bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between physical activity and subsequent changes in disease activity in people living with rheumatoid arthritis
Authors: Lee-Pii Kiera , Xie Hui , Zheng Yufei , Li Linda , Lacaille Diane
Published: April 2021

Various studies have demonstrated how rheumatoid arthritis (RA) patients perform less physical activity than the general population, likely due to joint pain and impaired physical function. However, physical activity (PA) may have beneficial effects on reducing inflammation and RA disease activity. The objective of this study was to evaluate the association between baseline PA levels and self-reported changes in measures of RA disease activity.

 

We conducted a longitudinal study using 2015-2017 data from an annual survey administered to an RA cohort in BC. Subjects were grouped into three levels (Low, Medium and High) of PA at the baseline year (2015) according to the specifications of the International Physical Activity Questionnaire. Subsequently, we examined whether baseline PA was associated with changes in RA disease activity outcomes over 2015 to 2017, using fitted linear mixed models for each measure and adjusting for age, sex and other covariates.

 

Of the 169 patients who responded to the 2015 survey, 29.6%, 42.0%, and 28.4% were grouped into Low, Medium, and High levels of PA, respectively. Our results demonstrated that the Low PA group experienced significant worsening of disease activity outcomes over the three years, including those of the Rheumatoid Arthritis Disease Activity Index (RADAI) (p=0.007), Fatigue (p=0.007), and Pain (p=0.007). Those in the Medium and High PA groups at baseline experienced either a decrease or no change in their disease activity outcomes over time. These results add to the accumulating evidence that physical activity may reduce disease activity and is essential to RA management.
The Celtic Otherworld in Patrick Rothfuss's Kingkiller Chronicle
Authors: MacDonald Cameron
Published: April 2021

As readers of fantasy literature, we look for clues in the stories we read, familiar landmarks whose shapes we unconsciously know. These landmarks ensure that, while the stories we read may be new to us, we know (or think we know) where it leads. One legend commonly adapted as a landmark for modern fantasy is the Otherworld, a parallel dimension of supernatural creatures that has featured in Celtic stories for thousands of years. It is a magical place that inspires both fear and wonder. Patrick Rothfuss adapts this legend for his Kingkiller Chronicle. He calls his version of the Otherworld the Fae Realm, and the supernatural creatures who inhabit it Fae Creatures. In this paper I attempt to show that Rothfuss’s strikingly Celtic Fae Realm functions as a unique sort of landmark; since stories of the Celtic Otherworld are multifarious and often contradictory, and encounters with the Otherworld and its people often have diverse impacts on heroes, its presence in the Kingkiller Chronicle acts as an unsettling force, raising questions about the capacity of the initially invincible Kvothe to overcome the effects of this unpredictable obstacle.
Oral feeding outcomes of infants with neonatal abstinence syndrome
Authors: Nagy Stephanie
Published: April 2021

The Government of Canada in 2016 officially declared the opioid crisis as a national public health emergency. 1As the opioid crisis continues to prevail, the number of expecting mother’s using opioids during their pregnancy is increasing, as well as complications associated with the infant’s health. Neonatal abstinence syndrome (NAS) occurs when the infant experiences withdrawal symptoms, such as hyperirritability, excessive crying and tremors after birth due to the in-utero drug exposure.  These withdrawal symptoms often interfere with infant’s ability to engage in oral feeds, and thus they receive their nutrients via tube feedings. 2 However, infants who are in the NICU must have achieve independent oral feeds before being discharged from the hospital. The concept of NAS infants having longer feeding times compared to other NICU infants has been a common assumption, but no research has sought out to quantitively prove this. This study will be conducted by a retrospective chart review and the participants will be infants with NAS who are in the NICU and require pharmacological interventions. This study group will be matched with a control group of infants, with respiratory distress syndrome, for birth age (1-week difference) and birth weight (≤500 g difference). Independent group t-tests will be conducted to determine if there is a statistically significant difference between the two groups in time to reach independent oral feeds and a Chi square test will be used to compare baseline demographics.

References

University of Wisconsin. (2015). Canada: Opioid consumption in morphine equivalence

(ME), mg per person. Retrieved from

http://www.painpolicy.wisc.edu/sites/www.painpolicy.wisc.edu/files/country_file

s/morphine_equivalence/canada_me_methadone.pdf

Velez, M., & Jansson, L.M. (2008). The opioid dependent mother and newborn dyad:

non-pharmacologic care. Journal of Addiction Medicine, 2(3), 113-120. DOI:

10.1097/ADM.0b013e31817e6105
Assessment of vitamin content in different types of romanian cheese
Authors:   University of Agronomical Sciences and Veterinary Medicine Bucharest, Romania, GHERGHINA EVELINA , ISRAEL-ROMING FLORENTINA , BĂLAN DANIELA , LUŢĂ GABRIELA , POPA AGLAIA , ZACHIA MARTA
Published: April 2021

In recent years there was a preference for healthy natural products hence an increased interest in functional food including fermented dairy products occurred. Dairy products contain nutrients essential for health, of which vitamins could help reduce the risk of certain diseases. Cheese is a highly nutritious food that can play an important role in a wellbalanced diet. The aim of this research was to investigate the vitamin composition of various types of cheese and to evaluate the vitamins intake provided by cheese as part of the daily diet. The determinations were performed on traditional Romanian cheese, meaning cow, sheep, goat and buffalo Telemea and some Kashkaval types purchased from local supermarkets. The samples were subjected to vitamins B1, B2, B12, A and E analysis using spectrofluorometric, spectrophotometric, HPLC and microbiological methods. The results showed a higher content of vitamins B2 and E in Telemea cheese while Kashkaval types were distinguished for vitamin B1, B12 and A. Regarding the vitamin content depending on raw material used for obtaining the different types of cheese, those made from goat milk recorded the highest level of the analyzed vitamins, followed by those from sheep milk, while lowest amounts were found in products obtained from cow.
Studies of Resistance to Sharka (Plum Pox) in Romanian Apricot Progenies
Authors:   University of Agronomic Sciences and Veterinary Medicine Bucharest, 59 Marasti, Romania, ION LIGIA , BOLOACĂ MIRELA OLGA ,   University of Agronomic Sciences and Veterinary Medicine Bucharest, 59 Marasti, Romania
Published: April 2021

Sharka (Plum pox) is considered one of the most devastating diseases of stone fruits in terms of agronomic impact and economic importance. The response of several apricot hybrids was evaluated over the vegetative period of 2010 by visual monitoring of symptom development and by serological and molecular methods. After two cycles of study, all the replicates of ‘Mari de Cenad’, ‘Traian’ and ‘Tabriz’ showed sharka symptoms while the replicates of ‘Stark Early Orange’ and NJA 2 did not show any symptoms and were not ELISA-positive. The resistant progenitors (‘Stark Early Orange’, NJA17, NJA42 and NJA2) were able to transmit PPV resistance to their descendants, in agreement with previous results (DOSBA et al, 1994, MARTINEZ-GOMEZ et al, 2000; AUDERGON et al, 1994). The genetic control hypotheses for PPV resistance in apricot referenced by different authors considered the resistance allele as dominant. Romanian apricot F1 and F2 progenies evaluated were classified into two groups: susceptible to PPV and resistant to PPV. After that the most important genotypes were grafted onto infected GF 305 (considered as indicator for PPV) in greenhouse conditions. The final step is the introduction and development of the marker-assisted selection (MAS) in PPV resistance F1 and F2 progenies in apricot Romanian genotypes. DNA was isolated from all hybrids and parent genotypes. These samples will be used to implement the molecular markers for identification of genes linked to plant response to PPV infection.
Antioxidant potential, Total Vitamin C, phenolic and flavonoids content of sweet potato leaves
Authors:   National Institute of Research and Development for Potato and Sugar Beet, 2 Fundăturii Street, 500470, Brasov, Romania, CIOLOCA MIHAELA , BĂDĂRĂU CARMEN LILIANA , TICAN ANDREEA , POPA MONICA
Published: April 2021

Sweet potato leaves are a valuable source of bioactive nutrients such chlorophyll, reducing sugars, dietary fibers, vitamins, minerals and phenolic compounds. The present study evaluated the vitamin C content, total phenolic and flavonoids contents in sampled mature leaves from five sweet potato genotypes (’Hayanmi’, ’KSP1’, ’KSC1’, ’Yulmi’, ’Juhwangmi’) grown in green house conditions. The highest values for all chemical compounds analysed were found in leaves sampled from ‘KSP1’ and ‘Yulmi’ cultivars. Positive significantly correlation between the antioxidant activity estimated by DPPH radical scavenging activity and vitamin C content (r2 = 0.892), total polyphenol content (r2 = 0.878) and total flavonoid content (r2 = 0.936) were found. The results obtained in this study highlights the nutritional value and the antioxidant potential of this vegetative parte of the plant, an inexpensive source of natural antioxidants beneficial for the humans health.
Benefits of understanding the enzymatic activities in saline Lake Letea in the Danube Delta
Authors:   Institute of Biology Bucharest of the Romanian Academy, Bucharest, Romania, LUCACI ANCA IOANA , NEAGU SIMONA , COJOC ROXANA , RUGINESCU ROBERT , ARDELEAN IOAN , ENACHE MĂDĂLIN
Published: April 2021

The purpose of this paper was to isolate halophiles from Letea saline lake and to performed a screening for industrially relevant extracellular enzymes. The investigations were conducted from October 2016 until May 2018. After a random selection of colonies that grew on the medium culture, 82 isolates were investigated. Based on their salt requirements and tolerance, it was remarked the presence of isolates belonging to halotolerant and moderate halophilic bacteria. Morphological and biochemical tests were used to characterize them. The ability of the tested isolates to produce extracellular enzymes was evaluated on the culture medium with salinity varying between 0-4M and supplemented with a specific substrate. The highest hydrolytic activities were recorded for casein at 0M NaCl, 1M NaCl, 2M NaCl, and Tween 80 and inulin at 0M NaCl, 1M NaCl, 2M NaCl, and 3M NaCl.
Genetic diversity in westernmost European populations of Halimione verrucifera (M. Bieb.) Aellen
Authors:   Institute of Biology Bucharest, Romanian Academy, Bucharest, Romania, VLADIMIRESCU MIHNEA , PAICA IOANA CĂTĂLINA ,   Institute of Biology Bucharest, Romanian Academy, Bucharest, Romania, BANCIU CRISTIAN ,   Institute of Biology Bucharest, Romanian Academy, Bucharest, Romania, MARIA GABRIEL MIHAI ,   Institute of Biology Bucharest, Romanian Academy, Bucharest, Romania, MANOLE ANCA ,   Institute of Biology Bucharest, Romanian Academy, Bucharest, Romania
Published: April 2021

Halimione verrucifera – an extreme halophyte plant species spread mainly in Asia with a few locations in South Eastern Europe – have the westernmost marginal populations in Romania. In order to asses population fitness and conservation status, genetic diversity among and within population was estimated using ISSR markers.A set of 6 primers were utilized after selection from a primer set which showed clear and reproducible banding patterns, generating a total number of 86 loci. A presence/absence matrix was generated by evaluating the gel electrophoresis banding patterns of PCR products. From this, genetic distances between individuals and populations were calculated, which were used in all subsequent generation of genetic diversity indices, assuming the Hardy-Weinberg equilibrium. Result revealed a low expected heterozygosity for both populations. Further testing by constructing an UPGMA dendrogram and a PCoA analysis confirmed that populations are clearly separated and with levels of genetic diversity that could ensure population survival in time and space.
Underestimated risks for bacterial keratitis in contact lens usage
Authors:   Medical University of Sofia, Bulgaria, Department of Ophthalmology, Alexandrovska University Hospital, Sofia, Bulgaria, MARINOVA EVELINA MILCHEVA , DABOV DIMITAR STOIMENOV ,   Medical University of Sofia, Bulgaria, Department of Ophthalmology, Alexandrovska University Hospital, Sofia, Bulgaria, ZDRAVKOV YANI TODOROV ,   Medical University of Sofia, Bulgaria, Department of Ophthalmology, Alexandrovska University Hospital, Sofia, Bulgaria, NASEVA EMILIA KRASIMIROVA ,   Medical University of Sofia, Faculty of Public Health, Sofia, Bulgaria
Published: April 2021

Objective: The purpose of our research is to emphasize the role of underestimated predisposing conditions for microbial keratitis in contact lens users, to draw attention to the complications of wearing contact lenses without ophthalmic examination, and to offer a short questionnaire for fast and easy estimation of the risk factors for bacterial keratitis. Methods: A series of 23 cases of healthy young individuals, treated for bacterial keratitis, provoked а research on the predisposing factors for its development. Results: 55% of the patients had started to wear contact lenses without specific examination. 75% had made mistakes in the hygiene and storage of the lenses. We identified risk factors for development of bacterial keratitis in all cases. Conclusions: A thorough anamnesis and ophthalmic examination are crucial in decision making about contact lens wearing because they could reveal some of the predisposing conditions for the occurrence of ocular complications. The usage of contact lenses without a prescription poses health risks and could have a negative impact on the social and healthcare system.
Arbuscular mycorrhizae colonization dynamic in Iris pseudacorus L. during second year after inoculation and planting in field
Authors:   University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania, CRIȘAN IOANA , VIDICAN ROXANA ,   University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania, MOREA ADRIANA ,   University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania, LAGUNOVSCHI VIORICA ,   University of Agronomic Sciences and Veterinary Medicine Bucharest, Romania
Published: April 2021

In the last few years was observed an unprecedented market expansion of microbial inoculants for agriculture and environmental applications. Fungi from the phylum Glomeromycota can establish symbiosis with roots of more than 70% vascular plant species, ensuring enhanced nutrient uptake. Aim of this study was to assess functional integration of inoculated arbuscular mycorrhiza and implications for success of symbiose in field conditions and host fitness. Iris pseudacorus was used as perennial model plant for study of seasonal continuity and persisting effects in second year after inoculation. During 2019 was conducted Trouvelot microscopic evaluation for 1080 stained root samples and parameters were obtained using Mycocalc. Results showed that colonization was significantly influenced by phenophase. Inoculated plants presented values with 1.56-14.49% higher. Plant height correlated significantly positive with inoculation (r=0.336*). Results showed that colonization parameters are useful indicators in tracking symbiose across a temporal gradient.
Analysis of the agricultural labor force and its impact on agricultural products obtained in the South-Muntenia region
Authors:   University of Agronomic Sciences and Veterinary Medicine Bucharest, 59 Marasti, Romania, TEODORESCU FLORINA RUXANDRA , MĂRCUȚĂ LIVIU ,   University of Agronomic Sciences and Veterinary Medicine Bucharest, 59 Marasti, Romania, COMAN CĂTĂLINANICOLETA ,   University of Agronomic Sciences and Veterinary Medicine Bucharest, 59 Marasti, Romania, TUDOR VALENTINA CONSTANȚA ,   University of Agronomic Sciences and Veterinary Medicine Bucharest, 59 Marasti, Romania
Published: April 2021

This paper aims to highlight the impact that the labor force in the agricultural sector has on the production obtained from the main crops in the South-Muntenia development region, Romania, in the period 2014-2018. Following the study of theoretical aspects in the fields mentioned above and combining these studies with the interpretation and analysis of statistical data, an analysis will be established to establish the level at which the agricultural labor force in the South-Muntenia region impacts the productions of five important crops. Romanian agricultural sector, respectively: wheat, corn, sunflower, rapeseed and soybeans. In the South-Muntenia region, made up of Argeș, Călărași, Dâmbovița, Giurgiu, Ialomița, Prahova and Teleorman counties, the percentage of people working in the agricultural sector in 2018 was 27.8% of the total population of this region.
In silico investigation of the potential interaction between two entomological peptides and human androgen receptor
Authors:   Biotehnos S.A., Otopeni, Ilfov, Romania, DRAGA SORIN , BUSE EMILIA ,   Biotehnos S.A., Otopeni, Ilfov, Romania, ENE DIANA ,   Biotehnos S.A., Otopeni, Ilfov, Romania, SERBU SABINA ,   Biotehnos S.A., Otopeni, Ilfov, Romania, PURCAREANU BOGDAN ,   Biotehnos S.A., Otopeni, Ilfov, Romania, OLARIU LAURA ,   Biotehnos S.A., Otopeni, Ilfov, Romania
Published: April 2021

Objective: We aim to evaluate the potential interaction of two insect hemolymph peptides, MDF3 and MDF4, with the human androgen receptor, on the premise that the proliferative effects of the two peptides are (at least in part) a consequence of AR binding. Methods: We employed a bioinformatic approach for the prediction of protein-peptide interaction and peptide aggregation, using various in silico on-line tools such as docking servers, aggregation prediction servers and visualization and analysis software in order to evaluate our results. Results: Our evaluation indicates that MDF3 and MDF4 interact with the androgen human androgen receptor by binding to a helix shown to be involved the receptor dimerization. Out of the two peptides, MDF3 appears to form a more extensive bond network with the receptor. Conclusion: Our analysis indicates that MDF 3 and 4 may be able to activate the human androgen receptor and warrant further investigation of the potential effect on receptor function. MDF3 appears to be the most promising out of the two peptides and its interaction should be further evaluated by both computational and experimental methods.
Biotechnological potential of plant associated microorganisms
Authors:   Laboratory of Useful Organisms, Res. Institute for Plant Protection, Blvd. Ion Ionescu de la Brad, 8, 013813, Bucharest, Romania, FENDRIHAN SERGIU , POP CRISTIAN-EMILIAN ,   Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90 Panduri Str., 050663, Bucharest, Romania
Published: April 2021

This paper shortly reviews the potential of plants associated microorganisms collectively termed “phytomicrobiome” (epiphytes, endophytes, root microbiome and phyllosphere microbiota), fungi and bacteria, that produce valuable molecules which can be use in pharma industry, in medicine and in different other industries as well as in environment protection and bioremediation. In the last ten years many papers on this subject were issued following scientific investigations, attracting the attention of the scientific community as an answer to some of our problems.
A method for in vivo tracking of mesenchymal stromal cells after intrapancreatic delivery
Authors:   Laboratory of Gene Regulation and Molecular Therapies, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania, FENYO IOANA MADALINA , VACARU ANA-MARIA ,   Laboratory of Gene Regulation and Molecular Therapies, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania, GAFENCU ANCA VIOLETA ,   Laboratory of Gene Regulation and Molecular Therapies, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania, PREDA MIHAI BOGDAN ,   Laboratory of Stem Cell Biology, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
Published: April 2021

Background and aim. The intrapancreatic injection of mesenchymal stromal cells may be a viable delivery route for experimental therapy in type 1 diabetes. Adequate in vivo cell imaging is important to evaluate the treatment efficiency, the fate of the transplanted cells, and the mechanisms of the effects observed. Here, we present a technique for delivering these cells into the mouse pancreas and tracking them using fluorescent near-infrared quantum dots and in vivo imaging. Methods and results. Bone marrow-derived mesenchymal stromal cells isolated from NOD mice were cultured and labeled with Qdots 800 nanocrystals, before being injected in the pancreas of pre-diabetic mice. In vivo analysis (IVIS Spectrum system) showed that the cells were successfully injected and remained localized in the pancreas for at least 24 hours. Conclusions. Labeling of mesenchymal stromal cells with Qdots 800 nanocrystals is a reliable method for in vivo cell tracking, after local delivery in the pancreas.
Correlation between DTI effect and white matter structural integrity, working memory in leukoaraiosis patients
Authors:   Department of Medical Imaging, Suizhou Hospital Hubei University of Medicine (Suizhou Central Hospital), Suizhou, 441300, PR China, YANG XIAOFENG , XIE WANMENG ,   Department of Medical Imaging, Suizhou Hospital Hubei University of Medicine (Suizhou Central Hospital), Suizhou, 441300, PR China
Published: April 2021

Our objective was to study the correlation between Diffusion tensor MR imaging (DTI) effect and white matter structural integrity, working memory in leukoaraiosis patients. 100 leukoaraiosis patients referring to the First Affiliated Hospital of Beijing Medical University from December 2018 to December 2019, were selected as study subjects and divided into four groups according to disease severity: lesion-free group, mild lesion group, moderate lesion group, and severe lesion group. All patients underwent magnetic resonance diffusion tensor imaging to collect DWI images and analyze Fractional anisotropy (FA), mean diffusivity (MD), ReHo values of white matter area under different grading. The patients’ working memory was tested via auditory verb learning test and Stroop color word test, so that correlation between white matter structural integrity and working memory can be analyzed. Results: There are statistically significant differences in FA values of the right posterior thalamic radiation, the right sagittal layer and the right superior longitudinal fasciculus, MD values of the right sagittal layer, the right cingulum bundle, the left cingulum bundle, the right inferior fasciculus fronto-occipitalis and the left inferior fasciculus frontooccipitalis, as well as instant recall, delayed recall, delayed recognition, card A (dot), card B (character), card C (color word) and SIE value (P<0.01). Correlation is shown between white matter structural integrity and working memory, gender, age, grading, disease course, recurrence interval, white matter area, and testing methods. There was a correlation between DTI effect and white matter structural integrity, working memory in leukoaraiosis patients, and leukoaraiosis patients have memory impairment.
O desenvolvimento de tumores cerebrais em idade pediátrica
Authors: Costa Elisângela Faustino Farias da , Silva Silvia Cristina Fürbringer e
Published: April 2021

Objetivo: Reunir informações recentes sobre tumores cerebrais na idade pediátrica, trazendo dados sobre os tipos mais comuns, descobertas sobre seu desenvolvimento, consequências em qualidade de vida, tratamentos e diagnósticos. Revisão bibliográfica: Os tumores malignos pediátricos geralmente afetam as células do sistema hematopoiético e os tecidos de sustentação, o que se explica por serem predominantemente de natureza embrionária, oriundos de células indiferenciadas, diferentemente do que ocorre com o câncer em adultos, que costuma afetar as células do epitélio. Os tumores cerebrais malignos ocupam entre o primeiro e o terceiro lugar em incidência e mortalidade por câncer em crianças, dependendo do país, e são a principal causa de morte por câncer nessa população. Entre os tumores cerebrais mais comuns na população pediátrica estão o meduloblastoma e o glioma. O uso de FET-PET parece ser mais preciso na diferenciação e avaliação de tumores cerebrais na idade pediátrica do que a ressonância magnética, devendo ser indicada quando houver dúvidas na identificação das lesões. Considerações finais: Ainda pouco se sabe sobre a etiologia do tumor cerebral na infância. Também se faz necessário um melhor direcionamento para os tratamentos desses tipos de câncer, o que vem sendo desenvolvido através de terapêuticas epigenéticas.
Perfil clínico de crianças internadas com vírus sincicial respiratório (VSR): análise em uma cidade do interior paulista de 2016 a 2017
Authors: Oliveira Franciele Rodrigues de , Souza Raquel de , Martins Roberto Salvador , Centeville Maraísa , Nascimento Christiane Ambrosio do , Martins Fernanda de Souza
Published: April 2021

Objetivo: Identificar e comparar o perfil epidemiológico e clínico de crianças com desconforto respiratório que realizaram teste rápido para VSR e/ou swab para o vírus H1N1 entre 2016 e 2017. Métodos: Os dados foram coletados do livro de controle dos testes para VSR e prontuários em um hospital no interior de São Paulo. Foram incluídas crianças menores de dois anos, com desconforto respiratório, que realizaram o teste para VSR e/ou swab para o vírus H1N1, de abril a junho de 2016 e 2017. Para análise estatística foram utilizados os testes Exato de Fisher e Mann-Whitney (significativo P=<0,05). Resultados: Em 2016, 84 crianças foram incluídas, com idade média de 6.1 meses, 42.9% apresentaram VSR positivo. Destas, 33.3% (P=0.0010) internaram na UTI, com tendência de maior uso (P=0.0933) e tempo em ventilação mecânica (P=0.0456). Em 2017, foram incluídas 165 crianças, com média de idade de 6.4 meses, 49.1% apresentaram VSR positivo. Destas, 86.1% (P=0.002) foram diagnosticadas com bronquiolite, 24.7% (P=0.031) utilizaram inalação hipertônica e 56.8% (P=0.016) oxitenda. Conclusão: A incidência do VSR foi maior em 2017, embora, em 2016, os pacientes com VSR positivo tenham internado com maior frequência em UTI, apresentando tempo mais prolongado e uso mais frequente da ventilação mecânica.
Fatores intervenientes do desmame precoce durante o aleitamento materno exclusivo
Authors: Araújo Shelda Cunha de , Souza Alane Dantas Araújo de , Bomfim Aiara Nascimento Amaral , Santos Josely Bruce dos
Published: April 2021

Objetivo: Identificar os fatores que interferem no desmame precoce durante o aleitamento materno exclusivo. Métodos: Trata-se de uma revisão integrativa, realizada no período de abril a outubro de 2020, utilizando um corte temporal de 10 anos, a fim de coletar informações das bases de dados Biblioteca Virtual Scientific Electronic Library Online (SciELO), Biblioteca Virtual em Saúde (BVS) e PubMed, com um quantitativo de 10 artigos utilizados para amostra final. A sistematização dos dados foi realizada pelo referencial teórico de Bardin. Resultados: Foram observados diversos fatores que intervêm no desmame, dentre eles os socioeconômicos, culturais, intercorrências mamárias, retorno da genitora ao trabalho, baixa escolaridade, uso de chupetas e ausência de orientação são os mais comumente encontrados. Considerações finais: A perpetuação do desmame é visto como um problema que interfere diretamente nas taxas de aleitamento materno exclusivo, fazendo necessária a atuação da enfermagem no acompanhamento nas e orientações às puérperas para promoção da amamentação.
Approach to: Chest pain
Authors: Haghandish Nasim
Published: April 2021

The diagnosis of chest pain is not always due to a cardiac cause such as a myocardial infarction. In fact, non-cardiac causes of chest pain may present with similar signs and symptoms. This article delves into the differential diagnosis of chest pain using an anatomical approach and describes how a thorough history, physical examination as well as specific tests are required to confirm each diagnosis.
Optimasi Kombinasi Biaya Bahan Bakar dan Emisi Pembangkit Energi Listrik menggunakan Teknik Reduksi Tempat Kedudukan
Authors: RAHARJO JANGKUNG
Published: April 2021

ABSTRAKDalam pengoperasian pembangkit energi listrik bukan saja untuk mendapatkan biaya yang minimal, namun juga meminimalkan emisi yang dihasilkan atau dikenal dengan Combined Economic Emission Dispatch (CEED), karena emisi merupakan bagian dari permasalahan energi. Makalah ini mengusulkan teknik reduksi tempat kedudukan untuk memecahkan masalah CEED. Prinsip dasar dari teknik ini adalah menebarkan sejumlah kandidat pada tempat kedudukan, S0 yang dibentuk dari limit daya generator, dan ditentukan sebuah kandidat terbaik. S0 diperkecil dan proses diulangi hingga didapatkan tempat kedudukan yang sangat kecil dimana kandidat terbaiknya dapat dianggap sebagai titik optimal. Teknik ini lebih akurat dibandingkan dengan metoda lain seperti Gradient Method (GM), Ant Colony Optimization (ACO), Particle Swarm Optimization (PSO), JAYA Algorithm dan Whale Optimization Algorithm (WOA). Hasilnya memberikan penghematan biaya tanpa melibatkan emisi masing-masing terhadap GM, ACO, PSO, WOA dan JAYA sebesar 9,24%, 3,91%, 0,56%, 0,47% dan 0,21%, serta bila melibatkan emisi sebesar 21,28%, 16,09%, 5,52%, 5,31% dan 5,04%.Kata kunci: CEED, reduksi tempat kedudukan, penghematan biaya, optimal, akurat. ABSTRACTIn an operating, generator units not only to get minimal costs but also to consider the emissions produced, known as the Combined Economic Emission Dispatch (CEED), because emission is part of the energy problem. This paper proposes a feasible area reduction technique for solving CEED problems. The basic principle of this technique is to spread number of candidates on a feasible area, S0 which is formed by generator limits from n generator units and the best candidate is determined. S0 is reduced and the process is repeated until a very small area is found, where the best candidate can be considered the solution. This technique is more accurate than other methods such as GM, ACO, PSO, JAYA Algorithm and WOA. The result provides cost savings without involving emission of GM, ACO, PSO, WOA and JAYA of 9.24%, 3.91%, 0.56%, 0.47% and 0.21% respectively, as well as when it involves emissions amounted to 21.28%, 16.09%, 5.52%, 5.31% and 5.04% respectively.Keywords: CEED, feasible area reduction, cost saving, optimal, accurate
Evaluasi Kinerja Efisiensi Energi Mesin Bubut Melalui Penilaian Indikasi Specific Energy Consumption
Authors: HARJA HERMAN BUDI , FAUZI MOHAMMAD , FATHAN ASEP
Published: April 2021

ABSTRAKKondisi ketidakselarasan sistem transmisi pulley-belt pada mesin bubut berpengaruh terhadap nilai inefisiensi konsumsi energi mesin perkakas. Penelitian ini bertujuan untuk melakukan kajian evaluasi kinerja efisiensi energi mesin bubut pada kondisi sistem transmisi pulley-belt mesin yang selaras dan tidak selaras. Kajian ini menggunakan metoda penilaian indikasi specific energy consumption (SEC) dari proses pemesinan bubut. Nilai total konsumsi energi saat proses pemotongan diukur menggunakan power analyzer, dan diolah menjadi nilai data SEC, kemudian dianalisis menggunakan Data Envelopment Analysis untuk mendapatkan harga referensi. Penilaian skor penurunan energi setiap mesin diperoleh dengan membandingkan jarak nilai SEC setiap mesin terhadap nilai referensi. Obyek penelitian menggunakan lima buah mesin bubut uji berkapasitas daya medium. Hasil kajian menunjukkan bahwa pada kondisi ketidakselarasan sistem transmisi pulley-belt menyebabkan terjadinya inefisiensi energi mesin bubut sebesar 5%.Kata kunci: Data Envelopment Analysis ,efisiensi energi, ketidakselarasan, SEC ABSTRACTThe pulley belt transmission system's misalignment condition on turning machine affects the low-efficiency value of machine tool energy consumption. This study aims to evaluate the energy efficiency of a lathe in the alignment and misalignment of the pulley-belt transmission system. This study used a method of assessing the specific energy consumption (SEC) of the lathe machining process. During the cutting process, the total energy consumption value is measured using a power analyzer and processed into SEC data values, then analyzed using Data Envelopment Analysis to obtain a reference value. The assessment is obtained by comparing the distance between each machine's SEC value and the reference value. The case study's object was conducted on five test lathes with medium power capacity. The study results show that the pulleybelt transmission system's misalignment causes the lathe's energy inefficiency of more than 5%.Keywords: Data Envelopment Analysis, efficiency energy, misalignment, SEC
Decision-making by Heads of Academic Department using Student Evaluation of Instruction (SEI)
Authors: Alkathiri Mohammed Saleh
Published: April 2021

This study investigates the ways in which heads of academic department use student evaluation of instruction (SEI) to make decisions about individual faculty members and/or whole academic departments. The study utilized a convenience sample of 57 heads of department, who completed an online questionnaire with two main constructs, which were assessed at the interval level of measurement. The results of the study revealed significant differences between heads of department who tend to trust SEI results compared to those who tend not to trust SEI results. The findings suggest there is a significant association between how heads of department perceive SEI and how they use it to make decisions about individual faculty members and their academic departments. In addition, analysis of the respondents as per two groups, according to their attitudes of trust or distrust toward SEI, showed that disparities within these groups were greater with respect to issues or decisions that affect individuals as opposed to whole departments. Therefore, the study concludes that decisions should not be made based solely on the results of SEI; rather, multiple sources of evaluation should be utilized to make proper decisions. The author strongly recommends that academic leaders should use SEI across multiple years or courses in order to obtain more reliable information. Future research may include qualitative studies on the topic and discipline-specific studies within certain academic departments or college clusters.
PUTUSNYA PERKAWINAN AKIBAT SUAMI MENIKAH TANPA IZIN DARI ISTRI
Authors: Zulkifli Suhaila
Published: April 2021

Marriage is one of the Sunnahtullah that applies to all creatures created by Allah SWT, including humans, animals and plants. Marriage is defined as an agreement between men and women. Many families experience destruction because each individual runs without a clear guideline, as contained in Islamic teachings about marriage. Divorce is essentially a process in which the relationship between husband and wife does not meet harmony in marriage anymore. Regarding the definition of divorce, the marriage law does not regulate explicitly, but only determines that divorce is only one reason for the breakup of marriage besides other causes, namely death and court decisions. In this study, the author's team discussed a problem regarding the termination of marriage caused by a husband who is married without his wife's permission. The research is a normative juridical study using legislation review approach, and this study also applies primary, secondary and tertiary legal materials. The writing technique made by the writing team is descriptive analytical by which the obtained data is then arranged systematically to be subsequently analyzed to reach a conclusion. Keywords: marriage, polygamy, divorce
Perlindungan Hukum Pemegang Hak Atas Tanah Terhadap Objek Yang Sama (Studi Putusan Nomor putusan 55 Pdt. G.2007/PN.RAP)
Authors: Braja Satria
Published: April 2021

The purpose of writing this article is to find out and to analyze whether the rights to land under the hands without being attended by witnesses can be justified by law and how legal protection of the holders of land rights is applied to the same object. The research method used in writing this article is normative research that uses a statue approach and conceptual approach. Based on the results of the study, the authors obtained answers to the problems; whether the above legal protection has fulfilled the basic elements Legal protection on land in fact it has a certificate on the same object so that mastery and ownership cause injustice. Responding to the things mentioned above, it is concluded that land is an inseparable part of human life and life so that land rights are human rights that legally contain control and ownership. Keywords: Legal protection, Land rights, the same object
TINJAUAN YURIDIS TERHADAP TINDAK PIDANA PERMAINAN JUDI JACKPOT (Studi Kasus Putusan Nomor 45/Pid.B/2017/PN.MDN)
Authors: J.P Sagala Mesias
Published: April 2021

Indonesia is a legal state where all aspects of people's lives in nation have norms that must be obeyed. These norms aim to prevent criminal acts. Criminal act is an act that is prohibited by the rule of law, and the prohibition is accompanied by threats and sanctions in the form of criminal violations of such prohibitions, such as gambling which is an act of betting deliberately carried out to benefit from a match, game or event that is uncertain about the result. For example, jackpot gambling games that use machine technology are played by inserting coins in the form of chips of money that have been exchanged for a certain value of money and inserted into the machine and then pulled by the player, then waiting for the combination image to come out simultaneously on the jackpot machine and if the image is the same, then it is considered to win a different cash prize depending on the interest or image that the player gets. This game is a chancy game that can be said as gambling because of bets between players. Keyword: Criminal Act, Gambling, Jackpot Gampling
Sensitivitas pp 78 tahun 2015 Tentang pengupahan
Authors: Affan Ibnu
Published: April 2021

The establishment of UMP/UMK based on PP on wage is accomplished in a simple way without making survey on price. The minimum wage is determined on this PP is made by using the formula of minimum wage calculation in KHL in accordance with the productivity and economic growth. With this calculation, the rise of minimum wage could be estimated either by the employee / labor, or the entrepreneurs every year. Furthermore, it will give warranty to the entrepreneur in their entrepreneurship.  The presence of PP on wage, in fact, triggers many rejections from employee/labor because it is in contradictory with the Act of Employment which results disadvantages for employee/labor because the determination of UMK/UMP will be made without the Union of Labors but it will be decided directly by the governor without any recommendation from the regent/mayor. Keyword : Sensitivity Pp 78 Year 2015 On Wage
Kewenangan Dan Ruang Lingkup Otoritas Jasa Keuangan Di Bidang Perbankan
Authors: Harahap Nurasiah
Published: April 2021

The Financial Services Authority (OJK) is a financial service supervision institution such as the Banking Industry, Capital Market, Mutual Funds, Financing Companies, Pension Funds and Insurance. OJK has become an independent institution based on the Law Number 21 Year 2011 concerning OJK, which means it is free from intervention or interference from any party. The purpose of the establishment of OJK is  that all activities in the Financial Services sector are carried out regularly, fairly, transparently and accountably; able to realize a financial system that grows in a sustainable and stable manner; and able to protect the interests of consumers and society.OJK has duties and authorities in the field of micropudential, which includes regulation and supervision of bank institutions, bank health, prudential aspects of banks, and bank checks. Whereas in the micropudential field, OJK's role is to assist Bank Indonesia (BI) to make moral appeals to the Banking Industry. Keywords: Financial Services Authority, Banking
Perlindungan Hukum Terhadap Penetapan Status Covid-19 Pada Pasien Penyakit Umum Oleh Rumah Sakit Di Kota Medan
Authors: Suryani Dewi Ervina
Published: April 2021

The government poured out the budget of trillions as a form of seriousness in handling the coronavirus outbreak which began to spread in Indonesia in the early of 2020. The amount of subsidized funds for the care of covid-19 patients provided by the government to hospitals is used by rogue hospital personnel to reap huge profits by convicting patients who are suffering from other diseases so that they have the status of covid-19 patients (not covid-19, sentenced to covid-19). This research is a type of normative legal research which is conducted by examining the library materials or secondary data. The secondary data in the form of primary legal materials, secondary legal materials, and tertiary legal materials used in this study were obtained through books, government publications, internal organizational records, reports, journals, and various sites related to coronavirus. The secondary data obtained are then processed by using library research data collection techniques (library research). The study is then analyzed qualitatively through the descriptive analytical method, so that a general conclusion is obtained about the coronavirus. The results showed that the form of legal protection against the determination of Covid-19 status in patients with general illnesses by hospitals in Medan was in the form of compensation. This refers to the Law Number 8 of 1999 concerning Consumer Protection and Law Number 36 of 2009 concerning Health. Keywords: Legal Protection, Covid-19
Hubungan hukum antara pt. Bank tabungan negara (persero) tbk. Kcp sutomo di kota medan dengan pengembang dan nasabah peminjam pada kredit pemilikan rumah inden
Authors: Hasyif Azansyah
Published: April 2021

People’s Housing Credit (KPR) by indent, as the product of PT Bank Tabungan Negara (Persero), is buying houses which have not been built by contractors by credit system. The houses will be built when the contract is signed by the prospective buyers who have ordered the houses. The Bank is vulnerable to the risk of developers’ default in building the houses; it is also take the risk of the default the debtors who are not able to pay the installment while the houses are being built. It is necessary to study the legal realationship in giving KPR by indent so the research was done at PT Bank Tabungan Negara (Persero), Tbk, KCP Sutomo, Medan. The research used juridical normative method with descriptive analytic approach, supported by primary data. The data were gathered by conducting library research, field study, documentation, and interview and analyzed by using qualitative method. The legal relationship between PT Bank Tabungan Negara (Persero) Tbk KCP Sutomo with developers and borrowing customers in providing indent housing loans (KPR) is a form of tripatrit legal relationship, because of the cooperation agreement between Bank BTN and the developer and provision of credit between Bank BTN. and borrowing customers where the three parties each have rights and obligations.  Keywords: people’s housing credit, indent, prudential principle, bank
Forensic and pharmaceutical analysis of addictive morbidity because of the use of psychoactive substances in Ukraine
Authors:   Kharkiv medical academy of postgraduate education, Ukraine, Shapovalov V. V. ,   Advocates company «Apotheosis», Kharkiv, Ukraine,   Ukrainian national bar association, Kyiv, Gudzenko A. A. ,   Kharkiv medical academy of postgraduate education, Ukraine, Shapovalova V. A. ,   Kharkiv medical academy of postgraduate education, Ukraine, Shapovalov V. V. ,   Kharkiv medical academy of postgraduate education, Ukraine
Published: April 2021

Introduction. Modern turbulent state of society actualizes need for scientifically based methods and technological solutions to improve the information security system not only for the state, but also for society and the person in particular. Objective. To highlight the significant factors of information security of social development and to study the role of public admini-stration in the context of the actualization of information threats and risks. Study results. The article considers the essence of state management approaches to information security based on interpretation in terms of risk management. Information security is presented as a dynamic system that needs balance. Balance can be disturbed by external and internal factors. The 8 most significant factors that need to be taken into account to develop effective models of public administration in the field of information security are identified. 4 paradigms of information security management (systemic, synergetic, phenomenological and cognitive) which can be involved are considered. However, they are not universal and separate in any particular case, that is they are systemic in nature, and security management should be based on their integrated application depending on the situation and the specifics of the management process. Based on the analysis of the classical model of maintaining the state balance of a dynamic system, it is concluded that it can be used to ensure information security. A model is proposed to explain the reasons for the imbalance of the dynamic system of information security under the action of factors of influence and the risks that accompany them, and to determine the measures of public administration to ensure it. Conclusion. The model is proposed to explain the reasons for the imbalance of the dynamic system of information security under the action of factors of influence and the risks that accompany them, and to determine the measures of public administration to ensure it. Key words: Information security; Information security factors; Society; Public administration; Information security model.