bluuebunny/crossref_metadata_2025 huggingface dataset:
BRAND PROTECTION FOR MSMES IN ENCOURAGING ECONOMIC GROWTH IN INDONESIA
Authors: Tribuana Robi Rendra , Lubis Riyani Fitri
Published: September 2024

This research seeks to analyze the significance of brand protection for Micro, Small, and Medium Enterprises (MSMEs) in encouraging economic growth in Indonesia. Through a normative juridical approach, this research identifies brand protection as the key to strengthening the position of MSMEs in a competitive market. By providing adequate brand protection, MSMEs can build reputation, increase competitiveness, and expand access to markets and financial resources. However, challenges such as a lack of understanding about brand protection, the complexity of the registration process, and high costs need to be overcome through educational approaches, process simplification, and incentives for MSMEs. Thus, brand protection will not only provide direct benefits for MSMEs but will also contribute to inclusive and sustainable economic growth in Indonesia.
PENGUATAN OTONOMI DAERAH DENGAN REKONSTRUKSI PEMBENTUKAN PERDA TENTANG PAJAK DAERAH DI SUMATERA UTARA
Authors: Siregar Mardona
Published: September 2024

Pembentukan otonomi daerah merupakan upaya untuk meningkatkan kesejahteraan rakyat. Misalnya Perda tersebut adalah Perda Nomor 5 Tahun 2011 Tentang Pajak Daerah di Kabupaten Padang Lawas, Perda Nomor 11 Tahun 2010 Tentang Pajak Daerah di Kabupaten Padang Lawas Utara. Di antara 20 Perda Pajak Daerah yang dibatalkan di Sumut, ada 4 (empat) Perda Pajak Daerah di kabupaten/kota mengalami permasalahan yang sama. Perda yang dibatalkan sama-sama mengenai Pajak Daerah pada tahun yang sama dan tahun terdekat. Pajak daerah ditetapkan dengan undang-undang yang pelaksanaannya di daerah diatur dengan Perda. Kenyataannya, banyak Perda yang telah dibentuk oleh DPRD dan Pemerintah Daerah dibatalkan oleh Pemerintah Pusat. Mengapa banyak Perda Tentang Pajak Daerah dibatalkan oleh Pemerintah Pusat di Sumut?. Jenis penelitian yang digunakan adalah penelitian normatif dengan pendekatan empiris.  penelitian ini digunakan untuk memperoleh data normatif dan empiris, agar tampak relevansi antara penelitian normatif dengan data empiris. Berdasarkan uraian disimpulkan banyaknya Perda Tentang Pajak Daerah yang dibatalkan oleh Pemerintah Pusat di Sumut tidak terlepas dari kenyataan bahwa Perda yang sudah dibentuk langsung dilaksanakan oleh daerah tanpa persetujuan terlebih dahulu dari pemerintah pusat, sehingga pengawasan terhadap Perda tersebut tidak dapat berjalan secara efektif. Otonomi daerah seluas-luasnya bukan berarti daerah bebas menentukan tanpa ada kontrol dari pemerintah pusat.
RESPONSE OF MICRO, SMALL AND MEDIUM ENTERPRISES (UMKM) FAST FOOD TO THE OBLIGATION OF HALAL CERTIFICATION IN BIMA TOWN INDONESIA
Authors: Amrin Amrin , Al Mumtahanah Al Mumtahanah , Fitriyah Mas'udatul
Published: September 2024

This study aims to find out how the Response of Micro, Small, and Medium Enterprises of Fast Food to the Obligation of Halal Certification in the City of Bima, West Nusa Tenggara Province. This uses a type of qualitative research descriptive with a sociological approach. As for collection techniques namely observation, interviews, and documentation. While technique processing data analysis using reduction, data presentation, and conclusion. The results of this study indicate that first, the response of UMKM  in fast food regarding the understanding of halal certification has partially been understood even though details have not been conveyed. Second, UMKM response to PPH Act indicates strongly agrees with the existence of halal certification required by regulations to obtain halal guarantees from a food product served. Third, the response of UMKM  to the benefits of labeling halal certification provides a good value because in the future UMKM  want halal certification to be able to bring in material profit values as well as benevolent values (spiritual). Therefore, it is hoped that the latest Law will be a solution to various kinds of emerging problems and obstacles faced by UMKM.
KEDUDUKAN SYIRKAH ABDAN PERSPEKTIF MAZHAB SYAFI’I
Authors: Putra Dedisyah
Published: September 2024

AbstrakImam Syafi’i yang bernama Muhammad bin Idris as-Syafi’i merupakan salah satu ulama ahlussunnah kenamaan yang mencetuskan salah satu dari empat mazhab yang diakui dalam Islam yang dinisbatkan kepada nama sang imam yaitu mazhab Syafi’i. Namun dalam beberapa persoalan hukum, imam syafi’i sering berseberangan dengan pandangan ulama mazhab yang lain bahkan dalam mazhab sendiri imam syafi’i dikenal memiliki dua pandangan hukum berbeda yang dikenal dengan qaul qadil dan qaul jadid termasuk pandangannya yang berbeda dengan ulama lain seperti mazhab hanafi, maliki dan hambali yang berkaitan dengan syirkah abdan. Penelitian ini merupakan kajian kepustakaan yang bersifat deskriptif dengan pendekatan kualitatif. Hasil dari penelitian menunjukkan bahwa imam syafi’i dalam mazhabnya Kedudukan syirkah abdan  menurut Imam Syafi'i dan pengikutnya. (mazhab Syafi’i) syirkah abdan adalah batil, dikarenakan tidak terdapatnya modal di dalamnya sedangkan dalam suatu usaha harus ada modal. Selain itu, juga terdapat unsur gharar di dalamnya karena setiap tenaga atau keahlian manusia berbeda-beda sehingga ditakutkan adanya salah satu pihak yang dirugikan oleh pihak lain, dengan memanfaatkan keahlian teman seperkongsiannya. Kata Kunci: Hukum, Mazhab Syafi’i, Syirkah Abdan AbstractImam Shafi'i named Muhammad bin Idris as-Syafi'i is one of the well-known ahlussunnah scholars who sparked one of the four recognized schools of thought in Islam which are attributed to the name of the priest, namely the Shafi'i school. However, in a number of legal matters, Imam Shafi'i is often at odds with the views of other madhabs. Even within his own school, Imam Shafi'i is known to have two different legal views, known as qaul qadil and qaul Jadid, including views that are different from other scholars, such as the Hanafi school of thought. , maliki and hambali related to syirkah abdan. This research is a descriptive literature study with a qualitative approach. The results of the study show that the position of syirkah abdan according to Imam Syafi'i and his followers is in his school of thought. (Syafi'i school) syirkah abdan is vanity, because there is no capital in it while in a business there must be capital. Apart from that, there is also an element of gharar in it because every human power or expertise is different so one is afraid that one party will be harmed by another party, by utilizing the expertise of their partners.Keywords: Law, Shafi'i School, Syirkah Abdan
URGENSI ETIKA DALAM KEABSAHAN JUAL BELI (STUDI KASUS DI PASAR RAYA SANGKUMPAL BONANG)
Authors: Lubis Ihsan Helmi , Faizin Mu'adil
Published: September 2024

Buying and selling transactions at Pasar Raya Sangkumpal Bonang are carried out with ethics that are not commendable by the seller to the prospective buyer so that the validity of the sale and purchase needs to be reviewed. The method used to solve the problem in this study is a type of field research with a case study approach to the ethics of the seller of Toko X Pasar Raya Sangkumpal Bonang Padangsidimpuan, the data sources in this study are primary and secondary data sources. Primary data sources consist of interviews with sellers and buyers. Meanwhile, secondary data sources refer to journals and books that are relevant to the researcher's discussion. Based on these problems, researchers will analyze using the theory of Islamic business ethics. based on the results of the study that the practice of transactions carried out by sellers and buyers is null and void because there is an element of coercion carried out by the seller.
JUAL BELI SUBSCRIBERS YOUTUBE PERSPEKTIF HUKUM ISLAM
Authors: SIRAIT ADI SYAHPUTRA , Tanjung Dhiauddin
Published: September 2024

This article aims to explain whether Subscribers and Viewers are part of the property and how the law of buying and selling is from the perspective of Islamic Law. The method used in this paper is normative empirical with a phenomenological approach. The technique used in collecting data in this article is by observing and tracing the buying and selling practices of viewers and subscribers in online buying and selling services. Then the data is analyzed using literature related to buying and selling (Fiqh Muamalah). The results of this study indicate that the sale and purchase of viewers and subscribers is the sale and purchase of tadlis which is prohibited in Islam because it contains elements of Gharar (uncertainty) both in the account sold by the seller because it is not owned or the benefits received by the buyer because it can decrease at any time. Meanwhile, viewer and subscriber buying and selling transactions that are permitted according to syara' law are carried out using aqad istisna' provided that the account is not for commercial use.
HALAL DAN HARAMNYA INVESTASI SAHAM BERBASIS SYARIAH DI PASAR MODAL
Authors: Qodir Abdul , Kurniawan Puji
Published: September 2024

The purpose of investing can be used to improve people's welfare, guarantee finances in old age and even more broadly to improve the state of the country's economy to achieve economic stability. In general, people still think that investing in stocks is difficult and difficult and requires large funds, conditions like this are due to a lack of knowledge and socialization about investing in Islamic stocks. This study aims to find out about the law of investing in Islamic stocks, from the halal and haram sides. research method used in the form of literature study. Library research in the face of various literature in accordance with the objectives and problems that will be and are being studied. The conclusion from this study is that the law of buying and selling stocks and stock exchanges in Islam as long as the transaction method is carried out according to sharia demands and the types of shares purchased from companies that carry out their business in a halal manner, then all transactions in the capital market including shares are halal.
ANALISIS TINAJUAN HUKUM TERHADAP PENUNDAAN PELAKSANAAN PEMBAGIAN HARTA WARISAN PADA MASYARAKAT DESA SAWAH KEC KAMPAR UTARA KAB KAMPAR
Authors: Putra Deri Eka
Published: September 2024

The purpose of this study, entitled "The tradition of implementing inheritance in the Muslim community of Sawah Kec Kampar Utara Kab Kampar according to Islamic law review," is to gain a better understanding of the practice of Islamic law in the distribution of inheritance property in the Muslim community of Sawah Kec Kampar Utara Village. This field research was conducted in Sawah Village, North Kampar District. Primary data from heirs who postpone the division of inheritance and secondary data from relevant public figures, books and articles. The study found that Islamic law requires immediate distribution of the estate left behind after the management of the remains, debts receivable, and will of the deceased is completed.
PENEGAKAN HUKUM DALAM PENERAPAN HUKUM PIDANA DALAM PENGGUNAAN PERSPEKTIF ILMIAH HUKUM PIDANA
Authors: Nuroini Indi
Published: September 2024

Penelitian ini bertujuan untuk mengetahui Tindakan yang bersifat Represif Edukatif dalam penegakan Hukum Pidana Ketenagakerjaan dalam perspektif ilmu hukum pidana. Penelitian ini bertujuan untuk menganalisis landasan filosofis dan yuridis, serta konsepsi – konsepsi yang bersifat ilmiah mengenai penerapan asas Represif Edukatif dalam penegakan hukum pidana dibidang ketenagakerjaan. Dibidang ketenagakerjaan terdapat beberapa ketentuan hukum pidana yang telah jelas dirumuskan sebagai suatu delik, yang mana delik-delik tersebut juga merupakan bagian dari obyek pengawasan pegawai pengawas ketenagakerjaan. Simpulan yang dihasilkan adalah Bentuk dan penerapan asas Represif Edukatif dalam penegakan hukum pidana dibidang ketenagakerjaan dengan langkah – langkah bentuk pemeriksaan sampai diterbitkan nota pemeriksaan dan Perpektif ilmu hukum pidana terhadap asas Represif Edukatif dalam penegakan hukum pidana dibidang ketenagakerjaan dengan ketentuan hukum pidana yang telah dirumuskan sebagai delikKata Kunci : Represif Edukatif, penegakan Hukum Pidana, Ketenagakerjaan dan hukum pidana.
SANKSI KEBIRI DALAM KONTEKS KEJAHATAN SEKSUAL PADA ANAK: PERSPEKTIF HUKUM ISLAM DAN TEORI KEADILAN JOHN RAWLS
Authors: Mustafid Mustafid , Sulastri Sulastri , Qurtubi Achmad Napis , Hosen Hosen
Published: September 2024

This research aims to explore the views of Islamic law on the use of castration punishment in cases of sexual crimes against children and then relate it to the theory of justice put forward by John Rawls. This type of research is library research with a normative approach. Analysis was carried out using a qualitative descriptive approach. The results of this research are that there are two conditions. First, when the victim is the same as the perpetrator, this is called Liwath Sodomy and is punishable by death. Second, when the victim is not of the same type as the perpetrator, Zina is condemned; the sanction is for those who are married to be stoned to death and for those who are not married to be bound 100 times. Islam does not recognize the punishment of castration, so the law is ta'zir, but this does not mean that castration can punish perpetrators of sexual crimes against children. Furthermore, when related to John Rawls's theory of justice, first, the principle of equal standing emphasizes the importance of providing equal opportunities to all individuals, including criminals, to improve their social position. Second, the principle of equitable differences requires that inequality in society is only acceptable if it benefits the most disadvantaged. In the context of castration, the question is whether the action benefits the victim or society. Therefore, Jonh Rawls's concept of justice indirectly does not recognize the punishment of castration for sexual crimes against children.
Indonesia's protection of Rohingya refugees and regional geopolitical principles
Authors: Muttaqin Entol Zaenal
Published: September 2024

As one of the main countries in the ASEAN regional organisation, Indonesia plays an important role in establishing peace and mutually beneficial relations. Even in the case of the mass exodus of Rohingya refugees, which is attracting attention because it is linked to humanitarian issues, many countries are reluctant to accept the arrival of these refugees who are considered stateless. Moreover, many countries are reluctant to accept the arrival of these refugees who are considered stateless, as Myanmar has revoked their citizenship and does not consider them to be citizens. One of the countries visited is Indonesia, and not just as a country seeking political asylum, but in this case Indonesia is obliged to pay attention, even though legally it has not signed the UN Convention on Refugees, particularly Indonesia's position as a large country within ASEAN. Therefore, this paper aims to answer several questions, namely: the format of Indonesia's policy towards Rohingya asylum seekers under humanitarian and human rights law, then the formula of Indonesia's role in resolving the Rohingya refugee conflict in Myanmar in the context of ASEAN's international relations, and the relevance of Indonesia's international policies and the 1951 Geneva Refugee Convention in protecting refugees across Indonesian borders. The method used is a legal empirical method using primary legal source data and analysed qualitatively. The paper concludes that Indonesia needs to pay attention to the international legal framework regarding refugees, that Indonesia's potential in resolving the Rohingya conflict is very strategic because it is politically active, and finally that the relevance of the 1951 Geneva Convention and Indonesia's foreign policy is very compatible because the convention aims to protect refugees.
The Influence of Advertising, Brand Image, and Product Quality on Purchase Decisions of Skincare Beauty Products in Medan
Authors: Angela Callista Leonardi  , Alfonsius Alfonsius
Published: September 2024

As time goes by, cosmetics have become one of the most important needs of women. In everyday life, women cannot be separated from cosmetics from morning to night, both face and body. In this current era, beauty products are increasingly diverse, and competition in the body care and cosmetics industry is fierce. At the same time, beauty and cosmetic products have undergone many changes, with various innovations that meet consumer needs and desires. This research aims to evaluate the influence of advertising, brand image, and product quality on purchasing decisions for skincare beauty products. The sample in this study consisted of 75 respondents, and the data analysis technique used was multiple linear regression. The research results showed that advertising, brand image, and product quality influence purchasing decisions for skincare beauty products. Partially, it showed that advertising has a significant influence on purchasing decisions, brand image has an important influence on purchasing decisions, and product quality influences purchasing decisions for skincare beauty products.
Personal Data Protection in Private Sector Electronic Systems for Businesses: Indonesia vs. South Korea
Authors: Silviani Ninne Zahara , Shahrullah Rina Shahriyani , Atmaja Vanessa Riarta , Hyun Park Ji
Published: September 2024

This paper explores the various practices surrounding the legal framework for protecting personal data in the context of private electronic systems used by commercial companies. The research's main focus is the ambiguity of the goals of Indonesia's Electronic System providers and how they may adopt better practices to enhance data protection within Electronic System Providers, so this extensive examination also includes a thorough comparison of the personal data protection laws in South Korea and Indonesia. This investigation aims to carefully define, evaluate, and harmonize the two countries' unique legal systems. This study uses a normative legal research framework with a Teleological and Legal Protection approach as its research technique. Additionally, it uses the comparative law method to clarify, outline, and examine the specifics of the personal data protection laws that are now in force in Indonesia and South Korea. The results of this research go beyond identifying problems; they are expected to produce a thorough understanding of the complexities surrounding personal data security in the context of electronic commerce. These discoveries are well-positioned to be the foundation for upcoming regulatory improvements, eventually encouraging more potent and reliable data protection procedures in both nations.
Electronic Evidence in The Healthy Justice System: Reimagined
Authors: Komalasari Rita , Mustafa Cecep
Published: September 2024

This study addresses one of the critical difficulties related to the admissibility of electronic evidence. This essay examines the reliability of electronic evidence in foreign criminal and civil justice systems and offers suggestions for revising the reliability of electronic evidence in Indonesian court processes. In terms of the legitimacy of electronic evidence in the criminal justice system, the method adopted is the present comparative policy approach in various nations. The paper presents the concept of a rapid check mechanism for verifying electronic evidence, which swiftly advances the settlement of criminal and civil cases.
O desenvolvimento das notae unitatis
Authors: Gonzaga Waldecir , Belem Doaldo Ferreira
Published: September 2024

The letters to the Galatians and to the Ephesians, respectively, one proto-Pauline and one deutero-Pauline, have been the subject of several studies due to their contents and forms, especially in the field of freedom and the universality of salvation. These are two letters from the Pauline epistolary that are well accepted by the various Christian traditions: by Catholics, Orthodox and Protestants. This article aims to analyze the theme of ecumenism based on two passages taken from these letters, Gal 3:26-29 and Eph 4:1-6, which address the universality of divine filiation through baptism and of the Gospel of Christ, proclaimed to all without any distinction, which should be a cause of unity and not division, especially among those who accept Jesus Christ as Lord and Savior. To achieve this objective, this article presents data on the letters, considering text and context, and performs an exegesis of the two passages indicated here (Gal 3:26-29 and Eph 4:1-6). Both promote dialogue and openness to charting paths together, whether through baptism or the Gospel. They open doors and windows, build bridges and not walls, broaden horizons and indicate paths of dialogue and respect between the sons and daughters of God, and between them and other believers and non-believers, in a common cooperation in the promotion of human life, for the sake of our common home, the Kingdom. They are like scores indicating the musical notes to be played harmoniously by the symphony orchestra, with its many and varied instruments.
A double whammy of bullous pyoderma gangrenosum and deep vein thrombosis following COVID-19 infection
Authors: Joy Nirma , Sobhanakumari K. , Abraham Amitha , Mathews Henry , George Edwin
Published: September 2024

Bullous pyoderma gangrenosum (PG) is a rare variant presenting with hemorrhagic bulla and is usually associated with hematological malignancies. COVID-19 infection has various clinical manifestations, with one-fourth of patients developing deep vein thrombosis (DVT). There are a few reports of PG following COVID-19 infection or vaccination. We report a case of bullous PG, and skin lesions worsened due to concurrent DVT and COVID-19 infection, prolonging its healing time and physical disability.
Long-term observation of refractional changes in schoolchildren with cicatricial phase of retinopathy of prematurity
Authors:   Burnasyan Federal Medical Biophysical Center, Moscow, Russian Federation, Rychkova S.I. ,   Kharkevich Institute for Information Transmission Problems, Moscow, Russian Federation,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Laver A.B. ,   Burnasyan Federal Medical Biophysical Center, Moscow, Russian Federation, Kurysheva N.I. ,   Burnasyan Federal Medical Biophysical Center, Moscow, Russian Federation
Published: September 2024

Original article Long-term observation of refractional changes in schoolchildren with cicatricial phase of retinopathy of prematurity S.I. Rychkova, A.B. Laver, N.I. Kurysheva Burnasyan Federal Medical Biophysical Center, Moscow, Russian Federation Kharkevich Institute for Information Transmission Problems, Moscow, Russian Federation Pirogov Russian National Research Medical University, Moscow, Russian Federation Purpose. To evaluate dynamics of refractional changes in schoolchildren with the cicatricial phase of retinopathy of prematurity over a ten-year follow-up period. Material and methods. A retrospective analysis of refractional changes dynamics over 10 years was performed in a group of 18 schoolchildren (36 eyes) with a scar phase (PH) and a control group including 24 schoolchildren (48 eyes) with congenital myopia. All children studied in a special school with adapted conditions for children with ophthalmopathology. Results. Refractive indices at the beginning of the follow-up (at 7 years) in both groups were statistically comparable (p=0.51). According to the correlation analysis, the value of myopic refraction according to the spheroequivalent significantly increased with age in both groups (r=0.99, p<0.001). At the same time, the increase in myopic refraction over a ten-year follow-up period was more significant (p=0.005) in the group of children with congenital myopia (on average 2.0±0.2 D) than in the group of children with PH (on average 1.1±0.2 D). As a result of the functional treatment, the increase in visual acuity in the group of children with congenital myopia (on average by 0.14±0.02) was more significant (p<0.001) than in the group of children with PH (on average by 0.02±0.01). Conclusion. The results of our work demonstrate the need for further investigation of the features of refraction and visual functions of patients with the scar phase of PH and an individual approach to choosing the optimal correction of the identified disorders using modern achievements in this field. Key words: retinopathy of prematurity, congenital myopia, optical correction
IgG4-related disease involving the tissues of the orbit in a five-year-old child
Authors:   Moscow Regional Research Institute of Childhood, Mytishchi, Moscow Region, Russian Federation, Kotova Y.V. , Grishina E.E. ,   M.F. Vladimirsky Moscow Regional Research Institute, Moscow, Russian Federation, Kondratieva E.I. ,   Moscow Regional Research Institute of Childhood, Mytishchi, Moscow Region, Russian Federation, Fokanova G.I. ,   Moscow Regional Research Institute of Childhood, Mytishchi, Moscow Region, Russian Federation, Tarabanko I.M. ,   M.F. Vladimirsky Moscow Regional Research Institute, Moscow, Russian Federation
Published: September 2024

Case study IgG4-related disease involving the tissues of the orbit in a five-year-old child Yu.V. Kotova, E.E. Grishina, E.I. Kondratieva, G.I. Fokanova, I.M. Tarabanko Moscow Regional Research Institute of Childhood, Mytishchi, Moscow Region, Russian Federation M.F. Vladimirsky Moscow Regional Research Institute, Moscow, Russian Federation Purpose. To demonstrate a rare clinical case of IgG4-related disease in the practice of a rheumatologist, a pediatrician and an ophthalmologist. Material and methods. A 5-year-old child had a lesion in the left orbit, manifested by left-sided exophthalmos, medial displacement of the left eye, and limited outward eye mobility. He underwent an orbitotomy with histological and immunohistochemical examination of the biopsy specimen in the ophthalmology department of M.F. Vladimirsky Moscow Regional Research Institute. A diagnosis of IgG4-related disease involving the left orbital tissue was made. Results. In the rheumatology department of the Moscow Regional Research Clinical Institute of Childhood, the boy received pulse therapy with glucocorticoids. When trying to reduce the dose of glucocorticoids, exophthalmos and swelling of the eyelids on the left increased again. Cyclophosphamide therapy was ineffective. In addition to oral Prednisolone, Rituximab, a drug from the group of synthetic chimeric monoclonal antibodies, was prescribed. A stabilization of the process in the left orbit and an improvement in the general condition of the child ocurred. The duration of remission is 2 years. Discussion. IgG4-related disease is characterized by lymphoplasmacytic infiltration of tissues with a predominance of IgG4-positive cells and subsequent formation of fibrosis. Ophthalmological manifestations of IgG4-related disease are most often characterized by damage to the tissues of the orbit and lacrimal gland. Usually develops in middle-aged people; it is rare in pediatric practice. Conclusion. Patients with IgG4-related disease can be encountered in the practice of a rheumatologist, pediatrician and ophthalmologist. If diagnosis and treatment are not urgent, the disease is prone to progression, which leads to disability of the patient. The main treatment method is long-term use of glucocorticoids. In case of steroid resistance or steroid dependence, early use of immunosuppressive drugs or monoclonal antibodies could be considered. Key words: immunoglobulin G4-related disease, autoimmune orbital myositis, pediatric rheumatology, immunosuppressive therapy
A clinical case of staged treatment in a child with anisometropic amblyopia and hyperopia combined with divergent strabismus
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation, Kulikova I.L. ,   Postgraduate Doctors’ Training Institute, Cheboksary, Russian Federation, Aleksandrova K.A. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation, Pikusova S.M. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation, Kuzmina A.V. ,   Postgraduate Doctors’ Training Institute, Cheboksary, Russian Federation
Published: September 2024

Case study A clinical case of staged treatment in a child with anisometropic amblyopia and hyperopia combined with divergent strabismus I.L. Kulikova, K.A. Aleksandrova, S.M. Pikusova, A.V. Kuzmina S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation Postgraduate Doctors’ Training Institute, Cheboksary, Russian Federation A clinical case of a child with anisometropic amblyopia, hypermetropia and divergent strabismus is considered. Clinical and functional results of staged treatment, including refractive laser surgery and surgical correction of strabismus, are presented. This treatment makes it possible to create optimal conditions for the more effective treatment of amblyopia and preservation of orthotropia in children with anisometropic amblyopia, hypermetropia and divergent strabismus. Key words: amblyopia, hyperopia, exotropia, FS-LASIK
ПРОЕКТНОЕ УПРАВЛЕНИЕ В РЕГИОНЕ В ЭПОХУ ЦИФРОВОЙ ТРАНСФОРМАЦИИ
Authors: Приходченко О.С. , Агеева П.А. , Ерпулева Д.А.
Published: September 2024

В данной статье рассматривается проектное управление в условиях цифровой трансформации, на примере Курской области. Были проанализированы предварительные результаты региональных проектов, реализуемых в рамках национального проекта «Цифровая экономика». Цель исследования – выявить особенности и тенденции проектного управлении на региональном уровне в условиях цифровой трансформации. Методологической базой исследования послужили традиционные для теоретико-прикладных исследований методы: обобщение имеющейся информации, методы вертикального и графического анализа данных, статистический анализ, синтез, сопоставление.
СОВЕРШЕНСТВОВАНИЕ ТЕОРЕТИЧЕСКИХ ПОЛОЖЕНИЙ ПОСТРОЕНИЯ МОДЕЛЕЙ ЭФФЕКТИВНОГО ХОЗЯЙСТВОВАНИЯ В ПРОДУКТОВЫХ ПОДКОМПЛЕКСАХ
Authors: Агнаева И.Ю.
Published: September 2024

Моделирование процесса хозяйствования субъектов продуктовых подкомплексов АПК сегодня сталкивается с двумя основными проблемами: недостаточностью и достоверностью данных. Решение обозначенной проблемы возможно через совершенствование теоретических положений построения моделей эффективного хозяйствования в продуктовых подкомплексах. В рамках исследования были получены результаты сформулированные в статье в форме (1) уточнения трактовок понятий «эффективность» (авторское: соотношение затрат и полученного результата, с учётом условия оптимальности, учитывающего ряд неэкономических факторов) и «подкомплекс» (авторское: подсистема АПК, выделенная по продуктовому принципу и включающая в себя всех субъектов хозяйствования обеспечивающих функционирование подкомплекса, а так же имеет институциональные особенности регулирования и функционирования); (2) уточнения сущности моделей эффективного хозяйствования в основных продуктовых подкомплексах АПК; (3) систематизации теоретико-методических положений построения моделей эффективного хозяйствования на основе критериев оценки.
ОСНОВНЫЕ ПРИНЦИПЫ ПОСТРОЕНИЯ ОРГАНИЗАЦИОННО-АНАЛИТИЧЕСКОЙ МОДЕЛИ РАЗРАБОТКИ НОВОГО СТАНДАРТА
Authors: Крылов К.И.
Published: September 2024

В статье рассматриваются принципы и подходы к построению организационно-аналитической модели нового стандарта, основанной на интересах заинтересованных сторон – потребителя и изготовителя. Предлагается использовать такой подход, который позволяет установить взаимосвязь между измеряемыми показателями качества продукции и ее функциями, необходимыми потребителю.
ПРАКТИЧЕСКИЕ АСПЕКТЫ ПРИМЕНЕНИЯ ФСБУ 6/2020 ПРИ ПЕРЕОЦЕНКЕ ОСНОВНЫХ СРЕДСТВ
Authors: Меньщикова В.И. , Кириченко Е.А.
Published: September 2024

Реформирование системы бухгалтерского учета в РФ предопределяет необходимость понимания бухгалтерами, особенно начинающими, последствий применения новых стандартов бухгалтерского учета основных средств. В работе раскрыт порядок применения ФСБУ 6/2020 при проведении переоценки основных средств организации. Целью статьи является исследование влияния способов переоценки основных средств на отражение хозяйственных операций на счетах бухгалтерского учета, а также на формирование показателей бухгалтерской отчетности организации в соответствии с применением положений ФСБУ 6/2020. На практическом примере определено, как изменяются суммы годовых амортизационных отчислений, накопленной амортизации, остаточной стоимости основных средств, размера справедливой стоимости, а также результаты дооценки объекта основных средств при разных способах переоценки.
УПРАВЛЕНЧЕСКИЙ ТРУД: ПОНЯТИЕ И ОСОБЕННОСТИ НОРМИРОВАНИЯ
Authors: Мингалева Ж.А. , Оборина А.В.
Published: September 2024

В статье приведено описание управленческого труда, содержание трудовых функций управленческого персонала, которые необходимо учитывать при формировании системы нормирования труда управленческого персонала. Особую важность это приобретает в современных условиях при организации управленческого труда в инновационных коллективах, на высокотехнологичных предприятиях, отличающихся особыми требованиями к управлению деятельностью. Управленческий труд – категория, обладающего высокой эффективностью и влиянием на показатели деятельности предприятия, но при этом нетиповая категория с точки зрения организации системы нормирования. В статье приведены характерные черты управленческого труда и его отличительные характеристики, которые затрудняют применение для его нормирования стандартных и унифицированных инструментов и методик, используемых для производственного персонала. Исследование проведено в рамках базовой части государственного задания Министерства науки и высшего образования Российской Федерации Пермскому национальному исследовательскому политехническому университету (тема № FSNM-2020-0026).
АНАЛИЗ СОВРЕМЕННОГО СОСТОЯНИЯ ФОНДОВОГО РЫНКА РОССИИ В УСЛОВИЯХ ЭКОНОМИЧЕСКОГО КРИЗИСА (В ПЕРИОД РАСПРОСТРАНЕНИЯ COVID-19)
Authors: Самсонов Е.А.
Published: September 2024

Актуальность темы обусловлена настоящим кризисным положением России, что обусловлено зависимостью экономики РФ от цены нефти, мировой экономики и политики в целом. В статье приведены данные и показатели, характеризующие особенности фондового рынка. В статье отмечается, что происходящие изменения в мировой экономике в кризисный и посткризисный период оказывают свое влияние на фондовый рынок России. Наиболее актуальной задачей является решение проблемы развития и эффективного использования торговых систем на российских фондовых биржах. Проведен анализ происходящих процессов за период с 2017 по 2021 г. с использованием показателей, рассчитанных с помощью эконометрических методов. Выявлена тенденция развития российского рынка, заключающаяся в повышении интенсивности торгов и в восстановлении их объемов после кризиса.
МЕТОДИЧЕСКИЕ АСПЕКТЫ ФОРМИРОВАНИЯ СТРУКТУРЫ ОТЧЁТА О ДВИЖЕНИИ ДЕНЕЖНЫХ СРЕДСТВ
Authors: Котельникова Н.В.
Published: September 2024

В статье представлены рекомендации по раскрытию информации в отчёте о движении денежных средств, составленного прямым методом. Общую структуру отчёта предлагается дополнить показателями: денежные потоки на бизнес или денежные потоки до расчёта с владельцами капитала; денежные потоки, приходящиеся на владельцев собственного капитала. Дополнение повысит релевантность отчёта для стейкхолдеров оценивающих бизнес, так как они смогут без дополнительных расчётов использовать данные показатели для оценки бизнеса доходным или сравнительным методом. Операционные поступления и платежи предлагается разделить на денежные средства, полученные/выплаченные в качестве: предоплаты на конец периода; оплаты за проданные/приобретённые товары и услуги в периоде; погашение задолженности. Анализ такой детализация позволит своевременно выявить признаки финансовой пирамиды бизнеса, основанной на постоянном увеличении клиентской предоплаты, которая используется для погашения кредиторской задолженности, кредитов, оплаты текущих расходов. Для понимания стейкхолдерами направления и объёма инвестиций бизнеса, инвестиционные денежные потоки предлагается представлять в разрезе инвестиций в реальные и финансовые активы, детализируя последние на: инвестиции в компании группы, финансирование обособленных подразделений, кредитование собственников бизнеса; торговые операции на финансовом рынке. В финансовых потоках следует расчёты с владельцами заёмного и собственного капитала разделять по разным разделам. Предлагаемые изменения в представлении денежных потоков позволяют повысить аналитичность отчёта о движении денежных средств, так как сократят время стейкхолдеров на получение релевантной информации.
The Development and Innovation of Religious, Secular, and Archaeological Tourism in Saudi Arabia
Authors: Al Qurtuby Sumanto
Published: September 2024

Various fundamental changes have occurred in Saudi Arabia in recent decades. One sector that has experienced robust change and innovation in present-day Saudi Arabia is tourism. This article discusses the contemporary shift in Saudi Arabia’s religious, secular, and archaeological tourism sectors, as well as the history and development of Saudi tourism, in order to understand the factors, motives, logic, and driving forces that contribute to this change. The article argues that the development and innovation in Saudi tourism today are not merely driven by economic motivations, but are also propelled by governmental aspirations to create a new identity for Saudi Arabia: a global tourist destination, a modern country equipped with the latest technology, a pluralistic and tolerant society that welcomes foreign cultures, and a moderate nation that promotes religious moderation and discourages militancy and conservatism.
Catalytic function of zinc finger proteins against amyloid- amyloidogenesis
Authors: Park Seongmin , Hwang Yunha , Lin Yuxi , Kwak Jimin , Nam Eunju , Han Jiyeon , Kang Hyun Goo , Park Jiyong , Lee Young-Ho , Lee Seung Jae , Lim Mi Hee
Published: September 2024

Zinc finger (ZF) proteins are integral to neurological processes by mediating biomolecular interactions and regulating gene expression. Despite their implication in neurodegenerative diseases, the precise contribution of ZF proteins to disease pathology remains unclear. Here we show the direct binding of the ZF protein PARIS(ZF2–4) with amyloid-beta (Abeta) as well as its catalytic function in reprofiling Abeta aggregation and cytotoxicity, a key contributor to Alzheimer’s disease. The complex formation between PARIS(ZF2–4) and Abeta promotes the amorphous aggregation of Abeta, which reduces its interaction with cell membranes and prevents the formation of toxic oligomers and fibrils, thus alleviating A-induced cytotoxicity. Through sequence-based reactivity and mechanistic analyses employing fragments and variants, we identify structural motifs critical for PARIS(ZF2–4)’s function. These findings demonstrate a novel modulative role of ZF proteins in Abeta amyloidogenesis, highlighting a sequence–reactivity relationship that offers insights into potential therapeutic avenues for neurodegenerative disorders.
Ultrafast Dynamics in Spatially Confined Photoisomerization: Accelerated Simulations through Machine Learning Models
Authors: Xu Weijia , Xu Haoyang , Zhu Meifang , Wen Jin
Published: September 2024

This study sheds light on the exploration of photoresponsive host-guest systems, highlighting the intricate interplay between confined spaces and photosensitive guest molecules. Conducting nonadiabatic molecular dynamics (NAMD) simulations based on electronic structure calculations for such large systems remains a formidable challenge. Leveraging machine learning (ML) as an accelerator for NAMD simulations, we analytically constructed excited-state potential energy surfaces along relevant collective variables to investigate photoisomerization processes efficiently. Combining the quantum mechanics/molecular mechanics (QM/MM) methodology with ML-based NAMD simulations, we elucidated reaction pathways and identified key degrees of freedom as reaction coordinates leading to conical intersections. A machine learning-based nonadiabatic dynamics model has been developed to compare the excited-state dynamics of the guest molecule, benzopyran in both the gas phase against its behavior within the confined space of cucurbit[5]uril. This comparative analysis is designed to expose the influence of the environment on the photoisomerization rate of the guest molecule. The results underscore the effectiveness of ML models in simulating trajectory evolution cost-effectively. This research offers a practical approach to accelerate NAMD simulations in large-scale systems of photochemical reactions, with potential applications in other host-guest complex systems.
Understanding the Granular Behavior of a Unidirectional Molecular Motor Through Combined DFT-Stochastic Simulation Studies
Authors: Bajpai Priyam , thulasiram shrivatsa , vanka kumar
Published: September 2024

Developing autonomous, chemically fueled, unidirectional molecular motors is currently a very vibrant area of research. Possibly the most exciting recent advancement in this field was the report of a 360° rotatory chiral catalyst-driven motor using the 1-phenylpyrrole 2, 2′-dicarboxylic acid motor molecule (Leigh and coworkers, direct reference). This molecule was seen to undergo complete rotation in one direction along a C-N bond with the aid of double kinetic gating provided by (i) a chiral fuel-waste reaction and (ii) a chiral catalyst aided hydration reaction. While this is a remarkable development, it is important to note that the final step of the rotation process in this system could not be tracked by experiment, and was hypothesized based on the assumed ease of rotation along the C-N bond at that step. Since the rotor also has the option of reverting back in a reverse rotation step from this point, it is important to investigate carefully all the possibilities of movement of the system and determine the correctness of the complete rotation, as well as the efficacy of such motion, along with a granular understanding the nature and behavior of the system at every step of the process. Such a desirable study is only possible through carefully conducted and validated computational studies. This is the motivation of the current work. We have employed a two-pronged approach, employing (i) full quantum chemical studies with density functional theory (DFT) to elucidate the proper reaction mechanism for every step and obtain information about the thermodynamics and the kinetics of the processes, as well as (ii) exact stochastic simulations with the Gillespie algorithm, with the information obtained. We have first employed this approach on an analogue of the actual motor system (which was also reported by Leigh and co-workers in the same study), and properly validated our computational results with the experimental results obtained for this analogue. Subsequently, we have employed our validated approach to the actual motor system, and obtained interesting results that (i) show that the system indeed does behave like a molecular motor by rotating through 360° in a unidirectional fashion while the fuel exists, but (ii) it does so with poor efficiency, not utilizing all the energy of the fuel-waste reaction to do so. This work, therefore, provides important insights into the nature and behavior of such systems, which can lead to the development of more improved autonomous, unidirectional molecular motors in the near future.
Protocols for metallo- and serine-β-lactamase free energy predictions: insights from cross-class inhibitors
Authors: Güven Jonna Jasmin , Hanževački Marko , Kalita Papu , Mulholland Adrian , Mey Antonia
Published: September 2024

While relative binding free energy (RBFE) calculations using alchemical methods are routinely carried out for many pharmaceutically relevant protein targets, challenges remain. For example, open-source tools do not support the easy setup and simulation of metalloproteins, particularly when ligands directly coordinate to the metal site. Here, we evaluate the performance of RBFE methods for KPC-2, a serine-β-lactamase (SBL), and two non-bonded metal parameter setups for VIM-2, a metallo-β-lactamase (MBL) with two active site zinc ions. We tested two different ways of modeling the ligand-zinc interactions. First, a restraint-based approach, in which FF14SB zinc parameters are combined with harmonic restraints between the zincs and their coordinating residues. The second approach uses an upgraded Amber force field (UAFF) for zinc-metalloproteins with adjusted partial charges and non-bonded terms of zinc-coordinating residues. Molecular mechanics (MM) and quantum mechanics/molecular mechanics (QM/MM) simulations show that the crystallographically observed zinc coordination is not retained in MM simulations with either zinc parameter set for a series of known phosphonic acid-based inhibitors bound to VIM-2. These phosphonic acid-based inhibitors exhibit known cross-class affinity for SBLs and MBLs and serve as a benchmark for RBFE calculations for VIM-2, after validation with KPC-2. The KPC-2 free energy of binding estimates are within expected literature accuracies for the lig- and series with a mean absolute error of 0.43 (0.25, 0.66) kcal/mol and a Pearson’s correlation coefficient of 0.93 (0.86, 0.98). For VIM-2, the UAFF approach has improved correlation from 0.48 (−0.02, 0.86) to 0.66 (−0.09, 0.94), compared to the restraint approach. The presented strategies for handling ligands coordinating to metal sites highlight that simple metal parameter models can provide some predictive free energy estimate for metalloprotein–ligand systems, but leave room for improvement in their ease of use, modeling of coordination sites, and as a result, their accuracy.
Analytical Data Review on an Artificial Intelligence Platform for Doping Control in Horse Racing
Authors: Lai Chun Sing , Wong April S. Y. , Wong Kin-Sing , Wan Terence S. M. , Ho Emmie N. M.
Published: September 2024

In the screening of prohibited substances (PS) in horse biological samples with Gas Chromatography/Mass Spectrometry (GC/MS) and Liquid Chromatography/Mass Spectrometry (LC/MS) for doping control, enormous number of chromatograms are generated. Reviewing these chromatograms to identify suspicious findings requires extensive manual effort. Recent advancement in Artificial Intelligence (AI) enables its use to classify images into different categories. This can potentially be utilised to perform first-line analysis of chromatograms, which are usually displayed as images, by classifying them into "positive" (POS) or "negative" (NEG) in respect of the presence of PS. This study explores the feasibility of using AI to perform initial chromatogram analysis, aiming to improve the efficiency and accuracy of data vetting. A predictive model was developed using the image recognition tool in "Alteryx Designer", a data analytic software, to analyse chromatograms generated from LC/MS analysis of horse urine. The model was developed by training with over 6000 chromatograms that had manually been classified as "POS" or "NEG". To evaluate the model’s accuracy, around 700 manually-classified chromatograms were analysed by the model and the prediction accuracy was over 90 %. The model was applied to two of our in-house screening methods each covering over 300 drug targets. It was shown that the model can identify "SUS"/ "POS" and "NEG" chromatograms with high accuracy with no false negative classification. There are two major challenges in applying the developed model to perform first-line analysis in regular testing, with the first being the analysis time. With the existing Alteryx workflow, analysing one batch of samples from one of our in-house screening methods with a standard office PC requires 3-5 hours. The second challenge is the inflexibility of data extraction workflow. The workflow only works on analytical data generated from specific instruments and software which poses challenges to its implementation in regular testing which involves large variety of instruments and processing software.