bluuebunny/crossref_metadata_2025 huggingface dataset:
Food Sovereignty: An Analysis of the Cañamomo Lomaprieta Indigenous Reservation, Local Resistances against Domination
Authors: Rey-Lema Diana María , Peña-Galindo Andrés
Published: January 2025

In Colombia, the indigenous people are recognized as a special population and can establish self-governance regulations in their territories. Although this provision materialized with the Constitution of 1991, the spread of globalization and dynamics of domination around the world have created neocolonial challenges for native peoples. Such is the case of the indigenous reservations of Cañamomo Lomaprieta, which have experienced impositions when introducing their agricultural practices. These communities have organized resistance to consolidate food sovereignty respectful of their worldview. This research article aims to elucidate, based on decolonial and postcolonial approaches, the resistance processes undertaken by the Cañamomo Lomaprieta reservation in the Riosucio municipality as examples of responses to the neocolonial dynamics prevalent in the agribusiness economy today; transnational companies have been developing this economy in the third food regime. Practices such as the conservation of native seeds to avoid bioengineering are described, in addition to presenting ancestral methods to ensure that food, sustainable crops, and knowledge survive for a long time.
Transforming Quantum Programmes in KDM to Quantum Design Models in UML
Authors: Jiménez-Navajas Luis , Pérez-Castillo Ricardo , Piattini Mario
Published: January 2025

Quantum computing has come to stay in our lives. Companies are investing billions of dollars in it because of the potential benefits that it can achieve, providing promising applications in almost every business sector. Although quantum computing is evolving at an exponential rate, the development of tools, techniques, or frameworks for the evolution of current information systems towards quantum software systems is still proving to be a challenge. This research contributes to the evolution of current information systems towards hybrid information systems (combining the classical and quantum computing paradigm). We propose a software modernization process, by following model-driven engineering principles, adapted to the quantum paradigm, based on modified versions of standards for reverse engineering of classical, quantum software assets, and for the design of the target system. In particular, this paper focuses on the restructuring transformation from KDM to UML models, where KDM models have been generated from Q# code. This proposal has been validated through a case study involving 17 programmes. The results obtained show optimistic values regarding the complexity of the UML models generated, their expressiveness and scalability. The main implication of this research is that UML models can indeed help the software evolution of/toward hybrid information systems.
Totalitarian Realia: Abbreviation-Based Sovietisms and the Methodology of Their Recreation in English Translations of Ukrainian Literature
Authors: Malaiko Serhii
Published: January 2025

This paper explores the topic of totalitarian realia, represented by Sovietisms in the Soviet Union, from linguistic, ideological, and translation-oriented perspectives. Sovietisms can be categorized into two types: conventional and abbreviation-based. An analysis of three translations of Ukrainian Soviet-era literary works, which make extensive use of Sovietisms, identifies 139 examples. The primary focus of this paper is on abbreviation-based Sovietisms, which constitute 65.5% of the research corpus, encompass many unique linguistic phenomena, and are predominantly rendered through a domesticating approach (76%), despite the nation-narrating objectives of their translators. Based on this analysis, the key strategies for translating abbreviation-based Sovietisms into English are outlined. Additionally, an alternative strategy, termed combined renomination (calque), is proposed for foreignization-oriented nation-narrating translations involving abbreviation-based Sovietisms.
Distopijos naujakalbė Davido Mitchello romano „Debesų atlasas“ vertime: leksinis ir morfologinis lygmuo
Authors: Navickaitė Eglė , Kudirka Robertas
Published: January 2025

The article examines the lexical and morphological features of newspeak in Laimantas Jonušys’s Lithuanian translation of David Mitchell’s dystopian novel Cloud Atlas. The research material is drawn from an excerpt of the chapter “Teliūskas perkėla i visa paskum” (pp. 279–308) and its corresponding part in the original text (pp. 213–236). In the translation, the features of newspeak are conveyed through lexical and semantic neologisms, occasional and potential formations, as well as typical and atypical derivational variants. Additionally, literally translated and passive lexical layer words play distinctive roles. The findings demonstrate that formation by analogy and the recognizable variability of specifying lexical and morphological elements in relation to standard language contribute to a convincing representation of the dystopia’s artistic vision, effectively rendering the original newspeak and its post-apocalyptic impression.
A New Object of Translation Studies: The Lithuanian Eurolect
Authors: Pekūnas Žygimantas
Published: January 2025

This article aims to introduce readers to the Lithuanian Eurolect and stimulate research on this underexplored topic. It provides a brief overview of Eurolects—i.e., Europeanized variants of EU official languages shaped by translation and language contact. The article reviews existing studies on Eurolects and explores the hypothetical Lithuanian Eurolect. It outlines systematic approaches to studying this phenomenon with the aid of corpora and suggests potential research avenues, including lexical, grammatical, and discourse features of Eurolects.
La interculturalidad y la enseñanza del inglés como segunda lengua en el preescolar.
Authors: De La Hoz Margarita Rosa
Published: January 2025

El artículo trata de una investigación de corte etnográfico y cualitativo con 65 docentes del área de preescolar en la enseñanza del inglés en la ciudad de Barraquilla, divido en dos grupos, los cuales participaron bajo la modalidad CIPAS, o círculos de interacción, participación académica social, consistente en entablar discusiones y reflexiones en torno al currículo y pedagogía para la enseña del inglés. A los profesores se les aplicaron varios cuestionarios para determinar su apropiación en los saberes, a partir de discusiones y sesiones de trabajo centradas en identificar las Debilidades, Oportunidades, Fortalezas y Amenazas como estrategia para llegar a un diagnóstico y posterior ajuste y mejoramiento del currículo. Algunos resultados aconsejan que la adquisición del inglés se debe centrar en el aprendizaje a través del juego, basándose en la investigación y la filosofía de Jean Piaget, que postula al juego como satisfactor de las necesidades físicas, intelectuales, lingüísticas, emocionales y sociales de los niños.
Violencia, mujer y atención policial en el municipio de Soledad (Atlántico): prospectiva sostenible de educación para la ciudadanía
Authors: De Arco Ballesteros José Luis , Caro Barrios Luis Miguel , Vásquez Torres Habid Junior
Published: January 2025

Este trabajo tiene como propósito exponer las percepciones de las mujeres del barrio Ferrocarril y Ciudadela Metropolitana del Municipio de Soledad en el departamento del Atlántico frente a sus consideraciones en materia de violencia contra la mujer y su atención policial. Asimismo, señalar los principales casos de violencia reportados, con el fin de ofrecer una prospectiva educativa sostenible sobre denuncias y canales de atención policial, recalcando la pertinencia de disponer de políticas públicas, planes, programas y acciones para erradicarlos y ejercer una ciudadanía en torno a los Derechos Humanos y a la importancia del género desde un modelo de complementariedad.
21st Century skills in the Ecuadorian school context: Students' critical thinking, problem-solving and decision making
Authors: Villafuerte Jhonny , Pin Zambrano Odalys Micaela , Saldarreaga Vélez Odalys Yamileth
Published: January 2025

This work aims to improve the critical thinking, problem-solving, and decision-making in elementary education students in Ecuador. It used a mixture of qualitative and quantitative research approaches to collect information to analyzes the participants' perceptions and knowledge concerning 21-century skills. They were sixty-four participants, including 59 students and five teachers from two educational institutions in Manta, Ecuador. They were organized in experimental and control groups to participate in an educational intervention to strengthen students' skills during 2020. It administrated an adaptation of the 21CLD learning activity rubric proposed by Stehle and Peters-Burton (2019). The research instruments were focus groups, Likert questionnaires, and class observation. The results show that teachers and students are aware of the application of 21st-century skills in the school context. Furthermore, It found significant differences between the critical thinking, problem-solving and decision making skills pretest and post-test in the experimental group and control group. Thus, it concluded that the skills of 21st-century citizenship could be strengthened in the school context using appropriate pedagogical activities since English as a foreign language class.
Diálogos Interculturales: Lengua de Señas y Lengua Palenquera para una Etnoeducación Inclusiva
Authors: Franco Bracamonte Jaime Rafael , Díaz Pérez Mirian
Published: January 2025

El presente trabajo se enmarca en una política de reconocimiento a las diferencias de la población afrocolombiana en la educación, el objetivo es analizar los diálogos interculturales entre la lengua de señas y la lengua Palenquera para una Etnoeducación inclusiva en las Instituciones Educativas Salvador Suárez Suárez y Paulino Salgado Batata de Barranquilla. La metodología fue cualitativa y método etnográfico con un diseño de campo emergente y flexible, se tomaron como informantes clave a cinco estudiantes; la información se obtuvo mediante el guion de la entrevista. El resultado indica que es fundamental el reconocimiento y la valoración de las diferencias para el diálogo intercultural de la lengua de señas y la palenquera en jóvenes sordos por la disposición de la población objeto de estudio. Se concluye que es necesaria la implementación de la lengua de señas y la palenquera en el proceso de aprendizaje de los estudiantes pues constituyen un elemento de inclusión y de calidad Etnoeducativa. Así mismo, se concluye que la riqueza diferencial del español y la palenquera, trae consigo un pensamiento más refinado, que establece matices y connotaciones variadas y complejas, en la creación, el arte y el resto de las actividades humanas.
La interculturalidad como campo de aprendizaje de un idioma extranjero
Authors: Sánchez Parra Yuberney
Published: January 2025

El objetivo de este trabajo es aportar una reflexión teórica sobre el proyecto “Promoción de campos de aprendizaje bilingüe a través de las Bellas Artes, las Humanidades y la Psicología” de la Universidad de Cundinamarca.  Este trabajo pretende resaltar un elemento fundamental a la hora de aprender una segunda lengua y es el factor de la “interculturalidad” como horizonte reflexivo que supera los métodos preestablecidos de aprendizaje. Como conclusión, la interculturalidad no solo es un valor fundamental para aprender un idioma extranjero, sino, que además, es escenario ético del reconocimiento del Otro y su cultura.
Modelo de abordaje psico-emocional de atención a la mujer víctima de violencia sexual
Authors: Barraza Pulido Elsa Isabel
Published: January 2025

El presente estudio tuvo como propósito conformar un modelo de atención psico-emocional para la mujeres víctimas de violencia sexual, manejo como objetivo general Generar un Manual de abordaje psico - emocional para la atención a la mujer víctima de violencia sexual, como variable independiente utilizo la violencia sexual, de naturaleza cuantitativa, ubicado como una investigación descriptiva, con diseño de campo, no experimental-transversal y de modalidad proyectiva, con una muestra de 20 mujeres víctimas de violencia sexual, que acuden a consulta de sexología médica en el Centro de Cirugía Estética “La Trinidad” ubicada en la Ciudad de San Juan de Colon, del Municipio Ayacucho del Estado Táchira, Venezuela, la técnica de recolección de datos fue el cuestionario estructurado con 20 preguntas de respuesta múltiple tipo Likert. La validez del instrumento fue mediante juicio de expertos, dos psicólogos y un psiquiatra y la confiabilidad mediante criterio de Alfa de Cronbach, de un 0.91, considerado altamente confiable, se concluyó que las consecuencias negativas a nivel psico-emocional producida por una violación sexual pueden ser disminuida mediante una atención priorizada a estas víctimas, se recomendó divulgar el presente trabajo con el objeto de colaborar en la estabilización psico-emocional de las víctimas de este flagelo social.
Extreme learning machine to foretell the deflection in plain cement, steel-reinforced, and bamboo-reinforced concrete beams
Authors: Dubey Saurabh , Gupta Deepak , Mallik Mainak
Published: January 2025

In mountainous regions, bamboo has gained popularity as a local reinforcement material for concrete due to its availability and cost-effectiveness. However, the lack of standardized design guidelines complicates the assessment of deflection behavior under varying loads. Challenges such as bond failure, shrinkage, corrosion, and material strength uncertainties further limit its structural application. To address these issues, this study employs an extreme learning machine to predict deflection in plain cement concrete beams, steel-reinforced cement concrete beams, and bamboo-reinforced concrete beams. The performance of extreme learning machine is compared with support vector regression and artificial neural networks. A total of 122 specimens were analyzed using input features such as cement content, water-cement ratio, fine aggregate, coarse aggregate, tensile strength, concrete compressive strength, percentage of reinforcement, applied load, cross-sectional area, and clear cover. The extreme learning machine method demonstrated satisfactory performance with a coefficient of deformation of 0.9975, Mean Square Error of 0.0003, Mean Absolute Error of 0.0052, Mean Absolute Percentage Error of 0.0998, and Root Mean Square Error of 0.01694. These results suggest that extreme learning machine is an efficient machine learning algorithm for predicting the deflection behavior of different reinforced concrete beams, providing a reliable alternative to traditional methods.
Innovative solution for sulfate challenges in lime stabilisation of Cochin marine clays
Authors: A. R. Sindhu , Abraham Benny Mathews , Pillai Anitha G. , Sridharan Asuri
Published: January 2025

The current study focuses on the long-term strength reduction in lime-stabilised Cochin marine clays with sulfate content. By introducing 6% lime and 4% sulfates to untreated Cochin marine clay, the research aims to investigate the effect of sulfates in these clays. Unconfined compression tests were conducted on lime-treated clay both with and without additives, immediately after preparation and over 1 week, 1 month, 3 months, 6 months, 1 year, and 2 years of curing. Test results indicated that both sodium sulfate and lithium sulfate have a negative impact on the strength gain of lime-stabilised clay. To address this issue, barium hydroxide, in both its pure laboratory form and the commercial product known as ‘baryta’, was incorporated into the lime-stabilised soil. The study showed a consistent increase in shear strength with the addition of both barium hydroxide and baryta. When twice the predetermined quantity of baryta was added to lime-stabilised clay, it outperformed pure barium hydroxide in terms of strength enhancement. Results of scanning electron microscopy and X-ray diffraction analysis align with the strength characteristics. The cost-effective use of baryta offers a practical solution to counteract strength loss in lime-stabilised, sulfate-bearing Cochin marine clays.
Probability modelling of pedestrian collision at signalised intersections
Authors: Piralaiy Mohsen , Ghasemzadeh Tehrani Hosein , Choupani Abdoul-Ahad
Published: January 2025

The behaviour of pedestrians and drivers at signalised intersections are analysed. Three pedestrian safety evaluation methods including “accident analysis technique”, “traffic interference technique” and “traffic condition evaluation” are reviewed and compared. Simulation of movement in real conditions at intersections is done and the results are compared. Results show that time of day is an important factor that affects the behaviour of drivers. Evening driving reduces the minimum distance and minimum ‘time to crash’ (TTC), implying morning driving is less dangerous than driving in the evening. Vehicle movement and pedestrian-pedestrian movement only affect the minimum distance and minimum TTC. In addition, the pedestrian-passerby visibility factor is investigated to investigate the effects on drivers' behaviour. Based on the results, the average RSE is 1.23 m, which means that the average difference between the minimum distance predicted and the minimum distance obtained is 1.23 m. The R square for the model is 0.922, which indicates that 92.2% of the variation in the experimental data can be explained by the variation in the prediction results. Based on this, the results showed that the prediction model of pedestrian and vehicle interference has a good predictive performance.
Wear- and corrosion-resistant iron-based amorphous coating in diluted biodiesel medium
Authors: Ibrahim Mahmoud Z. , Mohd Zulkifli Nurin Wahidah , Syahmi Ahmad F. , Sarhan Ahmed A. D. , Bakeer Bahi
Published: January 2025

Biodiesel is an eco-friendly source of energy that is synthesized from plant- or animal-based oils and fats. However, the commercial use of biodiesel is limited due to its drawbacks such as auto-oxidation and moisture absorption, leading to accelerated corrosion of the metallic parts and degradation of wear resistance. In this work, a novel amorphous metal coating was proposed to promote the wear and corrosion resistance under multigrade diesel engine oil (15W-40) diluted with 7% palm oil–based biodiesel (B30). The coating was performed using laser cladding technique at different scanning speeds (40 and 60 mm/s) and constant laser power 280 W. Microstructure investigation and X-ray diffraction confirmed amorphous structure and crystalline phase (FeCr). It was found that the wear rate was reduced for the coated specimens by about 90% compared with the uncoated samples. The corrosion rates decreased by 54.74% and 69.96% for scanning speeds 40 and 60 mm/s, respectively. Thanks to the reduced microstructural defects such as grain boundaries in the amorphous structure of the coating. These findings showed that amorphous metal coating provides promising solutions to increase the reliability of using biodiesel without the need for corrosion inhibitors, which reduce the combustion efficiency.
Can architectural salvage contribute to net zero resource and waste management?
Authors: Williams Ian D. , Ripley Sophie , Daskalova Elitsa
Published: January 2025

Factors that influence the success of architectural salvage and reclamation yards are unknown. This study aimed to: (a) identify the architectural salvage supply chain and investigate barriers/incentives to processing salvaged materials efficiently, (b) categorise/quantify salvaged materials and critically evaluate their potential, financially and environmentally, (c) evaluate perceived historical and aesthetic value of salvaged versus new objects, and (d) compare the environmental performance of common salvage versus new items. Data were collected from an online catalogue to review the scale/composition of the industry in the South-east of England. Surveys of reclamation/salvage yards and the public were undertaken. The architectural salvage market consists of small businesses sourcing salvage from few sources. Businesses have little influence on each other regarding market prices and decide these based on the qualities of individual items. There is limited customer awareness of environmental benefits. Storing architectural salvage items is a key barrier for businesses. Salvage businesses reduce disposal through sales. Raising awareness of salvage yards, their range of products and environmental benefits are key if reclamation is to contribute to expansion of material reuse. Architectural salvage could make a small but important contribution to net zero resource and waste management, especially in the construction sector.
2019 ve 2024 İlkokul 1. Sınıf Türkçe Dersi Öğretim Programlarının Karşılaştırılması
Authors: Gürbüz Burak , Duran Erol
Published: January 2025

Bu çalışmada, 2019 ve 2024 ilkokul 1. Sınıf Türkçe Dersi Öğretim Programlarının (TDÖP) temel yaklaşımları, içerik yapıları, ilk okuma-yazma yöntemleri ve ölçme-değerlendirme yaklaşımlarının karşılaştırılması amaçlanmıştır. Bu amaç doğrultusunda çalışmada nitel araştırma yöntemlerinden doküman incelemesi kullanılmıştır. Bulguların analizinde nitel içerik analizi kullanılmıştır. Elde edilen bulgulara göre 2019 TDÖP’nin bilişsel gelişim ve yapılandırmacı temele dayalı olduğu görülürken, 2024 TDÖP’de "Türkiye Yüzyılı Maarif Modeli" çerçevesinde daha çok yönlü bir gelişim modeli benimsenmiştir. İçerik bakımından kazanım sayılarında büyük bir artış bulunmuş ve konuşma becerisinin kazanım oranı büyük ölçüde artırılmıştır. Ayrıca, 2024 öğretim programında ilk okuma ve yazmaya geçişte sosyal-duygusal gelişime daha fazla vurgu yapılmıştır. Öğretim programları arasında harf gruplarında, okuma yazmaya geçiş uygulamalarında, defter biçimlerinde değişiklikler bulunmaktadır. Bunların yanında 2024 TDÖP’de örnek ölçme-değerlendirme araçları ile öğretmenlere rehberlik sağlanmıştır.
Harald Bodenschatz: Auftrag Achsenmacht. Skizzen zu einem diktatorischen Projekt
Authors: Bodenschatz Harald
Published: January 2025

Über Jahrzehnte war es selbstverständlich in der westdeutschen Gesellschaft, auch in der Fachwelt, die Achse als Signatur nationalsozialistischer Raumpolitik zu sehen. Noch heute poppen gleich die Bilder auf, wenn vom NS-Städtebau die Rede ist: die «GROSSE HALLE», der riesige TRIUMPHBOGEN, die «WELTHAUPTSTADT GERMANIA» und vor allem: die NORD-SÜD-ACHSE. Das ist natürlich nicht ganz falsch, aber viel zu kurzsichtig, denn eine solche eindeutige Zuschreibung macht es allzu leicht, sich von diesem «Größenwahn» zu distanzieren und die notwendige Auseinandersetzung mit Diktatur und Städtebau im Nationalsozialismus vorzeitig zu beenden.
Johan Schloemann: Gute Achsen, böse Achsen. Zur Rhetorik der Kulturkriege
Authors: Schloemann Johan
Published: January 2025

Er hatte zuvor gebetet. Als Mike Johnson am 20.April 2024 sich nach monatelanger Blockade im Repräsentantenhaus der Vereinigten Staaten dazu durchrang, über Milliardenhilfen für die Ukraine, Israel und Taiwan abstimmen zu lassen, soll er vor der Entscheidung Gott angerufen haben. Der Sprecher des Repräsentantenhauses und fromme Republikaner sagte nach dem Beschluss des Hauses in die Fernsehkameras, heute stellten Russland, Iran und China «the new axis of evil» dar. Indem er mit der neuen Teufelsachse die Abkehr von den isolationistischen Präferenzen seiner radikalisierten Partei legitimierte, griff Johnson eine manichäische Metaphorik auf, die GeorgeW. Bush, der 43.Präsident der USA, im Jahr 2002 zur Rechtfertigung seines «Kriegs gegen den Terror» verwendet hatte.
Dissociation of Anopheles sp midgut into single-cell suspension for scRNAseq v1
Authors: Pinaud Silvain , not provided Virginia.Howick , Lawniczak Mara
Published: January 2025

Dissociation of Anopheles sp midgut into a single-cell suspension for scRNAseq Here, we develop a method of cold dissociation for the mosquito midgut and salivary gland tissues that results in cell viability and recovery sufficient for scRNA-seq using a cold-activated protease from Bacillus licheniformis isolated from Himalayan glaciers (Adam et al. 2017). Dissociation of fragile tissues at 4-6ºC has the potential to decrease stress-related artefacts compared to 37ºC proteolytic dissociation (Adam et al. 2017; O'Flanagan et al. 2019) . This method enabled us to recover sufficient cells from mosquito salivary gland and midgut tissues for scRNAseq.
Physico-mechanical properties of autoclaved aerated concrete block as an alternative to traditional bricks
Authors:   Civil Engineering Department, ICFAI University Tripura, Kamalghat, Tripura – 799210, India, Paul Ashim , Dey Palash ,   Civil Engineering Department, ICFAI University Tripura, Kamalghat, Tripura – 799210, India, Dhar Mrinmoy ,   Mechanical Engineering Department, ICFAI University Tripura, Kamalghat, Tripura – 799210, India
Published: January 2025

Autoclaved aerated concrete (AAC) can be treated as a sustainable construction material as it decreases environmental impact while enhancing urban development quality, aligning with sustainable development goal (SDG) 11 of United Nations. The present study aims to compare the properties of the AAC blocks with that of traditional bricks such as fly ash brick and clay brick to emphasize the distinct advantages and limitations of AAC blocks, proposing AAC as a potential alternative in construction sector. AAC blocks of different aluminum powder (0.025 % and 0.05 % Al) and the masonry prisms of these AAC blocks as well as fly ash bricks and clay bricks were prepared in the laboratory. The compressive strength of AAC block was found to be 5.01 N/mm2 which is higher than the minimum strength according to IS code. The compressive strength of a masonry unit was observed greater than that of masonry prisms in all cases. It was found that the AAC blocks contain minimal moisture, thus suitable for the walls subjected to damp environments continuously as compared to the walls prepared by using fly ash bricks and clay bricks. The microstructural morphology was also obtained using scanning electron microscope (SEM) equipment. It had been observed that the pore size enlarged with the inclusion of Al powder in AAC. As a result, the weight of AAC block reduced, thereby the density and compressive strength also decreased. Due to this characteristic, a masonry structure constructed with AAC blocks is recommended to perform well during earthquake in terms of seismic resistant compared to a structure prepared with traditional bricks. Furthermore, resource-based cost analysis method had been adopted to demonstrate with an example of model room that the cost of building construction can be reduced with the employment of AAC blocks by 29% and 36% as compared to clay bricks and fly ash bricks respectively.
Single-Flow Automated Line with Intermediate Storage and Various Types of Downtime of Production Cells
Authors:   Sevastopol State University, Higher mathematics Department, Sevastopol, 299053, Russian Federation, Olshanskay I. V. , Fedorenko S. N. ,   Sevastopol State University, Higher mathematics Department, Sevastopol, 299053, Russian Federation
Published: January 2025

In technology we widely use semi-Markov processes, because with their help someone can model a large number of production systems. For increasing automated production flexibility and reliability workers use storage devices in different roles, such as inter- operational buffers in conveyor production, as loading and unloading solutions, as modules with the ability to store products, etc. On the other hand, during operation, off-cycle time losses (downtime) occur, which have a significant impact on the system. In this regard, problems arise in constructing mathematical models based on them, taking into account the features, structure and purpose of such systems, making it possible to identify and analyze those types of downtime that have the greatest impact on their functioning. It is known that in practice we cannot completely eliminate any type of downtime during operation, so the our research goal is to develop a mathematical model that will allow us to determine by what amount certain downtime can actually be reduced and how this will effect on the reliability and efficiency characteristics. In this paper, for a single-threaded automated line with intermediate storage devices, we build a semi-Markov model with a discrete-continuous phase state space. Then, using the asymptotic phase enlargement algorithm, we find expressions for the approximate calculation of the system under consideration stationary reliability characteristics. In the final part of the article, as an illustration of our results, we present the calculated stationary characteristics values using the example of a three-phase system for different processing times of the outlet device.
Results of the Development of National Research Computer Network of Russia within the Framework of the National Project "Science and Universities" in 2021—2024
Authors:   National Research Centre "Kurchatov Institute", Abramov A. G. , Gonchar A. A. ,   National Research Centre "Kurchatov Institute", Evseev A. V. ,   National Research Centre "Kurchatov Institute", Shabanov B. M. ,   National Research Centre "Kurchatov Institute"
Published: January 2025

The paper presents and discusses the main results of work on the development of the National Research Computer Network of Russia (NIKS) performed within the framework of the national project "Science and Universities" in 2021-2024. The implemented activities are considered to eXpand the territorial accessibility and increase the throughput of the backbone infrastructure, ensure high-speed and reliable sectoral network connectivity, and connect the country's leading research and educational organizations of higher education to the network. The dynamics of development of the network backbone infrastructure, regional coverage, gradual increase in the number of connected organizations and some other statistical information about the user base are presented. Prospects and possible directions for further development of NIKS are discussed.
ACADEMIC INTEGRITY DEVELOPMENT IN EDUCATIONAL TRAINEES FOR SPECIALTY 011 PROFESSIONALS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, ZHYLENKO Mykola
Published: January 2025

Background . As evidenced by the practice of organizing the educational process, the contradiction between the necessity of adhering to
the principles of academic integrity in educational activities and the development of approaches and means for its purposeful formation during the
educational process is not fully resolved today. In response to a prompt query to ChatGPT about the consequences of declining education quality
and deception during assessment, artificial intelligence provided an answer that the responsibility for the country's future is not limited to military
threats alone but begins with the quality of education, as it affects the development of the economy, medicine, justice, and other spheres of life.
Results. The article reveals the logic and approaches to forming academic integrity in organizing the educational process within the
framework of the Educational and Pedagogical Sciences specialty 011. Through analysis of the legislative and normative base, research on the state
of academic integrity in education, types, frequency, and regularities of its violations among students, it is clarified that there is currently an increase
in the level of violations and diversification of academic misconduct, primarily explained by the opportunities of information and communication
technologies. Factors positively influencing the formation of academic integrity in professional training are considered. Based on their description, a general strategy for forming academic integrity in higher education as a whole, as well as the content and logic of its formation in organizing the
educational process on the Educational and Pedagogical Sciences specialty 011, are proposed. The requirements of the legislative and normative
base implemented in the content of the educational program are demonstrated. The possibilities of implementation by educational institutions are
analyzed. The results of checking the integrity of higher education trainees confirm the effectiveness of the proposed strategies.
Conclusions. Strategies for forming academic integrity among students of specialty 011 as a legal and ethical category are justified. When
introducing disciplines aimed at implementing integrity principles in work programs, the formation and clear understanding of its specific provisions
should be envisaged.
FORMATION OF ACADEMIC INTEGRITY AMONG FUTURE OFFICER-LEADERS IN THE EDUCATIONAL PROCESS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, ZBORCНYI Andrii
Published: January 2025

Background. This article is dedicated to the formation of academic integrity among cadets as future officer-leaders in military educational
institutions. In this publication, academic integrity is considered as a set of ethical principles and norms that all participants in the educational
process of higher education institutions should adhere to (Verkhovna Rada of Ukraine "On Education", 2017). Integrity serves as the foundation for
building trust and respect in the military educational environment, ensuring honesty, fairness, and accountability in the assessment of cadets'
knowledge and skills. In higher military educational institutions, where the new generation of military elite (leaders) is shaped, academic integrity
plays a significant role and holds special importance. It determines the quality of education, preparation for performing official duties, and
responsibility towards the state and society. The importance of shaping moral-philosophical and ethical values among future officer-leaders is
explored.
Methods. Theoretical (analysis, synthesis, interpretation, abstraction, generalization, analogy and comparison – for structuring and
analyzing the impact of the formation of academic integrity in future officer-leaders during the training process; generalization – to formulate the
conclusions of the study.
Results. The given ways of forming academic integrity and measures to increase it are aimed at creating a favorable environment for the
development of academic integrity, where every cadet has the opportunity to fully develop his potential, adhering to high ethical standards. They
form the basis for the formation of the moral and ethical consciousness of future officer-leaders, which is reflected in their activities both in peacetime
and in the conditions of combat missions.
Conclus і ons. Various methods and strategies aimed at raising awareness (self-awareness) of those who study regarding the principles
of academic integrity (virtue) are analyzed. Effective approaches to instilling morality and integrating integrity values into the educational process of
higher education institutions are highlighted.
Ubiquitylation in the development of somatic diseases: a mechanism of cellular regulation and a new therapeutic target
Authors: Urakov Aleksandr L. , Tyurin Anton V. , Shchekin Vlas S. , Siddikov Olim A. , Abdurakhmonov Ilkhomjon R. , Gabdrakhimova Renata A. , Samorodov Aleksandr V.
Published: January 2025

At the present stage of medical science, an increasing role in the pathogenesis of various groups of diseases is assigned to the mechanisms of epigenetic regulation and posttranslational modifications of proteins. One of these mechanisms is ubiquitylation, which is able to regulate the functional activity of proteins, their stability, and also influence the processes of cell death. Involvement in a large number of metabolic pathways and presently identified associations with oncological, cardiovascular, neurological, and inflammatory diseases makes ubiquitylation of the enzymes involved a promising target to develop new therapy options. In this review, we consider the effect of ubiquitination on the development of diseases of the cardiovascular, nervous systems, diabetes mellitus, as well as the development of possible treatment options.
Specifics of COVID-19 therapy in elderly, senile, and long-living patients: pharmacoepidemiological study data
Authors: Petrov Vladimir I. , Ryazanova Anastasia Yu. , Tokareva Natalia S.
Published: January 2025

BACKGROUND: The effect of age on COVID-19 course and specifics of drug therapy in geriatric patients represent relevant issues for research.
AIM: To study the age-dependent structure of drug prescriptions in COVID-19 patients admitted to the infectious diseases department of the Volgograd region in 2020–2022; to assess the effectiveness and safety of drug therapy in elderly, senile, and long-living patients.
MATERIALS AND METHODS: The analysis was based on the medical records of all patients diagnosed with COVID-19 and treated at the infectious diseases hospital of the Volgograd region in September 2020, March and September 2021, March, September and November 2022.
RESULTS: The odds of lethal outcome in COVID-19 patients ≥60 years of age within 60 days from admission were 6 times higher than in patients 60 years of age (odds ratio 6.21; 95% confidence interval 3.68–10.49). In 2022, the odds of lethal outcome in patients ≥60 years of age receiving antiviral drugs (remdesivir or favipiravir) were 64% lower compared to patients ≥60 years of age who did not receive any causal treatment (odds ratio 0.36; 95% confidence interval 0.20–0.69, p 0.05). The odds of hemorrhagic complications were higher among patients ≥75 years of age receiving anticoagulants compared to patients 60 years of age (odds ratio 5.99; 95% confidence interval 1.27–28.36).
CONCLUSIONS: Given the atypical forms of COVID-19 in the elderly, it is worth paying more attention to timely diagnosis and the prescription of etiotropic therapy, prevention of severe complications and conditions associated with death, and also more cautiously assessing the risks of prescribing anticoagulants due to the high incidence of side effects.
Assessing the influence of the angiotensinogen gene’s polymorphic marker M235T on the changes in daily blood pressure monitoring indicators in patients with stage I–II hypertension
Authors: Rebrova Ekaterina V. , Shikh Eugeniya V.
Published: January 2025

BACKGROUND: The effectiveness of antihypertensive therapy may be associated with genetic factors that both influence the degree of increase in blood pressure and determine inter-subject variability of response to antihypertensive treatment.
AIM: To study pharmacodynamic parameters of the effectiveness of therapy with angiotensin II receptor blockers as monotherapy and as part of combination drugs in patients with hypertension, depending on the genetic characteristics of patients, specifically the M235T polymorphism of the angiotensinogen gene.
MATERIALS AND METHODS: The study involved 179 patients from the Moscow region with newly diagnosed stage I–II hypertension, including 141 (78.8%) women and 38 (21.2%) men aged 32 to 69 years, who were randomly assigned to groups receiving irbesartan and valsartan as monotherapy or in combination therapy with hydrochlorothiazide, using a simple randomization method. Genetic polymorphism rs699 (C4072T, M235T) of the AGT angiotensinogen gene was determined after 3 weeks of drug therapy.
RESULTS: After three months of drug therapy, the maximum antihypertensive effect in the group of patients receiving valsartan was observed in CC homozygotes and heterozygotes by the level of decrease in mean daytime systolic blood pressure. In CC homozygotes, a trend was outlined by the level of decrease in mean daytime diastolic blood pressure; in CC homozygotes, by the level of decrease in mean nighttime systolic blood pressure; in CC and TT homozygotes, by the level of decrease in mean nighttime diastolic blood pressure. No statistically significant association of the angiotensinogen gene’s M235T polymorphism genotype with these parameters was found among patients receiving irbesartan.
CONCLUSIONS: The obtained data may indicate a more rapid and stable antihypertensive effect in patients carrying the C allele of the M235T genetic polymorphism of the angiotensinogen gene. Therefore, personalized therapy of arterial hypertension using the detection of the M235T genetic polymorphism in the AGT gene may reasonably include the AT1-receptor blocker valsartan as a starting therapy for the C allele carriers in the Moscow region, as monotherapy or two-component therapy, depending on the stage of hypertension.
The role of nitric oxide in the mechanisms of stress-protective action of low-intensity extremely high-frequency electromagnetic radiation in acute and chronic stress
Authors: Ravaeva Marina Yu. , Cheretaev Igor  V. , Chuyan Elena N. , Galenko-Yaroshevsky Pavel A. , Zelenskaya Anait V.
Published: January 2025

BACKGROUND: The study of stress mechanisms is an area of current interest in physiology and medicine. Understanding the role of nitric oxide (NO) in the mechanism of stress-protective action of low-intensity extremely high-frequency electromagnetic radiation (EHF EMR) requires investigating the main components of the stress response.
AIM: To determine the role of NO in the development of the anti-stress effect of low-intensity EHF EMR.
MATERIALS AND METHODS: 140 male Wistar rats weighing 200–220 g were divided into the following seven groups of 20 animals each: intact animals; AS, animals after a single exposure to acute stress; EHF-AS, animals irradiated with EHF EMR for 10 days and exposed to acute stress on day 10; L-NAME-EHF-AS, animals who were administered the NOS inhibitor L-NAME (10 mg/kg, intraperitoneally) for 10 days and irradiated with EHF EMR after 1 hour; HK, animals exposed to chronic hypokinetic stress for 10 days; EHF-HK, animals exposed to EHF EMR and hypokinetic stress for 10 days; L-NAME-EHF-HK, animals who were administered the NOS inhibitor L-NAME (10 mg/kg, intraperitoneally) for 10 days, irradiated with EHF EMR after 1 hour, and exposed to hypokinetic stress after another 1 hour. The levels of middle-weight molecules (MWM), circulating immune complexes (CIC), and malondialdehyde (MDA) were determined in the blood serum.
RESULTS: Acute stress increased the level of malondialdehyde, activating lipid peroxidation processes; in the EHF-AS group, this effect disappeared. NO blockade in the L-NAME-EHF-AS group activated endotoxication processes, the stress cascade, and physiologically active regulatory peptides (increase in the MWM level at 280 nm), oxidative metabolism of proteins and lipids (increase in the CIC and MDA levels), and inhibited immunogenesis. Hypokinetic stress suppressed the stress inhibiting system of the body and physiologically active regulatory peptides (decrease in the MWM level at 280 nm), suppressed immunogenesis, and increased oxidative metabolism of proteins and lipids (increase in the CIC and MDA levels). The stress-protective effect of EHF EMR was observed in the EHF-HK group. NO blockade in the L-NAME-EHF-HK group activated endotoxication processes, stress cascade and stress inhibiting systems of the body, physiologically active regulatory peptides (increase in the MWM level at 254 and 280 nm), oxidative metabolism of proteins and lipids (increase in the CIC and MDA levels), and inhibited immunogenesis.
CONCLUSIONS: NO blockade with L-NAME amplifies the effects of acute and hypokinetic stress under the exposure to low-intensity EHF EMR. Normal NO levels are necessary for the stress-protective effect of EHF EMR to develop during acute and hypokinetic stress.
Varicella (chickenpox) has “matured” and become even more dangerous
Authors: Neverov Vladimir A. , Kirpichnikova Galina I. , Antonov Vsevolod M. , Startseva Galina Yu. , Klur Margarita V.
Published: January 2025

This lecture focuses on varicella (chickenpox), one of the highly contagious diseases, the outbreaks of which can be effectively prevented through vaccination. It highlights modern aspects of the etiology, pathogenesis, epidemiology, clinical presentation, diagnosis, treatment, and prevention of varicella. Additionally, the lecture explores the clinical diversity of the disease’s forms and complications, including cases in newborns with perinatal infection. Compelling evidence characterizes varicella as a severe and “non-benign” infectious disease, which ranks among the leading causes of economic losses associated with infectious diseases in Russia.
The “maturation” of varicella observed in recent years has led to serious consequences, including more severe complications in adults compared to children, an increased economic burden, and a rising number of cases among pregnant women, resulting in higher rates of congenital and neonatal varicella. In light of increasing varicella incidence in Russia and several other countries, the data presented in this lecture are particularly valuable for practicing physicians, especially family doctors.
Clinical and laboratory characteristics of patients with severe COVID-19 undergoing gene engineering therapy
Authors: Rogozhkina Aleksandra V. , Pogromskaya Margarita N. , Romanova Elena S. , Startseva Galina Yu. , Filipovich Olga M. , Klur Margarita V. , Antonov Vsevolod M.
Published: January 2025

Background: One of the primary factors contributing to an increased risk of fatal outcomes in severe COVID-19 cases is the development of a cytokine storm, a hyperimmune response characterized by excessive cytokine release. Despite using biologic therapies, mortality rates in severe COVID-19 cases remain significantly high.
Aim: To analyze and evaluate the clinical and laboratory parameters of patients with severe COVID-19 who received biologic therapy.
Materials and methods: A cluster sampling method was employed, with clusters selected based on the severity of the primary disease and biologic therapy. The study included 65 patients, divided into two groups based on disease outcomes: Group 1 comprised 34 patients with favorable outcomes, while Group 2 included 31 patients with fatal outcomes.
Results: Significant differences were observed between the groups in terms of age (p = 0.01). Patients in Group 2 (with fatal outcomes) had a higher burden of co-morbidities, as measured by the Charlson Comorbidity Index (p = 0.00009) and the Cumulative Illness Rating Scale for Geriatrics (CIRS-G; p = 0.000003). Additionally, the groups differed significantly in the number of days from disease onset to the initiation of biologic therapy (p = 0.02). In Group 2, delayed initiation of biologic therapy was associated with persistently high concentrations of acute-phase proteins.
Conclusions: Key factors influencing the efficacy of biologic therapy for severe COVID-19 with cytokine storm include patient age, the presence and severity of co-morbidities, and the timing of hospitalization and initiation of biologic therapy.