bluuebunny/crossref_metadata_2025 huggingface dataset:
TRANSFERENCIAS ECONOMICAS Y SU IMPACTO EN LA POBREZA DE LOS DISTRITOS MINEROS EN PERU
Authors: Arizaca Avalos Americo , Tumy Gomez Enmanuel , Huisa Mamani Fidel , Arizaca Torreblanca Abelardo , Llanque Maquera Oscar
Published: October 2023

Las transferencias económicas generadas por la explotación de minerales han sido objeto de debate en relación con su impacto en el desarrollo y la reducción de la pobreza, algunas regiones reciben cantidades significativas de dinero, sin embargo, aún no han logrado mejorar sus indicadores de desarrollo. Objetivo: El estudio analiza la repercusión que tienen los fondos de canon, regalías mineras y otras transferencias en la reducción de los indicadores de pobreza de los distritos mineros del Perú. Métodos: se analiza retrospectivamente la distribución del canon y regalías a 1755 distritos del Perú, y se relacionan con los indicadores de desarrollo y pobreza con Rstudio, para el pronóstico se ha utilizado redes neuronales incorporando las transferencias por Foncomun y vaso de leche. Resultados: En la distribución solo 25 distritos superan los 20 millones convirtiéndose en un grupo privilegiado, así mismo se ha establecido, que no existe una relación entre las transferencias por canon y regalías con los indicadores de pobreza y desarrollo humano, en cambio los recursos por Foncomun y vaso de leche tienen mejor asociación variando entre 0,31 y 0,34 respectivamente para el año 2017; Conclusión: Habiendo aplicado redes neuronales se demuestra que los fondos de la actividad minera aportan muy poco al desarrollo humano y a la reducción de la pobreza, contrariamente a los otras transferencias, implicancia que debe ser replanteada en la distribución y el gasto.
A DISTRIBUIÇÃO SOCIAL DO FATURAMENTO AGRO NA REGIÃO METROPOLITANA DE CURITIBA: UMA PERSPECTIVA MULTINÍVEL
Authors: Soares Kleberson Toldo
Published: October 2023

As relações estabelecidas pela construção da identidade agrícola brasileira permeiam o modo de produção e transformam o meio em que atuam, fazendo assim a urgência de modelos de gestão pública que relacionem-se com o atual momento da humanidade e construam caminhos para o futuro. A comunidade agrícola brasileira contempla variadas manifestações culturais com moradores que se adaptam à uma identidade nacional, fomentada por instituições formais e informais, entre elas as políticas públicas e os discursos ideológicos. Mudanças nos processos agrícolas são necessários por diversos motivos que vão desde um mercado consumidor cada vez mais exigente e que preza pela soberania alimentar, à conscientização da necessidade do equilíbrio e proteção dos biomas. Através da metodologia CRISP DM, que utiliza estatística e matemática como base para cruzamento de dados e aqui aplicada aos métodos de pesquisa das Ciências Sociais, o seguinte estudo tem como objetivo criar um modelo inteligente de arquitetura de dados capaz de verificar e acompanhar o impacto do agronegócio na região metropolitana de Curitiba utilizando como amostra um grupo de 143 produtores constatados como os maiores faturamentos. Relacionando os índices econômicos, sociais e ambientais apresentados em uma perspectiva multidimensional, os resultados mostraram que a distribuição social nos municípios, analisados pela ótica do faturamento dos produtores rurais aqui definidos como agricultura empresarial, não está sendo positiva, trazendo a reflexão de uma revisão urgente na formalização da mão de obra do setor assim como na estratégia de política agrícola adotada pelos municípios para direcionar o desenvolvimento econômico e sustentável.
SISTEMAS AGROFLORESTAIS AGROECOLÓGICOS: EXPERIÊNCIAS NO CONTEXTO AMAZÔNICO DO NORDESTE PARAENSE
Authors: Ramos Pinto Sandolene do Socorro , Medeiros Monique
Published: October 2023

RESUMOObjetivo: Este artigo tem como objetivo analisar experiências com sistemas agroflorestais e quintais agroflorestais, com foco na produção e no sistema organizacional a partir de abordagens sobre agroecologia e a produção de novidades, no Nordeste paraense. Métodos: como instrumentos metodológicos foram realizadas entrevistas não diretivas e informais, caminhadas transversais e observações, entre os anos de 2014, 2019 e 2023. Participaram da pesquisa duas famílias de agricultores familiares, uma do município de Baião e outra de São Domingos do Capim. Resultados: as análises realizadas, à luz do enfoque agroecológico de transição para uma agricultura sustentável e da abordagem da Produção de Novidades (Novelty Production), indicam que essas famílias de agricultores, ao construírem tais sistemas agroflorestais, pautados na troca de conhecimentos, na coprodução sociedade-natureza, e no ajuste de práticas e técnicas, os configuram como novidades. Conclusão: melhorias nas condições de vida com segurança alimentar e nutricional, conservação da biodiversidade local e geração de renda.
DESIGNING AT THE SERVICE OF RURAL TERRITORY
Authors: Reyes Iris Andrea , Cifuentes Avendaño Daniela
Published: October 2023

This article provides the results for the project developed to obtain the title as Industrial Designers of the National University of Colombia in Bogotá.As designers we have found an opportunity to solve Service Design issues related to food waste while working hand in hand with the Archdiocesan Food Bank of Bogotá, founded eighteen years ago with the aim to join the academy thus private and public sector, with non-profit organisations that serve to vulnerable populations by collecting, selecting and distributing food, goods and services, either donated or purchased. As a result for this project we have developed ideas of improvement to be implemented on the actual service of PREA (“Programa de Recolección de Excedentes Agrícolas”, Agricultural Surpluses Pickup Program) one of the many programs carried out by the Food Bank.
ESTUDO DE CASO: GESTÃO DA CADEIA DE SUPRIMENTO EMPRESA AMAGGI
Authors: Buquer Enzo , Backes Lucas
Published: October 2023

A gestão eficiente da logística desempenha um papel fundamental na competitividade das empresas do setor agrícola, como é o caso da Amaggi, uma das maiores empresas de agronegócio do Brasil, com especialização na produção e comercialização de commodities agrícolas, incluindo o algodão. O presente resumo acadêmico tem como objetivo fornecer uma visão geral da gestão de logística da Amaggi, com enfoque específico no fluxo de algodão. A Amaggi reconhece a importância estratégica da logística para o sucesso de suas operações no setor do algodão. A empresa implementa um conjunto de práticas e processos logísticos eficientes para otimizar o fluxo de algodão desde a produção até a entrega aos clientes finais. A gestão de logística da Amaggi baseia-se em três pilares principais: planejamento, execução e monitoramento. A Amaggi tem obtido sucesso na gestão de logística, garantindo a entrega eficiente e oportuna do produto aos clientes. A empresa investe constantemente em tecnologia, infraestrutura e capacitação de seus colaboradores para aprimorar sua gestão logística. A eficiência logística da Amaggi contribui para a sua competitividade no mercado agrícola, permitindo que a empresa atenda às demandas dos clientes e aproveite as oportunidades de negócios.
ДЖЕРЕЛЬНА БАЗА ДОСЛІДЖЕННЯ ПРОБЛЕМИ ВИХОВАННЯ УЧНІВСЬКОЇ МОЛОДІ В ЗАКЛАДАХ ПРОФЕСІЙНО-ТЕХНІЧНОЇ ОСВІТИ УКРАЇНИ В 1958-1991 РР.
Authors: Пислар А.Б.
Published: October 2023

У статті проаналізовано джерельну базу дослідження проблеми виховання учнівської молоді в закладах професійно-технічної освіти України впродовж 1958–1991 рр. Автором зазначено, що джерельна база виховання учнівської молоді в закладах професійно-технічної освіти 1958-1991 рр. охоплює широкий комплекс історико-педагогічних джерел, зокрема, інформаційні матеріали, спогади, публіцистичні та наукові твори, архівні відомості та записки, монографії, дисертації тощо. Наголошено на необхідності критичного аналізу джерел для уникнення однобічної інтерпретації подій і фактів, окреслення межнаукової дискусії, уведення до нього контраверсійних питань, визначення бази дослідження. На основі порівняльного аналізу історико-педагогічних праць з цієї проблематики (О. Данилової, М. Гончара, Ю. Кузьменко, В. Кульчицького, О. Петренко, Н. Слюсаренко та ін.) виокремлено авторську класифікацію джерельної бази дослідження проблеми виховання учнівської молоді в закладах професійно-технічної освіти 1958-1991 рр., яка містить такі групи: нормативно-правові джерела, які регулювали діяльність професійно-технічних закладів освіти, зокрема виховну складову, впродовж досліджуваного періоду; архівні джерела; періодичні видання; наративні джерела, які умовно можна поділити на дві підгрупи: опубліковані в радянську добу та видруковані після здобуття Україною незалежності; електронні інформаційні ресурси (оцифровані варіанти опублікованих джерел досліджуваного періоду та сучасні, рукописи). Зроблено висновок, що з другої половини ХХ століття більше уваги було приділено проблемі розвитку професійно-технічної освіти, а також вихованню учнівської молодів у цих закладах. Це, у свою чергу, знайшло своє віддзеркалення в значній кількості історико-педагогічних досліджень, монографіях, навчально-методичних посібниках, наукових та науково-методичних статтях тощо.
Detection and Characterization of Active Microbial Cells in Salt Cavern Brine
Authors: Schwab Laura
Published: October 2023

Salt caverns have been used for decades as natural gas storage facilities and are now target of large-scale underground H2 storage to secure national energy transition goals. Contrary to CH4, H2 is a universal electron donor for microbial anaerobic respiration. Suitable electron acceptors are sulfate and carbonate, which dissolve from gypsum, anhydrite and lime that can make up 10 % of subsurface salt formations. Whilst sulfate reduction is inherently linked to the formation of H2S, microbial CO2 reduction can generate acetate, which can be used as carbon source by diverse microorganisms. Thus, supporting other microbial side effects, such as H2S formation, clogging and H2 consumption. However, microbial diversity and activity in salt caverns are selectively controlled by salt concentrations close to saturation and limited availability of organic carbon. If these conditions allow for microbial activity was investigated in our study.

To circumvent long enrichment times associated with high salinity and limited nutrient availability, we used a stable isotope labelling approach combined with nano-scale secondary ion mass spectrometry analysis (SIP-nanoSIMS) to investigate H2-dependant microbial activity in two brine samples and compared them with that of an extremely halophilic enrichment culture (MP-32). Heavy carbonate and water (13CO2 and 2H2O) served as tracers for microbial activity. Microbial H2 consumption was additionally investigated in microcosm experiments with brine and rock salt over a period of 200 days. Setups with MP-32 served as a positive control. Subsequently, MP-32 was selected for metagenome sequencing to explore potential metabolic pathways and strategies for osmoadaptation.

Analysis of the microbial community composition in brine revealed that members of the Desulfohalobiaceae, Halobacteria and Halanaerobiales were present in all caverns and their relative abundance increased during incubation with H2 as electron donor although sulfate reduction was not observed. But incubation with H2 resulted in an increased uptake of 13C from 13CO2 in 1.6 to 3.6 % of the cells compared to incubations without H2. Uptake of 2H from 2H2O was detected in 20 to 30 % of the cells and was higher when H2 was not offered as an electron donor. Similar results were obtained from the enrichment culture MP-32, which was grown in medium with reduced salinity compared to the salt cavern brine. Uptake of 13C was 10-fold higher when incubated with H2 and nearly all cells incorporated 2H with and without H2. A total of eight metagenome-assembled genomes (MAGs) with a completion of more than 90 % could be recovered from MP-32. Two of them belonged to Desulfohalobiaceae and can be characterized as autotrophic sulfate reducers by means of the Acetyl-Coenzyme A pathway that compensate osmotic stress by synthesizing small organic molecules. Collectively, our findings provide a new approach to study microbial activity that is strongly impacted by high salinity and an improved understanding of their genomic potential.
Impact of hepatitis B virus infection on the risk of gallbladder polyps: a cohort study
Authors: Kim Nam Hee , Kim Hong Joo , Kang Ji Hun
Published: October 2023

Background/Aims: We aimed to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) infection remains an important risk factor for gallbladder polyps (GBPs) in the current context of reduced prevalence of these infections.Methods: The cohort included 392,913 asymptomatic adults who underwent abdominal ultrasonography (US).Results: The prevalence of GBP sized ≥ 5 mm, ≥ 10 mm, and overall (< 5, 5–9 and ≥ 10 mm) was 2.9%, 0.1%, and 12.8%, respectively. The prevalence of hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), and hepatitis C antibody (anti-HCV) positivity was 3.2%, 26.7%, and 0.1%, respectively. The GBP risk was significantly increased in HBsAg-positive individuals, with an adjusted odds ratio of 1.66 (95% confidence interval, 1.49–1.85) for GBP ≥ 5 mm, 2.39 (1.53–3.75) for GBP ≥ 10 mm, and 1.49 (1.41–1.59) for overall, whereas there was no significant association between anti-HCV positivity and GBP risk. The GBP risk did not increase significantly in individuals who tested negative for HBsAg but positive for HBcAb.Conclusions: The presence of HBsAg may be an independent risk factor for GBP development in the current context of a indecreasing prevalence of HBsAg positivity. A more comprehensive evaluation of GBP during abdominal US surveillance of HBsAg-positive individuals may be necessary.
Nodrizas y pedagogos: el saber del hogar en la Atenas democrática
Authors: Valderrábano González Irune
Published: October 2023

Nourrices et pédagogues sont présents dans l’éducation et l’enseignement de la Grèce antique. Ces esclaves anonymes soignaient et accompagnaient leurs maîtres de l’enfance à l’âge adulte, intervenant dans leur formation morale grâce à leur enseignement de la tradition populaire. Le savoir qu’ils possédaient, sa transmission à domicile et l’évolution de leur rôle au cours de l’Antiquité grecque font l’objet de cette étude, pour laquelle nous utiliserons comme sources principales la tragédie classique et les écrits platoniciens sur l’éducation nouvelle.
Les lieux de l’homme qui savait tout. Hippias et la topologie comparée des savoirs selon Platon
Authors: Macé Arnaud
Published: October 2023

L’étude de cas du personnage d’Hippias sert à tester une hypothèse sur le fait que Platon accorde une signification épistémologique à la localisation des différentes figures de savoir qu’il met en scène dans ses dialogues. On explore la « topologie » d’Hippias, en réalisant le recueil des lieux où il exerce ses activités, tout particulièrement à travers les indications qu’en donne Platon dans les deux Hippias . On procède ensuite à deux « topologies comparées » : entre les lieux d’Hippias et ceux des présocratiques tels que ce dernier les conçoit ; entre les lieux d’Hippias et ceux de Socrate.
Habiter le ciel et les nuées : lieu et “non-lieu” du savoir philosophique chez Aristophane et Platon
Authors: Mariat Lora
Published: October 2023

La localisation « éthérée » du savoir philosophique est un lieu commun, qui trouve son expression la plus célèbre dans les Nuées d’Aristophane. Mais une analyse des significations et des images associées à ce lieu symbolique permet d’éclairer les débats qui ont accompagné le développement de ce savoir et les raisons qui ont pu pousser un auteur comme Platon à retourner, à son profit, la caricature du philosophe « les pieds en l’air ».
Une armée de Terre de combat
Authors: Schill Pierre
Published: October 2023

Le contexte stratégique en pleine mutation oblige l’armée de Terre à accélérer sa transformation avec un objectif : être prête à assumer le combat, au service d’une France « puissance d’équilibres et d’entraînement ». Cela exige de renforcer ses capacités opérationnelles en s’appuyant sur ses forces morales, de nouveaux équipements et une réactivité accrue à tous les niveaux.
La France en Indo-Pacifique : une ambition partagée pour une légitimité renforcée
Authors: Genetet Anne
Published: October 2023

La France est présente en Indo-Pacifique et affirme sa volonté d’y être un acteur crédible et respecté, recherchant à rassembler plutôt qu’à diviser. La LPM 2024-2030 renforce les ambitions nationales avec nos partenaires dans une perspective d’équilibre nécessaire au développement économique indispensable pour la région.
Quelle place pour du low cost dans la LPM ?
Authors: Jaouen Alain
Published: October 2023

Les produits low cost envahissent les marchés domestiques et touchent de nombreux secteurs d’activité. La Défense pourrait bénéficier de certaines de ces pratiques pour répondre à de nouveaux besoins opérationnels. La prochaine LPM devrait ainsi permettre de tels développements, tirant des enseignements notamment de la guerre en Ukraine.
Le rôle de l’ONERA dans la future LPM
Authors: Sainjon Bruno
Published: October 2023

L’ONERA s’inscrit pleinement dans les objectifs de la prochaine LPM en préparant l’avenir. La dissuasion, la haute vitesse, l’Espace et le quantique, autant de domaines où l’expertise de l’ONERA est essentielle pour garantir à nos forces de disposer des outils de supériorité opérationnelle. Cela exige des moyens, mais aussi des compétences scientifiques de haut niveau.
Opérer en environnement multi-milieux/multi-champs : de la théorie à la formation
Authors: Douillet Matthieu
Published: October 2023

Opérer aujourd’hui dans un environnement multi-milieux/multi-champs (M2MC) devient complexe et exige de nouvelles formes de travail pour les états-majors opérationnels. L’École de Guerre participe directement à ces travaux doctrinaux en formant ses stagiaires en particulier grâce à l’exercice Coalition , véritable plateforme d’innovation et d’expérimentation dans le champ tactique.
Ils n’avaient qu’à naître avant ! Désastre environnemental et envie entre générations
Authors: Vidaillet Bénédicte
Published: October 2023

En 1972, dans un texte précurseur où il s’étonnait que la crise écologique préoccupe aussi peu ses concitoyens, le psychanalyste américain Harold Searles, inversant le sens dans lequel est habituellement comprise la rivalité œdipienne entre enfants et parents, accordait une place essentielle à l’envie. Il avançait que les parents peuvent entretenir à l’égard de leurs descendants une envie féroce, et les vivre comme des rivaux risquant de les priver de ce qu’ils détiennent – leur mode de vie, leurs privilèges, leurs petits plaisirs, leur pouvoir –, de devenir « rois » à leur place, de les tuer symboliquement. Il se demandait si cette envie n’était pas à l’origine de l’incapacité de ses contemporains à se soucier de l’avenir des générations à venir, voire d’un désir, inconscient et particulièrement tabou, de saboter leurs conditions de vie futures. Cinquante ans après, cette hypothèse reste plus que jamais d’actualité…
Jules, « C’est pas facile »
Authors: Nechaf Mohamed
Published: October 2023

Jules, 16 ans, est coincé à la fois dans une relation de proximité intense à la mère et dans une relation au jumeau où le frère, le rival, devient un « miroir », un double. Dans le huis clos familial à quatre, c’est la mère qui régule les tensions. Le père, travailleur de nuit, n’est, dans la parole de l’adolescent, que le dormeur, une absence sur fond de présence. Comment dès lors se séparer psychiquement de l’Autre primordial ? Quel rôle joue l’institution, où Jules trouve une certaine sérénité relationnelle ?
Jacques Maritain et la fécondité sociale de la sainteté
Authors: Azaïs Augustin
Published: October 2023

Depuis sa conversion avec son épouse dans sa jeunesse, Maritain poursuit le désir d’une authentique vie chrétienne, habitée par l’appel universel à la sainteté. Ce thème de la sainteté ne traverse pas seulement son existence mais aussi son œuvre philosophique, aux frontières de la théologie. En philosophie politique, sa compréhension du temporel et du spirituel s’éclaire lorsqu’on saisit l’importance qu’elle accorde au thème de la sainteté. Comment les saints participent-ils à l’édification d’une société plus juste et plus fraternelle ? Quelle fécondité les saints portent-ils dans la société ? Assez paradoxalement, c’est dans sa discussion avec son ancien maître, Henri Bergson, dont il s’est ensuite vivement éloigné, que l’on perçoit les enjeux de la fécondité sociale de la sainteté.
Société industrielle, management et déconstruction : une tentative d’articulation
Authors: Rappin Baptiste
Published: October 2023

La déconstruction est généralement considérée comme une pensée anticapitaliste. À rebours, cette étude souhaite analyser de façon approfondie les rapports entre déconstruction et société industrielle. Dans un premier temps, après avoir exposé les définitions du management scientifique et de la déconstruction, nous envisageons leur convergence sous deux angles : celui des effets et celui de l’origine. Dans un second temps, nous élargissons le spectre de l’analyse en identifiant et décrivant le rôle anthropologique de la déconstruction au sein de la société industrielle. D’une part, les auteurs de la déconstruction critiquent les analogies de la métaphysique qui reproduisent l’imaginaire néolithique : tel est plus particulièrement le cas de la métaphore de l’arbre ; d’autre part, ils promeuvent une pensée qui fait écho, et même légitime, la structure réticulaire de la société industrielle.
Voir apparaître. L’enjeu de l’ ôphthè pour l’apparaître de la figure chez Hans Urs von Balthasar
Authors: Picard Jocelyne
Published: October 2023

Le ravissement suscité par le voir et l’ ôphthè trouve son fondement dans le Ressuscité luimême apparaissant au matin de Pâques. À partir de l’ ôphthè , Balthasar opère le dépassement sensoriel du voir par le fait qu’en apparaissant, Jésus-Christ « se montre de lui-même  ». Dès lors, la catégorialité de la manifestation est transcendée par ce voir et par un principe de réciprocité, « voir » et « être regardé ». Cette réciprocité est interne à la figure et la détermine comme centre et comme déploiement.
Migrations et pratiques cultuelles. Sur la présence des divinités d’Atfih dans la région du Fayoum à l’époque ptolémaïque
Authors: Cassier Charlène
Published: October 2023

Durant l’époque ptolémaïque, les divinités du nome Aphroditopolite, Hathor maîtresse d’Atfih et Harmotès, apparaissent fréquemment dans la documentation grecque et démotique provenant du Fayoum. Cette documentation semble particulièrement liée à deux localités : Philadelphie, dans la méris d’Hérakleides, et Per-nebet-tepihou/Aphroditopolis, dans la méris de Polémon. Cet article discute des liens religieux qui existent entre le nome Aphroditopolite et ces deux localités du Fayoum, et notamment des établissements de lieux de culte dans un contexte de migration professionnelle. La question d’une vache sacrée, Hésat, morte en dehors de son nome est aussi abordée.
Characterisation of Patients with SH3TC2 Associated Neuropathy in an Indian Cohort
Authors: Nagappa Madhu , Sharma Shivani , Govindaraj Periyasamy , Chickabasaviah Yasha T , Siram Ramesh , Shroti Akhilesh , Seshagiri Doniparthi V , Debnath Monojit , Sinha Sanjib , Bindu Parayil S , Taly Arun B
Published: October 2023

Background:

SH3TC2 variations lead to demyelinating recessive Charcot-Marie-Tooth (CMT) disease, which is commonly associated with early-onset scoliosis and cranial neuropathy. Data from Indian ethnicity is limited.

Objective:

We aim to report the characteristics of patients with SH3TC2-associated neuropathy from an Indian cohort.

Patients and Methods:

Data of five unrelated subjects with SH3TC2 variations were analyzed.

Results:

Clinical features included female predominance (n = 4), early-onset neuropathy (n = 2), pes cavus and hammer toes (n = 4), kyphoscoliosis (n = 1), impaired vision and hearing (n = 1), facial muscle weakness (n = 1), impaired kinaesthetic sense (n = 3), tremor (n = 2), and ataxia (n = 1). Four patients had the “CMT” phenotype, while one patient had Roussy–Levy syndrome. All had demyelinating electrophysiology with conduction velocities being “very slow” in one, “slow” in one, “mildly slow” in two, and “intermediate” in one patient. Brain stem auditory evoked potentials were universally abnormal though only one patient had symptomatic deafness. Seven variants were identified in SH3TC2 [homozygous = 3 (c.1412del, c.69del, c.3152G>A), heterozygous = 4 (c.1105C>T, c.3511C>T, c.2028G>C, c.254A>T)]. Except for c.3511C>T variant, the rest were novel. Three patients had additional variations in genes having pathobiological relevance in other CMTs or amyotrophic lateral sclerosis.

Conclusion:

We provide data on a cohort of patients of Indian origin with SH3TC2 variations and highlight differences from other cohorts. Though the majority were not symptomatic for hearing impairment, evoked potentials disclosed abnormalities in all. Further studies are required to establish the functional consequences of novel variants and their interacting molecular partners identified in the present study to strengthen their association with the phenotype.
Status Dystonicus in Subacute Sclerosing Panencephalitis-A Rare Presentation in Emergency
Authors: Harikrishna Ganaraja Valakunja , Chowdary Mundlamuri Ravindranadh , Vengalil Seena , Nalini Atchayaram , Yadav Ravi
Published: October 2023

Dystonia has been described in a few cases with SSPE, but there are only very few reports with status dystonicus and none from South India. Here, we report a six-year-old child presenting with severe dystonic posturing of all four limbs and trunk for 10 days duration following a febrile illness and initially treated elsewhere as viral encephalitis. Scalp EEG showed periodic high-amplitude slow wave discharges. MRI brain showed T2/FLAIR hyperintensity in bilateral frontal, left parietal, and deep white matter, extending across the corpus collosum with diffuse cerebral atrophy. The titer for IgG antibodies to measles virus by ELISA was 1:625, suggestive of SSPE. With medications, dystonia used to subside transiently; however, the patient had worsening of symptoms and showed gradual deterioration.
Primary Dural Acute Lymphoblastic Leukaemia/Lymphoma Masquerading Meningioma
Authors: Garg Sumit , Gude Geethanjali , Chatterjee Debajyoti , Tewari Manoj K , Singla Raghav , Ahuja Chirag
Published: October 2023

Acute lymphoblastic leukaemia/lymphoma (ALL) is a systemic disease which primarily involves bone marrow or lymphoid organs. Extranodal presentation of ALL is uncommon, and ALL presenting as a dural mass is exceedingly rare. Here we present a case of primary dural B-cell ALL which was preoperatively diagnosed as meningioma on clinico-radiological grounds. A 27-year-old female patient presented with left hemicranial headache for one month's duration along with progressive vision loss of in both eye and altered behaviour. Contrast enhanced magnetic resonance imaging (CE-MRI) suggest dural based mass with dural tail sign. Histopathological examination of the resected specimen revealed B-cell ALL. Further systemic investigations didn't suggest any peripheral blood, bone marrow or lymph node involvement. To the best of our knowledge, only two cases of primary dural ALL have been reported in the literature so far. This report highlights the diagnostic difficulty in extramedullary precursor lymphoid neoplasm.
Antibacterial effectiveness of diluted preparations of intracanal medicaments used in regenerative endodontic treatment on dentin infected by bacterial biofilm
Authors: Khoshkhounejad Mehrfam , Sharifian Mohammadreza , Assadian Hadi , Afshar Mahsa Sobhi
Published: October 2023

Background:

Conventional drug mixtures used in regenerative endodontic procedures have a toxic effect and no consensus has been reached about their best composition and concentration. Therefore, the aim of this study was to determine minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum biofilm inhibitory concentration (MBIC) of the antimicrobial preparations and to compare their antimicrobial efficacy on bovine dentin infected by Enterococcus faecalis.

Materials and Methods:

For this original ex vivo investigation, prepared concentrations (MIC, MBC, and MBIC) of triple antibiotic paste (TAP), double antibiotic paste (DAP), modified triple antibiotic paste (MTAP)-1, MTAP2, co-amoxiclav, and calcium hydroxide (CH) were added to the prepared bovine dentin blocks (which incubated in E. faecalis suspension previously) and incubated for 3 days. The samples were subsequently prepared for culture and CFU counts. Statistical analysis of data was carried out using one-way analysis of variance and post hoc tests. The statistical power was set at P < 0.05.

Results:

All medicament groups significantly showed an antimicrobial efficacy compared with negative control (without antibiotic) (P < 0.001). TAP, DAP, co-amoxiclav, and CH (at its MBC value) were significantly capable of eliminating E. faecalis biofilm and showed no significant difference in comparison with positive control (complete biofilm removal) (P < 0.05).

Conclusion:

TAP, DAP, co-amoxiclav, and CH (at its MBC value) could effectively eliminate biofilm bacteria on the dentin surface. Antimicrobial efficacy of other medicaments containing cefaclor or clindamycin was limited.
Evaluation effect of color in dental office and dentist's uniform while using two different distraction techniques on injection anxiety of 6–9 years' old children referring to Hamedan Dental School
Authors: Rafatjou Rezvan , Ahmadi Bahar , Farhadian Maryam , Moghadam Niloofar Entezari
Published: October 2023

Background:

The management of children's anxiety in dental offices is still a challenge for the treatment team. The most important factors which affect children's dental anxiety are the clinician-related factors and the physical factors of the dental operatory. Color is an environmental factor whose relationship with the perceptive and emotional factors of children has been reported. On the other hand, distraction is essential factors in a treatment environment that can be used to manage children's anxiety.

Materials and Methods:

In this randomized clinical trial study, from 132 6 to 9 years of age children, 52.3% were male, and 47.7% were female, with a mean age of 7.45 ± 1.1 years. The children's anxiety levels were determined using the Venham Picture Test and pulse oximetry before and after the administration of local anesthesia. The children were randomly assigned to two groups (n = 66): Group 1, music, and Group 2, animated cartoons. The data were analyzed with SPSS 25, using descriptive statistics and the statistical tests consisting of one-way analysis of variance (ANOVA), t-test, and repeated-measures ANOVA, followed by Tukey honestly significant difference tests. Statistical significance was set at P < 0.05.

Results:

The anxiety levels were the lowest in the blue and pink environments and the highest in the black and red. Anxiety levels between different colors in terms of physiologic markers and the questionnaire in each distraction technique at different intervals was significantly different.

Conclusion:

The use of blue, pink, green, and yellow for dentists' attire, and the interior design of the dental operatory decreased the child patients' anxiety.
The effect of ostrich acellular dermal matrix on keratinized gingival width
Authors: Ahmadi Roya Shariatmadar , Inanlou Mahdi , Khoshzaban Ahad , Asghari Ahmad , Akhondi Nasrin , Sayar Ferena
Published: October 2023

Background:

Xenogeneic grafts have gained attention due to advantages in compare of autografts. This study aimed to compare Xeno (ostrich) Acellular Dermal Matrix (XADM) with the free gingival graft (FGG) to increase the width of Keratinized gingiva (KGW) in dogs.

Materials and Methods:

This split mouth animal study was performed on 10 mixed breed dogs. The upper second premolar sites were randomly selected for grafting by XADM (test) or FGG (control). Measurements of KGW were recorded before surgery, 1, 3, and 6 months after surgery. Biopsies from grafted sites for histologic and histomorphometric evaluations were harvested 6 months after surgery. Data were analyzed by repeated measured, paired samples t-test, and Wilcoxon Signed rank test. P < 0.05 was considered statistically significant.

Results:

KGW increased in the two study groups after surgery with no significant statistical difference between them at any time intervals (P > 0.05). The graft shrinkage was 23% and 21% for the test and control groups, respectively, without statistically significant difference (P > 0.05). Histomorphometric evaluation showed no significant difference between the two study groups. Foreign body reaction was not seen in any of the study groups.

Conclusion:

Increased KWG was similar between the two study groups. With regard to FGG limitations, XADM may be assumed as a suitable alternative for FGG. It should be noted that this research was an animal study and clinical trials on human should be performed to approve the efficacy and safety of this material.
Evaluation of the antimicrobial efficacy of different concentrations of a novel root canal filling material for primary teeth - An in vitro study
Authors: Govindaraju Lavanya , Jeevanandan Ganesh
Published: October 2023

Background:

The demand for an ideal root canal filling material in primary teeth with maximum antibacterial properties keeps escalating to improve the success rate of root canal treatment in primary teeth. Hence, the present study was conducted to determine the antimicrobial efficacy of the different concentrations of a novel root canal filling material.

Materials and Methods:

An in vitro study was designed to compare the antimicrobial efficacy of different concentrations of the novel obturating material for primary teeth. Different concentrations of the novel obturating material were prepared using calcium hydroxide, zinc oxide cement, and metronidazole and were tested for its antimicrobial efficacy against Streptococcus mutans and Enterococcus faecalis using Mueller–Hinton Agar for 24 h at 37°C. The zone of inhibition was measured in millimeters after 24 h. The values were entered into a Microsoft Excel spreadsheet and subjected to statistical analysis. Descriptive statistics were used for data summarization and presentation. Friedman test and Kruskal–Wallis test were used to compare the different concentrations of the novel obturating materials against S. mutans and E. faecalis. P < 0.05 was considered to be significant.

Results:

Against S. mutans at 1% concentration, the zone of inhibition was statistically greater at 50 μl and at 2% and 3%, the zone of inhibition was greater at 100 μl. Similarly, against E. faecalis, the zone of inhibition was statistically greater at 100 μl at 2% and no significant difference was noted at 1% and 3%. Comparison between the groups at 25, 50, and 100 μl shows no significant difference against S. mutans between 1%, 2%, and 3% of 60–40 concentration. However, 3% 60–40 concentration at 50 μl shows significantly increased zone of inhibition against E. faecalis.

Conclusion:

Two percentage metronidazole at 60–40 (calcium hydroxide–zinc oxide) concentration of the novel obturating material at 100 μl has better antibacterial properties against both S. mutans and E. faecalis.
Antibacterial activity and shear bond strength of fiber-reinforced composites and bonding agents containing 0.5%, 1%, 2.5%, and 5% silver nanoparticles
Authors: Jenabi Nastaran , Sadeghian Susan , Karimzadeh Fathallah , Pour Maryam S , Rakhshan Vahid
Published: October 2023

Background:

Bonded composites may increase bacterial accumulation and caries formation risk. Therefore, assessment of methods to decrease bacterial activity around them would be valuable. The literature on the efficacy of adding silver nanoparticles to fiber-reinforced composite (FRC) or adding them to bonding agents in terms of their antibacterial activity and/or shear bond strength (SBS) is scarce. Thus, we aimed to assess the antibacterial activity of flowable composites and bonding agents containing various percentages of experimental silver nanoparticles (nanosilver) against S. mutans and to evaluate the SBS of FRC and bonding agents containing different amounts of nanosilver to enamel.

Materials and Methods:

In this preliminary study, 0% (control), 0.5%, 1%, 2.5%, and 5% nanosilver were added to flowable composite and bonding agent. Syntheses of nanosilver and nanosilver-incorporated composite specimens were approved using X-ray diffraction spectroscopy and scanning electron microscopy. Antibacterial effects of the produced materials on S. mutans were evaluated by colony count with serial dilution method (n = 7 groups × 10 [n = 70] specimens) and agar disc diffusion test (n = 6 groups × 5 [n = 30] composite specimens + n = 6 groups × 5 [n = 30] light-cured bonding + n = 6 groups × 5 [n = 30] uncured bonding) against negative control and cefotaxime antibiotic. Moreover, SBS values of various FRC blocks bonded to enamel using various bonding agents were measured (n = 9 groups × 6 [n = 54] human premolars). Data were analyzed using Kruskal–Wallis, Dunn, two-way analysis of variance, and Tukey's tests (α = 0.05).

Results:

Composite discs containing all concentrations of nanosilver reduced S. mutans colony counts (P < 0.05); bacterial growth was ceased at samples containing 2.5% and 5% of nanosilver. The reduction in the SBS of FRCs was significant only for 5% nanosilver (P < 0.05).

Conclusion:

Adding 0.5%, 1%, and 2.5% nanosilver to composite and 0.5% or 1% nanosilver to bonding agent led to a significant antibacterial behavior against S. mutans while not significantly affecting the SBS of FRC.
The advantages of inhalational sedation using an anesthetic-conserving device versus intravenous sedatives in an intensive care unit setting: A systematic review
Authors: Aseri Zohair Al , Alansari Mariam Ali , Al-Shami Sara Ali , Alaskar Bayan , Aljumaiah Dhuha , Elhazmi Alyaa
Published: October 2023

BACKGROUND:

Sedation is fundamental to the management of patients in the intensive care unit (ICU). Its indications in the ICU are vast, including the facilitating of mechanical ventilation, permitting invasive procedures, and managing anxiety and agitation. Inhaled sedation with halogenated agents, such as isoflurane or sevoflurane, is now feasible in ICU patients using dedicated devices/systems. Its use may reduce adverse events and improve ICU outcomes compared to conventional intravenous (IV) sedation in the ICU. This review examined the effectiveness of inhalational sedation using the anesthetic conserving device (ACD) compared to standard IV sedation for adult patients in ICU and highlights the technical aspects of its functioning.

METHODS:

We searched the PubMed, Cochrane Central Register of Controlled Trials, The Cochrane Library, MEDLINE, Web of Science, and Sage Journals databases using the terms “anesthetic conserving device,” “Anaconda,” “sedation” and “intensive care unit” in randomized clinical studies that were performed between 2012 and 2022 and compared volatile sedation using an ACD with IV sedation in terms of time to extubation, duration of mechanical ventilation, and lengths of ICU and hospital stay.

RESULTS:

Nine trials were included. Volatile sedation (sevoflurane or isoflurane) administered through an ACD shortened the awakening time compared to IV sedation (midazolam or propofol).

CONCLUSION:

Compared to IV sedation, volatile sedation administered through an ACD in the ICU shortened the awakening and extubation times, ICU length of stay, and duration of mechanical ventilation. More clinical trials that assess additional clinical outcomes on a large scale are needed.
Fluctuations in Seminal Quality throughout the Year: How do Temperature, Humidity and Atmospheric Pressure Impact on Human Sperm Quality?
Authors: Ramírez Nicolás David , Tissera Andrea , Molina Rosa , Olmedo Jose , Molina Héctor Guillermo , Mangeaud Arnaldo , Martini Ana Carolina
Published: October 2023

Background:

Most studies evaluating the possible seasonal variation of semen quality have considered temperature as the only causal factor.

Aims:

To assess possible seasonality in sperm quality and associations between semen parameters and several meteorological variables (temperature, humidity, apparent temperature and atmospheric pressure) in a large cohort of andrological patients.

Settings and Design:

This was a retrospective, cross-sectional and correlational/descriptive study.

Materials and Methods:

Patients (n: 15665) were categorised into four groups (summer, winter, spring and autumn) according to the date of assistance at the fertility centre. Daily values of temperature, apparent temperature, humidity and atmospheric pressure were provided by the National Weather System and were calculated as the average of the 74 days previous to semen collection (spermatogenic cycle).

Statistical Analysis Used:

As appropriate, the results were analysed by analysis of variance/Kruskal–Wallis, Chi-square test, t-test/Mann–Whitney, forward conditional regression model and Spearman/Pearson’s correlations.

Results:

We detected seasonality effects on sperm count, total sperm count and total motile sperm count, with the highest values in winter and the lowest in summer. Correlation analysis showed that temperature, apparent temperature and humidity negatively correlated with semen parameters, being humidity the most powerful predictive meteorological variable.

Conclusion:

Sperm quality is influenced by seasons; increased environmental temperature and humidity negatively affect semen quality.
Ovarian Stimulation in Patient-oriented Strategies Encompassing Individualised Oocyte Number-4 Category; Antagonist versus Short-agonist Protocols
Authors: Al-Hussaini Tarek K. , Mohamed Ahmed Aboelfadle , Askar Ayman , Abden Ahmed A. , Othman Yousra M. , Hussein Reda S.
Published: October 2023

Background:

Recently POSEIDON (Patient-Oriented Strategies Encompassing Individualized Oocyte Number) classification was proposed to categorize patients with expected poor response to conventional stimulation. Searching for the ideal management of poor responders in IVF is still an active research area.

Aims:

This study compares GnRH-antagonist and GnRH-agonist short protocols in ICSI cycles for the POSEIDON-4 group.

Settings and Design:

This retrospective study was conducted in a tertiary infertility unit between January 2016 and December 2020.

Materials and Methods:

Infertile women who met the criteria for POSEIDON 4 group and underwent fresh ICSI-ET in using GnRH-antagonist and GnRH-agonist short protocols was performed. POSEIDON-4 includes patients ≥ 35 years with poor ovarian reserve markers; AFC < 5 and AMH < 1.2 ng/ml.

Statistical Analysis Used:

Numerical variables were compared between both groups by student’s t test and Mann Whitney test when appropriate. Chi-square test used to compare categorical variables. Multivariate logistic regression models were utilized to adjust for the effect of the different study confounders on live birth rate.

Results:

One hundred ninety fresh ICSI cycles were analyzed. Of the total cohort, 41.6 % (79) patients pursued antagonist protocol compared to 58.4% (111) underwent short agonist protocol. Fresh embryo transfer was accomplished in 55.7 % (44/79) vs. 61.3 % (68/111), P = 0.44 in antagonist vs. short protocol respectively. Cycle cancellation due to poor ovarian response was encountered in (32.9%vs. 27.9%, P = 0.50) in the antagonist and short groups, whereas no good-quality embryos were developed after ovum pickup in 11.4% vs. 10.8%, P>0.05. Comparable total gonadotropins dose, number of retrieved and mature oocytes, and good-quality embryos were found in both groups. Likewise, clinical pregnancy rate was not different for the antagonist and short groups [11/79 (13.9%) vs. 20/111 (18%), P = 0.45]. The live birth rate was comparable between both groups (8.9% vs. 10.8%, P = 0.659) for antagonist and short groups respectively. No significant impact for the protocol type on live birth rate was revealed after adjusting to cycle confounders in multivariate analysis (OR: 0.439, 95%CI 0.134-1.434, P = 0.173).

Conclusion:

This study shows comparable pregnancy outcomes for antagonist and short-agonist protocols in IVF/ICSI cycles for POSEIDON-4 category.
Acceptance of Elective Single-embryo Transfer in a Resource-limited Setting: A Cross-sectional Questionnaire-based Study
Authors: Jayakumar Nithya Panapakkam , Solanki Megha , Karuppusami Reka , Joseph Treasa , Aleyamma Thayparmbil Kunjummen , Kamath Mohan Shashikant
Published: October 2023

Background:

While elective single-embryo transfer (eSET) has been advocated in select countries, the global acceptance of the eSET policy has been undermined due to various issues. It is imperative to understand the couples’ perspectives regarding the number of embryos transferred.

Aims:

We planned a study to evaluate the knowledge and attitude of infertile couples undergoing assisted reproductive technology towards eSET in self-funded treatment cycles in a low-resource setting.

Settings and Design:

We conducted a cross-sectional study at a tertiary-level referral facility between February 2020 and September 2022.

Materials and Methods:

This was an interviewer-administered questionnaire-based survey in two stages. The first stage involved the assessment of the knowledge of the participants. Following this, participants were given an information pamphlet and the second stage of the interview was conducted to assess the attitude and change in preference for embryo transfer number.

Statistical Analysis Used:

The Chi-square and Fisher’s exact test were applied to find an association between categorical variables. Logistic regression was used to assess the association between factors and outcomes.

Results:

eSET was the preferred choice for only 5.8% of the participants. Following our educational intervention using an information leaflet, there was a statistically significant increase in the preference for eSET (P = 0.01). Univariate logistic regression analysis revealed that participants with a monthly income of ≤50,000 INR had a significantly higher preference for eSET.

Conclusion:

Continued emphasis on the risks of double-embryo transfer coupled with individualised selection criteria for eSET may help to achieve reasonable congruency between the clinician and couples’ decision.