bluuebunny/crossref_metadata_2025 huggingface dataset:
Efeitos e Dilemas da Violência na Produção de Cuidado nas Estratégias de Saúde da Família
Authors: Martins André Amorim , Martins Vitória Silva , Aparecida Elias D´  Alessandro Josiane
Published: May 2023

A violência engloba vários fatores e se caracteriza como um grande desafio para trabalhadores da área da saúde. No âmbito da gestão em saúde, o Ministério da Saúde define a Ficha de Notificação de Violências e Agravos como um instrumento de uso compulsório por parte dos profissionais da área, para mapeamento de casos e criação de estratégias de atuação. Este estudo buscou analisar, por meio de Grupos Focais com equipes de Estratégia de Saúde da Família, a temática da violência aliada ao preenchimento das Fichas de Notificação. Os resultados da pesquisa apontam para a subnotificação de casos de violência e dilemas éticos em torno do preenchimento, fatos que prejudicam de forma substancial a produção do cuidado pelas equipes. Portanto, vislumbra-se que as equipes de Estratégia de Saúde da Família necessitam de capacitação e compreensão sobre a intersetorialidade nas ações sobre violências.
Atuação de Psicólogas Clínicas Perante o Sofrimento Psíquico Originado pelo Racismo
Authors: Santos Felipe Barbosa dos , Castelar Marilda , Machado Veridiana Silva , Lisboa Milena Silva , Souto Verena Souza
Published: May 2023

Introdução: Segundo seu código de ética, as profissionais de psicologia devem combater qualquer tipo de violência e discriminação, dessa forma, reconhecendo o racismo como determinante na saúde. O estudo objetivou analisar a atuação de psicólogas clínicas de Salvador perante o racismo e a demanda de atendimento fruto do racismo. Métodos: Trata-se de uma pesquisa qualitativa, descritiva e exploratória. Foram analisadas seis entrevistas com psicólogas de Salvador que se autoidentificaram como negras/os e trabalham com relações raciais. Resultados: Os resultados demonstram que o racismo aparece na atuação clínica, em demanda primária ou associada a um outro estado de sofrimento. Discussões e Conclusões: Após a identificação, existe uma preocupação em potencializar as formas de elaboração desse sofrimento específico. Os dados podem contribuir para o exercício em psicologia perante o sofrimento psíquico originado pelo racismo.
Impact of Portal Vein Thrombosis on the Outcomes of Liver Transplantation
Authors: EREN Eryigit , DİNÇKAN Ayhan
Published: May 2023

Portal vein thrombosis (PVT) occurs in up to 17.9% of patients awaiting liver transplantation. It may impact post-liver transplantation survival negatively. The liver transplant procedures performed in our transplant center between January 2020 and June 2021 were screened. Data were collected retrospectively from the electronic folder system. Data, including causes of mortality, recipient gender, age, transplant indication, presence of hepatocellular carcinoma, rejection episodes, number of days in the intensive care unit, hospitalization duration, and complications, were recorded. Patients with no PVT constituted the control group. Patients with PVT were considered as the study group. Student’s t-test and the Mann-Whitney U test were used to evaluate the significance of the difference between study groups. Overall, 223 liver transplants were performed within the study period. Three re-transplants were excluded from the study. The analysis of 220 liver transplant patients revealed that 18.2% (n=20) of the patients presented with a PVT before liver transplantation. Patients with PVT had a higher rate of non-alcoholic steatohepatitis as an indication of a liver transplant. In addition, the presence of PVT significantly increased surgical mortality and early rejection rates. In correlation with this, the intensive care unit stay was longer in the patient group with PVT. Although the early surgical mortality post-liver transplant was higher in the group with PVT, the underlying variables could not be identified in this study. Nevertheless, the late mortality rates were not higher in patients with PVT following liver transplantation
The possible role of gut microbiota dysbiosis in the pathophysiology of delirium in older persons
Authors: Ticinesi Andrea , Parise Alberto , Nouvenne Antonio , Cerundolo Nicoletta , Prati Beatrice , Meschi Tiziana
Published: May 2023

Delirium is a clinical syndrome characterized by an acute change in attention, awareness and cognition with fluctuating course, frequently observed in older patients during hospitalization for acute medical illness or after surgery. Its pathogenesis is multifactorial and still not completely understood, but there is general consensus on the fact that it results from the interaction between an underlying predisposition, such as neurodegenerative diseases, and an acute stressor acting as a trigger, such as infection or anesthesia. Alterations in brain insulin sensitivity and metabolic function, increased blood-brain barrier permeability, neurotransmitter imbalances, abnormal microglial activation and neuroinflammation have all been involved in the pathophysiology of delirium. Interestingly, all these mechanisms can be regulated by the gut microbiota, as demonstrated in experimental studies investigating the microbiota-gut-brain axis in dementia. Aging is also associated with profound changes in gut microbiota composition and functions, which can influence several aspects of disease pathophysiology in the host. This review provides an overview of the emerging evidence linking age-related gut microbiota dysbiosis with delirium, opening new perspectives for the microbiota as a possible target of interventions aimed at delirium prevention and treatment.
An enigmatic term of ‘bean-counter’: A changing phenomenon in Indonesia’s accountant
Authors: Hermawan Marko S , Silalahi Ayuphita Tiara
Published: May 2023

The term 'bean-counter' came from the image of an accountant that has a boring, dull, and colorless life. This stereotyping could lead to a negative association with the accounting profession. Nevertheless, only some countries worldwide have the same perception of the accountant image profession. The study attempts to investigate Indonesian accounting graduates in the productive age group towards being an accountant. A qualitative data collection that measures distinct leader, manager and professional roles preference is used, with a semi-structured interview in three diverse perspectives from the accounting students, accounting graduates, and accounting professionals. The findings suggest that there is no perception of an accountant as a bland and colorless life job; rather, they realize that accounting is more than bookkeeping and tracking numbers. Accountants nowadays need to be creative, and the job is quite challenging from this millennial’s point of view.
Integração Regional, Política Externa e Relações Executivo/Legislativo: Presidencialismo versus Parlamentarismo: O Uruguai no Mercosul e o Reino Unido na União Europeia
Authors: De Almeida Medeiros Marcelo , De Araújo Ramos Maria Regina , Coêlho de Souza Oliveira Natália
Published: May 2023

Os diferentes arranjos institucionais do Uruguai e do Reino Unido importam para as tomadas de decisões sobre os processos de integração regional? Este estudo compara os casos para identificar os fatores que levaram à estabilidade uruguaia no Mercosul e à saída britânica da União Europeia. Os dados mostram que Westminster foi um facilitador para que o Brexit ocorresse, enquanto o presidencialismo Uruguaio poderia dificultar uma barganha parecida no Mercosul.
O Terceiro Mundo encontra os direitos humanos: a Conferência de Teerã de 1968 revisitada
Authors: Roriz João
Published: May 2023

O artigo argumenta que a Conferência de Teerã foi um marco na prática discursiva anti-colonial dos direitos humanos construída por diplomatas do terceiro mundo. Baseado em pesquisa documental e em literatura pós-colonial, o artigo mostra as ambivalências da conferência, com novos enquadramentos de direitos humanos e envolvimento de regimes autoritários. Denúncias contra a colonização e racismo apareceram a partir da linguagem dos direitos humanos, assim como a pauta do desenvolvimento.
Responsive governance: an approach to the conservation and sustainable use of Biodiversity Beyond National Jurisdiction
Authors: Gonçalves Leandra Regina
Published: May 2023

Marine areas beyond national jurisdiction represent 64% of the total surface area of the oceans and around half of the planet's total surface area. Through their remoteness and vast expanse, they were largely protected from human interference in the past. However, technological advances have removed this protection, exposing this largely unknown ecosystem to unsustainable human activities. To address this emergent problem, the United Nations General Assembly agreed on the legally binding nature of a future agreement on the conservation and sustainable use of BBNJ under the UN Convention on the Law of the Sea (UNCLOS). However, consider a business-as-usual scenario, in which individuals and decision-makers respond to problems rather than working to prevent them, this paper applies the responsive governance lenses to evaluate ten years of Ad Hoc Open-ended Informal Working Group meetings aiming to prove that governance is a problem-driven and it may be tightly connected to the on human perceptions of specific signals and the actors’ relative positions of power. Thus, the chances of having a flexible agreement that will only comply with a partial response to the environmental problem are significant and this will only reduce or mitigate part of the problem but not all. In cases like that, the governance will remain ineffective in some ways.
A regulação do acesso aos Recursos Genéticos Marinhos e a Repartição de Benefícios: O Modelo Brasileiro como inspiração para o Tratado BBNJ
Authors: Novion Henry , Barros-Platiau Ana Flávia
Published: May 2023

A agenda diplomática de regulação do acesso aos recursos genéticos marinhos e a repartição de benefícios deles advindos perpassa grandes arenas multilaterais desde 1992, entre elas a CDB, a BBNJ e a Antártica. Logo, constitui uma oportunidade ímpar para que o Brasil promova seu modelo e mobilize uma coalizão voltada a efetivar a partilha dos benefícios monetários, incluindo aqueles resultantes do uso de informações de sequências genéticas digitalizadas.
O Sistema do Tratado da Antártica e a Organização Marítima Internacional: interações institucionais
Authors: Korber Gonçalves Veronica , Figueiredo dos Santos Leo Evandro
Published: May 2023

O trabalho analisa o processo de interação institucional entre a STA e a Organização Marítima Internacional (OMI), relativa ao transporte marítimo e à prevenção da poluição proveniente de embarcações nas áreas sob responsabilidade do STA, a partir de seis elementos: o reconhecimento da competência; proficiência e dimensão do risco, a influência dos Estados Partes; a agenda ambiental, a convergência legislativa e a supressão de temas sensíveis.
BBNJ Agreement: High Seas Biodiversity as a Common Heritage (of Mankind)?
Authors: De Paiva Toledo André
Published: May 2023

The UNCLOS does not expressly address genetic resources. In 2017, the United Nations convened a conference to negotiate an Agreement on conservation and sustainable use of BBNJ. Based on UNCLOS provisions, which prohibit the modification of the principle of freedom on high seas, it is not possible for marine genetic resources on high seas to be ruled as res communis humanitatis, but as res communis.
The challenge of conducting marine scientific research under the COVID-19 pandemic
Authors: Polejack Andrei
Published: May 2023

This opinion paper highlights the unseen impacts that the current COVID-19 outbreak has posted to ocean sciences, particularly in developing countries. Ocean science diplomacy, i.e. the interplay between ocean science and international affairs, present useful tools to leverage from this new normal and address the need to foster balance between regions in terms of scientific capabilities to unveil the ocean as a public good. The UN Decade of Ocean Science offers a timely framework to advance such discussions.
A dynamical approach to relativity: Desynchronization of clocks in rigid acceleration and gravitational redshift
Authors: Şahin İnanç
Published: May 2023

In this paper, inspired by quantum field theory, or more specifically QED, we propose a dynamical model for relativity. By adopting the approach provided by this dynamical model, we provide a dynamical explanation for relativistic phenomena such as length contraction, time dilation and clock desynchronization. The result of the dynamical approach for clock desynchronization is especially interesting. Our dynamical approach exhausts the freedom for different clock synchronizations on frames accelerated from an initial reference frame, which is allowed by Einstein’s principle approach. Furthermore, our dynamical approach arrives at the interesting conclusion that Einstein’s equivalence principle and gravitational redshift are necessary to explain special relativistic clock desynchronization. This result shows that special relativity by itself is an incomplete theory. If our dynamical model assumptions are assumed to be valid at a fundamental level, it implies some modifications to quantum field theory and general relativity via the equivalence principle. These modifications have been discussed.
Harnessing the Metaverse for Livestock Welfare: Unleashing Sensor Data and Navigating Ethical Frontiers
Authors: Neethirajan Suresh
Published: May 2023

The metaverse, a virtual world comprising a collective virtual shared space where users interact with one another through avatars and computer-generated objects, aims to closely mimic our real world by integrating elements of Artificial Intelligence (AI), immersive reality, advanced connectivity, and Web3. As metaverse technologies gain momentum across multiple sectors, including animal farming, their potential for addressing complex challenges such as climate change and sustainability in precision food production systems becomes increasingly apparent. However, it is crucial to consider the ethical implications and the role of sensor data and livestock behavior analysis in developing metaverse technologies for modern animal farming, given the sensitive and controversial nature of animal welfare. Failure to address these ethical considerations and harness the power of sensor data and behavior analysis could lead to a lack of credibility and insensitivity towards adopting metaverse technologies in the animal farming sector. It is essential to ensure that the development of metaverse technologies does not prioritize technology over animal welfare, ethics, socio-economic implications, and the potential for data-driven insights. Addressing diversity and equity in the context of animal farming and the metaverse is crucial to avoid perpetuating existing inequalities during the implementation of metaverse technologies. This groundbreaking paper ventures into unexplored territory, shedding light on the untapped potential of the metaverse for modern animal farming. While research on this topic is still in its infancy, we embark on a journey of visionary speculation, presenting a compelling technology forecast that envisions the extraordinary possibilities awaiting us in the future. By delving into the metaverse's transformative capabilities, we provide a glimpse into a world where animal farming transcends its traditional limitations and embraces a new era of efficiency, sustainability, and ethical practices.
The Spectrum of the Orthogonal Matrix with its Cube being Symmetric
Authors: Chen Meixiang , Yang Zhongpeng , Lin Zhixing
Published: May 2023

The orthogonal matrix with cube be symmetric is a common class of matrices with important properties. We pay attention to this kind of matrices. By using the close relationship between the eigenvalues of a matrix and the trace of its power, we obtain the algorithm for its all possible different eigenvalues and multiplicities. The calculation formula is expressed only by the trace of a matrix and its power, avoiding solving the characteristic polynomial. The method is simple and practical. Furthermore, a new essential characterization for the sum of orthogonal matrix pairs being orthogonal is given as well.
Wave Climate Variability along the Coastlines of Senegal over the Last 4 Decades
Authors: SAMOU Marcellin SEUJIP , BERTIN Xavier , SAKHO Issa , LAZAR Alban , SADIO Mamadou , DIOUF Mouhamadou BACHIR
Published: May 2023

Knowledge of wave climate is essential for efficient management of the world's coastal areas. Senegal is a relevant case given its high coastal vulnerability to energetic wave conditions. This study investigates wave climates along the coastal zone of Senegal based on a new high-resolution hindcast covering the period 1980-2021. This study evaluates the average, seasonal and extreme values for the wave significant heights (Hs), periods (Tm02/Tp) and mean directions (DIR). In boreal Winter, the wave climate is dominated by swells coming from the North-Atlantic lows, while in boreal Summer, the Southern Coast (from Dakar to Casamance) is exposed to swells generated in the South-Atlantic Ocean. Throughout their refraction around Dakar Peninsula, NW swells rotate by ~100° from NW to SW, while their Hs is roughly halved when reaching the Southern Coast of Senegal. Over the studied period, trends in Hs are weak (~0.6 cm.decade-1) on the Northern Coast, double on the Southern coast (~1.2 cm.decade-1), mostly due to an increase during boreal Summer (2 cm.decade-1). The wave periods show weak trends (~0.05 s.decade-1) and DIRs show weak counterclockwise rotation (-1°.decade-1). These trends are explained by the main climate modes of the Atlantic Ocean (NAO/EA during Winter, SAM during Summer) and are important for future research and long-term monitoring of the Senegalese Coast.
Use of a Visual Scoring System to Assess External Udder Conformation and Its Relationship to Colostrum Quality and Lamb Growth Rates
Authors: Richardson Haley , Ahmadzadeh Amin , Konetchy Denise
Published: May 2023

In sheep raised for meat production, the relationship between external udder conformation, colostrum quality, and lamb growth rates has not received much attention. We hypothesize that ewes with a more desirable udder conformation at lambing have greater colostrum quality and increased growth rates in lambs. Fifty Suffolk ewes were used in this study. Within 6-8 hours of parturition, colostrum samples from both halves of the udder were collected and a visual scoring of the udder was conducted. Colostrum quality was measured for total protein using both optical and Brix refractometers. On day 2, day 45, and day 60 after parturition, lamb weights were recorded, and udder conformation measurements were repeated. A visual scoring system evaluating udder floor (scale 1-4), udder depth (scale 1-9), teat placement (scale 1-9), teat lesions (present or absent), and the presence of wool (present or absent) was used to assess external udder conformation. Normal udder parameters include udder depth scores of 5 or 6, udder floor score of 1 or 2, teat placement scores 4, 5, and 6, and the absence of teat lesions and wool. All ewes not meeting normal parameters were considered to have an abnormal udder. The data was analyzed using the GLM procedure. Mean total colostrum total protein was greater (p = 0.03) in ewes displaying ‘normal’ udder conformation compared with those with ‘abnormal’ (14.82±0.5 and 13.31±0.3mg/dl). Mean Brix values were also greater (p = 0.03) for ewes with a ‘normal’ udder compared to an abnormal udder confirmation, respectively (21.70±0.8 and 19.54±0.5). On day 2 after parturition, mean lamb body weight was not different between ewes with ‘normal’ and abnormal udder (5.38±0.26 vs 5.46±0.15). No difference (p > 0.05) in lamb weights were detected between ewes with normal and abnormal udder conformations on day 45 and 60 after parturition. This data provides evidence of increased colostrum total protein values and increased Brix values present in ewes with ‘normal’ udder conformation and no difference in lamb weights between udder conformations.
Role of Selected Circulating Tumor Biomarkers in Patients with Skeletal Metastatic Pancreatic Neuroendocrine Neoplasms
Authors: Rosiek Violetta , Janas Ksenia , Witkowska Magdalena , Kos-Kudła Beata
Published: May 2023

We investigated the diagnostic capacity of selected circulating biomarkers (CBMs) for the early detection of bone metastasis (BMets) in patients with pancreatic neuroendocrine neoplasms (PanNENs). 115 patients with PanNENs and 40 controls were enrolled. We measured the serum levels of ferritin, cytokeratin 18 (CY18), CA19-9, CA125, AFP, CEA, and beta-2 microglobulin (B2M). 8 PanNENs patients developed BMets, and 107 remained BMets-free. We observed a significantly higher level of CA125 and CY18 in BM-PanNENs patients vs. non-BM-PanNENs patients (p = 0.01 and p = 0.04, respectively). CA125, CY18, and B2M area under receiver operator characteristic (AUROC) analyses differentiated BM-PanNENs from non-BM-PanNENs patients; CA125 area under the curve (AUC) 0.77, p < 0.01; CY18 AUC data were 0.72, p = 0.03, and B2M AUC 0.67, p = 0.02. Based on CBMs metrics in both subgroups, we reached a sensitivity/specificity for CA125 of 75/76%; for CY18 of 75/69%, for B2M of 100/50%, for CA125 and CY18 combination 93/90%, respectively. The useful CBMs for BM-PanNENs patients detection were CA125, CY18, and B2M. They seem to have the diagnostic capacity as a fair single biomarker and CA125&CY18 combination panel for the detection of BMets.
Beyond Bullying, Aggression, Discrimination, Social Safety: Development of an Integrated Negative Work Behavior Questionnaire (INWBQ)
Authors: Verschuren Cokkie , Tims Maria , De Lange Annet H.
Published: May 2023

Negative work behavior (NWB) threatens employee well-being. There are numerous constructs that reflect NWBs, such as bullying, aggression, and discrimination and they are often examined in isolation of each other, limiting scientific integration of these studies. We aim to contribute to this research field by developing a diagnostic tool with content validity on the full spectrum of NWBs. First, we provide a full description of how we tapped and organized content from 44 existing NWB measurement instruments and 48 studies. Second, we discussed our results with experts (N = 3) in this research field to check for missing studies and to discuss our integration results. This two-stage process yielded a questionnaire measuring physical, material, psychological, sociocultural, and digital NWB. Furthermore, the questions include a range of potential actors of NWB, namely internal (employees, managers) and external actors (clients, customers, public, family members) at work and their roles (i.e., target, perpetrator, perpetrator's assistant, target's defender, outsider, and witness of NWBs). Finally, the questionnaire measures what type of harm is experienced (i.e., bodily, material, mental, and social harm).
Molecular Mechanism in the Development of Pulmonary Fibrosis in Sarcoid Patient
Authors: Cocconcelli Elisabetta , Bernardinello Nicol , Castelli Gioele , Petrarulo Simone , Bellani Serena , Saetta Marina , Spagnolo Paolo , Balestro Elisabetta
Published: May 2023

Sarcoidosis is a multisystemic disease of unknown etiology characterized by the formation of granulomas in various organs, especially lung and mediastinal hilar lymph nodes. The clinical course and manifestations are unpredictable: spontaneous remission can occur in approximately two thirds of patients; up to 20% of patients have chronic course of the lung disease (called Ad-vanced Pulmonary Sarcoidosis) resulting in progressive loss of lung function, sometimes life-threatening that can lead to respiratory failure and death. The immunopathology mechanism leading from granuloma formation to the fibrosis in APS still remains elusive. Recent studies have provided new insights into the genetics factors and immune components involved in the clinical manifestation of the disease. In this review we aim to summarize the clinical-prognostic charac-teristics and molecular pathways which are believed to be associated with the development of APS
DGKζ Depletion Attenuates BRCA1-Mediated DNA Repair Mechanism
Authors: Tanaka Toshiaki , Iino Mitsuyoshi , Goto Kaoru
Published: May 2023

DNA double-strand breakage is the most lethal damage to chromosomal DNA. It activates a series of cellular DNA damage response pathways, including DNA damage sensing, control of cell cycle arrest and apoptosis, and DNA repair. DNA damage response pathways are regulated by complex signaling machineries. Of the intracellular signaling cascades, diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to generate phosphatidic acid (PA). Because both DG and PA serve as second messengers, DGK activity induces a shift of signaling pathways from DG-mediated to PA-mediated cascades, thereby implicating DGK in the regulation of widely various functions. Reportedly, one member of the DGK family, DGKζ, is intimately involved in the regulation of stress responses through p53 and NF-κB. Stresses such as ischemia and infarction cause DGKζ downregulation. Experimental DGKζ depletion renders cells and mice vulnerable to various stressors such as chemotherapeutic agents and ionizing irradiation. Nevertheless, how DGKζ is involved in DNA repair, a critical event of DNA damage response for survival remains unknown. For this study, we examined how DGKζ depletion affects DNA repair mechanisms. We demonstrated that DGKζ depletion causes attenuation of Akt activation and DNA-PK protein expression upon DNA damage, which might engender downregulated BRCA1 protein synthesis and stability. Results suggest that DGKζ depletion attenuates BRCA1-mediated DNA repair machinery, thereby conferring vulnerability to DNA damage.
Assessing the Development and Intensity of the Urban Heat Island through Weather Types in the Attica Region, Greece
Authors: Petrou Ilias , Kyriazis Nikolaos , Kassomenos Pavlos
Published: May 2023

In this study we investigated the association between weather types (WTs) and the Urban Heat Island Intensity (UHII) in the region of Attica (Greece). The application of the methodology results in ten WTs over Attica region. The UHII was calculated for every hour of the day from 2008 to 2017, using a new air temperature dataset produced by Copernicus Climate Change Service. To have more clear results concerning the association between WTs and UHII, we have used also the upper 5% of UHII (Urban Overheating-UO). The UO have been estimated for two-time intervals (daytime and nighttime) and for the warm period (June-September). The UHII frequency distribution as well as the spatial characteristics of the UO were also investigated. It was found that UO was amplified under WT2 during the night while, WT10 was mainly responsible for exacerbated UO magnitude at daytime, in all months. Furthermore, analysis results revealed that the UO effect is more pronounced in Athens during the night, especially at Athens center. The daytime hot-spots identified mainly in sub-urban and rural areas. Therefore, this methodology may help for heat mitigation strategies and climate adaptation measures, in urban environments.
Superior High Transistor’s Effective Mobility of 325 cm2/V-s by 5-nm Quasi-Two-Dimensional SnON nFET
Authors: Pooja Pheiroijam , Chien Chun Che , Chin Albert
Published: May 2023

This work reports the first nanocrystalline SnON (7.6 % Nitrogen content) n-type nanosheet Field-Effect Transistor (nFET) with transistor’s effective mobility (µeff) as high as 357 and 325 cm2/V-s at electron density (Qe) of 5×1012 cm-2 and ultra-thin body thickness (Tbody) of 7 and 5 nm, respectively. At the same Tbody and Qe, these µeff values are significantly higher than single crystalline Si, InGaAs, thin-body Si-on-Insulator (SOI), two-dimensional (2D) MoS2 and WS2. New discovery of slower µeff decay rate at high Qe than SiO2/bulk-Si universal curve was found, owing to one order of magnitude lower effective field (Eeff) by more than 10 times higher dielectric constant () in channel material, which keeps the electron wave-function away from the gate-oxide/semiconductor interface and lowers the gate-oxide surface scattering. In addition, the high µeff is also due to the overlapped large radius s-orbitals, low 0.29 mo effective mass (me*) and low polar optical phonon scattering. SnON nFETs with record-breaking µeff and quasi-2D thickness enable potential monolithic three-dimensional (3D) integrated circuit (IC) and embedded memory for 3D biological brain-mimicking structures.
Performing Advanced Trauma Life Support (ATLS) across Borders -Mid-Term Follow Up of the Aeromedical Evacuation after Civilian Bus Accident at Madeira
Authors: Imach Sebastian , Deschler Andreas , Sammito Stefan , Reis Miguel , Michaelis Sylta , Marche Ben , Paffrath Thomas , Bouillon Bertil , Tjardes Thorsten
Published: May 2023

On April 17, 2019, a coach with tourists from Germany crashed in Madeira requiring repatriation by the German Air Force. The Advance Trauma Life Support (ATLS) concept was the central component of patient care. Data in Madeira were collected through a structured interview. The analysis of the Aeromedical Evacuation was based on intensive care transport records. In Germany all available were reviewed for data collection. Quality of life (HRQoL) was evaluated by the 12-item Short-Form Health Survey (SF-12). Twenty-eight prehospital patients were transported to the Level III Trauma Center in Funchal (Madeira). Five operative procedures were performed. Fifteen patients were eligible for Aeromedical Evacuation (AE). In the second hospital phase in Germany in total 82 radiological images and nine operations were performed. Hospital stay lasted 11 days (median, IQR 10–18). Median Follow-up (14 of 15 patients) was 16 months (IQR 16–21). 80% (8 out of 10) showed an increased risk for post-traumatic stress disorder (PTSD). Six key findings were identified in this study: divergent injury classification, impact of AE mission on health status, lack of communication, need of PTSD prophylaxis, patient identification, media coverage. Those findings may improve AE missions in the future e.g. required after armed conflicts.
A Novel Anti-CD44 Variant 10 Monoclonal Antibody is Useful for Immunohistochemical Analysis against Oral Squamous cell carcinomas
Authors: Ishikawa Kenichiro , Suzuki Hiroyuki , Kaneko Mika K , Kato Yukinari
Published: May 2023

CD44 is known as a cancer stem cell marker of head and neck squamous cell carcinoma (HNSCC) and plays a critical role in cancer malignant progression. Splicing variant isoforms of CD44 (CD44v) are overexpressed in cancers and considered a promising target for cancer therapy. Several monoclonal antibodies (mAbs) against CD44 have been developed by immunizing mice with CD44v3–10-overexpressed cancer cells. In this study, we characterized a novel clone, C44Mab-18 (IgM, kappa). C44Mab-18 reacted with CHO/CD44v3–10, but not with CHO/CD44s by flow cytometry. Enzyme-linked immunosorbent assay revealed that the epitope of C44Mab-18 is determined to be the border sequence between variant 10 and the constant exon 16-encoded sequence. Flow cytometry showed that C44Mab-18 recognizes HSC-3, an oral squamous cell carcinoma(OSCC) cell line. The apparent dissociation constant (KD) of C44Mab-18 for CHO/CD44v3–10 and HSC-3 was determined to be 1.6 × 10−7 M and 1.7 × 10−7 M, respectively. C44Mab-18 detected CD44v3–10, but not CHO/CD44s in western blotting. Furthermore, C44Mab-18 detected endogenous CD44v10 in immunohistochemistry using OSCC tissues. Taken together, C44Mab-18 is useful for detecting CD44v10 in flow cytometry and immunohistochemistry.
Clinical and Epidemiological Features, Mechanism of Action, and Diagnosis of Global Pandemic Infectious Disease, COVID-19, and its Comparison with SARS, MERS, and H1N1: A Brief Overview
Authors: Hormozi Jangi Saeed Reza
Published: May 2023

The coronavirus disease 2019 (COVID-19) is a novel global pandemic infectious disease with higher potential for outbreaks than the other epidemic disease such as severe acute respiratory syndrome (SARS), influenza A (H1N1), and the Middle East respiratory syndrome (MERS), which identified in China on December 31, 2019. This disease is caused by a new generation of betacoronavirus termed as the 2019 novel coronavirus (2019-nCoV) or SARS-CoV-2. Although, the first report of this disease was in recent months, now, the COVID-19 is known as a global pandemics. Hence, the aim of this article is the quick review of the recent studies on the novel coronavirus disease 2019 including researches on the epidemiological parameters, mechanism of action, diagnosis, and treatment of the novel coronavirus disease, as well as clinical features of patients infected with COVID-19. Moreover, the novel COVID-19 has comprised of SARS, H1N1, and MERS.
Serum Biomarker Concentrations on Admission in Acute Traumatic Brain Injury: Associations with, TBI Severity, Toxoplasma gondii Infection and Outcome in a Referral Hospital Setting, Cameroon
Authors: Buh Franklin Chu , Taiwe Germaine Sotoing , Kobeissy Firas H. , Wang Kevin W. , Maas Andrew I.R. , Meh Basil Kum , Mathieu Motah , Youm Eric , Hutchinson Peter J.A. , Sumbele Irene Ule Ngole
Published: May 2023

Despite the available literature on traumatic brain injury (TBI) biomarkers elsewhere, data are limited or non-existent in sub-Saharan Africa (SSA). The aim of the study was to analyse associations in acute TBI between admission serum biomarker concentrations and TBI severity, CT-scan findings and outcome as well as explore the influence of concurrent Toxoplasma gondii infection. Concentrations of serum biomarkers (GFAP, NFL Tau, UCH-L1, and S100B) were measured and Toxoplasma gondii detected in samples obtained <24 hours post-injury. The GOSE was used to evaluate 6 months outcome. All biomarkers levels increased with severity of TBI, but this increase was significant only for NFL (P=0.01). GFAP values significantly increased (P=0.026) in those with unfavorable outcome. Tau levels were higher in those who died (P=0.017). GFAP and NFL were sensitive to CT-scan pathology (p values respectively 0.004 and 0.002). S100B levels were higher (P<0.001) in TBI patients seropositive to Toxoplasma gondii. NFL was found to be sensitive to TBI severity while NFL and GFAP were predictive of CT intracranial abnormalities. Increased levels of GFAP and Tau were associated with poorer outcomes 6 months after TBI. S100B levels were significantly higher in T. gondii seropositive TBI patients.
Research Progress of Orchid-Fungal-Bacterial Interaction: Theory, Opportunities, and Challenges
Authors: He Xin , Chen Deqiang , Zhang Meng-Meng , Huang Ye , Zheng Qingyao , Ahmad Sagheer , Liu Zhong-Jian , Lan Siren
Published: May 2023

Orchids are often a mystery because of their close and complex relationships with various microorganisms in the natural environment. Orchids rely on microorganisms to obtain nutrients, affecting their seed germination, protocorm, and adult plant growth. Currently, the majority of relevant research is concentrated on isolating and identifying environmental microorganisms that support orchid development and growth. With the development of metagenomic technology, our understanding of orchid mycorrhizal fungi (OMF) and root-associated bacteria (RAB) has been expanded. New research results and discoveries have emerged, which require a comprehensive assessment to provide a reference for studying microorganisms related to orchids. Therefore, we present a comprehensive summary, identifying significant inadequacies of present methodologies while providing ideas for further research.
Pre-season ACL Risk Classification of Professional and Semi-professional Football Players, via a Holistic Test-battery
Authors: Tsarbou Charis , Liveris Nikolaos , Xergia Sofia , Tsekoura Maria , Fousekis Konstantinos , Tsepis Elias
Published: May 2023

The study aimed to identify football players at high risk (HR) for anterior cruciate ligament (ACL) injury via a four-test battery and assess possible factors affecting classification. Ninety-one professional and semi-professional athletes participated in a field-based preseason screening. Aknowledged inter-limb asymmetry limits for quadriceps and hamstrings isometric strength, and Single Leg Triple Hop for distance, in addition to the Landing Error Scoring System (LESS) comprised the test-battery. Additional assessment of hip adductors and core stability completed the global functional profile of the players. Sixty-one players were identified as HR and 30 as low-risk (LR) for ACL injury. Test-battery classified adequately 78,0% of them (Chi-square= 27,485 p=,000), identifying only 4 misclassified cases in the LR group, this low number being important for avoiding improper treatment of injury-prone athletes. All partcipants were considered healthy, and history of a previously rehabilitated injury did not interfere with the results. LESS seems to be the optimal criterion for classification and also the best predictor of both the initial grouping and the secondary one with the wrong vs correct classification cases. The proposed test-battery provides a promising option for field-based preseason ACL-risk assessment of football players and needs to be studied prospectively.
Dendritic Mesoporous Organosilica Nanoparticles with Photosensitizers for Cell Imaging, siRNA Delivery and Protein Loading
Authors: Omar Haneen , Jakimoska Sara , Guillot Julia , Alsharaeh Edreese , Charnay Clarence , Cunin Frédérique , Bessière Aurélie , Durand Jean-Olivier , Raehm Laurence , Lichon Laure , Onofre Mélanie , Gary-Bobo Magali
Published: May 2023

Dendritic Mesoporous Organosilica Nanoparticles (DMON) are a new class of biodegradable nanoparticles suitable for biomolecules delivery. In order to escape from the endosomes-lysosomes and to deliver biomolecules in the cytoplasm of cells, we studied photochemical internalization (PCI) and photodynamic therapy (PDT) of DMON. We added photosensitizers in the framework of DMON. DMON were also loaded with siRNA or FVIII factor protein. We made four formulations with four different photosensitizers, The photosensitizers allowed to perform imaging of DMON in cancer cells, but the presence of the tetrasulfide bond in the framework of DMON quenched the formation of singlet oxygen. Fortunately one formulation allowed to efficiently deliver proapoptotic siRNA in MCF-7 cancer cells leading to 31% of cancer cell death, without irradiation. For FVIII protein, it was loaded in two formulations with drug loading capacities (DLC) up to 25%. In conclusion DMON are versatile nanoparticles which allowed to load siRNA and to deliver it in cancer cells, and to load FVIII protein with good DLC. Due to the presence of tetrasulfide, it was not possible to perform PDT and PCI.
Molecular Biological Effects of Weak Low-frequency Magnetic Fields: Current State and Future Prospects
Authors: Krylov Viacheslav V.
Published: May 2023

The review presents the most developed by date hypotheses on the mechanisms of the influence of low-frequency magnetic fields (LFMF) on organisms. Biophysical models that explain the resonance-like responses of biological systems to LFMF with a specific frequency and amplitude are described. Two groups can be distinguished among these models: one considers ions-cofactors of proteins as the primary targets for the LFMF influence, and the other regards the magnetic moments of particles in biomolecules. Attention is paid to the dependence of resonance-like LFMF effects on the cell type. A radical-pair mechanism of the magnetic field's influence on biochemical processes is described with the example of cryptochrome. Conditions for this mechanism's applicability to explain the biological effects of LFMF are given. A model of the influence of LFMF on radical pairs in biochemical oscillators, which can explain the frequency-amplitude efficiency windows of LFMF, is proposed.
Coping as a Mediator between Attachment and Depression either in Pregnancy or in the Early Postpartum Period: A Structural Equation Modelling Approach
Authors: Altamura Mario , Leccisotti Ivana , De Masi Laura , Gallone Fiammetta , Ficarella Livia , Severo Melania , Biancofiore Simona , Ventriglio Antonio , Petito Annamaria , Maruotti Giuseppe , Nappi Luigi , Bellomo Antonello
Published: May 2023

Abstract
Peripartum depression (PPD) is a major complication of pregnancy and many risk factors have been
associated with its development, including dysfunctional coping strategies and insecure attachment styles, both during pregnancy and postpartum. The aim of our study was to investigate the role of coping strategies in mediating the relationship between women’s attachment style and PPD in pregnancy, and one week after childbirth, in a large cohort of women. We hypothesized that the relationship between anxious and avoidant attachment and PPD would be mediated by use of maladaptive coping strategies. The assessment instruments were Edinburgh Postnatal Depression Scale (EPDS), Brief Coping Orientation for Problem Experiences (COPE), Experiences in Close Relationship Scale (ECR). The results indicated that the effect of insecure attachment styles (anxious and avoidant attachment) on antepartum depressive symptomatology was partially mediated by dysfunctional coping styles. Anxious attachment has also an indirect significant effect on postpartum depression through emotional coping; however, avoidant attachment does not seem to be significantly related to postpartum depression. Our findings revealed that not only it is important to consider attachment in understanding PPD but also that coping plays an important role in these relationships. These findings would help a preventive coping-based intervention strategy to enhance the capacity of women with insecure attachment styles to use more adaptive coping during and after pregnancy.
Small Ruminant Lentivirus Infection in Sheep and Goat in North Portugal: Seroprevalence and Risk Factors
Authors: Jacob-Ferreira João , Coelho Ana Cláudia , Grau Vila Ana , Lacasta Delia , Quintas Hélder
Published: May 2023

Small ruminant lentivirus (SRLV) are infected and transmitted among ovine and caprine species. This disease is a severe problem for small ruminant production, not only for animals’ wellbeing but also for the herd’s efficiency. The main aim of this research was to quantify the seroprevalence and associated risk factors for SRLV infection in the north region of Portugal. Collected samples from a total of 150 herds, of which 129 (86.0%; 95% CI: 80.67% - 91.33%) had at least one seropositive animal. Out of 2607 individual blood samples, 1074 (41.2%) were positive for SRLV. The risk factors associated with SRLV infection were: specie (caprine), age (> 2 years old), herd size (> 100 animals), production system (intensive), production aptitude (milk), type of activity (professional), participation in livestock competitions (yes), buy replacement young ewe (yes) and rearing (natural). This knowledge empowers the implementation of effective preventive measures. Overall, biosecurity measures should be promoted and implemented to aim reducing viral transmission, with the main goal of reducing the prevalence of this disease. Completely, we understand that government authorities should promote and audit voluntary control and eradication programs in small ruminant herds in the region studied.
Inclusive Leadership and Psychological Contract Fulfilment a Source of Proactivity and Well-Being of Knowledge Workers
Authors: Rogozińska-Pawełczyk Anna
Published: May 2023

Proactivity is a particularly important attribute of knowledge-intensive organizations, where the work required to increase the potential of knowledge-intensive employees is crucial. A priority challenge for these firms is also to understand the increasing importance of the functioning of cognitive mechanisms leading to increased knowledge workers' well-being following the implementation of the psychological contract. The aim of this article is to identify the relationship between inclusive leadership, the fulfillment of the psychological contract, two dimensions of well-being: workplace and life well-being and knowledge workers' proactivity. Based on survey data collected through the CAWI method from 1.000 knowledge workers employed in Polish companies in the business services sector, the research hypotheses were tested using a stepwise equation modelling (SEM) technique, leading to a model containing all the main constructs. The results obtained indicate that inclusive leadership positively impacts the fulfillment of the psychological contract. Furthermore, the fulfillment of the psychological contract positively affects proactive working behavior with and the wellbeing of knowledge workers. Along with proactive work behavior, two dimensions of well-being, were examined as outcome variables. The analysis also shows that knowledge-intensive organizations, intending to build the proactivity of their employees and nurture a high level of well-being in their lives and in the workplace, should take care to fulfil the expectations and obligations of the psychological contract. However, one way to achieve this is for managers to use an inclusive management style, which supports an atmosphere of a safe working environment in a diverse setting and leads to employees feeling comfortable sharing their opinions and ideas. The study of inclusive leadership in the context of knowledge-intensive organizations provides human resource professionals and employee man-agers with important insights into how inclusive leadership can effectively contribute to the psychological contract, which will consequently lead to proactive work behavior and also improve employees' workplace and life well-being.
Receptor for Activated C Kinase1B (RACK1B) Delays Salinity-induced Senescence of Rice Leaves through Negative Regulation of Chlorophyll Degradation
Authors: Rahman Md Ahasanur , Ullah Hemayet
Published: May 2023

Abstract: The widely conserved RACK1 protein is a WD-40 type scaffold protein that regulates diverse environmental stress signal transduction pathways. Arabidopsis RACK1A has been reported to interact with various proteins in salt stress and Light-Harvesting Complex (LHC) pathways. However, the mechanism of how RACK1 contributes to the photosystem and chlorophyll metabolism in stress conditions remains elusive. Using T-DNA-mediated activation tagging transgenic rice (Oryza sativa L.) lines, we show that leaves from rice RACK1B gene (OsRACK1B) gain-of-function (RACK1B-OX) plants exhibit the stay-green phenotype under salinity stress. In contrast, leaves from down-regulated OsRACK1B (RACK1B-UX) plants display an accelerated yellowing. qRT-PCR analysis revealed that several genes encoding chlorophyll catabolic enzymes (CCEs) are differentially expressed in both RACK1B-OX and RACK1B-UX rice plants. In addition to CCEs, STAY-GREEN (SGR) is a key component that forms the SGR-CCE complex in senescing chloroplasts, which causes LHCII complex instability. Transcript and protein profiling revealed a significant upregulation of OsSGR in RACK1B-UX plants than that in RACK1B-OX rice plants during salt treatment. The results imply that senescence-associated transcription factors (TFs) are altered in accordance with altered OsRACK1B expression, indicating a transcriptional reprogramming by OsRACK1B and a novel regulatory mechanism involving the OsRACK1B-OsSGR-TFs complex. Our findings suggest that ectopic expression of OsRACK1B negatively regulates chlorophyll degradation, leads to the steady level of LHC-II isoform Lhcb1, an essential prerequisite for the state transition of photosynthesis for adaptation, and delays salinity-induced senescence. Taken together, these results provide important insights into the molecular mechanisms of salinity-induced senescence, which can be useful in circumventing the effect of salt on photosynthesis and in reducing the yield penalty of important cereal crops, like rice, in global climate change conditions.