bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors associated with change in moderate or severe symptoms of anxiety and depression in community-living adults and older adults during the COVID-19 pandemic
Authors: Vasiliadis Helen-Maria , Spagnolo Jessica , Bartram Mary , Fleury Marie-Josée , Gouin Jean-Philippe , Grenier Sébastien , Roberge Pasquale , Shen-Tu Grace , Vena Jennifer E. , Lamoureux-Lamarche Catherine , Wang JianLi
Published: December 2023

Objectives

Few are the longitudinal studies on the changes in moderate or severe symptoms of anxiety or depression (MSS-ANXDEP) from before to during the COVID-19 pandemic in Canada. The aim was to study the change in MSS-ANXDEP and associated sociodemographic, economic, psychosocial, health behaviour and lifestyle, and clinical factors.

Methods

The current sample includes 59,997 adults aged ≥ 35 years participating in the 2018 and 2020 health surveys of the 5 established cohorts of the Canadian Partnership for Tomorrow’s Health (CanPath). MSS-ANXDEP was based on a cutoff score ≥ 10 on the 7-item Generalized Anxiety Disorder Scale and Patient Health Questionnaire (PHQ-8). Change in MSS-ANXDEP was categorized as follows: no MSS-ANXDEP, remitted, incident, and persistent. Multinomial regressions were used to study MSS-ANXDEP as a function of sociodemographic, economic, psychosocial, health behaviours and lifestyle, and clinical factors.

Results

Sociodemographic and economic (i.e. age, gender, cohort, race/ethnicity, lower income, decreased in income, work status, being an essential worker), lifestyle and health behaviours (i.e. smoking, cannabis and alcohol use, drinking more alcohol), psychosocial (i.e. provide help to others, information and instrumental support, and change in relationships with friends, family, and partner) and clinical factors (i.e. lifetime mental disorder and multimorbidity) were associated with remitted, incident, and persistent MSS-ANXDEP.

Conclusion

Health and socio-economic factors were associated with changes in symptoms of anxiety and depression during the pandemic, further increasing inequities in mental health needs. Public health campaigns on the importance of healthy behaviours should continue and health policies should reduce economic and social barriers to integrated substance use and mental health care.
Assessment of orofacial functions in children using ‘off track’ mobile application: A cross-sectional study
Authors: Prajakta P Patwardhan , Amar N Katre
Published: December 2023

Introduction: Orofacial dysfunctions interfere with normal growth and development and may lead to multiple outcomes, including malocclusion. Assessment of Orofacial functions is thus critical in children. Methods: ‘Off Track’, a mobile-based app was used for orofacial functional assessment. The domains assessed were breathing, swallowing, chewing, speech, sleep, and others. The dysfunctions in each domain and the ‘Off Track’ score distribution were represented as frequency with percentages. Fisher's exact test was used to detect the difference between the age groups. Unadjusted odds were estimated to assess the association between feeding history and breathing dysfunction, feeding history and sleep dysfunction, and breathing dysfunction and sleep dysfunction. Result: The ‘Off Track’ scores 3, 4, 5, and 6 were recorded in 42.9%, 39.3%, 14.3% and 3.6% of the population, respectively. Most of the participants (89.29%) showed dysfunction in the breathing domain followed by swallowing (75%). The difference between the age groups was not significant (p > 0.05). Odd’s ratios estimated for feeding history of the child and, mouth breathing and sleep dysfunction were not statistically significant. Conclusion: Orofacial dysfunctions are widely prevalent in children and ‘Off Track’ may serve as a chairside user-friendly app-based screening tool to assess orofacial functions in children.
Analisis Makna Idiomatis Bahasa Melayu Batu Bara Pada Percakapan Masyarakat Desa Benteng
Authors: Dewi Rahma , Nisa Khairun
Published: December 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui makna idiomatis bahasa Melayu Batu Bara pada percakapan Masyarakat Desa Benteng Kecamatan Talawi Kabupaten Batu Bara. Metode yang digunakan dalam penelitian ini adalah metode kualitatif yang bersifat deskriptif (penggambaran). Pengumpulan data yang dilakukan menggunakan teknik observasi, teknik wawancara, teknik rekam catat, dan teknik dokumentasi. Idiom adalah perkataan atau kelompok kata yang khususnya untuk menyatakan suatu maksud dengan arti kiasan. Pada saat ini kurangnya pengetahuan generasi sekarang dan kurangnya keinginan untuk melestarikan bahasa daerah Suku Melayu di Kabupaten Batu Bara, mengenai makna idiomatis dalam sebuah percakapan dapat menyebabkan terjadinya sebuah kebodohan sepihak, yang mana para generasi sekarang tidak mengetahui makna dari sebuah idiom yang diungkapkan oleh para orang tua. Makna idiomatis yang terdapat dalam percakapan Masyarakat Desa Benteng, mengandung banyak makna idiomatis Bahasa Melayu Batu Bara Kecamatan Talawi Kabupaten  Batu Bara.Kata Kunci: bahasa Melayu; makna idiomatis; percakpan masyarakat Abstract: This study aims to determine the idiomatic meaning of Batu Bara Malay Language in the conversation of the Benteng Village Community, Talawi District, Batu Bara Regency. The method used in this research is a descriptive qualitative method (depiction). Data collection was carried out using observation techniques, interview techniques, note recording techniques, and documentation techniques. Idioms are words or groups of words specifically to express a meaning with a figurative meaning. At this time, the lack of knowledge of the current generation and the lack of desire to preserve the local language of the Malay Tribe in Batu Bara Regency, regarding the idiomatic meaning in a conversation can lead to a one-sided ignorance, where the current generation does not know the meaning of an idiom expressed by people. old. The idiomatic meaning contained in the conversation of the Benteng Village Community, contains many idiomatic meanings in Batu Bara Malay Language, Talawi District, Batu Bara Regency.Keywords: Malay language; idiomatic meaning; community conversation
Perubahan, Pergeseran, dan Pemertahanan Bahasa Sunda di Lingkungan Universitas Pendidikan Indonesia
Authors: Robiah Dini Fitriani Noor , Hernawan Hernawan
Published: December 2023

Abstrak: Penelitian ini dilatar belakangi oleh fenomena perubahan dan pergeseran berbahasa, yang tadinya menggunakan bahasa Daerah beralih ke bahasa Indonesia. Peristiwa ini sering ditemui di kalangan masyarakat khususnya mahasiswa. Subjek penelitian ini adalah mahasiswa UPI yang lahir di Jawa Barat. Penelitian ini bertujuan untuk mengetahui pola perubahan bahasa Sunda pada mahasiswa UPI ketika berinteraksi, pergeseran pemakaian bahasa Sunda pada mahasiswa UPI, dan langkah yang tepat untuk mempertahankan bahasa Daerah di kalangan mahasiswa UPI. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pendekatan kualitatif. Teknik yang digunakan adalah teknik pengumpulan data melalui penyebaran kuisioner. Hasil dari penelitian ini menunjukan perubahan dan pergeseran bahasa Sunda di kalangan mahasiswa UPI. Dengan persentase 32% memakai bahasa Sunda, 68% sisanya memakai bahasa Indonesia yang dicampur bahasa Sunda. Sehingga didapat upaya-upaya untuk mempertahankan bahasa Sunda dikalangan Mahasiswa UPI.  Kata Kunci: perubahan bahasa; pergeseran bahasa; pemertahanan bahasa. Abstract: This research is motivated by the phenomenon of language change and shifting, which had used local languages to switch to Indonesian. This event is often found in the community, especially students. The subjects of this study were UPI students who were born in West Java. This study aims to determine patterns of Sundanese language change in UPI students when interacting, shifting the use of Sundanese in UPI students, and appropriate steps to maintain regional languages among UPI students. The method used in this research is descriptive method with a qualitative approach. The technique used is the technique of collecting data through questionnaires. The results of this study indicate changes and shifts in Sundanese among UPI students. With a percentage of 32% using Sundanese, the remaining 68% using Indonesian mixed with Sundanese. In order to obtain efforts to maintain Sundanese among UPI students.Keywords: change of language; shift of language; retention of language.
Ketabahan Seorang Istri dan Nilai Keagamaan dalam Naskah “Siti Jaojah”
Authors: Ameliawati Sasti , Ruhaliah Ruhaliah , Nurjanah Nunuy
Published: December 2023

AbstrakPenelitian ini dilatarbelakangi oleh kurangnya kesadaran masyarakat terhadap naskah. Dewasa ini, naskah sudah jarang diketahui, tidak dibaca, bahkan sudah tidak dikenal oleh masyarakat. Penelitian ini bertujuan untuk mentransliterasikan dan mendeskripsikan isi naskah “Siti Jaojah” serta menganalisis nilai keagamaan yang terkandung di dalamnya. Sebelum itu, juga dilakukan analisis struktur formal dan naratif naskah. Metode yang digunakan adalah metode deskriptif-analisis dengan teknik wawancara, studi pustaka, dan dokumentasi. Sumber data yang digunakan dalam penelitian ini adalah naskah “Siti Jaojah”. Berdasarkan hasil penelitian, didapatkan beberapa hal seperti berikut: 1) isi naskah, 2) dari hasil analisis struktur formal, didapatkan kesalahan guru lagu dan guru wilangan. Jumlah kesalahan guru wilangan dari semua pupuh yang terdapat pada naskah “Siti Jaojah” adalah 26,8% (692 kesalahan) dari 2583 larik dan 2,75% kesalahan pada guru lagu (71 kesalahan), watek pupuh, serta terdapat 30 sasmita pupuh. Pada struktur naratif menggunakan alur campuran yang terdiri atas sembilan episode, terdapat lima motif cerita, dua belas tokoh, latar yang terdiri atas latar tempat, waktu, dan sosial, serta tema naskah mengenai perjalanan dan keagamaan, dan 3) nilai keagamaan yang terkandung dalam naskah ini adalah: akidah, syari’at, dan akhlak. Dari hasil kajian, dapat disimpulkan bahwa dalam naskah “Siti Jaojah” mengandung banyak kesalahan atau kekeliruan dalam penggunaan patokan pupuh. Untuk nilai keagamaannya, naskah ini menceritakan cara untuk menjadi istri shalihah yang tergambarkan dari watak tokoh utama, yaitu Nyi Jaojah.
Sikap Berbahasa Sunda Mojang Jajaka Kabupaten Bandung Sebagai Ikon 'Urang Sunda'
Authors: Anggraeni Shinta
Published: December 2023

Abstrak: Penelitian ini dilatarbelakangi oleh pentingnya kemampuan berbahasa Sunda para Mojang Jajaka yang merupakan duta budaya dan pariwisata sebagai ikon 'urang sunda'. Penelitian ini bertujuan untuk mengetahui sikap berbahasa sunda para Mojang Jajaka Kabupaten Bandung di lingkungan keluarga dan pendidikan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif pendekatan kualitatif, dengan teknik observasi dan angket. Instrumen penelitian ini adalah pedoman angket. Penelitian ini mendéskripsikan sikap berbahasa Sunda Mojang Jajaka Kabupaten Bandung di lingkungan keluarga dan pendidikan di Kabupaten Bandung  berdasarkan ciri-ciri sikap berbahasa yaitu kesetiaan berbahasa, kebanggaan berbahasa, dan kesadaran adanya norma berbahasa. Hasil penelitian menunjukkan sikap positif, meskipun dalam fenomena yang terjadi penggunaan bahasa sunda berdasarkan kesadaran adanya norma berbahasa masih belum optimal. Hal ini dikarenakan pengetahuan akan Tatakrama Bahasa Sunda yang masih terbilang rendah. Artinya Mojang Jajaka Kabupaten Bandung  bangga memiliki bahasa Sunda, tetapi kemampuan yang masih belum optimal menyebabkan Mojang Jajaka Kabupaten Bandung secara umum belum  menggunakan bahasa sunda dengan baik.
Hermeneutic Studies of Historical Romanticism of Pajajaran and Siliwangi in Mamaos Cianjuran
Authors: Zainhani Fadila Rahma
Published: December 2023

This study uses romantic hermeneutic studies to determine the historical value contained in Mamaos Cianjuran. Mamos Cianjuran about Pajajaran and Siliwangi is a literary work that contains high artistic and cultural value. By using the theory of Hermenautics, the essence of writing the work can be obtained.  The problems discussed in this study are studied through six methods, 1) place literary works as objects under study and position them as facts of ontology, 2) objectivize their structure, by analyzing the structural work of literature. 3) symbolization. 4) interpretation of symbols, associated with the process of creativity of literati in producing his work. 5) associating symbols with other disciplines to complement the interpretation. 6) the discovery of meaning or message that exists in the literary work. Based on the results of the study, Mamaos Cianjuran contains the author's fantasy about the heyday of Pajajaran and Siliwangi
Di Taman Larangan: Analisis Sruktur Lahir dan Struktur Batin
Authors: Sridaryanti Derizda
Published: December 2023

Penelitian ini dilatarbelakangi oleh kurangnya pemahaman masyarakat (pembaca awam) terhadap sajak. Oleh sebab itu, penelitian ini bertujuan untuk mengembangkan pengetahuan dalam memahami sajak dengan cara menganalisis struktur lahir dan struktur batinnya. Metode yang digunakan adalah metode deskriptif analitik. Teknik yang digunakan yaitu teknik studi pustaka dengan instrumen berupa kartu data. Sumber data dalam penelitian ini yaitu buku kumpulan sajak Di Taman Larangan karya Surachman RM. Hasil penelitian ini menunjukkan bahwa dalam kumpulan sajak tersebut terkandung struktur lahir sajak yang meliputi diksi, imaji, kata konkret, gaya bahasa, dan purwakanti. Diksi yang digunakan banyak yang berkaitan dengan alam dan lingkungan sekitar. Imaji yang dominan berupa imaji penglihatan. Kata konkret yang digunakan banyak menggunakan kata-kata yang erat hubungannnya dengan lingkungan sekitar. Gaya bahasa yang paling banyak yaitu gaya bahasa personifikasi. Persajakan atau purwakanti yang paling banyak yaitu purwakanti maduswara. Adapun struktur batin dalam kumpulan sajak tersebut meliputi tema, rasa, nada, dan amanat. Tema yang banyak muncul yaitu tentang perjalanan, rasa yang banyak digunakan yaitu rasa sedih, dan nada yang dominan berupa nada lugas atau menceritakan sesuatu kepada pembaca, serta amanat yang diperoleh merupakan amanat yang bisa dijadikan pembelajaran untuk hidup ke depan. Simpulannya, kumpulan sajak ini memiliki struktur lahir dan struktur batin yang lengkap sehingga dapat memperkaya pengalaman batin pembaca.
METHYLATION PATTERN OF THE RUNX3 GENE AND ITS IMPACT ON RESPONSE TO IMATINIB THERAPY IN CHRONIC MYELOID LEUKEMIA
Authors: Mahmud Alan , Mohamad Dlnya , Hamid Mohammad
Published: December 2023

BackgroundChronic Myelogenous Leukemia (CML) is a clonal stem cell disease with deregulated tyrosine kinase activity of BCR-ABL. DNA methylation in gene promoters influences disease development, therapeutic response, and clinical outcome in various diseases.
ObjectivesThis study aimed to investigate the methylation pattern in promoter regions of the runt-related transcription factor 3 (RUNX3) gene and its effect on the response to imatinib therapy, among CML patients.
Patients and MethodsBlood samples were collected from 100 participants from November 2020 to February 2022, in two groups 75 samples of CML patients and 25 samples of healthy controls, genomic DNA was extracted from the samples by using the salting-out method, then Isolated DNA was treated with sodium bisulfite. By Methylation-Sensitive High-Resolution Melting (MS-HRM), the samples were analyzed.
ResultsThe promoter sequence methylation level is significantly higher (P<0.05) in DNA samples from CML patients than in the control group, the methylation level in most of the healthy control samples 96% was detected between 0-24% while in CML patients was 16%, in 25-49%, RUNX3 methylation levels in Health individuals were 4%, moreover in CML patients were 24% also, in 50-100% of methylation level, health control was 0%, in CML patient showed 60%. According to methylation detection of RUNX3 among Imatinib resistance and good response, the results of IM resistance were detected between 0-40% was 15.21%, Furthermore, in good response was 79.31%. In other hand at 41-100% RUNX3 methylation levels in IM resistance was 84.78%, while a good response was recorded at 20.68%.
ConclusionThe study concluded that RUNX3 gene hypermethylation often occurs in CML patients. Additionally, there is a strong correlation between RUNX3 hypermethylation and poor imatinib respondents. We found that both IM resistance and CML patients have higher levels of RUNX3 gene hypermethylation. Moreover, research on a larger sample size is required to validate these findings, which may serve as possible indicators of disease progression and imatinib resistance.
Role of angiotensin II and neuroendocrine factors in immunological regulation in patients with coronary heart disease: prospective cross-sectional study
Authors: Parfenyuk Vladimir K. , Logatkina Anna V. , Bondar Stanislav S. , Terekhov Igor V. , Nikiforov Viktor S.
Published: December 2023

BACKGROUND: Among chronic noncommunicable diseases, cardiovascular diseases, particularly coronary heart disease (CHD), are the leading cause of death. The rennin-angiotensin-aldosterone system plays an important role in CHD development and progression; however, its role in the regulation of immunoneuroendocrine interactions requires further analysis.
OBJECTIVE: To study the relationship between angiotensin II (AT II) and molecular regulators of the activity of whole blood mononuclear cells (MNCs) in patients with angina pectoris.
MATERIALS AND METHODS: This cross-sectional study enrolled 65 patients with exertional angina aged 45–67 years, including 19 apparently healthy individuals. The levels of interleukins (ILs), transforming growth factor-β1 (TGF-β1), prostaglandin E2 (PG E2), serotonin, thyroid-stimulating hormone (TSH), and AT II in the blood serum were determined. In MNCs, the concentrations of protein kinases FAK, JNK, p38, and ERK, signal transducers, and activators of transcription (STAT 3, 5A, and 6) were determined.
RESULTS: In patients with coronary artery disease, the production of TGF-β1 increased by 7.2% (p=0.00001), AT II by 136.9% (p=0.0001), serotonin by 129.0% (p=0.00001), IL-18 by 92.5% (p=0.00001), TSH by 51.7% (p=0.0012), ERK protein kinase content by 86.4% (p=0.0001), JNK by 56.8% (p=0.0001), and FAK by 55.3% (p=0.00002). The levels of IL-15 also decreased by 38.1% (p=0.0001), PG E2 by 39.5% (p=0.0001), and STAT3 by 52.5% (p=0.0001).
CONCLUSION: The nature of the identified relationships among the analyzed factors allows us to consider AT II as a factor that ensures adaptive coupling of immune and neuroendocrine regulatory mechanisms in patients with coronary artery disease, contributing to a change in the balance between macrophages and T-helper types 1 and 2.
Tissue science and histology in the system of biomedical scientific and educational disciplines
Authors: Shevlyuk Nikolaj N. , Stadnikov Alexander A.
Published: December 2023

In this article, the authors analyze the role and significance of histology in biomedical scientific and educational disciplines (history, present condition, and controversial issues). This study discusses the formation and development of histology—the science of tissues—and the emergence of notions about tissues and tissue classification. When describing the microscopic structure of plant organs in 1671, the English botanist and physician N. Grew (1641–1712) used the term “tissue” for the first time. In the mid-19th century, German histologists R.A. Kölliker (1817–1905) and F. Leydig (1821–1908) established the present scientific classification of tissues. These authors classified tissues into four main groups: epithelium, connective tissue and blood, nervous tissue, and muscle tissue. Russian scientists A.A. Zavarzin and N.G. Khlopin made significant contributions to developing tissue classification and evolution problems. It is worth noting that the term “tissue,” which was initially interpreted as purely morphological, has gained physiological content; that is, the idea of “tissue” has become a morphofunctional concept. The idea of tissue stability during the ontogenesis stages of organisms is one of the significant paradigms of histology. Fabric variability is allowed within certain limits within the tissue group to which the fabric belongs. There is no compelling evidence of tissue transition from one tissue group to another. The first histology departments appeared in European higher educational institutions in the middle of the 19th century and Russian higher educational institutions in the late 1960s. As a scientific discipline, histology has not exhausted its capabilities; therefore, excluding histology from the nomenclature of scientific specialization is incorrect.
Post-injection necrotic phlegmon of the penis in a 13-year-old boy
Authors: Mohammad Bashir , Tsibin Anatolii A. , Degtyarev Pavel Yu. , Kruck Nadezhda N. , Sidorov Andrei D. , Trubnikov Elisei A. , Yakunov Alexandr N. , Porfirieva Irina L.
Published: December 2023

The practice of injecting various substances into the tissues of the penis in order to increase its size is found among adult men in different countries. An analysis of domestic and world literature revealed only one publication of a clinical case of treatment of a 16-year-old teenager with penile oleogranuloma. A 13-year-old boy was admitted to the pediatric surgical department with complaints of pain and severe swelling of the penis. According to the patient (found out later), these symptoms appeared 3 days after injecting 4 ml of Vaseline oil with a syringe under the skin of the penis. Swelling and hyperemia of the skin appeared, the next day the temperature rose to 40 °C, dizziness, nausea appeared, there were repeated vomiting and loose stools. The cause of the disease was established only after detailed questioning in the department. Local status: the penis is sharply increased in volume due to pronounced vitreous edema, mainly along the dorsal surface, the skin is hyperemic with dark areas and detachment of the epidermis. Diagnosis: “Necrotizing phlegmon of the penis, condition after injections of Vaseline oil”. After medical preparation, surgery was performed. Under endotracheal anesthesia, a 2 cm incision was made along the dorsal surface of the penis. A turbid liquid of 35–40 ml was released from the wound cavity, drainage was done with rubber drains. After the operation, antibacterial therapy and dressings with hydrophobic ointment were carried out. The general condition of the child returned to normal, the wound was cleaned, a defect measuring 5 × 3 × 0.2 cm was formed. After 2 weeks, plastic surgery was performed according to the Diettel method: the foreskin was cut to the area distal to the granulating wound, the outer and inner leaves of the foreskin were sharply separated, a graft was formed from the outer layer and fixed to the wound. The postoperative period was favorable, healing was by primary intention. The patient was discharged in satisfactory condition on the twenty-fourth day from hospitalization. When examined after 4 months, the patient has no complaints; on the dorsum of the penis there is a normotrophic scar measuring 2 × 3.5 cm, which does not interfere with skin mobility. The introduction of foreign bodies under the skin of the penis, accompanied by serious complications, began to be practiced among adolescents. Therefore, this case report will be of interest not only for pediatric surgeons and urologists, but also for doctors of other specialties who may be approached by patients with changes in the penile area, since a true history cannot always be ascertained.
Experimental modeling of necrotic enterocolitis: A review
Authors: Severinov Dmitriy A. , Lipatov Vyacheslav A. , Gavrilyuk Vassili P. , Ivanova Ekaterina A.
Published: December 2023

Neonatal necrotizing enterocolitis (NEC) is a multifactorial disease of unspecified etiology. The lack of data on etiological factors and the complexity of pathogenetic mechanisms determine the complexity of NEC modeling. The authors involved in the study of the pathogenesis of NEC and the development of current treatments seek to model in the experiment the conditions that occur in clinical practice. Thus, this study aimed to analyze the options for the experimental modeling of neonatal NECs described in the public domain. Thus, more than 50 relevant scientific publications in databases such as Google Scholar, PubMed, Scopus (publishers Elsevier), and eLibrary (from 2000 to 2022) were reviewed. This paper describes the most current methods of modeling NEC, including in vitro (using cells and cell cultures), in vivo (in laboratory animals such as mice, rats, rabbits, and pigs), and ex vivo (using cadaver material) experiments.
Comparative analysis of the results of multispiral computed tomography using color mapping and magnetic resonance imaging in the diagnosis of acute hematogenous osteomyelitis in children
Authors: Pozdnyakov Alexander V. , Svarich Vyacheslav G. , Lyurov Denis A.
Published: December 2023

BACKGROUND: Although acute hematogenous osteomyelitis is considered a fairly well-studied disease, several articles emphasize that the frequency of diagnostic errors remains quite high. The clinical presentation of acute hematogenous osteomyelitis largely depends on its reactivity and localization. The latter has features of the clinical course in children of different age groups. Osteomyelitis can be difficult to detect because of the variability and nonspecificity of symptoms and physical and laboratory parameters. Rapid diagnosis is crucial for successful disease outcomes because untimely treatment increases the number of complications. Therefore, visualization should be aimed at early diagnosis and, ultimately, successful treatment.
AIM: This study aimed to evaluate the informative value of magnetic resonance imaging and multispiral computed tomography (MSCT) in the diagnosis of the intramedullary phase of acute hematogenous osteomyelitis as its earliest stage.
MATERIALS AND METHODS: Thirty patients suspected with acute hematogenous osteomyelitis underwent magnetic resonance imaging and MSCT using color mapping techniques and X-ray density assessment. At the final stage of the diagnostic algorithm, osteotonometry was performed. The contents of the bone marrow canal were taken for microbiological and bacteriological studies.
RESULTS: In the intramedullary phase of acute hematogenous osteomyelitis, magnetic resonance imaging and MSCT revealed signs of bone marrow edema in 96% of the cases. The sensitivity of magnetic resonance imaging was 96%, the same as that of MSCT; however, the specificity was significantly lower than that of MSCT using the color mapping method and X-ray density assessment, which was 67% and 83%, respectively (p 0.05).
DISCUSSION: In recent years, the role of computed tomography in the diagnosis of acute hematogenous osteomyelitis has received considerable recognition in pediatric surgical practice, and MSCT with color mapping and X-ray density assessment in the diagnosis of acute hematogenous osteomyelitis in children has been used relatively recently. Simultaneously, many researchers have reported the high informativeness of MSCT in the diagnosis of acute hematogenous osteomyelitis.
CONCLUSIONS: The intramedullary phase of acute hematogenous osteomyelitis according to magnetic resonance imaging and MSCT indicates bone marrow edema as its earliest stage. According to the data of the present study, MSCT using color mapping and X-ray density assessment has high specificity and can be used with MRI as the main method for diagnosing the intramedullary phase of acute hematogenous osteomyelitis.
Representasi Perempuan Berdaya pada Akun Instagram @rachelvennya
Authors: Husna Asmaul , Fahrimal Yuhdi
Published: December 2023

Era digital membuka peluang bagi perempuan bukan hanya untuk merepresentasikan eksistensi diri, tetapi dapat dimanfaatkan bagi peningkatan kapasitas diri untuk lebih berdaya secara pendidikan dan ekonomi tanpa harus meninggalkan peran mereka dalam keluarga. Tujuan penelitian ini adalah untuk menganalisis dan menjelaskan representasi diri perempuan berdaya di era digital khususnya di media sosial. Metode penelitian yang digunakan adalah analisis konten kualitatif dengan objek kajian akun Instagram @RachelVennya. Berdasarkan hasil penelurusan, koding, dan analisis data ditemukan bahwa Rachel Vennya merepresentasikan diri sebagai pesohor Instagram dan pengusaha perempuan yang tetap memprioritaskan kehidupan domestiknya di keluarga. Bentuk-bentuk representasi dirinya adalah berdikari secara ekonomi, pentingnya pendidikan bagi perempuan, mengutamakan keluarga, perempuan harus mampu memimpin, dan perempuan dapat berekspresi. Penelitian ini menyimpulkan bahwa Rachel Vennya adalah sebuah bukti bahwa perempuan mampu merepresentasikan diri mereka sebagai sosok yang tidak hanya terampil di area domestik, tetapi juga berpeluang menjadi inspirator dan pemimpin di era digital.
Clinical characteristics and laboratory profile of symptomatic COVID-19 patients from a tertiary Bangalore rural hospital: the lessons learnt
Authors: Rameshkumar Bharath Raj , Kumar Manoj , Shetty Bipin , Kannan Kanakaraj , Rameshkumar Karuna
Published: December 2023

Background: Aim of study was to analyse clinical and laboratory features and outcome of COVID-19 patients admitted in second wave of pandemic (April1 to May 31, 2021) (SW) and compare with covid 19 patients in third wave (TW).
Methods: COVID-19 positivity were confirmed in both SW and TW. Demographic features, symptoms and duration were recorded. X ray chest was done at the time of admission and for monitoring.  Complete blood count, C reactive protein, renal function tests, liver function tests, LDH and D dimer levels were done. The positive patients were categorized as mild, moderate and severe based on the clinical, imaging and laboratory features.
Results: Among 297 patients screened, 171 patients were diagnosed as positive (57.5%). 107 patients were admitted (62.5%). (M:F ratio - 1.74:1). The most common symptoms for hospitalization were fever, cough and shortness of breath. Though 38 patients had neutrophilia, only 16 of them presented with high NLR ratio. Consolidation on chest X-ray was present in all patients but the degree varied. 38 patients required ICU admission and oxygen support. 18 patients succumbed to disease. Among 140 patients (TW) (December 1 to January 31 2022, 69 (43.1%) were positive. Only 12 patients required hospitalisation. The only symptom was high fever. The NLR ratio ranged from 1-6 and never went beyond 6. All patients were discharged after 2-3 days.
Conclusions: The demographic features, co morbidities, presenting symptom of fever and X ray findings were similar in both waves. But the NLR ratio was never beyond 6 in TW. This was probably due to early reporting and vaccination status of the population and less virulent strain of the virus in TW. The present study confirmed that raised NLR and low levels of oxygen saturation at the time of admission are important predictors of disease severity.
Successful Treatment of Angiolymphoid Hyperplasia with Eosinophilia Associated with Scalp Demodicosis Using Cryotherapy and Topical Metronidazole
Authors: Al Kharusi Salma T , Al Lamki Aya A , Al Rajaibi Raqiya M , Al Ajmi Zakiya I
Published: December 2023

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign, vasoproliferative tumour. We report a 25-year-old female patient who reported in 2021 to the dermatology clinic, with multiple, grouped, erythematous dome-shaped papules and nodules of 6 months duration on the left temporo-occipital region. Biopsy findings were consistent with a diagnosis of ALHE with evidence of Demodex mite infestation in the sebaceous ducts. The patient demonstrated significant improvement following 7 weeks of treatment with multiple cryotherapy sessions and topical application of metronidazole gel. This case suggests that scalp demodicosis may represent a novel trigger for the development of ALHE.
Keywords: Angiolymphoid Hyperplasia with Eosinophilia; Mite; Infestation; Scalp; Kimura disease; Cryosurgery; Metronidazole; Case Report.
Coexistence of Pulmonary Thromboembolism, Pulmonary Tuberculosis and Granulomatosis with Polyangiitis
Authors: Pavirala Sai T , Khurana Alkesh , Kadian Kirti , Goyal Abhishek
Published: December 2023

Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease with multi‐system involvement. It involves the upper respiratory tract, lungs and kidneys. A 36-year-old female patient presented with complaints of low-grade fever, dry cough and loss of appetite initially followed by dyspnea, purpuric skin lesions, right lower limb swelling with pain and redness. Her chest radiograph revealed right upper lobe cavitary lesion with consolidation in right lower lobe. Mycobacterium tuberculosis was detected in sputum and Broncho alveolar lavage (BAL) via Cartridge based nucleic acid amplification assay (CB-NAAT). Later, Computed Tomography Pulmonary Angiography (CTPA) revealed bilateral pulmonary artery thromboembolism. Furthermore, her C-ANCA was positive, serum creatinine was rising, urine microscopy had red cell casts and lower limb venous doppler revealed DVT. Histopathological examination of the skin lesion revealed vasculitis. Based on the above findings, diagnosis of GPA was comfortably made. Patient improved with pulse steroids, cyclophosphamide, anticoagulants and anti-tuberculous therapy (ATT).
Keywords: Granulomatosis with polyangiitis (GPA), Pulmonary Tuberculosis, Pulmonary thrombo-embolism, deep venous thrombosis, vasculitis, c-ANCA.
Veganism and hypercoagulable state - hyperhomocysteinemia presenting as pulmonary thrombo-embolism in a vegetarian living at high altitude
Authors: Vaid Aarti , Behera Ashish , Sharma Navneet
Published: December 2023

Hyperhomocysteinemia as a hypercoagulable state has been debatable, but when associated with other high-risk factors like severe vitamin B12 and folate deficiency, smoking, high altitude, and antiphospholipid syndrome can present with thromboembolism. Vegans are at high risk of severe B12 deficiency as the primary source is animal products. Right now, the total number of vegans, vegetarians, and all related categories, is close to 14 per cent of the world population. We here present a young vegan with severe B12 deficiency presenting with sub-massive thromboembolism.
DEVELOPMENT OF CANVA LEARNING MEDIA IN INCREASING STUDENT SELF-EFFICACY AT MI AL ADNANI JOMBANG /تطوير الوسيلة التعليمية بتطبيفات "كنفا" في تنمية الكفاءة الذاتية لدي الطلاب في المدرسة الإبتدائية العدناني جومبانج
Authors: Qomariyah Lailatul , Mulloh Tamim , Fadhilah Lailatul
Published: December 2023

The learning media is the importance in teaching the Arabic language. This study aims to find out how to develop this media and its feasibility in increasing the student's self-efficacy. This study used a three-stage developmental approach, which is preliminary studies, development, and product testing with a questionnaire and a measure of self-efficacy. The method for analyzing the data used is the data collected and sorted into quantitative and qualitative data were converted into qualitative data on likert scale Based on the results of the research analysis, it is known that the use of the educational method "Canva" on the self-efficacy of students in the fourth grade in the Adnani- Elementary School is a value in education to add insight into the delivery of materials related to self-efficacy for primary students. The contribution of this research to the improvement of media is expected Learning to implement Arabic learning more effectively.
Öffentliche Kommunikation und Rechtsextremismus
Authors: Czyżewski Marek
Published: December 2023

Diese Arbeit hat zwei Schwerpunkte. Der eine bezieht sich auf die Prozesse in der öffentlichen, massenmedial vermittelten Kommunikation und beschäftigt sich vor allem mit Auseinandersetzungen im öffentlichen Diskurs – unabhängig von deren thematischer Fokussierung – und mit der Rolle der symbolischen Eliten. Der andere Schwerpunkt betrifft speziell öffentliche Konstruktionen des Rechtsextremismus sowie öffentliche Auseinandersetzungen der symbolischen Eliten mit dem Rechtsextremismus. Vorwiegend wird der Zeitraum der besonderen Zuspitzung rechtsextremer Gewalttätigkeit in Deutschland zwischen August 1992 und Januar 1993 – d.h., die Diskursentfaltung über diese Zuspitzung – untersucht. So werden hier öffentliche Debatten und Diskussionen über den Rechtsextremismus vor dem Hintergrund allgemeiner Eigenschaften und Tendenzen in der öffentlichen Kommunikation untersucht. Der Vorrang wird der analytischen und kritischen Betrachtung der allgemeinen Problematik öffentlicher Kommunikation gegeben. Aus vielen Gründen stellen die im öffentlichen Diskurs der symbolischen Eliten ausgetragenen Auseinandersetzungen mit dem Rechtsextremismus ein besonders aufschlussreiches Beobachtungsfeld in Hinblick auf allgemeine Eigenschaften, Tendenzen und Defizite der öffentlichen Kommunikation dar.
Managing the Demographic Development of Wastelands: The Historical Experience of Manchuria and Hokkaido at the Turn of the XIX-XX Centuries
Authors: Tkachev Sergey , Tkacheva Natalia
Published: December 2023

Mankind has developed many methods of settlement. Most of them have only informative value today. For practical purposes, we can be interested only in recent historical cases characterized, on the one hand, by mass scale and, on the other hand, by the increasing value of human life. In this article we will consider two such cases that took place at the end of the 19th and beginning of the 20th centuries in Northeast Asia: Manchuria and Hokkaido. By this time, the region was becoming a focus of political interests of the powers; to a large extent, the world’s attention began to shift to the events taking place here because of the gradually opening up of planetary-level economic potential. Wars and uprisings are breaking out here, and in parallel, migrants are actively flocking here. What were the goals of this movement? How was it controlled? How was it stimulated? What did these processes have in common and what distinguished them from each other? We will try to answer these questions in this article.
El proceso evolutivo de la humanidad a través de Psilocybe
Authors: Rayas Serrano Laura , González Romero Osiris , Romero Bautista Leticia
Published: December 2023

En las últimas dos décadas se han realizado diversas investigaciones para dilucidar los efectos terapéuticos de la psilocibina en el cuerpo y la mente de los seres humanos. Uno de los propósitos de este artículo es mostrar que no existe una oposición excluyente entre ciencia y espiritualidad. Para ello es importante reflexionar de manera crítica sobre los marcos conceptuales utilizados (psicodélicos, alucinógenos, enteógenos, neurotrópicos, entre otros), pero también sobre el papel que han tenido los compuestos psicoactivos involucrados en el proceso evolutivo, en este caso los hongos psilocibios. La presente investigación tiene como objetivo informar, en base a un análisis bibliográfico, acerca del papel que han tenido los hongos Psilocybe spp. en la evolución de la humanidad, así como realizar un análisis crítico de sus usos culturales. Uno de los tópicos específicos es examinar el papel que pudieron tener los usos rituales y terapeúticos de hongos psilocibios en el desarrollo del lenguaje. Por ejemplo, la importancia cultural presente en los cantos, plegarias y conjuros se expresa en el uso ritual y/o ceremonial del lenguaje, el cual es visto como un medio para entrar en contacto con los ancestros y entidades sagradas. Esta investigación pretende argumentar que el consumo de hongos psilocibios pudo contribuir a “expandir” la mente de nuestros antepasados ejerciendo una presión selectiva significativa sobre la evolución del pensamiento humano. Por último se explicarán algunos de los potenciales terapeúticos que tiene la psilocibina para atender diversos trastornos mentales mediante rituales, psicoterapias, tratamientos psiquiátricos, entre otros.
Tecnologias digitais e reorganização da produção internacional
Authors: Introini Marcelo , Marcato Marília , Sarti Fernando
Published: December 2023

A digitalização tem potencial de provocar transformações na organização da produção internacional e no escopo e extensão das cadeias globais e regionais de valor (CGVs), com efeitos sobre as possibilidades de inserção dos países em desenvolvimento. A contribuição deste artigo é analisar potenciais impactos da digitalização sobre as CGVs, valendo-se de uma discussão sobre a natureza e a evolução das tecnologias sob a perspectiva evolucionária. Ao sinalizar como a natureza das tecnologias digitais pode influenciar as estruturas de governança das CGVs, o artigo aponta tendências multifacetadas e, por vezes, de direções contrárias, entre elas o aumento da concentração de valor gerado nos países desenvolvidos e a ampliação das dificuldades de inserção dos países em desenvolvimento, sobretudo daqueles especializados em atividades intensivas em mão de obra e sem capacitações para adoção de tecnologias digitais.
Delayed union of a pediatric lunate fracture in the United Kingdom: a case report and a review of current concepts of non-scaphoid pediatric carpal fractures
Authors: Davis Timothy P. , Headon Elizabeth , Morgan Rebecca , Simpson Ashley I.
Published: December 2023

Pediatric carpal fractures are rare and often difficult to detect. This paper reviews the current literature on pediatric non-scaphoid carpal fractures, with a case report of a lunate fracture associated with a distal radius and ulnar styloid fracture, managed nonoperatively in a 12-year-old boy. There is lack of consensus regarding the management of these fractures due to the low number of reported cases. A frequent lack of long-term follow-up limits our understanding of the outcomes, but good outcomes have been reported for both nonoperative and operative management. This case report brings attention to the current time period for the definition of delayed union in pediatric carpal fractures, and emphasizes the need for prolonged follow-up for the detection of delayed complications leading to functional impairment.
A method of bedside urethrography before catheterization in pelvic trauma in Korea: a case report
Authors: Lee Hojun , Jeong Sung Yub , Hwang Kun
Published: December 2023

We introduce a convenient method of urethrography before catheterization for patients with pelvic trauma that can be used in a resuscitation area. A 10-mL syringe without a needle was used. X-ray contrast medium (Iohexol, 300 mg I/mL) was administered through the urethral orifice using a 10-mL syringe without needle and a simple pelvic anteroposterior film was taken (70 kilovolt [peak], 50 mAs). A 36-year-old soldier with a saddle injury from a gun barrel was taken to a trauma center. He had a pelvic fracture and complained of hematuria. Bedside urethrography above described was performed. The anterior urethra showed nonspecific findings, but dye leaked from the posterior urethra. Bedside Foley catheter insertion was attempted, but the catheter could not be advanced past the membranous urethra. Thereafter, suprapubic catheterization was performed. On the day of the injury, iliac artery embolization was carried out. The dislocated sacroiliac joint was also treated using open reduction and internal fixation. On hospital day 7, guidewire Foley insertion was performed. This bedside urethrography technique is simple and useful for pelvic fractures in which urethral injury is suspected.
Penerimaan Diri Perempuan Korban Sekstorsi: Sebuah Tinjauan Literatur Naratif
Authors: Adhita Putri Ariani  , Herdiana Ike
Published: December 2023

Sekstorsi adalah istilah yang belakangan ini muncul dan berasal dari kata “sex” dan “extortion”. Sekstorsi dapat berupa penyebaran gambar seksual para korban sebagai ancaman untuk mendapatkan uang maupun barang berharga lainnya. Para korban sekstorsi mengalami pengalaman yang buruk sehingga mendatangkan trauma yang memerlukan proses penerimaan diri yang cukup panjang mengenai keadaan yang mereka alami. Tinjauan literatur ini diperoleh dari artikel yang berkaitan dengan permasalahan tersebut dan bertujuan untuk menganalisis proses penerimaan diri para korban sekstorsi pasca kejadian serta menganalisis faktor-faktor yang terlibat dalam proses penerimaan diri para korban. Hasil review dari beberapa literatur menunjukkan bahwa proses penerimaan diri para korban sekstorsi pasca kejadian memiliki beberapa tahapan dimulai dari fase penyangkalan, evaluasi diri, mawas diri dan penerimaan diri. Faktor-faktor yang memengaruhi proses penerimaan diri dibedakan menjadi dua yaitu faktor internal berupa pemahaman diri, kesadaran diri dan kemauan diri untuk mengubah keadaan; serta faktor eksternal, yaitu lingkungan sekitar korban.
Pengaruh Self-Compassion terhadap Compassion Fatigue pada Perawat Hemodialisis
Authors: Prayogo Maulana , Ariana Atika Dian
Published: December 2023

Compassion fatigue adalah kelelahan yang terjadi pada perawat sebagai respon stress yang diakibatkan dari paparan terhadap sakit dan trauma pasien. Karakteristik pekerjaan perawat hemodialisis menempatkan mereka di posisi yang berisiko terhadap compassion fatigue. Tujuan penelitian ini adalah untuk melihat apakah self-compassion berpengaruh terhadap compassion fatigue pada perawat hemodialisis. Penelitian ini dilakuakan pada 73 perawat hemodialisis. Alat ukur yang digunakan adalah Self-Compassion Scale oleh Neff dan Professional Quality of Life Scale versi 5 oleh Stamm. Data dianalisis menggunakan analisis regresi linear sederhana terhadap dua aspek compassion fatigue: burnout dan secondary traumatic stress. Hasil penelitian menunjukkan bahwa self-compassion memiliki pengaruh negatif dan signifikan terhadap burnout dan secondary traumatic stress. Artinya, self-compassion yang tinggi dapat memprediksi burnout dan secondary traumatic stress yang rendah pada perawat hemodialisis.
Hubungan Peer Influence terhadap Munculnya Perilaku Non-Suicidal Self-Injury pada Remaja
Authors: Mailaffayza Qorinatu , Arbi Dian Kartika Amelia
Published: December 2023

Penelitian ini bertujuan untuk mengetahui apakah ada hubungan antara peer influence dengan munculnya perilaku non-suicidal self-injury pada remaja. Pengaruh teman sebaya mengacu pada pengaruh yang dimiliki oleh teman sebaya terhadap perilaku, sikap, dan keputusan seorang individu. NSSI mencakup lima kriteria, yaitu perilaku tersebut melibatkan cedera yang disengaja pada jaringan tubuh sendiri (misalnya memotong, membakar, mencakar, memukul diri sendiri), dimana perilaku tersebut tidak dilakukan dengan niat bunuh diri. Penelitian ini menggunakan kuantitatif dengan metode survei. Analisis data pada penelitian ini menggunakan teknik uji korelasi. Hasilnya menunjukkan adanya hubungan positif yang signifikan (r=0,276; p=0,005<0,05) sehingga apabila terjadi peningkatan pada resistensi pengaruh teman sebaya maka perilaku NSSI juga meningkat.