bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Biological Activity and Pharmacological Attributes of Pariploca aphylla: Potential Source of Functional Food and Nutraceuticals
Authors:   Department of Chemistry, The University of Lahore, Lahore, Pakistan, YOUNAS Umer , IQBAL Shahid ,   Department of Chemistry, Division of Science and Technology, University of Education Lahore, Pakistan, SALEEM Asif ,   Department of Botany, Kallar Kahar Science College, Kallar Kahar, Pakistan, RAHMAN Roeya ,   Department of Chemistry, The University of Lahore, Lahore, Pakistan, NAZIR Arif ,   Department of Chemistry, The University of Lahore, Lahore, Pakistan, HASSAN Faiza ,   Department of Chemistry, The University of Lahore, Lahore, Pakistan, SAJID Arfaa ,   Department of Chemistry, The University of Lahore, Lahore, Pakistan, SAEED Zohaib ,   Department of Chemistry, Government College University Lahore, Lahore, Pakistan, IQBAL Munawar ,   Department of Chemistry, Division of Science and Technology, University of Education Lahore, Pakistan
Published: May 2024

Functional foods and nutraceuticals are gaining popularity as they are being developed and commercialized with the aim of reducing the risk of various diseases and their treatment. In this study, antiradical activity guided fractionation of Pariploca aphylla (P. aphylla) crude extract was conducted. A crude methanolic extract of P. aphylla was prepared and then fractionated using different solvents, including hexane, chloroform, ethyl acetate, butanol, and water. This approach allowed for the isolation and characterization of different fractions of P. aphylla with potential antioxidant activity. These fractions were tested for the determination of total phenolic content, antiradical (DPPH• and ABTS•+) potential and HPLC quantification of phenolic acids. Among all the tested fractions, butanol fraction exhibited highest phenolic content and significant antiradical potential. Butanol faction was further sub-fractionated using a silica gel-loaded column and 18 sub-fractions were obtained. Antiradical potential of all 18 sub-fractions was determined and sub-fraction 12 was found having highest radical scavenging potential. Structures of compounds in sub-fraction 12 were identified and quantified using GC-MS. Among all the identified compounds, 7-Trimethylsilyloxytridecane (C16H36OSi) and 1,2-bis(trimethylsiloxy)ethane (C8H22O2Si2) were found in highest ratio. All of the compounds can be declared having high anti-radical potential that can be extracted or synthesized for possible exploitation as functional food or nutraceuticals.
Prenatal & Perinatal Risk Factors of Autism Spectrum Disorder
Authors: Lucky Mohsina Akter , Arefin Khondoker Ehsanul , Rahman Md Mizanur , Bhuiyan Md Elias
Published: May 2024

Background: Autism spectrum disorder (ASD) is lifelong neurodevelopmental disorder characterized by impairments in social function, communication, and certain behaviors. The etiology of ASD is unclear & it is believed to be multi-factorial, among those several prenatal & perinatal factors are found to be significant. So, the necessity of this study is to detect the presence of known risk factors of ASD which in turn may help in the early diagnosis and intervention for better long-term outcomes.
Objective: To find out prenatal and perinatal risk factors of ASD.
Method: A case control study was conducted with 112 cases of ASD and 201 controls of 2-6 years of age. The study was carried out in Center for Neurodevelopment and Autism in Children (CNAC), in the department of Paediatrics, Bangabandhu Sheikh Mujib Medical University and Autism Welfare Foundation (AWF). ASD was diagnosed by DSM-IV TR criteria. Mothers were interviewed and data were collected by semistructured questionnaires.
Results: Total 5 risk factors were identified as the risk factors of ASD. They were: advanced paternal age (OR=2.84) and maternal age (OR=1.87); male baby (OR=2.01); environmental stress during pregnancy (OR=1.61) and preterm delivery (OR=1.80).
Conclusions: It is concluded that advanced paternal age, maternal age, male baby, environmental stress during pregnancy and preterm delivery are associated with increased risk of ASD.
BANGLADESH J CHILD HEALTH 2022; VOL 46 (3) : 115-121
Augmenting CNS Tumor Surgery: The Era of Artificial Intelligence
Authors: M Afzal Hossain
Published: May 2024

Abstract not available
Bang. J Neurosurgery 2023; 12(2): 1
Comparison of Surgical Outcomes between Endoscopeassisted Evacuation and Conventional Burr Hole Aspiration of Brain Abscess at a Tertiary Care Hospital
Authors: Md Farhad Ahmed  , Md Sumon Rana  , Kanij Fatema Ishrat Zahan  , Shirazum Munira  , Md Shafiqul Islam  , Monzurul Haque
Published: May 2024

Background: Brain abscess is a major health problem with a reasonable morbidity and mortality rate.
Objective: The objective of this study was to compare the efficacy between endoscope-assisted evacuations of brain abscess with burr hole aspiration method in a tertiary health care center.
Methodology: This non-randomized clinical trial was conducted in the Department of Neurosurgery at Dhaka Medical College Hospital, Dhaka, Bangladesh during the period of July 2016 to December 2017. Patients with the age group of more than or equal to 18 years of both gender presented with brain abscess were enrolled in this study. The endoscope-assisted evacuation of abscess was done on group A patients and burr hole aspiration was done on group B patients. Outcome of the patients was assessed using GCS and MRC muscle power grading and by GOS. Patients were evaluated by contrast enhanced CT scan of head at pre-operative, 1st and 30th postoperative day. Both groups received best available medical treatment along with surgery.
Results: The mean age of was 13.0 ± 6.3 years in burr hole group and is 13.1 ± 6.4 years in endoscope-assisted group. The patients presented with GCS was 66.7% in burr hole group and 93.3% in endoscope assisted group. The study showed e”75.0% evacuation of brain abscess at 1st post-operative day in 13(92.9%) patients in endoscope-assisted group and 5(33.3%) patients in burr hole group. The study showed mortality rate of 6.7% in both the groups. Mean residual volume at 30th post operative day was 0.75ml in endoscope-assisted group and 1.75ml in burr hole aspiration group.
Conclusion: In conclusion endoscope-assisted procedure has better rate of abscess evacuation, less chance of residual and repeated surgeries than conventional burr hole.
Bang. J Neurosurgery 2023; 13(1): 14-19
Pineal Region Tumor with Ventricular Extension with Hydrocephalus Removed by Supracerebellar Infratentorial Approach in a 19-Year-Old Female: A Case Report
Authors: Sukriti Das  , Md Rokibul Islam  , Md Mahbub Hasan  , Abu Hena Mostafa  , Mohammad Abu Taher Miah  , Md Ashraful Islam  , Bibek Gaurab Singh  , Sumit Barua
Published: May 2024

Pineal region tumors are uncommon, accounting for d”1% of intracranial tumors in adults and 3–8% of pediatric brain tumors. Getting an epidermoid in pinealregion is also very rare. In 1928 Cushing was the first to report the pineal localization of the epidermoid cyst.We report a case of pineal epidermoid with ventricular extension with obstructive hydrocephalus, which was diagnosed depending on magnetic resonance imaging (MRI) findings. Knowing its benign nature, at first we planned for an Endoscopic Third Ventriculostomy and later on a gross total removal was done.
Bang. J Neurosurgery 2023; 13(1): 41-43
Thuế bảo vệ môi trường: Bằng chứng quốc tế và kinh nghiệm cho Việt Nam
Authors: Nguyễn Minh Phúc , Nguyễn Thị Mỹ Linh
Published: May 2024

Môi trường và tăng trưởng kinh tế đang là hai vấn đề chính mà các quốc gia phải đối mặt trong thế kỷ 21. Sự gia tăng nhanh chóng của nhu cầu tiêu dùng, sản xuất công nghiệp và sự phát triển kinh tế đã tạo ra áp lực lớn lên môi trường, gây ra những hậu quả đáng lo ngại như biến đổi khí hậu, ô nhiễm không khí, nước và đất đai. Để giải quyết vấn đề này, nhiều quốc gia đã áp dụng chính sách thu thuế môi trường nhằm bảo vệ môi trường cùng với việc đạt được mục tiêu trưởng kinh tế bền vững. Với mục tiêu tìm hiểu về thuế môi trường tại các quốc gia trên thế giới như Thụy Điển, Costa Rica và Thụy Điển, bài viết đề xuất hàm ý chính sách thuế môi trường cho Việt Nam. Bài học kinh nghiệm cho Việt Nam đối với thuế môi trường bao gồm việc tích hợp mục tiêu bảo vệ môi trường và trưởng kinh tế , điều chỉnh linh hoạt và thích ứng, hỗ trợ công nghệ sạch và năng lượng tái tạo, tạo cơ hội cho đổi mới và tạo việc làm, cũng như đảm bảo tính công bằng và tham gia của cộng đồng. Những bài học này giúp Việt Nam xây dựng một chính sách thuế môi trường hiệu quả và thúc đẩy sự phát triển bền vững cho đất nước.
Tác động của thuế môi trường, tăng trưởng kinh tế, phát triển tài chính đối với năng lượng tái tạo: Nghiên cứu thực nghiệm tại Việt Nam
Authors: Ngô Thái Hưng , Nguyễn Lê Quỳnh Anh , Nguyễn Thị Diễm Trang , Phạm Ngọc Hà , Vũ Hương Giang
Published: May 2024

Nghiên cứu phân tích mối quan hệ giữa thuế môi trường), tăng trưởng kinh tế, phát triển tài chính), và năng lượng tái tạo tại Việt Nam trong giai đoạn từ 2003 đến 2021 sử dụng mô hình hồi quy phân vịcùng với kiểm định nhân quả Granger trên từng phân vị. Kết quả chỉ ra rằng thuế môi trường, tăng trưởng và phát triển tài chính đều có ảnh hưởng đáng kể đến năng lượng tái tạo. Ảnh hưởng trên có thể gây ra ảnh hưởng tiêu cực hoặc tích cực đối với tiêu thụ năng lượng sạch, tùy thuộc vào bối cảnh và điều kiện cụ thể. Kết quả nghiên cứu khẳng định thuế môi trường như một chiến lược hiệu quả nhất để thúc đẩy việc sử dụng nguồn năng lượng xanh và đề xuất các chính sách cụ thể nhấn mạnh vào việc nâng cao vai trò của năng lượng tái tạo trong chiến lược phát triển về một tương lai năng lượng sạch và bền vững của Việt Nam.
Tác động của quản trị lợi nhuận đến tỷ suất sinh lời trên thị trường chứng khoán Việt Nam
Authors: Lê Hải Trung , Lê Thị Thu Hà , Bùi Thị Thuỷ
Published: May 2024

Nghiên cứu này đánh giá tác động của quản trị lợi nhuận tới tỷ suất sinh lời của 202 cổ phiếu niêm yết trên thị trường chứng khoán Việt Nam trong giai đoạn 2013-2022. Kết quả hồi quy dữ liệu dạng bảng cho thấy mức độ quản trị lợi nhuận của các doanh nghiệp có tác động ngược chiều tới tỷ suất sinh lời của cổ phiếu trong năm tiếp theo. Kết quả mô hình mở rộng cho thấy tác động này là chỉ có ý nghĩa thống kê khi các doanh nghiệp thực hiện quản trị lợi nhuận theo chiều hướng tăng lợi nhuận. Điều này thể hiện mức độ hiệu quả thấp của thị trường chứng khoán Việt Nam với mức độ minh bạch thông tin thấp, cùng với tỷ lệ lớn các nhà đầu tư cá nhân trên thị trường khiến các nhà đầu tư phản ứng quá mức với các thông tin về lợi nhuận. Trên cơ sở đó, nghiên cứu đưa ra một số khuyến nghị chính sách đối với thị trường chứng khoán.
La imposibilidad de acceder al derecho a la jubilación por deudas de los patronos. Una mirada desde el procedimiento administrativo del IESS y la sentencia No. 1024-19-JP/21
Authors: Vallejo-Quiroga Fanny
Published: May 2024

Dentro del presente artículo resaltaremos la vulneración de derechos que sufren los trabajadores cuando su empleador incumple con el pago de aportaciones al IESS pese a que se ha descontado dicho aporte al trabajador. 
Este incumplimiento por parte del empleador imposibilita al trabajador a que pueda acceder al derecho de jubilación, si bien es cierto el IESS faculta la creación de planillas excepcionales para que sea el trabajador o el empleador quien cancele lo adeudado y así pueda el trabajador acceder a la jubilación, surge una gran interrogante ¿es suficiente este acto de simple administración para respaldar los derechos del trabajador?, la respuesta que conlleva esta pregunta demuestra efectivamente que el sistema de coactiva que rige al IESS no cumple con los estándares básicos de recaudación, pues es un proceso que al no ser ágil provoca una vulneración de derechos de doble afectación pues el IESS en lugar de enfocarse en el cobro de la mora patronal al patrono se enfoca en cobrar montos adeudados que en la mayoría de los casos paga el trabajador al verse sumergido en su desesperación para poder acceder a su derecho de jubilación. 
Demostraremos que no existe cumplimiento a lo ordenado en la sentencia No. 1024-19-JP/21, pues en caso de mora patronal se impide la jubilación al trabajador.
Estrategias competitivas para exportación de uva ecuatoriana como fruta no tradicional hacía Corea del Sur.
Authors: Flores-Aguilar Paula , Capa-Tejedor Marcela
Published: May 2024

Ecuador posee una gran biodiversidad y capacidad agrícola para la producción de la uva de mesa, por otra parte, está Corea del Sur con un gran interés constante en frutas no tradicionales. El Ministerio de Producción Comercio Exterior, Inversiones y Pesca aspira que las exportaciones agroalimentarias del Ecuador incluyendo la uva de mesa, tomen presencia en el mercado de Corea del Sur, sin embargo, si un país pretende introducir su producto en un mercado desconocido y no cuenta con un plan de acción sólida, se enfrenta a diversos desafíos. El objetivo de la investigación es determinar estrategias competitivas para la exportación de uva ecuatoriana mediante estudios descriptivos y comparativos que permitan ingresar la uva de mesa como un producto no tradicional al mercado de Corea del Sur. metodología empleada fue descriptiva, de diseño experimental, se realizó un estudio de documento en donde se utilizaron datos cuantitativos y cualitativos de páginas webs que muestran estadísticas del comercio para el desarrollo internacional del país como Trade Map. En los resultados encontrados se afirma que anteriormente Corea del Sur no ha estado interesado en las frutas no tradicionales por el hecho de que no existían acuerdos o tratados con Ecuador y solo disponía del programa de intercambio de conocimientos KSP. Por ende, es que el Acuerdo Estratégico de Cooperación Económica (SECA) que se ha implementado actualmente entre los dos países, opta como una herramienta de estrategia competitiva beneficiosa para que el Ecuador pueda tomar posicionamiento en el mercado asiático.
Terapéutica para el bloqueo de la marcha en pacientes con Parkinson
Authors: Tinoco-Aguilar Noelia , Acosta-Gavilánez Roberto
Published: May 2024

La enfermedad de Parkinson es un trastorno neurológico crónico y progresivo que afecta principalmente el sistema motor, incluida la marcha. La alteración de la marcha es uno de los síntomas más incapacitantes y debilitantes para los pacientes con Parkinson. Como objetivo se pretende definir las intervenciones de la enfermedad de Parkinson abordando los enfoques tradicionales y no tradicionales para mejorar la marcha en pacientes con enfermedad de Parkinson y proporcionar recomendaciones para la práctica clínica. Se realizo una revisión narrativa de la literatura y una revisión sistemática de ensayos controlados aleatorios (ECA). Estas revisiones resumieron las intervenciones de la enfermedad de Parkinson abordando los enfoques tradicionales y no tradicionales para mejorar la marcha en pacientes con EP en los últimos 10 años, todas las búsquedas se realizaron en PubMed y Scopus y la selección del estudio fue realizada de forma independiente. Como resultados principales se obtiene que el bloqueo de la marcha es un síntoma debilitante y común en pacientes con enfermedad de Parkinson (EP), que limita significativamente su movilidad y calidad de vida. Se establecen enfoques farmacológicos, como la levodopa, y la yuxtaposición de la deferiprona que pueden mejorar temporalmente la marcha en algunos pacientes y se evidencio terapias físicas, como la fisioterapia y la estimulación cerebral profunda. Se concluye que se puede utilizar terapias neuroquirúrgicas, farmacológicas o no farmacológicas se basa en una evaluación exhaustiva de la historia clínica del paciente, la gravedad de los síntomas y los riesgos y beneficios potenciales de la intervención.
La satisfacción del cliente y su incidencia en los tiempos de entrega de productos: Caso Distribuciones JM
Authors: Romero-Valladolid Paul , Mora-Sanchez Norman , Romero-Black Wilton , Sánchez-Cabrera Liana
Published: May 2024

La investigación tiene como objetivo “determinar el grado de satisfacción de sus clientes en la distribución y entrega de productos que comercializa la empresa distribuciones JM; la metodología utilizada para el desarrollo de la investigación es descriptiva, correlacional con un enfoque cuali-cuantitativo y no experimental, apoyado por una encuesta estructurada como herramienta para la recolección de datos, tomando como referencia el modelo servqual el mismo que está compuesta por 5 variables o dimensiones y cada variable con 5 preguntas y es aplicada a los clientes de la empresa distribuciones JM; los resultados obtenidos es de satisfactorio con el 72.382% logrando que el proceso de comercialización y distribución de los productos de primera necesidad es óptimo, adecuado y el personal que lo compone es apto y competente en el desarrollo de las actividades encomendadas; además los resultados develaron la obsolescencia de su infraestructura tecnológica lo que limita el cumplimiento de las órdenes de compra y venta, así como también con el cumplimiento de los requerimientos de los clientes y los tiempos de entrega a los clientes; también los resultados develaron que a pesar de los diversos problemas que posee, mantiene la fidelidad de sus clientes esto gracias a la calidad de sus productos y la flexibilidad de los contratos de compra y venta que mantiene con sus clientes.
La calidad del servicio de telefonía móvil y la satisfacción de los usuarios de la provincia de El Oro
Authors: Armijos-Romero Jorge , Romero-Black Wilton , Mora-Sanchez Norman , Sánchez-Cabrera Liana
Published: May 2024

El servicio de telefonía móvil en Ecuador ha experimentado un crecimiento significativo durante la última década, pero así mismo atraviesa problemas graves respecto a la calidad del servicio y la satisfacción del cliente, según evidencian los registros en redes sociales y estudios académicos revisados. En tal sentido, en esta investigación del tipo descriptiva no experimental de corte transversal se planteó como objetivo comprender la calidad de los servicios de telefonía móvil, abordada desde nueve dimensiones (Llamadas telefónicas, Mensajes de texto, Datos móviles, Atención al cliente desde los call center, Atención al cliente en las agencias, Publicidad, Oferta de planes, Accesibilidad a través de locales físicos y Accesibilidad a través de medios digitales), y su incidencia en el nivel de satisfacción medido a través del Net Promoter Score (NPS), tomando como objeto de estudio una muestra de 311 personas nacidas o erradicadas por al menos cinco años en El Oro, y/o extranjeros que hayan completado el registro migratorio y estén habilitados para portar un número de teléfono celular. Los resultados evidenciaron que Claro es la operadora de telefonía móvil donde se concentra la mayor cantidad de clientes, Tuenti es donde se encuentran más satisfechos, CNT donde prefieren planes pospago, Movistar la que mejor los retiene, mientras que AkiMOVIL y MAXIplus no fueron preferidas por ninguna persona. Así mismo, se demostraron las relaciones que existen entre el género, rango etario, estado civil y el último nivel de educación aprobado, con la calidad percibida y los niveles de satisfacción.
Análisis Integral del Comportamiento Delictivo en Ecuador: Factores Críticos, Desafíos y Estrategias de Prevención
Authors: Cevallos-Rios Juan , Maldonado-Ruiz Luis
Published: May 2024

El comportamiento delictivo en Ecuador es un fenómeno multifacético influenciado por varios factores críticos, incluyendo el PIB, la pobreza por ingresos, la tasa de desempleo y el avance de la tecnología de la información. Los desafíos en la lucha contra el delito son numerosos, destacando la superpoblación, la falta de seguridad y el control del tráfico de drogas por parte de las pandillas. La presencia de estos factores y la relación existente entre ellos y el ser humano, han provocado un aumento exorbitante en los últimos años dentro del porcentaje de criminalidad y violencia en el país, factores principales, como el factor psicológico, ambiental, geográfico, sociológico y económico; Para superar estos desafíos, se requiere una mayor eficacia en el análisis criminal y un mejor análisis jurídico de la tipificación de los delitos.
Análisis de los factores que inciden en la percepción e intención de compra de los clientes de servicios bancarios en la ciudad de Machala
Authors: Romero-Araujo Axcel , Aguilar-Galvez William
Published: May 2024

Esta investigación tiene como objetivo explorar en detalle la relación entre la percepción del consumidor, su intención de compra y la lealtad hacia los servicios bancarios. A través de un análisis exhaustivo de datos y evidencia empírica, se pretende arrojar luz sobre cómo las percepciones individuales influyen en las decisiones de compra y en la construcción de relaciones de largo plazo con las instituciones bancarias. Además, se busca comprender cómo la mejora continua de los servicios bancarios puede contribuir al bienestar económico y la satisfacción de los clientes en un mundo en constante evolución.
Liderazgo remoto y su impacto en el clima organizacional en una institución financiera en la ciudad de Machala, provincia de El Oro
Authors: Frías-Maura Lorena , Muñoz-Palacio Fernando
Published: May 2024

El estudio realizado sobre el impacto del liderazgo remoto en el clima organizacional en una Institución Financiera en la ciudad de Machala, se basó en un enfoque descriptivo, observacional, no experimental, transversal y correlacional. La población comprendió a 22 empleados. Se utilizó un cuestionario distribuido en tres partes, la primera para datos generales, la segunda, con 30 ítems para la variable liderazgo remoto y la 3era parte con 40 ítems para el clima organizacional. Los resultados mostraron que  que la mayoría de los empleados eran mujeres en el área operativa (91%). En  cuanto al liderazgo remoto, los empleados mostraron una alta satisfacción, especialmente en las dimensiones de liderazgo (77.27%), compromiso (59.09%), competencias (59.09%), y habilidades e-sociales y de comunicación (77.27%). Sin embargo, aspectos como la motivación, las condiciones de trabajo, la solución de conflictos y el trabajo en equipo presentaron áreas de mejora en el clima organizacional, con un (4,55%). Se encontró una relación positiva y significativa entre el liderazgo remoto y el clima organizacional,  con un Rho de Spearman de 0,869 (IC 95% y p <0,001), lo que sugiere que un liderazgo remoto efectivo puede contribuir a un clima organizacional más favorable en la institución financiera estudiada
Aportes del modelo de gestión pública basada en los principios de la gobernanza institucional. Caso De Estudio: Dirección de Agua Potable y Alcantarillado del GAD Montecristi
Authors: Napa-Plúa Gabriela , Espinoza-Gálvez Eduardo
Published: May 2024

La investigación se centró en analizar el modelo de Gestión Pública empleada por el GAD de Montecristi mediante la dirección de agua potable y alcantarillado, para ello se midió la percepción y satisfacción ciudadana respecto a los servicios de agua y alcantarillado, destacando la calidad, continuidad y accesibilidad como ejes principales, también se buscó identificar áreas de mejora en la gestión pública considerando factores técnicos, administrativos, socioeconómicos y ambientales. La metodología empleada incluyó análisis de encuestas y entrevistas, procesadas estadísticamente, para obtener una imagen clara de la situación actual. Los resultados mostraron una percepción negativa de la calidad del agua y se evidenció desafíos en cuanto a la continuidad del servicio y la equidad en la accesibilidad. Las conclusiones apuntaron a la necesidad de una gestión más efectiva y de infraestructuras mejoradas para afrontar la demanda y las expectativas de los ciudadanos. La investigación sugirió la creación de una empresa pública de agua y alcantarillado como clave de recomendación, proponiendo un modelo de gestión que centralice operaciones, optimice recursos y mejore la respuesta a las necesidades locales. Este cambio apunta a una gestión por resultados y gestión participativa, incrementando la eficiencia y la implicación comunitaria en la toma de decisiones, y promoviendo la sostenibilidad y la profesionalización del servicio.
Análisis del impacto en la implementación de modelos de marketing digital en el emprendimiento de postres “Sugar Tasty” en el cantón Valencia
Authors: Moreno-Chapiliquin Taily , Barba-Garrido María
Published: May 2024

Este trabajo analiza la implementación de modelos de embudo de marketing digital en el emprendimiento de postres "Sugar Tasty" en Valencia, Ecuador. El objetivo es determinar el modelo más adecuado para impulsar las ventas mediante estrategias digitales efectivas. Se evaluaron los modelos AIDA y TOFU-MOFU-BOFU a través de una investigación cuantitativa no experimental, con enfoque transversal. Se realizó un cuestionario a 10 clientes. Los resultados revelaron que Instagram y Facebook son las redes sociales preferidas para buscar postres, con alta confianza en influencers y testimonios. Los clientes desean recibir promociones, muestras gratis y proporcionar datos para más información. Se concluye que el modelo AIDA es el más conveniente, al adaptarse a las preferencias identificadas y permitir una conexión efectiva mediante estrategias en redes sociales, colaboraciones con influencers y resaltar testimonios para captar atención, generar interés, despertar deseo y facilitar la compra. Se recomienda implementar el embudo AIDA, enfocado en Instagram y Facebook, aprovechando influencers y clientes satisfechos
The Impact of A Computerized Educational Program in Learning the Skill of the Accuracy of the Rectal Transmitter in Land Tennis for 10 Years Ages
Authors: Rabeea Mohammed , Sadiq Anaam Jafaar , Krook Tamara Sabah
Published: May 2024

The purpose of this paper is to lies in determining the impact of the computerized educational instructions in learning the skill of accurate straight serve in ground tennis for students aged 10 years. The use of a computerized educational program is one of the important things used to improve the level of performance in learning skills faster among students. The use of advanced equipment also contributes to making the educational process interesting and attracting learners to exercises in a pleasant and exciting way. The use of this computerized educational method also has an effective impact on scientific research because the world is now considered developed and fast, and keeping pace with development puts us at the global level. If you do not keep pace with development, learners will not obtain high-quality results. In addition, a heartbeat, it will put them at the bottom of the rankings, especially since the target age group in the research is students. Their use of advanced educational devices and programs will have a positive impact during their academic subjects. The sample of the current study was a group of students from Al-Jawahiri Primary School. The researchers have employed the experimental method via specifying the experimental and control groups with after and before tests. The research sample was divided into (7) students for each group, and the computerized educational program was conducted on the research sample. The researchers concluded that the outcomes of the experimental group have been better than the results of the "control group".
Perspectivas futuras em terapias moduladoras para Fibrose Cística: Avanços e desafios
Authors: Santos Luiz Henrique Cunha dos , Couto Victoria Carolyna Silva , Sobral Letícia Ohana Ferreira , Sampaio Julia Cartaxo Ramos , Cavalcanti Maria Gerliane Rodrigues Fonseca , Rufino Antunnes Fama , Pires Larissa di Paula Souza , Moraes Thalia Almeida de , Góes Bruno Oliveira , Soares Eduardo Antunes Oliveira Cavalcanti
Published: May 2024

A fibrose cística (FC) é uma doença genética autossômica recessiva complexa e progressiva, causada por mutações no gene CFTR, que afeta múltiplos sistemas do corpo humano, principalmente o pulmonar e o digestivo. Este artigo tem como objetivo revisar as terapias atuais e os desafios enfrentados no tratamento da FC, com foco nas terapias moduladoras do CFTR. Foi realizada uma revisão da literatura científica disponível sobre o tema, incluindo artigos de revistas especializadas, estudos clínicos, e revisões sistemáticas, dos últimos 10 anos. Foram selecionados estudos que abordam as terapias atuais, os mecanismos de ação das terapias moduladoras do CFTR, os desafios no tratamento e as perspectivas futuras. Os dados foram analisados e sintetizados para fornecer uma visão abrangente do estado atual e das direções futuras na área do tratamento da fibrose cística.
Complicações da endometriose intestinal infiltrativa profunda
Authors: Bandeira Carolina , Costa Filho Anibal , Maia Ana Cecília , Azevedo Larissa Karen Silva Alves de , Ferreira Maria Beatriz Batista , Gomes Naftali Duarte do Bonfim , Medeiros Camila Soares Barros Fernandes , Melo Thalya da Nóbrega
Published: May 2024

Introdução: A endometriose infiltrativa profunda (EIP) corresponde a uma das manifestações mais graves da doença, chegando a afetar o intestino em vinte e cinco por cento dos casos. As lesões podem se apresentar como únicas ou multifocais e os sintomas são bem diversificados. Objetivo: O objetivo do presente artigo é demonstrar as principais complicações ocasionadas pela endometriose intestinal infiltrativa profunda. Metodologia: A pesquisa encontra-se fundamentada em uma minuciosa revisão de literatura embasada em artigos minimamente selecionados, levando em consideração os critérios de relevância e atualidade, presentes em bancos de dados científicos. Resultados: Os principais sintomas evidenciados em pacientes com EIP são: dismenorreia, dor pélvica, dispareunia profunda, além de sintomas intestinais, como: diarreia, tenesmo, hematoquezia e constipação. As complicações mais críticas evidenciadas variam de acordo com a extensão da lesão. A região mais frequentemente afetada é o retossigmoide, seguido do apêndice, ceco e intestino delgado. Outras importantes complicações evidenciadas são a constipação intestinal (ocasionada pela progressão lenta das fezes através do cólon e reto) e a infertilidade. Conclusão: Embora complexas e inúmeras sejam as complicações da EIP, algumas técnicas e manejos cirúrgicos podem ser adotados para o controle tanto dos sintomas, quanto das intercorrências, buscando devolver qualidade de vida às pacientes.
Improving quality of survival after childhood cancer by developing, implementing and evaluating care
Authors:   , Grootendorst Rebecca Josephine
Published: May 2024

Survival after childhood cancer has improved significantly over the past decades. Unfortunately, many survivors of childhood cancer experience late effects due to their disease or treatment. It is important to prevent late effects, where possible, or to detect and treat them as early as possible. The PhD thesis “Improving quality of survival after childhood cancer by developing, implementing and evaluating care” consists of three parts, aiming to improve the quality of care and survival in pediatric oncology.

Part one describes the PanCareFollowUp project, a European collaboration led by the Princess Máxima Center for pediatric oncology. The PanCareFollowUp Care Intervention is a person-centered model for long-term care that can be flexibly implemented in different care settings. The PanCareFollowUp Recommendations describe which survivors are at risk of which late effects and present appropriate surveillance strategies. The PanCareFollowUp Care Study describes the outcomes of implementing the PanCareFollowUp Care Intervention in four European countries.

Part two focuses on the potential pulmonary toxic effects of cyclophosphamide. In a national LATER study including more than 800 survivors we concluded that cyclophosphamide does not cause clinically relevant pulmonary dysfunction.

Part three highlights the importance of evaluation of care. In collaboration with 400 international experts and survivors, we developed the International Childhood Cancer Core Outcome Set. Using 24 physical, psychosocial and neurocognitive outcomes, the Princess Máxima Center and other hospitals can measure their progress in improving quality of survival and benchmark their outcomes with each other.
THE EFFECT OF ABC RUNNING AND CIRCUIT TRAINNING ON INCREASING 100M SPRINT RUN ACHIEVEMENT ON AMTC PANGALENGAN ATHLETICS
Authors: Sirumapea Jefriagustinus Marulitua
Published: May 2024

Every sprint athlete is required to have excellent anaerobic ability, because anaerobic is one of the most important components in athletics, especially short running numbers such as the 100m-200m-400m number, according to the facts in the field, it was found that their 100m running performance was still low. looks quite low which can be seen from the lack of technique, strength and speed when doing the 100m run, such as when the athlete does the 100m run the leg position is still not lifted and the frequency of the foot is still not fast, the athlete's hand position is also still less attractive or less long. when swinging and the body position is too straight so that during the exercise the athlete cannot get a good time. In the process of solving this research problem, the researcher used a quasi-experimental method with a two-group pretest-posttest design. According to Endang Mulyatiningsih (2013: 96) this two-group pretest-posttest experimental design has 2 data from the measurement results, namely pretest (O1) and posttest (O2). The data analysis technique chosen is of course the two sample t-test. Only one hypothesis was tested, namely there was a difference between the mean pretest and posttest mean values. This two-group pretest-posttest research design compares the two methods of ABC Running and Circuit Training. The sample used in this study was AMTC Pangalengan which was taken randomly as many as 40 samples from 80 samples, after getting the sample the researchers divided into 2 groups, each group consisting of 20 samples, from each group given ABC Running and Circuit Training Tritmen. A did the ABC Running Exercise treatment and for group B did the Circuit Training Exercise, after each group was given the treatment it was found that the ABC Running Exercise method had a very significant effect than the Circuit Trainning Exercise method on Sprint running performance.
Perilaku Spasial Penduduk Kecamatan Setiabudi Dalam Memilih Lokasi Belanja Kebutuhan Primer
Authors: Maulana Irfan
Published: May 2024

Kecamatan Setiabudi merupakan lokasi yang memiliki dominasi pasar di wilayah Jakarta Selatan. Berdasarkan mutu kelas pelayanannya pasar terbagi menjadi dua yaitu pasar tradisional dan pasar modern. Setiap penduduk memiliki perilaku masing-masing dalam mengambil sebuah keputusan, salah satunya keputusan untuk memilih lokasi belanja kebutuhan primernya. Kebutuhan primer di dalam penelitian ini dibedakan menjadi dua yaitu kebutuhan primer pangan dan kebutuhan primer sandang. Penelitian ini bertujuan untuk menganalisis perilaku spasial penduduk Kecamatan Setiabudi dalam memilih lokasi belanja kebutuhan primer berdasarkan karakteristik perilaku penduduk (kognitif, afektif, konatif) dan karakteristik lokasi belanja. Penelitian ini menggunakan teknik pengumpulan data wawancara secara mendalam dengan informan. Analisis yang digunakan dalam penelitian ini yaitu analisis spasial dan analisis kualitatif. Hasil dalam penelitian ini menunjukkan bahwa sebagian besar penduduk dalam berbelanja kebutuhan primer pangan cenderung lebih memilih lokasi belanja pada pasar tradisional karena faktor afektif yang dirasa dekat dengan tempat tinggal atau kantor. Berbeda halnya dalam berbelanja kebutuhan sandang, penduduk cenderung memilih lokasi belanja pada pasar modern karena faktor afektif yang merasa cocok dengan pilihan serta kualitas pakaian pada lokasi belanja tujuan.
Pengembangan LKPD berbasis project based learning untuk meningkatkan pemahaman konsep matematika siswa kelas VIII SMPN 6 Seluma
Authors: Nurcahyati Sari Azni , Haji Saleh , Agustinsa Ringki
Published: May 2024

Penelitian memiliki tujuan untuk menghasilkan pengembangan LKPD berbasis Project Based Learning untuk meningkatkan pemahaman konsep matematis siswa pada materi Statistika kelas VIII SMPN 6 Seluma yang praktis, efektif, maupun valid. Penelitian ini adalah penelitian pengembangan dengan mempergunakan model pengembangan 4D yang terdiri atas 4 tahap, yakni pendefinisian, perancangan, pengembangan, penyebaran. Alat ukur penelitian membuktikan pengembangan LKPD berbasis PjBL masuk kategori: (1) Sangat Valid, memperoleh rerata skor validasi 4,64 masuk kategori sangat valid dan hasil uji reliabilitas antar validator menggunakan skor ICC sebesar 0,998 dengan kategori sangat baik; (2) Sangat Praktis dengan skor rerata kepraktisan oleh siswa dan guru sebesar 4,55; (3) Efektif dari perolehan skor N-Gain 0,7676 masuk kategori tinggi serta ketuntasan belajar siswa secara klasikal mencapai 86,2%. Berlandaskan hasil penelitian yang dilaksanakan, peneliti merekomendasikan untuk menggunakan LKPD berbasis PjBL dalam kegiatan pembelajaran karena LKPD berbasis PjBL efektif untuk meningkatkan pemahaman konsep matematis maupun hasil belajar siswa.
Especies forestales maderables y su utilidad en biotecnología y medicina
Authors:   Universidad Técnica de Ambato, Cruz Vasquez Josue David , Altamirano Chérrez Edgar Ricardo ,   Universidad Técnica de Ambato, Villegas Freire Cristina Nataly ,   Escuela Superior Politécnica del Chimborazo, Núñez Villacis Lorena de los Ángeles ,   Universidad Técnica de Ambato
Published: May 2024

Las especies forestales maderables se utilizan para obtener madera, sin embargo, estas especies poseen elementos y características que pueden aprovecharse en otros ámbitos tecnológicos. El objetivo del presente artículo fue recopilar ejemplos de especies forestales maderables cuyos componentes pueden aprovecharse en el campo biotecnológico y biomédico. Para ello se realizó una revisión de la literatura sobre estudios que describen especies forestales maderables para la obtención de productos ‘tradicionales’. Igualmente, se analizaron estudios sobre especies maderables y sus aplicaciones ‘no tradicionales’ en el campo biotecnológico, así como estudios relacionados al conocimiento ancestral y científico sobre sus aplicaciones terapéuticas. En base al análisis de la información se identificó que en el campo biotecnológico las principales aplicaciones de las especies forestales maderables son el aprovechamiento de residuos, producción de nanomateriales, biorremediación y control biológico de plagas. Los árboles y plantas son el almacén de un sin número de compuestos bioactivos y desde hace miles de años se aplican en medicina tradicional y moderna. Se corroboró que las especies forestales maderables a lo largo de la historia han desempeñado un rol crucial en la salud humana y que actualmente, varios estudios describen la relevancia de las especies forestales maderables en el biodescubrimiento y en el avance de la industria farmacéutica. En conclusión, la importancia de las especies forestales maderables va más allá de la obtención de madera por lo que es relevante el estudio continuo y de forma sostenible de sus componentes bioactivos para el desarrollo de más productos biotecnológicos y biomédicos que beneficien a la humanidad.
DOXA ETIK KESENJANGAN PERSONALIA HABITUS MAHASISWA AKUNTANSI
Authors: Alfia Yulis Diana , Kwarto Febrian
Published: May 2024

Penelitian ini bertujuan untuk mengeksplorasi doxa kesenjangan personalia dalam habitus mahasiswa penempuh Mata Kuliah Etika Bisnis dan Profesi. Strukturalis Generatif Freirien digunakan sebagai basis eksplorasi metodologis dengan menggunakan metode Freirien Coding Analysis. Strukturalisme generatif Bourdieu merupakan grand theory yang bersifat generik yang merekonsiliasi dualism dalam pandangan keilmuan modern yang single vision. Perspektif sosiologi Bourdieu mempelajari hubungan struktur – agen dan mengakomodasi bagaimana sistem kekuasaan kapital berinteraksi dengan kemampuan agen untuk berdiam sekaligus melepaskan diri dari doxa habitus dalam field. Sehingga, pola Freirien merupakan pola pedagogis yang tepat dalam mengeksplorasi doxa dalam kerangka pendidikan dialogis, yang tujuan utamanya adalah untuk memahami dan selanjutnya membebaskan habitus dari doxa sistem kuasa kapital yang disharmoni. Berdasarkan Freirien Coding Analysis, ditemukan dua doxa etik habitus, yaitu The beauty of capital domination dan the power of knowledge reification. Dua aspek kesadaran (doxa) yang dimiliki habitus ini memiliki potensi yang dapat mendorong terjadinya kesenjangan (personalia). Melalui pemahaman ini, diharapkan pendidik dapat menemukan point kritis yang diperlukan untuk melakukan perubahan, dimana perubahan pada hal dasar sangat diperlukan. Pendidikan akuntansi sudah seharusnya memiliki peran yang mengorientasikan proses edukasi pedagogis pada terjadinya perubahan (agent of change) dan kemaslahatan sosial. Proses pendidikan harus berorientasi pada kepentingan sosial dan berorientasi pada longlife education.
An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients
Authors: Scanu Matteo , Toto Francesca , Petito Valentina , Masi Letizia , Fidaleo Marco , Puca Pierluigi , Baldelli Valerio , Reddel Sofia , Vernocchi Pamela , Pani Giovambattista , Putignani Lorenza , Scaldaferri Franco , Del Chierico Federica
Published: May 2024

Background

Ulcerative colitis (UC) is a multifactorial chronic inflammatory bowel disease (IBD) that affects the large intestine with superficial mucosal inflammation. A dysbiotic gut microbial profile has been associated with UC. Our study aimed to characterize the UC gut bacterial, fungal, and metabolic fingerprints by omic approaches.

Methods

The 16S rRNA- and ITS2-based metataxonomics and gas chromatography–mass spectrometry/solid phase microextraction (GC–MS/SPME) metabolomic analysis were performed on stool samples of 53 UC patients and 37 healthy subjects (CTRL). Univariate and multivariate approaches were applied to separated and integrated omic data, to define microbiota, mycobiota, and metabolic signatures in UC. The interaction between gut bacteria and fungi was investigated by network analysis.

Results

In the UC cohort, we reported the increase of Streptococcus, Bifidobacterium, Enterobacteriaceae, TM7-3, Granulicatella, Peptostreptococcus, Lactobacillus, Veillonella, Enterococcus, Peptoniphilus, Gemellaceae, and phenylethyl alcohol; and we also reported the decrease of Akkermansia; Ruminococcaceae; Ruminococcus; Gemmiger; Methanobrevibacter; Oscillospira; Coprococus; Christensenellaceae; Clavispora; Vishniacozyma; Quambalaria; hexadecane; cyclopentadecane; 5-hepten-2-ol, 6 methyl; 3-carene; caryophyllene; p-Cresol; 2-butenal; indole, 3-methyl-; 6-methyl-3,5-heptadiene-2-one; 5-octadecene; and 5-hepten-2-one, 6 methyl. The integration of the multi-omic data confirmed the presence of a distinctive bacterial, fungal, and metabolic fingerprint in UC gut microbiota. Moreover, the network analysis highlighted bacterial and fungal synergistic and/or divergent interkingdom interactions.

Conclusion

In this study, we identified intestinal bacterial, fungal, and metabolic UC-associated biomarkers. Furthermore, evidence on the relationships between bacterial and fungal ecosystems provides a comprehensive perspective on intestinal dysbiosis and ecological interactions between microorganisms in the framework of UC.
Clinical application value of metagenome next-generation sequencing in pulmonary diffuse exudative lesions: a retrospective study
Authors: Wu Yisong , Wu Jian , Xu Nengluan , Lin Ming , Yue Wenxiang , Chen Yusheng , Zhang Qiongyao , Li Hongru
Published: May 2024

Objective

This study aims to investigate the clinical application value of Metagenome Next-Generation Sequencing (mNGS) for pulmonary diffuse exudative lesions.

Methods

From January 1, 2014, to November 31, 2021, 136 cases with chest radiologic presentations of pulmonary diffuse exudative lesions admitted to Fujian Provincial Hospital were included in the study; of those, 77 patients underwent mNGS pathogen detection. Based on the pathogen detection outcomes and clinical diagnoses, patients were categorized into an infection group (IG) and a non-infection group (NIG). A comparison was made between the diagnostic efficacy of the mNGS technique and traditional culture methods. Meanwhile, 59 patients clinically identified as having infectious pulmonary diffuse exudative lesions but who did not receive mNGS testing were designated as the non-NGS infection group (non-IG). A retrospective cohort study was conducted on patients in both the IG and non-IG, with a 30-day all-cause mortality endpoint used for follow-up.

Outcomes

When compared to conventional culture methods, mNGS demonstrated an approximate 35% increase in sensitivity (80.0% vs 45.5%, P<0.001), without significant disparity in specificity (77.3% vs 95.5%, P=0.185). Under antibiotic exposure, the positivity rate detected by mNGS was notably higher than that by traditional culture methods, indicating that mNGS is less affected by exposure to antibiotics (P<0.05). Within 30 days, the all-cause mortality rate for patients in the IG versus the non-IG was 14.55% and 37.29%, respectively (P<0.05). Following a COX regression analysis to adjust for confounding factors, the analysis revealed that a CURB-65 score ≥3 points (HR=3.348, P=0.001) and existing cardiovascular disease (HR=2.473, P=0.026) were independent risk factors for these patients. Conversely, mNGS testing (HR=0.368, P=0.017) proved to be an independent protective factor.

Conclusion

mNGS technology makes it easier to pinpoint the cause of pulmonary diffuse infectious exudative lesions without much interference from antibiotics, helping doctors spot and diagnose these issues early on, thereby playing a key role in helping them decide the best treatment approach for patients. Such conclusions may have a bias, as the performance of traditional methods might be underestimated due to the absence of complete results from other conventional diagnostic techniques like serological testing and PCR.
The landlocked ocean: landlocked states in BBNJ negotiations and the impact of fixed land-sea relations in global ocean governance
Authors: Sebuliba Solomon
Published: May 2024

This article examines the multifaceted dimensions of landlockedness within the realm of international discourse, with a particular focus on its implications for managing global commons. Drawing from socio-legal literature and auto-ethnographic experiences during the recent intergovernmental negotiations for the BBNJ agreement under the 1982 Law of the Sea (UNCLOS) as a case study, the paper prompts essential inquiries into the true essence of being landlocked in the face of global environmental challenges. Beyond traditional geographical definitions, the paper reveals the dynamic nature of landlockedness and underscores the intricate interplay of social, economic, cultural, geographical, and political factors in determining who has access to ocean space and resources and who does not. It emphasizes that landlockedness is not a static legal or physical characteristic but an ongoing process shaped by historical and political constructs. Expanding beyond the national level, the article illustrates how individuals, whether coastal or inland, experience isolation from the ocean, influencing their interactions with, perceptions of, and regulatory proposals for the ocean. This approach illuminates existing paradigms in the access, use, and management of space and resources. In conclusion, the article advocates for more inclusive and adaptable approaches in international policy debates. It calls for a departure from rigid classifications, urging for upholding collective action, recognising the intricate connections between geography, politics, law, and the environment.