bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Trends and Developments in the Modernisation of the Aviation Training System
Authors: KALIYEVA Gulzhan K. , KONAKBAY Zarina , ASILBEKOVA Indira , ABZHAPBAROVA Ainur , ZHARDEMKYZY Saltanat
Published: December 2022

The relevance of the study is related to the increasingly important role of air transport in recent years. The need for training in civil aviation has been identified as an integral and key component in improving the performance of civil aviation and its services. Today, the transport industry occupies an important position in the economy of any country since the development of transport has a competitive impact on the economy. Air transportation in the Republic of Kazakhstan significantly affects the state of the national economy and occupies a certain share in the structure of GDP. In recent years, the development of the state with its geographical location and low population density requires an increase in air transport facilities. Consequently, population movements and the burden of economic development, along with the establishment of relations between regions, are becoming an increasingly necessary service every year. The purpose of the study is to investigate the issues of training specialists in civil aviation by analysing the current situation in the aviation industry in Kazakhstan. The development of small and regional aviation is one of the main tasks of the civil aviation industry of the Republic of Kazakhstan to enable the population of remote settlements to access large centres of macrostructures, solve urgent and emergency situations, and perform agricultural and chemical activities. In this regard, appropriate measures are being taken to make local airports capable of accommodating aircraft from 10 to 50 tonnes. The economic status of state aviation, the growth of consumer markets and the growth rate of changes in international requirements of ISO, IACO, IATO have revealed systemic problems in civil aviation, among which the quality training for the civil aviation specialists is an important one. The practical significance is the transformation and adjustment of current trends and modernisations into educational standards, followed by the formation of a competence model in air transport training.
Experimental research of hydraulic cylinder with the built-in throttle for steering the front landing gear wheel
Authors: NICOLIN Bogdan Adrian , NICOLIN Ilie
Published: December 2022

This paper presents the experimental research method of a hydraulic cylinder used for steering the front landing gear wheel. A mechanical-hydraulic steering system is operated by two interchangeable hydraulic cylinders acting in tandem to rotate the movable sub-assembly that contains the front landing gear wheel. Each hydraulic cylinder is designed with a built-in throttle to equalize the speed of the hydraulic cylinder rod traveling in both directions of movement (extension and retraction). During the experiments, three constructive variants of the built-in throttle will be used to obtain the optimal variant.
Development and Automation of Fixed Wing UAV for Reconnaissance Mission with FPV Capability
Authors: PREM ANAND T. P. , ABISHEK K. , KRISHNA KAILASH R. , NITHIYANANTHAM K. K.
Published: December 2022

Today's military missions require pre-emptive knowledge of hostile activities in and around the conflict zone. Using a multi rotor UAV for Reconnaissance has many disadvantages, such as cost, range, reduced maneuverability and much more. The main objective is to make the UAV completely autonomous, with the transmitter on standby. By entering the flight plan into the Ground Control System, the UAV will complete the assigned mission autonomously and will be guided by an operational flight plan wherein active waypoints are plotted in the GCS. The GCS can be linked to the Telemetry and the Global Positioning System to have a complete knowledge of the UAV location.
Did COVID-19 Make Me an Afro-Pessimist? A Conversation in Three Parts
Authors: Kwakye Chamara Jewel , Millward Jessica
Published: December 2022

As the COVID-19 pandemic continues to rage and disproportionately affect BIPOC, we keep count of the death toll around the world, in the U.S., in our own communities and in our own families. How can we have a “wish to live,” while so many around us die? Does a space exist between fateful (faithful) optimism present in Aretha Franklin’s, “Mary Don’t You Weep?” and the ever-present power structure, that as Reverend Al Sharpton noted, has always had its knee on our necks? More concretely, how do we reconcile what Aisha Durham discusses as “weathering and wounded,” as we sit in the space of being both and not wanting to endure much more. This piece articulates some of the conversations that we have stumbled upon, worked through and raged against from the space of our collective homes and fatigued spirits. It addresses notions of Afro-Pessimism and the intersection of Black Feminist Theory, the role that grief plays in Black Feminist praxis, the role of Diaspora in the historical imagination, and asks the question, “Did COVID and the state-sanctioned killings of Black people make us Afro-Pessimists?”
Discontinuous phase unwrapping based on the minimization of Zernike gradient polynomial residual
Authors: Yang Xi , Hu Haixiang , Xue Donglin , Zhang Xin
Published: December 2022

In many certain optical metrology cases, the pupil is usually divided into multiple connected domains by secondary mirror spiders, thus producing segment piston errors and leaving a false phase unwrapping result. In this paper, a method based on minimization of Zernike gradient polynomial residual (MZGR) is proposed to estimate segment piston errors and correct erroneous phase unwrapping results. Simulations and experiments demonstrated that this method can obtain the segment piston errors precisely under complex aberration forms and varied obscurations, indicating reliable practicality. Comparison to the 4D commercial solution, the RMS (root-mean-square) of the residual decreased from 0.154 λ to 0.020 λ.
Simultaneous Brillouin and piezoelectric coupling to a high-frequency bulk acoustic resonator
Authors: Yoon Taekwan , Mason David , Jain Vijay , Chu Yiwen , Kharel Prashanta , Renninger William H. , Collins Liam , Frunzio Luigi , Schoelkopf Robert J. , Rakich Peter T.
Published: December 2022

Bulk acoustic resonators support robust, long-lived mechanical modes, capable of coupling to various quantum systems. In separate works, such devices have achieved strong coupling to both superconducting qubits, via piezoelectricity, and optical cavities, via Brillouin interactions. In this work, we present a hybrid microwave–optical platform capable of coupling to bulk acoustic waves through cavity-enhanced piezoelectric and photoelastic interactions. The modular, tunable system achieves fully resonant and well-mode-matched interactions among a 3D microwave cavity, a high-frequency bulk acoustic resonator, and a Fabry–Perot cavity. We realize this piezo–Brillouin interaction in x-cut quartz, demonstrating the potential for strong optomechanical interactions and high cooperativity using optical cavity enhancement. We further show how this device functions as a bidirectional electro–opto–mechanical transducer, with transduction efficiency exceeding

10

−
8

, and a feasible path towards unity conversion efficiency. The high optical sensitivity and ability to apply a large resonant microwave field in this system also offers a tool for probing anomalous electromechanical couplings, which we demonstrate by investigating (nominally centrosymmetric)

C
a
F

2

and revealing a parasitic piezoelectricity of 83 am/V. Such studies are an important topic for emerging quantum technologies, and highlight the versatility of this hybrid platform.
ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex
Authors: Semprich Claudia I. , Davidson Lindsay , Amorim Torres Adriana , Patel Harshil , Briscoe James , Metzis Vicki , Storey Kate G.
Published: December 2022

Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear. Moreover, for differentiation to progress, FGF signalling must decline. Why these signalling dynamics are required has not been determined. Here, we show that dephosphorylation of the FGF effector kinase ERK1/2 rapidly increases chromatin accessibility at neural genes in mouse embryos, and, using ATAC-seq in human embryonic stem cell derived spinal cord precursors, we demonstrate that this occurs genome-wide across neural genes. Importantly, ERK1/2 inhibition induces precocious neural gene transcription, and this involves dissociation of the polycomb repressive complex from key gene loci. This takes place independently of subsequent loss of the repressive histone mark H3K27me3 and transcriptional onset. Transient ERK1/2 inhibition is sufficient for the dissociation of the repressive complex, and this is not reversed on resumption of ERK1/2 signalling. Moreover, genomic footprinting of sites identified by ATAC-seq together with ChIP-seq for polycomb protein Ring1B revealed that ERK1/2 inhibition promotes the occupancy of neural transcription factors (TFs) at non-polycomb as well as polycomb associated sites. Together, these findings indicate that ERK1/2 signalling decline promotes global changes in chromatin accessibility and TF binding at neural genes by directing polycomb and other regulators and appears to serve as a gating mechanism that provides directionality to the process of differentiation.
Plausible pathway for a host-parasite molecular replication network to increase its complexity through Darwinian evolution
Authors: Kamiura Rikuto , Mizuuchi Ryo , Ichihashi Norikazu
Published: December 2022

How the complexity of primitive self-replication molecules develops through Darwinian evolution remains a mystery with regards to the origin of life. Theoretical studies have proposed that coevolution with parasitic replicators increases network complexity by inducing inter-dependent replication. Particularly, Takeuchi and Hogeweg proposed a complexification process of replicator networks by successive appearance of a parasitic replicator followed by the addition of a new host replicator that is resistant to the parasitic replicator. However, the feasibility of such complexification with biologically relevant molecules is still unknown owing to the lack of an experimental model. Here, we investigated the plausible complexification pathway of host-parasite replicators using both an experimental host-parasite RNA replication system and a theoretical model based on the experimental system. We first analyzed the parameter space that allows for sustainable replication in various replication networks ranging from a single molecule to three-member networks using computer simulation. The analysis shows that the most plausible complexification pathway from a single host replicator is the addition of a parasitic replicator, followed by the addition of a new host replicator that is resistant to the parasite, consistent with the previous study by Takeuchi and Hogeweg. We also provide evidence that the pathway actually occurred in our previous evolutionary experiment. These results provide experimental evidence that a population of a single replicator spontaneously evolves into multi-replicator networks through coevolution with parasitic replicators.
Chronic clinical signs of upper respiratory tract disease associate with gut and respiratory microbiomes in a cohort of domestic felines
Authors: Arnold Holly Kristin , Hanselmann Rhea , Duke Sarah M. , Sharpton Thomas J. , Beechler Brianna R.
Published: December 2022

Feline upper respiratory tract disease (FURTD), often caused by infections etiologies, is a multifactorial syndrome affecting feline populations worldwide. Because of its highly transmissible nature, infectious FURTD is most prevalent anywhere cats are housed in groups such as animal shelters, and is associated with negative consequences such as decreasing adoption rates, intensifying care costs, and increasing euthanasia rates. Understanding the etiology and pathophysiology of FURTD is thus essential to best mitigate the negative consequences of this disease. Clinical signs of FURTD include acute respiratory disease, with a small fraction of cats developing chronic sequelae. It is thought that nasal mucosal microbiome changes play an active role in the development of acute clinical signs, but it remains unknown if the microbiome may play a role in the development and progression of chronic clinical disease. To address the knowledge gap surrounding how microbiomes link to chronic FURTD, we asked if microbial community structure of upper respiratory and gut microbiomes differed between cats with chronic FURTD signs and clinically normal cats. We selected 8 households with at least one cat exhibiting chronic clinical FURTD, and simultaneously collected samples from cohabitating clinically normal cats. Microbial community structure was assessed via 16S rDNA sequencing of both gut and nasal microbiome communities. Using a previously described ecophylogenetic method, we identified 136 and 89 microbial features within gut and nasal microbiomes respectively that significantly associated with presence of active FURTD clinical signs in cats with a history of chronic signs. Overall, we find that nasal and gut microbial community members associate with the presence of chronic clinical course, but more research is needed to confirm our observations.
Poison frog dietary preference depends on prey type and alkaloid load
Authors: Moskowitz Nora A. , D’Agui Rachel , Alvarez-Buylla Aurora , Fiocca Katherine , O’Connell Lauren A.
Published: December 2022

The ability to acquire chemical defenses through the diet has evolved across several major taxa. Chemically defended organisms may need to balance chemical defense acquisition and nutritional quality of prey items. However, these dietary preferences and potential trade-offs are rarely considered in the framework of diet-derived defenses. Poison frogs (Family Dendrobatidae) acquire defensive alkaloids from their arthropod diet of ants and mites, although their dietary preferences have never been investigated. We conducted prey preference assays with the Dyeing Poison frog (Dendrobates tinctorius) to test the hypothesis that alkaloid load and prey traits influence frog dietary preferences. We tested size preferences (big versus small) within each of four prey groups (ants, beetles, flies, and fly larvae) and found that frogs preferred interacting with smaller prey items of the fly and beetle groups. Frog taxonomic prey preferences were also tested as we experimentally increased their chemical defense load by feeding frogs decahydroquinoline, an alkaloid compound similar to those naturally found in their diet. Contrary to our expectations, overall preferences did not change during alkaloid consumption, as frogs across groups preferred fly larvae over other prey. Finally, we assessed the protein and lipid content of prey items and found that small ants have the highest lipid content while large fly larvae have the highest protein content. Our results suggest that consideration of toxicity and prey nutritional value are important factors in understanding the evolution of acquired chemical defenses and niche partitioning.
Effect of different electrostimulation currents on female urinary incontinence: A protocol of a randomized controlled trial
Authors: Escandiusi Avramidis Raissa , Barbosa Angélica Mércia Pascon , Thomaz de Aquino Nava Guilherme , Hikaru Nagami Danielle , Prudencio Caroline Baldini , Rodrigues Pedroni Cristiane
Published: December 2022

Introduction

Urgency urinary incontinence (UUI) is characterized by involuntary urine leakage immediately after reporting of sudden, compelling desire to void. Electrostimulation and non-invasive neuromodulation have been considered as the first and third line of UUI treatment but there is a lack of consensus on which parameters are more efficient. Thus, this study aims to compare the effect of low versus medium frequency currents on urinary incontinence severity and quality of life in women with UUI complains.

Methods

It will be a randomized controlled trial with 5 arms, double-blinded (outcome assessor and statistician). The study was approved by the Research Ethics Committee (CAAE: 11479119.9.0000.5406) and has been prospectively registered on the Brazilian Registry of Clinical Trials (RBR-8bkkp6). Concerning, double-blind process, the blinded assessor will be responsible for evaluate primary and secondary outcomes at baseline and follow-up without information about allocation and the statistician will perform analyses without information about group codification. One hundred and five participants will be randomized to receive: (1) Transcutaneous tibial nerve stimulation-low frequency, (2) Transcutaneous tibial nerve stimulation-high frequency, (3) Aussie median frequency, (4) Interferencial median frequency or (5) High voltage stimulation. The application will be performed during 20 sessions of 45-minutes, twice a week for 10 weeks, in groups of maximum 5 participants. The participants will be evaluated before treatment (baseline- 0 week), during the treatment (5 weeks) and after the last treatment session (10 weeks). The primary outcomes measures will be UI severity and quality of life, and the secondary outcome will be pelvic floor strength. Statistical analysis will be performed using SPSS software version 24.0 for Windows (IBM Corp., Armonk, N.Y., USA). The variables will be described by the mean and 95% confidence interval. The distribution of normality will be analyzed by the Shapiro-Wilk test. ANOVA for repeated measures will be performed. Mauchly’s test the hypothesis of sphericity and when if this violated the hypotheses, the analyses will be based on the Greenhouse-Geisser test. Peer-to-peer comparisons will be performed using the Bonferroni Post-Hoc test. The significant level adopted will be 5% (p ≤ 0.05).

Conclusion

This study will enhance knowledge about effect of different neuromodulation currents in the improvement of UUI.
Wheelchair skill tests in wheelchair Basketball: A systematic review
Authors: Ferreira da Silva Carlos Mariano Aguiar , de Sá Karina Santos Guedes , Bauermann Andreia , Borges Mariane , de Castro Amorim Minerva , Rossato Mateus , Gorla José Irineu , de Athayde Costa e Silva Anselmo
Published: December 2022

Objectives

The aim of this study was to identify, describe and synthesize the skill tests used in wheelchair basketball.

Method

A systematic review was carried out in the databases: PubMed/Medline, ScienceDirect, Scopus, Web of science and Google Scholar from inception to January 2021 with up to date in January 2022. the eligibility criteria used were Inclusion: (i) evaluation of wheelchair basketball athletes; (ii) using skill tests (defined as agility, speed, ball maneuverability, slalom, etc.) and (iii) papers needed to be written in English and published in peer-reviewed journals. Exclusion: (i) papers with poor description of the test methodology, (ii) participants not classified as wheelchair basketball athletes (less than one year of practice) and (iii) Participants were not people without disabilities.

Results

Our main findings were: a) the most explored skills were pass and speed, and the most frequent test was the pass tests and sprint tests, b) Strong associations were found between sports classes and performance in field tests, c) The most used tests for each skill were: pass = pass accuracy and maximum pass; speed = 20m sprint test with and without the ball; agility = slalom test; dribbling = obstacle dribbling tests and throw = free throw and spot shot.

Conclusion

The most explored skills were passing and speed, and to evaluate these skills we highlight the two-handed chest pass test, 20m sprint test with ball and the WMP test. The use of specific tests can facilitate the creation of reference standards and possible comparison of athletes and, thus, enable better training conditions, aiming to meet the specific demands of each athlete and team.
Bioactive extracts and association with C and N in Eleutherococcus senticosus subjected to chitosan nanoparticles in contrasting light spectra
Authors: Guo Shenglei , Wang Hexiang , Sui Yawen , Liu Xiubo , Tan Long
Published: December 2022

Bioactive compounds are major reasons for the value of Eleutherococcus senticosus, which can be modified by different lighting spectra. Light-emitting diode (LED) provides lights with specific spectra which can interact with other treatments to impact plant bioactive production. Chitosan nanoparticle (CN) is a biopolymer derived from marine creatures. It’s usage may be a practical approach to cope with uncertainties in secondary metabolites induced by illumination. Carbon (C) and nitrogen (N) cyclings link plant eco-physiological performance and bioactive substance; hence their associations may reveal the mechanism of joint light-CN interaction. In this study, E. senticosus seedlings were raised under artificial lighting spectra from high-pressure sodium (HPS) lamps (44% red, 55% green, 1% blue) and white (44% red, 47% green, 8% blue) and red colored (73% red, 13% green, 14% blue) LED panels. Half of the seedlings received CN and the other half received distilled water as the control. Compared to the HPS spectrum, the red-light induced stronger shoot growth with greater biomass accumulation and higher water uptake but resulted in lower N concentration and biomass ratio in the root. The white light caused more biomass allocated to the root and strengthened stem C concentration. Stem eleutheroside B increased with shoot growth, while root eleutheroside B had a positive association with leaf C and stem protocatechuic acid had a negative association with leaf N. Having the CN treatment in white and red LED lights is recommended for increasing accumulation of bioactive compounds in the shoots and roots of E. senticosus seedlings, respectively.
New insights on patterns of genetic admixture and phylogeographic history in Iberian high mountain populations of midwife toads
Authors: Lucati Federica , Miró Alexandre , Bosch Jaime , Caner Jenny , Jowers Michael Joseph , Rivera Xavier , Donaire-Barroso David , Rebelo Rui , Ventura Marc
Published: December 2022

Multiple Quaternary glacial refugia in the Iberian Peninsula, commonly known as “refugia within refugia”, allowed diverging populations to come into contact and admix, potentially boosting substantial mito-nuclear discordances. In this study, we employ a comprehensive set of mitochondrial and nuclear markers to shed light onto the drivers of geographical differentiation in Iberian high mountain populations of the midwife toads Alytes obstetricans and A. almogavarii from the Pyrenees, Picos de Europa and Guadarrama Mountains. In the three analysed mountain regions, we detected evidence of extensive mito-nuclear discordances and/or admixture between taxa. Clustering analyses identified three major divergent lineages in the Pyrenees (corresponding to the eastern, central and central-western Pyrenees), which possibly recurrently expanded and admixed during the succession of glacial-interglacial periods that characterised the Late Pleistocene, and that currently follow a ring-shaped diversification pattern. On the other hand, populations from the Picos de Europa mountains (NW Iberian Peninsula) showed a mitochondrial affinity to central-western Pyrenean populations and a nuclear affinity to populations from the central Iberian Peninsula, suggesting a likely admixed origin for Picos de Europa populations. Finally, populations from the Guadarrama Mountain Range (central Iberian Peninsula) were depleted of genetic diversity, possibly as a consequence of a recent epidemic of chytridiomycosis. This work highlights the complex evolutionary history that shaped the current genetic composition of high mountain populations, and underscores the importance of using a multilocus approach to better infer the dynamics of population divergence.
Validating emergency department cardioversion procedures in provincial administrative data in Ontario, Canada
Authors: Atzema Clare L. , Stiell Ian G. , Chong Alice S. , Austin Peter C.
Published: December 2022

Background

Cardioversion of acute-onset atrial fibrillation (AF) via electrical or pharmacological means is a common procedure performed in many emergency departments. While these procedures appear to be very safe, the rarity of subsequent adverse outcomes such as stroke would require huge sample sizes to confirm that conclusion. Big data can supply such sample sizes.

Objective

We aimed to validate several potential codes for successful emergency department cardioversion of AF patients.

Methods

This study combined 3 observational datasets of emergency department AF visits seen at one of 26 hospitals in Ontario, Canada, between 2008 and 2012. We linked patients who were eligible for emergency department cardioversion to several province-wide health administrative datasets to search for the associated cardioversion billing and procedural codes. Using the observational data as the gold standard for successful cardioversion, we calculated the test characteristics of a billing code (Z437) and of procedural codes 1.HZ.09JAFS and 1.HZ.09JAJS. Both include pharmacological and electrical cardioversions, as well as unsuccessful attempts; the latter is <10% using electricity (in Canada, standard practice is to proceed to electrical cardioversion if pharmacological cardioversion is unsuccessful).

Results

Of 4557 unique patients in the three datasets, 2055 (45.1%) were eligible for cardioversion. Nine hundred thirty-three (45.4%) of these were successfully cardioverted to normal sinus rhythm. The billing code had slightly better test characteristics overall than the procedural codes. Positive predictive value (PPV) of a billing was 89.8% (95% CI, 87.0–92.2), negative predictive value (NPV) 70.5% (95% CI, 68.1–72.8), sensitivity 52.1% (95% CI, 48.8–55.3), and specificity 95.1% (95% CI, 93.7–96.3).

Conclusions

AF patients who have been successfully cardioverted in an emergency department can be identified with high PPV and specificity using a billing code. Studies that require high sensitivity for cardioversion should consider other methods to identify cardioverted patients.
A multicategory logit model detecting temporal changes in antimicrobial resistance
Authors: Aerts Marc , Tzu-yun Teng Kendy , Jaspers Stijn , Sanchez Julio Alvarez
Published: December 2022

Monitoring and investigating temporal trends in antimicrobial data is a high priority for human and animal health authorities. Timely detection of temporal changes in antimicrobial resistance (AMR) can rely not only on monitoring and analyzing the proportion of resistant isolates based on the use of a clinical or epidemiological cut-off value, but also on more subtle changes and trends in the full distribution of minimum inhibitory concentration (MIC) values. The nature of the MIC distribution is categorical and ordinal (discrete). In this contribution, we developed a particular family of multicategory logit models for estimating and modelling MIC distributions over time. It allows the detection of a multitude of temporal trends in the full discrete distribution, without any assumption on the underlying continuous distribution for the MIC values. The experimental ranges of the serial dilution experiments may vary across laboratories and over time. The proposed categorical model allows to estimate the MIC distribution over the maximal range of the observed experiments, and allows the observed ranges to vary across labs and over time. The use and performance of the model is illustrated with two datasets on AMR in Salmonella.
Effects of portable air cleaners and A/C unit fans on classroom concentrations of particulate matter in a non-urban elementary school
Authors: Azevedo Alexandra , Liddie Jahred , Liu Jason , Schiff Jessica E. , Adamkiewicz Gary , Hart Jaime E.
Published: December 2022

Given the increased use of air cleaners as a prevention measure in classrooms during the COVID-19 pandemic, this study aimed to investigate the effects of portable air cleaners with HEPA filters and window A/C fans on real-time (1 minute) concentrations of PM less than 2.5 microns (PM2.5) or less than 1 microns (PM1.0) in two classrooms in a non-urban elementary school in Rhode Island. For half of each school day, settings were randomized to “high” or “low” for the air cleaner and “on” or “off” for the fan. Descriptive statistics and linear mixed models were used to evaluate the impacts of each set of conditions on PM2.5 and PM1.0 concentrations. The mean half-day concentrations ranged from 3.4–4.1 μg/m3 for PM2.5 and 3.4–3.9 μg/m3 for PM1.0. On average, use of the fan when the air cleaner was on the low setting decreased PM2.5 by 0.53 μg/m3 [95% CI: -0.64, -0.42] and use of the filter on high (compared to low) when the fan was off decreased PM2.5 by 0.10 μg/m3 [95% CI: -0.20, 0.005]. For PM1.0, use of the fan when the air cleaner was on low decreased concentrations by 0.18 μg/m3 [95% CI: -0.36, -0.01] and use of the filter on high (compared to low) when the fan was off decreased concentrations by 0.38 μg/m3 [95% CI: -0.55, -0.21]. In general, simultaneous use of the fan and filter on high did not result in additional decreases in PM concentrations compared to the simple addition of each appliance’s individual effect estimates. Our study suggests that concurrent or separate use of an A/C fan and air cleaner in non-urban classrooms with low background PM may reduce classroom PM concentrations.
Changes in the determinants and spatial distribution of under-five stunting in Bangladesh: Evidence from Bangladesh Demographic Health Surveys (BDHS) 1996–97, 2014 and 2017/18
Authors: Saha U. R. , van Wesenbeeck C. F. A.
Published: December 2022

Background

Bangladesh has experienced tremendous change in child nutrition over the past few decades, but there are large differences between different regions in progress made. The question is whether continuation of current policies will bring the progress needed to reach national and international targets on child nutrition security.

Data and methods

Using national data BDHS 1996/97, 2014, and 2017, this study attempts to map such reductions across Bangladesh and to explore the distribution of covariate effects (joint effects) that are associated with childhood stunting over these two periods, overall and by region. The main contribution of this paper is to link observed stunting scores to a household profile. This implies that different variables are evaluated jointly with stunting to assess the likelihood of being associated with stunting.

Results

Overall, the covariates: ‘Parental levels of education’, ‘children older than one year old’, ‘children live in rural area’, ‘children born at home’ formed the country winning profile in 1996/97, whereas parental levels of education disappear in the winning profile for children stunted in 2014. This implies that over the years, Bangladesh has been successful in addressing parental education for long-term reductions in child undernutrition. In addition, the diversity of profiles of households with stunted children increases over time, pointing at successful targeting of policies to increase food security among children over the period. However, in areas where improvements have been insignificant, also the profiles remain stable, indicating a failure of policies to reach the target populations. The analysis for 2017 confirms this picture: the diversity of profiles remains high, with little change in the dominant profiles.

Conclusion

Further decline in stunting is possible through region specific multipronged interventions, targeting children older than one year among vulnerable groups, in addition with strengthening family planning programs as larger families also have a higher risk to have stunted children. In general, the profiles in 2014 and 2017/18 are much more diverse than in 1996, which can be explained by the relative success of specific targeted policies in some divisions, while being much less successful in other regions. In sum, our results suggest that the challenge lies in the implementation of policies, rather than in the generic approach and assumed theory of change.
The COVID-19 impacts on bikeshare systems in small rural communities: Case study of bikeshare riders in Montgomery County, VA
Authors: Almannaa Mohammed , Woodson Cat , Ashqar Huthaifa , Elhenawy Mohammed
Published: December 2022

The shared and micro-mobility industry (ride sharing and hailing, carpooling, bike and e-scooter shares) saw direct and almost immediate impacts from COVID-19 restrictions, orders and recommendations from local governments and authorities. However, the severity of that impact differed greatly depending on variables such as different government guidelines, operating policies, system resiliency, geography and user profiles. This study investigated the impacts of the pandemic regarding bike-share travel behavior in Montgomery County, VA. We used bike-usage dataset covering two small towns in Montgomery county, namely: Blacksburg and Christiansburg, including Virginia Tech campus. The dataset used covers the period of Jan 2019—Dec 2021 with more than 14,555 trips and 5,154 active users. Findings indicated that a bikeshare user’s average trip distance and duration increased in 2020 (compared to 2019) from 2+ miles to 4+ and from half an hour to about an hour. While there was a slight drop in 2021, bikeshare users continued to travel farther distances and spend more time on the bikes than pre-COVID trips. When those averages were unpacked to compare weekday trips to weekend trips, a few interesting trip patterns were observed. Unsurprisingly, more trips still took place on the weekends (increasing from 2x as many trips to 4x as many trips than the weekday). These findings could help to better understand traveler’s choices and behavior when encountering future pandemics.
Psychological distress among people living with chronic medical illness and the general population, Northwest Ethiopia: A comparative cross-sectional study
Authors: Tareke Minale , Bayeh Agegnehu Berie , Birhanu Minyichil , Belete Amsalu
Published: December 2022

Background

Psychological distress is often linked to and negatively affects the outcomes of chronic medical conditions; however, data on psychological distress and its predictors among individuals with chronic medical illnesses are scarce in developing countries like Ethiopia. The main objective of this study was to assess the magnitude and predictors of psychological distress among people living with chronic medical illness and the general population.

Methods

A comparative cross-sectional study was conducted in Mecha demographic research center, Northwest Ethiopia. The participants were selected from the general population and outpatient departments. Kessler-10 (K-10) was used to assess psychological distress.

Result

The magnitude of psychological distress among people living with chronic medical illness and those from the general population was 62.0% and 35.1%, respectively. The odds of psychological distress in people living with chronic medical illness was three times more than the one in the general population. Divorced marital status, family history of chronic medical illness, and low social support were statistically significantly associated with psychological distress in both groups.

Conclusion

The magnitude of psychological distress was significantly higher among people living with chronic medical illness. Routine screening of such cases for psychological distress during their visits for their medical illness helps take appropriate therapeutic interventions.
How does new infrastructure impact the competitiveness of the tourism industry?——Evidence from China
Authors: Yan Guodong , Zou Lin , Liu Yunan , Ji Ruxue
Published: December 2022

Infrastructure construction related to the new generation of information technology and 5G technology is an important measure taken by the Chinese government to promote regional economic development. Large-scale infrastructure investment is being carried out simultaneously in China’s core and peripheral regions. The COVID-19 pandemic has dealt a severe blow to China’s tourism industry, and the application of new technologies seems to blur the spatial boundaries of the tourism industry. Therefore, it is debatable whether the zealous development of large investment projects can really improve the competitiveness of the regional tourism industry. This paper discusses this topical issue by empirically analyzing data from 31 Chinese provinces and cities from 2008–2019 and draws the following conclusions (1) The continuous expansion of new infrastructure investment in China indeed has a positive effect on improving China’s overall tourism competitiveness. However, the inverted U-shaped relationship between the two shows that China should not blindly expand the scale of infrastructure construction and make appropriate investment according to the regional industrial development level. (2) Although convergent infrastructure plays an important role in regional industrial competitiveness, the marginal effect has begun to weaken, so the problem of scale inefficiency needs to be addressed. In contrast, the input of innovation infrastructure is insufficient to enhance industrial competitiveness and can be moderately increased to achieve better results. (3) China’s core economic areas have a good driving effect on new infrastructure investment, but the original technological innovation and transformation-type facilities are still the key to limiting the improvement of industrial competitiveness. Peripheral areas are more passive recipients with strong demand. Therefore, investment in various types of infrastructure can drive regional development.
Depressive symptoms and HIV risk behaviours among adolescents enrolled in the HPTN071 (PopART) trial in Zambia and South Africa
Authors: Shanaube Kwame , Gachie Thomas , Hoddinott Graeme , Schaap Albertus , Floyd Sian , Mainga Tila , Bond Virginia , Hayes Richard , Fidler Sarah , Ayles Helen ,   on behalf of the HPTN071 (PopART) Study Team
Published: December 2022

Background

Mental health is a critical and neglected public health problem for adolescents in sub-Saharan Africa. In this paper we aim to determine the prevalence of depressive symptoms and the association with HIV risk behaviours in adolescents aged 15–19 years in Zambia and SA.

Methods

We conducted a cross-sectional survey from August-November 2017 in seven control communities of HPTN 071 (PopART) trial (a community-randomised trial of universal HIV testing and treatment), enrolling approximately 1400 eligible adolescents. HIV-status was self-reported. Depressive symptoms were measured with the Short Mood and Feelings Questionnaire (SMFQ), with a positive screen if adolescents scored ≥12. We fitted a logistic regression model to identify correlates of depressive symptoms with subgroup analyses among those who self-reported ever having had sex, by gender and country.

Results

Out of 6997 households approached, 6057 (86.6%) were enumerated. 2546 adolescents were enumerated of whom 2120 (83.3%) consented to participate and were administered the SMFQ. The prevalence of depressive symptoms was 584/2120 (27.6%) [95%CI: 25.7%-29.5%]. Adolescents in SA were less likely to experience depressive symptoms (Adjusted Odds Ratio [AOR] = 0.63 (95% CI: 0.50, 0.79), p-value<0.0001).

Female adolescents (AOR = 1.46 (95% CI: 1.19, 1.81), p-value<0.0001); those who reported ever having sex and being forced into sex (AOR = 1.80 (95% CI: 1.45, 2.23), p-value<0.001) and AOR = 1.67 (95% CI: 0.99, 2.84); p-value = 0.057 respectively) were more likely to experience depressive symptoms. Among 850 (40.1%) adolescents who self-reported to ever having had sex; those who used alcohol/drugs during their last sexual encounter were more likely to experience depressive symptoms (AOR = 2.18 (95% CI: 1.37, 3.47); p-value = 0.001), whereas those who reported using a condom were less likely to experience depressive symptoms (AOR = 0.74 (95% CI: 0.55, 1.00); p-value = 0.053).

Conclusion

The prevalence of depressive symptoms among adolescents ranged from 25–30% and was associated with increased HIV-risk behaviour.
Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis
Authors: Meier Stuart , Seddon James A. , Maasdorp Elizna , Kleynhans Léanie , du Plessis Nelita , Loxton Andre G. , Malherbe Stephanus T. , Zak Daniel E. , Thompson Ethan , Duffy Fergal J. , Kaufmann Stefan H. E. , Ottenhoff Tom H. M. , Scriba Thomas J. , Suliman Sara , Sutherland Jayne S. , Winter Jill , Kuivaniemi Helena , Walzl Gerhard , Tromp Gerard ,   GC6-74 Consortium,   Catalysis TB Biomarkers Consortium
Published: December 2022

Mycobacterium tuberculosis(M.tb) causes tuberculosis (TB) and remains one of the leading causes of mortality due to an infectious pathogen. Host immune responses have been implicated in driving the progression from infection to severe lung disease. We analyzed longitudinal RNA sequencing (RNAseq) data from the whole blood of 74 TB progressors whose samples were grouped into four six-month intervals preceding diagnosis (the GC6-74 study). We additionally analyzed RNAseq data from an independent cohort of 90 TB patients with positron emission tomography-computed tomography (PET-CT) scan results which were used to categorize them into groups with high and low levels of lung damage (the Catalysis TB Biomarker study). These groups were compared to non-TB controls to obtain a complete whole blood transcriptional profile for individuals spanning from early stages ofM.tbinfection to TB diagnosis. The results revealed a steady increase in the number of genes that were differentially expressed in progressors at time points closer to diagnosis with 278 genes at 13–18 months, 742 at 7–12 months and 5,131 detected 1–6 months before diagnosis and 9,205 detected in TB patients. A total of 2,144 differentially expressed genes were detected when comparing TB patients with high and low levels of lung damage. There was a large overlap in the genes upregulated in progressors 1–6 months before diagnosis (86%) with those in TB patients. A comprehensive pathway analysis revealed a potent activation of neutrophil and platelet mediated defenses including neutrophil and platelet degranulation, and NET formation at both time points. These pathways were also enriched in TB patients with high levels of lung damage compared to those with low. These findings suggest that neutrophils and platelets play a critical role in TB pathogenesis, and provide details of the timing of specific effector mechanisms that may contribute to TB lung pathology.
Willingness to participate in geolocation-based research
Authors: Ochoa Gómez Carlos
Published: December 2022

Among the new research possibilities offered by smartphones, collecting geolocation data (e.g., GPS coordinates) holds a prominent position, allowing the investigation of individuals’ mobility with greater precision and less effort than conventional data collection methods. However, geolocation data are still affected by errors (e.g., inaccurate recorded locations) and limitations (e.g., inability to record the purpose of a trip). Sending a survey right in the moment an event of interest is detected using geolocation data can add the missing information, while reducing memory errors that typically affect conventional surveys (sent some days/weeks after). However, the possibilities offered by both geolocation data and in-the-moment surveys triggered by geolocation data are limited by individuals’ willingness to participate. This paper assesses such willingness using a conjoint experiment carried out on a sample of 1,016 members of an opt-in online panel in Spain. The effects on such willingness to accept the conditions offered to participants and their personal characteristics are also studied. The results show that asking panelists to participate in in-the-moment surveys does not negatively affect willingness compared to only sharing geolocation data. However, the conditions offered to panelists for their participation (mainly project duration and incentives) have a strong influence on their willingness. Furthermore, panelists less concerned with privacy and safety, and more experienced in sharing social media content, installing apps and using Google Maps, are more willing to participate. Finally, answers to open questions reveal that the main reason for participating is getting the incentive, while not participating is primarily related to privacy issues.
Estimating the effects of crime maps on house prices using an (Un)natural experiment: A study protocol
Authors: Zhang Meng Le , Adepeju Monsuru , Thomas Rhiannon
Published: December 2022

Street-level crime maps are publicly available online in England and Wales. However, there was initial resistance to the publication of such fine-grained crime statistics, which can lower house prices and increase insurance premiums in high crime neighbourhoods. Identifying the causal effect of public crime statistics is difficult since crime statistics generally mirror actual crime. To address this question empirically, we would ideally experiment and introduce a source of random variation in the crime statistics. For instance, we could randomly increase or decrease the number of offences displayed in crime statistics and measure their effects on local house prices. For obvious reasons, we cannot pursue this research design. However, street-level crime maps contain intentional errors, which are the product of a geomasking algorithm designed to mask the location of crimes and protect the identity of victims. This project leverages features associated with the geomasking algorithm to estimate the effect of public crime statistics on house prices.
Ribitol dose-dependently enhances matriglycan expression and improves muscle function with prolonged life span in limb girdle muscular dystrophy 2I mouse model
Authors: Wu Bo , Drains Morgan , Shah Sapana N. , Lu Pei Juan , Leroy Victoria , Killilee Jessalyn , Rawls Raegan , Tucker Jason D. , Blaeser Anthony , Lu Qi Long
Published: December 2022

Limb Girdle Muscular Dystrophy 2I (LGMDR9) is one of the most common LGMD characterized by defects in glycosylation of α-dystroglycan (matriglycan) resulting from mutations of Fukutin-related protein (FKRP). There is no effective therapy currently available. We recently demonstrated that ribitol supplement increases levels of matriglycan in cells in vitro and in FKRP-P448L (P448L) mutant mouse model through drinking water administration. To be clinically relevant, we have now conducted a dose-escalating efficacy study by gavage in P448L mutant mice. Six months of ribitol treatment daily significantly rescued functions of skeletal, respiratory, and cardiac muscles dose-dependently. This was associated with a dose dependent increase in matriglycan and improvement in muscle pathology with reductions in muscle degeneration, inflammatory infiltration and fibrosis. Importantly, ribitol significantly increased life span and muscle functions of the female animals receiving treatment from 10 months of age. The only observed side effect was gastrointestinal tract bloating with loose stool and this effect is also dose dependent. The results validate the mechanism that ribitol as a pre-substrate of glycosyltransferase is able to compensate for the decreased function of mutant FKRP with restoration of matriglycan expression and provide a guidance for future clinical trial design.