bluuebunny/crossref_metadata_2025 huggingface dataset:
Atezolizumab (Tecentriq) as first-line therapy in patients with metastatic urothelial carcinoma
Authors: Gritskevich A. A. , Baitman T. P. , Mishugin S. V. , Popov A. Yu. , Oganyan V. A. , Rusakov I. G. , Kostin A. A.
Published: December 2022

Introduction. Nowadays the standard of care for locally advanced and metastatic urothelial carcinoma (UC) is a combination of platinum-based drugs. However, such a therapy is characterized with high toxicity and selective efficacy. So, the question of the optimal alternative to the first line of therapy and the choice of drugs for the second line of therapy is currently relevant.

Immune checkpoint inhibitors have revolutionized the treatment of UC. Nevertheless, despite the fact that initially the drugs of this series showed a fairly high efficacy as a second-line therapy for metastatic UC, at present there is no unambiguous opinion about the correct tactics of their use. There is also no consensus on the predictive value of PD-L1 biomarkers and their significance in determining treatment tactics.

Aim. To evaluate the efficacy and tolerability of first-line atezolizumab therapy in 22 patients with unresectable forms of UC.

Materials and methods. The experience of the State Clinical Hospital named after D.D. Pletnev on the example of 22 patients with advanced UC who received first-line therapy with atezolizumab 1200 mg intravenously once every 21 days until progression or intolerable toxicity. Efficacy was assessed according to RECIST 1.1 criteria.

Results and discussion. Median follow-up 16.3 months. The objective response rate (ORR) is estimated at 72.7%, 95% CI. A complete response according to RECIST 1.1 criteria was observed in 5 patients (22.7%). Median time to first response was 2.2 months (range 1.5-5.7), late responses (at 5 and 5.7 months) required space in 2 patients. Median progression-free survival was 5.2 months (95% CI) in all patients. Median overall survival (OS) 18.5 months (95% CI). Specific application-related events were required in 10 (45.4%) cases. All the side effects were managed by standard symptomatic therapy. The dosage of atezoli-zumab was reduced in 7 (32%) cases. Immune-mediated adverse events were reported in 5 (23%) patients. No patient received systemic non-corticosteroid immunomodulatory agents for immune-mediated events. 2 (9%) patients received corticosteroids.

Conclusions. Atezolizumab has shown high efficacy in the first line of treatment for advanced UC.
Experience of using acalabrutinib therapy in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Piskunova I. S. , Moiseeva T. N. , Al-Radi L. S. , Plastinina L. V.
Published: December 2022

Introduction. Thanks to scientific advances and discoveries in the study of tumor cell biology, new effective drugs for the treatment of chronic lymphocytic leukemia/ small lymphocytic lymphoma have emerged. Currently, there are drugs with different application points at the molecular level. One such drug is acalabrutinib, which is a selective second-generation inhibitors of Bruton tyrosine kinase and has a more favorable toxicity profile.

Objective. To evaluate the efficacy of acalabrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.

Materials and methods. Since February 2020 acalabrutinib (100 mg 2 p/day orally) has been administered to 7 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (mean age 64 years) at the Hematology Research Center. Six patients received acalabrutinib in 1st-line therapy and one patient received acalabrutinib in 2nd-line therapy. The mean comorbidity index (CIRS) of the patients was 10 points (range, 8 to 14). Most patients had at least one of the adverse prognostic factors - IGHV nonmutated gene status, TP53 gene aberration (del17p13 and/or TP53 gene mutation), complex karyotype disorders.

Results. All patients achieved partial remission of the disease (overall response 100% in the form of regression of B-symptoms, lymphocytic leukocytosis, splenomegaly) at the control period of treatment with acalabrutinib +12 months. The most frequent adverse events when taking acalabrutinib were the occurrence of headache in the first month of taking the drug, spontaneous subcutaneous hematomas. No hematologic toxicity, infectious complications, or cardiac complications were noted. At a median follow-up of 34 months, no patient showed disease progression.

Conclusions. The selective Bruton tyrosine kinase inhibitor acalabrutinib has demonstrated high efficacy in patients with adverse risk factors, good tolerability and minimal toxicity, including in comorbid patients.
Oral combination of netupitant and palonosetron for the of nausea and vomiting induced by chemotherapy
Authors: Koroleva I. A. , Kopp M. V.
Published: December 2022

Nausea and vomiting are the most frequent and painful adverse event of chemotherapy. Uncontrolled nausea and vomiting lead to a significant decrease in the quality of life of patients, nutritional insufficiency, breaking of the chemotherapy therapy regimen. Nausea and vomiting worsen the result of chemotherapy and the prognosis of the disease. In clinical studies of antiemetic drugs the “complete response” is used as the primary endpoint. The complete redponse is the absence of nausea and vomiting and the need for additional antiemetic drugs. The oral combination of netupitant and palonosetron is a modern drug for the prevention of nausea and vomiting induced by chemotherapy. This combination includes a highly selective anatagonist of NK1-receptors netupitant at a dose of 300 mg and an antagonist of 5-HT3 receptors palonosetron at a dose of 0.5 mg. The combination of net-upitant and palonosetron has high compliance, it is prescribed once before chemotherapy. The combination of netupitant and palonosetron makes it possible to achieve complete control of acute (0-24 hours) and delayed (24-120 hours) nausea and vomiting with highly emetogenic chemotherapy. In a randomized trial (n = 1455) with AC chemotherapy (doxorubicin + cyclophosphamide), the combination of netupitant and palonosetron resulted in a complete response during the general phase (0-120 hours) in 73.3% of patients. 78.4% of patients with the combination of netupitant and palonosteron experienced “no effect on daily life” due to nausea and vomiting. In an observational study of real clinical practice (n = 1197), the combination of netupitant and palonosetron in the AC chemotherapy regimen (doxorubicin + cyclophosphamide) had a complete response during the general phase (0-120 hours) in 81% of patients. Adverse events when using the combination of netupitant and palonosetron are minimal, constipation was noted in 1-8% of cases, headache in 1.4-3.6% of cases.
Arianism and Pelagianism: Two Great Heresies of the Fourth and Fifth Centuries
Authors: BERGERON Sylvain
Published: December 2022

At a time in Western civilization when differing religious theologies were at odds with each another, opposing schools of thought attempted to reformulate and rationalize some of the most fundamental teachings at the heart of early Christianity. As the founders of these schools were branded as radicals and heretics for defying the orthodoxy and authority of the Roman Empire and at the same time, of the Roman Catholic Church, these teachers were soon ostracized and harshly punished for their flawed and erroneous beliefs. Focusing on the fourth and fifth centuries of the Common Era specifically, this paper will introduce two great heresies that belonged to those historical periods namely, Arianism and Pelagianism, and the highly influential, yet controversial thinkers behind them. Formulated by the Cyrenaic (modern-day Libya) presbyter, Arius (256-336 CE) and the British monk and theologian, Pelagius (390-418 CE), these two religious figures whose nonconformist theological positions are still being debated today, dared in their own defiant ways to challenge the firmly established rules and doctrines of Crown and Church.
Activities of Hemavend Tribe in Eyalet of the Archipelago (Eyālet-i Cezāyir-i Baḥr-i Sefīd in Ottoman Turkish) (1889 -1905)
Authors: BAYKARA TAŞKAYA Arzu
Published: December 2022

The Hemavend, a Kurdish tribe, were exiled from their original settlements of Kirkuk, Aleppo and Mosul to the Eyalet of the Archipelago, especially Chios, Kos and Rhodes Island. This Kurdish population, whose total number was close to 200, did not see this province, which was a place of exile, as a place to stay due to insecurity and disorder, especially the weather. The people of Hemavend, who made their situation worse by escaping from this province, lived separately from their families, which made their lives worse. The financial burden given to the state by these people, who stayed in various parts of the province's sanjaks such as Rhodes, Lemnos, Chios, was tried to be met from various sources of the province. The main demands of the tribe from the state were to allow them to go to provinces such as Mosul, Damascus, Aleppo, Adana, which they see more suitable for their living conditions. There are a lot of documents in the archive that the households in the tribe demanded to come together because they were broken up in this way. The state preferred to increase their daily wages rather than sending these households to other provinces. In order for these people to make a living, the state paid a certain number of daily wages, and the members of the tribe, who stated that they could not get along, constantly demanded an increase in their daily wages. The places where the tribal members stayed were generally the households that were crowded and far from sanitary conditions. Unfortunately, although it was accepted that the state expelled the Hemavend tribes from their homeland for just cause, these people could not escape from falling into a miserable situation. The forgiveness of some of the exiles was a good example of the state's conscientiousness. Our article, which benefited from the Prime Ministry Ottoman Archive documents, aims to illuminate the conditions and numbers of the Hemavend tribe in the Eyalet of the Archipelago with the documents reflected in the archive; it is tried to give a cross-section of the social and economic history of the Ottoman Empire. In the article, the economic distress and security problems that occurred with the settlement of the Hemavend Tribe in the Eyalet of the Archipelago from the end of the 19th century were also determined.
İngiliz Siyasi Subay H.C. Luke’un Güney Kafkasya Raporu (4 Kasım 1919)
Authors: TURAN Orhan
Published: December 2022

Bolşevik İhtilâli, Çarlık Rusyası egemenliğindeki uluslar için yeni bir dönemin habercisi oldu. Rus İmparatorluğu’nun sürüklendiği iç savaş atmosferi bağımsızlık hareketleri için elverişli bir ortam sağladı. Kısa süre içerisinde Güney Kafkasya’da Azerbaycan, Ermenistan ve Gürcistan’ın oluşturduğu federatif bir yapı ortaya çıktı. Daha açık bir ifadeyle 1918 Nisan’ında Transkafkasya Bağımsız Demokratik Federatif Cumhuriyeti kuruldu. Ardından üç devlette bağımsızlıklarını ilan etti. I. Dünya Savaşı’nın sona ermesiyle birlikte Kafkasya’nın da kaderi değişmeye başladı.

İngiltere, Osmanlı Devleti’nin mütareke isteyerek savaştan çekilmesiyle Güney Kafkasya’ya odaklandı. Zira Kafkaslar stratejik ve ekonomik açıdan İngiltere için büyük önem arz etmekteydi. Buradaki yeraltı enerji kaynakları ile Batum, Tiflis ve Bakü güzergâhı imparatorluğun himayesi altında olmalı idi. Bu bağlamda İngiltere mütareke koşullarını kendi çıkarları doğrultusunda olabildiğince zorladı. Öyle ki bölgenin önemli şehir merkezlerinde askeri üsler bile inşa etti.

Çalışmada 4 Kasım 1919 tarihli İstanbul’daki Yüksek Komiser Amiral J. de Robeck’in görevlendirdiği Siyasi Subay H. C. Luke’un hazırladığı Londra’da İngiliz Milli Arşivinden temin edilen “Report on the Situation in Transcaucasia” başlıklı rapor değerlendirilecektir. Mevcut rapor Bolşevik İhtilâli’nden sonra Güney Kafkasya’daki siyasi ve askeri gelişmeleri ortaya koymaktadır. Rapor özellikle Gürcistan, Azerbaycan ve Ermenistan özelinde yaşanan olayları İngiliz bakış açısından ele almaktadır. Yine Türk, Alman, Rus başta olmak üzere diğer ulusların bölgeye olan etkisi de burada dile getirilmiştir.

Çalışma, Mondros Mütarekesi sonrası dönemde Güney Kafkasya’da ortaya çıkan siyasi ve askeri gelişmeler ışığında büyük ve yerel güçler arasında yaşanan rekabeti rapor doğrultusunda ele almaya gayret edecektir. Konunun ana malzemesini, İngiliz Milli Arşivi’nden elde edilen Report on the Situation in Transcaucasia başlıklı rapor temel oluşturacaktır.
Bellek, Tarih ve Siyaset: Walter Benjamin’in Tarih Metodolojisi
Authors: AKKANAT Salih
Published: December 2022

Benjamin’in tarih felsefesi şimdiki zaman, tarih, bellek ve siyaset kavramları arasında kendine özgü bağlantılar kuran eleştirel bir çabadır. Benjamin, tarihsicilik (historicism) olarak adlandırılabilecek geleneksel tarih görüşünü, tarihsel bilginin hakikatine ilişkin benimsediği yöntem bakımından eleştirmektedir. Kavram eksenli bir tarih görüşü yerine deneyimi temel alan bir yöntemle tarih düşüncesinde yeni bir perspektif değişimini savunan Benjamin, modern tarih yazımını monad, diyalektik imge, takımyıldızı gibi estetik kategoriler ile tanıştırır. Benjamin, tarihi deneyimden hareketle düşünmeye çalışır. Deneyim bilgisine soyutlama ve genelleştirme yoluyla ulaşmak ya da deneyimin kavrama tabi kılınması; deneyimin üretildiği bağlamın gözden kaybolması anlamına gelmektedir. Nitekim felsefe tarihinde maddi yaşam ve zihinsel yaşam arasında bir ayrım yapılırken; maddi, somut, pratik deyim alanı, düşünce evreni karşısında değersizleştirilmiştir. Benjamin, Dilthey’den itibaren yaşam filozoflarının da şiire, saflıkla özdeşleştirilen doğaya ve mitoslara göndermede bulunarak, hakiki deneyime ulaşmaya çalıştıklarını söyler. Bu makale, Benjamin’in zamansallık ve tarihyazımı düşüncesi bağlamında deneyime dayanan bir tarihsellik fikrine nasıl ulaşılabileceğini göstermeyi amaçlıyor. Tarihi, deneyim kavramının ışığında düşünmek; güç ve iktidar ilişkilerini vurgulayan, maddi ve somut çıkarların bilgisi üzerinde yapılanmış, tarihte ve bugün egemen kamusallık biçimiyle ilişkisinde, farklı nedenlerle damgalanarak tarihsel gerçeklikten dışlanmış olanların katılımına açık bir tarih anlatısı geliştirmeyi mümkün kılabilir. Bu açıdan makale, tarihsici tarih düşüncesine karşı Benjamin’in geliştirdiği eleştirel tarih görüşünün temel parametrelerini belirlemeyi ve bunları etik ve politik sonuçları itibariyle tartışmayı amaçlıyor. Tarih felsefesine ve özellikle tarih yazımına verdiği önem, bir amaç olarak kendini geleceğe yönlendiren bir eylem kavramından ziyade, mevcut tahakküm sistemlerine ve onların kendi hegemonik tarih görüşlerini dayatmalarına karşı çıkan bir siyasal eylem teorisi geliştirmek istemesinden kaynaklanmaktadır. Bu tarz bir siyaset anlayışı, hâkim olanın her zaferini yeni baştan sorgulayarak, aslında tüm siyasal sistemlerin temel tarihselliğini, değiştirilebilirliğini ve sonluluğunu açığa çıkarmaya yönelir. Böylece, geçmişin farklı ve her zaman benzersiz başlangıçların kaynağı olarak görülebileceğini göstermeyi amaçlar. Bu nedenle bellek ve tarih, hatırlama ve müdahale ayrılmaz bir bütünlük oluşturur.
Osmanlı Devleti’nin Avrupa Diplomasisinde Posta Sorunu Üzerine Bazı Değerlendirmeler
Authors: ASLAN Taner
Published: December 2022

Osmanlı Devleti’nin 19. Yüzyılda karşılaştığı sorunlar arasında yabancı posta sorunu önemli bir yer teşkil etmiştir. Bu postalar Avrupalı devletler ile Osmanlı Devleti arasında yapılan muhtelif antlaşmaların bir neticesi olarak ortaya çıkmış, birçok yerde yabancı posta acentelikleri büro açmışlardır. Başlangıçta sadece sefaret postalarını taşımak üzerine kurulan yabancı postalar, ticaretin, haberleşmenin gelişmeye başladığı üretim ve dağıtım ağına duyulan gereksinimin giderek önemli olduğu 19. Yüzyılda posta hizmetleri halkın ve tüccarların haberleşmesin de de kullanılmıştır. Zamanla kurumsal bir yapı haline gelen bu postaların yasak yayın, kaçak silah, insan kaçakçılığı vb. zararlı ve hukuka aykırı maddelerin naklinde araçsallaştırılması, Osmanlı Devleti açısından önemli bir güvenlik sorunu meydana getirmiştir. Devlet bu sorunu ortadan kaldırmak için öncelikli olarak Osmanlı postalarının modernizasyonunu sağlamaya çalışmıştır. Bir devlet meselesi olarak görülen yabancı postaların kaldırılması devletin öncelikli gündem maddeleri arasında yer almıştır. Bunu diplomatik kanallar vasıtasıyla ortadan kaldırmayı denemiş, ancak yabancı devletlerin olumsuz yaklaşımları nedeniyle bir sonuç alınamamıştır. Çalışmada Osmanlı Devleti’nin yabancı postalar sorununu çözmek için yaptığı diplomatik faaliyetler ele alınmıştır.
Saltanatın Kaldırılması Sürecinde Refet Paşa’nın Siyasal Söylemlerinin İç ve Dış Basında Yansımaları
Authors: AKÇA Seher
Published: December 2022

Milli Mücadelenin cephelerde yürütülen askeri safhası, 1922 yılında zaferle sonuçlandırılmıştır. Batı Cephesinde Sakarya Savaşı’yla ileri harekâta geçen Türk Ordusu, Ağustos 1922’de Büyük Taarruz ve Başkomutan Meydan Muharebesi ile kesin zafere ulaşmıştır. Bundan sonraki süreç, askeri zaferin diplomasi zaferiyle taçlandırılması olacak; bu zafer de, Mudanya Mütarekesi ve Lozan Barış Anlaşması ile kazanılacaktır.

Mudanya Mütarekesi, Türk-Yunan kuvvetleri arasındaki filli savaş durumuna son vermiş ve ileride yapılacak barış anlaşmasına zemin hazırlamıştır. Mütareke hükümleri gereğince en önemli husus ise, Edirne dâhil olmak üzere Doğu Trakya’nın kademeli olarak Yunan kuvvetleri ve müttefikler tarafından boşaltılması, Ankara Hükümetine teslim edilmesi olmuştur. Ankara Hükümeti Refet Paşayı Trakya’yı teslim almakla görevlendirmiş; kendisine, Ankara Hükümetini İstanbul’da temsil etme yetkisini de vermiştir.

Bu çalışmada TBMM tarafından resmi olarak görevlendirilen Refet Paşa’nın İstanbul’da saltanat idaresine yönelik nutukları ve saltanat-hilafet makamları nezdinde takındığı tutum ve davranışları, saltanatın kaldırılma sürecindeki yeri ve bu sürecin iç ve dış basında yansımaları itibariyle değerlendirilecektir.
Cultural Heritage as a Factor of Cooperation between Countries of the Balkan Region
Authors: HAJZERİ Pajazit
Published: December 2022

Cultural heritage as factors of cooperation and interaction is one of the challenges facing Southeast Europe, more specifically the Western Balkans.

The historical past and cultural diversity of each country in this region is closely related to its past, with monuments of construction heritage, movable, immovable, sacred and secular monuments, of different faiths, with social, religious character etc.

Cultural diversity in heritage is the most complex and challenging area in terms of our past as a region, so regional cooperation is more than necessary to channel the facts and equate historical evidence to mitigate the irritations and territorial claims of neighbors to the detriment. of others.

Kosovo in particular has a number of problems related to the historical past closely linked to cultural heritage as a result of non-recognition by UNESCO leaving room for others to make claims.

Special areas protected by the Ahtisaari Package were erected around some Orthodox cult monuments to usurp the surrounding properties under the pretext of security, while the properties were private (the case is with the Boletin church in Mitrovica district which usurped the lands of Isa's family Bulletin).

All this situation would have ended if UNESCO had recognized the cultural heritage of Kosovo as the heritage of Kosovo regardless of which ethnicity or cult it belongs to, aiming at regional cooperation in the cultural diversity that surrounds us.
Osmanlı Modernleşme Döneminde Sason’da Eğitim
Authors: YILDIZ Hatip
Published: December 2022

Güneydoğu Anadolu Bölgesinin Yavuz Selim Dönemi’nde Osmanlı hâkimiyetine girmesiyle, Batman ilinin bugünkü sınırları içinde yer alan Sason kazası ile bağlı nahiye ve köylerin tamamı uzun yıllar Diyarbekir Vilayetinin idari yapısı içerisinde yer almıştır. Fakat 1879 yılında Bitlis Vilayetinin teşekkülüyle Sason kazası Diyarbekir Vilayetinden ayrılarak buraya bağlanmıştır. Bu durum, tespit edilebildiği kadarıyla Osmanlı Devleti’nin sonuna kadar aynı şekilde devam etmiştir.

Osmanlı Devleti’nde Tanzimat Fermanı’nın ilanından sonra daha planlı bir şekilde yürütülen modernleşme çalışmaları, İstanbul’un dışında yani vilayetlerde de peyderpey hayata geçirilmiştir. Bu dönemde merkezde olduğu gibi taşrada da yenilik yapılan alanlardan biri de eğitimdir. Bilhassa 19. yüzyılın ikinci yarısından itibaren vilayetlerde farklı düzeylerde pek çok modern eğitim kurumu açılmaya başlanmıştır. Bu doğrultuda Sason kazasında da Maarif Nezaretine bağlı olarak çok sayıda yeni okul açılmış olup başlıcaları Sason (Hazzo), Bozikan, Kabılcevz, Tızi, Reşnik, Cemalan, Hatni, Asi ve Koskit ibtidaileri ile Hazzo Hamidiye İbtidaisi ve Hazzo Rüşdiyesidir. Bu Müslüman okullarının yanı sıra Hazzo (Kozluk)’da bir Ermeni mektebi de açılmıştır.

Bu çalışmada, söz konusu ibtidai ve rüşdiye mekteplerinin açılışları ile öğretmen, öğrenci, ders, eğitim ve mali durumları ayrıntılı olarak incelenmiştir. Böylece sosyokültürel yapısından dolayı bilhassa Sultan II. Abdülhamid Dönemi’nde eğitim düzeyinin yükseltilmesine oldukça önem verilen Sason kazasının modern eğitim yapısı ve bölgede izlenen eğitim politikaları ana hatlarıyla ortaya konulmuştur.

Çalışmanın hazırlanmasında Maarif Salnameleri, Maarif İstatistikleri, Bitlis Vilayet Salnameleri, Osmanlı Arşivi Maarif Nezareti belgeleri ve konuyla ilgili araştırma eserlerden faydalanılmıştır.
Feasibility and Effectiveness Assessment of Strategies and National Projects in the Context of Global Transformations
Authors: Kochemasova Ekaterina , Kochemasov Yury
Published: December 2022

Problems, threats, and risks are often considered selectively in national strategies and projects. As a result, new factors appear during their implementation: they limit the solution of strategic tasks, cause crisis phenomena, and recurrent gaps in the socio-economic development. The authors developed a procedure of causal analysis. It focuses on entire path of problem development, from the establishment of its root and indirect causes to the determination of direct and visible changes in the human living environment. The analysis features the completeness of factor accounting in problems, threats, and risks. It also covers strategic objectives and targets to assess the feasibility of strategic priorities and the effectiveness of project activities. The article also introduces some methodological tools of the causal analysis. They can be applied to factors that affect strategic planning and can be used to assess national projects, i.e., their feasibility of strategic objectives and effectiveness.
Strategizing the Digital Transformation of Higher Education
Authors: Shatskaya Irina
Published: December 2022

Nowadays, digitalization is affecting all sectors of global economy, including higher education. This process should be conscious and well-structured. This study featured the digitalization phenomenon in higher education, namely its impact on human resources and the strategizing of digital transformation.The author used the theory of strategy and strategizing methodology developed by Professor V.L. Kvint to design the strategy of the digital transformation in the sphere of higher education in Russia. Other methods and approaches included analysis, synthesis, comparison, generalization, and scientific abstraction. The study resulted in a conceptual framework for strategizing the digital transformation of higher education in Russia. The OTSW analysis proved that the digital transformation of higher education is currently experiencing various difficulties. Most of them are associated with the penetration of digital technologies into academic environment, the socio-psychological risks, and the personality digitalization. The Russian system of higher education needs effective digital strategizing and a clear methodology to overcome all these difficulties.
Factores asociados a la sobredosis no fatal en personas que se inyectan drogas en Colombia
Authors: Valencia-Ortiz Nelcy Lorena , Berbesi-Fernandez Dedsy Yajaira
Published: December 2022

Objetivo: analizar los factores sociodemográficos, conductas de inyección y comportamientos asociados a la sobredosis no fatal en personas que se inyectan drogas en Colombia. Métodos: estudio analítico transversal en 1123 personas que se inyectan drogas en cinco ciudades de Colombia. Las personas se encontraban entre los 18 y 59 años de edad. Como variable dependiente se consideró el presentar o no sobredosis. Se indagaron por variables demográficas y comportamientos de riesgo asociados a la sobredosis. Resultados: de las personas que presentaron sobredosis, el 85,8% eran hombres. El 62,3% alcanzaron estudios de secundaria. 61,7% eran de estrato socioeconómico bajo. Factores como vender drogas, dividir la mezcla, y estar presente cuando alguien tuvo sobredosis, fueron características que estuvieron asociadas al haber tenido sobredosis. Conclusiones: las prácticas de inyección y los comportamientos están asociadas al haber tenido sobredosis. Las acciones de salud pública encaminadas a la modificación de algunas prácticas de inyección pueden contribuir a la disminución de sobredosis y las secuencias que esta genera.
Quantifying the impact of climate change and human activities on the eco-hydrological regimes of the Weihe River Basin, Northwest China
Authors: Jiang Shanhu , Liu Yating , Wang Menghao , Zhu Yongwei , Cui Hao , Du Shuping , Xu Chong-Yu
Published: December 2022

Climate change and anthropogenic interventions have obviously altered the eco-hydrological regimes. A quantitative evaluation and attribution of the eco-hydrological alterations are urgently required. In this study, we evaluated the various attributions of eco-hydrological regimes in the Weihe River Basin (WRB). Firstly, the trends and change-point analysis of hydrological elements were examined, and the natural streamflow was reproduced based on the variable infiltration capacity model. Then, the most ecologically relevant hydrological indicators (ERHIs) were selected and combined with the eco-deficit and eco-surplus indicators to assess the degree of eco-hydrological regime alterations. Finally, the relative contributions to eco-hydrological alterations were quantified using the ‘simulated–observed comparison’ method. The results showed that (1) the streamflow of the WRB exhibited significant decreasing trends (p < 0.01), and a significant change point (p < 0.01) of the streamflow series was identified in 1990. (2) Seven representative indicators of hydrological alteration were selected as ERHIs. (3) During the human-induced period (1991–2017), human activities were the dominant factors in the eco-hydrological alterations as well as the variations of the ERHI indexes and the eco-deficit and eco-surplus metrics. Overall, the proposed framework may improve the understanding of the driving forces of eco-hydrological regime alterations under a changing environment.
Diffusion of point source pollution at the cross joint
Authors: Sun Bin , Peng Qingfeng , Ma Wenjun , Li Zhiwei , Song Zhanqi , Tong An
Published: December 2022

The cross joint is one of the standard connection types for urban water supply pipelines. A pipeline containing cross joints was taken as the research object using NaCl as the tracer. The turbulent mixing characteristics of water and pollutants at the cross joints and pollutant migration and diffusion were studied and analysed by numerical analysis and experimental measurement. The primary purpose is to check the comprehensive influence of the six factors of pipe diameter, inlet flow ratio, outlet flow ratio, location of damage point, flow of brine, and density of brine on the turbulent mixing of water and brine in the pipeline. The coefficient of variation is used as an evaluation index to evaluate the mixing in the pipeline, and the effective mixing length LEML is used to quantify the uniform mixing position of brine in the pipeline. The results show that the inlet flow ratio, outlet flow ratio, and pipe diameter significantly affect LEML in the east outlet of the cross joint. Outlet flow ratio and pipe diameter significantly affect LEML in the cross joint's south outlet direction. In addition, the dimensionless relationship equation representing LEML is fitted through dimensional analysis.
Ayurveda foundation of pharmaceutical medicine
Authors: Suryani Ni Gusti Ayu Putu
Published: December 2022

The Ayurveda is a part of the Smrti Veda in Hinduism, which contains a lot of traditional knowledge that has been very useful for human life throughout the ages. Because it is so very complex in terms of treatment, the Ayurveda is also used as a basic foundation in medical treatment. The science that manages medical drugs is called pharmacy. In pharmaceutical development, from finding medicinal ingredients to the stage of making drugs so as to produce drugs and distribute drugs according to the rules set by the Health Service. So that once the medicines reach the patient there are no problems, the patient becomes completely healthy as expected. Pharmacists in today's Ayurveda era are still used as a basis for making medicines.
EFFICIENT AND SUSTAINABLE ENERGY MANAGEMENT FOR HOSPITAL BUILDING
Authors:   Postgraduate Program in Hospital Management Faculty of Medicine Universitas Brawijaya Malang Indonesia, Annura Sakinah , Arabikum Jihan , Aminingrum Rahmawati , Ulu Zainal ,   ostgraduate Program in Hospital Management Faculty of Medicine Universitas Brawijaya Malang Indonesia, Wahyudi Dwi ,   ostgraduate Program in Hospital Management Faculty of Medicine Universitas Brawijaya Malang Indonesia, Zuhriyah Lilik ,   Department of Public Health Faculty of Medicine Universitas Brawijaya Malang Indonesia
Published: December 2022

The development of current environmental problems raises the concerns of investors or hospital lenders about the potential financial problems resulting from current environmental problems. A sustainable health care system can achieve high-quality care and improve public health without wasting resources. The health service sector is continuously encouraged to apply the concept of "Green Hospital" which is one example of the continuity of health services. This research focuses on emission reduction management in health care facilities. This study examines several published papers containing the terms sustainable, green infrastructure, and energy management. Guidelines for Efficient and Sustainable Energy Management in Hospital Buildings is the selected article. The articles used were obtained from the Google Scholar database. Data analysis was carried out descriptively using tables. This study took data from three countries, namely Thailand, Taiwan, and Indonesia, based on our team's observations during a virtual hospital visit to the two countries (Thailand and Taiwan), which we then compared with most hospitals in Indonesia. Currently, there is no Green Hospital standard for each of these countries. The application of the green infrastructure concept can have a positive impact on cost efficiency and hospital sustainability. Energy Saving Opportunities (PHE) is one method that can be used to save energy use in hospitals. The way to do this is to control the use of infrastructure that consumes a lot of energy, such as the use of lights and Air Conditioners (AC), as well as other infrastructure that is not included in vital equipment.
ENVIRONMENTAL IMPACT ANALYSIS FOR HEALING MENTAL HEALTH PATIENT
Authors:   Postgraduate Program in Hospital Management Faculty of Medicine Universitas Brawijaya Malang Indonesia, Husada Unix Cahya , Louise Catharina ,   Postgraduate Program in Hospital Management Faculty of Medicine Universitas Brawijaya Malang Indonesia, Markes Anabella ,   Postgraduate Program in Hospital Management Faculty of Medicine Universitas Brawijaya Malang Indonesia, Saputro Dwi ,   Postgraduate Program in Hospital Management Faculty of Medicine Universitas Brawijaya Malang Indonesia, Bekti Asih Setyaning ,   Postgraduate Program in Hospital Management Faculty of Medicine Universitas Brawijaya Malang Indonesia, Andarini Sri ,   Department of Family Medicine Faculty of Medicine Universitas Brawijaya Malang Indonesia
Published: December 2022

Background : Mental health is a condition in which individuals can develop physically, mentally, spiritually, and socially so that they are aware of their abilities, can cope with pressure, work productively and are able to contribute to their community. According to the Indonesian Ministry of Health (2016), there are around 35 million people affected by depression, 60 million people affected by bipolar, 21 million affected by schizophrenia, and 47.5 million affected by dementia, psychosocial, religious, cultural and environmental. Several factors that affect mental health are social life, such as the family environment, school/work, and the social environment in general. Patients with mental health disorders have a calm tendency to be in a safe and comfortable environment. The physical environment for mental health patients is a safe and comfortable environment prepared to provide social impact for people with mental health conditions in hospitals. Facilities that must be prepared to support the healing environment process include privacy, social support, and a positive impact on the environment. This writing employs a literature review method related to the topic Environmental Impact Analysis for healing mental health patients. There are 14 journals used in this writing. The purpose of this paper is to analyze the environment that has an impact on the process of treating and healing patients with mental health disorders. Method : This study uses a literature review method related to the topic Environmental Impact Analysis for healing mental health patients . Literature review has an important role in making a scientific paper or essay, because it can provide ideas and goals about the research topic to be carried out which is about how the environmental impact for healing mental health patients. Conclusion : The social environment can be a source of mental health disorders, if not managed properly, as well as physical environmental factors. A well-managed social and physical environment can support healing . Health facilities as role models should apply the concept of a social environment and physical environment that supports and impacts on patient healing.
‘Where are the equal rights?’ Far-right women challenging gender equality and human rights in Greece
Authors: Anastasiadou Marianthi , Samara Jasmine
Published: December 2022

Across Europe, far-right groups balance between contradictory positions on gender equality, invoking women’s rights to claim European cultural superiority over imagined patriarchal Muslim immigrants while rejecting gender rights as threatening the nation. Using discourse analysis of online party media and parliamentary speeches, we explore intersections of gender and race in Greek neo-Nazi women’s public positioning towards gender equality, showing how these seemingly contradictory positions align well with the party’s political vision. At a moment of pervasive racist uses of feminist discourse (Farris 2017; Hark & Villa 2017), Golden Dawn women supported an antifeminist position that re-signifies ‘women’s rights’ as a racial issue, in order to construct political enemies and dismantle equality projects.  By representing gender violence  –  as in debates on the Istanbul Convention  –  as exclusively committed by the ‘non-white’‘Muslim’male, and by rejecting ‘artificially constructed’ equality rights in favor of ‘natural’ rights, they claimed Golden Dawn as the only political actor genuinely promoting women’s welfare.
Statistics in the Social Sciences : The Best of Two Worlds
Authors: van Duijn Marijtje
Published: December 2022

Hoe kun je statistiek gebruiken als brug tussen wetenschappelijke theorieën en onderzoeksdata? Deze vraag fascineert Marijtje van Duijn mateloos. Op 13 januari vertelt ze er meer over tijdens haar oratie in het Academiegebouw. Twee werelden Als statisticus binnen de vakgroep sociologie vormt Marijtje van Duijn de schakel tussen onderzoeksvragen en data. Van Duijn: “In onderzoek moeten de onderzoeksvraag en de statistische modellen uiteraard goed op elkaar aansluiten, maar het is ook belangrijk om te kijken in hoeverre de onderzoeksvraag met de data beantwoord wordt of kan worden”. Deze link tussen theorie en empirie staat dan ook centraal haar oratie. Sociale netwerkanalyse Van Duijns specialisatie is de zogeheten sociale netwerkanalyse, een methode die het mogelijk maakt om relaties tussen mensen te analyseren. “Bij sociologie wordt veel onderzoek naar sociale netwerken gedaan. De structuur van deze netwerken vereist een speciale aanpak, want een normale regressie analyse is niet mogelijk. Als groep zijn we de afgelopen twintig jaar heel hard bezig geweest met het ontwikkelen van methoden die recht doen aan de complexiteit van deze netwerken”. Puzzelen Statistische modellen voor sociale netwerkanalyse staan bekend als niet eenvoudig uit te voeren en te interpreteren, maar dat is juist wat van Duijn aantrekt. “Het zijn inderdaad soms ingewikkelde analyses. En ook de vraagstellingen zijn complex. Het is niet rechttoe rechtaan, maar het is een uitdagende puzzel. Ik vind het leuk om samen met de onderzoekers te kijken hoe we hun vragen zo goed mogelijk kunnen beantwoorden”.
User-Generated-Content and Millennial Moms' Birthplace Decision-Making Process
Authors: Ismail Farah Raihana , Jantan Amer Hamzah , Othman Norashida , Islam Md Asadul
Published: December 2022

Consumer reviews and experiences on UGC platforms are interoperable decision-making sources. Revolutionized UGC communication platform has changed millennial moms' birthplace decision-making process. They are rising concerns that UGC may lead to unsafe birth practices and risk the safety of the mother and baby. This preliminary qualitative study objective focused on exploring how other birth experiences shared over the UGC platform influence millennial moms' birthplace decisions. Preliminary findings identified two themes: verification and ratification and visibility and trustworthiness. The study provides in-depth information that aids policymakers, service providers, and marketers in understanding the millennial birthplace decision-making process from the consumers' perspective.
                                                                                                         Keywords: user-generated-content; decision-making process; experience; information search
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i22.4151
Culture Bites - A Reality of Food Truck Valley in Klang Valley Malaysia
Authors: Abdullah Norhidayah , Ishak Noriza , Saad Mazni , Abukhalifeh Alaa , Bujang Aisah
Published: December 2022

Cleanliness is an important element of customer satisfaction. This study aims to investigate the relationship between cleanliness attributes (product quality, food premise & food handlers' cleanliness) towards customers' hygiene satisfaction. An online survey was conducted among 116 customers in Klang Valley. The data were analyzed using SPSS Software version 26. Food premise, food handlers' cleanliness, and product quality are associated with customers’ hygiene satisfaction. Of all, food product quality was the most significant predictor. The results obtained may contribute to the cleanliness practices among food truck food handlers and as a basis for cleanliness practices for Malaysia Food Truck Association.
Keywords: Food truck; Cleanliness Attributes; Hygiene satisfaction
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i22.4154
Jobs, jobs, jobs: what’s an analyst to do?
Authors: Pickenpaugh Gavin C. , Adder Justin M.
Published: December 2022

Analysts and economists often face the task of using employment metrics to characterize industries of interest. Some key challenges can be understanding where to find employment metrics, the differences in various employment metrics, and when each metric should be used. This article analyzes a variety of publicly available employment data for the United States and compares these data. A detailed description of the intricacies of each data source is provided, which covers factors such as regionality, industry breakout, periodicity, and the types of jobs included. This article provides several case study examples, using the oil and gas extraction, coal mining, and chemical manufacturing sectors to portray challenges data users may face when developing employment estimates that suit their needs. Data users should be aware of a variety of data sources to understand alternative analysis options when data limitations are present and to determine which data source best meets their needs. Instances may occur in which information from one dataset may be used to help impute missing values.
Factors Influencing Adoption and Use of Telemedicine Services in Rural Areas of China: Mixed Methods Study
Authors: Du Yumeng , Zhou Qiru , Cheng Weibin , Zhang Zhang , Hoelzer Samantha , Liang Yizhi , Xue Hao , Ma Xiaochen , Sylvia Sean , Tian Junzhang , Tang Weiming
Published: December 2022

Background

The shortage of medical resources in rural China reflects the health inequity in resource-limited settings, whereas telemedicine could provide opportunities to fill this gap. However, evidence of patient acceptance of telemedicine services from low- and middle-income countries is still lacking.

Objective

We aimed to understand the profile of patient end-user telemedicine use and identify factors influencing telemedicine service use in rural China.

Methods

Our study followed a mixed methods approach, with a quantitative cross-sectional survey followed by in-depth semistructured interviews to describe telemedicine use and its associated factors among rural residents in Guangdong Province, China. In the quantitative analysis, explanatory variables included environmental and context factors, household-level factors, individual sociodemographic factors, access to digital health care, and health needs and demand factors. We conducted univariate and multivariate analyses using Firth logistic regression to examine the correlations of telemedicine uptake. A thematic approach was used, guided by the Social Cognitive Theory for the qualitative analysis.

Results

A total of 2101 households were recruited for the quantitative survey. With a mean age of 61.4 (SD 14.41) years, >70% (1364/2101, 72.94%) of the household respondents were male. Less than 1% (14/2101, 0.67%) of the respondents reported experience of using telemedicine. The quantitative results supported that villagers living with family members who had a fever in the past 2 weeks (adjusted odds ratio 6.96, 95% CI 2.20-21.98; P=.001) or having smartphones or computers (adjusted odds ratio 3.71, 95% CI 0.64-21.32; P=.14) had marginally higher telemedicine uptake, whereas the qualitative results endorse these findings. The results of qualitative interviews (n=27) also supplemented the potential barriers to telemedicine use from the lack of knowledge, trust, demand, low self-efficacy, and sufficient physical and social support.

Conclusions

This study found extremely low use of telemedicine in rural China and identified potential factors affecting telemedicine uptake. The main barriers to telemedicine adoption among rural residents were found, including lack of knowledge, trust, demand as well as low self-efficacy, and insufficient physical and social support. Our study also suggests strategies to facilitate telemedicine engagement in low-resource settings: improving digital literacy and self-efficacy, building trust, and strengthening telemedicine infrastructure support.
Leveraging Knowledge Graphs and Natural Language Processing for Automated Web Resource Labeling and Knowledge Mobilization in Neurodevelopmental Disorders: Development and Usability Study (Preprint)
Authors: Costello Jeremy , Kaur Manpreet , Reformat Marek Z , Bolduc Francois V
Published: December 2022

BACKGROUND

Patients and families need to be provided with trusted information more than ever with the abundance of online information. Several organizations aim to build databases that can be searched based on the needs of target groups. One such group is individuals with neurodevelopmental disorders (NDDs) and their families. NDDs affect up to 18% of the population and have major social and economic impacts. The current limitations in communicating information for individuals with NDDs include the absence of shared terminology and the lack of efficient labeling processes for web resources. Because of these limitations, health professionals, support groups, and families are unable to share, combine, and access resources.

OBJECTIVE

We aimed to develop a natural language–based pipeline to label resources by leveraging standard and free-text vocabularies obtained through text analysis, and then represent those resources as a weighted knowledge graph.

METHODS

Using a combination of experts and service/organization databases, we created a data set of web resources for NDDs. Text from these websites was scraped and collected into a corpus of textual data on NDDs. This corpus was used to construct a knowledge graph suitable for use by both experts and nonexperts. Named entity recognition, topic modeling, document classification, and location detection were used to extract knowledge from the corpus.

RESULTS

We developed a resource annotation pipeline using diverse natural language processing algorithms to annotate web resources and stored them in a structured knowledge graph. The graph contained 78,181 annotations obtained from the combination of standard terminologies and a free-text vocabulary obtained using topic modeling. An application of the constructed knowledge graph is a resource search interface using the ordered weighted averaging operator to rank resources based on a user query.

CONCLUSIONS

We developed an automated labeling pipeline for web resources on NDDs. This work showcases how artificial intelligence–based methods, such as natural language processing and knowledge graphs for information representation, can enhance knowledge extraction and mobilization, and could be used in other fields of medicine.
Growth and phytochemical properties in differences weight of porang bulbil (Amorphophallus muelleri B.) var. Madiun 1
Authors: Putri Widya Kristiyanti , Restanto Didik Pudji , Rusdiana Riza Yuli , Kriswanto Budi
Published: December 2022

The increase of Indonesian’s porang export has led into a new opportunity for better prosperity of local farmers. Thus, the demand for porang’s bulbil/ katak has risen due to its function for vegetative propagation. This study aimed to observe the growing and phytochemicals properties of porang tubers from bulbil with 10 bulbil weight categories samples, which were 0.5 g, 1 g, 1.5 g, 2 g, 2.5 g, 3 g, 3.5 g, 4 g, 4.5 g, and 5 g. The parameters observed were statistically analyzed in PAST 4.03. This study was conducted for three months and the results showed that samples from bulbil weighing 5 g had significant higher value than the others for the plant height, crown diameter, and stem diameter, but bulbil samples with other weights did not show any significant difference in porang tuber growth. Phytochemical’s analysis for dissolved protein resulting in 0.5 g weight sample was the best of all but random results for carbohydrate, antioxidants, polyphenol, and saponin.