorff dimension equal to 1 on each slice. In particular E has maximal possible Hausdorff dimension equal to $$2d-1$$

2
d
-
1

.
Hypertension and Dyslipidemia: the Two Partners in Endothelium-Related Crime
Authors: Dąbrowska Edyta , Narkiewicz Krzysztof
Published: August 2023

Purpose of Review

The goal of this article is to characterize the endothelium’s role in the development of hypertension and dyslipidemia and to point out promising therapeutic directions.

Recent Findings

Dyslipidemia may facilitate the development of hypertension, whereas the collaboration of these two silent killers potentiates the risk of atherosclerosis. The common pathophysiological denominator for hypertension and dyslipidemia is endothelial cell dysfunction, which manifests as dysregulation of homeostasis, redox balance, vascular tone, inflammation, and thrombosis. Treatment focused on mediators acting in these processes might be groundbreaking. Metabolomic research on hypertension and dyslipidemia has revealed new therapeutic targets. State-of-the-art solutions integrating interview, clinical examination, innovative imaging, and omics profiles along with artificial intelligence have been already shown to improve patients’ risk stratification and treatment.

Pathomechanisms underlying hypertension and dyslipidemia take place in the endothelium. Novel approaches involving endothelial biomarkers and bioinformatics advances could open new perspectives in patient management.
Acute urticaria—what to do?
Authors: Treudler Regina , Zarnowski Julia , Wagner Nicola
Published: August 2023

Acute urticaria (AU) is the most common cause of wheal formation. By definition, it does not persist for more than 6 weeks. It can occur at any age and is more commonly seen in atopic diathesis. Acute spontaneous urticaria is distinguished from inducible forms. This review highlights the clinical presentation, differential diagnosis, possible triggers, and therapeutic strategies. In childhood as in adulthood, viral infections are very frequently associated with acute urticaria, whereas drugs and food are less frequently described as triggers. However, it is not uncommon for multiple triggers to be present simultaneously. Therapeutically, oral nonsedating H1 antihistamines are mainly used. In some patients, concomitant short-term administration of glucocorticosteroids is also necessary.
Trimming the Degrees of Freedom via a K+ Flux Rectifier for Safe and Long-Life Potassium-Ion Batteries
Authors: Yi Xianhui , Rao Apparao M. , Zhou Jiang , Lu Bingan
Published: August 2023

High degrees of freedom (DOF) for K+ movement in the electrolytes is desirable, because the resulting high ionic conductivity helps improve potassium-ion batteries, yet requiring support from highly free and flammable organic solvent molecules, seriously affecting battery safety. Here, we develop a K+ flux rectifier to trim K ion’s DOF to 1 and improve electrochemical properties. Although the ionic conductivity is compromised in the K+ flux rectifier, the overall electrochemical performance of PIBs was improved. An oxidation stability improvement from 4.0 to 5.9 V was realized, and the formation of dendrites and the dissolution of organic cathodes were inhibited. Consequently, the K||K cells continuously cycled over 3,700 h; K||Cu cells operated stably over 800 cycles with the Coulombic efficiency exceeding 99%; and K||graphite cells exhibited high-capacity retention over 74.7% after 1,500 cycles. Moreover, the 3,4,9,10-perylenetetracarboxylic diimide organic cathodes operated for more than 2,100 cycles and reached year-scale-cycling time. We fabricated a 2.18 Ah pouch cell with no significant capacity fading observed after 100 cycles.
Dual functions of a novel effector in the plant and pathogen arms race
Authors: Lu Han , Gao Mingjun
Published: August 2023

Ralstonia solanacearum is a soil-borne bacterium that causes bacterial wilt disease in over 250 plant species. It has been identified as one of the top ten most serious plant pathogenic bacteria globally, causing significant crop yield loss every year. Despite its large impact on agricultural economics, the molecular mechanisms underlying plant defense against Ralstonia infection and by which Ralstonia grows within the plant xylem remain largely unexplored. In a recent article, Ke et al. discovered a distinct pathogen effector, which acted as an immune elicitor in plants but also played dual roles in compromising plant immune activation and increasing nutrient acquisition from the host plants for pathogen propagation.
Grievance Formation, Rights and Remedies
Authors: Alaattinoğlu Daniela
Published: August 2023

In the last century, the treatment of victims of involuntary sterilisation and castration in Nordic countries has varied drastically from state-to-state, across time and victim groups. Considering why this is the case, Daniela Alaattinoğlu investigates how laws and practices of involuntary, surgical sterilisation and castration have been established, abolished and remedied in three Nordic states: Sweden, Norway and Finland. Employing a vast range of primary and secondary sources, Alaattinoğlu traces the national and international developments of the last 100 years. Developing the concept of grievance formation, the book explores why some states have claimed public responsibility while others have not, and why some victim groups have mobilised while others have remained silent. Through this pioneering analysis, Alaattinoğlu illuminates issues of human and constitutional rights, the evolution of the welfare state and state responsibility in both a national and global context.
Romeo and Juliet
Authors: Shakespeare William , Lees-Jeffries Hester
Published: August 2023

For this updated critical edition of Romeo and Juliet, Hester Lees-Jeffries has written a completely new introduction. It draws on recent research in theatre to set Romeo and Juliet in its mid-1590s context, making connections with other plays by Shakespeare and other literature of the period, as well as with the social and cultural contexts of the day, with discussions of London and Italy, dancing and duelling, marriage, gender and sexuality. It includes detailed discussion of the play in performance from the Restoration to the present day, with a particular focus on film (including global cinema), music and dance, and also explores other adaptations and afterlives, including young-adult fiction. The edition retains the commentary and Textual Analysis of the previous editor, G. Blakemore Evans; the Textual Analysis is prefaced with a short note contextualising its conclusions in the light of more recent research.
Accès à la justice et inclusion numérique : au-delà des enjeux technologiques
Authors: Prom Tep Sandrine , Millerand Florence , Parada Alexandra
Published: August 2023

Cet article s’intéresse aux inégalités numériques qui touchent l’accès aux services publics, et plus précisément à la justice. Au Québec, les plumitifs sont des registres publics qui retracent l’historique judiciaire des justiciables, et ils sont disponibles en ligne. Dans une perspective d’accès à la justice, cet article aborde la tension existante entre les objectifs de la numérisation des services publics et les inégalités d’accès au numérique, en s’intéressant au cas des plumitifs au Québec. Nous retraçons l’évolution des approches en termes d’inégalités numériques en insistant sur la nécessité de dépasser la question de l’accès matériel aux services numériques pour nous intéresser aussi aux inégalités socio-économiques préexistantes. Nous analysons les difficultés d’accès aux plumitifs et l’usage qui en sont fait à la lumière des différentes dimensions de l’accès numérique selon Jan van Dijk (2006) afin d’envisager des pistes de solutions concrètes et efficaces pour améliorer l’accès aux plumitifs et plus largement à la justice.
Barriers and facilitators to recruitment of underrepresented research participants: Perspectives of clinical research coordinators
Authors: Heffernan Marie E. , Barrera Leo , Guzman Zecilly R. , Golbeck Emily , Jedraszko Aneta M. , Hays P. Toddie , Herzog Keith A. , D’Aquila Richard T. , Ison Michael G. , McColley Susanna A.
Published: August 2023

Background:

Insufficient recruitment of groups underrepresented in medical research threatens the generalizability of research findings and compounds inequity in research and medicine. In the present study, we examined barriers and facilitators to recruitment of underrepresented research participants from the perspective of clinical research coordinators (CRCs).

Methods:

CRCs from one adult and one pediatric academic medical centers completed an online survey in April-May 2022. Survey topics included: participant language and translations, cultural competency training, incentives for research participation, study location, and participant research literacy. CRCs also reported their success in recruiting individuals from various backgrounds and completed an implicit bias measure.

Results:

Surveys were completed by 220 CRCs. CRCs indicated that recruitment is improved by having translated study materials, providing incentives to compensate participants, and reducing the number of in-person study visits. Most CRCs had completed some form of cultural competency training, but most also felt that the training either had no effect or made them feel less confident in approaching prospective participants from backgrounds different than their own. In general, CRCs reported having greater success in recruiting prospective participants from groups that are not underrepresented in research. Results of the implicit bias measure did not indicate that bias was associated with intentions to approach a prospective participant.

Conclusions:

CRCs identified several strategies to improve recruitment of underrepresented research participants, and CRC insights aligned with insights from research participants in previous work. Further research is needed to understand the impact of cultural competency training on recruitment of underrepresented research participants.
How does the antimicrobial stewardship provider role affect prospective audit and feedback acceptance for restricted antibiotics in a Canadian tertiary-care center?
Authors: Hammond Keely M. , Kabbani Dima , Doucette Karen E. , Smith Stephanie W. , Lau Cecilia , Bains Serena , Fong Karen , Stewart Jackson , Chen Justin Z.
Published: August 2023

Of 731 restricted antimicrobial prescriptions subject to antimicrobial stewardship program (ASP) prospective audit and feedback (PAF) over a 3-year period, 598 PAF recommendations (82%) were fully accepted. Physician auditors had an increased odds of PAF recommendation acceptance, reinforcing the complementary role of the ASP physician in the multidisciplinary ASP team.
A contractor comparison of novel IPT tools and techniques for Brazilian peppertree (Schinus terebinthifolia) management
Authors: Bell Mackenzie E. , Enloe Stephen F. , Leary James K. , Lauer Dwight K.
Published: August 2023

Brazilian peppertree (Schinus terebinthifolia Raddi) is a multistemmed shrub or small tree from South America that is invasive in Florida, Texas, Hawaii, and Australia. It forms multistemmed trunks with spreading branches that create dense thickets. State agencies in Florida manage it at annual costs of over $3 million, and individual plant treatment (IPT) techniques are widely used for control. Recent research testing novel hack and squirt approaches with aminopyralid and aminocyclopyrachlor and basal bark treatment with a new triclopyr formulation has shown these treatments are highly effective. However, they have not been evaluated at larger scales, which would be useful to land managers. Therefore, our objective was to compare the reduced hack and squirt technique using aminopyralid and aminocyclopyrachlor herbicides to basal bark treatment with triclopyr on a field scale. We used two contractor crews to apply treatments to twenty-four 0.2-ha plots. Treatments included aminocyclopyrachlor (120 g L−1) or aminopyralid (120 g L−1) applied with the reduced hack and squirt technique and triclopyr ester (108 g L−1) and triclopyr acid (34 g L−1) formulations applied with two basal bark treatment techniques. We confirmed that reduced hack and squirt significantly reduced the amount of herbicide and carrier applied compared with the basal bark treatments. By 540 d after treatment, aminocyclopyrachlor more effectively controlled S. terebinthifolia than aminopyralid with reduced hack and squirt and resulted in control comparable to that seen with either triclopyr basal bark treatment. These results verify reduced hack and squirt treatment with aminocyclopyrachlor and basal bark treatment with triclopyr acid as alternatives to basal bark treatment with triclopyr ester. Both resulted in significantly less herbicide use with comparable efficacy. This operational research approach has accelerated our understanding of novel IPT strategies and their implementation in the field.
Comparing input interfaces to elicit belief distributions
Authors: Crosetto Paolo , de Haan Thomas
Published: August 2023

This paper introduces a new software interface to elicit belief distributions of any shape: Click-and-Drag. The interface was tested against the state of the art in the experimental literature—a text-based interface and multiple sliders—and in the online forecasting industry—a distribution-manipulation interface similar to the one used by the most popular crowd-forecasting website. By means of a pre-registered experiment on Amazon Mechanical Turk, quantitative data on the accuracy of reported beliefs in a series of induced-value scenarios varying by granularity, shape, and time constraints, as well as subjective data on user experience were collected. Click-and-Drag outperformed all other interfaces by accuracy and speed, and was self-reported as being more intuitive and less frustrating, confirming the pre-registered hypothesis. Aside of the pre-registered results, Click-and-Drag generated the least drop-out rate from the task, and scored best in a sentiment analysis of an open-ended general question. Further, the interface was used to collect homegrown predictions on temperature in New York City in 2022 and 2042. Click-and-Drag elicited distributions were smoother with less idiosyncratic spikes. Free and open source, ready to use oTree, Qualtrics and Limesurvey plugins for Click-and-Drag, and all other tested interfaces are available at https://beliefelicitation.github.io/.
The Use of Energy History
Authors: Wellum Caleb
Published: August 2023

While there is no energy determinism, there is a powerful energy determination at work in all societies.
COMPARING BIOAPATITE AND COLLAGEN RADIOCARBON DATES FROM A 16TH CENTURY CEMETERY CONTEXT—EL JAPÓN, XOCHIMILCO, MEXICO CITY
Authors: Alarcón Tinajero Edgar , Hadden Carla S , Cherkinsky Alexander
Published: August 2023

El Japón is a 16th century hamlet site in the marshlands of the southern Basin of Mexico in central Mesoamerica. Radiocarbon (14C) dating and OxCal modeling of human bone collagen (n = 11) identifies a range of burials at El Japón cemetery from 1550–1650 cal. CE. The refined chronology identifies use of this rural settlement well after the onset of colonial government-sponsored relocation of Indigenous people to larger settlements (congregaciones). Historically documented information in this work supports chronological modeling beyond stand-alone calibration. Stable isotopic study of bone samples demonstrates similar sources of dietary protein and carbohydrates. The similarity of carbon sources for bone apatite (bioapatite) and collagen offers security that both bone fractions are viable 14C dating opportunities. Recent extension of this work examines bioapatite 14C dates (n = 5) from the same bone samples when quality parameters are met—atomic carbon-nitrogen ratios of 3.2–3.3 and collagen yield of 10–20%. No significant difference is found between collagen and bioapatite dates of the same individuals (p = 0.17, Mann-Whitney U test). 14C dates from human bone samples in this primarily terrestrial dietary context can be successfully acquired from either collagen or bioapatite fractions.
Why ‘Reception History’ Is Not Just Another Exegetical Method: The Case Of Mark's Ending
Authors: Burnet Régis
Published: August 2023

The history of reception is suffering from a fundamental misunderstanding. Since the publication of Truth and Method, everyone has had the impression that reception history is just another exegetical technique. However, the heart of Gadamer's argument is not the history of the effects of the text, but the historicity of understanding: a text is seized only within the limits of the historical situation of its interpreter. To demonstrate this point, this paper takes the example of the Markan ending. Surprisingly, a 16th-century Thomistic theologian, Cajetan, and a contemporary commentary are so close that one might think they are defending the same view of the text. Both intend to maintain the canonicity of verses 9–20, but both point out that it may be adventurous to build any doctrine or practice on these verses alone. But the context is different, obviously. The first one tries to justify a conception of faith that does not depend directly on miracles; the second one affirms a hermeneutic centred on the interpreter's response, being wary of its ecclesiological drifts. This confirms that theological considerations rather than philological ones have prevailed in challenging Mark's ending.
Rezeptionskritik und Rezeptionsgeschichte des Neuen Testaments: Eine methodologische Skizze
Authors: Hoegen-Rohls Christina
Published: August 2023

German Abstract

Angesichts der fortschreitenden Publikation der Encyclopedia of the Bible and Its Reception (EBR), der Weiterarbeit an den Bänden des Evangelisch-Katholischen Kommentars zum Neuen Testament (EKK) und der Fortsetzung von Blackwell's Kommentarserie Through the Centuries lautet die Leitfrage des vorliegenden Artikels: Wie kann zur Theoretisierung und Methodisierung einer Rezeptionsgeschichte des Neuen Testaments beigetragen werden? Um diese Frage zu beantworten und Perspektiven zu entwerfen, unternimmt der Artikel den Versuch einer neuerlichen Klärung der Begriffe ‘Wirkungsgeschichte’ / ‘wirkungsgeschichtliches Bewusstsein’, ‘Auslegungsgeschichte’, ‘Rezeptionsgeschichte’ und schlägt zwei Fragenkataloge vor, die das Vorgehen einer cross-temporal und cross-cultural ausgerichteten Rezeptionskritik des Neuen Testaments inhaltlich und methodisch reflektieren und kontrollieren.
Paradox Postponed
Authors: Delaney Erin F.
Published: August 2023

A review of Stuart Ward's Untied Kingdom
Widowhood and functional impairment: gender-specific trajectories of sensory and masticatory functions
Authors: Song Kyungeun , Kim Jinho
Published: August 2023

Despite a large body of research on the effects of widowhood on health, little is known about whether spousal loss is related to functional impairment in widowed persons. This study examines the trajectories of functional impairment (sensory and masticatory functions) before and after spousal loss. This study also investigates whether the temporal changes in functional impairment of widowed people are gendered. Using data from the Korean Longitudinal Study of Ageing over seven waves (42,967 person-observations), this study estimated fixed effects regression models to account for unobserved individual-level heterogeneity. Gender-stratified fixed effects regression models were used to determine whether changes in functional impairment associated with spousal loss differ by gender. The results of this study indicated that the vision of widowed people began to decrease within the first year following spousal loss and persisted through the fourth and subsequent years. By contrast, mastication deterioration occurred only among widowers. Masticatory impairment began during the first year of spousal loss and lasted the entire survey period. No statistically significant reduction in hearing loss was found for both widowers and widows. The results of this study suggest that spousal loss has a long-term effect on functional impairment, particularly in vision and masticatory functions. This study also documents gender heterogeneity in the trajectories of functional impairment before and after spousal loss. Vision impairment was found to be universal among widowers and widows, whereas masticatory impairment was significant only among widows. To address the physical and psychological vulnerability of widowed people, policies should be developed early in the process of adjusting to widowhood.
Kinematic modeling and motion control of a parallel robotic antenna pedestal
Authors: He Shuai , Duan Xuechao , Qu Xianpu , Xiao Jiaxuan
Published: August 2023

This paper deals with kinematic modeling and motion control of a novel antenna pedestal based on parallel robotic mechanism. Its active joints are two sliders equipped with DC motors on a circular rail. The synchronous and asynchronous motions of the two sliders enable the antenna to rotate in azimuth and pitch. In order to solve the problem of trajectory deviation caused by nonlinear friction and other uncertain disturbances, the structure of the antenna is described at the beginning, and then, the kinematic model is established based on geometry method. Then, the fuzzy PI (FPI) control system is designed based on the position feedback of the driving slider to realize the trajectory tracking of the desired curve. Finally, the parameters of the FPI controller are optimized and validated by Simulink simulation experiments. The tracking performance and the effectiveness of the control algorithm on prototype are verified by experiments of typical trajectory following control.
Live Coding the Global Hyperorgan: The Paragraph environment in the indeterminate place
Authors: Petersson Mattias
Published: August 2023

This article presents several scenarios in which a live coding environment called Paragraph was utilised to telematically play networked and geographically distributed hyperorgans. Situated within the framework of theGlobal Hyperorganproject, the TCP/Indeterminate Place Quartet have explored the affordances of the organ network through the concept of Tele-Copresence. By outsourcing certain dimensions of the parameter space of the Paragraph language to other members of the quartet, a shared instrumentality is enabled, where the organs are collaboratively controlled by means of this system. Rooted in a personal composer-performer practice and studied from the perspective of the live coder, the Paragraph system, adapted to the TCP/Indeterminate Place environment, can be understood as a modular system of human and non-human agents, into which the other musicians are patched. The distributed parameter space utilised, thus resembles a sharedcantus firmus, a foundational, but dynamically changing, ecology for the live coder to play within.
A new approach to a powered knee prosthesis: Layering powered assistance onto strictly passive prosthesis behavior
Authors: Culver Steve C. , Vailati Léo G. , Morgenroth David C. , Goldfarb Michael
Published: August 2023

This article describes a novel approach to the control of a powered knee prosthesis where the control system provides passive behavior for most activities and then provides powered assistance only for those activities that require them. The control approach presented here is based on the categorization of knee joint function during activities into four behaviors: resistive stance behavior, active stance behavior, ballistic swing, and non-ballistic swing. The approach is further premised on the assumption that healthy non-perturbed swing-phase is characterized by a ballistic swing motion, and therefore, a replacement of that function should be similarly ballistic. The control system utilizes a six-state finite-state machine, where each state provides different constitutive behaviors (concomitant with the four aforementioned knee behaviors) which are appropriate for a range of activities. Transitions between states and torque control within states is controlled by user motion, such that the control system provides, to the extent possible, knee torque behavior as a reaction to user motion, including for powered behaviors. The control system is demonstrated on a novel device that provides a sufficiently low impedance to enable a strictly passive ballistic swing-phase, while also providing sufficiently high torque to offer powered stance-phase knee-extension during activities such as step-over stair ascent. Experiments employing the knee and control system on an individual with transfemoral amputation are presented that compare the functionality of the power-supplemented nominally passive system with that of a conventional passive microprocessor-controlled knee prosthesis.
Hedgehog signaling in tissue homeostasis, cancers and targeted therapies
Authors: Jing Junjun , Wu Zhuoxuan , Wang Jiahe , Luo Guowen , Lin Hengyi , Fan Yi , Zhou Chenchen
Published: August 2023

The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development and tissue homeostasis. It plays a central role in the regulation of the proliferation and differentiation of adult stem cells. Importantly, it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor prognosis and even increased mortality. Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer. A variety of drugs have been developed, including small molecule inhibitors, natural compounds, and long non-coding RNA (LncRNA), some of which are approved for clinical use. This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer. Furthermore, we address status quo and limitations of targeted therapies of HH signaling pathway. Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer, as well as opportunities and challenges of therapeutic targets for cancer.
Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer
Authors: Park Soon Young , Jeong Kang Jin , Poire Alfonso , Zhang Dong , Tsang Yiu Huen , Blucher Aurora S. , Mills Gordon B.
Published: August 2023

Ferroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). We found that GPX4, but not the xCT transporter, is selectively elevated in luminal breast cancer. Consistent with this observation, the majority of luminal breast cancer cell lines are exquisitely sensitive to RSL3 with limited sensitivity to erastin. In RSL3-resistant, but not sensitive, luminal breast cancer cell lines, RSL3 induces HER2 pathway activation. Irreversible HER2 inhibitors including neratinib reversed RSL3 resistance in constitutively RSL3-resistant cell lines. Combination treatment with RSL3 and neratinib increases ferroptosis through mitochondrial iron-dependent reactive oxygen species production and lipid peroxidation. RSL3 also activated replication stress and concomitant S phase and G2/M blockade leading to sensitivity to targeting the DNA damage checkpoint. Together, our data support the exploration of RSL3 combined with irreversible HER2 inhibitors in clinical trials.
LINC02015 modulates the cell proliferation and apoptosis of aortic vascular smooth muscle cells by transcriptional regulation and protein interaction network
Authors: Liu Fangyu , Wang Yulin , Huang Xitong , Liu Dingqian , Ding Wenjun , Lai Hao , Wang Chunsheng , Ji Qiang
Published: August 2023

Long intergenic nonprotein coding RNA 2015 (LINC02015) is a long non-coding RNA that has been found elevated in various cell proliferation-related diseases. However, the functions and interactive mechanism of LINC02015 remain unknown. This study aimed to explore the role of LINC02015 in the cell proliferation and apoptosis of vascular smooth muscle cells (VSMCs) to explain the pathogenesis of aortic diseases. Ascending aorta samples and angiotensin-II (AT-II) treated primary human aortic VSMCs (HAVSMCs) were used to evaluate the LINC02015 expression. RNA sequencing, chromatin isolation by RNA purification sequencing, RNA pull-down, and mass spectrometry (MS) were applied to explore the potential interacting mechanisms. LINC02015 expression was found elevated in aortic dissection and AT-II-treated HAVSMCs. Cell proliferation and cell cycle were activated in HAVSMCs with LINC02015 knockdown. The cyclins family and caspase family were found to participate in regulating the cell cycle and apoptosis via the NF-κB signaling pathway. RXRA was discovered as a possible hub gene for LINC02015 transcriptional regulating networks. Besides, the protein interaction network of LINC02015 was revealed with candidate regulating molecules. It was concluded that the knockdown of LINC02015 could promote cell proliferation and inhibit the apoptosis of HAVSMCs through an RXRA-related transcriptional regulation network, which could provide a potential therapeutic target for aortic diseases.
iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays
Authors: Fay Meredith E. , Oshinowo Oluwamayokun , Iffrig Elizabeth , Fibben Kirby S. , Caruso Christina , Hansen Scott , Musick Jamie O. , Valdez José M. , Azer Sally S. , Mannino Robert G. , Choi Hyoann , Zhang Dan Y. , Williams Evelyn K. , Evans Erica N. , Kanne Celeste K. , Kemp Melissa L. , Sheehan Vivien A. , Carden Marcus A. , Bennett Carolyn M. , Wood David K. , Lam Wilbur A.
Published: August 2023

While microscopy-based cellular assays, including microfluidics, have significantly advanced over the last several decades, there has not been concurrent development of widely-accessible techniques to analyze time-dependent microscopy data incorporating phenomena such as fluid flow and dynamic cell adhesion. As such, experimentalists typically rely on error-prone and time-consuming manual analysis, resulting in lost resolution and missed opportunities for innovative metrics. We present a user-adaptable toolkit packaged into the open-source, standalone Interactive Cellular assay Labeled Observation and Tracking Software (iCLOTS). We benchmark cell adhesion, single-cell tracking, velocity profile, and multiscale microfluidic-centric applications with blood samples, the prototypical biofluid specimen. Moreover, machine learning algorithms characterize previously imperceptible data groupings from numerical outputs. Free to download/use, iCLOTS addresses a need for a field stymied by a lack of analytical tools for innovative, physiologically-relevant assays of any design, democratizing use of well-validated algorithms for all end-user biomedical researchers who would benefit from advanced computational methods.