bluuebunny/crossref_metadata_2025 huggingface dataset:
The Trajectory of Motor Deterioration to Death in Parkinson's Disease
Authors: Poonja Sabrina , Miyasaki Janis , Fu Xilai , Camicioli Richard , Sang Tina , Yuan Yan , Ba Fang
Published: August 2021

Background: Motor progression varies even among those with a single diagnosis such as Parkinson's disease (PD) and little is known about the trajectory of motor signs prior to death. Understanding deterioration patterns may help clinicians counsel patients and proactively plan interdisciplinary care, including palliative care. The objective of this study was to examine and describe Unified Parkinson's Disease Rating Scale motor score (UPDRS-III) trajectories at the end of life in PD.

Methods: A retrospective chart review was performed for deceased PD patients who attended the Parkinson and Movement Disorders Program at the University of Alberta for at least 5 years between 1999 and 2018. UPDRS-III scores were recorded for all visits. Trajectory patterns were visualized with Loess curves stratified by sex and age at diagnosis. Piecewise linear models were used to individually model the UPDRS-III scores, and the trajectories obtained were clustered based on their features.

Results: Among the 202 charts reviewed, 84 meeting inclusion criteria were analyzed. The UPDRS-III increased over time regardless of sex and age. Distinct trajectory variations present in PD (e.g., Consistent Deterioration, Stability-Deterioration, Improvement-Deterioration, Deterioration-Improvement-Deterioration) were identified. Twenty-five percent of the patients were classified as Undetermined/Irregular trajectories. In addition, regardless of trajectory type, many patients experienced a steep increase in UPDRS-III approaching death. Those with disease diagnosis after age 65 years had a shorter survival time, compared to PD patients with a younger age of onset.

Conclusion: Our study identified dominant types of motor trajectory in PD that can help clinicians understand their patients' course of illness. This information can help counsel patients regarding the variability in motor deterioration and should alert physicians to recognize a terminal decline. Age of disease onset was correlated with survival time.
Nicotine Enhances Goal-Tracking in Ethanol and Food Pavlovian Conditioned Approach Paradigms
Authors: Angelyn Hailley , Loney Gregory C. , Meyer Paul J.
Published: August 2021

Rationale

Nicotine promotes alcohol intake through pharmacological and behavioral interactions. As an example of the latter, nicotine can facilitate approach toward food- and alcohol-associated stimuli (“sign-tracking”) in lever-Pavlovian conditioned approach (PavCA) paradigms. However, we recently reported that nicotine can also enhance approach toward locations of reward delivery (“goal-tracking”) triggered by ethanol-predictive stimuli when the location of ethanol delivery is non-static (i.e., a retractable sipper bottle).

Objective

To determine whether the non-static nature of the reward location could have biased the development of goal-tracking in our previous study (Loney et al., 2019); we assessed the effect of nicotine in a lever-PavCA paradigm wherein the location of ethanol delivery was static (i.e., a stationary liquid receptacle). Then, to determine whether nicotine’s enhancement of goal-tracking is unique to ethanol-predictive stimuli, we assessed the effect of systemic nicotine on approach triggered by food-predictive stimuli in a lever-PavCA paradigm.

Methods

Long–Evans rats were used in two PavCA experiments wherein a lever predicted the receipt of ethanol (15% vol/vol; experiment 1) or food (experiment 2) into a stationary receptacle. Prior to testing, rats were administered nicotine (0.4 mg/kg subcutaneously) or saline systemically.

Results

In both experiments, nicotine increased measures of goal-tracking, but not sign-tracking.

Conclusion

Nicotine can facilitate approach to reward locations without facilitating approach to reward-predictive stimuli. As such, conceptualization of the mechanisms by which nicotine affects behavior must be expanded to explain an enhancement of goal-tracking by nicotine.
Are People Altruistic When Making Socially Responsible Investments? Evidence From a tDCS Study
Authors: Yang Xiaolan , Meng Wenting , Chen Shu , Gao Mei , Zhang Jian
Published: August 2021

Socially responsible investment (SRI) is an emerging philosophy that integrates social and environmental impacts into investment considerations, and it has gradually developed into an important form of investment. Previous studies have shown that both financial and non-financial motivations account for SRI behaviors, but it is unclear whether the non-financial motive to adopt SRI derives from investors’ altruism. This study uses neuroscientific techniques to explore the role of altruism in SRI decision-making. Given that existing evidence has supported the involvement of the right temporoparietal junction (rTPJ) in altruism and altruistic behaviors, we used transcranial direct current stimulation (tDCS) to temporarily modulate activity in the rTPJ and tested its effect on charitable donations and SRI behaviors. We found that anodal stimulation increased the subjects’ donations, while cathodal stimulation decreased them, suggesting that tDCS changed the subjects’ levels of altruism. More importantly, anodal stimulation enhanced the subjects’ willingness to make SRIs, while cathodal stimulation did not have a significant impact. These findings indicate that altruism plays an important role in SRI decision-making. Furthermore, cathodal stimulation changed the subjects’ perceived effectiveness of charitable donation but not that of socially responsible fund. This result may help explain the inconsistent effects of cathodal stimulation on charitable donations and SRI behaviors. The main contribution of our study lies in its pioneering application of tDCS to conduct research on SRI behaviors and provision of neuroscientific evidence regarding the role of altruism in SRI decision-making.
Effective Organs-at-Risk Dose Sparing in Volumetric Modulated Arc Therapy Using a Half-Beam Technique in Whole Pelvic Irradiation
Authors: Jang Hyunsoo , Park Jiyeon , Artz Mark , Zhang Yawei , Ricci Jacob C. , Huh Soon , Johnson Perry B. , Kim Mi-Hwa , Chun Mison , Oh Young-Taek , Noh O Kyu , Park Hae-Jin
Published: August 2021

Background

Although there are some controversies regarding whole pelvic radiation therapy (WPRT) due to its gastrointestinal and hematologic toxicities, it is considered for patients with gynecological, rectal, and prostate cancer. To effectively spare organs-at-risk (OAR) doses using multi-leaf collimator (MLC)’s optimal segments, potential dosimetric benefits in volumetric modulated arc therapy (VMAT) using a half-beam technique (HF) were investigated for WPRT.

Methods

While the size of a fully opened field (FF) was decided to entirely include a planning target volume in all beam’s eye view across arc angles, the HF was designed to use half the FF from the isocenter for dose optimization. The left or the right half of the FF was alternatively opened in VMAT-HF using a pair of arcs rotating clockwise and counterclockwise. Dosimetric benefits of VMAT-HF, presented with dose conformity, homogeneity, and dose–volume parameters in terms of modulation complex score, were compared to VMAT optimized using the FF (VMAT-FF). Consequent normal tissue complication probability (NTCP) by reducing the irradiated volumes was evaluated as well as dose–volume parameters with statistical analysis for OAR. Moreover, beam-on time and MLC position precision were analyzed with log files to assess plan deliverability and clinical applicability of VMAT-HF as compared to VMAT-FF.

Results

While VMAT-HF used 60%–70% less intensity modulation complexity than VMAT-FF, it showed superior dose conformity. The small intestine and colon in VMAT-HF showed a noticeable reduction in the irradiated volumes of up to 35% and 15%, respectively, at an intermediate dose of 20–45 Gy. The small intestine showed statistically significant dose sparing at the volumes that received a dose from 15 to 45 Gy. Such a dose reduction for the small intestine and colon in VMAT-HF presented a significant NTCP reduction from that in VMAT-FF. Without sacrificing the beam delivery efficiency, VMAT-HF achieved effective OAR dose reduction in dose–volume histograms.

Conclusions

VMAT-HF led to deliver conformal doses with effective gastrointestinal-OAR dose sparing despite using less modulation complexity. The dose of VMAT-HF was delivered with the same beam-on time with VMAT-FF but precise MLC leaf motions. The VMAT-HF potentially can play a valuable role in reducing OAR toxicities associated with WPRT.
Expression of Autophagy and Mitophagy Markers in Breast Cancer Tissues
Authors: Mustafa Mohd Fazirul , Saliluddin Suhainizam Muhamad , Fakurazi Sharida , Tizen Laim Nur Maya Sabrina , Md Pauzi Suria Hayati , Nik Yahya Nik Hasimah , S. Raja Gopal Navarasi , Abdullah Maizaton Atmadini , Maniam Sandra
Published: August 2021

Mitochondria play important roles in regulating cell bioenergetics status and reactive oxygen species (ROS) generation. ROS-induced mitochondrial damage is among the main intracellular signal inducers of autophagy. Autophagy is a cellular catabolic process that regulates protein and organelle turnover, while a selective form of autophagy, mitophagy, specifically targets dysfunctional mitochondrial degradation. This study aims to measure the levels of autophagy, mitophagy, oxidative stress, and apoptosis in invasive breast carcinoma tissues using immunohistochemistry (IHC). Tissue microarrays of 76 patients with breast cancer were stained with six IHC markers (MnSOD, Beclin-1, LC3, BNIP3, Parkin, and cleaved caspase 3). The expression intensity was determined for each tumor tissue and the adjacent tumor-matched control tissues. Intermediate and strong staining scores of MnSOD, Beclin-1, LC-3, BNIP-3, and Parkin were significantly higher in tumor tissues compared to the adjacent matched control. The scoring intensity was further classified into tissues with negative staining and positive staining, which showed that positive scores of Beclin-1 and Parkin were significantly high in tumor tissues compared to other markers. Positive association was also noted between BNIP-3 and Beclin-1 as well as LC-3 and cleaved caspase-3 immunostaining. To our knowledge, this is one of the first studies that measure both mitophagy and autophagy in the same breast cancer tissues and the adjacent matched control. The findings from this study will be of great potential in identifying new cancer biomarkers and inspire significant interest in applying anti-autophagy therapies as a possible treatment for breast cancer.
Current Status of Immune Checkpoint Inhibitor Immunotherapy for Lung Cancer
Authors: Xiong Wei , Zhao Yunfeng , Du He , Guo Xuejun
Published: August 2021

Immunotherapy is a major breakthrough in the treatment of cancer in recent years. Immune checkpoint inhibitors (ICIs) including programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) have been used for different histologic types of cancer including primary lung cancer that represents the most common and fatal cancer globally. Among ICI immunotherapy agents, atezolizumab, durvalumab, ipilimumab, nivolumab, and pembrolizumab are currently used as standard-of-care (SOC) treatment for metastatic or earlier stages of lung cancer. Major issues of ICI immunotherapy in lung cancer comprise the use of immune biomarkers prior to ICI therapy, selection of ICI agents, combination of ICIs/chemotherapy, combination of ICIs/radiotherapy, sequence of tyrosine kinase inhibitor (TKI) targeted therapy and ICI immunotherapy, sequence of chemotherapy and ICI immunotherapy, treatment duration of ICI regimen and ICI therapy for different histopathology, stage, PD-L1, and performance status. Based on the contemporary major clinical trials and authoritative guidelines, the objective of this review is to present an overview of the current status of ICI immunotherapy in lung cancer.
Prevalence of Musculoskeletal Pain and Its Relation With Weight of Backpacks in School-Going Children in Eastern India
Authors: Sankaran Sindhu , John Joseph , Patra Sameer Sekhar , Das Rashmi Ranjan , Satapathy Amit Kumar
Published: August 2021

Background: Recently, heavy school backpacks have become a significant concern among parents and health professionals, as well as the media, but evidence for the same is limited in the Indian context.

Aim: To find the prevalence of musculoskeletal pain among school-going children and its relationship with backpack weight.

Design: Cross-sectional study.

Method: This study was carried out among school-going children from grade 6 to 10 with age of 10 to 16 years from an urban and rural location. Schools were selected randomly from all enlisted schools in the district of Khurdha, Odisha state of India. A structured questionnaire was administered to assess symptoms of musculoskeletal pain. Anthropometric measurements along with backpack weight were taken.

Statistical Analysis: Chi-square test was performed for categorical variables and Student's t-test for continuous variables. Multivariate regression analysis was performed to identify factors with maximum effect on musculoskeletal pain.

Results: The prevalence of musculoskeletal pain was 18.8% in the preceding year. Backpacks weights were higher among children of urban schools as compared with rural areas. Children from urban schools were more likely to have pain than those from rural schools (OR 1.88, 95% CI 1.41–2.49). Those children with a backpack weight more than 10% of body weight had almost twice the risk of musculoskeletal pain compared to backpack weight less than 10% (OR 1.91, 95% CI 1.4–2.6) in univariate analysis where as no significant association was found on multivariate analysis.

Conclusion: The prevalence of musculoskeletal pain was high in school-going children. In children, carrying higher backpack weight, and a higher percentage of the backpack to bodyweight had a significant association with musculoskeletal pain. Gender, height, body mass index, and backpack weight to body weight > 10% had no association with musculoskeletal pain.
Exploration of Hospital Inpatients' Use of the Verbal Rating Scale of Pain
Authors: Bosdet Luke , Herron Katie , Williams Amanda C. de C.
Published: August 2021

Background: Assessment of pain largely relies on self-report. Hospitals routinely use pain scales, such as the Verbal Rating Scale (VRS), to record patients' pain, but such scales are unidimensional, concatenating pain intensity and other dimensions of pain with significant loss of clinical information. This study explored how inpatients understand and use the VRS in a hospital setting.

Methods: Forty five participants were interviewed, with data analysed by thematic analysis, and completed a task concerned with the VRS and communication of other dimensions of pain.

Results: Participants anchored their pain experience in the physical properties of pain, its tolerability, and its impact on functioning. Their relationship to analgesic medication, personal coping styles, and experiences of staff all influenced how they used the VRS to communicate their pain.

Conclusion: Participants grounded and explained their pain in semantically similar but idiosyncratic ways. The VRS was used to combine pain intensity with multiple other elements of pain and often as a way to request analgesic medication. Pain scores need to be explored and elaborated by patient and staff, content of which will imply access to non-pharmacological resources to manage pain.
Operative Management of Neonatal Lymphatic Malformations: Lesson Learned From 57 Consecutive Cases
Authors: Scuglia Marianna , Conforti Andrea , Valfrè Laura , Totonelli Giorgia , Iacusso Chiara , Iacobelli Barbara D. , Meucci Duino , Viggiano Milena , Fusaro Fabio , Diociaiuti Andrea , Morini Francesco , El Hachem May , Bagolan Pietro
Published: August 2021

Aim of the study: Lymphatic malformations (LMs) are rare entities, sometimes difficult to treat, that may be life-threatening when intricately connected to airway structures. Invasive treatments are occasionally required, with sclerotherapy considered the treatment of choice and surgery as a second-line approach. The aim of the present study was to evaluate our multidisciplinary team experience in treating newborns affected by LMs requiring operative management, while defining early outcomes.

Methods: Retrospective review of all consecutive patients admitted for LMs requiring operative management between January 2000 and January 2019. Patients were mainly characterized based on anatomical district of the LM (and further stratified based on the development of respiratory distress), need for tracheostomy, number of sclerotherapies, indication for surgery, and residual disease beyond the 1st year. Morbidity and mortality were also evaluated. Fisher exact test and Mann–Whitney test were used as appropriate. Statistical significance was set at p < 0.05.

Results: Fifty-seven patients were included in the study, 36 with cervicofacial and/or mediastinal LMs and 21 with LMs of other anatomical districts. Due to the risk of developing respiratory distress at birth, patients with cervicofacial and/or mediastinal LMs were divided into two groups (8/36 group A vs. 28/36 group B). Group A patients are at higher risk for tracheostomy (7/8 group A vs. 1/28 group B, p = 0.0001) and more often require surgical reduction of the residual lymphatic abnormality (5/8 group A vs. 4/28 group B, p = 0.013). They also require sclerotherapies more often, but the difference is not statistically significant (8/8 group A vs. 19/28 group B, p = 0.15). Patients with cervicofacial/mediastinal LMs frequently suffer from persistent residual disease beyond the 1st year of life, significantly more often in group A (7/8 group A vs. 12/28 group B, p = 0.043).

Conclusion: LMs are rare conditions with potential life-threatening behavior. Their intrinsic clinical complexity requires a multidisciplinary approach to the affected patients. Planning a long-term follow-up is essential because of the late-term problems those patients may experience.
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
Authors: Espinosa-Oliva Ana M. , García-Miranda Pablo , Alonso-Bellido Isabel María , Carvajal Ana E. , González-Rodríguez Melania , Carrillo-Jiménez Alejandro , Temblador Arturo J. , Felices-Navarro Manuel , García-Domínguez Irene , Roca-Ceballos María Angustias , Vázquez-Carretero María D. , García-Revilla Juan , Santiago Marti , Peral María J. , Venero José Luis , de Pablos Rocío M.
Published: August 2021

Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In this sense, peripheral inflammation, especially the originated in the colon, is emerging as a predisposing factor for suffering this disease. We have largely studied the pleiotropic roles of galectin-3 in driving microglia-associated immune responses. However, studies aimed at elucidating the role of galectin-3 in peripheral inflammation in terms of microglia polarization are lacking. To achieve this, we have evaluated the effect of galectin-3 deletion in two different models of acute peripheral inflammation: intraperitoneal injection of lipopolysaccharide or gut inflammation induced by oral administration of dextran sodium sulfate. We found that under peripheral inflammation the number of microglial cells and the expression levels of pro-inflammatory mediators take place specifically in the dopaminergic system, thus supporting causative links between Parkinson’s disease and peripheral inflammation. Absence of galectin-3 highly reduced neuroinflammation in both models, suggesting an important central regulatory role of galectin-3 in driving microglial activation provoked by the peripheral inflammation. Thus, modulation of galectin-3 function emerges as a promising strategy to minimize undesired microglia polarization states.
Dual-Mode Memristor Synaptic Circuit Design and Application in Image Processing
Authors: Wang Rui , Mu Zhicheng , Sun Hui , Wang Yuyue
Published: August 2021

Memristor is a kind of synaptic element with nanometer size and continuously variable memristance. The bridge synaptic circuit constructed by the memristor has a simple structure and precise control. In practice, because of the non-linear characteristics of memristor, it is not easy to control synaptic circuit and errors in weights appear. Therefore, a novel memristor synaptic circuit is proposed in this paper, called the dual-mode memristor bridge synaptic neural network. The proposed method can make the weights more linear by controlling the input voltages and make the outputs more linear by using symmetrical positive and negative pulses. Therefore, the proposed synaptic circuit is easier to be controlled. In this paper, the numerical simulations are conducted and verify the feasibility. Furthermore, the simulation experiments are conducted for edge extraction of grayscale birds’ images in the airport for bird recognition applied for the bird repelling applications.
The Consequences of COVID-19 Toward Human Growth: The Role of Traumatic Event and Coping Strategies Among Indonesian Sample
Authors: Kaloeti Dian Veronika Sakti , Ardhiani Lusi Nur , Stück Marcus
Published: August 2021

COVID-19 has brought a massive psychological impact on individuals' life. The current study sets a significant purpose to test the model whether post-traumatic stress and coping strategies affect stress-related growth regarding the COVID-19 event. One hundred and ninety-nine participants have participated in an online survey in the period of lockdown. The proposed hypotheses model is further tested using PLS-SEM. The first model explains a significant moderate, 46% amount of variance for stress-related growth. With gender as moderator, the second model explains a significant 29% amount of variance for stress-related growth, which is also moderate. This study shows that active coping strategies and positive affirmation significantly influence individual stress-related growth. The trauma event (COVID-19) does not significantly affect growth. Women experience trauma compared to men, besides active coping with the COVID-19 situation is higher in men than women. Using the Bio-centric perspective, having a positive connection through acceptance and awareness of the situation, self-care, and affective interaction with others would develop growth regarding traumatic situations. Further, interventions about coping skills and positive affirmations are essential to give, especially to vulnerable groups such as women.
The Role of the Negative 3-H Trio in Second Language Education
Authors: Chu Jing , Zeng Xiaoxia
Published: August 2021

Language has been proven to strongly affect different aspects on one's life/career including his/her identity and interpersonal communication skills beyond the immediate context. Given this, now proper discourse and interlocutor's emotions are highlighted in academia. However, few studies (if any) have explored the role of negative stressors and constructs in L2 classroom discourse and interpersonal communication competency. To fill this yawning lacuna, the present study provided a glance at the impact of three negative language aspects of hate, hurt, and harm (also called negative 3-H trio) on L2 education. Moreover, it presents the definitions, origins (positive psychology, positive peace psychology), dimensions, and applications of each aspect. Finally, some implications and future directions are suggested to avid scholars in L2 and mainstream education.
Impact of COVID-19 on Lifestyle, Personal Attitudes, and Mental Health Among Korean Medical Students: Network Analysis of Associated Patterns
Authors: Yun Je-Yeon , Kim Ju Whi , Myung Sun Jung , Yoon Hyun Bae , Moon Sang Hui , Ryu Hyunjin , Yim Jae-Joon
Published: August 2021

The current COVID-19 pandemic have affected our daily lifestyle, pressed us with fear of infection, and thereby changed life satisfaction and mental health. The current study investigated influencing cascade of changes during the COVID-19 among the lifestyle, personal attitudes, and life (dis)satisfaction for medical students, using network-based approaches. This cross-sectional survey used self-reports of 454 medical students during June and July of 2020. Depressive mood, anxiety, and intention to drop out of school were observed in 11.9, 18.5, and 38.3% of medical students, respectively. Directed acyclic graph that estimated directional propagation of the COVID-19 in medical students' daily lives initiated from the perception of unexpected event, propagated to nervous and stressed feeling, trouble relaxing, feeling like a failure, and were followed by trouble concentrating, feeling loss of control for situation, and fear of infecting colleagues. These six features were also principal mediators within the intra-individual covariance networks comprised of changed lifestyle, personal attitude, and mental health at COVID-19 pandemic. Psychosocial supports targeting nervousness, trouble relaxing and concentrating, fear of spreading infection to colleagues, feelings of a failure or loss of situational control are required for better mental health of medical students during the COVID-19 pandemic.
Testing Scalability of a Diabetes Self-Management Intervention in Northern Mexico: An Ecological Approach
Authors: Aceves Benjamin , Denman Catalina A. , Ingram Maia , Torres Jose Francisco , Nuño Tomas , Garcia David O. , Madhivanan Purnima , Rosales Cecilia B.
Published: August 2021

Background: Type 2 diabetes mellitus (T2DM) has become a major issue in Mexico, reporting almost 100,000 attributable deaths in 2016. Low-income Mexican citizens who face various issues associated with T2DM, including the lack of access to self-management services, are particularly affected by the condition. Health centers have been designated to serve T2DM patients by providing resources on chronic disease prevention. Meta Salud Diabetes (MSD) is a self-management intervention developed to address cardiovascular complications and other health issues within the T2DM population, which have been proven effective and useful for health centers. The intervention was designed for T2DM support groups—grupos de ayuda mutua (GAMs) located within health centers.

Methods: From February to June 2019, a binational research team conducted a test scale-up study in Northwest Sonora under the Ministry of Health utilizing the Institute for Healthcare Improvement Framework for scaling up health interventions. Investigators worked in collaboration and trained 19 stakeholders from a regional health system identified from various ecological levels on MSD and implementation process.

Results: All five GAMs within the regional health system received and completed the intervention. In total, 72 participants were enrolled with behavioral and biological [HbA1c, blood pressure, body mass index (BMI)] measures taken at baseline. Post-intervention measurements were taken from 72% of participants who completed the intervention. Statistical analysis demonstrated improved behavioral and biological measures when comparing baseline to post-intervention, specifically statistically significant improvements in HbA1c and sugar-sweetened beverage consumption. Implementation fidelity (IF) measures indicated extensive adherence to the intervention curriculum, and moderators specifically demonstrated influences on implementation. Stakeholders from various ecological levels provided support to those facilitating the MSD intervention by allotting time and resources to properly prepare for sessions. An implementation coordinator from the regional health office assisted MSD facilitators by resolving barriers to implementation and worked toward federal accreditation for GAMs to receive additional funding.

Conclusion: Results provide evidence for using regional health systems as a scalable unit when implementing chronic disease self-management interventions state- and nationwide. This study will help inform future efforts to scale up the health intervention in various states throughout Mexico.

Clinical Trial Registration:www.ClinicalTrials.gov; https://www.clinicaltrials.gov/ct2/show/NCT02804698?term=NCT02804698&draw=2&rank=1, identifier: NCT02804698.
Predictive Analysis of Health/Physical Fitness in Health-Promoting Lifestyle of Adolescents
Authors: Liu Hao , Liu Yiwen , Li Bin
Published: August 2021

Objective: Explore the correlation and predictive power of health physical fitness on health-promoting lifestyle of adolescents to provide an important reference for reform in middle school physical education classroom teaching.

Methods: Taking some junior and senior high school students in Nanchong City of Sichuan Province as survey objects, a stratified random sampling method was used to carry out a health/fitness test and conduct a questionnaire survey. SPSS17.0, amos 21.0, and other statistical analysis software were used to process the relevant data.

Results: (1) Male adolescents had 14.4% predictive power for their overall health-promoting lifestyle through the combined effects of cardiopulmonary endurance, muscle strength, and explosive strength, while female adolescents had 16.8% predictive power for their overall health-promoting lifestyle through the combined effects of cardiopulmonary endurance, flexibility, and body mass index (BMI). (2) Ten percent of the variation in the health-promoting lifestyle of men under 14 years old was caused by the combined effects of muscle endurance and muscle strength, while 14.4% of the variation in the health-promoting lifestyle of female adolescents was caused by the combined effects of muscle endurance, muscle strength, flexibility, and cardiopulmonary endurance. (3) Some 10.9 and 17.6% of the variation in health-promoting lifestyle of male and female adolescents aged between 14 and 17 was caused by the combined effects of cardiopulmonary endurance, muscle strength, and flexibility, respectively. (4) Some 20.7% of the variation in health promoting lifestyle of male adolescents aged 17 years or above was caused by cardiopulmonary endurance, explosive force, and muscle endurance, while 16.8% of the variation in health-promoting lifestyle of female adolescents was caused by the combined effect of cardiopulmonary endurance, BMI, and muscle endurance.

Conclusion: Health and physical fitness of adolescents can significantly predict their health-promoting lifestyle, and the predictive power and typical correlation between them are affected by demographic factors.
Using AquaCrop as a Decision-Support Tool for Small-Scale Irrigation Systems Was Dictated by the Institutional and Market Incentives in Ethiopia
Authors: Biazin Birhanu , Wondatir Solomon , Tilahun Gebeyaw , Asaro Nuredin , Amede Tilahun
Published: August 2021

The threat of water scarcity in sub-Saharan Africa is exacerbated by the expanding agricultural water needs, increasing climate variability and inappropriate land use. It calls for technological and institutional innovations to improve water productivity, while sustaining the resources base. This study was undertaken to examine the effect of deficit and supplementary irrigation for staggered production of potato driven by market opportunities at different periods in northeastern Ethiopia. We used potato (Solanum tuberosum) to demonstrate AQUACrop as a tool for improving water productivity during Belg (short) and Meher (long) rainfall seasons. A field experiment was undertaken using supplementary irrigation at different levels of potato crop water satisfaction (50% ETc, 75% ETc, 100% ETc and rainfed conditions) during the Belg (February–May 2020) and Meher (July–October 2020) seasons. Upon proper calibration of AquaCrop for the local potato variety (Belete), long-term simulations revealed that the mean net irrigation requirements were 249 mm during Belg season while the probability of applying supplementary irrigation during Meher was <10% when the effective precipitation was greater than the crop water requirement (ETc) in more than 75% of the years. Although there was significantly higher potato tuber yield from the 100% ETc than that from the 75% ETc, the latter had higher water supply efficiency than the former. Long-term simulations further revealed that the number of rainfall days was more important than the amount of rainfall during the growing period. We engaged water users' associations to employ the recommendation and enforce supplementary irrigation as predicted by the model and we present farmers' response and reasons for resistance toward water saving approaches. Hence, we concluded that 50% ETc and 75% ETc irrigation levels can still be recommended upon proper scheduling to address long dry spells, especially during the middle growth stages in the face of irrigation conflict. However, the institutional settings and market incentives associated with it are the major drivers of adopting improved irrigation water management practices.
Conservation Strip Tillage Leads to Persistent Alterations in the Rhizosphere Microbiota of Brassica napus Crops
Authors: Rathore Ridhdhi , Dowling David N. , Forristal Patrick D. , Spink John , Cotter Paul D. , Germaine Kieran J.
Published: August 2021

Microbes play vital roles in many soil ecosystem functions and services, which are crucial for agricultural productivity. Among different agricultural management practices, soil tillage methods can result in changes in a soil's physical, chemical and biological properties, including the soil microbiome. In addition, crop type and the plant developmental stage are important drivers of rhizosphere bacterial microbiota structure and composition. Here, we have used high-throughput, 16S amplicon sequencing to explore the rhizosphere bacterial structure and composition of Brassica napus (winter oilseed rape) in two contrasting tillage practices; conventional-plough based tillage and conservation strip tillage, over three different plant growth stages (vegetative, flowering and harvesting stage). This was the first year that conservation strip tillage was used in this field, as in previous years plough based tillage practices has been used. Our findings show that tillage and growth stages were important determinants of microbial community structure and composition, but the effect of tillage became stronger at plant maturity. The combined effect of conservation strip tillage and harvesting stage had a impact on the rhizosphere microbiota selection. The rhizosphere bacterial community of winter oilseed rape under conservation strip tillage was different to that under conventional tillage. Our data suggests that different tillage regimes created distinct ecological niches that selected different microbiota with potential consequences for the ecosystem services provided to the plants and the soil environment.
Amplifying Agroecological Farmer Lighthouses in Contested Territories: Navigating Historical Conditions and Forming New Clusters in Japan
Authors: McGreevy Steven R. , Tamura Norie , Kobayashi Mai , Zollet Simona , Hitaka Kazumasa , Nicholls Clara I. , Altieri Miguel A.
Published: August 2021

Individual agroecological farms can act as lighthouses to amplify the uptake of agroecological principles and practices by other farmers. Amplification is critical for the upscaling of agroecological production and socio-political projects emphasizing farmer sovereignty and solidarity. However, territories are contested spaces with historical, social, cultural, and economic contexts that can present challenges to the effectiveness of farmer lighthouses in catalyzing localized agrarian change. We explore these amplification dynamics through fieldwork in a particular region of Japan employing interviews and data derived from an assessment of nine farms using ten amplification indicators. The indicators include social organization, participation in networks, community leadership, and degrees of dependency on policies or markets among others, as well as degree of adoption of on-farm agroecological practices, all of which capture farmer lighthouses' potential to amplify territorial upscaling. At the same time, we trace the historical development of a previous generation of Japanese farmer lighthouses practicing organic agriculture in alignment with agroecological principles that experienced, to varying degrees, push-back, co-option, and successful territorialization in rural communities. We find that many of the same social and cultural territorial dynamics are still influential today and affecting the amplifying effect of agroecological farmer lighthouses, but also find examples of new clustering around lighthouses that take advantage of both the historical vestiges of the previous generation's efforts as well as contemporary shifts in practice and agrarian orientation. This research calls for a detailed dissection of the dynamic and contrasting processes of agroecological territorialization and the ways in which diverse contexts shape agroecological upscaling.
Economic Considerations for Advancement Through the Progressive Control Pathway: Cost–Benefit Analysis of an FMD Disease-Free Zone in Punjab Province, Pakistan
Authors: Lyons Nicholas A. , Afzal Muhammed , Toirov Farrukh , Irshad Aamer , Bartels Chris J. M. , Rushton Jonathan
Published: August 2021

Foot-and-mouth disease (FMD) is a priority disease of livestock in Pakistan, which was classified in stage 2 of the Progressive Control Pathway (PCP-FMD) in 2015, aiming to reduce disease impact. Further progression requires efforts to reduce viral circulation that may ultimately result in being awarded official disease-free status by the World Organisation for Animal Health [Office International des Epizooties (OIE)]. Typically, FMD control is reliant on the extensive use of vaccines, requiring careful consideration of the costs and benefits to ensure investment is likely to provide a positive return. This study conducted a cost–benefit analysis (CBA) for a proposed zone within Punjab Province, Pakistan. Benefits were assumed to come from averted production losses and treatment costs and the costs based on typical measures required for establishing a disease-free zone. To estimate the impact of FMD at the farm level, models were created to estimate effects on milk production, offtakes, and changes in herd value over a 5-year period with different parameters used to represent the production systems present. Control strategy costs incorporated aspects of vaccination, surveillance, sanitary measures, program management, stakeholder engagement, preparatory studies, training, and capacity building. The results indicated a median benefit–cost ratio of 1.03 (90% central range 0.37, 1.63) with a median net present value of 1.99 billion Pakistan Rupees (90% central range −37.7, 37.0). The greatest cost was due to vaccination at 56%, followed by sanitary measures (including implementing and maintaining an animal ID system and quarantine stations around the zone) at 41%. Although the median benefit–cost ratio and net present value indicated that investment is likely to generate a positive return, the large variation indicates caution in interpreting the results and it is possible that an increase in animal value through new export markets will be required. Further refinement in our knowledge of disease impact and the details of the control strategy are needed. Moreover, there are implications regarding vaccine security, since the strategy is reliant on the steady provision of quality vaccines in order to achieve the anticipated benefits, raising important issues on vaccine availability for countries to maintain lucrative export markets for FMD.
Case Report: A Case Series Linked to Vitamin D Excess in Pet Food: Cholecalciferol (Vitamin D3) Toxicity Observed in Five Cats
Authors: Vecchiato Carla G. , Delsante Costanza , Galiazzo Giorgia , Perfetti Simone , Pinna Carlo , Sabetti Maria C. , Zagnoli Laura , Biagi Giacomo , Pietra Marco
Published: August 2021

Cholecalciferol (vitamin D3) toxicity caused by defective pet food formulations is a rare occurrence described in cats. Nevertheless, it poses a health risk, even though the affected pet food is not fed as the sole diet. Excessive vitamin D3 intake might cause hypercalcemia and soft tissue mineralization, which are findings that prompt clinicians to further investigate the feasible etiology. This case series describes the effects of an extremely high vitamin D3 intake in five young cats caused by the consumption of a fish-based complementary kitten pet food (KPF) that was fed to all of the cats as part of their diet (cases 1, 2, and 3) or eaten exclusively (cases 4 and 5). Due to the different amounts of vitamin D3 consumed, diagnostic examinations showed different degrees of severity of hypercalcemia and azotemia as well as different radiographic findings in cases where diagnostic imaging was performed (cases 2, 4, and 5). All of the cats were treated by withdrawing the affected food and providing medical management of the hypercalcemia. All of the cats recovered, except for two persistent azotemic cats, which developed chronic kidney disease. The goal of this case series is, therefore, to describe the occurrence and resolution of an acute vitamin D3 toxicity due to the highest amount of dietary vitamin D3 intake that has ever been described in domestic cats.
First Coronavirus Active Survey in Rodents From the Canary Islands
Authors: Monastiri Abir , Martín-Carrillo Natalia , Foronda Pilar , Izquierdo-Rodríguez Elena , Feliu Carles , López-Roig Marc , Miquel Jordi , Ar Gouilh Meriadeg , Serra-Cobo Jordi
Published: August 2021

Since the beginning of the 21st century five new coronaviruses inducing respiratory diseases in humans have been reported. These emergences has promoted research on coronaviruses in wildlife. We started the first eco-epidemiological study to screen the presence of coronaviruses circulating in mice and rats of four Canary Islands. Between 2015 and 2019, we obtained fecal samples of three rodent species (150 Mus musculus, 109 Rattus rattus and 1 Rattus norvegicus) captured in urban and rural areas. Fecal samples were analyzed by nRT-PCR and the resulting sequences were compared to known diversity using Bayesian phylogenetic methods. We only found coronavirus RNA in house mice from El Hierro (10.53%), Tenerife (7.02%) and Lanzarote (5.26%) islands. All coronaviruses detected belong to the species Murine coronavirus belonging to the genus Betacoronavirus and subgenus Embecovirus, being all positive house mice captured in anthropogenic environment. The phylogenetic analysis shows that murine coronaviruses from the Canary Islands are related to European murine coronaviruses. Albeit data are still scarce in the region, the most probable origin of M. coronavirus present in the Canary Islands is continental Europe. According to temporal Bayesian phylogenetics, the differentiation between Canary and continental viruses seems to be quite recent. Moreover, murine coronaviruses from El Hierro, Tenerife and Lanzarote islands tend to segregate in different clades. This enlightens the potential role of rodents or other possibly invasive species in disseminating infectious diseases to remote places through exchanges with the continent. It is important to consider these aspects in the sanitary control of islands, for health and biodiversity preservation concerns.
Back to the Countryside: Rural Development and the Spatial Patterns of Population Migration in Zhejiang, China
Authors: Tong Weiming , Lo Kevin
Published: August 2021

This study examines how rural development in China shapes new trends in population migration. Using first-hand, village-level data from Zhejiang—an economically developed province in China—we investigated the patterns and influencing factors of population migration between rural and urban areas. We conceptualized three types of migration in rural areas: rural out-migration, rural in-migration, and rural return-migration. First-hand data were collected from 347 villages. The results show that although rural out-migration remains the dominant form of migration, rural in-migration and return-migration are also common, and the latter two are positively correlated. Further, we found evidence to support the conclusion that rural economic, social, and spatial development encourages rural in-migration and return-migration but does not have a significant impact on rural out-migration. Therefore, it is foreseeable that rural in-migration and return-migration will become increasingly common in China.
Interactions between Food Environment and (Un)healthy Consumption: Evidence along a Rural-Urban Transect in Viet Nam
Authors: Nguyen Trang , Pham Thi Mai Huong , van den Berg Marrit , Huynh Thi Thanh Tuyen , Béné Christophe
Published: August 2021

There is limited evidence on food environment in low and middle-income countries (LMICs) and the application of food environment frameworks and associated metrics in such settings. Our study examines how food environment varies across an urban-peri-urban-rural gradient from three sites in North Viet Nam and its relationship with child undernutrition status and household consumption of processed food. By comparing three food environments, we present a picture of the food environment in a typical emerging economy with specific features such as non-market food sources (own production and food transfers) and dominance of the informal retail sector. We combined quantitative data (static geospatial data at neighborhood level and household survey) and qualitative data (in-depth interviews with shoppers). We found that across the three study sites, traditional open and street markets remain the most important outlets for respondents. Contrary to the common concern that urban households are the major consumers of processed foods, peri-urban and rural areas on average had higher consumption of ultra-processed foods than in urban areas. The low price levels of processed foods and the presence of processed foods even among the traditional convenience stores, those in closest proximity to the rural households, offer potential explanations of this result. Regarding undernutrition, low retail diversity and a household’s dependence on own production have important implications for the high prevalence of child undernutrition in rural areas. Our findings add to the current discussion on the critical role of the food environment on nutrition, such as the potential link between economic marginalization and access to food, and the role of food supply channels in consumption of processed foods.