bluuebunny/crossref_metadata_2025 huggingface dataset:
MEMAHAMI PERILAKU KETIDAKPATUHAN PENGGUNAAN OBAT DI KALANGAN PENDERITA PENYAKIT HIPERTENSI: APLIKASI TEORI HEALTH BELIEF MODEL
Authors: Sumiyem Sr. M. Karla , Agustina Reni , Nugrahanto Ignasius Andika , Jati Yohana Gita Sasmaya , Hadijaya Gladys Larasati
Published: October 2023

Hypertension disease is one of the risk factors for cardiovascular and blood vessel disease which is increasing constantly through the world and it is the main cause of premature death. Currently, the therapy that used for hypertension is antihypertensive treatment and applying the healthy lifestyle. Adherence in using antihypertensive medications is very important to achieve controlled hypertension. However, there are many nonadherence behaviors in the use of drugs that can cause a decrease in the patient’s quality of life. This study aimed to explore factors related to patient’s adherence in antihypertensive medications using Health Belief Model theory. This research is a qualitative study through deep interviews with open-ended questions. Respondents were all hypertension patients with minimum 3 months treatment of antihypertensive medications. Interviews were conducted using an interview guide compiled based on HBM constructs. Data were analyzed with content analysis. Result: 34 respondents were interviewed. Most respondents have high adherence in antihypertensive treatment 62% and 38% respondents have low adherence. This behavior is influenced by the low perception of susceptibility and severity to hypertension, which is caused by a lack patient knowledge. In addition, the high perception of barrier and the lack of perceived benefits when taking medication regularly also affects the level of patient nonadherence. Conclusion: Nonadherence behavior to antihypertensive medications was noticed in 38% of the respondents studied. Interventions strategies aiming to improve adherence can be done through patient education and using the electronic reminders.
The Morphological Analysis of Inflectional Plural Noun Suffixes Found in Catharsis Novel by Anastasia Aemelia
Authors: Laksmi I G A Mas Chandra Paramita , Tustiawati Ida Ayu Mela
Published: October 2023

Novel is a long narrative story that describes the specific human experiences in their life as depicted by the portrait of the characters. A novel that is written by Anastasia Aemilia entitled Catharsis talks about the story of a troubled young woman with special gifts and heavy burdens. Observing inflectional suffix aims to enrich the language learners’ vocabulary especially noun in plural forms. This qualitative research focuses on the analysis of inflectional plural noun suffixes that are found in the novel entitled Catharsis. This study is also analyzed based on the theory that proposed by Katamba (1993) regarding to the research problem which about the types of inflectional plural noun suffix. The results that are found 681 data that contain inflectional suffixes. Those data are divided into 3 categories namely 646 data (95%) of plural noun suffix (-s), 28 data (4%) of plural noun suffix (-es), and 7 data (1%) of plural suffix (-ies).
Three cases of GERD treated by endoscopic cardiac constriction in Tibetan District County Hospital
Authors: Gesang Wangdui , Solang Baima , Li Li , Ci Yang , Ciren Luobu , Ciren Luobu , Zhu Ying
Published: October 2023

Gastroesophageal reflux disease (GERD) is a common disease in the outpatient clinic. The symptoms of GERD are typical heartburn, acid reflux and chest pain, and a few are accompanied by extra-esophageal symptoms, such as cough. The recurrence rate of gastroesophageal reflux disease (GERD) is high in medical treatment. Three patients with gastroesophageal reflux disease who failed to receive standard medical treatment were treated by endoscopic cardiac coachectomy in the secondary hospital of Chayu County, Tibet Autonomous Region.
Expérience des réfugiés, demandeurs d’asile et migrants sans statut et offre de services de santé et sociaux pendant la pandémie au Québec
Authors: Gautier Lara , Bentayeb Naïma
Published: October 2023

À l’échelle mondiale, la pandémie de la COVID-19 a affecté de manière disproportionnée les migrants en termes de risque d’infection, de santé mentale, de processus d’immigration et d’accès aux services de santé et sociaux et aux ressources de soutien. Face à la COVID-19, les organismes communautaires et les établissements du réseau public de services de santé et services sociaux du Québec ont réagi en adaptant leurs pratiques et en offrant davantage de services à distance. Ils ont joué un rôle central dans la prévention et le traitement des infections à la COVID-19 et ils ont oeuvré en matière de protection sociale. Ce numéro thématique offre une réflexion approfondie des chercheurs de l’Institut universitaire SHERPA de Montréal sur les expériences des migrants pendant la pandémie de COVID-19 au Québec et sur la valorisation d’innovations dans les services communautaires et institutionnels mises en oeuvre.
La position sociale : un déterminant révélateur de l’expérience des personnes migrantes sans assurance médicale à Montréal durant la pandémie de COVID-19
Authors: Dufour Andréanne , Beaujoin Camille , Gagnon-Dufresne Marie-Catherine , Cloos Patrick
Published: October 2023

Selon les plus récentes estimations, la Loi sur l’assurance maladie laisse 50 000 à 70 000 migrants sans assurance médicale au Québec. L’accès aux soins de santé dans la province canadienne est, entre autres, lié au statut migratoire. Avant la pandémie, diverses barrières à l’accès aux soins (administratives, économiques, linguistiques, culturelles, etc.) avaient été identifiées. En tant que déterminant social de la santé, l’accès discriminatoire aux soins de santé nuit à la santé de ces migrants. Dans le contexte de la crise sanitaire liée à la COVID-19, les inégalités sociales en santé ont semblé s’intensifier pour les personnes issues des diverses communautés migrantes vivant à Montréal et ailleurs dans le monde. Grâce à un projet de recherche qualitatif, nous explorons dans cet article comment la position sociale, en particulier le statut migratoire, se traduit dans l’expérience vécue pendant la pandémie de COVID-19 pour les personnes migrantes sans assurance médicale vivant à Montréal. Pour atteindre cet objectif, nous avons mené des entretiens semi-structurés auprès de 19 personnes lors de la première et de la deuxième vague de pandémie (août 2020 à octobre 2020). Nos résultats suggèrent que le statut migratoire, à l’intersection avec le revenu, les conditions de travail et les rapports de genre, joue un rôle déterminant sur l’expérience vécue des participants avant et pendant la pandémie. Cela met en lumière l’urgence de mettre en place des politiques publiques plus inclusives pour assurer l’accès à l’aide sociale et à l’assurance médicale afin de remédier aux inégalités sociales en santé auxquelles sont confrontées les personnes migrantes sans assurance médicale vivant au Québec.
« Peu importe les vagues, la porte a toujours été ouverte ». Aperçu des activités de l’équipe de santé des réfugiés de Québec
Authors: Trosseille Noémie , Azri Mehdi , Coulibaly Gneninfolo Lazar , Gagnon Mélanie M.
Published: October 2023

La pandémie de COVID-19 a eu de nombreux impacts sur les personnes réfugiées pour de nombreuses raisons : elles sont plus à risque de contracter la COVID-19 et de la transmettre (par exemple : forte représentativité dans les services essentiels, conditions de logement et utilisation des transports en commun), elles ont vu leur santé mentale fragilisée en raison des effets de certaines mesures sanitaires (par exemple : isolement social, résurgence de traumatismes passés, difficultés d’accès à des banques alimentaires). Cette population étant reconnue pour son moindre accès aux services de santé et sociaux, il importe de considérer, en contexte de pandémie, que la situation des personnes réfugiées devient un enjeu de santé publique. À leur arrivée au Québec, les personnes réfugiées réinstallées bénéficient d’une évaluation de leur bien-être et de leur état de santé physique, offerte par les équipes de santé des réfugiés dans chacune des 14 villes d’accueil de la province. Dans le contexte de la COVID-19, ces équipes de santé des réfugiés ont dû réajuster leurs activités puisque les arrivées de personnes réfugiées ont été suspendues. Cet article présente une analyse exploratoire des réflexions et des actions spécifiques de l’équipe de santé des réfugiés de la ville de Québec, qui a affiché une diversité d’initiatives. Les quatre entrevues semi-dirigées auprès de professionnelles de l’équipe visaient à documenter les changements amenés par la pandémie dans les activités de l’équipe. Les participantes ont expliqué s’être basées sur leur expérience auprès de cette population pour mettre en place des appels téléphoniques à visée préventive, tant sur les plans de la COVID-19 que des défis psychosociaux. Elles ont également collaboré avec les organismes et la direction de santé publique afin d’organiser la vaccination contre la COVID-19 à même leurs locaux. Finalement, elles ont assuré un mandat élargi auprès des personnes migrantes à statut précaire.
How did support systems in Western countries transform and adapt to meet underserviced and marginalized migrants' needs? A scoping review
Authors: Borvil Achille Dadly , Gautier Lara
Published: October 2023

Prior studies on the impacts of the COVID-19 pandemic on migrants with precarious immigration status (refugees, asylum seekers, and undocumented migrants who arrived in a host country fewer than five years ago) have shown that they have been disproportionately affected by the pandemic because of their migration and socioeconomic status. Across the world, support systems for these marginalized migrants at local levels had to be reinvented to face the pandemic and ensure continuity of services. The objective of this systematic review was to provide a portrait of the interventions that were set up to address underserviced and marginalized migrants’ needs in Western countries during the pandemic and to categorize them by area of intervention. We identified peer-reviewed papers published in English and French between March 2020 and February 2022 in MEDLINE, Embase, PubMed and Web of Science. We included original research studies, commentaries, essays and editorials. For grey literature, we searched in Google Scholar and the websites of major health organizations and institutions that worked with underserviced and marginalized migrants. We also consulted the articles’ list of references. We included 31 publications: 15 peer-reviewed articles and 16 grey literature documents. Our results indicated that in order to address vulnerable newcomers’ needs, support systems intervened in the following areas: immigration, health and social services; raising awareness about COVID-19, food security, primary and secondary basic needs; and mental health and control of COVID-19 infection in settings with high concentrations of underserviced and marginalized migrants. Selected interventions adopted a collaborative approach between actors in different sectors. Most of the interventions were carried out by community-based organizations. Our scoping review highlights the role of community-based organizations in improving the living conditions of migrants with precarious immigration status during the pandemic and emphasizes the relevance of intersectoral collaboration as a strategy to respond effectively to the needs of underserviced and marginalized migrants in times of crisis.
Qui suis-je ? Quelle(s) case(s) cocher ? Catégorisation au sein des organisations : une recherche sur les tensions entre l’assignation de l’identité et l’invisibilisation des expériences
Authors: Mbengue-Reiver Marie-Andrée , Garakani Tatiana , Nzobonimpa Stany
Published: October 2023

Le besoin de catégoriser les individus afin de concevoir, mettre en oeuvre et évaluer les effets des programmes se confronte d’une part à la multiplicité des identités des individus et d’autre part aux stratégies des individus afin d’éviter une assignation identitaire qui ne corresponde pas, complètement ou en partie, à la réalité de leurs expériences. En employant un cadre d’analyse intersectionnelle, nous documentons les distorsions entre l’auto-identification et la catégorisation d’un échantillon de répondants travaillant dans divers secteurs d’activité. Cette recherche s’inscrit plus largement dans le cadre d’un projet-pilote sur l’expérience d’inclusion dans les organisations. Cet article aborde la nécessité de considérer la multiplicité, la fluidité et l’intersection des identités ainsi que la complexité de la réalité sociale, afin de repenser l’ingénierie de la diversité et dans le but d’étudier les discriminations et les inégalités à partir de l’expérience et des identités vécues des individus.
Systemic isotretinoin treatment and pregnancy: A comparative study of two groups of women: A retrospective analysis of 569 women
Authors: Brzezinski Piotr , Katarzyna Borowska , Anca Chiriac , Janusz Smigielski
Published: October 2023

Background: Oral isotretinoin is the only drug which promotes prolonged remission or cure of severe acne. The aim of our study was to estimate the isotretinoin exposure and to evaluate the effectiveness of the Polish and Romanian pregnancy prevention. This is a comparative study of two groups of women. Methods: A retrospective, comparative study of 569 women with acne vulgaris. The study included two groups of randomly selected women during treatment and follow-up. Group I with rigorous prevention of pregnancy; Group II without this rigor. Results: We did not register any pregnancies. 1.93% used oral contraceptives, 92.79% used a condom during sex, and 7.21% of women abstained from sex. The analysis showed significant differences (p <0.0001) total dose applied depending on the method of treatment. No statistically significant correlations were found between patients' age, duration of disease, location, and type of acne. Average length of therapy was 8.81 months. Isotretinoin therapy was interrupted for 27 patients from group I. Conclusion: The isotretinoin pregnancy prevention in Poland and Romania was very good during our study. Every woman in the fertile phase of life should use contraception while taking isotretinoin. The most important thing is the awareness of the patient.
Perlemakan Hati Non-Alkoholik dan Risiko Fibrosis Hati pada Pasien Hepatitis B Kronik
Authors:   Divisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia, RSUPN Cipto Mangunkusumo, Jakarta, Indonesia., Sulaiman Andri Sanityoso
Published: October 2023

Introduction. Prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing throughout the world due to sedentary lifestyle and dietary habit, including in patients with chronic hepatitis B (CHB). In several studies, advanced of liver disease were more likely observed among those CHB patients with NAFLD. NAFLD might increase the risk of liver disease progression in CHB patients, but prior investigations were still limited. This study aimed to determine the association between NAFLD and risk of liver fibrosis in CHB patients. Methods. All patients with positive serum hepatitis B surface antigen in the Hepatobilier Data Registry, Cipto Mangunkusumo Hospital, were included in this study. Based on abdominal ultrasonography, patients were divided into two group (group I: non-NAFLD – hepatitis B patients vs. group II: NAFLD – hepatitis B patients). Data demographic and clinical examination were collected. Significant liver fibrosis was defined as stage liver fibrosis above 7 kPa (≥ F2). Logistic regression was used to identify NAFLD as risk factor for significant fibrosis. Variables were expressed as prevalence odd ratio (POR) with 95% CI. P values <0.05 were considered statistically significant. Results. Among 130 hepatitis B patients, 45 patients (34.6%) were diagnosed with NAFLD. Of 45 patients in group II, 36 patients (80%) had significant liver fibrosis. It was observed that a higher percentage of patients in group II were HBeAg negative compared to those in group I (66.7% vs. 35.9%; p=0.038). Furthermore, group II also displayed higher levels of liver stiffness compared to group I (12.22 (8.6 kPa) vs. 8.57 (7.8 kPa); p 0.016). In multivariate analysis, NAFLD was significantly associated with significant liver fibrosis (POR: 5.87; CI95%: 2.48 – 13.86; p < 0.001) after adjusted with HBeAg status. Conclusion. NAFLD associated with the higher risk of liver fibrosis in patients with hepatitis B. Modification of lifestyle and potential therapeutic intervention may help in reducing the progression of liver fibrosis.
Profilaksis vs. Terapi Preemtif Penyakit Cytomegalovirus (CMV) pada Pasien Transplantasi Ginjal Risiko Tinggi: Suatu Laporan Kasus Berbasis Bukti
Authors:   Universitas Indonesia, Marbun Maruhum Bonar
Published: October 2023

Kidney transplant recipients require the use of immunosuppressive agents to prevent multiple organ rejection. Administration of immunosuppressive agents triggers an increased risk of impaired immunity and microbial infections, one of which is cytomegalovirus (CMV). Prevention of cytomegalovirus infection can be given as a prophylaxis or preemptive therapy. However, the efficacy of choosing prophylaxis or preemptive therapy is still under debate, thus we conducted this study to identify current approach in preventing CMV disease in clinical practice. A literature search was carried out using the PubMed, Cochrane Library, Embase and Scopus databases with the keywords “high risk kidney transplant”, “prophylaxis”, “preemptive” and “CMV infection disease”. Inclusion criteria were only studies in adult kidney transplant patients as a population. , prophylaxis as intervention, preemptive therapy as comparison, and cytomegalovirus infection as outcome. The exclusion criteria of this study were the study articles that were not in Bahasa Indonesia or English, case reports and studies with subjects <18 years old. Critical review using Oxford Center for Evidence Based Medicine (CEBM) Critical Appraisal Tools for Prognostic Study And Systematic Review. The total number of articles identified based on the keywords used is 115 articles. Eliminating duplication with EndNote resulted in 92 articles. Furthermore, exclusion was carried out based on title and abstract so that 29 articles were filtered for which the full text was available. Of these, 23 articles did not have appropriate research questions, 3 studies did not have appropriate patient populations, and 3 articles with types that did not meet the inclusion criteria of this study. As a result, there were 4 articles that can be used in this report. Based on those four articles, it can be concluded that prophylaxis is more effective in preventing CMV disease but had more side effects, when compared to preemptive therapy. However, there was no difference in long term outcome between kidney transplant patients with CMV prophylactic or preemptive therapy.
Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity
Authors: Sun Xiaomei , Ye Yuxin , Sakurai Naofumi , Wang Hang , Kato Koji , Yu Jian , Yuasa Keizo , Tsuji Akihiko , Yao Min
Published: October 2023

The defensive-offensive associations between algae and herbivores determine marine ecology. Brown algae utilize phlorotannin as their chemical defense against the predator
Aplysia kurodai
, which uses β-glucosidase (
aku
BGL) to digest the laminarin in algae to glucose. Moreover,
A. kurodai
employs
Eisenia
hydrolysis-enhancing protein (EHEP) as an offense to protect
aku
BGL activity from phlorotannin inhibition by precipitating phlorotannin. To underpin the molecular mechanism of this digestive-defensive-offensive system, we determined the structures of apo and tannic-acid (TNA, a phlorotannin-analog) bound form of EHEP, as well as apo
aku
BGL. EHEP consisted of three peritrophin-A domains formed in a triangle and bound TNA in the center without significant conformational changes. Structural comparison between EHEP and EHEP–TNA led us to find that EHEP can be resolubilized from phlorotannin-precipitation at an alkaline pH, which reflects a requirement in the digestive tract.
aku
BGL contained two GH1 domains, only one of which conserved the active site. Combining docking analysis, we propose the mechanisms by which phlorotannin inhibits
aku
BGL by occupying the substrate-binding pocket, and EHEP protects
aku
BGL against the inhibition by binding with phlorotannin to free the
aku
BGL pocket.
ATUM-Tomo: A multi-scale approach to cellular ultrastructure by combined volume scanning electron microscopy and electron tomography
Authors: Kislinger Georg , Fabig Gunar , Wehn Antonia , Rodriguez Lucia , Jiang Hanyi , Niemann Cornelia , Klymchenko Andrey S. , Plesnila Nikolaus , Misgeld Thomas , Müller-Reichert Thomas , Khalin Igor , Schifferer Martina
Published: October 2023

Like other volume electron microscopy approaches, Automated Tape Collecting Ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning electron microscopy (SEM). However, ATUM is unique by enabling hierarchical imaging and thus efficient screening for target structures as needed e.g., for correlated light and electron microscopy. However, SEM of sections on tape can only access the section surface, thereby limiting the axial resolution to the typical size of cellular vesicles, an order of magnitude lower than the acquired xy resolution. In contrast, serial-section electron tomography (ET), a transmission electron microscopy-based approach, yields isotropic voxels at full EM resolution, but requires deposition of sections on electron-permeant thin and fragile monolayer films – thus making screening of large section libraries difficult and prone to section loss. To combine the strength of both approaches, we developed ‘ATUM-Tomo’, a hybrid method, where sections are first reversibly attached to plastic tape via a dissolvable coating, and after screening detached and transferred to the ET-compatible thin films. Thus, ATUM-SEM of serial semi-thick sections and consecutive ET of one selected section combines SEM’s fast target recognition and coarse rendering capability with ET’s high-resolution volume visualizations – thus enabling multi-scale interrogation of cellular ultrastructure. As a proof-of-principle, we applied correlative ATUM-Tomo to study ultrastructural features of blood brain barrier (BBB) leakiness around microthrombi in a mouse model of traumatic brain injury. Microthrombi and associated sites of BBB leakiness were identified by confocal imaging of injected fluorescent and electron-dense nanoparticles, then relocalized by ATUM-SEM, and finally interrogated by correlated ATUM-Tomo, a workflow which created a seamless zoom-in on structural BBB pathology from the micro- to the nanometer scale. Overall, our new ATUM-Tomo approach will substantially advance ultrastructural analysis of biological phenomena that require cell- and tissue-level contextualization of the finest subcellular textures.
CTCN: a novel credit card fraud detection method based on Conditional Tabular Generative Adversarial Networks and Temporal Convolutional Network
Authors: Zhao Xiaoyan , Guan Shaopeng
Published: October 2023

Credit card fraud can lead to significant financial losses for both individuals and financial institutions. In this article, we propose a novel method called CTCN, which uses Conditional Tabular Generative Adversarial Networks (CTGAN) and temporal convolutional network (TCN) for credit card fraud detection. Our approach includes an oversampling algorithm that uses CTGAN to balance the dataset, and Neighborhood Cleaning Rule (NCL) to filter out majority class samples that overlap with the minority class. We generate synthetic minority class samples that conform to the original data distribution, resulting in a balanced dataset. We then employ TCN to analyze transaction sequences and capture long-term dependencies between data, revealing potential relationships between transaction sequences, thus achieving accurate credit card fraud detection. Experiments on three public datasets demonstrate that our proposed method outperforms current machine learning and deep learning methods, as measured by recall, F1-Score, and AUC-ROC.
Teaching/Learning French Through Web 2.0 Technology (Example of Gazi and Kırıkkale Universities)
Authors: CEYLAN PHİRİ Sakine , ÖZÇELİK Nurten
Published: October 2023

Bu çalışmada, Web 2.0 teknolojisinin Fransızca öğretimi ve öğrenimine katkısı yabancı dil öğretimi/öğrenimi kapsamında incelenmiştir. Nitel araştırma deseninde ve tarama modelinde yapılandırdığımız çalışmamızın amacı üniversite öğrencilerinin
Web 2.0 teknolojilerini kullanma durumları, dil becerilerini geliştirme düzeyleri ve dil öğrenimine bağlı olarak bu teknolojiden faydalanma durumlarını ortaya çıkarmak ve bu değişkenlerin yaş, cinsiyet, bölüm ve sınıf açısından
değişiklik gösterip göstermediğini incelemektir. Bu değişkenleri ölçmek adına 32 maddeden oluşan çevrimiçi bir anket çalışmasına yer verilmiştir. Anket Türkiye’deki üniversitelerden Gazi Üniversitesi, Gazi Eğitim Fakültesi Yabancı
Diller Eğitimi Bölümü Fransız Dili Eğitimi Anabilim Dalı ve Kırıkkale Üniversitesi Fen-Edebiyat, Fakültesi Mütercim Tercümanlık Bölümü Hazırlık, 1, 2, 3 ve 4. sınıf öğrencilerinden toplam 253 öğrenciyi kapsamıştır. Sonuç olarak,
Web 2.0 tabanlı sosyal paylaşım sitelerinden Fransızca öğrenimi için yararlanıldığı ve öğrencilerin özellikle Fransızca’nın dinleme, sözcük ve dilbilgisi becerilerini geliştirmeye çalıştıkları görülmüştür. Ayrıca, bu teknolojiyi
kullanım çekincelerinin Fransızca öğrenim tabanlı uygulama, site ya da araçlarını bilmediklerinden kaynaklandığı sonucuna varılmıştır. Yaş, cinsiyet ve bölüm değişkenleri incelendiğinde belirgin farklılıklar olmadığı ortaya çıkmıştır.
Ancak sınıf değişkenine bakıldığında 4. sınıflar ve hazırlık grupları arasında farklılıklar olduğu görülmüştür. 4. sınıf öğrencilerinin hazırlık gruplarına göre Fransızca öğreniminde Web teknolojilerini kullanmada daha özerk olduğu
gözlemlenmiştir. Web 2.0 teknolojilerini kullanım bağlamında 4. sınıf öğrencilerinin teknik ve bilgi edinme özerkliğini diğer sınıflara göre daha önce edindiği sonucuna varılmıştır.
Opinions of Parents with Children in Early Childhood Period Regarding Playgrounds
Authors: TEKİN Neslihan
Published: October 2023

Bu araştırma erken çocukluk döneminde çocuğu olan ebeveynlerin çocuk parklarına ilişkin görüşlerini incelemek amacıyla yapılmıştır. Araştırma nitel araştırma yöntemlerinden biri olan olgu bilim çalışması ile desenlenmiştir. Çalışma
grubu için kolay ulaşılabilir durum örnekleme yöntemi kullanılmıştır. Etik kurulu onayı alındıktan sonra görüşmeler 17 anne ve 8 baba olmak üzere toplam 25 ebeveyn ile gerçekleştirilmiştir. Veriler yarı yapılandırılmış görüşme
formu kullanılarak toplanmıştır. Görüşme formu araştırmacı tarafından alan yazın incelemesi yapılarak hazırlanmıştır. Hazırlanan form alan uzman görüşüne gönderilmiş ve uzmanların görüşleri doğrultusunda tekrar düzenlenmiştir.
Formu test etmek amacıyla iki anne baba ile ön görüşme yapıldıktan sonra uygulamaya çıkılmıştır. Görüşme öncesinde ailelere çalışmanın bilimsel bir araştırma olduğu ve kişisel verilerin gizli tutulacağına dair bilgiler verilmiştir.
Görüşmeler her bir anne baba için 40 dakika sürmüştür. Görüşmelerde anne ve babalar ses kaydı istemedikleri için ses kayıt cihazı kullanılmamıştır. Elde edilen veriler içerik analizi ve betimsel analiz tekniği kullanılarak düzenlenmiştir.
Araştırma sonucunda anne ve babaların çocuk parklarının çocuklarının gelişimlerine, bilişsel, duyuşsal, devinişsel alanlarda önemli katkılarının olduğunu belirtmişlerdir. Ebeveynler oyun parklarında çocuklarının güvenliklerinin
sağlanması ve oyun parklarında çocuklar için farklı oyun alanlarının olması gerektiğini ifade etmişlerdir. Anne ve babalar parkta çocuklarının çoğunlukla parklardaki oyun araçlarıyla ve arkadaşlarıyla kovalamaca vb. hareketli oyunlar,
evcilik gibi oyunlar oynadıklarını belirtmişlerdir. Anne ve babaların büyük çoğunluğu parklarda çocuklarına eşlik ettikleri ve eşlik eden kişinin büyük çoğunlukla annelerin olduğu tespit edilmiştir
Cardiac Hypertrophy in an Infant of a Diabetic Mother: A Case of Reversible Cardiomyopathy
Authors: Laxman Basany , Gandrakota Naga Priyanka , Batthula Vinay , Gudipati Rajesh Babu
Published: October 2023

Diabetes Mellitus (DM) is a chronic metabolic disorder characterised by insulin deficiency or resistance and/or β-cell defects. High Body Mass Index (BMI) at conception, undiagnosed pregestational diabetes, and poor glycaemic control significantly affect the foetal heart, foetoplacental circulation and foetal growth. Myocardial hypertrophy and cardiac defects are more prevalent in Infants of Diabetic Mothers (IDMs). Cardiac Hypertrophy (CH) is characterised by a significant thickening of the interventricular septum, reduction in the size of the ventricular cavity, systolic and diastolic dysfunction and subaortic stenosis. A term neonate born to a mother with pregestational insulin-dependent Type I Diabetes Mellitus (T1DM) developed respiratory distress soon after birth, and Echocardiography (ECHO) showed Asymmetric Septal Hypertrophy (ASH) and Left Ventricular Outflow Tract (LVOT) obstruction. The baby responded well to oral propranolol, which was continued for four weeks, resulting in the resolution of CH at four months of age on follow-up. The present case underscores the importance of ECHO, even in infants born to mothers with good glycaemic control.
Efficacy and Safety of Naproxen Gel in Musculoskeletal Pain Management: A Prospective Cohort Study
Authors: Kanthi Kiran G , Baghel Paritosh , Shah Nadir , Shendage Sudhir , Basu Anindya , Bhushan Bharat , Dutt Indranil , Batra Deepak , Kishore NL
Published: October 2023

Introduction: Naproxen is effective for various musculoskeletal conditions and has a longer half-life, making it a favourable choice for sustained relief. Additionally, there is a potential unmet need for guidelines on the usage of topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Asia-Pacific region. A study on naproxen 10% gel aims to address this need and increase awareness of its therapeutic potential in the region. Aim: To assess the efficacy and safety of naproxen 10% gel in relieving pain associated with lower back, knee, cervical, synovitis, bursitis, muscle sprain, and tendinitis. Materials and Methods: This prospective, cohort, observational, open-label, single-arm, multicentric study was conducted at 458 centres in India, including Ahmedabad, Bengaluru, Chandigarh, Chennai, Delhi, Guwahati, Hyderabad, Indore, Jaipur, Kolkata, Lucknow, Meerut, Mumbai, Patna, and Pune, between February 2023 and May 2023. The data was collected from outpatient settings/clinics of orthopaedicians and clinicians who have been prescribing topical naproxen 10% gel to their patients. The study included patients aged 18 to 60 years of either sex who were suffering from back pain, muscle pain, sprains, frozen shoulder, arthritis, acute low back ache (non-specific), or pain. The data was captured during the scheduled follow-up visits planned by the treating clinician, with data recorded at 3, 5, 10, and 15 days. At the baseline visit, demographic details (age, sex, weight, height, body mass index, and symptoms), Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain subscale score, pain intensity on movement score, Visual Analogue Scale (VAS), and overall pain score were obtained. Results: Out of 10,587 patients, 10,265 completed the present study. The majority of patients had lower back pain (n=3386, 32.99%) and knee pain (n=3184, 31.02%). The average pain intensity on movement score of patients with bursitis significantly decreased from the baseline to 15 days {mean change {95% Confidence Interval (CI)}: 6.04 (5.89, 6.20); p<0.001}. Post-naproxen treatment, the average pain intensity, WOMAC pain score, VAS, and overall pain score significantly decreased from baseline to day 15 in patients with knee pain and lower back pain. A significant improvement in WOMAC, WOMAC pain (5.42 vs 17.98), WOMAC stiffness (1.49 vs 5.75), and WOMAC physical function score (18.93 vs 56.21) at day 15 was observed in patients with a muscle sprain. Adverse Events (AE) were reported in 173 (1.69%) patients overall, with dryness (n=125) being the most common, followed by erythema (n=20) and pruritus (n=17). Conclusion: Naproxen 10% gel is an effective topical treatment for lower back pain, knee pain, cervical pain, synovitis, bursitis, muscle sprain, and tendinitis. It could prove helpful in patients where the side-effects of oral NSAIDs are to be avoided.
Positive Relationships between Service Performance and Social Media Use in Internet Retailing
Authors: Cho Yun Kyung , Sutton Cynthia L , Taskin Nazim
Published: October 2023

The purpose of this research is to investigate whether differences in Internet retailer service performance influence the use of social media. Information economic theory is used to hypothesize a positive relationship between performance and social media use. To test the relationship, 516 Internet retailers’ websites were investigated, and their service performance was analyzed based on online customer reviews. Exploratory factor analysis transformed the customer review data into refined measurements. The logistic regression model validated the positive relationship between service performance and social media use. Internet retailers who use social media show higher service performance. However, the significant effect is limited to online service performance. Offline service performance (i.e., order fulfillment service performance) was not significantly associated with social media use. This study considers information symmetry as a critical factor in social media use, which differs from previous studies based on traditional technology acceptance frameworks.
Understanding the Relationship between Polycystic Ovarian Syndrome (PCOS) and Dyslipidemia
Authors: Amadi Chikadibia Fyneface , Okolonkwo Benjamin Nnamdi , George-Oparati Melody Igochiyerum , Odiabara Kingsley Kalawari
Published: October 2023

Polycystic ovarian syndrome (PCOS) is a heterogenous disorder characterized by signs and symptom of androgen excess and ovarian dysfunction in the absence of other diagnosis, with a prevalence of ~6%-~20%. The aetiology of PCOS can either be unknown (primary) or originating from identifiable causes (secondary) like obesity, idiopathic hirsutism, epilepsy, androgen-secreting tumors etc. Weight gain especially around the stomach, missed, irregular or light menstruations, hyperandrogenism, infertility can serve as indicators for PCOS. This review is aimed at examining the relationship that exists between PCOS and dyslipidemia. With a prevalence report of about 70%, dyslipidemia, is related to PCOS, and its causes are multifactorial with many cases being undiagnosed due to different diagnostics criteria for PCOS. Studies revealed that women with PCOS showed increased levels of LDL-cholesterol, VLD Lipoprotein, ApoC-I, lipoprotein (a), decreased levels of HDL-cholesterol and ApoA-I while ApoB. Psychophysiology in dyslipidemia in PCOS include: obesity, hyperandrogenism. Insulin resistance. Diagnostic measures include: complete lipid profile test, pelvic ultrasound and transvaginal scan, hormone tests, glucose and insulin tolerance test, etc. There is no known cure of PCOS reported yet but there are different options on management which include lifestyle change, use of statin drugs if lifestyle modifications do not work, use of androgen inhibiting drugs and metformin might help. It is important and more advisable for the age range for PCOS testing to be reduced to accommodate females just entering puberty.
A Thailand-based Comparative Study of Government and Private School Teachers’ Perceptions of School Heads’ Level of Instructional Leadership
Authors: Nolasco Rhia Monica G. , Fabella Frederick Edward T.
Published: October 2023

This study investigated the differences in perception of Filipino teachers employed in government and private school teachers based in Thailand of the instructional leadership of their respective school heads. 65 Filipino teachers volunteered to be the respondents of this study. Thirty-two (32) were teachers in government schools while thirty-three (33) were private school teachers. The Instructional Leadership Questionnaire (ILQ), which measures the respondent’s perception of a school leader’s 7 domains of instructional leadership, namely: Instructional Resource Provider (7 items), Maintain Visible Presence (6 items), Professional Development (7 items), Maximize Instructional Time (6 items), Monitoring Students’ Progress (4 items), Feedback on Teaching Learning  (5 items) and Curriculum Implementation (5 items) was administered on the respondents. In terms of instructional resource provider and curriculum implementation, similar scores were obtained by government and private school teachers. However, the private school teachers had higher ratings for their respective school leaders in the domains of Maintain Visible Presence, Professional Development, Maximize Instructional Time, Monitoring Students’ Progress and Feedback on Teaching Learning. Statistically significant differences were established in the domains Professional Development and Monitoring Students’ Progress. In both these domains, the means of the private school teachers were higher than those of the government teachers.
Properties and Convergence Analysis of Orthogonal Polynomials, Reproducing Kernels, and Bases in Hilbert Spaces Associated with Norm-Attainable Operators
Authors: Evans Mogoi N.
Published: October 2023

This research paper delves into the properties and convergence behaviors of various sequences of orthogonal polynomials, reproducing kernels, and bases within Hilbert spaces governed by norm-attainable operators. Through rigorous analysis, the study establishes the completeness of the sequences of monic orthogonal polynomials and orthonormal polynomials, highlighting their comprehensive representation and approximation capabilities in the Hilbert space. The paper also demonstrates the completeness and density attributes of the sequence of normalized reproducing kernels, showcasing its effective role in capturing the intrinsic structure of the space. Additionally, the research investigates the uniform convergence of these sequences, revealing their convergence to essential operators within the Hilbert space. Ultimately, these results contribute to both theoretical understanding and practical applications in various fields by providing insights into function approximation and representation within this mathematical framework.
Phytochemical Screening, Evaluation and Comparative Study of the Antioxidant Activities of Leaves and Stem Bark Extracts from Anogeissus leiocarpus: A Plant Used in Traditional Medicine in Northern Ivory Coast
Authors: Hyacinthe Ouattara Logopho , Dezay Yoro Thierry , Souleymane Bamba , Roselin Mouho Guéi Didier , N’guessan Patrick Audrey , Koffi Yao Jean landry , Yéo Sigata , Zon Doumadé , Kablan Ahmont Landry Claude
Published: October 2023

Anogeissus leiocarpus is a medicinal plant from Ivory Coast. It would be traditionally used to treat several pathologies. The aim of this study was to confirm or refute the use of both leaves and stem bark in the prevention or treatment of diseases linked to oxidative stress. Phytochemical sorting in these two organs of Anogeissus leiocarpus showed the presence of flavonoids, coumarins, tannins, phenolic acids, sterols and terpenes. The radical DPPH scavenging activity was carried out qualitatively and quantitatively by thin layer chromatographic (TLC) and spectroscopic methods, respectively. Quantitative analysis by spectrophotometry showed that the antioxidant power of the stem bark is slightly higher than leaves. These organs could therefore be used as good antioxidants in the prevention and treatment of diseases linked to oxidative stress. However, works on safeness should contribute to the valorisation of these materials for giving in use as herbal drug accessible to all social classes.
Adaptation Strategies for Enhancing Sustainable Smallholder Dairy Cattle Productivity under the Regime of Climate Change in Bungoma County, Kenya
Authors: Nalianya Gregory
Published: October 2023

The study evaluated adaptation strategies for enhancing sustainable dairy cattle herd productivity under the present of climate change scenario. The study was conducted in three selected Sub Counties of Bungoma County that is Tongaren, Mt. Elgon, and Kimilili, Sub Counties with estimated total population of 900 smallholders. A cross-sectional, correction and evaluation research designs was used to provide an accurate portrayal of the characteristics of the respondents. A sample size of 415 respondents was used and served with questionnaires to solicit their responses. A review of empirical reports, interviews of key stakeholders, NGOs, professionals in the Kenya Metrological Department as well as ministry of agriculture was used to compliment data gathered through questionnaires. Quantitative data was analyzed using Microsoft Excel and SPSS software. From the results farmers use the following adaptation strategies as a matter of priority of strategies to enhance productivity; - growing of early maturing and drought resistant crops varieties. Making silage and preserving of farm residues for dry spells. Farmers are collaborating with veterinary officers during breeding so as to improve on the quality of cows kept. This study recommends to all stakeholder to formulate policies to empower farmers to effectively adapt to climate change and variability for enhancing smallholder dairy cattle herd productivity in the county.
Assessment of Water and Stream Sediment Pollution Related to Artisanal Mining in Alga, Burkina Faso, West Africa
Authors: Kagambega N. , Ouedraogo M. , Sam U.
Published: October 2023

Burkina Faso, like several other countries in the Sahelo-Sahelian strip, has seen a significant change in its mining sector in recent years through the development of the industrial and artisanal mining sub-sectors. The purpose of this study is to assess the level of pollution of water and stream sediments in the study area. A total of twenty-eight samples were taken, including three surface water samples, nine groundwater samples, ten stream sediment samples and six mine tailings samples. The analysis of the physico-chemical parameters and the metal content (cadmium, chrome, copper, mercury, nickel, lead, zinc and arsenic) of the water show that the values meet the drinking water standards in force in Burkina Faso. However, the various indices calculated, namely the geo-accumulation index (Igeo), the contamination factor (CF) and the enrichment factor (EF) show that the total metal contents of stream sediments are not d lithogenic (natural) origin but attributable to artisanal mining in the village of Alga. They highlight metal pollution with high levels of arsenic and cadmium and extremely high levels of mercury.
A Case Report on Recurrent Episodes of Dyselectrolytemia Diagnosed as Gitleman Syndrome
Authors: Priyadharshini V.  , Ganesh Deepika , Rajmahizhan T.
Published: October 2023

Background: Gitleman syndrome (GS) is also known as familial hypokalaemia-hypomagnesemia, which is a rare genetic disorder. It is an autosomal recessive disease that is characterized by hypokalaemia, hypomagnesemia, metabolic alkalosis, hypocalciuric hypercalcemia and hyperaldosteronism.

Case Report: 70-year-old female patient who was diagnosed with Gitelman syndrome with the symptoms of loss of appetite, muscle weakness, and abdominal pain. Electrolyte levels were low. After inconclusive evidence from laboratory investigation, genetic testing was performed. The detection of the SLC12A3 gene mutation encoding thiazide diuretic sensitive sodium chloride cotransporter located in DCT of kidney, confirmed the diagnosis of GS with c.1331delA variant. No pathological variant of CLCNKB for Bartter syndrome has been found. The patient was treated with parenteral normal saline, potassium chloride, Arachitol, spironolactone, metoclopramide, and MgD3 (magnesium glycinate and vitamin D3), the symptoms was significantly relieved. After discharge the intravenous medicines were shifted to oral and followed up with serum electrolyte levels in our institute.
Analysis of Genetic variability and Character association in Fennel (Foeniculum vulgare Mill.) Germplasm
Authors: Deshwal Narendra , Singh Dhirendra , Poonia Mukesh Kumar
Published: October 2023

Two hundred sixteen germplasms with six check varieties of fennel (Foeniculum vulgare Mill.) were evaluated in augmented randomized complete block design in four blocks during Rabi 2016-17 at Research Farm, SKN college of agriculture, Jobner to determine nature of variability, character association. Analysis of variance revealed significant differences among the genotypes and checks for all the characters except days to 50 per cent flowering in genotypes. The highest PCV and GCV expressed as percentage was observed for seed yield per plant followed by seeds per umbel, umbels per plant, branches per plant, umbellets per umbel, test weight, plant height, days to maturity and days to 50 per cent flowering. The high estimates of heritability and genetic advance were found for seed yield per plant, seeds per umbel, umbels per plant and branches per plant whereas it was low for days to 50 per cent flowering and days to maturity. Correlation studies revealed that seed yield per plant was significantly and positively correlated with test weight, seeds per umbel, umbellets per umbel and umbels per umbel. Out of 216 genotypes, 14 genotypes were better than the best check variety RF-125 on the basis of seed yield per plant. Some of the promising genotypes identified on the basis of seed yield per plant were UF-4, UF-16, UF-20, UF-23, UF-55, UF-61, UF-79, UF-88, UF-145, UF-149, UF-151, UF-168, UF-172 and UF-189. These superior genotypes can be used as donors in breeding programme.
Ongoing Challenges in the Diagnosis of Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
Authors: Lipps Patrick , Ayroza Galvão Ribeiro Gomes Ana Beatriz , Kulsvehagen Laila , Mutke Matthias Anthony , Kuhle Jens , Papadopoulou Athina , Pröbstel Anne-Katrin
Published: October 2023

This cross-sectional study examines whether proposed myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) diagnostic criteria can exclude other diseases, such as multiple sclerosis, and rely on results of cell-based assays.
Robust Molecular Anodes for Electrocatalytic Water Oxidation Based on Electropolymerized Molecular Cu Complexes
Authors: Amthor Sebastian , Ranu Koushik , Bellido Carlos G. , Salomón Fernando F. , Piccioni Alberto , Mazzaro Raffaello , Boscherini Federico , Pasquini Luca , Gil‐Sepulcre Marcos , Llobet Antoni
Published: October 2023

A multistep synthesis of a new tetra‐amidate macrocyclic ligand functionalized with alkyl‐thiophene moieties, 15,15‐bis(6‐(thiophen‐3‐yl)hexyl)‐8,13‐dihydro‐5H‐dibenzo[b,h][1,4,7,10]tetraazacyclotridecine‐6,7,14,16(15H,17H)‐tetraone, H4L, is reported. The reaction of the deprotonated ligand, L4−, and Cu(II) generates the complex [LCu]2−, that can be further oxidized to Cu(III) with iodine to generate [LCu]−. The H4L ligand and their Cu complexes have been thoroughly characterized by analytic and spectroscopic techniques (including X‐ray Absorption Spectroscopy, XAS). Under oxidative conditions, the thiophene group of [LCu]2− complex polymerizes on the surface of graphitic electrodes (glassy carbon disks (GC), glassy carbon plates (GCp), carbon nanotubes (CNT), or graphite felts (GF)) generating highly stable thin films. With CNTs deposited on a GC by drop casting, hybrid molecular materials labeled as GC/CNT@p‐[LCu]2− are obtained. The latter are characterized by electrochemical techniques that show their capacity to electrocatalytically oxidize water to dioxygen at neutral pH. These new molecular anodes achieve current densities in the range of 0.4 mA cm−2 at 1.30 V versus NHE with an onset overpotential at ≈250 mV. Bulk electrolysis experiments show an excellent stability achieving TONs in the range of 7600 during 24 h with no apparent loss of catalytic activity and maintaining the molecular catalyst integrity, as evidenced by electrochemical techniques and XAS spectroscopy.