bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of Post-Traumatic Growth in a Sample of United Kingdom Mental and Community Healthcare Workers during the COVID-19 Pandemic
Authors: Barnicot Kirsten , McCabe Rose , Bogosian Angeliki , Papadopoulos Renos , Crawford Mike , Aitken Peter , Christensen Tanja , Wilson Jonathan , Teague Bonnie , Rana Ravi , Willis Donna , Barclay Ryan , Chung Amy , Rohricht Frank
Published: February 2023

Experiences of adversity can generate positive psychological effects alongside negative impacts. Little research to date has evaluated predictors of post-traumatic growth in mental or community healthcare workers during the COVID-19 pandemic. Following a survey of 854 community and mental healthcare staff in the United Kingdom in July to September 2020, multiple linear regression was used to determine the association between hypothesised risk and protective factors (personal, organisational and environmental variables) and total scores on the Post-traumatic Growth Inventory–Short Version. Positive self-reflection activities, black and minority ethnic status, developing new healthcare knowledge and skills, connecting with friends and family, feeling supported by senior management, feeling supported by the UK people, and anxiety about the personal and work-related consequences of COVID-19 each significantly independently predicted greater post-traumatic growth. Working in a clinical role and in mental healthcare or community physical healthcare predicted lower post-traumatic growth. Our research supports the value of taking an organisational growth-focused approach to occupational health during times of adversity, by supporting staff to embrace opportunities for personal growth. Valuing staff’s cultural and religious identity and encouraging self-reflective activities, such as mindfulness and meditation, may help to promote post-traumatic growth.
Distress Signals: Age Differences in Psychological Distress before and during the COVID-19 Pandemic
Authors: Hale Sandra , Myerson Joel , Strube Michael J , Green Leonard , Lewandowski Amy B.
Published: February 2023

Psychological distress reached historically high levels in 2020, but why, and why were there pronounced age differences? We address these questions using a relatively novel, multipronged approach, part narrative review and part new data analyses. We first updated previous analyses of national surveys that showed distress was increasing in the US and Australia through 2017 and then re-analyzed data from the UK, comparing periods with and without lockdowns. We also analyzed the effects of age and personality on distress in the US during the pandemic. Results showed distress levels and age differences in distress were still increasing through 2019 in the US, UK, and Australia. The effects of lockdowns in 2020 revealed the roles of social deprivation and fear of infection. Finally, age-related differences in emotional stability accounted for the observed age differences in distress. These findings reveal the limitations of analyses comparing pre-pandemic and pandemic periods without accounting for ongoing trends. They also suggest that differences in personality traits such as emotional stability modulate responses to stressors. This could explain age and individual differences in both increases and decreases in distress in response to changes in the level of stressors such as those occurring prior to and during the COVID-19 pandemic.
New Digital Infrastructure’s Impact on Agricultural Eco-Efficiency Improvement: Influence Mechanism and Empirical Test—Evidence from China
Authors: Ren Jin , Chen Xinrui , Gao Tingting , Chen Hao , Shi Lefeng , Shi Ming
Published: February 2023

This paper attempts to explore the overall impact of its rural digitization process on agricultural carbon emissions and non-point source pollution in the context of China. By doing so, we analyze whether digitization has an impact on agricultural pollution reduction, analyze its conductive mechanism, and draw its policy implications. To this end, the paper innovatively incorporates new digital infrastructure and urbanization level into of the concept of agricultural eco-efficiency (AEE) and adopts the SBM-DEA model, entropy weighting method, and mixed regression to analyze, based on the sample data of the 30 provinces of China from 2011 to 2020. The results indicate that: (1) new digital infrastructure has a significant contribution to the improvement of AEE of China; (2) both information infrastructure and integration infrastructure have a significant positive effect on AEE, and the effect of information infrastructure is more effective, but there is an inverted “U”-shaped relationship between innovation infrastructure and AEE level; (3) the moderating effect mechanism suggests that the level of urbanization reinforces the contribution of new digital infrastructure to AEE; and (4) the heterogeneity test shows that the effect of new digital infrastructure on AEE is more significant in regions with well-developed traditional transportation facilities and in periods when the government pays more attention to agricultural ecological issues. The above results also provide rich insights for China and other similar developing countries on how to balance the agriculture digitization and AEE.
Acute Responses to High-Intensity Back Squats with Bilateral Blood Flow Restriction
Authors: Hornikel Bjoern , Saffold Keith S. , Esco Michael R. , Mota Jacob A. , Fedewa Michael V. , Wind Stefanie A. , Adams Tiffany L. , Winchester Lee J.
Published: February 2023

This study examined the acute effects of high-intensity resistance exercise with blood flow restriction (BFR) on performance and fatigue, metabolic stress, and markers of inflammation (interleukin-6 (IL-6)), muscle damage (myoglobin), angiogenesis (vascular endothelial growth factor (VEGF)). Thirteen resistance-trained participants (four female, 24.8 ± 4.7 years) performed four sets of barbell back-squats (75% 1RM) to failure under two conditions: blood flow restriction (BFR, bilateral 80% occlusion pressure) and control (CTRL). Completed repetitions and pre–post-exercise changes in maximal voluntary isometric contractions, countermovement jump, barbell mean propulsive velocity, and surface electromyography were recorded. Pre–post blood lactate (BLa) and venous blood samples for analysis of IL-6, myoglobin, and VEGF were collected. Ratings of perceived exertion (RPE) and pain were recorded for each set. Fewer repetitions were performed during BFR (25.5 ± 9.6 reps) compared to CTRL (43.4 ± 14.2 reps, p < 0.001), with greater repetitions performed during sets 1, 2, and 4 (p < 0.05) in CTRL. Although RPE between conditions was similar across all sets (p > 0.05), pain was greater in BFR across all sets (p < 0.05). Post-exercise fatigue was comparable between conditions. BLa was significantly greater in CTRL compared to BFR at two minutes (p = 0.001) but not four minutes post-exercise (p = 0.063). IL-6 was significantly elevated following BFR (p = 0.011). Comparable increases in myoglobin (p > 0.05) and no changes in VEGF were observed (p > 0.05). BFR increases the rate of muscular fatigue during high-intensity resistance exercise and acutely enhances IL-6 response, with significantly less total work performed, but increases pain perception, limiting implementation.
Study on the Spatial–Temporal Pattern and Driving Mechanism of Tourism Eco-Security in the Yellow River Basin
Authors: Zhao Junyuan , Wang Shengjie , Li Jiayue
Published: February 2023

Tourism eco-security evaluation is an effective tool for facilitating the coordinated and sustainable economic and environmental development of tourist destinations. Based on system theory, this study established a comprehensive evaluation index system for the DPSIR model, applying the entropy–TOPSIS method, spatial autocorrelation, spatial econometric model and geo-detector to investigate the spatial and temporal evolution and drivers of tourism eco-security of the Yellow River basin. The results showed that the tourism eco-security of the Yellow River basin steadily and significantly increased from 2003 to 2020, reaching a peak in 2019, while there was a low level of overall tourism eco-security and improvement possibility. The results show a spatial evolution pattern of expansion from provincial capital cities to nearby prefecture-level cities from the middle and lower reaches to the middle and upper reaches, with significant spatial clustering and spillover effects. Factors affecting the tourism eco-security of the Yellow River basin vary in and between regional basins. Because there are many influencing factors, the key factors were further identified by spatial effect decomposition. The results of this study have important theoretical and practical value in promoting the coordinated and sustainable development of the tourism economy and ecological environment in the Yellow River basin.
Meaningful Work, Happiness at Work, and Turnover Intentions
Authors: Charles-Leija Humberto , Castro Carlos G. , Toledo Mario , Ballesteros-Valdés Rosalinda
Published: February 2023

It has been documented that there is a positive relationship between a worker’s subjective well-being and productivity, and individuals who are happy in their work have a better attitude when performing activities: happier employees are more productive. Turnover intention, on the other hand, may arise from various factors rather than merely the need to increase a salary, as the traditional economic theory states. The fact that the work performed does not contribute to the worker’s life purpose, that there might be a bad relationship with colleagues, or else might play a role in the search for a new job. This study aims to show the relevance of meaningful work in happiness at work and turnover intention. Data from 937 professionals, in 2019, in Mexico were analyzed. Regression analyses were used to assess the impact of meaningful work on happiness at work and turnover intention. Results show that meaningful work, feeling appreciated by coworkers, and enjoyment of daily tasks significantly predict happiness at work. A logit model showed that having a job that contributes to people’s life purpose, feeling appreciated, and enjoyment of daily tasks reduces turnover intention. The main contribution of the study is to identify the importance of elements of purpose and meaning in the work context, contributing to economic theory. Limitations include the use of single items from a more extensive survey, which might diminish the validity and reliability of the constructs under scrutiny. Future directions point towards the need for more robust indicators of the variables of interest, but the findings emphasize the importance of research focused on the meaning workers attribute to their own work and the effects this attribution might have on their own wellbeing, organizational results, and productivity, including a return of investment (ROI) indicators.
Implications of Socio-Cultural Pressure for a Thin Body Image on Avoidance of Social Interaction and on Corrective, Compensatory or Compulsive Shopping Behaviour
Authors: Azevedo António , Azevedo Ângela Sá
Published: February 2023

This paper aims to discuss the implications of body talk and socio-cultural pressure for the internalisation of a thin body image in purchase decisions, shopping habits and other outcomes of body dissatisfaction, in particular the proneness to avoid human/social interaction in retail contexts and proneness to engage in corrective, compensatory or compulsive shopping behaviour. This paper conducted an online questionnaire that measured the following constructs: body mass index; Socio-cultural Attitudes Towards Appearance Scale-4 (SATAQ-4), Body Appreciation Scale (BAS-2), Acceptance of Cosmetic Surgery Scale (ACSS), Compulsive Buying Follow-up Scale (CBFS), proneness to avoid social interaction in retail contexts, and the intention to purchase a list of products and services as a compensation for body dissatisfaction. A structural equations model supported the hypotheses proposing the influence of BAS-2 and SATAQ-4 (the internalisation of thin/athletic body and the social comparison induced by family, peers and media) upon the outcomes of social-interaction avoidance, ACSS and CBFS. Nevertheless, BAS-2 only influences social-interaction avoidance. This paper provides several recommendations to brand managers highlighting the social responsibility role of brand advertising in enhancing positive body appreciation, mitigating the psychological damage caused by socio-cultural pressure and preventing the stigmatisation bias against obese people.
Metastatic Melanoma: Liquid Biopsy as a New Precision Medicine Approach
Authors: Ricciardi Elena , Giordani Elena , Ziccheddu Giovanna , Falcone Italia , Giacomini Patrizio , Fanciulli Maurizio , Russillo Michelangelo , Cerro Marianna , Ciliberto Gennaro , Morrone Aldo , Guerrisi Antonino , Valenti Fabio
Published: February 2023

Precision medicine has driven a major change in the treatment of many forms of cancer. The discovery that each patient is different and each tumor mass has its own characteristics has shifted the focus of basic and clinical research to the singular individual. Liquid biopsy (LB), in this sense, presents new scenarios in personalized medicine through the study of molecules, factors, and tumor biomarkers in blood such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), exosomes and circulating tumor microRNAs (ct-miRNAs). Moreover, its easy application and complete absence of contraindications for the patient make this method applicable in a great many fields. Melanoma, given its highly heterogeneous characteristics, is a cancer form that could significantly benefit from the information linked to liquid biopsy, especially in the treatment management. In this review, we will focus our attention on the latest applications of liquid biopsy in metastatic melanoma and possible developments in the clinical setting.
Counteracting the Common Shwachman–Diamond Syndrome-Causing SBDS c.258+2T>C Mutation by RNA Therapeutics and Base/Prime Editing
Authors: Peretto Laura , Tonetto Elena , Maestri Iva , Bezzerri Valentino , Valli Roberto , Cipolli Marco , Pinotti Mirko , Balestra Dario
Published: February 2023

Shwachman–Diamond syndrome (SDS) represents one of the most common inherited bone marrow failure syndromes and is mainly caused by SBDS gene mutations. Only supportive treatments are available, with hematopoietic cell transplantation required when marrow failure occurs. Among all causative mutations, the SBDS c.258+2T>C variant at the 5′ splice site (ss) of exon 2 is one of the most frequent. Here, we investigated the molecular mechanisms underlying aberrant SBDS splicing and showed that SBDS exon 2 is dense in splicing regulatory elements and cryptic splice sites, complicating proper 5′ss selection. Studies ex vivo and in vitro demonstrated that the mutation alters splicing, but it is also compatible with tiny amounts of correct transcripts, which would explain the survival of SDS patients. Moreover, for the first time for SDS, we explored a panel of correction approaches at the RNA and DNA levels and provided experimental evidence that the mutation effect can be partially counteracted by engineered U1snRNA, trans-splicing, and base/prime editors, ultimately leading to correctly spliced transcripts (from barely detectable to 2.5–5.5%). Among them, we propose DNA editors that, by stably reverting the mutation and potentially conferring positive selection to bone-marrow cells, could lead to the development of an innovative SDS therapy.
Novel Molecules in Diabetes Mellitus, Dyslipidemia and Cardiovascular Disease
Authors: Vesa Cosmin Mihai , Bungau Simona Gabriela
Published: February 2023

The purpose of this Special Issue is to present the impact in clinical practice as well as in medical research of novel molecules that have been introduced in the treatment of diabetes mellitus, dyslipidaemia, and cardiovascular disease [...]
Isolation and Characterization of the First Zobellviridae Family Bacteriophage Infecting Klebsiella pneumoniae
Authors: Gorodnichev Roman B. , Kornienko Maria A. , Malakhova Maja V. , Bespiatykh Dmitry A. , Manuvera Valentin A. , Selezneva Oksana V. , Veselovsky Vladimir A. , Bagrov Dmitry V. , Zaychikova Marina V. , Osnach Veronika A. , Shabalina Anna V. , Goloshchapov Oleg V. , Bespyatykh Julia A. , Dolgova Anna S. , Shitikov Egor A.
Published: February 2023

In order to address the upcoming crisis in the treatment of Klebsiella pneumoniae infections, caused by an increasing proportion of resistant isolates, new approaches to antimicrobial therapy must be developed. One approach would be to use (bacterio)phages and/or phage derivatives for therapy. In this study, we present a description of the first K. pneumoniae phage from the Zobellviridae family. The vB_KpnP_Klyazma podovirus, which forms translucent halos around the plaques, was isolated from river water. The phage genome is composed of 82 open reading frames, which are divided into two clusters located on opposite strands. Phylogenetic analysis revealed that the phage belongs to the Zobellviridae family, although its identity with the closest member of this family was not higher than 5%. The bacteriophage demonstrated lytic activity against all (n = 11) K. pneumoniae strains with the KL20 capsule type, but only the host strain was lysed effectively. The receptor-binding protein of the phage was identified as a polysaccharide depolymerase with a pectate lyase domain. The recombinant depolymerase protein showed concentration-dependent activity against all strains with the KL20 capsule type. The ability of a recombinant depolymerase to cleave bacterial capsular polysaccharides regardless of a phage’s ability to successfully infect a particular strain holds promise for the possibility of using depolymerases in antimicrobial therapy, even though they only make bacteria sensitive to environmental factors, rather than killing them directly.
New Approaches in Early-Stage NSCL Management: Potential Use of PARP Inhibitors and Immunotherapy Combination
Authors: Fernandes Marta Pina , Oliveira Cristina , Sousa Hugo , Oliveira Júlio
Published: February 2023

Lung cancer is the second most common cancer in the world, being the first cause of cancer-related mortality. Surgery remains the only potentially curative treatment for Non-Small Cell Lung Cancer (NSCLC), but the recurrence risk remains high (30–55%) and Overall Survival (OS) is still lower than desirable (63% at 5 years), even with adjuvant treatment. Neoadjuvant treatment can be helpful and new therapies and pharmacologic associations are being studied. Immune Checkpoint Inhibitors (ICI) and PARP inhibitors (PARPi) are two pharmacological classes already in use to treat several cancers. Some pre-clinical studies have shown that its association can be synergic and this is being studied in different settings. Here, we review the PARPi and ICI strategies in cancer management and the information will be used to develop a clinical trial to evaluate the potential of PARPi association with ICI in early-stage neoadjuvant setting NSCLC.
Homogeneity in Surgical Series: Image Reporting to Improve Evidence
Authors: Regazzoni Pietro , Lambert Simon , Jupiter Jesse B. , Südkamp Norbert , Liu Wen-Chih , Fernández Dell’Oca Alberto A.
Published: February 2023

Good clinical practice guidelines are based on randomized controlled trials or clinical series; however, technical performance bias among surgical trials is under-assessed. The heterogeneity of technical performance within different treatment groups diminishes the level of evidence. Surgeon variability with different levels of experience—technical performance levels even after certification—influences surgical outcomes, especially in complex procedures. Technical performance quality correlates with the outcomes and costs and should be measured by image or video-photographic documentation of the surgeon’s view field during the procedures. Such consecutive, completely documented, unedited observational data—in the form of intra-operative images and a complete set of eventual radiological images—improve the surgical series’ homogeneity. Thereby, they might reflect reality and contribute towards making necessary changes for evidence-based surgery.
Are Predictors for Overall Mortality in COPD Patients Robust over Time?
Authors: Sievi Noriane , Sepin Jerome , Roeder Maurice , Brack Thomas , Brutsche Martin , Frey Martin , Irani Sarosh , Leuppi Jörg , Thurnheer Robert , Clarenbach Christian , Kohler Malcolm
Published: February 2023

(1) Background: Mortality is a major outcome in research on chronic obstructive pulmonary disease (COPD) with various predictors described. However, the dynamic courses of important predictors over time are disregarded. This study evaluates if longitudinal assessment of predictors provides additional information on the mortality risk in COPD when compared with a cross-sectional analysis.; (2) In a longitudinal, prospective, non-interventional cohort study including mild to very severe COPD patients, mortality and its various possible predictors were annually assessed up to seven years.; (3) Results: 297 patients were analysed. Mean (SD) age was 62.5 (7.6) years and 66% males. Mean (SD) FEV1 was 48.8 (21.4)%. A total of 105 events (35.4%) happened with a median (95% CI) survival time of 8.2 (7.2/NA) years. No evidence for a difference between the raw variable and the variable history on the predictive value for all tested variables over each visit was found. There was no evidence for changing effect estimates (coefficients) across the study visits due to the longitudinal assessment; (4) Conclusions: We found no evidence that predictors of mortality in COPD are time dependent. This implies that cross-sectional measured predictors show robust effect estimates over time and multiple assessments seem not to change the predictive value of the measure.
The Female Pelvis Is Associated with a Lateralized Ischium and a Reduced Ischiofemoral Space
Authors: Ahmad Sufian S. , Konrads Christian , Niemann Marcel , Stöckle Ulrich , Windhagen Henning , Giebel Gregor M.
Published: February 2023

Background: Pelvi-femoral conflicts are increasingly recognized for their explanatory role in the pathology of extra-articular hip impingement. Ischiofemoral impingement (IFI) is a type of impingement between the femur and the ischium that causes high femoral antetorsion and valgus femoral neck orientation. It is unknown whether obstetric adaptation of the female pelvis renders the female hip at a higher risk of sustaining IFI. The aim of this study was to determine the influence of the pelvic morphology on the ischiofemoral space (IFS). Methods: Plain radiographs of healthy individuals with no symptomatic hip disease were obtained in a functional standing position in a standardized manner and utilized for measurement of the interischial and ischiofemoral widths, subpubic angle, and centrum collum diaphyseal (CCD) angle. Linear regression was performed to determine the influence of morphometric measures on the ischiofemoral space. Results: Sixty-five radiographs (34 females and 31 males) were included. The cohort was stratified according to gender. Significant gender-related differences were noted regarding the ischiofemoral distance (31% increase in males, p < 0.001), pubic-arc angle (30% increased in females, p < 0.001), and the interischial space (7% increase in females, p < 0.001). CCD did not significantly differ between genders (p = 0.2). Factors influencing the IFS include the pubic-arc angle (β = −0.01 (CI −0.02–−0.00), p = 0.003), interischial distance (β = −0.11 (CI −0.23–−0.00), p = 0.049) and CCD (β = −0.06 (CI −0.09–−0.04), p < 0.001). Conclusions: Obstetric adaptation is associated with an increased subpubic angle that shifts the ischia laterally and away from the symphysis. The resultant reduction in the ischiofemoral space renders the female pelvis at a higher risk for a pelvi-femoral conflict, or more precisely, an ischiofemoral conflict, due to the reduced ischiofemoral space of the hip. The CCD angle of the femur was shown not to be gender specific. However, the CCD angle demonstrates an influence on the ischiofemoral space, rendering the proximal femur a target for corresponding osteotomies.
Pacemaker Implantation following Heart Transplantation: Analysis of a Nation-Wide Database
Authors: Doulamis Ilias P. , Wu BoChang , Akbar Armaan F. , Xanthopoulos Andreas , Androulakis Emmanuel , Briasoulis Alexandros
Published: February 2023

Background: The 2018 United-Network-for-Organ-Sharing (UNOS) allocation-system changes resulted in greater recognition of mechanical circulatory support (MCS), leading to more heart transplantations (HTx) in patients with MCS. We aimed to investigate the effect of the new UNOS allocation system on the need for a permanent pacemaker and associated complications following HTx. Methods: The UNOS Registry was questioned, to identify patients that received HTx in the US between 2000 and 2021. The primary objectives were to identify risk factors for the need for a pacemaker implantation following HTx. Results: 49,529 HTx patients were identified, 1421 (2.9%) requiring a pacemaker post-HTx. Patients who required a pacemaker were older (53.9 ± 11.5 vs. 52.6 ± 12.8 years, p < 0.001), more frequently white (73% vs. 67%; p < 0.001) and less frequently black (18% vs. 20%; p < 0.001). In the pacemaker group, UNOS status 1A (46% vs. 41%; p < 0.001) and 1B (31% vs. 27%; p < 0.001) were more prevalent, and donor age was higher (34.4 ± 12.4 vs. 31.8 ± 11.5 years; p < 0.001). One-year survival was no different between the groups (HR: 1.08; 95% CI: 0.85, 1.37; p = 0.515). An era effect was observed (per year: OR: 0.97; 95% CI: 0.96, 0.98; p = 0.003), while ECMO pre-transplant was associated with lower risk of a pacemaker (OR: 0.41; 95% CI: 0.19, 0.86; p < 0.001). Conclusions: While associated with various patient and transplant characteristics, pacemaker implantation does not seem to impact one-year survival after HTx. The need for pacemaker implantation was lower in the more recent era and in patients who required ECMO pre-transplant, a finding explained by recent advances in perioperative care.
Safety and Efficacy of Dexmedetomidine for Bronchoscopy: A Systematic Review and Meta-Analysis
Authors: Guo Qianqian , An Qi , Zhao Lin , Wu Meng , Wang Ye , Guo Zhenggang
Published: February 2023

(1) Background: Anesthetic sedatives are widely used for bronchoscopy, and controversy surrounds the safety and efficacy of dexmedetomidine compared to other sedatives. The aim of this study is to evaluate the safety and efficacy of dexmedetomidine in bronchoscopy through a systematic review. (2) Methods: PubMed, Embase, Google Scholar, and Cochrane Library electronic databases were searched for a randomized controlled study of dexmedetomidine (Group D) or other sedative drugs (Group C) for bronchoscopy. Data extraction, quality assessment, and risk of bias analysis were performed in accordance with the preferred reporting items for systematic review and meta-analysis requirements. Meta-analysis was performed using RevMan 5.2. (3) Results: Nine studies were included, with a total of 765 cases. Compared to Group C, the incidence of hypoxemia (OR = 0.40, 95% CI (0.25, 0.64) p = 0.0001, I2 = 8%) and tachycardia (OR = 0.44, 95% CI (0.26,0.74), p = 0.002, I2 = 14%) were lower, but bradycardia (OR = 3.71, 95% CI (1.84, 7.47), p = 0.0002, I2 = 0%) was higher in Group D; no significant difference was observed in other outcome indicators. (4) Conclusions: Dexmedetomidine reduces the incidence of hypoxemia and tachycardia during bronchoscopy but is more likely to provoke bradycardia.
Prognostic Value of Peritoneal Cytology in Stage I Serous and Clear Cell Carcinoma of the Endometrium
Authors: Yang Jie , Yang Jiaxin , Cao Dongyan , Wu Ming , Xiang Yang
Published: February 2023

(1) Background: To investigate the relation between malignant peritoneal cytology and survival outcomes in patients who underwent primary staging surgery for stage I uterine serous (USC) or clear cell carcinoma (UCCC). (2) Methods: In this retrospective analysis, patients with stage I USC or UCCC who underwent staging surgery between 2010 and 2020 at the Peking Union Medical College Hospital were identified and reviewed. (3) Results: A total of 101 patients were included, and 11 patients had malignant cytology (10.9%). The median follow-up time was 44 months (range 6–120) with a total of 11 (10.9%) recurrences. Patients with malignant cytology had a higher likelihood of peritoneal recurrence and a shorter time to relapse (13 vs. 38 months, p = 0.022), as compared to patients with negative cytology. In univariate analysis, malignant cytology and serous histology had worse progression-free survival (PFS) and overall survival (OS) (all, p < 0.05). In sensitive analysis, the detrimental effects of malignant cytology on survival were more prominent in patients over 60 years old, those with serous histology, stage IB disease, and those who received hysteroscopy as a diagnostic test. (4) Conclusions: Stage I USC or UCCC patients with malignant peritoneal cytology had a higher recurrence and inferior survival.
Progression of Selected Parameters of the Clinical Profile of Patients with Periodontitis Using Kohonen’s Self-Organizing Maps
Authors: Ossowska Agata , Kusiak Aida , Świetlik Dariusz
Published: February 2023

(1) Background: Periodontitis is an inflammatory condition that affects the tissues surrounding the tooth and causes clinical attachment loss, which is the loss of periodontal attachment (CAL). Periodontitis can advance in various ways, with some patients experiencing severe periodontitis in a short period of time while others may experience mild periodontitis for the rest of their lives. In this study, we have used an alternative methodology to conventional statistics, self-organizing maps (SOM), to group the clinical profiles of patients with periodontitis. (2) Methods: To predict the periodontitis progression and to choose the best treatment plan, we can use artificial intelligence, more precisely Kohonen’s self-organizing maps (SOM). In this study, 110 patients, both genders, between the ages of 30 and 60, were included in this retrospective analysis. (3) Results: To discover the pattern of patients according to the periodontitis grade and stage, we grouped the neurons together to form three clusters: Group 1 was made up of neurons 12 and 16 that represented a percentage of slow progression of almost 75%; Group 2 was made up of neurons 3, 4, 6, 7, 11, and 14 in which the percentage of moderate progression was almost 65%; and Group 3 was made up of neurons 1, 2, 5, 8, 9, 10, 13, and 15 that represented a percentage of rapid progression of almost 60%. There were statistically significant differences in the approximate plaque index (API), and bleeding on probing (BoP) versus groups (p < 0.0001). The post-hoc tests showed that API, BoP, pocket depth (PD), and CAL values were significantly lower in Group 1 relative to Group 2 (p < 0.05) and Group 3 (p < 0.05). A detailed statistical analysis showed that the PD value was significantly lower in Group 1 relative to Group 2 (p = 0.0001). Furthermore, the PD was significantly higher in Group 3 relative to Group 2 (p = 0.0068). There was a statistically significant CAL difference between Group 1 relative to Group 2 (p = 0.0370). (4) Conclusions: Self-organizing maps, in contrast to conventional statistics, allow us to view the issue of periodontitis advancement by illuminating how the variables are organized in one or the other of the various suppositions.
Neuroprotective Potential of Biflavone Ginkgetin: A Review
Authors: Tatlı Çankaya İ. İrem , Devkota Hari Prasad , Zengin Gokhan , Šamec Dunja
Published: February 2023

Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results. Ginkgetin is the first known biflavonoid, a flavonoid dimer isolated from ginkgo (Ginkgo biloba L.). Later, its occurrence was discovered in more than 20 different plant species, most of which are known for their use in traditional medicine. Herein we have summarized the data on the neuroprotective potential of ginkgetin. There is evidence of protection against neuronal damage caused by ischemic strokes, neurotumors, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Beneficial effects in ischemic strokes have been demonstrated in animal studies in which injection of ginkgetin before or after onset of the stoke showed protection from neuronal damage. AD protection has been the most studied to date. Possible mechanisms include inhibition of reactive oxygen species, inhibition of β-secretase, inhibition of Aβ fibril formation, amelioration of inflammation, and antimicrobial activity. Ginkgetin has also shown positive effects on the relief of PD symptoms in animal studies. Most of the available data are from in vitro or in vivo animal studies, where ginkgetin showed promising results, and further clinical studies should be conducted.
Effect of APS Spraying Parameters on the Microstructure Formation of Fe3Al Intermetallics Coatings Using Mechanochemically Synthesized Nanocrystalline Fe-Al Powders
Authors: Senderowski Cezary , Vigilianska Nataliia , Burlachenko Oleksii , Grishchenko Oleksandr , Murashov Anatolii , Stepanyuk Sergiy
Published: February 2023

The present paper presents a study of the behaviour of Fe3Al intermetallic powders particles based on 86Fe-14Al, 86Fe-14(Fe5Mg), and 60.8Fe-39.2(Ti37.5Al) compositions obtained by mechanochemical synthesis at successive stages of the plasma spraying process: during transfer in the volume of the gas stream and deformation at the moment of impact on the substrate. The effect of the change in current on the size of powder particles during their transfer through the high-temperature stream and the degree of particle deformation upon impact with the substrate was determined. It was found that during transfer through the plasma jet, there was an increase in the average size of sputtering products by two–three times compared to the initial effects of mechanochemical synthesis due to the coagulation of some particles. In this case, an increase in current from 400 to 500 A led to a growth in average particle size by 14–47% due to the partial evaporation of fine particles with an increase in their heating degree. An increase in current also led to a 5–10% growth in particle deformation degree upon impact on the substrate due to the rising temperature and velocity of the plasma jet. Based on the research, the parameters of plasma spraying of mechanically synthesized Fe3Al intermetallic-based powders were determined, at which dense coatings with a thin-lamellar structure were formed.
Bredigite-CNTs Reinforced Mg-Zn Bio-Composites to Enhance the Mechanical and Biological Properties for Biomedical Applications
Authors: Zhang Hongwei , Saberi Abbas , Heydari Zahra , Baltatu Madalina Simona
Published: February 2023

Magnesium (Mg) and its compounds have been investigated as biodegradable metals for bone implants. However, high corrosion rates and low bioactivity that cause loss of mechanical properties are factors that have limited their biomedical applications. The purpose of this work is to remedy the weaknesses of the Mg–Zn (MZ) alloy matrix. For this purpose, we have synthesized Mg-based composites with different concentrations of bredigite (Br; Ca7MgSi4O16)–carbon nanotubes (CNTs) using mechanical alloying and semi-powder metallurgy processes with spark plasma sintering. Then, we studied the effect of the simultaneous addition of Br-CNTs on in vitro degradation, as well as its effect on the composites’ mechanical and antibacterial properties. Increases of 57% and 72% respectively were observed in the microhardness and compressive strength of the MZ/Br-CNTs composite in comparison to the MZ alloy. In addition, the rate of degradation of Mg-based composites in simulated body fluids (SBF) was almost 2 times lower. An assessment of antibacterial behavior disclosed that the simultaneous adding of Br-CNTs to Mg can meaningfully prevent the growth and invasion of E. coli and S. aureus. These research findings demonstrate the potential application of MZ/Br-CNTs composites to implants and the treatment of bone infections.
Experiment Study on the Influence of Density and Confining Pressure on Triaxial Shear Properties of Calcareous Sand
Authors: Zhang Hui , Ren Huiqi , Mu Chaomin , Wu Xiangyun , Huang Kui , Wang Fei
Published: February 2023

Calcareous sand is one of the main building materials in the construction of islands and reefs, and its shear property is very important for predicting their strength and deformation. However, the correlation research on the shear properties of calcareous sand is limited. In this paper, a series of the triaxial consolidation drainage shear tests of calcareous sand with relative densities (Dr) of 70% and 90% under confining pressures of 100, 200, 400 and 800 kPa were carried out by a triaxial testing apparatus, and the effects of relative density and confining pressure on the deformation and strength characteristics of calcareous sand were analyzed. The results show that the stress–strain curves of calcareous sand show a strain softening characteristic, and both peak deviatoric stress and failure strain increase with confining pressure, but the increase in failure strain is restrained when the confining pressure is larger than 400 kPa. The initial shear modulus of calcareous sand is positively correlated with confining pressure. Additionally, the molar circular envelope of calcareous sand is linear in the range of 100~400 kPa, but it deviates from linear when confining pressure exceeds 400 kPa. The critical state line (CSL) of calcareous sand is nonlinear, with almost the same exponent for calcareous sand with different relative densities. The research results have important reference value for the foundation construction of islands and reefs.
Solution-Route Inkjet Fabrication of CeO2 Thin Films with Tunable Microstructure
Authors: Singh Veena , Belova Lyubov
Published: February 2023

We report the fabrication and characterization of solution-route CeO2 thin films with a tunable porosity and microstructure. Films were deposited by means of inkjet printing technique using 0.2 M, 0.4 M and 0.6 M concentration inks prepared from Ce(NO3)3·6H2O precursor. Printing was performed at two different temperatures of 60 °C and 300 °C to study the variation in structure. Printing parameters were adjusted for the consecutive deposition of layers, resulting in ≈140 nm and ≈185 nm thick single layers for 60 °C and 300 °C printing temperatures, respectively. We compared the microstructure of printed films for different concentrations, printing temperatures, solvents and substrates. The formation of the cubic fluorite structure of the printed films was confirmed via XRD characterization. We suggest this technique as an advanced method for high-quality film fabrication with a controlled microstructure and with a minimal waste of materials. Through adjusting printing parameters, both dense and porous films can be produced for use in different applications.
A 3D Numerical Study of the Surface Dielectric Barrier Discharge Initial Phase
Authors: Mikeš Jan , Soukup Ivan , Pekárek Stanislav
Published: February 2023

This study presents the results of the numerical modeling of surface dielectric barrier discharge in planar configuration with the strips active electrode. A positive half-period of the sinusoidal driving voltage and the two-species case is assumed in this study. Currently, many numerical models of surface dielectric barrier discharge deal with different electrode geometries, longer timescales, or discharge energizations. However, the main innovation presented in this study is developing a three-dimensional numerical model for the initial phase of the discharge phenomenon and a deeper focus on the numerical theory behind it. Based on the fluid model, this study presents a detailed mathematical and numerical formulation of the problem, stable numerical reconstruction of ion and electron velocity fields and an explanation of the need for linear approximation of ionization rate. Finally, it computes the potential and electric field distributions, electron and ion densities, and their velocities. The obtained results of a numerical simulation showing trajectories and velocities of electrons and ions reflect the active region of the discharge. A numerical simulation demonstrates the method in a three-dimensional domain inspired by a real-life experiment. The model can be used to optimize the electrode geometry of the discharge.
Bioactivity Profiling and Untargeted Metabolomics of Microbiota Associated with Mesopelagic Jellyfish Periphylla Periphylla
Authors: Oppong-Danquah Ernest , Miranda Martina , Blümel Martina , Tasdemir Deniz
Published: February 2023

The marine mesopelagic zone extends from water depths of 200 m to 1000 m and is home to a vast number and diversity of species. It is one of the least understood regions of the marine environment with untapped resources of pharmaceutical relevance. The mesopelagic jellyfish Periphylla periphylla is a well-known and widely distributed species in the mesopelagic zone; however, the diversity or the pharmaceutical potential of its cultivable microbiota has not been explored. In this study, we isolated microorganisms associated with the inner and outer umbrella of P. periphylla collected in Irminger Sea by a culture-dependent approach, and profiled their chemical composition and biological activities. Sixteen mostly gram-negative bacterial isolates were selected and subjected to an OSMAC cultivation regime approach using liquid and solid marine broth (MB) and glucose–yeast–malt (GYM) media. Their ethyl acetate (EtOAc) extracts were assessed for cytotoxicity and antimicrobial activity against fish and human pathogens. All, except one extract, displayed diverse levels of antimicrobial activities. Based on low IC50 values, four most bioactive gram-negative strains; Polaribacter sp. SU124, Shewanella sp. SU126, Psychrobacter sp. SU143 and Psychrobacter sp. SU137, were prioritized for an in-depth comparative and untargeted metabolomics analysis using feature-based molecular networking. Various chemical classes such as diketopiperazines, polyhydroxybutyrates (PHBs), bile acids and other lipids were putatively annotated, highlighting the biotechnological potential in P. periphylla-associated microbiota as well as gram-negative bacteria. This is the first study providing an insight into the cultivable bacterial community associated with the mesopelagic jellyfish P. periphylla and, indeed, the first to mine the metabolome and antimicrobial activities of these microorganisms.
Knowledge Mapping and Research Hotspots of Comorbidities in Psoriasis: A Bibliometric Analysis from 2004 to 2022
Authors: Huang Shan , Bai Yanping
Published: February 2023

Background and Objectives: Psoriasis is a chronic inflammatory disease whose impact on health is not only limited to the skin, but is also associated with multiple comorbidities. Early screening for comorbidities along with appropriate treatment plans can provide a positive prognosis for patients. This study aimed to summarize the knowledge structure in the field of psoriasis comorbidities and further explore its research hotspots and trends through bibliometrics. Materials and Methods: A search was conducted in the core collection of the Web of Science for literature on comorbidities of psoriasis from 2004 to 2022. VOSviewer and CiteSpace software were used for collaborative network analysis, co-citation analysis of references, and keyword co-occurrence analysis on these publications. Results: A total of 1803 papers written by 6741 authors from 81 countries was included. The publications have shown a progressive increase since 2004. The United States and Europe were at the forefront of this field. The most prolific institution was the University of California, and the most productive author was A. Armstrong. Research has focused on “psoriatic arthritis”, “metabolic syndrome”, “cardiovascular disease”, “psychosomatic disease”, “inflammatory bowel disease”, “prevalence”, “quality of life”, and “risk factor” in the past 18 years. Keywords such as “biologics” and “systemic inflammation”, have been widely used recently, suggesting current research hotspots and trends. Conclusions: Over the past 18 years, tremendous progress has been made in research on psoriasis comorbidity. However, collaborations among countries, institutions, and investigators are inadequate, and the study of the mechanisms of interaction between psoriasis and comorbidities and management of comorbidities is insufficient. The treatment of comorbidities with biologic agents, screening of comorbidities, and multidisciplinary co-management are predicted to be the focus of future research.
Preparation of a CAB−GO/PES Mixed Matrix Ultrafiltration Membrane and Its Antifouling Performance
Authors: Wu Haiyan , Wang Ling , Xu Wentao , Xu Zehai , Zhang Guoliang
Published: February 2023

Serious membrane fouling has limited the development of ultrafiltration membrane technology for water purification. Synthesis of an ultrafiltration membrane with prominent anti-fouling ability is of vital importance. In this study, CAB−GO composite nanosheets were prepared by grafting graphene oxide (GO) with a zwitterionic material cocamidopropyl betaine (CAB) with strong antifouling properties. Anti-fouling CAB−GO/PES mixed matrix ultrafiltration membrane (CGM) was prepared by the phase inversion method with polyethersulfone (PES). Due to its electrostatic interaction, the interlayer distance between CAB−GO nanosheets was increased, and the dispersibility of GO was improved to large extent, thereby effectively avoiding the phenomenon of GO agglomeration in organic solvents. Based on the improvement of the surface porosity and surface hydrophilicity of the CAB−GO/PES mixed matrix membrane, the pure water flux of CGM−1.0 can reach 461 L/(m2·h), which was 2.5 times higher than that of the original PES membrane, and the rejection rates toward BSA and HA were above 96%. Moreover, when the content of CAB−GO was 0.1 wt%, the prepared CAB−GO/PES membrane exhibited very high BSA (99.1%) and HA (98.1%) rejection during long-term operation, indicating excellent anti-fouling ability.
Experimental Study on Desulfurization and Removal of Alkali Behavior of BF Slag System in Low-Slag Ironmaking
Authors: Xu Lei , Qing Gele , Cheng Xiangfeng , Xu Meng , Zhao Baojun , Liao Jinfa
Published: February 2023

The increased utilization of pellets in blast furnaces is one of the directions for low-carbon ironmaking. As a result, the low slag rate may affect the desulfurization of the hot metal and the removal of alkali in the blast furnace. Effective desulfurization and the removal of alkali in the low slag ironmaking process have become the focus of the steel industry. In this paper, the effects of slag quantity, temperature, reaction time and slag composition on the desulfurization and removal of alkali were studied using the slag-metal reaction method. It was found that the slag quantity had the same influence trend on the desulfurization and the removal of alkali. The greater the slag quantity, the more effective the desulfurization and the removal of alkali. The slag composition, temperature and reaction time had the opposite effect on the desulfurization and the removal of alkali. High temperature, long reaction time, high MgO concentration, high CaO/SiO2 ratio and low Al2O3 concentration increased the desulfurization of hot metal but reduced the removal rate of alkali from the blast furnace. Applications of the experimental results on high-proportion pellet blast furnace operation are discussed.