bluuebunny/crossref_metadata_2025 huggingface dataset:
Intravenous Thrombolysis for Acute Mild Ischemic Stroke Patients: Higher ABCD2 Score Associated with Better Outcome
Authors: Li Runnan , Han Chunyan , Cai Xiuying , Kong Yan , Zhang Lulu , Lu Zhengyang , Liu Xueyun , Fang Qi , Zhu Juehua
Published: June 2019

Background: Up to 30% of patients with mild ischemic stroke suffer neurologic deterioration. However, optimal medical approaches of such patients remain controversial given the efficacy and safety of intravenous thrombolysis (IVT). The purpose of this study was to evaluate whether patients with acute mild stroke stratified with ABCD2 score (the risk of stroke on basis of age, blood pressure, clinical features, duration of symptoms, and presence of diabetes mellitus) could benefit from IVT.
Methods: Among 3321 patients with a final diagnosis of acute ischemic stroke, we retrospectively included 224 patients identified with acute mild neurologic deficits (National Institution of Health Stroke Scale, NIHSS ≤5) treated with or without IVT. Odds ratios (OR) with their confidence intervals (CI) for outcomes between groups were assessed by using multivariable binary logistic regression analyses. And the heterogeneity of treatment effect magnitude for excellent outcome at 90d (modified Rankin Scale [mRS] 0-1) was estimated in different subgroups.
Results: A total of 224 cases were enrolled, 106 receiving IVT and 118 treated with secondary stroke prevention strategies alone. At 7d, 30 (28.3%) patients with IVT treatment versus 16 (13.6%) patients not receiving IVT achieved significant improvement (≥4-point NIHSS score decrease or complete resolution; OR, 2.448; 95%CI, 1.204-4.977; P=0.013). At 90d, excellent outcome was achieved in 83 (78.3%) patients treated with IVT versus 77 (65.35%) patients without IVT treatment (OR, 3.156; 95%CI, 1.526-6.528; P=0.002), especially in those with ABCD2 score ≥5 (OR, 2.768; 95%CI, 1.196-6.406; P=0.017) and with stroke subtype of large artery atherosclerosis (OR, 5.616; 95%CI, 1.080-29.210; P=0.040). Besides, 7(6.6%) IVT-treated patients versus 2 (1.7%) non-IVT-treated patients developed intracranial hemorrhage (ICH; P=0.359), among these only 1 (0.9%) was symptomatic ICH in IVT group.
Conclusions: For acute mild ischemic stroke patients, we reassured the safety and especially the efficacy of IVT at 7- and 90-days. Patients with 5 or more of ABCD2 score and stroke subtype of large artery atherosclerosis might benefit more from IVT.
Black holes, heavy states, phase shift and anomalous dimensions
Authors: Kulaxizi Manuela , Ng Gim Seng , Parnachev Andrei
Published: June 2019

We compute the phase shift of a highly energetic particle traveling
in the background of an asymptotically AdS black hole. In the dual CFT,
the phase shift is related to a four point function in the Regge limit.
The black hole mass is translated to the ratio between the conformal
dimension of a heavy operator and the central charge. This ratio serves
as a useful expansion parameter; its power measures the number of stress
tensors appearing in the intermediate channel. We compute the leading
term in the phase shift in a holographic CFT of arbitrary dimensionality
using Conformal Regge Theory and observe complete agreement with the
gravity result. In a two-dimensional CFT with a large central charge the
heavy-heavy-light-light Virasoro vacuum block reproduces the gravity
phase shift to all orders in the expansion parameter. We show that the
leading order phase shift is related to the anomalous dimensions of
certain double trace operators and verify this agreement using known
results for the latter. We also perform a separate gravity calculation
of these anomalous dimensions to second order in the expansion parameter
and compare with the phase shift expansion.
Development of Efficient Weed Management Practices for Drilled Paddy Production under Gujarat condition
Authors: Hajari R, V , MACHHAR R G , Mahida A. K. , HADIYA G D , MAHIDA A K
Published: June 2019

To study the weed management in drilled paddy an experiment was conducted at Agriculture Research Station, Anand Agricultural University, Derol Dist: panchmahal, Gujarat during kharif seasons of the years 2012-13, 2013-14 ,2014-15 and 2015 -16 . Ten treatments for weed management were studied in randomized block design with four replications. Results that all the growth and yield attributes except plant height and test weight were significantly influenced due to different weed control treatments. The grain and straw yield of drilled paddy were also altered significant due to weed control treatments. In general, T2 (two hand weeding at 20 and 40 DAS) recorded the highest yield among all. It was, however, at par with three other treatments which included pre and post emergence application of herbicides. Since, the application of Oxadiargyl @ 90 g/ha f/b Bisbyribac sodium @ 25 g/ha at 20 DAS is one among the dual application of herbicide, it can be recommended for drilled paddy in options of two hand weeding.
Projetos para envelhecer: etnografia das formas de sociabilidades e das trajetórias de vida de veteranos do remo
Authors: Vianna Luciano von der Goltz , Eckert (orientação) Cornelia
Published: June 2019

Partindo de um exercício etnográfico, com pesquisa de campo iniciada em 2007, esse artigo busca compreender as práticas de sociabilidade relacionadas às trajetórias de vida dos integrantes de um grupo de senhores, veteranos do Remo no Clube de Regatas Guaíba-Porto Alegre. A expressão de seus saberes e práticas são construídas na observação participante no processo ritual que denominam “café na ilha do Oliveira” (pequena ilha do Delta do Jacuí) realizado nas manhãs dos domingos. O uso da imagem fotográfica e fílmica foi um importante recurso e motivo para o encontro intersubjetivo pesquisador/informante. A forma de narrar as experiências dos tempos vividos converge com as trajetórias de vida dos integrantes do grupo de veteranos, o que tece referências de pertença de identidade geracional tratadas a partir do tema da memória coletiva. Estas trajetórias são referidas ao processo de vida urbana e ao sistema de sentidos da sociedade complexa nas tensões e conflitos em torno dos valores de individualização e de hierarquização. Palavras chave: Trajetórias de vida. Projeto. Envelhecimento.   Projects to aging: ethnography of forms of sociabilities and life trajectories of veterans of rowing   Abstract   Based on an ethnographic exercise, with field research started in 2007, this article seeks to understand the practices of sociability related to the life trajectories of members of a group of gentlemen, veterans of the Rowing Club Regatta Guaíba-Porto Alegre. The expression of their knowledge and practices are built on participant observation in the ritual process they call "coffee on the island of Oliveira" (small island in the Delta Jacuí) held on Sunday morning. The use of photographic and filmic image was an important resource and meeting ground for intersubjective researcher / informant. The way of narrating lived experiences of time coincides with the life trajectories of members of the veterans group, which weaves references generational identity of belonging treated as the theme of collective memory. These trajectories are referred to the process of urban life and the system of complex society in the sense of the tensions and conflicts around the values of individuation and hierarchy. Keywords: trajectories of life. Project. Aging.
Breves considerações sobre os territórios negros urbanos de Porto Alegre na pós-abolição
Authors: Bohrer Felipe Rodrigues
Published: June 2019

O presente texto tem por objetivo realizar questionamentos teóricos-metodológicos sobre a investigação dos Territórios Negros de Porto Alegre no período da pós-abolição. A preocupação reside em salientar a importância de situar a pesquisa na atuação dos sujeitos em diálogo com o contexto na qual estão inseridas. Para isso, será realizado primeiramente uma revisão crítica da historiografia local para justificar o primeiro intento (atuação do sujeito), e, no segundo momento, iremos discutir a necessidade de vinculação ao contexto para sua melhor compreensão. Palavras chave: Territórios Negros Urbanos. Identidade Étnica. Pós-Abolição.   Brief comments on the Territories Black Urban of Porto Alegre in post-abolition  Abstract   This paper aims to make theoretical and methodological questions about the investigation into the Black Urban Territories of Porto Alegre during the post-abolition. The concern is to emphasize the importance of situating the research in the performance of subjects in dialogue with the context in which they operate. This will be first performed a critical review of local history to justify the first attempt (the subject’s performance), and the second time, we will discuss the need for linking the context for better understanding. Keywords: Black Urban Territories. Ethnic Identify. Post-Abolition.
Do narrar o virtual e o real: experiência de uma tradução
Authors: Przybylski Mauren Pavão
Published: June 2019

Esta reflexão pretende ver a memória não só como seletiva, mas como um processo de negociação que visa conciliar a memória coletiva e a individual. Para tanto, se pretende considerar imagens e discursos elaborados por sujeitos que ocupam um determinado espaço, espaço esse em que acontecem conflitos, convívio social, trocas de informações, sensibilidades e práticas que conferem sentidos e significados. A internet é, por sua vez, ferramenta de constituição de um sujeito plural.  Ver e analisar a cidade não só por suas construções arquiteturais e por suas possíveis ocupações no espaço, mas, sobretudo, pela dimensão da existência, visto que ela é construída por homens e suas relações é o objetivo desta análise. Palavras chave: Memória. Internet. Espaço. Sujeito. Cidade.   Narrating the virtual and real: experience of a translation  Abstract   This reflection aims to see not only how selective memory, but as a negotiation process that seeks to reconcile individual and collective memory. To do so, whether to consider pictures and speeches written by individuals who occupy a given space, the space in which conflicts occur, social interaction, information exchange, sensibilities and practices that give sense and meaning. The Internet is, in turn, a tool for creating a plural subject .View and analyze the city not only for their architectural constructions and their possible occupations in space, but mainly by the dimension of existence, since it is built by men and their relationships is the goal of this analysis. Keywords: Memory. Internet. Space. Subject. City.
Influence of glazing type on energy efficiency of industrial buildings in the process of revitalization: A case study
Authors: Slavkovic Branko
Published: June 2019

This paper examines the possibilities of improving the energy performance of
an existing industrial building by application of the double skin fa?ade on
the revitalization of the building envelope in the climatic conditions of
the city Novi Pazar, Republic of Serbia. The aim is to examine the impact of
choosing the type of glazing, in the processes of revitalization, on the
energy needs of industrial buildings for heating and cooling, as well as the
contribution of the measures implemented to improve the energy performance
of the selected type and model of industrial building. The energy
performance of buildings was obtained using the software DesignBuilder and
EnergyPlus simulation platform, taking into account the parameters of
required internal temperature and climate data for the Republic of Serbia.
The comparative analysis of the results of energy simulation according to
the criterion of achieving greater energy savings and reduced carbon dioxide
emissions was performed. The methodological approach in this research
involves creating revitalization scenarios of industrial buildings with a
shed roof construction, selection of the specific building according to
whose properties by numerical simulation possibilities for energy
revitalization depletion were investigated and comparative analysis of the
obtained results was performed. The primary objective of this research is to
investigate the impact of choosing the type of glazing on the energy
performance of industrial buildings with a shed roof construction and to
determine the optimal approach to energy revitalization of existing
industrial buildings with the implementation of the double skin fa?ade under
the climatic conditions of the city Novi Pazar, Republic of Serbia. The
results of this paper indicate the negative characteristics of the kopilit
glass to solar gains, whose retention requires a large amount of heating
energy. While replacing of kopilit glass with a low-energy glass increases
the amount of energy required to cooling of the building. With this
research, through various revitalization scenarios, it is also indicated
that using a double skin fa?ade in the revitalization process of the
selected building, has a very similar impact on reducing CO2 emissions
regardless of the type of glazing choice.
Designing of children playgrounds from the aspect of used surfacing with a goal of children safety on the example of the City of Nis
Authors: Kekovic Aleksandar , Momcilovic-Petronijevic Ana , Curcic Aleksandra
Published: June 2019

When designing children playgrounds, one should take into consideration
numerous factors dictating safety of the children spending time on the
playground. Accessibility of individual parts of the playground, and quality
of the equipment, types of used materials in terms of durability,
non-toxicity, are only some of the factors which can have impact on the
safety. Also important are separation of children age-groups as well as of
the conflicting activities, visible labels and supervision. Also, the
spacing between the individual parts of equipment and types of used surfaces
should be considered. This paper analysis materials of the playground as an
element in designing, aimed at children safety. The research includes areas
for children play in the city of Nis, The analysis of children playgrounds
was performed on the most frequented parks in Nis - in Cair park, Sveti Sava
park and Fortress park. Also, there is an analysis of the children
playground in the retail park Stop Shop in Nis, which has been built most
recently. The goal of the paper is finding the actual condition of the
children playgrounds in Nis, from the mentioned aspect, as well as building
awareness about the importance of designing of safe children playgrounds.
An In Vitro Investigation of Anticaries Efficacy of Fluoride Varnishes
Authors: Dehailan L Al , Martinez-Mier EA , Eckert GJ , Lippert F
Published: June 2019

Most currently marketed fluoride varnishes (FVs) have not been evaluated for their effectiveness in preventing dental caries. The objective of this study was to investigate the anticaries efficacy, measured as fluoride release into artificial saliva (AS); change in surface microhardness of early enamel caries lesions; and enamel fluoride uptake (EFU) of 14 commercially available FVs and two control groups. Bovine enamel specimens (5×5 mm) were prepared and assigned to 18 groups (n=12). Early caries lesions were created in the specimens and characterized using Vickers microhardness (VHNlesion). FV was applied to each group of specimens. Immediately afterward, specimens were incubated in 4 mL of AS for 18 hours, which were collected and renewed every hour for the first six hours. AS samples were analyzed for fluoride using an ion-specific electrode. Specimens were then brushed for 20 seconds with toothpaste slurry and subjected to pH cycling consisting of a four-hour/day acid challenge and one-minute treatments with 1100 ppm F dentifrice for five days. Microhardness was measured following pH cycling (VHNpost). EFU was determined using microbiopsy. Acid resistance (eight-hour demin challenge) was performed after pH cycling, and microhardness was measured (VHNart) and compared with baseline values to test the FV impact after pH cycling. One-way analysis of variance was used for data analysis (α=0.05). FVs differed in their release characteristics (mean ± SD ranged from 14.97 ± 2.38 μg/mL to 0.50 ± 0.15 μg/mL), rehardening capability (mean ± SD ranged from 24.3 ± 15.1 to 11.7 ± 12.7), and ability to deliver fluoride to demineralized lesions (mean ± SD ranged from 3303 ± 789 μg/cm3 to 707 ± 238 μg/cm3). Statistically significant but weak linear associations were found between ΔVHN(post – lesion), EFU, and fluoride release (correlations 0.21-0.36). The results of this study demonstrated that differences in FV composition can affect their efficacy in in vitro conditions.
INITIAL PUBLIC OFFERING (IPO) OF CAPITAL MARKET AND CAPITAL MARKET COMPANIES IN INDONESIA
Authors: Hartana Hartana
Published: June 2019

From the aspect of Capital Market Law, the Initial Public Offering (IPO) conducted by PT. Dian Swastatika Sentosa Tbk (PT. DSS Tbk) is legitimate and has complied with all the provisions governing this matter. This can be seen in a series of stages of the IPO implementation carried out by PT. DSS Tbk. Likewise, if viewed from the legal aspects of Mineral and Coal Mining, it does not indicate any contradiction with the article governing Coal Mining if it is associated with the IPO process of PT. DSS Tbk. In conducting the IPO, PT. DSS Tbk does not experience significant obstacles. The only obstacles faced are small bureaucratic obstacles and policies can be overcome by the active role of Bapepam-LK. This shows that Bapepam-LK has acted as a dynamic supervisor.
Prática como componente curricular na licenciatura em Matemática de um instituto federal
Authors: BARBOSA LUCAS DIEGO ANTUNES , BIANCHINI BARBARA LUTAIF
Published: June 2019

ResumoO objetivo deste artigo é analisar como as atividades de Prática como Componente Curricular (PCC) estão organizadas nos Projetos Pedagógico de Curso da Licenciatura em Matemática de um Instituto Federal (IF). Esta investigação tem uma abordagem de pesquisa qualitativa, feita com base na análise do Projeto Pedagógico de Curso (PPC) da Licenciatura em Matemática de um Instituto Federal (IF) da região norte do Brasil. Para tanto, tomou-se Bardin como referencial metodológico. Além disso, adotamos como referencial teórico as contribuições de Cochran-Smith e Lytle, que apresentam concepções da formação de professores, o conhecimento para a prática, o conhecimento na prática e o conhecimento da prática. Percebemos que a PCC como conhecimento para a Prática foi organizada em disciplinas, o que na maioria das vezes dificulta o entendimento do que realmente é a PCC, já que fica ao critério de cada professor. Palavras-Chave: Formação Inicial; Prática como componente curricular; Licenciatura em Matemática.AbstractThe aim of this article is to analyze how the activities concernig Practice as a Curricular Component (PCC) are organized in the Pedagogical Projects of the Mathematics Licentiate Degree of a Federal Institute (FI). This research is based on a qualitative research approach, grounded on the analysis of the Pedagogical Course Project (PCP) of the Mathematics Licentiate Degree of a Federal Institute (FI) located in northern Brazil. Bardin was used as a methodological reference to this end. In addition, Cochran-Smith and Lytle's contributions, which present concepts on teacher training, knowledge for practice, knowledge in practice and knowledge of practice, are adopted as theoretical references. We perceive that the PCC as knowledge for Practice was organized in disciplines that, in most cases, makes it difficult to understand what the PCC really is, since this is up to each teacher.Keywords: Initial formation; Practice as a Curricular Component; Mathematics Licentiate Degree.
Discursos y subjetividades en la Argentina actual
Authors: Cebrelli Alejandra , Rosso Daniel , Martínez Fabiana , Restagno Alejandra
Published: June 2019

En esta sección recuperamos el panel “Discursos y subjetividades en la Argentina actual”, realizado en el XX Congreso de REDCOM, que contó con la presencia de Alejandra Cebrelli, Daniel Rosso y Fabiana Martínez.
redefinición de la información
Authors: Ackerman Sebastián Ernesto
Published: June 2019

A partir de la discusión por las retenciones móviles en 2008, el campo periodístico se dividió entre “Periodismo independiente” vs “Periodismo militante” como dos formas de ejercer la profesión. Por supuesto, esta dicotomía se planteó desde el sentido común dominante, que definía al periodismo como un “reflejo” de la realidad, por lo que la (supuesta) independencia era un atributo irrenunciable. Pero nosotros tomamos ese debate para intentar un nuevo acercamiento al estudio del periodismo gráfico. Lo que proponemos en este artículo es la redefinición de un concepto clave para estas investigaciones, como es el de información, como una forma particular de producción social de significaciones que borra sus propias huellas de producción. De esta manera, se abre un nuevo terreno para explorar las condiciones a partir de las cuales el sentido común se consolida en una sociedad.
Using Collision Cross Section Distributions to Assess the Distribution of Collision Cross Section Values
Authors: France Aidan , Migas Lukasz , Sinclair Eleanor , Bellina Bruno , Barran Perdita
Published: June 2019

In this study we explore the use of collision cross section distributions to allow comparability of IM-MS data for proteins on different instruments. We present measurements on seven standard proteins across three IM-MS configurations, namely an Agilent 6560 IM QToF, a Waters Synapt G2 possessing a TWIMS cell and a modified Synapt G2 possessing an RF confining linear field drift cell. Mobility measurements were taken using both He and N2 as the drift gases. To aid comparability across instruments and best assess the corresponding gas-phase conformational landscapes of the protein ‘standards’ we present the data in the form of averaged collision cross section distributions.
A governança no contexto da pesquisa em educação no Brasil
Authors: Santos Aline Veiga dos , Braga Isabela Cristina Marins , Guimarães-Iosif Ranilce Mascarenhas
Published: June 2019

O artigo analisa a emergência da “governança” na literatura internacional e nacional e seu uso nas pesquisas em educação no Brasil. Trata-se de um estudo analítico-descritivo das produções sobre a governança educacional cadastradas nas bases Scientific Electronic Library Online e Biblioteca Digital Brasileira de Teses e Dissertações no período de 2004 a 2015. Apesar de ser um campo de estudos incipiente, as pesquisas sobre o tema revelam-se fundamentais para a compreensão das mudanças ocorridas no papel do Estado na gestão de suas políticas a partir da década de 1990. Essa abordagem permite uma análise não linear das redes que compõem o complexo campo das políticas de educação.
A tese da primazia do reconhecimento sobre o conhecimento em Axel Honneth: contribuições para os processos educativos
Authors: Cenci Angelo Vitório
Published: June 2019

O artigo explora a tese honnethiana baseada no conceito de reconhecimento prévio da primazia do reconhecimento sobre o conhecimento. O objetivo é mostrar que tal tese, explicitada mediante os conceitos de reconhecimento prévio, gestos expressivos e atitude de implicação existencial, permite extrair importantes implicações educativas. Isso é indicado tanto no que tange à hipótese de uma continuidade entre os gestos expressivos de socialização infantil e as modalidades de aparição e de manifestação no espaço público mais amplo em que o sujeito agirá, quanto no que concerne às dimensões afetiva e cooperativa que estariam na base do reconhecimento humano e dos processos educativos.
Apresentação
Authors: Crusoé Nilma Margarida de Castro
Published: June 2019

Apresentação
STRATEGI PEMANFAATAN APLIKASI DESA APPS DALAM LITERASI INFORMASI PERTANIAN
Authors: Raya Alia Bihrajihant , Kriska Mesalia , Wastutiningsih Sri Peni , Cahyaningtyas Melisa Umi , Djitmau Adrian , Cahyani Galuh Friska
Published: June 2019

Information literacy is one part of community empowerment activities, especially in the information field. Information literacy is the ability to search, evaluate, and use information needed effectively. Basically information literacy is not a new ability or skill, but in the era of information disclosure, information literacy is a must-have skill requirement. The problems faced today, there is still an imbalance between the pace of information available and the level of agricultural information literacy at the farm level. The development of agricultural information through the internet has led to cyber extensions, information is available quickly and varied, but not all farmers are able to access and use it. The Faculty of Agriculture UGM has developed an application with the name DesaApps. DesaApps stands for Digital Extension Society for Agriculture Application which aims to be an application platform that provides agricultural counseling and develops a digital farming community. The existence of DesaApps can be useful for users of the application to provide information to one another, interact and transact in agriculture. The features in the DesaApps application consist of Frequently Asked Questions, Articles, Price Information, Farm Notes, Weather Information. Shop Information, Office Information, and Selling Items. Utilization of the features provided by Desa Apps provides an opportunity for farmers to obtain the information needed, as well as a means of improving the skills of managing information obtained. Therefore, the presence of Desa Apps empowers farmers to be independently informed. However, the performance of Desa Apps as one of the sources of information still needs to be improved. In order to be able to optimize the use of Village Apps, the utilization strategy is to improve application performance, promote and promote Village Apps, responsiveness of experts, and optimize the use of Desa Apps as a marketing place.
KOMUNIKASI PEMBANGUNAN MELALUI PROGRAM PEMBERDAYAAN SEBAGAI MATERI PEMBELAJARAN DI PESANTREN
Authors: Sulaiman Adhi Iman
Published: June 2019

Islamic boarding schools can act as religious education institutions and also become institutions of social and economic education in improving the welfare of pesantren, santri, alumni and their fellow communities. The research aims to design a model of development communication through the santri economic empowerment program in Islamic boarding school education. Using Participatory Learning and Action (PLA), the selection of informants purposively, consisting of boarding schools, religious teachers, santri and community leaders. Data collection through documentation analysis, direct observation, interviews, Focus Group Discussion (FGD) and Participatory Decision Making (PDM). Research location in Al-Muttaqin Islamic Boarding School, Beber Cirebon, West Java. Analysis of research data using interactive analysis through the stages of data reduction, data presentation and verification and conclusion. The results of the study show that pesantren can design a communication model for counseling and empowerment of santri economics through entrepreneurship and cooperative material in the education curriculum as a choice or additional lesson for santri along with practical and internship programs. Santri will have entrepreneurial skills, independence and welfare, create harmony with the community and anticipate the negative stigma of boarding schools that are exclusive, closed and radical.
Evaluación de dimetilsulfóxido y Aloe vera como potenciadores de la penetración para la aplicación cutánea de lidocaína
Authors: Bhinge Somnath Devidas , Bhutkar Mangesh Anil , Randive Dheeraj S , Nayakal Omprasad , Patil Prajakta
Published: June 2019

Objetivo: El objetivo del presente trabajo fue comparar y verificar la eficacia de Aloe vera (1 a 3%) con dimetilsulfoxido (1 a 3%) por su propiedad de mejora de la penetración para la administración tópica de lidocaína. Método: Carbopol 934 se usó como agente gelificante para la preparación de formulaciones de gel de lidocaína que contenían o no dimetilsulfoxido o Aloe vera (1%, 2% y 3%). Los geles se evaluaron por su aspecto físico, comportamiento reológico, contenido de fármaco, liberación de fármaco y estabilidad. Resultados: Se dedujo del resultado que la formulación del gel obtenido era adecuada en apariencia, homogeneidad y consistencia. Los perfiles de liberación de fármaco in vitro mostraron que conforme aumentaban el porcentaje de “Aloe vera” en las formulaciones, la tasa de liberación del fármaco se incrementaba sustancialmente. Se observó que la formulación F6 que contenía un 3% de Aloe vera como potenciador de la permeación exhibía un 79,18% de liberación de fármaco. De manera similar, para la formulación F3, que comprendía un 3% de DMSO como potenciador de la permeación, se encontró que la liberación del fármaco era del 84,52%. El uso de Aloe vera puede resultar beneficioso en comparación con los potenciadores de permeación sintéticos. Conclusión: Sobre la base de los resultados del estudio, se concluyó que el gel tópico de lidocaína preparado junto con Carbopol 934 mediante el uso de Aloe vera como un potenciador natural de la penetración a una concentración del 3%, se puede usar para mejorar la penetración de lidocaína en la piel.
Estudio sobre hábitos nocivos asociados al consumo televisivo en relación con las aficiones practicadas por alumnos de primaria durante su tiempo de ocio
Authors: Sánchez Escames Antonia , Baena Sánchez María José , Baena Sánchez Julia
Published: June 2019

Las actividades desarrolladas durante el tiempo de ocio infantil juegan un papel determinante en el desarrollo físico y mental del discente. Realizamos un estudio descriptivo transversal de observación prospectiva a 377 alumnos matriculados en los Centros de Educación Primaria con edades comprendidas entre los 8 y 13 años (M = 9.42 y la DT = 3.44). Un análisis de las respuestas recibidas a través del medio de contraste de hipótesis, sirve para poner de manifiesto que los alumnos aficionados a los videojuegos y a ver TV son los que más conductas nocivas asimilan, los que más trasnochan y los que, en mayor número de ocasiones, olvidan realizar sus tareas escolares; mientras que los aficionados a la lectura son los que consumen menos horas de TV. Por ello, proponemos talleres de lectura y fomentar el dibujo y las actividades de ocio al aire libre para disminuir el uso del televisor y videojuegos.
Невидимые механические включения в инъекционных лекарственных препаратах белковой природы
Authors: Новик Елена Самарьевна , Доренская Анна Викторовна , Борисова Наталья Александровна , Гунар Ольга Викторовна
Published: June 2019

Обзор посвящен описанию методологии определения содержания механических включений в инъекционных лекарственных препаратах (ЛП) белковой природы, в том числе внешних и внутренних частиц. Особое внимание уделено рассмотрению преимуществ и ограничений различных методов, применяемых для этих целей, каждый из которых дает возможность определить различные характеристики частиц. Применение методов, основанных на разных принципах измерения, позволяет лучше понять источники происхождения частиц (внешние, внутренние или собственные), изучить распределение частиц по размерам и другие характеристики, с помощью которых производится их дифференциация. Белковые агрегаты, присутствующие в ЛП, отличаются широким диапазоном распределения по размерам: от олигомеров до частиц, составляющих сотни микрон. Данные о свойствах частиц могут использоваться для оценки рисков, связанных с присутствием белковых агрегатов в ЛП, а также при изучении возможного механизма их формирования. Такая информация может быть полезна на стадиях разработки и производства ЛП для снижения содержания частиц.
Синтез, антиоксидантная и противогриппозная активность аминометансульфокислот
Authors: Хома Руслан Евгеньевич , Гельмбольдт Владимир Олегович , Эннан Алим Абдул Амидович , Гридина Татьяна Леонидовна , Федчук Алла Семеновна , Лозицкий Виктор Петрович , Ракипов Ильдар Марсович , Владыка Анатолий Степанович
Published: June 2019

Синтезированы аминометансульфокислота, а также ее N-метил- (II), N-(2-гидрокси)этил- (III), N-(трет-бутил)- (IV), N-бензил- (V) и 4-(N-фениламинометил)фенил- (VI) производные (V и VI ранее не описаны), которые охарактеризованы методами элементного анализа, ИК- и масс-спектроскопии. Оценена антиоксидантная активность I – VI in vitro, отмечены сравнительно слабые антиоксидантные свойства аминометансульфокислот. Показано, что соединения IV и V статистически значимо подавляют репродукцию вируса гриппа штаммов А/Гонконг/1/68 (H3N2) и А/PR/8/34(H1N1) на культуре ткани хорион-аллантоисных оболочек.
Поправочные коэффициенты в формулах для расчета содержания примесей: сущность, способы определения и их ограничения
Authors: Эпштейн Наум Аронович
Published: June 2019

Представлены формулы для расчета коэффициентов относительной чувствительности RRF (relative response factors) и поправочных коэффициентов F (correction factors) примесей, а также формулы, необходимые для понимания сущности коэффициентов RRF и F. Рассмотрены основные способы определения поправочных коэффициентов и их ограничения (условия, выполнение которых необходимо для корректного определения RRF и F). Эти ограничения не отражены в Европейской фармакопее и в Фармакопее США, но от их учета зависит правильность определения значений поправочных коэффициентов. Приведены примеры и даны рекомендации для надежного определения и правильного использования поправочных коэффициентов.
Internet distribution of luxury products
Authors: Kunda Ivana , Butorac Malnar Vlatka
Published: June 2019

Owing to its particular features, the
market of luxury goods is a point of

interest to lawyers as much as to other professions such as economists or
sociologists. These features play an important role in legal regulation of the
market. While the starting point is competition law, the assessment of
anticompetitive conduct under Article 101 of the TFEU cannot be complete
without resorting to intellectual property law policies and rules. With the
rise of the importance of internet sales, novel issues have been put before the
competition authorities and reviewing courts, such as legality of various types
of online restrictions in the selective distribution systems. Employing a
combined IP law

and competition law approach to these issues, this paper offers insights and
comments on EU case law, with primary focus on the recent CJEU judgment in
Coty. The intricacies of the interplay among different competition law rules
and exemptions is particularly evidenced in this case. However, limited by its
fact-pattern, the Coty judgment may serve as a clarification about the deluxe
competition law treatment only of certain online sale prohibitions within the
SDSs, while there will certainly be continuing discussions and national case
law developments on other internet related competition law restrictions
awaiting further elucidations by the CJEU.
PERANAN METODE DISKUSI MENGGUNAKAN MEDIA STIK ES KRIM DALAM MENINGKATKAN MOTIVASI, MINAT DAN HASIL BELAJAR MATEMATIKA KELAS II SEKOLAH DASAR NEGERI SRENGSENG SAWAH 12 PAGI JAKARTA
Authors: Suhaemi
Published: June 2019

Tujuan utama PTK ini adalah Upaya Meningkatkan Hasil Belajar Peserta Didik Kelas II Sekolah Dasar Negeri Srengseng Sawah 12 Pagi Kota Jakarta Selatan Pada Mata Pelajaran Matematika Tema Penjumlahan Dan Pengurangan Bilangan Sampai 500 Melalui Metode Diskusi Menggunakan Media Stik Es Krim. Penelitian Tindakan Kelas dilaksanakan di SDN Srengseng Sawah 12 Pagi Kecamatan Jagakarsa Kota Jakarta Selatandengan jumlah 31 orang peserta didik (18 laki – laki dan 13 perempuan) kelas II Pada pembelajaran prasiklus dengan menggunakan metode ceramah dan media buku cetak, papan tulis, peserta didik yang tuntas dalam belajar hanya 51%. Kemudian peneliti lanjutkan pada pembelajaran siklus I dengan menambahkan metode diskusi dan alat peraga jari tangan, peserta didik yang mencapai ketuntasan sebanyak 68%.Peneliti lanjutkan lagi pada pembelajaran siklus II, peneliti mencoba memperbaiki kekurang pada saat siklus 1 selain menggunakan metode diskusi juga menambahkan media stik es krim.Pada siklus 2 peserta didik yang tuntas dalam belajarnya sebanyak 97% peserta didik.Dengan demikian penerapan metode dan alat peraga stik es krim telah memberikan pengaruh yang sangat baik dengan meningkatkan hasil belajar dan motivasi peserta didik. Materi yang disampaikan dimengerti peserta didik, tanggung jawab peserta didik terhadap tugas tinggi, serta membantu peserta didik untuk terlibat aktif di dalam kelas
The Parasitism of Mathematics in Physics Learning
Authors: Setiawan Adib Rifqi
Published: June 2019

This work attempts to identify some areas in which opportunities for better mutual relationship, rather than parasitism, between mathematics and physics in the actual learning activities to reducing students’ cognitive load also educators’ difficulties managing their teaching.
Propuesta teórica para la categorización y el etiquetado semántico de los archivos familiares a través del Fondo Kati
Authors: Martínez de Lahidalga Joseba
Published: June 2019

ENGLISH: The recent trend that is increasing the visibility and preservation of family archive is producing a new challenge for archivists. Because as well as they ensure the management and physical conservation of this type of archives they have to introduce and manage them in digital apps. It is for these reasons that it is absolutely necessary the set up of a new methodology that not only arranges the digital archives but also corrects their deficiencies. Consequently, through a real case, the Kati family archive, two procedures are proposed, precisely the categorization and semantic tagging. Which there are focused on solving some of the difficulties that are generated after digitalization and facilitate the preservation and dissemination of the files in digital environments.SPANISH: La reciente tendencia que está incrementando la visibilidad y la preservación de los archivo familiares está produciendo un nuevo desafío para los archiveros, ya que además de procurar la gestión y conservación física de esta tipología de archivos, tienen que introducirlos y administrarlos en las aplicaciones digitales. Siendo necesaria la constitución de una nueva metodología que no solo ordene sino que también corrija las carencias de los ficheros digitales. En consecuencia, por medio de un caso real, el archivo familiar Kati, se plantean dos procedimientos, la categorización y el etiquetado semántico, enfocados a resolver algunas de las dificultades que se generan tras la digitalización y que facilitan la preservación y divulgación de los archivos familiares en entornos digitales.
Expectativas hacia el alcohol en jóvenes universitarios y propuestas comunicacionales
Authors: Acosta Pérez Cristina Paola , Jimenez Sánchez Alvaro , Barba Guzmán Carmen Variña
Published: June 2019

Introducción: Examinar el consumo de alcohol en una sociedad universitaria hace posible intervenir con rigor en aquellos fallos y conocer los factores que pueden promover o desalentar dicho uso en los estudiantes. Los jóvenes se caracterizan por estar atravesando una etapa evolutiva física-psicológica de gran interés, y a su vez, inmersa en un entorno sociocultural cambiante como es el paso de la secundaria a la universidad, superar la mayoría de edad y un estilo de vida abierto a nuevas experiencias como puede ser el consumo alcohólico.

Objetivo: Analizar la ingesta alcohólica en jóvenes estudiantes (18 a 25 años).

Material y Métodos: Se realizó una investigación cualitativa, se aplicó un cuestionario a 213 alumnos de la Universidad Técnica de Ambato, provincia Tungurahua, en el centro de la sierra ecuatoriana, para evaluar los aspectos relacionados con la ingesta alcohólica.

Resultados: Los resultados muestran la importancia del grupo de pares y la percepción de control en los consumidores de alcohol, así como también se observan expectativas relacionadas con el placer, el estímulo sexual o la facilitación social.

Conclusión: Es importante elaborar propuestas comunicacionales para solucionar los problemas relacionados con la ingesta alcohólica para mejorar la salud de la población
Determinantes de salud que influyen en la adherencia al tratamiento en pacientes con hipertensión arterial en Latinoamérica
Authors: Carrillo Bayas Gabriela Patricia
Published: June 2019

Introducción: La adherencia terapéutica en enfermedades crónicas como la hipertensión arterial es un problema latente en nuestro país. Por lo que es esencial conocer los determinantes de salud que influyen en este proceso, para de desarrollar una educación sanitaria en la atención primaria de salud como en todos los niveles asistenciales, para una mejor adherencia al tratamiento farmacológico e higiénico dietético. 

Objetivo: Identificar los determinantes de salud que influyen en la adherencia terapéutica de personas con hipertensión arterial en los países de Latinoamérica a partir de una revisión sistemática de la literatura científica.

Material y Métodos: Revisión bibliográfica basada en la metodología Prisma. La técnica utilizada para la recolección de datos fue la búsqueda de artículos publicados en las bases de datos Pubmed, Medline, Elsevier, Scielo, Scopus, Google Académico, en las temáticas: Adherencia Terapéutica,  Hipertensión Arterial y Determinantes de salud en Latinoamérica durante el periodo 2015-2018.

Resultados: Se analizaron 20 artículos a doble ciego los cuales cumplieron con los criterios de inclusión, donde se evidencia una baja adherencia al tratamiento de la Hipertensión Arterial las cuales son provocadas por determinantes socioeconómicos, relacionados con el equipo de salud y relacionados con el paciente y la enfermedad. Conclusión: La adherencia terapéutica es un proceso complejo que está determinado por factores: socioeconómicos, relacionados con la asistencia sanitaria, la enfermedad, el tratamiento y el paciente, por lo cual se debe trabajar en cada uno de estos determinantes en conjunto con la política pública de salud para una mejor adherencia terapéutica, evitando complicaciones al pac iente y disminuyendo los gastos al estado.

Conclusiones: La adherencia terapéutica es un proceso complejo que está determinado en lo fundamental por los siguientes  factores: socioeconómicos, los relacionados con el equipo de salud y asistencia sanitaria, la enfermedad, el tratamiento y el paciente.
Clinical practice of mininally invasive gynaecological surgeries
Authors: Bhandari Binaya Raj , Shrestha Ranjana , Pradhan Binita
Published: June 2019

Introduction: Endoscopic gynaecological surgery which is a routine practice in outer world since last 40 years, is still at earlier phase in Nepal. This study was done to know the clinical practice of minimally invasive gynaecological surgeries in Minimally Invasive Diagnostic and Therapeutic (MIDAT) hospital.

Methods: A hospital based descriptive study was conducted in gynaecological department of MIDAT hospital over 16 months period from 1st Bhadra 2071 to 30th Poush 2072 (17th August 2014 to 14th January 2016) among 115 women who underwent minimally invasive gynaecological surgeries (MIGS). Patient demographics, types of surgeries, indications of laparoscopy and hysteroscopy, reason for laparoscopic conversion, complications of surgeries and hospital stay were analyzed.

Results: There were total 115 minimally invasive gynaecological surgeries done in MIDAT hospital during study period. Laparoscopic gynaecological surgeries and hysteroscopy were performed in 86 (75%) and in 29 (25%) women respectively. Among laparoscopy, laparoscopic hysterectomy {31 (36%)} was the more common operation. During laparoscopy, conversion to open was done in nine (10.5%) patients. Complications of MIGS were seen in three (3.5%) women.

Conclusions: MIGS has acceptable morbidity, smooth post operative recovery and shorter hospital stay. In recent time, MIGS is gradually becoming popular in Nepal.
Treatment of advanced rectal cancers: Cylindrical abdominoperineal excision of rectum
Authors: Lamichhane Nirmal , Walker Kenneth G.
Published: June 2019

Introduction: Treatment for patients with locally advanced low lying rectal cancer differs significantly from patients with rectal cancer restricted to the mesorectum. They require multimodality treatment, including preoperative chemo-radiation and extended surgical resection. Cylindrical abdominoperineal excision of rectum (C-APER) along with possible composite pelvic organ resection is a surgical method to remove an adequate circumferential margin.

Method: Patients with the diagnosis of advanced rectal cancers over a period of 9 months are included in this study. Therapeutic approach of C-APER is taken for these patients with focus on multimodality treatment protocols to downstage the tumours and extended resections to enable complete removal of all tumour tissue with clear surgical margins. Consecutive review of cases of advanced rectal cancer to their immediate surgical outcome were done.

Results: Five patients with compromised CRM in MRI of rectum, 4 were treated with Neoadjuvant FOLFOX 6 regimen chemotherapy 3 cycles and Short course Radiotherapy. All underwent surgery 6-8 weeks after treatment. The pelvic floor was repaired with biological mesh in 1 and synthetic mesh in 4. The pathological stage of disease remained T3 and above despite neoadjuvant treatment in majority of patients but none of them had positive CRM. The wound complication rates were high in the perineum with serous discharge in almost every patient and one patient needing long term vacuum assisted dressing in the community.

Conclusion: The surgery is technically feasible with acceptable morbidity in short term with possible long term outcome of reduced loco-regional failure.
Of a Love beyond Repair: Gender, Eros and Ethos in Ovid’s Narcissus (Met. 3.339-510)
Authors: Richardson T. Wade
Published: June 2019

Ovid’s tale of Narcissus shares associations of erotic strangeness with the accounts of Iphis, Byblis, and Salmacis. Iphis and Byblis are distraught at breaching society’s norms with their lesbian and incestuous passions, respectively, while Salmacis’ amphibious sexual perseverance brings about an intriguing natural marvel. As for Narcissus, who loves a boy like himself who turns out to be himself, his contribution to strangeness lies, outwardly, not so much in the visualized object of his romantic obsession (though this would be present in spades) as in the mistaken but opportune milieu of its pursuit. And here the poet–narrator turns pointedly away from commenting upon the obvious homoerotic imprint of Narcissus’s posture. Why? Perhaps because Ovid is after bigger game: love itself. In crafting a convincing and daring de novo love affair between boy contemporaries (with a side look at Echo), he seeks to play experimentally with how the universal standard of successful heterosexual romance, mutual love, will work in a homosexual setting; and for this he needs to have his lovers, boy and boy-image, escape the notoriously nonmutual contamination of classical pederasty.
Perawatan Infeksi Saluran Pernafasan Akut (ISPA) pada Balita
Authors: Padila Padila , Febriawati Henni , Andri Juli , Dori Rujung Ali
Published: June 2019

This study aims to determine the relationship between knowledge and attitudes of mothers with the treatment of Acute Respiratory Infection (ISPA) in children under five in the work area of ​​the Kembang Seri Public Health Center, Talang Empat District, Central Bengkulu District 2018. This type of research is an analytical survey with a cross sectional approach. The results of the univariate analysis research were obtained from 51 respondents, most of the respondents had low knowledge of 21 people (41.2%). While most of the respondents had a bad attitude as many as 27 people (52.9%). Meanwhile, the results of the bivariate analysis of the relationship between knowledge and attitudes of mothers with ARI care in toddlers with the Pearson Chi-square test showed that the p_value for knowledge and attitudes of mothers with ARI care was 0.000 ≤ α 0.005, meaning that there was a significant relationship between knowledge and attitudes of mothers with ARI care in toddlers. in the working area of ​​the puskesmas. Conclusion, the participation of parents, especially mothers, in participating in health promotion activities at the health center must be scheduled.

 

Keywords: Knowledge, ARI Treatment, Attitude