bluuebunny/crossref_metadata_2025 huggingface dataset:
Global decrease in brain sodium concentration after mild traumatic brain injury
Authors: Gerhalter Teresa , Chen Anna M , Dehkharghani Seena , Peralta Rosemary , Adlparvar Fatemeh , Babb James S , Bushnik Tamara , Silver Jonathan M , Im Brian S , Wall Stephen P , Brown Ryan , Baete Steven H , Kirov Ivan I , Madelin Guillaume
Published: March 2021

The pathological cascade of tissue damage in mild traumatic brain injury is set forth by a perturbation in ionic homeostasis. However, whether this class of injury can be detected in vivo and serve as a surrogate marker of clinical outcome is unknown. We employ sodium MRI to test the hypotheses that regional and global total sodium concentrations: (i) are higher in patients than in controls and (ii) correlate with clinical presentation and neuropsychological function. Given the novelty of sodium imaging in traumatic brain injury, effect sizes from (i), and correlation types and strength from (ii), were compared to those obtained using standard diffusion imaging metrics. Twenty-seven patients (20 female, age 35.9 ± 12.2 years) within 2 months after injury and 19 controls were scanned with proton and sodium MRI at 3 Tesla. Total sodium concentration, fractional anisotropy and apparent diffusion coefficient were obtained with voxel averaging across 12 grey and white matter regions. Linear regression was used to obtain global grey and white matter total sodium concentrations. Patient outcome was assessed with global functioning, symptom profiles and neuropsychological function assessments. In the regional analysis, there were no statistically significant differences between patients and controls in apparent diffusion coefficient, while differences in sodium concentration and fractional anisotropy were found only in single regions. However, for each of the 12 regions, sodium concentration effect sizes were uni-directional, due to lower mean sodium concentration in patients compared to controls. Consequently, linear regression analysis found statistically significant lower global grey and white matter sodium concentrations in patients compared to controls. The strongest correlation with outcome was between global grey matter sodium concentration and the composite z-score from the neuropsychological testing. In conclusion, both sodium concentration and diffusion showed poor utility in differentiating patients from controls, and weak correlations with clinical presentation, when using a region-based approach. In contrast, sodium linear regression, capitalizing on partial volume correction and high sensitivity to global changes, revealed high effect sizes and associations with patient outcome. This suggests that well-recognized sodium imbalances in traumatic brain injury are (i) detectable non-invasively; (ii) non-focal; (iii) occur even when the antecedent injury is clinically mild. Finally, in contrast to our principle hypothesis, patients’ sodium concentrations were lower than controls, indicating that the biological effect of traumatic brain injury on the sodium homeostasis may differ from that in other neurological disorders.

Note: This figure has been annotated.
Predictors of sinus rhythm 6 weeks after cardioversion of atrial fibrillation: a pre-planned post hoc analysis of the X-VeRT trial
Authors: Cappato Riccardo , Ezekowitz Michael D , Hohnloser Stefan H , Meng Isabelle Ling , Wosnitza Melanie , Camm , and Arthur John ,   the X-VeRT Steering Committee and Investigators
Published: March 2021

Aims

Using a pre-planned post hoc analysis of patients included in X-VeRT, we evaluated predictors of sinus rhythm at 6 weeks after planned cardioversion.

Methods and results

Receiver operating characteristic curves and logistic regression models were used to evaluate continuous and categorical variables as predictors of sinus rhythm 6 at weeks from cardioversion (end of study). The primary analysis was performed in successfully cardioverted patients with an evaluable electrocardiogram at end of study. A second analysis evaluated additional patients who spontaneously restored sinus rhythm before planned cardioversion. Of the 1504 patients with atrial fibrillation of >48 h or of unknown duration who were randomly assigned to either rivaroxaban or vitamin K antagonist, 1039 (64.6 ± 10.3 years, 73.4% male) underwent planned cardioversion and were included in this study. Patients receiving early cardioversion (i.e. between 1 and 5 days from hospitalization) had a 67% higher probability to have sinus rhythm at end of study than those who received delayed cardioversion (i.e. between 21 and 56 days from hospitalization) [odds ratio (OR) 1.67, confidence interval (CI) 1.27–2.18; P < 0.0001]. In a multivariate analysis of 17 baseline variables, patients with a CHADS2 score of 0 were 33% less likely to be in sinus rhythm than those with a CHADS2 score ≥2 (OR 0.66, CI 0.47–0.94; P = 0.0225). In the secondary analysis, spontaneous restoration of sinus rhythm was also found to predict sinus rhythm at end of study (OR 8.62, CI 1.54–48.16; P = 0.0142).

Conclusion

In X-VeRT, early cardioversion and high CHADS2 scores predicted sinus rhythm at 6 weeks from cardioversion.
A meta-analysis of clinical risk factors for stroke in anticoagulant-naïve patients with atrial fibrillation
Authors: Noubiap Jean Jacques , Feteh Vitalis Fambombi , Middeldorp Melissa E , Fitzgerald John L , Thomas Gijo , Kleinig Timothy , Lau Dennis H , Sanders Prashanthan
Published: March 2021

Aims

The aim of this study is to summarize data from prospective cohort studies on clinical predictors of stroke and systemic embolism in anticoagulant-naïve atrial fibrillation (AF) patients.

Methods and results

EMBASE, MEDLINE, Global Index Medicus, and Web of Science were searched to identify all studies published by 28 November 2019. Forty-seven studies reporting data from 1 756 984 participants in 15 countries were included. The pooled incidence of stroke in anticoagulant-naïve AF patients was 23.8 per 1000 person-years (95% CI 19.7–28.2). Older age was associated with incident stroke or systemic embolism, with a pooled hazard ratio (HR) of 2.14 (95% CI 1.85–2.47), 2.83 (95% CI 2.27–3.51), and 6.87 (95% CI 6.33–7.44) for age 65–75, ≥75, and ≥85 years, respectively. Other predictors of stroke or systemic embolism included history of stroke or TIA (HR 2.84, 95% CI 2.19–3.67), hypertension (HR 1.60, 95% CI 1.37–1.86), diabetes (HR 1.28, 95% CI 1.20–1.37), heart failure (HR 1.25, 95% CI 1.11–1.40), peripheral artery disease (pooled HR 1.35, 95% CI 1.04–1.75), vascular disease (pooled HR 1.21, 95% CI 1.06–1.39), and prior myocardial infarction (pooled HR 1.08, 95% CI 1.03–1.14). Female sex was a predictor of thromboembolism in studies outside Asia (HR 1.35, 95% CI 1.15–1.59), but not in those done in Asia (HR 0.95, 95% CI 0.81–1.10).

Conclusion

This study confirms age and prior stroke as the strongest predictors of stroke or systemic embolism in anticoagulant-naive AF patients. Other predictors include hypertension, diabetes, heart failure, and vascular disease. Female sex seems not to be universally associated with stroke or systemic embolism.
The relationship between duration and quality of sleep and upper respiratory tract infections: a systematic review
Authors: Robinson Charlotte H , Albury Charlotte , McCartney David , Fletcher Benjamin , Roberts Nia , Jury Imogen , Lee Joseph
Published: March 2021

Background

Upper respiratory tract infections (URTIs) are common, mostly self-limiting, but result in inappropriate antibiotic prescriptions. Poor sleep is cited as a factor predisposing to URTIs, but the evidence is unclear.

Objective

To systematically review whether sleep duration and quality influence the frequency and duration of URTIs.

Methods

Three databases and bibliographies of included papers were searched for studies assessing associations between sleep duration or quality and URTIs. We performed dual title and abstract selection, discussed full-text exclusion decisions and completed 50% of data extraction in duplicate. The Newcastle–Ottawa Quality Assessment Scale assessed study quality and we estimated odds ratios (ORs) using random effects meta-analysis.

Results

Searches identified 5146 papers. Eleven met inclusion criteria, with nine included in meta-analyses: four good, two fair and five poor for risk of bias. Compared to study defined ‘normal’ sleep duration, shorter sleep was associated with increased URTIs (OR: 1.30, 95% confidence interval [CI]: 1.19–1.42, I2: 11%, P < 0.001) and longer sleep was not significantly associated (OR: 1.11 95% CI: 0.99–1.23, I2: 0%, P = 0.070). Sensitivity analyses using a 7- to 9-hour baseline found that sleeping shorter than 7–9 hours was associated with increased URTIs (OR: 1.31, 95% CI: 1.22–1.41, I2: 0%, P < 0.001). Sleeping longer than 7–9 hours was non-significantly associated with increased URTIs (OR: 1.15, 95% CI: 1.00–1.33, I2: 0%, P = 0.050, respectively). We were unable to pool sleep quality studies. No studies reported on sleep duration and URTI severity or duration.

Conclusions

Reduced sleep, particularly shorter than 7–9 hours, is associated with increased URTIs. Strategies improving sleep should be explored to prevent URTIs.
Magmatic channelization by reactive and shear-driven instabilities at mid-ocean ridges: a combined analysis
Authors: Rees Jones D W , Zhang H , Katz R F
Published: March 2021

It is generally accepted that melt extraction from the mantle at mid-ocean ridges (MORs) is concentrated in narrow regions of elevated melt fraction called channels. Two feedback mechanisms have been proposed to explain why these channels grow by linear instability: shear flow of the partially molten mantle and reactive flow of the ascending magma. These two mechanisms have been studied extensively, in isolation from each other, through theory and laboratory experiments as well as field and geophysical observations. Here, we develop a consistent theory that accounts for both proposed mechanisms and allows us to weigh their relative contributions. We show that interaction of the two feedback mechanisms is insignificant and that the total linear growth rate of channels is well-approximated by summing their independent growth rates. Furthermore, we explain how their competition is governed by the orientation of channels with respect to gravity and mantle shear. By itself, analysis of the reaction-infiltration instability predicts the formation of tube-shaped channels. We show that with the addition of even a small amount of extension in the horizontal, the combined instability favours tabular channels, consistent with the observed morphology of dunite bodies in ophiolites. We apply the new theory to MORs by calculating the accumulated growth and rotation of channels along streamlines of the solid flow. We show that reactive flow is the dominant instability mechanism deep beneath the ridge axis, where the most unstable orientation of high-porosity channels is subvertical. Channels are then rotated by the solid flow away from the vertical. The contribution of the shear-driven instability is confined to the margins of the melting region. Within the limitations of our study, the shear-driven feedback does not appear to be responsible for significant melt focusing or for the shallowly dipping seismic anisotropy that has been obtained by seismic inversions.
Male Aggregation in Dwarf Tyrant-Manakins and What It Tells Us about the Origin of Leks
Authors: Foster Mercedes S
Published: March 2021

Synopsis

Despite considerable research on lek-breeding birds, many aspects of the evolution of the lek social system, including the origin of male aggregation, remain unresolved. Originally, clusters may have formed passively as a by-product of independent but concurrent responses by males to some external stimulus (e.g., a concentration of display sites, prominent food source, or a travel corridor commonly used by females) that drew them at a particular time to a site where they might increase their probabilities of encountering females. In contrast, male aggregation may have been active, with a male purposely seeking to associate with another male (or males) because proximity to that male allowed him to enhance his own reproductive success by improving his ability to attract females (i.e., learning from his associate) or to intercept females attracted to that male. To identify factors important in the formation of male aggregations, I studied these alternatives in the Dwarf Tyrant-Manakin (Tyranneutes stolzmanni), a species in which some breeding males occupy solitary courts where they attempt to attract females for reproduction, whereas other males occupy courts clustered into leks, where they interact to attract females. I compared habitat characteristics and resource availability at courts of grouped and solitary males as well as certain traits of the males in an attempt to distinguish between passive or active lek formation in this species. Little evidence suggests that Dwarf Tyrant-Manakins are passively clustered as a result of common attraction to or use of a limited or unevenly distributed resource. Several observations suggest the contrary. Evidence for the active aggregation of males is more promising, suggesting that males may associate with other males on the basis of their vocal behavior. The issue is confounded, however, by the observation that male call behavior appears to change with a change in social status. A definitive answer for T. stolzmanni will require additional analyses of vocal behavior as well as of the characteristics of the vocalizations themselves. Finally, the behavior and social organization of this species may reflect characteristics of the ancestral manakin line that gave rise to both the Tyrant and Core clades of modern manakins.
Right-wing populism, the reasonable, and the limits of ideal theory: A reply to Gila Stopler
Authors: Prieto Rudolphy Marcela
Published: March 2021

This article replies to Gila Stopler’s critique of John Rawls’s Political Liberalism. It argues that there are two strands in Stopler’s arguments. The first is Stopler’s critique of Political Liberalism for its accommodation of “right-wing populism.” This article argues that “right-wing populism” is not a “reasonable comprehensive view” under Rawls’s theory. Thus, Political Liberalism does not accommodate this view; it excludes it from the possibility of a reasonable overlapping consensus. The second strand in Stopler’s article can be interpreted as an invitation to think about the value of idealization in political theory. More concretely, this article argues that Stopler’s claims can be read as suggesting that political liberalism’s flaw is not that it tolerates illiberal views, but that it tells us little about how to achieve and maintain an overlapping consensus about justice in the kind of societies we actually inhabit. This article briefly argues that this critique deserves attention, especially given the circumstances of today’s societies, where extreme views are not uncommon and the effects of climate change threaten the very possibility of justice.
The bind of tolerance and a call to feminist thought: A reply to Gila Stopler
Authors: Michelman Frank
Published: March 2021

There are no spaces or spheres of the personal or the private that are not also fraught with political potential and consequence. That insistent lesson from feminist thought is these days instanced, truly writes Gila Stopler, by the bafflements faced by liberal democracies confronting severe threat from illiberal ideas and incitements gathering steam under shelter of liberal basic-liberties guarantees. My questions here are whether the problem’s root in liberalism runs deeper than any ideology of a “private sphere,” and whether it is aggravated by a turn in John Rawls’s defense of liberal principles from a “comprehensive” to a “political” justificatory strategy.
Unexpected Cytomegalovirus (CMV) Replication Kinetics in CMV Donor-Seropositive, Recipient-Seronegative Liver Transplant Recipients Receiving Preemptive Antiviral Therapy
Authors: Singh Nina , Winston Drew J , Razonable Raymund R , Marshall Lyon G , Silveira Fernanda P , Wagener Marilyn M , Limaye Ajit P
Published: March 2021

Background

Detailed cytomegalovirus (CMV) kinetics in donor CMV-seropositive, recipient CMV-seronegative (D+/R–) transplant recipients receiving preemptive therapy (PET) have not been fully defined.

Methods

The study population consisted of the PET arm of a randomized CMV prevention trial in D+/R– liver transplant recipients. CMV DNA polymerase chain reaction (PCR) assays were performed weekly for 100 days using a sensitive assay. Viral load and clinical parameters were compared for patients with or without high-level increase (defined as higher than the group median log10 increase in viral load from baseline after PET initiation).

Results

Among 79 patients, 93.6% (74/79) developed an increase from baseline viral loads of median 120 IU/mL to 3350 IU/mL; 25.7% (19/74) of the patients had peak levels >10 000 IU/mL. None of the patients with rise in viral load underwent testing for CMV resistance, and viremia resolved with PET with valganciclovir. Patients with high-level increase in viral load had a significantly lower rate of recurrent viremia than those without such increase (16/40 [40%] vs 28/39 [71.8%], respectively; P = .004).

Conclusions

A majority of D+/R– recipients had a marked increase in viral load after initiation of PET before resolution of viremia. This phenomenon is associated with lower rates of subsequent recurrent viremia and does not necessarily imply antiviral resistance.
Using Innovation to Address Adolescent and Young Adult Health Disparities in Pelvic Inflammatory Disease: Design of the Technology Enhanced Community Health Precision Nursing (TECH-PN) Trial
Authors: Trent Maria , Perin Jamie , Rowell Julia , Shah Maunank , Anders Jennifer , Matson Pamela , Brotman Rebecca M , Ravel Jacques , Sharps Phyllis , Rothman Richard , Yusuf Hasiya E , Gaydos Charlotte A
Published: March 2021

New approaches to pelvic inflammatory disease (PID) care among adolescents and young adults (AYAs) that optimize self-care and personalize treatment are warranted to address age and racial-ethnic PID-related health disparities. Here we describe the 13-month preliminary feasibility and acceptability outcomes of recruitment, retention, and intervention delivery for Technology Enhanced Community Health Precision Nursing (TECH-PN) randomized controlled trial. Urban AYAs 13–25 years assigned female sex at birth with acute mild-moderate PID provided baseline and follow-up interview data and vaginal specimens for sexually transmitted infection (STI), cytokine, and microbiota assessment. All participants received medications and text-messaging support. Participants were block randomized to either control or intervention. Control participants received 1 community nursing visit with self-management for interim care per national guidelines. Intervention participants received unlimited precision care services driven by interim STI and macrolide resistance testing results by an advanced practice provider. In the first 13 months, 75.2% patients were eligible, and 76.1% of eligible patients enrolled. Of the participants, 94% completed the intervention and 96%, 91%, and 89%, respectively, completed their 14-, 30-, and 90-day visits. Baseline laboratory results revealed infection rates that were highest for Mycoplasma genitalium (45%) followed by Chlamydia trachomatis (31%). Preliminary enrollment, STI, intervention delivery, and retention data demonstrate the feasibility and acceptability of the TECH-PN intervention and support rationale for precision care for PID among urban AYAs.

ClinicalTrials.gov Identifier. NCT03828994.
Multi-Copy Gene Family Evolution on the Avian W Chromosome
Authors: Rogers Thea F , Pizzari Tommaso , Wright Alison E
Published: March 2021

The sex chromosomes often follow unusual evolutionary trajectories. In particular, the sex-limited chromosomes frequently exhibit a small but unusual gene content in numerous species, where many genes have undergone massive gene amplification. The reasons for this remain elusive with a number of recent studies implicating meiotic drive, sperm competition, genetic drift, and gene conversion in the expansion of gene families. However, our understanding is primarily based on Y chromosome studies as few studies have systematically tested for copy number variation on W chromosomes. Here, we conduct a comprehensive investigation into the abundance, variability, and evolution of ampliconic genes on the avian W. First, we quantified gene copy number and variability across the duck W chromosome. We find a limited number of gene families as well as conservation in W-linked gene copy number across duck breeds, indicating that gene amplification may not be such a general feature of sex chromosome evolution as Y studies would initially suggest. Next, we investigated the evolution of HINTW, a prominent ampliconic gene family hypothesized to play a role in female reproduction and oogenesis. In particular, we investigated the factors driving the expansion of HINTW using contrasts between modern chicken and duck breeds selected for different female-specific selection regimes and their wild ancestors. Although we find the potential for selection related to fecundity in explaining small-scale gene amplification of HINTW in the chicken, purifying selection seems to be the dominant mode of evolution in the duck. Together, this challenges the assumption that HINTW is key for female fecundity across the avian phylogeny.
Lupeol induces autophagy and apoptosis with reduced cancer stem-like properties in retinoblastoma via phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin inhibition
Authors: Che Songtian , Wu Shuai , Yu Peng
Published: March 2021

Objectives

To evaluate the anticancer effects of lupeol in retinoblastoma cells.

Methods

WERI-Rb-1 and Y-79 cell lines were used to evaluate the anticancer effect of lupeol. After lupeol treatment, the viability, proliferation, apoptosis, cancer stem-like properties, autophagy and in vivo tumour xenograft formation were detected.

Key findings

In this study, lupeol decreased cell viability in both WERI-Rb-1 and Y-79 cell lines. Lupeol could also inhibit proliferation and induce apoptosis of RB cells, with increased Bax level and decreased Ki67, survivin and Bcl-2 levels. Furthermore, lupeol could suppress the spheroid formation and stem-like properties of RB cells. Moreover, LC3 II/LC3 I ratio and the levels of Beclin1 and ATG7 were increased after lupeol treatment, indicating that lupeol could induce autophagy in RB cells. Next, the inhibitory effect of lupeol on the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway was observed. In tumour-bearing mice, lupeol suppressed tumour growth, and this might relate to its role in cell apoptosis, autophagy and stem-like properties.

Conclusions

Lupeol suppressed proliferation and cancer stem-like properties, and promoted autophagy and apoptosis of RB cells by restraining the PI3K/AKT/mTOR pathway.
Stereotactic body radiotherapy for kidney cancer: a 10-year experience from a single institute
Authors: Yamamoto Takaya , Kawasaki Yoshihide , Umezawa Rei , Kadoya Noriyuki , Matsushita Haruo , Takeda Kazuya , Ishikawa Yojiro , Takahashi Noriyoshi , Suzuki Yu , Takeda Ken , Kawabata Kousei , Ito Akihiro , Jingu Keiichi
Published: March 2021

The purpose of this retrospective study was to investigate survival outcomes and irradiated tumor control (local control [LC]) and locoregional control (LRC) after stereotactic body radiotherapy (SBRT) for T1 or recurrent T1 (rT1) kidney cancer. Twenty-nine nonconsecutive patients with 30 tumors were included. SBRT doses of 70 Gy, 60 Gy or 50 Gy in 10 fractions were prescribed with a linear accelerator using daily image guidance. The Kaplan–Meier method was used to estimate time-to-event outcomes, and the log-rank test was used to compare survival curves between groups divided by each possible factor. The median follow-up periods for all patients and survivors were 57 months and 69.6 months, respectively. The five-year LC rate, LRC rate, progression-free survival (PFS) rate, disease-specific survival (DSS) rate and overall survival (OS) rate were 94%, 88%, 50%, 96% and 68%, respectively. No significant factor was related to OS and PFS. Three of 24 non-hemodialysis (HD) patients had new-onset-HD because of the progression of underlying kidney disease. Grade 3 or higher toxicities from SBRT did not occur. In conclusion, SBRT for kidney cancer provided a high rate of LC, LRC and DSS with minimal toxicities, but patient selection and indication for SBRT should be done carefully considering the relatively low OS rate.
NGTS 15b, 16b, 17b, and 18b: four hot Jupiters from the Next-Generation Transit Survey
Authors: Tilbrook Rosanna H , Burleigh Matthew R , Costes Jean C , Gill Samuel , Nielsen Louise D , Vines José I , Queloz Didier , Hodgkin Simon T , Worters Hannah L , Goad Michael R , Acton Jack S , Henderson Beth A , Armstrong David J , Anderson David R , Bayliss Daniel , Bouchy François , Briegal Joshua T , Bryant Edward M , Casewell Sarah L , Chaushev Alexander , Cooke Benjamin F , Eigmüller Philipp , Gillen Edward , Günther Maximilian N , Hogan Aleisha , Jenkins James S , Lendl Monika , McCormac James , Moyano Maximiliano , Raynard Liam , Smith Alexis M S , Udry Stéphane , Watson Christopher A , West Richard G , Wheatley Peter J , Breytenbach Hannes , Sefako Ramotholo R , Thomas Jessymol K , Alves Douglas R
Published: March 2021

We report the discovery of four new hot Jupiters with the Next-Generation Transit Survey (NGTS). NGTS-15b, NGTS-16b, NGTS-17b, and NGTS-18b are short-period (P < 5 d) planets orbiting G-type main-sequence stars, with radii and masses between 1.10 and 1.30RJ and 0.41 and 0.76MJ, respectively. By considering the host star luminosities and the planets’ small orbital separations (0.039–0.052 au), we find that all four hot Jupiters are highly irradiated and therefore occupy a region of parameter space in which planetary inflation mechanisms become effective. Comparison with statistical studies and a consideration of the planets’ high incident fluxes reveal that NGTS-16b, NGTS-17b, and NGTS-18b are indeed likely inflated, although some disparities arise upon analysis with current Bayesian inflationary models. However, the underlying relationships that govern radius inflation remain poorly understood. We postulate that the inclusion of additional hyperparameters to describe latent factors such as heavy element fraction, as well as the addition of an updated catalogue of hot Jupiters, would refine inflationary models, thus furthering our understanding of the physical processes that give rise to inflated planets.
A cool and inflated progenitor candidate for the Type Ib supernova 2019yvr at 2.6 yr before explosion
Authors: Kilpatrick Charles D , Drout Maria R , Auchettl Katie , Dimitriadis Georgios , Foley Ryan J , Jones David O , DeMarchi Lindsay , French K Decker , Gall Christa , Hjorth Jens , Jacobson-Galán Wynn V , Margutti Raffaella , Piro Anthony L , Ramirez-Ruiz Enrico , Rest Armin , Rojas-Bravo César
Published: March 2021

We present Hubble Space Telescope imaging of a pre-explosion counterpart to SN 2019yvr obtained 2.6 yr before its explosion as a type Ib supernova (SN Ib). Aligning to a post-explosion Gemini-S/GSAOI image, we demonstrate that there is a single source consistent with being the SN 2019yvr progenitor system, the second SN Ib progenitor candidate after iPTF13bvn. We also analysed pre-explosion Spitzer/Infrared Array Camera (IRAC) imaging, but we do not detect any counterparts at the SN location. SN 2019yvr was highly reddened, and comparing its spectra and photometry to those of other, less extinguished SNe Ib we derive $E(B-V)=0.51\substack{+0.27\\ -0.16}$ mag for SN 2019yvr. Correcting photometry of the pre-explosion source for dust reddening, we determine that this source is consistent with a log (L/L⊙) = 5.3 ± 0.2 and $T_{\mathrm{eff}} = 6800\substack{+400\\ -200}$ K star. This relatively cool photospheric temperature implies a radius of 320$\substack{+30\\ -50}~\mathrm{ R}_{\odot}$, much larger than expectations for SN Ib progenitor stars with trace amounts of hydrogen but in agreement with previously identified SN IIb progenitor systems. The photometry of the system is also consistent with binary star models that undergo common envelope evolution, leading to a primary star hydrogen envelope mass that is mostly depleted but still seemingly in conflict with the SN Ib classification of SN 2019yvr. SN 2019yvr had signatures of strong circumstellar interaction in late-time (>150 d) spectra and imaging, and so we consider eruptive mass-loss and common envelope evolution scenarios that explain the SN Ib spectroscopic class, pre-explosion counterpart, and dense circumstellar material. We also hypothesize that the apparent inflation could be caused by a quasi-photosphere formed in an extended, low-density envelope, or circumstellar matter around the primary star.
BAT AGN Spectroscopic Survey XXVII: scattered X-Ray radiation in obscured active galactic nuclei
Authors: Gupta K K , Ricci C , Tortosa A , Ueda Y , Kawamuro T , Koss M , Trakhtenbrot B , Oh K , Bauer F E , Ricci F , Privon G C , Zappacosta L , Stern D , Kakkad D , Piconcelli E , Veilleux S , Mushotzky R , Caglar T , Ichikawa K , Elagali A , Powell M C , Urry C M , Harrison F
Published: March 2021

Accreting supermassive black holes (SMBHs), also known as active galactic nuclei (AGN), are generally surrounded by large amounts of gas and dust. This surrounding material reprocesses the primary X-ray emission produced close to the SMBH and gives rise to several components in the broadband X-ray spectra of AGN, including a power-law possibly associated with Thomson-scattered radiation. In this work, we study the properties of this scattered component for a sample of 386 hard-X-ray-selected, nearby ($z\sim0.03$) obscured AGN from the 70-month Swift/BAT catalogue. We investigate how the fraction of Thomson-scattered radiation correlates with different physical properties of AGN, such as line-of-sight column density, X-ray luminosity, black hole mass, and Eddington ratio. We find a significant negative correlation between the scattering fraction and the column density. Based on a large number of spectral simulations, we exclude the possibility that this anticorrelation is due to degeneracies between the parameters. The negative correlation also persists when considering different ranges of luminosity, black hole mass, and Eddington ratio. We discuss how this correlation might be either due to the angle dependence of the Thomson cross-section or to more obscured sources having a higher covering factor of the torus. We also find a positive correlation between the scattering fraction and the ratio of [O iii] λ5007 to X-ray luminosity. This result is consistent with previous studies and suggests that the Thomson-scattered component is associated with the narrow-line region.
The structural evolution of isolated galaxies at low redshift in the IllustrisTNG simulation
Authors: Walters Dan , Woo Joanna , Ellison Sara L , Hani Maan H
Published: March 2021

We study the structural evolution of isolated star-forming (SF) galaxies in the IllustrisTNG100-1 hydrodynamical simulation, with a focus on investigating the growth of the central core density within 2 kpc (Σ*,2 kpc) in relation to total stellar mass (M*) at z < 0.5. First, we show that several observational trends in the Σ*,2 kpc–M* plane are qualitatively reproduced in IllustrisTNG, including the distributions of active galactic nuclei (AGN), SF galaxies, quiescent galaxies, and radial profiles of stellar age, specific star formation rate (sSFR), and metallicity. We find that galaxies with dense cores evolve parallel to the Σ*,2 kpc–M* relation, while galaxies with diffuse cores evolve along shallower trajectories. We investigate possible drivers of rapid growth in Σ*,2 kpc compared to M*. Both the current sSFR gradient and the black hole (BH) accretion rate are indicators of past core growth, but are not predictors of future core growth. Major mergers (although rare in our sample; ∼10 per cent) cause steeper core growth, except for high-mass ($M_{\rm *}\gtrsim 10^{10} \, {\rm M}_{\odot }$) mergers, which are mostly dry. Disc instabilities, as measured by the fraction of mass with Toomre Q < 2, are not predictive of rapid core growth. Instead, rapid core growth results in more stable discs. The cumulative BH feedback history sets the maximum rate of core growth, preventing rapid growth in high-mass galaxies ($\gtrsim 10^{9.5} \, {\rm M}_{\odot }$). For massive galaxies, the total specific angular momentum of accreting gas is the most important predictor of future core growth. Our results suggest that the angular momentum of accreting gas controls the slope, width, and zero-point evolution of the Σ*,2 kpc–M* relation.
A model of active transcription hubs that unifies the roles of active promoters and enhancers
Authors: Zhu Iris , Song Wei , Ovcharenko Ivan , Landsman David
Published: March 2021

An essential questions of gene regulation is how large number of enhancers and promoters organize into gene regulatory loops. Using transcription-factor binding enrichment as an indicator of enhancer strength, we identified a portion of H3K27ac peaks as potentially strong enhancers and found a universal pattern of promoter and enhancer distribution: At actively transcribed regions of length of ∼200–300 kb, the numbers of active promoters and enhancers are inversely related. Enhancer clusters are associated with isolated active promoters, regardless of the gene's cell-type specificity. As the number of nearby active promoters increases, the number of enhancers decreases. At regions where multiple active genes are closely located, there are few distant enhancers. With Hi-C analysis, we demonstrate that the interactions among the regulatory elements (active promoters and enhancers) occur predominantly in clusters and multiway among linearly close elements and the distance between adjacent elements shows a preference of ∼30 kb. We propose a simple rule of spatial organization of active promoters and enhancers: Gene transcriptions and regulations mainly occur at local active transcription hubs contributed dynamically by multiple elements from linearly close enhancers and/or active promoters. The hub model can be represented with a flower-shaped structure and implies an enhancer-like role of active promoters.
Pan-cancer analysis of non-coding recurrent mutations and their possible involvement in cancer pathogenesis
Authors: Kikutake Chie , Yoshihara Minako , Suyama Mikita
Published: March 2021

Cancer-related mutations have been mainly identified in protein-coding regions. Recent studies have demonstrated that mutations in non-coding regions of the genome could also be a risk factor for cancer. However, the non-coding regions comprise 98% of the total length of the human genome and contain a huge number of mutations, making it difficult to interpret their impacts on pathogenesis of cancer. To comprehensively identify cancer-related non-coding mutations, we focused on recurrent mutations in non-coding regions using somatic mutation data from COSMIC and whole-genome sequencing data from The Cancer Genome Atlas (TCGA). We identified 21 574 recurrent mutations in non-coding regions that were shared by at least two different samples from both COSMIC and TCGA databases. Among them, 580 candidate cancer-related non-coding recurrent mutations were identified based on epigenomic and chromatin structure datasets. One of such mutation was located in RREB1 binding site that is thought to interact with TEAD1 promoter. Our results suggest that mutations may disrupt the binding of RREB1 to the candidate enhancer region and increase TEAD1 expression levels. Our findings demonstrate that non-coding recurrent mutations and coding mutations may contribute to the pathogenesis of cancer.
Validating E-Cigarette Dependence Scales Based on Dynamic Patterns of Vaping Behaviors
Authors: Buu Anne , Cai Zhanrui , Li Runze , Wong Su-Wei , Lin Hsien-Chang , Su Wei-Chung , Jorenby Douglas E , Piper Megan E
Published: March 2021

Introduction

Existing e-cigarette dependence scales are mainly validated based on retrospective overall consumption or perception. Further, given that the majority of adult e-cigarette users also use combustible cigarettes, it is important to determine whether e-cigarette dependence scales capture the product-specific dependence. This study fills in the current knowledge gaps by validating e-cigarette dependence scales using novel indices of dynamic patterns of e-cigarette use behaviors and examining the association between dynamic patterns of smoking and e-cigarette dependence among dual users.

Methods

Secondary analysis was conducted on the 2-week ecological momentary assessment data from 116 dual users. The Smoothly Clipped Absolute Deviation penalty (SCAD) was adopted to select important indices for dynamic patterns of consumption or craving and estimate their associations with e-cigarette dependence scales.

Results

The fitted linear regression models support the hypothesis that higher e-cigarette dependence is associated with higher levels of e-cigarette consumption and craving as well as lower instability of e-cigarette consumption. Controlling for dynamic patterns of vaping, dual users with lower e-cigarette dependence tend to report higher day-to-day dramatic changes in combustible cigarette consumption but not higher average levels of smoking.

Conclusions

We found that more stable use patterns are related to higher levels of dependence, which has been demonstrated in combustible cigarettes and we have now illustrated in e-cigarettes. Furthermore, the e-cigarette dependence scales may capture the product-specific average consumption but not product-specific instability of consumption.

Implications

This study provides empirical support for three e-cigarette dependence measures: PS-ECDI, e-FTCD, and e-WISDM, based on dynamic patterns of e-cigarette consumption and craving revealed by EMA data that have great ecological validity. This is the first study that introduces novel indices of dynamic patterns and demonstrates their potential applications in vaping research.
Prejudice
Authors: Begby Endre
Published: March 2021

Prejudiced beliefs may certainly seem like defective beliefs. But in what sense defective? No doubt, many of them will be false. Some will also be harmful. But many philosophers further argue that prejudiced belief is defective also in the sense that it could only arise from distinctive kinds of epistemic irrationality: we could acquire or retain our prejudiced beliefs only by culpably violating our epistemic responsibilities. Moreover, it is assumed that we are morally responsible for the harms that our prejudiced beliefs cause only because, in forming these beliefs in the first place, we are violating our epistemic responsibilities. This book argues that these common convictions are false and misguided. It shows in detail that there can be plenty of epistemically justified pathways to prejudiced belief. Moreover, it argues that it is a mistake to lean on the concept of epistemic responsibility to give content to ethical responsibilities. In particular, this would unreasonably burden victims of prejudice with having to show that their victimizers were in a position to know better. Accordingly, this book develops an account of moral responsibility for harm which does not depend on finding grounds for epistemic blame. In support of this view, the book offers a number of examples and case studies at individual, collective, and institutional levels of decision making. Additionally, it develops a systematic platform for “non-ideal epistemology” which would apply also to a wide range of other socio-epistemic phenomena of current concern, such as fake news, conspiracy theories, science scepticism, and more.
Officer Receptivity to Body-Worn Cameras
Authors: Bartholomew Brad , Bennett Richard R , Baxter Sandra K , Champagne Holly
Published: March 2021

The growing public outrage in the USA and elsewhere over police-related deaths of people of colour has intensified the debate over body-worn cameras (BWCs). Unlike most research on officers’ experience-based acceptance of BWCs, this study examines receptivity: initial attitudes before learning whether or not they would be assigned a camera. Knowledge of receptivity is important for informing an agency’s roll-out of BWCs. It increases the likelihood of obtaining buy-in from its officers and helping to achieve positive outcomes from the technology. The analysis, based on the Technology Acceptance Model, focused on officer attitudes predicting receptivity while controlling for their demographic characteristics. Beliefs in the evidentiary value of BWCs, their role in increasing officer safety, and likely civilizing effects on community members increased receptivity significantly; fear of supervisory sanctions played no role. This article concludes with a discussion of policy implications.
Severe infections in patients with ANCA-associated vasculitis treated with rituximab
Authors: Segelmark Leo , Flores-Suárez Luis , Mohammad Aladdin
Published: March 2021

Objectives

Rituximab (RTX) is an anti-CD20 antibody that selectively depletes B cells and has emerged as a therapy for ANCA-associated vasculitis (AAV) during the past decade. This study sought to quantify and determine potential risk factors for severe infections in AAV patients treated with RTX at rheumatology clinics in Mexico City, Mexico and Lund, Sweden.

Methods

The study consisted of a retrospective case-record review (2005–15) with standardized data collection related to the occurrence of severe infection in 46 patients with AAV in Mexico City (n = 20) and Lund (n = 26) treated with RTX during their disease course. Median duration of follow-up from first RTX dose to death or end of study was 26 months.

Results

Eleven (24%) patients suffered a total of 18 severe infections (infection rate of 11.5/100 patient-years). Thirteen of the 18 infections (72%) occurred within the first year of treatment. Risk factors for severe infection were older age at RTX initiation and absence of ENT involvement at diagnosis. In multivariate analyses, age at RTX infusion was the only independent factor predicting severe infection. Four patients (9%) died during follow-up, all as a result of infection.

Conclusion

Severe infections are common following RTX treatment, and mortality due to infection is a major concern. Most severe infections occur within the first year of RTX treatment. The negative correlation of ENT involvement with severe infection might reflect granulomatosis with polyangiitis phenotype heterogeneity. Older age at time of RTX treatment independently predicts severe infections.
PERSONAL DOSIMETRY USING MONTE-CARLO SIMULATIONS FOR OCCUPATIONAL DOSE MONITORING IN INTERVENTIONAL RADIOLOGY: THE RESULTS OF A PROOF OF CONCEPT IN A CLINICAL SETTING
Authors: Almén A , Andersson M , O’Connor U , Abdelrahman M , Camp A , García V , Duch M A , Ginjaume M , Vanhavere F
Published: March 2021

Exposure levels to staff in interventional radiology (IR) may be significant and appropriate assessment of radiation doses is needed. Issues regarding measurements using physical dosemeters in the clinical environment still exist. The objective of this work was to explore the prerequisites for assessing staff radiation dose, based on simulations only.

Personal dose equivalent, Hp(10), was assessed using simulations based on Monte Carlo methods. The position of the operator was defined using a 3D motion tracking system. X-ray system exposure parameters were extracted from the x-ray equipment. The methodology was investigated and the simulations compared to measurements during IR procedures.

The results indicate that the differences between simulated and measured staff radiation doses, in terms of the personal dose equivalent quantity Hp(10), are in the order of 30–70 %. The results are promising but some issues remain to be solved, e.g. an automated tracking of movable parts such as the ceiling-mounted protection shield.
The Impact of I-Corps on Accelerating Venture Discontinuation in a Southeastern US University
Authors: Youtie Jan , Kwon , Seokbeom , Woo Seokkyun
Published: March 2021

This study contributes to the literature on accelerators which focuses on private sector accelerators by providing an analysis of an accelerator in the public sphere that works with early-stage, science-driven applications, the National Science Foundation’s Innovation-Corps (I-Corps) program. The methodology is based on a comparison of the ability of the services delivered through the I-Corps program to teams at the Georgia Institute of Technology (Georgia Tech) to speed their venture project discontinuation decisions over and above those of researchers receiving baseline commercialization services only. We find modest evidence that the I-Corps program helped Georgia Tech I-Corps teams make faster decisions to discontinue venture projects. The total savings of quicker I-Corps project discontinuation are estimated at more than $3.6 million over the 8-year observation period.
Multiyear Evaluation of Fungicide Efficacy and Application Timing for Control of Southern Rust in Hybrid Corn in Arkansas
Authors: Faske Travis R. , Emerson Michael
Published: March 2021

The efficacy and timing of eight foliar fungicides to manage southern rust of corn (caused by Puccinia polysora Underwood) was investigated over 4 years in three field experiments. Each experiment consisted of one-, two-, or three-fungicide application timings at tassel, milk, or dent growth stages with quinone outside inhibitor (QoI), demethylation inhibitor (DMI), or QoI + DMI fungicides. Each year trace amounts of southern rust were observed in the field at tassel, except in 2018, when rust was not observed until physiological maturity. Southern rust severity on ear leaf and two leaves above the ear leaf was approximately 50, 35, 75, and 0% at dent in 2015, 2016, 2017, and 2018, respectively. Applications that contained a QoI or QoI + DMI fungicide provided greater southern rust control than DMI fungicides, with little variation within fungicide classes. Applications of QoI or QoI + DMI fungicides applied at tassel provided greater disease control (52.5%) than those applied at milk (5.8%) or dent (1.4%), and greater yield protection (40.4%) than those applied at milk (23.7%) or dent (2.6%) when final rust development was severe (>40%). When rust development increased later in the season, after milk growth stage, a trend of better disease control was observed with fungicides applied at milk (57.8%) compared with tassel (35.2%), but grain yield protection was similar, with an average yield protection of 7.4%. There was no yield benefit with fungicides applied in the absence of disease or at the dent growth stage. Southern rust was most effectively managed with QoI or QoI + DMI fungicides applied at tassel when southern rust was present and environmental conditions favored rust development.