bluuebunny/crossref_metadata_2025 huggingface dataset:
Eligibility of real-world patients with metastatic lung cancer for clinical trial participation: A population-based analysis.
Authors: Batra Atul , Kong Shiying , Rigo Rodrigo , Cheung Winson Y.
Published: October 2020

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Background: Due to highly selective enrollment in clinical trials, the generalizability of results may be limited. This study aimed to identify the proportion of real-world patients with metastatic lung cancer (MLC) eligible to participate in a clinical trial. Methods: We identified patients diagnosed with MLC in a large Canadian province from 2004 to 2017. Ineligibility to participate in a clinical trial was defined by common exclusion criteria: age > 75 years, anemia, comorbid conditions (heart disease, uncontrolled diabetes, kidney disease, or liver disease) and history of a prior malignancy or immunosuppression. Logistic regression models were used to describe the likelihood of receiving systemic therapy and Cox regression models were constructed to determine the association of trial ineligibility with overall survival (OS). Results: A total of 13,996 patients were included; the median age was 70 years and 46.9% were women. Of these, 8,615 (61.6%) were trial-ineligible. The common reasons for ineligibility were age > 75 years (11.5%), abnormal renal function (8.3%) and prior immunosuppression (3.2%). Further, 32.3% of patients were ineligible by multiple exclusion criteria. In the real-world, 40.6% and 21.8% of trial-eligible and ineligible patients received systemic therapy (P < .001), respectively. After adjusting for age and sex, trial-ineligible patients had lower odds of receiving systemic therapy (odds ratio, .84; 95% confidence interval [CI], .76-.92; P < .001). At a median follow-up of 66.2 months, the median OS of trial-eligible patients was 5.1 months as compared to 2.9 months in those deemed ineligible (P < .001). Receipt of systemic therapy was associated with longer OS in both trial-eligible (10.5 vs 2.7 months, P < .001) and ineligible (9.3 vs 2.1 months, P < .001) patients. In a Cox regression model that adjusted for age, sex and systemic therapy, ineligibility was predictive of worse OS. Conclusions: More than half of patients with MLC are ineligible to participate in clinical trials. Real-world use of systemic therapy was generally low, but its use was associated with improvement in OS even among individuals considered trial-ineligible. Clinical trials should broaden their eligibility criteria to better represent the phenotype of real-world patients so that findings are more generalizable. [Table: see text]
Adrenal Venous Sampling–Guided Adrenalectomy Rates in Primary Aldosteronism: Results of an International Cohort (AVSTAT)
Authors: Ohno Youichi , Naruse Mitsuhide , Beuschlein Felix , Schreiner Florentine , Parasiliti-Caprino Mirko , Deinum Jaap , Drake William M , Fallo Francesco , Fuss Carmina T , Grytaas Marianne A , Ichijo Takamasa , Inagaki Nobuya , Kakutani Miki , Kastelan Darko , Kraljevic Ivana , Katabami Takuyuki , Kocjan Tomaz , Monticone Silvia , Mulatero Paolo , O’Toole Sam , Kobayashi Hiroki , Sone Masakatsu , Tsuiki Mika , Wada Norio , Williams Tracy Ann , Reincke Martin , Tanabe Akiyo
Published: October 2020

Context

Adrenal venous sampling (AVS) is the current criterion standard lateralization technique in primary aldosteronism (PA). Japanese registry data found that 30% of patients with unilateral PA did not undergo adrenalectomy, but the reasons for this and whether the same pattern is seen internationally are unknown.

Objective

To assess the rate of AVS-guided adrenalectomy across an international cohort and identify factors that resulted in adrenalectomy not being performed in otherwise eligible patients.

Design, Setting, and Participants

Retrospective, multinational, multicenter questionnaire-based survey of management of PA patients from 16 centers between 2006 and 2018.

Main Outcome Measures

Rates of AVS implementation, AVS success rate, diagnosis of unilateral PA, adrenalectomy rate, and reasons why adrenalectomy was not undertaken in patients with unilateral PA.

Results

Rates of AVS implementation, successful AVS, and unilateral disease were 66.3%, 89.3% and 36.9% respectively in 4818 patients with PA. Unilateral PA and adrenalectomy rate in unilateral PA were lower in Japanese than in European centers (24.0% vs 47.6% and 78.2% vs 91.4% respectively). The clinical reasoning for not performing adrenalectomy in unilateral PA were more likely to be physician-derived in Japan and patient-derived in Europe. Physician-derived factors included non-AVS factors, such as good blood pressure control, normokalemia, and the absence of adrenal lesions on imaging, which were present before AVS.

Conclusion

Considering the various unfavorable aspects of AVS, stricter implementation and consideration of surgical candidacy prior to AVS will increase its diagnostic efficiency and utility.
Phenotypic Variability of Patients With PAX8 Variants Presenting With Congenital Hypothyroidism and Eutopic Thyroid
Authors: Camats Núria , Baz-Redón Noelia , Fernández-Cancio Mónica , Clemente María , Campos-Martorell Ariadna , Jaimes Nadya , Antolín María , Garcia-Arumí Elena , Blasco-Pérez Laura , Paramonov Ida , Mogas Eduard , Soler-Colomer Laura , Yeste Diego
Published: October 2020

Purpose

Thyroid dyshormonogenesis is a heterogeneous group of hereditary diseases produced by a total/partial blockage of the biochemical processes of thyroid-hormone synthesis and secretion. Paired box 8 (PAX8) is essential for thyroid morphogenesis and thyroid hormone synthesis. We aimed to identify PAX8 variants in patients with thyroid dyshormonogenesis and to analyze them with in vitro functional studies.

Patients and Methods

Nine pediatric patients with a eutopic thyroid gland were analyzed by the Catalan screening program for congenital hypothyroidism. Scintigraphies showed absent, low, or normal uptake. Only one patient had a hypoplastic gland. On reevaluation, perchlorate discharge test was negative or compatible with partial iodine-organization deficit. After evaluation, 8 patients showed permanent mild or severe hypothyroidism. Massive-sequencing techniques were used to detect variants in congenital hypothyroidism-related genes. In vitro functional studies were based on transactivating activity of mutant PAX8 on a TG-gene promoter and analyzed by a dual-luciferase assays.

Results

We identified 7 heterozygous PAX8 exonic variants and 1 homozygous PAX8 splicing variant in 9 patients with variable phenotypes of thyroid dyshormonogenesis. Five were novel and 5 variants showed a statistically significant impaired transcriptional activity of TG promoter: 51% to 78% vs the wild type.

Conclusions

Nine patients presented with PAX8 candidate variants. All presented with a eutopic thyroid gland and 7 had deleterious variants. The phenotype of affected patients varies considerably, even within the same family; but, all except the homozygous patient presented with a normal eutopic thyroid gland and thyroid dyshormonogenesis. PAX8 functional studies have shown that 6 PAX8 variants are deleterious. Our studies have proven effective in evaluating these variants.
Ideology Critique 2.0
Authors: Irr Caren
Published: October 2020

This essay differentiates the project of ideology critique proper from its less ambitious relative, propaganda labeling. It then proceeds to identify four tasks whose undertaking is necessary in order to update and refresh the project of ideology critique. These four tasks include: 1) distinguishing between ideology and propaganda; 2) understanding ideology in relation to current conditions—especially the abundance and novelty of affect, the shrinkage and acceleration of the ideologeme, and the global circuitry of intellectual exchange; 3) emphasizing the affirmative aspects of critique; and 4) situating ideology in relation to the dynamism of matter—that is to say, capital. Tackling these tasks brings ideology critique into a new phase and confirms its contributions to a collective project of emancipation and survival.
Surface Critique
Authors: Kaufman Eleanor
Published: October 2020

Against the idea that thinkers such as Althusser practice a form of ideology critique that is equivalent to a style of “deep reading,” at issue is a model of critical analysis that attends to what is readily perceptible on the surface but not conceptualized as such. In the mid-1960s, Althusser and Foucault, not unlike Lacan, propose similar models of reading that focus on what is visible yet invisible insofar as not fully recognized. However, Ricardo serves as a nodal point dividing Althusser’s and Foucault’s otherwise strikingly parallel modes of adjacent reading, or surface critique: for Althusser, Ricardo’s difference from Marx represents the break between ideology and science; for Foucault, Ricardo and Marx are entirely of the same moment.
Single? Great? Collective?
Authors: Robbins Bruce
Published: October 2020

Fredric Jameson’s latest book, Allegory and Ideology (2019), returns to the provocative proposition that he floated in The Political Unconscious: Narrative as a Socially Symbolic Act (1981): that humankind’s cultural past is only available to us today if we believe that “the human adventure is one”—a series of efforts to wrest a realm of freedom from the realm of necessity. This essay examines the new book for evidence of possible fluctuations in Jameson’s commitment to a “single great collective story,” underlining in particular the subversiveness of the adjective “great” but also his re-affirmation of a particular Jamesonian version of constructivism, the Marxist spin he puts on loose and generalized notions of “X is a construct” and “everything is narrative.” Jameson’s loyalty to the concept of “ideology” is read here as another moment in his long-lasting dialogue with the late Hayden White. And his loyalty to the concept of “allegory” is read as dialectical in an especially courageous sense: a willingness to concede that the ability to affirm a “single great collective story” depends both on allegory, which works by a respectful but not reverential attention to cultural differences, and on the model of imperial power, which provides Jameson with his 1981 model of four-fold interpretation.
The Dialectic of Space
Authors: Cole Andrew
Published: October 2020

The spatial dialectic is an important familiar phrase in critical writing, but it nonetheless needs continued elaboration and more working out as a concept. This essay proposes some fundamentals for thinking a dialectic that is unrelentingly spatial and unapologetically material. It first seeks to spatialize temporal logics like contradiction through the Hegelian concept of “material contradiction,” which is outside of time, language, and consciousness. It then tries to ponder the built environment as composed of overlapping material contradictions, multiple sites of praxes—past, present, and future—whence a spatial dialectic issues.
Perturbation analysis of a multi-morphogen turing reaction-diffusion stripe patterning system reveals key regulatory interactions
Authors: Economou Andrew D. , Monk Nicholas A. M. , Green Jeremy B. A.
Published: October 2020

Periodic patterning is widespread in development and can be modelled by Reaction-Diffusion (RD) processes. However, minimal two-component RD descriptions are vastly simpler than the multi-molecular events that actually occur and are often hard to relate to real interactions measured experimentally. Addressing these issues, we investigated the periodic striped patterning of the rugae (transverse ridges) in the mammalian oral palate focusing on multiple previously implicated pathways: FGF, Hh, Wnt and BMP. For each, we experimentally identified spatial patterns of activity and distinct responses of the system to inhibition. Through numerical and analytical approaches, we were able to constrain substantially the number of network structures consistent with the data. Determination of the dynamics of pattern appearance further revealed its initiation by epithelium-specific FGF and Wnt "activators" and Hh "inhibitor", while BMP and mesenchyme-specific-FGF signalling were incorporated once stripes were formed. This further limited the number of possible networks. Experimental constraint thus limited the number of possible minimal networks to 154, just 0.004% of the number of possible diffusion-driven instability networks. Together these studies articulate the principles of multi-morphogen RD patterning and demonstrate the utility of perturbation analysis for constraining RD systems.
Genetic developmental timing revealed by inter-species transplantations in fish
Authors: Fuhrmann Jana Franziska , Buono Lorena , Adelmann Leonie , Morales Juan Ramón Martinez , Centanin Lázaro
Published: October 2020

The path from a fertilised egg to an embryo involves the coordinated formation of cell types, tissues and organs. Developmental modules (Raff, 1996) comprise discrete units specified by self-sufficient genetic programs that can interact among each other during embryogenesis. Here we took advantage of the different span of embryonic development between two far related teleosts, zebrafish (Danio rerio) and medaka (Oryzias latipes), of 3 and 9 days respectively, to explore modularity principles. We report that inter-species blastula transplantations result in the ectopic formation of a retina formed by donor cells — a module. We show that the developmental time of the retina follows a genetic program: an ectopic zebrafish retina in medaka develops with zebrafish dynamics. Heterologous transplantation results in a temporal decoupling between the donor retina and host organism, illustrated by two paradigms that require retina-host interactions: lens recruitment and retino-tectal projections. Our results uncover a new experimental system to address temporal decoupling along embryonic development, and highlight the presence of largely autonomous but yet interconnected developmental modules orchestrating organogenesis.
Pickleball: Review and Clinical Recommendations for this Fast-growing Sport
Authors: Vitale Kenneth , Liu Steven
Published: October 2020

Pickleball is a single or doubles volley sport played with paddles and ball on a hardcourt. Growing in popularity in recent years, injuries can occur similar to racquet sports; however, there is a scarcity of references in the literature for sports medicine providers encountering these athletes and injuries. This review provides clinicians treating pickleball athletes with an overview of the sport, a case study demonstrating the significant injuries that can occur in pickleball, and a review of the available literature. We provide a discussion on common pickleball injuries, injury prevention strategies, and event coverage recommendations to better equip sports medicine providers with a base of knowledge and a clinical approach to treat these athletes, or “picklers,” who enjoy this fast-growing sport.
Common Injuries in Whitewater Rafting, Kayaking, Canoeing, and Stand-Up Paddle Boarding
Authors: Spittler Jack , Gillum Ryan , DeSanto Kristen
Published: October 2020

Paddle sports continue to be popular forms of outdoor recreation in the United States and around the world. This includes not only the more traditional sports of rafting, kayaking, and canoeing but also the newer and growing sport of stand-up paddle boarding. Because these sports are based in an aquatic environment, and frequently whitewater, there are unique, significant risks of injury. Overall, injuries in paddling sports are mostly musculoskeletal and are both acute and chronic in nature. Some injuries, such as environmental and head injuries, are especially problematic because they can lead to serious morbidity and mortality, most importantly drowning. This review describes the epidemiology, type, and location of injuries across paddle sports. It not only focuses on whitewater injuries but also includes information on injuries sustained in other aquatic paddling environments.
QUARTIC: QUick pArallel algoRithms for high-Throughput sequencIng data proCessing
Authors: Jarlier Frédéric , Joly Nicolas , Fedy Nicolas , Magalhaes Thomas , Sirotti Leonor , Paganiban Paul , Martin Firmin , McManus Michael , Hupé Philippe
Published: October 2020

Life science has entered the so-called 'big data era' where biologists, clinicians and bioinformaticians are overwhelmed with high-throughput sequencing data. While they offer new insights to decipher the genome structure they also raise major challenges to use them for daily clinical practice care and diagnosis purposes as they are bigger and bigger. Therefore, we implemented a software to reduce the time to delivery for the alignment and the sorting of high-throughput sequencing data.  Our solution is implemented using Message Passing Interface and is intended for high-performance computing architecture. The software scales linearly with respect to the size of the data and ensures a total reproducibility with the traditional tools. For example, a 300X whole genome can be aligned and sorted within less than 9 hours with 128 cores. The software offers significant speed-up using multi-cores and multi-nodes parallelization.
The Level of Maternal Knowledge about Complications in Pregnancy toward the Increase of Low Birth Weight Cases
Authors: Aryani Aisyah Apriliciciliana , Besral Besral
Published: October 2020

Background: Based on Metro City Health Office reports, there was an increase in the proportion of LBW cases from 75 cases per 1.000 live births in 2015 to 87 cases per 1.000 live births in 2016. Metro City Health Service stated that one of the causes was the low level of maternal knowledge, especially regarding the consumption of balanced nutrition during pregnancy. This study aimed to investigate the relationship between the level of maternal knowledge and Low Birth Weight (LBW). Method: The study design was case-control, where low birth weight as a case and normal weight as a control. Study sample was 102, consisting of 51 cases and 51 control. Dependent variable was low birth weight, independent variable was the level of maternal knowledge. Data was obtained by interviewing the mothers, and secondary data was collected from community health center records. Data was analysed by bivariate and multivariate analysis. Results: Bivariate analysis showed that the OR level of maternal knowledge was 2,598 (95% CI: 1,126-5,995). The results of multivariate analysis showed that OR level of maternal knowledge was 2,646 (95% CI: 1,092-6,410). Conclusion: Mother's level of knowledge is a risk factor for LBW in Metro City.
The Relation Between Physical Activities and the Occurrence of Dysmenorrhea
Authors: Fatimah Adinda Dwi Beauty , Rohmah Fayakun Nur
Published: October 2020

Background: According to a research conducted in Palestine, there are 85.1% university students reportedly having pain during menstruation. The occurrence of dysmenorrhea in Indonesia is 86%. The high occurrence of dysmenorrhea has less attention from the public and even from the adolescents themselves. One of the factors that influence the occurrence of dysmenorrhea is physical activities. Women who do not do exercise regularly have 3.48 times of risk to experience dysmenorrhea. This study aims to reveal the correlation between physical activities and dysmenorrhea. Method: This was quantitative research with cross sectional design. The population in this study was 136 female students of D4 Medical Laboratory Technology study program. Sixty eight respondents were contributed in this study with exclusion and inclusion criteria. The sampling technique used was total sampling. Bivariate analysis used was the Fisher’s Exact correlation test. The research hypothesis was there was a correlation between physical activities and the occurrence of dysmenorrhea. Results: There were 51 respondents who experienced dysmenorrhea (75%) and there were 53 respondents who were categorized at moderate physical activities obtained p < 0.05). Conclusion:  It can be concluded that there is a relation between physical activities and dysmenorrhea
Commuting Mobility as Risk Factor for Dengue Hemorrhagic Fever in Sleman Regency, Yogyakarta, Indonesia
Authors: Kesetyaningsih Tri Wulandari , Amir Siti Fajrini , Desty Yeni Rahma
Published: October 2020

Background:In Indonesia, there has been a change in the age group of dengue hemorrhagic fever (DHF) patient population from children to adults since 1998. It raises the suspicion that an infection occurs not only in residential area but also from other places as a result of human mobility. Research on the role of people mobility as a risk factor for dengue incidence yielded different results. This study aims to reveal the relationship between human mobility and the incidence of dengue. Method: This is a case-control study that involved 276 respondents; 138 were sufferers (case group) while the other 138 respondents were non-sufferers (control group). The sample size was determined by using purposive sampling. Patient’s data and their addresses were obtained from Sleman Regency Health Office while the control group was patient’s neighbors. The people mobility data were obtained by conducting questionnaires that were divided into three categories, namely low, moderate, and high for commuting mobility and two categories, namely traveling outside and inside province for circular mobility. Chi-square analysis was used to determine whether mobility was a risk factor for DHF. Results:The result showed that commuting mobility was correlated with the DHF incidence (p=0.001) where the high mobility of 3.169 times raised the risk of DHF incidence (OR 3.169; 95% CI: 1.690-5.944) more than the low mobility. However, the DHF incidence was not correlated with moderate mobility (p=0,821). Furthermore, traveling outside the Yogyakarta Province reduced the risk by 6.175 times than non-traveling activity (p=0.000; OR 6.175; 95% CI: 2.759-13.822). Conclusion: The commuting mobility outside the village is a risk factor of DHF. Meanwhile, traveling outside Yogyakarta Province did not cause any risk for DHF and it instead tended to reduce the risk.
Oral conditions in the community patient: part 1
Authors: Archer Natalie , Martin Katy , Johnston Laura
Published: October 2020

Oral health is essential to prevent pain, ensure adequate nutrition and promote optimum general and psychosocial wellbeing. The detrimental effects of poor oral health can often be overlooked, resulting in low prioritisation of oral care when compared to other care roles. A multidisciplinary approach to maintaining good oral health of dependent community patients must be established, with stakeholders including dentists, nurses, carers, and family members. This article aims to explore fundamental oral health considerations for community nurses to maintain oral health.
Production of the electronic British Lymphology Society Red Legs Pathway
Authors: Elwell Rebecca
Published: October 2020

Antibiotic misuse is a rampant problem the world over and it in turn leads to other issues, the main one being the rise of antibiotic-resistant microorganisms. Often, bilateral red legs are mistaken for acute cellulitis, an infection of the skin, and are inappropriately treated with antibiotics. The British Lymphology Society's Red Legs Pathway aims to support differential diagnosis in patients with bilateral red legs to enable prompt and effective management and improve patient experience. The pathway also aims to reduce inappropriate use of antibiotics and potential negative consequences. This article provides a brief outline of the pathway and its development.
Using thermal imaging to measure changes in breast cancer-related lymphoedema during reflexology
Authors: Whatley Judith Anne , Kay Sally
Published: October 2020

Reflexology lymph drainage (RLD) for breast cancer-related lymphoedema (BCRL) may have a positive impact on arm swelling and pain. Thermal imaging is a means of tracking temperature change by visual images. This study aimed to explore the use of thermal imaging in treatment for BCRL. The swollen arms of two participants with BCRL were photographed using a thermal imaging camera during a single RLD treatment. Limb Volume Circumferential Measurement (LVCM) of both arms was taken before, after and the next day. The images were examined for visual changes, and temperature data were extracted. Images showed differences in temperature within the affected hand and arm over 45 minutes. LVCM data indicated a loss of limb volume in the affected arm in both cases, which continued to decrease over 24 hours. Thus, thermal imaging may be useful in tracking temperature change during treatment for BCRL.
Supporting families after a diagnosis of Edwards' or Patau's syndrome
Authors: Fowler Jan
Published: October 2020

Trisomy 13 and 18 are increasingly common, and many affected pregnancies do not survive past the second or third trimester. SOFT UK works to support affected individuals and their families
Birth trauma: the mediating effects of perceived support
Authors: Baptie Grace , Andrade Jackie , Bacon Alison M. , Norman Alyson
Published: October 2020

Background

Many women experience their childbirth as traumatic, and 4-6% of mothers present with postnatal post-traumatic stress disorder.

Aims

To measure the relationship between obstetric intervention, perceived support in childbirth and mothers' experiences of postnatal trauma, and to identify salient aspects of the birth experience that are considered traumatic.

Methods

A total of 222 women in their first year postpartum were recruited between October and December 2018 via local mother and baby groups in southwest England (UK) and online social media pages. They completed an online survey regarding their birth experience. Further insight into mother's birth experiences was garnered through free-text responses in the survey.

Results

Overall, 29% of mothers experienced a traumatic birth and 15% met full or partial criteria for post-traumatic stress disorder. Feeling supported mediated the relationship between obstetric intervention and postnatal trauma symptoms.

Conclusions

This study reinforces the value of supportive healthcare professionals and the power of a nurturing environment, which can buffer the potentially negative effects of an obstetrically complicated birth on postnatal trauma symptoms.
Families of Estimators for Estimating Mean Using Information of Auxiliary Variate Under Response and Non-Response
Authors: Sinha R. R. , Bharti
Published: October 2020

This research article is concerned with the efficiency improvement of estimators for finite population mean under complete and incomplete information rising as a result of non-response. Different families of estimators for estimating the mean of study variate via known population mean, proportion and rank of auxiliary variate under different situations are proposed along with their bias and mean square error (MSE). Optimum conditions are suggested to attain minimum mean square error of proposed families of estimators. Further the problem is extended for the situation of unknown parameters of auxiliary variate and two phase sampling families of estimators are suggested along with their properties under fixed cost and precision. Employing real data sets, theoretical and empirical comparisons are executed to explain the efficiency of the proposed families of estimators.
NUTRITIONAL STATUS OF CORN PLANTS ESTIMATED THROUGH DIFFERENT VEGETATION INDICES IN THE GROWTH STAGES
Authors: Diaz de Carvalho Luiz Felipe , Amado Telmo Jorge Carneiro , Sobrinho José Cardoso , Amaral Lúcio de Paula , Pott Luan Pierre , Piccin Marcieli , Pedron Vinícius Freitas
Published: October 2020

Several vegetation indices (VIs) have been proposed in the literature with the objective of exploring the spectral properties of the vegetation as they are usually related to biophysical parameters of the plants. The objective of this study was to evaluate the relationship between VIs, obtained in two different RPAS platforms (Remotely-piloted spacecraft system) and proximity system at different corm growth stages with the nitrogen (N) nutritional status in the plant. Five treatments with different nitrogen fertilizer rates (20, 60, 120, 180 and 240 kg ha-1) were studied in order to generate the variability of nitrogen uptake by the plant in four blocks with five replicates each. Reading of the following VIs were performed: NDRE and NDVI (proximity sensing, Optrix sensor) and NDRE, NDVI, EVI2 and GNDVI (RPAS platform, MicaSense Parrot Sequoia sensor) at the phenological stages V5, V6, V7, V9, V11 and V12. Corn plants were collected to evaluate N content in the aerial part of the plant. The N content was higher in V7 growth stage and lower in V12 stage. The VIs obtained through the RPAS platform presented higher relationship with the corn nutritional status when compared to the proximity sensors. The V12 corn growth stage had higher relationship of VIs and plant N content in comparison to the proximity sensor.
Coating film and asymmetric amplitude difference effects on measurement performance in phase grating interference-based metrology
Authors: Zhang Tao , Sun Tao , Li Jiean , Zhao Xingyu , Cui Jiwen , Tan Jiubin
Published: October 2020

In this study, the effects of the coating film thickness on a grating interferometry system were analyzed. The asymmetry-induced error of the deformed phase grating varied periodically with the coating film thickness, due to the spurious interference of multiple reflections in the film layer and asymmetry in the amplitudes of the diffraction orders, which led to phase offsets (and thus position errors). The average error obtained with a multiorder interferometer was compared to that simulated by atomic force microscopy. The simulation and measurement results were consistent with the theoretical analysis, which will facilitate accurate measurement error analysis.
The Edward Hartley Angle Society of Orthodontics (EHASO)
Authors: Rodrigues de Almeida Marcio
Published: October 2020

Todos nós, ortodontistas, conhecemos um pouco da história de um dos maiores nomes da Ortodontia moderna, Edward Hartley Angle, quer seja durante o curso de graduação, por meio da sua famosa classificação das más oclusões datada de 18991 , quer na pós-graduação, pelo desenvolvimento do Aparelho Edgewise (1928)2 . Mas o que nem todos sabem é que existe uma Sociedade, criada há 90 anos, com o propósito de perpetuar o idealismo, os ensinamentos e o legado de Angle: a Edward Hartley Angle Society of Orthodontics (EHASO). Este editorial tem o fim precípuo de fazer uma reflexão acerca dessa nobre sociedade.
Carlos Eduardo Ferreira
Authors: Brandão Roberto Carlos Bodart , Pignaton Tulio Bonna , Valladares Netto José , Artese Flavia
Published: October 2020

Para abrilhantar esse número, a Clin Orthod entrevista, pela primeira vez, um profissional não ligado diretamente à Ortodontia, e terei o privilégio de apresentá-lo aos leitores. Carlos Eduardo de Almeida Ferreira é um periodontista e implantodontista padrão-ouro que, como poucos, trabalha em sinergia com ortodontistas, o que o torna uma referência para aqueles que acreditam na multidisciplinaridade como fator essencial ao sucesso. É filho de Dona Joana e Carlos Urbano Gonçalves Ferreira (ambos in memoriam), funcionários públicos que vieram do Rio de janeiro para construir em Vitória uma bela família com quatro filhos. O pai, conhecido como “Carioca”, transformou-se em uma lenda como instrutor de natação e formatou alguns campeões, como o próprio filho e nosso entrevistado, o que explica o seu perfil de líder, sua busca pela técnica perfeita e apurado senso crítico. Não apenas campeão nas piscinas, nosso entrevistado foi, também, um grande agregador de amigos desde sua adolescência, uma referência de “boa praça”. Eu o conheci nessa época: era o “Duzinho”. Brilhante aluno, fez Odontologia na UFES, graduando-se em 1985. Depois, ingressou no Mestrado em Periodontia na UFRJ, concluído em 1988, quando iniciou sua clínica particular. Mesmo como um expoente periodontista de nossa cidade, não estava satisfeito. Foi, então, aprovado, e iniciou sua trajetória internacional como Post Doctoral Fellow (Oral Biology) da State University of New York, em Buffalo, onde também atuou como Professor Associado de Periodontia nos anos 1995 e 1996. Também se preparou para a pesquisa científica no Summer Institute na Washington University, com treinamento específico para projetos, interpretação e avaliação de pesquisas e artigos científicos. Retornando ao Brasil, Carlos Eduardo tornou-se uma referência como periodontista e também como pesquisador, com vários artigos publicados, além de ter se habilitado na, então, recente especialidade de Implantodontia.
Praticidade em realizar desoclusão dentária em casos de protração maxilar com sobremordida exagerada
Authors: Caldas Luciana Duarte , Barretos Luísa Schubach da Costa , Galisteu Luiz Kelly , Nojima Lincoln Issamu
Published: October 2020

INTRODUÇÃO: A má oclusão de Classe III pode ser tratada ortodonticamente na fase da dentição mista. Contudo, outros tipos de más oclusões associadas, como a sobremordida exagerada, podem agravar a severidade do caso. Diante disso, a necessidade da utilização da máscara facial fica comprometida pela ausência de uma dimensão vertical livre suficiente que compense esse trespasse vertical acentuado, dificultando, dessa forma, a protração da maxila e consequente descruzamento dentário anterior. Como solução, torna-se bastante comum a confecção e cimentação de batentes de desoclusão posterior fixos. Mas e quando não há suporte dentário posterior satisfatório para permitir a instalação desses batentes? O que fazer? OBJETIVO: O objetivo do presente artigo foi descrever como obter desoclusão posterior para o tracionamento maxilar na fase da dentição mista, nos casos com sobremordida exagerada associada e poucos elementos dentários na região posterior.
Razões para se remover os terceiros molares não irrompidos ou parcialmente irrompidos
Authors: Consolaro Alberto , Hadaya Omar , Cardoso Mauricio de Almeida
Published: October 2020

INTRODUÇÃO: Os terceiros molares, quando não estão em oclusão, representam uma fonte de problemas, como reabsorções nos segundos molares e/ou em sua própria estrutura, pericoronarites, cisto paradentário, outros cistos e neoplasias odontogênicas. Quando parcialmente irrompidos, são portas de entrada para microrganismos e isso pode comprometer a saúde geral dos pacientes, especialmente aqueles com alguma doença sistêmica, independentemente da idade. CONCLUSÃO: A extração desses dentes antes do tratamento ortodôntico é uma forma de prevenir os problemas clínicos que podem deles advir e interferir na sequência terapêutica planejada.
Tratamento ortodôntico interceptivo: da manutenção de espaço à estabilidade no acompanhamento
Authors: Allgayer Susiane , Bertoglio Celso Renato Sartori
Published: October 2020

OBJETIVO: O objetivo do presente artigo foi relatar um caso clínico no qual o conhecimento sobre o crescimento da face e desenvolvimento da dentição possibilitou o redirecionamento favorável do crescimento em uma menina com perfil côncavo já aos 6 anos e 2 meses de idade. RESULTADOS: Por meio de expansão maxilar, manejo adequado do Leeway space durante a dentição mista e uso de aparelho extrabucal, conseguiu-se resolver o problema de discrepância de perímetro da arcada, dissolvendo o apinhamento sem necessidade de exodontias. CONCLUSÃO: Apesar do tempo mais longo de tratamento, o resultado estável em longo prazo, sorriso agradável e face equilibrada reforçam as condutas preventivas e interceptativas.
Experiences of prospective social studies teachers in project-based values education
Authors: Seçgin Fadime
Published: October 2020

This study, aiming to reveal the experiences of prospective social studies teachers on project-based values education, was carried out in phenomenological design, which is one of the qualitative research designs. The study group consisted of 37 second-year students who received values education as an elective course in the social studies teaching department of a public university and who carried out projects for the values that they determined within the scope of the course. To create a project, the prospective teachers chose values such as equality, responsibility, sensitivity (cultural heritage), helpfulness, attaching importance to being healthy, patriotism, and savings. They implemented their projects on these values to the groups that they found appropriate. At the end of the process, a semi-structured interview form was used as data collection tool to reveal the participants' experiences of project-based values teaching. Descriptive analysis and content analysis were used to analyze the study data. As a result of the study, we concluded that the participants selected the values for their projects for reasons such as “raising awareness on the related values, embodying abstract values, eliminating prejudices, emphasizing the importance of cooperation in society”. Project-based values education was observed to provide the participants with many advantages such as “provision of experience both for values education and the teaching profession, project planning and conduction, improving communication skills, developing a sense of spirituality.”
Autologous Hematopoietic Stem Cell Therapy of the Subjects with Systemic Sclerosis: Electromyographic Results of the Masticatory Muscles
Authors: Branco Thamyres , Oliveira Ligia Franco , Palinkas Marcelo , de Vasconcelos Paulo Batista , Oliveira Maria Carolina , Simões Belinda Pinto , Regalo Isabela Hallak , Siéssere Selma , Regalo Simone Cecilio Hallak
Published: October 2020

Musculoskeletal system impairment is a major cause of functional alterations in subjects with systemic sclerosis. Autologous hematopoietic stem cell therapy (AHSCT) may have an important role in the treatment functional of systemic sclerosis patients. The aim of this pilot study was to assess whether AHSCT interferes with the electromyographic activity of the masseter and temporalis muscles of subjects with systemic sclerosis. Before transplantation, seven subjects with systemic sclerosis (mean age [± SD], 40.1 ± 9.6 years) underwent electromyographic analysis of the masseter and temporalis muscles in mandibular tasks at rest, right and left laterality, protrusion and maximum voluntary contraction. Two months after AHSCT, the subjects re-evaluated using the same methods. Data were analyzed using the repeated-measure test, with p<0.05 considered to be statistically significant. Two months after AHSCT, there was reduction in normalized electromyographic activity in the dental clenching in maximal voluntary contraction, with significant differences, for the left temporal muscle (p=0.04). AHSCT in subjects with systemic sclerosis promotes alterations in stomatognathic system function, especially those related to electromyographic activity of masticatory muscles.
On three-variable expanders over finite valuation rings
Authors: Ham Le Quang , Van The Nguyen , Tran Phuc D. , Vinh Le Anh
Published: October 2020

Let

ℛ

{\mathcal{R}}

be a finite valuation ring of order

q
r

{q^{r}}

.
In this paper, we prove that for any quadratic polynomial

f
⁢

(
x
,
y
,
z
)

∈

ℛ
⁢

[
x
,
y
,
z
]

{f(x,y,z)\in\mathcal{R}[x,y,z]}

that is of the form

a
⁢
x
⁢
y

+

R
⁢

(
x
)

+

S
⁢

(
y
)

+

T
⁢

(
z
)

{axy+R(x)+S(y)+T(z)}

for some one-variable polynomials

R
,
S
,
T

{R,S,T}

, we have

|

f
⁢

(
A
,
B
,
C
)

|

≫

min
⁡

{

q
r

,

|
A
|

⁢

|
B
|

⁢

|
C
|

q

2
⁢
r

-
1

}

|f(A,B,C)|\gg\min\biggl{\{}q^{r},\frac{|A||B||C|}{q^{2r-1}}\bigg{\}}

for any

A
,
B
,
C

⊂
ℛ

{A,B,C\subset\mathcal{R}}

.
We also study the sum-product type problems over finite valuation ring

ℛ

{\mathcal{R}}

. More precisely, we show that for any

A
⊂
ℛ

{A\subset\mathcal{R}}

with

|
A
|

≫

q

r
-

1
3

{|A|\gg q^{r-\frac{1}{3}}}

then

max
⁡

{

|

A
⁢
A

|

,

|

A
d

+

A
d

|

}

{\max\{|AA|,|A^{d}+A^{d}|\}}

,

max
⁡

{

|

A
+
A

|

,

|

A
2

+

A
2

|

}

{\max\{|A+A|,|A^{2}+A^{2}|\}}

,

max
⁡

{

|

A
-
A

|

,

|

A
⁢
A

+

A
⁢
A

|

}

≫

|
A
|

2
3

⁢

q

r
3

{\max\{|A-A|,|AA+AA|\}\gg|A|^{\frac{2}{3}}q^{\frac{r}{3}}}

,
and

|

f
⁢

(
A
)

+
A

|

≫

|
A
|

2
3

⁢

q

r
3

{|f(A)+A|\gg|A|^{\frac{2}{3}}q^{\frac{r}{3}}}

for any one variable quadratic polynomial f.
A partial inverse problem for quantum graphs with a loop
Authors: Guan Sheng-Yu , Yang Chuan-Fu , Wu Dong-Jie
Published: October 2020

We consider the Sturm–Liouville operator on quantum graphs with a loop with the standard matching conditions in the internal vertex and the jump conditions at the
boundary vertex. Given the potential on the loop, we try to recover the potential on the boundary edge from the subspectrum. The uniqueness theorem and a constructive
algorithm for the solution of this partial inverse problem are provided.
Enhancing confidentiality protection for ZCZ-OCDMA network using line selection and wavelength conversion based on SOA
Authors: Ouis Esma , Driz Samia , Fassi Benattou
Published: October 2020

The physical layer of an optical network is vulnerable towards various types of security threats such as physical infrastructure attacks and eavesdropping, where the security item requires more attention in front of the dramatically grows in network capacity. In this paper, authors propose a comparison in performance of zero correlation zone-Optical Code Division Multiple Access based on different confidentiality mechanisms implemented using existing optical logic components such as line selectors, wavelength convertors and XOR gates. The performance of the proposed designs in terms of log of the bit error rate (BER) as function of the received power was evaluated through OptiSystem software simulation. The achieved results demonstrate that design 3 is the best confidentiality solution in terms of received power, BER performance and architecture complexity.
Touching taste: The classist intersections of materiality, textuality and tactility
Authors: Thurlow Crispin
Published: October 2020

Contemporary class formations increasingly exceed language and, therefore, defy the usual word-centric, text-based approaches of discourse studies. As Bourdieu famously observed, class-sustaining enactments of distinction and taste are often enacted outside language through banal “techniques of the body” such as people’s ways of walking or ways of eating. In this vein, my paper presents a social-semiotic analysis of the particular role menus play in materializing taste, both gustatory and social. However, rather than taking the obvious tack of addressing their linguistic content or typographic design, I focus on their haptic, experiential properties; for example, their shape, size, weight, density and other textural, tactile or material features. As a critical-empirical focus, my core evidence is an archive of Business Class menus from 18 international airlines; it is here that eating practices are explicitly framed as distinctive and superior. The significance of any text cannot be properly understood by simply attending to its straightforwardly representational meanings; its sensory and sensuous materialities must be addressed too. This, I propose, is where some of the most subtle but powerful status-making happens – the seemingly harmless, throw-away moments where privilege/inequality arises, invariably obscured but assuredly naturalized.
Errors in multiple variables in human immunodeficiency virus (HIV) cohort and electronic health record data: statistical challenges and opportunities
Authors: Shepherd Bryan E. , Shaw Pamela A.
Published: October 2020

Objectives: Observational data derived from patient electronic health records (EHR) data are increasingly used for human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) research. There are challenges to using these data, in particular with regards to data quality; some are recognized, some unrecognized, and some recognized but ignored. There are great opportunities for the statistical community to improve inference by incorporating validation subsampling into analyses of EHR data.Methods: Methods to address measurement error, misclassification, and missing data are relevant, as are sampling designs such as two-phase sampling. However, many of the existing statistical methods for measurement error, for example, only address relatively simple settings, whereas the errors seen in these datasets span multiple variables (both predictors and outcomes), are correlated, and even affect who is included in the study.Results/Conclusion: We will discuss some preliminary methods in this area with a particular focus on time-to-event outcomes and outline areas of future research.
Nonlinear rarefactive isothermal ion acoustic waves in magnetized ultrarelativistic degenerate plasmas
Authors: El-Shamy Emad F. , Selim Mustafa M. , El-Depsy Alya , Mahmoud Mona , Al-Hagan Ola , Al-Mogeeth Abdulaziz
Published: October 2020

Nonlinear rarefactive isothermal ion-acoustic periodic travelling waves (RIIAPTWs) are examined in a magnetized ultrarelativistic degenerate plasma, containing warm fluid ions and ultrarelativistic degenerate inertialess electrons as well as positrons and immobile heavy negative ions. In the linear regime, the excitation of an isothermal ion-acoustic mode and its evolution are investigated. The physical behavior of nonlinear rarefactive isothermal ion-acoustic waves (RIIAWs) in this plasma model is governed by a Zakharov–Kuznetsov (ZK) equation. The analytical solutions for the nonlinear rarefactive isothermal ion-acoustic solitary waves (RIIASWs) and RIIAPTWs are performed by the bifurcation analysis. A careful discussion demonstrates the excitations of RIIASWs and RIIAPTWs are amplified (i.e., the amplitudes become deeper), as the chemical potential (or the Fermi energy at zero temperature) of electrons is decreased. It is found physically that the presence of the ultrarelativistic degenerate positrons and stationary heavy negative ions have strong effects on features of nonlinear RIIASWs and RIIAPTWs. The implications of the present finding in compact astrophysical objects, such as white dwarf stars, have been discussed.
Catalytic removal of methylene blue with different stoichiometric ratios of ZnCuS nanoparticles
Authors: Mehrabian Masood , Afshar Elham Norouzi
Published: October 2020

Photocatalytic decomposition of methylene blue (BM) solution by Cu-doped ZnS nanoparticles in the presence of UV light has been studied. The effect of the molar ratio of Cu ions affecting the rate of degradation reaction has been investigated. Photocatalytic reactivity of ZnS:Cu nanoparticles could be tailored by the proper amount of Cu ions. The maximum decolorizing efficiency (85%) of 5 ppm MB was obtained by 30 mgL−1 nanoparticles containing 2 wt% Cu, which was ascribed to the most effective surface area of these particles. However, at more than 2 wt% Cu doping concentration, nanoparticles aggregated due to their high surface energy, and the decomposition efficiency was decreased.