bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomic analysis reveals proteins and pathways associated with declined testosterone production in male obese mice after chronic high-altitude exposure
Authors: Wang Shuqiong , Wei Youwen , Hu Caiyan , Liu Fang
Published: November 2022

Objective

Obesity is common in highland areas owing to lifestyle alterations. There are pieces of evidence to suggest that both obesity and hypoxia may promote oxidative stress, leading to hypogonadism in males. These findings indicate an increased risk of hypogonadism in obese males following hypoxia exposure. However, the mechanisms underlying the disease process remain unclear. The current study aims to explore the mechanism of testosterone production dysfunction in obese male mice exposed to a chronic high-altitude hypoxia environment.

Methods

An obese male mouse model was generated by inducing obesity in mice via a high-fat diet for 14 weeks, and the obese mice were then exposed to a high-altitude hypoxia environment for 24 days. Sera and testicular tissues were collected to detect serum lipids, sex hormone level, and testicular oxidative stress indicators. Morphological examination was performed to assess pathological alterations in testicular tissues and suborganelles in leydig cells. Proteomic alterations in testicular tissues were investigated using quantitative proteomics in Obese/Control and Obese-Hypoxia/Obese groups.

Results

The results showed that chronic high-altitude hypoxia exposure aggravated low testosterone production in obese male mice accompanied by increased testicular oxidative stress and histological damages. In total, 363 and 242 differentially expressed proteins (DEPs) were identified in the two comparison groups, Obese/Control and Obese-Hypoxia/Obese, respectively. Functional enrichment analysis demonstrated that several significant functional terms and pathways related to testosterone production were altered in the two comparison groups. These included cholesterol metabolism, steroid hormone biosynthesis, peroxisome proliferator-activated receptor (PPAR) signaling pathway, oxidative stress responses, as well as retinol metabolism. Finally, 10 representative DEPs were selected for parallel reaction monitoring verification. Among them, StAR, DHCR7, NSDHL, CYP51A1, FDPS, FDX1, CYP11A1, ALDH1A1, and GPX3 were confirmed to be downregulated in the two groups.

Conclusions

Chronic hypoxia exposure could exacerbate low testosterone production in obese male mice by influencing the expression of key proteins involved in steroid hormone biosynthesis, cholesterol biosynthesis, oxidative stress responses and retinol metabolism.
A radiomics nomogram for the ultrasound-based evaluation of central cervical lymph node metastasis in papillary thyroid carcinoma
Authors: Wen Quan , Wang Zhixiang , Traverso Alberto , Liu Yujiang , Xu Ruifang , Feng Ying , Qian Linxue
Published: November 2022

Purpose

To develop and validate a radiomics nomogram based on ultrasound (US) to predict central cervical lymph node (LN) metastasis in patients with papillary thyroid carcinoma (PTC).

Methods

PTC patients with pathologically confirmed presence or absence of central cervical LN metastasis in our hospital between March 2021 and November 2021 were enrolled as the training cohort. Radiomics features were extracted from the preoperative US images, and a radiomics signature was constructed. Univariate and multivariate logistic regression analyses were used to screen out the independent risk factors, and a radiomics nomogram was established. The performance of the model was verified in the independent test cohort of PTC patients who underwent thyroidectomy and cervical LN dissection in our hospital from December 2021 to March 2022.

Results

In the independent test cohort, the radiomics model based on long-axis cross-section and short-axis cross-section images outperformed the radiomics models based on either one of these sections (the area under the curve (AUC), 0.69 vs. 0.62 and 0.66). The radiomics signature consisted of 4 selected features. The US radiomics nomogram included the radiomics signature, age, gender, BRAF V600E mutation status, and extrathyroidal extension (ETE) status. In the independent test cohort, the AUC of the receiver operating curve(ROC) of this nomogram was 0.76, outperformingthe clinical model and the radiomics model (0.63 and 0.69, respectively), and also much better than preoperative US examination (AUC, 0.60). Decision curve analysis indicated that the radiomics nomogram was clinically useful.

Conclusions

This study presents an efficient and useful US radiomics nomogram that can provide comprehensive information to assist clinicians in the individualized preoperative prediction of central cervical LN metastasis in PTC patients.
Recent advances in the elimination of persistent organic pollutants by photocatalysis
Authors: Gaur Nisha , Dutta Dhiraj , Singh Ayushi , Dubey Rama , Kamboj Dev Vrat
Published: November 2022

The non-ending needs of growing human population are being met by rapid industrialization and globalization, which have nowadays become an indispensable component of growth. Although these activities have led to phenomenal growth of the human civilization, at the same time, they have resulted in severe environmental pollution by discharge of highly toxic waste. This waste is severely detrimental not only for the environment but also for the health of the human population. Among different classes of pollutants, one being considered as one of the highly toxic ones is that of persistent organic pollutants (POPs). Advanced oxidation technologies (AOTs) play a major role in the degradation of pollutants by converting organic pollutants into CO2, H2O, and mineralized inorganic ions. AOTs include UV-based photocatalysis, ozonation, electrochemical oxidation, and Fenton and Fenton-like processes There are some difficulties and challenges associated with AOT, such as being highly capital intensive and high consumption of energy. To overcome these bottlenecks, photocatalytic degradation is a promising method that uses solar energy for the degradation of such pollutants. Photocatalysis is further classified into homogenous and heterogenous photocatalysis. As a part of heterogenous photocatalysis, semiconductor photocatalysts have received great attention; but because of their drawbacks such as the recombination of the electron/hole pair, low adsorption rate, and low surface area coverage, nanotechnology was considered for bringing a novel and enhanced remediation photocatalysis process. To this end, the designing of a more efficient photocatalyst by modifying morphology, composition, and structure and reducing toxicity is the need of the hour for the abatement of environmental pollutants. This review focuses on the degradation and removal of highly toxic persistent organic pollutants by using photocatalytic degradation with a detailed account of the various pollutants, their degradation mechanism, process shortcomings, remedial measures, and future prospects.
Integrity of virtual testing for crash protection
Authors: Galijatovic Esma , Eichlseder Maria , Heindl Simon Franz , Klug Corina
Published: November 2022

The interest in virtual testing is globally rapidly increasing because of several advantages compared to physical tests in laboratories. In the area of passive car safety, finite element simulations can be used to get further insights, use more biofidelic human models and make the overall assessment more robust by incorporating more variety in the virtual testing load cases. For a successful implementation of virtual testing in regulations or consumer information, the integrity of the procedure has to be ensured. As car simulation models used within the virtual testing are usually not shared with the evaluation institutions due to intellectual property (IP) issues, this is a challenging task. Stringent validation and certification procedures are needed and it has to be ensured that the models used in these steps are the same as the ones used for the virtual testing. In this paper, we developed a secure procedure for model version control. Through analysis of possible threats for both sides, car manufacturer and evaluation institution, we defined requirements, which the new procedure should satisfy. These requirements state that the integrity and authenticity of all shared documents should be protected, as well as the confidentiality of the simulation model. By considering all prerequisites, we developed an architecture for a new procedure. This architecture uses cryptographic algorithms such as hash functions and digital signatures to ensure integrity and authenticity, as well as secure computation mechanisms such as Intel Software Guard Extensions (SGX). In our proof-of-concept implementation, we demonstrated how a secure wrapper around LS-DYNA can produce a signed report to authenticate the input model files based on a hash tree and link them to the simulation results. The evaluation institution can use a matching verification tool to verify that the models were not manipulated compared to other simulation runs or the qualification process. The developed procedure can be used for trustworthy implementation of virtual testing into consumer information or regulation for the assessment of car safety with strengthened integrity. Further research is needed to develop comparable procedures for other simulation software packages or ideally integrate it directly into the simulation software.
piRNAs may regulate expression of candidate genes of esophageal adenocarcinoma
Authors: Akimniyazova A. N. , Niyazova T. K. , Yurikova O. Yu. , Pyrkova A. Yu. , Zhanuzakov M. A. , Ivashchenko A. T.
Published: November 2022

Elucidation of ways to regulate the expression of candidate cancer genes will contribute to the development of methods for cancer diagnosis and therapy. The aim of the present study was to show the role of piRNAs as efficient regulators of mRNA translation of esophageal adenocarcinoma (EAC) candidate genes. We used bioinformatic methods to study the interaction characteristics of up to 200 thousand piRNAs with mRNAs of 38 candidate EAC genes. The piRNAs capable of binding to mRNA of AR, BTG3, CD55, ERBB3, FKBP5, FOXP1, LEP, SEPP1, SMAD4, and TP53 genes with high free energy by the formation of hydrogen bonds between canonical (G-C, A-U) and noncanonical (G-U, A-C) piRNA and mRNA nucleotide pairs were revealed. The organization of piRNA binding sites (BSs) in the mRNA of candidate genes was found to overlap nucleotide sequences to form clusters. Clusters of piRNA BSs were detected in the 5′-untranslated region, coding domain sequence, and 3′-untranslated region of mRNA. Due to the formation of piRNA binding site clusters, compaction of BSs occurs and competition between piRNAs for binding to mRNA of candidate EAC genes occurs. Associations of piRNA and candidate genes were selected for use as markers for the diagnosis of EAC.
Radiation exposure to nuclear medicine technologists performing a V/Q PET: Comparison with conventional V/Q scintigraphy, [18F]FDG PET and [68Ga]Ga DOTATOC PET procedures
Authors: Blanc-Béguin Frédérique , Damien Pascal , Floch Romain , Kerleguer Kévin , Hennebicq Simon , Robin Philippe , Salaün Pierre-Yves , Le Roux Pierre-Yves
Published: November 2022

Introduction

Ventilation/Perfusion (V/Q) PET/CT is an emerging imaging modality for regional lung function evaluation. The same carrier molecules as conventional V/Q scintigraphy are used but they are radiolabelled with gallium-68 (68Ga) instead of technetium-99m (99mTc). A recurrent concern regarding V/Q PET imaging is the radiation dose to the healthcare workers. The aim of this study was to evaluate the total effective dose and the finger dose received by the technologist when performing a V/Q PET procedure, and to compare them with the radiations doses received with conventional V/Q scintigraphy, FDG PET and Ga DOTATOC PET procedures.

Materials and methods

The whole body dose measurement was performed 10 times for each of the evaluated procedures using an electronic personal dosimeter (ED). For V/Q PET and V/Q scintigraphy procedures, ventilation and perfusion stages were separately evaluated. Internal exposure was measured for ventilation procedures. Finger dose measurements were performed 5 times for each of the PET procedures using Thermoluminescence (TL) pellets.

Results

The technologist effective dose when performing a V/Q PET procedure was 2.83 ± 0.67 μSv, as compared with 1.16 ± 0.34 μSv for conventional V/Q scintigraphy, 2.13 ± 0.77 μSv for [68Ga]Ga-DOTATOC, and 2.86 ± 1.79 μSv for FDG PET procedures, respectively. The finger dose for the V/Q PET procedure was similar to the dose for a [68Ga]Ga-DOTATOC scan (0.35 mSv and 0.32 mSv, respectively).

Conclusion

The technologist total effective dose for a V/Q PET procedure is ~2.4 higher than the dose for a conventional V/Q scintigraphy, but in the same range than the radiation exposure when performing common PET procedures, both in terms of total effective dose or finger dose. These results should be reassuring for the healthcare workers performing a V/Q PET procedure.
Immunogenicity of inactivated coronavirus disease 2019 vaccines in patients with chronic hepatitis B undergoing antiviral therapy
Authors: Wang Wen-Xin , Jia Rui , Song Jin-Wen , Zhang Xiaoning , Zhou Shuang-Nan , Wang Fu-Sheng , Fu Junliang
Published: November 2022

Objectives

To investigate the effect and its mechanisms of different antiviral agents on the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with chronic hepatitis B (CHB).

Methods

A total of 125 patients with CHB receiving nucleos(t)ide analogs (NAs) monotherapy or combined with Peg-interferon-alpha (Peg-IFNα) therapy and 29 healthy controls (HCs) were enrolled. Adverse reactions (ADRs) and levels of neutralizing antibody (NAb), immunoglobulin G (IgG), immunoglobulin M (IgM), and peripheral cytokines post-vaccination were analyzed.

Results

All ADRs were tolerable in CHB patients. Overall, no significant difference was observed in the antibody levels between patients and HCs after two doses of vaccination. An inverse correlation between NAb, IgG titers and the days after two doses was found in non-IFN group but not in IFN group. Correspondingly, peripheral interferon-γ levels were significantly higher in IFN group than in non-IFN group. After a booster dose, NAb and IgG antibodies were maintained at high levels in NA-treated patients.

Conclusion

Peg-interferon-alpha-based therapy may be beneficial for maintaining the immunogenicity of SARS-CoV-2 vaccines in CHB patients, which may be related to the high levels of IFN-γ induced by Peg-IFNα therapy. A booster dose can effectively recall the robust and long-lasting immunogenicity of SARS-CoV-2 vaccines.
Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses
Authors: Wei Xiaoya , Wang Liqiong , Yu Fangting , Lee Chihkai , Liu Ni , Ren Mengmeng , Tu Jianfeng , Zhou Hang , Shi Guangxia , Wang Xu , Liu Cun-Zhi
Published: November 2022

Introduction

Sciatica is a pain disorder often caused by the herniated disk compressing the lumbosacral nerve roots. Neuroimaging studies have identified functional abnormalities in patients with chronic sciatica (CS). However, few studies have investigated the neural marker of CS using brain structure and the classification value of multidimensional neuroimaging features in CS patients is unclear.

Methods

Here, structural and resting-state functional magnetic resonance imaging (fMRI) was acquired for 34 CS patients and 36 matched healthy controls (HCs). We analyzed cortical surface area, cortical thickness, amplitude of low-frequency fluctuation (ALFF), regional homogeneity (REHO), between-regions functional connectivity (FC), and assessed the correlation between neuroimaging measures and clinical scores. Finally, the multimodal neuroimaging features were used to differentiate the CS patients and HC individuals by support vector machine (SVM) algorithm.

Results

Compared to HC, CS patients had a larger cortical surface area in the right banks of the superior temporal sulcus and rostral anterior cingulate; higher ALFF value in the left inferior frontal gyrus; enhanced FCs between somatomotor and ventral attention network. Three FCs values were associated with clinical pain scores. Furthermore, the three multimodal neuroimaging features with significant differences between groups and the SVM algorithm could classify CS patients and HC with an accuracy of 90.00%.

Discussion

Together, our findings revealed extensive reorganization of local functional properties, surface area, and network metrics in CS patients. The success of patient identification highlights the potential of using artificial intelligence and multimodal neuroimaging markers in chronic pain research.
Nocturnal mosquito Cryptochrome 1 mediates greater electrophysiological and behavioral responses to blue light relative to diurnal mosquito Cryptochrome 1
Authors: Au David D. , Liu Jenny C. , Nguyen Thanh H. , Foden Alexander J. , Park Soo Jee , Dimalanta Mia , Yu Zhaoxia , Holmes Todd C.
Published: November 2022

Nocturnal Anopheles mosquitoes exhibit strong behavioral avoidance to blue-light while diurnal Aedes mosquitoes are behaviorally attracted to blue-light and a wide range of other wavelengths of light. To determine the molecular mechanism of these effects, we expressed light-sensing Anopheles gambiae (AgCRY1) and Aedes aegypti (AeCRY1) Cryptochrome 1 (CRY) genes under a crypGAL4-24 driver line in a mutant Drosophila genetic background lacking native functional CRY, then tested behavioral and electrophysiological effects of mosquito CRY expression relative to positive and negative CRY control conditions. Neither mosquito CRY stops the circadian clock as shown by robust circadian behavioral rhythmicity in constant darkness in flies expressing either AgCRY1 or AeCRY1. AgCRY1 and AeCRY1 both mediate acute increases in large ventral lateral neuronal firing rate evoked by 450 nm blue-light, corresponding to CRY’s peak absorbance in its base state, indicating that both mosquito CRYs are functional, however, AgCRY1 mediates significantly stronger sustained electrophysiological light-evoked depolarization in response to blue-light relative to AeCRY1. In contrast, neither AgCRY1 nor AeCRY1 expression mediates measurable increases in large ventral lateral neuronal firing rates in response to 405 nm violet-light, the peak of the Rhodopsin-7 photoreceptor that is co-expressed in the large lateral ventral neurons. These results are consistent with the known action spectra of type 1 CRYs and lack of response in cry-null controls. AgCRY1 and AeCRY1 expressing flies show behavioral attraction to low intensity blue-light, but AgCRY1 expressing flies show behavioral avoidance to higher intensity blue-light. These results show that nocturnal and diurnal mosquito Cryptochrome 1 proteins mediate differential physiological and behavioral responses to blue-light that are consistent with species-specific mosquito behavior.
Understanding creativity process through electroencephalography measurement on creativity-related cognitive factors
Authors: Yin Yuan , Wang Pan , Childs Peter R. N.
Published: November 2022

Introduction

Neurotechnology approaches, such as electroencephalography (EEG), can aid understanding of the cognitive processes behind creativity.

Methods

To identify and compare the EEG characteristics of creativity-related cognitive factors (remote association, common association, combination, recall, and retrieval), 30 participants were recruited to conduct an EEG induction study.

Results

From the event-related potential (ERP) results and spectral analysis, the study supports that creativity is related to the frontal lobe areas of the brain and common association is an unconscious process.

Discussion

The results help explain why some creativity-related cognitive factors are involved either more or less readily than others in the creative design process from workload aspects. This study identifies the part of the brain that is involved in the combination cognitive factor and detects the ERP results on cognitive factors. This study can be used by designers and researchers to further understand the cognitive processes of creativity.
Promising bioactive properties of quercetin for potential food applications and health benefits: A review
Authors: Shabir Irtiqa , Kumar Pandey Vinay , Shams Rafeeya , Dar Aamir Hussain , Dash Kshirod Kumar , Khan Shafat Ahmad , Bashir Iqra , Jeevarathinam G. , Rusu Alexandru Vasile , Esatbeyoglu Tuba , Pandiselvam R.
Published: November 2022

Naturally occurring phytochemicals with promising biological properties are quercetin and its derivatives. Quercetin has been thoroughly studied for its antidiabetic, antibacterial, anti-inflammatory, anti-Alzheimer's, anti-arthritic, antioxidant, cardiovascular, and wound-healing properties. Anticancer activity of quercetin against cancer cell lines has also recently been revealed. The majority of the Western diet contains quercetin and its derivatives, therefore consuming them as part of a meal or as a food supplement may be sufficient for people to take advantage of their preventive effects. Bioavailability-based drug-delivery systems of quercetin have been heavily studied. Fruits, seeds, vegetables, bracken fern, coffee, tea, and other plants all contain quercetin, as do natural colors. One naturally occurring antioxidant is quercetin, whose anticancer effects have been discussed in detail. It has several properties that could make it an effective anti-cancer agent. Numerous researches have shown that quercetin plays a substantial part in the suppression of cancer cells in the breast, colon, prostate, ovary, endometrial, and lung tumors. The current study includes a concise explanation of quercetin's action mechanism and potential health applications.
Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children
Authors: Rivera-Luna Roberto , Perez-Vera Patricia , Galvan-Diaz Cesar , Velasco-Hidalgo Liliana , Olaya-Vargas Alberto , Cardenas-Cardos Rocio , Aguilar-Ortiz Marco , Ponce-Cruz Jesus
Published: November 2022

Acute lymphoblastic leukemia (ALL) is the most common malignancy among Mexican and Hispanic children and the first cause of death by disease in Mexico. We propose a “triple-hit” explanation for the survival gap affecting this population. The first hit can be attributed to epidemiology and social, cultural, and economic burdens. The second hit refers to cancer biology, with a high incidence of unfavorable genetic characteristics associated with an unfavorable response to treatment and, subsequently, poor survival. Finally, the third hit relates to sub-optimal treatment and support. Society and culture, leukemia biology, and treatment approach limitations are key factors that should not be seen apart and must be considered comprehensively in any strategy to improve the prognosis of Mexican and Hispanic children with ALL.
Recurrent pericarditis in a patient with Bardet–Biedl syndrome: A case report
Authors: Mauro Angela , Casini Francesca , Congedo Emanuele Chittano , L’assainato Sara , Pinto Francesca , Ansuini Valentina , Mascolo Ruggiero , Pedroli Alice , Bernardo Luca
Published: November 2022

Bardet–Biedl syndrome is a rare autosomal recessive disorder characterized by rod-cone dystrophy, renal dysfunction, obesity, learning difficulties, hypogonadism, polydactyl, and many other minor features that can affect the cardiovascular, locomotive, neurological, and endocrine systems. We report the case of a 16-year-old boy affected by Bardet–Biedl syndrome who presented with recurrent pericarditis with an optimal response to treatment with Anakinra. To our knowledge, this is the first description of an association between Bardet–Biedl syndrome and recurrent pericarditis.
Amalgamation of high-κ dielectrics with graphene: A catalyst in the orbit of nanoelectronics and material sciences
Authors: Khanna Sadhak
Published: November 2022

In electronics, the size of transistors has been reduced to a few nanometers. Electronic devices’ accuracy and authenticity face a major problem of leakage current. To solve this tricky situation, high-κ dielectrics which have a huge band gap and permittivity are established to increase the capacitance and remove the leakage current. Three major properties are related to current flow: 1) band gap, 2) resistance, and 3) dielectric constant. High-κ or higher dielectric constant shows how much charge a material can hold. A large band gap is needed to vanquish charge injection that causes leakage current. So, these are the insulating materials that store charges when placed in between metallic plates. The dielectric thickness of high-κ can be enhanced without enhancing the capacitance, hence reducing the leakage current. These materials need to be functionalized. Materials with low physical and chemical barriers need to be functionalized with them. The best material to be integrated with these high-κ dielectrics is graphene, as the goal of large area uniformity of electrical properties is achievable with this and easily separable graphene is also available. Here, we will scrutinize the current advancement in graphene electronics-based research on high-κ dielectrics such as Al₂O₃ (used as obstructing oxide in charge trap flash memory) with graphene. This article reviews the amalgamation of oxides such as high-κ dielectrics with graphene, which are necessary for the understanding of top-gated electronic devices made by graphene which includes field-effect transistors and other electronic devices.
Enhancement of the DOA detection performance through optimization of the steering matrix of the array
Authors: Xiao Guoyao , Liao Guisheng
Published: November 2022

Direction Of Arrival (DOA) of signals detection technology is an important vehicle in the field of in remote sensing, radar, wireless communication. In this study, we elaborate on an enhanced method to detect the DOA. In the developed scheme, we mainly focus on solving the steering matrix of the array which contains all the information of the signals. The iterative relation between the steering matrix and the signal vector is first established on the basis of the equation of the array output. Then, to get a more accurate of steering matrix, we construct a cost function that aims to minimize some signal subspace error. In the optimization process of the developed scheme, we also set a constraint for the steering matrix which can effectively eliminate convergence on local optimum and also reduce the number of iterations. Subsequently, the steering matrix of the array can be recovered faithfully. Finally, the DOA can be solved from the estimated steering matrix. Explicit analysis and derivation of the proposed scheme are presented.
Integrated model for genomic prediction under additive and non-additive genetic architecture
Authors: Budhlakoti Neeraj , Mishra Dwijesh Chandra , Majumdar Sayanti Guha , Kumar Anuj , Srivastava Sudhir , Rai S. N. , Rai Anil
Published: November 2022

Using data from genome-wide molecular markers, genomic selection procedures have proved useful for estimating breeding values and phenotypic prediction. The link between an individual genotype and phenotype has been modelled using a number of parametric methods to estimate individual breeding value. It has been observed that parametric methods perform satisfactorily only when the system under study has additive genetic architecture. To capture non-additive (dominance and epistasis) effects, nonparametric approaches have also been developed; however, they typically fall short of capturing additive effects. The idea behind this study is to select the most appropriate model from each parametric and nonparametric category and build an integrated model that can incorporate the best features of both models. It was observed from the results of the current study that GBLUP performed admirably under additive architecture, while SVM’s performance in non-additive architecture was found to be encouraging. A robust model for genomic prediction has been developed in light of these findings, which can handle both additive and epistatic effects simultaneously by minimizing their error variance. The developed integrated model has been assessed using standard evaluation measures like predictive ability and error variance.
Genetic variation in morphological traits in cotton and their roles in increasing phosphorus-use-efficiency in response to low phosphorus availability
Authors: Kayoumu Mirezhatijiang , Li Xiaotong , Iqbal Asif , Wang Xiangru , Gui Huiping , Qi Qian , Ruan Sijia , Guo Ruishi , Dong Qiang , Zhang Xiling , Song Meizhen
Published: November 2022

Phosphorus (P) is an essential macronutrient required for fundamental processes in plants. Trait plasticity is crucial for plant adaptation to environmental change. Variations in traits underlie diverse phosphorus (P) acquisition strategies among plants. Nevertheless, how the intraspecific plasticity and integration of morphological traits contribute to Phosphorus-Use-Efficiency (PUE) in cotton is unknown. In this study, 25 morphological traits were evaluated in 384 cotton genotypes grown with low P (LP, 10μmol. L−1) and normal nutrition (CK, 500μmol. L−1) to assess the genetic variability of morphological traits and their relationship to phosphorus use efficiency. Results revealed a large genetic variation in mostly morphological traits under low P. Significant enhancement in root traits and phosphorus efficiency-related traits like PUE was observed at LP as compared to CK conditions. In response to low P availability, cotton genotypes showed large plasticity in shoot and total dry biomass, phosphorus, and nitrogen efficiency-related traits (i.e., phosphorus/nitrogen use efficiency, phosphorus/nitrogen uptake efficiency), and most root traits, but a limited response in root dry biomass, taproot length, root surface area, root volume, and SPAD value. In addition, significant correlations were observed between PUtE (phosphorus uptake efficiency), NUE (nitrogen use efficiency), TDB (total dry biomass), and RTD (root tissue density) with PUE under both P supply level and phosphorus stress index, which may be a key indicator for improving PUE under LP conditions. Most root traits are most affected by genotypes than nutrition level. Conserved PUE is more affected by the nutrition level than the genotype effect. Principal component analysis depicted the comprehensive indicators under two P supply conditions were mainly reflected in root-related traits and morphological indicators such as dry matter biomass. These results indicate that interspecific variations exist within these cotton genotypes and traits. Our study provides suggestions for future research to enhance the ability of the earth system model to predict how crops respond to environmental interference and provide target quality for cotton breeding in phosphorus-deficient areas.
Dynamic analysis of the determinants of long-term microfinance interest rates: Macro and micro factors
Authors: Rauf Fawad , Wanqiu Wang , Jing Li , Qadri Syed Usman , Naveed Khwaja , Rahman Shams U.
Published: November 2022

Introduction

A recent increase in interest rates has raised doubts about the stability of micro-finance institutions (MFI) A recent increase in interest rates has raised doubts about the stability of MFI in many countries. This has compelled governments to consider some MFI practices unethical.

Methods

This paper studies the MFI interest rates by using a dynamic panel method to identify the determining factors of the viability, financial, and social execution of microfinance firms. The research shows that the long-term interest rate evolution depends on the anticipation of loan loss rates (LLR), profit, or macroeconomic factors like inflation and the short-term current interest rate. The Study used database of 897 microfinance institutions in 106 countries and six geographic regions with a representative sample size of 5,075 observations between 2008 and 2020. The external factors considered are the market structure (Competition), economics (inflation), cultural and technological political conditions, and banking regulations in effect (regulation). Financial costs, operational costs, the write-off rate, and the average size of the loan are the most important determinant factors in MFI interest rate fluctuations.

Results

The research find that other factors like gender, legal status, and regulations also contribute to the MFI interest rate variation. The research also discovered that there is a threshold effect in the relationship between women borrowers (WB) and the interest rate. Another important finding of this study is that MFIs do not anticipate inflation in the definition of the interest rate.

Discussion

From an institutional point of view, it is necessary to promote competition, as the study shows that well-regulated competition helps to keep interest rates at a reasonable level.
Importance of environmental policy on firm performance for the textile industry: A contextual study of Pakistan
Authors: Iqbal Tahir , Shahzad Muhammad Asim , Alonso-Nuez María J. , Rosell-Martínez Jorge
Published: November 2022

Global warming and air pollution are severe threats to humans and ecosystems. While some of these issues, particularly those on a small scale requiring low-cost behaviors, may be relieved by developing and implementing environmental policies, it is clear that legislative measures and behaviors requiring a significant degree of sacrifice are required. The goal of this research is to highlight the aspects that can contribute to improve organizational performance in Pakistan’s textile industry. Through the moderating function of environmentalism, the study examines the impact of public participation, government regulation, and organizational environmental management systems (EMSs) on environmental and organizational performance The findings show that public participation, government regulation, and the organizational EMS all have a significant impact on both environmental and organizational success. Data were collected via a survey questionnaire. Smart-PLS-3 was used to evaluate the data. Furthermore, if environmentalism is regarded as a moderator, the overall influence on organizational performance will be greater. Public participation, government regulations, and an organization’s EMS are all seen to have a substantial influence on both environmental and organizational success.
Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy
Authors: Shi Hui , Ren Honglin , Tian Ying , Chen Zhe , Xu Cuiping , Lu Lu , Ma Xiaoyu , Li Xiaoyan , Chen Wenming , Guo Tong , Fan Cuizhen , Gao Wen
Published: November 2022

Objective

To investigate the prevalence of depression or anxiety in patient with multiple myeloma (MM) in China during maintenance treatment and its associated influencing factors.

Methods

Patients with MM (n = 160) received maintenance therapy, and control subjects (without MM, n = 160) matched on age, sex, and BMI were recruited. Patients completed questionnaires, including the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7-item Scale (GAD-7), and the Verbal Pain Rating Scale (VPRS). Data on the Clinical characteristics, biochemical indicators of de novo MM were from the database of the Hematology Department of Beijing Chao-yang Hospital. Multiple linear regression model analysis was used to compare the differences in PHQ-9 and GAD-7 scale scores between the control group and the case group after correction for relevant variables. Multiple logistic regression models were subsequently used to analyze the correlation between the presence or absence of anxiety and depression and clinical indicators in the MM groups.

Results

Depression symptoms was present in 33.33% and anxiety symptoms in 24.68% of first-episode MM in the maintenance phase of treatment, and depression symptoms in the index-corrected MM group was significantly different from that in the control group (t = 2.54, P < 0.05). Analyses of multiple logistic regressions: biochemical indicators and clinical typing were not significantly associated with anxiety and depression. Compared to the pain rating 1, the risk of depressive mood was greater in the case group with the pain rating 2 (OR = 2.38) and the pain rating ≥ 3 (OR = 4.32). The risk of anxiety was greater in the case group with the pain rating ≥ 3 than the pain rating 1 (OR = 2.89).

Conclusion

Despite being in clinical remission, depressive mood problems in patients with MM remain prominent. Clinicians should enhance mood assessment and management in patients with concomitant pain.
Knowledge and practices toward COVID-19 among healthcare students: A cross-sectional study at the University of Zambia
Authors: Mudenda Steward , Ngalande Nelly , Mukosha Moses , Hikaambo Christabel Nang'andu , Daka Victor , Matafwali Scott Kaba , Banda Michelo , Mfune Ruth Lindizyani , Mayoka Godfrey , Witika Bwalya Angel
Published: November 2022

Background

The COVID-19 pandemic led to the disruption of physical classes for university students globally, as large gatherings fuelled the transmission of the virus. In the efforts to mitigate its transmission and return to normality, prevention measures, including vaccination, have been encouraged. Therefore, it is critical to understand the knowledge and practices of students regarding COVID-19. This study assessed the knowledge and practices toward COVID-19 among healthcare students at the University of Zambia.

Materials and methods

This questionnaire-based cross-sectional study was carried out from August 2021 to October 2021 among 478 healthcare students (pharmacy, physiotherapy, nursing, biomedical, medicine, and radiography). We used a previously validated questionnaire to measure knowledge and practice. The predictors of knowledge and practices were assessed using logistic regression with robust estimation of standard errors. Statistical analysis was conducted using Stata/BE version 17.0.

Results

Of the 478 respondents, 243 (50.8%) were females. A larger proportion, 175 (36.6%) were in Pharmacy training, and 156 (32.6%) were in their fifth year of study. The overall mean knowledge score of the participants was 87.9 (SD = 16.1), being higher at 89.6 (SD = 14.3) among medical students and the lowest at 86.7 (SD = 17.1) among Pharmacy students, although this was statistically non-significant (p = 0.488). The overall mean practice score was 60.0 (SD = 24.7), being significantly higher at 63.5 (23.4) among nursing, physiotherapy and environmental students compared to other students (p = 0.048). In multivariable analysis, the participant training program was non-significantly associated with knowledge and practice toward COVID-19. However, increased age (AOR = 1.09, 95% CI: 1.01–1.117) and residing in urban areas (AOR = 1.79, 95% CI: 1.07–3.01) than in rural areas were associated with higher odds of good practice toward COVID-19.

Conclusion

The healthcare students generally showed good knowledge levels and poor practices toward COVID-19. Further, there was no evidence of a difference in knowledge of COVID-19 among healthcare students. These findings suggest the need for implementation strategies to be centered on improving the practices of students toward COVID-19.
An interdisciplinary framework for derivation of occupational exposure limits
Authors: Maurer Laura L. , Alexander Melannie S. , Bachman Ammie N. , Grimm Fabian A. , Lewis R. Jeff , North Colin M. , Wojcik Nancy C. , Goyak Katy O.
Published: November 2022

Protecting the health and safety of workers in industrial operations is a top priority. One of the resources used in industry to ensure worker safety is the occupational exposure limit (OEL). OELs are derived from the assessment and interpretation of empirical data from animal and/or human studies. There are various guidelines for the derivation and implementation of OELs globally, with a range of stakeholders (including regulatory bodies, governmental agencies, expert groups and others). The purpose of this manuscript is to supplement existing guidance with learnings from a multidisciplinary team approach within an industry setting. The framework we present is similar in construct to other risk assessment frameworks and includes: (1) problem formulation, (2) literature review, (3) weight of evidence considerations, (4) point of departure selection/derivation, (5) application of assessment factors, and the final step, (6) derivation of the OEL. Within each step are descriptions and examples to consider when incorporating data from various disciplines such as toxicology, epidemiology, and exposure science. This manuscript describes a technical framework by which available data relevant for occupational exposures is compiled, analyzed, and utilized to inform safety threshold derivation applicable to OELs.
Snapping Shrimp and Their Crustaceous Cacophony
Authors: Jones Cian , Benvenuto Chiara , Kendrick Paul
Published: November 2022

We humans are a noisy bunch. Our sounds fill the land and air around us, and even the oceans and seas. But we are not the only ones filling the sea with sound. Tiny snapping shrimp, also known as pistol shrimp, are some of the loudest animals in the ocean! They capture their prey by blasting it with a powerful shockwave from an enlarged claw. While the sound from each individual shrimp is small, the noise they make as a group has been known to mask the presence of submarines! How does something so small make such a loud noise? How can scientists use this noise to better understand the health of the seabed?
Health Care Professionals’ Interest in Vaccination Training in Switzerland: A Quantitative Survey
Authors: Lucas Ramanathan Pia , Baldesberger Nadja , Dietrich Léna G. , Speranza Camilla , Lüthy Alyssa , Buhl Andrea , Gisin Martina , Koch Roswitha , Nicca Dunja , Suggs L. Suzanne , Huber Benedikt M. , Deml Michael J. , Tarr Philip E.
Published: November 2022

Objectives: Health care professionals (HCPs) play an important role for patients’ vaccination decisions. To counsel patients/clients appropriately, HCPs need current factual knowledge about vaccines and strong communication skills.

Methods: We conducted an online survey with physicians, pharmacists, nurses, and midwives in Switzerland (01.11.2020–31.03.2021). We evaluated: 1) interest in vaccination knowledge and counseling training; 2) vaccination recommendation practices; 3) experience with vaccination counseling/administration; 4) comfort level in addressing vaccine hesitancy (VH); 5) perspectives on patient/client VH, delays, and refusals.

Results: In total, 1,933 practicing HCPs responded (496 physicians, 226 pharmacists, 607 nurses, 604 midwives). 43% physicians, 31% pharmacists, 15% nurses, and 23% midwives felt comfortable counseling VH patients/clients. 96% physicians, 98% pharmacists, 85% nurses, and 91% midwives were interested in additional vaccination-related training. All professionals mentioned safety, efficacy, and side effects as topics of most interest for additional training.

Conclusion: Results demonstrate a high interest among HCPs for additional vaccination-related training. In addition to factual information about vaccination, such training will likely benefit from a communication component, given the low rates of comfort reported by HCPs when counseling VH patients/clients.
Experimental Evaluation of Modified Groundhook Car Suspension with Fast Magnetorheological Damper
Authors: Žáček Jiří , Šebesta Karel , Mohammad Housam , Jeniš Filip , Strecker Zbyněk , Kubík Michal
Published: November 2022

The car suspension setting is always a trade-off between comfort and handling. The semi-active damper system seems to be an option for reducing the compromise between the two demands. This paper deals with the effect of the magnetorheological damper setting on a car’s suspension performance, especially tire grip, which was directly measured. A unique test rig was developed, and an experimental trolley with a fast magnetorheological damper (response time of 3 µs) was used in the paper. The damper was controlled by a modified Groundhook algorithm. Compared with the passive regime, the experiments showed a 30% improvement when using the Groundhook algorithm and when the damper was adequately set. The experiments proved the trends that were set by simulations.
Children’s and Adolescents’ Pet Attachment, Empathy, and Compassionate Responding to Self and Others
Authors: Bosacki Sandra , Tardif-Williams Christine Yvette , Roma Renata P. S.
Published: November 2022

The research shows that children’s and adolescents’ attachments with pets play an important role in their social and emotional lives. However, little research exists on how children and adolescents show compassion toward themselves and others and how this caring ability relates to their attachment with pets. This study explored the relations among children’s and adolescents’ compassion, empathy, and attachment to their pets. Sixty-one Canadian youths aged 7–15.9 years (M = 11.35) participated in this study (n = 38 g, 23 b) and completed self-report questionnaires including the Lexington Attachment to Pets scale, subscale of Dispositional Positive Emotions, Self-compassion scale for children, and Bryant’s Index of Empathy for Children and Adolescents (IECA). The results showed older adolescents were more likely than younger children to score high on cognitive and emotional dimensions of empathy and be less likely to feel alone and isolated. High levels of emotional pet attachment related to high levels of the ability to feel sad when witnessing others in distress and high levels of mindful, compassionate, and self-responding feelings of compassion for others. The results also showed that those participants who experienced intensified emotional attachment toward their pets (either current or in the past), were less likely to judge themselves in negative ways. Overall, our findings suggest that children’s emotional attachments with pets relate to their ability to respond to themselves and others in kind and compassionate ways and not necessarily their ability to understand another person’s emotions.
Deciphering Depositional Environment of Playa Lakes Using Grain Size Parameters in the Arid and Semi-Arid Region of Rajasthan, India
Authors: Kumar Manish , Dashora Milap , Kumar Rajesh , Dubey Swatantra , Gupta Pankaj , Kumar Alok
Published: November 2022

This study encompasses the grain size distribution of the playa lakes (Pachpadra, Pokhran, and Didwana) of the Thar Desert in Rajasthan, India. The grain size of sediment particles is the most fundamental feature, giving essential information regarding their origin, transport history, and depositional conditions. The aeolian and fluvial transport processes were evaluated through environmentally sensitive grain size subpopulations to identify the differential sedimentary sources and dynamics in the playas. End-member modelling further determined the sediment grain size distribution through statistical analysis. The playa sediments mainly consist of very fine sand (46–54%) and very coarse silt (22–37%). The results show that the average fine fraction of Pachpadra, Pokhran, and Didwana playa was 46.29%, 66.11%, and 66.28%, respectively. In contrast, the average coarser fraction deposition in Pachpadra, Pokhran, and Didwana corresponds to 53.71%, 33.89%, and 33.72%, respectively. This suggests that the playas mostly contain aeolian sediment rather than fluvial sediment transported by dust/sand storms. Additionally, the textural pattern and depositional distribution of the sediments determined through the Passega CM diagram and bivariate plots indicate that 82% of the samples were poorly sorted, and 18% were very poorly sorted. Furthermore, an environmentally sensitive grain size component (ESGSC) was also assessed to identify the spatial variability and transport processes of sediment between these playas. Three ESGSCs in Pokhran (250 µ, 31 µ, and 2 µ) and Pachpadra (125 µ, 31 µ, and 4 µ), while two ESGSCs in Didwana playa (125 µ and 16 µ) were identified, indicating sediment deposition with moderate velocity in a low energy environment with a mixed sediment population transported by aeolian and fluvial activities.