bluuebunny/crossref_metadata_2025 huggingface dataset:
Remote functional results of septoplasty performed taking into account the aerodynamic analysis of the nasal cavity
Authors: Svitlychnyi Oleksandr
Published: January 2020

The problem of nasal breathing disorders occupies a leading place in otolaryngology. In modern conditions, insurance and evidence-based medicine is acquiring the urgency of searching for objective methods of investigating the function of nasal breathing at the stages of preoperative planning. The development of rhinomanometric methods of investigation makes it possible to increase the functional efficiency of septoplasty.
Purposes: To develop a procedure for preoperative aerodynamic analysis of the nasal cavity on the basis of PARM and CT analysis and to evaluate the remote functional results of septoplasty performed taking into account the obtained data.
Materials and methods: The article presents the results of a study of 160 patients who underwent septoplasty within 3 years. In the main group, a survey was carried out on the NOSE scale, rhinomanometric studies with a complex of functional samples and analysis of computer tomograms. Based on the data obtained, their surgical treatment was performed (84 patients). Further, the functional results of septoplasty in the main group were compared with the results in the group of patients who underwent septoplasty without taking into account aerodynamic and tomographic analysis (76 patients).
Results: According to the results of a comparative analysis of the data of the state of the nasal breathing function, it is established that the above procedure allows more accurate estimation of the aerodynamic features of the nasal cavity and to determine the localization of pathological nasal resistance in the nasal breathing structure.
In turn, this allows objectively to plan and conduct septoplasty, which positively affects its functional efficiency and reduces the risk of development of unsatisfactory results in the long term after the operation.
Conclusion: When performing surgical interventions on the nose wall, taking into account the data of the anterior active rhinomatometry with the complex of functional tests and tomographic analysis, the total indicator for 3 years after the operation of unsatisfactory functional results was 3.57%, with a similar index of 13.16% in the course of operations without taking into account the above indicators (level of reliability р=0.0133<0,05).
Humoral factors of innate immunity in the saliva of patients with infectious inflammatory respiratory diseases
Authors: Melnikov Oleg , Zabolotnaya Diana , Bredun Alexander , Bil Bogdan , Rylska Oksana , Timchenko Мarina , Faraon Inna
Published: January 2020

Introduction: In recently ears factors of innate immunity both cellular and humoral have been paid considerable attention as they are a protective barrier of a fast response and that is why they are largely concentrated at the intersection of the digestive tract and airways. The data concerning the activity level of factors of innate immunity in the upper airways affected by nonspecific inflammatory processes is insufficient and sparse and therefore the purpose of this research was to study the content of humoral factors of innate immunity in the oropharyngeal secretion (ORS) of patients with chronic infectious inflammatory diseases of the upper airways in remission.
Materials and Methods: There was an examination of 16 patients with chronic rhinosinusitis (CRS) of bacterial genesis (15-40 years old), 12 patients with rhinopharyngitis of post-viral genesis (8-16 years old), 12 people with scleroma from 30 tо 52 years of age (atrophic form), 10 patients with chronic tonsillitis in remission (from 10 to 33 years of age) and 11 patients of a control group (practically healthy donors from 12 tо 40 years of age).
The content of MIP-1b, defensin-1β, lactoferrin, lysozyme, α-interferon was studied in the nonstimulated OPS. Statistics were carried out using Mann-Whitney U-test.
Results: The greatest number of deviations in the decrease in the content of the examined nonspecific protective factors was found in cases of scleroma, chronic tonsillitis and chronic rhinosinusitis (p<0,05). The lack of protective humoral factors of innate immunity can be evidence of local immunodeficiency even in remission, which is a pathophysiological component of the maintenance of chronic inflammation.
Conclusion: The decrease int he quantitative composition of factors of innate immunity in the oropharyngeal secretion of patients with chronic infectious inflammatory diseases of the airways is an objective ground not only for a replacement therapy, but also for the use of immune response modifiers from photo-immune modulators to “genuine immune modulators” controlling the state of the factors of both innate immunity and immunoglobulins, primarily of secretory type, the level and functionality of various groups of immunocompetent and accessory cells.
Morphological and immunohistochemical features of cartilage tissue used in reconstructive surgery of the perforations of the tympanic membrane
Authors: Gornostay Ivan , Yudina Olga , Petrova Lyudmila
Published: January 2020

Relevance: The problem of graft choosing to close the eardrum defect in chronic purulent otitis media remains relevant today. In the literature there are few scientific studies that examine the graft nutrition mechanisms.
The purpose of this study was to study water flow features in the free lying fragmented cartilage graft used by us in myringoplasty.
Materials and methods: The mass of fragmented cartilage autotransplants prepared for tympanoplasty, having the same area, was measured using electronic scales before immersing them in a physiological solution and after immersion. An increase of the transplant mass wasafter wetting it in a physiological solution. Morphological and immunohistochemical studies were carried out in 30 cases grouped into three groups: native cartilage, crushed (fragmented) cartilage and crushed cartilage hydrated by physiological solution. The histological material was 90 tissue samples. The histological preparations were made from all the pieces to assess the morphological characteristics of the cartilage. An immunohistochemical study was also conducted with antibodies to aquaporins (AQP 1, AQP 3 and AQP 8) to identify the localization of endogenous water channels in the auricle cartilage and to identify the role and transport function of aquaporins.
Results: It is proved that the nutrition of loosely lying fragmented cartilage improves due to the capillary effect after crushing it, the adsorption of fluid by cartilage tissue increases due to the activation of aquaporins. For the first time, the localization of aquaporin AQP8 in the auricle cartilage was determined.
Evaluation of the regenerative capacity of the tissues of the external auditory canal and tympanic membrane in patients with chronic otitis media
Authors: Gornostay I. , Vladimirskaya T. , Yudina O. , Petrova L.
Published: January 2020

Relevance: It is noted that the condition of the skin, the external auditory canal bone, the eardrum residues, that is, the tissues, from which the graft must first receive nutrition, largely determine the myringoplasty result.
Purpose: to assess the regenerative ability of the external auditory canal and tympanic membrane tissues in patients with chronic otitis media.
Materials and Methods: The migration ability of the external auditory canal and tympanic membrane tissues study was carried out in 98 patients with acute tympanic membrane perforation using a tissue staining test. In patients with chronic otitis media the staining test was performed before the operation. The external auditory canal skin in the bone part and the tympanic membrane residues were taken in patients of all groups in myringoplasty for immunohistochemistry.
The quantitative assessment of the biomolecular markers expression was performed by the digital image analyzing. It was obtained by a Leica DMLS microscope with software (Germany) and a JVC digital camera (the magnification of 200 times and a minimum number of view fields 5 in each microslide) using «positive pixel count» and morphometry software Aperio Image Scope.
Results: It was noted that in cases where the perforation was not closed, the migration ability of the tissues was impaired. A correlation was established between the regenerative ability of the epithelium by determining tissue biomarkers and migration ability. A high EGF level indicates a good regenerative ability and a positive test with staining. A low EGF level is noted in a negative test with staining. The state of the migratory ability of the external auditory canal epithelium and the tympanic membrane epithelium may indirectly indicate the regenerative ability of tissues and affect the tympanoplasty result. The staining test can serve as a prognostic criterion for the myringoplasty result, because it evaluates the regenerative ability state of the external auditory canal epithelium and eardrum epithelium.
Morphological structure of nasal polyps
Authors: Belousova A.
Published: January 2020

The morphological structure of the nasal polyps was studied. In adult patients, the vascular and glandular form of formations were isolated, in the childhood-vascular. Individual fibrosis polyps did not exist, the connective tissue, in one or another quantity is an integral structural component of all polyps. Eosinophilic tissue demonstrates the process's chronization and dystrophic changes, the eosinophils, as you know, promotes thrombus formation. Angiogenesis in the nasal polyps may be due to the use of therapeutic agents, for example, vasoconstrictors that affect the blood vessel tone, microcirculation, stimulating proliferative processes.
Detection of concomitant pathology of the middle ear according to tympanometry in children with hoarseness
Authors: Shidlovskaya Tetiana , Kurenyova Kateryna , Poimanova Elena , Molochek Yurii
Published: January 2020

Aim: to study of the state of the vocal apparatus in children with hoarseness using videolaryngoscopy and assessment of the state conducting part of the auditory analyzer according impedance audiometry.
Materials and methods: 24 children aged 4 to 10 years old were examined, whose parents complained of hoarseness in children (from several weeks to 1 year). Perceptual voice assessment in children showed hoarseness of the voice of varying degrees. Videolaryngoscopic examination was performed using a videolaryngoscope of the company «Karl Shtorz» (Germany), impedancemetry – using a clinical impedancemeter «Siemens SD-30» (Germany).
Results: After examining the state of the voice apparatus and the middle ear in children with complaints about the hoarseness, we have found that according to videolaryngoscopy, they have changes in the form of swollenness, a slight hyperemia of vocal folds. According to the impedance measurement, in 17 out of 24 patients, a tympanogram of type «C» was detected, and in 7 of them there was a pronounced reduction of compilation of the tympanogram, indicating certain violations in the sound conduction system.
Conclusion: When examining children with voice impairment, it is important to adhere to a comprehensive approach to diagnosis and to evaluate not only the state of the vocal apparatus, but also to remember the possible accompanying pathology of the nasopharynx, the nose and the auditory analyzer.
Optimal therapy of inflammatory diseases in the risk groups
Authors: Bezshapochny Sergey , Hychak Irina
Published: January 2020

Topicality: Pregnant women are at increased risk of susceptibility to inflammatory diseases of the pharynx.
Unfortunately, there are currently no approved protocols for the treatment of ENT diseases for such patients in Ukraine. It is very important to choose a safe and effective drug with minimal absorption in to the general blood flow. Another important point for the doctors the legal aspect, namely, the absence of contraindications to the appointment of pregnant women in the instructions for use of the medicine. These criteria are met by Celista spray for a throat, which is based on the active substance miramistin (0.1 mg/ml).
Materials and methods: We conducted a study that involved 30 pregnant women. These lection criteria were pregnant women from I to III trimester with a diagnosis of acute pharyngitis / tonsillitis / tonsillopharyngitis, up to 5 days after the disease, 0-3 points on a modified McAizek-Center scale, voluntary consent and adequate attitude to the study. All patients were prescribed topical irrigation of Celista spray x 4 times a day. The examination complex included subjective assessment of the condition on a 10-point visual-analogue scale, symptom severity assessment was performed using a questionnaire on a 4-point scale by criteria such as sore throat, burning, coughing (0 – no symptom, 1 – the symptom is poorly expressed, 2 – the symptom is moderately expressed, 3 – the symptom is strongly expressed). Objective examination included assessment of the condition by criteria such
as hyperemia of the posterior pharyngeal wall; hypertrophy of the follicles of the posterior wall of the pharynx; hypertrophy and swelling of the tonsils; regional lymphadenitis for 0; 3; 5; 7 days.
Results: It was found that the pain index decreased by 1.6 points, laceration in the throat – by 1.78 points, cough – by 0.3 points after treatment. A similar tendency was observed in the objective status: hyperemia of the posterior pharyngeal wall decreased by 1.5 points, hypertrophy of the pharynx follicles – by 1.27 points, hyperemia and swelling of the tonsils – by 0.8 points, regional lymphadenitis – by 0.5 points.
Conclusion: Thus, given that the absorption of Celista spray is actually absent, the drug has no contraindications for prescription during pregnancy, and based on our results, we can confirm the effectiveness of its use during pregnancy for the local treatment of acute inflammatory diseases of the pharynx in pregnant women in any period.
Hubungan Kepatuhan Minum Obat Dengan Kesembuhan Pasien Tuberkulosis Paru BTA Positif Di Puskesmas Delanggu Kabupaten Klaten
Authors: Widiyanto Aris
Published: January 2020

Abstract: Compliance Take Medicine The, Recovering, Positive Tuberculosis TB lung BTA. Object This research is to know the relationship of among compliance take medicine recovered is a patient of positive TB lung BTA in Puskesmas Delanggu of Sub-Province Klaten. The method this is analytic observational with the approach of research of cross-sectional. Sample in this research is patient of positive TB lung BTA which is registered in register TB Puskesmas Delanggu in the year 2012 which have followed the program DOTS and have finished its medication in the year 2013. The technique of Intake sample in this research is random sampling by sample counted 38 respondent. Technique analysis in this research is Chi-Square. Patient TB in Puskesmas Delanggu Klaten most obedient take medicine counted 25 responders (65,8%) and recovering of positive patient TB BTA most recovering counted 32 responders (84,2%). There is a relationship between compliance take medicine recovered is positive patient TB BTA in Puskesmas Delanggu Klaten. This Matter proven by value significant (P) 0.006 by = 5% hence P < 0.05. Compliance takes medicine to influence the story recovering of positive patient TB BTA in Puskesmas Delanggu Klaten.
Uji Aktifitas Tabir Surya Dan Stabilitas Fisik Formula Gel Semprot Dari Ekstrak Temugiring (Curcuma Heyneana Val.) Dan Ekstrak Kayu Manis (Cinnamomum Burmanii Nees.) Dengan Kombinasi Karbopol Dan HPMC.
Authors: Rusita Youstiana Dwi , Suhendriyo Suhendriyo
Published: January 2020

Abstract : Spray Gels, Sunscreens, Physical Stability, Rhizome Temugiring And Cortex Kayumanis. Excessive sun exposure can harm human skin, for skin damage can occur after exposure, namely in the form of burning or skin Erythema which is the onset of symptoms of degradation of cells and tissues. Sunscreen preparations have benefits to protect skin from exposure to ultraviolet rays and also contains antioxidants. Cinnamon (Cinnamomum burmanni Nees.) that has the activity of sunscreen, because it contains the compound sinamaldehid in addition also have activity as antioxidant. Rhizome temugiring (Curcuma Heyneana Val.) contain a flavanoid with fairly high antioxidant activity. Preparation of the gel has a number of advantages including not sticky and gels have a steady flow of tiksotropik and pseudoplastik i.e. solid gel when it is stored and will soon melt away when beaten. Spray technique is one of the new material has advantages which allow preparations sprayed with the dispersed evenly without needing to contact directly to flatten. Base that is often used in the making of gel karbopol and HPMC, among others. This type of Research design is a True Experiment. The formula that is used, there are three types with a combination of karbopol and HPMC. The research of spray gel extract kayumanis and extract temugiring on physical organoleptic stability Formula I red the typical smell of condensed form, kayumanis, part or a little murky, there are some air bubbles and cool on the skin when sprayed. Formula II, color of red brick the distinctive aroma preparations kayumanis, condensed form, no turbid and slightly cold when air bubbles, didispersikan to the skin; Test the viscosity Formula I 4000mPas, Formula II 1000 mPas, Formula III 1500mPas; Power test scatterplot latched into a Formula I attached did not drip to the formulation II is slightly attached and dripping, Formula III wasn't too attached to or flow; Test the spray pattern, the Formula I and II pattern that is formed is not round spread, Formula III pattern formed round spread; Its homogeneity test Formulation I, II, and III there are no particles; Irritation test Formulation I, II, and III the absence of symptoms of irritation. As for testing the stability of the antioxidant Formula I average IC50 values 1.21 SPF value average value, Formula II 10.48 IC50 value of 1.23 average average SPF 19.29, Formula III average IC50 values 1.18 SPF value average 12.51. Each formula no different IC50 values activity and SPF with the combination of karbopol and HPMC. Physical stability test and a good antioxidant formula III is with a combination of Karbopol 50% and 50% HPMC
Pengaruh Terapi Tambahan Asam Folat Dan Kobalamin Terhadap Gejala Skizofrenia Kronik
Authors: Hidayati Betty , Sudiyanto Aris , Fanani Moh.
Published: January 2020

Abstract: Folic Acid, Cobalamin, Symptoms, Schizophrenia. Schizophrenic patients have low levels of folic acid and cobalamin. Deficiency of folic acid and cobalamin can cause neurological and psychiatric disorders. Supplementation of folic acid and cobalamin may provide therapeutic benefits through different mechanisms of current treatment regimens. To assess the effectiveness of additional therapies of folic acid and cobalamin in improving the negative symptoms and length of stay of chronic schizophrenic patients. This study was an experimental study with randomized controlled trial group, pre-post test design. The intervention group had significant PANSS score improvementin positive symptoms (p = 0,01), negative symptoms (p = 0,004), general psychopathologies (p = 0,01) and PANSS total score (p = 0,014) subscales. ONE-WAY ANAVA statistic analysis result shows significant reduction in all four subscales (p = 0,000). Adding folic acid and vitamin B12 as adjuvant therapy with standard antipsychotic medication effective in reducing chronic schizophrenia symptoms.
Pengembangan Formula Wedang Secang Sebagai Minuman Kemasan Rendah Kalori
Authors: S Nutrisia A , Dewi Indri Kusuma , Rusita Youstiana Dwi
Published: January 2020

Abstract: Wedang Sappanwood, Physical Stability, Stability of Antioxidant, Test Hedonik, Low in Calories. Wedang sappanwood is a traditional drink of Indonesia, especially from the region of Central Java, which is made from the wood of caesalpinia sappan (Sappan L caesalpia) which gives a fresh red color like wine (wine). In addition to wood, sappanwood in wedang sappanwood also there are other spices that serves as a flavor enhancer. Empirically wedang sappanwood can be efficacious for preventing and minimizing the occurrence of degenerative disease through its activity as antioxidant and lowering blood sugar so that the necessary development of other caesalpiniasappan became preparations down ready low-calorie drink that is safe for diabetics. This research aims to develop preparations Wedang Sappanwood As lowcalorie Beverages in view of physical stability, stability of antioxidant and consumer acceptance (test hedonik). Test results on hedonik parameter that gets the highest value is the color of the material, then followed its homogeneity, the aroma, viscosity, and most smaller parameter flavor. The physical test result wedang sappanwood in Weeks 0 through Sunday XII shows the results organoleptc the smell of stale spices, brown color, liquid form, there are deposits of liquid, viscosity 1 cp, and pH of 4.23. Test results on hedonik parameter that gets the highest value is the color of the material, then followed its homogeneity, the aroma, viscosity, and most small parameter flavor. Test of antioxidants in 0 to month decline to III activities antioxidant it is characterized with a price less than the CI50 150 ppm of antioxidant activities are categorized, so weak.
Gangguan Pola Napas Tidak Efektif Pada Pasien Acute Myocard Infark (AMI)
Authors: Nurani Vera Budi , Setyorini Yuyun , Rifai Akhmad
Published: January 2020

Background: Acute Myocard Infarction (AMI) is the death of cardiac muscle cells due to long-lasting ischemia due to grafting in the coronary arteries. One of the nursing interventions is giving proper oxygen because it affects the condition of the patient who is short of breath. The aim of this study was to describe nursing care in patients with Acute Myocard Infarction (AMI) with impaired breathing disorder. Methods: This research uses data analysis method that is comparing the result criteria achieved from two patients of Acute Myocard Infarction (AMI) who experienced ineffective breathing disorder and then compared with case study journal or other sources. Result: Based on interview and observation it is concluded that with the same nursing diagnoses and implementation there are differences in outcomes and responses between the intervention group and the control group. Suggestion: Suggestions put forward in this study is the need to pay attention to accuracy in conducting assessment to maximize data to determine the priority problems that occur in patients and interventions based ONEC (Observation, Nursing Treatment, Education, Collaboration).
Faktor Risiko Prenatal Perinatal Dan Postnatal Pada Kejadian Cerebral Palsy
Authors: Trisnowiyanto Bambang , Purwanto Yohanes
Published: January 2020

Background: Cerebral Palsy (CP) is a disability disorder motor motorization is most common in children with a prevalence of 2-3 per 1000 live births. The term CP is explained as a group of movement and posture disorders that are often accompanied by impaired sensation, perception, cognition, communication, behavior, epilepsy, and secondary disorders of the musculoskeletal system. Disorders of CP occur in the immature central nervous system with non-progressive traits occurring in the prenatal, perinatal, and postnatal period. Methods:  The purpose of this study is to determine how much prenatal risk factors, perinatal, and postnatal events in CP at the Kitty Center Clinic in Jakarta for 5 year (2013 - 2017). Result: An observational descriptive study, which described prenatal perinatal, and postnatal risk factors for CP events at the Kitty Center Clinic in Jakarta for a period of 5 years (2013-2017) with a total of 523 study subjects. Based on the analysis of data obtained, based on the type of CP 35% quadripelgia spastic, 36% spastic diplegia, 6% spastic hemiplegia, 9% athetosis, and 14% hypotonia. Based on sex 62% are men, and 38% are women with a ratio of 1.6: 1.0. Based on the age of the child 11% <2 years, 34% 3-6 years, 33% 7-12 years, and 22%13-18 years. Conclusion:  Based on risk factors of 62% prenatal, 25% perinatal, and 12% postnatal. Prenatal risk factor is the biggest risk factor as much as 62% which causes Cerebral Palsy at the Kitty Center Clinic in Jakarta.
Perubahan Hemodinamika Pada Pasien Yang Dilakukan Terapi Hemodialisa Di Ruang Hemodialisa RSUD Dr. Moewardi
Authors: Maharsi Endah Dwi , Hartono Hartono
Published: January 2020

Abstract: Hemodynamic, Hemodyalisis. According to calculation of Pernefri on 2013, there are about 19.621 chronic renal failure patients which they need routine hemodialysis, over of 53% of patients is under 54 years old. Recently, hemodialysis treatment get rapidly developing, but there are many health problem on patients when they get hemodialysis treatment. Patients often get some complication such as hemodynamic problem. The purpose of this research is to 1) to discribe the characteristics of the gender, age 2) to discribe the hemodynamic (sistole, diastole, MAP, RR, HR) of pre and post hemodialysis 3) to analize the hemodynamic changes pre and post hempdyalisis treatment. This type of research is quasy experiment with one group pretest – posttest design. The results of the research is there are hemodynamic changes in patients done hemodyalisis at the hemodialysis unit in Dr. Moewardi Hospital of Surakarta. This is proven by testing paired samples t-test (systole, MAP, HR) which obtained the value of p < 0,05 and wilcoxon test (diastole, RR) which obtained the value of p < 0,05. According to the test of paired samples t-test and Wilcoxon test if p < 0,05, then the provision of therapy hemodialysis influential to changes in blood pressure. Conclusion. There is hemodynamic changes in patient done hemodyalisis at the hemodialysis unit dr.Moewardi Hospital.
Pengaruh Senam Diabetes Melitus (DM) Terhadap Perubahan Tekanan Darah Pada Pasien DM TIPE 2 Di Persadia Unit RSUD Dr. Moewardi Di Surakarta Tahun 2015
Authors: Afifah Amalia Nuril , Rifa’i Akhmad
Published: January 2020

Abstract : Type 2 Diabetes Mellitus, Blood Pressure, Gymnastics Diabetes. Diabetes Mellitus is a chronic metabolic disease or disorder with multiple etiologies is characterized by high blood sugar levels. World Health Organitation (WHO) said Indonesia ranks the seventh in the world as a country with the number of people with diabetes mellitus. More than 50% of patients with type 2 diabetes have hypertension (Sweetman, 2009). Management of diabetes disease that has been known there are three ways, namely arranging food, exercise, and medication. Exercise can cause the growth of new capillary blood vessels so as to reduce the blockage in the blood vessels which means it can lower blood pressure. The Objective of the research is to explain the influence of diabetes mellitus exercise to changes in blood pressure in patients with Type 2 diabetes mellitus in Persadia Hospital Dr. Moewardi Surakarta 2015. This type of research is quasy exsperiment to design one group pre and post test design, and data analysis used is frequency distribution univariate and bivariate test with paired samples t-test. Results of this study had a effect of diabetes mellitus exercise to changes in blood pressure in patients with Type 2 diabetes mellitus in Persadia Hospital Dr. Moewardi Surakarta. This is evidenced by paired sample t-test which obtained p value systole 0.01 and diastole 0.018 (p <0.05).The conclusion of the research there is the influence of diabetes mellitus exercise to changes in blood pressure in patients with Type 2 diabetes mellitus in Persadia Hospital Dr. Moewardi Surakarta.
Kecerdasan Emosional Dan Coping Caregiver Pada Pasien Stroke Hemoragik DI RSUD Soediran Mangun Sumarso Wonogiri
Authors: Nugraha Kristna Adi , Patriyani Ros Endah Happy
Published: January 2020

Abstract : Caregiver, Coping, Emotional Intelligence. Stroke acute attack caused physical disability and mental disability. The state will required caregiver assistance. Stroke patients will require treatment time is long enough so that will make the caregiver feel bored and empathy will be reduced. Bored in a long time will cause disturbed emotional. The Purpose of Research to investigate the relationship between emotional intelligence and coping caregivers for patients with hemorrhagic stroke in RSUD Soediran Mangun Sumarso Wonogiri. This research used correlation description with cross-sectional. The Research Subject were caregivers for patients with hemorrhagic stroke in RSUD Soediran Mangun Sumarso Wonogiri. Research carried out for a month. Sampling technique used total sampling and obtained 68 respondents. Research instruments used questionnaries. The result of emotional intelligence (73,5%) and coping (82,4%) in a good result. Spearman Rho test showed relationship between emotional intelligence and coping, significance level 0,042 and corellation 0,247. Low relation between emotional intelligence with coping caregivers for patients with hemorrhagic stroke in RSUD Soediran Mangun Sumarso Wonogiri. The next research, expected to add variable about characteristics of caregiver that affect the emotional intelligence and coping.
Kecemasan Dan Depresi Pada Penderita Diabetes Mellitus Tipe 2 Yang Mengalami Disfungsi Seksual Di Puskesmas Sibela Kota Surakarta
Authors: Insiyah Insiyah , Hastuti Rini Tri
Published: January 2020

Background: The various symptoms will be experienced by patients with diabetes mellitus type 2 following they suffer from the disease. The symptoms include symptoms of anxiety and depression. During suffering from diabetes mellitus type 2, the patients also experienced the complication of the disease that effects the quality of life. Good management of the disease is very important to decrease mortality and morbidity. WHO stated that there is an increase of prevalence of diabetes mellitus type 2 in developing countries including Indonesia. This research aims to know the relationship between anxiety and depression to sexual dysfunction among woman with diabetes mellitus type 2 in Sibela Public Health Centre in Surakarta City. This research was also conducted to describe the level of anxiety, depression and sexual dysfunction among women with diabetes mellitus. Method: this research is non-eksperimen with a descriptive correlational design that describes research based on the distribution and then finds a correlation between one variable and other variables. Chi-Square SPSS (Statistical Program For Social Science) version 18 was utilized to analyze the data. Result: showed that there a correlation between anxiety and sexual dysfunction among women with diabetes mellitus with p-value = 0,002 ( p< 0,05). Conclusion: There was also correlation between depression and sexual dysfunction among women with diabetes mellitus with p-value = 0.000 (p < 0,05). Identification of the symptoms of anxiety, depression, sexual dysfunction is important in order to plan appropriate intervention to deal with the problem.
Pengaruh Pemberian Extrak Jahe Dan Kacang Hijau Terhadap Pengurangan Mual Pada Ibu Hamil Semester 1 Di Puskesmas Ngawen 2 Wonosari Gunung Kidul
Authors: Handajani Sih Rini , Astuti KH Endah Widhi
Published: January 2020

Background: Nausea and vomiting are common discomforts experienced by 50% of pregnant women.  Emesis gravidarum will gain weight into hyperemesis gravidarum.  Management to overcome the discomfort of nausea and vomiting in the first trimester of pregnancy is to use pharmacological and non-pharmacological therapies including ginger drink and green beans.  The purpose of this study was to determine the effect of ginger drink and green beans on the frequency of nausea and vomiting in trimester pregnant women. Methods: Used in this study was quasy experiment with a time series pretest-posttest design approach.  The population in this study was TM I pregnant women in the Ngawen II health center. The sample in this study was first trimester pregnant women who experienced nausea and vomiting. The analysis of this study used the Wilcoxon and Kruskal-wallis test. Results: Showed there was an effect of giving ginger drink and green beans to the frequency of nausea vomiting in first trimester pregnant women with p value 0.01 <α with ginger drink being the most influential in post hoc nausea frequency of vomiting 6.67 compared to green beans and standard drugs. Conclusion: Administration of ginger drink and green beans has an effect on reducing the frequency of nausea and vomiting in first trimester pregnant women.
PERBANDINGAN FINANCIAL DISTRESS PADA PT DUTA PERTIWI, Tbk DAN PT JAYA REAL PROPERTY, Tbk DENGAN MENGGUNAKAN METODE SPRINGATE
Authors: Sinaga Rina Melani , Inrawan Ady , Astuti Astuti , Sianipar Ruth Tridianty
Published: January 2020

Tujuan penelitian ini adalah 1) Untuk mengetahui gambaran financial distress pada PT Duta Pertiwi, Tbk dan PT Jaya Real Property, Tbk. 2) Untuk mengetahui faktor yang menyebabkan perbedaan financial distress pada PT Duta Pertiwi, Tbk dan PT Jaya Real Property, Tbk. Penelitian ini merupakan penelitian deskriptif kualitatif. Financial Distress diukur dengan menggunakan Metode Springate. Hasil penelitian menunjukkan bahwa 1) PT Duta Pertiwi, Tbk diindikasi tidak bangkrut, sedangkan PT Jaya Real Property, Tbk diindikasi menghadapi ancaman kebangkrutan yang serius. 2) Faktor yang menyebabkan perbedaan financial distress PT Duta Pertiwi, Tbk dan PT Jaya Real Property, Tbk adalah nilai modal kerja bersih, peningkatan utang usaha pihak ketiga, penurunan kas dan setara kas, peningkatan beban usaha, serta efisiensi pengelolaan aset.Kata kunci: Financial Distress, Metode Springate.
DETERMINAN KEBIJAKAN DIVIDEN PADA SEKTOR NONKEUANGAN
Authors: Pratama Ahmad Aziz Putra
Published: January 2020

This study aims to determine the effect of company size, leverage, growth opportunities, return on on equity, price earnings ratio, quick ratio and free cash flow on dividend policy in non-financial companies listed on the Indonesia Stock Exchange during the 2013-2018 period. This study uses 122 with a total of 732 observations using purposive sampling method with multiple linear regression models. This study was processed using SPSS 25. The independent variables in this study are size, leverage, growth opportunities, ROE, PER, quick ratio, and free cash flow. The dependent variable in this study is dividend policy. Based on the analysis results, it can be concluded that size and PER have a significant positive effect on dividend policy, quick ratio and free cash flow have a positive and insignificant effect on dividend policy, while leverage and ROE have no significant negative effect on dividend policy, and growth has a significant negative effect on dividend policy.
ANALISIS KESALAHAN MENYELESAIKAN PENGURANGAN PECAHAN BIASA DI SDN 64 KOTA TIMUR KOTA GORONTALO
Authors: Nalole Martianty
Published: January 2020

Permasalahan dalam penelitian ini adalah “Bagaimana kesalahan dalam menyelesaikan pengurangan pecahan di SDN 64 Kota Timur Kota Gorontalo?. Penelitian ini bertujuan untuk mengetahui kesalahan dalam menyelesaikan pengurangan pecahan di SDN 64 Kota Timur Kota Gorontalo. Pendekatan penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif dan prosedur penelitian yakni wawancara dan dokumentes. Hasil penelitian menunjukkan bahwa dalam menyelesaikan pengurangan pecahan terdapat banyak kesalahan yang dilakukan siswa yaitu kesalahan konseptual diantaranya siswa tidak memahami makna soal yang diberikan. Dan kesalahan Prosedural yakni siswa tidak dapat merubah pecahan campuran menjadi pecahan biasa, dan salah dalam menghitung. Yang terdapat banyak kesalahan yaitu terdapat pada menyelesaikan soal cerita yakni 55% dari jumlah siswa kelas V kesalahannya tidak memahami makna soal yang diberikan. Disimpulkan bahwa dalam menyelesaikan pengurangan pecahan tmasih banyak siswa yang mengalami kesalahan yaitu kesalahan konseptual dan kesalahan prosedural.
PENINGKATAN KEMAMPUAN KOGNITIF ANAK USIA DINI MELALUI MEDIA KARTU ANGKA
Authors: Utami Febriyanti
Published: January 2020

Penelitian ini bertujuan untuk meningkatkan kemampuan kognitif anak dalam mengenal lambang bilangan melalui media kartu angka pada anak Kelompok A Kelompok Bermain PAUD Taman Sari I. Penelitian ini merupakan penelitian tindakan kelas dengan subjek penelitian anak Kelompok A sebanyak 15 anak yang terdiri dari 10 anak perempuan dan 5 anak laki-laki. Penelitian ini terdiri dari 2 siklus dengan masing-masing tahapan yaitu perencanaan, pelaksanaan, pengamatan dan refleksi. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi yang berupa lembar pengamatan kemampuan kognitif anak dalam mengenal lambang bilangan dan dokumentasi. Berdasarkan hasil penelitian yang dilakukan, kemampuan kognitif anak dalam mengenal lambang bilangan dapat meningkat dengan menggunakan media kartu angka. Hal ini ditunjukkan dengan meningkatnya rata-rata persentase kemampuan kognitif anak dalam mengenal lambang bilangan pada tahap pra siklus yaitu 26.7 % menjadi 57.7 % pada siklus I dan 86.7 % pada siklus II setelah dilakukannya tindakan dengan menggunakan media kartu angka dalam proses pembelajaran. Dengan demikian dapat disimpulkan bahwa penggunaan media kartu angka dapat meningkatkan kemampuan kognitif anak dalam mengenal lambang bilangan pada Kelompok A Kelompok Bermain Taman Sari I.
PENANAMAN PENDIDIKAN AGAMA DI TAMAN KANAK_KANAK
Authors: Samsiah
Published: January 2020

Penanaman Pendidikan agama pertama dan utama berasal dari keluarga, orang tua ketika anaknya masuk usia Taman Kanak-Kanak  dapat bekerjasama dengan Taman Kanak kanak  dalam penanaman pendidikan agama, hal ini dikarenakan orang tua menyadari penanaman pendidikan agama sejak dini jauh lebih baik dari sesudah anak dewasa. Penelitian ini dilakukan di Taman Kanak-Kanak Qurratu a’yun yang di dalam kegiatan belajarnya terdapat muatan penanaman pendidikan agama. penelitian ini menggunakan penelitian kualitatif, data yang terkumpul dan analisisnya lebih bersifat kualitatif. Peneltian ini bertujuan untuk memberikan informasi  bagaimana penanaman pendidikan agama di Taman Kanak-Kanak Qurratu a’yun. Hasil penelitian menunjukkan bahwa penanaman pendidikan agama di Taman Kanak-Kanak Qurratu a’yun yaitu melaksanakan kegiatan pembelajaran dengan muatan agama yaitu mengajarkan  : a) Tauhid, b) Hafalan Surah,  c) Hafalan hadist, d) Hafalan Bacaan sholat, e) Hafalan Doa harian, f) Adab Islami,  g) Bahasa arab dan bahasa lnggris, dan h) Kisah Teladan.
KEMAMPUAN SISWA BERMAIN DRAMAMELALUI MODEL ROLLE PLAYING DI KELAS V SD INPRES 2 RUSAKENCANA KABUPATEN BANGGAI PROVINSI SULAWESI TENGAH
Authors: Mohamad Sumarni , Ratna Marianingsih
Published: January 2020

Penelitian ini bermaksud untuk mendeskripsikan tingkat kemampuan siswa dalam bermain drama. Jenis penelitian yang digunakan adalah penelitian deskriptif kualitatif. Hasil penelitian menunjukkan bahwa kemampuan siswa bermain drama telah mencapai tujuan pembelajaran. Hal ini ditunjukkan pada observasi kemampuan siswa yaitu, 12 siswa atau 60% siswa mampu bermain drama, 8 siswa atau 40% siswa kurang mampu dan 0% siswa tidak mampu.Dari hasil penelitian dapat disimpulkan bahwa teknik guru dalam pembelajaran drama sudah tepat dan mencapai tujuan pembelajaran
Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo
Authors: Sailer Alexander , Ermer Franziska , Kraus Yvonne , Bingham Rebekkah , Lutter Ferdinand H , Ahlfeld Julia , Thorn-Seshold Oliver
Published: January 2020

Background: Hemithioindigo is a promising molecular photoswitch that has only recently been applied as a photoswitchable pharmacophore for control over bioactivity in cellulo. Uniquely, in contrast to other photoswitches that have been applied to biology, the pseudosymmetric hemithioindigo scaffold has allowed the creation of both dark-active and lit-active photopharmaceuticals for the same binding site by a priori design. However, the potency of previous hemithioindigo photopharmaceuticals has not been optimal for their translation to other biological models.

Results: Inspired by the structure of tubulin-inhibiting indanones, we created hemithioindigo-based indanone-like tubulin inhibitors (HITubs) and optimised their cellular potency as antimitotic photopharmaceuticals. These HITubs feature reliable and robust visible-light photoswitching and high fatigue resistance. The use of the hemithioindigo scaffold also permitted us to employ a para-hydroxyhemistilbene motif, a structural feature which is denied to most azobenzenes due to the negligibly short lifetimes of their metastable Z-isomers, which proved crucial to enhancing the potency and photoswitchability. The HITubs were ten times more potent than previously reported hemithioindigo photopharmaceutical antimitotics in a series of cell-free and cellular assays, and allowed robust photocontrol over tubulin polymerisation, microtubule (MT) network structure, cell cycle, and cell survival.

Conclusions: HITubs represent a powerful addition to the growing toolbox of photopharmaceutical reagents for MT cytoskeleton research. Additionally, as the hemithioindigo scaffold allows photoswitchable bioactivity for substituent patterns inaccessible to the majority of current photopharmaceuticals, wider adoption of the hemithioindigo scaffold may significantly expand the scope of cellular and in vivo targets addressable by photopharmacology.
Variations in the Width, Density, and Direction of the Palomar 5 Tidal Tails
Authors: Bonaca Ana , Pearson Sarah , Price-Whelan Adrian M. , Dey Arjun , Geha Marla , Kallivayalil Nitya , Moustakas John , Muñoz Ricardo , Myers Adam D. , Schlegel David J. , Valdes Francisco
Published: January 2020

Stars that escape globular clusters form tidal tails that are predominantly shaped by the global distribution of mass in the Galaxy, but also preserve a historical record of small-scale perturbations. Using deep grz photometry from DECaLS, we present highly probable members of the tidal tails associated with the evaporating globular cluster Palomar 5. These data yield the cleanest view of a stellar stream beyond ≈20 kpc and reveal: (1) a wide, low surface-brightness extension of the leading tail; (2) significant density variations along the stream; and (3) sharp changes in the direction of both the leading and the trailing tail. In the fiducial Milky Way model, a rotating bar perturbs the Palomar 5 tails and can produce streams with similar width and density profiles to those observed. However, the deviations of the stream track in this simple model do not match those observed in the Palomar 5 trailing tail, indicating the need for an additional source of perturbation. These discoveries open up the possibility of measuring the population of perturbers in the Milky Way, including dark-matter subhalos, with an ensemble of stellar streams and deep photometry alone.
Filling the Magnetospheres of Weak Pulsars
Authors: Chen Alexander Y. , Cruz Fábio , Spitkovsky Anatoly
Published: January 2020

Recent advances in numerical algorithms and computational power have enabled first-principles simulations of pulsar magnetospheres using particle-in-cell techniques. These ab initio simulations seem to indicate that pair creation through photon–photon collision at the light cylinder is required to sustain the pulsar engine. However, for many rotation-powered pulsars, pair creation operates effectively only near the stellar surface where magnetic field is high. How these “weak pulsars” fill their magnetospheres without efficient photon–photon pair conversion in the outer magnetosphere is still an open question. In this paper, we present a range of self-consistent solutions to the pulsar magnetosphere that do not require pair production near the light cylinder. When pair production is very efficient near the star, the pulsar magnetosphere converges to previously reported solutions. However, in the intermediate regime, where pair supply is barely enough to sustain the magnetospheric current, we observe a time-dependent solution with a quasi-period about half of the rotation period. This new quasi-periodic solution may explain the observed pulsar death line without invoking multipolar components near the star, and can potentially explain the core versus conal emission patterns observed in pulsar radio signals.
Condensation of Atomic Carbon: Possible Routes toward Glycine
Authors: Krasnokutski Serge A. , Jäger Cornelia , Henning Thomas
Published: January 2020

Many organic molecules including amino acids and nucleobases are expected to be formed in astrophysical environments. In this article, we used both experimental and computational approaches to test the possibility of the glycine formation in the interstellar medium via C atom addition to ice mantels of dust particles. The reactions of C atoms with NH3 and H2 were studied experimentally. These reactions are found to be highly exothermic and barrierless, leading to the formation of the products CH2NH and HCH. These product molecules are formed in excited states and therefore could immediately take part even in chemical reactions with energy barriers. The CH2NH molecule is formed in the long-lived triplet state, which is above the most energetically favorable singlet state of about 20,918 cm−1 (∼250 kJ mol−1). Therefore, based on the results of quantum chemical computations the following two pathways can take place at low temperature. The first one is C + H2 → HCH followed by NH3 + HCH + CO2 → glycine. The second one is C + NH3 → CH2NH followed by CH2NH + CO + H2O → glycine or CH2NH + CO2 + H2 → glycine. The first pathway was also tested experimentally by adding C atoms to ice clusters containing H2, NH3, and CO2 molecules. The detection of the main mass peak of glycine supported the feasibility of the proposed pathway.
HST/STIS Capability for Love Number Measurement of WASP-121b
Authors: Hellard Hugo , Csizmadia Szilárd , Padovan Sebastiano , Sohl Frank , Rauer Heike
Published: January 2020

Data from transit light curves, radial velocity, and transit timing observations can be used to probe the interiors of exoplanets beyond the mean density, by measuring the Love numbers h
2 and k
2. The first indirect estimate of k
2 for an exoplanet from radial velocity and transit timing variation observations has been performed by taking advantage of the years-spanning baseline. Not a single measurement of h
2 has been achieved from transit light curves, mostly because the photometric precision of current observing facilities is still too low. We show that the Imaging Spectrograph instrument onboard the Hubble Space Telescope (HST) could measure h
2 of the hot Jupiter WASP-121b if only a few more observations were gathered. We show that a careful treatment of the noise and stellar limb darkening (LD) must be carried out to achieve a measurement of h
2. In particular, we find that the impact of the noise modeling on the estimation of h
2 is stronger than that of the LD modeling. In addition, we emphasize that the wavelet method for correlated noise analysis can mask limb brightening. Finally, using currently available data, we briefly discuss the tentative measurement of

in terms of interior structure. Additional observations would further constrain the interior of WASP-121b and possibly provide insights on the physics of inflation. The possibility of using the approach presented here with the HST provides a bridge before the high-quality data to be returned by the James Webb Space Telescope and PLATO telescope in the coming decade.