bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutritional, anti-nutritional and morphological characterization of wild edible species of Solanum found in North East India
Authors: Ningthoujam Rina , Deo Chandra , Phurailatpam Arunkumar , BN Hazarika , Bhutia Nangsol Dolma , Heisnam Punabati , Mayanglambam Chandrakumar , SINGH YENGKHOM DISCO
Published: July 2023

The outcome of this study shows that S. species are considerably variate in nutritional, anti-nutritional and morphological characters. Maximum plant height (161.16±5.67 cm) and number of flowers per inflorescence (12.49±1.55) was obtained from S. torvum while S. nigrumattained minimum fruit length (6.08±0.43 mm) and girth (6.48±0.55 mm). Among all the berries, S. macrocarpon has wider girth than length. So, it perceived maximal fruit girth (73.65±0.65 mm) and lowest number of flowers per inflorescence (2.04±0.43). Being a short period plant, S. nigrum also recorded least number of days to first flowering (19.94±3.63) and no. of days taken for fruit development (31.27±2.99). Regarding nutritional composition, highest amount of total carbohydrates (47.44±1.75 mg/g) and starch (8.76±0.16 mg/g) was recorded in S. macrocarpon whereas it has least value of cellulose (0.75±0.007 mg/g). S. ferox achieved maximal amount of total sugar (7.33±0.78 mg/g) and reducing sugar (3.86±0.40 mg/g). Likewise, S. spirale recorded minimum amount of total sugar (2.37±0.12 mg/g) and reducing sugar (0.23±0.03 mg/g) while S. torvum obtained highest quantity of cellulose (2.04±0.08 mg/g). Total soluble protein was observed from S. villosum with an amount of 1.54±0.03 mg/g whereas S. gilo (white) obtained lowest 0.74±0.03 mg/g soluble protein. As for anti-nutritional highest quantity of phytic acid was recorded in S. spirale (5.34 ±0.18 mg/g) while least amount was obtained from S. ferox(0.72 ±0.01 mg/g). However, maximal amount of cyanogen i.e., 54.24 ±0.59 µg/g was attained from S. violaceum(spineless) and lowest quantity of cyanogen at 12.72 ±0.56 µg/g was recorded in S. gilo (green).
Data Protection Using Optical System and Steganography Tool
Authors: Patra Anirban , Saha Arijit , Roy Samiran
Published: July 2023

Steganography, which is the art of hiding secret information, is widely used by researchers for the last few decades. However, maximum people use commercially available stenography tools due to their easy availability. In most of these tools, it is quite easy to decrypt hidden information using a different process. Hence, it is a difficult task to securely communicate personal information using this type of steganography tool. In this communication, we propose a novel encryption process of hidden information into the stage images and texts in the optical system (grating). The entire encryption process is divided into two stages. First, the images and texts are hidden into other images using the commercially available steganographic tool, Steghide, and then modulated in the optical grating system. In the second part, the resultant object is further processed by the random phase matrix. We tested in different decryption software and observed that the hidden image and text cannot be successfully decrypted. Therefore. this process can be used effectively to secure hidden information in the steganographic process.
How do Children with Developmental Dyslexia Integrate Sentence-Picture Information?
Authors: Shi Duyuan , Yang Mengting , Yao Ru , Li Tingyu , Zhang Hongxia
Published: July 2023

Children with developmental dyslexia have significant defects in reading, and many researches show that the form of information presentation will have different effects on individual reading efficiency. This study has adopted a mixed design of 2 (subject group: children with developmental dyslexia, typical development children)×3 (sentence style: affirmative, negative, double-negative)×2 (picture information complexity: simple, complex) to investigate the sentence-picture information integration capability of children with developmental dyslexia, and explore whether children with developmental dyslexia have defects in the ability to integrate sentence-picture information. The results showed that: 1. Sentence style had a significant effect on the integration process, and the reading efficiency of both groups decreased with the increase of sentence structure complexity in all three sentence styles; 2. Picture information complexity had a significant effect on the integration process, and both groups were more efficient in integrating sentence-picture in the simple condition than in the complex condition; 3. Children with developmental dyslexia haddefects in the ability to integrate sentence-picture information. Conclusion: For children with developmental dyslexia, simple sentences, such as affirmative sentences with simple picture information without distractions, can be presented as far as possible to improve their reading efficiency.
Experimental Study of 3D Printing Technique Combined with Biphasic Calcium Phosphates in the Treatment of Canine Model of Osteonecrosis of the Femoral Head
Authors: chen zhian , Feng Fanzhe , Su Xixiong , Xu Yongqing , Zhang Ying , Tan Hongbo
Published: July 2023

Objective:This study attempts to use a digital design of 3D printing technology to create a surgical navigation template. At the same time, biphasic calcium phosphates (BCP) were used in the treatment of animal models of osteonecrosis of the femoral head (ONFH) basis on accurate positioning of necrotic lesions in the navigation templates and observing its therapeutic effect.
Methods:15 healthy adult beagle dogs of male and female, weight (20 + 2) kg, after establishing the model of ONFH using liquid nitrogen freezing method, were randomly divided into 3 groups (n=5). Each model underwent necrosis lesions and BPC implantations in one side of femoral head, and only underwent necrosis lesions in one other side of femoral head. Each group underwent CT examination, gross observation,histological examination and immunohistochemical staining at 6 weeks, 12 weeks and 18 weeks postoperatively.
Results:At weeks 6, 12, and 18, CT and gross examination showed that the necrotic area in the experimental group was basically intact and had been completely raised by BCP material. In the control group, there were signs of bone repair in the femoral head, but there were still large bone defects and cavities,At week 18, extensive collapse of the cartilage surface was observed.Through histological examination, in the experimental group at 12 and 18 weeks, a large number of new and reconstructed bone trabeculae containing a large amount of collagen fibers were observed (P<0.05), while in the control group, there was extensive necrosis of the bone trabeculae without cellular structural areas.Immunohistochemical examination observation: A large number of CD31 positive cells were observed in the experimental group at 6 weeks, gradually decreasing at 12 and 18 weeks (P<0.05), while a small number of CD31 positive cells were observed in the control group at 18 weeks.
Conclusion:3D printing navigation template can accurately locate the ONFH lesions. Implantation of BCP material can effectively play a supporting role, prevent the collapse of the loading surface, and induce bone formation and angiogenesis to some extent.
Preoperative fluorescent clip marking vs. India ink tattooing for tumor identification during colorectal surgery
Authors: Kitagawa Takahiro , Ryu Shunjin , Goto Keisuke , Okamoto Atsuko , Marukuchi Rui , Hara Keigo , Ito Ryusuke , Nakabayashi Yukio
Published: July 2023

Purpose
Identifying tumor location is important in colorectal tumor resection. Preoperative endoscopic India ink marking is a widespread practice, but local injection of ink is an unstable procedure. Although it is often invisible, the ink may be sprayed into the peritoneal cavity and contaminate the surgical field. At our hospital, we introduced fluorescent clip marking (FCM) using the Zeoclip FS®, an endoscopic clip developed using near-infrared fluorescent resin. We tested the usefulness of FCM by retrospectively comparing cases in which FCM was used with cases in which conventional ink marking was used.
Methods
We enrolled 305 patients with colorectal tumors who underwent colorectal surgery after preoperative marking from January 2017 to April 2022. We classified the patients into the FCM group (86 patients) and the India ink tattoo group (219 patients). Endoscopic marking was completed in the FCM group by the day before surgery, and fluorescence was evaluated during surgery with a fluorescent laparoscopic system. Patient backgrounds, marking visibility, adverse effects, and early postoperative results were retrospectively compared between groups.
Results
Marking was visually confirmed in 80 patients in the FCM group (93.02%) and in 166 patients in the India ink tattoo group (75.80%) (p = 0.0006). In the group with India ink tattoos, contamination of the surgical field was observed in seven cases (3.20%). No adverse events were observed in the FCM group.
Conclusion
In colorectal surgery, FCM provides better visibility than the conventional India ink tattooing method and is a simple and safe marking method.
Clinical trial registration
Examination of fluorescence navigation for laparoscopic colorectal cancer surgery.
Research Ethics Committee of the Kawaguchi Municipal Medical Center (Saitama, Japan) approval number: 2020-3. https://kawaguchi-mmc.org/wp-content/uploads/clinicalresearch-r02.pdf.
Determination of Ir(III) by Its Catalytic Effect on the Oxidation of Valine by HCF(III) in Aqueous Alkaline Medium- A Kinetic Spectrophotometric Method
Authors: Rajput Shakunj , Lasyal Rajni
Published: July 2023

A simple and sensitive spectrophotometric method has been developed for the determination of trace amounts of Ir(III). The method is based on the Ir(III) catalyzed oxidation of valine by HCF(III) in aqueous alkaline medium. Under the optimum experimental conditions, Beer’s law is obeyed in the range 1.99–19.98 µg ml− 1 of Ir(III) for valine with a maximum average error of 99.5% and maximum relative standard deviation of 1.702%. The value of the correlation coefficient lies between 0.999 to 0.980. The effect of few interfering ions has been worked out for developing the calibration curves in terms of absorbance or reaction rate or pseudo-first-order rate constant vs. [Ir (III)] plot, absorbance was noted at λmax of 420 nm. The molar absorptivity and Sandell’s sensitivity are found to be 0.9 x 103 to 1.2 x 103 lmol− 1cm− 1 and 0.216 to 0.213 µgcm− 2 respectively. The results show that the present method is more simple and more sensitive than the reported methods and especially useful in the absence of expected interfering ions. The standard deviations estimated from six independent determinations in a sample of Ir(III) are 0.088 to 0.11.
In Vitro Antiviral Activity of NanB Bacterial Sialidase Against Avian Influenza H9N2 Virus in MDCK cells
Authors: Nugroho Christian Marco Hadi , Silaen Otto Sahat Martua , Kurnia Ryan Septa , Krisnamurti Desak Gede Budi , Carnell George William , Putra Muhammad Ade , Indrawati Agustin , Poetri Okti Nadia , Wibawan I Wayan Teguh , Widyaningtyas Silvia Tri , Soebandrio Amin
Published: July 2023

The authors have requested that this preprint be removed from Research Square.
Study of fire behavior and evacuation in tunnel by simulation
Authors: Purwar Parth , Shukla Naman , Thanekar Arpit Thanekar , A.B Bharath , Bansod Shail , Bhattacharya Shantanu , Singh D.K.
Published: July 2023

Over the past few decades, fire protection in tunnels is becoming very important as tunnels are gaining more popularity. It is constructed and used for transportation by people and freight all over the world. In order to achieve a fire safety purpose, evacuation systems should be well designed and built to evacuate people as early and safely as possible. The objective of this paper is to investigate the fire behavior and evacuation in a tunnel based on numerical simulation models in a longitudinally ventilated tunnel. In this study, a single fire caused by vehicles carrying different fire loads is been considered and simulated along with multiple varying conditions, where installation of Heating Ventilation and Air Conditioning (HVAC’s) and its capability of reversing the spread of smoke i.e., to prevent back layering is been checked. FDS simulation modelling tool was also majorly used to investigate the dangerous situations in which a fully loaded gasoline tank lorry was considered for burning simulation inside a long road tunnel. These simulation results were used to determine conditions which are faced by humans while evacuating any road tunnel that’s under fire. In this paper, multiple model-based experiments were carried out using tunnels of different sizes and ventilation conditions.
Black seeds (Nigella sativa) for the management of Dengue viral disease: POM analyses for the identification of new antiviral pharmacophore sites
Authors: Maideen Naina Mohamed Pakkir , Hadda Taibi Ben , Almalki Faisal A. , Laarousi Hamid , Soliman Sameh S.M. , Kawsar Sarkar M.A.
Published: July 2023

The number of Dengue virus (DENV) infection cases has increased dramatically over the past two decades with an estimate of 3.9 billion cases across the globe are potentially at risk. Patients with a DENV infection are managed symptomatically and by supportive care since there is no approved antiviral drug yet for its management. On the other hand,Nigella sativahas been highlighted as a potential antiviral particularly against DENV. Hence, the anti-DENV potential ofN. sativais analyzed in this review using major databases including Medline/PMC/PubMed, Scopus, EBSCO, EMBASE, Google Scholar, and Science Direct. Moreover, the Petra/Osiris/Molinspiration (POM) bioinformatics platform-2019 was used to analyze a series of compounds (1-15) identified inN. sativa(the Black seeds) to identify those with promising antiviral pharmacophore sites. Preliminary research showed the potential ofN. sativain the control ofAedes aegyptimosquitoes and the enhancement of platelet counts. Besides, several clinical, animal,in vitroandin vivostudies have demonstrated the antiviral, immunomodulatory and antiinflammatory properties ofN. sativa. Furthermore, calculation of the physico-chemical properties ofN. sativacompounds using POM analyses indicated that dithymoquinone possesses a potential antiviral activity with two (O, O’) pharmacophore sites. As a result,N. sativacan be employed as an adjuvant/ supportive therapy in the management of DENV infection in the early stages of the illness. Furthermore,N. sativacan be a source of new lead anti-DENV drug.
Regionalization methods for PUB: a comprehensive review of progress after the PUB decade
Authors: Yang Xue , Li Fengnian , Qi Wenyan , Zhang Mengyuan , Yu Chengxi , Xu Chong-Yu
Published: July 2023

This paper presents an updated review of model-dependent regionalization methods in hydrology since the PUB decade, incorporating new regions and methodological advancements. Two categories of regionalization methods are discussed: distance-based and regression-based, with various modification approaches. Several factors affecting the accuracy of regionalization performance are identified, including hydrological models, climate characteristics, data availability, and regionalization techniques. The review concludes that distance-based regionalization methods with an output averaging option from multiple donor catchments are the most statistically reliable, and a threshold of 0.5–0.8 for donor selection is optimal for performance. The parsimonious hydrological model is also recommended, particularly in data-limited contexts. Other insights include the effectiveness of the ensemble concept and limited impact of prior classification. Additionally, it is found that the general performance difference between climatic classes is larger than between methods, and regression-based methods may have large uncertainties in tropical regions. Overall, this study provides practical guidance for improving regionalization studies and advancing the field of hydrology.
Contemporary Trends in Active and Intelligent Polymer Nanocomposite
based Food Packaging Systems for Food Safety and Sustainability in the
Modern Aeon
Authors: Pawar Jayant Rajaram , Phatak Rohan Sharadanand , Qureshi Nilam Mehmood. , Singh Athoiba Elangbam , Shinde Manish Dipakrao , Amalnerkar Dinesh Pundalik , Doh Jaehyeok
Published: July 2023

The demand for innovative solutions has arisen from the inevitability of improved
packaging systems to protect processed food from various factors that cause spoilage. Traditional
food packaging materials have limitations in fulfilling all the requirements of consumers, such as
being inert, cheap, lightweight, easily degradable, reusable, and resistant to physical abuse. Nanofillers
incorporated in the polymer matrix can provide potential solutions to these challenges. This
review paper deliberates the use of nanofillers in a polymer matrix to develop an active and intelligent
polymer nanocomposites-based processed food packaging system. The present review article
focuses on the properties of nanofillers and their potential benefits when incorporated into the
polymer matrix. It also examines the challenges associated with developing such packaging systems
and explores the ways to address them. It highlights the potential of nanofiller-based polymer
nanocomposites in developing a novel food packaging system that can improve the shelf-life
and quality of processed food. Such systems can protect food from dirt or dust, oxygen, light,
moisture, and food-spoiling microorganisms. Incorporating nanofillers can provide a viable solution
to these problems. Most importantly, this paper provides research insights into the potential
benefits of nanofillers-based polymer nanocomposites and their applications in the food packaging
industry. The verdicts of this review will be of interest to the food packaging industry, entrepreneurs
and researchers interested in developing sustainable and innovative packaging systems.
Contemporary development of nature-based tourism – characteristics and study aspects
Authors:   Agency for Mobility and EU Programmes, Zagreb, Croatia, Žafran Ivana
Published: July 2023

Nature-based tourism is a type of tourism that is primarily concerned with the direct enjoyment of relatively undisturbed natural phenomena. Today, it is among the types of tourism which are characterised by significant growth rates at the global level. It has considerable growth potential and its development can concurrently ensure tourist satisfaction with the nature experience, profit for tourism providers, funds for environmental protection and an improvement in living standards in local communities. Nevertheless, it is also important to be aware of the potential negative implications of nature-based tourism development and to continuously manage all aspects of sustainability. This paper aims to determine the main study aspects of nature-based tourism, the most common methodological approaches and the most important characteristics of its contemporary development. For this purpose, an analysis of recent empirical research on nature-based tourism was conducted, and a total of 41 original scientific papers were included in the analysis. The four study aspects derived from this analysis contribute to determining the general characteristics of nature-based tourism's contemporary development, the prerequisite factors for this development, and the effects it has on a given area.
Evaluating a Novel Infant Heart Rate Detector for Neonatal Resuscitation Efforts: Protocol for a Proof-of-Concept Study (Preprint)
Authors: Abdou Abdelrahman , Krishnan Sridhar , Mistry Niraj
Published: July 2023

BACKGROUND

Over 10 million newborns worldwide undergo resuscitation at birth each year. Pediatricians may use electrocardiogram (ECG), pulse oximetry (PO), and stethoscope in determining heart rate (HR), as HR guides the need for and steps of resuscitation. HR must be obtained quickly and accurately. Unfortunately, the current diagnostic modalities are either too slow, obtaining HR in more than a minute, or inaccurate. With time constraints, a reliable robust heart rate detector (HRD) modality is required. This paper discusses a protocol for conducting a methods-based comparison study to determine the HR accuracy of a novel real-time HRD based on 3D-printed dry-electrode single-lead ECG signals for cost-effective and quick HR determination. The HRD’s HR results are compared to either clinical-grade ECG or PO monitors to ensure robustness and accuracy.

OBJECTIVE

The purpose of this study is to design and examine the feasibility of a proof-of-concept HRD that quickly obtains HR using biocompatible 3D-printed dry electrodes for single-lead neonatal ECG acquisition. This study uses a novel HRD and compares it to the gold-standard 3-lead clinical ECG or PO in a hospital setting.

METHODS

A cross-sectional study is planned to be conducted in the neonatal intensive care unit or postpartum unit of a large community teaching hospital in Toronto, Canada, from June 2023 to June 2024. In total, 50 newborns will be recruited for this study. The HRD and an ECG or PO monitor will be video recorded using a digital camera concurrently for 3 minutes for each newborn. Hardware-based signal processing and patent-pending embedded algorithm-based HR estimation techniques are applied directly to the raw collected single-lead ECG and displayed on the HRD in real time during video recordings. These data will be annotated and compared to the ECG or PO readings at the same points in time. Accuracy, F1-score, and other statistical metrics will be produced to determine the HRD’s feasibility in providing reliable HR.

RESULTS

The study is ongoing. The projected end date for data collection is around July 2024.

CONCLUSIONS

The study will compare the novel patent-pending 3D-printed dry electrode–based HRD’s real-time HR estimation techniques with the state-of-the-art clinical-grade ECG or PO monitors for HR accuracy and examines how fast the HRD provides reliable HR. The study will further provide recommendations and important improvements that can be made to implement the HRD for clinical applications, especially in neonatal resuscitation efforts. This work can be seen as a stepping stone in the development of robust dry-electrode single-lead ECG devices for HR estimations in the pediatric population.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/45512
Implementing and Maintaining a SARS-CoV-2 Exposure Notification Application for Mobile Phones: The Finnish Experience (Preprint)
Authors: Pihlajamäki Mika , Wickström Sara , Puranen Kaija , Helve Otto , Yrttiaho Aleksi , Siira Lotta
Published: July 2023

UNSTRUCTURED

Exposure notification applications (ENAs) or digital proximity tracing apps were used in several countries during the COVID-19 pandemic. In this viewpoint, we share our experience of implementing and running the Finnish ENA (Koronavilkku), one of the national ENAs with the highest proportion of users during the pandemic. With the aim of strengthening public trust and increasing app uptake, there was a strong prioritization of privacy and data security for the end user throughout the ENA development. This, in turn, limited the use of the app as a tool for health care professionals and deeper insight into its potential effectiveness. The ENA was designed to supplement conventional contact tracing, rather than replace it, and to serve as an early warning system and a trigger for action for the user in case of potential exposure. The predefined target of 40% uptake in the population was achieved within 3 months of the ENA launch. We consider easy-to-understand information produced together with communication experts crucial during the changing pandemic situation. This information educated people about the app as one component in mitigating the pandemic. As the pandemic and its mitigation evolved, the ENA also needed adapting and updating. A few months after its launch, Finland joined European interoperability, which allowed the ENA to share information with ENAs of other countries. We added automatic token issuing to the ENA as of mid-2021. If added earlier and more comprehensively, automatization could have more effectively saved resources in health care services and prevented overburdening contact tracing teams, while also notifying potentially exposed individuals quicker and more reliably. In the spring of 2021, the number of active apps started to gradually decline. Quarantine and testing practices for asymptomatic vaccinated individuals following exposure to the virus were eased and home tests became more common, eventually replacing laboratory testing for much of the population. Taken together, this led to decreased token issuance, which weakened the potential public health usefulness of the app. A self-service option for token issuance would likely have prolonged the lifespan of the app. The ENA was discontinued in mid-2022. Regularly conducted surveys would have helped gain timely knowledge on the use and effectiveness of the app for better responding to the changing needs during the pandemic.
Patients and Clinicians Concurrent Views on Using Video Consultations in Mental Health Outpatient Services: Qualitative Analysis (Preprint)
Authors: Shaker Ali Abbas , Austin Stephen F. , Tarp Kristine , Borisov Radoslav Aleksandrov , Bechmann Henrik , Sørensen John Aasted , Simonsen Erik
Published: July 2023

BACKGROUND

Over the last decade, there has been an increase in the evidence base supporting the efficacy of video consultations (VC) in mental health services. Furthermore, the COVID-19 pandemic has also demonstrated the potential of virtual treatment. Despite these promising results and conducive conditions for VC, several studies have highlighted that the uptake and implementation of VC continues to be slow, even post-pandemic. In order to facilitate and strengthen the implementation of VC and exploit its potential as a useful tool for mental health disorder treatment, there is a need for a deeper understanding of the issues and experiences of implementing and using VC as a treatment modality in clinical practice.

OBJECTIVE

To investigate patients' and clinicians' experiences and attitudes toward using VC in clinical practice.

METHODS

Qualitative interviews were conducted with patients (n=10) and clinicians (n=4) who participated in weekly virtual treatment over two months within a mental health outpatients services in Denmark. Data from these semi-structured interviews with patients and focus group interviews with clinicians were explored through thematic analysis.

RESULTS

Common themes constructed from the patient interviews yielded two main themes; (1) Adjusting to the practicality of the VC format and (2) The practice of therapy using VC. Patients experienced that using VC was easy and convenient, increased their treatment engagement, and helped establish and maintain a therapeutic alliance.
The thematic analysis conducted on clinicians' experience with VC yielded three themes; (1) A change of mindset from resistance to one of acceptance, (2) The contact is different on video, and (3) A new way of working. Clinicians experienced their initial concerns and resistance towards VC implementation gradually diminishing, and gaining clinical experience using VC is a prerequisite for a successful VC implementation in mental health services.

CONCLUSIONS

Both patients and clinicians experienced that VC enhanced access to treatment and could be meaningfully integrated into clinical practice. This study also found clinicians expressed initial concerns and some resistance towards VC, but this diminished with the utilization of VC. Future research is needed to facilitate clinicians' use of VC in clinical practice.
Physician and Practice Characteristics Influencing Telemedicine Uptake Among Frontline Clinicians in the Early COVID-19 Pandemic Response: National Survey Study (Preprint)
Authors: Hamline Michelle Y , Xing Guibo , Kravitz Richard L , Miller Marykate , Melnikow Joy
Published: July 2023

BACKGROUND

 Telemedicine expanded rapidly during the COVID-19 pandemic, as key policy changes, financial support, and pandemic fears tipped the balance toward internet-based care. Despite this increased support and benefits to patients and clinicians, telemedicine uptake was variable across clinicians and practices. Little is known regarding physician and institutional characteristics underlying this variability.

OBJECTIVE

 This study aimed to evaluate factors influencing telemedicine uptake among frontline physicians in the early pandemic response.

METHODS

 We surveyed a national stratified sample of frontline clinicians drawn from the American Medical Association Physician Professional Data in June or July 2020. The survey inquired about the first month and most recent month (June 2020) of pandemic telemedicine use; sample data included clinician gender, specialty, census region, and years in practice. Local pandemic conditions were estimated from county-level data on COVID-19 rates at the time of survey response. Data were analyzed in a weighted logistic regression, controlling for county-specific pandemic data, and weighted to account for survey data stratification and nonresponse.

RESULTS

 Over the first 3-4 months of the pandemic, the proportion of physicians reporting use of telemedicine in >30% of visits increased from 29.2% (70/239) to 35.7% (85/238). Relative to primary care, odds of substantial telemedicine use (>30%) both during the first month of the pandemic and in June 2020 were increased among infectious disease and critical care physicians and decreased among hospitalists and emergency medicine physicians. At least minimal prepandemic telemedicine use (odds ratio [OR] 11.41, 95% CI 1.34-97.04) and a high 2-week moving average of local COVID-19 cases (OR 10.16, 95% CI 2.07-49.97) were also associated with substantial telemedicine use in June 2020. There were no significant differences according to clinician gender, census region, or years in practice.

CONCLUSIONS

 Prepandemic telemedicine use, high local COVID-19 case counts, and clinician specialty were associated with higher levels of substantial telemedicine use during the early pandemic response. These results suggest that telemedicine uptake in the face of the pandemic may have been heavily influenced by the level of perceived threat and the resources available for implementation. Such understanding has important implications for reducing burnout and preparation for future public health emergencies.
Race, Ethnicity, and Other Cultural Background Factors in Trials of Internet-Based Cognitive Behavioral Therapy for Depression: Systematic Review (Preprint)
Authors: De Jesús-Romero Robinson , Holder-Dixon Amani R , Buss John F , Lorenzo-Luaces Lorenzo
Published: July 2023

BACKGROUND

There is a growing interest in developing scalable interventions, including internet-based cognitive behavioral therapy (iCBT), to meet the increasing demand for mental health services. Given the growth in diversity worldwide, it is essential that the clinical trials of iCBT for depression include diverse samples or, at least, report information on the race, ethnicity, or other background indicators of their samples. Unfortunately, the field lacks data on how well diversity is currently reported and represented in the iCBT literature.

OBJECTIVE

Thus, the main objective of this systematic review was to examine the overall reporting of racial and ethnic identities in published clinical trials of iCBT for depression. We also aimed to review the representation of specific racial and ethnic minoritized groups and the inclusion of alternative background indicators such as migration status or country of residence.

METHODS

Studies were included if they were randomized controlled trials in which iCBT was compared to a waiting list, care-as-usual, active control, or another iCBT. The included papers also had to have a focus on acute treatment (eg, 4 weeks to 6 months) of depression, be delivered via the internet on a website or a smartphone app and use guided or unguided self-help. Studies were initially identified from the METAPSY database (n=59) and then extended to include papers up to 2022, with papers retrieved from Embase, PubMed, PsycINFO, and Cochrane (n=3). Risk of bias assessment suggested that reported studies had at least some risk of bias due to use of self-report outcome measures.

RESULTS

A total of 62 iCBT randomized controlled trials representing 17,210 participants are summarized in this study. Out of those 62 papers, only 17 (27%) of the trials reported race, and only 12 (19%) reported ethnicity. Reporting outside of the United States was very poor, with the United States accounting for 15 (88%) out of 17 of studies that reported race and 9 (75%) out of 12 for ethnicity. Out of 3,623 participants whose race was reported in the systematic review, the racial category reported the most was White (n=2716, 74.9%), followed by Asian (n=209, 5.8%) and Black (n=274, 7.6%). Furthermore, only 25 (54%) out of the 46 papers conducted outside of the United States reported other background demographics.

CONCLUSIONS

It is important to note that the underreporting observed in this study does not necessarily indicate an underrepresentation in the actual study population. However, these findings highlight the poor reporting of race and ethnicity in iCBT trials for depression found in the literature. This lack of diversity reporting may have significant implications for the scalability of these interventions.

CLINICALTRIAL
High-Pressure Processing Helps Meet the Escherichia coli O157:H7 and Shiga Toxin–Producing E. coli (STEC) Performance Standards for Beef Summer Sausage
Authors: Rigdon Macc , Thippareddi Harshavardhan , Thomas Chevise L. , Kumar Sanjay , McKee Robert W. , Stelzleni Alexander M.
Published: July 2023

The United States Department of Agriculture–Food Safety Inspection Service (USDA-FSIS) performance standards require that manufacturers of fermented beef sausages validate their processes to achieve a 5-log reduction of Escherichia coli O157:H7 and Shiga toxin–producing E. coli (STEC). Most processors rely on rapid fermentation to a low pH and a mild heat treatment to achieve the lethality performance standard. However, this process alters the sensorial characteristics of traditional fermented sausages. An alternative method to achieve lethality using high-pressure processing (HPP) during the manufacture of summer sausage with higher pH (5.0) and minimal heat treatment was evaluated. Sausages inoculated with circa 9.1 log CFU/g of E. coli O157:H7 and 8.9 log CFU/g of STEC were fermented to target pH values of 4.6 or 5.0. Subsequently, fermented sausages were heated to endpoint temperatures of 54.4°C, 48.9°C, or 43.3°C to the total process treatments of (1) Process A: pH 4.6 and 54.4°C, simulated cold air chilling, (2) Process B: pH 5.0 and 54.4°C, simulated cold air chilling, (3) Process C: pH 5.0 and 54.4°C, ice bath chilling, (4) Process D: pH 5.0 and 48.9°C, ice bath chilling, and (5) Process E: pH 5.0 and 43.3°C, ice bath chilling. After processing, the product was subjected to HPP (586 MPa; 4°C±2°C) for hold times of 1, 150, or 300 s and a nontreated (no HPP) control. All treatments subjected to HPP for 150 and 300 s reduced (P≤0.05) E. coli (O157:H7 and STEC) populations by>5.0 log CFU/g and >7.5 logCFU/g, respectively. The use of HPP allows for the production of more mild beef summer sausage (pH 5.0 and a mild thermal treatment of 43.3°C) while still achieving USDA-FSIS performance standards for lethality.
IoT Based Patient Healthcare Monitoring System
Authors: Naveena Dr. Ambidi
Published: July 2023

Abstract: The need for a health care monitoring system that provides instant sensing and precise predictions with prompt response is highly required. Recently, health care sensors are playing a key role in hospitals and home care for patients. The patient monitoring systems has become one of the most advanced technologies because of its ability to provide a higher level of information about the patient's condition The prototype model designed for the healthcare monitoring system is based on three main objectives: to monitor various physical parameters of patients, to detect if any emergency has occurred to the patient and to reduce the workload on the hospital staff. Physical parameters of the patients like pulse per minute and body temperature are sensed using biosensors like pulse rate sensor and LM35 sensor respectively. The sensor values are displayed on the LCD for constant monitoring. A buzzer is turned ON and an alert notification is sent to the caretaker, if any of the values crosses the threshold, indicating an emergency. A graphical representation is also displayed on the IoT platform for past analysis. An accelerometer is usedin this system to sense the movements of the patients and detect any fall or injury for senior citizens who prefer to stay at home and live independently, the system can communicate with caretakers to request for help if needed.
Тенденции развития жилищного рынка и жилищного строительства в регионах России в 2022 году
Authors: Стерник Сергей Геннадьевич , Мальгинов Георгий Николаевич
Published: July 2023

В работе проведены качественный и количественный анализ актуальных тенденций развития наряду с ценовым анализом жилищного рынка и рынка жилищного строительства на фоне серьезных геополитических изменений социально-экономической ситуации в России в 2022 г. В ходе исследования автор использовал методологию дискретного пространственно-параметрического моделирования рынка недвижимости. Помимо исследования ценовых показателей рынка в статье рассмотрены динамика и структура ввода жилья в регионах РФ, дана оценка специфики текущей ситуации в секторе жилищного строительства, изучено влияние мер государственной поддержки отрасли и выявлены факторы, оказывающие наибольшее влияние на перспективы развития отрасли в 2023 г. На основании проведенных авторских исследований сформулированы основные особенности отечественных рынков жилой недвижимости и жилищного строительства в 2022 г. Актуальность данной работы предопределяется значительной востребованностью научного метода анализа существующих рисков и влияния фактора неопределенности для прогнозирования перспектив развития отрасли и оценки возможностей и масштабов мер поддержки со стороны государства.
81th International Scientific Conference of the University of Latvia. Geodynamics and Geospatial Research. Conference Papers
Authors:   University of Latvia
Published: July 2023

The  conference “Geodynamics and Geospatial Research” organized by the  Institute of Geodesy and Geoinformatics of the University of Latvia addresses a wide range of scientific studies and is focused on the interdisciplinarity, versatility and possibilities of research in this wider context in the future to reach more significant discoveries, including business applications and innovations in solutions for commer-cial enterprises. The research presented at the conference is at different stages of its development and presents the achievements and the intended future. The publication is intended for researchers, students and research social partners as a source of current information and an invitation to join and support these studies.
EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA: ELEMENTOS AFRO- BRASILEIROS E INTERCULTURAIS NO CURRÍCULO INTEGRADO
Authors: Do Vale Carmina Viana de Paula , Maldaner Jair José , Rythowe Marcelo , Cavalcante Rivadávia Porto , Soares Khellen Cristina Pires Correia
Published: July 2023

Este artigo objetiva contribuir para o debate acadêmico, didático e pedagógico sobre a organização curricular de temas culturais afro-brasileiros no ensino médio integrado, com pretensão a uma formação geral do aluno. Será analisado o Projeto Pedagógico do curso técnico integrado de Meio Ambiente a respeito dos elementos/conteúdos afro-brasileiros organizados no projeto pedagógico de curso do ensino médio integrado. Para esse fim, faz-se o seguinte questionamento que orienta seu desenvolvimento: de que modo os elementos/conteúdos afro-brasileiros estão presentes e organizados no Projeto Pedagógico de cursos técnicos de nível médio de uma instituição federal do interior do estado do Maranhão? Nossa investigação será feita com base nos seguintes objetivos: (i) identificar e descrever a presença de elementos e temas culturais afro-brasileiros nas disciplinas curriculares do Projeto Pedagógico do Curso (PPC) de Meio ambiente; (ii) averiguar a inter-relação desses elementos e temas com o conteúdo das disciplinas da organização curricular. Para tanto, realizamos o estudo a partir de revisão bibliográfica relevante ao tema, bem como a análise documental que é o próprio projeto do curso. A pesquisa demonstra que apesar de constar na organização curricular do Projeto Pedagógico do Curso, as leis que estabelecem as diretrizes e bases da educação nacional, para incluir no currículo oficial da rede de ensino a obrigatoriedade da temática “História e Cultura Afro-Brasileira e Indígena, nos ementários das disciplinas, esses conteúdos são apresentados de forma periférica e não especifica sobre o que se vai abordar e nem como serão trabalhados.
Pengaruh Latihan Variasi Kelincahan Terhadap Kemampuan Dribbling Pada Pemain SSB
Authors: Prayoga Novian Ade , Ali Muhammad , Yanto Anggel Hardi
Published: July 2023

Tujuan penelitian ini untuk mengetahui pengaruh latihan variasi kelincahan terhadap kemampuan dribbling sepakbola pada pemain SSB Sidorukun Kabupaten Tebo Tahun 2022. Metode yang digunakan dalam penelitian ini menggunakan metode eksperimen. Populasi penelitian ini adalah seluruh pemain SSB Sidorukun Kabupaten Tebo Tahun 2022 yang berjumlah 70 anak. Penelitian ini menggunakan teknik purposive sampling dengan total sampel 15 pemain. Variabel penelitian ini yaitu latihan variasi kelincahan antara lain shuttle run, zig- zag run, three corner drill, 8 run. Metode pengumpulan data dilakukan menggunakan instrumen tes kemampuan dribbling. Desain yang digunakan dalam penelitian ini adalah one group pretest posttest design. Hasil analisis data menggunakan uji t diperoleh thitung lebih besar dari t tabel  yaitu 13,20> 2,145 dengan taraf signifikan 5%. Dengan demikian dapat dijelaskan bahwa terdapat peningkatan yang signifikan antara data sebelum dan sesudah diberikan perlakuan. Peningkatan rata-rata terlihat nyata karena terjadi peningkatan sebesar 2,60 dari 21,87 menjadi 19,27. Jika digambarkan dalam bentuk persentase peningkatan tersebut sebesar 13,49%. kesimpulan penelitian adalah terdapat pengaruh yang signifikan antara latihan variasi kelincahan terhadap kemampuan dribbling sepakbola pada pemain SSB Sidorukun Kabupaten Tebo.
Information ethics enforcement challenges in the real estate industry: A study of the emerging economy
Authors: Moropane Itumeleng Vanessa , Nenzhelele Tshilidzi Eric , Tshabalala Bonginkosi Daniel
Published: July 2023

The South African real estate industry contributes to job creation, economic development and poverty eradication (Estate Agency Affairs Board [EAAB], 2020). However, it is challenged by unethical, unregistered, and non-complying property practitioners firms (EAAB, 2018). Moreover, some firms have inefficient systems that fail to combat hacking and cybercrime (Jardine, 2015). Although firms have strategies in place, there are still instances of unethical behaviour. The accuracy of information is also a problem in the sector. The sector also encounters illegal access including breaking password-protected websites (Johnson, 2015). Hence, this research aimed to examine the extent to which firms enforce information ethics (IE) and to explore the challenges experienced by the firms in the Gauteng province when enforcing IE. The research was both qualitative and quantitative in nature and web-based questionnaires and in-depth interviews were used to collect primary data. The research found that property practitioners firms enforce IE to a great extent. However, they do so with challenges, namely, lack of trust from clients, stricter legislative requirements of keeping records, cybercrime and hacking, lack of physical and electronic storage of information, and clients’ information easily accessible at the Deeds Office. Property practitioners firms should strive to enforce IE to a greater extent while reducing and eliminating these challenges.
Trajectories of liver fibrosis and gene expression profiles in NAFLD associated with diabetes
Authors: Sako Saori , Takeshita Yumie , Takayama Hiroaki , Goto Hisanori , Nakano Yujiro , Ando Hitoshi , Tsujiguchi Hiromasa , Yamashita Tatsuya , Arai Kuniaki , Kaneko Shuichi , Nakamura Hiroyuki , Harada Kenichi , Honda Masao , Takamura Toshinari
Published: July 2023

Understanding the mechanisms linking steatosis to fibrosis is needed to establish a promising therapy against nonalcoholic fatty liver disease (NAFLD). This study aims to clarify clinical features and hepatic gene expression signatures that predict and contribute to liver fibrosis development during the long-term real-world histological course of NAFLD subjects with and without diabetes. A pathologist scored 342 serial liver biopsy samples from 118 subjects clinically diagnosed with NAFLD during a 3.8 years (SD 3.45, maximum 15 years) course of clinical treatment (UMIN; Clinical Trials Registry, no. UMIN000035231). At the initial biopsy, 26 subjects had simple fatty liver, and 92 had nonalcoholic steatohepatitis (NASH). In the trend analysis, the Fibrosis-4 index (P < 0.001) and its components at baseline predicted the future fibrosis progression. In the generalized linear mixed model, an increase in HbA1c, but not BMI, was significantly associated with fibrosis progression (0.17 [0.009–0.326]; P = 0.038) for NAFLD subjects with diabetes. In gene set enrichment analyses, the pathways involved in hepatocytes zone 3, central liver sinusoidal endothelial cell (LSEC), stellate cells, and plasma cells were coordinately altered in association with fibrosis progression and HbA1c elevation. Therefore, in NAFLD subjects with diabetes, HbA1c elevation is significantly associated with liver fibrosis progression, independent of weight gain, which may be a valuable therapeutic target to prevent the pathological progression of NASH. Gene expression profiles suggest that diabetes-induced hypoxia and oxidative stress injure LSEC injury in zone 3, which may mediate inflammation and stellate cell activation, leading to liver fibrosis. 
Lysine 117 residue is essential for the function of the hepatocyte nuclear factor 1α
Authors: Chu Yuan , Zhao Long , Liu Xian , Chen Hui , Zhao Chen , Chen Sicong , Xiang Shensi , Lu Jun , Wang Xiaofang , Wan Yue , Dong Diandian , Yao Songhui , Li Changyan , Yin Ronghua , Ren Guangming , Yang Xiaoming , Yu Miao
Published: July 2023

Hepatocyte nuclear factor 1α (HNF1α) plays essential roles in controlling development and metabolism, its mutations are clearly linked to the occurrence of maturity-onset diabetes of the young (MODY3) in humans. Lysine 117 (K117) to glutamic acid (E117) mutation in the HNF1α gene has been clinically associated with MODY3, but no functional data on this variant is available. Here, we addressed the role of lysine 117 in HNF1α function using a knock-in animal model and site-directed mutagenesis. HNF1α K117E homozygous mice exhibited dwarfism, hepatic dysfunction, renal Fanconi syndrome and progressive wasting syndrome. These phenotypes were very similar to those of mice with complete HNF1α deficiency, suggesting that K117 is critical to HNF1α functions. K117E homozygotes developed diabetes in the early postnatal period. The relative deficiency of serum insulin levels and the normal response to insulin treatment in homozygous mice were markedly similar to those in the MODY3 disorder in humans. Moreover, K117E heterozygous mutant causes age-dependent glucose intolerance which is similar with the pathogenesis of MODY3 as well. K117 mutants significantly reduced the overall transactivation and DNA binding capacity of HNF1α by disrupting dimerization. Collectively. our findings reveal a previously unappreciated role of POU domain of HNF1α in homodimerization, and also provide important clues for identifying the molecular basis of HNF1α related diseases such as MODY3.