bluuebunny/crossref_metadata_2025 huggingface dataset:
Al–Pt compounds catalyzing the oxygen evolution reaction
Authors: Barrios Jiménez Ana María , Sichevych Olga , Spanos Ioannis , Altendorf Simone G. , Ormeci Alim , Antonyshyn Iryna
Published: January 2023

Al–Pt compounds have been systematically studied under conditions of the oxygen evolution reaction (OER).
Experimental and computational investigation of heteroatom substitution in nucleolytic Cu(ii) cyclen complexes for balancing stability and redox activity
Authors: Hormann Jan , Verbitsky Olga , Zhou Xiaoyu , Battistella Beatrice , van der Meer Margarete , Sarkar Biprajit , Zhao Cunyuan , Kulak Nora
Published: January 2023

Cu(ii) complexes of heteroatom-substituted cyclen-based ligands were optmizied regarding their redox activity and DNA cleavage activity. The ideal ligand exhibited a balanced set of hard and soft donors (CuL6 with N, O and S donor atoms).
Aqua-friendly organometallic Ir–Pt complexes: pH-responsive AIPE-guided imaging of bacterial cells
Authors: Borah Sakira Tabassum , Das Bishnu , Biswas Prakash , Mallick Amirul I. , Gupta Parna
Published: January 2023

In this work, the aggregation-induced photoluminescence emission (AIPE) of three water-soluble heterobimetallic Ir–Pt complexes was reported with insight into their photophysical and electrochemical properties and imaging of bacterial cells.
Electric-field-driven interfacial trapping of drifting triboelectric charges via contact electrification
Authors: Kim Jin-Kyeom , Han Gi Hyeon , Kim Sun-Woo , Kim Hee Jun , Purbia Rahul , Lee Dong-Min , Kim Jong Kyu , Hwang Hee Jae , Song Hyun-Cheol , Choi Dukhyun , Kim Sang-Woo , Wang Zhong Lin , Baik Jeong Min
Published: January 2023

A new facile strategy to maximize the charge density over 1000 μC m−2 for a high-output TENG is demonstrated by introducing new physics in contact electrification, i.e. ‘Electric-field-driven interfacial trapping of drifting triboelectric charges’.
Congo red protects bacteriophages against UV irradiation and allows for the simultaneous use of phages and UV for membrane sterilization
Authors: Wdowiak Mateusz , Mierzejewski Patryk A. , Zbonikowski Rafał , Bończak Bartłomiej , Paczesny Jan
Published: January 2023

Congo red dye protects bacteriophages from the adverse effects of UV radiation, allowing for simultaneous membrane surface cleaning from biofoundries.
Welcome to the inaugural issue of Sustainable Food Technology
Authors: Barros Velazquez Jorge , Rulka Anna
Published: January 2023

Editor-in-Chief Professor Jorge Barros Velazquez and Executive Editor Dr Anna Rulka introduce the inaugural issue of Sustainable Food Technology.
H-Bonding leading to latent initiators for olefin metathesis polymerization
Authors: Brotons-Rufes Artur , Bahri-Laleh Naeimeh , Poater Albert
Published: January 2023

Ruthenium–NHC based catalysts, with a chelated iminium ligand trans to the NHC ligand that polymerize DCPD at different temperatures are studied using DFT calculations to unveil the reaction mechanism.
Efficient photoelectrochemical Kolbe C–C coupling at BiVO4 electrodes under visible light irradiation
Authors: Swansborough-Aston William A. , Soltan Ayman , Coulson Ben , Pratt Andrew , Chechik Victor , Douthwaite Richard E.
Published: January 2023

Under illumination with 450 nm light, porous BiVO4 photoelectrodes support photoeletrochemical Kolbe coupling with up to near quantitative faradaic efficiency and apparent quantum yield of 12% at applied voltages <2 V.
Magnetically controlled flexible micro-robots based on magnetic particle arrangement
Authors: Tang Zhifa , Xu Zhiqiang , Bo Xinqian , Chen Feng , Wu Heng , Li Zhixiong , Jiang Shengqiang
Published: January 2023

This paper reports a simplified method for preparing magnetically controlled flexible robots with swimming, transport, and grasping functions.
Controllable formation of amorphous structure to improve the oxygen evolution reaction performance of a CoNi LDH
Authors: Ye You , Shan Yan , Zhu Hongli , Chen Kezheng , Yu Xuegang
Published: January 2023

This work reports a facile method of introducing a controllable amorphous structure on CoNi layer double hydroxide (CoNi-LDH) through electrooxidation, which effectively improves the oxygen evolution reaction performance of the LDH.
A review on development of metal–organic framework-derived bifunctional electrocatalysts for oxygen electrodes in metal–air batteries
Authors: Javed Najla , Noor Tayyaba , Iqbal Naseem , Naqvi Salman Raza
Published: January 2023

This review paper is based on importance of metal–organic framework-derived bifunctional electrocatalysts for oxygen electrodes in metal–air batteries (MABs), related to the Oxygen Reduction Reaction (ORR) and Oxygen Evolution Reaction (OER).
Simultaneous passivation on both A and X sites of halogen perovskite with magnesium benzoate
Authors: Xu Chenxin , Liu Lujie , Huang Yurong , Zhang Fei , Cao Hui
Published: January 2023

Magnesium benzoate as a surface passivation molecule could simultaneously passivate the A and X sites in the perovskite surface, effectively boosting the performance of the device.
Half-metallic antiferromagnets induced by non-magnetic adatoms on bilayer silicene
Authors: Ouyang Xiao-Fang , Zhang Yu-Zhong , Wang Lu , Liu De-Sheng
Published: January 2023

Half-metallicity could be realized by deposition of non-magnetic atoms on a layered two-dimensional material with an interlayer antiferromagnetic state. After connecting the left and right electrodes, spin polarized current can be output.
A novel and sensitive ratiometric fluorescent quantum dot-based biosensor for alkaline phosphatase detection in biological samples via the inner-filter effect
Authors: Hu Penghui , Huang Ruiyan , Xu Ye , Li Tengfei , Yin Jun , Yang Yu , Liang Yuan , Mao Xiaohan , Ding Li , Shu Chang
Published: January 2023

Schematic representation of ALP activity detection based on a ratiometric fluorescent biosensor in biological samples via an inner-filter effect.
Electrochemically reduced graphene oxide (ERGO)-Cu bilayer structure fabricated at room temperature for future interconnects
Authors: Tian Yuan , Han Silin , Chen Peixin , Cao Liang , Hu Anmin , Li Ming , Wu Yunwen
Published: January 2023

In this paper, a novel electrochemical method is used to further lower the preparation temperature of graphene-Cu bilayer structures to room temperature. An MPTS-modified layer is used to improve the overall electrical performance indirectly.
What happens when chitin becomes chitosan? A single-molecule study
Authors: Qian Lu , Zhang Kai , Guo Xin , Yu Miao
Published: January 2023

Single molecule studies showed that the hydrogen (H)-bonds'state, which can be influenced by the solvent, determines the degree of binding water of polysaccharides.
Investigating the photosensitization activities of flavins irradiated by blue LEDs
Authors: Ribes Jonathan , Cossard Pauline , Al Yaman Khaled , Bestel Isabelle , Badarau Eduard
Published: January 2023

A method for conducting structure-photosensitizing activity relationships for natural flavins and their analogues is described. Several key parameters were investigated: pH, atmosphere, irradiation time & source power.
Two-dimensional H– and F–BX (X = O, S, Se, and Te) photocatalysts with ultrawide bandgap and enhanced photocatalytic performance for water splitting
Authors: Lu Qiang , Chen Xiaowei , Zhang Bofeng , Lin Jiahe
Published: January 2023

We theoretically propose a type of monolayer structure, H– or F–BX (X = As, Sb; Y = P, As), produced by surface hydrogenation or fluorination, with high stability, large band structures and high light absorption for photocatalytic water splitting.
What is necessary to fill the technological gap to design sustainable dye-sensitized solar cells?
Authors: Spinelli Giovanni , Freitag Marina , Benesperi Iacopo
Published: January 2023

Analysis of properties and data – both known and missing – related to materials selection, life cycle assessment, and end-of-life reuse and recycling options for device components to achieve a sustainable design of dye-sensitized solar cells.
Conversion of CO2 to gasoline over tandem Fe/C and HZSM-5 catalysts
Authors: Jin Ke , Wen Chengyan , Jiang Qian , Zhuang Xiuzheng , Chen Lungang , Ma Longlong , Wang Chenguang , Zhang Qi
Published: January 2023

Thermal catalytic conversion of CO2 to produce high-value gasoline is a promising and sustainable way to deal with greenhouse gases and alleviate the energy crisis and environmental problems.
Sustainable production of styrene from catalytic recycling of polystyrene over potassium promoted Fe–Al2O3 catalyst
Authors: Joshi Bhanu , Raghav Himanshu , Agrawal Ankit , Vempatapu Bhanu Prasad , Ray Anjan , Sarkar Bipul
Published: January 2023

The catalytic degradation of polystyrene into styrene was comprehensively studied over solid acid–base catalysts.
Transient deformation and swelling of paper by aqueous co-solvent solutions
Authors: Wong C.-L. , Wang S. , Karimnejad S. , Wijburg M. G. , Mansouri H. , Darhuber A. A.
Published: January 2023

Inkjet printing inks contain polar liquids of low volatility such as glycerol, besides the main solvent water. Monitoring the expansion of paper substrates after ink deposition provides insight into the pore-fiber distribution of such co-solvents.
Nanosheet–hydrogel composites: from preparation and fundamental properties to their promising applications
Authors: Guo Rongrong , Yu Deshuai , Wang Sen , Fu Lianlian , Lin Youhui
Published: January 2023

Nanosheet hydrogels are an important class of soft materials with elastic and intelligent properties.
Supercritical carbon dioxide/nitrogen/air extraction with multistage stripping enables selective recovery of rare earth elements from coal fly ashes
Authors: Zhu Yaguang , Wang Guangcheng , Jun Young-Shin
Published: January 2023

Using supercritical fluids, our novel process selectively extracts rare earth elements from coal fly ashes that were previously considered as waste and an environmental threat.
Upcycling of textile waste into high added value cellulose porous materials, aerogels and cryogels
Authors: Négrier Marion , El Ahmar Elise , Sescousse Romain , Sauceau Martial , Budtova Tatiana
Published: January 2023

Aerogels and cryogels were obtained from cellulose-based textile waste.
Effects of state filling and localization on chemical expansion in praseodymium-oxide perovskites
Authors: Yong Adrian Xiao Bin , Anderson Lawrence O. , Perry Nicola H. , Ertekin Elif
Published: January 2023

Computational study of Pr-based perovskites supported by experiments uncovering insights and design principles for chemical expansion. Hole location on oxygen is highlighted as a route to achieving near-zero chemical expansion.
Stability and efficiency improvement of perovskite solar cells by surface hydroxyl defect passivation of SnO2 layer with 4-fluorothiophenol
Authors: Jeon Yun-Sung , Kang Dong-Ho , Kim Jeong-Hyeon , Park Nam-Gyu
Published: January 2023

Chemical bath-deposited SnO2 widely used as an electron transport layer has hydroxyl defect, which is responsible for degradation of perovskite solar cell. Surface passivation of SnO2 with 4-fluorothiophenol improves stability.
A comparative overview of MXenes and metal oxides as cocatalysts in clean energy production through photocatalysis
Authors: Nair Mahesh M. , Iacoban Alexandra C. , Neaţu Florentina , Florea Mihaela , Neaţu Ştefan
Published: January 2023

The performance of metal oxide and MXene cocatalysts for the photocatalytic conversion of H2O, CO2 and N2 over semiconductors are summarised and compared.
A supramolecular electrode with high self-healing efficiency at room temperature, recyclability and durability for dielectric elastomer generators
Authors: Zang Wenpeng , Jin Sijin , Fu Shuxiong , Wang Yuhao , Jiang Yingjie , Liu Xueying , Ning Nanying , Tian Ming , Zhang Liqun
Published: January 2023

An electrode for DEGs is prepared, which has high conductivity stability, low energy loss and high room temperature self-healing efficiency.
1,4-Azaborine based unfused non-fullerene acceptors for organic solar cells
Authors: Chen Shihao , Dong Minghao , Bai Yuanqing , Chen Yuting , Fu Yuang , Shao Lin , Lu Xinhui , Liu Chunchen , Zhang Kai , Wu Hongbin , Huang Fei
Published: January 2023

Two novel unfused acceptors, ABBT-BO(DT), featuring 1,4-azaborine have been synthesized. ABBT-BO based OSCs achieved an optimal PCE of over 10% for higher exciton dissociation, improved carrier transport and suppressed charge recombination.
Semiconductor quantum dots: a versatile platform for photoredox organic transformation
Authors: Wu Hui-Li , Qi Ming-Yu , Tang Zi-Rong , Xu Yi-Jun
Published: January 2023

A summary of the research progress of diverse organic transformations over semiconductor quantum dot based photofunctional catalysts is provided.
Tellurium/polymers for flexible thermoelectrics: status and challenges
Authors: Jin Linghua , Hao Yabin , Tareen Ayesha Khan , Khan Karim , Wageh Swelm , Al-Hartomy Omar A. , Al-Sehemi Abdullah G. , Zhang Han , Zhang Ye
Published: January 2023

The most studied thermoelectric element is tellurium (Te) because of its high Seebeck coefficient and low lattice thermal conductivity. Combining nanostructured Te with flexible polymers can be an effective strategy for flexible thermoelectrics.
Rapid preparation of a self-adhesive PAA ionic hydrogel using lignin sulfonate–Al3+ composite systems for flexible moisture-electric generators
Authors: Zhang Jinchao , Zhuang Jingshun , Lei Lirong , Hou Yi
Published: January 2023

A self-adhesive PAA ionic hydrogel was used to fabricate highly efficient and flexible moisture-induced electricity generators, which can directly harvest electrical energy from atmospheric moisture.
Review: applications of the functional photocatalysts BiOX (X = Cl, Br, I) for clean energy, the environment, and future photobiorefineries
Authors: Ali Zulfiqar , Ma Jiliang , Hong Min , Sun Runcang
Published: January 2023

Innovations and applications of functional material BiOX photocatalysts.
Ultra-stable CsPbBr3@PbBrOH nanorods for fluorescence labeling application based on methylimidazole-assisted synthesis
Authors: Guan Jie , Yang Dandan , Ma Junyi , Shen Yingzhuo , Xu Qin , Hu Xiaoya
Published: January 2023

CsPbBr3@PbBrOH nanorods with super stability and outstanding luminous performance are prepared through synergy of using a sole 2-methylimidazole ligand and a water-assisted strategy, and are used in fluorescence labeling for novel immunoassay.
Orthogonal light-triggered multiple effects based on photochromic nanoparticles for DNA cleavage and beyond
Authors: Jiao Lizhi , Li Qisi , Li Chenming , Gu Jinhui , Liu Xinping , He Shuijian , Zhang Zhijun
Published: January 2023

An orthogonal light-triggered photochromic nano-system was developed for efficient DNA cleavage, which exhibited promising activity in the treatment of cancer cells and bacterial biofilms.
Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA–RNA building blocks for the multi-analysis of miRNAs
Authors: Duan Chengjie , Chen Yan , Hou Zhiqiang , Li Dayong , Jiao Jin , Sun Weihao , Xiang Yang
Published: January 2023

Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA–RNA building blocks for the multi-analysis of miRNAs.
Multiwavelength hot-band excited triplet–triplet annihilation upconversion with Pt(ii)porphyrin complex/9,10-bis(phenylethynyl)anthracene and multiple encryption information applications
Authors: Chen Quanlun , Ye Changqing , Wan Shigang , Chen Shuoran , Liang Zuoqin , Li Lin , Shi Yizhong , Wang Xiaomei
Published: January 2023

Multiwavelength hot-band excited low-powered upconversion was accomplished with the excitation of a sensitizer at hot-band vibrational energy levels in the ground state, and provides a new way of transcending traditional absorption law restriction.
Constructing MXene hydrogels and aerogels for rechargeable supercapacitors and batteries
Authors: Xi Wen , Zhang Youfang , Zhang Junpu , Wang Rui , Gong Yansheng , He Beibei , Wang Huanwen , Jin Jun
Published: January 2023

This review mainly introduces and discusses the recent progress of MXene hydrogels and aerogels, focusing on their synthesis strategy, applications, challenges and perspectives in rechargeable supercapacitors and batteries.
Optical control of alignment and patterning in an azobenzene liquid crystal photoresist
Authors: Carroll Gregory T. , Lee Kyung Min , McConney Michael E. , Hall Harris J.
Published: January 2023

This report describes a liquid crystalline material that can be cured and patterned with green light and photoaligned with blue light.
Compact CPL emitters based on a [2.2]paracyclophane scaffold: recent developments and future perspectives
Authors: Felder Simon , Delcourt Marie-Leonie , Contant Damian , Rodríguez Rafael , Favereau Ludovic , Crassous Jeanne , Micouin Laurent , Benedetti Erica
Published: January 2023

This perspective discusses the synthesis and (chir)optical properties of compact luminophores derived from [2.2]paracyclophane useful as building blocks for the development of CPL emitters.
NIR-sensing ambipolar organic phototransistors with conjugated terpolymer layers based on diketopyrrolopyrrole-benzothiadiazole-naphthalenediimide comonomer units
Authors: Cho Yeonhwa , Kim Taehoon , Lee Woongki , Kim Hwajeong , Kim Youngkyoo
Published: January 2023

Ambipolar organic phototransistors with terpolymer sensing channel layers (PDPP-8OBT-NDI) deliver well-balanced and high NIR sensitivity of 413% (p-channel) and 373% (n-channel) at λ = 905 nm.
Tough hydrogel–elastomer hybrids hydrophobically regulated by an MXene for motion monitoring in harsh environments
Authors: Dai Shengping , Hu Hongwei , Zhang Yixin , Xu Jiang , Zhong Yan , Cheng Guanggui , Ding Jianning
Published: January 2023

The introduction of MXene improves hydrophobic properties and enhance the hydrophobic encapsulation effect of a hydrogel. It can effectively prevent the influence of external moisture on the hydrogel, enabling outstanding sensing stability performance in harsh environments.
Construction of a two-dimensional metal–organic framework with perpendicular magnetic anisotropy composed of single-molecule magnets
Authors: Aratani Ikumi , Horii Yoji , Takajo Daisuke , Kotani Yoshinori , Osawa Hitoshi , Kajiwara Takashi
Published: January 2023

A robust network structure of single-molecule magnets that exhibits perpendicular magnetic anisotropy preferred for memory devices was constructed utilizing coordination chemistry at the air–liquid interface.
Facile fabrication of exfoliated g-C3N4/MWCNTs/Fe3O4 ternary composites with multi-component functional synergy for high-performance microwave absorption
Authors: Liu Huan , Wu Shengjin , Wang Qihong , Zheng Zongrui , Zhao Hao , Zhao Yulai , Xiao Longqiang , Cai Jingyu , Lu Zhen , Yin Xiangyu , Hou Linxi
Published: January 2023

A facile synthesis strategy of multi-component functional synergy absorbers with a minimum reflection loss value (RLmin) of −51.74 dB at only 1.9 mm (11.12 GHz) and the efficient absorption bandwidth (EAB) of 4.28 GHz at 1.4 mm.
Investigation of isomerization effects on the photovoltaic performance of fused-ring electron acceptors via side-chain position manipulation
Authors: Wang Ke , He Dan , Jiang Li , Wang Chunru , Zhao Fuwen
Published: January 2023

Three fused-ring electron acceptor isomers are developed to study the effect on photovoltaic performance. Among them, IUIC-mid based device has the lowest trap density and finest morphology, thus gaining the highest power conversion efficiency.
Exploring the mechanism of Cassiae semen in regulating lipid metabolism through network pharmacology and experimental validation
Authors: Huang Lili , Zhu Haiyan , Tang Yuqin , Luo Zheng , Xia Luyun , Zhang Chunjiang , Wang Yanqiu , Huai Wenying , Fang Zhiyan , Li Shenrong , Yan Zhiyong , Yin Qiaozhi , Zhang Tian-e
Published: January 2023

Background: Multiple studies have assessed the role of Cassiae semen (CS) in regulating lipid metabolism. However, the mechanism of action of CS on non-alcoholic fatty liver disease (NAFLD) has seen rare scrutiny. Objective: The objective of this study was to explore the regulatory mechanism of CS on lipid metabolism in NAFLD. Methods: Components of CS ethanol extract (CSEE) were analyzed and identified using UPLC-Q-Orbirap HRMS. The candidate compounds of CS and its relative targets were extracted from the Traditional Chinese Medicine Systems Pharmacology, Swiss-Target-Prediction, and TargetNet web server. The Therapeutic Target Database, Genecards, Online Mendelian Inheritance in Man, and DisGeNET were searched for NAFLD targets. Binding affinity between potential core components and key targets was established employing molecular docking simulations. After that, free fatty acid (FFA)-induced HepG2 cells were used to further validate part of the network pharmacology results. Results: Six genes, including Caspase 3 (CASP3), phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α (PIK3CA), epidermal growth factor receptor (EGFR), and amyloid β (A4) precursor protein (APP) were identified as key targets. The mitogen-activated protein kinase (MAPK) signaling pathway was found to associate closely with CS’s effect on NAFLD. Per molecular docking findings, toralactone and quinizarin formed the most stable combinations with hub genes. About 0.1 (vs. FFA, P<0.01) and 0.2 (vs. FFA, P<0.05) mg/ml CSEE decreased lipid accumulation in vitro by reversing the up-regulation of CASP3, EGFR, and APP and the down-regulation of PIK3CA. Conclusion: CSEE can significantly reduce intracellular lipid accumulation by modulating the MAPK signaling pathway to decrease CASP3 and EGFR expression.
From seeds to trees: how E2 enzymes grow ubiquitin chains
Authors: Middleton Adam J. , Day Catherine L.
Published: January 2023

Modification of proteins by ubiquitin is a highly regulated process that plays a critical role in eukaryotes, from the construction of signalling platforms to the control of cell division. Aberrations in ubiquitin transfer are associated with many diseases, including cancer and neurodegenerative disorders. The ubiquitin machinery generates a rich code on substrate proteins, spanning from single ubiquitin modifications to polyubiquitin chains with diverse linkage types. Central to this process are the E2 enzymes, which often determine the exact nature of the ubiquitin code. The focus of this mini-review is on the molecular details of how E2 enzymes can initiate and grow ubiquitin chains. In particular, recent developments and biochemical breakthroughs that help explain how the degradative E2 enzymes, Ube2s, Ube2k, and Ube2r, generate complex ubiquitin chains with exquisite specificity will be discussed.
Use of invertebrates to model chemically induced parkinsonism-symptoms
Authors: Correa Clynton Lourenço , de Andrade Gomes Carlos Augusto Borges , Mello Andressa de Abreu , Nogueira Nathany da Silva , Medeiros Taiane Barreto , de Barros Cintia Monteiro , Allodi Silvana
Published: January 2023

The prevalence of neurological diseases is currently growing due to the combination of several factor, including poor lifestyle and environmental imbalance which enhance the contribution of genetic factors. Parkinson's disease (PD), a chronic and progressive neurological condition, is one of the most prevalent neurodegenerative human diseases. Development of models may help to understand its pathophysiology. This review focuses on studies using invertebrate models to investigate certain chemicals that generate parkinsonian-like symptoms models. Additionally, we report some preliminary results of our own research on a crustacean (the crab Ucides cordatus) and a solitary ascidian (Styela plicata), used after induction of parkinsonism with 6-hydroxydopamine and the pesticide rotenone, respectively. We also discuss the advantages, limits, and drawbacks of using invertebrate models to study PD. We suggest prospects and directions for future investigations of PD, based on invertebrate models.
Targeted bisulfite resequencing of differentially methylated cytosines in pre-eclampsia reveals a skewed dynamic balance in the DNA methylation of enhancers
Authors: Zheng Xiaoguo , Wu Weibin , Zhou Qian , Lian Yahan , Xiang Yuqian , Zhao Xinzhi
Published: January 2023

Pre-eclampsia (PE) is a major hypertensive disorder of pregnancy. Widespread differentially methylated cytosines (DMCs) with modest changes in methylation level are associated with PE, whereas their cause and biological significance remain unknown. We aimed to clarify DNA methylation patterns around DMCs in 103 placentas using MethylCap targeted bisulfite re-sequencing (MethylCap-seq) assays of 690 selected DMCs. We verified the MethylCap-seq method, then validated 677 (98.1%) of DMCs (vDMCs) in an independent cohort. The validated DMCs were strongly enriched in active placenta-specific enhancers and showed highly dynamic methylation levels. We found high epigenetic heterogeneity between vDMCs and adjacent CpG sites (r2 < 0.2) and a significant decrease in PE in the discovery and replication cohorts (P = 2.00 × 10−24 and 6.43 × 10−9, respectively). We replicated the methylation changes in a hypoxia/reoxygenation cell model. We constructed 112 methylation haplotype blocks and found that the frequencies of unmethylated haplotypes (UMHs) were dynamic with gestational age (GA) and were altered in maternal plasma of patients with PE. Our results uncovered additional DNA methylation features in PE placentas and suggested a model of skewed DNA methylation balance of enhancers in PE.
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?
Authors: Fernández-Moncada Ignacio , Marsicano Giovanni
Published: January 2023

Astrocytes are key players in brain homeostasis and function. During the last years, several studies have cemented this notion by showing that these cells respond to neuronal signals and, via the release of molecules that modulate and support synaptic activity (gliotransmission) participates in the functions of the so-called tripartite synapse. Thus, besides their established control of brain metabolism, astrocytes can also actively control synaptic activity and behavior. Among the signaling pathways that shape the functions of astrocyte, the cannabinoid type-1 (CB1) receptor is emerging as a critical player in the control of both gliotransmission and the metabolic cooperation between astrocytes and neurons. In the present short review, we describe known and newly discovered properties of the astroglial CB1 receptors and their role in modulating brain function and behavior. Based on this evidence, we finally discuss how the functions and mode of actions of astrocyte CB1 receptors might represent a clear example of the inextricable relationship between energy metabolism and gliotransmission. These tight interactions will need to be taken into account for future research in astrocyte functions and call for a reinforcement of the theoretical and experimental bridges between studies on metabolic and synaptic functions of astrocytes.
Self-Perception of Cognitive-Communication Functions After Mild Traumatic Brain Injury
Authors: Norman Rocio , Flaugher Tara , Chang Sharon , Power Emma
Published: January 2023

Purpose:

A mixed-method approach was used to investigate the lived experiences of adults with mild traumatic brain injury (mTBI). The study aimed to understand the perceived relationship between cognitive-communication problems, thinking and communication concerns, and neurobehavioral symptoms. We hypothesized that individuals with cognitive-communication problems would attribute their problems with communication to their mTBI history and their self-perceived problems would be correlated with symptomatology.

Method:

The Neurobehavioral Symptom Inventory (NSI) and an online cognitive-communication survey was used to conduct a study of 30 adults with mTBI history. Quantitative survey and NSI scores were analyzed with content analysis and correlational statistics.

Results:

The average NSI Total score was 17 with the following subscale scores: somatic (5), affective (8), and cognitive (3.9). Participants reported problems with expressive communication (56%), comprehension (80%), thinking (63%), and social skills (60%). Content analysis revealed problems in the following areas: expression (e.g., verbal, and written language), comprehension (reading and verbal comprehension), cognition (e.g., attention, memory and speed of processing, error regulation), and functional consequences (e.g., academic work, social problems, and anxiety and stress). A Pearson correlation indicated a statistically significant relationship (
p
< .01) between the Communication Survey Total and the Total, Somatic, Affective, and Cognitive subscales.

Conclusions:

This study highlights a multifactorial basis of cognitive-communication impairment in adults with mTBI. We show that those with mTBI history perceive difficulties with cognitive-communication skills: conversations, writing, and short-term memory/attention. Furthermore, those with mTBI perceive their cognitive-communication problems after injury have impacted their vocational, social, and academic success.
An X/Ku band phase shifter with filter compensation technology
Authors: Zeng Jialong , Yu Zhongjun , Yuan Yang , Li Jiaxuan , Zhang Desheng
Published: January 2023

This letter proposes an ultra‐wideband switched T‐type phase shifter, which covers the whole X/Ku band. The proposed switched T‐type phase shifter integrates a switched filter compensation structure, achieving a flat relative phase shift in broadband, which the conventional one cannot acquire. In addition, the designed T‐type phase shifter can further reduce the phase error and improve the phase shift capability with a phase shift greater than 45°. Employing the proposed architecture, a 90° T‐type phase shifter is designed and fabricated in 0.15‐μm GaAs pHEMT process. The measured results show that the proposed T‐type phase shifter achieves a stable 90° phase shift at 8 to 18 GHz with a phase error of less than ±2°, and an insertion loss (IL) of 2.4 to 4.2 dB. And the chip size of the switched T‐type phase shifter is 0.62 × 0.75 mm2. Thanks to its good performance, the proposed T‐type phase shifter is very suitable for various radar and satellite communication systems.
A severely range ambiguous clutter suppression method based on multi‐domain cascaded signal processing for space‐based early warning radar
Authors: Zhang Tianfu , Wang Zhihao , Xing Mengdao , Zhang Shuangxi , Wang Yongliang
Published: January 2023

The non‐stationary clutter phenomenon and the severe range ambiguity make space‐based early warning radar as an intricate model of received ground and sea clutter. The received clutter is severely broadened in Doppler dimension, and the degrees of freedom (DOFs) of the received clutter is severely increased. Because the DOFs of the system is always lower than the theoretical DOFs of the received clutter, the adaptive processing capability of the system is insufficient and the performance of clutter suppression is seriously degraded. A multi‐domain cascaded adaptive processing method is proposed in this study. The proposed method takes full advantage of the digital antenna array to suppress a portion of the clutter energy by introducing the transmit pulse coding domain, and the remaining influential clutter energy is suppressed by introducing the elevation‐dimensional receive channel domain. Finally, the clutter after the two‐dimensional (2D) pre‐processed is suppressed by the 2D adaptive processing in the azimuthal receive beam‐receive Doppler domain. This method pre‐processes the clutter data by extending the processing dimension to meet the freedom requirements of the adaptive signal processing, and the capability of clutter suppression is significantly improved. Simulation examples show the effectiveness of the proposed method.
Combining HIPPARCOS and Gaia data for the study of binaries: The BINARYS tool
Authors: Leclerc A. , Babusiaux C. , Arenou F. , van Leeuwen F. , Bonnefoy M. , Delfosse X. , Forveille T. , Le Bouquin J.-B. , Rodet L.
Published: January 2023

Context. Orbital motion in binary and planetary systems is the main source of precise stellar and planetary mass measurements, and the joint analysis of data obtained using multiple observational methods can both lift degeneracies and improve precision.

Aims. We set out to measure the masses of individual stars in binary systems using all the information brought by the HIPPARCOS and Gaia absolute astrometric missions.

Methods. We present BINARYS, a tool that uses the HIPPARCOS and Gaia absolute astrometric data and combines them with relative astrometry and/or radial velocity measurements to determine the orbit of a binary system. This tool rigorously combines the HIPPARCOS and Gaia data (here EDR3) and can use the HIPPARCOS Transit Data as needed for binaries where HIPPARCOS detects significant flux from the secondary component. It also supports the case where Gaia has resolved the system, giving an astrometric solution for both components.

Results. We determine model-independent individual masses for the first time for three systems: the two mature binaries Gl 494 (M1 = 0.584 ± 0.003 M⊙ and M2 = 87 ± 1 MJup) and HIP 88745 (M1 = 0.96 ± 0.02 M⊙ and 0.62-0.008+0.009 ), and the younger AB Dor member GJ 2060 (1926-6+7 and 0.882 -0.005+0.004). The latter provides a rare test of evolutionary model predictions at young ages in the low-stellar-mass range and sets a lower age limit of 100 Myr for the moving group.
The nebula around the binary post-AGB star 89 Herculis
Authors: Gallardo Cava I. , Alcolea J. , Bujarrabal V. , Gómez-Garrido M. , Castro-Carrizo A.
Published: January 2023

Context. There is a class of binary post-asymptotic giant branch (post-AGB) stars that exhibit remarkable near-infrared (NIR) excess. These stars are surrounded by disks with Keplerian or quasi-Keplerian dynamics and outflows composed of gas escaping from the rotating disk. Depending on the dominance of these components, there are two subclasses of binary post-AGB stars: disk-dominated and outflow-dominated.

Aims. We aim to properly study the hourglass-like structure that surrounds the Keplerian disk around 89 Her.

Methods. We present total-power on-the-fly maps of 12CO and 13CO J = 2 − 1 emission lines in 89 Her. Previous studies are known to suffer from flux losses in the most extended components. We merge these total-power maps with previous NOEMA maps. The resulting combined maps are expected to detect the whole nebula extent of the source.

Results. Our new combined maps contain the entirety of the detectable flux of the source and at the same time are of high spatial resolution thanks to the interferometric observations. We find that the hourglass-like extended outflow around the rotating disk is larger and more massive than suggested by previous works. The total nebular mass of this very extended nebula is 1.8 × 10−2 M⊙, of which ∼65% comes from the outflow. The observational data and model results lead us to classify the envelope around 89 Her as an outflow-dominated nebula, together with R Sct and IRAS 19125+0343 (and very probably AI CMi, IRAS 20056+1834, and IRAS 18123+0511). The updated statistics on the masses of the two post-AGB main components reveal that there are two distinct subclasses of nebulae around binary post-AGB stars depending on which component is the dominant one. We speculate that the absence of an intermediate subclass of sources is due to the different initial conditions of the stellar system and not because both subclasses are in different stages of the post-AGB evolution.
Modelling shock-like injections of solar energetic particles with 3D test particle simulations
Authors: Hutchinson A. , Dalla S. , Laitinen T. , Waterfall C. O. G.
Published: January 2023

Context. Solar energetic particle (SEP) acceleration and injection into interplanetary space during gradual SEP events is thought to take place at coronal mass ejection (CME)-driven shocks. Various features of measured intensity profiles at 1 au have been attributed to properties of the radial, longitudinal, and latitudinal SEP injections at the shock. Focussed transport models are typically used to model acceleration at a CME-shock and subsequent propagation. Test particle simulations are an alternative approach but so far they have been carried out only with instantaneous injection near the Sun.

Aims. We develop the first temporally extended shock-like injection for our 3D test particle code and investigate how the spatial features of injection at a shock affect SEP intensity and anisotropy profiles for observers at 0.3 and 1.0 au.

Methods. We conducted simulations of a monoenergetic population of 5 MeV protons considering three different radial injection functions and two longitudinal and latitudinal injection functions. We considered a range of scattering conditions with scattering mean free path values ranging from λ = 0.1 − 1.0 au, and determined intensity and anisotropy profiles at six observers at different longitudinal locations.

Results. We find that the radial, longitudinal, and latitudinal injection functions play a relatively minor role in shaping the SEP intensity profiles. The dependence of intensity profiles on the value of the scattering mean free path is also weak, unlike what is found from 1D focussed transport models. Spatial factors, such as the times of observer-shock connection and disconnection as well as the time of shock passage have a much stronger influence on SEP intensities and anisotropies. Persistent anisotropies, until shock passage, are seen in our simulations. Comparing instantaneous and shock-like injections, we find that the link between the duration of injection and the duration of the SEP event is very weak, unlike what is commonly assumed.
Continuum limit ofp-Laplacian evolution problems on graphs:Lqgraphons and sparse graphs
Authors: El Bouchairi Imad , Fadili Jalal M. , Elmoataz Abderrahim
Published: January 2023

In this paper we study continuum limits of the discretizedp-Laplacian evolution problem on sparse graphs with homogeneous Neumann boundary conditions. This goes far beyond known results by handling much more general class of kernels, possibly singular, and graph sequences whose limit are the so-calledLq-graphons. More precisely, we derive a bound on the distance between two continuous-in-time trajectories defined by two different evolution systems (i.e., with different kernels, second member and initial data). Similarly, we provide a bound in the case that one of the trajectories is discrete-in-time and the other is continuous. In turn, these results lead us to establish error estimates of the full discretization of thep-Laplacian problem on sparse random graphs. In particular, we provide rate of convergence of solutions for the discrete models to the solution of the continuous problem as the number of vertices grows.
Could virtual volunteerism enhance information resilience in a nuclear emergency? The potential role of disaster knowledge workers and virtual emergent groups
Authors: Raisio H. , Puustinen A. , Lindell J. , Wiikinkoski T. , Valtonen V.
Published: January 2023

Informal volunteerism in its various forms is on the rise in the safety and security arena. This study focuses on a new mode of informal volunteerism, virtual volunteerism. The study uses the complex context of a nuclear emergency to explore (1) the extent to which informal volunteerism, in the form of virtual volunteerism, can develop information resilience and (2) the problems and challenges involved. The study relies on interview data gathered from 18 Finnish public authorities and NGO actors working in expert or managerial positions connected to nuclear emergency response. The study results suggest that informal virtual volunteerism could play a role in the development of information resilience in the society. However, as suggested in previous studies, virtual volunteerism could be a double-edged sword. There is a real risk of mis- and disinformation because of the volatile times in which we live. The identified risk sparked a debate on the inclusion and exclusion of unaffiliated disaster knowledge workers and virtual emergent groups in nuclear emergency preparedness, response, and recovery.
COVID-19 Vaccines—All You Want to Know
Authors: Shishido Akira A. , Barnes Ashley H. , Narayanan Shivakumar , Chua Joel V.
Published: January 2023

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has led to an unprecedented public health crisis. The collective global response has led to production of multiple safe and effective vaccines utilizing novel platforms to combat the virus that have propelled the field of vaccinology forward. Significant challenges to universal vaccine effectiveness remain, including immune evasion by SARS-CoV-2 variants, waning of immune response, inadequate knowledge of correlates of protection, and dosing in special populations. This review serves as a detailed evaluation of the development of the current SARS-CoV-2 vaccines, their effectiveness, and challenges to their deployment as a preventive tool.
Update on Sepsis Epidemiology in the Era of COVID-19
Authors: Shappell Claire , Rhee Chanu , Klompas Michael
Published: January 2023

Timely and accurate data on the epidemiology of sepsis is essential to inform public policy, clinical practice, and research priorities. Recent studies have illuminated several ongoing questions about sepsis epidemiology, including the incidence and outcomes of sepsis in non-Western countries and in specialized populations such as surgical patients, patients with cancer, and the elderly. There have also been new insights into the limitations of current surveillance methods using administrative data and increasing experience tracking sepsis incidence and outcomes using “big data” approaches that take advantage of detailed electronic health record data. The COVID-19 pandemic, however, has fundamentally changed the landscape of sepsis epidemiology. It has increased sepsis rates, helped highlight ongoing controversies about how to define sepsis, and intensified debate about the possible unintended consequences of overly rigid sepsis care bundles. Despite these controversies, there is a growing consensus that severe COVID-19 causing organ dysfunction is appropriate to label as sepsis, even though it is treated very differently from bacterial sepsis, and that surveillance strategies need to be modified to reliably identify these cases to fully capture and delineate the current burden of sepsis. This review will summarize recent insights into the epidemiology of sepsis and highlight several urgent questions and priorities catalyzed by COVID-19.
Cardiovascular Complications in Coronavirus Disease 2019—Pathogenesis and Management
Authors: Restrepo Marcos I. , Marin-Corral Judith , Rodriguez Juan J. , Restrepo Valeria , Cavallazzi Rodrigo
Published: January 2023

The coronavirus disease 2019 (COVID-19) pandemic has caused a devastating impact on morbidity and mortality around the world. Severe acute respiratory syndrome-coronavirus-2 has a characteristic tropism for the cardiovascular system by entering the host cells and binding to angiotensin-converting enzyme 2 receptors, which are expressed in different cells, particularly endothelial cells. This endothelial injury is linked by a direct intracellular viral invasion leading to inflammation, microthrombosis, and angiogenesis. COVID-19 has been associated with acute myocarditis, cardiac arrhythmias, new onset or worsening heart failure, ischemic heart disease, stroke, and thromboembolic disease. This review summarizes key relevant literature regarding the epidemiology, diagnosis, treatment, and preventive measures related to cardiovascular complications in the setting of COVID-19.
Factors Associated with Transfer Distance from Birth Hospital to Repair Hospital for First Surgical Repair among Infants with Myelomeningocele in California
Authors: Kancherla Vijaya , Ma Chen , Purkey Neha J. , Hintz Susan R. , Lee Henry C. , Grant Gerald , Carmichael Suzan L.
Published: January 2023

Objective The objective of our study was to examine factors associated with distance to care for first surgical repair among infants with myelomeningocele in California.

Study Design A total of 677 eligible cases with complete geocoded data were identified for birth years 2006 to 2012 using data from the California Perinatal Quality Care Collaborative linked to hospital and vital records. The median distance from home to birth hospital among eligible infants was 9 miles, and from birth hospital to repair hospital was 15 miles. We limited our analysis to infants who lived close to the birth hospital, creating two study groups to examine transfer distance patterns: “lived close and had a short transfer” (i.e., lived <9 miles from birth hospital and traveled <15 miles from birth hospital to repair hospital; n = 92), and “lived close and had a long transfer” (i.e., lived <9 miles from birth hospital and traveled ≥15 miles from birth hospital to repair hospital; n = 96). Log-binomial regression was used to estimate crude and adjusted risk ratios (aRRs and 95% confidence intervals (CIs). Selected maternal, infant, and birth hospital characteristics were compared between the two groups.

Results We found that low birth weight (aRR = 1.44; 95% CI = 1.04, 1.99) and preterm birth (aRR = 1.41; 95% CI = 1.01, 1.97) were positively associated, whereas initiating prenatal care early in the first trimester was inversely associated (aRR = 0.64; 95% CI = 0.46, 0.89) with transferring a longer distance (≥15 miles) from birth hospital to repair hospital. No significant associations were noted by maternal race-ethnicity, socioeconomic indicators, or the level of hospital care at the birth hospital.

Conclusion Our study identified selected infant factors associated with the distance to access surgical care for infants with myelomeningocele who had to transfer from birth hospital to repair hospital. Distance-based barriers to care should be identified and optimized when planning deliveries of at-risk infants in other populations.

Key Points
Assessing Barriers to Utilization of Premedication for Neonatal Intubation Based on the Theoretical Domains Framework
Authors: Lee Dianne T. , Bruno Christie J. , Sharifi Mona , Shabanova Veronika , Johnston Lindsay C.
Published: January 2023

Objective This study aimed to identify barriers and facilitators of premedication utilization for nonemergent neonatal intubations (NIs) in a level IV neonatal intensive care unit (NICU).

Study Design Between November 2018 and January 2019, multidisciplinary providers at a level IV NICU were invited to participate in an anonymous, electronic survey based on Theoretical Domains Framework to identify influences on utilization of evidence-based recommendations for NI premedication.

Results Of 186 surveys distributed, 84 (45%) providers responded. Most agreed with premedication use in the following domains: professional role/identity (86%), emotions (79%), skills (72%), optimism (71%), and memory, attention, and decision process (71%). Domains with less agreement include social influences (42%), knowledge (57%), intention (60%), belief about capabilities (63%), and behavior regulation (64%). Additional barriers include environmental context and resources, and beliefs about consequences.

Conclusion Several factors influence premedication use for nonemergent NI and may serve as facilitators and/or barriers. Efforts to address barriers should incorporate a multidisciplinary approach to improve patient outcomes and decrease procedure-related pain.

Key Points