bluuebunny/crossref_metadata_2025 huggingface dataset:
Globalization and music integration
Authors:   Teacher, Department of “Traditional Singing and Folk Instruments”, Faculty of Music Studies, Guliston State University, Uzbekistan, Tairjanovna Masharipova Gulbahor
Published: February 2025

This article is devoted to the study of the processes and consequences of musical integration in the context of globalization. The study analyzes how international socio-economic changes and digital technologies have affected musical culture, the interaction of regional musical traditions and modern styles. The article discusses musical innovations resulting from global trends, the widespread dissemination of music through new platforms, and the role of traditional music in this process. It also examines the positive and negative consequences of globalization on musical integration, the issues of cultural diversity and the preservation of national identity.
Fundamental Theoretical Aspects Of Didactic Competence In The Context Of The Educational Process
Authors:   Lecturer, Chirchik State Pedagogical University, Uzbekistan, Orazova F.O.
Published: February 2025

The article examines the importance of didactic competence in higher education, emphasizing its role in fostering students' creative thinking and enhancing education quality. Special focus is given to the competency-based approach, enabling the effective resolution of professional and pedagogical tasks. Key strategies for developing didactic competence include ICT integration, reflective practices, and project-based learning. The study highlights the significance of integrating knowledge, skills, and personal qualities to prepare students for independent professional activities.
Clinical Guidelines on Frailty
Authors: Tkacheva O. N. , Kotovskaya Yu. V. , Runikhina N. K. , Frolova E. V. , Naumov A. V. , Vorobyeva N. M. , Ostapenko V. S. , Mkhitaryan E. A. , Sharashkina N. V. , Tyuhmenev E. A. , Pereverzev A. P. , Dudinskaya E. N.
Published: February 2025

The paper introduces clinical guidelines on frailty that have been developed by the Russian Association of Gerontologists and Geriatricians. These guidelines are specifically designed to assist geriatricians, internists, general practitioners, family physicians, and other healthcare specialists who work with adult patients. Within the paper, there are screening instruments, diagnostic tools, and treatment options provided for individuals with frailty. Additionally, the paper also includes information on prevention, rehabilitation, and medical care organization for this cohort of patients.
İtfaiye Çalışanlarında Psikososyal Risk Etkenleri
Authors: Şavklı Yücel
Published: February 2025

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Contribución del emprendimiento social al desarrollo de las comunidades rurales del sureste mexicano
Authors: Chi-Tzeek Irvin Abimael , Barroso-Tanoira Francisco Gerardo , López-Ponce María Eugenia
Published: February 2025

Este estudio presenta una revisión teórica sobre la contribución del emprendimiento social al desarrollo de las comunidades rurales del sureste de México, específicamente en los estados de Campeche y Yucatán, comunidades marginadas que emplean el emprendimiento social como herramienta para el mejoramiento de sus condiciones de vida y de bienestar.
 
Abstract
This study presents a theoretical review of the contribution of social entrepreneurship to the development of rural communities in southeastern Mexico, specifically in the states of Campeche and Yucatán, marginalized communities that use social entrepreneurship as a tool for the improvement of their living conditions and well-being
Universidades y ODS: repensando la sostenibilidad a través de teorías organizativas y marcos globales
Authors: Oliva Carina Dolores , Beltran Natacha
Published: February 2025

Este estudio explora cómo teorías organizativas justifican conceptualmente la integración de los ODS en universidades, identificando marcos como SDSN y PRME. Basado en revisiones de literatura científica, analiza enfoques teóricos predominantes para guiar la integración sostenible, resaltando limitaciones y su utilidad para investigadores y gestores en el contexto universitario.
 
Abstract
This study explores how organizational theories conceptually justify the integration of SDGs into universities, identifying frameworks such as SDSN and PRME. Based on a review of scientific literature, it analyzes predominant theoretical approaches to guide sustainable integration, highlighting limitations and its relevance for researchers and managers in the university context.
INTERNALIZATION OF THE PANCASILA STUDENT PROFILE IN SHAPING THE CHARACTER OF CLASS VA STUDENTS AT UPTD SD INPRES LILIBA KUPANG CITY
Authors: Lado Windyantri M , Nitte Yulsy M. , Naitili Cornelia A.
Published: February 2025

This research aims to describe the internalization of the Pancasila Student Profile in shaping the character of Class VA students at UPTD SD Inpres Liliba, Kupang City. The research method used is qualitative descriptive. The research focuses on the application of six dimensions of the Pancasila Student Profile: faith and devotion to the Almighty God along with noble character, global diversity, cooperation, independence, critical reasoning, and creativity. Data collection techniques included interviews, observations, and documentation. Primary data were obtained from respondents, while secondary data were sourced from theories, journals, and related school documents.
The research concluded that character values based on the Pancasila Student Profile have been successfully internalized in shaping the character of Class VA students at UPTD SD Inpres Liliba, Kupang City. This was achieved through the implementation of Pancasila values in curricular, extracurricular, and school cultural activities. Despite challenges such as limited teacher understanding, lack of facilities, and minimal collaboration with parents, efforts like teacher training, the use of learning media, and cooperation with parents effectively improved the internalization of Pancasila values. As a result, students demonstrated character traits aligned with Pancasila values, such as cooperation and independence. This initiative aims to create a generation with strong character aligned with Pancasila values.
THE ROLE OF THE TEACHER IN DEVELOPING STUDENTS' LEARNING CREATIVITY IN CIVIC EDUCATION LEARNING AT GMIT KUANINO I ELEMENTARY SCHOOL
Authors: Liunesi Rosita , Mbuik Heryon B. , Naitili Cornelia A. , Nitte Yulsy M.
Published: February 2025

The teacher’s role in reminding students of their learning creativity is one of the integral activities that must be included in learning activities. Apart from providing and transferring knowledge, teacher’s are also tasked with increasing children’s creativity in learning. The learning process will be successful if student’s have motivation and creativity in learning. The aim of this research is to find out the role of teachers in developing student learning creativity. This research uses qualitative research, using a descriptive approach, because this research is used to describe and analyse teacher’s efforts to increase student learning motivation in PKN learning to imprive srudent learning achievement at GMIT Kuanino 1 elementary school. The teacher’s efforts to develop student’s learning creativity in class IV citizenship education at SD GMIT Kuanino 1 is to obtain additional learning resources usung the internet. This is done so that student’s and learn develop their creativity well in participating in citizenship education lessons.
AGENDA OF CULTIVARS AND THE REDUCTION OF PESTICIDE USE IN BRAZIL
Authors: Andrade Fábio de , Menezes Júnior Eumar Evangelista de
Published: February 2025

The present work presents an important part of the 'State of the Art' scheduled for the preparation of a Master's Thesis being developed in the stricto sensu Graduate Program in Environmental Sciences at the Evangelical University of Goiás (UniEVANGÉLICA). The agenda highlights the importance of studying/employing cultivars for the reduction of pesticide use in Brazil. To achieve success, a deductive approach was employed, enhanced by bibliographic and documentary techniques, which allowed for the development of descriptive research.
SCOUT EDUCATIONAL METHOD AND TRANSDISCIPLINARITY: CONTRIBUTIONS TO ENVIRONMENTAL EDUCATION
Authors: Sobreira Patrí­cia de Alburquerque , Rosseto Lucimar Pinheiro
Published: February 2025

Founded by Baden-Powell, scouting, being non-formal education, allows its members to value the environment, preparing them for preservation and sustainable development. In this study, the practice of scouting and its socio-environmental and educational benefits for children and adolescents of the Bernardo Sayão Scout Group were analyzed through the Reduce, Recycle, and Reuse (3R's) badge activity. Bibliographic and field research was conducted, with a qualitative approach. The theoretical framework was based on the concepts of Scouting, Environmental Education, Non-formal Education, and Transdisciplinary Education. Technical visits were conducted weekly to the Scout Group from October to November 2022. For four months, the scouts collected PET bottle caps and participated in workshops. With the guidance of a Scout Leader, they crafted with the bottle caps: tic-tac-toe, pencil holder, fidget spinner, cup and plate holder. The scouts evaluated the discarded material regarding the environment and realized the importance of responsible consumption and the reuse of bottle caps. This research demonstrated that the scouting method is a transdisciplinary education that cares about and carries out activities related to environmental and sustainability issues, such as the 3R's Badge, promoting sustainable habits for an ecological and healthy lifestyle.
Implementation of Kepmen ESDM No 1827 K/30/MEM/2018 Concerning Guidelines for the Implementation of Good Mining Techniques for the Utilization of Coal Post-Mining Reclamation in the Form of Tourism
Authors: Meily Putri Amelia  , Suhadi  , Pujiono
Published: February 2025

Indonesia's natural resource wealth has been recognized by the world since the colonial period, one of its natural wealth is mineral resources. The abundance of mineral mining goods in Indonesia creates another urgency regarding the final production results from mining, namely mine excavation holes. The solution offered by the government is reclamation in the form of other forms of utilization, one of which is tourism. This solution was realized with Minister of Energy and Mineral Resources Decree No. 1827 K/30/MEM/2018 concerning guidelines for good mining engineering principles. The use of reclamation as a form of tourism has had an impact on the environment, social and economy, for example the AirANGKAng Tourism Village where tourist attractions include fisheries, animal husbandry, water tourism, and animal conservation, the Breksi Cliff Tourism in Jogjakarta, then the Lati Petangis Grand Forest Park in Paser where it is used as a means of water tourism, flora and fauna conservation, and is used for deer farming.
Động lực làm việc của điều dưỡng lâm sàng tại bệnh viện đại học Y Dược Shing Mark Đồng Nai năm 2022 và một số yếu tố ảnh hưởng
Authors:   Hanoi University of Public Health, Vo Tuan Ngoc , Nguyen Duy Tien ,   Hanoi University of Public Health
Published: February 2025

Objectives: This study has two objectives as the follows: to describe the motivations of clinical nursing and determine factors influencing motivation of clinical nurses in University Medical Shing Mark hospital of Dong Nai in 2022. Methods: This is a cross-sectional descriptive study, combining quantitative and qualitative method. Quantitative data was conducted via self-administered questionnaire among 198 clinical nurses. Qualitative data was collected from 04 in-dept interviews and 01 focus groups discussion. Main findings: The average working motivation score of clinical nurses in the University Medical Shing Mark hospital of Dong Nai: 3,95/5, the proportion of clinical nurses being motivated is 57,58 %. Commitment and dedication to work have motivational rates (70.20% and 63.13%). The component of job satisfaction (57.58%). Factors influencing the motivation of nurses: Personal factors: There is a correlation between the motivation of nurses and age group, number of dependents, length of service, number of shifts per month, and main income. Positive factors: Income and benefits, working conditions, training and development, relationships at work. Negative factors are management and administration.
Key words: Motivation, influenced factor, University Medical Shing Mark hospital of Dong Nai
Donatello’s pulpits from the Basilica of San Lorenzo in Florence and bronze sculptures from Siena’s baptistery font: technical findings from recent conservation projects
Authors: Baruffetti Maria , Agnoletti Stefania , Brini Annalena , Pacini Alessandro , Pucci Elisa , Speranza Laura
Published: February 2025

This article offers new insights into the conservation of two important works by Donatello: the bronze pulpits in the Basilica of San Lorenzo in Florence and the baptismal font in the Baptistery of San Giovanni in Siena. The study, carried out by the Opificio delle Pietre Dure (under the Italian Ministry of Cultural Heritage), highlights the meticulous assessment of these works of art. The authors focus on the state of conservation and the phenomena of deterioration, but above all on the techniques used by Donatello and his assistants to complete the bronze figures and panels. The restoration of the pulpits, from 2011 to 2017, provides an insight into the complex processes of assembly and casting. Close observation, supported by analysis, reveals various joining techniques, including iron rods and mechanical joints, as well as casting flaws and evidence of Donatello’s craftsmanship. Similarly, the recently completed restoration of the Siena baptismal font involved dismantling the bronze elements for cleaning and analysis, leading to discoveries about the original mounting systems and casting techniques used by Donatello and others. The project identified patterns of deterioration as well as material composition, improving our understanding of the artworks’ historical context. Overall, this research not only sheds light on Donatello’s innovative sculptural practices in the two case studies, but also seeks to contribute to broader knowledge of the Renaissance bronze-casting solutions used by Donatello and his contemporaries.
The Membership and Age of the Planet-hosting Young Star IRAS 04125+2902*
Authors: Luhman K. L.
Published: February 2025

A transiting planet was recently discovered around a star in the Taurus star-forming region, IRAS 04125+2902, making it one of the youngest known planets. The discovery paper cited two age estimates for IRAS 04125+2902, one based on a comparison to two sets of model isochrones in the Hertzsprung–Russell diagram and a second age reported by an earlier study for a putative population in Taurus that includes IRAS 04125+2902 (D4-North). However, the model isochrones in question differ significantly for most temperatures and luminosities of young low-mass stars, and do not reproduce the observed sequences for the TW Hya and 32 Ori associations (10 and 21 Myr). Meanwhile, as found in my previous work, D4-North is a collection of field stars and fragments of several distinct Taurus groups and older associations, so its quoted age is not meaningful. The true parent population for IRAS 04125+2902 is a small group that is ∼35 pc behind the L1495 and B209 clouds (B209N). I have analyzed the age of B209N through a comparison to TW Hya and 32 Ori. The M-star sequences in the latter two associations have the same shapes, but the sequence for B209N is flatter, indicating that >M4 stars at ages of <10 Myr fade more quickly than stars at earlier types and older ages. For the one member of B209N that is earlier than M4 (IRAS 04125+2902), I estimate an age of 3.0 ± 0.4 Myr based on its offsets from TW Hya and 32 Ori, which by happenstance is similar to the value derived through the comparison to model isochrones.
Long-term X-Ray Variability on the Benchmark YSO HL Tau
Authors: Silverberg Steven M. , Wolk Scott J. , Principe David A. , Schneider P. C. , Günther Hans Moritz , Kim Jinyoung Serena , Kastner Joel H.
Published: February 2025

HL Tau is one of the most well-studied Class I young stellar objects (YSOs), including frequent observations at near- and mid-infrared, (sub)millimeter, and X-ray wavelengths. We present the results of an X-ray variability monitoring campaign with XMM-Newton in 2020 and X-ray grating spectroscopy from Chandra/HETGS in 2018. We find that the X-ray spectrum of HL Tau is consistently hot (with characteristic plasma temperatures T ≳ 30 MK) over 31 epochs spanning 20 yr, which is consistent in temperature with most Class I YSOs. The high-resolution HETG spectrum indicates the presence of some cooler plasma. We characterize the variability of the star across the 31 observations and find a subset of observations with significant variability on a ∼21-day timescale in the observed count rate and flux. We discuss the possible origins of this variability and identify further observations that would better constrain the nature of the changes.
Empirical Constraints on Tidal Dissipation in Exoplanet Host Stars
Authors: Millholland Sarah C. , MacLeod Morgan , Xiao Felicia
Published: February 2025

The orbits of short-period exoplanets are sculpted by tidal dissipation. However, the mechanisms and associated efficiencies of these tidal interactions are poorly constrained. We present robust constraints on the tidal quality factors of short-period exoplanetary host stars through the usage of a novel empirical technique. The method is based on analyzing structures in the population-level distribution of tidal decay times, defined as the time remaining before a planet spirals into its host star due to stellar tides. Using simple synthetic planet population simulations and analytic theory, we show that there exists a steady-state portion of the decay time distribution with an approximately power-law form. This steady-state feature is clearly evident in the decay time distribution of the observed short-period planet population. We use this to constrain both the magnitude and frequency dependence of the stellar tidal quality factor and show that it must decrease sharply with planetary orbital period. Specifically, with

Q
′
=

Q
0

(
P
/
2

days
)

α

, we find 105.5 ≲ Q
0 ≲ 107 and −4.33 ≲ α ≲ −2. Our results are most consistent with predictions from tidal resonance locking, in which the planets are locked into resonance with a tidally excited gravity mode in their host stars.
Simulating the Arrival of Multiple Coronal Mass Ejections That Triggered the Gannon Superstorm on 2024 May 10
Authors: Thampi Smitha V. , Bhaskar Ankush , Mayank Prateek , Vaidya Bhargav , Venugopal Indu
Published: February 2025

The 2024 May 10 space weather event stands out as the most powerful storm recorded during the current solar cycle. This study employs a numerical framework utilizing a semiempirical coronal model, along with heliospheric upwind extrapolation with time dependence and cone coronal mass ejection (CME) models for the inner heliosphere, to forecast solar wind velocity and the arrival of CMEs associated with this event. The simulations were also carried out using the Space Weather Adaptive Simulation framework and a drag-based model (DBM) for this complex event of multiple CMEs. Predicted arrival times and velocities from these models are compared with actual observations at the Sun–Earth L1 point. These simulations reveal that three CMEs reached Earth nearly simultaneously, resulting in the extreme space weather event, followed by the arrival of a few more eruptions. The simulations accurately predicted arrival times with a discrepancy of approximately 5 hr or less for these CMEs. Further, the ensemble study of the DBM shows the sensitivity of the CME arrival time to the background solar wind speed and drag parameters. All three models have done fairly well in reproducing the arrival time closely to the actual observation of the CMEs responsible for the extreme geomagnetic storm of 2024 May 10. These rare solar storms offered a unique opportunity to thoroughly evaluate and validate our advanced models for predicting their arrival at Earth.
Dynamic Photometric Variability in Three Young Brown Dwarfs in Taurus: Detection of Optical Flares with TESS Data
Authors: Ghosh Samrat , Mondal Soumen , Dutta Somnath , Kumbhakar Rajib , Das Ramkrishna , Joshi Santosh , Lata Sneh
Published: February 2025

We present I-band time-series photometric variability studies of three known nearby (∼140 pc) and young (∼1 Myr) brown dwarfs (BD) in the Taurus star-forming region in the Perseus molecular cloud. From 10 nights of observations over a time span of 10 yr, with a typical run of 3–6 hr each night, we estimated that the BDs show unstable short-scale periodicity from 1.5 to 4.8 hr. Using the long-term photometry from the Transiting Exoplanet Survey Satellite (TESS), we have conducted a time-resolved variability analysis of CFHT-BD-Tau 3 and CFHT-BD-Tau 4, revealing orbital periods of ∼0.96 days and ∼3 days respectively, consistent with earlier studies. We also found two superflares in TESS sector 43 data for CFHT-BD-Tau 4 and estimated the flare energies as 7.09 × 1035 erg and 3.75 × 1036 erg. A magnetic field of ∼3.39 kG is required to generate such flare energies on this BD. We performed spot modeling analysis on CFHT-BD-Tau 3 and CFHT-BD-Tau 4 to address the variability detected in the data using the package BASSMAN. Spectral energy distribution and infrared colors of the sources suggest that they have a sufficient amount of circumstellar material around them.
MAMMOTH-Subaru. IV. Large Scale Structure and Clustering Analysis of Lyα Emitters and Lyα Blobs at z = 2.2–2.3
Authors: Zhang Haibin , Cai Zheng , Li Mingyu , Liang Yongming , Kashikawa Nobunari , Ma Ke , Wu Yunjing , Li Qiong , Johnson Sean D. , Kikuta Satoshi , Ouchi Masami , Fan Xiaohui , Ning Yuanhang
Published: February 2025

We report the large scale structure and clustering analysis of Lyα emitters (LAEs) and Lyα blobs (LABs) at z = 2.2–2.3. Using 3341 LAEs, 117 LABs, and 58 bright (Lyα luminosity L
Lyα
 > 1043.4 erg s−1) LABs at z = 2.2–2.3 selected with Subaru/Hyper Suprime-Cam, we calculate the LAE overdensity to investigate the large scale structure at z = 2. We show that 79% of LABs and 83% of bright LABs are located in overdense regions, which is consistent with the trend found by previous studies that LABs are generally located in overdense regions. We find that one of our eight fields, dubbed J1349, contains 39/117 ≈ 33% of our LABs and 22/58 ≈ 38% of our bright LABs. A unique and overdense

2

4

′

×
1

2

′

(40 × 20 comoving Mpc2) region (J1347 protocluster) has 12 LABs (eight bright LABs). By comparing to SSA22, which is one of the most overdense LAB regions found by previous studies, we show that the J1347 protocluster region has a higher bright LAB density than the SSA22 protocluster region with a 1σ significance. We calculate the angular correlation functions (ACFs) of LAEs and LABs in the unique J1349 field and fit the ACFs with a power-law function to measure the slopes. The bright LABs show a 5σ larger slope, suggesting that bright LABs are more clustered than faint LAEs. Our LABs have a large galaxy bias of ∼5–7, which suggests that LABs generally reside in more massive dark matter halos (halo masses M ≳ 1013
M
⊙) than faint LAEs.
Pseudo-Newtonian Simulation of a Thin Accretion Disk Around a Reissner–Nordström Naked Singularity
Authors: Čemeljić Miljenko , Kluźniak Włodek , Mishra Ruchi , Wielgus Maciek
Published: February 2025

We present the first numerical simulations of a thin accretion disk around a Reissner–Nordström (RN) naked singularity (NkS; a charged point mass). The gravity of the RN NkS is modeled with a pseudo-Newtonian potential that reproduces exactly the radial dependence of the RN Keplerian orbital frequency; in particular, orbital angular velocity vanishes at the zero gravity radius and has a maximum at 4/3 of that radius. Angular momentum is transported outward by viscous stresses only outside the location of this maximum. Nonetheless, even at that radius, accretion proceeds at higher latitudes, the disk having thickened there owing to excess pressure. The accretion stops at a certain distance away from the singularity, with the material accumulating in a toroidal structure close to the zero-gravity sphere. The shape of the structure obtained in our simulations is reminiscent of fluid figures of equilibrium analytically derived in full general relativity for the RN singularity. The presence of a rotating ring, such as the one found in our simulations, could be an observational signature of an NkS. For charge-to-mass ratios close to but larger than unity, the inner edge of the quasi-toroidal inner accretion structure would be located well within the Schwarzschild marginally stable orbit (ISCO), and the maximum orbital frequency in thin accretion disks would be much higher than the Schwarzschild ISCO frequency.
The Error Estimation of Transverse Coronal Loop Oscillation Parameters Based on Least Chi-squares Fitting
Authors: Li Hongbo , Feng Hengqiang , Tian Zhanjun , Cai Qiangwei , Zhao Guoqing , Zhao Yan
Published: February 2025

Transverse oscillations of coronal loops not only influence coronal dynamics, but also provide a new perspective for coronal detection. To enhance their exploitation and utilization, accurately estimating the oscillation parameters is crucial. The least chi-squares fitting is a widely employed method for this estimation. However, due to the highly nonlinear nature of the fitting process, there is no established theory to provide the exact error of the fitted parameters. In this study, we systematically investigated the accuracy and precision of the fitted parameters of transverse coronal oscillations through a series of forward simulations. Our investigation indicates that the accuracy and precision of fitted oscillation parameters are influenced not only by the standard deviation of the measurement error, but also by the temporal resolution and the characteristics of the signal itself. Based on these findings, we conducted additional forward simulations to estimate the influences on the real observation examples. The results clearly show that (1) the fitted damping timescale should be overestimated in a significant number of transverse coronal loop oscillations, and (2) errors estimated by the general method may be biased. In response, we have developed a forward simulation-based schema to achieve a self-consistent error estimation for the fitted oscillation parameters. These contributions not only offer valuable insights into the error estimation of fitted transverse coronal oscillation parameters, but also establish a robust foundation for obtaining accurate and precise transverse oscillation parameters of the corona.
Effects of capecitabine chemotherapy on the expression of CASC18, CASC19, and CASC20 lncRNAs in patients with colorectal cancer and the HCT-116 colorectal cancer cell line
Authors: Chayd Nafea M. , Khalaj-Kondori Mohammad , Safaralizadeh Reza , Hosseinpour Feizi Mohammad Ali
Published: February 2025

Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths. Capecitabine is a key chemotherapy drug for colorectal cancer (CRC). Long non-coding RNAs (lncRNAs) play a role in the pathogenic pathways associated with colorectal cancer. This investigation compared the expression patterns of CASC18, CASC19, and CASC20 in CRC patients before and after chemotherapy, as well as in healthy individuals. The effects of capecitabine on cell viability, apoptosis, cell cycle, and the expressions of CASC18, CASC19, and CASC20 were examined using HCT-116 cells.

Methods: CASC18, CASC19, and CASC20 expressions were assessed using qRT-PCR on patients’ and healthy tissues. Furthermore, the receiver operating characteristic (ROC) curve analysis was used to evaluate the prognostic and diagnostic value of CASC18, CASC19, and CASC20 in CRC. The MTT test was used to assess capecitabine’s cytotoxicity on the HCT-116 CRC cell line. Annexin-V/PI staining was used to examine apoptosis and cell cycle progression by flow cytometry. Gene expression differences between before and after capecitabine treatments were examined by qRT-PCR.

Results: Results showed that patients with colorectal cancer had lower levels of CASC18 but higher levels of CASC19 and CASC20 expression than the healthy group. Moreover, patients treated with capecitabine showed an increased CASC18 expression, while non-significant changes were observed in the expression of CASC19 and CASC20. The clinical factors were not associated with the expression of lncRNAsCASC18, CASC19, and CASC20. Furthermore, results indicated that CASC18, CASC19, and CASC20 are poor biomarkers for diagnosis of CRC. MTT analysis revealed a dose- and time-dependent cytotoxic effect for capecitabine on the HCT-116 cells. Capecitabine treatment led to the accumulation of the HCT-116 cells in the Sub-G1 phase, suggesting an apoptotic solid impact on the cells. Moreover, HCT-116 cells were arrested in the G2/M phases by capecitabine. Capecitabine also upregulated CASC18 expression in the HCT-116 cell line.

Conclusion: These results support the anticancer and cytotoxic effects of capecitabine and highlight its ability to increase CASC18 expression. Additionally, the findings indicate that CASC18, CASC19, and CASC20 are poor biomarkers for colorectal cancer (CRC) diagnosis.
Le pouvoir normatif des fonctionnaires. L’exemple de la création du régime d’enregistrement des installations classées pour la protection de l’environnement
Authors: Martinais Emmanuel , Bonnaud Laure
Published: February 2025

Cet article a pour objectif l’analyse de l’activité administrative d’écriture des lois et règlements en s’appuyant sur la littérature en sciences sociales envisageant la production du droit comme une œuvre collective. En prenant pour exemple les textes instaurant un régime d’autorisation simplifié pour les installations industrielles dangereuses ou polluantes, cela permet de caractériser le travail des fonctionnaires dans ce processus d’écriture, et de montrer que leur activité va au-delà de la simple formulation des problèmes, souvent décrite dans la littérature . Les fonctionnaires interviennent en effet en séquençant le processus d’écriture et en délimitant des espaces pertinents, dans lesquels ils sélectionnent et coordonnent les interlocuteurs qui contribuent à l’activité rédactionnelle.
“Le Printemps” d’Agrippa d’Aubigné, un “Printemps” charnel
Authors: Lestringant Frank
Published: February 2025

Here we focus on two poems from Le Printemps in the Droz edition, Ode XXIV, «Que je te plains, beauté divine!» opposing old and young, ugly and beautiful woman, and the Mélanges, XVI, «Encor’ le Ciel cruel…», announcing an episode in Les Fers, the fifth book of the Tragiques. While in Ode XXIV the female sex is forbidden, when it happens to be desirable, piece XVI of the Mélanges contains the beginnings of the Tragiques knot, when the wounded poet rushes to his death «recueilli à Talcy, sur une table, seul». In composing these two long pieces, and in the intertwining of anterotics and juvenile love, Agrippa d’Aubigné was preparing the vast laboratory of the Tragiques.
Une poétique de la «folle fantaisie». L’ode XXXVII du “Printemps” au miroir des “Hymnes des saisons” de Ronsard
Authors: Vintenon Alice
Published: February 2025

This article examines the ode XXXVII of the Printemps, showing that it reflects a close reading of Ronsard’s Saisons, as well as a desire to distinguish himself from Ronsard’s poetic choices. After highlighting the narrative similarities between the ode and Ronsard’s cycle, Alice Vintenon points out that, as in the ode XIV, d’Aubigné does not adopt the reference to inspired, learned poetry asserted in the prologues of the Saisons, but instead, discreetly paraphrasing Horace, claims total freedom for poetic fantasy. In so doing, he sets himself apart from the spirit of seriousness that characterized the philosophical poetry of his time (like Du Bartas’ Sepmaine).
Des Œillets lusotropicalistes ?
Authors: Cahen Michel
Published: February 2025

Il est facile de constater que le lusotropicalisme a survécu à la Révolution des Œillets. Cela induit deux questions. Premièrement, les manifestations de lusotropicalisme ont-elles été nombreuses dans le cours même de la révolution, en particulier parmi les militaires ? Deuxièmement, est-ce à cause des caractéristiques propres à la révolution que le lusotropicalisme aurait si bien survécu ? Cet article cherche à répondre à ces questions en analysant des textes, des déclarations, des actes de responsables politiques et militaires portugais dans les années postérieures à la Révolution des Œillets, jusqu’en 2024. Il cherche ensuite le même genre de comportement pendant la révolution elle-même. La conclusion est mitigée : oui, il existe un lusotropicalisme systémique au Portugal mais cela ne veut pas dire qu’il soit hégémonique. Par ailleurs, il est difficile de distinguer le lusotropicalisme de la vieille idéologie impériale du Portugal.
Descolonização do Timor-Leste: desdobramentos da Revolução dos Cravos na colônia mais longínqua (1974-1975)
Authors: Paredes Marçal de Menezes , Magnus Bianca Obetine
Published: February 2025

A Revolução dos Cravos não se resume ao cenário português. Há toda uma história global que se desdobra à montante e à jusante do golpe do 25 de Abril de 1974. A guerra anticolonial e os processos de independência e transferência de poder nas ex-colônias na África e na Ásia são apenas algumas facetas deste processo. O trabalho político diplomático dos movimentos de libertação neste processo é outro ponto de elevada importância. Este artigo dá particular atenção ao turbilhão político que emerge da Revolução dos Cravos, que possuiu fortes articulações no ambito global da Guerra Fria. Discute-se o caso do Timor-Leste, a mais longínqua colônia portuguesa no sudeste asiático, como um cenário de exemplo das influêcias políticas oriundas do contexto português. Este artigo coloca em perspectiva as redes e as conexões globais existentes no processo da Revolução dos Cravos e de descolonização do Timor-Leste entre 1974 e 1975.
La influencia de la revolución portuguesa en la prensa progresista regional española. El caso de Andalán (1972-1976)
Authors: Ramos Antón Rubén
Published: February 2025

Este artículo analiza la influencia que ejerció la revolución portuguesa (1974-1975) en Andalán, una revista impulsada durante la transición política española por parte de sectores intelectuales de izquierda y autonomistas en Aragón. A través del estudio de caso, se analizan las publicaciones que abordaron directamente la cuestión o que contenían referencias a este proceso político. Los resultados demuestran que los acontecimientos desencadenados por el 25 de abril de 1974 fueron un referente para la prensa democrática española, también a nivel regional, y que esta revista manifestó un apoyo explícito a los sectores más progresistas de cuantos protagonizaron la revolución.
Visions de l’animal chez Giacomo Leopardi
Authors: Pignataro Agnese
Published: February 2025

Cet article vise à interroger les différentes visions de l’animal propre à Giacomo Leopardi. Il entend notamment approfondir la question de la condition commune entre les êtres humains et les animaux. La pensée de Leopardi pose d’abord un écart entre l’homme et l’animal qui explique tant le malheur du premier, éloigné de sa condition naturelle, que le bonheur dont jouit le second. Nous montrons qu’au fil de l’évolution du système philosophique de Leopardi, ce thème perd progressivement de son importance et donne le relais à l’idée d’un état de souffrance inhérent à tous les êtres sensibles, humains et non humains. Dans cette seconde vision de l’animal, celui‑ci est au même titre que l’homme la victime de la cruelle indifférence de la nature. L’œuvre de Leopardi présente de nombreux exemples de la précarité de la vie animale, notamment du fait de la prédation, un mal ordinaire nécessaire au fonctionnement du cycle naturel de production/destruction. Cette idée d’une communauté de destin entre les humains et les autres animaux trouve son développement ultime dans l’esquisse léopardienne d’une alliance zoo‑anthropologique, dont nous approfondissons les sources et l’interprétation.
Leopardi à l’heure de l’Anthropocène
Authors: Lanfranchi Stéphanie
Published: February 2025

Poser la question de Leopardi à l’heure de l’Anthropocène, interroger la pertinence d’une relecture de son œuvre à l’aune d’un débat, d’événements et d’une terminologie qui lui sont largement postérieurs, entraîne, du point de vue critique, de réelles difficultés méthodologiques et herméneutiques. S’agit‑il d’une énième actualisation de l’œuvre de Leopardi, comme l’histoire de sa réception et de sa fortune n’a cessé de nous en offrir durant les deux derniers siècles ? Dans cette contribution, nous aborderons d’abord les écueils méthodologiques auxquels se confronte inéluctablement une éco‑critique de Leopardi qui chercherait en lui un précurseur ou un visionnaire des apories écologiques de notre siècle. Nous tenterons ensuite d’inscrire notre interrogation à l’intérieur d’un cadre culturel, idéologique et géologique, qui intègre les questionnements actuels autour de l’Anthropocène dans les temps longs de l’histoire européenne occidentale, remontant jusqu’aux Lumières et à la révolution industrielle. Plutôt que d’actualiser la pensée de Leopardi, nous proposons ainsi une distant reading, diachronique et panoramique, susceptible d’historiciser le discours de l’Anthropocène en retraçant ses origines, pour voir dans quelle mesure Leopardi avait quelque chose à dire, dès le xixe siècle, sur et contre les mythes fondateurs de cet Anthropocène qui ne portait pas encore son nom.
Wine Tourism Meets the Metaverse
Authors: Barbosa Belem , Singh Shalini , Yetik Tuğçe , Carvalho Camila
Published: February 2025

Technological developments are presenting new ways for companies to organize their businesses and offer new products, services, and experiences to their customers. The Metaverse allows the participation and interaction of individuals in immersive experiences that merge virtual and real worlds. The adoption of metaverse platforms by companies worldwide is growing steadily, with the potential to change business in various industries, including tourism. However, the literature on the Metaverse applied to tourism is very scarce. This chapter addresses this gap by exploring a case study of the implementation of a Metaverse strategy by a Portuguese wine brand, Sandeman, as part of their wine tourism experience offerings. The case study is built on secondary data, observation, and interviews with tourists.
Analysis of the Impact of Metaverse on the Retailer's Brand Perceptions
Authors: Pratas Joaquim Monteiro , Moreira Gabriel Dias , Garcez João Guilherme , Simões Ivan , Neves Andrade Leonardo Roberto , Martins João Miguel Da Silva
Published: February 2025

Retailers are increasingly exploring new communication and sales channels, with the metaverse offering a promising opportunity. This study examines how Nike's presence in the metaverse, through Nikeland, impacts brand image and consumer expectations. Factors analyzed include respondent characteristics, metaverse knowledge and usage, valued Nike attributes, customer loyalty, and product quality perceptions. Data was collected with a survey of 401 respondents. Analysis using structural equation modeling revealed that most respondents view Nike's metaverse presence as enhancing its innovative image, overall brand perception, brand awareness, and brand equity. Key consumer expectations for the metaverse store include attractive decoration, product quality, pleasant atmosphere, and a quality consumer experience. The study highlights the significant relationship between brand image and consumer expectations, providing strategic insights for retailers on target definition and refining metaverse experiences.
Artificial Intelligence for Predicting Progression and Personalizing Healthcare to Alzheimer's Disease Patients
Authors: Ali Imreena , Manda Vijaya Kittu
Published: February 2025

This chapter explains the use of Deep Learning Models from Artificial Intelligence (AI) that take Structural and Functional Magnetic Resonance Imaging (S/FMRI) data to classify Alzheimer's disease (AD) progression stages. Early and accurate diagnosis of AD is necessary for timely intervention, treatment planning, and providing personalized healthcare. Current limitations in diagnostic methods necessitate using AI methods such as Convolutional Neural Networks (CNN) and Recurrent Neural Networks (RNN) to extract features from MRI data and develop models for predicting Mild Cognitive Impairment (MCI), AD, and Dementia. Initial results from a case study that applied the methodology demonstrated improved classification accuracy over traditional methods in accurately classifying disease stages and developing patient care. With more refinement as AI technologies progress, these computational approaches can drastically and positively change patient care. Healthcare professionals benefit from this chapter by understanding how AI can be implemented to deal with neurodegenerative diseases.
Paying for Online Interactive Sex Addiction
Authors: Uludag Kadir
Published: February 2025

With the increasing availability of online sexual content and the ease of access to online sexual services, individuals may develop patterns of behavior that reflect compulsive or addictive sexual behavior. One such pattern is online interactive sex addiction, which involves paying for sexual services provided by another person via the internet. This chapter explores the theoretical basis for patterns of online interactive sex addiction. The goal of the study was to define online interactive sex addiction that includes buying online sexual services impulsively.
Revolutionizing Rural Development
Authors: Tamrakar Anand , Yadav K. P.
Published: February 2025

The integration of artificial intelligence (AI) with Mobile-GIS is revolutionizing rural development in Chhattisgarh by providing innovative solutions across agriculture, healthcare, education, and resource management sectors. Predictive analytics for smarter agriculture, environmental sustainability, and better decision-making are just some of the ways in which AI-powered cognitive systems are making a difference. The companies have been offering technology such as Mobile-GIS, accurate mapping, real-time monitoring to deploy effective resource allocation and disaster management. These technologies, used in unison, can give rural communities data-driven insights and tools to enhance livelihoods and quality of life. Early implementations in Chhattisgarh show promise, with greater agricultural productivity and public service delivery streamlined if data is shared freely. Combining AI and GIS can help Chhattisgarh evolve into a model of future-ready, inclusive, efficient, sustainable rural development.
Evolutionary Neural Network-Based Online Ecological Governance Monitoring of Industrial Water Pollution
Authors: Zhao Ying
Published: February 2025

This paper proposes ENNOEIGS, an evolutionary neural network-based online ecological industrial governance system that integrates advanced neural architectures with evolutionary optimization for robust pollution monitoring. The framework combines convolutional neural networks for dimensional reduction of sensor data, external attention mechanisms for discovering pollution pattern correlations, and convolutional long short-term memory networks for modeling the spatiotemporal evolution of contaminants. A genetic algorithm continuously optimizes the neural network parameters, enabling adaptation to changing industrial conditions. Experimental validation using industrial wastewater monitoring data demonstrates ENNOEIGS's superior performance, achieving a 94.8% anomaly detection rate with 2.3% false alarms, outperforming existing approaches. The framework reduces the mean modified absolute error to 0.028 mg/L while maintaining faster convergence during training.
Real-life effectiveness of narrowband UVB phototherapy for pityriasis lichenoides: a retrospective study
Authors: Bardelli Rachele , Bellinato Francesco , Carugno Andrea , Zerbinati Nicola , Gisondi Paolo , Girolomoni Giampiero
Published: February 2025

Dear Editor,
Pityriasis lichenoides (PL) is an inflammatory skin disease of unknown etiology. The clinical spectrum of pityriasis lichenoides encompasses febrile ulcer-necrotic Mucha-Habermann disease (FUMHD), pityriasis lichenoides et varioliformis acuta (PLEVA), and pityriasis lichenoides chronica (PLC). Phototherapy is an effective and well-tolerated modality that is often successful for persistent PL or resistant to topical treatments. A retrospective observational study was conducted involving patients from the dermatology section of the University of Verona with a confirmed histological diagnosis of PLEVA and PLC accessed between January 2003 and June 2024. [...]
Cartographies of difference: Race, gender and dis-eased humanity in Mphuthumi Ntabeni’s The Wanderers
Authors: Mavengano Esther
Published: February 2025

The treatment of space in Mphuthumi Ntabeni’s novel The Wanderers provides important prisms through which the interlocking issues of race, gender and human frailties can be investigated. In this study, I bring together Michel Foucault and Doreen Massey’s perceptive formulations of spatiality and power to interrogate how Ntabeni’s representation of space intersects with the troubling tropes of racialised, gendered and dis-eased bodies in post-apartheid South Africa. I argue that the analogues of the frail human body and sickness are compelling symbolic figurations of dis-eased and broken people in South Africa’s post-apartheid literary narrative. The disquieting imageries are also extended to reflect teething challenges faced by Africa’s post-colonies in general. The novel’s portrayal of segregated bodies is entwined with spatial dimensions of power that influence characters’ sense of exclusion and fragility. This study explores and illustrates the various ways in which spatial landscapes are mapped to function as Foucault’s heterotopias – sites of both control and agency. Together, the allegories of pandemics and the frail body in The Wanderers create a striking portrayal of societal dis-ease – underlining the excruciating effects of historic and modern-day malaises and injustices. Lastly, this study contends that Ntabeni’s novel does not only analyse historical and existing power structures, but it also envisions alternative ways of promoting mutual well-being and recovery from past wounds in the current era.Contribution: Mphuthumi Ntabeni’s novel, The Wanderers is yet to receive ample scholarly attention, and this study intends to stimulate such interest in the context of both post-apartheid literature and transnational African literature. Bringing together Foucault and Massey’s theorisation of space and power in reading race, gender and politics of difference, it is intended to offer a refreshing interpretation concerning the human condition as portrayed in the text.