bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrospect?ve compar?son of cl?n?cal and rad?olog?cal results of conservat?ve and lock?ng anatom?cal plates for neer type 2 and type 3 prox?mal humerus fractures ?n pat?ents over 40 years of age
Authors: Artıran Ferit Birand
Published: July 2024

Proximal humerus fractures are one of the most common fractures in adults. Its incidence is increasing day by day with the increase in life expectancy in society. It was aimed to compare the radiological and functional results of patients over the age of 40 who were treated with conservative and anatomical locking plate (Philos) in our clinic due to Neer type 2 and type 3 proximal fractures.

82 patients who came to Bursa Uludağ University Hospital Orthopedics and Traumatology Clinic and Polyclinic with the diagnosis of Neer type 2 and type 3 proximal humerus fractures between January 2010 and December 2020, whose treatment was planned and completed, and who came for periodic control after discharge, were included in the study. For this purpose, X-ray radiographs, surgery notes and electronic file records in the PACS system were used. The functional results of the patients were evaluated according to the physical examinations at their last follow-up and Constant, ASES and DASH shoulder scoring.

There was no significant difference in functional and radiological results between patients treated with conservative treatment and plate. In the measurements made at the last follow-up, the average head-neck angle was 136.2 (115-165) in the conservative group and 134.4 (113-165) in the surgical group. According to the Constant-Murley scoring in the evaluation made at the last follow-up of the patients, the median value out of a total of 100 points was 65.9 (10-98) in the conservative group and 73.9 (35-98) in the surgical group. ASES score is calculated out of a total of 100 points. The median value was 63.3(5-100) in the conservative group and 68.3(23.3-95) in the surgical group. DASH score is calculated from 0 at best to 100 at worst. The median value was 33.3(0-97.5) in the conservative group and 25(4.2-71.7) in the surgical group.

In proximal humerus fractures, the fracture type and morphology should first be well defined and classified. When planning the treatment of patients, decisions should not only be made based on the type of fracture, but the treatment plan should also be taken into account by taking into account the patient's functional expectations and comorbidities.
Case report of unusual foreign body in the rectum
Authors: Ahmad Zubair , Audichya Abhay , Shah Nimish J
Published: July 2024

Encountering a foreign object in the rectum is rare; however, the incidence has greatly increased in recent years. Treatment of these patients requires a multidisciplinary approach because this condition may have serious complications. The review of diagnosis and treatment process in a case of intrarectal foreign object is presented.
Case series- study of pancreatic lesions and it’s management in a rural tertiary healthcare centre
Authors: Pakkal Shreya , Kale Amogh , Apturkar Dilip , Taparia Mridul
Published: July 2024

Pancreatic cancer (PC) is a rising public health threat and is anticipated to account for over 48,000 cancer-related deaths by 2030. Significant advances in surgical technique have resulted in decreased perioperative morbidity and mortality after pancreatic resection. Management includes a multi modality program with neoadjuvant therapy and surgical resection.

Inflammatory tumors, cystic and neuroendocrine neoplasms, and periampullary adenomas are other growing entities of pancreatic diseases. Patients present with symptoms of epigastric tenderness, jaundice, nausea, vomiting.

Many surgical procedures have been proposed for periampullary tumors; these range from palliative bypass of the biliary and gastrointestinal tracts, local excisions, total pancreatectomy, and traditional pancreatoduodenectomy or the Whipple procedure. Each of these various procedures has been designed to answer a problem with postoperative mortality, long-term gastrointestinal function, or long-term survival.

: To study clinical features and management of pancreatic lesions over a course of 1 year in a rural tertiary health care set up.
A case of bilateral straatsma syndrome
Authors: Gupta Kanav , Chawla Bhawna , Garg Kritika , Gupta B.K
Published: July 2024

Straatsma syndrome is characterized by a constellation of conditions including amblyopia, nystagmus, and myopia. We present the case of a 10-year-old boy who complained of involuntary back-and-forth eye movements and reduced vision since birth. His visual acuity was measured at 2/60 in both eyes. Examination revealed horizontal pendular nystagmus without ocular misalignment. Fundus examination showed myopic changes, including an anomalous optic disc with extensive myelinated nerve fibers extending from the optic disc along the superior and inferior arcades to the fovea. Axial length measurements were 28.34 mm and 27.96 mm in the right and left eyes, respectively. SD-OCT imaging confirmed thickening of the retinal nerve fiber layer. Treatment included cycloplegic refraction and occlusion therapy, with regular follow-ups every three months utilizing contact lenses with cycloplegic refraction. The etiology of retinal fiber myelination remains unclear; however, it is hypothesized that blurred retinal imaging during critical ocular development stages may lead to axial elongation and subsequent myopia, potentially delaying the development of the lamina cribrosa and facilitating myelination extension.
Gestão da Plataforma EaD CBMES e o Panorama da Educação a Distância nos Corpos de Bombeiros
Authors: Marçal Dias Dainer , Porto Bruno , Battestin Vanessa
Published: July 2024

Os Corpos de Bombeiros Militares possuem uma cartela de atribuições variadas. O desafio nesse contexto é conseguir difundir ensino de forma significativa, uniforme e com alcance. Ferramentas de educação a distância em ambientes virtuais de aprendizagem surgem atualmente como uma alternativa para compartilhar ensinamentos, tanto em empresas privadas como nas públicas, apresentando-se como uma possibilidade a ser explorada pelos corpos de bombeiros. O objetivo dessa pesquisa foi explorar a gestão da Plataforma EaD CBMES, avaliar o que já está sendo realizado e indicar pontos a melhorar. Para tanto, foi realizada uma pesquisa com os Corpos de Bombeiros Militares do país, fazendo um levantamento do que está sendo produzido nas outras corporações, visando verificar o posicionamento do CBMES no contexto nacional e conseguir captar boas práticas a serem desenvolvidas. Paralelamente, foi levantado o que já está gerando resultado na plataforma e o que falta ser implementado, tanto a nível de conteúdo, quanto a nível formal de publicação de portarias, manuais e padronizações. Ao final desse trabalho verificou-se que a Plataforma EaD CBMES é uma fonte viável e consistente para disseminar conhecimento, tanto para o público interno quanto para o externo, propiciando fortalecimento no ensino da corporação, visando sempre o lema de vida alheia e riquezas salvar, valorizando assim os bens mais valiosos para o CBMES, o seu bombeiro e a população capixaba. 
 
Palavras-chave: Educação a distância. MOOC. Bombeiros.
Tecnologias Utilizadas por Regentes na Educação Infantil no Contexto Pandêmico – Aspectos Éticos e Instrumentais
Authors: Pinheiro Istesio Junior , Valim Rosa Lidice de Moraes , Moraes Regina Celia Pereira de
Published: July 2024

O ambiente da Educação Infantil tem o propósito de auxiliar no processo de desenvolvimento da criança. Nesse ambiente, ela precisa poder manifestar-se através de diferentes linguagens, bem como sentir-se cuidada. No entanto, a partir do ano de 2020, o ambiente lúdico e pedagógico transmutou-se, devido à pandemia de COVID-19. Diversos sistemas educacionais por todo o mundo precisaram traçar estratégias compatíveis com as possibilidades de que dispunham, de forma a garantir o direito básico à educação. Remetendo a tal contexto, este artigo objetiva elaborar reflexões sobre as tecnologias digitais utilizadas pelos regentes da Educação Infantil do município de Maricá (RJ), junto às crianças na faixa etária de 04 a 05 anos, para aulas remotas durante o período de isolamento imposto pela pandemia. Para tanto, apresentam-se reflexões bibliográficas e, em seguida, preliminares de pesquisa, de acordo com as orientações da Resolução nº 510, de 2016, do Conselho Nacional de Saúde. Os achados sugerem que, no mencionado contexto, ferramentas tecnológicas digitais de baixo custo e fácil aplicabilidade – como o WhatsApp – tendem a promover os melhores resultados.
 
Palavras-chave: Educação infantil.Tecnologias para educação. Educação no contexto pandêmico. Considerações ético-pedagógicas para Educação Infantil.
Ensino-aprendizagem de Língua Espanhola na Modalidade a Distância: um Mapeamento Sistemático de Literatura
Authors: Coelho Iandra Maria Weirich da Silva , Teixeira Wagner Barros
Published: July 2024

Neste artigo, apresentamos um panorama atual de pesquisa sobre o processo de ensino-aprendizagem de Língua Espanhola, na modalidade de Educação a Distância, em contexto educacional brasileiro. Para tanto, realizamos um estudo exploratório, por meio de mapeamento sistemático de literatura, compreendendo a análise de um corpus composto por vinte e cinco estudos, publicados no período de 2013 a 2022. Os resultados obtidos com maior frequência demostram:  uso da Abordagem Comunicativa, tendência para uso de Metodologias Ativas como a Gamificação e a Aprendizagem Baseada em Projetos, predominância da Teoria de Gêneros, da Teoria Sociointeracionista e da perspectiva do Letramento Digital como referenciais mais utilizados, preferência pelo uso do fórum e do Chat como principais ferramentas, do Moodle como plataforma, e aumento significativo no quantitativo de estudos voltados para criação e avaliação de cursos de LE, em EaD, seguidos pelo desenvolvimento da habilidade de produção oral, como problemáticas mais estudadas.
 
Palavras-chave: Educação a distância. Ensino-aprendizagem. Língua espanhola.  Mapeamento  sistemático.
Ensino Híbrido: um Estudo de Caso Acerca das Experiências Vivenciadas por Professores e Estudantes de Cursos de Nível Superior de uma Instituição Pública da Rede Federal
Authors: Silva Fabíola Freire da , Larré Julia Maria Raposo Gonçalves de Melo
Published: July 2024

É irrefutável que a pandemia provocada pela Covid-19 trouxe impactos importantes sobre toda a sociedade. Concernentemente ao campo educacional, as Tecnologias Digitais de Informação e Comunicação (TDIC) foram incorporadas subitamente por meio do ensino remoto emergencial, que, a posteriori, abriu espaço, pontualmente, para experiências híbridas. O ensino híbrido ou blended learning é apontado como uma tendência educacional para este século, tendo em vista que não se limita a um único modo, tempo e espaço. Além disso, as TDIC podem ser grandes aliadas do processo de ensino-aprendizagem (Staker; Horn, 2015); (Bacich; Moran, 2018). Dado isso, considerando o recorte temporal da crise sanitária, especificamente os semestres 2021.2 e 2022.1, o objetivo geral deste artigo foi analisar as potencialidades e limitações relacionadas à aplicação do ensino híbrido em cursos de nível superior de uma instituição pública da rede federal. Para isso, foram traçados dois objetivos específicos: (i) caracterizar as práticas pedagógicas implementadas, por meio do ensino híbrido, considerando estritamente os semestres letivos supramencionados; (ii) identificar as potencialidades e limitações relativas ao ensino híbrido, nas percepções dos docentes e discentes da instituição investigada. Relativamente à metodologia aplicada, possui abordagem mista, sendo na fase inicial qualitativa e, posteriormente, quantitativa. Ademais é uma pesquisa de natureza aplicada, caracterizada como estudo de caso. Ressalta-se que este trabalho é oriundo de uma pesquisa de mestrado, na qual foi possível mapear as potencialidades e limitações vivenciadas pelos discentes e docentes com a implementação do blended learning, refletir sobre elas e discuti-las a partir das fundamentações científicas publicadas e, sobretudo, trazer resultados que possibilitem gerar mudanças e aperfeiçoamentos ao processo educacional.
 
Palavras-chave: Educação a distância. Ensino superior. Tecnologias digitais. Ensino híbrido.
Precisão e Confiabilidade do ChatGPT na Percepção de Estudantes da Graduação EaD
Authors: Loiola Alba , Sachete Andreia Santos , Grandi Roges Horacio , Gomes Raquel Salcedo
Published: July 2024

Este estudo teve como objetivo identificar a percepção de estudantes de graduação sobre o uso da ferramenta ChatGPT, considerando a exatidão das respostas, a confiabilidade, seu potencial de aprendizagem e aplicações profissionais. Para isso, foi proposta uma atividade para estudantes de graduação que cursaram a disciplina Métodos e Técnicas de Estudo na modalidade à distância, vinculados a uma instituição de ensino superior particular situada na Baixada Fluminense, na cidade do Rio de Janeiro. A oferta da disciplina é feita em todos os cursos de graduação ao longo do terceiro período. A atividade desenvolvida consistia em utilizar a ferramenta para responder a conceitos teóricos em sua área de atuação e, em seguida, responder a um questionário com perguntas discursivas sobre a ferramenta. Obteve-se um total de 47 respostas, que foram investigadas à luz da análise qualitativa do conteúdo. Como resultado, observou-se que os respondentes percebem a utilidade da ferramenta, mas identificam questões de natureza ética relacionadas ao seu uso, assim como possíveis desafios no que tange ao desenvolvimento da aprendizagem.
 
Palavras-chave: ChatGPT. Ferramenta educacional. Processo de ensino-aprendizagem. Educação superior.
Instrumento para Avaliação de User Experience em Serviços de Educação Superior a Distância
Authors: Bertagnolli Bruno , Mager Gabriela Botelho
Published: July 2024

Considerando a expansão de serviços de Educação Superior a Distância (ESaD) e a necessidade de sua avaliação por meio de instrumentos validados, esta pesquisa propõe um instrumento voltado para mensurar a Experiência do Usuário (Ux) em tal contexto. A pesquisa caracteriza-se como aplicada, qualiquantitativa, exploratória e descritiva, composta de (I) Etapa teórica (mapeamento de dimensões e fatores de Ux); (II) Definição do instrumento piloto (mapeamento de personas e experiência, definição do construto e do modelo piloto, validação do conteúdo com especialistas (n=8) e usuários (n=12) e (III) Validação (aplicação do instrumento / n=181), análise de fatores e consistência interna). Como resultado, foi proposta a EASE-Ux (Escala de Avaliação de Serviços de Educação a Distância pela Experiência do Usuário), constituída de 31 itens organizados nas dimensões de “Elementos Centrais” (itens relacionados à Estrutura tecnológica do polo, Tutoria, Disciplinas e conteúdo, Material didático e Imagem final) e “Elementos de apoio” (itens relacionados à Comunicação, Processos, Tecnologia, Suporte, Estrutura física do polo e Imagem prévia). As análises de validade e confiabilidade indicaram que o instrumento mensura de forma concisa o construto, podendo fornecer dados voltados para a melhoria do serviço. O estudo também contribui para a literatura de Ux e de serviços, abrindo possibilidades para novas pesquisas relacionadas aos temas.
 
Palavras-chave: Design de serviços. Educação superior a distância. Experiência do usuário.
Identificação dos Aspectos Sociais e Afetivos da Competência Socioafetiva Resiliência de Discentes no Ensino Superior em Ambiente Virtual de Aprendizagem
Authors: Vivian Rafael Leonardo , Machado Leticia Sophia Rocha , Behar Patricia Alejandra
Published: July 2024

O objetivo deste artigo é identificar os aspectos sociais e afetivos da Competência Socioafetiva Resiliência de discentes do ensino superior em ambiente virtual de aprendizagem. À medida que os estudantes enfrentam adversidades acadêmicas, a adaptação a novos ambientes e as demandas emocionais e sociais, torna-se evidente a necessidade de construir competências socioafetivas. Contudo, é fundamental investigar quais são os aspectos sociais e afetivos que podem impactar na construção da resiliência do estudante. Para alcançar tal propósito, foi realizada uma avaliação com especialistas em competências socioafetivas e educação a distância, abrangendo 119 itens de sete escalas e questionários de resiliência, juntamente com o conjunto dos elementos de conhecimentos, habilidades e atitudes dessa competência. Desse modo, os resultados revelaram a importância dos aspectos afetivos e sociais: confiança, esforço, animado, entusiasmo, interesse, serenidade, realização, esperança, satisfeito, orgulho, abertura, independência e colaboração. Logo, esses resultados fornecem uma visão abrangente dos aspectos que podem influenciar a construção da Competência Socioafetiva Resiliência, enfatizando a interconexão desses indicadores e sua importância para os estudantes enfrentarem as adversidades oriundas das relações estabelecidas em ambiente virtual de aprendizagem, especialmente na educação a distância.  
 
Palavras-chave: Ensino superior. Ambiente virtual de aprendizagem. Competências socioafetivas. Resiliência.
Tutoria no Contexto da EaD: Ação Mediada em uma Perspectiva Sociocultural
Authors: Fazio Anahy Arrieche , Heckler Valmir , Galiazzi Maria do Carmo
Published: July 2024

O estudo comunica compreensões emergentes sobre os significados relacionados ao papel da mediação do tutor na modalidade da educação a distância, ancorando-se em uma fundamentação teórica na perspectiva sociocultural. Trata-se de um ensaio teórico de cunho fenomenológico-hermenêutico, comunicado em uma breve revisão narrativa. As compreensões emergem da análise constituída no levantamento de dados e coleta de informações disponíveis sobre o tutor na legislação da EaD no Brasil, coconstruídas com estudos da comunidade científica brasileira e articuladas à significação teórica da mediação na perspectiva sociocultural. Como resultados, destaca-se que a mediação do tutor na modalidade da educação a distância pode ser compreendida como uma ação mediada por meios mediacionais. Nisso, os meios mediacionais para a ação do tutor envolvem artefatos/ferramentas, como a escrita, a pergunta e a fala (áudio), além dos diversos modos de representação semiótica dos temas em estudo nas atividades em desenvolvimento. 
 
Palavras-chave: Educação a distância. Tutor. Mediação. Ação mediada. UAB.
Uso de Tecnologias da Informação e Comunicação entre Trabalhadores da Saúde
Authors: Maia Camila do Couto , Locks Melissa Orlandi Honório , Ferraz Fabiane , Stein Mônica , Salum Nádia Maria Chiodelli , Trombetta Ana Paula
Published: July 2024

Na área da saúde a inserção das tecnologias e inovações tecnológicas cresce de maneira exponencial, apresentando alto poder de transformação, exigindo uma acelerada apropriação de competências e habilidades pelos profissionais. Nesse contexto, apesar das importantes potencialidades, ainda são encontradas diversas barreiras na aproximação entre as pessoas e as tecnologias, seja pela falta de conhecimento, dificuldade de utilização, desafios na implementação, necessidade de suporte dos profissionais de informática, dentre outros fatores. Nesse sentido, este estudo objetivou conhecer o perfil e identificar a percepção dos trabalhadores estaduais da saúde de Santa Catarina em relação ao uso de tecnologias da informação e comunicação. Trata-se de um estudo do tipo descritivo, com abordagem quantitativa. Foi aplicado um questionário eletrônico com trabalhadores da Secretaria de Estado da Saúde de Santa Catarina, de junho a setembro de 2022, obtendo n=107 respostas válidas, analisadas de forma descritiva e por análise de conteúdo. A maioria dos participantes são do sexo feminino (n=80; 74,77%), idade média de 43,81 anos e remetem tecnologia à facilidade, agilidade, praticidade, informação e inovação. A maioria (n=72; 67,29%) afirmou já ter passado por dificuldades no uso de tecnologias, relacionadas a problemas de acesso, usabilidade, conectividade, falta de conhecimento e infraestrutura. As tecnologias mais utilizadas no processo de trabalho são e-mail, computador, WhatsApp, internet e Sistema de Gestão de Processos Eletrônicos. Os resultados apontaram que é preciso atuar na resolução de problemas, melhora de equipamentos, além de oferecer meios de instrução sobre tecnologias.
 
Palavras-chave: Tecnologia. Saúde. Tecnologia da informação e comunicação. Tecnologias em saúde.
Fiqh Aqalliyah as a Legal alternative to Halal Standardization in Japan as a non-Majority Muslim Country
Authors: Rasam Zulifan , Zuhdi Muhammad Luthfi , Shobichatul Aminah
Published: July 2024

The increasing number of Muslim populations in the world has led to the development of the halal industry in both Muslim-majority countries and Muslim-minority countries. Japan is one of the non- Muslim majority countries that is actively developing the halal industry to meet the needs of Muslims both domestically and for export purposes. This research discusses the problems faced by Japan in meeting the needs of halal products for Muslims in Japan. Japan is experiencing problems related to halal standardization because the halal standards applied in Japan are halal standards from several Muslim-majority countries such as Indonesia, Malaysia and the United Arab Emirates. This study uses qualitative research methods through observation, in-depth interviews and FGD to explore the problems encountered in determining halal standards in Japan. This study found that the implementation of halal standards of Muslim majority countries to Muslim minority countries raises complex problems. For this reason, fiqh aqalliyah, which takes into consideration the geographical, social and cultural conditions of the community, can be a legal alternative for determining product halalness or halal standard in Muslim minority countries.
Keywords: Halal Standardisation, Japan, Muslim Minority Country, fiqh aqalliyat
Preventing Intolerant Understandings, Attitudes, and Behaviors Among Generation Z Muslims in Public and Islamic Schools
Authors: Purba Mariati , Hadiana Deni , Darraz Muhammad Abdullah , Ariantoni  , Hendrawati Sri , Helmy Muhammad Irfan
Published: July 2024

This research aims to explore school efforts to enhance resilience against intolerance through school policies. The study builds upon a survey conducted by previous researchers, which revealed that intolerant thoughts, attitudes, and behaviors have influenced Generation Z Muslim students in high schools. This research employs a qualitative method by conducting an in-depth and comprehensive analysis of the phenomena and the meaning of events, social dynamics, attitudes, beliefs, and perceptions of individuals or groups closely related to intolerance in high schools. The phenomena are examined through interviews, observations, and focus group discussions (FGD). The research findings conclude that schools have implemented various measures to enhance the resilience of the school community members through both internal and external policies. These include school policies and vision, curriculum quality and teaching, leadership and management, culture, student activities, and collaboration with external parties, including the facilitation of extracurricular activities. The research provides recommendations for more comprehensive efforts by developing a model of school policy insertion, both internal and external, that emphasizes tolerance values and prevents violence in schools.
 
Keywords: Intolerance, Violence, School Prevention, Z-generation
Written vs generated text: “naturalness” as a textual and psycholinguistic category
Authors: Kolmogorova Anastasia V. ,   The National Research University Higher School of Economics (HSE University), Margolina Anastasia V. ,   Actum CBP d.o.o. Beograd
Published: July 2024

In the context of the development of text generation technologies, the opposition “naturalness − unnaturalness of text” has been transformed into a new dichotomy: “naturalness – artificiality”. The aim of this article is to investigate the phenomenon of naturalness in this context from two perspectives: analyzing the linguistic characteristics of a natural text against a generated (artificial) text and systematizing introspective perceptions of Russian native speaker informants as to what a “natural” text should be like and how it should differ from a generated text. The material for the study was a parallel corpus of film reviews in Russian, consisting of two subcorpora: reviews written by people and those generated by a large language model based on prompts, which are the beginnings of reviews, from the first subcorpus. The following methods were applied for the comparative analysis of the two subcorpora: computer-assisted text processing for calculating the values of 130 metrics of text linguistic complexity, psycholinguistic experiment, expert text analysis, contrastive analysis. As a result, it was determined that from the point of view of their own linguistic characteristics, “natural” texts differ from generated texts mainly by greater flexibility of syntactic structure, allowing both omission or reduction of structures and redundancy, as well as by slightly greater lexical variability. Naturalness as a psycholinguistic category is related to the informants’ autostereotypical ideas about the cognitive characteristics of people as a species. The analysis of texts erroneously attributed by informants (generated, labelled as natural and vice versa) showed that a number of characteristics of this autostereotype are overestimated by informants, while others, in general, correlate with the linguistic specificity of texts from the subcorpus of written reviews. In conclusion, we formulate definitions of naturalness as a textual and psycholinguistic category.
The Significance of Evolutionary Concepts in Biology for the Formation of Evolutionary and Ecological Thinking
Authors: Ilyin Alexander A. ,   Institute of Philosophy of the Russian Academy of Sciences
Published: July 2024

This article is devoted to the philosophical analysis of the theoretical and methodological foundations of evolutionary and ecological thinking. The conceptual development of such thinking is a crucial direction in the advancement of modern life sciences. However, within the foundations of evolutionary and ecological interpretation across various biological fields, contradictions between evolutionary and ecological approaches are explicitly evident. This situation arises because the ecological approach views humans as an active factor in the evolution of their environment while simultaneously assuming their natural immutability, i.e., considering them the pinnacle of evolution. The author attempts to identify the principles for selecting evolutionary theories and concepts that underpin the formation of evolutionary and ecological thinking. In this context, the author addresses various branches of evolutionism, such as classical Darwinism, the synthetic theory of evolution, nomogenesis, autogenesis, orthogenesis, catastrophism, neo-Lamarckism, Autopoietic Theory, mutual aid, and symbiosis in evolution. The conclusion is drawn that effective evolutionary and ecological thinking cannot rely solely on the biological characteristics of evolutionism but requires a philosophical understanding of the cultural and historical status of humans in the world.
HSPD1 gene polymorphism is associated with an increased risk of ischemic stroke in smokers
Authors: Stetskaya Tatiana A. ,   Kursk State Medical University, Kobzeva Ksenia A. , Zaytsev Sergey M. , Shilenok Irina V. , Komkova Galina V. , Goryainova Natalia V. , Bushueva Olga Yu. ,   Kursk State Medical University,   Pavlov First Saint Petersburg State Medical University,   Kursk City Clinical Emergency Hospital,   Kursk State Medical University,   Kursk State Medical University,   Kursk State Medical University
Published: July 2024

Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. Since the influence of vascular stressors prompts cross-reactivity with microbial and human HSPD1 (HSP60), which results in the degradation of vascular endothelium and intimal infiltration by mononuclear cells, HSP60 is viewed as a key player in the autoimmune theory of atherosclerosis. The aim of the study: The present pilot study investigated whether the tag SNP rs11682567 HSPD1 is associated with the risk of IS. Materials and methods: DNA samples from 1176 unrelated Russian subjects (708 IS patients and 468 healthy controls) were genotyped for tagging SNP rs11682567 in the HSPD1 gene using the MassArray-4 system. A log-additive regression model was used to interpret the associations between genotypes and IS risk. Results: We discovered that smoking, a major environmental endothelial stressor, dramatically modifies the link between rs11682567 and IS, with a relationship only being seen in smokers (risk allele G; OR = 2.11, 95% CI = 1.17-3.82; P = 0.0075). The functional annotation of this SNP revealed that risk allele G of rs11682567 impacts the expression and alternative splicing of genes that regulate brain ischemia-reperfusion injury, reactive oxygen species production, toll-like receptor 4 internalization, and pro-inflammatory properties. Moreover, allele G rs11682567 creates binding sites for transcription factors jointly involved in biological processes encompass neurogenesis, monocyte differentiation, fatty acid metabolism, cell signalling, and apoptosis. Conclusion: Thus, rs11682567 SNP in the HSPD1 gene represents a novel genetic marker of ischemic stroke, whose significance for the pathogenesis of IS is mediated by smoking.
FMID based model validation approaches for Rheumatoid arthritis and associated cardiovascular complications: an attempt towards translational competence
Authors: Dubey Trupti , Patel Kirti V.
Published: July 2024

Introduction: The present in-vivo experiment was designed to validate newly developed rat models for Rheumatoid Arthritis (RA) as well as cardiovascular complications in RA for translational competence of disease with clinical situation. The FIMD (Framework to Identify Models for Disease) method based on etiology, pathophysiology, symptomatology, and response to therapeutic interventions was used to compare these models sensitized with primary (CFA, bovine collagen type II) and secondary inducing agents (high fat diet, lipopolysaccharide) in different combinations.
Materials and Methods: Twenty-four Wistar male rats (four groups/n=6) were taken after prevalidation, where a large dataset was analyzed by using statistical methods (one way ANOVA, repeated Measure ANOVA). Among these groups, two best models from RA representative groups and two best models from cardiovascular complications in RA generated groups were taken for final comparison and validation by the same weight score method for obtaining a percentage similarity and validity score using a radar plot based on FIMD to get the best suited model.
Results and Discussion: The findings of this study on the basis of FIMD showed that the collagen (0.1 mL)+lipopolysaccharide (10 µg/mL) induced model is closely fit for preclinical events of RA, with the highest validity score (82%) among all groups and the collagen (0.1 mL)+ lipopolysaccharide (10 µg/mL)+HFD represents a validated model (95%) for co-morbid cardiovascular complications in RA.
Conclusion: The developed and validated models were a fresh attempt using different inducers sequentially to culminate the emerging issue of extra organ manifestation in existing RA via a similar pathway, which can be a contributor to future research in drug discoveries in pharmacology.
Changing aesthetic ideals under the influence of the phenomenon of the cult of youth in the 1920s
Authors: Muzalevskaya Julia E. ,   St. Petersburg State University of Industrial Technologies and Design
Published: July 2024

Introduction. The principle of aesthetic transformation affects not only the functioning of fashion, but also a range of problems related to the worldview and world perception of a person, which are relevant for any time. Aesthetic problems have a deeper foundation than the change of images of vestimentary fashion, and lie in the sphere of social and cultural life of society. Theoretical analysis. At certain points in history, the aggravation of social and cultural aspects of public life causes a change in the spiritual values developed over the centuries, followed by a revision of aesthetic ideals. In the period of the 1920s, youth became the dominant age category in the society, and the cult of youth appeared. The theoretical basis of this phenomenon was provided by T. Parsons, K. Mannheim, Х. Ortega-y-Gasset, J. Huizinga and others, justifying it by the conflict of generations, the lack of continuity between them. Conclusions. An attempt has been made to take an integrated approach to the analysis of a number of aspects of a socio-cultural nature in a certain time period, which served as the starting point for the emergence of the cult of youth. The phenomenon led to the reassessment of aesthetic ideals. Fashion reacted sensitively to it, youth images inspired bold new directions and determined its development for decades to come.
Escapism as a subject of philosophical reflection
Authors: Napso Marianna D. ,   North-Caucasus State Academy
Published: July 2024

Introduction. Technological transformations and the expanding processes of digitalisation, which have encompassed the space of an individual and social life, have given a new meaning to escapism as a form of existence and behavioural strategy. Virtual practices have become the most important component of life and activity of an individual and have created conditions that have strengthened escapist tendencies and moods. Theoretical analysis. The social phenomenon of escapism, including digital escapism, is the subject of interdisciplinary research due to the complexity and ambivalence of this phenomenon. In the centre of research interest there is the essence of escapism, the processes of formation of escapist consciousness and worldview, the influence of historical and social contexts on the evolution and demand for escapist practices. Conclusion. Escapism is a specific means of escape from the everyday life into the world of other-reality. The existing differences in assessments of the ideology of escapism allow us to reveal its contradictory nature, which consists in the presence of negative aspects that form the space of dependence (including digital), and positive components that contribute to the development of the sphere of imagination, thanks to which there is a deeper understanding of the true reality, awareness of its dominant role for the existence of an individual.
The problem of eligibility criteria in biomedical experiment: Philosophical and methodological analysis
Authors: Nartova Maria A. ,   Lomonosov Moscow State University
Published: July 2024

Introduction. The formation and development of modern evidence-based medicine is not possible without clinical studies with the participation of humans as subjects. The methodology of such experiments is based on careful selection of subjects based on the so-called eligibility criteria – parameters which form the optimal patient group for studying the therapeutic properties of a particular drug based on the science community’s expectations. The article considers some bioethical aspects of the practical problems of formulating such criteria, and also it examines the question of the possibility of proper application of scientific data obtained in the framework of clinical studies. Theoretical analysis. Based on the example of HIV-positive patients, it is shown that excessive formalization of the process of determining eligibility criteria leads to the formation of fundamental differences between participants in clinical trials and patients in routine medical practice, which put at risk the ability to properly extrapolate the results of such studies outside the experimental field and realization of one of the basic bioethical principles of clinical trials: to be useful for society. Conclusion. The article substantiates the need to revise the methodological and bioethical foundations of the process of formulating eligibility criteria, taking into account the risks faced by patients of experimental therapy and patients in real clinical practice.
A personal and social ideal according to the Teachings of St. Abba Dorotheus
Authors: Salov Petr Yu. ,   Religious Organization – Higher Theological Educational Organization of the Russian Orthodox Church “Saints Cyril and Methodius Institute for Postgraduate Studies”
Published: July 2024

Introduction. Christianity, which developed in special historical conditions on the territory of Byzantine Gaza, gradually formed a unique school of spiritual mentoring in the region, associated with the names of outstanding ascetics. At the same time, a regional ascetic literary tradition was developed. Theoretical analysis. Dorotheus of Gaza, an outstanding Christian teacher of the early Byzantine period, formulates his own critical view of contemporary social norms, human nature and the causes of human vices, contrasting them with the lifestyle of a Christian ascetic. Abba Dorotheus pays considerable attention to the psychology of spiritual development and the struggle with the passions. This article examines and summarizes the main motives in the teachings of Abba Dorotheus, through which he defines the personal and social ideal of Christian asceticism. Conclusions. It is concluded that the teachings of the saint Dorotheus of Gaza are aimed at the formation of not only a personal, but also a social ideal, and monasticism, as interpreted by Abba Dorotheus, is not an anti-social movement, but should contribute to the formation of a new, just community based on the principles of communitarianism and liturgical unity. It is emphasized that achieving this goal does not imply political, military or intellectual confrontation with the outside world.
Examining Dividend Policy as a Mediating Variable in Stock Price Trends: Evidence from the Indonesian Basic Materials
Authors: Nurmahfudi Dehan Azzahrah , Yuniningsih Yuniningsih
Published: July 2024

This research investigates the impact of financial ratios, including profitability, liquidity and solvency, on stock prices, with dividend policy as a mediator, in the Indonesian raw materials sector. The analysis covers 100 samples from 25 of companies listed on the Indonesia Stock Exchange (BEI) from 2019 to 2022. The research aims to explore stock price fluctuation trends and examine the relationship between financial ratios and stock prices, as well as the role of dividends policy in mediating this relationship. The findings show that profitability and liquidity are important factors in determining stock prices, while solvency does not influence stock prices, nor does dividend policy play an important role in mediating the relationship between variables. It is hoped that these findings will provide insight for investors, policy makers and industry stakeholders in navigating Indonesia's dynamic construction materials market.
The Effect of Corporate Governance and Profitability on Firm Value Mediated by Corporate Social Responsibility (CSR) Disclosure in Infrastructure, Utility, and Transportation Sector Companies Listed on the Indonesia Stock Exchange (IDX)
Authors: Melya Liza , Sakir Faisal, A
Published: July 2024

This study examines the corporate governance and profitability effect on firm value with Corporate Social Responsibility (CSR) disclosure as mediation in infrastructure, utilities, and transportation sector companies listed on the Indonesia Stock Exchange (IDX) for 2018-2022. To test the direct and indirect effects of factors affecting firm value, SEM-PLS analysis was used. The study discovered that corporate governance and CSR positively impact firm value. However, profitability does not have a significant effect on firm value. Additionally, corporate governance and profitability both have a positive influence on CSR. CSR can partially mediate the effect of corporate governance on firm value, and fully mediate the effect of profitability on firm value. The most commonly implemented aspects of CSR, based on Global Reporting Initiative (GRI) disclosure, are social, environmental, and economic, in that order. The findings suggest that companies that prioritize CSR, particularly environmental aspects, are more attractive to investors.
On Prospects for Improving Legal Regulation and Organization of Public Authority in the Field of Tourism in the Russian Federation. Legal Modeling Experience
Authors: Pisarevsky Evgeny L. ,   Deputy Head of the Financial Commissioner Support Service, Professor of the Basic Department of Inter-Branch Regulation
Published: July 2024

The publication is dedicated to the issues of raising the quality of the legal regulation and efficiency of the structure and operations of public government authorities in the tourism sphere in the Russian Federation. The article analyzes the main results of law-making activities, studies approaches towards systematization of laws on travel activities and proposals for improvement of public administration in the tourism sphere that have become the basis for corresponding conceptual models.
Tourism and Artificial Intelligence: The Legal Regulation in Russia and Kazakhstan
Authors: Ivanova Zhanna B. ,   Associate Professor of the Department of Legal Disciplines of the Komi Republican Academy of State Service and Administration, Tatarinova Lola F. ,   Associate Professor of the Department of Social Sciences and the Humanities of the University of International Business, PhD (Law)
Published: July 2024

"Fair and responsible artificial intelligence for consumers" became the Motto of consumer protection in 2024 and gave rise to research on the use of artificial intelligence in tourism in Russia and Kazakhstan. The authors pointed out the many advantages of introducing such modern technologies, as well as the problems of their legal regulation. In conclusion, it is concluded that travelers need confidence in the proper protection of their rights in the modern digital age. For this purpose, it is necessary to regulate the use of artificial intelligence at the doctrinal and legislative level.
Special Aspects of Organization of Environmental Tourism in the Region
Authors: Ivankovsky Sergey L. ,   Associate Professor of the Department of Corporate Economics, Ivankovskaya Natalya A. ,   Associate Professor of the Department of Management in Sports, Faculty of Physical Education and Sports of the National Research Lobachevsky State University of Nizhny Novgorod
Published: July 2024

and Sports of the National Research Lobachevsky State University of Nizhny Novgorod, PhD in Pedagogy, Associate Professor This article considers the peculiarities of ecological tourism development in the region on the example of Nizhny Novgorod region. The relevance of this publication lies in the assessment of tourist and recreational resources and the study of the potential of the created and formed special protected natural areas of the region. The paper presents the results of the experiment on activation of ecological and cognitive activity of students aimed at the expansion of ecological tourism. The authors believe that the most active part of ecotourism is the youth. Therefore, close attention is paid to this group. Tourism development programmes are given, according to which an eclectic development of ecotourism in Nizhny Novgorod region is proposed. To improve ecotourism it is proposed to use favourable factors of ecotourism of special protected natural areas and activation of cognitive and conscious attitude to nature. This is what the activities of government agencies should be aimed at.
Organizational, Legal and Methodological Aspects of Carrying Out Forensic Activities in the Republic of Moldova
Authors: Dronova Olga B. ,   Professor of the Department of Criminal Investigation Technique of the Academic Complex of Expert and Criminalistic Activities of the Volgograd Academy, Kubitski Alina V. ,   Junior Scientifi c Assistant of the Volgograd Academy of the Ministry of the Interior of the Russian Federation
Published: July 2024

The article reviews some organizational, legal and methodological aspects of performance of forensic activities in the Republic of Moldova. The described matters give an opportunity to obtain an idea about regulatory and technical requirements for carrying out forensic examination as the most in-demand form of using special knowledge in solution and investigation of crimes. The authors note some material diff erences from Russian analogues.
Classifi cation and Information Cells of Trace Cores
Authors: Bystryakov Evgeny N. ,   PhD (Law), Associate Professor, Usanov Igor V. ,   Associate Professor of the Department of Criminalistics of the Saratov State Law Academy, PhD (Law), Associate Professor
Published: July 2024

The article reviews the problems of the establishment of new understanding of the system of traces in Russian criminalistics. The authors suggest a classifi cation of "trace cores", which is a term introduced in the scholarly dispute, and analyze the content of "trace cores" (information cells). A classifi cation of "trace cores" will give practitioners a better understanding of what traces are to be searched for in the investigation of certain crime types. This will improve the crime investigation effi ciency.
Special Aspects of Diagnostics of the Criminal Conduct of People Convicted for Extremist Crimes and Serving a Sentence in Correctional Facilities
Authors: Kovalev Oleg G. ,   Chief Research Scientist of the Research Institute of the Federal Penitentiary Service of Russia, LL.D., PhD (Psychology), Professor, Agarkov Vyacheslav A. ,   Cadet of the Faculty of Psychology of the VILE of the FPS of Russia
Published: July 2024

The article analyzes some organizational and methodological aspects of the diagnosis of criminal behavior of extremist convicts serving sentences in correctional colonies. The features of psychological diagnosis and impact on convicts, representatives of various extremist organizations, criminal tactics used to spread extremist ideology in places of detention are considered. Based on the conducted theoretical and pilot empirical research, theoretical and applied approaches are proposed for the application of psychological knowledge by penitentiary psychologists, employees of services and departments of the penitentiary system in professional activities in the implementation of its most important task — ensuring security in institutions of the penal correction system, defined by the Concept of its development for the period up to 2030 (approved by the Decree of the Government of the Russian Federation dated 04/29/2021 No. 1138-R.).
Educational Programs and Methodological Errors of Their Design
Authors: Vilkova Alevtina V. ,   Deputy Head of the Federal State Institution Research Institute of the Federal Penitentiary Service of Russia, Fadeeva Svetlana A. , Polyakova Yanina N. ,   Chief Research Scientist of the Federal State Institution Research Institute of the Federal Penitentiary Service of Russia, Doctor of Pedagogy, Associate Professor,   Leading Research Scientist of the Federal State Institution Research Institute of the Federal Penitentiary Service of Russia, PhD (Psychology)
Published: July 2024

The article updates the development of working education programs in educational organizations in accordance with regulatory requirements and methodological recommendations; draws attention to the importance of a “seamless” educational space between levels of education; typical methodological errors arising during the design of educational programs in educational organizations are shown; emphasis is placed on the need to take into account the specifics and conditions of a particular organization when developing educational programs for students.