bluuebunny/crossref_metadata_2025 huggingface dataset:
Integration of Convolutional Neural Network and Error Correction for Indoor Positioning
Authors: Lu Eric Hsueh-Chan , Ciou Jing-Mei
Published: January 2020

With the rapid development of surveying and spatial information technologies, more and more attention has been given to positioning. In outdoor environments, people can easily obtain positioning services through global navigation satellite systems (GNSS). In indoor environments, the GNSS signal is often lost, while other positioning problems, such as dead reckoning and wireless signals, will face accumulated errors and signal interference. Therefore, this research uses images to realize a positioning service. The main concept of this work is to establish a model for an indoor field image and its coordinate information and to judge its position by image eigenvalue matching. Based on the architecture of PoseNet, the image is input into a 23-layer convolutional neural network according to various sizes to train end-to-end location identification tasks, and the three-dimensional position vector of the camera is regressed. The experimental data are taken from the underground parking lot and the Palace Museum. The preliminary experimental results show that this new method designed by us can effectively improve the accuracy of indoor positioning by about 20% to 30%. In addition, this paper also discusses other architectures, field sizes, camera parameters, and error corrections for this neural network system. The preliminary experimental results show that the angle error correction method designed by us can effectively improve positioning by about 20%.
Changes in the Surface Expression of Intercellular Adhesion Molecule 3, the Induction of Apoptosis, and the Inhibition of Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4 Cells Exposed to a Random Positioning Machine
Authors: Sokolovskaya Alisa , Korneeva Ekaterina , Zaichenko Danila , Virus Edward , Kolesov Dmitry , Moskovtsev Aleksey , Kubatiev Aslan
Published: January 2020

Experiments from flight- and ground-based model systems suggest that unexpected alterations of the human lymphoblastoid cell line Jurkat, as well as effects on cell growth, metabolism, and apoptosis, can occur in altered gravity conditions. Using a desktop random positioning machine (RPM), we investigated the effects of simulated microgravity on Jurkat cells and their multidrug-resistant subline, Jurkat/A4 cells. The viability of Jurkat/A4 cells decreased after simulated microgravity in contrast with the Jurkat cells. At the same time, the viability between the experimental Jurkat cells and control Jurkat cells was not significantly different. Of note, Jurkat cells appeared as less susceptible to apoptosis than their multidrug-resistant clone Jurkat/A4 cells, whereas cell-cycle analysis showed that the percentage of Jurkat/A4 cells in the S-phase was increased after 72 and 96 h of RPM-simulated microgravity relative to their static counterparts. The differences in Jurkat cells at all phases between static and simulated microgravity were not significant. The surface expression of the intercellular adhesion molecule 3 (ICAM-3)—also known as cluster of differentiation (CD)50—protein was changed for Jurkat/A4 cells following exposure to the RPM. Changes in cell morphology were observed in the Jurkat/A4 cells after 96 h of RPM-simulated microgravity. Thus, we concluded that Jurkat/A4 cells are more sensitive to RPM-simulated microgravity as compared with the parental Jurkat cell line. We also suggest that intercellular adhesion molecule 3 may be an important adhesion molecule involved in the induction of leukocyte apoptosis. The Jurkat/A4 cells with an acquired multidrug resistance phenotype could be a useful model for studying the effects of simulated microgravity and testing anticancer drugs.
Influence of Germline Genetics on Tacrolimus Pharmacokinetics and Pharmacodynamics in Allogeneic Hematopoietic Stem Cell Transplant Patients
Authors: Zhu Jing , Patel Tejendra , Miller Jordan A. , Torrice Chad D. , Aggarwal Mehak , Sketch Margaret R. , Alexander Maurice D. , Armistead Paul M. , Coghill James M. , Grgic Tatjana , Jamieson Katarzyna J. , Ptachcinski Jonathan R. , Riches Marcie L. , Serody Jonathan S. , Schmitz John L. , Shaw J. Ryan , Shea Thomas C. , Suzuki Oscar , Vincent Benjamin G. , Wood William A. , Rao Kamakshi V. , Wiltshire Tim , Weimer Eric T. , Crona Daniel J.
Published: January 2020

Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well as a narrow therapeutic index, and therefore requires therapeutic drug monitoring. Germline mutations in cytochrome P450 isoforms 4 and 5 genes (CYP3A4/5) and the ATP-binding cassette B1 gene (ABCB1) may contribute to interindividual tacrolimus PK variability, which may impact clinical outcomes among allogeneic hematopoietic stem cell transplantation (HSCT) patients. In this study, 252 adult patients who received tacrolimus for acute graft versus host disease (aGVHD) prophylaxis after allogeneic HSCT were genotyped to evaluate if germline genetic variants associated with tacrolimus PK and pharmacodynamic (PD) variability. Significant associations were detected between germline variants in CYP3A4/5 and ABCB1 and PK endpoints (e.g., median steady-state tacrolimus concentrations and time to goal tacrolimus concentration). However, significant associations were not observed between CYP3A4/5 or ABCB1 germline variants and PD endpoints (e.g., aGVHD and treatment-emergent nephrotoxicity). Decreased age and CYP3A5*1/*1 genotype were independently associated with subtherapeutic tacrolimus trough concentrations while CYP3A5*1*3 or CYP3A5*3/*3 genotypes, myeloablative allogeneic HSCT conditioning regimen (MAC) and increased weight were independently associated with supratherapeutic tacrolimus trough concentrations. Future lines of prospective research inquiry are warranted to use both germline genetic and clinical data to develop precision dosing tools that will optimize both tacrolimus dosing and clinical outcomes among adult HSCT patients.
The Peroxisomal PTS1-Import Defect of PEX1- Deficient Cells Is Independent of Pexophagy in Saccharomyces cerevisiae
Authors: Mastalski Thomas , Brinkmeier Rebecca , Platta Harald W.
Published: January 2020

The important physiologic role of peroxisomes is shown by the occurrence of peroxisomal biogenesis disorders (PBDs) in humans. This spectrum of autosomal recessive metabolic disorders is characterized by defective peroxisome assembly and impaired peroxisomal functions. PBDs are caused by mutations in the peroxisomal biogenesis factors, which are required for the correct compartmentalization of peroxisomal matrix enzymes. Recent work from patient cells that contain the Pex1(G843D) point mutant suggested that the inhibition of the lysosome, and therefore the block of pexophagy, was beneficial for peroxisomal function. The resulting working model proposed that Pex1 may not be essential for matrix protein import at all, but rather for the prevention of pexophagy. Thus, the observed matrix protein import defect would not be caused by a lack of Pex1 activity, but rather by enhanced removal of peroxisomal membranes via pexophagy. In the present study, we can show that the specific block of PEX1 deletion-induced pexophagy does not restore peroxisomal matrix protein import or the peroxisomal function in beta-oxidation in yeast. Therefore, we conclude that Pex1 is directly and essentially involved in peroxisomal matrix protein import, and that the PEX1 deletion-induced pexophagy is not responsible for the defect in peroxisomal function. In order to point out the conserved mechanism, we discuss our findings in the context of the working models of peroxisomal biogenesis and pexophagy in yeasts and mammals.
Cationic Polymer Nanoparticles-Mediated Delivery of miR-124 Impairs Tumorigenicity of Prostate Cancer Cells
Authors: Conte Raffaele , Valentino Anna , Di Cristo Francesca , Peluso Gianfranco , Cerruti Pierfrancesco , Di Salle Anna , Calarco Anna
Published: January 2020

MicroRNAs (miRNAs) play a pivotal role in regulating the expression of genes involved in tumor development, invasion, and metastasis. In particular, microRNA-124 (miR-124) modulates the expression of carnitine palmitoyltransferase 1A (CPT1A) at the post-transcriptional level, impairing the ability of androgen-independent prostate cancer (PC3) cells to completely metabolize lipid substrates. However, the clinical translation of miRNAs requires the development of effective and safe delivery systems able to protect nucleic acids from degradation. Herein, biodegradable polyethyleneimine-functionalized polyhydroxybutyrate nanoparticles (PHB-PEI NPs) were prepared by aminolysis and used as cationic non-viral vectors to complex and deliver miR-124 in PC3 cells. Notably, the PHB-PEI NPs/miRNA complex effectively protected miR-124 from RNAse degradation, resulting in a 30% increase in delivery efficiency in PC3 cells compared to a commercial transfection agent (Lipofectamine RNAiMAX). Furthermore, the NPs-delivered miR-124 successfully impaired hallmarks of tumorigenicity, such as cell proliferation, motility, and colony formation, through CPT1A modulation. These results demonstrate that the use of PHB-PEI NPs represents a suitable and convenient strategy to develop novel nanomaterials with excellent biocompatibility and high transfection efficiency for cancer therapy.
Interplay between BRCA1 and GADD45A and Its Potential for Nucleotide Excision Repair in Breast Cancer Pathogenesis
Authors: Pietrasik Sylwia , Zajac Gabriela , Morawiec Jan , Soszynski Miroslaw , Fila Michal , Blasiak Janusz
Published: January 2020

A fraction of breast cancer cases are associated with mutations in the BRCA1 (BRCA1 DNA repair associated, breast cancer type 1 susceptibility protein) gene, whose mutated product may disrupt the repair of DNA double-strand breaks as BRCA1 is directly involved in the homologous recombination repair of such DNA damage. However, BRCA1 can stimulate nucleotide excision repair (NER), the most versatile system of DNA repair processing a broad spectrum of substrates and playing an important role in the maintenance of genome stability. NER removes carcinogenic adducts of diol-epoxy derivatives of benzo[α]pyrene that may play a role in breast cancer pathogenesis as their accumulation is observed in breast cancer patients. NER deficiency was postulated to be intrinsic in stage I of sporadic breast cancer. BRCA1 also interacts with GADD45A (growth arrest and DNA damage-inducible protein GADD45 alpha) that may target NER machinery to actively demethylate genome sites in order to change the expression of genes that may be important in breast cancer. Therefore, the interaction between BRCA1 and GADD45 may play a role in breast cancer pathogenesis through the stimulation of NER, increasing the genomic stability, removing carcinogenic adducts, and the local active demethylation of genes important for cancer transformation.
The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma
Authors: Jeong Youn Kyoung , Oh Ju Yeon , Yoo Jae Kuk , Lim Sun Ha , Kim Eun Ho
Published: January 2020

The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or cell cycle arrest. However, whether medina also facilitates treatment of hepatocellular carcinoma (HCC), the third global cause of cancer deaths, remains unknown. Here, we examined its potential as a radiosensitizer in HCC radiotherapy using human HCC Hep3B and HepG2 cell lines and xenograft tumors. Mesima pretreatment significantly enhanced HCC cell radiosensitivity in vitro and the combination of mesima + radiation treatment significantly reduced xenograft tumor growth and size in vivo compared to those with single treatments. Mechanistically, mesima significantly enhanced radiotherapy efficiency by inhibiting tumor cell survival through inducing apoptosis (assessed via annexin V), impairing cell cycle regulation (shown by flow cytometry), and reducing radiation-induced DNA damage repair (measured via γ-H2AX foci). Combination treatment also facilitated autophagic cell death beyond that from single treatments (assessed by quantifying stained acidic vesicular organelles), and diminished tumor cell metastatic potentials (shown by wound and Transwell assays). These findings support the synergistic anti-tumor effects of mesima combined with radiation and suggest scientific evidence for mesima as a radiosensitizer in HCC.
The miRNAs Role in Melanoma and in Its Resistance to Therapy
Authors: Varrone Francesca , Caputo Emilia
Published: January 2020

Melanoma is the less common but the most malignant skin cancer. Since the survival rate of melanoma metastasis is about 10–15%, many different studies have been carried out in order to find a more effective treatment. Although the development of target-based therapies and immunotherapeutic strategies has improved chances for patient survival, melanoma treatment still remains a big challenge for oncologists. Here, we collect recent data about the emerging role of melanoma-associated microRNAs (miRNAs) currently available treatments, and their involvement in drug resistance. We also reviewed miRNAs as prognostic factors, because of their chemical stability and resistance to RNase activity, in melanoma progression. Moreover, despite miRNAs being considered small conserved regulators with the limitation of target specificity, we outline the dual role of melanoma-associated miRNAs, as oncogenic and/or tumor suppressive factors, compared to other tumors.
The Role of Immune Checkpoint Blockade in Uveal Melanoma
Authors: Wessely Anja , Steeb Theresa , Erdmann Michael , Heinzerling Lucie , Vera Julio , Schlaak Max , Berking Carola , Heppt Markus Vincent
Published: January 2020

Uveal melanoma (UM) represents the most common intraocular malignancy in adults and accounts for about 5% of all melanomas. Primary disease can be effectively controlled by several local therapy options, but UM has a high potential for metastatic spread, especially to the liver. Despite its clinical and genetic heterogeneity, therapy of metastatic UM has largely been adopted from cutaneous melanoma (CM) with discouraging results until now. The introduction of antibodies targeting CTLA-4 and PD-1 for immune checkpoint blockade (ICB) has revolutionized the field of cancer therapy and has achieved pioneering results in metastatic CM. Thus, expectations were high that patients with metastatic UM would also benefit from these new therapy options. This review provides a comprehensive and up-to-date overview on the role of ICB in UM. We give a summary of UM biology, its clinical features, and how it differs from CM. The results of several studies that have been investigating ICB in metastatic UM are presented. We discuss possible reasons for the lack of efficacy of ICB in UM compared to CM, highlight the pitfalls of ICB in this cancer entity, and explain why other immune-modulating therapies could still be an option for future UM therapies.
The Influence of Test-Panel Orientation and Exposure Angle on the Corrosion Rate of Carbon Steel. Mathematical Modelling
Authors: Santana Juan J. , Cano Víctor , Vasconcelos Helena C. , Souto Ricardo M.
Published: January 2020

The effects of both test-panel orientation and exposure angle on the atmospheric corrosion rates of carbon steel probes exposed to a marine atmosphere were investigated. Test samples were exposed in a tree-shape metallic frame with either three exposure angles of 30°, 45° and 60° and orientation north-northeast (N-NE), or eight different orientation angles around a circumference. It was found that the experimental corrosion rates of carbon steel decreased for the specimens exposed with greater exposure angles, whereas the highest corrosion rates were found for those oriented to N-NE due to the influence of the prevailing winds. The obtained data obtained were fitted using the bi-logarithmic law and its variations as to take in account the amounts of pollutants and the time of wetness (TOW) for each particular case with somewhat good agreement, although these models failed when all the effects were considered simultaneously. In this work, we propose a new mathematical model including qualitative variables to account for the effects of both exposure and orientation angles while producing the highest quality fits. The goodness of the fit was used to determine the performance of the mathematical models.
Uptake of Inorganic and Organic Nitrogen Sources by Dinophysis acuminata and D. acuta
Authors: García-Portela María , Reguera Beatriz , Gago Jesús , Le Gac Mickael , Rodríguez Francisco
Published: January 2020

Dinoflagellate species of Dinophysis are obligate mixotrophs that require light, nutrients, and prey for sustained growth. Information about their nitrogenous nutrient preferences and their uptake kinetics are scarce. This study aimed to determine the preferred nitrogen sources in cultures of D. acuminata and D. acuta strains from the Galician Rías Baixas (NW Spain) and to compare their uptake kinetics. Well-fed versus starved cultures of D. acuminata and D. acuta were supplied with N15 labeled inorganic (nitrate, ammonium) and organic (urea) nutrients. Both species showed a preference for ammonium and urea whereas uptake of nitrate was negligible. Uptake rates by well-fed cells of D. acuminata and D. acuta were 200% and 50% higher, respectively, than by starved cells. Uptake of urea by D. acuminata was significantly higher than that of ammonium in both nutritional conditions. In contrast, similar uptake rates of both compounds were observed in D. acuta. The apparent inability of Dinophysis to take up nitrate suggests the existence of incomplete nitrate-reducing and assimilatory pathways, in line with the paucity of nitrate transporter homologs in the D. acuminata reference transcriptome. Results derived from this study will contribute to understand Harmful Algal Blooms succession and differences in the spatio-temporal distribution of the two Dinophysis species when they co-occur in stratified scenarios.
Saliva Samples as A Tool to Study the Effect of Meal Timing on Metabolic And Inflammatory Biomarkers
Authors: Kessler Katharina , Hornemann Silke , Rudovich Natalia , Weber Daniela , Grune Tilman , Kramer Achim , Pfeiffer Andreas F. H. , Pivovarova-Ramich Olga
Published: January 2020

Meal timing affects metabolic regulation in humans. Most studies use blood samples for their investigations. Saliva, although easily available and non-invasive, seems to be rarely used for chrononutritional studies. In this pilot study, we tested if saliva samples could be used to study the effect of timing of carbohydrate and fat intake on metabolic rhythms. In this cross-over trial, 29 nonobese men were randomized to two isocaloric 4-week diets: (1) carbohydrate-rich meals until 13:30 and high-fat meals between 16:30 and 22:00 or (2) the inverse order of meals. Stimulated saliva samples were collected every 4 h for 24 h at the end of each intervention, and levels of hormones and inflammatory biomarkers were assessed in saliva and blood. Cortisol, melatonin, resistin, adiponectin, interleukin-6 and MCP-1 demonstrated distinct diurnal variations, mirroring daytime reports in blood and showing significant correlations with blood levels. The rhythm patterns were similar for both diets, indicating that timing of carbohydrate and fat intake has a minimal effect on metabolic and inflammatory biomarkers in saliva. Our study revealed that saliva is a promising tool for the non-invasive assessment of metabolic rhythms in chrononutritional studies, but standardisation of sample collection is needed in out-of-lab studies.
Promoting Evidence Based Nutrition Education Across the World in a Competitive Space: Delivering a Massive Open Online Course
Authors: Gibson Simone , Adamski Melissa , Blumfield Michelle , Dart Janeane , Murgia Chiara , Volders Evelyn , Truby Helen
Published: January 2020

The internet is the fastest growing source of nutrition information for consumers. Massive Open Online Courses (MOOCs) provide and avenue for nutrition professionals’ urgent need to respond to consumer demand for low-cost, accessible and engaging information. This research aimed to evaluate learner participation and perceptions in an evidence-based nutrition MOOC and provide recommendations for engaging international online lay audiences. Learners completed pre and post course surveys including quantitative and open-ended questions. Pre-course surveys collected demographic data, prior nutrition knowledge and motivations for doing the course. Post-course surveys evaluated their preferred learning modes and learners’ opinions of the course. Quantitative were analyzed using descriptive statistics. Conventional content analysis was conducted on learners’ responses to open-ended survey questions using an inductive approach. Learners represented 158 countries from a range of educational backgrounds. There were 3799 qualitative comments related to learners’ learning and course content preferences. Qualitative analysis identified key themes related to (1) online interaction, the (2) value of the evidence presented by nutrition experts and (3) the course structure and practical aspects. Divergent opinions were expressed within these themes. Satisfying the needs of large international audiences with diverse backgrounds is challenging in promoting sound evidence-based nutrition messages. MOOCs provide a means for delivering evidence based global nutrition education in the online space crowded with food advertising and nutrition conjecture. Recommendations are made as to how to construct and engage diverse on-line audiences.
Total Sugar Intake and Macro and Micronutrients in Children Aged 6–8 Years: The ANIVA Study
Authors: Morales-Suarez-Varela María , Peraita-Costa Isabel , Llopis-Morales Agustín , Picó Yolanda , Bes-Rastrollo Maira , Llopis-Gonzalez Agustín
Published: January 2020

The objective of this study was to study the association between total sugar intake (TSI) levels of children aged 6–8 years old, nutrient intake and anthropometry. Food and beverage intakes were collected by a prospective three-day recall questionnaire. The 2237 children were distributed into three groups according to TSI percentiles. Mean TSI was 93.77 ± 25.72 g/day, 22%–25% of total caloric intake, with boys presenting an intake of 96.24 ± 24.34 g/day and girls 91.38 ± 26.78 g/day. Greater TSI was associated with higher body fat, parental education, energy intake, nutrients/1000 kcal, and lower weight z-scores, BMI z-scores, waist circumferences, and hip circumferences. Weight, height, and waist circumference had the highest R2 while body fat had the lowest. The percentage of total energy derived (%E) from protein decreased as the %E from TSI increased, while the opposite was true for carbohydrates and saccharides, while for fiber intake, the medium groups presented the highest intake/1000 kcal. For the remaining macronutrients studied, intake/1000 kcal decreased when the %E from TSI increased. Calcium, iodine, magnesium, vitamin B2, folate, and vitamin C intake increased as the %E from TSI increased, while the opposite was true for vitamin B12. Fiber, ω-6 PUFA, iodine, folate, vitamin D, and vitamin E intakes were insufficient across most of the sample. TSI levels in children were identified to exceed adult recommendations. It is not clear what the effect of up to an average of 21% of energy coming from total sugars has on childhood obesity and further research is needed in the pediatric population, however, opportunities exist to improve sugar intake patterns.
Combined Soluble Fiber-Mediated Intestinal Microbiota Improve Insulin Sensitivity of Obese Mice
Authors: Xu Chuanhui , Liu Jianhua , Gao Jianwei , Wu Xiaoyu , Cui Chenbin , Wei Hongkui , Zheng Rong , Peng Jian
Published: January 2020

Dietary fiber, an important regulator of intestinal microbiota, is a promising tool for preventing obesity and related metabolic disorders. However, the functional links between dietary fiber, intestinal microbiota, and obesity phenotype are still not fully understood. Combined soluble fiber (CSF) is a synthetic mixture of polysaccharides and displays high viscosity, water-binding capacity, swelling capacity, and fermentability. We found that supplementing high-fat diet (HFD) with 6% CSF significantly improved the insulin sensitivity of obese mice without affecting their body weight. Replacing the HFD with normal chow basal diet (NCD), the presence of CSF in the feed significantly enhanced satiety, decreased energy intake, promoted weight and fat loss, and augmented insulin sensitivity. CSF also improved the intestinal morphological integrity, attenuated systemic inflammation, promoted intestinal microbiota homeostasis, and stabilized the production of short-chain fatty acids (SCFAs) that was perturbed during HFD-induced obesity, and these stabilizing effects were more prominent when the basal diet was switched to NCD. The enrichment of bacteria of the S24-7 family and Allobaculum genus increased markedly in the intestine following 6% CSF supplementation- and correlated with decreased adiposity and insulin resistance. Five bacterial genera that were decreased by CSF, including Oscillospira, unclassified Lachonospitaceae, unclassified Clostridiales, unclassified Desulfovibrionaceae, and unclassified Ruminococcae, were subjected to co-occurrence network analysis and were positively correlated to adiposity and insulin resistance, indicating a key role in the microbial response to CSF. Thus, CSF has a potential to promote insulin sensitivity and even reduce obesity via beneficial regulation of the gut microecosystem.
Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex
Authors: Sbrini Giulia , Brivio Paola , Fumagalli Marco , Giavarini Flavio , Caruso Donatella , Racagni Giorgio , Dell’Agli Mario , Sangiovanni Enrico , Calabrese Francesca
Published: January 2020

A wide range of people in the world use natural remedies as primary approaches against illnesses. Accordingly, understanding the mechanisms of action of phytochemicals has become of great interest. In this context, Centella asiatica L. is extensively used, not only as anti-inflammatory or antioxidant agent but also as brain tonic. On this basis, the purpose of this study was to evaluate whether the chronic administration of C. asiatica L. to adult male rats was able to improve the expression of Bdnf, one of the main mediators of brain plasticity. Moreover, we assessed whether the treatment could affect the cognitive performance in the novel object recognition (NOR) test. We confirmed the presence of the main compounds in the plasma. Furthermore, C. asiatica L. administration induced an increase of Bdnf in the prefrontal cortex, and the administration of the higher dose of the extract was able to improve cognitive performance. Finally, the increase in the preference index in the NOR test was paralleled by a further increase in Bdnf expression. Overall, we highlight the ability of C. asiatica L. to affect brain functions by increasing Bdnf expression and by enhancing the cognitive performance.
Controlled-Release from High-Loaded Reservoir-Type Systems—A Case Study of Ethylene-Vinyl Acetate and Progesterone
Authors: Koutsamanis Ioannis , Paudel Amrit , Nickisch Klaus , Eggenreich Karin , Roblegg Eva , Eder Simone
Published: January 2020

Reservoir systems (drug-loaded core surrounded by drug-free membrane) provide long-term controlled drug release. This is especially beneficial for drug delivery to specific body regions including the vagina. In this study, we investigated the potential of reservoir systems to provide high drug release rates over several weeks. The considered model system was an intra-vaginal ring (IVR) delivering progesterone (P4) in the mg/day range using ethylene-vinyl acetate (EVA) as release rate-controlling polymers. To circumvent the high material needs associated with IVR manufacturing, we implemented a small-scale screening procedure that predicts the drug release from IVRs. Formulations were designed based on the solubility and diffusivity of P4 in EVAs with varying vinyl acetate content. High in-vitro P4 release was achieved by (i) high P4 solubility in the core polymer; (ii) high P4 partition coefficient between the membrane and the core; and/or (iii) low membrane thicknesses. It was challenging for systems designed to release comparatively high fractions of P4 at early times to retain a constant drug release over a long time. P4 crystal dissolution in the core could not counterbalance drug diffusion through the membrane and drug crystal dissolution was found to be the rate-limiting step. Overall, high P4 release rates can be achieved from EVA-based reservoir systems
Glacier Variations at Xinqingfeng and Malan Ice Caps in the Inner Tibetan Plateau Since 1970
Authors: Zhang Zhen , Liu Shiyin , Jiang Zongli , Shangguan Donghui , Wei Junfeng , Guo Wanqin , Xu Junli , Zhang Yong , Zhang Shasha , Huang Danni
Published: January 2020

The inner Tibetan Plateau is a glacierized region where glaciers show heterogeneous change. The Xinqingfeng and Malan ice caps are located in this region, and a transition zone exists with shifting influences between the westerlies and Indian summer monsoon. However, there is a lack of detailed information regarding glacier area and mass changes in this region before 2000. In the present study, we describe an integrated view of the glacier area and its mass changes for Mt. Xinqingfeng and Mt. Malan as derived from topographic maps, Landsat, ASTER, SRTM DEM, and TerraSAR-X/TanDEM-X from 1970 to 2012 and from 1970 to 2018, respectively. Our results show that the glaciers experienced a slight shrinkage in area by 0.09 ± 0.03% a−1 from 1970 to 2018 with a median mass loss rate of 0.22 ± 0.17 m w.e. a−1 and 0.29 ± 0.17 m w.e. a−1 between 1999 and 2012 at Mt. Xinqingfeng and Mt. Malan, respectively. The glaciers of Mt. Malan had a total mass loss of 0.19 ± 0.14 m w.e. a−1 during the period 1970–1999. A minimum of seven glaciers at Mt. Xinqingfeng and Mt. Malan showed heterogeneous variations with either surging or advancing during the observation period. Among them, the West Monuomaha Glacier, Monuomaha Glacier, and Zu Glacier were identified as surging glaciers, and the others may also be surging glaciers, although more evidence is required. These glaciers showed a long active period and low velocities. Therefore, we suggested that thermal controls are important for surge initiation and recession.
Design and Analysis of a Next-Generation Wide Field-of-View Earth Radiation Budget Radiometer
Authors: Schifano Luca , Smeesters Lien , Geernaert Thomas , Berghmans Francis , Dewitte Steven
Published: January 2020

Climate on Earth is determined by the Earth Radiation Budget (ERB), which quantifies the incoming and outgoing radiative energy fluxes. The ERB can be monitored by non-scanning wide field-of-view radiometers, or by scanning narrow field-of-view radiometers. We propose an enhanced design for the wide field-of-view radiometer, with as key features the use of a near-spherical cavity to obtain a uniform angular sensitivity and the integration of the shuttered electrical substitution principle, eliminating long term drifts of the radiometer and improving its time response. The target absolute accuracy is 1 W/m 2 and the target stability is 0.1 W/m 2 per decade for the measurement of the total outgoing Earth’s radiation. In order to increase the spatial resolution and to separate the total outgoing radiation into reflected Solar and emitted thermal radiation, we propose the joint use of the radiometer with wide field-of-view Shortwave (400–900 nm) and Longwave (8–14 μm) cameras. This paper presents the concept and design of the novel wide field-of-view radiometer, including simulations and analyses of its expected performance. We focus on mechanical design and the measurement characteristics based on optical and thermal analyses. In combination with the cameras, we obtain an estimated accuracy of 0.44 W/m 2 .
Landsat Analysis Ready Data for Global Land Cover and Land Cover Change Mapping
Authors: Potapov Peter , Hansen Matthew C. , Kommareddy Indrani , Kommareddy Anil , Turubanova Svetlana , Pickens Amy , Adusei Bernard , Tyukavina Alexandra , Ying Qing
Published: January 2020

The multi-decadal Landsat data record is a unique tool for global land cover and land use change analysis. However, the large volume of the Landsat image archive and inconsistent coverage of clear-sky observations hamper land cover monitoring at large geographic extent. Here, we present a consistently processed and temporally aggregated Landsat Analysis Ready Data produced by the Global Land Analysis and Discovery team at the University of Maryland (GLAD ARD) suitable for national to global empirical land cover mapping and change detection. The GLAD ARD represent a 16-day time-series of tiled Landsat normalized surface reflectance from 1997 to present, updated annually, and designed for land cover monitoring at global to local scales. A set of tools for multi-temporal data processing and characterization using machine learning provided with GLAD ARD serves as an end-to-end solution for Landsat-based natural resource assessment and monitoring. The GLAD ARD data and tools have been implemented at the national, regional, and global extent for water, forest, and crop mapping. The GLAD ARD data and tools are available at the GLAD website for free access.
Radiometric Degradation Curves for the ASTER VNIR Processing Using Vicarious and Lunar Calibrations
Authors: Tsuchida Satoshi , Yamamoto Hirokazu , Kouyama Toru , Obata Kenta , Sakuma Fumihiro , Tachikawa Tetsushi , Kamei Akihide , Arai Kohei , Czapla-Myers Jeffrey S. , Biggar Stuart F. , Thome Kurtis J.
Published: January 2020

The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) onboard Terra platform, which was launched in 1999, has three separate subsystems: a visible and near-infrared (VNIR) radiometer, a shortwave-infrared radiometer, and a thermal-infrared radiometer. The ASTER VNIR bands have been radiometrically corrected for approximately 14 years by the sensor degradation curves estimated from the onboard calibrator according to the original calibration plan. However, this calibration by the onboard calibrator encountered a problem; specifically, it is inconsistent with the results of vicarious calibration and cross calibration. Therefore, the ASTER VNIR processing was applied by the radiometric degradation curves calculated from the results of three calibration approaches, i.e., the onboard calibrator, the vicarious calibration, and the cross calibration since February 2014. Even though the current degradation curves were revised, the inter-band and lunar calibrations show some inconsistencies owing to the different traceability in the bands by different calibration approaches. In this study, the current degradation curves and their problems are explained, and the new curves that are derived from the vicarious calibration with lunar calibration are discussed. The new degradation curves that have the same traceability in the bands will be used for future ASTER VNIR processing.
Monitoring Mega-Crown Leaf Turnover from Space
Authors: Bush Emma R. , Mitchard Edward T. A. , Silva Thiago S. F. , Dimoto Edmond , Dimbonda Pacôme , Makaga Loïc , Abernethy Katharine
Published: January 2020

Spatial and temporal patterns of tropical leaf renewal are poorly understood and poorly parameterized in modern Earth System Models due to lack of data. Remote sensing has great potential for sampling leaf phenology across tropical landscapes but until now has been impeded by lack of ground-truthing, cloudiness, poor spatial resolution, and the cryptic nature of incremental leaf turnover in many tropical plants. To our knowledge, satellite data have never been used to monitor individual crown leaf phenology in the tropics, an innovation that would be a major breakthrough for individual and species-level ecology and improve climate change predictions for the tropics. In this paper, we assessed whether satellite data can detect leaf turnover for individual trees using ground observations of a candidate tropical tree species, Moabi (Baillonella toxisperma), which has a mega-crown visible from space. We identified and delineated Moabi crowns at Lopé NP, Gabon from satellite imagery using ground coordinates and extracted high spatial and temporal resolution, optical, and synthetic-aperture radar (SAR) timeseries data for each tree. We normalized these data relative to the surrounding forest canopy and combined them with concurrent monthly crown observations of new, mature, and senescent leaves recorded from the ground. We analyzed the relationship between satellite and ground observations using generalized linear mixed models (GLMMs). Ground observations of leaf turnover were significantly correlated with optical indices derived from Sentinel-2 optical data (the normalized difference vegetation index and the green leaf index), but not with SAR data derived from Sentinel-1. We demonstrate, perhaps for the first time, how the leaf phenology of individual large-canopied tropical trees can directly influence the spectral signature of satellite pixels through time. Additionally, while the level of uncertainty in our model predictions is still very high, we believe this study shows that we are near the threshold for orbital monitoring of individual crowns within tropical forests, even in challenging locations, such as cloudy Gabon. Further technical advances in remote sensing instruments into the spatial and temporal scales relevant to organismal biological processes will unlock great potential to improve our understanding of the Earth system.
A Novel Sensorised Insole for Sensing Feet Pressure Distributions
Authors: Sorrentino Ines , Andrade Chavez Francisco Javier , Latella Claudia , Fiorio Luca , Traversaro Silvio , Rapetti Lorenzo , Tirupachuri Yeshasvi , Guedelha Nuno , Maggiali Marco , Dussoni Simeone , Metta Giorgio , Pucci Daniele
Published: January 2020

Wearable sensors are gaining in popularity because they enable outdoor experimental monitoring. This paper presents a cost-effective sensorised insole based on a mesh of tactile capacitive sensors. Each sensor’s spatial resolution is about 4 taxels/cm 2 in order to have an accurate reconstruction of the contact pressure distribution. As a consequence, the insole provides information such as contact forces, moments, and centre of pressure. To retrieve this information, a calibration technique that fuses measurements from a vacuum chamber and shoes equipped with force/torque sensors is proposed. The validation analysis shows that the best performance achieved a root mean square error (RMSE) of about 7   N for the contact forces and 2   N m for the contact moments when using the force/torque shoe data as ground truth. Thus, the insole may be an alternative to force/torque sensors for certain applications, with a considerably more cost-effective and less invasive hardware.
RMS Delay Spread vs. Coherence Bandwidth from 5G Indoor Radio Channel Measurements at 3.5 GHz Band
Authors: Debaenst Wout , Feys Arne , Cuiñas Iñigo , García Sánchez Manuel , Verhaevert Jo
Published: January 2020

Our society has become fully submersed in fourth generation (4G) technologies, setting constant connectivity as the norm. Together with self-driving cars, augmented reality, and upcoming technologies, the new generation of Internet of Things (IoT) devices is pushing the development of fifth generation (5G) communication systems. In 5G architecture, increased capacity, improved data rate, and decreased latency are the objectives. In this paper, a measurement campaign is proposed; we focused on studying the propagation properties of microwaves at a center frequency of 3.5 GHz, commonly used in 5G cellular networks. Wideband measurement data were gathered at various indoor environments with different dimensions and characteristics. A ray-tracing analysis showed that the power spectrum is dominated by the line of sight component together with reflections on two sidewalls, indicating the practical applicability of our results. Two wideband parameters, root mean square delay spread and coherence bandwidth, were estimated for the considered scenarios, and we found that they are highly dependent on the physical dimension of the environment rather than on furniture present in the room. The relationship between both parameters was also investigated to provide support to network planners when obtaining the bandwidth from the delay spread, easily computed by a ray-tracing tool.
Identification of Factors Influencing Sustainability of Buried Continuous Pipelines
Authors: Akram Muhammad Rizwan , Can ZÜLFİKAR Abdullah
Published: January 2020

Threat to the sustainability of buried continuous pipelines (BCPs) can be associated with different factors such as corrosion, natural hazards, and third-party influences. In the past, these factors have been discussed independently by various researchers. Despite these studies, there is still space for a comprehensive review report to be performed in this domain. The purpose of this article is to manage, classify, and describe the literature work done in this sphere. Firstly, the screening of various factors based on their damage criteria has been carried out. An environmental analysis is performed to review the impact of different parameters that can influence the sustainability of BCPs. Further, a technical review on primary factors has been done to examine and measure the causes, damages, mitigation, and inspection techniques. In the last stage, review based decision has been performed. Results of the current study shows that research contribution for corrosion and earthquake factors are in an advanced stage, followed by flood and external surface loads, that are still in progress. However, temperature variations and blast factors are in a premature phase and need broad inspection and research support.
Case Study of Support Frame Optimization Using a Distant Load
Authors: Lonkwic Paweł , Przystupa Krzysztof , Krakowski Tomasz , Ruta Hubert
Published: January 2020

This article presents the results of the structure optimization for the power unit carrying frame of a friction lift by means of numerical calculations using the finite element method (FEM). Optimization analysis covered the frame structure. The analysis was focused on strength optimization with the use of a remote load and on manufacturing optimization with attention paid to the operating times necessary to complete the production process of the carrying frame subassemblies. The Solidworks simulation program was used to optimize the frame in terms of the strength criterion. The program allowed both quantitative and qualitative assessments of the frame material effort before and after optimization.
Comparative Analysis of Economic Impacts of Sustainable Vertical Extension Methods for Existing Underground Spaces
Authors: Seo Soo-yeon , Lee Byunghee , Won Jongsung
Published: January 2020

Without demolishing an entire existing building, it is possible to sustainably expand its underground spaces to enhance the building’s functionality. However, there have been a few relevant studies exploring this option, and they did not consider the financial feasibilities of underground vertical extension methods. Therefore, this paper analyzes the economic impacts of three sustainable vertical extension methods for existing underground spaces. The extension methods were the (1) bottom-up, (2) normal top-down, and (3) top-down with multi-post downward (MPD) methods. In order to analyze and compare the economic impacts of the underground vertical extension methods, 24 illustrative examples were generated in this paper. Construction costs of the three sustainable vertical extension methods for existing underground spaces are calculated and compared. Those are based on the quantity of used materials in the construction phase and dismantled materials in the demolition phase, as well as unit costs of each material. In addition, the structural stabilities of the examples are analyzed using MIDAS Gen 2017. As the results, the top-down method with MPD was the lowest sustainable method for vertically expanding underground spaces compared to other two methods under the same condition. Moreover, the higher the number of underground floors of existing buildings and the greater the number of extended basement floors, the more economically advantageous was the top-down method with MPD. Considering their structural stabilities and economic impacts of the extension methods help practitioners to select appropriate construction techniques and reduce costs, risks, and the amount of generated construction and demolition waste.
Multi-Scale Evaluation of Suzhou City’s Sustainable Development Level Based on the Sustainable Development Goals Framework
Authors: Lin Weixing , Hong Changqiao , Zhou Yinkang
Published: January 2020

A sustainable development system involves resource limitation, environmental stress and policy regulation, and the flow and integration of resources and factors on a multi-level spatial scale. However, it is difficult to meet the actual needs of local development through traditional single-scale and macro-scale evaluation of the comprehensive level. Taking Suzhou City as an example, based on the United Nations (UN) sustainable development goals (SDGs) framework, the entropy method and fuzzy comprehensive evaluation (FCE) were used to construct an evaluation index system of the municipal sustainable development level. Growth and obstacles of the sustainable development system and its subsystems were systematically analyzed on a multi-level spatial scale. Results show that during the study period (2000-2016), the sustainable development system in Suzhou was relatively low at the beginning of the study. With the passage of time, it generally developed in a stable, continuous, and balanced direction. The levels of development, deficiencies, and obstacle factors of sustainable development systems and their subsystems are significantly different between levels; especially during the study period, the order change between towns is significantly higher than the order change between districts. Within an evaluation unit, there is a process of rising and continuing growth among certain subsystems, but some subsystems have been developing slowly due to resource constraints, environmental load, etc., or their contribution to the level of sustainable development has remained low. The city sustainable development evaluation index system based on the SDGs framework can meet the requirements of regional assessment and has the potential for further promotion and use. The evaluation results can provide a necessary reference for the subsystem coordination, scale linkage, and resource space allocation of the sustainable development system in Suzhou.