bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products
Authors: Mishchenko Natalia P. , Vasileva Elena A. , Gerasimenko Andrey V. , Grigorchuk Valeriya P. , Dmitrenok Pavel S. , Fedoreyev Sergey A.
Published: October 2020

Echinochrome A (Ech A, 1) is one of the main pigments of several sea urchin species and is registered in the Russian pharmacopeia as an active drug substance (Histochrome®), used in the fields of cardiology and ophthalmology. In this study, Ech A degradation products formed during oxidation by O2 in air-equilibrated aqueous solutions were identified, isolated, and structurally characterized. An HPLC method coupled with diode-array detection (DAD) and mass spectrometry (MS) was developed and validated to monitor the Ech A degradation process and identify the appearing compounds. Five primary oxidation products were detected and their structures were proposed on the basis of high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) as 7-ethyl-2,2,3,3,5,7,8-heptahydroxy-2,3-dihydro-1,4-naphthoquinone (2), 6-ethyl-5,7,8-trihydroxy-1,2,3,4-tetrahydronaphthalene-1,2,3,4-tetraone (3), 2,3-epoxy-7-ethyl-2,3-dihydro-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone (4), 2,3,4,5,7-pentahydroxy-6-ethylinden-1-one (5), and 2,2,4,5,7-pentahydroxy-6-ethylindane-1,3-dione (6). Three novel oxidation products were isolated, and NMR and HR-ESI-MS methods were used to establish their structures as 4-ethyl-3,5,6-trihydroxy-2-oxalobenzoic acid (7), 4-ethyl-2-formyl-3,5,6-trihydroxybenzoic acid (8), and 4-ethyl-2,3,5-trihydroxybenzoic acid (9). The known compound 3-ethyl-2,5-dihydroxy-1,4-benzoquinone (10) was isolated along with products 7–9. Compound 7 turned out to be unstable; its anhydro derivative 11 was obtained in two crystal forms, the structure of which was elucidated using X-ray crystallography as 7-ethyl-5,6-dihydroxy-2,3-dioxo-2,3-dihydrobenzofuran-4-carboxylic acid and named echinolactone. The chemical mechanism of Ech A oxidative degradation is proposed. The in silico toxicity of Ech A and its degradation products 2 and 7–10 were predicted using the ProTox-II webserver. The predicted median lethal dose (LD50) value for product 2 was 221 mg/kg, and, for products 7–10, it appeared to be much lower (≥2000 mg/kg). For Ech A, the predicted toxicity and mutagenicity differed from our experimental data.
[Bmim]Br Accelerated One-Pot Three-Component Cascade Protocol for the Construction of Spirooxindole–Pyrrolidine Heterocyclic Hybrids
Authors: Kumar Raju Suresh , M. Al-thamili Dhaifallah , Almansour Abdulrahman I. , Arumugam Natarajan , Dege Necmi
Published: October 2020

Our synthetic approach for the assembly of structurally complex spirooxindole heterocyclic hybrids was based on an ionic liquid, [bmim]Br mediated one-pot three-component cascade reaction strategy involving 1,3-dipolar cycloaddition reaction of N-1-(2-pyridinylmethyl)-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones and azomethine ylide generated in situ from isatin and L-phenyl alanine, affording a series of spirooxindole–pyrrolidine heterocyclic hybrids in good-to-excellent yields. In addition to serving as the reaction medium, [bmim]Br also functioned as a catalyst in this cycloaddition reaction and hence accelerated the reaction rate affording the cycloadducts in short reaction time.
Eco-Friendly Supercapacitors Based on Biodegradable Poly(3-Hydroxy-Butyrate) and Ionic Liquids
Authors: Migliorini Lorenzo , Santaniello Tommaso , Borghi Francesca , Saettone Paolo , Comes Franchini Mauro , Generali Gianluca , Milani Paolo
Published: October 2020

The interest for biodegradable electronic devices is rapidly increasing for application in the field of wearable electronics, precision agriculture, biomedicine, and environmental monitoring. Energy storage devices integrated on polymeric substrates are of particular interest to enable the large-scale on field use of complex devices. This work presents a novel class of eco-friendly supercapacitors based on biodegradable poly(3-hydroxybutyrrate) PHB, ionic liquids, and cluster-assembled gold electrodes. By electrochemical characterization, we demonstrate the possibility of tuning the supercapacitor energetic performance according to the type and amount of the ionic liquid employed. Our devices based on hydrophobic plastic materials are stable under cyclic operation and resistant to moisture exposure.
Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds
Authors: Markowska-Szczupak Agata , Endo-Kimura Maya , Paszkiewicz Oliwia , Kowalska Ewa
Published: October 2020

Titanium and its compounds are broadly used in both industrial and domestic products, including jet engines, missiles, prostheses, implants, pigments, cosmetics, food, and photocatalysts for environmental purification and solar energy conversion. Although titanium/titania-containing materials are usually safe for human, animals and environment, increasing concerns on their negative impacts have been postulated. Accordingly, this review covers current knowledge on the toxicity of titania and titanium, in which the behaviour, bioavailability, mechanisms of action, and environmental impacts have been discussed in detail, considering both light and dark conditions. Consequently, the following conclusions have been drawn: (i) titania photocatalysts rarely cause health and environmental problems; (ii) despite the lack of proof, the possible carcinogenicity of titania powders to humans is considered by some authorities; (iii) titanium alloys, commonly applied as implant materials, possess a relatively low health risk; (iv) titania microparticles are less toxic than nanoparticles, independent of the means of exposure; (v) excessive accumulation of titanium in the environment cannot be ignored; (vi) titanium/titania-containing products should be clearly marked with health warning labels, especially for pregnant women and young children; (vi) a key knowledge gap is the lack of comprehensive data about the environmental content and the influence of titania/titanium on biodiversity and the ecological functioning of terrestrial and aquatic ecosystems.
Chaotic Mixing Analyzing in Continuous Mixer with Tracing the Morphology Development of a Polymeric Drop
Authors: Chen Tao , Guo Hao , Li Guo , Ji Huajian , Xie Linsheng , Yang Yu
Published: October 2020

The chaotic mixing process in a continuous mixer plays an important role and has an essential influence on the performance of prepared materials. To reveal how a polymeric drop experienced the chaotic mixing and give more specific analysis about the chaotic mixing, the morphology development of a single drop was traced and recorded with an on-line visualization system. The drop would undergo elongation deformation, reorientation, and folding process, which were the typical signs of chaotic mixing. The elongation deformation was an important precondition for drop experiencing the reorientation and folding process and mainly existed in the region near the barrier, rotor tip clearance, and wedgelike region. The reorientation and folding process mostly appeared in the region near the rotor flat and interaction window. Besides, the erosion process of the drop was observed at the initial stage under lower rotor rotation speed. The chaotic mixing always held the dominant place in continuous mixer although the rotor rotation speed and drop viscoelasticity were adjusted. In this work, the chaotic mixing in a continuous mixer was dynamically presented. The dynamical results would give a more real and visual understanding of the chaotic mixing.
Parallel Manipulation Based on Stick-Slip Motion of Vibrating Platform
Authors: Mayyas Mohammad
Published: October 2020

The majority of the industrial material handling mechanisms used in the manipulation or assembly of mesoscale objects are slow and require precision programming and tooling, mainly because they are based on sequential robotic pick-n-place operations. This paper presents problem formation, modeling, and analysis of a sensorless parallel manipulation technique for mimicking real-systems that transfer mesoscale objects based on the vibration of inline-feeder machines. Unlike common stick-slip models that utilize a “mass-on-moving-belt” and avoid totality of the motion, the research obtains differential equations in order to describe the combined physics of stick-slip dynamics of an object traveling along an oscillating platform under smooth and dry friction conditions. The nonlinear dynamics are solved numerically to explain the effect of system parameters on the stick-slip motion. The research provides empirical models based on frequency-analysis identification to describe the total linear speed of an object to an input force. The results are illustrated and tested by time–response, phase plots, and amplitude response diagrams, which compare very favorably with results obtained by numerical simulation of the equation of motion, and this suggests that the vibration of the platform is independent of stick-slip motion when the mass of the object being transported is small relative to the mass of the system.
Security Requirements for the Internet of Things: A Systematic Approach
Authors: Pal Shantanu , Hitchens Michael , Rabehaja Tahiry , Mukhopadhyay Subhas
Published: October 2020

There has been a tremendous growth in the number of smart devices and their applications (e.g., smart sensors, wearable devices, smart phones, smart cars, etc.) in use in our everyday lives. This is accompanied by a new form of interconnection between the physical and digital worlds, commonly known as the Internet of Things (IoT). This is a paradigm shift, where anything and everything can be interconnected via a communication medium. In such systems, security is a prime concern and protecting the resources (e.g., applications and services) from unauthorized access needs appropriately designed security and privacy solutions. Building secure systems for the IoT can only be achieved through a thorough understanding of the particular needs of such systems. The state of the art is lacking a systematic analysis of the security requirements for the IoT. Motivated by this, in this paper, we present a systematic approach to understand the security requirements for the IoT, which will help designing secure IoT systems for the future. In developing these requirements, we provide different scenarios and outline potential threats and attacks within the IoT. Based on the characteristics of the IoT, we group the possible threats and attacks into five areas, namely communications, device/services, users, mobility and integration of resources. We then examine the existing security requirements for IoT presented in the literature and detail our approach for security requirements for the IoT. We argue that by adhering to the proposed requirements, an IoT system can be designed securely by achieving much of the promised benefits of scalability, usability, connectivity, and flexibility in a practical and comprehensive manner.
Label-Free Optical Resonator-Based Biosensors
Authors: Rho Donggee , Breaux Caitlyn , Kim Seunghyun
Published: October 2020

The demand for biosensor technology has grown drastically over the last few decades, mainly in disease diagnosis, drug development, and environmental health and safety. Optical resonator-based biosensors have been widely exploited to achieve highly sensitive, rapid, and label-free detection of biological analytes. The advancements in microfluidic and micro/nanofabrication technologies allow them to be miniaturized and simultaneously detect various analytes in a small sample volume. By virtue of these advantages and advancements, the optical resonator-based biosensor is considered a promising platform not only for general medical diagnostics but also for point-of-care applications. This review aims to provide an overview of recent progresses in label-free optical resonator-based biosensors published mostly over the last 5 years. We categorized them into Fabry-Perot interferometer-based and whispering gallery mode-based biosensors. The principles behind each biosensor are concisely introduced, and recent progresses in configurations, materials, test setup, and light confinement methods are described. Finally, the current challenges and future research topics of the optical resonator-based biosensor are discussed.
The Effects of Strength and Conditioning in Physical Education on Athletic Motor Skill Competencies and Psychological Attributes of Secondary School Children: A Pilot Study
Authors: Pullen Ben J. , Oliver Jon L. , Lloyd Rhodri S. , Knight Camilla J.
Published: October 2020

Leading global physical activity guidelines advocate that young children need to engage in activities that strengthen musculoskeletal tissues and improve movement skill competency. The purpose of this study was to examine the effects of delivering strength and conditioning as part of the physical education curriculum on athletic motor skill competencies (AMSC), physical performance, and psychosocial factors. Forty-six school children aged 11–14 were included in the study, and sub-divided firstly by sex and then into intervention and control groups. Intervention groups received nine lessons of strength and conditioning based activities over a six-week period, while the control groups continued with traditional physical education curricula. The resistance training skills battery (RTSB) and tuck jump assessment (TJA) assessed AMSC. Standing long jump distance assessed lower limb strength, and online surveys examined motivation, physical self-efficacy and self-esteem. Male and female intervention groups significantly improved RTSB (p > 0.05) whereas no changes were observed in the control groups. No changes were observed in the intervention groups TJA and only trivial and small non-significant changes in standing long jump performance. Significant increases in motivation of the male intervention group occurred. Strength and conditioning integrated in physical education can improve AMSC in short-term interventions.
Local Processing of Massive Databases with R: A National Analysis of a Brazilian Social Programme
Authors: Paz Hellen , Maia Mateus , Moraes Fernando , Lustosa Ricardo , Costa Lilia , Macêdo Samuel , Barreto Marcos E. , Ara Anderson
Published: October 2020

The analysis of massive databases is a key issue for most applications today and the use of parallel computing techniques is one of the suitable approaches for that. Apache Spark is a widely employed tool within this context, aiming at processing large amounts of data in a distributed way. For the Statistics community, R is one of the preferred tools. Despite its growth in the last years, it still has limitations for processing large volumes of data in single local machines. In general, the data analysis community has difficulty to handle a massive amount of data on local machines, often requiring high-performance computing servers. One way to perform statistical analyzes over massive databases is combining both tools (Spark and R) via the sparklyr package, which allows for an R application to use Spark. This paper presents an analysis of Brazilian public data from the Bolsa Família Programme (BFP—conditional cash transfer), comprising a large data set with 1.26 billion observations. Our goal was to understand how this social program acts in different cities, as well as to identify potentially important variables reflecting its utilization rate. Statistical modeling was performed using random forest to predict the utilization rated of BFP. Variable selection was performed through a recent method based on the importance and interpretation of variables in the random forest model. Among the 89 variables initially considered, the final model presented a high predictive performance capacity with 17 selected variables, as well as indicated high importance of some variables for the observed utilization rate in income, education, job informality, and inactive youth, namely: family income, education, occupation and density of people in the homes. In this work, using a local machine, we highlighted the potential of aggregating Spark and R for analysis of a large database of 111.6 GB. This can serve as proof of concept or reference for other similar works within the Statistics community, as well as our case study can provide important evidence for further analysis of this important social support programme.
Preparation of Porous Biochars by the Co-Pyrolysis of Municipal Sewage Sludge and Hazelnut Shells and the Mechanism of the Nano-Zinc Oxide Composite and Cu(II) Adsorption Kinetics
Authors: Chen Xi , Zhang Ran , Zhao Bing , Fan Guangjian , Li Haibo , Xu Xinyang , Zhang Mingchuan
Published: October 2020

Municipal sewage sludge (MSS) and hazelnut shells were selected for co-pyrolysis and chemically activated with K2CO3 in a N2 atmosphere. The biochar was then modified by photocatalysis. Hazelnut shells, as a solid waste, were selected as a carbon source additive because of its high cellulose content and similar structure to natural wood. Using hazelnut shells could increase the specific surface area, enhance the porosity, and improve the adsorption capacity of the biochar. Hazelnut shells could also reduce the content of heavy metals in the raw biochar materials, along with increasing the ecological security of biochar and contributing to its further development and utilization. FTIR was used to study the changes in the functional groups on the biochar surface. The layered porous structure of the biochar was observed by SEM. The Cu(II) adsorption capacity of the biochar was 42.28 mg/g after 24 h. The Langmuir and pseudo-second-order models effectively described Cu(II) adsorption.
Collapsing Wormholes Sustained by Dustlike Matter
Authors: Kashargin Pavel E. , Sushkov Sergey V.
Published: October 2020

It is well known that static wormhole configurations in general relativity (GR) are possible only if matter threading the wormhole throat is “exotic”—i.e., violates a number of energy conditions. For this reason, it is impossible to construct static wormholes supported only by dust-like matter which satisfies all usual energy conditions. However, this is not the case for non-static configurations. In 1934, Tolman found a general solution describing the evolution of a spherical dust shell in GR. In this particular case, Tolman’s solution describes the collapsing dust ball; the inner space-time structure of the ball corresponds to the Friedmann universe filled by a dust. In the present work we use the general Tolman’s solution in order to construct a dynamic spherically symmetric wormhole solution in GR with dust-like matter. The solution constructed represents the collapsing dust ball with the inner wormhole space-time structure. It is worth noting that, with the dust-like matter, the ball is made of satisfies the usual energy conditions and cannot prevent the collapse. We discuss in detail the properties of the collapsing dust wormhole.
Special Issue: Bovine Viral Diarrhea Virus and Related Pestiviruses
Authors: Bielefeldt-Ohmann Helle
Published: October 2020

The genus Pestivirus, encompassing small positive-strand RNA viruses in the family Flaviviridae, comprises four viruses of very significant economic impact to the cattle, swine and sheep industries worldwide: bovine viral diarrhoea virus (BVDV) type 1 and type 2, classical swine fever virus (CSFV) and border disease virus (BDV) [...]
Direito fundamental à ação popular e o princípio da solidariedade na defesa contra práticas abusivas das prestadoras de serviço público
Authors: Freitas Thaís Onofre Caixeta de , Weber Vinícius , Borges Gabriel Oliveira de Aguiar
Published: October 2020

O objeto do presente artigo trata de práticas abusivas realizadas por prestadoras de serviço público bem como da fundamentação adequada para que a Ação Popular possa ser utilizada como instrumento de controle contra as práticas abusivas realizadas pela administração pública, práticas estas, consideradas atentatórias à moralidade administrativa e inibitórias de direitos dos consumidores. Existe ainda uma jurisprudência proibitiva que impede que a ação popular seja utilizada no âmbito do Direito do Consumidor, contudo, o princípio da solidariedade também não pode ser cerceado, tendo em vista que é imprescindível para a regulação do Estado. O presente estudo trata de demonstrar a importância do princípio da solidariedade no âmbito do consumidor e sua convergência com a Ação popular. Trata ainda da Ação Popular não somente como um instrumento de controle, mas como um remédio constitucional capaz de coibir práticas abusivas e demonstra quais são os problemas enfrentados atualmente no âmbito do direito que impedem que tal ação seja utilizada no âmbito das relações de consumo.
Efeitos do CPAP em indivíduos com AVC e condição clínica de apneia obstrutiva do sono
Authors: Botelho Vasconcelos Josilaine , Bezan Castro Rodrigues dos Santos Júlia , Nascimento Venâncio Vanessa , Cecilio Hallak Regalo Simone , Rodrigues de Freitas Vianna Jacqueline , Fabrin Saulo Cesar Vallin
Published: October 2020

Introdução. O acidente vascular cerebral (AVC) é atualmente uma das principais causas de mortes e incapacidades no mundo, caracterizado por danos neurológicos que diminuem a qualidade de vida e, em muitos casos, provocam alterações respiratórias durante o sono, ocasionadas pela apneia obstrutiva do sono (AOS), sendo esta considerada um importante fator de risco. Diante disso, o objetivo do presente estudo é analisar a efetividade e os benefícios do uso da pressão positiva contínua nas vias aéreas (CPAP) em indivíduos com AVC que apresentam AOS. Método. Realizou-se uma revisão da literatura nas bases de dados Scielo, Bireme, PEDro, Medline e Pubmed, incluindo artigos publicados nos últimos dez anos, indexados na língua inglesa e portuguesa. Resultados. Os tratamentos com CPAP foram realizados com duração média de 4h/noite, com PEEP de 2 a 12cmH2O, sendo sua titulação realizada por oximetria de pulso, polissonografia ou por meio do AutoCPAP, apresentando redução nos índices de apneia-hipopneia, melhoria das escalas neurológicas e funcionais, com resultados significativos na qualidade do sono, eventos cardiovasculares e recorrências do AVC. Conclusão. O presente estudo sugere que o uso do CPAP em pacientes com AVC que possuem AOS é benéfico, sendo uma técnica eficaz nas comorbidades causadas por este distúrbio.
Local development factors from the organizational management perspective
Authors: Vergara-Romero Arnaldo , Sorhegui-Ortega Rafael
Published: October 2020

The evolution of local development, as a strategic axis for the development of a country, is the first component involved in the political speech and in regulatory protocols in the Ecuadorian territory, which has signed agreements with international multilateral organizations. The following article analyzes the social factors of local community formation as a social system and the management of the authorities of such community. As conclusion, it is indispensable the improvement of the local government system, the development of the studied resources and the opportunities to support social activity.
Single-Atom Nanozymes Linked Immunosorbent Assay for Sensitive Detection of A
β
1-40: A Biomarker of Alzheimer’s Disease
Authors: Lyu Zhaoyuan , Ding Shichao , Zhang Nan , Zhou Yang , Cheng Nan , Wang Maoyu , Xu Mingjie , Feng Zhenxing , Niu Xiangheng , Cheng Yuan , Zhang Chao , Du Dan , Lin Yuehe
Published: October 2020

Single-atom nanozymes (SANs) possess unique features of maximum atomic utilization and present highly assembled enzyme-like structure and remarkable enzyme-like activity. By introducing SANs into immunoassay, limitations of ELISA such as low stability of horseradish peroxidase (HRP) can be well addressed, thereby improving the performance of the immunoassays. In this work, we have developed novel Fe-N-C single-atom nanozymes (Fe-N
x
SANs) derived from Fe-doped polypyrrole (PPy) nanotube and substituted the enzymes in ELISA kit for enhancing the detection sensitivity of amyloid beta 1-40. Results indicate that the Fe-N
x
SANs contain high density of single-atom active sites and comparable enzyme-like properties as HRP, owing to the maximized utilization of Fe atoms and their abundant active sites, which could mimic natural metalloproteases structures. Further designed SAN-linked immunosorbent assay (SAN-LISA) demonstrates the ultralow limit of detection (LOD) of 0.88 pg/mL, much more sensitive than that of commercial ELISA (9.98 pg/mL). The results confirm that the Fe-N
x
SANs can serve as a satisfactory replacement of enzyme labels, which show great potential as an ultrasensitive colorimetric immunoassay.
YATIRIM HİZMET VE FAALİYETLERİNDEN YARARLANAN YATIRIMCILARIN TÜKETİCİ SIFATININ BELİRLENMESİ
Authors: TÖREMİŞ H. Ebru
Published: October 2020

Bu çalışma, Bilkent Üniversitesi Hukuk Fakültesi Özel Hukuk Doktora Programı kapsamında hazırlanan “Yatırım Hizmet ve Faaliyetleri Bağlamında Yatırımcının Tüketici Olarak Korunması” başlıklı doktora tezinden türetilmiştir. Çalışmanın amacı, yatırım hizmet ve faaliyetlerinden yararlanan yatırımcıların 7/11/2013 tarihli ve 6502 sayılı Tüketicinin Korunması Hakkında Kanun (TKHK) kapsamında “tüketici” sayılabilip sayılamayacağının tartışılmasıdır. Bu kapsamda, öncelikle sermaye piyasası mevzuatının yatırımcıların korunmasında eksik kalan yönleri tespit edilmiş, daha sonra 2008 finansal krizinin ardından yatırımcıların tüketici sayılmalarına ilişkin yeni yaklaşımlar açıklanmıştır. Bunu müteakip tüketici kavramı genel olarak irdelenmiş ve sermaye piyasası mevzuatının müşteri sınıflandırmaları esas alınarak, profesyonel ve genel müşteri sınıflarına giren hangi yatırımcıların tüketici sayılabileceği ortaya konulmuştur.
PENGARUH LEADER MEMBER EXCHANGE,DAN KEAHLIAN TEKNOLOGI INFORMASI TERHADAP KINERJA GURU SMP DI KABUPATEN PURWAKARTA
Authors: Patoni Patoni
Published: October 2020

This research manifests the effect of Leader Member Exchange, and Information Technology Expertise on the Performance of Middle School Teachers in Purwakarta Regency. The purpose of this study was to determine the effect of leader member exchange, and information technology expertise on the performance of junior high school teachers in Purwakarta with the research method used was descriptive analytical. The research data were obtained from questionnaires which were distributed directly to 95 teachers of state junior high schools in Purwakarta Regency, which were spread across 51 junior high schools through Google Form. Data processing was performed using the SPSS program version 24.0 which included a validity test, a reliability test, a correlation test, a multiple linear regression test, and a classic assumption test. The results showed that partially leader member exchange had a significant effect on the performance of junior high school teachers in Purwakarta by 54.40%, and information technology expertise significantly influenced the performance of junior high school teachers in Purwakarta by 49.30%. Simultaneously showed a significant influence of leader member exchange and information technology expertise on the performance of junior high school teachers in Purwakarta Regency by 64.21% and the remaining 35.79% was influenced by other factors not examined by researchers.
Penerapan Teknologi Informasi Sebagai Implementasi Standar Nasional Akreditasi Rumah Sakit (SNARS) Edisi 1 dalam Meningkatkan Program Mutu di Rumah Sakit (RS) Prima Husada
Authors: Endari Lovi Krissadi , Probowati Galuh Ajeng , Adipurna Resa Putra
Published: October 2020

Latar Belakang: Dewasa ini perkembangan dan kemajuan teknologi informasi berkembang pesat. Sistem aplikasi di berbagai bidang merupakan suatu keharusan bagi suatu instansi/perusahaan untuk memanfaatkan informasi sebagai basis administrasi dan pengolahan data. Sistem informasi rumah sakit memiliki peranan penting dalam pelayanan klinis dan administratif. Hal tersebut memicu adanya inovasi yang mendukung sistem manajemen data pengukuran mutu terintegrasi dengan cara mengintegrasikan Sistem Informasi Manajemen Rumah Sakit (SIMRS) dengan program mutu yang disebut SI PRIMA. SI PRIMA merupakan teknologi informasi yang telah diterapkan di Rumah Sakit Prima Husada. Teknologi ini merupakan sebuah inovasi baru dari Rumah Sakit Prima Husada dalam meningkatkan program mutu rumah sakit. Dengan diterapkannya sistem ini diharapkan mampu memberikan pengaruh positif dalam menjalankan proses pengumpulan data, analisis, serta validasi data mutu sehingga proses tersebut mampu berjalan secara efektif dan efisien.

Tujuan: Mengetahui penerapan SI PRIMA dalam meningkatkan program mutu di Rumah Sakit Prima Husada.

Metode: Observasional deskriptif dengan pendekatan kuantitatif yaitu membandingkan proses pengumpulan data, pelaporan data, dan validasi data mutu empat bulan sebelum menggunakan teknologi informasi dan empat bulan sesudah diterapkannya sistem teknologi informasi, dalam hal ini penulis dibantu oleh tim IT dan PMKP rumah sakit. Pengukuran proses yang dibandingkan adalah kecepatan waktu dan ketepatan input data. Pengukuran dini dilaksanakan pada bulan Oktober 2017 – Mei 2018.

Hasil: Pada periode empat bulan setelah diterapkan sistem teknologi informasi didapatkan peningkatan keakuratan dan efisiensi waktu untuk proses pengumpulan data dan pelaporan serta hasil validasi data 73.1%. Jumlah angka tersebut menunjukan peningkatan > 2x lipat apabila dibandingkan dengan periode empat bulan sebelum diberlakukan sistem teknologi informasi. Kenaikan validitas dikarenakan beberapa faktor salah satunya adalah tersedianya sistem informasi yang memungkinkan hasil data program mutu tidak perlu diproses secara manual namun secara terintegrasi.

Kesimpulan dan Saran: Pada penelitian ini didapatkan angka validitas indikator mutu meningkat signifikan setelah diterapkannya teknologi informasi daripada periode sebelumnya. Diperlukan penelitian lebih lanjut untuk menentukan apakah penerapan sistem teknologi informasi memiliki hubungan dalam peningkatan program mutu rumah sakit.
Meningkatkan Kesadaran Atas Resistensi Antimikroba di Rumah Sakit, Melalui Standar Akreditasi
Authors: Darmadjaja Djoni
Published: October 2020

KARS telah memasukkan edisi penyelenggaraan PPRA di rumah sakit sebagai standar akreditasi dalam Standar Nasional Akreditasi Rumah Sakit (SNARS) edisi 1 yang diberlakukan sejak 1 Januari 2018. Seluruh rumah sakit yang akan menjalani proses akreditasi, dipersyaratkan melakukan 5 kegiatan pokok dalam standar PPRA

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Modifikasi Manajemen Risiko Jatuh Pada Pasien Rawat Inap Psikogeriatri RSJ Dr. Radjiman Wediodiningrat Lawang
Authors: Sunarko Yuniar , Zamroni Muhammad , Kusumawardani Diah Ayu , Ayu Jennyla Puspitaning , Indahri Mariani , Amalia Etha Riska
Published: October 2020

Masalah Mutu: Jatuh adalah insiden keselamatan pasien yang sangat menonjol pada populasi pasien berusia lanjut dengan masalah psikogeriatrik di rumah sakit, sehingga manajemen risikonya tidak dapat disamakan dengan populasi umum. Berbagai karakteristik yang melekat pada populasi ini menyebabkan para Profesi Pemberi Asuhan (PPA) harus melakukan pengamatan yang seksama, merencanakan, implementasi, hingga mengevaluasi secara terus menerus. Pedoman Manajemen Risiko Jatuh yang ada di RSJ Dr. Radjiman Wediodiningrat Lawang (RSJRW) belum dapat mengakomodasi seluruh kebutuhan di atas.

Pilihan Solusi: Implementasi peningkatan mutu berkelanjutan dan konsep patient-centered care dalam manajemen risiko jatuh sehingga sesuai bagi populasi pasien psikogeriatrik di RSJRW.

Implementasi: Tim Pengembang Layanan Psikogeriatri bekerjasama dengan Komite Mutu dan Keselamatan Pasien melakukan modifikasi sebagai translasi hasil pengamatan dalam implementasi asesmen, reasesmen, penggunaan penanda risiko, integrasi proses asuhan, pendokumentasian, dan tindak lanjut pelaporan insiden yang berkaitan dengan risiko jatuh pada pasien rawat inap psikogeriatri di RSJRW.

Evaluasi dan Pembelajaran: Proses yang melibatkan PPA multidisipliner ini berhasil menurunkan angka kejadian pasien jatuh dari 1,5% (2016) menjadi 0,8% (2017), dan 0% (2018). Komunikasi efektif dan komitmen semua pihak mendasari semua proses pembelajaran berkelanjutan ini, sementara pendokumentasian menggunakan sistem informasi teknologi menjadi katalisator perubahan-perubahan yang terjadi.
Asesmen Pra-Anestesi: Bukan Sekedar Kepatuhan
Authors: Agustina Else , Wardhani Viera , Astari Asti Melani
Published: October 2020

Latar Belakang: Asesmen praanestesi adalah prosedur penting yang bertujuan untuk memastikan keamanan tindakan bedah yang akan dilakukan. Prosedur ini sebenarnya adalah tanggung jawab dokter anestesiologi. Namun, dalam prosesnya melibatkan dokter, perawat serta pasien dan keluarganya.

Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran pelaksanaan asesmen praanestesi serta menggali praktik pendelegasian tugas (task shifting) dalam pelaksanaan asesmen praanestesi di ruangan rawat inap.

Metode: Penelitian ini dilakukan di sebuah rumah sakit (RS) tipe C (140 tempat tidur) di kota Malang Jawa Timur. Peneliti melakukan observasi selama 11 hari terhadap pelaksanaan asesmen praanestesi pada kasus operasi elektif. Untuk melengkapi data, dilakukan juga pengamatan terhadap dokumen rekam medis pasien yang sama. Untuk menilai praktik pendelegasian tugas dari dokter ke perawat, peneliti menggunakan kuesioner yang berisi 28 aspek aktivitas asesmen praanestesi. Kuesioner ini didistribusikan kepada 80 orang responden yang terdiri dari perawat dan dokter spesialis yang terlibat dalam operasi elektif. Kuesioner ini menilai persepsi responden mengenai harapan dan kenyataan tentang siapa yang seharusnya melaksanakan aktivitas tersebut. Data dianalisis secara deskriptif untuk menggambarkan pola pelaksanaan pendelegasian tugas dan asesmen praanestesi.

Hasil: Asesmen praanestesi hanya dilakukan pada 19,5% dari total 43 kasus operasi elektif, namun tidak satupun yang menuliskan hasil asesmen pada dokumen yang semestinya. Dokumen rekam medis tentang asesmen praanestesi akan dilengkapi saat setelah pelaksanaan operasi (di kamar operasi). Sebagian besar responden beranggapan bahwa asesmen praanestesi dilaksanakan secara kolaborasi antara dokter dan perawat. Namun, dalam praktiknya, kebanyakan aktivitas dalam asesmen praanestesi dilakukan oleh perawat. Pendelegasian tertinggi dari dokter ke perawat terjadi pada aspek meminta tanda tangan persetujuan tindakan medis (informed consent) serta aspek menjelaskan tentang puasa kepada pasien dan keluarganya.

Kesimpulan: Asesmen praanestesi belum terdokumentasi dengan lengkap dan tepat sebelum pelaksanaan operasi, serta terjadi pendelegasian tugas ke perawat terutama pada proses persetujuan tindakan medis.
Corona Virus dan Manajemen Mutu Pelayanan Klinis di Rumah Sakit
Authors: Djasri Hanevi
Published: October 2020

Badan Kesehatan Dunia (WHO) telah mengeluarkan pedoman tatalaksana infeksi saluran pernapasan akut berat (severe acute respiratory infection/SARI) yang diduga karena COVID-19. Pedoman tersebut ditujukan untuk para dokter yang merawat pasien di rumah sakit untuk memberikan kemudahan akses terhadap panduan terkini dalam rangka memastikan tatalaksana terbaik bagi pasien.

Pedoman tersebut memuat: 1) proses triage untuk mengenali dan menyortir pasien dengan SARI; 2) tindakan segera untuk pencegahan dan pengendalian infeksi dengan tepat; 3) pemberian terapi dan pemantauan; 4) pengumpulan spesimen untuk diagnosis laboratorium; 5) tatakelola gagal napas hipoksemia dan sindrom gangguan pernapasan akut acute respiratory distress syndrome/ARDS); 6) manajemen syok septik; 7) pencegahan komplikasi; 8) perawatan khusus anti COVID-19; dan pertimbangan khusus untuk pasien hamil.

Sebagai pengelola rumah sakit, ketersediaan pedoman internasional ini perlu dicermati, diadopsi menjadi pedoman klinis (clinical guidelines), diterapkan dan dievaluasi sebagai bagian dari manajemen mutu pelayanan klinis. Dalam standar akreditasi rumah sakit di Indonesia, penyusunan dan penerapan pedoman klinis memang disyaratkan dalam bentuk Panduan Praktik Klinis (PPK), terlebih untuk tatalaksana pasien dengan risiko tinggi. Standar akreditasi juga meminta agar PPK juga menjadi dasar untuk melakukan evaluasi mutu dan keselamatan asuhan pasien yang diberikan oleh setiap klinisi.
Application of Dynamic Voltage Restorer for Enhancing low voltage Ride-through capability of Doubly Fed Induction Generator
Authors:   Associate Professor, College of Engineering, Thiruvanathapuram, India, Samina T.
Published: October 2020

Doubly Fed Induction Generator (DFIG) based wind Energy System are very sensitive to grid disturbance such as Symmetrical voltage sag. In this paper the authors propose a new method for application of Dynamic Voltage Restorer for enhancing the low voltage ride through capability of wind turbine driven Doubly Fed Induction Generator.
Humanist Diplomat in Early 16th Century Hungary: Hieronymus Balbus
Authors: Bárány Attila
Published: October 2020

The article investigates new sources, Western European, mainly English diplomatic reports – several being so far unknown for Hungarian scholarship, or, if known, not examined in this regard – e.g. held at the British Library Manuscript Collection to shed light on Hungarian-Ottoman relations at the eve of the fall of the “shield of Christendom”, Belgrade in 1521. The article follows the mission of Hieronymus Balbus, an Italian at the diplomatic personnel of Jagiellonian Hungary, in 1521 to the Habsburg, Tudor and Valois courts. Balbus’s diplomatic workings – through the embassy to the Emperor (Charles V in Worms and Brussels), a peace conference at Calais and Cardinal Wolsey and Henry VIII, King of England – has not been adequately seen in Hungarian historiography, and some of his letters and political activity ranging from Bruges, Worms, Calais, London and Cologne has not so far been mapped, yet new insights can be given for the understanding of Louis II’s diplomatic efforts during the stress of the siege and loss of Belgrade in 1521. The investigation is largely based on Balbus’s dispatches – which has not survived in Hungarian archival material but were preserved in the reports of English envoys of his activity, to the maker of Tudor policy, Chancellor Wolsey. The correspondence of Balbus provides valuable information on the administration of Louis II, about its relationship with the Turks and the Emperor. The leaders of Hungarian diplomacy did not lack astuteness and “had a clear picture” about the international power relations. The government experimented with alternatives, provided they did not receive any aid from the Habsburgs: they were willing to go as far as making an alliance with not only the English, but even with the Emperor’s enemies, the Valois. In 1521, despite the powerful Habsburg dominance, Hungarian foreign politics did have some room to manoeuvre.
Jenő Bánó
Authors: Venkovits Balázs
Published: October 2020

This paper introduces a case study of Hungarian emigration to the Americas, which illustrates some of the general trends in migration at the turn of the century as well as a unique career path of a Hungarian immigrant in Mexico. By discussing and analyzing the life, diplomatic career, and publications of Jenő Bánó, the paper touches upon issues including the significance of travel writing in influencing migration, the use of migration propaganda, and relations between Hungary and the Americas.
Role of Infliximab in Immune Checkpoint Inhibitor-Induced Pneumonitis
Authors: Lai Kathryn A. , Sheshadri Ajay , Adrianza Andres M. , Etchegaray Mikel , Balachandran Diwakar D. , Bashoura Lara , Shannon Vickie R. , Faiz Saadia A.
Published: October 2020

Introduction

Since immune checkpoint inhibitor (ICI) blockade has become standard therapy for many cancers, immune-related adverse events (irAEs) have increased. ICI-pneumonitis is infrequent but potentially fatal. In cases not responsive to corticosteroids, additional immunosuppression is recommended. Data for use of infliximab in ≥ grade 3 pneumonitis is sparse.

Materials and Methods

A retrospective review of patients who received infliximab for ICI-pneumonitis from March 2016 to October 2018 was performed. Clinical characteristics were reviewed.

Results

Nine patients (44% women) with ≥ grade 3 pneumonitis were included. Concurrent/prior irAEs were present in 55%. Bronchoscopy was performed in 67%. Median corticosteroid dose was 1.2 mg/kg prior to infliximab, and time from administration of corticosteroids to infliximab ranged from 2 to 34 days. Four patients improved, but the remainder died.

Conclusion

We report improvement of ICI-pneumonitis with infliximab in 4 out of 9 patients in a small, retrospective cohort. Further prospective randomized controlled trials are needed.
Improvement of Regulatory Calculation of the Load-Carrying Capacity of Vibrated, Centrifuged, and Vibrocentrifuged-Based Iron-Concrete Columns with Variatropic Structure
Authors: Маилян Л. Р. , Стельмах С. А. , Щербань Е. М. , Чернильник А. А.
Published: October 2020

Состояние проблемы. Сжатые железобетонные элементы изготавливаются по трем основным технологиям - вибрированием, центрифугированием и виброцентрифугированием. Однако все основные расчетные зависимости для определения их несущей способности выведены, исходя из основного постулата - постоянства и равенства характеристик бетона по сечению, что соответствует действительности лишь в вибрированных колоннах. Результаты. Разработан усовершенствованный нормативный подход к расчету прочности центрифугированных и виброцентрифугированных железобетонных колонн, заключающийся в использовании в расчете интегральных или дифференциальных характеристик бетона. Выводы. Расчет прочности коротких центрально сжатых вибрированных, центрифугированных и виброцентрифугированных колонн по усовершенствованному нормативному подходу дал наилучшие результаты с использованием дифференциальных характеристик бетона, различающихся по сечению.

Statement of the problem. Compressed reinforced concrete elements are manufactured according to three main technologies - vibrating, centrifuging and vibrocentrifugation. However, all the main calculated dependences for determining their load-bearing capacity were derived based on the main postulate - the constancy and equality of the characteristics of concrete over the cross section, which corresponds to reality only in vibrated columns. Results. An improved regulatory approach has been developed for calculating the strength of centrifuged and vibrocentrifuged reinforced concrete columns, which involves using the calculation of integral or differential characteristics of concrete. Conclusions. Strength analysis of short centrally compressed vibrated, centrifuged and vibrocentrifuged columns using an improved regulatory approach yielded the best results using differential characteristics of concrete varying in cross section.
Analysis Supply Chain Management (SCM) Planning of Juice Production by UKM Larasati
Authors: Mudhifatul Jannah Urnika , Rahmawati Zurriat Nyndia
Published: October 2020

Jaringan Supply Chain Management atau rantai pasok merupakan konsep yang membahas tentang aliran barang, uang dan informasi secara berkelanjutan yang bertujuan untuk membantu proses perkembangan sebuah usaha. Salah satu bidang usaha yang menunjang perekonomian daerah adalah Usaha Kecil dan Menengah (UKM). Di era ini UMKM diharapkan mampu memiliki nilai tambah untuk bersaing dalam hal menunjukkan eksistensi di pasar regional.

Demikian halnya yang dihadapi oleh Usaha Kecil Menengah (UKM) yang dikelolan oleh Kelompok Wanita Tani (KWT) Larasati di Desa Palaan, Kecamatan Ngajum, Kabupaten Malang. Saat ini usaha yang dikelola oleh KWT Larasati adalah  produksi minuman sari buah kemasan cup. Buah yang digunakan adalah markisa, sirsak, apel, jeruk, dan nanas.

Penelitian ini bertujuan untuk menganalisa manajemen rantai pasok Minuman Sari Buah KWT Larasati, serta mengatasi masalah manajemen resiko dan peningkatan nilai tambah pada rantai pasok produk minuman sari buah KWT Larasati di Desa Palaan. Metode pengumpulan data yang digunakan yaitu wawancara, observasi, kuesioner, dan studi pustaka. Responden kuesioner yakni anggota KWT Larasi sebanyak 30 orang.

Hasil dari penelitian ini adalah identifikasi Supply Chain Management (SCM) serta solusi untuk manajemen rantai pasok yang terintegrasi dengan elemen-elemen pemilihan pemasok, perencanaan logistik, proses produksi, dan pendistribusian pasokan. Hal ini dapat dijadikan acuan UKM Produk Minuman Sari Buah KWT Larasati untuk meningkatkan nilai tambah dan pendapatan.
PENGARUH PENGALAMAN WISATAWAN TERHADAP KEPUASAN DAN KEPERCAYAAN SERTA NIAT BERKUNJUNG KEMBALI
Authors: Pujiastuti Eny Endah
Published: October 2020

In contemporary marketing, the intention to revisit has become the main key in research so that tourists do not move to other destinations. intention to revisit tourist areas is influenced by many factors. The problem and purpose of this research is to  analyze and prove the influence of tourist experience, satisfaction, trust in the intention to revisit intention. Destination Nature Posong Temanggung became a research location. Tourists who have visited once to the destination become a research sample. The data collected were 124 questionnaires, processed using SEM AMOS. The concluesion of te study shows that tourist’s experience satisfaction and trust direcly influence the intention to revisit. Implications of research findings such as managers provide positive experiences to tourists so that tourists are satisfied and trust the destination so they will visit again. Research limitations such as a number of samples have not been able to generalize the conclusions as a whole. Suggestions for further research, researchers recommended to increase the number of samples of various ages so that they can provide a complete model as a guide for managers to develop destinations.
Dual-complex Jacobsthal Quaternions
Authors: TORUNBALCI AYDIN Fügen
Published: October 2020

In this paper, dual-complex Jacobsthal quaternions are defined. Also, some algebraic properties of dual-complex Jacobsthal quaternionswhich are connected with dual-complex numbers and Lucas numbers are investigated. Furthermore, the Honsberger identity, the d'Ocagne'sidentity, Binet's formula, Cassini's identity, Catalan's identity for these quaternions and their real representations are given.............................................................................................................................................
A Study of the Replacement of Natural Coarse Aggregate by Spherically-Shaped and Crushed Waste Cathode Ray Tube Glass in Concrete
Authors:   The National University of Malaysia, Pauzi N. N. M. , Karim M. R. ,   Dhaka University of Engineering & Technology, Jamil M. ,   The National University of Malaysia, Hamid R. ,   The National University of Malaysia, Zain M. F. M. ,   The National University of Malaysia
Published: October 2020

The aim of this study is to conduct an experimental investigation on the influence of complete replacement of natural coarse aggregate with spherically-shape and crushed waste cathode ray tube (CRT) glass to the aspect of workability, density, and compressive strength of the concrete. After characterizing the glass, a group of concrete mixes was prepared to contain a 40% spherical CRT glass and 60% crushed CRT glass as a complete (100%) replacement of natural coarse aggregates. From a total of 16 types of concrete mixes, the optimum proportion was selected based on its best performance. The test results showed that the use of spherical and crushed glass that possesses a smooth surface, rounded, irregular and elongated shape, and low water absorption affects the workability of concrete. Due to a higher specific gravity of crushed glass, concrete mixes containing CRT glass had a higher density compared to ordinary concrete. Despite the spherical and crushed CRT glass being stronger than gravel, the results revealed a reduction in compressive strength of the concrete. However, using a lower water to binder (w/b) ratio and a higher superplasticizer (SP) dosage, it is found to enhance the compressive strength of 60.97 MPa at 28 days that is lower by 13% than the control specimen. These findings indicate that waste CRT glass in the form of spherical and crushed could be used as an alternative of coarse aggregate that may pave the way for the disposal of hazardous e-waste.