bluuebunny/crossref_metadata_2025 huggingface dataset:
Thai herbal extracts from Garlic and Turmeric suppress the type 3 secretion system of Salmonella Typhimurium
Authors: Thinwang Patipat , Samakchan Natthapon , Boonyom Rerngwit
Published: April 2023

Introduction: In Thailand, garlic and turmeric have been used widely as basic spices in Thai food and traditional medicine. Previous studies reported that both of them had antibacterial activities. A few data have shown that extracts from both herbs are type 3 secretion system (T3SS) inhibitors. Therefore, this study aimed to investigate anti-T3SS in garlic and turmeric extracts and identify their specific mechanisms. Methods: Salmonella Typhimurium containing chromosomally infusion between the gene encoding SipA effector protein and strep-tag epitope was used for the determination of anti-T3SS in garlic and turmeric extracts. The mechanism of inhibition was identified by the determination of mRNA expression of T3SS genes with semiquantitative RT-PCR. Results: Garlic and turmeric extracts contained T3SS inhibitory activity at the concentrations of 100 μg/mL and 75 μg/mL, respectively. These extracts reduced the ability of bacterial invasion into epithelial cell cultures. However, the effective dose of both extracts did not affect bacterial growth or toxic effects on HeLa cells. Moreover, the results from RNA transcriptional levels illustrated that these extracts suppressed the transcription of the T3SS regulation genes. Conclusion: It may conclude that garlic and turmeric extracts blocked T3S activity for the secretion of effector proteins and bacterial invasion by interfering the expression of the T3SS regulatory cascade. Therefore, the extracts from garlic and turmeric might be potential sources for the development of new anti-T3SS therapeutic agents.
Potent anticancer effects of vitamin C and vitamin C-rich fruit extract (Citrus sinensis L.) on human lung cancer cells
Authors: Kamranikheiri Mohaddeseh , Kosar Muberra
Published: April 2023

Introduction: Studies have shown that synthetic agents are connected with some complications. This work was designed to study the effects of vitamin C and Citrus sinensis fruit extract (CSFE) on viability, DNA synthesis, and apoptosis stimulation in human lung cancer cells (COR-L105). Methods: The total contents of the phenolics, flavonoids, and ascorbic acid in CSFE were assessed through the Folin-Ciocalteu, aluminum chloride, and dinitrophenyl hydrazine methods, respectively. The cytotoxicity of vitamin C and CSFE on COR-L105 cells was evaluated by the cell viability assay. Measurement of the DNA synthesis was done through the BrdU solution assay. The expression levels of some apoptosis regulatory genes were also evaluated. Results: The total phenolic, flavonoids, and ascorbic acid contents of CSFE were 94.31 ± 2.27 gallic acid equivalents (mg/g) of dry extract, 63.26 ± 2.86 quercetin equivalents (mg/g) of dry extract, and 59 mg/L, respectively. The 50% cytotoxicity concentration (CC50) values of vitamin C and CSFE on cancer cells were 54.6 and 82.7.6 μg/mL, respectively. Vitamin C and CSFE dose-dependently declined the amount of DNA production in the cancer cells. The expression levels of caspase-3 and Bax genes were markedly (P < 0.001) elevated by vitamin C and CSFE, while they reduced the level of Bcl-2 gene (P < 0.05). Conclusion: The findings showed the potent anticancer effects of vitamin C and CSFE against human lung cancer cell lines. DNA synthesis reduction and apoptosis induction can be considered as possible mechanisms of action. However, further surveys are necessary to clarify the accurate mechanism and their efficacy.
Protective role of hispolon pyrazole and hispolon monomethyl ether pyrazole in electromagnetic radiation-induced behavioral, neurochemical, oxidative, and histological changes in rats
Authors: Saka Vara Prasad , Vellapandian Chitra , Narayanasamy Damodharan
Published: April 2023

Introduction: Radiofrequency electromagnetic radiation (RF-EMR) from mobile phones was reported to cause neurological damage. Hispolon pyrazole (HP) and hispolon monomethyl ether pyrazole (HMEP) were tested for their RF-EMR protection in rats. Methods: Juvenile Wistar albino rats were exposed to the mobile phone generating 2400 MHz radiation with a maximum power output of 2 W/kg (Specific absorption rate 1.6 W/kg) for 90 days at a rate of 2 hours/day, treated with HP and HMEP at 20 and 40 mg/kg body weight. The elevated plus maze (EMT) test was used for anxiety and exploration evaluation, the forced swim test (FST) for depression, the Morris water maze test and Y-maze test for learning and memory. The oxidative stress markers like glutathione, superoxide dismutase (SOD), catalase (CAT), and malonaldehyde (MDA), and the neurotransmitters such as gamma-aminobutyric acid, glutamate, dopamine, and acetylcholinesterase along with histopathology in the cortex, striatum, and hippocampus were evaluated to establish the mechanism of the neuronal alterations of HP and HMEP against RF-EMR-induced damage. Results: In the current investigation, HP at a higher dose of 40 mg/kg and HMEP at both doses significantly reduced the oxidative stress generated by RF-EMR from mobile phones and altered neurobehavioral, neurotransmitter, and histological alterations. Conclusion: Based on the findings, HP and HMEP at a dose of 40 mg/kg are protective agents against long-term, continuous mobile phone use and can be regarded viable therapeutic agents.
Antiparasitic effect of limonene, a monoterpene compound found in the essential oils against Giardia lamblia
Authors: Kharazmkia Ali , Ghasemian Yadegari Javad , Mohammadian Mohammad , Ali Rehman , Mahmoudvand Hossein
Published: April 2023

Introduction: The present work aimed to assess the anti-parasitic effects of limonene (LMN) against Giardia lamblia trophozoites and cysts. Methods: Anti-Giardia activities of LMN (25, 50, and 100 μg/mL) were assessed against G. lamblia cysts and trophozoites for 15-360 minutes. The effects of LMN on the apoptosis stimulation G. lamblia parasites were determined by colorimetric protease assay. Results: Giardia trophozoites were more sensitive to LMN than cysts. The best effect of LMN was seen at 100 μg/mL. LMN markedly triggered caspase-3 activity by 10.2%, 25.3%, and 36.1%, respectively (P < 0.001). Conclusion: We found the potent in vitro anti-giardia activity of LMN against G. lamblia parasites with the maximum activity at 50 and 100 μg/mL. However, additional surveys are necessary to reveal the specific efficacy, mechanisms, and safety of LMN.
Effect of Er: YAG Laser Irradiation on Bone Metabolism-Related Factors Using Cultured Human Osteoblasts
Authors: Tsuka Yuji , Kunimatsu Ryo , Gunji Hidemi , Sakata Shuzo , Nakatani Ayaka , Oshima Sho , Rikitake Kodai , Aisyah Purtranti Nurul , Kado Isamu , Ito Shota , Tanimoto Kotaro
Published: April 2023

Introduction: A variety of laser treatments have been applied in numerous medical fields. In dentistry, laser treatments are used for caries, root canals, and periodontal disease, as well as surgical resection. Numerous reports have recently been published on the use of lasers for bone regeneration. If laser irradiation is found to promote the activation of bone metabolism, it might also be effective for periodontal treatment, peri-implantitis, and bone regeneration. Therefore, the present in vitro study aimed to elucidate the mechanisms underlying the effects of erbium-doped yttrium aluminum garnet (Er: YAG) laser irradiation on the bone using osteoblast-like cells. Methods: Osteoblast-like Saos 2 cells (5.0×104 cells) were seeded in 24-well plates. 24 hours after being seeded, the cells were subjected to 0.3 W, 0.6 W, and 2.0 W Er: YAG laser irradiation and then allowed to recover for 48 hours. The expression levels of bone metabolism-related factors alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteoprotegerin (OPG) were then evaluated using reverse transcription–quantitative polymerase chain reaction and western blot analyses. Results: Saos 2 cells subjected to Er: YAG laser irradiation at 0.3 W, 0.6 W, and 2.0 W showed normal growth. When the Er: YAG laser irradiation and control groups were compared after 48 hours, increases were observed in ALP, BSP, and OPG gene and protein expression in the 2.0 W group. Similar results were obtained in the western blot analysis. Conclusion: These findings suggest that the Er: YAG laser irradiation of osteoblast-like cells is effective for activating bone metabolism factors.
The effect of a mobile-based self-care program on tremor of people with multiple sclerosis
Authors: Safian Abbas , Davoodvand Shirmohammad , Sedehi Morteza , Tahmasebian Shahram , Jivad Nahid
Published: April 2023

Background and aims: Multiple sclerosis (MS) is one of the most common progressive neurological diseases in young people. Tremor is a common and debilitating symptom in people with MS, significantly affecting their quality of life. This study aimed to evaluate the effect of a self-care program based on a mobile application on tremors in people with MS. Methods: This semi-experimental study was conducted on 72 patients with MS in Chaharmahal and Bakhtiari province in 2019. Samples were selected by convenience sampling and randomly assigned to intervention and control groups (36 people in each group). For the intervention group, a self-care program in the form of a mobile application was installed on their mobile phones and, for two months, used by patients. The use of the program was measured using self-report checklists and telephone tracking. The control group receives routine intervention only. Data were collected before and two months after the intervention using the Fahn-Tolosa-Marin Tremor Rating Scale and analyzed using SPSS software version 21 and descriptive and inferential statistics (chi-square, independent t test, and paired t test). Results: There was no statistically significant difference between the two groups in the mean tremor score before the intervention (P=0.768). However, after the intervention, this difference was significant (P=0.022). Conclusion: According to the findings, teaching a self-care program through a mobile application effectively improves the tremor of patients with MS and can be considered an effective intervention method.
The effect of nursing ethics education through narration and lecture methods on patient advocacy by nurses in Iran in 2017: A quasi-experimental study
Authors: Imanifar Nasrin , Derikvand Milad , Vagharseyyedin Seyyed Abolfazl
Published: April 2023

Background and aims: Patient advocacy role in nursing is affected by several barriers, such as the lack of nurses’ ethical knowledge about their roles as patient advocators. Since this role can be learned, these barriers may be overcome by education through an effective method. The present study aimed to investigate the effect of ethics education on nurses’ patient advocacy using ethics narration and lecture compared to a control group. Methods: This quasi-experimental, three-group design study was conducted among nurses of hospitals in Birjand, South Khorasan province in 2016-2017. The sample size (n) was 27 in the narration group, 26 in the lecture group, and 22 in the control group. We used the Protective Nursing Advocacy Scale (PNAS) developed by Hanks to collect data, whose validity and reliability have been confirmed in Iran. Data analysis was performed using a trial version of SPSS 22 by descriptive and analytical statistics appropriate to the research objectives. Results: The results of comparing the three groups after eliminating the effect of age indicated that lecture-based education increased the total patient advocacy (P<0.05) and the impact of education and environment (P<0.05) significantly compared with the control group. However, the narration method did not show any significant difference to the control group. Conclusion: The lecture and narration methods increased nurses’ patient advocacy. We recommend combining the two methods to achieve better outcomes.
Knowledge, attitude, and practices regarding COVID-19 among college-degree students in Southern district of India
Authors: Narasimha Bellagolla Changalarayappa , Udayar Sharavanan Eshwar , Kumar Kruthika Kishore , Ashwini Madeshan
Published: April 2023

Background and aims: A case of coronavirus disease 2019 (COVID-19) was identified first in Wuhan, China in December 2019. To prevent the rampant spread of COVID-19, the behavioral change of people was crucial. This study aimed to determine the knowledge, attitude, and practice (KAP) toward COVID-19 among college-degree students in the southern district of India. Methods: A cross-sectional, online study was conducted from January to February 2021 among 400 college-degree students. Snowball sampling technique was adopted for collecting data using a semi-structured questionnaire. Data were entered in Excel and analyzed using Epi Info version 7.2. Results: Out of 400 participants, 107 (26.75%) were male and 293 (73.25%) were female. Out of all the men in the study, 107 (100%) had good knowledge regarding COVID-19 infection, whereas 276 (94.2%) of women had good and 17 (5.8%) had average knowledge (P<0.01). A total of 262 (89.4%) and 31 (10.6%) women had a positive attitude and neutral attitude toward COVID-19 infection, respectively, whereas in men, the majority (86, 80.4%) had a positive, followed by (14, 13.1%) negative and (7, 6.5%) had neutral attitude (P<0.001). All the students 400 (100%) had good practice 400 (100%) regarding COVID-19 infection. Conclusion: The male students had better knowledge about COVID-19 infection, but the positive attitude towards COVID-19 was higher among women. The practice regarding COVID-19 infection was satisfactory among all the students.
Prediction of health-related quality of life through health literacy, perceived social support, spiritual well-being, and resilience in patients undergoing hemodialysis: An artificial neural network study
Authors: Hassani Fatemeh , Gholamzadeh Jofreh Maryam , Zarea Kourosh , Dashtebozorg Zahra , Chan Sally Wai-Chi
Published: April 2023

Background and aims: An important factor for determining the efficacy of treatment for patients under hemodialysis is the health-related quality of life (HRQOL). This study aimed to examine the predictor of HRQOL among hemodialysis (HD) patients based on spiritual well-being (SWB), perceived social support (PSS), health literacy (HL), and resilience. Methods: The present correlational study was performed on 260 patients randomly selected from the teaching hospitals of Ahvaz Jundishapur University of Medical Sciences. Data collection tools were a 36-item HRQQL questionnaire, Paloutzian & Ellison SWB scale, Zimet PSS scale, the Connor and Davidson resilience scale, and Montazeri and colleagues’ HL for Iranian adults. Python software was used to conduct data analysis. Descriptive statistics, feedforward, and backpropagation algorithm in an artificial neural network (ANN) was used to determine the effect of studied variables on HRQOL. Results: The mean age of patients was 51.73±15.32 years. Most of the patients were married (76.9%), had low-income level (55%), and had at least one comorbidity (59.2%). The mean duration of hemodialysis machine use was 5.06±3.43 years. Studied variables had grater impact on Physical QOL than the mental QOL. It was revealed that two dimensions of HL included evaluation skills (accuracy 0.92), accessibility skills (accuracy 0.92), and PSS (accuracy 0.88) were stronger predictors of physical QOL than other variables and SWB in the existence dimension (accuracy 0.80), understanding skills of HL (accuracy 0.76) and evaluation skills of HL (accuracy 0.75) were stronger predictors of mental QOL that other variables. Conclusion: To improve the HRQOL of HD patients, we should increase HL, support social relationships, and improve meaning in life by giving importance to the SWB of these patients in providing care services to them.
Perception of medical-surgical wards’ patients from safety culture: A cross-sectional and multicenter study
Authors: Vaezi Maryam , Amini Kourosh , Ghahremani Zeinab
Published: April 2023

Background and aims: Identifying the strengths and weaknesses of safety culture in hospitals can be the basis for developing plans to improve the safety status of patients. This study aimed to determine the level of patient safety culture (PSC) from their view in medical-surgical wards of five teaching hospitals in Zanjan. Methods: This cross-sectional study was performed on 245 patients admitted to medical-surgical wards of five teaching hospitals in the Zanjan, Iran, from 2020-Agust-22 to 2020-November-21. Poisson time sampling method was used. Data collection was performed using a demographic information questionnaire and PSC scale. The data were analyzed using SPSS 18 and descriptive statistics, independent t test, and one-way analysis of variance. Results: The mean of total PSC was 3.63±0.60 out of 5. The highest mean of PSC was related to organizing and planning for care (3.87±0.71) and communication and teamwork (3.80±0.70). The lowest mean was related to information dissemination (3.31±0.60). Conclusion: Safety culture or, in other words, patients’ perception of the safety situation prevailing in studied wards and hospitals was moderate. Therefore, it needs to be upgraded and improved. Among the various dimensions of patient-perceived safety, the manner and extent of information sharing was worse. It is suggested that plans be made to direct actions to improve the patient’s safety culture in general and in the field of information dissemination in particular.
Case series of low dose rituximab for membranous nephropathy; a single centre experience
Authors: Mathew Gerry George , Varadharajan Jayaprakash , Sailapathy Sreedhar
Published: April 2023

Introduction: Rituximab is the recent treatment of choice for primary membranous nephropathy However, dose of rituximab mentioned in literature is high and not economical in middle income countries. Low dose rituximab based on CD 19 cell count can be tried as an alternative for high dose rituximab for inducing clinical remission in appropriate clinical settings. Case Series: Four patients were administered low dose rituximab and initial CD 19 count was monitored for optimal rituximab response. Three males and one female are part of this case series. Renal biopsies showed membranous nephropathy with tissue phospholipase A2 receptor (PLA2R) positivity in two cases. Serum PLA2R was positive for the same two cases. Two patients completely remitted after one year, one male patient required additional rituximab dose based on CD19 count, one patient required single dose of rituximab for partial remission in the background of tacrolimus with steroids. One patient failed to remit on low dose rituximab protocol. Conclusion: Low dose Rituximab can be tried as a favorable alternative for high dose Rituximab in appropriate clinical settings.
Role of hyperuricemia in cardiovascular disease and its treatment options: A review article
Authors: Kafi Fatemeh , Yousefi Pourya , Bakhshaei Sina , Pouramini Alireza , Bakhshaei Bina , Reddy SriVaibhav , Reddy Krishina Theja
Published: April 2023

Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity worldwide. Several studies highlighted the association of CVD with hyperuricemia. We searched PubMed, EMBASE, Scopus, and DOAJ with the following keywords, including hyperuricemia and cardiovascular disease, to address these topics: 1) mechanism of hyperuricemia 2) relationship of hyperuricemia with cardiovascular disease 3) Treatment of hyperuricemia
Current status and perspectives of ultrasound-guided ablation techniques in patients with primary hyperparathyroidism
Authors: Jafari Mohsen , Rastegar-Kashkouli Ali , Yousefi Pourya , Khavaran Ashkan , Sharifi Mohammad , Baradaran Azar , Yousefi Pedram , Rastegar Dordaneh
Published: April 2023

Primary hyperparathyroidism (PHPT) is an endocrine disorder characterized by elevated or inappropriately parathormone levels. The most common cause of PHPT is solitary parathyroid adenoma (80-85%). Parathyroid surgery generally encompasses symptomatic PHPT and asymptomatic patients who meet the surgical guideline criteria. If surgery is contraindicated, several non-surgical ablative techniques can be conducted to eliminate the pathological parathyroid tissue, which causes tissue necrosis in the affected gland. This review aims to look into the most recent studies on the efficacy of percutaneous ethanol injection therapy (PEIT), laser ablation (LA), radiofrequency ablation (RFA), microwave ablation (MWA), and high-intensity focused ultrasound (HIFU) in treatment of PHPT and analyze their application prospects. PEIT is a classic method that is less commonly used nowadays. The analysis of thermal ablation methods revealed that LA is inefficient and requires considerable repetition. Meanwhile, the MWA and RFA have a cure rate of over 85% and fewer complications; it seems that they have the potential to replace surgical methods in the future.
Serum uric acid-reduction and blood pressure changes in allopurinol administered hemodialysis patients; a pilot study
Authors: Mardani Saeed , Mardanparvar Hossein , Momenzadeh Mahnaz , Nourbakhsh Rezaiee Seyedeh Fatameh , Hajian Mohammad Reza
Published: April 2023

Introduction: Hypertension is one of the most common diseases and is the main cause of disability and mortality worldwide. Hyperuricemia has been recognized as one of the main causes of hypertension; however, few studies have been conducted to determine the correlation between serum uric acid reduction and blood pressure changes. Objective: This study aimed to assess the correlation between serum uric acid-reduction and blood pressure changes in a group of hemodialysis patients. Patients and Methods: This descriptive-analytical study was conducted on 21 hemodialysis patients taking allopurinol for the first time. Serum uric acid, systolic blood pressure, and diastolic blood pressure were measured before taking allopurinol, then patients were followed for two months, and these parameters were remeasured. Data were collected and the correlation between serum uric acid-reduction and blood pressure changes was evaluated. Results: Most patients were female, with a mean age of 56.81 ± 15.59 years. Results showed that the correlation between serum uric acid reduction and blood pressure changes was statistically significant with a ratio of 3.6 reduction for systolic blood pressure and 2.17 for diastolic blood pressure per one unit of uric acid reduction (P<0.05). Conclusion: Uric acid reduction is correlated with blood pressure reduction with both systolic and diastolic blood pressures.
Is furosemide a nephrotoxic for hospitalized patients?
Authors: Hoe Kyaw Kyaw , Rowe-Gardener Swane , Hoe Thant Hnin Saint
Published: April 2023

Introduction: Acute kidney disease (AKI) is preventable in certain situations. Long-term and/or high dose furosemide may lead to acute kidney injury. Objectives: We aimed to find the risk of AKI among hospitalised patients who were exposed to furosemide. Patients and Methods: This is a retrospective cohort study of hospitalised patients who received furosemide therapy during the admission between 2019 and 2021. Exposure to furosemide was grouped into low dose (≤ 40 mg/d) or high dose (>40 mg/d) and short-term use (≤ 72 hours) or long-term use (>72 hours). Risk of acute kidney injury was calculated as odds ratios with a 95% confidence interval (CI). A P value <0.05 was considered statistically significant. Results: Of 314 patients who received furosemide intravenously or orally, 197 patients (62.7%) had acute kidney injury. Of 197 patients with acute kidney injury, 110 patients (55.9%) received the dosage of >40 mg/d and 121 patients (61.4%) were on furosemide for >7 days (odds ratios [ORs]: 5.46, 95% CI: 3.17 to 9.39, P≤0.001 and ORs: 7.72, 95% CI: 4.4 to 13.52, P≤0.001). In comparison, the 87 (44.1%) patients who received ≤40 mg/d of furosemide had a lower incidence of AKI (ORs: 0.25, 95% CI: 0.13 to 0.48, P≤0.001) and only 21 of the patients (10.6%) who received furosemide for < 7 days were found to have acute kidney injury (ORs: 0.08, 95% CI: 0.04 to 0.14, P≤0.001). The combined effect of high dose and long-term furosemide therapy is more consequential as we found that 100 (31.8%) patients who received furosemide >40 mg for >72 hours, 96 patients (30.6%) developed AKI (ORs: 26.8, 95% CI: 9.53 to 75.63, P≤0.001). Conclusion: Among hospitalised patients, exposure to high dose furosemide or prolonged use of furosemide is associated with AKI. The risk is more when high dose furosemide is administered for longer than 72 hours. Presence of underlying diabetes, hypertension, cardiac failure and chronic kidney disease, are also associated with furosemide -induced hospital-acquired acute kidney injury.
Predictive risk factors of steroid dependent nephrotic syndrome in children with idiopathic nephrotic syndrome
Authors: Valavi Ehsan , Nickavar Azar , Amoori Parisa , Fathi Mohsen , Valavi Bahareh
Published: April 2023

Introduction: Steroid dependent nephrotic syndrome (SDNS) is a difficult and troublesome presentation of idiopathic nephrotic syndrome (INS) in children, with complicated management and increased morbidity. Objectives: The aim of this study was to identify the predictive clinical and laboratory characteristics of patients with SDNS, for parents counseling, appropriate management and improving outcome. Patients and Methods: A total of 374 children with steroid sensitive INS were evaluated in two groups as steroid dependent (group 1=199) and non-steroid dependent (group 2= 175) INS. SDNS was defined as ≥2 relapses during steroid reducing treatment or 15 days after discontinuation of corticosteroids. Results: Mean age at presentation was significantly lower in children with SDNS than those without steroid dependency (P=0.022). Diagnostic age less than two years (P=0.016), total relapses (P<0.001), relapse/year (P<0.001), body mass index (BMI) (P=0.002) and serum cholesterol level (P=0.042) were significantly higher in children with SDNS, compared to those with low-frequent relapse. Mean relapse rate decreased significantly in SDNS with immunosuppressive treatment (P<0.001). Conclusion: Age younger than two years at diagnosis, high BMI, high relapse rate/year and hypercholesterolemia at remission are suggested as predictors of SDNS in children with INS.
Cancer recurrence or aggravation following COVID-19 vaccination
Authors: Soleimani Parisa , Yadollahifarsani Sepideh , Motieian Mahsa , Chenarani Moghadam Mahshid Sadat , Alimohammadi Shahrzad , Khayyat Azadeh , Esmaeil Pour Mohammad Ali , Neshat Sina , Marashi Narges Alsadat , Mahmoodnia Leila , Masomi Rohollah
Published: April 2023

COVID-19 infection has been a global health issue in the past recent years and numerous topics are studied in order to discover its pathophysiology and potential side effects. The potential for disease recurrence following the administration of the COVID-19 vaccine is one of the issues that has recently attracted attention. Several studies have revealed that the COVID-19 vaccines, like other vaccines, may have side effects and, in some cases, they may even deteriorate the underlying illnesses, such as rheumatic diseases, autoimmune diseases, and cancers. The effectiveness and safety of the COVID-19 vaccine for patients with malignancies are one of the factors that are considered regarding this vaccine. Lymph node involvement, disease recurrence, and potential paraclinical changes after receiving the COVID-19 vaccine are some of the concerns of patients with malignancy. In this mini-review, we attempted to investigate cases of cancer recurrence or recovery as well as lymphadenopathy following vaccination.
A Combination of Data Augmentation Techniques for Mango Leaf Diseases Classification
Authors: Faye Demba , Diop Idy , Mbaye Nalla , Dione Doudou
Published: April 2023

Mango is one of the most traded fruits in the world. Therefore, mango production suffers from several pests and diseases which reduce the production and quality of mangoes and their price in the local and international markets. Several solutions for automatic diagnosis of these pests and diseases have been proposed by researchers in the last decade. These solutions are based on Machine Learning (ML) and Deep Learning (DL) algorithms. In recent years, Convolutional Neural Networks (CNNs) have achieved impressive results in image classification and are considered as the leading methods for image classification. However, one of the most significant issues facing mango pests and diseases classification solutions is the lack of availability of large and labeled datasets. Data augmentation is one of solutions that has been successfully reported in the literature. This paper deals with data augmentation techniques namely blur, contrast, flip, noise, zoom and affine transformation to know, on the one hand, the impact of each technique on the performance of a ResNet50 CNN using an initial small dataset, on the other hand, the combination between them which gives the best performance to the DL network. Results show that the best combination classifying mango leaf diseases is ‘Contrast & Flip & Affine transformation’ which gives to the model a training accuracy of 98.54% and testing accuracy of 97.80% with an f1_score > 0.9.
Any Teacher can be a Counsellor: Role of Teachers in Guidance and Counselling
Authors:   Librarian, Thiagarajar College of Preceptors (Aided), Madurai, Sundar N. , Sophia Mesalia P. ,   Assistant Professor of Education, Thiagarajar College of Preceptors (Aided), Madurai
Published: April 2023

The main purpose of this paper is to identify the primary counselling ideas and skills for responding to students’ psychological, emotional, and developmental issues. The essential characteristics of a teacher are trustworthy, good listener, empathetic and caring in nature. Teacher can motivate the pupils to direct their devotion towards educational tasks by providing group counselling. It is a teacher's great responsibility to provide right study materials to succeed in their studies. Special guidance and counselling required for those who is lacking concentration, poor grades and facing personal problems. Higher secondary and college students need experts counselling to higher education in India and abroad for choosing right subject at right institutions.
Meta Cognition of B.Ed. Student in Relation to their Decision Making in Virudhunagar District
Authors:   Assistant Professor of Mathematics, Thiagarajar College of Preceptors, Madurai, Anbalagan S.
Published: April 2023

The goal of this study is to determine the importance of differences in Meta Cognition of B.Ed. Student in relation to their Decision Making in Virudhunagar District. The sample was drawn from the Virdhunagar district B.Ed. College students and was fitted with the normative survey approach. The investigator chose a sample from the population using a basic random sampling approach. A total of 300 B.Ed. students from Viurdhunar District were included in the study. The finding of result revels that there is significant difference between male and female B.Ed. college students in their meta cognition. The finding present study shows that there is significant difference between rural and urban college students in their metacognition. Rural B.Ed. students. The finding of result revels that There is significant relationship between metacognition and decision-making B.Ed. students. A very high (positive) linear relationship between metacognition and decision-making B.Ed. students.
Hashimoto’s Encephalopathy: A Literature Review and Own Clinical Observation
Authors: Костюкевич Е.П. , Рушкевич Ю.Н. , Лихачев С.А. , Клюнчик С.Г. , Гвищ Т.Г.
Published: April 2023

Энцефалопатия Хашимото представляет собой редкий нейроэндокринный синдром и является вариантом энцефалопатии аутоиммунной этиологии, ассоциированной с выработкой антитиреоидных антител. Заболевание может встречаться в любом возрастном периоде, средний возраст дебюта составляет 44 года, 20% случаев приходится на лиц моложе 18 лет. Женщины болеют в 4 раза чаще. Заболевание встречается редко, недостаточно изучено, отличается трудностями диагностики, динамичностью клинических симптомов и их обратимостью в ответ на иммуносупрессивную терапию глюкокортикостероидами (ГКС). Сложность диагностики энцефалопатии Хашимото связана с особенностями течения и полиморфизмом клинических симптомов, которые могут имитировать картину различных неврологических и психиатрических расстройств. Тем не менее своевременно установленный диагноз позволяет эффективно провести иммуносупрессивную терапию и быстро купировать симптомы заболевания, в том числе угрожающие жизни пациента. Обратимость симптоматики заболевания в ответ на терапию ГКС свидетельствует о развитии особых, скорее функциональных, чем грубых, органических нарушений в нервной системе. Назначение в адекватных дозировках ГКС позволяет быстро купировать симптомы энцефалопатии Хашимомто, достичь полного регресса психоневрологических расстройств, а также обусловливает хороший долгосрочный прогноз. Авторы представили обзор литературы и собственное клиническое наблюдение энцефалопатии Хашимото у пациентки 50 лет.

Hashimoto’s encephalopathy is a rare neuroendocrine syndrome being a variant of autoimmune encephalopathy associated with the production of antithyroid antibodies. The disease can occur in any age period, the average age of onset is 44 years, in 20% of cases it occurs in persons under 18 years of age. Women get sick 4 times more often. The disease is rare, insufficiently studied, and characterized by diagnostic difficulties, clinical symptoms dynamics, and their reveфrsibility in response to immunosuppressive therapy with glucocorticosteroids (GCS). The difficulty in diagnosing Hashimoto’s encephalopathy is associated with peculiarities of its course and polymorphism of clinical symptoms, which can imitate pictures of various neurological and psychiatric disorders. Nevertheless, a timely diagnosis allows effective immunosuppressive therapy and rapid relief of symptoms, including life-threatening ones. The reversibility of disease symptoms in response to GCS therapy indicates special, rather functional, than rough, organic disorders in the nervous system. Prescribing GCS in adequate dosages allows quickly relieving Hashimoto’s encephalopathy symptoms, achieving a complete regression of neuropsychiatric disorders, and also determines a good long-term prognosis. The authors presented a literature review and their own clinical observation of Hashimoto’s encephalopathy in a 50-year-old female patient.
Gestão da Qualidade e Segurança dos Alimentos. V. 3
Authors: Capistrano Camurça Portela Masu , Arrais Jales Katiane , Portela Pereira Júlio Otávio
Published: April 2023

O objetivo principal desta obra é servir como fonte de estudo e consulta, tanto para os estudantes no âmbito das áreas de alimentos, como para profissionais da saúde, com enfoque mais didático, científico e atual. Poderá ser utilizado em diversos estabelecimentos que envolvam manipulação de alimentos: restaurantes, lanchonetes, hospitais, hotéis, escolas, creches, aeroportos até mesmo ambientes domiciliar. Os profissionais convidados para escreverem os doze capítulos foram escolhidos por seus relevantes trabalhos em suas respectivas especialidades na área de Segurança Alimentar e Nutricional, encontrando-se aptos a abordar com profundidade os temas discorridos. Dessa forma, os temas abordados serão de grande valia para os leitores que buscam garantir a qualidade dos seus serviços visando a saúde, através de alguns aspectos como ingestão, absorção, excreção adequados de todos os alimentos a serem consumidos.
Boas práticas na manipulação de alimentos em um cenário pandêmico da covid-19: uma revisão de literatura
Authors: Pereira de Oliveira Taline , de Lima Pinheiro Francisca Gabriela , Lima de Araújo Paolo Germanno , da Silveira Queiroz Herlene Greyce
Published: April 2023

O objetivo principal desta obra é servir como fonte de estudo e consulta, tanto para os estudantes no âmbito das áreas de alimentos, como para profissionais da saúde, com enfoque mais didático, científico e atual. Poderá ser utilizado em diversos estabelecimentos que envolvam manipulação de alimentos: restaurantes, lanchonetes, hospitais, hotéis, escolas, creches, aeroportos até mesmo ambientes domiciliar. Os profissionais convidados para escreverem os doze capítulos foram escolhidos por seus relevantes trabalhos em suas respectivas especialidades na área de Segurança Alimentar e Nutricional, encontrando-se aptos a abordar com profundidade os temas discorridos. Dessa forma, os temas abordados serão de grande valia para os leitores que buscam garantir a qualidade dos seus serviços visando a saúde, através de alguns aspectos como ingestão, absorção, excreção adequados de todos os alimentos a serem consumidos.
Proposta de metodologia de troca rápida de ferramentas (TRF) para indústria de massas e biscoitos
Authors: Roca Menezes Eric , Teles César Leiliane , da Silveira Queiroz Herlene Greyce , e Silva Rafael Victor , Lima de Araújo Paolo Germanno
Published: April 2023

O objetivo principal desta obra é servir como fonte de estudo e consulta, tanto para os estudantes no âmbito das áreas de alimentos, como para profissionais da saúde, com enfoque mais didático, científico e atual. Poderá ser utilizado em diversos estabelecimentos que envolvam manipulação de alimentos: restaurantes, lanchonetes, hospitais, hotéis, escolas, creches, aeroportos até mesmo ambientes domiciliar. Os profissionais convidados para escreverem os doze capítulos foram escolhidos por seus relevantes trabalhos em suas respectivas especialidades na área de Segurança Alimentar e Nutricional, encontrando-se aptos a abordar com profundidade os temas discorridos. Dessa forma, os temas abordados serão de grande valia para os leitores que buscam garantir a qualidade dos seus serviços visando a saúde, através de alguns aspectos como ingestão, absorção, excreção adequados de todos os alimentos a serem consumidos.
Construção de um plano de contingência para restaurante hospitalar em período pandêmico (sars-cov-2)
Authors: Souza da Silva Katia , da Silveira Queiroz Herlene Greyce , Elmiro Timbó Francisca Joyce , Lima de Araújo Paolo Germanno
Published: April 2023

O objetivo principal desta obra é servir como fonte de estudo e consulta, tanto para os estudantes no âmbito das áreas de alimentos, como para profissionais da saúde, com enfoque mais didático, científico e atual. Poderá ser utilizado em diversos estabelecimentos que envolvam manipulação de alimentos: restaurantes, lanchonetes, hospitais, hotéis, escolas, creches, aeroportos até mesmo ambientes domiciliar. Os profissionais convidados para escreverem os doze capítulos foram escolhidos por seus relevantes trabalhos em suas respectivas especialidades na área de Segurança Alimentar e Nutricional, encontrando-se aptos a abordar com profundidade os temas discorridos. Dessa forma, os temas abordados serão de grande valia para os leitores que buscam garantir a qualidade dos seus serviços visando a saúde, através de alguns aspectos como ingestão, absorção, excreção adequados de todos os alimentos a serem consumidos.
JOB SATISFACTION IN MATURE AGE COACHES EMPLOYED BY SPORTS SCHOOLS OF THE NORTHERN REGION
Authors:   Surgut State University, Surgut, Russia, Khokhlova N. I. , Panova E. O. ,   Ulyanovsk State University of Education, Ulyanovsk, Russia
Published: April 2023

The presented research is devoted to the study of the specifics of job satisfaction in coaches of sports schools in the northern region. Job satisfaction is associated with motivation and is a kind of an indicator of a sports organization performance. The purpose of the article was to identify the specifics of the components of job satisfaction in coaches of the northern region. Based on the comparative analysis of the components of job satisfaction in coaches of the Tyumen and Moscow regions, the authors stated the prospects for psychological support of sports schools coaches in the region under study. The article is intended for sports psychologists and leaders of sports organizations.
Description of self care management in hypertension patients
Authors: Barus Mardiati , Novitarum Lilis , Sitinjak Benedikta Sitinjak
Published: April 2023

Hypertension or high blood pressure is often referred to as the silent killer because the patient does not know that he or she has hypertension. Hypertension is also known as heterogeneous group disease because it can affect anyone and various age, social, and economic groups. Hypertension is also the third biggest risk factor that causes premature death because it can trigger congestive heart failure and cerebrovascular disease. Self care management is an activity carried out by patients with the intention of improving one's well-being, because of their awareness of the time frame for maintaining life, continuing personal development and living a healthy functional life. The purpose of this study was to identify self care management in hypertensive patients at Santa Elisabeth Hospital Medan. This type of research is a descriptive research design with a cross sectional approach. Sampling in this study used a total sampling technique, the number of samples was 136 people. The results showed that self-care management in hypertensive patients was based on self-integrity with a sufficient category of 90 people (72.7%), self-care management in hypertensive patients based on self-regulation with a sufficient category of 66 people (48.5%), self-care management in hypertension patients based on interaction with other health workers with sufficient category as many as 77 people (56.6%), self care management in patients with hypertension based on monitoring other health workers sufficient category as many as 74 people (54.4%), self care management in hypertension patients based on compliance with the recommended rules category enough for 66 people (48.5%). It is hoped that health workers will improve the provision of health education for hypertensive patients, provide information to improve the quality of life of hypertensive patients by doing good self care management.
The Effects of Preprocessing on Turkish and English News Data
Authors: PARLAK Bekir
Published: April 2023

In a standard text classification (TC) study, preprocessing is one of the key components to improve performance. This study aims to look at how preprocessing effects TC according to news text, text language, and feature selection. All potential combinations of commonly used preprocessing techniques are compared on one domain, namely news data, and in two different news datasets for this aim. Preprocessing technique contributions to classification performance at multiple feature sizes, possible interconnections among these techniques, and technique dependency on corresponding languages are all evaluated in this way. Using best combinations of preprocessing techniques rather than using or not using them all, experimental studies on public datasets reveals that, choosing best combinations of preprocessing techniques can improve classification accuracy significantly.
First-year Informatics Student Experiences of Emergency Online Teaching
Authors: McNeill Fiona , Robertson Judy , Abaci Serdar
Published: April 2023

Background and Context: The COVID pandemic had an unprecedented impact on Higher Education and potentially first-year students experienced a dramatic change to their expectations for university education as many had to start their studies in hybrid or completely online settings. In computer science programmes, female students may also have different — usually more negative — experiences than their male counterparts. Objective: The aim of this study was to understand the learning experiences of first-year Informatics students during this period with a focus on self-efficacy and satisfaction with online learning, attitudes to computer science, and gender differences (if any). Method: In a mixed-method study, 61 first-year undergraduate students completed an online questionnaire and 21 of them also took part in follow-up interviews. Findings: Whilst many students felt they were able to learn effectively online, social interactions with both peers and instructors were impacted and there were issues with a sense of belonging and confidence for many students, especially female students. In addition, female students consistently reported less confidence in their computer science abilities and their capacity to complete learning tasks online. Implications: Suggestions for teaching under these conditions include ensuring multiple communication methods between staff and students, as well as supporting student-student communication channels. In addition, teaching this cohort in future years will need further consideration as students may lack experience in interacting with staff and other students (social cohesion as a cohort).
O Lazer na Educação
Authors: Silva Denise de Castro Insaurriaga , Silva Igor de Oliveira Insaurriaga , Longo Kelly Regina
Published: April 2023

O presente estudo tem por objetivo principal identificar através de revisão integrativa de literatura as produções acerca do lazer no contexto educacional, publicados nos periódicos da Revista do Programa de Pós-Graduação Interdisciplinar em Estudos do Lazer (Licere) e da Revista Brasileira de Estudos do Lazer (RBEL). Delimitamos neste documento o lazer como atividade descontraída, realizada de forma desinteressada e principalmente prazerosa. Foram inicialmente encontrados 55 documentos que abordavam a temática, destes foram analisados qualitativamente 09 artigos. Concluímos que na última década há uma crescente no número de estudos que relacionam a educação com o lazer e que quase a metade dos artigos selecionados para avaliação foram escritos nos últimos quatro anos, porém ainda se faz necessário mais estudos, principalmente de forma intervencionista, a fim de aumentar as obras científicas que abordem a temática analisada.
Diagnóstico da Gestão, Estrutura, Organização e Oferta de Atividades de Esporte e Lazer no Estado de Rondônia
Authors: Cárdenas Ramón Núñez , Freire Ivete Aquino , Pumariega Yesica Núñez , Torres Catalina Dominga Pumariega
Published: April 2023

O trabalho apresenta um diagnóstico relativo à gestão, estrutura, organização de esporte e lazer no estado de Rondônia. Realizou-se uma pesquisa exploratória descritiva, com a utilização de métodos qualitativos, junto a gestores de esporte e lazer dos municípios do estado de Rondônia. A amostra foi selecionada por conveniência. Para a coleta de dados utilizou-se um questionário semiestruturado contendo 14 questões que tinham como objetivo identificar o perfil sociodemográfico dos gestores de esporte e lazer e as ações sociais de esporte e lazer da localidade. A pesquisa mostrou que a maioria tem formação em ensino superior, com predominância no curso de Educação Física; são homens, com média de idade de 47 anos. A experiência em gestão ficou entre 1 e 2 anos de prática. Os principais critérios assinalados para o uso dos espaços de esporte e lazer foram “Agendamento” prévio e “Gestão Compartilhada”.
Lazeres Marginais e Contemporaneidade
Authors: Castilho César Teixeira
Published: April 2023

O objetivo desse estudo porta sobre um relato de experiência vivenciado no transcorrer de uma disciplina optativa intitulada “Lazeres Marginais e Contemporaneidade” estruturada no âmbito de um Programa de Pós-graduação Stricto-Sensu. Visando ampliar as discussões das práticas de lazeres etiquetadas socialmente como “marginais”, preconizou-se articulações teóricas com autores(as) ainda pouco explorados(as) no campo específico dos Estudos do Lazer de sorte que novas perspectivas analíticas, sobretudo menos dicotômicas, sejam empreendidas empiricamente. Para além dos novos diálogos conceituais, observou-se igualmente avanços didáticos no manejo quanto ao engajamento da turma, bem como críticas e sugestões no que tange à operação de novos métodos de pesquisa. Em suma, trata-se de uma experiência valiosa sob à égide dialógica empregada e à troca amistosa oriunda do processo de ensino-aprendizagem.