bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Ukuran Kantor Akuntan Publik, Opini Audit, Pergantian Manajemen, Dan Financial Distress Pada Auditor Switching
Authors: Silitonga Mark Raymond , Hutapea Joan Yuliana
Published: April 2024

Perusahaan publik yang telah mencatatkan sahamnya di Bursa Efek Indonesia (BEI) wajib mengumumkan laporan keuangannya kepada publik dan telah mengaudit laporan keuangannya. Oleh karena itu, seorang auditor harus menjaga kualitas audit keuangannya. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh Ukuran KAP, Opini Audit, Perubahan Manajemen dan Financial distress terhadap Auditor Switching. Metode penelitian ini menggunakan metode kuantitatif dengan menggunakan purposive sampling sebagai penentuan sampel. Hasil penelitian ini menunjukkan bahwa opini audit berpengaruh terhadap Auditor Switching sedangkan variabel independen lainnya seperti ukuran KAP, perubahan manajemen, dan financial distress tidak berpengaruh terhadap Auditor Switching.
Perancangan Komunikasi Visual Promosi Inovasi Produk Kuliner Malbi Khas Kota Palembang
Authors: Okta Wahdjudha Rizkha , Yulius Yosef , Iswandi Heri
Published: April 2024

Palembang merupakan salah satu kota yang memiliki banyak sejarah budaya dan kuliner tradisionalnya. Kuliner tradisional Indonesia adalah kuliner atau makanan khas dari suatu daerah yang telah ada sejak dahulu dengan bahan-bahan dan rempah asli dari Indonesia. Kuliner Malbi adalah salah satu kuliner khas dari Kota Palembang yang sudah ada sejak kerajaan dan kesultanan Palembang. Dahulu Kuliner Malbi di sajikan dan dimakan bersama-sama oleh para kesultanan dan suku elit Arab dan India sesudah menunaikan Shalat Jumat bersama. Kajian utama pada penelitian ini dititikan pada identifikasi, analisis dan perancangan pada karya desain produk Mie CupInstan dengan rasa Kuliner Malbi, video B-roll Cinematic dan media pendukung lainnya. Pada perancangan Promosi ini menggunakan metode perancangan main media, pre-media, dan lainnya. Data tersebut kemudian diindentifikasi dan dianalisis menggunakan metode Design Thinking yang diintepretasikan sesuai teks dan konteksnya. Perancangan Komunikasi Visual Promosi Inovasi Produk Kuliner Malbi khas Kota Palembang yang merupakan bagian pada dalam pembahasan perancangan ini. Perancangan ini bertujuan mengajak para remaja dan masyarakat Kota Palembang agar melestarikan kearifan lokal dari kuliner Malbi Khas Kota Palembang ini
Analisis Kesulitan Siswa Dalam Menyelesaikan Soal-Soal Hots Setelah Pembelajaran Menggunakan Platform E-Learning
Authors: Claudia Situmeang Angel , Syahputra Edi
Published: April 2024

Penelitian ini bertujuan untuk mendeskripsikan kesulitan yang dialami siswa dalam menyelesaikan soal-soal HOTS setelah pembelajaran menggunakan Platform E-Learning. Jenis penelitian ini merupakan penelitian deskriptif dengan menggunakan pendekatan kualitatif. Penelitian ini dilaksanakan di SMA Negeri 7 Medan. Instrumen yang digunakan dalam penelitian ini yaitu tes soal HOTS dan pedoman wawancara. Adapun pengambilan subjek dilakukan dengan memberikan tes soal HOTS kepada 32 siswa kelas XI IPA 3. Sebelum memberikan tes soal HOTS, guru melaksanakan proses pembelajaran berdasarkan RPP yang telah dirancang oleh peneliti di kelas XI IPA 3 dengan menggunakan Platform E- Learning. Setelah itu dilaksanakan tes soal HOTS, dimana dari hasil tes tersebut dipilih masing-masing 2 subjek tiap kategorisasi penilaian HOTS yaitu siswa yang memiliki kemampuan rendah, sedang, dan tinggi. Teknik analisis data pada penelitian ini meliputi hasil tes dan hasil wawancara. Data yang diolah merupakan data kesulitan siswa dalam menyelesaikan soal Higher Order Thinking Skill. Soal yang digunakan untuk melihat kesulitan siswa adalah soal Barisan dan Deret bertipe Higher Order Thinking Skill dengan jumlah 5 soal yaitu terdiri dari 2 soal aspek menganalisis, 2 soal aspek mengevaluasi dan 1 soal aspek mencipta. Kemudian wawancara dilakukan untuk lebih menggali kesulitan yang dialami oleh siswa dalam menyelesaikan soal-soal HOTS pada materi Barisan dan Deret. Adapun indikator kesulitan dalam penelitian ini yaitu kesulitan dalam mengingat/memahami fakta, kesulitan dalam memahami konsep, kesulitan dalam operasi perhitungan dan kesulitan dalam memahami prinsip. Hasil penelitian ini menunjukkan bahwa: 1) subjek dengan kategori tinggi masih mengalami beberapa kesulitan dalam menyelesaikan soal-soal HOTS; 2) subjek dengan kategori sedang masih mengalami kesulitan dalam menyelesaikan soal-soal HOTS dengan indikator kesulitan yaitu kesulitan dalam mengingat/memahami fakta, kesulitan dalam memahami konsep, dan kesulitan dalam memahami prinsip; dan 3) subjek dengan kategori rendah mengalami kesulitan hampir pada semua soal dan memenuhi semua indikator kesulitan
Evaluasi Kinerja Dinas Pemberdayaan Perempuan, Perlindungan Anak Dan Pemberdayaan Masyarakat Dalam Pengendalian Kekerasan Anak
Authors: Audina Fattia , Yana Harahap Helly , Asrianingsih Dewi
Published: April 2024

Permasalahan pada penelitian ini yaitu tindakan kekerasan terhadap anak menjadi bentuk perlakuan baik secara fisik ataupun emosional dan kekerasan seksual di kota tanjungpinang, dan selama 3 tahun terakhir kasus kekerasan terhadap anak  terus meningkat. Dimana kasus kekerasan terhadap anak terjadi mulai dari kekerasan fisik, kekerasan psikis, kekerasan seksual dan kasus perdagangan anak. Penelitian ini bertujuan untuk menganalisis evaluasi terhadap kinerja dinas pemberdayaan perempuan, perlindungan anak dan pemberdayaan masyarakat (DP3APM) dalam pengendalian kekerasan anak di kota Tanjungpinang. Metode yang digunakan pada penelitian ini yaitu pendekatan kualitatif, Berdasarkan jenis datanya deskriptif kualitatif bermaksud untuk memperoleh informasi mengenai evaluasi kinerja lembaga dinas terkait. Hasil yang diperoleh pada penelitian ini dengan mengkaji penelitian terdahulu yaitu peran pemerintah sebagai regulator, peran pemerintah sebagai dinamisator, peran pemerintah sebagai fasilitator. Kesimpulan yang dapat diambil mengenai penelitian ini berdasarkan UU perlindungan anak No 23 tahun 2002 kekerasan terhadap anak merupakan perbuatan semena-mena yang dilakukan kepada anak, baik secara fisik, psikis, seksual, dan penelantaran oleh orang yang seharusnya menjadi pelindung pada seorang anak. Berbagai upaya dan kegiatan dalam mencegah terjadinya kekerasan terhadap anak baik melalui sosialisasi, diseminasi, dan lain-lain sudah dilakukan dan diharapkan terjadinya perubahan perilaku dalam pola mendidik anak tanpa kekerasan.
Analisis Porositas Dan Konduktivitas Hidraulik Batupasir Formasi Kampung Baru, Balikpapan Dan Pulau Balang, Daerah Samarinda, Kalimantan Timur
Authors: Al Fatihah Ainayah , Dina Devy Shalaho , Magdalena Henny , Trides Tommy , Oktaviani Revia
Published: April 2024

penelitian ini memiliki tujuan dan masalah untuk mengetahui nilai porositas, nilai Konduktivitas hidrolika dan hubungan antara nilai Porositas dan Konduktivitas Hidrolik batupasir formasi kampungbaru, Balikpapan dan pulau balang dengan. Pada penelitian ini menggunakan penelitian ini menggunakan analisis inti fisik batuan untuk mengetahui nilai porositas dan Konduktivitas hidrolik. Nilai porositas yang telah diuji pada Formasi kampungbaru, untuk  batupasir didapatkan rata-rata nilai 14,37% (sedang). Formasi Balikpapan 23.85% (sangat baik). Dan Formasi Pulau Balang 25,35 % (sangat baik). Uji Nilai Konduktivitas hidrolik mendapatkan nilai rata-rata pada Formasi Kampungbaru 3,56E-03 cm/s (Pasir Halus), Formasi Balikpapan 3,27E-03 cm/s (Pasir Halus dan lanau) Dan Pulau Balang 1.00E-03 cm/s (Pasir Halus dan lanau). Berdasarkan  Analisis hubungan porositas dan Konduktivitas Hidrolik yang dibuat pada formasi dimana apabila nilai porositas baik maka nilai Konduktivitas hidrolik pun ikut meningkat. Dalam hal ini pun dapat dilihat dari nilai r2 masing-masing formasi yaitu Kapungbaru adalah  (r2  = 0,911), Balikpapan (r2 = 0,913) dan Pulau Balang (r2  =  0,940).
Systematic Literature Review (Slr) : Keamanan Dalam Sistem Informasi
Authors: Nisfu Melati Sukma Wahyu , Reynata Ardhito , Auzini Yasmine Dhivon , Maulana Putra Pratama Dika
Published: April 2024

Keamanan sistem informasi menjadi sangat penting karena dalam era digital saat ini, manusia semakin mengandalkan teknologi informasi dan menyimpan data sensitif secara digital. Makalah ini melibatkan pencarian dalam berbagai sumber literatur, termasuk makalah/jurnal yang terkait dengan keamanan sistem informasi. Sebanyak 100 makalah/jurnal yang relevan yang diterbitkan antara tahun 2019 sampai dengan tahun 2023 telah diidentifikasi dan diseleksi. Temuan utamanya adalah tantangan dalam keamanan informasi yang umum dibahas termasuk Kebocoran data, Penyimpanan data yang tidak terstruktur sehingga menyebabkan data mudah hilang, kurangnya perhatian akan pentingnya keamanan dalam lingkup sistem informasi, dan kurangnya solusi yang menyediakan pemantauan secara real-time. Dan praktik terbaik untuk meminimalisir terjadinya masalah dalam keamanan sistem informasi meliputi penggunaan firewall yang lebih canggih, mengembangkan aplikasi yang sudah ada, melakukan audit keamanan sistem informasi secara rutin. Tinjauan literatur sistematis memberikan gambaran umum terbaru tentang penelitian keamanan sistem informasi yang mutakhir dan mengidentifikasi topik-topik utama untuk penelitian di masa depan. Temuan-temuan ini dapat membantu manusia menilai postur dan strategi keamanan mereka pada era digital saat ini.
Analisis Terjadinya Penolakan Pkpu Terhadap Pt Garuda Dan Terbebas Dari Pailit Di Masa Pandemic
Authors: Ali Putra Pratama Jechyko , Nur Kaffa Ismail Muhammad , Suryanti Nyulistiowati , Yuanitasari Deviana
Published: April 2024

Salah satu aturan yang dapat menangani permasalahan debitor yang tidak mampu membayar hutangnya terhadap resistor adalah dengan kepailitan. Pada dasarnya terjadi beberapa perubahan dalam pengaturan terkait dengan kepailitan. Failissementsverordering merupakan suatu aturan kepailitan yang prosesnya itu lama dan hasilnya tidak bisa dipastikan sehingga peraturan tersebut dirasa kurang karena kurang bisa untuk diandalkan. Setelah aturan tersebut lahir perpu no 1 tahun 1998 yang merupakan perpu pengganti dari aturan sebelumnya yang pada akhirnya perpu tersebut itu disahkan menjadi Undang-Undang Nomor 4 tahun 1998 mengenai kebaikan yang penyempurnaannya sekarang ini yang telah disahkan ialah Undang-Undang Nomor 37 tahun 2004 mengenai kepailitan. Salah satu contoh kasus permohonan PKPU adalah permohonan PKPU yang disampaikan oleh PT My Indo Airlines yang mengajukan permohonan PKPU terhadap Garuda Indonesia sebagaimana dalam putusan Nomor 289/Pdt.Sus-PKPU/2021/PN.Niaga.Jkt.Pst. Dalam permohonan PKPU tersebut ditolak oleh majelis hakim yang menjadikan Garuda Indonesia terhindar dari kepailitan. Pertimbangan majelis hakim menolak permohonan PKPU tersebut karena pemohon PKPU tidak dapat membuktikan bahwa Garuda Indonesia memiliki utang yang sudah jatuh tempo dan dapat ditagih atau dalam hal ini dapat dikatakan tidak dapat membuktikan bahwa Garuda Indonesia dalam masa insolvensi.
Enhancing Recognition in Multimodal Biometric Systems: Score Normalization and Fusion of Online Signatures and Fingerprints
Authors:   L.E.R.I.C.A. University of Badji Mokhtar P. Box 12, 23000 Annaba, Algeria, HAFS Toufik , ZEHIR Hatem ,   L.E.R.I.C.A. University of Badji Mokhtar P. Box 12, 23000 Annaba, Algeria, HAFS Ali ,   Department of Physics ,University of Chadli Bendjedid, P. Box 73, El Tarf, 36000 Algeria
Published: April 2024

Multimodal biometrics employs multiple modalities within a single system to address the limitations of unimodal systems, such as incomplete data acquisition or deliberate fraud, while enhancing recognition accuracy. This study explores score normalization and its impact on system performance. To fuse scores effectively, prior normalization is necessary, followed by a weighted sum fusion technique that aligns impostor and genuine scores within a common range. Experiments conducted on three biometric databases demonstrate the promising efficacy of the proposed approach, particularly when combined with Empirical Modal Decomposition (EMD). The fusion system exhibits strong performance, with the best outcome achieved by merging the online signature and fingerprint modalities, resulting in a normalized Min-Max score-based Equal Error Rate (EER) of 1.69%.
A PROPOSAL OF DIGITAL IDENTITY MANAGEMENT USING BLOCKCHAIN
Authors: BRĂCĂCESCU RALUCA VERONICA , MOCANU ŞTEFAN , IONIŢĂ ANCA DANIELA , BRĂCĂCESCU CARMEN
Published: April 2024

Digital identity is the representation of a person in the digital environment. Nowadays, digital identity has become a very important topic when most activities are moved to the online world. To be secured and respect data privacy, this digital identity must be controlled by its owner, not any other third parties. This paper aims to propose a system for digital identity, presenting its architecture, features, and implementation specifications. This system brings advantages that will also be exposed along with real-life use case scenarios, all proving the necessity of transitioning to a modern identity management model like the Self-Sovereign Identity model. The Self-sovereign identity model is based on blockchain and is fundamental for the digital identity system conceived through research.
FETAL 3D-ECHO CLASSIFICATION AND SEGMENTATION USING COLOR AND TEXTURAL FEATURES FOR TR DETECTION
Authors: PRIYA MUTHUMANICKAM BHAGAVATHI , RAMAKRISHNAN CHANDRAN , KARTHIK SUBBURATHINAM
Published: April 2024

Tricuspid regurgitation (TR) is a condition in which the valve between the right atrium and right ventricle does not close properly. Therefore, blood leaks backward into the upper right chamber. Most commonly, tricuspid regurgitation is caused by an enlarged right ventricle. In this paper, a novel deep learning technique called Tricuspid regurgitation identification in the fetal heart (TRI-FH) approach has been proposed, for identifying TR in the early stages. The gathered 3D-echo images are pre-processed to improve the quality of the images. The feature extraction techniques namely color-level co-occurrence matrix (CLCM) and grey-level co-occurrence matrix (GLCM) are applied on both RGB and grey images. The extracted features are extracted using the wrapper method and the unsupervised dimension reduction technique namely independent component analysis (ICA) is used to reduce the dimension of extracted features. Afterward, the deep learning-based Ghost network is used for classifying normal, Mild TR, and severe TR cases. The classified TR cases are fed to the segmentation phase for segmenting the affected valve of the fetus. The experimental TRI-FH approach achieves a total accuracy of 98.07 %. As compared to existing techniques, the proposed TRI-FH method shows higher performance in terms of accuracy, precision, recall, specificity, and F1 score. The proposed TRI-FH model enhances the total accuracy by 95.64 %, 97.82 %, 93.21 %, and 95.67 % better than ResNet, DenseNet, LinkNet, and U-Net respectively.
DEEP VEIN NET: DEEP VEIN THROMBOSIS IDENTIFICATION VIA SOOTY TERN OPTIMIZED DEEP LEARNING NETWORK
Authors: CROSS JOSEPH BASTIN ROGERS , JEBADURAI IMMANUEL JOHNRAJA , PAULRAJ GETZI JEBA LEELIPUSHPAM , JEBADURAI JEBAVEERASINGH , VARUVEL MULLI MARY
Published: April 2024

Deep vein thrombosis (DVT) occurs when thrombosis (blood clots) forms in veins far below the skin's surface due to veins or sluggish blood flow injuries. An obstruction in blood flow through a vein could be partially or completely caused by blood clots. DVTs typically occur in the thigh, lower leg, or pelvis, yet can also occur in other body parts, such as the brain, liver, intestines, arm, or kidney. This research proposes a novel Deep Vein Net, integrating deep learning-based dilated CNN and Sooty Tern optimization to detect DVT from CT and MRI images efficiently. The input CT and MRI images are pre-processed to eliminate noise artifacts using the Discrete Wavelet Transform (DWT). Furthermore, the pre-processed images are fed into a Dilated convolutional neural network (Dilated CNN) for feature extraction to extract the most pertinent features. Lastly, the STO algorithm uses the fuzzy Extreme Learning Machine of thrombosis stages normal and DVT to select the best features for additional classification. Metrics like rec, spe, acc, pre, and F1 scores were used to assess the Deep Vein Net's performance. The suggested method achieves a classification accuracy of 99.25 % when identifying DVT cases.
AFRICAN VULTURE OPTIMIZED INTEGRATED CONTROL TECHNIQUE FOR PV-FED OPEN-END WINDING INDUCTION MOTOR PUMP APPLICATION
Authors: VENUGOPALAN KAVYA , VARGHESE JEGATHESAN , THANKASWAMY JARIN
Published: April 2024

Open-end winding induction motors (OEWIM) have gained much attention, and they are used for solar photovoltaic (PV) fed pumping applications as a compromise alternative to multi-level inverters. Solar irradiance conditions further exacerbate the nonlinear control problem, resulting in significant loss of power and low reliability, which affects motor operation. To overcome these issues, this paper presents an optimized integrated control technique-based PV integrated three-level dual inverter fed Open-end winding induction motors for pumping application. An integrated African vulture optimization algorithm and scalar coupled pulse width modulation (AVO-SCPWM) based control techniques are proposed to extract the maximum power from the solar PV source and control the induction motor pump. Here, the AVO-based maximum power point tracking (MPPT) technique adjusts the modulation index (ma) by insolation and temperature. The proposed technique balances the zero-sequence current, reduces THD, and reduces the switching losses over the inverter. The proposed work is evaluated in MATLAB/Simulink software and compared with the existing conventional induction motor (IM), Conventional OEWIM Drive, and scalar decoupled PWM-based IM techniques under two climatic conditions. Thus, the simulation results demonstrate that the proposed technique accomplishes better than the existing techniques.
Understanding the Impact of Parent-Child Relationships on Emotion Regulation: A Comprehensive Review
Authors:   Department of Publication and Extension, Kampala International University Uganda, Marcus Asiegbu K.
Published: April 2024

This paper explores the impact of parenting on adolescents' self-regulation, emphasizing the importance of parental socialization in shaping individuals' beliefs, worldviews, and behaviors. It highlights that effective emotion regulation in children is associated with parents' emotional support, positive affect, emotion coaching, and joint strategies. Conversely, difficulties in emotion regulation in adolescents are linked to parents' psychological control, permissiveness, expressed anger, and criticism. Furthermore, the study reveals that adolescents experience more positive affect when in the presence of their parents compared to when they are alone, indicating ongoing parental influence on emotion regulation throughout adolescence. Consequently, the paper underscores the need for practitioners working with parents and families to develop intervention and prevention efforts targeting three primary ways parents impact emotion regulation: modeling/observation, specific parenting practices related to emotion, and families' emotional climate. These efforts should focus on enhancing parents' emotion-regulation skills and teaching emotion-coaching techniques that emphasize warmth, responsiveness, and setting limits. Keywords: Parent-Child Relationships, Emotion Regulation, Adolescents, Parenting Practices, Intervention
An in-depth investigation of the widespread effects of child abuse on development and wellbeing
Authors:   Department of Public Administration, Kampala International University Uganda, Ejim Jacob Prince
Published: April 2024

The problem of child abuse is an everywhere phenomenon throughout the world that leads to the most detrimental effects on the children in the question of their development and general health. This article makes an effort to convey the complexity of child abuse by focusing on its physical-emotional-sexual-neglect dimensions. The World Health Organization's exhaustive definition of the concept furnishes the basis for the acknowledgement of the injuries that one person can suffer from the relationships based on care, authority, or dependency. Approximately 40 million children around the world were abused last year regardless of whether they were wealthier, belonged to a particular culture or were badly educated. The UN Convention on the Rights of the Child features childhood its age from the moment of birth until 18 years recognizing the fact that individuals at this age have specific vulnerabilities which are inherently tied to their dependence on others. The session next proceeds into addressing child abuse, with its different dynamics and levels of complexity. Brief description of different kinds of mistreatment including violence, sexual, emotional, and neglect specifying the urgent necessity to eliminate sexual abuse – especially the already existing one-in-ten girls globally. The consequences of child maltreatment on behavioral development throughout the various periods, including infant period through adolescence are considered. Stages of the syndicated approach will shed the light on the particular difficulties and bad results, promoting the application of the relevant measures. Issues concerning common behavioral signals include but are not limited to difficulty in identifying the signs and the importance of being able to sign them, which pays a big role in fighting the issue of abuse. Finally, the paper states that the world's dedication should never fail if our intentions are to end abuse among children. The main reason why every child ought to be ensured of a safe environment so that they can all flourish is that the diverse types of child abuse and the long-lasting impacts on the development of behavior need to be addressed in their entirety. Keywords: Child Abuse, Behavioral Development, World Health Organization, UN Convention on the Rights of the Child, Sexual Abuse, and Responsibility.
Assessing the Impact of Agrochemical Misuse on Health and Environment: A Case Study of Ghanaian Agriculture
Authors:   Faculty of Biomedical Kampala International University Uganda, Ukwu Friday Kelvin
Published: April 2024

The escalating global population demands heightened food production, prompting intensified agricultural practices worldwide. However, this surge in agricultural activity, particularly in underdeveloped regions like Ghana, often leads to the indiscriminate and excessive use of agrochemicals. This study delves into the ramifications of agrochemical misuse on human health and the environment, focusing on Ghana's agricultural sector. Through an examination of scientific evidence and empirical data, the study highlights the prevalence of agrochemical residues in food products and their association with various health conditions. Additionally, it scrutinizes the ecological consequences of agrochemical pollution, emphasizing the need for sustainable farming practices. By assessing the challenges posed by agrochemical misuse, this research advocates for the adoption of organic farming as a viable solution for achieving agricultural sustainability and safeguarding human and environmental well-being. Keywords: Agrochemicals, Agriculture, Health, Environment, Ghana, Pesticides, Organic farming, Sustainable agriculture
Exploring Phytochemicals for Diabetes Management: Mechanisms, Efficacy, and Future Directions
Authors:   Eastern New Mexico University Portales NM USA, Onukwuli Chimezie O. , zuchukwu Chisom E. I ,   New Mexico Highlands University Las Vegas NM USA, Ugwu Okechukwu Paul-Chima ,   Department of Publication and Extension, Kampala International University Uganda
Published: April 2024

In the realm of global health diplomacy, diabetes mellitus undoubtedly poses a significant challenge. Furthermore, there is a pressing need to explore alternative and complementary therapies. Phytochemicals, which are naturally occurring bioactive compounds found in plants, exhibit distinct biochemical properties, rendering them promising candidates for diabetes management. This review focuses on the potential of various classes of phytochemicals, including polyphenols, alkaloids, terpenoids, organosulfur compounds, and polysaccharides, in diabetes management. Each class demonstrates unique mechanisms of action, contributing to therapeutic effects such as enhancing insulin sensitivity, reducing carbohydrate digestion and glucose absorption, regulating antioxidant stress, inflammation, and glucose metabolism. While successful preclinical trials provide valuable insights, further rigorous clinical trials are imperative to ascertain the therapeutic efficacy, optimal dosage, bioavailability, and potential interactions with concomitant medications. Understanding the functional pathways of plant-derived substances is crucial, as it enables the formulation of precise strategies for incorporating them as dietary supplements for individuals with diabetes mellitus. Keywords: Phytochemicals, diabetes mellitus, insulin sensitivity, glucose metabolism, oxidative stress, and inflammation.
Compulsive Desires
Authors: Otero Verzier Marina
Published: April 2024

In this essay I analyse how energy dreams and epistemologies, constructed on cravings for productivity and profit, connect the spaces that epitomise the ‘Cartesian enclosure’ with the technologies and spaces of everyday life. I examine how destructive habits of extracting, procuring and consuming energy follow predictions that assume the inevitability of growth. Estimates that, even in the face of climate catastrophe, render the need for more energy inevitable and rely on finding new fixes rather than embracing other forms of living. Focusing on the case of lithium extraction in Atacama, I address the struggles sustained by indigenous communities for their lives, sovereignty and rights. Battles that emphasise how, in what has been described as ‘green colonialism’, the development of the ‘green energy futures’ too often is to the detriment of indigenous peoples.
ANALYSIS OF THE GENOTYPES OF INFLUENZA A H5N1 IN BULGARIA 2021-2023
Authors: Goujgoulova Gabriela , Zaharieva Krasimira
Published: April 2024

Circulating HPAI virus H5N1 can be traced back to the original A/goose/Guangdong/1/96 strain. During the epidemiological years 2022 and 2023, a remarkable number of HPAI H5N1 virus isolates were detected and reported in a diverse range of hosts, including wild and domestic birds, mammals and humans, in more than 28 European countries. Interestingly, the potential for cross-species transmission highlights the complex dynamics of viral spread among these different susceptible species. The persistently emerging outbreaks of HPAI H5N1 in animals and humans demonstrate the need for comprehensive understanding of this virus and its public health implications, as well as for detailed genomic mapping and characterization. With increasing reports of human infections and the potential for devastating economic consequences in industrial livestock production, it is imperative to deepen analyzes of HPAI H5N1 to effectively respond to the continued spread of the virus in animals, prevent future outbreaks and transmission to the people. To provide a comprehensive analysis of the emergence and spread of HPAI H5N1, it is necessary to examine the genetic characteristics, mutations in the viral genome, and the evolution of the virus, and to evaluate the effectiveness of current prevention and control strategies.
Problems to Ponder
Authors: Thibodeau Tiffany , Purdasseea Sooryadev
Published: April 2024

Problems to Ponder provides 28 varying, classroom-ready mathematics problems that collectively span PK–12, arranged in the order of the grade level. Answers to the problems are available online. Individuals are encouraged to submit a problem or a collection of problems directly to mtlt@nctm.org. If published, the authors of problems will be acknowledged.
Iniciação às ciências na educação infantil: brincar e experimentar com a natureza
Authors: Massabni Vânia Galindo
Published: April 2024

Neste artigo, o objetivo é discutir as perspectivas do ensino de Ciências para a educação infantil, ajustando-as à faixa etária e propósitos formativos desse nível de ensino no Brasil, que prevê a formação integral para além do cuidar. Parte-se do princípio da construção de conhecimentos desde o nascimento da criança, conforme Piaget, e de pontos tidos como chave para se pensar o ensino e aprendizagem de Ciências, considerando os avanços da área. O ajuste dos pontos-chave, uma vez que conceituações e a formulação de hipótese, entre outros aspectos, não são ainda factíveis, refere-se à valorização da investigação, da exploração do meio natural e da experimentação pela criança na escola, visando auxiliá-la no estabelecimento de relações lógicas em que tem papel ativo na realidade em vive. Defende-se que a educação infantil seja um momento de iniciação às Ciências com noções construídas no brincar e experimentações com a natureza, em hortas, jardins e atividades didáticas a elas relacionadas, em que objetivo e planejamento de ensino sejam suportes à construção de conhecimento nessa fase. São elencados três estudos, um dos quais critica a limitação das atividades de colorir e de cópia no contato da criança com conteúdos de Ciências. Alternativas para o ensino exemplificam as relações e ciclos nos temas como as abelhas sem ferrão, germinação e água, com coleta de água de chuva para regar o jardim. Portanto, a iniciação às Ciências pelo brincar e experimentar com a natureza são pautas para mudanças no ensino de Ciências.
Die Sperrklausel ist keine Lösung
Authors: Quaritsch Luise
Published: April 2024

Es ist fraglich, ob es tatsächlich die Anzahl kleiner Parteien im Europaparlament ist, die dessen Handlungsfähigkeit gefährdet. Eher geht die Gefahr wohl von der zunehmenden Anzahl an rechtsextremen und antieuropäischen Abgeordneten aus, die es sich zum Wahlziel gemacht haben, eine Sperrminorität zu erreichen und damit das Europaparlament zu blockieren – und die nicht notwendigerweise aus kleinen Parteien stammen. Um die Handlungsfähigkeit des Parlaments zu sichern, sollten sich Politiker:innen darauf konzentrieren, Wählerstimmen für eine stabile pro-europäische Mehrheit zurückzugewinnen.
No positive effects of biodiversity on ecological resilience of lake ecosystems
Authors: Su Haojie , Li Yanling , Zhong Misha , Ma Ruijing , Chen Jianfeng , Rao Qingyang , Feng Yuhao , Ma Suhui , Chen Jun , Wang Haijun , Jeppesen Erik , Xie Ping
Published: April 2024

Ecological resilience is critical for ecosystems to persist in the face of perturbations without shifting to a different state. Global biodiversity loss in multiple ecosystems is considered to be associated with decreasing ecological resilience and increasing the risk of ecosystem collapse. However, how temporal changes in biodiversity affect ecological resilience in natural ecosystems remains poorly elucidated. By analyzing subfossil records of diatoms, chironomids, and cladocerans from 53 lake sediment cores across the globe, we found that species richness showed an increasing trend with time, while beta diversity and ecological resilience presented a decreasing temporal trend when ecosystems are approaching the abrupt shift. Asynchronous fluctuations among species and temporal stability at species level are suggested to be the mechanisms that contribute to the maintenance of temporal community stability. We found species richness and beta diversity have positive effects on species asynchrony but negative effects on species stability. However, we found that species asynchrony and species stability had negative relationships with ecological resilience, with species richness and beta diversity overall having no positive effects on ecological resilience. We highlighted that biodiversity effects on ecological resilience are not only the role of species richness, but also the species assemblage and network complexity of species-species interactions. Our study indicates that increased species diversity and community heterogeneity may be not beneficial for the ecosystem to recover from disturbances at a lake ecosystem scale, which has great implications for the assessment of ecological resilience and predicting ecosystem collapse in future global environmental change scenarios.
Allogeneic Stem Cell Transplantation in Treatment of Refractory/Relapsed Lymphomas
Authors:   Department of Hematology, Regional Institute of Oncology, Iasi, Romania, BERESTEANU Valeria , LUPU Elizabeta ,   Department of Hematology, Regional Institute of Oncology, Iasi, Romania, DUMITRU Roxana ,   Department of Hematology, Regional Institute of Oncology, Iasi, Romania, PELIN-DOLACHI Elena ,   Department of Hematology, Regional Institute of Oncology, Iasi, Romania, ANTOHE Ion ,   Department of Hematology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, DASCALESCU Angela Smaranda ,   Department of Hematology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: April 2024

Aim: To assess the outcome of allogeneic stem cell transplantation in patients with refractory/relapsed lymphoma. Methods: Between 2021 and 2023, 6 patients with refractory/relapsed (R/R) lymphoma underwent allogeneic stem cell transplantation at the Bone Marrow Transplant Department of Regional Institute of Oncology Iasi- 4 with Hodgkin lymphoma (HL), 1 with primary mediastinal large B-cell lymphoma (PMBCL) and 1 with Mycosis fungoides (MF). All patients received reduced intensity conditioning chemotherapy, combining Fludarabine, Busulfan or Melphalan. The prophylaxis of graft-versus-host-disease (GVHD) was made with Cyclophosphamide (n=4), Tacrolimus and Mycophenolate mofetil (n=5), Cyclosporine (n=1). Results: The post transplant evolution of the patients was marked by infectious complications (n=5), digestive mucositis (n=4) and viral reactivations (n=4). One patient with HL had acute cutaneous and hepatic graftversus-host disease(GVHD) and two had chronic hepatic and intestinal GVHD. Imaging evaluation by PETCT on day +100 shows a complete response in three patients with HL and progressive disease in the patient with PMBCL and one patient with HL. Conclusion: Despite the introduction of increasingly effective treatment options for R/R lymphoma, transplantation continues to play an important role in the management of these patients. Allogeneic transplantation is an effective therapy for advanced aggressive lymphoma, limited by treatment-related toxicity and mortality.
Multiple Myeloma and Solid Tumors – a Frequent Rarity –
Authors:   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, CIRLAN Loredana , BADELITA Sorina ,   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, CORIU Daniel ,   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest
Published: April 2024

Objective: Multiple Myeloma is defined by the proliferation of monoclonal B leukocytes (plasmacytes) in the bone marrow, which results in the production of monoclonal proteins into the urine or blood. With the development of novel therapies, the management of multiple myeloma has improved over time. However, an increasing number of patients now present with a history of solid tumors related to myeloma, which may be observed during the course of the patient's therapy. Case presentation: We present the case of a 53-year-old man who was referred to our department for additional testing to distinguish between multiple myeloma and bone metastases. The patient had a personal history of colonic cancer, which was diagnosed 5 months prior, and osteolytic lesions discovered on the abdominal CT scan. Increased atypical plasmocytic cells were observed in the bone marrow biopsy, and serum IgG kappa monoclonal protein were also positive. Conclusion: The case highlights the potential for concurrent hematologic and solid cancer coexistence.
Chronic Myeloid Leukemia Presenting with Megakaryocytic Blast Crisis: a Case Report with a Favorable Outcome
Authors:   Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania, MARCOCI Alexandra , MANOLACHE Raluca Mihaela ,   Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania, FLORESCU Radu Bogdan ,   Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania, BARBU Doina ,   Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania, GRADINARU Florentina ,   Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania, ANGELESCU Silvana ,   Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania, COLITA Andrei ,   Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania
Published: April 2024

Chronic myeloid leukemia (CML) belongs to the chronic myeloproliferative neoplasms, a clonal disorder of pluripotent hematopoietic stem cells, arising because of a hallmark genetic anomaly- reciprocal translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, which generates the BCR::ABL fusion gene. The disease can have a biphasic/triphasic evolution, comprised of an accelerated phase and a terminal blast phase (usually biphasic when blastic phase is lymphoid in nature). Most cases present during the chronic phase of the disease, with only 10% of cases presenting in the blast phase. Megakaryocytic blast crisis is an unusual form of presentation, accounting for less than 3% of cases and it commonly carries an unfavorable prognosis compared to the classic myeloid, lymphoid or even mixed lineage blast crises. Aim: To bring forth an unusual case of CML presenting with megakaryocytic blast crisis and the therapeutic challenges associated with this particular presentation, unexpectedly ending with a favorable outcome. Matherial and methods: we hereby present the case of a 50 year old female patient, diagnosed in 2015 with CML- megakaryocytic blast crisis, who underwent treatment with a tyrosine kinase inhibitor (TKI)- imatinib and intensive chemotherapy regimen 3+7, without satisfactory response. A second induction chemotherapy regimen followed (MEC), alltogether with the same TKI and cytoreductive treatment (hydroxyurea/HU), but still without achieving a complete remission. Thus, the TKI was switched to dasatinib and complete normalisation of blood counts followed (including thrombocytes). However, there was still inadequate molecular and cytogenetic response. Therefore, TKI dosage was increased and after 4 months the patient achieved complete remission, with no detectable BCR::ABL transcript. She spent 9 years on the same TKI until important pleural effusion developed, which required switching to another 2nd generation TKI- bosutinib, based on the patients age, genetic profile and commorbidities. She is still in complete remission without detectable BCR::ABL transcript/Philadelphia chromosome to this day (2024). Results and conclusions: this is the case of a rare presentation of CMLmegakaryocytic blast crisis, who underwent both TKI and intensive chemotherapy induction regimens, marked by a favorable unexpected outcome.
Overview of ADAMTS13 Protein in Diagnosis and Patient Management of TTP
Authors:   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, GHERGHE Georgiana , USCATESCU Valentina ,   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, POPA Delia Codruta ,   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, PREDA Diana ,   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, VASILACHE Didona ,   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, HIMCINSCHI Mihai Emanuel ,   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, SANDU Horia ,   Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, CORIU Daniel
Published: April 2024

The accurate diagnosis and effective management of Thrombotic Thrombocytopenic Purpura (TTP), a rare but life-threatening hematologic disorder, rely critically on the assessment of ADAMTS13 activity. ADAMTS13, a von Willebrand factor-cleaving protease, plays a pivotal role in the pathophysiology of TTP. This review synthesizes current understanding and recent advancements in the role of ADAMTS13 in the diagnosis and therapeutic monitoring of TTP, with a specific focus on the implementation of a fluorescence resonance energy transfer (FRET)-based assay for ADAMTS13 activity. Our retrospective analysis of 50 suspected TTP cases, including 19 confirmed diagnoses, revealed that the FRET-based assay significantly improved the sensitivity and specificity of TTP diagnosis compared to traditional qualitative methods. Furthermore, the FRET assay facilitated timely initiation of appropriate therapies and monitoring of disease activity, underscoring its utility in clinical practice. Our findings highlight the FRET-based ADAMTS13 activity assay's contribution to enhancing the diagnostic accuracy and management efficiency of TTP, suggesting its potential as a standard diagnostic tool in clinical settings. The review aims to provide a comprehensive overview for hematologists and laboratory medicine practitioners, encouraging the adoption of the FRET-based assay to improve patient outcomes in TTP management.
Non-Parametric CD-CAT Item Selection Strategy and Termination Rules Based on Binary Search Algorithm
Authors: Li Junjie , Zheng Huijing
Published: April 2024

CD-CAT plays a significant role in diagnosing and assessing students, contributing significantly to improving teaching effectiveness. However, in classroom teaching scenarios, unlike large-scale assessments where a large number of samples can be used to accurately estimate item parameters, non-parametric CD-CAT becomes the only feasible choice. Compared to parametric CD-CAT, non-parametric CD-CAT started later, and research mainly focuses on non-parametric item selection strategies. However, the existing non-parametric item selection strategies have the disadvantage of low efficiency, and there is little research on non-parametric termination rules. Therefore, this study proposes two more efficient item selection strategies: Non-Parametric Dynamic Binary Search (NDBS) and General Non-Parametric Dynamic Binary Search (GNDBS), as well as a non-parametric termination rule：Non-parametric Dynamic Binary Searching Index (NDBI). Simulation results show: (1) Under all conditions, the pattern classification accuracy rate of NDBS is higher than that of NPS, so NDBS can be used as the item selection strategy when there are no samples available. (2) In most cases, the performance of GNDBS is better than other item selection strategies, so GNDBS can be chosen as the item selection strategy when there are few samples available. (3) In variable-length tests, when the research objective is to obtain more accurate classification results, the critical value of the NDBI rule can be reduced; conversely, the critical values of the NDBI and GNDBI rules can be appropriately increased.
Auditing Corporate Reports and Financial Statements Externally: Truth or Mirage
Authors: Al-Adeem Khaled
Published: April 2024

The separation of ownership and management in the corporate model resulted in the need for an external party to certify the representation of the financial statements prepared by the corporation’s executive management of its financial position and the financial, cash and operational performance of its executive management. The existence of the corporation whose shares are traded in the market and stock exchanges also resulted in the emergence of a class in society, lurking for price fluctuation. Accounting has founded a concept that it is the servant of every rational decision maker. However, the concept of 'decision makers' in accounting is imaginary. Financial accounting has not been able for more than a century and until our present moment to provide a model for the financial statements and reports that the corporation is required to prepare and publish in response to their so-called needs of its financiers. The financial statements are prepared based on financial accounting standards, which represent the contemporary accounting truth. Such truth is impossible and is not a reflection of the economic reality on which the accounting entity is constructed. The external auditor’s approval of the corporate financial statements prepared by its executive management makes him its partner in preparing the financial statements and reports. What gives value to the opinion of the external party is his possession of the technical knowledge that gives him an advantage over the rest of the members of his society, and his independence from the executive management is the foundation of his work and professionalism. However, academic research in accounting and auditing casts doubt on the objectivity of the external auditor and even his ability to be independent, as their relationship is closer to cooperation than to opposition, representing the interests of the party absent from the contractual relationship between them. External auditing is the only profession whose practitioner must monitor whom he receives his fees in service to watch the interest a part that is absent in the contractual relationship. The external auditor does not provide the service of auditing the financial statements and reports of corporations as a community or voluntary service, but rather it is a service in exchange for covering his expenses and achieving a source of income. Also, work skills and dealing with the audit firm’s clients are of great importance in the audit firm, and leadership. Reliance on the one-partner model in implementing audit engagements is a source of risk. The external auditor is a product of his society. The doctrine that his society follows is his belief, and it is what affects his decisions. It is the balance of matters. Strengthening the independence of the external auditor, even in the presence of legislation, is not sufficient for the independence of the mind of the external auditor.
Family Status is a Personal Advantage and Legal Validity
Authors: Khalil Osama
Published: April 2024

The research aims, through its paragraphs, to the following: 1. Providing practical evidence for issues related to the family that appear disparate to the observer, but are closely related to the family situation in its most precise issues, such as personal data, ending with the exercise of legal rights and actions. 2. The research seeks to explain the impact of unifying the legal system within the family in strengthening the personal advantage of its members and their legal authority to acquire rights and bear obligations, and to explain the result of this unification in preserving, caring for, and cohesive the family.