bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechano-Synthesis, Structure, and Thermal and Magnetic Behaviors of the New Compound Mn1.2Co0.05Fe0.7P0.45Si0.5B0.05
Authors: Khitouni Nawel , Almoneef Maha M. , Mili Amira , Khitouni Mohamed , Wederni Asma , Suñol Joan-Josep
Published: February 2024

The Mn1.2Co0.05Fe0.7P0.45Si0.5B0.05 compound has been systematically synthesized by mechanical alloying for 15 h, followed by annealing with two heating cycles at 1373 K for 2 h and 1073 K for 24 h. The powder that was milled for 15 h revealed the main hexagonal-Mn2P-type phase and the minor cubic-Mn3Fe2Si phase through X-ray diffraction examination. After annealing the same powder at 1373 K for 2 h and again at 1073 K for 24 h, the refined phase was the unique (Mn, Fe)2(P, Si) type with a hexagonal structure. For the mechanically alloyed powder, the final crystallite size was approximately 20 nm, and it rose to 95 nm during the annealing process. Further, a large amount of lattice microstrain was achieved as a result of high-energy milling (about 0.75%). Over the whole temperature range of 373 to 923 K, the thermal analysis showed several overlapping exothermic peaks, which indicated the improvement of the microstructure after the structural relaxation and reordering process. Moreover, the Curie temperature of the alloy was retrieved at approximately 675 K. According to an analysis of the magnetic properties, the mechanically alloyed powder exhibited an exceptional soft ferromagnetic state after 15 h of milling, and the annealed alloy showed superparamagnetic characteristics.
Flight Dispersal in Supratidal Rockpool Beetles
Authors: Plaza-Buendía Jorge , Mirón-Gatón Juana María , García-Meseguer Antonio José , Villastrigo Adrián , Millán Andrés , Velasco Josefa
Published: February 2024

Flight dispersal is ecologically relevant for the survival of supratidal rockpool insects. Dispersal has important consequences for colonisation, gene flow, and evolutionary divergence. Here, we compared the flight dispersal capacity of two congeneric beetle species (Ochthebius quadricollis and Ochthebius lejolisii) that exclusively inhabit these temporary, fragmented, and extreme habitats. We estimated flight capacity and inferred dispersal in both species using different approaches: experimental flying assays, examination of wing morphology, and comparison of microsatellite markers between species. Our findings revealed that both species exhibited similar flight behaviour, with 60 to 80% of the individuals flying under water heating conditions. Notably, females of both species had larger body sizes and wing areas, along with lower wing loading, than males in O. quadricollis. These morphological traits are related to higher dispersal capacity and more energetically efficient flight, which could indicate a female-biassed dispersal pattern. The wing shapes of both species are characterised by relatively larger and narrower wings in relation to other species of the genus, suggesting high flight capacity at short distances. Molecular data revealed in both species low genetic divergences between neighbouring populations, non-significant differences between species, and no isolation by distance effect at the study scale (<100 km). These results point to passive dispersal assisted by wind.
Understanding the Application of Mechanical Dyssynchrony in Patients with Heart Failure Considered for CRT
Authors: Dutta Abhishek , Alqabbani Rakan , Hagendorff Andreas , Tayal Bhupendar
Published: February 2024

Over the past two decades of CRT use, the failure rate has remained around 30–35%, despite several updates in the guidelines based on the understanding from multiple trials. This review article summarizes the role of mechanical dyssynchrony in the selection of heart failure patients for cardiac resynchronization therapy. Understanding the application of mechanical dyssynchrony has also evolved during these past two decades. There is no role of lone mechanical dyssynchrony in the patient selection for CRT. However, mechanical dyssynchrony can complement the electrocardiogram and clinical criteria and improve patient selection by reducing the failure rate. An oversimplified approach to mechanical dyssynchrony assessment, such as just estimating time-to-peak delays between segments, should not be used. Instead, methods that can identify the underlying pathophysiology of HF and are representative of a substrate to CRT should be applied.
The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review
Authors: Braga Yarlla Loyane Lira , do Carmo Neto José Rodrigues , Franco Pablo Igor Ribeiro , Helmo Fernanda Rodrigues , dos Reis Marlene Antônia , de Oliveira Flávia Aparecida , Celes Mara Rúbia Nunes , da Silva Marcos Vinícius , Machado Juliana Reis
Published: February 2024

Fibrosis is one of the main factors that impair the function of many organs. In the heart, fibrosis leads to contractile dysfunction and arrhythmias, which are important in the development of heart failure. Interleukin (IL)-11 is regulated in various heart diseases and has recently been reported to be an important cytokine in fibrosis in this organ. However, this topic has been little explored, and many questions persist. Thus, this systematic review aimed to report on possible IL-11 therapies evaluated in rodent model-induced cardiac fibrosis. Inclusion criteria were experimental in vivo studies that used different rodent models for cardiac fibrosis associated with IL-11 interventions, without year and language restrictions. The search in PubMed, Web of Science, and Embase databases was performed in October 2022. The risk of bias assessment of the studies was based on the guidelines of the SYRCLE tool, and data from the selected articles were also presented in a table as a narrative description. This review was based on eight studies in which five different interventions were used: recombinant human IL-11 (rhIL-11), anti-IL11 (X203), recombinant mouse IL-11 (rmIL-11), lentivirus (LV)-IL-11 + lutein, and anti-IL11RA (X209). Based on the included studies, the results were variable, with IL-11 overexpression inducing cardiac fibrosis, while inhibition protected against this process, preserving the function of this organ. Therefore, IL-11 stands out as a promising therapeutic target for cardiac fibrosis. However, further studies are needed to understand the mechanisms triggered by each treatment, as well as its safety and immunogenicity.
Effects of Sociodemographic Factors on Access to and Outcomes in Congenital Heart Disease in the United States
Authors: Robinson Justin , Sahai Siddhartha , Pennacchio Caroline , Sharew Betemariam , Chen Lin , Karamlou Tara
Published: February 2024

Congenital heart defects (CHDs) are complex conditions affecting the heart and/or great vessels that are present at birth. These defects occur in approximately 9 in every 1000 live births. From diagnosis to intervention, care has dramatically improved over the last several decades. Patients with CHDs are now living well into adulthood. However, there are factors that have been associated with poor outcomes across the lifespan of these patients. These factors include sociodemographic and socioeconomic positions. This commentary examined the disparities and solutions within the evolution of CHD care in the United States.
Modifications in Upper Airway Collapsibility during Sleep Endoscopy with a Mandibular Positioner: Study in Snorers and Obstructive Sleep Apnea Patients
Authors: Fernández-Sanjuán Patricia , Alcaraz Marta , Bosco Gabriela , Pérez-Martín Nuria , Morato Marta , Lugo Rodolfo , Arrieta Juan José , Sanabria Jaime , Ríos-Lago Marcos , Plaza Guillermo
Published: February 2024

Background: Mandibular advancement devices (MADs) are an effective treatment for patients with sleep-related breathing disorders, with variable response. Increasingly more research points to the predictive value of Drug-Induced Sleep Endoscopy (DISE) in patient selection. This study aims to analyze the changes in upper airway collapsibility using a titratable MAD simulator during DISE. Methods: This study included 104 patients with simple snoring and obstructive sleep apnea (OSA). The VOTE scale was used to assess the presence of collapses during the DISE both without and with the MAD simulator. Results: In snorers, there was a decrease in collapses at the level of the soft palate and oropharynx when the advancement was achieved. Patients with mild OSA also showed a decrease in collapses at the base of the tongue. Patients with moderate/severe OSA exhibited significant amelioration at all levels. The levels at which there were residual collapses despite the maneuver were, in order, the velopharynx, oropharynx, epiglottis, and tongue. Conclusions: The MAD simulator reduces collapsibility at all levels and in all severity groups. Residual collapses suitable for combined treatments were able to be identified. This highlights the need for individualized patient selection, as upper airway collapsibility exhibits variable improvement or worsening with the MAD simulator regardless of the severity of the condition.
Predictive Factors of Functional Outcomes and Quality of Life in Patients with Ankle Fractures: A Systematic Review
Authors: Lorente Alejandro , Pelaz Leire , Palacios Pablo , Benlloch María , de la Rubia Ortí José Enrique , Barrios Carlos , Mariscal Gonzalo , Lorente Rafael
Published: February 2024

Background: Evaluating the predictors of unfavorable outcomes in patients with ankle fractures is crucial for identifying high-risk patients and implementing personalized treatment strategies. This study aimed to analyze factors that influence quality of life in patients with ankle fractures. Methods: Four databases were consulted. The main outcomes were functionality and quality of life scales combined using the standard mean difference (SMD) (Review Manager 5.4). Results: Eight studies with 2486 patients were included. A significant correlation was found between female sex and worse functionality scores (beta 4.15, 95% CI 1.84–6.46). Additionally, older age was correlated with worse functionality scores (beta −0.24, 95% CI −0.29 to −0.19). Patients with diabetes or metabolic syndrome also had worse outcomes (SMD 0.27, 95% CI 0.18–0.36). High BMI and obesity were also associated with worse quality of life scores (beta 2.62, 95% CI 0.77–4.48). Smokers had greater disability in the analyzed scales (SMD 0.22, 95% CI 0.05–0.39). No significant differences were observed with respect to syndesmotic involvement. Conclusions: Age, sex, diabetes, high BMI, and smoking negatively impact functional outcomes and quality of life in patients with ankle fractures.
Assessment of Integrative Therapeutic Methods for Improving the Quality of Life and Functioning in Cancer Patients—A Systematic Review
Authors: Iliescu Mădălina Gabriela , Stanciu Liliana-Elena , Uzun Andreea-Bianca , Cristea Adelina-Elena , Motoască Irina , Irsay Laszlo , Iliescu Dan Marcel , Vari Titus , Ciubean Alina Deniza , Caraban Bogdan Marian , Ciufu Nicolae , Azis Olgun , Ciortea Viorela Mihaela
Published: February 2024

Background: Cancer rehabilitation represents a series of measures adopted for the recovery of psychological, emotional, social, and financial functioning in the case of cancer patients. The purpose of this study is to identify the main elements of therapeutic management in the field of medical rehabilitation, as well as integrative, complementary medicine and holistic approaches that can be performed on the oncological patient. Methods: This systematic literature review follows the methodology outlined in the “Preferred Reporting Items for Systematic Reviews and Meta-Analysis” (“PRISMA”) statement, which is an internationally recognized and widely accepted standard. Results: Active rehabilitative therapies offer therapeutic options for improving the functioning and quality of life of oncological patients; these therapies comprehensively address both the physical and psychological aspects of the disease. This review also includes the latest novelties and nanotechnologies applied in oncological rehabilitation, for example, drugs (or supplements) inspired by nature. Conclusions: Physical and rehabilitation medicine, mostly using stimulating therapeutic methods, was recently added to the list of contraindications in the management of oncological patients, both as an approach to the pathological concept itself and as an approach to the main clinical consequences and functional aspects of oncological therapies. Integrative, complementary medicine presents an important therapeutic resource in the case of oncological patients. Advanced studies are needed in the future to further ascertain the role of these therapies.
Current Concepts of Cervical Spine Alignment, Sagittal Deformity, and Cervical Spine Surgery
Authors: Suzuki Hidenori , Funaba Masahiro , Fujimoto Kazuhiro , Ichihara Yusuke , Nishida Norihiro , Sakai Takashi
Published: February 2024

There are not many reports on cervical spine alignment, and only a few analyze ideal surgical approaches and optimal amounts of correction needed for the various types of deformity. We comprehensively reviewed the present literature on cervical spinal deformities (with or without myelopathy) and their surgical management to provide a framework for surgical planning. A general assessment of the parameters actually in use and correlations between cervical and thoracolumbar spine alignment are provided. We also analyzed posterior, anterior, and combined cervical surgical approaches and indications for the associated techniques of laminoplasty, laminectomy and fusion, and anterior cervical discectomy and fusion. Finally, on the basis of the NDI, SF-36, VAS, and mJOA questionnaires, we fully evaluated the outcomes and measures of postoperative health-related quality of life. We found the need for additional prospective studies to further enhance our understanding of the importance of cervical alignment when assessing and treating cervical deformities with or without myelopathy. Future studies need to focus on correlations between cervical alignment parameters, disability scores, and myelopathy outcomes. Through this comprehensive literature review, we offer guidance on practical and important points of surgical technique, cervical alignment, and goals surgeons can meet to improve symptoms in all patients.
Patient Experiences and Challenges in the Management of Autoinflammatory Diseases—Data from the International FMF & AID Global Association Survey
Authors: Rech Jürgen , Schett Georg , Tufan Abdurrahman , Kuemmerle-Deschner Jasmin B. , Özen Seza , Tascilar Koray , Geck Leonie , Krickau Tobias , Cohen Ellen , Welzel Tatjana , Kuehn Marcus , Vetterli Malena
Published: February 2024

Background: Autoinflammatory diseases (AIDs) are rare, mostly genetic diseases that affect the innate immune system and are associated with inflammatory symptoms. Both paediatric and adult patients face daily challenges related to their disease, diagnosis and subsequent treatment. For this reason, a survey was developed in collaboration between the FMF & AID Global Association and the Erlangen Center for Periodic Systemic Autoinflammatory Diseases. Methods: The aim of the survey was to collect the personal assessment of affected patients with regard to their current status in terms of diagnostic timeframes, the interpretation of genetic tests, the number of misdiagnoses, and pain and fatigue despite treatment. Results: In total, data from 1043 AID patients (829 adults and 214 children/adolescents) from 52 countries were collected and analyzed. Familial Mediterranean fever (FMF) (521/50%) and Behçet’s disease (311/30%) were the most frequently reported diseases. The average time to diagnosis was 3 years for children/adolescents and 14 years for adults. Prior to the diagnosis of autoinflammatory disease, patients received several misdiagnoses, including psychosomatic disorders. The vast majority of patients reported that genetic testing was available (92%), but only 69% were tested. A total of 217 patients reported that no increase in acute-phase reactants was detected during their disease episodes. The intensity of pain and fatigue was measured in AID patients and found to be high. A total of 88% of respondents received treatment again, while 8% reported no treatment. Conclusions: AID patients, particularly adults, suffer from significant delays in diagnosis, misdiagnosis, and a variety of symptoms, including pain and fatigue. Based on the results presented, raising awareness of these diseases in the wider medical community is crucial to improving patient care and quality of life.
Moderate Intra-Abdominal Pressure Levels in Robot-Assisted Radical Prostatectomy Seem to Have No Negative Impact on Clinical Outcomes
Authors: Ippolito Angelo , Mulier Jan , Hahn Marta , Wenzel Mike , Mandel Philipp , Flinspach Armin N. , Wenger Katharina J.
Published: February 2024

Introduction: Radical prostatectomy is increasingly performed laparoscopically with robot assistance (RALRP). RALRP, as with all laparoscopic procedures, requires a pneumoperitoneum, which might result in peritoneal inflammatory response reactions and postoperative pain. The aim of this retrospective single-centre study was to analyse the effects of a pneumoperitoneum during RARLP on clinical outcomes. Methods: All patients who underwent robot-guided prostatectomy in our clinic were included, with the exception of patients who were converted to open prostatectomy. C-reactive protein was used as a marker for the primary outcome, namely the postoperative inflammatory response. Intra-abdominal pressure (IAP) was evaluated as a potential factor influencing inflammation. In addition, the waist–hip ratio was used to estimate the amount of visceral adipose tissue, and the administration of dexamethasone was considered as a factor influencing inflammation. The Visual Analogue Scale (VAS) was used to determine postoperative pain. Patients were consecutively recruited between 1 September 2020 and 31 March 2022. Results: A total of 135 consecutive patients were included. The median waist–hip ratio was 0.55. The median duration of the pneumoperitoneum was 143 min. The median values of the average and maximum IAP values were 10 mmHg and 15 mmHg, respectively. The mean CRP of the first postoperative day was 6.2 mg/dL. The median VAS pain level decreased from 2 to 1 from the first to the third postoperative day. On the first postoperative day, 16 patients complained of shoulder pain. In addition, 134 patients were given some form of opioid pain treatment following surgery. Conclusion: We could not identify any relevant associations between the duration and IAP of the pneumoperitoneum and the indirect markers of inflammation or indicators of pain, or between the latter and the amount of visceral adipose tissue. In addition, we found no significant effect of the administration of dexamethasone on postoperative inflammation. The results point to a noninferior tolerability of moderate pressure during the procedure compared to the commonly utilised higher pressure, yet this must be confirmed in randomised controlled trials.
Effect of Multi-Dose Dispensing on Medication Regimen Complexity: A Real-World Study
Authors: Lee Sunmin , Hahn Jongsung , Kim Heungjo , Chang Min Jung
Published: February 2024

(1) Background: Older patients frequently require dosing aids, such as multi-dose medication dispensing (MMD) when they experience medication regimen complexity (MRC) with increased drug use. However, the evaluations of the efficacy of MMD alterations remain limited. (2) Methods: A total of 1120 patients were included in the study who were discharged from hospital during the study period of January to March 2019. The Medication Regimen Complexity Index (MRCI) score, a validated 65-item tool in Korea (MRCI-K), was used to quantify MRC. The original MRCI-K scores, representing the typical administration based on prescription information, were compared to recalculated MRCI-K scores measured following MMD during the hospital dispensing period. Differences in MRCI-K across the top four wards based on the numbers of discharge prescription medications were assessed, and the overall scores were categorized into quartiles to identify MMD’s impact within each group. We confirmed the effect of MMD based on the patient’s admission diagnosis depending on MRCI. (3) Results: The mean (standard deviation) of original MRCI scores was 26.2 (13.4), which decreased to 18.9 (8.8) after applying MMD. The decrease in MRCI scores after MMD was statistically significant in all four wards, with the Orthopedic Surgery ward showing the biggest decrease. The patients with MRCI scores in the highest quartile group demonstrated the greatest improvement as a result of the implementation of MMD. Respiratory diseases exhibited the highest baseline MRCI scores due to formulation complexity, and ear, nose, and throat patients demonstrated the most significant reduction in MRC after MMD, depending on the diagnostic criteria at administration. (4) Conclusions: We confirmed the reduction in MRC after applying MMD, as a significant decrease in MRCI-K scores. This study highlights the need to deliver effective pharmacist-led services to identify patients who would benefit from MMD.
Atrial Fibrillation and Early Vascular Aging: Clinical Implications, Methodology Issues and Open Questions—A Review from the VascAgeNet COST Action
Authors: Pucci Giacomo , Grillo Andrea , Dalakleidi Kalliopi V. , Fraenkel Emil , Gkaliagkousi Eugenia , Golemati Spyretta , Guala Andrea , Hametner Bernhard , Lazaridis Antonios , Mayer Christopher C. , Mozos Ioana , Pereira Telmo , Veerasingam Dave , Terentes-Printzios Dimitrios , Agnoletti Davide
Published: February 2024

Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with adverse CV outcomes. Vascular aging (VA), which is defined as the progressive deterioration of arterial function and structure over a lifetime, is an independent predictor of both AF development and CV events. A timing identification and treatment of early VA has therefore the potential to reduce the risk of AF incidence and related CV events. A network of scientists and clinicians from the COST Action VascAgeNet identified five clinically and methodologically relevant questions regarding the relationship between AF and VA and conducted a narrative review of the literature to find potential answers. These are: (1) Are VA biomarkers associated with AF? (2) Does early VA predict AF occurrence better than chronological aging? (3) Is early VA a risk enhancer for the occurrence of CV events in AF patients? (4) Are devices measuring VA suitable to perform subclinical AF detection? (5) Does atrial-fibrillation-related rhythm irregularity have a negative impact on the measurement of vascular age? Results showed that VA is a powerful and independent predictor of AF incidence, however, its role as risk modifier for the occurrence of CV events in patients with AF is debatable. Limited and inconclusive data exist regarding the reliability of VA measurement in the presence of rhythm irregularities associated with AF. To date, no device is equipped with tools capable of detecting AF during VA measurements. This represents a missed opportunity to effectively perform CV prevention in people at high risk. Further advances are needed to fill knowledge gaps in this field.
Analysis of Strain Distribution in Common Clinical Designs of Posterior Implant-Supported Fixed Partial Restorations: Comparison between Six Configurations
Authors: Ghelfan Oded , Nissan Joseph , Shely Asaf , Ben-Izhack Gil , Chaushu Liat , Sharon Esi , Glikman Ari , Zenziper Eran , Rosner Ofir
Published: February 2024

The configuration of implant-supported prostheses is considered to influence the magnitude of stress concentrations, affecting their survival rate. The purpose of this study is to determine, through strain gauge measurements during load application, the dispersion and magnitude of strain concentrations in different implant-supported prosthesis designs. All designs matched those commonly used in posterior partially edentulous states. Three implants were inserted into an epoxy resin model (PLM-4B Vishay Measurements Group Inc., Raleigh, NC, USA), allowing for the delivery of three- and four-unit crowns in different cemented configurations. Loads were applied at vertical and oblique directions over the cast crowns in six different configurations representing various posterior partially edentulous restorations. The readings from the strain gauges adhered to the implant necks’ presented data on implant strain. Prostheses including cantilevers showed the highest strain among the three-unit prostheses within the prosthetic complex, and three single units showed the least (8133 µs vs. 201 µs, respectively). Angulated load application also had a role in amplifying the strains recorded, resulting in total strains of between 3.5 and 20 times higher than during vertical loading in all configurations. It can be concluded that the configuration of implant-fixed partial prosthesis changes the loads engaging the restoration, the implant, and, probably, the supporting bone.
Enhancing the Antifouling Properties of Alumina Nanoporous Membranes by GO/MOF Impregnated Polymer Coatings: In Vitro Studies
Authors: Moaness Mona , El-Sayed Sara A. M. , Beherei Hanan H. , Mabrouk Mostafa
Published: February 2024

Nanoporous membranes (NPMBs) have been the focus of interest of many scientists in the last decade. However, the fouling phenomenon that takes place during the implantation period blocks pores and causes failure in the local implant. In this study, alumina NPMBs were developed using electrochemical anodization through two steps. Furthermore, graphene oxide (GO), free and impregnated with ZIF-8 MOF, was synthesized and loaded in a mixture of PVDF/PVP polymer matrix at different ratios, and was applied to the produced NPMBs using spin-coater. The NPMBs were characterized before and after coating by SEM/EDX, TEM, FTIR, XRD, contact angle and AFM. The antifouling features of the NPMBs were analyzed against two different bacterial species. The prepared alumina NPMBs demonstrated homogeneous porous structures with pore sizes ranging from 36 to 39 nm. The coated layers were proven to possess microporous coatings on the surfaces of the NPMBs. The numbers of released ions (Al and Zn) from the coated NPMBs were below the allowed limits. Bovine serum albumin (BSA) uptake in artificial cerebrospinal fluid (ACSF) was impressively reduced with the presence of coating materials. In addition, the antifouling behavior of the coated NPMBs against the selected strains of bacteria was greatly enhanced compared with the pure alumina NPMBs. Finally, NPMBs’ uncoated and polymer-coated membranes were tested for their ability to deliver donepezil HCl. The results reveal the downregulation of donepezil release, especially from NPMBs coated with PVDF/PVP 0.5GO. It is advised to use the current antifouling materials and techniques to overcome the limitations of the inorganic NPMBs implants.
Influence of Hybrid Surface Modification on Biocompatibility and Physicochemical Properties of Ti-6Al-4V ELI Titanium
Authors: Woźniak Anna , Smok Weronika , Szewczenko Janusz , Staszuk Marcin , Chladek Grzegorz
Published: February 2024

Titanium-based materials are the most widely used materials in biomedical applications. However, according to literature findings, the degradation products of titanium have been associated with potential allergic reactions, inflammation, and bone resorption. The corrosion process of Ti-6Al-4V in the human body environment may be exacerbated by factors such as reduced pH levels and elevated concentrations of chloride compounds. Coatings made of biopolymers are gaining attention as they offer numerous advantages for enhancing implant functionality, including improved biocompatibility, bioactivity, wettability, drug release, and antibacterial activity. This study analyzes the physicochemical and electrochemical behavior of the Ti-6Al-4V ELI alloy subjected to PCL and PCL/TiO2 deposition by the electrospinning method. To characterize the polymer-based layer, tests of chemical and phase composition, as well as surface morphology investigations, were performed. Wetting angle tests were conducted as part of assessing the physicochemical properties. The samples were subjected to corrosion behavior analysis, which included open circuit potential measurements, potentiodynamic tests, and the electrochemical impedance spectroscopy method. Additionally, the quantification of released ions post the potentiodynamic test was carried out using the inductively coupled plasma atomic emission spectrometry (ICP–AES) method. Cytotoxicity tests were also performed. It was found that surface modification by depositing a polymer-based layer on the titanium substrate material using the electrospinning method provides improved corrosion behavior, and the samples exhibit non-toxic properties.
Ozone Application Suppressed the Blue Mold Development and Maintained the Main Active Ingredients Content of Postharvest Fresh Codonopsis pilosula during Storage
Authors: Chen Jiangyang , Liu Zhiguang , Liu Qili , Zhang Dan , Xue Huali , Shang Suqin , Bi Yang
Published: February 2024

Penicillium expansum is the predominant causal agent causing blue mold in postharvest fresh Codonopsis pilosula during storage. The pathogen reduces the yield and affects the quality of C. pilosula and even generates patulin, threatening human health. In this study, postharvest fresh, healthy C. pilosula was sprayed with P. expansum, and the control effect of ozone on postharvest diseases of C. pilosula was studied, and the effect of ozone on the contents in the main active ingredients of C. pilosula was compared; finally, the effect of ozone on reactive oxygen species (ROS) metabolism in C. pilosula was analyzed. The results showed that 2 mg L−1 ozone application significantly inhibited the occurrence of postharvest blue mold caused by P. expansum, reduced weight loss rate, controlled the accumulation of patulin and maintained the contents of the main active components in C. pilosula. The study will provide a theoretical basis for ozone treatment to control the occurrence of postharvest diseases of C. pilosula.
Preoperative Glycosylated Haemoglobin Screening to Identify Older Adult Patients with Undiagnosed Diabetes Mellitus—A Retrospective Cohort Study
Authors: van Wilpe Robert , van Zuylen Mark L. , Hermanides Jeroen , DeVries J. Hans , Preckel Benedikt , Hulst Abraham H.
Published: February 2024

More than 25% of older adults in Europe have diabetes mellitus. It is estimated that 45% of patients with diabetes are currently undiagnosed, which is a known risk factor for perioperative morbidity. We investigated whether routine HbA1c screening in older adult patients undergoing surgery would identify patients with undiagnosed diabetes. We included patients aged ≥65 years without a diagnosis of diabetes who visited the preoperative assessment clinic at the Amsterdam University Medical Center and underwent HbA1c screening within three months before surgery. Patients undergoing cardiac surgery were excluded. We assessed the prevalence of undiagnosed diabetes (defined as HbA1c ≥ 48 mmol·mol−1) and prediabetes (HbA1c 39–47 mmol·mol−1). Using a multivariate regression model, we analysed the ability of HbA1c to predict days alive and at home within 30 days after surgery. From January to December 2019, we screened 2015 patients ≥65 years at our clinic. Of these, 697 patients without a diagnosis of diabetes underwent HbA1c screening. The prevalence of undiagnosed diabetes and prediabetes was 3.7% (95%CI 2.5–5.4%) and 42.9% (95%CI 39.2–46.7%), respectively. Preoperative HbA1c was not associated with days alive and at home within 30 days after surgery. In conclusion, we identified a small number of patients with undiagnosed diabetes and a high prevalence of prediabetes based on preoperative HbA1c screening in a cohort of older adults undergoing non-cardiac surgery. The relevance of prediabetes in the perioperative setting is unclear. Screening for HbA1c in older adult patients undergoing non-cardiac surgery does not appear to help predict postoperative outcome.
Chromatin Remodeling-Related PRDM1 Increases Stomach Cancer Proliferation and Is Counteracted by Bromodomain Inhibitor
Authors: Hung Yu-Hsuan , Wang Hui-Ching , Pan Mei-Ren , Chen Li-Tzong
Published: February 2024

Gastrointestinal (GI) cancers are some of the main public health threats to the world. Even though surgery, chemotherapy, and targeted therapy are available for their treatments, these approaches provide limited success in reducing mortality, making the identification of additional therapeutic targets mandatory. Chromatin remodeling in cancer has long been studied and related therapeutics are widely used, although less is known about factors with prognostic and therapeutic potential in such areas as gastrointestinal cancers. Through applying systematic bioinformatic analysis, we determined that out of 31 chromatin remodeling factors in six gastrointestinal cancers, only PR/SET domain 1 (PRDM1) showed both expression alteration and prognosis prediction. Analyses on pathways, therapies, and mediators showed that cell cycle, bromodomain inhibitor IBET151, and BET protein BRD4 were, respectively involved in PRDM1-high stomach cancer, while cell line experiments validated that PRDM1 knockdown in human stomach cancer cell line SNU-1 decreased its proliferation, BRD4 expression, and responsiveness to IBET151; accordingly, these results indicate the contribution by PRDM1 in stomach cancer formation and its association with BRD4 modulation as well as BET inhibitor treatment.
The Omics Complexity in Sepsis: The Limits of the Personalized Medicine Approach
Authors: Isac Sebastian , Isac Teodora , Tanasescu Maria Daniela , Pavel Bogdan , Andreescu Cristina Veronica , Badea Andrada-Georgiana , Ojog Damiana , Teodorescu Geani-Danut , Laceanu Anca , Trifan Cristian-Bogdan , Droc Gabriela
Published: February 2024

Sepsis is one of the most common causes of morbidity and mortality worldwide. Despite the remarkable advances in modern medicine throughout the last century, the mortality rates associated with sepsis have remained significantly elevated, both in high- and low-income countries. The main difficulty in the diagnosis and treatment of septic patients is the tremendous heterogeneity of this condition. The vast heterogeneity that characterizes sepsis ranges from the clinical presentation to the biological aspects of the disease. Evidence-based medicine approaches sepsis as a homogenous syndrome and does not consider the individual discrepancies between septic patients. This approach may contribute to the poor outcomes of septic patients. In recent years, personalized medicine has gained significant interest. This novel form of medicine underlines the importance of understanding the genetic, epigenetic, and molecular basis of a disease in order to provide a more tailored approach for the patient. The study of “omics”, such as cytomics, genomics, epigenomics, transcriptomics, proteomics, and metabolomics, provides a deeper comprehension of the complex interactions between the host, the disease, and the environment. The aim of this review is to summarize the potential role of a personalized approach in sepsis management, considering the interactions between various “omics”.
Testing of Portfolio Optimization by Timor-Leste Portfolio Investment Strategy on the Stock Market
Authors: Anuno Fernando , Madaleno Mara , Vieira Elisabete
Published: February 2024

An efficient and effective portfolio provides maximum return potential with minimum risk by choosing an optimal balance among assets. Therefore, the objective of this study is to analyze the performance of optimized portfolios in minimizing risk and achieving maximum returns in the dynamics of Timor-Leste’s equity portfolio in the international capital market for the period from January 2006 to December 2019. The empirical findings of this study indicate that the correlation matrix showed that JPM has a very strong positive correlation with one of the twenty assets, namely BAC (0.80). Moreover, the optimal portfolio of the twenty stocks exceeding 10% consists of four consecutive stocks, namely DGE.L (10.69%), NSRGY (10.37%), JPM (10.04%), and T (10.03%). In addition, the minimum portfolio consists of two stocks with a minimum variance of more than 10%, namely SAP.DE (11.20%) and DGE.L (10.39%). The evaluation of the optimal portfolio using Markowitz parameters also showed that the highest expected return and the lowest risk were 1.22% and 3.12%, respectively.
Daco-Romanian Definite DPs at the Syntax-Phonology Interface
Authors: Isac Daniela
Published: February 2024

In this paper I propose that the host of the definite suffix in Daco-Romanian languages like Modern Romanian, Old Romanian, Megleno-Romanian, Istro-Romanian, and Aromanian (DacRom) is determined at PF, as a consequence of the conditions that apply to the Spell-Out of chains. The relevant chains are the result of an Agree relation obtained between the [def] feature of the D head and a matching feature of other heads within the DP, such as N and A. I propose that Agree chains are subject to restrictions that are similar to those affecting movement chains, so no new mechanisms need to be posited in order to account for the overt realization of the suffixal definite article in DacRom.
Evidence of Heritability in Prebiotically Realistic Membrane-Bound Systems
Authors: Sokolskyi Tymofii , Ganju Pavani , Montgomery-Taylor Ronan , Baum David A.
Published: February 2024

The vesicles of short chain amphiphiles have been demonstrated to grow and divide. Here, we explored whether vesicle populations show evidence of heritability. We prepared 1:1 decanoic acid:decylamine vesicles with or without a detergent and in either water or prebiotic soup, a mixture of compounds that might have been present on early Earth. The mixtures were subjected to transfer with dilution, where, after 24 h of incubation (one generation), we transferred 10% of the mix into a 90% volume of a fresh vesicle-containing solution. This was continued for 30 generations. Samples with a history of transfers were compared to no-transfer controls (NTCs), initiated each generation using the same solutions but without 10% of the prior generation. We compared the vesicle size distribution and chemical composition of the transfer samples and NTCs and compared their fluorescence signals in the presence of Nile Red dye. We observe changes in the vesicle size but did not detect differences in the chemical composition. In the samples with detergent and soup, we observed irregular changes in the Nile Red fluorescence, with a tendency for parent and offspring samples to have correlated values, suggestive of heritability. This last result, combined with evidence of temporal autocorrelation across generations, suggests the possibility that vesicles could respond to selection.
Identification of Fusarium oxysporum Causing Leaf Blight on Dendrobium chrysotoxum in Yunnan Province, China
Authors: Yang Jun , Ahmed Waqar , Zhang Jinhao , Gao Shunyu , Wang Zhenji , Yang Haiyan , Bai Xuehui , Luo Kai , Xu Chengdong , Ji Guanghai
Published: February 2024

Leaf-blight disease caused by the Fusarium oxysporum is an emerging problem in Dendrobium chrysotoxum production in China. Symptoms of leaf blight were observed on seedlings of D. chrysotoxum cultivated in a nursery in Ruili City, Yunnan Province, China. In this study, we isolated the Fusarium sp. associated with leaf-blight disease of D. chrysotoxum from the diseased seedlings. A pathogenicity test was performed to fulfill Koch’s postulates to confirm the pathogenicity of isolated strains and identified using morphological and molecular techniques. The results revealed that all four isolated Fusarium sp. isolates (DHRL-01~04) produced typical blight symptoms followed by marginal necrosis of leaves on the D. chrysotoxum plants. On the PDA medium, the fungal colony appeared as a white to purplish color with cottony mycelium growth. Microconidia are oval-shaped, whereas macroconidia are sickle-shaped, tapering at both ends with 2–4 septations. The phylogenetic trees were construed based on internal transcribed spacer (ITS), translation elongation factor (EF-1α), and RNA polymerase subunit genes RPB1 and RPB2 genes, respectively, and blasted against the NCBI database for species confirmation. Based on the NCBI database’s blast results, the isolates showed that more than 99% identify with Fusarium oxysporum. To our knowledge, this is the first comprehensive report on the identification of Fusarium oxysporum as the causal agent of Dendrobium chrysotoxum leaf blight in Yunnan Province, China, based on morphological and molecular characteristics.
Collocation Technique Based on Chebyshev Polynomials to Solve Emden–Fowler-Type Singular Boundary Value Problems with Derivative Dependence
Authors: Kumari Shabanam , Singh Arvind Kumar , Gupta Utsav
Published: February 2024

In this work, an innovative technique is presented to solve Emden–Fowler-type singular boundary value problems (SBVPs) with derivative dependence. These types of problems have significant applications in applied mathematics and astrophysics. Initially, the differential equation is transformed into a Fredholm integral equation, which is then converted into a system of nonlinear equations using the collocation technique based on Chebyshev polynomials. Subsequently, an iterative numerical approach, such as Newton’s method, is employed on the system of nonlinear equations to obtain an approximate solution. Error analysis is included to assess the accuracy of the obtained solutions and provide insights into the reliability of the numerical results. Furthermore, we graphically compare the residual errors of the current method to the previously established method for various examples.
RHCA: Robust HCA via Consistent Revoting
Authors: Zhang Zijian , Feng Kaiyu , Chen Xi , Liu Xuyang , Sun Haibo
Published: February 2024

Since the emergence of blockchain, how to improve its transaction throughput and reduce transaction latency has always been an important issue. Hostuff has introduced a pipeline mechanism and combined it with a chain structure to improve the performance of blockchain networks. HCA has introduced a revoting mechanism on the basis of Hostuff, further reducing transaction latency, but it has also brought some problems. In HCA, if the leader is malicious, it would be possible to continuously call on the replica nodes to revote, which can lead to network congestion. This paper employs the global perfect coin technology to guarantee that every replica can obtain a globally consistent and the freshest candidate proposal during the Revote phase, thereby improving the robustness of the HCA protocol. The performance improvement of RHCA in attack scenarios has been verified through experiments.
Design of a Novel Chaotic Horse Herd Optimizer and Application to MPPT for Optimal Performance of Stand-Alone Solar PV Water Pumping Systems
Authors: Abbassi Rabeh , Saidi Salem
Published: February 2024

A significant part of agricultural farms in the Kingdom of Saudi Arabia (KSA) are in off-grid sites where there is a lack of sufficient water supply despite its availability from groundwater resources in several regions of the country. Since abundant agricultural production is mainly dependent on water, farmers are forced to pump water using diesel generators. This investigation deals with the increase in the effectiveness of a solar photovoltaic water pumping system (SPVWPS). It investigated, from a distinct perspective, the nonlinear behavior of photovoltaic modules that affects the induction motor-pump because of the repeated transitions between the current and the voltage. A new chaotic Horse Herd Optimization (CHHO)-based Maximum Power Point Tracking technique (MPPT) is proposed. This algorithm integrates the capabilities of chaotic search methods to solve the model with a boost converter to maximize power harvest while managing the nonlinear and unpredictable dynamical loads. The analytical modeling for the proposed SPVWPS components and the implemented control strategies of the optimal duty cycle of the DC–DC chopper duty cycle and the Direct Torque Control (DTC) of the Induction Motor (IM) has been conducted. Otherwise, the discussions and evaluations of the proposed model performance in guaranteeing the maximum water flow rate and the operation at MPP of the SPVWPS under partial shading conditions (PSC) and changing weather conditions have been carried out. A comparative study with competitive algorithms was conducted, and the proposed control system’s accuracy and its significant appropriateness to improve the tracking ability for SPVWPS application have been proven in steady and dynamic operating climates and PSC conditions.
Toward Optimal Fitting Parameters for Multi-Exponential DWI Image Analysis of the Human Kidney: A Simulation Study Comparing Different Fitting Algorithms
Authors: Jasse Jonas , Wittsack Hans-Joerg , Thiel Thomas Andreas , Zukovs Romans , Valentin Birte , Antoch Gerald , Ljimani Alexandra
Published: February 2024

In DWI, multi-exponential signal analysis can be used to determine signal underlying diffusion components. However, the approach is very complex due to the inherent low SNR, the limited number of signal decay data points, and the absence of appropriate acquisition parameters and standardized analysis methods. Within the scope of this work, different methods for multi-exponential analysis of the diffusion signal in the kidney were compared. To assess the impact of fitting parameters, a simulation was conducted comparing the free non-negative (NNLS) and rigid non-linear least square (NLLS) fitting methods. The simulation demonstrated improved accuracy for NNLS in combination with area-under-curve estimation. Furthermore, the accuracy and stability of the results were further enhanced utilizing optimized parameters, namely 350 logarithmically spaced diffusion coefficients within [0.7, 300] × 10−3 mm2/s and a minimal SNR of 100. The NNLS approach shows an improvement over the rigid NLLS method. This becomes apparent not only in terms of accuracy and omitting prior knowledge, but also in better representation of renal tissue physiology. By employing the determined fitting parameters, it is expected that more stable and reliable results for diffusion imaging in the kidney can be achieved. This might enable more accurate DWI results for clinical utilization.
Single Machine Scheduling Proportionally Deteriorating Jobs with Ready Times Subject to the Total Weighted Completion Time Minimization
Authors: Lv Zheng-Guo , Zhang Li-Han , Wang Xiao-Yuan , Wang Ji-Bo
Published: February 2024

In this paper, we investigate a single machine scheduling problem with a proportional job deterioration. Under release times (dates) of jobs, the objective is to minimize the total weighted completion time. For the general condition, some dominance properties, a lower bound and an upper bound are given, then a branch-and-bound algorithm is proposed. In addition, some meta-heuristic algorithms (including the tabu search (TS), simulated annealing (SA) and heuristic (NEH) algorithms) are proposed. Finally, experimental results are provided to compare the branch-and-bound algorithm and another three algorithms, which indicate that the branch-and-bound algorithm can solve instances of 40 jobs within a reasonable time and that the NEH and SA are more accurate than the TS.