bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical case of unintentional overdose of paracetamol
Authors: Konovalova N.V. , Stopinchuk O.V. , Mazur Y.P. , Goncharov O.L.
Published: May 2020

Annotation. Paracetamol — an inexpensive effective and convenient analgesic — the first choice drug for the treatment of acute and chronic pain, an effective antipyretic, which is in the top sales in the US and Europe. Paracetamol is considered to be a safer drug than non-steroidal anti-inflammatory drugs, especially in terms of the risk of kidney, gastrointestinal and asthma/bronchial obstruction, even in high-risk patients (elderly, children and pregnant women). On the other hand, increased use of the drug in recent years has raised concerns about its hepatotoxicity. In fact, paracetamol-induced liver lesions are among the leading causes of acute liver failure. The purpose of the work is to demonstrate the importance of a detailed medical history analysis in individuals with suspected liver toxicity using a case study. In the article on the example of a clinical case of unintentional overdose of paracetamol the mechanisms of development of hepatotoxicity of the drug are presented, risk factors, clinic of overdose and principles of treatment are considered. The importance of detailed collection of medical history in individuals with suspected liver toxicity is indicated. The short list of different dosage forms of paracetamol in the pharmaceutical market is given. Significant danger of the combined forms of the drug for relieving the symptoms of colds, the lack of knowledge of patients regarding the constituents of such drugs and the variety of doses of paracetamol in such agents were emphasized. It is concluded that it is advisable to limit the use of high-dose (more than 325 mg) forms of paracetamol. Such a reduction in the amount of paracetamol per unit dose will reduce the risk of serious liver damage from unintended overdose.
Peculiarities of psychological support of patients with muscular-joint dysfunction of the temporomandibular joint
Authors: Kostiuk T.M.
Published: May 2020

Annotation. The pathology of the temporomandibular joint (TMJ) is one of the most difficult in the practice of the dentist, so patients go to different doctors. Often, the disease is psychosomatic, so patients have a history of stress, sleep disorders, headaches, chronic fatigue. The aim of the study is to study and comparatively analyze the nature and extent of psychological manifestations in patients with dysfunction of the temporomandibular joint according to the degree of clinical manifestations of the pathology irritability. In total, we examined 834 people with CNS dysfunction who had different etiologic causes, different complaints, and different clinical manifestations. To assess the psychological status of patients used: Gissen somatic complaints questionnaire, Toronto alexithymic scale, the method of studying the type of attitude to the disease Tobol, projective methodology “I am healthy and I am sick”, modified 10-point FPS-R (Bayers-based) subjective pain analysis scale. It was found that in the group of patients with pathology of the TMJ, the main complaint was pain (77.1%), the type of attitude to the disease is mainly alarming (59.5%), and the level of alexithymia is high (78%). Based on the received data on the general condition of the patient, they form a plan of providing comprehensive medical and psychological care, in which during the basic treatment psycho-corrective measures are combined with psychoprophylaxis of secondary disorders of the psychological health of patients.
Levels of toll-like receptors 2 and 4 in serum of men with postinfarction cardiosclerosis and its relationship with antiphospholipid syndrome components
Authors: Nazarova M.S. , Stanislavchuk M.A. , Burdeina L.V.
Published: May 2020

Annotation. There is a tendency for an increase of incidence of coronary heart disease (CHD) among young people, with the development of acute myocardial infarction (MI) in the absence of marked atherosclerosis and obstruction of the coronary arteries. Antiphospholipid syndrome (APS), cellular and humoral mediators of immunoinflammatory activation of endothelium are considered as factors of non-obstructive damage to the coronary vessels. New trigger factors for endothelial dysfunction, cardiac fibrosis, and myocardial hypertrophy include toll-like receptors (TLR2 and TLR4). Antiphospholipid antibodies may act as endogenous activators of toll-like receptors. The study of the association between APS components and expression of toll-like receptors in patients with CHD with postinfarction cardiosclerosis remains relevant. The aim is to study the levels of TLR2 and TLR4 and its relationship with APS components in men with postinfarction cardiosclerosis. 164 patients with stable CHD with postinfarction cardiosclerosis (100% of men, age 53.0±9.14 years) and 48 men of control group (without CHD) were examined. Levels of total antiphospholipid antibodies (aPL), antibodies to β2-glycoprotein 1 (anti-β2-GP 1) IgG and IgM, TLR2, TLR4 in serum were determined by ELISA. The studies were conducted in compliance with bioethical standards. Statistical processing of the results was performed in SPSS Statistics 22.0. Determined that men with postinfarction cardiosclerosis showed higher levels of TLR2 and TLR4 (in 1.8–2.2 times, p<0.001) in serum than control group. Higher (in 1.2–1.4 times) levels of TLR2 and TLR4 were found in patients who underwent Q-MI, recurrent MI and had clinical manifestations of APS (stroke, transient ischemic attacks, livedo reticularis). An increase TLR2 and TLR4 levels was closely associated with an increase of aPL and anti-β2-GP 1 of IgG (r = | 0.31 - 0.51 |, p<0.01). Thus, in men with postinfarction cardiosclerosis who had aPL and anti-β2-GP 1 IgG positivity had an unfavorable immunoinflammatory pattern, that characterized by increased expression of TLR2 and TLR4. The imbalance in TLR2 and TLR4 is more pronounced in young CHD patients and associated with Q-MI and recurrent MI.
Daily interleukin-1β variability in women with rheumatoid arthritis associated with fibromyalgia
Authors: Perebetyuk L.S. , Moroz L.V. , Shevchuk S.V. , Segeda Y.S. , Shtatko O.E.
Published: May 2020

Annotation. Disorders of circadian rhythms are considered to be one of the factors associated with the development of joint diseases. In patients with rheumatoid arthritis (RA) disorders of the neurohumoral regulation of circadian rhythms is a factor in the increased production of inflammatory cytokines in the joint tissues. In 30 % of RA patients, concomitant fibromyalgia (FM) is found, in which disorders of circadian regulation can deepen. Circadian features of the production of pain mediators and inflammation in RA patients with comorbid fibromyalgia (FM) have not been established. The aim of this study was to investigate the daily variability of serum interleukin-1β levels in RA patients depending on the comorbidity of FM. Materials and methods: 49 patients with rheumatoid arthritis (RA) (100 % female) aged 46.8 (39–53) years, with moderate and high disease activity (DAS28>3.2), of which 21 (42.9 %) patients with concomitant fibromyalgia (FM). Diagnosis of RA was established by ACR/EULAR criteria (2010), FM was diagnosed by mACR 2010. Blood sampling was performed twice daily (at 08-00 and at 20-00), the level of IL-1β in the blood was determined by enzyme immunoassay. The studies were conducted according to bioethical standards. Statistical processing of the results was performed by SPSS Statistics 22.0. Results: In RA patients circadian fluctuations of IL-1β level in blood were registered. IL-1β levels (08-00) in the morning was higher (1.2–1.3 times) than in the evening (20-00). In the presence of comorbid FM, patients with RA had significant increase in evening and average daily levels of IL-1β (1.3–1.6 times) than in RA patients without FM. Daily fluctuations of IL-1β correlate with RA activity and the fibromyalgia scale. Conclusions: In RA patients disorders of the circadian production of proinflammatory IL-1β, which are exacerbated under FM conditions, were detected. Increasing evening production of IL-1β correlated with the prevalence of pain index in RA patients with FM. Thus, disorders of IL-1β circadian production in RA patients can be integrated into the mechanisms of central sensitization and FM development.
Glicised treatment of nonpsychotic mental disorders in combatants with comorbid hypertension
Authors: Ratsyborynska-Polyakova N. V. , Semenenko K. M.
Published: May 2020

Annotation. For the recent time, the problem of mental health of patients with hypertension has been repeatedly mentioned in scientific studies. The data confirm that in people who are suffering from high blood pressure, a number of non-psychotic mental disorders are often encountered, in which the treatment with Glicised is significant. Objective: investigate the effectiveness of Glicised treatment for the treatment of nonpsychotic mental disorders in participants in hostilities in the East of Ukraine with comorbid hypertension. On the basis of the Vinnytsia Regional Clinical Hospital of Veterans of War (VOCHVW), 56 respondents were examined, suffering from hypertension and having non-psychotic mental disorders. The main methods of research: clinical anamnestic, clinical and psychopathological, socio-demographic, psychodiagnostic, statistical. According to the results of this work, it was discovered that an important place in the treatment of non-psychotic mental disorders in participants in hostilities in the East of Ukraine with comorbid hypertension belongs to the naturopathic psychotropic drug Glicised. The drug shows antistress, stress-protective, nootropic action: normalizes the processes of excitation and inhibition in the central nervous system, increases mental performance (improves cognitive function, in particular the ability to perceive and memorize information), eliminates depressive disorders, increased irritability, aggressiveness, confidentiality, normalizes sleep. Thus, the timely application of Glicised will improve the effectiveness of the treatment of respondents. The treatment with Glicised provides high compliance and does not show a negative effect on the course of concomitant somatic pathology, which characterized it as a given drug with no side effects. The general observed effect in this direction was the improvement of working capacity and the psychological state of respondents, which was reflected in a decrease in the proportion of the existing problems of patients.
Features of rheoencephalography in children with primary mitral valve prolapse
Authors: Kuleshov A.V. , Bulat L.M. , Medrazhevskaya Y.A. , Malyk S.L. , Chigir I.V.
Published: May 2020

Annotation. Mitral valve prolapse (MVP), as a manifestation of connective tissue dysplasia, is of great interest in the field of medicine. It occupies an important place in the structure of diseases of the cardiovascular system, which is mainly due to its high incidence and possible complications. MVP is detected in almost 2–3% of the population. In addition, this pathology with a genetic predisposition is a manifestation of a connective tissue defect and is rare in newborns and at an early age, which characterizes it as a progressive disease. At the moment, the features of cerebral hemodynamics in children with MVP are not well understood. The aim of our study was to study cerebral hemodynamics in children with primary mitral valve prolapse using quantitative indicators of rheoencephalography (REG). The study included patients with primary MVP. Under our supervision, there were 106 children aged 13 to 17 years. The control group included 23 healthy children at the same age. All children underwent a REG with quantitative indicators. In children with MVP, there is a variability in the results of REG in the cerebral hemispheres. Vascular elasticity is significantly reduced due to anacrot time increase (p<0.001), which, in fact, is characteristic of the hypertonic type of blood flow (57.5%). It can be argued that in children there is a hypovolemic type of blood flow in the form of a decrease in the rheographic index relative to the control group (p<0.05). There is a tendency to vascular tone tension of all calibers according to the absence of statistically significant deviations of the corresponding indicators (dictrotic index and the ratio of the duration of the ascending phase to the duration of the entire pulse wave). The same picture is observed with venous blood flow, according to the values of the dystolic index in the carotid artery basin. In the basin of the vertebral artery there is a tendency to increase the tone of small vessels and venous vessels. Thus, in children with mitral valve prolapse, cerebral blood flow changes in the form of hypovolemia in the carotid artery basin and normovolemia in the vertebral artery basin according to REG parameters; in this group of children with MVP, there is a tendency to tension in the tone of blood vessels of all calibers according to the absence of statistically significant deviations of the corresponding indicators (dictrotic index and the ratio of the duration of the ascending phase to the duration of the entire pulse wave). Also, patients with MVP should be constantly monitored by narrow specialists (cardiologists, neurologists) for timely and adequate recovery.
Some age-related features of intrauterine infection in premature infants
Authors: Bulat L.M. , Pipa L.V. , Lisunets O.V. , Kurets О.О. , Gilyuk O.G.
Published: May 2020

Annotation. The protective forces of newborns born prematurely, with low body weight under conditions of infection, are not capable of an adequate response. The aim of our study was to study some of the features of premature infants with low birth weight at the background of intrauterine infection. The first group consisted of 67 stories of premature babies born with low birth weight (LBW) from 1500 to 2500 g and gestational age 32–35 weeks (average gestational age — 34±2 weeks). It was revealed that a feature of the temperature homeostasis of children of group I is the establishment and maintenance of a temperature gradient, that is, the difference between central and peripheral temperatures, which ranged from 1,100 C to 1,500 C at the age of 6–7 days. It was found that the dynamics of the temperature gradient in the neonatal period is very often depended on the presence of perinatal pathology, namely, hypoxic-ischemic damage to the central nervous system. The regularities of temperature homeostasis in children of the second group are characterized, which amounted to 27 newborns with gestational age 38–40 weeks of gestation, birth weight 2600–3200 g without a clinic of respiratory disorders and neurological symptoms. On the 4th–5th day after birth, these children were discharged home under the supervision of a family doctor. In group II children who, after 1.5–2.5 months, were admitted to the neonatal pathology department diagnosed with acute respiratory viral infections: acute rhinopharyngitis or bronchitis, the temperature gradient ranged from 2.100 С to 3.500 С. In children, an increase in central temperature or a decrease in peripheral temperature was observed. It was found that with effective treatment on days 4–6, the temperature gradient was always constant and amounted to 1.500 С to 1.700 С. To identify the cause of the disease in the I and II groups, studies of blood, mucus from the pharynx and nose, and secretions from the trachea were performed. For this, we used the method of polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA) and bacteriological methods of research. The effect of intrauterine infection, the colonization of pathogenic intestinal microflora was evaluated, a low Apgar score of 1 and 5, the presence of respiratory disorders, hyporeflexia, a decrease in thymus, leukocytosis of more than 10 thousand, leukopenia of less than 4 thousand, neutrophilia with a shift to the left, which are very dangerous, were taken into account for premature babies and require respiratory support, colonization of the intestines with bifidobacterium and the use of immunocorrective therapy (venoimun at a dose of 0.4 ml / kg every other day for 3–5 days), which gives good results for nursing preterm infants.
Comparative assessment of fetal blood flow and cardiac system status of pregnant women with mitral valve pathology
Authors: Dnistryanska A.P. , Konovalenko Yu. , Godlevskaya N.A. , Burtyak N.G. , Baida L.S.
Published: May 2020

Annotation. The aim of this work is to analyze the course of pregnancy in women with mitral pathology, the task is to identify preclinical criteria for worsening cardiovascular pathology that can lead to the development of complications of pregnancy and functioning of the fetal CVS, to evaluate the effectiveness of preventive measures. The article presents the analysis of changes in ultrasound characteristics of fetoplacental blood flow in women with mitral valve prolapse and mitral valve insufficiency, as well as cardiovascular status in these women. Statistical processing was performed by calculating Student coefficients (+) using the Microsoft Excel PC program. Doppler examination of fetal umbilical cord blood flow during pregnancy was studied. The correlation between the level of maternal blood flow compensation and pathological changes in the fetoplacental complex was established. As a result of our work, the prevalence of the disease was estimated. As of 2018, it was found that of the total number of extragenital pathology in 1676 pregnant women with CVSD; respectively for 2017 — 1699, for 2016 — 1925, 2015 — 1857 in the region. Of these, 331 (2018), 313 (2017), 326 (2016), 306 (2015) had mitral valve defects, including prolapse. A retrospective assessment of pregnancy and childbirth indicates the possibility of complications of pregnancy and childbirth. In the group of patients with mitral valve prolapse and mitral valve insufficiency, compared to the control group, they did not show significant changes in the dynamics of the Doppler metrics of cardiovascular pathology, which indicates the compensation of the cardiovascular system against the background of changes in the valve. At the same time, the tendency to decrease of CF in women with mitral valve prolapse and insufficiency of the mitral valve against the background of increasing pregnancy is revealed, indicates a violation of CVD adaptation to changes inherent in pregnancy, which provoke hemic and hemodynamic changes in the body, which will cause pregnancy and fetal status. FPC status in women with mitral valve prolapse and mitral valve insufficiency worsens in the third trimester of pregnancy, especially indicators such as the ratio of systolic volume ratio (SVR) to diastolic volume ratio (DVR) and IR. The administration of 40 mg of ƅ-blockers for a 2-week period improved the FPC, was safe and effective.
Antimicrobial polymers with immobilized active groups for use in medicine
Authors: Toropin V.M. , Murashevych B.V. , Kremenchutskyi H.M. , Stepanskyi D.O. , Maslak H.S. , Burmistrov K.S.
Published: May 2020

Annotation. Polymeric materials with immobilized active groups are widely used in medicine. Some of them have pronounced antimicrobial properties and, to a certain extent, are alternatives to antibiotics. The aim of this research is to study the properties of new polymeric materials with immobilized groups-donors of active chlorine and active oxygen. Polymers of the FIBAN brand in the form of staple fiber and non-woven fabric, which are convenient for the manufacture of dressings, have been used as carriers. A special technology has been developed for the chemical grafting of N-chlorosulfonamide and peroxycarboxylic functional groups on them. The synthesized materials retain appropriate physical and mechanical properties and are stable enough. The antimicrobial activity of these materials has been studied in vitro with the modified method of “agar plates”. It has been proven that all of them have powerful microbicidal properties, especially against S. aureus, which is extremely important, given that these microorganisms are one of the most common multi-resistant pathogens. The antimicrobial and wound healing activity of N-chlorosulfonamide material in vivo has been studied on artificially infected wounds of laboratory rats. The polymer has been used as a component of the sticky wound dressing. It has been found that the use of such dressings reduces the number of pathogenic staphylococci 4–10 times and accelerates reparative processes. Thus, the synthesized polymers with immobilized active groups are effective local antimicrobial agents and can be recommended as components of wound dressings. It is advisable to further study their hemostatic properties, subchronic and chronic toxicity, their effect on basic biochemical parameters, as well as the study of the chemical composition of the different environments that are processed with them.
The ways to improve the educational process while studying medical chemistry in modern conditions
Authors: Marchak T.V. , Smirnova O.V. , Melnyk A.V.
Published: May 2020

Annotation. Ukraine's entry into the world community is impossible without the modernization of the higher education system aimed to train specialists at the level of international requirements. The purpose of this research was to uncover the potential of the medical chemistry subject for the development of the medical student's personality, the acquisition of practical skills, and the formation of the chemical competence of the future doctors by improving the educational process. In 2019–2020 the new scheme of conducting workshops on certain topics of the discipline “Medical Chemistry” was proposed that involved combining two related workshops in a way that the first class would be purely theoretical and the second would give students practical skills on the topic. It was tested on 450 first-year medical students. The effectiveness of the application of the new method of workshops was evaluated on the basis of comparison of indices of differential credit in medical chemistry (absolute and qualitative success, average mark). Student's parametric t-test was used to estimate the intergroup difference, while at the same time the frequency of the change was estimated by the F Fisher criterion. The methodology presented in the research provides the means of improvement of skills and knowledge of the discipline “Medical Chemistry”, forms students’ interest to the subjects, ensures better learning of theoretical content, skills in usage of chemical vessels and equipment, critical thinking, evaluating the results obtained and making conclusions. Use of proposed learning scheme in 2019–2020 statistically did not show significant difference in the grades of students, who study a discipline “Medical Chemistry” compared to normal learning process. On the other hand, it recorded statistically reliable increase of 14,2% in the absolute grades of 1st year students compared to 2018–2019 results, which demonstrates the potential of its use in an educational process.
Differential diagnostics and treatment of post-operative dynamic ileus
Authors: Nepomnyaschy V.V.
Published: May 2020

Annotation. Diagnostics and treatment of patients with long-term existing intestinal paresis in post-operative period with the frequency from 3.5 to 75% is an actual problem of abdominal surgery. Functional violations of intestinal motility demanding conservative therapy can be in one of case the cause of prolonged paresis, in other case – complications of surgery itself or pathologic state appearing independently but demanding relaparotomy. The objective criteria of differential diagnostics of prolonged paresis and dynamic ileus as a consequence of complications demanding surgery are absent by now. Aim of the study — identification and determination of reliable diagnostic criteria of differential diagnostics of “prolonged paresis” and other complications demanding surgery in the way of relaparotomy. 52 patients of the main group with dynamic ileus and its causes confirmed by ultrasound were included into the study; 50 patients with diagnosed dynamic ileus by combination of clinical and radiological methods of study were included into the comparison group. The study demonstrated that ultrasound method is most significant in differential diagnostics of dynamic ileus and its causes. Radiological study is uninformative in early post-operative period as it is done in horizontal position and the abdomen in these terms contains free gas (relaparotomy, presence of drainages). The use of the suggested method in the main group allowed determination of the causes of prolonged paresis and indications for relaparotomy: in 9 (17.2%) patients BO was found on the 3-4th day, post-operative peritonitis — in 3 (5.7%) cases, interstitial abscess — in 1 (1.9%). In 38 (73%) cases dynamic ileus was resolved conservatively. In the comparison group BO was found in 8 (16%) patients on the 7th day, post-operative peritonitis — in 4 (8%) cases, in 5 (10%) cases of the comparison group relaparotomy was done in vain. Thus ultrasound method is the main diagnostic method in early post-operative period in patients with prolonged paresis with the help of which differential diagnostics of mechanical and dynamic ileus can be done and indications for relaparotomy in the given category of patients can be determined. Decrease of post-operative mortality from 6 to 0% was the result of ultrasound method.
Clinical diagnostics of the shoulder’s soft tissue injures
Authors: Sergienko R.O. , Satyshev M.M.
Published: May 2020

Annotation. Our study is based on data of 444 patients with clinically, MRI diagnosed and then arthroscopically proved diagnosis of the shoulder’s soft tissue injures. Used the following diagnostic tests: “typical pain localization”, shoulder blade rhythm disturbance, “apprehension”, front driver test, compression rotary test, rear driver test, impedance test Nir, Hawkins, weaknesses of withdrawal, weakness of external rotation, “lift off”, “belly press”, “false paralysis”. We have described the most informative and simple clinical tests. Sensitivity and specificity for each clinical test were calculated. Sensitivity and specificity of these tests are statistically adjusted. It has been found that for clinical diagnostics of damage to the anterior-lower lip of the shoulder joint is more diagnostically attractive is the anterior driver test; for diagnosis of damage to the upper lip of the shoulder joint — compression-rotation test, preference is given to the rear “driver test”; for the diagnosis of subacromial conflict syndrome — a combination of two tests: Hawkins test and impingement test; for diagnosis of lesions of the supraspinatus muscle — test of weakness of the abduction; underarm muscle — test of weakness of external rotation; for the diagnosis of total damage to the rotator cuff (RС) — test “falling” hand; the specificity of “belly press” test is higher than the specificity of “Lift off” test when it is impossible to get your hand behind your back. Thus, tests of characteristic localization of pain and disturbance of the shoulder bladder rhythm are sufficient to suspect the patient of the pathology of the shoulder joint complex itself.
The level of psychosocial stress and mental health state in sailors of long-distance voyages
Authors: Kosenko K.A.
Published: May 2020

Annotation. The purpose of the work is to study the level of psychosocial stress and mental health state in sailors of long-distance voyages, to determine the need to create system-specific measures for the protection of their mental health. During 2016–2019, 300 sailors of long-distance voyages were surveyed, including 200 merchant fleet representatives (110 crew members and 90 sailors) and 100 workers of passenger-carrying fleet of Ukraine (70 crew members and 30 sailors). All surveyed were male, citizens of Ukraine. The study involved the use of clinical psychopathological and psychodiagnostic methods. Revealed that among the surveyed in each group, at least one third of the people who were consulted by a doctor did not show signs of mental health disorder or maladaptation. Among the respondents with some manifestations of mental maladaptation of different severity and clinical filling, there were more representatives of crew members (the number of merchant fleet commanders was higher than the number of passenger-carrying fleet commanders - 53% vs. 45%), and among sailors of both fleets the number of such persons was approximately the same (37% vs. 40%). The highest number of persons with pronounced manifestations of mental maladaptation of the clinical level of severity was recorded among sailors of the passenger-carrying fleet (27%), while among commanders the number of such persons had no statistical difference (16% vs. 13%). Healthy individuals without signs of maladaptation did not feel the burden of stress; surveyed with maladaptive manifestations of donozological severity and content, had a moderate level of psychosocial stress; patients with severe psychopathological inclusions have a severe level of stress. Thus, the level of psychosocial stress has a significant impact on the formation of mental health disorders in sailors of long-distance voyages, which should be taken into account when developing specific measures of psychotherapy and psychoprophylaxis for this contingent.
Ways of ensuring optimum volumes of food production in Ukraine and their economic accessibility to the population
Authors: Rudavka S.I.
Published: May 2020

Annotation. The basis of food security for the country and its regions is to ensure optimal food production and economic affordability. The purpose of the article is to identify ways to increase the production of high quality food and to ensure economic accessibility to the population of Ukraine in the purchase of food. As the volume of production of the most important foodstuffs per person is low, it is essential to increase the volume of production of agricultural products and their processing, to ensure economic accessibility to the population in the purchase of foodstuffs, for which it is necessary to develop a long-term program of agro-industrial development in the country. complex, reform the agrarian sector of the economy, create a land service for the control of land resources and develop its structure: cr vine farms, farms, private farms and cooperatives, run a transparent market of agricultural land, where the owners, land owners must be citizens of Ukraine, to provide comprehensive state support to producers of the agricultural sector to ensure economic conditions of accessibility in public purchasing food.
Peculiarities of psychological status families with oncological patient at different stages of disease development
Authors: Krivonis T.
Published: May 2020

Annotation. Cancer affects not only the patient but also affects the functioning of the whole family. The purpose of the work is to identify the peculiarities of the psychological status of the family with the cancer patient at different stages of the disease. On the base of informed consent, 286 families of cancer patients examined: 174 families with patient-wife and 112 families with patient-husband. Families examined at different stages of the treatment process, namely, at the first episode of the disease — 78 women and 51 men, and after return of the disease or its relapse — 96 women and 63 men. The FACES-3 family adaptation and cohesion scale was used. It is established that in families with cancer patients found changes in family functioning caused by the disease, which expressed in the formation of a specific behaviour patterns, most often by type of excessive care. In patients with continued illness observed changes in behaviour model in form of excessive care or distancing which reflected in levels of cohesion and adaptation. Thus, changes in family functioning in families with a patient suffering from cancer necessitate the development of family-oriented medical-psychological help.
Molecular genetic mechanisms, human sex determination levels and disorders of sexual differentiation
Authors: Shevchuk T.I. , Khliestova S.S. , Horbatiuk S.M. , Vasenko T.B. , Sprut O.V.
Published: May 2020

Annotation. The purpose of this work — an analysis and a summary of results of scientific research on problems of molecular genetic mechanisms and human sex determination levels. Literature analysis was performed in scientometric databases of Google Scholar, MedLine, Web of Science, Scopus for 2014–2018. Sex determination is a complex multi-stage process secured by functional integration of genetic determinants, products thereof, and the conditions of individual development for its realization. Sexual differentiation occurs at genetic, gonadal, hormonal, somatic, psychological and social levels, and disorders at any of them may lead to deviations from normal sex determination.
Clinical-morphological study of lung diseases in basic treatment with the use of antioxidants of different origin and without
Authors: Korol T.M. , Ahafonov K.M.
Published: May 2020

Annotation. The purpose of the work is to analyze contemporary views on the morphological changes of lung tissue in inflammatory disease in the clinical and experimental conditions and results of correction by using the antioxidants. The analysis is based in a review if foreign articles for 2014-2019, using the scientometric databases PubMed, Web of Science and Google Scholar. According to the latest data from WHO and WORLD HEALTH RANKINGS 5-year mortality rate of such disease as COPD typically ranges from 40% to 70%, depending on disease severity, while the 2-year mortality rate for people with severe COPD is about 50%. We know that almost 90% of COPD deaths occur in low- and middle-income countries such as Ukraine. Thereby mortality rate from lung tissue diseases in Ukraine is 11.11%. These diseases often accompanied by inflammation and oxidative stress. The last can cause mitochondrial dysfunction, dynamic changes and mitophagy impairment, which leads to increase the number of superoxide anions, hydrogen peroxide etc., inflammatory responses and cellular senescence. They all play important roles in the pathogenesis of chronic lung diseases, such as chronic obstructive pulmonary disease, pulmonary fibrosis and bronchopulmonary dysplasia. Many studies in vitro approved the role of antioxidants in the decreasing of the degree of morphological changes: inflammatory cells infiltration and alveolar edema, permeability and inflammation. In vivo disease development is mainly related to the many conditions, but closely to its severity and possible of combination with other diseases. Thereby treatment of such diseases by using e.g. leaves extract of different herbs can be prescribe to ameliorate the level of reactive oxygen species and decrease the possible cell injure made by anti-inflammatory medicines.
Constitutional and psychological features of seborrheic dermatitis (analysis of scientific literature)
Authors: Khasawneh Ahmad Raed
Published: May 2020

Annotation. The purpose of the work is to analyze the scientific literature regarding the constitutional and psychological features of the occurrence and course of seborrheic dermatitis (SD). A review of the literature indicates that diabetes is a multifactorial disease with complex and multifaceted pathogenesis. The works of recent years reflect the involvement in the pathogenesis of SD of virtually all integrating systems of the organism and the main links of its basic functional systems. In the phenotypic manifestation of SD involved both exogenous (physico-chemical, biological) and endogenous (nervous system, genetic predisposition and immune disorders) factors. The pathogenetic mechanisms of dermatitis are polymorphic and do not contradict but complement each other. Studying the constitutional and psychological features of SD in Ukrainian residents is thus a promising area of research.
THE STATE OF HYGIENE AND LOCAL IMMUNITY OF THE ORAL CAVITY IN PATIENTS WITH ANOREXIA NERVOSA
Authors: M. Yu. Antonenko  , L. L. Reshetnyk  , E. V. Moskalenko  , N. A. Zelinska  , O. A. Znachkova
Published: May 2020

Aim: to study the state of local immunity and oral hygiene in patients with GP suffering from AN.Materials and methods: 35 patients with AN were examined at the age of 19-35 years. In the study we used immunological methods, an index assessment of the state of oral hygiene (PMA, API, GI).Results and discussion: in patients of I group poor oral hygiene was established. The amount of lysozyme in the oral fluid in I group was 0.014 ± 0.07 g/l. A decrease SIgA (11SIgA) was established in patients of I group: I, II and control (135.31 ± 23.17, 130.26 ± 24.21 and 300.34 ± 27.38 mg/l, respectively). A tendency to an increase in the level of IgG in the oral fluid in patients of group II compared with I and the control group (5.35 ± 0.36, vs. 4.57 ± 0.04 and 4.98 ± 0.23 g/l, respectively) was established.Conclusions: poor oral hygiene is an objective indicator which reflects low motivation to maintain oral health. The observed immunodeficiency (11SIgA) in patients with GP is a mirror image of changes occurring in the body of patients with AN.
TEACHING STAFF PROFESSIONAL DEVELOPMENT IN THE CONTEXT OF INCLUSIVE EDUCATION
Authors: Meline Grigoryan
Published: May 2020

The article deals with the issues of providing support to pedagogical team in the inclusive education settings as the main condition for the success of inclusion implementation. As a methodological basis for the analysis, the teacher competence structure is used as an approach. There are given many ways to expand the circle for teachers support. Arguments are also made in favor of engaging and interested in organizations for all employees of an inclusive school to create an inclusive team and the necessity for interest in joint work of both the administration and the teachers, correctional teachers included.
WINNICKI I BRACŁAWSKI ZAMKI W BADANIACH POLSKIEGO HISTORYKA ХІХ w. А. JABŁONOWSKIEGO
Authors: Nina Weselska
Published: May 2020

The materials of the castles' audits were carried out by the Polish government during the 16th – 17th centuries. In the fundamental edition «Źródła dziejowe» the Polish historian A. Yablonovsky analyzed the materials of the audits of the Volyn and Podolsk castles in the 16th century and made a general description of six Ukrainian castles.The article analyzes the materials of audits of Ukrainian Castle (Bracławski and Winnicki castle) and shows the features of their economic, defense, administrative-territorial structure, population, land relations. A.Yablonovski published materials contain historical facts for the analysis the administrative-territorial structure and socio-economic situation of the Bracławski and Winnicki Castles in the 16th – 17th centuries. Since most of the castles are completely or partially destroyed, historian research is now very important. This materials are important documents for the analysis some facts of the defense system and socio- economic situation of Ukrainian lands in this period.
ЕКОЛОГІЧНІ ТА ЕТИЧНІ КОНЦЕПЦІЇ В МОДНІЙ ІНДУСТРІЇ ТА ПРЕЗЕНТАЦІЙНИХ ПРОСТОРАХ ДЛЯ МОДНИХ ІННОВАЦІЙ
Authors: Квасниця Роксоляна
Published: May 2020

This article explores theoretical insights and practical tools to include sustainable practices in the design of innovative fashion show venues. An environmentally sound design of a fashion event venue is a complex and multifaceted process. It requires deep knowledge of ecological principles, calls for a synthesis of various scientific fields and a reasonable correlation between ecological, functional, aesthetic and economic factors. This article provides specific examples which highlight the effectiveness of the application of sustainable design principles. It also outlines some recommendations for the arrangement of fashion event venues.
THE ASSESSMENT OF THE INTERCONNECTION BETWEEN ECONOMIC GROWTH AND INFLATION IN THE REPUBLIC OF ARMENIA
Authors: Artur Karapet Ayrumyan
Published: May 2020

Considering the connection between inflation and real growth one should take into account the interruptions of time interactions. Thus, current GDP gap is likely to have a greater influence on the coming era. On account of that time-lag impacts of indicators should be studied.
INDICATORS OF ENDOTHELIAL DYSFUNCTION IN PREGNANT WOMEN WITH GESTATIONAL DIABETES MELLITUS
Authors: Avramenko T. V.  , Litvinov S. K.  , Malinina O. B.
Published: May 2020

The article presents the results of the discovery of violation of concentration of prostaglandins and endothelial factors in the blood of pregnant women with gestational diabetes, depending on the nature of the compensation of the disease.
PATHOMORPHOLOGICAL CHANGES IN RATS' RETINAL LAYERS AT THE END OF THE TWELFTH WEEK OF EXPERIMENTAL OPIOID INFLUENCE
Authors: Paltov E. V.  , Kovalyshyn O. A.  , Fik V. B.  , Kryvko Y. Ya.  , Podoliuk M. V.  , Holeyko M. V.
Published: May 2020

The goal in our work was to study the long-term effects of opioid analgesics in therapeutic doses on the structure of the retinal layers in chronic opioid influence. The goal was achieved by using the microscopic technique of visualizing the retinal layers of the eyeball of the rat. Microstructural preparations were prepared according to the generally accepted method using dyes, hematoxylin, eosin, and azan by the method of Heidenhain.As a result of the twelve-week experimental opioid effect, we discovered vacuated dystrophy and necrotic changes in the pigment epithelium, with the progression of the phenomenon of microcystoid degeneration of the outer mesh layer, and the increase in changes in the microcirculatory blood flow localized in the inner layers of the retina.The results of our experimental research in the future will allow us to form a pathomorphological basis, which can be used to perform a comparative characterization of the state of the layers of the retina and its the microcirculatory blood flow in normal range with experimental opioid effects at different terms of acute, subchronic and chronic opioid effects. Using the above information, we will be able to determine the optimal timing for correction in order to reduce and stabilize the pathomorphological manifestations of opioid effects on destructive changes in the layers of the retina and its the microcirculatory blood flow.
ДИНАМІКА МАРКЕРІВ ФІБРИНОЛІЗУ У ПАЦІЄНТІВ З ПІДВИЩЕНИМ ІНДЕКСОМ МАСИ ТІЛА ПРИ ПОЛІТРАВМІ
Authors: Кучерявченко В. В.  , Волкова Ю. В.  , Шарлай К. Ю.
Published: May 2020

The aim of our work was to analyze the dynamics of fibrinolysis markers in patients with an increased body mass index with polytrauma (IBMI). A study of complex hemostasiograms was carried out in 224 patients with IBMI during the month of hospital stay with a diagnosis of Polytrauma and on the 360th control day of the outpatient visit, which included the study of fibrinolysis indices: fibrinolysis (spontaneous) and soluble fibrin-monomeric complex (SFMK). Patients had the same severity at the time of admission on the APACHE II scale of 14 ± 5.8 and were divided into 3 clinical groups, depending on the starting BMI numbers. Thus, in patients with IBMI with polytrauma, dynamic disturbances in the fibrinolysis system were identified, which correspond to the course of the traumatic disease and significantly affect the functioning of the hemostasis system as a whole.
АКЦЕНТУАЦІЇ ХАРАКТЕРУ УЧНІВ ТА СТУДЕНТІВ СУЧАСНИХ НАВЧАЛЬНИХ ЗАКЛАДІВ РІЗНИХ ТИПІВ У КОНТЕКСТІ СТРЕСОСТІЙКОСТІ
Authors: Оксана Тимощук  , Володимир Дерпак  , Михайло Йонда  , Токар Ірина Тадеївна  , Кича Ірина Іванівна
Published: May 2020

This work shows relevance of research into stress resistance of students at modern educational establishments. It describes methods of studying personality accentuations by G. Shmishek, examines peculiarities of stress resistance, accentuations of character and the way they affect young people. It was established that the highest values of the indicators are found in boys and girls hyperthymic type, and the lowest ones are among both the young males and females of the dysthymic type. The gender and age diversities were observed in the following accentuations: cycloid type, demonstrative type, affective-exalted, anxious, emotive, excitable. Moreover, the values of the indicators were in all groups higher for girls than for boys. The work demonstrates that each person has a certain set of features which under certain conditions can be accentuated and determine significantly the human reaction. These qualities are especially vivid in adolescence due to the imperfection and vulnerability of the nervous system, the formation of character, the change of values, selectivity and vulnerability in relation to the environment, parents and friends. Therefore, the development of ways to correct accentuated character traits among students of modern educational institutions of different types is becoming relevant.
ONE PASTORAL POEM OF DAVIT GURAMISHVILI
Authors: Mzia Lazishvili
Published: May 2020

“The Book Cheerful Summer” of Georgian Writer, which is created by the pastoral theme of Davit Guramishvili, which echoes The Russian Folklore. The poem is a small genre and carries bucolic-pastoral characteristics. The author of the poem echoes the revival period of European-Russian pastoral theme, in addition, he has a moral character – who is the shepherd boy- Katsvia, who is grown up with Christian values, denying the familiar and eccentric relationships. In The poem there are conflicts between two worlds - carnival Life and traditional values. The first of them is the shepherd girl, the second one is the shepherd boy – Katsvia. This poem is considered as a writer's testament is a didactic and moral. At the same time, the author refuses in his dominant epoch on “the three styles theory” and the folk, where he appeals the simple narrate, the verification is original, the narrate is interesting and it is featured by the lightness of folklore and feminine expressions.
АВТОМАТИЗАЦИЯ БИЗНЕСА НА ОСНОВЕ CRM- СИСТЕМ
Authors: О. Н. Образцова  , О. М. Бакунова  , А. В. Мирошниченко  , М. В. Малюжич  , И. В. Михайловский  , П. П. Литвинко  , А. С. Иванов  , А. Н. Юрченко
Published: May 2020

Currently, the structure of corporate information systems stand out CRM-systems, allowing to automate customer relationships. As a result of scientific and practical research, the advantages and disadvantages of various CRM-platforms were analyzed and a number of software tools, that allow automating small and medium-sized businesses, were developed.
ТРЕБОВАНИЯ К РАЗРАБОТКЕ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ ДИСТАНЦИОННОГО БАНКОВСКОГО ОБСЛУЖИВАНИЯ
Authors: О. Н. Образцова  , О. М. Бакунова  , А. А. Гуринович  , Р. В. Левшунов  , С. В. Павлов  , В. Д. Дивин  , И. А. Шуба  , В. М. Светличный
Published: May 2020

The article discusses the benefits of implementing remote banking services, formulated the diverse requirements for remote banking software, in particular, requirements in terms of integration with banking systems, in terms of security and in terms of usability. Considering these requirements allows us to formulate a high-quality technical task for the development of software for remote banking services.
CHANGES IN CARBOHYDRATE METABOLISM IN PATIENTS WITH ALCOHOLIC CIRRHOSIS OF THE LIVER ASSOCIATED WITH NON-ALCOHOLIC FATTY LIVER DISEASE DEPENDING ON THE STAGE OF DECOMPENSATION
Authors: Nataliia Matkovska  , Nataliia Virstiuk  , Uliana Balan
Published: May 2020

The purpose of the research was to study the changes in adipocytokines in patients with alcoholic liver cirrhosis (ALC) associated with non- alcoholic fatty liver disease (NAFLD) depending on the stage of decompensation. A significant increase in immunoreactive insulin, the HOMA-IR index and a decrease in the QUICKI index in patients II gr. in comparison with patients I gr. has been detected, that indicating insulin resistance (p<0.05). On the basis of the results of the analysis of the correlation between the levels of leptin, adiponectin, resistin and carbohydrate metabolism, it was found that a stronger correlation was observed in patients suffering from ALC associated with NAFLD.
ХУДОЖНЯ РЕАЛІЗАЦІЯ КОНЦЕПТУ МАСКИ У РОМАНІ ЮРІЯ АНДРУХОВИЧА «ПЕРВЕРЗІЯ»
Authors: Підодвірна М. І.
Published: May 2020

The article deals with the concept of mask, which is realized in the novel by Yuri Andrukhovich «Perversia». The mask of the author, the mask of the narrator and the mask of the character and the peculiarities of their functioning in the fiction text are explored.