bluuebunny/crossref_metadata_2025 huggingface dataset:
Legal Representation of Patients with Dementia in Long Term Care Settings
Authors: Camilleri Lara
Published: April 2024

Introduction: Dementia is a neurodegenerative disease which affects cognitive, physical, and behavioural abilities. To date there is no effective disease-modifying treatment, so the course of disease is progressive [1]. Worsening cognition in advanced stages can impair the person’s mental capacity to make decisions. Consequently, advanced care planning (ACP) is an important aspect in dementia management [2]. Guardianship is an integral part of ACP where the patient legally appoints a trusted person to make best interest decisions for them should they lose capacity. As a result, this study aims to assess the legal representation of patients suffering from dementia. Method: Patients residing in all the nine dementia wards at Saint Vincent De Paul Residence (SVPR), were recruited (203 patients). A diagnosis of dementia is a requirement for admission to these wards. A data collection sheet was designed and included data on the patient’s demographics, MMSE scores and guardianship statuses. Data was collected retrospectively from the patient’s medical records and their caring medical team where documentation was lacking. The data collection period included September to October 2022. Results: Only 7 patients had a guardianship present (3%). The patients’ children (57.1%) were more likely to apply for guardianship, followed by the patients’ spouses (28.6%). The guardianship status was clearly documented in the doctors’ notes and next of kin (NOK) paper, together with the name and contact details of the guardians. 196 patients (97%) did not have guardianship. 5 of these had a power of attorney (POA) but the type was not specified. 190 patients had a relative or friend listed as the next of kin (NOK) and a patient had no legal guardian or NOK. Conclusion: Most patients with Dementia did not have formal legal representation like guardianship or valid POAs. However, the majority of NOK documented were in line with the legal definition of the responsible carer according to the MHA
Parhyangan Universitas Pendidikan Ganesha, Buleleng, Bali (Sejarah, Struktur, Fungsi dan Potensinya Sebagai Sumber Belajar Sejarah di SMA)
Authors: Luh Ayu Martasari  , Mudana I Wayan , Purnawati Desak Made Oka
Published: April 2024

Penelitian ini bertujuan untuk mengetahui: (1) sejarah berdirinya Parhyangan Universitas Pendidikan Ganesha di Buleleng, Bali, (2) struktur dan fungsi Parhyangan Universitas Pendidikan Ganesha, Buleleng, Bali dan (3) potensi Parhyangan Universitas Pendidikan Ganesha sebagai sumber belajar sejarah di SMA. Metode penelitian yang digunakan yakni metode penelitian sejarah yang terdiri dari : Heuristik, Kritik sumber atau verifikasi, Interpretasi, dan Historiografi. Hasil penelitian menunjukan bahwa: Parhyangan Universitas  Pendidikan Ganesha (Undiksha) di Kampus Pusat mulai dibangun pada tahun 2003 dan diresmikan pada tanggal 2 Juni 2004 yang dulunya masih bernama IKIP Singaraja. Adapun struktur Parhyangan menggunakan konsep Tri Mandala, pada area Utama Mandala terdapat pelinggih Ratu Taksu, Padmasana, Pelinggih Ganesha, Panglurah Agung, Linggih Bhatara Tirta dan Bale Piasan. Pada area Madya Mandala terdapat Pelinggih Kiwe Tengen, Bale Gong, Bale Pewaregan dan Penanda Peresmian dan di area Nista Mandala terdapat Wantilan, Sulang Aing (Lebuh) dan Toilet. Parhyangan juga memiliki empat fungsi yakni Fungsi Religius sebagai tempat persembahyangan, Fungsi Sosial sebagai tempat pemersatuan umat Hindu, Fungsi Budaya sebagai tempat pementasan kesenian dan pengembangan ketrampilan diri baik itu seni suara, seni tari dan seni tabuh, dan  Fungsi Pendidikan sebagai tempat belajar non formal dalam bidang keagamaan. Selain itu, potensi Parhyangan Universitas Pendidikan Ganesha (Undiksha) di Kampus Pusat sebagai sumber belajar dapat dikembangkan pada aspek spiritual, aspek pengetahuan, aspek sosial dan aspek budaya.

Kata Kunci: Parhyangan, Sejarah, Struktur, Fungsi, Sumber Belajar
Nilai-Nilai Toleransi Pada Perayaan Maulid Nabi Di Desa Tegallinggah, Sukasada, Buleleng Bali Dan Potensinya Sebagai Sumber Belajar Sejarah
Authors: Muhari Rahman  , Tuty Maryati  , I Wayan Pardi
Published: April 2024

This study aims to find out that: (1) the Celebration of the Prophet Muhammad's Birthday inTegallinggah Village (2) the uniqueness of the Prophet Muhammad's Birthday Celebration inTegallinggah Village (3) The values contained in the Prophet Muhammad's Birthday whichcan be used as a source of learning History. The method used in this research is to use adescriptive qualitative research method. This descriptive qualitative research methodemphasizes a quality of research. There are 3 steps used in this descriptive qualitative research,namely observation, interview and document study. The results of the study show that thebirthday of the Prophet Muhammad was introduced for the first time by the Fatimid dynastylong before Al-Barjanzi was born who is known as the maker of poems praising the ProphetMuhammad. However, the Prophet Muhammad's birthday was really popular during the timeof the governor of Ibril (Iraq), namely Abu Sa'id Al-kukburi during the reign of SultanSalahudin Al-ayyubi. After the leadership of Sultan Salahudin Al-ayyubi, the celebration ofthe Prophet's Birthday eventually spread throughout the world, including Indonesia. Theculture that was brought to Indonesia eventually mixed with the local culture so that theelements at Maulid also contained elements or mixing with local culture. The values that canbe used as a source of historical learning are religious values, social values and cultural values.These three values will later be wrapped in the Historical Social Studies Module.Keywords: History of Mawlid, Culture, Historical Teaching Resources
Acute Cholangitis GRADE II–III. The View of an Interventional Radiologist
Authors: Okhotnikov O. I. , Yakovleva M. V. , Shevchenko N. I. , Grigoriev S. N. , Okhotnikov O. O.
Published: April 2024

Aim of study To evaluate the safety and efficacy of percutaneous transhepatic cholangiostomy (PTC) as a first-line intervention in the treatment of patients with acute cholangitis (AC) Grade II–III (TG 13/18).

Material and methods The results of treatment of 42 patients with AC Grade II–III, who underwent PTC, were analyzed. The criteria for non-inclusion were the presence in patients of destructive cholecystitis and (or) acute pancreatitis, AC due to proximal block of the bile ducts, regardless of etiology, as well as the presence of cholangiogenic liver abscesses. Literature data were used as reference results of the use of endoscopic techniques. AC was diagnosed and its severity was determined in accordance with the diagnostic criteria TG 13/18. The control points of the study were the frequency of post-manipulation complications associated with PTC, as well as the immediate efficacy of cholangiostomy, assessed by the dynamics of Grade-status within 24 and 48 hours.

Results In all 42 patients, PTC was technically successful. Major complications that might require a change in treatment tactics (significant hemobilia, bile peritonitis, bleeding into the abdominal cavity) were not observed. Two complications occurred: subcapsular hematoma (2.4%) and right-sided pleurisy (2.4%). When assessing the dynamics of Grade status, its significant decrease was found in the group of patients with initial Grade III after 24 hours (from 16 to 9 hours) and 48 hours (from 9 to 4 hours). In patients with initial Grade II status, in three cases it worsened to Grade III, which still persisted in one patient even in 48 hours. There was no in-hospital mortality in the examined patients.

Conclusion Antegrade endobiliary intervention for acute cholangitis involves performing real-time monitored biliary decompression. Experience with the use of percutaneous interventions does not confirm the high risk and frequency of post-manipulation complications in comparison with endoscopic retrogradeprocedures. It seems obvious that there is a need for and the possibility of choosing both retrograde and antegrade methods of emergency biliary decompression in the arsenal of treatment for patients with acute cholangitis.
Distal Bypass Surgery for Critical Ischemia Using a Related Donor Vein
Authors: Karpov V. V. , Kalinin R. E. , Suchkov I. A. , Egorov A. A. , Zaitsev O. V. , Pshennikov А. S. , Karpov D. V.
Published: April 2024

The article presents a case of using the trunk of the great saphenous vein from a living related donor in elective surgery for the main arteries of the lower leg. The possibility of using a vein from a relative in special clinical situations is shown. High risks of repeated interventions aimed at relieving early and late complications of vascular reconstructions remain an urgent problem in angiosurgery. Very often, operations are performed in the presence of extensive necrosis and trophic ulcers (stage IV according to the Fontaine-Pokrovsky classification). The gold standard for choosing a shunt during reconstructive operations on the infrainguinal arteries was and remains an autovenous conduit from the great saphenous vein (C, D type of arterial bed lesion according to TASC II). During repeated reconstructions in the absence of a suitable autovein and with the distal position of the peripheral anastomosis, it is not always possible to use a synthetic prosthesis as a reliable alternative. Unsatisfactory Results of using such materials dictate the need to choose a suitable graft. The problem of using allografts requires further in-depth study. In this regard, the case of using a donor vein as a material for reconstruction is given. It was concluded that it is possible to effectively use allovein from a related donor in a patient after previously performed reconstructive interventions and in the absence of autologous material for bypass surgery.
Double Postbulbar Block in the Prevention of Postmanipulation Pancreatitis
Authors: Frolov P. A. , Korotkevich A. G.
Published: April 2024

Abstract The problems of preventing postmanipulation pancreatitis (PMP) remain the subject of debate and a lot of research from leading scientific clinics around the world. The article is devoted to the assessment of prevention methods of PMP in patients with lesion of the pancreaticobiliary zone who underwent transpapillary interventions. Aim of the study Evaluation of the effectiveness of the author’s method of preventing PMP.

Material and methods A prospective two-center randomized study included 545 patients treated in the Department of Liver Surgery and General Surgery in 2020–2022, who underwent ERCP and endoscopic papillosphincterotomy. There were 146 (26.8%) male patients, and 399 (73.2%) female patients, aged from 18 to 92 years, the mean age 62.7±7.4 years. Patients were divided into 3 groups according to the method of preventing PMP: in the 1st group, standard drug premedication was supplemented with two postbulbar blocks with a solution of lidocaine 0.5% 10 ml before and after the intervention (RF Patent No. 2779221, 09/05/2022), in the 2nd group standard premedication was combined with placebo was used, and in the comparison group 3 no submucosal injections were performed. The monitoring of clinical manifestations of PMP and the level of amylase was carried out every 12 hours until the parameters normalized. Statistical processing was carried out using program STATISTICA 6.1 for Windows.

Results The frequency of mild pancreatitis, corresponding to the criteria for PMP, did not exceed 18% in groups 1 and 3 (p=0.3408), but was lower with pseudo postbulbar block, 9% (χ2=2.83, р=0.0926), the difference was not statistically significant. The incidence of severe pancreatitis was significantly lower in group 1 with double postbulbar block where there were no cases of pancreatic necrosis among 143 patients (χ2=6.19, р=0.0129). The mortality did not differ significantly among groups (χ2=0.15, р=0.7004). The duration of the hospital period had significant differences between groups (Student’s t-test 1.973, p=0.001). The hospital period with double postbulbar block turned out to be significantly shorter.

Conclusion 1. Double postbulbar blockade significantly reduces the risk of developing severe postmanipulation pancreatitis, regardless of existing risk factors. 2. Double postbulbar block significantly reduces the duration of the hospital period after endoscopic papillosphincterotomy. 3. Pseudo postbulbar block using saline requires further evaluation as a possible way to prevent mild pancreatitis.
Instrumental Tracheal Rupture
Authors: Khachatryan S. A. , Chernousov F. A. , Danielyan Sh. N.
Published: April 2024

Abstract Tracheal rupture is an urgent life-threatening complication that relates to complex and poorly understood areas of trauma surgery. The article presents a review of modern world and domestic literature on instrumental tracheal ruptures, the Relevance of early diagnosis and various treatment methods. Based on an analysis of modern literature data, the article describes the issues of conservative and surgical treatment methods, as well as an assessment of their results. The problem of the diagnostic algorithm and the choice of conservative, surgical treatment has not been solved and remains relevant. The issues of treating patients with a defect in the membranous wall of the trachea in intensive care and in need of artificial ventilation in clinical practice remain unresolved. All of the above indicates the Relevance of the study.

Aim of the study To present data from domestic and foreign literature on the diagnosis and treatment of instrumental tracheal ruptures.

Material and methods A review of the literature was carried out for the period from 1993 to 2024 in Russian and English, available on the databases Pubmed, Medline, UpTodate, Scopus, E-library, on topics such as post-intubation tracheal rupture, iatrogenic tracheal rupture, diagnosis and treatment of instrumental tracheal ruptures, closed tracheal injury.

Results The concept of the classification system, risk factors, etiopathogenesis is outlined. Information is provided on the diagnostic significance of computed tomography and tracheobronchoscopy. Close attention is paid to the methods and choice of treatment tactics, the principles of intraoperative tactics, and the strategy of conservative treatment. A comparative assessment of treatment Results and their complications with a conservative or surgical treatment approach is given.

Conclusion Thus, an analysis of domestic and foreign literature indicates that the issues of diagnosis and treatment of iatrogenic tracheal injuries remain largely unresolved. There is no generally accepted algorithm for instrumental diagnosis of tracheal ruptures. There are no uniform approaches to determining indications and contraindications for conservative and surgical treatment of tracheal injuries. There are diametrically opposed opinions regarding the choice of treatment tactics. These contradictions create significant difficulties in assessing the Results of treatment of this complex category of patients.
PENYADAPAN DALAM TINDAK PIDANA TERORISME DI INDONESIA DAN FILIPINA DITINJAU DARI PERSPEKTIF HAK ASASI MANUSIA
Authors: - Shinta Dewi Kumalasari
Published: April 2024

Terrorism in Indonesia and the Philippines is growing rapidly. Wiretapping is used as a method of investigating terrorists. The purpose of this study is to find out and examine whether wiretapping of terrorism suspects according to the terrorism law is with human rights and the reasons why wiretapping terrorism in Indonesia takes a longer period of time than in the Philippines. Normative research method with statutory approach and comparative law. Sources of data in the form of secondary data consisting of primary legal materials and secondary legal materials. Wiretapping has not been specifically regulated in the law, while in practice it has caused controversy over the wiretapping procedure. Wiretapping is a problem because it violates the privacy rights of citizens. Wiretapping must be carried out in line with human rights principles including technical and licensing so that it can prove that wiretapping is certainly intended to provide protection. Wiretapping in Indonesia takes longer because terrorism networks in Indonesia are not centered on one area, so it takes a relatively long time to conduct wiretapping.
REVIEWING THE CONSTITUTIONAL RIGHTS ON DEMOCRATIC ELECTION PRACTICES IN INDONESIA AND THE PHILIPPINES
Authors: Dachi Janvencius Valerius Nifowa'azaro , Shahrullah Rina Shahriyani , Syarief Elza
Published: April 2024

One form of democracy's embodiment is through general elections. The Philippines and Indonesia are two countries in the Southeast Asian region that are currently still developing their democratic practices through general elections. This study aims to compare how the general elections have been enforced in the two countries to obtain input on the implementation of democracy in Indonesia. The normative legal research design was used in this study, and data collection was carried out through a literature study. The functional comparative approach compares the implementation of general elections in the two countries. The data collected by literature searches were analyzed using a qualitative juridical analysis method. The analysis shows that although the two countries have declared themselves democracies and the general election is the form of their implementation in the constitution, general elections have been used to perpetuate power in both countries. The two countries have differences in implementing general elections due to historical differences and national problems. The most distinguishing matter that can be learned is how the Philippines implemented the general election through the existence of a plebiscite that makes the people more involved in the state process. In addition, information technology in the Philippines' general election has also made the process of conducting the general elections effective and efficient. This study is still limited to analyzing general elections at the national level, especially the presidential and vice-presidential elections. Further research on the general elections of legislature members and regional heads can add to our understanding of the comparative implementation of the two countries.
PENGUATAN NORMA SYARAT DISPENSASI KAWIN DALAM UPAYA PENCEGAHAN PERKAWINAN ANAK BERDASARKAN PERSPEKTIF TEORI TUJUAN HUKUM
Authors: Sulistyarini
Published: April 2024

Marriage dispensation is a form of exception to marriages performed below the minimum age limit stipulated by law, which is 19 years. This arrangement results in the stipulation of the minimum age limit for marriage being deviated, exacerbated by the ambiguity of the norms of requirements in the application for a marriage dispensation, resulting in applications for a marriage dispensation that are often granted without being based on urgent reasons that show the urgency of the implementation of marriage for children who have not reached the age limit for marriage. This paper will examine strengthening the norms of marriage dispensation requirements as an effort to prevent child marriage by using the theory of legal purposes. This research is a normative legal research using statutory and case approaches. The results of this research conclude that the normative requirements contained in the provisions of Article 7 Paragraph (2) of Law Number 16 of 2019 concerning Amendments to Law Number 1 of 1974 concerning Marriage are not accompanied by clear boundaries as standardization for judges in deciding requests for dispensation married for various reasons, resulting in judges interpreting the meaning of the article broadly so that the granting of a marriage dispensation request is highly dependent on the subjectivity of judges. This reduces the spirit of preventing child marriage and does not manifest the values ​​of justice, benefit, and legal certainty.
PROGNOSTIC VALUE OF THE TRIGLYCERIDE-GLUCOSE INDEX IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA AND THEIR OVERLAP
Authors: Halytska V.O. , Stupnytska H.Ya.
Published: April 2024

Considering that patients with concurrent COPD and asthma frequently have metabolic disorders, special attention should be given to their detection and subsequent correction, as their presence triggers mechanisms of mutual exacerbation, and their progression worsens the prognosis.The goal is to study the correlation between the triglyceride-glucose index, bioimpedance analysis parameters, and spirometry in patients with chronic obstructive pulmonary disease, asthma, asthma-COPD overlap, and comorbid type 2 diabetes.Materials and methods. 25 patients with COPD, 23 with asthma, 25 with asthma-COPD overlap (ACO), and 33 patients with ACO and diabetes mellitus type 2 were examined. The average age of patients was 57[52;67] in the COPD cohort, 52[50;65] for asthma, 51[43;52] for asthma-COPD overlap (ACO), and 60[53.5;65] for ACO with diabetes mellitus type 2. The parameters of external respiration were determined using the BTL 08 SpiroPRO spirometer (UK), bioimpedance analysis was carried out using the portable TANITA BC-601 device (Japan). The level of triglycerides (mmol/L) was determined by the colorimetric method, and fasting glucose was determined by the glucose oxidase method. The triglyceride-glucose index was calculated using the formula: TyG index = ln [fasting TG (mg/dL) x fasting glucose (mg/dL) / 2].Results. The following correlations were established: BMI and FEV1/FVC before bronchodilation (r = 0.23, p = 0.02) and SVC (r = -0.24, p = 0.01); % fat and FVC before bronchodilation (r = -0.23, p = 0.01), as well as SVC (r = -0.21, p = 0.03); visceral fat levels with FEV1 before and after bronchodilation (r = -0.36, p < 0.001 and r = -0.35, p < 0.001) and FVC before and after bronchodilation (r = -0.32, p < 0.001 and r = -0.30, p < 0.001) and SVC (r = -0.33, p < 0.001); TyG and FEV1 before and after the bronchodilation test (r = -0.25, p = 0.01 and r = -0.28, p = 0.005), as well as FVC only after the use of bronchodilator (r = -0.25, p = 0.02).Conclusions. The bioimpedance analysis and TyG index correlate with pulmonary function test parameters (FEV1, FVC, FEV1/FVC ratio, SVC, MVV) in examined patients with COPD, asthma, ACO, and the combination of ACO and type 2 diabetes. Further research prospects. Further studies are needed to clarify the possibility of using the TyG index in clinical practice not only as an alternative indicator of insulin resistance but also as a marker of deteriorating lung function in case of airflow obstruction.
FEATURES OF THE MANAGEMENT OF PATIENTS WITH POSTPARTUM PURULENT-SEPTIC COMPLICATIONS
Authors: Pasternak B.O. , Lisova K.M.
Published: April 2024

Postpartum purulent-septic diseases are one of the topical issues of modern obstetrics due to their high prevalence and absence of a downward trend toward reduction in the disease incidence.Aim. Іmprove the management of high risk puerperas to prevent the development of purulent-septic complications in the postpartum period.Material and methods. The cohort prospective comparative study included 78 puerperas who experienced spontaneous labour complicated by injuries to birth canals. The patients were divided into two groups according to the risk of developing purulent-septic complications and the management of patients. Group 1, (n = 20) included the puerperas who did not show any signs of inflammatory diseases of the genital tract during pregnancy. Group 2 included patients, who were diagnosed with various forms of vaginal dysbiosis based on the results of bacterioscopic and bacteriological examination of the genital tract. The group was further divided into two subgroups depending on the type of treatment. Subgroup 1 of Group 2 (n = 28) only received standard hygiene care, and Subgroup 2 (n = 30) received standard hygiene procedures combined with vaginal irrigation using chlorhexidin solution for 3 days in the obstetric hospital.Research results. The study resulted in improving postpartum care of high-risk puerperas to prevent purulent-septic complications.Discussion. The test results showed that the use of chlorhexidin in the postpartum period prevents the purulent-septic complications of puerperium, such as inflammation and disruption of perineal muscle sutures and endometritis, as well as relieves pain and discomfort, and improves the puerperas’ quality of life.Conclusion. Based on the study results, we recommend the use of this drug in the early postpartum period to prevent purulentseptic complications in the high-risk groups.
DIGITALIZATION OF THE ELECTROCARDIOGRAM IN THE OPTIMIZATION OF THE TREATMENT OF ACUTE AND CHRONIC CORONARY SYNDROMES WITH THE USE OF RANOLAZINE
Authors: Tashchuk V.K. , Malinevska-Biliichuk O.V.
Published: April 2024

Aim – to evaluate the effectiveness of ranolazine in optimizing the treatment of acute and chronic coronary syndromes, using the capabilities of a differentiated electrocardiogram.Material and methods. 135 patients were involved in the study: 45 patients with ST-segment elevation myocardial infarction (STEMI) and 90 patients with stable angina pectoris (SA), functional class II-III. Depending on the treatment received, patients with STEMI were divided into group I, with inclusion in basic therapy of ranolazine (Pn), which consisted of 30 people, and control group II, which included 15 patients who received only basic therapy (K). People with SA were divided into three groups depending on the drugs included in the complex therapy (antiplatelet agents, statins and nitrates): group A - 30 patients additionally took lercanidipine and enalapril as part of the "polypill" drug (LE), group B - 30 people who received lercanidipine and enalapril as part of the "polypill" drug and ranolazine (LE+Rn), group V - 30 participants who took ramipril and ranolazine (Pm+Pn). The duration of treatment was 30 days. All patients were interviewed according to the EQ-5D-5L questionnaire with the EQ-VAS visual analog scale, carried out echocardiography and electrocardiogram (ECG) with digitalization of its indicators using the "Smart-ECG" medical software.Results. In patients with STEMI in group I (Rn) we noted increasing in quality of life (40.00 (30.00; 50.00), Δ +100.00%, p<0.001), left ventricular ejection fraction (LVEF) (50.50 (44.50; 55.00) %, Δ +6.93% (р<0.001) and the ratio of maximal speed (MSR) in the ischemic zone (0.64 (0.55; 0.71), Δ +76.56%, p<0.001). The frequency of increasing of MSR in the ischemic zone was significantly higher when ranolazine was included in the basic treatment (OR=7.000; 95% CI: 1.167; 42.001, p=0.020). An increase in the quality of life and a decrease in MSR in lead V2 (marker lead to assess LV hypertrophy) were observed in all groups of SA (in all cases p<0.05). In group B (LE+Rn), the greatest increase in LVEF was recorded (57.00 (55.25; 60.75) %, Δ +8.77 %, p<0.001). An increase of MSR in the ischemic zone was observed in group B (LE+Pn) (1.02 (0.62; 1.18), Δ +17.65%, p<0.001) and in group V (Pm+Pn) (0.86 (0.57; 1.05), Δ +12.79%, p<0.001). Conclusions. The addition of ranolazine in the treatment of STEMI and SA contributed to the improvement of the quality of life, the optimization of the contractile capacity of the myocardium due to the increase of LVEF, the increase of MSR indicator of the differentiated ECG in the ischemic zone, which confirmed the reduction of the electrical instability of the ischemic myocardium.
INFLUENCE OF ANDROGEN STATUS ON THE RISK OF HOSPITALIZATION FOR CARDIOVASCULAR DISEASES IN MEN WITH CORONARY HEART DISEASE
Authors: Khaniukov O.O. , Bucharskyi O.V.
Published: April 2024

Aim – to create a mathematical model for predicting the risk of hospitalizations within 6 months in men with coronary artery disease (CAD), taking into account androgen status and other clinical and laboratory parameters.Materials and methods. 102 men aged 45-65 with a diagnosis of coronary artery disease were included in the study. Key predictors were identified using ROC analysis, including testosterone level, age, cholesterol, systolic blood pressure, and heart rate. These parameters were integrated into a logistic regression equation to formulate a predictive model for the risk of hospitalization during the next 6 months. The results. The logistic regression model demonstrated reliable predictive capabilities with an area under the ROC curve of 0.790, p<0.05. The coefficients of individual parameters revealed a significant contribution to the overall forecasting accuracy. The obtained formula allows us to estimate the probability of hospitalization during the next six months for men with coronary artery disease.Conclusions: This study created a predictive model for the risk of hospitalization in men with CAD, providing clinicians with a tool for risk assessment and management. Taking androgen status into account along with traditional cardiovascular risk factors increases the accuracy of the received prognosis. The obtained results emphasize the potential of personalized medicine in optimizing patient care. Prospects for further research: Future research should focus on external validation of the developed model in different populations and the study of additional factors that may improve risk prediction. In addition, the study of dynamic changes in the predicted parameters over time can improve the temporal accuracy of the model.
POLAND SYNDROME: A CASE REPORT
Authors: Protsailo M.D. , Slyusar N.Y. , Leontieva Y.A. , Dzhyvak V.H. , Kryckyy I.O. , Horishniy I.M.
Published: April 2024

Poland syndrome is a rare but serious condition that can affect a child's development and quality of life. Understanding the clinical features of this syndrome and the risk factors that can cause it is essential for timely diagnosis and treatment. However, there is currently a limited number of scientific studies on this pathological condition, so further research in this area is relevant and requires attention. The aim of the study was to review the literature, clinical features of Poland syndrome in a child and to analyse the risk factors that can lead to the onset of this condition.Results of the study. Premature placental abruption is a condition in which the placenta, an organ that forms during pregnancy to provide nutrition and oxygen to the fetus, detaches from the uterine wall before the onset of labour. It disrupts the balance between the forces of the uterine and fetal muscles, which can lead to thrombosis, bleeding and other complications for both mother and fetus. This condition can be observed in any trimester of pregnancy and requires the attention of doctors for timely diagnosis and treatment. Poland syndrome is a congenital anomaly characterised by chest and muscle defects, as well as other developmental defects. According to the Foucras classification, there are three or four degrees of severity, depending on the level of asymmetry and deformation of the chest. Hypoplasia of the chest muscles, cardiovascular anomalies, hand and finger abnormalities are among the complications that can accompany CP. A clinical study revealed severe chest asymmetry and motor disorders in a child diagnosed with Poland syndrome (incomplete form). The risk factors for premature placental abruption in the mother were a history of previous pregnancy complications and a viral urogenital infection.Conclusions. Studying the clinical features of Poland syndrome and the risk factors leading to its occurrence is important for the timely diagnosis and treatment of this condition in children. Understanding these aspects can help improve the quality of life of patients and prevent complications.
PECULIARITIES OF DYSURIA TREATMENT IN MEN WITH BENIGN PROSTATIC HYPERPLASIA
Authors: Zaitsev V.I. , Fedoruk O.S. , Iliuk I.I. , Vladychenko K.A.
Published: April 2024

Objective of the work is to analyze the practical aspects of medical treatment of urination disorders in men with benign prostatic hyperplasia (BPH). Results. Recently, more and more patients with BPH are being treated conservatively due to the increased availability of drug therapy. Traditional alpha-blockers (AB) do not always have a sufficient effect in reducing dysuria in such patients. In recent years, a number of new treatment options have been introduced into the Guidelines of the European Association of Urology (EAU) for the diagnosis and treatment of non-neurogenic voiding disorders - phosphodiesterase 5 inhibitors and beta-3 adrenomimetics have been added to cholinolytics (CL). These groups of drugs have different mechanisms of action, and some of the recommended drugs (such as CL) help relax the bladder wall and have traditionally been used in women with symptoms of overactive bladder (OAB). CL has been well studied in this category of patients both in terms of safety and efficacy. At the same time, when used in men with BPH, especially in the presence of benign prostatic obstruction (BPO), there remains the question of safety in terms of worsening urination. Although most current studies do not demonstrate an increased risk of acute urinary retention as a side effect, a number of recommendations should be followed for safe treatment of such patients. It is recommended to use CL in patients with severe and moderate urinary disorders with a predominance of irritative symptoms. However, the size of the prostate gland is not a criterion for the use of CL. Conducting urodynamic studies is also not recommended to determine the necessity or safety of one or another treatment option, they are reserved only for complicated cases or when neurogenic urination disorders are suspected. Conclusions. Complex urodynamic studies are not routinely used, while uroflowmetry should be used as a method of general evaluation of urination efficiency, diagnosis of BPO and effectiveness of patient treatment. Residual urine should be determined before taking the drugs (it is recommended that it not exceed 150 ml) and after a week of treatment.
LOCOMOTOR ACTIVITY OF RATS WITH BLAST-INDUCED TRAUMATIC BRAIN INJURY IN A COMPLEX MAZE
Authors: Kozlova Yu.V.
Published: April 2024

Aim – to investigate the peculiarities of rats with blast-induced brain injury movement in the complex maze.Material and methods. The study was carried out on 15 sexually mature Wistar rats. All animals were randomly divided into 3 groups: experimental group (n=5), which was anesthetized and exposed to an air shock wave with an overpressure of 26-36 kPa; sham group (n=5), which was only anesthetized, and intact group (n=5). The study of locomotor activity was performed using a complex maze for 5 consecutive days, starting on the 1st day after the simulation of blast-induced brain injury. The route of rat`s movement through the maze of three groups was graphically depicted and visually analyzed.Results of the study. The complex maze is considered to be complicated due to the presence of a central zone and T-shaped branches to the right and left, ending with feeders. The complication of the situation and task lead to fear with rapid adaptation of healthy rats. However, if the brain functions are impaired, the experimental animal loses its physiological ability to adapt and shows signs of anxiety. The analysis of the images of the movement paths showed that on the 1st day of training, the rats of the experimental group moved more actively, despite the fact that the animals did not yet know that food was waiting for them. They performed monotonous movements and went to the side sectors more often. On 2nd day, the experimental rats were more active and explored the maze more stereotypically than intact animals. On 3rd and 4th days, clear signs of spatial memory impairment in the experimental group were found in terms of lengthening the path to the feeder. On the 5th day, it was found that the experimental rats were still poorly oriented in the maze, with a monotonous examination of the side sectors.Conclusions. Thus, mild blast-induced traumatic brain injury leads to persistent impairment of spatial memory, as well as behavioral disorders in the form of anxiety. The rats of the experimental group demonstrated stereotypical locomotor activity, as evidenced by the examination of the lateral sectors of the complex maze. At the same time, the memory for food reinforcement was well developed and retained.
INTERPLAY OF METABOLIC DYSREGULATIONS, OBESITY, PATHOLOGIES OF ABDOMINAL ORGANS, RESPIRATORY ORGANS, CARDIOVASCULAR SYSTEM, AND CHRONIC KIDNEY DISORDERS AS POTENTIAL RISK FACTORS FOR MALIGNANT NEOPLASMS IN THE CONTEXT OF PALLIATIVE MEDICAL PRACTICE
Authors: Marchuk I.V.
Published: April 2024

Metabolic changes, obesity, diseases of the abdominal cavity organs, respiratory organs, cardiovascular system, and chronic kidney diseases are risk factors for the development of malignant neoplasms. This poses new challenges in palliative practice: the use of integrated methods, the study of new biomarkers, and the application of modern technologies, the formation of professional readiness of medical personnel for activities in the field of palliative and hospice care. Objective. The study aims to conduct an epidemiological analysis of the prevalence and comorbidity of malignant neoplasms among patients in northern Bukovyna and to analyze the relationship between metabolic changes, obesity, diseases of the abdominal cavity organs and respiratory organs, cardiovascular system, and chronic kidney diseases as risk factors for the development of malignant neoplasms in the context of palliative medical practice. Material and methods. Clinical data of patients, data on metabolic status and obesity, information on the condition of abdominal cavity organs, respiratory organs, cardiovascular system, and kidneys, results of diagnostic tests, as well as applied statistical methods for assessing the relationships between different factors and the risk of malignant neoplasms were utilized.Results. The obtained results indicate a significant impact of metabolic changes, obesity, and diseases of various organs on the increased risk of malignant neoplasms in patients undergoing palliative care. The identified correlations underscore the necessity of an integrated approach to treatment, focused on managing metabolic status and systemic diseases. The discussion complements this by highlighting potential interaction mechanisms and pointing out opportunities for improving palliative care through emphasis on prevention and management of these risk factors.Conclusion. The research highlights the importance of understanding and managing metabolic, organic, and systemic risk factors, as they are interdependent in palliative practice, pointing to potential opportunities for improving treatment outcomes and the quality of life for patients with malignant diseases.
Protokol mezhdisciplinarnogo vzaimodejstviya osteopata i stomatologa v processe ortodonticheskogo lecheniya
Authors: Аптекарь И. А. , Абрамова Е. В. , Постников М. А. , Копецкий И. С. , Еремин Д. А. , Постникова Е. М. , Полуянова Э. Б. , Аптекарь В. И. , Муравьев И. О.
Published: April 2024

Sovremennoe ortodonticheskoe lechenie nosit kompleksnyj harakter i vklyuchaet ne tol'ko ispol'zovanie s"emnyh i nes"emnyh ortodonticheskih konstrukcij, no i operativnoe lechenie (ekstrakciyu postoyannyh zubov) v slozhnyh sluchayah. Neobhodimy tshchatel'noe obsledovanie i podgotovka pacientov pered ortodonticheskim etapom lecheniya dlya profilaktiki otricatel'nyh rezul'tatov i oslozhneniij korrekcii zubochelyustnyh anomalij i deformacij, kak u detej, tak i u vzroslyh. Rezul'taty mnogih issledovanij ukazyvayut na vzaimosvyaz' mezhdu ortodonticheskim lecheniem i formirovaniem somaticheskih disfunkcij. Cel'yu raboty bylo razrabotat' algoritm korrekcii osteopaticheskih narushenij, kotoryj mozhet byt' vnedren v praktiku mezhdisciplinarnogo vzaimodejstviya vracha-osteopata i stomatologa-ortodonta dlya povysheniya kachestva specializirovannoj ortodonticheskoj medicinskoj pomoshchi.
Relato de caso clínico de tratamento de hiperpigmentação periorbital com hidroapatita de cálcio hiperdiluída
Authors: Tafner Ana Paula Martins Freitas , de Biasi Daniela Borges , Feitosa Pedro Carvalho , Oliani Sílvia Aparecida Gimenes Cantele , Miyahira Alexandre
Published: April 2024

As alterações na região infraorbital são um dos primeiros sinais de envelhecimento da face, e a hiperpigmentação desta região, popularmente denominada olheiras, se constitui em uma das principais queixas da HOF. A compreensão da anatomia, das alterações do envelhecimento e a determinação da etiopatogenia das olheiras são importantes para o correto diagnóstico e determinação do tratamento. A utilização de bioestimuladores de colágeno pode ser uma opção de tratamento para essa região. Os bioestimuladores possuem a capacidade de atuar nas regiões mais profundas da derme, estimulando a produção de colágeno através de respostas inflamatórias subclínicas localizadas. São materiais biocompatíveis, com biodegradação, apresentando eventos adversos mínimos e bons resultados. Atualmente, existem poucos estudos que comprovem a segurança do tratamento com os bioestimuladores de colágeno, a base de hidroxiapaptita de cálcio, hiperdiluído, utilizados na região infraorbital. O objetivo deste trabalho é relatar um caso clínico com a utilização de bioestimulador a base de hidroxiapatita de cálcio hiperdiluída, para tratamento da hiperpigmentação infraorbital. Os resultados encontrados foram a diminuição da hiperpigmentação infraorbital, melhora do sulco pálpebromalar, por melhora da sustentação e firmeza da pele, com um rejuvenescimento facial.
Reestruturação Glútea Multicamadas com Princípios Injetáveis Ortomoleculares
Authors: Loss Ricardo
Published: April 2024

Os tratamentos estéticos para melhoramento glúteo estão cada vez mais em alta nas clínicas de estética. Tratar um bumbum vai além de apenas melhorar a camada dérmica, e sim melhorar os grupos musculares do glúteo e realizar um equilíbrio intracelular de macro e micro nutrientes baseados nos princípios ortomoleculares. O objetivo do procedimento proposto foi de tratar duas camadas de tecido a fim de melhorar a flacidez tissular e musculas do paciente, proporcionando um aumento de volume como consequência. O tratamento proposto foi baseado em princípios injetá- veis ortomoleculares aplicados a nível muscular sistêmico e local e logo em seguida a realização da técnica Mixbooster canulado. Foi utilizado o kit injetável Gluteomax da PHD do Brasil, um produto desenvolvido pelo Instituto Ricardo Loss em parceria com esta empresa. O resultado foi satisfatório, melhorando flacidez muscular e tissular e ainda aumentado a perimetria do glúteo.
A importância do conhecimento do Melasma para o profissional da HOF: revisão atualizada
Authors: Galache Thaís Rodrigues , Galache Marcelo
Published: April 2024

Objetivo: Com a busca pela estética orofacial aumentando a cada dia, os profissionais da Harmonização Orofacial devem atualizar-se e entender a complexidade do Melasma, que acomete muitas mulheres, no qual levam a um grande abalo psicológico e um impacto negativo em suas vidas. Este estudo tem como objetivo analisar as características dessa afecção e tratamentos citados na literatura até os dias de hoje. Material e Métodos: Baseou-se em 61 referências bibliográ- ficas sobre as características do Melasma e seus tratamentos, embasados cientificamente, com a utilização de palavras-chaves como Melasma, melanogênese, estética facial. Contextualização: O Melasma é uma afecção até hoje incompreendida, mesmo com uma grande quantidade de estudos, é classificada como crônica e considerada ainda de etiologia indefinida. As pesquisas atuais levam a um entendimento sobre características clínicas da pele com Melasma, como eritemas com telangiectasias pronunciados no local da lesão da mancha, aumento da vascularização da derme, além de evidências histológicas da participação dos fibroblastos senescentes (FBS). Diante disso, os tratamentos atuais para a hipercromia atuam principalmente com intervenção em conjunto nas células da camada dérmica e epidérmica, além de tratamentos preventivos como a utilização de protetor solar e terapêuticas para o fotoenvelhecimento.
Assessment of Landslide Vulnerability in Urban Areas Using GIS and Remote Sensing: A Study in Ambon City
Authors: Lasaiba Mohammad Amin , Tetelepta Edward Gland , Ansiska Paisal
Published: April 2024

Slope stability and land movements, commonly referred to as landslides, are natural hazards that involve the shifting of materials like soil, rock, and debris, primarily caused by the force of gravity. This research utilized both qualitative and quantitative approaches, focusing on spatial analysis by examining primary and secondary data derived from satellite imagery, observations, and pertinent institutions. Processing of the collected data using specialized software like Global Mapper 20, ArcGIS 10.8.1, and ER Mapper 8.1. The findings of this investigation disclosed that a significant portion of Ambon City, roughly 51.63% of its area, exhibited high susceptibility to landslides. Conversely, only about 16.26% of the total area demonstrated very low or low vulnerability. Similar trends were observed in urbanized regions, where the majority, around 39.01%, were classified as highly vulnerable (Z-4). In contrast, approximately 35.09% showed very low vulnerability (Z-1), and 11.89% depicted low vulnerability (Z-2). The study's findings clearly highlight a critical situation in Ambon City, where a substantial 89% of its territory, characterized by mountainous landscapes, is experiencing a markedly increased frequency of landslides. Given these concerning insights, it is absolutely essential for government authorities to engage in rigorous spatial planning. This should involve redirecting development efforts towards areas identified as safer, away from high-risk zones. Furthermore, the government must enforce and adhere to policies that not only mitigate landslide risks but also promote sustainable development, ensuring the long-term safety and resilience of Ambon City against such natural disasters.Keywords: Mapping, Landslide, Vulnerability, Build Area
Generación pandémica: lazos personales, laborales y políticos en las nuevas juventudes
Authors: Ferro Ulises , Semán Pablo , Welschinger Nicolás
Published: April 2024

A partir de una investigación iniciada en mayo de 2020 y que se prolonga hasta la actualidad, en la que realizamos más de 150 entrevistas y 12 focus groups, relevamiento de redes sociales y medios de comunicación, nos interrogamos acerca de los efectos de las medidas sanitarias de cuidado para hacer frente a la pandemia en la experiencia de las juventudes actuales. En este artículo en particular, indagamos sobre los efectos en el plano de los lazos afectivos, laborales y en el vínculo en general con el Estado. Argumentamos que el período pandémico exacerbó procesos previos afectando de manera profunda y duradera esos tres planos llevando a lo que llamamos un “triple fracking pandémico” sobre la generación que atravesó su juventud marcada por los dos años de la pandemia.