bluuebunny/crossref_metadata_2025 huggingface dataset:
International and Indonesia's Teacher Performance : A Bibliometric Study Based on Vosviewer
Authors: Hidayat Rais , Patras Yuyun Elizabeth , Windiyani Tustiyana , Gunawan Yusuf
Published: March 2023

This study aims to analyze teacher performance from various perspectives, including a general description of teacher performance publications; trends; country; organization; source; authors, and the relationship between authors; and teacher performance research hotspots, both in international and Indonesian contexts. This study used the literature review method with data analysis using Vosviewer software. Scientific publication data comes from Scopus in 2003 – 2022 or the last 20 years as many as 393 documents. The findings of this study include the following: the publication of teacher performance in Scopus is still wide open; in the international context, the United States dominates the number of documents, citations, and sources; Indonesia ranks second after the United States even though it loses in the number of citations and links; new hotspots for developing research and publications on teacher performance include: decision support system, covid, attitude, values, authentic leadership, emotional intelligence, educative teacher performance, work discipline, job satisfaction, professional development activity, work motivation, compensation, educational reform, student achievement grade. This study is a source of decision-making for educational organization managers related to teacher performance research and development.
Long-term Clinical Course of Amniotic Membrane after Permanent Amniotic Membrane Transplantation
Authors: Kim Tae Hwan , Kim Seon Tae , Pak Min Gyoung , Park Woo Chan
Published: March 2023

Purpose: To investigate the long-term clinical outcomes of transplanted amniotic membrane in patients who underwent permanent amniotic membrane transplantation (P-AMT) on cornea.Methods: From April 2014 to March 2021, medical records and digital photographs of 68 patients (72 eyes) who underwent P-AMT were analyzed retrospectively. The duration of complete re-epithelization of cornea and wearing therapeutic contact lense (T-lens) after surgery were investigated, the size of preserved amniotic membrane (AM) excluding the melted portion was analyzed using the Image J program every year up to 6 years after surgery, and it was compared by dividing into a single-layer group and a double-layer group. In addition, when the AM melts, the cause, time, and related factors of melting were analyzed.Results: The average duration to complete re-epithelialization after surgery was 12.2 ± 11.0 days, and T-lens were worn on average up to 8.7 ± 8.5 months after surgery. In total group, the average ratio of preserved AM annually up to 6 years after surgery was 94.9%, 94.3%, 97.8%, 96.4%, 95.8%, 91.6% respectively, and there was no significant difference between the single-layer group and the double-layer group. AM melting appeared in 38.9% (28 eyes) of the total group, and melting was first observed on average 16.4 ± 17.2 months after surgery. The formation and rupture of bullae was the most common cause of melting at 71.4% (20 eyes), and there were no statistically significant related factors involved in the formation of bullae.Conclusions: In the case of P-AMT performed in various diseases of the cornea, the transplanted AM is partially melt but considered to be well preserved up to 6 years after surgery to form a stable ocular surface.
Factors Predicting Successful Selective Laser Trabeculoplasty to Prevent Glaucoma Progression to Surgery
Authors: Suh Hyun , Park Hae-Young Lopilly
Published: March 2023

Purpose: To investigate the factors predicting successful selective laser trabeculoplasty (SLT) to prevent glaucoma progression to surgery in patients whose intraocular pressure (IOP) is not controlled with medications.Methods: This retrospective chart review included 102 eyes of 92 glaucoma patients who underwent SLT between 2018 and 2020. Success was defined as the prevention of glaucoma surgery for at least 1 year with an IOP less than 21 mmHg or no progression of retinal nerve fiber layer thinning. Kaplan-Meier survival analysis and the Cox proportional hazard model were used for the analysis.Results: A low pretreatment IOP, good visual acuity, and a smaller visual field defect were significantly correlated with success. When the other eye underwent glaucoma surgery or its SLT treatment failed, the success rate of SLT was lower. As the pretreatment IOP increased by 1 mmHg, the SLT failure rate increased by 1,376 times and when the SLT for the other eye failed, it increased by 19,577 times. When the mean deviation of the visual field increased by 1 decibel (dB), the SLT failure rate decreased by 0.928 times (p < 0.05).Conclusions: SLT is more effective in early glaucoma patients with an IOP lower than 25 mmHg, smaller visual field defect, and good visual acuity to prevent glaucoma progression to surgery.
Outcomes of Bilateral Lateral Rectus Tucking in Patients with Divergence Insufficiency
Authors: Jo Min Soo , Park Soo Chul
Published: March 2023

Purpose: Divergence insufficiency is characterized by esotropia at far distance with symptomatic diplopia, minimal or no deviation at near distance, and full ocular duction and version. We analyzed the results of bilateral lateral rectus (BLR) tucking in patients with divergence insufficiency.Methods: Surgery was performed on patients with persistent distance diplopia with esotropia for at least 6 months after diplopia onset. The surgical results were evaluated after BLR tucking based on the maximum angle of deviation at distance among all the angles of deviation measured repeatedly, including the results of the prism adaptation test (PAT).Results: 24 patients were included. The average follow-up period was 14 months (1-48 months). The maximum deviations measured by alternate prism and cover test before surgery were 24.79 ± 8.15 prism diopter (PD) at far distance and 15.45 ± 9.30 PD at near distance. The PAT revealed that, the far distance deviation increased to 28.50 ± 7.77 PD and that at near distance to 25.88 ± 8.07 PD, but the difference between the two values fell to less than 3 PD on average. In 14 patients (58%), followed-up for up to 1 year, we noted no recurrence of diplopia or esotropia, or near distance overcorrection, with the exception of one patient who developed diplopia recurrence at far distance.Conclusions: BLR tucking guided by the maximum distance deviation of the 1 hour PAT affords stable results in patients with divergence insufficiency without overcorrection at near distance or undercorrection at far distance.
A Case of Sterile Peripheral Corneal Infiltrative Event after LASIK
Authors: Ha Seung Hee , Kim Hui kyung , Jo Yeon Ji , Lee Jong Soo
Published: March 2023

Purpose: To report a rare, sterile, peripheral, corneal infiltrative event after laser in situ keratomileusis (LASIK).Case summary: A 29-year-old male presented with left-eye conjunctival injection and peripheral corneal infiltration 3 days after LASIK. A whitish, oval, peripheral infiltration around the corneal flap was apparent from 6-to-10 o’clock in the limbus. Slit lamp examination revealed conjunctival injection and mild corneal edema but neither a corneal epithelial defect nor an inflammatory reaction of the anterior chamber. Intensive cycloplegic, steroid ointment, steroid drops, antibiotic drops, and artificial tear therapies were prescribed under the impression of a sterile, peripheral, corneal infiltrative event. After 1 month, the symptoms and corneal opacity resolved without any complications.Conclusions: A sterile, peripheral, corneal infiltrative event, namely, an oval infiltration of the periphery of the cornea without pain or epithelial damage can develop after LASIK but responds well to steroid eye drops.
Análise das internações pediátricas por condições sensiveis a atenção primária e seus desfechos
Authors: Santos José Yuri Silva , Farre Anny Giselly Milhome da Costa , Rocha Hertaline Menezes do Nascimento , Santana Marcos Antônio Gois , Santos Thaiane Santana , Nascimento Ester Batista do , Nascimento Nicoly Gabrielly Brito
Published: March 2023

Objetivo: Analisar as Internações por condições sensíveis a Atenção Primária em pediatria e seus desfechos. Métodos: Trata-se de um estudo do tipo coorte retrospectivo, com dados coletados dos registros das internações de crianças com idade entre 0 e 14 anos admitidas para internação pediátrica entre março de 2019 e fevereiro de 2020, que deram entrada pelo pronto-socorro, considerando as seguintes variáveis: idade, sexo, motivo de internação, local de internação, desfechos de saída e Internações por Condições Sensíveis a Atenção Primária, tomando como base a Lista Brasileira de Internações por Condições Sensíveis. Os dados foram registrados e analisados no software Excel®️ 2016. Resultados: Foi observado que 172 (18%) internações eram sensíveis a Atenção Primária, sendo a maior frequência dos casos relacionada a problemas no sistema respiratório (53,19%), Os dados apontaram que as internações são mais recorrentes no primeiro ano de vida (n=313/32%), sendo o maior percentual de pacientes do sexo masculino (n = 550/ 57%) em comparação ao sexo feminino (n= 419/43%), 857 (88,44%) receberam alta médica e todos os óbitos (n=4/0,4%) ocorreram na unidade de Pronto Socorro. Conclusão: Os resultados fornecem subsídio para gestão e organização do sistema de saúde e evidenciam a necessidade de fortalecimento da Atenção Primária.
Relationship between early weaning and common mental disorders in adolescents and adults: a literature review
Authors: Gomes Giovana Silva , Paz Diego Damasceno
Published: March 2023

The benefits of breastfeeding for the child and the mother are already well established in the literature. Recent studies indicate that the consequences of early weaning can affect not only childhood, but also adolescence and adulthood. Possible late consequences include an increased occurrence of long-term common mental disorders (CMD). However, there are few available data on this topic, which makes it necessary to carry out more research that seeks to evidence the association between breastfeeding and mental disorders. Therefore, this study aimed to carry out a literature review in order to relate early weaning with the occurrence of CMD. The search was carried out on the search portals PubMed, CENTRAL, SciELO and Lilacs. After searching with the descriptors, 3 articles were selected that matched the inclusion and exclusion criteria. The results indicate that prolonged breastfeeding has a protective effect on the mental health of adolescents and adults, being associated with lower risks of CMD occurrence.
Comportamentos de movimento de 24 horas em idosos: uma revisão sistemática
Authors: Andrade José François Alves de , Guarda Flávio Renato Barros da , Silva Valter Abrantes Pereira da , Ribeiro Maurício Maltez , Scher Luria Melo de Lima
Published: March 2023

O objetivo desta revisão sistemática foi sintetizar estudos que avaliaram as características do comportamento de movimento de 24 horas em idosos não institucionalizados. Trata-se de uma pesquisa conduzida em três bases de dados eletrônicas (PubMed, Web of Science e Scopus) no período de janeiro a março de 2022. Dos 395 estudos encontrados, 26 foram incluídos na análise final. Os estudos incluídos apresentaram boa qualidade metodológica (com pontuação ≥ a 70%), e foram realizados em 17 países diferentes. Nesses estudos foram utilizadas medidas objetivas (acelerômetros) e/ou subjetivas (questionários) para mensurar o comportamento de 24hs. Os achados apontam para um baixo nível de atividade física (AF), excesso no comportamento sedentário (CS) e alteração e/ou baixa qualidade de sono entre os idosos. Observou-se, também, entre os idosos, uma maior concentração no tempo dedicado ao CS, quando comparado ao tempo dedicado a atividade física regular, e ao sono. Contudo, há necessidade de mais estudos nessa área, em especial, estudos longitudinais e experimentais, com medidas objetivas e subjetivas para auxiliar na melhor compreensão dos comportamentos de 24 horas, e suas possíveis implicações na saúde do idoso.
Relação entre o antígeno glicolipídeo fenólico (PGL-I) e a detecção da hanseníase
Authors: Machado Giovanna Santana , Mendes Sarah Neres , Almeida Junior Roberto da Silva
Published: March 2023

Entender sobre as vantagens e desvantagens do antígeno glicolipídeo fenólico na detecção precoce da hanseníase. Essa pesquisa consiste em uma revisão integrativa da literatura, para a busca foi elaborada a pergunta norteadora utilizando os subsídios necessários para possibilitar a localização dos estudos disponíveis nas bases de dados: “Qual a relação entre o Antígeno glicolipídeo fenólico e o auxílio no diagnóstico da hanseníase?”. As bases utilizadas foram: National Library of Medicine National Institutes of Health (PubMed), Science Direct e Biblioteca Virtual em Saúde (BVS/MEDLINE). Os descritores e palavras-chave foram obtidos por consulta nos Descritores de Ciências em Saúde (DECS) e Medical Subject Headings (MeSH), os descritores foram “phenolic glycolipid I”, “leprosy”, “diagnosis”, “hanseníase” e “diagnóstico”. O estudo contou com uma amostra de 8 artigos, entre eles foram discutidos aspectos negativos e positivos do antígeno glicolipídeo fenólico para a detecção da hanseníase. Entre eles, foram elencados positivamente que os antígenos ajudam a indicar o diagnóstico precoce da doença, indica seu potencial de desenvolver reações mais severas, assim como auxilia o diagnóstico e prediz recaídas, já os pontos negativos elencados foram a baixa capacidade de detectar verdadeiras positivos, insuficiência diagnóstica e impossibilidade de iniciar terapêutica devido indicar apenas infecção prévia. É notório que mais estudos são necessários sobre a funcionalidade do antígeno glicolipídeo fenólico (PGL-I) na detecção precoce da hanseníase, devido à alta dicotomia entre aspectos negativos e positivos.
Retardo na progressão da doença renal crônica com o uso de inibidores do sglt2: revisão integrativa
Authors: Moreira Antônio Carlos Laender , Basniak Brenda Batista Ferreira , Basniak Leandro , Berci Manuela da Silva , Stival Thállyta Macedo
Published: March 2023

A Doença Renal Crônica (DRC), cuja principal causa é o diabetes mellitus do tipo 2 (DM2), é definida como a redução da taxa de filtração glomerular abaixo de 60ml/min/1,73m2 e/ou presença de albuminúria por pelo menos 3 meses. Atualmente, o uso de inibidores do co-transportador de sódio-glicose tipo 2 (ISGLT2) representa uma nova classe de medicamentos no tratamento da DRC, atuando como antagonistas dos receptores de SGLT2 nos rins. Objetivo: Esta revisão teve o objetivo de analisar e discutir acerca de pacientes com DRC tratados com inibidores do SGLT2 e seus desfechos renais. Realizou-se pesquisa de artigos científicos indexados na base de dados PubMed, sendo selecionados 190 artigos entre os anos de 2018 e 2022.  Metodologia: Os descritores utilizados, segundo o “DeCS/MeSH”, foram: Doença Renal Crônica; Gliflozinas; Taxa de Filtração Glomerular; Inibidor do SGLT2. Como critérios de inclusão dos estudos, inicialmente, determinou-se os seguintes parâmetros: idioma de publicação em português e inglês e tipo de estudo “Full Text” e “Randomized Controlled Trial”. Resultados: A amostra final desta revisão foi constituída por 13 artigos científicos, selecionados na plataforma PUBMED pelos critérios de inclusão previamente estabelecidos. Foram analisados 8 estudos clínicos randomizados duplo-cego, 1 declaração de posição de ensaios clínicos controlados por placebo, 2 análises de ensaios clínicos controlados por placebo e 2 estudos randomizados. Conclusão: O uso dos inibidores do SGLT2 melhora tanto os desfechos renais, como retarda a progressão da DRC em todas as categorias de risco do KDIGO, independentemente da presença de diabetes mellitus tipo 2.
Phosphate fertilization of Mesosetum chaseae in Roraima’s savannas
Authors: Costa Newton de Lucena , Magalhães João Avelar , Rodrigues Braz Henrique Nunes , Santos Francisco José de Seixas
Published: March 2023

The objective of this work was to evaluate the effect of phosphate fertilization (0, 30, 60 and 120 kg of P2O5 ha-1) on forage production and morphogenetic and structural characteristics of Mesosetum chaseae under natural field conditions in the savannas of Roraima. Phosphate fertilization positively and significantly (P<0.05) affected green dry matter (GDM) production, absolute growth rate (AGR), number of tillers plant-1, number of leaves tiller-1 (NLT), average leaf size (ALS), leaf tiller area (LTA), appearance rates (LAR), expansion (LER) and leaf senescence rates. The maximum yields of GDM, AGR, LAR, LER, NLT, LTA and ALS were obtained with the application of 89.17; 112.7; 47.7; 51.9; 102.9; 101.8 and 94.8 kg of P2O5 ha-1, respectively. The efficiency of P utilization was inversely proportional to the P doses applied.
Desenvolvimento de um aplicativo de food service para pizzarias do município de Princesa Isabel - PB
Authors: Almeida William Pereira de , Rique Thiago Pereira , Sobrinho Francisco Monte Sousa , Santos Klériston Christy Vital
Published: March 2023

Os serviços de delivery via dispositivos móveis já são uma realidade na sociedade moderna. No setor de alimentos, as empresas procuram investir em tecnologia com o objetivo de melhorar seus serviços, buscando vantagens em um mercado cada vez mais competitivo. A dificuldade de manter os clientes, gerenciar as demandas dos consumidores e aplicar promoções de uma maneira eficaz são apenas alguns dos obstáculos presentes neste cenário, além da forte concorrência, o que reforça a importância dos aplicativos de delivery como uma ferramenta poderosa para auxiliar as empresas a se manterem no mercado. No entanto, em cidades menos desenvolvidas ainda há uma carência de tecnologia para ajudar os pequenos empresários nesse ramo, como é o caso do município de Princesa Isabel, Paraíba, Brasil. Nesse contexto, este trabalho busca demonstrar os passos utilizados para criação de um aplicativo de delivery para pizzarias que tem como objetivo resolver ou diminuir os problemas apresentados. O desenvolvimento de tal aplicativo representa uma nova solução para os comerciantes e consumidores no ramo de pizzarias de Princesa Isabel e região, que buscam praticidade e conveniência na hora de realizar os pedidos, fornecendo segurança e privacidade para as partes envolvidas.
Aplicabilidade da escala de Fugulin: uma revisão integrativa
Authors: Gâmbaro Lívia , Rossi Selma Gentil , Simonetti Sérgio Henrique
Published: March 2023

Objetivo:  Buscar evidências na literatura sobre a aplicabilidade da Escala de Fugulin. Método: Revisão integrativa da literatura que incluiu artigos originais das bases de dados MEDLINE, LILACS e BDENF, no recorte temporal de 2012 a 2022. A síntese dos artigos foi feita de forma descritiva segundo o tipo de abordagem. Resultados: Foram identificados 1731 artigos, dos quais 5 foram incluídos na presente revisão, publicados em idioma inglês, todos no Brasil. Todos os artigos buscaram avaliar o nível de complexidade assistencial dos pacientes em unidades de internação hospitalar e associar com o dimensionamento de enfermagem da unidade. A aplicação da escala de forma tecnologia sistematizada permitiu acesso a resultados importantes em tempo real com impacto em economia de tempo e custo. Conclusão: Conclui-se que a utilização da Escala de Fugulin se mostra eficaz em fornecer informações acerca do perfil assistencial a partir da classificação do grau de dependência dos pacientes. A escala aplicada de forma tecnológica está relacionada com a otimização do tempo, processo de tomada de decisão e impacto em custos e energia.
Autotransplante dentário – reabilitação e inclusão social: uma revisão integrativa
Authors: Barbosa Karla C. T. de S. B. , Assis Tamara Saraiva de , Nunes Filipe Bonfim , Faria Marcelo Domingues de
Published: March 2023

O autotransplante dentário é uma técnica cirúrgica na qual um dente é removido do seu lugar original e passa a ocupar outro espaço em uma das arcadas do mesmo paciente. Geralmente, esses novos espaços são áreas estéticas, como a extensão da linha do sorriso, ou em áreas de maior funcionalidade. Os traumatismos que resultam em perdas dentárias, as agenesias, extensas e irreversíveis destruições por cáries, podem requerer processos reabilitadores de alto custo, demorados e muitas vezes ineficientes, circunstâncias que acabam por impor ao indivíduo uma aceitação forçada de sua condição: estética comprometida, subfunção mastigatória e de fonação, e assim, ocasionar baixa autoestima. Neste sentido, o presente artigo objetivou realizar uma revisão integrativa sobre o autotransplante, destacando as vantagens e desafios frente às inúmeras evoluções da técnica na esfera privada em detrimento das restrições e limitadas possibilidades do serviço público. Porém, a pesquisa demonstrou sua viabilidade, passível de ser ofertada pela atenção especializada/SUS. Foram apresentados os resultados textuais da literatura publicados nos últimos 10 anos, sendo que para a construção dessa revisão, foram utilizadas as bases de dados: PubMED, Scientific Electronic Library Online (SciELO) e Google acadêmico, com artigos em inglês e português. Trinta e dois artigos foram analisados, os quais revelaram a possível aplicabilidade da técnica cirúrgica pelo serviço público, o que permitirá uma melhoria na qualidade de vida dos indivíduos submetidos à cirurgia, garantindo-lhes integralidade do cuidado e inclusão nos ciclos de representatividade sociais.
Sequential production of two biopolymers-polyhydroxyalkanoate and levan by microbial fermentation
Authors: Siqueira Edmilson Clarindo de , Houllou Laureen Michelle
Published: March 2023

The sequential production of polyhydroxyalkanoates (PHA) and levan was investigated by microbial fermentation using agro-industrial residues. PHA production was carried out by Cupriavidus necator DSMZ 545 in two steps: a) bacterial growth, using pure (MN) and hydrolyzed (MH) molasses and; b) accumulation of PHA, using standard glycerol (GP) and crude glycerol (GB). The fermented remaining from the C. necator growth stage was separated from the PHA-containing biomass and used in the subsequent production of levan by Bacillus subtilis (natto) Takahashi. The medium containing MH+GP generated a rate of 15 mg of PHA, while the medium based on MH+GB the rate of PHA was almost twice as high (28.4 mg). FTIR spectroscopic analysis of PHA indicated stretching vibrations characteristic for a PHB-like molecule. In turn, the levan produced in this study was precipitated with different volumes of ethanol, generating levans with different molecular weights. The results of the characterization of this fructan by chromatography showed that it was predominantly constituted by fructose units. In addition, the dynamic and kinematic viscosity values for levan were similar in the analyzed concentrations and, therefore, did not provide any clues about the molecular weight of this biopolymer. Finally, the sequential production process of PHA and levan, as a second bioproduct, represents an elegant alternative to reduce the total costs of PHA production.
Atributos da Atenção Primária à Saúde no Cuidado de Crianças em São Paulo/ SP
Authors: Silva Bruna Isabele Gomes da , Ayello Pietra Ribeiro , Monteiro Camila Nascimento , Mafra Ana Carolina  Cintra Nunes , Almeida Letícia Yamawaka de , Peres Neto João
Published: March 2023

O objetivo foi avaliar os atributos da Atenção Primária à Saúde (APS) no cuidado das crianças em Unidades Básicas de Saúde (UBS). Estudo transversal com abordagem quantitativa, desenvolvido em 13 UBS no município de  São Paulo/ SP, no ano de 2021. Para a avaliação dos atributos da APS foi utilizado o instrumento  PCATool-Brasil para crianças. Foram avaliados os escores de cada atributo separadamente e também os escores geral e essencial. A amostra foi caracterizada a partir da média e desvio padrão, mínimo e máximo, mediada e quartis, para as variáveis quantitativas, e pelas frequências absolutas e relativas para as variáveis qualitativas. Participaram 242 crianças, com idade média de 3,33 anos e os escores essencial com valores de (6,41) e geral (6,20) respectivamente. Os resultados dos escores apresentaram-se baixos e, portanto, com necessidade de melhorias nos serviços da APS. Os resultados dos escores essencial e geral apresentados como baixos e, portanto, com necessidade de melhorias nos serviços da APS evidenciam à busca constante por avaliações dos mesmos, objetivando uma gestão qualificada e que traga uma maior resolutividade à APS.
Caracterização sociodemográfica e perfil do paciente com dislipidemia de Unidades Básicas de saúde de um município do sudoeste da Bahia
Authors: Brandão Décio Adir Vieira , Romão Roney Vieira , Castro Mariana Cristina Souza , Rodrigues Ramaion Oliveira , Malheiro Luane Costa Pereira , Prado Camila Dourado , Silva Vânia Olímpia Barbosa , Cruz André Fabricio Pereira da
Published: March 2023

Objetivo: Avaliar os fatores associados ao perfil e à distribuição sociodemográfica do paciente com dislipidemia atendidos pelas Unidade Básica de Saúde do município de Guanambi/BA. Métodos: Trata-se de uma pesquisa descritiva, com análises quantitativas de campo. Os sujeitos da pesquisa foram 63 pacientes dislipidêmicos, acompanhados por Unidades Básicas de Saúde do município, selecionados aleatoriamente sendo aplicado um questionário com perguntas diretas e objetivas relacionadas aos interesses do estudo. O procedimento utilizado respeitou e considerou as normas internacionais de experimentação com humanos, tendo sido aprovado pelo Comitê de Ética. Resultados e Conclusão: Evidenciou-se que a dislipidemia é mais presente em indivíduos acima de 65 anos, com porcentagem elevada de sujeitos sedentários e com sobrepeso, sendo a sinvastatina o medicamento mais utilizado durante o tratamento. Percebeu-se, também, a ocorrência de efeitos colaterais em uma pequena parcela da população pesquisada.
The early-life microbiota in relation to mucosal immune maturation and respiratory infections in children
Authors:   , de Koff Emma Margaretha
Published: March 2023

The development of the human microbiome starts at birth with the partially transmitted microbiota from mother to child and continues in the first years of life under the influence of factors like nutrition, daycare attendance and antibiotics use. An increasing number of studies imply a relationship between the composition of the microbiome in early life and the risk of developing both infectious diseases and immune-mediated chronic disorders, such as asthma and allergies, in later life. In this thesis, we studied correlations of the early-life composition of the upper respiratory and intestinal microbiome with mucosal antibody concentrations and salivary antibody responses to routinely administered vaccines, respectively. These studies suggested that a microbiome with a higher abundance of beneficial bacteria in the first weeks of life, which was more often found in infants who were born via vaginal delivery in contrast to caesarian section and who were breastfed, might be favorable for the early development of antibody responses. Furthermore, we demonstrated that the respiratory microbiome composition was heavily disrupted during severe respiratory infections requiring hospitalization, but recovered well after the acute infection, albeit not in all children. Diminished recovery of the microbiome following a severe respiratory infection was, in turn, associated with more frequent recurrence of respiratory complaints. Finally, we showed that saliva could be more frequently considered as a non-invasive specimen in infection and immunity research. In conclusion, this thesis proposes leads for further research to develop methods to manipulate the early-life microbiome and potentially attain a beneficial effect on child health.
Insulation Coordination of a UHV AC Transmission Line Considering the Switching Overvoltage Waveshape
Authors: Reddy A. Ramchandra
Published: March 2023

This paper presents the determination of insulation coordination for phase-to-ground switching over voltages by a practical method in which the effect of the switching overvoltage waveshape, especially the impact of the time to crest on insulation strength is considered. This work is carried out on the world’s first 1200 kV transmission line by modelling it in PSCAD.
Dissolved Gas Analysis is an Art of Testing and Analysis Method for the Incipient Faults in Power Equipment - Like Transformers and OLTCs
Authors: Singh Ramjeet
Published: March 2023

This paper describes the importance of Testing and Analysis of Dissolved Gases in oil-filled electrical power equipment like transformers and OLTCs and maintenance practices adopted based on DGA test results; the case studies wherein faults predictions and or confirmation of faults suggest for further maintenance or actions to be taken to remain the system functional for long life. The paper mentions the various methodology being adopted for the interpretation of DGA test results to conclude the type of faults in the equipment and a comparative study of DGA test results based on proficiency test results carried out by International laboratories concluding a similar type of fault indicating international acceptance of DGA testing of oil filled power equipment.
Development of a Tape Winding Mechanism for HTS Power Cables
Authors: De Souza Isaac , Anand Ankit , Singh Gour Abhay , Vasudeva Rao Vutukuru
Published: March 2023

Manufacturing of HTS power cables requires winding the HTS tapes helically around a former. These HTS tapes are costly, and delicate and require sophisticated winding machinery which is expensive. In this paper, an in-house economic mechanism for converting a conventional lathe machine to a Tape Winding Mechanism (TWM) is discussed in detail. In addition to the developed prototype, the technical issues and challenges encountered during the development of TWM are listed. The developed TWM was instrumental in successfully winding 10 HTS tapes simultaneously around a tin-coated braided copper former of 19 mm diameter with a pitch length of 210 mm for a continuous length of 5 m HTS cable. The recommendation of modifying any existing cable winding machine to TWM is also discussed.
Battery Swapping Stations- A Viable Option for Faster Adoption of EVs in India
Authors: Jeykishan Kumar K. , Singh Rana Kuldeep
Published: March 2023

Total electrification of road transport has its own major constraints. The industry struggles to reduce the plug-in charging times and impact on the grid of battery-powered electric vehicles. Battery swapping is one of the best concepts to overcome the constraints where Vehicles swap low state charge batteries for charged ones at Battery Swapping Stations (BSS). A Battery Swapping Stations (BSS) is a charging place/fuelling station equipped with number of standards and certified charging units and battery swapping robots. A BSS has a certain amount of battery inventory of fully charged batteries of different sizes and types thus providing a faster and intermediate service to the customer looking for recharging their batteries. This paper studies the challenges and opportunities for the use of BSS in India.
DISTINCTIVE FEATURES OF THE NEW VARIETY FESTULOLIUM AYVENGO
Authors: Zolotarev Vladimir , Trukhan Olga , Korovina Valentina
Published: March 2023

Festulolium (× Festulolium F. Aschers. et Graebn.) is a new crop, the varieties of which are created by the method of species hybridization in the Lolium and Festuca genus system. A new amphidiploid cultivar Ayvengo was obtained as a result of intergeneric hybridization of multi-cutting ryegrass and reed fescue (Lolium multiflorum Lam. × Festuca arundinacea Schreb. subsp. arundinacea). Registered in the State Register since 2022. Tetraploid variety of ryegrass morphotype. It is characterized by a combination of fodder advantages of multicut ryegrass with winter hardiness, drought resistance and longevity of cane fescue, high ecological plasticity. According to the type of development, it belongs to winter plants and does not form generative shoots in the year of sowing. Differs in resistance to diseases, competitiveness in grass mixtures, fast and intensive regrowth after grazing or mowing. Distinctive morphological features, features of growth and development of this variety, as well as its fodder qualities, productivity, chemical composition of green mass, its advantages and differences from the standard festulolium variety VIK 90 are given. The seed yield of the Ayvengo variety, on average, for two tabs of the competitive variety trial was: in the first year of use 1.09 t/ha, in the second year — 0.66 t/ha and in the third year — 0.34 t/ha. On average, over the three years of use, the seed yield was 0.70 t/ha, which is 10% more than the standard variety VIK 90. In terms of feed quality and fodder productivity, hay yield, the new variety is 10.7–19.9% higher than standard and analogues of varieties of the original parental forms.
A novel model extended from the Bouguer-Lambert-Beer law can describe the non-linear absorbance of potassium dichromate solutions and microalgae suspensions
Authors: Yeh Yen-Cheng , Haasdonk Bernard , Schmid-Staiger Ulrike , Stier Matthias , Tovar Günter E. M.
Published: March 2023

Introduction: The Bouguer-Lambert-Beer law is widely used as the fundamental equation for quantification in absorption spectroscopy. However, deviations from the Bouguer-Lambert-Beer law have also been observed, such as chemical deviation and light scattering effect. While it has been proven and shown that the Bouguer-Lambert-Beer law is valid only under very restricted limitations, there are only a few alternatives of analytical models to this law. Based on the observation in the experiments, we propose a novel model to solve the problem of chemical deviation and light scattering effect.

Methods: To test the proposed model, a systematic verification was conducted using potassium dichromate solutions and two types of microalgae suspensions with varying concentrations and path lengths.

Results: Our proposed model demonstrated excellent performance, with a correlation coefficient (R2) exceeding 0.995 for all tested materials, significantly surpassing the Bouguer-Lambert-Beer law, which had an R2 as low as 0.94. Our results confirm that the absorbance of pure pigment solutions follows the Bouguer-Lambert-Beer law, while the microalgae suspensions do not due to the light scattering effect. We also show that this scattering effect leads to huge deviations for the commonly used linear scaling of the spectra, and we provide a better solution based on the proposed model.

Discussion: This work provides a powerful tool for chemical analysis and especially for the quantification of microorganisms, such as the concentration of biomass or intracellular biomolecules. Not only the high accuracy but also the simplicity of the model makes it a practical alternative to the existing Bouguer-Lambert-Beer law.
Magnetic iron oxide nanoparticle-loaded hydrogels for photothermal therapy of cancer cells
Authors: Ji Yunfei , Wang Chunpu
Published: March 2023

Introduction: Non-invasive photothermal therapy (PTT) is a competitive treatment for solid tumors, while the efficacy is largely dependent on the effective retention of photothermal converters in tumor tissues.

Methods: Herein, the development of iron oxide (Fe3O4) nanoparticle-loaded alginate (ALG) hydrogel platform for PTT of colorectal cancer cells is reported. Fe3O4 nanoparticles synthesized via coprecipitation method after reaction of 30 min have a small size (61.3 nm) and more suitable surface potential, and can mediate PTT under near-infrared (NIR) laser irradiation. The premix of Fe3O4 nanoparticles and ALG hydrogel precursors can be gelatinized by Ca2+-mediated cross-linking to form this therapeutic hydrogel platform.

Results: The formed Fe3O4 nanoparticles can be effectively taken up by CT26 cancer cells and induce the death of CT26 cells in vitro under NIR laser irradiation because of their excellent photothermal property. In addition, Fe3O4 nanoparticle-loaded ALG hydrogels show negligible cytotoxicity at the studied concentration range, but can significantly kill cancer cells after PTT effect.

Conclusion: This ALG-based hydrogel platform provides a valuable reference for subsequent in vivo studies and other related studies on Fe3O4 nanoparticle-loaded hydrogels.
Biodegradable hollowed mesoporous SeO2 nanoplatform loaded with indocyanine green for simultaneous NIR II fluorescence imaging and synergistic breast carcinoma therapy
Authors: Peng Tingwei , Liu Qing , Song Hui , Zhang Conghui , Wang Xue , Ru Ping , Xu Tianzhao , Liu Xinghui
Published: March 2023

Contrast agents in the second window of the near-infrared region (NIR II, 1000–1700 nm) have several advantages and indocyanine green (ICG), which emits NIR II fluorescence, is clinically approved and its use has been widely investigated for in vivo imaging, specifically for delineating tumor outlines; however, insufficient tumor targeting and rapid physiological metabolism of free ICG has substantially impeded its further clinical application. Here, we constructed novel hollowed mesoporous selenium oxide nanocarriers for precise ICG delivery. After surface modification with the active tumor targeting amino acid motif, RGD (hmSeO2@ICG-RGD), the nanocarriers were preferentially targeted toward tumor cells and subsequently degraded for ICG and Se-based nanogranule release under tumor tissue extracellular pH conditions (pH 6.5). The released ICG acted as an NIR II contrast agent, highlighting tumor tissue, after intravenous administration of hmSeO2@ICG-RGD into mammary tumor-bearing mice. Importantly, the photothermal effect of ICG improved reactive oxygen species production from SeO2 nanogranules, inducing oxidative therapy. The synergistic therapeutic effects of hyperthermia and increased oxidative stress on 808 nm laser exposure induced significant tumor cell killing. Thus, our nanoplatform can generate a high-performance diagnostic and therapeutic nanoagent that facilitates in vivo tumor outline discrimination and tumor ablation.
Current perspectives of mitochondria-targeted antioxidants in cancer prevention and treatment
Authors: Zinovkin Roman A. , Lyamzaev Konstantin G. , Chernyak Boris V.
Published: March 2023

Oxidative stress nearly always accompanies all stages of cancer development. At the early stages, antioxidants may help to reduce reactive oxygen species (ROS) production and exhibit anticarcinogenic effects. In the later stages, ROS involvement becomes more complex. On the one hand, ROS are necessary for cancer progression and epithelial-mesenchymal transition. On the other hand, antioxidants may promote cancer cell survival and may increase metastatic frequency. The role of mitochondrial ROS in cancer development remains largely unknown. This paper reviews experimental data on the effects of both endogenous and exogenous antioxidants on cancerogenesis focusing on the development and application of mitochondria-targeted antioxidants. We also discuss the prospects for antioxidant cancer therapy, focusing on the use of mitochondria-targeted antioxidants.
MAPKs in the early steps of senescence implemEMTation
Authors: Anerillas Carlos , Altés Gisela , Gorospe Myriam
Published: March 2023

Evidence is accumulating that the earliest stages of the DNA damage response can direct cells toward senescence instead of other cell fates. In particular, tightly regulated signaling through Mitogen-Activated Protein Kinases (MAPKs) in early senescence can lead to a sustained pro-survival program and suppress a pro-apoptotic program. Importantly, an epithelial-to-mesenchymal Transition (EMT)-like program appears essential for preventing apoptosis and favoring senescence following DNA damage. In this review, we discuss how MAPKs might influence EMT features to promote a senescent phenotype that increases cell survival at the detriment of tissue function.
Decidual cells and decidualization in the carnivoran endotheliochorial placenta
Authors: Diessler Mónica Elizabeth , Hernández Rocío , Gomez Castro Gimena , Barbeito Claudio Gustavo
Published: March 2023

Decidualization is considered a distinctive feature of eutherian pregnancy, and has appeared during evolution along with the development of invasive forms of placentation, as the endotheliochorial placenta. Although decidualization is not massive in carnivores, as it is in most species developing hemochorial placentas, isolated or grouped cells regarded as decidual have been documented and characterized, mainly in bitches and queens. For the majority of the remaining species of the order, data in the bibliography are fragmentary. In this article, general morphological aspects of decidual stromal cells (DSCs), their time of appearance and lasting, data about the expression of cytoskeletal proteins and molecules considered as markers of decidualization were reviewed. From the data reviewed, it follows that carnivoran DSCs take part either in the secretion of progesterone, prostaglandins, relaxin, among other substances, or at least in the signaling pathways triggered by them. Beyond their physiological roles, some of those molecules are already being used, or are yet under study, for the non-invasive endocrine monitoring and reproductive control of domestic and wild carnivores. Only insulin-like growth factor binding protein 1, among the main decidual markers, has been undoubtedly demonstrated in both species. Laminin, on the contrary, was found only in feline DSCs, and prolactin was preliminary reported in dogs and cats. Prolactin receptor, on the other hand, was found in both species. While canine DSCs are the only placental cell type expressing the nuclear progesterone receptor (PGR), that receptor has not been demonstrated neither in feline DSCs, nor in any other cell in the queen placenta, although the use of PGR blockers leads to abortion. Against this background, and from the data gathered so far, it is unquestionable that DSCs in carnivorans do play a pivotal role in placental development and health. The knowledge about placental physiology is critical for medical care and breeding management, primarily in domestic carnivores; it is also absolutely crucial for a conservation approach in the management of endangered carnivore species.
Clinical features and diagnostic value of metagenomic next -generation sequencing in five cases of non-HIV related Pneumocystis jirovecii pneumonia in children
Authors: Niu Jiechao , Wang Jiandong , Jia Peisheng , Zhang Mengjiao , Wei Erhu
Published: March 2023

Background

Pneumocystis jirovecii (PJ) is an opportunistic pathogenic fungus, and PJ pneumonia (PJP) is a commonly problem in HIV-positive patients. While PJP is not caused by HIV, it generally advances rapidly and can quickly lead to severe respiratory failure. To improve pediatricians’ understanding of the condition and aid early accurate diagnoses and therapy, we examined the clinical characteristics of five instances of non-HIV related PJP (NH-PJP) in children and the efficacy of metagenomic next-generation sequencing (mNGS) in its diagnosis.

Methods

From January 2020 to June 2022, five children with NH-PJP were admitted to the PICU of the First Affiliated Hospital of Zhengzhou University. We retrospectively summarize the clinical presentation, previous histories, routine laboratory findings, treatment, outcome of regression, and results of mNGS in these five children.

Results

Five male children between the ages of 11 months and 14 years had an acute onset on NH-PJP, three of the children had chest tightness after activity, shortness of breath and paroxysmal dry cough, — and two had high fever and dry cough. All five of the children had several flocculent high-density pictures in both lungs at the beginning of the disease, and lung auscultation revealed coarse breath sounds in both lungs, one of which was accompanied by a modest quantity of dry rales. PJ nuclear sequences were found in one patient and four patients’ blood and alveolar lavage fluid. All five children were treated with Trimethoprim-sulfamethoxazole (TMP-SMX) in combination with Caspofungin and corresponding symptomatic treatment. Four patients were cured and one patient died.

Conclusion

Children commonly encounter an initial exposure to NH-PJP, which manifests as a high fever, dry cough, chest discomfort, dyspnea that worsens over time, fast disease progression, and a high death rate. The clinical presentation of children with PJ infection should be taken into consideration along with the results for diagnose. mNGS has higher sensitivity and a shorter detection period compared to identification of PJP.
GR2L: A robust dual-layer green roof water balance model to assess multifunctionality aspects under climate variability
Authors: Knappe Jan , van Afferden Manfred , Friesen Jan
Published: March 2023

Urban blue-green infrastructures (BGIs) fulfill a variety of functions that enable cities to cope with climate change and additional urban anthropogenic pressures such as increasing population density, heat island effects, biodiversity loss, and progressive sealing of permeable surfaces. In the urban water cycle, BGIs can play an important role when it comes to both managing and mitigating the direct effects of ever-increasing periods of extended drought as well as the temporary excess of stormwater during and after heavy rainfall events. Although BGIs are multifunctional in principle, the individual infrastructure has to be designed and operated toward achieving a set of specific objectives, e.g., stormwater retention, infiltration, or storage for increased overall water resilience. In this study, we focus on green roofs as a key BGI for water resilient urban spaces. Green roofs have the advantage of unlocking underutilized roof space for urban water management and additional co-functions, avoiding additional urban land use conflicts at ground level. Green roofs are available in a multitude of design types based on the selection of vegetation, the make and thickness of the substrate layer, and the absence or presence of additional retention space. With GR2L, we present a robust dual-layer green roof water balance model that is able to cope with a variety of design aspects and was validated and calibrated using a data set of four green roof types with varying technical specifications and different vegetation cover. We used the calibrated models to assess how different green roof types operate under variable climatic conditions using meteo ensembles that consist of dry and wet years as well as a suite of randomly selected years. Calibration results indicate that a green roof factor (based on the classic crop factor) largely depending on the retention capacity of green roofs, makes the results widely applicable in planning. The results provide information on how green roof designs can be optimized for fulfilling a given set of water balance-driven multifunctionality objectives under varying climatic conditions and enabling an assessment of the performance of existing green roof designs against these conditions.