bluuebunny/crossref_metadata_2025 huggingface dataset:
Fire safety of timber buildings – The case of photovoltaic systems
Authors: Rus Nik , Lucherini Andrea , Jomaas Grunde , Derikvand Mohammad
Published: February 2025

Photovoltaic (PV) systems play an important role in reducing society’s dependence on carbon-based energy sources, and their coupling with timber buildings is an interesting and expected solution for meeting sustainability requirements in the modern built environment. However, both PV systems and timber structures have unique fire safety challenges, and their combination may introduce additional risks. Therefore, relevant fire hazards associated with each of the technologies and their pairing are discussed. The findings highlight the importance of revising fire testing standards and developing tailored safety measures to identify and manage these risks.
Gut–brain connection in multiple sclerosis
Authors: Dziuba Gabriela , Golemo Jagna , Szpyra Justyna Honorata , Dębińska Julia , Celichowska Magdalena , Kałuża Izabela , Górska Magdalena , Serkis Barbara , Bogoń Aleksandra , Ostojska Magdalena
Published: February 2025

Introduction and objective: The link between gut microbiota and multiple sclerosis has gained significant research interest in recent years. Multiple sclerosis, an autoimmune disease characterised by chronic inflammation and demyelination in the central nervous system, remains a complex condition with a multifactorial aetiology. Recent evidence suggests that alterations in gut microbiota composition, known as dysbiosis, may influence multiple sclerosis pathogenesis and progression. This paper aims to review the current state of knowledge regarding the gut–brain connection in multiple sclerosis, exploring how gut microbiota may affect disease mechanisms and potential therapeutic approaches. Summary of the state of knowledge: The gut–brain axis plays a crucial role in maintaining homeostasis. In multiple sclerosis, dysbiosis has been observed, with specific microbial profiles differing between patients and healthy controls. Gut microbiota can modulate immune responses, potentially influencing multiple sclerosis progression through pathways involving cytokine production and T-cell differentiation. Therapeutic interventions such as dietary modifications, probiotics, and faecal microbiota transplantation have shown promise in preliminary studies, indicating their potential to modulate gut microbiota and improve patient outcomes. Summary: Understanding the gut–brain axis in multiple sclerosis offers promising possibilities for new therapeutic strategies. Interventions targeting gut microbiota, such as probiotics, dietary changes, and faecal microbiota transplantation, show potential for modifying disease progression and enhancing treatment outcomes. However, current methodologies for assessing gut microbiota have limitations, requiring improved techniques for accurate analysis. Continued investigation into the gut–brain connection could lead to more effective and targeted treatments, ultimately improving the quality of life for multiple sclerosis patients.
Filling gaps in the southern range of the Endangered Chacoan Peccary, Parachoerus wagneri (Rusconi, 1930) (Artiodactyla, Tayassuidae), in Argentina
Authors: Wajner Matias , Merlo Francis , Argibay Daihana , Zamudio Fernando
Published: February 2025

New records of the Endangered Parachoerus wagneri (Rusconi, 1930) are reported in northwestern Córdoba and south Santiago del Estero, Argentina. These records were obtained through interviews, confirmed with photographical evidence provided by the interviewees, and trail camera surveys. These findings confirm the presence of this species in strategic areas of its distribution and provide evidence of potential connection between northern and southern populations in Argentina. Participatory sampling is proving to be an essential tool for gathering high quality information in these areas, thus has become crucial in obtaining records and clarifying the distribution of P. wagneri.
Internações hospitalares por esquizofrenia no Brasil: estudo do perfil e tendência temporal entre 2010 e 2023
Authors: Truppel Simas Jasmine , Eloise Parizotto Pereira Júlia , Cascaes da Silva Franciele , Otília Nazário Nazaré , Da Rosa Iop Rodrigo
Published: February 2025

Estudo ecológico do tipo misto com o objetivo de investigar o perfil epidemiológico e a tendência temporal de internações hospitalares por esquizofrenia no Brasil, entre 2010 e 2023. Para o estudo de série temporal, analisou-se as taxas de notificação padronizadas e o método de regressão linear simples a partir do número de internações hospitalares por esquizofrenia, conforme sexo, faixas etárias por sexo e regiões brasileiras. Já o estudo do perfil, realizou a análise descritiva da faixa etária, sexo, cor da pele, regime e caráter de atendimento, tempo de internação e custos hospitalares. Os resultados apontaram 1.082.576 internações hospitalares por esquizofrenia, com maior prevalência em homens entre 20 e 39 anos, da cor parda, bem como um custo total de R$2.514.383.318,52. Houve tendência linear decrescente da taxa geral de internações em ambos os sexos. A região Norte, diferente das demais regiões, apresentou uma tendência linear crescente. São 1,6 milhões de brasileiros que convivem com a esquizofrenia e os investimentos se aproximam de 794 milhões de reais por ano, representando um importante agravo em saúde pública, sobretudo no âmbito socioeconômico. Assim, faz-se necessário conhecer a tendência do adoecimento e estimar o impacto socioeconômico que essa condição acarretou no Brasil e no mundo nos últimos anos.
Understanding the role of a programme delivery partner (PDP): an exploratory study, part 1: problem formulation and emergent themes
Authors: Botelle Matthew , Addyman Simon
Published: February 2025

Globally, major infrastructure programmes are growing in scale and complexity, presenting significant challenges for clients in establishing organisations that are capable of creating value over the long term. In response, clients increasingly engage Programme Delivery Partners (PDPs) to navigate these complexities. However, traditional programme management and commercial frameworks are often seen as constraining rather than enabling the evolution of the PDP and there is a noticeable absence of an established body of knowledge for this particular type of organisational arrangement. To address this issue, Parsons, and University College London (UCL) engaged in an exploratory study of knowledge co-creation through the method of Engaged Scholarship (ES).
Motivating Grade 12 learners at a quintile 3 secondary school in South Africa
Authors: Ismail Thaabit , Mda Thobeka , Mashiyi Nomakhaya
Published: February 2025

This study identifies factors that motivated Grade 12 learners at a quintile 3 secondary school in post-apartheid South Africa. A phenomenological qualitative approach was adopted. Semi-structured interviews were used to collect data from Grade 12 learners. Human Motivation theory and Self-determination theory were synthesised to form an underpinning theoretical structure. The results of the research study identified various factors that motivated Grade 12 learners: parental involvement, affirmation, and enjoyment of subjects. Knowing about such factors and applying motivational interventions at schools in poor areas affirms learners and empowers them to escape destitution, despair, cycles of illiteracy and poverty, and the bonds of a racist past. Teachers and parents should be cognisant of such important factors. School communities, particularly those in economically challenged areas, need to be made aware of the value of such motivating factors.
THE UNICORN BABY. Debunking 10 Myths of Modern Parenting
Authors: Walker René
Published: February 2025

A book review of the book:The Unicorn Baby.  Debunking 10 mythis of Modern Parenting
Cultivating socially just responsible citizens in relation to university accounting education in South Africa
Authors: Terblanche Judith , Waghid Yusef
Published: February 2025

The aim of this study – situated within the particular South African context that has been marred by systemic inequality and social injustice – was to determine whether higher education institutions could cultivate and nurture socially responsible democratic citizens. Secondary research questions focused on the required teaching and learning practices that support democratic citizenship education, and on the identity of the university educator responsible for implementing these teaching and learning practices. In particular, the focus was on the advantages of utilising deliberative encounters as a pedagogical strategy in higher education. In the development of the study, the emphasis particularly shifted to the consideration of whether deliberative encounters could assist in cultivating socially responsible chartered accountants. The research approach used was pragmatism, which was appropriate to focus on the possible responses to existing societal problems. Within this framework, deconstruction was applied as method in order to determine whether any marginalised voices were absent from this particular discourse. Through applying Foucault’s genealogical analysis to the chartered accountancy educational landscape in South Africa, three mechanisms of disciplinary power were identified, namely the accreditation process, the issue of a competency framework and the writing of an examination. As a result of these mechanisms in operation, it was found that critical thinking pertaining to knowledge construction, the decoloniality of the curriculum, deliberative encounters as teaching and learning practice, and principles in support of the ubuntu practice were largely absent from the chartered accountancy educational landscape. In response to the above-mentioned findings, the study proposes that the re-education of the chartered accountancy profession should include a re-negotiation of the relations and roles of each stakeholder involved in the education process. The study further argues for a transformation in terms of the identity construction of a chartered accountant. Chartered accountants should primarily identify as responsible future business leaders with a unique professional skill set as secondary requisite. Furthermore, various teaching and learning practices that support democratic citizenship education and which could result in the cultivation of socially responsible chartered accountants should be adopted by chartered accountancy university educators at higher education institutions.
Strategies used by peer-led groups in the provision of Psychosocial Social Support in schools
Authors: Chinyama Nyarayi , Rembe Symphorosa , Sibanda Octavia
Published: February 2025

The study sought to find the strategies used by peer-led groups in the provision of Psychosocial Social Support (PSS) to vulnerable children in secondary schools in Amathole West Education District, Eastern Cape, South Africa. The Psychosocial Support interactive model of 1982 by Merriam and Darkenwald informed this study. A qualitative approach with a case study research design was used as a method of inquiry and was underpinned and framed by the interpretive paradigm that guided the researchers as they generated the data. The target population was all the schools in Amathole West Education District. Four secondary schools were chosen as multiple case studies because they had functional peer-led groups. A sample of 41 participants made up of four peer leaders, four learner support agents, four principals, four Life Orientation (LO) teachers, one district offocial and 24 learners in focus groups was purposively selected because they were directly involved with the peer-led groups. A thematic text analysis was used and the study revealed that peer-led groups employed four strategies: counselling, referrals, partnerships and circles of friends. The study concluded that vulnerable learners who were identified could not be effectively assisted due to a shortage of resources such as counselling rooms and transport as well as lack of training of the peer leaders. The study recommends that peer-led programmes should be part of the large school curriculum with a specific budget to meet the requirements of such programmes.
A reflection on the ‘non-place’ character of German foreign language (GFL) courses and coursebooks in South African higher education
Authors: Engelbrecht Natasha
Published: February 2025

This paper argues that the reductionist, and increasingly trivial, nature of foreign-language textbooks has an adverse impact on how German language, culture and society are represented and perceived by foreign-language learners in South Africa reframing German-speaking countries as ‘non-places’. Reflecting on a coursebook prescribed at a South African university, this paper posits further that coursebook users, especially learners, are decontextualised and perceived to be homogenous by publishers who are guided by a construct of the average learner. This paper maintains that teaching coursebooks without adaptation to incorporate students’ epistemologies and ontologies endorse a ‘non-place’ classroom. Such practice perpetuates alienating conditions lamented in discourses common to higher education (HE) institutions which are facing calls for transformation. The paper examines the non-place representation of German-speaking contexts in German Foreign Language (GFL) coursebooks and its creation of a non-place classroom. Following a consideration of the disciplinary aims of German courses in South African HE, the paper advocates a curriculum which fosters a critical engagement with coursebook content. Finally, it argues that by cultivating learner-responsiveness in language courses, and by localising content, one can withstand a foreign language classroom which is devoid of place and belonging.
Understanding the efficiency of teaching through YouTube vs PowerPoint on concept acquisition by second-year chemistry pre-service teachers
Authors: Bhagwandeen Dr Ritu
Published: February 2025

Studies indicate that YouTube and YouTube EDU are very popular tools for digital teaching and learning. However, students from disadvantaged communities have significant gaps in experiences, knowledge of the world, and access to enrichment options such as YouTube. The objective of this study was to test the effectiveness of YouTube versus PowerPoint presentation as a teaching tool to improve overall conceptual understanding of the topic, States of Matter, by 62 second-year pre-service teachers. A quasi-experimental design was used to select the groups conveniently; one group was used as an experimental group (n=31) and the other group was the control group (n=31). A pre-test for both groups was conducted on the first day at the same venue at the time when academic activities commenced at the university. The experimental group as well as the control group consisted of seven (7) males (22.58%) and 24 females (77.42%). A paired-samples t-test was conducted to evaluate the effectiveness of teaching through YouTube versus PowerPoint presentation. There was a statistically significant difference between the experimental (p=0.000) and control group (p=0.003) results. The findings of this study indicate that science lecturers can convey information to their students via digital media, devices, and techniques to improve the understanding of chemistry content. This creates sustainable teaching and learning spaces that will improve overall teaching and learning.
A visszatérő oktatás ellentmondásai – felnőttképzési tanfolyamok tapasztalatai
Authors: Fónai Mihály , Nyilas Orsolya
Published: February 2025

Az élethosszig tartó tanulás paradigmája azon a feltevésen alapul, hogy a versenyképes tudásalapú társadalomban és gazdaságban egyre nagyobb az igény arra, hogy a felnőttkori tanulást segítő intézmények igazodjanak az egyéni és közösségi elvárásokhoz, hogy az egyének életük bármely szakaszában elkezdhessenek tanulni, bármilyen tanulási formát választhassanak. Ezzel összefüggésben az 1970-90-es években a felnőttkori tanulást jelentősen meghatározták azok az elméleti koncepciók, modellek melyek a visszatérő oktatással (recurrent education) kapcsolatban jelentek meg és nyertek alkalmazást a lifelong learning fogalmán belül, a rekurrens oktatás koncepciójának részeként. Tanulmányunkban támogatott munkaerőpiaci képzések eredményességét és a részvevők motivációit, véleményét, elvárásait elemezzük. A képzések résztvevőivel kérdőíves adatfelvétel és fókuszcsoportos interjú készült Nyíregyházán, 2012-19 között, öt tanfolyam keretében. A kutatás eredményei közül a „visszatérő oktatást” (más fordításban „ismétlődő oktatást”) alakító főbb jelenségek, változók hatásait mutatjuk be. Kutatásunkat feltáró, problémamegfogalmazó jellegűként értelmezzük, tekintettel a visszatérő oktatás kapcsán megfogalmazott állításunkra, mely szerint a visszatérő oktatást és a képzésekben való részvételt sok esetben a külső kényszerek alakítják (a kutatás feltáró jellege ellenére az alaptézis tesztelése miatt fogalmaztuk meg hipotéziseinket).
MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries). A gender disease?
Authors: Orsini Enrico
Published: February 2025

Nei pazienti con sindromi miocardiche ischemiche, acute e croniche, la prevalenza di coronarie normali o l’assenza di aterosclerosi ostruttiva non è certo l’eccezione. INOCA (Ischemia with Non-Obstructive Coronary Arteries) interessa dal 25% all’80% delle forme croniche. MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries) rappresenta globalmente il 4-30% di tutti gli infarti. La loro prevalenza sta aumentando a livello di popolazione, per l’efficacia degli interventi di prevenzione primaria e per il controllo dei fattori di rischio per le malattie aterosclerotiche. MINOCA si può verificare per rottura, erosione o trombosi in situ di placche coronariche non ostruttive (stenosi <50%); per dissezione coronarica spontanea; per spasmo coronarico epicardico; per spasmo o disfunzione microcircolatoria; infine per mismatch fra domanda e offerta di energia. Anche se la prevalenza globale è inferiore nelle donne rispetto agli uomini, le malattie cardiovascolari rappresentano la principale causa di morte anche nel sesso femminile (35%). Fra le malattie cardiovascolari, la cardiopatia ischemica è la prima causa di mortalità cardiovascolare, nelle donne come negli uomini. Vi sono tuttavia importanti differenze epidemiologiche, patogenetiche e prognostiche nelle caratteristiche delle sindromi ischemiche fra i due sessi. Le donne sono colpite da infarto ad una età più avanzata rispetto agli uomini (63 verso 54 anni per MINOCA; 66 verso 59 anni per MIOCA – Myocardial Infarction with Obstructive Coronary Arteries). La prognosi a breve e lungo termine, sia per MINOCA che per MIOCA, è nettamente peggiore nelle donne che negli uomini: maggiore mortalità e MACEs nelle donne per MIOCA; maggiore incidenza di MACEs nelle donne per MINOCA. Per quanto riguarda le caratteristiche patogenetiche, nelle donne i fattori funzionali micro e macrovascolari giocano un ruolo più rilevante rispetto agli uomini. La prevalenza di MINOCA, fra tutte le forme di infarto, è infatti 10-30% nelle donne e 4-15% negli uomini. MINOCA è dunque una sindrome eterogenea, sostenuta da cause diverse, con una presentazione clinica multiforme e molte differenze di genere. Anche se nelle donne ha una prevalenza maggiore rispetto agli uomini, MINOCA non è esclusivo o tipico in uno dei due generi, ma è significativamente rappresentato sia nei maschi che nelle femmine.
Lysosomal and mitochondrial functional assays in human neurons v1
Authors: Chou Ching-Chieh , Frydman Judith
Published: February 2025

Cellular assays to test lysosomal and mitochondrial functions in human neurons at basal and stressful conditions.
Automated combinatorial media preparation v2
Authors: Radivojevic Tijana , Incha Matthew , not provided vblayroger , Zournas Apostolos , Tan Stephen , Garcia Martin Hector
Published: February 2025

Although synthetic biology can produce valuable chemicals in a renewable manner, its progress is still hindered by a lack of predictive capabilities. Media optimization is a critical, and often overlooked, process which is essential to obtain the titers, rates and yields needed for commercial viability. Here, we present a molecule- and host-agnostic active learning process for media optimization that is enabled by a fast and highly repeatable semi-automated pipeline. Its application yielded 60% and 70% increases in titer, and 350% increase in process yield in three different campaigns for flaviolin production in Pseudomonas putida KT2440. Explainable Artificial Intelligence techniques pinpointed that, surprisingly, common salt (NaCl) is the most important component influencing production. The optimal salt concentration is very high, comparable to seawater and close to the limits that P. putida can tolerate. The availability of fast Design-Build-Test-Learn (DBTL) cycles allowed us to show that performance improvements for active learning are rarely monotonous. This work illustrates how machine learning and automation can change the paradigm of current synthetic biology research to make it more effective and informative, and suggests a cost-effective and underexploited strategy to facilitate the high titers, rates and yields essential for commercial viability. Here we provide the protocol for automated media optimization on a flaviolin producingPseudomonas putida KT2440 strain.
Bacterial Isolate Genomic DNA Isolation - ONT NO-MISS v1
Authors: Carlos Goller Carlos
Published: February 2025

Overview and Goals Your bacterial isolate has been grown on agar plates. We now need to lyse open the bacteria and isolate only the genomic DNA for sequencing. We need to lyse the bacteria with enzymes and a lysis buffer for this. We will then purify the genomic DNA. We will use a modification of the NEB Monarch Spin Column Kit extraction kit. This protocol has been recommended by Oxford Nanopore Technologies (ONT), the company that makes the sequencer we will use for sequencing our bacterial genomes. On the left are healthy living bacteria (An example is Bacillus). On the right, the bacteria are lysed open, which results in cell death. Consider this question as you read the protocol: How will we facilitate bacterial lysis? Images of Bacilli werecreated using BioRender.com. Learning Objectives After completing this lab you will gain the following lab skills: Lab safety and proper personal protective equipment (PPE) Proper use of a centrifuge and pipettors Isolation and purification of genomic DNA
Absorbance assay from an M2P flower plate v2
Authors: Radivojevic Tijana , Zournas Apostolos , not provided vblayroger , Garcia Martin Hector
Published: February 2025

Although synthetic biology can produce valuable chemicals in a renewable manner, its progress is still hindered by a lack of predictive capabilities. Media optimization is a critical, and often overlooked, process which is essential to obtain the titers, rates and yields needed for commercial viability. Here, we present a molecule- and host-agnostic active learning process for media optimization that is enabled by a fast and highly repeatable semi-automated pipeline. Its application yielded 60% and 70% increases in titer, and 350% increase in process yield in three different campaigns for flaviolin production in Pseudomonas putida KT2440. Explainable Artificial Intelligence techniques pinpointed that, surprisingly, common salt (NaCl) is the most important component influencing production. The optimal salt concentration is very high, comparable to seawater and close to the limits that P. putida can tolerate. The availability of fast Design-Build-Test-Learn (DBTL) cycles allowed us to show that performance improvements for active learning are rarely monotonous. This work illustrates how machine learning and automation can change the paradigm of current synthetic biology research to make it more effective and informative, and suggests a cost-effective and underexploited strategy to facilitate the high titers, rates and yields essential for commercial viability. This protocol explains the steps for preparing samples and taking OD600 and OD340 measurements from a BioLector plate.
Evaluación de lesiones apicales en dientes con obturación endodóntica a partir de tomografías computarizadas de haz cónico (CBCT), usando el índice periapical (PAI) modificado
Authors:   Universidad Autónoma de Manizale, Rodríguez-Lezama Didier , Mena-Falla Julián Camilo ,   Universidad Autónoma de Manizale, Duque-Gómez Luz Eugenia ,   Universidad Autónoma de Manizale, Grajales-Garay Yolanda ,   Universidad Autónoma de Manizale, Castro-Castaño Estephania ,   Universidad Autónoma de Manizale
Published: February 2025

Introducción: la periodontitis apical (PA) suele presentarse sin síntomas y su diagnóstico se realiza principalmente a través de imágenes radiográficas. Utilizando la tomografía computarizada de haz cónico (CBCT) se pueden estudiar áreas radiolúcidas perirradiculares a partir de referentes anatómicos reproducibles. Este estudio pretendía caracterizar con CBCT mediante el PAI modificado (índice periapical, de las siglas en inglés) las lesiones perirradiculares (LP) en dientes con obturación endodóntica. Métodos: estudio descriptivo. Fueron analizadas 1113 tomografías que presentaban lesión apical (165 pacientes, equivalentes a 192 dientes con 396 conductos) según criterios de inclusión. Los errores técnicos asociados al tratamiento endodóntico fueron registrados. El tamaño de la lesión fue caracterizado a partir del CBCT/PAI (Estrela, 2008). Se calcularon medidas de tendencia central y dispersión. Resultados: en promedio las lesiones presentaron de alto 5,24 mm, ancho 4,73 mm y profundidad 4,92 mm. Las lesiones se encontraron en un 46,35% en la categoría 3, un 40,1% en la categoría 4, un 10,42% en la categoría 5 y un 3,12% en la categoría 2. Los errores evaluados fueron: subobturación (68,01%), sobreobturación (6,8%), conducto no tratado (4,3%), perforación radicular (1,2%) e instrumento fracturado (0,25%). Conclusión: el 85% de los dientes tratados endodónticamente con LP presentaron un error en el procedimiento, siendo la subobturación lo más predominante con un tamaño de lesión entre los 3 y 8 mm (categorías 3 y 4). Esta condición debe llamar la atención de la comunidad odontológica en pro de fomentar nuevos protocolos de evaluación, tratamiento y control.
THE NEURODYNAMICS OF α EEG BAND UPON MENTAL ARITHMETIC TASK PERFORMANCE BEFORE AND DURING THE FULLSCALE RUSSIAN INVASION
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, CHERNYKH Mariia , KRAVCHENKO Viktoriia ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, RESHETNIK Yevdokiia ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, ZYMA Ihor ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: February 2025

Background. Living in war-affected zones has been found to significantly impact cognitive functions, mental health, and overall well-being in children, adolescents, and adults. Stress perception plays a role in this impact, with the psychological burden of war impairing cognitive development and functioning in youth and adults. Neurodynamics associated with managing the cognitive workload and stress is well-reflected in the EEG data, as chronic stress exposure significantly affects cognitive performance. The α EEG band has been widely investigated as a biomarker for assessing cognitive performance, mental fatigue, and the effects of interventions to enhance cognitive function. However, there is not enough data regarding the α band dynamics under the impact of long-term stressors, such as living in a war-torn country, especially during cognitive load. The study aimed to compare the α EEG band neurodynamics associated with the mental arithmetic tasks before and during the outbreak of Russia’s full-scale invasion of Ukraine.

Methods. Fifty-seven volunteer subjects participated in the study; twenty-eight (nfem=15) were enrolled before the full-scale invasion, and twenty-nine (nfem=18) after the invasion outbreak. The EEG data were recorded during the sequential subtraction performance, with further subband selection, viz α1 [7.5, 9.5] Hz, α2 [9.6, 11] Hz, α3 [11.1, 12.9] Hz.

Results. In the α1 subband, the female group exhibited an increased number of coherent neural connections during the full-scale invasion. In the α2 subband, a topographical redistribution of connections was noted for the male group, namely the decrease of connection number and shift towards the frontal areas of the cortex. In the α3 subband, the female group showed a wide network of connections, compared to the male group, where a distinct parietal-predominated hub of connections was observed during the full-scale invasion.

Conclusions. It was discovered that female subjects showed higher degrees of behavioral inhibition during full-scale invasion, which could be interpreted as a covert indicator of elevated background anxiety. The male group demonstrated difficulties focusing their attention on the internal task. Lastly, volunteers in both groups showed an overall decline in the efficacy of top-down control over the task execution.
THE EFFECT OF COMMON BEAN HUSK PEPTIDES ON BLOOD GLUCOSE LEVELS IN RATS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, SHCHYPANSKYI Serhii , SAVCHUK Oleksii ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, HALENOVA Tetiana ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: February 2025

Background. Plant-derived peptides, especially those from beans, hold immense potential for therapeutic applications. They are readily available, produced without animal use, and offer numerous advantages over conventional medications. Studies demonstrate their antimicrobial, antioxidant, and anti-glycemic properties. Bean husks, typically discarded, are a valuable source of bioactive compounds. Their accessibility and low cost make them attractive for biotechnology. Our research focuses on the isolation and investigation of peptides from bean husks, particularly their hypoglycemic properties.

Methods. To obtain the peptide fraction, we prepared an aqueous extract of dry bean husks by boiling, followed by acid hydrolysis of the protein-containing solution, its boiling and centrifugation. In order to get rid of small non-protein molecules, we have performed dialysis of obtained peptide mixture. To assess the impact of peptides on blood glucose levels, we conducted an oral glucose tolerance test on overnight-fasted rats, comparing the results of experimental animals that received peptides with control animals that received water, and measuring animals' glucose levels every 30 min.

Results. In our study, peptides from bean husks initially temporarily increased glucose levels in rats, that received them instead of water (by 26 %). But after glucose administration, blood glucose levels in the experimental group (that received peptides) increased significantly less – only by 4.6 %, comparing to period after peptide administration and by 39 %, comparing to the glucose levels at the beginning of experiment. Meanwhile, the control group's blood glucose levels increased by 50 %, (from 4.05 mM/L to 6.1 mM/L). Ninety minutes after glucose administration, glucose levels in both groups decreased – by 11 % in control group, and by 6 % in experimental group, resulting in statistically similar blood glucose levels in both groups.

Conclusions. Initially, the glucose levels in rats that consumed peptides increased. This may be due to the presence of carbohydrates in the peptide solution. However, after glucose administration, the glucose level in the experimental group increased much slower than in the control group. This suggests that peptides may affect glucose utilization, for example, on glucose transporters or insulin secretion. The results show that peptides from bean husks can mitigate the sharp rise in glucose levels, which may be beneficial for people with impaired glucose tolerance. Further research will help to elucidate the mechanism of action of peptides and their potential applications.
A POÉTICA DO SUICÍDIO EM SYLVIA PLATH
Authors: Carvalho Ana Cecília de
Published: February 2025

Para questionar se haveria ou não uma função supostamente terapêutica na escrita literária e propor a ideia de uma "toxidez" na escrita, este artigo examina a presença e os efeitos de elementos destrutivos no que é escrito aqui como uma "poética do suicídio" na literatura de Sylvia Plath
Loyalty and perceived value in mobile telecommunications services in Colombia
Authors: Rojas Berrio Sandra Patricia , Valencia Cifuentes Ckayrom Alfonso
Published: February 2025

It is essential for telecommunications operators to implement strategies aimed at building customer loyalty in order to improve their financial performance. One key factor that positively influences customer loyalty is perceived value, which should be considered in marketing strategies to strengthen this relationship. This study aims to analyze the connection between loyalty and perceived value among mobile telecommunications customers in Colombia. The hypothesis proposes a relationship between the dimensions of value and loyalty, based on a previously developed scale. Using a methodological approach that includes 406 surveys of mobile service users in Colombia, the relationship between these constructs is verified. The results indicate a positive and direct relationship between loyalty and perceived value across the four proposed dimensions
Level of Maturity Regional Innovation System as an Effort Improving Public Services
Authors: Hidayat Bachtari Alam , Akbar Alexander , Faturohim Agus
Published: February 2025

Regional innovation system is related to the entire process of developing innovation between government institutions, research institutions, business entities, and the community that prioritizes science, technology, and the development of new methods. The purpose of this research is to identify and analyze the types and groups as well as the maturity of regional innovations in the city of Palembang and include them in the regional innovation map. The data collection method used was interview with relevant stakeholders, such as government officials, academics, and p­­­­ractitioners involved in the development of regional innovations and public services. Observation, which is a method of collecting data by making direct observations on regional innovation systems and public services in a number of selected regions. Questionnaire, which is a method of collecting data using questionnaires filled out by a number of related respondents, such as government employees and communities involved in or receiving public services in the area studied. The results of this study show that the regional innovation development roadmap for the city of Palembang until 2019 has totaled 126 innovations issued by the regional organization (OPD), but there are still many programs that are at the initiation stage so efforts are needed to develop infrastructure, human resources, regional funding to policies capable of making innovations run sustainable. Efforts to accelerate the implementation of governance reforms in the regions need to be encouraged through innovation programs for all regional government administration affairs. Therefore, the development and implementation of innovation in the regions is not only limited to the internal bureaucracy, but also must be encouraged to the private sector and the community which is expected to increase regional competitiveness.
Analyzing Tourism Promotion and Service Tactics for Wanurejo Village’s Visitor Growth
Authors: Rosdiana Anggita Cahya , Dwihantoro Prihatin , Fitri Shakira Insanu
Published: February 2025

Tourism is a sector that can increase the amount of state revenue. This sector is used as an economic activity that accommodates many employment opportunities for the surrounding community, so as to increase income and community welfare. Like the Tourism Village in Borobudur, Magelang Regency, this tourism village develops several attractions in the form of natural tourism, cultural community activities and craft centers. This research targets to identify the situation of Wanurejo village tourism gadgets within the new everyday generation, secondly to find out the promoting strategy to growth the number of site visitors, thirdly to find out tourism offerings geared toward growing the wide variety of traveler traffic. This study makes use of descriptive-qualitative research whilst data series techniques use interviews, remark, and documentation. Wanurejo Tourism Village are several potentials such as tourism, arts, culinary, crafts, village events, and homestays. The result of the research obtained are that wanurejo village implements a promotion strategy in the new normal era using conventional and online strategies, social media and website are one of the media used in promoting wanurejo tourist village.
The Effectiveness of Interpersonal Communication of Faith-Based Organizational Media Team in Producing Dakwah Content
Authors: HRP Sri Maharani , Fauziah Kholifatul
Published: February 2025

This study aims to explain the effectiveness of the faith-based media team's interpersonal communication as a team that produces da'wah content in Indonesia. At first, the spread of Islamic teachings in Indonesia developed only in mosques, but over time, da'wah has evolved into digital da'wah (da'wah through online media). anything that can be used to spread da'wah content. Because of this, the Muhammadiyah Central Leadership digital tabligh studio team, as the team that produces da'wah content, is deemed necessary to attach the effectiveness of interpersonal communication to facilitate the process of producing da'wah content. This organization is a non-profit organization engaged in charity and business that generally relies on volunteers to develop the organization. Theoretically, this research has implications for the effectiveness of interpersonal communication in related organizations in creating da'wah content. This study uses a descriptive qualitative approach. The use of this method is considered to be able to describe in detail the problems studied. Furthermore, this study will explain how the effectiveness of interpersonal communication of the digital tabligh studio team in producing da'wah content. Then, this study will identify what factors, both internally and externally, can influence the effectiveness of interpersonal communication of the digital tabligh studio team in creating da'wah content.
Proses Komunikasi Empatik Antara Perawat Dengan Pasien Lansia di Panti Jompo Tresna Werdha, Kasihan, Bantul
Authors: Putri Devi Lianda , Suciati Suciati
Published: February 2025

Empathic communication is a way to gain awareness and understanding of the conditions of other people or elderly patients through communication. Thus, the empathic communication process plays an important role in establishing a closeness between nurses and elderly patients. Empathic communication can be manifested in the form of attention, care, and being able to feel what the elderly are experiencing. The purpose of this study is to describe in detail the process of Empathic Communication Between Nurses and Elderly Patients at the Tresna Werdha Nursing Home, Kasihan, Bantul. The approach used by researchers is qualitative with descriptive type. The data collection technique used was in-depth interviews (in-depth interviews) and observation of nurse informants and the elderly. Retrieval of informants using sampling techniques purposive namely by setting the criteria of informants based on research needs. Nurse informants include those who have worked for at least 10 years, while elderly informants are over 60 years old and have been at the Tresna Werdha Bantul Nursing Home for at least 1 year. Based on the results of the study, shows that empathic communication has been carried out by nurses, namely by giving attention and care. The form of attention that nurses pay to elderly patients is by reminding them to take medicine, feed them, wash them, remind them to pray and understand sign language for the elderly. The forms of caring for nurses include being patient, respecting every word the elderly say, respecting and giving physical touch to elderly patients. However, in the process of empathic communication between nurses and elderly patients, there are several obstacles experienced by nurses, including unstable elderly emotions, misperceptions, and having to speak repeatedly. Efforts to overcome these obstacles are to create a calm atmosphere and serve wholeheartedly for the different conditions of the elderly.
Implementing Credit Agreement Restructuring During the COVID-19 Pandemic: A Case Study of PT. Bank Rakyat Indonesia (Persero) Tbk. Gombong Branch Office
Authors: Adyatma Rafid , Anggriani Reni
Published: February 2025

The spread of the COVID-19 Pandemic caused a decrease in income for debtors in bank credit agreements. This resulted in debtors experiencing difficulties in fulfilling their obligations. The government, through the Financial Services Authority (OJK), issued Financial Services Authority Regulation Number 11/POJK.03/2020 as a way to restructure credit agreements for debtors who are having difficulty paying as long as the spread of the COVID-19 pandemic causes this. PT. Bank Rakyat Indonesia, as one of the banks participating in implementing this policy, restructures credit agreements for its customers who have trouble fulfilling their credit obligations by applying an analysis based on the principle of prudence.
The Effect of Halal Labeling and Product Quality on Muslim Consumer Purchase Decisions on Safi Cosmetic Products with Brand Image as a Mediating Variable
Authors: Rahmawati Asanti Arum , Zakiy Muhammad
Published: February 2025

This study aims to determine the effect of halal labeling and product quality on Muslim consumers' purchasing decisions on Safi cosmetic products mediated by brand image. The current market competition related to cosmetic sales is very high, followed by the presence of many brands that release several products. Producers must have products that have their own charm that can increase consumer buying interest in making purchasing decisions. The sample in this study was Muslim female students in Yogyakarta who had purchased and used Safi products. The number of samples used amounted to 154 respondents. The method used to take samples is purposive sampling. This study uses primary data obtained from distributing online questionnaires via the Google form. The data obtained was analyzed using Smart PLS 3.0. The results of the study show that halal labeling and product quality have a positive effect on brand image. The study results also show that brand image has no effect on purchasing decisions. Brand image does not mediate the relationship between halal labeling and product quality on purchasing decisions. The results of this study can be a reference for Safi companies in improving aspects of halal labeling and product quality so as to create a good brand image for consumers in order to increase purchasing decisions.
Marketing Public Relations Activities in Building Local Media Brand Positioning in the Renewable Media Era
Authors: Indriastuti Dwi Cahyanti , Tunggali Ade Putranto Prasetyo Wijiharto
Published: February 2025

Public Relations in a company or institution can be achieved through Marketing Public Relations in order to achieve certain targets which previously had to have a clear and detailed work program. Marketing public relations is effective in building brand (product) awareness as well as brand knowledge. Marketing public relations is considered effective, the role of marketing public relations is needed to market a product or program with creative ideas. This study aims to find out about marketing public relations activities in building brand positioning using push, pull and pass strategies. In its development, in the digital era as it is today, many print media have gone out of business. One of the print media that has gone out of business (closed publication) is Republika, which will end at the end of 2022. Unlike Harian Jogja, which is still able to maintain its print media amidst the onslaught of technology. In more detail, the purpose of this study is to examine marketing public relations activities in building local media brand positioning in the era of renewable media. This research uses a qualitative approach, and Harian Jogja as the subject of study. Data collection techniques through observation, interviews and documentation. Marketing Public Relations activity is a step or method that every company takes in building a company's Brand Positioning. The Result for Marketing Public Relations activities have a very important role in making a brand progress and developing or the ability to market products and the superior quality of a company to the audience. One of the activities that can build the Harian Jogja Brand Positioning is the existing promotional programs and feedback from customers who always provide motivation and existing complaints. With the promotions, and feedback provided by Harian Jogja, it is able to give an attractive impression to customers through the strategies implemented.
The Effect of The Covid-19 Pandemic on MSMES In Yogyakarta City
Authors: Adhisena Muhammad , Wiranatakusuma Dimas Bagus , Kamil Muhamad
Published: February 2025

MSMEs are Micro, Small and Medium Enterprises that are usually carried out by the community to help their economy, not only that MSMEs also help the country's economy at the same time. However, currently MSMEs are in trouble because they are affected by Covid 19, so that it has an impact on the country's economy. This research uses a qualitative method, namely by conducting interviews with MSME actors. From the results obtained, it will provide answers about the impact of Covid 19 from each different MSME actor, because the impact of each seller will be different.
The Influence of Consumer Online Ratings and Reviews on Purchase Decisions on Tiktok Shop Marketplace Users
Authors: Sari Dewi Puspita , Era Agustina Yamini
Published: February 2025

Background: At this time shopping through the marketplace is a common thing, in addition to making it easy, consumers are also faced with many choices and a lot of different information from the seller. Consumers cannot touch and feel the product. This often raises doubts in the minds of consumers, so it takes effort to build consumer trust. Therefore, consumers try to obtain information through reviews and ratings available on various online platforms.  Objective: This study aims to examine the influence of consumer online ratings and reviews on purchasing decisions on Tiktok Shop marketplace users. Research Method: This research using the quantitative as the method with data collection techniques through the distribution of questionnaires to people in the Special Region of Yogyakarta who have made online transactions on the TikTok shop marketplace totaling 184 respondents. The sampling procedure used in this study was non-probability with purposive sampling technique.  Research Results: The results obtained after data analysis on Consumer Online Rating have a significant influence on purchasing decisions. Review has a significant positive influence on purchasing decisions. And simultaneously Consumer Online Ratings and Reviews have a positive and significant influence on purchasing decisions. This is in accordance with what was hypothesized.