bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Micropore Structure on Macroscopic Water Cut Changing Law in Strongly Heterogeneous Reservoirs
Authors: Yang Renfeng , Jiang Ruizhong , Liu Guangwei , Chen Han , Chen Peiyuan , Sun Zhaobo
Published: November 2020

Reservoir rock type (RRT) classification is commonly used for the fine characterization of strongly heterogeneous reservoirs. Many research focused on proposing different RRT methods, while few studies focused on the relationship between micropore structure and macroscopic seepage law of fluid transporting through different types of formation. Considering the different diagenesis degrees of rock types in different sedimentary facies, the quadrant unit method and FZI method were applied to classify and evaluate the strongly heterogeneous reservoirs. The corresponding capillary pressure curves and relative permeability curves for different rock types could be obtained. A set of theoretical models that could describe the macroscopic seepage law are proposed, and numerical simulation case studies were carried out to explore the superimposed seepage law in reservoirs under different degrees of heterogeneity. Results show that water cut rises faster in poor-property RRT formation than in good-property RRT formation, with a lower recovery factor under the same conditions. The water cut rising rate increases firstly and then decreases with water cut and recovery degree increasing. The poorer the rock property is, the earlier and higher the peak value of water cut rising rate is. Also, based on numerical simulation case studies, the superimposed seepage law is close to that in the poor-property formation as the heterogeneity degree strengthens. The newly proposed method not only could provide a reference for rock type classification based on micropore structure but also could expound the influence of micropore structure on the change law of macroscopic water cut and elaborates the macroscopic change law after the superposition of different types of reservoirs. The conventional normalization of relative permeability curves is only applicable to relatively homogeneous reservoirs and not applicable to strongly heterogeneous reservoirs, especially when the permeability variation is higher than 0.7. The newly proposed approach is capable of analyzing the effect of micropore structure on macroscopic seepage law and improving the prediction accuracy of the production profile.
Prediction of α-Solanine and α-Chaconine in Potato Tubers from Hunter Color Values and VIS/NIR Spectra
Authors: Tilahun Shimeles , An Hee Sung , Hwang In Geun , Choi Jong Hang , Baek Min Woo , Choi Han Ryul , Park Do Su , Jeong Cheon Soon
Published: November 2020

The glycoalkaloids contents of potato tubers are usually measured by the destructive analysis that consumes time and requires expensive high-performance equipment. This study was carried out to determine the possibility of nondestructive estimation of α-solanine and α-chaconine content in potato tubers. Visible/near-infrared (VIS/NIR) spectra, color values, and the reference α-solanine and α-chaconine were measured from 180 tubers of ‘Atlantic’ and ‘Trent’ potato cultivars with eight replications at two-week intervals during the storage up to ten weeks. The partial least square (PLS) regression method was used to develop models correlating color and spectra data to the measured reference data. Regression coefficient (r) between color variables (Hunter

a

∗

,

a

∗

/

b

∗

, and (

a

∗

/

b

∗

)2) and the actual measured values of a-solanine and a-chaconine content were 0.74, 0.62, and 0.62 and 0.70, 0.58, and 0.57, respectively, for the prediction set. Concurrently, equations were developed from color variables in multiple regression with r-values of 0.76 and 0.71 for α-solanine and α-chaconine, respectively. Additionally, the selected PLS model of VIS/NIR spectra had promising predictive power for α-solanine and α-chaconine with r-values of 0.68 and 0.63, respectively, between measured and predicted samples. Taken together, although it requires further studies to improve the prediction power of the developed models, the results of this study revealed the possibility of using VIS/NIR spectra and color variables for the prediction of α-solanine and α-chaconine contents from intact unpeeled potato tubers with chemical-free, fast, and cheap assessment methods.
Influence of the Interfacial Properties on the Stability of Water in Heavy Oil Emulsions in Thermal Recovery Process
Authors: Sun Yongtao , Li Zhaomin
Published: November 2020

Under the conditions of thermal oil recovery, the heavy oil in a reservoir usually exists in the form of W/O emulsion with high water content, which has significant effect on oil recovery performance. The most important parameter on the stability of W/O emulsion is interfacial properties. Thus, in order to investigate the effect of interfacial properties on the stability of W/O emulsion in a heavy oil reservoir at elevated temperatures, experiments have been conducted to generate various emulsions with variations in the temperature; stirring rate; contents of asphaltene, resin, and wax of the simulated heavy oil; and water salinity based on a target heavy oil reservoir in China. Then, the properties of the W/O emulsions include viscosity, interfacial viscosity (IFV), interfacial tension (IFT), and dehydration rate; the microscopic morphologies are measured as well. The experimental results show evidently stable W/O emulsion of heavy oil and water generated in thermal processes due to the stable, thick, and indistinct interface between heavy oil and water, where the active molecules of asphaltene and resin are accumulated. The interface connects the central large droplet and the surrounding small droplets tightly. The results also indicate the size of the central droplet, and the indistinct interface can be enlarged with increasing temperature and increasing stirring rate. Compared to resin, it is noted that the larger asphaltene molecules have stronger connection because of their stronger intermolecular force, larger IFV, and less IFT. At the same time, the stability of W/O emulsion will be strengthened with increasing temperature and stirring rate and gradually weakened with increasing salinity. In conclusion, the stability of water in heavy oil emulsion is mainly related to the large interfacial viscosity of the interface with much more heavy components such as asphaltene and resin compared to thin oil.
Research on a Miniature Multiparameter Water Quality Sensor Chip and a System with a Temperature Compensation Function
Authors: Wang Xin , Sun Lining , Shi Yunbo
Published: November 2020

This paper presents a multiparameter water quality sensor chip with temperature compensation. The sensor chip was manufactured using microelectromechanical system (MEMS) technology. The surface of the chip integrated pH, dissolved oxygen (DO), ammonia nitrogen, and temperature sensors. To compensate for the solution temperature, the chip was also designed with a sandwich, plate-type serpentine Pt resistance heater. The experimental results showed that the pH sensor had a high sensitivity of 0.288 mA/pH with good linearity (

R

2

=
0.9998

), the sensitivity of the temperature sensor was 0.949 Ω/°C, the sensitivity of the ammonia nitrogen sensor was 0.1139 mA/ppm, the sensitivity of the dissolved oxygen (DO) sensor was 2.22 μA/ppm, and the sensitivity of the temperature changes with respect to the heater power was 0.3126°C/mW. Compared with a single water quality parameter sensor, the as-prepared sensor chip could simultaneously detect multiple parameters of a water sample and had a good temperature compensation effect. Moreover, the sensor chip was small in size, rugged, and highly accurate.
Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo
Authors: Anastasiadou Eleni , Seto Anita G. , Beatty Xuan , Hermreck Melanie , Gilles Maud-Emmanuelle , Stroopinsky Dina , Pinter-Brown Lauren C. , Pestano Linda , Marchese Cinzia , Avigan David , Trivedi Pankaj , Escolar Diana M. , Jackson Aimee L. , Slack Frank J.
Published: November 2020

Purpose:

miRNA-155 is an oncogenic miRNA highly expressed in B-cell malignancies, particularly in the non–germinal center B-cell or activated B-cell subtype of diffuse large B-cell lymphoma (ABC-DLBCL), where it is considered a potential diagnostic and prognostic biomarker. Thus, miR-155 inhibition represents an important therapeutic strategy for B-cell lymphomas. In this study, we tested the efficacy and pharmacodynamic activity of an oligonucleotide inhibitor of miR-155, cobomarsen, in ABC-DLBCL cell lines and in corresponding xenograft mouse models. In addition, we assessed the therapeutic efficacy and safety of cobomarsen in a patient diagnosed with aggressive ABC-DLBCL.

Experimental Design:

Preclinical studies included the delivery of cobomarsen to highly miR-155–expressing ABC-DLBCL cell lines to assess any phenotypic changes, as well as intravenous injections of cobomarsen in NSG mice carrying ABC-DLBCL xenografts, to study tumor growth and pharmacodynamics of the compound over time. To begin to test its safety and therapeutic efficacy, a patient was recruited who underwent five cycles of cobomarsen treatment.

Results:

Cobomarsen decreased cell proliferation and induced apoptosis in ABC-DLBCL cell lines. Intravenous administration of cobomarsen in a xenograft NSG mouse model of ABC-DLBCL reduced tumor volume, triggered apoptosis, and derepressed direct miR-155 target genes. Finally, the compound reduced and stabilized tumor growth without any toxic effects for the patient.

Conclusions:

Our findings support the potential therapeutic application of cobomarsen in ABC-DLBCL and other types of lymphoma with elevated miR-155 expression.
Randomized Phase II Trial of Anthracycline-free and Anthracycline-containing Neoadjuvant Carboplatin Chemotherapy Regimens in Stage I–III Triple-negative Breast Cancer (NeoSTOP)
Authors: Sharma Priyanka , Kimler Bruce F. , O'Dea Anne , Nye Lauren , Wang Yen Y. , Yoder Rachel , Staley Joshua M. , Prochaska Lindsey , Wagner Jamie , Amin Amanda L. , Larson Kelsey , Balanoff Christa , Elia Manana , Crane Gregory , Madhusudhana Sheshadri , Hoffmann Marc , Sheehan Maureen , Rodriguez Roberto , Finke Karissa , Shah Rajvi , Satelli Deepti , Shrestha Anuj , Beck Larry , McKittrick Richard , Pluenneke Robert , Raja Vinay , Beeki Venkatadri , Corum Larry , Heldstab Jaimie , LaFaver Stephanie , Prager Micki , Phadnis Milind , Mudaranthakam Dinesh Pal , Jensen Roy A. , Godwin Andrew K. , Salgado Roberto , Mehta Kathan , Khan Qamar
Published: November 2020

Purpose:

Addition of carboplatin (Cb) to anthracycline chemotherapy improves pathologic complete response (pCR), and carboplatin plus taxane regimens also yield encouraging pCR rates in triple-negative breast cancer (TNBC). Aim of the NeoSTOP multisite randomized phase II trial was to assess efficacy of anthracycline-free and anthracycline-containing neoadjuvant carboplatin regimens.

Patients and Methods:

Patients aged ≥18 years with stage I–III TNBC were randomized (1:1) to receive either paclitaxel (P) weekly × 12 plus carboplatin AUC6 every 21 days × 4 followed by doxorubicin/cyclophosphamide (AC) every 14 days × 4 (CbP → AC, arm A), or carboplatin AUC6 + docetaxel (D) every 21 days × 6 (CbD, arm B). Stromal tumor-infiltrating lymphocytes (sTIL) were assessed. Primary endpoint was pCR in breast and axilla. Other endpoints included residual cancer burden (RCB), toxicity, cost, and event-free (EFS) and overall survival (OS).

Results:

One hundred patients were randomized; arm A (n = 48) or arm B (n = 52). pCR was 54% [95% confidence interval (CI), 40%–69%] in arm A and 54% (95% CI, 40%–68%) in arm B. RCB 0+I rate was 67% in both arms. Median sTIL density was numerically higher in those with pCR compared with those with residual disease (20% vs. 5%; P = 0.25). At median follow-up of 38 months, EFS and OS were similar in the two arms. Grade 3/4 adverse events were more common in arm A compared with arm B, with the most notable differences in neutropenia (60% vs. 8%; P < 0.001) and febrile neutropenia (19% vs. 0%; P < 0.001). There was one treatment-related death (arm A) due to acute leukemia. Mean treatment cost was lower for arm B compared with arm A (P = 0.02).

Conclusions:

The two-drug CbD regimen yielded pCR, RCB 0+I, and survival rates similar to the four-drug regimen of CbP → AC, but with a more favorable toxicity profile and lower treatment-associated cost.
The Bromodomain Inhibitor PFI-3 Sensitizes Cancer Cells to DNA Damage by Targeting SWI/SNF
Authors: Lee Daye , Lee Da-Yeon , Hwang You-Son , Seo Hye-Ran , Lee Shin-Ai , Kwon Jongbum
Published: November 2020

Many chemotherapeutic drugs produce double-strand breaks (DSB) on cancer cell DNA, thereby inducing cell death. However, the DNA damage response (DDR) enables cancer cells to overcome DNA damage and escape cell death, often leading to therapeutic resistance and unsuccessful outcomes. It is therefore important to develop inhibitors that target DDR proteins to render cancer cells hypersensitive to DNA damage. Here, we investigated the applicability of PFI-3, a recently developed bromodomain inhibitor specifically targeting the SWI/SNF chromatin remodeler that functions to promote DSB repair, in cancer treatment. We verified that PFI-3 effectively blocks chromatin binding of its target bromodomains and dissociates the corresponding SWI/SNF proteins from chromatin. We then found that, while having little toxicity as a single agent, PFI-3 synergistically sensitizes several human cancer cell lines to DNA damage induced by chemotherapeutic drugs such as doxorubicin. This PFI-3 activity occurs only for the cancer cells that require SWI/SNF for DNA repair. Our mechanism studies show that PFI-3 exerts the DNA damage–sensitizing effect by directly blocking SWI/SNF's chromatin binding, which leads to defects in DSB repair and aberrations in damage checkpoints, eventually resulting in increase of cell death primarily via necrosis and senescence. This work therefore demonstrates the activity of PFI-3 to sensitize cancer cells to DNA damage and its mechanism of action via SWI/SNF targeting, providing an experimental rationale for developing PFI-3 as a sensitizing agent in cancer chemotherapy.

Implications:

This study, revealing the activity of PFI-3 to sensitize cancer cells to chemotherapeutic drugs, provides an experimental rationale for developing this bromodomain inhibitor as a sensitizing agent in cancer chemotherapy.
As adaptações na capacidade aeróbia não são transferidas para a capacidade de sprints repetitivos
Authors: Kalva-Filho Carlos Augusto , Loures João Paulo , Redkva Paulo Eduardo , Zagatto Alessandro Moura , Papoti Marcelo
Published: November 2020

No presente estudo, objetivou-se testar se a melhora da capacidade aeróbia, observada após oito semanas de treinamento, é transferida para a capacidade de sprints repetitivos (CSR). Dez corredores (18 ± 1 ano; estatura de 170,1 ± 8,0 cm; massa corporal de 66,4 ± 6,6 kg) participaram do estudo. A capacidade aeróbia foi considerada como a intensidade correspondente à concentração de 4 mM de lactato (OBLA), determinada durante teste incremental, realizado em pista de atletismo. A capacidade de sprints repetitivos foi avaliada por meio de seis sprints de 35 m, separados por dez segundos de intervalo passivo. Todos os testes foram aplicados antes e após oito semanas de treinamento polarizado. Os efeitos do treinamento foram evidenciados por meio do teste t de Student para amostras dependentes, e as possíveis relações entre as alterações percentuais do OBLA e a CSR foram verificadas pelo teste de correlação de Pearson. Para todas as análises o nível de significância foi de p < 0,05. Após o treinamento, todos os participantes apresentaram aumento significativo da intensidade de OBLA (antes 15,4 ± 0,9 km·h-1; após 17,2 ± 1,6 km·h-1; p = 0,01). Na avaliação da CSR, constatou-se que a velocidade máxima, a velocidade média e o índice de fadiga não foram modificados com o treinamento (p > 0,61). Nenhuma correlação foi observada entre as alterações percentuais da intensidade de OBLA e as alterações das variáveis relacionadas à capacidade de sprints repetitivos (r < – 0,26; p > 0,47). Assim, esses resultados demonstram que a melhora da capacidade aeróbia não é transferida para a CSR, avaliada por meio de seis esforços, separados por dez segundos de intervalo passivo.
Efeito agudo de dois modelos de treinamento intervalado sobre a carga interna em atletas de futsal feminino
Authors: Silva Telmo Nunes da , Nunes Renan Felipe , Serpa Marília Cavalcanti , Coelho Tiago Martins , Guglielmo Luiz Guilherme
Published: November 2020

O objetivo desse estudo foi analisar o efeito agudo em duas sessões de treinamento intervalado de alta intensidade (TIAI) sobre os valores de carga interna em atletas de futsal feminino. Treze jogadoras adultas (21,2±2,8 anos; 60,3±7,6 kg; 163±06 cm; 20,6%±5,7 gordura) foram submetidas a quatro sessões experimentais: 1) Antropometria e teste incremental em esteira rolante (TIER); 2) Futsal Intermittent Endurance Test (FIET); 3) Maximal Shuttle Run Test (40-m MST); 4) divididas randomicamente em dois grupos, aonde cada grupo completou um dos dois modelos de TIAI em duas sessões de treinamento, consistindo em 8 séries similares em relação esforço:pausa (1:1), distância relativa (m.min-1) de modo que gerasse a mesma intensidade de corrida relativa ao PV do FIET (100% do Pico de Velocidade), mas com número de mudanças de direção distintos (TIAI7,5x7,5=1 vs. TIAI15x15=3). Lactato sanguíneo (Lac), frequência cardíaca (FC) e percepção subjetiva de esforço (PSE) foram coletados. Não foram encontradas diferenças nas variáveis obtidas no TIER, FIET, 40-m MST e entre as médias de FC e PSE durante TIAI entre os grupos (p>0,05). Porém, mudanças foram reportadas ao longo do tempo para FC (F=15,207; p<0,05) e [Lac] (F=57,110; p<0,001) em ambos os grupos. Valores de [Lac] foram superiores no TIAI7,5x7,5 comparado ao TIAI15x15 na série 1 (F(2,28)=2,234; p<0,05), além disso, a análise de inferência demonstrou valores muito provavelmente maiores na série 1 (98/1/1) e provavelmente maiores na série 2 (93/5/2) ambos com grande tamanho do efeito(TE=1,31; TE=0,84). Com base nos resultados obtidos em uma sessão de treino, conclui-se que os ambos os modelos de TIAI são capazes de promover mudanças na carga interna em jogadoras de futsal em uma mesma proposta de sessão de treino.
C-reactive protein is inversely and independently associated with maximal oxygen uptake in adolescents with obesity
Authors: Nunes João Elias Dias , Cunha Heitor Santos , Teixeira Renata Roland , Espindola Foued S. , Cheik Nádia Carla
Published: November 2020

The purposes of this study were: 1) investigate whether different markers of infl ammation (CRP and TNF-alpha) are correlated to cardiorespiratory fi tness in adolescents with obesity; 2) examine the association of these variables when adjusted by parameters of body composition. Were selected 57 individuals, 34 girls and 23 boys, with 16.4±1.56 years and body mass index 36.0±4.3 kg/m2. Anthropometric measurements (weight, height and abdominal circunference) and body composition (BMI, visceral fat, body fat) were assessment. Body composition was estimated by analyzer of tetrapolar bioelectrical impedance. Obesity was defi ned as BMI>95th percentile of the curve proposed by the Center for Diseases Control. Plasma TNF-alpha was measured by a quantitative two-site high-sensitivity enzyme immunoassay and CRP was measured by high-sensitivityimmunoturbidimetric assay. Graded maximal exercise testing was performed to obtain the maximum oxygen consumption (VO2max) and velocity associated with the VO2max (vVO2max). Signifi cant correlations of CRP with VO2max and vVO2max were found (r=-0.40 and r=-0,36, respectively). No correlations were observed between TNF-alpha and VO2max e vVO2max. CRP was associated to the VO2max and vVO2max independently of measurements of body composition. The CRP was independently and inversely associated with direct measurement of VO2max and the indirect variable of cardiorespiratory fitness vVO2max, in obese adolescents, even after adjustments in body composition, a potential confounding factor. No association was found between TNF-alpha and the parameters of cardiorespiratory fitness.
Revisão crítica da literatura brasileira sobre as coberturas jornalísticas esportivas do futebol feminino
Authors: Gabriel Bruno José , Paula Erica Fernanda de , Pedroso Bruno , Freitas Junior Miguel Archanjo de , Pinto Márcia Helena Baldani
Published: November 2020

Os objetivos deste artigo foram revisar e analisar criticamente a estruturação da literatura, publicada em periódicos científicos nacionais, que estabeleceu as coberturas jornalísticas impressas e digitais acerca do futebol feminino e das jogadoras como objeto de estudo. Para tanto, optou-se pela adoção dos direcionamentos da Revisão Crítica, complementados pelos instrumentos metodológicos da Análise de Conteúdo, pois estes guiam os pesquisadores no processo analítico dos diversos tipos de discursos, dentre estes, o acadêmico/científico. Após a análise crítica dos seis artigos encontrados, chegou-se a três considerações preponderantes, nomeadamente, insufi ciência na apresentação das escolhas metodológicas, diálogo interdisciplinar insuficiente, sobretudo com as teorias do jornalismo, e necessidade de pesquisas complementares.
Rádio regional: um patrimônio cultural imaterial e um lugar de memória
Authors: Coutinho Elane Gomes Santos
Published: November 2020

O rádio faz parte da história e da cultura de diversas regiões do Brasil. Na forma representativa com que se relaciona com estas culturas, o rádio regional, em especial, pode ser considerado como patrimônio cultural imaterial e lugar de memória. Isso vemos acontecer no programa Ranchinho do Jajá, da Rádio Mantiqueira AM 550 de Cruzeiro-SP, objeto deste artigo, que traz como objetivo analisar como os conceitos de patrimônio cultural imaterial e lugar de memória podem ser aplicados ao rádio. Seguindo a abordagem qualitativa, utiliza a estratégia de análise de conteúdo dos comentários de ouvintes do programa. Os resultados mostram que os conceitos de patrimônio cultural e lugar de memória podem ser aplicados ao rádio, a partir do sentido que a recepção dá para o seu conteúdo e seus elementos. A pesquisa contribui, portanto, com os estudos sobre o rádio como patrimônio cultural imaterial.
"Milagre dos peixes": a censura e a voz de Milton Nascimento na sociedade do espetáculo brasileira
Authors: Coan Emerson Ike
Published: November 2020

O artigo versa sobre a produção cultural de Milton Nascimento, com vistas a uma compreensão das características da sociedade brasileira contemporânea, numa investigação de seu processo histórico e na perspectiva da sociedade do espetáculo, em especial no contexto musical e pol´ítico do Brasil em 1973, quando lançado o álbum "Milagre dos Peixes". Este álbum é uma obra de arte sobrevivente aos ataques da censura no período da ditadura militar.
Os loucos estão soltos e as pontes estão caindo
Authors: Vieira Marina Cavalcante
Published: November 2020

Gotham City e Metrópolis figuram entre as cidades imaginárias mais famosas do universo das histórias em quadrinhos. Criadas nos Estados Unidos em finais da década de 1930, elas são mais do que simples cenários para as aventuras do Batman e Super-Homem, são cidades ficcionais que refletem as questões vividas pelos grandes centros urbanos da época. O presente artigo debruça-se sobre a representação das cidades do Batman e SuperHomem, tomando como objeto de pesquisa a questão do crime e problemas urbanos nas primeiras histórias destes dois super-heróis, do período de 1938 a 1941.
Editorial
Authors: Vergueiro Waldomiro , Santos Roberto Elísio dos
Published: November 2020

Apresenta os artigos que compõem o primeiro fascículo do volume 8 da revista 9a Arte.
Significações imaginárias do humor nos quadrinhos de Conceição Cahú
Authors: Pessoa Alberto Ricardo
Published: November 2020

O artigo disserta acerca das significações imaginárias do humor no quadrinhos Uma História de Amor, premiada no 19º Salão de Humor de Piracicaba, de autoria de Conceição Cahú que assim como outras autoras foram esquecidas entre os pesquisadores e são desconsideradas como pioneiras em representações gráficas sequenciais com uma maneira peculiar de construção do humor e seu reflexo no cotidiano da sociedade. Conceição Cahú apresenta em sua obra um humor calcado no empoderamento social, na  sexualidade e em sua própria biografia, com uma estética narrativa que ressoa entre artistas do mais variados gêneros. A nossa hipótese é que Conceição Cahú aponta em um discurso humorístico com traços ingênuos, grotescos e com diálogo de contraponto constante com os estereótipos femininos criados por autores masculinos. Apresentamos uma introdução à autora, contexto social do qual se desenvolve como quadrinista e o legado criativo para as histórias em quadrinhos.
Humor e ensino: reflexões necessárias
Authors: Gatti Márcio Antônio
Published: November 2020

Apresenta a resenha do livro Gêneros humorísticos em análise, organizado por Ana Cristina Marcelino e Paulo Ramos.
O Livro de Falas no Brasil e nos E.U.A: percursos literários e tradutórios
Authors: Mello Giovana Cordeiro Campos de
Published: November 2020

O objetivo deste trabalho é refletir, a partir de um prisma historiográfico e cultural, sobre o processo de publicação de O Livro de Falas ou Kalunbungu, de Edimilson de Almeida Pereira, no Brasil, em 1987, em edição do autor, e nos Estados Unidos, na revista Callaloo, em 1996. A voz do poeta começou seu caminho em 1985, com Dormundo, seguido pela publicação de O Livro de Falas, e continuou seu percurso com a publicação de poesias, ensaios e literatura infantojuvenil, entre outros, tendo o universo afro-brasileiro como tema de reflexão. Os textos do referido pesquisador, ensaísta e poeta conseguiram extrapolar as fronteiras nacionais, tendo sido traduzidos e publicados em países como a Inglaterra, Itália, Espanha Alemanha e Estados Unidos. A presente pesquisa ilumina parte dessa trajetória, tomando como base conceitos dos Estudos da Tradução e procurando pensar a tradução de elementos da cultura brasileira para o contexto norte-americano e o processo mais amplo da publicação de poesia afro-brasileira em solo nacional e estrangeiro.
Entre ingredientes, cozinhas e afetos: aspectos socioculturais de uma vida dedicada à comida
Authors: Altoé Isabella , Azevedo Elaine de
Published: November 2020

É possível afirmar que, em alguma medida, todos os seres humanos são afetados pela culinária. Entre diferentes intensidades de afinidade com a comida, há um grupo que se destaca por nutrir uma relação mais intensa com a alimentação: os cozinheiros. Cozinheiras e cozinheiros podem ser vistos como humanos que trilham suas vidas junto à dos alimentos e dedicam-se a eles diariamente. Essa caminhada conjunta faz parte de uma jornada de vidas construída historicamente, composta por muitos momentos de experiência culinária, bem como por diversos aspectos simbólicos e culturais que antecedem a vivência dentro da cozinha. Nesse sentido, voltar a atenção para questões socioculturais e simbólicas que englobam a alimentação é essencial para compreender como a relação entre cozinheiros e culinária é formada. Cozinheiros não nasceram com uma conexão inata com os alimentos, eles criaram um poderoso afeto pela comida ao longo de suas vidas. Sendo assim, como é estabelecida esta íntima relação entre humanos que cozinham e a culinária? Quais aspectos socioculturais e simbólicos ajudam a construir essa rede de afetos? Este artigo se volta à análise teórica de três aspectos considerados importantes para essa relação: a memória, a comensalidade e o afeto. A comida deixa trilhas na vida dos seres humanos; cria memórias poderosas nos imaginários, convoca pessoas para o convívio e evoca sentimentos duradouros. Relatar esses aspectos mais abrangentes da alimentação é descrever uma parte da história da comida fundamental para todos os seres humanos, em especial, os cozinheiros.
Burn the Place: A Memoir, uma resenha
Authors: Lazzarotto Arthur Romanzini , Schell Deise Cristina
Published: November 2020

Esta resenha aborda a recente obra de Iliana Regan, Burn the Place: A Memoir. Regan é uma cheffe de cozinha norte-americana que publicou suas memórias narrando sua vida e o que a levou a ser cozinheira de modo singular e inspirador. A obra apresenta diversos tópicos da vida contemporânea discutidos em torno da alimentação e da gastronomia, como memória, afetividade, tradição, sexismo, abuso de drogas, criatividade e gestão de pessoas. Trata-se de um livro que poderá ser base bibliográfica para trabalhos e debates futuros que abordem estas questões.
Rede de conhecimento sobre a produção quilombola de alimentos no IFSP Campus Registro: cultura e tradição alimentar
Authors: Nepomuceno Iamara de Almeida , Aragi Juliana Cesário
Published: November 2020

O Vale do Ribeira está entre as áreas de maior preservação da Mata Atlântica e, neste bioma, habitam cerca de 80 comunidades quilombolas que praticam a agricultura de coivara itinerante. O Sistema Agrícola Tradicional Quilombola (SAT) define-se por conhecimentos aplicados na agricultura de subsistência, na medicina, na cultura material e nas organizações de trabalho. Com iniciativas como o Programa Nacional de Alimentação Escolar (PNAE) e o Programa de Aquisição de Alimentos (PAA), existem melhores condições de manutenção dos meios e modos de vida das comunidades quilombolas, garantindo maior autonomia e a permanência na terra. Nesta pesquisa, buscamos compreender em que medida os esforços realizados pelo campus Registro do Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP) em relação a esses programas podem ajudar na ampliação do conhecimento dessas tradições no âmbito institucional. Analisamos fontes orais, com base no método da História Oral, abordando-as a partir de conceitos de “identidade” e “memória”, além de documentos produzidos para o reconhecimento do SAT como Patrimônio Imaterial Brasileiro (Dossiê SAT e Inventário Cultural Quilombola). Realizamos ainda projeto junto aos estudantes do quilombo de Sapatu, presentes no campus, o que resultou na aproximação dos demais alunos com a realidade quilombola, na valorização do consumo de alimentos in natura, sem agrotóxicos, e no estímulo a parcerias nos processos de compras institucionais de alimentos – um exemplo foi a banana fornecida em 2019 pelo PNAE, que adveio do referido quilombo.
Abstract 16356: Higher Mortality Up to 36 Months in ST-Segment Elevation Myocardial Infarction Patients Without Standard Modifiable Risk Factors: Results From the SWEDEHEART Registry
Authors: Figtree Gemma A , Vernon Stephen T , Hadziosmanovic Nermin , Sundstrom Johan , Alfredsson Joakim , Leosdottir Margret , Hagstrom Emil
Published: November 2020

Introduction:
While prevention strategies that target
S
tandard
M
odifiable cardiovasc
u
lar
R
isk
F
actors (SMuRFs: hypertension, diabetes mellitus, hypercholesterolemia, smoking) are critical to reduce coronary heart disease risk, myocardial infarction (MI) in the absence of SMuRFs is not infrequent.

Methods:
We examined the presenting features, treatment, short- and long-term outcomes of patients with ST-segment-elevation MI (STEMI) without SMuRFs compared to STEMI patients with >0 SMuRFs in the national Swedish MI registry SWEDEHEART between 2006-2018. Adjusted logistic regression models were used to determine outcome predictors of all cause 30-day mortality. Kaplan Meir survival analysis was performed.

Results:
8,400 (14%) of 60,692 patients without a history of coronary artery disease had no SMuRFs. Patients with and without SMuRFs had the same rate of primary PCI but lower rate of multivessel disease (37% vs. 44%). SMuRF-less patients had higher rates of unadjusted all-cause mortality at 30 days (12% vs. 8%, P <0.0001) and at 36 months (20% vs. 17%, P <0.0001). In adjusted models, having SMuRFs vs. being SMuRF-less (OR 0.63 [95% CI 0.54-0.73]), female sex, LVEF <40%, pre-hospital cardiac arrest, higher heart rate and creatinine, and lower systolic blood pressure were predictors of 30-day mortality (P <0.0001 for all). All-cause mortality rate at 30 days was highest among SMuRF-less females and those with LVEF <40% (Figure 1). The proportion on preventive pharmacotherapy at discharge was lower in SMuRF-less patients.

Conclusions:
14% of STEMI presentations occurred in the absence of SMuRFs. Higher rates of 30-day mortality in SMuRF-less STEMI patients, especially among women, highlight the need for improved risk stratification and evidence-based pharmacotherapy during the post MI period, irrespective of baseline risk factors and sex.

Figure 1.
Kaplan Meier survival curves for patients with and without SMuRFs. A) Women. B) Men. C) LVEF < 40%. D) LVEF > 40%.
Glucose Metabolism in the Kidney: Neurohormonal Activation and Heart Failure Development
Authors: Gronda Edoardo , Jessup Mariell , Iacoviello Massimo , Palazzuoli Alberto , Napoli Claudio
Published: November 2020

The liver is not the exclusive site of glucose production in humans in the postabsorptive state. Robust data support that the kidney is capable of gluconeogenesis and studies have demonstrated that renal glucose production can increase systemic glucose production. The kidney has a role in maintaining glucose body balance, not only as an organ for gluconeogenesis but by using glucose as a metabolic substrate. The kidneys reabsorb filtered glucose through the sodium‐glucose cotransporters sodium‐glucose cotransporter (SGLT) 1 and SGLT2, which are localized on the brush border membrane of the early proximal tubule with immune detection of their expression in the tubularized Bowman capsule. In patients with diabetes mellitus, the renal maximum glucose reabsorptive capacity, and the threshold for glucose passage into the urine, are higher and contribute to the hyperglycemic state. The administration of SGLT2 inhibitors to patients with diabetes mellitus enhances sodium and glucose excretion, leading to a reduction of the glycosuria threshold and tubular maximal transport of glucose. The net effects of SGLT2 inhibition are to drive a reduction in plasma glucose levels, improving insulin secretion and sensitivity. The benefit of SGLT2 inhibitors goes beyond glycemic control, since inhibition of renal glucose reabsorption affects blood pressure and improves the hemodynamic profile and the tubule glomerular feedback. This action acts to rebalance the dense macula response by restoring adenosine production and restraining renin‐angiotensin‐aldosterone activation. By improving renal and cardiovascular function, we explain the impressive reduction in adverse outcomes associated with heart failure supporting the current clinical perspective.
The Greek language in Sicily between the Hellenistic Period and Late Antiquity: A contribution from an epigraphic corpus
Authors: Capano Marta
Published: November 2020

My PhD dissertation (Università degli Studi di Napoli L’Orientale), entitled “Il greco in Sicilia fra età ellenistica e tarda antichità. Un contributo da un corpus epigrafico” (transl. “The Greek language in Sicily between the Hellenistic Period and Late Antiquity. A contribution from an epigraphic corpus”) offers a comprehensive analysis of the Greek language in post-classical Sicilian inscriptions, paying specific attention to the contact with other languages—especially Latin—and to the lexical and formulaic specificities of Christian epigraphy.
Why Are You Talking Like That, Sir? Il-Limbi, Phonology and Class in Contemporary Egypt
Authors: Youssef Islam
Published: November 2020

This article investigates the phonological patternings in the speech of il-Limbi, an immensely popular character in Egyptian comedy; and it stands therefore at a crossroads between cultural studies and linguistics. Il-Limbi represents the urban working classes, and his speech often mocks social conventions through ludicrous parody of educated speech. Masquerading as socially superior personas, his speech highlights the diglossic situation in Egypt as well as the pretentious use of English into the elite register. My examination of il-Limbi’s pronunciation in four movies reveals a number of systematic patterns in both consonants and vowels, which construct a unique code. This code is based partly on exaggerated features of Cairene Arabic and partly on genuine features of illiterate, lower-class vernacular. And it is often the interplay between various registers via correspondence rules that creates humor in the films.
Maps, Language, and the Conceptual–Non-Conceptual Distinction
Authors: Aguilera Mariela , Castellano Federico
Published: November 2020

To make the case for non-conceptualism, Heck (2007) draws on an apparent dichotomy between linguistic and iconic representations. According to Heck, whereas linguistic representations have conceptual content, the content of iconic representations is non-conceptual. Based on the case of cartographic systems, the authors criticize Heck’s dichotomous distinction. They argue that maps are composed of semantically arbitrary elements that play different syntactic roles. Based on this, they claim that maps have a predicative structure and convey conceptual content. Finally, the authors argue that, despite their differences, maps and sentences can logically interact with each other through heterogeneous inferences. These considerations not only challenge the view that conceptual content and inferential processes necessarily involve linguistic representations; furthermore, they provide a new perspective for thinking about maps, their semantics and syntax, and their interaction with linguistic systems.
Leibniz’s Inductive Challenge
Authors: Pelletier Arnaud
Published: November 2020

Leibniz’s metaphysics is often interpreted as being based solely on reason, so that experience would not provide a true foundation but only an analogy to it. Against this reading, this article first recalls that, according to Leibniz, experiences are necessarily implied by the demonstrative nature of metaphysics, for they take the place of an infinite chain of demonstrative steps that we cannot explain. It then argues that what he calls the two “first experiences” – namely, that “I think” and “a variety of things are always thought by me” – play a decisive role in justifying the Monadology’s key propositions that “there are substances” and “there are composites”. Although Leibniz never uses the term induction in this context, this – often neglected – role of singular first-person experiences in the grasping of universal propositions constitutes a real inductive moment in his metaphysics.
Responsibility of the United Nations for Wrongful Acts Occurred in the Framework of Authorized Operations in Light of the Draft Articles on the Responsibility of International Organizations (dario)
Authors: Lozanorios Frédérique
Published: November 2020

When the Security Council authorizes a State or an international organization to use force, it entrusts it with authority over the chain of command of the operation. That is why the un has always declined to assume responsibility for conduct occurring in the context such operations. While this position is widely supported by practice, and by the 2011 Draft Articles on the Responsibility of International Organizations (dario) of the International Law Commission (ilc), certain cases brought before the European Court of Human Rights (ECtHR) such as Behrami/Saramati have challenged this principle. These cases had the merit of bringing to the fore uncertainties about the rules of responsibility applicable to complex schemes of peacekeeping. This study aims to address the question: in the light of the dario, to what extent could responsibility be attributed to the un for conduct occurred in the framework of authorized operations, and what kind of responsibility would that be?

First, it argues that no basis can be found in the principles of independent responsibility to justify the attribution of wrongful conduct committed on the occasion of authorized operations to the un, unless in exceptional factual circumstances. Second, it contends that indirect responsibility could be an appropriate way to apprehend the specific relationships established between the un on the one hand and the operations it has authorized on the other hand.
Rule of Law and the Sustainable Development Goals
Authors: Wiik Astrid , Lachenmann Frauke
Published: November 2020

2015 is the year when the Millennium Development Goals are due to be achieved. Deliberations about a post-2015 agenda have been ongoing for years, with multiple un agencies, ngos, and other stakeholders participating. The Open Working Group (owg) of the General Assembly in 2014, after a complex procedure, presented a proposal on the sdgs that will serve as the basis for Member State negotiations in 2015. The paper seeks to outline the organizational challenges of a process that was intended to be inclusive like none before, but that seems to have proved overwhelming, even detrimental to the objective. It does so by showing how, in the case of the rule of law concept, hopes were raised and then disappointed.
Two new species of Heliantheae (Asteraceae) from Serra do Cabral, Minas Gerais, Brazil

Authors: BUENO VINICIUS R. , NAKAJIMA JIMI N.
Published: November 2020

The floristic inventory carried out for Heliantheae s.l. from Serra do Cabral, Minas Gerais, Brazil, revealed two new species: Dimerostemma scabrosum characterized by its leaves ovate and scabrous, heads solitary or in pairs, pappus 4-aristate in ray flowers and 2-aristate in disc flowers; and Wedelia tenuifolia characterized by its leaves narrow, heads solitary or in pairs, peduncle long, and involucre 4–5-seriate. Descriptions, illustrations, phenological and geographic data of these species are presented.
Review of the Neotropical genus Pseudosympycnus (Diptera: Dolichopodidae), with description of six new species from Brazil and Peru
Authors: SOARES MATHEUS M. M. , CAPELLARI RENATO S.
Published: November 2020

The Neotropical stolidosomatine genus Pseudosympycnus Robinson (Diptera: Dolichopodidae) is reviewed and contains 12 species, including six new species that herein are described and illustrated: P. araza sp. nov. (Peru, department of Cusco), P. bickeli sp. nov. (Brazilian States of Pará and Roraima), P. latitibia sp. nov. (Brazilian States of Minas Gerais, Rio de Janeiro and São Paulo), P. maroaga sp. nov (Brazilian State of Amazonas), P. robinsoni sp. nov. (Brazilian State of Acre), and P. sehnali sp. nov. (Brazilian State of Amazonas). All species are diagnosed, male and female terminalia of the genus are illustrated for the first time, high-resolution images of relevant characters are presented and an identification key to males is provided.
Toward a revision of the bamboo corals: Part 1, species in the Muricellisidinae (Octocorallia: Isididae)
Authors: WATLING LES
Published: November 2020

The subfamily Muricellisidinae was erected by Kükenthal in 1915 and placed in the family Isididae in order to accommodate an unusual species collected in Sagami Bay, Japan. In 1931, Thomson and Dean added a second species collected in Indonesia during the Siboga Expedition. The holotypes of both species have been re-examined. Muricellisis echinata was found to be an anthothelid living on the axis of a keratoisid bamboo coral and M. cervicornis is a melithaeid. Both species are redescribed.
In Vivo Pharmacokinetics, Biodistribution and Toxicity of Antibody-Conjugated Gold Nanoparticles in Healthy Mice
Authors: Daems Noami , Verlinden Bart , Van Hoecke Karen , Cardinaels Thomas , Baatout Sarah , Michiels Carine , Lucas Stéphane , Aerts An
Published: November 2020

Cetuximab-conjugated gold nanoparticles are known to target cancer cells, but display toxicity towards normal kidney, liver and endothelial cells in vitro. In this study, we investigated their pharmacokinetics, biodistribution and toxicity after intravenous administration in
healthy mice. Our data showed that these nanoparticles were rapidly cleared from the blood and accumulated mainly in the liver and spleen with long-term retention. Acute liver injury, inflammatory activity and vascular damage were transient and negligible, as confirmed by the liver functionality
tests and serum marker analysis. There was no sign of altered liver, kidney, lung and spleen morphology up to 4 weeks post-injection. After 6 months, kidney casts and splenic apoptosis appeared to be more prevalent than in the controls. Furthermore, occasional immune cell infiltration was
observed in the lungs. Therefore, we recommend additional in vivo studies, in order to investigate the long-term toxicity and elimination of gold nanoparticles after multiple dosing in their preclinical validation as new targeted anti-cancer therapies.
Comprehensive 2D-Quantitative Structure-Activity Relationship Study on Monobactam Analogues Against Gram-Negative Bacteria
Authors: Zhang Dousheng , Zhang Xia , Li Zhiwen , Tang Sheng , Guo Zhihao , Hu Changqin , Zhang Jingpu , Song Danqing , Li Yinghong
Published: November 2020

Human health has been severely affected by infections resulting from multidrug-resistant (MDR) gram-negative bacteria (GNB). Monobactam antibiotics are known to be effective against such infections. This study aimed to construct a predictive two-dimensional quantitative structure-activity
relationship (2D-QSAR) model for the rational design of new monobactams based on the 65 known monobactams against Escherichia coli (Eco) and Klebsiella pneumonia (Kpn) strains using the kernel partial least squares regression (KPLS) algorithm. The total performance of
Eco and Kpn KPLS modes was shown as RMSE: 0.681/0.596, R2: 0.946/0.882, Q2: 0.922/0.877, and RMSU: 0.625/0.593. Thirty-four monobactams reported in our lab were chosen as external data to predict their activities against Eco and Kpn
using the newly established models, by which the R2 between the experimental and predicted values was 0.878 and 0.871, respectively. The models developed and verified in this study provide a powerful design strategy for novel monobactams that are effective against MDR gram-negative
bacterial infections.
Significant Toxic Effect of Carbon Nanofibers at the Early Stage of Embryogenesis
Authors: Abdo Ghada G. , Kheraldine Hadeel , Gupta Ishita , Rizeq Balsam , Elzatahry Ahmed , Al Moustafa Ala-Eddin , Khalil Ashraf
Published: November 2020

Implementation of carbon nanofibers (CNFs) in biomedical applications have successful outcomes, however, they are still considered as a potential hazard. We herein used avian embryos at 3 days and its chorioallantoic membrane (CAM) at 6 days of incubation to evaluate the impact of synthesized
CNFs on the early stage of embryogenesis and angiogenesis. Our data point out that 50 μg/embryo concentration of CNFs provoke adverse effects as 75% of CNFs-exposed embryos die within 1–5 days after exposure compared with their matched controls. Furthermore, CNFs significantly
inhibit angiogenesis of the CAM after 48-hours post-treatment. Additionally, RT-PCR analysis on seven key controller genes responsible for proliferation, survival, angiogenesis, and apoptosis showed that these genes are deregulated in brain, heart, and liver tissues of CNFs-exposed embryos
compared to their matched control. Our investigation suggests that CNFs could have a toxic effect on the early stages of embryogenesis as well as angiogenesis. Nevertheless, further investigations are required to evaluate the effects of CNFs and elucidate their mechanism on the early stage
of the normal development and human health.
Voters’ Perceptions of Gender Differences in Vote Buying: The Case of Tanzania
Authors: Yoon Mi Yung
Published: November 2020

I examine how voters perceive gender differences in vote buying, using survey and interview data collected in the Dar es Salaam region, Tanzania. I find that (1) an overwhelming majority of voters disapprove of vote buying, yet view it as remaining prevalent, and (2) they view men as more active vote buyers, mainly due to the gender gap in vote-buying opportunities. The perceived opportunity gap appears to come from a much larger representation of men in electoral competitions, the perceived gender gap in resources, and the absence of women in certain places and times, due to social and cultural norms constraining women’s behaviours, safety concerns, and/or household responsibilities.