bluuebunny/crossref_metadata_2025 huggingface dataset:
FUNCTIONAL RECOVERY IN PATIENTS WITH ACUTE ISCHEMIC STROKE AND ITS DEPENDENCE ON THE BLOOD PRESSURE VARIABILITY
Authors: Cherenko T. M. , Heletyuk Yu.L.
Published: April 2024

Objective  - to investigate the association between functional recovery in patients with acute ischemic stroke and arterial hypertension, daily blood pressure (BP) monitoring and its variability.

Materials and methods. One hundred fifty patients with initial ischemic stroke and history of arterial hypertension have been examined: 74 (49.3%) women and 76 (50.7%) men with mean age of 67.4±0.7 years. Neurological deficit was evaluated by NIHSS scale, functional outcome – by Barthel index. The diagnosis of hypertension was based on the results of clinical, instrumental examination and medical documentation. Blood pressure daily monitoring was applied from the admission and every 4 hours during 6 days of acute stroke period. We studied mean values of SBP, DBP, maximum values of SBP and DBP, the variability of blood pressure (SD), counted for SBP and DBP. Statistical analysis of the results was performed using the statistical analysis IBM SPSS Statistics Base v.22.

Results. The degree of functional recovery in patients with history of hypertension in the acute stroke period significantly correlated with the severity of hypertension (r=0.351), its duration (r=0.426) and degree of neurological deficiency at discharge: r=0.739, p=0.001.

The most significant association between the parameters of daily blood pressure monitoring and functional dependence at the end of an acute period was established: between SD SBP and the Barthel index for 1 day, 1-3 days and 1-6 days: r =-0427, r =-0.551 and r =-0.515, respectively; SD DBP significantly correlated only in the interval from 1 to 3 days (r=0,550). Single-factor regression analysis has found the association between the functional defect degree in patientswith acute stroke at discharge and systolic blood pressure variability over a period of 1-3 days, R2 = 0.304.

Conclusions. The effectiveness of functional recovery depends on the systolic blood pressure variability over a period of 1-3 days after stroke.
LIMBS REAMPUTATIONS IN MILITARY PERSONNEL INJURED IN THE AREA OF THE ANTITERRORIST OPERATION IN EAST UKRAINE
Authors: Bespalenko А.А. , Buryanov А.А. , Tsema Ie.V. , Dinets A.V.
Published: April 2024

The aim – to identify and analyze causes for reamputations in military personnel with limb amputations due to ATO in East Ukraine. Patients and methods. All military personnel of the AFU within ATO was eligible for the study with diagnosis of limb amputations in the period from 01.06.2014 to 30.06.2016, and which were treated in hospitals of the Ministry of Defense of Ukraine. Among 7091 patients with injuries, 152 patients with limb amputations were identified.

Results and discussion. Out of 152 patients, 25 (16%) underwent limbs reamputation, whereas 127 (84%) patients underwent amputation once. Patients in the study groups did not differ in age. Amputation was performed on the upper limb in 41 (32%) in the group of patients with amputations, which is significantly higher as compared to 2 (8%) patients in the reamputation group (p = 0.014). Analyses the level of amputations of the upper extremity showed no difference in the parameters. In 23 (92%) patients in the group with reamputation amputation of the lower limbs were diagnosed significantly more often as compared to 86 (68%) patients in the amputation group (p = 0.014). Analyses of the level of amputation of the lower extremity revealed that almost 3 times more often amputation was performed at the level of the ankle in the group of patients with reputations - 8 (32%) patients, as compared to 15 (12%) patients in the amputation group (p = 0.03). However, linear regression did not show a significant difference of these parameters in reamputations. Amputation of one upper extremity in the reamputation group was diagnosed 7 times less frequent - 1(4%) patient less often than in the amputation group - 37(29%) patients (p = 0.005).

Conclusions: The results of the study of the injured in a hybrid war indicate that reamputations are more often associated with amputations at the level of the upper limb, but are less often diagnosed in patients with amputation of the lower extremity. Reamputations are more often performed with trauma of one limb. Clinical features in patients injured in the ATO zone in the East Ukraine demonstrate the frequency and characteristics of re-arrests that are different from other armed conflicts.
АМБУЛАТОРНИЙ ЕТАП КАРДІОЛОГІЧНОЇ РЕАБІЛІТАЦІЯ ХВОРИХ ПІСЛЯ РЕВАСКУЛЯРИЗАЦІЇ КОРОНАРНИХ СУДИН, ПРОБЛЕМИ ТА ПЕРСПЕКТИВИ
Authors: Ovdii M.A.
Published: April 2024

За даними Всесвітньої організації охорони здо- ров’я (ВООЗ) у наш час на долю серцево-судинних захворювань (ССЗ) припадає близько 31% смерті в усьому світі. Від ССЗ у 2012 році померло 17,5 мільйона чоловік, серед них 7,4 мільйона чоловік померли від ішемічної хвороби серця (ІХС). За даними American Heart Association, в США на ІХС страждає понад 5 мли. осіб. ІХС є головною причиною смерті для чоловіків у віці до 3 5 років, а у віці після 45 років головна причина смерті як для чоловіків, так і для жінок. В Англії щорічно близько 30% чоловіків та 22% жінок помирають від ІХС [1].В Україні смертність від ССЗ є однією з найвищих у світі та становить 66,6% у загальній структурі смертності. Поширеність ІХС в Україні серед осіб працездатного віку у 2013 році становила 9,7 тис. на 100 тис. населення, поширеність ІХС серед осіб дорослого віку у 2013 році в Україні становила 24 тис. на 100 тис. населення [2]. В усьому світі та Україні для лікування ІХС застосовують хірургічні методи такі як аорто-коронарно- го шунтування (АКШ) та черезшкірне коронарне втручання (ЧКВ) [3]. Але не дивлячись на широке застосування новітніх медикаментозних та прогресивних хірургічних методів лікування ІХС експерти ВООЗ прогнозують, що у 2020 році від ССЗ можуть померти 22 мільйона осіб. Ряд літературних джерел [4-7] вказує на важливе значення своєчасного застосування кардіологічної реабілітації на всіх її етапах особливо у хворих після оперативного лікування ІХС. Метааналіз рандомізованих контрольованих досліджень показав, що застосування кардіологічної реабілітації призводить до зниження смертності від ССЗ та смертності від інших причин на 26-31% та 15-28% відповідно [8]. American Heart Association, визначає кардіологічну реабілітацію, як перший клас, рівень А рекомендацій [6]. Попри всі переваги, які надає кардіологічна реабілітація, в своїх роботах [9,10] ряд науковців наголошують на тому, що вона все ще знаходиться у тіні хірургічного та медикаментозного лікування. В світі, тільки 38,8% країн мають кардіологічні програми реабілітації, зокрема, серед них 68,0% країни з високим рівнем доходу, 28,2% країн із середнім рівнем доходу та 8,3% з низьким рівнем доходу [11]. Данні стосовно проходження кардіологічної реабілітації хворих після хірургічного лікування ІХС в України відсутні, тому дослідження даного питання є актуальним.
ЗНАЧЕННЯ РЕЗУЛЬТАТІВ ДОСЛІДЖЕННЯ ПСИХО-АКУСТИЧНИМИ МЕТОДАМИ У ВЗАЄМОЗВ’ЯЗКУ З ЕЛЕКТРОФІЗІОЛОГІЧНИМИ ПРИ ЛІКУВАННІ ХВОРИХ З ПОЧАТКОВОЮ СЕНСОНЕВРАЛЬНОЮ ПРИГЛУХУВАТІСТЮ СУДИННОГО ҐЕНЕЗУ
Authors: Shidlovsky A.Yu.
Published: April 2024

Наведені результати обстеження і лікування 93 хворих з починається сенсоневральної приглухуватістю судинного ґенезу. Показана важливість комплексного обстеження зазначених хворих із застосуванням психоакустических методів у взаємозв’язку з електрофізіологічними (реоенцефалографія, електро- енцефалографія, коротко-латентні і довго-латентні слухові потенціали) як для поліпшення топічної діагностики, так і ефективності лікування таких хворих.

Мета роботи - проаналізувати результати дослідження психоакустичними методами у взаємозв’язку з електрофізіологічними (реоенцефалографія, електроенцефалографія, коротко-латентні і довго-латентні слухові потенціали) у хворих з початковою сенсоневральної приглухуватістю судинного ґенезу і провести їм лікування з урахуванням виявлених змін, а також судинного фактора, який її супроводжує, що сприятиме поліпшенню якості їх топічної діагностики та ефективності лікування.

Використання результатів сучасних психоакустических методів дослідження у взаємозв’язку з електрофізіологічними: дослідження слуху в розширеному діапазоні частот, реєстрація коротко- і довго-латентних слухових викликаних потенціалів реоенцефалографія і електроенцефалографія, при дослідженні хворих з сенсоневральної приглухуватістю на ранніх стадіях її розвитку підвищує якість їх діагностики та відкриває можливості розробки більш обґрунтованих комплексних і ефективних методів лікування і сенсоневральної приглухуватості.

Оцінка функціонального стану слухового аналізатора і головного мозку в цілому відповідно до цього коротко- і довго-латентних слухових викликаних потенціалів, електроенцефалографїї, а також мозкового кровообігу за даними реоенцефалографія, а при необхідності і ультразвукової доплерографїї судин голови та шиї є необхідними компонентами при лікуванні хворих ще з початкової сенсоневральної приглухуватістю судинного походження.

На основі отриманих результатів дана оцінка ефективності лікування хворих з початковою сенсоневральної приглухуватістю судинного ґенезу до і після лікування за даними не тільки суб’єктивних, а й об’єктивних методів дослідження.

Важливим є і те, що оцінки ефективності лікування хворих з наявністю сенсоневральної приглухуватості судинного ґенезу були вперше дано за даними не тільки суб’єктивною, але і об’єктивної аудіометрії.
ХАРАКТЕРИСТИКИ І ОБҐРУНТУВАННЯ ЗАСТОСУВАННЯ ПЕЛЕТ ЯК СУЧАСНОЇ ЛІКАРСЬКОЇ ФОРМИ НА РИНКУ УКРАЇНИ
Authors: Yerkhova Anna , Katynska Maryna
Published: April 2024

Анотація: в наш час, одним із розповсюджених на фармацевтичному ринку України лікарських засобів у

формі пелет є кишковорозчинні пелети омепразолу (Gorobets, Matyash, Pekhenko & Barna, 2019). Цей лікар-ський засіб доступний у вигляді капсул. Пелети – це мультипартикулярні лікарські форми, що мають ряд пе-реваг перед монопартикулярними лікарськими формами, тому пелети – це перспективні пероральні систе-ми доставки активного фармацевтичного інгредієнту (АФІ). Пелети використовують коли стабільність

діючої речовини при коливанні показників рН середовища змінюється, у випадку коли можливе подразненняслизової оболонки шлунку, для полегшення ковтання (особливо актуально для пацієнтів які страждаютьдисфагією, пацієнтів похилого віку та дітей). При використанні полімерів в оболонці можливе регулюваннявивільнення у певному відділі ШКТ, це дозволяє отримати точковий фармакологічний ефект. Крім цього,пелети можуть бути різного розміру (від 0,1 до 2 мм), завдяки своїй формі пелети проявляють стійкість

до стирання та більш плинні. Омепразол – це речовина синтетичного походження. Активний фармацев-тичний інгредієнт відповідає за пригнічення секреції шлункової кислоти. Відноситься до фармацевтичної

групи інгібіторів протонного насосу , препарати цієї групи призначають для лікування активних виразокдванадцятипалої кишки, шлункових виразок, гастро- езофагального рефлюксної хвороби (ГЕРХ), важкого

ерозивного езофагіту, патологічних гіперсекреторних станів, наприклад, синдром Золлінгера-Еллісона. Се-ред найчастіше використовуваних методів виробництва пелет вирізняють: поетапне розпилення розчинів

або суспензій (друга назва – поетапне нашарування); пряма пелетизація (друга назва – екструзія-сфероні-зація); розпилювальна сушка та розпилювання охолодження розплавів; алгомерація-сферонізація. На жаль,

станом на цей час жоден із українських виробників не займається виготовленням кишковорозчинних пелетсамостійно (закуповують вже готові пелети), при цьому на внутрішньому ринку присутні лікарські засобияк закордонного, так і українського виробництва. У статті присутній огляд фармацевтичних препаратів

в формі пелет, систематизація інформації щодо методів виробництва, огляд лікарських засобів омепразо-лу у формі пелет, що представлені на фармацевтичному ринку України. Метою цього дослідження було:

узагальнити випадки, коли використання такої форми як пелети є найбільш обґрунтованим; зробити оглядлікарських засобів в Україні, що містять пелети; узагальнити сучасні методи виробництва пелет.
MORPHOMETRIC FEATURES OF THE THYMUS STRUCTURE DUE TO THE INFLUENCE OF XENOBIOTICS
Authors: Shyian Denis , Avilova Olga
Published: April 2024

Nowadays scientific achievements in various areas of lives have caused the creation of more and more «foreign body substances» known as xenobiotics. Different chemicals have the detrimental effect on the body systems and, thus, all humanity. The purpose of this work is to determine the alterations of the white rats' organometric indexes of the thymus after xenobiotic induction in 1/10 and 1/100 LD50doses with the average lethal dose in 5,75 g/kg of the body. For the study was chosen commonly used polyether that belongs to a group of «Laproxides» - tryglycidyl ether of polyoxypropylene triol. The research presents a theoretical generalization of the experiment results and establishes the mechanism of action of this xenobiotic. Were used morphometric, mathematical and statistical methods. The morphometric investigation revealed the size reduction of the thymus after chemical induction on 7th, 15h, 3Cfh day with the high degree of authenticity that was proved by the changed morphometric parameters of the organ - weight, length, breadth, thickness. The analysis of the obtained results allows to state that this substance, in conditions of the oral administration to the body in the above mentioned doses, can lead to atrophy and thymus dysfunction
DIAGNOSTIC AND THERAPEUTIC VALUES OF AMINO ACID COMPOSITION OF BLOOD AND AMINO ACID INDICES AS MARKERS OF ARRHYTMIAS OF ISCHEAMIC GENESIS AND CARDIOVASCULAR RISK IN PATIENTS WITH STABLE ISCHEAMIC HEART DISEASE ON THE BACKGROUND OF DIABETES MELLITUS TYPE
Authors: Belikova J.
Published: April 2024

The purpose of the study was to determine the diagnostic value of the amino acid composition of blood (ACC) and its indices as markers of cardiac rhythm disturbances (СRD) and cardiovascular risk (CVR) in patients with stable coronary heart disease (CHD) in patients with type 2 diabetes mellitus (DM2) . Object and methods of investigation The data of examination of 51 patients with stable ischemic heart disease in the background of CD2 (30 men and 21 women, median ages -64, 2 years) and 22 patients with stable coronary heart disease without violations of carbohydrate metabolism were analyzed. 20 amino acids (AMC) and the relationships between them were determined, in which AMCs were combined by a competitive mechanism of transport into the cell. According to the results of holter ECG monitoring, patients with comorbid pathology were divided into 2 groups: with and without arrhythmias of ischemic genesis (AIG) of high grades.

Results The Tau / Ala and Fen + Tyr / Met indices have high specificity (Sp) and positive predictive value (PPV) (93.9 and 95.1 and 93.9 and 95.1, respectively) at low sensitivity (Se ) and negative predictive value (NPV). The Tau and BCCA indices showed low Sp and PPV at high Se and NPV (89.9 and 86.7 and 84.6 and 86.5, respectively). The statistically significant correlation between the ASA indices and the parameters characterizing lipid (LO) and carbohydrate metabolism (VO), SDP, and cardiovascular risk (SSR) on the SMART scale (SMART RISK) were found. 

Conclusions Since none of the specified indicators demonstrated simultaneously high specificity and sensitivity to AIG, and correlation relationships with lipid and carbohydrate metabolism and AIG did not show a high and moderate strength of communication in all parameters, the indices should be applied in accordance with the research stage: Tau and ARCs are most suitable for screening purposes, Tau / Ala and Phen + Tyr / Meth are more suitable for the purpose of therapy and as a control of treatment.
CONTENT OF MMP-9 IN SERUM, SALIVA, TISSUES IN PATIENTS WITH CYST OF THE MAXILLARY SINUS
Authors: Naumenko O. , Deeva J. , Rezmac M.
Published: April 2024

Department of Otorhinolaryngology Bogomolets National Medical University 125 patients with a cyst of the maxillary sinus were observed. The aim of the study was to determine the content of MMP-9 in the preoperative period in saliva, serum, in the shell of a cyst, which was removed from the maxillary sinus. The data obtained in our study indicate the relationship between such pathology as a cyst of the maxillary sinus and an increasing the level of MMP-9 in the saliva of the examined patients. Most patients who showed an increase of the content of MMP-9 in saliva also showed an increase of the level of MMP-9 in the cyst envelope. It can be assumed that the increase of MMP-9 in saliva is due precisely to the course of latent, asymptomatic periodontitis.
AMPUTATION OF EXTREMITIES DUE TO MODERN COMBAT OPERATIONS, CLINICAL ANATOMICAL ASPECT
Authors: Guriev S.O. , Lysun D.N. , Kushnir V.A. , Kurachenko І.P.
Published: April 2024

The article analyzes the clinical and anatomical aspect of amputations of the extremities in the victims of the antiterrorist operation in the east of Ukraine. Data analysis was conducted in accordance with the requirements and criteria of evidence-based medicine using computer technology. The scope and nature of the research suggests that the study has a cohort character with the level of evidence IIb, Oxford The purpose of the study. Determine the amount and need for amputations in modern combat with limb injuries. Based on a risk-oriented approach. Materials and methods. To perform the task of this study, we conducted a scientific analysis of 1072 victims, as a result of combat injuries of extremities of different genesis, by the random number method and the methodology of irretrievable randomization. Results. It was found that 62.22% of the lower extremity is injured, the upper extremity is 37.78%, the ratio is 1.6. In the structure of amputations, the thigh and shin are at the first ranked place – 29.31%, at the second stop – 15.52%, on the third – the brush – 13.79%, on the fourth forearm – 8.62% and the shoulder – 3, 45. Bilateral injuries of the lower limbs account for 65.22%, and upper limb injuries account for 34.78%.
LONG-TERM FUNCTIONAL AND HISTOLOGICAL OUTCOMES OF RAT’S SCIATIC NERVE RECOVERY AFTER SEVERE INJURY AND EXPERIMENTAL TREATMENT WITH SILICON MICROWIRES
Authors: Likhodiievskyi Volodymyr V. , Korsak Alina V. , Olefir Serhii S. , Zabila Anna O. , Bukovska Marya R. , Turiy Marya V. , Klimovska Alla I.
Published: April 2024

Severe peripheral nerve injuries both with traumatic limb amputations constitute a substantial part in all limb injuries especially during armed conflicts.

For nerve grafting, nerve fibers alignment and fabrication of mind-controlled prosthetic limbs the concept of regenerative nerve implants with peripheral nerve interfacing was proposed. 

Silicon showed ideal properties not only for microelictronic devices fabrication but also as a favorable growth medium for neurons in vitro.

This study aimed at evaluating the impact of silicon wires as a part of nerve conduit on motor and sensory recovery simultaneously with distal nerve stump neurotization using rat sciatic nerve injury model.

Materials and methods. We performed experiments on 33 male Wistar rats that were divided into the following groups: I – sham-operated, II – those which received right sciatic nerve transection with 10 mm gap formation with autoneurografting, III – with 10 mm nerve gap bridged by allogenic decelullarized aorta with 4% carboxymethylcellulose hydrogel, IV – with 10 mm gap bridged by allogenic decelullarized aorta with 4% carboxymethylcellulose hydrogel and aligned p-type boron-ligated silicon wires.

12 weeks after operation all rats were examined using von Fray filaments and by Walking track analysis method. For histological analysis right sciatic nerves were harvested. Frozen sections were stained with H&E and nitric silver impregnation was performed. At distal nerve stump nerve fibers density was calculated. The obtained results were compared using nonparametric statistical tests.

Results. The histological analysis revealed differences in tissue reaction patterns between rats from autoneurografting group and conduit grafting groups.

Histomorphometric data showed that nerve fibers density in rats from group IV was significantly higher than that in rats from group III (aorta+hydrogel grafting), but remained lower than in group II (autoneurografting).

Morphometric data were supported by functional tests data: rats from group IV demonstrated higher values of SFI than those in group III and same as those in group II.

Conclusions. According to histological and functional data we can presume that use of silicon wires as a part of hollow conduit improves results of injured sciatic nerve regeneration.
Análise ergonômica do trabalho em um município brasileiro no Pará
Authors: Inacio Alessandra do Nascimento Santana , Santos Aline Pereira , Oliveira Anaísa Duarte de , Ribeiro Jéssica da Silva , Silva Maria José Pereira da
Published: March 2024

Objetivo: Este estudo tem o objetivo de fazer uma análise ergonômica do trabalho (AET) de frentistas em um município do Pará, considerando o ambiente de trabalho do ponto de vista deles, disponibilizando aos mesmos a confiança para exercer a função. Metodologia: A ergonomia faz a adaptação do trabalho ao homem, fazendo perceptível os possíveis riscos ergonômicos com os trabalhadores, no caso da pesquisa que se explorou neste trabalho, faz-se menção os postos de combustíveis. Para consolidação da pesquisa utilizou-se uma abordagem com o método das pesquisas qualitativa e exploratória, sendo aplicados formulários com 10 colaboradores, de distintos postos da região, com perguntas semiestruturadas. Resultados: analisou-se frentistas de ambos os sexos, com idades entre 18 e 39 anos, analisando que no ambiente de trabalho não tem a visão o bem-estar do funcionário, com os gargalos em relação aos colaboradores, sendo que boa parte tinha excessivas cargas horárias de trabalho. Percebeu-se a falta de conhecimento sobre os possíveis riscos futuros ocasionados pela profissão, havendo também desvios de funções. Limitações da Pesquisa: o estudo não abrange todos os trabalhadores dos postos de combustíveis investigados. Originalidade: a falta do cumprimento da Norma Regulamentadora 17 é importante a aplicação de estudos similares em outras regiões.
Spatially Weighted Multinomial Modelling of Comorbidity of Anaemia and Malaria among Under-Five Children in Nigeria
Authors: Ibrahim Aminu , Adeyemi Rasheed A. , Usman Abubakar
Published: April 2024

Children in sub-Saharan African countries, especially Nigeria, continue to suffer increased mortality owing to comorbidity of infections such as anaemia and malaria, which are known to epidemiologically overlap. In order to examine the risk factors and spatial patterns of comorbidity of anaemia and malaria using the 2021 Nigeria Malaria Indicator Survey (NMIS), a multinomial logit model was extended by incorporating a spatially weighted random effect. The impact of climatic variation on the childhood disease comorbidity was explored by weighting the spatial structured component based on the 2021 NMIS average cluster temperature of each state in Nigeria. A number of spatially weighted geo-additive models were fitted and compared using deviance information criterion. Inference was fully Bayesian, and an Intrinsic Conditional Autoregressive prior was used for structured random effects. Based on the map generated from the best-fitted model, which unveiled states that are more susceptible to the risk of disease comorbidity, the average temperature used as a weighting factor, however, has a strong relationship with the spatial pattern of disease comorbidity. States with low temperatures have a higher risk of comorbidity of anaemia and malaria compared to states with higher average temperatures. Area of residence, level of education of the mother, economic status of the mother, and owning mosquito-treated nets were identified as the significant risk factors associated with the disease comorbidity. Findings from this study will be helpful to policymakers and health authorities in their effort to combat the comorbidity of childhood anaemia and malaria, thereby reducing child mortality in Nigeria.
Impacts of basis sets, solvent models, and NMR methods on the accuracy of 1H and 13C chemical shift calculations for biaryls: a DFT study
Authors:   Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam, Nguyen Thien ,   Faculty of Natural Science, Duy Tan University, Da Nang 550000, Vietnam
Published: April 2024

Introduction: Biaryls are core structures composed of chiral ligands, organocatalysts, biologically active natural products and biopolymer lignins. In this study, the effects of basis sets, solvent models, and NMR methods on the accuracy of 1H/13C NMR chemical shift calculations for biaryl structures were evaluated.

Methods: All calculations were performed using Gaussian09. The GIAO NMR results were observed and extracted using GaussView05. To reduce the systematic error of the calculations, linear regression analysis of the calculated chemical shifts versus the experimental shifts was performed.

Results: The tested basis sets showed good 1H/13C results, with CMAE values as low as 0.0425 ppm and 1.09 ppm for 1H and 13C, respectively. The use of solvent models significantly increased the accuracy of the 1H chemical shift calculations. The GIAO method produced more accurate results than did the IGAIM and CSGT methods.

Conclusion: This study recommends 6-31G(d,p) and DGDZVP basis sets, IEMPCM and CPCM solvent models, and GIAO NMR methods for the accurate prediction of 1H and 13C chemical shifts for biaryls, assisting in their full structural assignments.
Polycyclic aromatic hydrocarbons (PAHs) in sediment environments in Vietnam: Analytical methods and contamination status
Authors:   Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong, Hanoi, Viet Nam, Nguyen Duc Hieu , Hoang Quoc Anh ,   Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong, Hanoi, Viet Nam, Tu Binh Minh ,   Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong, Hanoi, Viet Nam, Tran Manh Tri ,   University of Science, Vietnam National University, Hanoi, Dang Minh Huong Giang ,   Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong, Hanoi, Viet Nam, Hoang Bich Ngoc ,   Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong, Hanoi, Viet Nam, Vu Van Tu ,   Institute of Environmental Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Viet Nam, Nguyen Thi Hong Yen ,   National Institute of Hygiene and Epidemiology, 1 Yersin, Hanoi, Viet Nam, Shin Takahashi ,   Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Japan
Published: April 2024

Introduction: Polycyclic aromatic hydrocarbons (PAHs) are prevalent organic pollutants that garner attention due to their toxicity and carcinogenic properties. These hydrophobic compounds tend to accumulate in the organic components of sediments, posing significant ecological risks.

Methods: This study synthesizes analytical methodologies and assesses the contamination status of PAHs in Vietnamese sediments through a review of previous studies complemented by recent findings from our research group. Various extraction techniques, including Soxhlet extraction, pressurized liquid extraction, continuous solid-liquid extraction, and ultrasonic extraction, were employed using organic solvents of low to moderate polarity (e.g., hexane, acetone, toluene, dichloromethane). Purification was achieved via column chromatography using sorbents like silica gel, alumina, and Florisil, followed by gel permeation chromatography. Separation and analysis were primarily conducted through gas chromatography/mass spectrometry (GC/MS).

Results: PAHs were detected in all samples, with concentrations ranging from 33 to 6400 ng/g, indicating widespread contamination. The sources of PAHs in Vietnamese sediments appear to be predominantly urban and informal waste processing areas. The levels of sedimentary PAHs in Vietnam are on par with those reported in other Asian countries, with the majority of PAHs being traced back to pyrogenic sources, as opposed to petroleum products.

Conclusions: Our findings offer a detailed understanding of the distribution, patterns, and potential sources of PAHs in Vietnamese sediments. The notably higher concentrations of PAHs in urban and waste processing sites underscore the urgency of implementing effective management and remediation strategies. The study advocates for further monitoring of PAHs and related pollutants to fully elucidate their contamination scope, origins, and ecological consequences.
A simple method to estimate the pKa values of four fluorescent proteins based on measuring their pH-dependent absorbance spectra
Authors:   Hanoi National University of Education, Bui Thi Yen Hang , Tran The Nga ,   Hanoi National University of Education
Published: April 2024

Introduction: The Nobel Prize in Chemistry 2014 greatly recognized the application of fluorescent proteins (FPs) in superresolution imaging techniques. Subsequently, there has been a significant surge in FP-related investigations. Reversibly photoswitchable fluorescent proteins (rsFPs) are currently attracting much interest from scientists worldwide because of their unique ability to switch between bright and dark states. The pH-dependent photophysical behavior of rsFPs is mostly controlled by the equilibrium between four distinct states of the chromophores in FPs: trans-protonated, trans-deprotonated, cis-protonated, and trans-deprotonated. Thus, the pKa values of rsFP in general and its chromophore, in particular, are crucial factors in determining the fluorescence output of the settings containing rsFPs in different environments.

Methods: Here, we measured the absorbance spectra of four rsFPs in various buffers with different pH values to estimate their chromophore pKas. The relationship between the absorbance peak values for the anionic chromophore and pH is plotted, resulting in a sigmoid curve. Then, the apparent pKa of the chromophore is obtained by determining the inflection point of this curve.

Results: The pKa values for the cis-chromophores of two rsFPs (GMarsQ and Skylan-S) were obtained. Specifically, the pKa values for the trans-state of the chromophore in three rsFPs (Dronpa, GMarsQ, and rsEGFP2) were also estimated; these values have rarely been published.

Conclusions: This approach is quite straightforward but effective, enabling us to quickly estimate the pKa values of FPs generally and rsFPs specifically.
The overdue debt interest rate for late payment: From the precedent 09/2016/AL
Authors:   University of Economics and Law and VNU-HCM, Viet Nam, Trinh Hien Thuc , Nguyen Ngoc Truong ,   Hoa Sen University, Viet Nam
Published: April 2024

This essay analyzes the application of overdue debt interest rates on late payment, focusing on Precedent 09/2016/AL, Resolution No. 01/2019/NQ-HDTP, and subsequent court opinions interpreting them to access the appropriateness of "Legal Situation 1" and "Legal Solution 1" of the Precedent 09/2016/AL. Precedent 09/2016/AL commendably expands the scope of Article 306 of the 2015 Law on Commerce, applying it to a wider range of late payments than just purchase prices or service fees. However, the precedent's reliance on the average market rate for calculating interest collides with the specific regulations outlined in Resolution No. 01/2019/NQ-HĐTP. Crucially, we argue that Precedent 09/2016/AL's narrower interpretation compared to the original court opinion it draws from creates an unnecessary limitation. Therefore, we advocate for a broader application of Precedent 09/2016/AL, extending Article 306's reach to encompass all late payments, not just those related to payment of the purchase price or service fee. The interest rate calculation, meanwhile, would be guided by Resolution No. 01/2019/NQ-HDTP unless stipulated otherwise through the parties’ agreement. Importantly, this constructive rate should not serve as a ceiling for any interest rate negotiations between parties.
Towards to sustainable corporate performance through circular economy practices and corporate social responsibility in Vietnam
Authors:   Ho Chi Minh City University of Economics and Finance, Vietnam., Le Thanh Tiep
Published: April 2024

Modern technology has made it impossible to run a sustainably oriented business, particularly for small-to-medium enterprises (SMEs). The study examines the mediating role of eco-innovation (ECI) and green supply chain management (GSCM) in the food industry context in a developing country to inspect the nexus between corporate social responsibility ̣(CSR), circular economy practices (CEP) and sustainable corporate performance for SMEs. Smart PLS (version 4.0) structural method modeling (SEM) and quantitative methods were used to analyze 408 respondents collected from mid- to high-level managers in Vietnamese companies that work in the food industry. Results show that GSCM and ECI affect the sustainability of corporate performance. Furthermore, the research suggests that organizations and governments could promote ECI and GSCM in order to enhance CEP-SCP and CSR-SCP relationships. The study proposes some interesting implications that could assist high-level managers in an organization to attain sustainable performance. This study is significant because it highlights how CEP and CSR in GSCM and ECI might contribute to sustainability. Consequently, it encourages SMEs to implement operational and strategic reforms that have a major positive influence on the environment, society, and economy.
The impact of perceived value on customer satisfaction and brand loyalty: Research domestic coffee chains in Ho Chi Minh City
Authors:   University of Finance – Marketing, Vietnam, Nguyen Ha Thai
Published: April 2024

Brand loyalty is a factor that business units want to have, it shows consumers' commitment and preference for a brand compared to the brands of competitors. The impact of perceived value on customer satisfaction and brand loyalty is very important for business units operating in today's globally competitive context. By clarifying these influences, marketers can devise strategies to enhance customer satisfaction and brand loyalty from an understanding of perceived value. The objective of this research is to examine the impact of perceived value on customer satisfaction and brand loyalty for domestic coffee shop chains in Ho Chi Minh City, subsequently, suggesting some recommendations to increase satisfaction and brand loyalty for domestic coffee shop chains in this market. The research was conducted through the following stages: (i) Qualitative research using in-depth interviews and group discussions; (ii) Extensive research with 285 valid interviews; (iii) Formal research with 1,000 valid interviews, using a Likert scale with five points ranging from "Strongly disagree" to "Strongly agree" and collected data processed with Smart software PLS 3.0 with PLS-SEM technique.
Efek Moderasi dari Pengetahuan Pengalaman Internasional dalam Pengaruh Reputasi Perusahaan terhadap Akuisisi Lintas Negara
Authors: Edi Edi , Supriyanto Supriyanto , Aurelia Vanessa
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh moderating international experiential knowledge terhadap pengaruh reputasi perusahaan terhadap akuisisi lintas batas. Data sampel dalam penelitian ini meliputi 48 perusahaan yang terdaftar di Bursa Efek Indonesia yang memiliki corporate acquisition pada periode 2018-2021. Teknik pemilihan sampel yang digunakan adalah purposive sampling dengan metode analisis data berupa regresi logistik menggunakan aplikasi Smart PLS. Hasil penelitian menemukan bahwa reputasi memiliki efek negatif pada akuisisi lintas batas. Selain itu, hasil penelitian ini juga menemukan bahwa pengetahuan pengalaman internasional mampu memoderasi pengaruh yang signifikan dan positif terhadap hubungan reputasi perusahaan dan akuisisi lintas negara. Tingkat reputasi tinggi juga belum tentu merupakan langkah strategis. Reputasi yang dimiliki tidak cukup untuk dijadikan pondasi namun perlu diimbangi dengan pengalaman yang ada. Dengan demikian, perusahaan mampu mengurangi resiko dan lebih sadar akan hubungan berskala internasional.
Pengaruh Efisiensi dan Likuiditas terhadap Profitabilitas Perbankan Periode 2020-2022
Authors: Haryati Haryati , Roswinna Winna , Anggraeni Annisa Fitri
Published: April 2024

Ketidakpastian kondisi bisnis dimulai karena adanya COVID-19, segala pergerakan menjadi terhambat, hampir seluruh sektor yang ada mengalami dampak yang sangat serius, terutama perusahaan perbankan. Perbankan mengalami fluktuasi khususnya dari sisi penerimaan laba perusahaan. Tujuan Penelitian ini adalah mengetahui pengaruh efisiensi dan likuiditas dalam meningkatkan profitabilitas pada perbankan yang terdaftar di Bursa Efek Indonesia (BEI) Tahun 2020-2022. Populasi dalam penelitian ini adalah perbankan yang terdaftar di Bursa Efek Indonesia tahun 2020-2022 sebanyak 46 perbankan. Teknik sampling yang digunakan adalah non probability sampling dengan menggunakan teknik purposive sampling. sehingga, sampel yang digunakan pada penelitian ini sebanyak 15 perbankan dengan periode 3 tahun, sehingga berjumlah 45 sampel. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Teknik analisis data yang digunakan yaitu uji asumsi klasik, analisis regresi data panel, dan uji hipotesis. Hasil penelitian menunjukkan bahwa Efisiensi (BOPO) tidak berpengaruh terhadap profitabilitas (ROA). Kemudian, Likuiditas (LDR) berpengaruh terhadap profitabilitas (ROA). Efisiensi (BOPO) dan likuiditas (LDR) berpengaruh secara simultan terhadap profitabilitas (ROA). BOPO dan LDR berpengaruh terhadap ROA pada perbankan yang terdaftar di Bursa Efek Indonesia (BEI) Tahun 2020-2022 sebesar 61,3%, sedangkan sisanya 38,7% dipengaruhi oleh variabel bebas lainnya yang tidak dimasukkan dalam penelitian ini.
PENGARUH LEVERAGE DAN UKURAN PERUSAHAAN TERHADAP TAX AVOIDENCE
Authors: Rustiani Tri , Tyas Isthi Wahyuning , Juniarto Antonius
Published: April 2024

Abstrak

Perusahaan selalu berusaha untuk membayar pajak sesedikit mungkin, karena pajak mengakibatkan berkurangnya pendapatan. Dalam upaya meningkatkan efisiensi beban pajak, banyak perusahaan yang melakukan penghindaran pajak. Perusahaan property dan real estate menjadi objek karena saat ini perusahaan property dan real estate di Indonesia sedang berkembang pesat, kewajiban perpajakannya harus diperhatikan, karena membayar pajak merupakan hal yang penting bagi negara. Penelitian ini bertujuan untuk menganalisis pengaruh leverage dan ukuran perusahaan terhadap penghindaran pajak pada perusahaan properti dan real estate yang terdaftar di Bursa Efek Indonesia (BEI) periode 2017-2022. Penghindaran pajak dalam penelitian ini diukur dengan Effective Tax Rate (ETR). Penentuan sampel penelitian ini menggunakan metode purposive sampling dan diperoleh sampel penelitian sebanyak 46 perusahaan. Pengujian hipotesis dalam penelitian ini menggunakan metode regresi linier berganda dengan menggunakan Eviews versi 12. Hasil penelitian ini menunjukkan bahwa secara parsial variabel leverage tidak berpengaruh terhadap penghindaran pajak, variabel ukuran perusahaan berpengaruh positif dan signifikan terhadap penghindaran pajak. Dan secara simultan variabel leverage dan ukuran perusahaan berpengaruh positif dan signifikan terhadap penghindaran pajak.

Kata Kunci:  Leverage, ukuran perusahaan, penghindaran pajak
The Effect of Catfish Meat Substitution on the Physical and Organoleptick Quality Of Meatbals with Rejected laying HenMeat
Authors: Hafid Harapin , St Nur Anggraeni S  , Pagala Amrullah
Published: April 2024

Consumer pleasure for meatballs needs to be innovated with various ingredients including catfish meat and chicken meat. This study aims to determine the effect of catfish substitution on the physical and sensory quality of rejected laying hen meatballs. This study used an experimental method which is a completely randomized design (CRD) with 5 treatments and 5 repetitions. The treatment used was as follows, (P0) 100% meat of rejected layers, (P1) 80% meat of rejected layers: 20% catfish, (P2) 70% meat of rejected layers: 30% catfish, (P3) 60% meat of rejected layers: 40% catfish, (P4) 50% meat of rejected layers: 50% catfish. The parameters measured in this study were the organoleptic test of meatballs of rejected laying hen meat which had no significant effect (P>0.05) on all variables including color, shape, aroma, texture, taste and general acceptance of meatballs, aroma, tenderness, taste, texture and color of meatballs
Effect of Adding Synbiotic Isolate Pediococcus Pentosaceus Strain N6 and Cassava Peel Flour on the Digestibility of Dry Matter and Organic Matter of Super Native Chickens
Authors: Sukani  , N.br Ketaren  , S.Mutia R.M
Published: April 2024

Public awareness of healthy food is currently getting stronger.  Food should be free from antibiotics. As consequence the use of antibiotics as feed additives should be  prohibited because it has the potential to produce residues in livestock products and indirectly impact consumers. An alternative substitute for antibiotics that has been widely developed is the administration of synbiotics. Synbiotics are a combination of probiotics and prebiotics. The purpose of this study is to investigate Pediococcus pentosaceus strain N6 isolate as a probiotic and cassava peel as a prebiotic. The research design used was a non-factorial Completely Randomized Design (CRD) with 4 treatments and 5 replications. Each replication consisted of 5 chickens with treatments; P0: Basal ration without additive feed (control), P1: Basal ration + additive feed 150 ml/kg ration, P2: Basal ration + additive feed 300 ml/kg  ration and P3: Basal ration + additive feed 450 ml/kg ration. The best digestibility of dry matter and organic matter of super native chicken was obtained in treatment the addition of feed additives of 450 ml/kg ration. In conclusion feed additives of 450 ml/kg ration give good effect on digestibility as well as on feed consumption, dry matter consumption and organic matter consumption
Pengaruh Strategi Buzzer Dalam Amplifikasi Pesan Kepada Publik Pada Lingkungan Demokrasi Politik
Authors: Nurul Jannah Lailatul Fitria
Published: April 2024

Indonesia has been listed as a multifaceted Internet country. Even Indonesia ranks with a large number of Internet users in the world. People's use of the Internet and technology created communicators, such as infludilution and buzzer. The communicators represent digital marketing. The influence and the buzzer used social media to communicate information. Specifically, buzzer was not only the digital marketing of products and services but was transitively converted into political buzzers. It was based on this research to say the buzzer was the role of the casting of messages in a time of political democracy. Research USES descriptive qualitative methods by expounding a phenomenon in detail and the reality of a phenomenon with the results of data collection in the field. Collecting literature or literature data. To identify the buzzer, its message with the buzzer and buzzer in the maelstrom of political democracy. Some picture examples of amplifying the message by the buzzer led to negative democracy instead of positive democracy. There is amplification of messages that lead to false news, hate speech and black campaign. The conditions proved that the buzzer in the amplification of a democratic form of democracy went away mainly in the political sphere.
Gerakan Politik Agraria oleh Petani di Indonesia (Studi pada Serikat Petani Indonesia)
Authors: Randa Putra Kasea Sinaga  , Fajar Utama Ritonga  , Andry Anshari
Published: April 2024

Based on the transformation of the agrarian struggle into a political movement carried out by Serikat Petani Indonesia (SPI) as a mass peasant organization over the problem of inequality in agrarian control in Indonesia, this paper describes and analyzes how the pattern of agrarian political movements is carried out. By using data collection techniques such as literature studies and in-depth interviews at the SPI management level (from the base level in the village sector; the regional level in the provincial sector, as well as the central level in charge of the national and international sectors).By using the Narrative Research Analysis approach, the authors classify the patterns of political movements carried out by SPI, classified into local, national and international levels, each level having links as a pattern that is deemed necessary to synergize with each levels. SPI has taken actions from a social, economic, cultural, and political standpoint that are manifestations of views based on problems faced by peasants themselves. Based on the findings of this study, the authors believe that agrarian issues necessitate a massive multi-dimensional political movement that is justly oriented toward the interests of the people.
Kekalahan Partai Golkar pada Pemilihan Kepala Daerah Kabupaten Pelalawan Tahun 2020
Authors: Sianturi Stevan Togi Mandiri , Ekayanta Fredick Broven
Published: April 2024

Artikel ini bertujuan untuk menjelaskan mengapa kandidat yang diusung oleh Partai Golkar pada pemilihan kepala daerah Kabupaten Pelalawan tahun 2020 mengalami kekalahan. Padahal sebelumnya Partai Golkar selalu memenangkan kontestasi politik, baik dalam pemilihan legislatif maupun pemilihan kepala daerah di Pelalawan. Artikel ini berargumen bahwa kekalahan tersebut disebabkan oleh munculnya konflik internal, tidak adanya koalisi, dan faktor figur. Argumen tersebut dibangun berdasarkan kerangka teori yang dibangun melalui teori faksionalisasi partai politik, teori pilkada, dan konflik elite lokal. Artikel ini menganalisis data empirik yang dikumpulkan dari hasil wawancara mendalam dalam konteks keterlibatan DPD II Partai Golkar Pelalawan pada pemilihan kepala daerah tahun 2020. Wawancara mendalam tersebut dilakukan pada bulan Juni-Juli 2022. Artikel ini memperkuat teori faksionalisasi partai politik yang berdampak pada penurunan perolehan suara pada pemilihan umum, serta menegaskan bahwa dinamika pemilihan kepala daerah secara langsung di Indonesia sangat dipengaruhi oleh figur, bukan partai politik.