bluuebunny/crossref_metadata_2025 huggingface dataset:
Соціально-психологічна проблематика дитинства в умовах війни: виклики і відповіді
Authors: Sliusarevskyi Mykola
Published: January 2023

Актуальність статті зумовлена гостротою викликів соціально-психологічному станові українського суспільства, які потягло за собою повномасштабне російське вторгнення. Найбільш вразливою до ризиків воєнного часу суспільною групою при цьому є діти. Тому виклики їхньому психологічному благополуччю та розвитку потребують спеціальних заходів реагування з боку психологічного співтовариства, органів управління освітою та освітянської спільноти в цілому. Саме на цьому наголошувалось у резонансному виступі автора на серпневій (2022 року) конференції Національної академії педагогічних наук України “Учені НАПН України – українським учителям”, який покладено в основу статті.

Мета статті полягає в тому, щоб на основі класифікації викликів психологічному благополуччю та розвитку дитини, породжених повномасштабним російським вторгненням, запропонувати комплекс заходів психологічної підтримки українських дітей в умовах війни та повоєнного відновлення країни.

Методологія. Емпіричний базис статті склали дані наукових досліджень, зокрема репрезентативних усеукраїнських опитувань, проведених Інститутом соціальної та політичної психології НАПН України від початку російсько-української війни та в період пандемії COVID-19. Здійснено вторинний аналіз та узагальнення цих даних під кутом зору сформульованої вище мети.

Результати. Виокремлено первинні і вторинні виклики психологічному благополуччю та розвитку дитини в умовах повномасштабного вторгнення. Як первинні трактуються виклики, зумовлені безпосереднім фізичним впливом війни або сприйняттям її інформаційного образу, як вторинні – ті, що мають переважно соціальне походження, спричинюються розривом та/або деформацією комунікативного поля дитини, порушенням усталених умов функціонування і розвитку. Показано, що вторинні виклики, які накладаються на первинні або додаються до них, можуть справляти на дитину не менший, а часом і більший дестабілізуючий вплив.

Практична значущість статті вбачається в запропонованому комплексі психологічно обґрунтованих заходів загального і спеціального плану, що розглядаються як відповідь на породжені війною психологічні виклики дитинству. Заходи загального плану передбачають підвищення рівня психологічної компетентності педагогів і батьків, адаптацію освітніх програм і методик до можливих когнітивних та психоемоційних наслідків травми і посттравми у дітей різного віку, кардинальне збільшення частки синхронних форм навчання в межах дистанційної освіти тощо. Під спеціальними заходами мається на увазі побудова професійної вертикалі для надання українським дітям психологічної підтримки. Описано пропоновану організаційну структуру і функції Національної системи психологічної підтримки дітей в умовах війни та повоєнного відновлення України.
Teaching and learning online through performing arts: Puppetry as a pedagogical tool in higher education
Authors: Kloetzer Laure , Tau Ramiro
Published: January 2023

Due to the coronavirus disease 2019 (COVID-19) pandemic, a Swiss university course called “Psychology and Migration” had to move online over the Spring semester 2021. In this course, Psychology and Education students learn about the sociocultural considerations of migration, through a theoretical, personal and artistic exploration of the subjective experience of migration, based on performing arts. As part of the main pedagogical strategies, students are invited to collectively create a short theatre play based on some selected literary texts. Under the conditions imposed by the pandemic, puppetry arts were chosen as a new tool for distance-learning. Collaborating with theatre professionals, the students created a short play, and performed it online using sock puppets, image theatre or object theatre. Using data collected during the course (video recordings of online sessions and students’ diaries), this article explores the critical process of reduction and expansion, and the (potentially) productive tensions that the course creates. It analyses two main appropriation modes for course students: in adaptative appropriation, students aim to reduce these tensions by adapting to the perceived expectations of teachers; in transformative appropriation, students creatively use possibilities offered by the course to conduct a personal exploration, integrating theories with their own experiences and questions.
Teaching tool codified gestures - Can more people learn more?
Authors: Janzen Ulbricht Natasha
Published: January 2023

During spring of the academic year 2020-2021, the English Didactics department of the Freie Universität Berlin offered a seminar on drama pedagogy. Given the pandemic and a syllabus which promised future teachers ‘teaching through actual classroom practice’ it was decided to take the in-person sessions between university students and grade six students online. The result of these collaborative drama lab sessions were Earth Speakr messages which, after being practiced online, were recorded in person at school in the Earth Speakr app by the English teacher, a university student assistant and the course instructor. Once uploaded, these messages become part of the global Earth Speakr artwork initiated by the artist and climate activist Olafur Eliasson. This article lays out some of the parameters, contexts and challenges of the sessions. These are complemented by individual reflections as well as outstanding questions for further research. Linguistic actions used in performative teaching, such as acting during an online guessing game or using gestures to practice pronouncing a word can have transformative effects. Even during pandemic times, there is evidence that these experiences can help learners and teachers to connect and find their own place in the social worlds they move in.
Conquering the Zoombies
Authors: Göksel Eva , Abraham Nicola
Published: January 2023

In this piece we offer a reflexive account of our recent experiences of teaching with drama in two different online settings. Eva will recount her practice teaching trainee teachers in Switzerland and Nicky will recall her practice working with postgraduate applied theatre students in a drama school in the UK. Over and over again, we have encountered the mind-set that teaching drama online is “not possible”, or at the very least, that it is but a pale reflection of face-to-face teaching. Although we were out of our comfort zone at first, we now feel that teaching with drama online has its place in our fast-paced and increasingly technological world. Teaching and learning in digital contexts will likely remain a reality from now on, thus it is the purpose of this article to make the case for the creative potential of and indeed urgent need for online teaching that includes drama.
The form and meaning: When English language teachers learn to teach through drama
Authors: Ding Li
Published: January 2023

This article investigates the challenges teachers experience while learning to teach English through drama in an action research project. Through closely examining the fundamental causes, it discerns the knowledge constituents crucial for successful learning and implementation of drama for English teaching. Difficulties are identified from three aspects: text selection and interpretation, translation into drama activities, and classroom implementation. Referring to Shulman’s teacher knowledge construct (1986, 1987), the author argues that drama pedagogy for English teaching demands a changed perspective on language regarding its form and meaning and also on drama as both subject and pedagogy. Only then can teachers effectively link language and drama and create a meaningful learning experience.
İki Dilli Çocukların Yaşadığı Bölgelerde Çalışan İlkokul Öğretmenlerinin Karşılaştıkları Zorluklar ve Buna Dair Çözüm Önerileri
Authors: Düzen Nurullah , Memduhoğlu Hasan Basri
Published: January 2023

Bu araştırmanın amacı, iki dilli çocukların yaşadığı bölgelerde çalışan ilkokul öğretmenlerinin alanda karşılaştıkları zorluklar ve bu zorluklara ilişkin çözüm önerilerini belirlemektir. Bu amaç doğrultusunda araştırmanın çalışma grubunu iki dilli bölgelerde çalışan 30 sınıf öğretmeni oluşturmaktadır. Araştırma kapsamında bir nitel araştırma yöntemi olan fenomenolojiden yararlanılmış, araştırmanın verileri ise yarı yapılandırılmış görüşme yoluyla elde edilmiştir. Araştırma verilerinin analizinde içerik analizi kullanılmıştır. Araştırma sonuçlarına göre, iki dilli çocukların yaşadıkları dil farklılığının çocukların akademik başarısını olumsuz etkilediği ve iki dilli bölgelerde çalışan öğretmenlerin çocukların dilini bilmesinin öğretmene avantaj sağladığı sonucuna ulaşılmıştır. Ayrıca öğretmenlerin velilerle yaşadıkları dil probleminin öğretmen-veli iş birliğini olumsuz etkilediği ve bu iletişim probleminin de çocuğu olumsuz etkilediği görülmüştür. Öğretmenler, çocuğun birinci dilinde desteklenmesi ve okul öncesi eğitimin bu bölgelerde zorunlu olması gerektiğini çözüm önerileri olarak sunmuşlardır.
Un pequeño libro para un gran paso: Del paradigma de la enseñanza al paradigma del aprendizaje
Authors:   Universidad del Azuay, Guillén-García Gabriela
Published: January 2023

Ser profesor, en cualquier nivel de formación, resulta un trabajo de gran responsabilidad. No estamos llamados a transmitir únicamente conocimientos ni información, estamos llamados a formar ciudadanos que transformen los espacios donde se desenvuelven. Y es que ser profesor es, como su nombre lo indica, pro- fesar una vocación que nos lleva a mejorar las condiciones de nuestros estudiantes y del mundo al que servirán cuando salgan de nuestras aulas. Así que, asumiendo este gran reto, debemos conocer también que nuestra vocación puede mejorarse, podemos formarnos en el arte de ser profesor. Es muy común pensar que el tener un título profesional, en cualquier campo, nos habilita directamente como docentes; pero, aunque este es un primer paso, no necesariamente garantiza que seamos buenos profesores. La docencia es un arte para el que podemos prepararnos y en el que podemos utilizar estrategias que faciliten el proceso de enseñanza-aprendizaje. Otro factor que nos lleva a prepararnos para ejercer la docencia en nuestros días es el hecho de que las exigencias de la sociedad han cambiado; hemos pasado de una sociedad industrial en la que necesitábamos formar a nuestros estudiantes para que pudieran ejercer con eficacia roles dentro de los diversos procesos industriales a una sociedad del conocimiento una sociedad que cambia rápidamente y en la que no podemos tener certeza de que el conocimiento enseñado hoy pueda ser útil el día de mañana. Así, el papel del docente ha cambiado desde la transmisión de información y conocimiento hacia un papel de docente guía que genera en sus estudiantes la capacidad de buscar, acceder y discriminar la información. 59 páginas e-ISBN: 978-9942-822-24-6
Bitácora: Tripulación de ilustradores
Authors:   Universidad del Azuay, Ochoa Diego , Estrella-Toral Rafael ,   Universidad del Azuay, Tripaldi-Proaño Toa ,   Universidad del Azuay, Alvarracín-Espinoza Cristian ,   Universidad del Azuay
Published: January 2023

Bitácora pretende recuperar la ilustración local, por medio de una compilación de los que desarrollan esta actividad, imágenes creadas tanto por amateurs y profesionales. En esta edición encontraran trabajos con conceptos y técnicas muy diversas que les dejaran perplejos, asombrados, incómodos, felices, tristes. Este año se presentan 30 tripulantes para ser parte de Bitácora, esperamos con ansias que se enliste el próximo año y sea parte de este. 132 páginas ISBN: 978-9978-325-957 e-ISBN: 978-9978-325-66-7
Rayado (al)² book: Proceso creativo del diseñador
Authors:   Universidad del Azuay, Staël-apolo María Emilia , Tripaldi-Proaño Anna ,   Universidad del Azuay, Alvarracín-Espinoza Cristian ,   Universidad del Azuay, Landívar-Feicán Roberto ,   Universidad del Azuay
Published: January 2023

RAYADO AL CUADRADO BOOK es un libro que pone al alcance de todos los profesionales y estudiantes de diseño, un proceso creativo estándar para registrar actividades en cada etapa del proceso creativo; de esta manera, el usuario potencia cada vez más su trabajo productivo, garantiza la eficiencia y evita el frecuente desperdicio de tiempo, recursos y valor. 137 páginas ISBN: 978-9978-325-99-5 e-lSBN: 978-9942-778-02-4
Reflexiones sobre la evaluación académica
Authors:   Universidad del Azuay, Cobos-Cali Martha , Coronel-Coronel Iván ,   Universidad del Azuay, Veléz-Calvo Ximena ,   Universidad del Azuay, Burbano-Villavicencio Ana María ,   Universidad del Azuay, Ochoa-Arias María Elisa ,   Universidad del Azuay, Ochoa-Moreno Emilio ,   Universidad del Azuay
Published: January 2023

Lo que entendamos por calidad deseada debiera ser el mayor bien social y el más cuidado,por ser el más representativo del valor de lo que hacemos. Leemos que los bienes sociales solo existen mientras se los produce; eso ocurre con la calidad deseada: no nos llega desde afuera, no está en algo distinto de lo que hacemos, no es un atributo autónomo con existencia independiente, sino la expresión del valor de la construcción responsable,colectiva e inteligente de los cambios que alimentamos o no en el día a día.La Ley de Educación Superior del Ecuador se abre a este enfoque. La Ley define el principio de calidad como la búsqueda continua y auto-reflexiva del mejoramiento, aseguramiento y construcción colec tiva… de un balance entre docencia, investigación, vinculación y gestión, para el cumplimiento de los fines y propósitos de las instituciones de educación superior, búsqueda orientada por principios, a la cabeza de los cuales menciona el principio de pertinencia. CréditosRectorFrancisco Salgado ArteagaVicerrectora AcadémicaMartha Cobos Cali Vicerrector de InvestigacionesJacinto Guillén GarcíaDirectora de Comunicación yPublicacionesToa Tripaldi ProañoComisión de Evaluación Académica Martha Cobos, Iván Coronel, Ximena Vélez, Ana María Burbano, Elisa Alemán, Paúl Ochoa con la colaboración de Emi-lio Ochoa Moreno (Profesor honorario).Corrección de EstiloVerónica Neira RuizDiagr amación y Diseño de Portada Santiago Neira RuizDepartamento de Comunicación yPublicaciones 78 páginas ISBN:978-9942-822-51-2 e-ISBN:978-9942-822-52-9
Taller vertical4: Espacio y ciudad
Authors:   Universidad del Azuay, Espinoza Carlos , Flores-Murray Diana ,   Universidad del Azuay
Published: January 2023

En esta cuarta edición del Taller Vertical, nuestros invitados de Colombia y España, pudieron compartirnos sus perspectivas y experiencias sobre el tema del espacio público y, en conjunto con inivitados nacionales y locales, desarrollaron estas reflexiones en los diferentes talleres con estudiantes de todo el país. Los talleres se enfocaron en tres principales áreas de la ciudad, representativas de problamáticas actuales: el centro histórico, la ciudad consolidada y los barrios periféricos. 106 páginas ISBN: 978-9942-778-34-5 e-ISBN: 978-9942-778-35-2
Memorias del Congreso de Estudios de la Ciudad CIVITIC 2017: 02 Economía urbana y gobernanza
Authors:   Universidad del Azuay, Hermida-Palacios Carla
Published: January 2023

El volumen 2 recopila algunas ponencias de los ejes de economía urbana y gobernanza. El objetivo del Congreso dentro del eje de economía urbana era reflexionar sobre el funcionamiento y gestión de los diversos mercados del suelo urbano y vivienda y su incidencia directa sobre las finanzas públicas, así como conversar sobre las pusvalías diferenciales. Es decir, se buscaba reflexionar sobre las tendencias de crecimiento y segregación, la promoción inmobiliaria, los cambios en el acceso a la vivienda, entre otros. Por otro lado, el objetivo del eje de gobernanza era reflexionar sobre las transformaciones políticas y espaciales que experimentan las ciudades, así como las reformas orientadas a reducir la pobreza y las desigualdades urbanas; entendiendo a la gobernanza como un concepto que relaciona las diversas formas de organización y gestión cotidiana de una ciudad; y que tiene que ver con los satisfactores de necesidades básicas de la vida humana y el bienestar integral de la ciudadanía, así como los procesos de toma de decisiones. Así el volumen 2 de estas memorias se podrán leer ponencias sobre la plusvalia, los mercados de suelo, los grandes proyectos urbanos, y también sobre políticas de vivienda, de turismo, de transporte, y sobre planes de desarrollo y de ordenamiento territorial. Se abordarán casos ecuatorianos en Quito, Guayaquil, Cuenca y Loja pero también se revisarán temáticas internacionales latinoamericanas asentadas en el caso de Bogotá y de Santiago de Chile. 187 páginas ISBN: 978-9942-778-40-6 e-ISBN: 978-9942-778-41-3
Memorias del Congreso de Estudios de la Ciudad CIVITIC 2017: 03 Patrimonio
Authors:   Universidad del Azuay, Hermida-Palacios Carla
Published: January 2023

El volumen 3 recoge algunas de las personas presentadas dentro del eje de patrimonio. La convocatoria en este eje partió del hecho de que dentro de la cultura de la ciudad, la definición de patrimonio cultural material ha evolucionado más allá de los bienes históricos de la estructura urbana asociados solamente con los centros históricos y sus memorias. En la actualidad la configuración de la ciudad y la construcción de sus identidades demanda la visión más amplia de la valoración y la gestión del patrimonio cultural material. Es así que en el volumen 3 de estas memorias se podrá leer sobre arquitectura moderna, patrimonio inmaterial, política pública y también sobre patrimonio histórico. Se abordan los casos nacionales de Quito, Loja y Cuenca, y casos internacionales como Paypa y Bogotá. 167 páginas ISBN: 978-9942-778-42-0 e-ISBN: 978-9942-778-43-7
DO TOURISM GUIDANCE STUDENTS HAVE THE BRAND AWARENESS OF GÖBEKLİTEPE?
Authors: IŞIK Zennübe , TOKGÖZ Leyla , BAŞAR Fatma
Published: January 2023

When the destinations are evaluated within the scope of cultural tourism, the archaeological sites in the destinations have an important place for people curious about the past. Göbeklitepe, one of these archaeological sites, is located near Örencik village of Şanlıurfa Province. As a result of the archaeological excavations made in Göbeklitepe, whose history dates back to 10,000 BC, it has been determined that the archaeological site is the oldest place of worship and settlement in Anatolia so far. As a consequence of the excavations carried out in Göbeklitepe, symbolized by "T"-shaped stones, many more figures such as animal statues, jewelry and flint tools were unearthed. Göbeklitepe, the most exciting and intriguing archaeological discovery of recent times, is a unique sacred place of the Neolithic Period in terms of the location, dimensions, dating, and monumentality of architectural remains and sculptural pieces, and is the largest human-made cult center in the world to date. The purpose of the research carried out in this direction is to determine whether the students of the tourism guidance department have Göbeklitepe destination brand awareness. A questionnaire prepared for this purpose was applied to 383 graduate and undergraduate students of Tourism Guidance in Turkey. It was concluded that the brand awareness of Göbeklitepe differed according to the class level of the students, and the sources of learning about Göbeklitepe differed as their education levels differed. Within the scope of the study, suggestions were made to the instructors and students of the tourism guidance department.
Benefits and Limitations in Transoral Endoscopic Thyroidectomy
Authors: Hong Yong Tae
Published: January 2023

Transoral endoscopic thyroidectomy (TOET) is the recent remote access approach which leaves no cutaneous scar in the body. It has advantages in minimize the surgical dissection, could perform total thyroidectomy and central lymph node dissection easily under a good surgical view. TOET has gained popularity in both the East and Western countries since the first large series report by Dr. Anuwong in 2016. In this article we described and critically analyze the indications and contraindications, advantages and limitations, landmarks for recurrent laryngeal nerve and strategies for superior pole dissection in transoral thyroidectomy.
Awareness Analysis of the National Support Policy for Newborns and Infants With Hearing Loss Who Performed National Infant Health Checkup
Authors: Park Seok Hyun , Lee Jeongho , Cho Ky Young , Kim Hakyoung , Chang Jiwon , Choi Kyu Young , Park Su-Kyoung
Published: January 2023

Background and Objectives It is well recognized that early detection and intervention are most important for the prevention of neonatal hearing loss. The national support policy in Korea for newborn hearing screening has been changed since October 2018; however, parent awareness of the change still needs to be increased. This study investigated how well parents, who have underwent national infant checkups of their children, were aware of the Korean national policy for neonatal and infant hearing loss in parents.Subjects and Method A survey of neonatal hearing tests and national support policies conducted for 353 parents was analyzed. The survey included questions about parent awareness of the neonatal hearing screening test period, confirmatory test period, national support for these expenses, and hearing aid support. Also evaluated were the necessity of national guidance and management system for neonatal hearing.Results The test time of neonatal hearing screening was correctly recognized by 82.2% of the parents. The percentage increased after the national insurance coverage started in October 2018 in Korea, and the rate was higher for parents who visited an otolaryngology clinic rather than a pediatric clinic. The test time of the confirmatory test was correctly recognized only by 20.4%. National support policy for neonatal hearing screening tests, confirmatory hearing tests, and hearing aids were acknowledged by 50.7%, 43.1%, and 56.1% of the parents, respectively.Conclusion These results indicate the necessity of efforts to increase the awareness of neonatal hearing tests and relevant support policies in Korea to ultimately achieve early hearing detection and intervention of neonates and infants in Korea.
Kompensasi, Disiplin Kerja, dan Motivasi terhadap Kinerja Karyawan Bank Rakyat Indonesia Cabang Magetan
Authors: Haryanto Olyn Seftani , Farida F.Anif
Published: January 2023

Daya saing di sebuah perusahaan tidak luput dari kinerja karyawan termasuk dalam dunia perbankaan. Kinerja karyawan dapat diukur dari karyawan yang memiliki motivasi dan disiplin kerja yang optimal dan memiliki integritas tinggi pada lingkup perusahaan, karyawan atau biasa disebut sumber daya manusia adalah sebagai penggerak ekonomu dan juga merupakan penggerak utama dalam pencapaian tujuan suatu perusahaan. Penelitian ini memiliki tujuan untuk menguji pengaruh kompensasi, disiplin kerja dan motivasi terhadap kinerja karyawan pada Bank Rakyat Indonesia Cabang Magetan. penelitian ini dilakukan kepada 55 responden yaitu karyawan pada Bank Rakyat Indonesia Cabang Magetan dengan menggunkan metode probability sampling. Data penelitian diperoleh dengan membagikan kuisioner mengenai kompensasi, disiplin kerja, motivasi dan kinerja karyawan secara langsung kepada responden. Peneliti melakukan analisis data dengan menggunkaan software SPSS 24. Teknik analisis yang digunakan adalah regresi linier berganda. Hasil penelitian menunjukkan bahwa secara parsial kompensasi, disiplin kerja dan motivasi berpengaruh positif dan signifikan terhadap kinerja karyawan.
A standardised framework for the design and application of fine-scale acoustic tracking studies in aquatic environments
Authors: Orrell DL , Webber D , Hussey NE
Published: January 2023

Fine-scale tracking technology has advanced our understanding of aquatic animal behaviour by deriving near-continuous movements of animals ranging in size from small invertebrates to large predatory fish. Commercial fine-scale positioning systems, such as the VEMCO Positioning System, can pinpoint an animal’s location within metres of its true position. While methodological applications of commonly used presence-absence acoustic telemetry have identified factors that can limit array performance, the factors that influence position yield and accuracy and introduce error in fine-scale positioning systems have yet to be synthesised. Evidenced through a systematic review of the literature, we highlight key considerations and potential pitfalls faced when designing and conducting a fine-scale tracking study. Key factors impacting data acquisition are grouped under 4 key categories linked to the study system, species studied, and logistical and technological constraints. Thereafter, in line with these categories, we provide a framework that can be used prior to, during, and post-study to identify sources of error and data loss to optimize system design and acquired results. We provide details on user assessment tools that include a pre-study trial period using fixed tags to assess array geometry and data yield, an in situ checkpoint data download, and a post-study assessment of fixed transmitter performance. We highlight the utility of this framework and integrated assessment tools by presenting a real-world case study that ultimately was compromised. We anticipate that this framework can be used to standardize reporting of essential steps and checks that will generate comparable data for future synthesis, which will further advance fine-scale tracking approaches.
The Concept of Early Vascular Ageing – An Update in 2015
Authors: Nilsson Peter M.
Published: January 2023

Arterial ageing is a process that can be quantified, at least to some degree, by measurement of pulse wave velocity along the aorta, the largest elastic artery, as a marker of arterial stiffness. In recent years the new concept of early vascular ageing (EVA) has been developed by a group of mostly European researchers and some reviews have been published. Based on a lecture given at the European Association for the Study of Diabetes (EASD) Meeting in Vienna 2014, this review was written to describe recent developments in research dedicated to EVA and new emerging aspects found in studies of families at high cardiovascular (CV) risk. This brings new perspectives related to genetics, telomere biology, and the role of gut microbiota. Even if EVA has been described in general terms there is still no unifying definition available and no direct treatment, only recommendations for conventional CV risk factor control. However, a new intervention study (SPARTE) is ongoing in France with a randomised design to treat arterial stiffness in patients with hypertension versus conventional treatment strategies. Results are expected in a few years and will be of importance in defining the role of arterial stiffness, a core feature of EVA, as a target for treatment.
Transcatheter Aortic Valve Implantation: Review and Current State Of The Art
Authors: Collas Valérie , Philipsen Tine , Rodrigus Inez , Vrints Christiaan , Paelinck Bernard P. , Bosmans Johan
Published: January 2023

Since the introduction of transcatheter aortic valve implantation (TAVI) 12 years ago, the treatment options for severe, symptomatic aortic valve stenosis in high-risk patients have significantly increased. Because of the growing implementation of TAVI in clinical practice, knowledge of the outstanding clinical outcome of TAVI and TAVI-related limitations is expanding. In this review, potential complications, including stroke, vascular complications, paravalvular regurgitation, and conduction disturbances, are discussed. To reduce the incidence of these limitations, new valves are being designed and clinically evaluated. The ultimate goal is to reduce potential complications and expand the use of TAVI to lower-risk patient cohorts.
LITERATUR REVIEW : EFEKTIVITAS PIJAT AKUPRESUR TERHADAP KEJADIAN MUAL MUNTAH PADA IBU HAMIL TRIMESTER I
Authors: Risqiana Amanda , Wulandari Rr. Catur Leny , Jannah Muliatul
Published: January 2023

Introduction: Nausea and vomiting that occurs in pregnant women is a normal symptom and is often found in the first trimester of pregnancy. Nausea and vomiting in pregnancy are caused by changes in the endocrine system. The incidence of nausea and vomiting that occurs in Indonesia is much greater than the incidence in the world, namely 60-80% primigravida and 40-60% multigravida. How to cope with nausea and vomiting using non-pharmacological therapy, one of which is acupressure massage. Objective: To determine the effectiveness of acupressure massage on the incidence of nausea and vomiting in first trimester pregnant women. Methods: The method in writing this article is a review of the literature contained in the database of health journals, namely Google Scholar, pubmed, text books, profiles of the Ministry of Health, and the WHO website. The selected articles are based on free full text, open access, in English and Indonesian within the last 10 years. Results: The results of a literature study through databases in health journals found a total of 7 articles on pubmed, 7 articles on Google Scoolar. In the results of the study, there was a significant effectiveness of acupressure massage on the incidence of nausea and vomiting in pregnant women in the first trimester. Conclusion: Acupressure stimulates the regulatory system and activates endocrine and neurologic mechanisms, by stimulating the hypothalamus to secrete endorphins that provide a sense of relaxation. Keywords: Acupressure; Emesis gravidarum; First trimester pregnant women
KEPATUHAN TENAGA MEDIS DALAM MENGGUNAKAN APD DI BANGSAL COVID : STUDI KASUS DI RS X SEMARANG
Authors: Ambarita Ryna Mahdalena , Suryoputro Antono , Setyaningsih Yuliani
Published: January 2023

Covid-19 spreads massively and very fast in transmission. Health workers who work in hospitals were very vulnerable to being exposed to the Covid-19 virus. The used of personal protective equipment was very important for medical personnel serving patients in the Covid Ward to minimize the risk of transmission. The purpose of this study was to determine the factors associated with compliance with the use of personal protective equipment for health workers in the Covid Ward. This study was a quantitative study with the number of samples being the total population of Health workers on duty in the Covid Ward as many as 61 respondents. Statistical analysis was carried out using the Spearman Rho test. The results showed that there was no relationship between age (p = 0.406), education (p = 0.351), years of service (p = 0.216), knowledge (p = 0.344), attitudes (p = 0.434), availability (p = 0.328), and supervision (p=0.534) with the compliance of medical personnel in using personal protective equipment in the Covid Ward of RS X Semarang City. It was necessary to carry out sudden periodic inspections by the PPI team and the OHS team of RS X. And awards are given to health workers who comply with using personal protective equipment in addition to having imposed strict sanctions if health workers do not use personal protective equipment.
Analisis Tingkat Kepuasan Pengguna Aplikasi Dr. Oen SOBAtku Menggunakan Metode End User Computing Satisfaction (Eucs) Di Rumah Sakit Dr. Oen Solo Baru
Authors: Swastara Wihamara Elvando , Rimawati Eti , Faqih Haikal , Iqbal Muhammad
Published: January 2023

Aplikasi Dr.oen SOBAtku adalah salah satu fitur pelayanan pendaftaran poliklinik yang dapat dilakukan secara online bagi para pengguna melalui smartphone maupun komputer yang terhubung ke internet di Rumah Sakit Dr. Oen Solo Baru. Tujuan keseluruhan dari penelitian skripsi ini yaitu untuk menganalisis sejauh mana  tingkat kepuasan pengguna sistem aplikasi pada sistem pendaftaran online di Rumah Sakit Dr. Oen Solo Baru menggunakan metode End User Computing Satisfaction. Desain penelitian ini adalah bersifat kuantitatif dengan menggunakan metode pendekatan Cross Sectional. Penelitian ini menggunakan teknik pengambilan sampel yang dilakukan dengan non probability sampling menggunakan accidental sampling dengan jumlah sampel sebesar 100 pengguna aplikasi Dr. Oen SOBAtku . Pengumpulan data dalam penelitian ini diperoleh melalui data primer dengan kuosioner yang disebatkan kepada responden kemudian diolah menjadi data statistic.Hasil penelitian menunjukkan bahwa paling banyak responden berjenis kelamin perempuan sebesar 52 orang, 52 responden memiliki usia lebih dari 33 tahun, 40 responden memiliki tingkat pendidikan D3, 35 responden memilih pekerjaan lainnya, serta kelima variabel End User Computing Satisfaction memiliki hubungan yang signifian terhadap kepuasan pengguna (satisfaction) aplikasi Dr. Oen SOBAtku di Rumah Sakit Dr. Oen Solo Baru. Hasil kepuasan pengguna pada variabel EUCS menunjukkan hasil yang sangat puas dengan skala interpretasi 3,26-40.
Distribution of nutrients across the edible components of a modelled typical Australian lamb: a case study
Authors: Wingett Kate , Alders Robyn
Published: January 2023

Achieving sustainable development is one of the greatest challenges for humanity. This includes producing food in ways that enhance ecosystem, animal, and human health. There is a need for deeper understanding of nutrient distribution across the edible parts of animals, to better measure this enhancement. This study examined nutrient distribution across the carcase and co-products (edible offal and slaughter fat) derived from a typical Australian lamb, using modelling with secondary data. Due to insufficient data, some offal types were not included. Co-products accounted for 24% of total edible product by weight, 18% of protein and 37% of fat. The co-products contained 42% of iron content and the liver had more vitamin A, B12 and folate than all other products combined. This study highlighted the nutritional value of edible offal, especially liver, in the context of the whole animal and, the importance of including co-products in assessments of animal production systems.
A review of gender inequality and women’s empowerment in aquaculture using the reach-benefit-empower-transform framework approach: A case study of Nigeria
Authors: Adam Rahma , Njogu Lucy
Published: January 2023

Along the aquaculture value chain, what is the status of gender equality and women’s empowerment with a particular emphasis on aquaculture? What can be done to bring about gender equality and women’s empowerment in the aquaculture sector? This article explores these questions through a systematic review of the extant literature on gender and aquaculture using Nigeria as a case study. A total of 78 articles are analyzed based on the reach-benefit-empower-transform framework. The findings show that there is gender inequality within the aquaculture value chain. In most cases, women are mainly concentrated at the nodes of the value chain, which require fewer resources to operate; furthermore, in most cases, women earn less profits compared with their male counterparts. Women’s empowerment is still at the nascent stages, while gender related transformation has yet to take root. We recommend that pro-equality gender policies in aquaculture be created and implemented. This calls for the collection and use of sex-disaggregated data and for work at the grassroots level to ensure that the manner in which women, men, boys and girls are treated and allowed to live and function in the communities they reside engenders development, harmony, gender equality and prosperity. Finally, we recommend that the reach-benefit-empower-transform framework be expanded to facilitate the evaluation of program/project-based studies.
Peptide linker increased the stability of pneumococcal fusion protein vaccine candidate
Authors: Zane Luciano , Kraschowetz Stefanie , Trentini Monalisa Martins , Alves Vitor dos Santos , Araujo Sergio Carneiro , Goulart Cibelly , Leite Luciana Cezar de Cerqueira , Gonçalves Viviane Maimoni
Published: January 2023

Streptococcus pneumoniae is a bacterial pathogen exclusive to humans, responsible for respiratory and systemic diseases. Pneumococcal protein vaccines have been proposed as serotype-independent alternatives to currently used conjugated polysaccharide vaccines, which have presented limitations regarding their coverage. Previously in our group, pneumococcal surface protein A (PspA) and detoxified pneumolysin (PdT) were genetically fused and the hybrid protein protected mice against pneumococcal challenge, offered higher cross-protection against different strains and showed greater opsonophagocytosis rate than co-administered proteins. As juxtaposed fusion was unstable to upscale production of the protein, flexible (PspA-FL-PdT) and rigid (PspA-RL-PdT) molecular linkers were inserted between the antigens to increase stability. This work aimed to produce recombinant fusion proteins, evaluate their stability after linker insertion, both in silico and experimentally, and enable the production of two antigens in a single process. The two constructs with linkers were cloned into Escherichia coli and hybrid proteins were purified using chromatography; purity was evaluated by SDS-PAGE and stability by Western blot and high performance size exclusion chromatography. PspA-FL-PdT showed higher stability at −20°C and 4°C, without additional preservatives. In silico analyses also showed differences regarding stability of the fusion proteins, with molecule without linker presenting disallowed amino acid positions in Ramachandran plot and PspA-FL-PdT showing the best scores, in agreement with experimental results. Mice were immunized with three doses and different amounts of each protein. Both fusion proteins protected all groups of mice against intranasal lethal challenge. The results show the importance of hybrid protein structure on the stability of the products, which is essential for a successful bioprocess development.
Spectroscopic photoacoustic/ultrasound/optical-microscopic multimodal intrarectal endoscopy for detection of centimeter-scale deep lesions
Authors: Jiang Jinsheng , Yuan Chuqi , Zhang Jiaxi , Xie Zhuojun , Xiao Jiaying
Published: January 2023

The inadequacy of existing colorectal imaging tools has significantly obstructed the efficient detection of colorectal cancer. To address this issue, this work presents the cross-scale endoscopic imaging of rectal tumors with a combined photoacoustic/ultrasound tomography system and wide-field optical microscopy. This multimodal system combines the merits of centimeter-scale deep penetration, multi-spectral imaging, cross-scale imaging ability, low system cost, and 360° view in a single modality. Results indicated that the proposed system could reliably depict the location of the cancer invasion depth spectroscopically with indocyanine green The tumor angiogenesis can be well identified in the wide-field optical imaging mode, which helps to localize the tumors and guide the following photoacoustic/ultrasound scan. This work may facilitate the accurate characterization of colorectal cancer and promote the clinical translation of photoacoustic-based colorectal endoscopy.
Effect of void-carbon on blue-shifted luminescence in TADF molecules by theoretical simulations
Authors: Zhang Boyuan , Xu Haoyang , Xia Yumin , Wen Jin , Zhu Meifang
Published: January 2023

Thermally activated delayed fluorescence (TADF) molecules have a theoretical 100% photoluminescence quantum yield in comparison with traditional fluorescent materials, leading to broad application in organic light-emitting diode (OLED). However, the application of TADF molecules with conjugated donor-acceptor structures in blue OLED remains a challenge due to their generally narrow energy gap between frontier molecular orbitals. Recently, a strategy has been approved in the improvement of the performance in TADF, in which void-carbon atoms between donor and acceptor fragments (donor-void-acceptor (D-v-A)) could regulate blue light emission. In this study, we first select three reported isomers followed by two proposed D-v-A TADF isomers to verify the feasibility of the void-carbon strategy through evaluation of the electronic structures in the excited state and photophysical properties. We further proposed a series of TADF molecules by replacing different donor and acceptor fragments to assess the applicability of the void-carbon strategy from the aspect of simulations in electronic structures, different properties of donor and acceptor fragments, photophysical properties, and analysis in the molecular conjugation. The results indicate that void-carbon strategy has conditional feasibility and applicability. Donor-acceptor molecular properties could be tuned through void-carbon strategy on aromatic acceptor fragments during the selection of promising candidates of TADF molecules. However, the void-carbon strategy does not work for the molecules with antiaromatic acceptor fragments, where the steric hindrance of the molecules plays a dominant role. Our work provides insightful guidance for the design of the blue-emission TADF molecules.
Interaction of copper potential metallodrugs with TMPRSS2: A comparative study of docking tools and its implications on COVID-19
Authors: Vazquez-Rodriguez Sergio , Ramírez-Contreras Diego , Noriega Lisset , García-García Amalia , Sánchez-Gaytán Brenda L. , Melendez Francisco J. , Castro María Eugenia , de Azevedo Walter Filgueira , González-Vergara Enrique
Published: January 2023

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. For the virus to enter the host cell, its spike (S) protein binds to the ACE2 receptor, and the transmembrane protease serine 2 (TMPRSS2) cleaves the binding for the fusion. As part of the research on COVID-19 treatments, several Casiopeina-analogs presented here were looked at as TMPRSS2 inhibitors. Using the DFT and conceptual-DFT methods, it was found that the global reactivity indices of the optimized molecular structures of the inhibitors could be used to predict their pharmacological activity. In addition, molecular docking programs (AutoDock4, Molegro Virtual Docker, and GOLD) were used to find the best potential inhibitors by looking at how they interact with key amino acid residues (His296, Asp 345, and Ser441) in the catalytic triad. The results show that in many cases, at least one of the amino acids in the triad is involved in the interaction. In the best cases, Asp435 interacts with the terminal nitrogen atoms of the side chains in a similar way to inhibitors such as nafamostat, camostat, and gabexate. Since the copper compounds localize just above the catalytic triad, they could stop substrates from getting into it. The binding energies are in the range of other synthetic drugs already on the market. Because serine protease could be an excellent target to stop the virus from getting inside the cell, the analyzed complexes are an excellent place to start looking for new drugs to treat COVID-19.
Lingguizhugan decoction improves non-alcoholic steatohepatitis partially by modulating gut microbiota and correlated metabolites
Authors: Zhu Mingzhe , Wang Xue , Wang Kai , Zhao Zhiqiang , Dang Yanqi , Ji Guang , Li Fenghua , Zhou Wenjun
Published: January 2023

Background

Lingguizhugan decoction is a traditional Chinese medicine prescription that has been used to improve non-alcoholic fatty liver disease and its progressive form, non-alcoholic steatohepatitis (NASH). However, the anti-NASH effects and underlying mechanisms of Lingguizhugan decoction remain unclear.

Methods

Male Sprague-Dawley rats were fed a methionine- and choline-deficient (MCD) diet to induce NASH, and then given Lingguizhugan decoction orally for four weeks. NASH indexes were evaluated by histopathological analysis and biochemical parameters including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), liver triglycerides (TG), etc. Fecal samples of rats were subjected to profile the changes of gut microbiota and metabolites using 16S rRNA sequencing and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS). Bioinformatics was used to identify Lingguizhugan decoction reversed candidates, and Spearman’s correlation analysis was performed to uncover the relationship among gut microbiota, fecal metabolites, and NASH indexes.

Results

Four-week Lingguizhugan decoction treatment ameliorated MCD diet-induced NASH features, as evidenced by improved hepatic steatosis and inflammation, as well as decreased serum AST and ALT levels. Besides, Lingguizhugan decoction partially restored the changes in gut microbial community composition in NASH rats. Meanwhile, the relative abundance of 26 genera was significantly changed in NASH rats, and 11 genera (such as odoribacter, Ruminococcus_1, Ruminococcaceae_UCG-004, etc.) were identified as significantly reversed by Lingguizhugan decoction. Additionally, a total of 99 metabolites were significantly altered in NASH rats, and 57 metabolites (such as TDCA, Glutamic acid, Isocaproic acid, etc.) enriched in different pathways were reversed by Lingguizhugan decoction. Furthermore, Spearman’s correlation analyses revealed that most of the 57 metabolites were significantly correlated with 11 genera and NASH indexes.

Conclusion

Lingguizhugan decoction may exert protective effects on NASH partially by modulating gut microbiota and correlated metabolites.
A zone-of-inhibition assay to screen for humoral antimicrobial activity in mosquito hemolymph
Authors: Morejon Bianca , Michel Kristin
Published: January 2023

In insects, antibacterial immunity largely depends on the activation of downstream signaling and effector responses, leading to the synthesis and secretion of soluble effector molecules, such as antimicrobial peptides (AMPs). AMPs are acute infection response peptides secreted into the hemolymph upon bacterial stimulation. The transcription of innate immunity genes encoding for AMPs is highly dependent on several signaling cascade pathways, such as the Toll pathway. In the African malaria mosquito,Anopheles gambiae, AMPs hold a special interest as their upregulation have been shown to limit the growth of malaria parasites, bacteria, and fungi. Most of the current knowledge on the regulation of insect AMPs in microbial infection have been obtained fromDrosophila. However, largely due to the lack of convenient assays, the regulation of antimicrobial activity in mosquito hemolymph is still not completely understood. In this study, we report a zone of inhibition assay to identify the contribution of AMPs and components of the Toll pathway to the antimicrobial activity ofA. gambiaehemolymph. As a proof of principle, we demonstrate thatMicrococcus luteuschallenge induces antimicrobial activity in the adult female mosquito hemolymph, which is largely dependent on defensin 1. Moreover, by using RNAi to silenceCactus,REL1, andMyD88, we showed thatCactuskd induces antimicrobial activity in the mosquito hemolymph, whereas the antimicrobial activity inREL1kd andMyD88kd is reduced after challenge. Finally, while injection itself is not sufficient to induce antimicrobial activity, our results show that it primes the response to bacterial challenge. Our study provides information that increases our knowledge of the regulation of antimicrobial activity in response to microbial infections in mosquitoes. Furthermore, this assay represents anex vivomedium throughput assay that can be used to determine the upstream regulatory elements of antimicrobial activity inA. gambiaehemolymph.
Case report: Metastatic myxoid liposarcoma arising from the right atrium extends as cardiac tamponade—A rare case of atrial oncology
Authors: Thoddi Ramamurthy Muralidharan , Kumar Balakrishnan Vinod , Sunny Sini , Rajkumar Abinayaa , Sundaram Sandhya , Krishnamurthy Preetam , Boopathy Senguttuvan Nagendra , Murali Arunan , Santhosham J. D. Roy , Periandavan Kalaiselvi , Rajasekaran Namakkal S.
Published: January 2023

The reported incidence of liposarcomas in ~2,000 cases annually results in about 30% of myxoid liposarcomas. Cardiac myoxid liposarcomas are very rare; their presentation could be cardiac tamponade, due to direct compression of the tumor and/or pericardial effusion. In this report, we describe a patient who presented with pericardial effusion secondary to myoxid liposarcomas from the right atrium, an extremely rare presentation of liposarcomas in the heart. We also present non-invasive imaging through echocardiography, CECT thorax and FDG PET scans, followed by a CT-guided mass biopsy. Histopathology of the right atrial mass demonstrated myxoid liposarcoma positive for the S100 tumor marker.