bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations between Unsociability and Peer Problems in Chinese Children and Adolescents: A Meta-Analysis
Authors: Hu Na , Zhang Wen , Haidabieke Aersheng , Wang Jiyueyi , Zhou Nan , Ding Xuechen , Zheng Hong
Published: July 2024

Research has shown that unsociability, reflected as a personal choice, is not necessarily associated with socio-emotional problems in Western countries. However, the associations between unsociability and peer problems are consistently evident in Chinese culture, yet the strength and direction in these associations are mixed. The present study aimed to examine whether unsociability is associated with peer problems and explored the potential moderators among the associations. A meta-analysis was conducted using publications that measured unsociability and peer problems. A total of 21 articles involving 43 effect sizes from 12,696 Chinese children and adolescents were included. The results revealed that (1) unsociability was positively associated with peer problems (r = 0.32, p < 0.001) among children and adolescents. (2) Informants (i.e., self-reports, peer nominations, teacher ratings, and parent ratings) and living areas (i.e., urban, suburban, and rural areas) significantly moderated the associations between unsociability and peer problems. Specifically, the associations were stronger for peer-nominated unsociability, self-reported peer problems, and samples in suburban areas. These findings shed light on unsociability linked to higher levels of peer problems among Chinese children and adolescents. Still, the influences are unique to peer problems and moderated by both data sources and environmental factors.
Research on Collision Restitution Coefficient Based on the Kinetic Energy Distribution Model of the Rocking Rigid Body within the System of Mass Points
Authors: Mao Qiuyu , Deng Tongfa , Shen Botan , Wang Yuexin
Published: July 2024

Rocking structures exhibit significant collapse resistance during earthquakes. In studies of rocking rigid bodies, the collision restitution coefficient is typically determined based on the classical model of the rocking rigid bodies. However, during the rocking process, the collision restitution coefficient, influenced by the uncontrollable error in collision energy dissipation between the rigid body and the ground, indirectly impacts the final results of the equations of motion. Therefore, the rationality and reliability of the collision restitution coefficient are crucial for seismic analysis of rocking rigid bodies and self-centering members. This paper introduces a phasic energy dissipation and kinetic energy redistribution model specifically designed for the rocking rigid body within the system of mass point. This model divides the collision into three distinct stages, incorporating energy dissipation considerations in the first two stages to calculate the total kinetic energy of the rigid body. In the third stage, the remaining kinetic energy is redistributed to precisely determine the analytical solution for the collision restitution coefficient of an ideal, homogeneous rectangular rigid body during collision. Lastly, the validity and reliability of the proposed model are confirmed through comparisons with experimental data.
Study on Mechanical Properties of Nano-TiC- and Nano-SiO2-Modified Basalt Fiber Concrete
Authors: Yang Xin , Wang Zhengjun , Wang Xinzheng , Wen Yajing , Du Yingxin , Ji Fengchun
Published: July 2024

The load-bearing capacity of a building is influenced by the strength of the concrete. However, when faced with complex environments, ordinary concrete is not always adequate. The strength of concrete can be enhanced by incorporating additives into it. At this point, the study of adding basalt fiber (BF) and nano-SiO2 (NS) to concrete is pretty advanced. Still, research on the incorporation of nano-TiC (NT) into concrete is limited. In order to study the effect of NT, BF, and NS on the strength of concrete, in this paper, these materials were incorporated into concrete and NSF concrete was made by semi-dry mixing. And the concrete was analyzed for slump, compressive strength, splitting tensile strength, flexural strength, and modulus of elasticity. The optimization of the mechanical characteristics of concrete was conducted using response surface methodology (RSM), and the microstructure of concrete was used for analysis by scanning electron microscopy (SEM). To develop a thirst function optimization model based on NSF concrete, parallel experiments were used to verify the accuracy of the optimization results. The research findings show that NS, NT, and BF reduced the slump of concrete. Adding NT, NS, and BF in moderate amounts can enhance the mechanical characteristics of the concrete. The material’s optimal proportions for mixing were 0.85% for NT, 0.11% for BF, and 1.94% for NS. The optimized concrete has a maximum error of 9.03% in compressive strength, 9.30% in split tensile strength, and 9.82% in flexural strength.
Analysis of the Bearing Capacity of Concrete-Filled Thin-Walled Square Steel Tubes with Helical Stiffening Based on Local Buckling
Authors: Tian Penggang , Wang Zhenshan , Wang Kai , Niu Jianhui , Xie Zhixun , Liu Kangning
Published: July 2024

To address the issue of local buckling in thin-walled steel tube concrete columns, a form of helical stiffening ribs was proposed. Axial compression tests were conducted on five sections of square steel tube concrete column specimens. The research revealed that, compared to ordinary steel tube concrete columns, the axial compression bearing capacity and deformation capacity of steel tube concrete columns with helical rib constraints increased by 18.5% and 7.7%, respectively. The helical ribs effectively enhanced the buckling resistance of the thin-walled steel tube concrete components. The failure pattern of this new type of component was characterized by diagonal cracks in the encased concrete aligning with the direction of the helical ribs, and the buckling of the steel tube walls was concentrated between the helical stiffening ribs. Based on the experiments, an analysis of the buckling performance of thin-walled steel tubes with helical rib constraints was conducted, and this was incorporated into the bearing capacity calculation. The test, simulation, and theoretical calculations showed that the bearing capacity error of the composite columns for each specimen was within 10%. Ultimately, a formula for the critical buckling bearing capacity of the helical rib steel tubes was proposed. The research findings provide a foundation for the engineering application of this new type of component.
A Study of the Shear Behavior of Concrete Beams with Synthetic Fibers Reinforced with Glass and Basalt Fiber-Reinforced Polymer Bars
Authors: Duarte Isabela Oliveira , Forti Nadia Cazarim da Silva , Pimentel Lia Lorena , Jacintho Ana Elisabete Paganelli Guimarães de Avila
Published: July 2024

The use of synthetic materials with high corrosion resistance in a concrete matrix yields structures that are more durable and suitable for use in aggressive environments, eliminating the need for frequent maintenance. Examples of such materials include glass (GFRP) and basalt (BFRP) fiber-reinforced polymer bars (FRP). Due to the low modulus of elasticity of these bars, concrete elements reinforced with FRP longitudinal rebars tend to exhibit cracks with wider openings and greater depths compared to those reinforced with steel rebars, which diminishes the element’s shear resistance. The addition of discontinuous fibers into the concrete aims to maintain stress transfer across the cracks, thereby enhancing the shear capacity and ductility of FRP-reinforced structures. This study evaluates the impact of fiber addition on the shear resistance of concrete beams reinforced with FRP rebars. An experimental investigation was conducted, focusing on the partial and complete substitution of stirrups with polypropylene macro fibers in concrete beams reinforced with FRP longitudinal rebars and stirrups. This research examined beams reinforced with glass (GFRP) and basalt (BFRP) fiber-reinforced polymer bars. For the initial set of beams, all stirrups were replaced with synthetic macro fibers. In the subsequent set, macro fibers were added to beams with insufficient stirrups. Although the complete replacement of GFRP and BFRP stirrups with polypropylene macro fibers did not alter the brittle shear failure mode, it did enhance the shear resistance capacity by 78.5% for GFRP-reinforced beams and 60.4% for BFRP-reinforced beams. Furthermore, the addition of macro fibers to beams with insufficient stirrups, characterized by excessive spacing, changed the failure mode from brittle shear to pseudo-ductile flexural failure due to concrete crushing. In such instances, the failure load increased by 18.8% for beams with GFRP bars and 22.8% for beams with BFRP bars.
Exploring Briefing Processes across Mature Markets of Public–Private Partnership (PPP) Projects: Comparative Insights and Important Considerations
Authors: Al Saadi Rauda , Abdou Alaa
Published: July 2024

The primary objective of this research paper is to conduct a comprehensive investigation into the process of developing briefs for Public–Private Partnership (PPP) projects. The study aims to outline the fundamental stages, standard processes, and critical decision points involved in this process. This is achieved through a comparative analysis of briefing frameworks used in three countries that are among the top in the PPP Market Maturity chart: The United Kingdom, Australia, and Canada. The paper discusses the stages and decision points within these countries’ briefing processes, highlighting their challenges, similarities, and differences. It emphasizes the fundamental role of effective communication and coordination in PPP projects, which involve multiple stakeholders. By examining these interconnected activities and analyzing the phases, stages, and key processes constituting the briefing process, the study provides valuable insights into the PPP briefing processes in these nations. The paper concludes by proposing a conceptual process framework for brief development in PPP projects, which will be further tailored for adaptation in the PPP market in the United Arab Emirates.
Preserving the Past: Investigating Zanzibar’s Ancient Construction Materials for Sustainable Heritage Conservation
Authors: Ali Bimkubwa Seif , Castro Juan Jose , Omi Shogo , Nazimi Karishma
Published: July 2024

The architectural treasures of Zanzibar’s Stone Town, echoing the footprints of ancient civilizations, face an imminent threat of heritage loss due to accelerated material degradation. This underscores the urgent need for an intrinsic examination of building material properties to enhance existing restoration guidelines and effectively safeguard the historical legacy. This study is the first significant step for the extensive procurement of samples to investigate the physical, mechanical, and chemical properties of deteriorating coral stones, mortar, and wood material of Zanzibar’s Stone Town. The results indicate considerable water absorption and varying porosity and densities, highlighting the significant water retention and susceptibility of marine environmental factors. The compressive strength (CS) for coral stone, mortar, and wood falls under 7.6 MPa to 12.2 MPa, 0.5 to 0.9 MPa, and 52.9 to 69.3 MPa, revealing the heterogenous characteristics across the samples. The flexural strength of coral stone and wood was found to be from 2.0 MPa to 3.4 and 72.1 MPa to 98.6 MPa, indicating a high susceptibility to breakage and fracture. Meanwhile, Ultra Pulse Velocity (UPV) averages 1668 to 2070 m/s, revealing void ranges in building materials. Chemical analysis, including X-ray diffraction (XRD) and X-ray fluorescence (XRF), demonstrates higher CaO content in coral stone and mortar, with the predominant mineral aragonite indicating vulnerability to rapid chemical attacks. These results can significantly contribute to future modifications and improvements in restoration guidelines by facilitating the identification and utilization of appropriate materials’ properties. This ensures a high level of compatibility and promotes the sustainable conservation of Stone Town’s architectural heritage.
Application of Smart Modelling Framework for Traditional Wooden Architecture
Authors: Zhang Jialong , Wang Zijun , Wang Wei
Published: July 2024

Preserving ancient buildings can be improved using Building Information Modelling (BIM) models created from high-quality point-cloud data. The problems arise from the need for automatic extraction of the characteristics required to meet various security criteria from a high-fidelity point cloud. BIM for Traditional Wooden Architecture (TWA) constructions requires collaboration across various research fields. Two crucial concerns are needed to overcome the current gap and enhance the use of BIM: an automated model for the major components that smartly combines historical information and a Smart Modelling Framework (SMF) to represent these components. First, a parametric model for the usual components, highlighting similarities and properties, was created using a TWA structure as the basis. The next step is creating an automated modelling approach to determine the component type and hidden dimensions automatically. Conservation initiatives for traditional wooden structures will benefit greatly from this research results. The experimental results demonstrate that the suggested technique accomplishes better efficiency, reliability, and effectiveness than other existing technologies.
Quantifying the Influence of Different Block Types on the Urban Heat Risk in High-Density Cities
Authors: Zou Binwei , Fan Chengliang , Li Jianjun
Published: July 2024

Urbanization and climate change have led to rising urban temperatures, increasing heat-related health risks. Assessing urban heat risk is crucial for understanding and mitigating these risks. Many studies often overlook the impact of block types on heat risk, which limits the development of mitigation strategies during urban planning. This study aims to investigate the influence of various spatial factors on the heat risk at the block scale. Firstly, a GIS approach was used to generate a Local Climate Zones (LCZ) map, which represents different block types. Secondly, a heat risk assessment model was developed using hazard, exposure, and vulnerability indicators. Thirdly, the risk model was demonstrated in Guangzhou, a high-density city in China, to investigate the distribution of heat risk among different block types. An XGBoost model was used to analyze the impact of various urban spatial factors on heat risk. Results revealed significant variations in heat risk susceptibility among different block types. Specifically, 33.9% of LCZ 1–4 areas were classified as being at a high-risk level, while only 23.8% of LCZ 6–9 areas fell into this level. In addition, the pervious surface fraction (PSF) had the strongest influence on heat risk level, followed by the height of roughness elements (HRE), building surface fraction (BSF), and sky view factor (SVF). SVF and PSF had a negative impact on heat risk, while HRE and BSF had a positive effect. The heat risk assessment model provides valuable insights into the spatial characteristics of heat risk influenced by different urban morphologies. This study will assist in formulating reasonable risk mitigation measures at the planning level in the future.
Compressive Creep Test on Fiber-Reinforced Ultra-High Performance Concrete: Effects of Strain Measuring Method, Specimen Size, Sustained Load Intensity, and Fiber Length
Authors: Park Hyun-Myo , Ryu Seung-Ryong , Kwon Oh Kyun , Yang Jun-Mo
Published: July 2024

To solve the difficulties in applying the compressive creep test method for normal concrete to UHPC and to verify the validity of the recently proposed ASTM C 1856 standard test method, this study performed compressive creep tests on UHPC with the variables of specimen size, sustained load intensity, fiber length, and strain measuring method. The experimental results show that the strain meter method using the standard rod had limitations due to the error in the verification process using the standard rod and the observation error of the measurer, and a sustained load intensity of 15% to 40% of the actual compressive strength is preferable. It was found that it is possible to perform a compressive creep test for UHPC using a specimen with a size of ϕ75 mm or more, and the fiber length did not affect the creep behavior of the UHPC up to 19.5 mm. As a result of comparing the UHPC creep test results with the creep prediction model, the B3 model was found to most accurately predict the UHPC creep behavior. The creep coefficient pattern of the B3 model was very similar to the measured results and well reflects the effects of the mixing ratio and compressive strength of UHPC.
CO2 Concentration Assessment for Infection Monitoring and Occupancy Analysis in Tanzanian COVID-19 Isolation Centers
Authors: Karumuna Benson Vedasto , Hao Long
Published: July 2024

Monitoring of IAQ is one of the foundations of the preventative actions prompted by the worldwide recognition of COVID-19 transmission. The measurement of CO2 has emerged as one of the most popular, dependable, and easy ways to indirectly evaluate the state of indoor air renewal. Reducing the risk of respiratory diseases transmitted by aerosols is attainable through implementing and validating prevention measures made possible by CO2 control. Isolation centers are like health facilities in that they are linked to IAQ, and the presence of natural ventilation can significantly improve the circulation of fresh air, which speeds up the removal of contaminants. This is true even though healthcare facilities are among the environments with the highest rate of COVID-19 propagation. Our investigation revealed, however, that no substantial critical data on air quality in Tanzanian isolation centers is presently available. The process of metabolic CO₂ creation and accumulation within health isolation center cubicles was investigated in this study. Crucially, we suggest comparing settings under various conditions using the indicator ppm/patient. In this research, we experimentally assessed the value of changing a few HVAC system characteristics. We looked at the data to see how well the filtration system worked concerning the submicron particle concentration. Study recommendations for CO2 detectors and ways to reduce infection risk in shared isolation center cubicles are provided. We also show the correlation between particle size and CO2 concentration, the correlation between CO2 concentration derivatives and air volume presented per patient in isolation cubicles, the correlation between patient occupancy and CO2 concentration levels in isolation cubicles, and how to improve air quality by adjusting the patient’s bed position. The study also found that for exposure lengths of two to three hours, a typical hospital cubicle with fifty to one hundred people should have an average interior CO₂ value of less than 900 ppm. Carers’ length of stay in the hospital substantially impacted the permissible CO2 concentration. By establishing a connection between indoor air monitoring and healthcare goals, this study will aid in determining the feasibility of establishing regulations for interior CO2 content depending on occupancy settings, strengthening preventive efforts against COVID-19. In the post-pandemic era, it will be essential to find ways to make health facilities air cleaner so that infectious diseases cannot spread in the future.
Incidence and Risk Factors for Arterial Thrombosis in Patients with Acute Leukemia and Lymphoid Malignancies: A Retrospective Single-Center Study
Authors: Hellman Jenna , Chaireti Roza
Published: July 2024

Introduction: The treatment of patients with hematological malignancies and acute arterial thrombosis (ATE) is challenging due to the risk of bleeding complications during treatment. Data on the incidence and risk factors for ATE in this group are very limited. Aims: We aimed to evaluate the incidence and risk factors for ATE in patients with acute leukemia (AL) and lymphoid malignancies. Material and Methods: Patients with acute leukemia (AL), lymphoid malignancies, and ATE diagnosed following cancer diagnosis, who were treated and followed at the Department of Hematology, Karolinska University Hospital, 2005–2020, were candidates for inclusion in this study. Retrospective data on malignancy, ATE, and risk factors were collected. Results: No differences in either the 15-year incidence of ATE (1.4%) nor in the risk factors for cardiovascular disease (CVD) between patients with AL and lymphoid malignancies and ATE were found. ATE at diagnosis was more frequent in patients with AL and lymphoid malignancies (excluding chronic lymphatic leukemia, CLL). Conclusions: Patients with AL and lymphoid malignancies have a similar risk of ATE when compared to each other and the general population, regardless of platelet levels. No difference could be found in the presence of CVD risk factors between patients with AL and lymphoid malignancies presenting with ATE.
A Novel Prognostic Indicator for Immunotherapy Response: Lymphocyte-to-Albumin (LA) Ratio Predicts Survival in Metastatic NSCLC Patients
Authors: Yildirim Sedat , Dogan Akif , Akdag Goncagul , Cavdar Eyyup , Kinikoglu Oguzcan , Oksuz Sila , Yildiz Hacer Sahika , Kucukoz Uzun Aysun , Isik Deniz , Surmeli Heves , Basoglu Tugba , Sever Ozlem Nuray , Odabas Hatice , Yildirim Mahmut Emre , Turan Nedim
Published: July 2024

Objective: Immunotherapies are commonly employed for the treatment of non-small-cell lung cancer (NSCLC). However, predictive biomarkers still need to be improved to predict responses to these agents. The lymphocyte–albumin (LA) laboratory index has not been evaluated before in this patient group. The aim of this study was to analyze the relation between the LA index and the survival rate of metastatic NSCLC patients who had immunotherapy after at least one round of chemotherapy. Methods: The research included 227 patients diagnosed with metastatic NSCLC, who were administered nivolumab after at least one round of chemotherapy. The LA index was calculated by multiplying lymphocyte count and albumin concentration. The optimal threshold values for the index were established by the examination of the ROC curve for both overall survival (OS) and progression-free survival (PFS). Oncological data were obtained retrospectively from patient files, and survival analyses were performed. Results: The median follow-up was 7.9 months. Progression was observed in 129 (56.9%) patients. A total of 97 (42.7%) patients died during the follow-up. The cutoff values of the LA index to predict OS and PFS were determined as 52.87 and 57.67, respectively. The low-LA group had significantly lowered OS and PFS compared to the high-LA group. LA was found to be an independent prognostic factor for PFS (hazard ratio 4.47; 95% confidence interval, 2.73–7.34; p < 0.001) and OS (hazard ratio 6.24; 95% confidence interval, 3.46–11.25; p < 0.001) in the multivariate regression analysis. Conclusions: In this study, we observed that the LA index independently predicts OS and PFS in immunotherapy-treated metastatic NSCLC patients. Its ease of application, low cost, and noninvasive nature make it a potential guide for clinicians in predicting treatment responses and survival.
Investigating the Radiobiological Response to Peptide Receptor Radionuclide Therapy Using Patient-Derived Meningioma Spheroids
Authors: Reuvers Thom G. A. , Grandia Vivian , Brandt Renata M. C. , Arab Majd , Maas Sybren L. N. , Bos Eelke M. , Nonnekens Julie
Published: July 2024

Peptide receptor radionuclide therapy (PRRT) using 177Lu-DOTA-TATE has recently been evaluated for the treatment of meningioma patients. However, current knowledge of the underlying radiation biology is limited, in part due to the lack of appropriate in vitro models. Here, we demonstrate proof-of-concept of a meningioma patient-derived 3D culture model to assess the short-term response to radiation therapies such as PRRT and external beam radiotherapy (EBRT). We established short-term cultures (1 week) for 16 meningiomas with high efficiency and yield. In general, meningioma spheroids retained characteristics of the parental tumor during the initial days of culturing. For a subset of tumors, clear changes towards a more aggressive phenotype were visible over time, indicating that the culture method induced dedifferentiation of meningioma cells. To assess PRRT efficacy, we demonstrated specific uptake of 177Lu-DOTA-TATE via somatostatin receptor subtype 2 (SSTR2), which was highly overexpressed in the majority of tumor samples. PRRT induced DNA damage which was detectable for an extended timeframe as compared to EBRT. Interestingly, levels of DNA damage in spheroids after PRRT correlated with SSTR2-expression levels of parental tumors. Our patient-derived meningioma culture model can be used to assess the short-term response to PRRT and EBRT in radiobiological studies. Further improvement of this model should pave the way towards the development of a relevant culture model for assessment of the long-term response to radiation and, potentially, individual patient responses to PRRT and EBRT.
Extended Synaptotagmins 1 and 2 Are Required for Store-Operated Calcium Entry, Cell Migration and Viability in Breast Cancer Cells
Authors: Redondo Pedro C. , Lopez Jose J. , Alvarado Sandra , Jardin Isaac , Nieto-Felipe Joel , Macias-Diaz Alvaro , Jimenez-Velarde Vanesa , Salido Gines M. , Rosado Juan A.
Published: July 2024

Extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER)-associated proteins that facilitate the tethering of the ER to the plasma membrane (PM), participating in lipid transfer between the membranes and supporting the Orai1–STIM1 interaction at ER–PM junctions. Orai1 and STIM1 are the core proteins of store-operated Ca2+ entry (SOCE), a major mechanism for Ca2+ influx that regulates a variety of cellular functions. Aberrant modulation of SOCE in cells from different types of cancer has been reported to underlie the development of several tumoral features. Here we show that estrogen receptor-positive (ER+) breast cancer MCF7 and T47D cells and triple-negative breast cancer (TNBC) MDA-MB-231 cells overexpress E-Syt1 and E-Syt2 at the protein level; the latter is also overexpressed in the TNBC BT20 cell line. E-Syt1 and E-Syt2 knockdown was without effect on SOCE in non-tumoral MCF10A breast epithelial cells and ER+ T47D breast cancer cells; however, SOCE was significantly attenuated in ER+ MCF7 cells and TNBC MDA-MB-231 and BT20 cells upon transfection with siRNA E-Syt1 or E-Syt2. Consistent with this, E-Syt1 and E-Syt2 knockdown significantly reduced cell migration and viability in ER+ MCF7 cells and the TNBC cells investigated. To summarize, E-Syt1 and E-Syt2 play a relevant functional role in breast cancer cells.
Structural Effect of Cu-Mn/Al2O3 Catalysts on Enhancing Toluene Combustion Performance: Molecular Structure of Polyols and Hydrothermal Treatment
Authors: Li Junjie , Chen Wenjing , Xu Chenghua , Hou Xiaoxiao , Hu Xiaodong
Published: July 2024

This study presents a series of Cu-Mn/Al2O3 catalysts prepared by the polyol method to improve the toluene combustion process. The catalytic activity evaluation results showed that the different polyols have a great influence on catalyst activity, in which the catalyst prepared with glycerol through a hydrothermal reaction at 90 °C displayed the highest catalytic activity. The lowest T90 and T50 values could be achieved by CMA-GL-90 with 260 and 237 °C, respectively. Moreover, the XRD and BET results showed that the hydrothermal treatment was more favorable with Cu-Mn crystal formation, and an abundance of mesopores remained in all catalysts with a high specific surface area from 94.37 to 123.03 m2·g−1. The morphology analysis results by SEM and TEM indicated that employing glycerol coupled with hydrothermal treatment at 90 °C could enhance the formation of CuMn2O4 spinel. The toluene catalytic combustion mechanism of Cu-Mn/Al2O3 catalysts was discussed based on XPS and H2-TPR, and a high atomic ratio of Mn3+ could be obtained with 51.03%, and the ratio of Oads/Olatt also increased to 2.85 in CMA-GL-90. The increase in Mn3+ species and oxygen vacancies on the surface of catalysts exhibited excellent activity and stability for toluene combustion. These findings offer valuable insights for optimizing the design and application of Cu-Mn/Al2O3 catalysts in addressing the catalytic oxidation reactions of organic volatile compounds.
Nanocatalysts for the Degradation of Refractory Pollutants
Authors: Guo Sheng , Liu Yazi , Li Jun
Published: July 2024

The rapid development of industrialization has resulted in the excessive emission of hazardous contaminants into our water and air resources, adversely affecting both health and the environment [...]
Mixed Oxides as Catalysts for the Condensation of Cyclohexanol and Benzaldehyde to Obtain a Claisen–Schmidt Condensation Product
Authors: Stoylkova Tanya , Stanimirova Tsveta , Chanev Christo D. , Petrova Petya , Metodieva Kristina
Published: July 2024

Acid–base M2+MgAlO and M2+AlO mixed oxides (where M2+ = Mg, Cu, Co, Zn, and Ni) were obtained by thermal decomposition of the corresponding layered double hydroxide (LDH) precursors and used as catalysts for cyclohexanol and benzaldehyde condensation under solvent-free conditions. The catalysts were characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF), scanning electron microscopy (SEM), and temperature-programmed desorption of CO2 (TPD-CO2). Gas chromatography–mass spectroscopy (GC/MS) was used for the identification and quantification of the product mixtures. In the reaction of cyclohexanol and benzaldehyde on M2+MgAlO and MgAlO catalysts, a 2,6-dibenzylidene-cyclohexanone was obtained as the main product as a result of consecutive one-pot dehydrogenation of cyclohexanol to cyclohexanone and subsequent Claisen–Schmidt condensation. In the reaction mixture obtained in the presence of NiAlO, CoAlO, and ZnAlO catalysts, a cyclohexyl ester of 6-hydroxyhexanoic acid was detected together with the main product. This is most likely a by-product obtained after the oxidation, ring opening, and subsequent esterification of the cyclohexanol.
The Multiple Roles of Lactate in the Skeletal Muscle
Authors: Bartoloni Bianca , Mannelli Michele , Gamberi Tania , Fiaschi Tania
Published: July 2024

Believed for a long time to be merely a waste product of cell metabolism, lactate is now considered a molecule with several roles, having metabolic and signalling functions together with a new, recently discovered role as an epigenetic modulator. Lactate produced by the skeletal muscle during physical exercise is conducted to the liver, which uses the metabolite as a gluconeogenic precursor, thus generating the well-known “Cori cycle”. Moreover, the presence of lactate in the mitochondria associated with the lactate oxidation complex has become increasingly clear over the years. The signalling role of lactate occurs through binding with the GPR81 receptor, which triggers the typical signalling cascade of the G-protein-coupled receptors. Recently, it has been demonstrated that lactate regulates chromatin state and gene transcription by binding to histones. This review aims to describe the different roles of lactate in skeletal muscle, in both healthy and pathological conditions, and to highlight how lactate can influence muscle regeneration by acting directly on satellite cells.
Molecular Understanding of the Surface-Enhanced Raman Spectroscopy Salivary Fingerprint in People after Sars-COV-2 Infection and in Vaccinated Subjects
Authors: Rodà Francesca , Gualerzi Alice , Picciolini Silvia , Forleo Luana , Mangolini Valentina , Mancuso Roberta , Agostini Simone , Rossetto Rudy Alexander , Pierucci Paola , Banfi Paolo Innocente , Bedoni Marzia
Published: July 2024

The rapid spread of SARS-COV-2 and the millions of worldwide deaths and hospitalizations have prompted an urgent need for the development of screening tests capable of rapidly and accurately detecting the virus, even in asymptomatic people. The easy collection and the biomarker content of saliva, together with the label-free and informative power of surface-enhanced Raman spectroscopy (SERS) analysis have driven the creation of point-of-care platforms capable of identifying people with COVID-19. Indeed, different salivary fingerprints were observed between uninfected and infected people. Hence, we performed a retrospective analysis of SERS spectra from salivary samples of COVID-19-infected and -vaccinated subjects to understand if viral components and/or the immune response are implicated in spectral variations. The high sensitivity of the proposed SERS-based method highlighted the persistence of molecular alterations in saliva up to one month after the first positive swab, even when the subject tested negative for the rapid antigenic test. Nevertheless, no specific spectral patterns attributable to some viral proteins and immunoglobulins involved in COVID-19 infection and its progression were found, even if differences in peak intensity, presence, and position were observed in the salivary SERS fingerprint.
SERS Substrate Based on Ag Nanoparticles@Layered Double Hydroxide@graphene Oxide and Au@Ag Core–Shell Nanoparticles for Detection of Two Taste and Odor Compounds
Authors: Lao Zhixiong , Zhong Mingmin , Liang Yin , Tan Jianrong , Liang Xiaoyan , Xie Wucheng , Liang Yong , Wang Jun
Published: July 2024

Sulfide organics and phenols are ubiquitous in freshwater lakes all over the world. As two taste and odor (T and O) compounds, they are harmful to the environment and human body. The existing detection methods for T and O compounds mainly include sensory analysis and gas-phase mass spectrometry, which are cumbersome and time-consuming. Herein, a method for the simultaneous and rapid detection of two T and O compounds (methyl sulfide and 2,4-di-tert-butylphenol) based on surface-enhanced Raman spectroscopy (SERS) is firstly developed. The SERS substrate was prepared by coating Ag nanoparticles (Ag NPs), layered double hydroxide (LDH), and graphene oxide (GO) on the surface of an Ag-coated Au nanoparticle (Au@Ag NP) substrate. Under optimal conditions, this SERS substrate possessed low detection limits of 1.53 ppm for methyl sulfide and 0.39 ppm for 2,4-di-tert-butylphenol. In addition, it took only 20 min to complete the detection using this method, without complex sample pretreatment. Furthermore, it was successfully applied to simultaneously detect methyl sulfide and 2,4-di-tert-butylphenol in actual water samples and had good application prospects for the rapid detection of T and O compounds in water.
The Theory and Computation of the Semi-Linear Reaction–Diffusion Equation with Dirichlet Boundaries
Authors: Chin Pius W. M.
Published: July 2024

In this article, we study the semi-linear two-dimensional reaction–diffusion equation with Dirichlet boundaries. A reliable numerical scheme is designed, coupling the nonstandard finite difference method in the time together with the Galerkin in combination with the compactness method in the space variables. The aforementioned equation is analyzed to show that the weak or variational solution exists uniquely in specified space. The a priori estimate obtained from the existence of the weak or variational solution is used to show that the designed scheme is stable and converges optimally in specified norms. Furthermore, we show that the scheme preserves the qualitative properties of the exact solution. Numerical experiments are presented with a carefully chosen example to validate our proposed theory.
Preliminary Experience with a Cleansing Mousse and a Non-Steroidal Emulsion for the Prevention and Treatment of Acute Radiation Dermatitis in Breast Cancer Patients Undergoing Adjuvant Radiotherapy
Authors: Viola Anna , Martorana Emanuele , Zagardo Valentina , Ferini Gianluca
Published: July 2024

Background: Radiation dermatitis (RD) is the most frequent side effect in patients undergoing adjuvant radiotherapy (RT) for breast cancer. Despite the skin-sparing benefits of new RT techniques, most patients develop RD. There is currently no standard treatment to prevent and soothe RD, which is generally managed with emollients, moisturizers, or corticosteroids. We conducted a prospective observational study to evaluate the rate and grade of RD with the application of a cleansing mousse and a non-steroidal emulsion during the adjuvant RT program in patients with breast cancer submitted to surgery. Materials and Methods: A cleansing mousse containing vegetable glycerin (12%), phytoextract of chamomile (0.5%), yarrow phytoextract (0.5%), sweet almond (0.1%), Oenothera oil (0.1%), and rice protein hydrolyzate (0.1%), and an emulsion containing micronized zinc oxide (3.7%), rapeseed phytosterols (1.7%), aloe (0.5%), 18-beta glycyrrhetinic acid (0.5%), alpha bisabolol (0.5%), and zanthalene (0.5%) were offered to breast cancer patients undergoing adjuvant RT to prevent the onset of RD and mitigate its severity. These specific ingredients were selected for their well-known anti-inflammatory, antioxidant, and moisturizing properties. Skin toxicities were recorded photographically and graded according to the RTOG scoring system. Results: From March 2023 to July 2023, a total of 24 patients with a median age of 59 years (range 42–75) were enrolled. Halfway through the RT treatment, 20 patients (83.3%) had G0 skin toxicity, three (12.5%) G1, one (4.2%) G2. None showed G3–G4 toxicity. At the end of RT, seven patients (29.2%) exhibited G0 skin toxicity, 14 (58.3%) G1, two (8.3%) G2, one (4.2%) G3. No patient developed G4 toxicity. Fifteen days after the end of RT, 13 patients (54.2%) had G0 skin toxicity, 10 (41.1%) G1, one (4.2%) G2, with none showing G3–G4 toxicity. Conclusions: Our data suggest that the tested topicals might be an effective option for preventing and alleviating RD. Further prospective randomized studies are needed to confirm our findings.
Recovery of Intertidal Mussel Stands Three Years after the Severe 2021 Heatwave in British Columbia, Canada
Authors: Scrosati Ricardo A.
Published: July 2024

In the early summer of 2021, an intense heatwave killed millions of intertidal mussels in British Columbia, Canada. Using photographs taken three years later (June 2024), this article provides visual evidence of active recovery of intertidal mussel stands in the Vancouver region, revealing the resilience of these intertidal systems. Future monitoring should evaluate their ability for long-term persistence in light of the ongoing climate change, which is expected to increase the frequency and intensity of heatwaves.
An Updated Taxonomic Appraisal of Narcissus (Amaryllidaceae) in the Maltese Islands
Authors: Mifsud Stephen , Lanfranco Sandro
Published: July 2024

A previous study of Narcissus species on the Maltese Islands had suggested the existence of a natural hybridogenous species. A fresh study on Narcissus in Malta was conducted in 2021 and 2023 with the primary aim of studying the previously reported populations of intermediate forms and to update the taxonomy of Narcissus in Malta. Four main taxa of native species were identified: N. deficiens, two distinct morphotypes of N. tazetta, and a new hybrid species. The species identified as N. deficiens replaces records of N. serotinus and N. obsoletus. One of the two morphotypes (“autumn-flowering”) is now combined as subsp. aequilimbus (previously described from Maltese material as Hermione aequilimba) and the other one (“spring-flowering”) corresponds to subsp. tazetta. The new hybrid is derived from N. deficiens and N. tazetta and is named N × briffae. This hybrid was previously incorrectly reported as N. elegans. Detailed morphometric analysis and ecological data justify these new taxonomic appraisals. A dichotomous identification key for eight Narcissus taxa (including non-native ones) is provided to facilitate the identification of the occurring and doubtful species recorded on the Maltese Islands.
Diversity and Conservation of Rodents in Saudi Arabia
Authors: Al Malki Khaled Ahmad , Al Ghamdi Abdul Rahman , Shuraim Faisal , Neyaz Farah , Al Boug Ahmad , Al Jbour Sharif , Angelici Francesco M. , Amr Zuhair S.
Published: July 2024

The rodents of Saudi Arabia consist of twenty species and twelve genera within four families (Gliridae, Dipodidae, Muridae, and Hystricidae). Details on the past and present distribution of the rodents were included, along with available data on their habitat preference and biology. The eastern central part of Saudi Arabia, covering the Tuwiq mountains plateau, including the vicinity of Riyadh, hosts the highest number of rodent species. An analysis of the rodent fauna of Saudi Arabia revealed that they have four major zoogeographical affinities: Palaearctic–Oriental (one species), Afrotropical–Palaearctic (six species), Palaearctic (four species), endemic to Saudi Arabia and Yemen (three species), Afrotropical–Palaearctic–Oriental (three species), and three cosmopolitan species. According to the National Red List, the Euphrates Jerboa, Scarturus euphraticus, is listed as endangered, the Indian Crested Porcupine, Hystrix indica, as near threatened, three further species as data-deficient, while the rest are considered least concern.
Outcome of Endoscopic Resection of Rectal Neuroendocrine Tumors ≤ 10 mm
Authors: Rossi Roberta Elisa , Terrin Maria , Carrara Silvia , Maselli Roberta , Bertuzzi Alexia Francesca , Uccella Silvia , Lania Andrea Gerardo Antonio , Zerbi Alessandro , Hassan Cesare , Repici Alessandro
Published: July 2024

Background and aim: Guidelines suggest endoscopic resection for rectal neuroendocrine tumors (rNETs) < 10 mm, but the most appropriate resection technique is unclear. In real-life clinical practice, the endoscopic removal of unrecognized rNETs can take place with “simple” techniques and without preliminary staging. The aim of the current study is to report our own experience at a referral center for both neuroendocrine neoplasms and endoscopy. Methods: Retrospective analyses of polypectomies were performed at the Humanitas Research Hospital for rNETs (already diagnosed or previously unrecognized). Results: A total of 19 patients were included, with a median lesion size of 5 mm (range 3–10 mm). Only five lesions were suspected as NETs before removal and underwent endoscopic ultrasound (EUS) before resection, being removed with advanced endoscopic techniques. Unsuspected rNETs were removed by cold polypectomy in eleven cases, EMR in two, and biopsy forceps in one. When described, the margins were negative in four cases, positive in four (R1), and indeterminate in one. The median follow-up was 40 months. A 10 mm polypoid lesion removed with cold snare polypectomy (G2 R1) needed subsequent surgery. Eighteen patients underwent EUS after a median time of 6.5 months from resection. The EUS identified local recurrence after 14 months in a 7 mm polypoid lesion removed with cold snare polypectomy (G1 R1); the lesion was treated with cap-assisted EMR. For all the other lesions, the follow-up was negative. Conclusions: When rNETs are improperly removed without prior staging, caution must be exercised. The data from our cohort suggest that even if inappropriate resection had happened, patients may be safely managed with early EUS evaluation.
Conspiracy of Silence in Head and Neck Cancer Diagnosis: A Scoping Review
Authors: Saldivia-Siracusa Cristina , Dos Santos Erison Santana , González-Arriagada Wilfredo Alejandro , Prado-Ribeiro Ana Carolina , Brandão Thaís Bianca , Owosho Adepitan , Lopes Marcio Ajudarte , Epstein Joel B. , Santos-Silva Alan Roger
Published: July 2024

Cancer disclosure represents a complex healthcare dynamic. Physicians or caregivers may be prompted to withhold diagnosis information from patients. This study aims to comprehensively map and synthesize available evidence about diagnosis nondisclosure regarding head and neck cancer (HNC) patients. Following the Joanna Briggs Institute guidelines, a scoping review was conducted across major databases without period restriction, yielding 9238 publications. After screening and selection, a descriptive synthesis was conducted. Sixteen studies were included, primarily conducted in academic settings (75%) from Europe and Asia, with a total population of 662 patients predominantly diagnosed with brain, oral, pharyngeal, or laryngeal tumors. Remarkably, 22.51% of patients were unaware of their diagnosis. Although physicians were the main source of diagnostic information (35%), they reported to often use vague terms to convey malignancy. Additionally, 13.29% of patients were aware of their diagnosis from sources other than doctors or caregivers. Caregivers (55%) supported diagnosis concealment, and physicians tended to respect family wishes. A high diagnosis-to-death interval, education, and age significantly influenced diagnosis disclosure. HNC patients expressed a desire for personalized open communication. Multiple factors influenced the decision on diagnosis disclosure. Current evidence on this topic varies significantly, and there is limited research on the consequences of nondisclosure. These findings reflect the underestimation of the patients’ outlook in the diagnosis process and highlight the need for further research, aiming to establish open communication and patient autonomy during the oncological journey.
NodeFlow: Towards End-to-End Flexible Probabilistic Regression on Tabular Data
Authors: Wielopolski Patryk , Furman Oleksii , Zięba Maciej
Published: July 2024

We introduce NodeFlow, a flexible framework for probabilistic regression on tabular data that combines Neural Oblivious Decision Ensembles (NODEs) and Conditional Continuous Normalizing Flows (CNFs). It offers improved modeling capabilities for arbitrary probabilistic distributions, addressing the limitations of traditional parametric approaches. In NodeFlow, the NODE captures complex relationships in tabular data through a tree-like structure, while the conditional CNF utilizes the NODE’s output space as a conditioning factor. The training process of NodeFlow employs standard gradient-based learning, facilitating the end-to-end optimization of the NODEs and CNF-based density estimation. This approach ensures outstanding performance, ease of implementation, and scalability, making NodeFlow an appealing choice for practitioners and researchers. Comprehensive assessments on benchmark datasets underscore NodeFlow’s efficacy, revealing its achievement of state-of-the-art outcomes in multivariate probabilistic regression setup and its strong performance in univariate regression tasks. Furthermore, ablation studies are conducted to justify the design choices of NodeFlow. In conclusion, NodeFlow’s end-to-end training process and strong performance make it a compelling solution for practitioners and researchers. Additionally, it opens new avenues for research and application in the field of probabilistic regression on tabular data.
Temporal Direction, Intuitionism and Physics
Authors: Dolev Yuval
Published: July 2024

In a recent paper, Nicolas Gisin suggests that by conducting physics with intuitionistic rather than classical mathematics, rich temporality—that is, passage and tense, and specifically the future’s openness—can be incorporated into physics. Physics based on classical mathematics is tenseless and deterministic, and that, so he holds, renders it incongruent with experience. According to Gisin, physics ought to represent the indeterminate nature of reality, and he proposes that intuitionistic mathematics is the key to succeeding in doing so. While I share his insistence on the reality of passage and tense and on the future being real and open, I argue that the amendment he offers does not work. I show that, its attunement to time notwithstanding, intuitionistic mathematics is as tenseless as classical mathematics and that physics is bound to remain tenseless regardless of the math it employs. There is much to learn about tensed time, but the task belongs to phenomenology and not to physics.