bluuebunny/crossref_metadata_2025 huggingface dataset:
Benzyldimethyldodecyl Ammonium Chloride-Doped Denture-Based Resin: Impact on Strength, Surface Properties, Antifungal Activities, and In Silico Molecular Docking Analysis
Authors: Aldulaijan Sarah , Alruwili Raghad , Almulaify Rawan , Alhassan Fatimah A. , Al-Dulaijan Yousif A. , Alshahrani Faris A. , Mokeem Lamia , Gad Mohammed M. , Melo Mary Anne S. , Balhaddad Abdulrahman A.
Published: October 2024

Candida albicans (C. albicans) adhering to denture-based resins (DBRs) is a known cause of denture stomatitis. A new approach to prevent denture stomatitis is to include antimicrobial substances within DBRs. Here, we examined the mechanical performance and antifungal properties of DBRs containing benzyldimethyldodecyl ammonium chloride (C12BDMA-Cl) as an antimicrobial compound. C12BDMA-Cl is a quaternary ammonium compound, and its antifungal properties have never been investigated when combined with dental acrylic resin. Therefore, we modified a commercially available heat-polymerized acrylic DBR to contain 3 and 5 wt.% of C12BDMA-Cl. Unmodified DBR was used as a control group. Specimens were prepared using the conventional heat processing method. The specimen’s flexural strength, elastic modulus, microhardness, and surface roughness were evaluated. C. albicans biofilm was grown on the specimens and assessed via colony-forming units (CFUs) and scanning electron microscopy (SEM). In silico molecular docking was applied to predict the potential C12BDMA-Cl inhibition activity as an antifungal drug. The 3% C12BDMA-Cl DBR demonstrated antifungal activities without a deterioration effect on the mechanical performance. SEM images indicated fewer colonies in DBR containing C12BDMA-Cl, which can be a potential approach to managing denture stomatitis. In conclusion, C12BDMA-Cl is a promising antifungal agent for preventing and treating denture stomatitis.
Mechanical and Microstructural Characterization of Class 800 Complex Phase Steel before and after the Laser Welding Process
Authors: Neto Antonio dos Reis de Faria , Dias Erica Ximenes , Fukugauchi Cristina Sayuri , Martins Marcelo Sampaio , Pereira Marcelo dos Santos
Published: October 2024

Complex phase steels, known for their high levels of conformability, energy absorption, and deformation capacity, are among the more advanced high-strength steels. The objective of this study was to compare the mechanical properties of CPW 800-class complex phase steels, with and without laser welding. The analysis involved determining tensile strength, yield strength, elongation, and area reduction through tensile tests, in scenarios both with and without laser welding. Additionally, the number of cycles was assessed via fatigue tests, and absorbed energy was measured using impact tests. The non-parametric Kruskal–Wallis test, at a 5% significance level, revealed that tensile strength, yield strength, area reduction, and absorbed energy were statistically similar regardless of laser welding. However, elongation and the number of cycles showed significant differences. The fractured surface from axial fatigue tests exhibited ductile characteristics, with the additional presence of dimples or alveoli.
Challenges in Maritime Cybersecurity Training and Compliance
Authors: Chupkemi Divine C. , Mersinas Konstantinos
Published: October 2024

The implementation of cybersecurity standards and directives in the maritime sector plays a crucial role in protecting critical maritime infrastructures from cyber threats. The level of protection depends heavily on humans. However, the effectiveness of cybersecurity training and compliance programmes, an essential component of these standards, is often hindered by challenges related to the sector’s environment, including the established technologies, practices, and norms. This paper aims to identify these challenges through a literature review and set the basis for more effective human risk minimization, responses, and training. We identify 17 challenges and validate them with an online survey (N = 205) capturing real-world perspectives from maritime-related stakeholders. Our findings contribute to enhancing the effectiveness of maritime cybersecurity training and compliance programmes, ultimately strengthening the maritime cybersecurity posture.
An Analysis of the Flexural Stiffness and Horizontal Bearing Capacity of CFRP Composite Pipe Piles in Marine Environments
Authors: Zhang Wei , Shao Wei , Nie Yinghui
Published: October 2024

Carbon-fiber-reinforced polymer (CFRP) is a composite material consisting of a resin matrix reinforced with carbon fibers. This study focuses on CFRP composite pipe piles as the subject of investigation, exploring the impact of substituting steel bars with CFRP bars on the bending performance of pipe piles through rigorous three-point bending tests. The attenuation of flexural stiffness in CFRP pipe piles under a chloride salt environment was anticipated. The lateral bearing capacity of CFRP pipe piles was calculated by introducing a stiffness degradation coefficient for the piles and utilizing the finite difference method. The findings of the analysis suggest that as the CFRP reinforcement replacement rate increases, the initial bending stiffness of the composite pipe pile experiences a corresponding decrease. After serving for 28.15 years, the steel reinforcement within the pipe pile commences rusting, resulting in a nonlinear decline in the bending stiffness of the composite pipe pile. As the service time of pipe piles increases, a higher replacement rate of CFRP reinforcement results in a slower attenuation of pile stiffness. Consequently, both the horizontal displacement at the top of the pile and the bending moment along the body of the composite pipe pile gradually increase over time. During the same service period, the higher the rate of CFRP reinforcement, the less noticeable the attenuation in the horizontal bearing capacity of the pile shaft.
Therapeutic Drug Monitoring of Elexacaftor, Tezacaftor, and Ivacaftor in Adult People with Cystic Fibrosis
Authors: Naehrig Susanne , Shad Christina , Breuling Magdalena , Goetschke Melanie , Habler Katharina , Sieber Sarah , Kastenberger Johanna , Kunzelmann Alexandra Katharina , Sommerburg Olaf , Liebchen Uwe , Behr Juergen , Vogeser Michael , Paal Michael
Published: October 2024

Background/Objectives: Elexacaftor, tezacaftor, and ivacaftor (ETI) have significantly improved lung function in people with cystic fibrosis (pwCF). Despite exceptional improvements in most cases, treatment-related inter-subject variability and drug–drug interactions that complicate modulator therapy have been reported. Methods: This retrospective analysis presents data on the serum concentration of ETI in our pwCF with full or reduced dosage from August 2021 to December 2023 via routine therapeutic drug monitoring (TDM). The data were compared with the maximum drug concentrations (Cmax) from the pharmaceutical company’s summary of product characteristics. Results: A total of 786 blood samples from 155 pwCF (41% female, 59% male) were analyzed. The examinations were divided into four groups: full dose within the given tmax (38.5% of all measurements), full dose outside the tmax (29%), reduced dose within the tmax (19.2%), and reduced dose outside the tmax (13.2%). In pwCF receiving the full dose and blood taken within the tmax, 45.3% of serum concentrations of elexacaftor, 51.1% of serum concentrations of ivacaftor, and 8.9% of serum concentrations of tezacaftor were found to be above the Cmax, respectively. For those on reduced doses within the tmax, 24.5% had a serum concentration of elexacaftor, 23.2% had a serum concentration of ivacaftor, and 2.5% had a serum concentration of tezacaftor above the Cmax, respectively. Conclusions: Many pwCF under ETI therapy have Cmax values for elexacaftor and ivacaftor above the recommended range, even on reduced doses or before the tmax was reached. This highlights the value of a TDM program. Further pharmacokinetic studies are necessary.
Research into the Influence Mechanisms of Visual-Comfort and Landscape Indicators of Urban Green Spaces
Authors: Meng Yumeng , Shi Jiaxuan , Lyu Mei , Sun Dong , Fukuda Hiroatsu
Published: October 2024

Urban green spaces play a crucial role in providing social services and enhancing residents’ mental health. It is essential for sustainable urban planning to explore the relationship between urban green spaces and human perceptions, particularly their visual comfort. However, most current research has analyzed green spaces using two-dimensional indicators (remote sensing), which often overlook human visual perceptions. This study combined two-dimensional and three-dimensional methods to evaluate urban green spaces. Additionally, the study employed machine learning to quantify residents’ visual comfort in green-space environments and explored the relationship between green spaces and human visual perceptions. The results indicated that Kitakyushu exhibited a moderate FCV and an extremely low Green View Index (GVI). Yahatanishi-ku was characterized as having the highest visual comfort. Tobata-ku demonstrated the lowest visual comfort. Natural, GVI, openness, enclosure, vegetation diversity, landscape diversity, and NDBI were positively correlated with visual comfort. FCV and ENVI were negatively correlated with visual comfort. Vegetation diversity had the most impact on improving visual comfort. By integrating remote sensing and street-view data, this study introduces a methodology to ensure a more holistic assessment of green spaces. Urban planners could use it to better identify areas with insufficient green space or areas that require improvement in terms of green-space quality. Meanwhile, it could be helpful in providing valuable input for formulating more effective green-space policies and improving overall urban environmental quality. The study provides a scientific foundation for urban planners to improve the planning and construction of healthy and sustainable cities.
Learning from Two Early Brownfield Redevelopment Projects in Italy: Soil Desealing, Cooling Effects, and Implementation of Nature-Based Solutions Through Traditional Planning Tools
Authors: Falco Enzo , Garda Emanuele , Zardo Linda , Cortinovis Chiara
Published: October 2024

Consideration of the future fate of brownfields in urban environments has driven a complex ‘season’ of decisions, planning, and implementation that has seen the emergence of different approaches and actions for their reuse. Among the various experiences of brownfield redevelopment, some projects have also promoted the partial renaturalisation of areas through soil desealing and demolition of existing buildings. These greening initiatives have provided new public facilities, e.g., parks and green areas, helping to improve the conditions of urban environments both from ecological and social perspectives. This article adopts ex ante and ex post methods to analyse two Italian case studies of brownfield regeneration involving desealing interventions and investigates two key aspects: (i) the planning process and tools that were put in place to implement the projects and (ii) the impacts for human wellbeing that were produced in terms of cooling effects. The analyses conducted show the real effectiveness of renaturation interventions especially related to reforestation measures in terms of temperature reduction. The examination of the two case studies also revealed the importance and potential success of traditional planning and implementation tools in promoting interventions that can now be considered innovative in terms of their actual contribution to current urban challenges. The results therefore allow us to emphasize the fundamental importance of the philosophy and basic principles of a transformation process, even guided by traditional planning tools, for the improvement of the environmental conditions of an urban context and the successful implementation of nature-based solutions.
Fractional Flow Reserve Implications for Clinical Decision Making in Coronary Artery Disease
Authors: Grib Andrei , Abras Marcel , Surev Artiom , Grib Livi
Published: October 2024

Fractional flow reserve (FFR) is regarded as the gold standard for assessing the functional significance of coronary artery lesions. However, its utilization in clinical practice remains limited. This study aims to determine whether FFR results can influence treatment decisions for coronary artery disease compared to visual assessments of angiographic images. We conducted a retrospective study involving 63 patients diagnosed with either chronic coronary syndrome (n = 39, 61.9%) or acute coronary syndrome (n = 24, 38.1%) who underwent an FFR assessment. Three experienced interventional cardiologists (>300 PCI procedures/year) reevaluated 105 ambiguous coronary lesions in these patients, blinded to the FFR results. The objective was to assess lesion significance and determine the treatment strategy based on a visual angiographic evaluation. The three operators reached concordant agreement (≥two operators) to perform PCI in 60 (57.1%) of the evaluated lesions based on the angiographic assessment. Of these, nine lesions (15%) were deemed functionally non-significant by FFR (FFR > 0.80). Conversely, they agreed to defer PCI in 45 (42.9%) lesions, but 4 lesions (8.9%) were found to be functionally significant (FFR ≤ 0.80) and required a re-evaluation for PCI. Visual-guided decision making by interventional cardiologists shows variability and does not always align with the functional significance of coronary lesions as determined by FFR. Incorporating FFR into routine decision making could enhance treatment accuracy and patient outcomes.
Pathophysiology of Congenital High Production of IgE and Its Consequences: A Narrative Review Uncovering a Neglected Setting of Disorders
Authors: Galletta Francesca , Gambadauro Antonella , Foti Randazzese Simone , Passanisi Stefano , Sinatra Vito , Caminiti Lucia , Zirilli Giuseppina , Manti Sara
Published: October 2024

Elevated serum IgE levels serve as a critical marker for uncovering hidden immunological disorders, particularly inborn errors of immunity (IEIs), which are often misdiagnosed as common allergic conditions. IgE, while typically associated with allergic diseases, plays a significant role in immune defense, especially against parasitic infections. However, extremely high levels of IgE can indicate more severe conditions, such as Hyper-IgE syndromes (HIES) and disorders with similar features, including Omenn syndrome, Wiskott-Aldrich syndrome, and IPEX syndrome. Novel insights into the genetic mutations responsible for these conditions highlight their impact on immune regulation and the resulting clinical features, including recurrent infections, eczema, and elevated IgE. This narrative review uniquely integrates recent advances in the genetic understanding of IEIs and discusses how these findings impact both diagnosis and treatment. Additionally, emerging therapeutic strategies, such as hematopoietic stem cell transplantation (HSCT) and gene therapies, are explored, underscoring the potential for personalized treatment approaches. Emphasizing the need for precise diagnosis and tailored interventions aims to enhance patient outcomes and improve the quality of care for those with elevated IgE levels and associated immunological disorders.
Hydatid Cysts of the Psoas Muscle: Insights from the Past Five Years
Authors: Ciobotaru Octavian Catalin , Duca Oana-Monica , Ciobotaru Oana Roxana , Stamate Elena , Piraianu Alin Ionut , Dumitrascu Adrian George , Constantin Georgiana Bianca , Matei Madalina Nicoleta , Voinescu Doina Carina , Luchian Stefan-Alexandru
Published: October 2024

Echinococcosis represents a major public health issue and continues to be endemic in various regions around the world. Hydatid cysts are commonly located in the liver (primary site), followed by the lungs (secondary site). However, they are also found in less typical organs such as the spleen, kidneys, peritoneum, retroperitoneum, pancreas, gallbladder, and various other organs, as well as in striate muscles. Hydatid cysts involving the psoas muscle are rare, and in the past five years, only a few articles have addressed this condition due to its low incidence. Symptoms can be quite vague, and serological testing might return negative, making imaging studies crucial for an accurate diagnosis. Treatment options involve surgery alongside antiparasitic agents. Despite having a low mortality rate, the recurrence of hydatid disease remains high. This paper aims to provide new clinical data through our case presentation, while also offering a review of the cases of hydatid cysts involving the psoas muscle that have been published over the past five years.
On Properties of Karamata Slowly Varying Functions with Remainder and Their Applications
Authors: Imomov Azam A. , Tukhtaev Erkin E. , Sztrik János
Published: October 2024

In this paper, we study the asymptotic properties of slowly varying functions of one real variable in the sense of Karamata. We establish analogs of fundamental theorems on uniform convergence and integral representation for slowly varying functions with a remainder depending on the types of remainder. We also prove several important theorems on the asymptotic representation of integrals of Karamata functions. Under certain conditions, we observe a “narrowing” of classes of slowly varying functions concerning the types of remainder. At the end of the paper, we discuss the possibilities of the application of slowly varying functions in the theory of stochastic branching systems. In particular, under the condition of the finiteness of the moment of the type Exlnx for the particle transformation intensity, it is established that the property of slow variation with a remainder is implicitly present in the asymptotic structure of a non-critical Markov branching random system.
Ocular Manifestation of Granulomatosis with Polyangiitis Presenting as Serous Retinal Detachment: A Case Report
Authors: Lee Junwoo , Choi Jaehwan , Yu Seung-Young , Kim Kiyoung
Published: October 2024

Background: Ocular involvement is relatively common in granulomatosis with polyangiitis (GPA); however, choroidal involvement is rare. We present a case of serous retinal detachment resulting from choroidal involvement in GPA. Case presentation: A 55-year-old male presented to our clinic with bilateral eye redness and pain. Ocular examination revealed bilateral conjunctival injection, and dilation of the episcleral and scleral vessels. Slit-lamp examination revealed anterior chamber cells. Optical coherence tomography (OCT) confirmed serous retinal detachment (SRD) in the left eye. The patient had recently been diagnosed with GPA following a lung biopsy and had received immunosuppressive therapy, including systemic steroids, cyclosporine, mycophenolate mofetil, and rituximab. Five weeks after treatment, the clinical symptoms of the patient, including SRD, improved with alleviation of systemic symptoms. However, tapering systemic steroids and immunosuppressants and discontinuing rituximab led to disease reactivation. OCT demonstrated a recurrence of subretinal fluid, which had previously resolved, and slit-lamp examination showed mild bilateral engorged scleral vessels. Conclusions: Choroidal involvement can present as SRD and may indicate disease activity in patients with GPA.
Cannabis Use during Pregnancy: An Update
Authors: Gerede Angeliki , Stavros Sofoklis , Chatzakis Christos , Vavoulidis Eleftherios , Papasozomenou Panagiota , Domali Ekaterini , Nikolettos Konstantinos , Oikonomou Efthymios , Potiris Anastasios , Tsikouras Panagiotis , Nikolettos Nikolaos
Published: October 2024

The use of cannabis during pregnancy has emerged as a mounting cause for concern due to its potential adverse consequences on both the mother and her offspring. This review will focus on the dangers associated with prenatal exposure to cannabis, particularly those related to neurodevelopment. It will also discuss the features of maternal and placental functioning that are likely to have long-term effects on the offspring’s development. The most pertinent and up-to-date materials can be found through a literature search. The literature emphasizes the substantial hazards associated with prenatal exposure to cannabis. These include impairments in cognitive function and difficulties in behavior in this particular instance. Structural and functional alterations in the brain can be noticed in offspring. The use of cannabis has been associated with an increased likelihood of experiencing pregnancy-related complications, such as giving birth prematurely and having a baby with a low birth weight. Additionally, it has been connected to potential negative effects on mental and emotional well-being. Studies have shown that when a pregnant woman is exposed to cannabis, it can negatively impact the functioning of the placenta and the growth of the fetus. This might potentially contribute to the development of placental insufficiency and restricted growth in the womb. Longitudinal studies reveal that children who were exposed to cannabis in the womb experience additional long-term developmental challenges, such as decreased cognitive abilities, reduced academic performance, and behavioral issues. In order to address the problem of cannabis usage during pregnancy, it is essential to adopt a comprehensive and coordinated strategy. This method should integrate and synchronize public health policy, education, and research initiatives. By implementing these targeted strategies, it is possible to mitigate potential health and welfare concerns for both present and future generations.
Avascular Necrosis of the Talus: Diagnosis, Treatment, and Modern Reconstructive Options
Authors: Kubisa Michał Jan , Kubisa Marta Gabriela , Pałka Karol , Sobczyk Jakub , Bubieńczyk Filip , Łęgosz Paweł
Published: October 2024

Talar avascular necrosis (AVN) is a devastating condition that frequently follows type III and IV talar neck fractures. As 60% of the talus is covered by hyaline cartilage, its vascular supply is limited and prone to trauma, which may eventually lead to AVN development. Early detection of AVN (Hawkins sign, MRI) is crucial, as it may prevent the development of the irreversible stages III and IV of AVN. Alertness is advised regarding non-obvious conditions that may cause this complication (sub chondroplasty, systemic lupus erythematosus, diabetes mellitus). Although, in stages I–II, AVN may be treated with non-surgical procedures (ESWT therapy, non-weight bearing) or joint-sparing techniques (core drilling, bone marrow aspirate injections), stages III–IV require more advanced procedures, such as joint-sacrificing procedures (hindfoot arthrodesis/ankle arthrodesis), or replacement surgery, including total talar replacement (TTR) or combined total ankle replacement (TAR). The advancement of 3D-printing technology and increased access to implant manufacturing are contributing to a rise in the production rates of third-generation total talar prostheses. As a result, there is a growing frequency of alloplasty procedures and combined total ankle replacement (TAR) surgeries. By performing TTR as opposed to deses, the operator avoids (i) delayed union, (ii) a shortening of the limb, (iii) a lack of mobility, and (iv) the stiffening of adjacent joints, which are the main disadvantages of joint-sacrificing procedures. Simultaneously, TTR and combined TAR offer (i) a brief period of weight-bearing restriction, (ii) quick pain relief, and (iii) preservation of the length of the limb. Here, we summarize the most up-to-date knowledge regarding AVN diagnosis and treatment, with a special focus on the role of TTR.
The Effect of CKD-495, Eupacidin, and Their Marker Compounds on Altered Permeability in a Postoperative Ileus Animal Model
Authors: Kim Min-Jae , Hussain Zahid , Lee Young Ju , Park Hyojin
Published: October 2024

Background and Objectives: Postoperative ileus (POI) is a delay in gastrointestinal transit following surgery that leads to various complications. There is limited understanding of its effective treatment options. CKD-495 and eupacidin are natural products licensed for treating mucosal lesions in acute and chronic gastritis; however, little is known about their effects on intestinal permeability. This study evaluated the effects of CKD-495, eupacidin, and its components (eupatilin and cinnamic acid) on intestinal permeability in an animal model of POI. Materials and Methods: Guinea pigs underwent surgical procedures and were randomly assigned to different treatment groups. Drugs were administered orally prior to surgery. Intestinal permeability, leukocyte count, and the expression of calprotectin and tight junction proteins were measured in the harvested ileum tissue. Results: The intestinal permeability and leukocyte count were higher in the POI group than in the control group. The pre-administration of CKD-495, cinnamic acid, eupacidin, and eupatilin effectively prevented these changes in the POI model. No significant differences were observed in the expression of tight junction proteins. Conclusions: CKD-495, cinnamic acid, eupacidin, and eupatilin exerted protective effects against increased intestinal permeability and inflammation in an animal model of POI. These natural products have potential as therapeutic options for the treatment of POI.
Clinical and Drug Resistance Characteristics of Providencia Infections
Authors: Malviya Meenal , Kale-Pradhan Pramodini , Coyle Meredith , Giuliano Christopher , Johnson Leonard B.
Published: October 2024

Background: Providencia is a G ram-negative bacillus that most frequently colonizes the urinary tract and is often resistant to many antimicrobials. This study aimed to evaluate the resistance patterns of Providencia spp. and clinical outcomes due to the paucity of data. Methods: A multi-center, descriptive, retrospective chart review of adult patients with Providencia spp. infections was conducted from 1 January 2020 to 31 May 2022. The primary outcome was to describe the drug resistance patterns of Providencia spp. isolates. This study’s secondary outcome was to evaluate the clinical outcomes of patients with Providencia spp. infections. Results: Of the 312 patients screened, 244 were excluded primarily for polymicrobial infections. The mean age was 70 years, and 39 (56.5%) were males. Of the 68 included cases, 46 (67.6%) were P. stuartii, 20 (29.4%) were P. rettgeri, and 2 (2.9%) were P. alcalifaciens. The most common infections were bacteremia 38 (55.8%), followed by 27 (39.7%) urinary tract infections and 3 (4.4%) wound infections. In this study, 45 patients (65.2%) had urinary catheters. The primary antibiotics used for treatment consisted of ceftriaxone (25 (36.2%)), cefepime (20 (29%)), and meropenem (10 (14.5%)). Only 5 of 68 (7.2%) cases were multidrug- resistant and required meropenem. In total, 19 patients (27.1%) died during their admission, but none were related to Providencia infections. A total of 10 of the 68 patients (14.5%) were readmitted within 30 days for reasons unrelated to the progression or recurrence of Providencia infections. Conclusions:Providencia bacteremia is predominantly seen in elderly patients. Third- generation cephalosporins remain an appropriate choice of antibiotics for Providencia spp. Providencia stuartii was the only species with multidrug resistance.
Mechanisms of Reservoir Space Preservation in Ultra-Deep Shales: Insights from the Ordovician–Silurian Wufeng–Longmaxi Formation, Eastern Sichuan Basin
Authors: Wang Pengwan , He Xiaolong , Chen Ya’na , Xu Chuan , Cao Quanbin , Yang Kai , Zhang Bing
Published: October 2024

This study aims to explore the reservoir characteristics and formation mechanisms of ultra-deep shale gas in the Ordovician–Silurian Wufeng–Longmaxi Formation in the Sichuan Basin in order to provide theoretical support and practical guidance for the exploration and development of ultra-deep shale gas. With recent breakthroughs in ultra-deep shale gas exploration, understanding its organic matter development, mineral composition, and reservoir space characteristics has become particularly important. The background of this research lies in the significant potential of ultra-deep shale gas, which remains inadequately understood, necessitating an in-depth analysis of its pore structure and reservoir quality. Through a systematic study of the ultra-deep shale in well FS1 of Sichuan Basin, that the following was found: (i) The ultra-deep shale in the Wufeng–Longmaxi Formation is mainly composed of quartz and clay minerals, exhibiting high total organic carbon (TOC) and high porosity characteristics, indicating it is in an overmature thermal evolution stage. (ii) Organic pores and microcracks in the ultra-deep shale are more developed compared to middle-shallow and deep shale, forming a complex pore structure that is conducive to gas storage. (iii) In the diagenesis process, the dissolution and recrystallization of the biogenic skeleton promote the cementation between autogenetic quartz particles, forming a rigid skeleton that effectively inhibits the impact of mechanical compaction. (iv) The overpressure environment created by the hydrocarbon generation process, along with gas production from hydrocarbon cracking, can effectively offset the mechanical compaction of overburden pressure on micropores, and this overpressure environment also promotes the further development of microfractures, which is beneficial for the development and preservation of ultra-deep shale pores. In summary, this study not only reveals the reservoir characteristics and formation mechanisms of ultra-deep shale but also provides essential references for the exploration and development of ultra-deep shale gas in the Sichuan Basin and similar regions, emphasizing the ongoing significance of research in this field.
Virtual Tasting in the Metaverse: Technological Advances and Consumer Behavior Impacts
Authors: Moustapha Farouk Adéwalé , Ertz Myriam , Ouerghemmi Chourouk
Published: October 2024

Product tasting is a key element in improving customer satisfaction in the commercial environment. This study looks at the notion of traditional tasting and its effect on customer behavior and explores emerging tasting techniques, shedding light on the contribution of digital tasting. Indeed, the advent of the metaverse has made it possible to offer new virtual tasting experiences. However, this experience does not yet involve a sense of taste. Our manuscript highlights the potential of tasting in the metaverse through a descriptive study of various concrete cases of international brands that have included it in their marketing strategies. In light of the results, practical and theoretical recommendations are provided for professionals interested in leveraging virtual tools to improve consumer satisfaction.
NariTan: Enhancing Second Language Vocabulary Learning Through Non-Human Avatar Embodiment in Immersive Virtual Reality
Authors: Fukushima Shogo , Sakamoto Keigo , Nakamura Yugo
Published: October 2024

With the rise of head-mounted displays (HMDs), immersive virtual reality (IVR) for second-language learning is gaining attention. However, current methods fail to fully exploit IVR’s potential owing to the use of abstract avatars and limited human perspectives in learning experiences. This study investigated IVR’s novel potential by using non-human avatars to understand complex concepts. We developed a system for learning English vocabulary through the actions of non-human avatars, offering a unique learning perspective. This paper presents an IVR vocabulary learning environment with a dragon avatar and compares word retention rates (immediate and one-week memory tests), subjective workload, and emotional changes with traditional methods. We also examined the vocabulary ranges that are teachable using this system by varying the number of avatars. The results showed that the proposed method significantly reduced forgotten English words after one week compared to traditional methods, indicating its effectiveness in the long term.
Exploring the Potential of Bimetallic PtPd/C Cathode Catalysts to Enhance the Performance of PEM Fuel Cells
Authors: Guterman Vladimir , Alekseenko Anastasia , Belenov Sergey , Menshikov Vladislav , Moguchikh Elizaveta , Novomlinskaya Irina , Paperzh Kirill , Pankov Ilya
Published: October 2024

Bimetallic platinum-containing catalysts are deemed promising for electrolyzers and proton-exchange membrane fuel cells (PEMFCs). A significant number of laboratory studies and commercial offers are related to PtNi/C and PtCo/C electrocatalysts. The behavior of PtPd/C catalysts has been studied much less, although palladium itself is the metal closest to platinum in its properties. Using a series of characterization methods, this paper presents a comparative study of structural characteristics of the commercial PtPd/C catalysts containing 38% wt. of precious metals and the well-known HiSpec4000 Pt/C catalyst. The electrochemical behavior of the catalysts was studied both in a three-electrode electrochemical cell and in the membrane electrode assemblies (MEAs) of hydrogen–air PEMFCs. Both PtPd/C samples demonstrated higher values of the electrochemically active surface area, as well as greater specific and mass activity in the oxygen reduction reaction in comparison with conventional Pt/C, while not being inferior to the latter in durability. The MEA based on the best of the PtPd/C catalysts also exhibited higher performance in single tests and long-term durability testing. The results of this study conducted indicate the prospects of using bimetallic PtPd/C materials for cathode catalysts in PEMFCs.
The Influence of Prone Positioning on Energy and Protein Delivery in COVID-19 Patients Requiring ECMO Support
Authors: Hintersteininger Marlene , Haselwanter Patrick , Maleczek Mathias , Laxar Daniel , Hermann Martina , Hermann Alexander , Buchtele Nina , Staudinger Thomas , Zauner Christian , Schneeweiss-Gleixner Mathias
Published: October 2024

Background: Gastrointestinal dysfunction is a common complication of medical nutrition therapy in critically ill patients. Whether prone positioning leads to a deterioration in gastrointestinal function has not been fully clarified. Thus, we aimed to analyze the influence of prone positioning on the tolerance of medical nutrition therapy. Methods: We conducted a retrospective analysis of 102 SARS-CoV-2 infected patients with venovenous extracorporeal membrane oxygenation support (VV ECMO). Gastric residual volume (GRV) was used to assess the tolerance of enteral nutrition. Results: Nutritional data were collected for 2344 days. Undernutrition was observed in 40.8%, with a significantly higher incidence on days in prone position (48.4% versus 38.6%, p < 0.001). On days in supine position, significantly more calories were administered enterally than on days in prone position (p < 0.001). The mean GRV/24 h was 111.1 mL on days in supine position and 187.3 mL on days in prone position (p < 0.001). Prone positioning was associated with higher rates of GRV of ≥500 mL/24 h independent of age, disease severity at ECMO start, ECMO runtime and ICU length of stay (adjusted hazard ratio: 4.06; 95%CI: 3.0–5.5; p < 0.001). Conclusions: Prone position was associated with lower tolerance of enteral nutrition, as indicated by an increased GRV. As a result, reduced enteral nutritional support was administered.
Correction: Simionescu et al. The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy. Pharmaceutics 2021, 13, 988
Authors: Simionescu Natalia , Zonda Radu , Petrovici Anca Roxana , Georgescu Adriana
Published: October 2024

In the original publication [...]
Holographic Multi-Notch Filters Recorded with Simultaneous Double-Exposure Contact Mirror-Based Method
Authors: Zhuang Bing-Han , Hung Sheng-Chun , Chen Kun-Huang , Yeh Chien-Hung , Chen Jing-Heng
Published: October 2024

This study presents a novel simultaneous double-exposure contact mirror-based method for fabricating holographic multi-notch filters with dual operational central wavelengths. The proposed method leverages coupled wave theory, the geometric relationships of K-vectors, and a reflection-type recording setup, incorporating additional reflecting mirrors to guide the recording beams. To validate the approach, a holographic notch filter was fabricated using photopolymer recording materials, resulting in operational wavelengths of 531.13 nm and 633.01 nm. The measured diffraction efficiencies at these wavelengths were ηs = 52.35% and ηp = 52.45% for 531.13 nm, and ηs = 67.30% and ηp = 67.40% for 633.01 nm. The component’s performance was analyzed using s- and p-polarized spectral transmission intensities at various reconstruction angles, revealing polarization-independent characteristics under normal incidence and polarization-dependent behavior under oblique incidence. The study also explored the relationships between recording parameters, such as incident angle, wavelength, emulsion expansion, and dispersion. The findings demonstrate that the first operational central wavelength is primarily influenced by the recording wavelength, while the second is primarily determined by the incident angle, covering a range from visible light to near-infrared. This method offers significant potential for cost-effective, mass-produced filters in optoelectronic applications.
Erbium-Doped Tunable Fiber Laser Based on a Vernier Effect Filter
Authors: Liu Yuanzhen , Xu Hailong , Zhu Kexin , Yao Yicun , Suo Yuman , Zhang Liqiang
Published: October 2024

A novel vernier effect filter is designed utilizing two cascaded Mach–Zehnder interferometers (MZIs). Integrating the filter into an erbium-doped fiber laser (EDFL), the tunability of laser wavelength is achieved. Each MZI comprises two sequentially interconnected 3 dB optical couplers (OCs), where the incoming light is initially split into two arms at the first OC and subsequently recombined at the second OC. Interference occurs due to the optical path difference between these two beams. Notably, the two MZIs exhibit closely matched free spectral ranges (FSRs), leading to the formation of a broadened envelope in the superimposed spectrum. By delicately adjusting the optical path difference between the two arms of one MZI, a little drift of the interference spectrum is induced. This small amount of drift, in turn, triggers a significant movement of the envelope, giving rise to the so-called vernier effect. Integrating the vernier effect filter into an EDFL, the wavelength of the fiber laser can be tuned from 1542.56 nm to 1556.62 nm, with a tuning range of 14.06 nm. Furthermore, by employing a high-precision stepper motor, a remarkable tuning accuracy of 0.01 nm is attainable. The side mode suppression ratio of all wavelengths is above 55 dB. In comparison to reported tunable fiber lasers utilizing MZI filters, the proposed fiber laser in this study offers enhanced precision and a more user-friendly tuning process.
Imaging of Live Cells by Digital Holographic Microscopy
Authors: Mihaylova Emilia Mitkova
Published: October 2024

Imaging of microscopic objects is of fundamental importance, especially in life sciences. Recent fast progress in electronic detection and control, numerical computation, and digital image processing, has been crucial in advancing modern microscopy. Digital holography is a new field in three-dimensional imaging. Digital reconstruction of a hologram offers the remarkable capability to refocus at different depths inside a transparent or semi-transparent object. Thus, this technique is very suitable for biological cell studies in vivo and could have many biomedical and biological applications. A comprehensive review of the research carried out in the area of digital holographic microscopy (DHM) for live-cell imaging is presented. The novel microscopic technique is non-destructive and label-free and offers unmatched imaging capabilities for biological and bio-medical applications. It is also suitable for imaging and modelling of key metabolic processes in living cells, microbial communities or multicellular plant tissues. Live-cell imaging by DHM allows investigation of the dynamic processes underlying the function and morphology of cells. Future applications of DHM can include real-time cell monitoring in response to clinically relevant compounds. The effect of drugs on migration, proliferation, and apoptosis of abnormal cells is an emerging field of this novel microscopic technique.
The Influence of Different Factors on the Metabolism of Capsaicinoids in Pepper (Capsicum annuum L.)
Authors: Yang Yuanling , Gao Chengan , Ye Qingjing , Liu Chenxu , Wan Hongjian , Ruan Meiying , Zhou Guozhi , Wang Rongqing , Li Zhimiao , Diao Ming , Cheng Yuan
Published: October 2024

Pepper is a globally cultivated vegetable known for its distinct pungent flavor, which is derived from the presence of capsaicinoids, a class of unique secondary metabolites that accumulate specifically in pepper fruits. Since the accumulation of capsaicinoids is influenced by various factors, it is imperative to comprehend the metabolic regulatory mechanisms governing capsaicinoids production. This review offers a thorough examination of the factors that govern the metabolism of capsaicinoids in pepper fruit, with a specific focus on three primary facets: (1) the impact of genotype and developmental stage on capsaicinoids metabolism, (2) the influence of environmental factors on capsaicinoids metabolism, and (3) exogenous substances like methyl jasmonate, chlorophenoxyacetic acid, gibberellic acid, and salicylic acid regulate capsaicinoid metabolism. The findings of this study are expected to enhance comprehension of capsaicinoids metabolism and aid in the improvement of breeding and cultivation practices for high-quality pepper in the future.
Responses of the Allium cepa L. to Heavy Metals from Contaminated Soil
Authors: Opriș Ocsana , Lung Ildiko , Gméling Katalin , Stegarescu Adina , Buczkó Noémi , Culicov Otilia , Soran Maria-Loredana
Published: October 2024

Heavy metals can accumulate and migrate in soil environments and can negatively affect crops and consumers. Because an increased incidence of chronic diseases can be observed, food security has become a high-priority concern. In the present work, we evaluate the impact of heavy metals on bioactive compounds and elemental content from onions. Plants were grown in the absence and presence of various concentrations of heavy metal salts (Pb, Mn, Cu, Zn, Ni and Cd). The influence of heavy metal salts on onions was evaluated by analyzing the content of bioactive compounds, antioxidant capacity, and elemental content. The variation of assimilatory pigments, total polyphenols content, and antioxidant capacity increased or decreased depending on the heavy metal added to the soil as well as on the amount added. Regarding the amount of bioactive compounds, it increased between 6.79 and 34.39% or decreased between 4.68 and 62.42%. The content of ten elements in plants was reported, as well as elemental mutual correlation and correlation of element content with biologically active compounds and antioxidant capacity.
Early Flowering and Maturity Promote the Successful Adaptation and High Yield of Quinoa (Chenopodium quinoa Willd.) in Temperate Regions
Authors: Emrani Nazgol , Maldonado-Taipe Nathaly , Hasler Mario , Patiranage Dilan S. R. , Jung Christian
Published: October 2024

Quinoa (Chenopodium quinoa Willd.) can offer an alternative for staple food considering its tolerance to abiotic stresses and high seed quality. However, its cultivation in temperate regions has not been successful due to its photoperiod sensitivity and low seed yield. This study investigated the agronomical performance and quality traits of 48 accessions for cultivation in northern Europe. We conducted two-year field trials and phenotyped traits related to phenological development, plant architecture, yield components, seed quality, and disease resistance. The major determinants of seed yield in this study were days to flowering, days to maturity, thousand-kernel weight, and panicle density, while downy mildew susceptibility and stem lodging showed a negative correlation with seed yield. We developed a selection index to enable simultaneous selection based on different important agronomical traits. We evaluated the stability of different accessions over the two years of the experiment. Finally, we provided a list of 10 selected accessions that can be directly integrated and serve as new crossing parents in quinoa breeding programs for temperate regions.
The Impact of Short-Term Drought on the Photosynthetic Characteristics and Yield of Peanuts Grown in Saline Alkali Soil
Authors: He Kang , Xu Yang , Ding Hong , Guo Qing , Ci Dunwei , Zhang Jialei , Qin Feifei , Xu Manlin , Zhang Guanchu
Published: October 2024

Peanuts grown in saline alkali soil are also subjected to drought stress caused by water scarcity. Therefore, we used HY25 (peanut variety) as an experimental material to investigate the effects of drought on the height of peanut main stems, length of the first lateral branch, leaf area per plant, SPAD value, net photosynthetic rate, and accumulation and distribution of photosynthetic products in saline alkali soil. The results showed that the combined stress of short-term drought and salt significantly reduced the main stem height, first lateral branch length, single plant leaf area, SPAD value, net photosynthetic rate (Pn), intercellular carbon dioxide concentration (Ci), and dry matter accumulation of peanuts, including a decrease in single plant pod yield, 100-pod weight, 100-kernel weight, and peanut yield. And the impact of drought stress on peanut yield varies at different growth stages. For example, under drought stress alone, the sensitive period is the 40th day after planting (40D) > 60th day after planting (60D) > 30th day after planting (30D). Short-term drought has the greatest impact on peanut yield at 40D, while in contrast, resuming watering after drought at 30D results in a slight but not significant increase in peanut yield in comparison with the control. Under the combined stress of drought and salt, the sensitive period of peanuts was 40D > 30D > 60D, and the single pod weight of peanuts was significantly reduced by 15.26% to 57.60% from the flowering stage to the pod stage under drought treatment compared to salt treatment, indicating a significant interaction between drought and salt stress, reducing the single leaf area and net photosynthetic rate of peanut leaves, ultimately leading to a decrease in peanut yield. Therefore, when planting peanuts in saline alkali soil, drought should be avoided, especially early drought, in order to prevent the combined effects of drought and salt stress from harming peanut yield.