bluuebunny/crossref_metadata_2025 huggingface dataset:
NEW PERSPECTIVES OF PERSONALIZED THERAPY OF CHRONIC HEPATITIS C
Authors: Sapronov G. V. , Nikolaeva L. I.
Published: April 2021

The aim of this review - to analyze the possibilities of traditional therapy and opening new perspectives and approaches to personalized theraру of patients with chronic viral hepatitis C. There are considered the viral and patien tfactors that have an mpact on the efficacy of theтру with interferon-a2 and ribavirin. There are presented data on the molecular mechanism of action of these drugs preparations. There are considered new antiviral drugs (protease inhibitors) and pharmacological agents being under development and targeted to viral polymerase andprotein NS5A.
Diseases caused by arthropods-moth larva in clitoris, tungiasis, cutaneous and intestinal myiasis in Russian travelers: report of eight cases and review the literature
Authors: Bronshteyn A. M , Malyshev N. A , Kochergin N. G , Jarov S. N , Vikhrev N. E
Published: April 2021

Diseases caused by several species of arthropods are rare diseases in Europe. Very few cases of these diseases have been reported in the literature. It is widespread in the tropics and subtropics of Africa and the Americas, and occurs with significantly less frequency in most other areas of the world. They are defined by the development of parasitic, mostly tropical maggots and sand fleas in the human body. The infestation of body tissues by the larvae of flies, sand fleas and moth caterpillars, occurs infrequently in Russian tourists who return from areas where certain species are endemic. As travel to endemic regions becomes more common, physicians are increasingly confronted with cases of diseases caused by arthropods. They may be unfamiliar with this parasitic infection; thus, misdiagnosis and inappropriate treatment regimens are not infrequent. Greater awareness about clinical symptoms and relevant exposure histories would improve the expediency and efficacy of treatment for patients with diseases caused by arthropods. Cutaneous myiasis is a worthy differential diagnosis in patients presenting with furunculoid skin lesions after traveling to endemic areas. Treatment consists in the elimination of the larvae in the infected tissue and disinfection of the wound
RESPIRATORY AND NERVOUS SYSTEMS CENTRAL NERVOUS SYSTEM LESIONS DUE TO STREPTOCOCCUS PNEUMONIAE INFECTION IN HIV-POSITIVE PATIENTS
Authors: Nikolenko V. V. , Vorobiova N. N. , Naumova L. M. , Solodnikova E. A , Bondarenko V. V. , Abrosimova O. V. , Nagaenko A. V. , Golikova E. V. , Minikeeva M. R.
Published: April 2021

Currently registration of community-acquired pneumonia and purulent meningitis caused by S. rneumoniae patients in HIV-positive patientsis is not carried out, there is absent the description of the clinical symptom complex. In this regard, the purpose of the work was the detection of the features of the course of pneumococcal infection with the lesion of the respiratory and nervous systems in HIV infection. A clinical and laboratory examination of 110 HIV-positive patients with community-acquired bacterialpneumonias andpurulent meningitises was performed. Community-acquiredpneumonia fulminates with the massive damage of the lung tissue, the presence ofpleural effusion, the early development of respiratory failure, decreased SaO2
A CASE OF Q FEVER IN NON-ENDEMIC AREAS
Authors: Nafeev A. A. , Bezik V. V.
Published: April 2021

Coxiellosis (Q-fever) is a systemic natural focal zooanthroponosis disease, which has a very wide geographical area. A variety of clinical manifestations and the absence of pathognomonic signs of illness forces to use for making a definite diagnosis complex of techniques including epizootological, epidemiological data, clinical manifestations, and certainly the results of several serological tests designed to detect antibodies to Coxiella burnetii. There is presented a description of an acute case of Q - fever in a child in the subject, characterized as trouble-free of Coxiellosis from 70-ies of the last century.
CASE OF SEVERE DENGUE FEVER DENGUE ASSOCIATED WITH WILSON-KONOVALOV DISEASE
Authors: Saifullin M. A. , Kadyshev V A. , Larichev V F. , Andreytseva O. I. , Boitsov P. V , Butenko A. M. , Malyshev N. A.
Published: April 2021

A case of severe dengue fever in a patient with Wilson-Konovalov disease occurred after a trip to Thailand is described. Difficulties of diagnostics of dengue fever at an out-patient and hospital stage are noted. The possible severe course of infectious diseases associated with chronic somatic pathology is discussed.
OUTBREAK OF ANTHRAX IN THE OMSK REGION IN 2010
Authors: Safonov A. D. , Kriga A. S. , Pnevskiy Y. A
Published: April 2021

There is given a description of outbreaks of anthrax in humans and animals in the Omsk region in 20J0. There are presented epidemiological, epizootological, clinical features and outcomes of the disease, the methods used for laboratory confirmation of the diagnosis, treatment principles.
Morphological changes in the liver in patients with pulmonary tuberculosis and HIV infection on a background of chronic hepatitis "C"
Authors: Babaeva I. Yu , Avdeeva M. G , Gedymin L. E , Chumachenko G. V , Adamchik N. Yu
Published: April 2021

The purpose of the study. The establishment of the features of the course and morphological manifestations of tissue responses in liver in chronic hepatitis "C" in patients with disseminated pulmonary tuberculosis on a background of HIV infection. Materials and methods. The results of the pathomorphological studies carried out on autopsy material of 11 observations of patients with diagnoses of TB associated with HIV and hepatitis "C" are reported. The comparison group was consisted of 3 patients with HIV and hepatitis "C" and one patient with generalized hematogenous tuberculosis and chronic hepatitis "C". The results of the study. Changes in the liver in the combination of TB with HIV and hepatitis "C" have a different intensity, depending on the stages of combined pathology. At the early stages of HIV infection (2B), in presence of localized tuberculosis, there is possible rapid progression of hepatitis "C" into cirrhosis of liver, which becomes the main cause of death. For the later stages of HIV infection ( 4B-5 ) there is typical the development of generalized forms of tuberculosis with the appearance of confluent caseous necrotic lesions in all organs and tissues. In these cases in the structure of the liver there are determined severe circulatory disorders, pronounced dystrophic and necrotic changes in the parenchyma, inflammatory responses caused both generalized tuberculosis and hepatitis "C". In generalization of disseminated lungs tuberculosis in the liver, monocytoid response and lymphopenia are established to take place, and at the late stage (4B - 5) stage of HIV infection there is noted aplasia of elements of lymphoid series and diffuse plazmatization. The correlation between the severity of the process and the intensity of exudative changes was revealed. Conclusion: The liver disorders in patients with HIV infection, tuberculosis and hepatitis "C" may determinative in the outcome of the disease and should be considered when choosing a scheme of etiotropic and pathogenetic treatment and the staging of therapy.
Clinical and epidemiological characteristics of tick-borne borreliosis in the Krasnodar Krai
Authors: Avdeeva M. G. , Moshkova D. Yu. , Blazhnyaya L. P. , Gorodin V. N. , Zotov S. V , Vanyukov A. A , Kovalevskaya O. L
Published: April 2021

The purpose of the study the improvement of early diagnostics of Lyme disease on the based of clinical and epidemiological analysis of the main clinical forms of the acute course of the disease in new natural foci in the Krasnodar Krai. Patients and methods. There was analyzed the clinical course of disease and epidemiological data for 207 patients in the early period of acute course of Lyme disease within the period from 2004 to 2013. Results. In the territory of the Krasnodar Krai and the Republic of Adygea there has formed a set of foci of tick-borne borreliosis (TB), i.e. Lyme disease (LD). The infection of cases is observed not only in the natural foci of disease, but also within the city limits. The disease is registered mainly in the erythematous form (74% of patients), non-erythematous form accounts for 26%. The average age of patients was 41,1±1,83, years, males 38%, females 62%. In the non-erythematous form initial clinical symptoms are recorded in average in 11,6 ± 2,20 days after tick suction; in the erythematous form in 6,4 ± 0,70 days ( p
PROSPECTS OF THE USE "STIMFORTE" IN CHRONIC HEPATITIS B
Authors: Pogorelskaya L. V , Khlopova I. N , Grigoryan S. S , Tryakina I. P , Rick N. A , Maldov D. G
Published: April 2021

Despite the fact that over the last few years downward trend in the incidence of acute forms of viral hepatitis B continues, the incidence of chronic hepatitis B (CHV) has increased by 2.5 times since 1998. To date, there are a sufficient number of antiviral drugs, but their use is associated with a set of contraindications, as well as the development of resistance. In this study there was performed an evaluation of a new national drug " Stimforte " in patients with chronic viral hepatitis B (CVHB - DNA positive, HBsAg - positive) at the stage of exacerbation. In the study there were included 28 patients with chronic hepatitis B (HBsAg positive), at different grades of activity, at a stage of viral replication. The diagnosis of chronic hepatitis B was made on the presence in a history acute viral hepatitis for more than 1 year, complaints, hepatolienal, astenovegetative, cytolytic syndromes, the presence of DNA-HBV, anti-HBcore IgM, HBsAg. After 1 course of treatment with " Stimforte " the well-being of patients has improved: in 30% of patients asthenic- vegetative syndrome had disappeared, weakness, fatigue and dyspeptic symptoms were decreased. The use of "Stimforte" in chronic hepatitis B with positive HBsAg at the stage of exacerbation contributed to a more rapid normalization of such indices as ALT, AST, compared with those in the control group. Long-term biochemical and virological remission was achieved in 40 %. It is established that during the treatment the viral load was reduced progressively until the undetectable or low level of HBV DNA and anti-HBc IgM disappeared. In only one case an allergic reaction was observed, which has not hindered to perform a complete course of treatment. No other side effects were detected. The inclusion of the drug "Stimforte" in the complex therapy of patients with exacerbation of chronic hepatitis B reduces the time of recovery of immune status and functional activity of IFN system and contributes to reduction of the viral load or elimination of the virus.
RISK OF APPEARANCE OF LIVER CIRRHOSES AND THE ONSET OF LETHAL OUTCOMES IN VIRAL HEPATITISES OF MIXED ETIOLOGY
Authors: Isaeva N. V. , Pavroz K. A. , Galbraykh R. B. , Tryasolobova M. A.
Published: April 2021

Viral hepatitises of mixed etiology are referred to the poorly studied area of hepatology. In mixt hepatitises chronogenic potential is 3.7 times, the probability of appearance of liver cirrhosis - 10.0 - 18.0 times and the onset of lethal outcome - 25.0 times more than in mono-hepatitises
Clinical and epidemiological aspects of the incidence of nonpolio enteroviral infections in Primorsky Krai
Authors: Kolpakov S. L. , Popov A. F. , Mirgorodskaya N. V.
Published: April 2021

There are considered problems of epidemiology and clinical presentation of enteroviral infections in the territory of Primorsky Krai. Among the hospitalized adult patients during the period from 2006 to 2012 persons aged from 18 to 39 years (49,3%) prevailed. The main clinicalforms of enteroviral infection (EVI) are a "minor" illness (55.6 %) and serous meningitis (21.7 %). In the study of a series of cytokines the differences in patients with the "minor" illness and serous viral meningitis have been identified. From 2009 to 2012 the incidence of EVI has a sporadic seasonal character (previously there was epidemic seasonal incidence). Adults are mainly affected. The epidemic process is formed owing to corporate and school-university types, with a dominated contact-community-acquired pathway of transmission. The dramatic shift in the nature of EVI rate in recent years, likely due to the exchange of the leading modes of transmission pathway, nutritional, which determined the carrying non-typical for the Primorsky Krai pathogen variants (ECHO - 30), by the contact-community-acquired pathway of transmission.
Phylogenetic analysis in epidemiological investigations of cases of HIV infection
Authors: Sandyreva T. P. , Gerasimova N. A. , Lopatukhin N. A. , Kireev N. A. , Kuevda N. A. , Shipulin N. A. , Podymova N. A.
Published: April 2021

Phylogenetic analysis of nucleotide sequences of HIV-1 variants was applied in epidemiological investigation of the case of the group incidence of HIV infection for identification of the genetic relatedness and verification of clinical and epidemiological findings. The article also raises issues the solution of which will improve the quality of the performance of such investigations.
PROSPECTS OF THE USE OF PHOSPHAZIDE IN THE SCHEDULES OF ANTIRETROVIRAL THERAPY FOR HIV INFECTION
Authors: Vorobiova N. N. , Ivanova E. S.
Published: April 2021

The aim of the study was to evaluate the effectiveness of triple antiretroviral theтру, including domestic product Phosphazide in 18 HIV-infected patients during 48 weeks. There was determined the dynamics of the clinical manifestations of the disease, the parameters of viral load and CD4 lymphocytes before antiretroviral therapy (ART), and 4, 12, 24, 36 and 48 weeks after its use. The study showed high virological and sufficient immunologic efficacy of this schedule.
On the question of pathogenesis of in chronic HCV-infection
Authors: Avdeeva M. G. , Lysenko I. V.
Published: April 2021

In a review of the literature there are considered the problems of hematopoiesis in HCV-infection and discussed the different mechanisms of anemia. On the basis of the analysis of current evidence it was shown that anemia in chronic hepatitis C may have hyporegenerative character and be associated with myelosuppressive effect of viral infection (directly or indirectly through a change in cytokine profile), it has features of the so-called anemia of chronic diseases, or be regenerative as a consequence of chronic blood loss, immune and non-immune hemolysis, microangiopathies, hypersplenism. In the formation of anemia there are important factors: the development of iron deficiency and/or vitamin B I2 deficiency, the effects of alcohol, and hormonal perturbations. The mactocytes presence in the peripheral blood is shown to be one of the characteristics of hematopoiesis during HCV-infection.
A life devoted to the fight against the plague and tularemia (on the occasion of the 130th anniversary of the birth of N. A. Gayskiy)
Authors: Knopov M. Sh. , Taranukha V. K.
Published: April 2021

In the article there is presented the life and the creative work way of a prominent national epidemiologist, a microbiologist and immunologist, a talented organizer of medical science, USSR State Prize winner, Nikolay Akimovich Gayskiy.
Perinatal viral hepatitis C and performance capabilities for its therapy
Authors: Goryacheva L. G , Rogozina N. V , Greshnyakova V. A , Ivanova V. V
Published: April 2021

The aim of the study: to establish the rate of the vertical transmission of HCV infection and justify the usefulness of the drug a-IFN2b (Viferon®) in children with perinatal infection with hepatitis C virus (HCV) at the early stages of the disease. There were examined 465 children aged 2.5 months to 3 years old (at the time of the enrollment in the study), born to mothers with HCV infection and the frequency of transmission from mother to child was established to be is 7.1% (33 cases). In 54.5% the genotype 1b was recorded, in 3% - 1a, and in 6.0 % - 2 genotype. Viferon® drug in doses of 3х10 6IU/m 2 was introduced to 17 infants aged from 3 to 12 months (duration of the course: 6 months in cases with 3, 2 genotype and 12 months - in patients with genotype 1). The efficacy of therapy was 58.8 % (RNA HCV (-) 10 cases. In prescription the drug to children under 6 months the efficacy was 62.5%, under 6-12 months - 44.4%. In the control group (16patients) spontaneous viral clearance was established to be in 18.7% of cases. The medication did not cause adverse effects and was well tolerated by children. In none out of the 17 children treated with the drug Viferon®, we have not reported adverse events (clinical symptoms, abnormalities in the hemogram and biochemical indices). The obtained data confirm the expediency of the early use of antiviral drug Viferon® in the treatment of children with perinatal HCV. Nо significant difference in the efficacy of therapy in different genotypes of the virus was identified. Virtually in all children (9 out of 10 children) responded to Viferon® therapy, there was noted Sustained Viral Response
Molecular genetic factors of pathogenicity of influenza A virus (H1N1) pdm09
Authors: Tsvetkov V. V , Deeva E. G , Danilenko D. M , Sologub T. V , Tikhonova E. P
Published: April 2021

Unlike influenza epidemics which affect the population almost yearly, pandemics occur much less frequently, but have more severe medical and social consequences. The investigation of the nature of the course of all modern epidemics and pandemics are acquiring the particular rationale. Pandemic influenza A (H1N1) 2009 was caused by the virus of the mixed (triple) origin. In Russia, the first three cases of disease have been identified in Moscow from 21 to 10 June 2009. In the Far East - 2-2,5 months later compared to the European part of Russia. However, the epidemic of influenza in Russia caused by influenza virus A (H1N1) pdm09, began and developed more rapidly just in the Far East. The highest morbidity rate (10,2-10,3 per 100 people) was registered in the cities of the Far Eastern and Siberian regions. The phylogenetic analysis allowed to reveal the origin of the triple reassortant virus A (H1N1)pdm09 out of H1N1, H1N2, H3N2 avian/porcine/human virus. The performed analysis of functional domains of proteins of the influenza virus A (H1N1) pdm09 showed that modern pandemic influenza viruses have several principal genetic defects, the totality of which permits to rank them to moderately pathogenic viruses. High risk of the severe course of influenza and occurrence of complications was noted in three groups ofpatients: pregnant women, especially in the 3 trimester ofpregnancy, children under 2 years of age and patients with concomitant chronic respiratory and cardiovascular systems, as well as patients with endocrine disorders and obesity.
Vaccine therapy of chronic tick-borne encephalitis
Authors: Pogodina V. V , Shcherbinina M. S , Bochkova N. G , Bezrukova E. G , Naumov E. I , Snigur T. A , Levina L. S
Published: April 2021

Chronic tick-borne encephalitis (CTBE) is a severe form of the disease, leading to permanent disability and death. Most cases of CTBE caused Siberian subtype of a virus of tick-borne encephalitis virus (TBEV), dominant in the Russian Federation. The pathogenesis of CTBE associated with persistence of TBEV in the central nervous system and the organs of the immune system. Specific vaccine therapy with using of inactivated full-virion vaccines prevents immunosuppression, leading to activation of persisting tick-borne encephalitis. The article describes various schemes of CTBE vaccinotherapy. Dynamics of humoral immunity in CTBE caused by Siberian subtype of TBEV. In the early stages and during remission antibodies against this subtype are detected. Vaccine therapy increases the level of immunity to all subtypes of TBEV, slowing the progression of the disease. In seronegative status of the patient vaccine therapy is not effective: from the central nervous system of a deceased patient severe strain «Zausaev» was isolated. Mechanisms of high immunity after 30-32 years after vaccine therapy and advantages of vaccine therapy compared with treatment of CTBE using specific immunoglobulin are discussed.
New data on the pathogenicity of genotype of Rickettsia sibirica subspecies BJ-90
Authors: Rudakov N. V , Shpynov S. N , Reshetnikova T. A , Penevskaya N. A , Abramova N. V , Kumpan L. V
Published: April 2021

New data about pathogenicity of Rickettsia sibirica subspecies BJ-90 were obtained. Rickettsial strains of this subspecies from the Primorye region were pathogenic for guinea pigs and chick embryos, multiplied in cell cultures Vero E6. Antibodies against Rickettsia sibirica subspecies BJ-90 in ELISA were detected in the Omsk region in patients with clinical manifestations after bites of ticks. Analysis of available data indicates to the likely pathogenicity of this genotype for human. Due to the low cross reactivity of R. sibirica subsp. BJ-90 and R. sibirica subsp. sibirica in combined foci serological diagnosis of tick-borne rickettsioses in ELISA should be carried out with antigens of both subspecies of Rickettsia sibirica.
Clinical and microbiological comparisons in whooping cough in children under modern conditions
Authors: Popova O. P , Borisova O. Yu , Petrova M. S , Gracheva N. M , Abramova E. N , Pimenova A. S , Gadua N. T
Published: April 2021

Comparative researches have been performing since 1990th years, and were devoted to the study of the interrelationship ofserotype landscape of circulating B.pertussis strains with the severity of clinical course of whooping cough. The researches performed in the 2000th years, showed that in patients with identified strains of B.pertussis serotype 1.0.3, the proportion of children with heavy forms of an illness, in comparison with the 1990thyears considerably increased, reaching 43,2±5,0%, against 18,6±3,6. The analysis of the dependence of clinical picture manifestations of whooping cough from the genotypes of B.pertussis has been performed in 83 patients, among them children at the age up to 1 year (77,1±4,6% ofpatients) prevailed. Genotyping of strains of B.pertussis was carried out with the help of two schemes of multilocus antigen sequence typing (MAST1 and MAST2). As a result of the study of the influence of genotypic properties of B.pertussis strains on clinical manifestations of an infection the most severe course of disease was established to be caused by strains of B.pertussis of genotypes 932 MAST1, 319 MAST2 and 329 MAST2. In work there is presented the careful analysis of symptomatology of the prodromal period and the spasmodic cough, performed in 2 groups of children with the severe and moderate form ofwhooping cough. In whooping cough caused by B.pertussis strains of genotypes 932 MAST1, 319 MAST2 and 329 MAST2, there are most pronounced symptoms determining the severity ofthe course of infection.
Characteristics of antibiotic resistant strains of Vibrio cholerae carrying SXT type integrative conjugative elements
Authors: Podshivalova M. V , Kuzyutina Yu. A , Zakharova I. B , Lopasteyskaya Ya. A , Viktorov D. V
Published: April 2021

In the paper there is presented a characteristics of antibiotic-resistant strains of Vibrio cholerae, isolated in the Volgograd region during the period of 1980-2000. There were studied cultural and morphological properties of the isolates, their biochemical activity, resistance to antibiotics of different classes, there was performed the detection of virulence genes and sequences of transmissible SXT-element. There was demonstrated the presence of different types of SXT in the content of the genome of the examined strains - SXT MO10 element with cluster of the antibiotic resistance gene sulII-strB-dfr18, SXT ET element carrying the sequences sulII dfrA1, and not having a resistance gene to aminoglycosides strB, and SXT S element with deleted cluster of antibiotic resistance genes.
Epidemiological characteristics of infections associated with delivery of health care in surgical departments
Authors: Orlova O. A , Akimkin V. G , Chistova A. V , Efremova N. P
Published: April 2021

For the present time the problem ofprevention and treatment of infections associated with the delivery of health care (IAHC) in surgical departments remains to be the one of the most important worldwide. IAHC aggravate the general state ofpatients and increase the duration of hospital stay. Aim: to perform the analysis of IAHC in surgical departments with bearing in mind their nosological forms and etiological features. At the base of the analysis there was taken an analysis of4504 cases of IAHC, recorded in surgical departments in Chelyabinsk for 9 years. In the structure of IAHC the prevalent place was occupied by infections in the area of surgical interventions and respiratory tract infections - 44.5% and 43.3%, respectively. There was noted the change in the structure of IAHC: the number of recorded infections in surgery tends to decrease (from 66.4% in 2004 to 31.1% in 2012), while the number of recorded bloodstream infections and urinary tract infections is increasing annually (from 0 in 2004 to 8.6% and 7.0% respectively in 2012). In the etiological interpretation of IAHC the plenty large enough part (from 5.8% of infections of the urinary system and 19.7% of infections in the surgical intervention) remains to be unexplained, that indicates to the defects of the samplings of the biological material and precludes to perform the adequate etiotropic therapy. There was shown the needfor the realization of the differentiated approach to the development of the measuresfor the prevention of IAHC.
Modern aspects of epidemiology of ticks transmitted infections
Authors: Konkova-Reydman A. B , Ter-Bagdasaryan L. V
Published: April 2021

Modern literature data have changed our imaginations about the etiological "landscape" of the diseases arising after the suction biting of ticks. The possibility of transmitting mixt-infections by ticks has become an important scientific and practical problem. Ticks can be infected by the all 7 found pathogens (TBE virus, 3 species of Borrelia, Ehrlichia, Anaplasma, Babesia). Among ticks with the modified morphology monoinfected individuals occur 1.3 times, biinfected - 1.5 times more frequently, and the cases of triple infection appear twice more often than among normal cases. There were formed new ideas about genotypic and phenotypic heterogeneity of natural populations of tick-borne virus, there is discussed the heterogeneity of the genome and the pathogenic properties of the TBE virus. There was performed the analysis of literature data about the multifacetedness of the genetic polymorphism typical for the genus Borrelia in total, observed phenomena of the discrepancy of the spectrum of genospecies of Borrelia in natural foci and in biological materials from patients, complex antagonistic tolerant or symbiotic interactions between various intracellular and extracellular pathogens carried by ticks, in the vector's body, reservoir hosts and macroorganism.
Polymorphism of interleukin 28b gene as the monitoring parameter of the epidemiological surveillance system for Hepatitis C
Authors: Kuzin S. N , Kudryavtseva E. N , Korabelnikova M. I , Horuzhenko A. S , Glinenko V. M , Bogomolov P. O , Mantrov A. I , Dubodelov D. V , Polonsky V. O , Lavrov V. F , Semenenko T. A
Published: April 2021

The ratio of gene IL28В genotypes (rs12979860 C>T, rs8099917 T>G) were studied in patients with chronic hepatitis C (CHC) and in the comparison group (patients with chronic hepatitis B) in the Moscow region. Genotypes СС (rs12979860) and ТТ (rs8099917), which are the predictors ofsustained virological response to the antiviral therapy, were found in 26% and 55% of CHC patients and in 45% and 71% patients in the comparison group, respectively. The differences in these groups are statistically significant..There was reveled an absence of differences in the frequency of detection of gene IL28В genotypes in CHC patients, in dependence on the HCV genotype. There was advanced an opinion that that the inclusion of Simple Nucleotide Polymorphism in the gene IL28B, as another parameter to be monitored, will increase effectiveness of the monitoring. The monitoring of Single Nucleotide Polymorphism (SNP) in IL28B gene in the system of the epidemiological surveillance for hepatitis C, as another parameter to be monitored will allow to increase its efficacy. There was determined the place of the monitoring for Single Nucleotide Polymorphism (SNP) in IL28B gene in the system of the epidemiological surveillance for hepatitis C an the parameters which extend the information base required for the formation of an epidemiological forecast.
Clinical masks of pleuropulmonary dirofilariasis, a rare clinical presentation of dirofilariasis in Russia: a report of four cases and literature review
Authors: Bronshteyn A. M , Malyshev N. A , Fedianina L. V , Frolova A. A , Davydova I. V
Published: April 2021

There arc described four cases of infection of the lungs and pleura with Dirofilaria in patients infected in the Moscow region and Moscow, with clinical manifestations of recurrent exudative pleurisy, tumor-like formations in the pleura and the lungs. Non-specific clinical symptoms and clinical simulation of common known diseases render difficult the clinical and instrumental diagnosis of pleuropulmonary dirofilariasis. Currently, the best method of diagnosis and treatment of heartworm lungs and pleura is Videothoracoscopy. There are analyzed factors that contribute to the pleuropulmonary infection with Dirofilaria. There is mentioned the possibility of strain differences between Dirofilaria repens, distributed in various regions of Russia and abroad, and there are discussed the problems of treatment.
Comparative study of antibiotic resistance of V. Cholerae non O1/ non O139 strains isolated from humans in the Rostov region in various years
Authors: Selyanskaya N. A , Verkina I. M , Bereznyak E. A , Titova S. V , Zheleznyak N. G , Arkhangelskaya I. V
Published: April 2021

Purpose: to estimate the antibiotic resistance of Vibrio cholerae non О1/non О139 strains isolated from humans in the RostovRegion over the last 45 years. Materials and methods. Eighty six strains of V. cholerae non О1/non О139 (ctx-tcp-) were tested which had been isolated from humans in the Rostov region in 1968-2014. Antibiograms of strains tested were determined by the method of serial dilutions in solid medium. Results. In 2005-2014, as compared to 1968-1975, strains possessing multiple antibiotic resistance grew in number whereas the number of susceptible cultures decreased. The antimicrobial sensitivy spectrum of V.cholerae non О1/non О139 strains is consistent with previous records of high genome plasticity and variability of these strains. Conclusion. For successful etiotropic therapy and prevention of resistant strains spread the monitoring of antibiotic sensitivy is needed of each isolated clinical culture with subsequent timely replacement of antimicrobial in case of its inefficiency.
About assessment of the methodology of the epidemiological situation
Authors: Kolpakov S. L , Yakovlev A. A
Published: April 2021

Objective: the study of methods for the assessment of the prevalence and development of methodology for evaluation of the epidemiological situation in the RF subjects during the calendar year. The condition of an objective evaluation is the use of external criteria. Therefore, the assessment of one or another administrative territory is performing accordingly to the distribution of morbidity rate in separate subjects of the Russian Federation. As a criterion there is proposed to use the average prevalence of the subject of the Russian Federation - the median and its confidence limits with 95% significance. As a tool for grading of the scale there are considered as the total confidence interval, as possibilities of transition to centile method. There were elaborated methodical principles of the evaluation of the epidemiological situation. The base is the position that the objective, in territorial aspect may be the estimation only of the role of the stable factors. At the first stage the epidemiological situation should be to assessed on the theoretical prevalence of the year under consideration or on the forecast. Later, after the performing of the retrospective epidemiological analysis of morbidity in the subject and establishing the role of the determinants of the epidemic process in the index of considered year (internal control) it is possible to make adjustment and newly re-assess the epidemiological situation.
Clinical picture of influenza caused by a different virus serotypes
Authors: Popov A. F , Simakova A. I , Dmitrenko K. A , Zenin I. V
Published: April 2021

There was analyzed the medical history of 561 patients with influenza during the period of 2009-2014, Influenza A (H1N1) pdm09 was diagnosed in 261 cases, accounting for 46.5% of the total number of patients; Influenza A (H1N1) - in 148 cases (26.4%); Influenza A (H3N2) - in 102 cases (18.2%); Influenza B - in 50 cases (8.9%). The clinical picture of influenza A (H1N1) pdm09 differed from seasonal influenza A (H1N1), A (H3N2), and B by more severe course, the high rate of complications and mortality.
The 80 th anniversary year of the Rostov-On-Don Research Anti-Plague Institute. A glance into the past, present-day achievements in the sphere of investigations of especially dangerous diseases
Authors: Titova S. V , Shchipeleva I. A , Markovskaya E. I , Kruglikov V. D , Kuchin V. V
Published: April 2021

Information presented in this article gives an overview of scientific and practical activities of the Rostov-on-Don Anti-Plague Institute which celebrated its 80th anniversary in 2014. Two scientific conferences were dedicated to this event: the scientific conference of the Commission for the problem "Cholera and human pathogenic vibrios" was held on June 4-5, 2014 in the context of the Conference of specialists of the Federal Agency on Consumer Rights Protection and Human Welfare Supervision on advancement of cholera epidemiological surveillance. On November 25, 2014 the summing up scientific-practical conference, dedicated to the 80th anniversary of the Rostov-on-Don Anti-Plague Institute took place.
Change of antibiotic-resistant nosocomial microflora: Results of implementation of the strategy for control of antimicrobial treatment in multi speciality in-patient hospital
Authors: Gusarov V. G , Nesterova E. E , Lashenkova N. N , Petrova N. V , Silaeva N. A , Tertitskaya A. B , Teplykh B. A , Gorokhovatsky Yu. I , Zamyatin M. N
Published: April 2021

The unreasonable use of antimicrobial preparations is the one of leading causes of the increase of microbial resistance to antibiotics in in-patient departments. With the aim of containment of the resistance of nosocomial flora in multi-disciplinary in-patient hospital during two years there is used Antimicrobial Stewardship Program (ASP) with the involvement of a team of specialists in appropriate antibiotic therapy, protocols of perioperative antibiotic prophylaxis and empiric antibiotic therapy (EAT), educational programs for personal and measures for the assessment of the efficacy of ASP. The efficacy was evaluated with the use of such indices as the change of the pattern of nosocomial germs, incidence of methicillin-resistant Staphylococcus spp., vancomycin-resistant strains of Enterococcus faecium (VRE), incidence of extended-spectrum beta-lactamases(ESBL)-producing microorganisms, prevalence of carbapenem-resistant gram-negatives, drug resistance index (DRI). Implementation of ASP allowed to properly change the structure of nosocomial germs, to attain the real decline of the incidence of methicillinresistant Staphylococcus aureus (MRSA) from 16,2% (95%CI: 12-20,4) to 10,4% (95%CI: 7-13,8), p
Typical Problems of the Development of the Social Infrastructure of а Smаll Town in Modern Russian Conditions
Authors:   Russian State Social University, Medvedeva N.V. , Slemzina A.M. ,   Russian State Social University
Published: April 2021

the quality of life of the population of the municipality depends on the level of development of social infrastructure facilities. The purpose of the article is to develop recommendations for the development of the social infrastructure of a small town based on an analysis of the activities of local governments in the urban settlement of Balabanovo, Kaluga region. In the course of the study, both general theoretical methods (analysis and synthesis, comparison, generalization) and empirical methods (document analysis, content analysis, questionnaire survey) were used. As a result of the study, the key problems of the development of the social infrastructure of a typical small town were identified: lack of the necessary specialists; training in two shifts, insufficient number of specialized classes in educational institutions; insufficient number of sports and cultural infrastructure facilities and their poor material equipment. In order to resolve the identified problems, recommendations were developed to local authorities on the modernization of the city’s social infrastructure.
Distance Learning in a Pandemic: Challenges and Risks
Authors:   Russian State Social University, Rogach O.V. , Frolova E.V. ,   Russian State Social University
Published: April 2021

the article presents generalized materials for analyzing the problems of digitalization of the educational space in the context of the pandemic. The key research method was a questionnaire survey of students (N = 146 people) conducted online. The study allowed to establish the presence of a number of problems associated with the decline of students’ motivation and loss of interest in activities. Communication via gadgets allowed students to reduce their responsibility for organizing their workplace, move away from the practice of taking notes, and listen to lectures in the background. It is concluded that the control function of the teacher is reduced in the conditions of online learning, which together creates the risks of excluding the student from the educational process. It is also concluded that there are risks associated with a lack of communication channels and feedback dysfunctions in the “teacher – student” system. The risk of reducing the quality of professional training of students due to insufficient assimilation of material, weak development of flexible skills (creativity, self-presentation skills, etc.) in online learning is identified.
Self-Preservation Behavior of the Russian Family in the Context of the Coronavirus Pandemic (COVID-19)
Authors:   National Research Ogarev Mordovia State University, Savinov L.I. , Kamyshova E.V. ,   National Research Ogarev Mordovia State University
Published: April 2021

based on the analysis of the problems of the Russian family in the conditions of COVID-19, the article reveals the specifics and significance of its self-preservation behavior. Examples of such behavior in a pandemic are given, and a General conclusion is made about its viability, but problematic issues are also identified. Recommendations are made in the field of social policy to optimize the use of the potential of this type of behavior for the family to get out of the current crisis.
Safety of the Information Space for Children: Mastering New Competencies
Authors:   National Research Ogarev Mordovia State University, Savinov L.I. , Ryabova E.N. ,   Federal Centre for Educational Legislation
Published: April 2021

the article reflects the results of a study carried out in the Republic of Mordovia on the problem of creating a safe information sphere for children. The presented results characterize the interests of children in the use of information and communication technologies before and during distance learning in connection with COVID-19. During distance learning, children have increased the time they spend at the computer, on the global Internet. This leads to increased risks and threats to children in the information space. The efforts of the state and society should be aimed at creating a safe information space for children.
Matrix of Stages and Process Tools Within the Organizational and Management Mechanism for Providing Services in the System of Long-Term Care for Older Citizens Based on Public-Private Partnership
Authors:   Russian State Social University, Samofatova K.A.
Published: April 2021

the article describes a matrix of stages and process tools developed on the basis of algorithms of legal, organizational, technical and financial processes, consisting of a set of stages, processes and tools necessary for the implementation of an infrastructure PPP project in the field of social services, the strict implementation of which will lead to the effective functioning of the organizational and managerial mechanism for providing services in the framework of long-term care for elderly citizens on the basis of publicprivate partnership (PPP), reflecting the interaction between public and private parties within the framework of a concession agreement for the object of social or medical infrastructure with the participation of public, insurance and credit institutions.
Social Well-Being of the Elderly During the Period of Self-Isolation
Authors:   National Research Ogarev Mordovia State University, Bistiakina D.A. , Soloveva T.V. ,   National Research Ogarev Mordovia State University, Pankova E.G. ,   National Research Ogarev Mordovia State University
Published: April 2021

the article presents the results of the author’s research carried out within the framework of the scientific project “Transforming the social well-being of war veterans in the context of Russian transformations at the regional level”, analyzing the social well-being of older people during the period of the introduction of the forced self-isolation regime due to the danger of the spread of coronavirus infection. The role of state and public social organizations in mitigating the consequences of forced self-isolation of older people is revealed.
New Trends in the Digitalization of Social Welfare and Social Services in Russia
Authors:   Perm State National Research University, Gasumova S.E. , Karpunina A.V. ,   Russian State Social University
Published: April 2021

in the article on the basis of the network approach, a scientific analysis of trends in the digitalization of social welfare and social services is proposed, the stages of this process are highlighted. The features of interaction of social work subjects with citizens in the context of digitalization in Russia are shown. Particular emphasis is placed on the inevitability of accelerating the introduction of digital technologies under the influence of the self-isolation regime due to the COVID-19 pandemic in 2020. Based on a number of empirical studies conducted in the Perm Region in 2019–2020, the problems and prospects of digitalization of the social welfare system and social services are described, new trends in this area are shown. We also is analyze the formation of informal communities in the virtual space, allowing the population to independently create additional, alternative channels of self-information about measures of social support or social services. Some recommendations are proposed for improving the process of digitalization of social welfare and social services, some expectations of society in this direction are shown.
Typology of Models of Modern Paternity (On the Example of the Vologda Region and the Republic of Tatarstan)
Authors:   Vologda Scientific Center of the Russian Academy of Sciences, Gruzdeva M.A. , Kalachikova O.N. ,   Vologda Scientific Center of the Russian Academy of Sciences
Published: April 2021

the article presents an analysis of the economic foundations of the variability of models of generative behavior of Russian men. A hypothesis of research is a connection between the contribution to the material support of the family and the implementation of parenting functions, supported by reasons that are objective from the point of view of the family and causing the preservation of patriarchal stereotypes when building parent-matrimonial relations. The information base of the study was a qualitative sociological study on the generative behavior of men conducted in the Vologda region and the Republic of Tatarstan in 2019. A typology of models of behavior of modern fathers are proposed, depending on their contribution to the material support of the family, five types typical for complete families are distinguished. The developed typology is a hypothesis, it will be studied during a mass survey of men with using economic and mathematical methods.
Inclusive Shifts in Children’s Health Camps for Disabled Children and Children with Disabilities: Difficulties and Prospects (On the Example of GAUK «MOSGORTUR»)
Authors:   State autonomous cultural institution of the city of Moscow «Moscow agency of the organization of rest and tourism», Zayarskaya G.V. , Fodorya A.Yu. ,   State autonomous cultural institution of the city of Moscow «Moscow agency of the organization of rest and tourism», Revutskaya A.O. ,   State autonomous cultural institution of the city of Moscow «Moscow agency of the organization of rest and tourism»
Published: April 2021

the article analyzes and summarizes the experience of GAUK “MOSGORTUR” in the preparation and organization of inclusive shifts in children’s health camps. To assess the quality of organization of inclusive shifts and develop practical recommendations aimed at further development of inclusive children’s recreation, the study used monitoring of preparation and conduct of inclusive shifts, a sample survey of parents and legal representatives of children with disabilities and children with disabilities, analysis of diaries of counselors and reports of administrative and teaching staff of children’s camps, an expert survey of representatives of the professional community. The educational environment of the inclusive change of the children’s camp becomes one of the means of socialization of disabled children and children with disabilities, their socio-cultural adaptation, career guidance, and overcoming social isolation.
Social Diagnostics As a Technology of Social Work with a Family Raising a Child with Disabilities
Authors:   Nosov Magnitogorsk State Technical University, Ispulova S.N. , Shumakova A.A. ,   Nosov Magnitogorsk State Technical University
Published: April 2021

this article is devoted to the study of the psychological type of parenting of participants in the school of parents in the framework of the project “Platform for family co-creation – growing together” of the “Metallurg” Charitable Foundation. The authors present an analysis of the results of a study on the interest of parents of children with disabilities in attending classes. On the basis of the obtained data, we have developed recommendation-based lesson plans aimed at improving the pedagogical literacy of parents raising children with special needs, as well as preventing undesirable negative consequences.
Social Therapy in Working with Children with Disabilities (On the Example of the Project «Family Co-creation Platform – Growing Together»)
Authors:   Nosov Magnitogorsk State Technical University, Ispulova S.N. , Nesterova K.E. ,   Nosov Magnitogorsk State Technical University
Published: April 2021

this article is devoted to the definition of the role of social therapy in working with children with disabilities. The article presents the results of a study conducted on the basis of the Metallurg Charitable Foundation during the implementation of the project “Platform for family Co-creation – Growing together”. Judging by the results of the survey, the volunteers are interested in this technology and its methods. Recommendations were developed for volunteers in the form of a database of therapeutic techniques in the social network “VKontakte”, which can be actively used not only by volunteers in the framework of this project, but also by parents of children with disabilities at home.