bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Postoperative Albumin Levels on Furosemide Efficacy in Infants with Congenital Heart Disease
Authors: Aşır Ayşegül , Aldudak Bedri , Matur Okur Nilüfer
Published: December 2024

Postoperative fluid overload is associated with increased mortality and morbidity in infants with congenital heart disease (CHD). Loop diuretics, such as furosemide, are commonly used to prevent fluid overload in the postoperative period. This study aimed to investigate the effect of postoperative albumin levels on the efficacy of furosemide after surgery in infants with CHD. From 1 January 2017 to 31 December 2022, postoperative albumin levels, total furosemide doses, and three-day postoperative diuresis levels were retrospectively analyzed in 186 patients aged 0–1 years who underwent cardiopulmonary bypass at the Pediatric Intensive Care Unit, Diyarbakır Gazi Yaşargil Training and Research Hospital. Demographic and clinical parameters, along with urine output in the first 6 h, first 24 h, 24–48 h, and 48–72 h postoperatively, were recorded. Patients were divided into two groups based on their albumin levels: normal albumin (≥30 g/dL) and hypoalbuminemia (<30 g/dL). A common protein interaction network for albumin and furosemide was constructed using Cytoscape software (version 3.10.2). Of the 186 patients, 79 (42.5%) were male and 107 (57.5%) were female, with a median age of 97.5 days (range 1–360 days). Furosemide doses were higher in hypoalbuminemic patients on postoperative days 1 and 2 compared to normoalbuminemic patients. On postoperative day 1, hypoalbuminemia was more prevalent in patients with oliguria, whereas normoalbuminemia was significantly higher in patients with normouria and polyuria. Furosemide doses were significantly higher in patients with oliguria than in those with normouria in the first 6 h and lower in patients with polyuria compared to those with normouria. A positive correlation was observed between albumin levels and furosemide efficacy on postoperative day 2. Additionally, a positive correlation existed between albumin levels on postoperative day 1 and urine output in the first 6 and 24 h postoperatively. Furosemide efficacy and urine output were positively correlated in the postoperative period. Mortality risk was significantly higher in hypoalbuminemic patients on postoperative days 1 and 2, as well as in patients with oliguria in the first 6 and 24 h postoperatively. Network analysis revealed that albumin was directly involved in furosemide’s target network, along with six other proteins within the common interaction network. Diuresis levels were significantly lower in hypoalbuminemic patients. We suggest that the effectiveness of furosemide is reduced because it cannot bind to albumin at sufficient levels. The effective management of albumin levels may enhance furosemide efficacy and improve postoperative outcomes in infants with CHD.
Liquid Structure of Magnesium Aluminates
Authors: Cristiglio Viviana , Pozdnyakova Irina , Bytchkov Aleksei , Cuello Gabriel J. , Jahn Sandro , Zanghi Didier , Brassamin Séverine , Drewitt James W. E. , Hennet Louis
Published: December 2024

Magnesium aluminates (MgO)x(Al2O3)1−x belong to a class of refractory materials with important applications in glass and glass–ceramic technologies. Typically, these materials are fabricated from high-temperature molten phases. However, due to the difficulties in making measurements at very high temperatures, information on liquid-state structure and properties is limited. In this work, we employed the method of aerodynamic levitation with CO2 laser heating at large scale facilities to study the structure of liquid magnesium aluminates in the system (MgO)x(Al2O3)1−x, with x = 0.33, 0.5, and 0.75, using X-ray and neutron diffraction. We determined the structure factors and corresponding pair distribution functions, providing detailed information on the short-range structural order in the liquid state. The local structures were similar across the range of compositions studied, with average coordination numbers of n¯AlO∼4.5  and n¯MgO∼5.1 and interatomic distances of rAlO=1.76−1.78 Å and rMgO=1.93−1.95 Å. The results are in good agreement with previous molecular dynamics simulations. For the spinel endmember MgAl2O4 (x = 0.5), the average Mg-O and Al-O coordination numbers gave rise to conflicting values for the inversion coefficient χ, indicating that the structural formula used to describe the solid-state order-disorder transition is not applicable in the liquid state.
An Enhanced Bioactive Glass Composition with Improved Thermal Stability and Sinterability
Authors: Martelli Andrea , Bellucci Devis , Cannillo Valeria
Published: December 2024

The development of new bioactive glasses (BGs) with enhanced bioactivity and improved resistance to crystallization is crucial for overcoming the main challenges faced by commercial BGs. Most shaping processes require thermal treatments, which can induce partial crystallization, negatively impacting the biological and mechanical properties of the final product. In this study, we present a novel bioactive glass composition, S53P4_MSK, produced by a melt–quench route. This novel composition includes magnesium and strontium, known for their therapeutic effects, and potassium, recognized for improving the thermal properties of bioactive glasses. The thermal properties were investigated through differential thermal analysis, heating microscopy and sintering tests from 600 °C to 900 °C. These characterizations, combined with X-ray diffraction analysis, demonstrated the high sinterability without crystallization of S53P4_MSK, effectively mitigating related issues. The mechanical properties—elastic modulus, hardness and fracture toughness—were evaluated on the sintered sample by micro-indentation, showing high elastic modulus and hardness. The bioactivity of the novel BG was assessed following Kokubo’s protocol and confirmed by scanning electron microscopy, X-ray energy dispersive spectroscopy, and Raman spectroscopy. The novel bioactive glass composition has shown high sinterability without crystallization at 700 °C, along with good mechanical properties and bioactivity.
Protective Properties of Silane Composite Coatings Modified with Poly(3,4-ethylenedioxythiophene) with Heteropolyacid on X20Cr13 and 41Cr4 Steel
Authors: Kucharczyk-Kotlewska Aleksandra , Adamczyk Lidia , Miecznikowski Krzysztof , Dudek Agata
Published: December 2024

This paper describes the methodology of the preparation and analyses of the structure and anticorrosion properties of silane coatings modified with poly(3,4-ethylenedioxythiophene) (PEDOT) with phosphododecamolybdic acid (PMo12). Protective coatings, consisting of vinyltrimethoxysilane (VTMS), PEDOT powder with PMo12 admixture (at different concentrations), and ethanol, were deposited on X20Cr13 and 41Cr4 steels by immersion. The physicochemical properties of these silane coatings (e.g., surface morphology, thickness, roughness, and adhesion to the substrate) were elucidated using a digital microscope, a Fourier transform infrared spectrophotometer with attenuated total reflectance, and various electrochemical diagnostic techniques. Protective properties were assessed in acidified sulfate solutions with and without chloride ions (pH 2). Experimental results have shown that this coating displayed the effective protection of steel against general and pitting corrosion, stabilized the corrosion potential in the passive state, and provided barrier protection.
The Use of Nanosecond Pulsed Fibre Laser Treatment to Improve the Corrosion Resistance of 316L SS Utilised as Surgical Devices
Authors: Neves Vinicius da Silva , Correa Felipe Queiroz , Ferreira Murilo Oliveira Alves , Rodrigues Alessandro Roger , Wolf Witor , Galo Rodrigo , Yasuoka Fátima Maria Mitsue , Moreto Jéferson Aparecido
Published: December 2024

The nanosecond pulsed fibre laser (NsPFL) treatment is extensively employed to distinguish hospital surgical instruments (micro-surgical forceps, surgical blades, orthopaedic drills, and high-precision laparoscopic tools), which are generally composed of stainless steel. Nevertheless, if the laser parameters are not properly optimised, this process may unintentionally provoke corrosion. Maintaining the structural integrity of these materials is essential for ensuring patient safety and minimising long-term costs. This work aims to optimise the laser scanning parameters for marking 316L stainless steel (316L SS), seeking to improve its corrosion resistance. The corrosion behaviour was assessed by using open circuit potential (OCP), potentiodynamic polarisation curves (PPc), and electrochemical impedance spectroscopy (EIS) techniques, conducted in 0.9% wt NaCl solution at a controlled temperature of 25 ± 1 °C. A comprehensive study employing optical profilometry has significantly enhanced our understanding of the corrosion micromechanisms of 316L SS, comparing specimens both with and without NsPFL treatment. Considering applications involving environments rich in chloride ions, the results indicated that the NsPFL-316L SS samples demonstrated markedly enhanced performance compared to the untreated base material after 48 h of immersion in 0.9% wt NaCl solution. This improvement is particularly noteworthy given the widespread utilisation of 316L SS in the manufacturing of surgical instruments, where corrosion resistance is of paramount importance.
Spin-Density Wave, Unconventional Magnetic and Thermal Transport Properties in Sr2−x(PbCl2)xCu(BO3)2
Authors: Ginting Dianta , Won Bora , Rhyee Jong-Soo
Published: December 2024

SrCu2(BO3)2 (Sr-122) has attracted considerable interest as a quasi-two-dimensional S = 1/2 Heisenberg antiferromagnetic spin system with a Shastry-Sutherland lattice (SSL) structure. It features a Cu2+ spin dimer ground state and exhibits intra-dimer Dzyaloshinskii–Moriya interactions, making Sr-122 a fascinating platform for studying quantum magnetic phenomena. In this study, we investigate the β-phase of SrCu2(BO3)2 (β-Sr-212), which retains the same spin structure as Sr-122, to explore how the carrier concentration affects the spin gap. Our results show that increasing the doping levels in SrCu2(BO3)2 modulates the magnetic properties and slightly suppresses the spin gap, offering new possibilities for tuning its quantum magnetic behavior.
Size Effect on Shear Behaviors of 3D-Printed Soft Rock-like Materials Under Different Shear Velocities
Authors: Wu Chaolei , Jiang Lishuai , Zhao Yang , Wu Qi , Yang Yiming , Peng Xiaohan , Li Pimao
Published: December 2024

The shear failure of rock masses is one of the primary causes of underground engineering instability. The shear mechanical behavior of rocks at different sizes is of great significance for studying the shear failure pattern of engineering rock masses. However, due to the presence of various joints and defects in natural rocks, the obtained rock specimens exhibit significant discreteness, making it difficult to customize specimen sizes for size effect studies. In recent years, 3D printing (3DP) technology has gained widespread application in rock mechanics tests due to its high printing precision and ability to form specimens in a single step with minimal discreteness. Among these, specimens prepared using sand-powder 3DP exhibit elastoplastic mechanical characteristics similar to those of natural rocks. Therefore, this study utilized sand-powder 3DP to prepare rock-like specimens of four different sizes and conducted compression shear tests under three different shear velocities. The shear strength, shear strain, and wear of the shear surfaces were analyzed as functions of specimen size and shear velocities. The results indicate that under the same shear velocity, the shear strength of the specimens is negatively correlated with specimen size. The peak shear strain is generally unaffected by shear velocities, but it increases initially and then decreases with increasing specimen size. As specimen size increases, the degree of specimen damage intensifies, and larger specimens are more prone to developing derived fractures. This study broadens the application of sand-powder 3DP technology in investigating the shear mechanical properties of soft rocks, offering novel insights into the study of size effects in rock mechanics. However, the current research does not encompass tests on 3D-printed rock specimens with varying printing directions, nor does it delve into the role of fractures in size effect analyses. Future investigations will aim to address these limitations, thereby advancing the applicability of 3D printing technology in rock mechanics research and enhancing its contributions to the field.
Study of Process, Microstructure, and Properties of Double-Wire Narrow-Gap Gas Metal Arc Welding Low-Alloy Steel
Authors: Xiao Ning , Kong Haoyu , Sun Qingjie , Ma Ninshu
Published: December 2024

Narrow-gap arc welding is an efficient method that significantly enhances industrial production efficiency and reduces costs. This study investigates the application of low-alloy steel wire EG70-G in narrow-gap gas metal arc welding (GMAW) on thick plates. Experimental observations were made to examine the arc behavior, droplet transition behavior, and weld formation characteristics of double-wire welding under various process parameters. Additionally, the temperature field of the welding process was simulated using finite element software (ABAQUS 2020). Finally, the microstructure and microhardness of the fusion zone in a double-wire, single-pass filled joint under the different welding speeds were compared and analyzed. The results demonstrate that the use of double-wire GMAW in narrow-gap welding yielded positive outcomes. Optimal settings for wire feeding speed, welding speed, and double-wire lateral spacing significantly enhanced welding quality, effectively preventing side wall non-fusion and poor weld profiles in the welded joints. The microstructure of the fusion zone produced at a higher welding speed (11 mm/s) was finer, resulting in increased microhardness compared to welds obtained at a lower speed (8 mm/s). This is attributed to the shorter duration of the liquid molten pool and the faster cooling rate associated with higher welding speed. This research provides a reference for the practical application of double-wire narrow-gap gas metal arc welding technology.
Evaluation of Recycled and Reused Metal Powders for DMLS 3D Printing
Authors: Svozilova Simona , Zetková Ivana , Marin Juan Felipe Santa , Garay Jesús Arturo Torres
Published: December 2024

Metal powders for additive manufacturing are expensive, and producing new ones from mined metals has a negative ecological impact. In this work, recycled and reused metal powders from MS1 steel for direct metal laser sintering (DMLS) 3D printing were evaluated in the laboratory. The powders were recycled by melting followed by gas atomizing. Virgin, recycled, and reused metal powders were evaluated using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), metallography analysis, microhardness measurements, particle size distribution (PSD), shape factor by digital image processing (DIP), and flowability testing. The results showed that the particle distribution was modified after recycling. Kurtosis analysis revealed a reduction from −0.64 for virgin powders to −1.29 for recycled powders. The results demonstrated a positive skewness, indicating that the recycled powder contained a greater proportion of smaller particles. The shape factor was also modified and changed from 1.57 for virgin powders to 1.28 for recycled powders. The microstructure also changed, and austenite was found in the recycled powders. The microhardness of recycled powder decreased by 39% compared to the virgin powder. Recycled powders did not flow, using two different funnels to evaluate their flowability. The flowability of used powder was reduced from 4.3 s to 2.9 s.
Application of Powder-Bed Fusion of Metals Using a Laser for Manufacturing of M300 Maraging Steel Tools Intended for Sheet Metal Bending
Authors: Żaba Krzysztof , Balcerzak Maciej , Kuczek Łukasz , Wiewióra Marcel , Różycka Ilona , Trzepieciński Tomasz , Mizera Jarosław
Published: December 2024

This paper presents the results of a pilot application of Powder-Bed Fusion of Metals Using a Laser (PBF-LB/M) for the fabrication of M300 (1.2709) maraging steel sheet metal bending tools. S235 steel was used as a substrate for the fabrication of bending punches. The main goal of the research was to determine the usability of such tools without heat treatment, which would contribute to the increase in the cost of tool production. Industrial tests of tools were conducted during the forming of Inconel 625 and AW-6061 T0 aluminium alloy sheets. The punches were subjected to tests of surface roughness, hardness, microstructure, porosity, and geometric quality in order to verify the quality and accuracy of tools made by the PBF-LB/M technique before and after experimental investigations in industrial conditions in a selected manufacturing company. It was found that tools with an M300 steel working layer after the PBF-LB/M process without heat treatment show suitability for bending sheet metal in a certain range of force parameters, ensuring obtaining elements after bending from Inconel 625 and AW-6061 T0 aluminium alloy sheets of the required geometric quality.
Unveiling the Potential of Civil Briquette Furnace Slag as a Silico–Aluminon Additive in Alkali-Activated Materials
Authors: Ren Suoying , Li Liang , Zhao Xianhui , Wang Haoyu , Zhao Renlong
Published: December 2024

Civil briquette furnace slag (FS), as a type of industrial solid waste, is not currently being recycled as a resource by the building materials industry. This study focuses on the potential of FS in the formulation of alkali-activated materials (AAMs) compared with calcium carbide slag (CS). This study encompasses three distinct AAM systems: alkali-activated fly ash alone (AAFA), fly ash–slag powder blends (AAFB), and slag powder alone (AABS). Electrical conductivity, fluidity, drying shrinkage, and flexural and compressive strengths were also assessed. Advanced characterization techniques, including SEM-EDS, XRD, FTIR, and TG-DSC, were utilized to examine the morphology, mineralogy, and reaction products. Despite the chemical similarity between FS and CS, FS exhibits limited active chemical components (SiO2, Al2O3, CaO, and MgO) and primarily functions as a physical filler, and thus lacks the chemical binding properties of CS. FS has a positive effect on the long-term compressive strength of the AABS system but not on the AAFA and AAFB systems. The NaOH-activated SP mortar sample with 20% FS reaches a compressive strength of 29.8 MPa at 360 days. The binding strength in AAMs incorporating FS is predominantly attributed to the gel formation within the alkali-activated matrix. This research offers valuable insights into the strategic use and substitution of CS, FS, and other silico–aluminon additives within the context of AAMs development.
Mechanical Behavior of 3D-Printed Zig-Zag Honeycomb Structures Made of BASF Ultrafuse 316L
Authors: Sarzyński Marcin , Płatek Paweł , Cedro Patryk , Gunputh Urvashi , Wood Paul , Rusinek Alexis
Published: December 2024

The aim of this study is to determine the mechanical behavior of 2D honeycomb cellular structures with deformation initiators subject to quasi-static compression testing. Two different loading directions were studied: in-plane (IP) and out-of-plane (OP). The deformation initiators sought to stabilize the mechanical response by decreasing the initial peak force in the case of OP loading. The samples for testing were made using stainless steel 316L that was 3D-printed using material extrusion (MEX). The method enables fabrication of structures with high mechanical strength and ductility. The findings of the quasi-static compression testing showed that the additional deformation initiators were able to significantly reduce the orthotropy in the mechanical response of honeycomb cellular structures.
Flexural Behavior of BFRP Bar–Recycled Tire Steel Fiber-Reinforced Concrete Beams
Authors: Fu Jing-Hua , Zhang Ao , Chen Kai-Feng , Li Bao-Yuan , Wu Wei
Published: December 2024

This research advocates for the use of basalt fiber-reinforced polymer (BFRP) bars and recycled tire steel fibers to reinforce concrete beams. Six concrete beams were constructed using different volume contents of recycled tire steel fibers (0, 0.5%, 1.0%, 1.5%) and BFRP reinforcement ratios (0.48%, 0.75%, 1.08%). Mechanical properties tests were conducted to investigate the flexural characteristics and failure modes of beams utilizing the non-contact full-field strain displacement measuring technology–digital image (3D-DIC) technology. The recycled tire steel fiber (RTSF) improves flexural performance, which contributes to inhibiting crack propagation, reducing flexural deformation, and improving the first cracking and ultimate loading capacities. Under the same reinforcement ratio, in comparison to ordinary BFRP beams, the cracking load of BFRP-RTSF beams increased by 17.73%, 23.76%, and 42.94%, respectively, and the ultimate bearing capacity increased by 4.03%, 5.85%, and 13.21%, respectively. In addition, a modified calculation model of bearing capacity considering RTSF tensile strength is proposed. The predicted values of BFRP-RTSF beams match well with the experimental values.
Anti-Inflammatory Properties of Novel 1,2-Benzothiazine Derivatives and Their Interaction with Phospholipid Model Membranes
Authors: Szczęśniak-Sięga Berenika M. , Maniewska Jadwiga , Wiatrak Benita , Janek Tomasz , Nowotarska Paulina , Czyżnikowska Żaneta
Published: December 2024

The design of novel anti-inflammatory drugs remains a critical area of research in the development of effective treatments for inflammatory diseases. In this study, a series of 1,2-benzothiazine was evaluated through a multifaceted approach. In particular, we investigated the potential interactions of the potential drugs with lipid bilayers, an important consideration for membrane permeability and overall pharmacokinetics. In addition, we evaluated their ability to inhibit cyclooxygenase 1 and cyclooxygenase 2 activity and selectivity using both a cyclooxygenase inhibition assay and molecular docking simulations. To evaluate their therapeutic potential, we performed in vitro assays to measure cytokine mRNA expression in inflamed cells. The antioxidant activity was evaluated using both in vitro assays, such as 2,2-diphenyl-1-picrylhydrazyl and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid scavenging, to determine the compounds’ capacity to neutralize free radicals and reduce oxidative stress. Theoretical calculations, including density functional theory, were used to predict the reactivity profiles of the compounds.
Effects of Medium and Flow Rate on the Film-Forming Structures of B10 Cu-Ni Alloys and Their Resistance to Corrosion Caused by Sulfate-Reducing Bacteria
Authors: Lu Bochao , Cui Ning , Zhang Yimeng , Guo Ding , Wang Yanan , Wang Xiaopeng , Duan Jizhou
Published: December 2024

The effects of medium and flow rate on the film-forming structures of B10 Cu-Ni alloys and their resistance to corrosion caused by sulfate-reducing bacteria are investigated in this article. Combined with a predicted cloud map of pipeline corrosion area and a particle motion trajectory map obtained using Computational Fluid Dynamics (CFD), the growth law of alloy passivation films was analyzed and the pitting process of sulfate-reducing bacteria (SRB) on passivation films was revealed. The results show that the film formation effect is best when the stream of water in the film-forming environment is filtered seawater with a flow rate of 0.8 m/s, which consists of a uniform and dense gray-brown passivated film layer with the strongest resistance to SRB corrosion. When the flow rate is 0 m/s, the clay particles in the seawater cover the surface of the passivation film, hindering the contact of oxygen with the substrate and inhibiting the growth of the passivation film. When the stream of water in the film-forming environment is seawater with a flow rate of 3 m/s, the surface of the substrate shows obvious scouring marks, which is favorable for the enrichment of SRB and further accelerates the pitting corrosion of the substrate. Cl− has a significant influence on the formation of passivation films on B10 Cu-Ni alloys. When the filming medium is deionized water, the B10 Cu-Ni alloy does not form a complete passivation film at all flow rates.
PET-PZT Dielectric Polarization: Electricity Harvested from Photon Energy
Authors: Nikolov Alex , Murad Sohail , Lee Jongju
Published: December 2024

The effect of residual stress or heat on ferroelectrics used to convert photons into electricity was investigated. The data analysis reveals that when the PET-PZT piezoelectric transducer is UV-irradiated with a 405 nm wavelength, it becomes a photon–heat–stress electric energy converter and capacitator. Our objective was to evaluate the PET-PZT photon–heat–stress electric energy conversion performance and the role of the light’s wavelength and intensity. Converting waste energy from energy-intensive processes and systems is crucial to reducing the environmental impact and achieving net-zero emissions. To achieve these, innovative materials are needed to efficiently convert ambient energy into electricity through various physical mechanisms, such as the photovoltaic effect, thermoelectricity, piezoelectricity, triboelectricity, and radiofrequency wireless power transfer.
Cost-Effective Bioimpedance Spectroscopy System for Monitoring Syncytialization In Vitro: Experimental and Numerical Validation of BeWo Cell Fusion
Authors: Saadé Karim , Hussain Mohammed Areeb , Bainbridge Shannon A. , St-Gelais Raphael , Variola Fabio , Fenech Marianne
Published: December 2024

The placenta plays a critical role in nutrient and oxygen exchange during pregnancy, yet the effects of medicinal drugs on this selective barrier remain poorly understood. To overcome this, this study presents a cost-effective bioimpedance spectroscopy (BIS) system to assess tight junction integrity and monolayer formation in BeWo b30 cells, a widely used model of the multinucleated maternal–fetal exchange surface of the placental barrier. Cells were cultured on collagen-coated porous membranes and treated with forskolin to induce controlled syncytialization. Electrical impedance was measured using an entry level impedance analyzer, while immunofluorescence staining was used to confirm monolayer formation and syncytialization. The measurements and staining confirmed the formation of a confluent monolayer on day 4. In fact, the electrical resistance tripled for treated samples indicating a more electrically restrictive barrier. This resistance remained constant for treated samples reflecting the intact barrier’s integrity over the next 3 days. The measurements show that, on day 4, the electrical capacitance of the cells decreased for the treated samples as opposed to the untreated samples. This reflects that the surface area of the BeWo b30 cells decreased when the samples were treated with forskolin. Finally, a COMSOL model was developed to explore the effects of electrode positioning, depth, and distance on TEER measurements, explaining discrepancies in the literature. In fact, there was a substantial 97% and 39.4% difference in the obtained TEER values. This study demonstrates the AD2 device’s feasibility for monitoring placental barrier integrity and emphasizes the need for standardized setups for comparable results. The system can hence be used to analyze drug effects and nutrient transfer across the placental barrier.
A Selective Electrochemical Sensor for Bisphenol A Detection Based on Cadmium (II) (bromophenyl)porphyrin and Gold Nanoparticles
Authors: Rejab Fatma , Dardouri Nour Elhouda , Rouis Ahlem , Echabaane Mosaab , Nasri Habib , Lakard Boris , Ben Halima Hamdi , Jaffrezic-Renault Nicole
Published: December 2024

Bisphenol A (BPA) is a commonly synthetic chemical mainly used in producing plastic items. It is an endocrine-disrupting compound that causes irreversible health and environmental damage. Developing a simple method for BPA effective quantitative monitoring is emergently necessary. Herein, a novel electrochemical sensor for BPA detection based on [(5,10,15,20-tetrakis(p-bromophenyl) porphyrinato] cadmium (II) [(CdTBrPP)] and gold nanoparticle (AuNPs)-modified screen-printed carbon electrode (SPCE) was elaborated. CdTBrPP was synthesized and then characterized with Ultraviolet–Visible Spectroscopy (UV/vis), Infrared Spectroscopy (IR), and Proton Nuclear Magnetic Resonance Spectroscopy (1H NMR) to confirm its successful synthesis. After drop-coating AuNPs and CdTBrPP on the SPCE, the sensor performance was evaluated using square wave voltammetry (SWV), a linear response in a concentration range from 10−11 M to 10−2 M, with a low detection limit (LOD) of 9.5 pM. The CdTBrPP/AuNPs/SPCE sensor demonstrates a high selectivity and reproducibility, making it a promising candidate for developing a low-cost water-monitoring system for detecting BPA. Additionally, the proposed sensor effectively detected BPA in both tap and mineral water samples.
Biosensors for Seafood Safety Control—A Review
Authors: Trinh Thi Ngoc Diep , Nguyen Hanh An , Thi Nguyen Pham Anh , Nam Nguyen Nhat , Tran Nguyen Khoi Song , Trinh Kieu The Loan
Published: December 2024

The increased demand for consuming seafood has made seafood production undergo a rapid period of growth. However, seafood has a high risk of contamination from harmful microorganisms and marine toxins which can cause health problems for humans consuming it. Concerning this issue, monitoring seafood safety has become a center of attention for researchers, and developing effective methods for detecting contamination in seafood has become a critical research field. In this context, biosensors have served as a promising approach to monitor seafood contamination. Compared to conventional methods, biosensors have some key benefits such as high sensitivity, selectivity, portability, and user-friendly operation. Along with significant advances in biosensors, processes of seafood monitoring can be simplified and performed outside the laboratory. In this review article, we describe the mechanisms of two main types of biosensors regarding electrochemical and optical biosensors. The current reports within the last five years on the application of these biosensors for seafood monitoring are also summarized.
Case Studies of Magnetic and Electromagnetic Techniques Covering the Last Fifteen Years
Authors: Vallée Marc A. , Moussaoui Mouhamed , Khan Khorram
Published: December 2024

Magnetic and electromagnetic techniques have a long history of application in mineral exploration to detect deposits and their surroundings. Their implementation over the last fifteen years has been affected by strong variations in the mining market in parallel with important technological developments. During this period, both methods were the subject of numerous documented case studies all over the globe, which is a sign of popularity and longevity of these techniques. Through a review of case histories from the main geophysical journals, we analyze the principal usage of these methods when applied to mineral exploration, while the majority of documented cases originate from North America, Asia, and Australia. There are more case studies describing the use of the magnetic method and we attribute this popularity to direct and indirect use of this method for mineral exploration. In particular, there is an increasing number of magnetic surveys conducted with drones. Combining magnetic and electromagnetic techniques is also common. The number of magnetic and EM technique case histories range by descending order from gold, porphyry copper, polymetallic, massive sulfides, uranium, Ni-Cu-PGE, iron ore, kimberlite, and iron-oxide copper-gold, with a number of single continent-specific applications.
First-Principle Calculations on O-Doped Hexagonal Boron Nitride (H-BN) for Carbon Dioxide (CO2) Reduction into C1 Products
Authors: Liu Guoliang
Published: December 2024

With the rapid growth of the world population and economy, the greenhouse effect caused by CO2 emissions is becoming more and more serious. To achieve the “two-carbon” goal as soon as possible, the carbon dioxide reduction reaction is one of the most promising strategies due to its economic and environmental friendliness. As an analog of graphene, monolayer h-BN is considered to be a potential catalyst. To systematically and theoretically study the effect of O doping on the CO2 reduction catalytic properties of monolayer h-BN, we have perform a series of first-principle calculations in this paper. The structural analysis demonstrates that O preferentially replaces N, leading to decreasing VBM of monolayer h-BN, which is conducive to improving its capability for CO2 reduction. The preferential CO2 adsorption sites on monolayer h-BN before and after O doping are the N-t site and B-t site, respectively. O doping increases the adsorption strength of CO2, which is favorable in the further hydrogenation of CO2. During the conversion of CO2 into CO and HCOOH via a two-electron pathway and CH3OH and CH4 via a six-electron pathway, O doping can reduce the energy barrier of the rate determining step (RDS) and change the key steps from uphill reactions to downhill reactions, thus increasing the probability of CO2 reduction. In conclusion, O(N)-doped h-BN exhibits the excellent CO2 reduction performance and has the potential to be a promising catalyst.
Chemical Bonding and Dynamic Structural Fluxionality of a Boron-Based B8Al3+ Cluster
Authors: Gao Shu-Juan , Yu Tan-Lai
Published: December 2024

We studied the boron-based composite cluster B8Al3+ doped with Al atoms. The global minimum structure of the B8Al3+ cluster is a three-layer structure, consisting of three parts: an Al2 unit, a B8 ring and an isolated Al atom. Charge calculations analysis shows that the cluster can be expressed as [Al]+[B8]2−[Al2]2+, has 6π/6σ double aromaticity and follows the (4n+2) Hückel rule. Born–Oppenheimer molecular dynamics (BOMD) simulation shows that the B8Al3+ cluster has dynamic fluxionality properties. Remarkably, at the single-point coupled cluster singles, doubles and triples (CCSD(T)) level, the energy barrier for intramolecular rotation is merely 0.19 kcal mol−1. [B8]2− molecular wheels have magical 6π/6σ double aromaticity properties, providing a continuous cloud of delocalized electrons, which is a key factor in the dynamic fluxionality of the cluster. The B8Al3+ cluster provides a new example of dynamic structural fluxionality in molecular systems.
Designing and Optimizing Electrode Materials for Energy Harvesting in CAPMIX Cells
Authors: Lobato Belén , Flores Samantha L. , dos Santos-Gómez Lucía , García Ana B. , Pernía Alberto M. , Prieto Miguel J. , Busto María G. , Arenillas Ana
Published: December 2024

The growing demand for clean, decentralized energy has increased interest in blue energy, which generates power from water with different salt concentrations. Despite its potential as a renewable, low-cost energy source, optimizing electrode materials remains a challenge. This work presents a nanomaterial developed via microwave-assisted sol-gel methodology for blue energy applications, where ion diffusion and charge storage are critical. AX-7 carbon, designed for this study, features wide pores, enhancing ion diffusion. Compared to commercial NORIT carbon, AX-7 has a higher mesopore volume and external surface area, improving its overall performance. The synthesis process has been optimized and scaled up for evaluation in CAPMIX electrochemical cell stacks. Moreover, the lower series resistance (Rs) significantly boosts energy recovery, with AX-7 demonstrating superior performance. This advantage is especially evident during fresh-water cycles, where this material achieves significantly lower Rs compared to the commercial one.
The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review
Authors: Cotoia Antonella , Charitos Ioannis Alexandros , Corriero Alberto , Tamburrano Stefania , Cinnella Gilda
Published: December 2024

Traumatic brain injury (TBI) represents a multifaceted pathological condition resulting from external forces that disrupt neuronal integrity and function. This narrative review explores the intricate relationship between dietary macronutrients, gut microbiota (GM), and neuroinflammation in the TBI. We delineate the dual aspects of TBI: the immediate mechanical damage (primary injury) and the subsequent biological processes (secondary injury) that exacerbate neuronal damage. Dysregulation of the gut–brain axis emerges as a critical factor in the neuroinflammatory response, emphasizing the role of the GM in mediating immune responses. Recent evidence indicates that specific macronutrients, including lipids, proteins, and probiotics, can influence microbiota composition and in turn modulate neuroinflammation. Moreover, specialized dietary interventions may promote resilience against secondary insults and support neurological recovery post-TBI. This review aims to synthesize the current preclinical and clinical evidence on the potential of dietary strategies in mitigating neuroinflammatory pathways, suggesting that targeted nutrition and gut health optimization could serve as promising therapeutic modalities in TBI management.
Vitamin D Status in Roma Mothers and Newborns: Socioeconomic Factors and Impact on Neonatal Outcome
Authors: Stoica Andreea Bianca , Săsăran Maria Oana , Suciu Laura Mihaela , Huțanu Adina , Mărginean Claudiu
Published: December 2024

Background: The Roma are a socioeconomically disadvantaged, marginalized community with reduced access to education, social services, and healthcare. Despite the known health risks they are exposed to, we have limited data about a wide range of health outcomes in this population, including vitamin D deficiency. The aim of this study was to investigate prevalence of vitamin D deficiency and its impact on the anthropometric outcomes of newborns in a group of Roma mothers and their infants in Romania. Methods: In total, 131 Roma women and 131 newborns were included in the study. Vitamin D levels in both mothers and newborns, as well as the birth weight, length, and head circumference of newborns, were recorded at birth. We also assessed socioeconomic factors, including education, employment status, income, and living conditions, as well as factors that influence vitamin D status, including sun exposure, use of sunscreen, fish consumption, and skin type. Results: All mothers and almost all newborns had vitamin D insufficiency or deficiency, with 25-hydroxivitamin D levels below 30 ng/mL. Maternal vitamin D status was significantly correlated with neonatal vitamin D levels (p < 0.01) but not with anthropometric outcomes such as birth weight (p = 0.57), birth length (p = 0.53), or head circumference (p = 0.96). Most study participants had a low socioeconomic status, reporting severe deficiencies in education, employment status, household income, and living conditions. Conclusions: Vitamin D deficiency is a significant public health issue among Roma women and their newborns, which may be compounded by the socioeconomic challenges of this vulnerable population.
Targeting the Calcium-Sensing Receptor in Chemically Induced Medium-Grade Colitis in Female BALB/C Mice
Authors: Piatek Karina , Gushchina Valeriya , Kleinwächter Ava , Kupper Nadja , Mesteri Ildiko , Elajnaf Taha , Iamartino Luca , Salzmann Martina , Müller Christian , Manhardt Teresa , Vlasaty Andrea , Kallay Enikö , Schepelmann Martin
Published: December 2024

Background/Objectives: The extracellular calcium-sensing receptor (CaSR) is a multifunctional receptor proposed as a possible drug target for inflammatory bowel disease. We showed previously that CaSR inhibition with NPS 2143, a negative allosteric modulator of the CaSR, somewhat ameliorated the symptoms of chemically induced severe colitis in mice. However, it was unclear whether the potential of CaSR inhibition to reduce colitis may have been overshadowed by the severity of the induced inflammation in our previous study. Therefore, we tested if CaSR inhibition could prevent medium-grade colitis. Methods: Female BALB/c mice were treated with NPS 2143 or a vehicle prior to the induction of colitis with 2.5% DSS. On the day of sacrifice, colons and plasma were collected. The histology score was determined based on hematoxylin-eosin-stained sections. Mucin content, proliferation (Ki67), and immune cell infiltration (CD3 and CD20) were quantified based on immunostainings. Gene expression was measured by RT-qPCR. Results: Treatment with NPS 2143 had no effect on the clinical symptom score of the mice. However, the colons of the mice in the treated group were significantly longer (p < 0.05), and NPS 2143 significantly reduced colon ulceration (p < 0.05). The treatment also significantly reduced the expression of COX2 in the proximal colon and IL-22 in the distal colon. The proliferation of cells in the lymph nodes was significantly lower after the treatment, but no difference was observed in the epithelial cells. Conclusions: In summary, while NPS 2143 had an anti-inflammatory effect on medium-grade colitis, this effect appeared to be milder than in severe colitis, as observed previously, indicating that the effectiveness of CaSR inhibition as an anti-inflammatory measure in the colon is proportional to disease severity.
Label Accuracy and Quality of Select Weight-Loss Dietary Supplements Sold on or near US Military Bases
Authors: Crawford Cindy , Lindsey Andrea T. , Avula Bharathi , Katragunta Kumar , Khan Ikhlas A. , Deuster Patricia A.
Published: December 2024

Background/Objectives: Sixty-eight percent of service members are living with overweight or obesity, some who may not consult a healthcare provider when they decide to lose weight. Instead, they often turn to weight-loss dietary supplements for self-care solutions. The purpose of this case series study was to examine the label accuracy and quality of select weight-loss dietary supplements sold on or near US military bases across the country. Methods: Weight-loss dietary supplements (n = 44) were selected and purchased in GNCs, Exchanges, and Shoppettes across 12 military installations from March 2023 to January 2024. Liquid chromatography-mass spectrometry was used to verify the label accuracy according to the Supplement Facts listed ingredients and whether they contained any ingredients prohibited for use in the military. Product label claims were analyzed using the Operation Supplement Safety (OPSS) Risk Assessment Scorecard. Results: Thirty-six products (82%) had inaccurate labels. Twenty-seven (61%) had ingredients listed on the label not detected through analysis. Sixteen products (36%) contained hidden ingredients. The four products purchased within one mile from the base listed multiple prohibited ingredients on the labels, with all detected. Forty (91%) products scored a “no-go” according to the OPSS Scorecard and none contained a third-party certification seal on the label. Multiple stimulants were included in products such that the product safety was unknown. Conclusions: The majority of weight-loss dietary supplements analyzed in this case series study had inaccurate labels and were considered a “no-go” according to the Scorecard. Service members should only have access to safe, high-quality dietary supplement products. OPSS is collaborating with the Department of Defense stakeholders to determine the most effective ways for service members to have access to third-party certified products on all military establishments.
Tailored Multifaceted Strategy for Implementing Fundamental Evidence-Based Nursing Care: An Evaluation Study
Authors: Eekholm Signe , Samuelson Karin , Ahlström Gerd , Lindhardt Tove
Published: December 2024

Background/Objectives: Extensive research has emphasised the persistent challenges and failures in providing hospitalised patients with fundamental evidence-based nursing care, often resulting in grave consequences for patient safety. Recommendations from implementation research indicate that a tailored theory- and research-based implementation strategy targeting contextual determinants can optimise the implementation of evidence-based clinical practice for the benefit of patients. This study evaluated the feasibility of an implementation strategy designed to improve the quality of nursing care by targeting behavioural and environmental barriers in a hospital setting. Methods: Proctor’s conceptual model for implementation was applied to evaluate the strategy based on eight outcomes: adoption, acceptability, appropriateness, fidelity, feasibility, penetration, sustainability, and costs. Data collection methods included field observations, informal and focus group interviews, registrations, and audits of electronic patient records. Results: The strategy was adoptive, acceptable, appropriate, and feasible in targeting complex environmental and behavioural determinants (at the individual, team, and management level), enabling successful implementation of fundamental evidence-based nursing care. However, fidelity, feasibility, and sustainability were challenged by competing organisational demands and time constraints. Conclusions: The tailored, multifaceted strategy proved effective in addressing complex environmental and behavioural determinants across multiple levels, facilitating the implementation of fundamental evidence-based nursing care in a clinical practice. Further testing and larger-scale studies is needed to assess the strategy’s transferability and its impact on nursing-sensitive patient outcomes in different clinical settings.
Serosurvey of Rickettsia spp. and Ehrlichia canis in Dogs from Shelters in Sicily (Southern Italy)
Authors: Di Bella Santina , Gambino Delia , Pepe Davide , Gentile Antonino , Blanda Valeria , Valenti Antonio , Santangelo Francesco , Ballatore Antonino , Spina Giuseppe , Barbaccia Giuseppe , Cannella Vincenza , Cassata Giovanni , Guercio Annalisa
Published: December 2024

Vector-borne diseases represent a serious threat to human and animal health, especially where environmental conditions favor pathogen-carrying vectors. Dogs serve as natural hosts for two tick-borne pathogens: Ehrlichia canis, which causes canine monocytic ehrlichiosis, and spotted fever group (SFG) Rickettsia spp., a zoonotic threat in the Mediterranean region. Rhipicephalus sanguineus is the primary vector for these pathogens. Shelter dogs, due to increased exposure to ticks and confined living conditions, facilitate the spread of vector-borne pathogens, raising the risk of zoonotic transmission. This study conducted a serological survey of 1287 dogs from two shelters, assessing exposure to Rickettsia spp. and E. canis and examining the influence of demographic and environmental factors. Seroprevalence rates were 41.8% for Rickettsia spp. and 24.5% for E. canis, with 14% of dogs positive for both pathogens. No significant association was found with sex or breed. A higher seroprevalence was observed in dogs older than 12 months and in those from the shelter on the Mediterranean coast compared to those from the Tyrrhenian coast, likely due to climatic differences. The study highlights the role of climate in disease spread and the need for public health interventions, supporting One Health initiatives to prevent zoonotic disease transmission.