bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of key bioactive anti-migraine constituents of Asari radix et rhizoma using network pharmacology and nitroglycerin-induced migraine rat model
Authors: Huang Ting , Dai Zhong-Hua , Long Fei , Lei Yu-Tian , Yuan Mao-Hua , Jiang Gui-Hua
Published: February 2022

Purpose: To elucidate the bioactive constituents of Asari radix et rhizoma (ARR) in treating migraine based on network pharmacology and nitroglycerin-induced migraine rat model.

Methods: The potential bioactive constituents of ARR were identified with the aid of literature retrieval and virtual screening, and the migraine-related hub genes were identified using protein-protein interaction and topology analyses. Then, the interaction between the potential bioactive constituents and hub genes was determined with molecular docking and topology, leading to the prediction of the anti-migraine constituents of ARR. Moreover, a rat model of nitroglycerin-induced migraine was used to confirm the prediction by measuring the frequency of head-scratching and head-shaking behavior (FHHB) in the rats. In addition, levels of nitric oxide (NO) and calcitonin gene-related peptide (CGRP) in blood, norepinephrine (NE) and 5-hydroxytryptamine (5-HT) in brain were measured using appropriate commercial kits.

Results: Network pharmacology revealed that naringenin-7-O-β-D-glucopyranoside and higenamine might be the key anti-migraine bioactive constituents of ARR. On addition of naringenin-7-O-β-D- glucopyranoside or higenamine to ARR, there was marked enhancement of the mitigating effect of ARR on nitroglycerin-induced abnormalities in levels of NO, CGRP, 5-HT and NE, as well as FHHB in rats (p < 0.05 or 0.01).

Conclusion: These findings indicate that naringenin-7-O-β-D-glucopyranoside and higenamine might be the key bioactive and anti-migraine constituents of ARR. However, in addition to naringenin-7-O-β-D- glucopyranoside and higenamine, there were many other anti-migraine constituents in ARR. Therefore, there is need for further investigations on the actual contributions of these two constituents of ARR in treating migraine.
Vasodilating effect of Hypericum revolutum (Vahl) (Clusiaceae) methanol extract in rats
Authors: Timraz Noha Z. , El-Bassossy Hany M. , Ibrahim Sabrin R.M. , El- Halawany Ali M. , Shehata Brahim A. , Aljohani Omar S. , Abdallah Hossam M.
Published: February 2022

Purpose: To investigate the vasodilating effect of Hypericum revolutum Vahl (Clusiaceae) in rats.

Methods: H. revolutum aerial parts were extracted with methanol. The total methanol extract was fractionated with chloroform to yield fraction I. The remaining aqueous solution was chromatographed on Diaion HP-20 using water, 50 % methanol, and methanol to yield three fractions (II- IV). Total methanol extract and fractions I-IV were applied to phenylephrine-pre-contracted (10 μM) rat aortic rings at doses of 1, 3, and 10 μg/mL. Subsequent decreases in aortic tension were recorded by an isometric force transducer to evaluate the vasodilation. Column chromatography was utilized to separate the active components of the bioactive fraction.

Results: Remarkable decreases in aortic tension (p<0.05) revealed that fraction I (3 and 10 μg/mL) produced a vasodilating effect, whereas fractions III and IV did not possess any substantial effect. Vasodilation induced by fraction I was endothelial-dependent because it was significantly (p<0.05) blocked by endothelial denudation. Phytochemical inspection of fraction I led to the isolation of β- sitosterol (1), 1,7-dihydroxyxanthone (euxanthone) (2), and 2,3,4-tirmethoxy xanthone (3).

Conclusion: Fraction I of the H. revolutum extract was responsible for its vasodilating effect. This fraction may be used as a possible anti-hypertensive preparation after in vivo testing and successful clinical trials.
Evaluation of impact of pharmaceutical care services on cardiologist adherence to hypertension Guidelines JNC 7: A critical prospect for rational use of drugs in Pakistan
Authors: Akhtar Muhammad Massom , Waheed Akbar , Farooq Muhammad Shahid , Shamim Rahat , Batool Narjis , Hakeem Ammara , Nadeem Muhammad Umer , Saleem Zikria
Published: February 2022

Purpose: To assess the adherence of cardiologists to JNC7 and the impact of pharmacists in reducing clinical inertia by managing high blood pressure in the cardiology out-patient department of the Armed Forces Institute of Cardiology, Rawalpindi, Pakistan.

Methods: This was a pre- and post-interventional prospective study in which data was abstracted from patients’ history notes or prescription of selected patients at baseline and follow-up visits by applying a reliable tool. The data were abstracted again from the same patients to evaluate the cardiologists’ adherence with the same parameters after 2,4 and 6 months. The sample size for this study was 116 patients and descriptive statistics were used for categorical variables. For the comparison of cardiologist’s adherence to JNC7, means and paired ‘t’ test were used at the level of 0.05 significance.

Results: At baseline, the mean overall percentage of cardiologists’ adherence to JNC7 was 46.7 ± 18.9 %. This significantly improved to 98.8 ± 6.0 % after 2 months of the pharmacist intervening by way of discussions with cardiologists. The cardiologists’ adherence was further improved to 100 % after 4 and 6 months.

Conclusion: Improvement in cardiologists’ adherence to JNC 7 guidelines and involvement of the pharmacist enhance the documentation of BP goal, lifestyle modifications and uncontrolled BP. All these helps to overcome clinical inertia that ultimately leads to better BP control and rational use of medicines.
Comparison of the safety and clinical efficacy of glucagon-like peptide-1 receptor agonist and α-glucosidase inhibitor among Chinese people with type 2 diabetes
Authors: Hu Qinjin , Zhu Jingjing
Published: February 2022

Purpose: To compare the safety and efficacy of once-weekly prescription of GLP-1 receptor agonists (adlyxin) with those of α-glucosidase inhibitor (voglibose) and other reference drugs (RD).

Methods: A total of 1250 stable diabetes-mellitus patients from the Department of Endocrinology, Ningbo No. 6 Hospital, Ningbo, Zhejiang 315040, China were enrolled in this study between Feb 2018 and Jan 2020. They were treated using physical exercise and diet chart therapy. The patients were assigned to three different groups and administered GLP-1 receptor agonist (GLP-1RA) or glucosidase inhibitor (voglibose) and other reference drugs (RDs). The safety and efficacy of these drugs were compared. The primary endpoint was the number of treatment-emergent adverse events (TEAEs), while the secondary endpoints were based on symptomatic hypoglycaemic episodes and other biochemical parameters.

Results: Patients who used α-glucosidase inhibitors had the highest percentage of TEAEs, when compared to those on GLP-1RAs and RDs (p < 0.05). No specific cases of severe hypoglycaemia were observed among all the groups. Users of adlyxin also achieved significant glycaemic control at the end of the study period, when compared to voglibose users, with a mean HbA1c baseline of 8.2 % (p < 0.05).

Conclusion: These results indicate that the GLP-1 receptor agonist adlyxin achieved good glycaemic control. Thus, it has beneficial potential for use among type 2 diabetes in the Chinese population.
Mesoporous silica nanoparticles: Synthesis, functionalization, drug loading and release - A review
Authors: Galabova Bogdana B.
Published: February 2022

A brief survey on the synthesis of several types of mesoporous silica nanoparticles and their uses as drug delivery nanocarriers is presented in this study. Mesoporous silica nanoparticles (MSNs) have a small pore size, resulting in a large surface area and porosity. These characteristics are easily adjustable, conferring on MSNs advantages over other nanoparticles for use in medicine and pharmacy. Previous and latest trends in the technology of this type of nanoparticles, and the possibilities for their application in drug loading are considered, as well as methods for increasing drug loading capacity, functionalization and release of bioactive substances. It has been found that the method used for the synthesis of some types of MSNs results in better drug loading. The functionalization of nanoparticles not only allows for more successful loading of bioactive substances in its pores, it also successfully controls drug release. Moreover, these versatile nanoparticles enhance the solubility of poorly-soluble drugs, thereby overcoming one of the biggest problems in the absorption of these drugs.
Rhotekin 2 promotes progression of endometrial carcinoma by activating Akt/GSK3β signaling pathway
Authors: Hu Ting , Wang Min , Zeng Jing , Wang Xiaoli , Gu Hangzhi
Published: February 2022

Purpose: To investigate the expression of rhotekin 2 (RTKN2) in human endometrial carcinoma tissues and its role in cancer progression.

Methods: Quantitative polymerase chain reaction (qPCR) and immunoblot assays were performed to determine the expression of RTKN2 in endometrial carcinoma tissues and cells. The effects of RTKN2 on cell proliferation were assessed using cell counting kit-8 and EdU assays, while its effects on cell cycle and apoptosis in endometrial carcinoma cells were evaluated by flow cytometry. The involvement of RTKN2 in activating Akt/glycogen synthase kinase-3 beta (GSK3β) pathway was characterized using an immunoblot assay. Tumor growth assays were performed to assess the effects of RTKN2 on the progression of endometrial carcinoma in vivo, while protein expression in tumor tissues was determined by an immunohistochemical assay.

Results: High expression of RTKN2 was found in human endometrial carcinoma tissues and cell lines (p < 0.05). RTKN2 promoted the proliferation and cell cycle of endometrial carcinoma cells in vitro and suppressed apoptosis (p < 0.05). RTKN2 also activated Akt/GSK3β pathway in endometrial carcinoma cells and thus promoted tumor growth in vivo.

Conclusion: The involvement of RTKN2 in the progression of endometrial carcinoma has been confirmed in this study. RTKN2 is thus a promising therapeutic target for patients with this disease.
Ormosanine confers protection on neuronal function via regulation of inflammatory cytokine levels and oxidative stress
Authors: Liang Juping , Dong Jicun , Yang Yang
Published: February 2022

Purpose: To investigate the neuroprotective effect of ormosanine on rat model of Alzheimer’s disease (AD), and the mechanism(s) of action involved.

Methods: Rats were randomly assigned to 4 groups (10 rats/group): control group, AD group, 25 mg ormosanine/kg group, and 50 mg ormosanine/kg group. Alzheimer’s disease (AD) was induced in the rats via intracerebroventricular (ICV) injection of amyloid-β (Aβ)25-35 at a concentration of 1 mg/mL. Cognitive function was determined by Morris water maze test (MWMT), while lipid profile, oxidative stress parameters and cytokine level were assayed using their respective assay kits. The levels of monoamines were determined in brain tissues using high-performance liquid chromatography (HPLC), while terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay was used to determine apoptosis in neuronal cells.

Results: Cognitive function was significantly improved (p < 0.05) in ormosanine treated group than AD group of rats. Ormosanine significantly and dose-dependently reduced lipid and cytokines levels as well as activities of AST and ALT, but it significantly increased the level of HDL-C in a dose-dependent fashion (p < 0.05). Moreover, ormosanine significantly and dose-dependently increased SOD activity, but reduced MDA level and neuronal cell apoptosis in brain tissues of AD rats (p < 0.05). Treatment of AD rats with ormosanine led to significant and dose-dependent increase in the levels of monoamines and BDNF in rat brain tissues (p < 0.05).

Conclusion: These results show that ormosanine confers protection on neuronal function via regulation of inflammatory cytokine levels and oxidative stress, and therefore, could potentially be developed for the management of Alzheimer’s disease.
Modelling spillover effects of a marine protected area in the Western Indian Ocean
Authors: Sultan Riad M. A.
Published: February 2022

This study estimated the abundance gradient of fishes in the waters surrounding a marine protected area (MPA) and used this information as evidence of spillover from the MPA. Fish landing data were collected from trap fishermen over a 12-month period from the Blue Bay Marine Park on the west coast of Mauritius in the Western Indian Ocean. Two indicators of abundance were used: catch per trap, and number of fish per trap. A Generalised Linear Model was used to standardise the catch data by removing the effects of individual fishermen’s productivity from the abundance measurements while the negative-binomial distribution was used for the number of fish. The study found a slight declining gradient of catch beyond the MPA up to a distance of 4 km. The study also established that the individuals belonging to key species caught near the MPA were larger thanthose of the same species caught more than 4 km away. The negative gradient reinforces the evidence of spillover occurring from the MPA.
Seagrass restoration trials in tropical seagrass meadows of Kenya
Authors: Uku Jacqueline , Daudi Lillian , Muthama Charles , Alati Victor , Kimathi Alex , Ndirangu Samuel
Published: February 2022

The degradation of seagrasses is becoming prevalent in the Western Indian Ocean (WIO) region due to anchor damage, sea urchin herbivory, extreme events such as cyclones and floods and anthropogenic factors such as pollution and sediment inflows. Consequently, there have been numerous efforts to advance the restoration of degraded seagrass beds in several countries in the region. In Kenya, experimental restoration efforts were started in 2007 in response to seagrass habitat degradation due to sea urchin herbivory. Although the initial efforts experienced challenges, there were lessons learned which provided insights into subsequent restoration work using different techniques. In this paper, insights are provided into three types of restoration techniques; the sod technique, the seagrass mimic technique, and the Hessian bag technique. In the case of the sod technique, Thalassodendron ciliatum showed a decline from 20 ± 1.7 shoots sod-1 in the first three weeks to 7 ± 4.4 shoots sod-1 at the end of the experimental period of the study, while Thalassia hemprichii sods showed an increase from 28 ± 3.4 shoots sod-1 to 32 ± 2.7 shoots sod-1 over the same period. For the Hessian bag method, the expectation was that the pilot site would be filled with the transplanted seagrass species, Thalassia hemprichii, but the findings showed that different species including Halodule uninervis, Syringodium isoetifolium, Halophila stipulacea, Cymodocea rotundata, and Cymodocea serrulata colonized the area. This indicated that it was not possible to restore the area to its original status, but that the area could be rehabilitated. The costs of restoration have also been assessed as well as community participation in such initiatives. These findings provide insights for restoration efforts in Kenya and provide a baseline for future work.
The use of a constraints-led approach in elite netball coaching: understanding practical application.
Authors:   , Ruffell-Hazell Amy
Published: February 2022

Background: For more than two decades the Constraints-Led Approach has gathered considerable interest within coaching research, informing the decisions of sports coaching experts (Renshaw et al., 2019; Renshaw et al., 2012). However, there remains a lack of valid research on the effective implementation of the approach, with extensive gaps between theory and practice, in turn, this has halted its uptake by practitioners and has led to the misinterpretation and incorrect implementation of the approach (Renshaw et al., 2019; Clark et al., 2018). Purpose: The aim of this study was to investigate whether the Constraints-Led Approach is utilised by coaches within elite netball practice, to comprehend the degree to which coaches recognise this approach and to explore the facilitators and barriers faced in the implementation of this approach. Design: An interpretivist research design and qualitative research method inclusive of semi-structured interviews and session observations were used in this study. Three participants, representative of a full VNSL coaching staff set up, were selected through purposive expert sampling to be involved in this study. Findings: Data collected, identified three emergent themes; Understanding the Theoretical Underpinnings of a Constraints-Led Approach; Practitioner Experiences in Linking Theory to Practice, Ensuring a Representative Learning Design and Designing an Environment Suitable for the Implementation of a Constraints-Led Approach. Conclusions: Results imply that if practitioners can understand, apply and appropriately balance these three themes then a Constraints-Led Approach can be successfully applied. Consequently, a Constraints-Led Approach can be implemented successfully and fully embedded by practitioners within an elite netball context. Significance: This study provides a significant contribution to research as the successful implementation of this approach remains largely unexplored with no extensive study conducted within elite netball practice. These findings contribute depth and richness to academic work and should encourage practitioners to effect change in their own coaching practice.
Prevalence and roles of vice-chairs in schools and colleges of pharmacy
Authors: Yamzon Joycelyn , Pham David Q , Hess Karl
Published: February 2022

Introduction: The activities and roles of vice-chairs (VC) in academic medicine are described in the literature but are not presently known in academic pharmacy.   
Aim: The objectives of this pilot study were to determine the prevalence of VC, describe the roles and responsibilities of VC in various departments, and evaluate why some institutions may not have VC.   
Methods: A Qualtrics survey was sent to all pharmacy school Deans from October to November 2018. Survey results were analysed using qualitative and quantitative methods.   
Results: Based on the 49.6% response rate, the overall prevalence of VC was estimated to be 41%. The primary reason for VC was to support the department chair and responsibilities included faculty mentorship, development, and evaluations. Fifty-five per cent of those without VC stated the position was not perceived as needed.   
Conclusion: VC are not widely utilised by pharmacy schools. For institutions considering VC, they may help offset the department chair’s workload.
Recommendations for implementing work-integrated learning in South African schools of pharmacy
Authors: Kotzé Irma , Reitsma Gerda , Botha René
Published: February 2022

Aim: Pharmacy schools in South Africa need to prove compliance with work-integrated learning (WIL) as articulated in the Good Pharmacy Education Standards (GPES). This study aims to determine the current status of WIL in South African schools of pharmacy.    
Method: Semi-structured interviews were conducted with heads of pharmacy schools regarding the challenges experienced with the implementation of WIL.    
Results: Four of the possible nine heads of South African schools of pharmacy participated in the study. Categories and subcategories were identified under the theme ‘challenges of WIL’.    
Conclusion: Findings showed that pharmacy schools in South Africa comply partially with WIL requirements. Possible reasons for partial compliance are challenges experienced relating to resources, campus-based infrastructure and service providers. Based on this study’s findings, the authors present several recommendations for the implementation of WIL in South African pharmacy schools.
Interdisciplinaridade e rodas de conhecimento: o papel das bacias hidrográficas e seus fundamentos epistemológicos dentro das geociências agrárias e ambientais
Authors: Camargo Pedro Luiz Teixeira de , Martins Júnior Paulo Pereira , Beserra Raphaella Karla Portes
Published: February 2022

Não é comum nas Ciências da Natureza o debate acerca de problemas filosóficos de definição. Em geral busca-se apenas o trabalho concreto de uma determinada pesquisa sem se preocupar ao que levou a isto. Desta forma, os conceitos de interdisciplinaridade, de rodas de conhecimento e as definições epistemológicas de termos utilizados em trabalho sobre bacias hidrográficas pouco são falados, ficando muitas vezes deixados de lado. O objetivo deste trabalho, portanto, é esse: baseado nos estudos de Martins Jr (1998, 2014a e b) explicar epistemologicamente os termos usados em estudos de bacias hidrográficas através da compreensão do que vem a ser interdisciplinaridade. Pode-se concluir que as bacias hidrográficas precisam, de fato, de uma linha de pesquisa específica, mas como estudos filosóficos e teóricos dentro das Ciências Exatas e da Terra são ainda raros, em especial no campo da gnosiologia, só agora foi apresentada, de fato uma proposta real de subárea capaz de englobar esta temática, mostrando ser importante o incentivo a mais estudos como este aqui presente.
Evaluation Of Physical Activity, Sleep Quality And Time Management Skills Of Physiotherapy And Rehabilitation Students During The Covid-19 Pandemic Process
Authors: ALACA Nuray , Yıldız Aydanur , Zeytin Yaren , Karaca Melih , Dilek Burcu
Published: February 2022

Introduction: In our study, it is aimed to evaluate the physical activities, sleep quality and time management skills of the students studying in the Physiotherapy and Rehabilitation (PTR) Department, which is a department with intensive theoretical and practical course hours during the COVID-19 process. Method: All PTR students (n= 311, 75.56% female n= 265, 24.44% male n= 76) who met the inclusion criteria International Physical Activity Questionnaire (IPAQ) was used to determine physical activity level, Pittsburgh Sleep Quality Index (PSQI) was used to determine sleep quality, and Time Management Inventory (TMI) was used to determine time management skill. Results: During the COVID-19 pandemic of the students in the PTR department, 72.48% had poor sleep quality, 27.43% were inactive and only 22.82% had sufficient physical activity. Female students body mass indexes were lower, physical activity levels, time attitudes (managing time well) and sleep quality were negatively affected, and the time they spent sitting was found to be higher than men (p<0.05). The use of sleeping pills, sleep quality total score, time management and attitudes had a worse affect in inactive students than students with adequate physical activity (p<0.05). In addition, students with good physical activity scores were found to have less use of sleeping pills and a weak level of positive correlation with time management (p<0.05). It was also found that some of the subscales of sleep disorders a weak level of negatively correlated with some scores of time management (p<0.05). Discussion and Conclusion: In our study, it was observed that the physical activities and sleep quality of the students in the PTR department were negatively affected during the COVID-19 pandemic, while this situation was more dominant in female students. In addition, students with poor time management skills were found to have low physical activity levels and poor sleep quality. However, more studies are needed, especially on the effects and education of time management.
Validity And Reliability Of The COVID-19 Vaccine Perception And Attitude Scale
Authors: eriş Hüseyin
Published: February 2022

A virus detected in Wuhan, China on December 29, 2019, was named covid-19 and declared a pandemic by the world health organization on March 11, 2020, due to the destruction caused by this virus.Due to the lack of any treatment method for the new virus, many countries and pharmaceutical companies have started to develop vaccines against this virus. Although rapidly developed vaccines have been put into practice worldwide, some individuals objected to being vaccinated for reasons such as vaccine hesitancy or anti-vaccination. Some of the individuals in Turkey are also indecisive about vaccines and therefore do not want to be vaccinated. The purpose of this research is to develop a scale with proven validity and reliability to measure the perceptions and attitudes of individuals aged 18 and over living in Turkey towards Covid-19 vaccines. For this purpose, the covid-19 vaccine perception and attitude scale, which consists of 21 expressions and 2 sub-dimensions, was transferred to the electronic environment and applied to 291 people in Turkey between 15.09.2021 and 16.09.2021. The reliability values of both sub-dimensions of the scale used in the research were high. According to the Bartlett test performed, it is appropriate and necessary to perform factor analysis on the items in the scale, the sample size is sufficient in terms of representing the universe in the research for factor analysis of the KMO coefficient, and the high factor loads of the items in the scale show that it is important for the scale to which the items belong. As a result, it has been determined that this developed scale is a valid measurement tool to determine the covid-19 vaccine perceptions and attitudes of people aged 18 and over, according to the results of the analysis, and its reliability is also high.
Koncept energetske sigurnosti u suvremenim sigurnosnim studijama
Authors: Radić Đozić Jelena
Published: February 2022

Sintagma energetska sigurnost toliko je često korištena da se čini jasnom i razumljivom. To je samo privid, jer je njezina upotreba ustvari kontroverzna, često i preholistička, što upućuje na nedovoljnu razvijenost koncepta. Pod pojmom energetske sigurnosti raspravlja se o najrazličitijim pitanjima, koje na okupu drži pojam „energija” kao zajednički nazivnik. U ovome se radu polazi od toga da je aktualni rast važnosti koncepta posljedica nove uloge koju je plinska trgovina između EU-a i RF-a dobila nakon 2000., kao svojevrsna eksternalija njezina korištenja u politici moći, njezine politizacije i pokušaja sekuritizacije. Pokazat će se da je koncept uvriježen semantički konstrukt, no analitički prazan – pokriven je sektorom ekonomske, još više (vanjsko)političke sigurnosti. Razjašnjenje i redefiniranje koncepta energetske sigurnosti u aktualnom kontekstu pridonosi boljem teorijskom definiranju i dubljem razumijevanju empirijskih posljedica korištenja koncepta, koji već kao diskurzivna praksa određuje što se smatra problemom i može otežati ekonomsku suradnju.
Utjecaj njemačkoga pitanja na nastanak europskih integracija iz konstruktivističke perspektive Alexandera Wendta
Authors: Biškup Mašanović Ljiljana
Published: February 2022

U radu se, korištenjem konstruktivističkog pristupa Alexandera Wendta, analiziraju razlozi za nastanak europskih integracija s obzirom na
neriješeno njemačko pitanje. Pritom se koristi model odnosa identiteta i
interesa kako bi se analiziralo ponašanje Sjedinjenih Američkih Država
i Sovjetskoga Saveza u razdoblju od 1945. do 1990. s obzirom na nastanak hladnoga rata, europskih integracija i rješavanje njemačkoga pitanja.
Također se analizira odnos identiteta i interesa dviju njemačkih država
prema njihovom budućem ujedinjenju. Polazeći od Giddensove teorije
strukturacije, na koju se naslanja Wendtov konstruktivizam, prati se ponašanje države kao agenta u odnosu prema anarhiji kao strukturi među‑
narodnog sustava. U članku se propituje pretpostavka da je neriješeno
njemačko pitanje ubrzalo, ali i uvjetovalo nastanak europskih integracija.
Na kraju članka analizira se utjecaj politike detanta i njezinih posljedica
na njemačko ujedinjenje.
ENSINO DE GEOGRAFIA:
Authors: Martins Fernanda Pereira , Cury Raquel Balli
Published: February 2022

Este artigo é produto de um conjunto de reflexões realizadas em turmas de 8º e 9º ano do ensino fundamental em uma escola da rede particular de ensino em Ituiutaba/MG. Ao compreender que o uso adequado de conceitos é condição sine qua non para a leitura da realidade e transformação da mesma, procurou-se analisar e identificar como os educandos percebem um conceito no ensino de Geografia: o de Paisagem. Para tanto, foi executado um questionário e, posteriormente, uma roda de conversa para discutir o conceito paisagem e compreender a percepção dos discentes sobre essa categoria. Observou-se que nas atividades diagnósticas os alunos descreveram a paisagem representada pela imagem escolhida, identificando os elementos visíveis enfatizando aquilo que lhes parecia ser natural, excluindo o antropizado. Pode-se inferir com o estudo que é preciso uma prática docente alicerçada em metodologias que oportunizem a apreensão dos conceitos geográficos de forma efetiva, levando os alunos a questionar, problematizar e intervir na realidade vivida, oportunizando a construção dos conceitos, das categorias geográficas de análise de forma significativa, ampliando a percepção do aluno acerca do contexto em que está inserido. 

Palavras-chave

Educação, Geografia, Categoria, Paisagem.

 

GEOGRAPHY EDUCATION: student’s perception of the landscape analysis category

Abstract

This article is the product of a set of reflections made in 8th and 9th grade classes of elementary school in the private school system in Ituiutaba/MG. Understanding that the proper use of concepts is a sine qua non condition for reading and transforming the reality, we tried to analyze and identify how students perceive a specific concept, that of landscape. To this, a questionnaire was carried out and, subsequently, a conversation circle to discuss the landscape concept and understand their perception of this category. It was observed that in the diagnostic activities, students described a landscape represented by the chosen image, identifying the elements emphasizing what seemed to be natural, excluding the anthropized. It can be inferred from the study that a teaching practice based on methodologies that provide opportunities for the apprehension of geographical concepts in an effective way is necessary, leading students to question, problematize and intervene in the lived reality, providing opportunities for the construction of concepts, of the geographical categories of analysis significantly, expanding the student's perception of the context in which they are inserted.

Keywords

Education, Geography, Landscape, Category.
PENGARUH KOMPENSASI DAN KEPUASAN KERJA TERHADAP KINERJA KARYAWAN PRODUKSI DI PT. BUANA TUNAS SEJAHTERA
Authors: Cristian Dimas Priyo , Sesario R , Sutignya T.C.W.A
Published: February 2022

Compensation and job satisfaction are factors that affect employee performance in achieving a company's  goals. Employee performance is one of the factors that influence a company's success rate. This study aims to determine the effect of compensation and job satisfaction on the performance of production employees at PT. Buana Tunas Sejahtera. The purpose of this study was to discover the effect of compensation and job satisfaction on the performance of PT. Buana Tunas Sejahtera Seriang Mill located in Kapuas Hulu Regency, Badau District. The Multiple Linear Regression uses Analysis with a sample of 30 respondents production employees. Research analysis tool is a questionnaire with a Likert scale using SPSS version 22. The results in this compensation study did not affect employee performance with negative t test results, then job satisfaction had a significant effect on employee performance with positive T test results. Compensation and job satisfaction together have a significant positive effect on employee performance.
EFEKTIVITAS APLIKASI BIOCHAR TEMPURUNG KELAPA PADA MEDIA TANAM TERHADAP PERTUMBUHAN DAN SERAPAN HARA N DI PEMBIBITAN UTAMA KELAPA SAWIT (Elaeis guineensis Jacq.)
Authors: Tarigan Sri Murti , Aznur Tifany Zia , Umami Rafika
Published: February 2022

This study was conducted to determine the effect of application of coconut shell biochar on planting media on the growth and uptake of leaf and soil nutrients in oil palm main nurseries. To get good and healthy seeds, soil conditioner is also needed to increase land productivity. One of the soil improvement materials is biochar. This research was conducted in the STIPAP Medan experimental garden. This research was conducted for 6 months. Starting in August 2020 - February 2021. This study used a Factorial Randomized Block Design (RAK) method consisting of 9 treatments with 4 replications, so the total sample was 36 seedlings. Parameters observed were seedling height, stem diameter, number of leaves, shoot dry weight, root dry weight and nutrient N content in leaves and soil. The data obtained were analyzed statistically by analysis of variance (ANOVA) with the F test. The results of this study indicate that the application of coconut shell biochar and compound fertilizer in oil palm nurseries can use the best combination dose of 1.8 kg of biochar and 75% compound fertilizer of the dose. The standard gave several significant and very significant effects on stem height, stem diameter, number of leaves, shoot dry weight and root dry weight. And the interaction of coconut shell biochar treatment and compound fertilizer did not significantly affect all observation parameters.
POTENSI LIMBAH PADAT KELAPA SAWIT: PELEPAH KELAPA SAWIT DAN TANDAN KOSONG KELAPA SAWIT SEBAGAI BAHAN BAKU BIOETANOL
Authors: Simanjuntak Akladius L. Sani , Rangkuti Ika Ucha Pradifta , Ginting Muhammad Hendra
Published: February 2022

The global oil energy crisis is caused by the imbalance between consumption and production of petroleum. In order to compensate for this imbalance, the conversion of organic waste and biomass into fuel is carried out appropriately and quickly. This review article aims to determine the potential for solid waste from oil palm, Oil Palm Empty Bunches (TKKS) and Palm Oil Palm Ribs (PKS) as raw materials for making bioethanol. The production process of ethanol from palm oil solid waste is carried out starting from lignocellulosic pretreatment using alkaline and oxidation methods, with the highest results getting a decrease in lignin content in the EFB substrate from 35.51% to 9.47% or a decrease of 73.33%, while cellulose and hemicellulose content increased by 69% and 20.68% respectively, then the hydrolysis process with acid and enzyme catalysts with the highest yield obtained glucose levels of 60.02%, followed by a fermentation process using Saccharomyces Cerevisiae with the highest yield of ethanol content of 7.93%. Utilization of empty oil palm fruit bunches (TKKS) and oil palm midribs (PKS) as raw materials for the manufacture of bioethanol has enormous potential.
ESTRATEGIAS PARA EL DESARROLLO DE INNOVACIONES EDUCATIVAS BASADAS EN LA UTILIZACIÓN DE RECURSOS TECNOLÓGICOS
Authors: Vera Velázquez Raquel , Alcívar Cobeña José Luís , Castro Piguave Carlos Alberto , Narváez Campana Washington
Published: February 2022

La investigación fue realizada en la Universidad Estatal del Sur de Manabí en la carrera de ingeniería agropecuaria en el marco del seminario científico metodológico del periodo académico PI 2021 con el objetivo de identificar y presentar las estrategias generales para el desarrollo de innovaciones educativas basadas en la utilización de las Tecnologías de Información y Comunicación, a partir de las experiencias docentes reportadas por los participantes de las distintas materias de la carrera Agropecuaria, donde se realizaron revisiones bibliográficas de diferentes artículos, revistas, libros ponencias y experiencias de los docentes de las diferentes asignaturas, utilizando el método de revisión bibliográfica, análisis y síntesis y las técnicas de encuestas y debates. Analizando los nuevos entornos de aprendizaje con variados recursos tecnológicos y el perfeccionamiento en los modelos educativos. Estos entornos en general, proveen las herramientas y recursos tecnológicos necesarios para el desarrollo de una propuesta educativa basada en el uso de los mismos. Los recursos más comunes que es posible encontrar son: herramientas de comunicación o mensajería, foros, herramientas de gestión de evaluación y autoevaluación de aprendizajes, sistematización de contenidos, videoconferencias y chat, entre otras. Brindan además a los docentes la posibilidad de realizar seguimientos específicos de los estudiantes que participan en la propuesta y la disponibilidad de distintos tipos de estadísticas sobre el desarrollo del contenido. Su principal ventaja es la capacidad de dar seguimiento a los estudiantes, el registro de sus trabajos, aplicación de pruebas en línea, almacenamiento de portafolios electrónicos de trabajo y registro de sus evaluaciones.
IDENTIFICACIÓN DE PROPIEDADES DEL SUELO AGRÍCOLA EN LA PARROQUIA CHARAPOTÓ
Authors: Plúas Ponce María Fernanda , Ayón Villao Fernando , Morán Morán Jessica , Valdés Tamayo Pedro , Merchán García William
Published: February 2022

El proyecto integrador del saber se refiere a la identificación de las propiedades del suelo agrícola de la parroquia Charapotó, este proyecto se realizó en la carrera Agropecuaria en el primer semestre con el fin de integrar las ciencias básicas y las agropecuarias para preparar a los estudiantes en el perfil agropecuario y cada materia aporta al proyecto contenidos importantes para lograr las relaciones interdisciplinarias entre las asignaturas, donde el estudiante va a adquirir conocimientos referentes a las propiedades físicas y químicas que poseen los suelos agrícolas y su importancia. El objetivo del trabajo es identificar las propiedades físicas y químicas de los suelos agrícolas de la parroquia. Una vez realizado el estudio, tenemos que se destaca por tener un cuidado en sus suelos y sus productos como (arroz, maíz, cereal) además sus condiciones climatológicas son adecuadas para la efectividad y productividad de sus cultivos y cuidado de animales. La actividad económica de la parroquia es la agricultura y ganadería, donde el 49,22% de la población vinculada a la producción, el valle se siembra todo el año porque existe el sistema de canales y ríos; mientras en la zona montañosa solo se siembra una vez al año. Las principales actividades de la población están ubicadas en la parte de los balnearios de San Jacinto y San Clemente, su economía se basa en la pesca, extracción de sal, el turismo, el comercio y la artesanía, entre ellas las atarrayas y las de objetos de conchas y caracoles en menor escala.
COMPOSICIÓN ORGÁNICA DE LOS ALIMENTOS QUE GARANTIZAN LA SOBERANIA ALIMENTARIA EN LA PARROQUIA SAN JACINTO DEL BÚA
Authors: Chiquito Sornoza María Mercedes , Vera Velázquez Raquel , Del Valle Holguín Wilfrido , Vera Tumbaco Máximo , Orlando Indacochea Néstor
Published: February 2022

El proyecto se desarrolló en la parroquia San Jacinto del Búa de la provincia Santo Domingo, elaborado por los estudiantes de segundo semestre de la carrera de ingeniería Agropecuaria en el primer semestre del año 2020, realizado como proyecto integrador de saberes establecido en cada semestre en la carrera, donde todas las materias aportan al desarrollo de la investigación. El objetivo del trabajo fue identificar la composición orgánica de los alimentos que garantizan la soberanía alimenticia en la parroquia San Jacinto del Búa de la provincia Santo Domingo. Este proyecto es de origen cualitativo, investigativo, estadístico y descriptivo, el cual interviene de manera importante en la formación de los estudiantes, con él se busca determinar las propiedades, las características más importantes de la comunidad objeto de estudio. San Jacinto del Búa cuenta con 16 mil habitantes, se puede observar que este cantón tiene un suelo fértil, lo que permite cultivar una infinidad de productos, como el cacao, plátano, maíz y café los que aportan 5 elementos esenciales a la dieta humana carbohidratos, lípidos, vitaminas y minerales. Además, los resultados indican que es gran productor y consumidor de carne de res, pollo, pescado, etc., que aportan proteínas, aminoácidos y minerales al organismo humano. La gastronomía de la parroquia es muy variada, ya que sus habitantes son provenientes de diferentes lugares del país, por lo que sus platos típicos son caldo de gallina criolla, ceviche, guanta, bollo, tamales, viche de pescado y las comidas hechas con verde ya que es uno de los principales productos de la zona.
Pengaruh Tata Letak Produksi Terhadap Efisiensi Usaha dan Daya Saing UD. Barokah Lamongan
Authors: Handayani Wiwik , Hilmansyah Ival Abdi
Published: February 2022

This study aims to determine the effect of a number of factors that influence the provision of going concern audit opinions on manufacturing companies on the Indonesia Stock Exchange. In this study, the factors that are thought to influence the provision of going concern audit opinions consist of audit tenure, opinion shopping, audit delay and financial distress. The data analysis method used is binary logistic regression. Based on the results of hypothesis testing, it was found that audit tenure and opinion shopping had no significant effect on going concern audit opinions on manufacturing companies on the Indonesia Stock Exchange, while audit delay and financial distress had a significant effect on going concern audit opinions on manufacturing companies on the Indonesia Stock Exchange.

ABSTRAK

Penelitian ini bertujuan mengetahui pengaruh sejumlah faktor yang mempengaruhi pemberian opini audit going concern pada perusahaan manufaktur di Bursa Efek Indonesia. Pada penelitian ini faktor yang diduga mepengaruhi pemberian opini audit going concern terdiri dari audit tenure, opinion shoping, audit delay dan financial distress. Metode analisis data yang digunakan adalah regresi binary logistic. Berdasarkan hasil pengujian hipotesis ditemukan audit tenure dan opinion shoping tidak berpengaruh signifikan terhadap opini audit going concern pada perusahaan manufaktur di Bursa Efek Indonesia, sedangkan audit delay dan financial distress berpengaruh signifikan terhadap opini audit going concern pada perusahaan manufaktur di Bursa Efek Indonesia.
The Effect Of Special Allocation Funds, Profit Sharing Funds And Rest Of Budget Calculations On Capital Expenditures In District And City Governments In West Sumatra Province
Authors: Ananda Febryandhie , Hariani Dewi
Published: February 2022

ABSTRACT

The purpose of the study was to determine the effect of special allocation funds, profit-sharing funds and the remainder of the budget calculation on capital expenditures (study on Regency and City Governments in West Sumatra Province). This type of research is quantitative research. The scale used is the ratio measurement scale. The data used is time series data analysis. Source of data in the form of secondary data. The population is 19 regencies and cities in West Sumatra Province, which consists of 12 regencies and 7 cities for the 2014-2019 period. The sampling technique used was saturated sampling. Data collection technique is documentation. The data analysis technique is multiple linear regression analysis. Based on the results of the research that has been done, it can be concluded that the DAK has a significant positive effect on capital expenditures so that the hypothesis is accepted. DBH has a significant positive effect on capital expenditure so that the hypothesis is accepted. SILPA has no significant effect on capital expenditure so that hypothesis is rejected. DAK, DBH and SILPA together have a significant positive effect on capital expenditures. The adjusted R square value is 0.668, this means 66.8% of capital expenditure in 19 regencies and cities in West Sumatra Province which can be explained by special allocation funds (DAK), profit sharing funds (DBH) and excess budget calculations (SILPA). ) while the remaining 33.2% is explained by other factors not examined in this study.
Faktor Faktor yang Mempengaruhi Opini Audit Going Concern Pada Perusahaan Manufaktur di Bursa Efek Indonesia
Authors: Saputra Syailendra Eka , Syahrul Alfattory Rheza , Harini Gustia
Published: February 2022

This study aims to determine the effect of a number of factors that influence the provision of going concern audit opinions on manufacturing companies on the Indonesia Stock Exchange. In this study, the factors that are thought to influence the provision of going concern audit opinions consist of audit tenure, opinion shopping, audit delay and financial distress. The data analysis method used is binary logistic regression. Based on the results of hypothesis testing, it was found that audit tenure and opinion shopping had no significant effect on going concern audit opinions on manufacturing companies on the Indonesia Stock Exchange, while audit delay and financial distress had a significant effect on going concern audit opinions on manufacturing companies on the Indonesia Stock Exchange.

ABSTRAK

Penelitian ini bertujuan mengetahui pengaruh sejumlah faktor yang mempengaruhi pemberian opini audit going concern pada perusahaan manufaktur di Bursa Efek Indonesia. Pada penelitian ini faktor yang diduga mepengaruhi pemberian opini audit going concern terdiri dari audit tenure, opinion shoping, audit delay dan financial distress. Metode analisis data yang digunakan adalah regresi binary logistic. Berdasarkan hasil pengujian hipotesis ditemukan audit tenure dan opinion shoping tidak berpengaruh signifikan terhadap opini audit going concern pada perusahaan manufaktur di Bursa Efek Indonesia, sedangkan audit delay dan financial distress berpengaruh signifikan terhadap opini audit going concern pada perusahaan manufaktur di Bursa Efek Indonesia.
Determinan Kepuasan Pengguna E-Filing Masa Pandemi Covid-19
Authors: Aji Ridho Pramana , Puti Adriyanti Agustina , Sari Dian Puji Puspita
Published: February 2022

E-filing is a facility provided by the Direktorat Jendral Pajak (DJP) to report tax resposibility. The advantage of e-filing is that taxpayers can report their tax return (SPT) without being limited by distance, time and place. This fits perfectly with the COVID-19 pandemic situation, which requires us to limit face-to-face interactions. This study aims to evaluate the effect of information quality, system quality, and service quality on e-filing user satisfaction during the Covid-19 pandemic. This research was conducted using a survey method by distributing online and offline questionnaires to individual taxpayers who use e-filing registered at the Pekanbaru Senapelan Tax Service Office. The sample was selected using purposive sampling technique so that the sample obtained was 100 respondents. Hypothesis testing in this study used multiple linear regression analysis. The results of this study indicate that information quality and system quality have a positive effect on e-filing user satisfaction. Service quality has no effect on efiling user satisfaction.

ABSTRAK

E-filing merupakan sarana kemudahan yang disediakan Direktorat Jendral Pajak (DJP) untuk melaporkan kewajiban perpajakan. Keunggulan e-filing adalah wajib pajak dapat melaporkan Surat Pemberitahuan (SPT) tanpa dibatasi jarak, waktu dan tempat. Hal ini sangat cocok dengan situasi pandemi covid-19 yang mengharuskan kita membatasi interaksi tatap muka. Penelitian ini bertujuan untuk mengevaluasi pengaruh kualitas informasi, kualitas sistem, dan kualitas layanan terhadap kepuasan pengguna e-filing pada masa pandemi Covid-19. Penelitian ini dilakukan dengan metode survei dengan menyebarkan kuesioner secara online dan offline kepada wajib pajak orang pribadi yang menggunakan e-filing yang terdaftar di Kantor Pelayanan Pajak (KPP) Pekanbaru Senapelan. Sampel dipilih dengan menggunakan teknik purposive sampling sehingga sampel yang diperoleh sebanyak 100 responden. Pengujian hipotesis dalam penelitian ini menggunakan analisis regresi linier berganda. Hasil penelitian ini menunjukan bahwa kualitas informasi dan kualitas sistem berpengaruh positif terhadap kepuasan pengguna e-filing. Kualitas layanan tidak berpengaruh terhadap kepuasan pengguna  efiling.