bluuebunny/crossref_metadata_2025 huggingface dataset:
How to Manage Synchronous Endometrial and Ovarian Cancer Patients?
Authors: Shin Wonkyo , Park Sang-yoon , Kang Sokbom , Lim Myongcheol , Seo Sang-Soo
Published: December 2020

Purpose: We aimed to evaluate the prognosis in patients with synchronous endometrial and ovarian cancer (SEOC) by comparing the differences between double primary cancer (DPC) and metastatic cancer (MC). Methods: The medical records of 47 patients diagnosed synchronously with endometrial and ovarian cancer between January 2006 and December 2018 were retrospectively reviewed. Twenty-eight and 19 patients were diagnosed with DPC and MC, respectively. Demographics, recurrence-free survival (RFS), and 5-year overall survival (OS) were compared. The clinical factors affecting survival were evaluated using univariate and multivariate analyses.Results: The demographics were not different between both groups. Endometrioid histology and the International Federation of Gynecology and Obstetrics grade were higher in the MC group than in the DPC group (42.1% vs. 10.7 %; P=0.018, P=0.002, respectively). The ratio of post-operative adjuvant therapy was not different in both groups. Recurrence occurred in five patients with DPC and seven with MC. The difference in RFS was not significantly different (P=0.131) but the OS was different between both groups (P = 0.020). Histology and para-aortic lymph node metastasis were associated wtih RFS in univariate analysis, but no difference was found in multivariate analysis.Conclusions: Although DPC patients had longer OS, multivariate analysis did not identify any influential factors. Focus should be placed on defining the appropriate adjuvant treatment for high-risk patients, which will improve prognosis, rather than on discriminating between DPC and MC.
The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019
Authors: Huang Runzhi , Meng Tong , Zha Qiongfang , Cheng Kebin , Zhou Xin , Zheng Junhua , Zhang Dingyu , Liu Ruilin
Published: December 2020

Background

The coronavirus disease 2019 (COVID-19) has induced a worldwide pneumonia with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression of COVID-19 are not well known.
Objective

The aim of this study is to identify the candidate predictors of COVID-19 and investigate their underlying mechanism.
Methods

The retrospective study was conducted to identify the potential laboratory indicators with prognostic values of COVID-19 disease. Then, the prognostic nomogram was constructed to predict the overall survival of COVID-19 patients. Additionally, the scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of the most important prognostic indicators in lungs and peripherals, respectively.
Results

304 hospitalized adult COVID-19 patients in Wuhan Jinyintan Hospital were included in the retrospective study. CEA was the only laboratory indicator with significant difference in the univariate (P < 0.001) and multivariate analysis (P = 0.021). The scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of CEA in lungs and peripherals, respectively. The results revealed the potential roles of CEA were significantly distributed in Type II pneumocytes of BALF and developing neutrophils of PBMCs, participating in the progression of COVID-19 by regulating the cell-cell communication.
Conclusion

This study identifies the prognostic roles of CEA in COVID-19 patients and implies the potential roles of CEACAM8-CEACAM6 in the progression of COVID-19 by regulating the cell-cell communication of developing neutrophils and Type II pneumocyte.
Establishment of Routine Clinical Indicators-Based Nomograms for Predicting the Mortality in Patients with COVID-19
Authors: He Jialin , Song Caiping , Liu En , Liu Xi , Wu Hao , Lin Hui , Liu Yuliang , Li Qi , Xu Zhi , Ren XiaoBao , Zhang Cheng , Zhang Wenjing , Duan Wei , Tian Yongfeng , Li Ping , Hu Mingdong , Yang Shiming , Xu Yu
Published: December 2020

Background: The aim of the study was to establish and validate nomograms to predict the mortality risk of patients with COVID-19 using routine clinical indicators. Method: This retrospective study included a development cohort enrolled 2119 hospitalized COVID-19 patients and a validation cohort included 1504 COVID-19 patients. The demographics, clinical manifestations, vital signs and laboratory test results of the patients at admission and outcome of in-hospital death were recorded. The independent factors associated with death were identified by a forward stepwise multivariate logistic regression analysis and used to construct two prognostic nomograms. The models were then tested in an external dataset. Results: Nomogram 1 is a full model included nine factors identified in the multivariate logistic regression and nomogram 2 is built by selecting four factors from nine to perform as a reduced model. Nomogram 1 and nomogram 2 established showed better performance in discrimination and calibration than the MuLBSTA score in training. In validation, Nomogram 1 performed better than nomogram 2 for calibration. Conclusion: Nomograms we established performed better than the MuLBSTA score. We recommend the application of nomogram 1 in general hospital which provide robust prognostic performance but more cumbersome; nomogram 2 in mobile cabin hospitals which depend on less laboratory examinations and more convenient. Both nomograms can help clinicians in identifying patients at risk of death with routine clinical indicators at admission, which may reduce the overall mortality of COVID-19.
Queratocisto odontogênico agressivo: relato de caso
Authors: Barros Maylson Alves Nogueira , Teslenco Vitor Bruno , Marques Diogo Henrique Rodrigues , Cavalcanti Herbert de Abreu , Reis Guilherme Nucci , Pancini Everton Floriano
Published: December 2020

Introdução: O queratocisto odontogênico compreende uma lesão cística benigna, de origem dos restos da lamina dentaria ou células epiteliais adjacentes, com altas taxas de recorrência, crescimento rápido no sentido antero-posterior no interior do tecido ósseo medular. Objetivo: Este trabalho tem como objetivo descrever relato de caso de um queratocisto atípico. Relato de Caso: Paciente leucoderma, 17 anos, encaminhando ao serviço de Cirurgia e Traumatologia Bucomaxilofacial devido queixa de aumento de volume, dor, dormência do lábio inferior, mobilidade dentaria. Foi solicitado exame de imagem, uma tomografia de face, onde se evidenciou uma imagem hipodensa, osteolítica, envolvendo região mandibular. O paciente foi diagnostico com queratocisto odontogênico, sendo submetido a tratamento conservador da lesão. Conclusão: O tratamento escolhido foi individualizado e escolhido conforme o embasamento teórico encontrado, levando em consideração todas as complicações. O tratamento proposto foi efetivo até atual momento, e o paciente permanece em acompanhamento clinico e radiográfico, entretanto não indica cura da doença.

Descritores: Cistos Ósseos; Patologia Bucal; Mandíbula.

Referências

Neville BW, Damm DD, Alen CM, Bouquot JE. Patologia oral e maxilofacial. 4.ed. Rio de Janeiro: Elsevier; 2016.

Tenorio J, Arias P, Martínez-Glez V, Santos F, García-Miñaur S, Nevado J, Lapunzina P. Simpson-Golabi-Behmel syndrome types I and II. Orphanet J Rare Dis. 2014;9:138. 

Sánchez-Burgos R, González-Martín-Moro J, Pérez-Fernández E, Burgueño-García M. Clinical, radiological and therapeutic features of keratocystic odontogenic tumours: a study over a decade. J Clin Exp Dent. 2014;6(3):e259-64.

de Castro MS, Caixeta CA, de Carli ML, Ribeiro Júnior NV, Miyazawa M, Pereira AAC, Sperandio FF, Hanemann JAC. Conservative surgical treatments for nonsyndromic odontogenic keratocysts: a systematic review and meta-analysis. Clin Oral Investig. 2018;22(5):2089-2101.

Fidele NB, Yueyu Z, Zhao Y, Tianfu W, Liu J, Sun Y, Liu B. Recurrence of odontogenic keratocysts and possible prognostic factors: Review of 455 patients. Med Oral Patol Oral Cir Bucal. 2019;24(4):e491-e501.

Chrcanovic BR, Gomez RS. Recurrence probability for keratocystic odontogenic tumors: An analysis of 6427 cases. J Craniomaxillofac Surg. 2017 Feb;45(2):244-51.

Jalali E, Ferneini EM, Rengasamy K, Tadinada A. Squamous cell carcinoma arising within a maxillary odontogenic keratocyst: A rare occurrence. Imaging Sci Dent. 2017;47(2):135-40.
Effect of Carbonate to Phosphate Molar Ratios on the Physico-Chemical Properties of Carbonated Hydroxyapatite Nanopowder
Authors: Mohd Noor Muhammad Syazwan , Mohd Afandi Nur Nabilah Afja , Mohd Noor Ahmad-Fauzi , Baba Ismail Yanny Marliana
Published: December 2020

The aim of this study was to incorporate carbonate ions (CO3 2–) into the hydroxyapatite (HA) crystal structure followed by investigation on the effect of different carbonate to phosphate (CO3 2–/PO4 3–) ratios on the phase purity, crystal structure as well as CO3 2– content present in the apatite structure. CO3 2– substitution has been proposed to enhance the performance of HA-based material, particularly on the physico-chemical properties. Three different compositions of carbonated hydroxyapatite (CHA) powder with different CO3 2–/ PO4 3– ratios (namely, CHA 1:1, CHA 2:1 and CHA 4:1) were chemically synthesised by nanoemulsion method at 37°C and characterised for their physico-chemical properties. Results demonstrated that all as-synthesised powders formed single phase B-type CHA without any additional phases. Interestingly, an increasing amount of CO3 2– substituted into the apatite structure gives rise to the formation of CHA structure with a variation on their cell parameters and the degree of crystallinity. An increase in the CO3 2–/ PO4 3– ratio was also found to lead a higher amount of CO3 2– content present in the as-synthesised powder (in a range of 4 wt % to 10 wt %), which is comparable to the CO3 2– content found in the human bone mineral.
Cooperating for knowledge and innovation performance: the case of selected Central and Eastern European countries
Authors: Gyamfi Solomon , Stejskal Jan
Published: December 2020

The open innovation concept thrives on knowledge and information flow; their sources for the current innovation performance of the selected Central and Eastern European (CEE) countries have since triggered research interest. This research aimed to explore the different sources of knowledge and information for innovation and the extent to which these different sources contribute to the innovation performance of small and medium-sized enterprises in some selected CEE countries. The study assesses the influence of different knowledge and information sources and their relationships in SMEs engaged in manufacturing activities for innovation performance in the selected CEE countries using structural equation modeling. Data were sourced from the anonymized European Community Innovation Survey (CIS, 2012). The results show that internal sources of information and knowledge from innovative internal activities highly influence SMEs’ innovation performance in these CEE countries. Additionally, SMEs in the selected countries’ sources of information and knowledge influence firm cooperation arrangements. The result is significant for SMEs and policymakers to ensure fostering information and knowledge sharing and support of creating valuable knowledge for innovation, most importantly, in the aftermath of financial and economic crisis. AcknowledgmentThis work was supported by a grant provided by the scientific research project of the Czech Sciences Foundation Grant No. 20-03037S.
Vibration research of heavy trucks. Part 1: Sensitivity analysis of dynamic parameters on ride comfort
Authors: Hu Yongzhu , Nguyen Vanliem , Ye Yong
Published: December 2020

In order to study the influence of heavy truck dynamic parameters on the vehicle’s ride comfort under the random road excitation, the weighted RMS (root-mean-square) acceleration responses of the vertical driver’s seat and cab pitch angle are chosen as objective function, a dynamic model of the vehicle with 10 degrees of freedom is established to simulate and analyze the results. The influence of different parameters of all the suspension systems of the vehicle, such as the stiffness and damping of the suspensions of the seat, cab, vehicle, and wheel, on the vertical driver’s seat and cab pitch angle are respectively analyzed. The study results show that the influence of the stiffness and damping parameters in the suspension systems on the vehicle ride comfort is very obvious. The vehicle’s ride comfort changes worse with the increase of the suspension stiffness and the reduction of the suspension damping, and vice versa. The study proposes an optimal range of the stiffness and damping parameters for the optimal design and control of the vehicle suspension systems, concurrently, the study can also provide a theoretical basis for the suspension system designed for heavy trucks.
Myocardial Infarction in Systemic Lupus Erythematosus – the Sex-Specific Risk Profile
Authors: Vavlukis Marija , Pop-Gjorcevab Daniela , Poposka Lidija , Sandevska Emilija , Kedev Sasko
Published: December 2020

Background:

Accelerated atherosclerosis is widely present in patients with systemic lupus erythematosus.

Objective:

The aim of this review is to analyze the relationship between systemic lupus erythematosus and cardiovascular
diseases, with the emphasis on acute myocardial infarction.

Method:

We conducted a literature review through PubMed and Cochrane, using key words: SLE, atherosclerosis,
atherothrombosis, coronary artery disease, myocardial infarction, prognosis, sex specifics.

Results:

Various molecular mechanisms triggered by infection/inflammation are responsible for endothelial
dysfunction and the development of atherosclerosis at an earlier age. A contributing factor is the cumulative effect
of traditional cardiovascular risk factors interaction with disease-related characteristics. Myocardial infarction
rates are 2- to 10-fold higher compared to the general population. Young women have the highest relative
risk, however, men carry at least 3-fold higher risk than women. Coronary involvement varies from normal coronary
artery with thrombosis, coronary microartery vasculitis, coronary arteritis, and coronary atherosclerosis.
Typical clinical presentation is observed in men and older women, while atypical is more frequent in young
women. Treatment is guided by the underlying mechanism, engaging invasive procedures alone, or accompanied
with immunosuppressive and/or anti-inflammatory therapy. There are significant gender differences in
pathophysiology and clinical presentation. However, they receive the same therapeutic treatments.

Conclusion:

Systemic lupus erythematosus is a major contributor to atherosclerotic and non-atherosclerotic
mechanisms involved in the development of myocardial infarction, which should be taken into account during
therapeutic treatment. Although systemic lupus erythematosus per se is a “female” disease, males are at increased
cardiovascular risk and worse outcomes.
Pregnancy and Viral Hepatitis: Current Concepts
Authors: Cholongitas Evangelos , Tagkou Nikoletta M. , Kondylis Georgios
Published: December 2020

Viral hepatitis in pregnancy constitutes a complex issue, requiring meticulous management due to
the potential potent compromise of both mother’s and fetus’ health. Hepatitis B and C are implicated with a
high risk for chronicity, whereas hepatitis A and hepatitis E have an acute course. In pre-existing viral disease,
pregnancy may lead to exacerbation of the disease’s course due to a plethora of hormonal, immunological and
genetic alterations. Vice versa, viral hepatitis, acute or chronic, during pregnancy, can cause gestational complications
that may lead to significant maternal and neonatal morbidity and mortality. Mother to child transmission
of hepatitis B and C virus, in high prevalence areas, has been recognized as a major cause of chronic viral infection
and related complications in children. Due to the physiologic alterations in pregnancy, therapeutic indications
may differ from those in the general population and there is an expanding field of research on available
drugs and vaccines efficacy and safety during pregnancy. Of utmost importance remains the implementation of
a preventive strategy in order to reduce the rates of vertical transmission. Universal screening of pregnant women,
assessing the risk of transmission and determining the mode of delivery and the impact of breastfeeding are
crucial aspects of this strategy. This review summarizes the impact of viral hepatitis in pregnancy, strategies of
prevention of vertical transmission and available treatments.
Isatin Hybrids and Their Pharmacological Investigations
Authors: Varpe Bhushan D. , Kulkarni Amol A. , Jadhav Shailaja B. , Mali Anil S. , Jadhav Shravan Y.
Published: December 2020

Hybridization is an important strategy to design molecules that can be effectively used to
treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations
aided in discovering several potent isatin (Indole 2, 3 dione) derivatives with anti-HIV, antimalarial,
antitubercular, antibacterial, and anticancer activities. Indole-2,3-dione and their derivatives have diverse
pharmacological properties and have a prominent role in the discovery of new drugs. To understand
the various approaches for designing new molecules based on isatin nucleus analysis of various
pharmacophore hybrids, spacers/linkers between pharmacophores and isatin for hybridization and
their biological activities are important. This review discusses the progress in developing isatin hybrids
as biologically effective agents and their crucial aspects of design and structure-activity relationships.
In-silico Study to Identify Dietary Molecules as Potential SARS-CoV-2 Agents
Authors: Khan Mohammad Faheem , Khan Mohsin Ali , Khan Zaw Ali , Ahamad Tanveer , Ansari Waseem Ahmad
Published: December 2020

Background:

Recently, Coronavirus Disease-2019 (COVID-19), caused by a fatal strain
of coronavirus named Severe Acute Respiratory Syndrome-2 (SARS-CoV-2), has been declared as
a pandemic by the World Health Organisation (WHO) on 11 March 2020. Globally, no therapy
such as vaccines and specific therapeutic agents is available so far despite some protease inhibitors
and antiviral agents.

Introduction:

Due to no therapeutic drug or vaccine against SARS-CoV-2 so far, phytomedicine
may be developed as therapeutic agents in the prevention and treatment of current COVID-19 disease.
Thus, the aim of this study was to find out a suitable therapeutic agent from selected 17 dietary
molecules, which could target SARS-CoV-2 encoded proteins.

Materials and Methods:

In this study, 3D structures of selected dietary molecules were obtained from
the PubChem database, which have previously been reported for their antiviral and anti-inflammatory
effects. Then, molecular docking analysis by using AutoDoc4 and AutoDockVina software was conducted
to evaluate their anti-SARS-CoV-2 activity. Lipinski’s rule of five and drug-likeness properties
were also discussed with the help of Molinspiration and the OSIRIS property explorer methods.

Results:

Our results revealed that, among all, epigallocatechin gallate (EGCG) (7) is a lead compound
that could fit well into the binding sites of docked proteins of SARS-CoV-2. EGCG showed
very strong molecular interactions with the free enzyme of main protease (6y2e), chimeric receptorbinding
domain complexed with human ACE2 (6vw1), and NSP15 endoribonuclease (6vww) encoded
proteins of SARS-CoV-2, by showing binding energies -9.30, -8.66, and -8.38, kcal/mole,
respectively.

Conclusion:

In the present study, EGCG (7) is more active than two standard drugs that are currently
being used in COVID 19, namely remdesivir and nafamostat. Therefore, EGCG (7), as per our results,
might be explored as a therapeutic agent for the treatment of COVID-19.
Characteristics and Determinants of Pulse Pressure-Age Relationship in Healthy and Non-treated Hypertensive Subjects of Argentinean Population
Authors: Díaz Alejandro , Pascaner Ariel F. , Wray Sandra , Fischer Edmundo C.
Published: December 2020

Background:

The relationship between the increases in pulse pressure (PP) and arterial
stiffness determined by aging or systemic hypertension has been widely reported. These findings
are supported by large-cohort analyzes conducted in well-known populations, such as Framingham
Study. However, there is evidence that an age-PP curvilinear relationship may exist in hypertensive
subjects. This study aimed to evaluate the age-related change in pulse pressure and arterial stiffness
in a population-based study.

Methods:

Carotid-femoral Pulse Wave Velocity (cfPWV) were obtained in 2075 subjects.

Results:

Age-related changes of PP showed a curvilinear relationship (R=0.39, p<0.0001) in normotensive
subjects, with a nadir at around 50 years of age. On the other hand, the age-cfPWV relationship
showed a linear and positive correlation (R=0.72, p<0.0001). PP also showed a curvilinear
relationship with age (R=0.36, p<0.0001) in hypertensive subjects, with a nadir around 50 years of
age. The age-cfPWV relationship showed a linear and positive correlation (R=0.55, p<0.0001).
Similar results were observed in the adult population (age≥16 years). Multivariate analysis showed
that age, sex, cfPWV, and mean arterial pressure are determinants of PP values in the entire population;
however, this result was not uniform when different subgroups were analyzed.

Conclusion:

In conclusion, age-related changes in PP showed a curvilinear relationship and no parallelism
with the age-cfPWV relationship for both normotensive and hypertensive subjects. The determinants
of PP impact it differently depending on age and the pathological condition of the subject.
Myocardial Infarction with and without ST-segment Elevation: a Contemporary Reappraisal of Similarities and Differences
Authors: Mitsis Andreas , Gragnano Felice
Published: December 2020

Understanding the similarities and differences between myocardial infarction with or
without ST-segment elevation is an essential step for proper patients’ management in current practice.
Both syndromes are caused by critical stenosis or total occlusion of coronary arteries (mostly
due to thrombosis on atherosclerotic plaque), and manifest with a similar clinical presentation. Recent
epidemiologic studies show that the relative incidence of ST-segment elevation myocardial infarction
(STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) moves in an opposite
fashion (decreasing and increasing respectively), with a prognosis that is worse at short-term
follow-up for STEMI but comparable at long-term. Current management differs, as for STEMIs,
immediate reperfusion is recommended, while for NSTEMIs, risk stratification is mandatory in order
to stratify patients’ risk, and then decide the timing for coronary angiography. Periprocedural
and technical aspects of the interventional management, as well as antithrombotic medications, are
for the most similarly implemented in the two types of MI, with routine radial access, DES implant,
and novel P2Y12 inhibitors representing the standard of care in both cases.
The following review article aims to compare the two types of MI, with and without persistent STsegment
elevation. The main purpose is to explore their similarities and differences and address areas
of uncertainty with regards to clinical presentation, therapeutic management, and prognosis.
The identification of high-risk NSTEMI patients is important as they may require an individualised
approach that can substantially overlap with current STEMI recommendations, and their mortality
remains high if their management is delayed.
¡Ay, maricón! Analisando a tradução de tabus linguísticos na legendagem de La Mala Educación para o Português Brasileiro Um estudo comparativo entre legendas oficiais e fansubbing
Authors: Moura William Henrique Cândido
Published: December 2020

Considerando o avanço das pesquisas nos Estudos da Tradução Audiovisual nas últimas décadas, o presente trabalho objetivou vislumbrar se a tradução-da-letra (Berman 2013), proposta inicialmente para os estudos de tradução literária, pode ser considerada como uma metodologia para pesquisas em legendagem. Utilizamos as formas clássicas de tradução literária, etnocêntrica e hipertextual, e as tendências deformadoras da tradução para analisar um corpus composto pelas palavras e expressões-tabu relativas à injúria, encontradas nas legendas oficiais e nas legendas feitas por fansubbing, em português brasileiro, do filme espanhol La Mala Educación [Má Educação], de Pedro Almodóvar. Constatamos que a partir das análises das tendências deformadoras utilizadas, tanto nas legendas oficiais, quanto nas legendas do fansubbing, as palavras e expressões-tabu foram, em sua maioria, traduzidas de modo a não amenizar seu sentido, o que pôde ser explicado pelo fato de os legendadores terem realizado traduções mais voltadas para o etnocêntrico, prezando pelo significado que as legendas deveriam propiciar ao público que assiste ao filme. Concluímos que a teoria bermaniana pode ser utilizada como uma metodologia para a análise de legendas, desde que feitas algumas alterações, tendo em vista as características intrínsecas à legendagem.
Leveraging Contingency: Paradoxes of Neoliberal Speculation
Authors: Overwijk Jan
Published: December 2020

Review of Martijn Konings (2018) Capital and Time: For a New Critique of Neoliberal Reason. Stanford: Stanford University Press.
Sticking to the Long Road of Participatory Democracy: Replies to my Critics
Authors: Lafont Cristina
Published: December 2020

This essay is part of a dossier on Cristina Lafont's book Democracy without Shortcuts.
Can Truth (or Problem-Solving) Do More for Democracy?
Authors: Serrano Zamora Justo
Published: December 2020

This essay is part of a dossier on Cristina Lafont's book Democracy without Shortcuts.
How Dysfunctional Must Real-World Democracies Become Before Legislating by Deliberative Poll Would Be More Democratic?
Authors: Talbott William J.
Published: December 2020

This essay is part of a dossier on Cristina Lafont's book Democracy without Shortcuts.
Participation and Deliberation: Introduction to a Dossier on Cristina Lafont's Democracy without Shortcuts
Authors: Gabriëls René
Published: December 2020

Introduction to a dossier on Cristina Lafont's Democracy without Shortcuts.
Письма как художественный текст и политическое мастерство
Authors: Вачева Ангелина
Published: December 2020

Kelsey Rubin-Detlev. The Epistolary Art of Catherine the Great. Liverpool: Liverpool University Press on behalf of the Voltaire Foundation, 2019, 416 p. ISBN 9781789620078
Exploring the Feasibility of Relapse Prevention Strategies in Interdisciplinary Multimodal Pain Therapy Programs: Qualitative Study (Preprint)
Authors: Elbers Stefan , Pool Jan , Wittink Harriët , Köke Albère , Smeets Rob
Published: December 2020

BACKGROUND

Although interdisciplinary multimodal pain treatment (IMPT) programs are widely regarded as treatment of choice for patients with chronic pain, there are signs that many patients are unable to maintain their treatment gains in the long term. To facilitate the maintenance of positive treatment outcomes over time, we developed two relapse prevention strategies.

OBJECTIVE

The main objective of this study was to explore the feasibility of these strategies within the context of IMPT programs.

METHODS

We performed a feasibility study using 3 workbook prototypes containing either one or both strategies. For a period of 6 months, the workbooks were made available in two IMPT facilities. Qualitative data were collected through a focus group and semistructured interviews. We performed a thematic analysis using a deductive approach with (1) applicability to the treatment program, (2) acceptability of the workbook content, and (3) form, as predefined themes.

RESULTS

The final dataset consisted of transcripts from a focus group with health care providers and 11 telephone interviews and 2 additional in-depth interviews with patients. In general, the intervention was perceived as useful, easy to use, and in line with the treatment program. The data also include suggestions to further improve the use of both strategies, including more specific implementation guidelines, revised goal-setting procedure, and development of a mobile health version. However, several factors, including a high dropout rate and small sample size, impact the external validity of our findings.

CONCLUSIONS

This study should be regarded as a first step in the process of transforming the prototype workbook into an effective intervention for clinical practice. Although these initial results indicate a favorable evaluation of both behavior regulation strategies within the workbook, this study encountered multiple barriers regarding implementation and data collection that limit the generalizability of these results. Future research efforts should specifically address the fidelity of HCPs and patients and should include clear procedures regarding recruitment and use of both relapse prevention strategies during treatment.
Effect of the Virtual Simulation Teaching Software of Free Position Childbirth in Midwife Continuing Education: Randomized Controlled Trial (Preprint)
Authors: Lin Hui Min , Guo Sheng Bin , Hu Rong Fang , Wu Tao Hong , Xie Na Mei
Published: December 2020

BACKGROUND

Providing the birthing woman with freedom of position has very significant advantages over traditional supine posture. Unfortunately, the rate of free position is not satisfactory worldwide. In China, as the main provider, the lack of ability of midwives greatly restricts the use of position. While the mechanism of action of position is abstract and complex, virtual simulation technology may make it easier for midwives to master.

OBJECTIVE

This study aimed to explore the application effects of the blended teaching method in midwives continuing education by combining online learning with conventional lecturing.

METHODS

A parallel randomized controlled trial was conducted. A total of 41 midwives from a childbirth room were enrolled and randomly assigned to two groups. The midwives in the experimental group (n=21) received a training program using the blended learning method, and the midwives in the control group (n=20) received a traditional teaching method. Using the Kirkpatrick Model to evaluate the training effects from four levels (Reaction, Learning, Behavior, Results).

RESULTS

The satisfaction of the experimental group on teaching aids, learning atmosphere, and overall satisfaction was higher than that of the control group (P＜0.05). The knowledge scores of both groups were significantly improved (P＜0.001), and the experimental group’s knowledge and skill scores were higher than the control group (P＜0.05). The scores of clarifying maternal position needs and guiding family members to cooperate with the mother significantly improved in the experimental group, which were higher than those in the control group. The rate of non-supine childbirth in the experimental group increased significantly (P=0.030). The rate of perineal incision in primiparas was lower than that in the control group (P=0.040), and it was lower than before training (P=0.035).

CONCLUSIONS

The blended learning can increase midwives' satisfaction with training conditions and training effects, better improve knowledge and skills, accelerate the positive change of attitude towards in free position, increase the rate of childbirth in non-supine position，and reduce the rate of perineal incision in primiparas.
Correction: Mobile Apps for Speech-Language Therapy in Adults With Communication Disorders: Review of Content and Quality (Preprint)
Authors: Vaezipour Atiyeh , Campbell Jessica , Theodoros Deborah , Russell Trevor
Published: December 2020

UNSTRUCTURED

Worldwide, more than 75% of people with acquired brain injury (ABI) experience communication disorders. Communication disorders are impairments in the ability to communicate effectively, that is, sending, receiving, processing, and comprehending verbal and nonverbal concepts and symbols. Such disorders may have enduring impacts on employment, social participation, and quality of life. Technology-enabled interventions such as mobile apps have the potential to increase the reach of speech-language therapy to treat communication disorders. However, ensuring that apps are evidence-based and of high quality is critical for facilitating safe and effective treatment for adults with communication disorders. The aim of this review is to identify mobile apps that are currently widely available to adults with communication disorders for speech-language therapy and to assess their content and quality using the validated Mobile App Rating Scale(MARS). Google Play Store, Apple App Store, and webpages were searched to identify mobile apps for speech-language therapy. Apps were included in the review if they were designed for the treatment of adult communication disorders after ABI, were in English, and were either free or for purchase. Certified speech-language pathologists used the MARS to assess the quality of the apps. From a total of 2680 apps identified from Google Play Store, Apple App Store, and web searches, 2.61% (70/2680) apps met the eligibility criteria for inclusion. Overall, 61% (43/70) were available for download on the iPhone Operating System (iOS) platform, 20% (14/70) on the Android platform, and 19% (13/70) on both iOS and Android platforms. A content analysis of the apps revealed 43 apps for language, 17 apps for speech, 8 apps for cognitive communication, 6 apps for voice, and 5 apps for oromotor function or numeracy. The overall MARS mean score was 3.7 out of 5, SD 0.6, ranging between 2.1 and 4.5, with functionality being the highest-scored subscale (4.3, SD 0.6), followed by aesthetics (3.8, SD 0.8), information (3.4, SD 0.6), and engagement (3.3, SD 0.6). The top 5 apps were Naming Therapy (4.6/5), Speech Flipbook Standard (4.6/5), Number Therapy(4.5/5), Answering Therapy, and Constant Therapy (4.4/5). To our knowledge, this is the first study to systematically identify and evaluate a broad range of mobile apps for speech-language therapy for adults with communication disorders after sustaining ABI. We found a lack of interactive and engaging elements in the apps, a critical factor in sustaining self-managed speech-language therapy. More evidence-based apps with a focus on human factors, user experience, and a patient-led design approach are required to enhance effectiveness and long-term use.
Pemantauan dan Pengendalian Parameter Akuaponik Menggunakan Representational State Transfer Application Programming Interface
Authors: Helmy  , Athadhia Febyana  , Agung Al Rasyid  , Arif Nursyahid  , Thomas Agung Setyawan  , Ari Sriyanto Nugroho
Published: December 2020

Akuaponik merupakan penggabungan antara akuakultur dengan hidroponik. Salah satu sistem hidroponik yaitu sistem drip (tetes). Parameter yang perlu diperhatikan dalam budidaya akuaponik antara lain keasaman larutan nutrisi yaitu pH, suhu air, dan larutan nutrisi yang ditunjukkan oleh kepekatan zat padat terlarut dalam air (Total Dissolved Solids, TDS). Nutrisi tanaman diperoleh dari kotoran ikan yang mengandung nitrogen. Oleh karena itu, diperlukan pemantauan pH, TDS, dan suhu secara realtime dan pengendalian kelembapan tanah pada tanaman akuaponik agar tanaman tidak kekurangan nutrisi. Proses pengendalian menggunakan Representational State Transfer Application Programming Interface (REST API) dalam menerima nilai batas ambang yang ditentukan petani akuaponik melalui situs web dan mengirimkan nilai kelembapan tanah dan parameter kolam ikan berupa pH, suhu dan TDS ke server. Pengujian data loss dan delay pada sistem pemantauan dan pengendalian ini diperlukan untuk mengetahui keandalan alat dalam pengiriman dan penerimaan data. Selain itu, diperlukan notifikasi berupa e-mail kepada petani apabila nilai kelembapan tanah kurang dari batas ambang. Hasil pengujian menunjukkan sistem dapat mengirimkan notifikasi berupa e-mail kepada petani apabila nilai kelembapan tanah kurang dari batas ambang, rerata delay pemantauan node-gateway sebesar 6,01 detik, sedangkan rerata delay pemantauan gateway–server sebesar 10,02 detik, dan rerata delay pengendalian server–gateway sebesar 92,55 detik.
Arqueología andina venezolana
Authors: Wagner Erika
Published: December 2020

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Middle ear barotrauma during hyperbaric oxygen therapy; a review of occurrences in 5,962 patients
Authors:   Vulnology and Diabetic Foot Unit, Casa di Cura “Dr. Pederzoli”, Peschiera, Verona, Italy, Nasole Emanuele ,   OTOSUB, Italian group of ENT professionals with subaquatic scientific interest, Italy, Zanon Vincenzo ,   DHMU at ICCB, Istituti Ospedalieri Bresciani, GSD - University & Research Hospitals, Brescia, Italy,   II level Master in Diving and Hyperbaric Medicine, Department of Biomedical Sciences, University of Padova, Padova, Italy, Marcolin Paolo ,   OTOSUB, Italian group of ENT professionals with subaquatic scientific interest, Italy,   II level Master in Diving and Hyperbaric Medicine, Department of Biomedical Sciences, University of Padova, Padova, Italy, Bosco Gerardo ,   II level Master in Diving and Hyperbaric Medicine, Department of Biomedical Sciences, University of Padova, Padova, Italy
Published: December 2020

Hyperbaric-associated middle ear barotrauma (MEB) is one of the most common side effects of the exposure to hyperbaric oxygen (HBO2) therapy. This retrospective observational study of 5,962 patients undergoing long-term therapy for chronic conditions took place at the local Diving & Hyperbaric Medicine Unit (DHMU) in Villafranca- Verona (Italy), a DHMU that administers, in multiplace chambers, more than 20,000 HBO2 treatments per year. The study was designed to weight and analyze both the incidence and severity of MEBs at the facility. Thanks to a systematic recording method over eight years, 2003-2010, we observed 549 MEBs (9.2% of all HBO2 treatments). The majority of them were female patients older than 50. MEBs observed were usually of minor complexity, with minimal otoscopic changes (69.03% of our occurrences were registered as Wallace-Teed Grade 1). MEBs were registered in 20.3% of those patients already suffering from difficulties in equalizing ear pressure, and/or presenting ear pain during the initial compression phase (descent) of the hyperbaric treatment. Inflammatory diseases of the upper respiratory tract, with special attention to rhinitis, appear to be a condition capable of predisposing patients in developing MEB. MEB did lead to the suspension of therapy for 89 patients in our case series. This was 16.2% of all the MEBs registered, or 1.49% of all patients who underwent HBO2 at the facility in the considered time lapse.
Methods for preventing middle ear barotrauma in computer-controlled pressurization of monoplace hyperbaric chambers
Authors: Hwang Layoung , Song Moon , Lee Yoonsuk , Shin Tae Min ,   Department of Biomedical Engineering, Yonsei University, Wonju, Korea
Published: December 2020

Middle ear barotrauma (MEB), one of the side effects of hyperbaric oxygen (HBO2) therapy, sometimes cannot be directly diagnosed during the therapy itself. Instead, its incidence and degree are judged based on subjective statements made by patients when in conversation with medical staff regarding how they feel. To prevent MEB in practice it is proposed that the tympanic membrane evaluation system and automatic control chamber developed in a previous study be applied as part of a prevention algorithm [16]. The proposed algorithm, which determines and equalizes the unbalanced pressure of a subject based on their tympanic admittance, was evaluated in conjunction with conventional HBO2 therapy in an experiment involving 100 subjects. Among the 50 subjects in the control group who received HBO2 therapy 16 subjects experienced MEB. In contrast, the experimental group of 50 subjects were treated with a hyperbaric chamber protocol incorporating the automatic control system and proposed algorithm. At the conclusion of the treatment, no subjects exhibited middle ear barotrauma. In the case of the control group, while the target pressure was achieved, middle ear barotrauma still occurred. However, in the case of the experimental group, the pressure inside the chamber was adjusted as per the algorithm, which allowed the target pressure for every subject to be achieved without experiencing MEB. When a particular subject was unable to perform any pressure equalization method such as swallowing or the Valsalva maneuver, the chamber was not pressurized based on the tympanic admittance and thus no MEB occurred.
Testing an operation of prototype for automated assessment: case of visitor profile of Gauja National Park
Authors:   Vidzeme University of Applied Sciences, Berzina Iluta , Balodis Edgars ,   Vidzeme University of Applied Sciences
Published: December 2020

This study is based on the authors’ research started in 2017 that resulted in the development of theoretical strategic and tactical models for the construction of a prototype for automated assessment of tourism economic impact in specific regions, including regions of national parks (NP), as well as for other studies. The aim of the research was testing the performance of the prototype in a research e-environment using the travellers’ survey data obtained in a study in 2019 on the national parks’ target groups (visitor behaviour) during the Gauja National Park (GNP) Travellers’ Days. The prototype was based on the open-source platform Drupal, MySQL used as a database management system (DMS). Drupal united with the Jupyter Notebook platform. The methodological substantiation of the test study is based on aspects of consumer behaviour. A quantitative study with details of qualitative research has been performed. Simple data sampling was used in the data acquisition, but in the analysis – induction, deduction approach, synthesis, data sorting and segmentation, determination of mean values and their expression in proportion; a comparative analysis was performed and conclusions characterizing the sample were made. After completing the prototype performance testing, the authors’ main findings indicate that the prototype’s performance efficiency in terms of time consumption is 23.3 times higher than equivalent work in MS Excel. The prototype has yielded quantitative results from the calculations, and that allows the formulation of the GNP’s Travellers’ Days visitor profile, which is characterized by a sample of the surveys.
Security Enhancement of an Automated Teller Machine Using Fingerprint and Password
Authors:   Augustine University, Epe, Lagos State, Nigeria, Nwankwo C. , Oletu G. , Longe O.B.
Published: December 2020

This paper focuses on how to enhanced security of Transactions in Automatic Teller Machine system using a multi-factor authentication system (Password and Fingerprint). In order to achieve security and to overcome illegal activities, shortcoming of piracy in money transactions, we propose the idea of using fingerprints of customers and password instead of traditional use of PIN number. After authorized verification, the customer will be able to proceed for transaction else after four successive wrong attempts, the ATM card will be ejected automatically and a message will be sent to the registered mobile number. The proposed system is developed to provide better security to the ATMs. Keywords— ATM, Fingerprint, PIN, Biometric.
Towards the Analysis and Prediction of Early Childhood Development Using Data Mining Classification Techniques
Authors:   School of IT & Computing, American University of Nigeria, Yola, Nigeria, Aimufua I. , Rakshit S , Vajjhala N.R. , Longe O.B.
Published: December 2020

In recent years, the use of technology in almost every sector has been on the increase, which has lead to massive growth in the generation and usage of data. Medical, Business and other leading industries have surveyed and noted that data repositories will be a useful tool in the designing of business strategies, analyzing of unstructured and structure data in other to gain useful knowledge. Keywords: Early Childhood Development Analysis and Prediction Using Data Mining Classification Techniques
Development of One-Time Password (OTP) for ATM/POS : A Review of Related Works
Authors:   Department of Information Technology National Open University of Nigeria Yola, Nigeria, Jurgene S. , Longe O.B.
Published: December 2020

This study is aimed at designing a One-Time Password (OTP) for ATM/POS. The emergence of the Internet Banking leads to the Introduction of Plastic payment cards that provide a suitable and secure medium which people conduct a variety of financial transactions. But with this exciting innovation, it has also led to crime opportunities called “PLASTIC FRAUDS”. Notwithstanding, this crime must be controlled and that is why the banks must adopt a preventive and proactive method to fight the crimes. This calls for a One-Time Password (OTP) for ATM/POS. In this paper, we reviuewed Related Literaure and set the agenda for the research. Abstract- One-Time Password (OTP), ATM/POS, Security, Online Banking, Protection
Depletion of adipocyte Becn1 leads to lipodystrophy and metabolic dysregulation
Authors: Admin Ada , Jin Young , Ji Yul , Song Yaechan , Choe Sung Sik , Jeon Yong Geun , Na Heeju , Nam Tae Wook , Kim Hye Jeong , Nahmgoong Hahn , Kim Sung Min , Kim Jae-woo , Nam Ki Taek , Seong Je Kyung , Hwang Daehee , Park Chan Bae , Lee In Hye , Kim Jae Bum , Lee Han-Woong
Published: December 2020

Becn1/Beclin-1 is a core component
of the
class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although
Becn1 has been implicated in numerous
diseases such as cancer, aging, and neurodegenerative disease, the role of Becn1 in white adipose tissue and
related metabolic diseases remains elusive. Here we show that adipocyte-specific
Becn1 knockout mice develop severe
lipodystrophy, leading to adipose tissue inflammation, hepatic steatosis,
insulin resistance. Ablation of Becn1
in adipocytes stimulates programmed cell death in a cell-autonomous
manner, accompanied by elevated ER stress gene
expression. Furthermore, we observed that Becn1
depletion sensitized mature adipocytes to ER stress, leading to accelerated
cell death. Taken together, these data suggest that adipocyte Becn1 would serve as a crucial player
for adipocyte survival and adipose tissue homeostasis.