bluuebunny/crossref_metadata_2025 huggingface dataset:
Políticas públicas estatales en Colombia con enfoque basado en derechos humanos para el cumplimiento de la firma del entendimiento común ONU- 2003
Authors: Gutierrez Ossa Jahir Alexander
Published: September 2023

Se parte de la Firma del Entendimiento Común aprobada por la Organización de las Naciones Unidas en el año 2003 (ONU-2003), en la que en adelante las Políticas Públicas Estatales (Políticas y Programas) tendrían que reafirmarse desde el Enfoque Basado en los Derechos Humanos (EBDH) sin discriminación, excepción o jerarquías. La pregunta de investigación gira en torno a: ¿Cuáles son los alcances de la Firma del Entendimiento Común en las Políticas Públicas Estatales en Colombia desde el EBDH ONU-2003, de cara a las exigencias políticas y jurídicas que derivaría en su posible judicialización, para un país embarcado en un estado de cosas inconstitucionales? La Metódica está compuesta por el Funcionalismo Estructuralista, desde el que se asume que la sociedad siempre está expuesta a consideraciones complejas (problemas) y, que a partir de ellos se trata de avanzar, pero, son las propias situaciones problémicas las que activan el progreso de la sociedad y de los Estados al reconocer las dificultades. Se suma a la metódica, la Complejidad, compuestas por el análisis, dinámica y pensamiento complejo en laque se encuentran la teoría de la información, la teoría cibernética y la teoría sistémica como fuentes complejas y como paradigmas al análisis dialógico, de recursión y hologramático, que obligan, a que el Estado de respuestas constantemente, dado que, la población solicita soluciones constitucionales.
Market Integration among Major Wheat Markets in India
Authors: Udhayan N.  , Naik A. D. , Hiremath G. M.
Published: September 2023

The study is based on secondary data which tests the price movement and integration between major national wheat markets i.e. Lakhimpur, Agra, Vidisha, Dewas, Kota and Baran markets. Monthly wheat prices data of 15 years from 2007-08 to 2021-22 which was collected from www.agmarknet.gov.in. To analyze the market integration among major wheat markets, the Augmented Dickey-Fuller test, Johansen Co-integration test and Granger Causality test were applied with the help of E-views statistical package. The results indicated the strong market integration in terms of price linkages among major wheat markets. The results revealed that the major markets of wheat have strong price linkages and thus are spatially integrated. It could be seen that existence of mostly (10) unidirectional causality with few (3) bidirectional causality among selected wheat markets.  It was further revealed from the analysis that, any disturbance in price will get corrected in about 5 days in Lakhimpur market, 3 days in Agra market and 3 days in Kota market in short-run equilibrium. The transfer of price signals from one market to another helps in stabilizing the prices over space and create a healthy competitive environment. This would also help to protect the interest of producer-sellers. In order to achieve the goal of integration, the government should strengthen the market intelligence and communication within markets. The following study recommendations were made: a) Government should subsidize provide is transportation. b) Government and stakeholder should advise commercial banks to give low interest long-term loans to farmers because many impoverished farmers can't afford crop mechanization. c) Government and other i.e, NGO advertising should be increased to raise knowledge about improved agricultural machinery. d) Government and other i.e, NGO should educate farmers. Farmers can employ technology if they are trained and educated. They should also be told how much fertilizer to use so it yields more.
Public Service Innovation in Barru District, Indonesia: A Qualitative Investigation
Authors: Pananrangi Andi , Akib Haedar , Manda Darman , Gani Hamsu Abdul
Published: September 2023

Public policy as an instrument that seeks to synergize the role of government and public interest can be said to be currently not running optimally. The existence of policies that are canceled or revised by the government is an indication of overlapping policies and the low ability to innovate and willingness to innovate of public officials even though innovation. This study aims to analyze public service innovation in the Barru district. The type of research to be used is qualitative descriptive. The selection of this type is based on the aim of obtaining a complete and realistic description of service innovation. Research Findings that the innovation of improving administrative services has largely not met the expectations of the community. There are still various obstacles that need to be fixed so that the innovations carried out are truly of high quality and provide new hopes that can satisfy the public. It can be concluded that the innovation of improving administrative services has largely not met the expectations of the community. There are still various obstacles that need to be fixed so that the innovations carried out are truly of high quality and provide new hopes that can satisfy the public. Recommendations The era of digitalization that is growing rapidly in the field of Technology, Information, and Communication in the world today has an impact on the implementation of internet-based government or e-government at the central level to the local government level.
Regression Model Based on Thermal Indices and Heat Use Efficiency for Estimation of Pigeonpea (Cajanus cajan (L.) Millsp.) Seed Yield
Authors: Jaybhaye Pralhad , Nikam Saurabh
Published: September 2023

A field experiment was conducted on experimental farm of Dept. of Agricultural Meteorology, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani, Maharasthra, India during the during kharif season 2015 under rainfed condition to find the relationship of pheno thermal and heat use efficiency indices with yield. The field experiment was laid out in factorial randomized bock design with five sowing dates (i.e. 25th, 26th, 27th, 28th and 29th SMW) and three varieties (viz., BDN-711, BSMR-736 and BSMR-853) with three replications. The sowing dates significantly influenced on the phenology, growth, development and yield attributes. The dry spell experienced during sowing to emergence period in first sowing date (25th SMW sowing) and thereafter no rainfall condition during remaining period of sowings viz., 26th, 27th, 28th and 29th SMW, therefore, emergence and final plant count was observed lowest in 25th SMW (30 and 29 %) and highest in 27th SMW sowing (92 %). Hence, significantly highest dry matter plant-1, no. of pods plant-1, seed weight and seed yield plant-1 was observed in 25th SMW sowing; seed yield (417.7 kg ha-1), seed yield heat use efficiency (0.20 kg ha-1 0C day-1) was recorded highest in 27th SMW sowing and lowest in 25th SMW sowing. Significantly highest no. of pods plant-1, seed weight and seed yield plant-1, seed yield heat use efficiency, pheno thermal index was observed in BDN-711 variety and significantly lowest in BSMR-853 variety.  The significantly highest total dry matter plant-1 was observed in BSMR-853 and lowest in BDN-711 variety. Significantly highest GDD, HTU and PTU required for completion of different phenophases were recorded in BSMR-736 variety and significantly lowest in BDN-711 variety. Weather indices viz., GDD, HTU, PTU, PTI showed non-significant correlation at all the phenophases with seed yield of pigeonpea. The yield prediction model based on thermal indices and seed yield heat use efficiency at floral bud initiation to 50 % flowering and at 50 % flowering to 50 % pod formation phenophases was found useful in assessing the crop yield one and half to one month in advance.
Assessing Asian Elephant Habitat Preferences in the Central Western Ghats Using GIS, Remote Sensing, and Analytical Hierarchy Process (AHP)
Authors: Kumar Vipul , Raghevendra S. , Devagiri G. M. , Rani Vanita
Published: September 2023

Geographic Information Systems (GIS) and remote sensing are geospatial technologies that have been widely utilized in environmental science for decades, including data collecting and analysis on animal physical disability, wilderness modeling, and site assessment. Remote sensing technology has been employed in the present investigation. GIS and Analytical Hierarchy Process (AHP) methods were used to assess the habitat preferences of Asian elephants. Use satellite imagery and topographic maps to create environments and habitats, including land use cover (LULC), static vegetation (Normalized Difference Vegetation Index), water, Digital Elevation models (DEM), line and aspect. Next comes the use of AHP to determine the location, select the location's priority and distribution pattern. This study examined the habitat preferences of Asian elephants in the Shakleshpur Taluk in the Central Western Ghats in the Karnataka district of Hassan.The results show that 16 percent of the land and 18 percent of the population is covered with forests. Most places have an altitude of 25° to 40° and an altitude of 800 m and 1000 m. The amount of water in the region is limited to the habitat of the elephants. Habitats inhabited by elephants highlight the need for good management inside and outside protected areas to protect these elephants, especially in areas of translocation, to ensure that habitats are compatible. This information will be useful to people working to safeguard Asian elephants and their surroundings in the Western Ghats.
Evaluation of Response of Different Varieties of Major Crops for Organic Farming under North Gujarat Condition
Authors: Desai L. J.  , Patel K. M.  , Patel P. K.  , Patel V. K.  , Patel R. R.
Published: September 2023

A field experiment was conducted during 2015-16 to 2021-22 at Centre for Research on IFS, S.D.A.U., Sardarkrushinagarto study the evaluation of response of different varieties of major crops for organic farming under north Gujarat condition. Total eight different varieties of each crop groundnut, wheat and green gram were taken for study during the kharif, rabi and summer season, respectively. The experiment was laid down in randomized block design with three replications. Significantly higher groundnut pod yield (1813 kg/ha) and haulm yield (2755 kg/ha) were recorded in GJG 17 (S) in pooled results and also in individual years. The significantly higher groundnut equivalent yield (2115 kg/ha), economic performance in terms of net return (82404 ₹/ha) was recorded higher in case of GJG 17 (S) as compare to other variety. In case of wheat variety, significantly higher groundnut equivalent yield (1850 kg/ha), gross return (1,18,047 ₹/ha) and net return (50,239 ₹/ha)) was recorded under GW 451, which was at par with GW 496 wheat variety. During summer season, significantly highest groundnut equivalent yield (612 kg/ha), gross return (39031 ₹/ha) and net return (9730 ₹/ha) were recorded with greengram variety GM4. There was improvement in soil nutrients status over its initial value by using the organic manure in cropping system. The percent increase in soil organic carbon was 32.6%, available nitrogen 17.3%, available phosphorus 78.9%, available potassium 5.8%.,while 21% increase in water holding capacity and 4.3% reduction in bulk density due to continuous use of organic manures as a sources. The bacterial population, actinomycetes and fungi population were increased over first year after conversion period and recorded higher in last year 2021-22 under groundnut-wheat- greengram crop sequence.
Impact of Manufacturing Errors on Tooth Surface Forces in RV Reducer Cycloid Pinwheels
Authors: Han Linshan , Xu Weihao , Wang Yingjia , Zhang Yushuai
Published: September 2023

The mechanical calculation model of rotary-vertical (RV) reducer is established on the basis of considering displacement and stiffness. Without considering the manufacturing error, the parameters of the RV reducer are input into the model and solved by MATLAB calculation software. Comparing the solution results with the analysis results based on Hertz contact theory, the error is within a reasonable range, which verifies the reliability of the mechanical calculation model. The manufacturing errors of the RV reducer based on the high-precision measuring instrument were imported into the mechanical calculation model for solving, the results of the force analysis of the tooth surface of the cycloidal pinwheel considering the manufacturing errors were obtained. The maximum value of the load was 1713N, and the number of meshing teeth was 17 pairs. Compared with the case without manufacturing error, the maximum value of load increased by 89% and the number of meshed teeth decreased by two pairs. Based on the existing experimental data, the force on the tooth surface of the cycloid pinwheel after considering the manufacturing error is closer to the actual situation.
Receipt of BNT162b2 Vaccine and COVID-19 Ambulatory Visits in US Children Younger Than 5 Years
Authors: Tartof Sara Y. , Frankland Timothy B. , Slezak Jeff M. , Puzniak Laura , Ackerson Bradley K. , Jodar Luis , McLaughlin John M.
Published: September 2023

This study examines the association of the receipt of wild-type BNT162b2 vaccine with medically attended COVID-19 outcomes among children younger than 5 years in the US.
Vitamin B2‐Based Ferroptosis Promoter for Sono‐Enhanced Nanocatalytic Therapy of Triple‐Negative Breast Cancer
Authors: Zhou Mengjiao , Yuan Minjian , Jin Yilan , Zhou Qianqian , Yu Yuting , Li Jianan , Dai Xing , Zheng Xiaohua , Yu Haijun , Wang Weiqi
Published: September 2023

Ferroptosis featured by iron‐dependent lipid peroxidation plays a critical role in tumor regression, offering an alternative therapeutic target for the treatment of aggressive triple‐negative breast cancer. However, the traditional delivery strategy to enrich iron deposition is limited in producing a surplus of lipid oxidation because of the aggressive antioxidant response established in solid tumors. Here, vitamin B2‐ferric chloride nanocomplex self‐assembled through the coordination of ferric iron and hydroxy groups to simultaneously promote iron accumulation and oxidative stress is employed. It is observed that the self‐assembly nanostructures with appropriate size enable effective delivery of the therapeutic agents to the tumor site and cancer cells. More importantly, sonosensitizer vitamin B2 and ferric chloride cooperatively facilitate the production of reactive oxygen species and amplify nanocatalytic therapy. To further disrupt the antioxidant system, metformin with solute carrier family 7 member 11 inhibitory activity is used to synergistically boost ferroptosis of tumor cells. The combinational ferroptosis promoter exhibits augmented nanocatalytic antitumor efficacy in 4T1 tumor‐bearing mice with negligible adverse effects. Taken together, this study may provide a novel paradigm of self‐assembled vitamin B2‐ferric nanocomplex for ferroptosis regulation.
Harnessing Metal/Oxide Interlayer to Engineer the Memristive Response and Oscillation Dynamics of Two‐Terminal Memristors
Authors: Nath Shimul Kanti , Sun Xiao , Nandi Sanjoy Kumar , Chen Xi , Wang Zhongrui , Das Sujan Kumar , Lei Wen , Faraone Lorenzo , Rickard William D. A. , Elliman Robert G.
Published: September 2023

Devices with volatile memristive switching and self‐sustained relaxation oscillations have received significant attention for their use in neuromorphic computing and solving optimization problems. However, obtaining devices with stable response and reliable oscillation remains challenging. This work describes the utility of metal/oxide interlayers in achieving reliable device performance with tuneable characteristics using Nb‐Nb2O5‐Pt structures. Detailed physical characterization of the Nb/Nb2O5 interlayer region shows that it consists of a thin, near‐stoichiometric Nb2O5 and an NbOx layer with a graded oxygen content. The impact of these interlayers on device performance is assessed by investigating their switching characteristics and oscillation dynamics. It is shown that the presence of the interlayer has a direct impact on the memristive switching mode and parameters threshold switching characteristics parameters. These dependencies are explained with reference to a lumped‐element circuit model of the device and shown to be dominated by changes in device resistance caused by interlayer formation. Significantly, stable oscillation with tuneable frequency is obtained by increasing the thickness of the reactive Nb electrode. Then, by simulating an array of coupled oscillators, a unique Hamiltonian solver is demonstrated. These results provide pathways for optimizing volatile memristive switching characteristics and guidance on how such devices can be employed to solve combinatorial optimization problems.
A Conjugated Polymer Bearing Perylenediimide (PDI) and Ferrocene (Fc) Exhibiting Stable Data‐Storage Performance
Authors: Han Yue , Shen Junyu , Zhao Qi , Zhou Mingjun , Zhu Dingwei , Hande Chengxun , Zhou Feng , Dong Huilong , Zhang Qijian
Published: September 2023

Polymeric materials have been widely researched and used as active‐layers to fabricate data‐storage resistance random‐access memory (ReRAM) devices. Nevertheless, the problems as drift voltage, weak stability, and low reproducibility largely restrict their practical application in next‐generation memory systems, mainly induced by the molecular stacking defects that limited the efficient charge‐carrier migration throughout the active‐layers. Thus, how to weaken the molecular stacking defects and thus improve the overall ReRAM performance is a scientific issue that needs to be solved urgently. In this work, an organometallic polymer 5,12‐di(thiophen‐2‐l)‐2,9‐di(tridecan‐7‐yl)anthra[2,1,9‐def:6,5,10‐d'e'f']diisoquinoline‐1,3,8,10(2H,9H)‐tetraone P(DTPDI‐Fc) is designed with ferrocene (Fc) and perylenediimide (PDI) building repeats. The X‐ray diffraction (XRD) test confirms the regioregular stacking styles of P(DTPDI‐Fc) in solid states, and atomic force microscope (AFM) measurement verified the continuous and smooth surface morphology of P(DTPDI‐Fc) films. Therefore, the charge carriers can easily inject into P(DTPDI‐Fc) film and can efficiently migrate throughout P(DTPDI‐Fc) films. Thus, P(DTPDI‐Fc) devices show excellent memory behaviors with low high‐conductance state ON‐state current, stable threshold voltage, long‐time stability, and high device reproducibility. This work affords a practical strategy to weaken molecular stacking defects and to improve stacking regioregularity, which will give a guidance for the designing of multilevel data‐storage ReRAM devices in future researches.
Low‐Dose Cu Ions Assisted by Mild Thermal Stimulus Inducing Bacterial Cuproptosis‐Like Death for Antibiosis and Biointegration
Authors: Xue Yang , Zhang Lan , Zhou Jianhong , Chen Jun , Ma Yuwei , Han Yong
Published: September 2023

Methicillin‐resistant Staphylococcus aureus (MRSA) is threatening human health due to its resistance to multiple antibiotics. Excessive copper (Cu) ions target the lipoylated proteins of tricarboxylic acid cycle of cancer cells, inducing proteotoxic stress and their cuproptosis death. Whether cuproptosis plays a part in killing MRSA by low‐dose supplement of Cu ions remains to be explored. Herein, Cu‐doped hydroxyapatite nanorods (PC) are prepared on polyetheretherketone (PEEK) to resist infection and improve PEEK performance in tissue integration with the assistance of near‐infrared (NIR) irradiation, and the mechanism against MRSA is elucidated. Mild photothermal stimulation increases bacterial membrane permeability, accelerating Cu ions’ intake and consequently inducing cuproptosis‐like death of MRSA. It is confirmed by aggregation of dihydrolipoamide S‐acetyltrans‐ferase (DLAT), deactivation of glutathione peroxides 4 (GPX4), and destabilization of Fe─S cluster proteins ferredoxin (FDX1) and lipoyl synthase (LIAS). Fortunately, fibroblast behaviors are upregulated on NIR‐irradiated PC. In vivo, PC with NIR irradiation exhibits outstanding MRSA elimination, reduced inflammation response, and improved biointegration. Overall, it is demonstrated that bacterial cuproptosis‐like death can be induced by Cu ions at a non‐cytotoxic dose when cooperated with mild heat stimulus, and this photothermal strategy of PC has greatly promising application in improving PEEK performance in clinic.
Room‐Temperature Phosphorescent Tough Hydrogels Based on Ionically Crosslinked Nonaromatic Polymers
Authors: Deng Junwen , Liu Haiqi , Liu Deyu , Yu Linxuan , Bai Yunhao , Xie Wendi , Li Tianqi , Wang Cuiping , Lian Yifan , Wang Huiliang
Published: September 2023

Organic photoluminescent materials exhibiting room‐temperature phosphorescence (RTP) have attracted widespread attention. However, most of them can emit phosphorescence only in the solid state, which strongly limits their applications. Herein, a type of phosphorescent hydrogel with excellent mechanical properties is prepared by immersing an as‐prepared poly(vinyl alcohol) (PVA) hydrogel in a poly(sodium maleate) solution and then in a CaCl2 solution, followed by drying under stretching at 90 °C and finally soaking it in deionized water until equilibrium swelling to produce poly(vinyl alcohol)/poly(calcium maleate)‐DS ( PVA/PMACa‐DS) hydrogels. Such hydrogels exhibit excellent mechanical properties, showing tensile strengths up to 15 MPa, due to the presence of strong hydrogen bonding and especially ionic bonding. The PVA/PMACa‐DS hydrogels emit varied phosphorescence emission colors from blue to yellow‐green upon excitation with 312–400 nm light, with a maximum lifetime of 13.4 ms. Experiments and theoretical calculations demonstrate that ionic crosslinking between Ca2+ and nonconventional chromophores prevents the contact of the nonconventional chromophores with water molecules and hence restricts nonradiative decay, leading to RTP emission. This work provides a reliable strategy for designing RTP hydrogels with excellent mechanical properties based on nonaromatic polymers for emerging applications.
One‐Pot Synthesis of Tumor‐Microenvironment Responsive Degradable Nanoflower‐Medicine for Multimodal Cancer Therapy with Reinvigorating Antitumor Immunity
Authors: Sun Jiamin , Jiang Kai , Wang Yifan , Liu Yuqing , Wang Ting , Ding Shiyue , Zhang Xianzhi , Xiong Weiwei , Zheng Fenfen , Yang Haitang , Zhu Jun‐Jie
Published: September 2023

Multimodal cancer therapies show great promise in synergistically enhancing anticancer efficacy through different mechanisms. However, most current multimodal therapies either rely on complex assemblies of multiple functional nanomaterials and drug molecules or involve the use of nanomedicines with poor in vivo degradability/metabolizability, thus restricting their clinical translatability. Herein, a nanoflower‐medicine using iron ions, thioguanine (TG), and tetracarboxylic porphyrin (TCPP) are synthesized as building blocks through a one‐step hydrothermal method for combined chemo/chemodynamic/photodynamic cancer therapy. The resulting nanoflowers, consisting of low‐density Fe2O3 core and iron complex (Fe‐TG and Fe‐TCPP compounds) shell, exhibit high accumulation at the tumor site, desirable degradability in the tumor microenvironment (TME), robust suppression of tumor growth and metastasis, as well as effective reinvigoration of host antitumor immunity. Triggered by the low pH in tumor microenvironment, the nanoflowers gradually degrade after internalization, contributing to the effective drug release and initiation of high‐efficiency catalytic reactions precisely in tumor sites. Moreover, iron ions can be eliminated from the body through renal clearance after fulfilling their mission. Strikingly, it is also found that the multimodal synergistic therapy effectively elicits the host antitumor immunity without inducing additional toxicity. This easy‐manufactured and degradable multimodal therapeutic nanomedicine is promising for clinical precision oncology.
Leveraging 3D Bioprinting and Photon‐Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs
Authors: Gil Carmen J. , Evans Connor J. , Li Lan , Allphin Alex J. , Tomov Martin L. , Jin Linqi , Vargas Merlyn , Hwang Boeun , Wang Jing , Putaturo Victor , Kabboul Gabriella , Alam Anjum S. , Nandwani Roshni K. , Wu Yuxiao , Sushmit Asif , Fulton Travis , Shen Ming , Kaiser Jarred M. , Ning Liqun , Veneziano Remi , Willet Nick , Wang Ge , Drissi Hicham , Weeks Eric R. , Bauser‐Heaton Holly D. , Badea Cristian T. , Roeder Ryan K. , Serpooshan Vahid
Published: September 2023

3D bioprinting is revolutionizing the fields of personalized and precision medicine by enabling the manufacturing of bioartificial implants that recapitulate the structural and functional characteristics of native tissues. However, the lack of quantitative and noninvasive techniques to longitudinally track the function of implants has hampered clinical applications of bioprinted scaffolds. In this study, multimaterial 3D bioprinting, engineered nanoparticles (NPs), and spectral photon‐counting computed tomography (PCCT) technologies are integrated for the aim of developing a new precision medicine approach to custom‐engineer scaffolds with traceability. Multiple CT‐visible hydrogel‐based bioinks, containing distinct molecular (iodine and gadolinium) and NP (iodine‐loaded liposome, gold, methacrylated gold (AuMA), and Gd2O3) contrast agents, are used to bioprint scaffolds with varying geometries at adequate fidelity levels. In vitro release studies, together with printing fidelity, mechanical, and biocompatibility tests identified AuMA and Gd2O3 NPs as optimal reagents to track bioprinted constructs. Spectral PCCT imaging of scaffolds in vitro and subcutaneous implants in mice enabled noninvasive material discrimination and contrast agent quantification. Together, these results establish a novel theranostic platform with high precision, tunability, throughput, and reproducibility and open new prospects for a broad range of applications in the field of precision and personalized regenerative medicine.
A Wearable Touch‐Activated Device Integrated with Hollow Microneedles for Continuous Sampling and Sensing of Dermal Interstitial Fluid
Authors: Abbasiasl Taher , Mirlou Fariborz , Mirzajani Hadi , Bathaei Mohammad Javad , Istif Emin , Shomalizadeh Narges , Cebecioğlu Rümeysa Emine , Özkahraman Ecem Ezgi , Yener Umut Can , Beker Levent
Published: September 2023

Dermal interstitial fluid (ISF) is emerging as a rich source of biomarkers that complements conventional biofluids such as blood and urine. However, the impact of ISF sampling in clinical applications has been limited owing to the challenges associated with extraction. The implementation of microneedle‐based wearable devices that can extract dermal ISF in a pain‐free and easy‐to‐use manner has attracted growing attention in recent years. Here, a fully integrated touch‐activated wearable device based on a laser‐drilled hollow microneedle (HMN) patch for continuous sampling and sensing of dermal ISF is introduced. The developed platform can produce and maintain the required vacuum pressure (as low as ≈ −53 kPa) to collect adequate volumes of ISF (≈2 µL needle−1 h−1) for medical applications. The vacuum system can be activated through a one‐touch finger operation. A parametric study is performed to investigate the effect of microneedle array size, vacuum pressure, and extraction duration on collected ISF. The capability of the proposed platform for continuous health monitoring is further demonstrated by the electrochemical detection of glucose and pH levels of ISF in animal models. This HMN‐based system provides an alternative tool to the existing invasive techniques for ISF collection and sensing for medical diagnosis and treatment.
Fast Gas‐Adsorption Kinetics in Supraparticle‐Based MOF Packings with Hierarchical Porosity
Authors: Fujiwara Atsushi , Wang Junwei , Hiraide Shotaro , Götz Alexander , Miyahara Minoru T. , Hartmann Martin , Apeleo Zubiri Benjamin , Spiecker Erdmann , Vogel Nicolas , Watanabe Satoshi
Published: September 2023

Metal–organic frameworks (MOFs) are microporous adsorbents for high‐throughput gas separation. Such materials exhibit distinct adsorption characteristics owing to the flexibility of the crystal framework in a nanoparticle, which can be different from its bulk crystal. However, for practical applications, such particles need to be compacted into macroscopic pellets, creating mass‐transport limitations. In this work, this problem is addressed by forming materials with structural hierarchy, using a supraparticle‐based approach. Spherical supraparticles composed of nanosized MOF particles are fabricated by emulsion templating and they are used as the structural component forming a macroscopic material. Zeolitic imidazolate framework‐8 (ZIF‐8) particles are used as a model system and the gas‐adsorption kinetics of the hierarchical material are compared with conventional pellets without structural hierarchy. It is demonstrated that a pellet packed with supraparticles exhibits a 30 times faster adsorption rate compared to an unstructured ZIF‐8 powder pellet. These results underline the importance of controlling structural hierarchy to maximize the performance of existing materials. In the hierarchical MOFs, large macropores between the supraparticles, smaller macropores between individual ZIF‐8 primary particles, and micropores inherent to the ZIF‐8 framework collude to combine large surface area, defined adsorption sites, and efficient mass transport to enhance performance.
Spontaneous Vortex‐Antivortex Pairs and Their Topological Transitions in a Chiral‐Lattice Magnet
Authors: Yu Xiuzhen , Kanazawa Naoya , Zhang Xichao , Takahashi Yoshio , Iakoubovskii Konstantin V. , Nakajima Kiyomi , Tanigaki Toshiaki , Mochizuki Masahito , Tokura Yoshinori
Published: September 2023

The spontaneous formation and topological transitions of vortex‐antivortex pairs have implications for a broad range of emergent phenomena, for example, from superconductivity to quantum computing. Unlike magnets exhibiting collinear spin textures, helimagnets with noncollinear spin textures provide unique opportunities to manipulate topological forms such as (anti)merons and (anti)skyrmions. However, it is challenging to achieve multiple topological states and their interconversion in a single helimagnet due to the topological protection for each state. Here, the on‐demand creation of multiple topological states in a helimagnet Fe0.5Co0.5Ge, including a spontaneous vortex pair of meron with topological charge N = −1/2 and antimeron with N = 1/2, and a vortex‐antivortex bundle, that is, a bimeron (meron pair) with N = −1 is reported. The mutual transformation between skyrmions and bimerons with respect to the competitive effects of magnetic field and magnetic shape anisotropy is demonstrated. It is shown that electric currents drive the individual bimerons to form their connecting assembly and then into a skyrmion lattice. These findings signify the feasibility of designing topological states and offer new insights into the manipulation of noncollinear spin textures for potential applications in various fields.
An Enzymatic Electrochemical Biosensing Interface Developed by The Laser‐Induced Graphene Electrode
Authors: Liu Mingyang , Zhao Guangyao , Yang Cheng , Wang Han , Cheng Jing
Published: September 2023

Laser‐inducing provides a cost‐effective, easily‐manufacturable, and environment‐friendly approach to directly transfer carbon‐rich polymers into graphene materials, which attracts attention from various fields, such as sensors, electrocatalysts, micro‐supercapacitors, etc. Laser‐induced graphene (LIG) benefits from the intrinsic properties of graphene, for example, high conductivity, high electroactivity, and high specific area. In this work the potential of laser‐induced graphene in constructing an enzymatic electrochemical biosensing interface is evaluated. Here, a laminar‐structured laser‐induced graphene material is fabricated by laser engraving with polyimide. After deposition of the electron mediator ferrocene, a conjugated enzyme complex of bovine serum albumin‐glucose oxidase (BSA‐GOx) is modified on the laser‐induced graphene by cross‐linking. The fabricated glucose oxidase/ferrocene/LIG (GOx/Fc/LIG) biosensor achieves high sensitivity of 11.3 µA mM−1 cm−2), wide linear range of 0–11 mM, and low detection of limit of 0.04 µM. The LIG electrodes exhibit high flexibility with bending angle as high as 60° without observed conductivity change. The repeatability and robustness of the developed LIG biosensor in detection of real serum samples empower it with great potential in clinical implementation in the future.
Asymmetric [4+2]‐Cycloaddition of Anthracene Derivatives via Hydrazone Activation
Authors: Łukasik Beata , Ossowski Jakub , Frankowski Sebastian , Albrecht Łukasz
Published: September 2023

Enantio‐ and diastereoselective dearomative [4+2]‐cycloaddition reaction between N,N‐dimethylhydrazone derived from 9‐anthracenecarboxaldehyde and α,β‐unsaturated aldehydes is reported. The developed strategy utilizes HOMO‐rising activation of diene (via hydrazone formation) and aminocatalytic LUMO‐lowering activation of dienophile (via iminium ion formation). High chemical and stereochemical efficiency have been obtained owing to the application of Jørgensen catalyst. Target cycloadducts were subjected to selected transformations aiming at unmasking the hydrazone moiety that proceeded with preservation of optical purity introduced in the organocatalytic step.
Tetrabutylammonium Halides as Selectively Bifunctional Catalysts Enabling the Syntheses of Recyclable High Molecular Weight Salicylic Acid‐Based Copolyesters
Authors: Ren Fangping , Xian Ji , Jia Zhaowei , Chen Zhichun , Fu Hongjun , Wang Rui , Chu Wen‐Dao , Pan Xiaobo , Wu Jincai
Published: September 2023

To synthesize high molecular weight poly(phenolic ester) via a living ring‐opening polymerization (ROP) of cyclic phenolic ester monomers remains a critical challenge due to serious transesterification and back‐biting reactions. Both phenolic ester bonds in monomer and polymer chains are highly active, and it is difficult so far to distinguish them. In this work, an unprecedented selectively bifunctional catalytic system of tetra‐n‐butylammonium chloride (TBACl) was discovered to mediate the syntheses of high molecular weight salicylic acid‐based copolyesters via a living ROP of salicylate cyclic esters (for poly(salicylic methyl glycolide) (PSMG), Mn=361.8 kg/mol, Ð<1.30). Compared to previous catalysis systems, the side reactions were suppressed remarkably in this catalysis system because phenolic ester bond in monomer can be selectively cleaved over that in polymer chains during ROP progress. Mechanistic studies reveal that the halide anion and alkyl‐quaternaryammonium cation work synergistically, where the alkyl‐quaternaryammonium cation moiety interacts with the carbonyl group of substrates via non‐classical hydrogen bonding. Moreover, these salicylic acid‐based copolyesters can be recycled to dimeric monomer under solution condition, and can be recycled to original monomeric monomers without catalyst under sublimation condition.
When Is a Bond Broken? The Polarizability Perspective.
Authors: Hait Diptarka , Head‐Gordon Martin
Published: September 2023

The question of when a chemical bond can be said to be broken is of fundamental chemical interest but has not been widely studied. Herein we propose that the maxima of static polarizability along bond dissociation coordinates naturally define cutoff points for bond rupture, as they represent the onset of localization of shared electron density into constituent fragments. Examples of computed polarizability maxima over the course of bond cleavage in main‐group and transition metal compounds are provided, across covalent, dative and charge‐shift bonds. The behavior along reaction paths is also considered. Overall, the static polarizability is found to be a sensitive reporter of electronic structure reorganization associated with bond stretching, and thus can serve as a metric for describing bond cleavage (or diagnose the absence of a chemical bond).
Dynamic Metal‐ligand Coordination for Fluorescence Color Regulation of Hydrazone‐based Bistable Photoswitches
Authors: Zhang Diankun , Zhao Jufu , Shao Aiwen , Li Jiangang , Zhang Ye , Liu Shujuan , Ma Yun , Zhao Qiang
Published: September 2023

Achieving effective manipulation of emission color in photoresponsive materials is crucial for various advanced photonic applications. In this study, we designed and synthesized a hydrazone compound 1, ethyl (Z)‐2‐(2‐([2,2′:6′,2′′‐terpyridin]‐4′‐yl)hydrazineylidene)‐2‐(4‐(diphenylamino)phenyl)acetate, which possesses a push‐pull structure incorporating triphenylamine and terpyridine. The emission intensity of compound 1 can be repeatedly switched “off” and “on” by irradiation with visible light and UV light, which induces the isomerization transition between the Z and E forms. In addition, compound 1 is capable of changing its emission wavelength from 540 nm to 607 nm through coordination with different zinc salts in toluene/CH2Cl2 mixture (v : v=1 : 1). Importantly, we have successfully achieved dynamic manipulation of fluorescence color and intensity by altering the counterions of zinc complexes and switching the isomer from Z to E. Moreover, both compound 1 and its zinc complexes demonstrate remarkable photoswitchable properties with different fluorescence colors in the thin films. Finally, these films with various fluorescence colors were used for the production of luminescent tags.
Cost stickiness behavior and environmental uncertainty in different strategies: Evidence from Southeast Asia
Authors: Restuti Mitha Dwi , Gani Lindawati , Shauki Elvia R. , Leo Lianny
Published: September 2023

Managers consider environmental uncertainty in making decisions. Accordingly, this study aims to test the positive effect of environmental uncertainty on cost stickiness. This study also investigates the effects of environmental uncertainty on cost stickiness under different strategies. Further, firms need more able managers to deal with uncertain environments. This study observes the different effects of environmental uncertainty on cost stickiness when managers have varying levels of managerial ability. We run the panel regression analysis of 23,298 firm‐year observations in Southeast Asian countries in 2013–2019. This study documents that environmental uncertainty increases cost stickiness, and the effects are qualitatively similar for prospector and defender strategies. Further, the effect of environmental uncertainty on cost stickiness is stronger in firms with low managerial ability for both the prospector and defender strategies. Greater environmental uncertainty increases cost stickiness (ratio of SG&A to sales). This increase can be interpreted as a negative signal for future profits and a positive signal that firms retain resources to meet future sales expectations. Managerial ability affects cost stickiness. Hence, less managerial ability strengthens the relationship between environmental uncertainty and cost stickiness. This study operationalizes environmental uncertainty using three dimensions: munificence, dynamism, and complexity, which are arguably more comprehensive than prior studies that only use a single uncertainty dimension. This study also adds strategy and managerial ability to the relationship between environmental uncertainty and cost behavior. It demonstrates that firms deal with uncertainty based on their competitive advantage and managerial capabilities. This study documents the cost behavior of Southeast Asian.
Bubble Interfacial Area in a Swirling Contactor: Experiments and Computational Fluid Dynamics Simulations
Authors: Xu Xiao , Gong Chunkai , Wang Shuo , Yang Qiang , Xi Zhenhao
Published: September 2023

The bubble size, gas holdup, and interfacial area in a swirling contactor were investigated through experiments and simulations. The interfacial area was obtained for liquids and gases with Reynolds numbers Rel and Reg, respectively. The contactor was divided into twelve subregions. Rel was negatively related to bubble size, gas holdup, and interfacial area, whereas Reg was positively associated. The maximum bubble interfacial area for the entire swirling contactor was 196.3 m−1 with a gas‐liquid ratio of 0.022. There is a trade‐off between centrifugal acceleration and bubble size for interfacial area.
Dual‐single‐atoms of Pt–Co boost sulfur redox kinetics for ultrafast Li–S batteries
Authors: Wu Hanyan , Gao Xuejie , Chen Xinyang , Li Weihan , Li Junjie , Zhang Lei , Zhao Yang , Jiang Ming , Sun Runcang , Sun Xueliang
Published: September 2023

Applications of lithium–sulfur (Li–S) batteries are still limited by the sluggish conversion kinetics from polysulfide to Li2S. Although various single‐atom catalysts are available for improving the conversion kinetics, the sulfur redox kinetics for Li–S batteries is still not ultrafast. Herein, in this work, a catalyst with dual‐single‐atom Pt‐Co embedded in N‐doped carbon nanotubes (Pt&Co@NCNT) was proposed by the atomic layer deposition method to suppress the shuttle effect and synergistically improve the interconversion kinetics from polysulfides to Li2S. The X‐ray absorption near edge curves indicated the reversible conversion of Li2Sx on the S/Pt&Co@NCNT electrode. Meanwhile, density functional theory demonstrated that the Pt&Co@NCNT promoted the free energy of the phase transition of sulfur species and reduced the oxidative decomposition energy of Li2S. As a result, the batteries assembled with S/Pt&Co@NCNT electrodes exhibited a high capacity retention of 80% at 100 cycles at a current density of 1.3 mA cm−2 (S loading: 2.5 mg cm−2). More importantly, an excellent rate performance was achieved with a high capacity of 822.1 mAh g−1 at a high current density of 12.7 mA cm−2. This work opens a new direction to boost the sulfur redox kinetics for ultrafast Li–S batteries.
Polymorphism and Light‐Driven Forward Movement of TPE Derivative Micro‐Crystal due to ArH‐pi Interactions Difference
Authors: Hu Ming , Ye Feng‐Ying , Yu Wei , Sheng Kang , Wang Weizhou , Zheng Yan‐Song
Published: September 2023

Aggregation‐induced emission (AIE) and aggregation‐caused quenching (ACQ) are two classes of opposite luminescence phenomena. It is almost impossible to show both AIE and ACQ effect simultaneously by the same molecule. However, here we report that a simple TPE derivative TAP‐TPE grows into both AIE crystals and ACQ ones. It is found that equatorial, contact distance‐longer and weak ArH‐π interactions exist in AIE crystals while vertical, contact distance‐shorter and strong ArH‐π interactions appear in ACQ crystals. Theoretical calculation of electron density on the interaction atoms unveils that ACQ crystals have much larger change in electron density than AIE ones, suggesting that the intermolecular electron transfer aroused by the strong ArH‐π hydrogen bonds leads to ACQ phenomenon. This result provides a new insight into the emission mechanism in aggregation state. Interestingly, due to the ArH‐pi interactions difference, only one of five kinds of crystals shows rapid photochromism, and can act as multimode anti‐counterfeiting materials. Very exceptionally, for the first time we find that the photochromic micrometric rod‐like crystal even makes forward rolling movement as it repeatedly bends and straightens by responding to on and off of the ultraviolet light irradiation, displaying potential for photo‐actuator and light‐driven micro‐vehicle.
Deinterpenetration of IRMOF‐9.
Authors: Crom Audrey B. , Strozier Joseph L. , Tatebe Caleb J. , Carey Cassidy A. , Feldblyum Jeremy I. , Genna Douglas T.
Published: September 2023

One of the iconic characteristics of metal‐organic frameworks (MOFs) is the possesssion of guest‐accessible pores. Increasing pore size has a direct and often beneficial impact on a MOF's adsorption and separation properties. However, as pore size increases, the resulting void spaces are often filled by interpenetrated frameworks, where one or more networks crystallize within the pore system of another identical network, reducing the MOF's free volume and pore size. Furthermore, due to the thermodynamic favorability of interpenetration during solvothermal synthesis, techniques to synthetically differentiate interpenetrated from non‐interpenetrated MOFs are paramount. This study reports the synthesis of deinterpenetrated IRMOF‐9 via halide mediated deinterpenetrative conversion of Zn4O‐derived IRMOF‐9. IRMOF‐9, when treated with ethylammonium bromide, is quasi‐selectively etched, revealing the non‐interpenetrated analogue, IRMOF‐10 (deinterpenetrated IRMOF‐9), which can be isolated prior to complete dissolution by the bromide solution. Dye adsorption, surface area and pore size distribution analysis, and powder X‐ray diffraction are consistent with successful deinterpenetration.
One‐Pot Stereoselective Synthesis of Different Fused Multicyclic Iminosugars Based on the Iminium‐Ion Intermediate
Authors: Xie Song , Wu Jilai , Zhou Likai , Wei Chao , Li Xiaoliu , Chen Hua
Published: September 2023

Comprehensive Summary

Different novel fused multicyclic iminosugars were synthesized from D‐ribose tosylate, aniline and vinyl ethyl ether by one‐pot three‐component stereoselective [4+2] reaction at different temperatures. The iminium‐ion is the key intermediate for the reaction. As a result, several complex fused iminosugars 3a were obtained by aza‐Diels‐Alder mechanism at 60 °C, while a series of aza‐C‐glycosides 5a were prepared by Mannich reaction at room temperature accompanied by another tetrahydroquinoline‐fused iminosugars 4a (tricyclic derivatives) through aza‐Diels‐Alder cycloaddition. This strategy will help to construct structurally diverse and bioactive iminosugar analogues.
Quantitative analysis of color characteristics for Yangjiabu New Year woodblock paintings based on color science and spectral imaging
Authors: Zhang Fuzheng
Published: September 2023

The intangible cultural heritage of Yangjiabu New Year woodblock paintings (YNYWPs) has numerous potential cultural, artistic, and economic values. The quantitative color characteristics of YNYWPs, which have always been disregarded, can offer evidence in support of their inheritance and conservation. Utilizing the principles and methods of color science and spectral imaging technology, the color characteristics, including spectral characteristics, colorimetric characteristics, and color combination regularity, were quantitatively investigated by measuring and capturing the representative works. The results show that the spectral reflectances of the seven colors (i.e., red, yellow, green, cyan, violet, black, and paper color) adopted in the selected paintings have no significant structured features and can be accurately described using the first six derived eigenvectors by principal component analysis. The Xuan paper and the yellow color have higher reflectance than the other five colors. Correspondingly, their Commission Internationale de l'Eclairage (CIE) 1964 XYZ stimulus values are also relatively high. The others cover a narrow range in the CIE XYZ system. When transformed into the CIELAB color space, the seven colors can be relatively uniformly distributed in the color space. With regards to the color combination regularity, red, yellow, and cyan tend to occupy a large area in the selected paintings. In contrast, the other colors, especially green, are not frequently used. The resulting data of the color combination regularity quantitatively verify the color combination knack that is transmitted by word of mouth from generation to generation.