bluuebunny/crossref_metadata_2025 huggingface dataset:
Third-Order Neutral Delay Differential Equations with Mixed Nonlinearities: Almost Oscillation via Linearization Method and Arithmetic-Geometric Inequality
Authors: Sudha B. , Chatzarakis George E , Thandapani Ethiraju
Published: January 2025

In the present article, we create new sufficient conditions for the oscillatory and asymptotic behavior of solutions of the third-order nonlinear neutral delay differential equations with several super-linear and sub-linear terms. The results are obtained first by applying arithmetic-geometric mean inequality along with linearization method and then using comparison method as well as integral averaging technique. Finally, we show the importance and novelty of the main results by applying them to special cases of the studied equation.
Does the Digital Transformation of Manufacturing Improve Technological Innovation Capabilities of Enterprises—Empirical Evidence from China
Authors: Zang Jinxiang , Teruki Neilson , ONG SHARON YONG YEE , Wang Yan
Published: January 2025

Under the framework of new quality productivity, China emphasizes technological innovation, digital productivity, and green productivity to transform its manufacturing industry toward sustainability. This study empirically analyzes the impact of digital transformation using methods such as fixed effects models, instrumental variable approaches, propensity score matching with difference-in-differences, threshold regression, and quantile regression models. The findings reveal three key insights: (1) Digital transformation significantly enhances enterprise R&D output, R&D investment, and innovation efficiency by integrating digital technology with business processes to unlock innovation potential. (2) Cost stickiness plays a mediating role, as digital transformation reduces cost rigidity, freeing up resources for R&D investment. (3) The impact of digital transformation varies by corporate characteristics—larger, technology-intensive, less asset-intensive, and highly innovative firms show greater innovation gains. These results underscore the potential for Chinese manufacturing firms to adopt digital transformation as a strategy to shift away from extensive development, minimize resource use, and reduce environmental impact, thus achieving green productivity and sustainable growth. The study offers practical implications: Enterprises should actively pursue digital transformation by adopting advanced technologies and optimizing management. Attention to cost stickiness is essential for improving resource allocation and supporting R&D. Finally, firms should tailor digital strategies based on specific attributes, such as size and innovation intensity, to maximize the benefits of transformation.
Leveraging Digital Tools to Teach Entrepreneurship in the Classroom
Authors: Ali Syed-Rizwan , Hussain Javeed , Memon Muhammad Irfan , Mohatram Mohammad , Faraz Muhammad
Published: January 2025

Entrepreneurship education is a key engine to equip students with the high-level skills of creativity, problem-solving and strategic decision-making to navigate the constantly evolving global economy. The current study explores the role of digital tools in enhancing entrepreneurship training, focusing on the communicative platform, the collaborative platform, the simulation platform and the gamification platform. Tools such as Moodle, Capsim, Tableau and Kahoot make experiential learning possible, connecting the abstract with the concrete. Although digital tools have a mediated impact on learning outcomes related to entrepreneurship by promoting skill development, problems with digital skills, a lack of infrastructure and a culture of resistance to change are obstacles to achieving the full playing capacity of digital tools. The liberating possibility for the potential of future technology, especially AI and VR, for providing highly personalized and immersive education is demonstrated to be meaningful to the need for equitable access to resources and for having robust change management strategies. This research highlights the key and important role of digital technologies in entrepreneurial education reform and identifies the roadblocks to integrating those technologies effectively as well as suggests intervention strategies for better quality and access to education services in all SES levels.
Linear and Nonlinear Optical Properties of Non-Centrosymmetric Crystals of Substituted Aliphatic Secondary Amines
Authors: Ivanova Bojidarka
Published: January 2025

This paper like contributions to leading developments of nonlinear optical materials research aims for interdisciplinary readership and recognizing experimental and theoretical crystallographic, linear and nonlinear optical properties of non-centrosymmetric crystals of substituted aliphatic secondary amines as prospective templates for technological application. It deals with crystal structure of (2-piperazin-1-yl-ethyl)-nitrimine dihydrate (1) reported first, herein, that can be solved into both the P-1 and P1 space groups and 3,3,5-trimethyl-5-((nitroamino)methyl)cyclohexanaminium hydroxide (2) that could be solved into Pc and Pca21 ones. Crystals of (1) and (2) exhibit optical transparency within 190–1100 nm. Comparative analysis with data on novel crystal structure of (2-piperazin-1-yl-ethyl)-carbamic acid dihydrate (3) is also carried out. There is utilizes high resolution single crystal X-ray diffraction, high accuracy quantum chemical methods for in-depth understanding of relation among molecular and crystal structures, crystallographic packing, symmetry, linear optical and nonlinear optical properties. There are also used electronic and Fourier transform infrared vibration spectroscopy. Organic material research might provide evolutionary development in the face of innovative change of photonics technologies. The research effort, so far, has shown that they are mainly rigid crystals. However, future photonics technologies mandate organic flexible devices; thus, opening research avenue for implementation of organic photonics and electronics devices.
Evaluation of Fresh and Hardened Properties of Concrete Comprising E-Waste
Authors: Pasha Muhammad Shahrukh , Rasheed Sajid , Hussain Sharafat , Khan Jamshaid Ali , Khan Zarshaid Ali
Published: January 2025

Owing to rapid urbanization and population expansion, an increase in plastic utensils leads to an increase in plastic waste. Research in the domain of the recycling and repurposing of plastic waste in the construction industry offered a solution to decrease plastic waste as relief for environmental damage and protecting natural resources. This study is about replacing natural coarse aggregate in concrete with plastic coarse aggregate (PCA), which is made from electronic waste. Natural coarse aggregates (NCA) are replaced by PCA as 10%, 15%, and 20%. Rheological and mechanical properties i.e., workability, concrete density, compressive strength, and split tensile strength are investigated. The durability of concrete is assessed by water absorption, abrasion resistance, Sorptivity, Sulphuric attack resistance, and thermal conductivity. scanning electron microscopy is performed for the confirmation of durability claims. The analysis revealed that the use of produced PCA enhances the workability of concrete; nevertheless, the compressive and tensile strengths were reduced as 18.58% and 3.7%, respectively. PCA is treated with sand and silica fumes (SF) in order to attain targeted strength. It helped to reduce the negative effects of PCA on the strength properties of the concrete. PCA is concluded as a substitute for NCA having equivalent strength with enhanced performance of concrete.
Biosensors in the Meat Production Chain
Authors: Nastasijevic Ivan , Kundacina Ivana , Jaric Stefan , Pavlovic Zoran , Radovic Marko , Radonic Vasa
Published: January 2025

Biosensors are innovative and cost-effective analytical devices that integrate biological recognition elements (bioreceptors) with transducers to detect specific substances (biomolecules), providing high sensitivity and specificity for rapid and accurate Point-of-Care (POC) quantitative detection of selected biomolecules. In the meat production chain, their application has gained attention due to the increasing demand for enhanced food safety, quality assurance, food fraud detection and regulatory compliance demands. Biosensors can detect foodborne pathogens (Salmonella, Campylobacter, Shiga toxin-producing E. coli/STEC, L. monocytogenes), spoilage bacteria and indicators, contaminants (pesticides, dioxins, mycotoxins), antibiotics, antimicrobial resistance genes, hormones (growth promoters, stress hormones), metabolites (acute phase proteins as inflammation markers) at different modules along the meat chain, from livestock farming to packaging in farm-to-fork (F2F) continuum. By providing real-time data from the meat chain, biosensors enable early interventions, reducing health risks (foodborne outbreaks) associated with contaminated meat/meat products or substandard meat products. Recent advancements in micro and nanotechnology, microfluidics, and wireless communication have further enhanced the sensitivity, specificity, portability, and automation of biosensors, making them suitable for on-site, field applications. Integration of biosensors with blockchain and Internet of Things (IoT) systems allows acquired data integration and management, while integration with Artificial Intelligence (AI) and Machine Learning (ML) enables rapid data processing, analytics and input for risk assessment by competent authorities. This promotes transparency and traceability within the meat chain, fostering consumer trust and industry accountability. Despite biosensors’ promising potential, challenges such as scalability, reliability associated with the complexity of meat matrices and regulatory approval, are still the main challenges. This review provides a broad overview of the most relevant aspects of the current state-of-the-art biosensors` development, challenges and opportunities for prospective biosensors` application and its regular use in meat safety and quality monitoring and clarify further perspectives.
Asymmetric Effects of Fiscal Policy and Foreign Direct Investment Inflows on CO2 Emissions – an Application of Non-Linear Ardl
Authors: Nguyen Thanh Phuc , Duong Trang Thi-Thuy
Published: January 2025

Research on the impact of fiscal policy and foreign direct investment (FDI) on environmental quality has yielded conflicting results regarding their effects on carbon dioxide emissions. To further explore the asymmetric influences of these two critical factors on environmental quality, we employ a nonlinear ARDL approach to examine how fiscal policy (GOEX), FDI inflows, and other drivers of CO2 emissions, such as trade openness, financial development, and economic growth, affect environmental quality in Vietnam from 1990 to 2022. Our findings indicate that a positive shock in GOEX results in decreased emissions, whereas a negative shock in GOEX leads to increased emissions, challenging previous research suggesting that higher expenditures typically harm the environment. We also observe that positive changes in FDI result in higher CO2 emissions, whereas negative FDI shifts have no statistically significant impact. Additionally, our study revealed that trade openness improves environmental conditions, whereas economic growth and financial development contribute to increased CO2 emissions. The responses of CO2 emissions to the asymmetric effects of fiscal policy, FDI inflows, and other determinants in the short run last in the long run. These insights are valuable for policymakers to develop environmental sustainability strategies to mitigate climate change by addressing fiscal policies and other determinants of CO2 emissions.
EDUKASI KESEHATAN FISIK DAN MENTAL PADA REMAJA DI SMPN 2 AMLAPURA, KABUPATEN KARANGASEM, BALI
Authors: Rima Kusuma Ningrum  , Ekayani Ni Wayan Diana , Rajista I Gusti Ngurah Adi
Published: January 2025

Masa remaja merupakan masa perubahan dari anak-anak ke remaja, perubahan tersebut terjadi baik secara fisik, mental, emosi dan psikososial serta sistem reproduksi. Pada laki-laki dan perempuan batasan usia remaja pada kisaran umur 15-24 tahun belum menikah ini merupakan batasan umur yang telah ditetapkan oleh Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN). Dalam rentang usia tersebut terjadi perubahan secara fisik, bagi remaja laki-laki adanya perubahan suara, pertumbuhan jakun dan perubahan fisik pada perempuan dengan adanya pertumbuhan payudara serta perkembangan organ reproduksi secara maksimal. Di masa ini perlu adanya edukasi dan pendampingan terhadap remaja untuk tetap bisa menjaga kesehatan fisik maupun mental serta untuk menghindari terjadinya bullying. Tim pengabdian melakukan wawancara dengan kepala sekolah dan penyuluhan  ke sejumlah guru dan siswa di SMPN 2 Amlapura pada tanggal 29 Oktober 2022. Penyuluhan mengenai kesehatan fisik dan mental diikuti oleh 10 orang guru dan 32 siswa SMP. Kegiatan diawali dengan pemberian pre-test, pemaparan materi, tanya jawab dan post-test. Hasil kegiatan ini terjadi peningkatan sebesar 11.67 pada guru, sedangkan pada siswa terjadi peningkatan sebesar 14.75. Adanya peningkatan ini diharapkan guru dan siswa dapat menjaga kesehatan fisik maupun mental serta untuk menghindari terjadinya bullying.
ABSTRACT
Adolescence is a period of change from child to teenager; these changes occur both physically, mentally, emotionally, and psychosocially, as well as in the reproductive system. For men and women, the age limit for teenagers aged 15-24 years without marriage is the age limit set by the Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN). In this age range, physical changes occur; for teenage boys, there is a change in voice, the growth of the Adam's apple, and physical changes in women with breast growth and maximum development of reproductive organs. At this time, there is a need for education and assistance for teenagers to maintain their physical and mental health and to avoid bullying. The service team conducted interviews with school officials and counseled several teachers and students at SMPN 2 Amlapura on October 29, 2022. Counseling on physical and mental health was attended by 10 teachers and 32 junior high school students. The activity begins with giving a pre-test, presentation of the material, question and answer, and post-test. The results of this activity were an increase of 11.67 for teachers, while for students, there was an increase of 14.75. With this increase, it is hoped that teachers and students can maintain physical and mental health and avoid bullying.
Keywords: Teenager, reproductive and mental health, training and counseling, bullying.
PELATIHAN BUDIDAYA HIDROPONIK UNTUK MENINGKATKAN PRODUKTIVITAS LAHAN PADA KELOMPOK TANI HUTAN (KTH) LAMPERANGAN
Authors: Syamsia Syamsia , Rahim Iradhatullah , Anwar Andi Rahayu , Rohana Rohana , Safira Nanda , Amandira Selfi , Syahrir Muhammad , Aidin Ilhamsyah , Syafar Sukma
Published: January 2025

Kegiatan ini bertujuan untuk memberikan pengetahuan dan keterampilan kepada Kelompok Tani Hutan (KTH) Lamperangan tentang teknik bercocok tanam hidroponik sayuran untuk meningkatkan produktivitas lahan. Teknologi hidroponik yang diperkenalkan diharapakan dapat diterapkan oleh mitra sasaran dan menjadi sumber pendapatan bagi kelompok tani Lamperangan serta menjadi tempat eduwisata. Kegiatan ini dibagi dalam 3 tahapan yaitu: 1) Persiapan bahan dan peralatan; 2) Pelatihan dan penyuluhan; dan 3) Penerapan budidaya hidroponik sayuran. Hasil dari kegiatan pengabdian ini dapat disimpulkan bahwa anggota KTH Lamperangan memiliki minat yang cukup besar dalam menerapkan teknik budidaya hidroponik, peserta pelatihan sangat bersemangat saat praktek persemaian benih sayuran pada media rockwol, pemindahan bibit yang telah tumbuh ke instalasi serta pembuatan larutan nutrisi AB mix.
ABSTRACT
This activity aims to provide knowledge and skills to the Lamperangan Forest Farmers Group (KTH) regarding hydroponic vegetable farming techniques to increase land productivity. It is hoped that the hydroponic technology introduced can be implemented by target partners and become a source of income for Lamperangan farming groups as well as becoming an educational tourism destination. This activity is divided into 3 stages, namely: 1) preparation of materials and equipment; 2) training and counseling; 3) Application of hydroponic vegetable cultivation. The results of this service activity can be concluded that KTH Lamperangan members have quite a big interest in implementing hydroponic cultivation techniques, the training participants were very enthusiastic when practicing sowing vegetable seeds on rockwool media, transferring grown seeds to the installation and making AB mix nutrient solutions.
Keywords: Edutourism, wick hydroponics, productivity.
Activity concentrations of natural radioactivity and radiological dosimetry of virgin and agricultural soils in Kano State, Nigeria
Authors: Olabimtan Samuel Olugbenga , Chifu Ebenezer Ndikilar , Nasir Maharaz , Hafeez Hafeez Yusuf
Published: January 2025

Natural radiation exposure from varying number of radionuclides in the soil is a major source of radiation dose around the world. These radionuclides are taken up by plants and transferred to crops leading to their concentrations in foods/crops. Activity concentrations of natural radioactivity in uncultivated and agricultural soils were analyzed in six rice producing Local Government Areas (Bagwai, Bunkure, Dambatta, Garko, Kura and Wudil) of Kano State, Nigeria using gamma-ray Spectrometer with Sodium-Iodide Scintillation detector. The activity concentrations, in Bq.kg-1, of 40K, 238U and 232Th ranged from 262.03 – 848.64 (mean: 547.76 ± 27.16), 11.27 – 65.14 (mean: 31.60 ± 3.32) and BDL – 25.11 (mean: 8.75 ± 0.50) in virgin soils; and 249.01 – 1098.91 (mean: 509.51 ± 25.21), 0.97 – 59.92 (mean: 25.46 ± 2.73) and 3.28 – 24.13 (mean: 12.26 ± 0.70) in agricultural soils in the study areas. Concentrations of 40K and 238U in virgin soils were generally higher than their corresponding values recorded in agricultural soils but higher values of 232Th were obtained in agricultural soils. The mean values of Radium equivalent activity, 86.29 Bq.kg-1 (virgin soils), and 82.22 Bq.kg-1 (agricultural soils) were lower than the world average value: 370 Bq.kg-1. The average Hazard indices (external and internal) values of virgin soils (0.233, 0.3210) and agricultural soils (0.222, 0.291) were all less than unity, which is the maximum permissible limit. However, slightly higher values of Hazard indices were obtained in virgin soils. The mean absorbed dose rate (D), annual effective dose equivalent (AEDE) and excess lifetime cancer risk (ECLR) were: 42.73 nGyh-1, 0.0524 mSv.y-1 and 0.119 x 10-3, respectively for virgin soils and, 40.41 nGyh-1, 0.0500 mSv.y-1 and 0.113 x 10-3 respectively for agricultural soils. These estimated values for both virgin and agricultural soils are all less than the world average of 59.0 nGyh-1, 0.070 mSv.y-1 and 0.29 x 10-3. Slightly lower values of D, AEDE and ECLR in agricultural soils is as a result of continuous human activities due to farming practices.
A comparative study of numerical methods for estimating the relationship between cosmic energy and the expansion rate of the universe
Authors: Siagian Ruben Cornelius
Published: January 2025

This research aims to develop a numerical method that can accurately estimate the relationship between cosmic energy (E) and the expansion rate of the universe (H), taking into account the complex interactions between ordinary matter, dark matter, and dark energy. Numerical approaches based on Euler, Runge-Kutta, and Adams-Bashforth integration methods will be refined to evaluate the correlation. The limitation of this study is to a flat universe (k = 0 geometry), but it has the potential to be extended to other geometries. This effective numerical method can revolutionize cosmology by allowing accurate testing of cosmological theories and improving predictive capabilities. This study not only deepens our understanding of the behavior of the universe, but also opens up opportunities for further exploration. While there has been research on the Friedmann equation and the evolution of the universe, this study fills the gap by comparing three numerical methods, promising a more comprehensive and accurate analysis. This research demonstrates significant advances in cosmological methodology, with the potential to change the cosmological paradigm through efficient numerical approaches. By improving the understanding of cosmic energy and the expansion rate of the universe, this research not only contributes to the current knowledge of cosmology, but also paves the way for impactful follow-up research in this field.
Microwave-assisted roasting time on Ilmenite Bangka Belitung extraction using hydrometallurgical method
Authors: Mutakin Ikbalul , Suryana Risa , Septiani Eka Lutfi , Arutanti Osi , Widiyandari Hendri
Published: January 2025

Titanium Dioxide (TiO2) was extracted from Bangka Ilmenite through a hydrometallurgical process employing the microwave-assisted method using a 20% HCl solution. The highest crystallinity percentage in XRD result, reaching 75%, was achieved after a roasting duration of 25 minutes, with a corresponding crystallite size of  35.57 nm at the TiO2-Anatase phase's peak intensity of 25.24°. Analysis of the extracted ilmenite revealed alterations in its compound composition, notably an increase in TiO2 content. The most substantial increase in TiO2 content, rising to 69.7% from 33.76%, was observed after 25 minutes of roasting. UV–Vis spectroscopy revealed an energy band gap of 2.329 eV.
Robust adaptive fuzzy type-2 fast terminal sliding mode control of robot manipulators in attendance of actuator faults and payload variation
Authors: Rahali H. , Zeghlache S. , Cherif B. D. E. , Benyettou L. , Djerioui A.
Published: January 2025

Introduction. This study presents a robust control method for the path following problem of the PUMA560 robot. The technique is based on the Adaptive Fuzzy Type-2 Fast Terminal Sliding Mode Control (AFT2FTSMC) algorithm and is designed to handle actuator faults, uncertainties (such as payload change), and external disturbances. The aim of this study is to utilize the Fast Terminal Sliding Mode Control (FTSMC) approach in order to ensure effective compensation for faults and uncertainties, minimize tracking error, reduce the occurrence of chattering phenomena, and achieve rapid transient response. A novel adaptive fault tolerant Sliding Mode Control (SMC) approach is developed to address the challenges provided by uncertainties and actuator defects in real robotics tasks. Originality. The present work combined the AFT2FTSMC algorithm in order to give robust controllers for trajectory tracking of manipulator’s robot in presence parameters uncertainties, external disturbance, and faults. We use an adaptive fuzzy logic system to estimate the robot’s time-varying, nonlinear, and unfamiliar dynamics. A strong adaptive term is created to counteract actuator defects and approximation errors while also guaranteeing the convergence and stability of the entire robot control system. Novelty. The implemented controller effectively mitigates the chattering problem while maintaining the tracking precision and robustness of the system. The stability analysis has been conducted using the Lyapunov approach. Results. Numerical simulation and capability comparison with other control strategies show the effectiveness of the developed control algorithm. References 53, table 1, figures 8.
Chronic Patellar Tendon Rupture: Choice Between Two Allograft Reconstruction Techniques
Authors: Vosoughi Fardis , Sherafatvaziri Arash , Shayan-Moghadam Ramin , Babaei Nejad Erfan , Moezi Mehdi
Published: January 2025

Case:

In this article, we present 2 cases of neglected patellar tendon rupture. One was treated using an Achilles tendon allograft, and the other with a patellar tendon-bone allograft. Both methods allowed for early range of motion and resulted in good functional outcomes with a 1-year follow-up period.

Conclusion:

The choice of allograft for patellar tendon reconstruction is important. Although an Achilles allograft may be more readily available and have a high tensile strength, a bone-patellar tendon allograft may be a better choice when bone loss is present, and a high biological incorporation rate is desired.
Traumatic Anterior Dislocation of the Sacrococcygeal Joint Complicated by Defecatory Dysfunction
Authors: Nakayama Yoshifumi , Yonekawa Masahiro
Published: January 2025

Case:

We report a case of coccygeal dislocation complicated by defecatory dysfunction and discuss its treatment and mechanisms. A 58-year-old man was presented with coccygeal pain and defecatory dysfunction after sustaining an injury from a 1-m fall. Following diagnosis, a combined approach involving surgical treatment and physiotherapy was adopted, resulting in early symptom improvement and favorable long-term outcomes.

Conclusion:

Traumatic anterior dislocation of the coccyx is a rare but significant injury with no clear treatment guidelines. This report suggests the mechanisms underlying the association between defecatory dysfunction and coccygeal dislocation and underscores the therapeutic role of surgical intervention and physiotherapy.
Plan de negocios para comercialización digital de prendas para perros y gatos en Lima moderna
Authors:   , Chavez Goicochea Herles Edgar , Chuquichanca La Torre Raquel Leonor , Horna Chapoñan Romina Angela , Reyna Chavez Juana Adelaida
Published: January 2025

El informe a presentar está diseñado con la finalidad de establecer y operar una tienda digital que se especializa en la venta de ropa para perros y gatos en Lima Moderna. El proyecto se fundamenta en un análisis interno y externo a través de las herramientas estratégicas (matriz de Ansoff, Mefe, Mefi, Foda cruzado, cadena de valor, entre otros). En cuanto al estudio del mercado, se identificó el mercado objetivo y sus necesidades esenciales mediante el mapa de valor, así, el análisis del producto y su ampliación. Además, el análisis de la competencia brinda información de posicionamiento, cuota de mercado, precios, etc., donde se puede conocer y entender la situación del mercado y sus tendencias. En la sección de plan de marketing se desarrolló los objetivos de largo y corto plazo gracias a la identificación previa en el plan estratégico y estudio de mercado. Con ello, nacen las estrategias tradicionales y digitales para asegurar una operación eficiente. En el capítulo de plan de operaciones se destacaron los diagramas y flujos de proceso para conocer el detalle de la gestión de entradas y salidas, además, la capacidad de producción y cálculo de la demanda, espacio, equipos, entre otros puntos que determinan los pasos de inicio a fin de las operaciones. En el plan de recursos humanos es clave para detectar las personas indispensables para las actividades esenciales y se plasmó en el organigrama, así mismo, se identificó el mercado laboral, puestos a necesitar y funciones detalladas a través del perfil profesional. Por otro lado, en el área legal se conoció los requisitos legales para iniciar las actividades con la acreditación de la municipalidad y entidades relacionadas para laborar dentro de un marco normativo correcto...
Efectividad de la aspiración vs lavado peritoneal laparoscópico en pacientes intervenidos por peritonitis secundaria a apendicitis aguda complicada en el Hospital María Auxiliadora entre los años 2021 y 2024
Authors:   , Jorge Salas Jose Ernesto
Published: January 2025

Introducción: Si bien se sabe que la apendicetomía laparoscópica es el abordaje quirúrgico óptimo para la apendicitis aguda complicada, el debate surge con respecto al tratamiento de la peritonitis secundaria a la patología en cuestión. Debido a que el lavado peritoneal altera podría modificar los mecanismos de defensa y favorecería complicaciones como las colecciones residuales, el íleo postoperatorio y por ende una mayor estancia hospitalaria, no así la aspiración peritoneal, el tema continúa en discusión ya que los estudios no son concluyentes. Objetivo: Determinar la efectividad de la aspiración peritoneal comparada con el lavado peritoneal en pacientes intervenidos por peritonitis secundaria a apendicitis aguda. Métodos: Para ello se realizará un estudio observacional de tipo analítico de cohorte histórica, el cual incluirá 1034 historias clínicas distribuidas en dos grupos según el tipo de intervención. Se calculará el Riesgo relativo para comparar la incidencia de complicaciones, esto es infección de sitio operatorio e íleo postoperatorio, entre ambas técnicas quirúrgicas.
Control interno y gestión contable de la empresa Ecosem S.A., distrito Tinyahuarco, Pasco 2022
Authors:   , Cuentas Chavez Lila Sumico , Mendoza Tineo Rocio
Published: January 2025

El artículo científico abordó la influencia del control interno en la gestión contable de Ecosem S.A., una empresa ubicada en Tinyahuarco, Pasco. Adoptando un enfoque cuantitativo, clasificado como investigación básica, analizó los principios de gestión contable y control interno. El diseño no experimental y correlacional permitió explorar estas prácticas sin alterar variables directamente. Se halló una relación significativa, respaldada por la prueba Rho de Spearman (coeficiente = 0.546, p < 0.001). Esto resalta la importancia de implementar controles internos efectivos para una gestión contable precisa y eficiente, promoviendo decisiones financieras informadas. Los resultados son relevantes no solo para Ecosem S.A. sino también para otras empresas en Tinyahuarco y entornos similares, enfatizando la necesidad de un control interno sólido para una salud financiera y gestión contable eficaz.
Impacto del trabajo remoto en la productividad de los colaboradores de una empresa audiovisual, distrito de Miraflores (Lima-Perú), 2022
Authors:   , Fleming Tello Antonella Milagros , Ramos Valladolid Katherine Ysbel
Published: January 2025

En el entorno empresarial actual, el trabajo remoto y la productividad se han convertido en variables de vital importancia para garantizar la eficiencia, flexibilidad y logro de objetivos en las organizaciones. La pesquisa tuvo como propósito principal abordar la repercusión del trabajo remoto en la productividad en la empresa objeto de estudio. Con el ánimo de abordar esta problemática, se empleó un enfoque cuantitativo a través de un diseño no experimental transversal con características correlacionales-causales. La muestra consistió en un grupo de 16 colaboradores pertenecientes a la empresa audiovisual en cuestión. Los resultados obtenidos aportaron una valiosa perspectiva sobre la relación causal entre el trabajo remoto y la productividad, concluyendo que se constata una causalidad directa y positiva entre estas dos variables. La evidencia práctica de este resultado se respalda en el examen del coeficiente de Nagelkerke, cuyo valor de 0.989 brinda un soporte firme a la hipótesis alterna de que existe un efecto significativo entre los constructos considerados.
Comparación de la eficacia de las técnicas de bioadsorción y oxidación solar para la remoción de arsénico y plomo en el río Callazas-Tacna
Authors:   , Asti Benaducci Piero Francisco , Barrera Quea Martin Alejandro
Published: January 2025

Se analizaron y discutieron las eficiencias de dos tratamientos para la disminución de las concentraciones de arsénico y plomo en un cuerpo de agua, utilizando quince (15) litros de agua superficial del río Callazas, ubicado en la cuenca Locumba situado a su vez en el distrito y provincia de Candarave en la región Tacna. Se registraron valores de Arsénico (As) superiores a 1mg L-1, mientras que para Plomo (Pb) se obtuvieron valores inferiores a 0.05mg L-1. Se teorizó que los minerales volcánicos que contienen Fe influyeron en múltiples mecanismos los cuales frenan la elucidación de los resultados de la disección. Para el tratamiento de Oxidación Solar, se realizaron cuatro tratamientos con tres repeticiones cada uno utilizando ácido cítrico (C₆H₈O₇) y cloruro de hierro (Cl3Fe + 6H2O), obteniendo eficiencias de remoción de hasta un 17,4% para Arsénico (As) y 67.7% para Plomo (Pb). En cuanto a la Bioadsorción, se utilizaron dos (2) tipos de bioadsorbentes y los ensayos se separaron en dos (2) grupos siendo que en el primer grupo se evaluó la masa del bioadsorbente y en el segundo el tiempo de contacto, logrando eficiencias de remoción de hasta un 89% para Arsénico (As) y eficiencias de remoción negativas para Plomo (Pb). Finalmente, se recomienda que futuros ensayos sobre Biosorción se mantengan los valores de pH en un rango de cinco (5) a seis (6), para garantizar una eliminación óptima de Plomo (Pb), mientras que para la eliminación de Arsénico (As), el rango adecuado debe ser de tres (3) a cinco (5).
La interpretación como estrategia de la arquitectura vernácula en zonas de protección de patrimonio arqueológico: centro de interpretación del área arqueológica de Túcume
Authors:   , Torrejon Tremel César Adrian , Ventura Sandoval Manuel Jesus
Published: January 2025

El centro arqueológico de Túcume es uno de los más importantes del Perú, porque representa la identidad cultural de Lambayeque, Chimú y los incas, además, por su impresionante extensión territorial y sus 26 pirámides truncas hechas en adobe. La presente investigación es de tipo cualitativo y busca realzar e interpretar las características vernáculas de la arquitectura tradicional de Túcume, porque en la actualidad las edificaciones que se encuentran invadiendo el centro arqueológico de Túcume no representan las características vernáculas adecuadas para integrarse a la imagen urbana, donde la materialidad, las texturas, las formas, las tipologías arquitectónicas, las coberturas y las técnicas constructivas, permiten una identidad visual y espacial con el entorno. Para demostrar las características y criterios de la arquitectura vernácula de Túcume y Lambayeque se analizaron las dimensiones de cómo transferir la cultura y los rasgos tradicionales de la arquitectura a las nuevas construcciones; además, para reforzar los criterios vernáculos se analizó referentes arquitectónicos construidos que aporten a la visión de construir equipamientos que se integren al medio circundante; por último, se hizo una comparación de la normativa del Perú, México, Chile y España sobre los criterios básicos de la arquitectura vernácula que puedan aportar a las nuevas construcciones en centros arqueológicos y patrimoniales. En base a este análisis, se diseña el centro de interpretación entorno al centro arqueológico de Túcume utilizando criterios de la arquitectura vernácula, donde se emplean características que se integran al lugar, como la volumetría, el color, las texturas, la adaptación a la topografía, la adaptación al clima y las coberturas. De esta manera, el proyecto mantiene una identidad tipológica acorde a la memoria urbana y logra ser un referente para las nuevas construcciones en zonas arqueológicas y patrimoniales que resalten el valor histórico, cultural y urbanístico del lugar.
WITHDRAWN: A Multi-center Observational Cohort Study of Dialysis Patients’ Prognostic Factors: Evidence from Pakistan
Authors: Siddiqa Maryam , Shah Gulzar , Jones Jeffery
Published: January 2025

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
FABP3 methylation as a novel biomarker for the differentiation and classification of benign and malignant thyroid nodules
Authors: Huang Haixia , Yin Yifei , Li Hong , Li Junjie , Li Mengxia , Zhang Yi , Huang Xuandong , Zhang Yifen , Jiang Chenxia , Yang Rongxi
Published: January 2025

Background: Differentiation between benign and malignant thyroid nodules has been a challenge in clinical practice. We aim to explore a novel biomarker to determine the malignancy of thyroid nodules.
Materials and methods: In the discovery study, 32 tissue samples from benign thyroid nodule (BTN) and thyroid cancer (TC) patients were analyzed by Methylation 850K array and RNA-Sequencing. TC associated FABP3 methylation was further verified by mass spectrometry in two independent studies (221 BTN vs. 222 TC in Validation I and 191 BTN vs. 256 TC in Validation II). Logistic regression analysis and non-parametric tests were used for the analysis between groups.
Results: Altered and inversely correlated methylation and expression in FABP3 gene in TC was found in the discovery study (P = 2.90E-05 for the methylation and P = 0.040 for the expression), and verified in the two validation studies (P values range from 0.012 to 6.30E-10-12). FABP3 methylation could sufficiently differentiate TC from BTN (AUC = 0.77), and could be further improved when combined with the BRAFV600E mutations (AUC = 0.87). The association between FABP3 hypomethylation and TC was enhanced in women, in patients with younger age, with larger tumor size and with lower FT3. FABP3 methylation was varied in BTN and TC subtypes, with the highest level in adenoma and the lowest in anaplastic thyroid cancer.
Conclusion: Our study suggested that altered FABP3 methylation in tissue samples as a potential biomarker to distinguish malignant and benign thyroid nodules, and might be helpful for the pathological classification of TC.
Fall dormancy seasonally drives alfalfa–soil interactions by modulating soil nutrient status and microbial community on the Loess Plateau, China
Authors: Li Shengzhican , Zan Kanzhuo , Chen Yitong , Wang Kezheng , Qu Yang , Long Mingxiu , He Shubin
Published: January 2025

Aims
Fall dormancy (FD) in alfalfa (Medicago sativa L.) is a physiological adjustment strategy that determines forage yield, winter survival rates and spring regrowth. This study aimed to explore whether FD could drive alfalfa–soil interactions by modulating soil nutrient status and the microbial community.
Methods
We investigated the root characteristics, soil nutrients and bacterial and fungal communities of alfalfa cultivars (dormant (D), semidormant (SD), and nondormant (ND)) during the growing season and dormant season on the Loess Plateau, China.
Results
Our results indicated that the total nitrogen (TN), soil organic carbon (SOC) and total phosphorus (TP) contents tended to increase with increasing FD level in the dormant season. The opposite trend was generally observed for TN, sucrase (SUC) activity and protease (PRO) activity in the growing season. Furthermore, our results demonstrated that FD more readily influences soil fungal than bacterial communities; moreover, both bacterial and fungal diversity indices were lower in the dormant season than in the growing season. There were no obvious differences in the microbial co-occurrence network in the growing season, whereas in the dormant season, the percentage of positive interactions increased with increasing FD level, while that of negative correlations decreased.
Conclusions
Our results, based on the selection of alfalfa cultivars of different FD types, highlight the importance of the FD-driven rhizosphere effects, which further influences nutrient cycling and the soil microbial community, especially during the dormant season. This study provides valuable information for understanding complex FD-driven plant–soil interactions in alfalfa cultivation.
Pseudo-p-Value-Based Clumping Enhanced Proteome-wide Mendelian Randomization for Identifying Coronary Heart Disease-Associated Plasma Proteins
Authors: Hu Yue-Qing , Wang Yuquan , Cao Yunlong , Chen Dong , Shi Dapeng , Fu Liwan , Chen Anqi , Shen Siyuan
Published: January 2025

Mendelian randomization (MR) is a powerful tool for causal inference in epidemiology. However, the presence of weak instrumental variables (IVs) and pleiotropy can lead to biased causal effect estimates. To address these issues, we develop MR-GMM, a novel MR method based on a Gaussian Mixture Model. MR-GMM classifies IVs into four categories--invalid, valid, invalid&null, and null IVs--and models their effects using a two-dimensional spike-and-slab distribution. Simulation studies demonstrate the high efficiency and robustness of MR-GMM compared to existing methods. More importantly, we propose a pseudo-p-value-based linkage disequilibrium (LD) clumping procedure to address selection bias. This refined procedure is capable of enhancing the performance of MR-GMM as well as many existing MR methods in real-world scenarios. Applying MR-GMM in a large-scale proteome-wide MR study, we identify 45 coronary heart disease-associated plasma proteins. Subsequent network and enrichment analyses highlight the potential of these proteins as biomarkers for disease diagnosis and therapeutic development.
High performance relaxor ferroelectric textured ceramics for electrocaloric refrigeration
Authors: Li Fei , Li Xuexin , Li Jinglei , Li Yang , Liu Xuechen , Yang Shuai , Wu Jie , Hou Dingwei , Zhang Jinjing , Wu Haijun , Zhang Yang , Ding Xiangdong , Sun Jun , Zhang Shujun , hongliang Du
Published: January 2025

Relaxor ferroelectric ceramics have emerged as promising candidates for electrocaloric cooling systems due to their relatively higher heating and cooling capacities. However, simultaneously achieving high temperature changes (ΔT) and a wide operating temperature range remains a significant challenge, limiting their practical applications. This work proposes a synergistic strategy that involves precise compositional tuning of the BaTiO₃-xKNbO₃ system to customize the rhombohedral-to-cubic phase boundary around room temperature, coupled with engineering grain orientation of the ceramics. Based on this approach, a maximum ΔT of 3.9 K was achieved in <111>c-texture BaTiO₃-KNbO₃ ceramics, outperforming most environmentally friendly ceramics. Notably, the ΔT variation remained within ±10% across a temperature range of 30oC to 80oC, demonstrating a promising material for the design and application of electrocaloric cooling devices. This work provides new insights for the design of ceramics with optimized electrocaloric properties, offering significant potential for improving the efficiency and functionality of next-generation cooling technologies and devices.
Retrospective Analysis in Efficacy and Safety of Modified Stroke Protocol During the COVID-19 Epidemic: Real-World Experience from a Single Healthcare System
Authors: Wang Wei-Sheng , Jhou Hong-Jie , Wu Shey-Lin , Tung Chi-Hsiang , Sun Mu-Chien , Chen Yen-Chung
Published: January 2025

Introduction
The COVID-19 pandemic has posed significant challenges to healthcare systems and public health. We wonder whether modified stroke protocol (MSP) could provide timely treatment with comparable efficacy in acute stroke care.
Methods
Participants were victims of acute ischemic stroke who underwent endovascular therapy between January 2021 and July 2021. Modified stroke protocol (MSP) claims to conduct nasopharyngeal swab nucleic acid amplification test (NAAT) immediately while encountering a stroke patient suspected of having COVID-19. The efficacy outcome included good functional outcome (mRS score, 0 to 2 at 90 days). Safety outcomes were symptomatic intracranial hemorrhage within 36 hours and overall mortality at 3 months.
Results
Of the 61 patients with acute ischemic stroke who received endovascular therapy enrolled in our analysis, 17 patients were in the MSP group. Overall, there were comparable rates of good functional outcome between the MSP group (23.5%) and the usual care group (23.8%) (OR, 1.54; 95% CI, 0.25 to 9.39). Mortality at 90 days was equivalent: 29.4% in the MSP group and 26.2% in the usual care group (OR, 0.64; 95% CI, 0.10 to 4.17). The risk of symptomatic intracranial hemorrhage within 36 hours was 17.6% in the MSP group and 6.8% in the usual care group (OR, 0.16; 95% CI, 0.01 to 4.37).
Conclusions
Acute ischemic stroke patients in the MSP group had similar functional outcome with those in the usual care group, without significant increase in the rate of mortality at 3 months and symptomatic intracranial hemorrhage within 36 hours.
Effect of Gaza War on Mental Health of Different Egyptian Generations
Authors: Hassan Nadira Mansour , Hammad Rabab Ahmed , karem Amira Ahmed Abd El
Published: January 2025

Background: Exposure to unfavorable environmental circumstances including conflicts and wars increases people’s risk of experiencing mental health disturbances. Prevalence rates of anxiety, depression and stress disorders were two- to three-fold higher between people exposed to war or those interested in war news.
Objectives: to explore prevalence of depression, anxiety and stress among Tanta university students and their parent representing different Egyptian generations, identify associated factors and their effect on study/or work performance
Methods: A cross-sectional study was conducted to collect data from undergraduate medical students at Tanta University and their parent by using random cluster sampling technique. The study included 100 medical students and 200 parent. A self-administrated questionnaire was used which included sociodemographic data, DASS-21 (Depression, Anxiety Stress Scale) to measure levels of depression, anxiety and stress and the impact of war on studying /or work performance.
Results: Females were constituting 79.0% of students. All students and vast majority of fathers and mothers reported that they follow war news. Social media networks were the most frequently used source of information especially among students. Depression symptoms were expressed by 97.0% of students, 77.0% of mothers and 65.0% of fathers. Anxiety and stress were reported by about two thirds of students and 51% of mothers and 45.0% of fathers. Multivariant logistic regression analysis showed that the shared predictor that pointed to severe and extremely severe level of depression (p .004), Anxiety and stress (p<0.001) was frequently checkup of war news. On the other hand, young age (p<0.001) and female sex (p=0.023) were significant predictors for depression and urban residence was a significant predictor for severe and extremely severe level of anxiety.
Students’ desire to study and study hours were affected to some degree but among most parent, work performance was not affected.
Conclusion: Mental health problems were more prevalent among students followed by mothers and finally fathers. The students representing the younger generation were following war news frequently and were the worst affected generation. This study pointed that in countries outside wars, screening for different mental health problems, their determinants and predictors among different generations is crucial for identification of people whose condition requires specialized interventions
The expression of the tight junction protein and therapeutical target Claudin 18.2 is heterogeneously distributed within esophageal and gastric adenocarcinoma
Authors: Pak Svetlana , Simon Adrian Georg , Lyu Su Ir , Tolkach Yuri , Alakus Hakan , Zander Thomas , Buettner Reinhard , Bruns Christiane Josephine , Schroeder Wolfgang , Quaas Alexander
Published: January 2025

Claudin 18.2 (CLDN18.2) is a therapeutically relevant biomarker in esophageal (EAC) -and gastric adenocarcinoma (GAC). Little is known about its heterogeneity within the primary tumor and corresponding metastases and how many biopsies are needed to determine the true CLDN18.2 status of a tumor.
CLDN18.2 was assessed in 1,283 patients (822 EAC, 461 GAC), using the antibody clone 43-14A. Eight virtual endoscopic biopsies were taken from digitized whole tumor blocks.
204 of 822 EAC (24.8%) and 132 of 461 GAC (28,6%) were positive for CLDN18.2. In GAC, CLDN18.2 expression showed a trend towards more invasive growth (p = 0.02) and lymph node metastasis (p = 0.07) and was more often observed within the EBV-associated subtype (p = 0.01). When comparing the expression in one biopsy with the whole tissue section, the sensitivity for CLDN18.2 was low (58.8%). The sensitivity increased to a maximum of 76.5% with 6 and 8 biopsies. Discordant expression between primary tumor and corresponding local lymph node metastasis was observed in 18.5%.
This study highlights that CLDN18.2 is a heterogeneously expressed biomarker, within the tumor tissue as well as in primary tumor and corresponding lymph node metastasis. In case of CLN18.2-negative results the representativity of the biopsies must be critically assessed and a re-biopsy might be recommendable.