bluuebunny/crossref_metadata_2025 huggingface dataset:
Mit Inklusion gegen den Fachkräftemangel »Förderbezogene Diagnostik in der inklusiven Bildung« und das MInkBi. Einblick
Authors: Katzenbach Stefan
Published: August 2024

Einer der »10 guten Gründe für Inklusion«, die die Aktion Mensch in ihrem Praxishandbuch Inklusion versammelt, ist die Verringerung des Fachkräftemangels. Damit gewinnt das Thema Inklusion nicht nur in der Schule, sondern auch in der Erwachsenenbildung immer mehr an Bedeutung aufgrund des Fachkräftemangels.
Fundstück. Salesman 2.0 ... & Call for Papers
Authors: Rohwerder Jan
Published: August 2024

Salesman 2.0: Am 8. Februar 1949 wurde Arthur Millers Drama »Tod eines Handlungsreisenden« am Broadway uraufgeführt. - Ein solch tragisches Ende des Helden würden die hiesigen heutigen Möglichkeiten der Weiterbildung bestimmt zu verhindern wissen! Ein neuzeitliches und alternatives Happy End - mit kleiner Hilfe von ChatGPT. Themenschwerpunkte für folgende Hefte: Ausgabe 2 - 2024: Weiterbildungsrepublik? Ausgabe 3 - 2024: Bilden für die Demokratie
СУТНІСТЬ ВНУТРІШНЬОГО КОНТРОЛЮ ТА ПИТАННЯ ЙОГО ОРГАНІЗАЦІЇ НА ПІДПРИЄМСТВАХ З ПРОКАТУ МАЙНА
Authors: Воронко Роман , Марценюк Роман
Published: August 2024

Розкрито змістовну сутність внутрішнього контролю, визначено його характерні особливості і призначення в системі управління підприємствами, які здійснюють діяльність у сфері прокату майна. Розглянуто теоретичні аспекти трактування внутрішнього контролю різними науковцями і дано власне визначення цієї категорії. Акцентовано увагу на відсутності єдиного, законодавчо врегульованого порядку створення, функціонування та побудови системи внутрішнього контролю на підприємствах сфери послуг. Досліджено практичні аспекти організації і особливості функціонування системи внутрішнього контролю на підприємствах з прокату майна. Розглянуто зовнішні та внутрішні чинники, які впливають на формування системи внутрішнього контролю. Визначено завдання внутрішнього контролю підприємств з прокату майна щодо забезпечення функцій управлінського впливу та вимоги, які б гарантували її ефективне функціонування. Внутрішній аудит охарактеризовано як складову системи внутрішнього контролю та інструмент зниження різних ризиків в межах визначених системою управління параметрів. Розкрито можливість використання підприємствами з прокату майна аутсорсингу як одного з варіантів організації внутрішнього контролю. Розглянуто концептуальні засади організації системи внутрішнього контролю на підприємствах з прокату майна з визначенням взаємопов’язаних його структурних елементів: мети і завдань; принципів; суб’єктів і об’єктів; контрольних дій; методів функціонування та оцінювання; користувачів контрольної інформації. Встановлено об’єкти внутрішнього контролю (елементи контрольованої підсистеми) діяльності підприємств з прокату майна. Акцентовано на необхідності своєчасного документального оформлення операцій із надходження, видання, ремонту, зносу, вибуття предметів прокату, організації їхнього аналітичного обліку, як інформаційної бази для здійснення внутрішнього контролю. З метою раціональної організації та здійснення внутрішнього контролю на підприємствах з прокату майна запропоновано послідовні стадії його реалізації – початкову, дослідну і завершальну.
DEVELOPING ALGORITHMIC TRADING STRATEGIES USING GENETIC ALGORITHMS
Authors:   Simon Kuznets Kharkiv National University of Economics, Kanyhin Serhii
Published: August 2024

The article presents a methodology for developing trading strategies based on genetic algorithms that use riskoriented metrics for optimization. Data from the Binance cryptocurrency exchange for 2021–2022 was used for development, and similar data for 2022–2024 was used for validation. The methodology was aimed to create the most effective combinations of two input and two output technical indicators. Based on the set of common indicators, all possible input and output signal combinations were generated, ensuring complete coverage of potential options. The total signal for each combination was calculated by summing the signals of individual indicators, which allowed determining the action (buy, hold, sell) at each moment based on the identified indicators. Several ratios (Sharpe, Sortino, Omega, maximum drawdown, and Calmar) assessed the effectiveness of each combination. These metrics allowed for a comprehensive analysis of profitability and risk for each trading strategy. Cases of extreme values were processed using quantiles. All coefficients were normalized using a min-max approach, which brought the data attributes to a standard scale. A genetic algorithm was used to identify the most effective combinations based on the generated evaluation function to optimize the weights. The population size of 8 provided sufficient genetic diversity, allowing the algorithm to explore and exploit the solution space efficiently. Crossover and mutation were used to explore new areas of the solution space, ensuring genetic diversity and preservation of successful traits. The results showed that the best 15 combinations of technical indicators showed an average profit of more than 50% on the validation sample. This indicates the effectiveness of the weights selected by the genetic algorithm when choosing combinations. The best combinations had the same output signals (TEMA+BB), which means their reliability, while the input signals were less stable but had leaders such as ICH and DC. The economic feasibility of the developed methodology is confirmed by high profitability, which is verified by historical data. The proposed approach can be effectively applied to create optimal trading strategies, ensuring high profitability and risk management.
CONSTITUIR-SE HUMANO POR MEIO DAS EXPERIÊNCIAS
Authors: Dahlke Marsoé Cristina , Dumke Jordana Perkoski , Cossetin Vânia Lisa Fischer
Published: August 2024

Este artigo aborda, por meio de pesquisa bibliográfica e análise qualitativa, orientadas pela abordagem crítico-hermenêutica, a formação do ser humano com base em suas experiências. O foco é direcionado para a significativa relevância da linguagem na própria condição humana, evidenciando seu papel crucial na construção do mundo simbólico, na comunicação intersubjetiva e na construção do conhecimento. A partir dessa premissa, procura-se destacar a importância do diálogo na configuração das relações humanas, especialmente enfatizando o reconhecimento dos horizontes interpretativos como elementos fundamentais nesse processo. 
Palavras-chave: Educação. Condição Humana. Hermenêutica. Intersubjetividade
At Childhood’s End: Trauma, Survivance, and the Healing Fantastic in Abhishek Majumdar’s The Djinns of Eidgah
Authors: Chakravorty Mayurika
Published: August 2024

This essay explores how Abhishek Majumdar’s play The Djinns of Eidgah embraces the non-mimetic mode to capture the dyscatastrophe (Tolkien) in the valley – the loss of childhood, radicalization of youth, and the inconceivable brutality and violence. It will analyze how the play casts the radicalized youth as djinns, fantastical beings made of ‘fire, dust, and smoke’, who are caught in the liminal space between life and death, between captivity and freedom, much as the valley is. As the Djinns warn ‘not to expect reason from a world gone wrong’, the play too effectively uses the fantastic to depict the chaos and madness so unrealistic that it challenges the boundaries of the realistic parameters. The paper also examines the use of Dastaan tradition -- legends and stories to add a mythopoeic dimension to the narrative which signals the loss of innocence and a contrapuntal imagining of the past against the trauma of fractured and dislocated present while also presenting a trope for healing, resistance, and survivance.
“Something Miraculous about Them”: ‘Indian Doctors’ and quacks in White Australia, 1880-1930
Authors: Sarwal Amit
Published: August 2024

Delving into the historical narrative of medicine in colonial India and Australia, this article sheds light on a neglected aspect: the role of ‘Indian doctors,’ encompassing oculists and hakims, practitioners of indigenous Indian medicine, within the Australian landscape. Often marginalized in discussions of migration patterns and colonial medical history, these ‘Indian doctors’ possess a rich history intricately interwoven with the complex networks of the British Empire. Drawing upon the insights of scholars who have highlighted the mobility of ‘Indian doctors’ in Britain and Australia, this article underscores their significant presence and impact during the period spanning from 1880 to 1930. Through an analysis of contemporary Australian newspaper reports, the article unveils the popular representations of these practitioners and explores their influence across both regional outposts and urban centres within the confines of White Australia. By bringing the stories of these oft-forgotten healers to the forefront, this article aims to enrich our understanding of colonial medical dynamics and transnational networks.
UPAYA MENINGKATKAN HASIL BELAJAR MELALUI PEMBELAJARAN TEMATIK MENGGUNAKAN MODEL PROBLEM BASED LEARNING (PBL) PADA SISWA KELAS V SD NEGERI WAIMAN
Authors: Haimia Dewi , Somadayo Samsu , Ahsan Sukria
Published: August 2024

Tujuan penelitian ini (1) Untuk mengetahui proses penggunaan model problem based learning pada pembelajaran tematik di kelas V SDN Waiman. (2) Untuk mengetahui peningkatan hasil belajar siswa setelah diberikan pembelajaran tematik menggunakan model Problem Based Learning  di kelas V SDN Waiman. Jenis penelitian yang digunakan adalah penelitian tindakan kelas (PTK) dengan pendekatan kualitatif.Penelitian ini dimulai pada tanggal 9 Agustus sampai 9 September 2023. Subjek penelitian ini adalah siswa kelas V SDN Waiman sebanyak 20 siswa. Instrumen penelitian ini adalah instrument tes berupa 10 soal  pilihan ganda dan lembar observasi aktivitas guru dan siswa.Hasil penelitian menunjukan bahwa,  model pembelajaran Problem Based Learning dapat meningkatkan hasil belajar siswa. Hal ini dibuktikan dengan adanya peningkatan aktivitas dan hasil belajar siswa  siklus I dan siklus II. Ketuntasan belajar siswa pada tes akhir terjadi peningkatan, yakni siklus I diperoleh persentase 40% dan  90% pada siklus II. Aktivitas belajar siswa terjadi peningkatan, yakni 58,9% pada siklus I dan 91,1% pada siklus II. Kata Kunci: Problem Based Learning, Hasil Belajar
PENERAPAN MODEL PEMBELAJARAN PROBLEM POSING SEBAGAI UPAYA MENINGKATKAN HASIL BELAJAR IPA BIOLOGI PADA SISWA KELAS V SDN 4 TIDORE KEPULAUAN
Authors: Panu Rasmi Hi , Purnomo Eko
Published: August 2024

Guru memiliki kesulitan dalam menerapkan konsep IPA Biologi, model pembelajaran problem possing diharapkan menjadi solusi untuk membangun pengetahuan siswa dari pertanyaan yang disusun dengan isu sederhana yang disampaikan guru sehingga rasa ingin tahu dan hasil belajar siswa menjadi meningkat. Penelitian ini bertujuan untuk menerapkan model pembelajaran problem possing sebagai upaya meningkatkan kualitas proses dan hasil belajar biologi pada siswa kelas V SDN 4  Tidore Kepulauan. Hasil penelitian menunjukkan Hasil penelitian ini adalah terdapat peningkatan haasil belajar antara siklus I dengan siklus II. Berdasarkan analisis ketuntasan klasikal hasil belajar siswa yang diperoleh pada siklus I adalah 61,1% atau 11 siswa yang tuntas dan 7 siswa yang tidak tuntas dengan presentasi 38,9%. Sedangkan, pada siklus II terdapat peningkatan yaitu siswa yang tuntas 94,4 % atau 17 siswa dan 1 siswa yang tidak tuntas dengan presentasi 5,6 %. Hal ini disebabkan pada siklus I siswa masih kaku dengan model pembelajaran Problem Possing yang merupakan cara belajar baru bagi mereka sedangkan pada siklus II siswa sudah menguasai alur model pembelajaran Problem Possing ini sehingga mereka lebih aktif dan dapat dengan mudah menerima arahan dan petunjuk dari guru. Kata Kunci : Model Pembelajaran, Problem Possing, Hasil Belajar
Optimizing Glioblastoma, IDH-wildtype Treatment Outcomes : A Radiomics and Support Vector Machine-Based Approach to Overall Survival Estimation
Authors: Chong Jiunn-Kai , Jain Priyanka , Prasad Shivani , Dubey Navneet Kumar , Saxena Sanjay , Lo Wen-Cheng
Published: August 2024

Objective : Glioblastoma multiforme (GBM), particularly the isocitrate dehydrogenase (IDH)-wildtype type, represents a significant clinical challenge due to its aggressive nature and poor prognosis. Despite advancements in medical imaging and its modalities, survival rates have not improved significantly, demanding innovative treatment planning and outcome prediction approaches.Methods : This study utilizes a support vector machine (SVM) classifier using radiomics features to predict the overall survival (OS) of GBM, IDH-wildtype patients to short (<12 months) and long (≥12 months) survivors. A dataset comprising multi-parametric magnetic resonance imaging scans from 574 patients was analyzed. Radiomic features were extracted from T1, T2, fluid-attenuated inversion recovery, and T1 with gadolinium (T1GD) sequences. Low variance features were removed, and recursive feature elimination was used to select the most informative features. The SVM model was trained using a k-fold cross-validation approach. Furthermore, clinical parameters such as age, gender, and MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation status were integrated to enhance prediction accuracy.Results : The model showed reasonable results in terms of cross-validated area under the curve of 0.84 (95% confidence interval, 0.80–0.90) with (p<0.001) effectively categorizing patients into short and long survivors. Log-rank test (chi-square statistics) analysis for the developed model was 0.00029 along with the 1.20 Cohen’s d effect size. Most importantly, clinical data integration further refined the survival estimates, providing a more fitted prediction that considers individual patient characteristics by Kaplan-Meier curve with p-value <0.0001.Conclusion : The proposed method significantly enhances the predictive accuracy of OS outcomes in GBM, IDH-wildtype patients. By integrating detailed imaging features with key clinical indicators, this model offers a robust tool for personalized treatment planning, potentially improving OS.
IMPLEMENTASI TEKNIK SMOTE UNTUK MENGATASI IMBALANCE CLASS DALAM KLASIFIKASI SENTIMEN MENGENAI CHATGPT
Authors: Indrayuni Elly , Nurhadi Acmad
Published: August 2024

ChatGPT is a chatbot or computer program in the form of a virtual robot that can simulate human-like conversations. ChatGPT is widely used in various fields in academia. The impact of the use of ChatGPT on academia and public perception of this technology is significant. Sentiment analysis can be used to determine the polarity of a text or opinion that is positive or negative. In this research, social media is used as a data source to collect public opinion regarding ChatGPT instantly. The methods used in this reserach are the KNN algorithm and Naive Bayes algorithm. The aim of this research is to find the best algorithm model for sentiment classification in terms of public opinion for ChatGPT which contains English text. Before testing the algorithm model, a text processing stage was carried out which included the processes of case folding, tokenizing, stopword removal, and stemming. Word weighting using TF-IDF was carried out before the data was ready to be processed. Splitting data used in this research includes 80% of the dataset as training data and 20% of the dataset as testing data.  The application of the SMOTE technique to the KNN and Naive Bayes algorithms to overcome the imbalance class of the public opinion dataset regarding ChatGPT. The research results show that combining SMOTE and Naive Bayes algorithm gives the best results with an accuracy value of 85.00%, a precision value of 87.64%, a recall value of 84.78% and an f1-score of 86.18%.
Aktivitas PT. Berkah Naira Lines Palembang Dalam Proses Stuffing Kelapa
Authors: Pamujianto Slamet , Supartini Supartini , Marseleno Eko , Sumardi Sumardi , Tri Prasetiawan Saptana
Published: August 2024

Penelitian ini bertujuan mengetahui aktivitas PT. Berkah Naira Lines Palembang dalam Proses stuffing kelapa Di Pelabuhan Boom Baru Palembang. Dimana kegiatannya lebih berkonsentrasi pada kegiatan stuffing yang dilakukan dengan benar dengan maksud muatan yang dapat di stuffing kedalam container dapat mencapai batas maksimal dan load capacity container sehingga keuntungan yang diperoleh dapat optimal dan kerugian yang akan diderita akan semenimal mungkin serta tidak timbulnya claim/biaya tambahan karena kerusakan container akibat kegiatan stuffing. Metode pada penelitian ini adalah kualitatif, dengan analisis yang digunakan adalah analisis deskriptif kualitatif dengan melakukan wawancara (interview), pengamatan (observasi), dan penelaahan dokumen (dokumenter) untuk menggambarkan kondisi yang diharapkan dengan potensi yang ada dilihat dari aspek sejarah, geografis, ekonomi, fasilitas pelabuhan, fasilitas penunjang, dan komoditas khusus. PT. Berkah Naira Lines Palembang didalam proses ekspor kelapa memulai dengan pemeriksaan container dan stuffing oleh Bea Cukai dan Badan Karantina Pertanian. Dokumen pabean dilengkapi dan Pemberitahuan Ekspor Barang diajukan. Pengapalan dilakukan setelah izin pemuatan diperoleh dan stiker karantina terpasang. Tahap akhir adalah input COO dan Phytosanitary, upload ke INSW, dan penyimpanan dokumen selama 10 tahun untuk pemeriksaan Bea Cukai.
Membangun Altruism Crew Kapal KM Baruna
Authors: Hendrawan Andi , Sucahyowati Hari , Indriyani Indriyani , Kusumastuti Hendrawan Aji , Astriawati Ningrum
Published: August 2024

Crew kapal merupakan organisasi yang mapan, yang harus kompak dan serius dalam setiap pekerjaannya karena pekerjaan yang kaku dan semua aturan harus terpenuhi. Oleh karena itu, diperlukan kekompakan dan kohesivitas tim. Kohesivitas tim akan tercipta jika setiap anggota tim memahami kepentingan bersama. Menggantikan rekan kerja yang berhalangan dengan sukarela merupakan salah satu sifat altruism. Penelitian ini bertujuan untuk menunjukkan bagaimana sifat altruism dapat meningkatkan kinerja dan hubungan antar anggota crew, serta bagaimana hal tersebut dapat memperpanjang umur organisasi dan meningkatkan keberhasilan perusahaan. Penelitian ini adalah penelitian kuantitatif dengan mengambil populasi dan sampel semua crew kapal KM Baruna yang berjumlah 30 orang. Penelitian dimulai dengan membuat kuesioner altruism yang kemudian divalidasi. Setelah itu, kuesioner disebarkan kepada semua crew kapal. Data yang diperoleh kemudian diolah dan dianalisis secara deskriptif. Semua indikator Altruism menunjukkan hasil yang sangat baik. Hal ini menunjukkan bahwa Altruism pada crew anak buah kapal KM Baruna sangat baik. Dampak dari altruism yang baik akan meningkatkan kinerja dan hubungan pertemanan antar anggota crew. Pada akhirnya, altruism yang baik akan meningkatkan ketahanan organisasi sehingga umur organisasi menjadi lebih lama dan perusahaan menjadi lebih berjaya.
Optimalisasi Prosedur Pelayanan Perusahaan Pelayaran Sebagai Agen Bunker Dalam Pemuatan Oil product
Authors: Iswanto Iswanto , Pamujianto Slamet , Fahrurozi Ali , Sumardi Sumardi , Fatrodin Fatrodin
Published: August 2024

Penelitian ini bertujuan mengetahui kegiatan pelayanan PT. Arghaniaga Pancatunggal (APT) merupakan perusahaan pelayaran dan agen bunker resmi Pertamina dalam melayani pengisian bahan bakar kapal (supply bunker) untuk memuat (loading) bahan bakar dari Terminal Bahan Bakar Minyak milik Pertamina yang berada di Dermaga Pelabuhan Tanjung Intan Cilacap ke kapal MT. Anugerah Dewi 2. Metode pada penelitian ini adalah kualitatif, dengan analisis yang digunakan adalah analisis deskriptif kualitatif dengan melakukan wawancara (interview), pengamatan (observasi), dan penelaahan dokumen (dokumenter) untuk menggambarkan kondisi yang diharapkan dari proses kegiatan pelayanan dan kesiapan dokumen yang harus dipenuhi untuk kegiatan pemuatan oil product berupa MFO dan B35 sebanyak 650 KL di dermaga Multipurpose Pelabuhan Tanjung Intan ke MT. Anugerah Dewi 2 untuk didistribusikan guna pemenuhan kebutuhan BBM kapal (supply bunker). Dengan tahapan yang perlu dilalui yaitu mulai dari pengurusan izin bongkar muat barang berbahaya ke otoritas pelabuhan, sandar kapal, pemasangan selang atau pipa ke manifold, pengecekan kesiapan dan keselamatan pra loading, memastikan start line up mulai ada aliran. Kemudian tahap selanjutnya adalah monitoring, pengecekan dan komunikasi aktif untuk memastikan aliran lancar dan terukur (steady rate), dan tahap terakhir adalah topping off.
Analisis Proses Replacement Crew Kapal Dan Ketidaksesuaian Jadwal Keberangkatan Pengiriman Crew Sign On
Authors: Hanik Kumila , Papuantya Sindya , Maharani Atria
Published: August 2024

Replacement crew kapal dapat diartikan sebuah kegiatan yang berpengaruh bagi kelancaran crewing management, sehingga adanya jadwal yang memadai dan ketersediaan jumlah crew menjadi faktor dalam kelancaran keberangkatan kapal di PT Horison Maritime Indonesia. Penelitian ini bertujuan untuk mengetahui proses replacement crew kapal di PT Horison Maritime Indonesia, faktor penyebab terjadinya keterlambatan pengiriman crew dan tindakan yang dilakukan oleh PT Horison Maritime Indonesia terhadap ketidaksesuaian jadwal keberangkatan pengiriman crew sign on. Penelitian ini menggunakan mixed methods yang menggabungkan beberapa metode yaitu: metode kuantitatif atau pengukuran, metode kualitatif atau pengamatan secara langsung dan keseluruhan, dan analisis SWOT yakni metode yang didasarkan pada kekuatan dan peluang, kelemahan dan ancaman. Hasil penelitian ini menunjukkan proses replacement crew kapal dari permintaan crew kapal untuk sign off sehingga perusahaan harus mempersiapkan crew pengganti yang sesuai dengan kriteria dari permintaan kapten kapal, faktor control waiting list dan faktor kurangnya minat warga Indonesia untuk bergabung dalam Perusahaan menjadi hambatan dalam pengiriman crew kapal di PT Horison Maritime Indonesia, dalam hal ini perusahaan melakukan Tindakan berupa memperbarui waiting list setelah adanya crew kapal yang sign off, pengarsipan dokumen, melakukan medical check up secara terjadwal dan meyakinkan warga Indonesia unutk bergabung dalam perusahaan.
Výberová publikačná činnosť prof. PhDr. Ferdinanda Uličného, DrSc. do roku 2023
Authors:   University of Prešov, Domenová Marcela
Published: August 2024

Selected Publications of Prof. PhDr. Ferdinand Uličný, DrSc. Until 2023 This inventory has been compiled not as a comprehensive bibliography. However, it is based on previously published personal bibliography of the jubilee (2004), supplemented by another selected bibliography (2011), and other documents from the private archive of Ferdinand Uličný, as well as searches of individual databases of Slovak libraries. The inventory includes only a selected portion (the highest-rated categories) of the jubilee‘s publications and editorial outputs.
Katedra histórie FF UPJŠ v Košiciach: staré tradície – nové začiatky
Authors:   Pavol Jozef Šafárik University in Košice, Šutaj Štefan
Published: August 2024

Department of History FF UPJŠ in Košice: Old Traditions – New Beginnings The article is devoted to the establishment of the Department of History at the Faculty of Arts of Pavol Jozef Šafárik University in Košice in 2008. It summarizes the prerequisites for the successful activity of the Department, in terms of historical, personal, and institutional aspects. Based on analyzed documents and personal experience, it creates a picture of the events that led to the establishment of the Department and analyzes the problems that had to be solved for its successful integretion into the structures of UPJŠ. Special attention is paid to the role of Ferdinand Uličný and Ladislav Tajták in the accreditation process and the formation of the department in its first years of existence.
Analysis of Learners' Errors in Working on Formative Tests on the Topic of Quadratic Equations and Functions
Authors: Zunianto Rizki , Gusmarini
Published: August 2024

The purpose of this study was to determine and analyze the errors of students in working on formative tests on the topic of Equations and Quadratic Functions by completing the perfect square root method and the ABC formula. This type of research is descriptive research with a qualitative approach. In this study, the subjects were taken from 12 students of class XI IT SMKS Dar El Hikmah Pekanbaru, each of which consisted of 2 students from the upper, middle, and lower groups. In this study, data collection techniques based on observation, written formative test questions, and interviews were used to determine students' errors in solving the topic of Quadratic Equations and Functions. In this study, it can be concluded that students' errors in solving the topic of Quadratic Equations and Functions with the method of completing the perfect square root and the ABC formula are the lack of understanding of the concept of the method, the lack of assignment of the topic, and the lack of students' mathematics learning so that students make many mistakes in solving problems.
Development of Realistic Mathematics Education-Based Learner Worksheets (LKPD) to Enhance Higher-Order Thinking Skills in Grade IV Students of SD/MI
Authors: Febriyani Annisa , Habudin  , Rachmiati Wida
Published: August 2024

This study aims to determine the development procedures, feasibility, and effectiveness of mathematical worksheets based on realistic mathematics education to develop high-order thinking skills of fourth-grade students in SD/MI. This research is a research and development (R&D) research using a 4D research model consisting of 4 stages, namely the Define, Design, Development, and Disseminate. The data instruments used in this study were interview observations. The subjects of this study were the fourth-grade students of SDN Sukatani VI, totaling 35 students. The data analysis was qualitative and quantitative. Qualitative data analysis was obtained from observations and interviews, while quantitative data analysis was obtained from expert validation, teacher response questionnaires, and student response questionnaires. The validation results of mathematic education experts, with a percentage of 83%, were categorized as "Good/Valid". Based on the teacher's response, the research results obtained 96% categorized as "Very Good/Decent," and student responses obtained by the assessment results with a percentage of 90.28% categorized as "Very Good" to use. From the results of development trials to assess effectiveness with pretest and posttest get a score of 88.5 above the KKM or a percentage of 82.8% can be categorized as "Very Effective" to use, as well as the recapitulation of pretest and posttest results using the N-Gain test got a score of 0.82 students experienced the development and improvement of learning outcomes.
Prevention of Dental Fear and Anxiety with Behavior Management Techniques
Authors: Berry Elizabeth
Published: August 2024

Dental fear and anxiety can have a significant effect on an individual, ultimately leading to a poor oral health-related quality of life. Many develop fear and anxiety due to an unfortunate experience at the dentist during their childhood. Dentists, with proper training, can treat children and provide behavior management techniques to complete treatment in a positive manner. These behavior management techniques focus on decreasing the fear and anxiety toward a dental procedure and assisting the child to develop the proper skills needed to cope with such procedures in the future.
Agroecological substantiation of meliorative factors for restoration of soils disturbed by military actions
Authors: Korsun S. , Bolokhovska V. , Bolokhovskyi V. , Khomenk T. , Borko Yu. , Demyanyuk O. , Kostyna T.
Published: August 2024

Тhe armed aggression of the Russian Federation has led to the disruption of balance in agroecosystems in Ukraine. The purpose of this study was to investigate the agroecological consequences of soil disturbance in agrocenosis due to explosive ordnance and to justify the use of ameliorative factors for soil fertility restoration. Vegetation studies were conducted at the «Institute of Applied Biotechnology». Soil samples for the experiment were collected from the liberated territories of Kharkiv region affected by military actions. Soil expertise, disrupted by explosive ordnance, revealed changes in agrochemical, biological, and toxicological indicators compared to the control plot of the agrocenosis. The humus content decreased by 39–46%, hydrolyzable nitrogen by 30–38%, mineral nitrogen by 36–48%, while the availability of mobile potassium increased by 115–139%. Significant excess of heavy metals content in the soil was detected: copper content increased by 3 times, lead — by 1.5 times, nickel — by 2.7 times, and cadmium — by 2.5 times. Microbiological processes were characterized by an increase in mineralization-immobilization coefficients, oligotrophy, pedotrophy, and a decrease in organic matter transformation indicator. Based on the observed changes, ameliorative factors were proposed aimed at soil fertility restoration. The application of nitrogen-phosphorus mineral fertilizer, winter wheat straw as organic fertilizer, and the biological preparation EcoStern Detox contributed to the improvement of soil agrochemical properties and optimized the direction of microbiological processes, but had no systemic impact on the change in the quantity of mobile forms of heavy metals. The positive impact of amelioration on the soil environment was confirmed by bioassay. Combining the studied ameliorative factors resulted in a 14.3–18.1% increase in maize plant height at the BBCH 14 stage, an increase in aboveground biomass by 24–46.2%, and root mass by 13.3–14.3% compared to the control. The highest growth in the development of the photosynthetic apparatus and root system was observed with the application of the entire complex of ameliorants. The obtained results are consistent with the soil analysis, as the simultaneous application of the EcoStern Detox biopreparation, mineral fertilizers, and straw led to a significant improvement in both agrochemical and biological soil indicators compared to the control and other research variants.
Promising non-model microbial cell factories obtained by genome reduction
Authors: Ravagnan Giulia , Schmid Jochen
Published: August 2024

The development of sustainable processes is the most important basis to realize the shift from the fossil-fuel based industry to bio-based production. Non-model microbes represent a great resource due to their advantageous traits and unique repertoire of bioproducts. However, most of these microbes require modifications to improve their growth and production capacities as well as robustness in terms of genetic stability. For this, genome reduction is a valuable and powerful approach to meet industry requirements and to design highly efficient production strains. Here, we provide an overview of various genome reduction approaches in prokaryotic microorganisms, with a focus on non-model organisms, and highlight the example of a successful genome-reduced model organism chassis. Furthermore, we discuss the advances and challenges of promising non-model microbial chassis.
Antibacterial and antioxidant phlorizin-loaded nanofiber film effectively promotes the healing of burn wounds
Authors: Yang Ying , Ma Shuang , Li Anning , Xia Guofeng , Li Min , Ding Chuanbo , Sun Xiaofei , Yan Li , Yang Min , Zhao Ting
Published: August 2024

Burns usually result in damage and loss of skin forming irregular wound wounds. The lack of skin tissue protection makes the wound site highly vulnerable to bacterial infections, hindering the healing process. However, commonly used wound dressings do not readily provide complete coverage of irregular wounds compared to regular wounds. Therefore, there is an urgent need to prepare a wound dressing with high antimicrobial efficacy for the administration of drugs to irregular wounds. In this study, a chitosan (CS)/polyvinylpyrrolidone (PVP) composite nanofiber membrane (CS/PVP/Phlorizin) loaded with root bark glycosides (Phlorizin) was developed using an electrostatic spinning technique. The incorporation of phlorizin, a natural antioxidant, into the fiber membranes notably boosted their antimicrobial and antioxidant capabilities, along with demonstrating excellent hydrophilic characteristics. In vitro cellular experiments showed that CS/PVP/Phlorizin increased Hacat cell viability with the presence of better cytocompatibility. In scald wound healing experiments, Phlorizin-loaded nanofibrous membranes significantly promoted re-epithelialization and angiogenesis at the wound site, and reduced the inflammatory response at the wound site. Therefore, the above results indicate that this nanofiber membrane is expected to be an ideal dressing for burn wounds.
The essential roles of lncRNAs/PI3K/AKT axis in gastrointestinal tumors
Authors: Li Penghui , Ma Xiao , Gu Xinyu
Published: August 2024

The role of long noncoding RNA (lncRNA) in tumors, particularly in gastrointestinal tumors, has gained significant attention. Accumulating evidence underscores the interaction between various lncRNAs and diverse molecular pathways involved in cancer progression. One such pivotal pathway is the PI3K/AKT pathway, which serves as a crucial intracellular mechanism maintaining the balance among various cellular physiological processes for normal cell growth and survival. Frequent dysregulation of the PI3K/AKT pathway in cancer, along with aberrant activation, plays a critical role in driving tumorigenesis. LncRNAs modulate the PI3K/AKT signaling pathway through diverse mechanisms, primarily by acting as competing endogenous RNA to regulate miRNA expression and associated genes. This interaction significantly influences fundamental biological behaviors such as cell proliferation, metastasis, and drug resistance. Abnormal expression of numerous lncRNAs in gastrointestinal tumors often correlates with clinical outcomes and pathological features in patients with cancer. Additionally, these lncRNAs influence the sensitivity of tumor cells to chemotherapy in multiple types of gastrointestinal tumors through the abnormal activation of the PI3K/AKT pathway. These findings provide valuable insights into the mechanisms underlying gastrointestinal tumors and potential therapeutic targets. However, gastrointestinal tumors remain a significant global health concern, with increasing incidence and mortality rates of gastrointestinal tumors over recent decades. This review provides a comprehensive summary of the latest research on the interactions of lncRNA and the PI3K/AKT pathway in gastrointestinal tumor development. Additionally, it focuses on the functions of lncRNAs and the PI3K/AKT pathway in carcinogenesis, exploring expression profiles, clinicopathological characteristics, interaction mechanisms with the PI3K/AKT pathway, and potential clinical applications.
The muon beam monitor for the FAMU experiment: design, simulation, test, and operation
Authors: Rossini R. , Baldazzi G. , Banfi S. , Baruzzo M. , Benocci R. , Bertoni R. , Bonesini M. , Carsi S. , Cirrincione D. , Clemenza M. , Colace L. , De Bari A. , De Vecchi C. , Fasci E. , Gaigher R. , Gianfrani L. , Hillier A. D. , Ishida K. , King P. J. C. , Lord J. S. , Mazza R. , Menegolli A. , Mocchiutti E. , Monzani S. , Moretti L. , Petroselli C. , Pizzolotto C. , Prata M. C. , Pullia M. , Quintieri L. , Ramponi R. , Rossella M. , Sbrizzi A. , Toci G. , Tortora L. , Vallazza E. S. , Yokoyama K. , Vacchi A.
Published: August 2024

FAMU is an INFN-led muonic atom physics experiment based at the RIKEN-RAL muon facility at the ISIS Neutron and Muon Source (United Kingdom). The aim of FAMU is to measure the hyperfine splitting in muonic hydrogen to determine the value of the proton Zemach radius with an accuracy better than 1%. The experiment has a scintillating-fibre hodoscope for beam monitoring and data normalisation. In order to carry out muon flux estimation, low-rate measurements were performed to extract the single-muon average deposited charge. Then, detector simulation in Geant4 and FLUKA allowed a thorough understanding of the single-muon response function, which is crucial for determining the muon flux. This work presents the design features of the FAMU beam monitor, along with the simulation and absolute calibration measurements in order to enable flux determination and enable data normalisation.
Monitoring and disaster prevention of high and steep sandstone slopes along highways under construction
Authors: Liu Xianlin , Lü Xilin , Shao Yu , Chen Chuan , Liu Guangbin , Li Yishan , Li Mingzhi , Wu Xinyu , Chen Youdong
Published: August 2024

High and steep sandstone slopes along highway line are at high risk of disasters such as landslides, cracking of support structures, and so on. The monitoring, early warning, and emergency response of such slope disaster face enormous challenges, especially during the rainy season. In this paper, intelligent monitoring, early warning and forecasting system were carried out for the high steep sandstone slope with a transmission line tower at the slope crest along the highway under construction in Guangxi, China. The automatic monitoring data, emergency rescue program and rescue effect were analyzed, and emergency rescue measures for high steep slope protection were taken. The research results show that timely access to disaster warning information can effectively support the analysis of disaster causes and the evaluation of disposal programs. Deep-hole monitoring of deformation characteristics can determine the stable state of slopes, and the tangent angle warning criterion can be used for early warning and prediction of high steep slope landslides. By analyzing the location of the sliding surface and taking timely emergency disposal measures such as layered counterpressure method and micropipes, the landslide activities can be effectively controlled to prevent further acceleration of slope collapse. This study can provide an important reference for the monitoring, early warning, forecasting and emergency rescue of sandstone slopes along highways under construction.
Time series monitoring and analysis of Pakistan’s mangrove using Sentinel-2 data
Authors: Raza Syed Ahmed , Zhang Li , Zuo Jian , Chen Bowei
Published: August 2024

Sustainable Development Goal-14 (SDG-14) directly demands the protection, conservation, restoration, and sustainable management of the global mangrove ecosystem. Assessment of the development Pakistan has made toward the sustainable management of mangrove ecosystems necessitates the remote sensing-based evaluation of national-level mangrove cover. Using Google Earth Engine (GEE) for geoprocessing 12,000+ 10-m high-spatial resolution Sentinel-2 time-series images (2016–23) and applying random forest (RF) classifier, the current research provides the latest spatial distribution of mangroves along Pakistan’s coastline and changes observed for a duration of 8 years. Additionally, this research provides the first spatiotemporal health assessment of Pakistan’s national mangrove cover as well. Rational analysis of the results indicated splitting the entire timeline based on two seasons (Jan–Jun and Jul–Dec). Results revealed an overall increase of 1,210 km2 (2023) in the mangrove cover on the national-level; a 3.42 km2 average annual increase from 2016 (1,186 km2). Mangrove gain/loss assessment based on the land use land cover (LULC) transition matrix illustrated 223 km2 gain and 199 km2 loss; a 24 km2 net gain. Declines of 20.28% and 7.91% were found in maximum- and mean-NDVI (2016-23), depicting the deteriorating mangrove health conditions. Likewise, significant Sen’s slope analysis (p < 0.05) indicated that 88.8% of all the mangrove-NDVI pixels exhibited an overall decrease, whereas 11.2% pixels showed an overall increase (2016-23). It was concluded that despite showing a growth in the extent, mangrove cover in Pakistan has shown a decline in health, primarily due to deforestation for urban operations and sea-level rise, still making them vulnerable and potentially leading to a disrupted ecosystem, including carbon release in the atmosphere. This study will assist in the formulation of mangrove conservation and management strategies, whereas future research can explore the potentials of land surface temperature (LST) and evapotranspiration in combination to the NDVI for an in-depth analysis of the health status of mangroves.
Advances and challenges in anti-cancer vaccines for multiple myeloma
Authors: Abdollahi Pegah , Norseth Hanne Marie , Schjesvold Fredrik
Published: August 2024

Multiple myeloma (MM) is a hematological cancer marked by plasma cell accumulation in the bone marrow. Despite treatment advancements, MM remains incurable in most patients. MM-associated immune dysregulation fosters disease progression, prompting research into immunotherapy to combat the disease. An area of immunotherapy investigation is the design of myeloma vaccine therapy to reverse tumor-associated immune suppression and elicit tumor-specific immune responses to effectively target MM cells. This article reviews vaccine immunotherapy for MM, categorizing findings by antigen type and delivery method. Antigens include idiotype (Id), tumor-associated (TAA), tumor-specific (TSA), and whole tumor lysate. Myeloma vaccination has so far shown limited clinical efficacy. However, further studies are essential to optimize various aspects, including antigen and patient selection, vaccine timing and sequencing, and rational combinations with emerging MM treatments.
The current status and future of targeted-immune combination for hepatocellular carcinoma
Authors: Hao Liyuan , Li Shenghao , Ye Fanghang , Wang Hengyi , Zhong Yuxin , Zhang Xiaoyi , Hu Xiaoyu , Huang Xiaopeng
Published: August 2024

Hepatocellular carcinoma (HCC) is one of the most common cancers and the third leading cause of death worldwide. surgery, transarterial chemoembolization (TACE), systemic therapy, local ablation therapy, radiotherapy, and targeted drug therapy with agents such as sorafenib. However, the tumor microenvironment of liver cancer has a strong immunosuppressive effect. Therefore, new treatments for liver cancer are still necessary. Immune checkpoint molecules, such as programmed death-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T lymphocyte antigen-4 (CTLA-4), along with high levels of immunosuppressive cytokines, induce T cell inhibition and are key mechanisms of immune escape in HCC. Recently, immunotherapy based on immune checkpoint inhibitors (ICIs) as monotherapy or in combination with tyrosine kinase inhibitors, anti-angiogenesis drugs, chemotherapy agents, and topical therapies has offered great promise in the treatment of liver cancer. In this review, we discuss the latest advances in ICIs combined with targeted drugs (targeted-immune combination) and other targeted-immune combination regimens for the treatment of patients with advanced HCC (aHCC) or unresectable HCC (uHCC), and provide an outlook on future prospects. The literature reviewed spans the last five years and includes studies identified using keywords such as “hepatocellular carcinoma,” “immune checkpoint inhibitors,” “targeted therapy,” “combination therapy,” and “immunotherapy”.
Urinary excretion of gluten immunoreactive peptides as an indicator of gastrointestinal function after fasting and dietary provocation in healthy volunteers
Authors: Rodríguez-Ramírez Raquel , Fernández Peralbo María Auxiliadora , Mendía Irati , Long Joshua C. D. , Sousa Carolina , Cebolla Ángel
Published: August 2024

Introduction

Understanding intestinal permeability is paramount for elucidating gastrointestinal health and pathology. The size and nature of the molecule traversing the intestinal barrier offer crucial insights into various acute and chronic diseases, as well as the evolution of some conditions. This study aims to assess the urinary excretion kinetics of gluten immunogenic peptides (u-GIP), a unique class of dietary peptides detectable in urine, in volunteers under controlled dietary conditions. This evaluation should be compared to established probes like lactulose, a non-digestible disaccharide indicative of paracellular permeability, and mannitol, reflecting transcellular permeability.

Methods

Fifteen participants underwent simultaneous ingestion of standardized doses of gluten (10 g), lactulose (10 g), and mannitol (1 g) under fasting conditions for at least 8 hours pre-ingestion and during 6 hours post-ingestion period. Urine samples were collected over specified time intervals. Excretion patterns were analyzed, and correlations between the lactulose-to-mannitol ratio (LMR) and u-GIP parameters were assessed.

Results

The majority of u-GIP were detected within the first 12 hours post-ingestion. Analysis of the variability in cumulative excretion across two sample collection ranges demonstrated that lactulose and u-GIP exhibited similar onset and excretion dynamics, although GIP reached its maximum peak earlier than either lactulose or mannitol. Additionally, a moderate correlation was observed between the LMR and u-GIP parameters within the longest urine collection interval, indicating potential shared characteristics among permeability pathways. These findings suggest that extending urine collection beyond 6 hours may enhance data reliability.

Discussion

This study sheds light on the temporal dynamics of u-GIP in comparison to lactulose and mannitol, established probes for assessing intestinal permeability. The resemblance between u-GIP and lactulose excretion patterns aligns with the anticipated paracellular permeability pathway. The capacity to detect antigenic food protein fragments in urine opens novel avenues for studying protein metabolism and monitoring pathologies related to the digestive and intestinal systems.
Dendritic cells transfected with DNA constructs encoding CCR9, IL-10, and type II collagen demonstrate induction of immunological tolerance in an arthritis model
Authors: Fisher Marina S. , Kurilin Vasily V. , Bulygin Aleksey S. , Shevchenko Julia A. , Philippova Julia G. , Taranov Oleg S. , Ivleva Elena K. , Maksyutov Amir Z. , Sennikov Sergey V.
Published: August 2024

Introduction

Restoring immune tolerance is a promising area of therapy for autoimmune diseases. One method that helps restore immunological tolerance is the approach using tolerogenic dendritic cells (tolDCs). In our study, we analyzed the effectiveness of using dendritic cells transfected with DNA constructs encoding IL-10, type II collagen, and CCR9 to induce immune tolerance in an experimental model of arthritis.

Methods

Dendritic cell cultures were obtained from bone marrow cells of Balb/c mice. Dendritic cells (DCs) cultures were transfected with pmaxCCR9, pmaxIL-10, and pmaxCollagen type II by electroporation. The phenotype and functions of DCs were studied using enzyme-linked immunosorbent assay (ELISA) and flow cytometry. Migration of electroporated DCs was assessed in vitro. Induction of antigen-collagen induced arthritis (ACIA) was carried out according to the protocol in Balb/c mice. DCs were then administered to ACIA mice. The development of arthritis was monitored by measuring paw swelling with a caliper at different time points. The immunological changes were assessed by analyzing the content of antibodies to type II collagen using enzyme immunoassay. Additionally, a histological examination of the joint tissue was conducted, followed by data analysis.

The results are as follows

DCs were obtained, characterized by reduced expression of CD80, CD86, and H-2Db (MHC class I), increased expression of CCR9, as well as producing IL-10 and having migratory activity to thymus cells. Transfected DCs induced T-regulatory cells (T-reg) and increased the intracellular content of IL-10 and TGF-β in CD4+T cells in their co-culture, and also suppressed their proliferative activity in response to antigen. The administration of tolDCs transfected with DNA constructs encoding type II collagen, IL-10, and CCR9 to mice with ACIA demonstrated a reduction in paw swelling, a reduction in the level of antibodies to type II collagen, and a regression of histological changes.

Conclusion

The study presents an approach by which DCs transfected with DNA constructs encoding epitopes of type II collagen, IL-10 and CCR9 promote the development of antigen-specific tolerance, control inflammation and reduce the severity of experimental arthritis through the studied mechanisms: induction of T-reg, IL-10, TGF-β.