bluuebunny/crossref_metadata_2025 huggingface dataset:
Results of construction of correlation fields with trend lines and determination of direction of relationships between studied indicators
Authors: Sirman Y. , Preys N. , Savytskyi I.
Published: September 2022

The aim of work is construction of correlation fields with trend lines and determination of the directionality of relationships between the investigated indicators of endothelial dysfunction, hypoxia and oxidative stress.

Our results indicate that Willebrand factor, endothelin-1, 2,3-diphosphoglycerate, MDA, diene conjugates and eNOS are informative markers in the pathogenesis of experimental diabetic retinopathy. As a result of the research, it was established that there is a direct linear relationship between the Willebrand factor indicator and malondialdehyde, since the points of the correlation field are practically located on a straight line. We trace a similar type of direct linear relationship between Willebrand factor and diene conjugates. The specified results confirm the mutually aggravating relationship between the development of endothelial dysfunction and oxidative stress. We trace an inverse linear relationship between Willebrand factor and peroxidase. With an increase in Willebrand factor indicators by stages, we trace a decrease in peroxidase indicators, which indicates a relationship between endothelial dysfunction and a weakening of antioxidant protection. As a result of the study, it was established that the first two indicators: malondialdehyde and diene conjugates have an almost direct linear relationship with endothelin-1 indicators. These results confirm the relationship between the functional and structural state of the endothelium and the development of oxidative stress. It was established that the peroxidase indicator has an inverse linear relationship with the endothelin-1 indicators, which, as in the case of the Willebrand factor, indicates a violation of antioxidant protection in the event of endothelial dysfunction. As a result of the analysis of the dependence of the indicators of 2,3 diphosphoglycerate, Willebrand factor and eNOS, it was found that in the first two pairs of indicators, there is an inverse linear relationship between the indicators. As eNOS levels increase by stage, levels of 2,3 diphosphoglycerate and Willebrand factor decrease. In the case of an inverse relationship between the parameters of the Willebrand factor and eNOS, a practically functional connection is observed, since the coefficient of determination is almost 1. The obtained results indicate that the violation of the structural and functional state of the endothelium and the development of hypoxia are interconnected with the violation of the physiological pathway of oxide synthesis nitrogen. The relationship between the indicators of 2,3 diphosphoglycerate and the Willebrand factor was revealed, which has a direct relationship between the variables, which once again confirms the aggravating interaction between hypoxia and endothelial dysfunction.
Dynamics of endogenous intoxication in experimental diabetes mellitus
Authors: Zaiats Liubomyr , Fedorchenko Yuliya , Zukow Walery
Published: September 2022

Background. Nowadays, diabetes mellitus is defined as one of the global medical and social problems and shows a growing tendency. The purpose of the study was to analyze the dynamics of endogenous intoxication in experimental diabetes mellitus. Materials and methods. The experiments were performed on 88 white male Wistar rats weighing 170-210 g. Animals were divided into three groups: 1 - intact; 2 - control; 3 - experimental with a model of diabetes mellitus, which was reproduced by intraperitoneal injection of streptozotocin by “Sigma" company (USA), diluted in 0.1 M citrate buffer with a pH of 4.5, at a rate of 60 mg/kg body weight. The control group of animals received an intraperitoneal injection with an equivalent dose of 0.1 M citrate buffer solution with a pH of 4.5.

All studies were performed under thiopental-sodium anesthesia at a rate of 60 mg/kg body weight. To determine endogenous intoxication, blood sampling of middle mass molecules (MMM) was performed 14, 28, 42 and 70 days after the streptozotocin injection. Detection of MMM fractions was performed by spectrophotometer «SF46» at the wavelength of 254 nm (MMM254) and 280 nm (MMM280). The STATISTICA 10 program was used for statistical processing of the obtained results. Results. The conducted biochemical studies of blood serum showed that in animals with streptozotocin-induced diabetes mellitus there was an increase in the content of both MMM fractions compared to the similar indicators of the control group of animals at all stages of the experiment: in the 14 days increased by 32,9% - MMM254, by 12.7%- MMM280, in the 28 days increased by 44,3 % MMM254, by 34,0 % MMM 280, in the 42 days increased by 62,8 % MMM254, by 64,8 % MMM280, in 70 days increased by 76,1 % MMM254, by 81,1% MMM280. Conclusions. Streptozotocin-induced diabetes mellitus is accompanied by an increase in the level of endogenous intoxication which is manifested by an increase of both MMM fractions content in serum.

The severity of endogenous intoxication depends on the duration of the endogenous factor.
Dignidad. Política y Performatividad de la Ciudad en Disputa.
Authors: Andrade Blanco Pablo
Published: September 2022

Este artículo aborda las problemáticas de la transformación de la ciudad de Santiago en contextos de la revuelta social en octubre del 2019. Para ello, se han definido líneas teóricas que visualizan a la ciudad como un escenario en el que desembocan diversos universos simbólicos de sus habitantes y que son exacerbados en contextos de crisis a través de procesos de intervención performáticas que son manifestados por individuos y colectivos en procesos de movilización política. El enfoque definido para este artículo está condicionado para dar respuesta a la pregunta: ¿cómo se resignifica la ciudad a partir de las acciones performáticas de individuos y colectivos en el espacio público de Santiago de Chile? Esto se realiza a través del método auto etnográfico que se centra en el proceso de sistematización de la propia experiencia de habitar la crisis. Dando cuenta de las relaciones existentes entre los diversos contextos simbólicos, referencias teóricas y observaciones de campo. En este sentido el texto propuesto da a conocer la crisis como una disputa que permite un ejercicio de deconstrucción de la trama urbana, una acción performativa decolonial que reclama un lugar en la ciudad por colectivos e individuos, que son parte de disidencias, grupos indígenas y migrantes, amalgamando un sincretismo en el ethos urbano, que nos lleva a pensar en un punto de inflexión y por qué no decirlo también, un punto partida para considerar el diseño en un mundo real en constantes disputas por legitimidad.
Urbanismo táctico: reivindicando la participación y el uso de los espacios públicos.
Authors: Hernández Araque Johana
Published: September 2022

El urbanismo táctico se presenta como una forma contrahegemónica de pensar y construir los espacios públicos de la ciudad. Emerge en un momento en el que existe una crisis de gobernanza multisistémica, que impulsa a ciudadanos, organizaciones y colectivos urbanos principalmente a buscar respuestas con celeridad a problemas en la calidad urbana que han trascendido por años y que cada día profundizan las brechas espaciales y sociales. Este trabajo indaga sobre el concepto de urbanismo táctico, su posible sustento teórico y las metodologías y herramientas que lo caracterizan; presenta de forma sucinta algunas experiencias de operaciones tácticas a nivel Latinoamérica, con el objetivo de visualizar de forma general algunas de las interpretaciones que se le ha dado en clave proyectual, identificando cualidades espaciales en común, metodologías y temáticas urbanas de abordaje, actores involucrados y herramientas de diseño. El abordaje de la microescala se conceptualiza como el lugar en el que se sustenta y alimenta la identidad y cultura barrial, donde se genera el encuentro y se construyen relaciones; se entiende que existe un vacío en las estructuras de abordaje espacial desde los planes urbanos en el que la microescala debería aparecer como punto de partida para una construcción de ciudad en red, democrática, heterogénea y de mayor escala. El urbanismo táctico se muestra como un modelo de acción en esta microescala a través de procesos que reivindican la participación, el uso del espacio público y los procesos de gestión colectiva; como una forma de diseñar para el mundo real a través de un accionar objetivo e integral.
Diseñar para la economía social. Potenciar con diseño alimentos tradicionales del norte argentino.
Authors: Fernández Laffont Luciana , Ferrero Andrés
Published: September 2022

A partir del análisis de la problemática social productiva actual en Argentina surge la iniciativa de atender las necesidades en determinadas áreas del trabajo desarrollado en la zona norte de Argentina por organizaciones populares que podrían mejorar su situación socio-productiva con resultados socialmente relevantes conectando entidades públicas y privadas en un modelo de construcción interdisciplinaria. Para ello se analizan los rasgos culturales tradicionales de grupos sociales respecto a los alimentos en relación a una producción originalmente de subsistencia que por una parte recogen sabidurías ancestrales con modalidades eco-sustentables que podrían generar saldos exportables (más allá de aquello que estos grupos consumen) mediante métodos de comercialización alternativa para que tales sistemas alimentarios sean también herramienta para el fortalecimiento del pequeño productor inscripto en una economía de baja escala y familiar existente en el país. Esos actores locales –y otros posibles nuevos que surjan– se encuentran desde el inicio marginados del sistema comercial hegemónico y requieren fortalecer y definir estratégicamente su producción para poder contar con condiciones más justas para el productor a la vez de ofrecer alternativas favorables para el consumidor. Un sistema de comercio alternativo como el que proponemos desde el diseño, representa el vector facilitador sobre el cual se trabaja este proyecto de desarrollo estratégico para dar posibilidad de hibridar un nuevo paradigma junto al concepto de alimentación y cultura. Este proyecto de desarrollo estratégico se encuentra enmarcado en los programas de investigación que se desarrollan en la Facultad de Arquitectura, Diseño y Urbanismo, Universidad de Buenos Aires, Argentina.
Ecos de octubre.
Authors: Román Juan
Published: September 2022

El escrito instala un punto de vista ético sobre las construcciones que realizan los estudiantes de la Escuela de Arquitectura de la Universidad de Talca en Chile como trabajo de final de carrera para obtener su título de arquitecto. Dicho punto de vista surge de los reclamos sociales que tuvieron lugar en Chile de octubre de 2019 en adelante. Puntualmente la consigna Hasta que la dignidad se haga costumbre lleva a revisar el quehacer de la escuela en cuanto aporte o no a la dignidad de las personas.
Managing Liquidity
Authors: Zeng Zhixiong , Jin Yi
Published: September 2022

This paper studies how liquidity management affects asset markets and aggregate economic performance. We explore the connection between liquidity allocation and capital allocation. The policy that changes the liquidity premia on assets has broad implications for private-sector behavior and market efficiency. Liquidity tightening, that is, a reduction in the aggregate quantity of liquid debt, is associated with credit loosening, that is, an increase in funds raised through the issuance of private liquid debt. A positive liquidity premium on debt is required for capital-allocation efficiency, while a zero-liquidity premium is required for liquidity-allocation efficiency. The optimal policy balances these two considerations. Government purchase of private debt is needed to support low interest rates. The analysis is extended to incorporate the liquidity differential between public and private debt and partially liquid capital.

This paper was accepted by Lukas Schmid, finance.

Funding: This work was supported by the National Natural Science Foundation of China [Grant 71973058].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4559 .
The Influencing Factor of Motivation to Transfer, Work Value, Social Responsibility on Nursing Intention for Patients with Emerging Communicable Diseases among Nursing Students
Authors: Park Da-Hye , Park Wanju
Published: September 2022

Purpose: This study investigated the influencing factors of motivation to transfer, job value, and social responsibility on the nursing intention for emerging communicable diseases among nursing students.Methods: Data were collected from January 1-7, 2022 through structured online surveys. The subjects were 140 students in the 3rd or 4th year of nursing college with clinical practice experience. Data were analyzed through descriptive statistics, independent t-test, Pearson's correlation coefficient and multiple regression analysis of hierarchical selection methods analysis using the SPSS statistics program.Results: In the last two-step hierarchical regression analysis, the factors influencing nursing intention for emerging communicable diseases were the attitude of social responsibility (β=.33, p=.001) and intrinsic work value (β=.25, p=.013), with 34% explanatory power of the regression model.Conclusion: Results show that the attitude of social responsibility as well as intrinsic work value are key factors that can increase nursing intention for emerging communicable diseases. Thus, it is necessary to expand research on nursing education contents, and to develop programs that strengthen the attitude of social responsibility as well as intrinsic work value.
Çocuklarda, Ergenlerde ve Genç Yetişkinlerde Transtorasik Ekokardiyografi ve Floroskopi Kılavuzluğunda Cihazla Transkateter Atriyal Septal Defekt Kapatılması
Authors: KAVURT Ahmet Vedat , TORUN Emine Gulsah , KİLİC Ayben , BAĞRUL Denizhan , GÜRSU Alper , ECE İbrahim , ÇETİN İbrahim İlker
Published: September 2022

Objective: The aim of this study was to evaluate the safety and efficacy of transcatheter atrial septal defect (ASD) closure guided by fluoroscopy and transthoracic echocardiography (TTE) and to present our experiences. Material and Methods: In this study, we evaluated 108 patients’ files taken to the catheter laboratory for transcatheter ASD closure retrospectively. The procedure was abandoned in ten patients because of septum device disproportion (6) and deficient rims (4), mainly inferior vena cava rim.
Results: Transcatheter ASD closure guided by TTE was performed in 98 patients (59 female). The mean age of patients was 9.5±6 years (2.6-46), and the mean weight was 30.3±15.3kg (12-80). TTE-guided ASD closure was successfully performed in 92 of 98 (94%) patients. The median largest ASD diameter measured by TTE was 10.75 mm (interquartile range (IQR) 9.12-14. The median stretched balloon diameter measured by fluoroscopy was 14 mm (IQR 12.4-18). The median device waist diameter was 14 mm (IQR 13-18), the median device left atrial (LA) disk diameter was 28 mm (IQR 26-31), and the median ratio of LA disc diameter to total septal diameter was 75% (IQR 68-81). The median fluoroscopy and procedural times were 8 minutes (IQR 5.6-13.75) and 36.5 minutes (IQR 30-49) respectively.
Conclusion: Transcatheter ASD closure guided by TTE and fluoroscopy is safe and effective in children, adolescents, and young adults.
Identifying effective paramedic leadership skills
Authors: Waller Jacob
Published: September 2022

Introduction:

Paramedics who assume leadership positions rarely receive education and training to prepare them for the change in role. This study examines the experiences and beliefs of paramedic leaders and suggests ways that practitioners looking to move into leadership positions can develop their leadership skills before assuming such a role.

Methods:

Qualitative, semistructured interviews were conducted with paramedic leaders from the different emergency medical services (EMS) models, including fire department, ambulance district, hospital and private EMS systems from urban, suburban and rural response areas to determine leadership training best practices, based on the leaders' own experiences.

Results:

Despite employer and regional variations, all the participants had similar experiences during the transition from frontline clinician to leader. Common themes included a lack of preparatory training, a struggle with moving from peer to boss, issues with learning how to communicate effectively and an ongoing need to perform direct patient care while also fulfilling the tasks of a manager. These issues were a source of considerable stress and self-doubt for many participants.

Conclusion:

Leadership training is not typically given to EMS field clinicians looking to assume leadership positions. Paramedic leaders have developed the necessary skills to succeed on their own by learning on the job, developing mentor/mentee relationships, and undergoing training and education in the form of advanced degrees. EMS agencies need to prioritise proactive and meaningful leadership development not only to retain current staff but also to support organisational succession plans.
Activities of Periostin and Inteleukin-13 among Asthma Patients in Comparison with Healthy people in Southern India
Authors: G R Sathya , Johnson Priscilla , Das Subhasis , Rajagopalan B Rajagopalan B , Rekha D Rekha D , Sekhar Lavanya , M. Manikandan M. Manikandan
Published: September 2022

Background and objectives: Asthma is a chronic inflammatory airway disease which requires biomarkers that reflect refractoriness to conventional therapy with inhalational steroids. Periostin is an extracellular matrix protein that is secreted in the airway epithelium, in response to stimulation by Interleukin -13 (IL-13). IL-13 is a cytokine that mediates airway inflammation following the Type 2 immune response. Both these biomarkers can be used to signify type 2 inflammatory response, which reflects steroid hypo-responsiveness in asthmatics. The objectives of the study were to: 1. Obtain the reference value of serum Periostin and IL-13 levels in healthy south Indian adult population 2. To compare the reference range of Periostin and IL-13 with that of the asthmatics on inhalational corticosteroids. Methodology: The study was carried out among 50 asthmatics and 50 healthy volunteers aged between 25 to 65 years. After procuring the informed consent, the Pulmonary Function test assessment was done to recruit the study subjects. The blood sample was collected for assessment of Serum Periostin and IL-13. Results: The median (IQR) baseline level of Serum Periostin among control group and in asthmatics was 13.2 (8.8-28.1) ng/ml and 16.7 (10.9-20.7) respectively. Also, the median (IQR) baseline level of Serum IL-13 among healthy individuals and among asthmatics was 42.9 (37.8-52.4) pg/ml and 73.5 (60.0-91.1) pg/ml respectively, which was statistically significant. Conclusion: The obtained baseline values of Serum IL-13 and Periostin could be of clinical utility in asthmatics. The validity of the data obtained from this study can be tested out on larger study populations.
Effect of Vildagliptin on Cognitive Deficits in an Experimental Model of Alzheimer’s Disease
Authors: Dash Devasrita , Kurady Laxminarayana Bairy , Chogtu Bharti
Published: September 2022

Introduction: Type 2 diabetes is considered a pivotal risk factor for Alzheimer’s disease (AD). Aluminium chloride induces hippocampal structural & functional abnormality and causes neurodegeneration. Our study evaluated the effects of vildagliptin on spatial memory, cholinergic activity, and neuronal survival in cornu ammonis 3 (CA3) region of hippocampus in an aluminium chloride-induced AD in male Wistar rats. Materials and method: Male Wistar rats were randomly divided into five groups. All animals except normal control were exposed to aluminium chloride (17 mg/kg/day) and group 3, 4 and 5 were simultaneously received rivastigmine (6 mg/kg/day), vildagliptin (5 mg/kg/day and 10 mg/kg/day) treatment respectively for 30 days. Assessment of spatial memory was followed by estimation of acetylcholinesterase (AChE) activity and quantification of neuronal cell count in CA3 region of hippocampus. Results: Vildagliptin improved spatial memory, decreased acetylcholinesterase levels, and improved neuronal count in CA3 region of hippocampus through multimodal approach. Conclusion: Vildagliptin treatment significantly attenuated aluminium chloride-induced cognitive deficits. It may serve as a promising candidate in the management of concomitant AD and type 2 diabetes mellitus (T2DM).
Anticancer Activity of Phyto Ligands from Carica papaya Leaves by Suppression of PI3CKA and BCL2 Proteins- An insilico Approach
Authors: Raj Priya Durai , Kumar Reddy Palagati Rohith , Thiruvanavukkarasu Palaniyandi , Rajesh Sindhu , Hari Rajeswary
Published: September 2022

The plant derived compounds possess several medicinal property including anticancer activities. In the present investigation molecular docking analysis was performed to identify a suitable antagonistic ligand from the phyto ligands of Carica pappya leaves which can inhibit the tumor progressive proteins PIK3CA, BCL 2. The molecular Docking analysis was performed using Autodock 4.2. The protein PIK3CA, BCL 2 structures were retrieved from PDB, and by GC-MS analysis the phyto molecules were identified. The ligand chemical structures were drawn using Chem sketch. The enzyme and ligand interaction were obtained as docking score using the Arguslabs server. Based on the docking score the best ligand was selected from the phyto constituents of Carica papaya ethanolic leaf extract and their inhibitory potential was analyzed in terms of their interactions with the amino acid residues present in the active site which were visualized and further confirmed by PYMOL. The standard drug Doxorubicin was also subjected to docking for comparison in the present study. Based on the docking score the phytochemicals namely Hexadecanoic acid, ethyl ester, Coumarine 3-(2,4-dinitrophenol), Androst-4-en-3-one,17-methoxy, 3-methoxime serves as the best antagonistic ligand in terms of their interaction with amino acids as well as inhibition of the particular tumour progressive proteins.
Serum Biomarkers for the Detection of Cardiac Dysfunction in Childhood Cancers Receiving Anthracycline-Based Treatment
Authors: Attina’ Giorgio , Triarico Silvia , Romano Alberto , Maurizi Palma , Mastrangelo Stefano , Ruggiero Antonio
Published: September 2022

Anthracyclines are routinely used in cancer chemotherapy in many childhood cancers. A serious adverse effect of doxorubicin chemotherapy is cardiotoxicity which may lead to congestive heart failure for long-term survivors years after treatment. Currently, echocardiography is used to control the heart function during anthracyclines therapy. B-type natriuretic peptide (BNP) and NT-proBNP as well as cardiac troponins have been proposed as clinical markers for subclinical anthracycline-induced cardiotoxicity. The BNP and pro-BNP can be easily measured in plasma and initial data indicate that the NT-proBNP could be sensitive predictor for the development of congestive heart failure.
Promising Phyto-Antioxidant Methanolic Extract from Canarium Odontophyllum Miq. (Dabai) Leaves against UVB Induced B164A5 Melanoma Cells as a Potential Skin Chemoprevention Agent
Authors: Ghazali Ahmad Rohi , Soon Chan Kam , Akbar Ali Noraisah , Basri Dayang Fredalina
Published: September 2022

The high incidence and mortality of skin cancer along with the development of chemotherapy resistance have urged researchers to look into alternative strategies to combat cancer. Chemoprevention is one of the well-researched strategies using natural products. Canarium odontophyllum Miq. (dabai) is a local seasonal fruit that is mainly found in Sarawak, Malaysia. The leaves of the fruit harbor many medicinal useful phytochemicals that provide a new insight for chemoprevention. The present research has been planned to study the chemopreventive activity of methanolic extract of C. odontophyllum Miq. leaves on UVB induced B164A5 melanoma cells through its antioxidant profiles. The extract displayed statistically significant (p<0.05) antioxidant activity by enhancing superoxide dismutase, SOD (1023.02 ± 106.74 U/mg protein) and catalase (0.12 ± 0.003 U/mg protein) activities compared to negative control. Low oxidative damage was also observed whereby the protein carbonyl and malondialdehyde levels were significantly reduced (p<0.05), 1.69 ± 0.296 nmol/mg protein and 1.181 ± 0.03 nmol/mg protein respectively. In conclusion, the extract exhibited a promising skin cancer chemoprevention activity through its significant antioxidant activities. These findings evidently pave the path for further investigations in chemoprevention strategy.
Singular and Combined Healing Activity of Aqueous Extract of Artemisia Jordanica and Achillea Fragrantissima in Rabbit’s Incision, Excision and Burn Models.
Authors: Al-Tawarah Nafe M.
Published: September 2022

Context: Treating wounds of various ailments is a large part of the public health care budget. The Artemisia jordanica (Aj) and Achillea fragrantissima (Af) plants are folk medicinal plants that are still increasingly used to treat wounds by healers. Objective: The purpose of this study was to investigate the activity and wound healing by using the singular and combined aqueous extracts of both herbs Aj and Af. Wound healing activity was followed through excision, incision, and burn wound models. Methods: Animals were divided into eight groups (n = 8), each group was divided into two sub-groups (n = 4), one for incision and the second for both excision and burn models. Groups were treated with either 5% or 10% w/w of combined or single herb(s). Betadine and petroleum gel were used as positive and negative control, respectively. Wound contraction rate, tensile strength, period of epithelization and histological transformations were used as scores to evaluate the effect of treatments on wound healing in wounds models. Results and discussion: Wound healing activity of 10% combined aqueous extracts of (Aj-Af) has shown a worthy attainment which has evidenced by inducement of tensile strength on the 22.1 ± 1.34 day of the treatment as compared with positive control on the 21.8 ± 0.73 day of the treatment. The wound contraction rate was occurred on the 17.4 ± 0.7 day of the treatment (p < 0.05) compared with positive and negative control on the 18.5 ± 0.14 and 24.5 ± 0.7 days of the treatment, respectively. Histological observation indicates that the wounds treated with 10% Aj-Af extract have showed thickening of epidermis and formation of granulation tissue with more prominent collagenation and blood vessels formation. Conclusions: Singular and combined aqueous extracts of Aj and Af exhibited good healing activities compared with negative and positive control (p < 0.05). Both singular and combined extracts induced significant healing markings; tensile strength, wound contraction rate, granulation and collagenation compared with negative and positive controls. Moreover, healing potential activity of combined extract (mainly 10%) revealed better marginal healing activity regarding single-herb use.
In Vitro Cytotoxic Action of Aesculus hippocastanum Extract Against PA 1 Human Ovarian Cell-Line
Authors: Roshni A. S. , Elizabeth Arul Amutha , Aishwarya S. Sneha , Brigida S Brigida S
Published: September 2022

Cancer is not a modern disease but has been present since the very early dawn of life in both animals and humans”. Cancer is a disease that is caused due to alteration in the genetic configuration (mutation) that occurs due to either an inherent biological failure or an externally acquired factor leading to genomic instability and oncogenesis. The sudden upsurge in the incidence of cancer throughout the world in the last two decades has been attributed to the environmental and lifestyle changes which includes smoking, pollution, consumption of processed food etc…It is one among the prominent health problem responsible for morbidity and mortality. It is basically a cell proliferative disorder, initially specific to an organ and advances to invasion and metastasis. Chemotherapy with anticancer drugs remain the standard treatment modality. But those treatment drugs are associated with numerous serious side effects. On the other hand, phytomedicine is now attracting attention due to its potential anticancer properties. These medicines can be considered as an alternative form of therapy in cancer management due to their cost effectiveness, therapeutic efficacy and minimal side effects. Aesculus hippocastanum (AH)commonly known as European horse chestnut is found all over the world. The principal purpose of the study is to explore the anticancer property of ethanolic flower root out of Aesculus hippocastanum by performing the MTT assay (cytotoxic study) against human ovarian cell line. The study was evaluated by assessing the inhibition of percentage of cell viability and it showed minimum viability of cell (53.68 ± 0.8755 %) at the higher concentration of 200µl of Aesculus hippocastanum sample solution with Methotrexate as a standard comparison drug. This has proved the cytotoxic effect of Aesculus hippocastanum on PA1 human ovarian cancer cell line
Assessment of Specific and Non-specific Autoantibodies among Newly Diagnosed Type 1 Diabetes Mellitus Sudanese Patients
Authors: Ishaq Hind Amin , Ibrahim Mariam Abbas , Ismail Amar Mohammed , Abubaker Nuha Eljaili , M Elfaki Elyasa
Published: September 2022

Background: Pathogenesis of type 1 diabetes mellitus is associated with the presence of specific autoantibodies and viral infection. Herein we aim to assess specific and nonspecific autoantibodies in newly diagnosed type 1 diabetes mellitus patients. Materials and Methods: In this case-control study 200 subjects were enrolled, classified into 100 newly diagnosed type 1 diabetes mellitus patients ages ranged from 1 to 16 years old, and 100 apparently health control age matched group. Serum anti-glutamic acid decarboxylase/tyrosine Phosphatase 2 (anti-GAD/IA2), anti-tissue transglutaminase (anti-tTG) and antinuclear antibodies were measured. Results: Of 100, 62(62%) were males, and 38(38%) were females. Anti-GAD/IA2, anti-tTG, and antinuclear antibodies were found to be significantly higher in the case than in the control group. Anti-GAD/IA2 and anti-tTG were associated with higher risk of type 1 diabetes mellitus (OR= 5.44, P= 0.000) and (OR=5.82, P= 0.009) respectively. Conclusion: Anti-GAD/IA2, anti-tTG and antinuclear antibodies are higher in type 1 diabetes mellitus patients. Moreover, anti-GAD/IA2 and anti-tTG are associated with a high risk of type 1 diabetes mellitus.
Screening of Stem Extracts of Andrographis echioides for Anti-Inflammatory, Anti-Arthritic, Anti-Microbial, and AntiCancer Activity against MCF-7 Human Breast Cancer Cell Lines
Authors: S. Bhuvaneswari S. Bhuvaneswari , Suchitra M. R. , Noor M. Beevi Farhana , R. Madhumitha R. Madhumitha , P. Gajalakshmi P. Gajalakshmi
Published: September 2022

Nowadays breast cancer in rheumatoid arthritis patients is the most controversial one. Rheumatoid arthritis is an inflammatory autoimmune disorder. RA may induce the order disease like cancer especially breast cancer in most women. Breast cancer starts when the breast cell begins to grow out of control. Inflammatory, anticancer drugs may show severe side effects. To overcome these herbal plants are used to make drastic changes in medical treatments. The main objective of this paper is assessment of Anti-inflammatory, anti-arthritic, anti-microbial and anti-cancer activity against the Michigan cancer foundation (MCF-7) human breast cancer cell line using the extracts Andrographis echioides. Anti-inflammatory and anti-arthritic activity show maximum inhibition of albumin denaturation, anti-proteinase, hypo-tonicity induced hemolysis, anti-lipoxygenase activity with standard drugs such as aspirin, diclofenac sodium and indomethacin at the concentration of 100µg/ml under in vitro condition. Thus the potential inhibition of protein (egg albumin) denaturation (85.80%) and for the human red blood cell (HRBC) membrane stabilization model 85.50% was observed at the concentration of 100µg/ml. The antioxidant and cytotoxicity activity of Andrographis echioides showed better inhibition in a dose-dependent manner against MCF-7 human breast cancer cell lines. The antimicrobial activity of Andrographis echioides showed maximum inhibition of E.coli (11mm), Enterococcus aerogenes and Staphylococcus aureus (10mm), and Candida albicans (11mm) at 100µg/ml concentration. The innovation of the present study revealed that the stem of Andrographis echioides have potential source for natural anti-arthritis, cytotoxicity, anti-microbial, antioxidant activity, anti-inflammatory and anticancer activities.
Remote Schooling During COVID-19 and Mental Soundness of Adolescents in Egypt
Authors: Mahfouz Nermine N. , A. Elabd Mona , El-Shaheed Azza Abd
Published: September 2022

Background: The social isolation imposed by the pandemic of Coronavirus disease of 2019 (COVID-19) has a probable impact on the adolescents’mental milestones that are inextricably intertwined with socio-emotional experiences. The physical school attendance is not only for academic achievement but it offers a unique opportunity for an interactive peer relationship. Independency, resilience, self confidence, abstract thinking, problem solving are few examples of the countless moral gains of school attendance. This mental wellbeing is the first line of defense in stressful conditions against anxiety and depression. Aim: To disclose the imprint of school closure as a stressor exposing adolescents to anxiety and depression. Materials and methods: One hundred twenty six adolescents were enrolled in our study. Two validated Egyptian inventories were used to screen for anxiety and depression. Sixty three candidates (group1) were assessed before school closure in comparison to another sixty three of their matched peers (group2) after school closure. Results: The scores of the physical, emotional, physiological and social aspects of anxiety were significantly different between the two groups with P-values of 0.021, 0.007, 0.031 and 0.007 respectively. In the assessment of depression, two items (self esteem and concentration ability) were mostly affected after school closure with highly significant P values of 0.015 and 0.016 respectively. Conclusions: Several risk factors influence the mental health of adolescents among which the school closure is an important one.
Haematological and Biochemical Parameters of Blood in Patients after BIOS of the Tibia using Bioinert and Biodegradable Implants based on Magnesium Alloy MA-10
Authors: Yatsun E. V. , M.L. Golovakha M.L. Golovakha , Maslennikov S. O. , L.V. Makyeyeva L.V. Makyeyeva
Published: September 2022

Nowadays, the search for new artificial materials to replace damaged tissues and organs is becoming increasingly important. Biodegradable materials occupy an honorable place among medical materials. Depending on the purpose, biodegradable implants should be gradually replaced by living tissue and function over a given period of time, as well as not have a negative impact on surrounding tissues and the body as a whole. Magnesium-based alloys are considered promising. Clinical studies of the dynamics of a number of key biochemical parameters that characterize the reactive response and regenerative processes in the body are of scientific and practical importance. The aim of the research was to study the laboratory - biochemical parameters of blood in patients after BIOS of the tibia using bioinert and biodegradable implants based on magnesium alloy MA-10 Materials and methods. 36 patients with tibial fractures were operated in the traumatology department of MNCE “CH of Emergency and Urgent Medical Aid” in Zaporizhzhia. After closed repositioning, the tibial BIOS was performed using biodegradable alloy screws. Blood sampling for biochemical and cytological studies was performed before and in 2, 4 weeks, 2 and 4 months after surgery. Biodegradable magnesium alloy MA-10 (TU U 24.4-14307794-270: 2018) certified for use in medicine. Results. The study of the total bilirubin dynamics in blood plasma showed that the maximum values of the indicator accompany the acute period of the pathological process. From the second week, slight fluctuations in α-amylase activity were detected, which is most likely due to the energetic support of the inflammatory process and the regeneration of damaged tissues. The use of magnesium alloy for the manufacture of screws showed stable enzyme activity for 4 weeks. In the group of patients who used magnesium alloy implants immediately after surgery, there was a significant (p≤0.05) increase in AST / ALT by 44%, compared with the initial value of the de Ritis coefficient, not by increasing the activity of AST, but by reducing activity ALT. The undulating dynamics of ESR, fibrinogen B and total bilirubin in the blood of patients of both groups reflects the stages of the reparative process. Conclusions. The bioinertness and expediency of using implants made of biodegradable magnesium alloy MA-10 in the dynamic BIOS for diaphyseal fractures of the tibia are substantiated.
In Vivo Assessment of Lycopene Effect on Obesity-Induced Inflammation
Authors: Kamel Samar , Zeidan Dalia W. , E. Khaled Howayda , Elhady Ali Zinab Abd- , Elrefaei Nadia G. , El-Naggar Mohamed S.
Published: September 2022

A chronic low-grade inflammation is one of etiologic conditions closely associated with obesity. The study aims to examine the effect of lycopene on obesity inflammatory conditions in rats. 20 adult male albino rats were divided into four groups (n=5) and for 30-day treatment they were divided into the control group received corn oil as a vehicle, lycopene control group received lycopene extract (10 mg/kg) daily with gavage, obese control group subjected to high fat (HF) diet and received corn oil and obese/lycopene group subjected to HF diet and daily received lycopene extract by the same dose. Bodyweight, weight of thymus and spleen, cytokines [Resistin, Interleukin-1β (IL-1β), Tumor Necrosis Factor α (TNF-α) and Interleukin-6 (IL-6)], lipid profile, and immunohistochemical assay for the Nuclear Factor kappa-B receptors (NF-κB) expression were measured and analyzed. The results revealed that the induced obesity caused a remarkable increase in bodyweight, relative weight of thymus and spleen, levels of serum cytokines, total cholesterol and triglycerides and NF-κB receptors expression, but decreased high-density lipid (HDL) level significantly. Administration of lycopene to obese rats caused a significant depletion in the levels of serum cytokines, total cholesterol (TC) and triglycerides (TG) with a significant increase in HDL level and caused no change in bodyweight, while the relative weight of the spleen and thymus was improved. Also, lycopene caused a marked decline in NF-κB receptors expression in thymus and spleen. These results supported the importance of lycopene as a beneficial carotenoid in combating obesity and companied disturbed fat index and metabolism.
Antihyperuricemia Activity of Vanilla (Vanilla planifolia Andrews) Fruits Ethanol Extract to Male Mice (Mus musculus L.)
Authors: Nurcahyani Endang , Herliani Novita , M Kanedi M Kanedi
Published: September 2022

Hyperuricemia is a disease caused by an increase in uric acid levels in the blood over the normal level. Increased uric acid levels happen because the levels of purines in the body are quite high, so that the breakdown of purines into uric acid increases. This study used dried vanilla fruit extract using 60% ethanol solvent. The test animals used were 24 mice which were divided into 6 groups namely group Kn (standard feed), group K- (induced with suspension of chicken liver), group K + (induced by suspension of chicken liver and given allopurinol 10 mg / kgBB), group treatments P1, P2, and P3 were induced by suspension of chicken liver and vanilla fruit extract with doses of 50 mg / kgBB, 100 mg / kgBB, and 200 mg / kgBB respectively. Statistical data analysis using ANOVA (Analysis of Variance) through the SPSS 15.0 program with a level of α = 5% and continued with Duncan test at the level of α = 5%. The results of this study showed that vanilla fruit extract treatment P1, P2, and P3 had potential activity of antihyperuricemia, because it can reduce blood uric acid levels in mice induced by the chicken liver. The antihyperuricemia activity of vanilla fruit extract is comparable to the standard allopurinol chemical drug in reducing blood uric acid levels in mice statistically.
Cytotoxicity, Antidiabetic and Anticancer Studies of Insulin and Curcumin-Loaded Polymeric Nanoparticles
Authors: A.Asha A.Asha , Malar G.S. Prabha Littis
Published: September 2022

Cytotoxicity measurement is needed for all drug-loaded nanoparticles. Because, if the nanoparticles have toxicity means, the drug-loaded polymeric nanoparticles cannot be used for the drug delivery. Generally cell viability is measured in the cytotoxicity measurement. In this work, the nanoparticle have synthesized from the natural polymeric material. These nanoparticles have been prepared using a nano-precipitation technique. Drugs, Insulin and Curcumin are added to these synthesized nanoparticles. This drug was coated on the surface of the nanoparticles to enhance the biocompatibility. These drug-loaded polymeric nanoparticles are used for the drug delivery. L929 cells have been to prove the cytotoxicity of these drug loaded polymeric nanoparticles by Neutral red assay method. From the cytotoxicity assay TPIG, TPCG and CCIG, CCCG nanoparticles are not cytotoxic. Insulin-loaded Tapioca/pectin and a Casein/chitosan nanoparticle were used to study the anti- diabetic assay. Curcumin-loaded Tapioca/pectin and Casein/Chitosan nanoparticle were used for Anti-cancer studies, by making use of Human Osteosarcoma cells (HOS). From these studies, the Insulin and Curcumin-loaded Tapioca/pectin and Casein/chitosan nanoparticles are not cytotoxic, and they can be used for drug delivery.
Sonographic Measurement of the Optic Nerve Sheath Diameter to Improve Detection of Elevated Intracranial Pressure
Authors: Awdallah Faten Farid , Abulnaga Islam Hassan , Michael Suzy Fawzy , Nagi Hassan Khaled , Abdallah Mohamed Hosny
Published: September 2022

Rapid recognition of elevated intracranial pressure (ICP) is essential to avoid brain stem herniation and death. Brain stem herniation is a very serious disorder in which an excess of intracranial pressure causes part of the brain to be squeezed through the foramen magnum at the base of the skull. Increased pressure on the brain stem can lead to blood pressure and breathing problems and brain death, respiratory or cardiac arrest, permanent brain damage, coma and death. The aim of this work was to evaluate the diagnostic accuracy of using Optic Nerve Sheath Diameter (ONSD) measurements to detect elevated ICP compared to computed tomography (CT) brain scanning. A prospective, observational cross-sectional study of 100 randomly selected ICU patients with suspected elevated ICP at Cairo university hospitals and cardiothoracic surgical ICU of the National Heart Institute (NHI), Cairo, Egypt. Optic nerve ultrasonography (US) was performed on all patients; CT brain scanning was chosen as the gold standard for detecting elevated ICP. Results: the cause of elevated ICP, 51.3% of patients were admitted with head trauma P-value = 0.000, clinical signs of elevated ICP, 31.3% of patients developed convulsions and 26.3% showed Cushing reflex (P=0.004 and 0.010 respectively). Besides the Glasgow Coma Scale (GCS), patients with elevated ICP had a mean GCS score of 7 and patients without elevated ICP had mean GCS of 13 (P˂0.001). Regarding ONSD, mean average ONSD was 6 in patients with elevated ICP and 3.1 in patients without elevated ICP (P˂0.01), receiver operating characteristic (ROC) curve analysis revealed that ONSD greater than 4.31 mm was significant in prediction of elevated ICP compared to CT brain scanning with 94.8% sensitivity and 90.11% specificity. Conclusion: patients’ ONSD is a simple bedside technique that can accurately diagnose of elevated ICP compared to CT brain scanning. The diagnostic accuracy of ONSD using a 4.31 mm cut-off value can diagnose of elevated ICP with 94.8% sensitivity and 90.11% specificity.
Culture, language, and multilingual education:
Authors: Failasofah Failasofah , Mukminin Amirul , Masbirorotni Masbirorotni , Abrar Mukhlash , Fajaryani Nunung , Fortunasari Fortunasari , Hidayat Marzul , Habibi Akhmad
Published: September 2022

INTRODUCTION. In a multilingual classroom, teachers play an essential role in encouraging and fostering a multilingual attitude and behavior at the school, as their actions can considerably influence their students. This study is intended to explore the teachers’ attitudes towards multilingual policy and multilingual pedagogy. Therefore, theories on language educational policy and multilingual pedagogy and practices are discussed as guidance. METHODS. The study used a survey research design, and the questionnaires were sent online to gather the data. The participants were 100 foreign language teachers who teach at high schools in an Indonesian province. They were asked to voluntarily respond to three main themes: Multilingual education knowledge, language education policy in Indonesia, and multilingual classroom practices in the questionnaire in the questionnaire. T-test and MANOVA were employed to investigate the difference between variables. RESULTS. The descriptive and inferential analyses revealed that the attitudes towards multilingual pedagogy implemented in Indonesia were almost uniform across different foreign language teachers having a positive attitude. Out of 18 statements, the high mean scores are related to the belief that learning another language could foster openness to other people’s language and culture and learning different languages can build students’ ability to use languages within a context. DISCUSSION. Taking for granted that participants have different ages, teaching experience, gender, and foreign language, there is no significant difference in their attitude towards multilingual education and practices. Most of the participants of this study believe that multilingual education contributes to some benefit for their students. Yet, the results also show that participants also view that the government has neither provided nor accommodated proper support for multilingual education.
Frameworks de Universidades Empreendedoras: Uma Revisão Sistemática
Authors: Lara Ana Claudia , Sehnem Simone
Published: September 2022

A definição de um modelo (framework) para universidade empreendedora (UE), em conjunto com a definição de elementos e características que levam à sua existência, têm sido amplamente discutidos na literatura. Este estudo visa identificar frameworks conceituais para UE prevalentes. A amostra inicial constitui-se de 181 pesquisas extraídas do banco de dados Web of Science e Scopus, a partir da seleção dos materiais realizamos uma análise de referências para identificação de estudos adicionais. Posteriormente foi realizada uma análise de conteúdo em 50 artigos, que tornou possível a identificação de doze frameworks distintos para UE desde 1998 à 2021. Entre as principais contribuições destaca-se: Reestruturação interna, inovação, internacionalização, hibridização, P&D, sustentabilidade, interação de forma globalizada com empresas, associações e instituições, metodologias ativas, pesquisa de alta intensidade, entre outros aspectos. Elementos esses que de forma conjunta elevam o patamar das instituições. Por fim, o ineditismo concentra-se na elaboração de um framework final, que sintetiza os modelos que a literatura apresenta, sendo que as abordagens teóricas em suma, seguem a teoria institucional e a teoria econômica e, implicitamente, são integrados por fatores ambientais formais e informais que influenciam positiva ou negativamente o processo de desenvolvimento da universidade em diferentes graus. com a RSL.