bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-invasive treatment in the management of Peyronie’s disease
Authors: Randhawa Karen , Shukla C. J.
Published: February 2019

Peyronies disease (PD) is estimated to affect approximately 3–9% of men worldwide and maybe associated with pain, erectile dysfunction and penile deformity including shortening. The condition has significant debilitating effects on quality of life, self-esteem and psychological wellbeing in addition to sexual function. Surgical results add further to this by patients having dissatisfaction with various aspects of outcomes. Non-surgical management may allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes. Several non-surgical options are currently being employed in the treatment of PD that may reduce or stabilize both objective measures (e.g. penile length and deformity) and subjective measures (including sexual function, pain and partner satisfaction). Nonsurgical management can allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes. In this article we explore the current non-surgical management options for PD including oral, mechanical therapies, intralesional and topical treatments. We also briefly discuss future treatment options in the form of stem cell therapy.
The Impact of the Physical Environment on Intrapartum Maternity Care: Identification of Eight Crucial Building Spaces
Authors: Setola Nicoletta , Naldi Eletta , Cocina Grazia Giulia , Eide Liv Bodil , Iannuzzi Laura , Daly Deirdre
Published: February 2019

Objectives, Purpose, or Aim:

This article investigates whether the physical environment in which childbirth occurs impacts the intrapartum intervention rates and how this might happen. The study explores the spatial physical characteristics that can support the design of spaces to promote the health and well-being of women, their supporters, and maternity care professionals.

Background:

Medical interventions during childbirth have consequences for the health of women and babies in the immediate and long term. The increase in interventions is multifactorial and may be influenced by the model of care adopted, the relationships between caregivers and the organizational culture, which is made up of many factors, including the built environment. In the field of birth architecture research, there is a gap in the description of the physical characteristics of birth environments that impact users’ health.

Method:

A scoping review on the topic was performed to understand the direct and indirect impacts of the physical environment on birth intervention rates.

Results and Discussion:

The findings are organized into three tables reporting the influence that the physical characteristics of a space might have on people’s behaviors, experiences, practices and birth health outcomes. Eight building spaces that require further investigation and research were highlighted: unit layout configuration, midwives’ hub/desk, social room, birth philosophy vectors, configuration of the birth room, size and shape of the birth room, filter, and sensory elements.

Conclusions:

The findings show the importance of considering the physical environment in maternity care and that further interdisciplinary studies focused on architectural design are needed to enrich the knowledge and evidence on this topic and to develop accurate recommendations for designers.
An Identity Control Theory Approach to Managing Career Identity in Emerging Adults
Authors: Sheppard Samantha , Hood Michelle , Creed Peter A.
Published: February 2019

Emerging adulthood provides an extended period during which potential career identities can be explored and feedback obtained before making a commitment. We tested an identity control theory model of the self-regulatory responses that emerging adults might make to negative feedback regarding their career identity. We surveyed 335 Australian emerging adults (mean age 19.28 years; 64% male) on negative career-related feedback, career-related goal discrepancy, career-related distress, career exploration, and identity defense. Consistent with theory, we found that more negative feedback was associated with greater perceived discrepancy between career goals and progress being made, which, in turn, was associated with greater distress. Distress was related to self-regulatory outcomes of identity defense and career exploration. The relationship was stronger for identity defense than for exploration. While defending might enable the current identity standard to be preserved, it might not be the most suitable response when the career goals are unsuitable or unobtainable.
Curriculum Redesign to Build the Moral Courage Values of Accelerated Bachelor’s Degree Nursing Students
Authors: DeSimone Barbara B.
Published: February 2019

The increasing complexities of health care coupled with the decreasing importance of ethical values held by college students, including nursing students, compel nurse educators to step up efforts to strengthen the moral courage values of their students. While the nursing curriculum is the ideal breeding ground for building moral courage values, few studies describe how these values were embedded in any nursing curriculum, much less an accelerated bachelor’s degree in nursing (ABSN) curriculum. This study outlines an ABSN curriculum with teaching-learning activities designed to build moral courage values in its classroom and clinical settings. Faculty perceptions of 29 ABSN students’ honesty, respectfulness, responsibility, fairness, and compassion were surveyed 4 weeks after beginning, and again at the end of the ABSN program. The ABSN exit questionnaire administered annually by the College Office of Institutional Research, assessed the effectiveness of the ABSN curriculum. Of the 20 learning outcomes on the questionnaire, five related to moral courage values. The 5-point response scale ranged from Not at All, to Somewhat, Moderately, Well, and Extremely Well. t-test calculations revealed significant growth for four of the five values surveyed. Honesty, responsibility, fairness, and compassion were each positively significant at the p < .05 level. For the 27 of the 29 ABSN students who responded to the exit questionnaire, the Well and Extremely Well responses ranged from respectfulness and responsibility at 73%, to compassion and honesty at 78%, and fairness at 82%. Teaching-learning activities to build moral courage values successfully promoted the nursing program objective that the student will demonstrate proficient clinical, technological, and ethical competence in the delivery and management of health care.
Novel Peroxisome–Vacuole Contacts in Yeast
Authors: Wu Huala , van der Klei Ida J.
Published: February 2019

Peroxisomes are important organelles and present in almost all eukaryotic cells. Close associations between peroxisomes and other cell compartments are known for several decades. The first molecular details of physical contacts between peroxisomes and various other organelles are now beginning to emerge. We recently described a novel contact between peroxisomes and vacuoles in the yeast Hansenula polymorpha, which develops during conditions of strong peroxisome proliferation. At such conditions, Pex3-GFP forms focal patches at the peroxisome–vacuole contacts, while overproduction of Pex3 promotes their formation. These results reveal a novel function for Pex3 in the formation of these contacts, where it might act as a tethering protein. We speculate that the peroxisome–vacuole contact is important for membrane lipid transfer at conditions of strong organellar expansion.
RETRACTED ARTICLE: P2P net loan default risk based on Spark and complex network analysis based on wireless network element data environment
Authors: Tong Zeping , Chen Xiaomin
Published: February 2019

P2P net loan is the latest financial lending platform business, which is a new way of borrowing under the background of rapid development of the mobile Internet. Since the beginning of the new century, net loan default has caused P2P companies to break up funds and operate without continuity, which has become an important factor affecting the healthy development of the industry. Therefore, starting from the actual management situation of P2P net loan platform, the default risk of net loan was studied based on Spark technology in wireless network environment. The decision tree data mining algorithm was introduced to construct the early warning model of the net loan default risk, which achieved effective control of risk links. From the fuzzy characteristics that affected the uncertain factors of net loan credit, a hybrid algorithm model of C4.5 decision tree optimization was established. The simulation results show that the hybrid optimization model has good application value.
Surface nuclear magnetic resonance observations of permafrost thaw below floating, bedfast, and transitional ice lakes
Authors: Parsekian Andrew D. , Creighton Andrea L. , Jones Benjamin M. , Arp Christopher D.
Published: February 2019

Lakes in Arctic systems contribute to hydrologic storage, biogeochemical cycling, and permafrost thaw. Here, we have used surface nuclear magnetic resonance (NMR) measurements on lakes of Alaska’s North Slope to investigate the extent of permafrost thaw below lakes with different annual ice conditions. Our purpose is to understand if annual lake ice conditions are related to development of thawed permafrost below lakes. We investigated 10 lakes and two terrestrial permafrost control sites using surface NMR and direct measurement under spring conditions when lake ice is nearly at its thickest. We did not observe unfrozen water below our surveyed bedfast ice lakes, whereas unfrozen water (indicating permafrost thaw) was measured below floating ice lakes. We found that transitional ice lakes, ones that alternate between floating and bedfast ice conditions over multiyear timescales depending on winter ice growth and lake level conditions, have complex vertical unfrozen water content profiles attributed to sporadic periods of thaw. Based on that finding, we speculate that predicting the presence of talik based on remotely sensed lake ice conditions is unreliable. We applied a scheme to subtract the lake water signal from the NMR data and found the resulting inversions to be improved.
High- versus low-intensity interventions for perinatal depression delivered by non-specialist primary maternal care providers in Nigeria: cluster randomised controlled trial (the EXPONATE trial)
Authors: Gureje Oye , Oladeji Bibilola D. , Montgomery Alan A. , Araya Ricardo , Bello Toyin , Chisholm Dan , Groleau Danielle , Kirmayer Laurence J. , Kola Lola , Olley Lydia B. , Tan Wei , Zelkowitz Phyllis
Published: February 2019

Background

Contextually appropriate interventions delivered by primary maternal care providers (PMCPs) might be effective in reducing the treatment gap for perinatal depression.

Aim

To compare high-intensity treatment (HIT) with low-intensity treatment (LIT) for perinatal depression.

Method

Cluster randomised clinical trial, conducted in Ibadan, Nigeria between 18 June 2013 and 11 December 2015 in 29 maternal care clinics allocated by computed-generated random sequence (15 HIT; 14 LIT). Interventions were delivered individually to antenatal women with DSM-IV (1994) major depression by trained PMCPs. LIT consisted of the basic psychosocial treatment specifications in the World Health Organization Mental Health Gap Action Programme – Intervention Guide. HIT comprised LIT plus eight weekly problem-solving therapy sessions with possible additional sessions determined by scores on the Edinburgh Postnatal Depression Scale (EPDS). The primary outcome was remission of depression at 6 months postpartum (EPDS < 6).

Results

There were 686 participants; 452 and 234 in HIT and LIT arms, respectively, with both groups similar at baseline. Follow-up assessments, completed on 85%, showed remission rates of 70% with HIT and 66% with LIT: risk difference 4% (95% CI −4.1%, 12.0%), adjusted odds ratio 1.12 (95% CI 0.73, 1.72). HIT was more effective for severe depression (odds ratio 2.29; 95% CI 1.01, 5.20; P = 0.047) and resulted in a higher rate of exclusive breastfeeding. Infant outcomes, cost-effectiveness and adverse events were similar.

Conclusions

Except among severely depressed perinatal women, we found no strong evidence to recommend high-intensity in preference to low-intensity psychological intervention in routine primary maternal care.

Declaration of interests

None.
Monitoring Muscle Fatigue Progression during Dynamic Exercise
Authors: RANNOU FABRICE , NYBO LARS , ANDERSEN JANNI ENGHAVE , NORDSBORG NIKOLAI B.
Published: February 2019

Purpose

To develop and validate a novel model for assessment of peripheral fatigue progression during dynamic exercise.

Methods

Seven males and four females (24 ± 3 yr) completed one-legged knee-extensor exercise at 40% of peak power output (PPO) for 12 min (40% PPO). Additionally, an exhaustive bout lasting approximately 6 min (84% ± 2% PPO; 59 ± 10 W) was contrasted to two bouts completed at ±5% of the target workload. Trials were completed in randomized order. Percutaneous electrical stimulation of m. vastus lateralis during the passive knee-flexion phase allowed quantification of maximal twitch force every 30 s in parallel with RPE.

Results

Elicited twitch force remained unchanged during the 40% PPO trial. During the three exhaustive bouts, exercise differed in duration (561 ± 154 s, 366 ± 64 s, 245 ± 61 s; P < 0.001) and amplitude of elicited twitch force showed a curvilinear decline across time. Elicited twitch force at exhaustion was approximately 60% reduced and similar between the exhaustive trials (intraclass correlation coefficient, 0.76; 95% confidence interval, 0.48–0.92). The increase in RPE during exercise was strongly correlated to the gradually reduced evoked twitch force (repeated-measures correlation, 0.89; 95% confidence interval, 0.62–0.97).

Conclusions

The developed model permits quantification of muscle fatigue progression during continuous dynamic one-legged knee-extension and a biphasic fatigue pattern is demonstrated during intense exercise. The model is sensitive to small changes in intensity, and it provides a novel approach for studying muscular mechanisms and their temporal relation to fatigue progression in vivo.
Increasing Epstein-Barr virus infection in Chinese children: A single institutional based retrospective study.
Authors: Devkota Kiran , He Maio , Liu Meng Yi , Li Yan , Zhang You Wei
Published: February 2019

The Epstein-Barr virus (EBV) is a common virus in humans and the most common causative agent of Infectious Mononucleosis. EBV primary infection has recently risen in some countries and children below 2 years of age are highly susceptible. The clinical manifestations in children with EB virus infection involve multiple systems, causing severe illness, meaning attention should be paid during diagnosis and treatment.

Objective:  This single institution based retrospective study was carried out with the aim of estimating the overall prevalence of EBV infection and identifying high-risk age group among children. 

Methods: This study include total 253 patients under 15 years of age found to be  positive for EBV DNA by serum PCR who were admitted to the Pediatrics Department of Renmin Hospital,(Shiyan, China) during a 4-year period from 2014 to 2017. Patients were divided into three groups; 0-<4years, 4-<6years and 6-<15years. We then calculated the percentage and prevalence of EBV DNA-positive cases.

Results: The yearly EBV prevalence rate was 4.99 per 1000 admissions in 2014, 6.97 per 1000 admissions in 2015, 10.42 per 1000 admissions in 2016, and 12.16 per 1000 admissions in 2017. Out of 253 EBV-positive cases, those under 4 years had the highest rate of EBV infection (74.7%). The rate drops to 11.06% in the 4-6 years group, and was 14.22% in the 6-15 years group. Those between 6 months and 1 year are those at the highest risk. 

Conclusion: The rate of hospital admission of children due to EBV infection is increasing day by day. Children under 4 years of age are highly susceptible to infection and children of age between 6 months and 1 year are the high-risk group for EBV infection.
A physiological examination of perceived incorporation during trance
Authors: Wahbeh Helané , Cannard Cedric , Okonsky Jennifer , Delorme Arnaud
Published: February 2019

Background:Numerous world cultures believe channeling provides genuine information, and channeling rituals in various forms are regularly conducted in both religious and non-religious contexts. Little is known about the physiological correlates of the subjective experience of channeling.

Methods:We conducted a prospective within-subject design study with 13 healthy adult trance channels. Participants alternated between 5-minute blocks of channeling and no-channeling three times while electroencephalography (EEG), electrocardiography (ECG), galvanic skin response (GSR), and respiration were collected on two separate days. Voice recordings of the same story read in channeling and no-channeling states were also analyzed.  

Results:The pre-laboratory survey data about demographics, perception of the source, purpose and utility of channeled information reflected previous reports. Most participants were aware of their experience (rather than in a full trance) and had varying levels of perceived incorporation (i.e. control of their body). Voice analysis showed an increase in voice arousal and power (dB/Hz) differences in the 125 Hz bins between 0 and 625 Hz, and 3625 and 3875 Hz when reading during the channeling state versus control. Despite subjective perceptions of distinctly different states, no substantive differences were seen in EEG frequency power, ECG measures, GSR and respiration.

Conclusions:Voice parameters were different between channeling and no-channeling states using rigorous controlled methods, but other physiology measure collected were not. Considering the subjective and phenomenological differences observed, future studies should include other measures such as EEG connectivity analyses, fMRI and biomarkers.
The Actualization of the Creation of Centers of Advanced Training
Authors: Пахневская О. , Pahnevskaya O. , Романченко М. , Romanchenko M. , Романченко А. , Romanchenko A.
Published: February 2019

The article outlines the main priorities for the development of the system of advanced training centers, the conditions of creation, activities. The interrelation of standards of WorldSkills.
Vocational Guidance in School: Relevance and New Challenges
Authors: Усова С. , Usova S.
Published: February 2019

The article analyzes the results of studies of the features of the choice of profession and university by modern youth, conducted in 2018. The problems of professional self-determination of schoolchildren are revealed and new tasks of vocational guidance work at school are identifi ed. The material of the authors can be useful for creating an environment for professional self-determination, early career guidance and pre-professional training of schoolchildren in educational organizations.
Latest clinical research
Authors: Greener Mark
Published: February 2019

Mark Greener rounds up the latest papers and reports relevant to primary care nurses
Effects of a topical botanically-enriched salve on cutaneous oxygenation
Authors: Corroon Jamie , Erlandsen Andrew , Taylor Jan , Hanes Doug , Bradley Ryan
Published: February 2019

Objective:

There is a medical need to evaluate new treatments that may improve wound healing. This study aimed to determine if Original Healing Salve (OHS, Puremedy, Inc.) a topical, botanically-enriched salve (BES), changes distal leg tissue oxygenation in people with type 2 diabetes.

Method:

A randomised, controlled, crossover, double-blinded clinical trial comparing changes in cutaneous oxygen delivery (mean TcPO2) on multiple sites of the lower extremity following application of a botanically-enriched topical salve, as compared with application of the salve's base in patients with type 2 diabetes. Subjects were recruited from the general population as a convenience sample.

Results:

A total of 16 participants were recruited. Analysis of the primary outcome demonstrated no statistically significant difference in TcPO2 at 30 minutes postapplication when comparing the BES to the base salve (BS) on the leg (–0.39±8.54mmHg; p=0.86). Analyses of secondary outcomes at 30 minutes postapplication indicated that mean TcPO2 was significantly higher than preapplication levels among subjects receiving both the BES (3.70±6.62mmHg; p=0.04) and BS on the leg (4.08±5.21mmHg; p=0.007). On the foot, mean TcPO2 at 30 minutes postapplication was higher in the BES compared with the BS, this difference was not significant (0.98±8.59mmHg; p=0.66). Mean TcPO2 was higher than preapplication levels among subjects receiving both the BES (1.21±7.70mmHg; p=0.54) and BS on the foot (2.19±7.27mmHg; p=0.25). These differences were non-significant.

Conclusion:

These findings support consideration of topical treatments containing botanical ingredients to increase cutaneous oxygen delivery in the lower extremity in patients with type 2 diabetes.
Pilot study to assess the use of a fluorescence imaging system for assessment of amputation healing
Authors: Hutchison Dylan , Cuff Robert , Liao Tim , Korepta Lindsey , Simmons Justin , Rudy Monica , Holen Jeanine , Hiller Jill Ann , Brock Taylor Ten , Rozwadowski Michael
Published: February 2019

Objective:

The purpose of this study was to use a fluorescence imaging system (FIS) (SPYElite, NOVADAQ, US) during lower extremity amputations and develop parameters to predict amputation healing, for which there are no proven, objective tests. We hypothesised that the FIS may identify areas of poor perfusion at the time of amputation and predict potential healing complications. There are no studies involving the FIS used in this study in lower extremity amputation.

Method:

This prospective cohort study involved patients requiring either below- or above-knee-amputation at one, mid-western medical centre. The FIS was used as per manufacturer's instructions after wound closure and before dressing. Procedure and operative management was unchanged. Through the FIS, perfusion values were plotted along the amputation site to visualise and quantify intraoperative perfusion and to compare with 30-day postoperative amputation healing.

Results:

Surgeons determined that all of the 18 participants had adequate perfusion at surgical wound closure. At 30 days, two subjects had wound dehiscence or infection; these correlated with low perfusion values on the FIS imaging. A further six subjects had marginal or low perfusion values, but did not develop wound failure.

Conclusion:

It is feasible to use the FIS during amputation, however it did not perfectly predict healing course based on vascular perfusion. There were interesting patterns of poor perfusion that correlated with areas of dehiscence or infection but other patients had reduced perfusion that healed well. Due to the small sample size, no discernible perfusion value differences existed between patients who healed and patients with healing complications. A future, larger study may show that the FIS can be predictive of patient healing and aid decisions for intraoperative revision.
Effect of annealing temperature on structural, optical and photocatalytic properties of CuO nanoparticles
Authors: Attou Loubaba , Jaber Boujemaâ , Ez-Zahraouy Hamid
Published: February 2019

In this study, pure crystallographic CuO nanoparticles are successfully synthesized via the sol-gel method through the reduction of copper acetate in water as a solvent. The as-prepared nanoparticles are characterized by X-ray diffraction (XRD), UV-Vis spectrophotometer and transmission electron microscopy (TEM). In order to study the effect of annealing temperature on their morphological and optical behavior, the obtained nanoparticles are annealed at different temperatures, from 200°C to 800°C. XRD studies revealed that by increasing temperature, the full width at half maximum (FWHM) of peaks decreases indicating the enhancement of the grain size of the CuO nanoparticles. Our result also reveals that the optical band gap decreases with the increase of temperature, which can be fully reflected by its variation from 3.83 eV to 2.21 eV when nanoparticle’s size varied from 9.84 nm to 188.33 nm respectively, figured out in TEM analysis. In the studied annealed range temperature, the obtained Eg values remain widely higher than reported bulk values. The photocatalytic deactivation/degradation process significantly enhanced the activity of CuO-NPs under UV–visible light in the presence of MB dye, we compare then the photodegradation spectra of CuO-NPs annealed at 200°C, 400°C, 600°C and 800°C, obtained by UV-visible spectroscopy.
Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer
Authors: Sans Marta , Zhang Jialing , Lin John Q , Feider Clara L , Giese Noah , Breen Michael T , Sebastian Katherine , Liu Jinsong , Sood Anil K , Eberlin Livia S
Published: February 2019

BACKGROUND

Accurate tissue diagnosis during ovarian cancer surgery is critical to maximize cancer excision and define treatment options. Yet, current methods for intraoperative tissue evaluation can be time intensive and subjective. We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Here we evaluated the performance of this technology for ovarian cancer diagnosis across different sample sets, tissue types, and mass spectrometry systems.

METHODS

MasSpec Pen analyses were performed on 192 ovarian, fallopian tube, and peritoneum tissue samples. Samples were evaluated by expert pathologists to confirm diagnosis. Performance using an Orbitrap and a linear ion trap mass spectrometer was tested. Statistical models were generated using machine learning and evaluated using validation and test sets.

RESULTS

High performance for high-grade serous carcinoma (n = 131; clinical sensitivity, 96.7%; specificity, 95.7%) and overall cancer (n = 138; clinical sensitivity, 94.0%; specificity, 94.4%) diagnoses was achieved using Orbitrap data. Variations in the mass spectra from normal tissue, low-grade, and high-grade serous ovarian cancers were observed. Discrimination between cancer and fallopian tube or peritoneum tissues was also achieved with accuracies of 92.6% and 87.9%, respectively, and 100% clinical specificity for both. Using ion trap data, excellent results for high-grade serous cancer vs normal ovarian differentiation (n = 40; clinical sensitivity, 100%; specificity, 100%) were obtained.

CONCLUSIONS

The MasSpec Pen, together with machine learning, provides robust molecular models for ovarian serous cancer prediction and thus has potential for clinical use for rapid and accurate ovarian cancer diagnosis.
"Omen" partikularen erabilera eta gaztelaniazko ordainak: Anjel Lertxundiren kasua / The use of the "omen" particle and its equivalents in Spanish: The case of Anjel Lertxundi
Authors: Cid Abasolo Karlos
Published: February 2019

Omen partikula ebidentziala biziki interesgarria da euskal hizkuntzalari eta itzultzaileentzat. Hizkuntzalarientzat, alboko bi erdaretan horrelako partikularik ez dagoelako, eta itzultzaileentzat, horrek zaildu egiten dielako omen bi hizkuntza horietara egokiro itzultzea. Artikulu honek aztertzen du, alde batetik, nola darabilen Anjel Lertxundik partikula hori Etxeko hautsa eta Zu eleberrietan, eta, bestetik, eleberrion gaztelaniazko itzulpenetan nola izan den itzulia: egiaztatu dugunez, itzultze-estrategia bat baino gehiago darabilte Jorge Giménez Bech eta Gerardo Markuleta itzultzaileek. Estrategia bakoitzaren hautuaren zioa antzematea da lan honen hirugarren helburua.
La red vascológica de Schuchardt / Schuchardt’s bascological network
Authors: Hurch Bernhard
Published: February 2019

Among the founding factors for modernism in philology/linguistics, there were two important medial innovations as a consequence of industrialization: new printing technologies and the installation of a general mail system. This contribution explores their catalyzing effects on the basis of Schuchardt’s bascology, showing that the (pre-)academic network of epistolary exchange, of reviewing and other types of contact, which had been created by those innovative scholars, is at least as important for the development of the humanities as the publications in sensu stricto. Moreover, this paper illustrates modern techniques applied in the digital and open source «Hugo Schuchardt Archiv», which virtually reconstruct the network which had existed in the 19th century. The archive publishes, among other things, at the moment nearly 8,000 letters with originals, transcription and comments (from which around 1,700 with bascological interest).
Antzinateko "Iturissa"-tik gaurko "ithurri"-ra, ezker bidetik / From ancient "Iturissa" to modern "ithurri", through the left-hand door
Authors: Manterola Julen
Published: February 2019

Artikulu honetan, iturri eta ezker euskal hitzentzat proposamen etimologiko berri bana egiten dut. Uhlenbeckekin bat, partizipio zahartzat jotzen dut iturri, eta erroa hur dela proposatu. Ezker hitzari dagokionez, berriz, hezi aditzaren erro bera dagoela proposatzen dut, eta etimologikoki 'hezigaitz' litzatekeela, eskuari gagozkiolarik.
Influence of Body Mass Index on Outcomes of Patients Undergoing Surgery for Acute Aortic Dissection: A Propensity-Matched Analysis
Authors: Lio Antonio , Bovio Emanuele , Nicolò Francesca , Saitto Guglielmo , Scafuri Antonio , Bassano Carlo , Chiariello Luigi , Ruvolo Giovanni
Published: February 2019

To determine whether body mass index ≥30 kg/m2 affects morbidity and mortality rates in patients undergoing surgery for type A acute aortic dissection, we conducted a retrospective study of 201 patients with type A dissection. Patients were divided into 2 groups according to body mass index (BMI): nonobese (BMI, <30 kg/m2; 158 patients) and obese (BMI, ≥30 kg/m2; 43 patients). Propensity score matching was used to reduce selection bias.

The overall mortality rate was 19% (38/201 patients). The perioperative mortality rate was higher in the obese group, both in the overall cohort (33% vs 15%; P=0.01) and in the propensity-matched cohort (32% vs 12%; P=0.039). In the propensity-matched cohort, patients with obesity had higher rates of low cardiac output syndrome (26% vs 6%; P=0.045) and pulmonary complications (32% vs 9%; P=0.033) than those without obesity. The overall 5-year survival rates were 52.5% ± 7.8% in the obese group and 70.3% ± 4.4% in the nonobese group (P=0.036). In the propensity-matched cohort, the 5-year survival rates were 54.3% ± 8.9% in the obese group and 81.6% ± 6.8% in the nonobese group (P=0.018).

Patients with obesity (BMI, ≥30 kg/m2) who underwent surgery for type A acute aortic dissection had higher operative mortality rates and an increased risk of low cardiac output syndrome, pulmonary complications, and other postoperative morbidities than did patients without obesity. Additional extensive studies are needed to confirm our findings.
Spontaneous Resolution of Residual Shunting in 2 Compromised Patients after Amplatzer Occlusion of Postinfarction Ventricular Septal Defects
Authors: Yanagiuchi Takashi , Tada Norio , Suchi Taro , Mizutani Yukiko , Matsumoto Takashi , Sakurai Mie , Ootomo Tatsushi
Published: February 2019

Ventricular septal defect (VSD) is a rare, potentially fatal complication of acute myocardial infarction. When surgical closure is contraindicated, transcatheter closure may be an alternative. Residual shunting after transcatheter closure of postinfarction VSDs has been reported; however, we found few cases of this in patients who also had severe heart failure or hemolysis.

We report 2 closures of postinfarction VSDs with use of the Amplatzer Septal Occluder. Both elderly patients—one with severe heart failure, one with persistent hemolysis, and neither a surgical candidate—had high-velocity residual shunting through the occluders. We intensively managed the patients' conditions and used angiography and transthoracic echocardiography to record the gradual disappearance of each shunt over 4 months—the first such serial monitoring of which we are aware. We think that even substantial shunting in the presence of severe heart failure or hemolysis can eventually resolve spontaneously, assuming effective management of the concomitant medical conditions.
Carcinoid Heart Disease: Review of Current Knowledge
Authors: Ram Pradhum , Penalver Jorge L. , Lo Kevin Bryan U. , Rangaswami Janani , Pressman Gregg S.
Published: February 2019

Carcinoid heart disease is the collective term for all cardiac manifestations in patients who have carcinoid syndrome. Carcinoid heart disease has a multifactorial pathophysiology, and the right side of the heart is usually involved. Symptoms and signs vary depending upon the affected cardiac components; most typical is right-sided heart failure secondary to diseased tricuspid and pulmonary valves. Despite no single ideal diagnostic test, strong suspicion, coupled with serologic and imaging results, usually enables diagnosis. Advances in imaging, such as speckle-tracking echocardiography and cardiac magnetic resonance, have improved the diagnostic yield. Treatment is challenging, warrants a multidisciplinary approach, and can be medical or surgical depending on the cardiac manifestations. Investigators are exploring the therapeutic use of monoclonal antibodies and new somatostatin analogues. In this review, we cover current knowledge about the pathophysiology, diagnosis, and treatment of carcinoid heart disease.
Experimental study of the coccidial infection on growth performance of juvenile of Clarias gariepinus Burchell, 1822 (Poisson, Siluriformes)
Authors: IBIKOUNLE Moudachirou , HOUENOU Mireille Sèdogbo , GBANKOTO Adam , TOKO Ibrahim IMOROU , TOSSAVI Darius Nounagnon
Published: February 2019

The study focused on the characterization and quantification of the effects of coccidiosis on intensive rearing of Clarias gariepinus production. The first phase of works, performed on 117 specimens of C. gariepinus consisted of the
collection of oocysts of Coccidia which served as inoculum. The experimental phase was conducted on 81 juvenile of C. gariepinus divided into three groups (T, I and II) including 27 fish specimens per group. Group T served as control group; groups I
and II were infected orally with respectively 600 and 500 oocysts from the inoculum. The results show a high parasite load in adult specimens of C. gariepinus harvested in the wild. The collection of oocysts has allowed to identify four (04) species
of Cyclospora and two (02) species of Eimeria. After infection of juvenile of C. gariepinus, the presence of lesions including intestinal congestion and stomach distension indicates the pathogenic effects of the infestation. The performance analysis
showed that the weight of juvenile from control group is significantly higher (p ltss than 0.001) than those from infected groups I and II at D7, D14 and D21. Groups I and II also show weight loss at D7 and D21, characterizing negative specific
growth rate (SGR), particular for group II. Infestation rates of groups I and II are respectively 33.33% and 29.62%. These results show a real impact of coccidiosis on juvenile of C. gariepinus bred in captivity, including the effectiveness of heavy
infestation and deteriorating of growth performance of fish.
Gamifikacja edukacji – badanie motywacji studentów
Authors: Skok Katarzyna , Harasimczuk Wojciech
Published: February 2019

Celem obecnej pracy było określenie emocjonalnego i motywacyjnego nastawienia studentów do wybranych elementów gamifikacji. Badane były oceny poziomu motywowania oraz podobania się dla wykorzystania w procesie edukacji następujących narzędzi: komunikatory, punkty, odznaki, rankingi, misje, wyzwania, pasek postępu, poziomy, rywalizacja grupowa, rywalizacja indywidualna, współpraca, system wymiany, wirtualne przedmioty. Dodatkowo – w ramach pilotażu – testowana była opinia na temat drobnych gratyfikacji pieniężnych. Wyniki wskazały na znaczące zainteresowanie gamifikacją. W szczególności pozytywnie oceniane były elementy mogące wpłynąć na uzyskanie lepszej oceny końcowej i poprawiające organizację procesu uczenia i samonauczania. Niżej były oceniane mechanizmy potencjalnie zagrażające samoocenie.
Multi-dimensional periodic problems for higher-order linear hyperbolic equations
Authors: Kiguradze Tariel , Al Jaber Noha
Published: February 2019

For higher-order linear hyperbolic equations the problem on periodic solutions is investigated. The concepts of associated problems, and α-well-posedness are introduced.
Necessary and sufficient conditions of well-posedness in the two-dimensional case, as well as unimprovable sufficient conditions of well-posedness and α-well-posedness in the multi-dimensional case are established.
Construction of Green’s functional for a third order ordinary differential equation with general nonlocal conditions and variable principal coefficient
Authors: Özen Kemal
Published: February 2019

In this work, the solvability of a generally nonlocal problem is investigated for a third order linear ordinary differential equation with variable principal coefficient. A novel adjoint problem and Green’s functional are constructed for a completely nonhomogeneous problem. Several illustrative applications for the theoretical results are provided.
L2L^{2} boundedness for commutators of fractional differential type Marcinkiewicz integral with rough variable kernel and BMO Sobolev spaces
Authors: Chen Yanping , Ding Yong , Zhu Kai
Published: February 2019

In this paper, for

0
<
γ
<
1

{0<\gamma<1}

and

b
∈

I
γ

⁢

(
BMO
)

{b\in I_{\gamma}(\mathrm{BMO})}

, the authors give the

L
2

⁢

(

ℝ
n

)

{L^{2}({\mathbb{R}}^{n})}

boundedness of

μ

γ
;
b

{\mu_{\gamma;b}}

, the commutator of a fractional
differential type Marcinkiewicz integral with rough variable kernel,
which is an extension of some known results.
The probabilities of winning a racquetball doubles match motivate a fairer side-out scoring scheme for singles and team events
Authors: Peters James E. , Peters Christopher J.
Published: February 2019

We explore the probabilities of winning a best-of-three doubles racquetball match given the probabilities that each of the participants wins a point while serving. We restrict our attention to the cases where these probabilities are between 0.4 and 0.6 for all participants; in other words, the cases where all of the players are moderately evenly matched. In doing so, we find it sensible to suggest changes to the side-out scoring schemes in singles and in team events. These changes would cause each game played to be more fair while preserving the fairness of a match, for which there seems to be adequate impetus.
Population trends of Peregrine Falcon in Northern Spain – Results of a long-term monitoring project
Authors: Zuberogoitia Iñigo , Morant Jon , Castillo Iñaki , Martínez Jose Enrique , Burgos Gorka , Zuberogoitia Julen , Azkona Ainara , Guijarro Julio Ruíz , González-Oreja Jose Antonio
Published: February 2019

We monitored Peregrine Falcon(Falco peregrinus)population in Bizkaia, Northern Spain, during two decades (1998–2017). Our population increased from 34 to 47 territorial pairs, as did other European populations until the first years of the 21stcentury, and then declined until 34 territorial pairs in 2017. The combination of catastrophic events (Prestige oil spill), increasing rain in winter and spring, and direct and indirect mortality factors significantly affected incubation onset, productivity and population stability, which in turn could impact on the floater population. Rain in February significantly affected incubation onset, which showed a slight positive trend during the last decade. Juvenile females laid 12 days later than adults, and each adult female started incubation in the same dates every year. However, the proportion of juvenile females did not significantly increase as might have been expected. Moreover, productivity was inversely related to incubation onset dates. Rain in April and May also affected productivity, and combined with short term extreme weather events determined a decreasing productivity during the last decade. Moreover, apart from human persecution (which caused 40.30% of the known deaths of Peregrines), we found 18 cases of breeders affected by infectious diseases, also related to weather. The combined effects of these factors, and the low availability of adequate nesting sites, negatively affected (i) territorial populations, (ii) productivity, and (iii) floater population, which in turn also determined territorial population and productivity.
Onset of natal dispersal in Peregrine Falcon from Mediterranean islands (Italy)
Authors: Bond Salvatore , Guzzo Enrico , Mascara Rosario , Sarà Maurizio
Published: February 2019

Basic information on natal dispersal of Peregrine Falcons is virtually lacking in Europe, despite increased attention on this species, and the sensitivity of this stage in the Peregrines’ life history. In this study, we collected satellite telemetry data during the onset of natal dispersal of 19 Peregrine Falcons tagged in Sicily and the Aeolian archipelago (Italy). We divided the onset of dispersal into the following 3 periods: post-fledging dependence period (PFDP), wandering, and wintering. PFDP lasted on average 47±16 days, during which young peregrines moved very little (0.167 km), and explored small areas (0.226 km2) far from the nest cliff, and showed no sex differences. The wandering phase was highly individualistic, with median net displacements of 23.97 km. Both PFDP and wandering bearings were oriented towards NNE-ESE. Only five individuals went sporadically outside the island borders. During their first winter, Peregrines had a mean home range of 135.65±82.31 km2 spatially scattered across Sicily and mainly composed of open habitats, like cereal steppes, arboreal crops and agri-mosaics. Individuals had a dissimilar assortment in habitat composition, however the urban habitat was the most selected and the woodland the least. At night, during both wandering and wintering phases Peregrines used rocks, cliffs and electricity pylons in frequencies not statistically different between sex, phase and type of roost. Only two individuals had significant use of pylons and one of rocks. The multifaceted framework of Peregrine Falcon’s natal dispersal was described here for the first time in a Mediterranean population.
Dynamic Correspondence of Resistance Training to Sport: A Brief Review
Authors: Suarez Dylan G. , Wagle John P. , Cunanan Aaron J. , Sausaman Robert W. , Stone Michael H.
Published: February 2019

THE PROPER APPLICATION OF THE PRINCIPLE OF SPECIFICITY IS ESSENTIAL TO ANY STRENGTH AND CONDITIONING PROGRAM. HOWEVER, THE TRANSFER OF RESISTANCE TRAINING TO SPORT IS HIGHLY COMPLEX, DIFFICULT TO PREDICT, AND CHALLENGING TO ASSESS. THIS BRIEF REVIEW EXAMINES THE PRINCIPLE OF DYNAMIC CORRESPONDENCE AS AN AID TOWARD BETTER UNDERSTANDING AND PREDICTING AN EXERCISE OR TRAINING METHOD'S POTENTIAL TRANSFER TO SPORT. PRACTICAL TRAINING RECOMMENDATIONS ARE GIVEN BASED ON THE RESEARCH REVIEWED.
Вплив соціальних інституцій на розвиток обдарованості дитини
Authors: Lemko Galyna , Kovbas Bogdan
Published: February 2019

У статті виокремлено види обдарованості й обґрунтовано вплив на розвиток обдарованості дитини таких соціальних інституцій, як сім’я, дошкільні заклади, школа і позашкільні освітньо-виховні заклади.
Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele
Authors: Korecki Andrea J , Hickmott Jack W , Lam Siu Ling , Dreolini Lisa , Mathelier Anthony , Baker Oliver , Kuehne Claudia , Bonaguro Russell J , Smith Jillian , Tan Chin-Vern , Zhou Michelle , Goldowitz Daniel , Deussing Jan M , Stewart A Francis , Wasserman Wyeth W , Holt Robert A , Simpson Elizabeth M
Published: February 2019

To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cre-drivers) that restrict expression to specific cell types. To address these problems, a high-throughput method for large-scale production that produces high-quality results is necessary. Further, endogenous promoters need to be chosen that drive cell type specific expression, or we need to further focus the expression by manipulating the promoter. Here we test the suitability of using knock-ins at the docking site 5′ of Hprt for rapid development of numerous cre-driver strains focused on expression in adulthood, using an improved cre tamoxifen inducible allele (icre/ERT2), and testing a novel inducible-first, constitutive-ready allele (icre/f3/ERT2/f3). In addition, we test two types of promoters either to capture an endogenous expression pattern (MaxiPromoters), or to restrict expression further using minimal promoter element(s) designed for expression in restricted cell types (MiniPromoters). We provide new cre-driver mouse strains with applicability for brain and eye research. In addition, we demonstrate the feasibility and applicability of using the locus 5′ of Hprt for the rapid generation of substantial numbers of cre-driver strains. We also provide a new inducible-first constitutive-ready allele to further speed cre-driver generation. Finally, all these strains are available to the research community through The Jackson Laboratory.
Expectativas dos alunos do primeiro semestre dos cursos de engenharia
Authors: Hoernig Junior Breno Arno , Fossatti Paulo
Published: February 2019

O tema deste artigo está relacionado às expectativas apresentadas pelos alunos que iniciam sua jornada acadêmica numa Instituição de Ensino Superior Comunitária (IESC) no sul do Brasil. Este estudo tem por objetivo identificar as expectativas dos alunos ingressantes nos diferentes cursos de Engenharia oferecidos por Instituição de Ensino Superior Comunitária (IESC). A metodologia adotada é do tipo qualitativa descritiva, pois trata-se de um estudo de caso, onde participam do levantamento alunos das Engenharias. Foi feito um levantamento estatístico com os dados demográficos a fim de caracterizar o grupo de interesse da pesquisa, usando o programa aplicado a Estatística -  SPSS. A seguir fez-se uma categorização das respostas associadas ao questionário aberto sobre suas expectativas, que foi aplicado aos alunos matriculados em uma disciplina de primeiro semestre. Os resultados apontam que os alunos têm expectativas voltadas à atividade profissional futura e, principalmente, a qualidade em sua formação acadêmica, que se mostrou como sendo a expectativa de maior ênfase. Sepùlveda (2013, p.1) chama atenção de que tal situação ocorre também no contexto da educação superior no Chile, onde ele menciona têm-se ” una generación ambiciosa que tiende a postergar el ingreso al mundo laboral y que reconoce en las credenciales educativas un requisito fundamental para su inserción en el mundo adulto”.  Conclui-se que a expectativas dos alunos, apesar de incertas e muitas vezes inconstantes, devem ser objeto de interesse da instituição, a fim de que, ao atender estas expectativas estimule a permanência do aluno até a sua conclusão na graduação da Engenharia.