bluuebunny/crossref_metadata_2025 huggingface dataset:
Biochemical and histological changes in two nonalcoholic fatty liver disease models of different severity
Authors: Brus T. V. , Vasiliev A. G.
Published: July 2024

Background. One of the priority areas of modern medicine, which unites the interests of various specialists (therapists, cardiologists, gastroenterologists, endocrinologists), is the study of the pathogenesis and clinical manifestations of nonalcoholic fatty liver disease (NAFLD), which is widespread and of unconditional social significance. The search for adequate experimental models of NAFLD that reflect the severity of liver damage is of paramount importance for studying its etiology and pathogenesis.The aim of the study. To compare biochemical and histological changes in experimental models of NAFLD of varying severity.Materials and methods. Two NAFLD model versions were used: a light one – nonalcoholic steatosis (NAS) and a severe variant – non-alcoholic steatohepatitis (NASH). The following biochemical parameters were measured: enzyme activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (AP), plasma glucose concentration, total protein (TP), total bilirubin (TBil) and its conjugate fraction (CB), plasma concentrations of homocysteine (HC), total cholesterol (TC), triacylglycerides (TG), catalase (Cat), superoxide dismutase (SOD) and malondialdehyde (MDA).Results. When used in a model of steatohepatitis, liver function was impaired to a significantly greater extent than in the model of steatosis; this difference was manifested in a statistically significant increase in ALT, AST, AP, TC, Tbil, MDA (p < 0.001) and a decrease in Cat, SOD (p < 0.05). This is confirmed by the development of more pronounced symptoms of disorders of pigment and lipid metabolism, cytolytic and cholestatic syndromes, significant activation of lipid peroxidation and depression of the antioxidant system when modeling non-alcoholic steatohepatitis. Various degrees of severity of morphological changes in the experimental groups were revealed.Conclusion. The study showed the priority of determining biochemical markers, including the levels of ALT, AST, OBIL, TG, MDA and SOD to optimize laboratory methods for diagnosing the severity of liver dystrophy.The practical originality of the results lies in the optimization of the methodology for laboratory diagnosis of the severity of the pathological process in NAFLD.
The effect of aluminum- and silicon-containing enterosorbent on the thymic cellular composition in mice kept under two-week all-night lighting
Authors: Miroshnichenko S. M. , Michurina S. V. , Ishchenko I. Yu. , Rachkovskaya L. N. , Serykh A. E. , Rachkovsky E. E. , Letyagin A. Yu.
Published: July 2024

Background. Continuous lighting contributes to the development of desynchronosis, which is stressful for the body. As a result, the normal functioning of the immune system is disrupted, which in turn can shift the physiological balance towards pathology and endotoxemia. It is relevant to develop innovative drugs based on a sorbent matrix, which can be modified with biologically active molecules that extendedly leave the sorbent surface. At the same time, the sorbent retains the properties of a detoxifier, fixing toxic agents on the surface and removing them from the body, which helps restore the internal environment and normalizes the overall reactivity of the body in extreme conditions.The aim. To study the effect of aluminum- and silicon-containing enterosorbent (based on aluminum oxide and polydimethylsiloxane) on the cellular composition of the thymus and the distribution of thymocytes in the organ according to the cell cycling state in C57Bl/6 mice kept under the all-night lighting.Materials and methods. Animals received sorbent (0.665 g per 1 kg of body weight in 200 μl of distilled water) through an intragastric tube once a day for 14 days against the background of continuous lighting. Intact mice and placebo animals composed control group. We used flow cytometry to assess the percentage of CD3hi and CD3low lymphocytes of the thymus, the CD3low/CD3hi ratio, viability and distribution of cells across according to the cell cycling state.Results. Continuous lighting inhibited the differentiation and maturation of young CD3low lymphocytes into mature forms of CD3hi, reduced the proliferation of thymic epithelial cells, and activated apoptosis of lymphocytes and epithelial cells in the organ. The introduction of the sorbent restored the content and viability of young CD3low lymphocytes and contributed to the preservation of the viability and proliferation of thymic epithelial cells.Conclusion. Using an enterosorbent based on aluminum oxide and polydimethylsiloxane under conditions of continuous lighting helps maintain the functional activity of the thymus, preventing its involution, and is advisable against the background of circadian disruption.
Effect of the organoselenium compound 974zh on the TLR2 and TLR4 gene expression in blood and spleen cells of experimental animals when co-administered with Yersinia pestis EV
Authors: Pyatidesyatnikova A. B. , Dubrovina V. I. , Yurieva O. V. , Korytov K. M. , Ivanova T. I. , Potapov V. A. , Musalov M. V. , Balakhonov S. V.
Published: July 2024

One of the important directions for increasing the immunogenic properties of vaccine strains against highly dangerous infections is the search for adjuvants that not only stimulate the immunological effectiveness of vaccination, but can also provide a metabolic correction of the vaccination process. Organoselenium compounds have immunotropic properties and an antioxidant effect, and therefore, the study of the effect of the organoselenium compound 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the activity of the TLR2 and TLR4 gene expression by macroorganism cells of experimental animals immunized with Yersinia pestis EV NIIEG vaccine strain, is a current area of research.The aim of the work. To assess the TLR2 and TLR4 gene expression by cells of the immune phagocyte system of experimental animals immunized with the Y. pestis EV vaccine strain against the background of immunomodulation with the organoselenium compound 974zh.Materials and methods. The study was carried out on 125 certified outbred white mice. Biological material (blood, spleen) was disinfected, and the spleen was homogenized. RNA isolation and reverse transcription were performed using commercial reagent kits. The expression level of the TLR2 and TLR4 genes was determined using real-time polymerase chain reaction with specific primers.Results. When assessing innate immunity using the example of blood and spleen cells of animal models, features of the TLR2 and TLR4 gene expression were revealed in response to the introduction of the Y. pestis EV vaccine strain against the background of immunomodulation with the 974zh. It was found that 974zh induces a statistically significant increase in TLR2 gene expression when co-administered with Y. pestis EV at a dose of both 104 CFU and 103 CFU.Conclusion. Y. pestis EV against the background of immunomodulation with 974zh, stimulates the expression of the TLR2 and TLR4 genes, which may indicate an increase in the immunogenic properties of the Y. pestis EV vaccine strain under the influence of this preparation.
Parenteral chronic viral hepatitis in the Arctic zone of the Republic of Sakha (Yakutia) as the most important medical and social problem
Authors: Sleptsov S. S. , Sleptsova S. S.
Published: July 2024

Background. The severe course of parenteral viral hepatitis and their further chronicity are associated with the presence of immunodeficiency disorders, frequency of which increases significantly in harsh climate. The article discusses the spread of parenteral viral hepatitis in the Arctic zone of the Republic of Sakha (Yakutia) and the issues of organizing medical care for patients with chronic viral hepatitis at the regional level.The aim of the study. To analyze the incidence rates of parenteral viral hepatitis in the Arctic regions of Yakutia in order to improve the health care system using the example of remote areas of hard access.Methods. The work uses materials from official statistics of the territorial department of Rospotrebnadzor for the Republic of Sakha (Yakutia) for 2000–2022 and information from the “Chronic viral hepatitis in the Republic of Sakha (Yakutia)” register. Results. In the Arctic regions of Yakutia, problems are observed in chronic forms of viral hepatitis B, C and D, as well as in their outcomes, such as cirrhosis and liver cancer, leading to early disability and mortality. In the general structure, hepatitis B infection prevails, which indicates the presence of family foci of infection. All this requires a complex of not only therapeutic, but also advanced anti-epidemiological measures.Conclusion. The difficult epidemiological situation regarding parenteral viral hepatitis, caused by extreme natural and climatic conditions, genetic characteristics of the indigenous population and the lack of medical institutions specializing in the treatment of chronic viral hepatitis, dictates the need to strengthen systematic on-site monitoring studies and telemedicine consultations in the Arctic zone of Yakutia. Thanks to this, residents of hard-to-reach areas of the Arctic zone of the Republic of Sakha (Yakutia) will be able to receive targeted subsidized care for the treatment of chronic hepatitis without traveling to Yakutsk.
Risk factors for diminished ovarian reserve in women: Current state of the problem
Authors: Zotov S. V. , Likhacheva V. V. , Motyreva P. Yu. , Azarova O. V. , Ayzikovich B. I.
Published: July 2024

Ovarian reserve is the basis of female fertility. The main markers of ovarian reserve are the level of anti-Mullerian hormone and the number of antral follicles. In addition to the natural age-related loss of follicles, many women experience a premature diminished ovarian reserve associated with a number of factors. This can be caused by both various diseases and environmental factors, lifestyle, and social aspects.The aim of this review was to examine the influence of external factors on the ovarian reserve and women fertility. A systematic analysis of data from modern scientific literature, domestic and foreign sources was carried out. The search involved such resources as PubMed, MEDLINE, Science Direct, eLibrary, Scopus, Cyberleninka. A detailed analysis of the influence of environmental pollution, lifestyle (sleep, nutrition, physical activity), previous surgeries, bad habits, obesity, psychological and social factors on the ovarian reserve and reproductive function of women was carried out. Significantly diminished ovarian reserve was noted with low sleep quality, excessive physical activity, and an unbalanced diet poor with animal proteins. Regular consumption of alcohol, smoking and exposure to certain chemical environmental pollutants cause premature follicle apoptosis and the onset of menopause. Circadian dysrhythmia, chronic stress and obesity can lead to the ovarian menstrual cycle disorders and the development of infertility in women. Previous parovarium surgeries are a significant risk factor for diminished ovarian reserve. Further population-based studies are needed to determine the precise mechanisms of influence of various factors on female fertility.
E. S. Skoblikova, a linguist and a teacher (to mark the centenary of the scientist’s birth)
Authors: Ilyukhina N. A.
Published: July 2024

The article characterises the scientific legacy of Professor E. S. Skoblikova (1 June 1924 – 12 August 2016), a prominent Russian linguist, a specialist in modern Russian syntax, Russian dialectology, Russian orthography. The scientist authored monographs, university textbooks and manuals, series of articles on basic linguistic disciplines. She also compiled and edited the posthumous editions of university textbooks and fundamental scientific works of Professor A. N. Gvozdev, a corresponding member of the Academy of Pedagogical Sciences of the RSFSR. The relevance of E. S. Skoblikova’s scientific works is determined by the distinctive feature of the theoretical and methodological orientation of her works, namely the adherence to the traditional approaches in resolving controversial issues and the interconnection of scientific and pedagogical thought. This principle remains significant in the conditions of the equally important principle of scientific pluralism.
Textbook review: N. A. Nikolina, L. V. Ratsiburskaya. Modern Russian word formation: Functional-dynamic aspect: study guide. Moscow: Flinta, 2023. 176 p.
Authors: Bets Yu. V. , Ilyasova S. V.
Published: July 2024

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Specific features of collecting nicknames in the process of academic work and research activity
Authors: Bobrova M. V.
Published: July 2024

The article considers the applied aspects of onomastics and is related to the major issue of collecting modern nicknames which students (schoolchildren and students) may encounter as part of their academic work and research activity. Since it is fundamentally impossible to record all unofficial anthroponyms, the study focuses on the issue of the effectiveness of various material collection methods, namely questionnaires and survey forms as the main ones, conversations, observations, and sampling data from various sources as secondary techniques. In particular, the article specifies the structure of the questionnaires used by the author in tabular form. Moreover, the presented detailed survey forms for obtaining individual and collective nicknames developed by the author are based on the recommendations given in previous studies as well as the author’s own experience. The proposed questionnaires and survey forms can be used in academic work and research activity within the framework of scientific projects. The paper also identifies the advantages and disadvantages of each method. The article discusses the specific features of field work in rural settlements and under stationary data collection conditions. The objective of certifying the obtained materials is raised. It is concluded that involving students in onomastic data collection as part of their academic work and research activity can help in solving relevant scientific issues.
A. N. Radishchev as an "archaist and innovator": linguopoetic and linguostylistic features of the great book (to the 275th anniversary of the birth)
Authors: Romanov D. A.
Published: July 2024

The article considers the most important linguopoetic and linguostylistic characteristics of A. N. Radishchev’s "A Journey from St. Petersburg to Moscow". The research also focuses on the precedent phenomena in the text of the book, its connections with the European artistic tradition, and influence on the Russian literary language evolution, as well as on particular genres of Russian literature. The text is examined against the background of the dominant literary canons of sentimentalism at the time of its writing; the author creatively mastered some of these canons. Radishchev developed his individual style which synthesised three main linguistic elements: emotional-sensual, civic rhetorical, and common colloquial. Each of them is characterised by a certain set of linguistic means that are compositionally anchored in the text. The figurative devices of classicistic poetics, tropeic expressiveness, refined linguistic expressions borrowed from Western literature, and vocabulary new for the late 18th century form the compositional parts characteristic of the journey as a distinct literary genre. A. N. Radishchev uses Slavicisms, archaic morphological forms and obsolete syntactic constructions, neologisms based on Church Slavonic patterns to create high civic pathos and embody freedom-loving ideas. Low colloquial speech, folk phraseology, folklore inserts, aphorisms, and mixtures of styles shape the author’s narrative fragments and reflections related to specific life situations.
Value-based Russian language teaching as a priority of the modern era (to mark the anniversary of the Axiological linguistic methodology school of thought)
Authors: Deikina A. D. , Kulayeva G. M. , Levushkina O. N. , Yanchenko V. D.
Published: July 2024

The article aims to comprehend the fundamental role of value-based Russian language teaching in modern education. The key points of the speeches delivered by Russian President Vladimir Putin, His Holiness Patriarch Kirill, and Minister of Education of the Russian Federation S. S. Kravtsov are related to the preservation and strengthening of traditional spiritual and moral values. Therefore, the thirty-year activity of the scientific school Axiological linguistic methodology: the worldview and value aspects in school and university teaching of the Russian language, the leader of which is Doctor of Pedagogical Sciences, Professor of the Department of Methods of Teaching the Russian Language at the Institute of Philology of MPSU, is A. D. Deikina, winner of the Russian state award - the A. S. Pushkin medal, the K. D. Ushinsky medal, is becoming more relevant than ever. We used analysis of scientific research in the field of axiological linguistic methodology and scientific generalisation to characterise the activities of the scientific school whose origins relate to M. T. Baranov’s concept of schoolchildren’s linguistic worldview formation. Moreover, we outlined the key positions of axiological linguistic methodology substantiated in the concept of A. D. Deikina and thirteen postdoctoral studies of her students as scientific areas developing the idea of value-based Russian language teaching at school and university. The postdoctoral research conducted within the framework of the scientific school of axiological linguistic methodology with A. D. Deikina as the scientific advisor developed the leading linguistic methodological approaches to Russian language teaching. Drawing on the Russian canonical methodologists’ ideas, the members of the Moscow Methodological Scientific School create and predict promising ways of developing higher and school education in the Russian Federation, expand the research space in different regions of this country, increase the scientific status of methodological science, and contribute to the success of interpersonal and intercultural communication in Russian. The works of those who represent the axiological linguistic methodological scientific school, as well as other like-minded researchers have a beneficial effect on the creation of a holistic value picture of the world using the Russian language in modern education.
Specific features of Russian coordinating conjunctions from the activity approach perspective
Authors: Biryukova E. V. , Borisova E. G. , Kalyatin I. S.
Published: July 2024

The article examines the specific features of Russian coordinating conjunctions, first and foremost primary i (English and), a (English while, and), no (English but), da (English but, and). The prepositions are examined from the standpoint of the activity approach to the description of linguistic units, i. e., considering the actions of the speaker using these conjunctions, as well as the listener who, thanks to them, receives the information necessary to understand a coherent text. Particular attention is given to the primary conjunctions due to their key role in text organisation. Numerous compound conjunctions and prepositions only develop some of the subtleties of connection against the background of text organisation. Data from several foreign languages are also used to expand the picture since the system of simple coordinating conjunctions in Russian is unique and finds no exact correspondence in other languages. The conjunctions are semantically described taking into account their general meanings and functions. A new interpretation is proposed for the conjunction da. The functions of the conjunctions are associated with the communicators’ activity. During interaction, the speaker partially prompts what kind of information the listener will get. In particular, the conjunction i and its analogues in many other languages indicate that something similar to the previous message will be communicated. The conjunction no shows a violation of the addressee’s expectation, and this function is also very common in the world’s languages. In a few languages there are more subtle indications of the subsequent message content. For example, one can use the conjunction a in Russian to warn that something new, but not necessarily contradictory to the previous information, will be communicated. Finally, it remains possible to signal the addition of information suggesting its exhaustiveness, which is expressed with the conjunction da in a few of its meanings. Marking precisely such semantic relations enables one to draw a conclusion about possible connections between sentences in the text and the presupposition in it regarding the course of the narration.
Precedent texts as linguistic mechanisms for creating an attractive newspaper headline in the Internet media discourse
Authors: Radbil T. B. , Ratsiburskaya L. V.
Published: July 2024

The article examines newspaper headlines produced using precedent phenomena, and thereby they act as effective linguistic mechanisms for creating media text attractiveness. The research material is comprised of newspaper headlines obtained from the online versions of "Rossiiskaya Gazeta" texts for 2023 and 2024. We used cognitive discourse analysis in conjunction with a comprehensive methodology for examining active processes in language. We assume that headlines convey certain information about the text content and can perform text-forming and evaluative functions. The study analysed the sources of headlines based on precedent phenomena, types of precedent text transformation, functions of using precedent texts to create newspaper headlines in the modern Internet media language. The research shows that precedent text sources in the headings are well-known works of literature and art, phraseological units and proverbs, the so-called catchphrases, other set expressions and clich  es. Structural-semantic, semantic proper, and pragma-semantic models for transforming original precedent texts were identified. The paper also characterises such functions of using precedent text in headlines as the informative, text-forming, persuasive, expressive, evaluative, and attraction functions. We conclude that the considerable persuasive, attractive, and evaluative potential of precedent phenomena in headlines is most often realised in transformed precedent texts. This is associated with the foregrounding of cultural information known to readers due to its link to a specific precedent phenomenon. New information relevant to a particular author in a particular text is superimposed on the familiar cultural information in a figurative, playful form.
Russian elements in the ergonymy of intra-urban objects in Moscow
Authors: Matyushina N. V.
Published: July 2024

The article presents a fragment of a study examining the ergonymy of intra-urban objects in Moscow. The research focuses on ergonyms created on the basis of the Russian language. The study aims to find out what names of commercial enterprises are more attractive to city residents, which of them provoke positive, neutral, or negative emotions. The material for the study included the names of commercial enterprises in Moscow formed with the techniques of retrohybridisation, quasi-naming, anti-orthography, superimposition of words, and allusion. During the study, 2700 names of commercial enterprises located on the signs, bracket panels, and in the shop windows of establishments in the main streets of Moscow were collected. The selected ergonyms were classified according to their formation methods. A survey involving 90 respondents of different ages and educational backgrounds was conducted as well. The data obtained during the survey were processed using statistical analysis. Based on the experimental results, the study revealed that ergonyms with letters from the pre-revolutionary script had positive evaluations more often. Also, they were the most memorable. The largest number of negative evaluations was given to the names with a deliberate distortion of the Russian orthographic norm. Drawing on the data obtained, the paper formulates recommendations to those who create commercial enterprise names aimed at different age groups of consumers. The results of the work can be used in linguodidactics, for example, in the process of teaching Russian as a foreign language.
Isolation and Identification of the Ammonium and Nitrite Oxidizing Bacterial Strains for Nitrogen Treatment in Shrimp Pond in Quang Ninh Province, Vietnam
Authors: Nguyen Thi Tham  , Pham Quy Giang  , Dinh Quynh Oanh  , Diep Thi Thu Thuy  , Hoang Thi Bich Hong  , Pham Thi Huong
Published: July 2024

The objective of this study was to isolate and identify the nitrifying bacteria from wastewater in the aquaculture system at Quang Ninh province and initially evaluate their ability to treat nitrogen in water and determine the strain of bacteria and identify the strain of bacteria. Nitrifying bacteria were isolated by serial dilution and agar plates and then purified by agar slant until axenic colonies were obtained. The study has successfully isolated 3 bacterial strains capable of ammonium oxidation (AOB-1, AOB-2, AOB-3) and 3 bacterial strains with nitrite oxidation ability (NOB-1, NOB-2, NOB-3) from shrimp farming wastewater in Quang Ninh province, Vietnam. These strains demonstrate potential for ammonium and nitrite oxidation, making them applicable for nitrogen treatment in sewage. Strains with nitrite oxidation ability showed a potential high capability for nitrogen removal from water. The decoding of the 16S rRNA gene sequences, compared using Blastn (NCBI) indicated similarities with Bacillus subtilis (AOB-1), Pantoea agglomerans strain JCM1236 16S RNA (AOB-2), Enterobacter hormaechei strain ES1 16S RNA (AOB-3), Arthrobacter nicotianae (NOB-1), Acinetobacter lactucae strain JVAP01 16S RNA (NOB-2) and Enterobacter asburiae (NOB-3). Therefore, the bacteria that contained 6 strains can be considered to apply for wastewater treatment in shrimp farming.
A GIS-based suitability analysis for siting a waste-to-energy power plant in Kaduna, Nigeria
Authors: Vivian Aaron Ibrahim  , Elizabeth Rizga Jackson  , Epsar Philip Kopteer  , James Adah John  , Kamila Abba Tukur  , Augustine Abah Odeh  , Udya Aniya  , Jibatswen Agbutsokwa Hosea  , Nazifa Musa Bauka  , Binta Ahmad  , Timothy Samuel Tiworoiyang  , Sunday Adah Ikwue
Published: July 2024

The success of any waste management system requires accurate and up-to-date data on quantity, and composition of waste. Waste generation data from households are needed to address issues relating to municipal solid wastes such as management methods, performance improvement, policy, regional and local planning, administration, cost accounting, design and operation of landfill facilities, and environmental quality. This study carried out a suitability analysis for siting a waste-to-energy power plant in Kaduna using GIS and remote sensing techniques with the specific objectives of identifying existing waste dumpsite in the study area, identifying other factors needed for waste-to-energy plant in the area, and identifying the most suitability site of waste-to-energy in Kaduna. The slop map of the study area was created using the Shuttle Radar Topographic Mission (SRTM). In the ArcGIS environment, Euclidean distance analysis was performed on institutions, rivers, dumpsites, roads, markets, transmission lines, and electricity substations. The waste-to-energy power plant suitability map was created using a multi-criteria technique by overlaying the datasets. The waste-to-energy-power-plant suitability map was made by combining the criteria. Dogon Dawa, Sabon Birinin Jaji, Ganga, Buruku, chikun, Dokwa, ikara, and Kuban are the best sites. The results of the site suitability assessment further revealed that the Makafia local government, located in the city's northern outskirts, was the most suitable area for locating the waste-to-energy power plant, covering 73686 hectares, or 26% of the total area. In addition, the map lays the groundwork for decision-makers to locate a waste-to-energy generating plant. This study shows how decision-making about solid waste management may benefit from the use of geospatial technology. Additionally, it is advised that before approving the placement of a waste-to-energy power plant, decision-makers in the study region refer to it as a reference.
Evaluating financial risk management in corporation financial security systems
Authors: Tanvir Rahman Akash  , Jafrin Reza  , MD Ashraful Alam
Published: July 2024

Systemic risks are relevant to most segments of financial and economic activity, which creates the threat of financial instability of enterprises. Financial security, in this case, implies the state of financial soundness; it is expressed through various parameters including the level of solvency, financial stability, business activity, and efficiency of management. These questions are specific to each indicator, and this paper aims to understand their relations and how changes in them can result in risks. It elaborates the risk analysis and assessment procedure that uses a set of common financial analysis tools and determines key financial coefficients. Liquidity ratios, solvency ratios, profitability ratios, and the risk exposure metrics are the key areas that the research is based on. Correlating the financial indicators from a rich dataset from Yahoo’s Stock market data, regression analysis is used to determine these relationships between these indicators and risk management factors. A positive relationship between liquidity ratios and profitability is detected points to the fact that, firms with high liquidity levels are more capable of attaining good financial health and returns. It establishes the need for the development of a credible risk management structure that would lower threats to fiscal and economic activities. In light of this, the research shows that the liquidity and solvency management lowers financial risk and improves return for companies. The regression analysis was conducted to ascertain the degree of predictability of each independent variable to the dependent variable and the findings revealed that approximately 94 percent of each independent variable is predictable of the dependent variable that able to establish as much as 5% of the total variability in profitability, with the PE ratios being an indication of this aspect, was attributed to stock prices, as a result, the firm must be keen on its financials. This paper explores the employability of the proposed methods and models to assess the risks with high accuracy and supports optimum decision making in regard with the needed security of the enterprises. By adopting these methodologies, the businesses can observe and estimate risks which exist in the future which would help them to avoid certain issues or dangers and also pave the way for the improvements of the financial stability of the businesses. On this note, the study establishes the fact that incorporating the notion of total risk management into the framework of analyzing business and making financial decisions is inevitable in maintaining corporate financial stability and realizing perpetual economic solidity. This research enriches the literature on financial risk management, as it outlines viable strategies for the protection of enterprise financial sustainability.
Philosophical issues of quantum mechanics
Authors: Spiros Koutandos
Published: July 2024

In this paper we discuss some of the philosophy of quantum mechanics regarding a hidden fifth dimension and the symbols used to describe the metaphysical issues of this.
The Influence of Family Experience and Environment on Alcohol Use in Patients with Mental Disorders
Authors: Kucher E. O. , Petrova N. N. , Pehkonen S.E. D. , Azarova L. A. , Dutov V. B. , Varaksa M. V.
Published: July 2024

Background: environmental influences on alcohol use in patients with mental disorders have received little research, although they may be another determinant of alcohol use beyond illness. The aim was to study the influence of family traditions and social environment on alcohol consumption by patients with mental disorders. Patients: 106 patients with various mental disorders who received treatment in inpatient and outpatient settings. Methods: patient information was received from the medical record and interviews using questionnaire “Alcohol use: experience, pattern, treatment” and scales: Alcohol Use Disorders Identification Test (AUDIT), Udvalg for Kliniske Undersogelser Scale (UKU), Drug Attitude Inventory-10 (DAI-10). Results: the proportion of patients with high risk for alcohol use problems was 21% of all patients. Patients with a high level of risk differed in the style of drinking alcohol in the parental family: their parents drank alcohol more often. These patients also had their first experience of drinking alcohol in their parental family. There were more people who drank alcohol in large quantities in the past environment of such patients. Although high-risk patients had changed their current environment, they were still more likely to make situational alcohol choices, use it more often to cope with difficulties, and appeared to use previously established drinking styles. All high- risk patients began drinking alcohol before the onset of the disease. Conclusions: patients with a high risk of problems with alcohol use are more likely to have learned their drinking style from their parents, and they are more likely to drink alcohol under the influence of the situation. However, one third of patients were able to reduce their alcohol consumption during illness.
Age-Related Development During Predictors and Clinical Neurodiagnostic Criteria of Cognitive Impairment in the General Medical Network
Authors: Trofimova E. V. , Reverchuk I. V. , Tynterova A. M. , Goncharov A. G. , Dzhigkaev A. H.
Published: July 2024

Background: prevalence, severity and heterogeneity of cognitive impairment in elderlies along with limited therapy options determine the relevance of the problem of timely diagnostics of cognitive disfunction. The purpose of this study is to identify a combination of the most informative patterns that allow a differentiated approach to the diagnosis of age-related cognitive impairment. Patients and methods: 213 patients were examined (99 patients 50–65 years old, 114 patients over 65 years of age) of “Federal Centre for High Medical Technologies” of Russian Ministry of Health (Kaliningrad). All patients complained for impaired mental performance, memory and attention. A neuropsychologic testing was conducted using next scales: Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS), Multidimensional Fatigue Inventory (MFI-20) and additional cognitive impairment tests. For statistical analysis, machine learning algorithms, Python programming language, and Pandas and SciPy libraries were used. Results: for patients in the 50–65 age category, high relevance was found for executive dysfunction, decreased attention span, fatigue, anxiety, and endocrine system disorders. For patients over 65 years of age, significant features were semantic aphasia, perceptual and memory impairment, hyperlipidemia, history of ischemic stroke, and obesity. A significant negative correlation for the age index was found with the parameters of depression and anxiety; a positive correlation was found with the index of physical asthenia, disorders of perception, memory and semantic processing of information. Conclusion: the results demonstrate prevalence of cognitive dysfunctions in elderly patients. The tests assessing visual perception and semantic information processing can be of interest in early degenerative cognitive impairments diagnosis in elderly age. Discriminant analysis of a wide range of age-related variables will allow to make more effective aging trajectories prediction without any time-consuming diagnostic methods.
Cognitive Profile of Patients with Borderline Personality Disorder
Authors: Petrova N. N. , Charnaia D. I. , Chumakov E. M. , Azarova L. A.
Published: July 2024

Background: the relevance of this study stems from the difficulties in diagnosing borderline personality disorder (BPD) and the importance of studying neurocognitive functioning for expanding the understanding of mental disorders. The available data on the cognitive profile of patients with BPD vary markedly. We could not find any studies in this area in a domestic sample. The aim of the study was to investigate the cognitive profile of patients with BPD. Patients and methods: 50 patients (72% women; n = 36; 28% men; n = 14) aged 22.4 ± 4.3 years with ICD-10 diagnosis F60.31 “Emotionally unstable personality disorder, borderline type” were examined. The research methods included clinical and scale assessment: Hospital Anxiety and Depression Scale, Hamilton Depression Scale, Hamilton Anxiety Scale, SCL-90 symptom questionnaire, Borderline Personality Disorder Questionnaire, Brief Assessment of Cognition in Schizophrenia. Results: the obtained data indicate the presence of cognitive impairment in patients with BPD. The structure of neurocognitive deficit includes impairments of working and verbal memory and attention. The severity of BPD is associated with lower cognitive functioning. No correlation between affective symptomatology in BPD and the degree of cognitive impairment was found.
The Foundations and Practice of Neuropsychological Diagnostics in the Context of Forensic Psychiatric Examination
Authors: Pilechev D. A. , Mikadze Yu. V. , Vandysh-Bubko V. V. , Gilenko M. V.
Published: July 2024

Background: cognitive impairments are comorbid for most mental disorders and can be important in assessing the ability of a subject to understand and control their actions in legally significant situations. The aim of review: аnalysis of neurobiological correlates and cognitive impairments in individuals suffering from mental disorders — organic personality disorder, schizophrenia, borderline personality disorder, in the context of forensic psychiatric examination. Material and methods: using keywords: “cognitive impairments in schizophrenia”, “cognitive impairments in organic personality disorders”, “cognitive impairments in personality disorders”, “MRI in schizophrenia”, “MRI in organic personality disorder”, “MRI in personality disorder”, “forensic neuropsychology”, “schizophrenia and criminal actions”, “organic personality disorders and criminal actions”, “personality disorders and criminal actions” the search and analysis of scientific publications was carried out in PubMed, Scopus, and RSCI databases over the past 5 years. Conclusion: schizophrenia shows deviations in the functioning of frontal and temporal lobes characterized by cognitive impairments: executive functions, attention, auditory-verbal memory, psychomotor slowness, inconsistent behavior, and deficits in volitional efforts. Borderline personality disorder is associated with reduced volume of the anterior cingulate gyrus, hippocampus, amygdala, and prefrontal cortex, dysfunctional interaction between limbic and prefrontal areas resulting in difficulties in emotion identification and impulsivity. Individuals with a history of traumatic brain injury (TBI) and secondary personality disorders exhibit diffuse gray matter damage affecting frontal, temporal, and parietal regions, emphasizing dysfunction of limbic-reticular complex structures with cognitive impairments including decreased thinking speed, attention stability, executive functions, auditory-verbal memory, visual-spatial memory, visual-motor coordination, and decreased impulse control. Individuals with mental disorders who commit criminal acts often exhibit deficiencies in frontal lobes and associated disturbances in executive components of mental activity, particularly cognitive flexibility and planning. Neuropsychological methods for studying cognitive functions can be used to obtain additional information in forensic psychiatric examinations.
Analisis Pengaruh Gaya Kepemimpinan Situasional, Lingkungan Kerja dan Beban Kerja Terhadap Kepuasan Kerja Keryawan (PT Serinding Sumber Makmur)
Authors: Hendro
Published: July 2024

Abstrak
Sumber daya manusia merupakan aset terpenting dalam suatu organisasi bisnis atau perusahaan karena mereka menjalankan kebijakan dan aktivitas operasional perusahaan. Kepuasan kerja adalah tanggapan karyawan terhadap pekerjaan mereka, bisa berupa respons positif atau negatif. Untuk mencapai kepuasan kerja, ada tiga faktor utama yang perlu diperhatikan, yaitu gaya kepemimpinan situasional, lingkungan kerja, dan beban kerja. Penelitian ini bertujuan untuk memahami pengaruh gaya kepemimpinan situasional, lingkungan kerja, dan beban kerja terhadap kepuasan kerja karyawan di PT. Serinding Sumber Makmur. Metode yang digunakan adalah deskriptif kuantitatif dengan populasi  karyawan PT. Serinding Sumber Makmur. Sampel diambil menggunakan rumus sloving, data dianalisis menggunakan aplikasi IBM SPSS. Hasil penelitian menunjukkan bahwa gaya kepemimpinan situasional tidak memiliki pengaruh signifikan terhadap kepuasan kerja karyawan. Implikasinya, strategi pengembangan kepemimpinan situasional mungkin perlu diperkuat atau dikaji lebih lanjut untuk mempengaruhi kepuasan kerja secara lebih efektif di perusahaan ini. Di sisi lain, lingkungan kerja terbukti berpengaruh signifikan terhadap kepuasan kerja, menunjukkan pentingnya mempertahankan atau meningkatkan kondisi lingkungan kerja yang mendukung karyawan agar dapat meningkatkan kepuasan mereka. Sementara itu, beban kerja tidak berpengaruh terhadap kepuasan kerja, yang mengindikasikan bahwa fokus pada pengelolaan beban kerja mungkin tidak menjadi prioritas utama dalam upaya meningkatkan kepuasan kerja di perusahaan ini. Implikasi keseluruhan dari penelitian ini adalah pentingnya manajemen perusahaan untuk mempertimbangkan faktor-faktor tersebut dalam upaya meningkatkan kepuasan kerja karyawan, dengan fokus khusus pada pengembangan strategi kepemimpinan situasional dan perbaikan kondisi lingkungan kerja.
Keywords: Gaya kepemimpinan situasional; lingkungan kerja dan beban kerja terhadap kepuasan kerja
Different Characteristics of Psychological and Sleep Symptoms Across Social Media Addiction and Internet Gaming Disorder in Chinese Adolescents- A Network Analysis
Authors: Zhang Wanling , Jiang Liwen , Yu Minglan , Ma Rong , Wang Tingting , Liang Xuemei , He Rongfang , Xu Chun , Hu Shasha , Tan Youguo , Liu Kezhi , Xiang Bo
Published: July 2024

Objective Previous research has explored a variety of mental disorders associated with Internet Gaming Disoder (IGD) and Social Media Addiction (SMA). To date, few studies focused on the network characteristics and investigated mood and sleep symptoms across SMA and IGD of adolescence at a group-specific level. This study aims to identify different characteristics of IGD and SMA and further determine the group-specific psychopathology process among adolescents.Methods We conducted a cross-sectional study to recruit a cohort of 7,246 adolescents who were scored passing the cutoff point of Internet Gaming Disorder Scale-Short Form and Bergen Social Media Addiction Scale, as grouped in IGD and SMA, or otherwise into the control group. Patient Health Questionnaire-9, Generalized Anxiety Disorder 7-item, and Pittsburgh Sleep Quality Index were assessed for the current study, and all assessed items were investigated using network analysis.Results Based on the analytical procedure, the participants were divided into three groups, the IGD group (n=789), SMA group (n=713) and control group (n=5,744). The edge weight bootstrapping analysis shows that different groups of networks reach certain accuracy, and the network structures of the three groups are statistically different (pcontrol-IGD=0.004, pcontrol-SMA<0.001, pIGD-SMA<0.001). The core symptom of SMA is “feeling down, depressed, or hopeless”, while IGD is “feeling tired or having little energy”.Conclusion Although IGD and SMA are both subtypes of internet addiction, the psychopathology processes of IGD and SMA are different. When dealing with IGD and SMA, different symptoms should be addressed.
Effectiveness of the Korean-Patient Placement Criteria for Alcohol Use Disorders: A Prospective Exploratory Study
Authors: Park Sang-Wook , Choi Hayeong , Na Eui Hyeon , Oh Hong Seok , Roh Sung Won , Lee Sang Kyu
Published: July 2024

Objective Various patient placement criteria (PPC) have been developed to address alcohol use disorder (AUD), which has a high relapse rate and imposes substantial socioeconomic costs. Although research has shown PPC to be an effective tool, evidence supporting the Korean-PPC (K-PPC) is insufficient. This paper investigated whether treatment matching with the K-PPC was effective, based on variables related to AUD.Methods In total, 524 participants were evaluated using the 6 dimensions of the K-PPC and levels of care (LoC) were recommended based on the results. Participants whose treatment matched with the recommended LoC were classified into the matched group, and those whose treatment did not match were classified into the mismatched group. Subsequently, treatment was planned according to the determined LoC, and a total of 3 follow-up evaluations were conducted at 1 month, 3 months, and 6 months.Results There was no significant difference in the follow-up rate between the K-PPC matched group and the mismatched group. Of the variables measured by the 6 dimensions of the K-PPC, alcohol-related variables, depression, insight, and biomedical outcomes showed the most significant results (especially alcohol-related variables) from the baseline evaluation to the 6-month follow-up. In addition, the average adherence to the treatment program in the 6-month period was found to be higher in the matched group than in the mismatched group.Conclusion The K-PPC could be effective for placing patients and providing treatment by matching patient characteristics. Enhancing treatment program retention can also have a positive effect on clinical outcomes.
Childhood Trauma and Non-Suicidal Self-Injury Among Chinese Adolescents: The Chain-Mediated Role of Alexithymia and Rumination
Authors: Wang Qiaoling
Published: July 2024

Objective To explore the associations between childhood trauma, alexithymia, rumination, and non-suicidal self-injury (NSSI) among adolescents and to provide theoretical and empirical evidence for effective prevention, identification, and intervention of NSSI in the future.Methods Questionnaires, including the Childhood Trauma Questionnaire, the twenty-item Toronto Alexithymia scale, the Ruminative Responses Scale, and the Adolescents Self-Harm Scale, were given to 1,270 Chinese teenagers. The mediating role was simulated utilizing Amos 24.0.Results The Pearson’s product-difference correlation analyses indicated the two-by-two significant correlations between childhood trauma, alexithymia, rumination, and NSSI. The structural equation modeling suggests that alexithymia and rumination partially mediate between childhood trauma and NSSI in teenagers, respectively. Additionally, it reveals that alexithymia and rumination chain mediate between childhood trauma and NSSI.Conclusion The study confirms the impact of childhood trauma on adolescents’ NSSI and also highlights the mediating role of alexithymia and rumination between the two. This study enriches the findings of NSSI and provides a theoretical basis for preventing and intervening in dysfunctional behaviors among adolescents.