bluuebunny/crossref_metadata_2025 huggingface dataset:
1,8-cineole ameliorates ischaemic brain damage via TRPC6/CREB pathways in rats
Authors: Meng Chen , Zeng Wenjing , Lv Jing , Wang Yu , Gao Meiling , Chang Ruijie , Li Qing , Wang Xianyu
Published: April 2021

Objectives

A previous in vitro study reported that the monoterpene oxide 1,8-cineole (cineole) attenuates neuronal caused by oxygen–glucose deprivation/reoxygenation in culture. However, to date, there is no in vivo evidence showing neuroprotective effects of cineole against stroke. This study aimed to investigate whether cineole attenuates cerebral ischaemic damage in rats.

Methods

A rat model of middle cerebral artery occlusion (MCAO) followed by 24 h reperfusion was applied. Male rats were treated with oral cineole (100 mg/kg) for 7 consecutive days, then subjected to MCAO surgery. Infarct volume, neurologic deficits, apoptosis and expression levels of all-spectrin breakdown products of 145 kDa (SBDP145), transient receptor potential canonical (subtype) 6 (TRPC6) and phosphorylated CREB (p-CREB) were measured in ischaemic brain tissues.

Key findings

Cineole treatment significantly reduced infarct volume, neurological dysfunction, neuronal apoptosis, SBDP145 formation and TRPC6 degradation and enhanced p-CREB expression in MCAO rats compared with vehicle treatment. These neuroprotective effects were markedly suppressed by pharmacological inhibition of MEK or CaMKIV signalling.

Conclusions

Our study provides in vivo evidence demonstrating that cineole pretreatment attenuates ischaemic stroke-induced brain damage, mainly through blocking calpain-induced TRPC6 degradation and activating CREB via MEK/CREB and CaMKIV/CREB signalling pathways.
India’s role in COVID-19 vaccine diplomacy
Authors: Sharun Khan , Dhama Kuldeep
Published: April 2021

Indian vaccine manufacturers such as Serum Institute of India, Bharat Biotech, Dr Reddy’s Laboratories, Biological E Limited, Aurobindo Pharma and Indian Immunologicals have already secured the license to manufacture major vaccine candidates. The ability of the country to manufacture cost-effective COVID-19 vaccines will help to meet the global vaccine requirements.
Curious Conversations: Henry Mayhew and the Street-Sellers in the Media Ecology of London Labour and the London Poor
Authors: Herdman Jenna M
Published: April 2021

Henry Mayhew is renowned as the chronicler and historian of London street-sellers and poor labourers. However, Mayhew’s relationships with his subjects, and their influence on the development of London Labour and the London Poor, is less often discussed. This article examines Mayhew’s productive and disruptive friendships, collaborations, and disagreements with the London poor, and situates these exchanges within the layered print and oral texts that comprise the extensive media ecology of London Labour. I argue that through their disruptive collaborations with Mayhew, some street-sellers, including Charles Alloway, memorialized as ‘The Crippled Street-Seller of Nut-Meg Graters’, strategically harnessed the media forms of London Labour for profitable self-representation. In contrast, a group of street-sellers known as the Street Traders’ Protection Association mobilized against Mayhew and critiqued his representations of their class. These disruptive collaborations reveal underlying kinships and conflicts between Mayhew and the street-folk, thus destabilizing his reputation as a neutral and authoritative observer in the history of poverty.
Magellanic satellites in ΛCDM cosmological hydrodynamical simulations of the Local Group
Authors: Santos-Santos Isabel M E , Fattahi Azadeh , Sales Laura V , Navarro Julio F
Published: April 2021

We use the APOSTLE ΛCDM cosmological hydrodynamical simulations of the Local Group to study the recent accretion of massive satellites into the halo of Milky Way (MW)-sized galaxies. These systems are selected to be close analogues to the Large Magellanic Cloud (LMC), the most massive satellite of the MW. The simulations allow us to address, in a cosmological context, the impact of the Clouds on the MW, including the contribution of Magellanic satellites to the MW satellite population, and the constraints placed on the Galactic potential by the motion of the LMC. We show that LMC-like satellites are twice more common around Local Group-like primaries than around isolated haloes of similar mass; these satellites come from large turnaround radii and are on highly eccentric orbits whose velocities at first pericentre are comparable with the primary’s escape velocity. This implies $V_{\rm esc}^{\rm MW} (50$ kpc) ∼ 365 km s−1, a strong constraint on Galactic potential models. LMC analogues contribute about two satellites with $M_*\gt 10^5\, \mathrm{ M}_\odot$, having thus only a mild impact on the luminous satellite population of their hosts. At first pericentre, LMC-associated satellites are close to the LMC in position and velocity, and are distributed along the LMC’s orbital plane. Their orbital angular momenta roughly align with the LMC’s, but, interestingly, they may appear to ‘counter-rotate’ the MW in some cases. These criteria refine earlier estimates of the LMC association of MW satellites: only the SMC, Hydrus1, Car3, Hor1, Tuc4, Ret2, and Phoenix2 are compatible with all criteria. Carina, Grus2, Hor2, and Fornax are less probable associates given their large LMC relative velocity.
I – A hydrodynamical clone of the Virgo cluster of galaxies to confirm observationally driven formation scenarios
Authors: Sorce Jenny G , Dubois Yohan , Blaizot Jérémy , McGee Sean L , Yepes Gustavo , Knebe Alexander
Published: April 2021

At ∼16–17 Mpc from us, the Virgo cluster is a formidable source of information to study cluster formation and galaxy evolution in rich environments. Several observationally driven formation scenarios arose within the past decade to explain the properties of galaxies that entered the cluster recently and the nature of the last significant merger that the cluster underwent. Confirming these scenarios requires extremely faithful numerical counterparts of the cluster. This paper presents the first clone, Constrained LOcal and Nesting Environment, simulation of the Virgo cluster within a ∼15 Mpc radius sphere. This cosmological hydrodynamical simulation, with feedback from supernovae and active galactic nuclei, with a ∼3 × 107 M⊙ dark matter particle mass and a minimum cell size of 350 pc in the zoom region, reproduces Virgo within its large-scale environment unlike a random cluster simulation. Overall the distribution of the simulated galaxy population matches the observed one including M87. The simulated cluster formation reveals exquisite agreements with observationally driven scenarios: within the last Gyr, about 300 small galaxies (M* > 107 M⊙) entered the cluster, most of them within the last 500 Myr. The last significant merger event occurred about 2 Gyr ago: a group with a tenth of the mass of today’s cluster entered from the far side as viewed from the Milky Way. This excellent numerical replica of Virgo will permit studying different galaxy type evolution (jellyfish, backsplash, etc.) as well as feedback phenomena in the cluster core via unbiased comparisons between simulated and observed galaxies and hot gas phase profiles to understand this great physics laboratory.
The SLUGGS survey: combining stars, globular clusters, and planetary nebulae to understand the assembly history of early-type galaxies from their large radii kinematics
Authors: Dolfi Arianna , Forbes Duncan A , Couch Warrick J , Bekki Kenji , Ferré-Mateu Anna , Romanowsky Aaron J , Brodie Jean P
Published: April 2021

We investigate the kinematic properties of nine nearby early-type galaxies with evidence of a disc-like component. Three of these galaxies are located in the field, five in the group, and only one in the cluster environment. By combining the kinematics of the stars with those of the globular clusters (GCs) and planetary nebulae (PNe), we probe the outer regions of our galaxies out to $\sim 4\!-\!6\, R_{\mathrm{e}}$. Six galaxies have PNe and red GCs that show good kinematic alignment with the stars, whose rotation occurs along the photometric major-axis of the galaxies, suggesting that both the PNe and red GCs are good tracers of the underlying stellar population beyond that traced by the stars. Additionally, the blue GCs also show rotation that is overall consistent with that of the red GCs in these six galaxies. The remaining three galaxies show kinematic twists and misalignment of the PNe and GCs with respect to the underlying stars, suggesting recent galaxy interactions. From the comparison with simulations, we propose that all six aligned galaxies that show similar dispersion-dominated kinematics at large radii ($\gt 2\!-\!3\, R_{\mathrm{e}}$) had similar late (z ≲ 1) assembly histories characterized by mini mergers (mass-ratio < 1:10). The different Vrot/σ profiles are then the result of an early (z > 1) minor merger (1:10 < mass-ratio < 1:4) for the four galaxies with peaked and decreasing Vrot/σ profiles and of a late minor merger for the two galaxies with flat Vrot/σ profiles. The three misaligned galaxies likely formed through multiple late minor mergers that enhanced their velocity dispersion at all radii, or a late major merger that spun-up both the GC subpopulations at large radii. Therefore, lenticular galaxies can have complex merger histories that shape their characteristic kinematic profile shapes.
The tidal stream generated by the globular cluster NGC 3201
Authors: Palau Carles G , Miralda-Escudé Jordi
Published: April 2021

We detect a tidal stream generated by the globular cluster NGC 3201 extending over ∼140 deg on the sky, using the Gaia DR2 data, with the maximum-likelihood method we presented previously to study the M68 tidal stream. Most of the detected stream is the trailing one, which stretches in the southern Galactic hemisphere and passes within a close distance of 3.2 kpc from the Sun, therefore making the stream highly favourable for discovering relatively bright member stars, while the leading arm is further from us and behind a disc foreground that is harder to separate from. The cluster has just crossed the Galactic disc and is now in the northern Galactic hemisphere, moderately obscured by dust, and the part of the trailing tail closest to the cluster is highly obscured behind the plane. We obtain a best-fitting model of the stream which is consistent with the measured proper motion, radial velocity, and distance to NGC 3201, and show it to be the same as the previously detected Gjöll stream by Ibata et al. We identify ∼200 stars with the highest likelihood of being stream members using only their Gaia kinematic data. Most of these stars (170) are photometrically consistent with being members of NGC 3201 when they are compared to the cluster H–R diagram, only once a correction for dust absorption and reddening by the Galaxy is applied. The remaining stars are consistent with being random foreground objects according to simulated data sets. We list these 170 highly likely stream member stars.
The spectra of IceCube neutrino candidate sources – I. Optical spectroscopy of blazars
Authors: Paiano Simona , Falomo Renato , Treves Aldo , Padovani Paolo , Giommi Paolo , Scarpa Riccardo
Published: April 2021

There is mounting evidence that ultra-energetic neutrinos of astrophysical origin may be associated with blazars. Here, we investigate a unique sample of 47 blazars, ∼20 of which could be new neutrino sources. In particular, we focus on 17 objects of yet unknown redshift, for which we present optical spectroscopy secured at the Gran Telescopio Canarias and the ESO Very Large Telescope. We find all sources but one (a quasar) to be BL Lac objects. For nine targets we are able to determine the redshift (0.09 < z < 1.6), while for the others we set a lower limit on it, based on either the robust detection of intervening absorption systems or on an estimation derived from the absence of spectral signatures of the host galaxy. In some spectra, we detect forbidden and semiforbidden emission lines with luminosities in the range 1040–1041 erg s−1. We also report on the spectroscopy of seven blazars possibly associated with energetic neutrinos that partially meet the criteria of our sample and are discussed in the Appendix. These results represent the starting point of our investigation into the real nature of these objects and their likelihood of being neutrino emitters.
The Hi-GAL compact source catalogue – II. The 360° catalogue of clump physical properties
Authors: Elia Davide , Merello M , Molinari S , Schisano E , Zavagno A , Russeil D , Mège P , Martin P G , Olmi L , Pestalozzi M , Plume R , Ragan S E , Benedettini M , Eden D J , Moore T J T , Noriega-Crespo A , Paladini R , Palmeirim P , Pezzuto S , Pilbratt G L , Rygl K L J , Schilke P , Strafella F , Tan J C , Traficante A , Baldeschi A , Bally J , Giorgio A M di , Fiorellino E , Liu S J , Piazzo L , Polychroni D
Published: April 2021

We present the 360° catalogue of physical properties of Hi-GAL compact sources, detected between 70 and 500 $\mu$m. This release not only completes the analogous catalogue previously produced by the Hi-GAL collaboration for −71° ≲ ℓ ≲ 67°, but also meaningfully improves it because of a new set of heliocentric distances, 120 808 in total. About a third of the 150 223 entries are located in the newly added portion of the Galactic plane. A first classification based on detection at 70 $\mu$m as a signature of ongoing star-forming activity distinguishes between protostellar sources (23 per cent of the total) and starless sources, with the latter further classified as gravitationally bound (pre-stellar) or unbound. The integral of the spectral energy distribution, including ancillary photometry from λ = 21 to 1100 $\mu$m, gives the source luminosity and other bolometric quantities, while a modified blackbody fitted to data for $\lambda \ge 160~\mu$m yields mass and temperature. All tabulated clump properties are then derived using photometry and heliocentric distance, where possible. Statistics of these quantities are discussed with respect to both source Galactic location and evolutionary stage. No strong differences in the distributions of evolutionary indicators are found between the inner and outer Galaxy. However, masses and densities in the inner Galaxy are on average significantly larger, resulting in a higher number of clumps that are candidates to host massive star formation. Median behaviour of distance-independent parameters tracing source evolutionary status is examined as a function of the Galactocentric radius, showing no clear evidence of correlation with spiral arm positions.
Resolved galactic superwinds reconstructed around their host galaxies at z > 3
Authors: Chen Mandy C , Chen Hsiao-Wen , Gronke Max , Rauch Michael , Broadhurst Tom
Published: April 2021

This paper presents a detailed analysis of two giant Lyman-alpha (Ly α) arcs detected near galaxies at z = 3.038 and z = 3.754 lensed by the massive cluster MACS 1206−0847 (z = 0.44). The Ly α nebulae revealed in deep MUSE observations exhibit a double-peaked profile with a dominant red peak, indicating expansion/outflowing motions. One of the arcs stretches over 1 arcmin around the cluster Einstein radius, resolving the velocity field of the line-emitting gas on kpc scales around three star-forming galaxies of 0.3–$1.6\, L_*$ at z = 3.038. The second arc spans 15 arcsec in size, roughly centred around two low-mass Ly α emitters of $\approx 0.03\, L_*$ at z = 3.754. All three galaxies in the z = 3.038 group exhibit prominent damped Ly α absorption (DLA) and several metal absorption lines, in addition to nebular emission lines such as $\hbox{He ii}$$\lambda \, 1640$ and C iii]λλ1906, 1908. Extended Ly α emission appears to emerge from star-forming regions with suppressed surface brightness at the centre of each galaxy. Significant spatial variations in the Ly α line profile are observed which, when unaccounted for in the integrated line, leads to biased constraints for the underlying gas kinematics. The observed spatial variations indicate the presence of a steep velocity gradient in a continuous flow of high column density gas from star-forming regions into a low-density halo environment. A detailed inspection of available galaxy spectra shows no evidence of AGN activity in the galaxies, and the observed Ly α signals are primarily explained by resonant scattering. The study presented in this paper shows that spatially resolved imaging spectroscopy provides the most detailed insights yet into the kinematics of galactic superwinds associated with star-forming galaxies.
A Chandra survey of z ≥ 4.5 quasars
Authors: Li Jiang-Tao , Wang Feige , Yang Jinyi , Bregman Joel N , Fan Xiaohui , Zhang Yuchen
Published: April 2021

X-ray observations provide a unique probe of the accretion disc corona of supermassive black holes (SMBHs). In this paper, we present a uniform Chandra X-ray data analysis of a sample of 152 z ≥ 4.5 quasars. We firmly detect 46 quasars of this sample in 0.5–2 keV above 3σ and calculate the upper limits of the X-ray flux of the remaining. We also estimate the power-law photon index of the X-ray spectrum of 31 quasars. 24 of our sample quasars are detected in the FIRST or NVSS radio surveys; all of them are radio-loud. We statistically compare the X-ray properties of our z ≥ 4.5 quasars to other X-ray samples of active galactic nuclei (AGNs) at different redshifts. The relation between the rest-frame X-ray luminosity and other quasar parameters, such as the bolometric luminosity, UV luminosity, or SMBH mass, shows large scatters. These large scatters can be attributed to the narrow luminosity range at the highest redshift, the large measurement error based on relatively poor X-ray data, and the inclusion of radio-loud quasars in the sample. The LX–LUV relationship is significantly sublinear. We do not find a significant redshift evolution of the LX–LUV relation, expressed either in the slope of this relation, or the departure of individual AGNs from the best-fitting αOX–LUV relation (ΔαOX). The median value of the X-ray photon index is Γ ≈ 1.79, which does not show redshift evolution from z = 0 to z ∼ 7. The X-ray and UV properties of the most distant quasars could potentially be used as a standard candle to constrain cosmological models. The large scatter of our sample on the Hubble diagram highlights the importance of future large unbiased deep X-ray and radio surveys in using quasars in cosmological studies.
Observational signatures of eccentric Jupiters inside gas cavities in protoplanetary discs
Authors: Baruteau Clément , Wafflard-Fernandez Gaylor , Le Gal Romane , Debras Florian , Carmona Andrés , Fuente Asunción , Rivière-Marichalar Pablo
Published: April 2021

Predicting how a young planet shapes the gas and dust emission of its parent disc is key to constraining the presence of unseen planets in protoplanetary disc observations. We investigate the case of a 2 Jupiter-mass planet that becomes eccentric after migrating into a low-density gas cavity in its parent disc. 2D hydrodynamical simulations are performed and post-processed by 3D radiative transfer calculations. In our disc model, the planet eccentricity reaches ∼0.25, which induces strong asymmetries in the gas density inside the cavity. These asymmetries are enhanced by photodissociation and form large-scale asymmetries in 12CO J=3→2 integrated intensity maps. They are shown to be detectable for an angular resolution and a noise level similar to those achieved in ALMA observations. Furthermore, the planet eccentricity renders the gas inside the cavity eccentric, which manifests as a narrowing, stretching and twisting of iso-velocity contours in velocity maps of 12CO J=3→2. The planet eccentricity does not, however, give rise to detectable signatures in 13CO and C18O J=3→2 inside the cavity because of low column densities. Outside the cavity, the gas maintains near-circular orbits, and the vertically extended optically thick CO emission displays a four-lobed pattern in integrated intensity maps for disc inclinations $\gtrsim$30○. The lack of large and small dust inside the cavity in our model further implies that synthetic images of the continuum emission in the sub-millimetre, and of polarized scattered light in the near-infrared, do not show significant differences when the planet is eccentric or still circular inside the cavity.
From starburst to quiescence: post-starburst galaxies and their large-scale clustering over cosmic time
Authors: Wilkinson Aaron , Almaini Omar , Wild Vivienne , Maltby David , Hartley William G , Simpson Chris , Rowlands Kate
Published: April 2021

We present the first study of the large-scale clustering of post-starburst (PSB) galaxies in the high-redshift Universe (0.5 < z < 3.0). We select ∼4000 PSB galaxies photometrically, the largest high-redshift sample of this kind, from two deep large-scale near-infrared surveys: the UKIDSS Ultra Deep Survey Data Release 11 and the Cosmic Evolution Survey. Using angular cross-correlation techniques, we estimate the halo masses for this large sample of PSB galaxies and compare them with quiescent and star-forming galaxies selected in the same fields. We find that low-mass, low-redshift (0.5 < z < 1.0) PSB galaxies preferentially reside in very high mass dark matter haloes (Mhalo > 1014 M⊙), suggesting that they are likely to be infalling satellite galaxies in cluster-like environments. High-mass PSB galaxies are more weakly clustered at low redshifts, but they reside in higher mass haloes with increasing look-back time, suggesting strong redshift-dependent halo downsizing. These key results are consistent with previous results, suggesting that two main channels are responsible for the rapid quenching of galaxies. While high-redshift (z > 1) galaxies appear to be quenched by secular feedback mechanisms, processes associated with dense environments are likely to be the key driver of rapid quenching in the low-redshift Universe (z < 1). Finally, we show that the clustering of photometrically selected PSBs is consistent with them being direct descendants of highly dust-enshrouded submillimetre galaxies, providing tantalizing evidence for the oft-speculated evolutionary pathway from starburst to quiescence.
Compton scattering in the optically thick uniform spherical corona around the neutron star in an X-ray binary in two conditions
Authors: Shi ChangSheng
Published: April 2021

We consider the Compton scattering in the optically thick uniform spherical corona around a neutron star in an X-ray binary. In the scattering, the low energy seed photons (0.1 ∼ 2.5 keV) are scattered in low energy electrons (2.5 ∼ 10 keV) in the corona in two conditions, i.e. initial seed photons are scattered in a whole corona and scattered in every layer of the corona that are supposed to be divided into many layers. When the same number of input seed photons, the same corona parameters, and the same energy distribution of all photons in the two conditions are considered, the approximately same number of output photons can be obtained, which means that there is approximately a transform invariance of layering the Comptonized corona. Thus the scattering in the layers of a multilayered corona is approximately equal to the scattering in the whole corona by dividing the whole corona into several layers. It means that Compton scattering for the initial seed photons scattered in a whole optically thick spherical corona with uniformly distributed electrons also can be considered as that the multiple Compton scatterings take place in the layers of a multilayered corona in order approximately, which can be used to explore some physical process in one part of a corona.
Vice and Virtue in Sikh Ethics
Authors: Singh Keshav
Published: April 2021

In recent years, there has been increasing interest in analytic philosophy that engages with non-Western philosophical traditions, including South Asian religions such as Hinduism, Buddhism, and Jainism. However, thus far, there has been (to my knowledge) no engagement with Sikhism, despite its status as a major world religion with a rich philosophical tradition. This paper is an attempt to get a start at analytic philosophical engagement with Sikh philosophy. My focus is on Sikh ethics, and in particular on the theory of vice and virtue that can be gleaned from Sikh scripture. According to this theory, the five major vices have a unified source in the vice of haumai. Haumai is a kind of false conception of oneself as singularly important, and correspondingly, a false conception of the world as revolving around oneself, as a world of objects there for one’s use. Vice, then, comes down to the failure to recognize the importance of others. The corresponding picture of virtue is that virtue consists in a recognition of the importance of others, through the recognition of an ultimate reality on which all are One. After reconstructing the Sikh theory of vice and virtue, I conclude with some comparative remarks on Sikh and Western ethics.
No validity without a theory—a critical look at subjective measures of consciousness
Authors: Skóra Zuzanna , Del Pin Simon Hviid , Derda Monika , Koculak Marcin , Rutiku Renate , Wierzchoń Michał
Published: April 2021

Michel (The mismeasure of consciousness: a problem of coordination for the perceptual awareness scale. Philos Sci 2019;86:1239–49) claims that the Perceptual Awareness Scale (PAS) faces the problem of coordination (also known as validity). We argue that his claim holds only under certain theoretical assumptions which need to be made explicit as these are likely not in line with the PAS proponents’ standpoint. We also call for terminological clarity, an example being the usage of ‘levels’ of consciousness. Precise terminology combined with an explicit reference to the chosen theoretical perspective is necessary conditions for making progress in consciousness research and the development of consciousness theories.
Pilot Randomized Clinical Trial of a Text Messaging-Based Intervention for Smoking Cessation Among Young People Experiencing Homelessness
Authors: Tucker Joan S , Linnemayr Sebastian , Pedersen Eric R , Shadel William G , Zutshi Rushil , DeYoreo Maria , Cabreros Irineo
Published: April 2021

Introduction

Smoking rates are alarmingly high among young people experiencing homelessness (YEH), yet there are no evidence-based cessation programs for this population. This paper presents results from a pilot evaluation of a text messaging-based smoking cessation treatment, as an adjunct to brief group cessation counseling, to improve abstinence rates among 18–25-year-old smokers experiencing homelessness. The goal of this study was to estimate effect sizes for a larger trial and it was not powered to detect group differences.

Aims and Methods

YEH smokers who had a working cell phone with them at recruitment were randomized to receive a group counseling session, nicotine patches, and written material on quitting (n = 37) or a similar program that also included a 6-week automated text messaging intervention (TMI) to provide ongoing support for quitting (n = 40). Smoking outcomes were evaluated through a 90-day follow-up.

Results

Seven-day point prevalence abstinence at 90-day follow-up was higher in the TMI condition than standard condition (17.50% vs. 8.11%, respectively; Cohen’s h = .37); however, the 90-day continuous abstinence rate was not statistically different from zero in either condition. Reductions in the number of days smoked in the past 30 days from baseline to follow-up were greater in the TMI condition than the standard condition (−14.24 vs. −8.62, respectively; Cohen’s d = .49).

Conclusions

Adding a 6-week TMI support to a brief group counseling and pharmacotherapy protocol holds promise for smoking reduction and abstinence among YEH smokers. Results indicate that further development and evaluation of the TMI in this population is warranted.

Trial Registration

ClinicalTrials.gov Identifier NCT03874585. Registered March 14, 2019, https://clinicaltrials.gov/ct2/show/record/NCT03874585.

Implications

This is the first study to evaluate the feasibility of using a text messaging-based intervention (TMI) for behavior change with 18–25 year olds experiencing homelessness, and more specifically, the first to test a TMI to provide ongoing support for smoking cessation. Small to medium effect sizes for the TMI are promising in terms of implementing a TMI using participants’ own cell phones, as well as the efficacy of this approach as an adjunct to standard care (brief group counseling and pharmacotherapy) for smoking cessation among YEH.
E-Cigarette Advertising in the UK: A Content Analysis of Traditional and Social Media Advertising to Observe Compliance with Current Regulations
Authors: Stead Martine , Ford Allison , Angus Kathryn , MacKintosh Anne Marie , Purves Richard , Mitchell Danielle
Published: April 2021

Introduction

The advertising of e-cigarettes in the UK is regulated through the revised EU Tobacco Products Directive and the Tobacco and Related Products Regulations, with further rules set out in the Advertising Standards Authority (ASA) Committees of Advertising (CAP) Code. Focusing on the ASA CAP Code Rules, we examined e-cigarette advertising regulation compliance in traditional advertising channels and on social media.

Methods

We conducted a content analysis of UK e-cigarette and related product advertising using a randomly selected sample (n = 130) of advertising in traditional channels and on Instagram which appeared between January and December 2019. All ads were independently double-coded to assess compliance with each CAP Code Rule.

Results

In traditional channels, our sample of advertising had largely good compliance. Only very small numbers of these ads appeared to be clearly in breach of any of the ASA rules (5% were in breach of Rule 22.7; 2% of Rule 22.9; and 1% of Rule 22.10). In contrast, we judged that all of the Instagram sample (n = 30) was in breach of Rule 22.12. For some rules, it was not possible to make definitive judgments about compliance, given uncertainty regarding how a rule should be interpreted and applied.

Conclusions

We found overall good compliance for advertising in traditional channels, but assessed all of our social media advertising samples was in breach of regulations. Current guidance on e-cigarette advertising could be improved to facilitate e-cigarette advertising assessment and regulation. It would be beneficial to bring consumer perspectives into the assessment of regulation compliance.

Implications

The regulation of e-cigarette advertising is a global concern. The UK Government has a statutory obligation to review the Tobacco and Related Products Regulations by May 2021. This study assessed compliance with current UK e-cigarette advertising regulations on placement and content. We identified areas where greater clarity is needed and outlined implications for future regulation.
Seasonal variation of growth and reproduction of the subarctic krill species, Thysanoessa raschii, driven by environmental conditions in the Estuary and Gulf of St. Lawrence
Authors: Cope Laurie Emma , Plourde Stéphane , Winkler Gesche
Published: April 2021

The aim of this study was to quantify somatic growth and reproduction of Thysanoessa raschii in response to environmental conditions in the St. Lawrence Estuary and Gulf of St. Lawrence, Canada. We sampled between 2010 and 2016 from spring to late summer and incubated individuals. Fresh molts were collected daily and measured to calculate the growth increment following the instantaneous growth rate method while eggs were counted daily. Our results showed a seasonal pattern of somatic growth and reproduction driven by temperature and chl. a concentration with a decrease in somatic growth in August when egg production was maximal, suggesting a trade-off. Functional relationship analyses revealed a narrow optimal temperature window for somatic growth with maximum temperatures observed between 1.2 and 2.0°C in the cold intermediate layer (50–150 m). Maximum egg production was observed at temperatures between 3.8 and 5.7°C in the surface layer (0–50 m). A required minimum concentration of chl. a of 9 mg.m−3 for somatic growth was observed. For egg production, the minimum observed was integrated chl. a (0–50 m) of 80 mg.m−2. We also observed the importance of optimal conditions lasting for one to 3 weeks to support biological processes in T. raschii.
HEAT SHOCK PROTEIN 90 proteins and YODA regulate main body axis formation during early embryogenesis
Authors: Samakovli Despina , Tichá Tereza , Vavrdová Tereza , Závorková Natálie , Pecinka Ales , Ovečka Miroslav , Šamaj Jozef
Published: April 2021

The YODA (YDA) kinase pathway is intimately associated with the control of Arabidopsis (Arabidopsis thaliana) embryo development, but little is known regarding its regulators. Using genetic analysis, HEAT SHOCK PROTEIN 90 (HSP90) proteins emerge as potent regulators of YDA in the process of embryo development and patterning. This study is focused on the characterization and quantification of early embryonal traits of single and double hsp90 and yda mutants. HSP90s genetic interactions with YDA affected the downstream signaling pathway to control the development of both basal and apical cell lineage of embryo. Our results demonstrate that the spatiotemporal expression of WUSCHEL-RELATED HOMEOBOX 8 (WOX8) and WOX2 is changed when function of HSP90s or YDA is impaired, suggesting their essential role in the cell fate determination and possible link to auxin signaling during early embryo development. Hence, HSP90s together with YDA signaling cascade affect transcriptional networks shaping the early embryo development.
The function of glutaredoxin GRXS15 is required for lipoyl-dependent dehydrogenases in mitochondria
Authors: Moseler Anna , Kruse Inga , Maclean Andrew E , Pedroletti Luca , Franceschetti Marina , Wagner Stephan , Wehler Regina , Fischer-Schrader Katrin , Poschet Gernot , Wirtz Markus , Dörmann Peter , Hildebrandt Tatjana M , Hell Rüdiger , Schwarzländer Markus , Balk Janneke , Meyer Andreas J
Published: April 2021

Iron–sulfur (Fe–S) clusters are ubiquitous cofactors in all life and are used in a wide array of diverse biological processes, including electron transfer chains and several metabolic pathways. Biosynthesis machineries for Fe–S clusters exist in plastids, the cytosol, and mitochondria. A single monothiol glutaredoxin (GRX) is involved in Fe–S cluster assembly in mitochondria of yeast and mammals. In plants, the role of the mitochondrial homolog GRXS15 has only partially been characterized. Arabidopsis (Arabidopsis thaliana) grxs15 null mutants are not viable, but mutants complemented with the variant GRXS15 K83A develop with a dwarf phenotype similar to the knockdown line GRXS15amiR. In an in-depth metabolic analysis of the variant and knockdown GRXS15 lines, we show that most Fe–S cluster-dependent processes are not affected, including biotin biosynthesis, molybdenum cofactor biosynthesis, the electron transport chain, and aconitase in the tricarboxylic acid (TCA) cycle. Instead, we observed an increase in most TCA cycle intermediates and amino acids, especially pyruvate, glycine, and branched-chain amino acids (BCAAs). Additionally, we found an accumulation of branched-chain α-keto acids (BCKAs), the first degradation products resulting from transamination of BCAAs. In wild-type plants, pyruvate, glycine, and BCKAs are all metabolized through decarboxylation by mitochondrial lipoyl cofactor (LC)-dependent dehydrogenase complexes. These enzyme complexes are very abundant, comprising a major sink for LC. Because biosynthesis of LC depends on continuous Fe–S cluster supply to lipoyl synthase, this could explain why LC-dependent processes are most sensitive to restricted Fe–S supply in grxs15 mutants.
Classical phenotyping and deep learning concur on genetic control of stomatal density and area in sorghum
Authors: Bheemanahalli Raju , Wang Chaoxin , Bashir Elfadil , Chiluwal Anuj , Pokharel Meghnath , Perumal Ramasamy , Moghimi Naghmeh , Ostmeyer Troy , Caragea Doina , Jagadish S.V. Krishna
Published: April 2021

Stomatal density (SD) and stomatal complex area (SCA) are important traits that regulate gas exchange and abiotic stress response in plants. Despite sorghum (Sorghum bicolor) adaptation to arid conditions, the genetic potential of stomata-related traits remains unexplored due to challenges in available phenotyping methods. Hence, identifying loci that control stomatal traits is fundamental to designing strategies to breed sorghum with optimized stomatal regulation. We implemented both classical and deep learning methods to characterize genetic diversity in 311 grain sorghum accessions for stomatal traits at two different field environments. Nearly 12,000 images collected from abaxial (Ab) and adaxial (Ad) leaf surfaces revealed substantial variation in stomatal traits. Our study demonstrated significant accuracy between manual and deep learning methods in predicting SD and SCA. In sorghum, SD was 32%–39% greater on the Ab versus the Ad surface, while SCA on the Ab surface was 2%–5% smaller than on the Ad surface. Genome-Wide Association Study identified 71 genetic loci (38 were environment-specific) with significant genotype to phenotype associations for stomatal traits. Putative causal genes underlying the phenotypic variation were identified. Accessions with similar SCA but carrying contrasting haplotypes for SD were tested for stomatal conductance and carbon assimilation under field conditions. Our findings provide a foundation for further studies on the genetic and molecular mechanisms controlling stomata patterning and regulation in sorghum. An integrated physiological, deep learning, and genomic approach allowed us to unravel the genetic control of natural variation in stomata traits in sorghum, which can be applied to other plants.
‘Scaling’ the academia: Perspectives of academics on the impact of their practices
Authors: Kondakci Yasar , Zayim-Kurtay Merve , Kaya-Kasikci Sevgi , Senay Hanife Hilal , Kulakoglu Busra
Published: April 2021

The pressure on the universities to take a visible place in the rankings has caused anachronistic policies and practices in evaluating the performance of universities. The value attributed to the rankings results in policies prioritizing the criteria imposed by rankings while evaluating the performance of academics, which successively causes several issues in assessing the real impact of the academic practices. Considering these criticisms and concerns about the impact assessment, this study aimed at exploring the perceptions of academics about the impact of their academic practices. Adapting the interpretive phenomenological design, the data were collected through semi-structured interviews with 20 participants from the field of education in five flagship universities of Turkey. The findings of the study revealed that, although impact assessment understanding of the academics and their institutions go parallel with covering the practices around three basic missions of the university, many activities go in between without recognition by the same impact assessment practices. Interestingly, the academics exhibited their commitment to institutional policies in impact assessment practices; however, they exhibit resentment for the same policies due to failing to recognize the localized mission of the university, threatening the deeply rooted values of the academy, fouling the academy with ethical violations, and causing further detachment between academic practices and societal needs. The concerns and criticism of the current impact assessment are likely to alter the priorities of the universities and push them to adapt an impact assessment, which is less relevant to the local needs of their societies.
Asset Price Dynamics with Limited Attention
Authors: Hendershott Terrence , Menkveld Albert J , Praz Rémy , Seasholes Mark
Published: April 2021

We identify long-lived pricing errors through a model in which inattentive investors arrive stochastically to trade. The model’s parameters are structurally estimated using daily NYSE market-maker inventories, retail order flows, and prices. The estimated model fits empirical variances, autocorrelations, and cross-autocorrelations among our three data series from daily to monthly frequencies. Pricing errors for the typical NYSE stock have a standard deviation of 3.2 percentage points and a half-life of 6.2 weeks. These pricing errors account for 9.4$\%$, 7.0$\%$, and 4.5$\%$ of the respective daily, monthly, and quarterly idiosyncratic return variances.
COMPARISON OF CONVENTIONAL HAND EXAMINATION ON SIX OPTIMISED DR SYSTEMS
Authors: Precht Helle , Outzen Claus Bjørn , Kusk Martin Weber , Bisgaard Malene , Waaler Dag
Published: April 2021

The purpose of this study was to investigate the challenges in comparing digital radiography (DR) systems from different vendors for various combinations of exposure factors in posterior–anterior hand radiographs. Image quality was evaluated for a range of tube voltages and tube current-time products using a technical contrast-detail (CDRAD) phantom and an anthropomorphic hand phantom. 900 technical CDRAD images were analysed providing quality figures of merit (IQFinv) and two experienced reporting radiographers using visual grading analysis (VGA) scored 108 anthropomorphic images. This study demonstrates the differences between the DR systems included. When compensating for variations in dose, Canon showed superior results for technical image quality and Fuji for visual image quality for a standard dose point at DR hand examination (ln(DAP) 1.1, 50 kV and 2.5 mAs).
Pulmonary Mycobacterium abscessus Infection in an 11-Year-Old Child, Successfully Treated with Inhaled/Parenteral Amikacin: A Case Report and Review of Literature
Authors: Deniz Melis , Ramaslı Gursoy Tugba , Tapısız Anıl , Tezer Hasan , Aslan Ayse Tana
Published: April 2021

Mycobacterium abscessus appears to be increasing cause of pulmonary infection in children with underlying risk factors including cystic fibrosis, chronic lung disease and immunodeficiency syndromes. We present a case of pulmonary M. abscessus infection in a pediatric patient with primary ciliary dyskinesia and he was successfully treated with parenteral amikacin, linezolid and oral clarithromycin combined with inhaled amikacin. Clinical improvement was observed after adding inhaled amikacin to the treatment.
Physical Growth and Neurodevelopment of a Cohort of Children after 3.5 Years of Follow-up from Mothers with Zika Infection during Pregnancy—Third Report of the ZIKERNCOL Study
Authors: Cardona-Ospina Jaime A , Zapata María Fernanda , Grajales Manuela , Arias María Alejandra , Grajales Jennifer , Bedoya-Rendón Héctor D , González-Moreno Gloria M , Lagos-Grisales Guillermo J , Suárez José Antonio , Rodríguez-Morales Alfonso J
Published: April 2021

Introduction

In utero Zika virus (ZIKV) exposure has been related to a group of congenital structural abnormalities called the congenital Zika syndrome, which also has been related to neurodevelopment alterations even in normocephalic children. Physical growth has been less explored, and delayed growth and malnutrition have been reported.

Objective

The objective of this study is to describe the growth and neurodevelopment features of normocephalic infants born from a cohort of mothers with RT-PCR confirmed ZIKV during pregnancy in Risaralda, Colombia.

Methods

We conducted a retrospective cohort, including normocephalic children born from mothers with RT-PCR confirmed ZIKV infection during pregnancy in Risaralda, Colombia. Physical growth was measured using WHO standards, and neurodevelopment was measured with the abbreviated neurodevelopment scale 2 validated for Colombia.

Results

After verifying inclusion and exclusion criteria, 16 children were followed during a median time of 28 months (IQR 23–31 months); for a total of 116 visits, 87.5% (n = 14) of the patients developed a growth alteration. Five presented post-natal microcephaly, and among them, four presented malnutrition or low height. Six patients developed macrocephaly. Patients with a normal head circumference had normal neurodevelopment. Only one patient with microcephaly persisted with impairment of the neurodevelopment at the end of follow-up. All the patients with macrocephaly had normal neurodevelopment.

Discussion

Our study suggests that growth could be altered in infants with in utero Zika exposure. We found a high proportion of patients with overgrowth and macrocephaly. Future studies should consider endocrine follow-up of children born with in utero Zika exposure to explore these findings’ possible aetiologies.

Conclusion

We found a high proportion of growth alterations, particularly with overgrowth features and macrocephaly. Our study suggests that in addition to neurodevelopment impairment, growth could be altered in infants and children with in utero Zika exposure, even in those patients born without CZS.
Comparison of 3 C-Arm Draping Techniques to Prevent Far Side Contamination
Authors: Romano David M. , Hautala Gavin S. , Abbenhaus Eric J. , Aneja Arun , Moghadamian Eric S. , Wright Raymond D. , Sciadini Marcus F. , Matuszewski Paul E.
Published: April 2021

Objective:

To assess the effectiveness of reducing contamination using 2 methods of C-Arm draping compared with traditional methods.

Materials and Methods:

The authors simulated an operating room using an extremity drape, commercially available C-Arm drapes, and C-Arm. A black light was placed above the field. A fluorescent powder was placed on the nonsterile portions of the field. Baseline light intensity was recorded by photo. The C-Arm was brought into the surgical field for orthogonal imaging for 15 cycles. A repeat photograph was taken to measure the increase in intensity of the fluorescent powder to assess degree of contamination. This was repeated 5 times for each configuration: standard C-Arm drape, a proprietary close-fitting drape, and a split drape secured to the far side with the split wrapped around the C-Arm receiver. Light intensity difference was measured and average change in intensity was compared.

Results:

Compared with standard draping, the proprietary close-fitting drape resulted in a 71.3% decrease in contamination (4.84% vs. 16.90%, P = 0.101) that trended toward significance and the split drape resulted in a 99.5% decrease (0.09% vs. 16.90%, P = 0.017) that was statistically significant.

Conclusion:

Far side contamination can be reduced by using a split drape connecting the operative table to the C-Arm receiver, effectively “sealing off” contaminants. The proprietary close-fitting drape may also decrease contamination, but this was not statistically significant in this study. Use of the split drape technique will help prevent contamination and may ultimately lead to decreased infection risk.