bluuebunny/crossref_metadata_2025 huggingface dataset:
An update on the seizures beget seizures theory
Authors: Jiruska Premysl , Freestone Dean , Gnatkovsky Vadym , Wang Yujiang
Published: July 2023

Seizures beget seizures is a longstanding theory that proposed that seizure activity can impact the structural and functional properties of the brain circuits in ways that contribute to epilepsy progression and the future occurrence of seizures. Originally proposed by Gowers, this theory continues to be quoted in the pathophysiology of epilepsy. We critically review the existing data and observations on the consequences of recurrent seizures on brain networks and highlight a range of factors that speak for and against the theory. The existing literature demonstrates clearly that ictal activity, especially if recurrent, induces molecular, structural, and functional changes including cell loss, connectivity reorganization, changes in neuronal behavior, and metabolic alterations. These changes have the potential to modify the seizure threshold, contribute to disease progression, and recruit wider areas of the epileptic network into epileptic activity. Repeated seizure activity may, thus, act as a pathological positive‐feedback mechanism that increases seizure likelihood. On the other hand, the time course of self‐limited epilepsies and the presence of seizure remission in two thirds of epilepsy cases and various chronic epilepsy models oppose the theory. Experimental work showed that seizures could induce neural changes that increase the seizure threshold and decrease the risk of a subsequent seizure. Due to the complex nature of epilepsies, it is wrong to consider only seizures as the key factor responsible for disease progression. Epilepsy worsening can be attributed to the various forms of interictal epileptiform activity or underlying disease mechanisms. Although seizure activity can negatively impact brain structure and function, the “seizures beget seizures” theory should not be used dogmatically but with extreme caution.
Automated measurement of infant and mother Duchenne facial expressions in the Face‐to‐Face/Still‐Face
Authors: Ahn Yeojin Amy , Önal Ertuğrul Itir , Chow Sy‐Miin , Cohn Jeffrey F. , Messinger Daniel S.
Published: July 2023

Although still‐face effects are well‐studied, little is known about the degree to which the Face‐to‐Face/Still‐Face (FFSF) is associated with the production of intense affective displays. Duchenne smiling expresses more intense positive affect than non‐Duchenne smiling, while Duchenne cry‐faces express more intense negative affect than non‐Duchenne cry‐faces. Forty 4‐month‐old infants and their mothers completed the FFSF, and key affect‐indexing facial Action Units (AUs) were coded by expert Facial Action Coding System coders for the first 30 s of each FFSF episode. Computer vision software, automated facial affect recognition (AFAR), identified AUs for the entire 2‐min episodes. Expert coding and AFAR produced similar infant and mother Duchenne and non‐Duchenne FFSF effects, highlighting the convergent validity of automated measurement. Substantive AFAR analyses indicated that both infant Duchenne and non‐Duchenne smiling declined from the FF to the SF, but only Duchenne smiling increased from the SF to the RE. In similar fashion, the magnitude of mother Duchenne smiling changes over the FFSF were 2–4 times greater than non‐Duchenne smiling changes. Duchenne expressions appear to be a sensitive index of intense infant and mother affective valence that are accessible to automated measurement and may be a target for future FFSF research.
Greater reliance on glycolysis is associated with lower mitochondrial substrate oxidation and insulin sensitivity in infant myogenic MSCs
Authors: Jevtovic Filip , Zheng Donghai , Lopez Christian A. , Kern Kara , Tanner Charles J. , Jones Terry E. , Pories Walter J. , Dohm G. Lynis , Houmard Joseph A. , May Linda E. , Broskey Nicholas T.
Published: July 2023

In infant myogenically differentiated mesenchymal stem cells, greater production of nonoxidized glycolytic products was directly proportional to lower substrate oxidation and insulin resistance. Glucose oxidation was inversely correlated with infant blood lactate. This suggests that innate differences in infant substrate oxidation exist at birth and could be associated with the development of metabolic disease later in life. Clinical assessment of infant blood lactate could be used as an early indicator of skeletal muscle phenotype.
Altered gut microbiota–host bile acid metabolism in IBS-D patients with liver depression and spleen deficiency pattern
Authors: Du Liqing , Zhang Zhaozhou , Zhai Lixiang , Xu Shujun , Yang Wei , Huang Chunhua , Lin Chengyuan , Zhong Linda L. D. , Bian Zhaoxiang , Zhao Ling
Published: July 2023

Background

Dysregulation of gut microbiota–host bile acid (BA) co-metabolism is a critical pathogenic factor of diarrhea-predominant irritable bowel syndrome (IBS-D). Traditional Chinese Medicine (TCM), instructed by pattern differentiation, is effective in treating IBS-D, in which liver depression and spleen deficiency (LDSD) is the most prevalent pattern. Still, it is unclear the linkage between the LDSD pattern and the BA metabolic phenotype.

Purpose

This study aimed to uncover the biological basis of the LDSD pattern from the BA metabolic perspective.

Methods

Patients with IBS-D completed questionnaires regarding the irritable bowel severity scoring system (IBS-SSS), stool frequency, Stool Bristol scale, and Self-Rating Scales of mental health. Fasting blood and morning feces were collected to analyze the gut metagenome and BA-related indices/metabolites.

Results

IBS-D patients with LDSD had a higher incidence of BA overexcretion (41% vs. 23% non-LDSD) with significant elevations in fecal total BAs and serum BA precursor 7α-hydroxy-4-cholesten-3-one levels. Compared to controls or non-LDSD patients, LDSD patients had a featured fecal BA profile, with higher proportions of deoxycholic acid (DCA), 7-ketodeoxycholic acid, and lithocholic acid. It is consistent with the BA-metabolizing genomic changes in the LDSD gut microbiota characterized by overabundances of 7-dehydroxylating bacteria and BA-inducible genes (baiCD/E/H). The score of bowel symptoms (stool frequency and abdominal pain) showing greater severity in the LDSD pattern were positively correlated with bai-expressing bacterial abundances and fecal DCA levels separately.

Conclusion

We clarified a differed BA metabolic phenotype in IBS patients with LDSD, which closely correlates with the severity of bowel symptoms. It demonstrates that gut microbiota and host co-metabolism of BAs would provide crucial insight into the biology of the LDSD pattern and its internal relationship with IBS progression.
Financialization Hypothesis: A Theoretical and Empirical Critique
Authors: Subasat Turan , Mavroudeas Stavros
Published: July 2023

The financialization hypothesis (FH) is a popular leitmotiv which argues that the financial system conquers the commanding heights of the capitalist economy. It maintains that finance gained independence from productive-capital and began to dominate it. The FH bases this argument on several empirical claims concerning the size and the strategic role of financial entities. This article offers a critique of crucial analytical and empirical claims of the FH. It argues that the FH overrates the importance of novel financial instruments, misunderstands their function and, thus, fails to situate the role of finance in the capitalist system. Especially, it erroneously divorces finance from and superimposes it on productive-capital. Moreover, this article argues that crucial empirical claims of the FH do not stand up to scrutiny.
High-performance towing cable hydrophone array with an improved ultra-sensitive fiber-optic distributed acoustic sensing system
Authors: Yan Guofeng , Wang Delin , Long JUNqiu , Jiang Lang , Gong Yuan , Ran Zengling , Rao Yunjiang
Published: July 2023

A high-performance towing cable hydrophone array based on an improved ultra-sensitive fiber-optic distributed acoustic sensing system (uDAS) with picostrain sensitivity is demonstrated and tested in sea trial, for the first time. A new composite transducer is designed and optimized to enhance the acoustic pressure sensitivity significantly. A sea trial is carried out to test the performances of such a hydrophone array, including flow noise, underwater acoustic signal capture capacity, beamforming processing and localization of artificial source targets. The array exhibits high sensitivity and low noise floor. An average sensitivity of −129.23 dB re rad/µPa at frequencies from 10 Hz to 1500 Hz has been achieved. The localization at distances of 5 km and 10 km is realized, respectively, validating the excellent remote detection and positioning capability of the hydrophone system. The proposed towing cable system, with high sensitivity, simple structure and remote target localization ability, may pave a way for development of the next generation of high-performance light-weighting hydrophone arrays for towing applications.
Flash-profilometry: fullfield lensless acquisition of spectral holograms for coherence scanning profilometry
Authors: Falldorf Claas , Thiemicke Fabian , Müller André F. , Agour Mostafa , Bergmann Ralf B.
Published: July 2023

Flash-profilometry is a novel measurement approach based on the fullfield lensless acquisition of spectral holograms. It is based on spectral sampling of the mutual coherence function and the subsequent calculation of its propagation along the optical axis several times the depth-of-field. Numerical propagation of the entire coherence function, rather than solely the complex amplitude, allows to digitally reproduce a complete scanning white-light interferometric (WLI) measurement. Hence, the corresponding 3D surface profiling system presented here achieves precision in the low nanometer range along an axial measurement range of several hundred micrometers. Due to the lensless setup, it is compact, immune against dispersion effects and lightweight. Additionally, because of the spectral sampling approach, it is faster than conventional coherence scanning WLI and robust against mechanical distortions, such as vibrations and rigid body movements. Flash-profilometry is therefore suitable for a wide range of applications, such as surface metrology, optical inspection, and material science and appears to be particularly suitable for a direct integration into production environments.
Multi-nodes dissemination of stable radio frequency with 10−17 instability over 2000 km optical fiber
Authors: Gao Hao , Zhao Baodong , Zhao Zhuoze , Cheng Jiahui , Liu Chenxia , Chen Ziyang , Jiang Tianwei , Luo Bin , Yu Song , Guo Hong
Published: July 2023

To meet the demand of flexible access for high-precision synchronization frequency, we demonstrate multi-node stable radio frequency (RF) dissemination over a long-distance optical fiber. Stable radio frequency signals can be extracted at any node along the optical fiber, not just at the endpoint. The differential mixing structure (DMS) is employed to avoid the frequency harmonic leakage and enhance the precision. The phase-locked loop (PLL) provides frequency reference for the DMS while improving the signal to noise ratio (SNR) of dissemination signal. We measure the frequency instability of multi-node stable frequency dissemination system (MFDS) at different locations along the 2,000 km optical fiber. The measured short-term instability with average time of 1 s are 1.90 × 10−14 @ 500 km, 2.81 × 10−14 @ 1,000 km, 3.46 × 10−14 @ 1,500 km, and 3.84 × 10−14 @ 2,000 km respectively. The long-term instability with average time of 10,000 s are basically the same at any position of the optical fiber, which is about (6.24 ± 0.05) × 10−17. The resulting instability is sufficient for the propagation of precision active hydrogen masers.
Linear optical random projections without holography
Authors: Ohana Ruben , Hesslow Daniel , Brunner Daniel , Gigan Sylvain , Müller Kilian
Published: July 2023

We introduce what we believe to be a novel method to perform linear optical random projections without the need for holography. Our method consists of a computationally trivial combination of multiple intensity measurements to mitigate the information loss usually associated with the absolute-square non-linearity imposed by optical intensity measurements. Both experimental and numerical findings demonstrate that the resulting matrix consists of real-valued, independent, and identically distributed (i.i.d.) Gaussian random entries. Our optical setup is simple and robust, as it does not require interference between two beams. We demonstrate the practical applicability of our method by performing dimensionality reduction on high-dimensional data, a common task in randomized numerical linear algebra with relevant applications in machine learning.
Neural network-aided optimisation of a radio-frequency atomic magnetometer
Authors: Yao Han , Maddox Benjamin , Renzoni Ferruccio
Published: July 2023

Efficient unsupervised optimisation of atomic magnetometers is a requirement in many applications, where direct intervention of an operator is not feasible. The efficient extraction of the optimal operating conditions from a small sample of experimental data requires a robust automated regression of the available data. Here we address this issue and propose the use of general regression neural networks as a tool for the optimisation of atomic magnetometers which does not require human supervision and is efficient, as it is ideally suited to operating with a small sample of data as input. As a case study, we specifically demonstrate the optimisation of an unshielded radio-frequency atomic magnetometer by using a general regression neural network which establishes a mapping between three input variables, the cell temperature, the pump beam power and the probe beam power, and one output variable, the AC sensitivity. The optimisation results into an AC sensitivity of 44 fT/Hz at 26 kHz.
Mutual collimation self-calibration for dual-comb ranging-based multilateral coordinate measurement
Authors: Jiang Ruilin , Zhou Siyu , Yang Qingzhao , Wu Guanhao
Published: July 2023

We propose a self-calibration method for multilateration based on dual-comb absolute distance measurement. By performing mutual collimation measurements between multilateral measurement bases, we could measure the system parameters in a multilateration system with high precision and efficiency. We demonstrated a multilateral coordinate measurement system based on the proposed self-calibration method. The system realized rapid coordinate measurement with micron-level precision in both tested directions.
Women drive efforts to highlight concealable stigmatized identities in U.S. academic science and engineering
Authors: Busch Carly A. , Cooper Katelyn M. , Brownell Sara E.
Published: July 2023

Concealable stigmatized identities (CSIs) are hidden identities that carry negative stereotypes and can result in a loss of social status if revealed. Instructors often choose to conceal these CSIs due to anticipated negative student reactions, yet revealing CSIs can have a positive impact on undergraduates. Women are generally more likely to reveal personal aspects about themselves in social situations, but may face greater consequences for revealing a stigmatized identity to students given their already marginalized position in academic science and engineering. Therefore, in this study, we were interested in understanding to what extent there are differences between men and women science and engineering instructors in (i) the representation of CSIs, (ii) their decisions to reveal CSIs to undergraduates in their classes, and (iii) their perceived stigma of CSIs. Based on a national survey of over 2,000 instructors in science and engineering from very high research activity doctoral institutions, we found that women were more likely than men to report having depression, anxiety, or a disability. Of instructors who held CSIs, women had 1.5x higher odds than men of revealing their CSIs to some undergraduates compared to no undergraduates and perceived greater stigma associated with all CSIs. Despite perceiving greater stigma associated with concealable stigmatized identities, women are more likely to reveal their CSIs to college science and engineering students, leading the way to a more diverse and inclusive scientific community by demonstrating themselves as role models for these identities.
Antigen concentration, viral load, and test performance for SARS-CoV-2 in multiple specimen types
Authors: Golden Allison , Oliveira-Silva Michelle , Slater Hannah , Vieira Alexia Martines , Bansil Pooja , Gerth-Guyette Emily , Leader Brandon T. , Zobrist Stephanie , Braga Ferreira Alan Kennedy , Santos de Araujo Erika Crhistina , de Lucena Cruz Catherine Duran , Garbin Eduardo , Bizilj Greg T. , Carlson Sean J. , Sagalovsky Mariana , Pal Sampa , Gupta Vin , Wolansky Leo , Boyle David S. , Vieira Dall’Acqua Deusilene Souza , Naveca Felipe Gomes , do Nascimento Valdinete Alves , Villalobos Salcedo Juan Miguel , Drain Paul K. , Costa Alexandre Dias Tavares , Pereira Dhélio , Domingo Gonzalo J.
Published: July 2023

The relationship between N-antigen concentration and viral load within and across different specimens guides the clinical performance of rapid diagnostic tests (RDT) in different uses. A prospective study was conducted in Porto Velho, Brazil, to investigate RDT performance in different specimen types as a function of the correlation between antigen concentration and viral load. The study included 214 close contacts with recent exposures to confirmed cases, aged 12 years and older and with various levels of vaccination. Antigen concentration was measured in nasopharyngeal swab (NPS), anterior nares swab (ANS), and saliva specimens. Reverse transcriptase (RT)–PCR was conducted on the NPS and saliva specimens, and two RDTs were conducted on ANS and one RDT on saliva. Antigen concentration correlated well with viral load when measured in the same specimen type but not across specimen types. Antigen levels were higher in symptomatic cases compared to asymptomatic/oligosymptomatic cases and lower in saliva compared to NPS and ANS samples. Discordant results between the RDTs conducted on ANS and the RT-PCR on NPS were resolved by antigen concentration values. The analytical limit-of-detection of RDTs can be used to predict the performance of the tests in populations for which the antigen concentration is known. The antigen dynamics across different sample types observed in SARS-CoV-2 disease progression support use of RDTs with nasal samples. Given lower antigen concentrations in saliva, rapid testing using saliva is expected to require improved RDT analytical sensitivity to achieve clinical sensitivity similar to rapid testing of nasal samples.
Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results
Authors: Oey Abbie , McClure Matthew , Symons Julian A. , Chanda Sushmita , Fry John , Smith Patrick F. , Luciani Kathia , Fayon Michael , Chokephaibulkit Kulkanya , Uppala Rattapon , Bernatoniene Jolanta , Furuno Kenji , Stanley Thorsten , Huntjens Dymphy , Witek James ,   on behalf of the 503 and RSV2004 Study Groups
Published: July 2023

Respiratory syncytial virus (RSV) infection is the leading cause of infant hospitalizations and mortality. Lumicitabine, an oral nucleoside analog was studied for the treatment of RSV. The phase 1b and phase 2b studies reported here assessed the safety, pharmacokinetics, and pharmacodynamics of lumicitabine in infants/neonates hospitalized with RSV. In the phase 1b study, infants (≥1 to ≤12 months) and neonates (<28 days) received a single-ascending or multiple-ascending doses (single loading dose [LD] then 9 maintenance doses [MD] of lumicitabine, or placebo [3:1]). In the phase 2b study, infants/children (28 days to ≤36 months old) received lumicitabine 40/20 mg/kg, 60/40 mg/kg LD/MD twice-daily or placebo (1:1:1) for 5 days. Safety, pharmacokinetics, and efficacy parameters were assessed over 28 days. Lumicitabine was associated with a dose-related increase in the incidence and severity of reversible neutropenia. Plasma levels of ALS-008112, the active nucleoside analog, were dose-proportional with comparable mean exposure levels at the highest doses in both studies. There were no significant differences between the lumicitabine groups and placebo in reducing viral load, time to viral non-detectability, and symptom resolution. No emergent resistance-associated substitutions were observed at the RSV L-gene positions of interest. In summary, lumicitabine was associated with a dose-related increase in the incidence and severity of reversible neutropenia and failed to demonstrate antiviral activity in RSV-infected hospitalized infants. This contrasts with the findings of the previous RSV-A adult challenge study where significant antiviral activity was noted, without incidence of neutropenia.

Trial registration

ClinicalTrials.gov Identifier: NCT02202356 (phase 1b); NCT03333317 (phase 2b).
Patient perspectives on the role of nurses in HIV pre-exposure prophylaxis care (PrEP-RN)
Authors: Orser Lauren , O’Byrne Patrick , Holmes Dave
Published: July 2023

Introduction

In response to ongoing new HIV diagnoses among gay, bisexual, and other men who have sex with men (gbMSM) and limited access points for HIV pre-exposure prophylaxis (PrEP) care, we established Canada’s first nurse-led HIV prevention service in Ottawa, Canada—PrEP-RN. As part of this service, registered nurses became the primary provider in PrEP delivery and monitoring.

Objectives

To (1) gather patients’ sentiments and experiences related to nurse-led PrEP and (2) identify the implications for nurses working in sexual healthcare.

Methodology

Qualitative interviews were conducted with 14 gbMSM participants who had received, or were presently enrolled in, HIV prevention care from nurses in the PrEP-RN clinic. Interview transcripts were reviewed and analyzed using thematic analysis.

Results

Our analysis revealed two major themes of: The Sexual Health Nurse as the Expert and Patients Reliance on Nurses. The first theme discussed patients’ positive attitudes toward nurses, in terms of the knowledge nurses possessed and the kind and efficient services they. The accommodating nature of nurses, however, led patients to become dependent on their care, which was the focus of the second theme. This reliance on nurses created challenges when patients transitioned from PrEP-RN to alternate providers for ongoing care.

Conclusion

These findings were examined to understand the effect of patients’ perceptions of nurses on nursing practice. Despite patients’ confidence in nurses’ ability to provide PrEP care, the expectations they placed onto nurses to address the totality of their needs created competing demands for nurses to be both a leader in HIV prevention care—and fulfill the image of the caring, healthcare ‘hero’, which created feelings of moral distress among nurses. As increasing initiatives focus on task-shifting of healthcare roles to nurses, understanding the patients’ perspective is essential in maintaining effective nurse-patient relationships.
Evaluation of the introduction of a healthy food and drink policy in 13 community recreation centres on the healthiness and nutrient content of customer purchases and business outcomes: An observational study
Authors: Naughton Shaan Stephanie , Romaniuk Helena , Peeters Anna , Chung Alexandra , Jerebine Alethea , Orellana Liliana , Boelsen-Robinson Tara
Published: July 2023

Introduction

This observational study assessed the introduction of a comprehensive healthy food and drink policy across 13 community organisation managed aquatic and recreation centres in Victoria, Australia, and the associated changes on business outcomes, and the healthiness of purchases. The policy, based on state government guidelines, mandated that food and drink availability be based on healthiness classification: ’red’ (limit) <10%, and ‘green’ (best choice) >50%, and the remainder ‘amber’ (choose carefully).

Methods

Six years of monthly sales data were split into three periods, prior to (1/01/2013–31/12/2014), during (1/01/2015–31/12/2016) and post (1/1/2017–31/12/2018), policy implementation. Using point-of-sale data, food and drink nutrient content, and state guidelines, items were classified as ‘red’/‘amber’/‘green’. Linear models with Newey West standard errors were fitted to compare the mean value of outcomes between post- to pre-policy implementation periods, for each outcome and centre; and were pooled using random effect meta-analyses.

Results

Comparing post- to pre-policy implementation periods, total food sales did not change (mean percentage difference: -3.2% (95% confidence interval (CI) -21% to 14%), though total drink sales declined -27% (CI -37% to -17%). The mean percentage of ‘red’ foods sold declined by -15% (CI -22% to -7.7%), ‘amber’ food sales increased 11% (CI 5.5% to 16%). ‘Green’ food sales did not change (3.3%, CI -1.4% to 8.0%). The mean percentage of ‘red’ drinks sold declined -37% (CI -43% to -31%), ‘amber’ and ‘green’ drink sales increased by 8.8% (CI 3.6% to 14%) and 28% (CI 23% to 33%), respectively. The energy density and sugar content (percentage of total weight/volume) of both food and drinks decreased.

Conclusions

This study has shown that the implementation of a policy to improve the health of retail food environments can result in a shift towards healthier purchases. Sales revenue from foods did not decline, though revenue from drinks did, indicating future research needs to explore mitigation of this.
Treatment-induced increase in total body potassium in patients at high risk of ventricular arrhythmias; a randomized POTCAST substudy
Authors: Winsløw Ulrik , Sakthivel Tharsika , Zheng Chaoqun , Bosselmann Helle , Haugan Ketil , Bruun Niels , Larroudé Charlotte , Iversen Kasper , Saffi Hillah , Frandsen Emil , Oturai Peter , Jensen Holger Jan , Vinther Michael , Risum Niels , Bundgaard Henning , Jøns Christian
Published: July 2023

Objective

Hypokalemia is associated with increased risk of arrhythmias and it is recommended to monitor plasma potassium (p-K) regularly in at-risk patients with cardiovascular diseases. It is poorly understood if administration of potassium supplements and mineralocorticoid receptor antagonists (MRA) aimed at increasing p-K also increases intracellular potassium.

Methods

Adults aged≥18 years with an implantable cardioverter defibrillator (ICD) were randomized (1:1) to a control group or to an intervention that included guidance on potassium rich diets, potassium supplements, and MRA to increase p-K to target levels of 4.5–5.0 mmol/l for six months. Total-body-potassium (TBK) was measured by a Whole-Body-Counter along with p-K at baseline, after six weeks, and after six months.

Results

Fourteen patients (mean age: 59 years (standard deviation 14), 79% men) were included. Mean p-K was 3.8 mmol/l (0.2), and mean TBK was 1.50 g/kg (0.20) at baseline. After six-weeks, p-K had increased by 0.47 mmol/l (95%CI:0.14;0.81), p = 0.008 in the intervention group compared to controls, whereas no significant difference was found in TBK (44 mg/kg (-20;108), p = 0.17). After six-months, no significant difference was found in p-K as compared to baseline (0.16 mmol/l (-0.18;0.51), p = 0.36), but a significant increase in TBK of 82 mg/kg (16;148), p = 0.017 was found in the intervention group compared to controls.

Conclusions

Increased potassium intake and MRAs increased TBK gradually and a significant increase was seen after six months. The differentially regulated p-K and TBK challenges current knowledge on potassium homeostasis and the time required before the full potential of p-K increasing treatment can be anticipated.

Trial registration

www.clinicaltrials.gov (NCT03833089).
An analysis of the leverage effect of “Internet +” on the economic spillover of sports industry
Authors: Yi Cuixia , Tao Yang , Bo Fu , Zhipeng Liu , Yu Dong , Lingzhi Liu
Published: July 2023

Given the unprecedented and profound impact on the traditional sports industry and its economic driving force brought by the “Internet +”, the purpose of this study is to explore the driving relationship between the sports industry and local economic development and deconstruct the dynamic regulation mechanism of “Internet +” on the economic spillover of the sports industry. Empirical data collected from China’s 11 inter-provincial panel data from 2015–2019 were analyzed through the fixed-effects and threshold models. The study finds that the economic spillover of the sports industry has significantly promoted regional economic development, and the regulation effect of the Internet has complex non-linear characteristics. Only when Internet development exceeds a specific threshold can it develop a benign complementary mechanism with the sports industry. The impact of “Internet +” on the threshold regulation of the sports industry economic spillover has spatial and temporal differentiation characteristics in the three dimensions of Internet hardware level, Internet penetration rate, and Internet application value. The results of this study extend the current study, indicating that it is a practical choice for local governments to develop the economy through the sports industry. Provinces and cities should enhance the Internet penetration rate, expand Internet business applications, and upgrade Internet development to a specific point to maximize the drive of positive spillover. Regional heterogeneity requires differential regulation strategies and more concentration on the middle and western regions.
Cement bonded composites - A mechanical review
Authors: Frybort Stephan , Mauritz Raimund , Teischinger Alfred , Müller Ulrich
Published: July 2023

Over the last years promising cement bonded wood composites for structural purposes have evolved. Durability, toughness, high dimen-sional stability, resistance against environmental influences such as biodegradation or weathering but also availability of the raw material as well as economic factors are features which can make cement-bonded composites superior to conventionally bonded composites. This paper reviews the relationship of diverse parameters, including density and particle size on mechanical and physical properties of cement bonded composites, based on published sources from the last 60 years. For general and recent information about bonding mechanisms, compatibility and setting problems, determination and improvement of compatibility, the used raw materials as well as accelerators are discussed. The main part deals with failure mechanisms in connection with several production parameters. Furthermore, the influence of particle size and geometry, orientation of the particles, cement-wood ratio and the effect of accelerators and treatment of the particles on modulus of elasticity, modulus of rupture as well as thickness swelling are discussed.
Identidad transoceánica de resistencia en Manuel Zapata Olivella
Authors: Gutiérrez Villegas Juan Armando
Published: July 2023

El ritual y la palabra mítica constituyen la base de la reivindicación social que plantea Zapata Olivella en Changó, el Gran Putas. El texto contiene una revisión sobre la construcción de identidades en el marco de la nación, de sujetos migrantes y desterritorializados, la historia de despojo de los africanos que llegaron a América cargando únicamente con sus memorias. Se plantea que las múltiples expresiones sociopolíticas y culturales de la diáspora africana se constituyen como un proyecto alternativo y constitutivo de la modernidad. La reivindicación de la afrodiáspora, no se enfoca unilateralmente en la idealización de una imagen estática del tiempo pasado, sino que propone el despertar de unas memorias ancestrales como fuente de conocimiento y poder.
La heredera como transgresora de una memoria
Authors: Cabarcas Morales Yoiseth patricia
Published: July 2023

Este artículo es un análisis sobre ¿cómo la herencia de una memoria puede ser transgredida cambiada, interrumpida e intervenida por medio de actos? En dos escenas de las obras Fe en disfraz de Mayra Santos-Febres y Palabra, ojos y memoria de Edwidge Danticat. Estas escenas apuntan a posicionar a la mujer negra como una heredera transgresora de una memoria colectiva. Una mujer que resiste y responde a otros modos de heredar, a otros modos de responder a ese legado que le ha sido asignado. Este ensayo propone una mirada crítica, haciendo énfasis en el papel de la mujer heredera y en su construcción como sujeto autónomo.
Editorial
Authors: Caballero De la Hoz Amilkar
Published: July 2023

Editorial edición No. 34
La ceiba de la memoria y el principio de hospitalidad derridiano
Authors: Lugo Zuleta Farides
Published: July 2023

Este artículo se basa en una comparación entre literatura y filosofía para entender la violencia y la hostilidad en La ceiba de la memoria como producto de la ausencia de hospitalidad, un término tomado de Jacques Derrida. Planteo que todos los personajes de la novela de Burgos Cantor son extranjeros y que aquellos que son subyugados no son considerados como humanos y de ahí el trato que reciben. Son estos tratos los que analizaré como consecuencia de la negación del derecho de hospitalidad que los afrodescendientes en la novela reciben. En esa relación de hospitalidad y hostilidad que se da entre el que recibe al extranjero y este, se invierte en La ceiba de la memoria siendo los españoles influenciados o transformados por personajes como Dominica Orellana y Benkos Bioho. Asimismo, el artículo propone que la obra de Burgos Cantor enúltimas busca subrayar que la tragedia y el dolor padecido por algunos individuos a lo largo de la historia es lo que nos une en la noción de lo humano. En este sentido, la obra nos invita a una reflexión ética en la cual no puede haber otra conclusión que la enorme responsabilidad que tenemos hacia las víctimas del pasado y de nuestro presente.
Albalucía Ángel: «Mi andaregueo por el planeta». Entrevista con “alas”
Authors: Rodríguez Argáez Juan Carlos
Published: July 2023

Enrevista
La devastación del silencio (Acercamiento a la poética de Gabriel Ferrer)
Authors: Pineda Miyer
Published: July 2023

El poeta Gabriel Alberto Ferrer edifica una poética desde el silencio como una resonancia cósmica que resguarda la memoria y la noble luz de las aldeas. La música del río se adentra en el paisaje y restituye lo humano. El ensayo aborda los tres libros publicados por el poeta; y el análisis se enmarca en la hermenéutica de Paul Ricoeur, en diálogo con íconos culturales que median la defensa de la condición humana en tiempos que enaltecen el ruido y la frivolidad. La importancia del ensayo radica en que se propone profundizar en la reflexión sobre el impacto de la obra de los poetas del grupo Si Mañana Despierto, quienes se asumieron como continuadores de la poética-crítica de Mito.
El caribe como comunidad cultural en kamau brathwaite y derek walcott
Authors: Teresa Caisso Claudia
Published: July 2023

El artículo describe  la construcción del Caribe expuesta en “Historia de la voz”(1976)  y “El lenguaje-nación y la poética del acriollamiento” (1991)  del escritor barbadense Kamau Brathwaite. Analiza claves de su teoría cultural como momento  germinal de una crítica profunda ala Modernidady el eurocentrismo. Confronta  aquella perspectiva con matrices culturales acuñadas por Derek Walcott a los efectos de reconocer convergencias y distancias de ambas poéticas en el proceso  de consolidación de la literatura del Caribe anglófono, cuyo pensamiento despliega una confianza profunda en la cultura de la región, la creación de un lenguaje genuino y el cuestionamiento del racismo.  En el campo de los estudios caribeños  este trabajo contribuye  a caracterizar prácticas relevantes de religación  sostenidas por  escritores que consolidaron la literatura del Caribe anglófono.
Representación narrativa de la violencia y el conflicto armado en la obra En el brazo del río de Marbel Sandoval
Authors: Cárdenas Santamaría Jorge Andrés
Published: July 2023

El presente artículo de reflexión trata sobre la configuración de las voces narrativas y su representación de la violencia en la obra En el brazo del río de Marbel Sandoval Ordóñez. En él se busca analizar cómo la memoria y la evocación son los elementos narrativos que permiten dar cuenta del enfrentamiento armado que se vive día a día en zonas de guerra; se intenta a su vez, evidenciar cómo las dos voces femeninas presentes en el relato, permiten caracterizar las implicaciones que trae consigo el acto violento y el testimonio vivencial que subyace en contextos de confrontación bélica.
Tiempo de segar la imagen abismal en la poética de jorge eliécer ordóñez
Authors: Fernando Pineda Miyer
Published: July 2023

El poder de la imagen en el libro Vuelta de campana (1995) del poeta Jorge Ordóñez, ofrece al lector imágenes de su irrupción sobre la fábula kafkiana. De este modo se atestigua la re descripción de los poderes que aplastan al Ser. El escenario conceptual  que respalda el análisis proviene de parámetros ofrecidos por la hermenéutica de Ricoeur en diálogo con planteamientos de Bachelard y de Taylor, sobre el problema de la construcción del Yo moderno a partir de la mediación textual. Sobre estos parámetros de inteligibilidad se procede a recorrer la obra y se ofrecen las impresiones a manera de reflexión sobre el lado secreto de la fábula, una de las poéticas que integran el trabajo del grupo Si Mañana despierto, del que el poeta Ordóñez hace parte y del que aún no existen estudios que lo aborden.
Poetas colombianos de mediados del siglo XX: Un reencuentro con el lenguaje
Authors: Trujillo Paredes Jhon Edwin
Published: July 2023

El presente artículo toma como derrotero la llamada “Generación sin nombre” con el propósito de dilucidar, de acuerdo a la teoría citada, la propuesta poética que caracterizó a ésta reunión de escritores. El autor nuclear del estudio es Henry Luque Muñoz (1944-2005) con una selección de poemas de sus libros Sol cuello cortado (1973), Polen de lejanía (2004) y Escrito con la garra del halcón (2006), para de esta forma entablar un diálogo de interpretaciones junto a los demás poetas que acompañan el presente estudio. De acuerdo a esto, dicho diálogo interpretativo posibilita una hermenéutica del texto poético, un entrecruce de voces y sentidos.
Alegorías del colonialismo: escenas de aprendizaje en la literatura anglo y francoantillana
Authors: Bonfiglio Florencia
Published: July 2023

Al analizar, desde una visión comparativa, el modo en que la literatura antillana ejerce una crítica al imperialismo, despuntan ciertos núcleos de sentido emblemáticos: figuras recurrentes que deconstruyen el mito occidental del Progreso y denuncian la trágica participación de la región –capitalismo y esclavitud mediante– en el proyecto moderno. En esta ocasión me detengo en aquellas escenas de enseñanza/aprendizaje que singularizan la crítica del poder colonial en diversos autores (Aimé Césaire, George Lamming, Kamau Brathwaite, Frankétienne) y textos (poéticos, narrativos, ensayísticos) caribeños; como se verá, estas escenas sirven de modo ejemplar al cuestionamiento de la autoridad cultural (y sus falsos universalismos) desde posiciones subalternas.
El profesor Guillermino y los recuerdos del gemelo Daniel Díaz
Authors: Gómez Tarazona Julián
Published: July 2023

El siguiente artículo de reflexión hace parte de uno de los temas abordados en la tesis titulada: Narraciones eternas, fragmentos del espejo literario de los gemelos Sergio y Daniel Díaz en la novela corta Cuchilla de Evelio Rosero y realiza un análisis literario que la conecta con el cuento Pelea en el parque (Rosero, 1991) y la novela El incendiado (1998) como fragmentos de una trilogía relacionada con el descubrimiento personal, un final abierto y el abatimiento del héroe.
De poetas, narradores e intelectuales
Authors: Vega Bedoya Wilfredo Esteban
Published: July 2023

Con esta entrega la Revista Cuadernos de Literatura del Caribe e Hispanoamérica (De Poetas, Narradores e Intelectuales), el Centro de Estudio e Investigaciones literarias del Caribe (CEILIKA) da continuidad a la consolidación de un espacio dialógico del saber crítico e investigativo del campo literario.
Ártico, una lista de Mike Wilson o la palabra como frágil vínculo de la cordura
Authors: Julio Díaz Ayleen
Published: July 2023

Nieve, un traje de Santa Claus y una voz marcada por una profunda ruptura son los ejes centrales de la narración de Ártico, sexta novela de Mike Wilson y siguiente a la conocida y premiada Leñador (2016) –también  publicada por Fiordo–, en la que el escritor argentino-estadounidense radicado en Chile, sigue apostando con la experimentación literaria a través del uso de nuevos procedimientos de escritura que le posibiliten dar otro aire a las letras latinoamericanas.
Calibán: Es también un “negro bembón”
Authors: García-Arango Lis
Published: July 2023

En este artículo se analiza la temática negrista asumida por Nicolás Guillén como manifestación del proceso de mestizaje físico y espiritual de Cuba. Se profundiza en las principales características de su poesía dentro del contexto de sus creaciones. El texto se fundamenta en los conceptos de mestizaje y transculturación, de Fernando Ortiz, los cuales se evidencian en su poesía. Se señalan los principales vínculos entre la obra de Guillén, que responden, fundamentalmente, a los presupuestos teóricos del ensayista cubano Roberto Fernández Retamar, postulados en su libro Todo Calibán, así como a la oposición civilización-barbarie en el escenario socio-cultural cubano y latinoamericano, donde se desarrolló el poeta.
La tradición oral : elemento de resistencia cultural
Authors: Oviedo Jaramillo Erica Patricia
Published: July 2023

Este artículo analiza el tópico de la tradición oral como elemento de resistencia cultural, evidenciada en los personajes subalternos de algunos cuentos de la obra ¡Cric Crac! (Mil novecientos treinta y siete, Hijos del mar y un muro de fuego) de la escritora haitiana Edwidge Danticant.  Se plantea que los personajes de estos relatos con sentimientos de desarraigo, aun habiendo abandonado sus hogares o estando  en su lugar de origen usan su tradición oral y memoria cultural para resistirse ante la cultura dominante que se impone. En este sentido se convierten en esa otredad que estando en su lugar nativo o en un contexto espacial y cultural diferentes al autóctono, denuncian su inconformidad frente a esta y se mantienen como sujetos propiamente identitarios.
Physics-inspired spatiotemporal-graph AI ensemble for gravitational wave detection
Authors: Huerta Eliu , Tian Minyang , Zheng Huihuo
Published: July 2023

We introduce a novel method for gravitational wave detection that combines: 1) hybrid dilated convolution neural networks to accurately model both short- and long-range temporal sequential information of gravitational wave signals; and 2) graph neural networks to capture spatial correlations among gravitational wave observatories to consistently describe and identify the presence of a signal in a detector network. These spatiotemporal-graph AI models are tested for signal detection of gravitational waves emitted by quasi-circular, non-spinning and quasi-circular, spinning, non-precessing binary black hole mergers. For the latter case, we needed a dataset of 1.2 million modeled waveforms to densely sample this signal manifold. Thus, we reduced time-to-solution by training several AI models in the Polaris supercomputer at the Argonne Leadership Supercomputing Facility within 1.7 hours by distributing the training over 256 NVIDIA A100 GPUs, achieving optimal classification performance. This approach also exhibits strong scaling up to 512 NVIDIA A100 GPUs. We then created ensembles of AI models to process data from a three detector network, namely, the advanced LIGO Hanford and Livingston detectors, and the advanced Virgo detector. An ensemble of 2 AI models achieves state-of-the-art performance for signal detection, and reports seven misclassifications per decade of searched data, whereas an ensemble of 4 AI models achieves optimal performance for signal detection with two misclassifications for every decade of searched data. Finally, when we distributed AI inference over 128 GPUs in the Polaris supercomputer and 128 nodes in the Theta supercomputer, our AI ensemble is capable of processing a decade of gravitational wave data from a three detector network within 3.5 hours, i.e., 2.5×104X faster than real-time. This work underscores the importance of combining advances in AI and supercomputing to address grand challenges in big data physics experiments.
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis
Authors: Bartelt Alexander , Ofoghi Anahita , Kotschi Stefan , Lemmer Imke , Willemsen Nienke , Bayer Batoul , Haas Daniel , Krahmer Natalie , Haberecht Stefanie , Möller Sophie , Krüger Elke
Published: July 2023

Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the transcription factor Nuclear factor erythroid-2 derived,-like-1 (NFE2L1). NFE2L1 regulates proteasome abundance in an adaptive fashion, maintaining protein quality control to secure cellular homeostasis, but the regulation of NFE2L1 during ferroptosis and the role of the ubiquitin-proteasome system (UPS) herein are still unclear. In the present study, using an unbiased proteomic approach charting the specific ubiquitylation sites, we show that induction of ferroptosis leads to recalibration of the UPS. RSL3-induced ferroptosis inhibits proteasome activity and leads to global hyperubiquitylation, which is linked to NFE2L1 activation. As NFE2L1 resides in the endoplasmic reticulum tethered to the membrane, it undergoes complex posttranslational modification steps to become active and induce the expression of proteasome subunit genes. We show that proteolytic cleavage of NFE2L1 by the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is a critical step for the ferroptosis-induced feed-back loop of proteasome function. Cells lacking DDI2 cannot activate NFE2L1 in response to RSL3 and show global hyperubiquitylation. Genetic or chemical induction of ferroptosis in cells with a disrupted DDI2-NFE2L1 pathway diminishes proteasomal activity and promotes cell death. Also, treating cells with the clinical drug nelfinavir, which inhibits DDI2, sensitized cells to ferroptosis. In conclusion, our results provide new insight into the importance of the UPS in ferroptosis and highlight the role of the DDI2-NFE2L1 as a potential therapeutic target. Manipulating DDI2-NFE2L1 activity through chemical inhibition might help sensitizing cells to ferroptosis, thus enhancing existing cancer therapies.
Corrigendum to: Cancer Proteomics: New Horizons and Insights into
Therapeutic Applications
Authors: Jayapalan Jaime Jacqueline , Subramanian Perumal , Abdul-Rahman Puteri Shafinaz
Published: July 2023

Following the publication of the original article [1], the authors reported that the complete grant number of the funding was
omitted. In this correction, the incorrect and correct grant numbers are mentioned. The original publication of this article has
been corrected.

The funding acknowledgement published previously is as follows:

The study was funded by Fundamental Research Grant Scheme (FRGS) by the Ministry of Education, Malaysia, Grant number:
FP067-2018A, Geran Penyelidikan Fakulti by the Faculty of Medicine, University of Malaya, Grant number: GPF001C-
2019, and UGC mid-career award, Grant number: F.19-221/2018 (BSR) dt. 28.03.2018.

We would like to request a revision to one of the funding numbers (in blue) in the funding acknowledgement below:
The correct funding acknowledgement is:

The study was funded by Fundamental Research Grant Scheme (FRGS) by the Ministry of Education, Malaysia, Grant number:
FRGS/1/2018/STG05/UM/02/5, Geran Penyelidikan Fakulti by the Faculty of Medicine, University of Malaya, Grant
number: GPF001C-2019 and UGC mid-career award, Grant number: F.19-221/2018 (BSR) dt. 28.03.2018.

The original article can be found online at: https://www.eurekaselect.com/public/article/109117.