bluuebunny/crossref_metadata_2025 huggingface dataset:
Upper Plate and Subduction Interface Deformation Models in the 2022 Revision of the Aotearoa New Zealand National Seismic Hazard Model
Authors: Van Dissen Russ J. , Johnson Kaj M. , Seebeck Hannu , Wallace Laura M. , Rollins Chris , Maurer Jeremy , Gerstenberger Matthew C. , Williams Charles A. , Hamling Ian J. , Howell Andrew , DiCaprio Christopher J.
Published: November 2023

As part of the 2022 revision of the Aotearoa New Zealand National Seismic Hazard Model (NZ NSHM 2022), deformation models were constructed for the upper plate faults and subduction interfaces that impact ground-shaking hazard in New Zealand. These models provide the locations, geometries, and slip rates of the earthquake-producing faults in the NZ NSHM 2022. For upper plate faults, two deformation models were developed: a geologic model derived directly from the fault geometries and geologic slip rates in the NZ Community Fault Model version 1.0 (NZ CFM v.1.0); and a geodetic model that uses the same faults and fault geometries and derives fault slip-deficit rates by inverting geodetic strain rates for back slip on those specified faults. The two upper plate deformation models have similar total moment rates, but the geodetic model has higher slip rates on low-slip-rate faults, and the geologic model has higher slip rates on higher-slip-rate faults. Two deformation models are developed for the Hikurangi–Kermadec subduction interface. The Hikurangi–Kermadec geometry is a linear blend of the previously published interface models. Slip-deficit rates on the Hikurangi portion of the deformation model are updated from the previously published block models, and two end member models are developed to represent the alternate hypotheses that the interface is either frictionally locked or creeping at the trench. The locking state in the Kermadec portion is less well constrained, and a single slip-deficit rate model is developed based on plate convergence rate and coupling considerations. This single Kermadec realization is blended with each of the two Hikurangi slip-deficit rate models to yield two overall Hikurangi–Kermadec deformation models. The Puysegur subduction interface deformation model is based on geometry taken directly from the NZ CFM v.1.0, and a slip-deficit rate derived from published geodetic plate convergence rate and interface coupling estimates.
Análisis de estrategias aplicadas por emprendimientos agroganaderos del Chaco central. Año 2020
Authors: Peña Cardozo Angel Ramón , Oporto Giménez Adán Ariel , Ovelar Benítez Hugo Miguel , Torales Solís Genaro Marcial , León Fretes Leticia Lorena
Published: November 2023

Este trabajo tiene como problemática el estudio de los lineamientos estratégicos de emprendimiento agro ganaderos del Chaco Central. La Metodología utilizada en este trabajo ha tenido un enfoque cuali-cuantitativo, con un alcance exploratorio, aplicando entrevistas en profundidad a un total de diez encargados de las fincas agropecuarias. La principal actividad es la producción carne bovina. EL 47% de las fincas es destinado a la pastura, 2% a cultivo agrícola y 2% a la infraestructura, el espacio dedicado a Bosque representa el 49%. Las estrategias más adecuadas para lograr un mayor desarrollo incluyen aplicar registros adecuados para medir y contralar el desarrollo de los animales a fin de entregar animales con mejor registro de peso en una época de venta adecuada. Aplicar un plan de vacunaciones para evitar enfermedades en el ganado. Se requiere el control de malezas por su implicancia en la dieta de los animales y por ende su ganancia de peso, por ello es necesario contar con un plan de manejo del suelo. Se hace necesaria la construcción de reservorios de agua y alimentos para mitigar la acción del clima. Por último, la capacitación del personal es un aspecto que se impone para un mejor manejo de las parcelas, del agua y el alimento. Más que una capacitación formal se buscaría la participación de charlas realizadas por entes estatales o privados que ofrezcan asistencia técnica.
Enhancing Health through Built Environment Improvement: A Southern Nevada Health Impact Assessment Case Study
Authors: Gakh Maxim , Coughenour Courtney , Strickler Emily , McDonough Megan R. , Kumra Priyambda , Pharr Jennifer R. , Bungum Timothy , Bungum Nicole , Meacham Mindy
Published: November 2023

Background: Health Impact Assessment (HIA) is a public health tool to evaluate how choices made outside the health sector can affect health. HIAs are utilized in transportation, housing, planning, and other fields. Since the built environment can impact community health outcomes, including physical activity rates, injuries, and overweight and obesity, an interdisciplinary team composed of public health, planning, transportation, and land use professionals conducted an HIA in Las Vegas, Nevada.
Methods: The HIA consisted of (1) screening, (2) scoping, (3) assessment, (4) recommendations, (5) reporting, and (6) monitoring and evaluation. It examined proposed physical improvements to a 0.66 mile stretch of a major arterial roadway in the City of Las Vegas where nearby residents experience many health inequities. Collection and analysis of land use and survey data, analysis of secondary data, and literature reviews were completed to predict potential health effects produced by built environment changes. Stakeholder feedback informed each HIA step.
Results: The HIA generated recommendations to improve physical activity, reduce pedestrian and bicyclist injury rates, and decrease obesity and overweight prevalence, by presenting “good,” “better,” and “best” physical infrastructure improvements. The process and resulting recommendations enhanced collaboration among health and nonhealth sectors.
Conclusions: Data and analysis revealed that the proposed changes could improve walkability and bikeability and reduce pedestrian and bicyclist injury. By encouraging active transportation through bicycling and walking, the plan could, over time, contribute to reduced overweight and obesity. The HIA facilitated inter-sector cross collaboration and the integration of health into future decision-making.
A Case Study Analysis of how Products Might be Designed to Promote Health
Authors: Sigler Brittany E. , Pollack Porter Keshia M. , Thompson Lindsay , Engineer Cyrus Y. , Singer Sara , Gaskin Darrell
Published: November 2023

Background: Consumer technology products are changing lifestyle behaviors like how we eat, how we sleep, and how we get around, but existing research has not examined whether they are being designed to promote healthy choices. This study assesses the health impact of two products, Snapchat and Uber, through the lens of their companies’ environmental, social, and governance (ESG) goals in the context of the COVID-19 pandemic.
Methods: We use an exploratory multiple case design to present how health might be considered as a growth strategy for consumer technology products. Using publicly available material, we analyze the strengths, weaknesses, and opportunities for the products’ design, policy, and implementation to promote health.
Results: This distinct approach to health impact assessment successfully revealed existing organizational beliefs and practices with health impact. Snapchat’s social media platform fosters social interaction but lacks responsible design features, while Uber’s mobility platform has safety and privacy measures but lacks focus on physical activities as forms of mobility.
Conclusions: By using these products, positive health impact is possible: whether through social connection and information access (Snapchat), or increased mobility and physical activity (Uber). This case study highlights the untapped potential of intentionally designing products to influence health behaviors and promote health, especially through new uses of existing features. Leveraging external partnerships and subject matter experts will be crucial for success, but companies that choose to do so and embrace a health-positive mindset will lay a foundation for a replicable business strategy for those too reticent to lead in this nascent field.
Maîtriser le lexique des émotions à travers la métaphore. Une démarche socio-affective et socio-cognitive dans la construction de la compétence rédactionnelle à l’université
Authors: Kopeć Joanna
Published: November 2023

Cette contribution est centrée sur l’enseignement-apprentissage du lexique émotionnel lié aux concepts de solitude et de silence, en vue du développement de la compétence rédactionnelle en français langue étrangère au niveau avancé (B2). L’auteure applique la théorie de la métaphore conceptuelle de Lakoff et Johnson (1980) à l’enseignement-apprentissage du lexique émotionnel sémantiquement imprédictible, mais métaphoriquement motivé. L’article présente le déroulement et les résultats d’une courte expérimentation didactique menée au sein d’un groupe d’étudiants de licence en philologie romane. L’expérimentation questionne l’efficacité de l’approche socio-affective et socio-cognitive qui a eu pour but non seulement le développement des compétences lexicales, rédactionnelles et créatives mais aussi le tissage de liens affectifs entre les étudiants eux-mêmes, et entre l’enseignante et les étudiants durant le confinement dû au COVID-19 et l’enseignement-apprentissage en ligne. L’auteure propose un parcours didactique autour d’activités réflexives et celles d’écriture créative, intégrant respectivement le lexique émotionnel. L’expérimentation a démontré que le fait d’être conscient de la motivation métaphorique des expressions idiomatiques relatives aux émotions permet aux apprenants de mieux mémoriser, utiliser et organiser le lexique étudié ainsi que d’être plus créatifs. Malgré les avantages incontestables de l’approche présentée, son potentiel didactique devrait être testé à long terme et avec un plus grand nombre d’apprenants.
The Meaning of DEI for Persons with IDD
Authors: Kauffman James M , Polloway Edward A , Hallahan Daniel P
Published: November 2023

Diversity, equity, and inclusion (DEI) collectively provide a foundation for the fair treatment and active participation in society for persons with intellectual and developmental disabilities (IDD). Diversity recognizes the unique qualities and characteristics of individuals with IDD and acknowledges their strengths and talents as well as their weaknesses, differences, and unique needs. Equity focuses on the provision of equal access to opportunities and life experiences for individuals with IDD. Inclusion emphasizes the active engagement of students and adults with IDD in school and community, respectively.
Carta ao Editor sobre a Identificação de Medicamentos Potencialmente Inapropriados entre Idosos em Ambulatório em Portugal
Authors: Prazeres Filipe
Published: November 2023

N/a.
Transforming Healthcare: Prioritizing Psychological Trauma through Trauma-Informed Care
Authors: Cunha Catarina
Published: November 2023

N/a.
Determining the appropriate resting energy expenditure requirement for severe trauma patients using indirect calorimetry in Korea: a retrospective observational study
Authors: Lee Hak-Jae , Ahn Sung-Bak , Lee Jung Hyun , Kim Ji-Yeon , Yoo Sungyeon , Hong Suk-Kyung
Published: November 2023

Purpose: This study aimed to compare the resting energy expenditure (REE) measured using indirect calorimetry with that estimated using predictive equations in severe trauma patients to determine the appropriate caloric requirements.Methods: Patients admitted to the surgical intensive care unit between January 2020 and March 2023 were included in this study. Indirect calorimetry was used to measure the patients’ REE values. These values were subsequently compared with those estimated using predictive equations: the weight-based equation (rule of thumb, 25 kcal/kg/day), Harris-Benedict, Ireton-Jones, and the 2003 Penn State equations.Results: A total of 27 severe trauma patients were included in this study, and 47 indirect calorimetric measurements were conducted. The weight-based equation (mean difference [MD], –28.96±303.58 kcal) and the 2003 Penn State equation (MD, –3.56±270.39 kcal) showed the closest results to REE measured by indirect calorimetry. However, the REE values estimated using the Harris-Benedict equation (MD, 156.64±276.54 kcal) and Ireton-Jones equation (MD, 250.87±332.54 kcal) displayed significant differences from those measured using indirect calorimetry. The concordance rate, which the predictive REE differs from the measured REE value within 10%, was up to 36.2%.Conclusions: The REE values estimated using predictive equations exhibited substantial differences from those measured via indirect calorimetry. Therefore, it is necessary to measure the REE value through indirect calorimetry in severe trauma patients.
УКРАЇНА ЯК ГЛОБАЛЬНИЙ ГРАВЕЦЬ У СВІТОВІЙ ЕКОНОМІЦІ В ТРЕТЬОМУ ДЕСЯТИЛІТТІ ХХІ СТОЛІТТЯ
Authors: Войтко С.В.
Published: November 2023

Метою дослідження є виявлення перспектив розвитку національної економіки та трансформації інфраструктури України у післявоєнній відбудові на основі вивчення ресурсної бази, інтелектуального потенціалу та бачення фахівцями інших країн розвитку нашої країни. Методика дослідження – критичний аналіз стану та перспектив розвитку елементів соціально-економічної системи засобами рейтингування, компаративного аналізу та логічних суджень. Доведено високий ресурсний потенціал України. Виявлено суттєвий вплив економічної системи країни на фондовий ринок, на ринки енергоносіїв, продовольства та добрив. Російсько-українська війна призвела до зниження рівня світового ВВП на 1,0 % та зростання до 3,0 % глобальної інфляції у 2022 році. Практична значущість результатів полягає у можливості розвитку національної економіки України на основі наявної ресурсної бази з врахуванням інтелектуального потенціалу з метою підняття суб’єктності країни на рівень глобального гравця і успішної інтеграції до когорти країн з розвиненими соціально-економічними системами.
ТЕХНОЛОГІЇ ІНДУСТРІЇ 4:0 У ЦИФРОВІЙ ПАРАДИГМІ РОЗВИТКУ ГЛОБАЛЬНОЇ ЕКОНОМІКИ
Authors: Петько С.М.
Published: November 2023

Стаття присвячена дослідженню технологій Індустрії 4:0 у цифровій парадигмі розвитку глобальної економіки. Для досягнення поставленої мети автором були використані такі методи дослідження, як-от: метод компаративного аналізу, наукової абстракції та аналітичного методу. Проведено комплексне дослідження технологічного прогресу цивілізації; визначено основні технології Індустрії 4:0 та їх взаємозв’язок з цифровою економікою; презентовано корпорації-лідери технологічного та інноваційно-цифрового бізнесу з вартісним виміром ринку передових технологій; проаналізовано урядову програму Республіки Корея «I-KOREA 4:0» у цифровій парадигмі економічного розвитку країни з виокремленням 10 основних галузей та 5 сервісів. Доведено, що завдяки бурхливого розвитку ІКТ, основними бенефіціарами від технологічного прогресу стали технологічні та ІТ-корпорації «передових» технологій Індустрії 4:0. Визначено, що беззаперечними лідерами у глобальному цифровому бізнес-середовищі стали США та Китай. Значущість результатів дослідження полягають у практичному дослідженні реалізації урядової програми «I-KOREA 4:0» в Республіці Корея, що забезпечить країні довгострокове економічне зростання та конкурентне лідерство на глобальному ринку «передових» технологій. Беручи до уваги досвід Республіки Корея, а саме: створення гіперконективної smart-інфраструктури та національної НДДКР системи на основі технологій Індустрії 4:0, зможе підвищити якість життя українського населення та конкурентоспроможність вітчизняних виробництв шляхом використання технології 5G у процесі побудови післявоєнної інноваційно-цифрової екосистеми.
РОЗКРИТТЯ СУТНОСТІ ПОНЯТТЯ МІЖНАРОДНОЇ КОНКУРЕНТОСПРОМОЖНОСТІ ЕНЕРГЕТИКИ В УМОВАХ НЕВИЗНАЧЕНОСТІ
Authors: Зробок О.О. , Гавриш О.А.
Published: November 2023

Метою дослідження є розкриття сутності поняття міжнародної конкурентоспроможності енергетики в умовах невизначеності. Методи дослідження: декомпозиція, системний аналіз, морфемно-семантичний аналіз, етимологічний аналіз, порівняльний аналіз, метод логічного ланцюжка, групування, синтез, абстракція, теоретичне узагальнення. Результати дослідження: проведено декомпозицію поняття міжнародної конкурентоспроможності енергетики в умовах невизначеності на прості однослівні поняття; здійснено їх морфемно-семантичний та етимологічний аналіз; побудовано логічний ланцюжок між ними; проаналізовано структуру енергетики за об’єктами конкурентоспроможності. Практична значущість результатів дослідження полягає у тому, що на основі розкриття сутності міжнародної конкурентоспроможності енергетики в умовах невизначеності було надано рекомендації щодо кількісного оцінювання її рівня.
РОЛЬ КОНТЕНТ МАРКЕТИНГУ В РАМКАХ INBOUND МАРКЕТИНГУ
Authors: Дергачова В.В. , Григорова З.В.
Published: November 2023

Стаття розглядає концепції "outbound" і "inbound" маркетингу, зосереджуючись на контент-маркетингу як складовій "inbound" стратегії. Виокремлюються недоліки «outbound» маркетингу, такі як високі витрати і низька ефективність, що виникають через неселективний підхід до аудиторії. Відзначається, що натомість «іnbound» маркетинг та контент-маркетинг спрямовані на залучення потенційних клієнтів шляхом надання корисного та цінного контенту, що спонукає їх до дій. В статті також розглядається визначення контент-маркетингу та його відмінності від «inbound» маркетингу. Підкреслюється, що контент-маркетинг повинен бути спрямований на задоволення потреб споживачів, але при цьому також служити і цілям бізнесу. Зазначається, що «inbound» маркетинг включає більш широкий спектр інструментів та методів, порівняно з контент-маркетингом. Розглядаються різниця в спрямованості та змісті між двома підходами, а також поле діяльності кожного з них. Доводиться, що контент маркетинг та inbound маркетинг не синонімами, оскільки inbound маркетинг є більш широкою категорією.
АНАЛІЗ ІНВЕСТИЦІЙНОЇ ПРИВАБЛИВОСТІ АЛЬТЕРНАТИВНОЇ ЕНЕРГЕТИКИ УКРАЇНИ
Authors: Підлісна О.А. , Чепіжко Л.М.
Published: November 2023

Енергосистема України потребує відновлювальної модернізації. Виконаний аналіз інвестиційної привабливості альтернативної енергетики України за джерелами генерації, визначено підходи до формування дорожніх карт залучення інвестицій з позиції їх прибутковості і ефективності. В роботі візуалізовано вартісні преференції для потенційних інвесторів. Залучення приватних інвестицій спирається на державні гарантії економії витрат і обумовлено співставленням інвестиційної дохідності в енергосистемах країн Євросоюзу. Навантаження соціально-відповідального інвестування здійснюється через інституціональні структури ЄС, але за наявності ґрунтовного огляду альтернативної енергетики і дорожніх карт за окремими напрямами і територіями інвестпроєктів. Виконане дослідження систематизує напрями залучення іноземних інвестицій в альтернативну енергетику України з позиції самої України.
Function of people with spinal cord and health care models in high-complexity institutions in Colombia
Authors: Lugo Luz Helena , Grisales Maria Paz , Seijas Vanessa , Posada Ana Maria
Published: November 2023

Background: In Colombia, there are two reasons why the function profile of people with spinal cord injuries differs from the rest of the world: most injuries are related to violence with firearms, and there are no inpatient acute and subacute rehabilitation centers. Due to these differences, there is a need to describe the healthcare models of different institutions and how they affect the function of people with spinal cord injuries in Colombia.
Methods: Within the second International Spinal Cord Injury Community Survey (InSCI), we designed a national module to describe the different institutional healthcare models for spinal cord injury. It seeks to establish professionals involved in care, group dynamics, and rehabilitation objectives and intensity. Institutional coordinators of spinal cord care will complete the questionnaire.
Results: We expect that the InSCI and this module for institutional health care models will allow us to describe these models and how they affect the function of people with spinal cord injuries.
Neural inhibition as implemented by an actor-critic model involves the human dorsal striatum and ventral tegmental area
Authors: Castelo-Branco Miguel , Araujo Ana , Duarte Catarina , Sousa Teresa , Oliveira Joana , Pereira Ana , Macedo Antonio
Published: November 2023

Inhibition is implicated across virtually all human experiences. As a trade-off of being very efficient, inhibition is also prone to many errors. Rodent and computational studies show that midbrain regions play crucial roles during errors by sending dopaminergic learning signals to the basal ganglia for behavioural adjustment. However, the parallels between animal and human neural anatomy and function are not determined. We scanned human adults while they performed an fMRI inhibitory task requiring trial-and-error learning. Guided by the actor-critic model, our results implicate the dorsal striatum and the ventral tegmental area as the actor and the critic, respectively. Using a multilevel and dimensional approach, we also demonstrate a link between midbrain and striatum circuit activity, inhibitory performance, and self-reported autistic and obsessive-compulsive subclinical traits.
Genome-wide analysis of the KNOX gene family in Moso bamboo: Insights into their role in promoting the rapid shoot growth
Authors: Jiao Yang , Tan Jiaqi , Guo Hui , Huang Bin , Ying Yeqing , Ramakrishnan Muthusamy , Zhang Zhijun
Published: November 2023

Background
KNOTTED1-like homeobox (KNOX) genes, plant-specific homologous box transcription factors (TFs), play a central role in regulating plant growth, development, organ formation, and response to biotic and abiotic stresses. However, a comprehensive genome-wide identification of the KNOX genes in Moso bamboo (Phyllostachys edulis), the fastest growing plant, has not yet been conducted, and the specific biological functions of this family remain unknown.
Results
The expression profiles of 24 KNOX genes, divided into two subfamilies, were determined by integrating Moso bamboo genome and its transcriptional data. The KNOX gene promoters were found to contain several light and stress-related cis-acting elements. Synteny analysis revealed stronger similarity with rice KNOX genes than with Arabidopsis KNOX genes. Additionally, several conserved structural domains and motifs were identified in the KNOX proteins. The expansion of the KNOX gene family was primarily regulated by tandem duplications. Furthermore, the KNOX genes were responsive to NAA and GA hormones, exhibiting distinct temporal expression patterns in four different organs of Moso bamboo. Short Time-series Expression Miner (STEM) analysis and quantitative PCR (qPCR) assays demonstrated that PeKNOX genes may play a role in promoting rapid shoot growth. Additionally, Gene Ontology (GO) and Protein-Protein Interaction (PPI) network enrichment analyses revealed several functional annotations for PeKNOXs. By regulating downstream target genes, PeKNOXs are involved in the synthesis of AUX /IAA, ultimately affecting cell division and elongation.
Conclusions
In the present study, we identified and characterized a total of 24 KNOX genes in Moso bamboo and investigated their physiological properties and conserved structural domains. To understand their functional roles, we conducted an analysis of gene expression profiles using STEM and RNA-seq data. This analysis successfully revealed regulatory networks involving both upstream and downstream genes of KNOX. Furthermore, KNOX genes are involved in the AUX/IAA metabolic pathway, which accelerates shoot growth by influencing downstream target genes. These results provide a theoretical foundation for studying the molecular mechanisms underlying the rapid growth and establish the groundwork for future research into the functions and transcriptional regulatory networks of the KNOX gene family.
BCASE-SHC: Blockchain-based Certificateless Authenticated Asymmetric Searchable Encryption for Smart HealthCare
Authors: Arabnouri Arian , Shafieinejad Alireza
Published: November 2023

Nowadays, data has become the cornerstone of any organization's assets. However, this poses significant challenges for organizations, including the production, management, transfer and protection of data. To overcome these challenges, many organizations have adopted information outsourcing and resource sharing, with cloud computing that is the most popular outsourcing technology. Cloud computing offers various attractive features such as data availability, elasticity, and ubiquitous computation. However, the utilize cloud computing also introduces confidentiality and privacy concerns. One solution to address this problem is encryption. However, traditional encryption prevents selection of desired documents, which is crucial in big data scenarios. To enable search capability, researchers introduced searchable encryption which has drawbacks such as keyword guessing attacks, malicious service providers, lack of trust, data integrity, and fairness. In this paper, we propose a solution that leverages blockchain technology to data integrity and data availability insurance, fair payment, and establish trust among the involved parties. Additionally, we present a certificate-less authenticated asymmetric searchable encryption scheme to address challenges such as data owner and receiver identity and keyword guessing attacks. This scheme is implemented using a smart contract, and we have evaluated its efficiency and proved it is operational.
Music matters – A qualitative evaluation of a nurse-led structured, group-based music program complementary to early intervention for service users with first-episode psychosis
Authors: Abild Signe Marie , Schuster Sofie , Midtgaard Julie
Published: November 2023

Background: Schizophrenia is a severe mental illness that has lasting negative impact on functional level, and quality of life. While music therapy has shown promise in improving these areas, there is a lack of research exploring the impact of music programs led by mental health care professionals without formal music therapy training in the context of early intervention in psychosis. This study aimed to conduct a qualitative evaluation of a once weekly, 12-week, nurse-led music group, in the constellation of a band, offered as an adjunct to early intervention in young people with first-episode psychosis. The specific objectives were to explore social interaction and experiences of participants and instructors in relation to the music group and provide focus points for implementation in clinical practice.
Method: The study utilized Interpretive Description, collecting data through participant observation (6 sessions x 1.5 hrs; 9 hrs in total), key informant interviews (n=1), and group (n=4) and email-based (n=2) interviews. The data was transcribed, thematized, and analyzed using NVivo12 and Interpretive Description inductive analysis.
Results: The analysis resulted in three main themes: Practicalities of the music program, Restored identity, and Music as medicine reflecting the potential of the music group to contribute to a sense of non-patient identity, decreasing symptoms related to mental illness, foster social relationships and a feeling of belonging to a musical community.
Conclusion: Participation in music groups can be a possible promoter of recovery. However, sustainability appears contingent on the skills and resources of the facilitator (i.e. nurse). Suggestions for a program theory and clinical implications are presented and discussed.
Trial registration: This is a non-experimental study, and according to Danish law, registration is not required.
Direct, Maternal and Heterotic Effects for Production Traits of a Two Breed Diallel Between Holstein and Brown Swiss Under Subtropical Conditions
Authors: Robles René C Calderón , Rodríguez Anel Ledesma , Utrera Ángel Ríos , Bermúdez Moisés Montaño , Velázquez Guillermo Martínez , Vega-Murillo Vicente E.
Published: November 2023

The present study aimed to estimate direct, maternal and heterotic effects for production traits of a two-breed diallel between Holstein and Brown Swiss under subtropical conditions. The study was carried out with information collected at the Las Margaritas experimental site, belonging to the National Institute of Forestry, Agriculture, and Livestock Research. Productive and genealogical information from cows belonging to the genetic groups Holstein (HO; 64), Brown Swiss (BS; 91), and their F1 reciprocal crosses HO/BS (29) and BS/HO (25) were used. The analyzed traits were: total milk yield per lactation (TMY, kg), lactation length (LL), milk yield per day (DMY; kg/d), milk yield per calving interval (IMY), and cow weight at calving (CW; kg). The MIXED procedure was used for data analysis. Models included the fixed effects of sire breed, dam breed, calving year, calving season, parity number and the interaction between sire breed and dam breed, except for the IMY analysis, which did not include the parity number. Contrasts were used to estimate individual heterosis and differences in direct and maternal genetic effects. The sire breed effect was only significant for LL (p < 0.05), while calving year was significant for TMY and IMY. Both calving season and parity number were significant for TMY, DMY, and CW. The sire breed * dam breed was significant for TMY, DMY and IMY. Heterosis was significant for TMY, DMY and IMY with values of 422.92 kg, 1.38 kg/d, and 1.48 kg/d, respectively. Direct and maternal genetic effects were only significant for LL.
Clinical Outcomes of liver transplantation in human immunodeficiency virus/hepatitis B virus coinfected patients in China
Authors: Tang Jianxin , Weng Ruihui , Fang Taishi , Zhang Kangjun , Yan Xu , Jin Xin , Xie Linjie , Zhao Dong
Published: November 2023

Background
Highly active antiretroviral therapy (HAART) has been able to improve the immune system function and survival of human immunodeficiency virus (HIV) patients. However, Patients coinfected with HIV and hepatitis B virus (HBV) are more likely to develop end-stage liver disease (ESLD) than those infected with HBV alone. Consequently, liver transplantation is often required for these patients. This study evaluates the outcomes of orthotopic liver transplantation (OLT) of HIV-HBV coinfected patients in China.
Methods
We conducted a retrospective analysis on all HIV-HBV coinfected patients that underwent OLT from April 1, 2019 to December 31, 2021 and their outcomes were compared to all HBV monoinfected patients undergoing OLT during the same period. Patient outcomes were determined, including cumulative survival, viral load, CD4 T-cell count and postoperative complications.
Results
The median follow-up of HIV recipients was 36 months after OLT (interquartile range 12–39 months). Almost all patients had stable CD4 T-cell count (> 200 copies/ul), undetectable HBV DNA levels, and undetectable HIV RNA load during follow-up. The 1-, 2-, and 3-year posttransplant survival rates were 85.7% for the HIV group (unchanged from 1 to 3 years) versus 82.2%, 81.2%, and 78.8% for the non-HIV group. Cumulative survival among HIV-HBV coinfected recipients was not significantly different from the HBV monoinfected recipients (log-rank test P = 0.692). The percentage of deaths attributed to infection was comparable between the HIV and non-HIV groups (14.3% vs. 9.32%, P = 0.665). Post OLT, there was no significant difference in acute rejection, cytomegalovirus infection, bacteremia, pulmonary infection, acute kidney injury, de novo tumor and vascular and biliary complications.
Conclusions
Liver transplantation in patients with HIV-HBV coinfection yields excellent outcomes in terms of intermediate- or long-term survival rate and low incidence of postoperative complications in China. These findings suggest that OLT is safe and feasible for HIV-HBV coinfected patients with ESLD.
Trial registration
Chinese Clinical Trial Registry (ChiCTR2300067631), registered 11 January 2023.
Blood and MRI biomarkers of mild Traumatic Brain Injury in non-concussed collegiate football players
Authors: Cho Eunhan , Granger Joshua , Bailey Theall , Nathan Lemoine , Calvert Derek , Marucci Jack , Mullenix Shelly , O'Neal Hollis , Jacome Tomas , Irving Brian , Johannsen Neil M. , Carmichael Owen , Spielmann Guillaume
Published: November 2023

Football has one of the highest incidence rates of mild traumatic brain injury (mTBI) among contact sports; however, the effects of repeated sub-concussive head impacts on brain structure and function remain under-studied. We assessed the association between biomarkers of mTBI and structural and functional MRI scans over an entire season among non-concussed NCAA Division I linemen and non-linemen. Concentrations of S100B, GFAP, BDNF, NFL, and NSE were assessed in 48 collegiate football players (32 linemen; 16 non-linemen) before the start of pre-season training (pre-camp), at the end of pre-season training (pre-season), and at the end of the competitive season (post-season). Changes in brain structure and function were assessed in a sub-sample of 17 players using structural and functional MRI during the execution of Stroop and attention network tasks. S100B, GFAP and BDNF concentrations were increased at post-season compared to pre-camp in linemen. White matter hyperintensities increased in linemen during pre-season camp training compared to pre-camp. This study showed that the effects of repeated head impacts are detectable in the blood of elite level non-concussed collegiate football players exposed to low-moderate impacts to the heads, which correlated with some neurological outcomes without translating to clinically-relevant changes in brain anatomy or function.
Event Generation and Consistence Test for Physics with Sliced Wasserstein Distance
Authors: Cai Hao , Pan Chu-Cheng , Xiang Dong , Sun Yu-chang , Cheng Ao-Yan , Wang Ao-Bo , Hu Yu-Xuan
Published: November 2023

In the field of modern high-energy physics research, there is a growing emphasis on utilizing deep learning techniques to optimize event simulation, thereby expanding the statistical sample size for more accurate physical analysis. Traditional simulation methods often encounter challenges when dealing with complex physical processes and high-dimensional data distributions, resulting in slow performance. To overcome these limitations, we propose a solution based on deep learning with the sliced Wasserstein distance as the loss function. Our method shows its ability on high precision and large-scale simulations, and demonstrates its effectiveness in handling complex physical processes. By employing an advanced transformer learning architecture, we initiate the learning process from a Monte Carlo sample, and generate high-dimensional data while preserving all original distribution features. The generated data samples have passed the consistence test, that is developed to calculate the confidence of the high-dimentional distributions of the generated data samples through permutation tests. This fast simulation strategy, enabled by deep learning, holds significant potential not only for increasing sample sizes and reducing statistical uncertainties but also for applications in numerical integration, which is crucial in partial wave analysis, high-precision sample checks, and other related fields. It opens up new possibilities for improving event simulation in high-energy physics research.
Effects of local vibration on waist circumference and central obesity in overweight women with sedentary lifestyle
Authors: Hashemi Bahar , Mazaheri Reza , Alizadeh Zahra , Guazzi Marco
Published: November 2023

Background: Vibration is a therapeutic modality that improves muscle function, increases energy expenditure, and consequently reduces body fat. Local Vibration on abdominal region may reduce waist circumference through increasing local blood flow and sustaining contractions of the abdominal muscles. This study aimed to investigate the effects of using vibrating belt on body composition parameters among overweight women with sedentary lifestyle.
Methods: This experimental clinical study was on 35 overweight women with sedentary lifestyle. During an eight-week intervention, the effects of using vibrating belt (three sessions a week for half an hour) were investigated. Body composition was assessed via measuring waist circumference, abdominal circumference, abdominal and supra-iliac skin folds alongside the variables of an electrical bio-impedance device.
Results: The mean age of participants was 37±6 years. The percentage of body fat, waist circumference, abdominal and supra-iliac skin folds were significantly decreased at the end of the study (P<0.05). Waist circumference also showed a significant decrease in the mid-point of the study, compared to the beginning (P<0.05). Abdominal skin fold also showed a significant decrease at the end of the study, compared with the mid-point (P<0.05). However, weight, BMI, Lean Body Mass, Soft Lean Mass and abdominal circumference did not change significantly (P>0.05).
Conclusion: The use of vibrating belt by sedentary overweight women may reduce the percent body fat, waist circumference, abdominal and supra-iliac skin folds without any side effect. This might implicate the effect of using vibrating belts in the management of central obesity by reducing abdominal subcutaneous fat.
Bidirectional two-sample Mendelian randomization analysis reveals a causal correlations of inflammatory cytokines on diabetic nephropathy risk
Authors: Song Siyuan , Yu Jiangyi
Published: November 2023

Objective:
The causal correlations of inflammatory cytokines on diabetic nephropathy risk was explored by Bidirectional two-sample Mendelian randomization analysis.
Method:
In this study, the data of diabetic nephropathy (DN) was extracted from the IEU OpenGWAS Project database, and the data on inflammatory cytokines was obtained from GWAS summary statistics from catalog database. The inverse variance weighted (IVW) is used as the main analysis method, and MR-Egger regression, weighted mode, and weighted median (WM) are used as supplementary methods to analyze the causal correlations of inflammatory cytokines on diabetic nephropathy risk. Cochran Q test and MR-Egger regression intercept are used for sensitivity analysis, and the P value is used as the index of results.
Result:
A total of 4 SNPs associated with inflammatory cytokines were screened as instrumental variables, IVW results showed a causal relationship between tumor necrosis factor ligand superfamily member 14 levels and TNF-related activation-induced cytokine levels and DN with a positive correlation, while Interleukin-1-alpha levels and Transforming growth factor-alpha levels had a causal relationship with DN with a negative correlation. The results of the ME-Egger intercept test were not multiplicative (P > 0.05), indicating that Mendelian randomization was a valid method for causal inference in this study. The results of reverse MR analysis showed that there was no causal relationship between DN and the increased risk of positively identified inflammatory cytokines.
Conclusion:
Tumor necrosis factor ligand superfamily member 14 levels and TNF-related activation-induced cytokine levels are independent risk factors for DN, while Interleukin-1-alpha levels and Transforming growth factor-alpha levels are independent protective factors for DN.
One equivalent mining height model for predicting the compression-consolidation-creep-diagenesis of compacted gangue backfill body——A case study on double wide-strip mining with gangue backfill
Authors: Xu Lei , Wang Siyu , Elmo Davide , Ding Shuxue , Zhu Hengzhong , Li Wenfeng , Chen Wen
Published: November 2023

Taking the double wide-strip mine gangue backfilling work face of 1101 and 1102 in the Tingnan Coal Mine as the background, this study utilizes theoretical analysis, numerical simulation, laboratory experiments, and engineering practices to investigate the complete process of compression-consolidation-creep-diagenesis of the compacted gangue backfill body, the equivalent mining height model, and the surface subsidence characteristics. The results: The maximum control roof distance in the gangue backfilling work face=Tip-to-face distance + Cutting depth + Roof beam length + Post-support gap. The advance subsidence amount of roof is equal to the maximum control roof distance multiplied by the sine value of the roof inclination angle. The height of available backfill space behind the support is equal to the mining height minus the roof advance subsidence, the unfilled height under roof, and the amount of floor heave behind the support. The compacted gangue body undergoes four stages of compression-consolidation-creep- diagenesis within the available filling height, with their respective compressibility rates as follows: skeleton adjustment stage (7.42%), slow compression stage (12.81%), consolidation settlement stage (13.15%), and creep diagenesis stage (25.53%). The equivalent mining heights corresponding to the four stages are 0.94m, 1.10m, 1.11m, and 1.48m, respectively. By comparing the predictions from probability integral method, numerical simulations, and subsidence observations, it is evident that the surface subsidence curves of the 1101 and 1102 working faces, along the strike main section, exhibit a "bowl" shape, with a gentle slope in the first two stages and a steep slope in the latter two stages. ht=Lmax×sinθ The subsidence curves of the 1101 and 1102 working faces, along the dip main section, show a "bowl" shape in the first two stages, and a "W" shape in the latter two stages.
Secured Healthcare Data Sharing Through Wireless Networks for Mobile Computing Using Trust-Bat-Adaptive Homomorphic Crypto Routing Protocol
Authors: Aljohani Abeer A. , Tripathi Rajendra Kumar , Bhardwaj Rajat , Kaushal Rajesh Kumar , Kumar Naveen , Gupta Shashi Kant , Hamato Gemechu Geda
Published: November 2023

The Wireless Sensor Network's (WSN's) sensor nodes commonly communicate via mobiles, which have been widely regarded as the most prevalent and perhaps most important communication technology. Due to their self-configuration, ease of handling, and adaptability, WSNs have become more popular in mobile computing. The WSN is set up with extra nodes to transport data. As a result of their short memory, poor throughput, restricted capacity, and other limitations, sensor networks become notoriously difficult to secure. WSN has been grappling with how to maintain network security in mobile computing while using as little power as possible in current history. So, we present a novel trust-bat-adaptive homomorphic crypto routing protocol (TBAHCRP) to overcome these difficulties. Initially, we gather healthcare datasets from the medical server and deploy a 5G (fifth-generation) network to transfer these datasets from sending node to receiving node. The encryption and decryption are performed by employing the proposed technique and it also performs clustering and routing functionalities. A multi-gradient spider monkey optimization (MG-SMO) approach is applied to optimize the received data for mobile applications. Finally, performance metrics like security level, memory usage, energy efficiency, and energy consumption of the proposed technique are examined and compared with other classical techniques to prove our work with the greatest efficiency. These metrics are depicted in graphical form by using the MATLAB tool.
Prevalence and Risk Factors of Helicobacter pylori Infection in children in Fuzhou, a High-Incidence Area for Gastric Cancer in Southeastern China
Authors: Chen Youtao , Pan Xiaoting , Wang Yanyan , Lin Longzhen , Chen Xiaoyan , Chen Yan , Ye Hong
Published: November 2023

Background
The burden of Helicobacter pylori infection remains high. Comprehensive data on the prevalence of H. pylori infection and associated risk factors in children remain scarce. The aim of this study was to investigate the prevalence of H. pylori infection and the risk factors for infection in a randomly selected population of children from a city in southeastern China.
Methods
A cross-sectional, randomized study of prevalence and risk factors was carried out among the children living in an urban community in southeastern China. A stratified random sampling method was first used to identify appropriate subjects. H. pylori infection was determined using the 13C-urea breath test. Risk factors were assessed using a structured interview schedule. Demographic information was collected on a standardized basis, and participants were given a questionnaire about their lifestyle choices, level of parental education and household size.
Results
In this survey, the sample population consisted of 338 children from 6–13 years old. The overall prevalence of H. pylori was 22.2% (75/338). The infection was most common for those aged 10–11 years. In this group 34.7% (33/95) of all children were positive for H. pylori, while in children aged 6–7 years 8.3% (4/48) were positive. In the multivariate logistic regression analysis, eat dessert or fried foods frequently and larger household size (≥ 4) were risk factors for H. pylori infection, higher family year income and frequency of household indoor cleaning were protective factors for H. pylori infection.
Conclusions
This study shows that children living in low socioeconomic status and poor sanitation become infected with H. pylori at an early age. The infection increased with age, eat dessert or fried foods frequently and domestic overcrowding. Further longitudinal studies must delve into the possible modes of transmission of this pathogen among young children.
Colistin Enhances Antimicrobial Activity against colistin-resistant Klebsiella pneumoniae by combined with the Chinese herbal crocin-1
Authors: Du Xin , Zhou Huijing , Wang Yue , Liu Yan , Huang Yali , Shi Shiyi , Xu Mengxin , Zhou Tieli , Zhou Beibei
Published: November 2023

Background Colistin (COL) is one of the last-line antibiotics of defense against multidrug-resistant (MDR) gram-negative bacteria However, colistin-resistant (Col-R) Klebsiella pneumoniae (K. pneumoniae) is increasing, which limits the clinical use of COL. Saffron is a traditional Chinese medicine with the effects of promoting blood circulation and removing blood stasis, relieving depression and calming the nerves, protecting the liver and promoting the gallbladder. Croin-1(CR) is an active ingredient extracted from saffron. In this study, we studied the antibacterial effects of CR and COL on Col-R K. pneumonia in vivo and in vitro.
Methods The checkerboard method and time-killing curve confirmed the synergistic antibacterial effect of CR combined with COL on Col-R K. pneumonia. The synergistic anti-biofilm and antibacterial activity were detected by crystal violet staining, scanning electron microscopy (SEM), and living cell fluorescent staining. The safety was assessed by the red blood cells (RBCs) hemolysis test, larval survival rates, and cytotoxicity test. The mice thigh infection model was established for in vivoexperiment. We determined the outer membrane permeability by measuring the uptake of fluorescent dye N-phenyl-1-naphthylamine(NPN) and propidium iodide (PI) staining. We further detected bacterial reactive oxygen species (ROS) production.
ResultsThe Results showed that compared with a single drug, the combination partially destroyed bacterial cells and inhibited the formation of bacterial biofilms. The CR/COL combination could decrease the number of bacteria after 24 h of therapy in the mouse thigh infection model. The CR/COL combination synergistically potentiated the antibacterial activity by accelerating the damage and permeability of the bacterial outer membrane. Erythrocytes hemolysis test showed that the hemolysis ability of CR was negligible. Therefore, CR has certain security.
Conclusions According to our results, CR can enhance the antibacterial effect of colistin against Col-R K. pneumonia, which may provide a feasible strategy for the fight against Col-R K. pneumonia.