bluuebunny/crossref_metadata_2025 huggingface dataset:
Os verbos ‘ter’ e ‘haver’: variação e mudança na língua portuguesa no Brasil
Authors: Baronas Joyce Elaine de Almeida , Macedo Rebeca Louzada
Published: September 2020

A língua, enquanto meio de interação social, participa da realidade humana modificando-se, constituindo novas formas e estruturas linguísticas do ambiente social. Estudos da Sociolinguística evidenciam a variação e as mudanças frequentes nas línguas. A partir desse viés teórico, o presente trabalho objetiva analisar a abordagem dos verbos ‘ter’ e ‘haver’ nas gramáticas normativas e descritivas. Para isto, foram analisadas as abordagens sobre esses verbos nas gramáticas de Rocha Lima (1974), Cunha (1982), Castilho (2010) e Perini (2010). O presente trabalho justifica-se pelo desejo de observar como as mudanças no uso desses verbos se refletiram nos compêndios gramaticais e, consequentemente, no ensino de Língua Portuguesa no Brasil. Dessa forma, a pesquisa caminhará entre os estudos sobre as mudanças linguísticas e a história do ensino de Língua Portuguesa no Brasil entrelaçada à concepção da língua enquanto fenômeno social e heterogêneo. Assim, a partir da realização desta pesquisa, foi possível verificar que, diferentemente das gramáticas normativas, as descritivas retratam as mudanças ocorridas no uso dos verbos ‘ter’  e ‘haver’.
Práticas de leitura no livro didático: a falta do prazer da leitura na formação do leitor
Authors: Rodrigues Paulo Cezar , Cardoso Rosimeiri Darc , Gonzaga Sílvia Regina Emiliano
Published: September 2020

Este artigo tem por objetivo investigar o modo como o livro didático (LD) de Língua Portuguesa (LP) propõe o trabalho com o ensino da leitura, analisando se este material apresenta leituras desvinculadas de atividades de estudo-interpretação do texto, denominadas de ‘leituras por prazer’ ou ‘fruição’, como estratégia de ensino para formação do leitor competente. Esta pesquisa fundamenta-se em estudos sobre leitura de Geraldi (1984), Eco (1986), Chartier (1994, 2001), Manguel (1997), Souza (1999) e Colomer (2007). O LD corpus da pesquisa é destinado ao 9º ano do Ensino Fundamental (EF), ‘Projeto Telaris: português’ (Borgatto, Bertin, & Marchezi, 2017). Os resultados demonstraram que, nas cinquenta e cinco propostas de leitura apresentadas na Unidade 1 desse manual, foram identificados ‘oito objetivos’ diferentes para a realização de leitura. Entretanto, dentre eles, não se verificou a presença de nenhuma proposta cujo objetivo fosse exclusivamente a fruição. Constatação preocupante, pois a leitura fruição, no LD, poderia servir como importante estratégia de ensino para a formação do leitor.
La comunicación unilateral en el síndrome de Asperger: la agilidad de turno y el índice de participación en los intercambios orales de niños con y sin déficit pragmático
Authors: Rodríguez Muñoz Francisco José , Muñoz Hernández Isabel Ofelia
Published: September 2020

La presente investigación pretende contribuir a la descripción del comportamiento comunicativo de niños con síndrome de Asperger (SA). Esta condición, que es incluida en el espectro autista, desde un punto de vista lingüístico, es concebida como un déficit pragmático primario. El estudio cuestiona la unilateralidad comunicativa que con frecuencia se les atribuye a estos hablantes comparando 40 muestras orales de niños con y sin SA. Así, se analizan cuantitativamente dos categorías: la ‘agilidad de turno’ y el ‘índice de participación’. Los resultados sugieren que ambos índices no presentan diferencias significativas, por lo que se ajustan a los valores normalizados. A pesar de los condicionantes contextuales, se concluye que no debería generalizarse la característica de unilateralidad al describir el estilo comunicativo de los niños con SA. Uno de los factores clave del que dependerá la unilateralidad en los intercambios comunicativos orales será el interés que les suscite a estos usuarios el tema que se trate.
Algumas notas sobre os livros infantis na hipermodernidade: O Polegarzinho ou As Botas de Sete Léguas numa seleção de livros-objeto para a infância
Authors: Martins Diana Maria Ferreira , Silva Sara Reis da
Published: September 2020

A dimensão morfológica, anatômica e material aufere, hoje, um especial relevo ao livro de recepção infantil, contrariamente à tradicional deferência atribuída à componente verbal, substantivada em objetos, não raras vezes, lúdicos, híbridos, originais que desafiam quaisquer tentativas de definição e categorização por parte da investigação. Tendo como referência central o volume Agradar e tocar: ensaio sobre a sociedade da sedução, de Gilles Lipovetsky, dedicado à destrinça dos pilares da sociedade hipermoderna, este estudo centra-se, particularmente, no conto O Polegarzinho ou As Botas de Sete Léguas, universalmente difundido desde 1697, por Charles Perrault, texto aqui revisitado em quatro livros-objeto dirigidos à infância, designadamente As Botas das Sete Léguas, de Vojtěch Kubašta; Polegarzinho e as Botas das Sete Léguas, ilustrado por Truus Vinger, ambos editados pela Electroliber; O Pequeno Polegar, da Booksmile, e O Muito Grande Pequeno Polegar, ilustrado por Clémentine Sourdais, traduzido pela Edicare. Pretende-se, deste modo, refletir sobre as principais singularidades destas obras ou destas reconfigurações verbo-icônicas e gráficas, baseadas sobretudo na exploração da materialidade do objeto-livro, por via da qual se revisita ao nível estético, sensorial ou, mesmo, lúdico uma narrativa centrada na temática da morte e do abandono infantil.
Type II Cytokines Fine-Tune Thymic T Cell Selection to Offset Murine Central Nervous System Autoimmunity
Authors: Barik Subhasis , Cattin-Roy Alexis N. , Ukah Tobechukwu K. , Miller Mindy M. , Teixeiro Emma , Zaghouani Habib
Published: September 2020

Early thymic progenitors (ETPs) are bone marrow–derived hematopoietic stem cells that remain multipotent and give rise to a variety of lineage-specific cells. Recently, we discovered a subset of murine ETPs that expresses the IL-4Rα/IL-13Rα1 heteroreceptor (HR) and commits only to the myeloid lineage. This is because IL-4/IL-13 signaling through the HR inhibits their T cell potential and enacts commitment of HR+ETPs to thymic resident CD11c+CD8α+ dendritic cells (DCs). In this study, we discovered that HR+-ETP–derived DCs function as APCs in the thymus and promote deletion of myelin-reactive T cells. Furthermore, this negative T cell selection function of HR+-ETP–derived DCs sustains protection against experimental allergic encephalomyelitis, a mouse model for human multiple sclerosis. These findings, while shedding light on the intricacies underlying ETP lineage commitment, reveal a novel, to our knowledge, function by which IL-4 and IL-13 cytokines condition thymic microenvironment to rheostat T cell selection and fine-tune central tolerance.
Thunderstorm-asthma, two cases observed in Northern Italy
Authors: Spina Maria Francesca , Banfi Paolo Innocente , Nicolini Antonello
Published: September 2020

Thunderstorm asthma is a rare event: in this letter we describe two cases observed during the same month of 2018 at an Italian Emergency department, assessed by the same medical team and according to the same methodology and approach. Given the infrequency of such a phenomenon and the debate around its nature, frequency, and - at times - existence, we strongly believe it is important for all specialists who observe such cases to report them, building an evidence base to expand its knowledge and understanding.
Genuine impact of 18F-fluorodeoxyglucose positron emission tomography with contrast-enhanced computed tomography in clinching the diagnosis and follow-up response assessment of vascular graft infections
Authors: Sivathapandi Thangalakshmi , Amalachandran Jaykanth , Elangovan Indirani , Simon Shelley , Patel Asra ,   Nikita
Published: September 2020

Vascular graft infection (VGI) is a rare and severe complication after vascular surgery associated with significant morbidity and mortality, but the diagnosis is not always straightforward due to its variable and nonspecific clinical signs. Computed tomography (CT) scan is considered to be the diagnostic tool of choice for advanced VGI, but there is a high incidence of false-negative results, especially in low-grade infections. 18F-Fluorodeoxyglucose positron emission tomography with contrast-enhanced CT (18F-FDG PET-CT) imaging can serve as an effective alternative tool for assessment of suspected VGI and also provide accurate anatomic localization of the infective focus. Here, we describe three cases of VGI with various clinical presentations where the site of infection was diagnosed, confirmed, and documented with the help of 18F-FDG PET-CT imaging.
Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case
Authors: Stolniceanu Cati , Grierosu Irena , Matovic Milovan , Stefanescu Cipriana
Published: September 2020

Gastrin-secreting tumors, hypergastrinemia and severe ulcer disease form the trademarks of Zollinger-Ellison syndrome (ZES). We report a case of gastrinoma, in a patient who was misdiagnosed for almost five years. The case emphsizes the the special role of functional imaging in the personalized approach to the patient with suggestive symptomatology for NETs. Taking into account that in 80 to 100% of cases of gastroenteropancreatic (GEP) NETs are expressing somatostatin receptors, the functional imaging with radiolabeled somatostatin analogues can be used in order to improve its diagnosis, respectively the treatment of GEP NETs. In the approach to the patient with tremendous digestive symptomatology, physicians from different specialties should evaluate NETs specific markers and then insist on structural-functional complementarity, avoiding the waste of time and high cost of repeated structural investigations. The conclusion of our study is that functional imaging is mandatory in the diagnostic algorithm of gastrinoma.
Extrapleural solitary fibrous tumor evidenced by 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography study in the staging of a high-risk prostate cancer patient
Authors: Braga Ribeiro André , Nascimento Thais , Lima Eduardo
Published: September 2020

Positron emission tomography/computed tomography (PET/CT) using 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) became an important tool in the prostate cancer (PC) diagnosis. Despite its high sensitivity and specificity, this method may produce false-positive findings, as indicated by previous studies. This case report aims to warn nuclear medicine physicians, oncologists, and urologists about the possibility of false-positive findings using this imaging modality, especially in patients who have already been diagnosed with other malignancies. A 69-year-old man, previously treated for an extrapleural solitary fibrous tumor (ESFT), underwent staging tests after a new diagnosis of high-risk PC. 68Ga-PSMA PET/CT imaging revealed an abnormal uptake in the prostate and in the right humerus. A biopsy was performed, and the pathology showed a lesion consisting of an ESFT metastasis. Diagnostic issues related to 68Ga-PSMA PET/CT imaging should be disseminated to help physicians make appropriate treatment choices for each patient and avoid unnecessary procedures.
Variable features of 18F-fluorodeoxyglucose positron emission tomography–computed tomography scan in anorectal malignant melanoma: Case reports and review articles
Authors: Shah Digish
Published: September 2020

Anorectal malignant melanoma (ARM) is a rare variant of malignant melanoma and even more rare among all anorectal cancers. 18F-fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (CT) scan is valuable in staging, restaging, treatment response evaluation, and long-term follow-up of malignant melanoma. Here, reporting two cases of anorectal melanoma with a variety of FDG uptake pattern and CT-based features and reviewed a few articles to evaluate the pattern of FDG uptake.
Oligometastasis to testis in prostate cancer: Role of gallium-68 prostate-specific membrane antigen positron-emission tomography computed tomography
Authors: Gupta Manoj , Choudhury Partha , Rawal Sudhir , Singh Amitabh
Published: September 2020

Accurate staging and restaging with early detection of recurrent site is the key for planning treatment in patients of prostate cancer. Recently, gallium-68 prostate-specific membrane antigen positron-emission tomography computed tomography (68Ga-PSMA PET/CT) has emerged as a better tool for this. Few uncommon sites of early metastasis can also be identified in addition to the other common sites. Herein, we present three cases of early metastasis to testis in prostate cancer identified on 68Ga-PSMA PET/CT scan.
Outcomes following I-131 treatment with cumulative dose exceeding or equal to 600 mCi in differentiated thyroid carcinoma patients
Authors: Kaewput Chalermrat , Pusuwan Pawana
Published: September 2020

To evaluate treatment outcomes following radioactive iodine (RAI) treatment with a cumulative dose of ≥≥600 mCi in differentiated thyroid carcinoma (DTC) patients, a retrospective review of medical records was done in 176 DTC patients with a cumulative dose of ≥600 mCi from January 1993 to December 2013. All patients were followed up for at least 2 years after receiving 600 mCi of I-131 treatment. Remission criteria were no clinical and imaging evidence of disease and low serum thyroglobulin levels during thyroid-stimulating hormone suppression of <0.2 ng/ml or of <1 ng/ml after stimulation in the absence of interfering antibodies. A total of 176 patients were included in the study: 137 – papillary thyroid cancer, 29 – follicular thyroid cancer, 9 – mixed papillary and follicular thyroid cancer, and 1 – Hurthle cell carcinoma. Most of the patients (118, 67%) had locoregional metastasis, whereas 48 patients (27%) had distant metastases at presentation. The median cumulative dose was 900 mCi (range: 600–2200 mCi). The mean follow-up period was 82.84 ± 42.41 months. Only 16 patients (9.1%) met remission criteria at the end of treatment. The rest of patients (160, 90.9%) were not remitted: stable disease in 94 (53.4%), at least 1 metastasis without I-131 uptake in 34 (19.3%), progressive disease in 21 (11.9%), and death during the whole follow-up period in 11 (6.3%). Two patients (1.1%) developed second primary malignancy. Eighteen cases were suspected of bone marrow suppression (14 cases [7.9%] had anemia and 5 cases [2.8%] had neutropenia). Seven patients (3.9%) developed permanent salivary gland dysfunction. Although the complications after receiving RAI treatment with a cumulative dose of ≥≥600 mCi were low and not severe, the patients with remission were in <10%. Our study suggests that the decision to administer further treatments should be made on an individual basis because beneficial effects may be controversial.
Diagnostic value of sentinel lymph node scintigraphy and 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in the detection of metastatic lymph nodes in patients with early-stage cervical cancer
Authors: Reyneke Florette , Snyman Leon , Lawal Ismaheel , Lengana Thabo , Vorster Mariza , Sathekge Mike
Published: September 2020

Cervical cancer is staged clinically using the International Federation of Gynaecology and Obstetrics staging system. Although lymph node status does not form part of the staging, it has important prognostic and potential therapeutic implications. The aim of the study was to evaluate the role of sentinel lymph node (SLN) scintigraphy and 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in detecting lymph node metastases in patients with early-stage cervical cancer. Thirty-six patients with early-stage cervical cancer underwent SLN detection during primary operation. Of the 36 patients, 28 patients underwent 18F-FDG PET/CT before surgery. The 18F-FDG PET/CT images were analyzed with the histopathological findings as the reference standard. The diagnostic performance of 18F-FDG PET/CT in the detection of nodal disease was reported in terms of accuracy value. The SLN detection rate was the highest (91.7%) using the combined method (lymphoscintigraphy, intraoperative gamma probe, and blue dye). Seven of the thirty-six patients had lymph node involvement (19.4%), of which five had preoperative 18F-FDG PET/CT imaging. On overall patient-based analysis, the sensitivity, specificity, positive predictive value, negative predictive value (NPV), and accuracy of 18F-FDG PET/CT were 40.0%, 78.3%, 28.6%, 85.7%, and 71.4%, respectively. The combination of radiolabeled nanocolloid with blue dye is safe and reliable and allows successful detection of SLNs in patients with early-stage cervical cancer in a population with high prevalence of human immunodeficiency virus. The specificity and NPV of 18F-FDG PET/CT are high and can be used in conjunction with SLN biopsy.
Benign uptake of 18F-fluorodeoxyglucose in the gallbladder on positron emission tomography-computed tomography
Authors: Hussain Riffat , Nausheen Sadaf , Ahmed Naveed , Mahmood Tariq
Published: September 2020

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been established as the indisputable tool in the oncological arena to diagnose, stage/restage, and report treatment response for various tumor malignancies. FDG uptake mostly identifies pathological uptake in oncological scans with the tracer on PET studies; however, benign uptakes are also commonly seen. Reported here is a benign case of increased uptake of the FDG on a PET with computed tomography scan in the gallbladder (GB) of a patient being screened for a known carcinoma breast. The benign accumulation of the tracer is seen in the GB to various degrees and this phenomenon may occur as a result of FDG excretion into the bile. When interpreting clinical PET images, recognition of this phenomenon is important to avoid misdiagnosing physiological GB FDG uptake as pathological so as to avoid misinterpretations of the findings.
Diagnosis of portal vein tumor thrombosis in colorectal carcinoma in fluorodeoxyglucose positron emission tomography—computed tomography scan and its clinical implication
Authors: Shah Digish
Published: September 2020

Hypercoagulable state is seldom associated with colorectal carcinoma either in the form of bland thrombosis or tumor thrombosis (TT). Venous TT should not be overlooked while deciding treatment of colorectal cancer due to its propensity to complicate the disease in terms of morbidity and mortality even in favorable prognostic case of colorectal cancer. Fluorodeoxyglucose positron emission tomography—contrast-enhanced computed tomography (FDG PET-CECT) scan has proven its role in staging of colorectal cancer and also to diagnose tumor venous thrombosis. Here, we are presenting a case of a 61-year-old male patient having adenocarcinoma of rectosigmoid colon, and on pretherapy FDG PET-CECT scan, he was found with portal vein TT and its related complication which is helpful for staging, treatment planning, and prognostication.
An Artemia franciscana bioassay for the monitoring of lipophilic phycotoxins in marine bivalve mollusc cultures: An alternative to screening testing?
Authors: Guaralde Alailton Dos Reis , Souza Daniela Almeida de , Guimarães Júnior Celso Luiz Possas , Guimarães Rafael Soares , Saraiva Victor Barbosa , Silva José Augusto Ferreira da , Murata Marcos Massao , Lopes Renato Matos , Hauser-Davis Rachel Ann , Oliveira Manildo Marcião de
Published: September 2020

In Brazil, malacoculture is developed mainly in the state of Santa Catarina, followed by São Paulo and Rio de Janeiro. In the course of the development of Brazilian mariculture, legislation has addressed the sanitary requirements necessary for bivalve commercialization. However, monitoring phycotoxins is a challenge, due to often costly reference methods. In this context, this study evaluated the use of alternative ecotoxicological and bioanalytical methods using Artemia franciscana (brine shrimp) lethality assessments. The results confirm that, although correlations between the reference mouse assay and the brine shrimp assays were not high, the alternative brine shrimp assay may be incorporated into phycotoxin monitoring programs, as hepatopancreas methanolic extracts of mussel (Perna perna) containing DSP resulted in high lethality rates. Therefore, further methodological adjustment studies and the inclusion of other enzymatic and toxicological models are required to further assess these differences, and associations between ecotoxicological methods as early-alarm methods are encouraged.
Connecting East and West through Modern Confucian Thought
Authors: Ali Forkan
Published: September 2020

This study is an attempt to establish that 20th century’s canonized Taiwanese philosopher Mou Zongsan (1909–1995) has contributed significantly to the innovative burgeoning of modern Confucianism (or New Confucianism) with the revision of Western philosophy. This is based on the hypothesis that if ideas travel through the past to the present, and vice versa, and if intellectual thinking never knows any national, cultural and social boundaries, then there is an obvious intersection and communication of philosophical thoughts of East and West. This article also contemplates the fact that Western philosophies are widely known as they are widely published, read and circulated. Conversely, due to the language barriers philosophy and philosophers from the East are less widely known. Therefore, this research critically introduces and connects the early 20th century Confucian philosopher Shili Xiong (1885–1968), his disciple the contemporary Taiwanese Confucian intellectual Mou Zongsan, along with the Western philosophers Immanuel Kant (1724–1804), Martin Heidegger (1889–1976), and Herman Bavinck (1854–1921), through ideas like moral autonomy, ethics, ontology, and imago Dei. In so doing, the article delineates the path to study 20th century Taiwanese philosophy, or broadly Chinese Confucian philosophy which makes a bridge between the East and the West through Modern Confucianism prevalently called New Confucianism.
Vaginal Fibroma Presenting as a Paraurethral Mass Mimicking Cystocele: A case report
Authors: Bharati Sonu , Ganesh Danagl  , Shrestha Ranjana , Karki Aruna , Pradhan Hema Kumari , Bhattachan Kabin , Kunwar Ashok , Bajracharya Nishma , Tiwari Kenusha Devi , Maharjan Sunita
Published: September 2020

Benign female paraurethral lesion encompasses a spectrum of entities that have significance in clinical urology. Fibromas are usually present in the uterus originating from the smooth muscles,however,vaginal fibroma is the extra uterine manifestation of leiomyoma. Here, we present a case of 45 years oldperimenopausalfemale, Para 6, living issues 6 who presented at our out-patientsdepartmentwith the complaint of mass growing in the vagina for 5 years but has increased in size for last 2 years. It has been associated with urinary symptoms, bleeding from mass and dyspareunia. General physical examinations were normal but on local examination mass arising from anterior vaginal wall mimicking cystocele  with normal appearing external urethral meatus . However, her basic investigations including cystoscopy were normal. The tumor was surgically removed via myomectomy and its histopathology showed benign fibroma.
PERUBAHAN PAON PADA RUMAH TRADISIONAL DI DESA BATUAN SUKAWATI
Authors: Putra Putu Arya Wiastina , Yulianasari Anak Agung Ayu Sri Ratih
Published: September 2020

Bali is an area famous for its million beauty and charm. The beauty of nature, the hospitality of the people and the sublime Customs and Culture are very valuable assets for Bali in particular and Indonesia in general. Of all the beauty and uniqueness, one thing that is important to note is about Balinese Traditional Architecture which is based on culture and breathes Hinduism. In the study of the construction of Balinese buildings, especially Paon or kitchens, this was carried out to understand more deeply some of the traditional Balinese architectural knowledge that approaches the truth, the direction of development, and the high noble values of our ancestral heritage to be strong and strong. a research was conducted on what changes occurred in the Paon building in the village of Batuan, Sukawati. So that it can be expressed to add to the nation's cultural treasury as a material for information and a comprehensive picture for the Balinese people in particular. The formulation of the problem raised is: How does Paon change in a traditional house in Batuan Village, Sukawati. This study uses an inductive approach to the concept formulated from several elements including: field observations and interviews with experts / experts. It can be concluded: The shape of the Paon building has not changed, but only in terms of materials have changed over time, such as the use of roof covering materials, which all use reeds to become tiles.
PUSAT PEMBINAAN DAN PENGEMBANGAN KESENIAN WAYANG DI BALI
Authors: Budiarta I Wayan , Tri Adiputra I Gusti Ngurah
Published: September 2020

The existence of some puppets show in Bali are significantly marginalized  at recently in  the midst of any entertaiments growing up. There are a tendency that the puppets show are almoust going to be extinct, for an example Nongnong Kling Puppet at Paksa Bali Village, Klungkung regency. The sacred puppet show was able to be performed until 1988, because  its group members are dispersed and there is only one senior dancer still remains. The similar condition was happened at custom village of Manggis, Manggis subdistrik at Karangasem regency.  The village had ever possesed   a Telek Puppet group  at  (Wayang Wong/Parwa) as a sacred dance for offering rites/piodalan the Pura Desa temple of Manggis custom village. Waning of the dance was caused by the lack interest of the successor generations (the youth prefer to work on tourism). Meanwhile, at  Buduk custom village, Badung regency, there is a Cupak  puppet tradition group  that is closed to be vanished. Regarding with the extinction tendency of the puppet show group, so it needs establishing a  facility as the centre for puppet coaching and developing in Bali.  The research  uses an inductive approach for constructing some concepts of designing and planning. The concepts were formulated from the intesection of some components, such as :  the field observation result, the puppet expertise interview, the study of literatures , the comparative study, the study of some architectural standards and also the study of local government regulation. The designing and planning for the centre of puppet coaching and developing in Bali, in Gianyar regency,  are used the basic concept as follwos :  recreative, educative, creative and productive which means that the concepts  are reformulated from : the functional approach, climate & environment and the social-cultural background. The architecture theme of Neo Vernacular applied  in designing and planning for the centre of puppet coaching and developing in Bali, in Gianyar regency intend its façade/physical appearance can be in harmonious matter  at the surrondings,  but it still has a contemporary building impression. Because the Neo Vernacular architecture is an equivalent combination between the traditional architecture and modern one.
On truncated Poisson exponential proportional hazard model
Authors: JAMEE AHSAN RAHMAN , BARI WASIMUL
Published: September 2020

Classical survival regression models may provide misleading results when event of interest occurs due to more than one causes. In this paper, taking all possible causes for the occurrence of event into account, a Truncated Poisson Exponential survival proportional hazard model has been proposed. An extensive simulation study has been conducted to examine the performance of the proposed survival model in the absence and presence of covariates under different percentages of censoring. The simulation results reveal that estimators of the regression parameters are consistent and efﬁcient. To illustrate the model, under–ﬁve child survival data extracted from Bangladesh Demographic and Health Survey 2014 have been used.
MEDIA PEMBELAJARAN KITAB TIJAN DIGITAL BERBASIS MULTIMEDIA
Authors: Malik Ferry Bastian , Supriatna Ade
Published: September 2020

Media Pembelajaran Kitab Tijan Digital merupakan aplikasi berbasis komputer yang membahas tentang ilmu tauhid. Ilmu tauhid adalah ilmu yang mengajarkan keesaan Allah taÃ¡la. Media Pembelajaran ini dibuat dan dikemas multimedia yang menarik agar para santri lebih tertarik untuk belajar buku tijan. Aplikasi Media Pembelajaran buku digital menggunakan bahasa arab-sunda. Aplikasi ini sangat mudah digunakan dan dapat dipahami oleh para santri pada saat pembelajaran. Media Pembelajaran ini merupakan media pembelajaran konvensional yang menjadi pembelajaran berbasis multimedia.Metode pengembangan perangkat lunak yang digunakan dalam pengembangan dan pembuatan perangkat lunak ini adalah dengan menggunakan pemodelan berorientasi objek dengan Unifield Modeling Language (UML) dan alat-alat yang digunakan di guna menggunakan diagram kasus, kasus penggunaan, diagram aktivitas, diagram kelas, diagram urutan dan diagram penempatan. Perangkat yang digunakan untuk membuat aplikasi ini menggunakan bahasa pemograman Delphi 7.
SISTEM MONITORING KUALITAS AIR MINERAL BERBASIS IOT (INTERNET OF THINGS) MENGGUNAKAN PLATFORM NODE-RED DAN METODE SAW (SIMPLE ADDITIVE WEIGHTING)
Authors: Wijaya Anderias Eko , Sukarni Rijal Bani Salam
Published: September 2020

Air merupakan zat yang paling penting dalam kehidupan setelah udara. Kecenderungan penggunaan air minum ulang oleh masyarakat di semakin meningkat, salah satu penyebabnya adalah pencemaran udara yang semakin parah hingga saat ini. Namun, sering kali masyarakat memperhatikan kualitas dan standarisasi tentang keamanan air minum isi ulang yang mereka konsumsi yang diproduksi oleh depot. Dengan menggunakan metode SAW kita dapat menyusun mineral udara dari depot sehingga memudahkan konsumen dalam memilah dan memilih kualitas air mineral tersebut. Dan dengan adanya IoT yang digunakan dalam sistem ini dapat meningkatkan akurasi dan kecepatan dalam pengambilan data dan kesimpulan, sehingga memberikan referensi pada konsumen untuk memilih depot air mineral yang berkualitas cepat dan tepat. Alat mengambil data dengan sensor pH, Kekeruhan, dan TDS Meter untuk mencari tingkat keasaman dan kebasaan pada udara, udara kekeruhan, dan padatan terlarut dalam udara. Kemudian data yang diperoleh dikirim melalui jaringan MQTT Broker ke platform node-red, data yang ditampilkan di inputkan ke dalam database untuk diolah menggunakan metode SAW, hasil perhitungan metode SAW dibeli oleh sistem. alat dan sistem ini dapat diimplementasikan pada Dinas Kesehatan untuk mengimplementasikan kualitas air mineral yang dijulal oleh Depot Air Minum Isi Ulang. Kata Kunci: Arduino Uno, Internet of Things, Simple Additive Weighting data yang ditampilkan di inputkan ke dalam database untuk diolah menggunakan metode SAW, hasil perhitungan metode SAW pembayaran oleh sistem. alat dan sistem ini dapat diimplementasikan pada Dinas Kesehatan untuk mengimplementasikan kualitas air mineral yang dijulal oleh Depot Air Minum Isi Ulang. Kata Kunci: Arduino Uno, Internet of Things, Simple Additive Weighting data yang ditampilkan di inputkan ke dalam database untuk diolah menggunakan metode SAW, hasil perhitungan metode SAW pembayaran oleh sistem. alat dan sistem ini dapat diimplementasikan pada Dinas Kesehatan untuk mengimplementasikan kualitas air mineral yang dijulal oleh Depot Air Minum Isi Ulang.
Diabetes Mellitus and Prediabetes among Patients with Tuberculosis in a Single North Indian Tertiary Care Centre
Authors: Kodiatte Abraham , John Mary , Jacob Jubbin Jagan
Published: September 2020

Background

Prevalence of diabetes mellitus (DM), though believed to be high among patients with tuberculosis (TB), remains unclear for the want of systematic studies and unequivocal methods of diagnosing DM. This study was done to determine the prevalence of prediabetes and DM in adult patients with TB.

Methods

This prospective study of one year's duration, carried out at a tertiary care centre included 313 consecutive adult patients diagnosed (either microbiologically, histologically or based on clinical presentation) with pulmonary or extrapulmonary TB. Those without a history of pre-existing DM were subjected to oral glucose tolerance test (OGTT) with 75 g glucose.

Results

In this cohort 85 (27%) patients had pre-existing DM. The remaining 228 patients not diagnosed earlier with DM underwent a 75 g OGTT, of which 63 (28%) were found to have newly detected prediabetes (impaired fasting glucose [IFG] and impaired glucose tolerance [IGT] alone in 36 and 10 patients respectively and both IFG and IGT in a further 17) and DM was diagnosed in 9 (4%) patients (fasting blood glucose [FBG] ≥ 126 mg/dl in 1 and both FBG ≥ 126 mg/dl and 2-h plasma blood glucose [PLBG] ≥ 200 mg/dl in 8 patients). The total prevalence of (newly diagnosed) DM and prediabetes, therefore, was 32% (72 patients); the overall prevalence of DM was 30% (94 patients).

Conclusions

This study found high prevalence of prediabetes and diabetes among patients with TB. This underscores the need for a bidirectional screening strategy to improve diagnosis and outcome of both TB and DM.
Tenofovir-Induced Delayed Nephro-Osteo Toxicity
Authors: Kumar Bhargavi , Prabhakar Rajgokul , Thangavelu Saravanan
Published: September 2020

Tenofovir disoproxil fumarate (TDF) is the foundation nucleotide reverse-transcriptase inhibitor in the recommended first-line regimen for all naive human immunodeficiency virus-1 (HIV-1) patients whose age is more than 10 years and body weight is more than 30 kg. Although it has a good safety profile overall, nephrotoxicity is a concern and its overall incidence is 1-6% with a long period of clinical latency. Nephrotoxicity may manifest as either proximal renal tubule dysfunction in the form of a partial or complete Fanconi syndrome or as decreased renal function leading to acute or chronic kidney injury. Osteomalacia can also develop secondary to complicating hypophosphataemia and low calcitriol levels. Here we report a 50-year-old HIV-positive male on tenofovir who presented with proximal renal tubular acidosis and fracture of left neck of femur four years after initiation of the drug.
Winslow Pathway Collaterals: An Unusual Arterial Network in Takayasu Arteritis
Authors: Gururani Subodh , Sreesailam Sreejitha K , Narayanan Ramakrishna , Devarasetti Phani K , Rajasekhar Liza
Published: September 2020

Takayasu arteritis which is reported more commonly from Asia and in females can present as middle aortic syndrome with lower limb claudication. We present a case of a young male with Takayasu arteritis with middle aortic syndrome and Winslow pathway collaterals with lower limb ischaemia, hypertension, coronary occlusion and stroke. The extensive collateral formation was visible as a clinical finding over the abdominal wall. The identification of these collateral pathways is essential in understanding the extent of haemodynamically significant disease and it alerts to the possibility of surgical injury during procedures like laparotomy or harvesting of internal thoracic artery for coronary artery bypass graft.
Uncommon Simultaneous Diagnosis of Multiple Myeloma and Chronic Myeloid Leukaemia
Authors: Vishal Mangal , Paresh Singhal , Adwait Sodani , Nachiketa
Published: September 2020

Chronic myeloid leukaemia (CML) is a clonal hematopoietic stem cell disorder. The annual incidence of CML is 1.5 cases per 100,000 individuals. Multiple myeloma (MM) represents a malignant proliferation of plasma cells derived from a single clone. The co-occurrence of two rare malignancies CML and MM in the same patient is an extremely rare incident, and simultaneous diagnosis of CML and MM is reported in only five cases in the literature. A 75-year-old male presented with complaints of easy fatigability, loss of appetite and unquantified weight loss of four months’ duration. On evaluation he was found to have normocytic normochromic anaemia, leucocytosis, elevated serum-calcium concentration and azotaemia. Peripheral blood for the BCR-ABL fusion gene product was positive by fluorescence in situ hybridisation (FISH). However, bone marrow biopsy revealed CD138 positive, 15% plasma cells. Thus the diagnosis of CML and MM was established. Although we can't be certain regarding the cause of CML and MM in our patient, the hypothesis that they evolved from common malignant pluripotent hematopoietic stem cells still holds. However, at the age of 75 years, it might be just due to chance.
Usefulness of a Workshop on Scientific Writing and Publication in Improving the Baseline Knowledge Deficit among Postgraduates
Authors: Goyal Mohit , Dua Amit , Kedia Arun Kumar , Misra Durga Prasanna , Santhanam Sham , Ravindran Vinod
Published: September 2020

Background

A well-written manuscript published in a reputable journal is the deserved end-point of good research. It is important for postgraduates to be trained in scientific writing for their academic progression as well as the advancement of science.

Methods

A day-long workshop on scientific writing and publication was conducted at Raipur, India in February 2020. The medical postgraduate (UK equivalent: Core Medical Trainee) participants were engaged with lectures, discussions and a practical session requiring critical appraisal of a manuscript. The lectures also discussed publication ethics and the perils of falling prey to predatory journals. Pre and post-workshop surveys were given to the participants to assess the impact of the workshop on the baseline knowledge of scientific writing and publishing.

Results

Out of 69 participants, there were 67 (response rate 97%) and 41 (response rate 59%) respondents to the pre and post-workshop surveys respectively. The former identified a lack of baseline knowledge ranging from 6% for determining the components of the individual sections of the manuscript such as Introduction or Methods, 40% for the use of acronyms, and 55% for knowledge of different referencing styles, to 61% for knowledge of indexing agencies. The post-workshop survey revealed improvement in participants’ knowledge of the contents of various sections of the manuscript and their knowledge about referencing styles and indexing agencies. In the post-workshop survey, 20% of respondents said that they would be open to engaging with predatory journals, which underscored the need to educate them continuously regarding the demerits of such practice. Participants expressed the need for longer workshops, preferably spread over two days, with discussion on research methodology and statistical analysis, and more ‘hands-on’ sessions.

Conclusion

This survey underscores the need for structured training in scientific writing. Its inclusion in the medical postgraduate curriculum appears desirable.
Rcpe Symposium – Medicine of the Older Person
Authors: Jayasuriya Purnima
Published: September 2020

The Medicine of the Older Person symposium was held on Thursday 19 March 2020 at the Royal College of Physicians of Edinburgh.
Sound Design for Moving Image
Authors: Scott-James Kahra
Published: September 2020

Sound Design for Moving Image offers a clear introduction to sound design theory and practice to help you integrate sound ideas into your productions. Contemporary soundtracks are often made up of hundreds of separate tracks, and thousands of individual sounds, including elements of dialogue, music and sound effects. As a result, many budding filmmakers find them a daunting prospect, and are tempted to leave sound to the last stages of post-production. This book, from award-winning Sound Designer Kahra Scott-James, encourages you to incorporate sound into your pre-production planning, to make the most of this powerful narrative tool.

Adopting a specific framework in order to help demystify sound design for moving image, the book isn't designed as a sound engineering handbook, but as a guide for moving image content creators wanting to explore sound and collaborate with sound designers. Regardless of medium, the same, or similar concepts can be adopted, adapted, and applied to any project employing sound.

Includes detailed and insightful interviews with leading sound designers, including Randy Thom, Director of Sound Design at Skywalker Sound, and Glenn Kiser, Director of the Dolby Institute, as well as practical projects to help you hone your skills using video and sound files available from the companion website -https://www.bloomsbury.com/cw/sound-design-for-moving-image
- making this is a complete sound course to take you from novice skills to confident practitioner.
Post Sound Design
Authors: Avarese John
Published: September 2020

Post Sound Design provides a practical introduction to the fascinating craft of editing and replacing dialog, creating Foley and sound effects, editing music, and balancing these elements to a final mix. Based on years of experience and teaching this material to students at Drexel University, award-winning film composer John Avarese offers user-friendly knowledge and stimulating exercises to help compose story, develop characters, and create emotion through skillful creation of the sound-track. Starting each chapter with a real-life example, the textbook is structured in such a way as to create a fundamental understanding of the physics and the biological foundation of hearing, and put it into practice with suggested movie scenes demonstrating the discussed audio techniques. Post Sound Design engagingly demonstrates the individual areas essential to creating a soundtrack that will enhance any media production.
Stratospheric carbon isotope fractionation and tropospheric histories of CFC-11, CFC-12 and CFC-113 isotopologues
Authors: Thomas Max , Laube Johannes C. , Kaiser Jan , Allin Samuel , Martinerie Patricia , Mulvaney Robert , Ridley Anna , Röckmann Thomas , Sturges William T. , Witrant Emmanuel
Published: September 2020

Abstract. We present novel measurements of the carbon isotope composition of CFC-11 (CCl3F), CFC-12 (CCl2F2), and CFC-113 (CF2ClCFCl2), three atmospheric trace gases that are important for both stratospheric ozone depletion and global warming. These measurements were carried out on air samples collected in the stratosphere – the main sink region for these gases – and on air extracted from deep polar firn snow. We quantify, for the first time, the apparent isotopic fractionation, εapp(13C), for these gases as they are destroyed in the high- and mid-latitude stratosphere: εapp(CFC-12, high-lat) = (−20.2 ± 4.4) ‰ and εapp(CFC-113, high-lat) = (−9.4 ± 4.4) ‰, εapp(CFC-12, mid-lat) = (−30.3 ± 10.7) ‰, and εapp(CFC-113, mid-lat) = (−34.4 ± 9.8) ‰. Our CFC-11 measurements were not sufficient to calculate εapp(CFC-11) so we instead used previously reported photolytic fractionation for CFC-11 and CFC-12 to scale our εapp(CFC-12), resulting in εapp(CFC-11, high-lat) = (−7.8 ± 1.7) ‰ and εapp(CFC-11, mid-lat) = (−11.7 ± 4.2) ‰. Measurements of firn air were used to construct histories of the tropospheric isotopic composition, δT(13C), for CFC-11 (1950s to 2009), CFC-12 (1950s to 2009), and CFC-113 (1970s to 2009) – with δT(13C) increasing for each gas. We used εapp(high-lat), which were derived from more data, and a constant isotopic composition of emissions, δE(13C), to model δT(13C, CFC-11), δT(13C, CFC-12), and δT(13C, CFC-113). For CFC-11 and CFC-12, modelled δT(13C) was consistent with measured δT(13C) for the entire period covered by the measurements, suggesting no dramatic change in δE(13C, CFC-11) or δE(13C, CFC-12) has occurred since the 1950s. For CFC-113, our modelled δT(13C, CFC-113) did not agree with our measurements earlier than 1980. While this discrepancy may be indicative of a change in δE(13C, CFC-113), it is premature to assign one. Our modelling predicts increasing δT(13C, CFC-11), δT(13C, CFC-12), and δT(13C, CFC-113) into the future. We investigated the effect of recently reported new CFC-11 emissions on background δT(13C, CFC-11) by fixing model emissions after 2012, and comparing δT(13C, CFC-11) in this scenario to the model base case. The difference in δT(13C, CFC-11) between these scenarios was 1.4 ‰ in 2050. This difference is smaller than our model uncertainty envelope and would therefore require improved modelling and measurement precision, as well as better quantified isotopic source compositions, to detect.
Geodetic point surface mass balances: A new approach to determine point surface mass balances from remote sensing measurements
Authors: Vincent Christian , Cusicanqui Diego , Jourdain Bruno , Laarman Olivier , Six Delphine , Gilbert Adrien , Walpersdorf Andrea , Rabatel Antoine , Piard Luc , Gimbert Florent , Gagliardini Olivier , Peyaud Vincent , Arnaud Laurent , Thibert Emmanuel , Brun Fanny , Nanni Ugo
Published: September 2020

Abstract. Mass balance observations are very useful to assess climate change in different regions of the world. As opposed to glacier-wide mass balances, which are influenced by the dynamic response of each glacier, point mass-balances provide a direct climatic signal that depends on surface accumulation and ablation only. Unfortunately, major efforts are required to conduct in situ measurements on glaciers. Here, we propose a new approach that determines point surface mass balances from remote sensing observations. We call this balance the geodetic point surface mass balance. From observations and modelling performed on Argentière and Mer de Glace glaciers over the last decade, we show that the vertical ice flow velocity changes are small in areas of low bedrock slope. Therefore, assuming constant vertical velocities in time for such areas and provided that the vertical velocities have been measured for at least one year in the past, our method can be used to reconstruct annual point surface mass balances from surface elevations and horizontal velocities alone. We demonstrate that the annual point surface mass balances can be reconstructed with an accuracy of about 0.3 m w.e. a−1 using the vertical velocities observed over the previous years and data from Unmanned Aerial Vehicle images. Given the recent improvements of satellite sensors, it should be possible to apply this method to high spatial resolution satellite images as well.
Bernárdez Rodal, Asunción (2018). Soft Power: heroínas y muñecas en la cultura mediática. Madrid: Editorial Fundamentos.
Authors: Padilla Castillo Graciela
Published: September 2020

Reseña del libro de Bernárdez Rodal, Asunción (2018). Soft Power: heroínas y muñecas en la cultura mediática. Madrid: Editorial Fundamentos.
La pantalla superpuesta: inclusión de la interfaz en los videojuegos Her Story, Replica y Sara Is Missing
Authors: Moreira Alonso Joaquín
Published: September 2020

En este artículo se estudian tres videojuegos recientes en los que el Personaje-Jugador (PJ) debe resolver un misterio usando una interfaz muy semejante a la que está usando el jugador para jugar al juego. Se propone que la relación de semejanza entre las interfaces en la que se basa la superposición llama la atención sobre la relación de contigüidad entre el usuario y el dispositivo, contigüidad en la que es constituida la interfaz como unidad hermenéutica. Finalmente, se sugiere que no deberíamos pensar en el juego y el jugador como dos cosas separadas sino como un todo construido en el acto de jugar.
Las caras del soul: géneros musicales e imaginarios dinámicos
Authors: Pedro Josep , Gutiérrez-Martínez Begoña
Published: September 2020

En este artículo estudiamos los géneros discursivos a partir de su relación con la música popular. Desde una perspectiva pragmática, abordamos la evolución histórica del soul en relación al movimiento afroamericano por los derechos civiles. Con el objetivo de examinar las transformaciones del género y su imaginario entre las décadas de 1960 y 1970, realizamos un análisis socio-semiótico a partir de dos ejemplos paradigmáticos: la canción “Dancing in the Street” (Martha Reeves & The Vandellas, 1964) y el disco What’s Going On (Marvin Gaye, 1971). Estas obras concretan y figurativizan un imaginario dinámico que cambia en relación con la experiencia social y política de la comunidad afroamericana en EE.UU. Asistimos a la puesta en escena de las caras del soul: una alegre y esperanzada; otra herida y melancólica.