bluuebunny/crossref_metadata_2025 huggingface dataset:
Badania dyskursu wspomagane korpusowo (CADS) jako wsparcie jakościowej analizy treści. Studium przypadku wykorzystania programu SketchEngine w badaniach dyskursu
Authors: Troszyński Marek
Published: December 2024

Artykuł przedstawia możliwość wykorzystania narzędzi lingwistyki korpusowej jako pierwszego etapu jakościowej analizy treści. W tekście omówiony jest rozwój metody badań dyskursu wspomaganych korpusem (CADS). Zasadnicza część artykułu to omówienie funkcji wybranego programu wspomagających CADS – SketchEngine. W tekście znajdziemy liczne przykłady, które objaśniają sposoby wykorzystania metod CADS i funkcjonalności SketchEngine dla analizy polskiego dyskursu prasowego. Dzięki możliwości łatwego odniesienia do tekstów źródłowych (konkordancje) SketchEngine pozwala na włączenie metod mieszanych do badań dyskursu.
Shadowing as a Method of Monitoring the Museum Experience of People with Disabilities: Toward a Comprehensive Multimodality Design
Authors: Żuchowska-Skiba Dorota , Olszewska Anna
Published: December 2024

The article explores the challenges associated with ensuring accessibility in museums for visitors with various disabilities. The analysis encompasses strategies for implementing technology and universal design to enhance accessibility while preserving esthetic and informational values. The study highlights multimodality as a promising solution integrating different forms of reception within museum collections. Research conducted at the Czartoryski Museum, a branch of the National Museum in Kraków, gathered experiences and opinions from visitors with disabilities regarding current accessibility solutions. The findings suggest that modern museums should offer multiple access channels to meet diverse needs, enabling visitors to effectively utilize resources. Additionally, the engagement of individuals with disabilities in evaluating and co-creating accessible solutions is crucial, as their input provides valuable and constructive insights. These conclusions emphasize the necessity of taking action toward inclusivity, which may contribute to redefining accessibility strategies in museums worldwide.
A study of diseases in geriatric dogs
Authors: Jain* Sanjeeta , Patel P.R. , Raval S.K.
Published: December 2024

This study on aspect of the prevalence of disease in geriatric (10 years old) dogs was undertaken in Veterinary College Hospital Anand. A total of 156 geriatric dogs including 82 male and 74 female were selected. Among all, prevalence of gastrointestinal problems (16.66%) was higher followed by wound (14.10%), eye problems (14.10 %) and tumour (12.17%). The prevalence rate of ear infection, dental problem, respiratory infection, behavior abnormalities, renal problems and liver problems were 4.48 %, 7.6%, 5.12%, 7.06%, 3.84% and 4.48% respectively.
‘COVID sucked the soul out of all things decent’:
Authors: McGlynn Chloe , Finneran Lana , McKenzie Karen , O'Shea Clara
Published: December 2024

The COVID-19 restrictions had a significant impact on higher education in the UK, with the majority of teaching moving to online delivery. We conducted semi-structured interviews with 16 students who were studying at universities across the United Kingdom in order to explore student experiences of digital teaching in the wider context of the COVID-19 pandemic restrictions. Thematic analysis was used to analyse the results. Two key themes with associated themes were identified. The first theme explored students’ experiences of the move to e-learning, the support that was offered, and the perceived impact on their academic performance. The second theme explored the wider impact on students, in relation to opportunities for work experience, social relationships, future prospects, and mental health. The results illustrated that the sudden move to online learning left many students feeling disengaged from their learning; worried about their future prospects, socially isolated and experiencing poorer mental health. Implications for the provision of online education are discussed
A PERFORMANCE COMO POSSIBILIDADE DE RESSIGNIFICAÇÃO DE RELAÇÕES ÉTICO-POLÍTICAS FOMENTADAS NO CONTEXTO DA ESCOLA BÁSICA
Authors: Gomes Sidmar Silveira , Oliveira de Sousa Charlie Wilson
Published: December 2024

Este texto reflete sobre o processo de realização da performance A quem cabe o futuro do país?, concebida a partir da dramaturgia Conselho de Classe, de Jô Bilac, e apresentada no Colégio de Aplicação Pedagógica da UEM. Em diálogo com estudiosos/as dos campos da Pedagogia do Teatro e da Performance, buscou-se refletir sobre os possíveis efeitos das performances artísticas nos contextos da escola básica. Apresenta-se como um desses efeitos a possibilidade da instauração de processos de ressignificação, tais como das expectativas das práticas artísticas no contexto escolar, da ideia de educação, das relações com os espaços e os sujeitos da escola e das condutas ético-políticas que ligam a escola à macro sociedade que a envolve.
SARUBBI
Authors: Smith Francisco , Athayde Bordallo da Silva Mariana Tereza
Published: December 2024

Este artigo tem por objetivo apresentar a biografia do artista plástico bragantino Valdir Sarubbi e as fases artisticas de um amazônida a partir das memórias afetivas e culturais. Para isso, explorar-se-á os dados de suas produções, lembranças  do artista no período em que ele ainda vivia em Bragança e em Belém. Para isso, foram utilizados os depoimentos do próprio artista que aparecem no livro de Rosana Bitar (2002); e, a carta escrita pelo artista a seus primos após a morte de sua tia Sabazinha.
Perspective as structured memory in the wake of the Great Plague of 1348
Authors: Grillo Michael
Published: December 2024

The Great Plague of 1348 prompted a cathartic shift in thinking about cities, from organic social networks of individuals, to the remaining buildings indexing the memory of their lost residents. The profound impact of such population loss forced survivors to engage the Classical device of Memory Theater, remembering people by their spatial locations rather than their bodily presence. Engaging this public sensibility, the Trecento reconceptualized how pictorial structure, from one centered around protagonists to a standardized compositional system placing each figure in clearly mapped relationships, serving what Leon Battista Alberti would later deem the primary purpose of painting: clear narration, istoria. Displacing subjects for their spatial relations, this new compositional scheme of perspective offered a mimetic form in which painters of the Quattrocento could then explore how to articulate the capacities of historical memory itself. From the chaos of pestilence emerged one of the definitive design elements, one of rationalized narrative space, core to Renaissance vision.
A human artist in a posthuman world: Reflections on artmaking and deskilling in the Anthropocene
Authors: Kolenda Karolina
Published: December 2024

This paper discusses the work of the Polish artist Diana Lelonek as an investigation of a possible skillset for the Anthropocene-era artist. An outline of the reflection on deskilling in arts serves to illuminate the process whereby artistic skills are dismissed in favour of other skills. The main argument is that the transformation of the idea of artmaking in late capitalism has accelerated in recent decades with the advent of environmental humanities and posthumanism, which posit the necessity of formulating a vision of artistry that moves beyond the artist’s human perspective in order to include non-human subjects. The text refers also to the theory and practice of sustainable design to show that the idea of deskilling as a strategy for the Anthropocene intersects among many disciplines.
Análise das Expectativas em Consultas de Rotina: Estudo Transversal em Portugal
Authors: Bica Tavares Maria Manuel , Rosendo Carvalho e Silva Inês , Santiago Luiz Miguel
Published: December 2024

Introdução: A medicina preventiva é tema de estudo dada a crescente evidência de poder causar mais dano que benefício, sendo amplamente reconhecido o interesse da população em ter consultas de rotina. O objetivo principal deste estudo foi conhecer as expectativas dos utentes relativamente às consultas de rotina nos cuidados de saúde primários e compará-las às perceções dos médicos relativas a essas expectativas.Métodos: Foi realizado um estudo observacional transversal, em 2023, aplicando dois questionários: um para utentes adultos e outro para médicos de família. Os convites para resposta ao questionário via Google Forms foram disseminados em redes sociais específicas. Para utentes idosos, realizou-se aplicação presencial por um dos investigadores. O questionário era composto por 25 questões sobre atitudes preventivas na consulta, exames analíticos e sua periodicidade e recomendações de acordo com o sexo e a idade, diferindo na linguagem utilizada.Resultados: Obteve-se uma amostra de 225 utentes e 100 médicos de medicina geral e familiar. Os utentes selecionaram em média 7,8 ± 9,7 atitudes preventivas na consulta e os médicos julgaram que eles teriam selecionado 4,6 ± 2,9 (p = 0.001). A auscultação cardíaca e pulmonar (82,6%), a quantificação de exercício físico (74,7%) e a avaliação de hábitos tabágicos (72,9%) foram as medidas mais selecionadas pelos utentes, sendo os exames mais selecionados a medição da glicemia (81,8%), o perfil lipídico (80,4%) e a análise da urina (75,1%). Para 68,2% dos utentes, a consulta de rotina deveria ser anual, tendo 88,0% dos médicos julgado que os utentes pretenderiam essa periodicidade. O nível socioeconómico populacional não influenciou significativamente os resultados.Conclusão: É importante que os médicos de medicina geral e familiar tenham conhecimento das expectativas dos utentes. Nesta amostra, os utentes demonstraram valorizar um maior número de atitudes médicas preventivas na consulta e mais testagem periódica analítica do que o antecipado pelos médicos. Os médicos acreditaram ainda que os utentes demonstrariam maior interesse na realização frequente de programas de rastreio.
Aphasia Screening Test (TeRAp): Construction and Validation for European Portuguese
Authors: Fonseca José , Miranda Filipa , Stein Beatriz , Maruta Carolina
Published: December 2024

Introduction: Aphasia is a common acquired language disorder following stroke or other brain injuries. However, it is not always easy to make a differential diagnosis with another communication disorder. Communication assessment in acute phases of the stroke, when the patient is bedridden or when there is no time for a more in-depth assessment, needs to be done with a formal screening test that has normative data. The aim of this study was to develop the Aphasia Screening Test (TeRAp) in digital format (appWeb) and present its clinimetric values.Methods: A screening test (TeRAp) was built in appWeb format that assesses the main areas of language processing and automatically provides a diagnostic hypothesis. A group of people with aphasia was evaluated and their performance was compared with three control groups, one of healthy people and two groups of people with neurological conditions, one with dysarthria and the other with mild cognitive impairment.Results: Ceiling values were obtained in all the tests. Sensitivity values of 1 and specificity values of 0.99 were obtained for the presence of aphasia. Conclusion: An online aphasia screening test was developed, with excellent sensitivity and specificity results, which can be used by any health professional.
Comment on the Article “Burnout Among Portuguese Residents: A Case for Change”
Authors: Galvão Montenegro Gabriela , Peixinho-Pernadas Bernardo
Published: December 2024

N/A
Kualitas Organoleptik dan Kandungan Gizi Kerupuk Ikan Lokal (Bleberan) Formulasi sebagai Camilan untuk Balita Stunting
Authors: Mahyuddin Meriwati , Rizal Ahmad , Afrizal Afrizal
Published: December 2024

Latar Belakang: Permasalahan gizi pada balita sering diakibatkan oleh beberapa faktor yaitu faktor langsung, tidak langsung, faktor utama dan faktor dasar. Stunting merupakan masalah kekurangan gizi kronis pada balita yang dapat berdampak jangka panjang maupun jangka pendek. Sebagian besar wilayah Kota Bengkulu terletak di pesisir yang kaya hasil laut. Beberapa ikan kecil dan relative murah merupakan hasil sampingan.
Tujuan: Tujuan dari penelitian ini adalah menilai uji hedonik kesukaan kerupuk dengan variasi sayuran (sawi hijau, wortel, dan tomat apel).
Metode: Penelitian dilakukan di Laboratorium Gizi selama 1 bulan dimulai dari pembuatan produk hingga uji organoleptik dan uji daya terima pada masyarakat di Puskesmas terpilih dengan kriteria puskesmas stunting tertinggi (Puskesmas Pasar Ikan, Puskesmas Beringin Raya, Puskesmas Sawah Lebar, Puskesmas Penurunan, Puskesmas Anggut Atas, Puskesmas Sukamerindu, serta Puskesmas Jalan Gedang). Penelitian ini merupakan Eksperimen Rancangan Acak Lengkap (RAL). Analisis data menggunakan aplikasi Stata 16 diawali analisis univariat (proporsi dan rata-rata).
Hasil: Kerupuk ikan dengan formulasi tomat apel masing-masing bahan dasar ikan 250 g dan tomat apel 50 g menunjukkan rata-rata skor kesukaan tertinggi dan mengandung 424,42 kkal dan 0,96 g rotein. Secara statistik perbedaan ditunjukkan oleh  mutu organoleptik warna, dengan tingkat kemaknaan p-value=0,008.
Kesimpulan: Formulasi kerupuk ikan bleberan dengan variasi tomat menunjukan skor kesukaan tertinggi dengan nilai rata-rata  3,83, dengan perbedaan bermakna pada mutu uji organoleptik warna.
Pembatalan Konser di SXSW Sebagai Langkah Diplomatik Grup Musik Reality Club dalam Respon Konflik Israel-Palestine
Authors: SUWARTO VISNU
Published: December 2024

Di tengah konflik Israel–Palestina yang belum mereda, satu langkah berani dilakukan oleh grup musik asal Indonesia, Reality Club. Band yang berasal dari Jakarta tersebut memberikan dukungan kemanusiaan kepada Palestina dengan membatalkan rencana konser mereka di SXSW, sebuah tempat perhelatan seni yang ada di Austin, Texas, Amerika Serikat. Reality Club yang sedang melakukan tour di Amerika Utara tersebut membatalkan rencana show mereka di SXSW karena ditemukan fakta bahwa SXSW didanai oleh angkatan darat Amerika Serikat yang memberikan bantuan besar kepada Israeli Defence Force atau tentara Israel yang melakukan genosida terhadap rakyat Palestina di Gaza. Dengan adanya pembatalan tersebut membuat Tour yang sedianya telah berjalan empat dari delapan kota dan menyisakan empat kota lagi, berkurang dengan hanya menjadi tiga kota, yaitu di Chicago, Toronto (Kanada) dan Brooklyn. Langkah diplomasi yang dilakukan oleh Reality Club merupakan salah satu bentuk kajian dalam Hubungan Internasional yang bernama Power Mass Movements. Reality Club, dalam hal ini memposisikan diri mereka sebagai penggerak dalam power mass movements yang mana Reality Club, sebagai musisi yang berpengaruh di Indonesia serta memiliki pengikut yang besar dari sosial media melihat bahwa mereka dapat menggunakan previlege mereka untuk menyuarakan kebenaran.
Kata Kunci: SXSW, Langkah Diplomatik, Israel – Palestina, Gaza.
Cooperation Between Indonesia Battery Cooperation (IBC) and Hyundai on the EV Battery Project in Indonesia as A Form of Renewable Energy Solution in Response to Climate Change
Authors: Astuti Widi , Putra Ferdian Ahya Al
Published: December 2024

Energy frequently relates to bring up in relation to the Net Zero Emissions 2060 target. Finding a way to achieve zero carbon emissions with an energy sustainability solution in line with the seventeen Sustainable Development Goals (SDGs) is the goal. Indonesia and other nations follow the Energy Trilemma, which emphasized three primary factors—energy security, energy affordability, and sustainable energy—to become factors that are taken into account for planning and history in order to address all social, economic, and environmental aspects. More precisely, taking into consideration the capacities of both countries, South Korea and Indonesia have proposed several strategic alternatives, one of which is the EV battery project development strategy. In addition to resources and other forms of strategic support, South Korea invests in, owns, and controls technology for Indonesia. Indonesia is able to meet 52% of the world’s nickel demand. This study examines how the Hyundai consortia and the Indonesian Battery Corporation consortia worked together to build an EV battery project in Indonesia, which had an impact on both nations to achieve the solution of how to be one of the renewable energy solutions in response to climate change.
Keywords: EV Battery; Trilemma Energy; Global Value Chain; Hyundai; IBC.
Degrowth Analysis on Indonesian International Tourism Destinations
Authors: Nuryananda Praja Firdaus , Rudiany Novita Putri , Najaf Abdul Rezha Efrat , Mawardi Alfiandi Imam , Hamdan Arva Rizqullah , Bilqis Thufailah Nafiisah , Zein Isynariyah
Published: December 2024

Greenwashing has become prevalent as many stakeholders falsely claim to adhere to green growth principles. Green growth also often neglects human rights aspects. This study proposes degrowth as an alternative to the dominant economic growth paradigm. Degrowth, which gained popularity during the post-pandemic recovery, emphasizes sustainability, justice, and independence from capitalist growth. While green growth often relies on technology for solutions, degrowth recognizes its potential limitations. In the Global South, degrowth can support local communities and challenge neo-colonial tourism practices. Community-based tourism, slow tourism, and responsible tourism are concrete manifestations of degrowth principles. These approaches aim to benefit local communities, reduce environmental impact, and promote sustainable tourism practices. This study focuses on three Indonesian international tourism destinations, Raja Ampat, Nusa Penida, and Labuan Bajo. By analysing the discourses surrounding these destinations, the study highlights the need for a transformative shift towards more sustainable and equitable tourism practices. Degrowth offers a roadmap for achieving balanced economic growth while prioritizing ecological preservation and social justice.
Keywords: Green Growth, Degrowth, Sustainability, Justice, Tourism.
A pilot translation and adaptation of the Diabetes Obstacle Questionnaire (DOQ) to measure obstacles and challenges in diabetes management for people with diabetes in Indonesia
Authors: Kusumaningrum Niken Safitri Dyan , Handayani Fitria
Published: December 2024

Introduction: Identifying the issues faced by Indonesians living with diabetes is crucial to address them appropriately. However, a standardized tool cannot measure the obstacles encountered in managing illness. Therefore, there is a need for widely accepted assessment tools to investigate these problems. This article explains the findings of the pilot translation and adaptation of the Diabetes Obstacle Questionnaire (DOQ) for people with diabetes in Indonesia.
Methods: The English version of the DOQ was cross-culturally adapted and translated into Bahasa, Indonesia. The completion of the questionnaire required approximately 30 min for each of the 61 respondents, all of whom were Indonesians diagnosed with diabetes. Factor analysis, product moment, and Cronbach’s alpha were used in STATA SE 13.1 for data analysis.
Results: The original 78 items underwent a systematic process of translation and adaptation to align with the Indonesian context. Twenty-one items were eliminated, leaving 57 valid question items following a judgement of expert and statistical analysis. The reliability coefficient of the Indonesian version of the DOQ was acceptable, with a value of 0.96 for all items. The coefficient varied between 0.82 and 0.99 for different scales, indicating high internal consistency reliability.
Conclusions: The Indonesian version of the 57-item DOQ is an acceptable instrument that can be used to identify obstacles faced by people with diabetes in Indonesia. This can facilitate researchers in investigating the problems faced by those living with diabetes in managing their condition.
Factors, barriers and adherence of nurses to patient education in public hospitals of Lanao del Sur, Philippines
Authors: Omar Naseha M. , Mala Naima D. , Bangcola Ashley A.
Published: December 2024

Introduction: Patient education is a core responsibility in nursing, vital for improving patient understanding and active participation in their healthcare decisions. There are various factors that impact nurses' ability to provide patient education, but little is known about how these factors influence adherence in public hospitals, particularly in resource-limited settings. This study investigates nurses' adherence to patient education protocols in Lanao del Sur, Philippines, while evaluating facilitating factors and barriers.
Methods: This study employed a quantitative, descriptive, cross-sectional correlational research design. Seventy-six nurses from two public district hospitals participated. Data were gathered through surveys on demographics, adherence to patient education, facilitators, and barriers. Correlation analyses, including Pearson’s correlation and Spearman’s rho, assessed relationships between variables, with Cramer’s V used for categorical data. Statistical significance was set at α = 0.05.
Results: Most participants were married females aged 31-40, with incomes of 10,000-39,000 PHP, college-educated, and assigned to wards, with 3 months to 3 years of tenure. Nurses acknowledged the importance of patient education and identified 14 barriers. Adherence to patient education showed negative correlations with age, income, educational attainment, and tenure, but positive correlations with gender, marital status, and area of assignment. Facilitating factors positively correlated with adherence, as did barriers.
Conclusions: Identifying factors affecting nurses' adherence to patient education is vital for improving these practices. Findings will support the Nursing Patient Education Development Program, enhancing patient education in Lanao del Sur's public hospitals.
Psychometric validation of the nursing professional values scale-revised: Vietnamese version
Authors: Huang Mei-Chih , Pham Thi-Phuong-Thao
Published: December 2024

Introduction: The Nursing Professional Values Scale has been widely used to assess the professional values of practicing nurses, nursing students, and faculty members across different countries. This study seeks to validate the psychometric properties of the Vietnamese version of the Nursing Professional Values Scale-Revised (NPVS-R).
Methods: A quantitative survey was conducted with the questionnaire of NPVS-R version which was converted from English to Vietnamese by three expert translators, followed by a back-translation by three bilingual experts, then three nursing scholars from different regions of Vietnam assessed the language and content validity. Data were collected from 669 nurses through the Vietnamese Nursing Association network and analyzed by using SPSS and AMOS software. The scale was evaluated based on validity of content and construct, and internal consistency.
Results: The Vietnamese NPVS-R scale comprises 25 items across four subscales: Caring, Activism, Trust, Professional, and Justice. Confirmatory factor analysis revealed factor loadings between 0.595 and 0.929, with a chi-square value of 955.303. Fit indices (CFI = 0.935, CMIN/DF = 3.605, RMSEA = 0.062) were satisfactory. Cronbach’s alpha was good, ranging from 0.861 and 0.877, and item-to-total correlations spanned 0.501 to 0.775. There exist significant differences of nurses’ perception on the subscales based on their gender, age, and working experience.
Conclusions: NPVS-R is a reliable instrument to measure the professional values of nurses in the distinct Vietnamese context and language. It can serve as a valuable tool for nursing care development and competency assessment across various care units in Vietnam and benefit international comparisons.
Association of Loneliness, Social Isolation and Health Problems in the Elderly
Authors: Dede Himawan Dwi Susanto
Published: December 2024

Introduction: Humans develop themselves and their personalities to survive and adapt to live with other humans in society as social beings. Healthy social relationships are essential for mental and physical health while disrupting social interactions can lead to loneliness and social isolation. This narrative review describes health problems in the elderly, especially depression and cardiovascular disease as a result of loneliness and social isolation. Methods: PubMed database was searched for studies written in English. Keywords to search the journals and ebooks are “loneliness”, “social isolation”, “depression”, “cardiovascular disease” and “old age”.Results: Loneliness and social isolation can occur in all age groups. It is more common in old age, where 50% of the population aged 60 years and over are at risk of experiencing social isolation and one-third experiencing loneliness. This should be of particular concern because it is a risk factor for increased morbidity and mortality in this population. This increased risk is greater than smoking, obesity, and physical inactivity. This situation is closely related to the increased incidence of depression and cardiovascular disease which are the main co-morbidities in the elderly. Conclusions: Problems of loneliness and social isolation that are not handled properly can increase the use of health services in the elderly, so special attention is needed to prevent adverse impacts on physical and mental health and reduce unnecessary use of health services.
Keywords: Loneliness, Social Isolation, Depression, Cardiovascular Disease, Old Age.
Loneliness in Bereaved Children and Adolescents
Authors: Vanessa Budiawan Soetioso  , Izzatul Fithriyah
Published: December 2024

Introduction: Bereavement in children and adolescents was a common life event, but often unrecognized. It is potentially followed by a reaction of grief. Bereavement may cause feelings of loneliness, which is associated with poor mental well-being. This study aims to understand the impact of loneliness on bereaved children and adolescents. Methods: Literature Review. Results: Childhood loss is a significant social and public health problem associated with developmental disorders — including relational, academic, and occupational functioning — as well as an increased risk of mental health problems. Loneliness occurs in childhood and adolescence is a risk factor for poorer well-being. Loneliness in children and adolescents is a risk factor for depression, social anxiety, behavioral disorders, hyperactivity, substance abuse, suicide, and premature death. Studies showed more than 50% of mental health problems develop during childhood and adolescence, with the average age being 14.5, and poorer well-being resulting from loneliness has a long-term impact on health and well-being during adulthood. Conclusions: Bereavement during childhood and adolescence period is a risk of loneliness, which is associated with a variety of mental and behavioral health problems, decreased academic performance, and impairments in developmental tasks. Early prevention and intervention are needed to reduce the risk of disorders later in life and to increase resilience among bereaved children and adolescents.
Keywords: Bereavement, Loneliness, Well-Being, Children And Adolescent
Clinical Relevance of Loneliness in Schizophrenia Patients
Authors: Windy Tiandini
Published: December 2024

Introductions: Loneliness is a subjective feeling that is described as a sense of isolation, a bad feeling about the quality and quantity of social relationships that has a major impact on mental health, well-being and quality of life. Social isolation is an important predictor of loneliness. Social isolation is often experienced by schizophrenia patients who experience alienation, social disconnection, limited access, and social support for their mental health. This study aimed to describe the relationship and its effect and factors related of loneliness and mental health, expecially in Scizophrenia patients. Methods: This study is a literature review that collects from various sources of scientific journals related to loneliness and its effect to Schizophrenia patients. Results: Lack of social interaction causes low or poor and vulnerable self-concepts experienced by schizophrenia patients, this is suspected of causing maladaptive cognition of oneself and others. Self-esteem that is seen as bad, hallucinations and delusions that are negative and self-critical reinforces negative self-concept. Schizophrenic sufferers tend to experience distortions related to self-confidence and their environment, they often think that they cannot be accepted by their environment and their environment rejects them. These increases feelings of loneliness and is thought to increase the incidence of psychotic symptoms. Conclusions: Social isolation and loneliness are important issues for schizophrenia patients because they can increase morbidity and mortality rates. Loneliness increases the incidence of auditory hallucinations with paranoid thinking, as well as negative beliefs about oneself and others in schizophrenia patients.
Keywords: Schizophrenia, Mental Health, Loneliness
Experiencing Loneliness in Motherhood
Authors: Damba Bestari  , Anish V. Cherian
Published: December 2024

Introduction: Motherhood is a lifelong learning process. Becoming a mother involves huge changes and a major shift in identity. We usually don’t pair loneliness with motherhood, but researchers have found that motherhood could be filled with lonely feelings. A study by the British Red Cross found that more than 83% of mothers under 30 years old feel lonely at some time. Even before COVID, one study found that more than 90 percent of moms reported feeling lonely after having kids, over one-third said they cried regularly, and more than half suffered from anxiety. This study aims to determine the problems with loneliness in motherhood and how they influence the whole family’s long-term growth and wellness. Methods: PubMed and Google Scholar were searched using the following keyword: (loneliness) AND (motherhood) AND (mental health) AND (maternal) using the journal publication filter for the 2018-2023 issue. Review: Loneliness isn’t only a concern for mothers but also for all family members. Mothers who experience a high degree of loneliness are likely to be depressed, which in turn leads to decreased self-esteem and poor health, and consequently the poor health of their children. Stronger involvement of the mother’s family, friends, and other support systems should be promoted. Conclusions: Researchers should pay attention to the facts that building close connections with others can stop social isolation in mothers from taking a toll on their mental health
Keywords: Loneliness, Motherhood, Mental Health, Maternal
Loneliness in College Students
Authors: Izzatul Fithriyah
Published: December 2024

Introduction: Loneliness among college students is quite prevalent. Students in their early years experience a transition period when entering university. Conditions with a new living environment, a new social environment, adjustments to peer relations, and a new academic atmosphere, support the occurrence of loneliness conditions in students. This study aims to understand loneliness in college student Methods: Literature ReviewResults: College students have a greater risk of experiencing loneliness. The impact of loneliness on students is also quite significant, both physically and psychologically. Loneliness can affect mental conditions of depression, anxiety, suicide, and low self-esteem which will ultimately lead to a decrease in quality of life. The physical effects of loneliness can also result in prolonged feelings of fatigue, limited physical activity, cardiovascular disorders, and unhealthy lifestyles which ultimately also have an impact on decreasing quality of life. Intervention and prevention to overcome loneliness are urgently needed, such as improving social skills, overcoming and adapting maladaptive social cognition, increasing social support, mindfulness interventions, and improving friendships. Conclusions: Prevention programs for loneliness are very important to implement. Such an intervention could help reduce the burden of the disease in students’ future professional lives.
Keywords: Loneliness, Well-Being, College Students
Cuproptosis-Associated Long Noncoding RNAs as Prognostic Markers in Glioma Patients
Authors: Jia Zhen , Xin Heng , Qian Zhengting , Tang Yong , Li Xiang , Shi Yan , Wu Heming , Fan Youwu
Published: December 2024

Cuproptosis, a copper-dependent cellular death mechanism, is typically overlooked in glioblastoma diagnosis. Lipoylation is needed for cuproptosis, and FDX1 controls this process. Cuproptosis in prognostic models may drive cancer treatment. This study evaluated cuproptosis and glioblastoma cell proliferation. The Cancer Genome Atlas provided annotated clinical, genetic mutation, and RNA sequencing data for the TCGA_GBM and TCGA_LGG cohorts. Patients with gliomas were randomly allocated to the validation or training cohort. Least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression models were utilized to evaluate which model best predicted prognosis in the training cohort. The models' independent predictive power was evaluated throughout the cohort. A previous study revealed 19 genes related to ferroptosis. LncRNAs associated with cuproptosis were identified by coexpression analysis. Cox discovered 17 cuproptosis-associated lncRNAs and established a predictive model. The median risk score classified patients as high- or low-risk. K‒M survival analysis demonstrated significant differences in overall survival among risk categories. Principal component analysis (PCA) and receiver operating characteristic (ROC) curve analysis were used to test the model’s predictive power. Univariate and multivariate Cox regression analyses revealed risk score-related independent prognostic factors. Multivariate Cox regression analysis was used to construct a nomogram for marker-based prognosis. The risk category affected the tumour mutation rate. High-risk glioma patients benefit from immunotherapy. Glioma drug sensitivity was also substantially linked with the risk score. The expression of 17 cuproptosis-related long noncoding RNAs (lncRNAs) may assist in the stratification of glioma patient prognosis, molecular characteristics, cell cycle gene regulation pathways, the TME, and clinicopathological aspects. Our clinical sample and database analysis revealed that cuproptosis influences glioma prognosis and may guide therapy.
Neuroprotective Effects of Functionalized Hydrophilic Carbon Clusters: Targeted 1 Therapy of Traumatic Brain Injury in an Open Blast Rat Model
Authors: Padmanabhan Parasuraman , Lu JIa , Ng Kian Chye , Srinivasan Dinesh Kumar , Sundramurthy Kumar , Nilewski Lizanne G. , Sikkema William K. A. , Tour James M. , Kent Thomas A. , Gulyás Balázs , Carlstedt-Duke Jan
Published: December 2024

Traumatic brain injury (TBI) causes multiple cerebrovascular disruptions and oxidative stress. These pathological mechanisms are often accompanied by serious impairment in cerebral blood flow autoregulation, and neuronal and glial degeneration; Background/Objectives: Multiple biochemical cascades are triggered by brain damage resulting in reactive oxygen species production alongside blood loss and hypoxia. However, most currently available early antioxidant therapies lack capacity and hence sufficient efficacy against TBI. The aim of this study was to test a novel catalytic antioxidant nanoparticle to alleviate the damage occurring in blast TBI; Methods: TBI was elicited in an open blast rat model in which the rats are exposed to the effects of an explosive blast. Key events of the post-traumatic chain in the brain parenchyma were studied using immunohistochemistry. The application of a newly developed biologically compatible, catalytic superoxide dismutase-mimetic carbon-based nanoclusters, poly-ethylene-glycol-functionalized hydrophilic carbon clusters (PEG-HCCs), was tested post-blast to modulate the components of the TBI process; Results: PEG-HCC was shown to significantly ameliorate neuronal loss in brain cortex, the dentate gyrus and hippocampus when administered shortly after the blast. There was also a significant increase in endothelial activity to repair blood-brain barrier damage as well as modulation of microglial and astrocyte activity and an increase in inducible NO synthase in the cortex; Conclusions: We have demonstrated qualitatively and quantitatively that the previously demonstrated antioxidant properties of PEG-HCC have a neuroprotective effect after traumatic brain injury following an explosive blast acting at multiple levels of the pathological chain of events elicited by the TBI.
A Testable Hypothesis on the Nature of Dark Matter Based upon Hawking’s Cosmology, A Natural Explanation for Flat Rotation Curves as Well as an Improved Prediction Algorithm for Rotation Velocities
Authors: Uffelen G.M. van
Published: December 2024

Hawking’s cosmology logically leads to an observed multiverse. This article argues it a superposition of at least three 3-dimensional universes in a 4-dimensional space, which each have two overlapping dimensions with the observed universe. For there is nothing outside it that could disturb the superposition, it could last forever. This explains why dark matter yields a linear decrease of gravity with distance to visible mass at large radii in galaxies. To prove this, all contributions of visible matter in the disks and bulges, calculated by the SPARC team, have been recalculated to verify the brightness and gas density are correctly interpreted. Lelli and Mistele showed the common way to project dark matter halos around galaxies cannot be valid. Since application of General Relativity would need these halos too, it must be modified with additional terms. Bekenstein’s TeVeS does this. Using TeVeS, a decay of the contribution of dark matter to gravity in galaxies with the expansion of space is confirmed. This explains the rapid development of large galaxies in the early universe that is reported by Labbé. A new prediction method for rotation velocities that works at all radii in galaxies is offered. It is 25% more accurate than MOND and TeVeS.
Keeping Cells Alive in Microscopy
Authors: Schneckenburger Herbert , Cremer Christoph
Published: December 2024

Light microscopy has emerged as one of the fundamental methods to analyze biological systems; novel techniques of 3D microscopy and super-resolution microscopy (SRM) with an optical resolution down to the sub-nanometer range have recently been realized. However, most of these achievements have been made with fixed specimens, i.e. direct information about the dynamics of the biosystem studied was not possible. This stimulated the development of live cell microscopy imaging approaches including Low Illumination Fluorescence Microscopy, Light Sheet Microscopy (LSM), or Structured Illumination Microscopy (SIM). Here we discuss perspectives, methods and relevant light doses of advanced fluorescence microscopy imaging to keep the cells alive at low levels of phototoxicity.
Binary Combinations of Essential Oils: Antibacterial Activity Against Staphylococcus aureus, and Antioxidant and Anti-Inflammatory Properties
Authors: Naccari Clara , Ginestra Giovanna , Micale Nicola , Palma Ernesto , Galletta Benedetta , Nostro Antonia , Cristani Mariateresa
Published: December 2024

Background: The lack of new antimicrobial drugs and the increased antimicrobial resistance has focused the attention on the employment of essential oils (EOs), particularly in veterinary medi-cine. Methods: EOs from Origanum vulgare L., Juniperus communis L., Cistus ladaniferus L., Citrus au-rantium L. var. amara were tested individually and as binary combinations to study: the in vitro antibacterial activity against Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), and Escherichia coli; the antioxidant capacity by redox-based assays (DPPH, ABTS and FRAP) and the in vitro anti-inflammatory activity by bovine serum albumin (BSA) denatura-tion inhibition assay. Results: A good antibacterial activity was observed for O. vulgare L. against all strains (MIC = 0.0312%–0.125%, v/v), followed by C. ladaniferus L. O. vulgare L. also provided the best results in terms of antioxidant and anti-inflammatory activity. Synergistic and additive effects were observed for the EO combinations, O. vulgare L./C. ladaniferus L. and O. vulgare L./J. communis L. against S. aureus and MRSA, respectively, confirmed also by the reduction of bacterial biofilm, and by antioxidant and anti-inflammatory activities. Conclusions: The results suggest that EO combinations may a be promising strategy in veterinary settings for the treatment of infectious diseases caused by S. aureus, including drug-resistant and biofilm-forming strains accompanied by oxidative stress and inflammation.
The Role of Individual Residues in the N-Terminus of Arrestin-1 in Rhodopsin Binding
Authors: Vishnivetskiy Sergey , Paul Trishita , Gurevich Eugenia , Gurevich Vsevolod
Published: December 2024

Sequences and three-dimensional structures of the four vertebrate arrestins are very similar, yet in sharp contrast to other subtypes arrestin-1 demonstrates exquisite selectivity for the active phosphorylated form of its cognate receptor, rhodopsin. The N-terminus participates in receptor binding and serves as the anchor of the C-terminus, the release of which facilitates arrestin transition into receptor-binding state. We tested the effects of substitutions of fourteen residues in the N-terminus of arrestin-1 on the binding to phosphorylated and unphosphorylated light-activated rhodopsin of wild type protein and its enhanced mutant with C-terminal deletion that demonstrates higher binding to both functional forms of rhodopsin. Profound effects of mutations identified lysine-15 as the main phosphate sensor and phenylalanine-13 as the key anchor of the C-terminus. These residues are conserved in all arrestin subtypes. Substitutions of five other residues reduced arrestin-1 selectivity, indicating that wild type residues participate in fine-tuning of arrestin- 1 binding to rhodopsin. Differential effects of numerous substitutions in wild type and an enhanced mutant arrestin-1 shows that these two proteins bind rhodopsin differently.
Contemporary Treatment of Crime Victim/Survivors: Barriers Faced by Minority Groups in Accessing and Utilizing Domestic Abuse Services
Authors: Cole Terri , Harvey Orlanda , Healy Jane , Smith Chloe
Published: December 2024

This research explored the experiences of LGBTQIA+, black and ethnic minority (BME), and disabled victims of domestic abuse due to the frequency of abuse in these populations and bespoke needs they may have. Data was collected via an online survey (n=317), a focus group with professionals (n=2), and interviews with victim/survivors of domestic abuse (n=2). Many articulated difficulties in accessing support for many reasons, including individual and structural barriers - such as embarrassment, stigma, shame, fear and not being aware of what support is available. Whilst good practice was reported, examples of secondary victimization towards victim/survivors by individuals, professionals and organizations were recounted. Many barriers were identified, for example there was inappropriate provision in refuges or shelters for LGBTQIA+ groups or disabled people. Disabled victims experienced additional barriers if their abuser was also their carer. BME groups may have additional language difficulties as well as cultural stigma and pressure to stay with their abuser. Recommendations for practice include the need for enhanced multi-agency training and recognition of abuse; crime victim/survivors being supported by someone with the same cultural background; easier access to interpreters; and more appropriate refuge or alternative housing options.
Dietary Disruptors in Romania: Seasonality, Traditions, and COVID-19 Pandemic
Authors: Pană Adrian , Strilciuc Ștefan , Ileanu Bogdan-Vasile
Published: December 2024

Background: The global rise in obesity and related comorbidities has been significantly influenced by shifts in dietary habits, exacerbated by external factors such as the COVID-19 pandemic. This study aims to analyze the trends in Romanian dietary habits from 2015 to 2023, focusing on the impact of the COVID-19 pandemic and the role of socio-economic factors, seasonality, and cultural practices. Methods: We used nationally representative data from the Romanian Household Budget Survey, which includes 30,000 households annually. The analysis is adjusted for seasonality and regional factors, ensuring a comprehensive understanding of the changes in dietary behavior. Results: During the COVID-19 pandemic, daily calorie consumption surged to over 3,000 calories per person, representing a 20% increase compared to the pre-pandemic period. Post-pandemic, food consumption remains elevated, averaging 2,500-2,600 calories per person daily. The pandemic also led to a shift in dietary composition, with a significant increase in fat and carbohydrate intake, while protein consumption decreased. Conclusions: The COVID-19 pandemic has had a lasting impact on Romanian dietary habits, reinforcing unhealthy eating patterns that were already prevalent. The sustained increase in calorie consumption, particularly of nutrient-poor, energy-dense foods, poses a significant public health challenge. The study also highlights significant seasonal variations, with a marked increase in food intake during the last quarter of the year, driven by cultural and religious traditions. These findings underscore the need for targeted public health interventions and policies that address economic factors and cultural and regional influences to promote healthier dietary behaviors in Romania.
Genetic Diversity of the Invasive Species Lissachatina fulica in the Urban Area of Cali, Colombia
Authors: Castillo Andres , Rodriguez Maria , Franco Claudia , Giraldo Alan
Published: December 2024

The African giant snail, Lissachatina fulica (family Achatinidae), is an invasive mollusk found in many countries across the Pacific, the Caribbean, Asia, and Latin America. L. fulica is known for its rapid dispersal and poses several ecosystem problems. It displaces native mollusk species and causes economic losses by damaging cultivated plants. This snail is also a public health concern as it can transmit the nematode Angiostrongylus cantonensis, leading to meningoencephalitis in humans. This study utilizes the 16S rRNA gene to examine the genetic variation of L. fulica in the city of Cali, located in southwestern Colombia. We identified two haplotypes, designated as C and D. Among the 578 samples analyzed, haplotype C was found in 11% of the samples, while haplotype D was present in 89%. Concerning demographic events in L. fulica, such as population expansions, contractions, and bottlenecks, the negative value of Tajima's D index suggests that positive selection has favored certain alleles or haplotypes, reducing genetic variation. In conclusion, the clear dominance of haplotype D in most areas might indicate that haplotype D is either more prevalent or advantageous in these environments. However, further analysis would be needed to understand the reasons for this pattern (e.g., environmental, genetic, or social factors).