bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of anesthesia on cancer progression and anti-tumor immunity. A review
Authors: Grigorios lyronis , Eleni Efremidou , Maria-Eleni Zachou , Antigoni Kaprana , Michael Koukourakis , Pelagia Chloropoulou
Published: April 2024

Introduction: Breast cancer is one of the most common malignancies, treated with primary surgery, or surgery after neoadjuvant chemotherapy. Many studies indicate that the peri-operative period is critical as interference with the immune system may affect prognosis. Whether certain anesthetic agents can affect the immune response and cancer progression is still unresolved. Evidence acquisition: In the current study, we review the existing clinical and experimental studies, in an attempt to extract useful information for clinical application in the anesthesia practice for patients treated with surgery for breast cancer. A bibliographic search in PubMed and ScienceDirect related to the effects of anesthesia on cancer progression and anti-tumor immunity, published from January 2000 till today was performed. Evidence synthesis: All included studies were gathered in a list and they were analysed. A total of 34 studies were found relevant to the subject in PubMed and ScienceDirect. Conclusion: The overall experience suggests that the peri-operative management of cancer patients should focus on the reduction of surgical stress, the minimization of the use of opioids, and the adoption of regional anesthetics. This could have an impact on anti-tumour immunity and the outcome of cancer patients.
Atributos morfológicos, físicos y rendimiento en partidos en jugadores jóvenes de balonmano
Authors: Resina de Oliveira Campos Renato , Volossovitch Anna , Pereira Ferreira António Paulo
Published: April 2024

The aim of this study was threefold: 1) to compare the morphological and physical attributes of the young players divided into two different maturational groups; 2) to  analyze the association between the morphological and physical attributes and the game performance of young players, taking into account their maturational state; and finally 3) to verify if the subjective coach’s opinion about the individual performance and players’ potential is influenced by players’ game performance and the morphological and physical attributes. The sample consisted of 40 young handball players divided into pre- and post-peak height velocity. The morphological and physical attributes of players from each group, as well as the association of these attributes with the competitive performance were analyzed and compared. The results confirmed the significant differences between both groups in all morphological characteristics and the results of physical assessment. It was found that the morphological and physical attributes associated with better competitive performance differ according to the maturation state of the players. The study confirmed the importance of maturational assessment in the interpretation of physical tests results, morphological assessments and competitive performance of handball players in the ages near the pubertal growth spurt.
Monitorización de la carga de entrenamiento por posición y tareas en baloncesto profesional masculino
Authors: Ponce Bordón José Carlos , Ramírez Bravo Iván , López Gajardo Miguel Ángel , Díaz García Jesús
Published: April 2024

The aim of this study was to analyze the training load of the different tasks of a professional basketball team, based on the tasks and player positions. A total of 10 professional basketball players participated (Mage = 23.70; SD = 2.26) who carried out three different training tasks for four weeks: situation in the middle court (MC); situation in the middle court followed by a counterattack in the opposite court (FB); half court situation followed by two full court counterattack situations (CB). GPS Polar Team Pro© was used to monitoring the physical load. Internal physical load and external physical load variables were measured. One-way ANOVA was performed to explore the main differences between the different types of tasks and player positions on each of the dependent variables. The results show that FB tasks involve a higher internal load, while CB tasks involve a greater external load. Regarding the type of players, the exteriors reached higher values in the different variables analyzed. Therefore, it has been found that different training tasks imply different physical demands. Specifically, using training tasks that reproduce the dynamics of competition imply an increase in conditional load.
El valor de la evaluación para el aprendizaje en la enseñanza de la educación física
Authors: Moura André , Silva Ana , Graça Amândio , Batista Paula
Published: April 2024

This study report a pedagogical experience focused on the use of assessment for learning principles in physical education during the school placement. The propose was to capture the value and meaning ascribed by preservice teachers and students involved on this study. Participated, four preservice teachers and 94 students on secondary education at two schools situated on the region of Porto. Preservice teachers’ perceptions were collected through individual interviews, log diary and school placement report. Students’ perceptions were collected through teaching artefacts (dossier, self and peer assessment forms) and focus group interviews. Data were triangulated and subject to a thematic analysis (Bardin, 2008), resulting in three main themes: instructional alignment, student-centred teaching, authentic learning. Findings show that: teaching-learning process was clear and shared among students and preservice teachers; preservice teachers acted as facilitators of the process while students acted as the main responsible; students learned on a personal and social level; and preservice teachers changed their teaching.
Lógica estadística de la interacción de marca en los playoffs de la NBA (2014-2019): Factores espaciales y temporales
Authors: Martínez-Santos Raúl , Oiarbide Asier , Enjuanes Mario
Published: April 2024

Basketball is a sport of deceptions, but also of numbers, and the knowledge of its internal logic has benefited for decades from the contributions of colleagues such as Sampaio and Ibáñez-Godoy. Accepting that NBA playoffs are the most demanding competition in our sport, we set two complementary goals for this study: to provide the a priory probabilities associated with field shots based on space and time, and to show the way we followed to calculate them in the R environment.Our analyses allow us to provide the probability distributions associated with field shots based on clock-time and court position, as shown in Table1. In addition, by simple logit models we can see and messure the impact that distances and moments dring the match (period and minute) have on the probability of success.The best basketball players in the world maximize the utility of their shots without being able to escape the space-time logic of the game: the balance between attack and defense comes to light in the form of probabilistic functions with high linearity, especially in terms of space, and points to interesting forward-looking questions. In this sense, our study provides general statistical basis for understanding this logic, allowing in the future to advance in better informed, bayesian study models.
Estudio de tres programas de intervención para la enseñanza del baloncesto en edad escolar. Un estudio de casos
Authors: Gamero Portillo Mª de Gracia , García Ceberino Juan Manuel , Rodrigues Rocha João , Ibáñez Godoy Sergio J. , Feu Sebastián
Published: April 2024

The design of learning tasks in invasion sports is linked to teaching-learning methodologies. The quantitative objective of the study was to analyze the differences and similarities of three intervention programs based on different methodologies, Tactical Games Approach (TGA), Direct Instruction (DI) and Service Teacher's Basketball Unit (STBU) for teaching of school basketball, 148 tasks were analyzed. The qualitative objective was to analyze the decisions made by the teacher during the planning. The pedagogical variables and external training load (eTL) registered in the Comprehensive Training Task Analysis System (SIATE) were analyzed. The intervention programs were compared using the Chi-Square, Kruskal-wallis H statistical tests and the corrected standardized residuals (RTC). Likewise, the association strength of the variables was calculated using Cramer's V coefficients and Epsilon Square. The results indicated similarities between the DI program and the STBU. The TGA teaching program got the highest mean quantification of eTL and eTL × time. The teacher in the service phase uses characteristics of the Teacher Center Approach (TCA) approach in the design of his didactic unit and does not apply his previous ideas in the elaboration of it.
Preditores motivacionais de bem-estar subjetivo em adultos ativos praticantes de ginásio
Authors: Batista Marco , Honório Samuel , Santos Jorge , Serrano João , Petrica João
Published: April 2024

The aim of this study was to determine motivational predictors of subjective well-being in active adults who practice gymnasium, based on the theory of self-determination. 348 subjects participated in this study, 174 of both sexes, between 18 and 67 years old (M=31.83 SD=12.86), with an average of 4.37 years of practice of gym activities, mostly training 3 times a week, with an average of 310.11 minutes weekly. The Basic Psychological Needs Scale in Exercise, the Exercise Behavioral Regulation Questionnaire, the Life Satisfaction Scale, and the Positive and Negative Affects Scale were used. Descriptive statistics, Spearman correlation and linear regression by blocks were elaborated. The highest mean values were recorded for the basic psychological need for autonomy, autonomous motivation and life satisfaction. There were positive correlations between basic psychological needs, autonomous motivation, life satisfaction, positive affect and the volume of minutes of weekly training. Positive correlations were also observed between controlled motivation, amotivation and negative affect. The linear regression analysis allowed us to verify that the basic psychological needs explain a higher percentage value for the variability of data on satisfaction with life and positive affect, compared to motivation.
Influencia de la actividad física en el medio natural sobre la motivación y las necesidades psicológicas básicas de los estudiantes: una revisión sistemática
Authors: Cerrada Nogales Jose Antonio , Navarro Domínguez Benjamín , Giménez Fuentes-Guerra Fco. Javier , Abad Robles Manuel T.
Published: April 2024

The aims of the present study were to carry out a systematic review on the research that carried out some intervention to promote motivation as well as the satisfaction of the basic psychological needs of students, through the physical activity in the natural environment; and describe and analyze them. The PRISMA Declaration guidelines were followed in order to carry out a systematic review, which was conducted in four databases (SportDiscuss, Scopus, Web of Science and Pubmed). 80 studies were identified, with a further four located in the references of other papers. Finally, only 4 manuscripts met the eligibility criteria. The results reveal that the physical activity in the natural environment is postulated as a means favouring the three basic psychological needs and intrinsic motivation.
Proactive Analysis and Detection of Cyber-attacks using Deep Learning Techniques
Authors: Abirami A , Lakshmanaprakash S , Priya R L , Hirlekar Vaishali , Dalal Bhargavi
Published: April 2024

Objectives: This study objective is to create a proactive forensic framework with a classification model to identify the malicious content to avoid cyber-attacks. Methods: In this proposed work, a novel framework is introduced to analyze and detect network attacks before it happens. It monitors the network packet flow, captures the packets, analyzes the packet flow proactively, and detects cyber-attacks using different machine learning algorithms and Deep Convolution Neural network (CNN) technique. The KDD dataset is used in this experiment with 30% for testing and 80% for training. Findings: The simulation results show that the detection percentage of the proposed framework reaches a maximum of 95.92% in different scenarios. It is approximately 10% higher than the existing proactive frameworks for example Gawand’s model, Ahmetoglu’s model and many more. Novelty and applications: The proposed framework is a proactive model which detects the cyber-attack in prior to avoid cyber-attacks. The deep CNN model highly efficient for detecting cyber-attack. Keywords: Proactive Forensic Framework, Deep CNN, Classification Algorithms, Cyber attack detection, Intrusion Detection System
Tissue Fixation | HubMAP | JHU-TMC v2
Authors: Sang Han Kyu , Wu Pei-Hsun , Sunshine Joel , Kiemen Ashley , James Miklhail , Reddy Sashank , Wirtz Denis
Published: April 2024

First and most important - the original tissue sample must be of good quality. Factors such as warm ischemic time, the time delay between tissue excision and fixation, etc. are important. Ideally, tissues should be acquired as close to still being viable as possible, and put into fixative as soon as possiblefollowing excision. Delays lead to cell death, autolysis, and loss of tissue and cell integrity with concomitant losses of immunostaining (e.g., due to proteolysis of the antigen). If acquiring animal tissues, consider performing perfusion fixation before organ/tissue removal if it is an option
Tissue Harvesting | HuBMAP | JHU-TMC v2
Authors: Sang Han Kyu , Wu Pei-Hsun , Sunshine Joel , Kiemen Ashley , Reddy Sashank , Wirtz Denis
Published: April 2024

This protocol describes how to harvest human tissue biopsy and prepare it for histological processes
CODA (part 6): register the nuclear coordinates and construct 3D cell matrix | HuBMAP | JHU-TMC v2
Authors: Sang Han Kyu , Wu Pei-Hsun , Sunshine Joel , Kiemen Ashley , Reddy Sashank , Wirtz Denis
Published: April 2024

Using the registration transformations calculated in low-resolution (as described CODA (part 2): calculate registration on low-resolution tissue images), register the nuclear coordinates generated in CODA (part 5): nuclear coordinate generation
По следам опубликованных работ (на правах рукописи). «Практическое применение научной работы «Промежуточный отчет о проделанной работе специалистов Ведущей Научной Школы развития личной интеллектуальной собственности человека (Знак АЗЪQ) имени «Князя и Графов Священной Римской Империи Зубовых и их потомка графа Гриценко С. Л.»
Authors: Маркосьян Вартан Рафаэлович
Published: April 2024

В научной работе «По следам опубликованных работ (на правах рукописи). «Практическое применение научной работы «Промежуточный отчет о проделанной работе специалистов Ведущей Научной Школы развития личной интеллектуальной собственности человека (Знак АЗЪQ) имени «Князя и Графов Священной Римской Империи Зубовых и их потомка графа Гриценко С. Л.» (признание государством и реализация государством результатов проведенной практической и научной работы)», опубликованной 15 февраля 2024 года в открытом доступе информационно-телекоммуникационной сети «Интернет» Российской Академией Естествознания - сайт https://www.doi.org/, идентификатор цифрового объекта DOI (Digital Object Identifier System) 10.17513/np.583» излагается и описывается, что после публикации указанной работы в информационно-телекоммуникационной сети «Интернет» и направления сведений о публикации с указанием адреса-сайта публикации и номера идентификатора цифрового объекта DOI Президенту Российской Федерации, Руководителю Администрации Президента Российской Федерации, Председателю Правительства Российской Федерации, Председателю Совета Федерации Федерального Собрания Российской Федерации, Председателю и Руководителям фракций Государственной Думы Федерального Собрания Российской Федерации, Секретарю Совета Безопасности Российской Федерации, был в оперативном порядке рассмотрен и принят федеральный закон от 11.03.2024г. № 45-ФЗ «О внесении изменений в отдельные законодательные акты Российской Федерации», разрешающий и регламентирующий использование цифровых финансовых активов (ЦФА) во внешнеэкономической деятельности Российской Федерации с целью нейтрализации негативных последствий экономических санкций, что является практическим применением опубликованной научной работы, - в связи с чем представлены и публикуются документы: регистрационные номера, сопроводительные письма, реестр отправлений, официальные ответы, официальные публикации новостных порталов, - подтверждающие практическое применение государством.
Qualitative nursing research: evidence of scientific validation from a translational perspective
Authors:   University for International Integration of the Afro-Brazilian Lusophony, Cruz Neto João , de Oliveira Lima Ainoã ,   University for International Integration of the Afro-Brazilian Lusophony, Chaves Costa Edmara ,   University for International Integration of the Afro-Brazilian Lusophony
Published: April 2024

This article aims to reflect on scientific validation strategies in qualitative research in the light of translational theory in nursing. It is a reflection based on translational theory applied to nursing in strategies for validating qualitative studies. From this angle, validation is recognized as an adaptable construct, capable of eliciting/favoring an understanding of the subjectivity of the target audience in its relationship with the object of interest/study/research. The potential for advancing the science-profession lies in the interdisciplinary confluence of validation mechanisms, qualitative studies, the translational perspective, and nursing research. This confluence has the capacity to extend beyond theoretical and epistemological aspects. However, it is crucial to emphasize its profound, expressive, and relevant impact on the construction of scientific evidence. This impact aims to enhance the rigor and reliability of qualitative research, thereby bolstering its credibility and applicability in clinical practice.
Multilingüismo, traducción y reescritura en Vladimir Nabokov
Authors:   Universidad de Antioquia, Orozco Wilson
Published: April 2024

Vladimir Nabokov es uno de los creadores más paradigmáticos del siglo XX, además de reconocido escritor multilingüe. Ello le llevó a tener tres etapas: primero la rusa, luego la francesa, hasta pasarse definitivamente a la escritura en inglés, primero con The Real Life of Sebastian Knight, y posteriormente, entre otras, con Lolita, su obra maestra que lo haría famoso internacionalmente. En esta nueva etapa en inglés, acometió igualmente la tarea de traducir su obra escrita previamente en ruso (y viceversa) convirtiéndose así también en un activo ejemplo de autotraductor. Ello, por supuesto, no fue más que la continuación de su primera labor traductora, habiendo vertido ya al ruso autores tan canónicos como Carrol, Rimbaud, Yeats y Verlaine, entre otros; o Tiutchev, Lermontov y Pushkin –con su célebre Eugene Onegin– al inglés. Es de resaltar finalmente que su labor traductora, de enseñanza y de crítica literaria, al mejor modo de la reescritura planteada por André Lefevere, fue utilizada para su propia creación literaria a través de diversas y evidentes formas paródicas.
Análisis bibliométrico de las fuentes alternativas de financiación del emprendimiento
Authors: Manso Laso Javier , Moya Clemente Ismael , Ribes Giner Gabriela
Published: April 2024

Starting up a company requires external financial support until the business is sustainable. In the case of new ventures, turning to traditional sources of financing, such as banks, can be unsuccessful. Therefore, in the early stages of the business, the revenues generated, the assets and the business model are not enough to cover the operational funding needs. Faced with this difficulty in obtaining funds, new financial mechanisms emerge that make possible the necessary liquidity in times of restriction, becoming innovative financial models. This article aims to perform a bibliometric analysis of alternative sources of financing for entrepreneurship based on papers published in the Web of Science database until the year 2022.
El Modelo de Feminidad Franquista a través de la Música. Del Adoctrinamiento a la Transgresión
Authors: López-Hidalgo Cristina , Peinado-Rodrúguez Matilde
Published: April 2024

La historiografía no ha prestado especial atención a las expresiones musicales y folclóricas como nexo entre la historia cultural y la historia política; sin embargo, como trataremos de demostrar en las próximas líneas, dicha conexión será clave como herramienta legitimadora del régimen franquista, proporcionando al sistema político una continuidad fundamental y atemporal, un instrumento privilegiado de mediación entre el pueblo y la estructura política. A través de una revisión de la documentación legislativa, bibliográfica, documental y audiovisual del primer franquismo (1939-1955), con una metodología ensayística, nos hemos propuesto entender, en primer lugar, la instrumentalización de la música, y en concreto el folclore, como herramienta legitimadora de los pilares del estado franquista: clasismo, patriotismo y modelo de feminidad, vehiculizado a través de la Sección Femenina. Como segundo aspecto analizaremos cómo el jazz y la copla, músicas situadas en la alteridad de las fuentes oficiales del franquismo, constituyeron un espacio de libertad expresiva y subversión biopolítica, concluyendo que pudieron convertirse así en la supervivencia desde la otredad, en un modelo de feminidad anti-hegemónica.
From New to Indispensable: How the 2004 Enlargement Reshaped the EU’s Transformative Powers
Authors: Navrátil Matej , Lovec Marko
Published: April 2024

This editorial introduces a thematic issue that examines the consequences of the accession of the Central and East European countries to the EU 20 years onward. The socioeconomic transformation of these countries in the pre-accession period was considered a remarkable success, that was attributed to the EU’s conditionality policy. However, in the post-accession period, when these countries gained full membership rights and began playing a more active political role, they started deviating from some EU norms and rules, against a backdrop of EU crises. This shift has been, notably, reflected in concerns about democratic backsliding and rule of law violations. Nonetheless, the contributions in this issue also underscore that these countries have internalized (both top-down and bottom-up) EU norms and rules to a much greater extent than the focus on conditionality would suggest. Moreover, since Russia invaded Ukraine, Central and East European countries have become entrepreneurs of EU policy and bolstered its transformative power. These findings indicate a need to focus not only on the fundamental shortcomings in these countries—as the attention conferred to the (lack of post-accession) conditionality suggests—but also to consider other factors, such as the quality of the EU’s governance and political system, policy learning, geopolitics, and member states’ domestic politics.
Inferential confusion in the worldview of individuals with Obsessive Compulsive Disorder (OCD): a qualitative approach
Authors: Jensen García Edward , Natera Rey Guillermina
Published: April 2024

Introduction. The Inference-based Approach (IBA) is an etiologic, therapeutic research paradigm regarding inferential confusion (IC) as an exclusive metacognitive process of obsessive compulsive disorder (OCD). IC is the rational tendency of individuals with OCD to underrate abstract data and personal experiences and overrate hypothetical possibilities. IC therefore fosters uncertainty and facilitates the justification of obsessive constructs. IBA has noted that qualitative research on IC and the exploration of IC in non-OCD cognitive constructs are required to refine cognitive and therapeutic OCD models. This could help clarify whether OCD treatment by IBA is overlooking non-obsessive IC habits which, if left untreated, could compromise treatment success. Objective. To identify the possible influence of IC on non-obsessive, cognitive worldview constructs of individuals with OCD and to compare these constructs with those of individuals without OCD. Method. Twenty-five semi-structured, in-depth interviews were conducted, 15 with individuals with OCD and 10 with a comparison group without OCD or OCD symptoms. Data were collected and analyzed using Grounded Theory methodology. Results. IC was identified in the non-obsessive cognitive worldview constructs of every participant with OCD. IC was not identified in the comparative group. Discussion and conclusion. The results suggest that IC affects the rational composition of non-obsessive cognitive worldview constructs of individuals with OCD. The implications this could have for the cognitive and therapeutic models of OCD are discussed.
Russian-Ukrainian War 2014–2024: a Woman in the Rear
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Yarova Yelyzaveta
Published: April 2024

The relevance of this work is expressed in the coverage of the problems faced by women during the Russian-Ukrainian war. This issue is quite acute now, because since 2014, the war with Russia has been going on in Ukrainian lands, namely, on February 24, 2022, active hostilities began throughout the territory of Ukraine. In my research, I would like to draw attention to the specific and special role played by women in the home front during the war, as well as to the problems they face. After all, women are one of the most vulnerable population groups during war. In addition, women are active members of the volunteer movement. After all, as of the beginning of 2014, the army was looted and practically did not exist. And for years, almost without any support from the state, the fighters were provided by volunteers. And now, without exaggeration, almost every Ukrainian has become a volunteer. Whether it is the dissemination of information on social networks, or material assistance with things, or financial assistance to fighters. In recent decades, the idea of gender equality has been increasingly affirmed in Ukrainian society. We see that certain transformative changes are being observed in the gender policy of Ukraine. The successful implementation and regulation of gender relations in society involves the affirmation of the value of gender equality both in society in general and in its various institutions in particular. This is, first of all, the prevention of gender discrimination, ensuring the equal participation of women and men in making socially important decisions (first of all, in the sphere of politics and in general in the labor market), ensuring equal opportunities for women and men to combine professional and family responsibilities, preventing manifestations of gender-based violence, etc. But the problem of sexism is still acute for Ukrainian women. Even public figures and politicians allow themselves sexist expressions. It is not surprising that women also face sexism during protest activity, volunteering and military operations. Undoubtedly, the war between Russia and Ukraine is a war between two cultures, two different civilizations. In a country whose leader says «like it, don’t like it, bear with me, my beauty», which causes an association with the process of rape, both men and women demonstrate a high level of aggression and cruelty. The aggravation of gender stereotypes regarding the role of women in society provokes the aggravation of sexualization and objectification. Even in Aristophanes comedy «Lysistrata» of the 5th century BC, although women are depicted as peacemakers – but according to the plot of the comedy, women refused to have sex with men until they stopped the war.
At the Intersection of Historiography, Source Science and Archivistics: to the Anniversary of Doctor of Historical Sciences, Professor Halyna Kotsur
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Kalakura Yaroslav , Palienko Maryna ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: April 2024

The article highlights the life and creative path of Halyna Heorhievna Kotsur, doctor of historical sciences, professor, acting head of the department of archival studies and special branches of historical science at Taras Shevchenko Kyiv National University, on the occasion of her anniversary. The multifaceted issues of the scientist’s scientific research are analyzed, three main stages of her scientific research activity are singled out, and her contribution to the development of Ukrainian historiography, cultural history, religion, source studies, archeography, and archival science is highlighted. Halyna Heorhievna Kotsur has more than 300 scientific and scientific-methodological works, including 14 individual and collective monographs, more than 40 textbooks and training manuals. She proudly represents the interdepartmental Scientific School of Historiography, Source Studies and Archival Studies of Shevchenko University. Her works are Ukrainian-centric, interdisciplinary in nature and are on the border of many fields of knowledge about history, culture and man. It is noted that H. H. Kotsur is one of the developers and implementers of the Educational Program «Archivistics and Documentation Management», a highly qualified teacher and mentor of student youth, a multifaceted personality, a person of high moral qualities. Her lectures are professionally oriented, creative in nature, based on the latest achievements of historical science and archival science.
Сhronic rhinosinusitis in adult patients with cystic fibrosis receiving CFTR modulators
Authors: Shumkova G. L. , Amelina E. L. , Krasovskiy S. A. , Krylova N. A.
Published: April 2024

Cystic fibrosis-associated chronic rhinosinusitis (CRS) is a separate form of CRS that progresses gradually over the course of patient’s life and worsens with age. The reasons for this are the mechanical congestion of mucus in the paranasal sinuses and the persistence of colonies of pathogenic antibiotic-resistant microorganisms. Therapy with CFTR modulators has resulted in a significant reduction in the severity of CRS. The nature of these changes and the dynamics in the microbial landscape of the upper respiratory tract are not sufficiently explored.

Aim of the article is to highlight various aspects of the impact of CFTR modulators on the course of CRS in adult patients with cystic fibrosis (CF) based on literature data and a number of our own clinical observations. The article presents a series of clinical cases of CRS in adult CF patients treated with CFTR modulators for different periods of time.

Conclusion. During targeted therapy with CFTR modulators, the symptoms of CRS are reversed due to the restoration of normal rheological properties of nasal secretions, the clinical picture improves, and the severity of CRS decreases. However, this type of treatment has no direct effect on the microbial landscape of the respiratory tract and requires additional interventions in the form of local and systemic antibacterial therapy. Therapy with CFTR modulators alters the course of CF in the nasal cavity, as well as in the pharynx and larynx.
Functional activity of the CFTR channel in a patient with the [L467F;F508del]/W1310X genotype
Authors: Krasnova M. G. , Mokrousova D. O. , Efremova A. S. , Melyanovskaya Yu. L. , Sherman V. D. , Bukharova T. B. , Goldshtein D. V.
Published: April 2024

An important factor influencing the severity of cystic fibrosis (CF) and the effectiveness of treatment is the presence of complex alleles in the CFTR gene ≥ 2 variants in one allele. The influence of such alleles on the manifestations of CF has not been sufficiently studied.

The aim of this study was to investigate the effect of the complex allele [L467F;F508del] on the phenotypic manifestations of CF and the efficacy of targeted therapy in an intestinal organoid (IO) model in a patient with the [L467F;F508del]/W1310X genotype.

Methods. Methods for determining the difference in intestinal potentials (IDP), the KO method, and the forskolin test are presented using the medical history of a patient with the [L467F;F508del]/ W1310X genotype as an example.

Results. The patient was diagnosed with progressive disease with obvious deterioration of pulmonary function. The ORKP method showed the absence of chlorine channel function. An assay with a KO culture from intestinal tissue showed a complete loss of functional activity of the chloride channel. In addition, the complex allele [L467F;F508del] is not sensitive to the effect of all tested CFTR modulators.

Conclusion. The complex allele [L467F;F508del] causes a complete loss of functional CFTR protein and is not sensitive to the effect of any of the registered targeted drugs.
The first experience of using magnetic resonance tomography for lung imaging in children with cystic fibrosis: opportunities and prospects
Authors: Mustafin R. I. , Kustova O. V. , Simonova O. I. , Anikin A. V.
Published: April 2024

Cystic fibrosis (CF) is a hereditary disease associated with systemic failure of the exocrine glands. In 95% of the cases, progressive damage to the lung tissue occurs that requires follow-up. The main imaging methods are radiography and computed tomography (CT). Both methods involve ionizing radiation. According to clinical guidelines, a chest X-ray is performed no more than once every 2 years. However, given the high risk of developing inflammatory processes in children with CF, the frequency of radiological examinations may increase significantly. The search for alternative methods without ionizing radiation is in great demand among children with CF. One of these methods is magnetic resonance imaging (MRI).

The aim was to explore the capabilities of MRI for imaging lung tissue in children with CF.

Methods. The study included 12 patients aged 7 to 18 years with newly diagnosed and previously diagnosed CF. All children underwent CT and MRI of the chest.

Results. In all children (100%), chest CT revealed a complex of changes typical of CF: signs of chronic bronchitis, widespread saccular and cylindrical bronchiectasis of various localizations, areas of pulmonary fibrosis, infiltrative changes in the lung tissue. Chest MRI is most effective (100%) in identifying areas of pulmonary fibrosis (thickening of the lung tissue), accumulation of exudate in the lumen of bronchiectasis, and infiltrative changes. In contrast to CT, MRI is less effective in the assessment of bronchitis changes with thickening of the bronchial walls without exudate (83%). A low efficiency of MRI is observed in the visualization of bronchiectasis with a free lumen (without signs of mucostasis).

Conclusion. Radiography and computed tomography remain the main methods for lung imaging in children with CF. However, taking into account the absence of ionizing radiation, the development of the method and the emergence of new sequences, chest MRI can be used effectively for follow-up instead of radiography and CT, reducing the radiation dose received.
Regional experience in monitoring children with cystic fibrosis on targeted therapy in the Republic of Tatarstan
Authors: Pyaterkina O. G. , Karpova O. A. , Begieva G. R. , Zinnatullin I. R. , Zakirov I. I.
Published: April 2024

In connection with the introduction of targeted therapy for cystic fibrosis (CF) into clinical practice, there is a need to study the clinical effectiveness of these drugs and to record their possible side effects in children.

The aim was to present the regional experience of the Republic of Tatarstan in the use of etiopathogenetic therapy (ivacaftor + tezacaftor + elexacaftor) in 41 children diagnosed with CF.

Methods. Before initiation of triple therapy, a comprehensive assessment of body functions was carried out. Monitoring of safety and effectiveness was carried out at 14 days, 1 month, 3 months, 6 months, and 12 months after from the start of therapy.

Results. In the first 2 weeks from the start of therapy, 10 (27%) patients reported mild side effects in the form of increased cough, sputum, and rhinorrhea, 2 (5,4%) patients had skin rashes, and 3 (8,1%) patients had elevated blood aminotransferases. One child developed encephalopathy due to arterial hypertension several months after starting therapy.

Conclusion. Monitoring of the safety of the therapy over 12 months in children with CF showed a satisfactory profile. The therapy was associated with an improvement in the body functions, nutritional status, and quality of life.
Diagnosis and prevention of osteoporosis in children with cystic fibrosis
Authors: Zhekaite E. K. , Odinaeva N. D. , Voronkova N. Yu. , Maksimycheva T. Yu. , Sorokin A. S.
Published: April 2024

Osteoporosis is a metabolic disease of the skeleton characterized by a decrease in bone mass, a disruption of the microarchitecture of bone tissue and, as a result, fractures with minimal trauma. The urgency of the problem of osteoporosis in children with cystic fibrosis arises from the high risk of a decrease in bone mineral density (BMD) in this category of patients.

The aim is to investigate the patterns and mechanisms of bone mineral density reduction in children with cystic fibrosis.

Methods. 100 patients with cystic fibrosis were examined. The control group included 61 healthy children aged 6 to 17 years. Alimentary and biochemical risk factors for the decrease in BMD were analyzed. X-ray densitometry was performed in children over 6 years of age using a DEXXUM device (South Korea). The concentration of calcidiol 25(OH)D and other biochemical parameters in blood were determined using the enzyme immunoassay method.

Results. 62% of patients with CF and 82% of healthy children had normal BMD. The leading factors affecting BMD in patients with cystic fibrosis are: history of meconium ileus, chronic infection with Pseudomonas aeruginosa, lower indicators of nutritional status, and lower lung function (FEV1, %pred). The biochemical markers of osteoremodeling that determine the risk group for osteoporosis in patients with CF are osteocalcin and acid phosphatase. Healthy children who consumed more dietary calcium had better BMD. The effect of dietary calcium intake and vitamin D dose on BMD in patients with CF was not observed.

Conclusion. The features of inflammatory and catabolic processes in cystic fibrosis influence the remodeling processes by reducing osteosynthesis and activating osteoresorption. In both groups of children studied, low nutritional status had a negative effect on BMD.
A Corpus-Based Study on Classical Poetry’s Translation of The Governance of China III from Perspective of Translation Ethics
Authors: Mei Leyun , Ruan Hongmei
Published: April 2024

The Governance of China III is a representative book to shape the national image and enhance national self-confidence. Its English translation is a window for foreign readers to understand China. In the process of translation, translation strategies and methods reflect translators’ choice of different ethical models. This paper takes the English translation of classical poetry in The Governance of China III as the main research object, takes Chesterman’s five ethics models as the theoretical basis, builds a corpus to explore the application of five ethical models in the process of translating classical poetry, and hopes to provide some views on the political publicity translation of classical poetry.
On Basic Word Order: The Comparative Framework, Meta-Definition and the Theoretical Motivation
Authors: Guo Yanding
Published: April 2024

The basic word order is a core term in linguistic typology, and its different theoretical definitions have always been controversial. Firstly, this paper reviews the definitions of basic word order (and dominant order which is extremely related with basic word order) from various schools of thought and compares their definitions through the two levels of “inter-constituent” and “intra-constituent”. Secondly, a meta-definition of basic word order that does not deny or exclude other definitions are provided, namely, the basic word order is the order affect other word order(s) or the word order that holds relevance to predicting other word orders. Thirdly, this paper introduces two research approaches in the typological study of basic word order: causality-based research and correlation-based research. The former focus on the phylogenetical relation of word orders while the later focus on the statistical correlation between word orders. Depending on the different research approaches, the orientation of the definition of basic word order will also differ.
„Átmeneti” kategóriák erősödése az ifjúság vallásos önjellemzésekor
Authors: Bögre Zsuzsanna
Published: April 2024

My study is about changes of self-qualification of the religiosity of the youth. The situation of the youth changed in the 21st century and this drew with itself changes in the ways they see the world. These changes influenced religiosity, too. I have analysed the meanings of the notions used in creating categories of religious self-qualification. I have focused on the meaning of the expression of being “religious in my own way”. What do those using this category of self-qualification exactly mean by that and what are other groups they compare themselves to then? I suspect the existence of a growing rate of transitional categories of self-qualification together with a decline of more exact categories - even though the category of those “not religious” grew and became second biggest behind those of being “religious in my own way”. I hypothesized that the meanings of the notions used in religious self-qualification became blurred as these categories grew in quantity. To see more clearly, I used qualitative research and analysed the meaning of these notions in more detail in the group of those who self-qualified as being “religious in my own way”. The results have shown that youth in transitional categories tendto see themselves as “seekers”. They explained that their aim is to find the meaning of life. They subordinate their quest and their self-qualification to this aim.
Tudás, hatalom és diskurzusok Teun A. Van Dijk kritikai diskurzuselemzésében
Authors: Sarány Orsolya
Published: April 2024

Critical Discourse Analysis (or Critical Discourse Studies – CDA/CDS) examines the relationship between texts, discourses and power, dominance, power abuses and social inequalities. Critical discourse analysis is a multidisciplinary research perspective, which not only examines the interactions between the text, the micro level and its surroundings, the macro level, but its main goal is to uncover social inequalities, expose the forms and modalities of abuse of power. The representatives of CDA are committed to social equality and justice. Present paper presents the work of one of the outstanding representatives of Critical Discourse Analysis, Teun A. Van Dijk, by presenting the history and possibilities of CDA, and also the key elements of Van Dijk’s approach. This study aims to show how knowledge, power and discourse are connected in Van Dijk’s Critical Discourse Analysis.
Mariculture in the Black Sea and its Impact on the Environment According to Satellite Observations
Authors: Ivanov A.Yu. , Klimenko S.K.
Published: April 2024

Satellite monitoring of film pollution on the surface of the Black Sea was carried out. A new source of them has been discovered – fish cages in the Adler-Kudepsta marine area, which produce biogenic films caused by oil and fat additives to fish feed used in industrial mariculture. It was concluded that despite their biogenic origin, they have a negative impact on local marine ecosystems.
The Plant Cover of Rock Dumps of the Cool Cut "Kholbol’dzhinsky" (Republic of Buryatia)
Authors: Rupyshev Yu.A. , Bazha S.N. , Andreev A.V. , Bogdanov E.A. , Danzhalova E.V.
Published: April 2024

The technogenic vegetation of overburden dumps of the Kholboldzhinsky coal mine is considered, represented by one association, three communities, which belong to four 4 unions and orders of the classes Stellarietea mediae, Artemisietea vulgaris, Thero-Salicornietea. An indirect ordination analysis was performed using the principal component method, which made it possible to determine the leading environmental factors of differentiation of syntaxa: moisture and salinity richness.
Communication of Higher Education Institutions in Vietnam
Authors: Nhung Le Thi Bao
Published: April 2024

Communication of higher education institutions are significant in implementing strategic goals and improving institutional governance efficiency; provide students updated information to make appropriate choices and decisions during their learning process; and promptly feedback to contribute to building a better educational and training environment. Communication tools used in higher education institutions are diverse in forms and contents. This studies focuses on two key points, which are policy communications and internal communications implemented by higher education institutions. The theoretical framework has been developed and a survey was conducted to collect opinions of 300 senior students from 3 universities under Hanoi National University, including: University of Foreign Languages; University of Economics; University of Social Sciences and Humanities. The results show that the policy communications of these higher education institutions are not effectively implemented. The findings suggest innovations for managers to improve communication effectiveness to achieve strategic goals and improve governance efficiency in these higher education institutions.
Development Status and Investment Trends of Exchange-Traded Funds in Vietnam
Authors: Kien Dang Trung , Linh Tran Thi Thuy
Published: April 2024

This article is part of research project, code: ĐH2022-TN08-10, sponsored by Thai Nguyen University. We would like to express our gratitude to Thai Nguyen University of Economics and Business Administration and Thai Nguyen University for providing the opportunity and support for our research group to complete our study.
No peace, no sound nutrition
Authors:   African Journal of Food, Agriculture, Nutrition and Development, Oniang'o Ruth
Published: April 2024

Already in Kenya, famine is predicted. There are more than 300,000 Kenyans still in camps for the internally displaced persons (local refugees so to speak). Most of these IDP’s as they re popularly known are in the Rift valley, which is Kenya’s food basket, producing maize, wheat and milk.
Improving halthcare delivery for the many who can ill afford it
Authors:   Great Lakes University of Kisumu (GLUK), Kaseje Daniel
Published: April 2024

In spite of the general increase in the wealth of many countries, one of the most preoccupying concerns of many communities is the existence of large segments of the population who have no access to adequate health care. Increase in global prosperity and technological advancement tends to benefit a minute minority of the global population while the majority is left wallowing in poverty and ill-health, due to uneven playing field in the global market place.