bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of aromatherapy with lavender essential oil on the working memory of women with multiple sclerosis
Authors: Mohammad Rezaie Sara ,   Internal Surgery Nursing, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Shahabinejad Maryam ,   Department of Medical Surgical Nursing, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Loripoor Marzeyeh ,   Department of Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Reza Sayadi Ahmad ,   Department of Psychiatric Nursing, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Ahmad Reza Sayadi, Department of Psychiatric Nursing, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. E-mail: sayadiahmad@yahoo.com
Published: November 2022

Working memory, one of the cognitive components, may be impaired in patients with multiple sclerosis. Accordingly, this study aims to determine the effects of aromatherapy with lavender essential oil on the working memory of women with multiple sclerosis (MS). In this clinical trial, 60 women with multiple sclerosis were selected using the sampling method from patients referred to the MS Clinic of Rafsanjan. Based on the inclusion and exclusion criteria, the participants were randomly divided into intervention and placebo groups. In addition, the working memory test developed by Daneman and Carpenter was used to evaluate the participants’ working memory before the intervention and the day after the last intervention. The collected data were analyzed using SPSS Statistics version 18.0. According to intragroup comparison results and based on the paired t-test, the mean score of the working memory before the intervention in the intervention group was 82.77±6.87, which increased to 87.64±5.57 after the intervention (P<0.001). The average working memory score of the placebo group was 80.30±11.09 and 82.09±11.31 before and after the intervention, respectively, which did not have a statistically significant difference (P=0.154). Based on findings from the independent t-test, the mean scores of working memory had a statistically significant difference between the intervention and placebo groups after the intervention (P=0.02). According to the results from this study, aromatherapy with lavender essential oil improved working memory in women with multiple sclerosis.
Melatonin Levels Decrease in the Umbilical Cord in Case of Intrauterine Growth Restriction
Authors: Berbets Andrii Mykolaiovych ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine,   Andrii Mykolaiovych Berbets, PhD Student 2, Teatralna Sq, Chernivtsi, Ukraine, 58000.Phone: +380501714679 E-mail: andriy.berbets@gmail.com, Barbe Adrian Mykhailovych ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine, Andriiets Oksana Anatoliivna ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine, Andriiets Anatolii Volodymyrovych ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine, Yuzko Oleksandr Mykhailovych ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine
Published: November 2022

Intrauterine growth restriction (IUGR) is a common reason for perinatal morbidity and mortality. Also, it is often complicated with fetal distress. Melatonin is widely known as an anti-oxidant agent, and it might decrease the damage of tissues caused by hypoxia. It is also known that levels of pro- and anti-inflammatory cytokines are changed during pregnancy. Placental growth factor (PlGF) is responsible for the angiogenesis in the placenta. We aimed to investigate whether the level of melatonin, cytokines, and PlGF in umbilical blood after birth is different in the case of IUGR compared to normal fetuses. Fourteen women whose pregnancies were complicated with IUGR were included in the study group. The presence of IUGR was confirmed by ultrasound fetometry in the third pregnancy trimester, 30-36 weeks of gestation. All patients delivered their children vaginally after 37 weeks of pregnancy. The cases of severe fetal distress that required a caesarian section, obstetrical forceps, or vacuum extraction of the fetus were excluded from the study. We found that the concentrations of cytokines did not differ significantly between the groups. Also, no significant difference in the daytime of delivery was found between the groups. The concentrations of melatonin and PlGF in the umbilical blood at labor were significantly lowered in the case of IUGR compared to normal pregnancies. This fact, as we consider, is caused by altered production of melatonin and PlGF by the placenta. Therefore, the protective action of these two factors for the fetus at labor is decreased in IUGR.
Performance Evaluation on Rotary Preparation of Root Canal by Beginner Operators
Authors: Chirila Mihaela ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Suciu Ioana ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Ioana Suciu,Department of Endodontics, Faculty of Dentistry,„Carol Davila” University of Medicine and Pharmacy, Bucharest. E-mail: ioana.suciu@umfcd.ro, Dimitriu Bogdan ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Maru Nicoleta ,   Department of Clinical Anatomy and Topography, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Ecaterina ,   Department of Orthodontics and Dento-Facial Orthopedics, Faculty of Dental Medicine,“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Croitoru Georgiana Florentina ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Amza Oana ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

This study aims to analyze the performance of rotary root canal preparation, conducted by beginner operators (students). After acquiring the necessary skills involved in applying endodontic preparation techniques on extracted teeth, all students from a cohort learned to use ProTaper Universal files (Dentsply Maillefer). The preclinical training had several stages. Experience 1: instrumentation on extracted single-root teeth; Experience 2: instrumentation on EndoTraining blocks (Dentsply Maillefer); Experience 3: instrumentation on EndoTraining blocks (Dia Dent Group International); Experience 4: Instrumentation on extracted multiradicular teeth. Preparation was done according to the manufacturer’s instructions, the initial file is Sx, followed by S1, S2, F1, F2 and the last file is F3. A batch of 50 teeth (E1, E2, E3, E4) was randomly selected to evaluate the onset of the rotary preparation of young operators. Two independent evaluators analyzed the array radiologically by stereomicroscope evaluation (E1, E4) and photo-analysis of the resulting Endo Training blocks (E2, E3). The success rate was 80% for E1, 72% for E2, 64% for E3 and 76% for E4 (p<0.05). The following were considered a failure: ledge formation and apical transportation in 10.66%, over instrumentation in 6.66%, zipping in 3.33%, and instrument fracture in 4% of cases.

Endodontic instrumentation techniques require training to acquire the necessary skills. Rotary root canal instrumentation techniques used almost exclusively in modern endodontics require adequate preclinical training.
Antimicrobial effect of Red Roselle (Hibiscus Sabdariffa) against different types of oral bacteria
Authors: Abass Abeer Abdulridha ,   Department of Basic Science, Faculty of Dentistry, Kufa University, Najaf, Iraq,   Abeer Abdulridha Abass, Department of Basic Science, Faculty of Dentistry, Kufa University, Najaf, Iraq. E-mail: abeeraa.sc12p@uokufa.edu.iq, Al-Magsoosi Mohanad Jameel Najm ,   Department of Oral Diagnosis, College of Dentistry, University of Basrah, Basrah, Iraq, Kadhim Wijdan Abdulameer ,   Department of Conservative Dentistry, College of Dentistry, University of Karbala, Karbala, Iraq, Mustafa Ruba ,   Department of Conservative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan, Ibrahim Sana’a Abdulrazzaq ,   Department of Basic Science, Faculty of Dentistry, Kufa University, Najaf, Iraq, Aljdaimi Abtesam Imhemed ,   College of Dentistry and Oral Surgery, Alasmarya University, Zliten, Libya, Al-Nasrawi Suhad Jabbar ,   Department of Conservative Dentistry, Faculty of Dentistry, Kufa University, Najaf, Iraq, Hadi Najah Raiesh ,   Department of Pharmacology & Therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq, Haider Julfikar ,   Department of Engineering, Manchester Metropolitan University, Manchester, United Kingdom
Published: November 2022

This study aimed to compare the antimicrobial effect of an aqueous extract Red Roselle calyx (RE), Chlorhexidine (CH), Amoxicillin-clavulanic acid (ACA), Tetracycline (Tet), and Metronidazole (Met)on Streptococcus mutans (S. mutans), Staphylococcus aureus (S. aureus) and Enterococcus faecalis (E. faecalis) bacteria. The bacterial inhibition zones (BIZ)of the RE (25, 50, 75, 100) mg/ml and CH solutions (0.2%, 2%) were determined using the agar well diffusion method. Additionally, the susceptibility of the tested bacteria against (30 μg) of standard antibiotics of ACA, Tet, and Met was examined. The bacterial minimum inhibitory concentration (MIC) was measured using the Broth Micro dilution method (BMDM). All tests were carried out in triplicates, and water was considered the negative control. For S. mutans, the RE at 50 mg/ml or above concentrations displayed higher BIZ than 0.2% CH. 100 mg/ml of RE recorded a greater BIZ than the 2% CH. The greater BIZ against S. mutans was recorded by Tet. A comparable effect was found with 0.2% CH (75, 100) mg/ml of the RE against S. aureus. Greater BIZ for S. aureus and E. faecalis were reported for 100 mg/ml RE compared to the Tet and Met RE at 100 mg/ml inhibited the E. faecalis growth in a zone size comparable to the CH (0.2%, 2%).The RE with 50,100 mg/ml concentrations showed comparable antimicrobial effect to 0.2%, 2% concentrations of CH, respectively. As an herbal substitute for commercial disinfectants, the RE can be considered an effective final endodontic irrigant and dental mouthwash.
Antenatal care services utilization during COVID-19 second wave attack in Pasuruan, Indonesia
Authors: Ariani Novida ,   Midwifery Department, Faculty of Medicine, Brawijaya University, Malang, Indonesia,   Novida Ariani, Faculty of Medicine, Brawijaya University, Malang, Indonesia. E-mail: sharfuddinchowdhary7@gmail.com
Published: November 2022

Indonesia is currently experiencing the second wave of the COVID-19 pandemic, impacting maternal health services and maternal mortality. This research aims to investigate the use of antenatal care (ANC) during the COVID-19 second wave and the factors that play a role in this situation. A cross-sectional study was conducted during July 2021 on 344 pregnant women in primary, secondary, and tertiary maternal health care facilities in Pasuruan Regency, Indonesia. The data collection technique was simple random sampling, with face-to-face interviews assisted by questionnaires. Logistic regression and adjusted odds ratio with 95% CI and p<.05 were performed to identify a significant relationship. 136 (39.5%) pregnant women did not use ANC services during the second wave of the COVID-19 outbreak. Husband’s support (AOR=13.814, 95% CI: 8.090–23.588), believing that pregnant women are not afraid of contracting COVID-19 (AOR=6.501, 95% CI: 3.904–10.825), easy access to transportation (AOR=12.145, 95% CI: 6.186–23.846), ease of ANC fees (AOR=4.105, 95% CI: 2.424–6.950), no lockdown policy (AOR=3.130, 95% CI: 1.983–4.940), knowledge regarding COVID-19 (AOR=2.975, 95% CI: 1.793–4.938), COVID-19 information on social media (AOR=3.035, 95% CI: 1.179–7.815), COVID-19 prevention protocols in health facilities (AOR=8.478, 95% CI: 3.611–19.903) were predictors of ANC utilization. This encourages the importance of prioritizing health services for pregnant women during the pandemic, overcoming the fear of contracting COVID-19 through maternal education, husband support, easy access to ANC, and improving the quality of ANC service facilities.
Association of Covid-19 with blood type A in relation to blood sugar, urea, and blood test (D-dimer and ferritin) in patients from Al-Najaf
Authors: Hussein Hayfaa Jaber ,   Department of Basic Sciences, Faculty of Dentistry, University of Kufa, AL-Najaf, Iraq,   Hayfaa Jaber Hussein, Department of Basic Sciences, Faculty of Dentistry, University of Kufa, AL-Najaf, Iraq. E-mail: hayfaa.alabidi@uokufa.edu.iq https://orcid.org/0000-0002-9188-5339, Ibrahim Sana’a Abdulrazzaq ,   Department of Basic Sciences, Faculty of Dentistry, University of Kufa, AL-Najaf, Iraq https://orcid.org/0000-0002-4201-705X, Al-Shaibani Shurooq Wesam ,   Department of Basic Sciences, Faculty of Dentistry, University of Kufa, AL-Najaf, Iraq https://orcid.org/0000-0002-9935-2238, Abdulrudha Noor Hassan ,   Department of Basic Sciences, Faculty of Dentistry, University of Kufa, AL-Najaf, Iraq https://orcid.org/0000-0002-3067-4300
Published: November 2022

COVID-19 is an emerging infectious disease caused by the novel enveloped single-stranded RNA virus quickly declared a pandemic. This study aimed to investigate the severity of COVID-19 infection in patients with blood group type A. A cross-sectional study was conducted at Al-Amal specialized hospital, Al-Najaf (March 8 to March 20/2021). The study included 123 hospitalized patients (63 females and 60 males), aged between 15-95 years, diagnosed with COVID-19, tested for blood group, blood sugar, blood urea, D-dimer, and serum ferritin. Results indicated significant differences in blood sugar and D-dimer in patients with type A blood group at P>0.05. At the same time, no significant difference was found in blood urea and ferritin at P>0.05. The majority of patients showed elevated levels of blood sugar, blood urea, serum D-dimer and ferritin. COVID-19 can infect people of all ages and causes severe infection in all blood groups.
The optimum inhibitory effects of Alpha Interferon and Cisplatin in colon cancer, a comparative in vitro study
Authors: Muttar Arafat ,   1. Ministry of Higher Education and Scientific Research, Baghdad, Iraq,   Arafat Muttar, Ministry of Higher Education and Scientific Research, Baghdad, Iraq. E-mail: arafataam3@yahoo.com, Ahmed Ihab ,   Department of Pharmacology, College of Pharmacy, Al-Bayan University, Baghdad, Iraq, Hameed Hudaa ,   Department of Pharmacology, College of Pharmacy, Al-Bayan University, Baghdad, Iraq
Published: November 2022

Cisplatin is well known as a potent anti-cancer agent against colon cancer. However, alpha interferons are also widely used for cancer suppression. This in vitro study was designed to investigate and compare the cancer suppression function of alpha interferon in colon cancer with Cisplatin. The analysis used a human SW 480 cancer cell line with RPMI-1630 culture media. Six dilutions of interferon (2.5 μg/ml, 1.25 μg/ml, 0.562 μg/ml, 0.286 μg/ml, 0.143 μg/ml, and 0.057 μg/ml) and six dilutions of cisplatin (100 μg/ml, 50 μg/ml, 25 μg/ml, 6.25 μg/ml, and 3.125) were used at 24, 48 and 72 hours along with the presence of control groups. Following this, results were observed by ELISA plate reader, and percentage inhibition was calculated using ANOVA analysis. The interferon and cisplatin percentage of inhibition was comparable with higher inhibition rates observed with alpha interferon. The statistical analysis showed that the maximum inhibition was observed at a 0.143 μg/ml interferon concentration when exposed for 48 to 72 hours. This in vitro analysis demonstrated the anti-cancer activity of alpha interferon and its advanced inhibitory activity compared to Cisplatin.
Quantitative CK19 biomarker detection in breast cancer cell lines
Authors: Orafa Zahra ,   Molecular Biology Department, Pasteur Institute of Iran, Tehran, Iran https://orcid.org/0000-0002-4723-5021, Karimi Nasrin ,   Molecular Biology Department, Pasteur Institute of Iran, Tehran, Iran, Keyvani Saeideh ,   Molecular Biology Department, Pasteur Institute of Iran, Tehran, Iran, Oloomi Mana ,   Molecular Biology Department, Pasteur Institute of Iran, Tehran, Iran,   Mana Oloomi, Molecular Biology Department, Pasteur Institute of Iran, Pasteur Ave., Tehran-Iran 13164. E-mail: manaoloomi@yahoo.com https://orcid.org/0000-0002-4723-5021
Published: November 2022

Cytokeratin19 (CK19) was detected as the most related marker for circulating tumor cells, which was assessed in specific cell lines. MCF7, SKBR3, T47D, and MDA-MB-231, and HeLa cell line as negative control were used. CK19 expression was confirmed by using mouse monoclonal anti-human CK19 antibody. CK19 detection in MDA-MB-231 was not observed. CK19 marker expression was compared in T47D, MCF7, and SKBR3 cell lines. T47D and MCF7 belonged to the luminal subtype of breast cancer (BC) that CK19 expression regulated with an ER marker. SKBR3 belonged to the HER2 positive subtype of BC. However, MDA-MB-231 belonged to the claudin-low subtype of BC that lack of CK19 expression strongly is related to negative ER, PR, and HER2. Therefore, there are not only quantitative differences in CK19 expression, but its expression could also link to the other markers of BC that should be considered in the molecular classification of breast carcinoma. Different expression levels related to cell classification could be useful in the prognosis and treatment of cancers with epithelial origins.
Diet, fibers, and probiotics for irritable bowel syndrome
Authors: Galica Adelina Nicoleta ,   2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   2. Department of Nursing, Faculty of Natural and Human Sciences, Fan S. Noli University, Korçe, Albania,   Adelina Nicoleta Galica, 2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Nursing, Faculty of Natural and Human Sciences, Fan S. Noli University, Korçe, Albania. E-mail: adelinagalica2016@gmail.com, Galica Reitano ,   Department of Obstetrics and Gynecology, Regional Hospital Korçe, Korçe, Albania, Dumitrașcu Dan Lucian ,   2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: November 2022

Many aspects make irritable bowel syndrome (IBS) challenging for both patients and physicians. The unclear pathogenesis with many pathways to be explored, bothering symptoms that affect the quality of life, and many subtypes of the condition are only a few reasons that make IBS difficult to control and obtain satisfactory results. Treatment options start with general advice for lifestyle, continue with non-pharmaceutical treatments, and finally touch classic treatments. In this review, pharmaceutical treatment options are not accounted for. Consensus groups and meta-analyses have concluded guidelines that overall are the same, with variations in the strength of recommendations and some cultural and geographical particularities. Dietary interventions, probiotics, and fibers can be seen as non-pharmaceutical treatments that coexist in various protocols because of the relevant evidence regarding their efficacy in treating IBS symptoms.
Support in the Battle against COVID-19: A National Qualitative Study among Midwives in Indonesia
Authors: Gayatri Mergy , Akingbade Oluwadamilare , Adesuyi Emmanuel , Oyekale Rahmat , Oluwabunmi Faremi , Oluwatomi Olufayo , Kusumaningtyas Dian , Sujarwoto Sujarwoto
Published: November 2022

The outbreak of the novel coronavirus disease (COVID-19) in 2019 was met with various responses globally in an effort to reduce its spread. Despite these efforts, however, low- and middle-income countries like Indonesia are still being confronted with challenges, especially the healthcare providers who are frontline workers in the struggle. The current study aimed to explore the support expected by and provided to Indonesian midwives and pregnant women during the COVID-19 pandemic. The research method used was a descriptive-interpretative qualitative research design. The data was collected through conducting in-depth interviews with 24 midwives who were purposively sampled and evenly recruited across all regions and all areas of midwifery practice in Indonesia. The recorded interviews were coded and themes were identified, after which a thematic analysis was done. Two main themes emerged and nine sub-themes were identified from the main themes. The study findings offered new insights into the individual and collective experiences of midwives from various regions in Indonesia. They had to adjust by leveraging the internet and mobile telephones in order to continue delivering standard care to pregnant women amid the pandemic. In addition, the midwives saw the need to provide food and financial support to pregnant women. However, despite the end of the pandemic being in sight in September 2022, there is a need to continue to support midwives and pregnant women in the disruption caused by the pandemic. Government agencies and non-governmental organisations (NGOs) should plan interventions targeted at providing specific support to midwives and pregnant women.
Mining the Milky Way: How to Bring America’s Extraterrestrial Excursions Back Into Compliance With International Obligations
Authors: Anderson Braden N.
Published: November 2022

In November of 2015, the 114th United States Congress enacted the Commercial Space Launch Competitiveness Act of 2015 (Space Act) and, in turn, thrusted the door to outer space mining wide open for Americans. Unfortunately, while the Space Act provided a solution for corporations, it created a di- lemma for the United States. As currently enacted, the Space Act directly conflicts with the world’s foundational and most basic framework for international space law: The Treaty on Principles Governing the Activities of States in the Exploration and Use of Outer Space, Including the Moon and Other Celestial Bodies (Outer Space Treaty). To reassure other signatories and to ensure the United States complies with its international obligations under the Outer Space Treaty, Congress should establish a centralized regulatory authority to govern the activities of American entities in outer space and amend the Space Act to require bonding and permit- ting processes for entities wishing to engage in asteroid mining. This Article is the first to analyze how to modify existing legislation to impose sufficient regulation so the United States may once again comply with its international obligations under Article VI of the Outer Space Treaty. This Article will show that given the inherent risks of outer space mining, the intent and origins of the Outer Space Treaty, and the conflicting allowances contained in the Space Act, changes must be enacted to ensure that the tradition of treaty compliance and mineral- extraction regulation does not stop at our planet’s troposphere.
Impact of inpatient rehabilitation on quality of life among stroke patients
Authors: Khanna Meeka , Sivadas Dhinla , Gupta Anupam , Haldar Partha , Prakash Navin B.
Published: November 2022

Objective:

Despite remarkable progression in the treatment of stroke, the life quality and social related events caused by stroke have received limited attention in our country. Quality of life (QOL) assessment is an important part of the evaluation of stroke patients and their management. The objective of this study was to assess QOL in patients with stroke at the time of admission in rehabilitation unit and to assess the impact of inpatient rehabilitation on change in QOL in these patients.

Materials and Methods:

Adult patients with first arterial stroke of any duration, with presentation as hemiplegia, were recruited. The clinical outcome scales and 36-Item Short Form Health Survey (SF-36) parameters for QOL were assessed at both admission and discharge. The scales used were Scandinavian stroke scale (SSS), Barthel Index (BI), and modified Rankin Scale. SF-36 scores were assessed after 6 weeks of discharge also.

Results:

Ten patients with median age of 36.5 years and median duration of stroke 75 days were recruited. There was significant improvement in functional scores of BI and SSS scales at the time of discharge. Majority of the components of both physical and mental domains of QOL SF-36 questionnaire showed significant improvement. The QOL scores after 6 weeks of discharge did not show significant change except for the emotional well-being.

Conclusion:

The QOL in patients with stroke improves with inpatient rehabilitation along with motor and functional scores. Improved functional independence leads to better emotional state after discharge also.
Development and internal validation of a nomogram to predict massive blood transfusions in neurosurgical operations
Authors: Sungkaro Kanisorn , Taweesomboonyat Chin , Kaewborisutsakul Anukoon
Published: November 2022

Objectives:

A massive blood transfusion (MBT) is an unexpected event that may impact mortality. Neurosurgical operations are a major operation involving the vital structures and risk to bleeding. The aims of the present research were (1) to develop a nomogram to predict MBT and (2) to estimate the association between MBT and mortality in neurosurgical operations.

Material and Method:

We conducted a retrospective cohort study including 3660 patients who had undergone neurosurgical operations. Univariate and multivariate logistic regression analyses were used to test the association between clinical factors, pre-operative hematological laboratories, and MBT. A nomogram was developed based on the independent predictors.

Results:

The predictive model comprised five predictors as follows: Age group, traumatic brain injury, craniectomy operation, pre-operative hematocrit, and pre-operative international normalized ratio and the good calibration were observed in the predictive model. The concordance statistic index was 0.703. Therefore, the optimism-corrected c-index values of cross-validation and bootstrapping were 0.703 and 0.703, respectively.

Conclusion:

MBT is an unexpectedly fatal event that should be considered for appropriate preparation blood components. Further, this nomogram can be implemented for allocation in limited-resource situations in the future.
Awake brain surgery for autistic patients: Is it possible?
Authors: Drosos Evangelos , Maye Helen , Youshani Amir Saam , Ehsan Sheeba , Burnand Cally , D’Urso Pietro Ivo
Published: November 2022

Background:

Awake neurosurgery is currently the mainstay for eloquent brain lesions. Opting for an awake operation is affected by a number of patient-related factors. We present a case of a patient with autistic spectrum disorder (ASD) that was successfully operated for a brain tumor through awake craniotomy. To the best of our knowledge, this is the first reported case in the literature.

Case Description:

A 42-year-old patient, with known ASD since his childhood, underwent awake craniotomy for a left supplementary motor area tumor. Detailed preoperative preparation of the patient was done to identify special requirements and establish a good patient-team relationship. Intraoperatively, continuous language and motor testing were performed. Conversation and music were the main distractors used. Throughout the operation, the patient remained calm and cooperative, even during a focal seizure. Mapping allowed for >80% resection of the tumor. Postoperatively, the patient recovered without any deficits.

Conclusion:

This case shows that with growing experience and meticulous preparation, the limits of awake craniotomy can be expanded to include more patients that were previously considered unfit.
Development of posttraumatic frontal brain abscess in association with an orbital roof fracture and odontogenic abscess: A case report
Authors: Abdulrazeq Hael , Walek Konrad , Sampath Shailen , Shaaya Elias , Beqiri Dardan , Woo Albert , Sampath Prakash
Published: November 2022

Background:

Brain abscess is a potentially fatal condition. Orbital fractures caused by penetrating injury may be associated with intracranial infection. Such complication associated with blunt trauma, orbital roof fractures, and odontogenic abscesses is exceedingly rare.

Case Description:

We report the case of a 40-year-old transgender female with a frontal abscess presenting several weeks following a motor vehicle crash from which she suffered multiple facial fractures and an odontogenic abscess. On computed tomography scan, the patient had multiple right-sided facial fractures, including a medial orbital wall fracture and a right sphenoid fracture extending into the superior orbital roof. There was hemorrhage notable in the right frontal lobe. Communication with the ethmoid sinuses likely provided a conduit for bacterial spread through the orbit and into the intracranial and subdural spaces.

Conclusion:

Skull base fractures that communicate with a sinus, whether it be frontal, ethmoid, or sphenoid may increase the risk of brain abscess, especially in patients who develop an odontogenic abscess. Surgical repair of the defect is essential, and treating patients prophylactically with antibiotics may be beneficial.
Spatially Controlled UV Light Generation at Depth Using Upconversion Micelles
Authors: Zhou Qi , Wirtz Brendan , Schloemer Tracy , Burroughs Michael , Hu Manchen , Narayanan Pournima , Lyu Junrui , Gallegos Arynn , Layton Colette , Mai Danielle , Congreve Daniel
Published: November 2022

Ultraviolet (UV) light can trigger a plethora of useful photochemical reactions for diverse applications, including photocatalysis, photopolymerization, and drug delivery. These applications typically require penetration of high energy photons deep into materials, yet delivering these photons beyond the surface is extremely challenging due to absorption and scattering effects. Triplet-triplet annihilation upconversion (TTA-UC) shows great promise to circumvent this issue by generating high energy photons from incident lower energy photons. However, molecules that facilitate TTA-UC usually have poor water solubility, limiting their deployment in aqueous environments. To address this challenge, we leverage a nanoencapsulation method to fabricate water-compatible UC micelles, enabling on-demand UV photon generation deep into materials. We present two iridium-based complexes for use as TTA-UC sensitizers with increased solubilities that facilitate the formation of highly emissive UV-upconverting micelles. Furthermore, we show this encapsulation method is generalizable to nineteen UV-emitting UC systems, accessing a range of upconverted UV emission profiles with wavelengths as low as 350 nm. As a proof-of-principle demonstration of precision photochemistry at depth, we use UV-emitting UC micelles to photolyze a fluorophore at a focal point nearly a centimeter beyond the surface, revealing opportunities for spatially controlled manipulation deep into UV-responsive materials.
Boron doping to limit sulfur poisoning on metal catalysts
Authors: Almofleh Ali , Aljama Hassan
Published: November 2022

Sulfur poisoning is a major challenge in catalytic processes where it can result in a gradual decline in the activity of the metal catalyst or a complete deactivation of the catalyst. Many studies were conducted to investigate the effects of sulfur poisoning on metals and address this challenge by developing a catalyst that is resistant to sulfur poisoning without compromising its performance. Boron doping showed to be a promising approach to modify the properties of metal catalysts and improve their performance in various applications. In this work, we conduct periodic density functional theory (DFT) calculations to study boron doping on a number of metals and its impact on sulfur poisoning. Our DFT calculations show that boron doping impacts metals differently. Boron doping is favourable on few metals (Pd, Pt, Rh and Ru) and very unfavourable on other metals (e.g. Ag and Cu). On Pd, Pt, and Rh, boron doping has a positive impact on reducing sulfur poisoning, with the impact varying with boron concentration. Finally, as a case study, we examine the impact of boron doping on H2S splitting to create H2 and show that boron doping has a pronounced positive impact on the performance of Pd-based catalyst.
Quantum-chemical calculation of two-dimensional infrared spectra using localized-mode VSCF/VCI
Authors: Brüggemann Julia , Wolter Mario , Jacob Christoph
Published: November 2022

Computational protocols for the simulation of two-dimensional infrared (2D IR) spectroscopy usually rely on vibrational exciton models, which require an empirical parametrization. Here, we present an efficient quantum-chemical protocol for predicting static 2D IR spectra that does not require any empirical parameters. For the calculation of anharmonic vibrational energy levels and transition dipole moments, we employ the localized-mode vibrational self-consistent field (L-VSCF) / vibrational configuration interaction (L-VCI) approach previous established for (linear) anharmonic theoretical vibrational spectroscopy [Panek and Jacob, ChemPhysChem 15, 3365–3377 (2014)]. We demonstrate that with an efficient expansion of the potential energy surface using anharmonic one-mode potentials and harmonic two-mode potentials, 2D IR spectra of metal carbonyl complexes and of dipeptides can be predicted reliably. We further show how the close connection between L-VCI and vibrational exciton models can be exploited to extract the parameters of such models from those calculations. This provides a novel route to the fully quantum-chemical parametrization of vibrational exciton model for predicting 2D IR spectra.
THE RECONSTRUCTING LEGAL POLICIES OF THE MANAGEMENT AND CONTROL OF ENVIRONMENTAL IMPACTS FOR INDUSTRIAL AREAS IN URBAN OF CENTRAL JAVA
Authors: Widodo Agus , Hossain Mohammad Belayet
Published: November 2022

The pace of development is often faced with the challenge of decreasing the quality of a healthy environment. Meanwhile, the management and control of impacts must continue to be pursued properly and committed to maintaining health and environmental sustainability. This article aims to describe how environmental management in the city of Semarang is amid the rapid industrial growth in the area and what obstacles and challenges are faced. This study uses an empirical juridical approach with qualitative analysis techniques. The study results indicate that the strategy for controlling environmental impacts includes developing priority programs and strategies. The program can be measured in a certain time with clear benchmarks of success, structuring regulations in the field of pollution control, increasing the commitment of decision-makers in government and society, and community participation in environmental impact control programs. On the other hand, the function of Central Java’s Environmental Impact Control Agency (Bapedalda) is to monitor the implementation of Environmental Feasibility Study (EFS), evaluate environmental impact control activities and EFS implementation in the region, provide recommendations for determining EFS approval, make efforts to inform EFS, carry out technical guidance and supervision of environmental impact control, restore the environmental quality of life and control pollution and environmental damage.
Legal Protection of Children as Victims in Restorative Justice Based on Justice Value
Authors: Lubis Muhammad Ansori , Yassid Muhammad , Rosani Zulkarnain Novi Juli
Published: November 2022

The research purpose of this study is to determine the causes of children becoming victims of criminal acts and the legal protection of children as victims of justice-based crimes. approach method using normative juridical, research results which state that the protection of human rights for children who are victims of crimes is regulated in law as a legal protection for the State's obligations to the Indonesian people in ensuring the implementation of fundamental rights. The process of protecting and upholding human rights is carried out based on the state ideology, namely Pancasila which prioritizes human values, respecting the human rights of every citizen, both adults and children
Protracted Ambivalence: The decolonisation and indigenising of contemporary branding in Aotearoa
Authors:   , Stables Joshua
Published: November 2022

Most New Zealanders are unaware, ignorant, or dismissive of why and how colonisation continues to happen today, and what the effects on society are (Kiddle, 2020). Decolonising design means recovering Indigenous wisdom from the onslaught of imperialism and outmoded colonial beliefs. Whilst there has been an influx in decolonisation material within the past five years as Aotearoa begins to face it’s colonial past, and the negative impacts of colonialism, it can be hard to actualise this information. This research recognises the similarities within design colonisation and contemporary branding through the experiences of designers from different experience levels within the design industry, from recent graduates to multinational designers. These experiences of design practitioners produce a framework that acts as a foundation to decolonise brand design in the future. This research speaks to cultural appropriation and calls for ways indigenise branding within Aotearoa. Through kaupapa Māori, this research challenges mainstream ways of knowing and being and centralises the needs and interests of Māori for every decision. The findings of this research will help new designers understand the implications of the colonised state of branding and, as a result, will influence how they work for a more inclusive, fair and restorative future.
La violencia intrafamiliar. Definición y consecuencias
Authors: Cevallos Cárdenas Karina Johana , Viteri Rojas Ana María , Valencia Cevallos Andy Smith , Rodríguez Jaramillo Maricela Del Carmen
Published: November 2022

Uno de los problemas principales del estudio de la violencia es la falta de una definición precisa que dé cuenta de la multiplicidad de formas en las que ésta se presenta o, cuando menos, señale sus características más importantes y comunes. Al analizar los efectos de la violencia sobre la salud de la mujer se obtiene que las expone a un mayor riesgo de enfermedades físicas y mentales por lo que aumenta el interés en estudiar algunos marcadores que orienten su confirmación diagnóstica. Con la investigación se pretende estudiar los resultados que abordan esta problemática desde distintos ámbitos promoviendo una mirada integral y multidisciplinaria sobre la violencia, fenómeno con múltiples implicaciones sociales y culturales que influyen a la aplicación de tales políticas y medidas de control sanitario y judicial en la República del Ecuador. es necesario no solo identificar y tener claro las formas en que se materializa la violencia entre las personas puesto que el desconocimiento teórico de la misma puede llevar a tener consecuencias graves en el desarrollo físico y psicológico del ser humano cuyo desenlace puede resultar desde una disfuncionalidad del adulto hasta la muerte, ya sea en mujeres gestantes, el feto o en el adulto deprimido. El marco legal reconoce la existencia de esta problemática, tanto así que los esfuerzos al legislar resultan en un conjunto de artículos y leyes que busca consecuencias judiciales para quien las cometa.
Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022
Authors: Day Michaela , Pitt Rachel , Mody Nisha , Saunders John , Rai Rupa , Nori Achyuta , Church Hannah , Mensforth Sarah , Corkin Helen , Jones Jacqueline , Naicker Preneshni , Khan Wazirzada M , Thomson Glover Rebecca , Mortimer Kalani , Hylton Chloe , Moss Elizabeth , Pasvol Thomas Joshua , Richardson Ania , Sun Suzy , Woodford Neil , Mohammed Hamish , Sinka Katy , Fifer Helen
Published: November 2022

Between December 2021 and June 2022, 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae (ST8123; n = 8) were detected in the United Kingdom, compared with nine cases during the previous 6 years. Most of these cases were associated with travel from the Asia-Pacific region; all were heterosexual people, with most in their 20s. Although all cases were successfully treated, not all partners of cases could be traced, and there is a risk of further transmission of ceftriaxone-resistant gonococcal infection within the UK.
Konseling Kelompok Rational Emotive Behavior Therapy (REBT) dengan Nilai Tafakkur untuk Meningkatkan Kecerdasan Emosional Remaja Putra Panti Asuhan Darul Ihsan Prambanan Yogyakarta
Authors: Hadi Syamsul
Published: November 2022

This research departs from cases of violence that are rife in adolescents' environment in the form of deviant behavior caused by low emotional intelligence. The purpose of this study was to test the effectiveness of the Rational Emotive Behavior Therapy (REBT) group counseling with the value of Tafakkur to Improve the Emotional Intelligence of the Boys at Darul Ihsan Prambanan Orphanage Yogyakarta. The subjects involved were 14 adolescents in the orphanage, who were then divided into two groups, 7 teenagers in the experimental group and 7 teenagers in the control group. This study uses a quasi-experimental design so that the results of the rational emotive behavior therapy (REBT) group counseling with tafakkur value are effective for improving the emotional intelligence of young men at the Darul Ihsan Muhammadiyah Prambanan Orphanage, where the Z value is -2.371 with a significance level of p = 0.018 which means 0.01 <p <0.05.
Pengembangan Modul Pengenalan Karir untuk Siswa MTs
Authors: Rajasa Pief Gustida Aji
Published: November 2022

One of the educational environments that play a major role in children's education from an early age is the family environment. Nowadays, the rapid development of technology makes many values ??and norms change, both positive and negative. These changes indirectly require parents to be able to adjust parenting patterns according to the demands of the times. 21st century thinking skills in this case become one of the skills that must be introduced to students from an early age. Responding to the increasingly complex challenges of authoritarian, permissive, and democratic parenting that may have been effective at that time, may no longer be relevant to use in the digital era as it is today. Referring to these conditions, this study aimed to analyze the role of millennial parenting on students' critical thinking skills. This study uses a library research method through qualitative research by reviewing the literature relevant to this topic. The results of the study show that the role of millennial parents' parenting has an impact on shaping 21st century thinking skills.
I want to celebrate as hymns acculturation of i will sing of my redeemer (an analysis on a Sangihe Masamper song)
Authors: Latuni Glenie
Published: November 2022

This research aims to analyze the acculturation process through the hymn I will sing of my Redeemer, which became Hymn MasamperI Want To Celebrate. I will use a qualitative approach to explore the perspective of ethnomusicology and hymnology through observation, interviews, and literature review. Observations have been made for a long time because the researcher is also the artist of Masamper Art. But the focus of observation from 2008 until now has been Observations were made on various Masamper performances in the Sangihe community in the Sangihe Islands and the Sangihe diaspora community on the mainland of North Sulawesi in the city of Manado. The results of the analysis found that the existence of the song "I want to be grateful," Masamper's singing in the Sangihe community, is the result of acculturation from the Hymn. songI will sing of my Redeemer works by Philip Paul Bliss. The results of this acculturation found that there was a change in form from a 3 stanza strophic form to a 1 stanza strophic form, but it is done repeatedly. The bars have also changed from 9/8 bars for the original song to bars for mourning (Masamper Sabuah) and 4/4 bars during party performances or competitions (Mebawalase). The tempo changes from fast to slow but uses stress on each word. Meanwhile, the meter still uses the 8.7.8.7 CM (Common Meter) pattern except for the refrain. The syllabic pattern, or singing with one note for one syllable, is still carried out, but new developments have emerged in the Sangihe community, namely the Manahola singing style, or singing before the main song word, the Mamaranca style of singing repeating words in the verse that are currently being sung, and the Yora style of singing while singing. Do word stresses on the refrain or repetition of the song, which is usually done while dancing.
Human resources management in developing learning strategies in the new normal era
Authors: Yuliaty Farida
Published: November 2022

The purpose of this study was to analyze human resource management in developing learning strategies in the New Normal era, because many learning during the pandemic was found to be ineffective and inefficient, so that students were confused. In this new normal, a human resource management strategy is needed that can be used to monitor. This research method uses a library research approach which is a research method to find and describe some appropriate and relevant research from the topic that the researcher will do. The results of this study indicate that during this pandemic various problems were experienced by various parties. So that HR management is needed to improve learning strategies in the new normal era, namely through efforts, mature readiness, and debriefing both in terms of ICT learning and virtual study habits.
Entrepreneurial commitment, entrepreneurial competence, towards business performance through business competitiveness development
Authors: Ahmad Tri Sulkarnain , Ahmad Srifatmawati , Afriyani Afriyani
Published: November 2022

Wajo Regency is the best silk weaving industrial area in South Sulawesi, but the emergence of several competitors for silk fabrics from abroad, and various modern-style fabric products that are variously supplied by wholesalers from outside the South Sulawesi area indirectly affect the movement of market. This study aims to determine the effect of entrepreneurial commitment, entrepreneurial competence and competitiveness of the silk industry on the business performance of silk entrepreneurs. The type of research is a quantitative research methodology. The research was conducted on a silk business located in Wajo Regency, South Sulawesi Province. A total of 357 samples were obtained using the cluster random sampling technique based on the Krejcie and Morgan tables. Data collection method employing a scale that uses the Likert scale. Data analysis techniques using the SmartPLS 3.0 software's path analysis, it was found that commitment, entrepreneurial competence has a significant effect on business performance, commitment has a significant effect on the development of competitiveness, and entrepreneurial competence has not significant effect on the development of competitiveness. The results found that the entrepreneurial competence of silk entrepreneurs was still lacking in developing the competitiveness of the silk business.