bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Report: ISPD Gene Mutation Leads to Dystroglycanopathies: Genotypic Phenotype Analysis and Treatment Exploration
Authors: Yang Haiyan , Cai Fang , Liao Hongmei , Gan Siyi , Xiao Ting , Wu Liwen
Published: August 2021

ISPD gene mutation-related diseases have high clinical and genetic heterogeneity, and no studies have yet reported any effective treatments. We describe six patients with dystroglycanopathies caused by ISPD gene mutations and analyze their genotypes and phenotypes to explore possible effective treatments. Our results confirm that the phenotype of limb-girdle muscular dystrophies can be easily misdiagnosed as Duchenne muscular dystrophy and that exon deletions of ISPD gene are relatively common. Moreover, low-dose prednisone therapy can improve patients' exercise ability and prolong survival and may be a promising new avenue for ISPD therapy.
Rejuvenation of Helicobacter pylori–Associated Atrophic Gastritis Through Concerted Actions of Placenta-Derived Mesenchymal Stem Cells Prevented Gastric Cancer
Authors: Park Jong Min , Han Young Min , Hahm Ki Baik
Published: August 2021

Chronic Helicobacter pylori infection causes gastric cancer via the progression of precancerous chronic atrophic gastritis (CAG). Therefore, repairing gastric atrophy could be a useful strategy in preventing H. pylori–associated gastric carcinogenesis. Although eradication of the bacterial pathogen offers one solution to this association, this study was designed to evaluate an alternative approach using mesenchymal stem cells to treat CAG and prevent carcinogenesis. Here, we used human placenta-derived mesenchymal stem cells (PD-MSCs) and their conditioned medium (CM) to treat H. pylori–associated CAG in a mice/cell model to explore their therapeutic effects and elucidate their molecular mechanisms. We compared the changes in the fecal microbiomes in response to PD-MSC treatments, and chronic H. pylori–infected mice were given ten treatments with PD-MSCs before being sacrificed for end point assays at around 36 weeks of age. These animals presented with significant reductions in the mean body weights of the control group, which were eradicated following PD-MSC treatment (p < 0.01). Significant changes in various pathological parameters including inflammation, gastric atrophy, erosions/ulcers, and dysplastic changes were noted in the control group (p < 0.01), but these were all significantly reduced in the PD-MSC/CM-treated groups. Lgr5+, Ki-67, H+/K+-ATPase, and Musashi-1 expressions were all significantly increased in the treated animals, while inflammatory mediators, MMP, and apoptotic executors were significantly decreased in the PD-MSC group compared to the control group (p < 0.001). Our model showed that H. pylori–initiated, high-salt diet–promoted gastric atrophic gastritis resulted in significant changes in the fecal microbiome at the phylum/genus level and that PD-MSC/CM interventions facilitated a return to more normal microbial communities. In conclusion, administration of PD-MSCs or their conditioned medium may present a novel rejuvenating agent in preventing the progression of H. pylori–associated premalignant lesions.
Interventions for Preventing Cardiotoxicity in Breast Cancer Patients Receiving Trastuzumab: A Systemic Review and Bayesian Network Meta-Analysis
Authors: Li Xinyi , Wu Ziyang , Du Xin , Wu Yibo , Xie Xiaohui , Shi Luwen
Published: August 2021

Background: Trastuzumab is associated with the risk of cardiotoxicity. Here, we aim to explore interventions for preventing trastuzumab-related cardiotoxic effects in breast cancer patients.

Methods: A systematic review was performed including trials of breast cancer patients with intervention to prevent cardiotoxicity of trastuzumab. Trials were searched through databases including PubMed, Embase, and Cochrane Library.

Results: Eight RCTs were included. Five trials reported the outcomes of short-duration interventions, including 6-month and 9-week durations, and only 9-week treatment has a significant difference from the 12-month group (OR 0.38; 95% CI 0.18–0.83) using cardiotoxicity as the outcome. However, 6-month treatment turned out to yield less occurrence of trastuzumab discontinuation (OR 0.32; 95% CI 0.24–0.42). Three trials reported interventions of cardioprotective drugs, and there is no significant difference shown in any cardioprotective group compared with placebo (cardiotoxicity outcome: angiotensin-converting enzyme inhibitor: OR 0.48; 95% CI 0.057–2.3; angiotensin receptor blocker: OR 1.3; 95% CI 0.12–14; β-blocker: OR 0.48; 95% CI 0.057–2.3; trastuzumab interruption outcome: angiotensin-converting enzyme inhibitor: OR 0.45; 95% CI 0.12–1.3; angiotensin receptor blocker: OR 0.87; 95% CI 0.15–4.8; β-blocker: OR 0.41; 95% CI 0.11–1.2).

Conclusion: Only the 9-week group has a significant difference from the 12-month group using cardiotoxicity as the outcome. And 6-month treatment turned out to yield less occurrence of trastuzumab discontinuation. The use of cardioprotective drugs failed to prevent trastuzumab-related cardiotoxic effects in breast cancer patients.
Construction of C1 Rational Bi-Quartic Spline With Positivity-Preserving Interpolation: Numerical Results and Analysis
Authors: Abdul Karim Samsul Ariffin , Saaban Azizan , Nguyen Van Thien
Published: August 2021

From the observed datasets, we should be able to produce curve surfaces that have the same characteristics as the original datasets. For instance, if the given data are positive, then the resulting curve or surface must be positive on entire given intervals, i.e., everywhere. In this study, a new partial blended rational bi-quartic spline with C1 continuity is constructed through the partially blended scheme. This rational spline is defined on four corners of the rectangular meshes. The sufficient condition for the positivity of rational bi-quartic spline is derived on four boundary curve networks. There are eight free parameters that can be used for shape modification. The first-order partial derivatives are estimated by using numerical techniques. We also show that the proposed scheme is local quadratic reproducing such that it can exactly reproduce the quadratic surface. We test the proposed scheme to interpolate various types of positive surface data. Based on statistical indicators such as the root mean square error (RMSE) and coefficient of determination (R2), we found that the proposed scheme is on par with some established schemes. In fact, it requires less CPU times (in seconds) to generate the interpolating surface on rectangular meshes. Furthermore, by combining the statistical indicators’ result and graphically visualizing the test functions, the proposed method has the capability to reconstruct very comparable smoothing interpolating positive surfaces compared to some existing schemes. This finding is significant in producing a better interpolating surface for computer graphics applications since the proposed scheme has a smaller error compared with existing schemes.
Anchoring Groups Determine Conductance, Thermopower and Thermoelectric Figure of Merit of an Organic Molecular Junction
Authors: Ramezani Akbarabadi Saeideh , Madadi Asl Mojtaba
Published: August 2021

Transport properties of molecular junctions are prone to chemical or conformational modifications. Perturbation of the molecule-electrode coupling with anchoring groups or functionalization of the molecule with side groups is a well-characterized method to modulate the thermoelectric properties of molecular junctions. In this study, we used wide-band approximation combined with the non-equilibrium Green’s function (NEGF) formalism to inspect conductance, thermopower and figure of merit of an anthracene molecule coupled to gold (Au) electrodes. To provide a comparative study, three different anchoring groups were used, i.e., thiol, isocyanide and cyanide. The molecule was then perturbed with the amine side group in two positions to explore the interplay between anchoring groups and the side group. We showed that the introduction of side group alters transmission probability near the Fermi energy where transmission peaks are shifted relative to the Fermi level compared to the unperturbed molecule (i.e., without side group), ultimately leading to modified electrical and thermoelectric properties. The greatest value of electrical conductance was achieved when the side-group-perturbed molecule was anchored with isocyanide, whereas the thiol-terminated molecule perturbed with the side group yielded the greatest value of thermal conductance. We found that the Wiedemann-Franz law is violated in the Au-anthracene-Au device. Furthermore, the highest thermopower and figure of merit were attained in the cyanide-terminated perturbed molecule. Our results indicate that charge donating/accepting character of the anchoring group and its interplay with the side group position can modify temperature dependency of conductance, thermopower and figure of merit which is in agreement with experimental findings in organic molecular junctions. Such modifications may potentially contribute to the understanding of emerging conductance-based memory devices designed to mimic the behavior of brain-like synapses.
Differences in Physiological and Perceptual Responses to High Intensity Interval Exercise Between Arm and Leg Cycling
Authors: Astorino Todd A. , Emma Danielle
Published: August 2021

This study compared changes in oxygen uptake (VO2), heart rate (HR), blood lactate concentration (BLa), affective valence, and rating of perceived exertion (RPE) between sessions of high intensity interval exercise (HIIE) performed on the arm (ACE) and leg cycle ergometer (LCE). Twenty three active and non-obese men and women (age and BMI=24.7±5.8year and 24.8±3.4kg/m2) initially underwent graded exercise testing to determine VO2max and peak power output (PPO) on both ergometers. Subsequently on two separate days, they performed 10 1min intervals of ACE or LCE at 75 %PPO separated by 1min of active recovery at 10 %PPO. Gas exchange data, HR, and perceptual responses were obtained continuously and blood samples were acquired pre- and post-exercise to assess the change in BLa. VO2max and PPO on the LCE were significantly higher (p<0.001) than ACE (37.2±6.3 vs. 26.3±6.6ml/kg/min and 259.0±48.0 vs. 120.0±48.1W). Mean VO2 (1.7±0.3 vs. 1.1±0.3L/min, d=2.3) and HR (149±14 vs. 131±17 b/min, d=2.1) were higher (p<0.001) in response to LCE vs. ACE as was BLa (7.6±2.6 vs. 5.3±2.5mM, d=2.3), yet there was no difference (p=0.12) in peak VO2 or HR. Leg cycling elicited higher relative HR compared to ACE (81±5 vs. 75±7 %HRmax, p=0.01), although, there was no difference in relative VO2 (63±6 vs. 60±8 %VO2max, p=0.09) between modes. Affective valence was lower during LCE vs. ACE (p=0.003), although no differences in enjoyment (p=0.68) or RPE (p=0.59) were demonstrated. Overall, HIIE performed on the cycle ergometer elicits higher relative heart rate and blood lactate concentration and a more aversive affective valence, making these modes not interchangeable in terms of the acute physiological and perceptual response to interval based exercise.
Sex Differences in Drug-Induced Arrhythmogenesis
Authors: Peirlinck Mathias , Sahli Costabal Francisco , Kuhl Ellen
Published: August 2021

The electrical activity in the heart varies significantly between men and women and results in a sex-specific response to drugs. Recent evidence suggests that women are more than twice as likely as men to develop drug-induced arrhythmia with potentially fatal consequences. Yet, the sex-specific differences in drug-induced arrhythmogenesis remain poorly understood. Here we integrate multiscale modeling and machine learning to gain mechanistic insight into the sex-specific origin of drug-induced cardiac arrhythmia at differing drug concentrations. To quantify critical drug concentrations in male and female hearts, we identify the most important ion channels that trigger male and female arrhythmogenesis, and create and train a sex-specific multi-fidelity arrhythmogenic risk classifier. Our study reveals that sex differences in ion channel activity, tissue conductivity, and heart dimensions trigger longer QT-intervals in women than in men. We quantify the critical drug concentration for dofetilide, a high risk drug, to be seven times lower for women than for men. Our results emphasize the importance of including sex as an independent biological variable in risk assessment during drug development. Acknowledging and understanding sex differences in drug safety evaluation is critical when developing novel therapeutic treatments on a personalized basis. The general trends of this study have significant implications on the development of safe and efficacious new drugs and the prescription of existing drugs in combination with other drugs.
Understanding the Role of Gibberellic Acid and Paclobutrazol in Terminal Heat Stress Tolerance in Wheat
Authors: Nagar Shivani , Singh V. P. , Arora Ajay , Dhakar Rajkumar , Singh Neera , Singh G. P. , Meena Shashi , Kumar Sudhir , Shiv Ramakrishnan R.
Published: August 2021

Understanding the physiological mechanism of tolerance under stress conditions is an imperative aspect of the crop improvement programme. The role of plant hormones is well-established in abiotic stress tolerance. However, the information on the role of gibberellic acid (GA) in abiotic stress tolerance in late sown wheat is still not thoroughly explored. Thus, we aimed to investigate the role of endogenous GA3 level in stress tolerance in contrasting wheat cultivars, viz., temperature-tolerant (HD 2643 and DBW 14) and susceptible (HD 2189 and HD 2833) cultivars under timely and late sown conditions. We created the variation in endogenous GA3 level by exogenous spray of GA3 and its biosynthesis inhibitor paclobutrazol (PBZ). Tolerant genotypes had higher antioxidant enzyme activity, membrane stability, and photosynthesis rate, lower lipid peroxidase activity, and better growth and yield traits under late sown conditions attributed to H2O2 content. Application of PBZ escalated antioxidant enzymes activity and photosynthesis rate, and reduced the lipid peroxidation and ion leakage in stress, leading to improved thermotolerance. GA3 had a non-significant effect on antioxidant enzyme activity, lipid peroxidation, and membrane stability. However, GA3 application increased the test weight in HD 2643 and HD 2833 under timely and late sown conditions. GA3 upregulated GA biosynthesis and degradation pathway genes, and PBZ downregulated kaurene oxidase and GA2ox gene expression. GA3 also upregulated the expression of the cell expansins gene under both timely and late sown conditions. Exogenous GA3 did not increase thermotolerance but positively affected test weight and cell expansins gene expression. No direct relationship existed between endogenous GA3 content and stress tolerance traits, indicating that PBZ could have conferred thermotolerance through an alternative mechanism instead of inhibiting GA3biosynthesis.
Effect and Response of Quercus ilex subsp. ballota [Desf.] Samp. Seedlings From Three Contrasting Andalusian Populations to Individual and Combined Phytophthora cinnamomi and Drought Stresses
Authors: San-Eufrasio Bonoso , Castillejo María Ángeles , Labella-Ortega Mónica , Ruiz-Gómez Francisco J. , Navarro-Cerrillo Rafael M. , Tienda-Parrilla Marta , Jorrín-Novo Jesús V. , Rey María-Dolores
Published: August 2021

Quercus ilex L. is the dominant species in the Mediterranean forest and agrosilvopastoral ecosystem “dehesa.” Currently, this forest species is threatened by natural and anthropogenic agents, especially by the decline syndrome, which is caused by Phytophthora cinnamomi and drought periods. Although the morphological and physiological responses of Q. ilex to combined stress (P. cinnamomi and drought) have been examined already, little is known at the molecular level. In this study, we studied the effect and response of 8-month seedlings from three contrasting Andalusian populations (Seville [Se], Granada [Gr], and Almeria [Al]) to the individual and combined stresses of P. cinnamomi and drought from morphological, physiological, biochemical, and proteomics data. Whereas, seedling damage (leaf chlorosis and necrosis) and mortality were greater under the combined stresses in the three populations, the effect of each individual stress was population-dependent. Resilient individuals were found in all the populations at different percentages. The decrease in leaf chlorophyll fluorescence, photosynthetic activity, and stomatal conductance observed in undamaged seedlings was greater in the presence of both stresses, the three populations responding similarly to drought and P. cinnamomi. Biochemical and proteomic analyses of undamaged seedlings from the two most markedly contrasting populations (Se and Al) revealed the absence of significant differences in the contents in photosynthetic pigments, amino acids, and phenolics among treatments. The Se and Al populations exhibited changes in protein profile in response to the different treatments, with 83 variable proteins in the former population and 223 in the latter. Variable proteins belonged to 16 different functional groups, the best represented among which were protein folding, sorting and degradation, carbohydrate, amino acid, and secondary metabolism, photosynthesis, and ROS scavenging. While photosynthetic proteins were mainly downaccumulated, those of stress-responsive were upaccumulated. Although no treatment-specific response was observed in any functional group, differences in abundance were especially marked under the combined stresses. The following variable proteins are proposed as putative markers for resilience in Q. ilex, namely, aldehyde dehydrogenase, glucose-6-phosphate isomerase, 50S ribosomal protein L5, and α-1,4-glucan-protein synthase [UDP-forming].
Exploratory Graph Analysis of the Strengths and Difficulties Questionnaire for Aboriginal and/or Torres Strait Islander Children
Authors: Santiago Pedro Henrique Ribeiro , Manzini Macedo Davi , Haag Dandara , Roberts Rachel , Smithers Lisa , Hedges Joanne , Jamieson Lisa
Published: August 2021

In Australia, one of the most frequently used measures for assessing social and emotional well-being (SEWB) of Aboriginal and/or Torres Strait Islander children is the Strengths and Difficulties Questionnaire (SDQ). Previous studies on state-level validations have indicated the problems associated with the original five-factor SDQ structure, especially in the dimension of Peer Problems. The aim of this study was to use a novel psychometric methodology, namely Exploratory Graph Analysis (EGA), to evaluate the dimensionality of caregiver-informant SDQ version 4–10 years at a national level in Australia. Data for this study were retrospectively collected from two independent longitudinal studies: the Longitudinal Study of Indigenous Children (LSIC) and South Australian Aboriginal Birth Cohort (SAABC). The caregiver-informed SDQ version 4–10 years was applied across several study waves, including more than 4,000 responses. To conduct EGA, Gaussian graphical models (GGMs) were estimated using the Least Absolute Shrinkage and Selection Operator. About 2,500 bootstrap samples were also employed to investigate dimensions and item stability. The findings indicated robust evidence against the construct validity of the original five-factor SDQ structure. Future studies should conduct a direct external validation of the findings with Aboriginal and/or Torres Strait Islander parents/carers and community groups to develop the guidelines for future use of the instrument among Aboriginal and/or Torres Strait Islander children in Australia.
Experiences That Matter: Unraveling the Link Between Extracurricular Activities and Emotional and Social Competencies
Authors: Cortellazzo Laura , Bonesso Sara , Gerli Fabrizio , Pizzi Claudio
Published: August 2021

Emotional and social competencies have been shown to be extremely desirable in young people for their successful entry into the labor market. Their development has been studied primarily as a result of formal training in the educational and work domains, whereas relatively little is known about the role played by extracurricular activities in promoting these types of competencies. Non-working personal experiences are often used as proxies to assess the emotional and social competencies of candidates in recruitment and selection phases. However, this inference is not based on clear scientific evidence. Drawing on experiential learning theory, this study investigated empirically the relationship between a range of extracurricular activities (volunteering, cultural activities, experience abroad, sport) and the competency portfolio of graduates. Data were collected from a sample of 324 graduates through a structured survey and a multi-rater assessment of their emotional and social competencies. The results of the Partial Least Square-Path Modeling in general provide support for the positive association between experiential extracurricular activities and emotional and social competencies, although not all relationships are supported. The present study contributes to advance in the understanding of the determinants of emotional and social competencies by examining their relationship with a broad range of extracurricular activities. Moreover, it discusses implications for higher education and human resource management.
The Acquisition of Noun and Verb Categories by Bootstrapping From a Few Known Words: A Computational Model
Authors: Brusini Perrine , Seminck Olga , Amsili Pascal , Christophe Anne
Published: August 2021

While many studies have shown that toddlers are able to detect syntactic regularities in speech, the learning mechanism allowing them to do this is still largely unclear. In this article, we use computational modeling to assess the plausibility of a context-based learning mechanism for the acquisition of nouns and verbs. We hypothesize that infants can assign basic semantic features, such as “is-an-object” and/or “is-an-action,” to the very first words they learn, then use these words, the semantic seed, to ground proto-categories of nouns and verbs. The contexts in which these words occur, would then be exploited to bootstrap the noun and verb categories: unknown words are attributed to the class that has been observed most frequently in the corresponding context. To test our hypothesis, we designed a series of computational experiments which used French corpora of child-directed speech and different sizes of semantic seed. We partitioned these corpora in training and test sets: the model extracted the two-word contexts of the seed from the training sets, then used them to predict the syntactic category of content words from the test sets. This very simple algorithm demonstrated to be highly efficient in a categorization task: even the smallest semantic seed (only 8 nouns and 1 verb known) yields a very high precision (~90% of new nouns; ~80% of new verbs). Recall, in contrast, was low for small seeds, and increased with the seed size. Interestingly, we observed that the contexts used most often by the model featured function words, which is in line with what we know about infants' language development. Crucially, for the learning method we evaluated here, all initialization hypotheses are plausible and fit the developmental literature (semantic seed and ability to analyse contexts). While this experiment cannot prove that this learning mechanism is indeed used by infants, it demonstrates the feasibility of a realistic learning hypothesis, by using an algorithm that relies on very little computational and memory resources. Altogether, this supports the idea that a probabilistic, context-based mechanism can be very efficient for the acquisition of syntactic categories in infants.
Sensitivity to Communication Partners During Naturalistic AAC Conversations in Cantonese Chinese
Authors: Yum Yen Na , So Soby Ka Wing , Chan Rosanna Yuen-Yan
Published: August 2021

Previous studies have shown that graphic-based augmentative and alternative communication (AAC) output tend to be short and simple in structure with non-canonical word order, and that AAC users may show differences when communicating with peers compared to professionals such as speech therapists (STs). However, there was a lack of report for graphic-based AAC in the Chinese context, and the effect of communication partners had not been investigated systematically. In this study with 34 AAC users and 10 STs, we reported common and distinct features of free conversations in Cantonese graphic-based AAC, relative to AAC in other languages. We also found that AAC users were sensitive to different types of communication partners. In particular, when conversing with peers, AAC users produced long messages with equal proportion of questions and responses, which suggested active and bi-directional exchanges. In conversations with STs, AAC users showed high diversity in expressive vocabulary, indicating access to more semantic concepts. Results suggested that the base language and the communication partner are both influential factors that should be considered in studies of graphic-based AAC. The mobile AAC system facilitated free conversations in users with complex communication needs, affording an additional channel for social participation.
The Community-Engaged Lab: A Case-Study Introduction for Developmental Science
Authors: Liu Judy , Partington Scott , Suh Yeonju , Finiasz Zoe , Flanagan Teresa , Kocher Deanna , Kiely Richard , Kortenaar Michelle , Kushnir Tamar
Published: August 2021

Due to the closing of campuses, museums, and other public spaces during the pandemic, the typical avenues for recruitment, partnership, and dissemination are now unavailable to developmental labs. In this paper, we show how a shift in perspective has impacted our lab's ability to successfully transition to virtual work during the COVID-19 shut-down. This begins by recognizing that any lab that relies on local communities to engage in human research isitself a community organization. From this, we introduce acommunity-engaged labmodel, and explain how it works using our own activities during the pandemic as an example. To begin, we introduce the vocabulary of mission-driven community organizations and show how we applied the key ideas of mission, vision, and culture to discussions of our own lab's identity. We contrast the community-engaged lab model with a traditional bi-directional model of recruitmentfromand disseminationtocommunities and describe how the community-engaged model can be used to reframe these and other ordinary lab activities. Our activities during the pandemic serve as a case study: we formed new community partnerships, engaged with child “citizen-scientists” in online research, and opened new avenues of virtual programming. One year later, we see modest but quantifiable impact of this approach: a return to pre-pandemic diversity in our samples, new engagement opportunities for trainees, and new sustainable partnerships. We end by discussing the promise and limitations of the community-engaged lab model for the future of developmental research.
Factors Associated With Low Self-Esteem Among Patients With Hematologic Malignancies: A Cross-Sectional Study
Authors: Yu Junye , Dong Huan , Wu Qi , Yang Ya , Pi Hongying
Published: August 2021

The present study aimed to explore the self-esteem level of patients with hematology malignancies and the associated factors. In this cross-sectional study, we screened patients with hematologic malignancies treated in the Department of Hematology of Aerospace Center Hospital between November 2019 and June 2020. We included 157 eligible patients by convenience sampling. The participants completed questionnaires covering demographic characteristics, loneliness, the coping styles, hope, five personality traits, and self-esteem level. We applied t-test, analysis of variance, simple linear regression, and multiple stepwise regression to explore the factors associated with patients' self-esteem. The mean self-esteem score of hematology tumor patients was 26.86 ± 2.34, which was lower than the national norm (P < 0.01). The multiple stepwise regression analysis identified maintaining close relationships with others, conscientiousness, extroversion, agreeableness, and positive coping style as factors independently associated with the self-esteem of hematology tumor patients. Patients with hematologic malignancies experience low self-esteem. Factors including maintaining close relationships with others, conscientiousness, extraversion, agreeableness, and active coping style were found to be independently associated with the self-esteem level of these patients. For patients with hematologic malignancies, health providers should apply patient-centered and targeted interventions to improve patients' self-esteem, reduce adverse psychological emotions, and improve their quality of life.
The LIFEwithIBD Intervention: Study Protocol for a Randomized Controlled Trial of a Face-to-Face Acceptance and Commitment Therapy and Compassion-Based Intervention Tailored to People With Inflammatory Bowel Disease
Authors: Trindade Inês A. , Pereira Joana , Galhardo Ana , Ferreira Nuno B. , Lucena-Santos Paola , Carvalho Sérgio A. , Oliveira Sara , Skvarc David , Rocha Bárbara S. , Portela Francisco , Ferreira Cláudia
Published: August 2021

Background:There is ample evidence of the high mental health burden caused by Inflammatory Bowel Disease (IBD). Several constructs such as experiential avoidance, cognitive fusion, shame, and self-criticism have recently emerged as potential intervention targets to improve mental health in IBD. Psychotherapeutic models such as Acceptance and Commitment Therapy and compassion-based interventions are known to target these constructs. In this protocol, we aim to describe a two-arm Randomized Controlled Trial (RCT) testing the efficacy of an ACT and compassion-focused intervention named Living with Intention, Fullness, and Engagement with Inflammatory Bowel Disease (LIFEwithIBD) intervention + Treatment As Usual (TAU) vs. TAU in improving psychological distress, quality of life, work and social functioning, IBD symptom perception, illness-related shame, psychological flexibility, self-compassion, disease activity, inflammation biomarkers, and gut microbiota diversity.

Methods:This trial is registered atClinicalTrials.gov(Identifier: NCT03840707, date assigned 13/02/2019). The LIFEwithIBD intervention is an adaptation to the IBD population of the Mind programme for people with cancer, an acceptance, mindfulness, and compassion-based intervention designed to be delivered in a group format. The LIFEwithIBD intervention's structure and topics are presented in this protocol. Participants were recruited at the Gastroenterology Service of the Coimbra University Hospital between June and September 2019. Of the 355 patients screened, 61 participants were selected, randomly assigned to one of two conditions [experimental group (LIFEwithIBD + TAU) or control group (TAU)] and completed the baseline assessment. Outcome measurement took place at baseline, post-intervention, 3- and 12-month follow-ups.

Discussion:Results from this RCT will support future studies testing the LIFEwithIBD intervention or other acceptance and/or compassion-based interventions for IBD.
Case Report: Cariprazine in a Patient With Schizophrenia, Substance Abuse, and Cognitive Dysfunction
Authors: Rodriguez Cruz Jose , Sahlsten Schölin Johan , Hjorth Stephan
Published: August 2021

This case report describes a 30-year old male diagnosed with schizophrenia at the age of 23, and with a long history of drug abuse. He had previously received a wide range of antipsychotic drug treatment regimens, all with some degree of effect, but never with complete symptom relief. He was also suffering from persistent cognitive and negative symptoms. At the time of admission in our clinic, he was on Quetiapine (QUE) and Haloperidol (HAL). It was therefore decided to substitute HAL for Cariprazine (CAR)—an agent with a novel pharmacological and clinical profile—in the hope of gaining increased efficacy, particularly in the cognitive and negative symptom domains. Within 3 weeks of the switch from HAL to CAR the patient clearly improved, and notably so in the aforementioned symptom areas. A number of subsequent adjustments of antipsychotic dosages and adjunct medications during the ensuing months resulted in an apparently more stable alleviation of positive as well as negative and cognitive symptoms, including markedly improved personal and social capabilities. Interestingly, some time after initiating CAR treatment the patient also reported that from being a heavy smoker (60 cig/d) he had cut down and eventually ceased smoking entirely; furthermore, he has remained clean of other substance abuse since his first admission in 2020. The joint treatment with CAR in combination with QUE thus seems to have improved the patient's cognitive functioning as well as possibly his susceptibility to substance abuse.
The Comparison Between Different Hospital Market Definition Approaches: An Empirical Analysis of 11 Representative Diseases in Sichuan Province, China
Authors: Lu Liyong , Chen Ting , Lan Tianjao , Pan Jay
Published: August 2021

Objective:This study aims to provide empirical evidence for the controversy about whether the inference is consistent if alternative hospital market definition methods are employed, and for which definition method is the best alternative to the predicted patient flow approach.

Data sources:Collecting data from the discharge data of inpatients and hospital administrative data of Sichuan province in China in the fourth quarter of 2018.

Study Design:We employed Herfindahl–Hirschman Index (HHI) as the proxy of market competition used as an example to measure the hospital market structure. Correlation coefficients of HHIs based on different definition methods were assessed. The corresponding coefficient of each HHI estimated in identical regression models was then compared. In addition, since the predicted patient flow method has been argued by the literature of its advantages compared with the previous approaches, we took the predicted patient flow as a reference to compare with the other approaches.

Data Extraction Methods:We selected the common diseases with a significant burden, and 11 diseases were included (902,767 hospitalizations).

Principal Findings:The correlation coefficients of HHIs based on different market definition methods are all significantly greater than 0, and the coefficients of HHIs are different in identical regression models. Taking the predicted patient flow approach as a reference, we found that the correlation coefficients between HHIs based on fixed radius and predicted patient flow approach is larger than others, and their parameter estimates are all consistent.

Conclusion:Although the HHIs based on different definition methods are significantly and positively correlated, the inferences about the effectiveness of market structure would be inconsistent when alternative market definition methods are employed. The fixed radius would be the best alternative when researchers want to use the predicted patient flow method to define the hospital market but are hindered by the data limitations and computational complexity.
Case Report: Occupational Dust Exposure Among Bakery Workers in Perth, Western Australia
Authors: Rumchev Krassi , Zhao Yun , Lee Andy
Published: August 2021

Occupational dust exposure can occur in various settings, including bakeries. A case study was conducted in an industrial bakery in Perth, Western Australia, to assess exposure to particulate dust concentration. The factory was separated into three production zones and an office area which represented as a control zone. Results indicated that bakery workers in the production zones were exposed to higher ambient dust particle concentrations compared to those from the office environment. Coarse particles (>10 μm in aerodynamic diameter) were the predominant particle size fraction measured in all studied areas with the highest median exposure level recorded in the dough room (0.181 mg/m3, interquartile range 0.283). High personal concentration of respirable particles was also measured in the dough room (median 2.26 mg/m3) which exceeded the recommended limit of 1.5 mg/m3 and was more than 50 times higher than the concentration recorded in the office (0.04 mg/m3). The variation in dust concentrations between production zones underlines the need of more knowledge about how aerosol fractions are distributed across the production process. The findings also suggest that bakery workers are exposed to high dust levels that may increase their risk of developing respiratory diseases and the decrease of present exposure levels is imperative.
Anomalies in the Cosmic Microwave Background and Their Non-Gaussian Origin in Loop Quantum Cosmology
Authors: Agullo Ivan , Kranas Dimitrios , Sreenath V.
Published: August 2021

Anomalies in the cosmic microwave background (CMB) refer to features that have been observed, mostly at large angular scales, and which show some tension with the statistical predictions of the standard ΛCDM model. In this work, we focus our attention on power suppression, dipolar modulation, a preference for odd parity, and the tension in the lensing parameterAL. Though the statistical significance of each individual anomaly is inconclusive, collectively they are significant, and could indicate new physics beyond the ΛCDM model. In this article, we present a brief, but pedagogical introduction to CMB anomalies and propose a common origin in the context of loop quantum cosmology.
Emergence of a tet(M) Variant Conferring Resistance to Tigecycline in Streptococcus suis
Authors: Yu Rui , Zhang Yue , Xu Yindi , Schwarz Stefan , Li Xin-Sheng , Shang Yan-Hong , Du Xiang-Dang
Published: August 2021

The aim of this study was to gain insight into the resistance determinants conferring resistance to tigecycline in Streptococcus (S.) suis and to investigate the genetic elements involved in their horizontal transfer. A total of 31 tetracycline-resistant S. suis isolates were screened for tigecycline resistance by broth microdilution. S. suis isolate SC128 was subjected to whole genome sequencing with particular reference to resistance determinants involved in tigecycline resistance. Transferability of genomic island (GI) GISsuSC128 was investigated by transformation. The roles of tet(L) or tet(M) in contributing to tigecycline resistance in S. suis were confirmed by transformation using different tet(L)- or tet(M)-carrying constructs. Only S. suis SC128 showed a tigecycline resistance phenotype. A tet(L)-tet(M) and catA8 co-carrying GISsuSC128 was identified in this isolate. After transfer of the novel GI into a susceptible recipient, this recipient showed the same tigecycline resistance phenotype. Further transfer experiments with specific tet(L)- or tet(M)-carrying constructs confirmed that only tet(M), but not tet(L), contributes to resistance to tigecycline. Protein sequence analysis identified a Tet(M) variant, which is responsible for tigecycline resistance in S. suis SC128. It displayed 94.8% amino acid identity with the reference Tet(M) of Enterococcus faecium DO plasmid 1. To the best of our knowledge, this is the first time that a tet(M) variant conferring resistance to tigecycline was identified in S. suis. Its location on a GI will accelerate its transmission among the S. suis population.
Constructivismo e integración en psicoterapia
Authors: Feixas Guillem
Published: August 2021

La perspectiva constructivista conlleva un buen criterio de implicaciones significativas de integracion de las psicoterapias .
Tourism Demand Forecasting Based on an LSTM Network and Its Variants
Authors: Hsieh Shun-Chieh
Published: August 2021

The need for accurate tourism demand forecasting is widely recognized. The unreliability of traditional methods makes tourism demand forecasting still challenging. Using deep learning approaches, this study aims to adapt Long Short-Term Memory (LSTM), Bidirectional LSTM (Bi-LSTM), and Gated Recurrent Unit networks (GRU), which are straightforward and efficient, to improve Taiwan’s tourism demand forecasting. The networks are able to seize the dependence of visitor arrival time series data. The Adam optimization algorithm with adaptive learning rate is used to optimize the basic setup of the models. The results show that the proposed models outperform previous studies undertaken during the Severe Acute Respiratory Syndrome (SARS) events of 2002–2003. This article also examines the effects of the current COVID-19 outbreak to tourist arrivals to Taiwan. The results show that the use of the LSTM network and its variants can perform satisfactorily for tourism demand forecasting.
Physical Attributes of Ferralsol in Fertigated Sugarcane Production Environments for Bioethanol in the Midwest of Brazil
Authors: Gravina Otavio Silveira , Santos Glenio Guimarães , Correchel Vladia , Silva Gustavo Cassiano da , Medrado Lucas de Castro , Flores Rilner Alves , Mesquita Márcio , Severiano Eduardo da Costa
Published: August 2021

Brazil is the world leader in the production and export of sugarcane derivatives, and its center-south region is the main producer. Fertigation with byproducts from bioethanol production can be adopted as a strategy to mitigate the soil physical deterioration resulting from the intensification of mechanized farming practices. The objective of this study was to evaluate the behavior of soil physical attributes under sugarcane cultivation in different crop cycles in fertigated areas in the midwest region of Brazil. The samples were collected in different Ferralsol layers (0.0–0.1, 0.1–0.2, 0.2–0.3, and 0.4–0.5 m) and fertigated crop cycles (first, third, fifth, seventh, and twelfth sugarcane cycles), as well as from native Cerrado vegetation (reference area), and the weight and volume relationships of the soil constituents and total soil were evaluated. Soil physical attributes are affected by sugarcane cultivation cycles and fertigation with vinasse. In the short term (third cycle), the results indicate deterioration of the physical attributes of the soil. However, throughout the cycles of sugarcane culture via fertigation (twelve cycles), the addition of vinasse leads to improvements in physical attributes and soil aggregation, promoting an increase in the longevity of the sugarcane crop. Therefore, the evaluation of the physical attributes of the soil in areas with vinasse application in different sugarcane cultivation cycles should be analyzed in areas of different regions, as this management practice indicates a high potential to increase the longevity of cultivation sugarcane, reducing production costs in the bioenergy sector.
Cactus Pear (Opuntia ficus-indica) Productivity, Proximal Composition and Soil Parameters as Affected by Planting Time and Agronomic Management in a Semi-Arid Region of India
Authors: Kumar Sunil , Louhaichi Mounir , Dana Ram Palsaniya , Tirumala Kiran Kumar , Ahmad Shahid , Rai Arvind Kumar , Sarker Ashutosh , Hassan Sawsan , Liguori Giorgia , Probir Kumar Ghosh , Govindasamy Prabhu , Prasad Mahendra , Mahawer Sonu Kumar , Hulgathur Appaswamygowda Bhargavi
Published: August 2021

Study of appropriate planting time and response to agronomic management practices is imperative for the newly introduced cactus pear (Opuntia ficus-indica (L.) Mill.) into a semi-arid region of India. Responses of cactus pear to agronomic practices (planting time and irrigation and fertilizer application) were evaluated to determine the potential for fodder production and livestock feed in a semi-arid environment of India. We assessed four planting times (February, March, July and October) and two agronomic managements (with and without irrigation and fertilizer application) during 2016–2020 at Jhansi, India. Cactus pear establishment and growth improved with planting time in July and October due to favorable soil moisture and congenial temperature. However, plant height (19 cm) and cladode weight (118 g) were greater in July than in October planting. Nutrient uptake and crude protein contents, however, were higher for the earlier plantings of February and April compared to June and October. Irrigation and nutrients application had little effect on the cactus pear plant growth, except on plant width and cladode length and width. Cactus pear can be planted during July in moderately fertile soils without any agronomic intervention in semi-arid situations of India and has potential as an effective alternative source of forage for livestock during the summer months.
Effect of the Short-Term Incorporation of Different Proportions of Ensiled Artichoke By-Product on Milk Parameters and Health Status of Dairy Goats
Authors: Monllor Paula , Muelas Raquel , Roca Amparo , Bueso-Ródenas Joel , Atzori Alberto Stanislao , Sendra Esther , Romero Gema , Díaz José Ramón
Published: August 2021

The use of local agricultural by-products for animal feed is an alternative that reduces livestock production costs and allows food production of greater environmental sustainability. The aim of this experiment was to study the effect of the inclusion in the dairy goat ration of artichoke by-product silage (ABS) at three levels (25%, 40% and 60%, on a dry matter basis) on the milk yield, composition and quality, and on the metabolic profile of dairy goats. Thirty-six Murciano-Granadina dairy goats in mid-lactation were divided into four groups with homogeneous characteristics. Each group was assigned a diet: a control treatment (C) that consisted of a conventional diet of alfalfa hay and concentrate, and three other treatments that included 25, 40 and 60% ABS: ABS25, ABS40 and ABS60. Small differences were observed in the milk yield and quality and the health status of the animals. Only ABS60 presented a slightly lower milk yield (−20% compared to control group), without relevant differences in the milk composition and mineral profile. Regarding the lipid profile, ABS40 was the treatment with the best milk quality, due to a higher content of polyunsaturated fatty acids (4.37%) and lower atherogenicity (1.90) and thrombogenicity indices (3.05), without differences from C. It was concluded that the maximum inclusion level of ABS in dairy goats’ diet should be equal to 40%.
Vision Based Drone Obstacle Avoidance by Deep Reinforcement Learning
Authors: Xue Zhihan , Gonsalves Tad
Published: August 2021

Research on autonomous obstacle avoidance of drones has recently received widespread attention from researchers. Among them, an increasing number of researchers are using machine learning to train drones. These studies typically adopt supervised learning or reinforcement learning to train the networks. Supervised learning has a disadvantage in that it takes a significant amount of time to build the datasets, because it is difficult to cover the complex and changeable drone flight environment in a single dataset. Reinforcement learning can overcome this problem by using drones to learn data in the environment. However, the current research results based on reinforcement learning are mainly focused on discrete action spaces. In this way, the movement of drones lacks precision and has somewhat unnatural flying behavior. This study aims to use the soft-actor-critic algorithm to train a drone to perform autonomous obstacle avoidance in continuous action space using only the image data. The algorithm is trained and tested in a simulation environment built by Airsim. The results show that our algorithm enables the UAV to avoid obstacles in the training environment only by inputting the depth map. Moreover, it also has a higher obstacle avoidance rate in the reconfigured environment without retraining.