bluuebunny/crossref_metadata_2025 huggingface dataset:
A Pilot Study of the Adverse Events Caused by the Combined Use of Bevacizumab and Vascular Endothelial Growth Factor Receptor-Targeted Vaccination for Patients with a Malignant Glioma
Authors: Tamura Ryota , Morimoto Yukina , Sato Mizuto , Hikichi Tetsuro , Yoshida Kazunari , Toda Masahiro
Published: September 2020

Anti-angiogenic therapy, targeting vascular endothelial growth factor (VEGF)-A/VEGF receptors (VEGFRs), is beneficial for tumor growth prevention in a malignant glioma. A simultaneous blockade using both bevacizumab (Bev), which targets circulating VEGF-A, and a multi-kinase inhibitor on VEGFRs was more effective for advanced solid cancers, including melanoma and renal cell carcinoma. However, previous clinical trials demonstrated a high adverse event rate. Additionally, no studies previously assessed treatment efficacy and safety using both VEGF-A and VEGFR-targeted agents for malignant gliomas. We had conducted clinical trials investigating VEGFRs peptide vaccination in patients with malignant gliomas, in which the treatment exhibited safety and yielded therapeutic effects in some patients. The combined use of Bev and VEGFRs vaccination may enhance the anti-tumor effect in malignant gliomas. In this pilot study, the adverse event profile in patients treated with Bev after the vaccination was investigated to establish this treatment strategy, in comparison to those treated with Bev collected from the published data or treated with the vaccination alone. In our previous clinical studies on patients with malignant gliomas, Bev was administered to 13 patients after VEGFRs vaccinations. One patient had a Grade 4 pulmonary embolism. Two patients had Grade 2 cerebral infarctions. There were no significant differences in the adverse event rates among patients treated with Bev, with the vaccination, or with Bev after the vaccination. Although careful observation is imperative for patients after this combination treatment strategy, VEGFRs-targeted vaccination may coexist with Bev for malignant gliomas.
PERBEDAAN PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS DENGAN PENDEKATAN CONTEXTUAL TEACHING AND LEARNING DI KELAS X SMA NEGERI 2 PEMATANGSIANTAR
Authors: Habeahan Winmery Lasma
Published: September 2020

The purpose of this study was to determine the differences in the improvement of students' mathematical problem-solving abilities with the Contextual Teaching and Learning approach in the material of the two-variable linear equation system in class X SMA Negeri 2 Pematangsiantar. This study used an experimental method with the aim of being in accordance with the previous statement to determine the difference in students' mathematical problem-solving abilities with a contextual approach and an expository approach, with a randomized pretest-posttest control group design. The average increase in problem-solving abilities in the control class was 0.1688 while the increase in problem-solving abilities in the experimental class was 0.0085. By using the t-test (SPSS), with a value of Fcount = 10.907 and a significant level of 0.05, a significant probability is obtained 0.002 <0.05, it can be concluded that there is a difference in normalized gain or an increase in problem-solving ability with conventional and contextual approaches. Based on the average gain of the control and experimental classes, the increase in the control class using the conventional approach is higher than the experimental class with the contextual approach. The difference in increasing problem-solving abilities in conventional classrooms is possible due to differences in students' entry-level abilities, which can be seen in the average pretest of each class.
Adult Inactivation of the Recessive Polycystic Kidney Disease Gene Causes Polycystic Liver Disease
Authors: Besse Whitney , Roosendaal Charlotte , Tuccillo Luigi , Ghosh Roy Sounak , Gallagher Anna-Rachel , Somlo Stefan
Published: September 2020

Background

A major difference between autosomal recessive polycystic kidney disease (ARPKD) and autosomal dominant polycystic kidney disease (ADPKD) lies in the pattern of inheritance, and the resultant timing and focality of cyst formation. In both diseases, cysts form in the kidney and liver as a consequence of the cellular recessive genotype of the respective disease gene, but this occurs by germline inheritance in ARPKD and somatic second hit mutations to the one normal allele in ADPKD. The fibrocystic liver phenotype in ARPKD is attributed to abnormal ductal plate formation because of the absence of PKHD1 expression during embryogenesis and organ development. The finding of polycystic liver disease in a subset of adult PKHD1 heterozygous carriers raises the question of whether somatic second hit mutations in PKHD1 in adults may also result in bile duct-derived cyst formation.

Methods

We used an adult-inducible Pkhd1 mouse model to examine whether Pkhd1 has a functional role in maintaining bile duct homeostasis after normal liver development.

Results

Inactivation of Pkhd1 beginning at 4 weeks of age resulted in a polycystic liver phenotype with minimal fibrosis at 17 weeks. Increased biliary epithelium, which lines these liver cysts, was most pronounced in female mice. We assessed genetic interaction of this phenotype with either reduced or increased copies of Pkd1, and found no significant effects on the Pkhd1 phenotype in the liver or kidney from altered Pkd1 expression.

Conclusions

Somatic adult inactivation of Pkhd1 results in a polycystic liver phenotype. Pkhd1 is a required gene in adulthood for biliary structural homeostasis independent of Pkd1. This suggests that PKHD1 heterozygous carrier patients can develop liver cysts after somatic mutations in their normal copy of PKHD1.
DA MULHER QUE DEVIEMOS ÀQUELAS QUE HÃO DE VIR: COMO RECONTAR A HISTÓRIA SUSCITA DEVIR
Authors: Sarzeda Carolina
Published: September 2020

O presente trabalho desenvolveu-se partindo de uma pesquisa monográfica a respeito do livro Calibã e a bruxa, de Federici, e a crítica que o mesmo endereça a Foucault. A partir dos três eixos do livro (mulheres, corpo e acumulação primitiva), a história das mulheres aparece em encruzilhada entre as tecnologias de disciplinamento do corpo e de acumulação de capital. Se a tese de Federici é que a história das mulheres é matricial na gênese do capitalismo, e se pretendemos desdobrar do livro estratégias políticas, chegamos aos limites da proposição: qual a relação entre história e devir para as mulheres? A questão é remontada aqui a partir de uma coincidência terminológica: o devenir femme em Beauvoir e o devenir-femme em Deleuze e Guattari. Atravessamos leituras da dupla francesa indicando que, guardadas devidas distâncias conceituais, é possível aproximar o uso que faz Federici da história a uma estratégia de desencadeamento de devires.
COREOCARTOGRAFIA FAMILIAR, LINHAS DE FUGA E...: REFLEXÕES SOBRE CRIAÇÕES EM DANÇA COMO MODOS DE DILATAÇÃO DA VIDA
Authors: Silva Juanielson Alves
Published: September 2020

O ensaio põe em pensamento aquilo que denomino de Coreocartografia familiar, visto como um procedimento estético-poético em dança, no qual o mote poético entrelaça o corpo do intérprete criador em dança em suas relações de estranhamento e familiarização com seus processos de subjetividades. Para tal, o estudo toma como suporte teórico autores como Deleuze (1998, 1995) com conceitos de linhas de fuga e cartografia e Foucault (1984) com os conceitos de cuidado de si e estética da existência, configurando deslocamentos interpretativos para os processos criadores em dança. Argumenta-se que o intérprete criador em dança é criador e criatura dos seus processos artísticos e estéticos, enfatizando o íntimo processo de singularidade no ato artísticos poéticos em dança.
INVOLUÇÃO E OS CURRÍCULOS COTIDIANOS: A EFEMERIDADE DE UMA VIDA - CORPO
Authors: Souza Letícia Regina Silva , Silva Tamili Mardegan da
Published: September 2020

Trata-se de uma pesquisa interessada nos acontecimentos produzidos por uma docência-nômade nos territórios movediços da educação e que tem como um de seus principais objetivos pensar os processos de composição-encontro dos corpos que, em meio aos movimentos curriculares, têm a involução como potencializadora da própria vida. Para tanto, defende que as práticas-políticas se realizam por meio das experiências vivenciadas cotidianamente por educadores nos mais diversos-complexos territórios do ensino público, na efemeridade de uma vida-corpo, que rompem com o instituído. Interroga, portanto, os currículos tecidos rizomaticamente, na tensão entre molar e molecular, nos quais são experimentados os diferentes modos de existência, articulados aos processos de subjetivação. Apostando na pesquisa com os cotidianos, cartografa o caráter reacionário dos fazeres docentes que compõem na defesa de que, ao (in)voluírem, os professores traçam linhas de fuga e permitem que a educação seja aerada com possibilidades outras de se pensar os currículos.
Perovskite-Enhanced Silicon-Nanocrystal Optoelectronic Synaptic Devices for the Simulation of Biased and Correlated Random-Walk Learning
Authors: Zhu Yiyue , Huang Wen , He Yifei , Yin Lei , Zhang Yiqiang , Yang Deren , Pi Xiaodong
Published: September 2020

Silicon- (Si-) based optoelectronic synaptic devices mimicking biological synaptic functionalities may be critical to the development of large-scale integrated optoelectronic artificial neural networks. As a type of important Si materials, Si nanocrystals (NCs) have been successfully employed to fabricate optoelectronic synaptic devices. In this work, organometal halide perovskite with excellent optical asborption is employed to improve the performance of optically stimulated Si-NC-based optoelectronic synaptic devices. The improvement is evidenced by the increased optical sensitivity and decreased electrical energy consumption of the devices. It is found that the current simulation of biological synaptic plasticity is essentially enabled by photogating, which is based on the heterojuction between Si NCs and organometal halide perovskite. By using the synaptic plasticity, we have simulated the well-known biased and correlated random-walk (BCRW) learning.
Sustainable Solutions for Better Public Road Transportation
Authors: Saleena Beevi S , Pradeep Kumar B
Published: September 2020

Transportation undoubtedly fastens economic growth by providing ways to initiate various modes. Population explosion, industrialization, and urbanization created more challenges to environmental stability. Urban transport is one of the essential components of urban development. Sustainable transportation includes the most efficient and convenient movement of people and vehicles with the least amount of energy, congestion, and environmental impacts. Therefore proper sustainable transport solutions are needed to pace with the developmental process. The paper attempts to provide some solutions that can ensure better human health and protection of the environment. These solutions include minimizing toxic gas emissions, electro mobility, road traffic management, congestion pricing, better parking policies, etc. These ecofriendly modes can improve the quality of public road transport and human life.
The Effectiveness of Using Language Arts in the English Language Curriculum to Teach Pronunciation and Vocabulary among Year One Students in One Semi Urban School in Malaysia
Authors: Shanmugavelu Ganesan , RK Sundaram Malar Arasi
Published: September 2020

The English Language curriculum in Malaysia is using Language Arts to teach English. Language arts is a new component designed to create appreciation and enjoyment amongst pupils as they learn the language. This fun-filled and innovative section in the new English Curriculum is a great experience and used as well as a means to create confidence in pupils to use the language without inhibitions. The focus here is the use of language arts to teach pronunciation of words and understanding the meaning of the words better among the Year One students in a semi-urban school. Therefore the research has attempted to study the effectiveness of using songs to teach pronunciation and vocabulary among these students, as compared to using the traditional method, drilling, to teach pronunciation and vocabulary.
Questioning Techniques and Teachers’ Role in the Classroom
Authors: Shanmugavelu Ganesan , Ariffin Khairi , Vadivelu Manimaran , Mahayudin Zulkufli , R K Sundaram Malar Arasi
Published: September 2020

The aim of this study is to discuss the efficacy of questioning techniques of the teachers in the classroom. Proper questioning techniques are important in the teaching and learning process. Proper questioning techniques will make it easier for teachers to get feedback from students whether or not they understand the subject. This article describes some of the questioning techniques that a teacher needs to know to possess in classroom teaching and learning sessions such as attention, suitable voice. Pause, question content, and distribution of questions. This is important for enhancing student motivation and promoting positive, critical, and creative thinking among students and to improve the teaching and learning process in the classroom.
Teaching Competencies of Upper Primary Teachers in Framing FA (a) Activities of CCE
Authors: Rajakumari C , Pazhanivelu G
Published: September 2020

The aim of the study was to find out the difference between teaching competencies of upper primary teachers in framing FA (a)activities of CCE in terms of gender, locality, marital status, residence, age, the medium of instruction, type of school, nature of school and experience. The investigator adopted a survey method on analyzing teaching competencies of 900 upper primary teachers selected Theni district using a random sampling technique. Teaching competency fivepoint rating scale consisted of 25 statements with 5 point scale developed by the researcher based on the assessment competencies (Prior instructions to activities, instructions during activities, and instructional treatment after the activities) was used to collect data. Mean, SD, ‘t’ test, and ‘F’ test were used as statistical techniques for data analysis. The findings of the study revealed thatthere was no significant difference between the teaching competency of upper primary teachers’ in framing FA (a) activities of CCE in terms of gender, locality, marital status, residence, age, and medium of instruction. Still, they differed significantly in terms of the type of school, nature of the school, and experience.
KLUSTERISASI OPTIMAL DENGAN ELBOW METHOD UNTUK PENGELOMPOKAN DATA KECELAKAAN LALU LINTAS DI KOTA SEMARANG
Authors: Ekasetya Vada Annisa , Jananto Arief
Published: September 2020

Kota Semarang merupakan kota metropolitan terbesar ke-5 se-Indonesia dengan angka kecelakaan lalu lintas yang dapat dikatakan tinggi. Dalam laporan tahunan Satlantas Kota Semarang dari tahun 2017, 2018 berurutan telah terjadi sebanyak 936 kasus dan 1.008 kasus. Kemudian pada tahun 2019 dengan hasil rekap sampai dengan bulan Agustus terjadi sebanyak 909 kasus.

Untuk mengetahui pola kecelakaan dalam mengolah data Laka Lantas dapat menggunakan sebuah metode penambangan data yang disebut data mining. Menggunakan teknik clustering dengan algoritma K-Means untuk menghasilkan pola dalam ekstraksi informasi, yang dikombinasikan dengan teknik optimasi kluster yaitu metode Elbow.

Penelitian ini menggunakan proses uji coba manual dan aplikasi RStudio. Perhitungan manual menggunakan uji coba jumlah K=2 sampai K=10 dengan penerapan metode Elbow menggunakan perhitungan nilai SSE (Sum of Square Error) pada tiap kluster. Pada grafik selisih SSE tiap kluster menunjukan patahan siku pada jumlah K=3. Perhitungan komputasi dengan aplikasi RStudio menghasilkan grafik selisih SSE dengan patahan siku pada jumlah K=3. Kemudian dengan menggunakan jumlah K=3 diimplementasikan kedalam Algoritma K-Means pada RStudio. Berdasarkan analisis yang dilakukan dengan data Laka Lantas periode bulan Oktober 2018 sampai bulan Juli 2019 menghasilkan tiga segmentasi data.
Memoria de trabajo y su relación con el rendimiento académico en estudiantes de medicina
Authors: VARELA-CERVANTES Luis Daniel , RÍOS-VALLES José Alejandro , BARRAGÁN-LEDESMA Laura Ernestina , ESTRADA-MARTINEZ Sergio
Published: September 2020

Understanding what the Working Memory is, how it works and how it is related to learning is very important for education. Objectives: To determine the relationship between working memory and the academic performance of medical students. Methodology: A cross-observational study, of a descriptive correlational type, was carried out. The design is retrospective-retrolective with a non-probabilistic sample for convenience with prior signature of informed consent with a total of 270 students of the UJED School of Medicine. Contribution: In the results obtained, no significant correlation was found between working memory and academic performance, however, a high percentage (53.3%) of students who have attended at least one subject were observed and they have better grades than the group that has not studied subjects, for that reason a second analysis was carried out by means of comparative test with U Mann-Withney, finding a significant difference between the qualifications of the groups with a p=.000, not so far the memory components of working memory which were found within normal values according to the brief neuropsychological test in Spanish.
Factors for measuring knowledge management and intellectual capital in the public sector of Jalisco
Authors: Huerta-Chávez Irma Alicia , Castro-Valencia Alberto Merced
Published: September 2020

In the public sector, stresses the importance of Knowledge Management and Intellectual Capital, as raw material in the generation and provision of services to citizens, depending on existing needs, as well as in the modernization of public administration. In this sense, the objectives of the present research are focused on identifying the necessary factors for the measurement of Knowledge Management and Intellectual Capital in the public sector of Jalisco, as well as explaining the behavior of the variables under study. For this, the scales of Rodriguez-Ponce (2007) and Chahal and Baskhi (2015) were used with six dimensions or factors, appropriate to the Mexican public context. With a cross-sectional study and a non-probabilistic sampling for convenience of 52 employees of middle managers and directors of the public sector of social assistance from Jalisco, who voluntarily accepted to participate, the results were obtained that allowed validating the instrument with necessary dimensions or factors in the explanation of the variables under study, by means of descriptive statistics and statistical tests of reliability, normality tests and correlations between elements by factor.
Graph technologies in an intelligent system of complex analysis of data from Internet sources
Authors: Piletski I. I. , Batura M. Р. , Shylin L. Y.
Published: September 2020

The purpose of the work outlined in the article is to review and demonstrate the use of graph technologies for deep data analysis. The first part of the article discusses the Intelligent System for the Comprehensive Analysis of Internet Sources Data and its possible directions for its further development. This system is a multi-purpose cluster using technologies for constructing a knowledge graph, methods and models of machine learning for in-depth analysis of data from Internet sources (for example, scientific publications, social networks, media). The purpose of the analysis is to identify the most important publications in a certain area (for example, in robotics, space research, healthcare, in the social sphere), thematic analysis of these publications, to identify the leader of a scientific direction and to predict trends in the development of directions and interaction of groups of people. When developing this system, we utilized probabilistic machine learning algorithms and methods for constructing and maintaining a graph model of the social network of authors and their publications, determining the rating of a particular author, determining the topics of publications and classifying them by areas of knowledge. The basis for the creation of intelligent applications is graph technology, which allows you to make predictions that are more accurate. The combined application of methods and algorithms of machine learning with graph technologies allows you to get hidden dependencies and perform predictive analysis of information, get answers in real time, and implement artificial intelligence algorithms. Methods of collaboration with graph technologies and a learning machine (for example, using neural networks) are based on graph embedding. This technology allows you to perform a comprehensive, deep and intelligent analysis of information. At the end of the article, there are analytical reports obtained using graph technologies in the Intelligent System for Complex Analysis of Internet Sources Data.
ETHNIC IDENTITY: VIEWS OF RESIDENTS OF A LARGE CITY ON RUSSIAN ETHNOS
Authors: Merenkov A.V. , Scriabina K.Yu. , Antonova N.L.
Published: September 2020

On the basis of a sociological study, the article considers the views of the population of a large industrial city on ethnic identity. The survey was conducted in 2019 in the city of Yekaterinburg. The methods of collecting information were online survey (n = 259) and in-depth interviews (n = 16). The results of the study indicate that the concept of Russians (as an ethnic group), both among foreign ethnic groups and among citizens who attribute themselves to Russians, is determined on the basis of cultural and historical facts. According to the respondents, the main characteristics defining the “Russian character” are openness, friendliness, hospitality, kindness, simplicity, and straightforwardness. Interviewees who identify themselves as belonging to the Russian people form a positive image of the Russian person, and representatives of other ethnic groups note ethnic traits such as sullenness, severity, unfriendliness, selfishness. Ethnic identity is actualized in a foreign language environment and contributes to the affirmation of belonging to Russian culture, primarily through the preservation of the Russian language, as well as the reproduction of everyday practices and event actions that demonstrate differences from other ethnic communities and involvement in Russians as an ethno-national education.
IDEOLOGY OF CIVILIZATIONAL SOVEREIGNTY OF RUSSIA (IN THE CONTEXT OF RUSSIA-WEST RELATIONS)
Authors: Darenskiy V.Yu.
Published: September 2020

This article examines the objective prerequisites for the formation of the ideology of civilizational sovereignty of Russia (ideology of mobilization type) in the context of Russia - West relations. Currently, the carrier of ideology is not the state (it is prohibited by the Constitution of the Russian Federation), but civil society - and the ideology is not so much political as civilizational (spiritual and cultural), providing mental, cultural and moral unity of society. However, in this capacity, ideology still performs its classical political function of ensuring the political and ideological mobilization of people in the form of their political consciousness development. Modern Russian society can effectively develop any new social institutions and forms of social activity necessary for the development of modern man-made civilization, but the intellectual and moral degradation of people, which has been going on for several decades as a consequence of the development of “consumer society”, destroys the human resource of Russia in qualitative terms. Only the model of “mobilization society”, which is a legacy of traditional civilization, can resist this. In modern conditions, ideology cannot be, as it was in the era of classical ideologies, a set of unified theses and definitions. The modern non-classical “mobilization ideology” of the Russian civil society is not a set of initially defined concepts, but a set of basic values that can be interpreted individually, based on different worldview positions. Only in this case the ideological consolidation of society is possible, otherwise the described state of ideological chaos will remain insurmountable.
PIJAT REFLEKSI BERPENGARUH TERHADAP TEKANAN DARAH PADA PASIEN HIPERTENSI DI KLINIK ATGF 8 PALEMBANG
Authors: Lukman Lukman , Putra Sumitro Adi , Habiburrahma Elba , Wicaturatmashudi Sukma , Sulistini Rumentalia , Agustin Ismar
Published: September 2020

Latar belakang: Hipertensi sering disebut sebagai pembunuh yang tidak diketahui, karena penderita tidak tahu bahwa dirinya menderita hipertensi. Banyak macam terapi komplementer yang dapat diterapkan untuk mengobati hipertensi, salah satunya pijat refleksi.

Metode: Penelitian ini bertujuan untuk mengetahui pengaruh pijat refleksi terhadap tekanan darah pada pasien hipertensi di Klinik ATFG-8 Palembang. Desain yang digunakan pada penelitian ini adalah pra-eksperimen dengan menggunakan rancangan one group pre-test post-test. Sampel pada penelitian ini adalah keseluruhan pasien hipertensi yang tidak mengkonsumsi obat penurun tekanan darah dan berkunjung untuk melakukan terapi pijat refleksi pada bulan 17 April s.d 17 Mei 2018. Penentuan sampel dengan metode purposive sampling sebanyak 18 subjek penelitian.

Hasil: Hasil yang diperoleh adalah rata-rata usia sampel 54,22 tahun (± 7,216), tekanan darah sistolik sebelum 148,44 mmHg (± 4,527) dan setelah pijat refleksi 143,78 mmHg (±  8,633). Hasil paired sample T test  menunjukkan efek pijat refleksi pada tekanan darah sistolik (p = 0,026) dan diastolik (p = 0,001)

Kesimpulan: Terjadi penurunan tekanan darah secara statistik, namun secara substansi tidak bermakna. Peneliti berikutnya diharapkan untuk melakukan penelitian lebih lanjut dengan menambahkan sampel dan menggunakan kelompok kontrol.
基于旅游动机和重游意愿之间的认知结构关系研究———以中福建湄洲妈祖文化旅游为例
Authors: 胡 思炜
Published: September 2020

现如今，中国旅游业正处于飞速发展阶段，妈祖文化旅游也是中国宗教旅游的代表。论文以中国游客为研究对象，通过查阅妈祖文化和宗教旅游的相关文献, 采用问卷调查法并结合应用 SPSS 软件进行分析，揭示了游客到中国福建湄洲妈祖庙的旅游动机和重游意愿之间的认知结构关系。结果显示，宗教旅游胜地的氛围与设施对游客感知价值有着不同程度的影响，不同的旅游动机对重游意愿影响效果不同。最后，希望通过研究可以为促进中国妈祖文化旅游的发展提供建议。
赤峰民营经济高质量发展研究
Authors: 赵 娜
Published: September 2020

随着中国国民经济发展迈入新时代，民营经济作为中国社会主义市场经济的重要组成部分，也迎来了新的挑战和转型。本文通过分析民营经济在发展过程中普遍存在的问题，探究了推动民营经济发展的相关措施及对策，从而促进赤峰地区民营经济的高质量发展，为实现赤峰经济的可持续发展创造条件。
会计信息系统对商业银行会计管理的影响分析
Authors: 池 军
Published: September 2020

论文就会计信息系统对商业银行会计管理的影响进行了探讨，从阐述会计信息系统对商业银行财务管理的正面影响和负面影响入手，进一步提出针对会计信息系统缺陷的改善对策与未来发展建议。
中国军队停偿资产委托经营模式探讨
Authors: 李 国兴
Published: September 2020

停止中国武警部队和军队的有偿服务，探索停偿资产委托经营模式是中国着眼于新时代的强军目标，实现全面建成世界一流军队作出的重大决策部署，同时也是深化中国军队改革的重要内容。当前，停止有偿服务工作开展处于关键时期，论文针对停偿资产委托经营模式进行探讨并希望经过各级共同努力，取得更加明显的成效。
后疫情时代金融开放促进中国经济高质量发展问题研究
Authors: 杨 从会 , 蒋 雨潇 , 杨 荣宗 , 但 佳丽 , 张 春连
Published: September 2020

随着新冠肺炎跨国传递范围和程度的加深，疫情可能会打破全球经济的脆弱平衡，如今疫情已经覆盖全球价值链的重要节点，尤其是经济全球化以来全球的供应链垂直一体化不断发展，欧美地区已经陆续出台停止除必需品以外一切经济活动的严格防疫措施。而如今中国在全球价值链中扮演的角色日益重要，在面临全球经济不景气的大环境下也难置身事外。因此，论文着重分析疫情对全球及中国经济的影响，并从金融开放视角提出相应的解决办法，以新思维引领新实践新发展，为后疫情时代中国经济高质量发展提供源源不断的活力。
上市公司财务报表粉饰问题研究———以 JR 公司为例
Authors: 万 准
Published: September 2020

随着资本市场的不断发展，财务报表粉饰问题一直饱受诟病，尤其在上司公司。根据《公司法》的相关规定，对于连续两年经营业绩都是亏损的上市公司，将会被冠以 ST称号，而对于连续三年都出现亏损的上市公司，将会暂停上市。因此，一些上市公司为了保持其上市公司的资格，就会对财务报表加以粉饰。论文以 JR 公司为例，研究该公司是通过哪些手段来粉饰财务报表的。
NSM 规则与船舶生态环境及体系文化传播的思考
Authors: 汪 劲松
Published: September 2020

目前，中国的船舶生态环境还存在一些问题，而 NSM 规则的有序进行能够保证船舶生态环境的安全，论文通过对当前船舶安全的生态环境的分析并探究了如何确保NSM 规则有序进行以及体系文化传播。
新冠疫情下 ESG 因素对 A 股上市公司的影响
Authors: 陈 周永
Published: September 2020

新冠疫情给 A 股市场带来了很大的冲击，论文通过探讨不同 ESG 评级的上市公司在疫情期间的表现得出：在疫情期间，相对于 ESG 表现较差的上市公司，ESG 表现好的上市公司呈现出较高的收益率和稳健的风险水平。最后，就 ESG 在中国的发展提出了建设性的建议。
钢板桩支护技术在房屋建筑工程中的应用
Authors: 刘 耀琦 , 刁 永华 , 蒋 志恒
Published: September 2020

论文针对深基坑工程，在了解钢板桩基坑支护意义基础上，详细介绍了钢板桩基坑支护技术的应用和实施要点，为钢板桩支护工程的应用提供借鉴。
土木工程混凝土建筑加固技术研究
Authors: 徐 增淼
Published: September 2020

混凝土建筑结构在使用过程中会老化，需要建设单位采用相应的加固技术进行加固。论文提出了混凝土建筑加固设计的一般原则，并根据这一原则分析了外包钢加固法、外部黏钢加固法和黏贴碳纤维加固法三种不同加固方法的使用要求、承载力计算方法和特点，希望能够为混凝土建筑工程项目提供理论指导。
深水钢栈桥设计和施工技术
Authors: 庞 雷
Published: September 2020

钢栈桥属于结构性临时设施，为人员作业、物料及设备运输提供了平台。论文结合福建永梅出省公路石杰大桥钢栈桥的施工经验，对深水钢栈桥的设计及施工技术进行研究分析，并总结经验，希望能提供一定参考价值。
预应力施工技术在道路桥梁施工技术中的应用研究
Authors: 王 先峰 , 魏 香丽
Published: September 2020

在道路桥梁施工中，预应力施工技术具有十分重要的作用，将其运用在道路桥梁的施工中，能有效地解决道路桥梁工程施工中存在的各种应力问题，从而从整体上提升道路桥梁的性能。论文简单阐述了预应力施工技术及其在道路桥梁施工技术中应用的重要作用，并在此基础上分析了预应力施工技术在道路桥梁施工技术中的具体应用及应注意的问题。
铁路客车空调机组压力故障问题研究
Authors: 赵 儒家 , 陈 全雷 , 于 云龙
Published: September 2020

论文阐述了铁路客车空调机组制冷系统中压力控制器的作用及保护原理，分析了发生压力保护动作的各种可能原因及相应的判定方法，并针对各项原因制定了可行性较高的解决措施。
铅锌选矿重金属废水处理技术研究
Authors: 王 静怡 , 覃 勇
Published: September 2020

论文首先分析了铅锌选矿重金属废水的来源，其次对其所产生的危害进行了阐述，最后对国际现有的铅锌选矿重金属废水处理技术进行了研究，以此提高铅锌选矿重金属废水处理的效果，以供相关人士参考。
基于信息技术的重庆水质预警预报系统研究
Authors: 张 俊
Published: September 2020

当前，水质监测监管业务缺乏快速有效的预报预警手段，缺少全面精准的辅助决策及依据，未应用数值对整个流域系统及其内部发生的复杂污染过程进行的定量化描述。论文通过研究水质监测监管业务流程及开展情况，将信息技术应用到水质预警预报中，阐述了核心模型搭建技术路线，对数据库构建及应用建设进行了分析。
刍议加强水利水电工程施工管理
Authors: 东 智锋
Published: September 2020

随着中国经济社会的快速发展，对水利水电工程的建设和管理呈现出越来越重要的趋势。因此，在实际的工作之中，进行相应的管理方法改进，推动水利水电工程质量的提升成为各方关注的问题。论文从水利水电工程施工的具体特点和影响施工管理的因素入手，探讨了工程质量管理、安全管理和进度管理方面的措施，以期对实际的工作有所帮助。
Plaxis 在深基坑开挖过程中的数值模拟和应用
Authors: 王 健 , 黄 晓冀 , 陈 晨 , 杨 明
Published: September 2020

岩土工程有限元分析软件 PLAXIS 2D 目前已经被广泛地应用于深基坑开挖工程的数值模拟中。论文使用 PLAXIS 2D 对地下连续墙支护下的基坑开挖的施工全过程进行了数值模拟，得出了基坑开挖过程对支护结构及其周边土体的影响，为今后同类问题的研究积累了经验。
研究心血管内科护理中的风险因素以及相关安全防范措施
Authors: 王 丹丹
Published: September 2020

目的：研究心血管内科护理中的风险因素以及相关安全防范措施。方法：分析护理中的危险因素，并制订相应的护理方法。结果：干预组患者的护理满意度相对较高，不良事件的发生率较少。结论：有效提高患者的护理满意度，降低不良事件的发生率。
宫腔镜微创手术在妇产科中的应用进展
Authors: 张 慧 , 陈 丹丹 , 邹 洁宁
Published: September 2020

宫腔镜可以直接观察子宫和宫腔病变，凭借其创伤小、并发症少、安全、康复快等特点在妇产科病症治疗中显现出独特优势。近年来，在无创技术、宫腔镜设备及器械和机器人辅助宫腔镜手术等方面的创新更是加速了宫腔镜微创手术的发展。论文讨论了宫腔镜微创手术相关技术的新进展，并分析了宫腔镜微创手术技术的发展前景。
老年高血压患者自我管理研究进展
Authors: 王 晨
Published: September 2020

论文主要对老年高血压患者自我管理研究进展进行分析，希望能够帮助患者控制疾病，提高高血压疾病的临床治疗效果。
滴眼液中防腐剂使用的利弊及应对措施
Authors: 王 明翠 , 刘 洋
Published: September 2020

目的：考察滴眼液中防腐剂的使用情况，探讨使用防腐剂的利弊，不同种类防腐剂对正常机体细胞的伤害，如何最大限度地控制防腐剂的使用，达到既不影响疗效，又不造成伤害的预期效果。方法：通过考察多剂量包装滴眼液开封后室温放置不同时间微生物污染情况，分析滴眼液添加防腐剂的必要性。进一步通过考察不同防腐剂对正常细胞的伤害，正视防腐剂的危害。并通过将防腐剂与保护剂同时作用于细胞进行试验，考察细胞存亡情况。结果：不同防腐剂对细胞有不同程度的伤害，随着时间的增加，伤害程度加重，保护剂有一定的缓解作用。结论：多剂量滴眼液需要添加防腐剂，可以适当添加保护剂，减轻伤害，如果条件允许，推荐开发单剂量包装产品。
The Programmable Data Plane: Abstractions, Architectures, Algorithms, and Applications
Authors: Michel Oliver , Bifulco Roberto , Rétvári Gábor , Schmid Stefan
Published: September 2020

Programmable data plane technology enables the systematic reconfiguration of the low-level processing steps applied to network packets and is a key driver in realizing the next generation of network services and applications. This survey presents recent trends and issues in the design and implementation of programmable network devices, focusing on prominent architectures, abstractions, algorithms, and applications proposed, debated, and realized over the past years. We elaborate on the trends that led to the emergence of this technology and highlight the most important pointers from the literature, casting different taxonomies for the field and identifying avenues for future research.
Design and Expansion Planning of Parallel Inverter Based AC Microgrids - An Approach for Improved Stability Margins
Authors: Firdaus Ayesha , Molinas Marta
Published: September 2020

This paper presents an application of impedancebased modelling approach to identify suitable locations for design

and expansion planning of an inverter based autonomous AC microgrid. The objective is to find out ideal location for placement of additional components which can include new inverter-based sources, microgrid damping controller, etc., ensuring sufficient stability margins. These objectives are achieved by first identifying the weakest and the strongest nodes in the system with respect to the system stability and then observing the effects of choosing various nodes for design and expansion on overall system stability. The weakest and the strongest nodes are identified
using the impedance based stability analysis of the microgrid by dividing the system in various possible partition points while the impact of choosing different locations on stability is analyzed by eigen value analysis as well as time-domain MATLAB/Simulink simulations and experimental results.

This paper has been submitted to JESTPE on 25-04-2020 and rejected on 29-08-2020.
Reduksiepotensiaal van b-diketone: Die effek van elektronskenkende, aromatiese en estersubstituentgroepe
Authors: Conradie J , Mateyise NGS , Conradie MM
Published: September 2020

’n Elektrochemiese en berekeningschemiese studie van geselekteerde β-diketone word aangebied. Die effek van elektronskenkende, aromatiese en estergroepe op die 1 en 3 posisie van die β-diketone op die reduksiepotensiaal van β-diketone word geïllustreer en bespreek. ’n Analise van die digtheidfunksionaalteorie-berekende (DFT-berekende) spin digtheidsprofi el en molekulêre elektrostatiese potensiaal van die gereduseerde β-diketone gee insig in die elektronverspreiding in die gereduseerde molekule. Daar is bevind dat die digtheidfunksionaalteorie-berekende (DFT-berekende) laagste ongevulde molekulêre orbitaal energieë (ELOMO) van die β-diketoon lineêr verband hou met die eksperimentele reduksiepotensiaal. Hierdie resultaat kan gebruik word om die verwagte eksperimentele reduksiepotensiaal van nuut-ontwerpte β-diketone te bepaal.
Identifikasie en beskrywing van ’n onbekende Spinitectus sp. van Clarias gariepinus ingesamel in die Vaaldam, Suid-Afrika
Authors: Austin L , Dos Santos QM , Avenant-Oldewage A
Published: September 2020

Spinitectus is ’n genus van parasitiese nematode wat aan die familie Rhabdochonidae behoort, wat gekenmerk word deur die teenwoordigheid van ringe skerp stekels wat posteriorwaarts in grootte verklein. Tydens standaard parasitologiese ondersoeke in die Vaaldam, Suid-Afrika (Maart 2018), is agt Spinitectus-wurms ingesamel van Clarias gariepinus. Slegs twee spesies is in Suid-Afrika bekend en albei is in die Kruger Nasionale Park ingesamel: Spinitectus petterae (Krokodilrivier) van C. gariepinus en Spinitectus polli (Sabierivier) van Synodontis zambezensis. Die genus is nog nie tevore in die Vaalrivier aangeteken nie. Die doel van hierdie studie is om die morfologie, morfometrie en molekulêre kenmerke van die wurms wat in die Vaalrivier ingesamel is met die ander Afrika-spesies te vergelyk en hulle identiteit te bepaal. Met behulp van ligmikroskopie is die wurms met anhidriese gliserol opgehelder, bestudeer en daarna met ander Afrika-spesies vergelyk. Verskille tussen die skerp stekels en lengteverhoudings van strukture is vir die vergelykings gebruik. Een wurm is met behulp van skandeerelektronmikroskopie met heksametieldisilasaan (HMDS) gedroog om sy eksterne morfologie te bestudeer. Onderskeidende strukture wat opgemerk is, was die kefaliese en kaudale papille, die vorm van die pseudolabia en die plasing van die stekelringe. Die klein ribosomale subeenheid (18S) van rDNS is gebruik om die identiteit van die wurms te bepaal.
Die ingesamelde spesie was geneties die naaste verwant aan S. petterae, maar die assosiasie is swak ondersteun en hulle kon geneties onderskei word. Uitsteeksels teenwoordig op die wyfies was soortgelyk aan S. polli en S. petterae. Die lengtes van die wurm voor die vulva teenoor die lengte na die anus was soortgelyk aan Spinitectus maleficius, Spinitectus allaeri en S. petterae. Die spikulum-grootte was soortgelyk aan S. petterae, S. polli en Spinitectus minusculus. Weens ’n beperkte verband tussen die genetiese en morfologiese resultate van die ingesamelde wurms van die Vaaldam en Spinitectus-spesies wat in ander gebiede in Afrika ingesamel is, is meer inligting derhalwe nodig om hierdie nematode akkuraat te identifiseer of moontlik as ’n nuwe spesie te beskryf.
PENDEKATAN DESAIN SISTEM SOSIAL-TEKNIS UNTUK MENDUKUNG KOMPETENSI LULUSAN DI JAWA BARAT
Authors: Gustiana Iyan , Hasti Novrini , Wahyuni W , Sanjoyo D D , Mubaroq S R
Published: September 2020

Tujuan dari penelitian ini adalah merancang sistem sosial-teknis sebagai solusi untuk mengatasi pengangguran terbuka di Jawa Barat, yaitu lulusan sarjana. Peningkatan jumlah pengangguran terbuka tingkat universitas (lulusan TI) cenderung meningkat setiap tahun. Salah satu alasannya adalah bahwa kompetensi lulusan tidak sesuai dengan yang dibutuhkan oleh bisnis dan industri. Maka, perlu untuk membuat desain yang bisa mengatasi hal ini. Penelitian ini menggunakan metode analisis Triple Helix dan sistem sosial-teknis. Langkah analitik yang diambil dalam penelitian ini adalah observasi dokumenter dan pengolahan data statistik. Hasil penelitian ini diusulkan desain teknis dan desain implementasi sebagai bentuk kolaborasi dari universitas dan industri yang dibantu oleh pemerintah sebagai regulator. Desain ini dapat digunakan oleh universitas, untuk meningkatkan kurikulum dan penelitian. Harapan dari desain ini dapat memperbarui dan meningkatkan kebutuhan bisnis dan industri dan memiliki lulusan yang kompetenKata Kunci : Sosial-teknis, Pengangguran, Lulusan sarjana
EFEKTIVITAS PIJAT BAYI TERHADAP PENINGKATAN KUALITAS TIDUR BAYI
Authors: Sukmawati Ellyzabeth , Nur Imanah Norif Didik
Published: September 2020

Tidur merupakan salah satu faktor yang mempengaruhi pertumbuhan bayi. Peningkatan kualitas tidur bayi dapat dilakukan melalui pijatan yang dilakukan orang tua. Tujuan penelitian ini adalah untuk mengetahui efektivitas pijat bayi terhadap peningkatan kualitas tidur bayi. Metode penelitian yang digunakan dalam penelitian ini adalah pre eksperimental dengan pendekatan pretest posttest one group design. Penelitian ini dilakukan di bidan praktik mandiri Emy Winarni Kesugihan Cilacap. Dalam penelitian ini yang menjadi populasi adalah ibu bayi   yang berjumlah 30 bayi dengan menggunakan teknik sampling total population. Hasil penelitian ini adalah Terdapat efektivitas pijat bayi terhadap peningkatan kualitas tidur bayi   dibuktikan dengan responden yang mengalami peningkatan kualitas tidur  sebagian besar (73,33%) responden mempunyai kualitas tidur yang baik..
ОПРЕДЕЛЕНИЕ УСЛОВИЙ ВЫСОКОПРОИЗВОДИТЕЛЬНОГО НИЗКОТЕМПЕРАТУРНОГО ШЛИФОВАНИЯ
Authors: Новиков Ф. В., д. т. н.
Published: September 2020

Аналитически установлено, что при шлифовании реализовать условие стабилизации температуры резания, обеспечивающее одновременно увеличение производительности обработки, можно применением прогрессивного метода глубинного шлифования с относительно небольшой скоростью детали и глубиной шлифования более 5 мм. В этом случае с увеличением глубины шлифования или скорости детали (в определенных пределах) температура резания остается постоянной, а производительность обработки увеличивается. Это подтверждается результатами экспериментальных исследований. На этой основе обоснованы условия уменьшения температуры резания при одновременном существенном увеличении производительности обработки и даны практические рекомендации по выбору рациональных параметров шлифования по температурному критерию. Показано, что при лезвийной обработке при определенных условиях можно в широких пределах увеличивать производительность обработки фактически без увеличения температуры резания, что согласуется с экспериментальными данными. Это связано с уменьшением доли тепла, уходящего в поверхностный слой обрабатываемой детали.
ВПЛИВ ОКРЕМИХ КОНСТРУКТИВНИХ ПАРАМЕТРІВ ПРИВОДУ ІЗ ПНЕВМОМЕХАНІЧНОЮ СИСТЕМОЮ ПОВІТРОРОЗПОДІЛУ НА РОБОЧІ ХАРАКТЕРИСТИКИ ВІБРОУДАРНИХ МАШИН
Authors: Стасюк В.М., к.т.н.  , Андрощук І.В., к.с.-г.н.
Published: September 2020

Завдання вибору оптимальних конструктивних параметрів приводів для забезпечення потрібних робочих характеристик віброударних пневматичних машин завжди актуальне, у тому числі й пневматичних приводів, системи повітророзподілу яких оснащені клапанними повітророзподільниками.
У статті наведені результати досліджень впливу окремих конструктивних параметрів приводу із пневмомеханічним розподілом стисненого повітря на робочі характеристики віброударних машин. В якості окремих конструктивних параметрів приводу вибрано: діаметри робочих вікон впускних елементів камер холостого та робочого ходів, діаметри випускних отворів і відстань між осями впускних елементів камери холостого ходу та випускними отворами. При цьому для вибору більш досконалої конструкції приводу розглядалися три його конструкції: із регульованим дроселем у кришці компенсаційної камери холостого ходу, із регульованим дроселем у кришці компенсаційної камери робочого ходу та без регульованих дроселів у кришках вищезазначених камер. В якості робочих характеристик віброударної машини вибрані: енергія удару, частота ударів, хід поршня-ударника та тривалість циклу.
Отримані результати досліджень дозволяють вибирати оптимальні величини конструктивних параметрів приводу із пневмомеханічною системою повітророзподілу для забезпечення потрібних робочих характеристик віброударної машини.
УДОСКОНАЛЕНИЙ МЕТОД ЕЛАСТОГРАФІЇ КРОВОНОСНИХ СУДИН
Authors: Витвицька Л.А.  , Лаврук Х.З.  , Чуйко М.М.  , Витвицький З.Я.
Published: September 2020

Проведено аналіз існуючих методів ультразвукового контролю людського організму. Обґрунтовано доцільність проведення еластографії сонних артерій з метою діагностики атеросклерозу і ступеня нерухомості атеросклеротичних бляшок у судинах. Теоретично обґрунтовано доцільність проведення еластографії з використанням зсувних хвиль, які виникають  при  застосуванні радіаційного тиску сильного сфокусованого ультразвукового імпульсу. Розроблено конструкцію електронного ультразвукового сканера, який забезпечує високу чутливість прийнятих сигналів на різних глибинах з високою роздільною здатністю. Визначено параметри ультразвукових датчиків, розроблена методика проведення дослідження, яка забезпечує проведення контролю на різних глибинах, показано приклад проведення еластографії сонних артерій.
МОДЕЛЮВАННЯ ВПЛИВУ ТЕПЛОТИ ЗГОРЯННЯ ПРИРОДНОГО ГАЗУ НА ВИМІРЮВАННЯ ЙОГО ВИТРАТИ ТОРЦЕВИМИ СОПЛАМИ
Authors: Малісевич Н.  , Середюк О.Є.,
Published: September 2020

Анотація. Проведено аналіз відомих нормативних документів і технічних рішень для визначення теплоти згоряння природного газу. Охарактеризовано патентозахищений метод і алгоритм контролю теплоти згоряння, який базується на вимірювання температури спалювання газу за умови вимірювання витрати природного газу за допомогою спеціальних звужувальних пристроїв – торцевих сопел. З використанням комп’ютерного моделювання досліджено взаємозв’язок фізичних характеристик і компонентного складу природного газу з його теплотою згоряння за умови вимірювання витрати газу торцевими соплами. Отримані алгоритмічні залежності між теплотою згоряння природного газу і його коефіцієнтом стисливості, який визначається впливом густини газу і вмісту негорючих компонентів. Кількісно оцінено вплив зміни густини природного газу на коефіцієнт стисливості і теплоту згоряння газу порівняно із зміною вмісту азоту і вуглекислого газу. Досліджено вплив густини газу і вмісту азоту на показник адіабати і коефіцієнт розширення газу при вимірюванні витрати торцевим соплом пальника. Результати моделювання дозволили запропонувати ітераційно-експериментальний метод розрахунку теплоти згоряння природного газу при його експериментальному визначенню без безпосереднього вимірювання густини газу.
Evidence of Abnormally Low Lymphocyte-To-Monocyte Ratio In COVID-19-Induced Severe Acute Respiratory Syndrome
Authors: Lissoni Paolo
Published: September 2020

It is known that lung injury due to COVID-19 responsible for the respiratory distress would mainly depend on host inflammatory response, depending on the excessive production of inflammatory cytokines, such as IL-6, and TNF-alpha, rather than direct virus-induced tissue damage, as well as for other forms of respiratory distress. Moreover, it is known that the inflammatory cytokines may induce profound changes in the behavior of the hematic cells, namely neutrophils, monocytes, and lymphocytes, with a following enhanced tissue infiltration by their inflammatory cells. According to the data available up to now, IL-6 and TNF-alpha would be the main cytokines involved in determining COVID-19-induced lung injury, as well as in other coronavirus infections, and most in general in all conditions of respiratory distress. Since it is known that the functionlessness of the whole immune system is namely depending on the interactions between lymphocyte and macrophage system, a preliminary study was planned to analyze the lymphocyte-to-monocyte ratio (LMR) in COVID-19 infective disease. The study included 17 consecutive patients, who underwent ventilator therapy for COVID-19-induced respiratory distress, and 100 healthy subjects, as a control group. Lymphocytopenia and monocytosis occurred in 14/17 (82%) and in 8/17(47%), respectively. Then, abnormally low values of LMR was found in 12/17 (71%) patients, and LMR men values observed in patients were significantly lower than in control (P<0.001). Therefore, by reflecting the interactions between lymphocyte and monocyte-macrophage systems, LMR could constitute a simple and less expensive biomarker to monitor the clinical evolution of COVID-19 infection.
Warm Compress Of Pain Level In Patients Elderly Who Suffers Rematic
Authors: Firdaningsih  , Amirullah  , Amin A.Nurlaela
Published: September 2020

The background based on data found at the society health center of  Bontonyeleng, district of Gantarang, the regency of Bulukumba.it received 45 rheumatic patients in 2017. The aim of this research is to find out the influence of warm compress to decrease the pain degree of rheumatic patients qat society health center of Bontonyeleng, district of Gantarang, the regency of Bulukumba. The method has taken in this research was experimental research ( pre-experimental design) using the one-group pretest-posttest design. The population sample in this research was 30 respondent, it was taken using shack formula. Data analyse result using T-test match with value p 0,000. the research result gained before applying warm compress ton lo pain degree patients are 2 respondents or (6.7%)  medium paint degree patient is 28 respondents or (93,3). While the result after applying a warm compress for low pain degree patients is 20 respondents or (66.7%) medium pain degree patient is 10 respondents or  (33.3%). Based on explanations above, we can conclude that there is the influence of warm compress to decrease pain degree for the rheumatic patient especially for old society at society heald center of Bontonyeleng, district of Gantarang, the regency of Bulukumba so that is why people in bukit harapan village, district of Gantarang, regency of Bulukumba suggests for those who feel the pain that indicates rheumatic should not ignore and do an action like applying warm compress immediately using correct tools to decrease the pain or doing health check as soon as possible to nearby medical care.
Synthesis of 6,13-difluoropentacene
Authors: Tripp Matthias W , Koert Ulrich
Published: September 2020

6,13-Difluoropentacene was synthesized from 1,4-difluorobenzene. Friedel–Crafts annulation of the latter with phthalic anhydride and subsequent reduction of the anthraquinone gave 1,4-difluoroanthracene. After ortho-lithiation and reaction with phthalic anhydride a carboxylic acid was obtained whose Friedel–Crafts acylation and subsequent reductive removal of the oxygen-functionalities resulted in the formation of the target compound. The HOMO–LUMO gap of 6,13-difluoropentacene was determined via UV–vis spectroscopy and compared to other fluorinated pentacenes.