bluuebunny/crossref_metadata_2025 huggingface dataset:
A microarray-komparatív genomhibridizálás (arrayCGH) praenatalis alkalmazása. Javaslat a hazai bevezetésre
Authors: Tidrenczel Zsolt , P. Tardy Erika , Pikó Henriett , Sarkadi Edina , Böjtös Ildikó , Demeter János , Kósa P. János , Beke Artúr
Published: March 2019

Abstract:

Invasive prenatal testing and conventional G-banding chromosome analysis have been considered to be the gold standard of fetal cytogenetic diagnosis. Standard karyotyping is, however, constrained by the limits of the resolution of using a microscope. The advantage of molecular karyotyping, array based methods is the evaluation of sub-microscopic copy number changes across the whole genome in a single analysis. The application of array comparative genome hybridization has greatly increased the detection of pathogenic chromosomal abnormalities in prenatal settings. Based on available data in the international literature of the last decade, the clinical utility of arrayCGH is the recognition of some 1–2% and 5–7% additional genetical information compared to metaphase karyotype alone in fetuses without ultrasound anomaly and in fetuses with ultrasonographically detected malformations, respectively. Thus arrayCGH improves the prenatal diagnosis of genetic abnormalities mainly in fetuses with structural sonographic findings. In the present paper we review the literature of chromosomal microarray and make a proposal for the application of the method in Hungarian prenatal genetical practice. Orv Hetil. 2019; 160(13): 484–493.
Simultaneous confidence intervals for all differences of coefficients of variation of log-normal distributions
Authors: NİWİTPONG Sa-aat , NİWİTPONG Suparat , THANGJAİ Warisa
Published: March 2019

A novel approaches were proposed for constructing simultaneous confidence
intervals for all differences of coefficients of variation of lognormal
distributions, using the method of variance estimates recovery
(MOVER) approach and the computational approach. There are then
compared with the fiducial generalized confidence interval (FGCI) approach
which presented by Thangjai et al. [1]. A Monte Carlo simulation
was conducted to compare the performances of these simultaneous
confidence intervals based on the coverage probability and average
length. Simulation results show that the MOVER approach is
satisfactory performances for all sample case (k) and sample size (n).
Moreover, the computational approach performs as well as the MOVER
approach when the sample size is large. Our approaches are applied to
an analysis of a real data set from rainfall in regions of Thailand.
Personalizing Precision Oncology Clinical Trials in Latin America: An Expert Panel on Challenges and Opportunities
Authors: Arai Roberto Jun , Guindalini Rodrigo Santa Cruz , Llera Andrea Sabina , O'Connor Juan Manoel , Muller Bettina , Lema Mauricio , Freitas Helano C. , Soria Tannia , Delgado Lucía , Landaverde Denis , Montenegro Paola , Riechelmann Rachel P.
Published: March 2019

The participation of patients in precision oncology trials needs to fulfill molecular-based selection criteria. This strongly limits accrual, and as a consequence, screening successes have decreased, costs have increased, and fewer subjects are enrolled. To achieve narrowed targets, studies have been forced to be multicenter and multinational to reach a larger pool of candidates. However, this globalization faces many challenges, as, for example, in the case of precision oncology trials. These trials have a complex structure that is dependent upon a high-tech infrastructure and knowledge in a dynamic environment. Given the movement of precision clinical cancer research to regions other than Europe and the U.S., it is important to evaluate the feasibility of performing such trials in lower-middle- and low-income countries. Here we critically discuss the advantages of conducting precision oncology clinical trials in Latin America and make suggestions on how to overcome the main challenges involved.
Myocarditis Surveillance in Patients with Advanced Melanoma on Combination Immune Checkpoint Inhibitor Therapy: The Memorial Sloan Kettering Cancer Center Experience
Authors: Lee Chuy Katherine , Oikonomou Evangelos K. , Postow Michael A. , Callahan Margaret K. , Chapman Paul B. , Shoushtari Alexander N. , Neilan Tomas G. , Fradley Michael G. , Ramanathan Lakshmi V. , Wolchok Jedd D. , Steingart Richard M. , Gupta Dipti
Published: March 2019

This letter to the editor describes myocarditis screening among patients undergoing combination immune checkpoint inhibitor therapy, in light of the consensus document from the Checkpoint Inhibitor Safety Working Group.
Seismic behaviour and strength prediction of corroded RC columns subjected to cyclic loading
Authors: Chang Zhao Qun , Xing Guo Hua , Luo Da Ming , Liu Bo Quan
Published: March 2019

In this paper, the performance degradation of reinforced-concrete (RC) columns with corroded longitudinal steel bars was experimentally investigated. Ten large-scale RC column specimens were constructed, and the longitudinal steel bars were corroded, to simulate the real severe environmental condition that concrete structures may encounter during their long-term service life, using a hybrid method. All specimens were tested under lateral cyclic loadings up to failure with the aim of revealing the effects of rebar corrosion level and axial compression ratio on the seismic behaviour of corroded RC columns. Test results indicate that an increase in the rebar corrosion level and axial compression ratio causes a marked degradation in the seismic performance of corroded RC columns, especially a reduction in the strength, ductility and energy dissipation capacity. To study the effect of the rebar corrosion level, the seismic damage indices of the corroded RC columns were also assessed using the damage model proposed by Park–Ang. In addition, a strength prediction method for corroded RC columns was proposed based on the modified compression field theory coupled with the conventional sectional analysis method. The proposed prediction method was then verified with the experimental results.
Polymerase Chain Reaction v1
Authors: LSR Rocha Lis
Published: March 2019

This was the PCR protocol used for each set of primers in the study Comparative genomics of Staphylococcus aureus associated with subclinical and clinical bovine mastitis (Rocha et al., 2019)
Polymerase Chain Reaction - Comparative genomics of Staphylococcus aureus associated with subclinical and clinical bovine mastitis (Rocha et al., 2019) v2
Authors: LSR Rocha Lis
Published: March 2019

Comparative genomics of Staphylococcus aureus associated with subclinical and clinical bovine mastitis (Rocha et al., 2019) Many efforts have been made to understand the pathogenesis of bovine mastitis to reduce losses and promote animal welfare. Staphylococcus aureus may cause bovine clinical mastitis, but it is mainly associated with subclinical infection, which is usually persistent and can easily reoccur. Here, we conducted a comparative genomic analysis between four strains of S. aureus causing subclinical infection (Sau170, 302, 1269, 1364), previously sequenced by our group, and two well-characterized strains causing clinical mastitis (N305 and RF122) to find differences that could be linked to mastitis outcome. A total of 146 virulence-associated genes were compared and no appreciable differences were found between the bacteria. However, several nonsynonymous single nucleotide polymorphisms (SNPs) were identified in genes present in the subclinical strains when compared to RF122, especially in genes encoding host immune evasion and surface proteins. The comparison of orthologous genes using OrthoMCL identified a membrane transporter in the genomes of the bacteria belonging to the subclinical group, but this finding was not confirmed by polymerase chain reaction (PCR) on a collection of field isolates of S. aureus associated with clinical or subclinical mastits. The secreted and surface proteins predicted by different in silico tools were compared through multidimensional scaling analysis, revealing a high degree of similarity among the six strains. However, differences were seen in the nucleotide sequences of a gene that codes for a hypothetical protein (cl3309) and a lipoprotein (cl3700). These findings were also analyzed by PCR on DNA extracted from field isolates of S. aureus. The lipoprotein, but not the hypothetical protein, was able to separate the clinical isolates from the subclinical ones. These results show that sequence variation among bovine S. aureus, and not only the presence/absence of virulence factors, is an important aspect to consider when comparing isolates causing different mastitis outcomes
Serum levels of oxidative stress marker malondialdehyde in breast cancer patients in relation to pathohistological factors, estrogen receptors, menopausal status, and age
Authors: Gubaljevic Jasmina , Srabović Nahida , Jevrić-Čaušević Adlija , Softić Adaleta , Rifatbegović Adi , Mujanović-Mustedanagić Jasminka , Dautović Esmeralda , Smajlović Aida , Mujagić Zlata
Published: March 2019

Introduction: The aim of this study was to determine the serum levels of malondialdehyde (MDA) in patients with invasive breast cancer in relation to its serum levels in patients with benign breast disease, and to investigate correlation between MDA serum levels with pathohistological prognostic factors (tumor size, lymph node involvement, and histologic grade [HG]), estrogen receptor (ER) status, and with breast cancer patient’s age and menopausal status.

Methods: A total of 43 with well-documented invasive breast cancer were included in this study: 27 with positive axillary’s lymph nodes, and 16 with negative axillary’s lymph nodes, and 39 patients with findings of benign breast diseases. MDA determination in serum of breast cancer and benign breast disease patients was performed by the fluorimetric method, immunohistochemical staining was performed for ER, and routine pathohistological examination was conducted for pathohistological factors.

Results: MDA serum levels in breast cancer patients were significantly higher than MDA serum levels in benign breast disease patients (p = 0.042). No statistically significant difference between MDA serum levels in breast cancer patients with and without lymph node metastases was found (p = 0.238). No statistically significant correlations between MDA serum levels and tumor size (p = 0.256), HG (p = 0.124), or number of positive lymph nodes (0.113) were found. A statistically significant correlation between serum MDA levels and ages of breast cancer patients with lymph node metastases was found (p = 0.006).

Conclusion: Obtained results support the importance of MDA in the carcinogenesis of breast cancer. According to our findings, serum level of MDA could not be a useful prognostic factor in breast cancer.
ABOUT THE COMPLETION OF SCIENTIFIC AND TECHNICAL DEVELOPMENTS OF THE SITE OF THE HISTORY OF PHILOSOPHY DEPARTMENT OF THE FACULTY OF PHILOSOPHY
Authors: Kononenko T.
Published: March 2019

The purpose of the article is to inform that in the department of the history of philosophy of the Faculty of Philosophy of the Taras Shevchenko National University of Kiev, the team of the department has completed the development of a scientific and educational site in the framework of scientific research work. Function of the site of the Department of History of Philosophy under the title "Taras Shevchenko National University of Kiev. Department of the History of Philosophy" is the promulgation of the intellectual result of scientific and educational activities of the collective in the field of philosophical and humanitarian knowledge.
POLITICAL PHILOSOPHY OF WILLIAM OF OCKHAM
Authors: Trush T.
Published: March 2019

The purpose article will deal with the works by William of Ockham, an English scholastic philosopher Franciscan. Interconnection of the thinker's philosophical views with his political judgments is highlighted. The tasks and duties of the Church and the state are defined. The results of this study have been developed and introduced into the educational process of the Taras Shevchenko National University of Kyiv. This is a discipline "History of Philosophy" in "Political Science". The results of the article give an opportunity to broaden and deepen theoretical knowledge of students in the field of historical and philosophical science of the Middle Ages. This article deals directly with William of Ockham's political thought. The influence of Ockham's philosophical opinions on political views is also shown. The political illness of papacy plenitude potestatis and the possibilities of solving it is clarified. As Okkama's authorial position in solving political issues is far from perfect, the article shows the progress in solving Marsilius of Padua's political issues. The obtained results allow stating that such studies give a possibility to deepen the theoretical knowledge of the students "political science" and "public service" at the Taras Shevchenko National University of Kyiv.
BİNA ORTAMLARININ ÇALIŞAN REFAHI VE PERFORMANSI ÜZERİNE ETKİSİ
Authors: Özkan Gülay , Gürbüz İ Bülent
Published: March 2019

İnsanlar günlerinin büyük bir bölümünü binalarda
geçirmektedirler. Gelişmiş endüstriyel toplumlarda tüm yarı zamanlı, esnek
zamanlı, uzaktan çalışma seçeneklerine rağmen insanların hala büyük bir
çoğunluğu ofis binalarında çalışmaktadırlar. Binaların tasarımı, inşası, bakımı,
mimarlık, inşaat mühendisliği, tesis yönetimi gibi ayrı ayrı disiplinlerin
çalışma alanı olmuştur. Çalışanların üretkenliği iş memnuniyeti, sağlık ve
refahı ile ilgili araştırmalarda çoğunlukla örgütsel davranış disiplini
içerisinde ele alınmaktadır. Ancak kuzey Amerika’da ve Avrupa’da uzun yıllardır
yoğunlukla incelenen ve sözü edilen disiplinleri bir araya getiren çalışmalara
Türkiye’de henüz rastlanmamaktadır. Bu çalışmanın amacı kavramsal bir çerçeve içerisinde,
fiziksel çalışma ortamlarının kalitesinin kullanıcılarının refahı, sağlığı ve
üretkenliği üzerindeki etkilerini mevcut literatüre dayanarak bilgilendirmektir.
Çalışma ortamlarını etkileyen çevresel faktörlerin çalışanların kişisel ve çalışma hayatlarındaki önemini
vurgulanarak, bina tasarımlarının bu ihtiyaca hizmet etmesi, yatırımcıların
gerekli yatırımları yaptıkları takdirde bu yatırımların karşılıklarını
alabilecekleri vurgulanmaktadır.
Does the Short Period of Resistance Training May Improve the Sleep Quality? Pilot Study
Authors: Polito Luis Felipe Tubagi , Marin Douglas Popp , Montenegro Carla Giuliano Pinto de Sá , Zanetti Marcelo Callegari , Junior Marcelo Villas Boas , Dias Helton Magalhães , Rica Roberta Luksevicius , Mascarenhas Júlia , Junior Aylton Figueira , Brandão Maria Regina Ferreira
Published: March 2019

Purpose: The present study aimed evaluated the influence of exercise program on sleep quality of sedentary individuals. Methods: The study evaluated 30 subjects after resistance training session constituted by six multi-joints exercises (leg press, chest press, machine let pull down, seated machine shoulder press, crunches and machine trunk extension) three times a week for 40 days. The intensity of the effort was controlled using the follow criteria: the ideal repetitions for each set was between eight and fifteen. The Pittsburgh Sleep Quality Questionnaire (PSQI) was applied before and after training period. Results: There was a significant effect of short-term resistance training on all sub-scores of PSQI (p0.05). Conclusion: The resistance training program was able to improve the sleep quality in healthy subjects. In addition, the applicability of low-cost instruments (psychometric instruments like PSQI) to evaluate health parameters, which could be strengthened by other studies.
Как и зачем измерять и сравнивать государственную состоятельность разных стран мира? Теоретико-методологические основания
Authors: Ахременко Андрей , Горельский Илья , Мельвиль Андрей
Published: March 2019

В данной статье рассматриваются теоретико-методологические основания концепта государственной состоятельности, под которой понимается способность государства выбирать и эффективно реализовывать собственные решения, в том числе касающиеся внутренней и внешней политики. Авторы подчеркивают, что одной из отличительных особенностей концепта является его многомерность, что приводит их к идее рассмотрения государственной состоятельности как многосоставного явления, комплекса взаимосвязанных способностей (“состоятельностей”), которыми обладает современное государство. В соответствии с данным предположением авторы останавливаются на трех основных измерениях государственной состоятельности: военно-принуждающей (обеспечение внешней безопасности и внутреннего порядка), экстрактивной (доступные в распоряжении государства финансовые ресурсы) и административно-бюрократической (качество административных и бюрократических институтов) способностях государства. Выбор измерений опирался прежде всего на идею наличия у любого современного государства ключевых (“зонтичных”) функций, которые, в свою очередь, могут послужить критерием для проведения сравнительных исследований. При переходе к операционализации подчеркивается особая важность соблюдения баланса между “максималистским” и “минималистским” подходами к отбору показателей. В рамках работы приводится обоснование использования набора индикаторов государственной состоятельности (для принуждающей способности – данные по военным расходам и агрегированный показатель контроля над насилием; для экстрактивной способности – собираемость подоходных налогов и совокупные доходы государственного бюджета, оба – в процентах к ВВП; для административно-бюрократической способности – агрегированный показатель качества управленческих институтов и уровень теневой экономики), который послужит основой для проведения эмпирического исследования и выделения характерных для отдельных групп стран устойчивых структур государственной состоятельности.
Революционные волны второй половины ХХ в.: взаимосвязь геополитики, насилия и легитимности
Authors: Розов Николай , Пустовойт Юрий , Филиппов Сергей , Цыганков Владислав
Published: March 2019

Революционные волны, формирующиеся следующими друг за другом взаимосвязанными революциями, представляют собой макрополитические целостности, динамика которых, с одной стороны, интегрирована в региональные и мировые процессы, а с другой стороны, имеет собственные закономерности. В статье представлены понятийный каркас подхода, основные гипотезы о динамике революционных волн, а также причины и основные характеристики нескольких волн второй половины XX в.: в Африке, в Карибском заливе и в Юго-Восточной Азии в 1950-1960-е годы и в Центральной Европе в конце 1980-х годов. Проанализировано влияние на эти волны геополитических напряжений и идеологических веяний, а также воздействие самих этих волн на геополитику, геоэкономику, геокультуру на соответствующем континенте или даже в мире в целом. Отдельные революции в каждой волне и сами волны характеризуются различными уровнями насилия; революции могут быть отягощены гражданскими и международными войнами. Процессы признания послереволюционных режимов – как противостоящими коалициями держав, так и глобальными международными организациями – проходят по-разному и порой весьма драматически, что всегда связано с позиционированием этих режимов в идеологической, политической и военно-стратегической сферах, а также с масштабом жертв, признанием (не)оправданности допущенного насилия. Геополитика, насилие и легитимность революционных волн составляют единый комплекс со сложной динамикой, общие черты и особенности которой проанализированы на примере нескольких волн второй половины XX века.
К дебатам о теории международных отношений: переосмысление междисциплинарности
Authors: Павлова Елена , Романова Татьяна
Published: March 2019

Публикация представляет собой отклик на ряд статей, посвященных дискуссии о современном состоянии науки о международных отношениях, начатой в предыдущих выпусках журнала “Полис. Политические исследования”. Акцент сделан на проблемах изучения теории международных отношений в Российской Федерации. Подчеркивается недостаточное в отечественных исследованиях внимание к современным тенденциям, а также проблема восприятия теоретических подходов и методов через призму идеологии, что в итоге ведет к сложностям включения российского академического сообщества в мировую научную дискуссию. Особое внимание уделено специфике формирования новых теоретических подходов, где тон задает междисциплинарность. Этот аспект становится центральной темой дебатов о самой сути теории международных отношений, а следовательно, его игнорирование серьезно ограничивает возможности отечественной аналитики. В качестве иллюстрации приведен пример анализа Глобальной стратегии Европейского союза 2016 г., ключевой категорией которой стало понятие “стрессоустойчивость”. В статье демонстрируется неизбежность обращения к теоретическим наработкам для анализа как этого документа, так и современных отношений России и Европейского союза в целом. В первом разделе авторы фокусируются на специфике обращения к теории международных отношений российским академическим сообществом. Второй раздел посвящен основным проблемам современной дискуссии о сути международных отношений. В третьем разделе приводится пример применения теоретических подходов к конкретному документу, значимому для отношений России и Европейского союза (Глобальной стратегии Европейского союза 2016 г.).
Образы России: размышляя об эпохах перемен
Authors: Зарубина Наталья , Носкова Антонина
Published: March 2019

Статья посвящена рефлексии эмпирических данных многолетних мониторинговых исследований, представленных в коллективной монографии ученых Института социологии РАН “Двадцать пять лет социальных трансформаций в оценках и суждениях россиян: опыт социологического анализа”. В качестве несомненного достоинства монографии отмечается богатство и многообразие данных, представляющих сложный, порой противоречивый образ России, прошедшей через эпохи радикальных трансформаций. Материалы позволили авторам выдвинуть предположение о дихотомии коллективной памяти россиян: изменчивости, непостоянстве исторической памяти – когнитивно-эмоционального восприятия исторических событий, но вместе с тем и относительной устойчивости социальной памяти как средстве воспроизводства социокультурной традиции в массовом сознании народа. Историческая память в трансформирующихся обществах выступает и основой солидарности, и фактором возникновения расколов и конфликтов на почве противоречий в понимании значимых событий прошлого. Авторы констатируют неопределенность, размытость коммуникативной, семейной и коллективной памяти о влиянии Октябрьской революции 1917 г. на судьбы отдельных семей и общества. Причины этого – недостаточность коммуникации между поколениями, отсутствие интереса к прошлому и выраженной идеологической оценки результатов революции. Позитивное отношение к советскому периоду сопровождается негативным отношением к революции как форме общественного развития, ей предпочитают некатастрофические формы развития, даже если фактически они оборачиваются “застоем”. Устойчиво наблюдаемая в опросах россиян тенденция позитивного оценивать советский период интерпретируется авторами как проявление устойчивости социальной памяти. Исторический выбор между моделями централизованного общинного и либерального государства обусловлен стабильными представлениями о необходимости контроля государства над основными отраслями экономики и приоритете прав и интересов государства перед индивидуальными правами и интересами. Однако ни историческая, ни социальная память россиян не являются целостностью солидарно разделяемых идеалов, ценностных образцов и моделей оптимального государственного устройства. Впрочем, отсутствие у народа единого представления об идеале общественного устройства можно рассматривать как защиту от потенциальных революций и условие для созидательного поиска и строительства будущего страны через диалог гражданского общества с политической властью.
RESPONSE SURFACE BASED OPTIMIZATION OF RIBBED ISOSCELES TRIANGULAR TWISTED TAPE HEAT EXCHANGER USING ENTROPY AUGMENTATION GENERATION NUMBER WITH AL2O3 NANO WORKING FLUID
Authors: KUMAR Pavan
Published: March 2019

In this work, a combination of passive techniques like providing ribs on the duct surface, inserting twisted tapes were employed at different configurations and analysed using ANSYS Fluent 17.2. The enhancement is probed by placing ribs on the duct surfaces at various angles. Twisted tape inserts were used in conjunction with ribs on the duct and an output parameter, Entropy Augmentation Generation Number (EAGN) is analysed when having an Al2O3 nanofluid (ϕ=3%) as working medium. In furtherance, tapes of isosceles triangular projections with variable configuration, such as rib angles (300<α< 900), Internal angle (300<β<900) and projection distance (1mm< x< 5mm) were also inserted in place of plain twisted tape inserts to verify the enhancement promised by this alteration. As expected, rate of heat transfer due to the presence of isosceles triangle projections gave decent augmentation. Later Response Surface based optimization was employed with non-parametric regression and genetic algorithm to make an investigative search of all the modified parameters so as to suggest best blend of inputs for low Entropy Augmentation Generation Number. Optimum performance was obtained at rib angle of 300, projection distance of 2.1mm and Internal angle of 44.40 with entropy augmentation number value of 0.77. The performance of Genetic Algorithm was compared with Micro Genetic Algorithm; it shows that optimized result is obtained less than half the time using Micro Genetic Algorithm.
A study of clinico-microbiological profile of surgical site infections in a tertiary care hospital
Authors: Kochhal Niharika , Mudey Gargi Dangre , Choudhari Sonali Zadbuke
Published: March 2019

Background: Surgical Site Infection (SSI) is the 3rd most commonly reported infection accounting for 14-16% of all Health care associated infections among hospitalized patients. Surgical Site Infections are responsible for an increased economic burden to healthcare systems, including additional postoperative hospital stay and costs. The present study was conducted in a tertiary care hospital to study the incidence, risk factors and associated pathogens of Surgical Site Infection.Methods: A total of 100 patients operated of clean and clean-contaminated surgeries from Orthopaedics, Surgery and Obstetrics and Gynaecology Department of AVBRH, Sawangi were included.Results: Overall infection rate was 6%. Patients in the age of above 71 years showed maximum rate of infection (14.28%) followed by 61 to 70 years (10%) and 51-60 years (10%). Surgical site infection rate was 4.65% (2/43) in clean operative wounds and 7.02% (4/57) in clean contaminated operative wounds. Escherichia coli and Klebsiella pneumonia were the most common organisms causing SSI. None of the risk factor was found significantly associated with the development of SSI.Conclusions: This study gave a better understanding of microbial pathogens of our institute which may have epidemiological and therapeutic implications. It will act as a pilot study to conduct further such larger research.
A cross sectional study of clinical profile and evaluation of pulmonary hypertension in Chronic Obstructive Pulmonary Disease patients in a tertiary care hospital of Mangalore, India
Authors: Ramesh Kshama S. , Rai Devdas B. , Abdulla Shayma Sheikh , K. Jyothsna B.
Published: March 2019

Background: The objectives was to study the clinical profile of COPD patients and to evaluate pulmonary hypertension in COPD patients by non-invasive methods.Methods: A prospective observational study of patients who satisfy all inclusion and exclusion criteria in OPD or admitted in medical wards of AJIMS Mangalore. The study was conducted from October 2017 to October 2018 with the sample size of 90 subjectsResults: Out of 90 subjects 53 (58.8%) of them had pulmonary hypertension. Among the subjects who had pulmonary hypertension 29 (54.72%) of them had moderate pulmonary hypertension, 17 (32.08%) of them had severe pulmonary hypertension and 7 (13.20%) of them had mild pulmonary hypertension. Mean age among the subjects who had pulmonary hypertension was 64.24+7.62yrs and mean age among the subjects who didn’t had pulmonary hypertension was 51.87+8.97yrs. There was a statistically significant difference found between mean age and pulmonary hypertension. Mean duration of diseases among the subjects who had pulmonary hypertension was 8.13+1.74yrs and Mean duration of diseases among the subjects who didn’t had pulmonary hypertension was 5.36+1.98yrs. There was a statistically significant difference found between mean duration of disease and pulmonary hypertension.Conclusions: Due to high prevalence of pulmonary hypertension we suggest screening for the all COPD patients for cardiac complications. This will help in identifying the individual who requires close monitoring and also in reducing the mortality.
Role of high sensitivity C- reactive protein as a marker of inflammation and its prognostic significance in chronic kidney disease patients
Authors: Khunte Sanjeev Kumar , Kumar Jitendra , Khunte Prakash
Published: March 2019

Background: Chronic kidney disease (CKD) is a clinical syndrome due to irreversible renal dysfunction leading to excretory, metabolic and synthetic failure culminating into accumulation of non-protein nitrogenous substances and present with various clinical manifestations. Elevated circulating concentrations of CRP are a common phenomenon in ESRD patients. The prevalence and magnitude of inﬂammation increases as renal function declines.Methods: The current cross-sectional observation study was conducted in Rajendra institute of medical sciences, Ranchi during study period October 2015 to September 2017 on admitted patients with chronic kidney disease. 90 patients of different age groups between 16-75 years were enrolled in the study. Samples were selected by using simple random sampling method. Informed consent was obtained from all the patients.Results: 85.6% of the patients studied were males and 14.4% of the patients were females. Most cases of CKD were associated with hypertension (77.8%) out of which there were 62 males and 8 females, followed by DM (25.5%) where there were 20 males and 3 females. 44.4% cases had an elevated level of hs-CRP (more than 3 mg/L) while 55.6% patients had hs-CRP below 3 mg/l. Out of 40 high hs-CRP patients, 35 were male and 5 were female. Patients with elevated creatinine level had significant high hs-CRP level.Conclusions: Chronic kidney diseases, Cardiovascular disease, HS-CRP, Inflammation
Role of yoga in improving quality of life of hypothyroidism patients
Authors: Akhter Javed
Published: March 2019

Background: Yoga is science of simple living that enlightens all aspects of life physical, mental, psychic and spiritual. Yoga helps in balancing and harmonizing body mind and emotions. Yoga improves pulmonary ventilation and gas exchange. Thus, it improves respiratory health and general wellbeing of individual. Aim was to assess role of yoga in improving the quality of life of hypothyroidism patients before and after 6 months of yoga.Methods: Sixty adult patients of hypothyroidism participated in this prospective study and were divided into two groups. Quality of life of all the patients was assessed by WHO QOL BREF document in form of. The data obtained was analyzed using SPSS software (version 16.0). Four domain scores were assessed. Unpaired t test and paired t test was to compare normal controls with hypothyroid patients.Results: There was a significant improvement of 17.79% in the physical aspect of quality of life of patients in the yoga group at the end of six months as compared to the patients in the control group. Significant improvement of 18.38% was also observed in the psychological aspect of quality of life of patients in the yoga group at the end of six months as compared to control group.Conclusions: There is a profound improvement in physical and psychological domains of quality of life of hypothyroid patients. However, further studies over longer period of time may be helpful to evaluate the effect of yoga in these aspects of life.
A clinical epidemiological study of gallbladder carcinoma: a retrospective study
Authors: Sahai Shweta
Published: March 2019

Background: Incidence of gallbladder carcinoma (GBC) is high among the north Indian population. It may be due to environmental, dietary and reproductive factors. Evaluation of GBC epidemiology will provide important insights into determining causes and risk factors for gallbladder cancer. The aims and objectives were to study the epidemiology, clinical presentation and etiological factors of GBC.Methods: Fifty-one cases of GBC were studied retrospectively at Cancer Hospital and Research Institute (CHRI) Gwalior, Madhya Pradesh, India from January to December 1998. All the patients underwent a detailed history taking and physical examination followed by routine laboratory tests and other investigations including ultrasonographic and computed tomography scan of whole abdomen. Histopathological evaluation of gallbladder specimen was also performed after surgical resection of the GB mass.Results: Incidence of GBC at this centre was 1.49%. GBC was more prevalent among old women (mean age 52.62±12.14 years) belonging to low socio-economic status (SES) (52.94%). Most common presenting symptom of GBC was pain in right hypochondrium (70.4%) followed by anorexia (42.8%), pruritus (35.7%), weight loss (31.2), nausea and vomiting (30.4%). Histopathological examination revealed majority of the case to have adenocarcinoma (84.31%). Gallstones were present in 35.29% patients.Conclusions: GBC is more prevalent in older women belonging to low SES. Gallstones remain the chief risk factor for this malignancy. Histopathological examination of all cholecystectomy specimens for early pre cursor lesion could serve as an important means of early detection of this carcinoma.
Ultrasound evaluation of non-cystic renal masses and correlation with ultrasound guided fine needle aspiration cytology/biopsy
Authors: Chhadi Shyam , Chhadi Tulsi , Limbgaonkar Jalinder
Published: March 2019

Background: The purpose of present study was to identify sonologically, the cystic and non-cystic renal mass lesions, to attempt differentiating benign lesions from the malignant ones and to correlate ultrasound findings with ultra sonographically guided cytological or pathological findings.Methods: In this hospital based prospective observational study, all the patients with confirmed renal mass were subjected to USG guided fine needle aspiration cytology (FNAC). All the patients presenting with lump in abdomen, haematuria or pain in abdomen, wherein the clinical diagnosis of renal mass was being considered by the clinician, were enrolled for the study. Total 54 participants were enrolled. Those with confirmed renal mass were subjected to USG guided FNAC and which was carried out in supine position by transabdominal route in all patients.Results: About 42 participants were retained for final analysis; since FNAC was not possible in 12 patients. Pain in abdomen (36, 85.7%), mass in abdomen (34, 81%) were the most predominant clinical findings. Mixed echogenicity was the commonest echo pattern (42, 77.7%) on ultrasonography. Histopathologic/cytologic examination of the 39 malignant cases confirmed renal cell carcinoma (18, 46.5%) to be the commonest malignancy, followed by Wilms’ tumour (10, 26%). Out of the 39 cases in which clinico-radiological diagnoses were correlated with histo-cytological diagnoses, it was found to be consistent in 30 (77%) cases and inconsistent in 9 (23.1%) cases.Conclusions: Fine needle aspiration cytology/biopsy performed under ultrasonography guidance demonstrates high diagnostic accuracy. It is hence recommended as part of fundamental approach to the diagnosis of non-cystic renal mass.
Accuracy of imaging findings compared with that of histopathological findings of the ovarian lesions
Authors: Kumar Ponnam Bharath , Reddy Prem Sai
Published: March 2019

Background: Newer imaging techniques have emerged, and it is necessary to study their accuracy in comparison to the gold standard of histopathology for increasing accuracy of diagnosis. Ovarian tumors are difficult to diagnose when they are of small size. But their diagnosis should be done at an earlier stage for effective outcome of the management of these tumors. The objective was to study accuracy of imaging findings compared with that of histopathological findings of the ovarian lesions.Methods: This study was done for a period of two years from December 2010 to May 2012. A total of 30 patients who were clinically suspected to have ovarian pathology were referred to us for ultrasonography. In 30 patients, who were referred for sonography a total of 36 ovarian masses was found? Each patient was examined by Trans abdominal sonography / Trans vaginal sonography, MRI (Pre and Post contrast) and CT when required.Results: Sonography could detect the origin of mass accurately in 29 (80.5 %) masses and MRI could detect the origin accurately in 34 (94.4%) masses. Sonography characterized 33/36 (91.6%) masses correctly. MRI correctly characterized 34/36 (94.5%) cases and tissue content was identified correctly. The sensitivity of imaging findings for correctly identifying malignant lesions was 100% and sensitivity for correctly making a benign diagnosis was 92.5%. The specificity of imaging findings for correctly identifying malignant lesion was 92% and specificity for correctly making a benign diagnosis was 84.6 %.Conclusions: MRI is significantly superior to US in all respects due to the excellent soft tissue contrast and organ-specific information generated in the pelvis.
A study of hepatobiliary manifestations in dengue viral infection
Authors: N. Venkata Rajaih , Thirunadhar R. , Dasari Nikitha
Published: March 2019

Background: Dengue viral infection is a major and important public health problem in many South East Asian (SEA) countries and also in more than 100 countries of tropical and subtropical region. The aim of study was to assess the frequency and degree of hepatobiliary dysfunction in adults with dengue infection presenting to our tertiary hospital, Karimnagar.Methods: The study was a prospective observational study conducted on 120 adult patients of serological proven dengue infection with hepatic and biliary manifestations, admitted during the period of from June 2016 to June 2017. Investigations included complete blood count, liver function test, viral serology, sepsis screen, ultrasound abdomen.Results: Majority of cases in age group of 20-56 years with male: female ration of 1.7:1. Of all the cases, 53% patients were categorized into dengue fever group, 25% into dengue hemorrhagic fever group, and 27.7% into dengue shock syndrome group in accordance to WHO guidelines.Conclusions: This study was showed that a significant hepatobiliary derangement is seen in severe cases of dengue. Early recognition of such perturbations helps guide further management to prevent mortality.
Cardio vascular risk profile among diabetic patients attending a tertiary care hospital in Odisha, India
Authors: Patro Shubhransu , Kande Sushant , Deo Dandi Suryanarayana , Pathi Debasis , Arora Sidharth , Acharya Swastik
Published: March 2019

Background: Diabetes is associated with reduced quality of life and wide range of complications including CVD which vary geographically. The likely causes for the dramatic increase in the CVD rates include lifestyle changes associated with urbanization and the epidemiologic as well as nutritional transitions that are associated with economic development. This study aims to identify the CVD risk factors that exists among the diabetes patients of Odisha.Methods: The study was conducted in KIMS during July-December 2016. A total of 300 diabetic and 300 non-diabetic patients were included in the study. Medical history and lifestyle data were collected using a pretested structured format and a separate checklist for laboratory results. Patient interview, physical examination and laboratory analysis were performed. Chi-square test was performed to identify significance of difference between prevalence of risk factors between diabetic and non-diabetic groups. Multiple logistic regression analyses (forward stepwise addition) were performed to identify the variables significantly associated with CVD risk factors. Significance level of 5% was considered.Results: Total 376 males and 224 females were enrolled in the study with higher proportion of male participants in both diabetic and non-diabetic groups. Overall mean age of study subjects was 47.5±10.4 years. No significant difference was observed for demographic distribution between both groups. Prevalence of dyslipidaemia among diabetic patients was 86%, while prevalence of hypertension and dyslipidaemia were 71% and 62.3% respectively.Conclusions: Overall prevalence of CVD risk factors observed in this study among population of Odisha, is higher compared to reported prevalence for other regions of India.
Populismo, Austeridade e Déficit Democrático
Authors: Muniz Veyzon Campos
Published: March 2019

O presente texto especial apresenta tradução de artigo de Andrew Watt e de Lászoló Andor, veiculado no portal britânico Social Europe, acerca do avanço político de tendências populistas no contexto de austeridade econômica e do respectivo impacto desse movimento no ambiente democrático europeu, a partir de cinco reflexões primordiais apresentadas em segmentos temáticos próprios. No desenvolvimento textual, utilizou-se do método interlingual de tradução.
O acesso à justiça e o mínimo existencial: a assessoria jurídica popular na promoção dos direitos fundamentais
Authors: De Freitas Janaina Helena
Published: March 2019

Resumo: O Brasil é uma país que, por ser periférico, possui muitos problemas que necessitam de ser resolvidos com enfoque jurídico. No presidente artigo, pretende-se realizar uma análise da a questão do acesso à justiça como componente da teoria do padrão do mínimo existencial, seguindo a vertente proposta por Ana Paula de Barcellos.  Dentro do acesso à justiça, será analisado o papel das assessorias jurídicas populares como instrumentos de promoção dos direitos fundamentais e do acesso à justiça.
Sobre a ampliação do âmbito de aplicação material da convenção de Viena acerca dos contratos de compra e venda internacional de mercadorias
Authors: Sáez Mauricio Inostroza
Published: March 2019

Os artigos 1.1, 2 e 3 da CISG dispõem que a referida Convenção rege os contratos de compra e venda. Apesar do seu escopo substantivo ser aparentemente estreito o texto busca demonstrar que ele foi ampliado de duas maneiras: em primeiro lugar, pela própria CISG, nos termos do artigo 3. Em segundo lugar, pela doutrina e pelo labor dos tribunais ao expandirem a esfera substantiva de aplicação da lei. a CISG, aplicando-a a contratos que não se enquadram no conceito de compra e venda.
¿Úteros para alquilar o la violación tecnológica de la mujer?
Authors: Monzón José María
Published: March 2019

¿Por qué importa la maternidad subrogada? Esta maternidad ha sido pensada como un medio para terminar con la infertilidad como estigma. Esta técnica médica involucra - principalmente - las vidas de mujeres que por su situación social o económica buscan obtener – al menos por un tiempo - un bienestar. Ellas son las que llevan los hijos de otras. Esto ayuda a que – especialmente - las personas ricas puedan ser padres sin los costos de una maternidad. Se favorece mercado en aumento de embriones en el cual clínicas y agencias buscan satisfacer los deseos de sus clientes de ser padres. Pero esta práctica puede ser vista también como una explotación de las mujeres al igual que como una práctica ilícita. Los Estados no se ponen de acuerdo en este tema, mientras los futuros padres persiguen los menores costos lo que no significa que logren mejores servicios. De este modo crece el turismo reproductivo en tanto que los Estados debaten sobre los argumentos para prohibirla o permitirla.
İmalat İşletmelerinde Enerji Verimliliğinin Yapısal Eşitlik Modeli İle İncelenmesi
Authors: ŞENOL Leyla , AKMAN Gülşen
Published: March 2019

Bu çalışmanın amacı, enerjinin verimli kullanılması ve tasarrufun
sağlanması konusunda katkı sağlamak ve farkındalık yaratmaktır. Bu amaçla
imalat işletmelerinden enerji verimliğini etkileyen etmenlerin etki
derecelerini ve aralarında ilişki olup olmadığının belirlenmesi için anket
yönetimi ile veri toplanmıştır. Faktör analizi sonucunda beş faktör
belirlenmiştir. Yapısal Eşitlik modeli analizine göre, otomasyon ve enerji
verimliliği arasında istatistiksel olarak anlamlı bir ilişki bulunmamıştır.
Ancak, enerji verimliliği ile eğitim, denetim ve yönetim arasında pozitif yönde
ve istatistiksel olarak anlamlı bir ilişki olduğu belirlenmiştir. Enerjinin
verimli kullanılması ve tasarrufun sağlanması için, çalışanlara eğitim
verilmesi, denetimin yapılması ve yönetim faktörünün önemi ortaya konmuştur. Bu
bağlamda Enerji verimliliği bilinci her düzeyde geliştirilmeli, var olan enerji
politikalarına ilave enerji tasarrufu politikaları oluşturulmalı ve denetim
mekanizması ile kontrol sağlanmalıdır.
OECD Ülkelerinde Gelir Dağılımının Belirleyenleri
Authors: ACUN Serdar
Published: March 2019

ABD
emlak piyasasında başlayan daha sonra Avrupa’ya borç krizi olarak sirayet eden
2008 küresel krizi, gelir dağılımına ilişkin tartışmaları yeniden
alevlendirmiştir. En üst %1’lik gelir grubuyla en alt %99’luk gelir grubu
arasındaki artan farklılığın nedenleri ve eşitsizliğin nasıl çözüleceğine
ilişkin konular tartışmaların genellikle merkezinde yer almıştır. Bu çalışmada
amaç OECD ülkelerinde gelir dağılımını etkileyen faktörleri ortaya koymaktır.
İlk başta OECD’de gelir dağılımını analiz eden çalışmalar ele alınmıştır. Daha
sonra ise OECD ülkelerinde gini katsayısı, işgücüne katılım oranı, reel emek
gelirlerindeki değişim, P80/P20 oranı gibi veriler yorumlanmıştır. Verilerin
yorumlanmasından sonra OECD ülkelerinde gelir dağılımının belirleyenleri
üzerine ekonometrik bir analiz uygulanmıştır. 
Analiz sonucunda   yaş bağımlılık
oranı, ekonomik küreselleşme ve finansallaşma gibi faktörlerin eşitsizliği
artırdığı, emek gelirlerinin milli gelir içindeki payı ve sivil haklardaki
artışın ise adaletli dağılıma olanak sağladığı sonuçlarına ulaşılmıştır.
Örgüt Kültürü ve Örgüt İkliminin Örgütsel Sessizlik Üzerindeki Etkisinin Analizi
Authors: YALÇINSOY Ayhan
Published: March 2019

Bu çalışmanın amacı, sağlık sektörü çalışanlarının örgüt kültürü ve örgüt iklimi algılarının örgütsel sessizlik algıları üzerinde etkisi olup olmadığını belirlemektir. Araştırmanın örneklemini Adana ilinde görev yapan sağlık sektörü çalışanı 411 personel oluşturmaktadır. Araştırmada elde edilen veriler, araştırmanın amacı doğrultusunda çeşitli istatistik metot ve test teknikleri (frekans dağılımı, t-testi, ANOVA, regresyon, korelasyon) kullanılarak PSPP 0.10.2 istatistik paket programı yardımıyla değerlendirilmiştir. Anlamlılık düzeyi 0.05 olarak kabul edilmiştir. Araştırmada çalışanların örgüt kültürü ve örgüt iklimi algıları ile örgütsel sessizlik algıları arasında pozitif yönlü ve zayıf bir ilişki olduğu sonucuna ulaşılmıştır. Ayrıca örgüt kültürünün örgütsel sessizlik üzerinde zayıf da olsa bir etkisinin olduğu tespit edilmiştir.
Beden Eğitimi Öğretmenliği Bölümlerinin Yeterliliği İle İlgili Öğretmen Görüşleri
Authors: UĞRAŞ Sinan , GÜLLÜ Mehmet
Published: March 2019

Bu araştırmanın amacı beden eğitimi ve spor öğretmenliği bölümlerinin yeterliliği hakkında öğretmen görüşlerini incelemektir. Araştırmada karma yöntemlerden yakınsayan paralel desen  kullanılmıştır. Nitel araştırma grubunu, 20 beden eğitimi öğretmeni oluştururken nicel araştırma grubunu 283 beden eğitimi öğretmeni oluşturmaktadır. Veri toplama aracı olarak, “yarı yapılandırılmış görüşme formu” ve “Beden Eğitimi ve Spor Öğretmenliği Bölümlerinin Yeterliliği Ölçeği (BESÖBYÖ)” kullanılmıştır. Araştırma sonucunda beden eğitimi öğretmenleri mezun oldukları lisans programlarının Milli Eğitim Bakanlığına bağlı okulların imkan ve şartlarına uygun nitelikte beden eğitimi öğretmeni yetiştirmediklerini ifade etmişlerdir. Ayrıca lisans derslerini yürüten öğretim elemanlarının yeterli sayıda olmadıkları ve bazı derslerde nitelik bakımından yetersiz kaldıklarını ileri sürmüşlerdir.  Beden eğitimi öğretmenleri beden eğitimi ve spor öğretmenliği bölümlerinin tesis ve sosyal imkânlar açısından problemlerin olduğunu belirtmişlerdir.