bluuebunny/crossref_metadata_2025 huggingface dataset:
Obstacle Avoidance Path Planning of Space Robot Based on Improved Particle Swarm Optimization
Authors: Zhang Jianxia , Zhang Jianxin , Zhang Qiang , Wei Xiaopeng
Published: May 2022

In order to meet security requirements of space on orbit service, an obstacle avoidance trajectory planning method using improved particle swarm optimization had been presented in this paper. On the basis of the actual overall structure of 7 degrees of freedom redundant space manipulator and the characteristics of obstacles, the envelope method was used to model the arm and obstacles, respectively. The limit conditions to avoid the collision between them were analyzed. Then, the fitness function under the symmetrical conditions of avoiding the collision and searching for the shortest trajectory was constructed. In addition, the obstacle avoidance trajectory planning was solved based on improved particle swarm optimization (IPSO). Finally, simulation experiments were carried out to prove its effectiveness and rationality, where there were symmetrical advantages in two aspects. It can be concluded that the presented method based on IPSO has strong robustness.
A Comparative Analysis of Different Strains of Coronavirus Based on Genometric Mappings
Authors: Stepanyan Ivan V. , Lednev Michail Y.
Published: May 2022

Coronaviruses are viruses that infect the respiratory system of humans. Besides high mortality rates among the population, they brought about several economic crises on a global scale. Methods. To study and identify features in the genetic composition of the nucleotide sequences of various coronaviruses, we applied copyright algorithms and visualization, which allowed us to compare the biochemical parameters of diverse RNA coronaviruses in a visual form. Results. The article provides examples of different approaches to imaging coronaviruses. We have provided examples of coronavirus RNA structure visualization in various parametric spaces (1-D and 2-D). We employed various visualization types, including structural, integral, and frequency. The research discussed methods of visualization. Our team developed visualization and comparative analysis of coronavirus serotypes and visualization of SARS-CoV-2 coronavirus datasets. Discussion followed on the visualization results. The presented techniques and the results allowed for displaying the structure of RNA sequences of coronaviruses in spaces of various dimensions. Conclusions. According to our findings, the proposed method contributes to the visualization of the genetic coding of coronaviruses. We discussed the issues of machine learning and neural network technology concerning the analysis of coronaviruses based on the presented approach. The described line of research is essential for the study and control of complex quantum mechanical systems, such as RNA or DNA.
Machine Learning for Rupture Risk Prediction of Intracranial Aneurysms: Challenging the PHASES Score in Geographically Constrained Areas
Authors: Walther Georg , Martin Christian , Haase Amelie , Nestler Ulf , Schob Stefan
Published: May 2022

Intracranial aneurysms represent a potentially life-threatening condition and occur in 3–5% of the population. They are increasingly diagnosed due to the broad application of cranial magnetic resonance imaging and computed tomography in the context of headaches, vertigo, and other unspecific symptoms. For each affected individual, it is utterly important to estimate the rupture risk of the respective aneurysm. However, clinically applied decision tools, such as the PHASES score, remain insufficient. Therefore, a machine learning approach assessing the rupture risk of intracranial aneurysms is proposed in our study. For training and evaluation of the algorithm, data from a single neurovascular center was used, comprising 446 aneurysms (221 ruptured, 225 unruptured). The machine learning model was then compared with the PHASES score and proved superior in accuracy (0.7825), F1-score (0.7975), sensitivity (0.8643), specificity (0.7022), positive predictive value (0.7403), negative predictive value (0.8404), and area under the curve (0.8639). The frequency distributions of the predicted rupture probabilities and the PHASES score were analyzed. A symmetry can be observed between the rupture probabilities, with a symmetry axis at 0.5. A feature importance analysis reveals that the body mass index, consumption of anticoagulants, and harboring vessel are regarded as the most important features when assessing the rupture risk. On the other hand, the size of the aneurysm, which is weighted most in the PHASES score, is regarded as less important. Based on our findings we discuss the potential role of the model for clinical practice in geographically confined aneurysm patients.
The Prevalence of Porcine Circovirus-like Viruses in China Presents New Challenges to the Diagnosis of Diarrhea-Associated Viruses. Comment on Yang et al. Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021. Viruses 2021, 13, 2282
Authors: Zeng Meng , Ji Chihai , Sun Yuan , Ma Jingyun
Published: May 2022

Recently, a report in Viruses has highlighted the problem of porcine circovirus-like (PCL) virus [...]
The E6 Oncoprotein of HPV16 AA-c Variant Regulates Cell Migration through the MINCR/miR-28-5p/RAP1B Axis
Authors: Perez-Bacho Eduardo Gil , Beltrán-Anaya Fredy Omar , Arechaga-Ocampo Elena , Hernández-Sotelo Daniel , Garibay-Cerdenares Olga Lilia , Illades-Aguiar Berenice , Alarcón-Romero Luz Del Carmen , Del Moral-Hernández Oscar
Published: May 2022

The E6 oncoprotein of HPV16 variants differentially alters the transcription of the genes involved in migration and non-coding RNAs such as lncRNAs. The role of the lncRNA MINCR in cervical cancer and its relationship with variants of oncogenic HPV remain unknown. Therefore, the objective of this study was to analyze the effect of the E6 oncoprotein of the AA-c variant of HPV16 in cell migration through the MINCR/miR-28-5p/RAP1B axis. To explore the functional role of MINCR in CC, we used an in vitro model of C33-A cells with exogenous expression of the E6 oncoprotein of the AA-c variant of HPV16. Interfering RNAs performed MINCR silencing, and the expression of miR-28-5p and RAP1B mRNA was analyzed by RT-qPCR. We found that C33-A/AA-c cells expressed MINCR 8-fold higher compared to the control cells. There is an inverse correlation between the expression of miR-28-5p and RAP1B in C33-A/AA-c cells. Our results suggest that MINCR might regulate the expression of RAP1B through the inhibition of miR-28-5p in CC cells expressing the E6 oncoprotein of HPV16 AA-c. We report, for the first time, that the MINCR/miR-28-5p/RAP1B axis positively regulates cell migration in CC-derived cells that express the E6 oncoprotein of the AA-c variant of HPV16.
A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development
Authors: de Lima Cavalcanti Thaise Yasmine Vasconcelos , Pereira Mylena Ribeiro , de Paula Sergio Oliveira , Franca Rafael Freitas de Oliveira
Published: May 2022

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile illness known as chikungunya fever (CHIKF). Infection is self-limited and characterized mainly by severe joint pain and myalgia that can last for weeks or months; however, severe disease presentation can also occur in a minor proportion of infections. Among the atypical CHIKV manifestations that have been described, severe arthralgia and neurological complications, such as encephalitis, meningitis, and Guillain–Barré Syndrome, are now reported in many outbreaks. Moreover, death cases were also reported, placing CHIKV as a relevant public health disease. Virus evolution, globalization, and climate change may have contributed to CHIKV spread. In addition to this, the lack of preventive vaccines and approved antiviral treatments is turning CHIKV into a major global health threat. In this review, we discuss the current knowledge about CHIKV pathogenesis, with a focus on atypical disease manifestations, such as persistent arthralgia and neurologic disease presentation. We also bring an up-to-date review of the current CHIKV vaccine development. Altogether, these topics highlight some of the most recent advances in our understanding of CHIKV pathogenesis and also provide important insights into the current development and clinical trials of CHIKV potential vaccine candidates.
Use of Pembrolizumab for Treatment of Progressive Multifocal Leukoencephalopathy in People Living with HIV
Authors: Pinnetti Carmela , Cimini Eleonora , Vergori Alessandra , Mazzotta Valentina , Grassi Germana , Mondi Annalisa , Forbici Federica , Amendola Alessandra , Grisetti Susanna , Baldini Francesco , Candela Caterina , Casetti Rita , Campioni Paolo , Capobianchi Maria Rosaria , Agrati Chiara , Antinori Andrea
Published: May 2022

Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating disease occurring in advanced HIV infection, caused by the reactivation of poliomavirus JC (JCV). The use of pembrolizumab for treatment is based on the inhibition of programmed cell death protein 1 (PD-1), potentially improving the anti JCV-specific response. We used pembrolizumab with combined antiretroviral treatment (cART) on a compassionate-use basis. At each administration, clinical evaluation, MRI and laboratory testing, including CD3, CD4, CD8, PD-1 markers, HIV-RNA and JCV-DNA in cerebrospinal fluid (CSF)/plasma pairs, were performed. The JCV-specific T cell response was analysed by Elispot assay. This study included five HIV patients: four male, median age 43 years (29–52), median CD4 and CD8 count 150 (15–158) and 973 (354–1250) cell/mm3, respectively; median JCV-DNA and HIV-RNA in CSF/plasma pairs 9.540/1.503 cps/mL and 2.230/619 cp/mL, respectively. Overall, patients received between two and seven doses of pembrolizumab. After treatment, we observed JCV-DNA reduction and PD-1 down-regulation both in CSF and in plasma (high in circulating CD4 and CD8 at baseline), which remained stable at low levels in all patients. Three out of five patients showed stability of clinical picture and neuroimaging, while two others died. More data are needed in order to identify predictors of response to therapy.
The International Virus Bioinformatics Meeting 2022
Authors: Hufsky Franziska , Beslic Denis , Boeckaerts Dimitri , Duchene Sebastian , González-Tortuero Enrique , Gruber Andreas J. , Guo Jiarong , Jansen Daan , Juma John , Kongkitimanon Kunaphas , Luque Antoni , Ritsch Muriel , Lencioni Lovate Gabriel , Nishimura Luca , Pas Célia , Domingo Esteban , Hodcroft Emma , Lemey Philippe , Sullivan Matthew B. , Weber Friedemann , González-Candelas Fernando , Krautwurst Sarah , Pérez-Cataluña Alba , Randazzo Walter , Sánchez Gloria , Marz Manja
Published: May 2022

The International Virus Bioinformatics Meeting 2022 took place online, on 23–25 March 2022, and has attracted about 380 participants from all over the world. The goal of the meeting was to provide a meaningful and interactive scientific environment to promote discussion and collaboration and to inspire and suggest new research directions and questions. The participants created a highly interactive scientific environment even without physical face-to-face interactions. This meeting is a focal point to gain an insight into the state-of-the-art of the virus bioinformatics research landscape and to interact with researchers in the forefront as well as aspiring young scientists. The meeting featured eight invited and 18 contributed talks in eight sessions on three days, as well as 52 posters, which were presented during three virtual poster sessions. The main topics were: SARS-CoV-2, viral emergence and surveillance, virus–host interactions, viral sequence analysis, virus identification and annotation, phages, and viral diversity. This report summarizes the main research findings and highlights presented at the meeting.
Correlation of Fc Receptor Polymorphisms with Pneumococcal Antibodies in Vaccinated Kidney Transplant Recipients
Authors: Arnold Marie-Luise , Heinemann Falko M. , Oesterreich Simon , Wilde Benjamin , Gäckler Anja , Goldblatt David , Spriewald Bernd M. , Horn Peter A. , Witzke Oliver , Lindemann Monika
Published: May 2022

Several polymorphisms within Fc receptors (FCR) have been described, some of which correlate with allograft function. In the current study, we determined three Fcγ receptor and five Fcα receptor dimorphisms in 47 kidney transplant recipients who had been vaccinated against Streptococcus pneumoniae. We analyzed if FCR genotypes correlated with pneumococcal antibodies and their serotype-specific opsonophagocytic function, tested prior to and at months 1 and 12 post-vaccination. In parallel, we assessed antibodies against HLA and MICA and determined kidney function. We observed that IgG2 antibodies against pneumococci at months 1 and 12 after vaccination and IgA antibodies at month 1 differed significantly between the carriers of the three genotypes of FCGR3A rs396991 (V158F, p = 0.02; 0.04 and 0.009, respectively). Moreover, the genotype of FCGR3A correlated with serotype-specific opsonophagocytic function, reaching statistical significance (p < 0.05) at month 1 for 9/13 serotypes and at month 12 for 6/13 serotypes. Heterozygotes for FCGR3A had the lowest antibody response after pneumococcal vaccination. On the contrary, heterozygotes tended to have more antibodies against HLA class I and impaired kidney function. Taken together, our current data indicate that heterozygosity for FCGR3A may be unfavorable in kidney transplant recipients.
Vagally Associated Second Degree Atrio-Ventricular Block in a Dog with Severe Azotemia and Evidence of Sympathetic Overdrive
Authors: Baisan Radu Andrei , Turcu Andreea Cătălina , Condurachi Eusebiu Ionuț , Vulpe Vasile
Published: May 2022

A 14 years old, 6 kg, mix-breed male dog with severe azotemia due to urinary bladder herniation was presented to our Veterinary Teaching Hospital (VTH). Electrocardiography revealed normal heart rate of 100 bpm, evidence of sinus respiratory arrhythmia (SRA) and frequent second degree atrio-ventricular block following peak inspiratory phase suggestive of vagally-induced atrio-ventricular conduction delay. Echocardiographic examination showed mild mitral regurgitation without any other cardiac changes, and systolic (SAP) and diastolic (DAP) blood pressure values were 185/90 mmHg (SAP/DAP). Cardiac troponin I (cTnI) was increased to 7.3 ng/mL, suggesting a myocardial injury. A Holter examination revealed evidence of overall decrease in heart rate variability with evidence of sympathetic overdrive on time and frequency domain as well as when the non-linear Poincaré plot was analyzed. Based on the author’s knowledge, this is the first report of a second degree atrio-ventricular block associated with vagal activity in a dog, with evidence of sympathetic overdrive and severe azotemia.
Hydrodynamics in Estuaries and Coast: Analysis and Modeling
Authors: Guo Yakun
Published: May 2022

Estuarine and coastal regions are heavily populated and well-developed areas [...]
Estimating Changes in Peak Flow and Associated Reductions in Flooding Resulting from Implementing Natural Infrastructure in the Neuse River Basin, North Carolina, USA
Authors: Kurki-Fox J. Jack , Doll Barbara A. , Line Daniel E. , Baldwin Madalyn E. , Klondike Travis M. , Fox Andrew A.
Published: May 2022

As the frequency of more intense storms increases and concerns grow regarding the use of dams and levees, the focus has shifted to natural infrastructure (NI) for flood mitigation. NI has shown some success at small scales; however, little work has been carried out at the large watershed scale during extreme events. Three NI measures (afforestation, water farming, and flood control wetlands) were evaluated in the Neuse River Basin of eastern North Carolina. Detailed geospatial opportunity and hydrologic modeling of the measures were conducted in three subwatersheds of the basin and results were extrapolated to other subwatersheds. NI opportunity was greater and associated modeled peak flow reductions were larger for two subwatersheds located in the lower portion of the basin, where there is less development and flatter land slopes. Peak flow reductions varied spatially depending on the type and placement of NI combined with the hydraulic and morphologic characteristics of the stream network. Extrapolation of reductions to other subwatersheds produced a 4.4% reduction in peak flow for the 100 year storm at the outlet of the river basin in Kinston as a result of water farming on 1.1%, wetlands controlling runoff from 5.7%, and afforestation of 8.4% of the river basin.
A Flood Risk Management Model to Identify Optimal Defence Policies in Coastal Areas Considering Uncertainties in Climate Projections
Authors: Cioffi Francesco , De Bonis Trapella Alessandro , Giannini Mario , Lall Upmanu
Published: May 2022

Coastal areas are particularly vulnerable to flooding from heavy rainfall, sea storm surge, or a combination of the two. Recent studies project higher intensity and frequency of heavy rains, and progressive sea level rise continuing over the next decades. Pre-emptive and optimal flood defense policies that adaptively address climate change are needed. However, future climate projections have significant uncertainty due to multiple factors: (a) future CO2 emission scenarios; (b) uncertainties in climate modelling; (c) discount factor changes due to market fluctuations; (d) uncertain migration and population growth dynamics. Here, a methodology is proposed to identify the optimal design and timing of flood defense structures in which uncertainties in 21st century climate projections are explicitly considered probabilistically. A multi-objective optimization model is developed to minimize both the cost of the flood defence infrastructure system and the flooding hydraulic risk expressed by Expected Annual Damage (EAD). The decision variables of the multi-objective optimization problem are the size of defence system and the timing of implementation. The model accounts for the joint probability density functions of extreme rainfall, storm surge and sea level rise, as well as the damages, which are determined dynamically by the defence system state considering the probability and consequences of system failure, using a water depth–damage curve related to the land use (Corine Land Cover); water depth due to flooding are calculated by hydraulic model. A new dominant sorting genetic algorithm (NSGAII) is used to solve the multi-objective problem optimization. A case study is presented for the Pontina Plain (Lazio Italy), a coastal region, originally a swamp reclaimed about a hundred years ago, that is rich in urban centers and farms. A set of optimal adaptation policies, quantifying size and timing of flood defence constructions for different climate scenarios and belonging to the Pareto curve obtained by the NSGAII are identified for such a case study to mitigate the risk of flooding and to aid decision makers.
Anxiety in Duckweed–Metabolism and Effect of Diazepam on Lemna minor
Authors: Lamaczová Adéla , Malina Tomáš , Maršálková Eliška , Odehnalová Klára , Opatřilová Radka , Přibilová Petra , Zezulka Štěpán , Maršálek Blahoslav
Published: May 2022

The fate of pharmaceuticals in the human body, from their absorption to excretion is well studied. However, medication often leaves the patient’s body in an unchanged or metabolised, yet still active, form. Diazepam and its metabolites, ranging up to 100 µg/L, have been detected in surface waters worldwide; therefore, the question of its influence on model aquatic plants, such as duckweed (Lemna minor), needs to be addressed. Lemna was cultivated in a Steinberg medium containing diazepam in three concentrations—0.2, 20, and 2000 µg/L. The activity of superoxide dismutase (SOD) and catalase (CAT), leaf count, mass, and the fluorescence quantum yield of photosynthesis were assessed. The medium was also analysed by LC-MS/MS to determine the concentration of diazepam metabolites. Our results show no negative impact of diazepam on Lemna minor, even in concentrations significantly higher than those that are ecotoxicologically relevant. On the contrary, the influence of diazepam on Lemna suggests growth stimulation and a similarity to the effect diazepam has on the human body. The comparison to the human body may be accurate because γ-Aminobutyric acid-like (GABA-like) receptors responsible for the effect in humans have also been recently described in plants. Therefore, our results can open an interesting scientific area, indicating that GABA receptors and interference with benzodiazepines are evolutionarily much older than previously anticipated. This could help to answer more questions related to the reaction of aquatic organisms to micropollutants such as psychopharmaceuticals.
Response of Domestic Water in Beijing to Climate Change
Authors: Wu Hao , Long Buju , Pan Zhihua , Lun Fei , Song Yu , Wang Jialin , Zhang Zhenzhen , Gu Hongyu , Men Jingyu
Published: May 2022

Beijing, a megacity in northern China, has been long facing the challenge of water scarcity, and the problem of domestic water scarcity has been becoming more serious in recent years due to climate change and global warming. To cope with the adverse effects of climate change, it is urgent to build a prediction model for water consumption in Beijing under the background of climate change. Here, a climate domestic water use model was established based on the historical meteorological data and domestic water use data, and the future domestic water demand in Beijing and the response of domestic water use to climate change were projected. The results showed that the climatic water consumption in Beijing will increase with climate warming by 177.23 million m3/°C, and the per capita annual water consumption will increase by 8.1 m3/°C. Combined with the CMIP6 multi-model climate change scenario data, the climate domestic water consumption in Beijing in 2035 under the four scenarios of SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5 will be 169 million m3, 189 million m3, 208 million m3, and 235 million m3 respectively; by 2050, the climate domestic water consumption in Beijing will reach 338 million m3, 382 million m3, 395 million m3, and 398 million m3, respectively. Under SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5 scenarios, if all the increased climate domestic water consumptions are supplemented by groundwater, compared with 2019, the groundwater depth will decrease by 0.18 m, 0.22 m, 0.27 m, and 0.32 m in 2035, respectively, and the area of funnel area will increase by 6.84 km2, 8.48 km2, 10.11 km2, 12.34 km2 respectively. Compared with 2035, the groundwater depth in 2050 will decrease by 0.37 m, 0.43 m, 0.41 m and 0.36 m, respectively, the area of funnel area will increase by 14.13 km2, 16.21 km2, 15.61 km2, and 13.68 km2, respectively. If the increased climatic water consumption in Beijing is supplemented by external water transfer, the cost of external water transfer in 2035 will increase by CNY 391 million, CNY 485 million, CNY 578 million, and CNY 706 million, respectively, compared with that in 2019 under the four scenarios. Compared with 2035, the cost of external water transfer in 2050 will increase by CNY 808 million, CNY 927 million, CNY 893 million, and CNY 783 million, respectively.
Antisemitism in the American Religious Landscape: The Present Twenty-First Century Moment
Authors: Jacobs Steven Leonard
Published: May 2022

This contribution is an examination of so-called “religious antisemitism” vis-à-vis the various Christian religious communities and/or denominations at the present time, framed by the recognition that, over the last several years, an increase in antisemitism in the United States has been shown by figures compiled by both the Federal Bureau of Investigation (FBI) and the Anti-Defamation League (ADL). It is further framed by examining the 2015 Pew Research Center Report “America’s Changing Religious Landscape,” and its 2016 “If the U.S. had 100 people: Charting America’s Religious Affiliations.”
RELACIONES FENOTÍPICAS Y HETEROSIS ENTRE HÍBRIDOS COMERCIALES Y GERMOPLASMA EXÓTICO DE MAÍZ EN JALISCO, MÉXICO
Authors: Morales-Rivera Moisés Martín , Ron-Parra José , Sánchez-González José de Jesús , Ramírez-Díaz José Luis , De la Cruz-Larios Lino , Mena-Munguía Salvador , Hurtado-de la Peña Salvador , Chuela-Bonaparte Margarito
Published: May 2022

En los programas de mejoramiento genético de maíz (Zea mays L.) de la región centro-occidente de México se han utilizado materiales genéticos adaptados, principalmente híbridos comerciales, poblaciones mejoradas y materiales exóticos provenientes de otras áreas. En este estudio se midieron las relaciones fenotípicas y genéticas entre poblaciones de maíz adaptadas y exóticas, para definir su mejor aprovechamiento genético, mediante técnicas de análisis multivariado (gráficas Biplot) y análisis de agrupamiento de materiales adaptados, exóticos y sus cruzas con caracteres agronómicos y componentes del rendimiento de mazorca. Se confirmó que el rendimiento de grano sigue siendo la variable más importante en la caracterización de materiales genéticos, en combinación con calidad de mazorca, acame y variables descriptivas del ciclo de madurez (floración masculina y femenina). Las técnicas de agrupamiento separaron con claridad los materiales adaptados de los exóticos, con excepción de las cruzas entre exóticos de más alto rendimiento (‘Pob49 x P-3394’ y ‘Pob32 x P-3394’), las cruzas que involucraron materiales exóticos con germoplasma tropicalsubtropical en su genealogía (‘Pob32 x SynB73’ y ‘Pob49 x Pob32’), y las cruzas que posiblemente involucraron materiales templados en su obtención (‘A-7573 x P3066’). En las cruzas de adaptados x exóticos, las combinaciones con ‘SynB73’ y ‘P-3394’ se ubicaron en el grupo opuesto al de las cruzas con ‘SynMo17 y ‘Blanco de Ocho’, y en el grupo intermedio predominaron cruzas con ‘Pob49’ y ‘Pob32’.
Control del dolor en el postoperatorio inmediato del servicio en servicio de cirugía
Authors: Chávez-Coronado Catherine Dayenara , Guamushig-Jaque Katheryn Mishel , Montesdeoca-Abad Génesis Vanesa , Gómez-Martínez Nairovys
Published: May 2022

Objetivo: Analizar el control del dolor en el postoperatorio inmediato del servicio en servicio de cirugía en el servicio de cirugía del Hospital Docente Ambato – Ecuador. Método: Descriptiva observacional en 99 pacientes quirúrgicos. Resultados: 52% de pacientes intervenidos quirúrgicamente se les diagnóstico una apendicitis aguda, seguido por la litiasis vesicular como patología quirúrgica con un 37, 4 % de representatividad. Conclusión: Para el bienestar del paciente es necesario el uso de medidas analgésicas frente a la consecuencia del acto quirúrgico, que es el dolor, se obtienen resultados positivos mediante la administración de medicación intravenosa (IV), manejo ambiental: confort y la vigilancia usando estas como las medidas base en el control de estos pacientes.
Enfermedad de Albers Schomberg (osteopetrosis). Reporte de un caso
Authors: Sacón-Espinoza Melanie Raquel , Gallegos-Cobo Andrés Eduardo
Published: May 2022

Objetivo: Describir la enfermedad de Albers Schomberg (osteopetrosis) desde un reporte de un caso. Método: Descriptiva observacional de caso clínico. Resultados y conclusiones: Por lo general, los niños son diagnosticados inmediatamente o poco después del nacimiento; se caracteriza por problemas hematológicos como anemia, trombocitopenia y granulocitopenia; esplenomegalia; la compresión de los nervios craneales que produce ceguera y sordera; fracturas patológicas e infecciones. Esta enfermedad es genéticamente recesiva existiendo hay falla de la médula ósea. A pesar del tratamiento, las formas infantiles o malignas siguen siendo las más graves por la anemia, las hemorragias y las infecciones complicadas, suelen provocar la muerte en los primeros diez años de vida. Por el contrario, los pacientes adultos tienen una tasa de supervivencia más alta.
Paciente masculino con síndrome antifosfolipídico con compromiso cardiopulmonar y renal. Caso clínico
Authors: Córdova-Molina Eduardo Fabián , Gordillo-Arias Ángel Daniel , Bonifaz-Díaz Diego Raúl
Published: May 2022

Objetivo: Analizar el caso clínico de un paciente masculino con síndrome antifosfolipídico con compromiso cardiovascular y renal en el Hospital Regional docente Ambato, detallando factores que provocaron en el paciente el desarrollo de complicaciones y las medidas a tomar para establecer un diagnóstico adecuado y el tratamiento integral. Método: Análisis del caso clínico del paciente masculino de 28 años de edad. Resultados y conclusiones: En el caso clínico expuesto; el estado de hipercoagulabilidad del paciente causó patologías tromboembólicas en diferentes niveles de aparatos y sistemas; estos fueron: trombosis pulmonar aguda que se complicó al presentar el paciente una NAC, trombos en la aurícula derecha, hipertensión pulmonar y trombocitopenia. Los criterios clásicos que deben estar presentes en el síndrome antifosfolípido son: presencia de anticuerpos anticardiolipina o anticoagulante lúpico, las complicaciones trombóticas, y si la paciente es de sexo femenino se incluyen un criterio extra que son los abortos espontáneos.
Preservativos en población sexual activa
Authors: Zapata-Panchi Luis , Pozo-López Ariana , Prado-Quilambaqui Jhofre
Published: May 2022

Objetivo: Describir el uso de preservativos en población sexual activa. Método: Descriptivo documental con análisis bibliográfico de 15 documentos relacionados al tema, los cuales fueron tomados de la base de datos PubMed. Resultados: Es posible considerar que tener una vida sexual activa sea incorrecto, pero solo un mínimo de participantes siempre ha utilizado preservativos a lo largo de su vida por lo cual se considera que esta muestra de población no lleva una vida sexual responsable, pero hay que tomar en cuenta también que usan otros métodos anticonceptivos. Conclusión: La sociedad ha ido disminuyendo los estigmas de la adquisición de preservativos, pero también se recalca que cierta parte de la muestra manifestó que aún se sentían juzgados por su familia o por la persona que comercializa preservativos.
Escáneres intraorales vs impresiones convencionales para diagnóstico y tratamiento odontológico
Authors: Morales-Núñez María Daniela , Moreano-Moreano Richard Omar , Salame-Ortiz Verónica Alejandra
Published: May 2022

Objetivo: Comparar métodos e identificar las ventajas y desventajas del flujo digital. Método: De tipo bibliográfica documental, mediante una búsqueda de artículos en bases de datos como: PubMed. Resultados: Fueron seleccionados 27 ya que contenían la información necesaria para cumplir con el objetivo principal de esta revisión. Conclusión: la toma de impresión todavía se considera que es incómodo para el paciente provocando en muchos desde nauseas hasta dificultad para respirar y atragantamientos, creando malas experiencias que generan desconfianza en el paciente cuando se encuentra en el ambiente odontológico, mientras que el escáner generalmente no origina este tipo de problemas.
Técnica ortoradial para la localización de conductos en endodoncia
Authors: Quiroz-Molina Jonathan José , Rojas-Uribe Tiana Mayerlin , García-Rodríguez Beatriz
Published: May 2022

Objetivo: Se evalúa la eficacia de las técnicas paralela y ortoradial en la visualización de conductos radiculares y la ocurrencia de distorsión de imagen en su aplicación, para contribuir a su conocimiento y aplicación en el área odontológica de Uniandes y de esa manera beneficiar la atención a los pacientes y al uso adecuado de los materiales odontológicos. Método: Estudio observacional, descriptivo y transversal. Resultados: con la técnica paralela se visualizaron conductos mesiolinguales en el 31,3% y la técnica ortoradial facilitó visualizar conductos mesiolinguales en el 93,7 % de pacientes y distolinguales en el 12,5% de personas. Conclusión: La técnica ortoradial es eficaz al momento de localizar los conductos radiculares que se encuentran en palatino o lingual de primeros premolares superiores y primeros molares inferiores, ya que con esta técnica se logra una disociación de raíces.
Manifestaciones orales de la infección por COVID-19
Authors: López-López Ximena Alexandra , Pilla-Pazmiño Kevin Ariel , Mestanza-Betancourth Diana Carolina , Salame-Ortiz Verónica Alejandra
Published: May 2022

Objetivo: Analizar las manifestaciones orales de la infección por covid-19. Método: Se realizó una revisión en PubMed y Scielo. Resultados: Fueron seleccionados 15 artículos después de la eliminación de literatura incompleta y artículos de opinión. Conclusión: En la práctica odontológica el peligro de contagiarse de SARS-CoV-2 es muy alto, debido a la proximidad con la cavidad bucal y la nariz del paciente. Las principales manifestaciones en cavidad oral asociadas a COVID-19 son: alteraciones AG y AO, trastornos de las glándulas salivales, infecciones oportunistas, lesiones vesiculares y vasculares, entre otras. Según la revisión de varios artículos, señalan que los tejidos orales son susceptibles principalmente en el tracto respiratorio, mucosa oral, lengua y glándulas salivales.
Revisión sistemática del uso de fibrina rica en plaquetas para el tratamiento de recesión gingival
Authors: Guerrero-Villacís Paola Nicole , Santamaría-Morales Renato Sebastián , Salinas-Goodier Carmen
Published: May 2022

Objetivo: Analizar el tratamiento de recesión gingival, mediante el uso de fibrinas rica en plaquetas FRP como coadyuvante del injerto de tejido conectivo, por medio de la comparación de artículos científicos. Método: Búsqueda bibliográfica en la base de datos PubMed y Scielo. Resultados: Los estudios han evidenciado que la Fibrina rica en Plaquetas tiene potencial para reducir síntomas postoperatorios y acelerar la curación a través de la estimulación de angio-génesis y biosíntesis de matrices. Gracias a su potencial regenerativo, las membranas PRF son una alternativa prometedora a la autogestión de injertos gingivales, con resultados alentadores en los casos de cobertura radicular. Conclusión: El uso de Fibrina rica en plaquetas en odontología se ha vuelto popular y ha sido utilizado para tratar la recesión gingival debido a su potencial para mejorar la cicatrización de herida liberando un gran número de factores de crecimiento y citocinas plaquetarias.
Kelor Leaves Infusion as a Alternative in Increasing the Volume of Breastmilk and Birth Weight in Newborn
Authors: Anuhgera Diah Evawanna , Ritonga Nikmah Jalilah , Sitorus Riris
Published: May 2022

Background: An increase in the volume of breast milk and baby weight is the hope of every mother during breastfeeding. The consistency and quality of breastfeeding is determined by a mother. Moringa leaves, which is a typical plant in Indonesia, have many benefits, especially to increase milk production and nutrition for infants and children in the growth process. The purpose of this study was to determine the effect of morinaga leaves in increasing the volume of  breast milk and birth weigh of babies.

Method:The design of this study was quasy eksperimental studies with purposive sampling with inclusion criteria. The sample in this study were all breastfeeding mothers on the first postpartum day as many as 30 people. In this study there were two groups, namely the control group and the intervention group. The instruments in this study were Moringa leaves, measuring cups, electric breast pumps, and baby scales and observation sheets. Data analysis used is paired and unpaired t-test.

Result:The results showed that there was a difference between before and after the administration of Moringa leaves in the intervention group of 38.95 ml, while in the control group it was 16.1 ml. The baby's weight gain in the intervention group was 585 grams. Statistical results showed that giving Moringa leaves was effective on breast milk volume and infant weight with a significance value of p = 0.00 while in the control group there was a difference in the increase in breast milk volume with p = 0.000 but there was no significant difference in the baby weight variable with a value of p = 0.651.

Conclusion: Moringa leaves infusion can be used as an alternative therapy to increase the volume of breast milk and baby weight in the breastfeeding process. Specialized health workers for midwives can assist mothers in educating postpartum mothers in consuming steeped Moringa leaves to increase breast milk and baby weight and support the success of exclusive breastfeeding
Risk Factors For Malaria Incidence In Pregnant Women In Puskemas Bosnik And Marau Regency Biak Numfor
Authors: Manik Inggrit Rita Uli , Rumansara Ritha , . Ruslan
Published: May 2022

Malaria infection in pregnancy is very detrimental to both the mother and the fetus it contains, because it can increase the morbidity and mortality of the mother and fetus. The prevalence of malaria in Papua Province with Annual Parasite Incendence in 2016 amounted to 208.95 per thousand population, the prevalence of malaria in pregnant women in Papua Province as much as (3.09%). The prevalence of malaria in pregnant women in Biak Numfor Regency in 2017 was 4.11%. The purpose of this study was to determine the risk factors for the incidence of malaria in pregnant women at the Bosnik and Marau Health Centers, Biak Numfor Regency in 2018.This study is an observational study with case control design in pregnant women in the Bosnik Health Center and Marauw Health Center area of Biak Numfor Regency. The study sample with simple random sampling was 27 pregnant women as cases and 27 pregnant women as control.data analised with chi square test. From the results of a multivariate analysis found 2 (two) variables associated with malaria incidence in pregnant women, namely sleeping not using mosquito nets (OR = 3,768 p = 0.024 95% CI 1,158-12,270) and Hb anemia < 9 gr% (OR = 5,500 p = 0.013 95% CI 1,323-22,862) while 3 (three) variables namely low economic status, first parity and ≥ 4 and nutritional status is not associated with malaria incidence. Risk factors for malaria incidence in pregnant women are related to sleep habits not using mosquito nets and anemia Hb < 9gr%.
Midwives On The Frontline: History Of Exposure To Covid-19 And Relationship With Anxiety
Authors: Nurrasyidah Rahmi , Sari Lutfiana Puspita
Published: May 2022

Midwives have a high risk of being infected COVID-19 because they have a heavy workload. Midwives who work in health services also have families to protect. The threat of being exposed to COVID-19 can affect their psychological state include anxiety. This study aims to determine the relationship between a history of exposure to COVID-19 in midwives and their families with the midwife's anxiety about COVID-19. This is a cross sectional study design. Sample involved in this study was 135 midwives working in Klaten Regency. The instrument uses a questionnaire. Results of the study found that there was no significant relationship between midwife's and family's history of being exposed to COVID-19 and the midwife's anxiety about COVID-19 (p value > 0.005). It is necessary to improve the design with case controls in future studies.
Relationship Between Patient Perceptions Of The Quality Of Inpatient Registration Services And Satisfaction Of Inpatients
Authors: Octavariny Raisha , Simarmata Marice
Published: May 2022

The hospital, as a referral level health service institution has the task of providing complete individual health services which include promotive, preventive, curative, and rehabilitative. Hospitals must meet the completeness of professional human resources, superior facilities where all of these indicators can affect service delivery to provide satisfaction to patients. This study aims to determine the relationship between patient perceptions of the quality of inpatient registration services and satisfaction of inpatients at GrandMed Hospital inpatient room, using an analytical survey research type. The sample of this study were 30 patients in the Ns 3D room using a questionnaire instrument. The sampling technique used is total sampling using the chi square test with a 95% confidence level = (0.05). The results showed that there was a relationship between inpatients’ perceptions of the quality of inpatient registration services based on responsiveness (P= 0.049 < (0.05) and empathy (P= 0.000 < (0.05) with inpatient satisfaction at Ns 3D GrandMed Hospital Lubuk Pakam. There is no relationship between inpatients’ perceptions about the quality of inpatient registration services based on tangible (P= 0.414 > (0.05), reliability (P= 0.283 > (0.005) and assurance (P= 0.783 > (0.05) with satisfaction of inpatients at Ns 3D Hospital GrandMed Lubuk Pakam. The results of this study are expected to be taken into consideration to improve the quality of services in the inpatient registration room at GrandMed Hospital.
Relationship Of Nursing Services With Patient Satisfaction BPJS Inspired
Authors: Girsang Desri Meriahta , Wahyudi Agung
Published: May 2022

Based on the Law of the Republic of Indonesia No. 36 of 2014, Health Service is any effort or activity that is carried out in an integrated, integrated and sustainable manner to maintain and improve the health status of the community in the form of disease prevention, health improvement, disease treatment, and health restoration by the government and or the community. Health services are a sub-system of health services whose main purpose is preventive (prevention) and promotive (health improvement) services with community targets. This type of research is a quantitative research that is an analytic survey with a cross sectional design which aims to determine the relationship between nursing services and BPJS patient satisfaction inpatients at Grandmed Lubuk Pakam Hospital which was observed at the same time. The population of this study were all outpatients, determined using a total sampling of 35 people. The data were processed using the chi square test at a 95% confidence level (α = 5%). The results of this study indicate that there is no relationship between nursing service on tangible dimensions (0.321> 05), empathy (0.130> 0.05), and responsiveness (0.526> 0.05), while reliability (0.652> 0.05). assurance (0.530>0.50)). With patient satisfactio bpjs patient satisfaction is inpatient at grandmed Lubuk Pakam hospital. The conclusion in this study is that there is no relationship between nursing service end satisfaction of inpatient BPJS Patients at grandmed Lubuk Pakam hospital.
Relationship Of Health Service Quality With Bpjs Patient Satisfaction In The Outpatient Unit Lubuk Pakam Grandmed Hospital
Authors: Sirait Reni Aprinawaty , Simatupang Silvia Indriani
Published: May 2022

The quality of health services reflects the improvement of health services in achieving patient satisfaction. Increased public awareness will encourage the demand for health services. These issues and some of the outstanding cases have created a public perception that there is a disparity in services for BPJS patients in general. The purpose of this study was to determine the relationship between the quality of health services with patient satisfaction BPJS card users at Grandmed Hospital. This type of research is an interpretive survey using a cross sectional approach. The sampling technique used is random sampling, which applies certain considerations in sampling. Service quality is a measure of how well the services provided meet customer (patient) expectations. In this study, a cross-sectional approach was used for analysis and investigation. The sample in this study were inpatients at Grandmed Lubuk Pakam Hospital with 32 respondents using the accidental sampling method using the chi square test using a 95% confidence level = (0.05). The results showed that there was still a significant relationship between services using grade 1 inpatient satisfaction where tangible p (0.038) < (0.05), reliability p (0.003) < (0.05), responsiveness p (0.026) < (0 ,05). ), guarantee p (0.002) <α (0.05) and feel p (0.005) <α (0.05). It is hoped that health workers will improve the quality of services provided, especially outpatient BPJS patients, apply smiles, greetings, speed, service schedules & punctuality in patient examinations so as to create interaction between patients and nurses. For hospital management, it is necessary to develop a information management system to facilitate services & matters of housing needs quickly.
The Relationship of Psychological Stress With Breast Milk Production to Breastfeeding Mothers Post Delivery in the Clinic Wulandari Medan in 2021
Authors: Ginting Desideria Yosepha , Tarigan Layari , Handayani Dwi , Sitio Lasima Hotma
Published: May 2022

Postpartum mothers are mothers in the postnatal period, postpartum mothers often experience psychological stress which usually occurs in the first week to the sixth week after delivery. Mother's psychological stress usually occurs due to hormonal factors, family support, new roles, busy taking care of babies and lack of knowledge. Breast milk is a very important source of nutrition to meet the needs of babies, one of the factors that affect breast milk production is psychological stress. The purpose of this study was to identify the relationship between psychological stress and breast milk production in postpartum breastfeeding mothers at the Wulandari Clinic, Medan. This type of research is quantitative research with a correlation research design with a cross-sectional approach. The sampling technique in this study was total sampling with 38 respondents. The measuring instrument in this study used a questionnaire sheet. Data analysis was performed using the chi-square test. The result of this study is that the p-value of 0.000 is smaller than a significant value of 0.05, so there is a relationship between psychological stress and milk production in breastfeeding mothers after childbirth at the Wulandari Clinic, Medan in 2021.
Effect of Combination of Murottal Therapy And Relaxation of Deep on Hypertension in Trimester II Pregnant Women
Authors: Ulya Fitria Hikmatul , Sari Novita , Eta Siti Rohyati
Published: May 2022

Latar Belakang: Hipertensi dalam kehamilan merupakan 5-15% penyulit kehamilan dan merupakan salah satu dari tiga penyebab tertinggi mortalitas dan morbiditas ibu hamil terutama di negara berkembang. Tujuan Penelitian: Mengetahui pengaruh kombinasi terapi murotal dan relaksasi  nafas dalam terhadap hipertensi pada ibu hamil trimester II. Metode penelitian: jenis penelitian ini adalah Quasi Experiment dengan Pre and Post Test Design, teknik pengambilan sampel purposive random sampling dengan sampel 18 hamil trimester II di wilayah kerja Puskesmas Warureja, Alat penelitian menggunakan lembar observasi, SOP pterapi murotal, SOP relaksasi nafas dalam, tensi meter, smartphone, headphone. Analisis yang digunakan yaitu uji wilcoxon. Hasil Penelitian: didapatkan median tekanan darah sistolik responden sebelum dilakukan kombinasi terapi murotal dan relaksasi nafas dalam sebesar 140 mmHg dan diastolik sebesar 100 mmHg sedangkan sesudah intervensi didapatkan nilai median sebesar 130 mmHg dan diastolik sebesar 80 mmHg. Hasil uji Wilcoxon di peroleh nilai p value 0,000 (sistolik) dan 0,001 (diastolik) atau (p<0,05). Kesimpulan: Ada pengharuh kombinasi terapi murotal dan relaksasi nafas dalam terhadap hipertensi pada ibu hamil trimester II di Puskesmas Warureja Kabupaten Tegal.
Large surface acoustic wave nonreciprocity in synthetic antiferromagnets
Authors: Matsumoto Hiroki , Kawada Takuya , Ishibashi Mio , Kawaguchi Masashi , Hayashi Masamitsu
Published: May 2022

We have studied the transmission of surface acoustic waves (SAWs) in ferromagnetic/non-magnetic/ferromagnetic tryilayers. The SAW scattering matrix is studied for devices with various non-magnetic spacer thickness, which defines the strength of the interlayer exchange coupling. We find the SAW transmission amplitude depends on its propagation direction when the two ferromagnetic layers are coupled antiferromagnetically. The degree of such SAW nonreciprocity increases with increasing exchange coupling strength and reaches 37 dB mm−1 for a device with the thinnest spacer layer. These results show the potential of interlayer exchange coupled synthetic antiferromagnets for viable acoustic nonreciprocal transmission devices, such as circulators and isolators.