bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação da distância intercaninos e sua correlação com as más oclusões
Authors: Melo Téssia Richelly Nóbrega Borja de , Souza Gustavo Ramos
Published: August 2020

O objetivo deste trabalho é avaliar a correlação entre a distância intercaninos e as más oclusões. Tratou-se de um estudo observacional e prospectivo, cujos dados foram coletados de 110 documentações ortodônticas e modelos de estudo, de pacientes entre 12 e 35 anos. As variáveis estudadas foram: idade, sexo, padrão racial, relação molar de Angle, más oclusões e distância intercaninos. Os dados foram anotados em formulário específico e distribuídos em tabelas, onde aplicou-se a estatística analítica através dos testes t Student e ANOVA (p<0,05). Os resultados foram os seguintes: a média de idade foi de 17,7 anos; a maioria da amostra foi do sexo feminino (58,7%) e de feodermas (43,6%). A relação de Classe I apresentou maior frequência (46,4% direita; 49,1% esquerda) e a má oclusão mais prevalente foi o apinhamento dentário (67,7%). As médias das distâncias intecaninos foram: 33,98mm, para a arcada superior e 26,11mm para a interior. A distância intercaninos na arcada superior de homens, foi estatisticamente maior que nas mulheres; assim como os arcos inferiores de jovens de 12 a 20 anos, foram maiores do que os de adultos de 21 a 35 anos. Concluiu-se que não houve correlação significativa entre a distância intercaninos e as más oclusões.
Aplicativo para conferência e controle de cirurgia segura – princípios para segurança do paciente em centro cirúrgico
Authors: Silva Rafael Henrique , Gatti Márcia Aparecida Nuevo , Lopes Jaqueline de Souza , Marafon Rafael Gustavo Corbacho , De Andrade Eliane Bergo de Oliveira , De Andrade Salazar Carmona
Published: August 2020

Objetivo: Testar um aplicativo para conferência e controle de todas as etapas do checklist de cirurgia segura sugerido pela Organização Mundial da Saúde para a segurança do paciente submetido à cirurgia. Métodos: O trabalho utilizou de um aplicativo desenvolvido a segurança do paciente. Os resultados foram armazenados em banco de dados digital e analisados o tempo para aplicação do checklist, o nível de adesão, a porcentagem de etapas que foram realizadas e preenchidas corretamente e quais das etapas foram mais deficientes fazendo posteriormente uma comparação a literatura. Resultados: O aplicativo é uma ferramenta passível de ser utilizada, a adesão ao checklist de segurança do paciente precisa ser estimulada e a apresentação imediata do risco do paciente pode potencializar da cultura de cirurgia segura. Conclusão: O aplicativo de cirurgia segura otimiza a utilização do checklist de cirurgia segura, alerta os profissionais sobre os riscos para a segurança do paciente, quantifica e apresenta em tempo real o risco para a segurança do paciente durante o procedimento cirúrgico.
Intervenções de profissionais de enfermagem para a assistência espiritual: uma revisão narrativa
Authors: Hutul Silva Sonia , Maria dos Santos Santiago Ribeiro Beatriz , Scorsolini-Comin Fabio , Takeo Okamura Carlos , Aparecida Penha Martins Eleine
Published: August 2020

Objetivo: Refletir, a partir de uma narrativa da literatura científica, sobre as intervenções de profissionais de enfermagem para a assistência espiritual. Revisão bibliográfica: Partiu da atual Classificação das Intervenções de Enfermagem, que menciona 56 ações relacionadas ao cuidado religioso-espiritual, bem como do diálogo entre essas recomendações e os estudos consolidados na área de religiosidade/espiritualidade e saúde. Destaca-se que a assistência de cunho religioso-espiritual ofertada pelo enfermeiro deve respeitar dilemas éticos, crenças religiosas e cuidados de saúde, bem como a própria opção do paciente ou de sua família de não incluírem esses elementos no cuidado. O profissional, dessa forma, deve estar conectado com essas necessidades, abrindo-se à escuta do paciente e de seus familiares em relação a essa dimensão. Considerações finais: Ao se apropriar da temática da religiosidade e da espiritualidade o enfermeiro conhece subsídios e aportes teóricos para nortear a aplicação de intervenções espirituais no processo de tomada de decisão para a condução da assistência.
Strategic Documents in the Museum Sphere: International Experience
Authors: Grinko Ivan A.
Published: August 2020

In some European countries, strategic development documents have alredy been included in the official standard of museum work, and this is gradually becoming a mandatory element of the museum management in the Russian Federation as well. In this regard, there is an urgent need for at least a general description of the scenario for preparing and structuring such documents. As evidenced in practice, the issue of creating strategic planning documents is still relevant for the museum sphere in Russia. One of the ways to solve this problem is use modern international experience. The article analyzes the formats of strategic plans created by individual museums and museum associations in the museum sphere of the United Kingdom and the United States. There are reviewed nine such documents. The article focuses on their structure, i.e. the main semantic elements and presentation format. In the preparation of strategic documents of museums, the following points can be noted: there is an obvious tendency to reduce the documents and present the most important elements in their final text. The elements usually include the following sections: mission (and/or values), main goals/activities and tasks, image of the future. Much less often, they include principles and analysis of the major challenges. The analytical part is usually not allocated to a separate section, being either included in an appendix, or designed as insets to the corresponding parts of the text. There is paid much attention to the visual appearance of strategic documents and their impact on actual and potential stakeholders: both texts and design are primarily aimed at the external audience. As evidenced in practice, the modern museum strategy is becoming not just a tool for museum management, but also an extremely important tool for public relations.
Creating New Information and Communication Models in Working with Users within the Google Library Project
Authors: Savitskaya Tatiana E.
Published: August 2020

The article analyzes characteristic features and development logic of the library project by Google, which started from the famous Google Book Search project (also known as Google Books and Google Print), and later as Google Play Books within the multi-platform multimedia service Google Play. For decades, a constant trend of the corporation’s activity has been the development and testing of new social and communication models in working with users, combining the complexity and global reach of the audience with the use of its interactive potential. In the early 2000s, the company initiated mass scanning of library collections, thus starting the development of a new institutional paradigm for electronic libraries. Later, having developed new business models for the distribution of electronic copies of printed products in the course of numerous legal proceedings on charges of copyright infringement, it also pioneered the new information market development.

From the very beginning, Google Book Search was aimed at the mass user, which was facilitated by its constantly expanding set of options and increasing level of comfort of access to the resource. In 2006—2010, the service presented an opportunity for users to download, in pdf format, books free of copyright law; a new viewing interface “About this book” was added; an opportunity to operate texts using “My library” option was provided; a mobile version of the service was launched; access to statistical information on diachronic frequency dynamics of word usage based on the collected database was provided.

The article analyzes the further development of the library project within the Google Play Books service, which allows users to read, buy and sell e-books, use bookmarks, download their own books in pdf and EPUB formats, and synchronize data on all user’s devices. There is assessed the social significance of the project in the context of the global electronic civilization development.
ABCs of the Revolution
Authors: Yesyunin Egor A.
Published: August 2020

The article is devoted to the satirical agitation ABCs that appeared during the Civil War, which have never previously been identified by researchers as a separate type of agitation art. The ABCs, which used to have the narrow purpose of teaching children to read and write before, became a form of agitation art in the hands of artists and writers. This was facilitated by the fact that ABCs, in contrast to primers, are less loaded with educational material and, accordingly, they have more space for illustrations. The article presents the development history of the agitation ABCs, focusing in detail on four of them: V.V. Mayakovsky’s “Soviet ABC”, D.S. Moor’s “Red Army Soldier’s ABC”, A.I. Strakhov’s “ABC of the Revolution”, and M.M. Cheremnykh’s “Anti-Religious ABC”. There is also briefly considered “Our ABC”: the “TASS Posters” created by various artists during the Second World War. The article highlights the special significance of V.V. Mayakovsky’s first agitation ABC, which later became a reference point for many artists. The authors of the first satirical ABCs of the Civil War period consciously used the traditional form of popular prints, as well as ditties and sayings, in order to create images close to the people. The article focuses on the iconographic connections between the ABCs and posters in the works of D.S. Moor and M.M. Cheremnykh, who transferred their solutions from the posters to the ABCs.
A Steady-State Algebraic Model for the Time Course of Covalent Enzyme Inhibition
Authors: Kuzmic Petr
Published: August 2020

This report describes an algebraic equation for the time course of irreversible enzyme inhibition following a two-step mechanism. In the first step, the enzyme and the inhibitor associate reversibly to form a non-covalent complex. In the second step, the noncovalent complex is irreversibly converted to the final covalent conjugate. Importantly, the algebraic derivation was performed under the steady-state approximation. Under the previously invoked rapid-equilibrium approximation [Kitz & Wilson (1962) J. Biol. Chem. 237, 3245] it is by definition assumed that the rate constant for the reversible dissociation of the initial noncovalent complex is very much faster than the rate constant for the irreversible inactivation step. In contrast, the steady-state algebraic equation reported here removes any restrictions on the relative magnitude of microscopic rate constants. The resulting formula was used in heuristic simulations designed to test the performance of the standard rapid-equilibrium kinetic model. The results show that if the inactivation rate constant is significantly higher than the dissociation rate constant, the conventional “kobs” method for evaluating the potency of covalent inhibitors in drug discovery is incapable of correctly distinguishing between the two-step inhibition mechanism and a simpler one-step variant, even for inhibitors that have very high binding affinity in the reversible noncovalent step.
High Pressure Amplifying Framework Materials for Programmable Pneumatics Systems
Authors: Bon Volodymyr , Krause Simon , Senkovska Irena , Grimm Nico , Wallacher Dirk , Többens Daniel D. , Kaskel Stefan
Published: August 2020

Negative Gas Adsorption (NGA), discovered in a series of mesoporous switchable MOFs, was hitherto regarded as a curios phenomenon occurring only at pressures well below or close to atmospheric merit. Herein we demonstrate mesoporous frameworks interacting with carbon dioxide, to show stimulated breathing transitions well above 100 kPa. Reversible CO2 adsorption-induced switching was observed in DUT-46 (DUT = Dresden University of Technology), in contrast to irreversible transitions for DUT-49 and DUT-50, as demonstrated via synchrotron in situ PXRD/adsorption experiments. Systematic physisorption experiments reveal the best conditions for high pressure NGA transitions in the pressure range of 350 - 680 kPa. The stimulated framework contraction expells CO2 in the range of 1.1 to 2.4 mmol g-1 leading to autonomous pressure amplification in a closed system. In a pneumatic demonstrator system we achieved pressure amplification of 90 kPa at a high operating pressure of 340 kPa. According to system level estimations even higher theoretical pressure amplification may be achieved between 535 kPa and 1011 kPa for DUT-49 using CO2 as a non-toxic and non-flammable working gas. Operable pressure ranges exceeding 100 kPa render pressure amplifying framework materials as realistic candidates for the integration into energy autonomous responsive pneumatic systems.
Magnetic Control over the Topology of Supramolecular Rod Networks
Authors: Marichez Vincent , Sato Akihiro , Dunne Peter , Leira-Iglesias Jorge , Formon Georges , Schicho Michaela , de Feijter Isja , Hébraud Pascal , Bailleul Matthieu , Besenius Pol , Venkatesan M. , Coey J.M.D. , Meijer E.W. (Bert) , Hermans Thomas
Published: August 2020

Understanding and controlling supramolecular polymerization are of fundamental importance to create advanced materials and devices. Many stimuli have been explored in the past decades, but magnetic fields and field gradients have received little attention. This is because magnets do not provide enough magnetic energy to overcome thermal noise at the single molecule level. Here we show that significant changes in network topology of Gd3+-decorated supramolecular polymer rods can nevertheless be observed using magnetic fields of order 1 T at room temperature. The structure of the rod networks is influenced during a slow diffusive process over a timescale of hours by the anisotropy of the demagnetizing field. Our approach opens opportunities to control and tune structure formation of many supramolecular and coordination polymers using a variety of rare earth or other paramagnetic ions.
Synthesis and Characterization of Fluorescent Probes for the Development of a Ceramide Synthase FRET-Based Assay
Authors: Izquierdo Eduardo , Casasampere Mireia , Fabriàs Gemma , Abad José Luis , Casas Josefina , Delgado Antonio
Published: August 2020

Ceramides are recognized to occupy a pivotal position in sphingolipid metabolism, playing a fundamental role as membrane structural components, as well as second messengers. Ceramide synthases (CerS) are a family of enzymes that catalyze the N-acylation of sphingosine and dihydrosphingosine, thus controlling the levels of intracellular ceramides. In this work, we present the synthesis and the fluorescent properties of new probes for the development of a FRET-based assay for CerS activity. Based on our previous discovery of spisulosine as a suitable probe for CerS activity in cells, the use of a modified NBD-spisulosine with a clickable fatty acid as CerS substrates may allow the ultimate formation of a bichromophoric reporter for a FRET-based analysis of CerS activity in cells.
Effectiveness of Colloidal Gas Aphron Fluids Formulated with a Biosurfactant Enhanced by Silica Nanoparticles
Authors: Tabzar Amir , Sadatshojaie Ali , Wood David A.
Published: August 2020

At-balance drilling technology applications demand the use of special drilling fluids, For example, colloidal-gas-aphron fluids (CGA) are being deployed to good effect in drilling applications. GCA-based drilling fluids have physico-chemical attributes that enable them to usefully influence and control downhole conditions. Furthermore, the involvement of nanoparticles and surfactants in their formulations enhances the performance and stability of CGA suspensions. This study describes the stability analysis, rheological characterization and filtration properties of CGA suspensions for the novel eco-friendly biosurfactant, Olea europaea (common olive), in presence of nanoparticles. Filtration and stability analysis was performed using API filtration tests and the static drain-rate technique, respectively. Several rheological models are developed to quantify the shear-flow characteristics of Olea-nano-based CGA suspensions. The Herschel-Bulkley and the Mizhari-Berk models provided the best shear-flow prediction accuracy with very small error values in terms of root mean squared error. Results reveal that the introduction of the biosurfactant improves the CGA-based fluid properties. Moreover, the observed improvements are further enhanced by including silica and fumed silica nanoparticles in the formulations. The Olea-nano-CGA-based fluids exhibit non-Newtonian behavior. The rheology of CGA-based fluids depends upon base-fluid viscosity, as it does in aqueous polymeric foams. The optimum concentrations of nanoparticles in Olea-nano-based CGA fluids is identified to provide them with fluid-flow indices ranging between 0.15 and 0.30.
Iridium-Catalyzed Asymmetric α-Allylic Alkylation of Amides using Vinyl Azide as Amide Enolate Surrogate
Authors: Chakrabarty Aditya , Mukherjee Santanu
Published: August 2020

Among the unstabilized enolates used as nucleophile in iridium-catalyzed asymmetric allylic alkylation reactions, amide enolates are least explored. Vinyl azides are now employed as amide enolate surrogate for the first time in Ir-catalyzed asymmetric allylic alkylation with branched allylic alcohols as the allylic electrophile. Competing reaction pathways are suppressed through systematic tuning of steric and electronic properties of vinyl azide to effect α-allylic alkylation of secondary acetamides with high atom-economy, exclusive branched selectivity and moderate to excellent enantioselectivity.
Prediction of Single Point Mutations in Ganglioside-Binding Domain of SARS-CoV-2 S and Their Effects on Binding of 9-O-Acetylated Sialic Acid and Hidroxychloroquine
Authors: Mitrasinovic Petar M.
Published: August 2020

The infectious disease CoViD-19 is caused by a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also referred to as hCoV-19. A possible infection mechanism includes dual host receptor recognitions by the SARS-CoV-2 transmembrane spike (S) glycoproteins. SARS-CoV-2 S contains two different domains, the receptor-binding domain (RBD) and the N-terminal domain (NTD), which interact with the angiotensin-converting enzyme 2 (ACE2) and the ganglioside-rich domain of the plasma membrane at the surface of respiratory cell, respectively. The NTD amino acid residues (111-162) form a functional ganglioside-binding domain (GBD) that is conserved in all clinical isolates. Herein, the single point mutations (SPMs) of the GBD residues to which the virus is prone during genetic adaptation are predicted using an in silico protein engineering approach. Consequently, their effects on the attachment of SARS-CoV-2 S to the ganglioside-linked 9-O-acetylated sialic acid (9-O-Ac-Sia) are explored using molecular docking simulations. Val120Tyr and Asn122Trp are found to be the most likely SPMs in the GBD of SARS-CoV-2 S being involved in very specific recognition with 9-O-Ac-Sia through electrostatic interactions. Val120Tyr and Asn122Trp are also found to be the most likely SPMs in the GBD of SARS-CoV-2 S that is involved in conspicuously hydrophobic recognition with hidroxychloroquine (Hcq), thereby indicating the ability of Hcq to competitively inhibit GBD interactions with lipid rafts. However, the considerably non-specific binding of Hcq and the micromolar range of the dissociation constants of the SARS-CoV-2 S/Hcq complexes do not support the proposal of treating Hcq as a drug candidate. Maintaining a clear resemblance of the structure of a potential drug candidate to a natural substrate, accompanied by essential functional group modifications, may be a usable guideline for the structure-based design of anti-CoViD-19 drugs.
Role of Vitamin D in prevention of Corona virus infection (COVID-19)
Authors: Surbhi Juneja  , Suwarna Dangore-Khasbage  , Rahul R Bhowate
Published: August 2020

Corona viruses enveloped positive-sense RNA viruses causes various diseases in mammals as well as birds which range from upper respiratory tract infection to potentially lethal human respiratory syndrome. In humans, Severe Acute Respiratory Syndrome corona virus 2 (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) which shows symptoms like fever, sore throat, gasping and ultimately pneumonia, lung injury and leading to death. The virus acts on various systems of our body, and one of them is the Renin-Angiotensin system. It is supposed that the virus causes cell injury by acting on Angiotensin-Converting Enzyme 2 (ACE2) receptors which causes an increase in the level of Angiotensin II, leading to inflammation and lung injury. An essential vitamin can prevent this in our body that is vitamin D. It acts on Renin-Angiotensin system (RAS) by inhibiting the action of renin and also by increasing production of ACE2 and hence Angiotensin II level decreases which prevent inflammation and lung injury. So vitamin D has a remarkable and pivotal role in modulation of the immune system of our body and hence protects human from this fatal disease.
Variations in platelet indices in hypercholesterolemia patients in a tertiary care hospital
Authors: Janani K  , Muthuvel E  , Sudha Vasudevan
Published: August 2020

Hypercholesterolemia is defined as high levels of cholesterol in the blood. Platelet indices include: Plateletcrit (PCT), Platelet Distribution Width (PDW) and Mean platelet volume (MPV). Hypercholesterolemia is associated with the increased risk of developing cardiovascular diseases like atherosclerosis which in turn results in platelet activation and thrombotic events. This study is aimed to evaluate the variations in platelet indices in adults with hypercholesterolemia which may be significant in indicating cardiovascular diseases. It is a retrospective case-control study which includes 50 patients with a total cholesterol level of more than 170mg/dl as the study group and 50 healthy controls with normal lipid profile parameters. Data were collected from the lipid profile register in the Biochemistry department of Saveetha Medical College for 3 months duration. The fasting blood samples were run in the machine ‘vitros 5600 dry chemistry’. The lipid profile values included in this study were Total cholesterol, HDL and TGL. The platelet indices were collected from the automated haematology analyzer 'Sysmex XN 1000' from the Pathology Department, Saveetha Medical College. The data collected were tabulated and analysed using SPSS software. Statistical tool used is the independent T-test. The mean value of the platelet parameters such as MPV, PCT and PDW in the study group was 10.397061, .3000, and 12.452 respectively and that of the control group was 9.907480, .2882, 11.174 respectively. On comparing the platelet parameters such as MPV, PCT and PDW between the study and the control group it was observed that there was a significant variation in MPV and PDW. In the independent sample test, the p-value of MPV, PCT and PDW were 0.21, 0.481 and 0.008, respectively. Thus MPV and PDW shows a significant variation between the study and the control group as it is higher in hypercholesterolemia patients (p-value is <0.05).
Peptide-based quorum sensing systems in Paenibacillus polymyxa
Authors: Voichek Maya , Maaß Sandra , Kroniger Tobias , Becher Dörte , Sorek Rotem
Published: August 2020

Paenibacillus polymyxa is an agriculturally important plant growth–promoting rhizobacterium. Many Paenibacillus species are known to be engaged in complex bacteria–bacteria and bacteria–host interactions, which in other species were shown to necessitate quorum sensing communication. However, to date, no quorum sensing systems have been described in Paenibacillus. Here, we show that the type strain P. polymyxa ATCC 842 encodes at least 16 peptide-based communication systems. Each of these systems is comprised of a pro-peptide that is secreted to the growth medium and processed to generate a mature short peptide. Each peptide has a cognate intracellular receptor of the RRNPP family, and we show that external addition of P. polymyxa communication peptides leads to reprogramming of the transcriptional response. We found that these quorum sensing systems are conserved across hundreds of species belonging to the Paenibacillaceae family, with some species encoding more than 25 different peptide-receptor pairs, representing a record number of quorum sensing systems encoded in a single genome.
Validation of an online questionnaire of vocabulary learning strategies for ESL learners
Authors: Gu Yongqi
Published: August 2020

© 2018, Adam Mickiewicz University Press. All rights reserved. This article reports on the updating and validation of a questionnaire for vocabulary learning strategies. An English as a second language (ESL) version of the Vocabulary Learning Questionnaire (VLQ), first published in Gu and Johnson (1996), was created based on its latest version. Two response formats were piloted, that is, a paper version with a 7-point Likert scale and an online version with a 100-point slider bar. A series of validation procedures resulted in a 62-item instrument which was then administered online among 682 English language learners at the tertiary level in China. The paper presents evidence of content validity, construct validity, internal consistency reliability, and predictive validity. It also provides suggestions for interpreting and using the questionnaire for both research and instructional purposes.
O Ensino de Ciências por Investigação em Construção: Possibilidades de Articulações entre os Domínios Conceitual, Epistêmico e Social do Conhecimento Científico em Sala de Aula
Authors: Franco Luiz Gustavo , Munford Danusa
Published: August 2020

Neste artigo, analisamos como estudantes construíram discursivamente articulações entre os domínios conceitual, epistêmico e social do conhecimento científico. A turma investigada estava no 1° ano do Ensino Fundamental e estudava a biologia de um inseto. Para construção e análise de dados, utilizamos aspectos da Etnografia em Educação. Foi realizada observação participante, registros em áudio e vídeo, além de coleta de artefatos produzidos pelos estudantes. Os resultados indicam que o uso de recursos instrucionais, organizados em torno do trabalho com perguntas, geraram diferentes caminhos para as articulações entre os três domínios, evidenciadas no discurso oral dos participantes. A ênfase no par [epistêmico+social] conferiu um caráter mais investigativo ao contexto instrucional, possibilitando a melhor compreensão do processo de construção do ensino de ciências por investigação. Discutimos implicações para a prática pedagógica e para pesquisa em Educação em Ciências.
Inter-related issues that impact motivation in biomedical sciences graduate education
Authors: Chen Zhi Xiong , Lee Shuh Shing , Samarasekera Dujeepa D. , Stalmeijer Renee
Published: August 2020

The expansion of biomedical sciences has seen a recent boom in the number of graduate students and early career scientists. However, the lack of motivation and increasing departure of graduates from research careers were not well explained in current literature. Elements such as intrinsic motivation and external factors may play moderating or independent roles in altering these outcomes. Using semi-structured interviews, we sought to investigate the role of intrinsic motivation and external factors in shaping biomedical sciences graduate students’ and early career biomedical scientists’ research experiences, and the impact on their perceived research performance and expected career longevity. Using thematic analysis, our data from 10 graduate students or early biomedical scientists participants from uncover several aspects of intrinsic motivation such as its intensity, foundation and nature, and specific external factors such as the presence or absence of social support, the need for career progression driven by societal pressure, and the nature of the research environment that could all influence the students’ and trainees’ psychological state of mind. In turn, this could impact their perceived research performance ability, and desire to stay or leave the biomedical research field. Our study provided an in-depth perspective into the underlying reasons for leaving biomedical sciences or the lack of ‘feel-good’ in research besides competition, funding and publications. This could lead to further discussions on policy changes and interventions that could improve biomedical sciences graduate education and training in future.
Predictors of clinical reasoning in neurological localisation: A study in internal medicine residents
Authors: Loh Kieng Wee , Rotgans Jerome Ingmar , Tan Kevin , Tan Nigel Choon Kiat
Published: August 2020

Introduction: Clinical reasoning is the cognitive process of weighing clinical information together with past experience to evaluate diagnostic and management dilemmas. There is a paucity of literature regarding predictors of clinical reasoning at the postgraduate level. We performed a retrospective study on internal medicine residents to determine the sociodemographic and experiential correlates of clinical reasoning in neurological localisation, measured using validated tests.
Methods: We recruited 162 internal medicine residents undergoing a three-month attachment in neurology at the National Neuroscience Institute, Singapore, over a 2.5 year period. Clinical reasoning was assessed on the second month of their attachment via two validated tests of neurological localisation–Extended Matching Questions (EMQ) and Script Concordance Test (SCT). Data on gender, undergraduate medical education (local vs overseas graduates), graduate medical education, and amount of clinical experience were collected, and their association with EMQ and SCT scores evaluated via multivariate analysis.
Results: Multivariate analysis indicated that local graduates scored higher than overseas graduates in the SCT (adjusted R2 = 0.101, f2 = 0.112). Being a local graduate and having more local experience positively predicted EMQ scores (adjusted R2 = 0.049, f2 = 0.112).
Conclusion: Clinical reasoning in neurological localisation can be predicted via a two-factor model–undergraduate medical education and the amount of local experience. Context specificity likely underpins the process.
Supporting medical science educators: A matter of self-esteem, identity, and promotion opportunities
Authors: Dickinson Bonny L. , Chen Zhi Xiong , Haramati Aviad
Published: August 2020

Medical science educators are faculty members primarily responsible for teaching the medical sciences to healthcare profession students. These educators also have roles in other academic areas such as curriculum development, learner assessment, advising and mentoring, clinical duties, research, institutional service, leadership and administration. Academic institutions worldwide are increasingly focused on excelling in cutting-edge research, a major criterion for university rankings, which has led to significant resources and attention invested in those endeavours. At the same time, the primary goal of academic institutions is to educate and train healthcare professionals. As a result, medical science educators are often caught in the middle of these competing interests, leading to the ambiguity between personal career development and institutional priorities. It is in this context that we consider how medical science educators might navigate these issues and how academic institutions can support and strengthen this important cohort of faculty. First, with an attempt at humour, we begin by considering three stereotypical identities of medical science educators. We then discuss how the growing number of medical education associations and programs designed to support medical science educators are making a difference. Our goal is to provide a clear direction for the current career trajectory of medical science educators.
Can an online clinical communication course impact learner behaviour?
Authors: Chow Cristelle , Lim Cynthia , Thoon Koh Cheng
Published: August 2020

Background: Effective communication between doctors and patients leads to better compliance, health outcomes and higher doctor and patient satisfaction. Although in-person communication skills training programs are effective, they require high resource utilisation and may provide variable learner experiences due to challenges in standardisation.
Objective: This study aimed to develop and implement an evidence-based, self-directed and interactive online communication skills training course to determine if the course would improve learner application of communication skills in real clinical encounters.
Methods: The course design utilised the Kalamazoo Consensus framework and included videos based on common paediatric clinical scenarios. Final year medical students in academic year 2017/2018 undergoing a two-week paediatric clerkship were divided into two groups. Both groups received standard clerkship educational experiences, but only the intervention group (88 out of 146 total students) was enrolled into the course. Caregiver/patient feedback based on students’ clinical communication was obtained, together with pre- and post-video scenario self-reported confidence levels and course feedback.
Results: There were minimal differences in patient feedback between intervention and control groups, but the control group was more likely to confirm caregivers’/patients’ agreement with management plans and provide a summary. However, caregivers/patients tended to feel more comfortable with the intervention compared to the control group. Median confidence levels increased post-video scenarios and learners reported gains in knowledge, attitudes and skills in paediatric-specific communication.
Conclusion: Although online video-based communication courses are useful standardisation teaching tools, complementation with on-the-job training is essential for learners to demonstrate effective communication.
Representaciones de la identidad neoleonesa en los spots de las campañas a la gubernatura de Nuevo León de 2015
Authors: Moyssén Álvarez Xavier
Published: August 2020

Este trabajo toma como punto de partida el modelo sociológico del voto, según el cual las características sociales determinan las preferencias políticas. Se propone que la identidad regional, al ser un componente socializado, pudo tener efectos sobre el comportamiento electoral de la elección a gubernatura de Nuevo León de 2015. El objetivo de este trabajo no es indagar sobre el resultado de la elección, sino verificar, a través de un análisis de contenido, la presencia de elementos de identidad neoleonesa dentro de los spots propagandísticos de campaña de los principales candidatos: Felipe de Jesús Cantú (PAN), Ivonne Álvarez García (PRI) y Jaime Heliodoro Rodríguez Calderón (independiente). Además, se propone una explicación teórica de los posibles efectos de estos elementos en el comportamiento electoral y su relación con las políticas de la posverdad.
AYURVEDIC MANAGEMENT OF EK-KUSHTA (PSORIASIS)-A CASE STUDY
Authors: Singh Arora Dr. Bhupinder
Published: August 2020

Psoriasis is described in Ayurveda as ek-kushta, it is type of kshudrakushta. The number of people suffering from Psoriasis all over the world is increasing progressively. Ayurvedic medicine is oriented toward prevention, health maintenance and treatment of diseases. There is large number of drugs of herbal and mineral origin mentioned in Ayurvedic texts, regarding the treatment of ek-kushta. The present case study is successful Ayurvedic management of a case of ek-kushta (psoriasis). Here a case report of a 35 years-male having with the complaint of ubhay pad pradeshi twak aaraktavarniya twakavaivarnya, kandu, twakrukshata etc. since 2 months. He was treated with Ayurvedic herbs & some panchkarma procedure which give effective result with Ayurvedic Management.
Factors and methods of effective management. P. 3. Labor motivation and personnel retention, labor efficiency
Authors: Gusakov V. G.
Published: August 2020

There is an active search for ways and mechanisms to upgrade the agrarian economy in the Republic of Belarus and increase its efficiency in conditions of stiffen market situation, but no efficient mechanisms have yet been found. In this regard, we’ve carried out systematic research and prepared a research papers that answer many questions regarding raising the agricultural economy and market challenges. We believe that it can become the basis for accepting specific recommendations. The third paper dwells on the role, functions and significance of such fundamental factors of efficient agriculture management as labor motivation, personnel retention and labor efficiency.
Analysis of polymorphism of strawberry genotypes (Fragaria L.) according to the strawberry red root spot resistance gene RPF1 for identification of strawberry forms promising for breeding and horticulture
Authors: Lyzhin A. S. , Luk’yanchuk I. V.
Published: August 2020

Red root spot (Phytophthora fragariae var. fragariae Hickman) is one of the most important strawberry diseases in the temperate climate zone. Identification of forms, carrying resistance genes, is an important stage in breeding programs aimed at obtaining red root spot resistant strawberry varieties. Diagnostic DNA markers of target genes will increase reliability of identification and efficiency of strawberry breeding for the creation of resistant genotypes. The purpose of this study is analysis of polymorphism of wild species of Fragaria L. genus and strawberry varieties (F. × ananassa Duch.) according to the strawberry red root spot resistance gene Rpf1 using molecular markers. The research sunjects were the wild species F. orientalis Los., F. moschata Duch., F. ovalis Rydb., F. virginiana Duch. ssp. platypetala and strawberry varieties (F. × ananassa Duch.) of different ecological and geographic origin. Total genomic DNA of strawberry was extracted from the fresh leaves using the Puchooa method. To assess the allelic state of Rpf1 gene, SCAR-R1A marker (linked to the Rpf1 dominant allele) and OPO-16C marker (linked to the rpf1 recessive allele) have been used. SCAR-R1A marker was identified in wild species F. virginiana Duch. ssp. platypetala (vegetation region: British Columbia, Canada), pineapple strawberry varieties Bylinnaya and promising selected forms 62-41 (Bylinnaya × Feyyerverk), 65-17 and 65-24 (Olimpiyskaya nadezhda × Bylinnaya). These genotypes are characterized by heterozygous Rpf1rpf1 genotype according to Rpf1 gene (both markers are present in genotype) and can be used as red root spot resistance source in marker-assisted selection. In the remaining studied genotypes of strawberry, SCAR-R1A marker was not detected, which presumably indicated their homozygous recessive genotype rpf1rpf1 according to Rpf1 gene. The research results can be useful for breeders of strawberry and researchers of plant biodiversity of p. Fragaria.
Ego-­documents as sources for the history of Belarusian national movement in interwar western Belarus
Authors: Gorny A. S.
Published: August 2020

The main theoretical approaches that exist in domestic and foreign historiography on the problem of ego­docu­ ments are given in the introduction. Role of the Dutch historian Jacques Presser in creation of this term and its use in foreign historical science in the 1980–1990s is analyzed. The author of the article, taking into account European experience, is trying to give his own definition of the term “ego­documents”, adapted to Belarusian historiography. The author also notes the scientific feasibility of the active use of ego­documents when studying the history of the Belarusian national movement in the interwar Western Belarus.

The main part of the article reveals the scientific value of ego­documents as sources for studying various topics related to the history of the Belarusian national movement in the interwar Western Belarus. As an example, the author took letters to the Vilnius Belarusian bookstore, and analyzed the scientific potential of business correspondence as part of epistolary sources. Five types of memoir literature, which help to expand knowledge about various figures of the Belarusian movement in the interwar Western Belarus, were formed. An analysis of university autobiography and curriculum vitae emphasizes the lack of knowledge of this type of ego­documents and its scientific value in the study of relations between Belarusian activists and the Polish state.

In conclusion, conclusions are drawn about the insignificant use of ego­documents in the study of the history of Bela­ rusian nationalism in the interwar Western Belarus. The anthropological turn in historiography has determined the desire of modern historians to pay attention to the everyday problem of the Belarusian movement, its local features that determines the active use of ego­documents as sources.
A. F. Kovalev – Belarusian artist, sculptor, designer, teacher
Authors: Gorbunov I. V.
Published: August 2020

The biography of the Belarusian artist, sculptor, designer, teacher, professor Anatoly Fedorovich Kovalev is considered. A. F. Kovalev was one of the organizers of Belarusian education in the field of fine and decorative arts. He was the author of the first design dissertation in the BSSR, a member of the Union of Artists of theUSSRand Belarusian Union of Artists, a veteran of the Great Patriotic War. During his long career he transferred knowledge and a huge professional experience to more than one generation of talented students, including workers of culture and art ofBelarus– V. K. Lebedko, M. Sakhuto, G. F. Shauro, V. I. Prokoptsov. In1965 A. F. Kovalev, being the head of the department of decorative and applied art of the art and graphic department of the Vitebsk State Pedagogical Institute named after S. M. Kirov (now Vitebsk State University named after P. M. Masherov), made a lot of efforts to transfer technical work into the artwork channel based on traditional techniques of decorative processing of materials, and also influenced the development of history and design theory at the initial stage of its formation. The contribution of A. F. Kovalev to the sphere of culture and art of theRepublicofBelaruswas marked by many state awards.

The article is addressed to young designers, artists, sculptors, teachers of the humanities and technical disciplines, research scientists who are interested in the history of design.
Solid groundbreaking research
Authors: Rusilka V. I.
Published: August 2020

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BANK’S INVESTMENT ACTIVITY
Authors: Gutkevych Svitlana , Jureniene Virginija
Published: August 2020

The article considers the investment system that is determined by the investment activity of financial institutions. The banking system is a dynamic system, the basis of the economic infrastructure of the market. The bank's investment operations are a complex process because the bank can be both an object and an investor. The bank's investment choices are influenced by the following major factors: expected rate of return, tax characteristics, mortgage requirements, risks.The stability of the banking system depends on the general equilibrium conditions between accumulation and investment demand. The state of the banking system affects investment. The structure of the modern banking system in Ukraine is in line with Western counterparts, and the domestic legal framework in the banking sector is perfect enough to regulate banking processes and ensure the stability of the banking sector. In a broader context, international investment processes are influenced by: the state of development of the world economy, international factor and investment markets; stability of the world monetary system; development of international investment infrastructure and the like. In the context of globalization, international investment is influenced by the interacting processes of trans nationalization and regional economic integration. The effects of global economic factors, on the one hand, offset some of the differences between countries, and on the other, it creates a macro environment for large-scale activity of international entities and investment institutions.
EVALUATION OF RISK IMPACT ON IMPLEMENTATION OF INNOVATION PROJECTS WITHIN THE FRAMEWORK OF MACHINE-BUILDING QUASI-INTEGRATION STRUCTURES
Authors: Solntsev Sergii , Zhygalkevych Zhanna , Kravchenko Maryna
Published: August 2020

The risk management of innovation project can improve the level of risk control of quasi-integration structures (QIS), so as to make more effective decisions, reduce investment losses and achieve mutual benefit as well. Therefore, an assessment of the risk impact on implementation of innovation project makes this study relevance. The purpose of this paper is to analyze the impact of market risks on the success of innovative QIS engineering projects with the involvement of an economic-probabilistic model based on a conjoint analysis. Research methodology. The article substances the feasibility and results of the application of the method of conjoint analysis – one of the methods of mathematical psychology – to assess the impact of risks on the effectiveness of innovative projects implemented within quasi-integration structures in the engineering complex. Findings. The most likely scenarios for implementing an innovative project in terms of the impact of risk events on the financial result had been found with a help of a conjoint procedure with a fractional factorial design. The relative impact of each risk on the success of the innovation project was evaluated. The rule of deciding on the eligibility of an innovative project by the participants of machine-building QIS was formulated on the basis of the technique of the internal rate of investment return (IRR). Research limitations. The developed methodology is proposed to be used in assessing the impact of risks on innovative projects within machine-building quasi-integration structures. The proposed method of assessing the impact of risks on the financial results of innovative projects within the machine-building QIS can be used in more general situations. Practical implications. The methodology was tested on the example of an innovation project within an innovation and technology cluster, which included six participants: mechanical engineering companies, a service company, a scientific institution and an educational institution. The market and specific inter-corporate risks that influence the results of innovative projects within machine-building QISs were identified and evaluated for operationalization. According to the results of implementation of the methodology, the feasibility of implementing an innovative project within the innovation-technological cluster was substantiated. Originality/value. The scientific novelty of this study is the use of a conjoint analysis methodology to assess the impact of market risks.