bluuebunny/crossref_metadata_2025 huggingface dataset:
Sleep pattern, obesity and healthcare expenditures in Brazilian adults
Authors: Silva Eduardo Pereira da , Rocha Ana Paula Rodrigues , Araujo Monique Yndawe Castanho , Turi Bruna Camilo , Fernandes Rômulo Araújo , Codogno Jamile Sanches
Published: October 2019

Abstract The aim of this study was to analyze the relationship between sleep pattern and healthcare expenditures in adults, as well as to identify whether physical activity, biochemical markers and obesity affect this relationship. The sample was composed of 168 adults aged ≥ 50 years attended by two Basic Healthcare Units in Presidente Prudente, SP, Brazil. Health expenditure, sleep pattern, anthropometry, adiposity index, physical activity, metabolic and cardiovascular variables were assessed. Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney and Spearman tests. Sleep disorders were positively correlated to higher costs with medicines and negatively correlated to costs with laboratory tests, even after adjusts by confounders. In addition, healthcare costs were also correlated to physical activity score, blood pressure, obesity and metabolic variables. Severe sleep disorders and high percentage of body fat were associated with increased use of medications. Sleep pattern is correlated to primary care healthcare costs, obesity and physical activity level.
Profile of nursing graduates: competencies and professional insertion
Authors: Barbosa Amanda Conrado Silva , Luiz Franciane Silva , Friedrich Denise Barbosa de Castro , Püschel Vilanice Alves de Araújo , Farah Beatriz Francisco , Carbogim Fábio da Costa
Published: October 2019

Objective: evaluate the profile of the graduates of Nursing a public college from the perception of skills developed during graduation and the process of professional insertion. Method: quantitative, exploratory and descriptive study. The sample was composed of 216 graduates. The data was collected by a validated questionnaire and sent to a population of 470 egresses via electronic mail. For the analysis of the data, frequencies, mean and standard deviation were applied and, for the correlation, the chi-square test. Results: the majority of the participants were female (88%) and the mean age was 29.62 years. The majority (65%) had an employment relationship, 14% worked in a single institution and 48% started working six months after graduation. Regarding the form of work, 56% work in care, with an average of 4.5 minimum wages and a weekly workload between 37 and 44 hours. The majority reported competence acquisition to practice the profession, assisting the patient in his integrality with ethics and applying technical and scientific concepts in care. Conclusion: the study made it possible to describe the singularities of nurses’ education, their insertion in the world of work and the impact on the educational institution, as well as the presentation of specific competences from the perspective of the graduates themselves.
Bactérias zoonóticas isoladas de Passeriformes silvestres recuperados do tráfico de animais no estado do Ceará/Brasil
Authors: Gaio F.C. , Lopes E.S. , Lima B.P. , Carmo C.C. , Marques A.R. , Oliveira F.R. , Amaral M.S.M.G. , Pascoal Filho N.M. , Carreira A.S. , Beleza A.J.F. , Teixeira R.S.C. , Havt A. , Maciel W.C.
Published: October 2019

RESUMO A ordem dos Passeriformes é uma das mais pressionadas pelas ações antrópicas, especialmente as relativas ao tráfico de animais, que, devido às más condições de manejo e higiênico-sanitárias, favorecem a infecção dos espécimes por patógenos virulentos e zoonóticos, como cepas de Escherichia coli e Salmonella spp., cujo isolamento em suabes cloacais, bem como a análise dos genes de virulência das cepas de E. coli foram objetivos do estudo. Para isso, 120 Passeriformes silvestres nativos, recebidos pelo Cetas/CE, foram avaliados individualmente. As cepas isoladas foram submetidas a teste de disco difusão para determinação da sensibilidade aos antimicrobianos. Em etapa posterior, foi realizada PCR para a detecção de oito genes de virulência dos principais patotipos diarreiogênicos de E. coli. Quanto aos resultados, nenhuma cepa de Salmonella spp. foi isolada, no entanto a ocorrência de E. coli foi de 40,8%. Foi observada elevada resistência, principalmente aos antimicrobianos tetraciclina, ampicilina e sulfazotrim, ocorrendo multirresistência em 42,8% das cepas. Pela análise molecular, foram diagnosticados quatro entre os nove genes pesquisados, com a identificação de EPEC típicas, EPEC atípicas, ETEC, EHEC e EAEC. Os resultados apontam para a importância de Passeriformes como possíveis disseminadores de zoonoses.
Melanin bleaching with potassium permanganate for melanocytic lesions diagnosis in veterinary medicine
Authors: Moreira T.A. , Blanca W.T. , Gundim L.F. , Castro I.P. , Medeiros-Ronchi A.A.
Published: October 2019

ABSTRACT The aim of this study was to microscopically re-evaluate the melanocytic lesions diagnoses established by the Animal Pathology Laboratory of the Federal University of Uberlândia, in the state of Minas Gerais, Brazil, over a period of eleven years; in addition, to perform a comparative analysis between the conventional histopathological (CH) method and the use of the melanin bleaching (MB) technique with potassium permanganate, sulfuric acid, and oxalic acid solutions. The results of the MB method presented a disagreement in 24.32% of the diagnosis previously by CH, with low agreement (61.0%) and low Kappa coefficient (0.2267). Melanoma was the most frequent lesion, more frequent in elderly and non-breed female dogs. The most frequent melanoma location was in the cutaneous tissue. The presence or absence of a pagetoid spread in cutaneous samples, distribution of melanin, pattern of cell layout, cell morphology, degree of cellular atypia, and the number of mitoses verified after MB were the most important criteria to confirm the diagnosis of malignancy or benignity of the lesions. Evaluating pathologists considered MB to be essential for the majority of diagnoses and an efficient complementary method for the diagnosis of melanocytic lesions, even in cases with a moderate degree of pigmentation.
Hematological and biochemical parameters in Spotted Paca (Cuniculus paca) undergoing pharmacological restraint and general anesthesia
Authors: Uscategui R.A.R. , Santos V.J.C. , Almeida V.T. , Barros F.F.P.C. , Kawanami A.E. , Cruz N.R.N. , Feliciano M.A.R. , Vicente W.R.R.
Published: October 2019

ABSTRACT The aim of this study was to assess the effects of chemical restraint, general anesthesia and opioid treatment on hematological components in Cuniculus paca. Eight healthy, adult, captivity female animals , underwent three laparoscopic procedures with a 15-day interval were evaluated. After physical restraint, an association of ketamine (25mg/kg) and midazolam (0.5mg/kg) was administered intramuscularly for chemical restraint. Posteriorly, anesthesia was induced and maintained with isoflurane; and randomly administered methadone (0.5mg/kg), tramadol (5mg/kg) or saline-placebo (0,1mL/kg) intramuscularly. After pharmacological restraint and in the final laparoscopy stage, venous blood samples were obtained for complete blood count, total plasma protein (TP), creatinine, alanine aminotransferase (ALT), sodium, potassium, chloride and ionized calcium analysis. During general anesthesia, hemoglobin, TP concentration and lymphocytes decreased (P=0.029; <0.001; 0.022 respectively), whereas the potassium levels increased (P=0.034). In conclusion, chemical restraint with ketamine/midazolam association causes a slight decrease in blood cellular components. Isoflurane anesthesia for laparoscopic procedure lead to decrease in hemoglobin, lymphocytes and protein concentrations, while potassium increased, without any influence from the tramadol or methadone treatment. However, these alterations were transient, and its hematologic values can collaborate in carrying out epidemiological, pathophysiological or case studies in the Cuniculus paca.
Histological and immunohistochemical evaluation of two cell therapy protocols in equine suspensory ligament repair
Authors: Garbin L.C. , Soares A.S. , Mendes H.M.F. , Cassali G.D. , Vasconcelos A.C. , Faleiros R.R.
Published: October 2019

ABSTRACT This study aimed to histologically evaluate the quality of tissue repair in equine suspensory ligament treated with two cell therapy protocols. All four limbs of six animals were operated simultaneously to remove a fragment in each ligament using a skin biopsy punch. Two days later, intralesional injections were performed using bone marrow mononuclear fraction (BM group), cultivated cells derived from adipose tissue (AT group), saline (positive control group), or no treatment (negative control group), in such way that each horse received all treatments. After sixty days biopsies were performed for histological analysis (H & E, Masson’s trichrome and picrosirius red) and immunohistochemistry analysis (collagen type III). Histological findings (H & E and Masson’s trichrome), birefringence intensity (through picrosirius) and collagen type III expression (through immunohistochemistry) were analyzed. Samples from treated groups had better birefringence intensity (P=0.007) and fiber alignment scores were superior compared to controls, though not statistically significant (P=0.08). Presence of inflammatory cells and intense staining for collagen type III occurred in all groups demonstrating an active healing process. In conclusion, both protocols resulted in improvement of tissue repair indicating their potential to be used as an adjuvant treatment of equine suspensory ligament disorders.
Apparent selectivity of sheep in deferred marandu palisadegrass pastures with variable initial heights
Authors: Santos M.E.R. , Afonso L.E.F. , Carvalho B.H.R. , Rêgo A.C. , Queiroz G.J.S. , Medica J.A.S. , Moraes L.S. , Carmo L.L.S.
Published: October 2019

ABSTRACT The objective of this study was to evaluate the apparent selectivity of sheep in marandu palisadegrass (Urochloa brizantha cv. Marandu) pastures with four heights at the beginning of the deferment period (15, 25, 35 and 45cm). The deferment period was 92 days and started on 03/21/2014. Evaluations occurred in the beginning (first week), middle (45th day) and end (92nd day) of the grazing period, in winter (06/21/2014 to 09/21/2014). Deferred pastures with 15 and 25cm presented lower forage mass (FM), but higher live leaf (LL) percentage in FM than deferred pastures with 35 and 45cm. The live stem percentage in the FM and the apparent selectivity index (ASI) of the LL were superior in the deferred pasture with 45cm. The dead stem (DS) percentage in the grazing simulation (GS) and the ASI of this morphological component were lower in the pasture with 15cm, compared to the deferred pasture with 45cm. The FM and the LL percentages in FM and in the GS sample decreased, while the DS percentages in FM and in GS sample increased with the grazing period. Marandu palisadegrass with 15cm at beginning of the deferment period improves the morphology of the deferred pasture. Selective grazing is difficult during the grazing period.
Valor nutritivo do capim-xaraés em três intensidades luminosas
Authors: Barros J.S. , Meirelles P.R.L. , Gomes V.C. , Pariz C.M. , Fachiolli D.F. , Santana E.A.R. , Gomes T.G.J. , Costa C. , Castilhos A.M. , Souza D.M.
Published: October 2019

RESUMO Este trabalho teve como objetivo avaliar o valor nutritivo e a força de cisalhamento da cultivar de Urochloa brizantha (syn Brachiaria brizantha) cv Xaraés submetida a três intensidades luminosas e quatro cortes. O experimento foi conduzido na FMVZ - Unesp de Botucatu, com delineamento experimental em blocos ao acaso, sendo os tratamentos: luminosidade natural, redução de 30% e 60% de luz, com quatro cortes e três repetições. As análises realizadas foram: composição bromatológica, digestibilidade e a força de cisalhamento. Não houve diferença na digestibilidade entre os tratamentos em nenhum dos cortes, mas a qualidade forrageira foi influenciada pelos níveis de intensidade de luz, tendo o tratamento com 60% de redução de luminosidade apresentado maiores concentrações de proteína bruta e cinzas, menores teores de fibra em detergente neutro, hemicelulose, celulose e força de cisalhamento. Em relação aos cortes estudados, o primeiro teve o menor intervalo de corte e produziu forragem com qualidade superior em comparação ao último, pois obteve menor teor de fibra em detergente ácido, lignina, hemicelulose, celulose e consequente menor força de cisalhamento. Portanto, a redução de 60% de luminosidade é benéfica à qualidade e à força de cisalhamento da cultivar Xaraés.
Intussuscepção uterina em uma cadela sem raça definida - relato de caso
Authors: Silva D.F. , Carmo L.M. , Sousa A.G. , Marques N.F.S. , Oba E.
Published: October 2019

RESUMO O presente relato descreve uma condição rara de intussuscepção uterina em uma cadela sem raça definida, quatro anos de idade, diagnosticada por meio de celiotomia exploratória e análise anatomopatológica. Foi realizada ovariossalpingo-histerectomia (OSH) como tratamento. Essa patologia geralmente requer manejo cirúrgico porque o diagnóstico inicial pode ser desafiador.
To understand and analyze an organization´s culture: Theoretical and methodological choices in two decades of research in Brazil
Authors: ABREU-CRUZ Ligia , BORGES-ANDRADE Jairo Eduardo , PORTO Juliana Barreiros , VICTORINO Luiz
Published: October 2019

Abstract Despite the popularity of the organizational culture construct in the organizational psychology´s practice, it is important to scrutinize the theoretical and methodological quality standards of its principles in Brazil. The present study investigated 27 articles targeting at an organization´s culture, in 18 psychology and administration top-ranked journals, issued between 1996 and 2017. The articles were classified by their theoretical and methodological characteristics, such as type of data analysis, culture definitions, among others, to be further quantified and qualitatively reviewed. The trends were discussed in face of organizational culture´s global literature standards, and according to the characteristics of national organizational behavior literature. Special attention was recommended to the alignment between method and epistemology, as well as to a convergence towards global literature´s new developments.
The maternal interactive style in shared reading: Building a categorical evaluation system
Authors: KROEFF Chrystian da Rosa , SILVEIRA Nicole Pandolfo , KAFER Ana Paula , BANDEIRA Denise Ruschel
Published: October 2019

Abstract The way of the mother’s interaction with her child is called maternal interactive style. It has been studied in the context of shared reading. This study aimed to formulate a system of evaluation of the interactive style in shared reading through behavior categories. Categories were constructed from previous studies, and then empirically tested. Fifty-two dyads participated. The average age of the mothers was 35.70 (±6.13) years; the children’s ages varied from 22 to 76 months (Mean = 48.59; Standard Deviation = 17.88). The dyads were filmed in a shared reading interaction. The videos were then analyzed. Agreement analyses (intraclass correlation coefficient) were made between observers in order to test the categories. Most of the categories presented good or excellent agreement, indicating that they were well constructed and properly described. We believe that the system may be useful in future studies investigating the relationship of the maternal interactive style in shared reading with other variables involved.
Inovação e Difusão de Tecnologia na Agricultura de Várzea na Amazônia
Authors: Petry Jonas Fernando , Sebastião Sabrina Arcanjo , Martins Erik Garcia , Barros Paulo Berti de Azevedo
Published: October 2019

Resumo A literatura sobre a inovação e a difusão de tecnologias no agronegócio é vasta e a explicação dominante para a disseminação de inovações enfatiza o processo de influência e fluxo de informações através de um sistema social. Questões de pesquisa relativas à inovação e difusão de tecnologias ultrapassam os limites disciplinares convencionais. Este artigo tem como objetivo investigar a inovação e a difusão de tecnologias no contexto da agricultura em áreas de várzea no interior do Estado do Amazonas. Um conjunto de proposições foi desenvolvido com foco nos fatores que influenciam na concepção do processo de inovação e difusão. Através de uma pesquisa qualitativa, foram feitas entrevistas semiestruturadas. Os estágios de análise do processo mental de difusão não determinam a adoção de inovação na presente pesquisa. Os resultados sugerem que o ambiente competitivo do lado da oferta, bem como a influência das indústrias de agronegócio, assistência técnica, agenda política de desenvolvimento, projetos universitários e prática de campo podem favorecer a difusão de tecnologias. O artigo busca ampliar o atual paradigma na compreensão de inovações e na difusão, incorporando fatores operantes em um contexto peculiar de agricultura, sugerindo elementos que, se estimulados, podem ser comunicados e assimilados dentro de um sistema social.
Coprodução Sociedade Civil - Governo na Constituição de Cidades Inteligentes no Estado do Pará
Authors: Coutinho Mauro Margalho , Vasconcellos Sobrinho Mário , Oliveira Sue Anne Collares Maestri de , Santiago Ana Margarida
Published: October 2019

Resumo O artigo discute as possibilidades de constituição da concepção de cidades inteligentes no estado do Pará a partir da coprodução de serviços públicos entre sociedade civil e governo. De forma particular, apresenta-se duas abordagens de coprodução contextualizadas em um cenário de telemedicina. Uma analítica, com foco rural, apresentada por via de um estudo de caso caracterizado pela parceria entre uma organização da sociedade civil e organizações públicas de diferentes esferas do governo para viabilizar atendimento médico especializado e; outra propositiva com foco urbano, apresentado em forma survey, onde se busca identificar a viabilidade de implantação de um serviço de compartilhamento de dados para coproduzir serviços públicos, inclusive serviços de telemedicina preventiva nos bairros da Região Metropolitana de Belém. Esta coprodução se dá a partir da cessão de uma porção da rede WiFi das famílias e indivíduos em áreas onde a infraestrutura de telecomunicações dos governos municipais não se faz presente. Tem-se como questão central a pergunta: Em que medida os cidadãos e as organizações não governamentais estão dispostos em coproduzir com o governo a partir do estabelecimento de parcerias?. Demonstra-se que tantos membros da sociedade civil quanto organizações não governamentais estão dispostos a coproduzir com o governo.
Technology Perspectives and Innovative Scenarios Applied in the Amazon Region
Authors: Arruda Filho Emílio José Montero , Muylder Cristiana Fernandes De , Cançado Airton Cardoso , Dholakia Ruby Roy , Paladino Angela
Published: October 2019

Abstract This paper aims to summarize the technology perspectives and innovative scenarios applied in the Amazon region. A call for papers for the Special Issue yielded four accepted articles that serve as the source for the summary. All these articles focus on specific cases in the Legal Amazon region and provide empirical evidence supported by theories and relevant literature. All the articles emphasized the need for investment in the form of networks for development and innovation. A descriptive, qualitative approach using the bibliometric software WordStat 8® identified the words most frequently used in the four papers included this special issue. The most relevant terms identified were: network, innovation, firms, production, research and development. In total, these articles point to varied partners and institutions necessary for building networks to further development and innovation. This Special Issue is a first step to building a knowledge base focused on the Amazon region that is missing in the academic literature. Future contributions must build and expand the discussion of empirical cases and reflect different disciplines that contribute to industries, policies, society and networks. This is necessary to improve innovation and economic development of this important region.
Poéticas da migrância e ditadura: exílio e diáspora nas obras de Julián Fuks e Francisco Maciel
Authors: Fernandes Pádua
Published: October 2019

Resumo O artigo trata da questão dos exílios e das migrações, em relação à ditadura militar, em dois autores da literatura brasileira contemporânea: Julián Fuks e Francisco Maciel. O romance A resistência (Fuks, 2015) é analisado segundo os conceitos de pós-memória (Hirsch, 2008) e privatização do trauma (Seligmann-Silva, 2014). Este romance, em sua tentativa de construir a memória da família relacionada ao exílio de pais argentinos e à adoção de um filho, retrata, nas dificuldades formais de escrever o livro, os problemas políticos do processo de justiça de transição no Brasil, em comparação com a Argentina. Na obra de Francisco Maciel, a discriminação racial contra a população negra é um tema central. A repressão política considerava que o movimento negro representava ameaça contra a segurança nacional. O artigo analisa a questão das migrações dos negros na obra de Maciel em termos de diáspora (Hall, 2003), e explica como ela não se torna apenas tema, mas também forma literária, no romance Não adianta morrer (Maciel, 2018).
Effect of silicon on protein and lignin contents of two annual flower species
Authors: Traspadini Edilaine Istéfani Franklin , Mantovani Cibele , Prado Renato de Mello
Published: October 2019

Abstract The beneficial effect of silicon on plants is known, but there are no studies demonstrating the effect of this element on protein and lignin production in ornamental plants. This study aimed to assess the effects of monosilicic acid fertigation at 0, 2, 4, and 8 mmol L-1 of Si on protein and lignin production of two ornamental species: Viola x wittrockiana Gams ex Nauenb. & Buttler ‘Majestic Giants II Fire’ e Tagetes erecta L. ‘Hero’ (color mix). The experiment was installed in a 4 × 2 factorial arrangement using a completely randomized design with five replications. After 90 days of the sowing, we assessed N and Si contents in shoot system, Si accumulation in shoot system, root, and total, and lignin and protein production. An increase in lignin followed by its reduction was observed from the concentration of 2.0 (4.29) and 4.3 (5.72) mmol L-1 of Si for Viola and Tagetes species, respectively. Silicon application promoted higher lignin content in T. erecta and V. x wittrockiana.
Cuttings of Euphorbia phosphorea Mart and Euphorbia enterophora Drake at different concentrations of indole-butyric acid and analysis of economic viability
Authors: Rossa Überson Boaretto , Winckler Paulo Roberto , Winckler Filho Paulo Roberto , Westphalen Danielle Janaina , Gaspar Rozimeiry Gomes Bezerra
Published: October 2019

Abstract Defining seedling production protocols for ornamental species through the use of plant regulators requires economic analysis that demonstrates the real financial returns of such activity to horticulturists. The objective was to evaluate the influence of using indole butyric acid regulator (IBA) on rooting of Euphorbia phosphorea (Mart) and Euphorbia enterophora (Drake) cuttings, as well as to analyze the economic viability of seedling production with the use of IBA. The cuttings were 10 cm long, and treated with IBA at concentrations of 0; 1,000; 3,000; and 5,000 mg L-1. The cuttings were place in vermiculite substrate and were irrigated daily inside a greenhouse. The experimental design was completely randomized, with 4 replications, containing 5 cuttings per experimental unit. Evaluations were performed 150 days after establishing the experiments. The Net Present Value (NPV) and the Internal Return Rate (IRR) were analyzed to determine the economic viability analysis of using IBA. For E. phosphorea there was no significant difference between treatments for cuttings survival, number of roots and length of roots. Callus formation was not observed at the base of the cuttings, and the highest survival percentage was observed in T3 (3,000 mg L-1) and T4 (5,000 mg L-1) treatments. Treatment T1 (control) presented a lower number of roots per cutting (12.8) and higher average length of the three largest roots (12.56 cm). The use of the IBA regulator increased the percentage of rooted cuttings and the number of roots per cutting, and the concentration of 3,000 mg L-1 was recommended for E. phosphorea. Regarding aspects of economic viability, using IBA at the commercial nursery level is recommended. For E. enterophora, IBA is not recommended because it is an easily rooted species (95%), therefore, denotes the economic unfeasibility of its use.
Growth and quality of Brazilian pine tree seedlings as affected by container type and volume
Authors: Vieira Leandro Marcolino , Gomes Erik Nunes , Brown Theodore Aaron , Constantino Valdeci , Zanette Flavio
Published: October 2019

Abstract Araucaria angustifolia (Bert.) O. Kuntze (Araucariaceae), commonly known as araucaria and Brazilian pine tree, can be grown for their edible pine nuts (pinhões), medicinal properties, and ornamental purposes. The aim was to assess the shoot and root growth and the overall quality of A. angustifolia seedlings grown in containers with different sizes, shapes and composition. Seeds were sowed in five containers: I – 126cm3 polypropylene cone-tainers (small cone-tainers); II – 290cm3 cone-tainers (large cone-tainers); III – 879cm3 polyethylene black bags; IV- 275 cm3 nonwoven fabric (TNT) containers (small TNT container) and; 493 cm3 nonwoven fabric (TNT) containers (large TNT container). Seedlings were evaluated 210 days after sowing, regarding the following variables: aboveground height (cm), root collar diameter (mm), shoot dry mass (g), roots dry mass (g), total dry mass (g), leaf area (cm2), roots area (cm2), roots volume (cm3), sturdiness quotient, root-shoot ratio and Dickson quality index. Height was superior for seedlings grown in the plastic bags (27.6 cm) and the large TNT containers (27.02 cm) when compared to the small and large cone-tainers (21.75 and 21.78 cm, respectively). Plastic bags also presented greater values of root-collar diameter, shoots, roots and total biomass and Dickson Quality index. Small and large TNT containers promoted lower root area and volume when compared to large polyethylene cone-tainers, but allowed for the same or better aboveground growth. Taking all results analyzed together, the polyethylene black bag promoted better growth and quality of Brazilian pine tree seedlings in comparison to the other containers.
Reflexões sobre o impacto da política pública do PNAIC na formação continuada das professoras alfabetizadoras de Lages-SC
Authors: Schneider Neusa Maria Arndt Weinrich Araujo , Grosch Maria Selma , Dresch Jaime Farias
Published: October 2019

Resumo A formação continuada das professoras alfabetizadoras da rede municipal de educação de Lages-SC, através da política pública do Pacto Nacional pela Alfabetização na Idade Certa (PNAIC), é o objeto de análise neste artigo. O objetivo geral foi investigar o impacto do PNAIC na formação continuada das professoras alfabetizadoras da rede municipal de educação de Lages, buscando evidências da contribuição efetiva do PNAIC na sua formação. Os objetivos específicos foram: identificar qual a concepção de ensino-aprendizagem que as professoras alfabetizadoras construíram a partir da formação continuada do PNAIC; verificar se a concepção das professoras alfabetizadoras está voltada para a alfabetização na perspectiva do letramento; e analisar se o PNAIC contribuiu para a prática pedagógica. Participaram da pesquisa dez professoras alfabetizadoras. A pesquisa demonstrou que a formação continuada, apesar de proporcionar momentos de estudo teórico e prático, não chegou a provocar mudanças conceituais significativas.
Association of Age with Efficacy of Immunotherapy in Metastatic Melanoma
Authors: Jain Varsha , Hwang Wei-Ting , Venigalla Sriram , Nead Kevin T. , Lukens John N. , Mitchell Tara C. , Shabason Jacob E.
Published: October 2019

Management of melanoma has been revolutionized by the use of immune checkpoint inhibitors. Immune system changes associated with aging may affect the efficacy of immune-based therapies. Using the National Cancer Database, we evaluated the impact of age on the receipt and efficacy of modern immunotherapies in patients with metastatic melanoma. We identified 11,944 patients from 2011–2015, of whom 25% received immunotherapy. Older (≥60 years), compared with younger, patients were less likely to receive immunotherapy (odds ratio, 0.69; 95% confidence interval [CI], 0.61–0.78; p < .001). Immunotherapy was associated with a survival benefit in both younger and older patients (<60 years: hazard ratio [HR], 0.64; 95% CI, 0.57–0.72; p < .001; ≥60 years: HR, 0.55; 95% CI, 0.50–0.60; p < .001). Importantly, there was a statistically significant interaction between age and survival with immunotherapy, where a greater benefit was observed for older patients (pinteraction = 0.013). Further work studying the age-related response to immunotherapy is warranted.
Production of porous permeable ceramics based on silicon carbide for filtration of hot flue gases (the review)
Authors: Krasnyi B. L. , Ikonnikov K. I. , Vartanyan M. A. , Rodimov O. I.
Published: October 2019

The article presents an analytical review of the literature on oxide ceramic binder, which are used to obtain porous silicon carbide materials. The most promising ceramic binders are determined and the properties of materials based on the data of ceramic binders are given. The mechanisms of action of modifiers that reduce the heat treatment temperature to 100 ºС are considered. Ill. 3. Ref. 48.
Unshaped diatomite based heat insulating material for aluminum alloys
Authors: Kashcheev I. D. , Glyzina A. E. , Finkelstein A. B. , Scheffer A. A. , Ishtuganov I. R. , Pavlova I. A.
Published: October 2019

The results of the study of diatomites of the Ilinsky field (Sverdlovsk region) for the manufacture of unshaped insulation materials and their use as insulating materials in crucibles with aluminum melt are presented. The use of diatomite as a heat insulating material reduces the power consumption during the exposure of the aluminum melt in the crucible resistance furnace, prevents the appearance of hydrogen porosity and does not lead to saturation of the melt with silicon. Ill. 4. Ref. 7. Tab. 2.
Non-fire clay heat insulation from self-sealing masses based on burnable additives of plant origin. Part 1. The choice of burnable additives of plant origin for self-consolidation of masses in a hydraulically closed volume
Authors: Sokov V. N.
Published: October 2019

It is proposed to modify the method of obtaining self-compacting masses by changing the nature of the compacting component ― from expensive and environmentally unsafe polystyrene to a burnable plantbased additive that can self-absorb shrinkage moisture from the molding material enclosed in a hydraulically closed volume. At the same time, part of the mixing water under pressure penetrates into the clay particles with pre-modified physicochemical properties of the surface, forming a semi-permeable shell. Ill. 3. Ref. 3.
XVII International conference of refractorists and metallurgists (16‒17 may 2019)
Authors: Gavrik G. G.
Published: October 2019

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TotalSeq™-A Antibodies and Cell Hashing with 10x Single Cell 3' Reagent Kit v3 3.1 Protocol v1
Authors: Li Sam
Published: October 2019

Buyer is solely responsible for determining whether Buyer has all intellectual property rights that are necessary for Buyer's intended uses of the BioLegend TotalSeq™ products. For example, for any technology platform Buyer uses with TotalSeq™, it is Buyer's sole responsibility to determine whether it has all necessary third party intellectual property rights to use that platform and TotalSeq™ with that platform.TotalSeq™-B antibodies are designed to be used with 10x Single Cell 3’ Reagent Kit v3 with Feature Barcoding. The adjusted protocol below is for customers who are utilizing TotalSeq™-A antibodies with the v3 kit instead. Note: Step 4 from the 10x Genomics user guide document number CG000185, Rev B only applies to the cDNA library and NOT to the TotalSeq™-A library.Please read the entire protocol below and the 10x Genomics user guide for the Chromium Single Cell 3ʹ Reagent Kits v3 with Feature Barcoding technology for Cell Surface Protein before starting the experiments. 10x Genomics user guide document number CG000185,Rev B.Commonly used abbreviations: ADT: Antibody derived tags, the oligo sequence conjugated to regular TotalSeq™-A antibodies HTO: Hashtag oligonucleotides, the oligo sequence conjugated to TotalSeq™-A Hashtag antibodies
Click histochemistry for whole-mount staining of brain structures v1
Authors: Lazutkin Alexander
Published: October 2019

Labeling of the replicating DNA with synthetic thymidine analogs is commonly used for marking the dividing cells. However, until now this method has only been applied to histological sections. A growing number of current approaches for three-dimensional visualization of large tissue samples requires detection of dividing cells within whole organs. Here we describe a method for labeling dividing cells with 5-ethynyl-2'-deoxyuridine (EdU) and their further detection in whole brain structures (for example, hippocampus) using the Cu (I) -catalyzed [3+2] cycloaddition reaction (so-called click-reaction). The presented method can be used for brain neurogenesis studies as well as for whole-mount staining of any preparations in which the terminal ethynyl group has been introduced. • New click histochemistry method based on Cu (I) -catalyzed [3+2] cycloaddition reaction allows whole-mount staining of brain structures and other tissues. • Our whole-mount click histochemistry method allows to visualize dividing cells in 3D and can be used in neurogenesis studies, i.e. for birthdating dividing early progenitors and further tracking of proliferation, survival, migration, differentiation, and fate of their progeny. • Our whole-mount click histochemistry staining demonstrates high staining specificity, high signal intensity, and low background levels in young and adult mouse brain tissue.
meta analysis v1
Authors: Wan Chuandan
Published: October 2019

A systematic literature search was performed using PubMed, Embase, and WANFANG MED ONLINE databases up to March 18, 2019. All literature was analyzed using Meta Disc 1.4 and STATA 14.0 software. Diagnostic measures of accuracy of ctDNA in cervical cancer were pooled and investigated. Fifteenstudies comprising 1109 patients with cervical cancer met our inclusion criteria and were subjected to analysis.
Minimal sample metadata for healthy colon tissue v1
Authors: Teytelman Lenny
Published: October 2019

This is just a draft. Please feel free to revise and comment, but try to keep the total fields to a maximum of 20.
Chondrocyte isolation from human cartilage v1
Authors: Snelling Sarah
Published: October 2019

A standard methodology used within our group for extracting chondrocytes from human cartilage obtained as waste tissue at the time of joint replacement. Chondrocytes obtained through this method are used at P1 (at most P2) for in vitro assays. This is adapted from other published methods based on the requirements of our group for a consistent and straightforward method for obtaining viable cells.
The Effect of Hidden Neurons in Single-Hidden Layer Feedforward Neural Networks
Authors: SEVİNÇ Ender
Published: October 2019

Especially in the last decade, Artificial Intelligence is gaining popularity increasingly since deep learning and neural networks have fast and powerful machine learning-based techniques that can solve many real-time problems efficiently. In this study, Extreme Learning Machine (ELM), capable of high and fast learning is used for optimization parameters of Single hidden Layer Feedforward Neural networks (SLFN)s. The learning capability of such systems is directly related to the effectiveness of the parameters and the calculation methods. Hidden neurons number, one of the parameters in the calculations is discussed and its role is examined. The importance of the appropriate selection of this value will not only be emphasized but also a new method will be proposed for proper selection. The proposed method, Normalized Average Value (NAV) is a simple and effective formulation that originates from statistical methods in this field. Experimental results for determining a correct number of hidden neurons (L) show that random selection of this number causes either overfitting or under fitting problems. NAV can improve any algorithm in order to reach better learning rates. The results show that it provides a 10-15% performance increase due to random selection if the number of hidden neurons, L is determined according to the result of the study.
İşletme ve Çalışan Özellikleri Açısından Bulut Bilişim Algısı Farklılaşır Mı?
Authors: CENGİZ Esra , BAKIRTAŞ Hülya
Published: October 2019

Bu çalışmanın amacı, bulut bilişim teknolojisi kullanan işletme ve çalışanlarının sahip oldukları özelliklerin bulut bilişime ilişkin algı, davranışsal niyet ve bulut bilişim kullanım açısından farklılık gösterip göstermediğini incelemektir. Araştırmanın verileri, Haziran 2017-Mayıs 2018 tarihleri arasında anket tekniği kullanılarak toplanmıştır. Tüm değerlendirmeler 411 anket üzerinden yapılmıştır. Analiz bulgularına göre, çalışanların bulut bilişime ilişkin davranışsal niyeti, bulut bilişim eğitimi alıp almama ve çalışanların yaşları açısından farklılaşmamakla birlikte, algıladıkları faydanın bulut eğitimi alıp almama, bulut bilişim deneyimi ve ortalama bulut bilişim kullanma açısından farklılaştığı görülmektedir. Çalışanların bulut bilişim kullanım kolaylığı algısının ise bulut bilişim eğitimi alıp almama ve ortalama bulut bilişim kullanma süresi açısından anlamlı bir farklılık gösterdiği bulgusuna ulaşılmıştır. Bulut bilişim kullanım davranışı, bulut eğitimi ve bulut deneyimine göre anlamlı bir şekilde farklılaşmaktadır. İşletmelerin çalışan sayısı, kuruluş yılı, sektörü ve sermaye yapısına göre, bulut bilişime ilişkin algıladıkları fayda ve bulut bilişimi kullanma davranışının farklılaştığı bulgusuna ulaşılmıştır. Sadece çalışan sayısı açısından bulut bilişime ilişkin kullanım kolaylığı algısı istatistiksel olarak anlamlı değildir. Ayrıca işletmelerin sermaye yapısına göre bulut bilişime ilişkin davranışsal niyetinin de farklılaşmadığı bulgusuna ulaşılmıştır.
Long‐Term Earthquake Hazard in North China Estimated from a Modern Catalog
Authors: Xiong Ziyao , Zhuang Jiancang , Zhou Shiyong
Published: October 2019

In this study, to obtain optimal estimates of the earthquake hazard in North China based on the modern earthquake catalog, we used two variable kernel function estimation methods, proposed by Stock and Smith, and Zhuang, the Bayesian Delaunay tessellation smoothing method by Ogata (ODTB), and a newly proposed incomplete centroidal Voronoi tessellation (ICVT) method, to calculate the total and background seismic spatial occurrence rates for the study area. The sophisticated ODTB method is more stable than the others, but is relatively expensive, in terms of computation demands, whereas Zhuang et al.’s kernel estimate and the new ICVT method are able to provide reasonable estimates and easier to implement. We also calculated the spatial variations of the b‐value, using the Bayesian method with smoothness prior proposed by Ogata. Using comparative analyses and simulation experiments, we show that all of the methods give similar spatial patterns of seismic occurrences.
The Clinical Problem: Heart Failure Syndromes and their Epidemiology
Authors: Kaluzna-Oleksy Marta , Jankowska Ewa
Published: October 2019

Heart failure (HF) is increasing in incidence and is a growing health care burden. HF is responsible for a large proportion of deaths as well as for diverse associated morbidities. Both in-hospital and 1-year outcomes of patients admitted for acute HF (AHF) remain poor. HF can be classified by LVEF, by the time course of its presentation and by its associated symptoms and triggering factors. The population of patients with HF is huge, and prognosis remains poor.
Combined RAAS and NEP Inhibition
Authors: Vergaro Giuseppe , Metra Marco
Published: October 2019

The neurohormonal model of HF has provided the rationale for the use of drug classes blocking the effectors of both the RAAS and SNS at different sites, including angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), mineralocorticoid receptor antagonists (MRA), and beta-blockers. Combined NEP and ACE blockade although unsuccessful with omapatrilat in the OVERTURE trial, found success with sacubitril/valsartan in the Paradigm-HF trial. The results of PARADIGM-HF trial represent one of the most significant breakthroughs in the management of HF of the last decade, representing a shift from neurohomonal antagonism to neurohormonal modulation.
Beta-3 Receptor Agonists
Authors: Bachus Erasmus , Ponikowski Piotr
Published: October 2019

Beta-3 adrenergic receptors (β3-AR) have a more widespread tissue distribution in the human body as compared to beta1- and beta2 (β1/2)-adrenergic receptors, including in the bladder, brain, adipose tissue and cardiovascular system. Thus, β3- AR are potential drug targets for a wide range of therapeutic areas, both cardiovascular and non-cardiovascular including overactive bladder (OAB), depression, metabolic syndrome, obesity and heart failure (HF).  β3-AR agonists that are selective to the β3-AR include CL 316,243, amibegron (SR58611A), mirabegron (YM-178) and vibegron (RVT-901). However, in HF, study results regarding a possible inotropic effect of β3-AR agonists remain equivocal and some authors report a negative inotropic effect in HF and β3-AR antagonists are also under study.
Potassium Binders
Authors: Tycinska Agnieszka , Jankowska Ewa
Published: October 2019

No abstract
Iron Therapy
Authors: Jankowska Ewa , Drozd Marcin , Tkaczyszyn Michał , Ponikowski Piotr
Published: October 2019

No abstract
Prácticas Artísticas Colaborativas: nuevos formatos entre el arte y la educación
Authors: Sola Pizarro Belén María
Published: October 2019

Este artículo pretende aportar una reflexión sobre las prácticas artísticas realizadas en colectivo a partir de la observación del proceso de trabajo del grupo de creación audiovisual “La rara troupe”. El lugar desde el que se genera la investigación es el Departamento de educación y acción cultural del MUSAC, Museo de Arte Contemporáneo de Castilla y León y es por ello que además, la hipótesis de trabajo examina estos nuevos espacios institucionales como potenciales dispositivos que,  emancipados de la exposición, se muestran propicios para la generación de prácticas artísticas que continúan una genealogía de trabajo dentro de las artes que se han dado en llamar contextuales o colaborativas.
Hacia una espacialidad queer. Geografías de la sexualidad en la obra de Cabello/Carceller
Authors: Jimenez Leciñena Javier
Published: October 2019

Las minorías sexuales se han visto relegadas a los márgenes del espacio público debido a una configuración exclusiva del mismo como masculino, patriarcal y heteronormativo. Así, se formaron unos circuitos de espacios destinados a la sociabilidad gay que se contraponían a los hegemónicos y que posibilitaban una existencia más o menos pacífica y encubierta. Con el surgimiento de la Teoría Queer en los años 90, estos espacios, que siempre habían sido considerados lugares de libertad y de empoderamiento, fueron analizados de manera critica y se empezó a hablar de maneras distintas de habitar el espacio, investido de atributos como la fluidez y la transitoriedad, sentando las bases de un “espacio queer”. De esta manera, el trabajo pretende explorar teóricamente qué es el espacio queer, y su plasmación a través de la obra de Cabello/Carceller, cuyos trabajos plantean esta critica hacia estos espacios asimilados por la cultura gay y que han contribuido a una fuerte identidad de grupo que hoy en día se tornaría ineficaz para una lucha activa contra las estructuras heteronormativas.
Selection of the Method and Analysis of the Results of the Application of Minimally Invasive Methods of Treatment of Hydatidous Liver Echinococcosis
Authors: Panfilov Konstantin Arkad'evich , Ivanov Sergey Anatol'evich , Korymasov Evgeniy Anatol'evich , Bogdanov Vladimir Evgen'evich
Published: October 2019

Objective. To analyze minimally invasive treatment methods (puncture-draining intervention and laparoscopic) of liver echinococcosis and to develop an optimal treatment algorithm.Methods. The results of 120 clinical observations of patients with liver echinococcosis who were treated from 2002 to 2018 are presented. based on SOKB them. V.D. Seredavina (Samara). The comparison group (n = 68) consisted of patients with PDV and laparoscopic intervention in the period from 2002 to 2008, the main group (n = 52) - patients with PDV and laparoscopic intervention in the period from 2009 to 2018.Results. The starting points of the choice of treatment for echinococcosis in patients of the main group were the stage of life and the diameter of the hydatid cyst. Evaluation of the results of surgical treatment was carried out on the basis of a list of criteria that were assigned the values ​​of "good", "satisfactory", "unsatisfactory". With the right choice of surgical treatment tactics, as well as the priority of echinococcectomy in patients of the main group, 94% of clinical observations (n ​​= 52) achieved positive results.Conclusion. The proposed differential algorithm of surgical tactics of echinococcosis using minimally invasive techniques answers questions regarding the choice of access and method of surgical treatment based on the size of cysts, their number and localization, as well as the period of the parasite's vital activity.