bluuebunny/crossref_metadata_2025 huggingface dataset:
التعليل الصوتي للظواهر الصرفية
Authors: Al-Madany Eman
Published: June 2021

إن علم الأصوات علم يتداخل مع علوم اللغة عامة، ولكنه يتلازم وعلم الصرف إذ إن كثيراً من الظواهر الصرفية لا يمكن تفسيرها وتعليلها من دون الاستعانة بالدراسات الصوتية الأصلية. ويحاول هذا البحث تأصيل تضافر علْمَي الصوتي والصرف وذلك من خلال كتاب الخصائص لابن جني "392"، فقد كان لجهوده أثر كبير في التوجيه النحوي والصرفي فقد أسّس أصولاً صوتية، ووضع مصطلحات دقيقة ونظريات صوتية لا تزال تؤتي ثمرها إلى وقتنا.

وكان تعليله الصرفي الدقيق لظواهر الإبدال والإعلال والإدغام والعدول والاشتقاق مستقى من أصوات الحروف وتماثلها وخفّتها وثقلها. وقد أصَّل بفكره الثاقب لعلم الأصوات الصرفي بما ساقه من أمثلة وشواهد كثيرة جداً، أكّد من خلالها أنَّ الدراسات اللغوية من صرف ونحو تستند إلى علم الأصوات لفهم مكنوناتها وتعليل أسبابها، وأن التغير الصوتي له أكبر الأثر في التغيّر الدلالي المعنوي، لذلك فإن على الباحث إتقان علم الصوت ومن ثمّ يتجه إلى بقية علوم اللغة، وهذا ما يتبعه الدرس اللساني والصوتي الحديث.
آراكون والثقافة العربية الأندلسية
Authors: Mnite Layla
Published: June 2021

إن مسألة تأثير الشعر العربي الأندلسي، في الشعر الأوربي الحديث، من المسائل التي شغلت وما زالت تشغل الكثير من الباحثين قديماً وحديثاً، ذلك أن ظهور موضوعات عديدة جديدة، تضاف كل يوم تؤكد هذا التأثير، ولنثبت ذلك، سنتناول في دراستنا، تأثر الشاعر لويس آراغون في ديوانه " مجنون إلسا " تأثرا واضحاً في الأدب الأندلسي ونثبتُ حقيقة هذا التأثر. إذ يظهر هذا التأثر واضحاً في الرموز الشعرية التي وظفها الشاعر في التعبير عن مدلولاته الشعرية والمعنى الشعري.
اللغةُ العربيةُ وصراعُ اللغاتِ وتحدياتُ الهُويّةِ الثقافية
Authors: Jasim Thair H.
Published: June 2021

للغةِ العربيةِ خصوصيةٌ تميّزُها من سائرِ لغاتِ الأمم ، فهيَ لغةُ القرآنِ الكريم ، التي ارتبطت به ارتباطا وثيقا ، { إنّا أنزلناهُ قُرآنًا عربيًّا لعلّكمْ تعقِلون} (يوسف : 2) ، والتي ما تزالُ تُستعمَلُ بأصواتِها وكلماتِها وقواعدِها نفسِها حتى يومِنا هذا ، وكانت بجدارةٍ لغةَ الآدابِ والعلومِ والفنونِ . وترتبطُ كلُّ لغةٍ ارتباطاً تكوينياً وثيقاً بالبناءِ الحضاريِّ لأمتِها، وتُعدُّ عنواناً لشخصيتِها وهُويتِها, وأداةً للتعبيرِ عنِ الأفكارِ والمشاعر, وهيَ وسيلةُ التفاهمِ والتعلمِ والتطورِ وتناقلِ الخبرات. واللغةُ هيَ التي تحوّلُ الأفرادَ من جماعةٍ بشريةٍ إلى مجموعةٍ ثقافيةٍ مترابطة ، لأنّها تعملُ على تماسكِ البناءِ الاجتماعي ، وترابطِ أبناءِ الأمةِ الواحدةِ في البعدين : المكانيِّ الذي يتمثّلُ في انتشارِهم في الأمكنةِ المتباعدةِ ، والزمانيِّ الذي يتمثّلُ في تواصلِ الأجيالِ اللاحقةِ مع الأجيالِ السابقة .

واللغةُ العربيةُ تواجهُ اليومَ، وغداً أيضاً، تحدّياً حقيقياً ضارياً، يفرضُ عليها التعاملَ معهُ بذكاءٍ وفطنة ، والتحدّي الأكبرُ الذي سيواجهُ اللغةَ العربية في المستقبلِ ، هوَ المحافظةُ على خصوصياتِها وضمانُ استمرارِها وإشعاعِها، وحمايةُ المكوّناتِ والمقوّماتِ والقيَمِ التي تشكّلُ العناصرَ الجوهريةَ للكيانِ العربيِّ الإسلاميِّ الكبير . وذلك يستدعي الاهتمامَ باللغةِ العربيةِ تعلّما وتعليماً واتقاناً ، والعملَ الجادَّ على نشرِها في كلِّ المجالاتِ وعلى كلِّ المستويات ، ومعالجةَ مشكلاتِها في عصرِ العولمة ؛ وذلك ليسَ حاجةً شرعيةً فحسبْ ولكن ضرورةٌ ثقافيةٌ وحضارية .
المشاركة الاجتماعية في قضايا التنمية وتعزيز الهوية الوطنية لدي الشباب الجامعي
Authors: Al-Mutawa Ayesha Abdulla Ismail , Al-Othman Hussein Muhammed
Published: June 2021

انطلاقاً من الاهتمام الدولي والإقليمي والوطني والمحلي بفئة الشباب ، واعتماد  الامم المتحدة يوم12أغسطس يوماً دولياً للشباب يحتفل به سنوياً بدأ من عام 2000 ، سعت الدراسة الحالية نحو التعرف علي أهمية المشاركة الاجتماعية في قضايا التنمية ودورها في تعزيز الهوية الوطنية لدي الشباب الجامعي بالمجتمع الاماراتي ، واستهدفت الدراسة تحديد العلاقة بين بعض المتغيرات الديمجرافية والمشاركة الاجتماعية في قضايا التنمية لتعزيز الهوية الوطنية لدي الشباب الجامعي ، وذلك عن طريق اختبار فرضياتها الرئيسية المتضمنة من المتوقع وجود علاقة ذات دلالة احصائية بين بعض المتغيرات الديمجرافية للدراسة والمشاركة الاجتماعية في قضايا التنمية لتعزيز الهوية الوطنية لدي الشباب الجامعي ، ومن المتوقع وجود علاقة ذات دلالة إحصائية بين المشاركة الاجتماعية وتعزيز الهوية الوطنية لدي الشباب الجامعي، وتم استخدام منهج المسح الاجتماعي بالعينة العشوائية البسيطة وتضمنت عينة الدراسة (286) مفردة ، وتم استخدام استبانة من إعداد الباحثة ، وذلك للتوصل إلي نتائج الدراسة وتحليلها ، وقد أسفرت نتائج الدراسة إلي صحة فرضياتها ، كما كشفت النتائج  أن عملية المشاركة الاجتماعية في قضايا التنمية  تعزز من فرص الهوية الوطنية لدي الشباب الجامعي ، ولن تتحقق المشاركة في الأنشطة التنموية بالمجتمع إلا من خلال تحسين الأداء الاجتماعي للشباب ، كما أن هناك تأييداً واضحاً لفكرة العمل الفريقي واعتبار المسؤولية  والمشاركة الاجتماعية بمثابة نجاح لأي عمل تنموي.
الحضور والغياب في قراءة اللوحة التشكيلية
Authors: Mahdi Nada Abudl Hadi
Published: June 2021

يُعد مفهوم الحضور والغياب أحد مقولات (دريدا) التفكيكية لان جميع إجراءات العملية النقدية للتفكيك تخضع لحضور الدوال وغياب المدلول. وعلى هذا الاساس حددت الباحثة إحداثيات بحثها الموسوم "الحضور والغياب في قراءة اللوحة التشكيلية (الرسم) " تضمن الفصل الاول – الإطار المنهجي – مشكلة البحث والتي لُخصت بالسؤال: كيف تتم قراءة اللوحة التشكيلية على وفق الحضور والغياب؟  " وجاءت أهمية البحث متمثلة بأهمية موضوع النقد الفني بصفتهِ أحد اتجاهات التربية الفنية المعاصرة. أما هدف البحث فقد كان –الكشف عن كيفية قراءة اللوحة التشكيلية على وفق اليات الحضور والغيابِ. وتضمن الفصل الثاني - الاطار النظري ودراسات سابقة- المبحث الأول جاء بعنوان– التفكيكية كاتجاه نقدي معاصر – في حين حُدد المبحث الثاني بعنوان- قراءة اللوحة التشكيلية. اما الفصل الثالث – منهجية البحث واجراءاته - فجاء من خلال تحديد المنهج الوصفي التحليلي بصفته الاقرب لمتطلبات البحث الحالي وتم تحديد مجتمع البحث وعينتهِ واداة البحث وتناول الفصل الرابع عرض النتائج والاستنتاجات والتوصيات والمقترحات وختم البحث بقائمة المصادر.
إنموذج العوامل الستة للسعادة لدى طلبة الجامعة
Authors: Salman Sara Hassan , Al-Ali Majida Hillel
Published: June 2021

يهدف البحث الحالي الى التعرف على ( العوامل الستة للسعادة لدى طلبة الجامعة  )  و تكونت العينة من (400) طالب و طالبة من طلبة الجامعة المستنصرية  في كل من التخصصين العلمي و الانساني للعام الدراسي (2019 – 2020) و بواقع (177) من التخصصات العلمية و (223) من التخصصات الانسانية و بواقع (202 ) من الذكور و (108) من الاناث. و لتحقيق ذلك تم اعتماد مقياس (2006 Rosemry A Abbott, al) المعرب من قبل (الجمال 2013) و الذي يتألف من (42) فقرة وفقا لنظرية Ryff (أنموذج العاومل الستة للسعادة) و هو من النوع التقريري الذي يتم الاستجابة على فقراته في ضوء مقياس خماسي ( تنطبق علي تماماً ، تنطبق علي كثيراً ، تنطبق علي قليلاً ، تنطبق علي نادراً ، لا تنطبق علي ابداً)  و تصحح جميع الفقرات بالاتجاه الايجابي (1،2،3،4،5) و ان اعلى درجة ممكن ان يحصل عليها المستجيب (175) و اقل درجة هي (35) و بمتوسط فرضي (105) .و اظهرت نتائج  البحث الحالي لدى عينة البحث ان اكثر العوامل استعمالا هو عامل  الاستقلالية في المرتبة الاولى، ثم يليه عاملي  التمكن البيئي  و العلاقات الايجابية مع الآخرين في المرتبة الثانية و اقل العوامل استعمالا من العوامل الستة  هي العوامل الثلاثة و هي  عامل النمو الشخصي و الحياه الهادفة و تقبل الذات .
التغذية الراجعة العصبية
Authors: Jaber Abrar Hasan , Al-Hilo Buthaina Mansour
Published: June 2021

ان تقنية التغذية الراجعة العصبية تعد من ابرز التقنيات العلاجية الحديثة والمطورة القائمة على اليقظة الذهنية، فقد كانت هناك دراسات عدة تبحث في مدى تأثيرها على اعتبار انها شكل من اشكال الاشراط الفعال لنشاط الدماغ الكهربائي، التي يعزز النشاط الايجابي بالاثابة ويمنع ظهور النشاط السلبي، وتعمل على تغيير سطح خلايا الدماغ والذي يؤثر على فعالية الدماغ والتحسين من اداء المعالجات المعرفية فيه، ويمكن التعرف على أنماط مختلفة من النشاط الكهربائي من خلال وضع الأقطاب الكهربائية على فروة الرأس وتسجيل تلك الأنشطة القشرية لمناطق المخ القريبة منها -المعروفة باسم موجات الدماغ- ومن خلال السعات والترددات تم تصنيف مكونات التردد المختلفة في الدماغ إلى امواج دلتا وثيتا وألفا وبيتا وكاما ويمثل كل منهما وظيفة فسيولوجية معينة واي خلل فيها يمثل ما يسمى باعراض الاضطرابات النفسية المتنوعة لذلك فان اعادة تنظيم هذه الامواج يساعد في التعافي من هذه الاعراض. وهناك انواع مختلفة من التغذية الراجعة العصبية منها التغذية الراجعة العصبية السطحية  تستعمل لتغيير سعة أو سرعة موجات دماغية في مواقع معينة من الدماغ والتغذية الراجعة العصبية القشرية البطيئة على تحسين اتجاه الإمكانات القشرية البطيئة وتوفر بيانات التغذية الراجعة العصبية ردود أو ملاحظات حول تدفق الدم إلى الدماغ  اضافة الى انها تقدم مقارنة مستمرة لتغيرات النشاط الكهربائي في الدماغ بقاعدة بيانات منهجية لتوفير تغذية راجعة مستمرة، وتعد تقنية التصوير بالرنين المغناطيسي الوظيفي fMRI أحدث أنواع التغذية الراجعة العصبية لتنظيم نشاط المخ بناءً على لنشاط المناطق القشرية العميقة في المخ.
المتخيل السردي بين آراء القدماء والمحدثين
Authors: Khalif Ghanim AbdulSada , Hassan Essam Asal
Published: June 2021

المتخيل السردي تصور ذهني يمكن ان يتوافق مع الواقع أو يتنافى معه، ولقد أدرك الأدباء والنقاد منذُ القدم أهمية الخيال والمتخيل في عملية الخلق الإبداعي الأدبي، وعندما وضعنا أيدينا على معانٍ وتعريفات مختلفة من الدلالة الاصطلاحية لبعض المفكرين والبلاغيين والنقاد وجدنا أنها تفاوتت في ما بينها في تحديد ماهيته واختلاف نظرة الواحد منهم عن الآخر عن حقيقة هذا المفهوم ،فكل يعطي رأيه على حسب مذهبه ومعرفته وأيدلوجيته الشخصية، ابتداءً من الفكر الفلسفي القديم وانتهاءً إلى الفكر الفلسفي والنقدي الحديث، ومن هنا سنحاول تسليط الضوء على الاطر التاريخية لمفهوم المتخيل السردي متبعين التسلسل الزمني لأهم الآراء النقدية والفلسفية التي تناولت هذا المفهوم.
الأطر الإخبارية للأزمة الخليجية في قناتي الجزيرة والعربية
Authors: Fadel Ali Abbas , Abdalhassan Mustafa A.
Published: June 2021

يهدف البحث إلى معرفة الأطر الإخبارية التي ابرزتها أو استبعدتها قناتا "الجزيرة والعربية" في معالجة الأحداث المرتبطة بالأزمة الخليجية، ويعد هذا البحث من البحوث الوصفية، اذ استخدم المنهج المسحي بأسلوب تحليل المضمون لعينة عشوائية منتظمة من نشرات الاخبار الرئيسة في القناتين عن طريق استمارة تحليل مضمون اعدت لهذا الغرض وخضعت للتحكيم من قبل مجموعة خبراء في مجال الإعلام والعلوم السياسية لمعرفة مدى صلاحية فقراتها.

وتوصل الباحث الى عدد من النتائج أهمها، أنها أظهرت الأطر الرئيسة للأزمة الخليجية من حيث المضمون للقناتين في ثمانية أطر رئيسة هي (الاطر المطروحة لتسوية الازمة، اطر الصراع، اطر أسباب الازمة، الأطر الاقتصادية، الأطر الاستراتيجية، الأطر القانونية، الأطر الإنسانية، اُطر الاثار المترتبة على الازمة) مع تباين حجم الانتقاء والإبراز أو الاستبعاد بين القناتين، إذ جاءت قناة الجزيرة في المرتبة الأولى في ابراز فئات الأطر: (الأطر المطروحة لتسوية الأزمة، اطر الصراع، الأطر الاستراتيجية، الأطر القانونية) فيما أبرزت قناة العربية الأطر: (الأطر الاقتصادية، اطر أسباب الازمة، اطر الاثار المترتبة على الازمة) جاء ابراز كل قناة لأطر معينة وتفوقها على الآخر متسق مع سياسات كل دولة تتبعها القناة.
الشعر الفارسي في العصر الساماني
Authors: Mohammed Emad Jasim , Majeid Rana Ali
Published: June 2021

إن الأسلوبیة علم لیس بقدیم، وهو نوع من الدراسة الأدبیة اللغویة التي یدرس فيه المستویات اللغویة المجازیة البدیعیة المؤثرة في النصوص الشعریة والنثریة، وعلی الرغم من المعارضة الشدیدة له الا أنه اصبح خلال السنوات الخمسین الاخیرة علماً مستقلاً بذاته. لقد اخترنا الدراسة الأسلوبیة في أدب العصر الساماني بسبب نتاجهم الأدبي والفکري الزاخر، فالشعراء السامانیون کانوا یوظفون الأسلوبیة في لوحاتهم، فیعدون اللغة وسیلة الشعر وأدائه، وهذا ما تناولناه في دراستنا( الشعر الفارسی في العصر الساماني/" دراسة أسلوبیة ") یعنی( شعر فارسی در دورۀ سامانی/" بررسی سبکشناختی").وقد استعنا فی دراستنا هذه أولاً: بالمنهج التاریخي للتعریف بالأدب الساماني و تأثیر الأوضاع الاجتماعیة والسیاسیة في المجتمع الساماني آنذاک، وکذلک بالمنهج الوصفي لوصف المستویات اللغویة والمجازیة المستعملة في قصائد الشعراء السامانیین ونصوصهم النثریة المعروفة؛ فوجدنا أن الشاعر یبقی سید الموقف لصدق تجربته الشعریة مظاهر منها قدرة الشاعر علی نقل الأسالیب اللغویة نقلاً فنیاً للآخرین مما یولد في نفوسهم الأحاسیس والمشاعر التي لاتختلف کثیراً عن مشاعره وأحاسیسه حینما یکون الشاعر مبدعاً متمیزاً عن غیره من الناس العادین.
الخصائص المورفومترية لاحواض شرق محافظة واسط باستعمال نظم المعلومات الجغرافية
Authors: Abood Abdullah Sabbar , Abbass Hamza Jassim
Published: June 2021

اهتم هذا البحث في الكشف عن الخصائص المورفومترية لاحواض اودية ترساغ وكلال بدرة والزيادي وحوض وادي الشهابي باستخدام نظم المعلومات الجغرافية واساليب التحليل الكمي لظواهر سطح الارض المختلفة في المنطقة. وأظهرت دراسة الخصائص المورفومترية اقتراب شكل الاحواض من الاستطالة وابتعادها عن الاستدارة، وهذا يعني تباطؤ وصول الموجات المائية الى مخارج الاحواض, ومن ثم زيادة حجم الضائعات المائية بالتسرب والتبخر, مما يجعل دلالة خطر الفيضان قليلة نسبياً لهذه الاحواض.
الخوف من الحسد وعلاقته بالتشاؤم الدفاعي لدى طلبه الجامعة
Authors: Yonus Yasmin Jirjeis
Published: June 2021

تعد قوه الاعتقاد في الحسد متأصلة لدى الافراد وخصوصاً في اغلب المجتمعات وذلك من خلال اشاراتهم لربط الاعتقاد ببعض المظاهر السلبية, فالأشخاص الذين يخافون الحسد يكونون اكثر تشاؤم لمواقف الحياة, فالحزن يجعل الانسان يركز على الجوانب السلبية والرديئة في موضوع ما وعلى العكس من ذلك التفاؤل يجعل الانسان يركز على الجوانب الايجابية مهما تكن المواقف ضاغطه في الحياة من احكام في المواجه والتصدي لضغوط الحياه المختلفة, لهذا فإن التشاؤم الدفاعي يجعل الافراد اكثر تنظيم عال لذواتهم فهو ميل الى تنظيم العواطف والدافعية ووضع اساليب وخطط للتعلم والانجاز ومواجه المخاوف ومن ضمنها الافكار والانفعالات والمشاعر السلبية ومنها الخوف من الحسد .

فالخوف من الحسد مشكله اساسيه وذلك لان الانسان ليس فقط مؤذيا للإنسان وانما حسودا له ايضا، فالفرد الحاسد خاضع الى قوى اللاشعور في كثير من الاحيان وهذا يؤدي الى التشاؤم الدفاعي لمواجهه الافكار السلبية في المواقف الحياتية الضاغطة التي يتطلب من الانسان مواجهتها في المجتمع وتكمله مسيره حياته

وقد طبق المقياس على طلبة الجامعة من التخصص العلمي الانساني وكان عدد العينة يتكون من 100 طالب وطالبة كانت النتيجة بأن كل من الجنسين لديهم خوف من الحسد وتشام دفاعي لتكملة مسيرة الحياة.
Diskursive Brückenschläge: Medien, Maskulismus, Rechtsextremismus
Authors: Beck Dorothee
Published: June 2021

In dem Beitrag diskutiere ich, in welcher Hinsicht Print- und Online-Nachrichtenmedien mit Männlichkeitsthemen konservative und liberale Positionen einerseits und rechtsextreme Positionen andererseits diskursiv verschränken. Dazu erläutere ich Spannungsverhältnisse und Überlappungen maskulistischer und rechtsextremer Konzepte von Männlichkeit. Im Zentrum stehen die Legitimität von Gewalt und eine behauptete Krise der Männlichkeit. Basis ist das Projekt „‘Genderismus‘ in der medialen Debatte. Themenkonjunkturen 2006 bis 2016“, in dem ich Artikel in der Frankfurter Allgemeinen Zeitung, der Zeitung Die Welt, der Süddeutschen Zeitung und auf Spiegel Online einer qualitativen Inhalts- und einer Frame-Analyse unterzogen habe. Anhand der Befunde zeige ich die zentrale Bedeutung maskulistischer Positionen für mediale Diskursbrücken zwischen konservativen und liberalen Kreisen und dem Rechtsextremismus. In einer ersten Phase von 2007 bis 2013 wird der Wandel von Männlichkeit(en) überwiegend kritisch-konstruktiv verhandelt. In einer zweiten Phase 2016 dienen das Konzept soldatische Männlichkeit und die behauptete Krise der Männlichkeit dazu, männliche Hegemonie zu resouveränisieren.
Pola Interaksi Edukasi dalam Genelogy Tradisi Keilmuan Jami'al-Azhar
Authors: Syamsuddin Zulfahmi , Isyraqi Jamil Asyraf , Adabi Abdul Kadir Fakhrul
Published: June 2021

This article discusses Jami 'al-Azhar as a center for the knowledge study and the holistic interaction of teacher-student relationships. On the other hand, the position of teachers continues to be marginalized in the digital era. Hence, it is pivotal to look back at the teacher-student relationship that has prevailed in the history of Islamic education, especially in Jami 'al-Azhar. The research methodology employed literature review with a historical approach through primary and secondary source analysis. This study found that Jami 'al-Azhar was a center for the Islamic studies and study of science, initially aimed as propaganda for the Kingdom of Fathimiyah to perpetuate Shi'i understanding. However, the rank continued to develop to give a role as a center of thought and knowledge that gave birth to scholars from various schools of thought. One of its uniqueness as a center for the study of science is to perpetuate the interaction of teacher-student relationships in various traditions. Among the most prominent traditions are sanad, ijazah, suhbah, and talaqqi. Therefore, it can be concluded that the practice of teaching at Jami 'al-Azhar is manifested through the knowledge geneology and mentor system
Nilai Nasionalisme dalam Hikayat Perang Sabil Teungku Chik Pantee Kulu
Authors: Rizal Syamsul
Published: June 2021

This article discusses nationalism in the sabil war saga written by Teungku Chik Pantee Kulu. The sabil war saga written by Tengku Chik Pantee Kulu is a saga found in Acehnese society and can give the spirit of defending the country after listening to it. This saga was written in 1873 after he returned from Mecca and at that time Aceh fought against the Dutch. This research method uses literature study with a hermeneutic approach. The primary data source is Ali Hasjmy's book, Aceh Literary Contributions in the Development of Indonesian Literature, Jakarta: Bulan Bintang, 1977. The results of the analysis show that there are five values of nationalism in the sabil war saga by Teungku Chik Pante Kulu, namely love for the homeland, self-sacrifice, interest country above personal interests, has a heroic spirit, and does not give up easily.
Tarihin En Kapsamlı Soğuk Zincir Uygulaması: Koronavirüs (Covid-19) Aşısının Lojistiğinde Karşılaşılan Zorluklar
Authors: ÇEVİK Veli Ahmet
Published: June 2021

The coronavirus pandemic, one of the biggest pandemics of the last century, which emerged in Wuhan, China in the last months of 2019, continues to negatively affect life all over the world. The measures taken for the pandemic did not stop the spread of the disease and revealed medical requirements. Vaccines have been one of the most effective medical ways of preventing diseases. Vaccination studies for coronavirus disease started shortly after the emergence of the disease, and more than a hundred vaccine candidates were announced in about a year, and the distribution of those who passed the necessary stages was approved. However, the storage, transportation and distribution of some of these vaccines required very low temperatures below zero degrees, unlike the previous ones. The distribution and delivery of vaccines under these conditions has revealed the importance of cold chain logistics applications infrastructure. In this study, based on the priority issues of the World Health Organization in the logistics of vaccines, the potential difficulties that will arise in the production, allocation, distribution and application processes of coronavirus vaccines have been investigated.The data source of the study was the guidelines of the World Health Organization and various industry reports, which were secondary data previously revealed through primary research. Lack of cold chain infrastructure in storage and distribution activities, unequal distribution and anti-vaccination were found to be the biggest challenges facing vaccination activities.
İzmir’de İkame Bir Türkçe Mizah Dergisi: İlâve-i İntibah (1875)
Authors: Demirkol Gökhan
Published: June 2021

Although Istanbul is the heart of the Ottoman press, İzmir is an important city for the Ottoman society to meet the "newspaper" phenomenon. The Turkish press in İzmir, where the press in foreign languages developed, started with the Aydın newspaper published in 1869. Aydın newspaper, which has the status of an official newspaper, was followed by the Devir newspaper published in 1872. The third Turkish newspaper published in İzmir, after Aydın and Devir newspapers is İntibah. Limited information is available about this newspaper, as no copies of it have survived. İntibah newspaper ordered new typeface and tools in order to eliminate the printing errors it experienced due to the typeface. In order not to leave the readers without a newspaper in the required time for the ordered material to reach İzmir, it decides to publish a copy named İlâve-i İntibah, printed with lithography. However, this initiative is not accepted by the official authorities. This study focuses on the copy named İlâve-i İntibah published by İntibah newspaper. The study aims to reveal that the İlâve-i İntibah copy is a humor magazine in terms of content and within this context, İzmir is the second Turkish humor magazine published after Kara Sinan, the first Turkish humor magazine. It is thought that the study will make a significant contribution to the literature on Turkish Press History, especially İzmir Press History.
L'incerta fede
Authors: Cipriani Roberto
Published: June 2021

Dopo venticinque anni dalla ricerca su La religiosità in Italia di Vincenzo Cesareo, Roberto Cipriani, Franco Garelli, Clemente Lanzetti e Gianfranco Rovati (Mondadori, Milano, 1995), questa nuova indagine presenta una rilevante novità: l'approccio non è stato solo quantitativo (mediante somministrazione di un questionario a un campione statisticamente rappresentativo dell'intera popolazione italiana, costituito da 3238 intervistati, di cui dà conto in particolare Franco Garelli nel suo Gente di poca fede. Il sentimento religioso nell'Italia incerta di Dio, il Mulino, Bologna, 2020), ma ha avuto anche un carattere qualitativo, attraverso interviste del tutto libere oppure semiguidate a un insieme di 164 soggetti, opportunamente scelti sul territorio nazionale (seguendo criteri non lontani dal quadro demografico complessivo). Ne risulta uno scenario assai variegato e intrigante che attesta la persistenza di forme di credenza e ritualità, ma apre anche prospettive problematiche sul futuro della fede. Sono esaminati soprattutto i temi della vita quotidiana e festiva, della felicità e del dolore, della vita e della morte, della rappresentazione di Dio, della preghiera, dell'istituzione religiosa e di papa Francesco.
Enhancing the Efficiency of Soybean Inoculant for Nodulation under Multi-Environmental Stress Conditions
Authors: WONGDEE JENJIRA , YUTTAVANICHAKUL WATCHARIN , LONGTHONGLANG APHAKORN , TEAMTISONG KAMONLUCK , BOONKERD NANTAKORN , TEAUMROONG NEUNG , TITTABUTR PANLADA
Published: June 2021

The development of rhizobial inoculants with increased resistance to abiotic stress is critical to mitigating the challenges related to climate change. This study aims at developing a soybean stress-tolerant Bradyrhizobium inoculant to be used under the mixed stress conditions of acidity, high temperature, and drought. Six isolates of Bradyrhizobium with high symbiotic performance on soybean were tested to determine their growth or survival abilities under in vitro conditions. The representative stress-tolerant Bradyrhizobium isolates 184, 188, and 194 were selected to test their ability to promote soybean growth under stress conditions compared to the type strain Bradyrhizobium diazoefficiens USDA110. The plant experiment indicated that isolate 194 performed better in symbiosis with soybean than other Bradyrhizobium strains under stress conditions. Based on the stress tolerance index, soybeans inoculated with isolate 194 showed a high growth performance and significantly better nodulation competition ability than USDA110 under several stress conditions. Interestingly, supplementation of sucrose in the culture medium significantly enhances the survival of the isolate and leads to improved plant biomass under various stress conditions. Analysis of the intra-cellular sugars of isolate 194 supplemented with sucrose showed the accumulation of compatible solutes, such as trehalose and glycerol, that may act as osmoprotectants. This study indicates that inoculation of stress-tolerant Bradyrhizobium together with sucrose supplementation in a medium could enhance bacterial survival and symbiosis efficiency under stress conditions. Although it can be applied for inoculant production, this strategy requires validation of its performance in field conditions before adopting this technology.
The supervisory board as an instrument of internal corporate governance in a limited liability company
Authors: Pietrzak Marzena
Published: June 2021

The supervisory board is a body of authority in the company treated as the basic internal mechanism of corporate governance. The aim of this article is to indicate the importance of the corporate supervision using the example of the supervisory board as a statutory body exercising permanent supervision over the activities of a limited liability company. The study attempts to determine what powers of the aforementioned body should be extended in the articles of association and, optionally, in other corporate documents. This article has been written from a perspective of a legal-dogmatic approach that forms the basis of the analysis of the presented problems, using applicable legal provisions and relevant literature. The conducted analysis shows that the power of the supervisory board cannot be increased in a way that infringes the functions of other company bodies. The supervisory board is expected to be involved in the day-to-day operations of the limited liability company and to make strategic decisions.
Cappell, Ezra, and Jessica Lang, eds. Off the Derech: Leaving Orthodox Judaism. SUNY Series in Contemporary Jewish Literature and Culture. Albany, NY: SUNY Press, 2020.
Authors: Berkovic Sally
Published: June 2021

Review of Cappell, Ezra, and Jessica Lang, eds. Off the Derech: Leaving Orthodox Judaism. SUNY Series in Contemporary Jewish Literature and Culture. Albany, NY: SUNY Press, 2020.
The Missing Yemeni Children Affair – How Could It Happen?
Authors: Eraqi Klorman Bat-Zion
Published: June 2021

This article aims to position the phenomenon of the Missing Children within the broad context of the relations between Yemeni Jews and the hegemonic Eastern European Yishuv society, and as a continuation of institutional and social stance towards them. It is further argued that the Yishuv leadership's attitude toward the Yemenis signaled its conduct toward Mizrahi Jews in general.
The Yemeni, Mizrahi, and Balkan Children Affair: Lost Infants, Shattered Motherhoods
Authors: Amir Ruth
Published: June 2021

Between 1948 and 1954, at least 1,500 children between 0-4 years had disappeared from childcare facilities and hospitals in tent camps, transit camps, and hospitals in Israeli towns. About two-thirds were of Yemeni origin. Although these disappearances follow a shared pattern, the Yemeni case stands out due to a directive issued by the cabinet that ordered the forcible removal of Yemeni infants to infants’ homes in the immigrants’ camps. Three commissions of inquiry investigated this ethnically-based child-removal policy, yet its dire consequences were never challenged or reviewed. What remains missing from the accounts is a gendered and intersectional perspective of the involvement of women’s organizations and the mothers’ experiences.
Thalassemia and Hemoglobinopathies Screening by Osmotic Fragility (OF) and Dichlorophenol Indophenol Precipitation (DCIP) Tests Among Vocational Students in Ubon Ratchathani Province
Authors: Munthreepak Rungnapa , Suthutvoravut Somsak , Vongprasert Jumlong
Published: June 2021

Background: Thalassemia and hemoglobinopathies are the most common and clinically serious single gene disorders. Screening by osmotic fragility (OF) test and dichlorophenol indophenols precipitation (DCIP) test have been found to be effective and low-cost approaches to identify those who are carriers especially among young population.

Objective: To study the prevalence rates of abnormal of OF test and/or abnormal DCIP test among vocational students in Ubon Ratchathani province.

Methods: This cross-sectional research collected data from 311 students aged 15 to 19 years in a vocational school in Ubon Ratchathani, Thailand. OF and DCIP tests were done after participants signed consent to join the study. Knowledge and attitude towards thalassemia and thalassemia screening was obtained from self-administered questionnaires. Chi-square and Fisher exact tests were performed to examine the association between variables.

Results: Of 311 students, 124 (39.9%) students had abnormal OF test or DCIP test or both, 72 (23.2%) students had both DCIP and OF tests positive. The final diagnosis was that 75.8% had hemoglobin E, 21.8% and 2.4% were α-thalassemia and β-thalassemia carriers respectively. Approximately, 91.4% of them considered thalassemia screening useful and necessary for premarital screening.

Conclusions: High incidence of abnormal OF test and/or DCIP test was found among vocational students in Ubon Ratchathani province, showing a predominance of hemoglobin E. Most of them agreed that thalassemia screening is useful for adolescents to avoid marriage among carriers.
Determination of Biological Properties of Plutella xylostella (Linnaeus, 1758) (Lepidoptera: Plutellidae)
Authors: GENÇ Hanife
Published: June 2021

Plutella xylostella (Linnaeus, 1758), the diamondback moth is an important pest in Brassicae cultivars in the world. However, description regarding different biological stages and information about performance parameters of P. xylostella are important to survey in fields and design an effective management. In this study, wild population of diamondback moth was adapted on white cabbage then cauliflower, broccoli and white cabbage leaves were tested under laboratory conditions at 20±2°C, 50% relative humidity and 16:8 (L:D) photoperiod. The development times were 23.41±0.38 days on white cabbage, 25.12±0.56 days on cauliflower and 26.05±0.56 days on broccoli leaves. The generation times were 25.03±0.42 days on cauliflower, 29.99±1.49 days on broccoli and 30.47±1.04 days on white cabbage leaves. The eggs were laid individually or in the shape of small groups on the host leaves. There were 4 instars based on molting and head capsule diameters of all tested hosts. In this study, durations of larval stages, the number of laid eggs, larval sex differentiation and fitness parameters of the diamondback moth were determined on cauliflower, broccoli and white cabbage host plants.
The Effect of Ideology on the Form and Content of Edward FitzGerald’s Translation of Khayyam's Rubaiyat
Authors: Mana Aleahmad
Published: June 2021

The present study attempted to examine Edward FitzGerald, who would translate Omar Khayyam's Rubaiyat (1859), was interested in Persian poetry. Translation deals with power and authority and most of the time the ideology of source text changes in favor of the dominant ideology of target text. Victorian people‘s scornful outlook toward East led to ideological manipulation of source texts by translators such as Fitzgerald. His strange reduction in his translations, especially in Khayyam's Rubaiyat results in the necessity of investigating his translation from ideological point of view. Surprisingly translation of Khayyam’s Rubaiyat has never been studied from ideological perspective and is unknown for many literary scholars. Victorian issues had a strong effect on FitzGerald‘s selection of some Khayyam's Rubaiyat.
Renewal of the agricultural machinery fleet within the framework of the Agribusiness Technology Modernization departmental project
Authors:   Ministry of Agriculture of the Russian Federation, Department of Crop Production, Mechanization, Chemicalization and Plant Protection, Burak P.I. , Golubev I.G. ,   Rosinformagrotekh
Published: June 2021

The dynamics of tractors, grain and forage harvesters registered by the state technical supervision authorities and purchased by agricultural producers are shown. Information is given on the share of machinery, which has been produced more than ten years ago, as well as on the energy supply of agricultural organizations.
Biophysics and experimental search for inhibiting harmonics of magnetic disinfecting equipment
Authors:   Donskoy Agrarian Research Center, Pakhomov A.I.
Published: June 2021

The disinfecting effect of the higher harmonics of the magnetic field has been substantiated, and their relationship with the equipment parameters has been shown. Using the analysis of spectrograms and a laboratory experiment, the inhibitory 23rd, 25th, and 30th harmonics were established, the presence of which in the spectrum of a two-pole electromagnet provides a high disinfection effect. The necessity of concentrating the spectrum of magnetic disinfecting equipment at the frequencies of the indicated harmonics in order to increase the efficiency of the method has been proved.
Development and research of a pneumatic seed drill seedmetering unit
Authors:   VIM, Akhalaia B.Kh. , Tsench Yu.S. ,   VIM, Mironovа A.V. ,   VIM
Published: June 2021

The design of a pneumatic sowing device operating on a vacuum and sowing seeds in a combined, dotted and nesting ways with the same intervals between seeds in a row and a different sowing pattern is presented. To do this, the sowing discs are equipped with magnetic plates with different numbers of holes of different diameters for sowing row-crop seeds and forage crops.
Implementasi Sistem Informasi e-Document Pada Dinas Pekerjaan Umum Kota Semarang
Authors: Susanto Daniel Prasetya
Published: June 2021

Penelitian ini bertujuan untuk  mengimplementasi sistem informasi E-Document pada Dinas Pekerjaan Umum dengan merancang sebuah aplikasi. Dan menganalisa kekurangan-kekurangan sebagai penghambat kemajauan dari perusahaan Dinas Pekerjaan Umum dan melakukan pengujian pada suatu program dan menyelesaikan desain yang sudah disetujui. Hal ini dikarenakan strategi manajemen perusahaan Dinas Pekerjaan Umum dalam pengelolaan penyebaran dokumen masih manual dan pengambilan keputusan pada perusahaan dapat dipermudah. Dalam penelitian ini penulis melakukan studi kasus menggunakan metode EAP karena dianggap dapat menyelaaskan bisnis yang ada dan Teknologi yang sudah berjalan sebelumnya. Metode ini dapat mengidentifikasi mulai proses bisnis sampai ke perencanaan implementasi sitem informasi yang akan dibuat. Berdasarkan analisa mulai dari aktifitas utama sampai aktifitas pendukung maka diperoleh portofolio aplikasi sistem informasi pada Dinas Pekerjaan Umum Kota Semarang yang diantaranya adalah Sistem Informasi Pelayanan Publik, Sistem Informasi E-Document, Sistem Informasi Gudang, Sistem Informasi Keuangan, dan Sistem Informasi Kepegawaian, dimana dalam perencanaan aplikasi tersebut, hasil proses bisnis Dinas Pekerjaan Umum Kota Semarang dapat berjalan lebih efektif. Dengan Enterprise Architecture Planning (EAP) dapat  dijadikan metode untuk mencapai sasaran bisnis Dinas Pekerjaan Umum Kota Semarang, selain itu keuntungan EAP adalah untuk mendukung pengambilan keputusan dan perencanaan yang baik. Walaupun penelitian dapat menghasilkan Sistem Infomasi yang mendukung cukup baik, namun masih perlu dilakukan peningkatan seperti upgrade Sistem oleh perusahaan agar dapat bersaing dengan manajemen perusahaan lain yang selalu mampu mengikuti kemajuan Teknologi.
Developing an Improved ITSM Framework for Ethio Telecom
Authors: Berihun Getamesay Biyadgilign , Teferi Dereje
Published: June 2021

Telecom service providers are engaged exhaustively in providing various kinds of IT services for their customers. These IT services should be customer-oriented, and quality-based to be competitive in the market. To this end, organizations should manage their IT services effectively and efficiently by introducing various Information Technology Service Management (ITSM) mechanisms. However, improving or developing optimal ITSM mechanisms is a subject of great concern that needs further investigation academically.

To the best of the researcher’s knowledge, little or no research has been conducted to design and develop ITSM frameworks for the telecom sector in Ethiopia. Previous studies focused on the implementation, adoption, tailoring, and system or model development for selected ITSM processes within the Ethiopian context. Ethio telecom (ET), the sole telecom service provider of Ethiopia, has a gap in the existing ITSM practices. Hence, this research study intends to investigate the current ITSM practice of Ethio telecom and propose an ITSM framework based on ITIL best practices that ensures the quality of IT services and improve customer satisfaction.
Absence of Pathogenicity in Non-Human Primates of Mutations Related to Retinoblastoma in Humans
Authors: Seuánez Héctor N , Viana Maria C , Tavares William C , Mendonça Vanessa , Brant Ayslan C , Boroniv Mariana , Lucena Evandro
Published: June 2021

The tumor suppressor, Human Retinoblastoma Susceptibility Gene (RB1) plays a prominent role in normal development, gene transcription, DNA replication, repair, and mitosis, and its complete biallelic dysfunction in retinoblasts is the main cause of retinoblastoma in humans. Comparisons between the reference, human RB1 coding region with its counterparts in 19 non-human primates showed that several RB1 alterations accompanying retinoblastoma in the human were present in several non-human primates without apparent pathological effects. Comparative analyses of molecular data were most useful for tracing the evolution of RB1, identifying the polarity of mutational events, the physico-chemical effects conferred by amino acid substitutions, and the number of codons under selection. These historic reconstructions indicated that several RB1 mutations found in retinoblastoma in the human were presumably atavistic, accounting for evolutionary regressions. Moreover, some same-sense RB1 mutations, despite specifying for the same amino acids, were probably ancient adaptations that took place in our evolutionary lineage.
Assessment of quality of life in patients with severe acne
Authors: Gryazeva N. V. , Tamrazova A. V.
Published: June 2021

Acne vulgaris is a common disease affecting up to 85 % of adolescents. Localization of dermatosis in cosmetically signifiant areas, the duration of the therapy and the formation of post-acne symptoms have a high psycho-emotional load and negatively affect the quality of life. Due to the fact that acne affects the most vulnerable and socially sensitive age group, it is imperative not to overlook psychological abnormalities such as anxiety, depression and suicidal thoughts. This review presents the types of diagnostic scales for assessing the quality of life of patients with acne, pathogenesis and risk factors for scar formation – the main factor affecting the self-esteem of patients with acne vulgaris, and also proposed new methods of combination therapy with the use of corticosteroids and isotretinoin in the treatment of severe forms.
Diseases of cardiovascular system in patients with severe and moderatesevere forms of psoriasis
Authors: Hotko A. A. , Pomazanova M. Yu. , Kozyr Y. V.
Published: June 2021

Psoriasis is one of the most common chronic recurrent dermatoses, which is not limited to skin lesions, leading to a violation of the functions of various body organ systems. The article presents the results of the analysis of the medical histories of patients of Clinical dermatovenerologic dispensary (Krasnodar Region of Russia) with moderate-severe and severe forms of psoriasis and concomitant cardiological pathology. The article presents data from 70 case histories of patients with moderate to severe psoriasis, the analysis of which shows the clinical and practical significance of comorbidity of psoriasis. From the analysis, we conclude that there is a direct relationship between the severity of the course of the cutaneous pathological process and the aggravation of the cardiological diagnosis. The higher the severity of psoriasis, the higher the risk of developing acute coronary syndrome, myocardial infarction and other cardiac pathology.
Role of matrix metalloproteinases in acne inflammation: pathogenesis, diagnosis, treatment, prognosis
Authors: Nazarenko A. R. , Potekaev N. N. , Lvov A. N. , Klyachko N. L. , Majouga A. G.
Published: June 2021

Modern therapeutic views on the pathogenesis of acne indicate the role of permanent inflammation and expand the arsenal of medicines and combined techniques necessary for the successful treatment of this chronic skin disease. The complex process of immune inflammation in acne with the participation of pro-inflammatory cytokines is due to the interaction of trigger factors and factors of innate immunity. It was found that C. acne is able to interact with markers of increased immunity, such as Toll-like and protease-activated receptors. Based on a detailed analysis of the literature in search systems like PubMed, eLibrary.ru, CyberLeninka, it was found that one of the key roles in inflammation in acne belongs to matrix metalloproteinases. Thus, C. acnes are involved in many processes in the pathogenesis of acne, including inflammation, hyperkeratosis and hyperproduction of sebum, which necessitates its eradication and is an important component of complex therapy. Minocycline (Minolexin) is a highly effective drug for the treatment of moderate to severe forms of acne, including a low-dose regimen, and is included in the European Treatment Guidelines. Minocycline is considered the most powerful inhibitor of MMP, has a pronounced anti-inflammatory effect and a high level of lipophilicity, quickly penetrates the lipid layer of the bacterium and intensively accumulates in the sebaceous glands.
Efficacy and safety of dupilumab in complex treatment of patients with severe atopic dermatitis
Authors: Kruglova L. S. , Shatohina Е. А. , Rudnevа N. S.
Published: June 2021

The increased level of interleukins IL-4 and IL-13 in the area of skin lesions, which are secreted by type 2 T-helpers, eosinophils and other immunocompetent cells, plays a main role in the pathogenesis of AD according to modern concepts. The genetically engineered drug dupilumab selectively binds to the subunit of IL-4Rα receptor complexes for IL-4 and IL-13 and inhibits the signaling function of these cytokines. The drug is approved for the treatment of patients with moderate to severe AD who have indications for systemic therapy, regardless of the use of topical corticosteroids from 6 years age. The efficacy and safety of dupilumab in the treatment of patients with atopic dermatitis has been confirmed by the results of numerous clinical studies. Material and methods.The study included 11 patients with moderate and severe AD at the age from 18 to 48 years. All patients received systemic treatment with dupilumab, topically used methylprednisolone aceponate (two times a day for the first 4 weeks, then a calcineurin inhibitor two times a day until the end of the observation period), emollients (two times a day). The initial dose of dupilumab was 600 mg (two injections of 300 mg at different injection sites), then 300 mg every 2 weeks. Results. After 6 months of complex therapy 73 % of patients achieved IGA 0/1. The SCORAD index decreased by an average of 71.7 % after 6 months. The mean value of the NRS scale decreased by 63.2 %. There were no adverse events reported that would lead to drug withdrawal. Conjunctivitis was noted in 2 (18.2 %) patients. Conclusion. There was a marked decrease in the intensity of the main clinical symptoms (SCORAD), including pruritus (NRS), a significant decrease in the manifestations of anxiety and depression (PROMIS).
Focus on gut microbiota in age-associated body changes
Authors: Agafonova E. V.
Published: June 2021

Aging is a physiologically programmed process. And the main paradigm of medicine of the future is the preservation of health and functionality in the fight against age-associated diseases as a cause of premature aging. But with what involutive changes can the gut microbiota be associated? After all, it is not bacterial cells that age, but the bacterial composition changes in connection with concomitant diseases. Therefore, it is important to track what changes the gut microbiota undergoes with age using the example of common gerontological syndromes such as changes in innate immunity, sarcopenia and cognitive impairment. There are cultural and biological research methods that demonstrate differences in the gut microbiota of the elderly and young people. However, it is impossible to determine the chronological age threshold, after which the composition of the microbiota begins to change, rather, these changes occur gradually. Thus, the question remains open for scientists, which physiological processes are associated with changes in the microbiota and loss of health. This will make it possible to establish whether the microbiota can be a target for diagnosing the health status during aging and what measures to regulate the composition and function of the microbiota are possible to maintain active longevity. This article will provide an overview of the latest data on microbiota and involutive changes.
Case of penile cancer in patient with scleroatrophic lichen
Authors: Ignatovskiy A. V. , Lasareva Yu. R.
Published: June 2021

Purpose. To describe a clinical case of penile cancer in a patient with sclerotrophic lichen. Material and methods. Data of anamnesis, medical clinical, histological and instrumental examination. Results. A case of rapidly progressing penile squamous cell carcinoma in a patient with a long history of sclerotrophic lichen and no previous therapy was described. Conclusions.The low level of awareness of primary care physicians about the manifestations of CSAL, as a consequence, the lack of treatment and progression of the disease, expressed in urethral stenosis and malignant transformation draws attention.
Effectiveness of microneedling in correction of involutive skin changes
Authors: Avagumyan M. A. , Gres S. N.
Published: June 2021

In clinical practice, as a rule, patients with involutive changesas well havea photodamage, it should be considered when choosing a method of correction. Microneedling, including the use of PRP and hyaluronic acid, arevery promising methods.

Material and methods. There were 50 patients under observation, who were divided into three groups: 1st group – 18 patients received microneedling and PRP, 2nd group – 17 people used microneedling of hyaluronic acid, 3rd group – 15 patients received microneedling. Four procedures were performed with an interval of 4 weeks.

Results. According to dermatological status index, PRP microneedlingshowed the effectiveness, the index decreased by 86 % in the group. In group 2, the average index for the group decreased by 56 %, in group 3–41 %.

Conclusions.Microneedling is an effective safe method for correcting involutive changes in the skin of the face, combined with signs of photoaging. To increase the effectiveness of microneedling, it is recommended to use autologous plasma with cells directly after the procedure applicationinto the form or the film.
Distribution and degradation of hyaluronic acid during subdermal administration
Authors: Surkichin S. I. , Gres S. N.
Published: June 2021

Hyaluronic acid (HA) is a viscoelastic gel. The substance has a high ability to deform. It also has properties such as plasticity, lift, ease of distribution, and tissue mobilization during facial muscle activity. The aim of the study was to evaluate the safety and effectiveness of HA at the microscopic level. The study was conducted in two stages. In the first stage, the tissue filler was injected bolus-subdermally to rats and rabbits. The second stage involved female volunteers. The drug was also administered to the problem areas on the face. In addition to the histochemical observation, the effectiveness of the procedure on the woman’s face was also evaluated. High safety was demonstrated, as well as an increase in the expression level of collagen and elastin fibers.
Acne and itch: Pathogenic role of neurogenic inﬂammation
Authors: Sidorenko Е. Е. , Lvov А. N. , Michenko А. V. , Sidorenko О. А. , Kolenko N. G.
Published: June 2021

According to the current concepts, pathogenesis of acne includes signifcant morphological and functional changes and hypercolonization of C. acnes of the sebaceous hair follicle. But most important input into pathogenesis of acne gives permanent inﬂammation, previously considered as a secondary pathophysiological reaction. Recently, much attention has been given to pruritus associated with acne lesions. This literature review analyzes the data concerning the pathogenetic role of neurogenic inﬂammation in acne; the clinical importance of itch in the overall presentation of the disease is underlined, and its inﬂuence on psychosomatic correlations is presented.
Certolizumab pegol in treatment of psoriasis and psoriatic arthritis: patient profiles, inspection, monitoring of safety
Authors: Khotko A. A. , Pomazanova M. Yu. , Kozyr Ya. V.
Published: June 2021

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Granuloma formation after injection of polycaprolactone dermal filler (case report)
Authors: Ikonnikova E. V. , Kruglova L. S.
Published: June 2021

A case of clinical observation of a patient with a granulomatous reaction developing in the region of both nasolacrimal grooves after the injection of a filler based on polycaprolactone (PCL) is presented. PCL is used in cosmetology as a filler and collagen synthesis stimulator. It is a biocompatible and biodegradable polymer with a proven safety profile. However, as with the introduction of other types of fillers, in some cases it can cause a granulomatous reaction of varying severity. The clinical observation of this case is of interest to practicing dermatologists, cosmetologists and plastic surgeons.