bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Ontology for Knowledge of Traditions Common Culture of Countries in the Greater Mekong Subregion
Authors: Hoaihongthong Suwannee , Kwiecien Kanyarat
Published: August 2022

The development of ontology is one important research area in the digital humanities. This study aims at creating a semantic search system for traditions common culture in the Greater Mekong Subregion (GMS) to solve problems in semantic gaps. This paper presents the second phase of the main research. It will present how to develop ontologies for the traditions and common culture in the GMS to gain a perspicuous understanding of the traditions and common culture of those countries in the region. A theoretical concept of seven steps for ontology development was applied by using an ontology editor called Hozo Ontology Editor. The main ontology found in this study included 15 main classes: common culture, history, belief, purpose, location, ritual, activity, literature, values, place, time, principle, person, equipment, and ethnic group. Traditions common culture is a subclass of common culture classes that were found to be related to all classes in ontology. This ontology will be useful for developing a semantic search system of the traditions common culture of the GMS in the next steps of the main study.
GIS-Based Spatial Analysis of Accident Hotspots: A Nigerian Case Study
Authors: Afolayan Abayomi , Easa Said M. , Abiola Oladapo S. , Alayaki Funmilayo M. , Folorunso Olusegun
Published: August 2022

This study identified high-risk locations (hotspots) using geographic information systems (GIS) and spatial analysis. Five years of accident data (2013–2017) for the Lokoja-Abuja-Kaduna highway in Nigeria were used. The accident concentration analysis was conducted using the mean center analysis and Kernel density estimation method. These locations were further verified using Moran’s I statistics (spatial autocorrelation) to determine their clustering with statistical significance. Fishnet polygon and network spatial weight matrix approaches of the Getis–Ord Gi* statistic were used in the hotspot analysis. Hotspots exist for 2013, 2014, and 2017 with a significance level between 95–99%. However, hotspots for 2015 and 2016 have a low significance level and the pattern is random. The spatial autocorrelation analysis of the overall accident locations and the Moran’s I statistic showed that the distribution of the accidents on the study route is random. Thus, preventive measures for hotspot locations should be based on a yearly hotspot analysis. The average daily traffic values of 31,270 and 16,303 were obtained for the northbound and southbound directions of the Abaji–Abuja section. The results show that hotspot locations with high confidence levels are at points where there are geometric features.
Cardiovascular Mortality Risk in Patients with Bladder Cancer: A Population-Based Study
Authors: Wang Shunde , Ge Chengguo , Zhang Junyong
Published: August 2022

Background: The purpose of this study was to evaluate the risk of cardiovascular mortality (CVM) among patients with bladder cancer (BC). Methods and Materials: Data were collected from the Surveillance, Epidemiology, and End Results (SEER) database for patients who were diagnosed with BC by pathology between 2000 and 2016. The standardized mortality rate (SMR) was calculated based on reference data from the general population. Nelson–Aalen cumulative hazard curves were used to assess the risk of experiencing CVM in BC patients. Multivariate competing risk models were performed. Results: In total, data from 237,563 BC patients were obtained from the SEER database for further analysis, of which 21,822 patients experienced CVM; the overall SMR for CVM in BC patients was 1.16 (95% CI: 1.14–1.17). Age, race, sex, year of diagnosis, histologic type, summary stage, surgery, marital status, and college education level were independent predictors of CVM in patients with BC. Conclusions: Patients with BC have a significantly increased risk of experiencing CVM compared to the general population. Pre-identification of high-risk groups and cardiovascular protection interventions are important measures to effectively improve survival in this group of patients.
The Impact of Cardiac Devices on Patients’ Quality of Life—A Systematic Review and Meta-Analysis
Authors: Willy Kevin , Ellermann Christian , Reinke Florian , Rath Benjamin , Wolfes Julian , Eckardt Lars , Doldi Florian , Wegner Felix K. , Köbe Julia , Morina Nexhmedin
Published: August 2022

The implantation of cardiac devices significantly reduces morbidity and mortality in patients with cardiac arrhythmias. Arrhythmias as well as therapy delivered by the device may impact quality of life of patients concerned considerably. Therefore we aimed at conducting a systematic search and meta-analysis of trials examining the impact of the implantation of cardiac devices, namely implantable cardioverter-defibrillators (ICD), pacemakers and left-ventricular assist devices (LVAD) on quality of life. After pre-registering the trial with the PROSPERO database, we searched Medline, PsycINFO, Web of Science and the Cochrane databases for relevant publications. Study quality was assessed by two independent reviewers using standardized protocols. A total of 37 trials met our inclusion criteria. Of these, 31 trials were cohort trials while 6 trials used a randomized controlled design. We found large pre-post effect sizes for positive associations between quality of life and all types of devices. The effect sizes for LVAD, pacemaker and ICD patients were g = 1.64, g = 1.32 and g = 0.64, respectively. There was a lack of trials examining the effect of implantation on quality of life relative to control conditions. Trials assessing quality of life in patients with cardiac devices are still scarce. Yet, the existing data suggest beneficial effects of cardiac devices on quality of life. We recommend that clinical trials on cardiac devices routinely assess quality of life or other parameters of psychological well-being as a decisive study endpoint. Furthermore, improvements in psychological well-being should influence decisions about implantations of cardiac devices and be part of patient education and may impact shared decision-making.
Recent Update on PCSK9 and Platelet Activation Experimental Research Methods: In Vitro and In Vivo Studies
Authors: Puteri Meidi Utami , Azmi Nuriza Ulul , Ridwan Salbiah , Iqbal Muhammad , Fatimah Tresni , Rini Tri Diana Puspita , Kato Mitsuyasu , Saputri Fadlina Chany
Published: August 2022

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial factor in the development and progression of cardiovascular diseases. PCSK9 has been demonstrated to modify LDL plasma levels and increase platelet activation, which promotes atherosclerosis, a defining feature of nearly all cardiovascular diseases. Platelet activation has been shown to promote and maintain the response to atherosclerosis development, from beginning to progression and exacerbation, which can lead to advanced cardiovascular events including myocardial infarction (MI) or death. Research on PCSK9 and platelet activation is currently underway with the main goal of reducing the risk of advanced cardiovascular events by preventing or slowing down atherosclerosis progression. Both in vitro and in vivo studies have been used to explore PCSK9 functions to develop new drugs targeting PCSK9. Finding the most suitable study models that represent the pathological and physiological systems found in humans is very important to achieving the goal. This review aimed to present a current and comprehensive overview of the experimental models that have been used to investigate the role of PCSK9 in platelet activation-induced atherosclerotic cardiovascular diseases.
Atopic Dermatitis: Striving for Reliable Biomarkers
Authors: Mastraftsi Styliani , Vrioni Georgia , Bakakis Michail , Nicolaidou Electra , Rigopoulos Dimitrios , Stratigos Alexander , Gregoriou Stamatios
Published: August 2022

Atopic dermatitis (AD) is a highly heterogeneous inflammatory disease regarding both its pathophysiology and clinical manifestations. However, it is treated according to the “one-size-fits-all” approach, which may restrict response to treatment. Thus, there is an unmet need for the stratification of patients with AD into distinct endotypes and clinical phenotypes based on biomarkers that will contribute to the development of precision medicine in AD. The development of reliable biomarkers that may distinguish which patients with AD are most likely to benefit from specific targeted therapies is a complex procedure and to date none of the identified candidate biomarkers for AD has been validated for use in routine clinical practice. Reliable biomarkers in AD are expected to improve diagnosis, evaluate disease severity, predict the course of disease, the development of comorbidities, or the therapeutic response, resulting in effective and personalized treatment of AD. Among the studied AD potential biomarkers, thymus and activation-regulated chemokine/C-C motif ligand 17 (TARC/CCL17) has the greatest evidence-based support for becoming a reliable biomarker in AD correlated with disease severity in both children and adults. In this review, we present the most prominent candidate biomarkers in AD and their suggested use.
Drug-Associated Parosmia: New Perspectives from the WHO Safety Database
Authors: Merino Diane , Gérard Alexandre Olivier , Thümmler Susanne , Ben Othman Nouha , Viard Delphine , Rocher Fanny , Destere Alexandre , Van Obberghen Elise Katheryne , Drici Milou-Daniel
Published: August 2022

Parosmia is a qualitative distortion of smell perception. Resulting from central causes, sinonasal diseases, and infections, parosmia has also been associated with medications. Therefore, we aimed to investigate potential signals for drugs associated with parosmia. VigiBase® (the WHO pharmacovigilance database) was queried for all reports of “Parosmia” (MedDRA Preferred Term), registered up to 23 January 2022. Disproportionality analysis relied on the reporting odds ratio and the information component. A signal is detected when the lower end of the 95% confidence interval of the information component is positive. We found 14,032 reports of parosmia, with a median patient age of 53 years. Most reported drugs were antiinfectives, among which COVID-19 vaccines accounted for 27.1% of reports. Antibiotics and corticosteroids were involved in 6.8% and 4.6% of reports. Significant disproportionate reporting was detected for corticosteroids, antibiotics, drugs used in nicotine dependence, COVID-19 and HPV vaccines, serotonin–norepinephrine reuptake inhibitors (SNRI), and incretin mimetics. We suggest potential safety signals involving nicotine replacement therapies and vaccines. We also highlight the potential role of less suspected classes, such as SNRIs and incretin mimetics. An iatrogenic etiology should be evoked when parosmia occurs, especially in the elderly.
Pancreatic Incidentaloma
Authors: Caban Miłosz , Małecka-Wojciesko Ewa
Published: August 2022

Pancreatic incidentalomas (PIs) represent a clinical entity increasingly recognized due to advances in and easier access to imaging techniques. By definition, PIs should be detected during abdominal imaging performed for indications other than a pancreatic disease. They range from small cysts to invasive cancer. The incidental diagnosis of pancreatic cancer can contribute to early diagnosis and treatment. On the other hand, inadequate management of PIs may result in overtreatment and unneeded morbidity. Therefore, there is a strong need to evaluate the nature and clinical features of individual PIs. In this review, we summarize the major characteristics related to PIs and present suggestions for their management.
Recent Advances in Understanding of Cardiovascular Diseases in Patients with Chronic Kidney Disease
Authors: Krisanapan Pajaree , Pattharanitima Pattharawin , Thongprayoon Charat , Cheungpasitporn Wisit
Published: August 2022

Chronic kidney disease (CKD) is a major public health problem, affecting between 8% and 16% of the population worldwide [...]
Small Aperture IC-8 Extended-Depth-of-Focus Intraocular Lens in Cataract Surgery: A Systematic Review
Authors: Sánchez-González José-María , Sánchez-González María Carmen , De-Hita-Cantalejo Concepción , Ballesteros-Sánchez Antonio
Published: August 2022

The aim of this paper is to evaluate the visual outcomes and patient satisfaction of small aperture IC-8 IOLs in cataract patients with or without prior ocular events. A systematic review of full-length original English studies reporting the visual results of small aperture IC-8 IOL implantation after cataract surgery in three databases, PubMed, Web of Science and Scopus, was performed according to the PRISMA statement. The Quality Assessment Tool for case series studies from the National Heart, Lung, and Blood Institute was used to analyze the quality of the studies selected. The search provided 543 articles, of which 22 were included in this systematic review. Significant improvements in uncorrected distance visual acuity (UDVA); uncorrected intermediate visual acuity (UIVA); uncorrected near visual acuity (UNVA); perception of photic phenomena; and patient satisfaction have been reported. Unilateral and bilateral small aperture IC-8 IOL implantation reduces photic phenomena and provides good vision for all distances with high patient satisfaction and minimal postoperative complications. Therefore, the implantation of this IOL may be recommended for patients with cataracts, corneal irregularities and ocular trauma with partial aniridia.
Epilepsy in Pediatric Patients—Evaluation of Brain Structures’ Volume Using VolBrain Software
Authors: Woźniak Magdalena Maria , Zbroja Monika , Matuszek Małgorzata , Pustelniak Olga , Cyranka Weronika , Drelich Katarzyna , Kopyto Ewa , Materniak Andrzej , Słomka Tomasz , Cebula Maciej , Brodzisz Agnieszka
Published: August 2022

Epilepsy is one of the most frequent serious brain disorders. Approximately 30,000 of the 150,000 children and adolescents who experience unprovoked seizures are diagnosed with epilepsy each year. Magnetic resonance imaging is the method of choice in diagnosing and monitoring patients with this condition. However, one very effective tool using MR images is volBrain software, which automatically generates information about the volume of brain structures. A total of 57 consecutive patients (study group) suffering from epilepsy and 34 healthy patients (control group) who underwent MR examination qualified for the study. Images were then evaluated by volBrain. Results showed atrophy of the brain and particular structures—GM, cerebrum, cerebellum, brainstem, putamen, thalamus, hippocampus and nucleus accumbens volume. Moreover, the statistically significant difference in the volume between the study and the control group was found for brain, lateral ventricle and putamen. A volumetric analysis of the CNS in children with epilepsy confirms a decrease in the volume of brain tissue. A volumetric assessment of brain structures based on MR data has the potential to be a useful diagnostic tool in children with epilepsy and can be implemented in clinical work; however, further studies are necessary to enhance the effectiveness of this software.
Glycemic Control after Initiation of Anti-VEGF Treatment for Diabetic Macular Edema
Authors: Oshima Hideyuki , Takamura Yoshihiro , Hirano Takao , Shimura Masahiko , Sugimoto Masahiko , Kida Teruyo , Matsumura Takehiro , Gozawa Makoto , Yamada Yutaka , Morioka Masakazu , Inatani Masaru
Published: August 2022

Diabetic macular edema (DME) induces visual disturbance, and intravitreal injections of anti-vascular endothelial growth factor (VEGF) drugs are the accepted first-line treatment. We investigate its impact on glycemic control after starting VEGF treatment for DME on the basis of a questionnaire and changes in hemoglobin A1c (HbA1c). We conducted a retrospective multicenter study analyzing 112 patients with DME who underwent anti-VEGF therapy and their changes in HbA1c over two years. Central retinal thickness and visual acuity significantly improved at three months and throughout the period after initiating therapy (p < 0.0001); a significant change in HbA1c was not found. A total of 59.8% of patients became more active in glycemic control through exercise and diet therapy after initiating therapy, resulting in a significantly lower HbA1c at 6 (p = 0.0047), 12 (p = 0.0003), and 18 (p = 0.0117) months compared to patients who did not. HbA1c was significantly lower after 18 months in patients who stated that anti-VEGF drugs were expensive (p = 0.0354). The initiation of anti-VEGF therapy for DME affects HbA1c levels in relation to more aggressive glycemic control.
FCER1G Gene Hypomethylation in Patients with Rheumatoid Arthritis
Authors: Podgórska Dominika , Cieśla Marek , Kolarz Bogdan
Published: August 2022

Rheumatoid arthritis (RA) is a chronic autoimmune disease that, when improperly treated, leads to disability in patients. Various factors that may cause the development and activity of RA are being considered. Epigenetic factors are also receiving increasing attention. In our study, we analyzed the association between FCER1G gene methylation and RA activity. We conducted our study in 50 RA patients and 24 controls. The patients were divided into two groups in terms of high disease activity and remission. Quantitative real-time methylation-specific PCR was used to analyze the methylation status of the investigated genes. We observed that RA patients have lower levels of methylation of the FCER1G gene compared to controls, but we did not find any difference in the methylation status of this gene between patients with high disease activity and remission. The results of this study suggest that FCER1G gene methylation may be a new potential epigenetic marker of RA that is independent of disease activity.
Non-Invasive Evaluation of Intradiscal Deformation during Axial Loading of the Spine Using Deformation-Field Magnetic Resonance Imaging: A Potential Tool for Micro-Instability Measurements
Authors: Johansson Frida , Sirat Zainab , Hebelka Hanna , Brisby Helena , Nordström Fredrik , Lagerstrand Kerstin
Published: August 2022

Degeneration alters the structural components of the disc and its mechanical behavior. Understanding this pathophysiological process is of great importance, as it may lead to back pain. However, non-invasive methods to characterize the disc mechanics in vivo are lacking. Here, a potential method for measurements of the intradiscal deformation under stress is presented. The method utilizes a standard MRI protocol, commercial loading equipment, and registration software. The lumbar spine (L1/L2–L5/S1) of 36 human subjects was imaged with and without axial loading of the spine. The resulting images were registered, and changes in the images during the registration were displayed pixel-by-pixel to visualize the internal deformation of the disc. The degeneration grade, disc height, disc angle and tilt angle were determined and correlated with the deformation using multivariate regression analysis. The largest deformation was found at the lower lumbar spine, and differences in regional behaviors between individual discs were found. Weak to moderate correlations between the deformation and different disc characteristics were found, where the degeneration grade and tilt angle were the main contributing factors. To conclude, the image-based method offers a potential tool to study the pathophysiological process of the disc.
Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
Authors: Wirkner Janine , Scheuch Matthias , Dabers Thomas , Freiin von Rheinbaben Sabrina , Fiene Beate , Aymanns Simone , Endlich Karlhans , Endlich Nicole , Lendeckel Uwe , Rettig Rainer , Grabe Hans Jörgen , Stracke Sylvia
Published: August 2022

Given the increasing prevalence of chronic kidney disease (CKD) and its impact on health care, it is important to better understand the multiple factors influencing health-related quality of life (HRQOL), particularly since they have been shown to affect CKD outcomes. Determinants of HRQOL as measured by the validated Kidney Disease Quality of Life questionnaire (KDQOL) and the Patient Health Questionnaire depression screener (PHQ-9) were assessed in a routine CKD patient sample, the Greifswald Approach to Individualized Medicine (GANI_MED) renal cohort (N = 160), including a wide range of self-reported data, sociodemographic and laboratory measures. Compared to the general population, CKD patients had lower HRQOL indices. Dialysis was associated with (1) low levels of physical functioning, (2) increased impairments by symptoms and problems, and (3) more effects and burden of kidney disease. HRQOL is seriously affected in CKD patients. However, impairments were found irrespective of eGFR decline and albuminuria. Rather, the comorbid conditions of depression and diabetes predicted a lower HRQOL (physical component score). Further studies should address whether recognizing and treating depression may not only improve HRQOL but also promote survival and lower hospitalization rates of CKD patients.
Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis
Authors: Hussain Salman , Singh Ambrish , Antony Benny , Klugarová Jitka , Murad M. Hassan , Jayraj Aarthi S. , Langaufová Alena , Klugar Miloslav
Published: August 2022

Evidence from preclinical studies suggests a preventive effect of proton pump inhibitors (PPIs) in preeclampsia. Recently, several epidemiological studies have described a conflicting association between the use of PPIs during pregnancy and preeclampsia risk. This study aimed to evaluate the association between PPI use and the risk of preeclampsia. We searched databases, including MEDLINE, Embase, Scopus, Web of Science Core Collection, Emcare, CINAHL, and the relevant grey literature from inception until 13 September 2021. Studies reporting the preeclampsia risk with the use of PPIs were eligible for inclusion. Literature screening, data extraction, and the risk of bias assessment were performed independently by two investigators. Random-effect meta-analysis was performed to generate relative risks (RR) and 95% confidence intervals (CI). The risk of preeclampsia and preterm preeclampsia among women receiving PPIs during pregnancy were the primary outcomes of interest. This meta-analysis comprised three studies involving 4,877,565 pregnant women, of whom 119,017 were PPI users. The included studies were judged to have a low risk of bias. The risk of preeclampsia among pregnant women who received PPIs anytime during pregnancy was significantly increased (RR 1.27 (95% CI: 1.23–1.31)), although the increase was trivial in absolute terms (2 per 1000). The subgroup analysis revealed that the risk was increased in each of the three trimesters. The risk of preterm preeclampsia among pregnant women receiving PPIs anytime during pregnancy was not significantly increased (RR 1.04 (95% CI: 0.70–1.55)). The certainty evaluated by GRADE in these estimates was low. PPI use may be associated with a trivial increase in the risk of preeclampsia in pregnant women. There is no evidence supporting that PPI use decreases the risk of preeclampsia or preterm preeclampsia.
Effect of a 3-Week Multidisciplinary Body Weight Reduction Program on the Epigenetic Age Acceleration in Obese Adults
Authors: Rigamonti Antonello E. , Bollati Valentina , Favero Chiara , Albetti Benedetta , Caroli Diana , Abbruzzese Laura , Cella Silvano G. , Sartorio Alessandro
Published: August 2022

Obesity and aging share common molecular and cellular mechanisms underlying the pathophysiology of cardiovascular diseases (CVD), which occur frequently in both conditions. DNA methylation (DNAm) age, a biomarker of the epigenetic clock, has been proposed as a more accurate predictor of biological aging than chronological age. A positive difference between an individual’s chronological age and DNAm age is referred to as epigenetic age acceleration. The objective of the present study was to evaluate the effects of a 3-week in-hospital body weight reduction program (BWRP) on the epigenetic age acceleration, as well as on other cardiometabolic outcomes, in a cohort of 72 obese adults (F/M: 43/29; (chronological) age: 51.5 ± 14.5 yrs; BMI: 46.5 ± 6.3 kg/m2). At the end of the BWRP, when considering the entire population, BMI decreased, and changes in body composition were observed. The BWRP also produced beneficial metabolic effects as demonstrated by decreases in glucose, insulin, HOMA-IR, total cholesterol, and LDL cholesterol. A post-BWRP improvement in cardiovascular function was also evident (i.e., decreases in systolic and diastolic blood pressures and heart rate). The BWRP reduced some markers of systemic inflammation, particularly C-reactive protein (CRP). Finally, vascular age (VA) and Framingham risk score (FRS) were reduced after the BWRP. When considering the entire population, DNAm age and epigenetic age acceleration did not differ after the BWRP. However, when subdividing the population into two groups based on each subject’s epigenetic age acceleration (i.e., ≤0 yrs or >0 yrs), the BWRP reduced the epigenetic age acceleration only in obese subjects with a value > 0 yrs (thus biologically older than expected). Among all the single demographic, lifestyle, biochemical, and clinical characteristics investigated, only some markers of systemic inflammation, such as CRP, were associated with the epigenetic age acceleration. Moreover, chronological age was correlated with DNAm age and VA; finally, there was a correlation between DNAm age and VA. In conclusion, a 3-week BWRP is capable of reducing the epigenetic age acceleration in obese adults, being the BWRP-induced rejuvenation evident in subjects with an epigenetic age acceleration > 0 yrs. Based on the BWRP-induced decrease in CRP levels, chronic systemic inflammation seems to play a role in mediating obesity-related epigenetic remodeling and biological aging. Thus, due to the strong association of CVD risk with the epigenetic clock and morbidity/mortality, any effort should be made to reduce the low-grade chronic inflammatory state in obesity.
Current Trends in Clinical Characteristics, Diagnosis, and Treatment of Polypoidal Choroidal Vasculopathy: A Perspective from Vietnam
Authors: Dat Dang , Hien Nguyen , Quan Nguyen , Tung Mai , Tam Hoang , Hung Bui
Published: August 2022

Polypoidal choroidal vasculopathy (PCV) is a common choroidal disease in the Asian population including Vietnam and is characterized by subretinal red-orange nodules, pigmented epithelium detachment, and massive subretinal hemorrhage. The recent focus on PCV in Vietnam can be attributed to advancements in PCV diagnosis and treatment. However, there is a scarcity of published literature and clinical data on PCV in the Vietnamese population, highlighting a key knowledge gap in this region. In order to address this gap, we gathered the opinions of experienced clinicians and retinal experts in Vietnam and reviewed available medical literature with the aim of: (i) providing an overview of PCV in the Vietnamese population—in terms of epidemiology, clinical characteristics, and management; (ii) tailoring international/national guidelines for the diagnosis and management of PCV, in line with available resources and medical equipment in Vietnam; and (iii) identifying gaps in clinical data in order to guide future PCV research in Vietnam and other countries with similar clinical conditions. The present review will enable healthcare providers and researchers to gain insight into current clinical practices and the limitations of PCV management in Vietnam and provide optimal and effective solutions.
Montreal Cognitive Assessment for Evaluating Cognitive Impairment in Subarachnoid Hemorrhage: A Systematic Review
Authors: Cornea Amalia , Simu Mihaela , Rosca Elena Cecilia
Published: August 2022

Subarachnoid hemorrhage (SAH) is a severe condition with high mortality and extensive long-term morbidity. Although research has focused mainly on physical signs and disability for decades, in recent years, it has been increasingly recognized that cognitive and psychological impairments may be present in many patients with SAH, negatively impacting their quality of life. We performed a systematic review aiming to provide a comprehensive report on the diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) test for evaluating the presence of cognitive impairment in patients with SAH. Using appropriate search terms, we searched five databases (PubMed, Scopus, PsychINFO, Web of Sciences, and Latin American and Caribbean Health Sciences Literature) up to January 2022. Two cross-sectional studies investigated the accuracy of MoCA in SAH patients in the subacute and chronic phase. We appraised the quality of the included studies using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) criteria. The MoCA test provides information about general cognitive functioning disturbances. However, a lower threshold than the original cutoff might be needed as it improves diagnostic accuracy, lowering the false positive rates. Further research is necessary for an evidence-based decision to use the MoCA in SAH patients.
Alginate-Based Bio-Composites and Their Potential Applications
Authors: Zdiri Khmais , Cayla Aurélie , Elamri Adel , Erard Annaëlle , Salaun Fabien
Published: August 2022

Over the last two decades, bio-polymer fibers have attracted attention for their uses in gene therapy, tissue engineering, wound-healing, and controlled drug delivery. The most commonly used bio-polymers are bio-sourced synthetic polymers such as poly (glycolic acid), poly (lactic acid), poly (e-caprolactone), copolymers of polyglycolide and poly (3-hydroxybutyrate), and natural polymers such as chitosan, soy protein, and alginate. Among all of the bio-polymer fibers, alginate is endowed with its ease of sol–gel transformation, remarkable ion exchange properties, and acid stability. Blending alginate fibers with a wide range of other materials has certainly opened many new opportunities for applications. This paper presents an overview on the modification of alginate fibers with nano-particles, adhesive peptides, and natural or synthetic polymers, in order to enhance their properties. The application of alginate fibers in several areas such as cosmetics, sensors, drug delivery, tissue engineering, and water treatment are investigated. The first section is a brief theoretical background regarding the definition, the source, and the structure of alginate. The second part deals with the physico-chemical, structural, and biological properties of alginate bio-polymers. The third part presents the spinning techniques and the effects of the process and solution parameters on the thermo-mechanical and physico-chemical properties of alginate fibers. Then, the fourth part presents the additives used as fillers in order to improve the properties of alginate fibers. Finally, the last section covers the practical applications of alginate composite fibers.
Personal Intelligence Is Evident in the Sophistication of People’s Narratives about Personality
Authors: Allen Jayne L. , Mayer John D.
Published: August 2022

Personal intelligence concerns the ability to understand personality in oneself and others—including the understanding of motives, socioemotional traits, and abilities. We examined if people’s scores on the ability-based Test of Personal Intelligence (TOPI) would be reflected in their narratives about someone whose personality they had learned about. In a Preliminary Study (N = 220), we collected narratives and open-ended descriptions about their learning. In Study 1 (N = 212), experts rated the respondents’ open-ended narratives for their sophistication about personality, defined as their knowledge and complexity of thought around the topic. Respondents also filled out checklists concerning what they learned and their relationship outcomes. Study 2 (N = 299) was a replication and extension in which we added the TOPI. Participants who scored higher on the TOPI produced narratives higher in Sophistication, even after statistical controls for Word Count and Vocabulary (the measures also were largely independent of the Big Five). The findings here may have applications for both testing and training.
Computer Engineering Education Experiences with RISC-V Architectures—From Computer Architecture to Microcontrollers
Authors: Jamieson Peter , Le Huan , Martin Nathan , McGrew Tyler , Qian Yicheng , Schonauer Eric , Ehret Alan , Kinsy Michel A.
Published: August 2022

With the growing popularity of RISC-V and various open-source released RISC-V processors, it is now possible for computer engineers students to explore this simple and relevant architecture, and also, these students can explore and design a microcontroller at a low-level using real tool-flows and implement and test their hardware. In this work, we describe our experiences with undergraduate engineers building RISC-V architectures on an FPGA and then extending their experiences to implement an Arduino-like RISC-V tool-flow and the respective hardware and software to handle input-output ports, interrupts, hardware timers, and communication protocols. The microcontroller is implemented on an FPGA as a Senior Design project to test the viability of such efforts. In this work, we will explain how undergraduates can achieve these experiences including preparation for these projects, the tool-flows they use, the challenges in understanding and extending a RISC-V processor with microcontroller functionality, and a suggestion of how to integrate this learning into an existing curriculum, including a discussion on if we should include these deeper experiences in the Computer Engineering undergraduate curriculum.
Effect of Hydrate Microscopic Distribution on Acoustic Characteristics during Hydrate Dissociation: An Insight from Combined Acoustic-CT Detection Study
Authors: Bu Qingtao , Xing Tongju , Li Chengfeng , Zhao Jinhuan , Liu Changling , Wang Zihao , Zhao Wengao , Kang Jiale , Meng Qingguo , Hu Gaowei
Published: August 2022

Geophysical detection techniques are important methods in marine gas hydrate exploration and monitoring, because the small-scale distribution of hydrates has a large impact on the wave velocity. The acoustic response characteristics of hydrate micro-distributions have strong significance for monitoring the hydrate dissociation process. In this paper, experiments simulating the hydrate dissociation process were carried out in a self-developed experimental device combining X-ray computed tomography (X-CT) scanning and ultrasonic detection, which allowed the acoustic wave characteristics and X-CT scanning results to be simultaneously obtained during the hydrate dissociation process. This study found that the hydrate dissociation stage is divided into three stages. The hydrate begins to dissociate at spots where it comes into touch with sand particles early in the dissociation process. The main factor affecting the acoustic wave velocity of hydrates in this stage is changes in the microscopic distribution of hydrate. In the middle stage, a large amount of hydrate decomposes, and the main factor affecting the acoustic wave velocity of hydrate in this stage is the change in hydrate content. In the later stage of hydrate dissociation, the hydrate distribution pattern consists mainly of the pore-filling type, and the hydrate micro-distribution at this stage is the main factor affecting the acoustic wave velocity. This study will be of great significance for understanding the microscopic control mechanism of hydrate reservoir geophysical exploration.
Resistance Characteristics and Improvement of a Pump-Jet Propelled Wheeled Amphibious Vehicle
Authors: Luo Hai , Ding Jiangming , Jiang Jiabing , Li Lingxun , Gong Jie , Lyu Ning
Published: August 2022

Pump-jets have a relatively high propulsion efficiency at medium speed and in heavy-load conditions for wheeled amphibious vehicles. However, the geometry of amphibious vehicles is very special due to the installation requirements of the pump-jet, which results in an obvious resistance on the wheels. In order to reduce the resistance of the amphibious vehicle, the resistance characteristics of the wheels are studied. Regarding a pump-jet-propelled wheeled amphibious vehicle, its wheel resistance characteristics in a wide speed range are firstly analyzed based on experiments and numerical simulations. By comparing the resistance of the amphibious vehicle with and without wheels, it is found that the hydrodynamic effect of wheels can increase the total resistance of the amphibious vehicle by 14~28%. Then, the wheel hydrodynamic effect is divided into local effect and global effect. By analyzing the changes in resistance, pressure distribution and streamline, the influence and hydro-mechanism of each effect are explored in detail. It is found that the longitudinal convex and concave structures formed by the wheels and wheel wells have a large negative effect on the total resistance. According to the hydro-mechanism, two resistance improvement approaches are proposed, which includes increasing wheel retraction and installing flat plates on the wheel well bottom. Finally, the ultimate resistance improvement model can reduce resistance by no less than 10% and power by on less than 8% in design speed.
Age, Growth and Population Structure Analyses of the Purpleback Flying Squid Sthenoteuthis oualaniensis in the Northwest Indian Ocean by Beak Microstructure
Authors: Lu Hua-Jie , Ou Yu-Zhe , He Jing-Ru , Zhao Mao-Lin , Chen Zi-Yue , Chen Xin-Jun
Published: August 2022

To explore the feasibility of using beak microstructure information to estimate the age of Sthenoteuthis oualaniensis, the microstructures of the upper beaks of individual squid were applied in this work to analyze the ages and growth patterns of squid caught from February–May 2019 and from October–December 2020 in the northwest Indian Ocean. The results indicated that the squid samples in the two years were no older than 9 months, and the samples in 2019 were autumn population and 2020 were spring population. The linear growth model of the autumn population (2019) was the best model for describing the relationship between age and ML, while the power model of the spring population (2020) was the best for describing the relationship between age and ML. The maximum instantaneous growth rate (IGR) and absolute daily growth rate (AGR) values of the spring population were 0.24%/d and 1.09 mm/d, respectively, occurring in squid between 200 and 220 days of age. The maximum IGR and AGR values of the autumn population were 0.69%/d and 1.73 mm/d, respectively, occurring in squid between 200 and 240 days of age. The period from 141–260 days (5–8 months) was considered to correspond to the subadult stage in the whole life history of S. oualaniensis in the Northwest Indian Ocean. The beak microstructure information can be effectively applied to estimate the age of S. oualaniensis individuals.
A New Compression and Storage Method for High-Resolution SSP Data Based-on Dictionary Learning
Authors: Yan Kaizhuang , Wang Yongxian , Xiao Wenbin
Published: August 2022

The sound speed profile data of seawater provide an important basis for carrying out underwater acoustic modeling and analysis, sonar performance evaluation, and underwater acoustic assistant decision-making. The data volume of the high-resolution sound speed profile is vast, and the demand for data storage space is high, which severely limits the analysis and application of the high-resolution sound speed profile data in the field of marine acoustics. This paper uses the dictionary learning method to achieve sparse coding of the high-resolution sound speed profile and uses a compressed sparse row method to compress and store the sparse characteristics of the data matrix. The influence of related parameters on the compression rate and recovery data error is analyzed and discussed, as are different scenarios and the difference in compression processing methods. Through comparative experiments, the average error of the sound speed profile data compressed is less than 0.5 m/s, the maximum error is less than 3 m/s, and the data volume is about 10% to 15% of the original data volume. This method significantly reduces the storage capacity of high-resolution sound speed profile data and ensures the accuracy of the data, providing technical support for efficient and convenient access to high-resolution sound speed profiles.
Healthcare Provider Testing Practices for Tinea and Familiarity with Antifungal-Drug-Resistant Tinea—United States, 2022
Authors: Benedict Kaitlin , Wu Karen , Gold Jeremy A. W.
Published: August 2022

Tinea, a dermatophyte fungal infection, is a common outpatient complaint that is easily misdiagnosed by visual inspection. Antifungal-drug-resistant tinea is an emerging global public health problem, with several cases reported in the United States. We analyzed data from a Spring 2022 web-based survey of healthcare provider attitudes and practices. Among 1500 healthcare providers, only 20.1% reported typically using diagnostic testing for tinea, and 19.5% reported clinical experience with drug-resistant tinea. Drug-resistant tinea may be more widespread than previously recognized. However, the low frequency of diagnostic testing indicates potential misunderstanding or misdiagnosis of drug-resistant tinea and missed opportunities to detect drug-resistant cases.
The Elongator Subunit Elp3 Regulates Development, Stress Tolerance, Cell Cycle, and Virulence in the Entomopathogenic Fungus Beauveria bassiana
Authors: Cai Qing , Wang Juanjuan , Xie Jiatao , Jiang Daohong , Keyhani Nemat O.
Published: August 2022

Transcriptional activity is mediated by chromatin remodeling, which in turn is affected by post-translational modifications, including histone acetylation. Histone acetyltransferases (HATs) are capable of promoting euchromatin formation and then activating gene transcription. Here, we characterize the Elp3 GNAT family HAT, which is also a subunit of Elongator complex, in the environmentally and economically important fungal insect pathogen, Beauveria bassiana. BbElp3 showed high localization levels to mitochondria, with some nuclear and cytoplasmic localization also apparent. Targeted gene knockout of BbElp3 resulted in impaired asexual development and morphogenesis, reduced tolerances to multiple stress conditions, reduced the ability of the fungus to utilize various carbon/nitrogen sources, increased susceptibility to rapamycin, and attenuated virulence in bioassays using the greater wax moth, Galleria mellonella. The ΔBbElp3 mutant also showed disrupted cell cycle, abnormal hyphal septation patterns, and enlarged autophagosomes in vegetative hyphae. Transcriptome analyses revealed differential expression of 775 genes (DEGs), including 336 downregulated and 438 upregulated genes in the ΔBbElp3 strain as compared to the wild type. Downregulated genes were mainly enriched in pathways involved in DNA processing and transcription, cell cycle control, cellular transportation, cell defense, and virulence, including hydrophobins, cellular transporters (ABC and MFS multidrug transporters), and insect cuticular degrading enzymes, while upregulated genes were mainly enriched in carbohydrate metabolism and amino acid metabolism. These data indicate pleiotropic effects of BbElp3 in impacting specific cellular processes related to asexual development, cell cycle, autophagy, and virulence.
The Retromer Subunit CfVps29 Is Involved in the Growth, Development, and Pathogenicity of Colletotrichum fructicola
Authors: Li Sizheng , Li Xiya , Li He
Published: August 2022

Camellia oleifera is an edible oil tree species native to China. Anthracnose is a common disease of Ca. oleifera, which reduces the production of the trees and brings huge economic losses. We have previously identified the fungus Colletotrichum fructicola as the major pathogen of anthracnose in Ca. oleifera. The retromer complex participates in the intracellular retrograde transport of the cargos from the endosome to the trans-Golgi network in the eukaryotes. Vacuolar protein sorting 29 is a subunit of the retromer complex. Targeted CfVPS29 gene deletion revealed that CfVps29 is involved in growth, conidiation, and the response to cell wall stress. We further found that the ΔCfvps29 mutant was minimally pathogenic to Ca. oleifera leaves, as a result of its defect in appressorium formation. This study illustrated the crucial functions of CfVps29 in the development, cell wall stress response, and pathogenicity of C. fructicola and, therefore, identified it as a potential fungicide target for the control of anthracnose.
Circumfusicillium cavernae gen. et sp. nov. (Bionectriaceae, Hypocreales) Isolated from a Hypogean Roman Cryptoporticus
Authors: Trovão João , Soares Fabiana , Paiva Diana Sofia , Tiago Igor , Portugal António
Published: August 2022

Stone monuments and relics are prone to biodeterioration processes prompted by microbial proliferation and activity. Among the distinct microbes capable of stone colonization, fungi are known to strongly contribute to stone biodeterioration. During the ongoing efforts aiming to study fungi thriving in dolomitic limestone walls of the Coimbra’s hypogean Roman cryptoporticus (Portugal), two unknown Bionectriaceae isolates were retrieved. The aim of this work was to depict the molecular and phenotypic characteristics of these microorganisms. The phylogenetic analyses revealed that the studied strains could not be assigned to any of the currently known Bionectriaceae genera. Moreover, the isolates exhibited distinctive and peculiar characteristics, such as the packing of conidia by surrounding hyphal segments and the formation of rope-like microsclerotia with a textura globose. Taking into account all the data obtained, a novel genus and species, Circumfusicillium cavernae gen. et sp. nov. in Bionectriaceae (Hypocreales), is proposed here.
Mepolizumab Improves Outcomes of Chronic Rhinosinusitis with Nasal Polyps in Severe Asthmatic Patients: A Multicentric Real-Life Study
Authors: Gallo Stefania , Castelnuovo Paolo , Spirito Luca , Feduzi Marta , Seccia Veronica , Visca Dina , Spanevello Antonio , Statuti Erica , Latorre Manuela , Montuori Claudio , Rizzi Angela , Boccabella Cristina , Bonini Matteo , De Corso Eugenio
Published: August 2022

Objective: The upcoming introduction of mepolizumab represents a promising treatment for chronic rhinosinusitis with nasal polyps (CRSwNP). The present study aimed to evaluate the effectiveness of mepolizumab on sinonasal outcomes of comorbid CRSwNP and severe asthma in a real-life setting. The primary endpoint was to evaluate changes in the SinoNasal Outcome Test (SNOT)-22 score, Nasal Polyp (NP) score, and blood eosinophil count during a 12-month treatment with mepolizumab. Secondary endpoints were to quantify mepolizumab’s effects on the mentioned parameters, identify clinical variables influencing the degree of response to treatment, and portray responder and nonresponder patients. Methods: A multicentric retrospective no-profit observational study on severe asthmatic patients, treated with mepolizumab, and comorbid CRSwNP was conducted. All patients were followed for at least 12 months. SNOT-22 score, NP score, and blood eosinophil count (and other CRS-specific variables) were collected at baseline and after 12 months. Results: Forty-three patients were included. A statistically significant reduction was observed for SNOT-22 score (mean t0 SNOT-22 54.8 ± 25.9; mean t12 SNOT-22 31.5 ± 21.3, p < 0.0001), NP score (median t0 NPS 3 (IQR 3); median t12 NPS 2 (IQR 4), p < 0.0001), and blood eosinophil count (mean t0 blood eosinophils 804.7 ± 461.5 cell/µL; mean t12 blood eosinophils 107.5 ± 104.6 cell/µL, p < 0.0001) after 12 months of treatment. Twenty patients (47%) gained improvement both in clinical and endoscopic outcome. Mepolizumab responder patients presented a t0 SNOT-22 significantly higher than nonresponders (p = 0.0011). Conclusions: Mepolizumab improved CRSwNP outcomes in a population of severe asthmatic patients. No clinical feature emerged to outline the profile of a “typical” responder patient, except for baseline SNOT-22 score, which seemed to affect the response to treatment. Further studies would be necessary to supplement these preliminary evaluations.