bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of fuzzy search method for creating an efficient information search system in text data
Authors: Kleshch Kyrylo
Published: March 2024

The object of research is the processes of effective search for information in a set of textual data. The subject of the research is the fuzzy search method, which will allow to effectively solve the problem of searching for information in a set of textual data. The paper considers the process of developing a fuzzy search method, which consists of 9 consecutive steps and is required for a quick search for matches in a large set of text data. Based on this method, it is proposed to create a fuzzy search system that will solve the problem of finding the most relevant documents from a set of such documents.
The proposed fuzzy search method combines the advantages of algorithms based on deterministic finite automata and algorithms based on dynamic programming for calculating the Damerau-Levenshtein distance. Such a combination allows to implement the symbol similarity table in an optimal way. As part of the work, an approach for creating a symbol similarity table was proposed and an example of such a table was created for symbols from the English alphabet, which allows to find the degree of similarity between two symbols with constant asymptotics and to convert the current symbol into its basic counterpart. For document filtering, a metric was developed to evaluate the correspondence of text data to a search phrase, which simultaneously takes into account the number of found and not found characters and the number of found and not found words.
The Damerau-Levenstein algorithm allows to find the edit distance between two words, taking into account the following types of errors: substitution, addition, deletion, and transposition of characters. The work proposed a modification of this algorithm by using a similarity table to more accurately estimate the editing distance between two words.
The developed method makes it possible to create a fuzzy search system that will help find the desired results faster and increase the relevance of the obtained results by sorting them according to the values of the proposed test data similarity metric.
Research into arsenic (III) effective catalytic oxidation in an aqueous solution on a new active manganese dioxide in a flow column
Authors: Abower Denis
Published: March 2024

Groundwater in many places on Earth contains arsenic compounds. Arsenic (III) compounds must be oxidised to purify water containing arsenic effectively. The subject of this study is oxidation of arsenic (III) compounds in an aqueous solution.
Today’s most common industrial arsenic oxidation method using aggressive oxidising agents such as chlorine or ozone has a number of serious disadvantages. The most problematic of these include extremely high risks to human health and the environment, the cost and overall complexity of the process. Catalytic oxidation of arsenic (III) compounds using atmospheric oxygen is an alternative free from the above disadvantages, yet, to date, no information about effective catalysts for this process has been presented in the literature.
The arsenic (III) catalytic oxidation process is studied in an aqueous solution on a new active manganese dioxide (NAMD) synthesised by the author. A comparative experimental analysis is performed with other known modifications of manganese dioxide. It is shown that the new active manganese dioxide (NAMD) has high catalytic activity towards arsenic (III), this being confirmed experimentally in both a limited volume and a flow column mode. Some theoretical aspects of the mechanism for catalytic oxidation of arsenic (III) with oxygen on active manganese dioxide in an aqueous solution are also discussed on the basis of the research results.
Experimental work is required at pilot plants in the field for successful industrial implementation of the technology for catalytic oxidation of arsenic (III) compounds on NAMD. Further laboratory research is necessary for developing a detailed theoretical basis for catalytic oxidation of arsenic in aqueous solutions.
The results of this research are of interest to industrial companies specialising in removing arsenic compounds from water, to scientists and researchers studying catalytic oxidation of arsenic (III), as well as heterogeneous catalytic oxidation with oxygen in general.
Responsible Research Assessment requires structural more than procedural reforms
Authors: Frischkorn Gidon T.
Published: March 2024

In their target articles, Schönbrodt et al. (2022) and Gärtner et al. (2022) propose new metrics and their practical implementation to improve responsible research assessment. Generally, I welcome the inclusion of open science and scientific rigor into evaluating job candidates. However, the proposed reform mainly focuses on the first stage of selecting candidates who then continue towards a second stage of in-depth evaluation of research quality. Yet, this second selection stage is underdeveloped but likely more critical concerning responsible research assessment and hiring decisions. I argue that an adequate assessment of research quality at this second stage requires the representation of specific knowledge in the subfield of a discipline that the candidate should be hired for by the hiring committee. This is rarely achieved given the current structural organization of departments, especially in German-speaking countries, and potentially explains the reliance on suboptimal indicators such as h-index and Journal Impact factor. Therefore, I argue that responsible research assessment requires structural reform to ensure that institutions have several researchers in permanent positions with specific knowledge in different subfields to provide an adequate and responsible assessment of research quality by hiring committees at all evaluation stages.
Indicators for teaching assessment
Authors: Hansen Miriam , Beitner Julia , Horz Holger , Schultze Martin
Published: March 2024

This commentary on Schönbrodt et al. (2022) and Gärtner et al. (2022) aims at complementing the ideas regarding an implementation of DORA for the domain of teaching. As there is neither a comprehensive assessment system based on empirical data nor a competence model for teaching competencies available, yet, we describe some pragmatic ideas for indicators of good teaching and formulate desiderates for future research programs and validation.
Comment on "Responsible Research Assessment: Implementing DORA for hiring and promotion in psychology”
Authors: Auger Victor , Claes Nele
Published: March 2024

In target papers, Schönbrodt et al. (2022), and Gärtner et al. (2022) proposed to broaden the range of the considered research contributions, namely (i) bringing strong empirical evidence, (ii) building open databases, (iii) building and maintaining packages, where each dimension being scored independently in marking scheme. Using simulations, we show that the current proposal places a significant weight on software development, potentially at the expense of other academic activities – a weight that should be explicit to committees before they make use of the proposed marking scheme. Following Gärtner et al. (2022) recommendations, we promote the use of flexible weights which more closely match an institution’s specific needs by the weighting of the relevant dimensions. We propose a Shinyapp that implement the marking scheme with adaptative weights to both help the hiring committee define and foresee the consequences of weights’ choices and increase the transparency and understandability of the procedure.
Responsible research assessment in the area of quantitative methods research: A comment on Gärtner et al.
Authors: Brandt Holger , Henninger Mirka , Ulitzsch Esther , Kleinke Kristian , Schäfer Thomas
Published: March 2024

In this commentary, we discuss the proposed criteria in Gärtner et al. (2022) for hiring or promoting quantitative methods researchers. We argue that the criteria do not reflect aspects that are relevant to quantitative methods researchers and typical publications they produce. We introduce a new set of criteria that can be used to evaluate the performance of quantitative methods researchers in a more valid fashion. We discuss the necessity to balance scientific expertise and open science commitment in such ranking schemes.
A case-study of using content and language integrated learning methodology in tertiary education course design
Authors: Medvedev Yury , Maykova Tatiana
Published: March 2024

This article examines the principles of Content-Language Integrated Learning (CLIL) as a theoretical basis for a course of English for academic purposes and discusses the results of a pilot project based on a combination of CLIL and Language for Specific Purposes (LSP) methodologies. Although the two methodologies share common features, such as the use of authentic materials or emphasis on students’ needs, they differ on their goals, general approach, and required classroom hours. The CLIL approach is based on a balance between content-centered learning and mastering a foreign language through the content, while LSP is a special form of a foreign language instruction that teaches students how to use it in a particular field of knowledge or line of work.
A pilot course in English for Special Purposes, described here, was developed to prepare students for further full English-language instruction in some of their major disciplines. Due to the limited number of classroom hours and the focus on mastering primarily the language of specialization, the course mainly applies LSP approach in combination with some CLIL techniques and methods, such as guided reading, text markup, visual support, linguistic support, and multimodal input.
The course was run as a pilot project throughout one academic year, weekly in the form of
two-hour English classes, and involved two groups of third-year students majoring in International Relations or Regional Studies with 25 participants in each. In a follow-up survey, the students reported increased motivation, better word retention, improved fluency and better listening comprehension.
BILE DUCT INJURY REPAIR IN A PATIENT WITH SITUS INVERSUS TOTALIS
Authors: MEIRA-JÚNIOR José Donizeti , RAMOS-ARANDA Javier , CARRILLO-VIDALES Javier , VELÁSQUEZ-CORIA Erik Rodrigo , MERCADO Miguel Angel , DOMINGUEZ-ROSADO Ismael
Published: March 2024

ABSTRACT BACKGROUND: Bile duct injury (BDI) causes significant sequelae for the patient in terms of morbidity, mortality, and long-term quality of life, and should be managed in centers with expertise. Anatomical variants may contribute to a higher risk of BDI during cholecystectomy. AIMS: To report a case of bile duct injury in a patient with situs inversus totalis. METHODS: A 42-year-old female patient with a previous history of situs inversus totalis and a BDI was initially operated on simultaneously to the lesion ten years ago by a non-specialized surgeon. She was referred to a specialized center due to recurrent episodes of cholangitis and a cholestatic laboratory pattern. Cholangioresonance revealed a severe anastomotic stricture. Due to her young age and recurrent cholangitis, she was submitted to a redo hepaticojejunostomy with the Hepp-Couinaud technique. To the best of our knowledge, this is the first report of BDI repair in a patient with situs inversus totalis. RESULTS: The previous hepaticojejunostomy was undone and remade with the Hepp-Couinaud technique high in the hilar plate with a wide opening in the hepatic confluence of the bile ducts towards the left hepatic duct. The previous Roux limb was maintained. Postoperative recovery was uneventful, the drain was removed on the seventh post-operative day, and the patient is now asymptomatic, with normal bilirubin and canalicular enzymes, and no further episodes of cholestasis or cholangitis. CONCLUSIONS: Anatomical variants may increase the difficulty of both cholecystectomy and BDI repair. BDI repair should be performed in a specialized center by formal hepato-pancreato-biliary surgeons to assure a safe perioperative management and a good long-term outcome.
PARTIAL DISTAL DUODENECTOMY IN PATIENT WITH ADENOCARCINOMA
Authors: LOSADA Héctor , PORTILLO Norberto , TRONCOSO Andrés , BECKER Renato , VERA Rocio
Published: March 2024

ABSTRACT BACKGROUND: Duodenal adenocarcinoma is a small percentage of gastrointestinal neoplasms, around 0.5%, and its treatment is based on resection of the tumor, classically by pancreaticoduodenectomy. In recent years, however, segmental resections of duodenal lesions, that do not involve the second portion or the periampullary region, have gained relevance with good surgical and oncological outcomes as well as the benefit of avoiding surgeries that can result in high morbidity and mortality. AIMS: To report a case of an elderly female patient with malignant neoplastic lesion in the third and fourth duodenal portion, non-obstructive, submitted to surgical treatment. METHODS: The technical option was the resection of the distal duodenum and proximal jejunum with preservation of the pancreas and reconstruction with side-to-side duodenojejunal anastomosis. RESULTS: The evolution was satisfactory and the surgical margins were free of neoplasia. CONCLUSIONS: Segmental resections of the duodenum are feasible and safe, offering the benefit of preventing complications of pancreaticoduodenectomies.
You Are in the Empire, Friend: The Legacy of the Russian Imperial Narrative in the Poetry of Joseph Brodsky
Authors: Zorattini Júlia
Published: March 2024

ABSTRACT This article aims to investigate the imperial element in the poetry of Joseph Brodsky through the lenses of post-colonial studies. Its ambiguity, informed by Brodsky’s experience as a poet in exile, as well as his personal cultural frame, echoes that of his poetic precursors. Thus, we briefly trace the history of the connection between Russian poetry and the imperial narrative, which began with the inception of the Russian Empire itself in the 18th century. Then, we explore the nuance of the concept of empire in Brodsky’s works through the analysis of the poems Post aetatem nostram (1970), Torso (1972) and On the Independence of Ukraine (1991). As we understand it, both the chauvinistic content of the latter poem and the positive and nostalgic aspect of empire to Brodsky reveal the longevity and the strength of the Russian imperial narrative in the country’s national literature.
Polyphony of Unguided Voices: A Bakhtinian Reading of Hosseini’s The Kite Runner
Authors: Narwani Nisha , Vaidya Manjiree
Published: March 2024

ABSTRACT The Russian philosopher Mikhail Bakhtin had given a variety of concepts to appreciate and analyze a novel. In this study, there is an attempt to apply the Bakhtinian intellectual tool of polyphony to unearth the deeper layers of Khaled Hosseini’s novel The Kite Runner. We argue that the novel is polyphonic through and through since it reverberates with multiple voices of various characters, and the novel’s narrative structure also supports this multiplicity of viewpoints. The novel defies the traditional path of having the final word from the author or the narrator. In many situations, the narrator’s voice struggles and fumbles with confusion, but the voices of some of the characters come up clearly and remain firm on certain aspects. This paper will provide a systematic exposition and an analysis of the novel The Kite Runner from the Bakhtinian lens to appreciate the anti-authorial mode where pluralism (polyphony) is celebrated.
Exu-feminina: sentido e erotismo em Maria Padilha de Bixarte
Authors: Correia Bruna dos Santos
Published: March 2024

RESUMO Nesta pesquisa, de abordagem qualitativa e descritiva, objetiva-se investigar os possíveis efeitos de sentidos vinculados à imagem de Exu-Feminina a partir do dispositivo teórico da Análise do Discurso Materialista. As mitologias em torno desta entidade estão vinculadas a seu poder sobre as encruzilhadas e seu potencial em abrir caminhos e formas de compreender a vida para seus fiéis. Ademais, a imagem da entidade atualiza significações do erotismo. Considerando a hegemonia das ideologias cristãs, a imagem de Exu-Feminina remete a interpretações divergentes daquelas que vinculam o erótico ao pecado. Por isso, ao contrário da ideologia cristã, como a imagem de diabo e/ou satanás, além de aspectos eróticos negativos/pejorativos vinculados à entidade por sujeitos não candomblecistas e umbandistas, a proposta da pesquisa é também investigar possíveis sentidos eróticos na música Maria Padilha de Bixarte.
Cuidado em saúde ao adolescente em vulnerabilidade ao uso de drogas
Authors: Mancilha Grasiella Bueno , Covic Amalia Neide
Published: March 2024

RESUMO Este artigo trata das adolescências, no plural, como construção histórico-social de um processo dinâmico, e do adolescente perante seus modos de vida e expressão em um contexto histórico-social e singular. Entende-se aqui que ações meramente prescritivas são insuficientes para responder às complexidades dos processos de adoecimento mental na sociedade contemporânea. Objetivou-se compreender o contexto das práticas de cuidado em saúde ao adolescente em vulnerabilidade, diante do uso de drogas, na dimensão das tensões dos campos de práticas do cuidado em saúde. Estudo descritivo exploratório de abordagem qualitativa, que realizou entrevistas com profissionais da área da saúde (Unidade Básica de Saúde e Centro de Atenção Psicossocial Infantojuvenil). Destacam-se as tensões no campo de práticas entre o modelo assistencial biomédico e de guerra às drogas versus o psicossocial/comunitário; redução de estigma; acesso; redução de danos e nos atendimentos individuais, bem como a importância de refletir e fomentar o processo de mudança da mentalidade diante do adoecimento mental, visando atualizar as formas de cuidar. Esse processo tem sido realizado conforme os princípios da Reforma Psiquiátrica Brasileira, com avanços e retrocessos que repercutem na atualização das práticas de cuidado em saúde mais alinhadas às propostas de ações psicossociais e redutoras de vulnerabilidade.
Injustiça na resposta internacional à COVID-19: lições a aprender
Authors: Rego Sergio , Palácios Marisa , Matta Gustavo Correa
Published: March 2024

Introdução: A pandemia da Covid-19 surpreendeu até as nações economicamente mais desenvolvidas. A surpresa não foi o surgimento de uma nova pandemia, que já estava no horizonte dos sanitaristas mais atentos, mas a sua intensidade e efeitos em todos os países, mesmo nos mais ricos. Em termos de resposta, embora iniciativas como o Mecanismo COVAX (OMS) tenham sido encorajadas por todos, não foram suficientes para garantir condições minimamente justas para respostas à pandemia em todo o mundo. Objetivo: analisar criticamente a experiência do projeto COVAX Facility como projeto de solidariedade internacional. Discussão: Os efeitos da exploração colonial e neocolonial e da colonialidade preservam as injustiças nas relações políticas e impedem uma distribuição mais justa de recursos para combater a pandemia. Pandemias como a Covid-19 expuseram o carácter explorador da globalização: a circulação de bens, pessoas e serviços em todo o mundo gera um vector de acumulação de capital dirigido aos países centrais, e os seus efeitos, por exemplo, a propagação de doenças infecciosas com elevada infectividade , penalizam ainda mais os países mais pobres. As desigualdades no acesso às vacinas e aos serviços de saúde entre os países são injustas e constituem um terreno fértil para novas cepas virais que podem ser ainda mais transmissíveis e com maior gravidade. Considerações finais: Os determinantes sociais do processo de saúde e doença devem ser considerados no planejamento de respostas às emergências de saúde, tanto localmente como internacional, reconhecendo que a proteção dos cidadãos e das comunidades deve ser reconhecida como um imperativo ético. O Antropoceno é uma realidade, e é necessário cuidar do planeta na totalidade, com ações efetivamente solidárias, em termos da solidariedade reflexiva como sugere Dean, se quisermos evitar o colapso.
REVISITING TINNITUS AUDIOLOGICAL REHABILITATION
Authors: Barros Anna Carolina Marques Perrella de , Onishi Ektor Tsuneo , Suzuki Flávia Alencar de Barros , Branco-Barreiro Fátima Cristina Alves
Published: March 2024

Current research shows tinnitus as more than an auditory phenomenon, but an emotional and cognitive dimension experience. Besides issues involving tinnitus perception and reaction, there is a third dimension: cognition. Both audiological assessment and rehabilitation need to follow these principles and be more comprehensive. The use of sounds to treat tinnitus is described in several papers and has different purposes. It includes hearing aid fitting if hearing loss is detected and the use of sound generator devices. But there are some cases in that hearing loss rehabilitation is not enough and cases of tinnitus and/or sound intolerance suffering without detectable hearing loss in conventional measures. There is no exclusive way for tinnitus patients’ auditory rehabilitation. Based on theoretical proposals and literature, we suggest possibilities of intervention to be even more explored and personally adapted for tinnitus patients: cognitive auditory training and the use of mindfulness-based exercises, sound stimulation during sleep, and restoring the pleasure of listening.
Study of the Financial Crisis in the Countries of the Eurasian Economic Union: Marxist Approach
Authors: Abgaldaev Vladimir , Bubnov Vyacheslav , Osodoeva Olga
Published: March 2024

The financial crisis is a serious problem for the Eurasian economic union development as international organization (hereinafter referred to as the EAEU), where is violated the economic and financial institutions’ functioning principle, the values, traditions and norms are lost. It is considered that one of the main crisis causes are the interstate economic policy of the EAEU member countries failures. The article proposes the ways to restore the EAEU countries’ economies from the crisis consequences, which periodization falls on 2015–2018, 2020–2022, that negatively affects on the single currency area they are creating, and examines potential economic and political threats during its formation. It is revealed that if the crisis inflicts damage on some EAEU members, then for other union members it will become a favorable deriving benefits environment, which will lead to inequality and even greater exacerbation. This paper shows that the Marxist crisis theory is the most acceptable approach in explaining economic inequalities and disproportions in the countries development. This approach led to the conclusion that the expansion of the Russian ruble circulation, the profits and capital accumulation, the formation of a new EAEU financial system based on the principles of capitalism and neoliberal values will lead to another crisis turn and increase inequality.
Digitalization of the Economy of Small Businesses — From Business Process Assessment to Goal Setting
Authors: Korkina Vera , Zmanovskaya Olga
Published: March 2024

The purpose of this article is to study and structure the identified problems in business processes in small business entities (hereinafter referred to as small business entities) that limit the implementation of measures during the transition period to the digital economy. The transition from traditional business to the digital economy format is currently associated with a number of systemic problems in the business processes of enterprises of the subjects of small and medium-sized businesses. The objects of the study were enterprises of small businesses of the Russian Federation in various industries: medical centers, private training centers and manufacturing enterprises. The subject of this research is the business processes within the enterprises under study. Its methodological basis is provided by the following methods: empirical, theoretical, sociological, psychological. As part of the research in the field of the problems in the economy and finance of enterprises of the subjects of small businesses and the transition to the digital economy in conditions of economic uncertainty, the authors of the article carried out research, analysis and evaluation of business processes. At this stage of the study, key business processes at enterprises have been identified within the framework of joint consulting projects at small businesses to assess the possibilities of transition to digitalization of the economy. The main problems in business processes hindering such a transition to the digital format of doing business are identified and classified, the points of business growth in the activities of enterprises are determined by the authors. We have studied and structured the identified problems of digitalization of business processes and proposed ways in order to solve them.
Prospects of Unconditional Basic Income in the Social Protection System: A Comparative Analysis of the Opinion of Objects and Subjects
Authors: Karpikova Irina , Solomein Aleksey
Published: March 2024

The article presents the results of a sociological study devoted to the problems of unconditional basic income. In recent years, interest in this topic has been actualized in Russian research practice, which is caused both by global trends in the search for effective tools to increase the level of social protection, and by the need to improve social protection mechanisms in our country. The analysis of scientific papers highlighted the problem of the lack of empirical studies that allow assessing the attitude to the introduction of unconditional basic income of the population as an object of social protection practices and professionals in the field of social protection as a subject introducing new tools in this area. In 2021–2022, the authors conducted an intelligence sociological study based on a questionnaire survey of 400 respondents living in various territories of the Irkutsk region, and 32 semi-structured interviews among managers and specialists in the field of social protection of the population of the Irkutsk region and the Republic of Buryatia. The focus of the analysis is focused on comparing the assessments and opinions of objects and subjects of social protection practices. For most of the studied aspects of the problems of unconditional basic income, a high degree of coincidence of estimates given by professionals in the field of social protection and ordinary respondents was noted. There is a generally low level of awareness of both categories of respondents regarding the studied mechanism of social protection. Assessing the problems and risks of introducing an unconditional basic income, respondents from among the population and social protection professionals come to general conclusions about the growth of social dependency, criminal manifestations, migration burden, as well as a possible lack of financial resources of the state to maintain the mechanism under consideration. A possible decrease in labor activity is considered as less likely. In general, the majority of respondents from among the population support the introduction of an unconditional basic income, while professionals in the social protection sphere consider it unlikely that this tool will be used in the foreseeable future.
ESG-Principles in Development
Authors: Matveeva Maria , Kustova Maria , Bezrukikh Olga
Published: March 2024

In recent years, the world community has largely formed the foundations of the ideology of world development for the coming decades, which are expressed in the paradigm of sustainable development through the introduction of ESG principles into the activities of the most companies in various sectors of the national economics. The interpretation and use of these principles in the activities of the most conservative industry of the Russian Federation, to which, according to most scientists, construction belongs, are not fully regulated, which makes it difficult to fully apply them and indicates the need to transform the operational activities primarily of development companies. The article analyzes the publications of independent research agencies that regularly analyze Russian companies for compliance with international standards of sustainable enterprise development, as well as directly development companies in Russia that are actively applying ESG principles in their operational activities at the moment. At the same time, special attention was paid to the problems of applying the sustainable development strategy in practice and ways to solve these problems. Moreover, the recently come into force standard of "green" construction for the evaluation of residential buildings GOST R 70346-2022 "Green Standards" was reviewed, as well as the current and proposed potential transformation processes of a development company at hierarchical levels, according to the ESG 2.0 strategy. The transformation processes of a development company proposed in the article on hierarchical levels are aimed at introducing the concept of ESG principles at each stage of the development project life cycle. That will provide a synergetic effect by defining new development priorities, economic, technological and cognitive sovereignty of development in the Russian Federation, as well as regulatory control over compliance with these principles not only during the construction of a building, but also at the stage of its operation.
ALKBH5 promotes hepatocellular carcinoma cell proliferation, migration and invasion by regulating TTI1 expression
Authors: Chang Qimeng , Zhou Xiang , Mao Huarong , Feng Jinfeng , Wu Xubo , Zhang Ziping , Hu Zhiqiu
Published: March 2024

The objective of this research was to investigate the potential mechanisms of AlkB homolog 5, RNA demethylase (ALKBH5) in hepatocellular carcinoma (HCC). We used The Cancer Genome Atlas (TCGA), Kruskal-Wallis method and Kaplan-Meier (KM) survival analysis to study the expression of ALKBH5 and its correlation with clinical factors in HCC. In vitro experiments verified the expression of ALKBH5 and its effect on HCC cell phenotype. We screened differentially expressed genes (DEGs) from HCC patients associated with ALKBH5. Through this screening we identified the downstream gene TTI1 which is associated with ALKBH5 and investigated its function using Gene Expression Profiling Interaction Analysis (GEPIA) along with univariate Cox proportional hazards regression analysis. Finally, we analyzed the functions of ALKBH5 and TTI1 in HCC cells. Across numerous pan-cancer types, we observed significant overexpression of ALKBH5. In vitro experiments confirmed ALKBH5 as an oncogene in HCC, with its knockdown leading to suppressed cell proliferation, migration, and invasion. Bioinformatics analyses also demonstrated a significant positive correlation between ALKBH5 and TTI1. TTI1, highly expressed in cells, showed promising prognostic ability for patients. Further experiments confirmed that suppressing TTI1 impeded cell growth and movement, with this effect partially offset by increased ALKBH5 expression. Conversely, promoting these cellular processes was observed with TTI1 overexpression, but was dampened by decreased ALKBH5 expression. In conclusion, our findings suggest that ALKBH5 may influence proliferation, migration and invasion of HCC by modulating TTI1 expression, providing a new direction for treating HCC.
Комплексные задачи городского управления
Authors: Эделенбос Йуриан , ван Дайк Майн Питер
Published: March 2024

В статье рассматривается понятие городского управления, анализируются факторы, влияющие на городское управление на национальном и местном уровнях и изучается вопрос о том, как городское управление справляется с общественными, экологическими и экономическими проблемами, с которыми городам приходится иметь дело сегодня. Основная сложность состоит в понимании этих проблем, и представленное исследование выявляет определенные факторы, способствующие успеху улучшенного управления городом: роль четких целей и лидерства; необходимость юридической базы, которая определяет роли различных участников; четкие механизмы принятия решений и обжалования; стимулы и соответствующие механизмы финансирования; сотрудничество между участниками и постепенное развитие доверия; четкое разделение обязанностей. В конце статьи представлены десять важных выводов из недавних работ, посвященных вопросам городского управления.
Хороший двор начинается с совета: как соучаствующее проектирование появляется в муниципальных округах Петербурга
Authors: Дмитриева Алина Евгеньевна
Published: March 2024

Автор анализирует причины появления практики соучаствующего проектирования на уровне муниципальных округов в Санкт-Петербурге. Сформулировав на основе опыта крупных российских городов пять случаев использования соучаствующего проектирования, автор сосредотачивается на последнем — на инициативе муниципальных советов применять практики вовлечения. Почему эта инициатива рождается, несмотря на сужающееся поле полномочий и урезающийся бюджет? Обзорсуществующей литературы позволил вывести гипотезы: на появление практик вовлечения в муниципальных округах может влиять средний возраст членов совета и ценности партий или общественных объединений, к которым они принадлежат. Была составлена база данных, содержащая сведения об 111 муниципальных советах в Санкт-Петербурге: количество депутатов в советах, попавших туда после выборов 2019 года, их партийная принадлежность, субъект выдвижения главы совета, средний возраст депутатов, ссылки на официальные и неформальные информационные ресурсы округа в интернете. Так как одним из принципов практик вовлечения, в частности соучаствующего проектирования, является прозрачная информационная кампания, автор использовал поиск в интернет-ресурсах анонсов о проектных семинарах по ключевым словам в качестве инструмента сбора сведений о наличии или отсутствии соучастия в округе. С помощью регрессионного анализа автору удалось подтвердить две гипотезы из трех: с возрастанием доли депутатов, выдвинутых условно демократическими силами, росла и вероятность встретить в округе соучаствующее проектирование, а с ростом среднего возраста депутатов в совете эта вероятность снижалась. Партийная принадлежность главы совета не показала значимого эффекта.
Lipopolysaccharide intraperitoneal injection in rats and sickness behavior assessment v2
Authors: not provided mariangela.massarocenere
Published: March 2024

This protocol is a quick guide to how to prepare a solution of LPS on the saline vehicle, how to inject a rat for an intraperitoneal injection, and how to monitor the animal after injection. The procedure must be done by trained persons and done according to local Animal Care legislation.
Intersecting Visions of Justice: The Philosophical Tapestry of Human Rights and Human Nature in the Thoughts of Macintyre, Arendt, Nino, and Habermas
Authors: Arrieta-López Milton , Certain-Ruiz Roberto
Published: March 2024

This study explores the philosophical foundations of human rights concerning freedom, equality, and solidarity through the lenses of Iusnaturalism, Iuspositivism, and Ethical Constructivism, with a special focus on Alasdair MacIntyre, Hanna Arendt, Carlos Santiago Nino, and Jürgen Habermas. It examines MacIntyre’s revision of Iusnaturalism with an Aristotelian approach, Arendt’s methodological Iuspositivism highlighting legal frameworks, Nino’s rationality-based human rights theory, and Habermas’ emphasis on communicative action and social constructs. This research navigates the dynamic interplay of these theories, offering a multi-dimensional perspective on the evolution, validation, and application of human rights in contemporary society. Significantly, it introduces a dialectical perspective on rationality as a dynamic and evolving human attribute, addressing the constructivist necessities in defining human nature amidst prevailing uncertainties.
PETRO KALNYSHEVSKY - A SYMBOL OF THE NATION'S INVINCIBILITY
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Kotsur Anatolіy , Kotsur Halyna ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: March 2024

220 years ago, the last kish otaman of the Zaporozhian Sich, Petro Kalnyshevsky, passed away. Modern society is increasingly in need of spiritual leaders who would serve as examples of high sincerity, honesty, justice, and love. The righteous life of P. Kalnyshevsky can become a spiritual authority for the moral improvement of society. Proof of this is the Orthodox Church of Ukraine's canonization of the Cossack otaman in July 2008. The capture and destruction of the Zaporozhian Sich has much in common with Russia's annexation of Crimea, the war in eastern Ukraine, and the large-scale Russian aggression against Ukraine that began on February 24, 2022. The article will help to better understand the policy of the Russian regimes towards Ukraine, the origins of the war, and dispel ideological myths. Studying and taking into account the experience of the past (positive and negative), drawing lessons from it, is considered an important task of scholars, the successful solution of which is impossible without extensive historiographical research. The article reveals the most important milestones in the life of the last kish otaman of the Zaporozhian Sich, Petro Kalnyshevsky (1691-1803). Attention is focused on his state, economic, military and charitable activities. P. Kalnyshevsky consistently defended the land interests and borders of the Zaporozhian Sich, actively settled the southern Ukrainian steppes, and contributed to the establishment of new settlements. He cared about the development of agriculture, crafts, and trade. Countering Russian expansion, P. Kalnyshevsky managed to implement a new progressive system of management that included the development of farms, the creation of Cossack winter quarters, and the rise of crafts, foreign and domestic trade. This, in turn, served as one of the main reasons for the liquidation of the Zaporozhian Sich, which hindered Russian economic interests in southern Ukraine. The military activities and military talent of the Cossack otaman, his participation in the Russian-Turkish wars of the eighteenth century are being revealed. Also, Kalnyshevsky's charity and his valuable gifts to spiritual shrines are being described. The Gospel, made at the expense of the otaman and presented to the church monastery, is described separately. Attention is drawn to P. Kalnyshevsky's solovetsky imprisonment, the terrible conditions of detention.
The Arbitrazh Court as a Subject of a Procedural Legal Relationship
Authors: Nosenko M. S.
Published: March 2024

The author makes an attempt to analyze the status of an arbitrazh court that enters into a procedural legal relationship with the participants during consideration of a particular case. The study was conducted on the basis of both general theoretical approaches and approaches developed by the science of civil procedure law to the essence of legal relations and civil procedural legal relations. Taking into account the place and role of the arbitrazh court in the system of judicial authorities, the work identifies specific features of this subject of procedural legal relations. In the author’s opinion, the fact that judicial power is exercised by the arbitrazh court through a procedural legal relationship is of particular importance for the characterization of the arbitrazh court. The status of the arbitrazh court as a judicial authority, in turn, determines the form of its procedural activity. Through the performance of procedural actions, the arbitrazh tribunal exercises its powers. The question of the competence of the arbitrazh court is considered as its characteristic, which determines the ability to become a subject of a procedural legal relationship and, at the same time, to act as the basis for its entry into a procedural legal relationship. The author analyzed legal institutions, as a result of which, when considering a particular case, two arbitrazh courts acquire mutual procedural rights and obligations.
Entrepreneurial Risk in Conditions of Economic Crisis: Analysis of Law Enforcement Practice
Authors: Guseinova G. E.
Published: March 2024

The significance of the risk category is generally recognized in Russian civil law. This institution becomes even more relevant in times of crisis, in times of economic instability and market volatility. An analysis of current judicial practice demonstrates that during the COVID-19 coronavirus pandemic and the introduction of sanctions restrictions, entrepreneurs were often forced to resort to amendment and termination of contracts due to a significant change in circumstances and to file claims for exemption from liability for violation of contractual obligations due to the occurrence of the force majeure. Russian courts apply these legal institutions in close connection with the category of business risk, however, due to the lack of a legal definition of this term and the wide variety of concepts of risk in legal doctrine, judicial discretion plays a significant role in resolving cases. Extremely broad discretionary powers of judges and legal uncertainty regarding business risk can lead to destabilization of civil law transactions and negatively affect the economic development of Russia. In this regard, the author advocates consolidating the concept of business risk, as well as its permissible and justified limits, if not at the legislative level, then at least in the explanations of Russian higher courts.
Three-dimensional simulation of spontaneous rupture: The effect of nonuniform prestress
Authors: Day Steven M.
Published: March 2024

abstract

We use a finite difference method to study crack propagation in a three-dimensional continuum, for conditions of both uniform and nonuniform prestress. The rupture criterion employed satisfies two fundamental physical requirements: it ensures finite stresses in the continuum and finite energy dissipation in crack extension. The finite stress numerical simulations exhibit abrupt jumps in rupture velocity when sharp changes in prestress are encountered on the crack plane, behavior analogous to that predicted theoretically for two-dimensional, singular cracks. For uniform prestress conditions, the slip velocity function is approximately a low-pass filtered version of that of a singular, constant rupture velocity crack. For nonuniform prestress, spatial variations of peak slip velocity are strongly coupled to spatial variations of rupture velocity.

For uniform prestress and low cohesion, rupture velocity is predicted to exceed the S-wave velocity in directions for which mode II (inplane) crack motion dominates. A subshear rupture velocity is predicted for directions of predominantly mode III (antiplane) crack motion. Introduction of stress heterogeneities is sufficient, in each of the three cases studied, to reduce average rupture velocity to less than the S velocity, but local supershear rupture velocities can still occur in regions of high prestress. Rupture models with significant segments of supershear propagation velocities may be consistent with seismic data for some large earthquakes, even where average rupture velocity can be reliably determined to be subshear.
A Educação Financeira em Institutos Federais do Maranhão: um Olhar nos PPCs
Authors: Aguiar Reullyanne Freitas de , Neres Raimundo Luna , Sales Francisco Alexandre de Lima
Published: March 2024

A Base Nacional Comum Curricular (BNCC) do Brasil, em seu arcabouço, sugere que a educação financeira deve ser considerada e refletida em sala de aula. Assim como, o marco orientativo do Decreto Federal 7.397/2010, em conjunto com a Estratégia Nacional de Educação Financeira (ENEF) que incentiva discussões desta temática na educação básica. Para isso acontecer efetivamente, é necessário que o professor possua apropriação de conhecimento relacionados á educação financeira e faça reflexões, destes, com seus alunos, em classe. Assim, discutiu-se neste artigo, a presença e/ou ausência de temáticas relacionadas a educação financeira nos cursos de formação inicial de professores de matemática do IFMA. Trata-se de uma pesquisa qualitativa, realizada com um olhar sobre os Projetos Pedagógicos dos Cursos (PPCs) destes cursos, na perspectiva de se analisar como sua abordagem ocorre. Assim, verificou-se que em nenhum dos oito campis do IFMA que ofertam o curso de formação de professores de matemática contemplam explicitamente tal discussão. A pesquisa revelou que nos PPCs existe a preocupação em formar docentes atentos as temáticas transversais, em conexão com outras disciplinas, de forma interdisciplinar, incentivando seus alunos a reflexão e criticidade, ponto em que pode trazer à tona temática relacionadas à educação financeira.
Palavras-chave: Educação Financeira. Educação Básica. Formação Inicial de Professores de Matemática. Objeto de Conhecimento.
AbstractThe National Common Curricular Base (BNCC) of Brazil, in its framework, suggests that financial education should be considered and reflected in the classroom. As well as the guiding framework of Federal Decree 7,397/2010, together with the National Strategy for Financial Education (ENEF), which encourages discussions on this topic in basic education. For this to happen effectively, it is necessary and sufficient that the teacher has appropriation of this object of knowledge and makes reflections, of these, with their students, in class. Thus, this article discusses the presence and/or absence of themes related to financial education in the initial training courses for mathematics teachers at IFMA. This is a qualitative research, carried out with a look at the PPCs of these courses, with a view to analyzing how their approach occurs, whether directly or indirectly. It was found that none of the eight IFMA campuses that offer the teacher training course explicitly contemplate such a discussion. The research revealed that in the Pedagogical Projects (PPC) of the mentioned courses, there is a concern to train teachers attentive to transversal themes, in connection with other disciplines, in an interdisciplinary way, encouraging their students to reflect and be critical.
Keywords: Financial Education. Basic Education. Initial Training of Mathematics Teachers. Object of Knowledge.
Frecuencia de Infección por el Virus de Inmunodeficiencia Humana en pacientes del Hospital Nacional durante el período 2021-2023
Authors: Jarolin Montiel Magali , Sánchez Lovera Luis , Arguello Alejandra , Benítez Clara , Montiel de Jarolin Dora
Published: March 2024

Introducción: el virus de la inmunodeficiencia humana sigue siendo de los principales problemas para la salud pública a nivel mundial ya que es causante de muertes a nivel global. La generalización del test del VIH en la población es una forma de estrategia de salud pública. Objetivo: determinar la frecuencia de la infección por el VIH en pacientes que acuden a urgencias en el período de marzo 2021 a octubre 2023. Metodología: estudio observacional, descriptivo, fueron incluidos pacientes adultos internados en el servicio de urgencias durante el periodo de marzo 2021 a octubre del año 2023. Para el cálculo del tamaño de la muestra basada en una proporción esperada de 0,1 (1 %) y una amplitud de 0,10 (precisión), nivel de confianza de 95 % lo que arrojó un tamaño de 974 pacientes. Los datos fueron procesados en el paquete estadístico EPI Info (Atlanta- CDC). Resultados: se incluyeron en el estudio 976 pacientes, la frecuencia de la seropositividad del virus de la inmunodeficiencia humana por test de ELISA fue del 12,8 % (n = 126) la media de edad de los pacientes positivos fue de 38,4 ± 13 años, en cuanto a los factores de riesgo 18,25 % (n = 23) refirieron consumo de drogas ilícitas; 16,66 % (n = 21) tatuajes; 11,90 % (n = 15) antecedente de transfusiones de hemoderivados; 7,14 % (n = 9) piercings. Conclusión: la frecuencia de la seropositividad del VIH por test de ELISA fue del 12,8 % en pacientes adultos que acuden a urgencias por cualquier razón.