bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between Osteoporosis and Skeletal Muscle Mass in Men
Authors: Mizutani Masaya , Eguchi Yawara , Toyoguchi Toru , Orita Sumihisa , Inage Kazuhide , Shiga Yasuhiro , Maki Satoshi , Nakamura Junichi , Hagiwara Shigeo , Aoki Yasuchika , Inoue Masahiro , Koda Masao , Takahashi Hiroshi , Akazawa Tsutomu , Ohtori Seiji
Published: January 2024

Study Design: Cross-sectional study.Purpose: This cross-sectional study aimed to investigate the risk factors for osteoporosis in men by assessing bone mineral density (BMD), skeletal muscle mass, body fat mass, grip strength, and advanced glycation end products (AGEs).Overview of Literature: Fewer studies have reported the correlation between BMD and skeletal muscle mass in women. Moreover, a few studies have examined the relationship between osteoporosis and skeletal muscle mass.Methods: This study included 99 men (mean age, 74.9 years; range, 28–93 years) who visited Qiball Clinic for BMD and body composition examinations. The osteoporosis group consisted of 24 patients (mean age, 72.5 years; range, 44–92 years), and the control group consisted of 75 individuals (mean age, 74.9 years; range, 28–93 years). Whole-body skeletal muscle mass was measured using a bioelectrical impedance analyzer. BMD was measured by dual X-ray absorptiometry. Skin autofluorescence (SAF), a marker of dermal AGE accumulation, was measured using a spectroscope. Osteoporosis was defined as a bone density T score of –2.5 or less. Physical findings, skeletal muscle mass, BMD, grip strength, and SAF were compared between the osteoporosis and control groups.Results: The osteoporosis group had significantly lower trunk muscle mass (23.1 kg vs. 24.9 kg), lower leg muscle mass (14.4 kg vs. 13.0 kg), and skeletal mass index (7.1 kg/m2 vs. 6.7 kg/m2) than the control group (all p<0.05). Lower limb muscle mass was identified as a risk factor for osteoporosis in men (odds ratio, 0.64; p=0.03).Conclusions: Conservative treatment of osteoporosis in men will require an effective approach that facilitates the maintenance or strengthening of skeletal muscle mass, including exercise therapy with a focus on lower extremities and nutritional supplementation.
The complex treatment paradigms for concomitant tethered cord and scoliosis: illustrative case
Authors: Fluss Rose , Lo Bu Riana , Kobets Andrew J , Gomez Jaime A
Published: January 2024

BACKGROUND

Scoliosis associated with tethered cord syndrome is one of the most challenging spinal deformities to manage. Multiple surgical approaches have been developed, including traditional staged and concomitant procedures, spine-shortening osteotomies, and individual vertebral column resections.

OBSERVATIONS

A 10-year-old female presented with congenital kyphoscoliosis with worsening curve progression, tethered spinal cord, and a history of enuresis. The scoliosis had progressed to a 26° coronal curve and 55° thoracolumbar kyphosis. Preoperative magnetic resonance imaging of the spine revealed a tethered cord between the levels of L3–4 and a large kyphotic deformity at L1. The patient underwent laminectomy, during which intraoperative motor signals were lost. A planned hemivertebrectomy at L1 was performed prior to an L4 laminectomy, untethering of the filum terminale, and posterior spinal fusion from T11 to L2. After surgery, the patient experienced transient lower-extremity weakness, with her neurological function improving from baseline over the next 2 months. Ultimately, the goal of this surgery was to halt the progressive decline in motor function, which was successfully achieved.

LESSONS

Much remains to be learned about the treatment of this complicated disease, especially in the setting of concomitant scoliosis. This case serves to exemplify the complex treatment paradigms that exist when attempting to manage this clinical syndrome and that more remains to be learned.
Numbers 5:11–31 as the Old Testament Background for Revelation 8:11
Authors: Siemieniec Tomasz
Published: January 2024

The article examines possible links between the ritual of bitter water, described in Numbers 5:11–31, and one of the aspects of the plague, described as the event following the third trumpet in the Book of Revelation (Rev 8:11). Such a connection has not been analysed by scholars so far. The ritual described in Numbers 5 not only has a legal meaning but it is also the starting point for a theological tradition of understanding adultery as a metaphor for Israel’s unfaithfulness to YHWH. The prophetic texts of the OT use motifs taken from Num 5 to depict the lawsuit that YHWH brings against the unfaithful people. According to the author of this article, the use of the motif of drinking bitter water in Rev 8:11 falls into a similar pattern. This is a ritual performed to reveal the guilt of the sinners described in Rev as hoi anthrōpoi.
"You Were Strangers in the Land of Egypt" (Exod 22:20): Notes on the Attitude(s) towards Foreigners in Ancient Egypt
Authors: Taterka Filip
Published: January 2024

The article discusses various attitudes towards foreigners that can be perceived in ancient Egyptian material. It is argued that there was no single and unchangeable attitude towards foreigners throughout ancient Egyptian history, but instead that Egyptian attitudes to foreigners changed over time due to various historical and social factors. It is also argued that these attitudes reflected a constant nego­tiation between the traditional and stereotypical perception of foreigners as enemies of the Egyptian state and more nuanced approaches in which foreigners could have a number of roles to play in Egyptian society, which often led to significant transformations of Egyptians’ self-identity. Therefore, the traditional image of ancient Egypt as a highly xenophobic culture is called into question.
Роль брадикініну в розвитку COVID-19 та інших захворювань
Authors: Pushkarev V.M. , Kovzun O.I. , Levchuk N.I. , Pushkarev V.V. , Sokolova L.K. , Tronko M.D.
Published: January 2024

Огляд літератури присвячений участі брадикініну (БК) в розвитку коронавірусної хвороби (COVID-19), спричиненою вірусом SARS-CoV-2, та інших патологічних станів, а також можливості застосування деяких препаратів, які впливають на сигналінг вищезазначеного нанопептиду. БК є потужною короткоживучою вазоактивною сполукою, яка діє як вазодилататор і медіатор запалення в різних сигнальних каскадах. Він входить до складу калікреїн-кінінової системи (ККС), що входить до складу системи ренін-ангіотензин-альдостерон (РААС), яка відіграє ключову роль у патогенезі COVID-19. Як фактор ККС, БК залежить від інших компонентів, необхідних для його синтезу та підтримки. Наразі існує гіпотеза, яка свідчить про те, що шлях БК дерегульований у пацієнтів із COVID-19, що призводить до різних ускладнених респіраторних захворювань. Теорії шторму цитокінів і БК пропонують пояснення різноманітності симптомів і систем органів, уражених після інфекції SARS-CoV-2. Наведені в огляді дані свідчать, що БK є молекулою величезного терапевтичного потенціалу, яка заслужено потребує відповідної спрямованої уваги. Встановлено, що наслідком посилення утворення БK єважкі мультисимптомні патологічні зміни при інфекції COVID-19. Оскільки COVID-19 значною мірою впливає на ККС, існує багато медіаторів, які можуть посилювати тяжкість захворювання. Тому, важливим моментом терапії при COVID-19 є модуляція сигналінгу БК. Було показано, що ефекти БK компенсуються за допомогою деяких сполук, які є антагоністами B2R. Фактори БК-шляху та цитокіни, такі як інтерлейкін-6 (IL-6) та IL-1, можуть бутиключовими для використання блокаторів, навіть як допоміжних засобів. Таким чином, щоб запобігти тяжким ускладненням, викликаних COVID-19 та покращити результати лікування цього інфекційного захворювання необхідно проводити фармакологічне таргетування компонентів ККС, пов’язаних із БK, головним чином – кінінових рецепторів.
Application of Probability-based Multi-objective Optimization in Portfolio Investment and Engineering Management Problem
Authors: Zheng Maosheng , Yu Jie , Teng Haipeng , Wang Yi
Published: January 2024

Markowitz's approach could not deal with the overall optimization of both minimizing variance of return rate and maximizing return rate simultaneously due to its short of rational method for handling multi-objective optimization. In this article, a hybrid of the probability-based multi-objective optimization with the uniform design for experiments of mixtures is performed to solve the portfolio investment problem of concurrent optimization of both maximizing return rate and minimizing variance of return rate. The probabilitybased multi-objective optimization is employed to transfer the bi-objective problem of portfolio investment into a mono-objective one with total preferable probability as the goal for the overall optimization of the system in spirit of probability theory, the uniform design for experiments of mixtures is used to perform the subsequent discretization. Project management problem is rather a multi-objective to conduct naturally. The analysis shows the rationality of the hybrid solution.
Reducing Change Resistance
Authors: Leitenbauer Lena Sophie , Sorko Sabrina Romina , Lutz Miriam
Published: January 2024

Abstract: As digitalization progresses, assistance systems in the field of XR are now also increasingly finding their way into industry. This and the advancements in this area make it more and more interesting for industrial companies. However, it is not only the maturity of the technology in the form of hardware and software that is decisive for its use in combination with suitable corporate use cases, but above all the acceptance of the employees who are supposed to integrate this new technology into their everyday work routine. In this context, it is of utmost relevance to identify all necessary stakeholders at an early stage. Therefore, a model for XR implementation projects will be developed to identify stakeholders and derive appropriate measures in terms of change communication and participation.
Development of a Strategy Roadmap for the Widespread Implementation of Extended Reality
Authors: Sorko Sabrina Romina , Lichem-Herzog Christine
Published: January 2024

Abstract: Digital transformation has led to a multitude of new technical solutions. This includes Extended Reality technologies: Hardware and software systems that enrich the real environment with information. The area of application extends to the entire value chain and thus offers great potential for companies. A systematic and holistic implementation strategy is necessary to exploit this optimally. XR solutions often remain prototypes mainly because of lack of knowledge management and missing understanding about the technology. In this respect, this article presents a tool for the systematic, holistic strategic consideration of XR from the vision to the planning of measures. The tool presented combines common methods such as the Strategy Map, the Transformation Map or the Balanced Scorecard. Thus, it does not only offer companies a strategic framework, but also includes concrete measures for a sustainable, successful implementation.
ЛОГІСТИЧНА ГАЛУЗЬ УКРАЇНИ: ЕКОНОМІЧНЕ ЗНАЧЕННЯ ГАЛУЗІ, ВТРАТИ ТА ПЕРСПЕКТИВИ РОЗВИТКУ В УМОВАХ ВІЙНИ
Authors: МОРОЗ Сергій , ЛЕВЧЕНКО Софія
Published: January 2024

Важливу роль в економіці України відіграє ринок логістичних послуг. Логістика – це кровоносна система економіки країни, сукупність операцій, які здійснюються із метою доставки продукту до споживача. Наведена стаття присвячена питанням визначення ролі логістичного сектору у створенні валового внутрішнього продукту національною економікою України. Визначено питому вагу транспорту, складського господарства, поштової та кур’єрської діяльності в структурі валового внутрішнього продукту України. Відмічено про наявність можливостей росту показника питомої ваги галузі логістики у ВВП України, порівнявши даний показник з показниками інших країнах. Проведено аналіз експортно-імпортних операцій України в динаміці, відмічено негативну тенденцію зниження експорту продукції та зростання від’ємного сальдо. Досліджено  структуру експорту та імпорту за видами транспорту у вартісному та фізичному розрізі. Підтверджено, що логістична сфера є одним із важливих складників розвитку національної економіки України від якої залежить розвиток всієї економіки країни, наукового підходу щодо подальшого ефективного розвитку. Визначено втрати авіаційної, водної, автомобільної, залізничної та складської інфраструктури України спричинені військовими діями. Окреслено основні перспективи розвитку транспортної та складської галузі економіки на майбутнє. З’ясовано, що перспективи розвитку ринку логістичних послуг в Україні безпосередньо залежать від термінів завершення війни, в результаті виникає об’єктивна необхідність оперативно перебудовувати логістичну систему, формувати нові ланцюги доставки вантажів, змінювати напрямки торговельних потоків через блокаду українських морських портів та часткову втрату залізничної мережі.
АНАЛІЗ ПРОБЛЕМИ ПІДГОТОВКИ ГІРСЬКИХ ГІДІВ В УКРАЇНІ З УРАХУВАННЯМ ОСОБЛИВОСТЕЙ РЕГІОНУ
Authors: ТИМКО Ірина , РЄПКО Олена , ТИМКО Євген
Published: January 2024

В статті досліджено ставлення гірської спільноти до підготовки гірських гідів в Україні з метою запровадити підготовку гірських гідів з урахуванням побажань та потреб гідів і клієнтів. Щоб розвити цю тему було створено опитування у Google Forms. Перше - для гідів чи інструкторів, друге – для спортсменів чи клієнтів. В опитуванні протягом місяця взяли участь 21 особа які водять людей у гори і 35 осіб які є користувачами цих послуг. Були порушені теми підготовки гірських гідів, підвищення їх кваліфікації. Зроблено опитування які напрямки підготовки гідів, на думку як гідів так і клієнтів, слід включати в програму та яка форма навчання повинна бути і який час. Обговорено чи є необхідність посібників з гірських видів спорту та чи потрібен єдиний реєстр гірських гідів України. Також поміркували які є перспективні напрямки розвитку послуг гірських гідів. В ході опитування було з’ясовано що ті, хто зараз водить людей у гори займаються гірськими видами спорту доволі довго, але рівень майстерності  більшості не високий. Виявили що в навчанні повинні бути присутні такі модулі як альпінізм, скелелазіння і туризм. Важливо отримати і теоретичні і практичні знання, а також мати час на стажування і складати іспити. З точки зору клієнтів гідам важливо підвищити комунікативні та організаційні навички і це також має бути в навчанні. Тому тема підготовки гірських гідів є актуальною і  81% процент опитуваних провідників вважає що курси для інструкторів потрібні і 100% мають бажання підвищити свою кваліфікацію. В Україні є потреба створити багаторівневі курси підготовки гірських гідів. Ті, хто зараз є «провідниками-самоуками» мають бажання підвищити свій рівень майстерності. Є попит на послуги гірських гідів і є напрямки в яких можна розвиватись. Тому можна починати розробляти програму підготовки гірських гідів в Україні.
СОМАТИЧНІ ЗАНЯТТЯ ЯК ЗАСІБ ПОКРАЩЕННЯ ПСИХОФІЗИЧНОГО СТАНУ СТУДЕНТІВ. МОНІТОРИНГ ЧЕТВЕРТОГО ДОМЕНУ MAIA-2ukr
Authors: ГОЛОВАЧ Інна
Published: January 2024

У статті продовжено дослідження інтероцептивного усвідомлення студентів. The Multidimensional Assessment of Interoceptive Awareness — це опитувальник, який використовують провідні фахівці для вивчення інтероцептивного усвідомлення людей різних вікових категорій. Нами було використано останню версію MAIA-2, оприлюднену у 2018 році. Оригінальна анкета містить 8 шкал з відповідними питаннями. У попередній статті було опубліковано дані шкали "Noticing" (навичка помічати). У цій статті опрацьовано наступний четвертий домен «Attention Regulation» (навичка регулювати увагу), а саме здатність підтримувати і контролювати увагу до відчуттів тіла. До уваги студентів було подано 7 питань (Q №16 - Q №22) з варіантами відповідей по шкалі від нуля до п'яти.

В опитуванні взяли участь 50 студентів першого курсу Факультету здоров'я, фізичного виховання і спорту. Вибірка була однорідною за віком. Опитування було проведено за українською версією Багатовимірної оцінки інтероцептивний усвідомлення (MAIA-2ukr).

У роботі були використані наступні методи: аналіз науково-методичної літератури та інтернет-джерел, соціологічний метод (опитування MAIA-2ukr, четвертий домен «4. Attention Regulation» (навичка регулювати увагу), методи математичної статистики. Для статистичної обробки результатів використовувалася програма MS Excel. Рівень інтероцептивного усвідомлення студентів першого курсу визначали за допомогою адаптованої української версії опитувальника Multidimensional Assessment of Interoceptive Awareness (MAIA-2ukr, https://www.researchgate.net/publication/371450735_MAIA-2_UKR_Original_20220824pdf).

Мета дослідження — оцінити навичку регулювати увагу (здатність підтримувати і контролювати увагу до відчуттів тіла) студентів першого курсу Факультету здоров'я, фізичного виховання і спорту.

У домені «Attention Regulation» розглядається дуже важливий аспект інтероцептивного усвідомлення – це увага.

Навичка регулювати свою увагу виникає ще в ранньому дитинстві і розвивається протягом всього життя людини. Від цієї психічної функції мозку залежить сприйняття, мислення і відчуття подразників зовнішнього та внутрішнього оточення людини. Увага забезпечує якісне життя, сповнене свідомості. Аналіз та чітке усвідомлення своїх дій у студентів призводить до удосконалення в цілому процесу фізичного виховання, педагогічного контролю, покращення рівня здоров’я та працездатності.

У подальших працях ми плануємо оприлюднити результати дослідження 4 наступних доменів інтероцептивного усвідомлення.
Procedural Aspects of the Second Additional Protocol to the Council of Europe Convention on Cybercrime
Authors: Moise Adrian Cristian
Published: January 2024

The objective of the second protocol is to strengthen cooperation in cybercrime and the collection of electronic evidence of crimes for specific criminal investigations or proceedings. The article also presents and analyzes the most important procedural aspects related to the second additional protocol to the Council of Europe Convention on Cybercrime regarding enhanced cooperation and the disclosure of electronic evidence. The analysis of the second additional protocol takes into account the provisions of the Council of Europe Convention on Cybercrime.
Reinforcing Convergence in Implementing EU’s New Cohesion Policy Objective: „Europe Closer to Citizens”
Authors: Patrascu Cristina
Published: January 2024

At the core of the EU’s complex agenda stands the Cohesion Policy, which has been renewed for the following stage, namely 2021-2027. The new cohesion policy places great focus on territorial sustainable development, particularly for cities, by introducing a supplementary objective titled “Europe Closer to Citizens”. The present article offers an analysis of the main elements of this renewed agenda on sustainable development of the cities and the instruments to reinforce convergence of its implementation, across European local communities.
Dido’s foundation legend, archetypes of foundation myths in Eurasia and Neomythology in the nineteenth century Balkans.
Authors: Oikonomidis Stavros
Published: January 2024

Dido’s foundation legend of Carthage survives as a basic archetype for numerous foundation legends of Eurasia throughout the Middle Ages. The stratagem of the ox-hide is repeatedly referred as main theme of the foundation of towns, cities, and kingdoms, from the British Islands to the Balkans and eastern Eurasia. By the time of the genesis of the new nation – states in the Balkans the Didonian archetype has been re-proposed in the case of the foundation of the town of Naoussa, in Northern Greece, now with the Ottoman conqueror of the Balkans playing the role of Dido. His name was Gazi Evrenoz Beg, a Greek renegade who appears in a Greek manuscript found in Naoussa with attributes and characteristics taken by the Graeco-Roman vernacular and written tradition. In this article is studied and analyzed the survival of the ancient myth in the modern times focusing on the reproduction of it in the nineteenth century Balkans.
Global Research Trends and Hotspots for Ferroptosis, Necroptosis, and Pyroptosis in Alzheimer’s Disease from the Past to 2023: A Combined Bibliometric Review
Authors: Yeerlan Jianishaya , He Binhong , Hu Xianliang , Zhang LuShun
Published: January 2024

Background:

Alzheimer’s disease (AD) is a genetically intricate neurodegenerative disorder. Studies on “Ferroptosis in AD”, “Pyroptosis in AD”, and “Necroptosis in AD” are becoming more prevalent and there is increasing evidence that they are closely related to AD. However, there has not yet been a thorough bibliometrics-based investigation on this subject.

Objective:

This study uses a bibliometric approach to visualize and analyze the literature within the field of three distinct types of cell death in AD and explores the current research hotspots and prospective research directions.

Methods:

We collected relevant articles from the Web of Science and used CiteSpace, VOS viewer, and Pajek to perform a visual analysis.

Results:

A total of 123, 95, and 84 articles were published in “Ferroptosis in AD”, “Pyroptosis in AD”, and “Necroptosis in AD”, respectively. Based on keywords analysis, we can observe that “oxidative stress” and “lipid peroxidation”, “cell death” and “activation”, and “Nlrp3 inflammasome” and “activation” were the three most prominent words in the field of “Ferroptosis in AD”, “Pyroptosis in AD”, and “Necroptosis in AD”, respectively. Focusing on the breakout words in the keyword analysis, we reviewed the mechanisms of ferroptosis, pyroptosis, and necroptosis in AD. By mapping the time zones of the keywords, we speculated on the evolutionary trends of ferroptosis, pyrotosis, and necroptosis in AD.

Conclusions:

Our findings can help researchers grasp the research status of three types of cell death in AD and determine new directions for future research as soon as possible.
The Effect of Adding Mirtazapine to Quetiapine on Reducing Agitation in Patients with Alzheimer’s Disease
Authors: Sayadnasiri Mohammad , Darvishskandari Sahar , Latifian Maryam , Shariful Islam Sheikh Mohammed
Published: January 2024

Background:

Alzheimer’s disease (AD) is one of the most debilitating diseases in old age, associated with cognitive decline and behavioral symptoms.

Objective:

This study aimed to investigate the effect of adding mirtazapine to quetiapine in reducing agitation among patients with AD.

Methods:

Thirty-seven elderly patients (18 cases and 19 controls) with AD, diagnosed according to National Institute on Aging and Alzheimer’s Association (NIA-AA) criteria, were enrolled at Nezam-Mafi Clinic. Inclusion criteria comprised a minimum of two years post-diagnosis, a Cohen-Mansfield Agitation and Aggression Questionnaire (CMAI) score above 45, and treatment with 100–150 mg of quetiapine. Patients were randomly assigned to receive mirtazapine (15 mg at night, increased to 30 mg at night after two weeks) or a placebo. Cognitive changes were assessed at weeks 0 and 6 using the Mini-Mental State Examination instrument. Furthermore, symptoms of agitation and aggression were evaluated using the CMAI questionnaire at weeks 4 and 6.

Results:

In this study, the mean duration of AD in the control group was 4.68 years, and in the case group, it was 5.05 years. Although the total agitation score showed no significant change at the end of the study compared to the control group, the rate of physical non-aggressive behavior showed a significant decrease ( p <  0.05).

Conclusions:

According to this study, adding mirtazapine to the antipsychotic drug regimen may not be an effective treatment for agitation in AD patients.
Ferroptosis and aerobic training in ageing
Authors: Kordi Negin , Saydi Ali , Karami Sajad , Bagherzadeh-Rahmani Behnam , Marzetti Emanuele , Jung Friedrich , Stockwell Brent R.
Published: January 2024

Ferroptosis is a form of programmed cell death that plays a significant role in causing several diseases such as heart attack and heart failure, through alterations in fat, amino acid, and iron metabolism. Comprehending the regulatory mechanisms of ferroptosis signaling is critical because it has a considerable effect on the elderly’s mortality. Conversely, age-related changes in substrate metabolism and metabolite levels are recognized to give rise to obesity. Furthermore, research has proposed that aging and obesity-related changes in substrate metabolism may aggravate ferroptosis. The suppression of ferroptosis holds potential as a successful therapeutic approach for managing different diseases, including sarcopenia, cardiovascular diseases, and central nervous system diseases. However, the pathologic and biological mechanisms behind the function of ferroptosis are not fully comprehended yet. Physical activity could affect lipid, amino acid, and iron metabolism to modulate ferroptosis. The aim of this study is to showcase the current understanding of the molecular mechanisms leading to ferroptosis and discuss the role of aging and physical activity in this phenomenon.
Ideal presentations and numberings of some classes of effective quasi-Polish spaces
Authors: de Brecht Matthew , Kihara Takayuki , Selivanov Victor
Published: January 2024

The well known ideal presentations of countably based domains were recently extended to (effective) quasi-Polish spaces. Continuing these investigations, we explore some classes of effective quasi-Polish spaces. In particular, we prove an effective version of the domain-characterization of quasi-Polish spaces, describe effective extensions of quasi-Polish topologies, discover natural numberings of classes of effective quasi-Polish spaces, estimate the complexity of the (effective) homeomorphism relation and of some classes of spaces with respect to these numberings, and investigate degree spectra of continuous domains.
Investigating the effect of psychological contract breach on counterproductive work behavior: The mediating role of organizational cynicism
Authors: Ahmed Mohamed Abdelkhalek Omar , Zhang Junguang
Published: January 2024

BACKGROUND: The negative consequences of Counterproductive work behaviors (CWBs) include intentional malfeasance that damages an organization or its employees. These include decreased output, increased costs, decreased employee morale and discontent. When CWBs exist, the company’s reputation and employee turnover rates may suffer. OBJECTIVE: The purpose of this study is to increase the current understanding of PCB and CWBs, as well as the mediating function of OC in this relationship, among higher education employees. METHODS: Using IBM SPSS AMOS, the results of the survey were analyzed. RESULTS: PCB is positively correlated with CWB-O and CWB-I, suggesting that employee perspectives on PCB negatively influence their emotions and contribute to unethical business behavior. This study found that OC mediates the relationship between PCBs and CWBs and that uninformed organization behavior causes employees to be more discouraged and angrier and participate in CWB. CONCLUSIONS: Academic administrators must discover salary and benefit inadequacies to give incentives based on accurate performance reports, taking into consideration their bosses’ PC infractions. Therefore, institutions must promote loyalty and belonging to reduce PCB if it is poorly broken. Managers may lessen employee cynicism by stressing organizational support and listening to and rewarding employees.
Current Status and Challenges in Dementia Care in the Philippines: A Scoping Review
Authors: Anlacan Veeda Michelle M. , Lanuza Pamela Danielle T. , Sanchez Anna Anjelica R. , Jamora Roland Dominic G.
Published: January 2024

Background:

Dementia prevalence is increasing in low- and middle-income countries such as the Philippines.

Objective:

This study aimed to give an overview of dementia care in the Philippines and to identify gaps in terms of local epidemiology, research, financial coverage, diagnostics, pharmacotherapy, manpower, and caregiver support.

Methods:

This scoping review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-analysis guidelines extension for scoping reviews. Six international and two local databases, and government and non-government websites were searched. Data published in the English or Filipino language on dementia epidemiology, research, diagnostics, management, manpower, and training were extracted from the earliest indexed record until June 2022.

Results:

The prevalence of dementia in the Philippines is high and research output on all aspects of dementia is low. Cost is a major barrier as health care coverage is limited, with reliance mainly on out-of-pocket payments, leading to challenges in the proper diagnosis and treatment of dementia. There is a low specialist-to-population ratio, with shortages beyond manpower and training.

Conclusions:

Gaps in dementia care include limited published local data, high healthcare costs, inadequate health financing, and limited manpower.
Molecular Dissection of Herpes Simplex Virus Type 1 to Elucidate Molecular Mechanisms Behind Latency and Comparison of Its Codon Usage Patterns with Genes Modulated During Alzheimer’s Disease as a Part of Host-Pathogen Interaction
Authors: Gurjar Pankaj , Khan Azmat Ali , Alanazi Amer M. , Vasil’ev Vasilii G. , Zouganelis George , Alexiou Athanasios
Published: January 2024

Background: Herpes simplex virus type 1 (HSV-1) is associated with Alzheimer’s disease, which goes into a cycle of latency and reactivation. The present study was envisaged to understand the reasons for latency and specific molecular patterns present in the HSV-1. Objective: The objective is the molecular dissection of Herpes simplex virus type 1 to elucidate molecular mechanisms behind latency and compare its codon usage patterns with genes modulated during Alzheimer’s disease as a part of host-pathogen interaction. Methods: In the present study, we tried to investigate the potential reasons for the latency of HSV-1 virus bioinformatically by determining the CpG patterns. Also, we investigated the codon usage pattern, the presence of rare codons, codon context, and protein properties. Results: The top 222 codon pairs graded based on their frequency in the HSV-1 genome revealed that with only one exception (CUG-UUU), all other codon pairs have codons ending with G/C. Considering it an extension of host-pathogen interaction, we compared HSV-1 codon usage with that of codon usage of genes modulated during Alzheimer’s disease, and we found that CGT and TTT are only two codons that exhibited similar codon usage patterns and other codons showed statistically highly significant different codon preferences. Dinucleotide CpG tends to mutate to TpG, suggesting the presence of mutational forces and the imperative role of CpG methylation in HSV-1 latency. Conclusions: Upon comparison of codon usage between HSV-1 and Alzheimer’s disease genes, no similarities in codon usage were found as a part of host-pathogen interaction. CpG methylation plays an imperative role in latency HSV-1.
E-Tenon: An efficient privacy-preserving secure open data sharing scheme for EHR system
Authors: Gope Prosanta , Lin Zhihui , Yang Yang , Ning Jianting
Published: January 2024

The transition from paper-based information to Electronic-Health-Records (EHRs) has driven various advancements in the modern healthcare industry. In many cases, patients need to share their EHR with healthcare professionals. Given the sensitive and security-critical nature of EHRs, it is essential to consider the security and privacy issues of storing and sharing EHR. However, existing security solutions excessively encrypt the whole database, thus requiring the entire database to be decrypted for each access request, which is time-consuming. On the other hand, the use of EHR for medical research (e.g., development of precision medicine and diagnostics techniques) and optimisation of practices in healthcare organisations require the EHR to be analysed. To achieve that, they should be easily accessible without compromising the patient’s privacy. In this paper, we propose an efficient technique called E-Tenon that not only securely keeps all EHR publicly accessible but also provides the desired security features. To the best of our knowledge, this is the first work in which an Open Database is used for protecting EHR. The proposed E-Tenon empowers patients to securely share their EHR under their own multi-level, fine-grained access policies. Analyses show that our system outperforms existing solutions in terms of computational complexity.
Traversable map construction and robust localization for unstructured road environments1
Authors: Lian Jing , Chen Shi , Li Linhui , Sui Duo , Ren Weiwei
Published: January 2024

Intelligent vehicles require accurate identification of traversable road areas and the ability to provide precise and real-time localization data in unstructured road environments. To address these issues, we propose a system for traversable map construction and robust localization in unstructured road environments based on a priori knowledge. The proposed method performs traversable area segmentation on the LiDAR point cloud and employs a submap strategy to jointly optimize multiple frames of data to obtain a reliable and accurate point cloud map of the traversable area, which is then rasterized and combined with the vehicle kinematic model for global path planning. Then, it integrates priori map information and real-time sensor information to provide confidence and priori constraints to ensure the robustness of localization, and it fuses multi-sensor heterogeneous data to improve real-time localization. Experiments are conducted in a mining environment to evaluate the performance of the proposed method on an unstructured road. The experimental results demonstrate that the traversable map and localization results based on the proposed method can meet the requirements for autonomous vehicle driving on unstructured roads and provide reliable priori foundation and localization information for autonomous vehicle navigation.
Grey markov land pattern analysis and forecasting model incorporating social factors
Authors: Zhang Zhifei , Wang Shenmin
Published: January 2024

The focus of attention has shifted to land use and land cover changes as a result of the world’s fast urbanisation, and logical planning of urban land resources depends greatly on the forecast and analysis of these changes. In order to more precisely forecast and assess patterns of land use change, the study suggests a grey Markov land pattern analysis and prediction model that incorporates social aspects. The study builds a land pattern analysis and prediction model using a major city as the research object. The outcomes demonstrated the high accuracy and reliability of the grey Markov land pattern analysis and prediction model incorporating social factors, which can more accurately reflect and predict the land use pattern of the study area, with an average relative error of less than 0.01, an accuracy of more than 98%, and an overall fit that has increased by more than 3%. The overall pattern of change is very consistent with the reality. The model predicts that the main trend of future land use in the study area is the continued expansion of urban land such as industrial land, land for transport facilities and land for settlements, while non-construction land such as agricultural land and forest land will continue to decrease. The optimized land pattern analysis and prediction model of the study has a good application environment.
Interval-valued intuitionistic fuzzy AROMAN method and its application in sustainable wastewater treatment technology selection
Authors: Alrasheedi Adel Fahad , Mishra Arunodaya Raj , Pamucar Dragan , Devi Sarita , Cavallaro Fausto
Published: January 2024

In the theory of interval-valued intuitionistic fuzzy set (IVIFS), the rating/grade of an element is the subset of the closed interval [0, 1], therefore the IVIFS doctrine is more useful for the decision expert to present their judgments in terms of intervals rather than the crisp values. The present work develops an integrated decision-making methodology for evaluating sustainable wastewater treatment technologies within the context of IVIFS. The proposed decision-making framework is divided into three stages. First, some Yager weighted aggregation operators and their axioms are developed to combine the interval-valued intuitionistic fuzzy information. These operators can offer us a flexible way to solve the realistic multi-criteria decision-making problems under IVIFS context. Second, an extension of Symmetry Point of Criterion model is introduced to determine the criteria weights under IVIFS environment. Third, an integrated alternative ranking order model accounting for two-step normalization (AROMAN) approach is proposed from IVIF information perspective. Next, the practicability and efficacy of the developed model is proven by implementing it on a case study of sustainable wastewater treatment technologies evaluation problem with multiple criteria and decision experts. Finally, comparative analysis is discussed to illustrate the consistency and robustness of the obtained outcomes.
The Importance of Early Treatment of Inherited Neuromuscular Conditions
Authors: Mackels Laurane , Servais Laurent
Published: January 2024

There has been tremendous progress in treatment of neuromuscular diseases over the last 20 years, which has transformed the natural history of these severely debilitating conditions. Although the factors that determine the response to therapy are many and in some instance remain to be fully elucidated, early treatment clearly has a major impact on patient outcomes across a number of inherited neuromuscular conditions. To improve patient care and outcomes, clinicians should be aware of neuromuscular conditions that require prompt treatment initiation. This review describes data that underscore the importance of early treatment of children with inherited neuromuscular conditions with an emphasis on data resulting from newborn screening efforts.
Monoterpenes as Medicinal Agents: Exploring the Pharmaceutical Potential of p-Cymene, p-Cymenene, and γ-Terpinene
Authors: Bagińska Sylwia , Golonko Aleksandra , Świsłocka Renata , Lewandowski Włodzimierz
Published: January 2024

This review highlights the therapeutic propeties of monoterpenes, particularly γ-terpinene, p-cymene, and p-cymenene, found in essential oils derived from various plants. These compounds are known for their analgesic, anticancer, anti-inflammatory, and antimicrobial properties. γ-Terpinene is recognized for its potent antioxidant propeties and is a constituent of oils from plants such as cumin and thyme. p-cymene, found in over 100 plant species, is noted for its antiviral and antibacterial properties and is considered safe by IFRA standards. p-Cymenene, with its distinct aroma, is detected in parsley and turmeric oils and is known for its antibacterial and antioxidant activities. The antimicrobial properties of γ-terpinene and p-cymene are highlighted, demonstrating their effectiveness in treating various skin conditions and reducing airborne microbes. Their selective antimicrobial activity preserves the integrity of the microbiome, offering a balanced approach to infection control. The anti-inflammatory properties of γ-terpinene are emphasized, with studies indicating its role in modulating cytokine production, underscoring its potential in the treatment of inflammation. Additionally, its antinociceptive effects suggest that it is a safe analgesic. In cancer treatment, the antiproliferative effects of γ-terpinene and p-cymene are being explored, highlighting their potential for targeted cancer therapy. This review aims to consolidate knowledge about these monoterpenes and promote a deeper understanding of their medical applications and safety. The knowledge gained is expected to stimulate further research, potentially leading to innovative applications in pharmaceutical and medical fields and harnessing the potential of -terpinene, p-cymene, and p-cymenene.
2D Inversion of DC Resistivity Method to Detect High-resistivity Targets inside Dams
Authors: Li Maofei , DAI Qi , Liu Shucai , Liu Yaoning
Published: January 2024

As the first barrier of flood control, the integrity and continuity of dams are of the utmost importance. However, with the influence of natural weathering, running water erosion, and humanistic factors, various degrees of damage are prone to occur inside and outside dams. Therefore, it is necessary to detect the integrity of dams and evaluate their flood control capacity. Different from the previous detection of water-filled imperfect areas, we used numerical simulation and measured data analysis and considered the influence of actual noise to conduct DC resistivity detection and 2D inversion research on the high-resistivity imperfect areas existing in dams. The research results show that both the calculated apparent resistivity and the resistivity obtained by 2D inversion deviate from the real resistivity of the dam. A dam with a height less than 5 m has a relatively small influence on the 2D inversion results of the DC resistivity method, and the inversion results can accurately show the spatial information of the high-resistivity imperfect areas. The distance between the river and dam has a major influence on the inversion results, but the influence on the inversion results can be ignored when the distance is greater than 20 m in the model of this paper. The 2D inversion of the DC resistivity method can be used to detect high-resistivity imperfect areas of dams, and the 2D spatial information of the 3D geological bodies can be accurately obtained.
Tricuspid insufficiency: from anatomy to function
Authors: Zamorano Gómez J.L.
Published: January 2024

Tricuspid regurgitation (TR) is a common finding during echocardiographic examination. It is undoubtedly a disease with a poor prognosis. One-year survival has been reported for patients with severe TR of 63% regardless of other concomitant conditions such as reduced left ventricular ejection fraction or increased pulmonary artery systolic pressure. However, data on the prognostic significance according to etiology and quantitative assessment of severity are scarce.
Transthoracic echocardiography is the main diagnostic tool to determine the etiology and severity of TR. Quantitative, rather than qualitative, multiparametric approaches are recommended for assessing TR severity, such as estimation of vena contracta, effective regurgitant orifice, and regurgitant jet area. However, a recent trial on the feasibility of transcatheter devices has shown that the current classification of TR may fail to stratify patients with TR of a “torrential” nature, who appear to have a different prognosis compared to patients with severe IT. A new classification has recently been published based on a quantitative multiparametric echocardiographic evaluation, which includes the degrees of massive and torrential.
Surgical correction of isolated TR continues to be the procedure with the highest mortality among valve surgical procedures. Therefore, data on the prognosis of different types and grades of TR patients are mandatory in order to better stratify our patients and decide the optimal timing for surgery or other procedures.
In this review we summarize the epidemiological, anatomical, diagnostic data and new therapeutic alternatives that exist in this exciting field of tricuspid regurgitation.
Adaptive linear estimation of dynamic measurement error
Authors: Volosnikov A. S.
Published: January 2024

The problem of the dynamic measurement error estimation and compensation is considered. This type of error is determined by two components. The first one is due to dynamic properties (inertia) of a sensor. The second one is due to the presence of an additive noise at the sensor output. An approach to estimate and reduce the dynamic measurement error based on the signals adaptive linear prediction or adaptive line enhancement principle is proposed. The approach consists in generating a dynamic measurement error estimation signal based on comparing a delayed copy of the recovered signal with the recovered signal passed through an adaptive non-recursive filter with a linear phase characteristic. The structure of a measuring system with an adaptive linear estimator of the dynamic measurement error based on this approach has been developed. A computer simulation of the proposed measuring system for the second-order sensor is carried out. Optimal (in the sense of the mean squared deviation of the dynamic error) orders of the restoring adaptive filter are obtained in the presence of additive harmonic noise of variable frequency at the sensor output. The properties of the proposed measuring system with the dynamic measurement error estimator adaptive to the noise parameter are demonstrated. The application field of the results obtained is the measurement data processing of fast-changing processes (including real-time mode), when the component of the dynamic measurement error, caused by dynamic properties (inertia) of the sensor, as well as additive noises at its output, is dominant. The solution of such a problem is relevant, for example, when processing the results of ground tests of space technology.
Analysis of optimization methods for nonparametric estimation of probability density in large volume samples
Authors: Lapko A. V. , Lapko V. A.
Published: January 2024

A method is proposed for selecting the blurriness coefficient of kernel functions for nonparametric estimation of the probability density of a one-dimensional random variable with large volumes of statistical data, for example, obtained by remote sensing of natural objects. In the proposed method for selecting the blurriness coefficient, a regression estimate of the probability density is used. A method for synthesizing a regression probability density estimate is presented. The synthesis of the estimate is based on compression of the initial sample by decomposition of the range of values of a random variable. To decompose the range of values of a random variable, the Heinhold-Gaede rule and the formula for optimal selection of the number of sampling intervals are applied. Two approaches to the selection of the blurriness coefficient of the regression estimation of probability density using the traditional and proposed by the authors optimization methods of nonparametric estimation of probability density are considered. The traditional method of optimizing nonparametric estimation of probability density is based on minimizing its mean square deviation. In the proposed method, the selection of the blurriness coefficients of the kernel functions is based on the conditions of the minimum error of approximation of the regression estimate of the desired probability density. The approximation properties of the regression estimation of probability density using two methods of its optimization are analyzed. The conditions of their competence in estimating the probability densities of random variables with a lognormal distribution law are established. The results obtained allow for development when optimizing a regression estimate of the probability density of a multidimensional random variable.