bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence and risk factors of deep venous thrombosis of hospitalizations in plateau: A cross-section analysis
Authors: Sun Lijuan , Pan Shiqin , Li Yuemei , Luo Mingqin , Li Xiaofang , Ma Hongmei , Zhang Jingni , Wang Limei , Yong Cuo
Published: July 2023

Background: To elucidate the prevalence of and associated risk factors for deep venous thrombosis (DVT) in hospitalized patients in plateau areas.
Methods: We enrolled patients who were hospitalized in three grade III-a hospitals in Qinghai Province, China, between January 2020 and October 2020. The demographic and clinical data and laboratory results were collected at admission. Simultaneously, we performed ultrasonography of the bilateral lower extremities, and the length of hospital stay was collected before discharge.
Results: In total, 3432 patients were enrolled; of them, 159 were diagnosed with DVT (4.60%). The total length of hospital stay of patients with DVT was longer than that of those without DVT (16.40 ± 7.66 vs. 14.77 ± 8.55 days). Age of >50 years (OR = 1.969, 95% CI: 1.192–3.252, P = 0.008), residence altitude of ≥3000 m (OR = 2.344, 95% CI: 1.238–4.438, P = 0.009), D-dimer level of ≥0.5 mg/L (OR = 2.53, 95% CI: 1.813–3.529, P < 0.001), comorbidities (OR = 1.906, 95% CI: 1.365–2.662, P < 0.001),history of varicose veins (OR = 2.202, 95% CI: 1.096–4.425, P = 0.027), and current medications (OR = 2.591, 95% CI: 1.857–3.616, P < 0.001) were identified as risk factors for DVT in plateau areas.
Conclusion: The prevalence of DVT in hospitalized patients in plateau areas was 4.60%. We recommend considering individualized risk stratification (age > 50 years, residence altitude ≥ 3000 m, history of varicose veins, D-dimer level ≥ 0.5 mg/L, current medications, and comorbidities) for patients at admission.
Cervical amniotic fluid bacterial colonization, antibiotic susceptibility and associated factors among women with premature rupture of membranes at Mbarara Regional Referral Hospital, Southwestern Uganda
Authors: Ainomugisha Brenda , Bazira Joel , Agaba David Collins , Owaraganise Asiphas , Tibaijuka Leevan , Mugyenyi Godfrey R , Kayondo Musa , Muhumuza Joy , Migisha Richard , Ngonzi Joseph
Published: July 2023

Background Bacterial colonization is a recognized cause of premature rupture of membranes (PROM), a predictor of poor maternal and fetal outcomes. Despite routine use of antibiotics in women with PROM, data on antibiotic susceptibility patterns in Uganda are limited. We determined the prevalence and associated factors of cervical amniotic fluid bacterial colonization, and described the bacterial isolates and antibiotic susceptibility patterns among women seeking care at Mbarara Regional Referral Hospital (MRRH) in Southwestern Uganda. Methods We conducted a cross-sectional study at MRRH from December 21, 2020 to June 12, 2021. We consecutively enrolled women with PROM at ≥ 24 weeks of gestation, and aseptically picked two endo-cervical swabs irrespective of prior antibiotic use. Aerobic cultures were performed on blood, chocolate, MacConkey agars and incubated at 35–37◦C for 24–72 hours. Polymerase chain reaction (PCR) was performed on culture-negative samples. Antibiotic susceptibility was performed via Kirby-Bauer disk diffusion and dilution method. Interviewer-administered questionnaires were used to obtain participants’ characteristics. We performed multivariable logistic regression to determine factors associated with bacterial colonization. Results We enrolled 144 participants with mean age of 26.5 ± 6.2 years. Prevalence of cervical amniotic bacterial colonisation was 35.4% (n = 51; 95%CI: 28.0–43.7). Six bacteria were isolated:Klebsiella pneumoniae(n = 15; 34.1%),Staphylococcus aureus(n = 11; 25.0%),Enterobacter agglomerans(n = 10; 22.7%),Escherichia coli(n = 3; 6.8%),Streptococcus spp(n = 3; 6.8%), andEnterococcus faecalis(n = 2; 4.6%). Ciprofloxacin exhibited the highest sensitivity (88.6%), followed by cefuroxime (75%), while all isolated bacteria demonstrated resistance to ampicillin. Factors independently associated with cervical amniotic fluid bacterial colonisation were prime gravidity (aOR = 2.69; 95%CI: 1.07–6.71,p = 0.035), obesity (aOR = 3.15; 95%CI: 1.10–9.11,p = 0.024) and being referred-in (aOR = 2.37; 95% CI: 1.04–5.3,p = 0.038). Conclusion Approximately one-third of the women had cervical amniotic fluid bacterial colonization, with all the bacterial isolates being resistant to ampicillin —the recommended first line of treatment for PROM by the Ministry of Health. There is a need to review the guidelines for the prophylactic use of ampicillin in PROM in our setting. Revising treatment protocols and considering alternative antibiotics based on local resistance patterns could improve patient outcomes and prevent complications associated with ineffective antibiotic therapy in the context of PROM.
Removal of antimony and aniline from wastewater by PMS combined with electrocoagulation
Authors: Dong Wenjie , Shu Yu , Cai Ao , Huang Yuehong , Qi Beimeng , Zhao Jingrao , Fu Hailu
Published: July 2023

Antimony (Sb) and aniline are typical pollutants in printing and dyeing wastewater. This study explored the simultaneous removal of Sb and aniline by peroxymonosulfate (PMS) combined with electroflocculation (EC) and the removal mechanisms were systematically studied. The effects of PMS concentration, NaCl concentration, and initial pH on the removal efficiency were investigated. Under the optimal condition (anode: iron plate, cathode: aluminum plate, current density: 20 A/m2, PMS concentration: 2.5 mM, NaCl concentration: 0.1 mol/L, and initial pH: 8), Sb and aniline could be removed entirely after 20 min of reaction. The results showed that PMS facilitated the formation of iron flocs, improving the Sb removal efficiency, and electrical activation of PMS was conducive to the removal of aniline. In addition, electron paramagnetic resonance (EPR) analysis and quenching experiments confirmed that 1O2 contributed most to the degradation of aniline, followed by •OH and SO4•−. This study demonstrated that the EC/PMS system could remove heavy metals and organic matter simultaneously, and the system can be extended to treating similar printing and dyeing wastewater.
Planning and Designing The Development of Software Library for Deep Learning
Authors: Rachmawati Oktavia Citra Resmi , Barakbah Ali Ridho , Karlita Tita
Published: July 2023

In recent years, deep learning has achieved noteworthy success in various applications. The existing DL libraries widely used by researchers are too complex and challenging to modify the code functions with the custom mathematical formula for research purposes. Thus, we propose a software library related to deep learning that facilitates researchers and practitioners in academia and industry to mutate the training model function with the specific equation. In this paper, we address preparation before developing a software library for deep learning to inspire the researcher who wants to develop a software library. They can utilize our research methodology step by step to conduct the software library architecture design process. We perform four main phases with different activities that execute sequentially to construct a software library intended for deep learning implementation into code practically, and we produce 11 documents to facilitate the transfer of detailed knowledge from us as the pioneer developer of a software library for deep learning that will be part of Analytical Library Intelligent-computing (ALI) to the following developers.
Gut microbiota characteristics and its immunoregulatory role in inflammatory depression: joint clinical and animal data
Authors: Zhang Kerang , Liu Penghong , Liu Zhifen , Wang Jizhi , Wang Junyan , Gao Mingxue , Zhang Yanyan , Yang Chunxia , Zhang Ai-Xia , Li Gaizhi , Li Xinrong , Liu Sha , Liu Lixin , Sun Ning
Published: July 2023

Previous studies have reported that inflammatory depression is a treatment-resistant depression subtype and that disturbed gut microbiota may be the source of low-grade inflammation. But the gut microbiota’s features and its role of immunoregulation in this subtype of depression remains uncertain. We propose that Toll-like receptor 4 (TLR-4)/nuclear factor kappa-B (NF-κB) and the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome signaling pathway activated by disordered gut microbiota could contribute to intestinal and central inflammation in inflammatory depression. To test this hypothesis, we performed studies in both humans and mice. Gut microbiota composition in stool, inflammation factor and short chain fatty acid (SCFAs) in plasma, inflammatory and permeability marker in intestinal mucosa were analyzed in inflammatory depression patients. Then we performed fecal microbiota transplantation (FMT) and probiotic supplement to determine whether the behavioral phenotypes were linked with disturbed gut microbiota in inflammatory depression. Compared with non-inflammatory depression and HCs, the relative abundance of Bacteroides was significantly higher, and Clostridium was lower in inflammatory depression patients. Further, we found that SCFA-producing species increased with abnormal butanoate metabolism in the inflammatory depression patients following shotgun metagenomic sequencing. After FMT, gut microbiota in inflammatory depression increased inflammatory factors, those including as hs-CRP, TLR-4, NF-κB, NLRP3, Caspase-1, Interleukin-1β (IL-1β), and iba-1. We also found that intestinal mucosal permeability increased in recipient mice with depressive and anxiety-like behaviors. Clostridium butyricum treatment can normalize the gut microbiota, repair “gut leak,” decrease peripheral and central inflammatory factors, and have an antidepressant-like effect in the mouse model inflammatory depression. Together, our study findings indicate that inflammatory depression patients have increased pro-inflammatory genera and decreased SCFA-producing genera. Gut microbiota-derived inflammatory processes mediated by TLR-4/NF-κB–NLRP3 inflammasome signaling pathway are involved in neuroinflammation in inflammatory depression.
Effect of a fermented dairy beverage on treatment-related toxicity and inflammation in locally advanced cervical cancer patients, a randomized placebo-controlled pilot study.
Authors: Castro-Eguiluz Denisse , Morales Julissa Luvián , González Merari Delgadillo , Hernández Clementina Castro , Núñez Aurora Espejel , Rubí Lesbia María Rivera , Escalona Alejandra Rueda , Mancera Christian Aguila , Thomé María Guadalupe Serna , Cetina-Pérez Lucely
Published: July 2023

Purpose. This study aimed to analyze the effect of a probiotic-rich fermented dairy beverage, compared to a placebo, on gastrointestinal toxicity, inflammatory response, chronic toxicity, and quality of life, in locally advanced cervical cancer (LACC) patients.
Methods. A randomized, double blind, placebo-controlled pilot study assigned LACC patients to the probiotic group (n=21) or the placebo group (n=21). Intervention with probiotic or placebo beverage began 2 weeks before treatment through 90 days after treatment. The frequency and severity of toxicity symptoms, nutritional parameters, serum cytokines, fecal calprotectin, proctopathy, and quality of life were evaluated throughout treatment.
Results.Lower frequency and severity of vomit were observed in the probiotic group compared to placebo (15% vs 40%, p=0.03). No differences were observed in the frequency of symptoms among groups, including diarrhea. A trend was observed toward lower levels of inflammatory cytokines in the probiotic group. No significant differences were observed in the development of proctopathy.
Conclusion.This study demonstrated the fermented dairy beverage’s beneficial effect on reducing the frequency and severity of vomit and a tendency to lower inflammation. Still, it did not provide benefits regarding other treatment-related toxicities, probably due to the small sample size. Trial Registration Number NCT05736315, retrospectively registered on February 16, 2023.
Big Data Intelligent Analysis Technology for the Study of Spatial and Time Trends in the Development of Large Cities
Authors: Mulyukova K. V. , Mulyukov I. V. , Kureichik V. M.
Published: July 2023

The purpose of this research is to study modern problems and prospects for solving the processing of big data containing information about real estate, as well as the possibility of practical implementation of the methodology for processing such data arrays by designing and filling a special graphic abstraction «metahouse» on a practical example.

Materials and methods. The study includes a review of bibliographic sources on the problems of big data analysis and their application in the modern field of construction of large cities. During the study, a technique for presenting data in a graphical form – abstraction was used. The mathematical basis of the technique is the use of multidimensional spaces, where measurements are the characteristics of individual objects. Computer simulation of a practical problem was applied using the C# programming language. Big data storage is based on the MongoDB server. To visualize data, a Web interface based on HTML and CSS is used.

Results. In the course of the work, the main characteristics of big data were identified, and the specifics of data arrays consisting of information about real estate objects in a large city were described. When processing data consisting of information about real estate objects of a large city, certain difficulties arise. Thereby, methods for effectively solving the set practical task of processing and searching for patterns in a large data array were proposed: «metahouse» abstraction, data aggregator.

Tabular data were obtained for a large city by analyzing three million records containing more than 10 data groups, with a basic set of parameters: floor, number of floors, price, area, living area, kitchen area, type, operation. A MongoDB cluster was created on several computers, each of which was working with its own data set without intermediate results.

The results of the computational experiment showed that when using the graphical form (vector) of big data representation, the costs and time for interpreting mining data were reduced.

Combining big data processing methods and their presentation through graphical abstraction allows getting new results from existing data sets.

Conclusion. During the study, it was found that the presentation of groups of the received data in a graphic image has a number of advantages over a tabular presentation of data (a vector image is easy to scale, the ability to compare without plotting).

The proposed way for visualizing big data by constructing abstract vector images is an alternative to traditional tables, allowing you to take a different look at data arrays and the results of their processing. The results obtained can be used both for the primary study of big data processing technologies and as a basis for the development of real applications in the following areas: analysis of changes in the area of houses over time, analysis of changes in the number of floors of urban development, dynamics and distribution of supply and demand, etc.
Customer Churn Prevention For E-commerce Platforms using Machine
Learning-based Business Intelligence
Authors: Shaker Reddy Pundru Chandra , Sucharitha Yadala , Vivekanand Aelgani
Published: July 2023

Aims & Background:

Businesses in the E-commerce sector, especially those in the business-
to-consumer segment, are engaged in fierce competition for survival, trying to gain access to
their rivals' client bases while keeping current customers from defecting. The cost of acquiring new
customers is rising as more competitors join the market with significant upfront expenditures and
cutting-edge penetration strategies, making client retention essential for these organizations.

Objective:

The main objective of this research is to detect probable churning customers and prevent
churn with temporary retention measures. It's also essential to understand why the customer decided
to go away to apply customized win-back strategies.

Methodology:

Predictive analysis uses the hybrid classification approach to address the regression
and classification issues. The process for forecasting E-commerce customer attrition based on support
vector machines is presented in this paper, along with a hybrid recommendation strategy for
targeted retention initiatives. You may prevent future customer churn by suggesting reasonable offers
or services.

Results:

The empirical findings demonstrate a considerable increase in the coverage ratio, hit ratio, lift degree, precision rate, and other metrics using the integrated forecasting model.

Conclusion:

To effectively identify separate groups of lost customers and create a customer churn retention strategy, categorize the various lost customer types using the RFM principle.
Cultural Values of Life in Charles Dickens’s and Lu Xun’s Works: A Comparative Study
Authors: Lu Hanhao
Published: July 2023

Dickens wrote during the Victorian era in England, a time of industrialization and social changes, while Lu Xun wrote during China’s early 20th century, marked by political turmoil and the transition to modernity. The essay explores the socioeconomic backgrounds of the authors, the portrayal of characters and their struggles, the impact of industrialization and modernization, and the reflection of cultural values and morality. Despite the differences in time and place, both authors address social injustices, advocate for compassion, and challenge prevailing norms. Through their works, readers gain insights into the complexities of their respective eras, the universal human experiences, and the enduring relevance of their literary legacies. The comparative analysis sheds light on the cultural values that shaped their times and invites readers to reflect on the past in shaping a better future.
Consulting support for small and medium business in the Khabarovsk territory
Authors:   The ANO Regional agency for promotion of entrepreneurship, Litvinenko V. A. , Mazankova T. V. ,   The Russian Presidential Academy of National Economy and Public Administration, the  Far-Eastern  institute of management – branch of RANEPA
Published: July 2023

n this article market valuation of consulting services to small and medium business in the Khabarovsk territory is presented. Types of consulting services and corresponding tariffs are analyzed. As a discussion the approach to justifying the cost of consultations by comparing the cost of consultation with the average salary in the Khabarovsk territory of employees of the activity type «professional, scientific and technical activities (in accordance with the All-Russian classifier of types of economic activities, RC 029-2014). Structural analysis of the provided consulting services in the Khabarovsk territory made it possible to identify the most demanded services, as well as increasing interest in business consulting services. Benefits and risks of consulting services are shown.
Living standards in some regions of the Far East
Authors:   The Pokrovsk branch of the Moscow pedagogical state university, Mitroshin I. V.
Published: July 2023

Human life standards are the main questions for many studies, as they reflect socio-economic situation in the region or in the country as a whole. Indicators of the standard of living of the population themselves also have an impact on the economic environment to the same extent as the economy affects them. Analysis of main indicators of the standard of living helps to identify existing problems in the existing economic system. The study analyzes indicators of the gross regional product per capita, the average monthly wage and the ratio of the average monthly wage to the subsistence minimum for 2000–2021in four regions of the Far East – in the Republic of Sakha (Yakutia), in the Khabarovsk and Primorsk territories and in the Amur region. Influence of the standard of living of the population on the demographic situation in these regions is also considered. Based on the results of the study, a certain relationship between the living standards of citizens and the demographic situation in the regions under consideration was determined. A noticeable impact of financial crises and the crisis associated with the covid-19 pandemic on the indicators of living standards in the regions has been revealed. It is determined that these crises have a greater impact on the indicators of the average monthly wage than on the indicator of the gross regional product per capita.
Problems of Consideration of Individual Labor Disputes of Athletes and Coaches in the Jurisdictional Bodies of Sports Federations and Professional Sports Leagues
Authors:   National Research University Higher School of Economics, Rzhepik Yaroslav N.
Published: July 2023

The article is devoted to the problems of consideration of individual labor disputes of athletes and coaches in the jurisdictional bodies of sports federations and professional sports leagues. The current legislation provides for the possibility of creating bodies of pre-trial settlement of disputes in the ﬁeld of physical culture and sports within the structure of all-Russian sports federations and professional leagues, which can consider individual labor disputes of athletes and coaches. At the same time, certain problems arise already at the stage of determining the jurisdiction of these bodies in terms of the possibility of considering individual labor disputes by them. Within the framework of this study, the problems related to the issues of the correlation of labor legislation and legislation on physical culture and sports, related to the procedure and conditions for the formation of jurisdictional bodies, the peculiarities of submitting a dispute for their consideration, and the observance of the principle of equality of the parties are identiﬁed. Proposals have been developed to improve the current legislation.
The jus commune Doctrine and the Formation of Public Law Institutions
Authors:   Immanuel Kant Baltic Federal University, Lonskaya Svetlana V. , Novikov Petr D. ,   Immanuel Kant Baltic Federal University
Published: July 2023

This article considers the role of the jus commune doctrine in the process of formation of institutions of public law in the period 11th-17th century as a functionally organised construction of legal reality. The research is based on the communicative methodology of law and, on the grounds of the historical and legal facts, shows how the functions of the doctrine were manifested when jus commune inﬂuenced the medieval legal reality. It concludes that the jus commune doctrine, based on the axiomatic method, by interpreting the texts of Roman and canon law, ﬁlling legal gaps and eliminating contradictions in customary, canonical and positive law, made a signiﬁcant contribution to the construction of the public law segment of legal reality — the institutions of public law.
PENGARUH FEE AUDIT DAN AUDIT TENURE TERHADAP KUALITAS AUDIT (STUDI EMPIRIS PADA PERUSAHAAN PERTAMBANGAN YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2015 – 2018)
Authors: Kurniati Lia , Yuliusman Yuliusman , Yustien Reni
Published: July 2023

Penelitian ini bertujuan untuk menguji pengaruh variabel fee audit dan audit tenure terhadap kualitas audit pada Perusahaan Pertambangan yang terdapat di Bursa Efek. Penelitian ini menggunakan teknik purpossive sampling. Sampel penelitian ini sebanyak 43 perusahaan di Bursa Efek, namun data yang diperoleh hanya 25 perusahaan dengan periode pengamatan selama tahun 2014 sampai tahun 2018. Sumber data sekunder dalam penelitian ini berasal dari www.idx.co.id. Pengolahan data menggunakan software SPSS 22.0. Alat analisis yang digunakan dalam penelitian ini adalah analisis regresi linear berganda. Berdasarkan hasil analisis dapat disimpulkan bahwa fee audit berpengaruh positif signifikan terhadap kualitas audit, sedangkan audit tenure tidak berpengaruh signifikan terhadap kualitas audit.
Effect of Combined Problem Based Learning and Scaffolding Models on Students’ Critical Thinking Ability
Authors: Widyawati Dyah , Jamhari Mohammad , Binti Non Shamdas Gamar
Published: July 2023

This study aims to determine the effect of Combined problem-based learning and scaffolding models on students’ critical thinking ability at SMP Negeri 21 Palu. This type of research is a quasi experiment. The research was conducted in two class groups: class VII and class VIII B as the experimental class. The data collection technique uses purposive sampling. The main instrument used was the 7th-grade of critical thinking essay test which consisted of 8 questions. Data were analyzed by a non-parametric test. It is the Wilcoxon test signed ranks test. Obtained the results that Asymp.Sig (2-tailed) is 0,000 on the critical thinking ability test, H1 is accepted, this means that there is a significant effect of the combined problem-based learning and scaffolding models on the critical thinking ability of students at SMP Negeri 21 Palu in the 2019 / 2020 school year.
THE INFLUENCE OF PEER TO PEER LENDING (P2P) AND ELECTRONIC MONEY ON INCREASING PROFITS OF MICRO SMALL AND MEDIUM ENTERPRISES (MSME) IN KUDUS REGENCY
Authors: Rhealin Hening Karatri  , Keke Tamara Fahira  , Rozaq Muhammad Yasin
Published: July 2023

Currently, MSMEs must begin to realize the importance of various digital platform services such as peer to peer lending (P2P) and electronic money. The low number of MSME business actors in Kudus Regency compared to MSME business actors in other regencies is one of the reasons for conducting this research. In addition, there is still a lack of research on Peer to peer lending (P2P) and electronic money with the use of connecting/intervening variables. The sampling technique used purposive sampling. The data was obtained using a questionnaire distributed to 91 MSME business actors in Kudus Regency.  Consumer data were analyzed using multiple regression models and path analysis with SPSS.  The results show that there is a direct influence of P2P and electronic money on the increase in MSME profits, the indirect influence of P2P and electronic money on the increase in MSME profits with MSME income as intervening, as well as the direct influence of P2P and electronic money on MSME income.
FOCUS RESEARCH ON HALAL FOOD MARKETING
Authors: Triansyah Fadli Agus
Published: July 2023

Halal food is a category of food or beverage that Muslims may consume according to Islamic law. Halal cuisine must also adhere to strict standards of sanitation and hygiene, which makes it noted for its cleanliness and higher quality. This study utilised a systematic review on halal food marketing scopus database from 2021-2023. In this research, the keyword used is "Halal Food Marketing" in the Scopus database. After conducting the screening, the researchers found 11 articles that met the predetermined criteria. Several research focuses on halal food marketing, namely intention to purchase, halal cosmetics, millennials, religiosity, halal food consumption, Halal brand image, Halal brand satisfaction, Halal brand trust, Halal brand equity, Customer attitude, Product attributes, Marketing stimuli, Halal food , Halal Tourism, halal, marketing, perceived risk, value, trust, purchase intention, product, Halal market, Islamic hospitality, Muslim traveler, Muslim-minority country, Halal hotel, Halal-friendly hotel, Islamic hotel branding, Relational value, utility value, Halal brand resonance, Halal brand relationship quality, supply chain integration, demand for halal products, halal marketing, process quality improvement, food safety concerns, health consciousness on sustainable product performance, Halal foods, Performance, Drivers, and Key success factors. Through proper marketing, halal food producers can increase consumer awareness about their products and expand their market.
The redundant role of plasmacytoid dendritic cells in Primary Sjögren’s syndrome
Authors: Li Rongli , Wang Mu , Deng Chuiwen , Peng Yu , Zhao Lidan , Zhang Wen , Zhou Jiaxin , Chen Yingying , Wang Anqi , Jia Yimeng , Li Mengtao , Zhao Yan , Zeng Xiaofeng , Wu Xunyao , Fei Yunyun
Published: July 2023

Objective: The aim of our present study is to investigate the
role of plasmacytoid dendritic cells (pDCs) in the pathogenesis and type
I interferon (IFN) signatures in Primary Sjögren’s Syndrome (pSS)
patients. Methods: In the present study, we compared the
percentage, activation markers, and representative cytokines secretion
of pDCs derived from treatment-naive pSS and matched healthy controls
(HCs) by flow cytometry. We performed pDC/B co-culture system to explore
the contribution of pDC to B cell functions in pSS. Results:
The percentage of pDC was significantly reduced in the peripheral blood
of pSS. The activation markers (CD80, CD83, and CD86) expressions,
chemokine receptors, and representative cytokines production (IFN-α,
IL-6, and TNF-α) of pDC were similar between pSS and HCs. Only a few
pDCs infiltration were detected in the labial gland. The percentage of
pDCs was negatively correlated with serum IgG, IgA, and anti-SSA
autoantibody levels and resting pDCs were able to efficiently promote B
cells proliferation, activation, differentiation, and antibody
production in vitro. However, there was no difference between HC
and pSS-derived pDCs. Finally, we found that incubation of plasma from
pSS patients could significantly induce pDCs apoptosis than that from
HCs and both IgG and IgA dramatically increased the apoptotic rates of
pDCs. Conclusion: Our data have deciphered the redundant role
of pDC in the type I signature and disease development in pSS. Also, we
demonstrated the decreased percentage of pDC in pSS patients might
result from apoptosis induced by the excess of immunoglobulin (IgG and
IgA).
Recurrent cardiotoxicity in a fluoropyrimidine treated cancer patient – case report and practical recommendations
Authors:   Department of Medical Oncology, Cluj County Emergency Clinic Hospital, Cluj-Napoca, Romania, Deac Andrada Larisa , Pop Raluca Maria ,   "Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania", Crisan Cristina Florina ,   "Cardiomed Medical Center, Cluj- Napoca, Romania"
Published: July 2023

Fluoropyrimidines remain some of the most used chemotherapeutics, despite the appearance in the therapeutic arsenal of targeted therapy and immunotherapy. Fluropyrimidines related cardiotoxicity is an undesirable adverse event and affects almost 20% of patients. The mechanisms of fluoropyrimidine toxicity are closely related to deficient allelic variants of DPYD, but considering the low penetrance and interindividual variability, not all adverse reactions are explained by their presence. In this case, we report a patient with recurrent fluoropyrimidine toxicity without a deficient allelic variant and how this case was managed by the oncologist and cardiologist, considering the need to use fluoropyrimidine in the treatment.
Synchronous anal mucinous adenocarcinoma and anal tuberculosis presenting as chronic anal fistula: Challenging management
Authors:   Department of General Surgery C, Mohammed V University in Rabat, Morocco, Benammi Sarah , Bakali Youness ,   Department of General Surgery C, Mohammed V University in Rabat, Morocco, Alaoui Mouna ,   Department of General Surgery C, Mohammed V University in Rabat, Morocco
Published: July 2023

Metachronous anal tuberculosis to an anal adenocarcinoma is an exceptional condition. The aim of our study was to report management of the first case of synchronized anal canal adenocarcinoma and anal canal tuberculosis and report our multidisciplinary approach. A 71-year-old man was admitted for non-healing anal fistula. Rectal examination at supine position showed an ulcerative growth at the medio-superior quadrant on a radius of 2cm from the anal verge. Digital rectal examination assessed no tumor in the anorectum. Biopsy of fistulae confirmed diagnosis of anal mucinous adenocarcinoma with coexisting anal tuberculosis. Further exploration confirmed diagnosis with no distal metastasis, no active pulmonary tuberculosis and no immunodepression. Adjuvant anti-bacillary chemotherapy was initiated 1 month prior to adjuvant radio-chemotherapy. Patient was re-admitted at the 6th week following the last dose of radio-chemotherapy for surgery. On long-term evaluation at 10 months, the patient reported absence of symptoms with weight gain. Association of both entities is rare. Chronic inflammatory damage may possibly initiate a sequence of metaplasia and dysplasia, resulting in neoplastic transformation. Anal canal adenocarcinoma treatment follows same guidelines as rectal cancer. Extra-pulmonary tuberculosis treatment follows anti-bacillary protocol with consequent side effects. Therefore, our case is a unique clinical challenge for physicians. Management decision was multidisciplinary process. Their pathophysiology relationship is yet to be understood. Moreover, each entity has defined and individual therapeutic protocols and indications. All this taken into consideration, such case presents a clinical and therapeutic challenge for physicians.
COVID-19 related acute necrotizing encephalopathy presenting in the early postoperative period
Authors:   5th Department of Surgery, Aristotle University of Thessaloniki School of Medicine, Ippokratio General Hospital, Thessaloniki, Greece, Symeonidou Elissavet , Dimitriadou Androniki ,   "Department of Neurology, Ippokratio General Hospital, Thessaloniki, Greece", Morsi-Yeroyannis Antonios ,   5th Department of Surgery, Aristotle University of Thessaloniki School of Medicine, Ippokratio General Hospital, Thessaloniki, Greece
Published: July 2023

Besides respiratory and gastrointestinal symptoms, SARS-CoV-2 also has potential neurotropic effects. Acute hemorrhagic necrotizing encephalopathy is a rare complication of Covid-19. This article presents a case of an 81-year-old female, fully vaccinated, who underwent laparoscopic transhiatal esophagectomy due to gastroesophageal junction cancer. In the early postoperative period, the patient developed persistent fever accompanied by acute quadriplegia, impaired consciousness, and no signs of respiratory distress. Imaging with Computed Tomography and Magnetic Resonance revealed multiple bilateral lesions both in gray and white matter, as well as pulmonary embolism. Covid-19 infection was added to the differential diagnosis three weeks later, after other possible causes were excluded. The molecular test obtained at that time for coronavirus was negative. However, the high clinical suspicion index led to Covid-19 antibody testing (IgG and IgΑ), which confirmed the diagnosis. The patient was treated with corticosteroids with noticeable clinical improvement. She was discharged to a rehabilitation center. Six months later, the patient was in good general condition, although a neurological deficit was still present. This case indicates the significance of a high clinical suspicion index, based on a combination of clinical manifestations and neuroimaging, and the confirmation of the diagnosis with molecular and antibody testing. Constant awareness of a possible Covid-19 infection among hospitalized patients is mandatory.
Rapid metachronous bladder metastasis of type 2 papillary renal cell carcinoma
Authors:   Alexandria University, Alexandria, Egypt, Elabbady Ahmed , Boudreau Ryan ,   Northern Ontario School of Medicine University, Ontario, Canada, Mehrnoush Vahid ,   Northern Ontario School of Medicine University, Ontario, Canada
Published: July 2023

Renal cell carcinoma (RCC) frequently spreads to distant organs like the lung, lymph nodes, bone, and liver. However, there have been some reports of RCC bladder metastasis. We present a case of a 61-year-old man presented with total painless gross hematuria. The patient had a history of right radical nephrectomy for papillary (type 2) RCC, high-grade, pT3a with negative surgical margins. There was no evidence of metastases on 6-month surveillance CT. After one-year post-operation, at this current admission, the cystoscopy discovered a solid bladder mass away from the trigone in the right lateral bladder wall. The resected bladder mass was metastatic papillary RCC with PAX-8 positive but GATA-3 negative on immunostaining. A positron emission tomography scan confirmed multiple lung, liver, and osseous metastases. This case report can highlight the importance of having bladder metastasis in RCC mind, although rare, and may necessitate the surveillance measures like urine analysis at more frequent interval and CT Urography instead of regular CT to detect the RCC metastatic bladder cancer at early stage.
Clinical features and treatment outcomes of progressive uveal melanoma
Authors:   Clinic of Internal Diseases, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Rancelyte Milda , Pamedys Justinas ,   National Center of Pathology Affiliated to Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania, Grigiene Ruta ,   Diagnostic Radiology Department, National Cancer Institute, Vilnius, Lithuania
Published: July 2023

Uveal melanoma (UM) is a rare malignant tumor that differs from cutaneous melanoma in terms of pathogenesis, clinical behavior, and treatment response. Despite treatment for the primary tumor, 50% of UM patients develop metastatic disease, with the liver being the most affected organ. Furthermore, UM responds poorly to chemotherapy and immune checkpoint inhibitors. We present a clinical case of a 58-year-old female patient who was diagnosed with right eye choroidal melanoma cT2aN0M0. For the treatment of the initial tumor, the patient received stereotactic radiotherapy. However, 11 months after the initial diagnosis, the disease had progressed to the liver. The patient underwent radiofrequency ablation of liver metastases, then as the UM progressed - anti-PD-1 immunotherapy with nivolumab and ipilimumab were prescribed for the first-line palliative systemic treatment, later chemotherapy with dacarbazine (5 cycles) as the second-line systemic treatment. Based on the FoundationOne®CDx findings and an overview of clinical trials data, the MEK inhibitor trametinib was prescribed as a third-line palliative treatment. The patient died due to cancerous intoxication, with overall survival (OS) of 28 months (∼2.33 years) and a progression-free survival (PFS) of 11 months (∼0.92 years) since the initial diagnosis. Treatment-related adverse events could have an impact on the general health condition of the patient.
Cognitive Behavior Counseling to Improve Responsibility Attitudes: A Development of Guidebooks
Authors: Ernayanti Ni Made Desi , Dantes Nyoman , Suranata Kadek
Published: July 2023

This research was conducted to find out the procedures for implementing cognitive behavioral counseling models to improve the attitude of responsibility of high school students and to determine the validity of the contents of the cognitive behavioral counseling guide. Research conducted is research and development or research and development (R&D), the research model used is Four-D (4D). The 4D model consists of four stages of research namely define, design, develop, and disseminate. Data analysis to test the validity of the manual book product content using the Lawshe CVR and CVI formulas. Testing for products is carried out by 5 experts or experts who are competent in the field of Counseling Guidance. The results of the study based on content validity are CVR values per item +1 to 0 (CVR> 0). Thus, the results of the Lawshe CVI analysis obtained 0.79 greater than 0 (0.79> 0). Based on the analysis of these data the validity value of the contents of this guide product is high.
Resilience and Meaningfulness of Life in Broken Home Adolescents
Authors: Santoso Lia Yohana , Huwae Arthur
Published: July 2023

Living as a broken home child in adolescence tends to have a holistic adverse impact. Broken home adolescents have to go through very difficult and meaningful times. Psychologically broken home adolescents are faced with forming a strong mentality and, as much as possible, interpreting every heavy life event into a meaningful life. This study aims to determine the relationship between resilience and the meaningfulness of life of broken home adolescents. The method used is quantitative with a Spearman rho correlation design. One hundred thirty-five late adolescents aged 18-22 who were in broken homes were used as research participants using an incidental sampling technique. Research measurements used the Resilience Quotient Test (α = 0.874) and the Meaning in Life Questionnaire (α = 0.936). The results prove that resilience is positively and significantly related to the meaning of life of broken home adolescents (r = 0.304 with sig. = 0.000). Resilience contributes 9.2% to the meaningfulness of life. Applying good resilience can help increase the meaningfulness of broken-home adolescents' lives. Future research is expected to design a psychological assistance program according to the broken-home category, to facilitate broken-home adolescents to achieve a healthy life holistically.
SISTEM KENDALI KECEPATAN KONVEYOR DENGAN BEBAN BERUBAH BERBASIS HIBRID FUZZY LOGIC-PID
Authors: Abdillah Rizky
Published: July 2023

Teknologi kontrol automatik sangat dibutuhkan untuk memberikan kemudahan dalam perancangan alat kontrol. Salah satu penerapannya dalam perancangan alat pengontrol kecepatan putar motor DC pada konveyor penyortir barang. Motor listrik DC adalah alat yang dapat mengubah energi listrik menjadi energi kinetik/gerak. Sebuah motor DC membutuhkan tegangan arus searah (DC) untuk beroperasi. Tujuan dari skirpsi ini yaitu membuat pengontrol kecepatan (RPM) motor DC pada konveyor penyortir barang, mengendalikan kecepatan motor DC agar tetap terjaga kestabilan meskipun dengan beban yang berubah,  mengaplikasikan Hibrid Fuzzy Logic-PID pada pengendali kecepatan motor DC pada konveyor penyortir barang. Penelitian ini menggunakan 3 sensor sebagai feedback yaitu sensor kecepatan, sensor tegangan dan sensor arus.  Kontrol PID dibuat dengan menggunakan PID tuner pada matlab dan mendapatkan hasil parameter Kp=0,2 Ki=0,072 Kd=0,03036. Pada fuzzy logic memiliki nilai output sebanyak 5 yaitu SK =0,2 K=0,25 Sd=0,3 B=0,35 SB=0,4. Hasil penelitian menunjukansistem dapat terealisasikan, konveyor dapat tetap stabil pada setpoint dengan beban berubah sebanyak 5 kali perubahan. Pada perbandingan metode pengontrolan PID dengan Hibrid Fuzzy Logic–PID , metode PID cepat mendapatkan nilai settling time namun terjadi overshoot yang cukup tinggi , berbeda dengan Hibrid Fuzzy Logic-PID yang mendapatkan nilai settling time yang sedikit lambat namun mendapatkan hasil overshoot yang rendah.
The Effect Of Numbered Head Together (NHT) Cooperative Learning Model On Students Learning Outcomes On Human Respiratory System Materials At SMPN 2 Solok City
Authors: Sabrina Nurul , Arif Khairil
Published: July 2023

The purpose of the study was to determine the effect of the NHT (Numbered Head Together) type cooperative learning model on student learning outcomes on the human respiratory system material at SMPN 2 Solok City. This research was conducted at SMPN 2 Solok City in the 2021/2022 academic year. The type of research used is Quasi Experiment. The research design that will be used is the Non-equivalent control group design. The sampling technique used is purposive sampling. The sample used is class VIII-7 as a control class using a conventional model while class VIII-8 as an experimental class using a cooperative learning model of the NHT type. The instrument used in this study was written in the form of multiple choice questions. While the test analysis was carried out using Microsoft Excel, the calculation of the hypothesis test was carried out with the t test after conducting the prerequisite test, namely the normality test and homogeneity test. The results of the t-test calculation are tcount = 3.96 and ttable = 1.67, where tcount> ttable, thus research H0 is rejected and H1 is accepted. This shows that there is an influence on the cooperative learning model type NHT (Numbered Head Together) on the cognitive learning outcomes of class VIII students on the human respiratory system material at SMP N 2 Solok City.
Psychoeducation of Adolescent Mental Health at SMP P Malang City
Authors: Cahyani Dini
Published: July 2023

SMP P is one of the schools fostered by the Pandanwangi Health Center. Clients are students and teachers at SMP P, totaling 23 people. Based on the results of interview assessments, observations, and the depression, anxiety, and stress scale 42 (DASS 42). Based on the interview results, it is known that students and teachers at SMP P do not have knowledge related to mental health and how to deal with individuals with complaints of being stressed. The results of the DASS 42 scale screening given to 52 class VIII students showed that there were 23 students indicated to be experiencing depression, anxiety, and stress. Psychoeducation is provided in the form of delivery of material, case roleplay, relaxation exercises, discussion, and question and answer accompanied by pre-test and post-test questionnaires to measure client knowledge after and before being given psychoeducation. The purpose of providing this intervention is to increase client knowledge related to mental health in adolescents and mental health promotion. The result of the intervention was an increase in the client's knowledge about mental health before and after the intervention with a significance value of .000 (p 0.05).
Research on new ways of ideological and political education in new era universities
Authors: Chen Jing
Published: July 2023

With the advent of the scientific and technological era, the times and the modernization of China, the requirements and goals of the Political perspective applied to undergraduate universities in the Age of Science and Technology are constantly updated, and it is of practical significance to learn from a political perspective college students in the new era of rapid development today. This paper constructs the 4C/ID learning model by finding literature and methods involved and applied in the learning process to realize political learning of college students based on Internet technology and provide some theoretical reference basis for teachers and students of relevant colleges and universities. Taking the study of new ways of political learning of college students as the theoretical basis, through the support of Internet technology, the traditional research ideas discussing the political learning of college students are analyzed, discussions are held around the new ways political level learning, and finally, the 4C/ID learning model of Political learning of college students based on Internet science is constructed. How to improve the political level learning model and open up new related learning pathways is a necessary issue that educators cannot ignore today. The study shows that the 4C/ID learning model of introducing the Internet into the study of college students at the political level technology can develop political level learning to the greatest extent. Based on Internet technology, the curriculum content system political level learning can be deeply explored to promote Xi Jinping’s idea in the new social and technological era of the healthy and vigorous development of socialist culture construction.
Military Intelligence - A View Into the Future in the Light of the War in Ukraine
Authors: Rode Anže , Pavič Lojze , Ravnak Rok
Published: July 2023

Military Intelligence is one of key factors that is needed for successful warfighting on all levels. It is even more important in modern complex and rapidly changing environment. Lessons learned from War in Ukraine show that timely and accurate intelligence preparation is key to achieve battlefield dominance, especially if ratio of fighting forces is fundamentally unequal. This article presents significance of military intelligence and offer insight in some foreign defense systems/ armed forces military intelligence structures in order to improve military intelligence structure in defense system of Republic of Slovenia.