bluuebunny/crossref_metadata_2025 huggingface dataset:
A high-resolution bovine mitochondrial co-expression network
Authors: Alexandre Pâmela A. , Keogh Kate , Reverter Antonio , Hudson Nicholas J.
Published: February 2025

The mitochondrion is a sophisticated, versatile, and dynamic organelle whose function is incompletely understood. Intending to provide a framework for mitochondrial visualisation and interpretation of genome-wide molecular data, we reverse-engineered a co-expression network whose final structure represented mRNA encoding more than half of the entire mitochondrial proteome. We drew upon 723 RNA-seq data sets representing 91 tissues and cell types from 441 individual cattle. A mitochondrial landscape was formed comprising a main network and many smaller sub-networks. One of the discrete sub-networks contains all 13 mRNA (e.g. MT-ND1, MT -CYTB, MT -COX2, MT -ATP8) plus 15/22 tRNA (e.g. MT-TT) encoded by the mt-genome itself, indicating some independent regulation from the nuclear genome with whom it must cooperate. Intriguingly, this mtDNA sub-network also contains a single nuclear-encoded gene, that of PDHA1. PDHA1 encodes a subunit of the pyruvate dehydrogenase complex that governs the conversion of pyruvate to Acetyl CoA. This enzyme is extremely influential, representing the fundamental cellular connection between the ancient, conserved pathway of glycolysis that occurs exclusively in the cytoplasm, and the TCA cycle that occurs within the mitochondrial matrix. To demonstrate the downstream utility of our approach, we overlaid Longissimus dorsi muscle transcriptome data from differentially feed efficient Charolais and Holstein Friesian cattle. This approach highlighted expression patterns sensitive to both breed and diet in a complex manner. An analytic advantage of this approach is that relatively subtle (<2-fold) but coordinated changes that may be overlooked by conventional gene-by-gene significance testing become readily apparent. Finally, intending to understand the transcriptional regulation of mitochondrial function more thoroughly, we engineered a network built with transcription factors in addition to those mRNA encoding mitochondrial proteins. Here, a set of influential nuclear hormone receptors (e.g. PPARA) are enriched among the most highly and/or well-connected TF.
Leisure Physical Activity, Sedentary Behavior, and Cardiovascular Health 2-7 Years after Pregnancy in the nuMoM2b HHS Cohort
Authors: Gibbs Bethany Barone , Modlin Sarah , Merz Noel Bairey , Haas David M. , Khan Sadiya S. , Lane Abbi , McNeil Rebecca B. , Varagic Jasmina , Huber Kimberly , Vasquez-Huot Ligia , Catov Janet M. ,   for the National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network
Published: February 2025

Purpose

To evaluate whether higher moderate-to-vigorous intensity physical activity (MVPA) and lower sedentary behavior (SB) are related to better cardiovascular health (CVH) following pregnancy.

Methods

In the nuMoM2b Heart Health Study (HHS) cohort, Life’s Essential 8 health factors (BMI, blood pressure, glucose, and lipid) were assessed in the first trimester of pregnancy and 2-7 years later (n = 3,985). The four health factors were scored with Life’s Essential 8 criteria (0 = poorest; 100 = ideal) and averaged to calculate a CVH health factor score (CVHhf
). Self-reported leisure MVPA and SB were assessed at follow-up. Linear regression evaluated associations of MVPA levels and SB quartiles with follow-up CVHhf after adjustment for first trimester CVHhf and covariates. Analyses were repeated after stratification by history of hypertensive disorders of pregnancy (HDP) or gestational diabetes (GDM).

Results

Over follow-up (mean 3.2 years after delivery), CVHhf declined from 85.6 to 81.6 points (-4.0 points, p < 0.001). The decline was greatest in lipid (-8.4 points, p < 0.001) and BMI scores (-5.6 points, p < 0.001). Healthier activity profiles (higher MVPA level and lower SB quartile) were each associated with higher CVHhf at follow-up: 0.7 points higher per level of MVPA, p < 0.001; 0.5 points lower per quartile of SB, p = 0.0042. Higher MVPA level associated with healthier BMI, glucose, and lipid scores; lower SB quartile associated with healthier BMI and blood pressure scores (p < 0.05). Although HDP/GDM history was associated with lower CVHhf, patterns of CVHhf across healthier leisure MVPA levels and SB quartiles were similar in those with and without HDP or GDM.

Conclusions

Higher MVPA and lower SB during leisure could help to maintain CVH health factors in the years following pregnancy, including among those who experienced HDP or GDM.
Ice Slurry Mitigates Hyperventilation and Cerebral Hypoperfusion, and May Enhance Endurance Performance in the Heat
Authors: Katagiri Akira , Kawai Syuntaro , Nishiyasu Takeshi , Fujii Naoto
Published: February 2025

Purpose

Hyperthermia causes hyperventilation and associated cerebral hypoperfusion, both of which may limit endurance performance in the heat. Here, we investigated the hypothesis that pre-exercise ice slurry ingestion may mitigate hyperventilation and cerebral hypoperfusion during exercise in the heat, enhancing endurance performance.

Methods

12 healthy men ingested 7.5 g/kg body weight of ice slurry (Ice) or the same solution at 37°C (Con) within 30 min. Thereafter, the participants performed cycle exercise for 30 min at 55% of peak oxygen uptake in the heat (35°C), followed by a cycle exercise at 90% of peak oxygen uptake until exhaustion.

Results

Esophageal, rectal, and gastrointestinal temperatures were lower throughout moderate-intensity exercise in the Ice than the Con trial (all P < 0.05). Correspondingly, minute ventilation was lower and cerebral blood flow index was higher in the Ice trial (both P ≤ 0.042, main effects of trial). Subjective severity of diarrhea and stomachache were increased in the Ice vs. Con trial (both P ≤ 0.041, main effects of trial). The duration of high-intensity exercise was not statistically different between the two trials (P = 0.160), though 8 out of the 10 participants exercised for a longer duration in the Ice trial, with a moderate effect size (r = 0.47). Based on z-scores and Grubbs' test, one outlier, who exhibited an extreme increase in ventilation and gastrointestinal complaints following ice slurry ingestion, showed a marked reduction in exercise duration.

Conclusions

Pre-exercise ice slurry ingestion alleviates hyperventilation and cerebral hypoperfusion during sub-maximal exercise in the heat and potentially improve subsequent high-intensity endurance performance, although the adverse effects associated with ice slurry ingestion might hinder the ergogenic effect in some individuals.
Body gesture recognition using crow search algorithm enhanced probabilistic neural network for human- computer interaction
Authors: V.S BAKKIALAKSHMI , Chawengsaksopark Pornpimol , Sathiyanarayanan Mithileysh
Published: February 2025

Background Body gesture recognition has become a fundamental technique in Human-Computer Interaction (HCI). As human-machine interaction evolves, there is an increasing need for precise and efficient gesture detection systems. However, current methods face limitations such as accuracy constraints, high computational complexity, and limited adaptability. This study addresses these challenges by proposing an innovative approach to enhance the accuracy and efficiency of body gesture recognition systems. Methods The proposed system integrates advanced algorithms and techniques to improve performance. A Marker-Based Watershed Algorithm is employed for accurate image segmentation, enhancing region detection. Feature extraction uses a Convolutional Neural Network (CNN), while a Wavelet Transform-Based Pre-Processing technique improves input data quality. A unique component of this method is the application of the Crow Search Algorithm to optimize model efficiency. An Optimized Probabilistic Neural Network (PNN) is utilized for gesture classification, aiming to increase precision and computational effectiveness. Results The proposed approach achieves a gesture recognition accuracy rate of 99%. Compared to traditional methods such as Decision Trees (DT), Support Vector Machines (SVM), and Improved Neural Networks (INN), the Optimized PNN demonstrates a 2.21% improvement in overall accuracy. The implementation, carried out in Python, showcases the robustness and adaptability of the system across diverse HCI applications. Conclusions This work presents a comprehensive solution to the challenges of body gesture recognition by integrating cutting-edge algorithms. Combining the Marker-Based Watershed Algorithm, CNN-based feature extraction, and Crow Search Optimization significantly enhances the system’s accuracy and efficiency. By addressing the shortcomings of existing methods, this approach provides a more responsive, reliable, and flexible gesture recognition system, contributing to the advancement of HCI technologies. The results demonstrate the potential for improved human-computer interaction through more effective and precise gesture detection.
Insights into climate variability of the meteorological records from a background monitoring station: the Giordan lighthouse, Gozo
Authors: Ciarlo` James , Vella Ryan , Saliba Martin , Ellul Raymond , Micallef Alfred , Coppola Erika , Micallef Aaron , Mifsud David
Published: February 2025

Background The Maltese islands are subject to significant climate variability, with implications for ecosystems and human activities. This study leverages a 26-year dataset from the Giordan Lighthouse Background Monitoring Station (GL) on the island of Gozo to analyse short-term climate variability and its alignment with broader regional trends. Methods Hourly meteorological data collected from 1997 to 2022, including wind speed, wind direction, air temperature, relative humidity, and air pressure, were analysed. The study examined diurnal and annual cycles, probability distribution functions, and climate indices to characterise local climate dynamics. Comparisons were made to existing findings based on the Malta International Airport dataset to validate results. Results The analysis revealed pronounced seasonal variability in all parameters. Rising air temperatures were detected, consistent with regional warming trends. Humidity and wind conditions showed seasonal shifts aligning with observations from other regional monitoring stations. The high-resolution dataset also captured fine-scale temporal patterns, reinforcing the critical value of localised, long-term meteorological monitoring for understanding climatic shifts. Conclusions This study underscores the value of long-term meteorological datasets in detecting climate variability and trends, including a clear warming pattern and seasonal shifts in temperature, humidity, and wind conditions. Continuous monitoring and improved data reliability are essential for enhancing climate assessments and supporting effective adaptation strategies in the Maltese Islands.
Coordinated U.S. Foreign Assistance and Effective Counterterrorism in Africa
Authors: Palacios Tammy
Published: February 2025

The international community can better partner with African countries and more effectively counter and prevent terrorism in Africa by implementing two changes to U.S. strategy. First, by crafting strategies that counter the kinetic and non-kinetic operations of al Qaeda and ISIS affiliated groups that allow for their territorial expansion and control. Second, by better coordinating U.S. foreign aid/development with security assistance and security cooperation efforts and conducting them with the partner country in a way that supports partner civilian and military institutions.
At current, U.S. security assistance efforts better connect to and strengthen the military/security apparatus than U.S. development assistance efforts do - this is due to risk averse bureaucracy that ultimately erodes democratic structures and processes rather than strengthening them. Additionally, U.S. tendencies to work directly with civil society organizations may not strengthen civil society pathways to ministries or the relevant offices at the district or national levels. U.S. and other international partners should work through and support a hub where local civil society and local level authorities can engage with and work with the district and national level governments. This strategy will strengthen good governance and democratic institutions.
Additionally, terrorism prevention and counterterrorism strategies that directly address and are formed in response to both active kinetic and non-kinetic operations of (al Qaeda and ISIS-affiliated) terrorist groups will better protect civilians as well as implementors of development and security assistance.
Review of the book “Capital Penetration and the Peasantry in Southern and Eastern Africa - Neoliberal Restructuring”
Authors: Veress Juhaszne Szilvia
Published: February 2025

"Capital Penetration and the Peasantry in Southern and Eastern Africa - Neoliberal Restructuring" is part of the Advances in African Economic, Social and Political Development book series to be published in 2022. The aim of this review is to present the contents of the book and to draw attention to the significance of the essays in the volume. It also aims to provide a brief recommendation for all those experts and researchers who are interested in the evolution, development and problems of agriculture and food security in sub-Saharan Africa.
Prace konserwatorskie, restauratorskie i przekształcenia fary Nowego Miasta Lubawskiego oraz jej wyposażenia i wystroju z l. 1921–1925 w świetle dokumentów
Authors: Binnebesel Wiktor
Published: February 2025

Autor dokonuje próby zarysowania problematyki związanej z pracami konserwatorskimi prowadzonymi w latach dwudziestych XX wieku w gotyckim kościele pw. św. Tomasza w Nowym Mieście Lubawskim. Podstawą opracowania jest jednostka znaleziona w Archiwum Państwowym w Bydgoszczy, w zespole Urząd Wojewódzki Pomorski w Toruniu (sygn. 6/4/0), zawierająca liczne dokumenty urzędowe i korespondencję dotyczące tego zagadnienia. W wyniku analizy zachowanych archiwaliów udało się szczegółowo poznać chronologię nieznanych dotychczas bliżej prac, ich koszty oraz czas realizacji. Do artykułu jest dołączony obszerny Aneks źródłowy – przytoczone we fragmentach dokumenty stanowią również interesujący przykład sposobu działania organów młodego państwa w sferze ochrony zabytków, a także ich problemów kompetencyjnych i prawnych.
Miejsca pozyskiwania aurypigmentu i realgaru w Europie, Afryce i na Bliskim Wschodzie od starożytności do początku XVII w.
Authors: Tarsińska-Petruk Dominika Anna
Published: February 2025

Aurypigment (As2S3) i realgar (As4S4) – żółty i czerwony siarczek arsenu – należą do najstarszej grupy pigmentów, które były stosowane przez malarzy od starożytności do XIX wieku. Ceniono je w Egipcie, na Bliskim i Dalekim Wschodzie oraz w Europie, gdzie największą popularność zyskały pomiędzy XII a XVII stuleciem. Pigmenty otrzymywano przez ucieranie naturalnych minerałów (aurypigmentu i realgaru) lub w wyniku reakcji chemicznych – prażenia i/lub sublimacji naturalnego aurypigmentu, arsenolitu z siarką i/lub naturalnym aurypigmentem oraz sublimacji siarki z trójtlenkiem arsenu. Aurypigmentu i realgaru używano na równi z cynobrem, malachitem, azurytem. Nakładano je pojedynczo lub łączono z organicznymi i mineralnymi substancjami barwnymi. W przyrodzie obydwa związki występują rzadko. Aurypigment i realgar mineralizują głównie w pobliżu gorących źródeł i fumaroli (czynnych wulkanów). W niniejszym artykule podjęto  próbę wstępnego usystematyzowania wiedzy na temat historycznych źródeł pozyskiwania obu minerałów. Omówiono miejsca ich wydobycia wymieniane w traktatach  historycznych od starożytności do XVII wieku, przeprowadzono weryfikację – na ile to było możliwe, na podstawie aktualnych badań geologicznych i archeologicznych –  aktywności kopalń w ujęciu chronologicznym: od Egiptu (złoża na Pustyni Arabskiej), przez Bliski Wschód (złoża na Wyżynie Irańskiej),  Półwysep Azji Mniejszej po Europę (złoża w Allchar w Republice Macedonii Północnej i Tajovie na Słowacji). Porównanie miejsc  wydobycia znanych z tekstów historycznych z wybranymi współczesnymi, prezentowanymi na portalach mineralogicznych, może okazać się pomocne w badaniach autentyczności i  proweniencji dzieł sztuki z różnych okresów historycznych.
Kazimierskie wozy wojenne w wyprawie z 1590 roku – itinerarium
Authors: Drzewiecki Bartosz , Stańczyk Sebastian
Published: February 2025

Temat wozów wysyłanych przez polskie miasta na potrzeby wojen w okresie wczesnonowożytnym jest dość dobrze rozpoznany. Historycy zajmowali się dotąd kwestiami ich wyposażenia a także mobilności. Jak dotąd nie zajmowano się jednak budżetami wypraw  tego typu jednostek bojowych. Zachowane źródła pozwalają z dużą szczegółowością odtworzyć podróż wozów wojennych z Kazimierza pod zagrożony przez Tatarów Lwów w 1590 r. W artykule dokonano rekonstrukcji trasy 54-dniowej wyprawy oraz jej kosztów dzień po dniu, z uwzględnieniem wynagrodzeń, napraw wozów oraz wyżywienia koni.
„Moje dziecie”. Relacja Teofili z Leszczyńskich Wiśniowieckiej (1680-1757) z Franciszką Urszulą w świetle korespondencji
Authors: Manyś Bernadetta
Published: February 2025

Prywatna korespondencja kobiet często ukazuje wielobarwny świat emocji między nadawcą, a odbiorcą (zwłaszcza między małżonkami, rodzicami a dziećmi). Stanowi ona potencjał do pisania historii życia prywatnego, codziennego czy rodzinnego. W tym kontekście szczególnie interesujący wydaje się być obraz relacji matka – córka i tego w jakim zakresie sfera prywatno-intymna dwóch kobiet, pełniących określone role w rodzinie staropolskiej, miała możliwość zaistnienia na kartach korespondencji.
Celem niniejszego artykułu będzie zatem próba ukazania relacji matka – córka na przykładzie informacji zawartych w listach (zgromadzonych w Archiwum Głównym Akt Dawnych w Warszawie) Teofili z Leszczyńskich p.v. Konarzewskiej s.v. Wiśniowieckiej słanych do córki Franciszki Urszuli Radziwiłłowej oraz jej małżonka Michała Kazimierza Radziwiłła zw. „Rybeńko” w pierwszych latach ich wspólnego pożycia.
Sprawozdanie z XI Międzynarodowego Kongresu Azjatyckiego w Toruniu (23 – 24 V 2024).
Authors: Sińczak Tomasz
Published: February 2025

Sprawozdanie z XI Międzynarodowego Kongresu Azjatyckiego w Toruniu.
The potential impact of glycine supplementation on the process of aging
Authors: Wójcikiewicz Michalina , Kulbacka Julia , Czyż Witold , Kacperczyk Julia , Dziedzic Karol , Chuncia-Ileczko Marta , Wojszczyk Maciej , Zys Damian , Pasek Piotr , Ryniecka Julia , Czaja Wiktor , Krzciuk Michał
Published: February 2025

Aging is a multifactorial process characterized by the progressive loss of cellular integrity, metabolic flexibility, mitochondrial function, and the gradual accumulation of oxidative and inflammatory damage. These changes increase vulnerability to age-related disorders, including cardiovascular disease, neurodegenerative conditions, metabolic syndrome, and frailty. Glycine, the simplest amino acid, has recently gained attention as a potential nutritional and therapeutic intervention to modulate various pathways implicated in aging. Beyond its structural role in collagen and other proteins, glycine is a critical precursor for glutathione- an essential intracellular antioxidant- plays a role in neurotransmission, and is involved in the synthesis of heme, creatine, and bile acids. Emerging studies suggest that glycine supplementation may alleviate oxidative stress, dampen chronic low-grade inflammation, improve insulin sensitivity, enhance mitochondrial function, and even mimic aspects of methionine restriction- a dietary approach known to extend lifespan in animal models. These combined effects may help preserve physiological function, slow the onset of age-associated diseases, and promote healthspan. Nevertheless, the evidence base is still evolving; most current data derive from animal models, in vitro experiments, and limited human trials. Rigorous, long-term, randomized controlled studies are needed to identify optimal dosing, determine long-term safety, and clarify whether glycine can be strategically leveraged as an anti-aging nutrient. If confirmed, glycine’s safety, affordability, and accessibility may make it a compelling option for improving the quality of aging worldwide.
Experimental study on Quality of Life and Overload in families caring for gifted children.
Authors: Barrera-Algarín Evaristo , Martínez-Fernández Rocío , Vallejo-Andrada Ana , Fernández-Reyes Teresa
Published: February 2025

The scientific literature and previous
research show that families of gifted
children tend to compensate for the
deficits in meeting the educational needs
of the group, making use of a multitude
of resources and extracurricular activities.
The objective of this study is to quantify
and measure the amount of these curricular
activities and their impact on the quality of
life of families of gifted children compared
to families of non-gifted children. The
methodology is a survey experiment
involving 160 families in Seville: 80 families
with gifted children (experimental group)
and 80 families with non-gifted children
(control group). The results show that
gifted children attend almost twice as
many extracurricular activities per week
as their non-gifted peers, and the cost to
their families is four times higher. This is
perceived by mothers of gifted children
as detrimental to their quality of life and
overburdens their free time, as measured
by the GENCAT and ZARIT scales.
Choose Your Battles Wisely: The Consequences of Protesting Government Procurement Contracts
Authors: Canayaz Mehmet I. , Cornaggia Jess , Cornaggia Kimberly
Published: February 2025

We examine the relationship between a firm’s successful protest of a government agency’s conduct or terms of a procurement contract and the amount of business the firm conducts with the government going forward. We find firms receive fewer and less valuable government contracts, face more contract cancellations, and experience significant reductions in sales growth and employee growth. Despite widespread belief, successful bid protesters do not delay government procurement because of lengthy dispute resolutions. Overall, we provide the first analysis of corporate interactions with the United States government bid protest system.

This paper was accepted by Tomasz Piskorski, finance.

Supplemental Material: The internet appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02055 .
Estado metabólico como predictor de enfermedad cardiovascular en una cohorte laboral: más allá del índice de masa corporal.
Authors: Bustamante-Rodríguez Juan Carlos , Zuzunaga Montoya Fiorella E. , Ballena-Caicedo Jhosmer , Valladolid-Sandoval Lupita Ana Maria , Vásquez Romero Luisa Erika Milagros , Loayza Castro Joan A. , Gutierrez De Carrillo Carmen Inés , Vera-Ponce Víctor Juan
Published: February 2025

Introducción: Las enfermedades cardiovasculares (ECV) son una causa principal de morbimortalidad global. Recientes investigaciones sugieren que el estado metabólico podría ser un mejor predictor del riesgo cardiovascular que el índice de masa corporal (IMC) por sí solo.
Objetivo: Evaluar los diferentes fenotipos metabólicos y el riesgo de desarrollar ECV en una cohorte de trabajadores.
Metodología: Estudio de cohorte observacional analítico retrospectivo con 4,158 trabajadores seguidos durante un máximo de 8 años. La variable respuesta fue la presencia de ECV, que se definió como la presencia del diagnóstico de accidente cerebro vascular o infarto por autorreporte. La combinación del estado metabólico y el IMC resultó en seis fenotipos: normopeso metabólicamente saludable (NMS), normopeso metabólicamente no saludable (NMNS), sobrepeso metabólicamente saludable (OBMSW), sobrepeso metabólicamente no saludable (OBMNSW), obesidad metabólicamente saludable (OBMS) y obesidad metabólicamente no saludable (OBMNS). Se calculó la incidencia de ECV y se utilizaron modelos de regresión de Cox para estimar los hazard ratios (HR) ajustados.
Resultados: La incidencia global de ECV fue de 5.64 por 1000 personas-año. Comparado con el fenotipo NMS, los fenotipos metabólicamente no saludables mostraron un riesgo significativamente mayor de ECV: NMNS (HRa: 5.19, IC 95%: 1.29-20.84), OBMNSW (HRa: 7.07, IC 95%: 2.40-20.86), y OBMNS (HRa: 7.35, IC 95%: 2.43-22.21).
Discusión: Los hallazgos subrayan la importancia del estado metabólico, independientemente del IMC, en el desarrollo del ECV. Esto tiene implicaciones significativas para la práctica clínica y la salud pública, sugiriendo la necesidad de implementar evaluaciones metabólicas comprehensivas y estrategias de prevención personalizadas en todas las categorías de IMC, especialmente en el ámbito laboral.
Ingesta de alimentos asociados a la desnutrición crónica en niños peruanos menores de 5 años con y sin lactancia materna.
Authors: Gomez Rutti Yuliana Yessy , Bernuy Osorio Nataly Dolores , Gordillo Cortaza Janet Del Rocio , Taboada García Marco Alexi , Acevedo Rique Isabel Margot , Vélez Pillco Eduardo Edison
Published: February 2025

Objetivo: Determinar la ingesta de alimentos asociados a la desnutrición crónica en niños peruanos menores de 5 años con y sin lactancia materna.
Material y métodos: El diseño de la investigación es no experimental, enfoque cuantitativo, observacional, descriptivo y transversal. La muestra fue de 12183 niños menores de 5 años, siendo el estudio un análisis secundario de la base de datos de la Encuesta Nacional Demográfica y Salud Familiar del 2022. Se utilizó el modelo estadístico de regresión logística binaria.
Resultados: Los niños sin lactancia materna no consumen agua (p=0,001, OR=1,269), jugo de fruta (p=0,001, OR=1,256), cualquier comida hecha de cereales (p=0,015, OR=1,279), Carne de res, hígado, otras vísceras (p=0,008, OR=1,209), Carne de pollo, pescado, mariscos, mondongo, otras carnes (p=0,009, OR=1,206) y vegetales de hoja verde oscuro (p=0,029, OR=1,156), existe más riesgo de padecer desnutrición crónica; además los que no consumieron bebidas gaseosas y caldo (p=0,011, OR=0,850) tienen menos riesgo de presentar desnutrición crónica. Los niños amantados que no ingieren té o café (p=0,013, OR=0,860) y las papillas de los programas sociales (p=0,028, OR=0,612) presentan menor riesgo de desnutrición crónica.
Conclusiones: Los niños sin lactancia materna que no consumieron bebidas gaseosas y caldo tienen menos riesgo de presentar desnutrición crónica, sin embargo, los niños con lactancia materna que no ingieren té o café y las papillas de los programas sociales del gobierno peruano presentan menor riesgo de desnutrición crónica.
The effect of nutritional assistance “gammarana program” on food acceptance and nutritional status of children in South Sulawesi, Indonesia
Authors: Nadimin Nadimin , Sirajuddin Sirajuddin , Afifah Sella Nur , Hadju Veny , Bohari Bohari
Published: February 2025

Background: Nutritional deficiencies are a public health issue requiring serious attention in Indonesia. This study evaluates the impact of the Gammarana Program on infant and child feeding practices and nutritional status in South Sulawesi. The program includes nutritional education and counseling provided by Village Nutrition Assistants (TPGD) in stunting-prone villages. The study aimed to assess the program’s effectiveness in improving feeding frequency, dietary diversity, food acceptance, and overall nutritional status of children.
Methods: A pretest-posttest design without a control group was used, involving 114 stunting-prone villages and 2,148 families. Over six months, TPGD provided education and counseling on infant and child feeding, growth monitoring, and supplementary feeding. Data were collected through interviews and anthropometric measurements and analyzed using McNemar’s test to determine changes before and after the intervention, with significance set at p<0.05.
Results: Results showed a 12.1% increase in feeding frequency, a 27.1% increase in dietary diversity, and a 25.3% improvement in food acceptance. The proportion of underweight children decreased by 1.2%, stunted children by 5.4%, and underweight children by 2.6%. Significant improvements were observed in feeding frequency, dietary diversity, and stunting reduction. Additionally, the increase in average nutritional Z-scores indicated an overall improvement in children's nutritional status.
Conclusion: The Gammarana Program effectively improved feeding practices and reduced stunting rates in South Sulawesi.
Utilizing applications Nutrihas Pro for calculated fluid and electrolyte requirements for patient.
Authors: Rogahang Christine , TASLIM Nurpudji A , SYAUKI Yasmin A , BUKHARI Agussalim , AMINUDDIN Aminuddin , ASHARI Nur
Published: February 2025

Background: Hospital malnutrition is a critical issue, particularly in regions like Makassar, Indonesia, where malnutrition rates surpass national averages. Malnourished patients often experience electrolyte imbalances and prolonged hospital stays, leading to increased healthcare costs. Despite the importance of accurate nutritional therapy, manual calculations are time-consuming and prone to human error, necessitating a more efficient solution.
Objective: This study aims to assess the effectiveness of the Nutrihas-Pro application, developed to improve the accuracy and time efficiency of nutritional therapy planning compared to manual methods.
Methods: An experimental repeated measures design was employed, involving 30 clinical nutrition residents at RSUP Dr. Wahidin Sudirohusodo. Participants manually calculated nutritional therapy and fluid/electrolyte needs for 60 patients and repeated the process using Nutrihas-Pro. Calculation times and accuracy were compared using paired-samples t-tests and chi- square tests.
Results: The Nutrihas-Pro application significantly reduced calculation times (p = 0.000) compared to manual methods, without compromising the accuracy of fluid and electrolyte requirement calculations (p > 0.05). Patients displayed a high prevalence of electrolyte imbalance (68.3%), particularly hyponatremia (35%).
Conclusion: Nutrihas-Pro improves time efficiency while maintaining calculation accuracy, making it a promising tool for nutritional therapy management. Further research is needed to address its limitations, including its reliance on internet connectivity and comparisons with other clinical calculator applications.
The relationship between water intake and the progression of urine albumin-creatinine ratio in patients with chronic kidney disease: A cohort-prospective study.
Authors: Yanti Mulyanti Sulastri , RASYID Haerani , AMINUDDIN Aminuddin , AS'AD Suryani , ASTUTI DAUD Nurpudji , AINUN RANI Nur
Published: February 2025

Introduction: The urine albumin-creatinine ratio (uACR) is a key biomarker for assessing kidney function in patients with chronic kidney disease (CKD), with elevated levels indicating kidney damage. Water and protein metabolism significantly impact kidney function. Proper hydration influences vasopressin feedback and osmolality regulation, while excessive protein intake exacerbates kidney stress through hyperfiltration and increased urea production. This study aims to investigate the relationship between daily water and protein intake and uACR levels in CKD patients.
Methods: A cohort study was conducted on 10 non-dialysis CKD patients at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Demographic and clinical data were collected, and average daily water and protein intake were assessed. The Spearman correlation test was used to analyze the relationship between water and protein intake and changes in uACR, albumin, and creatinine levels.
Results: A strong negative correlation was found between daily water intake and uACR (ρ=-0.891, p=0.001), indicating that higher water consumption reduces uACR. Conversely, protein intake showed a strong positive correlation with uACR (ρ=0.770, p=0.009) and urine albumin levels (ρ=0.806, p=0.005), suggesting that higher protein consumption increases both uACR and albumin excretion. No significant correlation was found between water or protein intake and urine creatinine levels.
Conclusion: This study highlights the importance of hydration and dietary protein regulation in managing CKD progression. Increased water intake may reduce uACR, while excessive protein intake can exacerbate kidney damage, emphasizing the need for dietary management in CKD patients.
Red guava (Psidium guajava L) juice increases hemoglobin levels in female adolescent.
Authors: Tirtawati Gusti Ayu , Kusmiyati Kusmiyati , Rompas Meivy , Terok Maria , Runtu Lorrien Grace , Fione Vega Roosa , Adam Yulien , Solang Sesca Diana
Published: February 2025

Background: One nutritional issue Indonesian adolescents face is micronutrient deficiency, with approximately 12% of male adolescents and 23% of female adolescents experiencing anemia, predominantly due to iron deficiency. Anemia in adolescent girls is particularly concerning as they are future mothers who will conceive and give birth, thereby increasing the risk of maternal mortality, preterm birth, and low birth weight. An initial survey of 7 female students revealed that 4 were anemic. This study aims to determine the effect of red guava juice on hemoglobin levels in female adolescents at a junior high school of SMP N 2 Belang, Belang District.
Methods: This quasi-experimental study employed a pretest-posttest with control group design, involving a total sampling of 30 respondents divided into 15 respondents in the treatment group and 15 in the control group. Data were collected through observation sheets and analyzed using paired sample t-tests.
Results: The paired sample t-test results indicated a significant effect of red guava juice on increasing hemoglobin levels in female adolescents, with a p-value of 0.002 and a mean value of 11.46 during the pretest and 12.58 during the posttest in the treatment group. In contrast, the control group, which did not receive any treatment, had a p-value of 0.334, indicating no significant increase in hemoglobin levels during the posttest. After consuming red guava juice, there was a considerable change from anemia to non-anemia.
Conclusion: Adolescent girls consume red guava juice as an alternative to increasing haemoglobin levels.
Acolhimento a criança autista e família na atenção básica de saúde
Authors: Alves de Miranda Camila , Bepler Rangel Samanta , Da Silva Teixeira Pereira Nelita Cristina
Published: February 2025

Autismo é um transtorno de desenvolvimento que compromete as habilidades de comunicação e interação social do indivíduo e colabora para certa regressão e, em alguns casos, em até perda de habilidades linguísticas, existem outras que se destacam como os cinco sentidos excessivamente sensíveis ou diminuídos, alteração emocional anormal com mudança de rotina, movimentos corporais repetitivos e apego anormal de objetos. Espera-se que os profissionais que lidam diretamente com essa clientela estejam preparados para o atendimento de nportadores do espectro autista e seus familiares/cuidadores. Esse estudo tem como objetivo identificar as dificuldades encontradas por profissionais de enfermagem no atendimento a crianças portadoras do autismo na comunidade. Trata-se de uma revisão integrativa, de caráter qualitativo, a pesquisa foi realizada com buscas em sites de pesquisa científica, tais como SciELO – Scientific Electronic Library Online, LILACS – Literatura Latino – Americana do Caribe em Ciências da Saúde e BVS – Biblioteca Virtual em Saúde, tem como critérios de inclusão, artigos científicos publicados entre os anos de 2008 à 2016 publicados em português com texto completo disponível online, foram utilizados como critério de exclusão artigos incompletos, em língua estrangeira, que não tinha relação com o tema. Após a leitura dos artigos, os mesmos foram agrupados por similaridade de conteúdo, formando duas categorias, a saber: acolhimento à família do portador de espetro autista e cuidados de enfermagem. Concluiu –se que a enfermagem carece de conhecimento sobre o transtorno do espectro autista, que falta conhecer mais o transtorno para poder prestar o acolhimento com qualidade às crianças e seus familiares em unidades básicas de saúde.
Preservação dos acervos em museus de Ciências: o caso do Museu Nacional e um olhar sobre a exposição Arqueologia do Resgate
Authors: Souza Peterli dos Santos Rute , Ribeiro Da-Silva Elidiomar
Published: February 2025

O presente trabalho busca evidenciar, por meio de um questionário, o conhecimento popular sobre as precárias condições em museus no Brasil. Usando a metodologia de análise qualitativa dos dados proposto por Bardin, surgem algumas reflexões desenvolvidas no decorrer do estudo. O trabalho usa o caso do incêndio no Museu Nacional/UFRJ e a exposição Arqueologia do Resgate: Museu Nacional Vive para levantar a questão da situação presente nos museus. Muitos acreditam no museu como local de ensino e educação, refletindo pensamento crítico e atuante sobre a segurança em museus de ciências, e ressaltam que perdemos cultura, arte, ciência e a credibilidade com a trágica ocorrência.
Natural substrates and amphipods epibionts contaminated by microplastic
Authors: Sorrentino Rayane , Resende de Senna André
Published: February 2025

Amphipods inhabit microhabitats that protect them against predation, provide nutrition and an area for reproduction and development. However, the compounds of the ecosystem are impacted by the presence of microplastics (MPs), which are a threat to marine communities. Since the organisms interact with and ingest/filter the different quantities of MPs, and may make it available to the associated epibionts, three natural substrates (algae, sponges, and ascidians) were sampled to compare the number of MPs in them and in their associated amphipods. This study was conducted on rocky shores from Rio de Janeiro (Brazil), differently from other studies that have been focused on experimental tests. The samples were submitted to density separation to extract the microplastics and acid degradation to access MP in amphipods. Algae retained a greater concentration of MPs as a sink of particles, as well as its associated amphipods. Sponges and ascidians have different mechanisms to filter water, which influences the MPs accumulation in amphipods. Those associated with sponges and ascidians had fewer microplastic particles. This is the first study comparing the retention of MP in different natural substrates and their amphipod epibionts, which gives information about microplastic contamination in these microhabitats and their associated organisms.
Capa e corpo editorial
Authors: Figueiró Ronaldo
Published: February 2025

Capa e corpo editorial
A reciclagem e a gestão dos resíduos sólidos urbanos: uma análise das interações com o ensino
Authors: De Oliveira Bastos Robson , Jácome Gurgel Junior Francisco , Agapito de Souza Ronildo Francisco , Barbosa Vargas André
Published: February 2025

A reciclagem e a gestão dos resíduos sólidos urbanos constituem em uma demanda importante atualmente e são essenciais para na redução do impacto na natureza. Implementada na temática da Educação Ambiental esta abordagem tem sido realizada de modo multidisciplinar e seus objetivos visam conscientizar o cidadão. Neste sentido, o objetivo deste estudo foi analisar as interações da reciclagem e a gestão dos resíduos sólidos urbanos com o ensino e as contribuições na formação de uma consciência ambiental. Para isso uma revisão da literatura foi realizada, utilizando artigos publicados nos últimos cinco anos. Os resultados mostram que o engajamento e a conscientização de todas as esferas da sociedade, além da atuação do Poder Público no processo de implantação de programas de gestão de resíduos sólidos foram os assuntos mais abordados. Além disso, pode se inferir que no ensino as abordagens apresentam observações às questões locais, mais precisamente o entendimento da população quanto a importância da coleta e tratamento dos resíduos sólidos, aproximando os estudantes de sua realidade local e regional.
Modernidade líquida e padrão corporal
Authors: Miranda Brum De Sousa Maria Cláudia , Lima Giviziez Marília , Paraíso Alves Marcelo
Published: February 2025

A presente pesquisa tem como centralidade a articulação entre a mídia, o padrão de beleza imposto pelo mercado e as redes sociais, visto que, o mercado estabelece determinantes que afetam as pessoas em seu cotidiano. Nesta linha de pensamento, o objetivo do trabalho é investigar como as redes sociais investem na produção de corpos que atendam o padrão estético da mídia e indústria cultural. O presente estudo se desenvolveu por intermédio da Revisão Integrativa da Literatura. Foi utilizada como base de dados o Google Acadêmico, tendo como recorte temporal os últimos 5 anos. Como caráter inclusivo foi determinado que apenas os artigos publicados em português iriam compor os dados da pesquisa. Os descritores utilizados foram: corpo e redes sociais; corpo e Instagram. Conclui-se que as redes sociais se configuram como o maior espaço de produção e consumo de corpos idealizados no contexto atual da sociedade, principalmente se considerarmos o Instagram.
Medicamentos fitoterápicos e aplicação veterinária em âmbito nacional
Authors: Silva Vidal Camila , Angeli Renata , Pimentel Victório Cristiane
Published: February 2025

As plantas medicinais e seus derivados dispõe de inúmeras propriedades terapêuticas, são empregadas na prevenção e tratamento de enfermidades de humanos e animais. O mercado de saúde veterinária vem ganhando notoriedade devido ao crescente número de doenças entre os animais, a elevada demanda por animais de companhia e a observância da segurança alimentar. A busca de tratamentos à base de plantas é consequência das adversidades dos tratamentos convencionais como antibióticos. No entanto, o uso de plantas na medicina veterinária é modesto, mesmo o Brasil sendo o segundo país com a maior população de animais de estimação do mundo e sua considerável participação na produção de animais. Entre os fitomedicamentos e fitoterápicos é relevante a aplicação de produtos dermatológicos, de infecções parasitárias, distúrbios gastrointestinais e do sistema nervoso. Os antiparasitários são os mais abundantes entre os produtos registrados. A empresa Winner Horse, Multiboi Nutrição Animal e Provets Simões Lab. tem o maior número de registros de fitomedicamentos de uso veterinário. É necessário um maior investimento em fitomedicamentos para uso veterinário, visto o significativo potencial terapêutico, e se apresentam como uma solução para alguns problemas resultantes do uso indiscriminado e contínuo de fármacos convencionais.
GAP JUNCTION: Emphasis on Connexin 43
Authors: Oliveira Alves Moreira de Carvalho Gabriella , De Jesus Souza Olga Maria , Da Silva de Azevedo Fortes Fabio
Published: February 2025

The junctions of the cell are complex structures that play a fundamental role in cellular communication. They are morphologically distinct and are divided into occlusion junctions, adherens junctions and gap junctions. This review has the objective of providing the main information about the gap junctions demonstrating its components and highlighting their role in cellular maintenance, emphasizing the studies of junctions, formed by connexin 43 (Cx43), which is widely found in various tissues, highlighting its function in the main systems, the formation cycle and possible interactions. For this, we searched the databases: CAPES, Scielo, Scopus, Science Direct and PubMed using keywords and selecting the articles with the inclusion and exclusion criteria to structure a document for students and researchers of the areas of cellular biology, biophysics and physiology.
Escherichia coli uropatogênica carreadora de blaCTX-M de pacientes ambulatoriais no Rio de Janeiro
Authors: Bauer Canellas Anna Luiza , De Freitas Oliveira Maria Clara , Da Silva Oliveira Alves Gabrielle , Rezende Vieira de Mendonça e Souza Cláudia , Pavoni Gomes Chagas Thiago , Gomes do Rosario Gabriel , M. Rocha Souza Claudio , D’Alincourt Carvalho-Assef Ana Paula , Da Silva Laport Marinella , Piffano Costa Pellegrino Flávia Lúcia
Published: February 2025

Escherichia coli uropatogênica (UPEC) é o patógeno Gram-negativo mais isolado como causa de infecção no trato urinário (ITU). Cepas de UPEC resistentes aos antimicrobianos têm sido detectadas no mundo todo. O elevado número de prescrições de antibióticos para tratar a ITU, incluindo antimicrobianos da classe dos beta-lactaâmicos, está diretamente associado ao aumento das taxas de resistência de uropatógenos aos antimicrobianos e à disseminação de genes de resistência. Em Escherichia coli, a produção de enzimas beta-lactamases de espectro estendido, conhecidas como ESBLs constitui o principal mecanismo de resistência a antimicrobianos da classe dos beta-lactâmicos, sendo a ESBL do grupo CTX-M a mais prevalente entre amostras de UPEC isoladas no Rio de Janeiro. O objetivo do presente estudo, portanto, foi investigar a presença de genes que codificam ESBLs do tipo CTX-M em cinquenta e três amostras de UPEC recuperadas de pacientes diagnosticados com ITU, atendidos no ambulatório de um hospital público da região metropolitana do Rio de Janeiro, entre maio e junho de 2019. As amostras foram identificadas por MALDI-TOF MS. A presença dos genes blaCTX-M-1,2; blaCTX-M-8 e blaCTX-M-14, foi investigada através da reação em cadeia da polimerase (PCR). Todas as amostras foram identificadas e confirmadas como Escherichia coli. Um total de 12 amostras (23%) foram positivas para os genes blaCTX-M-1,2 mas os genes blaCTX-M-8 e blaCTX-M-14 não foram detectados entre as amostras do estudo. Este achado corrobora com dados da literatura que mostram que CTX-M é a ESBL prevalente em UPEC no Rio de Janeiro e evidencia a crescente dificuldade encontrada pelos clínicos para tratar casos de ITU por UPEC, devido à resistência antimicrobiana.
Uso de modelos animais com alto potencial de degradação de biomassa lignocelulósica para produção de etanol de segunda geração
Authors: Bertholdo Irapoan , Suhett Albert Luiz
Published: February 2025

O uso de biomassa lignocelulósica para produção de etanol de segunda geração vem sendo amplamente estudado, visto que existe uma necessidade de se desenvolver combustíveis que usem matéria prima de fontes renováveis. Uma das barreiras encontradas é o elevado custo de enzimas que hidrolisam essa biomassa. Uma forma de baratear este custo é buscar em modelos animais enzimas com alto potencial de degradação dos resíduos lignocelulósicos. Neste trabalho foi efetuado o levantamento do uso de modelos animais (cupim, caramujo e barata), com potencial de degradação de biomassa lignocelulósica para produção de etanol. Para realização do estudo foi feita uma pesquisa bibliográfica, recorrendo a base bibliográfica digital Web of Science. Dos 89 artigos analisados, vinte e oito estudaram a atividade das celulases, quarenta e quatro os processos de digestão/degradação de celulose, treze a expressão de genes que codificam celulases e quatro trataram dos processos de alimentação. Os artigos analisados demonstram que cupim, caramujo e barata são modelos animais com alto potencial de degradação de biomassa lignocelulósica para produção de etanol de segunda geração. O modelo mais estudado nos últimos 68 anos foi o cupim, com estudos abordando em sua maioria os processos de degradação/digestão da celulose e atividades das celulases.