bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Pembuatan Yogurt Untuk Kader Posyandu “Kamboja” Kelurahan Tasikmadu
Authors: Hendrawati Nanik , Profiyanti Hermien Suharti  , Hadi Saroso  , Agung Ari Wibowo
Published: December 2022

Posyandu Kamboja berdiri pada tahun 1975 di RW 4 Kelurahan Tasikmadu Kecamatan Lowokwaru. Nama ketua kader Posyandu tersebut adalah Ibu Jumik Rahayu, dengan jumlah kader sebanyak 13 orang. Kegiatan taman posyandu kamboja meliputi posyandu, Bina Keluarga Balita (BKB), dan pos Paud. Penyuluhan makanan bergizi merupakan salah satu kegiatan utama dan umumnya menjadi prioritas dalam pelaksanaan kegiatan Posyandu. Peran aktif kader kesehatan dipelayanan gizi sangat penting untuk meningkatkan kualitas dan status gizi masyarakat terutama kesehatan ibu dan anak. Permasalahan mendasar dari kader posyandu antara lain terbatasnya pengetahuan pengetahuan mengenai kecukupan makanan bergizi 2. Belum memiliki keterampilan teknik mengolah produk susu bernilai ekonomis dan bergizi. 3. Pendidikan kader posyandu yang masih kurang, rata-rata lulusan SMP dan SMA. Adapun Solusi yang ditawarkan tim PKM Polinema untuk mengatasi permasalahan mitra antara lai (1) Pelatihan serta pendampingan pembuatan yogurt sebagai solusi keterbatasan ketrampilan dari binaan kader posyandu “Kamboja” lowokwaru, 2) Pelatihan serta pendampingan keterampilan diversifikasi produk olahan Susu yang bernilai ekonomis dan bergizi tinggi. Kegiatan pelatihan pembuatan yogurt dilaksanakan pada tanggal 11 September 2021 bertempat di gedung balai RW 04 kelurahan Tasikmadu. Metode yang digunakan dalam pengabdian ini adalah metode ceramah, diskusi, demonstrasi, tanya jawab dan pelaksanaan tugas.
Pelatihan Pemanfaatan Sistem Informasi Pondok Pesantren Ashabul Kahfi
Authors: Saputra Pramana Yoga , Rawansyah  , Ulla Delfana Rosiani  , Ariadi Retno Ririd  , Noprianto
Published: December 2022

Pondok Pesantren Ashabul Kahfi Malang merupakan sebuah pondok pesantren yang diperuntukkan bagi mahasiswa yang berdiri sejak tahun 1995. Terletak pada jalan Semanggi Barat no 1A Lowokwaru Malang. Pondok Pesantren Ashabul Kahfi masih menerapkan sistem pengadministrasian yang sederhana dibantu dengan buku besar serta komputerisasi sederhana. Melihat banyaknya santri yang terus bertambah, hal tersebut menyulitkan pengurus yang bertugas absensi waktu talim. Sehingga perlu adanya sistem informasi yang dapat digunakan untuk mengurangi permasalahan yang ada, serta membantu dan mempermudah pengurus. Agar pihak pengurus Pondok Pesantren Ashabul Kahfi Malang dapat memahami alur serta pengoperasian sistem informasi yang ada, maka perlu dilakukan sosialisasi dan pelatihan pemanfaatan sistem informasi tersebut. Sehingga proses bisnis yang ada di Pondok Pesantren Ashabul Kahfi Malang dapat berjalan dengan lancar.
Pelatihan Teknologi Informasi Pemograman Web Pada Panti Asuhan Al Husna Malang Dalam Menghadapi Era Digital
Authors: Mochammad Junus  , Septriandi Wira Yoga  , Galih Putra Riatma  , Rieke Adriati Wijayanti
Published: December 2022

Panti asuhan merupakan sebuah lembaga usaha kesejahteraan sosial yang mempunyai tanggung jawab untuk memberikan pelayanan kesejahteraan sosial kepada anak telantar dengan melaksanakan penyantunan dan pengentasan anak telantar, memberikan pelayanan pengganti fisik, mental, dan sosial pada anak asuh, sehingga memperoleh kesempatan yang luas, tepat dan memadai bagi perkembangan kepribadiannya sesuai dengan yang diharapkan sebagai bagian dari generasi penerus cita-cita bangsa dan sebagai insan yang akan turut serta aktif di dalam bidang pembangunan nasional. Tetapi pada kondisinya saat ini, banyak anak anak dari panti asuhan yang belum terjangkau oleh pengetahuan teknologi karena sedikitnya ilmu yang diterima pada bidang tersebut. Salah satunya adalah Panti Asuhan Al Husna di Kabupaten Malang. Dalam hasil pengabdian yang dilakukan pada lokasi yang di tetapkan, peserta pria lebih baik dalam menyerap materi yang diberikan daripada peserta wanita bailk dalam hal pelatihan pembuatan web yang dirancang pada pengabdian ini. Diharapkan setelah pelatihan ini para anak anak di Panti Asuhan Al Husna Kabupaten Malang mampu ikut bersaing secara global melalui media website
Workshop Penerapan Green Energy Berbasis Rooftop Solar Photovoltaic Pada UMKM Maju Lancar Kota Madiun
Authors: Awan Setiawan  , Rohmanita Duanaputri  , Imron Ridzki  , Irwan Heryanto  , Rahman Azis Prasojo  , Hanifiyah Darna Fidya Amaral
Published: December 2022

Indonesia adalah salah satu negara beriklim tropis serta negara yang dilalui oleh garis khatulistiwa seluruh wilayahnya mendapatkan sinar matahari yang cukup besar sepanjang tahun sehingga dapat dikembangkan energi terbarukan. Untuk meningkatkan ketersediaan energi listrik berkelanjutan secara maksimal, penggunaan PLTS rooftop skala kecil dapat menjadi solusi sebagai sumber energi listrik ketika sumber PLN padam. Dalam membuat perencanaan sistem green energy dengan PLTS perlu dilakukan analisis terlebih dahulu, dimana analisis yang dilakukan bertujuan untuk mengetahui kinerja dari sistem yang telah direncanakan agar sistem dapat bekerja secara maksimal sehingga ketersediaan energi listrik yang dibutuhkan oleh beban dapat terpenuhi. Perencanaan dan analisis tersebut juga dapat dijadikan tolak ukur untuk membuat perencanaan dengan skala besar kedepannya. Metode penelitian ini dilakukan dengan uji coba dan pengambilan data dari peralatan sistem rooftop solar photovoltaic. Pada saat pengujian dilakukan dengan menggunakan sudut kemiringan 13° dan simulasi shading pada modul photovoltaic 3x100Wp monocrystalline dengan sistem pemasangan paralel sehingga didapatkan data pengukuran dari sistem yang telah dibuat. Dari hasil uji coba dan analisis yang dilakukan bahwa kinerja dari sistem backup supply menghasilkan energi harian yang lebih besar daripada energi yang dibutuhkan beban, dengan PSH (Peak Sun Hours) selama 5 jam penyinaran. Economy feasibility dari pemasangan rooftop solar photovoltaic ditinjau dari segi techno-economic dengan menggunakan metode diperoleh Net Present Value (NPV) Rp16.383,98, Profitability Index (PI) 1,002, Internal Rate of Return (IRR) 4,53% dan payback period 20 tahun maka berdasarkan kriteria standar pemasangan sistem ini dinilai layak.
Pelatihan Pembuatan Kontrol Pompa Tandon di Perumahan Giripalma Desa Karangwidoro Dau Malang
Authors: Tresna Umar Syamsuri  , Rohmanita Duanaputri  , Harrij Mukti K.  , Rahma Nur Amalia  , Ruwah Joto
Published: December 2022

Perumahan Giripalma mempunyai sumur air yang dikelola sendiri oleh warga Perumahan. Penggunaan air dari sumur ini berbayar atau dengan kata lain warga Perumahan berlanggan. Warga berlangganan dimaksudkan agar pemakaian air tidak boros, dengan demikian diharapkan agar sumur tidak cepat habis airnya. Air dari sumur ini dinaikan ke tandon dengan menggunakan motor pompa listrik tiga fasa 380V. Sampai saat ini motor pompa dihidupkan dan dimatikan dengan cara manual, yaitu apabila apabila air di tandon sudah habis maka pompa dihidupkan, sampai tandon air penuh. Ada petugas sendiri yang menghidupkan dan yang mematikan pompa. Kelemahan dari cara manual ini, petugas sering bolak-balik untuk melihat apakah tandon sudah penuh atau belum, karena kalau tandon ditunggu sampai penuh maka butuh waktu lama, padahal dengan waktu yang lama ini petugas bisa mengerjakan pekerjaan yang lain.Untuk memudahkan dan meringkankan pekerjaan petugan maka kami membuat kontrol pompa air ini secara otomatis, yaitu apabila tandon kosong maka otomatis pompa bekerja, dan apabila tandon penuh pompa maka berhenti. Selanjutnya untuk memantau kontrol pompa air ini tidak dipercayakan kepada petugas lagi tetapi dipercayakan kepada Karang Taruna Perumahan Giripalma, agar Karang Taruna bertanggungjawab terhadap lingkungan hidupnya, dan untuk kerampilan mereka di masa mendatang.
Pelatihan Dan Pembuatan Mesin Pencacah Rumput Konstruksi Kayu Untuk Pengolahan Pakan Ternak Kambing Di Desa Pakis Kecamatan Durenan
Authors: Mashudi Imam , Fakhruddin Muhammad , Hardjito Agus , Muzaki Mochamad , Faizal Elka , Harijono Agus
Published: December 2022

Potensi sumber alam di lingkungan sekitar berupa ketersediaan sumber makanan kambing yang melimpah RT04/RW2, Desa Pakis, Kecamatan Durenan, Kabupaten Trenggalek, telah mulai dimanfaatkan oleh mitra untuk usaha pemeliharaan kambing sebagai upaya dalam meningkatkan kemampuan ekonomi rumah tangga. Dari proses pemeliharaan yang baik dan ketersediaan sumber makanan yang melimpah, sampai dengan sekarang sudah berhasil dibudidayakan 12 ekor kambing yang masuk pada katagori peternakan kambing skala mikro. Usaha ini cukup memberikan kontribusi yang baik untuk meningkatkan kondisi perekonomian keluarga dalam memenuhi kebutuhannya. Dalam perjalanannya, dalam menekuni usaha ini, ditemui kendala utama yang menghambat kemajuan dari usaha ini, yaitu kendala kurang idealnya pencacah rumput yang ada untuk dapat mendukung keberhasilan usaha tsb. Kegiatan yang menyita cukup banyak waktu untuk mencukupi kebutuhan pakan kambing yang disebut tiada hari tanpa ngarit (mencari pakan) menjadi kendala utama. Kondisi ini memberikan kesempatan yang sempit bagi mitra untuk memikirkan merintis dan merealisasikan usaha-usaha baru lainnya atau untuk berpatisipasi dalam kegiatan sosial lainnya. Sebagai solusinya kepada mitra diberikan pelatihan untuk membuat mesin pencacah kecil, sederhana, murah, terbuat dari konstruksi utama kayu yang mampu memenuhi kebutuhan pengolahan pengawetan sebagian pakan ternak kambingnya yang nantinya dapat dipakankan pada waktu yang dapat dijadwalkan. Dengan itu, mitra dapat memiliki waktu luang untuk dapat meiliki peluang yang lebih besar untuk memikirkan dan merealisasikan rintisan usaha laian atau paling tidak mitra memiliki waktu yang lebih leluasa untuk keluarga. Sebagai solusinya kepada mitra diberikan pelatihan untuk merancang dan membuat pencacah rumput yang ideal dengan mengacu kepada konsep desain yang kompak dan hemat daya serta memberikan manfaat pada kemudahan penggunaannya.
Pelatihan Kemasan Produk Anyaman Bambu Untuk Pengaruh Display Produk Dalam Promosi Terhadap Pembelian Konsumen Di Desa Duwet Kecamatan Tumpang Kabupaten Malang
Authors: Putra Prima Arhandi  , Annisa Taufika Firdausi  , Kadek Suarjuna Batubulan  , Rosa Andrie Asmara  , Banni Satria Andoko  , Dian Hanifudin Subhi
Published: December 2022

Disaat pandemi Covid-19 yang menerjang Indonesia menjadikan ekonomi berpengaruh sehingga menurun sangat signifikan bahkan sebagian besar kelas menengah kebawah yang sangat dirugikan contohnya UMKM annyaman bambu di desa Duwet. Dari pemasalahan tersebut penjualan masyarakat di Desa tersebut sangatlah kurang karena tidak adanya pemasukan yang menghasilkan bagi mereka apalagi dengan peraturan pemerintah yang sering berubah-berubah. Untuk dapat mengatasi permasalahan yang ada maka ini bisa memberikan solusi dengan cara memberikan sosialisasi dan pelatihan didalam Display Produk ke etalase yang diberikan. Selanjutnya dibuatkan etalase yang sesuai dengan yang dibutuhkan dan dapat memberikan kesan menarik didalam display produk sehingga ada beberapa desain etalase yang memang beda dengan yang lain, contoh ada kaca cermin untuk memberi kesan menarik didalam menaruh anyaman bambu. Kemudian setelah penyerahan etalase yaitu memberikan sosialisasi dan pelatihan didalam beberapa model display produk dari berbagai sumber untuk penerapannya. selanjutnya dibuatkan pengujian kepuasan masyarakat sesuai dengan yang diberikan kepada para user dengan cara kuisioner. Dari hasil pengujian maka dapat diambil keputusan bahwa dari 20 user yang mengikuti sosialisasi tersebut ada beberapa warga yang kurang sesui dikarenakan beberapa anyaman bambu yang akan diimplementasikan masih dibawa untuk pameran di tempat lain sesuai dengan kebutuhan tetapi dari hasil untuk sosialisasi ini hampir keseluruhan setuju karena dapat memberikan hasil yang bermanfaat dan diharapkan mampu memberikan hasil jual yang lebih baik.
Intervention of Progressive Muscle Relaxation on Anxiety and Sleep Quality in COVID-19 Patients : A Systematic Review
Authors: Nurul Imam  , Alfian Bayu Indrawan  , Rofi Syahrizal  , Shafaat Pranata
Published: December 2022

COVID-19 is an infectious disease. COVID-19 patients will experience anxiety, thus disturbing the patient's sleep quality. Pharmacological therapy given in the long term poses a risk to the health of the body. This study aims to determine the effectiveness of progressive muscle relaxation in COVID-19 patients to reduce anxiety and improve sleep quality. The studies were identified systematic by searching the database with the keywords “COVID-19 AND Anxiety AND Sleep Quality AND progressive Muscle Relaxation.” The results consist of Web of Science 3 articles, Scopus 3 articles, Science Direct 135 and Pro Quest 501 articles. Eligible articles were selected according to the inclusion and exclusion criteria, COVID-19 patients with anxiety and sleep disturbances as well as with PMR intervention and articles published in English based on the last 3 years study. In assessing the bias and methodological quality of this study using the Joanna Briggs Institute (JBI) critical appraisal checklist tool. From 642 references, after a selection there were 5 references describing in detail progressive muscle relaxation exercises that could be used together with pharmacological during treatment in isolation rooms. Progressive muscle relaxation exercises are performed 2 times a day, in the morning and before going to bed, with a duration of 20-30 minutes. Progressive muscle relaxation significant reduces anxiety and improves sleep quality in COVID-19 patients during isolation treatment.
Determinan Kejadian Stunting di Wilayah Kerja Dinas Kesehatan Kabupaten Lampung Utara
Authors: Jayanti Novi , Irianto Sugeng Eko , Kustiani Ai , Rahayu Dewi , Adyas Atikah
Published: December 2022

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berhubungan dengan kejadian Stunting di wilayah kerja dinas kesehatan kabupaten lampung utara tahun 2021. Desain penelitian yang digunakan adalah analitik cross sectional, subjek dalam penelitian ini adalah ibu dengan balita yang ada di Kabupaten Lampung Utara. Sampel yang digunakan sebanyak 100 responden dengan teknik pengambilan sampel menggunakan teknik purposive sampling. Analisis dalam penelitian ini menggunakan chi-square dan regresi logistik berganda. Hasil penelitian yaitu terdapat  26% balita yang Stunting. Balita asupan gizinya cukup sebesar 57%, persentase balita yang memiliki riwayat penyakit infeksi sebesar 29%, pemberian ASI Eksklusif sebesar 70%, terdapat 27% yang tidak menerima imunisasi dasar, Pendidikan ibu dengan kategori tinggi yaitu 73%, dan pendapatan keluarga dengan kategori tinggi yaitu 72%, dan terdapat 24% balita yang tidak mendapatkan layanan kesehatan, serta sanita lingkungan dengan kategori buruk sebesar 28%.. Hasil uji statistik didapatkan bahwa ada hubungan antara asupan gizi (p=0,000), penyakit infeksi (p=0,000), Riwayat Pemberian ASI Eksklusif (p= 0,000), imunisasi dasar (p=0,000), Pendidikan ibu (p=0,001), pendapatan keluarga (p=0,015), pelayanan Kesehatan (p=0,000), dan sanitasi lingkungan (p=0,000) dengan kejadian stunting. Pada analisis multivariat didapatkan faktor yang paling dominan adalah sanitasi lingkungan dengan p-value 0,001 dengan OR terbesar yaitu 28,540
A plasmid-free Zymomonas mobilis mutant strain reducing reactive oxygen species for efficient bioethanol production using industrial effluent of xylose mother liquor
Authors: Geng Binan , Liu Shuyi , Chen Yunhao , Wu Yalun , Wang Yi , Zhou Xuan , Li Han , Li Mian , Yang Shihui
Published: December 2022

Genome minimization is an effective way for industrial chassis development. In this study, Zymomonas mobilis ZMNP, a plasmid-free mutant strain of Z. mobilis ZM4 with four native plasmids deleted, was constructed using native type I-F CRISPR-Cas system. Cell growth of ZMNP under different temperatures and industrial effluent of xylose mother liquor were examined to investigate the impact of native plasmid removal. Despite ZMNP grew similarly as ZM4 under different temperatures, ZMNP had better xylose mother liquor utilization than ZM4. In addition, genomic, transcriptomic, and proteomic analyses were applied to unravel the molecular changes between ZM4 and ZMNP. Whole-genome resequencing result indicated that an S267P mutation in the C-terminal of OxyR, a peroxide-sensing transcriptional regulator, probably alters the transcription initiation of antioxidant genes for stress responses. Transcriptomic and proteomic studies illustrated that the reason that ZMNP utilized the toxic xylose mother liquor better than ZM4 was probably due to the upregulation of genes in ZMNP involving in stress responses as well as cysteine biosynthesis to accelerate the intracellular ROS detoxification and nucleic acid damage repair. This was further confirmed by lower ROS levels in ZMNP compared to ZM4 in different media supplemented with furfural or ethanol. The upregulation of stress response genes due to the OxyR mutation to accelerate ROS detoxification and DNA/RNA repair not only illustrates the underlying mechanism of the robustness of ZMNP in the toxic xylose mother liquor, but also provides an idea for the rational design of synthetic inhibitor-tolerant microorganisms for economic lignocellulosic biochemical production.
Understanding laterality disorders and the left-right organizer: Insights from zebrafish
Authors: Forrest Kadeen , Barricella Alexandria C. , Pohar Sonny A. , Hinman Anna Maria , Amack Jeffrey D.
Published: December 2022

Vital internal organs display a left-right (LR) asymmetric arrangement that is established during embryonic development. Disruption of this LR asymmetry—or laterality—can result in congenital organ malformations. Situs inversus totalis (SIT) is a complete concordant reversal of internal organs that results in a low occurrence of clinical consequences. Situs ambiguous, which gives rise to Heterotaxy syndrome (HTX), is characterized by discordant development and arrangement of organs that is associated with a wide range of birth defects. The leading cause of health problems in HTX patients is a congenital heart malformation. Mutations identified in patients with laterality disorders implicate motile cilia in establishing LR asymmetry. However, the cellular and molecular mechanisms underlying SIT and HTX are not fully understood. In several vertebrates, including mouse, frog and zebrafish, motile cilia located in a “left-right organizer” (LRO) trigger conserved signaling pathways that guide asymmetric organ development. Perturbation of LRO formation and/or function in animal models recapitulates organ malformations observed in SIT and HTX patients. This provides an opportunity to use these models to investigate the embryological origins of laterality disorders. The zebrafish embryo has emerged as an important model for investigating the earliest steps of LRO development. Here, we discuss clinical characteristics of human laterality disorders, and highlight experimental results from zebrafish that provide insights into LRO biology and advance our understanding of human laterality disorders.
Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression
Authors: Ahangar Davoodi Nasrin , Najafi Sajad , Naderi Ghale-Noie Zari , Piranviseh Ashkan , Mollazadeh Samaneh , Ahmadi Asouri Sahar , Asemi Zatollah , Morshedi Mohammadamin , Tamehri Zadeh Seyed Saeed , Hamblin Michael R. , Sheida Amirhossein , Mirzaei Hamed
Published: December 2022

Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the potential to affect vision, and can even be fatal in some children. While the tumor can be controlled efficiently at early stages, metastatic tumors lead to high mortality. Non-coding RNAs (ncRNAs) are implicated in a number of physiological cellular process, including differentiation, proliferation, migration, and invasion, The deregulation of ncRNAs is correlated with several diseases, particularly cancer. ncRNAs are categorized into two main groups based on their length, i.e. short and long ncRNAs. Moreover, ncRNA deregulation has been demonstrated to play a role in the pathogenesis and development of RB. Several ncRNAs, such as miR-491-3p, miR-613,and SUSD2 have been found to act as tumor suppressor genes in RB, but other ncRNAs, such as circ-E2F3, NEAT1, and TUG1 act as tumor promoter genes. Understanding the regulatory mechanisms of ncRNAs can provide new opportunities for RB therapy. In the present review, we discuss the functional roles of the most important ncRNAs in RB, their interaction with the genes responsible for RB initiation and progression, and possible future clinical applications as diagnostic and prognostic tools or as therapeutic targets.
A loop-mediated isothermal amplification-enabled analytical assay for the detection of SARS-CoV-2: A review
Authors: Li Mingna , Ge Hongjuan , Sun Zhe , Fu Jangshan , Cao Lele , Feng Xinrui , Meng Guixian , Peng Yubo , Liu Yan , Zhao Chen
Published: December 2022

The number of words: 4645, the number of figures: 4, the number of tables: 1The outbreak of COVID-19 in December 2019 caused a global pandemic of acute respiratory disease, and with the increasing virulence of mutant strains and the number of confirmed cases, this has resulted in a tremendous threat to global public health. Therefore, an accurate diagnosis of COVID-19 is urgently needed for rapid control of SARS-CoV-2 transmission. As a new molecular biology technology, loop-mediated isothermal amplification (LAMP) has the advantages of convenient operation, speed, low cost and high sensitivity and specificity. In the past two years, rampant COVID-19 and the continuous variation in the virus strains have demanded higher requirements for the rapid detection of pathogens. Compared with conventional RT–PCR and real-time RT–PCR methods, genotyping RT-LAMP method and LAMP plus peptide nucleic acid (PNA) probe detection methods have been developed to correctly identified SARS-CoV-2 variants, which is also why LAMP technology has attracted much attention. LAMP detection technology combined with lateral flow assay, microfluidic technology and other sensing technologies can effectively enhance signals by nucleic acid amplification and help to give the resulting output in a faster, more convenient and user-friendly way. At present, LAMP plays an important role in the detection of SARS-CoV-2.
Sedimentary evolution of lagoons along the Namibian coast reveals fluctuation in Holocene biogeographic faunal provinces, upwelling intensity and sea level
Authors: Schüller Irka , Belz Lukas , Wilkes Heinz , Wehrmann Achim
Published: December 2022

Within the wave-dominated and high-energy depositional environment of the hyper-arid Namibian coast, lagoons and related saltpans represent one of the few regional settings in which sediments originating from both marine and terrestrial sources can accumulate under sheltered conditions. This allows for an approximately continuous depositional record of mid to late Holocene coastal evolution. For this paleoenvironmental reconstruction, 26 sediment cores from six coastal (paleo-)lagoons were taken and investigated along a 430 km-long latitudinal gradient. Based on 56 age determinations of sediments and shell material, the initial formation of the studied lagoons can be dated back to 6.0–5.3 cal kyr BP. The sediment cores present different types of lithoclastic sediments which can be assigned to five sedimentary facies ranging from sand spit sediments rich in shell material to eolian dune sands and evaporites. From these cores, 221 samples of macrobenthic faunal material have been collected and determined to possess 46 shallow marine species. Biogeographic analyses have resulted in the identification of 10 (sub-)tropical warm water species that are not part of the regional benthic fauna in the present upwelling system. Age determinations of the shell material revealed four phases of biogeographic range expansion/shift into the study area, at 5.3 cal kyr BP, 2.8 cal kyr BP, 1.2–0.9 cal kyr BP, and 0.36–0.12 cal kyr BP from both the northern tropical Angola Current as well as from the southern subtropical Agulhas Current. The combination of datasets from this study with published datasets of regional sea-level fluctuations and upwelling intensities presents an apparent correlation between both processes and presumably an additional linkage to the ENSO and Benguela Niño variability.
Engaging practitioners as co-researchers in national policy evaluations as resistance to patriarchal constructions of expertise: The case of the end of year three evaluation of the access and inclusion model
Authors: Sheridan Denise , Robinson Deborah , Codina Geraldene , Gowers Sofia J. , O’Sullivan Lisha , Ring Emer
Published: December 2022

Seventeen Practitioner Researchers (PRs) were engaged as co-researchers in an evaluation commissioned by Ireland’s Department of Childhood, Equality, Disability, Integration, and Youth (DCEDIY), as an innovative aspect in methodological design. The evaluation investigated the implementation and impact of Ireland’s award winning policy for the inclusion of children with disabilities in mainstream pre-schools, the Access and Inclusion Model (AIM). As co-researchers in the project, the PRs constructed case studies of pre-schools, and children who were being supported by AIM. In this context, this paper draws on feminist theory to present the rationale for involving PRs as co-researchers in evaluations of high profile national programs like AIM. It also applies thematic analysis to a critical reflection written by one co-researcher (who is also the lead author), in which she writes about her gendered experience of being a PR. Thematic Analysis (TA) is applied to this critical reflection to explore the way in which the PR role may have impacted on her professional identity and agency. Three themes were constructed from the TA which included expertise as a resource for advocacy, personal and professional development, and continual learning and inclusive practice. The findings were interpreted through a feminist lens, and cast light on the way that the PR frames professional potency within more feminine constructions of power related to care, nurture, collaboration, nurturing and enabling. They also demonstrate how, in this particular case, the PR role had a transformative impact on expert identity, and enriched capitals for empowering others. The paper ends with a call for more participative approaches to the evaluation of national policies through the engagement of practitioners as researchers. It is argued that this would result in evaluations that were more attuned to the vernacular of practice, and hence more impactful. It also offers opportunities for professional development whilst symbolizing the validation of practitioner expertise by policy makers in a feminized sector where, low pay and low status have long been issues of concern.
Gasless endoscopic thyroidectomy via modified areola approach with a simple flap-lifting technique
Authors: Guo Tao , Wu Zehui , He Juntong , Liu Defeng , Wan Hong , Li Yangyang , Peng Shihao , Xu Aman
Published: December 2022

Objective

Studies have shown that carbon dioxide (CO2) insufflation during endoscopic thyroidectomy is associated with many risks. Recently, we have designed a simple lifting tool using Kirschner wire. We aimed to use this tool for flap-lifting in modified areola approach endoscopic thyroidectomy and compare it with conventional CO2 insufflation.

Methods

In a prospective study, patients who underwent endoscopic thyroidectomy via modified areola approach were randomly assigned into gasless (n = 20) or CO2 groups (n = 22). Pre-operative variables included age, gender, tumor diameter, and clinical diagnosis. Intra-operative hemodynamic monitoring included mean arterial pressure, heart rate, pulse oximetry, end-tidal carbon dioxide (ET-CO2) and arterial pH. Other intra-operative details included total operative time, operative blood loss, conversion from endoscopic surgery to open surgery, intra-operative events, and endoscope video score. Postoperatively, the hospital stay, drainage volume, and complications were recoded.

Results

Patient characteristics were not different between the two groups. During the operation, ET-CO2 levels were significantly higher in the CO2 group (P < 0.05), whereas arterial pH levels were significantly lower (P < 0.05). The CO2 group had longer operation time and higher endoscope clarity VAS score than gasless group. Hospital stay, drainage volume, and postoperative complications did not differ significantly between the two groups (P > 0.05).

Conclusions

The gasless endoscopic thyroidectomy we performed via our Kirschner wire hook was safe, feasible, and yielded good results.
Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study
Authors: Simon Virginie , Robin Geoffroy , Keller Laura , Ternynck Camille , Jonard Sophie , Robin Camille , Decanter Christine , Plouvier Pauline
Published: December 2022

Objective

The need of luteal support after FET is no longer to be proven. Different routes of progesterone administration are available with interindividual differences in metabolization and serum progesterone levels, the latter being highly correlated with pregnancy and delivery rates. The administration of 2 different routes of progestogen significantly improves success rates in FET. The aim of the current study was to investigate the added value to combine intramuscular administration of progesterone to dydrogesterone in fresh embryo transfer.

Methods

This is a retrospective study from prospectively collected data. Patient, aged between 18 and 43 years old, had received a fresh blastocyst transfer between January 2021 and June 2021. In the first group, all patients received only oral dydrogesterone 10mg, three times a day, beginning the evening of oocyte retrieval. In the second group, patients received, in addition to dydrogesterone, a weekly intramuscular injection of progesterone started the day of embryo transfer. Primary endpoint was ongoing pregnancy rate.

Results

171 fresh single blastocyst transfers have been performed during this period. 82 patients were included in “dydrogesterone only” and 89 patients in “dydrogesterone + IM”. Our two groups were comparable except for body mass index. After adjustment on BMI, our two groups were comparable regarding implantation rate, early pregnancy rate (46.1 versus 54.9, OR 1.44 [0.78; 2.67], p=0.25) miscarriage rate, ongoing pregnancy rate (30.3 versus 43.9, OR 1.85 [0.97; 3.53] p= 0.06).

Conclusion

Using systematically long acting intramuscular progesterone injection in addition to oral dydrogesterone as luteal phase support seems to have no significant impact on IVF outcomes when a single fresh blastocyst transfer is performed.
Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism
Authors: d’Alva Catarina Brasil , Barreto André Rodrigues Façanha , Nogueira-Barbosa Marcello H. , Arruda Caio César Cavalcante , Albuquerque Áurea Maíla , Praciano Débora Mota Cordeiro , Viana Rodrigo Ponte , Gadelha Daniel Duarte , Viana Jr Antônio Brazil , Moreira Ilana Marques , Moura Filho Francisco José Rodrigues de , Junqueira Ana Flávia Torquato de Araújo , Montenegro Jr Renan Magalhães
Published: December 2022

Introduction

Hypoparathyroidism (HP) is a rare endocrine disease and there are little data available on the risk of fragility fractures in these patients. PTH deficiency results in a positive bone balance with higher bone mass in all skeletal sites. However, whether these structural and dynamic skeletal changes have a negative impact on the fracture risk, it is not known.

Methods

Aiming to investigate the risk of insufficiency vertebral fractures in HP, defined using morphometric criteria, a consecutive sampling of 44 women with chronic postsurgical HP was compared to a control group of 44 adult healthy women, matched by age with patients. Vertebral fractures were analyzed by the semiquantitative Genant’s method followed by quantitative vertebral morphometry.

Results

Morphometric vertebral fractures were identified in 5/44 (11.4%) patients and in 3/44 (6.8%) controls (p=0.731). Most fractures were classified as Genant II and III grades in HP patients, whereas most were Genant I in controls. A logistic regression multivariate analysis was conducted in which age, BMI and parathyroid status were the independent variables, and morphometric vertebral fracture was the dependent variable, but none of these factors was a significant predictor of fracture in this population (OR 1.01, 95% CI 0.96-1.07, p=0.634 for age; OR 2.24, 95%CI 0.47-10.50, p=0.306 for the presence/absence of HP and OR 0.92, 95% CI 0.76-1.10, p=0.369 for BMI).

Conclusion

The results of this study cannot ensure a higher risk of fragility vertebral fractures in postsurgical HP patients. Instead, we only observed higher Genant grade classification of the deformed vertebrae in our sample.
DE optimized IPIDF controller for management frequency in a networked power system with SMES and HVDC link
Authors: Biswal Ashutosh , Dwivedi Prakash , Bose Sourav
Published: December 2022

A major concern is frequency change with load. So, Load Frequency Control (LFC) of an interconnected power system is proposed in this research using a unique integral plus proportional integral derivative controller with filter (IPIDF). The Differential Evolution (DE) algorithm is used to optimize the integral plus proportional integral derivative controller with filter controller parameters for a two-area power system. By contrasting the results of the proposed method with those of recently published optimization techniques for the same power system, such as the Particle Swarm Optimization (PSO), Genetic Algorithm (GA), Firefly Algorithm (FA), and Differential Evolution (DE) based Proportional integral derivative (PID) and PIDF controllers, the superiority of the integral plus proportional integral derivative controller with filter approach is made clear. It is possible to determine the system performance index like integral time multiplied the absolute error (ITAE) and the settling time (Ts). The power system with superconducting magnetic energy storage and an HVDC link is also included in the proposed work, and the values of the suggested integral plus proportional integral derivative controller with filter controllers are evaluated using the Differential Evolution method. By comparing the outcomes with the Differential Evolution tuned PIDF controller for the identical power systems, the suggested controller’s superiority is demonstrated. To show the stability of the recommended Differential Evolution algorithm tuned integral plus proportional integral derivative controller with filter controller, the speed governor, turbine, synchronizing coefficient, and frequency bias parameters’ time constants and operating load conditions are varied in the range of +25 to −25% from their nominal values, along with the magnitude and location of step load perturbation and pulse load perturbation, to perform sensitivity analysis. According to research, proposed integral plus proportional integral derivative controller with filter controllers offer greater dynamic response by minimizing time required to settle and undershoots than Proportional integral derivative controllers and PIDF controllers. MATLAB/Simulink is used to run the simulations.
Mapping evidence on postpartum modern family planning service uptake among women in Ethiopia: A scoping review
Authors: Cherie Niguss , Abera Mulumebet , Tura Gurmesa
Published: December 2022

Background

In Ethiopia, different fragmented studies have been conducted to assess the determinants and uptake of postpartum modern family planning services. There is discrepancy and inconsistency among reported studies on postpartum modern family planning service uptake. The scoping review aimed to collect evidence on postnatal birth control service use and supply a chance to spot key ideas and gaps to research, policy revision, and changes in strategies.

Methods

There were different process steps in this scoping review which included analysis questions, distinctive relevant studies, study choice, charting the information, and eventually collating, summarizing, and reporting the results. A search was conducted through scientific databases like PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Hinari, and Google Scholar. The first outcome of this scoping review was postpartum family planning service uptake after childbirth in Ethiopia. The Preferable Reporting Information in Systematic Review and Meta-Analysis (PRISMA) flow diagram was used to select and summarize the selection procedure of the articles. The information of the chosen studies was sorted using the subsequent categories: authors, year of publication, study location, main study objective, and method employed for information analyses.

Results

A total of 1,607 records were reclaimed from the database searches and reference list review. A total of 596 articles were identified in PubMed, 375 in CINAHL, 576 in Hinari, and 60 records in Google Scholar. A total of 1,607 literature studies were checked for replication, and 840 records were excluded. The bulk of articles (n = 420) were excluded because they did not focus on postpartum family planning service, and 322 articles were excluded due to study setting discrepancy. The remaining 28 full-text articles were read in full using the preidentified inclusion criteria and included in the scoping review for analysis.

Conclusion

Generally, this scoping review identified different fragmented and inconsistent research findings on the uptake of postpartum modern family planning in Ethiopia. Almost all studies were observational studies that lack interventional study designs to provide evidence-based interventions to improve postpartum family planning uptake. There is a definite need for further interventional and qualitative research to improve early postpartum family planning service uptake that improves maternal and child health.
Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: A narrative review
Authors: Mei Wei-Jian , Mi Mi , Qian Jing , Xiao Nan , Yuan Ying , Ding Pei-Rong
Published: December 2022

Colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch repair (dMMR) show molecular and clinicopathological characteristics that differ from those of proficient mismatch repair/microsatellite stable CRCs. Despite the importance of MSI-H/dMMR status in clinical decision making, the testing rates for MSI and MMR in clinical practice remain low, even in high-risk populations. Additionally, the real-world prevalence of MSI-H/dMMR CRC may be lower than that reported in the literature. Insufficient MSI and MMR testing fails to identify patients with MSI-H/dMMR CRC, who could benefit from immunotherapy. In this article, we describe the current knowledge of the clinicopathological features, molecular landscape, and radiomic characteristics of MSI-H/dMMR CRCs. A better understanding of the importance of MMR/MSI status in the clinical characteristics and prognosis of CRC may help increase the rates of MMR/MSI testing and guide the development of more effective therapies based on the unique features of these tumors.
High-intensity chemotherapy improved the prognosis of patients with high-grade B-cell lymphoma
Authors: Chen Yanfang , Cai Qing , Chang Yu , Zhang Mingzhi , Li Zhaoming
Published: December 2022

Objective

High-grade B-cell lymphoma (HGBL) is highly aggressive and has a poor prognosis.

Methods

The clinical data of 76 patients with High-grade B-cell lymphoma treated in our lymphoma center from July 2016 to April 2020 were analyzed retrospectively. The clinical features, treatment and prognosis of patients with two types of high-grade B-cell lymphoma were compared and analyzed.

Results

Among 76 patients with high-grade B-cell lymphoma, 44 cases (57.9%) were high-grade B-cell lymphoma, accompanied by MYC and Bcl-2 and/or Bcl-6 rearrangement (HGBLR) patients, and 32 cases (42.1%) were HGBL, NOS patients. The bone marrow infiltration, IPI (international prognostic index), Ann Arbor stage (III/IV), extranodal disease are more likely to occur in HGBLR group (P <0.05). Survival analysis of patients showed that overall survival (OS) and progression free survival (PFS) in HGBLR group were significantly shorter than those in HGBL, NOS group (median OS: 21 months vs not reached, P=0. 022; median PFS: 5 months vs 12 months, P = 0. 001). Further analysis demonstrated that, as compared with R-CHOP regimen, patients with HGBL who received high-intensity chemotherapy regimens (DA-EPOCH-R, R-CODOX-M/IVAC and R-Hyper-CVAD) had longer OS (median OS, 16 months vs not reached, P=0. 007) and PFS (median PFS, 5 months vs 11 months, P<0.001). Moreover, mu1tivariate ana1ysis showed that high-intensity chemotherapy regimens were independent risk factors for both PFS (P =0.001, HR: 0.306, 95% CI: 0.153–0.610) and OS (P =0.004, HR: 0.262, 95% CI: 0.105–0.656) in patients with HGBL.

Conclusions

HGBLR patients have worse prognosis than patients with HGBL, NOS. High-intensity chemotherapy may improve the prognosis of patients with HGBL.
Clinical cure rate of inactive HBsAg carriers with HBsAg <200 IU/ml treated with pegylated interferon
Authors: Li Hong , Liang Shan , Liu Lili , Zhou Daqiong , Liu Yali , Zhang Yang , Chen Xinyue , Zhang Jing , Cao Zhenhuan
Published: December 2022

Purpose

HBsAg clearance represents clinical cure for patients with hepatitis B, but remains difficult to obtain for most HBV-infected patients. Recent studies have shown that inactive HBsAg carriers treated with pegylated interferon can achieve higher clinical cure rates, which may imply that the lower the baseline HBsAg quantification, the higher HBsAg clearance rate. Therefore, this study further investigated the HBsAg clearance rate in inactive HBsAg carriers with low level of HBsAg (<200 IU/ml) treated with pegylated interferon.

Methods

This is a prospective cohort study. Inactive HBsAg carriers with HBsAg<200 IU/ml were divided into treatment and control groups. Pegylated interferon was administered to the patients in therapeutic group for 96 weeks. The patients in control group underwent 96 weeks of observation without any anti-viral treatment. All patients were tested for HBsAg, anti-HBs, HBV DNA, liver function, blood count, thyroid function, thyroid antibodies and autoantibodies at baseline, week 12, 24, 36, 48, 60, 72, 84 and 96. Controlled attenuation parameter (CAP) and liver stiffness measure (LSM) were evaluated at baseline and week 96. Patients were classified into no steatosis, mild steatosis, moderate steatosis and severe steatosis according to the value of CAP.

Results

A total of 174 inactive HBsAg carriers with HBsAg<200IU/ml were enrolled, including 84 in the treatment group and 90 in the control group. In the treatment group, HBsAg clearance rate was 30.77% (24/78) at week 48, and increased to 57.69% (45/78) at week 96. HBsAg clearance occurred in 2 patients with a clearance rate of 2.27% (2/88) in control group, The HBsAg clearance rate of the treatment group was significantly higher than that of the control group (P<0.001). HBsAg clearance was significantly higher in patients with moderate steatosis than in those without steatosis (74.07% vs. 48.15%, p=0.008) at week 96.

Conclusion

High HBsAg clearance rate could be obtained for inactive HBsAg carriers with HBsAg< 200 IU/ml treated with peginterferons. Inactive HBsAg carriers with moderate hepatic steatosis are more sensitive for the treatment.
Effect of dietary soybean saponin Bb on the growth performance, intestinal nutrient absorption, morphology, microbiota, and immune response in juvenile Chinese soft-shelled turtle (Pelodiscus sinensis)
Authors: Wang Yue , Jia Xinyue , Guo Zixue , Li Ling , Liu Tianyu , Zhang Peiyu , Liu Haiyan
Published: December 2022

Soybean meal is widely applied in the aquafeeds due to the limitation of fish meal resources. Numerous studies have manifested that dietary soybean saponin, an anti-nutrient factor in soybean meal, may slow growth and induce intestinal inflammation in aquatic animals, but the possible causes are unclear. The juvenile Pelodiscus sinensis (mean initial body weight: 6.92 ± 0.03 g) were fed basal diet (CON group) and 2.46% soybean saponin Bb-supplemented diet (SAP group) for 35 days to further explore the effects of dietary soybean saponin Bb on the growth performance, apparent digestibility coefficients, intestinal morphology, the gut microbiota, intestinal transporters/channels, and immune-related gene expression. The results indicated that dietary soybean saponin Bb significantly decreased final body weight, specific growth rate, protein deposition ratio, and apparent digestibility coefficients (dry matter, crude protein, and crude lipid) of nutrients in Pelodiscus sinensis, which may be closely correlated with markedly atrophic villus height and increased lamina propria width in the small intestine. In addition, plasma contents of cholesterol, calcium, phosphorus, potassium, lysozyme, and C3 were significantly decreased in the SAP group compared with the control group. Soybean saponin Bb significantly downregulated the mRNA levels of glucose transporter 2, fatty acid binding protein 1 and fatty acid binding protein 2, amino acid transporter 2, b0,+-type amino acid transporter 1, and sodium-dependent phosphate transport protein 2b in the small intestine. At the same time, the expressions of key transcription factors (STAT1, TBX21, FOS), chemokines (CCL3), cytokines (TNF-α, IL-8), and aquaporins (AQP3, AQP6) in the inflammatory response were increased by soybean saponin Bb in the large intestine of a turtle. Additionally, dietary supplementation of SAP significantly reduced the generic abundance of beneficial bacteria (Lactobacillus, Bifidobacterium, and Bacillus) and harmful bacteria (Helicobacter and Bacteroides). In a nutshell, dietary supplementation of 2.46% soybean saponin not only hindered the growth performance by negatively affecting the macronutrients absorption in the small intestine but also induced an inflammatory response in the large intestine possibly by damaging the intestinal morphology, disturbing the intestinal microbiota and decreasing intestinal epithelial cell membrane permeability.