bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction of Metal‐Organic Frameworks (MOFs)–Based Membranes and Their Ion Transport Applications
Authors: Fu Lulu , Yang Zhao , Wang Yuting , Li Ruirui , Zhai Jin
Published: December 2020

Biological ion channels with delicate ion transport functions exist widely in living organisms. Bioinspired solid‐state channels have emerged as promising platforms to mimic the working mechanism of natural channels. These channels help in understanding the mechanism of ion transport in biosystems and pave the way for applications in several interesting areas. Metal‐organic frameworks (MOFs), constructed by connecting metal ions and organic ligands, exhibit high porosity and unique pore structures. They also possess tunable pore sizes and are versatile in their compositions. And there are rich molecule/ion‐specific functional groups in the frameworks, which can intelligently modulate ion transport. Thus, MOFs are promising candidates that mimic biological ion channels. Herein, the recent progress in the design and construction of artificial solid‐state MOF‐based channels is focused on. The excellent ion transport properties of MOF‐based membranes are also summarized, including ionic selectivity, ionic rectification, and ionic gating. Following this, four emerging ion transport applications, namely, energy conversion, ion/molecule separation, biosensing, and water desalination, are highlighted. Finally, an outlook on future developments and challenges in this exciting research area is presented.
Software fault prediction using Whale algorithm with genetics algorithm
Authors: Alsghaier Hiba , Akour Mohammed
Published: December 2020

Software fault prediction became an essential research area in the last few years, there are many prediction and optimization techniques that have been developed for fault prediction. In this paper, an approach is developed by integrating genetics algorithm with support vector machine (SVM) classifier and Whale optimization algorithm for software fault prediction. The developed approach is applied to 24 datasets (12‐NASA MDP and 12‐Java open‐source projects), where NASA MDP is considered as a large‐scale dataset, and Java open source projects are considered as a small‐scale dataset. Results indicate that integrating Genetics algorithm with SVM and Whale algorithm improves the performance of the software fault prediction process when it is applied to large‐scale and small‐scale datasets and overcome the limitations that appeared in the previous studies.
Review of Chemical Reactivity of Singlet Oxygen with Organic Fuels and Contaminants
Authors: Al‐Nu'airat Jomana , Oluwoye Ibukun , Zeinali Nassim , Altarawneh Mohammednoor , Dlugogorski Bogdan Z.
Published: December 2020

Singlet oxygen represents a form of reactive oxygen species (ROS), produced by electronic excitation of molecular triplet oxygen. In general, highly reactive oxygen‐bearing molecules remain the backbone of diverse ground‐breaking technologies, driving the waves of scientific development in environmental, biotechnology, materials, medical and defence sciences. Singlet oxygen has a relatively high energy of about 94 kJ/mol compared to the ground state molecular O2 and therefore initiates low‐temperature oxidation of electron‐rich hydrocarbons. Such reactivity of singlet oxygen has inspired a wide array of emerging applications in chemical, biochemical and combustion phenomena. This paper reviews the intrinsic properties of singlet oxygen, emphasising the physical aspects of its natural occurrences, production techniques, as well as chemical reactivity with organic fuels and contaminants. The review assembles critical scientific studies on the implications of singlet oxygen in initiating chemical reactions, identifying, and quantitating the consequential effects on combustion, fire safety, as well as on the low‐temperature treatment of organic wastes and contaminants. Moreover, the content of this review appraises computational efforts, such as DFT quantum mechanical modelling, in developing mechanistic (i. e., both thermodynamic and kinetic) insights into the reaction of singlet oxygen with hydrocarbons.
Funktionen und Kontexte
Authors: Belz Malte
Published: December 2020

In diesem Kapitel erörtere ich in Kürze die Funktionen und anschließend zur Motivation des weiteren Vorgehens die Kontexte von Füllpartikeln. Abschnitt 3.1 zeigt die Multifunktionalität von Füllpartikeln anhand fünf häufig genannter Funktionen und stellt die Haltung dieser Arbeit zur Signal-Symptom-Debatte dar. Die postulierten Funktionen entstehen fast ausschließlich aus dem linguistischen Kontext von Füllpartikeln.
Zusammenfassung und Vergleich
Authors: Belz Malte
Published: December 2020

Tabelle 7.1 vergleicht die Ergebnisse von BeDiaCoc und GECO-FP bezüglich der phonetischen Füllpartikelformen, die nicht durch ihre Mikro-, Meso- und Makrokontexte erklärt werden. Vielmehr zeigt sich, dass sie in großen Teilen allgemeinen linguistischen Prinzipien unterliegen (beispielsweise Formdistribution und Ausgleichskürzung), die im nächsten Kapitel diskutiert werden. Ein Teil der Formvariabilität lässt sich mit sprecherspezifischen Eigenschaften erklären (beispielsweise Grundfrequenz).
Diskussion
Authors: Belz Malte
Published: December 2020

Im ersten Abschnitt dieses Kapitels diskutiere ich die gefundene kontextfreie Variation von Füllpartikeln. Im Anschluss daran werden die kontextbedingten Ergebnisse für die sequenziellen Kontexte und die Dialogstruktur eingeordnet, wonach diskutiert wird, wie Teile der Kontextbedingtheit durch die prosodische Phrasierung erklärt werden können.
Katatones Wandern mit Emil Kraepelin, Aloys Alzheimer, Henry Aloysius Cotton und anderen
Authors: Förstl Hans
Published: December 2020

Die Betriebsausflüge von Emil Kraepelins Königlich Psychiatrischer Klinik wurden unter den Mitarbeitern als „katatone Wanderungen“ bezeichnet. Im Jahr 1906 nahm eine erstaunliche Zahl deutscher und internationaler Gäste daran teil, Nicolas Achucarro, Henry Cotton, Eduard Flatau, Smith Ely Jelliffe, Gaetano Perusini, Edward Scripture, Maurycy Urstein und andere. Viele von Kraepelins Kollegen waren inspiriert von seinen Ideen und getrieben von wissenschaftlichem Enthusiasmus, der neben fachlichen Fortschritten in der Nervenheilkunde zu ganz unterschiedlichen Ergebnissen führte, von der Zahn- und Bauchchirurgie zu Psychoanalyse und Evidenz-basierter Medizin; von Rassenhygiene und Nationalismus zur Präsidentschaft des kommunistischen Rumänien.
Impact of bridging thrombolysis on clinical outcome in stroke patients undergoing endovascular thrombectomy: a retrospective analysis of a regional stroke registry
Authors: Seker Fatih , Bonekamp Susanne , Rode Susanne , Hyrenbach Sonja , Bendszus Martin , Möhlenbruch Markus A.
Published: December 2020

Purpose

It is unclear whether stroke patients undergoing endovascular thrombectomy (EVT) should receive bridging intravenous thrombolysis (IVT), if eligible. This study aims at analyzing the impact of bridging IVT on short-term clinical outcome.

Methods

In a prospective regional stroke registry, all stroke patients with premorbid modified Rankin Scale (mRS) score of 0–2 who were admitted within 4.5 h after onset and treated with EVT were analyzed retrospectively. Patients receiving “IVT prior to EVT” (IVEVT) were compared to those undergoing “EVT only” regarding the ratio of good outcome, discharge mRS, mRS shift, hospital mortality, and occurrence of symptomatic intracranial hemorrhage.

Results

In total, 2022 patients were included, 816 patients (40.4%) achieved good clinical outcome; 1293 patients (63.9%) received bridging IVT. There was no significant difference between both groups regarding the ratio of good outcome (IVEVT 41.4% vs. EVT 38.5%, P = 0.231), discharge mRS (median, IVEVT 3 vs. EVT 3, P = 0.178), mRS shift (median, IVEVT 3 vs. EVT 3, P = 0.960), and hospital mortality (IVEVT 19.3% vs. EVT 19.5%, P = 0.984). Bridging IVT was not a predictor of outcome (adjusted OR 1.00, 95% CI 0.79–1.26, P = 0.979). However, it was an independent predictor of symptomatic intracranial hemorrhage (adjusted OR 1.79, 95% CI 1.21–2.72, P = 0.005).

Conclusions

The results of the present study suggest that bridging IVT does not seem to improve short-term clinical outcome of patients undergoing EVT. Nonetheless, there might be a subgroup of patients that benefits from IVT. This needs to be addressed in randomized controlled trials.
2D-Perfusion Angiography Using Carbon Dioxide (CO2): A Feasible Tool to Monitor Immediate Treatment Response to Endovascular Therapy of Peripheral Arterial Disease?
Authors: Dewald Cornelia L. A. , Becker Lena S. , Maschke Sabine K. , Meine Timo C. , Meyer Bernhard C. , Wacker Frank K. , Hinrichs Jan B.
Published: December 2020

Purpose

Patients with peripheral arterial disease (PAD) or critical limb ischemia (CLI) require revascularization. Traditionally, endovascular therapy (EVT) is performed with iodinated contrast agent (ICM), which can provoke potential deterioration in renal function. CO2 is a safe negative contrast agent to guide vascular procedures, but interpretation of CO2 angiography is challenging. Changes in blood flow following iodine-aided EVT are assessable with 2D-perfusion angiography (2D-PA). The aim of this study was to evaluate 2D-PA as a tool to monitor blood flow changes during CO2-aided EVT.

Material and Methods

2D-PA was performed before and after ten EVTs (nine stents; one endoprosthesis; 10/2012–02/2020) in nine patients (six men; 65 ± 10y) with Fontaine stage IIb (n = 8) and IV (n = 1). A reference ROI (ROIINFLOW) was placed in the artery before the targeted obstruction and a target ROI (ROIOUTFLOW) distally. Corresponding ROIs were used pre- and post-EVT. Time to peak (TTP), peak density (PD) and area under the curve (AUC) were computed. The reference/target ROI ratios (TTPOUTFLOW/TTPINFLOW; PDOUTFLOW/PDINFLOW; AUCOUTFLOW/AUCINFLOW) were calculated.

Results

2D-PA was technically feasible in all cases. A significant increase of 82% in PDOUTFLOW/PDINFLOW(0.44 ± 0.4 to 0.8 ± 0.63;p = 0.002) and of 132% in AUCOUTFLOW/AUCINFLOW(0.34 ± 0.22 to 0.79 ± 0.59;p = 0.002) was seen. A trend for a decrease in TTPOUTFLOW/TTPINFLOWwas observed (− 24%; 5.57 ± 3.66 s–4.25 ± 1.64 s;p = 0.6).

Conclusion

The presented 2D-PA technique facilitates the assessment of arterial flow in CO2-aided EVTs and has the potential to simplify the assessment of immediate treatment response.
Dimensionen der Gesundheitskompetenz von Viertklässler*innen
Authors: Bollweg Torsten Michael , Okan Orkan , Freţian Alexandra , Janner Christina , Schulenkorf Tessa , Kirchhoff Sandra , Pinheiro Paulo , Bauer Ullrich
Published: December 2020

Hintergrund

Die Gesundheitskompetenz (GK) junger Menschen wird von Wissenschaft und Politik zunehmend als Ansatzpunkt für Gesundheitsförderung und Prävention anerkannt. Gerade die GK von Kindern wurde jedoch, insbesondere in Deutschland, bisher kaum erforscht. Diese Studie widmet sich dieser Forschungslücke, indem sie die GK von Viertklässler*innen in Nordrhein-Westfalen (NRW) untersucht.

Ziel der Arbeit (Fragestellung)

Die Fragestellung ist die explorative Beschreibung verschiedener Dimensionen der GK von Kindern unter Berücksichtigung sozioökonomischer Merkmale.

Material und Methoden

Es wurde eine schriftliche Klassenraumbefragung durchgeführt. Der Fragebogen, der speziell für 9‑ bis 10-Jährige entwickelt wurde, umfasst drei Dimensionen der GK: selbstberichtete allgemeine GK, funktionale GK (schriftsprachliche und numerische Fähigkeiten) und das Gesundheitswissen.

Ergebnisse

Es wurden 899 Schüler*innen an 32 Schulen befragt. Hierbei wurde eine hohe selbstberichtete GK ermittelt: die Befragten empfinden den Umgang mit Gesundheitsinformationen als einfach. Kinder mit niedrigem Wohlstand schneiden in allen Dimensionen der GK signifikant schlechter ab. Dies gilt mit Ausnahme der selbstberichteten GK auch für Kinder, die zuhause nicht nur Deutsch sprechen.

Schlussfolgerung

Diese Studie untersucht erstmals die GK von Viertklässler*innen in NRW. Wenngleich die selbstberichtete GK hoch ist, zeigt sich schon bei dieser jungen Altersgruppe ein sozialer Gradient hinsichtlich Wohlstand und Sprache. Die Forschungslage ist für das Kindesalter zwar noch lückenhaft und es besteht weiterhin Forschungsbedarf, die Ergebnisse deuten aber auf einen frühen Interventionsbedarf hin, um allen Kindern unabhängig von ihrer Herkunft zu ermöglichen, GK in dem Maß zu entwickeln, wie es der eigenen Gesundheit zuträglich ist.
Creativity in science and the ‘anthropological turn’ in virtue theory
Authors: Kidd Ian James
Published: December 2020

I argue that philosophical studies of the virtues of creativity should attend to the ways that our conceptions of human creativity may be grounded in conceptions of human nature or the nature of reality. I consider and reject claims in this direction made by David Bohm and Paul Feyerabend. The more compelling candidate is the account of science, creativity, and human nature developed by the early Marx. Its guiding claim is that the forms of creativity enabled by the sciences are ultimately valuable insofar as they advance our emancipation from a state of existential alienation. I end by encouraging future investigations of such vertical explanations of the significance of certain virtues in the context of scientific enquiry.
Vocally disruptive behaviour in nursing home residents in Ireland: a descriptive study
Authors: Nwogbunyama C. , Kelly B. D. , Cooney C.
Published: December 2020

Background:

Vocally disruptive behaviour (VDB) is relatively common in nursing home residents but difficult to treat. There is limited study on prevalence and treatment of VDB. We hypothesise that VDB is a result of complex interaction between patient factors and environmental contributors.

Methods:

Residents of nursing homes in south Dublin were the target population for this study. Inclusion criteria were that the residents were 65 years or over and exhibited VDB significant enough for consideration in the resident’s care plan. Information on typology and frequency of VDB, Interventions employed and their efficacy, diagnoses, Cohen-Mansfield Agitation Inventory scores, Mini-Mental State Examination scores, and Barthel Index scores were obtained.

Results:

Eight percent of nursing home residents were reported to display VDB, most commonly screaming (in 39.4% of vocally disruptive residents). VDB was associated with physical agitation and dementia; together, these two factors accounted for almost two-thirds of the variation in VDB between residents. One-to-one attention, engaging in conversation, redirecting behaviour, and use of psychotropic medication were reported by nurses as the most useful interventions. Analgesics were the medications most commonly used (65.7%) followed by quetiapine (62.9%), and these were reportedly effective in 82.6% and 77.2% of residents respectively.

Conclusions:

VDB is common, challenging, and difficult to manage. The study of VDB is limited by a variety of factors that both contribute to this behaviour and make its treatment challenging. Issues relating to capacity and ethics make it difficult to conduct randomised controlled trials of treatments for VDB in the population affected.
Effects of Zingiber officinale extract supplementation on metabolic and genotoxic parameters in diet-induced obesity in mice
Authors: Luciano Thaís Fernandes , De Souza Claudio Teodoro , Pinho Ricardo Aurino , Marques Schérolin de Oliveira , Luiz Gabriel Paulino , Tramontin Natalia dos Santos , Silveira Paulo Cesar Lock da , de Andrade Vanessa Moraes , Muller Alexandre Pastoris
Published: December 2020

Obesity is an epidemic associated with many diseases. The nutraceutical Zingiber officinale (ZO) is a potential treatment for obesity; however, the molecular effects are unknown. Swiss male mice were fed a high-fat diet (59 % energy from fat) for 16 weeks to generate a diet-induced obesity (DIO) model and then divided into the following groups: standard diet + vehicle; standard diet + ZO; DIO + vehicle and DIO + ZO. Those in the ZO groups were supplemented with 400 mg/kg per d of ZO extract (oral administration) for 35 d. The animals were euthanised, and blood, quadriceps, epididymal fat pad and hepatic tissue were collected. DIO induced insulin resistance, proinflammatory cytokines, oxidative stress and DNA damage in different tissues. Treatment with ZO improved insulin sensitivity as well as decreased serum TAG, without changes in body weight or adiposity index. TNF-α and IL-1β levels were lower in the liver and quadriceps in the DIO + ZO group compared with the DIO group. ZO treatment reduced the reactive species and oxidative damage to proteins, lipids and DNA in blood and liver in obese animals. The endogenous antioxidant activity was higher in the quadriceps of DIO + ZO. These results in the rat model of DIO may indicate ZO as an adjuvant on obesity treatment.
Early pregnancy overweight/obesity and length of residence among immigrants in Sweden: a pooled analysis of Swedish population registers between 1992 and 2012
Authors: López-Borbón Dilana , Löve Jesper , Juárez Sol P
Published: December 2020

Objective:

To examine whether the association between women’s origin and early pregnancy overweight and obesity (OW/OB) varies by length of residence in Sweden.

Design:

This cross-sectional observational study used pooled Swedish population register data from 1992 to 2012. Logistic regression models were run to estimate odds ratios (OR) of early pregnancy OW/OB and 95 % confidence intervals (95 % CI), comparing Swedish-born and immigrants by length-of-residence categories while adjusting for covariates.

Setting:

Sweden.

Participants:

In total, 1 771 821 pregnant women, 315 992 of whom were immigrants.

Results:

With longer residence in Sweden, more immigrant women from various origins exhibited higher odds of experiencing early OW/OB compared with Swedish-born women. Findings specifically showed increased odds of early pregnancy OW/OB with increasing length of residence for women born in Latin America, Europe-27 and Southeast Asia. For example, immigrant women from Latin America residing in Sweden for < 6 years showed similar odds as Swedish-born (OR≤ 5 years 0·92, 95 % CI 0·87, 0·98), while their longer residing counterparts showed higher odds than Swedish-born women (OR6–15 years1·21, 95 % CI 1·14, 1·28 and OR≥ 16 years 1·68, 95 % CI 1·59, 1·78). Mixed results were found for other origins.

Conclusions:

The current study suggests that host country conditions might play an important role in explaining OW/OB among some groups of immigrant women. Although further studies are needed to disentangle the mechanisms that generate these health inequalities, policy efforts should focus on immigrant reception and early integration to prevent pregnancy-related OW/OB.
Critical Mysticism or Critical Ethos? Intercultural Reflections on Stephen Palmquist’s Kant and Mysticism
Authors: Nelson Eric S.
Published: December 2020

This contribution offers a sympathetic historical and intercultural reflection on Stephen Palmquist’s work Kant and Mysticism. It examines (1) the appropriateness of this portrayal of Kant and mysticism in relation to its historical context (which encompasses figures such as Malebranche, Spinoza and Swedenborg), suggesting that Kant is committed to an account of rationality, ethical personhood and a ‘critical ethos’ in tension with mysticism; and (2) the inadequacy of Kant’s understanding of mysticism in the context of South and East Asian philosophical and religious discourses, indicating the need for an intercultural turn in the philosophy of religion.
Hurricane Maria Killed Mangroves Months After Storm
Authors: Joosse Tess
Published: December 2020

An overgrown channel between a lagoon and the ocean on the Puerto Rican island of Vieques created a backup of freshwater, disrupting the delicate balance of salinity in coastal mangrove forests.
Electron Density Depletion Region Observed in the Polar Cap Ionosphere
Authors: Bjoland L. M. , Ogawa Y. , Løvhaug U. P. , Lorentzen D. A. , Hatch S. M. , Oksavik K.
Published: December 2020

This paper presents and discusses electron density depletion regions observed with the incoherent scatter EISCAT Svalbard Radar (ESR) located at 75.43°N geomagnetic latitude. The data include several decades of measurements, which make them suitable for studying statistical features and characteristics of the ionospheric parameters. Here we focus on the electron density depletions and their dependence on diurnal and seasonal variations and solar activity. An electron density depletion region is identified in the ESR data in the early morning sector. This depletion region seems to be clearest during equinox and winter and moderate/high solar activity. An enhancement in the ion temperature is often co‐located with the electron density depletion region. The ion temperature enhancement could indicate that ion frictional heating is related to the electron density depletion region. However, during summer when the solar activity is low, the electron density depletion is not observed although the ion temperature is enhanced, suggesting that formation of the electron density depletion regions due to ion frictional heating may depend on the background effective temperature and O/N2 ratio. In addition, seasonal changes in the solar zenith angle could also contribute to the formation of the depletion region.
The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response
Authors: Coleman Niamh , Zhang Bingnan , Byers Lauren A. , Yap Timothy A.
Published: December 2020

The therapeutic landscape of drugs targeting the DNA damage response (DDR) is rapidly expanding; however, an urgent unmet need remains for validated predictive biomarkers of response. SLFN11 has emerged as a promising predictor of sensitivity to DNA-damaging chemotherapies, and recently, been associated with sensitivity to PARP inhibition. We discuss its use as a predictive biomarker of response for targeting the DDR.
Experimental study on granite acoustic emission and micro-fracture behavior with combined compression and shear loading: phenomenon and mechanism
Authors: Cao Yue , Xu Jinhai , Chen Liang , Wu Peng , Shaikh Faiz
Published: December 2020

One element that is essential to consider in underground mining engineering applications is the possibility of pillar failure, which can result in deadly geological disasters, including earthquakes and surface subsidence. Pillars are commonly present under an inclined state and are significantly dependent upon combined compression and shear loading. However, many scholars regard the pure uniaxial compression strength (UCS) of rock as the main evaluation index of pillar strength, which is inconsistent with the field practice. Hence, the present study developed a novel combined compression and shear test (C-CAST) system, which was applied in the investigative acoustic emission (AE) experiments to characterize the failure mechanism and micro-fracture behavior of granite specimens at different inclination angles. The experimental results presented the exponential decrease of UCS of inclined specimens with increase in the shear stress component. Changes in the inclination angle with a range of 0°–10° produced a splitting-shear failure fracture mode from the initial splitting failure. In comparison, an increase in the inclination angle from 10° to 20° produced a single shear failure fracture mode from the initial combined splitting-shear failure. The specimens exhibited nonlinearly reduced microcrack initiation (CI) and damage (CD) thresholds following an increase in the inclination angle, suggesting the dependence of the microcrack initiation and propagation on the shear stress component. The ratio of CI and CD thresholds to inclined UCS varies within a certain range, indicating that the ratio may be an inherent property of granite specimens and is not affected by external load conditions. Additionally, the rock fracture behavior was largely dependent upon the mechanism of shear stress component, as validated by the microcrack initiation and growth. Finally, a modified empirical formula for pillar strength is proposed to investigate the actual strength of inclined pillar. Results of a case study show that the modified formula can be better used to evaluate the stability of inclined pillars.
Salience-based object prioritization during active viewing of naturalistic scenes in young and older adults
Authors: Nuthmann Antje , Schütz Immo , Einhäuser Wolfgang
Published: December 2020

Whether fixation selection in real-world scenes is guided by image salience or by objects has been a matter of scientific debate. To contrast the two views, we compared effects of location-based and object-based visual salience in young and older (65 + years) adults. Generalized linear mixed models were used to assess the unique contribution of salience to fixation selection in scenes. When analysing fixation guidance without recurrence to objects, visual salience predicted whether image patches were fixated or not. This effect was reduced for the elderly, replicating an earlier finding. When using objects as the unit of analysis, we found that highly salient objects were more frequently selected for fixation than objects with low visual salience. Interestingly, this effect was larger for older adults. We also analysed where viewers fixate within objects, once they are selected. A preferred viewing location close to the centre of the object was found for both age groups. The results support the view that objects are important units of saccadic selection. Reconciling the salience view with the object view, we suggest that visual salience contributes to prioritization among objects. Moreover, the data point towards an increasing relevance of object-bound information with increasing age.
Exceptional in-plane and interfacial thermal transport in graphene/2D-SiC van der Waals heterostructures
Authors: Islam Md. Sherajul , Mia Imon , Ahammed Shihab , Stampfl Catherine , Park Jeongwon
Published: December 2020

Graphene based van der Waals heterostructures (vdWHs) have gained substantial interest recently due to their unique electrical and optical characteristics as well as unprecedented opportunities to explore new physics and revolutionary design of nanodevices. However, the heat conduction performance of these vdWHs holds a crucial role in deciding their functional efficiency. In-plane and out-of-plane thermal conduction phenomena in graphene/2D-SiC vdWHs were studied using reverse non-equilibrium molecular dynamics simulations and the transient pump-probe technique, respectively. At room temperature, we determined an in-plane thermal conductivity of ~ 1452 W/m-K for an infinite length graphene/2D-SiC vdWH, which is superior to any graphene based vdWHs reported yet. The out-of-plane thermal resistance of graphene → 2D-SiC and 2D-SiC → graphene was estimated to be 2.71 × 10−7 km2/W and 2.65 × 10−7 km2/W, respectively, implying the absence of the thermal rectification effect in the heterobilayer. The phonon-mediated both in-plane and out-of-plane heat transfer is clarified for this prospective heterobilayer. This study furthermore explored the impact of various interatomic potentials on the thermal conductivity of the heterobilayer. These findings are useful in explaining the heat conduction at the interfaces in graphene/2D-SiC vdWH and may provide a guideline for efficient design and regulation of their thermal characteristics.
Autonomous molecule generation using reinforcement learning and docking to develop potential novel inhibitors
Authors: Jeon Woosung , Kim Dongsup
Published: December 2020

We developed a computational method named Molecule Optimization by Reinforcement Learning and Docking (MORLD) that automatically generates and optimizes lead compounds by combining reinforcement learning and docking to develop predicted novel inhibitors. This model requires only a target protein structure and directly modifies ligand structures to obtain higher predicted binding affinity for the target protein without any other training data. Using MORLD, we were able to generate potential novel inhibitors against discoidin domain receptor 1 kinase (DDR1) in less than 2 days on a moderate computer. We also demonstrated MORLD’s ability to generate predicted novel agonists for the D4dopamine receptor (D4DR) from scratch without virtual screening on an ultra large compound library. The free web server is available athttp://morld.kaist.ac.kr.
Ecological niche partitioning in a fragmented landscape between two highly specialized avian flush-pursuit foragers in the Andean zone of sympatry
Authors: Jablonski Piotr G. , Borowiec Marta , Nowakowski Jacek J. , Stawarczyk Tadeusz
Published: December 2020

In the Andes, pairs of ecologically similar species are often separated by narrow elevational sympatry zones but the mechanisms mediating sympatry are not fully understood. Here, we describe niche partitioning within a sympatry zone in a fragmented Andean landscape between two closely related flush-pursue species: a high-elevation montane forest dweller, (Myioborus melanocephalus), and a mid-elevation montane forest dweller, (M. miniatus). As all flush-pursuers use very similar hunting techniques involving visual displays to flush and pursue insects in air, and benefit from being the “rare predators”, ecological sorting between species in sympatry zones should allow their co-existence. We found that both species occupied vegetation resembling their typical allopatric habitats: a mosaic of pastures, clearings, and shrubs with small proportion of high trees for M. melanocephalus, and dense high forests with high proportion of trees, lower irradiance and higher humidity for M. miniatus. M. melanocephalus often foraged in bushes and at lower heights, whereas M. miniatus often foraged in tree crowns. The two species differed relatively little in their foraging technique. These results demonstrate how ecological sorting permits species of divergent elevational distributions and habitats to successfully coexist in sympatric zones where habitat diversity allows both species to find their preferred habitat.
Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
Authors: Kavková M. , Šulcová M. , Dumková J. , Zahradníček O. , Kaiser J. , Tucker A. S. , Zikmund T. , Buchtová M.
Published: December 2020

Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in place on the labial side only. Pleurodont teeth are characterized by significantly asymmetrical development of the labial and lingual sides of the cervical loop, which later leads to uneven deposition of hard tissue. On the other hand, acrodont teeth found in lizards of the Acrodonta clade (i.e. agamas, chameleons) are symmetrically ankylosed to the jaw bone. Here, we have focused on the formation of the symmetrical acrodont dentition of the veiled chameleon (Chamaeleo calyptratus). Intriguingly, our results revealed distinct asymmetries in morphology of the labial and lingual sides of the cervical loop during early developmental stages, both at the gross and ultrastructural level, with specific patterns of cell proliferation and stem cell marker expression. Asymmetrical expression of ST14 was also observed, with a positive domain on the lingual side of the cervical loop overlapping with the SOX2 domain. In contrast, micro-CT analysis of hard tissues revealed that deposition of dentin and enamel was largely symmetrical at the mineralization stage, highlighting the difference between cervical loop morphology during early development and differentiation of odontoblasts throughout later odontogenesis. In conclusion, the early asymmetrical development of the enamel organ seems to be a plesiomorphic character for all squamate reptiles, while symmetrical and precisely orchestrated deposition of hard tissue during tooth formation in acrodont dentitions probably represents a novelty in the Acrodonta clade.
Two-year outcomes of the treat-and-extend regimen using aflibercept for treating diabetic macular oedema
Authors: Kim Yu Cheol , Shin Jae Pil , Pak Kang Yeun , Kim Hyun Woong , Sagong Min , Lee Sang Joon , Chung In Young , Park Sung Who , Lee Ji Eun
Published: December 2020

This study was performed to investigate the efficacy of the treat-and-extend regimen using aflibercept for treating diabetic macular oedema (DME). This prospective, multicentre, interventional, single-arm, 104-week clinical trial included 48 patients with DME visual impairment. The patients’ eyes received five consecutive intravitreal injections (2 mg aflibercept) every four weeks with two-week adjustments based on central subfield macular thickness (CSMT) changes. Injections were deferred when CSMT was stable. The number of injections, best-corrected visual acuity (BCVA), CSMT, and diabetic retinopathy severity scale scores were analysed. Compared to baseline, BCVA improved by + 9.1 letters at 52 weeks and was maintained with + 9.4-letter gain at 104 weeks (P < 0.001). Between baseline and 104 weeks, CSMT decreased from 489 to 298 μm (P < 0.001) and eyes with vision ≥ 20/40 increased from 17.4 to 43.5% (P = 0.007). The mean number of injections decreased from 8.5 in year one to 3.9 in year two. The injection interval was extended to ≥ 12 weeks in 56.5% of patients. The treat-and-extend regimen of aflibercept in DME showed 2-year efficacy comparable to that of fixed dosing regimens. The flexible dosing of this regimen reduced the number of injections in year two while maintaining efficacy.
Genes associated with cognitive performance in the Morris water maze: an RNA-seq study
Authors: Reshetnikov Vasiliy V. , Kisaretova Polina E. , Ershov Nikita I. , Shulyupova Anastasia S. , Oshchepkov Dmitry Yu. , Klimova Natalia V. , Ivanchihina Anna V. , Merkulova Tatiana I. , Bondar Natalia P.
Published: December 2020

Learning and memory are among higher-order cognitive functions that are based on numerous molecular processes including changes in the expression of genes. To identify genes associated with learning and memory formation, here, we used the RNA-seq (high-throughput mRNA sequencing) technology to compare hippocampal transcriptomes between mice with high and low Morris water maze (MWM) cognitive performance. We identified 88 differentially expressed genes (DEGs) and 24 differentially alternatively spliced transcripts between the high- and low-MWM-performance mice. Although the sets of DEGs and differentially alternatively spliced transcripts did not overlap, both were found to be enriched with genes related to the same type of biological processes: trans-synaptic signaling, cognition, and glutamatergic transmission. These findings were supported by the results of weighted-gene co-expression network analysis (WGCNA) revealing the enrichment of MWM-cognitive-performance-correlating gene modules with very similar Gene Ontology terms. High-MWM-performance mice manifested mostly higher expression of the genes associated with glutamatergic transmission and long-term potentiation implementation, which are processes necessary for memory acquisition and consolidation. In this set, there were genes participating in the regulation of trans-synaptic signaling, primarily AMPA receptor signaling (Nrn1, Nptx1, Homer3, Prkce, Napa, Camk2b, Syt7, and Nrgn) and calcium turnover (Hpca, Caln1, Orai2, Cpne4, and Cpne9). In high-MWM-performance mice, we also demonstrated significant upregulation of the “flip” splice variant of Gria1 and Gria2 transcripts encoding subunits of AMPA receptor. Altogether, our data helped to identify specific genes in the hippocampus that are associated with learning and long-term memory. We hypothesized that the differences in MWM cognitive performance between the mouse groups are linked with increased long-term potentiation, which is mainly mediated by increased glutamatergic transmission, primarily AMPA receptor signaling.
Acid resistance of Masson pine (Pinus massoniana Lamb.) families and their root morphology and physiological response to simulated acid deposition
Authors: Zhou Sijie , Zhang Min , Chen Shuzhan , Xu Wen , Zhu Liting , Gong Shurui , He Xiaoqin , Wang Ping
Published: December 2020

Pinus massoniana Lamb. is one of the most sensitive species to acid deposition among forest woody plants, but differences in acid resistance among pine families still exist. It is of great significance to study the differences in acid resistance of Masson pine families and to analyze the physiological regulation mechanism of their acid resistance. In this study, the 100-day-old seedlings of 16 Masson pine families were treated with the simulated acid rain (SAR) at different pH levels (5.6, 4.5, 3.5 and 2.5) for 100 days to investigate the plant morphology, chlorophyll content, and root physiological responses. Results showed that pine family No. 35 maintained the good morphology, high chlorophyll content and organic acids secretion, and low plasma membrane permeability exposed to SAR, while family No. 79 presented the opposite. SAR not only increased the root plasma membrane permeability, but also induced an exudation of organic acids from the pine roots, and the test parameters changed sharply when the SAR pH was lower than 4.5. The results indicated that Masson pine could resist to acidic environment (pH 4.5–5.6), and family No. 35 had the acid resistance while the family No. 79 was sensitive to acid stress. The acid resistance diversity of different pine families had close relation with the root physiological processes, including the root plasma membrane permeability and organic acids secretion. For the future research, the natural genetic variation of Masson pine in response to acid stress and its acid resistance mechanism should be further studied.
fNIRS-based functional connectivity estimation using semi-metric analysis to study decision making by nursing students and registered nurses
Authors: Chong Jie Sheng , Chan Yee Ling , Ebenezer Esther G. M. , Chen Hoi Yen , Kiguchi Masashi , Lu Cheng-Kai , Tang Tong Boon
Published: December 2020

This study aims to investigate the generalizability of the semi-metric analysis of the functional connectivity (FC) for functional near-infrared spectroscopy (fNIRS) by applying it to detect the dichotomy in differential FC under affective and neutral emotional states in nursing students and registered nurses during decision making. The proposed method employs wavelet transform coherence to construct FC networks and explores semi-metric analysis to extract network redundancy features, which has not been considered in conventional fNIRS-based FC analyses. The trials of the proposed method were performed on 19 nursing students and 19 registered nurses via a decision-making task under different emotional states induced by affective and neutral emotional stimuli. The cognitive activities were recorded using fNIRS, and the emotional stimuli were adopted from the International Affective Digitized Sound System (IADS). The induction of emotional effects was validated by heart rate variability (HRV) analysis. The experimental results by the proposed method showed significant difference (FDR-adjustedp = 0.004) in the nursing students’ cognitive FC network under the two different emotional conditions, and the semi-metric percentage (SMP) of the right prefrontal cortex (PFC) was found to be significantly higher than the left PFC (FDR-adjustedp = 0.036). The benchmark method (a typical weighted graph theory analysis) gave no significant results. In essence, the results support that the semi-metric analysis can be generalized and extended to fNIRS-based functional connectivity estimation.
Comparing the novel microstream and the traditional mainstream method of end-tidal CO2 monitoring with respect to PaCO2 as gold standard in intubated critically ill children
Authors: Duyu Muhterem , Bektas Anıl Dogan , Karakaya Zeynep , Bahar Meral , Gunalp Aybuke , Caglar Yasemin Mocan , Yersel Meryem Nihal , Bozkurt Ozlem
Published: December 2020

The objective of this study was to evaluate a novel microstream method by comparison with PaCO2 and the more standard mainstream capnometer in intubated pediatric patients. We hypothesized that the novel microstream method would superior compared to the traditional mainstream method in predicting PaCO2. This was a prospective single-center comparative study. The study was carried out on 174 subjects with a total of 1338 values for each method. Data were collected prospectively from mainstream and microstream capnometer simultaneously and compared with PaCO2 results. Although both mainstream PetCO2 (mainPetCO2) and microstream PetCO2 (microPetCO2) were moderately correlated (r = 0.63 and r = 0.68, respectively) with PaCO2 values, mainPetCO2 was in better agreement with PaCO2 in all subjects (bias ± precision values of 3.8 ± 8.9 and 7.3 ± 8.2 mmHg, respectively). In those with severe pulmonary disease, the mainPetCO2 and microPetCO2 methods were highly correlated with PaCO2 (r = 0.80 and r = 0.81, respectively); however, the biases of both methods increased (14.8 ± 9.1 mmHg and 16.2 ± 9.0 mmHg, respectively). In cases with increased physiologic dead space ventilation, the agreement levels of mainPetCO2 and microPetCO2 methods became distorted (bias ± precision values of 20.9 ± 11.2 and 25.0 ± 11.8 mm Hg, respectively) even though mainPetCO2 and microPetCO2 were highly correlated (r = 0.78 and r = 0.78, respectively). It was found that the novel microstream capnometer method for PetCO2 measurements provided no superiority to the traditional mainstream method. Both capnometer methods may be useful in predicting the trend of PaCO2 due to significant correlations with the gold standard measurement in cases with severe pulmonary disease or increased physiological dead space –despite reduced accuracy.
Dual-functional ultraviolet photodetector with graphene electrodes on AlGaN/GaN heterostructure
Authors: Pandit Bhishma , Schubert E. Fred , Cho Jaehee
Published: December 2020

A dual-functional ultraviolet (UV) photodetector with a large UV-to-visible rejection ratio is presented, in which interdigitated finger-type two-dimensional graphene electrodes are introduced to an AlGaN/GaN heterostructure. Two photocurrent generation mechanisms of photovoltaic and photoconductive dominances coexist in the device. The dominance of the mechanisms changes with the induced bias voltage. Below a threshold voltage, the device showed fairly low responsivities but fast response times, as well as a constant photocurrent against the induced bias. However, the opposite characteristics appeared with high bias voltage. Specifically, above the threshold voltage, the device showed high responsivities with additional gain, but slow rise and recovery times. For instance, the responsivity of 10.9 A/W was observed with the gain of 760 at the induced bias voltage of 5 V. This unique multifunctionality enabled by the combination of an AlGaN/GaN heterostructure with graphene electrodes facilitates the development of a single device that can achieve multiple purposes of photodetection.
Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients
Authors: Yim Younghee , Kim Sang Joon , Jung Seung Chai , Kim Ho Sung , Choi Choong Gon , Lee Jung Kyo , Lee Chong Sik , Lee Seung Hyun , Shim Woo Hyun , Cheong E.-N. , Park Seong-Cheol
Published: December 2020

We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional brain volumes were measured using automated brain volumetry (NeuroQuant). The Unified Parkinson Disease Rating Scale motor score quotient was used to assess changes in clinical outcome and compare the preoperative regional brain volume in patients categorized into the higher motor improvement and lower motor improvement groups based on changes in the postoperative scores. The study groups showed significant volume differences in multiple brain areas. In the higher motor improvement group, the anterior cingulate and right thalamus showed high volumes after false discovery rate (FDR) correction. In the lower motor improvement group, the left caudate, paracentral, right primary sensory and left primary motor cortex showed high volume, but no area showed high volumes after FDR correction. Our data suggest that the effectiveness of DBS in patients with PD may be affected by decreased brain volume in different areas, including the cingulate gyrus and thalamus. Preoperative volumetry could help predict outcomes in patients with PD undergoing DBS.
Monte Carlo approach to risks assessment of heavy metals at automobile spare part and recycling market in Ilorin, Nigeria
Authors: Orosun Muyiwa Michael , Adewuyi Abayomi Daniel , Salawu Naheem Banji , Isinkaye Matthew Omoniyi , Orosun Olugbenga Rapheal , Oniku Adetola Sunday
Published: December 2020

This study evaluates the sources and health risks associated with heavy metals in Ipata spare part market in Ilorin, Nigeria. Soil and water samples were collected within and outside the market for heavy metal (As, Pb, Mg, Mn, Cd, Cr, Cu, Zn, Fe and Ag) analysis using Atomic Absorption Spectrometry. The results indicate that all the heavy metals analyzed show higher concentration within the recycling market than the control location. The concentration of heavy metals at the market decreases with an increasing depth between 0 and 50 cm and appears to be stable below 50 cm of the soil depth. All the Hazard Indices (HI) estimated for the soil samples are less than one (< 1) which is the standard set by USEPA, whereas, the Hazard Index (HI) for the water samples within the station is greater than 1. The Incremental Lifetime Cancer Risk (ILCR) for soil samples ranged from level I to level V, while that of water samples ranged from level VI to Level VII based on Delphii method of classification. This shows that the main lifetime cancer risk occurs through the water exposure pathway. Similarly, according to the mean, P5% and P95% cumulative probability using the Monte Carlo simulation, the ILCR is above the acceptable range of 1.00E−6 and 1.00E−4. All the pollution indices reveal that the significant pollution at the park is more of anthropogenic than pedogenic and lithogenic. Therefore, the market is contributing immensely to environmental pollution which may lead to unforeseen danger to human health.
Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage
Authors: Okamoto Yoko , Akagi Tadamichi , Suda Kenji , Kameda Takanori , Miyake Masahiro , Ikeda Hanako Ohashi , Nakano Eri , Uji Akihito , Tsujikawa Akitaka
Published: December 2020

Glaucoma is a multifactorial optic neuropathy, possibly involving vascular dysfunction, leading to the death of retinal ganglion cells and their axons. Disc hemorrhage (DH) is known to be closely associated with the widening of retinal nerve fiber layer defect (NFLD); however, it has not been well elucidated how DH affects retinal microvasculature. We aimed to investigate the association between DH history and longitudinal changes in superficial retinal microvasculature in NFLD. We enrolled 15 glaucoma patients with DH history (32 glaucomatous NFLD locations, with or without DH history). NFLD-angle, superficial retinal vessel density (VD), and decreased superficial retinal microvasculature (deMv)-angle were assessed using optical coherence tomography angiography for at least three times over time. The mean follow-up period and OCT/OCTA scan interval were 21.3 ± 5.4 months (range, 12–28) and 6.8 ± 0.4 months (range, 2–18), respectively. Linear mixed-effects models showed that the presence of DH history was significantly associated with an additional NFLD-angle widening of 2.19 degree/year (P = 0.030), VD decrease of 1.88%/year (P = 0.015), and deMv-angle widening of 3.78 degree/year (P < 0.001). These changes were significantly correlated with each other (P < 0.001). Thus, the widening of NFLD was closely associated with deMv, and DH was associated with a subsequent decrease in superficial retinal microvasculature in NFLD.