bluuebunny/crossref_metadata_2025 huggingface dataset:
Sensor coating based on lipid Langmuir monolayer with the glucose oxidase enzyme molecules
Authors:   Институт радиотехники и электроники им. В.А. Котельникова РАН, Горбачев Илья А. , Колесов Владимир В. ,   Институт радиотехники и электроники им. В.А. Котельникова РАН
Published: March 2024

Создано сенсорное покрытие на основе ленгмюровского монослоя фосфолипидных молекул 1,2-дипальмитоил-sn-глицеро-3-фосфоэтаноламин (DPPE) с иммобилизованными молекулами фермента глюкозооксидазы и исследованы его сенсорные свойства. Методом изотерм сжатия исследован процесс встраивания молекул фермента глюкозооксидазы в ленгмюровский монослой фосфолипидных молекул DPPE. Показано, что адсорбция молекул глюкозооксидазы оказывает расширяющее действие на ленгмюровский монослой DPPE и приводит к увеличению площади на одну молекулу с 32.5 Å2 до 49 Å2 и уменьшению модуля сжатия монослоя с 133 мН/м до 83 мН/м. Также адсорбция глюкозооксидазы приводит к увеличению коэффициента десорбции монослоя в субфазу kd с 0.5·10-3 до 1.2·10-3. Методом атомно-силовой микроскопии охарактеризована морфология пленок с иммобилизованными молекулами фермента при различном времени его адсорбции. Увеличение времени адсорбции фермента приводит к уменьшению шероховатости поверхности формируемой пленки с 3.6 нм при 5 минутах до 2.4 нм при 60 минутах. Сформированные монослои DPPE с иммобилизованными молекулами фермента были перенесены на графитовые электроды. Методами циклической вольтамперометрии и импедансометрии изучены их сенсорные свойства. Полученные покрытия обладали чувствительностью к глюкозе в растворах с концентрацией от 0 до 1 мг/мл. Наличие линейной зависимости тока через измерительную ячейку в указанном диапазоне концентраций глюкозы делает созданные пленки перспективными для использования в качестве сенсорных покрытий.
Maximum detection range of an underwater noise source using holographic processing
Authors:   Институт общей физики им. А.М. Прохорова РАН, Кузькин Венедикт М. , Переселков Сергей А. ,   Воронежский государственный университет, Грачев Владимир И. ,   Институт радиотехники и электроники им. В.А. Котельникова РАН, Рыбянец Павел В. ,   Воронежский государственный университет, Ткаченко Сергей А. ,   Воронежский государственный университет
Published: March 2024

Описано формирование голограммы шумового сигнала подводного источника на фоне распределенной помехи. Получено выражение для ширины полосы углового распределения спектральной плотности шумового сигнала на голограмме. Оценена минимальная длительность шумового сигнала, определяющая предельную дальность обнаружения шумового источника звука. Представлен алгоритм определения параметров голографической обработки, реализующей предельную дальность обнаружения. Голографическая обработка шумовых сигналов рассмотрена с применением одиночного векторно-скалярного приемника и линейных антенн.
The grid-characteristic method on chimeric meshes application to study the keel morphometric characteristics of ice ridges.
Authors:   Московский физико-технический институт, Песня Евгений А. , Муратов Михаил В. ,   Московский физико-технический институт, Фаворская Алена В. ,   Московский физико-технический институт, Кожемяченко Антон А. ,   Московский физико-технический институт
Published: March 2024

При проектировании инженерных сооружений в арктической зоне необходимо учитывать нагрузки, передаваемые конструкции сооружения, при столкновении с различными ледовыми образованиями: айсбергами, торосами, стамухами. В работе рассматривается использование сеточно-характеристического метода для моделирования прохождения упругих волн в поперечном срезе тороса с учетом его пористости в консолидированном слое и в нижней части киля. Для учета криволинейной формы пор, заполненных воздухом или водой, предложено использовать химерные (наложенные) расчетные сетки. В результате компьютерного моделирования решена прямая задача ультразвукового исследования тороса, получены поля вектора скорости в различные моменты времени, в том числе система переотражений от пор.
Quantum Dot Sensitized Solar Cells: A Promising Avenue for Next-Generation Energy Conversion
Authors: Surarapu Pavani , Ande Janaki Rama Phanendra Kumar , Varghese Aleena , Mallipeddi Suman Reddy , Goda Dileep Reddy , Yerram Sridhar Reddy , Kaluvakuri Swathi
Published: March 2024

By taking advantage of the unique qualities of colloidal quantum dots, quantum dot-sensitized solar cells (QDSSCs) provide a viable route for next-generation energy conversion while increasing the device's adaptability and light harvesting efficiency. This research aims to thoroughly examine the possibilities and difficulties associated with QDSSCs and offer information on their applications, methods for performance optimization, and policy ramifications. To assess the state-of-the-art research on QDSSCs, the technique systematically evaluates existing literature, including peer-reviewed articles, conference proceedings, and patents. Significant discoveries highlight developments in materials design, methods for fabricating devices, and potential integrations in consumer electronics, building-integrated photovoltaics, and off-grid applications. The policy implications underscore the necessity of regulatory frameworks to tackle environmental issues, set up guidelines and certification procedures, and foster global cooperation. In summary, this research highlights the importance of QDSSCs as a viable choice for sustainable energy conversion. It advocates for cooperative endeavors to surmount obstacles and expedite their integration into the renewable energy terrain.
Pacific Northwest Streamflow Data Landscape
Authors: Kaiser Kendra E.
Published: March 2024

This project was funded by the U.S. Geological Survey Northwest Climate Adaptation Science
Center to catalog the location, temporal extent and purpose of non-USGS streamflow datasets.
As part of this project, roundtable meetings convened local, state and federal agencies, and
nonprofits to explore the complexity of gathering and integrating the identified datasets and
identify issues surrounding data-sharing across organizations.

This report synthesizes discussions from each of the state roundtable discussions convened in
the spring of 2022, and highlights common challenges and needs across the region. Additional
information from organizations not able to be present at the meetings were added after one-on-one
discussions with organization members.

Information gathered through these discussions highlights the importance of streamflow data,
multitude of data purposes, the need for additional data, and support for data management
and quality assurance.
FNAC as preoperative diagnostic tool for neoplastic and non-neoplastic breast lesions with special reference to IAC standardised reporting in Coastal population - A teaching hospital experience
Authors: Savant Supriya P , Naik Vinay , Lingegowda Jyothi B
Published: March 2024

Breast cancer is steadily increasing worldwide. This study is based on application of recently proposed International Academy of cytology (IAC) Yokohama categorisation system of Breast cytology from C1 to C5. (C1-Insufficient material, C2-Benign, C3- Atypical, C4-Suspicious & C5-Malignant). We aim to categorize the breast lesions based on the above-mentioned categorization scheme (IAC, Yokohama 2016) along with histopathological correlation (wherever possible).

This was a retrospective observational study conducted from January 2018 to December 2021 in the Department of Pathology of a tertiary care hospital involving coastal population. Ethical clearance was taken from institutional reviw committee. All patients with palpable breast lumps who had undergone FNAC were included in the study. Patient details and data were collected from the case records maintained in Department of Pathology. All quantitative parameters were described through descriptive statistics. Total scores were computed for all the risk factors. Sensitivity, specificity, Positive Predictive Value, Negative Predictive Value calculated. Risk of malignancy(ROM) was calculated for each category.

A total 200 patients, with age group ranging from 17 - 67 years with breast lesions were included in the study. C1 lesions were found in 5 cases, C2 in 152 cases, C3 in 11 cases, C4 in 4 cases, and C5 in 28 cases. Cytohistological correlation obtained in 94 cases with concordance noted in 89 cases and discordance in 5 cases.

Breast FNAC cytology categorization according to IAC Yokohama system increases accuracy of diagnosis and helps clinician in appropriate patient management.
Scorpion sting among children with respect to its complications and outcome
Authors: HS Shreedhar , P Sowmyashree , H Durgappa , K A Akshatha
Published: March 2024

Scorpion sting is an acute time limiting medical emergency commonly encountered in rural villages of the country. It is a major public health problem in many tropical and sub tropical countries. India is most affected country in Asian epidemiological data.

This study was done to study the complications and outcome of scorpion sting in children.

This is a prospective observational study.

a total of 100 cases of scorpion sting selected from the patients admitted to Vijayanagar Institute of Medical Sciences, Ballari. The demographical features, clinical presentation, complications, outcome and the response to standard treatment protocol were observed and analysed.

Scorpion sting is a common and major health problem in our area. Most commonly affected age group was 4-6 years (27%), and male children (67%) were most commonly affected. These cases were most commonly seen during March (15%) to May (14%) months. Pain at the site of sting (99%) and excessive sweating (92%) were most common presenting complaints, cold extremities (88%), tachycardia (84%), and restlessness (72%) were most common signs noted. Most common complication was myocarditis (15%), followed by pulmonary edema (7%) and encephalopathy (2%). About 98% of cases recovered without sequelae and 2% of cases died due to complications.

Scorpion sting is a serious, potentially fatal emergency in our area. Cardiovascular manifestations are most common and are life threatening complication. Administration of prazosin as early as possible is the single most effective intervention to prevent complications and mortality
Prevalence of visual impairment in patients sustaining proximal hip fracture after a simple fall
Authors: Panda Sambit Kumar , Jena Laxmidhar , Panda Jitendra Kumar , Nath Sandhyarani , Patra Gopabandhu
Published: March 2024

According to epidemiological studies, the 30% of aged 75 years and older is having impaired vision and most of the cases these patients are not in contact of the hospital care staff and community eye services. The visual assessment of older people is essential and helps to minimize the issues related to fall that led to critical problem. The proper vision is required for regain independence and improve the patient’s overall wellbeing. This kind of situation is leading the individual to unintentional injury which is higher among the visually impaired people compared to fully sighted population. Moreover, there are two major reasons for visual impairment that are more susceptible.

The study aims to analyze the prevalence of visual impairment in patients sustaining proximal hip fracture after a simple fall at SCB Medical College and Hospital, Cuttack, Odisha.

The current study has been conducted at SCB Medical College and Hospital, Cuttack, Odisha. All inpatients of the orthopaedic rehabilitation wards were recuperating from the surgical repair of a fractured neck of femur aged 75 years and above. and all the visual impairment assessed at Ophthalmology OPD. Moreover, the investigator has also invited the patients who sustained their fracture after a simple slip, trip and fall. Apart from this, the mental test of these participants was also done to analyze the ability. In this test the score of seven and above was considered for allowing the patients to take part in the study. There was a full ocular examination of anterior and posterior segment performed by the ophthalmologist using the slit-lamp bio microscope and indirect ophthalmoscope.

Visual impairment of criteria 1 sensitivity was 93% and specificity was 91%. Moreover, the likelihood ratio of positive results was 11 and negative result was 0.05. For the criteria 2 the sensitivity was 97% and specificity was 86%. Moreover, the likelihood of positive results was 6 and negative result was 0.02. Apart from this detection of potentially remedial visual impairment sensitivity was 69% and specificity was 91%. The likelihood ratio of positive result was 8 and negative result was 0.2.

The vision test and proper ocular examination were underestimated the extent of vision impairment in older adults. As per the outcome of the study, the visual impairment is common in elderly patients with a history of falls. Moreover, the study has suggested that to measure the visual acuity of all elderly patients recuperating from a proximal hip fracture after a simple fall.
Epidemiology and factors associated with amoebic liver abscess at a tertiary care hospital in Northern India
Authors: Poddar Devadatta , Chauhan Rohit , Lohchab Prateek
Published: March 2024

Liver abscess is a collection of purulent material in the liver most commonly seen in the tropical countries. It can sometimes lead to significant morbidity and mortality if not treated timely and adequately. Through this study we wish to put light upon the current status of clinical aspects, laboratory features, and outcomes of liver abscess.

The study was conducted at a tertiary care hospital in Northern India in the period of August 2020 to July 2021. All patients diagnosed with liver abscess of size >5 cm or left lobe liver abscess of any size were included in the study. All relevant laboratory investigations were conducted. The outcomes were noted and data was entered in MS Excel sheet. Analysis was done using SPSS version 26.

Sixty-three patients were included in the study. A male predominance was noted. Mean age at presentation was 37.8 years. Most patients were part of the lower socioeconomic class. Pain abdomen and fever were the most common presenting symptoms. Amoebic liver abscess was much more frequently seen than pyogenic liver abscess. Deranged coagulation profile was seen in 88.9% patients. 85.7% patients were amenable to treatment with minimal intervention. Mortality as an outcome was seen in 9.5% patients

Significant correlation was found between various laboratory parameters and outcomes such as length of hospital stay and mortality. Early diagnosis and treatment is crucial in management of patients with liver abscess even today.
Study of serum ferritin levels in preterm labour and its perinatal outcome in tertiary care centre
Authors: Kiranmai T. Pavani , Munagavalasa Sharada , Bhargavi K , Sujatha P , Sangeetha CH
Published: March 2024

Pregnant women at risk of preterm birth may be easily identified and sent to tertiary care centres for further therapy. Numerous biomarkers are being investigated for their ability to predict preterm labour; serum ferritin is one of these indicators. It is an intracellular protein that has a role in iron storage and is also an acute phase reactant that is increased during acute and chronic infections.

To evaluate serum ferritin levels in preterm labour and perinatal outcome in a tertiary care centre during 2 years.

A case control study was conducted in collaboration with the Department of Obstetrics and Gynecology at Osmania Medical College, Hyderabad, from 2019 to 2022. After receiving permission, one hundred participants with an average age of 25 years who visit Niloufer hospital are included in the research and separated into case (Group 1) and control (Group 2) groups. Group 1 consists of women who had spontaneous preterm labour, whereas Group 2 consists of pregnant women of the same gestational age who are considered controls.

Among 50 instances of preterm labour, 39 (78.0 percent) were classified as preterm (32 to 36 weeks), whereas 11 (22.0 percent) were classified as very preterm (28 to 32 weeks). The majority of the 50 patients included in the research, 31 (62.0 percent), were born by normal vaginal delivery, while 19 (38.0 percent) were delivered using emergency LSCS. CRP was positive in two patients (4.0 percent). The mean WBC levels in cases were much greater than those in controls, and the difference is statistically significant. Serum ferritin levels were 40.298 19.64 in cases and 20.343 6.82 in controls. Serum ferritin levels were substantially higher in cases than in controls on average. The mean WBC levels were greatest in extremely preterm infants, followed by preterm infants; however, this difference was determined to be statistically insignificant.

Ferritin levels are much higher in preterm labour patients than in low-risk women of the same gestational age. Serum ferritin levels may be utilised as a biomarker in high-risk premature labour.
Diagnostic performance of contrast enhanced computed tomography in intestinal obstruction
Authors: Kolluru Radhakrishna , M K Suma , Mohapatra Manoranjan , Das Swati , Sen Kamal Kumar , Madhesia Ajeet Kumar , Swaraj Sunny
Published: March 2024

Intestinal obstruction (IO) is a frequent cause of admission to the surgery and emergency departments. For the prevention of complications, such as ischemia and perforation, early recognition of IO is crucial. Computed tomography (CT) provides excellent details regarding cause, site & complications of IO and also helps in treatment planning.

To evaluate the efficacy and accuracy of CECT imaging in diagnosing IO and detecting complications. To correlate CECT findings with surgical or histopathological findings.

A prospective study was conducted in the Department of Radiology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India for a period of 2 years from September 2020 to September 2022. Fifty patients with suspected intestinal obstruction were evaluated, after obtaining informed consent. Data was analysed using SPSS 22 version software.

Male predominance was seen in this study, males constituted 58% and females 42%. The commonest age group affected was 41-50 years. Small bowel obstruction (SBO) was much more prevalent than large bowel obstruction (LBO). The most common site of BO was ileum. The leading cause of SBO was adhesions and in LBO was bowel malignancy.

IO is a fairly common presentation in clinical and radiological practice. There are various causes as well as mimickers of IO, which makes it a challenging task to accurately diagnose. CECT helps in treatment planning by providing information about bowel viability. We found it is extremely useful to include CECT study as a standard protocol in evaluation of patients presenting with bowel obstruction.
Evaluation of SOFA score (Sequential Organ Failure Assessment score) in hospitalised patients with sepsis
Authors: Chatterjee Santa Subhra , Mazumdar Amitava , Mandal Soumik
Published: March 2024

Considering sepsis as a common illness the following study studied the score and extrapolated with survival benefits in medical emergency patients. The score was made to determine population level burden of disease.

Various studies recommended SOFA for screening sepsis and determine prognosis. The score has been used to determine injury to organs in admitted patients with infection.

The cross sectional study was conducted at Vivekananda Institute of Medical Sciences, Kolkata over a period of one year (2019 till 2020) on sepsis patients admitted in medical ICU. The study revealed that more the scores on the day of admission, the more is the risk of adverse outcomes and subsequent early mortality (within day 7 of admission). In this study, among 56 cases of total death within the first 7 days of admission, 53 patients (94.64%) had day 0 SOFA score of >9 making it a significant outcome in this study. Baseline SOFA scores ≥ 9 and rising SOFA scores as day progresses can predict mortality in sepsis.

The mean SOFA score on admission to the ICU was 9.2. The 28-day mortality rate was 28%. Patients with a SOFA score of 9 or more on admission to the ICU had a significantly higher mortality rate than those with a score of less than 9 (42% vs. 14%, p < 0.01). The SOFA score on day 3 of ICU stay was also significantly associated with mortality (p < 0.01).

The SOFA score is a simple and easy-to-use tool that can be used to assess the severity of organ dysfunction in patients with sepsis. It is a good predictor of mortality in patients with sepsis admitted to the ICU.
Study of utilisation pattern and adverse reaction monitoring of drugs used for relief of musculoskeletal pain in a tertiary care teaching hospital in Eastern Odisha
Authors: Palai Sabita , Upadhyay Rajlaxmi , Upadhyay Manasaranjan , Misra Pooja
Published: March 2024

Musculoskeletal conditions are the most common cause of long-term pain and physical disability. The burden of musculoskeletal conditions is not only in terms of global numbers but also in terms of physical and psychosocial disability. Pain arising from musculoskeletal conditions of the major joints like back, neck, shoulder, knee or multi-site involvement results in diminished quality of life. Evidence for the effectiveness and safety of the various drugs used to alleviate MSP is uncertain.

The present study was an observational, cross-sectional study which included patients with complaints of musculoskeletal pain attending Regional Spine Injury Centre, S.C.B Medical College and Hospital. A total of 100 patients were included in the study. Demographic data of all the patients was collected and their level of significance in the causation of musculoskeletal pain was assessed. The prescription pattern of the drugs for musculoskeletal pain was analysed. All the patients taking the drugs were monitored for any adverse drug reaction and the same was documented.

Low back ache (28%) was the most common type of musculoskeletal pain observed. Aceclofenac was the most common analgesic prescribed, followed by paracetamol and etoricoxib. Aceclofenac and paracetamol was the most common combination used. Pain abdomen was the most common ADR encountered.
Evaluation of immunomodulatory effect of aqueous extract of aloe vera in Wistar albino rat models
Authors: Pradhan Rashmita , Singh Subhasish , Upadhyay Rajlaxmi , Singh Nipa , Ratha Bandana
Published: March 2024

Aim of the study wasto evaluate the immunomodulatory effects of Aqueous extracts of Aloe vera in Wistar albino rats using humoral immune response (antibody titre), a cellular immune response, and a neutrophil adhesion test after oral administration.

: 24 healthy Wistar albino rats of either sex were divided into 4 different groups containing 6 rats for each immunomodulatory model. Group I ,the control group received gum acacia suspended in normal saline; Group II rats were treated with dexamethasone (1 mg/kg bw)whereas Groups III & IV received AloeVera aqueous extract at a dose of 125 mg/kg and 250 mg/kg, respectively. Each rat was antigenically challenged by injecting 0.1 ml of 0.5 × 10 SRBCs (suspended in normal saline) intraperitoneally. The study of humoral immune response was seen by measurement of antibody titre obtained on 20 day (7 day of Ag challenge) and 27 day (14 day of challenge) with sRBC considered the primary and secondary humoral immune response, respectively. For the cellular immune response, foot pad edema was calculated due to a hypersensitivity reaction after injection of sRBC into the .rat hind paw. A test of neutrophil adhesion is used to evaluate immunomodulatory activity. Aloe vera aqueous extracts at 250 mg/kg significantly improved a significant increase in paw edema volume indicated increased cell-mediated immunity, and elevated Ab titre on the 20th and 27th days served as a marker of increased humoral immune response. Additionally, AVE 250 mg/kg caused an increase in neutrophil adhesion, demonstrating its immunomodulatory effects. Aloe vera aqueous extracts at a dose of 250 mg/kg demonstrated immunomodulatory activity in a model using Wistar albino rats.

Aloe vera extract at a dose of 250 mg/kg significantly increased hemagglutination antibody titers compared to the control group, indicating enhanced humoral immunity.

This study demonstrates the immunostimulant properties of orally administered Aloe vera aqueous extract in Wistar albino rats. The extract increased antibody production, enhanced cell-mediated immunity, and improved neutrophil function. These findings support the potential of Aloe vera as a natural immunomodulator and warrant further exploration of its therapeutic applications.
A study of clinical profile of snake bite at a tertiary care centre
Authors: G Anurekha , M Nallathambi , C Paranthakan
Published: March 2024

Because India has long been a land of exotic snakes, snakebite is a serious occupational and rural hazard. Physicians pay very little attention to this occupational hazard despite the high morbidity and death.

To study the various clinical profiles and the time interval between bite and start of treatment.

Patients were categorized based on the envenomation centred by patient history and definitive bite evidence and graded (I-IV) grounded on a series of manifestations observed in association with the onset of treatment time that distinguishes a venomous from a non-venomous snake attack. Patients were obligating local inflammation owing to tourniquet use besides local innate therapies.

Of the 100 patients deliberated, it was evident that there existed a minimal difference between the bites instigated by the snake type. Higher abnormal clotting was perceived on the arrival of patients (78%). While envenomation was predominantly reported to prompt primary coagulation abnormalities (84.32 %), neurotoxin manifestation was also found to occur at a lower rate (11.76 %). Both symptoms were also observed at a minimal level (3.92 %). Higher rates of renal failure were also reported and the clotting time normalization depended largely on patient admission time post-attack. In this investigation, the time gap between the bite and the commencement of therapy was not associated with the time required to normalize the coagulation abnormalities or develop a complication.

The study also proposes appropriate protective and awareness measures that could save humankind and these reptiles together.
Assessment of self-medication with analgesics among rural community of South India
Authors: S J Naresh Kumar , Sali Ramees M , Mokhasi Varsha R
Published: March 2024

World Health Organization defines self-medication (SM) as the self-administration of a medication in the absence of a current prescription and/or without consulting a healthcare professional. Analgesics are the most commonly abused drug as a self-medication for relieving pain of any kind among the people. Our aim was to assess the prevalence of self- medication with analgesics and find the social factors associated among the rural people in Southern India.

A community based cross sectional study using cluster sampling technique, four villages (clusters) were randomly selected in a rural District and among 460 respondents belonging to age group 18 to 60 years were interviewed.

The mean age in years was 48.4 ± 15.5. About 182(39.6%) were illiterates and many respondents belonged to Agricultural laborers 350(76.1). Self-medication with analgesics is practiced by 24.8% of the respondents. Reason for self-medication was to reduce the out-of-pocket expenditure (72.4%). About 65.8% respondents purchased analgesics over the counter from pharmacy.

The prevalence of self‑medication with analgesics was relatively high which is a threat for the community and can lead to multi organ damage to among rural people. Universal policy on drug selling over the pharmacy counter should be strictly implemented.
Prevalence and determinants of overweight and obesity among adolescent school children of Rajkot city, India
Authors: Mangrola Nidhi Y , Mahajan RG , Gajera Kshama D , Patel Kuntalkumar H.
Published: March 2024

Adolescent obesity is becoming more prevalent due to changing lifestyles, and it has negative effects like a higher incidence of non-communicable diseases. Identification of risk factors leading to the rapid rise in adolescent obesity is a crucial first step in preventing and controlling it. Therefore, this study was carried out in Rajkot.

The primary objective was to find the prevalence of obesity among the school going adolescents aged 14-19 years and to identify the determinants associated with obesity.

A cross-sectional study among the adolescents studying in school was carried out by using multistage sampling method. A predesigned questionnaire with personal and family history and details of dietary habits and physical activity was filled by the participants. Anthropometric measurements of the participants including height, weight, waist and hip circumference were taken.

Out of total 1120 participants, 25.8% were underweight, 11.1% were overweight and 6.9% were obese. Overweight and obesity was significantly associated with the occupation of participant’s father and mother, lack of physical activity, more screen time, non-vegetarian diet and daily consumption of carbonated drinks and chocolates. (p<0.001).

The determinants like physical activity and dietary habits were found to be associated with overweight and obesity. Modifying one's lifestyle can be very helpful in preventing adolescent obesity as well as developing healthy routines for later life.
To study thyroid profile in CKD patients in Eastern Uttar Pradesh
Authors: Srivastava Anupam , Mittal Mahim , Awasthi Minakshi , Rai Priyanka , Goel Mahima
Published: March 2024

Chronic kidney disease (CKD) remains a universal pandemic that has evolved into a serious public health problem that imposes a significant socioeconomic burden. Thyroid profile is disrupted in CKD patients due to aberrant thyroid hormone metabolism. The purpose of our study was to assess thyroid function in people who had chronic renal disease (CKD).

According to the inclusion-exclusion criteria, this cross-sectional observational research enrolled 150 chronic renal disease patients.All patients who met the above criteria underwent a detailed history as well as a general and systemic examination. Thyroid function tests, USG entire abdomen, chest X-ray, ECG, and 2D Echocardiogram, were performed.

There were 84 men and 66 women among the 150 CKD patients. Thyroid hormone abnormalities were found in 93.3 % of the individuals. 14.7 % of the participants had hypothyroidism, 14.7 % had low T3 and T4 readings, 10% had low T4 values alone, 38 % had low T3 only, and 17% had subclinical hypothyroidism. Low T3 levels (58 %) were the most prevalent thyroid anomaly, with or without low T4 or elevated TSH levels. Low T3 levels were more common in patients with advanced CKD.

Thyroid hormone abnormalities are linked to different stages of chronic renal disease.
Efficacy of Isosorbide dinitrate and Hydralazine combination in non ischemic dilated cardiomyopathy in a tribal based population at a tertiary care hospital
Authors: Sau Saikat , Mukherjee Lina , Sau Sourav
Published: March 2024

Non ischemic dilated cardiomyopathy is an important cause of heart failure and cardiovascular mortality. Numerous pharmacologic therapies have been applied from the ancient era for treatment. Some of them have shown improve morbidity. From various literatures it was concluded that combination therapy with H-ISDN in addition to conventional medicines are very effective in black population group. In our study we have tried to establish the efficacy of fixed dose drug combination (Hydralazine + Isosorbide dinitrate) to alleviation of heart failure symptoms and mortality benefit if any.

: Patient in NYHA 3 or ambulatory class 4 were included in study. Total two hundred populations were included in the prospective study. One hundred patients were treated by conventional optimum medications for heart failure including ACE inhibitors, ARBs. One hundred patients were given ISDN+Hydralazine (fixed dose) in addition to conventional medicines.

: Mean age of study and controlled group was 62.5 years and 61.4 years respectively. Base line mean ejection fraction in control group was 33% and study group was 33%. After a mean one and half year follow up 61% of patient population achieved NYHA 2 in case group and 53% in control group. We assess the NT pro BNP level in both group of population at baseline and every six month interval. There is significant reduction in BNP level in study patients. 72% achieved below baseline cut off value for the age in control. In control population 51% achieved the estimated BNP value cut off for age.

: Significant scope remains to improve the outcome for these patients through research related to use of H-ISDN in heart failure patients.
Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation using oral ivabradine – Randomised controlled trial
Authors: Bhuvana S , P Kanimozhi  , Sekar Arun , Latha N
Published: March 2024

Endotracheal intubation is one of the most common procedures, and anesthesiologists play an important role in patient care. During laryngoscopy and intubation, the patient can experience rapid and drastic hemodynamic changes that are potentially fatal.

The purpose of this study is to know the efficacy of ivabradine in attenuating the hemodynamic response to laryngoscopy and endotracheal intubation.

In this prospective randomised double-blinded study, fifty patients belonging to ASA 1 and 2 were randomised to group A - ivabradine 5mg (first dose on the evening before the day of surgery and the second dose one hour before intubation). Patients in group B received tablet MVT (placebo) (first dose on the evening before the day of surgery and the second dose one hour before intubation).

Patients in group A showed attenuation of heart rate during laryngoscopy and intubation till 10minutes after intubation. Patients in group B showed a rise in blood pressure during laryngoscopy and intubation till 10 minutes after intubation. Patients in group A and group B showed no significant difference in hemodynamics when monitored intraoperatively. All patients recovered fully from anaesthesia and had no complications such as severe bradycardia.

Ivabradine effectively attenuates the hemodynamic stress response without a fall in blood pressure and without severe bradycardia.
A study on the management of patients with retinopathy of prematurity in a tertiary care setting
Authors: Sethy Abinashi Sabyasachi , Sethi Santosh Kumar , Sharma Jyotsna , Murma Mangal Charan , Parida Subhabrata
Published: March 2024

Retinopathy of rashness (ROP) is a critical reason for youth visual deficiency which gives a window period to screening & treatment prior to advancing to an extreme structure having poor visual result. Universally, no less than 50,000 kids are visually impaired because of ROP & an extra obscure number will be outwardly impeded or blind in one eye.

To evaluate the administration of patients with Retinopathy of rashness & its result of the treatment applied in a tertiary level neonatal unit in the territory of Odisha.

It is a clinic based unmistakable (cross-sectional) study, done from September 2019 to October 2021 done at SNCU of SCBMCH, Cuttack & SNCU, NICU of Sardar Vallabh bhai Patel Postgraduate Foundation of Pediatrics (SVPPGIP), Cuttack, Odisha who qualify the incorporation standards.

During the review time of almost 2 years, 310 children were evaluated for ROP in which 117 were viewed as sure for ROP. The frequency of ROP in our review was 37.7%. ROP is viewed as related with the accompanying gamble factors in our review like low gestational age, low birth weight, oxygen treatment, RDS, paleness, blood bonding & septicemia, numerous births, hyperbilirubinemia with low birth weight & low gestational age & oxygen treatment being the main ones. Out of 31 cases treated with Avastin infusion, 26 gave indications of relapse till 2 months follow up & just 5 of them didn't give indications of relapse after infusion Bevacizumab. Those 5 children were treated with retinal removal by LASER photocoagulation following 10 days of beginning treatment, who gave indications of relapse till 2 months follow up.

Legitimate screening & the executives of ROP can prompt counteraction of movement of infection to a more extreme stage with poor visual guess, consequently decreasing the weight of experience growing up visual deficiency. Intra vitreal hostile to VEGF infusion can be utilized as essential treatment for treatment justified ROP cases however more examination is expected to figure out the drawn out incidental effect profile of these medications.
Результаты применения различных режимов применения препарата Суперлимф® в комплексном лечении пациентов с хроническим абактериальным простатитом
Authors: Гяургиев Т.А. , Енин И.Г. , Погорелов М.Д. , Ларин А.В.
Published: March 2024

В статье рассматриваются разные аспекты лечения и хронического абактериального простатита (ХАП), в развитии которого имеют значение защитные иммунные механизмы, изменение активности противо- и провоспалительных цитокинов. Статья направлена на исследование эффективности препарата Суперлимф® при включении его в комплексную терапию пациентов с ХАП.
Витамин С и наркотическая зависимость
Authors: Полякова И.С.
Published: March 2024

В статье описана возможность ослаблять наркотическую зависимость опиоидов с помощью витамина С. Применение витамина С в медицине требует дальнейших исследований, и возможно, область его возможностей не ограничивается общим повышением иммунитета. Витамин С может оказывать на организм не только общеукрепляющее действие, где он является незаменимым, но и вступать в реакции с другими веществами. В статье отмечено, что витамин С рвет связь, и наркотики становятся просто препаратом. Если принимать витамин С, то ослабляет наркотическая зависимость. Данные были получены экспериментальным путем и нуждаются в дальнейших исследованиях.
Гимнастика для плохого зрения
Authors: Чапкаева В.С. , Налимова М.Н.
Published: March 2024

Область науки постоянно развивается, появляются новые тенденции, направленные на решение различных аспектов здоровья и благополучия человека. Одной из таких набирающих обороты тенденций является развитие «гимнастики для глаз». Этот инновационный подход направлен на улучшение и поддержание здоровья глаз, повышение остроты зрения и борьбу с пагубным воздействием длительного времени перед экраном и других факторов, которые напрягают наши глаза. В этом отчете мы рассмотрим значение, преимущества, методы и потенциальные будущие разработки в области глазной гимнастики.
Typhoid Fever: A comparison among various age group people. A detailed case report and Review
Authors: Mamatkulova N.M. , Jayaraman R. , Periasamy Bharathi S. , Jothimani K. , Abdul G.S. , Balakumar G. , Anthony Peter I.D.
Published: March 2024

In this article, we took three cases from our locality in which we get to know about their common symptoms like fever, vomiting, diarrhea, irrespective of their age group but we also found that convulsion was a unique symptom of infant. We have also noted about the spiking pattern of fever on the evenings, for our reference we took data from National public health profile (2021) in which west Bengal has high case incidence in overall India.We have mentioned some drugs that are used in these cases, which could become resistant in upcoming years, so we have concluded that India should bring more programs and develop a newer drug to eradicate or to prevent an endemic.
Повышение эффективности культивирования сокультуры дермальных фибробластов/меланоцитов за счет внесения кластера витаминных добавок (В аспекте разработки эквивалента кожи)
Authors: Антонова Е.И. , Фирсова Н.В. , Ленгесова Н.А. , Ачилов А.Б.
Published: March 2024

Проведена оптимизация состава питательной среды и условий культивирования за счет внесения витаминного комплекса различной концентрации с целью эффективного культивирования клеточной сокультуры дермальных фибробластов/меланоцитов в аспекте разработки эквивалента кожи. Выявлено, что обогащение питательной среды витаминным комплексом, который включает в состав в основном витамины группы В, дозозависимо влияет на биологию сокультуры фибробластов/меланоцитов кожи в культуре. В процессе культивирования можно рекомендовать применение на ранних пассажах культивирования пятикратного раствора витаминного комплекса для накопления клеток в S-стадии клеточного цикла. На последующих этапах – однократного раствора для активации вступления клеток из Sстадии клеточного цикла в G2/M-стадию с увеличением пролиферативной активности клеток и как следствие увеличения числа жизнеспособных клеток сокультуры.
Влияние марганца на организм рыб: Ictalurus punctatus R. (1818) Heteropneustes fossilis, B. (1794)
Authors: Револьо И.А.
Published: March 2024

В статье сделан обзор научных исследований о влиянии марганца на организм рыб: Ictalurus punctatus R., (1818) и Heteropneustes fossilis B., (1794). Установлено, что добавление марганца в суточный рацион положительно влияет на изученные виды сомов. У канального сома эффектом марганца было повышение уровня белка, гликогена и снижение степени накопления липидов. В то время как добавление марганца в рацион мешкожаберного сома значительно влияет на показатели роста, использование корма, эффективность конверсии и антиоксидантный статус.
Копростаз у кошек
Authors: Калюх Е.А. , Шевченко А.Н.
Published: March 2024

В настоящее время, владельцы домашних животных, в частности, хозяева кошек, встречаются с заболеваниями кишечника. Копростаз – проявляется застоем содержимого в толстом отделе кишечника, который впоследствии уплотняется и высыхает. Основываясь на статистике, 35% от всех заболеваний незаразной этиологии, занимают патологии пищеварительной системы, в то время как заболевания желудочно-кишечного тракта 25% среди болезней собак и кошек [3]. В связи с этим, своевременное лечение и диагностика данного заболевания, является необходимым для сохранения нормальной жизненной активности животного, так как нарушение работы кишечника может привести к кишечной непроходимости, интоксикациям, болям, кислотно-щелочному и электролитному дисбалансу и истощению.
Химический эксперимент как средство формирования здорового образа жизни у школьников
Authors: Панова Ю.С.
Published: March 2024

Не секрет, что сохранение здоровья всегда было серьезной проблемой, но сегодня этот вопрос приобретает первостепенное значение. Формировать положительное отношение к здоровому образу жизни необходимо с малого. Важным помощником в этом деле является химический эксперимент.
Development of a method for cleaning gas emissions of industrial enterprises from hydrogen sulfide
Authors: Baghirova N.N. , Bayramova R.R.
Published: March 2024

Purification of gas emissions from various enterprises from hydrogen sulfide is one of the important environmental problems. Various methods are used to clean it. This article discusses the adsorption method of purification using granular carbonate sludge as an adsorbent. Its samples were obtained, and laboratory studies of the process of hydrogen sulfide adsorption from gas emissions were carried out.
Изучение порядка отнесения лекарственных препаратов к безрецептурным на территории РФ и отдельных аспектов реализации товаров безрецептурного отпуска
Authors: Амирджанова К.Г. , Сергеева Е.А.
Published: March 2024

В статье проанализирован порядок отнесения лекарственных препаратов к безрецептурным. Изучены основные действующие нормативно-правовые акты, регламентирующие порядок отнесения лекарственных препаратов к безрецептурным и требования к таким лекарственным препаратам. На примере отдельной группы проанализированы особенности реализации товаров безрецептурного отпуска.
Требования кукурузы к климатическим и почвенным условиям
Authors: Васильков П.Ф.
Published: March 2024

Загрязнение окружающей среды, ставшее глобальной экологической проблемой, делает особенно уязвимой почву, еѐ живую компоненту, в которой особую опасность представляют вещества микробного происхождения – микотоксины, вызывающие заболевания человека и сельскохозяйственных животных.
Роль физической культуры и студенческого спорта в продвижении ценностей здорового образа жизни в молодежной среде в современных условиях
Authors: Багдасарова П.А. , Служителев А.В.
Published: March 2024

Целью статьи является анализ роли физической культуры и студенческого спорта в продвижении ценностей здорового образа жизни в молодежной среде в современных условиях.
Использование мобильных приложений для мониторинга физической активности и здоровья
Authors: Волошин Р.М. , Ильин В.В. , Кузнецова З.В.
Published: March 2024

В данной статье рассматривается использование мобильных приложений для мониторинга физической активности и здоровья. Описываются основные функции таких приложений, их преимущества и недостатки. Также рассматривается влияние мобильных приложений на повышение мотивации к здоровому образу жизни.
Сохранение и укрепление здоровья студентов средствами физической культуры в вузе
Authors: Ибрагимов И.Ф. , Хусаинова Р.Р.
Published: March 2024

В статье «Сохранение и укрепление здоровья студентов средствами физической культуры в вузе» рассматриваются все составляющие способов, помогающих сохранить здоровье студентов. Рассматривается необходимость укрепления здоровья и важность занятиями физической культурой. Целью исследования является рассмотрение вопроса сохранения укрепления здоровья студентов средствами физической культуры в вузе. Задачами исследования является выявление эффективных способов сохранения здоровья студентов, проведение социологического исследования среди студентов КГЭУ. Методика исследования, применяемая в статье – анализ информации в сети-интернет, по соответствующей теме, наблюдение, сравнение. Результатом исследования является то, что большинство студентов КГЭУ (54%) занимаются спортом, и стараются придерживаться правильного питания. Выводы исследования заключаются в том, студенты действительно согласны с тем, что регулярная физическая нагрузка, правильное питание, здоровый образ жизни сохраняет и укрепляет здоровье не только учащихся вузов, но и любого другого человека.
Использование информационных технологий в работе современного педагога по физической культуре
Authors: Ибрагимов И.Ф. , Богданова М.С.
Published: March 2024

В статье «Использование информационных технологий в работе современного педагога по физической культуре» рассматриваются преимущества и вызовы, связанные с использованием информационных технологий, и предлагают практические рекомендации для эффективного использования этих технологий в педагогической практике. Результаты исследования позволяют сделать выводы о значимости информационных технологий в современном образовательном процессе и их потенциале для улучшения качества обучения физической культуре. Цель исследования - изучить влияние использования информационных технологий на работу педагога по физической культуре. Методы исследования. Для того, чтобы изучить выбранную тему, авторы применили социологические методы, позволяющие оценить степень использования педагогами информационных технологий в учебном процессе. Выводы исследования заключаются в том, что преподаватели активно используют информационные технологии в учебном процессе, но также сталкиваются с некоторыми проблемами при их использовании.
Физическая культура и спорт – основа здоровой и долгой жизни
Authors: Ибрагимов И.Ф. , Закирова Р.И.
Published: March 2024

В статье «Физическая культура и спорт – основа здоровой и долгой жизни» рассматриваются все составляющие физического здоровья человека, а также предлагаются рекомендации, следование которым будет способствовать здоровой и долгой жизни. Целью исследования является выявление ответа на вопрос: почему физическая культура является основой здоровой и долгой жизни. Задачами исследования является выявление факторов, влияющих на здоровую и долгую жизнь человека, а также определение преимуществ для людей от занятий спортом. Методика исследования, применяемая в статье – анализ информации в сети-интернет, по соответствующей теме, наблюдение, сравнение. Результатом исследования является то, что большинство студентов КГЭУ (67%) ведут активный образ жизни; правильное питание, спорт, правильный распорядок дня и психическое здоровье составляют основу долгой жизни. Выводы исследования заключаются в том, что активные занятия спортом, регулярные тренировки и правильное питание будут способствовать лучшему самочувствию и долгой жизни.