bluuebunny/crossref_metadata_2025 huggingface dataset:
Maximizing the Response of a Helium Atom at the Third Harmonic of an Intense Femtosecond Ultraviolet Pulse
Authors: Khairulin Ilias R. , Emelin Mikhail Yu. , Popova Maria M. , Gryzlova Elena V. , Ryabikin Mikhail Yu. , Antonov Vladimir A.
Published: October 2023

The optimal regime of three-photon resonant excitation of a helium atom by a femtosecond ul-traviolet (UV) pulse was discovered and numerically studied, at which the maximum power of the third harmonic of the UV field is achieved in the spectrum of dipole acceleration (the second time derivative of the induced dipole moment) of the atom. It is shown that the optimal frequency of the UV field nearly coincides with the frequency of the three-photon transition 1s2 – 1s2p, taking into account its shift as a result of the dynamic Stark effect, and the intensity of the UV field is dictated by the condition of maximizing the product of the populations of the 1s2 and 1s2p states, averaged over the time interval during which the UV field is non-zero. For the considered UV field durations, from 10 to 100 cycles of the carrier frequency (from units to tens of femtoseconds), the optimal intensity lies in the range from 10^14 W/cm^2 to several units of 10^14 W/cm^2. It is shown that with an optimal choice of the frequency and intensity of the UV field, the dynamics of excitation of bound and continuum states, as well as the shape of the time envelope of the dipole acceleration of the atom, weakly depend on the duration of the UV field envelope; only their time scale changes significantly. In addition, under the optimal conditions the average power of the third harmonic signal in the dipole acceleration spectrum is practically independent of the duration of the UV field envelope.
Evaluating Influencing Factors of Visitor Experience in Offline Art Exhibitions
Authors: Cheng Lin , Xu Junping , Pan Younghwan
Published: October 2023

Art organizations are increasingly focusing on enhancing the visitor experience to attract a wider audience. The aim objective of this study was to explore the key factors that influence the visitor experience of offline art exhibitions and to use a mixed methods to data collection and analysis. The research process was divided into three stages. In the first stage, we conducted semi-structured interviews with 12 respondents by dividing the exhibition experience into three time periods: pre, during, and post-visit. We extracted seven factors affecting visitor experience through qualitative content analysis including marketing, motivation, physical environment, exhibit quality, participation, technology and service facilities; in the second stage, we developed an assessment scale and pretested it; in the third stage, we collected 725 questionnaires to validate the factors of visitor experience in art exhibitions. The results of linear regression analyses showed that all seven key factors had a significant impact on visitor experience. This study constructed a scale to assess the factors of art exhibition experience, which provides theoretical sup-port for in-depth study of art exhibition experience and useful guidance for planning and design-ing art exhibitions to improve the quality of visitors' experience of art exhibitions.
Role of Transjugular Intrahepatic Portosystemic Shunt in the Liver Transplant Setting
Authors: Di Cola Simone , Lapenna Lucia , Gazda Jakub , Fonte Stefano , Cusi Giulia , Esposito Samuele , Mattana Marco , Merli Manuela
Published: October 2023

Liver transplantation is currently the only curative therapy for patients with liver cirrhosis. Not all patients in the natural course of the disease will undergo transplantation, but the majority of them will experience portal hypertension and its complications. In addition to medical and endoscopic therapy, a key role in managing these complications is played by the placement of a transjugular intrahepatic portosystemic shunt (TIPS). Some indications for TIPS placement are well-established and they are expanding and broadening over time. This review aims to describe the role of TIPS in managing patients with liver cirrhosis, considering them as potential candidates for liver transplantation. As far as is known TIPS placement seems not to affect the surgical aspects of liver transplantation, in terms of intra operative bleeding rates, postoperative complications or length of stay in the Intensive Care Unit. However, the placement of a TIPS “towards transplant" can offer advantages in terms of enhancing the patient's clinical condition at the time of transplantation and improving patient survival. Additionally, the TIPS procedure can help preserve the technical feasibility of the transplant itself. In this context, indications for TIPS placement may be expanded and considered at an earlier stage. TIPS insertion can also lead to serious adverse events and there are no evidence-based recommendations on this topic to date. For these reasons further studies are needed to make reliable recommendations for TIPS in the pre-transplant setting.
A Global Resource Scheduling for Distributed Edge Computing
Authors: Tan Aiping , Li Yunuo , Wang Yan , Yang Yujie
Published: October 2023

Recently, there has been a growing interest in distributed edge computing resource scheduling. For example, application scenarios such as intelligent traffic systems and Internet of Things(IoT) intelligent monitoring require the scheduling and migration of distributed resources. Distributed resource scheduling needs to consider the cost of resource scheduling, with the primary goal of finding the optimal strategy among various feasible solutions. There are different definitions for optimization objectives in different application scenarios, such as cost, transmission delay, energy consumption, etc. Current research mainly considers the optimization problem of local resource scheduling but needs more consideration of global resource scheduling. This paper defines a global resource scheduling problem for distributed edge computing and proves that the problem is NP-Hard. A heuristic solution strategy based on the Ant Colony Algorithm(ACO) was proposed, and Particle Swarm Optimization(PSO) was used to optimize the parameters of the ACO. Finally, an experimental comparative analysis was conducted to demonstrate that the algorithm proposed in this paper has good accuracy and iteration cost performance.
Comparative Study on the Thermal Properties of Engine Oils and Their Nanofluids Incorporating Fullerene-C60, TiO2, and Fe2O3 at Different Temperatures
Authors: Koswattage Kaveenga Rasika , Galpaya Chanaka , Induranga Ashan , Vithanage Vimukthi , Mantilaka M. M. M. G. P. G.
Published: October 2023

The efficiency, durability, and overall performance of a car engine are influenced by several critical factors. The quality and properties of engine oil play a crucial role, and oil is used in internal combustion engines for lubrication and cooling purposes. This research study aimed to compare the impact of fullerene-C60 (99.5%), Fe2O3, and TiO2 nanoparticles on the thermal properties of C.A.L.T.E.X. red engine oil with grades 10W30, 20W40, and 20W50. This study focused on the effect of a nanoparticle concentration of 0.01 wt.% in different engine oil grades at various temperature values of 30-120 ℃. The Nanofluids were prepared using the two-step direct mixing method, employing a magnetic stirrer and an ultrasonicator, ensuring uniform distribution of nanoparticles in the base fluids. The thermal conductivity, thermal diffusivity, and volumetric heat capacity of the base fluids and nanofluids were measured using the FLUCON LAMBDA thermal conductivity meter. Additionally, flash points were measured using the flash point tester. It was concluded that the thermal properties of TiO2 and Fe2O3 showed considerable enhancement; in contrast, Fullerene only showed the 212 ℃ flash point.
VEGFR2 Expression Correlates with Postnatal Development of Brain Arteriovenous Malformations in a Mouse Model of Type I Hereditary Hemorrhagic Telangiectasia
Authors: Han Chul , Nguyen Candice L. , Scherschinski Lea , Schriber Tyler D , Arthur Helen M , Lawton Michael T , Oh S. Paul
Published: October 2023

Brain arteriovenous malformations (BAVMs) are a critical concern in hereditary hemorrhagic telangiectasia (HHT) patients, carrying the risk of life-threatening intracranial hemorrhage. While traditionally seen as congenital, the debate continues due to documented de novo cases. Our primary goal was to identify the precise postnatal window in which deletion of the HHT gene Endoglin (Eng) triggers BAVM development. We employed SclCreER(+);Eng2f/2f mice, enabling timed Eng gene deletion in endothelial cells via tamoxifen. Tamoxifen was given at four postnatal periods: P1-3, P8-10, P15-17, and P22-24. BAVM development was assessed at 2-3 months using latex dye perfusion. We examined angiogenic activity by assessing vascular endothelial growth factor receptor 2 (VEGFR2) expression via Western blotting and Flk1-LacZ reporter mice. Longitudinal magnetic resonance angiography (MRA) was conducted up to 9 months. BAVMs emerged in 88% (P1-3), 86% (P8-10), and 55% (P15-17) of cases, with varying localization. Notably, the P22-24 group did not develop BAVMs but exhibited skin AVMs. VEGFR2 expression peaked in the initial 2 postnatal weeks, coinciding with BAVM onset. These findings support the “second hit” theory, highlighting the role of early postnatal angiogenesis, in initiating BAVM development in HHT type I mice.
Using Ziziphora serpyllacea Leaf Extract to Detoxify Aflatoxin B1 from Various Nuts
Authors: Auteleyeva Laura , Maikanov Balgabay , Sharipbaeva Aigul , Smagulova Ayana
Published: October 2023

The class I carcinogen aflatoxin B1 (AFB1) poses a significant risk to human health. The contamination of food sources contributes to the spread of AFB1, mainly through grains and nuts, from Aspergillus flavus. The high percentage of aflatoxin contamination in various imported nuts in the Republic of Kazakhstan has encouraged researchers to develop a local method of AFB1 detoxification. This research was focused on studying the ability of Ziziphora serpyllace leaf extract growing in the Akmola region of the Republic of Kazakhstan to inactivate aflatoxin B1 in various nuts. For the first time, an extract of Ziziphora serpyllace leaves growing in the territory of the Republic of Kazakhstan was used to detoxify AFB1 in nuts, and this demonstrated low cytotoxic activity, high antimicrobial and high antifungal activity, while preserving the qualitative characteristics of the nuts.
Effect of Exercise Programs on Physical Performance in Community-dwelling Older Adults With and Without Frailty. Systematic review and meta-analysis
Authors: Flores-Bello Cristina , Correa-Muñoz Elsa , Sánchez-Rodríguez Martha A. , Mendoza-Núñez Víctor Manuel
Published: October 2023

Background. The measurement of physical performance constitutes an indicator of physical functional capacity and allows the design of physical exercise programs adapted to the individual abilities and needs of older adults with and without frailty. Aim. To present a synthesis of knowledge on the effect of exercise programs on physical performance in older adults with and without frailty in the community. Method. A systematic review was carried out in accordance with the PRISMA-2020 criteria. The search for articles was made until May 4, 2023 in PubMed, Scopus, Web of Science, Cochrane Library, SciELO and LILACS. The outcome variable was physical performance, measured through the SPPB (Short Physical Performance Battery). The mean difference (MD) was estimated to evaluate the effect. Results. We found 2,483 studies, of which 12 met the eligibility criteria for the systematic review and 9 for the meta-analysis. The effect of exercise on SPPB score was significantly higher in the exercise group compared to control in non-frail older adults with MD=0.51 [95% CI, 0.05 to 0.96, p<0.05]. Likewise, in older adults with frailty, the effect of exercise on the global SPPB score was significantly higher in the exercise group compared to the control with an MD=0.66 [95% CI, 0.09 to 1.24, p<0.05 ]. Conclusion. Our findings suggest that exercise programs are effective in increasing and/or maintaining physical performance in older adults with and without frailty, whose effect is more evident in older adults with frailty, probably due to the greater margin of recovery of intrinsic capacity.
Image Inpainting Forgery Detection: A Review
Authors: Barglazan Adrian-Alin , Brad Remus , Constantinescu Constantin
Published: October 2023

In recent years, significant advancements in the field of machine learning have influenced the domain of image restoration. While these technological advancements present prospects for improving the quality of images, they also present difficulties, particularly the proliferation of manipulated or counterfeit multimedia information on the internet. The objective of this paper is to provide a comprehensive review of existing inpainting algorithms and forgery detections, with a specific emphasis on techniques that are designed for the purpose of removing objects from digital images. In this study, we will examine various techniques encompassing conventional texture synthesis methods, as well as those based on neural networks. Furthermore, we will explore the artifacts associated with the identification of modified photos and present the artifacts frequently introduced by the inpainting procedure and assess the state-of-the-art technology for detecting such modifications. Lastly, we shall look at the available datasets and how the methods compare with each other. Having covered all of the above, the final outcome of this study is to provide a comprehensive perspective on the abilities and constraints to detect images for which an inpainting object removal method was applied.
Next-Gen Manufacturing: Machine Learning for Surface Roughness Prediction in Ti-6Al-4V Biocompatible Alloy Machining
Authors: Kosarac Aleksandar , Tabakovic Slobodan , Mladjenovic Cvijetin , Zeljkovic Milan , Orasanin Goran
Published: October 2023

Mechanical engineering plays an important role in the design and manufacture of medical devices, implants, prostheses, and other medical equipment, where the machining of bio-compatible materials have a special place. There are a lot of different conventional and non-conventional types of machining of biocompatible materials. One of the most frequently used methods is milling. The first part of this paper considers the optimization of machining parameters for minimizing surface roughness in milling biocompatible alloy Ti-6Al-4V. With four factors (cutting speed, feed rate, depth of cut, and cooling/lubricating method), each having three levels, the full factorial design implies 81 experiments have to be carried out. Using the Taguchi method, the experiment number was reduced from 81 to 27 runs through an orthogonal design. According to the analysis of variance (ANOVA), the most significant parameter for surface roughness is feed rate. In the second part possibilities of different ML techniques to create a predictive model for average surface roughness using previously created small dataset are explored. Several ML technologies and techniques that can deal successfully with small dataset were explored. The best results show commonly used machine learning algorithm Random Forest that is widely used in regression problems.
Cold Atmospheric Plasma Jet Treatment Decreases the Survival and the Expression of Oncogenic miRNAs of Oral Carcinoma Cell
Authors: Cheng Yun-Chien , Chang Kuo-Wei , Pan Jian-Hua , Chen Chao-Yu , Chou Chung-Hsien , Tu Hsi-Feng , Li Wan-Chun , Lin Shu-Chun
Published: October 2023

Despite recent advancements, therapies remain ineffective against advanced oral squamous cell carcinoma (OSCC), resulting in unsatisfactory therapeutic outcomes. Cold atmospheric plasma (CAP) offers a promising approach in the treatment of malignant neoplasms. Yet, the exact mechanisms driving CAP-induced cancer cell death are not fully understood. This study revealed a significant reduction in the viability of OSCC cell lines, inactivation of AKT and ERK, and the downregulation of the miR-21, miR-31, miR-134, miR-146a and miR-211 expression followed the CAP treatment. Pretreatment with ZVAD, 3-MA, and Fer-1 synergistically reduced CAP-induced cell death, indicating a combined induction of variable death pathways by CAP. Activation of AKT and ERK, alongside combined treatments using death inhibitors and miRNA mimics, counteracted the cell mortality associated with CAP. CAP-induced downregulation of miR-21, miR-31, miR-187 and miR-211 expression was rescued by AKT and ERK activation. Additionally, CAP treatments notably inhibited the growth of SAS cell xenografts on nude mice. The reduced expression of oncogenic miRNAs in vivo aligned with in vitro findings. In conclusion, our study indicates that CAP jet treatment diminishes OSCC cell viability by abrogating survival signals and oncogenic miRNA expression.
On A Solution of “P vs Np” Millenium Prize Problem Based on the Subset Sum Problem
Authors: Sinchev Bakhtgerey , Sinchev Askar , Mukhanova Aksulu
Published: October 2023

Given a set of distinct non-negative integers X^n and a target certificate S in parametrized form: ∃X^k⊆X^n,∑_(x_i∈X^k)▒x_i =S (k=|X^k |,n=|X^n |). We present a polynomial solution of the subset sum problem with time complexity T≤O(kn)≤O(n^2) and space complexity S≤O(((n-1)n)/2)≤O(n^2 ), so that P = NP.
Postural Orthostatic Tachycardia Syndrome Following SARS-CoV-2 Infection and COVID-19 Vaccination: A Comparative Review
Authors: Mohseni Afshar Zeinab , Mazaherinia Homa , Nazari rostami Hosein , Babazadeh Arefeh , Barary Mohammad , Hashemi Erfan , Ebrahimpour Soheil
Published: October 2023

Postural orthostatic tachycardia syndrome (POTS) and its related symptoms have been identified as a possible complication of COVID-19 infection and vaccination and have recently gained attention. The diagnosis and management of POTS require great care and attention, even under normal circumstances, due to its complex nature. However, the COVID-19 pandemic and its complications have further complicated the diagnosis and management of this syndrome in COVID-19-related settings. The objective of this study is to enhance our comprehension of POTS and POTS-like symptoms in the context of COVID-19. To achieve this, we provide a concise overview of the POTS concept, its potential underlying mechanisms, available clinical reports of POTS following COVID-19 infection and vaccination, as well as the clinical manifestations of this syndrome in COVID-19-related scenarios with a brief overview of its management.
Oxidized Alginate and Nano-Hydroxyapatite as Biodegradable Tanning Agent and Non-Toxic Flame Retardant for cleaner leather tanning and post-tanning processes
Authors: Quaratesi Ilaria , Micu Maria Cristina , Rebba Erica , Carsote Cristina , Proietti Noemi , Di Tullio Valeria , Porcaro Rita , Badea Elena
Published: October 2023

In this study, sodium alginate (SA) was oxidized with potassium periodate to produce an alginate-based tanning agent. Using OSA as a biodegradable tanning agent and a nano-hydroxyapatite (nano-HAp) low concentration suspension to give flame retardancy to leather, eco-design concepts were applied to establish a chrome-, aldehyde-, and phenol-free tanning process. Micro-DSC, 1H NMR, attenuated total reflection mode Fourier transform infrared spectroscopy (FTIR-ATR), and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) were used to investigate the complex matrix collagen-OSA-nano-HAp. Micro-differential scanning calorimetry (micro-DSC) was used to assess OSA's ability to interact with collagen and stabilize the collagen-OSA matrix, while 1H unilateral nuclear magnetic resonance (NMR) was used to investigate the aqueous environment and limitations around collagen molecules caused by their association with OSA and nano-HAp. Industrial standard tests were used to assess mechanical properties and fire resistance of the new leather prototype. The findings reported here indicate that both OSA and nano-HAp are suitable alternatives for cleaner tanning technologies and more sustainable leather.
Mechanical Properties of α-Chitin and Chitosan Biocomposite: A Molecular Dynamic Study
Authors: Salavati Mohammad
Published: October 2023

The mechanical properties of α-chitin and chitosan biocomposite are investigated due to their broad range of potential applications in bioengineering, materials science, and environmental technology. Employing molecular dynamics (MD), and stress-strain analyses, this study comprehensively investigates biopolymers mechanical response and anisotropic mechanical behavior under uniaxial tensile loading conditions in an aqueous environment. Our computational models were validated against existing experimental data, showing high degrees of correspondence. Uniaxial tensile tests revealed that α-chitin exhibits a remarkable ultimate tensile strength (UTS) of 10.07 GPa in the crystalline chain direction (y-axis) at a high strain rate of 0.636, compared to a significantly lower UTS of 2.78 GPa in the perpendicular direction (x-axis) at a lower strain rate of 0.066. The biocomposite nanostructure, encompassing randomly distributed chitosan, reduced stiffness, maintaining remarkable flexibility as α-chitin, with a UTS of 5.03 GPa in the y-axis and 2.34 GPa in the x-axis. Further, the directional elastic modules for α-chitin were calculated as 51.76 GPa and 39.76 GPa in the x and y directions, respectively. In contrast, these values for the α-chitin-chitosan biocomposite were estimated as 31.66 GPa and 26.00 GPa, respectively. The findings provide valuable insights into the distinct mechanical properties of α-chitin and chitosan biocomposite, making a substantial contribution to optimizing these materials for specialized applications.
Electrical Properties of Ferrite Absorber in High-Band 5G System Determined by Open Coaxial Probe and Free Space Methods
Authors: Przesmycki Rafał , Bugaj Marek
Published: October 2023

This article presents the possibilities of using ferrite absorption material for shielding rooms with medical devices in order to additionally protect them against the limits of the electric component of the E field, which are up to 61 V/m. These values may appear in connection with the currently launched 5G system operating in the high-band frequency range, i.e. 28 GHz and 38 GHz, and may cause negative effects on the operation of medical devices. The possibilities of using ferrite absorption material for shielding rooms with medical devices were determined based on the results of measurements of the electrical properties of the ferrite material performed using two methods: the reflection method and the free space method. In the article, the complex electrical permittivity and complex magnetic permeability were determined for a ferrite plate based on measurements of the reflection coefficient and the transmission (attenuation) coefficient. The presented calculation and measurement results were used to show the properties of the ferrite material in the frequency range from 15 GHz to 45 GHz and to show the possibility of using it for shielding rooms as a material absorbing electromagnetic waves in this frequency range.
First Simulations for the EuAPS Betatron Radiation Source
Authors: Frazzitta Andrea , Rossi Andrea Renato , Cianchi Alessandro , Ferrario Massimo , Serafini Luca , Bacci Alberto , Carbone Arianna , Curcio Alessandro , Drebot Illya , Petrillo Vittoria , Conti Marcello Rossetti , Samsam Sanae
Published: October 2023

X-rays production through betatron radiation emission from electron bunches is a valuable resource for several research fields. The EuAPS (EuPRAXIA Advanced Photon Sources) project, within the framework of the EuPRAXIA project, aims to provide 1-10 keV photons (soft X-rays) developing a compact plasma-based system designed to exploit self-injection processes that occur in highly nonlinear laser-plasma interaction (LWFA) to drive electron betatron oscillations. Since the emitted radiation spectrum, intensity, angular divergence, and possible coherence strongly depend on the properties of the self-injected beam, accurate preliminary simulations of the process are necessary to evaluate the optimal diagnostic device specifications. Dedicated tools for these tasks are under development: electron trajectories from particle-in-cell (PIC) simulations are currently undergoing numerical analysis through the calculation of retarded fields and spectra for various plasma and laser parameter combinations. At the same time, an analytical approach is being examined to obtain an expression for the emitted spectrum, assuming linear or quadratic electron energy variation. Code structure and some trajectories analysis results are presented.
A Review of Residential Electricity Load Shifting at the Appliance Level
Authors: Manembu Pinrolinvic , Kewo Angreine , Bramstoft Rasmus , Nielsen Per Sieverts
Published: October 2023

Load shifting is one of the demand side management (DSM) strategies to support the efficiency in the electricity grid during the peak hours demand. Load shifting at the appliance level is interesting to review since the appliance usage is one of the main inputs in the load profile analysis. More review studies in load shifting at the appliance level are required as it is a specific issue of load profile research body, and still limited studies are available at this moment. It is also essential to focus on the appliance usage patterns to better understand the impacts and characteristics of the individual appliance. The existing studies in load shifting have applied common structured literature reviews, and our study addresses the transparency of each stage and sub-stage of the selection of the final list studies. The finding shows that efficiency has been achieved in the installed capacity reduction, cost including emission reductions, and peak consumption reduction. The most applied method in the load shifting at the appliance level is by developing the load shifting optimisation algorithms. This work contributes to provide a transparent process of applying a systematicity literature review, where it becomes a source of knowledge and grounded theory. It contributes to a limited and specific research of load shifting at the appliance level by highlighting and discussing the key findings for the readers. In specific, it contributes to improve energy efficiency by presenting the load shifting methods at the appliance level and identifying the controllable and uncontrollable appliances. This detail review study at the appliance level can make valuable contributions to support decision and policy-making by illuminating new dynamic system in load shifting area in specific, and demand side management in general for energy efficiency.
Synthesis of Water Hyacinth/Cassava Starch Composite as An Environmentally Friendly Plastic Solution
Authors: Syamsuri M. Mahfudz Fauzi , Marzuki Hasan , Setiawan Dedi Wahyu Ari , Rusmaniar Rusmaniar , Astika Tri
Published: October 2023

Abstract. Conventional plastics made from petroleum polymers were the largest contributor to solid waste on earth. Environmentally friendly bioplastic fabricated by compositing starch and natural fibers were proposed to be a solution to this problem. The purpose of this research was to synthesize bioplastic from water hyacinth fiber composite with cassava starch and test its mechanical properties. Bioplastic fabrication was using melt intercalation method using water hyacinth fibers (WHF) with and without alkali treatment mixed with cassava starch (CS) and glycerol as plasticizer. The resulting bioplastic were characterized with FT-IR and tested for mechanical properties. The mechanical test results showed that water hyacinth fiber alkaline treated/cassava starch (WHF-AT/CS) bioplastic has tensile strength, % elongation, and water absorption values of 1.226 MPa, 3.33%, and 10.26%, respectively. While the bioplastic water hyacinth fiber untreated/cassava starch (WHF-UT/CS) has a tensile strength test value, % elongation, and water absorption of 0.306 MPa, 1.67%, and 11.39, respectively.  Therefore it can be said that WHF-AT/CS bioplastic has better mechanical properties when compared to WHF-UT/CS bioplastic.

Keywords:

Biocomposite, Bioplastic, Cassava Starch, Water Hyacinth Fiber
Paradigm shift on the role of mineralocorticoid receptor antagonists in hypertension therapy
Authors: Gilyarevsky S. R. , Ladygina D. O.
Published: October 2023

The literature review is devoted to modern ideas about the role of hyperaldosteronism as one of the important pathophysiological links in hypertension (HTN) development. Data are presented on aldosterone synthesis mechanisms both in healthy and sick people, in particular in primary aldosteronism (PA), as well as in some cases of secondary aldosteronism. The results of modern studies are discussed, which established autonomous formation of aldosterone in elderly and senile people even without formal criteria for PA. The most important stages of studying and solving the hyperaldosteronism problem using surgical or conservative methods areconsidered. Data are presented on target organ damage caused by an increased blood concentration of aldosterone. The influence of the interaction between increased dietary sodium intake and the severity of cardiovascular damage is discussed. Separately, the role of subclinical hyperaldosteronism in the development of hypertension is considered, as well as the possibility of target organ damage in such cases, despite the normal blood pressure level. Modern data on the role of mineralocorticoid receptor antagonists (MRAs), in particular spironolactone, in the treatment of hyperaldosteronism and resistant hypertension are presented. The limitations of MRA use, which are mainly due to reduced kidney function, are considered. In particular, the results of the most important clinical studies are discussed, which became the basis for higher prescription rate of MRAs in the treatment of hypertensive patients.
Prognostic significance of NT-proBNP and sST2 in patients with heart failure with preserved and mildly reduced ejection fraction
Authors: Podzolkov V. I. , Dragomiretskaya N. A. , Tolmacheva A. V. , Shvedov I. I. , Ivannikov A. A. , Akyol I. V.
Published: October 2023

Aim. To study the prognostic significance of cardiobiomarkers - NT-proBNP and soluble suppression of tumorigenecity (sST2) in patients with CHF with preserved (CHFpEF) and mildly reduced EF (CHFmrEF).

Material and methods. Along with a clinical examination, 207 patients (111 men and 96 women), mean age - 72.6 ± 11.4 years, underwent tests for the level of NT-proBNP and sST2 in serum. All patients were divided into 3 groups: 1 - CHFpEF (n=85), 2 - CHFmrEF (n=50); 3 (comparison group)- CHFrEF (n=72). All patients signed informed consent to participate in the study. The primary endpoint was all-cause death in 12 months. Statistical processing of the results was carried out using the Statistica 12.0 and Medcalc programs.

Results. The initial values ​of NT-proBNP in patients with CHFmrEF were 691.9 [248; 1915.5] pg/ml and were significantly higher than those of CHFpEF - 445.8 [214.6; 945.7] pg/ml, but significantly lower than in CHFrEF - 1131.4 [411.5;3039.5] pg/ml, p<0.05. sST2 values ​​in group 1 (23.21 [12.17;48.7] ng/ml and group 2 (27.11 [16.98;53.76] ng/ml) did not differ, but were significantly lower than in patients with CHFrEF (44.6 [21.1; 93.5] ng/ml). After a median of 12 months 51 patients reached the primary endpoint.  All-causes mortality in patients with HFpEF was 11.8%, HFmrEF - 31.9% (p <0.05), and HFrEF – 36%. A retrospective analysis of the data showed that in patients independent of their initial ejection fraction, who survived for 12 months, the levels of NT-proBNP and sST2 were significantly lower than those of the deceased.  In survivors and deceased patients with CHFpEF the values ​​of NT-proBNP and sST2 were 443 [154;862,8] vs 1143,2 [223,9;2021,9] pg/ml (p=0.009) and 22,8 [12,3;33,8]  vs 26,8 [9,6;74,8] ng/mL (p<0.05). In survivors and deceased patients with CHFmrEF the values ​​of NT-proBNP and sST2 were 397.4 [128.9;1088.5] vs 1939.7 [441.9;2536] pg/ml (p=0.009) and 18.6 [14.9;30.27.1] vs 59.9 [53.76;84.4] ng/mL (p=0.002). There were no significant differences in NT-proBNP and sST2 values ​​in patients with cardiac and non-cardiac causes of death. sST2 parameters in deceased patients with CHFpEF (26.8 [9.6;74.8] ng/mL) and CHFmrEF (59.9 [53.76;84.4] ng/mL) also had no significant differences (p >0.05). At ROC analysis to one-year adverse events, both NT-proBNP and sST2 showed a significant predictive value in patients with EF >40% with an optimal cut-off value of 746 pg/ml (AUC 0.709; p = 0.005, sensitivity 62%, specificity 69%) and 27.1 ng/ml (AUC 0.742; p = 0.03, sensitivity 80%, specificity 75.8%) respectively.

Conclusion: NT-proBNP levels >746 pg/ml and sST2 >27.1 ng/ml should be considered as predictors of poor prognosis in CHF patients with LVEF >40%.
Effect of long-term nicorandil therapy on myocardial perfusion parameters according to triphosadenine stress-volume computed tomography in a patient with non-obstructive coronary artery disease: a care report
Authors: Egorkina O. F. , Soboleva G. N. , Gaman S. A. , Karpov Y. A. , Ternovoy S. K.
Published: October 2023

A case of a patient with myocardial perfusion improvement according to volume computed tomography (VCT) of the heart with triphosadenine infusion against the background of optimal therapy, including nicorandil for 3,5 years, is presented. In a patient with an established diagnosis of non-obstructive coronary artery disease (CAD) in 2019, stress-induced myocardial ischemia of left ventricular (LV) septal and lateral area was detected. Repeated investigation 3,5 years later against the background of optimal therapy showed an ischemia decrease in the form of the disappearance of previously detected defects in the basal segments of the anteriorlateral and inferior-lateral walls and the middle segments of the anterior-septal and inferior-lateral walls of the LV.
Modeling of transitional processes in the power transmission of the transmission of a military tracked vehicle
Authors: Chernyshov Volodymyr , Kalinin Pavel , Sergienko Nikolay , Sergienko Anton , Medvediev Nikolay , Khaustov Dmytro
Published: October 2023

The issue of improving the numerical-analytical method of modeling transient processes in the power transmission of a militarytracked vehicle MTV is under consideration. The results of the numerical modeling of dynamic processes in the MTV power transmission using the example of the T-64B in its acceleration mode on a flat concrete track show the significant mutual influence of the power transmission elements and the need to consider the specified processes in the closed system "environment-machine-driver". The proposed method of analytical modeling of the operation of the MTV power transmission allows you to take into account the features of the driver's control of the machine's movement, investigate the operation of the engine control system, analyze the operation of the friction devices of on-board gearboxes, evaluate the performance of the machine's components and transmission units. Ways of improving the methodology of researching transient processes in the power transmission of MTV are given. Based on the research results, the effectiveness of the proposed dynamic research methodology and its extension to other similar research objects have been established.
Newspapers Published by the Employees Against Their Employers in Turkey: Haber and Basin
Authors: GAZEL Ahmet Ali
Published: October 2023

Takvim-i Vekayi started to be published in 1831 and was the first Turkish newspaper published in the Ottoman Empire period. The number of newspapers published in the Ottoman Empire started to increase after 1860. As a result of the increase in the number of newspapers, conflicts between newspaper owners and employees increased. In such cases, newspaper employees often went on strike to protect their interests and ensure that their demands were accepted. However, due to the lack of legal regulations to protect their rights, newspaper employees sometimes adopted different methods of struggle. One of these methods was to publish newspapers against newspaper owners in order to fight against them with the same medium. In the history of the Turkish press, newspaper workers were able to publish their newspapers against their newspaper owners twice, in 1923 and 1961. In 1923, the typesetters published a newspaper named Haber (News). In 1961, the journalists published a newspaper called Basın. As journalists gained relative legal security in 1961, they did not take such an action again in Turkey.
Wellbore Surface Conditioning for Inhibition of Asphaltene Adsorption
Authors: Mohammed Isah , Al Shehri Dhafer , Mahmoud Mohamed , Sultan Abdullah , Kamal Muhammad Shahzad , Alade Olalekan Saheed , Babu Rahul Salin , Patil Shirish
Published: October 2023

Asphaltene adsorption on reservoir rocks, particularly those near the wellbore, has been debated for decades, but a long-term solution is still difficult. This is partially because research into the chemistry of asphaltene is still ongoing, as is the creation of solutions that depend on the structural makeup of asphaltene. Moreover, several interrelated elements have an impact on asphaltene behavior, making it challenging to design a long-lasting solution. This study makes an effort to reduce asphaltene adsorption on carbonate rock samples by applying chelating agents to the surface. To assess the viability of the suggested remedy, adsorption studies, surface energy, and density functional theory calculations were performed.

Results show that asphaltene adsorption on chelating agent-treated carbonate surfaces can be prevented or reduced. The best chelating agent concentration must be established, though. Findings also indicated that the effectiveness of the chelating agent in preventing asphaltene adsorption increased with the number of carboxylic acid groups present in its structure. Furthermore, van der Waals interactions and hydrogen bond formation govern the chelation of Ca2+ from the carbonate surface. This offers information that is only now being reported here. Further findings confirmed the viability of asphaltene adsorption mitigation using fluids containing carboxylic acids. Also, it is necessary to investigate additional fluids that have the potential to coat the surface.
Analysis of research publications of Government and Private University in Karnataka, India: A Scientometric study
Authors: Bandi Ishappa , Laxmeshwar Sameer S , T Harish H
Published: October 2023

This research was done to better understand the two renowned Universities in the state of Karnataka, MAHE in Manipal and VTU in Belagavi. Their research outputs for the last five years are analyzed using the Scopus bibliographical tool. The goal of this study was to determine how the COVID-19 pandemic affected research productivity. Surprisingly, the MAHE (2351) research community published more than three times as many papers as the VTU (744) research community during the pandemic period (2020–21). The MAHE research community prefers to publish in journals > 90%, however just 61% of VTU researchers do the same. This is another significant conclusion from the study. Importantly, just 5% of researchers at MAHE publish in conferences compared to around 19% of researchers at VTU. This demonstrates that MAHE gives journal publication a greater preference; as a result, the impact of this policy is evident in the data analysis.
Structural characteristics of Niaouli forests, biodiversity, and ethnobotanical importance of the valuable species
Authors: GANGLO Isis Togbédji , KOURA Kourouma , KIKI Edmond , HOUNSA Michael , KINGBO Armand , BELLO Saliou , AOUDJI Augustin K. N. , GANGLO Jean Cossi
Published: October 2023

In Benin, forest resources are limited and are in the grip of alarming degradation. In southern Benin, the Niaouli forests (6°40' to 6°45' North Lat. and 2°05' to 2°10' East Long.) require special attention given their state of degradation leading to loss of biodiversity. In order to contribute to the sustainable management of the forests, our investigations focused on the characterization of the structure, floristic diversity, and forms of use of the valuable species. The data was collected by systematic sampling with rectangular meshes of 100 m × 200 m in square plots of one (01) ha each. In total, seven (07) plots were installed for the determination of dendrometric and biodiversity parameters. The regeneration of the species was counted in quadrats of 100 m² installed on a diagonal of each plot. Ethnobotanical surveys were carried out within local populations, on a sample of 188 people made of heads of peasant households or their representatives, carpenters, traditional healers, and loggers in order to identify valuable species and appraise their ethnobotanical importance. Four valuable species were identified. They were Albizia zygia, Antiaris toxicaria, Ceiba pentandra, and Newbouldia laevis. The diversity parameters showed that the forests of Niaouli are characterized by a low floristic diversity in comparison with the forest ecosystems of southern Benin. The main valuable species of the Niaouli forests were experiencing a regeneration problem likely to hinder their sustainability and sustainable use. Albizia zygia, Antiaris toxicaria, and Ceiba pentandra are used more in the form of wood respectively by 85 %, 50 %, and 75 % of respondents. Newbouldia laevis is used more in the form of an infusion by 33 %, fodder by 21 %, and wood by 21 % of respondents. Respondents cited 58 diseases treated with species from the Niaouli forests. Considering the results obtained, regular reforestation and the introduction of new adapted species must be carried out to increase the biodiversity and ecosystem services of the forests.
Ptsd Symptoms Comparison Emdr and Nfb With Ipv Survivors: Ex- Post-facto Study
Authors: Shaikh Huda
Published: October 2023

Given the prevalence of post-traumatic stress disorder symptoms in intimate partner violence survivors, the need for personalized treatment plans for intimate partner violence (IPV) survivor post-traumatic stress disorder (PTSD) care, and no comparison of eye movement desensitization and reprocessing (EMDR) and neurofeedback therapy (NFB) in response to PTSD care, the researcher aimed to fill the gap in research. Using archival data, a comparison between EMDR therapy and NFB therapy in response to IPV survivor PTSD was analyzed. While there exists support for each modality in the existing literature, there does not exist a comparison of the two in response to IPV survivor PTSD symptoms. The theoretical lens utilized for the study were the theory of neuroscience (TN) and humanistic person-centered theory (PCT). The applied research methodology was quantitative, and the research design was ex-post-facto quasi-experimental. Findings did not support a statistically significant difference between the EMDR group and the NFB group in response to pre and post PTSD symptoms thereby failing to reject the null hypothesis for the main research question of the study. Findings pertaining to the sub-questions however noted a statically significant decrease in pre-and post-mean scores within the EMDR group and the NFB group thereby rejecting the null hypotheses for both sub-questions. The study’s findings suggest that NFB carries similar relief of PTSD symptoms as EMDR does. Several limitations pertaining to the study sample’s characteristics, external factors, and the study’s design exist. For example, given the study’s design, a control group was not present. Recommendations for future research include considering the interventions, ENDR and NFB, during the conceptualization and development of theories to test into practice while also testing the efficacy of other alternative therapeutic interventions that serve to be helpful for PTSD care. By doing so, researchers may be able to develop appropriate, effective, and restorative care for IPV survivors suffering from PTSD symptoms along with a wide variety of other mental health concerns.
Study protocol: a core outcome set for perioperative exercise clinical effectiveness trials for lung cancer patients
Authors: Zhou Wanjun , Zhang Yawen , Wang Zhiwei , Zhang Liang , Zhang Xinqiong
Published: October 2023

Background
Outcome assessment in perioperative exercise trials of lung cancer is heterogeneous, often omitting those that are important and patient-relevant. This hinders evidence synthesis. To solve this problem, a core outcome set, an agreed standardized set of outcomes to be measured and reported to reduce heterogeneity among outcome measures, is needed. This study protocol describes the methodology, aiming to develop a core outcome set for perioperative exercise intervention trials for lung cancer in clinical practice.
Methods
The project will follow the standard methodology recommended by the Core Outcome Measures in Effectiveness Trials (COMET) initiative, Which will be divided into four steps. Stage Ⅰ: Conduct a scoping review of outcomes reported in clinical trials and protocols to develop a list of potential outcome domains.. Stage Ⅱ: Conduct semi-structured interviews to obtain important outcomes for patients. Stage Ⅲ: Choose the most important outcomes by conducting two-round Delphi surveys. Stage Ⅳ: Establish consensus in a face-to-face meeting to discuss the final core outcome set.
Discussion
This is the first project identified for the core outcome set of outcomes for perioperative exercise trials for lung cancer, which will improve the quality, comparability, and usability of future trials and positively impact the perioperative exercise and the care of patients with lung cancer.
Trials registration
Core Outcome Measurement in effectiveness Trials (COMET) Initiative database registration:
https://www.comet-initiative.org/Studies/Details/2091
Pre-Job loss Grief Reactions and Work Attachment among Sick-Listed Employees: Introduction of the Imminent Job Loss Scale
Authors: Eersel Janske H. W. , Wickham Miriam I. , Smid Geert E. , Boelen Paul A.
Published: October 2023

Background: With this study, we aimed to explore the emotional experiences of sick-listed employees facing imminent job loss, as this emotional distress may hinder successful job search outcomes. The study had two objectives: (1) to develop and validate the Imminent Job Loss Scale (IJLS) for assessing pre-job loss grief reactions and (2) to examine its relationship to work attachment.
Methods: Development of the 9-item IJLS was carried out using feedback from an expert panel, consisting of five academic experts in grief and labour, five re-integration specialists, and five sick-listed employees facing imminent job loss. The psychometric properties of the IJLS were evaluated, and its association with work attachment was examined using data from 200 sick-listed employees facing imminent job loss.
Results: The IJLS demonstrated strong internal consistency and temporal stability, distinctiveness from depression and anxiety symptoms, and strong convergent validity. Work-centrality and organizational commitment were positively related to pre-job loss grief reactions, while work engagement and calling showed no significant associations.
Conclusion: This study provides valuable insights into pre-job loss grief reactions and shows the potential utility of the IJLS for screening and monitoring purposes. Understanding pre-job loss grief reactions can improve the re-integration and job prospects of sick-listed employees. In future research, explorations of these dynamics should continue to provide better support to sick-listed employees during this challenging period.