bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamics of motor and emotional infringements, qualities of life during the regenerative period of a stroke
Authors: Chistyakova V. A. , Katayeva N. G.
Published: June 2020

In the article presented results on research of dynamics of impellent and emotional infringements, qualities of life of poststroke patients in the regenerative period against the spent physical rehabilitation including methods of mirror therapy and proprioceptive correction. By surviving of 39 patients was shown the efficiency of rehabilitation actions on key parameters of impellent activity and self-service degree. During the regenerative period was revealed increase of frequency, but reduction of expressiveness of disturbing-depressive infringements, life improvement of quality poststroke patients.
Pulmonary hemodynamics and diastolic function of right ventricle at isometric exercises in children with chronic bronchopulmonary pathology
Authors: Agapitov L. I. , Belozerov Yu. M. , Mizernitsky Yu. L. , Tsyplenkova S. E.
Published: June 2020

We studied pulmonary hemodynamics and right ventricular diastolic function in 300 healthy children and 392 children with chronic bronchopulmonary pathology in an isometric exercise. Using echocardiography were determined systolic, diastolic, mean, pulmonary artery pressure, total pulmonary resistance, diastolic function of the right ventricle. Defined normal values of reactivity of pulmonary hemodynamics and diastolic function of the right ventricle in an isometric load. In patients with chronic bronchopulmonary pathology set higher increase of systolic, diastolic, mean, pulmonary artery pressure, decrease diastolic reserve the right ventricle compared to the control. The worst violations of pulmonary hemodynamics and diastolic function of the right ventricle during isometric load observed in patients with chronic Infectious-inflammatory and interstitial lung disease.
Approaches to the development of individualized schemes for treatment of otitis media with effusion in patients with low efficiency of traditional conservative therapy
Authors: Ochirov D. D. , Scherbik N. V. , Kologrivova Ye. N. , Starokha A. V.
Published: June 2020

Management of otitis media with effusion is a challenging problem in view of its high prevalence and frequent complications in the form of stable hearing loss. High frequency of secondary immunodeficiencies in ENT diseases dictates the necessity of immunocorrection in combined treatment. Dinamic pure tone audiometry, tympanometry and subjective response demonstrated higher treatment efficiency in the «Gepon» groups.
Effect of polyphenolic complexes wood and cellular culture Maackia amurensis on the MR тomography performance of a liver
Authors: Chuchalin V. S. , Ratkin A. V. , Ratkin Ye. V. , Fedoreyev S. A. , Bulgakov V. P.
Published: June 2020

Comparative evaluation of hepatoprotective properties of polyphenolic fraction from wood (Maksar) and a polyphenolic complex of cell culture of Maakia amurensis.

Therapeutic efficacy of the objects was assessed by their effect on the MR tomographic performance of the liver of rats with experimental СCl4-hepatitis. Hepatoprotective activity of polyphenol complex cell culture Maakia amurensis is not inferior to the original effect of the drug Maksar.
Evaluation of approaches to management of a pharmaceutical organization
Authors: Drugova Z. K. , Biteryakova A. M. , Tilman M. P.
Published: June 2020

Nowadays the great attention is paid to problems of construction of efficient system management. Toward this end, we have considered the following aspects of the activity, which allow us to characterize the management system in general: evaluation of the existing management system, evaluation of the degree of formalization of the management system, and evaluation of the customerorientation index. Management approaches were evaluated comparatively using pharmacy network as an example. It has been shown that implementation of new technological management approaches enhances the organization potential.
Liver ultrastructure under the action of small fluorine doses
Authors: Gaidash A. A. , Babenko O. A. , Bashirov R. S.
Published: June 2020

In experiment on laboratory rats Wistars by a method of appearing through electronic microscopy of a liver it is established, that at action of small doses of fluorine (0,5 mg/kg of a fluorine-ions within 1 month) hepatocitys are exposed destructions by damp lyses, and endoteliocitys — apoptosis. A special kind destructions is migration mytochondris in kernels hepatocitys with the subsequent formation megaautohpagosomes and them lyses. In basalition to a membrane develops fibrosis and appear pathological message between space Disse and a gleam of sinusoidal capillaries. The conclusion that small doses of fluorine close to used at osteoporosis correction, cause destructive changes in a liver that does necessary to carry out the actions directed on inactivation of fluorine becomes.
Department of Pathophysiology of Siberian State Medical University: 120th anniversary of scientific and pedagogical activity
Authors: Urazova O. I. , Nekrylov S. A.
Published: June 2020

The article is dedicated to the 120th anniversary of the foundation day of the Department of General Pathology (Pathophysiology) of the Imperial Tomsk University - Tomsk Medical Institute - Siberian State Medical University and scientists whose scientific and pedagogical activity as well as career paths are connected with the Department and Tomsk Cathedral Scientific School of Pathophysiologists, one of the oldest schools in Russia and the first one in the Asian part of Russia. Main directions of school's scientific and research work of the past years are described in the article as well as its present day achievements in science. Special attention is paid to the activity of the head directors and the best representatives of the Tomsk Pathophysiological School such as P.M. Albitsky, A.V. Reprev, D.I. Timofeevsky, P.P. Avrorov, A.D. Timofeevsky, L.F. Larionov, D.I. Goldberg, E.D. Goldberg, V.S. Lavrova, who made a significant contribution to the development of the Russian medical science and medical education. The data on the leading scientific school of the Russian Federation under the leadership of the RAMS Academician V.V. Novitsky is presented in the article.
Adenosine-dependent regulation of paracrine factors expression in human venous blood monocytes
Authors: Ryzhov S. V. , Yuryeva K. S. , Goremykin K. V. , Korotkaya Ye. V. , Saltykova I. V. , Yakovleva Yu. A. , Kulikov Ye. S. , Fyodorova O. S. , Kremer Ye. E. , Fattakhov N. S. , Sazonov A. E.
Published: June 2020

The flow cytometry analysis of human peripheral blood monocytes separated by a two step density gradient centrifugation is reported. The expression of mRNA level of adenosine receptor (AdoR) subtypes (A1, A2A, A2B and A3) and interleukin 6 (IL-6), interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) in monocytes were determined using real-time PCR. We found considerable variation across individuals in mRNA expression levels of paracrine factors after the stimulation of adenosine receptors. Our findings suggests the role of adenosinergic system accounted for interindividual differences in monocyte activation.
Blood supply of adrenals in renal artery stenosis
Authors: Mitrofanova M. S.
Published: June 2020

«Renal» blood supply sources of adrenals in the norm are studied in the work as well as blood supply peculiarities of unilateral adrenal and kidney in renal artery stenosis are revealed. It is concluded that including the study of adrenal arteries into angiographic algorithm in case of renal artery stenosis is of necessity.
Broncho-phonography as a method for predicting the outcome of respiratory distress syndrome in preterm infants
Authors: Pavlinova Ye. B. , Oksenchuk T. V. , Krivtsova L. A.
Published: June 2020

Respiratory distress syndrome infants — the most common pathology in preterm infants, as well as the reason for the formation of such chronic lung diseases as bronchopulmonary dysplasia. Possibility of using new research techniques, such as bronchophonography to assess functional changes in the respiratory tract and predict the outcome of BPD in preterm with RDS is quite promising. The article presents the results of a prospective cohort study of comparative parameters broncho-phonography in preterm infants with respiratory distress syndrome. Using the method of logistic regression, a mathematical model to predict the risk of bronchopulmonary dysplasia in this group of children. Determined that the most common form bronchopulmonary dysplasia premature, at which the probability of occurrence greater than or equal to 50%.
Surgical treatment of funnel chest in children using titanium nickelide materials
Authors: Slizovsky G. V.
Published: June 2020

Reflects stages of funnel chest treatment in the Tomsk Region from 1977 to 2009 has been presented. The work provides analysis of surgical treatment of 78 patients, including 42 patients were operated by means of thoracoplasty with the following fixation of costosternal complex using previously chilled titanium nickelide plates, which have thermodynamic properties.
Forecasting of an arterial hypertensia at women depending on age and character of labor activity
Authors: Artamonova G. V. , Maksimov S. A. , Indukayeva Ye. V. , Shapovalova E. B. , Makarov S. A. , Ivanova O. A. , Ogarkov M. Yu. , Skripchenko A. Ye.
Published: June 2020

The analysis of possibilities of forecasting of an arterial hypertensia depending on age and character of professional work of 607 women of mass trades is carried out. It is shown that groups of the raised and high risks of development of an arterial hypertensia make women is more senior 40 years, working in the trades characterised by physical work, and also brainwork.
The condition of cerebral hemodynamic at patients with cervical injury of spine
Authors: Vstavskaya T. G. , Larkin V. I. , Reznik L. B. , Nazarova N. I.
Published: June 2020

The condition of cerebral hemodynamic at the patients who transferred a cervical trauma of a backbone during the early and intermediate periods was studied. Examined 48 patients at the age of 18—50 years with cervical injury of spine during the early and intermediate periods. Patients were grouped according anatomical particularizes of cervical cord injury and influenced at spinal cord. Besides neurologic inspection, methods of ultrasonic Doppler sonography extracranial and transcranial Doppler sonography of intracranial brain vessels. The most essential changes of a blood-groove were registered in vertebrobasilar pool in a group with a complicated inferior cervical backbone trauma (deficiency of a blood-groove on 30—32% from control group р < 0,05). At patients with not complicated inferior cervical trauma authentically changed only intracranial blood-groove on vertebralis arteries (decrease on 19—26% on the average; р < 0,05). Characteristic changes for patients with a cranivertebral trauma of hemodynamic have not been revealed. The cerebral hemodynamic during the early and intermediate periods was changed at the patients on severity lower level of a cervical trauma of a backbone.
On the problem of terminology and classification in birth developmental defects and morphogenetic variants
Authors: Antonov O. V. , Filippov G. P. , Bogachyova Ye. V.
Published: June 2020

Based on his own results and the latest literature evidence the author raises a point concerning the birth defects nosological forms and birth morphogenetic readings registration. Living hitherto in the literature conception differences regarding terms «birth developmental defects» and «birth morphogenetic variants» stipulate for the significance of varied approach in definition birth defect as developmental defects or as developmental anomaly taking into consideration the insight of distinction in these states. The author proposes the addition to the subsist in native literature term «birth developmental defects» Registration of birth defects according to the latest International Classification of Diseases with the register organization of all birth defects apart from the register of birth anomalies is specificated in the paper.
Clinical and hormonal status of boys-teenagers with type 1 diabetes
Authors: Solodilova Ye. A. , Kondratiyeva Ye. I. , Kravetz Ye. B. , Gorbatenko Ye. V.
Published: June 2020

The research objective consisted in current studying puberty the period at boys with type 1 diabetes. Boys have entered into research 11—18 years. The estimation of physical, sexual development, a lipid and hormonal spectrum was spent; ultrasonic research inguinal and scrotal areas were estimated. Prolongation of early stages of puberty was marked, in 9,4 % of cases the delay of sexual development is revealed.
Comparative estimation of mucous membrane of maxillary sinus ultrastructural changes at aspergillosis different forms
Authors: Baydik O. D. , Sysolyatin P. G. , Loginova O. V.
Published: June 2020

Research objective was establishment of ultrastructural changes of mucous membrane maxillary sinus (MM MS) at noninvasive and chronic invasive aspergillosis. By methods of light, electronic microscopy and morphometry it is established, that the basic signs of endocellular reorganisation of epithelial cells at noninvasive form are decrease in squirrels-synthetic and plastic functions. On separate sites of epithelium there are the cages characterised small changes by cytoplasmatic organells. As a whole, the revealed changes testify to loss of epithelium protective and barrier properties, and as consequence, its defective participation in mucocilliar clearance. At invasive form of aspergillosis sinusitis, despite revealed single-layered metaplasia, in epithelial cells was observed fiber-synthetic and plastic processes that can specify on high reparative possibilities of epithelium.
Pathogenetic basis of capillary mycroaneurisms development of the retina
Authors: Shilova O. G. , Klykov I. I. , Philippova S. V. , Zapuskalov I. V.
Published: June 2020

Large-scale deformations of a homogeneous sphere and a cylinder obeying Hooke’s law were considered. It was shown that under certain conditions the deformations acquire catastrophic character. The magnitude of pressure and strength properties of vessels at which the deformations are bootsing at high rates were estimated.
Molecular mechanisms of regulatory action of heat shock protein 27 kDa in the apoptosis of tumor cells
Authors: Kaigorodova Ye. V.
Published: June 2020

Score mRNA expression and the level of Hsp27 (Heat shock protein 27) and phospho-Hsp27 in tumor cell line Jurkat and THP-1, as well as in mononuclear leukocytes obtained from healthy donors was investigated. In tumor cells, Jurkat and THP-1 Hsp27 plays the role of inhibitor of apoptosis, by influencing the ratio of antiapoptotic (Bcl-2) and proapoptotic (Bax and Bad) proteins.
Elaboration of the bischofite eye drops using the biopharmaceutical criteria
Authors: Sysuev B. B. , Sysuev Ye. B. , Mitrofanova I. Yu.
Published: June 2020

Our research is of theoretical and practical importance and aims at the development of ophthalmological dosage form comprising mineral component (bischofite). It is mineral complex consisting of 96% magnesium chloride with macro- and microelements. Having carried out complex physicochemical and biopharmaceutical researches in vitro, we developed composition and technology of 10% bischofite solution in the form of eye drops. After is one of the perspective tools in technological researches. After using of the analytic hierarchy process by T. Saaty the optimal eye drops composition was selected according to all chosen criteria for this pharmaceutical form.
Innovative approaches in the technology of preparations on a basis of cholagogae species
Authors: Chuchalin V. S. , Abramova Ya. I. , Sheykin V. V. , Teplyakova Ye. M.
Published: June 2020

The technology of a tablet form of herbal medicine on the base of a standardized extractive complex is developed. It is possessed of well-defined cholagogae, antispasmodic and anti-inflammatory action. This development is an innovative product, which represent an alternative of officinal plant species (traditional and imperfect form) and constitutes an effective technology of bioactive substances extraction from the plant species. It is a rational mixture and technology of tablet form as well as a control method of raw materials, an intermediate product and a standardization of a final product too.
Research of phenolic compound of a horsetail wood (Equisetum sylvaticum L.)
Authors: Bondarchuk R. A. , Kolomiets N. E.
Published: June 2020

The results of research of phenolic compounds in an elevated part of a horsetail wood, growing in Tomsk and Kirov Regions are presented. The quantitative estimation of flavonoids and phenolic acidsspent of spectrophotometric method. Qualitative structure of phenolic compoundsstudied by chromatography. It is established that the Siberian samples have more various structure flavonoids and phenolic acids. Nine constant substances for samples of a horsetail wood in independence of a growth place are defined.
New plant agents with cerebroprotective effect
Authors: Burkova V. N. , Vengerovsky A. I. , Suslov N. I. , Kaigorodtsev A. V. , Nasanova O. N. , Yatsenkov A. I. , Grishina Ye. I. , Melik-Gaikazyan Ye. V. , Fisanova L. L.
Published: June 2020

The meadowsweet (Filipendula vulgaris) extract in a greater degree, than valerian extract improves in albino rat's brain the kinetic characteristics of mitochondrion respiratory activity, increases the association of substrate oxidation with ADP phosphorylation in experimental posthypoxic encephalopathy. The nettle (Urtica dioica) extract increases in albino rat's brain the rate of cycle Krebs substrate utilization and oxidative phosphorylation coupling in experimental inhibition of fatty acids p-oxidation caused with 4-pentenoic acid. The meadowsweet and nettle extracts posses the expressed antioxidant effect.
Antioxydant and prooxydant effects of arbutin and hydrohinon in experiment in vitro
Authors: Voloboy N. L. , Zverev Ya. F. , Bryukhanov V. M. , Talalayeva O. S. , Zamyatina S. V. , Zyablova O. N. , Smirnov I. V.
Published: June 2020

The object of research is to compare antioxidant and prooxydant activity of arbutin and hydrochinon in vitro. Antioxidant and prooxydant activity of arbutin and hydrochinon is estimed of their ability to suppress/ induct oxydation ТВИН-80. Arbutin and hydrochinon have antioxydant and prooxydant properties. The conclusions are, that hydrochinon is more antioxydant, arbutin is more prooxydant.
The suprahiazmatic nucleus of the forward hypothalamus destruction and circadian rhythms of moving activity, body temperature and renal excretion of Nа+, Cа2+, K+, Li+ in rats in summer solstice
Authors: Zamoshchina T. A. , Meleshko M. V. , Logvinov S. V. , Matveуenko A. V. , Novitskaya L. N. , Ivanova Ye. V.
Published: June 2020

In summer solstice it was established that right or left suprachiazmatic nucleus lesion breaks circadian rhythms of rat's moving activity in «open field» and lithium urine excretion. Damage of the left nuclei in a greater degree affects formation circadian rhythm of sodium renal excretion, destruction of the right nuclei - the calcium rhythm organization. The rhythms of body temperature and potassium urine excretion find weak sensitivity to reenergizing right or left suprachiazmatic nucleus. At destruction right or left suprachiazmatic nucleus are formed rhythm's desynchronization, character and expressiveness are defined by an illumination mode.
Monosaccharide composition of the leaves Tussilago farfarae the polysaccharide complex
Authors: Korzh A. P. , Guriev A. M. , Belousov M. V. , Yusubov M. S. , Belyanin M. L.
Published: June 2020

The composition of water-soluble polysaccharides of the leaves Tussilago farfara L., possessing anti-allergic properties. It is shown that the polysaccharide complex consists of galacturonan I (33%) and neutral polysaccharides (67%).
Study of amino-acid structure Lemna minor L
Authors: Nikiforov L. A. , Belousov M. V. , Fursa N. S.
Published: June 2020

For the first time qualitative and quantitative amino-acid structure Lemna minor L. is studied with use of a highly effective liquid chromatography. Presence 18 proteinogennic amino acids, including 8 irreplaceable is established. The sum of replaceable amino acids of a duckweed small is presented monoaminocarboxylic,monoaminodicarboxylic, diaminomonocarboxylic and heterocyclic acids. Irreplaceable amino acids are presented monoaminomonocarboxylic and diaminomonocarboxylic by acids.
Benzobarbital and fluorbenzobarbital - hepatic monooxygenase system phenobarbital-like inducers
Authors: Novozheyeva T. P. , Smagina M. I. , Cherevko N. A. , Fateyeva S. N.
Published: June 2020

Benzobarbital and fluorbenzobarbital as monooxygenase system inductors increase the hepatic cytochrome P-450 level and the content of its isoenzymes 2B6, 2C9, 2Å1, accelerate aminopyrine, 7-ethoxyresorufine, 7-pentoxyresorufine, aniline and androstendione oxidation. Activity of benzobarbital and fluorbenzobarbital as inductors is to a large degree due to the action of their major metabolite — phenobarbital. Benzobarbital and fluorbenzobarbital unlike phenobarbital induce isoenzyme 3A4, responsible for androstendione 16b-OH-hydroxylation. PCN-type induction activity posses also native molecules of benzobarbital and fluorbenzobarbital.
Antioxidant and antiradical properties of polyphenols in the mechanism hepatoprotective actions of preparations Maackia amurensis
Authors: Ratkin Ye. V. , Ivanov V. V. , Ratkin A. V. , Chuchalin V. S.
Published: June 2020

For finding-out of a role antioxidant and antiradical properties of poly-phenols in mechanisms hepatoprotective actions of preparations from Maackia amurensis activity of preparations from ядровой wood (Macsar), an extract of cellular culture Maackia amurensis, stilbens. Antiradical properties of preparations measured on ability to cooperate with difenilpikrilgidrazilom (DPPH). It is established, that for Macsar, PKMA, monomeasured and dimeric Stilbenes is absent correlations between antiradical activity of the given preparations from a polyphenolic complex Mauck Amur in modelling system with DPPH and them hepatoprotective effect in vivo. Monomeasured and dimeric stilbenes, possessing the highest antiradical activity appreciated on their ability to restore stable radical DPPH, have not shown expressed hepatoprotective activity at a hepatites.
Interaction of Pinostrobin Oxime and Leukomizin with reactive oxygen species in model systems
Authors: Rodnova Ye. A. , Ivanov V. V. , Chuchalin V. S. , Melentiyeva A. N. , Arystan L. I. , Shulgau Z. T. , Adekenov S. M.
Published: June 2020

Free radical processes are a common universal mechanism of cellular damage in the pulmonary and cardiovascular diseases, diseases of the pancreas and liver, atherosclerosis, cataracts, etc. In this work, we investigated the interaction of the pinostrobin oxime and leucomisine with active forms of oxygen. The study of the interaction of the pinostrobin oxime and leucomisine with a stable radical 2,2-diphenyl-1-picrylhydrazyl, superoxide anion radical, hydroxyl radical, and the effects on stimulated prooxidants (hydrogen peroxide) lipid peroxidation in post-nuclear fraction of liver. As comparison drugs used substances with known antioxidant and antiradical activity - butylated hydroxytoluene, quercetin, and mannitol. The experiments showed that pinostrobin oxime and leucomisine exhibit moderate antiradical activity against the studied free radicals.
Influence of air flow interruption on the total nonelastic resistance of respiration
Authors: Bodrova T. N.
Published: June 2020

The total nonelastic work of respiration (TNWR) was studied in 18 healthy people and 11 patients with the chronic obstructive pulmonary disease with the aid of simultaneous recording of transpulmonary pressure and volume. It was found that under the conditions of identical pulmonary minute volume at air flow interruption by valve, TNWR becomes larger compared to that at quiet deep breathing. The additional resistance was called acophased and was considered as a manifestation of independent mechanical pulmonary activity.
The morphological characteristic of chorion villi in early terms of pregnancy in the presence of urogenital infection
Authors: Mustafina L. R. , Khon Ye. V. , Logvinov S. V. , Yuriyev S. Yu.
Published: June 2020

The morphological structure of the chorion villi in I trimester of pregnancy is studied at ureaplasmas and mycoplasmas infections. Established signs of the accelerated maturing of the villi, strengthened proliferation of trophoblast, increased of stromal and vascular components of chorion have been revealed.
Characteristics of induced sputum neutrophils and macrophages in patients with chronic obstructive pulmonary disease on a basic therapy
Authors: Fedosenko S. V. , Chernogoryuk G. E. , Kirillova N. A. , Fisenko A. Yu. , Roslyakova Ye. P.
Published: June 2020

Aim of the research — to define the tiotropium bromide influence on bronchial neutrophiles and macrophages morphofunctional properties at stable of chronic obstructive pulmonary disease (COPD). The tiotropium using for 3 months has allowed to improve essentially qualitative characteristics of key effectors cells. The revealed changes were observed in all groups of patients irrespective of a previous mode of COPD treatment.
Surgical treatment of stable tracheo-laryngeal defects in patients with chronic stenoses of the larynx and trachea
Authors: Simonov S. V.
Published: June 2020

Despite of the obvious progress in posttraumatic larynx and trachea stenosis’s treatment during the last time surgical therapy of the laryngotracheostoma is still urgent issue. A tracheostoma’s plastic closure is fundamental and terminal method in treatment such diseases, this findings are confirmed by the literature review. To conduct such a treatment nowadays best methods and transplant materials are looked for.
Molecular and epidemiological basis of cow's milk allergy
Authors: Fedotova M. M. , Ogorodova L. M. , Fyodorova O. S. , Evdokimova T. A.
Published: June 2020

Allergy to cow's milk is characterized by early onset and high prevalence in pediatric population. The review presents current data on the molecular structure, physicochemical and allergenic properties of the cow's milk proteins. The patterns of the natural history of cow's milk allergy are described. The aspects of the development of tolerance to the proteins of this product are performed.
The role of galectin-1 in the T-lymphocytes homeostasis
Authors: Yakushina V. D. , Vasiliyeva O. A. , Ryazantseva N. V. , Novitsky V. V. , Chechina O. Ye. , Prokhorenko T. S. , Starikova Ye. G.
Published: June 2020

Fault in T-lymphocytes homeostasis leads to different diseases with poor or vise versa strong immune response. So it seems to be interesting to research molecules of T-cell cooperation to develop new more effective therapeutic methods. Important factor modulating T-cell activity is galectin-1 which takes part in multiply process of cell biology — regulation of cell maturation, migration, signal transduction, functional ability and apoptosis.
INFLUENCE OF VARIOUS METHODS OF POSTOPERATIVE ANESTHESIA ON THE STATUS OF HAEMOSTASIS SYSTEM IN HIP REPLACEMENT
Authors: Borin V. V. , Shipakov V. Ye. , Karmanov I. M. , Kukovyakin A. A.
Published: June 2020

120 patients were examined using instrumental methods, such as hemocoagulography and agregatography. It has been various methods of postoperative anesthesia have different effect on the functional status of haemostasis system following hip replacement. Optimization of postoperative anesthesia provides a way of preventing thrombohemorrhagic complications
CHARACTERISTIC OF RESISTANCE OF ERYTHROCYTES IN CARDIOSURGICAL PATIENTS WITH VARIOUS DEGREE OF MANIFESTATION OF POSTPERFUSION HEMOLYSIS
Authors: Maltseva I. V.
Published: June 2020

The resistance of red cells to the mechanic, osmotic, and acid factors, as well as the permeability of red-cell membrane to low-molecular hydrophilic substances in patients with ischemic heart disease (IHD) with moderate (24 patients) and pronounced (13 patients) hemolysis after surgery under conditions of cardia bypass has been studied. It is found that the development of pronounced hemolysis (in contrast to the moderate one) is associated with the high permeability of the red-cell membrane before surgery at the reduced acid and mechanic resistance of cells, which decreases after surgery and combines with normalization of acid resistance of red cells with the red-cell membrane permeability kept at the initially high level. The osmotic resistance of red cells in IHD patients is increased regardless of the level of hemolysis and the stage of the study, and its minimal level is observed only in patients with moderate hemolysis before surgery.
BIOTECHNICAL SYSTEM TO GENERATIONS EEG LIKE SIGNAL
Authors: Pyatakovich F. A. , Makkonen K. F. , Yakunchenko T. I.
Published: June 2020

The Purpose – realization of the structure specialized biooperated module to generations EEG-like signal directed on personalization and reinforcement to efficiency of the treatment. In work are used methods of modeling, system technical analysis and constructing.The conclusion: Its were designed models of the formulas of the action, which provide presenting on electrodes for stimulation modulated current by means of signal of the pulse and breathings within the range of changeable frequencies 7–13–7 Hz or 14–26–14 Hz.
BIOFEEDBACK IN MIGRAINE TREATMENT
Authors: Starikova N. L.
Published: June 2020

Purpose: to investigate determinants of biofeedback efficacy in migraine. 50 migraine patients were included. MIDAS questionnaire, Spielberger’s and Beck’s questionnaires, Vanderbielt’s inventory, generic and migraine-specific quality of life questionnaires were used. Conclusion: biofeedback efficacy doesn’t depend on anxiety and depression scores prior to treatment, but correlate with active coping-strategies scores.
ABILITY TO SELF-CONTROL IN BIOFEEDBACK GAMES AND SUCCESS OF PUPILS OF 11–13 YEARS
Authors: Gileva O. B.
Published: June 2020

The relation of indicators of biofeedback and the school success was studied. The relation of pulse interval, wave structure of heart rate, Sacred George's index (StGe) and progress of children is found out. Results are discussed with relations of use of computer biofeedback games for studying of psychophysiological features and predictors of school success.
APPLICATION OF EEG FEEDBACK FOR THE CORRECTION OF PSYCHOEMOTIONAL STATE OF CHILDREN
Authors: Eismont Ye. V. , Aliyeva T. A. , Lutsyuk N. V. , Pavlenko V. B.
Published: June 2020

Evaluated the efficacy of neurofeedbacktherapy to normalize the psychoemotional state of children. Trained parameters of EEG were the amplitude of alpha-rhythm, the ratio of amplitudes of alphaand theta-rhythms, sensorimotor and theta-rhythms. In the experimental group showed an increase in the trained parameters of the electroencephalogram, reduced anxiety, “feelings of inferiority” and improvement of voluntary attention. The results indicate the feasibility of neurofeedbacktherapy to optimize the psychoemotional state of children.
CHANGES OF VARIABILITY HEART RATE INDEXES DURING NEUROFEEDBACK IN DIFFERENT QUALIFICATION SPORTSMEN
Authors: Cherapkina L. P.
Published: June 2020

The increasing of total heart rate spectral power and parasympathetic activity (by indexes of the variation pulsomeasuring) during neurofeedback sessions intended for electroencephalogram (EEG) power in alpha-band increasing in masters of sport, master of sport of international level (n = 26), candidates to master of sport (n = 25) and sportsmen of lower qualification (n = 23) were accompanied by different changes of structure of heart rate spectral.
INFLUENCE OF ALPHAEEG/EMG BIOFEEDBACK AND SELF-REGULATION PSYCHO TECHNIQUES ON THE HEART RATE VARIABILITY INDICES
Authors: Bazanova O. M. , Vernon D. , Muravlyova K. B. , Skoraya M. V.
Published: June 2020

With the purpose to study the impact of the upper frequency alpha EEG power increasing neurofeedback training (ANFT) on the cognitive performance, EEG alpha-activity and heart rate variability (HRV) 27 healthy men aged 18–34 years in pre, post and follow up one month 10 sessions ANFT time were investigated. The AFNT enhanced the fluency in cognitive performance, alpha frequency and power in upper frequency range and HRV only in participants with low baseline alpha frequency. While mock AFNT did change neither cognitive performance, nor alpha-activity, nor HRV indices. ANT reduces activation in cognitive load, and this effect persists for a month.
PSYHOPHYSIOLOGICAL AND PSYCHOLOGICAL DIFFERENTIAL DIAGNOSTICS OF THE IDENTITY STRESS SUBJECT
Authors: Kivorkova A. Yu. , Ahverdova O. A. , Voloskova N. N.
Published: June 2020

The article is considering psyhophysiological and psychological differential diagnostics of the identity stress subject. Psyhophysiological diagnostics using biofeedback technology is presented with software complex “BOSLAB”. Psychological diagnostics is presented in constitutional-psychotypological continuum of the personality.
THE MECHANISMS OF STRESS REACTIONS BY PERSONS OF DANGEROUS PROFESSIONS: METHODOLOGY OF PSYCHOPHYSIOLOGICAL RESEARCH
Authors: Tishakin D. I.
Published: June 2020

In this article we are describe an experimental research dedicated to study of psychophysiological mechanisms of self-regulation by persons of dangerous professions. The study was conducted on a group of cadets of the military university. The methodology base includes the methods of psycho-diagnostics, psychophysiological testing, and specially designed protocols of stress-testing are modeled the stress situation. There short analysis of performed experiment is given by psychophysiological research position also conducts in article.
RESPIRATORY FUNCTION RECOVERY OF THE POSTSURGICAL PATIENTS BY MEANS OF THE BIOFEEDBACK OF THE CARBON DIOXIDE CONCENTRATION IN EXHALED AIR AND RESPIRATORY RATE
Authors: Brazovskaya N. G. , Melekhin Ye. V. , Svetlik M. V. , Brazovsky K. S. , Vusik A. N.
Published: June 2020

The methodical, technical and software realization of the biofeedback of expiration parameters are described. The biofeedback training method based on the breath frequency and CO2  concentration regulation is proposed. Preliminary study was conducted in the group of patients after abdominal surgical. It has been shown that the patients master their skills of CO2  concentration self-regulation. Using biofeedback for the postsurgical rehabilitation facilitates the rapid recovery of the expiration parameters.
EXPERIENCE OF BIOFEEDBACK IN CLINIC OCCUPATIONAL DISEASES
Authors: Dyakovich M. P. , Kazakova P. V. , Shevchenko O. I. , Sudakova N. G. , Rusanova D. V. , Kartapoltseva N. V. , Katamanova Ye. V.
Published: June 2020

Biofeedback in toxic encephalopathy in the late period chronic intoxication by mercury and complex toxic substances led to decrease in the EEG changes, performance improvement of the amplitude and latency evoked potentials, in vibration disease – to decrease manifestations of angiodystonia syndrome, recovery of neuromuscular conductivity. The effectiveness of biofeedback is confirmed by changes in subjective measures of the patients.
ANALYSIS OF A DIFFERENTIATED APPROACH TO THE APPOINTMENT OF DICK METHODS IN BIOFEEDBACK CORRECTION AUTONOMIC DYSFUNCTION
Authors: Polyakova A. G. , Matveeva V. V.
Published: June 2020

Goal of research: analysis of the effectiveness of Biofeedback therapy is differentiated depending on the clinical forms of autonomic dysfunction. Exchange rate control efficacy of biofeedback hardware was conducted on the dynamics of clinical andl aboratory data, surveys and assessment of the functional State of the SNC using heart rate variability, vegetative resonance test, Kerdo index definition, as well as èlektrokardiografiče applications and questionnaires, characterizing the State of psychoemotional sphere (Spilbergera–Hanina, test, Luscher). Laboratory tests include a complete blood count with evaluation of Adaptive reactions of the organism. The results of the rehabilitation complex of the patients with the use of biofeedback have confirmed its effectiveness.
LEXICAL COMPETENCE AS THE LANGUAGE BASIS OF MEDICAL STUDENTS’ COMMUNICATIVE COMPETENCE
Authors: Starodubtseva O. G.
Published: June 2020

The article is devoted to questions of the formation of foreign-language lexical competence as the language basis of Medical students’ communicative competence, the main concepts relating to the lexical aspect of foreign language training are interpreted, the attention is paid to the lexical component as the most essential one of both expressional and receptive types of speech activity, levels of the formation of lexical competence as necessary stages of its gradual development are shown. The author pays attention to lexical skills as the integral structural component of foreign-language professional lexical competence in a framework of interdisciplinary connections characterizing their features and conditions of its development, the advantage of lexical competence formation on an interdisciplinary basis is pointed out while taking into consideration the linguistic features of the language material and also applying the results of students’ educational activity.
PANCREATIC AND EXTRA-PANCREATIC EFFECTS OF INCRETINS AND PERSPECTIVES FOR STUDYING ENTEROINSULIN HORMONAL SYSTEM DURING GESTATIONAL DISORDER OF CARBOHYDRATE METABOLISM
Authors: Saprina T. V. , Timokhina Ye. S. , Musina N. N. , Prokhorenko T. S. , Tashireva L. A. , Goncharevich O. K.
Published: June 2020

The absence of an ideal medicine for the treatment of patients with type 2 diabetes, that would be able to provide not only high quality and constant monitoring of glycemia without increasing body weight, with no risk of hypoglycemia, with no negative impact on the heart, kidneys, liver, but could also ensure the preservation of the secretory function of β-cells, makes scientists continue to search for new opportunities to influence the occurrence and progression of T2D.Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the two primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic β-cells. Within the pancreas, GIP and GLP-1 together promote β-cell proliferation and inhibit apoptosis, thereby expanding pancreatic β-cell mass, while GIP enhances postprandial glucagon response and GLP-1 suppresses it. In adipose tissues, GIP but not GLP-1 facilitates fat deposition. In bone, GIP promotes bone formation while GLP-1 inhibits bone absorption. In the brain, both GIP and GLP-1 are thought to be involved in memory formation as well as the control of appetite. In addition to these differences, secretion of GIP and GLP-1 and their insulinotropic effects on β-cells have been shown to differ in patients with type 2 diabetes compared to healthy subjects.Enteroinsulin hormones' role in the development of gestational disorder of carbohydrate metabolism is poorly understood.In a review article we analyze the publications that summarize what is known about the pancreatic and extra-pancreatic GIP and GLP-1-effects compared with healthy subjects and type 2 diabetes patients. The aspects of gestational diabetes pathophysiology and the perspectives for studying enteroinsulin hormonal system during pregnancy are also discussed in the article.
STUDING OF SUDDEN DEATHS IN MOSCOW
Authors: Elin D. V.
Published: June 2020

In this retrospective study, we report the frequency and main causes of sudden deaths in Moscow over 3year period. Frequency of sudden death is 78 134 cases. Males were 63.0% of cases. The incidence of sudden death was highest in the 2 age extremes (39% were 40–59 year old and 57.5% were elderly). The most important direct causes of sudden death were cardiovascular diseases (93%). 15% of outpatient medical records were filled in the course of pronouncement of death. A divergence in diagnosis occurred in 45.1 % of cases.
NORMAN HOLTER AND HIS METHOD OF REMOTE CARDIOLOGIC MONITORING. CASE HISTORY
Authors: Rassadina A. A. , Tarakanov S. A. , Kuznetsov V. I.
Published: June 2020

This publication is devoted to the personality and creative designs of uncommon American scientist, the engineer and the inventor – Norman Jefferis «Jeff» Holter. Norman Jefferis Holter introduced the terminology of «nuclear medicine» for the name of the new at that time area which associated with employment of the achievements of the nuclear physics in the medical goals. Also he is the author of ambulatory cardiological monitoring.
REFLECTION SPECTRA OF SKIN IN VITILIGO
Authors: Zhulmina V. V. , Brazovsky K. S. , Pesterev P. N. , Kologrivova Ye. N. , Labzovskaya N. P.
Published: June 2020

Vitiligo is a disease with unknown etiology, which is characterized by skin depigmentation areas due to melanocyte death. Lack of clear understanding of pathogenic disease processes justifies the difficulty of choosing efficient treatment methods. Repigmentation is slow and not always complete. One of the key indicators in practical dermatology is objective assessment of skin cover condition for further diagnostics, definition of therapy and dynamics of the disease.The purpose of this study is to assess skin reflection spectrum in depigmentation areas, marginal layer and visible healthy skin before and after treatment of patients with vitiligo.21 patients having vitiligo were under observation; the patients were treated in the hospital of skin and venereal diseases of the Siberian State Medical University. The authors applied noninvasive method of spectrophotometry for the first time in order to study skin reflection spectrum of patients with vitiligo. Noninvasive medical spectrophotometry is based on dependence factor of integral optical properties of biological tissues and fluids in the conditions of homeostasis and in case of pathology. In order to assess the efficiency of skin disease treatment the patients were exposed to skin spectrophotometry before the beginning of the treatment and after the treatment itself with further measurements of the reflection spectrum integral criteria. The measurements were made in depigmentation area, on the boundary with healthy skin and in remote from depigmentation area of healthy skin.Obtained results indicate the difference of skin reflection spectra in the areas under investigation. Moreover, positive dynamics of the treatment associated with the decrease in the value of reflection spectrum integral criteria in the diseased area. There were no statistically important differences of the integral criteria, calculated based on measurement results of reflection spectra on the boundary of depigmentation area before and after treatment. Most likely this is related to active processes of repigmentation in the skin in the course of the treatment.For detailed study of identified phenomena there is a need for thorough study and expansion of the list of dermatologic diseases.
MITOCHONDRIAL PROTEIN PROFILE AND ITS ROLE IN PATHOLOGIC PROCESSES
Authors: Kosterina Ye. A. , Kozenkov I. I. , Kasymov V. A. , Kamensky P. A. , Dominova I. N. , Korolyova Yu. A. , Patrusheva V. Ye. , Bogachev R. S. , Litvinova L. S. , Babak S. V. , Moiseeva Ye. M. , Bogdanov Ye. A. , Mukhortova O. A. , Vavilina Ya. S. , Mikhalchenkova T. A. , Patrushev M. V.
Published: June 2020

Mitochondria import hundreds of different precursor proteins from the cytosol, and only 13 proteins are encoded by mtDNA itself. Recent investigations demonstrated real size of mitochondrial proteome and complexity of their functions There are many methods using for mitochondrial proteome profiling, that help to understand a molecular mechanisms of mitochondrial functions and identify the causes of disruptions that lead to different disorders. In this review we discuss a recent data in the field of mitochondrial proteomics.
EFFECT OF NEURODEGENERATIVE CHANGES IN THE BRAIN ON THE FORMATION OF THE DISEASE CLINICAL PICTURE IN PATIENTS WITH MULTIPLE SCLEROSIS
Authors: Prakhova L. N. , Magonov Ye. P. , Ilves A. G. , Bogdan A. A. , Kataeva G. V. , Malakhova Ye. S. , Savintseva Zh. I. , Stolyarov I. D. , Trofimova T. N.
Published: June 2020

The aim of the study was to determine the relationship of global and regional cerebral atrophy and volume of demyelination lesions in the brain with a clinical picture in patients with multiple sclerosis (MS). The study involved 55 patients with MS. Control group included 22 healthy volunteers. Patients were divided into groups according to the severity of disability, the type and duration of disease. Assessment of general and regional atrophy was performed by post-process volumetric segmentation of MRI data, which was acquired at 3T Philips Achieva scanner. The post-processing was done with the FreeSurfer software. It is shown that in MS patients brain atrophy develops both by means of gray matter (including the cortex and subcortical structures), and white matter, along with demyelination. Global and regional atrophy is associated with the severity of disability of patients according to EDSS scale, but not with the duration and type of the disease. Neurodegenerative changes of brain structures evolve with different rates, have different intensity and determine the set of symptoms of neurological impairment and severity of disability, which indicates the presence of certain patterns of the process of atrophy in the brain, forming the clinical picture of the disease.
DIAGNOSTIC OPPORTUNITIES OF NEUROOPHTHALMOLOGIC INSPECTION AT RS: ROLE OF AN OPTICAL COHERENT TOMOGRAPHY AND THE VISUAL CAUSED POTENTIALS IN EARLY DIAGNOSTICS OF MULTIPLE SCLEROSIS AND MONITORING OF A CONDITION OF THE VISUAL ANALYZER AT PATIENTS WITH VARIOUS OPTIONS OF MULTIPLE SCLEROSIS
Authors: Andreyeva Ye. A.
Published: June 2020

Examination of 70 patients with different options of a course of multiple sclerosis is conducted. Reliable decrease in thickness of a layer of a neuroepithelium and macular volume of a retina at patients with various options of a course of the multiple sclerosis, more expressed is noted at primary progressing and secondary progressing current options, and the patients who have transferred an optical neuritis. The functional violations at the level of an optic nerve according to the visual caused potentials – increase in a latence and decrease in amplitude of the P100 component are revealed. Possibility of application of methods of an optical coherent tomography and the visual caused potentials for diagnostics and monitoring of pathological process is shown at multiple sclerosis.
LEBER'S DISEASE. CLINICAL CASE
Authors: Maslova N. N. , Andreyeva Ye. A. , Yerokhina Ye. V.
Published: June 2020

Violation of visual functions and oculomotor frustration develop at 90% of patients with MS. More than a half of patients are transferred by the numerous recurrence of an optical neuritis which is coming to an end with a partial atrophy of optic nerve. For well-timed purpose of pathogenetic treatment differential diagnostics with other diseases, being accompanied an atrophy of an optic nerve, in particular with Leber's disease.
ATYPICAL FORMS OF MULTIPLE SCLEROSIS IN THE TOMSK REGION
Authors: Alifirova V. M. , Titova M. A. , Terskikh E. V. , Musina N. F.
Published: June 2020

The study involved 280 patients aged 10 to 70 years old with a valid diagnosis of multiple sclerosis according to the McDonald criteria. There  are 6 (2.1%) patients had the first manifestation of disease overthe age of 45, 18 (6.4%) – 20 years earlier. In 7 (2.5%) of patients diagnosed with malignant progressof the MS, in 30 (10.7%) – soft progress.
COMPLEX NEUROPHYSIOLOGICAL DIAGNOSTICS OF THE COMPLICATED TRAUMA OF CERVICAL DEPARTMENT OF A BACKBONE DURING THE SHARP PERIOD
Authors: Vstavskaya T. G. , Larkin V. I. , Katina M. M.
Published: June 2020

The acoustic deckman and somatosensorny caused potentials at 65 patients with the complicated trauma of cervical department of a backbone are investigated. It is established that the complicated trauma of cervical department of a backbone leads to functional violations at level of cervical segments of a spinal cord and deckman structures of a brain. Existence of functional changes is influenced by weight of damage of a spinal cord and degree of instability of vertebras.