bluuebunny/crossref_metadata_2025 huggingface dataset:
Core Self-Evaluations, Perceived Job Characteristics and Job Satisfaction: Evidence from Two Independent Samples of Highly Skilled Argentinian Workers
Authors: Pujol-Cols Lucas
Published: March 2019

This study examined the mediating role of perceived job characteristics in the relationship between core self-evaluations (CSEs) and job satisfaction. Data were collected from two independent samples of highly skilled workers in Argentina (190 scholars and 116 managers). The results from the structural equation modeling analysis revealed that perceived job characteristics partly mediated the relationship between CSEs and job satisfaction in both samples (32% in sample 1 and 65% in sample 2), suggesting that those individuals with higher CSEs tended to perceive their jobs as more resourceful (i.e., more rewarding, secure, and supportive), which increased their levels of job satisfaction. ese findings were consistent with those reported in North-American and European organizational settings, which provided further support to the universality and cross-cultural generalizability of the CSE construct.
Pair-wise MHD-interaction of rigid spheres in longitudinal creeping flow
Authors: Boriskina Irina P. , Syromyasov Aleksei O.
Published: March 2019

Authors describe and study the mathematical model of two identical rigid spheres immersed in highly viscous fluid with magnetic field acting in it. At infinite distance from suspended particles the flow and the field are uniform. The hypothesis that bulk currents are weak allows to split magnetic and hydrodynamic interactions of the spheres. Distribution of magnetic field is obtained for arbitrary orientation of undisturbed field with respect to line going through the spheres' centers and is written in the form of multipole expansion. This expression is used to calculate magnetic force acting on both particles. Together with known expressions for hydrodynamic forces this result may be applied in study of particle dynamics in uniform flow of viscous magnetic fluid. In the paper particular case of field and flow being parallel to line of centers is examined in more detail. The opportunity of particles' coagulation in such flow is discussed.
First evidence of tick-borne protozoan pathogens, Babesia sp. and Hepatozoon canis, in red foxes (vulpes vulpes) in Serbia
Authors: Juwaid Salem , Sukara Ratko , Penezić Aleksandra , Mihaljica Darko , Veinović Gorana , Kavallieratos Nickolas G. , Ćirović Duško , Tomanović Snežana
Published: March 2019

Tick-borne haematozoans cause severe diseases in domestic animals, and some of them have zoonotic potential. The results of previous studies in Europe point to the important role of foxes in natural endemic cycles of several tick-borne pathogens, including protozoa. The aim of the present research was to acquire information on the prevalence and distribution of tick-borne protozoan parasites among foxes in Serbia. Legally hunted foxes from 14 localities throughout Serbia were analysed. Spleen samples were collected from 129 animals and tested for the presence of Babesia spp. and Hepatozoon spp. by PCR. In total, 79/129 (61.2%) of the tested foxes were positive for H. canis, while the presence of two Babesia species was confirmed: B. vulpes (37/129, 28.7%) and B. canis (1/129, 0.8%). Coinfection with B. vulpes and H. canis was present in 26/129 (20.2%) foxes and one animal (1/129, 0.8%) was co-infected by B. canis and H. canis. The results of this study indicate the important role of foxes in the epizootiology of B. vulpes and H. canis in the Republic of Serbia and stress the need for further research to clarify all elements of the enzootic cycle of the detected pathogens, including other reservoirs, vectors, and transmission routes.
Identification of neuropeptide Y in superior cervical ganglion neurons that project to the oesophagus – A combined immunohistochemical labelling and retrograde tracing study in pigs
Authors: Rytel Liliana , Snarska Anna , Gonkowski Slawomir , Wojtkiewicz Joanna , Szenci Ottó , Sobiech Przemyslaw
Published: March 2019

Neuropeptide Y (NPY) is a neuronal active substance taking part in the regulation of gastrointestinal (GI) tract activity. This study used retrograde neuronal tracing and immunofluorescence methods to analyse NPY-positive neurons located in superior cervical ganglion and supplying the cervical oesophagus in the pig. The presence of NPY was observed in 30% of all neurons supplying the part of oesophagus studied. Probably the number of Fast Blue (FB) positive cells depends on the area of the wall injected with FB and the fragment of oesophagus studied. Therefore, the obtained results indicate that the described peptide is an important factor in the extrinsic innervation of this part of the GI tract.
An extension of $z$-ideals and $z^\circ$-ideals
Authors: ALİABAD Ali Rezaei , BADİE Mehdi , NAZARİ Sajad
Published: March 2019

Let $R$ be a commutative ring, $Y\subseteq Spec(R)$ and $ h_Y(S)=\{P\in Y:S\subseteq P \}$, for every $S\subseteq R$. An ideal $I$ is said to be an $\mathcal{H}_Y$-ideal whenever it follows from $h_Y(a)\subseteq h_Y(b)$ and $a\in I$ that $b\in I$. A strong  $\mathcal{H}_Y$-ideal is defined in the same way by replacing an arbitrary finite set $F$ instead of the element $a$. In this paper these two classes of ideals (which are based on the spectrum of the ring $R$ and are a generalization of the well-known concepts semiprime ideal, z-ideal, $z^{\circ}$-ideal (d-ideal), sz-ideal and $sz^{\circ}$-ideal ($\xi$-ideal)) are studied. We show that the most important results about these concepts, Zariski topology", annihilator" and etc can be extended in such a way that the corresponding consequences seems to be trivial and useless. This comprehensive look helps to recognize the resemblances and differences of known concepts better.
Acentralizers of Abelian groups of rank 2
Authors: MOZAFAR Zahar , TAERİ Bijan
Published: March 2019

Let $G$ be a group. The Acentralizer of an automorphism $\alpha$ of $G$, is the subgroup of fixed points of $\alpha$, i.e.,  $C_G(\alpha)= \{g\in G \mid \alpha(g)=g\}$. We show that if $G$ is a  finite  Abelian  $p$-group of rank $2$, where $p$ is an odd prime, then the number of Acentralizers of $G$ is exactly the number of subgroups of $G$. More precisely, we show that for each  subgroup $U$ of $G$, there exists an automorphism $\alpha$ of $G$ such that $C_G(\alpha)=U$. Also we find the Acentralizers of infinite two-generator Abelian groups.
In Memory of the Maple Syrup Man
Authors: Close Julia
Published: March 2019

This narrative, written in memory of a cancer patient, considers the emotional aspects of bringing your work home with you as an oncologist.
The Quest for an Ideal Neoadjuvant Systemic Therapy in Cisplatin-Ineligible Patients with Muscle-Invasive Localized Urothelial Carcinoma
Authors: Swami Umang , Grivas Petros , Agarwal Neeraj
Published: March 2019

This commentary reviews current progress in neoadjuvant immunotherapy for muscle-invasive localized urothelial carcinoma, highlighting opportunities and challenges with recent neoadjuvant immunotherapy trials.
Driving under the Influence of Alcohol - Epidemiological Profile of the Victims in Mato Grosso State, Midwest Brazil
Authors: Marilene Neves  , Larissa Rosa Dias Faustino  , Jozeilton Dantas Bandeira  , Jaime Trevizan Teixeira  , Alexandre Silva Brasil  , Heitor Simões Dutra Corrêa  , Eguiberto Bernardes Fraga Júnior  , Elisangela Santana De Oliveira Dantas  , Diniz Pereira Leite Júnior
Published: March 2019

Blood Alcohol Concentration (BAC) refers to the amount of ethanol present in the blood of an individual. Ethanol is among the most common substances encountered in forensic toxicology because ethanol abuse is related to fatal traffic accidents and general anti-social behavior. The objective was to describe the profile of victims of fatal traffic accidents in the state of Mato Grosso between 2013 and 2015. We analyzed 3,045 case records from Mato Grosso state Official Public Forensic Institution, Politec. Positive results for the presence of ethanol in the blood of victims of fatal traffic accidents was higher for males 1,162 (83.1%), from 21 to 30 years of age, and occurred predominantly during the weekends. Traffic accidents in Cuiabá County had the highest mortality coefficient per 100 thousand inhabitants (28.9%) than the rest of the state. Regarding the months of the year, there was a homogenous distribution with a discrete predominance of cases in October, November and December. The incidents were more frequent between 22h, 8h and 11h/12h am. This study contributes not only for the identification of the individuals most likely to be involved in traffic accidents where ethanol was consumed, but also to subsidize public policies aimed towards intervening and raising awareness of damages due to association among driving and ethanol use or abuse.
Measurement of free-flow conditions on multilane intercity highways under heterogeneous traffic conditions
Authors: Boora A , Ghosh I , Chandra S , Rani K
Published: March 2019

Vehicles travelling at their desired speed under free-flow conditions (FFC) on a highway without getting influenced by other vehicle types travelling in the same lane exhibit a good level of service (LOS) on that particular highway facility. Few studies could be identified that provide guidelines on the measurement of FFC on multilane highways, including the latest version of the United States' Highway Capacity Manual (TRB 2010). As these guidelines are mostly based on homogeneous traffic conditions, they may or may not be applicable to heterogeneous traffic conditions. Previously used methodologies (for two-lane and multilane highways) were examined in the current study, but were found to be unsuitable for multilane highways. Therefore a new measure, named speed difference (SD), was introduced in the present study. SD is the difference in speed of two consecutive vehicles travelling in the same lane. A relationship was established between SD and gap (the difference between two consecutive vehicles from back to front bumper while travelling in the same lane), instead of headway (the difference between two consecutive vehicles from back to back or front to front bumper while travelling in the same lane). A gap value of 10 seconds was identified, beyond which vehicles would be travelling in FFC. The guidelines proposed in the present study will be helpful for traffic engineers and planners in developing countries.
PUBLICACIÓN CIENTÍFICA Y CARACTERÍSTICAS DE ASESORES DE TESIS DE UNA ESCUELA DE PSICOLOGÍA PERUANA
Authors: Mamani Benito Oscar J.
Published: March 2019

El objetivo de la presente fue describir las características de los asesores de tesis de pregrado en una escuela de psicología y analizar su producción científica. La metodología implica un estudio de tipo descriptivo-bibliométrico, donde la población estuvo constituida por 37 docentes asesores de 149 trabajos de pregrado aprobados en una universidad privada del Perú, los mismos que fueron ubicados en el repositorio digital de dicha institución y aprobados en el periodo 2014 – 2017. Los principales resultados indican que hubo una mayor participación de asesores mujeres (70.3%) que varones (29.7%), además, el 64.9% evidencia tener solo título profesional, el 21.6% grado de magister y tan solo un 13.5% grado de doctor, así mismo, solo el 27% evidencia publicaciones científicas en Google Académico, mientras que el 73% no publicó alguna vez en su vida; finalmente, se halló una producción científica de 37 artículos (33 originales, 2 cartas al editor y 2 editoriales) correspondientes a 10 docentes asesores, en revistas nacionales e internacionales. Se concluye que los asesores de tesis de pregrado en psicología tienen una preocupante y baja producción científica.
EXPERIENCIAS E IMPACTO SOCIAL EN LA APLICACIÓN DE INGENIERÍA DE REQUISITOS EN EL DESARROLLO DE UNA PLATAFORMA INTELIGENTE
Authors: Maquera Gladys , Mariaca Jesús , Mendoza Óscar , Condori Fernandez Nelly
Published: March 2019

El turismo rural comunitario (TRC) es una actividad que contribuye, desde las zonas rurales, al desarrollo económico-social y sostenible de un país. En este trabajo de investigación se tuvo como objetivo desarrollar una Plataforma Inteligente (PI) que satisfaga las necesidades de los distintos actores del TRC. Se presenta la experiencia centrada en Ingeniería de requerimientos, pasando por distintas iteraciones, donde se realizó el análisis FODA, uso de la programación extrema, cumplimiento de la ISO 25010, entre otros. La identificación precisa de los requerimientos fue determinante para que la implementación y usabilidad de la plataforma tenga un impacto social en los actores directos.
LA FORMACIÓN DEL CARÁCTER EN EL PENSAMIENTO DE ELENA G. DE WHITE: UNA PERSPECTIVA DE EDUCACIÓN INTEGRAL
Authors: Martinez Tejada Victoria
Published: March 2019

El estudio del carácter es un tema vigente para los educadores, porque a partir de ello se construyen los lineamientos curriculares de los diversos programas de formación educativa que en todos sus niveles buscan la educación integral.  A fin de tener una dirección clara en cuanto al carácter y su formación, se hizo necesario desarrollar una investigación de enfoque cualitativo, con un diseño de investigación yuxtapuesto de teoría fundamentada emergente y narrativa, para conocer el pensamiento de Elena G. De White con respecto a este tópico a lo largo de sus escritos (1844 – 1915).
CLIMA SOCIAL FAMILIAR Y RESILIENCIA EN ESTUDIANTES DE 3°, 4° Y 5° AÑO DE SECUNDARIA
Authors: Moya Lozano María Elena , Cunza Aranzábal Denis Frank
Published: March 2019

El objetivo de este artículo es determinar la relación que existe entre el clima social familiar en sus tres dimensiones y la resiliencia en los estudiantes de tercero, cuarto y quinto año del nivel secundario de una corporación educativa del norte del Perú. El estudio realizado fue de corte transversal y alcance descriptivo-correlacional, con una población de 394 estudiantes de 13 a 19 años. Los instrumentos utilizados fueron la Escala de Clima Social Familiar FES de Moos y la Escala de Resiliencia (ER) de Wagnild y Young. Los resultados obtenidos demuestran que existe relación entre el clima social familiar y la resiliencia (rs =.175, p <.05). Asimismo, la dimensión del clima social familiar “relaciones interpersonales” presenta una correlación significativa (rs =.123, p <.05) y “desarrollo personal” muestra una correlación altamente significativa con la “resiliencia” (rs =.211, p <.01). Sin embargo, la dimensión “estabilidad” y la “resiliencia” no presentan correlación significativa. A partir de los datos analizados se concluye que el clima social familiar se encuentra asociado con la resiliencia en los adolescentes de la población estudiada.
Offene Big-Data-Plattform für Industrie 4.0
Authors: Weskamp Jan Nicolas , Poudel Bal Krishna , Al-Gumaei Khaled , Pethig Florian
Published: March 2019

Durch zunehmend preiswertere Geräte, günstige Internettechnologien, hochleistungsfähige mobile Geräte sowie Low-Cost-Sensoren hat sich die Menge von vernetzten Geräten drastisch erhöht und wächst weiter. Diese Geräte generieren enorme Datenmengen, die in Echtzeit überall im Unternehmen oder sogar unternehmensübergreifend verfügbar sein sollen. Die Nutzung großer Datenmengen in neuen Geschäftsmodellen und zur Optimierung von Produkten und Produktion wird auch als vierte industrielle Revolution (Industrie 4.0) bezeichnet [1]. Große Datenmengen in Echtzeit global im Unternehmen verfügbar zu machen ist eine Anforderung für die sich herkömmliche IT-Systeme und Tools für industrielle Datensammlung, -transport, -speicherung und -analyse nur bedingt eignen. Dieser Beitrag stellt eineoffene Big-Data-Plattform auf Basis aktueller Technologien, Umsetzungen und Konzepten wie der OPC Unified Architecture (OPC UA), der Industrie-4.0-Verwaltungsschale, Apache Kafka und verteilten Datenanalyseframeworks wie Apache Spark vor.
CORONARY ARTERY STENOSIS: IS REVASCULARIZATION ALWAYS REASONABLE?
Authors: Korotin A. S. , Posnenkova O. M. , Kiselev A. R. , Popova Yu. V. , Gridnev V. I.
Published: March 2019

Aim.To determine factors associated with percutaneous coronary intervention (PCI) and/ or coronary artery bypass grafting (CABG) in patients with stable coronary artery disease (CAD), who have no indications for myocardial revascularization.

Methods.The data were collected using the Federal CAD Registry. Medical data of 1522 patients with CAD were reviewed. Of them, 326 patients (median age – 54.7±8.7 years; 73.0% – males) who had no indications for PCI and CABG according to 2013 ESC guidelines on stable CAD (ESC 2014) were analyzed.

Results.216 patients out of 326 (66%) patients received medical treatment. The rest 110 patients (34%) without any recommended indications underwent myocardial revascularization. Discriminate analysis determined coronary artery stenosis of >70% was the only factor reliably associated with the decision to perform myocardial revascularization in the absence of any indications (р<0.001). Almost 93% of the interventions were performed in asymptomatic patients or patients with mild angina.

Conclusion. Patients with stable CAD without any objective indications for coronary intervention may be unreasonably referred to myocardial revascularization (commonly PCI) due to coronary artery stenosis >70% regardless of whether they have or do not have angina symptoms.
CHALLENGES OF DIAGNOSIS OF OBSTRUCTIVE CORONARY ARTERY DISEASE: THE ROLE OF NON-INVASIVE TESTING
Authors: Korok E. V. , Sumin A. N.
Published: March 2019

High mortality from cardiovascular diseases, especially coronary artery disease (CAD), represents a major economic burden on healthcare systems. The number of diagnostic coronary angiographies (CAG) is increasing in the Russian Federation. However, routine invasive CAG is not able to determine obstructive coronary artery disease in a considerable number of patients. The rate of intact coronary arteries reaches 42% in the major registries and accounts for 37.9% in our Research Institute. Despite all improvements in the diagnostic algorithms focused on suspected coronary artery disease, stated in the recent international and national guidelines, and the availability of advanced non-invasive diagnostic methods, they do not improve accurate CAG diagnosis of obstructive coronary artery disease. Moreover, the available guidelines contain many contradictions. Therefore, an optimal diagnostic algorithm of significant coronary artery lesions is a subject of discussion. The proposed review discusses all discrepancies concerning the assessment of the pretest probability as well as the proposed non-invasive testing. In addition, the preferred use of non-invasive tests with anatomical assessment (i.e. multispiral computed tomography coronary imaging) rather than functional tests with visualization is stated. This review ensures better understanding of diagnostic strategies for stable coronary artery disease used both in researches and in clinical practice.
Clinical and methodological aspects in the diagnosis of magnesium deficiency in patients with paroxysmal atrial fibrillation
Authors: Bozhko Ya G , Arkhipov M V , Belokonova N A , Kiseleva D V
Published: March 2019

Aim. To determine magnesium deficiency in patients with paroxysmal atrial fibrillation using a comprehensive clinical and laboratory approach. Methods. The prospective cohort study included 35 patients of the cardiology department of the Medical association «Novaya bolnitsa». The main group consisted of 22 patients with frequently recurrent paroxysmal atrial fibrillation, the control group - 13 patients without cardiac arrhythmias. The clinical status, Holter-monitoring of the electrocardiogram, the results of the clinical test for magnesium deficiency, laboratory parameters of calcium, magnesium in blood plasma and formed elements, magnesium in whole blood, free fatty acids and plasma osmolarity were evaluated. Results. The clinical score of magnesium deficiency was significantly higher in patients from the main group compared to the control [16.5 (11÷21) vs 13 (8÷15), p <0.001]. In the main group, there was a decrease of magnesium in the whole blood [0.55 (0.5÷0.59) vs 0.61 (0.58÷0.54), p=0.002] and inside the blood cells [0.68 (0.53÷1.29) vs 1.38 (1.29÷1.44), p <0.001]. In patients with atrial fibrillation there is a shift of the ratio of calcium to magnesium in blood plasma [2.5 (2.5÷3) vs 2.9 (2.8÷3.15), p=0.029] and intracellularly [4.85 (2.62÷9.3) vs 1.7 (1.4÷1.95), p=0.002]. The redistribution of calcium and magnesium is influenced not only by the initial concentration of cations, but also by free fatty acids. The best redistribution was obtained when the concentration of free fatty acids was 900 µmol/l, magnesium 1 mmol/l, and calcium 3 mmol/l, which is consistent with the optimal value of cations in the blood plasma. Conclusion. Patients with paroxysmal atrial fibrillation had a significantly lower magnesium content in whole blood and inside the blood cells; magnesium concentration in the cells and in whole blood closely correlated with the results of the clinical test for evaluating magnesium deficiency; intracellular magnesium content can be influenced by the complexing interaction with free fatty acids.
The relationship of cytokine status with left ventricular hypertrophy in patients with arterial hypertension
Authors: Zalova T B , Polupanov A G , Tsoy L G , Rysmatova F T , Sabirov I S
Published: March 2019

Aim. To study the relationship of tumor necrosis factor α and interleukin-10 levels with the presence of left ventricular hypertrophy and myocardial remodeling in patients with arterial hypertension. Metods. 156 patients with hypertension aged 40 to 75 years (mean age 55.8±7.5 years), including 57 women and 99 men were examined. All patients were divided into two groups. Group 1 included 83 patients without left ventricular hypertrophy (55.5±7.5 years), group 2 included 73 patients with left ventricular hypertrophy (56.2±7.8 years), established by echocardiographic signs. All patients in addition to the general clinical examination and biochemical studies had echocardiography and Doppler echocardiography performed, as well as measurement of the concentration of tumor necrosis factor α and interleukin-10 by solid-phase enzyme immunoassay using specialized «Cytokine-Stimulus-Best» kit (Novosibirsk, Russia). Results. The concentration of tumor necrosis factor α in patients without left ventricular hypertrophy was 8.43±1.36 pg/ml and was comparable with the concentration of this cytokine in patients with left ventricular hypertrophy (8.54±1.58 pg/ml, p >0.05). This pattern was typical for both men and women. The concentration of interleukin-10 in both groups was also comparable (15.4±3.6 pg/ml in group 1 and 14.7±3.4 pg/ml in group 2, p >0.05). However, we identified gender-specific features in the relationship of interleukin-10 with the presence of left ventricular hypertrophy in patients with hypertension. Thus, while in women the concentration of cytokine in groups with/without left ventricular hypertrophy did not differ significantly, in men without hypertrophy the level of interleukin-10 of 15.7±3.6 pg/ml, was significantly higher than the value of the same indicator in the group of men with left ventricular hypertrophy (14.8±2.9 pg/ml, p <0.025). Multivariate regression analysis showed that tumor necrosis factor α and interleukin-10 concentrations correlated to left ventricular wall thickness in patients without left ventricular hypertrophy. No such pattern was revealed for patients with hypertrophy. Conclusion. The results demonstrate the modulating role of tumor necrosis factor α and interleukin-10 in myocardial remodeling processes in arterial hypertension.
Time-dependent systemic hemostatic effects of fibrin monomer in controlled liver injury in the experiment
Authors: Vdovin V M , Momot A P , Orekhov D A , Tolstokorov I G , Shevchenko V O , Krasyukova V O , Shakhmatov I I , Lycheva N A , Belozerskaya G G
Published: March 2019

Aim. To evaluate the hemostatic effect of fibrin monomer after its intravenous administration at different time periods in experimental trauma. Methods. In the experiments, in a placebo-controlled study, hemostatic and hemostasiological effects of systemic use of fibrin monomer were studied at different time periods after its administration (in 5 min, 1 h and 3 h) in 97 male rabbits of the Chinchilla breed in the controlled liver injury model. Results. A pronounced hemostatic effect was demonstrated for fibrin monomer used at a dose of 0.25 mg/kg demonstrated by a 6.3-fold decrease of blood loss volume (% of circulating blood volume) compared to placebo on the background of the intravenous preventive fibrin monomer administration 1 hour prior to controlled liver injury. Fibrin monomer administration at a stated dose was not accompanied by significant changes in haemocoagulative parameters including measurement of platelet count, activated partial thromboplastin time, prothrombin time, thrombin time, echitox time, fibrinogen concentration, level of soluble fibrin monomer complexes, D-dimer content, and antithrombin III activity. The effect of fibrin monomer is probably realized through some effectors, the nature of which has not yet been studied. The obtained results allow choosing the optimal interval between intravenous administrations of fibrin monomer and controlled liver injury for further study of the mechanisms of its hemostatic action. Conclusion. Fibrin monomer in small doses (0.25 mg/kg) is able to exert a pronounced hemostatic effect with its systemic administration 1 hour prior to the injury without significant changes in haemocoagulative parameters.
Ovarian hyperstemulation syndrome as a private case of iatrogenic capillary leak syndrome
Authors: Kraevaya E E , Petrosyan Ya A , Tapil'skaya N I
Published: March 2019

Idiopathic capillary leak syndrome was first described in 1960 and later received its name in honor of the discoverer - Clarkson's Disease. However, in the past two decades, more cases have been reported than in the previous 35 years, most likely due to improved recognition, the widespread use of assisted reproductive technologies in the treatment of infertility and the emergence of targer therapy - monoclonal antibodies for the treatment of cancer and autoimmune diseases. Except for Clarkson's disease, capillary leak syndrome can occur in engraftment syndrome, differentiation syndrome after bone marrow transplantation, ovarian hyperstimulation syndrome, hemophagocytic lymphohistiocytosis, viral infections, mostly hemorrhagic fevers, some autoimmune diseases, administration of recombinant interleukins, cytostatics, some monoclonal antibodies including treatment with the latest anticancer drugs - immune checkpoint inhibitors, snakebite envenomation, and ricin poisoning. This syndrome is characterized by a sharp increase in vascular permeability for fluid and protein molecules that leads to the loss of fluid into the interstitium, and presents with acute onset of severe edema, often asymmetric, hypotension, polyserositis, hemoconcentration and low blood protein level. In assisted reproductive technology programs, the introduction of gonadotropins results in an increase in estradiol levels, which leads to the development of immunopathological process, accompanied by leukocyte infiltration of blood vessels and secondary hypercytokinemia. Subsequently, the secondary «wave» of cytokines and vasoactive substances secreted in response to the introduction of human chorionic gonadotropin as an ovulation trigger, leads to disruption of interendothelial contacts and the development of ovarian hyperstimulation syndrome. It is necessary to conduct a further study of the pathogenesis of capillary leak syndrome, in order to develop promising methods for the prevention and correction of ovarian hyperstimulation syndrome in assisted reproductive technology programs.
Adrenal incidentaloma: management of patients with functionally autonomous cortisol synthesis
Authors: Chzhen T R , Kiseleva T P , Torosyan M R
Published: March 2019

Over recent decades due to improved visualization (ultrasound, computer tomography and magnetic resonance imaging) prevalence of adrenal incidentaloma has increased. The term «adrenal incidentaloma» is generic and includes a group of tumors of various morphology and over 1 cm in diameter accidentally discovered during radiologic investigation. The found tumor can be hormonally inactive or actively releasing different hormones, malignant or benign, and originating from different adrenal zones or having non-specific organ origin. Based on the frequency of revealing and clinical significance the most noteworthy is functionally autonomous cortisol synthesis. It means changes of hypothalamic pituitary adrenal axis without classic clinically prominent signs of cortisol excess such as proximal myopathy, stretch marks, body fat redistribution and other metabolic changes related to cortisol. Currently a large number of recommendations on the management and tactics of treatment of adrenal incidentaloma can be found in the literature. Based on the analysis of these guidelines the conclusions were made about the diagnostic errors and incorrect approaches to the choice of treatment of such patients. Recently a lot of studies have been directed to the early detection of carbohydrate and lipid metabolism disorders, relation with obesity and type 2 diabetes mellitus, arterial hypertension and osteoporosis for preserved quality of life of such patients. Influence of hypercorticism is considered to worsen the course of these conditions but at the moment no effect of adrenalectomy on mortality and life duration was confirmed.
Clinical significance of left ventricular longitudinal deformation in coronary heart disease and non-coronary pathology
Authors: Akramova E G
Published: March 2019

The values of the global longitudinal systolic deformation of the left ventricle have sufficiently high diagnostic informativeness, preceding the reduction of the left ventricular ejection fraction, local contractility and increase of troponins. Its indicators reflect the early deformation disorders not only in coronary heart disease, but can serve as a sensitive parameter of the formation of systolic dysfunction in diseases of any origin. The study of the global deformation of the left ventricle with the preservation of traditional echocardiographic parameters within the norm (ejection fraction, local contractility, wall thickness, valve status, diastolic function, etc.) allows identifying a risk group for the subsequent targeted search for signs of coronary atherosclerosis. The sensitivity and specificity of longitudinal deformation by speckle-tracking echocardiography in the verification of myocarditis and cardiomyopathies are higher than those of magnetic resonance imaging. The prognostic value of the levels of deformation in the short and long term in relation to rehospitalization and death due to the progression of heart failure is proved. Dynamic observation of the global longitudinal deformation allows revealing the side cardiotoxic effects of drugs in patients with cancer and rheumatic diseases. Numerous studies show that the values of global longitudinal deformation in healthy individuals vary from -18 to -25% depending on the calculation program used, distinguishing this parameter from a number of other ultrasonic parameters. Illustrative color marking of numerical values of segmental systolic deformation of the left ventricle in the form of a «bull's eye» is much less reproducible than the value of the officially recommended global deformation. The differences in global and segmental longitudinal strain thresholds due to ultrasound scanner software and the lack of standardized clinical observations and statistical generalizations should stimulate further research in this area.
The experience of pancreas transplantation with isolated splenic artery supply
Authors: Pinchuk A V , Anisimov Yu A , Dmitriev I V , Storozhev R V , Balkarov A G , Muslimov R Sh , Khodilina I V
Published: March 2019

Aim. To demonstrate the possibility of successful transplantation of pancreaticoduodenal complex with isolated splenic artery supply and to assess the quality of its perfusion. Methods. 6 patients who underwent pancreas transplantation with isolated splenic artery blood supply were examined. The recipients were 3 men and 3 women, the median age was 36.5 [31; 42] years. To evaluate the state, quality of transplant perfusion and their function, the laboratory data, doppler ultrasound, measurement of blood flow volume (CT-perfusion) and treatment outcomes were assessed. Results. Based on the results of investigations, adequate pancreatic graft blood supply through the splenic artery alone was detected. Pancreatic transplant function in all patients was satisfactory, blood glucose levels remained within normal values. Hospital mortality was 0%. Conclusion. Successful transplantation of pancreaticoduodenal complex with isolated splenic artery supply is technically possible due to the presence of intraorganic arterial collaterals.
The experience of radiofrequency ablation of atrial tachycardia focus with the use of high-density myocardial mapping
Authors: Omelyanenko A S , Mavlyudov T I , Sapelnikov O V , Cherkashin D I , Islamova I M , Nasibullina A R
Published: March 2019

The article presents a case of successful treatment of focal atrial tachycardia by radiofrequency ablation using high-density myocardial mapping. The aim of the work was to evaluate the possibilities of high-resolution myocardial mapping by EnsitePrecision® navigation system in the treatment of complex arrhythmias. The analysis of clinical data and results of electrophysiological examination of a 29-year-old patient with continuous recurrent focal atrial tachycardia was carried out. The patient was admitted with complaints of heart rate disorders and frequent short attacks of palpitations. According to electrocardiography, frequent short paroxysms of focal atrial tachycardia were revealed. The patient was taken for electrophysiological examination and radiofrequency ablation of the focus of atrial tachycardia. The focus of atrial tachycardia was located in the anterior septal part of the left atrium, which is a rare localization. After radiofrequency ablation tachycardia was terminated, no complications and recurrences were registered. The patient was discharged with the sinus rhythm. Navigation system EnsitePrecision® enables conducting high-density myocardial mapping, which helps to accurately determine the localization of the source of tachycardia. The radiation load on the patient and ablation time are reduced, which reduces the frequency of complications from the procedure.
Application of adaptive tools in relaparotomy wound surgery
Authors: Izmaylov S G , Ryabkov M G , Leont’ev A E , Beschastnov V V , Izmaylov A G , Lukoyanychev E E
Published: March 2019

Aim. To evaluate the clinical effectiveness of the developed adaptive tools for mechanical treatment of wound surface and suturing of relaparotomy wounds. Methods. 55 patients aged 43 to 79 years after relaparotomy operated on for various acute surgical diseases of the abdominal cavity were treated. In the main group (n=22. average age 63.5±4.75 years) in uncomplicated and complicated course of the wound process after relaparotomy for treatment of the wound surface and wound closure, adaptive tools were used as proposed by the authors. In the comparison group (n=33, average age 62±6 years; p=0.98) traditional mechanical methods of wound defect sanation and wound suturing (simple nodal, 8-shaped and U-shaped sutures) were used. Monitoring of relaparotomy wound healing was performed using an ultrasound method. The analysis of postoperative local complications in the discussed groups of patients was carried out according to Clavien-Dindo classification. Results. In patients of the main group, the multiplicity of wound surface treatment decreased by 1.8 times compared to the comparison group. There were no cases of damage to the underlying tissues of the wound edges. Wound postoperative complications corresponded to severity grade I, II, and IIIa according to Clavien-Dindo classification: in the main group - 27.3% and in the comparison group - 54.5%. Suppuration occurred respectively in 9.1 and 33.3% of patients (p=0.049). Conclusion. The developed adaptive tools are safe and effective mechanical means of prevention of wound postoperative complications after relaparotomy.
80th anniversary of the department of maxillofacial surgery and surgical dentistry in Kazan state medical university
Authors: Ksembaev S S , Torgashova O E , Ivanov O A
Published: March 2019

The article highlights the main stages of formation and development of the Department of maxillofacial surgery and surgical dentistry of Kazan state medical University in 80 years of its activity. The article presents the information about the employees of the Department, starting from the first head of the Department associate professor I.M. Utrobin, the main directions of scientific research conducted under the leadership of the heads of the Department, the results of teaching, research and medical work. Special attention is paid to the achievements and contribution of the department staff to the clinical practice and work of the basic department of maxillofacial surgery in Kazan. The history of higher dental education in Kazan and training of specialists is inextricably linked with the activities of the department, whose representatives have made a significant contribution to the development of the national scientific school of dentistry and practical health care. The study of the history of maxillofacial surgery and surgical dentistry in Kazan, the study of ways and directions of its development, the study of the activity of the heads of the department, their achievements and scientific schools created by them, have traditionally been of interest not only among historians of medicine, specialists of surgical dental profile, as well as students of dental faculties, who decided to devote themselves to maxillofacial surgery or surgical dentistry. Today we are deeply grateful and proud to honor the memory of our teachers and predecessors, those who created Kazan dental school in the period of its formation and rapid development from the beginning of the 20th century to the present day by their glorious work and scientific discoveries.
Para um capítulo do teatro político no norte do Paraná a partir dos anos 1980: Bodas de café (1984) e Medidas contra a violência (2006)
Authors: Pascolati Sonia , Flory Alexandre
Published: March 2019

A história do teatro nacional tem sido escrita a partir do epicentro Rio-São Paulo, negligenciando a riqueza e diversidade de produções fora desse eixo, lacuna que a pesquisa em dramaturgia e teatro tem tentado preencher. Neste artigo, propomos uma reflexão sobre a importância da dramaturgia e do teatro norte-paranaenses a partir de dois grupos de teatro – o PROTEU, Projeto de Teatro Experimental Universitário, de Londrina, e o TUM, Teatro Universitário de Maringá –, analisando produções com clara visada política e que dialogam com o pensamento de um dos maiores homens de teatro do século XX, Bertolt Brecht, criando obras inovadoras em termos formais e temáticos que contribuíram para o desenvolvimento de um teatro crítico, tanto em âmbito regional como nacional.
ANDERMANN, Jens. Tierras en Trance: arte y naturaleza Después del paisaje. Santiago de Chile: Ediciones Metales Pesados, 2018. 462 p.
Authors: Souza Eneida Maria de
Published: March 2019

ANDERMANN, Jens. Tierras en trance: arte y naturaleza después del paisaje. Santiago de Chile: Ediciones Metales Pesados, 2018. 462 p.
travessia de um herói problemático
Authors: Oliveira Aryanna dos Santos , Silva Rosely de Fátima
Published: March 2019

Resumo: O ensaio pretende explanar sobre a travessia de Riobaldo em Grande sertão: veredas, como modelar do herói problemático na concepção proposta por Lukács, em A Teoria do Romance, através do estudo do episódio do (suposto) pacto demoníaco empreendido pelo protagonista da obra de Guimarães Rosa, nas Veredas-Mortas, feito que conduz a trajetória do herói por entre dúvidas e questionamentos, inerentes ao modelo lukacsiano. O estudo da obra rosiana será realizado por meio de análise comparativa com o pacto demoníaco realizado por Fausto, na obra homônima de Goethe, e de trechos de outras obras derivadas do tema do pacto demoníaco, como Dr. Fausto, de Thomas Mann e O mestre e Margarida, de Mikhail Bulgákov.Palavras-Chave: Grande sertão: veredas; Guimarães Rosa; Fausto; herói problemático; herói trágico; Lukács; pacto fáustico; pacto demoníaco.Abstract: The essay intends to explain the crossing of Riobaldo in Grande Sertão: Veredas as a model of the problematic hero in the conception proposed by Lukács in The Theory of the Novel, studying the episode of the (supposed) demonic pact undertaken by the protagonist of Guimarães Rosa’s novel, in “Veredas-Mortas”, moment that leads the trajectory of the hero through doubts and questions inherent to the Luckacsian model. The study over Rosa’s work will be carried out by comparative analysis with the demonic pact made by Faust, in the homonymous work of Goethe, and excerpts from other works derived from the theme of the demonic pact, such as Thomas Mann’s Doktor Faustus and Mikhail Bulgakov’s Master and Margarita.Keywords: Grande Sertão: Veredas; The Devil To Pay In The Backlands; Guimarães Rosa; Faust; problematic hero; tragic hero; Lukács; faustian pact; demonic pact.
diabo encerrado nos causos
Authors: Atroch Daniel Cavalcanti
Published: March 2019

Resumo: Este artigo propõe uma leitura do pacto diabólico no Grande sertão: veredas a partir de alguns dos numerosos “causos” que perpassam a narrativa, cuja constante são as “trocas de destino” ou “conversões existenciais” que se dão de forma assimétrica: um indivíduo de caráter ou condição social dominante imputa os reveses de sua sina a um subordinado. As ligações entre as estórias paralelas e o macrocosmo do livro vão na esteira de estudos de Todorov e de críticos que se ocuparam do tema no romance de Guimarães Rosa, como Davi Arrigucci Jr, Kathrin Rosenfield, Marcus Mazzari etc. Também são feitas considerações acerca da confiabilidade do relato riobaldiano e do seu viés “metaficcional”, a partir dos estudos literários de Jacques Rancière.Palavras-chave: Literatura brasileira; Grande sertão: veredas; João Guimarães Rosa.Abstract: We propose a reading of the devilish pact in Grande sertão: veredas, from some of the numerous tales that perpass the narrative, whose constant are the “exchanges of destiny” or “existential conversions” that occur asymmetrically: an individual with dominant character or social condition imposes his setbacks fate to a subordinate. The links between the parallel stories and the macrocosm of the book go in Todorov’s wake and critics They have dealt with the theme in Guimarães Rosa’s novel, such as Davi Arrigucci Jr, Kathrin Rosenfield, Marcus Mazzari etc. Considerations are also made about the reliability of Riobaldian’s narrative and his “metafictional” feature, based on Jacques Rancière’s literary studies.Keywords: Brazilian literature; Grande sertão: veredas; João Guimarães Rosa.
República de Riobaldo
Authors: Mapurunga Marcela Macedo Diniz , Cornelli Gabriele
Published: March 2019

Resumo: O presente artigo analisa o romance Grande Sertão: Veredas, de João Guimarães Rosa, e a República, de Platão, para promover um diálogo entre a “cidade da religião” e a kallipolis, a “bela cidade”, ambas discursivamente construídas pelos personagens Riobaldo, protagonista do romance de Rosa, e Sócrates, figura central do diálogo platônico; com o intuito de refletir sobre a necessidade urgente de um “novo homem” e uma “nova sociedade”, expressas por essas duas importantes obras. Ambas revelam uma tensão dramática: o sertão e a polis encontram-se em estado de confusão e injustiça e é preciso imaginar um outro lugar em que seja possível para o homem cuidar de sua alma.Palavras-chave: Guimarães Rosa; Platão; Grande Sertão: Veredas; República; Literatura e filosofia.Abstract: This paper analyzes the novel Grande Sertão: Veredas, by João Guimarães Rosa, and Plato’s Republic, to promote a dialogue between the “city of religion” and the kallipolis, the “Beautiful city”, both discursively built by Riobaldo, Rosa’s novel main character, and Socrates; It aims to reflect on the claim of the urgent need of a “new man” and a “new society”, expressed by these two important works. Both show a dramatic tension: the sertão and the polis are in a state of disarrangement and injustice and it is necessary to imagine another place where it could be possible for humankind to take care of the soul.Keywords: Guimarães Rosa; Plato; Grande Sertão: Veredas; Republic (Politeia); Literature and philosophy.
Narrativas de vários sertões
Authors: Cardoso Marília Rothier
Published: March 2019

Resumo: O objetivo deste artigo é estudar as narrativas de Guimarães Rosa como construção de uma linguagem poética que abre novas perspectivas ao pensamento, distanciando-se dos parâmetros da racionalidade ocidental. Como estratégia analítica, desenvolve-se um paralelo entre a estória rosiana do menino Miguilim e o relato autobiográfico do africanista Amadou Hampâté Bâ, com atenção para os capítulos referentes a seus tempos de criança. Nas duas narrativas, observa-se a conjugação de aspectos sobreviventes de culturas orais arcaicas com a peculiaridade do ponto de vista infantil para o delineamento de modos alternativos de conhecer o mundo. Destaca-se a proximidade entre tais modos de conhecimento e a cunhagem peculiar de conceitos empregados por antropólogos e filósofos contemporâneos que se desviam da epistemologia hegemônica. Para ampliar o campo de debate, consideram-se, ainda, brevemente, os diários e memórias de Carolina Maria de Jesus, escritora descendente de africanos, semialfabetizada mas prolífica e potente. Nesse percurso, procura-se destacar a dimensão investigativo-crítica da forma narrativa.Palavras-chave: narrativa; modos de existência; perspectivas de conhecimento; linguagem verbal; marcas não verbais de enunciação.Abstract: We aim to study Guimarães Rosa’s narratives as a construction of a poetic language that opens new perspectives to thinking, placing itself away from the parameters of Western rationality. As an analytical strategy, a parallel is traced between the boy Miguilim Rosian story and the Africanist Amadou Hampâté Bâ autobiographical account, with attention to the chapters that refer to his childhood. In both narratives, it is possible to observe the combination of archaic oral cultures surviving aspects with the infantile point of view peculiarity o for the designing of alternative ways of knowing the world. We emphasize the proximity between such ways of knowledge and the peculiar concepts coinage employed by contemporary anthropologists and philosophers that deviate from hegemonic epistemology. To broaden the field of debate, we also consider briefly the diaries and memoirs of Carolina Maria de Jesus, an African-descendant writer, semi-literate but prolific and powerful. Consequently, the research-critical dimension of the narrative form is highlighted.Keywords: narrative; modes of existence; knowledge perspectives; verbal language; non-verbal marks of enunciation.