bluuebunny/crossref_metadata_2025 huggingface dataset:
Classifying beams carrying orbital angular momentum with machine learning: tutorial
Authors: Avramov-Zamurovic Svetlana , Esposito Joel M. , Nelson Charles
Published: November 2022

This tutorial discusses optical communication systems that propagate light carrying orbital angular momentum through random media and use machine learning (aka artificial intelligence) to classify the distorted images of the received alphabet symbols. We assume the reader is familiar with either optics or machine learning but is likely not an expert in both. We review select works on machine learning applications in various optics areas with a focus on beams that carry orbital angular momentum. We then discuss optical experimental design, including generating Laguerre–Gaussian beams, creating and characterizing optical turbulence, and engineering considerations when capturing the images at the receiver. We then provide an accessible primer on convolutional neural networks, a machine learning technique that has proved effective at image classification. We conclude with a set of best practices for the field and provide an example code and a benchmark dataset for researchers looking to try out these techniques.
Bidirectional remote hyperstate preparation under common quantum control using hyperentanglement
Authors: Bich Cao Thi , Ba An Nguyen
Published: November 2022

In this paper, we propose a new, to the best of our knowledge, protocol that enables two distant parties to prepare a photon hyperstate for each other encoded at the same time in both polarization and spatial-mode degrees of freedom. The bidirectional remote hyperstate preparation is demanded so that it is remotely controllable by a common supervisor. Such a task appears possible using a shared quantum channel made of five photons entangled simultaneously in the two corresponding degrees of freedom, the so-called hyperentanglement. We first design a near-deterministic scheme to produce a relevant five-photon hyperentanagled state to be served as the working nonlocal channel and then present our protocol for controlled bidirectional remote hyperstate preparation, which always is successful.
SyBLaRS: A web service for laying out, rendering and mining biological maps in SBGN, SBML and more
Authors: Balci Hasan , Dogrusoz Ugur , Ozgul Yusuf Ziya , Atayev Perman
Published: November 2022

Visualization is a key recurring requirement for effective analysis of relational data. Biology is no exception. It is imperative to annotate and render biological models in standard, widely accepted formats. Finding graph-theoretical properties of pathways as well as identifying certain paths or subgraphs of interest in a pathway are also essential for effective analysis of pathway data. Given the size of available biological pathway data nowadays, automatic layout is crucial in understanding the graphical representations of such data. Even though there are many available software tools that support graphical display of biological pathways in various formats, there is none available as a service for on-demand or batch processing of biological pathways for automatic layout, customized rendering and mining paths or subgraphs of interest. In addition, there are many tools with fine rendering capabilities lacking decent automatic layout support.

To fill this void, we developed a web service named SyBLaRS (SystemsBiologyLayout andRenderingService) for automatic layout of biological data in various standard formats as well as construction of customized images in both raster image and scalable vector formats of these maps. Some of the supported standards are more generic such as GraphML and JSON, whereas others are specialized to biology such as SBGNML (The Systems Biology Graphical Notation Markup Language) and SBML (The Systems Biology Markup Language). In addition, SyBLaRS supports calculation and highlighting of a number of well-known graph-theoretical properties as well as some novel graph algorithms turning a specified set of objects of interest to a minimal pathway of interest.

We demonstrate that SyBLaRS can be used both as an offline layout and rendering service to construct customized and annotated pictures of pathway models and as an online service to provide layout and rendering capabilities for systems biology software tools.

SyBLaRS is open source and publicly available onGitHuband freely distributed under the MIT license. In addition, a sample deployment is availableherefor public consumption.
Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models
Authors: Cortés-Ríos Javiera , Hermida Ramón C. , Rodriguez-Fernandez Maria
Published: November 2022

Blood pressure (BP) follows a circadian variation, increasing during active hours, showing a small postprandial valley and a deeper decrease during sleep. Nighttime reduction of 10–20% relative to daytime BP is defined as a dipper pattern, and a reduction of less than 10%, as a non-dipper pattern. Despite this BP variability, hypertension’s diagnostic criteria and therapeutic objectives are usually based on BP average values. Indeed, studies have shown that chrono-pharmacological optimization significantly reduces long-term cardiovascular risk if a BP dipper pattern is maintained. Changes in the effect of antihypertensive medications can be explained by circadian variations in their pharmacokinetics (PK) and pharmacodynamics (PD). Nevertheless, BP circadian variation has been scarcely included in PK-PD models of antihypertensive medications to date. In this work, we developed PK-PD models that include circadian rhythm to find the optimal dosing time (Ta) of first-line antihypertensive medications for dipper and non-dipper patterns. The parameters of the PK-PD models were estimated using global optimization, and models were selected according to the lowest corrected Akaike information criterion value. Simultaneously, sensitivity and identifiability analysis were performed to determine the relevance of the parameters and establish those that can be estimated. Subsequently, Ta parameters were optimized to maximize the effect on BP average, BP peaks, and sleep-time dip. As a result, all selected models included at least one circadian PK component, and circadian parameters had the highest sensitivity. Furthermore, Ta with which BP>130/80 mmHg and a dip of 10–20% are achieved were proposed when possible. We show that the optimal Ta depends on the therapeutic objective, the medication, and the BP profile. Therefore, our results suggest making chrono-pharmacological recommendations in a personalized way.
The Rheb GTPase promotes pheromone blindness via a TORC1-independent pathway in the phytopathogenic fungus Ustilago maydis
Authors: de la Torre Antonio , Pérez-Martín José
Published: November 2022

The target of the rapamycin (TOR) signaling pathway plays a negative role in controlling virulence in phytopathogenic fungi. However, the actual targets involved in virulence are currently unknown. Using the corn smut fungusUstilago maydis, we tried to address the effects of the ectopic activation of TOR on virulence. We obtained gain-of-function mutations in the Rheb GTPase, one of the conserved TOR kinase regulators. We have found that unscheduled activation of Rheb resulted in the alteration of the proper localization of the pheromone receptor, Pra1, and thereby pheromone insensitivity. Since pheromone signaling triggers virulence in Ustilaginales, we believe that the Rheb-induced pheromone blindness was responsible for the associated lack of virulence. Strikingly, although these effects required the concourse of the Rsp5 ubiquitin ligase and the Art3 α-arrestin, the TOR kinase was not involved. Several eukaryotic organisms have shown that Rheb transmits environmental information through TOR-dependent and -independent pathways. Therefore, our results expand the range of signaling manners at which environmental conditions could impinge on the virulence of phytopathogenic fungi.
Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability
Authors: Simo Cheyou Estelle , Boni Jacopo , Boulais Jonathan , Pinedo-Carpio Edgar , Malina Abba , Sherill-Rofe Dana , Luo Vincent M. , Goncalves Christophe , Bagci Halil , Maters Alexandra , Cuella-Martin Raquel , Tabach Yuval , del Rincon Sonia , Côté Jean-Francois , Rivera Barbara , Orthwein Alexandre
Published: November 2022

Homologous recombination (HR) plays an essential role in the maintenance of genome stability by promoting the repair of cytotoxic DNA double strand breaks (DSBs). More recently, the HR pathway has emerged as a core component of the response to replication stress, in part by protecting stalled replication forks from nucleolytic degradation. In that regard, the mammalian RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) have been involved in both HR-mediated DNA repair and collapsed replication fork resolution. Still, it remains largely obscure how they participate in both processes, thereby maintaining genome stability and preventing cancer development. To gain better insight into their contribution in cellulo, we mapped the proximal interactome of the classical RAD51 paralogs using the BioID approach. Aside from identifying the well-established BCDX2 and CX3 sub-complexes, the spliceosome machinery emerged as an integral component of our proximal mapping, suggesting a crosstalk between this pathway and the RAD51 paralogs. Furthermore, we noticed that factors involved RNA metabolic pathways are significantly modulated within the BioID of the classical RAD51 paralogs upon exposure to hydroxyurea (HU), pointing towards a direct contribution of RNA processing during replication stress. Importantly, several members of these pathways have prognostic potential in breast cancer (BC), where their RNA expression correlates with poorer patient outcome. Collectively, this study uncovers novel functionally relevant partners of the different RAD51 paralogs in the maintenance of genome stability that could be used as biomarkers for the prognosis of BC.
Pregnant women’s knowledge of obstetrical danger signs: A cross-sectional survey in Kigali, Rwanda
Authors: Uwiringiyimana Emmanuel , Manirambona Emery , Byiringiro Samuel , Nsanzimana Albert , Uhawenayo Neophyte , Ufitinema Pacifique , Bayizere Janviere , Moreland Patricia J. , Meharry Pamela , Ntasumbumuyange Diomede
Published: November 2022

Maternal mortality remains critically high in low- and middle-income countries (LMIC), particularly in sub-Saharan Africa. Rwanda’s leading causes of maternal death include postpartum hemorrhage and obstructed labor. Maternal recognition of obstetrical danger signs is critical for timely access to emergency care to reduce maternal mortality.To assess maternal knowledge of obstetrical danger signs among pregnant women attending antenatal care services in Kigali, Rwanda. We conducted a cross-sectional study between September and December 2018. The outcome of interest was maternal knowledge of ODS during pregnancy, labor and delivery, and the immediate postpartum period. We recruited pregnant women at five health centers, one district hospital, and one referral hospital, and we had them complete a structured questionnaire. Reporting three correct ODS was defined as having good knowledge of ODS. A total of 382 pregnant women responded to the survey. Most women (48.9%) were aged 26–35, and 50.5% had completed secondary or higher education. The knowledge of ODS was 56%, 9%, and 17% during pregnancy, labor and delivery, and postpartum, respectively. Women aged 26 to 35 had two times (OR: 1.80, 95% CI: 1.05, 3.06) higher odds of ODS knowledge during pregnancy than women aged 16 to 25. Attending three antenatal care visits was associated with 2.6 times (OR: 2.59, 95% CI: 1.17, 5.66) higher odds of ODS knowledge during pregnancy than not attending any visit. Longer distances to the nearby health facility were associated with significantly lower knowledge during pregnancy, and Muslim women had substantially higher postpartum ODS knowledge than any other religion. In conclusion, women’s knowledge of ODS associated with labor and delivery and postpartum was low. Antenatal care must be encouraged and its content revised to ensure it covers potential late pregnancy complications.
Efficacy and safety of a new ranibizumab biosimilar CKD-701 using a pro re nata treatment regimen in neovascular age-related macular degeneration: A phase 3 randomized clinical trial
Authors: Yoon Chang Ki , Oh Jaeryung , Bae Kunho , Park Un Chul , Yu Kyung-Sang , Yu Hyeong Gon
Published: November 2022

Purpose

This study aimed to establish the efficacy, safety, and immunogenicity equivalence of the proposed biosimilar CKD-701 with the reference ranibizumab in patients with treatment-naïve neovascular age-related macular degeneration (nAMD).

Patients and methods

A total of 312 participants with active subfoveal choroidal neovascularization were randomly assigned to either the CKD-701 (n = 156) or reference ranibizumab (n = 156) arms. The initial 3-month loading intraocular injections were followed by pro re nata (PRN) dosing for 9 months. The primary outcome was the proportion of patients with less than 15-letters of corrected visual acuity (BCVA) loss at 3 months visit (one month after last loading injection) compared to the baseline time point. The presence of retinal fluid, and changes in BCVA and central retinal thickness (CRT) were assessed as secondary efficacy outcomes. Immunogenicity and safety were evaluated in both treatment arms.

Results

In the CKD-701 arm, 143 (97.95%) patients lost <15 letters in the BCVA at 3 months compared to 143 (98.62%) in the reference arm (P = 0.67). The BCVA improved with a mean improvement of +7.0 (CKD-701) and +6.2 (ranibizumab) letters at 3 months (P = 0.43). The least-squares mean (SE) changes in CRT at 3 months from the baseline were −119.3 (12.0) μm and −124.5 (11.9) μm in the CKD-701 and ranibizumab groups, respectively (P = 0.74). The proportion of participants with subretinal or intraretinal fluid at 3, 6, and 12 months was similar between the study arms. The number (SE) of injections were 8.36 (3.13) in the CKD-701 and 8.26 (2.92) in ranibizumab (P = 0.62). The occurrence of adverse events and antidrug antibody in the study arms were also not statistically different.

Conclusion

CKD-701 is a biosimilar to the reference ranibizumab in terms of efficacy, safety, and immunogenicity for the treatment of patients with nAMD. Moreover, improvement and maintenance of visual outcome were achieved through PRN regimen.
What is important for people with type 2 diabetes? A focus group study to identify relevant aspects for Patient-Reported Outcome Measures in diabetes care
Authors: Abdel-Rahman Nura , Manor Orly , Valinsky Liora , Mosenzon Ofri , Calderon-Margalit Ronit , Roberman Sveta
Published: November 2022

Background

Patient-Reported Outcome Measures (PROMs) aim to evaluate the quality of care based on the perspectives of patients rather than clinical indicators. Qualitative research is needed to identify these perspectives in people with type 2 diabetes.

Objective

To identify, for the first time in Israel, aspects valuable for people with type 2 diabetes that can be relevant for PROMs in diabetes care.

Methods

A qualitative study included three focus groups totalling 19 people with type 2 diabetes. Inclusion criteria were: (1)type 2 diabetes, (2)diabetes duration of at least six months, and (3)adults aged 45–80 years. Purposive sampling enabled recruitment of heterogeneous participants. Also, two experts’ panels with healthcare providers involved in diabetes care (n = 23) were conducted to provide triangulation of information (more testimony about what is valuable for people with type 2 diabetes). Discussions were recorded, transcribed and thematically analysed.

Results

Four domains were deemed valuable for people with type 2 diabetes: (1)challenges of living with diabetes, including reduced physical function, healthy lifestyle struggles, sexual dysfunction, and financial burden, (2)mental health issues, including depression, distress, anxiety, frustration, and loneliness, (3)self-management ability, including management of lifestyle modifications and treatment, knowledge about the disease and treatment, and (4)patient-clinician relationships, including the devotion of clinicians, trust in clinicians and treatment, shared decision-making, and multidisciplinary care under one roof. Experts favour using PROMs in diabetes routine care and even acknowledged their necessity to improve the treatment process. However, only some of the domains raised by people with type 2 diabetes were identified by the experts.

Conclusions

There are content gaps between perspectives of people with type 2 diabetes and their healthcare providers. PROMs are essential in addressing issues largely not addressed in routine diabetes care. We recommend that researchers and healthcare providers, who intend to utilize PROMs for diabetes care, consider the aforementioned domains.
Predictors of sputum culture conversion time among MDR/RR TB patients on treatment in a low-income setting
Authors: Meshesha Meiraf Daniel
Published: November 2022

Objective

This study aimed to assess the time to first culture conversion and its predictors among MDR/RR-TB cases enrolled in Dilchora Hospital.

Method

A retrospective cohort study was conducted among MDR/RR TB cases enrolled between January 2014 and December 2018. SPSS version 26 was used for analysis. Reports are presented using percentages and frequency. Independent predictors of time-to-culture conversion were identified using multivariate Cox proportional hazard regression. Adjusted and crude hazard ratio with 95% CI was used. P-value< 0.05 declared statistical significance.

Result

A total of 145 MDR/RR TB cases were included. The median time to culture conversion was at 2 months. Higher baseline hemoglobin [AHR:1.101(1.02–1.19)] and having a non-cavitary lesion on chest x-ray[AHR:1.803(1.15–2.83)] predicted a higher likelihood of early culture conversion. Resistance to at least one first-line anti-TB drug in addition to rifampicin was associated with a lower hazard of early culture conversion as compared to only rifampicin resistance[AHR: 0.577(0.37–0.91)].

Conclusion & recommendation

A baseline hemoglobin level, chest x-ray finding of cavitation and resistance to rifampicin, and at least one additional drug predicted the time to culture conversion. A closer treatment monitoring and follow-up should be emphasized for those presenting with lower baseline hemoglobin, more drug resistance, and cavitation on chest x-ray.
A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins
Authors: Sitaram Anand , Yin Yunqiang , Zamaitis Tammy , Zhang Bo , Aroian Raffi V.
Published: November 2022

Pore-forming proteins (PFPs) comprise the largest single class of bacterial protein virulence factors and are expressed by many human and animal bacterial pathogens. Cells that are attacked by these virulence factors activate epithelial intrinsic cellular defenses (or INCEDs) to prevent the attendant cellular damage, cellular dysfunction, osmotic lysis, and organismal death. Several conserved PFP INCEDs have been identified using the nematode Caenorhabditis elegans and the nematicidal PFP Cry5B, including mitogen-activated protein kinase (MAPK) signaling pathways. Here we demonstrate that the gene nck-1, which has homologs from Drosophila to humans and links cell signaling with localized F-actin polymerization, is required for INCED against small-pore PFPs in C. elegans. Reduction/loss of nck-1 function results in C. elegans hypersensitivity to PFP attack, a hallmark of a gene required for INCEDs against PFPs. This requirement for nck-1-mediated INCED functions cell-autonomously in the intestine and is specific to PFPs but not to other tested stresses. Genetic interaction experiments indicate that nck-1-mediated INCED against PFP attack is independent of the major MAPK PFP INCED pathways. Proteomics and cell biological and genetic studies further indicate that nck-1 functions with F-actin cytoskeleton modifying genes like arp2/3, erm-1, and dbn-1 and that nck-1/arp2/3 promote pore repair at the membrane surface and protect against PFP attack independent of p38 MAPK. Consistent with these findings, PFP attack causes significant changes in the amount of actin cytoskeletal proteins and in total amounts of F-actin in the target tissue, the intestine. nck-1 mutant animals appear to have lower F-actin levels than wild-type C. elegans. Studies on nck-1 and other F-actin regulating proteins have uncovered a new and important role of this pathway and the actin cytoskeleton in PFP INCED and protecting an intestinal epithelium in vivo against PFP attack.
Digital dynamic visual identities : Prospects at the frontiers of marketing and design
Authors: Fekete Balázs
Published: November 2022

A logo is worth more than a thousand words. But how much are thousands of logos worth? Contemporary visual communication toolkit of companies and brands is becoming more and more technology-driven and extended by Dynamic Visual Identity (DVI) systems. Algorithmic, data-based, interactive DVIs promise unprecedented opportunities to brands and pose new challenges for designers and marketers. This paper explores the characteristics of generative type digital dynamic visual identities with the aim of stimulating interdisciplinary discourse and scientific examination at this frontier of marketing and design. The current study applied qualitative inquiry to a curated sample of contemporary visual systems designed after 2013. By using content analysis and the designcommunication (DIS:CO) approach the authors identified three dimensions that are suitable for the examination, and development of DVI cases regardless of the industry, technology and media used. Explanations are illustrated by the award-winning DVIs of world-renowned agencies such as Pentagram, Saffron, and Lava.
The Epidemiology and Epistemology of Flu Outbreak in North America
Authors: Etaware Peter
Published: November 2022

America is a major hotspot for flu outbreak. The disease burden from flu infection is undermined because of its symptoms’ complexity and high level of similarity with SARS, MERS and COVID-19 infections. The epidemiology of influenza using contemporary data to develop stochastic computer algorithms capable of backcasting and forecasting seasonal trends, pattern recognition, and disease quantification, was the aim of this research.Three (3) models were developed, programmed and optimized for influenza epidemiology using contemporary data. They are ETA-REX-EMM-Flu-Vac (VS-01), ETA-REX-EMM-Flu-Epidemics (VS-02), and ETA-REX-EMM-Flu-Deaths (VS-03).The models had very high rating for disease prediction accuracy, model efficiency, and output quality (R2 = 97.70-100%, Adj.R2 = 97.60-99.90%, and Pred.R2 = 97.20-99.35%). The difference between contemporary data and simulated results were insignificant at P<0.001 [T-test = “ns”, (0%)0≠r<1.0(100%)]. It was estimated that 22.8% of US population will suffer from influenza in 2022, and a deficit of -7.1% (i.e., 15.7%) should be expected by 2050. The probability of dying from flu will reduce from 0.098% (2012) to 0.017% (2050).
Performance assessment of steel truss railway bridge with curved track
Authors: Venglár Michal , Lamperová Katarína , Sokol Milan
Published: November 2022

Non-destructive Structural Health Monitoring techniques can be incorporated into bridge integrity management by assessing structural conditions. This paper describes a performance assessment of a steel truss railway bridge in Bratislava using vibration-based techniques as a further part of maintenance in addition to standard visual inspections. To obtain the necessary data, a multipurpose measuring system was used. Various types of data were measured, e.g. accelerations, strains, and displacements. The advantage of the multipurpose measuring system was that the traffic over the bridge was not restricted, even though the bridge carries only a single curved track. Two test campaigns were conducted to assess the performance of the bridge. One campaign was devoted to measuring ambient vibrations in order to perform the operational modal analysis, and the second was carried out to measure strains and displacements during a train passage. The results show a successful system identification of the structure using ambient vibrations; and a finite element model was verified and validated by a comparison of strains and displacements, as well as by modal parameters. According to the results obtained, the structural health of the investigated bridge was satisfactory.
Film Review - Episode in the Life of An Iron Picker (2014)
Authors: Vargas Francisco
Published: November 2022

A review of Danis Tanović's Episode in the Life of An Iron Picker (2014).
Adaptación transcultural del Cyber Dating Abuse Questionnaire (CDAQ) para jóvenes mexicanos
Authors:   Cuerpo Académico Comportamiento, Salud y Calidad de Vida, México, Hidalgo-Rasmussen Carlos Alejandro ,   Centro de Investigación en Riesgos y Calidad de Vida, Universidad de Guadalajara, México, Javier-Juárez Sandra Paola ,   Centro de Investigación en Riesgos y Calidad de Vida, Universidad de Guadalajara, México, Chávez-Flores Yolanda Viridiana ,   Facultad de Ciencias de la Salud, Universidad Autónoma de Baja California, México, Zurita-Aguilar Kathia Anahí ,   Centro de Investigación en Riesgos y Calidad de Vida, Universidad de Guadalajara, México
Published: November 2022

Introducción: La violencia digital en las relaciones de pareja es un problema de salud pública que requiere de evaluaciones válidas y confiables. El objetivo de la presente investigación fue adaptar transculturalmente y evaluar las propiedades psicométricas del Cyber Dating Abuse Questionnaire (CDAQ) para jóvenes mexicanos. Método: Participaron 1158 jóvenes de 18 a 24 años, 62.9 % fueron mujeres. En la fase de verificación de la equivalencia lingüística, se adecuaron cuatro palabras de la versión original en castellano. Resultados: Se encontraron índices de ajuste aceptables en el análisis factorial confirmatorio, además se encontró validez convergente y discriminante de los factores, excepto entre los factores de victimización y perpetración de Agresión Directa. Se encontró evidencia de validez divergente con la calidad de vida y convergente con comportamientos de riesgo. La fiabilidad total fue superior a .87. Conclusiones: Los hallazgos sugieren que el CDAQ puede ser un cuestionario útil para evaluar el abuso digital en las relaciones de pareja en jóvenes mexicanos.
LEGAL POLICY ON ECO-PARTNERSHIPS TO ACHIEVE SUSTAINABLE DEVELOPMENT
Authors: Absori Absori , Bangsawan Mohammad Indra , Budiono Arief , Disemadi Hari Sutra
Published: November 2022

There is a lack of maximum realization of sustainable development in the Surakarta City Government’s partnerships. This study proposes a fishbone diagram that seeks the root causes that affect the realization of partnerships that encourage sustainable development in Surakarta. The study aimed to convey ideas on environment-based local government partnership policies (Eco-Partnerships) to achieve sustainable development. It was a descriptive, doctrinal-method legal research. The primary data was sourced from library research, and the author also carried out some field research. The research used several indicators, namely Surakarta City Government’s Partners, Regulations, and Culture as the small bones and the analysis result of the failure to realize eco-friendly partnerships as the big bone. The result of the study showed that the implementation status of 19 out of 52 regional partners and five regional partners with a focus on environmental activities had not yet been followed up by the regional government. The regulation was ineffective because the Surakarta Government lacked adequate policies on eco-partnerships. Therefore, the Surakarta City Government needed to enforce a policy based on regional regulations on partnerships that integrate economic, social, and environmental aspects (Eco-Partnership).
PENGEMBANGAN MODEL PERSEDIAAN ECONOMIC ORDER QUANTITY MULTI ITEM DENGAN MEMPERTIMBANGKAN FAKTOR KADALUARSA, ALL UNIT DISCOUNT, DAN KENDALA KAPASITAS
Authors: Silitonga Roland Y. H. , Julieta Celia Esterina
Published: November 2022

Jenis usaha produk konsumsi seperti minimarket biasanya menjual beberapa jenis produk dengan volume yang rendah dan memiliki fluktuasi permintaan yang cenderung kecil. Terdapat tiga hal yang perlu diperhatikan dalam mengendalikan persediaan pada minimarket, yaitu kemungkinan untuk mendapatkan potongan harga jika membeli bahan makanan dalam jumlah besar, barang konsumsi yang dapat kadaluarsa,, serta adanya keterbatasan kapasitas yang dimiliki. Tujuan dari penelitian ini adalah mengembangkan model persediaan economic order quantity multi item dengan mempertimbangkan faktor kadaluarsa, all unit discount, dan kendala kapasitas. Pengembangan model dilakukan dengan cara mengembangkan model persediaan economic order quantity multi item dengan mempertimbangkan kadaluarsa dan all unit discount dari model terdahulu, lalu dilanjutkan dengan mengembangkan faktor kendala kapasitas menggunakan persamaan proporsi permintaan produk. Model yang telah dikembangkan akan diuji coba dengan melakukan perubahan pada nilai parameter model untuk melihat sensitivitasnya. Dari hasil analisis sensitivitas yang telah dilakukan, ditemukan bahwa total biaya persediaan sensitif terhadap harga beli satuan barang. Sedangkan, waktu pemesanan sensitif terhadap perubahan kapasitas gudang. Abstract[Development of Economic Order Quantity Multi Item Inventory Model by Considering Perishable Factor, All Unit Discount, and Capacity Constraint] Types of consumer product businesses such as minimarkets usually sell several types of products with low volumes and tend to have small fluctuations in demand. There are three things that need to be considered in controlling inventory at minimarkets, namely the possibility of getting a discount if you buy food in bulk, consumer goods that can expire, and the limited capacity they have. The purpose of this study is to develop a multi-item economic order quantity inventory model by considering expiration factors, all unit discounts, and capacity constraints. Model development is carried out by developing a multi-item economic order quantity inventory model by considering expiration and all unit discounts from the previous model, then proceeding to develop a capacity constraint factor using the product demand proportion equation. The developed model will be tested by making changes to the model parameter values to see its sensitivity. From the results of the sensitivity analysis that has been carried out, it was found that the total cost of inventory is sensitive to the unit purchase price of goods. Meanwhile, the time of ordering is sensitive to changes in warehouse capacity.Keywords: economic order quantity; multi item; perishable; all unit discount; capacity constraint.
Program Začít spolu jako inovace měnící tvář českého školství
Authors: Poche Kargerová Jana , Seberová Alena , Váňová Krejčová Věra
Published: November 2022

Cílem diskusního příspěvku je analyticky reflektovat vývoj a zejména přínos vzdělávacího programu Začít spolu na poli inovací preprimárního a primárního vzdělávání v České republice. Záměrem je nejen popsat konkrétní kvalitativní změny, které program vnesl a vnáší do každodenní pedagogické praxe škol, ale rovněž zachytit dopady implementace programu Začít spolu na širší terén kurikulární reformy a kvality učitelské profese.
More similarities than differences: women’s and men’s perspectives on ice-hockey reporting in Czech sports journalism
Authors: Hrbáčková Anna
Published: November 2022

This study explores differences in the reporting of female and male sports journalists. Based on a brief review of the literature related to gender differences in sports journalism and the stereotypes associated with the work of female sports journalists, the paper identifies a purported ‘female writing style’ characterized by a focus on soft news, an emotional approach to reporting and reduced interest in statistical and analytical data.
Using a quantitative content analysis, I reviewed 167 audio-visual and 50 written ice-hockey reports about Czech Extraliga produced by six sports journalists, who worked in leading Czech sports media departments. I observed the frequency with which the reporters presented statistical data, evaluated a performance, described emotions, recounted personal stories, and used original phrases. Comparing women’s and men’s output, it emerged that gender of the author did not have a dominant influence on the form of their reports and did not impact the use of specific language elements.
An Empirical Research on the Relationship Between Employee Boreout and Performance: Mediating Role of Procrastination
Authors: Al-Mashadani Hadeel
Published: November 2022

The purpose of this study was to discover whether employee boreout was related to employee task performance and whether employee procrastination was mediating this relationship. In order to achieve that, a cross-sectional research has been conducted. The data were collected from 400 employees who work in a telecommunication company operating in Dubai, the United Arab Emirates, using the survey technique, between the 16th of July and the 19th of August, 2022. Linear regression tests were used to analyze the collected data. Findings showed that there was a negative relationship between the crisis of meaning and task performance, job boredom and task performance, and the crisis of growth and task performance. This study also indicated that there was a positive relationship between procrastination and the crisis of meaning, job boredom, and the crisis of growth. Finally, it was revealed for the first time that procrastination was mediating the relationship between employee boreout and task performance.
Immunology of Modern Society Humans [IMSH]
Authors: Shnawa Ibrahim M. S.
Published: November 2022

Humans lives in modern society are subjected to an array of factors that impacts the cellularity and  functionality of their immune systems. These  IMSH factors  were ensemble as; Global changes, liberal spread of mental influencing drugs, war warfare ,terrorism  ,environmental mutagens and carcinogens  as well as environmental allergens .So they are being at risk for both enhancing or dampening effects on their immune systems. Workers have been documenting four main categories of targeted  human immune system  living at risk  of modern society .The   IMSH   categories are; intravenous   drug users, intensive care patients, tumor patients ,  war warfare and terrorism. The intravenous drug users have shown increase in their humoral B cell immune responses  through the elevation of B cell counts and activities and increase in activation markers of T cell subsets. Intensive care patients were mainly  showing  functionality of cellular immunity like that of ageing immune cells. Tumor patients, however, were found expressing diversity and  compositional heterogeneity of  immune cell type reaching  33 subsets and marked functional alterations. Tumor microenvironment  have shown at least six  dominant  pan-cancer-classes of dominant  immune cells as compared to normal human subjects immune cellularity. Biological warfare and bioterrorism insults  were being accompanied  by emergence and re-emergence of unfamiliar  agent pathogenicity ,seasonality  and marked host susceptibility to the terrorism  agent necessary need for individual therapy  and management ,as well as for pre and post exposure  mass vaccination .Each IMSH category have expressed shared and distinctive features. The unified functional insight to the immune systems of human living in modern society is that formed cellular elements of these  immune systems behave to different insults in different ways and different elements reacts differently to the same insult.
Avoiding Common Conflicts of Interest in the Lawyer-Client Relationship
Authors: Hunter Richard J. , Shannon John H.
Published: November 2022

There are several areas in the law where conflicts of interest commonly occur in the context of the lawyer-client relationship. This article, which is Part II of a three-part series on issues relating to the lawyer-client relationship, will explain two of the main conflicts that may occur: simultaneous representation of clients with differing or conflicting interests and personal conflicts of interest between a lawyer and a client. In addition, the paper will discuss the special considerations inherent in contingent fee arrangements.
Death Inequality During the First Year of Life in Morocco: A Macro Level Analysis
Authors: LOUDGHIRI Khadija , BAKASS Fatima , FAZOUANE Abdesselam
Published: November 2022

Disparities in child mortality are a reality in Morocco. These disparities coexist with inequalities in: (i) the availability of primary health care (PHCs); (ii) the socioeconomic status of the population as reflected by the prevalence of various forms of poverty; as well as (iii) fertility levels (TFRs) and the status of women in literacy and employment rates. Despite its limitations, this research provides a macro-level understanding of the link between infant mortality and a range of aggregates (political, economic, social and demographic).The metadata collected in the 2014 census (RGPH-2014) RGPH-2014 was used to construct a provincial proxy indicator of infant mortality by area of residence.This is considered as a dependent variable that we have tried to explain by the above-mentioned indicators. This is considered as a dependent variable that we have tried to explain by the above-mentioned indicators. The latter indicators reflect the socio-economic conditions prevailing in each of the provinces by area of residence. In addition, they give information on the availability of basic health services and on the woman's status. A key finding is that the level of current fertility as measured by the TFR negatively affects child survival. With a statistically significant regression coefficient of 2.912 (Pvalue =0.000), it can be argued that high fertility increases the risk of infant mortality.  In turn, the prevalence of overall poverty also has a statistically significant effect on infant survival (β= -0.213 with a pvalue =0.029).
(Bio-/Cyber-/Robo-)technologically Enhanced and Designed “People” in the Most Recent Croatian Dystopian Prose
Authors: Rezo Vladimira
Published: November 2022

The following paper focuses on typification and cataloguing of the various manifestations of body decorating and enhancing in selected novels and stories, and also tries to examine their meanings, what changes they bring, what attitude of the authors towards technological progress they reveal and what social/cultural phenomena and processes they reflect. The paper also questions the upgrades of the human mind and the transformations of humans into some other forms of existence. Nine contemporary dystopian novels and five short stories have been studied for the purposes of this research. The methodological framework consists of texts that question the enhancement of the human body conducted in various ways, especially through biotechnology, bioengineering, cybernetics, robotics, etc.
PKB per capita a poziom życia mieszkańców powiatów województwa łódzkiego
Authors: Dańska-Borsiak Barbara
Published: November 2022

W prezentowanych badaniach oszacowano PKB na mieszkańca w powiatach województwa łódzkiego. Na podstawie wartości pierwszej składowej metody PCA stworzono ranking powiatów według poziomu życia, a także wyodrębniono grupy powiatów podobnych metodą k-średnich. Badanie przeprowadzono dla lat 2019 i 2020. Porównanie PKB per capita i poziomu życia pokazało, że kategorie te są skorelowane w umiarkowa- nym stopniu. W roku 2020, mimo wybuchu pandemii COVID-19, województwo łódzkie miało dodatnią, najwyższą dynamikę produktu krajowego brutto ogółem w Polsce, co przełożyło się na wyniki powiatów. Wpływ pandemii w żadnym z nich nie był szczególnie widoczny, w sensie dużych spadków PKB ani poziomu życia.
Popularność systemu roweru miejskiego w wybranych dzielnicach Poznania wobec cech środowiska zabudowanego
Authors: Doszczeczko Bartosz
Published: November 2022

Wiele miast w Polsce mierzy się z konsekwencjami wysokiego poziomu motoryzacji, takimi jak kongestia, zanieczyszczenie powietrza, hałas oraz koszty wynikające z utraty czasu na przemieszczanie się. Jednym ze sposobów na rozwiązanie tych problemów wydają się systemy rowerów miejskich zyskujące coraz większą popularność w polskich aglomeracjach. Poznański Rower Miejski został uruchomiony w 2012 r. i umożliwia przemieszczanie się pomiędzy stacjami wypożyczeń zlokalizowanymi w najważniejszych punktach miasta, bez konieczności posiadania własnego pojazdu. Celem artykułu jest analiza wybranych cech środowiska zabudowanego, które mogą wpływać na popularność korzystania z rowerów miejskich oraz identyfikacja czasowych i przestrzennych prawidłowości mobilności rowerowej.
Assessment of drought tolerance indices in faba bean genotypes under different irrigation regimes
Authors: Abdelhaleim Manal S. , Rahimi Mehdi , Okasha Salah A.
Published: November 2022

Drought stress has devastating impacts on faba bean production, particularly with the current abrupt climate changes in arid environments. Hence, it is essential to identify drought-tolerant genotypes. The present study aimed at assessing six faba bean genotypes under three irrigation levels during two winter successive growing seasons (2018/2019 and 2019/2020). The applied irrigation levels were well-watered (every 4 days (D1), moderate drought every 8 days (D2), and severe drought 12 days (D3)) regimes. The analysis of variance exhibited highly significant differences among genotypes, irrigation treatments, and their interactions for all studied traits, except the number of pods plant−1 in the first season. Yield traits of all assessed genotypes decreased significantly with increasing drought stress. Otherwise, proline content (Pro) increased significantly with increasing drought stress. The genotypes Giza.843, Nubaria.2, and Nubaria.3 recorded the highest values of plant height, number of branches/plant, pods/plant, pods weight/plant, 100 seed weight, seed yield/plant, and seed yield/kg under drought stress. Similarly, the highest Pro was displayed by Giza.843 and Nubaria.3 under drought stress in both seasons. Furthermore, Giza.843, Nubaria.2, and Nubaria.3 genotypes had the highest values for most tolerant indices. Accordingly, these genotypes could be exploited in developing drought-tolerant and high-yielding faba bean genotypes in arid environments through breeding programs.
Aquaporin-8 overexpression is involved in vascular structure and function changes in placentas of gestational diabetes mellitus patients
Authors: Shan Yanxing , Cui Jiawen , Kang Xinyi , Tang Weichun , Lu Yiling , Gao Ying , Chen Liping
Published: November 2022

To study the role and mechanism of aquaporin-8 (AQP8) in placental vascular development in gestational diabetes mellitus (GDM), hematoxylin–eosin staining and immunohistochemistry were utilized to analyze the histopathological changes in placentas in GDM patients. Transwell, CCK-8, and tube formation assays were performed to examine cell migration, proliferation, and tube formation. AQP8, vascular cell adhesion molecule 1 (VCAM-1), tumor necrosis factor alpha (TNF)-α, and vascular endothelial growth factor (VEGF)-A expression levels were investigated. Relative to the control group, the placentas in the GDM group showed morphological changes, the number of microvessels in the placental villi arterioles was significantly higher, and the area of microvessels in the arterioles of placental villi was significantly lower. The expression levels of VCAM-1, TNF-α, VEGF-A, and AQP8 in the GDM placentas and human umbilical vein endothelial cells (HUVECs) stimulated by high glucose were significantly higher than those in the control group, and AQP8 was located in placental endothelial cells. Overexpression of glucose and AQP8 inhibited tube formation, migration, and proliferation in HUVECs. High glucose levels can induce dysfunction in vascular endothelial cells and lead to pathological changes in the placental vascular structure in GDM. AQP8 overexpression in placental GDM can inhibit endothelial cell behavior, cause endothelial cell dysfunction, and further participate in the occurrence and development of GDM placental vascular lesions.
Archaeological culture, document texts, and the construction of early Wu Yue history
Authors: Xu Lianggao
Published: November 2022

The current study first systematically traces the archaeological cultures of southeast China (the Wu Yue region) during the Western Zhou, from the perspective of material culture remains, sources, regional variants, and social conditions revealed from the archaeological evidence. It then analyzes the plurality of interpretations of bronze inscriptions and the nature of documentary records concerning the emergence of the Wu and Yue states and their early history. The author points out that a regional archaeological culture with unique characteristics, showing great cultural affinity with the Wu Yue culture during the late Eastern Zhou period (771–475 BCE) had existed in southeast China during Western Zhou (1045–771 BCE). However, the emergence of Wu and Yue states and their early history recorded in historical texts have not been confirmed by any archaeological discoveries in the form of material cultures, bronze inscriptions, or documentary texts. Assertions of direct connections between related archaeological cultures and early Wu and Yue states lack persuasiveness. Considering this, the author proposes new insights into the textuality of documentary records, the relation between archaeology and historical texts, as well as the essence of historiography.
2021 年度华语研究综述
Authors: 月丽 卢
Published: November 2022

In 2021, Huayu study has been expanded and deepened at the ontology and application levels, and has achieved fruitful results. The former shows that the situation of more synchronic research and less diachronic research has improved. While the synchronic research has increased steadily, a lot of diachronic research has been added; the latter has carried out a series of researches on important topics such as Chinese teaching and Huayu planning. On the whole, the research content is more abundant, the scope is expanded, and the perspectives tend to be diversified. However, this year’s Huayu studies are still relatively weak in some aspects, such as Huayu theoretical construction and empirical research. In addition, the construction and application of Huayu corpus have begun to receive great attention, which may become the future trend of Huayu study.
“Brown hare never goes underground”: the exception that proves the rule
Authors: Pecorella Stefano , Mori Emiliano
Published: November 2022

Amongst leporids, rabbits use underground warrens as resting and reproductive sites, whereas hares usually rests in soil depressions in woodlands or scrublands, providing them with cover and protection from predators. In this short communication, we reported for the first time the use of badger burrows as resting sites of the European brown hareLepus europaeusin North-Eastern Italy. Underground dens may provide hares with the best cover from daylight and protection from both predators and bad weather conditions.