bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence for positive allosteric modulation of cognitive-enhancing effects of nicotine in healthy human subjects
Authors: Hahn Britta , Shrieves Megan E. , Olmstead Cory K. , Yuille Marie B. , Chiappelli Joshua J. , Pereira Edna F. R. , Albuquerque Edson X. , Fawcett William P.
Published: November 2019

Rationale

Cognitive benefits of nicotinic acetylcholine receptor (nAChR) agonists are well established but have generally been of small magnitude and uncertain clinical significance. A way of raising the effect size may be to facilitate agonist-induced responses by co-administering a nAChR positive allosteric modulator (PAM).

Objective

The aim was to test whether galantamine, a PAM at several nAChR subtypes, can potentiate the cognitive-enhancing effects of nicotine.

Methods

Twenty-six adult never-smokers were treated, in a double-blind counterbalanced sequence, with nicotine (7 mg/24 h, transdermally) and galantamine (4 mg, p.o.) combined, nicotine alone, galantamine alone, and double placebo. A low dose of galantamine was chosen to minimize acetylcholinesterase inhibition, which was verified in blood assays. In each condition, participants were tested with three cognitive tasks.

Results

Nicotine significantly improved reaction time (RT) and signal detection in a visuospatial attention task and the Rapid Visual Information Processing Task. Galantamine did not modulate these effects. A trend toward RT reduction by galantamine correlated with acetylcholinesterase inhibition. In a change detection task, there were no effects of nicotine or galantamine alone on accuracy or RT. However, both drugs combined acted synergistically to reduce RT. This effect was not associated with acetylcholinesterase inhibition.

Conclusions

A pattern consistent with allosteric potentiation of nicotine effects by galantamine was observed on one of six performance measures. This may reflect specific nAChR subtype involvement, or additional pharmacological actions of galantamine may have overshadowed similar interactions on other measures. The finding suggests that allosteric potentiation of nAChR agonist-induced cognitive benefits is possible in principle.
The Tutte Embedding of the Poisson–Voronoi Tessellation of the Brownian Disk Converges to $$\sqrt{8/3}$$-Liouville Quantum Gravity
Authors: Gwynne Ewain , Miller Jason , Sheffield Scott
Published: November 2019

Recent works have shown that an instance of a Brownian surface (such as the Brownian map or Brownian disk) a.s. has a canonical conformal structure under which it is equivalent to a $$\sqrt{8/3}$$8/3-Liouville quantum gravity (LQG) surface. In particular, Brownian motion on a Brownian surface is well-defined. The construction in these works is indirect, however, and leaves open a basic question: is Brownian motion on a Brownian surface the limit of simple random walk on increasingly fine discretizations of that surface, the way Brownian motion on $$\mathbb {R}^2$$R2 is the $$\epsilon \rightarrow 0$$ϵ→0 limit of simple random walk on $$\epsilon \mathbb {Z}^2$$ϵZ2? We answer this question affirmatively by showing that Brownian motion on a Brownian surface is (up to time change) the $$\lambda \rightarrow \infty $$λ→∞ limit of simple random walk on the Voronoi tessellation induced by a Poisson point process whose intensity is $$\lambda $$λ times the associated area measure. Among other things, this implies that as $$\lambda \rightarrow \infty $$λ→∞ the Tutte embedding (a.k.a. harmonic embedding) of the discretized Brownian disk converges to the canonical conformal embedding of the continuum Brownian disk, which in turn corresponds to $$\sqrt{8/3}$$8/3-LQG. Along the way, we obtain other independently interesting facts about conformal embeddings of Brownian surfaces, including information about the Euclidean shapes of embedded metric balls and Voronoi cells. For example, we derive moment estimates that imply, in a certain precise sense, that these shapes are unlikely to be very long and thin.
Critical Appraisal of the Impact of Oesophageal Stents in the Management of Oesophageal Anastomotic Leaks and Benign Oesophageal Perforations: An Updated Systematic Review
Authors: Kamarajah Sivesh K. , Bundred James , Spence Gary , Kennedy Andrew , Dasari Bobby V. M. , Griffiths Ewen A.
Published: November 2019

Introduction

Endoscopic placement of oesophageal stents may be used in benign oesophageal perforation and oesophageal anastomotic leakage to control sepsis and reduce mortality and morbidity by avoiding thoracotomy. This updated systematic review aimed to assess the safety and effectiveness of oesophageal stents in these two scenarios.

Methods

A systematic literature search of all published studies reporting use of metallic and plastic stents in the management of post‐operative anastomotic leaks, spontaneous and iatrogenic oesophageal perforations were identified. Primary outcomes were technical (deploying ≥ 1 stent to occlude site of leakage with no evidence of leakage of contrast within 24–48 h) and clinical success (complete healing of perforation or leakage by placement of single or multiple stents irrespective of whether the stent was left in situ or was removed). Secondary outcomes were stent migration, perforation and erosion, and mortality rates. Subgroup analysis was performed for plastic versus metallic stents and anastomotic leaks versus perforations separately.

Results

A total of 66 studies (n = 1752 patients) were included. Technical and clinical success rates were 96% and 87%, respectively. Plastic stents had significantly higher migration rates (24% vs 16%, p = 0.001) and repositioning (11% vs 3%, p < 0.001) and lower technical success (91% vs 95%, p = 0.032) than metallic stents. In patients with anastomotic leaks, plastic stents were associated with higher stent migration (26% vs 15%, p = 0.034), perforation (2% vs 0%, p = 0.013), repositioning (10% vs 0%, p < 0.001), and lower technical success (95% vs 100%, p = p = 0.002). In patients with perforations only, plastic stents were associated with significantly lower technical success (85% vs 99%, p < 0.001).

Conclusions

Covered metallic oesophageal stents appear to be more effective than plastic stents in the management of oesophageal perforation and anastomotic leakage. However, quality of evidence of generally poor and high‐quality randomised trial is needed to further evaluate best management option for oesophageal perforation and anastomotic leakage.
CT assessment of the quality of omentoplasty and its implications for perineal wound healing
Authors: Blok Robin D. , Sharabiany Sarah , Ferrett Colin G. , Hompes Roel , Tanis Pieter J. , Cunningham Christopher
Published: November 2019

Purpose

This study was designed to examine the impact of an omentoplasty and its quality on pelviperineal morbidity after abdominoperineal resection (APR) for rectal cancer.

Methods

This was a retrospective single-centre study of consecutive patients undergoing APR for primary or recurrent rectal cancer between 2000 and 2018. Quality of omentoplasty was categorised (sufficient vs insufficient) based on postoperative CT scans. Main study endpoints were perineal wound healing and perineal hernia.

Results

This study included 100 patients: 16 with a sufficient omentoplasty, 16 with an insufficient omentoplasty, and 68 without omentoplasty. Rate of pelviperineal complications within 30 days was 44%, 69% and 64% (P = 0.283), and delayed wound healing at 3 months was 19%, 54% and 27%, respectively (P = 0.109). Sufficient omentoplasty was not significantly associated with less delayed healing in multivariable analysis (OR 0.597; 95% CI 0.149–2.397). An insufficient omentoplasty demonstrated significantly higher rates of delayed healing at 6 months (46% vs 14%; P = 0.016) and chronic perineal sinus at 12 months (31% vs 3%; P = 0.008) compared with no omentoplasty.

Conclusion

This relatively small series suggest that even a sufficient omentoplasty, as determined by postoperative imaging, does not reduce pelviperineal morbidity after APR for rectal cancer. The methodology of CT-based assessment of an omentoplasty as well as the correlation with postoperative outcomes has to be validated in future studies.
From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
Authors: Colin Morvane , Dujardin Simon , Schraen-Maschke Susanna , Meno-Tetang Guy , Duyckaerts Charles , Courade Jean-Philippe , Buée Luc
Published: November 2019

The term “propagon” is used to define proteins that may transmit misfolding in vitro, in tissues or in organisms. Among propagons, misfolded tau is thought to be involved in the pathogenic mechanisms of various “tauopathies” that include Alzheimer's disease, progressive supranuclear palsy, and argyrophilic grain disease. Here, we review the available data in the literature and point out how the prion-like tau propagation has been extended from Alzheimer's disease to tauopathies. First, in Alzheimer’s disease, the progression of tau aggregation follows stereotypical anatomical stages which may be considered as spreading. The mechanisms of the propagation are now subject to intensive and controversial research. It has been shown that tau may be secreted in the interstitial fluid in an active manner as reflected by high and constant concentration of extracellular tau during Alzheimer’s pathology. Animal and cell models have been devised to mimic tau seeding and propagation, and despite their limitations, they have further supported to the prion-like propagation hypothesis. Finally, such new ways of thinking have led to different therapeutic strategies in anti-tau immunotherapy among tauopathies and have stimulated new clinical trials. However, it appears that the prion-like propagation hypothesis mainly relies on data obtained in Alzheimer’s disease. From this review, it appears that further studies are needed (1) to characterize extracellular tau species, (2) to find the right pathological tau species to target, (3) to follow in vivo tau pathology by brain imaging and biomarkers and (4) to interpret current clinical trial results aimed at reducing the progression of these pathologies. Such inputs will be essential to have a comprehensive view of these promising therapeutic strategies in tauopathies.
Logical negation mapped onto the brain
Authors: Grodzinsky Yosef , Deschamps Isabelle , Pieperhoff Peter , Iannilli Francesca , Agmon Galit , Loewenstein Yonatan , Amunts Katrin
Published: November 2019

High-level cognitive capacities that serve communication, reasoning, and calculation are essential for finding our way in the world. But whether and to what extent these complex behaviors share the same neuronal substrate are still unresolved questions. The present study separated the aspects of logic from language and numerosity—mental faculties whose distinctness has been debated for centuries—and identified a new cytoarchitectonic area as correlate for an operation involving logical negation. A novel experimental paradigm that was implemented here in an RT/fMRI study showed a single cluster of activity that pertains to logical negation. It was distinct from clusters that were activated by numerical comparison and from the traditional language regions. The localization of this cluster was described by a newly identified cytoarchitectonic area in the left anterior insula, ventro-medial to Broca’s region. We provide evidence for the congruence between the histologically and functionally defined regions on multiple measures. Its position in the left anterior insula suggests that it functions as a mediator between language and reasoning areas.
Experimental Investigation of the Permeability and Mechanical Behaviours of Chemically Corroded Limestone Under Different Unloading Conditions
Authors: Li Hao , Zhong Zuliang , Eshiet Kenneth Imo-Imo , Sheng Yong , Liu Xinrong , Yang Dongmin
Published: November 2019

This paper investigates the mechanical properties and permeability of chemically corroded rock during deep underground tunneling. Nuclear magnetic resonance tests are carried out to quantify the chemical damage of limestone samples at the microscopic scale. Coupled hydrostatic pressure-unloading tests at different unloading rates are also conducted on these chemically corroded limestone samples to investigate permeability changes and chemical effects on mechanical behaviours. Magnetic resonance imaging, T2 spectrum distribution and porosity of the samples are obtained, and the chemical micro damage is visualized and quantified. The relationship between permeability and mechanical behaviors of the rock under hydrochemical–mechanical coupled effects is investigated. The results show that the permeability development process of the chemical corroded samples can be divided into three stages: at the first stage, the permeability initially decreases, and the second stage starts at the inflection point of the permeability curve, from where the permeability begins to increase slightly. At the third stage, the permeability of the limestone increases dramatically until the sample is ruptured. Chemical corrosion and unloading rates have a combined and significant influence on the development of micro cracks in rocks, which is the root cause of the permeability changes. A stress-permeability model is proposed to describe the permeability and stresses in chemical-corroded limestone; this can be adopted for other sedimentary rocks.
Comparison of the geometry of the left ventricle outflow tract, the aortic root and the ascending aorta in patients with severe tricuspid aortic stenosis versus healthy controls
Authors: Nieznańska Małgorzata , Zatorska Karina , Stokłosa Patrycjusz , Ryś Małgorzata , Duchnowski Piotr , Szymański Piotr , Hryniewiecki Tomasz , Michałowska Ilona
Published: November 2019

The purpose of this study was to assess by multislice computed tomography (MSCT) imaging geometry of the ascending aorta, the aortic root, the aortic annulus and the left ventricle outflow tract (LVOT) in aortic stenosis (AS) patients, to compare aortic root morphology in patients with AS with healthy controls and to evaluate sex differences. Fifty patients with severe AS and 50 age- and gender-matched controls who underwent MSCT were included in the study. The dimensions of the LVOT, the aortic annulus, the aortic root, the ascending aorta, and the volume of the aortic root were retrospectively assessed and a comparison was made between patients with severe tricuspid AS and controls. Patients with tricuspid AS in comparison with controls had smaller dimensions of the sinus of Valsalva resulting in reduction of the aortic root volume, whereas the dimensions of the other structures were comparable. MSCT revealed larger annular, LVOT and the sinus of Valsalva dimensions and the aortic root volume in men than women. Men with AS differed from healthy men only in regard to the dimensions of the sinus of Valsalva, while women showed significant differences also in the LVOT, and the aortic annulus. MSCT showed accurately aortic root remodeling in tricuspid AS patients and indentified sex-dependent differences. Women with tricuspid AS differ from healthy women more than men did. A high degree of the variability in the aortic root dimensions requires further careful research.
Dynamics in higher education choice: weighing one’s multiple interests in light of available programmes
Authors: Vulperhorst Jonne Pieter , van der Rijst Roeland Matthijs , Akkerman Sanne Floor
Published: November 2019

Recent studies have shown that students’ interests are decisive in making a substantiated higher education choice, yet do not indicate how students decide which interests they aim to pursue. This study aimed to find the considerations students have when weighing interests and higher education programmes. Thematic analysis was applied to uncover considerations based on semi-structured interviews with 20 Dutch high-school seniors. Students weighed their interests from an interest-to-programme perspective (contrasting interests and deciding which is most important for their future) and from a programme-to-interest perspective (evaluating how possible programmes reconcile with one’s interests). By applying both perspectives simultaneously, students dynamically considered which programmes and interests they wished to pursue. These findings imply that higher education choice theory and studies should acknowledge that the programmes and interests students consider are dependent on the feed forward of the considered interests on programmes and the feed back of considered programmes on interests.
Register and Layout in Epistolary Judeo-Arabic
Authors: Wagner Esther-Miriam
Published: November 2019

Medieval letters from the Cairo Geniza can be broadly classified into private, official, or mercantile correspondence, and all use particular linguistic registers. Official correspondence, for example, shows abundant code switching into Hebrew and the employment of high-style versus lower-style prose. Mercantile letters actively avoid Hebrew and emulate supraconfessional Arabic writing standards. Private letters typically display more colloquial and less standardized forms than other genres and are more often written in crude handwriting. Among these private letters, we find one written by or for women that share common features of colloquiality and less standardization even when they are transcribed by male scribes. Linguistic registers are also influenced by the time and place in which they are written, and comparing Geniza letters from different areas and time periods exposes geographic and chronological characteristics. For example, North African letters tend to be linguistically more conservative, and Babylonian and Egyptian letters show differences in layout and style. Throughout the medieval period, orthographic, grammatical, lexical, and stylistic changes in the letters reflect social and economic evolution over time. The principal trend is a distinct move away from prescriptive Arabic linguistic norms from the late twelfth century on.
Impact of nanoparticle magnetization on the 3D formation of dual-phase Ni/NiO nanoparticle-based nanotrusses
Authors: Ekeroth Sebastian , Ikeda Shuga , Boyd Robert , Münger Peter , Shimizu Tetsuhide , Helmersson Ulf
Published: November 2019

Magnetic nanoparticles with average size 30 nm were utilized to build three-dimensional framework structures—nanotrusses. In dual-phase Ni/NiO nanoparticles, there is a strong correlation between the amount of magnetic Ni and the final size and shape of the nanotruss. As it decreases, the length of the individual nanowires within the trusses also decreases, caused by a higher degree of branching of the wires. The position and orientation of the non-magnetic material within the truss structure was also investigated for the different phase compositions. For lower concentrations of NiO phase, the electrically conducting Ni-wire framework is maintained through the preferential bonding between the Ni crystals. For larger concentrations of NiO phase, the Ni-wire framework is interrupted by the NiO. The ability to use nanoparticles that are only partly oxidized in the growth of nanotruss structures is of great importance. It opens the possibility for using not only magnetic metals such as pure Ni, Fe, and Co, but also to use dual-phase nanoparticles that can strongly increase the efficiency of e.g. catalytic electrodes and fuel cells.
Comparative life cycle assessment of car disc brake systems—case study results and method discussion about comparative LCAs
Authors: Gradin Katja Tasala , Åström Anna Hedlund
Published: November 2019

Purpose

Two life cycle assessment (LCA) studies comparing a new low-particulate-matter-emission disc brake and a reference disc brake were presented. The purpose was to identify the difference in potential environmental impacts due to a material change in the new disc brake parts. Additionally, the validity was investigated for the simplification method of omitting identical parts in comparative LCA. This was done by comparing the results between the simplified and the full LCA model.

Methods

The two disc brakes, new disc brake and reference disc brake, were assessed according to the LCA ISO standards. The ReCiPe 2016 Midpoint (hierarchist) impact assessment method was chosen. Simplifying a comparative LCA is possible, all identical parts can be omitted, and only the ones that differ need to be assessed. In this paper, this simplification was called comparative LCA with an omission of identical parts.

Results and discussion

The comparative impacts were analysed over seventeen impact categories. The new disc brake alternative used more resources during the manufacture of one disc compared to the reference disc brake alternative. The shorter life length of the reference disc demanded a higher number of spare part discs to fulfil the same functional unit, but this impact was reduced due to material recycling. The new disc brake impacts were connected primarily to the coating and secondly to the pad manufacture and materials. The validity of the simplification method was investigated by comparing the results of the two LCA models. The impact differences were identical independent of the LCA model, and the same significant impact categories could be identified. Hence, the purpose of the study could be fulfilled, and the simplification was valid.

Conclusions

Both LCA models, simplified and full, revealed that the new disc brake had limited environmental advantages. The omission of identical parts made it more challenging to determine if an impact was significant or insignificant. The simplification seemed to be reasonable.
The inner dimension of sustainability transformation: how sense of place and values can support sustainable place-shaping
Authors: Grenni Sara , Soini Katriina , Horlings Lummina Geertruida
Published: November 2019

Sense of place and values are concepts that have been defined in a multiplicity of ways by a variety of disciplines and seldom approached in combination within studies of place-based sustainability. In recent years, the debate on sustainability, and particularly on sustainability transformation, has started to recognise the central importance of the “inner dimension” in achieving sustainable futures. This brings to the fore individual and cultural immaterial aspects, such as values and sense of place. The aim of this article is to explore the role of sense of place and place values in the context of sustainable place-shaping and propose a framework to operationalise them in research. Three central questions guided and structured our work: (a) how can place-shaping contribute to sustainability transformations? (b) what is the role of the inner dimension of transformation in processes of sustainable place-shaping? (c) how to include the inner dimension—specifically sense of place and its underlying values—into place-shaping practice and discourse? Through the article, we argue that there is scope for a broader understanding of how sense of place contributes to sustainability transformations through place-shaping. The article ends with the introduction of an analytical tool for the study of sense of place and place values as potential drivers of place-based transformation. The conclusion of the article summarises the contribution of the inner dimension of place to place-shaping and, more in general, sustainability transformation.
The Dark Triad and BIS/BAS: a Meta-Analysis
Authors: Włodarska Katarzyna A. , Zyskowska Emilia , Terebus Martyna K. , Rogoza Radosław
Published: November 2019

Are there any temperamental predispositions to developing a dark personality traits? Within the current paper we address this question by investigating relations between the temperamental traits of the behavioural inhibition and approach systems (BIS and BAS, respectively) and the Dark Triad traits of personality. For this purpose, we conducted a meta-analysis of 18 studies with a total of 8911 participants. The results partially corroborated existing claims that the Dark Triad traits are a group of high-approach low-avoidance temperamental traits; however, the role of BAS seems to be more important. Among the Dark Triad traits, narcissism seems to be the most related to both the BIS and the BAS. Psychopathy in turn seems to be mostly related to the fun-seeking facet of the BAS. Finally, Machiavellianism appears to be the least related to temperamental traits. Thus, it seems that only narcissism and psychopathy confirm the claim about a connection between the Dark Triad traits and a high-approach low-avoidance temperament.
Multiphysical characterization of FSW of aluminum electrical busbars with copper ends
Authors: Ólafsson Dagur , Vilaça Pedro , Vesanko Jussi
Published: November 2019

This work investigates the benefits of having an aluminum (Al) busbar with welded copper (Cu) ends, and evaluates the force relaxation phenomena of a pre-loaded bolt joint on Cu versus Al, under cyclic thermal loading. The results show a force relaxation rate 50% lower in the Cu-bolted joint compared with the one in Al. The core of this research is the weldability analysis of Al-Cu butt joints made by friction stir welding (FSW). The materials are AA1050 H14/24 and Cu OF 04 with thickness of 6 mm. Temperature monitoring during the FSW cycle emphasize how heat generation depends mostly on local internal viscoplastic deformation. Tensile, bending, and microhardness tests were used to establish the mechanical properties. Optical microscope and scanning electron microscopy were used to characterize the microstructure. Joining mechanisms in the weld were investigated using energy-dispersive X-ray spectroscopy. The FSW resulted in 85% tensile strength efficiency compared to the Al base material, and 97% electrical conductivity efficiency compared to an ideal bimetallic component made of the same materials with no contact resistance. Electrical resistance of the FSW is 200 times lower than the electrical contact resistance between the Al-Cu materials while under high compressive force.
Correction to: How the 2018 US Physical Activity Guidelines are a Call to Promote and Better Understand Acute Physical Activity for Cognitive Function Gains
Authors: Chang Yu-Kai , Erickson Kirk I. , Stamatakis Emmanuel , Hung Tsung-Min
Published: November 2019

The article How the 2018 US Physical Activity Guidelines are a Call to Promote and Better Understand Acute Physical Activity for Cognitive Function Gains, written by Yu-Kai Chang, Kirk I. Erickson, Emmanuel Stamatakis and Tsung-Min Hung, was originally published Online First without Open Access. After publication in volume 49, issue 11, pages 1625–1627 [#-#] the author decided to opt for Open Choice and to make the article an Open Access publication.
Simulating the Midlatitude Atmospheric Circulation: What Might We Gain From High-Resolution Modeling of Air-Sea Interactions?
Authors: Czaja A. , Frankignoul C. , Minobe S. , Vannière B.
Published: November 2019

Purpose of Review

To provide a snapshot of the current research on the oceanic forcing of the atmospheric circulation in midlatitudes and a concise update on previous review papers.

Recent Findings

Atmospheric models used for seasonal and longer timescales predictions are starting to resolve motions so far only studied in conjunction with weather forecasts. These phenomena have horizontal scales of ~ 10–100 km which coincide with energetic scales in the ocean circulation. Evidence has been presented that, as a result of this matching of scale, oceanic forcing of the atmosphere was enhanced in models with 10–100 km grid size, especially at upper tropospheric levels. The robustness of these results and their underlying mechanisms are however unclear.

Despite indications that higher resolution atmospheric models respond more strongly to sea surface temperature anomalies, their responses are still generally weaker than those estimated empirically from observations. Coarse atmospheric models (grid size greater than 100 km) will miss important signals arising from future changes in ocean circulation unless new parameterizations are developed.
Commuters’ Willingness to Shift to Metro: a Case Study of Salaya, Thailand
Authors: Fraszczyk Anna , Weerawat Waressara , Kirawanich Phumin
Published: November 2019

The rapid expansion of new metro systems in the last two decades shows a globally growing interest in urban rail transit infrastructure. Every time a new metro line is opened, it has the potential to change the existing modal split, which is usually dominated by private (car or motorcycle) transport users. For each new or expanding metro system, a feasibility study is conducted, which focusses mainly on existing mobility issues, travel demand, new infrastructure proposed, and environmental and financial aspects of a new metro project. In these documents, specific methodologies are applied, using local parameters and suitable software, for demand forecasting purposes. However, not much attention is usually dedicated to potential users, their modal choice characteristics, willingness to shift to metro and conditions under which such a shift would be encouraging. Therefore, it is often unclear what the actual public perception of a new service is and their interest in using it in the future. As a consequence of various shortcomings in feasibility studies, the actual demand for metro services is often much lower than originally predicted. Hence, a survey targeting a group of potential metro users located close to a planned metro line was designed to investigate people’s willingness to shift to metro and include soft factors that could facilitate such a change. Next, a case study of the Red Line whose final metro stop is at Salaya, Thailand, was selected, and a sample of 667 respondents, both staff and students based at a nearby university campus, was investigated. Results revealed that 90% of the sample is willing to shift to metro (easy and medium shifters) for a future 20-km trip between Salaya and Bangkok, while only 10% remains sceptic (difficult shifters). Moreover, there are some differences in shifters’ priorities, where easy shifters see factors such as reliable timetable, good mode connectivity and seamless station–campus connection as significantly more important than medium or difficult shifters do. Also, there is a significant association between a mode type currently used for Salaya and Salaya–Bangkok commutes, where private transport users (51% of staff and 43% of students) have already shifted to public transport. Based on the outcomes of the study, recommendations are addressed to stakeholders involved in the Red Line, as well as in other new metro projects in Thailand and internationally, and to those who aim to better understand the needs of potential customers in order to facilitate their shift to metro as a preferred mode of transport in the future.
A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease
Authors: Lopatko Lindman Karin , Weidung Bodil , Olsson Jan , Josefsson Maria , Kok Eloise , Johansson Anders , Eriksson Sture , Hallmans Göran , Elgh Fredrik , Lövheim Hugo
Published: November 2019

Introduction

Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis.

Methods

Plasma from 360 AD cases, obtained on average 9.6 years before diagnosis, and their age‐ and sex‐matched controls, were analyzed for anti–HSV1 immunoglobulin (Ig) G with enzyme‐linked immunosorbent assays (ELISAs). APOE genotype and nine other selected risk genes for AD were extracted from a genome‐wide association study analysis by deCODE genetics, Reykjavik, Iceland.

Results

The interaction between APOEε4 heterozygosity (APOEε2/ε4 or ε3/ε4) and anti–HSV1 IgG carriage increased the risk of AD (OR 4.55, P = .02). A genetic risk score based on the nine AD risk genes also interacted with anti–HSV1 IgG for the risk of developing AD (OR 2.35, P = .01).

Discussion

The present findings suggest that the APOEε4 allele and other AD genetic risk factors might potentiate the risk of HSV1‐associated AD.
Hustling themtaaway: the Brain Work of the Garbage Business in Nairobi’s Slums
Authors: Chułek Magdalena
Published: November 2019

The inhabitants of slums have developed creative ways of addressing the inherent instability of their lives. Chułek analyzes two approaches to self-organizing work on the basis of data gathered in two slum areas of Nairobi, Kibera and Korogocho, arguing that the key element of slum inhabitants’ actions is the reproduction of structures which enable their survival by making their lives predictable. These structures are evident in the work of trash pickers andorodhapeople, who have developed a finely-tuned infrastructure that governs their actions while allowing room for as many as possible to participate. They can also be seen in the work of hustlers, whose “brain work” is dependent on their network of relationships and on their constant improvisation. These are two examples of the way that inhabitants of Nairobi’s slums manage to maintain a sense of autonomy and agency in the face of constant economic challenge.
A Simple and Accurate 3D Numerical Model for Laser Cladding
Authors: Chien Shih-Kai , Tsai Kuo-Teng , Li Yueh-Heng , Wu Yu-Ting , Chen Wen-Lih
Published: November 2019

A simple numerical model has been proposed for laser cladding. The model does not involve complex techniques such as cell addition, moving mesh, or prescribing a clad profile with a certain polynomial function. Instead, a mass function has been introduced to register the clad mass deposition on substrate, and from which the clad-track height can be estimated. The model takes several operational parameters, laser power, laser-head speed, and clad powder feeding rate, into consideration and predicts clad-track geometry, dilution, and substrate temperature. Experiments using two different combinations of substrate and clad powder materials to lay single and multiple clad tracks were conducted to provide data for model validation. The results show that the present model returns good agreement with experimental clad profiles for single and multiple tracks.
Thermal Stress Analysis of 3D Anisotropic Materials Involving Domain Heat Source by the Boundary Element Method
Authors: Shiah Y. C. , Tuan Nguyen Anh , Hematiyan M.R.
Published: November 2019

In engineering applications, it is pretty often to have domain heat source involved inside. This article proposes an approach using the boundary element method to study thermal stresses in 3D anisotropic solids when internal domain heat source is involved. As has been well noticed, thermal effect will give rise to a volume integral, where its direct evaluation will need domain discretization. This shall definitely destroy the most distinctive notion of the boundary element method that only boundary discretization is required. The present work presents an analytical transformation of the volume integral in the boundary integral equation due to the presence of internal volume heat source. For simplicity, distribution of the heat source is modeled by a quadratic function. When needed, the formulations can be further extended to treat higher-ordered volume heat sources. Indeed, the present work has completely restored the boundary discretization feature of the boundary element method for treating 3D anisotropic thermoelasticity involving volume heat source.
Constraining the geothermal heat flux in Greenland at regions of radar-detected basal water
Authors: Rezvanbehbahani Soroush , Stearns Leigh A. , van der Veen C. J. , Oswald Gordon K. A. , Greve Ralf
Published: November 2019

The spatial distribution of basal water critically impacts the evolution of ice sheets. Current estimates of basal water distribution beneath the Greenland Ice Sheet (GrIS) contain large uncertainties due to poorly constrained boundary conditions, primarily from geothermal heat flux (GHF). The existing GHF models often contradict each other and implementing them in numerical ice-sheet models cannot reproduce the measured temperatures at ice core locations. Here we utilize two datasets of radar-detected basal water in Greenland to constrain the GHF at regions with a thawed bed. Using the three-dimensional ice-sheet model SICOPOLIS, we iteratively adjust the GHF to find the minimum GHF required to reach the bed to the pressure melting point, GHFpmp, at locations of radar-detected basal water. We identify parts of the central-east, south and northwest Greenland with significantly high GHFpmp. Conversely, we find that the majority of low-elevation regions of west Greenland and parts of northeast have very low GHFpmp. We compare the estimated constraints with the available GHF models for Greenland and show that GHF models often do not honor the estimated constraints. Our results highlight the need for community effort to reconcile the discrepancies between radar data, GHF models, and ice core information.
FACTORIALS OF INFINITE CARDINALS IN ZF PART I: ZF RESULTS
Authors: SHEN GUOZHEN , YUAN JIACHEN
Published: November 2019

For a set x, let ${\cal S}\left( x \right)$ be the set of all permutations of x. We prove in ZF (without the axiom of choice) several results concerning this notion, among which are the following:

(1) For all sets x such that ${\cal S}\left( x \right)$ is Dedekind infinite, $\left| {{{\cal S}_{{\rm{fin}}}}\left( x \right)} \right| < \left| {{\cal S}\left( x \right)} \right|$ and there are no finite-to-one functions from ${\cal S}\left( x \right)$ into ${{\cal S}_{{\rm{fin}}}}\left( x \right)$, where ${{\cal S}_{{\rm{fin}}}}\left( x \right)$ denotes the set of all permutations of x which move only finitely many elements.

(2) For all sets x such that ${\cal S}\left( x \right)$ is Dedekind infinite, $\left| {{\rm{seq}}\left( x \right)} \right| < \left| {{\cal S}\left( x \right)} \right|$ and there are no finite-to-one functions from ${\cal S}\left( x \right)$ into seq (x), where seq (x) denotes the set of all finite sequences of elements of x.

(3) For all infinite sets x such that there exists a permutation of x without fixed points, there are no finite-to-one functions from ${\cal S}\left( x \right)$ into x.

(4) For all sets x, $|{[x]^2}| < \left| {{\cal S}\left( x \right)} \right|$.
Friendship networks and adolescent pregnancy: Examining the potential stigmatization of pregnant teens
Authors: Humberstone Elizabeth
Published: November 2019

Though declining since the 1990s, adolescent pregnancy remains common in the United States. Social supports appear to improve outcomes for pregnant teens; however, teen pregnancy introduces social obstacles, such as stigma. This study investigates how currently or previously pregnant teens’ friendship networks differ from nonpregnant girls using data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) and multilevel regression models. To mitigate concerns that background differences contribute to both pregnancy risk and social networks, girls who experience a pregnancy prior to one data collection time point are compared girls who experience their first pregnancy after this time point. This group who become pregnant after the time point is presumably more similar to already pregnant teens than those never experiencing teen pregnancy. When compared to these girls who become pregnant in the future, those who have already experienced a teen pregnancy report similar numbers of friends (out-nominations) and perceived social acceptance, but are predicted to have fewer peers reporting them as friends (in-nominations) and fewer reciprocated friendships. This suggests that pregnant teens may face stigmatization, of which they may be unaware. It further highlights a new comparison group to account for selection in studies of adolescent pregnancy.
The networked question in the digital era: How do networked, bounded, and limited individuals connect at different stages in the life course?
Authors: Wellman Barry , Quan-Haase Anabel , Harper Molly-Gloria
Published: November 2019

We used in-depth interviews with 101 participants in the East York section of Toronto, Canada to understand how digital media affects social connectivity in general—and networked individualism in particular—for people at different stages of the life course. Although people of all ages intertwined their use of digital media with their face-to-face interactions, younger adults used more types of digital media and have more diversified personal networks. People in different age-groups conserved media, tending to stick with the digital media they learned to use in earlier life stages. Approximately one-third of the participants were Networked Individuals: In each age-group, they were the most actively using digital media to maintain ties and to develop new ones. Another one-third were Socially Bounded, who often actively used digital media but kept their connectivity within a smaller set of social groups. The remaining one-third, who were Socially Limited, were the least likely to use digital media. Younger adults were the most likely to be Networked Individuals, leading us to wonder if the percentage of the population who are Bounded or Limited will decline over time.
Supernova lightCURVE POPulation Synthesis II: Validation against supernovae with an observed progenitor
Authors: Eldridge J. J. , Guo N. -Y. , Rodrigues N. , Stanway E. R. , Xiao L.
Published: November 2019

We use the results of a supernova light-curve population synthesis to predict the range of possible supernova light curves arising from a population of single-star progenitors that lead to type IIP supernovae. We calculate multiple models varying the initial mass, explosion energy, nickel mass and nickel mixing and then compare these to type IIP supernovae with detailed light curve data and pre-explosion imaging progenitor constraints. Where a good fit is obtained to observations, we are able to achieve initial progenitor and nickel mass estimates from the supernova lightcurve that are comparable in precision to those obtained from progenitor imaging. For 2 of the 11 IIP supernovae considered our fits are poor, indicating that more progenitor models should be included in our synthesis or that our assumptions, regarding factors such as stellar mass loss rates or the rapid final stages of stellar evolution, may need to be revisited in certain cases. Using the results of our analysis we are able to show that most of the type IIP supernovae have an explosion energy of the order of log(Eexp/ergs) = 50.52 ± 0.10 and that both the amount of nickel in the supernovae and the amount of mixing may have a dependence on initial progenitor mass.
A digital correlation receiver for the Mingantu Spectral Radioheliograph
Authors: Liu Fei , Yan Yihua , Wang Wei , Tan Baolin , Chen Linjie , Qu Chunhui , Li Jutao
Published: November 2019

We have designed and developed the digital correlation receiver for Mingantu Spectral Radioheliograph (MUSER). The MUSER digital correlation receiver is implemented to sample, channelise, and correlate a 400 MHz wide solar radio signal of 40-antenna output from MUSER intermediate-frequency array and 60-antenna output from MUSER high-frequency array. The polyphase filter channeliser is used for wide-band channelisation and proved to be efficient to realise narrow-band filtering (

${\sim}25$

MHz) in a high-speed digital signal-processing pipeline (sampling rate

${\sim}1$

Gsps). All modules of the digital correlation receiver are implemented on FPGA-based hardware and integrated via high-speed backplane, which makes a well-performed and economical correlator system for MUSER array. The future upgrade is also addressed including spectral resolution enhancement and radio-frequency-interference excision.
Greenhouse gas emissions in a subtropical jasmine plantation managed with straw combined with industrial and agricultural wastes
Authors: Jin Qiang , Liu Haitao , Wang Chun , Wang Xiaotong , Min Qingwen , Wang Weiqi , Sardans Jordi , Liu Xiaohui , Song Xu , Huang Xiaoting , Peñuelas Josep
Published: November 2019

The effects of straw alone or combined with industrial and agricultural wastes as fertilizers on greenhouse gas (GHG) emissions are still poorly known in cropland areas. Here, we studied the effects of 3.5 Mg ha−1 straw and 3.5 Mg ha−1 straw combined with 8 Mg ha−1 of diverse wastes on GHG emission in a subtropical Jasminum sambac plantation in southeastern China. There were five treatments in a completely randomized block design: control, straw only, straw + biochar, straw + steel slag, and straw + gypsum slag. Emissions of carbon dioxide were generally higher in the treatments with waste than in the control or straw-only treatments, whereas the contrary pattern was observed in CH4 and N2O emission rates. Moreover, the total global warming potentials (GWPs) were no significantly higher in most of the amended treatments as compared to the control and straw-only treatments. In relation to the treatment with only straw, GWPs were 9.4% lower when steel slag was used. This finding could be a consequence of Fe amount added by steel slag, which would limit and inhibit the emissions of GHGs and their transport from soil to atmosphere. Our results showed that the application of slags did not increase the emission of GHGs and that the combination of straw with steel slag or biochar could be more effective than straw alone for controlling GHGs emission and improve soil C and nutrient provision.
How epidemiological patterns shift across populations in an exotic lizard
Authors: Bezerra C.H. , Pinheiro L.T. , Melo G.C. , Braga R.R. , Anjos L.A. , Borges-Nojosa D.M.
Published: November 2019

Several factors influence the dynamics and structure of parasite communities. Our goal was to investigate how the community composition, prevalence and abundance of parasites change across seven populations of the exotic lizard Hemidactylus mabouia in Northeast Brazil, and to describe ontogenetic and sex variations. We found differences in the composition of component communities and patterns of infection according to the host body size across the lizard populations. We did not find any variation between the sexes regarding epidemiological patterns, which can probably be explained by the similar diet and habitat use of male and female H. mabouia. An unusually high abundance and prevalence of trematodes infecting this host lizard was apparent when we compared other native lizard hosts, and we suggest that local environmental conditions might be advantageous to the development and life cycle of these parasites due to the abundance of all the intermediate and definitive hosts.
Beyond programmatic versus patrimonial politics: contested conceptions of legitimate distribution in Nigeria
Authors: Roelofs Portia
Published: November 2019

This article argues against the long-standing instinct to read African politics in terms of programmatic versus patrimonial politics. Unlike the assumptions of much of the current quantitative literature, there are substantive political struggles that go beyond ‘public goods good, private goods bad’. Scholarly framings serve to obscure the essentially contested nature of what counts as legitimate distribution. This article uses the recent political history of the Lagos Model in south-west Nigeria to show that the idea of patrimonial versus programmatic politics does not stand outside of politics but is in itself a politically constructed distinction. In adopting it a priori as scholars we commit ourselves to seeing the world through the eyes of a specific, often elite, constituency that makes up only part of the rich landscape of normative political contestation in Nigeria. Finally, the example of a large-scale empowerment scheme in Oyo State shows the complexity of politicians’ attempts to render distribution legitimate to different audiences at once.