bluuebunny/crossref_metadata_2025 huggingface dataset:
Decisions of Izmir Economics Congresses: An Interpretive Content Analysis
Authors: TUTAR Hasan , ÖZKAN Neslihan
Published: October 2023

This study aims to analyze the interpretive content of the issues emphasized and prominent in the decisions taken in the Izmir Economic Congress held so far by using the Voyant Tools program. The exploratory study is conducted according to the interpretive content analysis technique. In the study, the texts of the decisions taken in Izmir Economics Congresses were determined by an online convenient sampling technique. In the study, the decisions taken in Izmir Economics Congresses were analyzed with the help of the Cyrrus Tool, Reader tool, Trend tool, Summary tool, and Context tool offered by Voyant Tools online program. All five mentioned tools are tools with scalable parameters. The numerical findings obtained from the analysis were presented and interpreted together with the visuals. The five text analysis tools used in the analysis process are understood to provide essential information depicted in visualization formats. The findings are interpreted together with the context of the visualized data, delivering powerful clues for reaching accurate conclusions. The results of the analysis show how different input parameters affect the study. The prominent themes in the results of the research are essential in terms of showing what the basic vision of the Republic of Turkey is in the decisions taken at the Izmir Economic Congresses.
Development of Animated Video Learning Media for Energy Saving Behavior at Robbani Tutoring in Ogan Ilir Regency
Authors: Ahmania Ayunda , Husin Azizah , Nurrizalia Mega
Published: October 2023

The aim of this research is to develop learning media for animated videos of energy saving behaviour at Robbani Tutoring in Ogan Ilir Regency. The model suggested by Thiagarajan in terms of defining, designing, developing and disseminating (the 4-D model) is used as a development model. The data were collected by means of questionnaires and interviews. The results of this study indicate that validation from linguists obtained a percentage score of 88.8% with a very feasible category, media experts obtained a percentage score of 90% with a very feasible category, and material experts obtained a percentage score of 97% with a very feasible category. The results of one-to-one trial showed an overall percentage score of 79% with a very practical category and the same was true for the small group trial, which scored 89% in that category. Therefore, it is considered that it is feasible and practical to use the animated video product of energy saving behaviour as a learning media in science subjects for students to learn about energy saving behaviour.
Highest Education Smartphones Use and It’s Relationship with Students Engagement
Authors: Fitria Jihan , Mariono Andi , Maureen Irena Yolanita
Published: October 2023

This study aims to explain the influence of smartphones on student engagement in state university students in the city of Surabaya. This study used 85 total samples. This type of research is quantitative research using survey methods with the following stages; observation of research locations, preparation of questionnaires, distribution of questionnaires, validity testing, data collection, processing of research results, analysis of research results, discussion. The results showed that the influence of smartphones on student engagement was 0.057 or 5.7% with a significance of 0.028 <0.05. Test results t-table is greater than t-count, i.e. t-count = 2.232 ≥ (t-tab) = 1.989. it can be proven that there is a variable influence of smartphone use on student engagement in state university students in the city of Surabaya. This can be proven from the results of the t test, namely t count 2.232 greater than table 1.989 with a significance level of 0.028. This means that there is an influence on smartphone use on student engagement. Furthermore, when reviewed from the results of the Model Summary table on the R test square scored a coefficient of determination of 0.057 or 5.7%. This means that the variable smartphone use (X1) has a contributing influence on student engagement (Y) by 5.7% and the other 94.3% is influenced by other variables outside the variable of smartphone use.
Development of LKPD Based on Discovery Learning on Human Respiratory System Material to Train Skills Student Critical Thinking
Authors: Fauziah Siti , Khairuna Khairuna , Reflina Reflina
Published: October 2023

LKPD (Student Worksheet) based on discovery learning  is intended to provide learning knowledge directly in the process of meaningful learning activities so as to direct students to find learning concepts. This study aims to determine the level of feasibility, practicality and effectiveness of LKPD based  on Discovery Learning to train students' critical thinking skills on respiratory system material. Researchers used the R&D (Research and Development) method  using a 4-D development model (Define, Design, Development and Desemminate) developed by S. Thiagarajan, Dorothy S. Semmel, and Melvyn I. Semmel in 1974. The test subjects in the study consisted of 36 students from class XI IPA SMA PAB 4 Sampali. The results showed that the feasibility value of developing LKPD from material experts was 86.1% with the very feasible category and LKPD experts by 75% with the feasible category. Then the percentage of practical scores for LKPD development from biology teachers and students of science XI was 82.14% and 83.47% respectively with the practical category. The effectiveness of LKPD development based on individual completeness from  the pre-test  and post-test students obtained an average N-Gain  score of 62.14, so the use of the method has been effective because the N-Gain normality value obtained between 0.30 < g < 0.70 with the "effective" criterion. Then for the N-Gain score value of 0.62, this value is in the medium category because the N-Gain score is between 0.3-07 with the category "medium N-Gain". From the overall results including valid, practical and effective categories, it can be concluded that LKPD based  on Discovery Learning on the equipment system material is suitable for use and distribution to PAB 4 Sampali High School.
Hair Disease Classification Using Convolutional Neural Network (CNN) Algorithm with VGG-16 Architecture
Authors: Karo Karo Ichwanul Muslim , Kiswanto Dedi , Panggabean Suvriadi , Perdana Adidtya
Published: October 2023

Hair diseases are common and can be caused by a variety of factors, including genetics, stress, nutritional deficiencies, as well as exposure to sunlight and air pollution. Accurate diagnosis of hair diseases is important for proper treatment, but can be challenging due to overlapping symptoms. The development of the healthcare world has widely utilized machine learning and deep learning approaches to assist in the healthcare field. This research aims to develop hair disease classification using Convolutional neural network (CNN). The CNN-based approach is expected to help health professionals diagnose hair diseases accurately and provide targeted treatment. This research involves an experimental design with three main stages: identifying the research problem, conducting a literature review, and collecting data. The research uses a dataset of hair disease images obtained from Kaggle, which are annotated and organized based on different hair disease types. After the image data is collected, the image dataset will go through the image preprocessing stage. Experiments were conducted using hair disease image data with 15 epochs on a CNN Deep Learning model with VGG-16 architecture, and resulted in an accuracy of 94.5% and a loss rate of 18.47%, with a testing epoch time of 9 hours 48 minutes. The results of this study show that CNN with VGG-16 architecture can successfully classify 10 types of hair diseases
Cumhuriyet Türkiyesi Anayasalarının Osmanlı Kökleri: Fatih’in Teşkîlat Kanûnnâmesi’nden (Kanûnnâme-i Âl-i Osman) Gülhane Hatt-ı Hümâyûnu’na Anayasal Hareketlere Genel Bir Bakış
Authors: Eraslan Zeki
Published: October 2023

Osmanlı Devleti’nde Fatih’ten itibaren kamu hukukunda önemli düzenlemeler söz konusudur. Devletin sağlam temeller üzerine nasıl inşa edilebileceği sorunu bazı kanuni düzenlemelerin gerekliliğini ortaya koymuştur. Fatih’in Teşkîlat Kanûnnâmesi/Kanûnnâme-i Âl-i Osman bu çerçevedeki düzenlemeleri bir araya getiren ilk kodifikasyondur. Ancak bahsi geçen kanunun bir anayasa olup olmadığı noktasında tam bir uzlaşının bulunmadığı görülmektedir. Diğer taraftan Osmanlı Dönemi anayasal gelişmeleri ve anayasaları üzerine yapılan çalışmaların kısıtlı yönü bu meselede de kendini göstermektedir. Tarihsel süreçte anayasal gelişmelerde birer kilometre taşı olmuş adımların mukayeseli bir analize tabi tutulması ise daha da az rastlanan çalışma yöntemi olarak karşımıza çıkmaktadır. Bunun en önemli sebeplerinden birinin bu tür çalışmaların disiplinler arası mahiyeti gereği taşıdığı zorluklar olduğu düşünülmektedir. Bu bağlamda Osmanlı Anayasa Tarihi çerçevesinde ele alınacak oldukça önemli gelişmeleri, öncelikle kendi içerisinde daha sonra da mukayese etmek suretiyle ele almanın alana özgün bir katkı sağlayacağına duyulan inanç bu çalışmanın hareket noktası olmuştur.
Fatih’in Teşkîlat Kanûnnâmesi’nin bir anayasa olduğuna ilişkin tespitler söz konusu olmakla birlikte ilk anayasayı 1876 Kanûn-ı Esâsî ile başlatmak daha yaygın ve isabetli bir yaklaşımdır. Ancak ilim dünyasında bu yaygın yaklaşımın sahipleri tarafından Fatih’in Teşkîlat Kanûnnâmesi’nin neden bir anayasa olarak değerlendirilemeyeceği hususunun pek tartışılmadığı görülmektedir. Fatih’in Teşkîlat Kanûnnâmesi şeklî ve maddî açıdan ele alındığında bir anayasa olarak nitelendirilemeyeceği sonucuna varılmıştır. Diğer taraftan Fatih’in Teşkîlat Kanûnnâmesi’ne nazaran çok daha fazla anayasal nitelik içeren Gülhane Hatt-ı Hümâyûnu’nun da anayasal bir gelişme olmakla birlikte bir anayasa olarak nitelendirilemeyeceği açıktır. Ancak Gülhane Hatt-ı Hümâyûnu, modern anayasaların yer verdiği pek çok temel hak ve hürriyete yer verdiği gibi bunları güvence altına alan mekanizmaları da kurmaya çalışmıştır. Çalışmada, tarihsel tekâmül sürecinde Cumhuriyet Türkiyesi’ne tevarüs eden ve günümüz anayasalarını da belli düzeyde etkileyen Osmanlı anayasal gelişme sürecinin önemli kilometre taşlarına birinci elden kaynaklar dikkate alınarak ışık tutulması hedeflenmiştir.
Pengembangan Modul Elektronik ‘Flipbook’ Sebagai Bahan Ajar Pengayaan Keterampilan Menulis Bahasa Inggris
Authors: Firdaus Ghea Suramita , Hartatik Sri Fatmaning
Published: October 2023

Penelitian dan Pengembangan ini dilakukan karena analisis kebutuhan menunjukkan bahwa penggunaan materi e-learning di SMPN 13 Malang belum diterapkan. Peneliti menggunakan prosedur penelitian dan pengembangan dengan prosedur yang dimodifikasi dari Borg and Gall. Instrumen dalam penelitian ini adalah rubrik penilaian validasi terkait materi dan desain produk, angket, dan lembar observasi penggunaan produk. Data yang terkumpul dikelompokkan menjadi dua, yaitu data kuantitatif dan kualitatif. Data kualitatif diperoleh dari tanggapan para ahli, angket, dan lembar observasi penggunaan produk yang dibaca secara menyeluruh, dikelompokkan, dan diinterpretasikan. Interpretasi tersebut kemudian dibandingkan dan dikontraskan dengan ilmu yang ada. Sedangkan data kuantitatif akan dianalisis dengan menggunakan perhitungan rata-rata. Hasil penelitian menunjukkan bahwa ahli materi memberikan penilaian akhir dengan rata-rata 3,20 dan menempatkan produk pada kategori valid. Demikian pula, ahli media juga mengklaim produk flipbook keterampilan menulis Bahasa Inggris yang dikembangkan sebagai produk valid dengan memberikan skor rata-rata 3,80. Lebih lanjut, hasil angket respon siswa menunjukkan bahwa 92.8% siswa mengakui bahwa flipbook yang dikembangkan membuat mereka termotivasi dalam pembelajaran keterampilan menulis karena produk ini tidak hanya menyajikan materi tetapi juga gambar-gambar menarik serta video yang bermakna. Mereka juga menyatakan bahwa flipbook juga ramah pengguna karena dapat diakses dengan mudah dari ponsel mereka. Selain itu, hasil uji coba dengan nilai rata-rata 89,10 menunjukkan bahwa produk ini tidak hanya meningkatkan minat siswa tetapi juga meningkatkan keterampilan siswa.
Analisis Makna Narit Maja Berdasarkan Bidang Agama dan Adat Istiadat dalam Masyarakat Bireuen
Authors: Furqan Al , Wulanda Wulanda , Isnani Wirdatul , Rizki Azrul
Published: October 2023

Penelitian ini bertujuan mengkaji makna narit maja berdasarkan bidang keagamaan dan adat istiadat dalam masyarakat Bireuen. Data narit maja diperoleh dari tuturan masyarakat Bireuen dan buku Narit Maja Aceh. Data dianalisis dengan pendekatan kualitatif dengan metode cakap dengan teknik pancing, sadap, catat, dan rekam serta kaji dokumen. Hasil penelitian adalah sebagai berikut. (1) dalam masyarakat Bireuen masih dilestarikan satra lisan berupa narit maja atau peribahasa sarana untuk menasehati, menegur, dan memberikan pelajaran berharga bagi masyarakat; (2) dalam hasil penelitian ditemukan sepuluh peribahasa yang diturukan masyarakat dalam bidang keagamaan. Makna yang terkandung dalam peribahasa tersebut bermakna tentang kehidupan sosial keagamaan yang tujukan sebagai nasihat, hanya satu peribahasa yang ditujukan untuk menegur dengan kata yang kasar; (3) peribahasa yang bereveren adat istiadat terdapat enam contoh peribahasa yang sering dituturkan masyarakat. Peribahasa yang bereveren adat istiadat di dalamnya banyak yang berisi pedoman hidup tentang memuliakan tamu, menjaga adat, menjadi pribadi yang baik dalam masyarakat dan tidak iri atas pencapaian orang lain. Pada peribahasa yang bereveren adat istiadat juga terdapat makna yang menegur dan mencela; (4) secara umum makna peribahasa yang berkembangan dalam tuturan masyarakat Bireuen berisi tentang nasihat keagamaan dan pedoman bagi manusia untuk menjalankan hidup sehari-hari dalam masyarakat.
Data-driven innovation of left ventricular assist device therapy
Authors:   , Numan Lieke
Published: October 2023

Heart failure is a global and growing problem that affects 1-2% of people. For patients with end-stage heart failure, a heart transplant is the “gold standard”. Due to the permanent shortage of donor hearts and a growing number of patients on the transplant waiting list, treatment with a left ventricular assist device (LVAD) has become increasingly important.
Survival of patients after LVAD implantation has improved significantly over the past two decades. Nevertheless, patients frequently suffer from important complications such as strokes, driveline infections, right heart failure or pump thrombosis. To further improve outcome after LVAD implantation, early detection of deterioration is key to enable early treatment. Therefore, the aim of this thesis was to identify LVAD patients at risk and to explore possibilities of remote monitoring possibilities.

For example, we have demonstrated that outcomes after a HeartMate3 LVAD implantation are better compared to HeartWare LVAD implantation. In addition, we showed that patients with a higher BMI, a longer ICU duration and a history of atrial fibrillation prior to implantation are more likely to develop late right ventricular failure. In addition, it was demonstrated that hyperpolypharmacy (the use of more than 10 medications) occurs regularly in this patient group. There are various ways to monitor LVAD patients (remotely) in order to recognize and treat complications at an early stage. We demonstrated that the biomarker sST2 can play an important role for monitoring purposes. We also developed an algorithm to monitor LVAD parameters which helps in the early recognition of certain complications. In this way, outcomes LVAD implantation can be further improved.
ANALISIS KINERJA KEUANGAN PT TELKOM INDONESIA (PERSERO) TBK MELALUI ANALISIS RASIO KEUANGAN TAHUN
Authors: Marsheline A.P  , Sindi S.D Manalu  , Filipus Teguh S  , M.L Denny Tewu
Published: October 2023

Abstrak

Mengukur kinerja keuangan perusahaan adalah hal yang penting yang perlu dilakukan manajemen perusahaan. Buat melaksanakan penilaian fundamental terhadap performa perusahaan serta perancangan tujuan di masa yang akan datang, hal ini berkaitan menggunakan penilaian kinerja keuangan perusahaan dalam suatu periode tertentu. Topik dalam penulisan jurnal ini ialah Analisis Kinerja Keuangan PT Telkom Indonesia (Persero) Tbk sesuai rasio keuangan yaitu rasio likuiditas, rasio profitabilitas, rasio solvabilitas, serta rasio aktivitas tahun 2020 hingga dengan tahun 2022. Teknik pengumpulan data memakai penelitian lapangan melalui website BEI serta website resmi Telkom Indonesia. Penelitian ini memperoleh hasil rasio likuiditas yang memperlihatkan kenaikan sehingga menunjukkan bahwa perusahaan pada kondisi likuid, rasio solvabilitas mengalami penurunan menandakan kalau perusahaan dalam kondisi aman, sedangkan rasio profitabilitas dan rasio aktivitas menunjukkan bahwa perusahaan dalam syarat yang kurang menguntungkan sebab mengalami penurunan sehingga perlu ditingkatkan lagi.

Kata Kunci : Analisis, Kinerja, Laporan, Rasio Keuangan.

 

Abstrak

Mengukur kinerja keuangan perusahaan adalah hal yang penting yang perlu dilakukan manajemen perusahaan. Buat melaksanakan penilaian fundamental terhadap performa perusahaan serta perancangan tujuan di masa yang akan datang, hal ini berkaitan menggunakan penilaian kinerja keuangan perusahaan dalam suatu periode tertentu. Topik dalam penulisan jurnal ini ialah Analisis Kinerja Keuangan PT Telkom Indonesia (Persero) Tbk sesuai rasio keuangan yaitu rasio likuiditas, rasio profitabilitas, rasio solvabilitas, serta rasio aktivitas tahun 2020 hingga dengan tahun 2022. Teknik pengumpulan data memakai penelitian lapangan melalui website BEI serta website resmi Telkom Indonesia. Penelitian ini memperoleh hasil rasio likuiditas yang memperlihatkan kenaikan sehingga menunjukkan bahwa perusahaan pada kondisi likuid, rasio solvabilitas mengalami penurunan menandakan kalau perusahaan dalam kondisi aman, sedangkan rasio profitabilitas dan rasio aktivitas menunjukkan bahwa perusahaan dalam syarat yang kurang menguntungkan sebab mengalami penurunan sehingga perlu ditingkatkan lagi.

Keywords : Analysis, Performance, Reports, Financial Ratios.
The level of emotional intelligence among Saudi nursing students: A cross-sectional study
Authors: Almansour Ahmed Mansour
Published: October 2023

Background: Emotional intelligence is an individual’s capacity to comprehend, use, and control their own emotions to communicate and connect with people successfully. The emotional intelligence level among nursing students indicates their ability to regulate their emotions, possess self-awareness, demonstrate empathy, have motivation, and display social skills, impacting how they adapt during their education and preparation for nursing care. However, studies investigating emotional intelligence in the Saudi Arabian context are scarce.
Objective: This study aimed to evaluate the degree of emotional intelligence and its differences according to sociodemographic variables among nursing students in Saudi Arabia.
Methods: A cross-sectional study was undertaken with 322 nursing students conveniently selected at Majmaah University, Saudi Arabia. Data were collected between May and June 2023 utilizing the Schutte Self-Report Emotional Intelligence Test (SSEIT). Descriptive statistics, such as mean, standard deviation, frequency, and percentage, independent t-test, and one-way ANOVA were used for data analysis.
Results: Most of the students had emotional intelligence levels ranging from moderate to high (96.6%). There were significant differences in emotional intelligence levels according to the age of students, gender, year of study, marital status, mother’s education, physical and psychological health, and grade point average (p <0.05).
Conclusion: The study findings may offer valuable insights for nursing educators in universities, emphasizing the importance of enhancing emotional intelligence and integrating it into nursing curricula. Additionally, it highlights the need to develop effective strategies and training sessions and workshops according to sociodemographic factors to enhance emotional intelligence levels among nursing students.
Relationship between dyslexia awareness and stigma among nursing students in Saudi Arabia: A cross-sectional study
Authors: Hafez Duaa , Shafie Raghad , Alasiri Renad , Bamasag Renad , Batwa Zikra , Mahsoon Alaa , Sharif Loujain , Alasmee Nofaa
Published: October 2023

Background: Dyslexia—a learning disorder characterized by difficulty in word-level reading skills—can negatively impact nursing students’ practice, which can, in turn, affect patient safety. Individuals with dyslexia are often stigmatized. There is a need to explore dyslexia awareness among nursing students and its relationship with stigma in Saudi Arabia.
Objective: This study aimed to assess the dyslexia awareness levels among nursing students and its relation to stigma.
Methods: A quantitative cross-sectional study was conducted on 154 nursing students at King Abdulaziz University, Saudi Arabia. Data were collected by asking the students to virtually complete the Knowledge and Beliefs about Developmental Dyslexia Scale (KBDDS) and the Consciousness Questionnaire-Learning Disabilities (SCQ-LD) from February to March 2021. Data were analyzed using chi-square tests to test significance and Cramer’s V to determine the strength of the relationships among the categorical variables.
Results: The overall dyslexia awareness level was moderate. Most participants believed that people had negative assumptions about individuals with dyslexia and that they judged and treated them differently. A moderately strong positive association was revealed between knowledge of the stigma surrounding dyslexia and knowledge of dyslexia itself (p <0.001).
Conclusions: Increased dyslexia awareness is correlated with greater anticipation that dyslexic individuals will be stigmatized. Therefore, dyslexia awareness should be raised among nursing students. Students or nurses with dyslexia should also be encouraged to learn appropriate coping strategies to ensure patient safety.
Circulating Exosomal miRNAs as a Promising Diagnostic Biomarker in Cancer
Authors: Lohajová Behulová R , Bugalová A , Bugala J , Struhárňanská E , Šafranek M , Juráš I
Published: October 2023

Cancer belongs to multifactorial diseases characterized by uncontrolled growth and proliferation of abnormal cells. Breast cancer, non-small cell lung cancer, and colorectal cancer are the most frequently diagnosed malignancies with a high mortality rate. These carcinomas typically contain multiple genetically distinct subpopulations of tumor cells leading to tumor heterogeneity, which promotes the aggressiveness of the disease. Early diagnosis is necessary to increase patient progression-free survival. Particularly, miRNAs present in exosomes derived from tumors represent potential biomarkers suitable for early cancer diagnosis. Identification of miRNAs by liquid biopsy enables a personalized approach with the subsequent better clinical management of patients. This review article highlights the potential of circulating exosomal miRNAs in early breast, non-small cell lung, and colorectal cancer diagnosis.
Tumor-Infiltrating Lymphocytes and Adoptive Cell Therapy: State of the Art in Colorectal, Breast and Lung Cancer
Authors: ZEMANEK T , NOVA Z , NICODEMOU A
Published: October 2023

Our knowledge of tumor-infiltrating lymphocytes (TILs) is dramatically expanding. These cells have proven prognostic and therapeutic value for many cancer outcomes and potential to treat also disseminated breast, colorectal, or lung cancer. However, the therapeutical outcome of TILs is negatively affected by tumor mutational burden and neoantigens. On the other hand, it can be improved in combination with checkpoint blockade therapy. This knowledge and rapid detection techniques alongside gene editing allow us to classify and modify T cells in many ways. Hence, to tailor them precisely to the patient´s needs as to program T cell receptors to recognize specific tumor-associated neoantigens and to insert them into lymphocytes or to select tumor neoantigen-specific T cells, for the development of vaccines that recognize tumor-specific antigens in tumors or metastases. Further studies and clinical trials in the field are needed for an even better-detailed understanding of TILs interactions and aiming in the fight against multiple cancers.
Improving fifth-grade students’ learning outcomes using the discovery learning model in integrated thematic learning
Authors: Rahdia Rahma Ella , Lena Mai Sri
Published: October 2023

The background of this research because the activities of providing material in schools many students are less active and cause their learning outcomes not to be maximized. This study uses research methods for planning, actions, observations, and reflections, and also by applying the discovery learning model. This study used 28 fifth grade students at SDN 12 Tanah Sirah Padang City as subjects. Data collection techniques through observation, non-test and test. This study produces data that shows an increase of learning activities and learning outcomes of fifth-grade students. From the results obtained, it can be concluded that the application of the discovery learning model increases the level of integrated thematic learning outcomes from students.
Barriers to English Listening Comprehension for Indonesian University Students: Implications for Listening Curriculum Development
Authors: Wahyuningsih Sri , Salsabila Revanda Putri
Published: October 2023

English has been considered an important means of international communication not only for education but also for career advancement. In general, students find it difficult to understand expressions or sentences in English. The same thing occurs when learning listening comprehension for EFL students in Indonesia. Listening is one of the most difficult skills experienced by students in learning English. The research in this paper aims to investigate the barriers to English listening comprehension of university students in Indonesia and their implications for listening curriculum development. Data were garnered through semi-structured interviews with eight Indonesian higher-education students. The results depict that the barriers experienced by students in listening comprehension include a lack of pronunciation understanding and different accents, a lack of English vocabulary, a lack of voice clarity quality, and difficulty in understanding the speed of pronunciation. To improve listening comprehension, students need to practice listening to audio from native speakers repeatedly, English podcasts, speeches, and inspiring videos via YouTube, English songs, and watching movies. The implications for listening curriculum development were discussed in this paper.
Analysis of Scientific Field Suitability and the Goal Achievement of Certified Independent Study Internship and Learning Activity Form for Undergraduate Students of Social Science Education at Universitas Negeri Malang
Authors: Bramantya David Golddra Pamungkas , Wahyuningtyas Neni
Published: October 2023

Form of Learning Activity (BKP) of certified independent study internship (MSIB) is an activity that is intended for students to get to know the current world of work. However, based on its implementation, the achievement of the objectives and suitability of BKP MSIB with the scientific field study programs becomes a real issue in the implementation of BKP MSIB. This paper aims to describe the achievement of the objectives of BKP MSIB for undergraduate students at the Social Science Education Study Program of UM, as well as the suitability of BKP MSIB followed by undergraduate students at the UM Social Science Education with the scientific field study program. The study uses a descriptive narrative study method to answer the formulation of the problem based on the students’ experience of BKP MSIB participants who came from S1 UM Social Science Education. The research results indicate the achievement of the objectives of BKP MSIB. Students get the right fulfillment to obtain experience in the implementation of BKP MSIB. The right fulfillment to obtain experience is evidenced by the experience of getting off the field for 1-4 months (for certified internships), as well as the real-world issues, which are raised to be reviewed in the classroom (for Certified Independent Studies). Based on its implementation on undergraduate students of UM Social Science Education, it turns out that BKP MSIB still has shortcomings. The shortcomings include the incompatibility between BKP MSIB taken by S1 students of UM Social Science Education with the scientific field study program. Furthermore, based on the research, it is still found students who have a sense of “compulsion” to undergo BKP MSIB MBKM.
The Effect of Parents’ Parenting Style on the Fourth-Grade Natural Science Students’ Learning Motivation at Elementary School
Authors: Halawa Harniwati , Lumbanraja Bogor , Silaban Patri Janson , Anzelina Dewi , Sitepu Anton
Published: October 2023

This paper explains the effect of parents’ parenting style on natural science students’ motivation. The research was conducted in class IV at SD Negeri Medan Johor. The researchers used associative quantitative research methods. The population used was 36 fourth-grade students at SD Negeri 060938 Medan Johor. Sampling used total sampling (saturated sampling). The research results indicate that the results obtained from the correlation test can be seen in the correlation coefficient of rcount 0.97 ≥ rtable 0.329, hence it can be concluded that the alternative hypothesis (Ha) is accepted, it means that there is an effect of parents’ parenting style on students’ learning motivation at SD Negeri 060938 Medan Johor. It can also be seen from the t-test results where tcount 25.73 ≥ ttable 2.030, hence the hypothesis (Ha) is accepted. It shows that there is a positive significant effect between the effect of parents’ parenting style and natural science students' learning motivation in class IV at SD Negeri Medan Johor in the academic year 2022/2023.
KINERJA SATUAN POLISI PAMONG PRAJA DALAM PENERTIBAN PEDAGANG KAKI LIMA DI PASAR SIDIKALANG KABUPATEN DAIRI
Authors: Sihite Amos Parlemen Zepanya , Aruan Jhonatan Timoty B.
Published: October 2023

Maraknya pedagang kaki lima liar di Pasar Sidikalang yang berdampak buruk terhadap penyelenggaraan ketertiban umum. Penelitian ini bertujuan menganalisa serta memperoleh gambaran akurat mengenai kinerja, hambatan dan upaya Satuan Polisi Pamong Praja dalam penertiban pedagang kaki lima di Pasar Sidikalang Kabupaten Dairi. Penelitian ini menggunakan metode deskriptif   kualitatif dengan teknik pengumpulan data wawancara, observasi partisipan, dan dokumentasi. Peneliti menggunakan teori kinerja dari Dwiyanto (2002) yang terdiri dari produktivitas, kualitas layanan, responsivitas, responsibilitas, dan akuntabilitas. Hasil penelitian menemukan adanya tiga indikator yang masih     kurang baik yaitu kualitas layanan, responsibilitas, dan responsvitas serta dua indikator yang sudah cukup baik yaitu produktivitas dan akuntabilitas. Hambatan yang ditemui dalam penertiban yang dilakukan yaitu tingkat kepatuhan para pedagang kaki lima yang rendah. Upaya yang dilakukan adalah peningkatan kemampuan komunikasi aparat, dan peningkatan kapasitas sumber daya manusia.

Kata Kunci: Kinerja, Satuan Polisi Pamong Praja, Pedagang Kaki Lima
TREN PENELITIAN KETERTIBAN UMUM (PUBLIC ORDER): SEBUAH PENDEKATAN BIBLIOMETRIK
Authors: Rahmadanita Annisa
Published: October 2023

Ketertiban umum merupakan kondisi di mana masyarakat berjalan dalam suasana yang aman, damai, dan teratur. Namun perkembangan mengenai ketertiban umum belum diketahui secara rinci. Kajian ini bertujuan untuk mengetahui tren penelitian di bidang ketertiban umum. Metode penelitian yang digunakan adalah paradigma kuantitatif dengan pendekatan bibliometrik. Peneliti menggunakan teknik purposive sampling dengan batasan Bahasa yang digunakan adalah Bahasa Inggris. Analisis co-word pada analisis bibliometrik yang digunakan oleh peneliti dalam menganalisis data. Analisis data juga menggunakan aplikasi VOSviewer. Temuan penelitian menunjukkan bahwa publikasi ilmiah dengan subjek “public order” pada pangkalan data Scopus sebanyak 2524 dokumen. Pada rentang tahun 1991-2023 dan dibatasi publikasi dengan Bahasa Inggris, tipe dokumen artikel, kata kunci public order, source type journal, dan subject area social sciences, terdapat sebanyak 103 dokumen. Terlihat bahwa jumlah publikasi mengalami peningkatan yang signifikan pada periode tahun 2015 hingga 2017. Tren paling tinggi dalam jumlah publikasi tercatat terjadi pada tahun 2022, dengan total 14 dokumen yang diterbitkan. Terdapat 2856 kata kunci, 25 di antaranya saling berhubungan dan dikelompokkan dalam 4 kluster. Kesimpulannya bahwa terdapat 25 kata kunci yang menjadi tren berdasarkan nilai occurance minimal 10 diantaranya adalah policing, police, freedom, right, event, paper, case, principle, violence, disorder, public space, use, role, international law, person, trend, concept question, threat, Russian federation, citizen, constitution, individual, human right. Kata kunci tersebut menjadi tren disebabkan beberapa faktor yaituadanya konteks sosial dan politik, kasus hukum dan peradilan, perkembangan teknologi dan informasi serta hak asasi manusia dan kebebasan. Topik-topik penelitian terkait dengan konteks sosial dan politik, kasus hukum dan peradilan, perkembangan teknologi dan informasi serta hak asasi manusia dan kebebasan, direkomendasikan untuk penelitian selanjutnya. Perlu dilakukan kajian mendalam dan berkelanjutan terkait topik-topik yang menjadi tren tersebut. Adapun topik "russian federation”, "citizen," "constitution," "individual," dan "human right" memiliki potensi untuk dieksplorasi dalam penelitian mendatang.Kata Kunci: Analisis Kata Kunci, Bibliometrik, Ketertiban Umum, Scopus.
An Unusual Presentation of Penile Kaposi’s Sarcoma in an HIV-Negative Patient with a Circumcised Penis
Authors: Iplikci Ayberk , Keles Ahmet , Somun Umit Furkan , Yilmazer Fatma , Kir Gozde , Yildirim Asif
Published: October 2023

Kaposi sarcoma (KS) is a multifocal hemorrhagic sarcoma that occurs mainly in the extremities. KS limited to the penis is rare and usually associated with acquired immunodeficiency syndrome (AIDS). The clinical presentations and courses of KS in the penis demonstrate variability, with limited reports of non-HIV-related primary KS. Herein, we present the case of a 27-year-old male patient with a classic form of KS who had a primary glans penile macular lesion. In more detailed evaluations, we found no evidence of immunosuppression or systemic involvement of the disease. There was no recurrence in the patient who underwent surgical excision, and he was followed up.
The Effects of Viburnum Opulus L. on Kidneys of Rats with Ethylene Glycol-induced Nephrolithiasis
Authors: Şam Emre , Ekşi Mithat , Akkaş Fatih , Baytekin Halil Fırat , Güler Eray Metin , Şimşek Abdulmuttalip , Atar Feyzi Arda , Koçyiğit Abdurrahim , Taşçı Ali İhsan
Published: October 2023

Objective: Recent research has centered on the role of oxidative stress and free oxygen radicals in the formation of stones. Viburnum opulus L. (VO) is a fruit species known for its antioxidant activity, and its juice preparation is used in Turkish traditional medicine for stone removal. This study aimed to investigate the effects of VO on calcium oxalate (CaOx) crystallization and oxidative stress in rats with ethylene glycol (EG)-induced nephrolithiasis. Material and Methods: Fifty adult male Wistar Hannover rats were divided into five groups: control (Group 1), EG (Group 2), EG + 50 mg/kg VO (Group 3), EG + 100 mg/kg VO (Group 4), and EG + 200 mg/kg VO (Group 5). On days 7, 14, and 28, 24-hour urine was collected, and blood samples were taken. On day 28, the rats were sacrificed, and inflammation, oxidative stress, and CaOx crystallization in kidney tissue were evaluated under polarized light microscopy. Results: A statistically significant difference was found between Group 1 and Group 2 in terms of serum inflammation parameters, acute kidney injury, and oxidative stress evaluated on days 7, 14, and 28, and tissue inflammation and oxidative stress parameters evaluated on day 28. It was observed that these parameters improved in Groups 3-5 compared to Group 2, and the level of statistical significance increased as the dose increased. In the histopathological evaluation of the tissues on day 28, the mean number of crystals was statistically significantly higher in Group 2 than in Group 1. These parameters improved in Groups 3-5 compared to Group 2, and there was a statistically significant difference when Groups 4 and 5 were compared to Group 2. Conclusion: It was found that VO improved inflammation, oxidative stress, acute kidney injury, and CaOx crystallization in rats with EG-induced nephrolithiasis in direct proportion to the increase in dose.
Hemodialysis Vascular Access and Care
Authors: Kavurmacı Mehtap
Published: October 2023

Hemodialysis remains the most widely used method for treating renal failure. Life expectancy and quality in hemodialysis are directly proportional to the quality of dialysis, and this quality depends on the reliability and integrity of the patient’s vascular access route. The ideal vascular access route provides reliable, uncomplicated access to dialysis and is also suitable for the patient’s needs. Hemodialysis vascular access options have not changed substantially over the past six decades, and arteriovenous fistula (AVF) remains the access of choice. Although AVF is a vascular intervention recommended and preferred in clinical practice guidelines for hemodialysis, it can develop into serious complications such as thrombosis, hematoma, edema, peripheral ischemia, bleeding, and infection. To prevent these complications, it is extremely important to educate patients about AVF care. This review has been prepared as a guide for healthcare professionals who care for hemodialysis patients.
The Biological Origins of Gender, not Sex: A Review of Psychobiological Evidence - Evolution and the Reproductive Axis
Authors: Woodhill Bobbi , Samuels Curtis , Jamieson Graham
Published: October 2023

In brief We present our understanding of a biological component of gender in the evolutionary canalized reproductive axis. We combine our findings into a model that accounts for a core component of gender identity distinct from bodily sex, sexual orientation, or sex (gender) roles.
Living myocardial slices for the study of nucleic acid-based therapies
Authors: Nunez-Toldra R. , Del Canizo A. , Secco I. , Nicastro L. , Giacca M. , Terracciano C. M.
Published: October 2023

Gene therapy based on viral vectors offers great potential for the study and the treatment of cardiac diseases. Here we explore the use of Living Myocardial Slices (LMS) as a platform for nucleic acid-based therapies. Rat LMS and Adeno-Associated viruses (AAV) were used to optimise and analyse gene transfer efficiency, viability, tissue functionality, and cell tropism in cardiac tissue. Human cardiac tissue from failing (dilated cardiomyopathy) hearts was also used to validate the model in a more translational setting. LMS were cultured at physiological sarcomere length for 72-h under electrical stimulation. Two recombinant AAV serotypes (AAV6 and AAV9) at different multiplicity of infection (MOI) expressing enhanced green fluorescent protein (eGFP) were added to the surface of rat LMS. AAV6 at 20,000 MOI proved to be the most suitable serotype without affecting LMS contractility or kinetics and showing high transduction and penetrability efficiency in rat LMS. This serotype exhibited 40% of transduction efficiency in cardiomyocytes and stromal cells while 20% of the endothelial cells were transduced. With great translational relevance, this protocol introduces the use of LMS as a model for nucleic acid-based therapies, allowing the acceleration of preclinical studies for cardiac diseases.
Endothelial cell dysfunction in cardiac disease: driver or consequence?
Authors: Allbritton-King Jules D. , García-Cardeña Guillermo
Published: October 2023

The vascular endothelium is a multifunctional cellular system which directly influences blood components and cells within the vessel wall in a given tissue. Importantly, this cellular interface undergoes critical phenotypic changes in response to various biochemical and hemodynamic stimuli, driving several developmental and pathophysiological processes. Multiple studies have indicated a central role of the endothelium in the initiation, progression, and clinical outcomes of cardiac disease. In this review we synthesize the current understanding of endothelial function and dysfunction as mediators of the cardiomyocyte phenotype in the setting of distinct cardiac pathologies; outline existing in vivo and in vitro models where key features of endothelial cell dysfunction can be recapitulated; and discuss future directions for development of endothelium-targeted therapeutics for cardiac diseases with limited existing treatment options.
STING in tumors: a focus on non-innate immune pathways
Authors: Yang Jiaying , Yang Mei , Wang Yingtong , Sun Jicheng , Liu Yiran , Zhang Ling , Guo Baofeng
Published: October 2023

Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating innate immunity by promoting the release of interferon and other inflammatory factors. Mitochondrial DNA (mtDNA) with a double-stranded structure has greater efficiency and sensitivity in being detected by DNA sensors and thus has an important role in the activation of the cGAS-STING pathway. Many previous findings suggest that the cGAS-STING pathway-mediated innate immune regulation is the most important aspect affecting tumor survival, not only in its anti-tumor role but also in shaping the immunosuppressive tumor microenvironment (TME) through a variety of pathways. However, recent studies have shown that STING regulation of non-immune pathways is equally profound and also involved in tumor cell progression. In this paper, we will focus on the non-innate immune system pathways, in which the cGAS-STING pathway also plays an important role in cancer.
First-principles study of Li-doped planar g-C3N5 as reversible H2 storage material
Authors: Chen Xihao , Liu Zonghang , Cheng Jiang , Li Jiwen , Guo Donglin , Zhang Liang , Niu Xianghong , Wang Ning , Wang Guangzhao , Gao Peng
Published: October 2023

Under the background of energy crisis, hydrogen owns the advantage of high combustion and shows considerable environment friendliness; however, to fully utilize this novel resource, the major hurdle lies in its delivery and storage. The development of the in-depth yet systematical methodology for two-dimensional (2D) storage media evaluation still remains to be challenging for computational scientists. In this study, we tried our proposed evaluation protocol on a 2D material, g-C3N5, and its hydrogen storage performance was characterized; and with addition of Li atoms, the changes of its electronical and structural properties were detected. First-principles simulations were conducted to verify its thermodynamics stability; and, its hydrogen adsorption capacity was investigated qualitatively. We found that the charges of the added Li atoms were transferred to the adjacent nitrogen atoms from g-C3N5, with the formation of chemical interactions. Thus, the isolated metallic sites tend to show considerable electropositivity, and can easily polarize the adsorbed hydrogen molecules, and the electrostatic interactions can be enhanced correspondingly. The maximum storage capacity of each primitive cell can be as high as 20 hydrogen molecules with a gravimetric capacity of 8.65 wt%, which surpasses the 5.5 wt% target set by the U.S. Department of Energy. The average adsorption energy is ranged from −0.22 to −0.13 eV. We conclude that the complex 2D material, Li-decorated g-C3N5(Li@C3N5), can serve as a promising media for hydrogen storage. This methodology provided in this study is fundamental yet instructive for future 2D hydrogen storage materials development.
Role of Tau protein in long COVID and potential therapeutic targets
Authors: Marwaha Bharat
Published: October 2023

Introduction

Long COVID is an emerging public health burden and has been defined as a syndrome with common symptoms of fatigue, shortness of breath, cognitive dysfunction, and others impacting day-to-day life, fluctuating or relapsing over, occurring for at least two months in patients with a history of probable or confirmed SARS CoV-2 infection; usually three months from the onset of illness and cannot be explained by an alternate diagnosis. The actual prevalence of long-term COVID-19 is unknown, but it is believed that more than 17 million patients in Europe may have suffered from it during pandemic.

Pathophysiology

Currently, there is limited understanding of the pathophysiology of this syndrome, and multiple hypotheses have been proposed. Our literature review has shown studies reporting tau deposits in tissue samples of the brain from autopsies of COVID-19 patients compared to the control group, and the in-vitro human brain organoid model has shown aberrant phosphorylation of tau protein in response to SARS-CoV-2 infection. Tauopathies, a group of neurodegenerative disorders with the salient features of tau deposits, can manifest different symptoms based on the anatomical region of brain involvement and have been shown to affect the peripheral nervous system as well and explained even in rat model studies. Long COVID has more than 203 symptoms, with predominant symptoms of fatigue, dyspnea, and cognitive dysfunction, which tauopathy-induced CNS and peripheral nervous system dysfunction can explain. There have been no studies up till now to reveal the pathophysiology of long COVID. Based on our literature review, aberrant tau phosphorylation is a promising hypothesis that can be explored in future studies. Therapeutic approaches for tauopathies have multidimensional aspects, including targeting post-translational modifications, tau aggregation, and tau clearance through the autophagy process with the help of lysosomes, which can be potential targets for developing therapeutic interventions for the long COVID. In addition, future studies can attempt to find the tau proteins in CSF and use those as biomarkers for the long COVID.
Knowledge mapping of the relationship between norepinephrine and memory: a bibliometric analysis
Authors: Song Qi , Tan Yaqian
Published: October 2023

Introduction

Memory is a fundamental cognitive function for successful interactions with a complex environment. Norepinephrine (NE) is an essential component of catecholamine induced by emotional arousal, and numerous studies have demonstrated that NE is a key regulator in memory enhancement. We therefore conducted a bibliometric analysis to represent the knowledge pattern of the literature on the theme of NE-memory relationship.

Methods

The WOSCC database was selected to extract literature published during 2003-2022. The collected data of annual production, global cooperation, research structure and hotspots were analyzed and visualized.

Results

Our results showed that research on the links between NE and memory displayed a considerable development trend over the last two decades. The USA had a leading position in terms of scientific outputs and collaborations. Meanwhile, University of California Irvine contributed the most publications. Benno Roozendaal and James McGaugh were the most prolific authors in this field, and Neurobiology of Learning and Memory had the highest number of publications on this topic. The research emphasis has evolved from memory-related diseases and brain regions to neural mechanisms for different types of memory at neural circuit levels.

Conclusion

Our bibliometric analysis systematically analyzed the literature on the links between NE and memory from a bibliometric perspective. The demonstrated results of the knowledge mapping would provide valuable insights into the global research landscape.