bluuebunny/crossref_metadata_2025 huggingface dataset:
Antiglycation potential of Indigoferin a, Indigoferin B and Indigoferin C natural products from Indigofera heterantha Brandis
Authors: Khan Ayesha , Khan Ajmal , Ahmad Manzoor , Ali Mumtaz , Farooq Umar , Khan Farhan Ahmad , Bukhari Syed Majid
Published: January 2021

Background

Diabetes is a long-lasting and serious disease that effect in worldwide individual lives, families, and societies. Hyperglycemia of diabetes mellitus produced Advance Glycation End Products that are associated with diabetic complications like neuropathy, nephropathy, retinopathy, and cardiovascular diseases.

Methods

In this study, the natural products isolated from of Indigofera heterantha Brandis, Indigoferin A (S1), Indigoferin B (S2) and Indigoferin C (S3) were evaluated for their in vitro antiglycation activity.

Results

The compounds exhibited a significant inhibitory activity against the formation of Advanced Glycation End-Products with IC50 values of 674.25 ± 3.2 μM, 407.03 ± 4.7 μM and 726.41 ± 2.1 μM, respectively. Here, important structure-activity relationship was observed, when the intramolecular hydrogen bonding interactions suppressed the antiglycation activity of compound S3. Thus, the study clearly demonstrates that the number and the position of substituents act as an assisting factor and directly influence the inhibitory activity of the natural product by altering the sugar or protein binding affinity.

Conclusions

This study explain first time the antiglycation inhibitory ability of chemical constituents isolated from I. heterantha and can be used for above late diabetic complications.
Perioperative abnormal electroencephalography in a later-stage elderly with septic shock: a case report
Authors: Kinoshita Hirotaka , Kushikata Tetsuya , Takekawa Daiki , Hirota Kazuyoshi
Published: January 2021

Background

Patients with sepsis often exhibit abnormal patterns of electroencephalogram (EEG). We report an abnormal EEG pattern in a later-stage elderly patient with septic shock and EEG analysis results.

Case presentation

An 88-year-old woman with bowel perforation underwent emergency Hartmann surgery. On admission to the operating room, she exhibited septic shock. Her bispectral index value was 30 before anesthesia induction, and the EEG displayed slow waves without burst and suppression throughout the surgery. The relative slow-wave ratio [spectral power (0.5–8 Hz)/(0.5–30 Hz)] from anesthetic induction to the end of surgery was 95.1%, whereas the relative alpha frequency [spectral power (8–13 Hz)/(0.5–30 Hz)] was only 2.4%. Although without preoperative neurological abnormalities, she developed postoperative delirium after admission to the intensive care unit.

Conclusions

Intraoperative continuous EEG monitoring in elderly patients with sepsis may be useful to predict sepsis-associated encephalopathy. Therefore, continuous EEG monitoring may improve neurological outcomes.
TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
Authors: Atkinson Rachel , Leung Jacqueline , Bender James , Kirkcaldie Matthew , Vickers James , King Anna
Published: January 2021

Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from the nucleus to the cytoplasm is a common feature of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The downstream in vivo cellular effects of this mislocalization are not well understood. To investigate the impact of mislocalized TDP-43 on neuronal cell bodies, axons and axonal terminals, we utilized the mouse visual system to create a new model of TDP-43 proteinopathy. Mouse (C57BL/6J) retinal ganglion cells (RGCs) were transduced with GFP-tagged human wild-type TDP-43 (hTDP-WT-GFP) and human TDP-43 with a mutation in the nuclear localization sequence (hTDP-ΔNLS-GFP), to cause TDP-43 mislocalization, with ∼60% transduction efficiency achieved. Expression of both hTDP-WT-GFP and hTDP-ΔNLS-GFP resulted in changes to neurofilament expression, with cytoplasmic TDP-43 being associated with significantly (P<0.05) increased neurofilament heavy expression in the cell soma, and both forms of altered TDP-43 leading to significantly (P<0.05) decreased numbers of neurofilament-positive axons within the optic nerve. Alterations to neurofilament proteins were associated with significantly (P<0.05) increased microglial density in the optic nerve and retina. Furthermore, expression of hTDP-WT-GFP was associated with a significant (P<0.05) increase in pre-synaptic input into RGCs in the retina. The current study has developed a new model that allows detailed examination of alterations to TDP-43 and will contribute to the knowledge of TDP-43-mediated neuronal alterations and degeneration.
Structural Characterization of Y29F Mutant of Thermoglobin from a Hyperthermophilic Bacterium Aquifex aeolicus
Authors: Muraki Norifumi , Takeda Kouta , Nam Dayeon , Muraki Megumi , Aono Shigetoshi
Published: January 2021

We have determined the crystal structure of thermoglobin (AaTgb) from a hyperthermophilic bacterium Aquifex aeolicus. Tyrosine and glutamine at the B10 and E7 position, respectively, are conserved in AaTgb as are the case of single domain hemoglobins (sdHbs). While the binding affinity of O2 or CO is affected by the replacement of Tyr29 in the distal heme pocket, wild type and Y29F variant of AaTgb show a similar binding affinity of imidazole.
THE IMPORTANCE OF INSTITUTIONAL INVESTORS DIVERSIFICATION IN THE DEVELOPMENT OF THE GOVERNMENT SECURITIES MARKET
Authors: Hincu Rodica , Litocenco Ana
Published: January 2021

The development of a government securities market is a complex process that is interrelated with the financial and market system development of each country. For many countries, this implies huge challenges that often are amplified by economic issues. For instance, some government securities markets rely on a few domestic banks for funding, which makes competition scarce, and transaction costs high. In addition to this, the lack of a sound market infrastructure may make specific actions to develop a government securities market premature and ineffective. At the same time, the insufficiency of institutional investors, low domestic savings rates, and lack of interest from international investors generate a small, highly homogeneous investor group, contrary to the diversity needed for an efficient market. Furthermore, economic instability, often accompanied by high fiscal deficits, rapid growth of the money supply, and a deteriorating exchange rate, weakens investor confidence and increases the risks associated with the development of a market for government securities. This article aims to describe the importance of a diversified investor base in developing a government securities market and to show the experience of the Republic of Moldova in this regard.
LIBERTARIAN PHILOSOPHY VERSUS PROPERTARIAN DOGMA: A FURTHER REPLY TO BLOCK
Authors: Lester J.C.
Published: January 2021

This replies to Block 2019 (B19), which responds to Lester 2014 (L14). The main issues in the, varyingly sized, sections are as follows. 1 Further explanations of critical rationalism, the theory of liberty, and problems with the non-aggression principle. 2.1 The relationships among law, morality, and libertarianism. 2.2 The objective invasiveness of low-level radiation and that it is, therefore, a proactive imposition (albeit trivial) if someone inflicts it on non-consenting people. 2.3 The objective and subjective aspects of proactive impositions; and how clashes can be resolved. 2.4 How liberty relates to risk and self-ownership. 2.5 Libertarian initial acquisition versus absolute property rights by labour-mixing. 2.6 Organisational note. 2.7 Libertarianism and mens rea. 2.8 Libertarian rectification versus lex-talionis doubling. 2.9 Indirectly clashing rights, self-preservation, trespasser-hiker, flagpole-grasper, and landmine-layer. 2.10 A logical point is not a moral point. 2.11 Pacifism and libertarianism. 3.1 A weak criticism of utilitarianism. 3.2 Hedonometers; approximate interpersonal comparisons of utility imply libertarianism; what a libertarian is; libertarian rankings. 4. Libertarian philosophy versus propertarian dogma. Coda: the need to take seriously the philosophical problems with propertarian-justificationist libertarianism. Readers that might be interested include those engaging in libertarian philosophy and those using the Rothbardian/Blockian theoretical approach to libertarianism.
SOCIAL PROTECTION OF THE FAMILY IN INTERNATIONAL AND EU LAW
Authors: Maj Elzbieta
Published: January 2021

People and families have been stricken by poverty from the dawn of time. As a result of the tragic events of World Wars I and II, the 20th century became the arena for the development of humanitarian law fundamentals. The most important international organizations, such as the United Nations, the International Labor Organization, and the Council of Europe, started operating in the post-war period. The first declarations and conventions referred to the issue of social protection on the ideological and axiological level and emphasized only a need to provide poor families and their members with social security. Over time, the normative dimension became specialized, both concerning the content and details of the proclaimed regulations. The article, which discusses the issue of social protection of the family from the perspective of basic international and EU laws, has a character of a review. The analysis of the selected legal acts is centered both on the territorial aspect, focusing on the universal, regional (European) and EU trends, and the temporal one – presenting the evolution of social protection programs over almost one hundred years. The study deals also with a question about the normative cohesion of the universal, regional (European) and EU systems, as well as their interrelations, that is to say: competition or mutual reception. The conclusions from the research give a positive answer and emphasize the development and specialization of social institutions, both on the universal and regional levels. Furthermore, the conclusions indicate that, during evolution, social proposals have moved from the ideological level towards detailed pragmatism, harmonizing the three legal protection systems. The dogmatic-legal method and theoretical-legal method have been applied to verify the problems and hypotheses formulated, owing to which it has been possible to carry out normative analyses and corroborate them with the doctrine of human rights and social law.
Threatening to burn the house down
Authors: Malhi Narpinder , Kiani Immad
Published: January 2021

Mr. X, age 61, is experiencing behavioral and psychological
symptoms of dementia, but so far none of the standard
treatment approaches have helped. What would you do next?
How practical drift and cognitive biases impact hospital hand hygiene compliance
Authors: Smith Charles
Published: January 2021

With hospital-acquired infections accounting for approximately 500 deaths a year in the UK, Charles Smith discusses how hand hygiene compliance can falter in hospitals and what can be done to minimise this effect.
MetGEMs Toolbox: Metagenome-scale models as integrative toolbox for uncovering metabolic functions and routes of human gut microbiome
Authors: Patumcharoenpol Preecha , Nakphaichit Massalin , Panagiotou Gianni , Senavonge Anchalee , Suratannon Narissara , Vongsangnak Wanwipa
Published: January 2021

Investigating metabolic functional capability of a human gut microbiome enables the quantification of microbiome changes, which can cause a phenotypic change of host physiology and disease. One possible way to estimate the functional capability of a microbial community is through inferring metagenomic content from 16S rRNA gene sequences. Genome-scale models (GEMs) can be used as scaffold for functional estimation analysis at a systematic level, however up to date, there is no integrative toolbox based on GEMs for uncovering metabolic functions. Here, we developed the MetGEMs (metagenome-scale models) toolbox, an open-source application for inferring metabolic functions from 16S rRNA gene sequences to facilitate the study of the human gut microbiome by the wider scientific community. The developed toolbox was validated using shotgun metagenomic data and shown to be superior in predicting functional composition in human clinical samples compared to existing state-of-the-art tools. Therefore, the MetGEMs toolbox was subsequently applied for annotating putative enzyme functions and metabolic routes related in human disease using atopic dermatitis as a case study.
Wastewater treatment alters microbial colonization of microplastics
Authors: Kelly John J. , London Maxwell G. , McCormick Amanda R. , Rojas Miguel , Scott John W. , Hoellein Timothy J.
Published: January 2021

Microplastics are ubiquitous contaminants in aquatic habitats globally, and wastewater treatment plants (WWTPs) are point sources of microplastics. Within aquatic habitats microplastics are colonized by microbial biofilms, which can include pathogenic taxa and taxa associated with plastic breakdown. Microplastics enter WWTPs in sewage and exit in sludge or effluent, but the role that WWTPs play in establishing or modifying microplastic bacterial assemblages is unknown. We analyzed microplastics and associated biofilms in raw sewage, effluent water, and sludge from two WWTPs. Both plants retained >99% of influent microplastics in sludge, and sludge microplastics showed higher bacterial species richness and higher abundance of taxa associated with bioflocculation (e.g.Xanthomonas) than influent microplastics, suggesting that colonization of microplastics within the WWTP may play a role in retention. Microplastics in WWTP effluent included significantly lower abundances of some potentially pathogenic bacterial taxa (e.g.Campylobacteraceae) compared to influent microplastics; however, other potentially pathogenic taxa (e.g.Acinetobacter) remained abundant on effluent microplastics, and several taxa linked to plastic breakdown (e.g.Klebsiella,Pseudomonas, andSphingomonas) were significantly more abundant on effluent compared to influent microplastics. These results indicate that diverse bacterial assemblages colonize microplastics within sewage and that WWTPs can play a significant role in modifying the microplastic-associated assemblages, which may affect the fate of microplastics within the WWTPs and the environment.
Covert cases of Severe Acute Respiratory Syndrome Coronavirus 2: An obscure but present danger in regions endemic for Dengue and Chikungunya viruses
Authors: Stringari Lorenzzo Lyrio , de Souza Michel Norbim , de Medeiros Junior Nésio Fernandes , Goulart Jaqueline Pegoretti , Giuberti Camila , Dietze Reynaldo , Ribeiro-Rodrigues Rodrigo
Published: January 2021

Background

The impact of SARS-CoV-2 in regions endemic for both Dengue and Chikungunya is still not fully understood. Considering that symptoms/clinical features displayed during Dengue, Chikungunya and SARS-CoV-2 acute infections are similar, undiagnosed cases of SARS-CoV-2 in co-endemic areas may be more prevalent than expected. This study was conducted to assess the prevalence of covert cases of SARS-CoV-2 among samples from patients with clinical symptoms compatible with either Dengue or Chikungunya viral infection in the state of Espírito Santo, Brazil.

Methods

Presence of immunoglobulin G (IgG) antibody specific to SARS-CoV-2 nucleoprotein was detected using a chemiluminescent microparticle immunoassay in samples from 7,370 patients, without previous history of COVID-19 diagnosis, suspected of having either Dengue (n = 1,700) or Chikungunya (n = 7,349) from December 1st, 2019 to June 30th, 2020.

Findings

Covert cases of SARS-CoV-2 were detected in 210 (2.85%) out of the 7,370 serum samples tested. The earliest undiagnosed missed case of COVID-19 dated back to a sample collected on December 18, 2019, also positive for Dengue Virus. Cross-reactivity with either Dengue virus or other common coronaviruses were not observed.

Interpretation

Our findings demonstrate that concomitant Dengue or Chikungunya outbreaks may difficult the diagnosis of SARS-CoV-2 infections. To our knowledge, this is the first study to demonstrate, with a robust sample size (n = 7,370) and using highly specific and sensitive chemiluminescent microparticle immunoassay method, that covert SARS-CoV-2 infections are more frequent than previously expected in Dengue and Chikungunya hyperendemic regions. Moreover, our results suggest that SAR-CoV-2 cases were occurring prior to February, 2020, and that these undiagnosed missed cases may have contributed to the fast expansion of SARS-CoV-2 outbreak in Brazil. Data presented here demonstrate that in arboviral endemic regions, SARS-CoV-2 infection must be always considered, regardless of the existence of a previous positive diagnosis for Dengue or Chikungunya.
Heterogeneous deniable authenticated encryption for location-based services
Authors: Jin Chunhua , Kan Ge , Chen Guanhua , Yu Changhui , Jin Ying , Xu Chengjie
Published: January 2021

The location-based services can provide users with the requested location information. But users also need to disclose their current location to the location-based service provider. Therefore, how to protect user’s location privacy is a major concern. In this paper, we propose a heterogeneous deniable authenticated encryption scheme called HDAE for location-based services. The proposed scheme permits a sender in a public key infrastructure environment to transmit a message to a receiver in an identity-based environment. Our design utilizes a hybrid encryption method combing the tag-key encapsulation mechanism (tag-KEM) and the data encapsulation mechanism (DEM), which is well adopted for location-based services applications. We give how to design an HDAE scheme utilizing a heterogeneous deniable authenticated tag-KEM (HDATK) and a DEM. We also construct an HDATK scheme and provide security proof in the random oracle model. Comprehensive analysis shows that our scheme is efficient and secure. In addition, we give an application of the HDAE to a location-based services system.
Mapping quantitative trait loci and predicting candidate genes for leaf angle in maize
Authors: Zhang Ning , Huang Xueqing
Published: January 2021

Leaf angle of maize is a fundamental determinant of plant architecture and an important trait influencing photosynthetic efficiency and crop yields. To broaden our understanding of the genetic mechanisms of leaf angle formation, we constructed a F3:4recombinant inbred lines (RIL) population to map QTL for leaf angle. The RIL was derived from a cross between a model inbred line (B73) with expanded leaf architecture and an elite inbred line (Zheng58) with compact leaf architecture. A sum of eight QTL were detected on chromosome 1, 2, 3, 4 and 8. Single QTL explained 4.3 to 14.2% of the leaf angle variance. Additionally, some important QTL were confirmed through a heterogeneous inbred family (HIF) approach. Furthermore, twenty-four candidate genes for leaf angle were predicted through whole-genome re-sequencing and expression analysis in qLA02-01and qLA08-01 regions. These results will be helpful to elucidate the genetic mechanism of leaf angle formation in maize and benefit to clone the favorable allele for leaf angle. Besides, this will be helpful to develop the novel maize varieties with ideal plant architecture through marker-assisted selection.
Sustainability, health and consumer insights for plant-based food innovation
Authors: Perez-Cueto Federico J.A.
Published: January 2021

Plant-based foods are part of a needed change in the food system. This opinion article addresses sustainability, health and consumer issues to inform plant-based food innovation and research. Consumers are key players in the food system. In 2020, consumers require that cues of sustainability be clearly addressed in food innovation. Consumers are more and more conscious of the detrimental effects of animal farming on the environment as well as the ethical issues resulting from poor animal welfare. Consumers want their products to be sustainable, healthy and conscious of animal welfare. Plant-based foods deliver on all fronts. Nevertheless, consumers have to deal with facilitators and barriers towards dietary change such as cooking skills, taste preference and family support.
Destinos Turísticos e Resiliência a Crises e Catástrofes
Authors: Paiva Catarina , Santos Norberto
Published: January 2021

Os incêndios de outubro de 2017 devastaram toda a Região Centro de Portugal, tendo registado severos impactos socioeconómicos ao nível local e regional, ao comprometer o normal funcionamento das atividades económicas. O sistema turístico desta região que, nos últimos anos, tem contribuído para um novo aproveitamento dos espaços rurais e para a regeneração do seu tecido socioeconómico, naturalmente, não escapou às perturbações que os incêndios criaram. No presente estudo, que se debruçou, essencialmente, sobre o território de Arganil, Oliveira do Hospital e Tábua, três dos concelhos mais afetados pela catástrofe, pretendeu-se perceber os impactos registados, bem como as ações tomadas na posterioridade, de forma a mitigar os impactos e a reabilitar a atividade turística no pós-catástrofe, restabelecendo a normalidade do sistema turístico e aumentando a sua resiliência. Para tal, a metodologia consistiu na realização de entrevistas semiestruturadas a três grupos de interesse (político, empresarial e cultural), as quais permitiram concluir que houve, efetivamente, a implementação de um conjunto de medidas de apoio à recuperação das empresas turísticas afetadas, bem como o desenvolvimento de estratégias de comunicação com vista à qualificação e valorização do território após a catástrofe. No entanto, não se registou uma abordagem concertada entre os vários stakeholders, contemplando os interesses de todos, o que se constitui como um dos principais requisitos para um sistema turístico resiliente.
Mini-implantes extra-alveolares associados aos alinhadores no tratamento da má oclusão de Classe II
Authors: Almeida Marcio Rodrigues
Published: January 2021

INTRODUÇÃO: A associação de recursos auxiliares, como os mini-implantes, aos alinhadores permite amplificar o leque de opções terapêuticas, principalmente para casos complexos, nos quais a ancoragem é o ponto crítico. Além disso, tratar uma Classe II associando-se mini-implantes extra-alveolares aos alinhadores pode favorecer a obtenção de resultados mais precisos, mais previsíveis e mais rápidos, que dificilmente seriam alcançados com o uso isolado dos alinhadores. OBJETIVOS: o presente trabalho descreve a biomecânica do uso combinado de mini-implantes extra-alveolares e alinhadores num paciente com má oclusão de Classe II dentoalveolar. CONCLUSÃO: A associação de mini-implantes extra-alveolares aos alinhadores permite uma maior eficiência biomecânica na resolução da má oclusão de Classe II. Os mini-implantes extra-alveolares conectados por meio de um elástico corrente diretamente a botões colados aos dentes tornam-se uma excelente opção para reforço de ancoragem, sem a necessidade da cooperação do paciente com uso de elásticos intermaxilares de Classe II.
Avaliação tridimensional das vias aéreas superiores após o tratamento da má oclusão de Classe II com retrognatismo mandibular e SAHOS, associado ao uso de um dispositivo de monitoramento do tempo de uso
Authors: Bertoz André Pinheiro de Magalhães , Donine Ana Laura Modesto de Albuquerque , Demartine Mariana Santos , Weber Silke Anna Theresa
Published: January 2021

INTRODUÇÃO: A Síndrome da Apneia Obstrutiva do Sono (SAOS) é definida por episódios recorrentes de uma obstrução do ar nas vias aéreas durante o sono. Sua etiologia é multifatorial, podendo estar associada a fatores exógenos, patológicos ou anatômicos das vias aéreas superiores. A história clínica, além de exames complementares, como tomografia computadorizada e polissonografia (PSG), são determinantes para realização do diagnóstico definitivo. MÉTODOS: A terapêutica foi elaborada com o objetivo de aumentar dimensão transversa da maxila por meio da ERM, com o aumento da capacidade aérea nasal e um posterior avanço da mandíbula com uso do aparelho ortopédico funcional Bionator de Balters. No interior da estrutura acrílica do aparelho, foi programada a inserção do microsensor TheraMon para a análise do tempo de uso. RESULTADOS: Os resultados mostraram a melhora nos índices de apneia / hipopneia de 6,6/hora para 5,3/hora. O número de eventos respiratórios foi de 42 para 37, com diminuição de 16 episódios obstrutivos, 1 central e 13 mistos. No exame tomográfico, observou-se que o volume de ar presente foi de 15.275 para 73.832 mm3. CONCLUSÃO: A associação da expansão rápida da maxila com o avanço mandibular terapêutico como opção de tratamento da Classe II de Angle proporcionou o aumento volumétrico das vias aéreas, com consequente melhora no índice de apneia/hipopneia e na quantidade de eventos respiratórios do paciente. Observou-se, também, que o dispositivo de monitoramento de tempo de uso foi eficaz para uma melhora na cooperação do paciente durante o tratamento com o aparelho ortopédico removível.
Tratamento da má oclusão de Classe II com plano inclinado metálico associado ao expansor híbrido apoiado em mini-implantes
Authors: Suzuki Marcelo Keiji , André Cristiane Barros , Rino Neto José
Published: January 2021

INTRODUÇÃO: A deficiência mandibular está presente em mais de 70% dos casos de má oclusão de Classe II e, em muitos casos, é acompanhada de atresia maxilar, necessitando tanto de aparelhos de avanço mandibular quanto para a expansão da maxila. DESCRIÇÃO: O presente relato clínico descreve o tratamento de um paciente do sexo masculino, de 11 anos e 7 meses de idade, com as características descritas e pós-pico de crescimento, o qual foi tratado com um aparelho híbrido composto por um plano inclinado de resina acrílica recoberta com pista metálica, para avanço mandibular, e de expansor Hyrax apoiado em mini-implantes, para a expansão da sutura palatina de forma paralela. Em alguns meses, houve correção da relação de Classe II, por meio das alterações dentárias na inclinação dos incisivos, suavização da curva de Spee e aumento da distância intermolares na arcada superior. CONCLUSÃO: O aparelho híbrido foi eficiente na correção sagital, vertical e transversal, criando uma nova abordagem para intervenção precoce da má oclusão de Classe II.
Anquilose e reabsorção por substituição no esmalte em dentes não irrompidos
Authors: Consolaro Alberto , Hadaya Omar , Consolaro Renata Bianco , Miranda Dario A. Oliveira
Published: January 2021

INTRODUÇÃO: A reabsorção por substituição é mais lenta e tardia quando envolve o esmalte. OBJETIVO: O objetivo desse trabalho é ressaltar que o esmalte pode ser envolvido e fazer parte da anquilose alveolodentária e da reabsorção dentária por substituição, embora isso seja incomum no dia a dia clínico. Com base nos princípios da biopatologia óssea, não há necessidade biológica de se remover o dente envolvido, já que ele pode ser considerado uma estrutura óssea normal, podendo-se inclusive colocar na região um implante osseointegrável. CONCLUSÃO: Conclui-se que, na região onde se pode deixar um dente com anquilose alveolodentária e reabsorção por substituição, com ou sem esmalte envolvido, é fundamental que não haja possibilidade de contaminação microbiana dessa área, do mesmo modo que deve-se ter esse critério maior para planejar a colocação de implantes.
Implementasi Patient Safety di Pelayanan Anak Rumah Sakit Umum Haji Medan Tahun 2019
Authors: Simamora Verawaty Sari , Zulfendri Zulfendri , Simamora Roymond H , Asyura Nasution Puteri Citra Cinta
Published: January 2021

The complexity of diversity, relationships, variety and specialization can provide more opportunities for mistakes, one of which is in the children's hospital services. Based on patient safety incident report data at Rumah Sakit Umum Haji Medan in January 2018 to October 2018, it is known that child care is the unit with the highest number of patient safety incidents compared to other units at 37 incidents. Implementation of patient safety by officers in children's services is the main focus that must be considered its role to prevent the occurrence of patient safety incidents. This research is a qualitative research that aims to see the extent of the implementation of patient safety in child care at Rumah Sakit Umum Haji Medan from the description of the role of health workers involved in child care, namely the role of the head of a child's SMF, the role of a pediatrician, and the role of a child nurse. Data collection was carried out by in-depth interviews with 7 informants and through observation. The results showed the implementation of patient safety in children's services has not been running optimally. This is because not all health workers in child services, namely the head of the child's SMF, pediatricians and child nurses do their part in the patient safety system. The roles carried out are still focused on the standards of each profession. It is expected that routine socialization on the implementation of patient safety, the implementation of special meetings and discussions to study the patient safety system and the existence of patient safety drivers in child care designated as the person responsible for moving every officer to implement patient safety. Keywords: Implementation, Children's Services, Patient Safety
Lakat alatt – a járványügyi vészhelyzet korlátozó intézkedéseinek társadalmi hatásai
Authors: Borda Viktória
Published: January 2021

A Covid–19 vírus okozta világjárvány sok szempontból formálja a posztmodern kor társadalmait. Gyors terjedése és makroszintű hatásai nem pusztán az egészségügyi rendszerek működésére jelentenek komoly veszélyt, de a globális gazdaságban is a korábbi válságreakcióktól eltérő válaszokra várnak. Annak ellenére, hogy a 21. századra hatékonyabb diagnosztikai eszközökkel, orvosbiológiai válaszokkal, valamint nagyobb kapacitással és tudással rendelkezünk az egészségtudomány terén, mint a sokszor párhuzamba állított 1918-as spanyol nátha idején, farmakológiai beavatkozás hiányában, az elszigetelés, elszigetelődés mint járványügyi intézkedés hasonlónak tűnhet a múlt század eleji gyakorlathoz. A szociokönómiai környezet gyors és kényszerű változásai rávilágítanak a járvány egyenlőtlenségekre gyakorolt hatásaira a különböző dimenziókban.
A perinatális veszteséget kísérő kommunikáció jelentősége
Authors: Bornemisza Ágnes
Published: January 2021

A tanulmány felhívja a figyelmet a perinatális veszteséget kísérő értő intézményi kommunikáció fontosságára. A szerző szakirodalmi áttekintés és narratív interjúk segítségével mutatja be a kommunikáció torzulásainak várható hosszú távú hatásait. A perinatális veszteség során komplikált, elhúzódó gyászfolyamatra számíthatunk, ugyanakkor a támogatásra vonatkozó irányelvek teljesülését a Covid–19 kapcsán kialakuló válsághelyzet akadályozhatja.
ANÁLISE DO SISTEMA DE TRANSPORTE VEÍCULO LEVE SOBRE TRILHOS
Authors: De França Iara Da Silva , Da Silva Rayanne Sant'Ana
Published: January 2021

O presente artigo aborda uma breve análise do transporte público no estado do Rio de Janeiro. Através de um estudo relativo ao projeto veículo leve sobre trilho (VLT), demonstrando a importância de incluir um bom planejamento do transporte. O VLT é o que há de mais inovador nos sistemas de transporte e do espaço urbano, permitindo aos usuários maior integração com menor custo.
Změny v motorické výkonnosti chlapců ve věku 11-15 let mezi školními roky 1996/1997 – 2018/2019
Authors: Kuprová Klára , Ježková Martina , Kupr Jaroslav , Čapek Josef , Bittner Václav
Published: January 2021

The study evaluates changes in motor performance in older school-age boys at a primary school in Lomnice nad Popelkou. The development of motor performance is monitored in boys aged 11-15 years from non-sports classes on the basis of an informal test battery of six motor tests (run for 60 m, run for 1000 m, curl-up, long jump, triple jump from a place, pull-ups) in a period of twenty-two years (school years 1996/1997 – 2018/2019). A total of 1,863 boys of all ages participated in motor testing. The results indicate an unchanged to declining level of motor performance over the recorded time period for most of the tests used in all age groups.
Airway Management in the Emergency Department During Coronavirus Disease (COVID-19)
Authors: Pothiawala Sohil
Published: January 2021

Front-line health-care workers in the Emergency Department (ED) are at an increased risk of infection during the airway management of patients with known or suspected Emerging Viral Diseases (EVD) like Coronavirus Disease 2019 (COVID-19). The primary route for transmission of the virus from an infected patient to the ED staff is due to aerosolized droplets, and the transmission risk is high despite wearing adequate Personal Protective Equipment (PPE). There are limited evidence-based guidelines for airway management during these viral infections, especially with a focus on the principles of airway management in a busy, fast-paced ED. This article provides an overview of the principles of airway management in suspected or confirmed EVD patients, including COVID-19, particularly in the context of ED, and also considering strategies in resource limited setting. These principles should be adapted to suit your local department and hospital policy on airway management as well as national guidelines.
Correlation between Personal Hygiene, Household Hygiene, and Atopic Dermatitis in Elementary School Children in Indonesia
Authors: Bahari Muhammad Ikhfa Yusril , Paramita Deryne Anggia
Published: January 2021

Atopic dermatitis is a chronic inflammatory skin disease characterized by persistent itching and reddening of the skin. In general, infants and children are more susceptible to atopic dermatitis. Many factors are associated with atopic dermatitis, one of which is personal hygiene. Personal hygiene is a condition or practice to maintain or improve personal health by keeping the body and the environment clean. Personal hygiene can influence the surrounding environment, such as by influencing the household hygiene. The purpose of this study was to determine the correlation between personal hygiene, household hygiene, and atopic dermatitis incidence among children who attended Pertiwi Elementary School Medan. This was a cross-sectional study with correlational analysis designed conducted at Pertiwi Elementary School Medan from July to December 2019. Data were collected using a questionnaire and analyzed using the Chi-Square test with p = 0.05 considered significant. Results showed that 28 children (39.4%) had atopic dermatitis, with more girls affected than boys (n=19, 67.9% vs. n=9 32.1%). The overall household hygiene and cleanliness were good. There is a significant relationship between personal hygiene, household cleanliness, and the incidence of atopic dermatitis (p<0.05).
Analysis of risk factors for mortality among adult HIV infected patients on antiretroviral therapy: A case of hossana queen elleni mohammad memorial hospital, hossana, Ethiopia
Authors: Mekebo Gizachew , Handiso Adinew , Reddy O.Chandrasekhara
Published: January 2021

ven though the use of ART has brought a significant reduction in the mortality and morbidity of patients living with HIV/AIDS, a number of patients still die after the start of ART. This study was aimed at identifying factors associated with mortality among adult HIV infected patients who are on ART in HQEMM Hospital. The data for the study was obtained from HQEMM Hospital ART clinic. The HIV infected patients 15 years of age and who were under ART from March 2009 up to May 2015 were included in the study. Logistic regression model was employed to analyze the data to identify factors associated with Mortality of HIV infected patients. A total of 400 adult HIV infected patients who were taking ART were included in the study. Out of these patients, 18.75% of them died. The results obtained from logistic regression analysis showed that age, level of education, alcohol, baseline weight, TB status, and baseline CD4 count were significant factors of mortality of HIV infected patients taking ART in HQEMM Hospital. Patients with no education were more likely to die than those who attended at least primary school. Patients who drink alcohol were also more likely to die than those who do not. Health workers need to support those patients with no or little education by continuous awareness creation of taking care of themselves and knowing what factors facilitate death. Patients who drink alcohol need to be given advice to reduce excessive drinking.
Pedagogical Inteaction in the University Environment
Authors: Todorova-Koleva Mariela
Published: January 2021

The article represents the main points of the pedagogical interaction between first year university students, and the lecturers in the university environment. An inquiry was conducted among 45 students from the Faculty of Education in University of Veliko Tarnovo „St. Cyril and St. Methodius According to the students, the basis of good and effective interaction is mutual respect, good communication and communication skills, the presence of feedback and a process involving both the lecturers and the student.
Influence of microbiome on a woman’s reproductive function
Authors:   СNP of the Lviv Regional Council “Lviv Regional Center for Reproductive Health”, Malachynska M. ,   Danylo Halytskyi Lviv National Medical University, Veresniuk N. ,   СNP of the Lviv Regional Council “Lviv Regional Center for Reproductive Health”,   Danylo Halytskyi Lviv National Medical University
Published: January 2021

The interplay between the microbiome and the reproductive organ system is a complex functioning mechanism that continues to be the subject of much contemporary research. The microbiome of the reproductive sphere plays an important role in the onset and delivery of pregnancy, the frequency of live births, influences the result of assisted reproductive technologies and the like. This study substantiates the feasibility of using a multi-strain probiotic in the complex treatment of infertile patients. The objective: to investigate the efficacy of administering a multi-strain probiotic to patients with infertility. Materials and methods. Under our observation, from 2017 to 2020, there were 94 patients with infertility. The age of women ranged from 22 to 35 years. All participants in the main group, 64 patients, received a multi-strain probiotic, which included 5 strains of bacteria, 1 capsule once a day during meals, for 1 month before planning the pregnancy. The comparison group consisted of 30 women with infertility who did not take any probiotics. Results. Analyzing the results of vaginal biocenosis examination in the examined women, normocenosis was established in 33 (35.1%) patients. Bacterial vaginosis occurred in almost every fourth patient (23.4%), every third woman (30.9%) had an intermediate type of smear, and 10.6% of patients were diagnosed with nonspecific colpitis. Among the patients in the main group, pregnancy occurred in 21 women, accounting for 32.8%. At the same time, 4 patients (13.3%) became pregnant in the comparison group, one of whom was after intrauterine insemination and another was due to IVF (p<0.5). No women of the main group were observed side effects of the drug. Conclusion. The incidence of pregnancy in infertile patients who used a multisystem probiotic at the pre-gravid stage was 32.8%. The use of a multi-strain probiotic increases the incidence of implantation in infertile patients (p = 0.0464), however, more research is needed on this topic. Keywords: microbiome, lactobacillus, infertility, pregnancy.
Integrated approach to therapy and prevention of recurrences bacterial vaginosis in women of reproductive age with overweight and obesity
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Kondratiuk V.K. ,   SI «Institute of pediatrics, obstetrics and ginecology named academic Elena. M. Lukyanova NAMS of Ukraine», Hasparian K.A. ,   SI «Institute of pediatrics, obstetrics and ginecology named academic Elena. M. Lukyanova NAMS of Ukraine», Kondratiuk K.O. ,   Bogomolets National Medical University, Kyiv, Dzіs N.P. ,   National Pirogov Memorial Medical University, Vinnytsia, Ukraine, Koblosh N.D. ,   SI «Institute of pediatrics, obstetrics and ginecology named academic Elena. M. Lukyanova NAMS of Ukraine»
Published: January 2021

The aim of the study was to evaluate the clinical efficacy of an integrated approach to therapy and prevention of relapse of bacterial vaginosis in women of reproductive age with overweight and obesity. We examined 60 women of reproductive age (19–39 years) with overweight and obesity (BMI+30±4.2) and a verified diagnosis of recurrent bacterial vaginosis (real-time PCR, diagnostic system Femoflor–16). The effectiveness of treatment of bacterial vaginosis in overweight and obese women was 94.0% due to the rapid elimination of the pathogen by a single dose of 2 g of the drug group 5-nitroimidazoles Secnidox and macrolide 16-membered antibiotic with bactericidal mechanism Doramycin (World Medicine, United Kingdom). Combination prolonged therapy with the multi-strain probiotic Brevelac and the natural drug Reitoil increased the remission period of bacterial vaginosis to 6 months in 91.0% of this group of patients. Keywords: bacterial vaginosis, overweight, obesity, therapy, remission.
Proportion of TLR-9 Gene Polymorphisms at rs352139 (G1174A) in HIV/AIDS Patients in West Java, Indonesia
Authors: Yonathan Yehezkiel , Sahiratmadja Edhyana , Indrati Agnes Rengga
Published: January 2021

Background: Human immunodeficiency virus (HIV) infection is the main cause of the immunodeficiency syndrome (AIDS). TLR-9 gene encodes a toll-like receptor-9 that plays a key role in innate immunity. This study aimed to describe the proportion of TLR-9 polymorphisms at rs352139 in patients with human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) in Bandung, West Java, Indonesia. Methods: This was a descriptive study involving a total of 96 patients with HIV/AIDS treated in a tertiary hospital in Bandung, West Java, Indonesia in 2013. TLR-9 gene polymorphisms at rs 352139 were examined using a mass screening platform and the genotypes proportion was presented in percentage and compared with other populations. Results: The average age of the HIV/AIDS patients recruited was 30 years (SD+6.1) and the baseline mean of CD4+ count was 318.02 mm3 (Normal was 1,500 mm3) (SD+273.1). The proportion of polymorphisms at rs352139or G1174A presented a wild type genotype GG (42.7%), GA (44.9%), and AA (12.4%), resulting in a total proportion nucleotide change of 57.3%. Conclusion: A total proportion of nucleotide change or polymorphisms is higher than the wild type. A further cohort study is of great interest to associate the rs352139 polymorphisms with a decrease in CD4+cells in HIV/AIDS patients, confirming a rapid disease progression.
Talk Shows and Leaflets Improve Senior High School Student Knowledge of Chronic Kidney Diseases
Authors: Imelda Laurensia , Supriyadi Rudi , Zuhairini Yenni
Published: January 2021

Background: The increase of chronic kidney disease (CKD) incidence and its related costs in developing countries have urged all levels of society prevent this disease. Prevention can be effectively done when someone has good knowledge about the disease. This study aimed to observe the change in knowledge about CKD before and after education sessions in the form of talk shows as well as through the leaflet media among senior high school students. Methods: This was a cross-sectional observational quantitative study on 71 first-grade students participated in World Kidney Day 2019 event. The questionnaire was distributed before and after the education program and data collected were analyzed using the Wilcoxon-signed rank test and Mann-Whitney test to explore changes in the level of knowledge based on the characteristics of the subjects. Results: The median level of student knowledge before education was 76% (16-96%), which increased to 92% (28-100%) after education (p<0.001). No significant correlation was observed between knowledge about CKD and gender (p=0.486), family history of CKD (p=0.281), and health workers as parents (p=0.543). Conclusion: There is a significant improvement in knowledge of CKD before and after an education session through talk shows and leaflets among senior high school students. Health educations need to be regularly given to young adolescents using different approaches to increase their knowledge about various topics.
Preservation in Paraffin Oil: Alternative for Fungi Preservation in Simple Laboratory Concept
Authors: Surja Sem Samuel , Sally Gabi Vania , Hartoyo Favian Sergius Ruby , Kurniawan Sandy Vitria , Budiman Yanto
Published: January 2021

Background: A good collection of fungi culture can be maintained with good preservation methods. With appropriate methods, preservation can be performed in low-budget laboratories, such as with periodic subculture and preservation in either sterile water or in paraffin oil. The aim of this study was to assess the viability, morphology, contamination, and antifungal susceptibility profile of fungi preserved in sterile water or paraffin oil compared to a periodic subculture. Methods: This study was an experimental study using Aspergillus sp., Trichophyton mentagrophytes and Candida albicans. The fungi were preserved by a periodic subculture or in sterile water or in paraffin oil for six months. A comparison of viability, morphology, contamination, and antifungal susceptibility profile between methods were made before and after six months of study. Results: The viability of all the fungi was maintained in both periodic subculture and preservation with paraffin oil. However, the T. mentagrophytes was not viable in preservation using sterile water. All methods could maintain the morphology without contamination. There were reductions in the inhibition zone against antifungal drug in preservation with sterile water and paraffin oil. Conclusion: Preservation in paraffin oil is superior to preservation in sterile water in terms of maintaining fungal viability. This method is suitable for the use in a simple laboratory, albeit considerations should be given to the reduction of inhibition zone.
Transfusion Reactions in Pediatric Cancer Patients
Authors: Pranata Cakra Jati , Suryawan Nur , Prihatni Delita
Published: January 2021

Background: Transfusion is an essential component of supportive management for cancer patients with anemia and thrombocytopenia. It is generally safe; however, it has several risks and complications including those caused by transfusion reactions. This study aimed to describe transfusion reactions in pediatric cancer patients in a tertiary hospital in Indonesia. Methods: This was a descriptive cross-sectional study with a total sampling method. A prospective analysis was performed on episodes of blood transfusion in pediatric patients aged younger than 18 years old with cancer and were hospitalized at the Department of Child Health of the hospital from July to August 2019. After the consent of the parents, the patients were interviewed for various transfusion reactions. Data collected were presented using tables and charts. Results: Leukemia was the most frequent cancer in children cancer patients who need transfusion. Out of 42 children included, 155 episodes of transfusion were observed with 22 episodes showed transfusion reactions (14.2%). The most frequent manifestations were pruritus (31.8%), followed by combination of pruritus and erythema (27.4%) and fever (13.6%). These reactions appeared mostly in 1 to 2 hours (27.2%), with most were mild reactions (59.1%). Conclusion: Transfusion reactions mostly occurred among pediatric patients with cancer in the acute phase with clinical manifestation of allergic reactions, predominantly mild. Early identification of these reactions would result in better treatment and prevention for recurrence of transfusion reactions.