bluuebunny/crossref_metadata_2025 huggingface dataset:
Anudamientos y cabos sin atar
Authors: López Fittipaldi Marilín
Published: July 2024

Con base en una investigación socioantropológica más amplia, realizada entre los años 2010 y 2021, en este artículo problematizamos las experiencias que construyen estudiantes jóvenes y adultos/as que asisten a una escuela de gestión social creada por una organización política de la ciudad de Rosario (Argentina). Particularmente, describimos aquellos sentidos y prácticas desplegados en la cotidianeidad escolar que, en su propia concepción, contribuyen a forjar cierto involucramiento con el proyecto colectivo. Enfocamos, también, las resignificaciones que se generan cuando los/as estudiantes finalizan sus estudios, momento que experimentan de manera disruptiva ya que la posibilidad de continuar vinculados al proyecto político educativo pocas veces se concreta. Sostenemos que en estas experiencias se tejen procesos de formación subjetiva que resultan dinámicos, contradictorios e inacabados, constreñidos por las condiciones materiales en que los sujetos desenvuelven su vida y sometidos a reformulaciones en el devenir temporal.
O que o amor pode suportar?
Authors: Rangel Everton
Published: July 2024

Este artigo tem como objetivo descrever de que maneira foi erguido e sustentado o amor de uma mulher pobre e grávida, Célia, por um homem, Tonico, também pobre, que ela não tinha certeza se era ou não um estuprador e é o pai do seu filho. Tonico conheceu Célia em um pagode no centro do Rio de Janeiro, enquanto cumpria pena em um presídio semiaberto, e era justamente sobre o crime que teria cometido que ele mais mentia para ela. Visando explicitar que a mentira está diretamente relacionada à produção do laço amoroso, primeiro discorrerei sobre algumas noções de amor e, em seguida, mobilizarei aquela que me parece mais próxima aos meus dados para discutir a noção de vulnerabilidade, bem como a de mentira e seus efeitos. Descrevo os custos subjetivos de tentar amar e crer em um noivo que parece mentir o tempo todo, visando sugerir que o amor e a mentira se vinculam à produção de vulnerabilidade. Defendo que existe um nexo entre amor, mentira e vulnerabilidade, que incitado e marcado pela prisão, produz família de forma específica.
Doença de Behçet - uma revisão de literatura
Authors: Magalhães Ana Clara Felipe , Pesah Larissa Karen Fernandes Rodrigues , Pereira Luísa Bambirra , Farias Nayron Arthur Correia , Lopes Sarah Ferreira
Published: July 2024

A Doença de Behçet é uma condição inflamatória crônica que se manifesta através de uma variedade de sintomas, afetando múltiplos sistemas do corpo. Entre as manifestações dermatológicas, destacam-se as úlceras orais recorrentes, que são frequentemente o primeiro sinal da doença. Além disso, a condição pode causar lesões cutâneas como eritema nodoso e pseudofoliculite. Essas manifestações cutâneas não só impactam a qualidade de vida dos pacientes, mas também são indicativas da atividade inflamatória subjacente da doença. No âmbito ginecológico, pode apresentar-se através de úlceras genitais dolorosas, que são comuns e podem ser debilitantes para as mulheres. Essas úlceras, semelhantes às orais, tendem a ser recorrentes e podem causar cicatrizes. Além disso, a inflamação pode afetar outras áreas do trato genital, levando a dor e desconforto crônicos. No contexto obstétrico, a doença apresenta desafios significativos, pois pode estar associada a complicações como abortos espontâneos e partos prematuros. A inflamação sistêmica pode impactar a gravidez, exigindo um monitoramento rigoroso e um manejo cuidadoso da paciente gestante. O tratamento da Doença de Behçet requer uma abordagem multidisciplinar, envolvendo dermatologistas, ginecologistas, reumatologistas, e, quando necessário, outros especialistas como oftalmologistas e neurologistas. A terapia imunossupressora e anti-inflamatória é frequentemente necessária para controlar os sintomas e prevenir exacerbações. Quanto às intervenções cirúrgicas, estas são indicadas em casos específicos, como em complicações vasculares graves ou em lesões que não respondem ao tratamento convencional. A cirurgia pode ser necessária para tratar aneurismas, tromboses venosas ou outras complicações vasculares associadas. Além disso, em casos de úlceras genitais severas, a intervenção cirúrgica pode ser uma opção para aliviar a dor e prevenir infecções secundárias. Por fim, o manejo adequado da doença, combinando tratamentos médicos e, quando necessário, intervenções cirúrgicas, é fundamental para melhorar os desfechos e proporcionar uma melhor qualidade de vida aos afetados por essa condição crônica.
O conhecimento dos profissionais de saúde sobre o conceito e os princípios dos cuidados paliativos: revisão integrativa
Authors: Sousa Silvana Maria de Oliveira , Alves Elis Regina Bastos , Machado Laura Emanuela Pinheiro , Teixeira Raquel Oliveira Piancó , Cavalcante Kilvia Rodrigues Gomes , Santos Francisca Alice Almeida , Matos Lyllian Millena da Costa , Martins Laércia Ferreira
Published: July 2024

Cuidados Paliativos promovem qualidade de vida aos pacientes/familiares com doenças ameaçadoras à vida, através da prevenção, alívio do sofrimento e dor, identificação precoce, avaliação e tratamento dos problemas físico-psico-social-espirituais. Esse conceito vem sendo amplamente discutido nas últimas décadas o que nos faz questionar: Os profissionais de saúde conhecem o conceito e princípios dos cuidados paliativos conforme preconizado pela Organização Mundial de Saúde? Objetivou-se avaliar conhecimentos/conceito em cuidados paliativos pelos profissionais de saúde descritos na literatura nacional nos últimos anos. Por meio de Revisão integrativa da literatura buscou-se artigos indexados entre 2014-2019 nas bases: Biblioteca Virtual de Saúde (BVS), Scientific Electronic Library Online (SciELO) e Google Scholar. Utilizou-se os descritores “Conceito”, “Conhecimento”, “Cuidados Paliativos e suas combinações com diversas categorias de profissionais de saúde. Após aplicar critérios em quase 100mil resultados, analisou-se em 25 artigos o conhecimento de 1391 diferentes profissionais de saúde. Os estudos evidenciaram diferentes graus de desconhecimento sobre conceito e princípios dos cuidados paliativos, gerando confusão e relacionando à assistência prestada somente no final da vida. 100% dos estudos mencionaram alívio da dor e sintomas físicos. A assistência aos pacientes em paliação deve proporcionar cuidado para qualidade de vida, com assistência interdisciplinar; participação familiar; cuidados contínuos à pessoa nas dimensões bio-psico-socio-espirituais. Os estudos com profissionais de unidades oncológicas apresentaram melhor compreensão disto. Foi recorrente o reconhecimento da importância da equipe multidisciplinar. Paradoxalmente, em 11(44%) dos estudos o médico é considerado profissional protagonista e unicamente atuante em todo processo. Preocupa-se constatar menção à formação deficiente, despreparo técnico/emocional dos profissionais com as situações e com pacientes em paliação em quase 100% estudos. Assim, infere-se confusão e desconhecimento sobre o conceito de cuidados paliativos que é amplo e complexo, originando inseguranças para profissionais de saúde que não têm preparo adequado desde a graduação.
Efetividade dos testes rápidos de sífilis em gestantes na prevenção de Sífilis Congênita: análise temporal de dados epidemiológicos antes e depois da implementação do rastreio pré natal no Estado de Minas Gerais
Authors: Coutinho Lauren Cangussu , Gonçalves Gabriella Campos Domingos , Almeida Vitor Lanza Avelar
Published: July 2024

A sífilis gestacional (SG) é uma doença de notificação compulsória que se apresenta como um grave problema de saúde pública no Brasil, devido à grande incidência e às consequências que pode desencadear tanto na gestante quanto no feto, culminando na sífilis congênita (SC). Em 2012 o Ministério da Saúde instituiu a obrigatoriedade da inclusão de Testes Rápidos (TR) de sífilis no pré-natal de gestantes, para que sejam identificadas e tratadas, prevenindo que o feto seja infectado. Este estudo objetiva avaliar a efetividade dessa implementação no Estado de Minas Gerais, comparando o número de casos registrados antes (2007-2011) e depois (2015-2019) das testagens de rotina e o impacto da medida para contenção dos casos de SC. Para tanto, foi elaborado estudo epidemiológico descritivo quantitativo, valendo-se de dados secundários obtidos do SINAN. Para análise estatística os dados foram analisados no programa STATA e utilizados testes de Shapiro Wilk, Teste-T e Mann-Whitney. Observou-se significância estatística entre casos confirmados de SG e SC no período (p=0,0000), além de diferença significativa entre as médias antes e depois dos TR, tanto de SG (p=0,0001) quanto de SC (p=0,0000). A transmissão vertical reduziu em 24,29% após as testagens pré-natais e o número de diagnósticos de SG aumentou em 1018,8% no período. Conclui-se que o uso de TR para detecção de SG foi efetivo em aumentar os diagnósticos da população em risco, além de resultar em menor taxa percentual de fetos infectados, embora ainda seja preciso assegurar que mais gestantes sejam tratadas adequadamente e em tempo oportuno.
Abordagens de triagem e rastreamento para identificação precoce do pé diabético
Authors: Meira Caroline Ferreira , Silva Jessica Merielen Pereira da , Lopes Kaylane de Oliveira , Gallinari Leticia Marques , Ferreira Mirelle dos Santos , Carvalho Raianny Gallinari , Oliveira Elen Cristiane Doná de , Mendonça Telma Fernanda , Gomes Giseli da Silva Toquetto , Sakamoto Sabrina Ramires
Published: July 2024

O diabetes mellitus (DM) é caracterizado por níveis elevados de glicose no sangue (hiperglicemia), resultante de uma disfunção na produção ou na ação da insulina. A hiperglicemia persistente associada ao DM pode levar a uma série de complicações graves a longo prazo, tanto macrovasculares quanto microvasculares. O pé diabético refere-se a uma série de condições que afetam os pés de pessoas com diabetes, incluindo úlceras crônicas, infecções e danos nos nervos e nos vasos sanguíneos. Devido à neuropatia diabética (dano nos nervos) e à doença vascular periférica (dano nos vasos sanguíneos), as pessoas com diabetes podem perder a sensibilidade nos pés e ter uma circulação sanguínea comprometida. Este artigo teve como objetivo avaliar as abordagens de triagem e rastreamento para identificação precoce do pé diabético. Tratou-se de uma revisão integrativa da literatura, realizada entre os meses de abril a maio de 2024, por meio de uma pesquisa em bases de dados. Foram selecionados oito artigos para compor a presente revisão. A síntese do conhecimento produzido destaca que as tecnologias de cuidado para a prevenção do pé diabético na APS são desenvolvidas por meio da atuação de uma equipe multiprofissional, com destaque para o papel do enfermeiro. Essas tecnologias abrangem desde o acolhimento do paciente até o uso de máquinas para termometria, visando prevenir essa doença e suas complicações.
Complicações em traqueostomia: manejo clínico e prevenção
Authors: Silva Beatriz Braga , Lacerda Júlia Botelho , Martins Mariana Torres Furtado , Leandro Paula Costa , Corrêa Wagner Pablo
Published: July 2024

O presente artigo tem como objetivo descrever o manejo clínico e prevenção das principais complicações em pacientes com traqueostomia. A traqueostomia é realizada para a abertura direta da traqueia através do pescoço levando ar aos pulmões facilitando a respiração do paciente. Esse procedimento pode ser realizado tanto em caráter de urgência, quanto de forma eletiva e é indicada em casos de obstrução das vias aéreas superiores, necessidade de ventilação prolongada, doenças neuromusculares e presença de secreções pulmonares. Apesar de se tratar de uma intervenção de alta prevalência principalmente para pacientes em Unidades de Terapia Intensiva, seus índices de morbidade têm diminuído ao longo dos anos devido a melhoria das técnicas e dos equipamentos utilizados. As complicações são frequentes em pacientes traqueostomizados, sendo as principais o sangramento pós-operatório, a decanulação acidental, infecções, obstruções, estenose das vias aéreas, e fístula traqueocutânea. Entretanto, muitas dessas complicações são evitáveis com capacitação dos profissionais que executam o procedimento, bem como com cuidados especializados e monitoramento adequado pós procedimento.
Tomografia torácica em Pneumonia por COVID-19: prevalência dos achados de imagem e fatores preditivos de óbito
Authors: Veras Lara Basilio Medeiros , Eulálio Kelsen Dantas , Martins Eduardo Bruno Lobato , Nogueira Felipe Eduardo Lages Veras , Romão Mateus Sampaio Cruz , Lopes Ione Maria Ribeiro Soares , Landim Maurício Batista Paes , Ribeiro João Luiz Vieira
Published: July 2024

Objetivo: Avaliar a prevalência dos achados de imagem em tomografias torácicas em pacientes internados por pneumonia por COVID-19 e identificar alterações associadas a desfecho fatal. Métodos: Foram analisados 295 adultos internados por COVID-19 no período de 01 de março a 31 de Maio de 2021. Foram avaliadas as características clínico-demográficas e comorbidades dos participantes, além das imagens das tomografias torácicas durante a internação e comparou-se os achados encontrados entre os grupos de sobreviventes e não sobreviventes. Resultados: Foram analisadas 371 tomografias, sendo 14,8 % normais. As demais apresentaram as lesões pulmonares típicas de COVID-19, com predomínio de opacidades em vidro fosco periféricas e bilaterais, independente do desfecho. Consolidações alveolares, lesões mistas ( alveolares e em “vidro fosco”), espessamento de septos interlobulares, “pavimentação em mosaico” e bronquiectasias de tração tiveram associação com desfecho de óbito, assim como lesões extensas e com maior porcentagem de acometimento pulmonar, destacando-se uma probabilidade de desfecho fatal 7 vezes maior na presença de acometimento pulmonar superior a 75% ( p<0,01, RP = 7,53 IC95% 3,22-11,44).Conclusão: Algumas alterações tomográficas e a extensão do acometimento pulmonar aumentam a probabilidade de evolução para desfecho fatal durante a internação hospitalar por COVID-19.
Avanços nas opções terapêuticas para o tratamento do Ceratocone
Authors: Santos Luiz Henrique Cunha dos , Amorim Layse Mendes Lima , Uchôa Paloma Duarte Vieira , Uchôa Neto Oton Alves , Leite Felipe Germano Monteiro , Henrique Hialle Ferreira de Freitas , Medeiros Lilian Dantas de , Araújo Ruan Pablo da Costa , Andrade Philipe Fernandes Batista de , Gomes Erick Ricardo Patriota , Silva Wellington Rodrigo da , Silva Ana Beatriz Gomes Ribeiro da , Toscano Daniela Bezerra de Menezes , Cavalcante Nataly Raquel Dantas , Cardoso Maria Vitória Andrade , Rabelo Geraldo Italo Lelis Xavier , Souza Filho Paulo Antônio Corrêa de , Coriolano Thays Dayane Oliveira Araújo , Soares Nathália Oliveira
Published: July 2024

O ceratocone é uma condição ocular progressiva caracterizada pelo afinamento e protrusão em forma de cone da córnea, afetando a visão e a qualidade de vida dos pacientes. Avanços significativos nas opções terapêuticas têm ampliado as escolhas para o manejo desta doença. O cross-linking do colágeno corneano (CXL) emergiu como um tratamento fundamental para estabilizar a córnea e melhorar a acuidade visual, além de mostrar potencial no combate a infecções bacterianas. Procedimentos cirúrgicos como o DALK e o uso de anéis intracorneanos (ICRS) têm proporcionado resultados positivos, preservando a integridade corneana e melhorando a qualidade óptica. Inovações como a implantação assistida por laser femtosegundo de lentículo estromal corneano representam avanços promissores para o tratamento cirúrgico. Essas abordagens personalizadas visam não apenas estabilizar a progressão do ceratocone, mas também melhorar substancialmente a qualidade de vida dos pacientes.
Aggravated Ulcerative Colitis via circNlgn-Mediated Suppression of Nuclear Actin Polymerization
Authors: Du William W. , Zhou Chi , Yang Hui , Wen Shuoyang , Chen Yu , Chen Eric X. , Yang Xiuwei H. , Li Feiya , Du Kevin Y. , Yuan Hui , Ye Ting , Qadir Javeria , Yang Burton B.
Published: July 2024

Colitis is a chronic bowel disease characterized by damage to the lining of the large intestine, with its precise underlying causes remaining incompletely understood. In this study, we provide evidence that circular RNA circNlgn plays a pivotal role in promoting the development of colitis. Colitis patients produce significant higher levels of circNlgn. Transgenic mice expressing circNlgn exhibit heightened susceptibility to colitis development and progression, primarily attributed to the presence of the protein isoform Nlgn173 encoded by circNlgn. Nlgn173 undergoes translocation into cell nuclei, where it interacts with actin, impeding the binding of actin-related protein 2 and 3 (Arp2/3) complex to actin molecules. Consequently, this leads to a reduction in actin polymerization. Mechanistically, Nlgn173 enhances tyrosine-53 phosphorylation of nuclear actin, diminishing its capacity to interact with the Arp2/3 complex and causing a decrease in filamentous actin levels. These alterations in actin dynamics result in inhibited cell cycle progression, increased apoptosis, and decreased proliferation of colonic epithelial cells, thereby exacerbating colitis development and progression. In contrast, the silencing of circNlgn or the targeted inhibition of Nlgn173 translation and nuclear translocation leads to the promotion of nuclear actin polymerization, enhanced cell survival, and reduced apoptosis and ultimately improves the outcome of colitis in vivo. Interestingly, nuclear actin polymerization is highly related with expression of PIAS3, which modulates signal transducer and activator of transcription 3 and NF-κB activity in colitis. Strategies such as circNlgn knockdown and targeting nuclear actin polymerization of the colonic epithelium may explore a novel avenue for acute ulcerative colitis clinical intervention.
Anti-TNFR2 Antibody-Conjugated PLGA Nanoparticles for Targeted Delivery of Adriamycin in Mouse Colon Cancer
Authors: Li Ping , Yang Yang , Wang Yifei , Zheng Jingbin , Chen Fengyang , Jiang Mengmeng , Chou Chon-kit , Cong Weihong , Li Zongjin , Chen Xin
Published: July 2024

High levels of tumor necrosis factor receptor type II (TNFR2) are preferentially expressed by immunosuppressive CD4
+
Foxp3
+
regulatory T cells (T
regs
), especially those present in the tumor microenvironment, as initially reported by us. There is compelling evidence that targeting TNFR2 markedly enhances antitumor immune responses. Furthermore, a broad spectrum of human cancers also expresses TNFR2, while its expression by normal tissue is very limited. We thus hypothesized that TNFR2 may be harnessed for tumor-targeted delivery of chemotherapeutic agents. In this study, we performed a proof-of-concept study by constructing a TNFR2-targeted PEGylated poly(
dl
-lactic-co-glycolic acid) (PLGA-PEG) nanodrug delivery system [designated as TNFR2-PLGA-ADR (Adriamycin)]. The results of in vitro study showed that this TNFR2-targeted delivery system had the properties in cellular binding and cytotoxicity toward mouse colon cancer cells. Further, upon intravenous injection, TNFR2-PLGA-ADR could efficiently accumulate in MC38 and CT26 mouse colon tumor tissues and preferentially bind with tumor-infiltrating T
regs
. Compared with ADR and ISO-PLGA-ADR, the in vivo antitumor effect of TNFR2-PLGA-ADR was markedly enhanced, which was associated with a decrease of TNFR2
+
T
regs
and an increase of IFNγ
+
CD8
+
cytotoxic T lymphocytes in the tumor tissue. Therefore, our results clearly show that targeting TNFR2 is a promising strategy for designing tumor-specific chemoimmunotherapeutic agent delivery system.
O processo oncológico que as mulheres sofrem em condições pandêmicas
Authors: Betancourth Daniela Bejarano , Angelis Claudia M De , Güerci Alba M
Published: July 2024

Introducción y objetivos: en atención al análisis de la Organización Panamericana de la Salud, el cáncer es la segunda causa de muerte en América Latina y se presume que esta situación empeore en las próximas décadas, dado el aumento de casos atribuido al estilo de vida moderno y envejecimiento poblacional. Dentro de este contexto, el cáncer de mama constituye el tumor más frecuente y principal causa de muerte oncológica del sexo femenino y el cáncer cérvico-uterino es un problema cardinal y preocupante en la salud pública de las Américas. Si bien estas patologías pueden exhibir un manejo diagnóstico y terapéutico eficaz, el escenario pandémico actual ha llevado a eludir tanto la detección precoz como el tratamiento oportuno, interfiriendo así con su control adecuado y exitoso. Así, nuestro objetivo fue describir la influencia de la pandemia en el abordaje y manejo terapéutico de los tumores más frecuentes y conspicuos que atraviesa el género femenino.
Metodología: se realizó un estudio descriptivo, en términos de valorar la frecuencia y distribución de consultas y tratamientos por patologías oncológicas femeninas, en un centro asistencial de la ciudad de La Plata, Argentina (Centros Integrados de Oncología, Terapia Radiante S.A), realizadas desde el 20 de marzo de 2019 al 20 de marzo de 2021 (N=864 pacientes). El análisis de los datos se realizó mediante el paquete estadístico Stata 11.1.
Resultados y Conclusiones: se observó una disminución significativa de consultas por abordaje terapéutico (p<0.002), y consecuentemente un descenso en el número de tratamientos de radioterapia, principalmente con intención curativa, como así también una demora en el inicio de los mismos (RR= 6.22) durante el período pandémico. En adición se observó tendencia hacia el aumento de tratamientos paliativos.
La disminución de la demanda de los servicios de oncología debido al confinamiento y la renuencia de algunos pacientes a acudir a las consultas ambulatorias o a los centros de tratamiento, tuvo impacto negativo en el acceso en tiempo y forma al tratamiento curativo del cáncer en el sexo femenino. Junto a la detección temprana de la enfermedad, el abordaje terapéutico oportuno brinda la posibilidad de terapias menos invasivas, instaurando un mejor pronóstico y mejorando la calidad de vida de las pacientes que atraviesan un proceso oncológico.
Cultural Clash: Investigating How Entrepreneural Characteristics and Culture Diffusion affect International Interns’ Competency
Authors: Ligia Emila , Iskandar Kurniawaty , Surajaya I Ketut , Bayasut Mahir , Jayanagara Oscar , Mizuno Kosuke
Published: July 2024

The world today is highly interconnected. To address the manpower shortage in Japan and the surplus in Indonesia 30 years ago, both countries developed an internship program, "Ginou Jisshu." During the internship, participants with Indonesian culture-based individual characteristics are exposed to Japanese work culture. This study aimed to investigate how interns' individual characteristics and their assimilation of Japanese work culture improve their competency and competitiveness, considering self-efficacy as a moderating factor. Using a quantitative research method, data from 400 internship alumni across 38 provinces in Indonesia were collected through Google Form questionnaires and analyzed using PLS-SEM. Out of 10 proposed hypotheses, all direct effect hypotheses were accepted, and 3 of the moderation hypotheses were accepted, while 2 were rejected. This study introduces a novel paradigm where any positive effect, regardless of statistical significance, is considered beneficial. It suggests that resolving issues, even minor ones, can amplify positive effects and mitigate negative effects. The findings reveal that individual characteristics and Japanese work culture positively affect competency and competitiveness, and competency further enhances competitiveness. Self-efficacy strengthens the impact of individual characteristics and Japanese work culture on competency, as well as the impact of Japanese work culture and competency on individual competitiveness. However, it weakens the effect of individual characteristics and competency on individual competitiveness.
Psychological Aspects of Awake Surgery in Pediatric Neurosurgery
Authors: Талабаев М.В. , Чурило Н.В. , Соловьева А.Ю.
Published: July 2024

Цель. Изучить психоэмоциональную переносимость операций в сознании у детей и выявить признаки развития посттравматического стрессового расстройства. Материалы и методы. Проанализированы психоэмоциональные аспекты, связанные с перенесенной операцией в сознании по поводу новообразований, расположенных в функционально значимых отделах коры головного мозга у 17 пациентов, проходивших обследование и нейрохирургическое лечение в РНПЦ неврологии и нейрохирургии с 2016 по 2022 год. В процессе исследования для оценки психоэмоционального состояния была разработана психометрическая шкала Лайкерта. Результаты. Анализ заполнения шкал Лайкерта показал, что до операции пациентов с высоким уровнем баллов психоэмоционального состояния было 7 (46,6%) человек, средним – 4 (26,7%), низким – 4 (26,7%) человека. Большинство, 73,3% пациентов, находились в достаточно комфортном психоэмоциональном состоянии. Послеоперационное тестирование, проведенное через 9–12 месяцев после операции, показало, что высокий уровень сохранился у 6 (40%) испытуемых, средний у 6 (40%), низкий у 3 (20%). Заключение. Наши результаты показывают, что операции в сознании у пациентов детского возраста безопасны и не явились значительным психотравмирующим событием.

Purpose. To study the psycho-emotional tolerance of awake operations in children and to identify signs of the development of post-traumatic stress disorder. Materials and methods. The psycho-emotional aspects associated with undergoing awake surgery for eloquent brain tumors were analyzed in 17 patients who underwent examination and neurosurgical treatment at the Republican Scientific and Practical Center of Neurology and Neurosurgery from 2016 to 2022. During the study, a psychometric Likert scale was developed to assess the psycho-emotional state. Results. Analysis of the completion of Likert scales showed that before surgery there were 7 (46.6%) patients with a high level of scores, 4 (26.7%) with an average level of scores, and 4 (26.7%) with a low level of scores. The majority of 73.3% of patients were in a fairly comfortable psycho-emotional state. Postoperative testing, carried out 9–12 months after surgery, showed that the high level remained in 6 (40%) subjects, medium in 6 (40%), low in 3 (20%). Conclusion. Our results demonstrate that awake surgery in pediatric patients is safe and was not a significant traumatic incident.
Drug-Resistant Epilepsy: Current State of the Problem and Prospects Treatment in Belarus
Authors: Марьенко И.П. , Лихачев С.А. , Костюкевич Е.П. , Терехов В.С.
Published: July 2024

Введение. Проблема фармакорезистентной эпилепсии (ФРЭ) остается на сегодняшний день до конца нерешенной. Электростимуляция блуждающего нерва относится к немедикаментозным видам терапии ФРЭ. Стимулятор блуждающего нерва (vagus nerve stimulator – VNS) используется в качестве вспомогательного метода лечения для снижения частоты приступов у пациентов с ФРЭ. Цель. Оценить результаты VNS-терапии у пациентов с ФРЭ, находящихся под динамическим наблюдением с 2014 по 2024 г. Материалы и методы. В исследование были включены 53 пациента (мужчин – 22 (42%), женщин – 31 (58%), средний возраст 31 [33,7; 28,4] год) с ФРЭ и с имплантированной VNS-системой, находящихся под динамическим наблюдением с 2014 по 2024 г. Результаты. Применение VNS-терапии ФРЭ демонстрирует снижение частоты эпиприступов более чем у трети пациентов – в 19 (36%) случаях из 53, из них в 8 (15%) случаях наблюдалось снижении частоты серий приступов. Заключение. Полученные результаты демонстрируют перспективность использования VNS-терапии.

Introduction. The problem of Drug-resistant epilepsy (DRE) remains today is not fully resolved. Electrical stimulation of the vagus nerve is a non-drug type of EEG therapy. Vagus nerve stimulator VNS therapy is used as an adjuvant treatment to reduce the frequency of attacks in patients with EEG. Purpose. To evaluate the results of VNS therapy in patients with EEG who were under dynamic observation from 2014 to 2024. Materials and methods. The study included 53 patients (men – 22 (42%), women – 31 (58%), average31 [33.7; 28.4] years) whit DRE and an implanted VNS system, who were under dynamic observation from 2014 to 2024. Results. The use of VNS-therapy DRE demonstrates a decrease in the freguency of epileptic attacks in more than a third of patients in 19 (36%) cases out of 53, of which in 8 (15%) cases there was a decrease in the frequency of series of attacks. Conclusion. The results obtained show promise use of VNS therapy.
Symptomatic pigment dispersion with intraocular pressure elevation attributed to intracameral moxifloxacin after open-globe injury
Authors: Chanza Yamiko Jessica , Marando Catherine Marie , Tieger Marisa , Boland Michael Vincent
Published: July 2024

Background: Intracameral moxifloxacin is commonly used following intraocular surgery to prevent endophthalmitis. Pigment dispersion is a rare complication of moxifloxacin use that has mainly been reported following systemic administration.
Case presentation: We report a case of unilateral pigment dispersion three weeks after open-globe repair with intracameral moxifloxacin presenting with pain, redness, photophobia, elevated intraocular pressure, marked pigment liberation, new iris transillumination defects and pigment deposits on the anterior iris surface.
Conclusion: Symptomatic unilateral pigment dispersion with IOP elevation following intracameral moxifloxacin is a rare entity, but it is a crucial complication for clinicians to be aware of as intracameral antibiotic use following intraocular surgery becomes more frequent.
Menanamkan Karakter Peduli Lingkungan Berintegrasi dengan Ilmu Biologi dan Al-Qur’an di SDN 55 Prabumulih
Authors: Handian Martin , Nizar Harisman , Arisandi Bustomi
Published: July 2024

Program pengabdian masyarakat dalam bentuk pendidikan ini atas dasar kerjasama mahasiswa Kuliah Kerja Nyata Universitas Islam Negeri Raden Fatah Palembang dengan Desa Gunung Kemala, Kecamatan Prabumulih Barat, Kota Palembang, Provinsi Sumatera Selatan untuk memberikan edukasi atau penyuluhan terkait bagaimana menanamkan karakter peduli dan menjaga lingkungan sejak dini berintegrasi dengan ilmu biologi dan l-qurâ€™an pada anak-anak di SDN 55 Prabumulih. Kegiatan edukasi ini dilakukan karena melihat kondisi kurangnya sadar dalam menjaga lingkungan. Tujuan dari edukasi ini adalah agar anak-anak memiliki sifat menjaga lingkungan dan membuang sampah pada tempatnya melalui pemahaman Al-Qurâ€™an yang berkaitan dengnngan ilmu biologi sejak dini. Metode yang digunakan dalam penelitian ini adalah ceramah dan tanya jawab dengan menggunakan pendekatan pemahaman Al-Qurâ€™an dan ilmu biologi. Hasil dari edukasi ini meningkatkan pemahaman anak-anak bahwa didalam Al-Qurâ€™an terdapat kaitannya dengan ilmu biologi terutama mengenai menjaga lingkungan yang patut kita syukuri atas nikmat Allah SWT yang telah memberikan kita kehidupan.
Membangun Komunitas Entrepreneur Muda Pada Pondok Pesantren DDI Ujung Lare Parepare
Authors: Nur Nikmatullah , Wahyu A. Rio Makkulau , Anwar Wirani Aisiyah
Published: July 2024

Bentuk Pengabdian kepada Masyarakat ini merupakan program layanan masyarakat ini dilakukan untuk mampu mengembangkan potensi kewirausahaan santri di Pesantren DDI Ujung Lare sehingga mereka memiliki lifeskill sebagai modal hidup di tengah-tengah Masyarakat dengan menggunakan Model MBPM (Making, Branding, Packaging, and Marketing) inilah nanti diharapkan mampu mengembangkan potensi kewirausahaan santri di Pesantren DDI Ujung Lare sehingga mereka memiliki lifeskill sebagai modal hidup di tengah-tengah masyarakat.
Empowering Women by Strengthening the Economic Sector and Digital Marketing Through a Women's School in Tambakmenjangan Village
Authors: Erlangga Fajar Sukma , Susilowati Dwi , Santoso Moh Heru Budi
Published: July 2024

The COVID-19 pandemic has had a significant impact on various sectors, including tourism, trade and industry, particularly impacting micro, small and medium enterprises (MSMEs) in Indonesia. According to Adistianingsih and Panjaitan (2022), Indonesia ranks 109th out of 144 countries in terms of women's participation in the economy and entrepreneurial opportunities. This reflects the limited opportunities for women in the world of work and entrepreneurship in Indonesia. Patriarchal culture and negative stigma surrounding the role of women in rural areas exacerbate this problem. This program aims to overcome the low economic participation of women in Tambakmenjangan Village, Lamongan Regency. The problem is the low level of women's empowerment, which has an impact on low levels of education, societal stigma and early marriage. This program utilizes non-formal education and skills training programs for women which are carried out in collaboration with the Lamongan Islamic University student organization. The activity design includes a six-month culinary, fashion and make-up training program for women in Tambakmenjangan Village. The findings show that this program has succeeded in empowering women by increasing their skills and knowledge in various fields. The program also involves partnerships with government agencies, local businesses, and educational institutions. Monitoring and evaluation were carried out to ensure program effectiveness, and workshops were held to disseminate and publicize the results. The implications of this research are very significant because they contribute to the empowerment of women in rural areas and address the gender gap in economic participation.
HUBUNGAN RIWAYAT PEMBERIAN ASI EKSKLUSIF TERHADAP KEJADIAN STUNTING PADA BALITA DI PUSKESMAS GARUDA PEKANBARU
Authors: Herlina Sara , Sartika Wiwi , Qomariah Siti
Published: July 2024

ABSTRAK
Angka stunting di Indonesia masih cukup tinggi, yaitu 21,6%. Salah satu faktor penyebab stunting pada balita adalah asupan makanan yang tidak seimbang, termasuk kurangnya pemberian ASI eksklusif. Penelitian ini bertujuan untuk mengetahui hubungan antara riwayat pemberian ASI eksklusif dan kejadian stunting. Penelitian ini merupakan penelitian observasional analitik dengan desain cross-sectional. Populasi penelitian adalah semua ibu yang membawa balitanya ke Puskesmas Garuda, dengan metode pengambilan sampel accidental sampling sebanyak 225 sampel. Penelitian dilaksanakan di Puskesmas Garuda dari bulan Juni hingga Desember 2023. Instrumen yang digunakan adalah kuesioner dan pengukur tinggi badan. Analisis data dilakukan dengan analisis univariat dan bivariat, menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa mayoritas responden (59,1%) memberikan ASI eksklusif. Sebagian besar responden memiliki status gizi normal, yaitu 164 orang (72,9%). Analisis bivariat menunjukkan bahwa mayoritas responden yang tidak mendapatkan ASI eksklusif memiliki status gizi stunting (34 orang atau 55,7%), sedangkan mayoritas responden yang mendapatkan ASI eksklusif memiliki status gizi normal (106 orang atau 64,6%). Berdasarkan uji statistik chi-square, diperoleh nilai p=0,006, yang menunjukkan adanya hubungan antara riwayat pemberian ASI eksklusif dan kejadian stunting. Disarankan agar ibu memberikan ASI secara eksklusif sesuai dengan kebutuhan gizi anak untuk mencegah stunting.
ANALISIS MANAJEMEN RISIKO KEAMANAN DAN KUALITAS PENGGUNAAN PERALATAN MEDIS DI RUMAH SAKIT UMUM DAERAH ARIFIN ACHMAD PROVINSI RIAU
Authors: Lasiyah Nani , Romi Mulyadi  , Okta Nola Yolanda iriani
Published: July 2024

Peralatan elektro-medis memegang peran penting dalam penyelenggaraan pelayanan kesehatan masyarakat. Pelayanan kesehatan harus didukung oleh perangkat yang tersedia dan berfungsi sesuai UU RI Nomor 56 Tahun 2014 .  Penelitian ini bertujuan menganalisis manajemen risiko terkait peralatan elektro-medis menjamin penggunaan yang aman dan tidak terjadi kecelakaan kerja selama penggunaan baik bagi pasien maupun tenaga medis lainnya sesuai ISO 14971:2019. Metode penelitian kuantitatif dengan pendekatan studi dokumen, lembar ceklist dan wawancara. Berdasarkan hasil penelitian yang dilakukan manajemen risiko peralatan elektro-medis di RSUD Arifin Achmad telah dilaksanakan dengan baik dan sesuai standar ISO 14971:2019 didapatkan presentase kesesuaian manajemen risiko peralatan elektro-medis 100%. Terdapat klasifikasi risiko peralatan elektro-medis low, medium, dan high. Evaluasi risiko dilakukan dengan labelisasi alat medis berbahaya, dan pengendalian risiko dilakukan melalui langkah-langkah preventif, pemeliharaan rutin, serta kalibrasi alat medis. Dokumentasi risiko terdapat kendala anggaran dan biaya dalam proses manajemen risiko peralatan elektro-medis. Berdasarkan dari data yang diperoleh dapat ditarik kesimpulan manajemen risiko peralatan elektro-medis di RSUD Arifin Achmad telah sesuai ISO 14971:2019 bahwa 100% sesuai.
KOMBINASI PUPUK KANDANG KAMBING DAN KALIUM NITRAT (KNO3) TERHADAP PERTUMBUHAN DAN KECEPATAN BERBUNGA JAGUNG MANIS (Zea mays saccharata)
Authors: Fitriyah Nur , Rahmatika Widyana , Melya Contesya Sherlin
Published: July 2024

Zea mays Saccharata (Sweet corn) is a horticultural commodity that is have high carbohydrates and contains free sugars and starch (Wahditiya, 2016). sweet corn imports increased 42.46% from 517.5 thousand tons in the previous year to 737.2 thousand tons (BPS, 2021 in Amelia and Sugiharto, 2022).  This high demand is not matched by availability. Efforts to meet this demand include improving cultivation techniques such as used of superior varieties and ecological management. The combination of organic and anorganic fertilizers can play an important role because it can maintain soil health, productivity and plant fertility. The combination of goat fertilizer and KNO3 is expected to increase vegetative and generative performance. The research method used RAKF. The first factor is the dose of goat manure, K1 = 5 tons/ha, K2 = 10 tons/ha, K3 = 15 tons/ha. The second factor is the application of white KNO3 fertilizer P1 = 50 kg/ha, P2 = 100 kg/ha, P3 = 150 kg/ha. There were 9 treatment combinations and repeated 3 times and 5 samples. The observed parameters include: Plant height, number of leaves, leaf area, and flowering age. Data obtained from the observations of each variable were subjected to the F test with the method of variance (ANOVA). If the treatment combination accepted H1 then the comparison test will be done BNT 5%. The results showed that there was no interaction between the application of goat manure and KNO3 on the growth and yield. The application of KNO3  has a significant effect on the vegetative period of the plant number of leaves, plant height, stem diameter, and early flowering age of the plant.
RESEARCH STATUS OF INNOVATION AND ENTREPRENEURSHIP EDUCATION ECOSYSTEM: DATA ANALYSIS FROM CNKI IN CHINA
Authors: Li Chuanwei , Ab Rahman Anis Amira , Wang Tingting , Bahari Norzalizah
Published: July 2024

Innovation and entrepreneurship education ecosystem is a hot and difficult issue in the field of innovation and entrepreneurship education research in recent years. The research on innovation and entrepreneurship education ecosystem in China has gone through 10 years of research and development. In order to grasp the current status, hotspots, trends and future of innovation and entrepreneurship education ecosystem research in China, 158 sample documents from the CNKI database were taken as the research object, and the bibliometric method was used to visualise and analyse the big data of the literature in terms of the amount of papers published annually, the research topics, the distribution of disciplines, the high-yield authors, the journals of the published papers, the institutions of the published papers, the high citations, the number of downloads, and the categories of the sources. Comparison. The results found that: China's innovation and entrepreneurship education ecosystem research is mainly divided into the disciplines of higher education and vocational education; journals such as Innovation and Entrepreneurship Theory, Research and Practice, Journal of Heilongjiang Institute of Education and Modernisation of Education are the main dissemination carriers; PKUC is the main source of journals for high-quality theses; Huangshan College, Wenzhou University, Northeast Normal University and Henan University of Technology are the main publication institutions ; Jiangsu Provincial Fund Project and Ministry of Education Fund Project are the main funding funds.
A NOVEL HYBRID HOLT INTEGRATED MOVING AVERAGE (HIMA) FOR CONSUMER PRICE INDEX PREDICTION
Authors: Mohamad Fozi Nurin Qistina , Abdul Aziz Azlan
Published: July 2024

Holt's method, although successful, has limitations like its limited use for linear trends, seasonal fluctuations, and tendency to overestimate. The Damped Trend Method (DTM) was introduced to address these shortcomings, but still struggles with optimal forecast accuracy. Hence, this study proposes a new hybrid model by integrating the classical Holt's method and the Moving Average Box-Jenkins Methodology known as Holt Integrated Moving Average (HIMA). To evaluate the performance of the new hybrid model, Malaysia Consumer Price Index data from the year 1960 to 2022 was used. The dataset is partitioned using Repeated Time-Series Cross-Validation (RTS-CV). This study has also shown that the HIMA model has improved the forecasting of classical Holt's method and the Damped Trend Method (DTM) for time-series data, which has level and trend components. The results of this study show that HIMA has produced the lowest error measure value (1.5703, 1.1811, and 1.0013 for RMSE, MAE, and MAPE, respectively) and a high percentage of forecast accuracy (99 per cent) compared to other comparative models for CPI forecasting.
THE INFLUENCE OF ORGANISATIONAL INTEGRITY CULTURE ON ETHICAL PERFORMANCE IN PRIVATE HEALTHCARE: A STUDY
Authors: Harun Noor Haslina , Ahmad Fauziah Sh.
Published: July 2024

This study thoroughly investigates the vital role of organisational integrity culture (OIC) in Malaysia's private healthcare sector, highlighting the complex interplay between employee integrity performance (EIP) and the resulting competitive advantage derived from effective integrity practices. By combining resource-based and ethical theories into OIC, the research emphasises its strategic importance as a fundamental asset driving competitive advantage by cultivating integrity practice and boosting EIP. The study aims to analyse model fit and quantify significant construct correlations. Research inquiries, objectives, and hypotheses focus on understanding the influence of OIC on integrity practice, the impact of integrity practice on EIP, and the mediating role of integrity practice in the OIC-EIP relationship. SmartPLS provides methodological rigour in study design, target population delineation, sample, and reasoning. The study also seeks to fill gaps in private healthcare ethics literature and better understand how OIC affects staff ethics. Through empirical investigation, the study pioneers the exploration of the relationship between OIC and EIP in Malaysia's private healthcare sector, utilising the Malaysian Institute Integrity Index to illuminate this association. Ultimately, the researcher expects the findings to provide actionable insights for improving EIP through effective integrity practices while highlighting the critical role of organisational resources in sustaining competitive advantage.
EVALUATION OF CLASSIFICATION ALGORITHMS WITH SOLUTION TO CLASS IMBALANCE PROBLEM ON ZAKAT DISTRIBUTION DATASET
Authors: Wan Shahidan Wan Nurshazelin , Mohamad Nor Nor Azriani , Abdul Aziz Azlan , Ismail Nurul Fazira , Shafii Nor Hayati
Published: July 2024

Class imbalance is one of the most serious and significant issues in data mining classification studies. In recent years, there has been a lot of interest in the problem of imbalance in various real-world applications, such as fraud detection, medical diagnosis, and bank marketing datasets. Similarly, the Zakat distribution UiTM Perlis dataset was utilized to assess the imbalance in the dataset classes. The study aims to evaluate the performance of the resampling technique, Synthetic Minority Over-sampling Technique (SMOTE), and to identify the best classifiers for class-imbalanced Zakat datasets by comparing the classifier's performance. A resampling-based approach is proposed in this study to solve the imbalance dataset. This approach aims to enhance the true positive or the detection of the minority class, which in this case is the not eligible class. The evaluation is based on various metrics, which include accuracy, precision, recall, F-measure, and the ROC area. The algorithms considered in the study include Logistic Regression, Decision Tree (C.4.5), and Random Forest. The results indicate that Random Forest consistently performs well across all evaluation metrics after implementing SMOTE. It attains the highest accuracy, precision, recall, F-measure, and ROC area levels. In conclusion, this research highlights the effectiveness of SMOTE in resolving class imbalance in the Zakat distributions dataset. The evaluation of various classification algorithms will be conducted using WEKA.
INVESTIGATING GENDER DISPARITIES IN EMOTIONAL RESPONSES TO ONLINE LEARNING ENVIRONMENTS: IMPLICATIONS FOR EDUCATIONAL EQUITY
Authors: Shaziayani Wan Nur , Sarimah Sharifah , Norsyiha Fuziatul , Samsudin Norshuhada
Published: July 2024

This study explores the relationship between gender and emotional experience among undergraduate students enrolled in online distance learning (ODL) at UiTM Permatang Pauh, Penang. Understanding the emotional effect of transitioning to online distance learning, particularly amidst the COVID-19 pandemic, is crucial. Data analysis included correlation analysis to examine the relationship between gender and emotional experiences, as well as independent sample t-tests to compare emotional responses between male and female students. A total of 69 students participated, including 36 men and 33 women. The correlation analysis revealed significant gender disparities in emotional experience: male students reported higher levels of enjoyment (r = 0.831, p < 0.01) and hope (r = 0.408, p < 0.05), whereas female students reported lower levels of anxiety (r = -0.389, p < 0.05) and boredom (r = -0.671, p < 0.01). Independent sample t-tests confirmed these disparities in enjoyment, hope, anxiety, and boredom (all p < 0.05). These findings highlight the importance of considering gender-specific emotional responses to enhance inclusivity and optimise learning outcomes in diverse educational settings.
EFFECTS OF DHIKR SPIRITUAL MEDITATION PRACTICE ON THE RECOVERY OF DRUG ABUSER: A PHENOMENOLOGY STUDY
Authors: Kadri Rozeeda
Published: July 2024

Meditation based intervention such as mindfulness-based therapy, mantra, yoga, Qi Gong and Zen are generally focused on the integration of Buddhism, Hindhuism and Western psychology. However, little is known about Islamic dhikr spiritual meditation. The present article intent to describe the implications of dhikr meditation to recovering drug addicts’ wellbeing and life based on their experiences. Phenomenological qualitative study design was used with face to face and semi structured interview. Six participants were recruited among recovering drug addicts who had been in the Islamic rehabilitation centre and still practising dhikr spiritual meditation. The entire interviews were recorded and transcribed into verbatim. Then, the transcripts were thematic analytically. Four broad domains which spiritual changes, shift of thought, emotional and behavioural transformation were revealed after consistent and prolonged period of continuos dhikr spiritual meditation. Findings revealed that consistent practice of dhikr meditation has give an apparent impact on recovering drug addicts’ cognitive, emotion and behaviour. In conclusion, the individuals’ belief, values, culture, and spiritual paradigm should be addressed by healthcare professional and counselor to develop holistic strategy for drug addiction therapy.