bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Technology Acceptance Behavior of Romanian Preschool Teachers
Authors: Rad Dana , Egerău Anca , Roman Alina , Dughi Tiberiu , Kelemen Gabriela , Balaș Evelina , Redeș Adela , Schipor Maria-Doina , Clipa Otilia , Mâță Liliana , Maier Roxana , Rad Gavril , Runcan Remus , Kiss Csaba
Published: February 2023

This study investigates how compatibility and perceived enjoyment affect the link between intention to use and actual technology use in Romanian preschool education, building on earlier studies. Methods: 300 participants were invited to participate in this research from 15 Romanian counties. 182 preschool teachers’ questionnaires were utilized for data analysis after the return and screening of responses. A valid and accurate scale evaluating preschool teachers’ behavior towards technology adoption was included in the questionnaire, along with self-reported demographic data, professional identification, and other information. Data was analyzed using SPSS V.16. Results: (1) Intention to use, compatibility, perceived enjoyment, and actual use were positively associated. (2) The effect of compatibility and perceived enjoyment on the link between intention to use and actual technology use was carried out in the following way: Intention to use → Compatibility with technology → Perceived enjoyment → Actual use. We hypothesize that intention to use affects compatibility, compatibility affects perceived enjoyment, and, lastly, perceived enjoyment affects actual use. For a more robust validation of results, we have also modelled this relationship with the Radial Basis Function (RBF) neural network. Conclusion: Compatibility and perceived enjoyment partially mediate the relationship between intention to use and actual technology use in class by Romanian preschool teachers. According to the theory of planned behavior, this study brought to light the intricacy of the relationship between preschool teachers’ intention to utilize technology in the classroom and their actual usage of it. Limitations and implications are discussed.
A Study on Chinese Audience’s Receptive Behavior towards Chinese and Western Cultural Hybridity Films Based on Grounded Theory—Taking Disney’s Animated Film Turning Red as an Example
Authors: Chen Rui , Liu Yi
Published: February 2023

For a long time, Chinese audiences have not had a high opinion of hybrid Chinese and Western movies. However, the unanimous praise for Turning Red in China se ems to have reversed this situation. In order to verify whether the attitudinal behavior of Chinese audiences toward the film’s hybridization of Chinese and Western cultures has changed, this study collected textual materials reflecting the Chinese audience’s receptive attitudes toward the film: Douban reviews, short reviews, questionnaires and Mtime.com reviews. Through a grounded study of 664,312 words, a total of 16 initial categories and four main categories were obtained. Finally, a cognitive–emotional–attitudinal mechanism model was formed to explain the audience’s receptive behavior process. The study found that Chinese audiences’ positive reception of Turning Red comes more from the fact that the film touches on personal emotions and focuses on a series of issues such as growing up, family, and gender, with intergenerational conflict as the core. The audience achieves self-projection and empathy while watching the film, rather than recognizing the Chinese culture presented therein. On this basis, the research further found that the internal structure of the current cultural hybridity has not changed greatly. The reason audiences do not give a high evaluation of cultural hybridity films lies in the lack of conscious distinction between the hybridity culture and the local culture. At the same time, in terms of cross-cultural creation, we should abandon the blind pursuit of cultural symbols, take root in cultural soil and then pay attention to more specific problems. This study reveals that the key factor affecting the audience’s receptive behavior toward cultural hybridity films is not necessarily the performance of local culture, which is of great significance for establishing new evaluation criteria.
Review of Parameters Measured to Characterize Classrooms’ Indoor Environmental Quality
Authors: Tran Minh Tien , Wei Wenjuan , Dassonville Claire , Martinsons Christophe , Ducruet Pascal , Mandin Corinne , Héquet Valérie , Wargocki Pawel
Published: February 2023

As attention to indoor environmental quality (IEQ) grows, a systematic strategy for assessing IEQ in schools needs to be developed. For this purpose, this paper presents a summary of parameters measured in school classrooms to characterize the quality of thermal, acoustic, and visual environments and indoor air quality (IAQ). The summary is based on a review of published literature reporting measurements in schools in Europe and North America in the past ten years. It also summarizes the measurement protocols and measured concentrations. Eighty-eight papers describing measurements in schools were identified and analyzed. No unique standardized measuring method was used in the reviewed studies and different parameters were measured. The most often measured parameters were those describing the thermal environment and IAQ. The former mainly comprised air temperature and relative humidity. The latter mainly comprised concentrations of carbon dioxide, particulate matter, radon, formaldehyde, and some volatile organic compounds. The measured parameters describing acoustic and visual environments mainly comprised noise level, reverberation time, and illuminance. A few studies reported additional measurements of radiant temperature, operative temperature, and speech intelligibility. Measurement protocols from different studies show inconsistency in sampling duration and location and expressed results. Measured concentrations also show high variation between studies, with some pollutants exceeding the threshold values proposed by local and/or international organizations such as the World Health Organization (WHO). This review provides the reference for developing a rating scheme and protocols for uniform characterization of classroom IEQ.
Mechanical Behaviors of a Buckling-Plate Self-Centering Friction Damper
Authors: Wang Qinting , Shen Hu , Zhang Zhenhua , Qian Hui
Published: February 2023

In order to improve the resilience of structures subjected to strong earthquakes, a buckling-plate self-centering friction damper (BPSCFD) with low post-yielding stiffness is proposed, which consists of a group of post-buckling plates and a self-centering variable friction mechanism. The damper is intended to not only reduce the peak and residual deformation of structures, but also to limit the additional internal force of the structural elements. Through theoretical derivation and finite element simulation, the hysteretic damping and self-centering characteristics of BPSCFDs are studied. In order to examine the seismic performance of the BPSCFDs, the dampers are employed to retrofit a double-columns bridge bent, and the corresponding elastic-plastic time history analysis is conducted. The results show that the force-displacement relationships of BPSCFDs with different parameter combinations are characterized by typical flag-shaped self-centering hysteretic loops and low post-yielding stiffness, and the dampers can effectively reduce the peak and residual deformation of the bridge bent without increasing the peak acceleration and base shear. The research results could supply a guideline for the design and application of the damper.
Antigene MYCN Silencing by BGA002 Inhibits SCLC Progression Blocking mTOR Pathway and Overcomes Multidrug Resistance
Authors: Bortolotti Sonia , Angelucci Silvia , Montemurro Luca , Bartolucci Damiano , Raieli Salvatore , Lampis Silvia , Amadesi Camilla , Scardovi Annalisa , Nieddu Giammario , Cerisoli Lucia , Paganelli Francesca , Chiarini Francesca , Teti Gabriella , Falconi Mirella , Pession Andrea , Hrelia Patrizia , Tonelli Roberto
Published: February 2023

Small-cell lung cancer (SCLC) is the most aggressive lung cancer type, and is associated with smoking, low survival rate due to high vascularization, metastasis and drug resistance. Alterations in MYC family members are biomarkers of poor prognosis for a large number of SCLC. In particular, MYCN alterations define SCLC cases with immunotherapy failure. MYCN has a highly restricted pattern of expression in normal cells and is an ideal target for cancer therapy but is undruggable by traditional approaches. We propose an innovative approach to MYCN inhibition by an MYCN-specific antigene—PNA oligonucleotide (BGA002)—as a new precision medicine for MYCN-related SCLC. We found that BGA002 profoundly and specifically inhibited MYCN expression in SCLC cells, leading to cell-growth inhibition and apoptosis, while also overcoming multidrug resistance. These effects are driven by mTOR pathway block in concomitance with autophagy reactivation, thus avoiding the side effects of targeting mTOR in healthy cells. Moreover, we identified an MYCN-related SCLC gene signature comprehending CNTFR, DLX5 and TNFAIP3, that was reverted by BGA002. Finally, systemic treatment with BGA002 significantly increased survival in MYCN-amplified SCLC mouse models, including in a multidrug-resistant model in which tumor vascularization was also eliminated. These findings warrant the clinical testing of BGA002 in MYCN-related SCLC.
Survival in Colon, Rectal and Small Intestinal Cancers in the Nordic Countries through a Half Century
Authors: Tichanek Filip , Försti Asta , Liska Vaclav , Hemminki Akseli , Hemminki Kari
Published: February 2023

Background: Survival studies in intestinal cancers have generally shown favorable development, but few studies have been able to pinpoint the timing of the changes in survival over an extended period. Here, we compared the relative survival rates for colon, rectal and small intestinal cancers from Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE). Design: Relative 1-, 5- and 5/1-year conditional survival data were obtained from the NORDCAN database for the years 1971–2020. Results: The 50-year survival patterns were country-specific. For colon and rectal cancers, the slopes of survival curves bended upwards for DK, were almost linear for NO and bended downwards for FI and SE; 5-year survival was the highest in DK. Survival in small intestinal cancer was initially below colon and rectal cancers but in FI and NO it caught up toward the end of the follow-up. Conclusions: Relative survival in intestinal cancers has developed well in the Nordic countries, and DK is an example of a country which in 20 years was able to achieve excellent survival rates in colon and rectal cancers. In the other countries, the increase in survival curves for colon and rectal cancer has slowed down, which may be a challenge posed by metastatic cancers.
Three Months’ PSA and Toxicity from a Prospective Trial Investigating STereotactic sAlvage Radiotherapy for Macroscopic Prostate Bed Recurrence after Prostatectomy—STARR (NCT05455736)
Authors: Francolini Giulio , Garlatti Pietro , Di Cataldo Vanessa , Detti Beatrice , Loi Mauro , Greto Daniela , Simontacchi Gabriele , Morelli Ilaria , Burchini Luca , Allegra Andrea Gaetano , Frosini Giulio , Ganovelli Michele , Salvestrini Viola , Olmetto Emanuela , Visani Luca , Becherini Carlotta , Valzano Marianna , Carnevale Maria Grazia , Roghi Manuele , Serni Sergio , Mattioli Chiara , Desideri Isacco , Livi Lorenzo
Published: February 2023

Biochemical recurrences after radical prostatectomy (RP) can be managed with curative purpose through salvage radiation therapy (SRT). RT dose escalation, such as stereotactic RT (SSRT), may improve relapse-free survival in this setting. STARR trial (NCT05455736) is a prospective multicenter study including patients affected by macroscopic recurrence within the prostate bed after RP treated with SSRT. Recurrence was detected with a Choline or PSMA CT-PET. In the current analysis, the early biochemical response (BR) rate and toxicity profile after three months of follow-up were assessed. Twenty-five patients were enrolled, and data about BR and toxicity at three months after treatment were available for 19 cases. Overall, BR was detected after three months in 58% of cases. Four G1–G2 adverse events were recorded; no G ≥ 3 adverse events were detected. SSRT appears feasible and safe, with more than half of patients experiencing BR and an encouraging toxicity profile. The STARR trial is one of the few prospective studies aimed at implementing this promising treatment strategy in this scenario.
Real-World Data Validation of NAPOLI-1 Nomogram for the Prediction of Overall Survival in Metastatic Pancreatic Cancer
Authors: Su Yung-Yeh , Chiang Nai-Jung , Yang Yi-Hsin , Yen Chia-Jui , Bai Li-Yuan , Chiu Chang-Fang , Chuang Shih-Chang , Yang Shih-Hung , Chou Wen-Chi , Chen Jen-Shi , Chiu Tai-Jan , Chen Yen-Yang , Chan De-Chuan , Peng Cheng-Ming , Chiu Sz-Chi , Li Chung-Pin , Shan Yan-Shen , Chen Li-Tzong
Published: February 2023

Background: The nomogram derived from the pivotal phase III NAPOLI-1 study demonstrated a significant ability to predict median overall survival (OS) in gemcitabine-refractory metastatic pancreatic ductal adenocarcinoma (PDAC) treated with liposomal irinotecan plus fluorouracil and leucovorin (nal-IRI+5-FU/LV). However, the NAPOLI-1 nomogram has not been validated in a real-world setting and therefore the applicability of the NAPOLI-1 nomogram in daily practice remains unknown. This study aims to evaluate the NAPOLI-1 nomogram in a multicenter real-world cohort. Methods: The NAPOLI-1 nomogram was applied to a previously established cohort of metastatic PDAC patients treated with nal-IRI+5-FU/LV in nine participating centers in Taiwan. Patients were divided into three risk groups according to the NAPOLI-1 nomogram. The survival impact of relative dose intensity at 6 weeks (RDI at 6 weeks) in different risk groups was also investigated. Results: Of the 473 included patients, the median OSs of patients classified as low (n = 156), medium (n = 186), and high (n = 131) risk were 10.9, 6.3, and 4.3 months, respectively (p < 0.0001). The survival impact of RDI at 6 weeks remained significant after stratification by risk groups, adjustment with Cox regression, inverse probability weighting, or propensity score matching. Conclusions: Our results support the usefulness of the NAPOLI-1 nomogram for risk stratification in gemcitabine-refractory metastatic PDAC treated with nal-IRI+5-FU/LV in daily practice. We further showed that the RDI at 6 weeks is an independent prognostic factor beyond the NAPOLI-1 nomogram.
One-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns
Authors: Metayer Catherine , Imani Partow , Dudoit Sandrine , Morimoto Libby , Ma Xiaomei , Wiemels Joseph L. , Petrick Lauren M.
Published: February 2023

Leukemia is the most common cancer in children in industrialized countries, and its initiation often occurs prenatally. Folic acid is a key vitamin in the production and modification of DNA, and prenatal folic acid intake is known to reduce the risk of childhood leukemia. We characterized the one-carbon (folate) metabolism nutrients that may influence risk of childhood acute lymphoblastic leukemia (ALL) among 122 cases diagnosed at age 0–14 years during 1988–2011 and 122 controls matched on sex, age, and race/ethnicity. Using hydrophilic interaction chromatography (HILIC) applied to neonatal dried blood spots, we evaluated 11 folate pathway metabolites, overall and by sex, race/ethnicity, and age at diagnosis. To conduct the prediction analyses, the 244 samples were separated into learning (75%) and test (25%) sets, maintaining the matched pairings. The learning set was used to train classification methods which were evaluated on the test set. High classification error rates indicate that the folate pathway metabolites measured have little predictive capacity for pediatric ALL. In conclusion, the one-carbon metabolism nutrients measured at birth were unable to predict subsequent leukemia in children. These negative findings are reflective of the last weeks of pregnancy and our study does not address the impact of these nutrients at the time of conception or during the first trimester of pregnancy that are critical for the embryo’s DNA methylation programming.
Cancer Treatment Patterns and Factors Affecting Receipt of Treatment in Older Adults: Results from the ASPREE Cancer Treatment Substudy (ACTS)
Authors: Muhandiramge Jaidyn , Warner Erica T. , Zalcberg John R. , Haydon Andrew , Polekhina Galina , van Londen Gijsberta J. , Gibbs Peter , Bernstein Wendy B. , Tie Jeanne , Millar Jeremy L. , Mar Victoria J. , McNeil John J. , Woods Robyn L. , Orchard Suzanne G.
Published: February 2023

Introduction: Cancer treatment planning in older adults is complex and requires careful balancing of survival, quality of life benefits, and risk of treatment-related morbidity and toxicity. As a result, treatment selection in this cohort tends to differ from that for younger patients. However, there are very few studies describing cancer treatment patterns in older cohorts. Methods: We used data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial and the ASPREE Cancer Treatment Substudy (ACTS) to describe cancer treatment patterns in older adults. We used a multivariate logistic regression model to identify factors affecting receipt of treatment. Results: Of 1893 eligible Australian and United States (US) participants with incident cancer, 1569 (81%) received some form of cancer treatment. Non-metastatic breast cancers most frequently received treatment (98%), while haematological malignancy received the lowest rates of treatment (60%). Factors associated with not receiving treatment were older age (OR 0.94, 95% CI 0.91–0.96), residence in the US (OR 0.34, 95% CI 0.22–0.54), smoking (OR 0.57, 95% CI 0.40–0.81), and diabetes (OR 0.56, 95% CI 0.39–0.80). After adjustment for treatment patterns in sex-specific cancers, sex did not impact receipt of treatment. Conclusions: This study is one of the first describing cancer treatment patterns and factors affecting receipt of treatment across common cancer types in older adults. We found that most older adults with cancer received some form of cancer treatment, typically surgery or systemic therapy, although this varied by factors such as cancer type, age, sex, and country of residence.
Ten Considerations for Integrating Patient-Reported Outcomes into Clinical Care for Childhood Cancer Survivors
Authors: Horan Madeline R. , Sim Jin-ah , Krull Kevin R. , Ness Kirsten K. , Yasui Yutaka , Robison Leslie L. , Hudson Melissa M. , Baker Justin N. , Huang I-Chan
Published: February 2023

Patient-reported outcome measures (PROMs) are subjective assessments of health status or health-related quality of life. In childhood cancer survivors, PROMs can be used to evaluate the adverse effects of cancer treatment and guide cancer survivorship care. However, there are barriers to integrating PROMs into clinical practice, such as constraints in clinical validity, meaningful interpretation, and technology-enabled administration of the measures. This article discusses these barriers and proposes 10 important considerations for appropriate PROM integration into clinical care for choosing the right measure (considering the purpose of using a PROM, health profile vs. health preference approaches, measurement properties), ensuring survivors complete the PROMs (data collection method, data collection frequency, survivor capacity, self- vs. proxy reports), interpreting the results (scoring methods, clinical meaning and interpretability), and selecting a strategy for clinical response (integration into the clinical workflow). An example framework for integrating novel patient-reported outcome (PRO) data collection into the clinical workflow for childhood cancer survivorship care is also discussed. As we continuously improve the clinical validity of PROMs and address implementation barriers, routine PRO assessment and monitoring in pediatric cancer survivorship offer opportunities to facilitate clinical decision making and improve the quality of survivorship care.
Enhancing the Photocatalytic Activity of TiO2 for the Degradation of Congo Red Dye by Adjusting the Ultrasonication Regime Applied in Its Synthesis Procedure
Authors: Turcu Elvira , Coromelci Cristina Giorgiana , Harabagiu Valeria , Ignat Maria
Published: February 2023

Recently, the ultrasound-assisted sol-gel synthesis procedure of mesoporous titania (TiO2) photocatalysts caught the researcher’s attention, due to the physicochemical properties enhancement of the resulting titania nanomaterials. Thus, by varying different synthesis parameters particular characteristics could be obtained. In the present study, the ultrasound pulse on/off ratio has been considered and the effect of the envisaged parameter on the textural, morphological, and optical features of titania nanomaterial has been investigated. Therefore, X-ray Diffraction (XRD), Fourier-Transform Infrared spectroscopy (FTIR), N2-sorption measurements, SEM imaging, and UV-Vis Diffuse Reflectance spectroscopy (UVDR) have been used. And further, the photocatalytic activity of the prepared TiO2 materials was evaluated by the features developed about the applied ultrasound pulse on/off ratio as 1/1, 2/1, 3/1, 4/1, 1/3 and 2/2. It was found that the ultrasound pulse on/off ratio considered in the synthesis procedure of titania leads to TiO2 materials with different textural (SBET = 98–156 m2/g), morphological, and optical (Eg = 3.1–3.2 eV) characteristics. For this reason, TiO2 nanomaterials prepared were found to exhibit suitable features for photocatalytic applications. Thus, the TiO2 4.1 sample prepared at 4/1 ultrasound pulse on/off ratio revealed the highest photodegradation efficiency of Congo Red dye (98.28%) as the results of photocatalytic tests show. More than that, a possible reaction mechanism of the CR photodegradation process through the contribution of reactive oxygen species (·HO, ·O2−), holes (h+), and electrons (e−) of developed titania photocatalyst was proposed.
Synthesis of Hollow Mesoporous Silica Nanospheroids with O/W Emulsion and Al(III) Incorporation and Its Catalytic Activity for the Synthesis of 5-HMF from Carbohydrates
Authors: Ghosh Anirban , Chowdhury Biswajit , Bhaumik Asim
Published: February 2023

Controlling the particle size as well as porosity and shape of silica nanoparticles is always a big challenge while tuning their properties. Here, we designed a cost-effective, novel, green synthetic method for the preparation of perforated hollow mesoporous silica nanoparticles (PHMS-1) using a very minute amount of cationic surfactant in o/w-type (castor oil in water) emulsion at room temperature. The grafting of Al(III) through post-synthetic modification onto this silica framework (PHMS-2, Si/Al ~20 atomic percentage) makes this a very efficient solid acid catalyst for the conversion of monosaccharides to 5-HMF. Brunauer–Emmett–Teller (BET) surface area for the pure silica and Al-doped mesoporous silica nanoparticles (MSNs) were found to be 866 and 660 m2g−1, respectively. Powder XRD, BET and TEM images confirm the mesoporosity of these materials. Again, the perforated hollow morphology was investigated using scanning electron microscopic analysis. Al-doped hollow MSNs were tested for acid catalytic-biomass conversion reactions. Our results show that PHMS-2 has much higher catalytic efficiency than contemporary aluminosilicate frameworks (83.7% of 5-HMF yield in 25 min at 160 °C for fructose under microwave irradiation).
Effect of the Calcination Temperature of LaNiO3 on the Structural Properties and Reaction Performance of Catalysts in the Steam Reforming of Methane
Authors: Wang Yujie , Qian Shuairen , Chen Yuxin , Yan Binhang , Cheng Yi
Published: February 2023

The steam reforming of methane (SRM) reaction is a significant process for efficient syngas generation and for promising distributed hydrogen production. In this work, a series of LaNiO3 oxides were prepared using the Pechini method, calcined from 600 °C to 900 °C and tested for the SRM reaction. Fresh, reduced, and used samples were characterized using STA-MS-FTIR, in situ and ex situ XRD, N2 physical adsorption, H2-TPR, TEM, TPO, and Raman. The results show that LaNiO3 begins to crystallize at about 550 °C, and the increase in calcination temperature results in the following differences in the properties of the LaNiO3 samples: larger LaNiO3 grains, smaller specific surface area, higher reduction temperature, smaller Ni0 grains reduced from the bulk phase, and stronger metal–support interaction. The maximum CH4 conversion could be achieved over LaNiO3 calcinated at 800 °C. In addition, the effect of steam-to-carbon ratio (S/C) on the performance of the SRM reaction was studied, and a S/C of 1.5 was found to be optimal for CH4 conversion. Too strong a metal–support interaction and too much unreacted steam causes a loss of catalytic activity. Finally, it was also proved using TPO and Raman that an increase in calcination temperature improves the carbon deposition resistance of the catalyst.
Interplays of AMPK and TOR in Autophagy Regulation in Yeast
Authors: Alao John-Patrick , Legon Luc , Dabrowska Aleksandra , Tricolici Anne-Marie , Kumar Juhi , Rallis Charalampos
Published: February 2023

Cells survey their environment and need to balance growth and anabolism with stress programmes and catabolism towards maximum cellular bioenergetics economy and survival. Nutrient-responsive pathways, such as the mechanistic target of rapamycin (mTOR) interact and cross-talk, continuously, with stress-responsive hubs such as the AMP-activated protein kinase (AMPK) to regulate fundamental cellular processes such as transcription, protein translation, lipid and carbohydrate homeostasis. Especially in nutrient stresses or deprivations, cells tune their metabolism accordingly and, crucially, recycle materials through autophagy mechanisms. It has now become apparent that autophagy is pivotal in lifespan, health and cell survival as it is a gatekeeper of clearing damaged macromolecules and organelles and serving as quality assurance mechanism within cells. Autophagy is hard-wired with energy and nutrient levels as well as with damage-response, and yeasts have been instrumental in elucidating such connectivities. In this review, we briefly outline cross-talks and feedback loops that link growth and stress, mainly, in the fission yeast Schizosaccharomyces pombe, a favourite model in cell and molecular biology.
The Role of Macrophages in the Pathogenesis of Atherosclerosis
Authors: Blagov Alexander V. , Markin Alexander M. , Bogatyreva Anastasia I. , Tolstik Taisiya V. , Sukhorukov Vasily N. , Orekhov Alexander N.
Published: February 2023

A wide variety of cell populations, including both immune and endothelial cells, participate in the pathogenesis of atherosclerosis. Among these groups, macrophages deserve special attention because different populations of them can have completely different effects on atherogenesis and inflammation in atherosclerosis. In the current review, the significance of different phenotypes of macrophages in the progression or regression of atherosclerosis will be considered, including their ability to become the foam cells and the consequences of this event, as well as their ability to create a pro-inflammatory or anti-inflammatory medium at the site of atherosclerotic lesions as a result of cytokine production. In addition, several therapeutic strategies directed to the modulation of macrophage activity, which can serve as useful ideas for future drug developments, will be considered.
Injury Pathology in Young Gymnasts: A Retrospective Analysis
Authors: Williams Emma , Lloyd Rhodri , Moeskops Sylvia , Pedley Jason
Published: February 2023

Gymnastics has a history of high injury incidence rates. However, little is known about the injury pathology in young gymnasts. The purpose of this study was to fill gaps in the literature by providing insight into the injury pathology in gymnasts aged 6 to 17 years. This study was retrospective in design, where injury data were collected using a Qualtrics questionnaire and distributed via social media. The findings revealed that the most common injury site was the lower limb (60.5%), in particular, the ankle/foot (49%) and knee (27%). Overuse injuries and sprains were most prevalent among the lower limb (25% and 18.4%, respectively), and gymnasts seemed to have a tendency to train through injury with modifications to training. In conclusion, lower limb joint sprain and overuse injuries accounted for the majority of injuries in youth gymnasts. These injuries were more frequently reported in girls in the years associated with peak height velocity and beyond.
Clinical Examination Findings Can Accurately Diagnose Developmental Dysplasia of The Hip—A Large, Single-Center Cohort
Authors: Subaşı İzzet Özay , Veizi Enejd , Çepni Şahin , Alkan Hilmi , Oğuz Temel , Fırat Ahmet
Published: February 2023

Background: Physical examination findings such as limited hip abduction (LHA), asymmetric skin creases (ASC), and a popping sensation in the hip facilitate the diagnosis of developmental dysplasia of the hip (DDH). Screening with a simple physical examination during the first weeks of infancy is important for early detection of the condition, and a wide range of medical professionals, including general practitioners, obstetricians, pediatricians, and orthopedic surgeons etc. are involved in this process. The aim of this study was to determine the correlation between easily recognizable physical examination findings such as LHA, thigh/groin ACSs, and Ortolani and Barlow tests with ultrasound findings for the diagnosis of DDH. Methods: This study included 968 patients undergoing routine hip ultrasonography between December 2012 and January 2015. All patients were examined by an experienced orthopedic surgeon who was not the physician who performed the ultrasound examination to exclude bias between physical examination findings and ultrasound findings. Asymmetric skin folds (thigh and groin), limited abduction, Barlow and Ortolani tests were recorded. The relationship between the physical examination findings, ultrasound findings, and developmental dysplasia was investigated. Results: Of the 968 patients, 523 were female (54%) and 445 were male. On ultrasonography examination, 117 patients were found to have DDH. The sensitivity, specificity and negative predictive values of patients who were found to have both LHA and thigh/groin ASCs in all three physical examinations were high (83.8%, 70.2%, and 96.9%, respectively) while positive predictive values were found to be low (27.8%). Conclusion: Asymmetric skin creases on the thigh and groin and limited hip abduction, when evaluated together, have high sensitivity and specificity with additional high negative predictive values and could help during the initial screening process of DDH.
The Variable Influence of Orthotic Management on Hip and Pelvic Rotation in Children with Unilateral Neurogenic Equinus Deformity
Authors: Grisch Domenic , Stäuble Manuela , Baumgartner Sandra , van Hedel Hubertus J. A. , Meyer-Heim Andreas , Dreher Thomas , Krautwurst Britta
Published: February 2023

Background: Equinus deformity with or without concomitant drop foot is a common finding in children with unilateral spastic cerebral palsy and spastic hemiplegia of other causes. Hypothetically, these deformities may lead to pelvic retraction and hip internal rotation during gait. Orthoses are used to reduce pes equinus during gait and to restore hindfoot first contact. Objective: We aimed to investigate whether the use of orthotic equinus correction reduces rotational hip and pelvic asymmetries. Methods: In a retrospective study, 34 children with unilateral spastic cerebral palsy or spastic hemiplegia of other causes underwent standardized instrumented 3D gait analysis with and without orthotic equinus management. We analyzed the differences in the torsional profile during barefoot walking and while wearing orthoses, as well as investigated the influence of ankle dorsiflexion and femoral anteversion on pelvic and hip kinematics and hip kinetics. Results: Wearing orthoses corrected pes equinus and pelvic internal rotation at the end of the stance phase and in the swing phase compared to barefoot walking. Hip rotation and the rotational moment did not significantly change with orthoses. Orthotic management or femoral anteversion did not correlate to pelvic and hip asymmetry. Conclusion: The findings indicate that the correction of the equinus by using orthoses had a variable effect on the asymmetry of the hip and pelvis and internal rotation; both appear to have a multifactorial cause that is not primarily driven by the equinus component.
Gastrointestinal Involvement in Children with Systemic Lupus Erythematosus
Authors: Mauro Angela , Giani Teresa , Di Mari Clelia , Sandini Martina , Talenti Antonella , Ansuini Valentina , Biondi Luigi , Di Nardo Giovanni , Bernardo Luca
Published: February 2023

Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder. When it presents before the age of 18 years (childhood-onset systemic lupus erythematosus, cSLE), the disease course tends to be more severe with a higher rate of organ involvement and requires an early diagnosis. Gastrointestinal involvement in cSLE is rare and scarcely reported in the literature. Any organ of the gastrointestinal system may be affected, either as a direct consequence of the disease, as a subsequent complication, or as an adverse drug event. Abdominal pain is the most common GI symptom, it can be diffuse or well localized, and can underline different conditions such as hepatitis, pancreatitis, appendicitis, peritonitis, or enteritis. cSLE may have an alteration of the intestinal barrier with features of protein-losing enteropathy or, in genetically predisposed patients, may develop associated autoimmune disorders such as Coeliac Disease or Autoimmune Hepatitis. The aim of this manuscript is to provide a narrative review of gastrointestinal manifestations in cSLE focused on hepatic, pancreatic, and intestinal involvement. A comprehensive literature search based on the PubMed database was performed.
Story to Change Culture on Early Childhood in Australia
Authors: Kendall-Taylor Nathaniel , Michaux Annette , Cross Donna , Forde Karen
Published: February 2023

The goal of the article is to support the early childhood sector’s efforts to increase the salience of early childhood as a social issue and change policy and practice to better support young children and their families. Cultural models shape how people think about social issues and support solutions. Changing how issues are framed—how they are presented, positioned and focused—can help shift these models and facilitate culture change. Using mixed methods research, we identified cultural models that members of the Australian public use to think about early childhood and compared these mindsets to concepts that the sector seeks to advance. This revealed a set of gaps in understanding that make it difficult for the sector to advance its agenda. We then designed and tested framing strategies to address these challenges and improve the salience of early childhood as a social issue, increase understanding of key concepts and build support for policies, programs and interventions. Findings point to strategies that advocates, service providers and funders can use to communicate more effectively about the importance of the early years.
Oxidative Stress in Assisted Reproductive Techniques, with a Focus on an Underestimated Risk Factor
Authors: Mauchart Péter , Vass Réka Anna , Nagy Bernadett , Sulyok Endre , Bódis József , Kovács Kálmán
Published: February 2023

Based on current findings, the presence of oxidative stress has a significant impact on the quality of gametes and embryos when performing assisted reproductive techniques (ART). Unfortunately, in vitro manipulation of these cells exposes them to a higher level of reactive oxygen species (ROS). The primary goal of this review is to provide a comprehensive overview of the development of oxidative stress in female and male reproductive systems, as well as in the case of the pre-implantation embryo and its environment. This review also focuses on the origins of ROS and the mechanisms of oxidative stress-induced damage during ART procedures. A well-known but underestimated hazard, light exposure-related photo-oxidation, is particularly concerning. The effect of oxidative stress on ART outcomes, as well as the various strategies for preventing it, are also discussed. We emphasize the role and significance of antioxidants and light protection including forms, functions, and mechanisms in the development of gametes and embryos in vivo and in vitro.
Dynamic Modal Analyses of Building Structures Employing Site-Specific Response Spectra Versus Code Response Spectrum Models
Authors: Khatiwada Prashidha , Hu Yiwei , Lumantarna Elisa , Menegon Scott J.
Published: February 2023

This paper is aimed at giving structural designers guidance on how to make use of elastic site-specific response spectra for the dynamic modal analysis of a structure in support of its structural design. The use of response spectra in support of the pushover analysis of an RC building forming part of the non-linear static analysis procedure (that can be used to predict seismic demand without relying on the code-stipulated default R factor) is also presented. Seismic analysis of structures based on the use of site-specific response spectra can help to achieve a more optimised, and cost-effective, structural design compared to the conventional approach employing a response spectrum model stipulated by the code for different site classes. Currently, the methodology is only adopted in major projects in which enough resources are available to engage experts who are skilled in operating the procedure; thus, the use of site-specific response spectra in structural engineering practice is still limited despite the merits of the procedure. Deriving a site-specific response spectrum requires a database of representative ground motion records to be developed. Extra analytical tasks to be undertaken include the processing of bore log data, site response analyses, and selection/scaling of bedrock accelerograms for input into site response analyses. Guidelines for implementing this design methodology are currently lacking. To promote the wide adoption of site-specific seismic design, this article presents the procedure for developing the required site-specific design spectra, as well as guidelines for applying these spectra for seismic design based on analyses of linear, or nonlinear, models of the building. Non-linear analysis can be accomplished by dealing with macroscopic models as illustrated in a case study.
Research Progress in Metals and Alloys by Thermal Layering and Deposition
Authors: Srivastava Ashish Kumar , Dixit Amit Rai
Published: February 2023

Over the last 20 years, because of their superior hardness, chemical stability, and outstanding oxidation barrier, many coating systems have now been extensively researched using various deposition processes and employed for wear-resistant protection [...]
Characterization of Argon/Hydrogen Inductively Coupled Plasma for Carbon Removal over Multilayer Thin Films
Authors: Wang Yi , Gehring Tim , Jin Qihao , Dycke Jan , Kling Rainer
Published: February 2023

Inductively coupled plasma with an argon/hydrogen (Ar/H2) mixture is a potential solution to many surface treatment problems, especially when encountering carbon contamination in optical X-ray and extreme ultraviolet instruments. Removing carbon contamination on multilayer thin films with Ar/H2 plasma extends the lifetime of the above devices. To further investigate the reaction between plasma and carbon, both optical emission spectroscopy and finite element method with multiphysics fields were employed. The results demonstrated that the intensities of the Balmer lines were in good agreement with the densities of the radical hydrogen atoms from the simulation model, showing a dependence on the mixing ratio. At an electrical input power of 165 W and a total pressure of 5 Pa, an optimum mixing ratio of about 35 ± 5 % hydrogen produced the highest density of hydrogen radicals, coinciding with the highest carbon removal rate. This shows that the carbon removal with Ar/H2 plasma was mainly controlled by the density of hydrogen radicals, and the mixing ratio showed a significant impact on the removal rates.
Gas Desorption and Secondary Electron Emission from Graphene Coated Copper Due to E-Beam Stimulation
Authors: Feng Guobao , Song Huiling , Li Yun , Li Xiaojun , Xie Guibai , Zhuang Jian , Liu Lu
Published: February 2023

The gas desorption and secondary electron multiplication induced by electron bombardment tend to induce severe low-pressure discharge effects in space microwave device cavities. Nevertheless, few studies have focused on both secondary electron emission and electron-stimulated gas desorption (ESD). Although the suppression of secondary electrons by graphene was found to be better in our previous study, it is still unclear whether the surface modification of graphene, which brings about different interfacial states, can also be manifested in terms of ESD. The deep mechanism of gas desorption and secondary electron emission from this extremely thin two-dimensional material under electron bombardment still needs further investigation. Therefore, this paper investigates the mechanism of graphene modification on Cu metal surface on the gas release and secondary electron emission properties under electron bombardment. The surface states of graphene-modified Cu were characterized, and the ESD yield and secondary electron yield of Cu/GoCu were investigated using a self-researched platform and analyzed using molecular dynamics simulations and electron Monte Carlo simulations. The results of the study showed that the most released component on the Cu surface under the bombardment of electrons was H2O molecules, while the most released component on the GoCu surface was H2 molecules. The graphene-modified samples showed a significant suppression effect on the secondary electron yield and ESD only in the low-energy region below 400 eV. This study can provide a valuable reference for suppressing low-pressure discharge and multipactor phenomena in space microwave components.
Type and Sources of Salt Efflorescence in Painted Stone Carvings from Pujiang Museum, Sichuan, China
Authors: Song Quanshuai , Zha Jianrui , Bai Yulong , Chen Long , Zhang Yao , Guo Hong
Published: February 2023

Painted stone carvings from Pujiang Museum in Chengdu were excavated from the Ming tombs near to Chengdu Metro Line 7. The Ming burial sites were the eunuch graves of the Shu King, and their tomb was constructed mostly of stone and decorated with paintings and carvings on its surface, which are of great value. However, during their burial, these painted stone carvings suffered significant salt damage. In this research, we performed optical microscope (OM) analysis, Raman spectra (RAM), ion chromatography (IC) analysis, X-ray fluorescence spectroscopy (XRF), X-ray powder diffraction (XRD), and petrographic microscopy (PM) to clarify the salt composition and influence. According to the results, the majority of the salt on the painted layer is CaSO4·2H2O. Before excavation, interaction between acid rain, soil, and groundwater created salt efflorescence on the paint layer’s surface. The deterioration of the paint layer caused by gypsum was divided into two stages: before excavation and during in situ preservation. This research provides a foundation for the removal and prevention of salt efflorescence.
Outcomes and Economic Evaluation in Delayed Two-Stage Breast Reconstruction in Romania: The Influence of Radiotherapy
Authors: Porosnicu Andrei Ludovic , Riza Stefania Mihaela , Stanculescu Ioana Antonia , Parasca Sorin Viorel , Jecan Cristian Radu , Sinescu Ruxandra Diana
Published: February 2023

The current paper is a retrospective cohort study conducted on sixty-seven patients who underwent two-stage breast reconstruction over a 5-year period (2015–2020). Forty-one (61.2%) patients received radiotherapy (RT group), and twenty-six (38.8%) did not (non-RT group). Data regarding patients, oncological therapies, type of reconstruction, time of hospitalization, complications, and costs were collected. The statistical analysis was performed using IBM SPSS Statistics 25. General complications were noted for 18 patients (43.9%) in the RT group and for 7 patients (26.9%) in the non-RT group. Major complications were observed only in the first group (five patients–12.2%). The mean time of hospitalization in the RT group was 14.83 days for patients with complications versus 9.83 days for those without complications and 15.5 days versus 8.63 days, respectively, in the non-RT group. The mean cost for patients without complications was 235.64 euros, whereas the cost for patients with complications was 330.24 euros (p = 0.001). Radiation therapy can affect the overall outcome by increasing the risk of complications and increasing costs; however, our paper shows that the association of alloplastic reconstruction in patients with radiotherapy can be performed safely and with low costs in carefully selected patients.
A Critical Checklist of the Marine Fishes of Malta and Surrounding Waters
Authors: Borg Joseph A. , Dandria David , Evans Julian , Knittweis Leyla , Schembri Patrick J.
Published: February 2023

A critical review of marine fishes from Malta (Central Mediterranean) recorded up to December 2022 in the technical and semi-popular literature, during the Mediterranean International Trawl Survey (MEDITS), and in commercial fisheries landings data, was undertaken with the main aim of producing a checklist of species whose occurrence in the seas around the Maltese Islands could be authenticated. This review also served to generate two other lists: one of the species whose occurrence around the islands is probable or possible but which require confirmation, and a second list of previously reported species whose occurrence was deemed highly unlikely and which were hence excluded; the reasons for such exclusion are given. A total of 412 species were confirmed as occurring in Maltese waters, 53 species were listed as requiring confirmation, and 78 species were excluded. Of the species whose occurrence around the Maltese Islands was confirmed, 370 were native; 17 were non-established aliens; seven were established aliens; three were non-established Atlantic immigrants; five were established Atlantic immigrants; nine were non-established cryptogenic; and one was an established cryptogenic. The 412 confirmed species from the Maltese Islands represent 54% of the Mediterranean fish species that have been recorded in recently published works. Therefore, considering the geographical location of the islands at the centre of the Mediterranean, they provide a presumed ideal siting for a good representation of the marine ichthyological fauna. The Maltese checklist appears to still be short of many fish species that probably occur locally and have yet to be added to the present confirmed list. Nevertheless, the present review serves as a good indication of the current situation of the Maltese fish fauna, also noting that checklists for the group from neighbouring countries are somewhat outdated and require review and updating.