bluuebunny/crossref_metadata_2025 huggingface dataset:
N-doped CoSb@C nanofibers as a self-supporting anode for high-performance K-ion and Na-ion batteries
Authors: Han Jun , Zhu Kunjie , Liu Pei , Si Yuchang , Chai Yujun , Jiao Lifang
Published: October 2019

N-doped CoSb@C nanofibers as self-supporting anode improved K-ion and Na-ion storage.
Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications
Authors: Łapa Agata , Cresswell Mark , Campbell Ian , Jackson Phil , Goldmann Wolfgang H. , Detsch Rainer , Parsons Andrew , Ahmed Ifty , Boccaccini Aldo R.
Published: October 2019

Soluble Ga/Ce-doped phosphate glass fibres exhibiting controlled release of ions were developed and characterised for wound healing applications. Fibres did not disturb the proliferation and migration of cells and showed antibacterial properties.
Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent
Authors: Lee Sang Bong , Han Ye Ri , Jeon Hui-Jeon , Jun Chul-Ho , Kim Sang-Kyoon , Chin Jungwook , Lee Su-Jeong , Jeong Minseon , Lee Jae-Eon , Lee Chang-Hee , Cho Sung Jin , Kim Dong-Su , Jeon Yong Hyun
Published: October 2019

The novel fluorescent dye MF1 allows in vivo visualization of inflammatory lesions as well as the response to anti-inflammatory drug treatment by fluorescence imaging.
The quest for interpretable and responsible artificial intelligence
Authors: Belle Vaishak
Published: October 2019

Artificial intelligence (AI) provides many opportunities to improve private and public life. Discovering patterns and structures in large troves of data in an automated manner is a core component of data science, and currently drives applications in computational biology, finance, law and robotics. However, such a highly positive impact is coupled with significant challenges: how do we understand the decisions suggested by these systems in order that we can trust them? How can they be held accountable for those decisions?
A beginner's guide to single-cell transcriptomics
Authors: Lee Hojae , Yu Hengshi , Welch Joshua
Published: October 2019

Beginner's Guides each cover a key technique and offer the scientifically literate but not necessarily expert audience a background briefing on the underlying science of a technique that is (or will be) widely used in molecular bioscience. The series covers a mixture of techniques, including some that are well established amongst a subset of our readership but not necessarily familiar to those in different specialisms, or the reverse. This is our Beginner's Guide to single-cell transcriptomics.
Fighting for your life
Authors: Shearer Patrick D.A.
Published: October 2019

This is the ninth year the Biochemical Society has run the Science Communication Competition. The competition aims to give talented young science communicators the opportunity to have their work published in The Biochemist. This year's competition attracted entries from around the world covering a wide variety of topics, in both the written and video categories. The entries were judged by our expert panel of judges. In this issue we are proud to present the second place entry from the written category by Patrick D.A. Shearer.
Our path to 2021: Biochemical Society publishes its three-year strategy
Authors: Crabb Katie
Published: October 2019

The Biochemical Society launched its 2019–2021 strategy at its Annual General Meeting in July. This strategy sets out our aspirations and intentions for the next three years, building on progress from previous years, embedding lessons learned and developing new ambitions for 2019 and beyond.
A pilot study of blood supply of the coracoid process and the coracoid bone graft after Latarjet osteotomy
Authors: Deng Zhenhan , Liang Daqiang , Zhu Weimin , Liu Haifeng , Xu Jian , Peng Liangquan , Li Xuchun , Li Ying , Kotian Ronak Naveenchandra , Lu Wei , Wang Daping
Published: October 2019

Latarjet osteotomy is still one of the most reliable and commonly used surgeries in treating recurrent anterior shoulder dislocation. The coracoid process (CP) is the main structure of this surgery. However, the blood supply of CP is not fully understood, and the extent of destruction of blood supply of coracoid bone graft after Latarjet osteotomy procedure is still controversial. Five embalmed cadaveric upper limbs specimens were employed for macro observation of the blood supply of CP. The conjoint tendon (CT) and CP interface were dissected for histology. Sixteen fresh frozen shoulder specimens were used for perfusion and micro CT scanning. Eight specimens were used to present the whole vessel structure of CP. The other eight underwent Latarjet osteotomy procedure. The coracoid bone grafts in both groups were scanned to clarify the remnant blood supply. It was found that the CP was nourished by supra-scapular artery (SSA), thoracic-acromial artery and branch from second portion of the axillary artery (AA). After Latarjet osteotomy procedure, no artery from CT was detected to penetrate the CP at its attachment. Only in one specimen the blood vessel that originated from the CT penetrated the bone graft at the inferior side. Therefore, most of the blood supply was destroyed although there is a subtle possibility that the vessels derived from the CT nourished the inferior side of the CP. In a nutshell, CP is a structure with rich blood supply. The traditional Latarjet osteotomy procedure would inevitably cut off the blood supply of the coracoid bone graft.
miRNA-103 promotes chondrocyte apoptosis by down-regulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis
Authors: Li Fang , Yao Jianhua , Hao Qingqing , Duan Zheping
Published: October 2019

Objectives: The aim of the present study was to determine the effects of miRNA-103 on chondrocyte apoptosis and molecular mechanisms in osteoarthritis (OA) progression. Methods: The cell proliferation, apoptosis, and recovery ability were measured by cell counting kit-8 (CCK-8), flow cytometry, and wound healing assays. The interaction of miRNA-103 and Sphingosine kinase-1 (SPHK1) were determined by using luciferase reporter assay. The expression of mRNA and proteins were measured by qRT-PCR and Western blot. OA rat model was established by surgery stimulation. Results: miRNA-103 expression was significantly increased in the cartilage of OA patients and surgery-induced OA rat models. miRNA-103 transfection into primary rat chondrocytes reduced SPHK1 expression, induced apoptosis, inhibited cell proliferation, and impeded scratch assay wound closure. Moreover, expression of total AKT, and p-AKT were significantly reduced in miRNA-103-overexpressing chondrocytes while SPHK1 up-regulation increased the expression of phosphatidylinsitol-3-kinase (PI3K) and p-AKT, and reversed the proliferation suppression induced by the miRNA-103 mimic. Conclusions: Our studies suggest that miRNA-103 contributes to chondrocyte apoptosis, promoting OA progression by down-regulation of PI3K/AKT pathway through the reduction in SPHK1 activity.
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion
Authors: Zein Aiman A. , Kaur Rupinder , Hussein Toka O.K. , Graf Gregory A. , Lee Jyh-Yeuan
Published: October 2019

The ABCG5/G8 heterodimer is the primary neutral sterol transporter in hepatobiliary and transintestinal cholesterol excretion. Inactivating mutations on either the ABCG5 or ABCG8 subunit cause Sitosterolemia, a rare genetic disorder. In 2016, a crystal structure of human ABCG5/G8 in an apo state showed the first structural information on ATP-binding cassette (ABC) sterol transporters and revealed several structural features that were observed for the first time. Over the past decade, several missense variants of ABCG5/G8 have been associated with non-Sitosterolemia lipid phenotypes. In this review, we summarize recent pathophysiological and structural findings of ABCG5/G8, interpret the structure-function relationship in disease-causing variants and describe the available evidence that allows us to build a mechanistic view of ABCG5/G8-mediated sterol transport.
RecA and DNA recombination: a review of molecular mechanisms
Authors: del Val Elsa , Nasser William , Abaibou Hafid , Reverchon Sylvie
Published: October 2019

Recombinases are responsible for homologous recombination and maintenance of genome integrity. In Escherichia coli, the recombinase RecA forms a nucleoprotein filament with the ssDNA present at a DNA break and searches for a homologous dsDNA to use as a template for break repair. During the first step of this process, the ssDNA is bound to RecA and stretched into a Watson–Crick base-paired triplet conformation. The RecA nucleoprotein filament also contains ATP and Mg2+, two cofactors required for RecA activity. Then, the complex starts a homology search by interacting with and stretching dsDNA. Thanks to supercoiling, intersegment sampling and RecA clustering, a genome-wide homology search takes place at a relevant metabolic timescale. When a region of homology 8–20 base pairs in length is found and stabilized, DNA strand exchange proceeds, forming a heteroduplex complex that is resolved through a combination of DNA synthesis, ligation and resolution. RecA activities can take place without ATP hydrolysis, but this latter activity is necessary to improve and accelerate the process. Protein flexibility and monomer–monomer interactions are fundamental for RecA activity, which functions cooperatively. A structure/function relationship analysis suggests that the recombinogenic activity can be improved and that recombinases have an inherently large recombination potential. Understanding this relationship is essential for designing RecA derivatives with enhanced activity for biotechnology applications. For example, this protein is a major actor in the recombinase polymerase isothermal amplification (RPA) used in point-of-care diagnostics.
(g−2)µ at four loops in QED
Authors: Marquard Peter , Smirnov Alexander V. , Smirnov Vladimir A. , Steinhauser Matthias , Wellmann David
Published: October 2019

We review the four-loop QED corrections to the anomalous magnetic moment of the muon. The fermionic contributions with closed electron and tau contributions are discussed. Furthermore, we report on a new independent calculation of the universal four-loop contribution and compare with existing results.
Recent Hadronic Cross Section Measurements from BABAR
Authors: Griessinger Konrad
Published: October 2019

New hadronic cross sections measured by the BABAR experiment are presented: e+e−→ π+π−π0π0, e+ e−→ π+π−η, and the kaonic channels e+e−→ KS KLπ0 , KS KLπ0π0 , KS KLη, KS K±π+π0 , KS K±π+η.
Status of Measurement of R Value at BESIII
Authors: Yan Wenbiao
Published: October 2019

The R value is important for muon magnetic moment aµ and QED running coupling constant evaluated at Z pole, is useful to extract resonance parameters. BESIII experiment collected about 130 energy points between 2.0GeV and 4.6GeV for a precise measurement of R value. The status of R measurement at BESIII is reported in this paper.
Direct, Resonant Production of States with Positive Charge Conjugation in Electron-Positron Annihilation
Authors: Czyż Henryk , Kühn Johann H. , Tracz Szymon
Published: October 2019

Recent theory results on direct production of resonances with positive charge conjugationin electron-positron annihilation are reviewed. The strong modeldependence is emphasized, with predictions varying between 0.03 eV and 0.43 eV for the charmonium state with JPC = 1++ and between0.16 eV and4.25 eV for the state with JPC =2++. For the state with JPC = 0++ the cross section is of O $ \left( {\mathop m\nolimits_e^2 /\mathop M\nolimits_x^2 } \right) $ and thus negligeable for all practical purpose. The importance of the relative phase of the production amplitude is emphasized.
Hadronic Cross Section Measurements at Belle and perspectives for BELLE-II
Authors: Shwartz B.
Published: October 2019

Large data amount, about 1 ab−1 of integrated luminosity, collected in experiments with the Belle detector provided a good possibilities for precise measurements of the hadronic cross sections in e+e− annihilation. Main results obtained in this field with the Belle detector as well as perspectives of the new experiments with the Belle II detector at the SuperKEKB collider is discussed in this report.
Dispersive analysis of light-meson transition form factors
Authors: Kubis Bastian
Published: October 2019

We discuss status and prospects of a dispersive analysis of the π0, η, and η ′ transition form factors. Particular focus is put on the various pieces of experimental information that serve as input to such a calculation. These can help improve on the precision of an evaluation of the light pseudoscalar pole contributions to hadronic light-by-light scattering in the anomalous magnetic moment of the muon.**
Radiative corrections to elastic-electron proton scattering and uncertainty in proton charge radius
Authors: Arbuzov Andrej , Kopylova Tatiana
Published: October 2019

Higher-order QED radiative corrections to elastic electron-proton scattering are discussed. It is shown that they are relevant for high-precision experiments on proton form factor measurements. Analytic result are obtained for next-to-leading second order corrections to the electron line. Light pair corrections are taken into account. The role of the hadronic contribution to vacuum polarization is discussed. Numerical results are given for the conditions of the experiment on proton form factors performed by A1 Collaboration. Preliminary results are also shown for the set-up with reconstruction of momentum transfer from the recoil proton momentum.
Experimental review of τ lepton studies at the B factories
Authors: Epifanov Denis
Published: October 2019

Recent results of a high-statistics τ lepton studies at B factories are reported. Reviewed are the measurements of Michel parameters in leptonic and radiative leptonic τ decays at Belle, as well as the measurement of the branching fractions of the radiative leptonic τ decays at BABAR. Searches for CP symmetry violation in hadronic decays with $ \mathop K\nolimits_S^0 $ are also briefly discussed.
Heavy-quark spin-symmetry partners of Zb(10610) and Zb(10650) molecules
Authors: Baru V. , Epelbaum E. , Filin A. A. , Hanhart C. , Nefediev A. V.
Published: October 2019

Heavy-quark spin-symmetry (HQSS) partners of the isovector bottomonium like states Zb(10610) and Zb(10650) are predicted within the molecular picture. Treating both Zb’s as shallow bound states, we solve the system of coupled-channel integral equations for the contact plus one-pion exchange (OPE) potentials to predict the location of the partner states with the quantum numbers J++ (J = 0,1,2). In particular, we predict the existence of a narrow tensor 2++ state residing a few MeV below the B∗ B¯∗ threshold. It is emphasised that the tensor part of the OPE potential in combination with HQSS breaking due to the nonvanishing B∗ -B mass splitting has a significant impact on the location of this partner state.
Nouveaux travaux pratiques en nanotechnologies : étude nano-mécanique de micro/nano-objets mous/souples par AFM
Authors: Gautier R. , Petit C. , Bolcato V. , Planus E. , Marchi F.
Published: October 2019

La caractérisation des propriétés mécaniques de micro et nano-systèmes devient cruciale pour le développement des (bio)MEMS/NEMS. Comme la microscopie à force atomique (AFM) est un instrument de choix pour mesurer les propriétés morphologiques et mécaniques à l’échelle submicronique, nous avons développé un TP AFM en mode Peak Force sur cette thématique. Les étudiants effectueront la cartographie 4D d’un échantillon de polymères dont les propriétés mécaniques sont bien différentes. À partir de ces cartographies AFM, les étudiants estimeront les modules de Young en sélectionnant le(s) modèle(s) les plus adéquats. Le savoir-faire ainsi acquis sera ensuite appliqué lors d’un second TP à une cellule de souris fixée pour estimer ses propriétés viscoélastiques.
Approche des laboratoires sur puce par l’expérimentation : projet MyLOC
Authors: Français O. , Bourouina T. , Lissorgues G. , Rousseau L. , Couty M. , Mercier B.
Published: October 2019

Au sein de l’établissement ESIEE-Paris, nous avons mis en place des enseignements de niveau Master autour des laboratoires sur puce (Unité MyLOC : My Lab On Chip). Ces enseignements ont une approche type « learning by doing » avec l’utilisation de bureau d’étude où les élèves découvrent la thématique au travers de problématiques scientifiques et industrielles auxquelles ils doivent proposer des solutions. Cet article présente la partie microfluidique de ces enseignements (de la conception au test). Les élèves abordent d’abord la microfluidique sur la conception et analyse d’un circuit microfluidique afin de garantir son bon fonctionnement pour une application donnée (ici un test de Emmel sur puce pour la détection de cellules drépanocytaires). Les élèves apprennent ensuite à simuler son fonctionnement à l’aide d’un logiciel numérique multiphysique. Ils réalisent alors un prototype de puce en salle blanche et le testent afin de confronter les résultats aux modèles (analytique et numérique) mis en oeuvre. Cette approche pédagogique très fortement orientée sur l’expérience a eu des retours très positifs. Cet enseignement a bénéficié de l’appui des Initiatives Pédagogique Innovantes de l’université Paris-EST (IDEA) et du CEMIP (Pôle parisien du CNFM).
Développement de solutions hyperfréquences pour la société moderne : Bio-radar et Microscopie électromagnétique
Authors: Haddadi K. , Szymik D. , Hoel V. , Dambrine G.
Published: October 2019

Cet article décrit le projet de fin d’étude mis au point au sein du Master Réseaux et Télécommunications parcours SYSCOM (Systèmes Communicants) de l’Université de Lille. Le projet vise à développer des solutions hyperfréquences pour la ville intelligente (Smart City). Les développements techniques et scientifiques reposent sur la plate-forme hyperfréquence du GIP-CNFM de Lille qui comprend toutes les installations nécessaires pour mener à bien un projet complet comprenant l'analyse, la conception et la réalisation de composants et circuits hyperfréquences. En particulier, deux projets menés de concert sont décrits. Le premier projet vise à développer un radar hyperfréquence monostatique opérant à 6,2 GHz pour la mesure sans contact des fréquences respiratoire et cardiaque d’un individu. Le deuxième projet ambitionne de développer un microscope électromagnétique original pour le Contrôle Non Destructive (CND) de matériaux à haute résolution spatiale. Un cahier des charges en terme de coût, de performances de mesure et de possibilités d’intégration est défini préalablement avec pour objectif de développer des solutions économiques viables.
AMUSE : l'escape game pour s'évader en toute sécurité
Authors: Bruguier F. , Benoit P. , Dalmasso L. , Pradarelli B. , Lecointre E. , Torres L.
Published: October 2019

L'Internet des objets (IoT) voit l'apparition d'objets de plus en plus connectés. Dans un tel contexte, l’aspect sécurité de ces objets est plus important que jamais. C'est pourquoi nous avons développé plusieurs cours sur la sécurité matérielle. Les cours de sécurité traditionnels commencent souvent par un catalogue de définitions qui peuvent parfois être ennuyeuses pour les étudiants et donc contre-productives. Cette étude décrit un « escape game » utilisé comme séquence pour introduire plusieurs concepts de sécurité. Ce jeu sérieux pourrait être adapté au niveau de diplôme des étudiants.
Actions de sensibilisation à la microélectronique envers les lycéens dans le cadre du projet Nano@school
Authors: Excoffon E. , Bsiesy A. , Berger S. , Bonnaud O.
Published: October 2019

Ce papier présente les expériences de sensibilisation à la microélectronique et aux nanotechnologies de lycéens menées dans le cadre du programme Nano@school à Grenoble. A l’origine de ce programme, qui fête ses dix années d’existence en 2019, se trouvent trois partenaires : le CEA de Grenoble, le pôle CNFM de Grenoble (CIME Nanotech), et le Rectorat de Grenoble. Depuis 2012, ce programme est inclus dans une des actions du projet piloté par le réseau national de formation à la microélectronique (CNFM) et dont le CIME Nanotech est un membre majeur. Il est en effet très important de pouvoir attirer les jeunes dans ces domaines scientifiques qui sont souvent mal connus et où cependant la demande de main d’oeuvre qualifiée est importante. Les sessions se déroulant sur une journée proposent aux lycéens de véritables mini-projets scientifiques, à travers des expérimentations encadrées par des enseignants et/ou chercheurs sur des plateformes technologiques ayant des équipements de pointe. La sensibilisation est donc basée essentiellement sur un travail pratique dans un environnement de formation universitaire et de recherche. Le retour d’expérience indique que l’approche est globalement très bien perçue par les lycéens et par leurs professeurs, très motivante pour les organisateurs et encadrants sur les plateformes, mais son impact sur l’attractivité reste néanmoins difficile à mesurer à court terme.
Diel changeover of fish assemblages in shallow sandy habitats of lowland rivers of different sizes
Authors: Nowak Michał , Klaczak Artur , Koščo Ján , Szczerbik Paweł , Fedorčák Jakub , Hajdú Juraj , Popek Włodzimierz
Published: October 2019

Diel dynamics of species richness and fish abundance were studied in three lowland rivers that differed significantly in size (discharge) in to the upper Vistula River drainage system (Poland). Shallow sandy habitats at point bars were repeatedly sampled with beach seining over 24-h periods. Species richness peaked at dusk and then decreased throughout the 24-h period in all the rivers. Overall fish abundance changed similarly in the smallest and the largest river, whereas in the mid-sized river it increased in the late afternoon hours. Some species (three gudgeon species, golden loach, and chub) were persistently nocturnal, whereas others (dace, bleak, and roach) shifted to diurnal activity in the mid-sized and large rivers. These differences in diel changes in the abundance of certain species might be explained in the context of variation in availability (i.e., proximity) of other, more heterogeneous habitats.
An approach to design a distributed knowledge-based platform for energy efficient cities
Authors: Vitliemov Pavel , Bratanov Daniel , Marinov Milko
Published: October 2019

In this paper is presented an approach to design distributed knowledge-based software environment for energy efficient cities. All data gathered by the smart tools at domestic or public facilities can be accessed by the platform. Energy savings can be achieved as result from an optimized mix of both condition-based and preventive energy losses services that followed an online analysis of collected data. Algorithms and methods for an intelligent interpretation of the collected data can be developed within the platform in order to monitor the energy consumption process. Simulation of different scenarios forecasting the consumer’s further behaviour in energy consumption will be the result of that intelligent interpretation.
ARCHITA: an innovative multidimensional mobile mapping system for tunnels and infrastructures
Authors: Foria Federico , Avancini Gabriele , Ferraro Ricardo , Miceli Gabriele , Peticchia Esther
Published: October 2019

This paper presents ARCHITA: an innovative multidimensional mobile mapping system for the survey and the diagnostic of tunnels and infrastructures. The system gives the outputs of geometry and structures conditions in an integrated environment. The paper provides a brief description of the system and the successful application to support the decision-makers and the designers. Moreover, the outputs of the system are presented throughout the paper for different tunnels.
Standardized system for evaluating groundwater pollution
Authors: Yakoub Khemmal Hichem , Azzedine Hani
Published: October 2019

This paper presents a methodology that will permit the groundwater pollution potential of any hydrogeologic setting to be systematically evaluated. Pollution potential is a combination of hydrogeologic factors, anthropogenic influences and source of contamination in any given area. This methodology includes only the hydrogeologic factors which influence pollution potential.
Applicability of UH model to coarse-grained soil
Authors: Zhao Xiaolong , Zhu Jungao , Bian Hanbing
Published: October 2019

Large-scale triaxial, K0 compression and constant stress ratio path tests were carried out on two kinds of coarse-grained soils. Stress-strain relationships of these tests were simulated by using UH model for sands to study the applicability of the model to different stress paths of coarse-grained soil, and the results were compared with those of Duncan’s E-B model. It is shown that the mechanical behaviors of coarse-grained soil can be well described by the UH model, and overall its capacity to reflect stress-strain relationship under different stress paths is better than that of Duncan’s E-B model. Finally, the UH model and Duncan’s E-B model were used for stress-deformation analysis of a core rockfill dam. The applicability of UH model for sands to coarse-grained soil was verified.
Cent ans après, le retour de la phagothérapie ?
Authors: Jordan Bertrand
Published: October 2019

Bacteriophages were advocated as therapeutic agents more than a century ago, but the advent of antibiotics relegated them to a very minor role. Today, multi-drug resistant bacteria are a serious health problem, and phage therapy enjoys renewed interest. Recent publications show that it can be effective, but also highlight the serious logistic problems involved in using this approach.
La santé à l’ère du numérique
Authors: Santiago Antoine , Carré Arnaud , Miranda Ruben , Benyamina Amine , Luquiens Amandine
Published: October 2019

Les technologies de l’information et de la communication ont profondément marqué le champ de la santé. De nouvelles pratiques médicales utilisant ces technologies tentent de promouvoir une meilleure égalité d’accès aux soins, en particulier dans le champ de la santé mentale et des addictions où le recours aux professionnels de santé demeure faible. L’addiction aux jeux de hasard et d’argent en ligne, que nous désignerons sous le terme de jeu problématique, semble représenter un modèle pertinent de mesures de prévention et de soin fondé sur l’exploitation des données numériques issues du Big data et sur l’utilisation des nouvelles technologies. Ens effet, les données issues des comptes des joueurs offrent la possibilité d’une lecture directe de leur comportement de jeu. Parallèlement, le recours à l’internet offre un cadre de soin auquel les joueurs en ligne pourraient être particulièrement sensibles.
Multimorbidität bei älteren psychiatrischen Patienten
Authors: Junghanns Klaus , Wetterling Tilman
Published: October 2019

Hintergrund Multimorbidität stellt eine große Herausforderung in der Altersmedizin dar.

Methodik Darstellung explorativer Daten aus der Gerontopsychiatrie Studie Berlin (Gepsy-B), in der über einen Zeitraum von 3 Jahren Daten von 941 älteren stationären Patienten erfasst wurden.

Ergebnisse 94,2 % der Patienten litten an zumindest einer chronischen somatischen Erkrankung, im Mittel an 2,70 + 1,39, wobei die Anzahl mit dem Alter stieg (r = 0,257, p <,001). Die häufigsten waren zerebrovaskuläre (56,5 %) und Herzerkrankungen (52,2 %) sowie Hypertonus (54.8 %) und Diabetes mellitus Typ II (37,5 %). Zusätzlich litten viele Patienten an schweren körperlichen Beeinträchtigungen wie Bewegungsstörungen (26,2 %), schwerer Hypakusis (16,5 %), Inkontinenz (15,1 %) und ausgeprägter Sehminderung (7,4 %). Organische Hirnschädigungen waren dabei besonders häufig mit chronischen somatischen Erkrankungen oder Beeinträchtigungen assoziiert.

Schlussfolgerung Ältere psychiatrisch erkrankte Patienten haben oft zugleich eine ausgeprägte somatische Multimorbidität, die den Behandlungserfolg wesentlich mit beeinflussen dürfte.
Successful treatment of a mucous membrane pemphigoid in a young dog
Authors: Udraite Vovk Laura , Klinger Christoph J. , Böhm Teresa M. S. A. , Gedon Natalie K. Y. , Bettenay Sonya V. , Mueller Ralf. S.
Published: October 2019

Mucous membrane pemphigoid was diagnosed in a 2.5-year-old male intact foxhound-beagle cross which was presented with an acute onset of non-pruritic, multifocal, slowly progressive erosive-ulcerative dermatitis predominantly affecting the nasal planum, eyelids and muzzle with multiple vesicles on the inner pinnae, oral mucosa and tongue. The diagnosis was based on clinical signs and histological examination of skin biopsies. The patient did not respond to immunosuppressive prednisolone therapy, but went into complete remission with oral doxycycline and niacinamide and stayed in remission on long-term exclusive niacinamide treatment.
Klinische Kardiotoxizität bei Hunden nach Doxorubicintherapie
Authors: Betz Daniela Simon
Published: October 2019

Hallman BE, Hauck ML, Williams LE et al. Incidence and risk factors associated with development of clinical cardiotoxicity in dogs receiving doxorubicin. J Vet Intern Med 2019; 33: 783–791.

Doxorubicin ist ein wichtiges Zytostatikum in der Behandlung vieler Tumorerkrankungen beim Hund. Eine klinisch relevante, vor allem kumulative Kardiotoxizität ist als unerwünschte Wirkung dieser Substanz beim Menschen gut charakterisiert. Beim Hund sind doxorubicinassoziierte kardiale Effekte hingegen nur wenig untersucht. Ziel dieser Studie war, die Inzidenz klinischer Kardiotoxizität nach Doxorubicinbehandlung beim Hund zu erheben sowie Risikofaktoren für deren Entwicklung zu identifizieren.
Mechanical Performance of a Polyaxial Locking Plate and the Influence of Screw Angulation in a Fracture Gap Model
Authors: Kaczmarek Jakub , Bartkowiak Tomasz , Schuenemann Riccarda , Paczos Piotr , Gapinski Bartosz , Bogisch Sandra , Unger Martin
Published: October 2019

Objective The aim of this study was to compare the locking compression plate (LCP) with polyaxial locking system (PLS) using single cycle to failure 4-point bending test and to investigate the behaviour of PLS with screws inserted mono- and polyaxially using cyclic fatigue test in two bending directions.

Materials and Methods Tests were performed on bone surrogates in a fracture gap model. The 3.5 LCP and 3.5 PLS plates were tested in single cycle to failure. The 3.5 PLS plates with mono- and polyaxial screws were compared in a cyclic fatigue tests in two orthogonal directions. For both experiments, micro-computed tomography (CT) scans were performed pre- and post-testing to investigate the connections between the screw head and the plate hole. Means of forces and cycles needed to failure were statistically compared.

Results The PLS plates were on average 30% weaker than LCP plates. Mode of failure was plate bending in the single cycle to failure tests, and plate breakage in the cyclic fatigue tests. Neither screw breakage nor loss of the screw–plate interface occurred. Mono- and polyaxial constructs performed similarly when loaded in the same direction. Micro-CT revealed no additional internal cracks in the plates or screws after testing. It also showed for both PLS and LCP that there was only partial contact of the screw head with the plate hole.

Clinical Relevance PLS offers a durable locking system, even when the screws are placed polyaxially. The weaker bending properties of the PLS compared with LCP should be considered during preoperative planning.
Uncus Herniation Presenting as Immediate Onset Postoperative Hemichorea
Authors: Agarwal Vinay , Singhal Namit
Published: October 2019

Chorea is defined as a state of excessive spontaneous movements, irregularly timed, nonrepetitive, randomly distributed, and abrupt in character. Thalamic and subthalamic lesions are commonly known to cause hemichorea. Here, we describe a patient with hydrocephalus due to aqueductal stenosis that caused hemichorea in the immediate postoperative period due to subthalamic infarct of uncus herniation. Considering that hydrocephalus symmetrically affects the central nervous system, the asymmetric presentation of chorea in the immediate postoperative period after wakening up from anesthesia could be confusing if a possibility of uncus herniation is not considered.
Acute Motor Axonal Neuropathy in a 5-Month-Old Child
Authors: Sullo Federica , Motta Milena , Smilari Pierluigi , Rampello Luigi , Greco Filippo , Pavone Piero
Published: October 2019

Guillain–Barré syndrome (GBS) is an acute inflammatory polyneuropathy characterized by rapidly progressive, essentially symmetric weakness and areflexia in a previously otherwise healthy child. It is the most common cause of acute flaccid paralysis in children, and its reported incidence is 1 to 2/100,000 population. Prior infection is a well-established predating event in GBS. The commonly recognized variants of GBS are acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy, and Miller–Fisher syndrome. AIDP is the most prevalent form. As Guillain–Barrè syndrome represents an important differential diagnosis in infancy with pronounced and progressive hypotonia, we herein report a case of AMAN in a 5-month-old male infant without known exposure to immunomodulating factors or infections.
Role of the Interventional Radiologist in Pancreatic Whole Organ and Islet Cell Transplantation
Authors: Shah Ketan Y. , Simpson Russell O. , Wang Yifan , Okoye Obi T. , Pandhi Mithil B. , Desai Shamit S. , Almario Alvarez Jorge A.
Published: October 2019

Pancreas transplantation is an exciting therapy which has been used for several decades in the treatment of diabetes mellitus. It can be performed as either a whole organ or islet cell transplant. The role of interventional radiologists in the management of whole organ transplants is evolving and includes treatment of postoperative complications and graft biopsy to evaluate for rejection. An in-depth understanding of the transplant anatomy and variations is a fundamental tool in performing these interventions successfully. Islet cell transplantation entails delivery of purified donor pancreatic islet cells into the recipient portal vein. Because of their expertise in image-guided access to the portal system, interventional radiologists play a crucial role in this procedure. The purpose of this article is to review the indications, anatomy, complications, and outcomes of both whole organ and islet cell pancreas transplants, followed by a discussion of the role of interventional radiologists in each procedure.
Base transport factor and frequency response of transistor lasers
Authors: Li Yue , Leburton Jean-Pierre
Published: October 2019

We report on a charge control analysis that relates the characteristic time constants of a three-port laser made of a quantum-well (QW) heterojunction bipolar transistor (HBT) to the electronic gain of the device. For this purpose, we take into account the linear variation of the base transport factor α with the HBT base current. Our approach enables us to obtain QW capture time, base recombination lifetime, and base transit time in terms of the experimental values of base current and of the transistor laser (TL) design parameters such as base width, QW width, and QW location. Whereas the base recombination lifetime is calculated to be a fraction of a nanosecond, the QW capture time is found to be of the order of a picosecond or less. The time constants obtained from our model are used to successfully reproduce the TL experimental optical frequency response.
Design and fabrication of crotch absorbers with beryllium diffuser for Cornell high energy synchrotron source upgrade
Authors: Liu X. , Li Y. , Lyndaker A. , Conway J. , Smolenski K. W. , Woll A. R. , Smieska L. M.
Published: October 2019

With the CHESS-U upgrade in 2018, the south arc region of Cornell Electron Storage Ring (CESR) has been replaced with new magnets and vacuum chambers, and CESR will operate with higher beam energy and beam current at lower beam emittance. A new crotch absorber has been designed for the upgrade, based on previous CHESS crotch absorbers. The main body of the crotch absorber is a water-cooled hollow cylinder made of oxygen-free high-conductivity copper, and it has a 5-mm thick beryllium band brazed on the outside in the middle section to reduce the power density it absorbs on the surface. In this paper, we describe the mechanical design, present finite element thermal and structural analysis results with a focus on the region with high temperature and high thermal stress, and discuss the fatigue lifetime of the absorber. For typical operation with 6 GeV beam energy and a 200 mA beam current, the highest temperature on the crotch is approximately 300 °C based on the thermal analysis. Correspondingly, the fatigue lifetime is conservatively estimated to be around 4 × 104 cycles. We also show some details in the fabrication of the crotch assembly, especially about the vacuum furnace brazing joint between the beryllium band and the copper main body, including X-ray fluorescence inspection of the brazing joint. In addition, in order to have a relevant comparison in an effort to estimate the fatigue lifetime, we carry out finite element analyses (FEA) for the low cycle fatigue experiment with beryllium tiles using electron-beam heating of Watson et al. [Fusion Eng. Des. 37, 553 (1997)] in 1990s and provide new understanding for some of their experimental observations. These analyses assure the effectiveness of the design.
Experimental evidence of more than one ions acceleration mechanisms in plasma focus device: Observations and interpretations
Authors: Jain Jalaj , Moreno José , Davis Sergio , Bora Biswajit , Pavez Cristian , Avaria Gonzalo , Soto Leopoldo
Published: October 2019

Charged particle (CP) measurements in dense plasma focus (DPF) devices are important to understand the fundamentals of the CP acceleration mechanism, which is under active investigation. In this work, the results of the CP (ion) measurements obtained from a kilojoule DPF device, PF-2 kJ, are presented. The ion signals were observed in the pressure range of 3–11 mbar of hydrogen gas. The ion signals were recorded by means of Faraday cups (FCs). One FC was mounted in the axial direction, and two FCs were mounted in radial directions (at 180° to each other). Three distinct signals of ions were observed in the FC that was in the axial direction and two in the FCs that were in the radial direction. Later, the ion signals were converted into number densities [NDs (m−3)] at each pressure. The maximum NDs were found at 3 mbar in both directions. The variation in the NDs with pressures suggests the existence of more than one ion acceleration mechanism in the PF-2 kJ. Moreover, at the lower pressures (3 mbar), ion emissions are observed before the dip in the current derivative, which suggests that there are acceleration mechanisms acting not only in the pinch stage but also during the radial compression.
Accurate non-bonded potentials based on periodic quantum mechanics calculations for use in molecular simulations of materials and systems
Authors: Naserifar Saber , Oppenheim Julius J. , Yang Hao , Zhou Tingting , Zybin Sergey , Rizk Mohamed , Goddard William A.
Published: October 2019

Molecular dynamics simulations require accurate force fields (FFs) to describe the physical and chemical properties of complex materials and systems. FF parameters for valence interactions can be determined from high-quality Quantum Mechanical (QM) calculations. However, it has been challenging to extract long-range nonbonded interaction potentials from QM calculations since there is no unambiguous method to separate the total QM energy into electrostatics (polarization), van der Waals (vdW), and other components. Here, we propose to use density functional theory with dispersion corrections to obtain the equation of state for single element solid systems (of H, C, N, O, F, Cl, Br, I, P, He, Ne, Ar, Kr, Xe, and Rn) from which we obtain the pure 2-body vdW nonbonded potentials. Recently, we developed the polarizable charge equilibration (PQEq) model based on QM polarization energy of electric probe dipoles with no contributions from vdW. Together, the vdW and PQEq interactions form the nonbonded potential of our new transferrable reactive FF (RexPoN). They may also be useful to replace the nonbonded parts of standard FFs, such as OPLS, Amber, UFF, and CHARMM. We find that the individual 2-body vdW potential curves can be scaled to a universal vdW potential using just three specific atomic parameters. This simplifies extension to the rest of the periodic table for atoms that do not exhibit molecular packing. We validate the accuracy of these nonbonded interactions for liquid water, energetic, and biological systems. In all cases, we find that our new nonbonded potentials provide good agreement with QM and experimental data.
Terahertz radiation from multi ion plasma irradiated by two cross focused Gaussian laser beams
Authors: Jafari M. J. , Jafari Milani M. R. , Rezaei S.
Published: October 2019

Terahertz (THz) radiation generation by nonlinear coupling of two color Gaussian laser beams in a plasma with multi-ion species is numerically investigated by taking into account the nonlinearity due to ponderomotive force and space-charge field. By calculating the modification of electron density distribution of such plasma, coupled differential equations governing the evolution of two laser beams' spot size and the outcome THz wave amplitude are established. The influence of the ionic species density and charge composition on the cross focusing of laser beams as well as generation of THz radiation is studied. The results mainly demonstrated that nonlinear effects in a multiply ionized plasma are excited stronger in comparison to the singly ionized one. It was found that the presence of ion species of higher charge enhances the cross focusing of beams and, consequently, THz field amplitude. The generated THz emission also strongly depends on the density of ionic species. The results showed that the minimum output of THz radiation is related to the higher density of singly charged ionic species. Moreover, it was found that the maximum value of THz amplitude takes place within a specific range of laser intensities.
Fluidization behavior monitoring of phosphogypsum in cyclone separator using electrical capacitance tomography
Authors: Hao Zhenhua , Wang Huaxiang , Sun Benyuan , Cui Ziqiang
Published: October 2019

The fluidized behavior and the concentration distribution of phosphogypsum in the cyclone separator are studied and analyzed using twin-plane electrical capacitance tomography. Particle concentration is relatively low in the central region of the cyclone separator, and the concentration near the side wall of the cyclone separator is relatively high. With the increase in wind velocity, the radial particle concentration decreases, and the separation efficiency increases first and then decreases. Finally, regression analysis is used to fit the radial concentration distribution data of phosphogypsum. The analysis results are helpful to improve the cyclone structure and separation efficiency and to optimize the size of the cyclone separator.
Super-resolution energy spectra from neutron direct-geometry spectrometers
Authors: Islam Fahima , Lin Jiao Y. Y. , Archibald Richard , Abernathy Douglas L. , Al-Qasir Iyad , Campbell Anne A. , Stone Matthew B. , Granroth Garrett E.
Published: October 2019

Neutron direct-geometry time-of-flight chopper spectroscopy is instrumental in studying fundamental excitations of vibrational and/or magnetic origin. We report here that techniques in super-resolution optical imagery (which is in real-space) can be adapted to enhance resolution and reduce noise for a neutron spectroscopy (an instrument for mapping excitations in reciprocal space). The procedure to reconstruct super-resolution energy spectra of phonon density of states relies on a realization of multiframe registration, accurate determination of the energy-dependent point spread function, asymmetric nature of instrument resolution broadening, and iterative reconstructions. Applying these methods to phonon density of states data for a graphite sample demonstrates contrast enhancement, noise reduction, and ∼5-fold improvement over nominal energy resolution. The data were collected at three different incident energies measured at the wide angular-range chopper spectrometer at the Spallation Neutron Source.
Correlations between elastic, calorimetric, and polar properties of ferroelectric PbSc0.5Ta0.5O3 (PST)
Authors: Linyu Gan , Romero Francisco Javier , Franco Victorino , Martín-Olalla José-María , Gallardo María Carmen , Salje Ekhard K. H. , Zhou Yumei , Aktas Oktay
Published: October 2019

Calorimetric, elastic, and polar properties of ferrolectric lead scandium tantalate PbSc0.5Ta0.5O3 with 65% cation order have been investigated in the vicinity of the paraelectric-ferroelectric transition at Ttrans=295 K. Comparison of temperature dependencies of the excess specific heat and elastic properties indicates that both anomalies stem from thermal fluctuations of order parameters in three dimensions. These fluctuations are consistent with the tweed microstructure. This transition is driven by several coupled thermodynamic order parameters, as evidenced by a strongly nonlinear scaling of the excess entropy with the squared ferroelectric polarization.
Large eddy simulations and global stability analyses of an annular and cylindrical rotor/stator cavity limit cycles
Authors: Queguineur Matthieu , Bridel-Bertomeu Thibault , Gicquel Laurent Y. M. , Staffelbach Gabriel
Published: October 2019

Although rotating cavity flows are essential components of industrial applications, their dynamics is still largely misunderstood. From computer hard-drives to turbopumps of space launchers, designed devices often produce flow oscillations that can destroy the component prematurely, or produce disturbing noise or undesired operating modes of the system. The fundamentals of encountered static and rotating flow boundary layers have evidenced, a long time ago now, the presence of specific boundary layer instabilities and structures for low Reynolds numbers. For higher Reynolds numbers and fully enclosed systems, features are, however, more complex with the apparition of multifrequency oscillations populating the entire cavity limit cycle. For these flows, Large Eddy Simulation (LES) has illustrated the capacity of reproducing features and limit cycles. However, identifying the origin and region within these flows that are responsible for mode selections remains difficult if not impossible using such computational fluid dynamics tools. The present contribution evaluates a LES and a global stability analysis framework to identify the mechanisms responsible for the observed limit-cycles of two types of rotor-stator cavities. In particular, the presence of a central body or shaft and its impact on the instability selection is of interest here, i.e., the identification of the regions of mode activation for a cylindrical as well as an annular cavity is detailed. Results issued by the conjunct use of dynamical mode decomposition and Global Linear Stability Analysis (GLSA) confirm the observed LES dynamics. Most importantly, GLSA gives access to the triggering mechanisms at the root of the limit-cycles expression as well as hints on the mode selection. In that respect, a cylindrical cavity is shown to sustain more complex features than an annular cavity because of an enhanced flow curvature near the central shaft.