bluuebunny/crossref_metadata_2025 huggingface dataset:
Palliative Care in Patients With High-Grade Gliomas in the Neurological Intensive Care Unit
Authors: Rosenberg Jon , Massaro Allie , Siegler James , Sloate Stacey , Mendlik Matthew , Stein Sherman , Levine Joshua
Published: September 2019

Background:

Palliative care improves quality of life in patients with malignancy; however, it may be underutilized in patients with high-grade gliomas (HGGs). We examined the practices regarding palliative care consultation (PCC) in treating patients with HGGs in the neurological intensive care unit (NICU) of an academic medical center.

Methods:

We conducted a retrospective cohort study of patients admitted to the NICU from 2011 to 2016 with a previously confirmed histopathological diagnosis of HGG. The primary outcome was the incidence of an inpatient PCC. We also evaluated the impact of PCC on patient care by examining its association with prespecified secondary outcomes of code status amendment to do not resuscitate (DNR), discharge disposition, 30-day mortality, and 30-day readmission rate, length of stay, and place of death.

Results:

Ninety (36% female) patients with HGGs were identified. Palliative care consultation was obtained in 16 (18%) patients. Palliative care consultation was associated with a greater odds of code status amendment to DNR (odds ratio [OR]: 18.15, 95% confidence interval [CI]: 5.01-65.73), which remained significant after adjustment for confounders (OR: 27.20, 95% CI: 5.49-134.84), a greater odds of discharge to hospice (OR: 24.93, 95% CI: 6.48-95.88), and 30-day mortality (OR: 6.40, 95% CI: 1.96-20.94).

Conclusion:

In this retrospective study of patients with HGGs admitted to a university-based NICU, PCC was seen in a minority of the sample. Palliative care consultation was associated with code status change to DNR and hospice utilization. Further study is required to determine whether these findings are generalizable and whether interventions that increase PCC utilization are associated with improved quality of life and resource allocation for patients with HGGs.
Evidence of Validity for the Online Version of the Assessment of Adherence to Antiretroviral Therapy Questionnaire
Authors: de Brito Silva Bruno , de Brito Ariane , Monteiro Erika Pizziolo , Mondelo Gabriela Pasa , Remor Eduardo
Published: September 2019

A Patient-Reported Outcome (PRO) measure titled Cuestionario para la Evaluación de la Adhesión al Tratamiento Antiretroviral (acronym CEAT-VIH) is currently available in paper-and-pencil and digital (online assessment) formats. Due to the advantages of online assessment, the main objective of this work was to evaluate psychometric properties of the online version, in an international sample, to accumulate evidence of its validity and provide score norms for the questionnaire. A psychometric study was performed with an international sample of 1,470 participants, from 30 countries, to accumulate evidence of CEAT-VIH validity regarding internal structure and related external criterion (e.g., viral load, number of pills, and AIDS-related symptoms). Descriptive statistics and normative data for scores are also presented. The majority of participants were men (72.4%), aged 15 to 78 years old ( M = 39.3, SD = 12.6). A unidimensional model with five facets occurred as the observed variables converged, which presented a good model fit (comparative fit index [CFI] = 1.000; Tucker–Lewis index [TLI] = 0.999; standardized root mean square residual [SRMR] = 0.027; and root mean square error of approximation [RMSEA] [90% confidence interval, CI] = 0.009 [0.000, 0.038], p = .995). There was a weak invariance for the CEAT-VIH structure for language versions and countries. Cronbach’s alpha values for the instrument (17 items) were acceptable across language versions (.88-.96). Evidence of validity related to external criteria was achieved by associations (e.g., Spearman and Mann–Whitney) between CEAT-VIH scores and relevant clinical (e.g., CD4+ cells, viral load, number of pills, and AIDS-related symptoms) and sociodemographic (e.g., gender, age, employment status, education level, place of residence, and participation at local AIDS association) variables. In conclusion, the overall data on the evaluated psychometric properties allow recommendation of the use of this instrument in research and applied settings.
Spontaneous Regeneration of Medial Cuneiform Following Gunshot Wound
Authors: Reyes Ricardo , Türker Tolga , Latt L. Daniel
Published: September 2019

Level of Evidence: Level V, expert opinion.
Neoliberal environmentality in the land of Gross National Happiness
Authors: Montes Jesse
Published: September 2019

This paper explores how a growing trend towards neoliberalization throughout Bhutan manifests within environmental governance in particular. Bhutan’s well-known Gross National Happiness (GNH) development strategy can be seen to represent a shift towards a variegated governmentality more generally that increasingly exhibits neoliberal tendencies as the country seeks to negotiate its further integration into the global economy. Part of this integration entails efforts to promote ecotourism as a key element of the country’s future conservation strategy. Ecotourism has been described as a growing manifestation of a “neoliberal environmentality” (Fletcher, 2010) within environmental conservation policy and practice, and hence Bhutan’s promotion of ecotourism can be seen as contributing to the promotion of neoliberal conservation. Yet in practice, my analysis demonstrates that environmental governance in Bhutan is a complex of external neoliberal influences filtered through local formal and informal institutions, specifically a Buddhist worldview, a history of state paternalism and the Gross National Happiness governance model, all of which express contrasting governance rationalities. This study thus contributes to governmentality studies by promoting a variegated environmentality perspective that calls for more nuanced analyses beyond “variegated” neoliberalization. This perspective also affords a holistic understanding of discrepancies between the vision and execution of neoliberal conservation that can be attributed to the articulation of alternative rationalities in policy formulation and implementation.
Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling
Authors: Nath Disharee , Li Xiang , Mondragon Claudia , Post Dawn , Chen Ming , White Julie R. , Hryniewicz-Jankowska Anita , Caza Tiffany , Kuznetsov Vladimir A. , Hehnly Heidi , Jamaspishvili Tamara , Berman David M. , Zhang Fan , Kung Sonia H. Y. , Fazli Ladan , Gleave Martin E. , Bratslavsky Gennady , Pandolfi Pier Paolo , Kotula Leszek
Published: September 2019

Background

Prostate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease. ABI1, a member of WAVE complex and actin cytoskeleton regulator and adaptor protein, acts as tumor suppressor in prostate cancer but the role of ABI1 in EMT is not clear.

Methods

To investigate the molecular mechanism by which loss of ABI1 contributes to tumor progression, we disrupted the ABI1 gene in the benign prostate epithelial RWPE-1 cell line and determined its phenotype. Levels of ABI1 expression in prostate organoid tumor cell lines was evaluated by Western blotting and RNA sequencing. ABI1 expression and its association with prostate tumor grade was evaluated in a TMA cohort of 505 patients and metastatic cell lines.

Results

Low ABI1 expression is associated with biochemical recurrence, metastasis and death (p = 0.038). Moreover, ABI1 expression was significantly decreased in Gleason pattern 5 vs. pattern 4 (p = 0.0025) and 3 (p = 0.0012), indicating an association between low ABI1 expression and highly invasive prostate tumors. Disruption of ABI1 gene in RWPE-1 cell line resulted in gain of an invasive phenotype, which was characterized by a loss of cell-cell adhesion markers and increased migratory ability of RWPE-1 spheroids. Through RNA sequencing and protein expression analysis, we discovered that ABI1 loss leads to activation of non-canonical WNT signaling and EMT pathways, which are rescued by re-expression of ABI1. Furthermore, an increase in STAT3 phosphorylation upon ABI1 inactivation and the evidence of a high-affinity interaction between the FYN SH2 domain and ABI1 pY421 support a model in which ABI1 acts as a gatekeeper of non-canonical WNT-EMT pathway activation downstream of the FZD2 receptor.

Conclusions

ABI1 controls prostate tumor progression and epithelial plasticity through regulation of EMT-WNT pathway. Here we discovered that ABI1 inhibits EMT through suppressing FYN-STAT3 activation downstream from non-canonical WNT signaling thus providing a novel mechanism of prostate tumor suppression.
Delivering maternal mental health through peer volunteers: a 5-year report
Authors: Atif Najia , Bibi Amina , Nisar Anum , Zulfiqar Shaffaq , Ahmed Ikhlaq , LeMasters Katherine , Hagaman Ashley , Sikander Siham , Maselko Joanna , Rahman Atif
Published: September 2019

Background

Maternal depression affects one in five women in low-and middle income countries (LMIC) and has significant economic and social impacts. Evidence-based psychosocial interventions delivered by non-specialist health workers are recommended as first-line management of the condition, and recent studies on such interventions from LMIC show promising results. However, lack of human resource to deliver the interventions is a major bottle-neck to scale-up, and much research attention has been devoted to ‘task-sharing’ initiatives. Apeer-deliveredversion of the World Health Organization’s Thinking Healthy Programme for perinatal depression in Pakistan and India showed clinical, functional and social benefits to women at 3 months postpartum. The programme has been iteratively adapted and continually delivered for 5 years in Pakistan. In this report, we describe the extended intervention and factors contributing to the peers’ continued motivation and retention, and suggest future directions to address scale-up challenges.

Methods

The study was conducted in rural Rawalpindi. We used mixed methods to evaluate the programme 5 years since its initiation. The competency of the peers in delivering the intervention was evaluated using a specially developed Quality and Competency Checklist, an observational tool used by trainers to rate a group session on key areas of competencies. In-depth interviews explored factors contributing to the peer volunteers’ continued motivation and retention, as well as the key challenges faced.

Results

Our key findings are that about 70% of the peer volunteers inducted 5 years ago continued to be part of the programme, retaining their competency in delivering the intervention, with only token financial incentives. Factors contributing to sustained motivation included altruistic aspirations, enhanced social standing in the community, personal benefits to their own mental health, and the possibility for other avenues of employment. Long-term challenges included demotivation due to lack of certainty about the programme’s future, increased requirement for financial incentivisation, the logistics of organising groups in the community, and resistance from some families to the need for ongoing care.

Conclusions

The programme, given the sustained motivation and competence of peer volunteers in delivering the intervention, has the potential for long-term sustainability in under-resourced settings and a candidate for scale-up.
Enhancing enzymatic digestibility of waste wheat straw by presoaking to reduce the ash-influencing effect on autohydrolysis
Authors: Tang Wei , Wu Xinxing , Huang Chen , Huang Caoxing , Lai Chenhuan , Yong Qiang
Published: September 2019

Background

The acid buffering capacity of high free ash in waste wheat straw (WWS) has been revealed to be a significant hindrance on the efficiency of autohydrolysis pretreatment. Previous researches have mainly relied on washing to eliminate the influence of ash, and the underlying mechanism of the ash influencing was not extensively investigated. Presently, studies have found that cations can destroy the acid buffering capacity of ash through cation exchange. Herein, different cations were applied to presoak WWS with the aim to overcome the negative effects of ash on autohydrolysis efficiency, further improving its enzymatic digestibility.

Results

Results showed that cations can be adsorbed on the surface of the material by electrostatic adsorption to change the acid buffering capacity of WWS. The acid buffering capacity of 120 mM Fe2+ presoaked WWS is reduced from 226.3 mmol/pH-kg of original WWS to 79.3 mmol/pH-kg. This reduced the autohydrolysis pretreatment medium pH from 5.7 to 3.8 and promoted the removal of xylan from 61.7 to 83.7%. In addition, the enzymatic digestibility of WWS was enhanced from 49.7 to 86.3% by presoaking with 120 mM Fe2+ solution. The relationship between enzymatic accessibility and hydrophobicity with enzymatic digestibility of the autohydrolyzed WWS was analyzed.

Conclusions

The results showed that the acid buffering capacity of the high free ash was detrimental for the autohydrolysis efficiency of WWS. After WWS was presoaked with different cations, the acid buffering capacity of ash was weakened by cation exchange and electrostatic adsorption, which improved the autohydrolysis efficiency. The results expound that the enzymatic digestibility of WWS can be enhanced through presoaking to reduce the ash-influencing effect on autohydrolysis.
Petrophysical properties of the Muschelkalk from the Soultz-sous-Forêts geothermal site (France), an important lithostratigraphic unit for geothermal exploitation in the Upper Rhine Graben
Authors: Heap Michael J. , Kushnir Alexandra R. L. , Gilg H. Albert , Violay Marie E. S. , Harlé Pauline , Baud Patrick
Published: September 2019

The Muschelkalk, composed of Triassic limestones, marls, dolomites, and evaporites, forms part of the Permo-Triassic cover of sedimentary rocks that directly overlies the fractured granitic reservoir used for geothermal energy exploitation in the Upper Rhine Graben. Petrophysical data for this lithostratigraphic unit are sparse, but are of value for reservoir prospection, stimulation, and optimisation strategies at existing and prospective geothermal sites throughout the Upper Rhine Graben. To this end, we present here a systematic microstructural, mineralogical, and petrophysical characterisation of the Muschelkalk core (from the Middle to Lower Muschelkalk; from a depth of ~ 930 to ~ 1001 m) from exploration borehole EPS-1 at Soultz-sous-Forêts (France). First, we assessed the microstructure and mineral content of samples from six depths that we consider represent the variability of the available core. The majority of the core is composed of fine-grained, interbedded dolomites and marls; however, anhydrite and a dolomitic sandstone bank were found in the Upper and Lower Muschelkalk core, respectively. A larger suite of samples (from fifteen depths, including the six depths chosen for microstructural and mineral content analysis) were then characterised in terms of their petrophysical properties. The matrix porosity of the measured Muschelkalk samples is low, from ~ 0.01 to ~ 0.1, and their matrix permeability is below the resolution of our permeameter (≪ 10−18 m2). P-wave velocity, thermal conductivity, thermal diffusivity, specific heat capacity per unit volume, Young’s modulus, and uniaxial compressive strength range from 2.60 to 5.37 km/s, 2.42 to 5.72 W/mK, 1.19 to 2.46 mm2/s, 1.63 to 2.46 MJ/m3 K, 9.4 to 39.5 GPa, and 55.1 to 257.6 MPa, respectively. Therefore, and despite the narrow range of porosity, the petrophysical properties of the Muschelkalk are highly variable. We compare these new data with those recently acquired for the Buntsandstein unit (the Permo-Triassic unit immediately below the Muschelkalk) and thus provide an overview of the petrophysical properties of the two sedimentary units that directly overly the fractured granitic reservoir.
Procalcitonin and C-Reactive Protein As Markers of Bacteremia in Patients With Febrile Neutropenia Who Receive Chemotherapy for Acute Leukemia: A Prospective Study From Nepal
Authors: Shilpakar Ramila , Paudel Bishnu Dutta , Neupane Prakash , Shah Aarati , Acharya Bibek , Dulal Soniya , Wood Lori Anne , Shahi Rukmani , Khanal Usha , Poudyal Bishesh Sharma
Published: September 2019

PURPOSE

The purpose of this study was to evaluate the clinical significance of the biomarkers procalcitonin (PCT) and C-reactive protein (CRP) in patients with febrile neutropenia (FN) undergoing chemotherapy for acute leukemia.

METHODS

We conducted a prospective, observational study in patients who developed FN while undergoing chemotherapy for acute leukemia. PCT and CRP were obtained in patients who presented with FN. Blood cultures also were obtained. The primary goals were to evaluate the ability of PCT and CRP to predict bacteremia in patients with FN. The secondary goals were to assess the prognostic role of PCT and CRP and to assess the microbiologic profile and culture sensitivity patterns in the study population.

RESULTS

A total of 124 episodes of FN that involved 67 patients with acute leukemia occurred in the study. PCT was superior to CRP in the prediction of bacteremia. The median PCT level in the bacteremia group was 3.25 ng/mL compared with 0.51 ng/mL in the group without bacteremia ( P < .01). The median values of CRP in the bacteremia and without-bacteremia groups were 119.3 mg/L and 94.5 mg/L, respectively ( P = .07). There were no differences in median PCT and CRP in patients who died and those who improved. Of the 42 positive cultures, Gram-negative bacteremia was common (86%), and Escherichia coli was the most frequent organism isolated. Carbapenem resistance was seen in 39% of positive cultures.

CONCLUSION

PCT is an effective biomarker to predict bacteremia in patients with FN undergoing chemotherapy for acute leukemia.
The New (Emotional) Regime
Authors: Davidson Denise Z.
Published: September 2019

The fifteen months between April 1814 and June 1815 brought multiple regime changes, military defeat, and foreign occupation to France. This article examines this period of confusion through the lens of lived experience, using correspondence exchanged among a small circle of family and friends to consider how they reacted to events as they were happening. The author argues that these men and women used letters and the emotional expressions voiced in them to develop a sense of shared experience and to strengthen bonds among their allies. However, those emotional expressions remained subdued, suggesting that a new emotional regime of bourgeois restraint was emerging to replace the sentimentalism that had dominated public and private discourse during the previous decades. A “keep-calm-and-carry-on” mentality reassured the letter writers and their readers that they could rely on each other as they persevered.

Pendant les quinze mois s'étalant d'avril 1814 à juin 1815, la France a subi de multiples changements de régime, des défaites militaires et deux occupations. Cet article examine cette période trouble à travers l'expérience vécue en utilisant la correspondance privée d'un petit groupe d'intimes. Ces hommes et femmes racontent leurs expériences et expriment leurs réactions émotionnelles pour souder les liens avec leurs parents et amis, mais ces expressions restent restreintes, en contraste avec le sentimentalisme visible des années précédentes. Une mentalité de calme persévérance rassure les correspondants en donnant l'impression que leurs ami(e)s feront tout le nécessaire pour les soutenir.
Policing Colonial Migrants
Authors: Beaujon Danielle
Published: September 2019

In 1923 the Parisian Municipal Council created a special police unit to control North Africans in Paris, known as the Brigade Nord-Africaine (BNA). During its twenty-year tenure, the BNA controlled the North Africans they policed through intimation and violence, but also through personal knowledge of the community. The BNA's harsh tactics had to be balanced by its officers' admitted reliance on North Africans for information. This article explores both the uniquely discriminatory and colonial nature of the BNA and the nuanced, intimate relationships that developed between the officers and the North African community. A repatriation of colonial control, the BNA reified the difference of those it policed, uniquely targeting North Africans but also offering a space of possible agency for them in interwar Paris. The BNA gives us insight into policing in the 1930s, demonstrating the acceptability of targeted policing but also showing the limits of coercive power.

En 1923, le Conseil municipal de Paris créa une brigade destinée à contrôler les Nord-Africains domiciliés à Paris : la Brigade nord-africaine (BNA). Pendant ses vingt années d'existence, la BNA employa non seulement l'intimidation et la violence, mais aussi des tactiques reposant sur une connaissance intime de la communauté, pour contrôler celle-ci. Le travail de la BNA exigeait un équilibre entre la répression et une entente avec la communauté nord-africaine qui fournissait des renseignements essentiels aux officiers. Cet article examine d'une part la nature discriminatoire et coloniale de la BNA et d'autre part, les rapports intimes et nuancés qui se tissèrent entre la brigade et les Nord-Africains. Rapatriant à Paris des formes de contrôle coloniales, la BNA contribua à réifier la différence des Nord-Africains qu'elle surveillait tout en leur offrant une certaine capacité d'action limitée. Etudier la BNA permet d'élucider les préjugés des policiers de l'époque, tout comme les limites de leur pouvoir coercitif.
Unproblematic Altruists?
Authors: Robins Marianne Ruel
Published: September 2019

This article examines the ways in which values associated with Protestant rescuers have impacted the historiography of the rescue during the Holocaust and the testimonies of witnesses. It considers two regions, the Poitou and the Plateau Vivarais-Lignon, to analyze three moral assumptions: the rescuer as resister, as generous host, and as respectful Christian. Using anthropological approaches to hospitality, it reveals the shortcomings of these assumptions. First, the association of rescue and resistance, though understandable, obscures the chronology, the unevenness, and the relative safety of Protestant involvement in the rescue. Second, the rescuers' assumed generosity simplifies the reciprocity at work in hospitality as well as the materiality of the rescue. Third, a systematic characterization of rescue as altruism or expression of philo-Semitism prevents a more complex exploration of the relationships between Protestant hosts and Jewish guests. In particular, hospitality as a form of rescue could certainly generate mutual appreciation, but also acculturation and tensions.

Comment les valeurs associées aux protestants français ont-elles influencé, et les témoignages, et l'historiographie du sauvetage ? Cet article se penche sur trois figures morales associées au sauveteur protestant, celle du résistant, celle de l'hôte généreux, et celle du chrétien tolérant, et ce, dans deux régions, le Poitou et le Vivarais-Lignon. En s'appuyant sur une analyse anthropologique de l'hospitalité, il révèle les limites d'une approche morale du sauvetage. D'une part, l'association du sauvetage avec la résistance, quoiqu'en partie fondée, néglige les variations chronologiques, la variété des formes de participation et la sécurité relative dont bénéficiaient les sauveteurs français. D'autre part, la générosité présupposée des sauveteurs obscurcit la réciprocité à l'œuvre dans l'hospitalité ainsi que la matérialité du sauvetage. Enfin, associer systématiquement sauvetage et altruisme ou philosémitisme rend difficile une interprétation plus complexe des relations entre juifs et protestants. De fait, l'hospitalité offerte aux juifs au cours du sauvetage a pu générer aussi bien une appréciation réciproque que des tensions et des formes d'acculturation.
The American model of federal administrative law: remembering the first one hundred years
Authors: Mashaw Jerry L.
Published: September 2019

O modelo americano de direito administrativo federal: lembrando os primeiros 100 anos In this article, I want to explore the question of why early administrative law has been mostly invisible. In the course of that exploration I hope to do several things: first, I want to challenge the notion that federal administrative law was nonexistent during the first 100 years of the Republic. Second, I want to suggest a general model of the reach and functions of administrative law and compare the way that we understand that model to operate today with the way it operated in the period 1787 to 1887- roughly, the nineteenth century. Finally, I want to argue that recognizing the shape of nineteenth-century American administrative law can help us both to better understand the system or model of administrative law that we currently observe and to motivate inquiry into parts of that system that are currently neglected. In the end, I will argue that much of our administrative law remains mostly invisible and that we would do well to bring it into the light. Neste artigo, pretendo explorar a razão pela qual o direito administrativo tem permanecido, majoritariamente, invisível. No curso dessa exploração, pretendo fazer várias coisas: inicialmente, pretendo desafiar a noção de que o direito administrativo federal foi inexistente, durante os primeiros anos da República. Em segundo lugar, pretendo sugerir um modelo geral de pesquisa e funções do direito administrativo e comparar a forma pela qual percebemos que esse modelo opera, atualmente, com a forma como este operava, no período compreendido entre 1787 e 1887 - aproximadamente, no século XIX. Finalmente, pretendo defender que reconhecer o formato do direito administrativo americano do século XIX pode nos ajudar tanto a entender melhor o sistema do modelo do direito administrativo, atualmente observado, quanto a motivar o questionamento em relação às partes desse sistema que são, atualmente, negligenciados. No final, argumentarei que muito do nosso direito administrativo continua, majoritariamente, invisível, e que faríamos o correto trazendo-o à tona.
Escolha regulatória, controle judicial e a nova LINDB
Authors: Leitão Rômulo Guilherme , Gouveia Alessandro Samartin de
Published: September 2019

Este artigo trata da escolha regulatória e do controle pelo Judiciário dos atos dela decorrentes à luz da Lei de Introdução às Normas do Direito Brasileiro (LINDB). O objetivo geral é verificar como deve se pautar o julgador na discussão da validade de atos normativos da agência reguladora em processos comuns e, para esse fim, analisa-se o poder regulatório da agência no Brasil, a escolha regulatória como categoria jurídica singular, sua competência normativa e o posicionamento do Supremo Tribunal Federal sobre o assunto, especialmente as ADIs no 4.874 e 5.906; examina-se, ainda, a legalidade como princípio constitucional construído a partir de sua evolução, sua crise e sua definição na Constituição de 1988; e, por fim, investiga-se o controle judicial dos atos normativos consequentes de escolhas regulatórias, em hipóteses de controle concentrado e difuso de constitucionalidade, sendo este último o ambiente em que os arts. 20, 21, 23, 24 e 27 da Lei no 13.655, de 25 de abril de 2018, encontram melhor espaço para suas aplicações. This article deals with the regulatory choice and the Brazilian system of judicial review of the acts arising therefrom in light of the new Brazilian law´s interpretation (LINDB). The general objective is to verify how the judge should be guided in the discussion of the validity of regulatory acts of the regulatory agency in common proceedings and, for this purpose, the regulatory power of the agency in Brazil is analyzed, the regulatory choice as a unique legal category, its regulatory competence and the position of the Federal Supreme Court on the matter, especially the ADIs no. 4.874 and 5.906; it also examines legality as a constitutional principle built on its evolution, its crisis and its definition in the 1988 Constitution; and, finally, it investigates the judicial review of normative acts resulting from regulatory choices, in cases of concentrated and diffuse judicial review of constitutionality, the latter being the environment in which Articles 20, 21, 23, 24 and 27 of Law No. 13.655, of April 25, 2018, find better space for its applications.
Factors associated with the utilization of long-acting reversible contraceptives among family planning clients at the Pameungpeuk Rural Hospital, Indonesia
Authors: Harzif Achmad Kemal , Mariana Ana , Malik Devi Marischa , Silvia Melisa , Lovita Bara Tracy
Published: September 2019

Background: Uncontrolled population development can prompt an assortment of populace issues and can be one of the reasons for increasing maternal death rates. The utilization of contraceptives in Indonesia was progressively dominated by injectable contraceptives and pill contraceptives in 2015 (52.21% and 24.36%, respectively). However, the rate of termination of the use of short-acting contraceptives by family planning clients was higher than other methods, therefore the use of short-acting contraceptives is less efficient than long acting reversible contraceptives (LARCs)  for longer term spacing because it is easy to skip a treatment for economic or other reasons, which can result in unintended pregnancy. Therefore, the National Family Planning Program in Indonesia is encouraging the use of LARCs to control population growth. Pameungpeuk is a region which has the second largest population, with the highest total fertility rate in South-West Java. The proportion of active users of LARCs in Pameungpeuk is very low (10.66%). This study aimed to analyze factors associated with the utilization of LARCs among family planning clients at the Pameungpeuk Rural Hospital.

Methods: This study design was cross-sectional with systematic random sampling. The sample group in this study was 84 family planning clients. We performed statistical analyses using chi-square test.

Results: We found significant associations between the age of women (p=0.024), the cost of contraception (p=0.022), knowledge (p=0.042), beliefs (p=0.002), skill of health workers (p=0.008) and support from health workers (p=0.014). However, education (p=0.212), family income (p=0.087), attitude (p=0.593), exposure to information on LARCs (p=0.378), support from partners (p=0.094), support from friends (p=0.414) and the support of community leaders (p=0.367) had no significant association with the utilization of LARCs.

Conclusions: These findings highlight a critical need for improved education among family planning clients at the Pameungpeuk rural hospital regarding the use of LARCs for both medical and elective reasons.
Insights from quantitative and mathematical modelling on the proposed WHO 2030 goals for Chagas disease
Authors:   Collaborating Group on Chagas Disease Modelling
Published: September 2019

Chagas disease (CD) persists as one of the neglected tropical diseases (NTDs) with a particularly large impact in the Americas. The World Health Organization (WHO) recently proposed goals for CD elimination as a public health problem to be reached by 2030 by means of achieving intradomiciliary transmission interruption (IDTI), blood transfusion and transplant transmission interruption, diagnostic and treatment scaling-up and prevention and control of congenital transmission. The NTD Modelling Consortium has developed mathematical models to study Trypanosoma cruzi transmission dynamics and the potential impact of control measures. Modelling insights have shown that IDTI is feasible in areas with sustained vector control programmes and no presence of native triatomine vector populations. However, IDTI in areas with native vectors it is not feasible in a sustainable manner. Combining vector control with trypanocidal treatment can reduce the timeframes necessary to reach operational thresholds for IDTI (<2% seroprevalence in children aged <5 years), but the most informative age groups for serological monitoring are yet to be identified. Measuring progress towards the 2030 goals will require availability of vector surveillance and seroprevalence data at a fine scale, and a more active surveillance system, as well as a better understanding of the risks of vector re-colonization and disease resurgence after vector control cessation. Also, achieving scaling-up in terms of access to treatment to the expected levels (75%) will require a substantial increase in screening asymptomatic populations, which is anticipated to become very costly as CD prevalence decreases. Further modelling work includes refining and extending mathematical models (including transmission dynamics and statistical frameworks) to predict transmission at a sub-national scale, and developing quantitative tools to inform IDTI certification, post-certification and re-certification protocols. Potential perverse incentives associated with operational thresholds are discussed. These modelling insights aim to inform discussions on the goals and treatment guidelines for CD.
A.1. The archaic biography of Homer
Authors: Kivilo Maarit
Published: September 2019

[No abstract]
B.1. Die Beziehungen der antiken und neulateinischen Hochzeitslieder an der Academia Gustaviana am Beispiel von Laurentius Ludenius
Authors: Kaju Katre
Published: September 2019

[No abstract]
A.5. Notes on the lines 93-94 of the Homeric Hymn to Aphrodite
Authors: Taida Ichiro
Published: September 2019

In the lines 93-94 of the Homeric Hymn to Aphrodite, five goddesses (Artemis, Leto, Aphrodite, Themis and Athene) are enumerated. The reason why the poet of the hymn arranged them in that order has not been made clear yet. The purpose of this paper is to find a solution to this question.
A.6. The Presocratics in the doxographical tradition. Sources, controversies, and current research
Authors: Baltussen Han
Published: September 2019

In this paper I present a synthetic overview of recent and ongoing research in the field of doxography, that is, the study of the nature, transmission and interrelations of sources for ancient Greek philosophy. The latest revisions of the theory of Hermann Diels (Doxographi Graeci 1879) regarding the historiography ought to be known more widely, as they still influence our understanding of the Presocratics and their reception. The scholarly study on the compilations of Greek philosophical views from Hellenistic and later periods has received a major boost by the first of a projected three-volume study by Mansfeld and Runia (1997). Taking their work as a firm basis I also describe my own work in this area and how it can be related to, and fitted into, this trend by outlining how two important sources for the historiography of Greek philosophy, Theophrastus (4th-3rd c. BCE) and Simplicius (early 6th c. AD) stand in a special relation to each other and form an important strand in the doxographical tradition.
A.2. Die Alleinherrschaft des Demoteles auf Samos
Authors: Ryan Francis X.
Published: September 2019

There is now an overwhelming consensus in favor of the view that the monarchy attested for Demoteles on Samos was a tyranny. The key piece of evidence, however, is ambiguous. When interpreted one way, another solution is equally probable, and when interpreted another way, this other solution alone is possible.
A.5. The social and cultural implications of curse tablets [defixiones] in Britain and on the Continent
Authors: Adams Geoff W.
Published: September 2019

The central theme of this study is to analyse the idiosyncratic nature of the Romano-British interpretation of the use of defixiones and various 'prayers for justice'. The prevalence of revenge as a theme within this comparatively isolated Roman province is notable and clearly illustrates the regional interpretation that affected the implementation of this religious tradition. The Romano-British curse tablets were largely reactionary, seeking either justice or revenge for a previous wrong, which in turn affected the motivation that led to their production. This regional interpretation was quite different to their overall use on the continent, but even these examples frequently also exhibit some degree of local interpretation by their issuers.
A.2. Esel und Rinder. Mythologische Paradigmata im Schlußteil der Metamorphosen des Apuleius
Authors: Gärtner Thomas
Published: September 2019

In der vorliegenden Arbeit werden zwei Partien aus den Metamorphosen des Apuleius näher betrachtet, in denen eine Verbindung zwischen "Eseln und Rindern" hergestellt wird: An der ersten Stelle wird der sodomistische Geschlechtsverkehr des vereselten Lucius mit einer menschlichen Frau explizit in Verbindung gebracht mit der mythischen Pasiphae-Geschichte; an der zweiten scheint eine bislang verkannte strukturelle Parallele zwischen Lucius und der ovidischen Isis-Erzählung vorzuliegen. An den beiden behandelten Beispielen lässt sich paradigmatisch das weite Spektrum intertextueller Berührung zwischen offen ausgesprochenem Vergleich und verdeckter sinntragender Anpielung erkennen.
A.3. What could Marcus Aurelius feel for Fronto?
Authors: Laes Christian
Published: September 2019

Were Marcus Aurelius and Fronto in love? Does the correspondence between master Fronto and prince Marcus Aurelius prove that their relationship was a fully sexual one? Were both lovers playing dangerous games? This article explores the various possibilities in a relationship which may at first sight seem like a relationship of sexual passion. Contrary to the Amy Richlin thesis, I will contend that it is not justified to interpret the letters as a correspondence between a gay master and his beloved pupil. Taking a closer look at both the literary and the socio-cultural context, one comes to understand what we can and what we cannot know about language games and bodily games of sex in antiquity.
A.3. Textkritische Überlegungen zum Corpus der Seneca-Tragödien
Authors: Gärtner Thomas
Published: September 2019

Kritisch-exegetische Überlegungen auf der Grundlage des aktuellen Forschungsstands zu folgenden Partien aus dem Corpus der Seneca-Tragödien: Herc. 19–21; 21–26; 104–109; 116–122; 1179–1182; 1194–1198; 1229–1236; 1336–1341; Tro. 22–27; 51–56; 59–62; 178–181; 301–305; 365–370; 412–415; 757–759; 799–806; 917–924; 981–998; 1152–1154; Phoen. 22–26; 173–176; 354–362; 434–442; 480–483; Med. 134–136; 447–453; 465–476; 515–519; 777 f.; 954–957; Phaed. 687–693; 1207–1210; Oed. 233–238; 384–389; 957–962; 1014–1018; 1024–1031; Ag. 193–202; 207–219; 544–556; 659–663; 1001–1003; Thy. 13–20; 40–48; 56–62; 267–275; 1096–1102; HO 207–218; 380–390; 719–721; 860–862; 900–902; 929–931; 948–958; 1245–1247; 1456–1466; 1518–1527; 1607–1617; Oct. 45–50; 100 f.; 498–502; 636–643; 717–723; 952–957; 963–968.
A.2. The book-bound scholar
Authors: Beagon Mary
Published: September 2019

This paper takes as its starting point Geoffrey Lloyd's comment that the sources for Pliny's Natural History are 'overwhelmingly literary'. While the encyclopaedic nature of his project might seem to make this inevitable, it is suggested that there are deeper‐seated reasons for Pliny's approach to be found in the attitudes of Rome's cultural élite in the late Republic and early Empire. For this élite, literary culture reflected the socio‐political dynamics of their society, while practical investigations of nature, on the other hand, may for the most part have been associated with the negation of these values. The contrast should not be over‐emphasised: texts on practical subjects could use and exploit empirical evidence and one or two individual enthusiasts may be tentatively posited. However, the breadth and depth of the literary tradition gave the text an authority denied to the particularities of personal experience.
A.3. Leosthenes and the transportation of Greek mercenaries from Asia Minor
Authors: Walsh John
Published: September 2019

Leosthenes is remembered for his heroic death at Lamia, but an earlier part of his career also deserves closer scrutiny. This paper analyzes Leosthenes’ alleged role in transporting a number of mercenaries from Asia to Greece in the prelude to the Lamian war. A re‐assessment of Leosthenes’ actions suggests that his role in this event is grossly exaggerated and should be ascribed to the panegyrical elements that entered the historical tradition after his death. In addition, the thesis of O. Schmitt that Leosthenes transported the mercenaries from Asia on the orders of Alexander the Great has little to recommend it.
Evaluation of DNA damage by Comet Assay in populations of endemic Beyşehir frog Pelophylax caralitanus (Arıkan,1988)
Authors: Erişmiş Uğur Cengiz
Published: September 2019

In study this, the level of DNA damage in three populations of endemic Beyşehir frog (Pelophylax caralitanus) inhabiting on Lakes of Karamık, Eber and Beyşehir with different anthropogenic pollution was assessed by using the DNA Comet Assay technique. Frog erythrocytes cells were used for the analysis. Seven adult individuals were collected from each biotope containing minimum 100 cells were analysed. While the results showing a significant increase in the DNA comet index in the contaminated zone [(Eber Lake= Idc=0.22±0.015), (p<0.05)], the majority of the cells did not contain any DNA damage in the clean zone (Karamık Lake, Idc=0.08±0.001). The obtained data demonstrated t that the endemic Beyşehir frog could serve as a useful flag species in an indicator of anthropogenic impact on ecosystems.
Detection of feeding dietary Rhizostoma pulmo (Macri, 1778) in Samsun coasts of the Black Sea, Turkey
Authors: Dönmez Memet Ali , Bat Levent
Published: September 2019

In this study, gastric contents of the medusa Rhizostoma pulmo distributed along the Samsun coast of the Black Sea were investigated between August 2008 and January 2010. Moreover, the relationship between the umbrella diameter and prey selectivity was determined. Captured R. pulmo individuals during the sampling period varied from 14.5 to 42.5 cm in umbrella diameter. The largest umbrella diameter was observed in October in both periods of the present study. Gastric contents of total 231 R. pulmo individuals have been gathered during the sampling period from all stations. 31 taxa, 10 larvae, 2 nauplii and fish and Copepod eggs from 11 phyla have been identified in the gastric contents of R. pulmo individuals. It has been detected that, feeding choices of R. pulmo individuals have differentiated and their food count has increased due to increasing umbrella diameter (according to Spearman rank correlation, r=0.70; p<0.05). According to the gastric content analyses, the feeding dietary of this species predominantly consists of copepods and dinoflagellates. It has been observed that taxa belonging to Crustaceans (59 %; Copepods 45.9 %) and Dinoflagellates (15.4 %) were densely present in the gastric contents gathered from R. pulmo individuals. The Phylum Ciliophora was another abundantly observed group in the gastric content of R. pulmo, with a 7.2 % representation rate. It was determined that jellyfish have a wide range of nutrition from phytoplankton to fish eggs. The sort of prey and amount of nutrition in stomach contents increased in parallel with the umbrella size. It is concluded that R. pulmo has important effects on the pelagic zone of the Black Sea ecosystem.
Nutritive value and safety aspects of acidified mantis shrimp during ambient storage
Authors: Özyurt Gülsün , Özyurt Caner Enver , Aksun Tümerkan Elif Tuğçe , Özkütük Ali Serhat
Published: September 2019

In this study effects of acidification with an organic acid (3 %, formic acid - FA) and an organic-inorganic acid mixture (1.5 % FA + 1.5 % sulphuric acid - FASA) were evaluated on a non-target species (mantis shrimp - Erugosquilla massavensis). Nutritional composition (proximate analysis and fatty acid composition), chemical (biogenic amine concentrations, non-protein nitrogen -NPN and pH) and microbiological assessments (total viable counts -TVC and lactic acid bacteria counts -LAB) were conducted under 27-28 °C. The analysis conducted for a 60 day period at 1st, 7th, 14th, 30th, 42n﻿d and 60th day intervals. Moisture contents of acidified shrimp were significantly lower than the raw material. No changes in protein contents and an increase in lipid content only in FASA group were observed. Palmitic acid, stearic acid, palmitoleic acid, oleic acid and docosahexaenoic acid (DHA) were observed to be the dominant fatty acids in raw and acidified mantis shrimp. The initial pH value of mantis shrimp was 7.71 and became stable (4.14-3.97) throughout the storage period. An increase was observed in NPN contents and FA and FASA were 0.56 and 0.51 g 100 g-1, respectively at the end of the storage. Putrescine (3.00 mg 100 g-1), tyramine (2.94 mg 100 g-1) and serotonin (2.71 mg 100 g-1) were found to be the dominant biogenic amines in raw mantis shrimp. No significant changes in biogenic amine concentrations were observed in general during the storage period. TVC was found as 4.16 log cfu g-1 at the beginning of the storage period. Bacterial load was decreased after the addition of acids and stayed low throughout the storage period. Increases were observed in LAB and this value were 4.50 and 5.68 log cfu g-1 for FA and FASA group, respectively at the end of the storage period. The results showed acid treated mantis shrimp could be considered potential feed component due to its high nutritional value and safe in regards of biogenic amines.
Comparative Diplectanum aequans (Monogenea) infestations in cultured European seabass (Dicentrarchus labrax) in the Black Sea and the Aegean Sea
Authors: Özer Ahmet , Okkay Sevilay , Öztürk Türkay , Baki Birol , Acar Gökçe , Güven Arzu , Öztürk Dilara Kaya
Published: September 2019

In the present study, monogenean infestations were investigated on the gills of the European seabass Dicentrarchus labrax grown in culture cages located at Yakakent coast of the Black Sea and Milas coast of the Aegean Sea. Parasitological investigations were conducted simultaneously at both localities during September 2014, February and April 2015. While a total of 100 fish specimens were examined from Yakakent samples whose average length was 19.37 cm, a total of 88 fish specimens were examined from Milas samples whose length was 22.67 cm in average. Only one monogenean species Diplectanum aequans was recovered from investigated fish specimens at both sampling localities. Infestation prevalence (%) and mean intensity values of D. aequans were 89.0% and 9.6 ± 0.8 in Yakakent samples while those infestation indices were 90.9% and 13.3 ± 1.2 in Milas samples, respectively. The difference between the infestation prevalence (%) values of D. aequans at both sampling localities was not statistically significant, on the other hand, the difference was statistically significant in the mean intensity values at both locations. Diplectanum aequans showed a homogeneous distribution in all gill arches of fish without any statistically significant difference. This is the first comparative study on the infestation of D. aequans on the gills of European sea bass D. labrax cultured in the Black Sea and the Aegean Sea.