bluuebunny/crossref_metadata_2025 huggingface dataset:
Case report: Acute cubital tunnel syndrome in a hemophiliac patient
Authors: Debkowska Monika P , Cotterell Ilvy H , Riley Aimee J
Published: January 2019

A 24-year-old right-hand dominant male with severe Hemophilia A presented with acute elbow pain, associated paresthesias, and weakness in the ulnar nerve distribution after upper body weight lifting. In the week prior, he missed three doses of Factor VIII replacement. After no improvement with conservative measures, he was taken to the operating room urgently for decompression and was noted to have a perineural hematoma in the cubital tunnel. At final follow-up, the patient reported complete resolution of symptoms. Acute cubital tunnel syndrome in hemophiliac patients that does not respond to medical treatment is best treated with surgical decompression using minimal dissection to prevent hematoma formation, preserve perineural membranous tissue, and avoid destabilizing the nerve.
Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
Authors: Lee Lisa Eunyoung , Chan Jillian K , Nevill Emilie , Soares Adam , Vavasour Irene M , MacMillan Erin L , Garren Hideki , Clayton David , Keegan B Mark , Tam Roger , Traboulsee Anthony L , Kolind Shannon H , Carruthers Robert L
Published: January 2019

Background

Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant.

Objective

To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants.

Methods

Case report.

Results

Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups.

Conclusion

Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter.
Utility of Intracardiac Echocardiography to Diagnose Infective Endocarditis
Authors: Yang Ying Chi , Aung Thein Tun , Khan Sarah , Wase Abdul
Published: January 2019

Infective endocarditis (IE) can lead to significant morbidity and mortality without appropriate treatment. Modified Duke Criteria are accepted by many professional societies to establish the diagnosis of IE, and cardiac imaging is one of the major diagnostic criteria. Transesophageal echocardiography is an algorithmic escalation to diagnose IE when transthoracic echo does not appreciate a positive finding. In patients with contraindications to transesophageal echocardiography, cardiac magnetic resonance imaging, cardiac computed tomography (CT), cardiac CT angiography, and fluorodeoxyglucose positron emission tomography with CT or CT angiography may be alternative diagnostic tools. However, these imaging modalities have their own limitations such as local unavailability, the presence of non–magnetic resonance imaging compatible implants, or impaired renal function. Intracardiac echocardiography could be a considerable alternative under those circumstances.
Robotic Repair of a Congenital Isolated Cleft of Anterior Tricuspid Valve Leaflet
Authors: Hamandi Mohanad , Al-Azizi Karim , Crawford Alexander , Fan Joy , DiMaio J. Michael , Smith Robert L.
Published: January 2019

Congenital isolated tricuspid valve (TV) cleft in the anterior leaflet is a rare occurrence, while clefts of the mitral valve leaflets are more common and are usually associated with other congenital heart diseases. In this article, we report a case of TV regurgitation in a young adult female due to an isolated congenital cleft in the anterior TV leaflet, which was surgically repaired using a minimally invasive robotic approach.
The Bell Tolls for Homeopathy: Time for Change in the Training and Practice of North American Naturopathic Physicians
Authors: Nelson David H. , Perchaluk Jaclyn M. , Logan Alan C. , Katzman Martin A.
Published: January 2019

North American naturopathic medicine is a distinct form of practice that is woven into the larger fabric of integrative medicine; in a number of US states and Canadian provinces, naturopathic doctors enjoy a wide scope of practice, including the ability to make diagnoses, order tests, use medical technology, write prescription drugs, and perform minor surgeries. However, the basic premise of naturopathic medicine and its guiding principles—considering the whole person and supporting healthy lifestyle behaviors—is the unifying approach in clinical practice. In the 1970s, homeopathy—considered in many circles to be a hypothesis-driven, fringe form of alternative medicine—became embedded into the training and practice of North American naturopathic doctors. Since the earliest days of its theory (circa 1800), homeopathy has escaped, and continues to escape, biological plausibility; however, the persistence of this modality (and the insistence by both its consumers and practitioners that it provides benefit) speaks to the role of expectations, beliefs, values, agency, context effects, and the placebo-at-large. It is our contention that the progression of professional naturopathic medicine in the 21st century requires a major transition in how it approaches the subject of homeopathy. We propose that students should be encouraged to critically analyze the tenets of homeopathy, its lesser known history, and the idea of homeopathy as a biomedicine that simply awaits untold chemicophysical mechanisms. Furthermore, the modality of homeopathy should be incorporated into the larger context of placebo studies, narrative medicine, ethics, and psychotherapeutic techniques.
Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway
Authors: Liu Qing , Zhang Yanli , Liu Shuang , Liu Yanna , Yang Xiaohan , Liu Gang , Shimizu Takahiro , Ikenaka Kazuhiro , Fan Kai , Ma Jianmei
Published: January 2019

Background

Microglia-derived lysosomal cathepsins are important inflammatory mediators to trigger signaling pathways in inflammation-related cascades. Our previous study showed that the expression of cathepsin C (CatC) in the brain is induced predominantly in activated microglia in neuroinflammation. Moreover, CatC can induce chemokine production in brain inflammatory processes. In vitro studies further confirmed that CatC is secreted extracellularly from LPS-treated microglia. However, the mechanisms of CatC affecting neuroinflammatory responses are not known yet.

Methods

CatC over-expression (CatCOE) and knock-down (CatCKD) mice were treated with intraperitoneal and intracerebroventricular LPS injection. Morris water maze (MWM) test was used to assess the ability of learning and memory. Cytokine expression in vivo was detected by in situ hybridization, quantitative PCR, and ELISA. In vitro, microglia M1 polarization was determined by quantitative PCR. Intracellular Ca2+ concentration was determined by flow cytometry, and the expression of NR2B, PKC, p38, IkBα, and p65 was determined by western blotting.

Results

The LPS-treated CatCOE mice exhibited significantly increased escape latency compared with similarly treated wild-type or CatCKD mice. The highest levels of TNF-α, IL-1β, and other M1 markers (IL-6, CD86, CD16, and CD32) were found in the brain or serum of LPS-treated CatCOE mice, and the lowest levels were detected in CatCKD mice. Similar results were found in LPS-treated microglia derived from CatC differentially expressing mice or in CatC-treated microglia from wild-type mice. Furthermore, the expression of NR2B mRNA, phosphorylation of NR2B, Ca2+ concentration, phosphorylation of PKC, p38, IκBα, and p65 were all increased in CatC-treated microglia, while addition of E-64 and MK-801 reversed the phosphorylation of above molecules.

Conclusion

The data suggest that CatC promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway. CatC may be one of key molecular targets for alleviating and controlling neuroinflammation in neurological diseases.
Adjunctive simvastatin for treatment-resistant depression: study protocol of a 12-week randomised controlled trial
Authors: Husain Muhammad I. , Chaudhry Imran B. , Khoso Ameer B. , Husain Mohammad Omair , Rahman Raza R. , Hamirani Munir M. , Hodsoll John , Carvalho Andre F. , Husain Nusrat , Young Allan H.
Published: January 2019

Background

A third of patients diagnosed with major depressive disorder (MDD) experience treatment-resistant depression (TRD). Relatively few pharmacological agents have established efficacy for TRD. Therefore, the evaluation of novel treatments for TRD is a pressing priority. Statins are pleiotropic agents and preclinical studies as well as preliminary clinical trials have suggested that these drugs may have antidepressant properties.

Aims

To report on a protocol for a 12-week, randomised, double-blind, placebo-controlled trial of add-on treatment with simvastatin for patients meeting DSM-5 criteria for MDD who have failed to respond to at least two adequate trials with approved antidepressants. The trial has been registered with Clinicaltrials.gov in (ClinicalTrials.gov identifier: NCT03435744).

Method

After screening and randomisation to the two parallel arms of the trial, 75 patients will receive simvastatin and 75 patients will receive placebo as adjuncts to treatment as usual. The primary outcome is change in Montgomery–Åsberg Depression Rating Scale scores from baseline to week 12 and secondary outcomes include changes in scores on the 24-item Hamilton Rating Scale for Depression, the Clinical Global Impression scale, the 7-item Generalized Anxiety Disorder scale and change in body mass index from baseline to week 12. Assessments will take place at screening, baseline, and weeks 2, 4, 8 and 12. Checklists for adverse effects will be undertaken at each visit. Simvastatin (20 mg) will be given once daily. Other secondary outcomes include C-reactive protein and plasma lipids measured at baseline and week 12.

Results

This trial will assess simvastatin's efficacy and tolerability as an add-on treatment option for patients with TRD and provide insights into its putative mechanisms of action.

Conclusions

As the first trial investigating the use of simvastatin as an augmentation strategy in patients with TRD, if the results indicate that adjuvant simvastatin is efficacious in reducing depressive symptoms, it will deliver immediate clinical benefit.

Declaration of interest

I.B.C. and N.H. have given lectures and advice to Eli Lilly, Bristol Myers Squibb, Lundbeck, Astra Zeneca and Janssen pharmaceuticals for which they or their employing institution have been reimbursed. R.R. and M.M.H. have received educational grants and support for academic meetings from Pfizer, Roche, Novartis and Nabiqasim. A.H.Y. has been commissioned to provide lectures and advice to all major pharmaceutical companies with drugs used in affective and related disorders. A.H.Y. has undertaken investigator-initiated studies from Astra Zeneca, Eli Lilly, Lundbeck and Wyeth. None of the companies have a financial interest in this research.
National Survey of Oncologists at National Cancer Institute–Designated Comprehensive Cancer Centers: Attitudes, Knowledge, and Practice Behaviors About LGBTQ Patients With Cancer
Authors: Schabath Matthew B. , Blackburn Catherine A. , Sutter Megan E. , Kanetsky Peter A. , Vadaparampil Susan T. , Simmons Vani N. , Sanchez Julian A. , Sutton Steven K. , Quinn Gwendolyn P.
Published: January 2019

PURPOSE

To identify potential gaps in attitudes, knowledge, and institutional practices toward lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) patients, a national survey of oncologists at National Cancer Institute–Designated Comprehensive Cancer Centers was conducted to measure these attributes related to LGBTQ patients and desire for future training and education.

METHODS

A random sample of 450 oncologists from 45 cancer centers was selected from the American Medical Association’s Physician Masterfile to complete a survey measuring attitudes and knowledge about LGBTQ health and institutional practices. Results were quantified using descriptive and stratified analyses and by a novel attitude summary measure.

RESULTS

Of the 149 respondents, there was high agreement (65.8%) regarding the importance of knowing the gender identity of patients, which was contrasted by low agreement (39.6%) regarding the importance of knowing sexual orientation. There was high interest in receiving education regarding the unique health needs of LGBTQ patients (70.4%), and knowledge questions yielded high percentages of “neutral” and “do not know or prefer not to answer” responses. After completing the survey, there was a significant decrease ( P < .001) in confidence in knowledge of health needs for LGB (53.1% agreed they were confident during survey assessment v 38.9% postsurvey) and transgender patients (36.9% v 19.5% postsurvey). Stratified analyses revealed some but limited influence on attitudes and knowledge by having LGBTQ friends and/or family members, political affiliation, oncology specialty, years since graduation, and respondents’ region of the country.

CONCLUSION

This was the first nationwide study, to our knowledge, of oncologists assessing attitudes, knowledge, and institutional practices of LGBTQ patients with cancer. Overall, there was limited knowledge about LGBTQ health and cancer needs but a high interest in receiving education regarding this community.
Pain Management for Ambulatory Arthroscopic Anterior Cruciate Ligament Reconstruction: Evidence-Based Recommendations From the Society for Ambulatory Anesthesia
Authors: Abdallah Faraj W. , Brull Richard , Joshi Girish P. ,   on behalf of the Society for Ambulatory Anesthesia (SAMBA)
Published: January 2019

Ambulatory arthroscopic anterior cruciate ligament reconstruction is associated with moderate pain, even when nonopioid oral analgesics such as acetaminophen and nonsteroidal anti-inflammatory drugs are used. Regional analgesia can supplement nonopioid oral analgesics and reduce postoperative opioid requirements, but the choice of regional analgesia technique for anterior cruciate ligament reconstruction remains controversial. Femoral nerve block, adductor canal block, and local instillation analgesia have all been proposed and are supported by some evidence from randomized controlled trials. Consequently, regional analgesia practice in patients undergoing anterior cruciate ligament reconstruction remains mixed. Published systematic reviews were used to identify the regional analgesia modality that would provide a balance between analgesic efficacy and associated potential risks in the setting of nonopioid multimodal analgesic strategies. Based on the evidence available, local instillation analgesia provides the best balance of analgesic efficacy and associated risks (strong recommendation, moderate level of evidence) when used as a component of multimodal analgesic technique in the first 24 hours after outpatient arthroscopic anterior cruciate ligament reconstruction. In the absence of local instillation analgesia, clinicians might use adductor canal block or femoral nerve block (weak recommendation, weak level of evidence). These recommendations have been endorsed by the Society of Ambulatory Anesthesia and approved by its board of directors.
Systematic Review and Meta-analysis: Sometimes Bigger Is Indeed Better
Authors: Vetter Thomas R.
Published: January 2019

Clinicians encounter an ever increasing and frequently overwhelming amount of information, even in a narrow scope or area of interest. Given this enormous amount of scientific information published every year, systematic reviews and meta-analyses have become indispensable methods for the evaluation of medical treatments and the delivery of evidence-based best practice. The present basic statistical tutorial thus focuses on the fundamentals of a systematic review and meta-analysis, against the backdrop of practicing evidence-based medicine. Even if properly performed, a single study is no more than tentative evidence, which needs to be confirmed by additional, independent research. A systematic review summarizes the existing, published research on a particular topic, in a well-described, methodical, rigorous, and reproducible (hence “systematic”) manner. A systematic review typically includes a greater range of patients than any single study, thus strengthening the external validity or generalizability of its findings and the utility to the clinician seeking to practice evidence-based medicine. A systematic review often forms the basis for a concomitant meta-analysis, in which the results from the identified series of separate studies are aggregated and statistical pooling is performed. This allows for a single best estimate of the effect or association. A conjoint systematic review and meta-analysis can provide an estimate of therapeutic efficacy, prognosis, or diagnostic test accuracy. By aggregating and pooling the data derived from a systemic review, a well-done meta-analysis essentially increases the precision and the certainty of the statistical inference. The resulting single best estimate of effect or association facilitates clinical decision making and practicing evidence-based medicine. A well-designed systematic review and meta-analysis can provide valuable information for researchers, policymakers, and clinicians. However, there are many critical caveats in performing and interpreting them, and thus, like the individual research studies on which they are based, there are many ways in which meta-analyses can yield misleading information. Creators, reviewers, and consumers alike of systematic reviews and meta-analyses would thus be well-served to observe and mitigate their associated caveats and potential pitfalls.
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange for Deep Sedation in a Lung Transplant Candidate With Severe Cystic Fibrosis: A Case Report
Authors: You-Ten Kong E. , Zasso Fabricio B.
Published: January 2019

Transnasal humidified rapid-insufflation ventilatory exchange is a recently described technique for safer management of difficult airways and a novel ventilation technique under anesthesia. Its full potential in patient safety and benefits are still being investigated. We describe the use of transnasal humidified rapid-insufflation ventilatory exchange for deep sedation during dental extractions in a patient with severe cystic fibrosis as a precondition for lung transplantation. Patient wanted to have the procedure under general anesthesia with intubation due to extreme anxiety. However, we advocated deep IV sedation with transnasal humidified rapid-insufflation ventilatory exchange. Oxygenation was maintained without airway obstruction and pulmonary complications during the entire procedure of 110 minutes.
Wnt produced by stretched roof-plate cells is required for the promotion of cell proliferation around the central canal of the spinal cord
Authors: Shinozuka Takuma , Takada Ritsuko , Yoshida Shosei , Yonemura Shigenobu , Takada Shinji
Published: January 2019

Cell morphology changes dynamically during embryogenesis, and these changes create new interactions with surrounding cells, some of which are presumably mediated by intercellular signaling. However, the effects of morphological changes on intercellular signaling remain to be fully elucidated. In this study, we examined the effect of morphological changes in Wnt-producing cells on intercellular signaling in the spinal cord. After mid-gestation, roof-plate cells stretched along the dorsoventral axis in the mouse spinal cord, resulting in new contact at their tips with the ependymal cells that surround the central canal. Wnt1 and Wnt3a were produced by the stretched roof-plate cells and delivered to the cell process tip. Whereas Wnt signaling was activated in developing ependymal cells, Wnt activation in dorsal ependymal cells, which were close to the stretched roof plate, was significantly suppressed in embryos with roof plate-specific conditional knockout of Wls, which encodes a factor that is essential for Wnt secretion. Furthermore, proliferation of these cells was impaired in Wls conditional knockout mice during development and after induced spinal cord injury in adults. Therefore, morphological changes in Wnt-producing cells appear to generate new Wnt signal targets.
Integration between swim speed and mouth size evolves repeatedly in Trinidadian guppies and aligns with suction-feeding fishes
Authors: Kane Emily A. , Roeder Megan M. , DeRue McKenna L. , Ghalambor Cameron K.
Published: January 2019

Well-supported correlations between swim speed and mouth size during prey capture suggest the broad existence of an integrated relationship between locomotion and feeding in suction-feeding fishes. However, the influence of specialization on this relationship is unclear. We used divergent populations of Trinidadian guppies (Poecilia reticulata) to test whether integration during suction is generalizable to a non-suction specialist and whether intraspecific specialization of component systems affects their integration. Guppies from replicate high- and low-predation streams were recorded capturing wild-type zooplankton using suction. Alternative general linear models supported a positive correlation between swim speed and mouth size in derived low-predation populations, suggesting that the relationship can be extended in some cases. High-predation populations lack this integration, which may be the result of direct selection or constraints imposed by selection on locomotion. As guppies invade new habitats they may be evolving a new, integrated performance phenotype from a non-integrated ancestor.
The influence of added mass on muscle activation and contractile mechanics during submaximal and maximal countermovement jumping in humans
Authors: Wade Logan , Lichtwark Glen A. , Farris Dominic J.
Published: January 2019

Muscle contractile mechanics induced by the changing demands of human movement have the potential to influence our movement strategies. This study examined fascicle length changes of the triceps surae during jumping with added mass or increasing jump height to determine whether the chosen movement strategies were associated with relevant changes in muscle contractile properties. Sixteen participants jumped at sub-maximal and maximal intensities while total net work was matched via two distinct paradigms: (1) adding mass to the participant or (2) increasing jump height. Electromyography (EMG) and ultrasound analyses were performed to examine muscle activation, fascicle length and fascicle velocity changes of the triceps surae during jumping. Integrated EMG was significantly higher in the added mass paradigm with no difference in mean or maximal EMG, indicating that the muscle was activated for a significantly longer period of time but not activated to a greater intensity. Fascicle shortening velocity was slower with added mass compared than with increasing jump height; therefore, intrinsic force–velocity properties probably enabled increased force production. Improved fascicle contractile mechanics paired with a longer activation period probably produced a consistently larger fascicle force, enabling a greater impulse about the ankle joint. This may explain why previous research found that participants used an ankle-centred strategy for work production in the added mass paradigm and not in the jump height paradigm. The varied architecture of muscles within the lower limb may influence which muscles we choose to employ for work production under different task constraints.
HIIT Improves Left Ventricular Exercise Response in Adults with Type 2 Diabetes
Authors: WILSON GENEVIEVE A. , WILKINS GERARD T. , COTTER JIM D. , LAMBERTS REGIS R. , LAL SUDISH , BALDI JAMES C.
Published: January 2019

Type 2 diabetes is associated with reduced left ventricular reserve. It is unclear whether exercise training improves left ventricular function in people with type 2 diabetes.

Purpose

This study aimed to determine whether 3 months of high-intensity interval training (HIIT) improves left ventricular function during exercise in adults with type 2 diabetes.

Methods

Participants performed a V˙O2peak test and received a DXA scan and total blood volume measurement at baseline. Left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and left ventricular stroke volume (LVSV) were then measured at rest and during low- and moderate-intensity semirecumbent exercise in adults with type 2 diabetes before and after 3 months of HIIT (n = 11) or no training (control) (n = 5). The effects of HIIT were determined using repeated-measures ANOVA.

Results

HIIT increased V˙O2peak by approximately 15% (P < 0.002) but did not change body composition or total blood volume. LVESV decreased and LVEDV and LVSV increased from rest to moderate-intensity exercise in both groups at baseline (all P < 0.01). Three months of HIIT increased LVEDV (P = 0.008) and LVSV (P = 0.02) at all conditions, but there was no difference in controls (all P > 0.05). HIIT augmented the reduction in LVESV from rest to moderate-intensity exercise (P < 0.04), but LVESV was unchanged in controls. Increased LVEDV explained 51% of the change in LVSV after HIIT intervention. Mitral inflow parameters and mitral annular velocities were unaffected by HIIT (all P > 0.05).

Conclusions

HIIT training increased the LVSV response to exercise in adults with type 2 diabetes. These data suggest that HIIT can improve LV filling and emptying during exercise and reverse early cardiac consequences of type 2 diabetes.
Downhill Running Acutely Elicits Mitophagy in Rat Soleus Muscle
Authors: SHANG HUAYU , XIA ZHI , BAI SHENGCHAO , ZHANG HE , GU BOYA , WANG RUIYUAN
Published: January 2019

Purpose

This study aimed to investigate the effects of downhill treadmill running on mitochondrial structure/function and expression levels of mitophagy-related proteins in rat skeletal muscle.

Methods

A total of 48 male adult Sprague–Dawley rats were randomly divided into a control group (C, n = 8) and an exercise group (E, n = 40). Rats in the E group were exercised on a treadmill down a 16° decline at 16 m·min−1 for 90 min and were further divided into 0 h (E0), 12 h (E12), 24 h (E24), 48 h (E48), and 72 h (E72) postexercise subgroups (n = 8 each). At each time point, the soleus muscle was collected under full anesthesia. Mitochondrial ultrastructural changes in skeletal muscle were observed by a transmission electron microscope. The content of quantitative enzyme citrate synthase and the activities of mitochondrial respiratory chain complex II and complex IV were measured by enzyme-linked immunosorbent assay. Protein expressions of skeletal muscle cytochrome c oxidase subunit 1 (COX1), PTEN-induced putative kinase 1 (PINK1), and mitochondrial Parkin microtubule-associated protein 1 light chain 3 (LC3) were determined by Western blot. Mitochondrial colocalizations with Parkin, ubiquitin (Ub), p62/sequestosome 1 (p62), and LC3 were measured by the immunofluorescence double labeling technique.

Results

After downhill treadmill running, the skeletal muscle mitochondrial structure changed dramatically, and a large amount of mitophagosomes were observed; the citrate synthase content and complex II activity were significantly lower (P < 0.05), whereas complex IV activity and COX1 protein level remained unchanged; the expression levels of PINK1, Parkin, Ub, p62, and LC3 were significantly higher than those in the C group (P < 0.05 or P < 0.01).

Conclusion

A session of downhill treadmill running activated the PINK1/Parkin pathway and facilitated mitochondrial colocalizations with Ub, p62, and LC3, causing mitophagy and mitochondrial damage within the skeletal muscle.
Issues of Sukuk Ijarah
Authors: Nahar Faiza Husnayeni , Adha Mufti Alam , Wardani Dyah Titis Kusuma
Published: January 2019

Sukuk Ijarah is the most popular sukuk that increase in over the world since its start to introduce in 2001.  Not only Muslim country who issued this sukuk, so do Non-Muslim Country such as Germany, Japan and China. However, there is issue that come up due to the non-existence of Shariah compliance in this structure such as the requirement of sukuk doesn’t meet Maqasid Shari’ah perspective. Therefore, the aims of this paper to discuss some issue in sukuk Ijarah and give solution in order to develop Islamic capital market.
Analisis Votalitas Saham di Jakarta Islamic Index (JII) periode Januari 2015-Januari 2018
Authors: Tanjung Hendri , Martua Siregar Taufik Akbar
Published: January 2019

Penelitian ini bertujuan untuk melihat volatilitas Jakarta Islamic Index (JII) pada Jakarta Stock Exchange. Adapun teknik analisis yang digunakan pada penelitian ini adalah Generalized Autoregressive Conditional Heteroscedasticity (GARCH) dan Autoregressive Conditional Heteroscedasticity (ARCH). Kenormalan distribusi tingkat return pada JII dianalisis untuk menjawab apakah returnnya tersebar secara normal atau tidak. Dengan menggunakan data JII dari januari 2015 sampai dengan januari 2018 (724 data harian), ditemukan bahwa distribusi dari return JII tidak menyebar normal. Penelitian ini menyimpulkan bahwa return dari Jakarta Islamic Indeks sangat berfluktuasi.  Adapun implikasinya adalah akan diperoleh keuntungan yang sangat tinggi dan kerugian yang sangat besar pada satu hari.
Pengaruh Program Loyalitas terhadap Kesetiaan Konsumen pada Industri Halal di Yogyakarta
Authors: Adha Mufti Alam , Wahyudi Rofiul , Nahar Faiza Husnayeni
Published: January 2019

This study aims to examine the effect of perceived benefits of loyalty programs, which include: financial benefits, social benefits, hedonic benefits, symbolic benefits of loyalty programs in the Halal Industry. This study also examined the effect of loyalty programs on brand loyalty. This research was conducted using a quantitative approach, namely by conducting surveys, online with a sample of 200 respondents. The data in this study were processed using the Structural Equation Modeling (SEM) analysis version 21. The results showed that the financial benefit variables, social benefits, symbolic benefits had a significant positive effect on loyalty programs. While the hedonic variable on loyalty programs shows a negative relationship. This study also confirms the significant positive effect of the loyalty program on brand loyalty.
Mecanismos para potencialização da proteção do patrimônio cultural arquitetônico no município de belo Horizonte
Authors: Penido FONSECA RENATO Leal
Published: January 2019

Este estudo trata dos mecanismos para potencialização da preservação do patrimônio cultural arquitetônico no município de Belo Horizonte. Observou-se que, embora o instituto do tombamento seja utilizado para proteção dos bens culturais arquitetônicos, por vezes mostra-se ineficiente. Na busca por maior efetividade da proteção do patrimônio cultural, foram criados instrumentos para mitigação dos custos de manutenção das edificações e compensação financeira em razão da limitação do exercício do direito de propriedade. Além desses instrumentos, analisou-se o programa “Adote um Bem Cultural”, uma iniciativa de cooperação entre o setor privado e a Administração Pública municipal.
Políticas familiares. Una revisión crítica a partir de la singularidad de las experiencias de familia | Family policies: a critical review based on the uniqueness of family experiences
Authors: Krmpotic Claudia Sandra
Published: January 2019

Resumen – Se problematiza el campo de las políticas familiares desde un análisis microsocial, tomando como punto de partida la experiencia de familia. A través de un estudio de caso, se analizan tramos narrativos seleccionados obtenidos en entrevistas en profundidad, destacando las singularidades como las limitaciones de las intervenciones institucionales. Se evidencia el fracaso de las intervenciones públicas, incluso en lo que respecta a la institucionalización de la marginación. En la tensión entre lo impuesto y lo disponible resalta la capacidad de agencia para conseguir sobrellevar la pobreza y construir identidad.Palabras clave: estado de bienestar; modelización; experiencia de familia; significatividad; Argentina  Resumo – O campo das políticas familiares é problematizado a partir de uma análise microssocial, tomando como ponto de partida a experiência familiar. Por meio de um estudo de caso, são analisadas seções narrativas selecionadas, obtidas em entrevistas feitas em profundidade, destacando as singularidades como limitações das intervenções institucionais. O fracasso das intervenções públicas é evidente, mesmo no que diz respeito à institucionalização da marginalização. Na tensão entre o que é imposto e o que está disponível, destaca-se a capacidade de agência para superar a pobreza e construir uma identidade.Palavras-Chave: Estado de Bem-Estar Social; modelagem; experiência familiar; significancia; Argentina.  Abstract – The field of family policies is problematized from a microsocial analysis, taking as a starting point the family experience. Through a case study, selected narrative sections obtained in in-depth interviews are analyzed, highlighting singularities as limitations of institutional interventions. The failure of public interventions is evidenced, even about the institutionalization of marginalization. In the tension between what is imposed and what is available, the agency to overcome poverty and build identity stands out.Keywords: welfare state; modeling; family experience; significance; Argentina.
Famílias e assistência social: reflexões sobre o BPC e o PBF | Families and social assistance: reflections on the Continued Payment Benefit (BPC) and the Bolsa Família (PBF) programs
Authors: Senna Mônica De Castro Maia , Costa Brenda Luanda Silva
Published: January 2019

Este artigo pretende contribuir para o debate em torno do trabalho com famílias na política de assistência social, a partir da análise de alguns elementos que circunscrevem a centralidade da família nas políticas e programas sociais brasileiros nos anos recentes, mais especificamente no âmbito do Programa Bolsa Família e do Benefício de Prestação Continuada. Tomando por base estudos e experiências concretas, abordamos algumas inflexões produzidas nos sistemas nacionais de proteção social nas últimas décadas, com destaque para o caso brasileiro. Enfatizamos alguns aspectos contraditórios presentes nas relações estabelecidas entre Estado e família forjadas a partir da constituição dessas duas modalidades de provisão da assistência social.Palavras-Chave: política social; assistência social; família; bolsa família; benefício de prestação continuada. Abstract – This article intends to contribute to the debate about the work with families in social assistance policy, from the analysis of some elements that circumscribe the centrality of family in Brazilian social policies and programs in recent years, specifically within the scope of the Bolsa Família and the Continued Payment Benefit programs. Based on studies and concrete experiences, we have approached some inflections produced in national social protection systems in the last decades, focusing on the Brazilian case. We emphasize some contradictory aspects present in the relations established between state and family forged from the constitution of these two modalities of provision of social assistance.Keywords: social policy; social assistance; family; Bolsa Família; Continued Payment Benefits.
Conciliação nos Juizados Especiais Cíveis e acesso a justiça em Montes Claros
Authors: Dias Beatriz Ferreira , Veloso Cynara Silde Mesquita , Gabrich Lara Maia Silva
Published: January 2019

O acesso à justiça é um direito fundamental que garante ao cidadão pleno acesso a um sistema jurídico no qual se possa reivindicar direitos e resolver litígios, produzindo resultados justos e igualitários. A pesquisa objetiva investigar a contribuição da conciliação nos Juizados Especiais de Montes Claros para o efetivo acesso à justiça. Utilizar-se-á o método quantitativo de cunho descritivo, com procedimento bibliográfico e documental na base de dados do Conselho Nacional de Justiça, do Tribunal de Justiça de Minas Gerias e na legislação pertinente. A conciliação, por meio da celeridade e baixo custo às partes, objetiva a promoção eficaz do acesso à justiça a todos os cidadãos, é realizada como uma etapa do procedimento judicial dos Juizados Especiais Cíveis nas demandas de menor complexidade e causas de menor valor pecuniário.  Para tanto, a conciliação prima pela informalidade, simplicidade, economia processual e celeridade para que atenda a todas as camadas da população de modo a ampliar o acesso à justiça e desafogar a demanda da justiça comum.  Concluiu-se que os Juizados Especiais ampliam o acesso a uma ordem jurídica justa por meio da conciliação, que possibilita a resolução dos conflitos de sua competência de modo adequado, simples, célere e eficaz.
Olvasási stratégiák vizsgálata angol nyelvű szövegértési feladatokban 10-14 éves nyelvtanulók körében
Authors: Magyar Andrea , Habók Anita
Published: January 2019

Tanulmányunk célja egy összegzés nyújtása az idegen nyelvi olvasási elméletekről és modellekről, az idegen nyelvi olvasási stratégiák csoportosításairól, valamint a kapcsolódó empirikus vizsgálatunk eredményeiről. A tanulmányban az általános iskola felső tagozatát érintő pilotmérés eredményeit mutatjuk be, amelynek célja azoknak az olvasási és szövegértési stratégiáknak a feltérképezése volt, amelyek a leginkább jellemzik a vizsgált korosztályt. A vizsgálat kiterjedt a nyelvi stratégiák olvasás teszten nyújtott teljesítménnyel és különböző háttérváltozókkal való összefüggéseinek meghatározására, valamint a jól és kevésbé jól teljesítő tanulók nyelvi stratégiái közötti különbségek felderítését is célozta. A vizsgálatban a tanulók idegen nyelvi szintjének meghatározása egy A1 szintű validált olvasási részteszttel történt, az olvasási stratégiák beazonosítása pedig Cohen és Oxford (2002) olvasási stratégákra vonatkozó kérdőíve segítségével. A stratégiahasználatra vonatkozóan az állapítható meg, hogy az 5-6. évfolyamos tanulók körében még nem különülnek el tudatosan a stratégiahasználat, ez inkább a magasabb évfolyamokra jellemző. Az előzetes tudás jelentősen meghatározza a stratégiahasználatot, mely szintén a 7-8. évfolyamokon mutatható ki szignifikáns mértékben; az olvasás teszten magasabban teljesítő tanulók szignifikánsan gyakrabban használják stratégiáikat. A stratégiahasználatra és az idegen nyelvi eredményekre az attitűd van a legjelentősebb hatással. Eredményeink összecsengenek a nemzetközi kutatások eredményeivel, vagyis bizonyos nyelvi szint elérése a feltétele annak, hogy a tanulók hatékonyan tudják használni az olvasási és szövegértési stratégiáikat. Ezért főleg a magasabb évfolyamokon lenne indokolt stratégiatréningek beiktatása az idegen nyelvi oktatási-nevelési folyamatba.
Differential diagnosis of adrenal gland tumor: rare case report
Authors: Volkova Natalia I. , Ganenko Liliya A. , Mazhuhin Vladimir Y. , Shevchenko Aleksej N.
Published: January 2019

With the advent of high-resolution research methods (CT, MRI), randomly detectable formations in the adrenal glands became a clinical problem. The incidence of incidental adrenal glands varies between studies. So, according to the latest data, IN is detected in about 4-5% of patients who underwent radiological imaging. A clinical observation of a 39-year-old patient with complaints of persistent increase in blood pressure is presented. In the course of a routine ultrasound of the kidneys, the formation of a left adrenal gland was revealed. According to the data of the subsequent examination (adrenal SCT with contrast, determination of the hormonal profile), adrenocortical cancer, a glucocorticoid producing, was diagnosed. The patient underwent surgical treatment in the volume of left laparoscopic adrenalectomy. However, according to the results of a postoperative histological and immunohistochemical study, pheochromocytoma was diagnosed. The patient was discharged in satisfactory condition under the supervision of an endocrinologist and a surgeon. This clinical observation demonstrates that the “ideal” diagnostic approaches for differential diagnosis of IN have not yet been developed. Therefore, the continuation of research aimed at improving the diagnostic algorithm, which makes it possible to more accurately determine the morphological nature of education and its hormonal activity at the preoperative stage, is relevant both in scientific and in practical terms.
Der Beitrag des Fachinformationsdienstes Romanistik zur romanistischen Digitalkultur
Authors: Hornung Christoph , Rohden Jan
Published: January 2019

Christoph Hornung und Jan Rohden widmen sich in ihrem Beitrag neuen Anforderungen und Möglichkeiten des infrastrukturellen Hintergrunds geisteswissenschaftlicher Forschung: Die Digitalisierung betrifft nicht nur Wissenschaftlerinnen und Wissenschaftler, sondern auch zentrale Akteure der Wissenschaftspolitik und Forschungsförderung. So hat auch die DFG ihre Förderprogramme neu ausgerichtet und u.a. die seit 1949 bestehenden Sondersammelgebiete für die Wissenschaft durch die Fachinformationsdienste für die Wissenschaft (FIDs) abgelöst. Die damit verbundene Verschiebung des Sammelschwerpunkts von der möglichst vollständigen Sammlung fachspezifischer Printmedien zur bedarfsorientierten Informationsversorgung eröffnet neue Möglichkeiten der Literatur- und Informationsversorgung. Der vorliegende Beitrag illustriert diese exemplarisch anhand des Dienstleistungsspektrums des FID Romanistik. Neben einer Darstellung des Internetportals als zentraler Anlauf- und Schnittstelle zur Kommunikation mit der romanistischen Wissenschaftsgemeinschaft stehen dabei die beiden Dienstleistungsprojekte zum Open-Access-Publizieren und Forschungsdatenmanagement im Vordergrund.
Das Menschenrecht auf Gesundheit und die medizinische Versorgung irregulärer Migrant_innen
Authors: Kanalan Ibrahim , Krajewski Markus , Geks Hanna
Published: January 2019

Der Beitrag untersucht die besondere Vulnerabilität irregulärer Migrant_innen und zeigt die rechtlichen Grundlagen sowie tatsächlichen Gegebenheiten des Zugangs zu Leistungen der medizinischen Versorgung für irreguläre Migrant_innen auf. Dabei wird deutlich, dass bereits auf der Ebene des geltenden Rechts nur ein eingeschränkter Versorgungsumfang gewährt wird. Selbst dieser wird faktisch oft nicht wahrgenommen, da die Inanspruchnahme von den Betroffenen eigentlich zustehenden Leistungen negative aufenthaltsrechtliche Konsequenzen nach sich ziehen kann. Diese Rechts- und Sachlage wird an internationalen menschenrechtlichen Standards in der Konkretisierung durch die zuständigen Vertragsausschüsse der einschlägigen Übereinkommen und anderer Institutionen der Vereinten Nationen gemessen. Vor diesem Hintergrund zeigt sich, dass sich die menschenrechtlichen Verpflichtungen der Bundesrepublik nicht in der Ermöglichung eines theoretischen Zugangs irregulärer Migrant_innen zu Gesundheitsleistungen erschöpfen, sondern dass Deutschland verpflichtet ist, den Zugang auch tatsächlich zu ermöglichen.
Beberapa Faktor Risiko Kejadian Penyakit Ginjal Kronik (PGK) Stadium V pada Kelompok Usia Kurang dari 50 Tahun (Studi di RSUD dr.H.Soewondo Kendal dan RSUD dr.Adhyatma,MPH Semarang)
Authors: Ariyanto Ariyanto , Hadisaputro Suharyo , Lestariningsih Lestariningsih , Adi Mateus Sakundarno
Published: January 2019

Background: Chronic Kidney Disease (CKD) stage V is an end-stage chronic kidney disease  characterized by glomerular filtration rate less than 15 mL /min /1.73 m2 and require dialysis  therapy. The purpose of this study to prove risk factors the occurrence of CKD Vin the age  group of less than 50 years.   Method: This study was a mixed method, case-control studies design were inforced with  indepht interview. Total respondents were 124 (62 cases and 62 controls) that taken by  consecutive sampling. Research instrument was a questionnaire interview. Data analysis using  univariate, bivariate (chi-square) and multivariate (logistic regression).                     Result: The variables that proved to be a risk factor for CKD V in the age group of less than 50 years were supplement energy drink consumption > 4 times/week (p=0.038; 95%CI = 1.063-7.944; OR=2.905), smoking ≥ 10 ciggarets/day (p=0.011; 95%CI=1.384-11.920; OR=4.061), and herbal medicine consumption > 4 times/week (p=0.007; 95%CI=1.431-9.949; OR=3.773). Variables that not proved were the consumption of coffee, supplements of vitamin C, soft drinks, alcohol, and NSAIDs. Qualitative results stated that the respondents consumed energy drink supplements to increase their stamina, smoke because it has become a habit, and consume herbal medicines because seen more natural and cure the sciatica fastly.Conclusion: Risk factors for the occurrence of CKD V in the age group of less than 50 years were the supplement energy drink consumption> 4 times/week, smoking ≥ 10 ciggarets/day, and the consumption of herbal medicine> 4 times/week.
Ein Blick zum Nachbarn: die polnischen Bibliotheksgesetze und ihre Bedeutung für das polnische Bibliothekswesen
Authors: Bödecker Ursula
Published: January 2019

Polen blickt auf eine lange Tradition von Bibliotheksgesetzen zurück. Am 17. April 1946 wurde das Dekret über Bibliotheken und die Betreuung von Bibliotheksbeständen erlassen. Die Verabschiedung des Gesetzes über Bibliotheken vom 9. April 1968 und das derzeit geltende Gesetz über Bibliotheken vom 27. Juni 1997 sind weitere zeitliche Meilensteine. Die Entstehung der Bibliotheksgesetze ist mit der wechselvollen politischen Geschichte Polens eng verknüpft und weitgehend dem Engagement der polnischen Bibliothekare zu verdanken. Ein Bibliotheksgesetz ist für polnische Bibliothekare wichtig und unverzichtbar. Sie sind von den Möglichkeiten und Funktionen eines Bibliotheksgesetzes überzeugt und sehen diverse Chancen, die es für die Entwicklung des Bibliothekswesens bietet.
Hazard Ratio Estimators after Terminating Observation within Matched Pairs in Sibling and Propensity Score Matched Designs
Authors: Shinozaki Tomohiro , Mansournia Mohammad Ali
Published: January 2019

Similar to unmatched cohort studies, matched cohort studies may suffer from the censoring of events prior to the end of follow-up. Moreover, in some matched-pair cohort studies, observation time is prematurely terminated immediately after the follow-up of his/her matched member is completed by an event or censoring. Although the follow-up termination within matched pairs may or may not change the hazard ratio estimators, when and how the change occurs has not been clarified. We study the change in the estimates of the hazard ratio conditional on matched pairs and/or covariates by considering two types of matched-pair designs in cohort studies—sibling pair matching and propensity score matching—in which termination can be naturally considered. If all possible confounders are shared within the matched pairs, after termination, a wide range of hazard ratio estimators coincides with that obtained from a stratified Cox model. If unshared confounders should be adjusted for in the analysis, however, such coincidence is not observed. Simulation studies on sibling designs with unshared confounders suggested that the pair-stratified covariate-adjusted Cox model for the hazard ratio conditional on matched pairs and covariates is generally preferred, for which termination does not deteriorate the estimation. Conversely, the comparison between stratifying or not stratifying on pair is a more subtle issue in propensity score matching which targets a marginal or covariate-conditional hazard ratio. Based on simulation studies considering Cox models after matching based on estimated propensity scores, we discourage pair-stratified analysis and termination, particularly after data collection.