bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of different levels of L-isoleucine in compound feeds on the growth of tilapia (Oreochromis niloticus)
Authors: Saleh H. , Hamwi M. N.
Published: October 2024

Four diets were developed, including the control (main diet), which actually contained 34.00% crude protein, while the other three contained protein close to this value, taking into account the measurement error, and isoleucine in groups 2, 3 and 4, 4.9%, 8.51% and 12.12%, respectively. The study of the effect of L-isoleucine additives in compound feeds on the growth of tilapia (Oreochromis niloticus) showed that varying the concentration of this amino acid has a significant effect on fish growth rates. Adjusting dosages makes it possible to achieve more efficient use of feed in aquaculture conditions. It was found that when the amino acid isoleucine is introduced into the diet, feed conversion decreases by 0.64 points with an additional concentration of 1.42 g/kg of feed (4.9%), by 0.88 points with additional administration of isoleucine by 1.55 g/kg of feed (8.51%), by 0.76 points with an additional concentration of 1.68 g/kg of feed (12.12%). It was shown that the best group with the lowest feed conversion rate was the 3rd group, in which the amino acid isoleucine was introduced into the diet by 8.51% more than in other groups. The optimal level of isoleucine administration in tilapia feed is 1.55 g/kg of feed (8.51%). It was found that the ash content in the carcass of O. niloticus increased by 0.8%, fat — by 1% in muscles compared with the control.
The development of the bone system of young Bestuzhev breed and its crossbreeds with simmentals
Authors: Kosilov V. I. , Yuldashbaev Yu. A. , Nikonova E. A. , Rakhimzhanova I. A. , Sedykh T. A. , Kalyakina R. G. , Dolgaya M. N.
Published: October 2024

Relevance. As a result of morphological studies, materials were obtained characterizing the effect of genotype and castration of young cattle and the development of the bone system in the postnatal period of ontogenesis.

Methodology. For the purpose of conducting the experiment, groups of experimental young animals were selected:

Results. The influence of the genotype and castration of young cattle on the absolute weight and length of individual parts and the entire skeleton of gobies and castrated gobies of the Bestuzhev breed and its first-generation crossbreeds with simmentals was established. The advantage of crossbred bulls of the ½ Bestuzhevskaya × ½ simmental group II in terms of the absolute weight of both the axial and peripheral skeleton over purebred and crossbred bulls and castrated bulls of the Bestuzhevskaya breed, crossbred castrated bulls has been established. For the entire mass of the carcass skeleton, this superiority was, respectively, 12 g (2.4%), 6616 g (14.7%) and 5553 (12.0%). Similar intergroup differences were found in the length of individual parts and the entire skeleton of the carcass.
Genetic architecture of meat traits in Large White sows
Authors: Trebunskikh E. A. , Belous A. A. , Otradnov P. I. , Conte A. F. , Reshetnikova A. A. , Volkova V. V. , Zinovieva N. A.
Published: October 2024

Currently, genome-wide association analysis is a modern and reliable method for analyzing genomic information about animals, as well as determining the “genotype — phenotype” relationship. This study aims to use the GWAS method to identify significant SNPs located within or linked to genes for meat traits in Large White pigs — backfat thickness over the 6–7th and 10–12th vertebrae, and loin muscle depth. The conducted GWA analysis revealed 60 genes, of which 17 are associated with biological functionality, annotated using the DAVID program. Three genes were found to have codification in the Pig QTL database. The genes were divided into 10 groups based on gene ontology (GO). Of all the genes, the AUTS2 gene, located on chromosome 3 and predicting the number of corpora lutea in sows, is of greatest interest. The results of this scientific work will contribute to the development of a genetic evaluation system and improvement of meat qualities in pigs.
Economic and biological assessment of a new medium-ripened variety of soft winter wheat Priazovye
Authors: Podgorny S. V. , Skripka O. V. , Samofalov A. P. , Chernova V. L. , Chernova A. A.
Published: October 2024

Relevance. In the Russian Federation, winter common wheat is the main food and strategic crop. Permanent improvement of productivity and quality of wheat grain, reducing its production costs is the main task of agricultural production. To solve this problem, the leading place is given to the continuous and constant creation and introduction into production of new competitive wheat varieties, highly adapted to stress factors, with guaranteed high yields and high grain quality.

Methods. The research was carried out in the southern zone of the Rostov region at the experimental sites of the Federal State Budgetary Scientific Institution ANTS “Donskoy” in 2021–2023 in order to create a new variety of soft winter wheat capable of forming not only high yields, but also having high frost resistance, drought resistance, resistance to leaf diseases, possessing high rheological and technological properties of grain and flour.

Results. The winter common wheat variety Priazovie was developed by stepwise hybridization using the varieties Voyazh and Tanya. This is a highly productive variety. On average, over three years (2021–2023) of study in the competitive variety testing, the productivity of the variety laid in green manure fallow was 9.88 t/ha, exceeding that of the standard variety by 1.56 t/ha. The variety is capable of producing high yields after various forecrops. The maximum productivity of the variety (12.23 t/ha) was obtained in green manure fallow in 2022. The variety forms a high stem capacity (up to 800 pcs/m²), and is characterized by high resistance to the main leaf diseases, such as powdery mildew, brown and yellow mildew, loose smut, leaf blotch, etc. According to the main indicators of grain and flour quality, it belongs to valuable wheat, in terms of frost resistance (73.3%) it surpasses the standard Ermak variety (69.2%).
Plagiocefalia posicional y neurodesarrollo: una revisión narrativa
Authors: Molinari Juan Martín , Molina Gabriela Luján , Muñoz-Serrano Noelia
Published: October 2024

La plagiocefalia posicional es una patología pediátrica frecuente. Se la ha considerado una condición estética, pero recientemente ha sido explorada su asociación con retraso en el neurodesarrollo.Objetivo: Actualizar los hallazgos de una revisión sistemática de 2017 acerca de plagiocefalia y neurodesarrollo mediante una revisión narrativa.Método: Se realizó el relevamiento de artículos en las bases MEDLINE, PubMed, Google Scholar y DeepDyve, la extracción de datos de los estudios más relevantes, y la evaluación de su calidad metodológica. Los términos de búsqueda utilizados fueron “plagiocephaly”, “positional plagiocephaly”, “brachycephaly”, “motor skills”, “development”, “developmental delay”, “neurodevelopment”, “language acquisition”, “psychomotor performance” y “cognition”.Resultados: La búsqueda recuperó 198 artículos, de los cuales 14 cumplieron los criterios de inclusión. Se relevan poblaciones infantiles entre los 4 – 7 meses y los 8 años. Las limitaciones incluyen sesgos de selección, uso de la misma población en varios estudios, y ausencia de uniformidad de diagnóstico. Los resultados muestran asociación positiva entre plagiocefalia y retraso en el neurodesarrollo. Los estudios con mayor calidad metodológica encuentran el retraso en diferentes momentos evolutivos (7, 18, y 36 meses, y edad escolar) y dimensiones (motora, cognitiva, conductual y lingüística).Conclusiones: Se observa asociación entre plagiocefalia y retraso en el neurodesarrollo. Los profesionales de la salud del primer nivel de atención deberían monitorear a los lactantes con esta condición, para implementar las intervenciones correspondientes.
Tratamiento prolongado del ductus arterioso persistente con paracetamol en recién nacidos prematuros de muy bajo peso
Authors: Cotua Silva Scarlet , Bancalari Molina Aldo , Sandoval Seguel Macarena
Published: October 2024

El Ductus arterioso persistente hemodinámicamente significativo (DAP-hs) en recién nacidos de muy bajo peso al nacer (RNMBPN) continúa siendo motivo de investigación respecto al momento de tratar y cuál sería el fármaco más adecuado.Objetivo: Evaluar el resultado del tratamiento prolongado con paracetamol en el cierre del ductus arterioso persistente hemodinámicamente significativo en recién nacidos prematuros.Pacientes y Método: Estudio retrospectivo, en RNMBPN con diagnóstico ecocardiográfico y clínico de DAP-hs que recibieron tratamiento con paracetamol endovenoso a 15mg/kg cada 6 horas durante 6 días. Al término del tratamiento se realizó ecocardiografía de control. Para la evaluación de posibles efectos secundarios se realizaron exámenes bioquímicos previo y posterior al tratamiento.Resultados: Se evaluaron 62 RNMBPN con peso y edad gestacional promedio ± DE 1.094 ± 257 g y 27,9 ± 2,1 semanas respectivamente. Al inicio del tratamiento, el tamaño ductal promedio ± DE fue de 2,2 ± 0,5 mm. La tasa de cierre ductal con el primer curso de tratamiento fue de 69,4% (43/62), y con el segundo curso aumentó a 87,1% (54/62). Requirieron cierre quirúrgico 9,7% de los neonatos (6/62). En los prematuros cuyo DAP-hs no cerró con el primer ciclo de paracetamol se observó un aumento en la incidencia de retinopatía del prematuro e injuria renal aguda. Los exámenes bioquímicos al término del tratamiento mostraron descenso significativo de la creatinina y ascenso del recuento plaquetario (p < 0,05).Conclusión: En RNMBPN con DAP-hs el tratamiento prolongado con paracetamol endovenoso no incrementa la tasa de cierre ductal respecto al tratamiento habitual de 3 días.
Más allá de las pausas de apnea en el prematuro: distrofia miotónica tipo 1 congénita
Authors: Del Olmo Segura Patricia , Solé Delgado Carolina , Martínez del Val Elena
Published: October 2024

La distrofia miotónica tipo 1 (DM1) congénita es una entidad poco frecuente que puede suponer un reto diagnóstico, especialmente si coexisten otros procesos como la prematuridad.Objetivo: Describir un caso clínico de presentación típica de DM1 congénita, y aumentar así la sospecha diagnóstica.Caso Clínico: Recién nacida pretérmino de 29 semanas que precisó ventilación mecánica no invasiva hasta la semana 41 de edad postmenstrual, presentando apneas que se manejaron con ventilación manual con bolsa autoinflable y masaje cardiaco. Inicialmente se atribuyeron a la prematuridad. Sin embargo, la paciente presentaba hipotonía, hiporreflexia, retracción aquílea bilateral, diplejía facial y succión débil, características que junto con el compromiso respiratorio, orientaban a una enfermedad neuromuscular. Como antecedentes destacaba infertilidad en la madre y polihidramnios durante la gestación. En la exploración dirigida a la madre presentaba miotonía clínica, confirmada posteriormente en el electromiograma, lo que orientó a una distrofia miotónica congénita. Se confirmó genéticamente encontrándose 2000 copias CTG en la recién nacida y 833 en su madre.Conclusiones: Las  apneas y compromiso respiratorio en un recién nacido hipotónico y débil son una manifestación frecuente de esta enfermedad. La presencia de miotonía en la madre de un recién nacido con sospecha de enfermedad neuromuscular orienta a DM1 congénita. Este caso destaca la importancia de la anamnesis y exploración exhaustiva a la paciente y su madre como elementos claves en la orientación diagnóstica etiológica.
Indicadores de Qualidade da Nutrição Enteral Domiciliar em Municípios de uma Regional de Saúde do Paraná: Estudo Transversal
Authors: Oliveira Vitória Maria Faria Rocha , Castilho Paula Hobi Weiss Cunha , Kauberg Rafaela Pachecho , Thieme Rubia Daniela , Schieferdecker Maria Eliana Madalozzo
Published: October 2024

A segurança do paciente é um dos atributos da qualidade do cuidado. O uso de protocolos é importante para a qualidade das ações em saúde. O objetivo foi avaliar os indicadores de qualidade da Nutrição Enteral Domiciliar em municípios de uma regional de saúde do Paraná. Estudo transversal, cobrindo corte cronológico de agosto de 2021 a agosto de 2022. Foram incluídos municípios da segunda regional de saúde (N=29), classificados em pequeno, médio e grande porte. O instrumento Indicadores de Qualidade da Nutrição Enteral Domiciliar foi aplicado a nutricionistas ou secretários de saúde. Foram obtidas informações de nove municípios, sendo cinco de grande, três de médio e um de pequeno porte. Cinco municípios apresentaram protocolos voltados à Nutrição Enteral Domiciliar. Nos nove municípios, há organização para fornecimento de fórmulas nutricionais industrializadas, mas os indicadores de Qualidade do Serviço e de Efetividade foram alcançados parcialmente, o que pode impactar na qualidade da Nutrição Enteral Domiciliar.
Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases
Authors: Aulanniam  , Rudijanto Achmad , Wijaya Andreas Budi
Published: October 2024

The development of immunological methods in the 1970s and 1980s led to the identification of thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) as key players in the onset of autoimmune thyroid diseases (AITD). TSHR is primarily associated with hyperthyroidism, while TPO is linked to hypothyroidism. Advances in understanding TPO and TSHR as biomarkers over recent decades have enhanced their clinical application. This review explores the molecular basis of TPO and TSHR as biomarkers, highlighting their importance in diagnosing AITD and their potential to guide effective therapeutic strategies. Additionally, it discusses the development of lateral flow assay (LFA) kits developed by the authors, which show promise as rapid and reliable diagnostic tools for AITD.
Tổng hợp tạp F và tạp G của aripiprazol
Authors: Nguyễn Anh Vũ , Tạ Công Minh Huy , Ngô Thị Thanh Diệp
Published: October 2024

Đặt vấn đề: Aripiprazol N-oxid (tạp F) và dehydro aripiprazol (tạp G) là hai tạp quá trình, đồng thời là tạp phân hủy của aripiprazol, một thuốc tương đối mới thuộc nhóm chống loạn thần thế hệ 1. Dược điển Mỹ 2024 quy định phải kiểm tra tạp F và tạp G trong cả nguyên liệu và thành phẩm aripiprazol. Hiện nay, trong ngân hàng chất đối chiếu tại Việt Nam vẫn chưa có các tạp chuẩn F và G, điều này gây khó khăn không nhỏ cho công tác kiểm nghiệm. Cho đến nay, trong nước cũng chưa có nghiên cứu nào công bố quy trình tổng hợp tạp F và tạp G, do đó việc nghiên cứu tổng hợp tạp F và tạp G có độ tinh khiết cao làm cơ sở để thiết lập chất đối chiếu của hai tạp chất này có nhiều ý nghĩa cho công tác kiểm tra đánh giá chất lượng nguyên liệu và chế phẩm chứa aripiprazol tại Việt Nam.

Mục tiêu: Tổng hợp tạp F và tạp G có độ tinh khiết cao đủ điều kiện thiết lập làm chất đối chiếu.

Đối tượng và phương pháp nghiên cứu: Tạp F và tạp G được tổng hợp bằng phản ứng oxy hóa và phản ứng dehydro hóa aripiprazol. Sản phẩm được tinh chế và được xác định cấu trúc bằng các phương pháp phổ nghiệm. Độ tinh khiết được xác định theo phương pháp chuẩn hóa diện tích pic bằng HPLC-PDA.

Kết quả: Tạp F và tạp G được tổng hợp với hiệu suất toàn quá trình 64,35% và 64,04%, độ tinh khiết sắc ký của cả 2 sản phẩm đều đạt trên 99%, đủ điều kiện để có thể thiết lập làm chất đối chiếu.

Kết luận: Tổng hợp thành công tạp F và tạp G có độ tinh khiết cao, đủ điều kiện thiết lập làm chất đối chiếu.

Từ khoá: aripiprazol N-oxid, dehydro aripiprazol
EFEKTIVITAS SELF MANAGEMENT TERHADAP KECANDUAN BERMAIN GADGET PADA ANAK USIA SEKOLAH
Authors: Simanjuntak Edriyani Yonlafado , Aryani Novita , Rahmadayanti Vita
Published: October 2024

Gadget merupakan hal yang sangat membantu anak dalam mengikuti perkembangan zaman, namun penggunaan gadget yang berlebihan akan mengakibatkan adanya kecanduan. Salah satu cara menurunkan kecanduan bermain gadget pada anak usia sekolah menggunakan teknik Self Management. Penelitian ini bertujuan untuk mengetahui efektivitas Self Management terhadap kecanduan bermain gadget pada anak usia sekolah di SD Negeri 0715 Pir Sosa IV dengan menggunakan pendekatan kuantitatif dengan Pre Experimen model one group pre-test post-test design. Populasi anak sekolah berjumlah 68 responden dan dilakukan screening yang kecanduan tinggi dan sedang sebanyak 60 orang dan diambil sampel untuk penelitian sebanyak 19 responden menggunakan Stratified Random Sampling. Alat pengumpulan data yang digunakan adalah kuesioner SAS. Pengolahan data dengan uji statistic Paired Sample Test dan hasil penelitian menunjukkan kecanduan bermain gadget menurun dengan p-value 0,00 (<0,05) atau ada perubahan yang signifikan sebelum dan sesudah diberikan Self Management. Kesimpulan penelitian ini adalah Self Management efektif terhadap kecanduan bermain gadget pada anak usia sekolah.
Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method
Authors: Pangaribowo Dian Agung , Fathunnisa Fathunnisa , Nugraha Ari Satia , Puspaningtyas Ayik Rosita , Sary Indah Purnama
Published: October 2024

Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid structure can be modified by changing the carboxylic -OH group into an amine group through an N-atom acylation reaction. This study was conducted by reacting cinnamoyl chloride (1a), which is a cinnamic acid derivative with 1,2,3,4-tetrahydroisoquinoline (2b) which is a compound of isoquinoline group to produce (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one (3b) and then tested for antioxidant activity using DPPH method. The resulting product compound was yellow crystals with a yield of 81.56%. The antioxidant activity produced by the product is more significant than that of cinnamic acid compounds at the same concentration.
Antioxidant Activity, Total Phenolics, and Total Flavonoids Content of Bajakah Tampala (Spatholobus littoralis): The Indigenous Herbal Medicine from Kalimantan
Authors: Mahfudh Nurkhasanah , Murdi Habib Basyanur , Utami Dwi , Ahda Mustofa , Nashihah Siti , Andika Andika
Published: October 2024

Bajakah tampala (Spatholobus littoralis), a medicinal plant traditionally used in Indonesia, particularly on Kalimantan Island, has garnered interest for its potential health benefits. However, scientific evidence remains scarce. This study investigated the antioxidant activity of S. littoralis extract and its total phenolic and flavonoid content. Ethanol extraction and evaporation were used to prepare the extract. The DPPH method assessed antioxidant activity, while Folin–Ciocalteu and AlCl3 complexation methods quantified total phenolics and flavonoids, respectively. The S. littoralis extract exhibited strong antioxidant activity with an IC50 value of 54.19 ± 8.15 µg/mL. Additionally, the extract contained substantial levels of phenolics (0.649 ± 0.026% GAE) and flavonoids (1.084 ± 0.043% QE). These findings suggest a link between the high phenolic and flavonoid content of S. littoralis extract and its observed strong antioxidant activity.
Pre-Post Survey Analysis on Pharmacy Students' Perceptions of Pharmacist Roles in the Pharmaceutical Industry
Authors: Adina Anugerah Budipratama , Yuwanda Alhara , Budiastuti Rizky Farmasita , Nopratilova Nopratilova , Yusuf Eddy , Tan Suk Fei , Mawazi Saeid Mezail , Herli Amelia
Published: October 2024

The pharmaceutical industry is undergoing rapid evolution, characterized by a complex regulatory landscape and the need for diverse skill sets. This study aimed to assess pharmacy students’ perceptions of the pharmaceutical industry and the impact of a dedicated seminar on their career aspirations and knowledge. A pre-post online survey was administered to 55 undergraduate pharmacy students at the National Pharmacy Seminar 2024, hosted by Jakarta Global University. Data were analyzed using descriptive statistics and the Wilcoxon signed-rank test (p ≤0.05). Results indicate a strong preference for careers in state-owned pharmaceutical companies (63.6%) and research and development departments (34%). The seminar significantly enhanced participants’ understanding of pharmacists’ roles, industry complexities, drug development challenges, and regulatory requirements. Notably, 93% of participants reported that the seminar met their expectations and provided valuable insights for future career exploration. These findings underscore the importance of educational interventions in shaping pharmacy students’ career trajectories and aligning their knowledge with the dynamic pharmaceutical industry.
Integrative Network Pharmacology Unveils Limonia acidissima as a Potential Natural Product for Targeting Cancer
Authors: Wahyuni Reni Sri , Muchlisin M. Artabah , Jamil Ahmad Shobrun , Astuti Engrid Juni , Rafikayanti Agustin
Published: October 2024

Cancer remains a formidable health challenge worldwide, with complex molecular mechanisms driving its initiation, progression, and therapeutic resistance. In this study, we employed bioinformatics analyses to elucidate the molecular underpinnings of cancer biology, focusing on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Our GO analysis revealed the enrichment of key biological processes such as protein phosphorylation, regulation of programmed cell death, and transmembrane receptor signaling pathways, underscoring the critical roles of signaling cascades and regulatory mechanisms in tumorigenesis. Similarly, molecular functions such as protein kinase activity and ATP binding were identified as significantly enriched, highlighting the importance of protein kinases and molecular interactions in cancer development and progression. The KEGG pathway analysis further delineated dysregulated signaling pathways associated with cancer, including the MAPK and PI3K-Akt signaling pathways, implicating these pathways as central regulators of cancer progression. These findings deepen our understanding of cancer biology and offer potential targets for therapeutic intervention. Integrating multi-omics data and systems biology approaches may provide deeper insights into the intricate networks underlying cancer pathogenesis, paving the way for developing more effective treatments for cancer patients.
Faktor-Faktor Yang Mempengaruhi Kesulitan Belajar Ekonomi Peserta Didik Di SMAN 1 Danau Sembuluh
Authors: Purtina Arna , Agustina Erika jesinta , Suyati Endang sri , Rozikin Ahmad Zainul
Published: October 2024

Penelitian ini bertujuan untuk : Mengetahui Faktor-faktor Yang Mempengaruhi Kesulitan Belajar Ekonomi Peserta Didik di SMAN 1 Danau Sembuluh. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif. Subjek dalam penelitian ini adalah 7 orang peserta didik dan 1 guru mata pelajaran Ekonomi. Jumlah subyek dalam penelitian ini adalah 8 orang. Teknik pengumpulan data dan analisis data dalam penelitian ini adalah observasi, wawancara dan dokumentasi. Hasil penelitian menunjukan bahwa: (1) Terdapat enam faktor internal penyebab kesulitan belajar Ekonomi yaitu faktor kesiapan peserta didik yang kurang saat mengikuti pembelajaran, faktor pengalaman masih banyak pesera didik yang kesulitan memahami materi yang dijelaskan, faktor kecerdasan saat guru memberikan soal masih ada peserta didik yang tidak bisa menjawab karena kurang konsentrasi dan tidak memperhatikan, faktor mental kurangnya semangat saat mengikuti pembelajaran, faktor minat dan bakat yang lemah dari peserta didik, dan faktor kebiasaan peserta didik saat yang bersantai dikantin dan peserta didik yang masih berada diluar kelas saat pembelajaran dimulai. (2) Terdapat dua faktor eksternal yang sangat mempengaruhi kesulitan belajar yaitu lingkungan masyarakat sebab teman bergaul dirumah juga mempengaruhi peserta didik, dan media pembelajaran yang digunakan oleh guru tidak terlalu bervariasi yang menyebabkan peserta didik bosan dan kurang bersemangat.
Penerapan Metode Kooperatif Face to Face Promotive Interaction Untuk Meningkatkan Pembelajaran Ilmu Pengetahuan Sosial di Sekolah Menengah Pertama Muhammadiyah Palangkaraya
Authors: Sahida Hanna Olivia , Nurbudiyani Iin , Purtina Arna
Published: October 2024

Penelitian ini bertujuan untuk: (1) mengetahui aktivitas pembelajaran IPS dikelas IX-A SMP Muhammadiyah Palangka Raya dengan model pembelajaran kooperatif Face to Face Promotive Interaction, (2) mengetahui peningkatan hasil belajar Ilmu Pengetahuan Sosial di kelas IX-A Sekolah Menengah Pertama Muhammadiyah Palangka Raya dengan model pembelajaran kooperatif Face to Face Promotive Interaction. Subjek penelitian ini adalah peserta didik kelas IX-A Sekolah Menengah Pertama Muhammadiyah Palangka Raya yang berjumlah 28 orang. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Teknik pengumpulan data yang digunakan yaitu observasi dan tes. Analisis data yang digunakan yaitu analisis kualitatif dan analisis kuantitatif. Hasil penelitian ini menunjukkan bahwa: Hasil belajar Ilmu Pengetahuan Sosial peserta didik kelas IX-A Sekolah Menengah Pertama Muhammadiyah Palangka Raya meningkat. Hasil belajar peserta didik pada pra tindakan memperoleh nilai rata-rata 67,88 dan hasil belajar peserta didik pada siklus I memperoleh nilai rata-rata 79,26 dengan presentase ketuntasan klasikal 85%.
Upaya Meningkatkan Hasil Belajar Matematika Menggunakan Model Pembelajaran Team Game Tournament (TGT) berbantuan Media Tiruan pada Peserta Didik Kelas II SDN Tahai Jaya 2
Authors: Maghfiratullah Maghfiratullah , Friska Friska , Sugiyanto Sugiyanto , Wahidah Wahidah , Haidawati Purna
Published: October 2024

Penelitian ini bertujuan: (1) meningkatkan hasil belajar Matematika materi pengukuran waktu dengan model pembelajaran Team Game Tournament (TGT), (2) mendeskripsikan aktivitas belajar Matematika peserta didik di kelas II SDN Tahai Jaya 2 dengan menggunakan model pembelajaran Team Game Tournament (TGT) berbantuan media tiruan. Metode penelitian yang digunakan peneliti adalah rancangan Penelitian Tindakan Kelas (PTK) dari Kemmis C Taggart yang berusaha memecahkan atau menjawab permasalahan yang dihadapi pada situasi sekarang. Dengan jumlah subjek penelitian 26 peserta didik, dengan 15 orang laki-laki dan 11 orang perempuan. Hasil penelitian menunjukkan bahwa: (1) aktivitas peserta didik kelas II SDN Tahai Jaya 2 pada siklus I rata-rata 2,9 dengan kriteria cukup baik, kemudian pada siklus II rata-rata 3,2 dengan kriteria baik, aktivitas peserta didik meningkat menjadi aktif dalam proses pembelajaran dengan penerapan model pembelajaran Team Game Tournament (TGT), (2) hasil belajar Matematika kelas II SDN Tahai Jaya 2 pada tes awal memperoleh nilai rata-rata 46 dengan ketuntasan klasikal 11,53%, pada siklus I diperoleh nilai rata-rata 67 dengan ketuntasan klasikal 46,15% dan pada siklus II diperoleh nilai rata-rata 78 dengan ketuntasan klasikal 88,46%. Kesimpulan dari penelitian ini adalah bahwa model pembelajaran Team Game Tournament (TGT) dapat meningkatkan aktivitas dan hasil belajar Matematika pada peserta didik kelas II SDN Tahai Jaya 2.
Gambaran Hasil Uji Sensitivitas Antibiotik Terhadap Bakteri Escherichia coli dengan Metode DISC dan Sumuran
Authors: Rahmah Windya Nazmatur , Ramdhani Fitria Hariati , Hidayani Al
Published: October 2024

Pemeriksaan resistensi antibiotik terhadap bakteri memiliki banyak metode dan teknik yang berbeda, yaitu metode difusi sumuran, metode difusi cakram disc, metode difusi silinder, metode dilusi, dan metode difusi dilusi. Banyaknya metode pemeriksaan uji daya hambat bakteri yang ada membuat orang menjadi banyak pertimbangan dalam melakukan hal tersebut. Tujuan dalam penelitain ini adalah untuk mengetahui gambaran hasil uji sensitivitas antibiotik terhadap bakteri Escherichia coli dengan metode disc dan sumuran. Penelitian ini dilakukan dengan metode difusi cakram disc dan metode difusi sumuran. Hasil pengukuran rata-rata zona hambat antibiotik terhapat bakteri Escherichia coli didapatkan zona hambat metode difusi sumuran 31.71 mm dan metode difusi cakram disc 31,39 mm. Rata-rata hasil pengukuran metode difusi sumuran lebih besar 0,32 mm dari metode difusi cakram disc dan hasil pengukuran zona hambat metode difusi sumuran dan difusi cakram disc adalah Susceptible atau efektivitas antibiotik kuat.
Analisis Pengaruh Faktor Meteorologi Terhadap Konsentrasi Gas SO2 dan NO2 dari Cerobong Ketel Pabrik Gula X
Authors: Fifianah Mareta , Amalia Aussie
Published: October 2024

The process of burning bagasse in a steam boiler produces pollutants in the form of exhaust gas emissions through the chimney, which can pollute air quality and harm health. The aim of this study is to determine the great influence of meteorological factors including exhaust gas temperature, air temperature, and flow speed in 4 areas of the boiler pipe that can affect the load of SO2 and NO2 gas pollutants through statistical data analysis. The ANOVA test used in this study was the ANOVA One Way test. The results of the study showed that there was a significant influence of the air temperature factor on SO2 in Boiler 4 / Cheng Chen with a value of F value 14,553 and a sig value of 0,032, as well as the influence that exists on the exhaust gas temperature factor and air temperature on NO2 in Stork Boiler 2 with an F value of 15,358 ; 17,889 and a sig value of 0.030 ; 0.024. The results of the analysis can be used as monitoring to evaluate the success rate and operational efficiency of the boiler under the management that has been carried out.
Analisis Perbandingan Arus Jenuh Pada Pendekat Terlindung Simpang Diponegoro-Pilau-Nenas Dengan Metode MKJI Dan Time Slice
Authors: Ndari Sona , Puspasari Nirwana , Akbar Reza Zulfikar
Published: October 2024

Over time the number of vehicles has increased due to improved urban conditions. This affects the emergence of problems in the Palangka Raya urban transportation system, which has an impact on the performance of the road network, especially the performance of signalized intersections. The purpose of this research is to calculate the value of saturation current (S) using the IHCM 1997. In order to analyze the saturation flow and road performance on the Diponegoro - Pilau - Nenas approach, Primary data and Secondary data are required, Primary data includes intersection geometric data and traffic volume in green hours. While secondary data includes location maps and population. In analyzing the comparison of saturated flow refers to the IHCM 1997 and the Time Slice method. The results of the comparison analysis of saturated flow with IHCM 1997 and Time Slice method on each approach A, B, C, and D respectively are 12.64%, 27.52%, 14.94%, and 36.94%. Also obtained the highest DS value using the saturated flow value of IHCM 1997 and Time Slice method is on St. Pilau which is respectively 1.09 included in the level of service F, and 0.93 included in the level of service E, then from the results of this analysis can be known by using the results of the calculation of saturated flow of Time Slice method there is an increase in the value of Level of Service (LOS).
Inovasi Pendidikan Melalui P5: Menguatkan Karakter Siswa dalam Kurikulum Merdeka
Authors: Purtina Arna , Zannah Fathul , Syarif Ahmad
Published: October 2024

Inovasi pendidikan menjadi kebutuhan mendesak dalam menghadapi tantangan globalisasi dan perubahan sosial yang pesat. Di Indonesia, Kurikulum Merdeka diperkenalkan sebagai upaya untuk memperkuat kualitas pendidikan dengan menekankan pada fleksibilitas pembelajaran dan penguatan karakter siswa. Salah satu elemen inti dalam Kurikulum Merdeka adalah Proyek Penguatan Profil Pelajar Pancasila (P5), yang dirancang untuk membentuk siswa yang memiliki karakter kuat, kreatif, kritis, dan mampu bekerja sama dalam keberagaman. Penelitian ini bertujuan untuk menganalisis peran P5 sebagai inovasi pendidikan dalam membangun karakter siswa yang sesuai dengan nilai-nilai Pancasila serta mengkaji tantangan dan peluang dalam implementasi P5, serta dampaknya terhadap pembentukan karakter siswa. Metode deskriptif kualitatif digunakan untuk menggali konsep-konsep terkait inovasi pendidikan melalui P5: menguatkan karakter siswa dalam kurikulum merdeka, dengan studi literatur sebagai teknik pengumpulan data. Hasil penelitian menunjukkan bahwa melalui P5, sebagai bagian dari Kurikulum Merdeka, dirancang untuk mengintegrasikan nilai-nilai Pancasila ke dalam proses pembelajaran melalui pendekatan proyek yang interaktif dan kontekstual. Meskipun memiliki potensi besar dalam membentuk karakter siswa, implementasi P5 dihadapkan pada berbagai tantangan, seperti keterbatasan sumber daya, kesiapan guru, dan resistensi terhadap perubahan. Namun, dukungan kebijakan pemerintah dan peluang untuk meningkatkan kolaborasi komunitas serta pemberdayaan siswa menawarkan jalan keluar yang dapat mengoptimalkan penerapan P5. Dampak P5 terhadap pembentukan karakter siswa terlihat signifikan, dengan peningkatan kesadaran sosial, penguatan identitas kebangsaan, dan pengembangan keterampilan hidup yang esensial. Penelitian ini menyimpulkan bahwa P5 memiliki potensi besar sebagai alat pendidikan yang efektif dalam membentuk generasi muda yang berkarakter kuat dan sesuai dengan nilai-nilai Pancasila, meskipun masih memerlukan upaya lebih lanjut untuk mengatasi tantangan-tantangan dalam implementasinya.
Principals’ Records-Keeping Practices and School Effectiveness in Ilorin Metropolis Secondary Schools
Authors: Olaifa Adeseko Sunday , Fagbola Simbiat Mojibola , Ayoku Oba Baba , Sagaya Abiodun Amudalatu , Hassan Solawat Ajibola , Abolarin Taibat Joke
Published: October 2024

The research focuses on the record-keeping practices of principals in public secondary schools in Ilorin metropolis, Kwara State, Nigeria. Two research questions and one research hypothesis were raised to guide the study. A descriptive survey research design was employed, allowing for self-reporting of information without manipulating variables. The sample included 121 principals and 155 vice principals from four Local Government Areas. The research instrument was a structured questionnaire, "Principals' Records Keeping Practices and School Effectiveness Questionnaire (PRMPSEQ)," developed from a literature review. The data was analysed using both descriptive and inferential statistics. The study found a positive correlation between these two aspects, indicating that effective records management is crucial for achieving high levels of school effectiveness. The study found a moderate level of effectiveness in principals' records-keeping practices, with areas for improvement identified in record retrieval, disposal, use and archiving. The Pearson Product Moment Correlation analysis reveals a significant positive correlation between principals' record-keeping practices and school effectiveness in public secondary schools in Ilorin metropolis, Kwara State, Nigeria. Overall, the findings provide valuable information for policymakers and school administrators in Ilorin metropolis, suggesting that enhancing records management practices could be a strategic approach towards improving school effectiveness and ultimately, the quality of education for students. The findings suggest that schools should prioritise continuous improvement in their records management systems, focusing on enhancing retrieval, disposal, utilisation, and archiving practices. Recommendations include enhancing records management training, implementing standardised systems, investing in technology and conducting regular audits.
Patterns of Parental and Peer Assistance in the Formation of Anti Bullying Behavior in Students at SMPK Citra Bangsa Mandiri Kupang
Authors: Sarah Semarlica , Tari Ezra , Saingo Yakobus Adi
Published: October 2024

The objective of this study is to identify and explain the patterns of parental and peer support in shaping anti-bullying behaviour among students at SMPK Citra Bangsa Mandiri Kupang.  Bullying is a persistent and repetitive form of aggressive behaviour characterised by an unequal power dynamic between the offender and the victim, with the intention of causing harm and exerting pressure on the victims. This study employs descriptive methodologies with a qualitative approach, utilising interview techniques. This buy is mostly aimed for the eighth grade children. The study involved a total of four participants, comprising two parents and two students. Interviews are systematically done to examine the influence of school programmes on the development of anti-bullying behaviour through observation.  The study findings indicate the existence of three distinct forms of parental support in shaping children' anti-bullying behaviour. The concept of Conscious Parenting is the deliberate and mindful approach of raising children, with a strong emphasis on attentive care and effective communication. Authoritative Parenting, the second style, is distinguished by parents who make fair requests and have high levels of responsiveness towards their children. Parents who have been given official permission not only have elevated standards for their children, but also provide them with the necessary resources and assistance to achieve success.
Demographic Factors and Truancy Behaviour among Secondary School Students in Ilorin Metropolis, Kwara State
Authors: Ehindero Elizabeth Ronke , Lasisi Adekola Kamil
Published: October 2024

Background: Contemporary secondary school students exhibit a wide range of social maladjustment behaviours, especially truancy. Given this, the present study looked into the Demographic Factors Influencing Truancy Behaviour among Secondary School Students in Ilorin Metropolis, Kwara State. Method: The study used descriptive survey design with a multi-stage sampling procedure which involved purposive, stratified, and simple random methods. The research involved a total of 400 participants. The "Truancy Behaviour Scale (TBS)", was adapted to gather pertinent data. The instrument underwent validation by five seasoned lecturers specializing in Guidance and Counseling Educational Management and Test and Measurement. To assess the instrument's reliability, the researcher utilised the test Split-half method, yielding a reliability coefficient of 0.74. Demographic data was analyzed with frequency counts and percentages, and the four hypotheses formulated were tested using t-test and Analysis of Variance (ANOVA) at a significance level of 0.05. The findings show that demographic variables of student, family and school contributed significantly to truancy behaviour. The four null hypotheses tested in this study indicate that there was a significant difference in the demographic factors contributing to truancy behaviour among secondary school students in Ilorin metropolis, Kwara State, based on gender and family type (t = 2.88, p <0.05); (t = 2.56, p <0.05). Nonetheless, no significant differences were found based on the respondents' age and religion.
Age and Psychological Well-being as Predictors of Male Child Parenting among Married Adults
Authors: Sanni Ramata Funsho , Lasisi Adekola Kamil , Ahmed Taiye Hassan
Published: October 2024

Age is a critical factor in parenting, as parenting styles and attitudes can vary significantly across different age groups. Psychological well-being encompasses an individual's emotional health, life satisfaction, and overall mental state. The study examined age and psychological well-being as predictors of Male Child Parenting among married adults in Kwara State. A descriptive survey was used. The study was conducted on 384 married adults in Kwara Central Senatorial District, Kwara State, using a self-designed questionnaire called "Age and Psychological Wellbeing as Predictors of Male Child Parenting Questionnaire (APWDMCPQ). The questionnaire was validated by experts and its reliability was established through pilot testing using the Split-half method. The results were correlated using Spearman-Brown Correlation Coefficient Statistics (PBCCS) with a reliability index of 0.76. The study used mean and standard deviation to present answers to research questions, and Analysis of Variance (ANOVA) statistics to test hypotheses at a 0.05 level of significance. The study show that there is a significant effect of age on male child parenting (F.cal.=25.60, p.<0.05). The study found that there is no significant effect of psychological well-being on male child parenting (F.cal.=3.34, p.>0.05). The study found that age significantly impacts male-child parenting, but parental psychological well-being doesn't significantly affect it. It recommended that married adults aged 25-35 and 36-45 should seek counselling to develop appropriate parenting skills. Additionally, they should be educated on coping mechanisms to withstand the pressure of parenting male children, improving their psychological well-being and enabling effective male child parenting.
MobiTest – A Software for Mobile-Based Testing
Authors: Zaveri Ayesha Anees , Mashood Ramsha , Faisal Nabiha , Parveen Misbah , Sami Naveera , Nazar Mobeen , Imtiaz Saba
Published: October 2024

MobiTest is an application that serves as a valuable tool in the fast-growing field of software testing. Efficiency is crucial in this industry, where testers, quality assurance teams, and others must meticulously test each application, avoiding the need to repeat the entire cycle to identify bugs. This application is a breeze thanks to its intuitive features and educational content. Thanks to continuous integration, testers can easily keep up with the fast-paced development cycle and start automating tasks as soon as the user interface development is completed. This saves valuable time and ensures a smoother and more efficient process. During the development of this application, a need arose for manual testing, which unfortunately resulted in the inefficient use of resources. MobiTest was designed to overcome these limitations by providing the ability to generate generic test scripts for any application as needed. It can efficiently and adaptively handle intricate tasks according to predefined parameters. This application thoroughly examines every possible detail, allowing the hacker to exploit the system.
دور القيادة الجديرة بالثقة في تعزيز السلوك الاستباقي لحكام كرة القدم الصالات في العراق
Authors: Asst. Lec. Safaa Suhail Muhammad  , Asst. Lec. Ahmed Ismail Abdel Hamid  , Asst. Lec. Hassan Muhammad Musa
Published: October 2024

تضمن البحث على المقدمة واهميته. وتكمن اهمية البحث في التعرف على دور القيادة الجديرة بالثقة  في تعزيز السلوك الاستباقي لحكام كرة القدم الصالات في العراق وان ما يميز القيادة الجديرة بالثقة ان قادتها واثقين بأنفسهم وتظهر اهميتها داخل ميدان اللعب ويعبر القائد عن ذاته من خلال قراراته الصحيحة والتي تنعكس ايجابا على سلوكه ، اذ تعزز القيادة الجديرة الشعور بالثقة والانتماء والالتزام تجاه المؤسسة والرضا الوظيفي وسلوك المواطنة التنظيمي والعمل الاخلاقي لدى حكام كرة القدم الصالات في العراق  وتبرز مشكلة البحث في السؤال التالي: هل للقيادة الجديرة بالثقة دور في تعزيز السلوك الاستباقي لحكام كرة القدم الصالات في العراق ؟ ويهدف البحث الى تطبيق استبانتي القيادة الجديرة بالثقة والسلوك الاستباقي على عينة التطبيق لإيجاد مدى اسهام القيادة الجديرة بالثقة في تعزيز السلوك الاستباقي لدى حكام كرة القدم الصالات في العراق. أذ تتكون استبانة القيادة الجديرة بالثقة للجنة الحكام من (20) عبارة موزعة على أربعة مجالات (الوعي الذاتي، المنظور الاخلاقي، المعالجة المتوازنة، شفافية العلاقات) لكل مجال خمسة عبارات، اما مقياس السلوك الاستباقي فتكون من (14) عبارة موزعة على أربعة مجالات (الوقاية من المشاكل، الابتكار الفردي، تحمل المسؤولية، السلوك الصوتي) وبواقع أربع عبارات لكل من مجالي للسلوك الصوتي والابتكار الفردي وثلاث عبارات لكل من مجالي تحمل المسؤولية والوقاية من المشاكل.
Reklam Yoluyla Tüketicilerin Satın Alma Davranışının Etkilenmesi Örneği Olarak Örtülü Reklamlar ve Bunların Hukuki Denetimi
Authors: Arat Ayşe , Şimşek Sedat
Published: October 2024

Reklamlar aracılığıyla doğru bilgilendirmenin yapılmaması, yanlış veya yanıltıcı bilgiler verilmesi tüketicinin, satın alma davranışını etkilemektedir. Bu sebeple geleneksel ya da sosyal medyada yayınlanan yanıltıcı veya herhangi bir şekilde tüketicinin zarar görmesine neden olan reklamlardan toplumun etkilenmesini engellemek için hukuk sistemi devreye girmektedir. Reklamın, hukuka ve ahlaka uygun, doğru ve dürüst olmasının yanında reklam olduğu anlaşılacak şekilde yapılması gerekmektedir. Reklam olduğu belirtilmeden yapılan tanıtım, örtülü reklam olarak isimlendirilir ve yasaklanmıştır. Hukukumuzda iletişim aracının türü fark etmeksizin sesle, yazı ile veya görsel olarak örtülü reklam yapılamayacağı açıkça düzenlenmiştir. Reklamlar konusunda ülkemizdeki hukuki düzenlemeler dağınık bir şekilde bulunmaktadır. Bu düzenlemelerde, reklamın tanımı, hangi ilkelere tabi olduğu, reklam belirlenen ilkelere uygun yapılmadığında bunun denetiminin ve yaptırımın ne olacağı ortaya konulmaktadır. Çalışmada öncelikle reklam konusunda genel bilgiler ve hukuki düzenlemelerdeki reklam tanımları verilmiş, reklamların denetimi konusunda genel bir değerlendirme yapıldıktan sonra örtülü reklamlar özelinde bu denetimin nasıl işlediği Reklam Kurulu kararları çerçevesinde incelenmiştir. Araştırmanın yöntemi Doküman Analizidir. Bu doğrultuda Reklam Kurulu kararları üzerinde bir değerlendirme yapılmıştır. Reklam Kurulu kararlarında sosyal medya mecralarında, gazetelerde veya TV yayınlarında örtülü reklam tespit edildiğinde, tüketiciye buna ilişkin açık ve anlaşılır bilgi verilmezse durdurma yaptırımının uygulandığı, özellikle reklamda yasaklı olan ürünler kullanılmışsa durdurmaya ek olarak para cezası verildiği görülmektedir.
LITERATURE REVIEW: KAJIAN EFEKTIVITAS PERKEMBANGAN VAKSIN VIRUS DENGUE MASA KINI
Authors: Aulia Tisa
Published: October 2024

Dengue fever is a disease caused by the dengue virus (DENV) which often becomes a problem for public health in the world with approximately 390 million cases of infection. The lack of specific antiviral therapy for DENV is a driving force for the development of a dengue vaccine as a strategy to fight the DENV virus. This review discusses the development of dengue vaccines and makes effectivity comparisons with dengue vaccines that have been developed such as Dengvaxia, TV003/TV005, and DENVax to know the current status of the development of these vaccines.
Keywords : Dengue fever, Dengue Virus, vaccines, development, effectivity
Clinical Outcomes of Endonasal Dacryocystorhinostomy with Canalicular Trephination in Canalicular Obstruction
Authors: Han Su Yeon , Oh Jae Hyun , Kim Sang Duck
Published: October 2024

Purpose: To investigate the surgical outcomes of endonasal dacryocystorhinostomy with canalicular trephination in patients with canalicular obstruction.Methods: We retrospectively analyzed the medical records of 37 eyes from 32 patients who were diagnosed with canalicular obstruction between May 2010 and July 2022 and underwent endonasal dacryocystorhinostomy with canalicular trephination to evaluate the success rate and complications.Results: In the total patient group, 81.1% achieved complete success in which epiphora completely disappeared, 13.5% had partial success in which epiphora remained but improved, and 5.4% experienced failure in which tearing persisted or worsened. Complications included one case of dacryocystorhinostomy bony opening granuloma and one case of dacryocystorhinostomy bony opening inflammation.Conclusions: Endonasal dacryocystorhinosomy with canalicular trephination is an effective method for treating canalicular obstruction, offering a high success rate and few complications. It can be considered before resorting to conjunctivodacryocystorhinostomy, which is a more conventional treatment.