bluuebunny/crossref_metadata_2025 huggingface dataset:
Allergic Diseases and Risk of Malignancy of Gastrointestinal Cancers
Authors: Choi Yoon Jin , Han Kyungdo , Jin Eun Hyo , Lim Joo Hyun , Shin Cheol Min , Lee Dong Ho
Published: June 2023

The aim of this study was to investigate the effect of allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, on the development of gastrointestinal (GI) cancers. We analyzed 9,892,633 Korean adults who underwent a medical check-up in the year 2009, and they were followed up until the year 2017. Allergic diseases and cancers were defined using the International Classification of Disease Codes. A Cox proportional hazards model was adapted to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). During a 7.3-year follow-up period, 48,045 patients were diagnosed with cancer. For all-combined allergic diseases, significant inverse associations were observed for cancers of the esophagus, stomach, colorectum, and liver (adjusted hazard ratios (aHRs [95% confidence interval, CI] 0.86 [0.82–0.91], 0.93 [0.91–0.94], 0.95 [0.93–0.96], and 0.90 [0.88–0.92], respectively). The sex-stratified analysis showed that the preventive effect of allergic diseases was persistent in gastric, colorectal, and liver cancers regardless of sex, while the inverse associations with esophageal and pancreatic cancers were observed only in men (aHR [95% CI] 0.84 [0.80–0.89] and 0.96 [0.93–0.99]). Allergic diseases, particularly allergic rhinitis, in adults were significantly associated with a decreased risk of most GI cancers, except for gallbladder and biliary tract cancers.
Chasing Immune Checkpoint Inhibitors in Ovarian Cancer: Novel Combinations and Biomarker Discovery
Authors: Colombo Ilaria , Karakasis Katherine , Suku Sneha , Oza Amit M.
Published: June 2023

A deep understanding of the tumor microenvironment and the recognition of tumor-infiltrating lymphocytes as a prognostic factor have resulted in major milestones in immunotherapy that have led to therapeutic advances in treating many cancers. Yet, the translation of this knowledge to clinical success for ovarian cancer remains a challenge. The efficacy of immune checkpoint inhibitors as single agents or combined with chemotherapy has been unsatisfactory, leading to the exploration of alternative combination strategies with targeted agents (e.g., poly-ADP-ribose inhibitors (PARP)and angiogenesis inhibitors) and novel immunotherapy approaches. Among the different histological subtypes, clear cell ovarian cancer has shown a higher sensitivity to immunotherapy. A deeper understanding of the mechanism of immune resistance within the context of ovarian cancer and the identification of predictive biomarkers remain central discovery benchmarks to be realized. This will be critical to successfully define the precision use of immune checkpoint inhibitors for the treatment of ovarian cancer.
Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019)
Authors: Tran Ngoc , Fantegrossi William E. , McCain Keith R. , Wang Xinwen , Fujiwara Ryoichi
Published: June 2023

(1-Hexyl-1H-indol-3-yl)-1-naphthalenyl-methanone (JWH-019) is one of the second-generation synthetic cannabinoids which as a group have been associated with severe adverse reactions in humans. Although metabolic activation can be involved in the mechanism of action, the metabolic pathway of JWH-019 has not been fully investigated. In the present study, we aimed to identify the enzymes involved in the metabolism of JWH-019. JWH-019 was incubated with human liver microsomes (HLMs) and recombinant cytochrome P450s (P450s or CYPs). An animal study was also conducted to determine the contribution of the metabolic reaction to the onset of action. Using an ultra-performance liquid chromatography system connected to a single-quadrupole mass detector, we identified 6-OH JWH-019 as the main oxidative metabolite in HLMs supplemented with NADPH. JWH-019 was extensively metabolized to 6-OH JWH-019 in HLMs with the KM and Vmax values of 31.5 µM and 432.0 pmol/min/mg. The relative activity factor method estimated that CYP1A2 is the primary contributor to the metabolic reaction in the human liver. The animal study revealed that JWH-019 had a slower onset of action compared to natural and other synthetic cannabinoids. CYP1A2 mediates the metabolic activation of JWH-019, contributing to the slower onset of its pharmacological action.
Vascular Inflammatory Diseases and Endothelial Phenotypes
Authors: Immanuel Jenita , Yun Sanguk
Published: June 2023

The physiological functions of endothelial cells control vascular tone, permeability, inflammation, and angiogenesis, which significantly help to maintain a healthy vascular system. Several cardiovascular diseases are characterized by endothelial cell activation or dysfunction triggered by external stimuli such as disturbed flow, hypoxia, growth factors, and cytokines in response to high levels of low-density lipoprotein and cholesterol, hypertension, diabetes, aging, drugs, and smoking. Increasing evidence suggests that uncontrolled proinflammatory signaling and further alteration in endothelial cell phenotypes such as barrier disruption, increased permeability, endothelial to mesenchymal transition (EndMT), and metabolic reprogramming further induce vascular diseases, and multiple studies are focusing on finding the pathways and mechanisms involved in it. This review highlights the main proinflammatory stimuli and their effects on endothelial cell function. In order to provide a rational direction for future research, we also compiled the most recent data regarding the impact of endothelial cell dysfunction on vascular diseases and potential targets that impede the pathogenic process.
Hyperglycosylated-hCG: Its Role in Trophoblast Invasion and Intrauterine Growth Restriction
Authors: Herghelegiu Catalin Gabriel , Veduta Alina , Stefan Miruna Florina , Magda Stefania Lucia , Ionascu Iuliana , Radoi Viorica Elena , Oprescu Daniela Nuti , Calin Alina Mihaela
Published: June 2023

Human chorionic gonadotropin (hCG) is produced by the placenta and its roles have been studied for over a century, being the first known pregnancy-related protein. Although its main role is to stimulate the production of progesterone by corpus luteal cells, hCG does not represent just one biologically active molecule, but a group of at least five variants, produced by different cells and each with different functions. The hyperglycosylated variant of hCG (H-hCG) plays a key role in trophoblast invasion, placental development and fetal growth. During trophoblast invasion, H-hCG promotes extravillous cytotrophoblast cells to infiltrate the decidua, and also to colonize and remodel the spiral arteries in to low resistance, larger-diameter vessels. As fetal growth is heavily reliant on nutrient availability, impaired trophoblast invasion and remodeling of the uterine arteries, leads to a defective perfusion of the placenta and fetal growth restriction. Understanding the function of H-hCG in the evolution of the placenta might unveil new ways to manage and treat fetal growth restriction.
Characterization of Two Types of Polylactic Acid Coating Loaded with Gentamicin Sulphate Deposed on AZ31 Alloy
Authors: Voicu Manuela Elena , Ionita Daniela , Buica George-Octavian , Draganescu Doina , Anuta Valentina , Raduly Florentina Monica , Demetrescu Ioana
Published: June 2023

This paper compares two types of polylactic acid (PLA) coating on AZ31 alloy obtained by dip coating and electrospinning. Both types of coating were loaded with gentamicin sulphate (GS) and the drug-loading efficiency and release were assessed. A higher encapsulation and release efficiency of GS was seen for dip coating (73% and 49.53%, respectively) compared to nanofiber coating (65% and 12.37%, respectively). Furthermore, the antibacterial effect of the samples with and without GS was assessed using Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria, showing that the samples with the drug encapsulated are more resistant to bacteria than the other samples. The electrochemical data reveal a higher stability in the SBF of the surface obtained by dipping than that obtained by electrospinning. The PLA coating shows a porosity of 46% for the sample obtained through dip coating and 32% for nanofibers, which is in accordance with the BET analysis results. Moreover, a higher adhesion strength was obtained for AZ31-PLA-dip (4.99 MPa) than for the AZ31-PLA-nanofibers (1.66 MPa). All samples were structurally, morphologically, and topographically characterized.
Theoretical and Experimental Studies of 1-Dodecyl-3-phenylquinoxalin-2(1H)-one as a Sustainable Corrosion Inhibitor for Carbon Steel in Acidic Electrolyte
Authors: Benhiba Fouad , Missioui Mohcine , Lamghafri Selma , Hsissou Rachid , Bellaouchou Abdelkbir , Oudda Hassan , Lamhamdi Abdellatif , Warad Ismail , Ramli Youssef , Zarrouk Abdelkader
Published: June 2023

The anti-corrosion features of 1-dodecyl-3-phenylquinoxalin-2(1H)-one (QO12) for carbon steel CS were evaluated in a 1 M HCl solution using potentiodynamic polarization (PDP), electrochemical impedance (EIS) and UV-visible spectroscopy, and scanning electron microscopy (SEM), as well as quantum-chemical methods. The inhibition performance achieves a maximum of 95.33% at 0.001 M. The PDP study revealed that QO12 acts with the character of a mixed-type inhibitor. The EISs mention that the process of corrosion for CS is essentially predominated by the transfer-of-charge mechanism. Moreover, quinoxalinone adsorption follows the Langmuir adsorption isotherm. SEM snapshots show no deterioration after the contribution of QO12 compared to the reference electrolyte. Theoretical calculations suggest that the envisaged inhibitor presents a perfect arrangement capacity through the structure of quinoxalinone.
Morphological Evolution of La2NiO4 Coatings Synthesized by Reactive Magnetron Sputtering (RMS) at High Pressure as Cathode for Intermediate Temperature Solid Oxide Fuel Cell (IT-SOFC)
Authors: Ye Xiaolei , Luo Huan , Hou Ming , Bertrand Pierre , Billard Alain , Briois Pascal
Published: June 2023

This work focuses on the evolution of the morphology and structure of La2NiO4 (namely, LNO) coatings deposited by reactive magnetron sputtering (RMS) with subsequent annealing processes. The LNO coatings start to crystallize at 600 °C, and the LNO with K2NiF4 structure was formed at 700 °C. A small amount of La3Ni2O7 appeared in the La2NiO4 coatings at 1100 °C. Interestingly, the LNO coatings realize the transformation from dense to different porous morphologies due to the annealing process. The LNO coating with abundant pores was formed after annealing treatment at 1000 °C for 2 h. This porous morphology can be stably maintained after short-term thermal stability experiments at 750 °C for 120 h. The electrochemical impedance spectroscopy (EIS) measurement of the LNO/YSZ/LNO symmetrical half-cells shows that the LNO cathode coating after annealing at 1000 °C for 2 h exhibits lower polarization resistance (Rpol) and activation energy.
TIC Reorientation under Electric and Magnetic Fields in Homeotropic Samples of Cholesteric LC with Negative Dielectric Anisotropy
Authors: Oswald Patrick , Poy Guilhem , Ignés-Mullol Jordi
Published: June 2023

In this paper, we numerically and experimentally show that the director field orientation degeneracy within the Translationally Invariant Configuration (TIC) of a cholesteric liquid crystal under an electric field can be lifted by imposing a magnetic field B→ parallel to the electrodes. The configuration can be either parallel or perpendicular to the magnetic field depending on the values of the sample thickness, pitch, and applied voltage, with two equiprobable orientations in each case. The transition between the parallel and perpendicular orientations has hysteresis, suggesting that it is first order. When B→ is slightly tilted with respect to the electrode plane, the indeterminacy on the TIC orientation is removed when the TIC is directed along B→.
Atomic Arrangement, Hydrogen Bonding and Structural Complexity of Alunogen, Al2(SO4)3·17H2O, from Kamchatka Geothermal Field, Russia
Authors: Zhitova Elena S. , Sheveleva Rezeda M. , Zolotarev Andrey A. , Nuzhdaev Anton A.
Published: June 2023

Alunogen, Al2(SO4)3·17H2O, occurs as an efflorescent in acid mine drainage, low-temperature fumarolic or pseudofumarolic (such as with coal fires) terrestrial environments. It is considered to be one of the main Al-sulphates of Martian soils, demanding comprehensive crystal-chemical data of natural terrestrial samples. Structural studies of natural alunogen were carried out in the 1970s without localization of H atoms and have not been previously performed for samples from geothermal fields, despite the fact that these environments are considered to be proxies of the Martian conditions. The studied alunogen sample comes from Verkhne–Koshelevsky geothermal field (Koshelev volcano, Kamchatka, Russia). Its chemical formula is somewhat dehydrated, Al2(SO4)3·15.8H2O. The crystal structure was solved and refined to R1 = 0.068 based on 5112 unique observed reflections with I > 2σ(I). Alunogen crystalizes in the P-1 space group, a = 7.4194(3), b = 26.9763(9), c = 6.0549(2) Å, α = 90.043(3), β = 97.703(3), γ = 91.673(3) °, V = 1200.41(7) Å3, Z = 2. The crystal structure consists of isolated SO4 tetrahedra, Al(H2O)6 octahedra and H2O molecules connected by hydrogen bonds. The structure refinement includes Al, S and O positions that are similar to previous structure determinations and thirty-four H positions localized for the natural sample first. The study also shows the absence of isomorphic substitutions in the composition of alunogen despite the iron-enriched environment of mineral crystallization. The variability of the alunogen crystal structure is reflected in the number of the “zeolite” H2O molecules and their splitting. The structural complexity of alunogen and its modifications ranges from 333–346 bits/cell for models with non-localized H atoms to 783–828 bits/cell for models with localized H atoms. The higher values correspond to the higher hydration state of alunogen.
Hidden Depths: A Unique Biodiversity Oasis in the Persian Gulf in Need of Further Exploration and Conservation
Authors: Samimi-Namin Kaveh , Hoeksema Bert W.
Published: June 2023

The Persian Gulf, a young and shallow epicontinental sea, is known for its unique geological and oceanographic characteristics that foster its diverse and productive marine ecosystems. A substantial portion of the Gulf’s seafloor consists of unconsolidated soft sediments, making it unsuitable for colonization by many sessile organisms. Consequently, relatively few hard grounds and submerged banks provide suitable habitats for benthic and substrate dwellers. This study documents a unique marine habitat on an offshore submerged bank, likely a raised salt dome, south of Qeshm Island, Iran. This area is home to a high concentration of ahermatypic coral species and remains relatively sheltered from human activities. The bank’s geographic location allows inflow currents from the Strait of Hormuz to transport larvae and nutrients, providing suitable substrates for various sessile invertebrates. Moreover, it causes the formation of Taylor columns, which affect fluid dynamics and circulation patterns, indirectly enhancing biodiversity. Despite facing risks from large-scale regional and localized threats, the bank’s remoteness from the main coast and its depth provide some protection. This study emphasizes the need for continued exploration and the implementation of effective conservation measures in the region, along with additional research to clarify the ecological and physical parameters supporting its diversity. It also presents the first in situ photographic evidence for the occurrence of some octocoral genera in the Gulf. Future research should investigate how the species compositions of hidden banks and shoals contribute to the overall biodiversity of the Persian Gulf.
Macrobenthos of the Tortolì Lagoon: A Peculiar Case of High Benthic Biodiversity among Mediterranean Lagoons
Authors: Giampaoletti Jacopo , Sbrana Alice , Magni Paolo , Gravina Maria Flavia
Published: June 2023

Coastal lagoons and brackish ponds are extremely dynamic and temporary ecosystems that follow natural changes throughout their geological history. The correct management of the lagoons ensures their integrity and proper functioning. For this reason, their ecological status should be surveyed for assessing the most appropriate strategies of use. In the present study, historical datasets collected in 2003–2004 are used to investigate the spatiotemporal variation in the species composition and community structure of the macrobenthos of the Tortolì Lagoon (Sardinia, Italy) and to assess their relationship with key environmental variables. Owing to the presence of a riverine runoff at a site and confined areas at some distance from the sea inlet, we hypothesize the marked spatiotemporal changes of the macrobenthic community consistent with the high environmental variability typical of coastal lagoons. The results show a surprisingly high benthic biodiversity for a medium-sized lagoon (250 ha), with 101 species unevenly distributed across the lagoon. The environmental variables did not explain the zonation of the macrobenthic community as that typically found along a lagoonal gradient, due to a marked marine influence. The sampling sites were in fact discriminated by the species distribution according to their ecological affinity; in particular, the most distinctive characteristics of the Tortolì Lagoon emerged from the strictly marine species that represented the most abundant group, consistently with the high marinization of the lagoon. Our results show that the Tortolì Lagoon constitutes a peculiar ecosystem within Mediterranean lagoons, departing from the classic confinement theory.
A Robust FISH Assay to Detect FGFR2 Translocations in Intrahepatic Cholangiocarcinoma Patients
Authors: Zhang Lei , Zheng Hao , Xu Linyu , You Si , Shen Yuanyuan , Han Yang , Anderson Steve
Published: June 2023

FGFR fusions retaining the FGFR kinase domain are active kinases that are either overexpressed or constitutively activated throughout diverse cancer types. The presence of FGFR translocations enhances tumor cell proliferation and contributes to significant sensitivity to FGFR kinase inhibitors. FGFR2 as an actionable target in intrahepatic cholangiocarcinoma (iCCA) has been tested in many clinical trials. FISH (fluorescence in situ hybridization) and NGS (next-generation sequence) are well-known tools to investigate the translocations of FGFR with multiple or unknown translocation partners. A rapid and robust FISH assay was developed and validated to detect FGFR2 translocations from FFPE specimens in iCCA. The analytical performance of the FISH assay was evaluated for probe localization, probe sensitivity and specificity, and assay precision. Twenty-five archival FFPE specimens from local iCCA patients were tested for FGFR2 translocations. FISH results were correlated with that of NGS on some samples. Biallelic translocations and a novel FGFR2 translocation involving the partner gene, SHROOM3, t(4;10) (q21;q26), were identified in a local iCCA patient.
Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience
Authors: Terzi Silvia , Trentin Federica , Griffoni Cristiana , Carretta Elisa , Bandiera Stefano , Ferrari Cristina , Vita Fabio , Righi Alberto , Maioli Margherita , De Biase Dario , Monetta Annalisa , Barbanti Brodano Giovanni , Evangelisti Gisberto , Girolami Marco , Pipola Valerio , Gambarotti Marco , Gasbarrini Alessandro
Published: June 2023

Lung cancer is the second most frequently diagnosed cancer in the world, and surgery is an integral part of the treatment for spinal metastases. The aims of this retrospective study were to assess the overall survival of surgically treated patients affected by lung cancer spinal metastases and identify any factors related to a better survival rate. We recruited 56 consecutive patients (34 male and 22 female) surgically treated for metastatic lung cancer in the spine from 2009 to 2019. Surgical indications were based on a previously published and validated flow chart following a multidisciplinary evaluation. We assessed the localization of vertebral metastases, the presence of other bone or visceral metastases, neurological status according to the Frankel score, ambulatory autonomy, and general status, measured with the Karnofsky performance scale. The expected prognosis was retrospectively assessed according to the revised Tokuhashi score. The median survival was 8.1 months, with over a third of patients surviving more than 1 year. We observed a global improvement in all clinical parameters after surgical treatment. The Tokuhashi predictive score did not correlate with survival after surgery. The results of this study suggest that the surgical treatment of symptomatic spinal metastases from lung cancer can improve quality of life, even in patients with a shorter life expectancy, by controlling pain and improving autonomy.
Deep Reinforcement Learning-Based Joint Scheduling of 5G and TSN in Industrial Networks
Authors: Zhu Yuan , Sun Lei , Wang Jianquan , Huang Rong , Jia Xueqin
Published: June 2023

5th-Generation (5G) and Time-Sensitive Networking (TSN) are regarded as competitive new technologies for future industrial networks; 5G-TSN collaboration transmission has drawn more attention because it can provide a guarantee of low-latency, ultra-reliable and deterministic transmission for time-critical automation applications. However, the methodologies of resource scheduling mechanisms in 5G and Time-Sensitive Networking (TSN) are quite different, which may lead to an inefficient Quality of Service (QoS) guarantee for deterministic transmission across 5G and TSN. Therefore, an efficient 5G-TSN joint scheduling algorithm based on Deep Deterministic Policy Gradient (DDPG) is proposed and analyzed in this article. The proposed algorithm takes both 5G radio channel information and the Gate Control List (GCL) state in the TSN domain into consideration, aiming to provide a latency guarantee for time-triggered applications across 5G and TSN as well as a throughput guarantee for video applications in 5G systems. The simulation results compare the latency and throughput performance of the proposed joint scheduling algorithm with several traditional 5G scheduling algorithms; meanwhile, several GCL setting methods are given to verify the impacts on latency and throughput performance within the proposed algorithm. The simulation results demonstrate that the proposed DDPG-based joint scheduling algorithm can significantly enhance the multi-application-carrying capability of 5G-TSN collaboration architecture.
A Cross-Modality Person Re-Identification Method Based on Joint Middle Modality and Representation Learning
Authors: Ma Li , Guan Zhibin , Dai Xinguan , Gao Hangbiao , Lu Yuanmeng
Published: June 2023

Modality differences and intra-class differences have been hot research problems in the field of cross-modality person re-identification currently. In this paper, we propose a cross-modality person re-identification method based on joint middle modality and representation learning. To reduce the modality differences, a middle modal generator is used to map different modal images to a unified feature space to generate middle modality images. A two-stream network with parameter sharing is used to extract the combined features of the original image and the middle modality image. In addition, a multi-granularity pooling strategy combining global features and local features is used to improve the representation learning capability of the model and further reduce the modality differences. To reduce the intra-class differences, the model is further optimized by combining distribution consistency loss, label smoothing cross-entropy loss, and hetero-center triplet loss to reduce the intra-class distance and accelerate the model convergence. In this paper, we use the publicly available datasets RegDB and SYSU-MM01 for validation. The results show that the proposed approach in this paper reaches 68.11% mAP in All Search mode for the SYSU-MM01 dataset and 86.54% mAP in VtI mode for the RegDB dataset, with a performance improvement of 3.29% and 3.29%, respectively, which demonstrate the effectiveness of the proposed method.
MFLCES: Multi-Level Federated Edge Learning Algorithm Based on Client and Edge Server Selection
Authors: Liu Zhenpeng , Duan Sichen , Wang Shuo , Liu Yi , Li Xiaofei
Published: June 2023

This research suggests a multi-level federated edge learning algorithm by leveraging the advantages of Edge Computing Paradigm. Model aggregation is partially moved from a cloud center server to edge servers in this framework, and edge servers are connected hierarchically depending on where they are located and how much computational power they have. At the same time, we considered an important issue: the heterogeneity of different client computing resources (such as device processor computing power) and server communication channels (which may be limited by geography or device). For this situation, a client and edge server selection algorithm (CESA) based on a greedy algorithm is proposed in this paper. Given resource constraints, CESA aims to select as many clients and edge servers as possible to participate in the model computation in order to improve the accuracy of the model. The simulation results show that, when the number of clients is high, the multi-level federated edge learning algorithm can shorten the model training time and improve efficiency compared to the traditional federated learning algorithm. Meanwhile, the CESA is able to aggregate more clients for training in the same amount of time compared to the baseline algorithm, improving model training accuracy.
Improving Seed-Based FPGA Packing with Indirect Connection for Realization of Neural Networks
Authors: Yu Le , Guo Baojin , Zhi Tian , Bai Lida
Published: June 2023

FPGAs are gaining favor among researchers in fields including artificial intelligence and big data due to their configurability and high level of parallelism. As the packing methods indisputably affect the implementation performance of FPGA chips, packing techniques play an important role in the design automation flow of FPGAs. In this paper, we propose a quantitative rule for packing priority of neural network circuits, and optimize the traditional seed-based packing methods with special primitives. The experiment result indicates that the proposed packing method achieves an average decrease of 8.45% in critical path delay compared to the VTR8.0 on Koios deep learning benchmarks.
Entity Linking Method for Chinese Short Texts with Multiple Embedded Representations
Authors: Shi Yongqi , Yang Ruopeng , Yin Changsheng , Lu Yiwei , Yang Yuantao , Tao Yu
Published: June 2023

Entity linking, a crucial task in the realm of natural language processing, aims to link entity mentions in a text to their corresponding entities in the knowledge base. While long documents provide abundant contextual information, facilitating feature extraction for entity identification and disambiguation, entity linking in Chinese short texts presents significant challenges. This study introduces an innovative approach to entity linking within Chinese short texts, combining multiple embedding representations. It integrates embedding representations from both entities and relations in the knowledge graph triples, as well as embedding representations from the descriptive text of entities and relations, to enhance the performance of entity linking. The method also incorporates external semantic supplements to strengthen the model’s feature learning capabilities. The Multi-Embedding Representation–Bidirectional Encoder Representation from Transformers–Bidirectional Gated Recurrent Unit (MER-BERT-BiGRU) neural network model is employed for embedding learning. The precision, recall, and F1 scores reached 89.73%, 92.18%, and 90.94% respectively, demonstrating the effectiveness of our approach.
Benefits from Using Very Thin Channel Layer for TFTs
Authors: Samb Mamadou Lamine , Jacques Emmanuel , Maiga Amadou Seidou , Mohammed-Brahim Tayeb
Published: June 2023

It is known from many published data on amorphous or polycrystalline silicon and on metal oxides based Thin Film Transistors (TFTs) that their electrical parameters improve when decreasing the thickness of the channel layer. The origin of this improvement is discussed here through electrostatic arguments only. In particular, it is shown that the behavior of the subthreshold swing with the thickness does not depend on the type of materials. The material and its electrical defects determine only the importance of the improvement but not the trend towards better electrical parameters. Meanwhile, in general, the electrical stability under gate stress enhances too. The improved stability is explained by the reduced electronic charge inside the channel layer, leading to a lower injection of electrons in the gate insulator.
Attention Mechanisms in Convolutional Neural Networks for Nitrogen Treatment Detection in Tomato Leaves Using Hyperspectral Images
Authors: Benmouna Brahim , Pourdarbani Raziyeh , Sabzi Sajad , Fernandez-Beltran Ruben , García-Mateos Ginés , Molina-Martínez José Miguel
Published: June 2023

Nitrogen is an essential macronutrient for the growth and development of tomatoes. However, excess nitrogen fertilization can affect the quality of tomato fruit, making it unattractive to consumers. Consequently, the aim of this study is to develop a method for the early detection of excessive nitrogen fertilizer use in Royal tomato by visible and near-infrared spectroscopy. Spectral reflectance values of tomato leaves were captured at wavelengths between 400 and 1100 nm, collected from several treatments after application of normal nitrogen and on the first, second, and third days after application of excess nitrogen. A new method based on convolutional neural networks (CNN) with an attention mechanism was proposed to perform the estimation of nitrogen overdose in tomato leaves. To verify the effectiveness of this method, the proposed attention mechanism-based CNN classifier was compared with an alternative CNN having the same architecture without integrating the attention mechanism, and with other CNN models, AlexNet and VGGNet. Experimental results showed that the CNN with an attention mechanism outperformed the alternative CNN, achieving a correct classification rate (CCR) of 97.33% for the treatment, compared with a CCR of 94.94% for the CNN alone. These findings will help in the development of a new tool for rapid and accurate detection of nitrogen fertilizer overuse in large areas.
Mechanistic Study of the Synergistic Interaction of Furfuryl Alcohol and Caprolactam in the Modification of Pinus massoniana Earlywood and Latewood
Authors: Wang Ziheng , He Sheng , Shi Jiangtao , Zhang Xuefeng , Leng Weiqi
Published: June 2023

Furfurylated wood has many advantages, such as decay resistance, dimensional stability, hardness, etc. However, furfurylation increases the brittleness and decreases the flexural resistance of wood, which greatly limits its application. Therefore, caprolactam (CPL) is incorporated with furfuryl alcohol (FA) to improve the performance of furfurylated wood. In this study, an FA and CPL combinational modifier was used to treat masson pine (Pinus massoniana Lamb.) earlywood and latewood. The synergistic interaction of both components with the wood cell walls was systematically evaluated via microstructural, chemical, and thermal analysis using scanning electron microscopy (SEM), infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectrometry (XPS), and differential scanning calorimetry (DSC). The SEM images showed that polymerized modifiers were distributed in tracheids, ray cells, and pits, with a higher degree of distribution in latewood tissues. The FA-CPL co-treatment led to the highest degree of distribution in cell cavities as well as of cell wall swelling. The results of the weight percentage gain (WPG) of modified wood agreed with the SEM findings that the FA-CPL co-treatment could more effectively increase the WPG than individual modification. The results of FTIR and XPS revealed that FA and CPL might chemically bind with each other as well as react with lignin and hemicellulose in the cell walls during the curing process. In addition, the interactions between modifiers and cell walls were slightly different for earlywood and latewood. DSC analysis indicated that the wood hygroscopicity decreased and the thermal stability improved after modification.
Correlation and Community Stability Analysis of Herbaceous Plants in Dashiwei Tiankeng Group, China
Authors: Chen Ming , Mo Fuyan , Zheng Lili , Bin Guoliang , Zou Ziyu , Chen Peiqi , Xue Yuegui
Published: June 2023

Studying the interspecific association and stability of herbaceous communities in different developmental stages of tiankeng is helpful to understand the relationship between tiankeng vegetation and the environment, and can provide an important theoretical basis for the protection and restoration of the karst tiankeng ecosystem. In this study, the herbaceous community of the Dashiwei Tiankeng Group in Guangxi was studied to analyze the interspecific relationships and community stability of herbaceous plants in four different habitats (the earlier stage, middle stage, late stage and the external forest of tiankeng), and to explore whether the herbaceous community structure gradually stabilized with the development of tiankeng. The variance ratio (VR), X2 test, association coefficient (JI) and the Spearman rank correlation coefficient test were used to analyze the interspecific association of the main herbaceous plants in different developmental stages of tiankeng. The stability of the herbaceous community was analyzed by the stability measurement method of M. Godron. The results showed that: (1) the logarithm of the middle stage of tiankeng negatively correlated species was the highest (56.7%), and the logarithm of the later stage of tiankeng positively correlated species was the highest (57.2%). The positive and negative correlation ratio of main herbs decreased first and then increased, indicating that the middle stage of development was the period of high competition among herbs and the biggest difference in resource utilization. The ecological habits of herbaceous plants will be changed from sciophiles to hygrophytes to heliophiles and drought-enduring plants. (2) The earlier stage and middle stage of tiankeng overall relevance had a significant negative correlation, the later stage and external forest of tiankeng overall correlation were not significant positive correlation, and the X2 test and the Spearman rank correlation coefficient of different developmental stages of tiankeng most major herbaceous species were not significant correlation, suggesting that the major herbs in tiankengs had weak association and strong independence. (3) The distance from the intersection point to the stable point (20, 80) was 19.799, 17.867, 18.922 and 17.706, respectively, of the four regression models of tiankengs herb community, which further indicated that the forest herb layers were in an unstable state. The forest outside is relatively more stable than the herbaceous community inside the tiankeng.
A Composite Whole-Biomass Tannin–Sucrose–Soy Protein Wood Adhesive with High Performance
Authors: Xiao Guoming , Liang Jiankun , Wu Zhigang , Lei Hong , Gong Feiyan , Gu Wen , Tu Yuan , Li De
Published: June 2023

Whole-biomass adhesives are the research hotspot of wood adhesives andcan improve the competitiveness of adhesives. The tannin–sucrose adhesive studied by our research group shows good bonding performance, but poor bonding stability induced by low viscosity. In this study, the tannin–sucrose adhesive was modified by isolated soybean protein (SPI), the effect of the SPI substitution ratio for tannin on the properties of the tannin–sucrose–SPI composite adhesive was investigated, and the bonding mechanism was explored using Fourier-transform infrared spectroscopy (FT-IR), thermogravimetry (TG), X-ray diffraction (XRD), and gas chromatography–mass spectroscopy (GC–MS). The results showed that: (1) when the SPI substitution ratio was above 40%, the viscosity of the composite adhesive increased significantly, which effectively avoided adhesive leakage. (2) The tannin–sucrose–SPI composite adhesive displayed high bonding performance and water resistance. (3) The FTIR and GC–MS results revealed that the curing mechanism of the tannin–sucrose–SPI adhesive was very complicated, but it was certain that the conversion of sucrose into furan compounds, especially 5-hydroxymethylfurfural (5-HMF), was the core of the cross-linking reaction of the adhesive when elevating temperature. (4) The macromolecules and high reactivity of SPI compensated for the shortage of high temperature required for the conversion of sucrose into furanic cross-linkers so that the tannin–sucrose–SPI adhesive experienced an efficient curing reaction at a low temperature, and the reaction degree and thermal stability of the curing product increased.
Assessing the Sustainability of NTFP-Based Community Enterprises: A Viable Business Model for Indonesian Rural Forested Areas
Authors: Harbi Jun , Cao Yukun , Milantara Noril , Mustafa Ade Brian
Published: June 2023

Indonesia’s vast forested areas have the potential to serve as a crucial source of livelihood for local communities. However, the current contributions of these forests to community livelihoods are significantly underutilized in comparison to their potential. This study evaluates the financial performance and sustainability of community forest-based businesses operating around the forest management area of the Lakitan-Bukit Cogong forest management unit (LBC FMU). Data were collected through semi-structured and in-depth interviews with the key informants through purposive sampling. Financial viability analysis and a qualitative approach were used to assess the feasibility of the businesses. The findings revealed that all businesses show positive values for all financial indicators. From profit estimation and value-added distribution, all products are shown to be feasible. Concerning the value and supply chain, the rubber-processing industry has a remarkable flow. Moreover, small forest enterprises (SFEs) highlight natural capital optimization through multitudinous derivatives of products that could support a substantial regenerative economy, including citronella essential oil, native honeybees, rubber-based product, biochar, skewers, and liquid smoke. In addition, the multidimensional scaling and rapid appraisal for forest (MDS-RAPForest) approach generates a result based on multiple dimensions (ecology, economics, social and human resources, and institutional and administrative dimensions) showing that overall, SFEs are categorized as sufficient/quite sustainable. Furthermore, mainstreaming adaptable forest-based enterprises, jurisdiction approaches, and cross-production system strategies are also discussed. Our findings suggest that sustainable NTFP-based activities within a community context can be facilitated through interconnected market systems, appropriate price regulations, and support from stakeholders and legal frameworks.
Research on the Estimation of Chinese Fir Stand Volume Based on UAV-LiDAR Technology
Authors: Yu Shuhan , Chen Xiangyu , Huang Xiang , Chen Yichen , Hu Zhongyang , Liu Jian , Yu Kunyong
Published: June 2023

Chinese fir (Cunninghamia lanceolata) is the main fast-growing timber species in China, and studies of its stand volume are important for evaluating the effectiveness of forest management. However, it is difficult to accurately estimate stand volume from the perspective of a single tree due to the mutual concealment among Chinese fir trees. Therefore, in this study, we propose a method for identifying different forms of Chinese fir. The specific idea is to realize the accurate identification of a single Chinese fir tree, two Chinese fir trees, and three Chinese fir trees, and construct their respective stand volume estimation models to obtain an estimate of the forest stand volume. The key results are as follows: (1) the overall accuracy of recognition of different forms of Chinese fir is 79%, and the construction of different forms of Chinese fir units is beneficial for identifying forest trees; (2) a multiunit volume equation for different forms of Chinese fir is constructed; (3) based on predictions obtained with the constructed stand volume model, the difference between the estimated stand volume and the measured stand volume is small, and the average accuracy reaches 89.19%; and (4) compared to traditional volume estimation methods based on individual tree scale, the research method in this study shows a significant improvement (about 9.96%) in overall accuracy. In summary, this method can weaken the influence of erroneous individual tree segmentation on the accuracy of stand volume estimation, and can greatly reduce the working time of single tree segmentation to achieve the fast and accurate estimation of fir plantation stand volume.
Decomposition and Nutrient Release from Larix olgensis Stumps and Coarse Roots in Northeast China 33-Year Chronosequence Study
Authors: Men Xiuli , Yue Yang , Wang Xiuwei , Chen Xiangwei
Published: June 2023

Stumps and coarse roots form an important C pool and nutrient pool in a Larix olgensis (Larix olgensis Henry) plantation ecosystem, and their decomposition processes would affect nutrient cycling dynamics of the overall Larix olgensis plantation. We studied the decomposition and release of nutrients from stumps and coarse roots that were cleared 0, 6, 16, 26 and 33 years ago in Northeast China. The stumps and coarse roots were divided into stump discs (SD), stump knots (SK), coarse roots (>10 cm in diameter) (CR1), medium-coarse roots (5–10 cm in diameter) (CR2) and fine-coarse roots (2–5 cm in diameter) (CR3). During the entire 33-year study period, SK, CR1, CR2 and CR3 lost 87.37%, 96.24%, 75.76% and 91.98% of their initial mass, respectively. The average annual decomposition rate (k) was 0.068 for SD, 0.052 for SK, 0.092 for CR1, 0.068 for CR2 and 0.066 for CR3. After 33 years of decomposition, CR3 lost 5% of its initial C, CR2 lost 2%, and SK accumulated 1%, indicating slow C release. The N residues in SK, CR1, CR2 and CR3 were 186%, 109%, 158% and 170%, respectively. Coarse roots released P significantly faster than SD and SK, with 13% of the initial P released in CR1. SD and SK release cellulose, hemicellulose and lignin faster than coarse roots. The results show that Larix olgensis stumps and coarse roots could contribute to soil fertility recovery and serve as a long-term nutrient reservoir for forest vegetation.
High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients
Authors: Azambuja Daniel , e Gloria Helena , Montenegro Gabriel , Kalil Antonio , Hoffmann Jean-Sébastien , Leguisamo Natalia , Saffi Jenifer
Published: June 2023

Background: Homologous recombination repair (HR) is the most accurate repair pathway for double-strand breaks and replication fork disruption that is capable of faithfully restoring the original nucleotide sequence of the broken DNA. The deficiency of this mechanism is a frequent event in tumorigenesis. Therapies that exploit defects in HR have been explored essentially in breast, ovarian, pancreatic, and prostate cancers, but poorly in colorectal cancers (CRC), although CRC ranks second in mortality worldwide. Methods: Tumor specimens and matched healthy tissues from 63 patients with CRC were assessed for gene expression of key HR components and mismatch repair (MMR) status, which correlated with clinicopathological features, progression-free survival, and overall survival (OS). Results: Enhanced expression of MRE11 homolog (MRE11A), the gene encoding a key molecular actor for resection, is significantly overexpressed in CRC, is associated with the occurrence of primary tumors, particularly T3-T4, and is found in more than 90% of the right-side of CRC, the location with the worst prognosis. Importantly, we also found that high MRE11A transcript abundance is associated with 16.7 months shorter OS and a 3.5 higher risk of death. Conclusion: Monitoring of MRE11 expression could be used both as a predictor of outcome and as a marker to select CRC patients for treatments thus far adapted for HR-deficient cancers.
Genome-Wide Identification of the WD40 Gene Family in Tomato (Solanum lycopersicum L.)
Authors: Yan Cunyao , Yang Tao , Wang Baike , Yang Haitao , Wang Juan , Yu Qinghui
Published: June 2023

WD40 proteins are a superfamily of regulatory proteins widely found in eukaryotes that play an important role in regulating plant growth and development. However, the systematic identification and characterization of WD40 proteins in tomato (Solanum lycopersicum L.) have not been reported. In the present study, we identified 207 WD40 genes in the tomatoes genome and analyzed their chromosomal location, gene structure and evolutionary relationships. A total of 207 tomato WD40 genes were classified by structural domain and phylogenetic tree analyses into five clusters and 12 subfamilies and were found to be unevenly distributed across the 12 tomato chromosomes. We identified six tandem duplication gene pairs and 24 segmental duplication pairs in the WD40 gene family, with segmental duplication being the major mode of expansion in tomatoes. Ka/Ks analysis revealed that paralogs and orthologs of WD40 family genes underwent mainly purifying selection during the evolutionary process. RNA-seq data from different tissues and developmental periods of tomato fruit development showed tissue-specific expression of WD40 genes. In addition, we constructed four coexpression networks according to the transcriptome and metabolome data for WD40 proteins involved in fruit development that may be related to total soluble solid formation. The results provide a comprehensive overview of the tomato WD40 gene family and will provide valuable information for the validation of the function of tomato WD40 genes in fruit development.
The Role of Death-Associated Protein Kinase-1 in Cell Homeostasis-Related Processes
Authors: Makgoo Lilian , Mosebi Salerwe , Mbita Zukile
Published: June 2023

Tremendous amount of financial resources and manpower have been invested to understand the function of numerous genes that are deregulated during the carcinogenesis process, which can be targeted for anticancer therapeutic interventions. Death-associated protein kinase 1 (DAPK-1) is one of the genes that have shown potential as biomarkers for cancer treatment. It is a member of the kinase family, which also includes Death-associated protein kinase 2 (DAPK-2), Death-associated protein kinase 3 (DAPK-3), Death-associated protein kinase-related apoptosis-inducing kinase 1 (DRAK-1) and Death-associated protein kinase-related apoptosis-inducing kinase 2 (DRAK-2). DAPK-1 is a tumour-suppressor gene that is hypermethylated in most human cancers. Additionally, DAPK-1 regulates a number of cellular processes, including apoptosis, autophagy and the cell cycle. The molecular basis by which DAPK-1 induces these cell homeostasis-related processes for cancer prevention is less understood; hence, they need to be investigated. The purpose of this review is to discuss the current understanding of the mechanisms of DAPK-1 in cell homeostasis-related processes, especially apoptosis, autophagy and the cell cycle. It also explores how the expression of DAPK-1 affects carcinogenesis. Since deregulation of DAPK-1 is implicated in the pathogenesis of cancer, altering DAPK-1 expression or activity may be a promising therapeutic strategy against cancer.