bluuebunny/crossref_metadata_2025 huggingface dataset:
A Patient perspective of Complementary and Integrative Medicine (CIM) for Migraine Treatment: A social media survey
Authors: Kuruvilla Deena E , Mehta Amit , Ravishankar Nidhi , Cowan Robert
Published: May 2020

OBJECTIVE: To survey persons with migraine who use social media about Complementary and Integrative Medicine (CIM) for the treatment of migraine.BACKGROUND: CIM encompasses medical treatments that are not part of ,but are used in concert with, mainstream medicine. Between 28–82% of people with migraine use non-drug approaches, and approximately 50% of people with migraine do not discuss non-drug treatments with their healthcare providers (HCPs) 9. it is important for providers to be conversant with CIM treatments and the available evidence-based data. To further this effort, the Complementary and Integrative Medicine Special Interest Section (CIMSIS) of the American Headache Society surveyed migraine patients directly through social media to identify CIM practices in which they engage.METHODS: In collaboration with the American Migraine foundation (AMF) and Yakkety Yak, a digital marketing agency, we posted a 17-question survey on the Move Against Migraine (MAM) Facebook group, which has 20,000 + members. The goals of the survey were to assess the attitudes toward CIM among this group, to identify which CIM modalities are being used and to determine what patients considered to be the most effective CIM modalities. While Yakkety Yak posted the survey link on the group page, the survey itself was hosted on Qualtrics, a confidential survey service. Qualtrics provides tools to configure survey properties and to customize privacy settings, so respondents cannot be tracked to an IP or email address, name or ticket number, which allows for anonymous responses. Our study was submitted for review to the IRB (institutional review board) and was exempted.RESULTS: 372 MAM members (approximately 2%) responded to the questionnaire, of which 335 reported using CIM; between 114–139 (34–42%) found CIM modalities to be at least mildly effective. Of note, 164 (49%) reported using cannabis derivatives or cannabinoids, specifically with, 64/164 (39%) reporting that cannabis was not effective for them.CONCLUSIONS: This study provides an initial investigation into the demographic and practice patterns of patients who use CIM. While it must this sampling may not reflect CIM use across all individuals with migraine, it does strongly suggest the need for better education on the role of, and evidence for, CIM among headache care providers, and the need to ask patients specifically about their use of and interest in CIM.
LncRNA IMFlnc1 promotes porcine intramuscular adipocyte differentiation by sponging miR-199a-5p to up-regulate CAV-1
Authors: Wang Jing , Chen Junfeng , Chen Mingyue , Hua Liushuai , Ren Qiaoling , Zhang Jiaqing , Cao Hai , Bai Xianxiao , Pan Chuanying , Xing Baosong
Published: May 2020

Background Local Chinese local pig breeds have better meat quality, such as thinner muscle fiber and higher intramuscular-fat (IMF) content. However, its molecular regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (lncRNAs) participate in the regulation of muscle and fat development. The expressional differences of lncRNAs in the longissimus dorsi (LD) muscle were identified between Huainan pigs (local Chinese pigs, fat-type, HN) and Large White pigs (lean-type, LW) at 38, 58, and 78 days post conception (dpc).Results In total, 2131 novel lncRNAs were identified in 18 samples, and 291, 305, and 683 differentially expressed lncRNAs (DELs) were found between these two breeds at three stages, respectively. GO and KEGG analysis of the DEL co expressed mRNAs showed that muscle development and energy metabolism were more active at 58 dpc in HN, but at 78 dpc in LW pigs. Muscle cell differentiation and myofibril assembly might contribute to earlier myogenesis and primary-muscle-fiber assembly in HN, and cell proliferation, insulin, and the mitogen-activated protein kinase (MAPK) pathway might contribute to longer proliferation in LW pigs. The PI3K/Akt and cAMP pathways were associated with higher IMF deposition in HN. IMFlnc1 was selected for functional verification, and results indicated that it regulated the expressional level of caveolin-1 (CAV-1) as a competing endogenous RNA (ceRNA) for miR-199a-5p.Conclusion Our data contributed to understanding lncRNAs in porcine-muscle development and IMF deposition, and provided valuable information for improving pig-meat quality.
Geographic and Socioeconomic Disparities in Nutritional Status of Women in Pakistan: Secondary Analysis from Pakistan National Nutrition Survey
Authors: Sadiq Kamran , Mahmood Bushra , Kureishy Sumra , Ariff Shabina , Mustafa Ghulam , Khan Gul Nawaz , Umer Muhammad , Memon Zahid , Janjua Naveed , Soofi Sajid , Bhutta Zulfiqar A
Published: May 2020

Background: Pakistan is experiencing a rapid nutrition transition with a shift from underweight to overweight and obesity. This paper will examine the role of household socioeconomic position (SEP), community SEP and urbanicity on the nutritional status (underweight, overweight and obesity) of Pakistani women. Methods: We analysed data on 34,391 women aged ≥20 years enrolled in 2011 National Nutritional Survey of Pakistan (NNS). The NNS is a nationally representative survey employing a multistage stratified cluster sampling design. We assessed household SEP through a wealth index constructed using items from household possessions, utilities and housing conditions. We assessed the relationship of urbanicity, household and community SEP with categories of body mass index (BMI) using multinomial logistic regression where normal BMI (18.6-22.5 kg/m 2 ) was the reference category. Results: Overall, 15% of women were underweight (BMI<18.5 kg/m 2 ), 14% were pre-overweight (BMI 23.00-24.9 kg/m 2 ), 22% were overweight (BMI 25.0-29.99 kg/m 2 ) and 12% were obese (BMI≥30.0 kg/m 2 ). Households with higher SEP were associated with increased levels of overweight-1 (aOR: 2.91; 95%CI: 2.41-3.50), overweight-2 (aOR: 4.15; 95%CI: 3.31-5.19) and obesity (aOR: 6.20; 95%CI: 4.92-7.81) among women. Women were more likely to be obese in major urban (aOR: 2.34; 95%CI: 2.02-2.71) and urban (aOR: 1.84; 95%CI: 1.62-2.09) areas compared to rural areas. At the community level, communities in rural areas were more likely to have higher levels of underweight, while communities in urban areas were more likely to have higher levels of obesity. Furthermore, the likelihood of underweight and overweight women coexisting within the same community was low in major urban (r=0.67), urban (r=0.55) and rural (r=0.54) areas. Conclusions: In Pakistan, overweight and obesity among women is associated with urbanicity and household and community SEP. Women living in urban areas with high household and community SEP were associated with higher levels of overweight and obesity. Our findings suggest the importance of interventions targeting undernutrition in rural areas and overnutrition in urban areas.
Travelling and COVID-19: A Mathematical Model
Authors: Banerjee Sankha
Published: May 2020

A non-linear mathematical model is proposed to study the impacts of travelling in human-human transmission of COVID- 19.Two different regions are considered and transmission dynamics of COVID-19 dissemination in two regions caused by travelling from one region to other and infection during travel are discussed.Besides contacts between susceptible and infected population of a region off the travel,transmission of disease due to contacts during travel is also considered.The proposed model is analysed using stability theory of ordinary differential equation and feasibility of qualitative results ia checked through numerical simulations.From obtained results,it is shown that travelling and population dispersal can aggravate disease spreading in each region.It is also inferred that rate of travelling and rate of contacts during travel and off the travel can ease the disease to take endemic form and for high rates,it may become pandemic. Further numerical calculations are performed and critical limits of the major factors enhancing spreading of disease.It is revealed that when the rates goes higher than their corresponding critical limits,disease may not be controlled due to high infection.It is also imparted that when the rates are high, disease can only be controlled with high rate of quarantine.Also approximate time or stability is evaluated for maximum as well as minimum rates of key parameters.The results obtained by analyzing the model recommends that for early stability of endemic situation, key factors must be kept as minimum as possible within estimated limits and quarantining infected class to control the transmission of disease.
Computational studies on Gene Ontology for Molecular functions, Cellular component and Biological process of SARS-CoV-2 targeted proteins
Authors: Manikyam Hemanth kumar
Published: May 2020

World is facing pandemic COVID-19 caused by SARS-CoV-2.Researchers are working to identify potential cure and treatment for COVID-19. Many Repurposed drugs been proposed to treat the infection with good success rate in some cases. But still there is an urgency to discover potential cure and treatment. In order to discover potential cure we should understand the Gene Ontology of targeted proteins of SARS-CoV-2 for their Molecular functions, cellular component and Biological process. Spike glycoproteins, Main protease (Mpro), Papain like protease (PLpro) are three main proteins that aid viral host cell entry and its replication causing pathogenesis. Using MetaGO an algorithm an algorithm for predicting Gene Ontology (GO) of proteins the Molecular functions, Cellular component and Biological process of SARS-CoV-2 proteins studied. MetaGO analysis had predicted Spike protein gene ontology functions include host cell surface binding, receptor binding, host cell surface receptor binding, structural molecule activity, carbohydrate binding. Main Protease (Mpro) and Papain like protease (PLpro) gene ontology functions predicted hydrolase activity, RNA-directed RNA polymerase activity, ubiquitinyl hydrolase activity, Lys48-specific deubiquitinase activity, mRNA (nucleoside-2'-O-)-methyltransferase activity, mRNA (guanine-N7-)-methyltransferase activity, double-stranded RNA binding, 3'-5'-exoribonuclease activity, helicase activity, single-stranded RNA binding, cysteine-type endopeptidase activity, omega peptidase activity, zinc ion binding, thiol-dependent ubiquitinyl hydrolase activity, ATP binding, endonuclease activity among which PLpro had shown inhibition of ISG15 activity in additional. Inhibition of ISG15 indicates down regulation of interferon production particularly Interferon Type 1. PYCR1 (Pyrroline-5-carboxylate reductase 1) which protects the cells from mitochondrial damage due to oxidative stress shown to be inhibited by Spike protein hydrolase like activity and leading to cell death.PYCR1 can be a diagnostic tool to detect novel coronavirus infection. Viral proteins also use cellular Ubiquitinyl enzymes for its replication and survival in host cell. Thus through gene ontology studies we propose use of Interferon type 1 therapy against COVID-19 caused by SARS-CoV-2.
Appraisal Framework in Analyzing Learners’ Attitudinal Resources on Performing Of Mice and Men
Authors: Pasaribu Truly Almendo
Published: May 2020

This paper is carried out to find out the attitudinal resources used by students in Play Performance class through appraisal framework (Martin & White, 2005). It focuses on how the students negotiate attitudes to express their feelings, judgements, and appreciation of “Of Mice and Men” production process. The data for this qualitative study were collected from students’ reflections which were selected purposely from different production and artistic divisions. It analyses 109 expressions based on three domains of attitudinal resources in the appraisal theory. The most frequently used resources are affect resources that serve to express students’ positive or negative feelings. The findings show that although students experience a certain degree of insecurity [-security], they reveal positive inclination [+inclination] towards the production process. The judgement and appreciation resources are used to evaluate the behavior and learning processes. The discussion demonstrates that this systemic functional linguistic framework works as a solid basis to analyze students’ reflections. This study implies that the appraisal framework can be one of the considerations in evaluating learners’ performance.
Addressing Unemployment challenge through micro and small enterprises (MSEs): Evidence from Nigeria
Authors: Matthew Oluwatoyin , E. Ufua Daniel , Osabohien Romanus , Olawande Tomike , D. Edafe Oluwatosin
Published: May 2020

This study examined the operational characteristics of MSEs and their contributions towards addressing the national challenge of unemployment. The research was based on Ado-Odo/Ota Local Government Area in Ogun State, Nigeria. The study employed descriptive analysis and Ordinary Least Square (OLS) regression technique in estimating the data obtained. The administration of questionnaire was applied to collect the data. The study found out that micro and small-scale enterprises contributed to economic growth through their operational activities, via the job creation in the economy. Thus, the study recommended that government policies should be put in place to encourage micro and small enterprises, and the provision of infrastructures, credit facilities, tax holidays, training program, amongst others, for MSEs. It was also recommended for funding agencies to consider the trends of practicing MSEs towards addressing critical economic and social issues such as job creation, in granting them funding facilities, in order to facilitate continuous participation in job creation among Nigerian MSEs.
AcknowledgmentThe authors appreciate the Management of Covenant University for funding the publishing of this manuscript in this journal.
MAHDIISME DALAM HADIS-HADIS MAHDAWIYAH
Authors: Muqtada Muhammad Rikza
Published: May 2020

This paper discusses the origins of Mahdiism (al-Mahdi al-Muntaẓar) that are constructed using the mahdawiyyah ḥadīth with the status of aḥad (single transmitter) and ḍa'īf (weak). Nevertheless, this belief (Mahdiism) has deep roots in the theological reason of Muslims. By the historical approach, the finding shows that Mahdiism has roots in millenarianism (belief of the saviors' presence) that had existed in pre-Islamic traditions, such as Jewish and Christian. The elementary form of Islamic millenarianism is the concept of prophethood, but when the prophethood concept was deemed finished, it continued into the concept of Mahdiism. The first emergence of Mahdiism is in line with the emergence of mahdawiyyah ḥadīth. The emergence context of the mahda­wiyyah ḥadīth revolves around the power transition from the Umayyad dynasty to the Abbasid dynasty, which always involved Shiite followers as the political victims. The contact between Shiites with the Jewish former and Christian former during the conflict at that time influenced the style of Shiite theology, like as millenarianism. The Shi'ites propagate the presence of al-Mahdi, as the savior from descendants of the prophet (Ahl al-Bait) described through the mahdawiyyah hadiths. Among the narrators of mahdawiyyah ḥadīth are Jewish former (Ka'ab al-Aḥbar) and Christians former (Wahb b. Munabbih). They were the pioneers who incorporated the millenarianism into the Mahdiism.
REBO WEKASAN MENURUT PERSPEKTIF KH. ABDUL HAMID DALAM KANZ AL-NAJĀḤ WA AL-SURŪR
Authors: Farida Umma
Published: May 2020

This article aims to describe Rebo Wekasan and its various rituals by focusing on the thoughts of KH. Abdul Hamid Kudus have written particularly in his work Kanz al-Najāḥ wa al-Surūr. The data was collected through the documen­tation method and analyzed critically. This study found that Rebo Wekasan ritual is local wisdom combined with Islamic values. The origins of rituals carried out by some Indonesian Muslim people, especially on Java, often refer to the opinion of KH. Abdul Hamid Kudus. His thought is that Allah reveals various kinds of disasters and trials on the last Wednesday of the month of Ṣafar, so that people were advised to perform certain rituals such as sunnah prayers, reading verses of the Qur'an, ṣalawat, and praying. These rituals are indeed practiced in several areas in Java with various modifications of local traditions which are manifested in the form of cultural carnivals, Quranic recitations, and selamatan (local gathering). However, his book is an inseparable from criticism, especially criticisms of sources that are considered less authoritative and critical in terms of the quality of the hadith about Rebo Wekasan.
Applicability of urban streets as temporary open floodways
Authors: Skrede Thea Ingeborg , Muthanna Tone Merete , Alfredesen Knut
Published: May 2020

Climate change coupled with urbanization and its increasing impervious surfaces have caused major challenges for the water sector worldwide. In Norway, an ageing infrastructure with already insufficient drainage capacities results in large amounts of runoff during high-intensity rainfall events causing frequent floods in urban areas. Due to limited available space to handle the future projected increase in stormwater, there is a need to utilize already occupied space for stormwater management, such as roads and streets, during extreme events. Limited research has been done on the design and applicability of urban streets as temporarily flood ways diverting stormwater to the nearest recipient. This paper will study the benefits and limitations of adapting urban streets as safe flood ways to route stormwater by modelling an urban street as a floodway. Streets as floodways will require additional hydraulic performance criteria and safety criteria. Performance criteria are identified and evaluated, and a method is proposed for the evaluation of urban streets applicability as floodways. The method can be used to evaluate the applicability of multifunctional streets used as urban floodways and can be adapted by municipalities as a decision support tool for stormwater management.
Solar energy-based water treatment system applicable to the remote areas: Case of Indonesia
Authors: Wibowo Arsanto Ishadi , Chang Keh-Chin
Published: May 2020

Remote areas usually lack basic clean water services. Considering low population, poor geographical accessibility and lack of electricity, a small-scaled water treatment system capable of producing clean fresh water associated with solar thermal/photovoltaic applications, which is characterized with low capital cost, easy operation and less need of maintenance, is employed in the techno-economic study. Indonesia is one of the countries which owns considerable water resources in their territories but has moderate coverage in basic water services, and is chosen as a case for demonstration. The price of clean water from this system is profitable as compared to that of bottled water, which is an accessible safe water in these areas, but still much higher than that of municipal water.

This article has been made Open Access thanks to the generous support of a global network of libraries as part of the Knowledge Unlatched Select initiative.
A comparative study on rainfall runoff control indicators of green roof
Authors: Zhou Ke
Published: May 2020

The rainfall runoff reduction effect on green roofs was analyzed and tested by comparative rainfall runoff monitoring on impermeable roofs (sloping, plane). The evaluation index of rainfall runoff interception benefit (relative runoff reduction rate, rainfall control rate) on green roofs was studied. The results show that compared with sloping and level roofs, the change range of green roof runoff reduction rate relative to level and sloping roofs is 20.0–98.3% and 3.8–92.3%, and the mean value is 48.4% and 34.3% respectively. It is obvious that the green roof has better rainfall runoff reduction effect. It can be seen from the single rainfall control effect that the variation range of green roof rainfall runoff control rate is 36.0% to 99.0%, and the total rainfall control rate is 57.6%, which reflects that the green roof has the better rainfall control effect. Through comparative study, it can be concluded that the rainfall runoff control rate is more suitable for the design index of green roofs.
Świątynia pod wezwaniem Zesłania Ducha Świętego w Otwocku, jej wystrój, symbolika i treści teologiczne dekoracji
Authors: Kobielus Stanisław
Published: May 2020

W powstaniu struktury architektonicznej budowli świątyni pod wezwaniem Zesłania Ducha Świętego w Otwocku miał udział zespół architektów. Udział w dyskusji nad programem dekoracji wzięli: ks. Stanisław Kobielus, ks. Henryk Herkt oraz artysta Andrzej Zaborowski. Budowę świątyni ukończono w 1987 r. zaś konsekracji dokonał 7 maja 1988 r. ks. biskup Marian Duś. Świątynia posiada bardzo bogaty program ideowy związany z symboliką figur geometrycznych i odwołujący się do tekstów Pisma Świętego, Ojców Kościoła, a także Katechizmu Kościoła Katolickiego. Na ścianie ołtarzowej przedstawiono scenę Zesłania Ducha Świętego, ponieważ parafia i świątynia noszą takie wezwanie. Jednak ideą przewodnią w dekoracji kościoła jest tematyka Niebiańskiej Jerozolimy, która do dziś w Kościele jest uznawana za alegoryczne miejsce ostatecznego szczęścia człowieka po śmierci.

The Pentecost church in Otwock. Symbolism and theological meaning of its decoration

A group of architects worked on the form of the building of the Pentecost church in Otwock. Rev. Stanisław Kobielus, Rev. Henryk Herkt and artist Andrzej Zaborowski discussed the decoration and detailing. The building was finished in 1987 and it was consecrated on the 7th May 1988 by Bishop Marian Duś. The complex ideological decoration of the church is related to the symbolism of geometric figures and refers back to the Scriptures, the writings of the Fathers of the Church and the Catechism of the Catholic Church. The altar centrepiece presents the Pentecost scene referring to the invocation of the church and its parish. However, the main theme in the decoration of the church is the representation of the New Jerusalem which until today is considered by the Church as an allegorical place of eternal happiness after death.
Proteomics of Pancreatic Neuroendocrine Tumors: A Systematic Review
Authors: Maiorano Brigida Anna , Schinzari Giovanni , Chiloiro Sabrina , Visconti Felicia , Milardi Domenico , Bianchi Antonio
Published: May 2020

Pancreatic neuroendocrine tumors (PanNETs) are rare tumors having usually an indolent
behavior, but sometimes with unpredictable aggressiveness. PanNETs are more often
non-functioning (NF), unable to produce functioning hormones, while 10-30% present as functioning
(F) - PanNETs, such as insulinomas , gastrinomas , and other rare tumors. Diagnostic
and prognostic markers, but also new therapeutic targets, are still lacking. Proteomics techniques
represent therefore promising approaches for the future management of PanNETs. We conducted a
systematic review to summarize the state of the art of proteomics in PanNETs. A total of 9 studies
were included, focusing both on NF- and F-PanNETs. Indeed, proteomics is useful for the diagnosis,
the prognosis and the detection of therapeutic targets. However, further studies are required. It
is also warranted to standardize the analysis methods and the collection techniques, in order
to validate proteins with a relevance in the personalized approach to PanNETs management.
Rosetta and the Journey to Predict Proteins’ Structures, 20 Years on
Authors: Abbass Jad , Nebel Jean-Christophe
Published: May 2020

For two decades, Rosetta has consistently been at the forefront of protein structure
prediction. While it has become a very large package comprising programs, scripts, and tools, for
different types of macromolecular modelling such as ligand docking, protein-protein docking,
protein design, and loop modelling, it started as the implementation of an algorithm for ab initio
protein structure prediction. The term ’Rosetta’ appeared for the first time twenty years ago in the
literature to describe that algorithm and its contribution to the third edition of the community wide
Critical Assessment of techniques for protein Structure Prediction (CASP3). Similar to the Rosetta
stone that allowed deciphering the ancient Egyptian civilisation, David Baker and his co-workers
have been contributing to deciphering ’the second half of the genetic code’. Although the focus of
Baker’s team has expended to de novo protein design in the past few years, Rosetta’s ‘fame’ is
associated with its fragment-assembly protein structure prediction approach. Following a
presentation of the main concepts underpinning its foundation, especially sequence-structure
correlation and usage of fragments, we review the main stages of its developments and highlight
the milestones it has achieved in terms of protein structure prediction, particularly in CASP.
Anticancer Properties of Asian Water Monitor Lizard (Varanus salvator), Python (Malayopython reticulatus) and Tortoise (Cuora kamaroma amboinensis)
Authors: Jeyamogan Shareni , Khan Naveed A. , Sagathevan Kuppusamy , Siddiqui Ruqaiyyah
Published: May 2020

Background:

Cancer contributes to significant morbidity and mortality despite advances in treatment and supportive care. There is a need for the identification of effective anticancer agents. Reptiles such as tortoise, python, and water monitor lizards are exposed to heavy metals, tolerate high levels of radiation, feed on rotten/germ-infested feed, thrive in unsanitary habitat and yet have prolonged lifespans. Such species are rarely reported to develop cancer, suggesting the presence of anticancer molecules/mechanisms.

Methods:

Here, we tested effects from sera of Asian water monitor lizard (Varanus salvator), python (Malayopython reticulatus) and tortoise (Cuora kamaroma amboinensis) against cancer cells. Sera were collected and cytotoxicity assays were performed using prostate cancer cells (PC3), Henrietta Lacks cervical adenocarcinoma cells (HeLa) and human breast adenocarcinoma cells (MCF7), as well as human keratinized skin cells (Hacat), by measuring lactate dehydrogenase release as an indicator for cell death. Growth inhibition assays were performed to determine the effects on cancer cell proliferation. Liquid chromatography mass spectrometry was performed for molecular identification.

Results:

The findings revealed that reptilian sera, but not bovine serum, abolished viability of Hela, PC3 and MCF7 cells. Samples were subjected to liquid chromatography mass spectrometry, which detected 57 molecules from V. salvator, 81 molecules from Malayopython reticulatus and 33 molecules from C. kamaroma amboinensis and putatively identified 9 molecules from V. salvator, 20 molecules from Malayopython reticulatus and 9 molecules from C. kamaroma amboinensis when matched against METLIN database. Based on peptide amino acid composition, binary profile, dipeptide composition and pseudo-amino acid composition, 123 potential Anticancer Peptides (ACPs) were identified from 883 peptides from V. salvator, 306 potential ACPs from 1074 peptides from Malayopython reticulatus and 235 potential ACPs from 885 peptides from C. kamaroma amboinensis.

Conclusion:

To our knowledge, for the first time, we reported comprehensive analyses of selected reptiles’ sera using liquid chromatography mass spectrometry, leading to the identification of potentially novel anticancer agents. We hope that the discovery of molecules from these animals will pave the way for the rational development of new anticancer agents.
De wereld is zozeer van de levenden en zo weinig van de doden
Authors: Verdoodt Frans-Jos
Published: May 2020

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Recensie van: Emile Verhaeren. Vlaams dichter voor Europa / Paul Servaes
Authors: Hemmerijckx Rik
Published: May 2020

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Recensie van: De plicht van de dichter. Hugo Claus en de politiek / Kevin Absillis, Sarah Beeks, Kris Lembrechts & Georges Wildemeersch (red.)
Authors: Van Campenhout Nico
Published: May 2020

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Signalement van: Hendrik Conscience. Van geboorte tot leeuw, 1812-1838 / Karel Wauters
Authors: Van Eenoo Romain
Published: May 2020

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WT 75 vijfenzeventig jaar jong
Authors: De Wever Bruno
Published: May 2020

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Radicalisering van Pol De Mont tot de Belgische Werkliedenpartij
Authors: De Wever Bruno
Published: May 2020

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De hete zomer van 1917
Authors: De Wever Bruno
Published: May 2020

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Roma locuta, causa finita?
Authors: Verdoodt Frans-Jos
Published: May 2020

De Heilige Stoel, d.w.z. het hoogste bestuurslichaam van de Rooms-Katholieke Kerk, toonde tijdens de Eerste Wereldoorlog in ruime mate begrip voor de verzuchtingen van de Vlaamse beweging. In de ogen van ‘Rome’ waren die verzuchtingen terecht: op grond van hun miskenning in het verleden, verdienden de Vlamingen, na de afloop van de oorlog, een tegemoetkomende houding vanwege de burgerlijke en kerkelijke overheid. Dat de katholieke aartsbisschop Désiré Mercier (1851-1926) die tegemoetkoming radicaal bleef afwijzen, stuitte in Rome nauwelijks op begrip. En dat de kardinaal-aartsbisschop zich daarenboven steeds meer profileerde als het symbool van het verzet tegen de Duitse bezetter versterkte het ongenoegen bij sommige leden van de Romeinse Curie.De Heilige Stoel mocht dan wel oordelen dat de Vlaamse Kwestie na de oorlog moest worden beslecht, zolang die oorlog woedde, wenste men een pragmatisch standpunt in te nemen: de bezetting was beslist een kwaad, maar daarom diende men nog niet op te roepen tot een burgeroorlog.__________

Roma locuta, causa finita?

The Holy See, that is to say, the highest administrative body of the Roman Catholic Church, demonstrated a broad understanding for the aspirations of the Flemish Movement during the First World War. In the eyes of ‘Rome’ these aspirations were just: on account of the poor treatment that they had received in the past, the Flemings deserved an accommodating attitude from the civil and ecclesiastical authorities after the end of the war. The fact that Catholic archbishop Désiré Mercier (1851-1926) remained radically opposed to this accommodation was met with bewilderment in Rome. What’s more, the fact that the Cardinal-Archbishop also began to present himself more and more as the symbol of resistance to the German occupier strengthened the displeasure among some members of the Roman Curia.The Holy See could certainly proclaim that the Flemish Question needed to be settled after the war; so long as the war raged they wanted to take a pragmatic point of view: the occupation was certainly wicked, but still, one did not have to call for a civil war on its account.
Het Willemsfonds in Lokeren na de Tweede Wereldoorlog: een atypisch verhaal
Authors: Baetens Jacqueline , Van Campenhout Nico
Published: May 2020

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Signalement van: De Franse Nederlanden, Jaarboeken 42, 41 en 40
Authors: Verdoodt Frans-Jos
Published: May 2020

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Численные исследования особенностей обтекания крыла в режиме бафтинга
Authors: Воеводин А.В. , Петров Д.А. , Петров А.С. , Судаков В.Г. , Судаков Г.Г.
Published: May 2020

The numerical method validation using the Reynolds equations and calculations were made for the case of infinite aspect ratio rectangular wing, which is streamed by a transonic unbounded air flow in buffet regime. It is shown, that instead of 2D flow, a periodical flow along the lateral direction is realized. Furthermore, the oscillations in time along the longitudinal direction (buffet) take place. The presence of the side wind tunnel walls deforms this periodical structure and changes the buffet frequency. Calculations of the wing-body combination flow show that the oscillations take place inside the restricted wing area both along longitudinal and lateral directions.
Многопользовательский доступ в системах относительной передачи информации на основе хаотических радиоимпульсов
Authors: Дмитриев А.С. , Мохсени Т.И. , Сьерра-Теран К.М.
Published: May 2020

Abstract The possibility of organizing multiuser access based on the differentially coherent information transmission scheme using chaotic radio pulses as data carriers has been demonstrated. Some theoretical estimates were made for the maximum number of subscribers and the information capacity of a multiuser system. Computer-aided modeling was performed to validate the obtained theoretical results.
Металлопористые катоды, модифицированные наноуглеродом, с высокой долговечностью для применения в приборах СВЧ
Authors: Крачковская Т.М. , Мельников Л.А. , Глухова О.Е. , Шунаев В.В. , Шалаев П.Д.
Published: May 2020

The results of calculations of the physical and energy parameters of nanocarbon structures with components of the active substance of the dispenser cathode, which are in good agreement with experience, are presented. It was experimentally determined that the active substance modified by the sulfoadduct of carbon nanoclusters has an evaporation rate of 1.5 times lower than the typical one. Tests of cathodes modified by nanocarbon as part of space-based TWTs showed a durability of 1740800 hours with a current density of 0.645 A / cm2.
Enhanced Enrollment in the National Diabetes Prevention Program to Increase Engagement and Weight Loss for the Underserved: Protocol for a Randomized Controlled Trial
Authors: Ritchie Natalie D , Holtrop Jodi Summers , Gritz R Mark , Sauder Katherine Ann , Durfee Michael Josh , Dickinson L Miriam , Kaufmann Peter G
Published: May 2020

Background

Type 2 diabetes affects 9.4% of US adults with higher rates among racial and ethnic minorities and individuals of low socioeconomic status. The National Diabetes Prevention Program (NDPP) is an evidence-based and widely disseminated behavioral intervention to reduce diabetes incidence through modest weight loss. However, retention in the yearlong NDPP is problematic and leads to suboptimal weight loss, especially among diverse, underserved populations. Strategies to improve NDPP engagement and weight loss are needed urgently. Pilot results of the pre-NDPP, a novel enhancement to enrollment in the NDPP based on the Health Belief Model, were highly successful in a nonrandomized cohort study among 1140 racially diverse, predominately low-income participants. A total of 75 presession participants had doubled attendance and weight loss as compared with earlier participants who did not receive presessions. On the basis of these promising results, we are conducting a randomized controlled trial (RCT) to determine whether pre-NDPP reliably improves NDPP outcomes, as reported on ClinicalTrials.gov.

Objective

This study aims to (1) conduct an RCT comparing NDPP attendance and weight loss outcomes between participants who receive pre-NDPP versus direct enrollment into the NDPP (usual care), (2) examine potential effect mediators (perceived risk for developing diabetes and self-efficacy and readiness for weight control) and moderators (race and ethnicity; income level), and (3) evaluate implementation factors, including cost and projected return on investment.

Methods

This two-arm RCT will compare outcomes among diverse, predominately low-income participants who receive pre-NDPP versus direct enrollment into the NDPP (usual care). This is a type 1 hybrid effectiveness-implementation design to determine clinical effectiveness through an RCT, while assessing factors that may impact future pre-NDPP dissemination and implementation, including cost. Our primary research question is whether pre-NDPP improves NDPP attendance and weight loss compared with standard NDPP delivery.

Results

This project was funded in April 2019. Recruitment is underway as of July 2019. Initial participants began the intervention in October 2019. Data analysis and results reporting are expected to be completed in 2024.

Conclusions

This RCT of pre-NDPP may lead to future dissemination of a scalable, evidence-based strategy to improve success of the NDPP, reduce disparities in NDPP effectiveness, and help prevent type 2 diabetes across the country.

Trial Registration

ClinicalTrials.gov NCT04022499; https://clinicaltrials.gov/ct2/show/NCT04022499.

International Registered Report Identifier (IRRID)

PRR1-10.2196/15499
Investigating the Efficacy and Cost-Effectiveness of Technology-Delivered Personalized Feedback on Dietary Patterns in Young Australian Adults in the Advice, Ideas, and Motivation for My Eating (Aim4Me) Study: Protocol for a Randomized Controlled Trial
Authors: Haslam Rebecca L , Pezdirc Kristine , Truby Helen , Attia John , Hutchesson Melinda , Burrows Tracy , Callister Robin , Hides Leanne , Bonevski Billie , Kerr Deborah A , Lubans David , Kirkpatrick Sharon , Rollo Megan , McCaffrey Tracy , Collins Clare E
Published: May 2020

Background

Web-based health interventions may be easier to access and time efficient relative to face-to-face interventions and therefore may be the most appropriate mode to engage young adults.

Objective

This study aims to investigate the impact of 3 different levels of personalized web-based dietary feedback and support on changes in diet quality.

Methods

The Advice, Ideas, and Motivation for My Eating (Aim4Me) study is a 12-month assessor-blinded, parallel-group randomized controlled trial evaluating the impact of 3 levels of web-based feedback on diet quality, measured using the Australian Recommended Food Score (ARFS). Participants (N=2570) will primarily be recruited via web-based methods and randomized to 1 of 3 groups. Group 1 (control) will receive the Healthy Eating Quiz, a web-based dietary assessment tool that generates a brief feedback report on diet quality. Individuals randomized to this group can use the brief feedback report to make positive dietary changes. Group 2 will receive the Australian Eating Survey, a web-based dietary assessment tool that generates a comprehensive feedback report on diet quality as well as macro- and micronutrient intake. Group 2 will use the comprehensive feedback report to assist in making positive dietary changes. They will also have access to the Aim4Me website with resources on healthy eating and tools to set goals and self-monitor progress. Group 3 will receive the same intervention as Group 2 (ie, the comprehensive feedback report) in addition to a tailored 30-min video consultation with an accredited practicing dietitian who will use the comprehensive feedback report to assist individuals in making positive dietary changes. The self-determination theory was used as the framework for selecting appropriate website features, including goal setting and self-monitoring. The primary outcome measure is change in diet quality. The completion of questionnaires at baseline and 3, 6, and 12 months will be incentivized with a monetary prize draw.

Results

As of December 2019, 1277 participants have been randomized.

Conclusions

The web-based delivery of nutrition interventions has the potential to improve dietary intake of young adults. However, the level of support required to improve intake is unknown.

Trial Registration

Australian New Zealand Clinical Trials Registry ACTRN12618000325202; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374420

International Registered Report Identifier (IRRID)

DERR1-10.2196/15999
Patient-Reported Outcomes in a Nationally Representative Sample of Older Internet Users: Cross-sectional Survey
Authors: Seckin Gul , Hughes Susan
Published: May 2020

Background

The rapid diffusion of the internet has decreased consumer reliance on health care providers for health information and facilitated the patients’ ability to be an agent in control of their own health. However, empirical evidence is limited regarding the effects of health-related internet use among older adults, which is complicated by the proliferation of online health and medical sources of questionable scientific accuracy.

Objective

We explore the effects of health-related internet use, education, and eHealth literacy on medical encounters and patient-reported outcomes. Patient-reported outcomes are categorized into two dimensions: (1) self-reported health problem and (2) affective distress (feeling worried and anxious) due to information obtained. We were particularly interested in whether education and eHealth literacy moderate the association between perceived strain in medical encounters and patient-reported outcomes.

Methods

Our study sample consisted of online panel members who have used the internet as a resource for health information, randomly drawn from one of the largest probability-based online research panels. This paper specifically reports results obtained from older panel members (age≥60 years: n=194). First, we examined descriptive statistics and bivariate associations (Pearson correlations and independent samples t tests). We used hierarchical ordinary least squares regression analyses by running separate regressions for each patient-reported outcome. In model 1, we entered the main effects. In model 2, technology and medical encounter variables were included. Model 3 added the statistical interaction terms.

Results

Age (β=–.17; P=.02), gender (β=–.22; P=.01), and medical satisfaction (β=–.28; P=.01) were significant predictors of self-reported health problems. Affective distress was positively predicted by gender (β=.13; P=.05) and satisfaction with medical encounters (β=.34; P<.001) but negatively predicted by education (β=–.18; P=.03) and eHealth literacy (β=–.32; P=.01). The association between experiencing a health problem in relation to health-related internet use and perception of strained medical encounters was greater among respondents with lower levels of education (β=–.55; P=.04). There was also a significant interaction between education and eHealth literacy in predicting the level of affective distress (β=–.60; P=.05), which indicated that higher levels of education predicted lower averages of feeling anxiety and worry despite lower eHealth literacy. Older women reported higher averages of affective distress (β=.13; P=.05), while older men reported higher averages of experiencing a self-reported health problem (β=–.22; P=.01).

Conclusions

This study provides evidence for the effect of health-related internet use on patient-reported outcomes with implications for medical encounters. The results could be used to guide educational and eHealth literacy interventions for older individuals.
User Experiences of an Internet-Based Stepped-Care Intervention for Individuals With Cancer and Concurrent Symptoms of Anxiety or Depression (the U-CARE AdultCan Trial): Qualitative Study
Authors: Igelström Helena , Hauffman Anna , Alfonsson Sven , Sjöström Jonas , Cajander Åsa , Johansson Birgitta
Published: May 2020

Background

The internet-based stepped-care intervention iCAN-DO, used in the multicenter randomized controlled trial AdultCan, was developed for adult patients undergoing treatment for cancer and concurrently experiencing anxiety or depressive symptoms. iCAN-DO aimed to decrease symptoms of anxiety or depression. Step 1 comprises access to a library with psychoeducational material and a peer-support section, as well as the possibility to pose questions to a nurse. Step 2 of the intervention offers treatment consisting of internet-based cognitive behavioral therapy (iCBT) to participants still experiencing anxiety or depression at 1, 4, or 7 months after inclusion.

Objective

The study aimed to explore user experiences of delivery, design, and structure of iCAN-DO from the perspective of people with cancer.

Methods

We studied user experiences by interviewing 15 informants individually: 10 women with breast cancer (67%), 4 men with prostate cancer (27%), and 1 man with colorectal cancer (7%) with a mean age 58.9 years (SD 8.9). The interviews focused on informants' perceptions of ease of use and of system design and structure. Informants had been included in iCAN-DO for at least 7 months. They were purposefully selected based on activity in Step 1, participation in iCBT (ie, Step 2), gender, and diagnosis.

Results

Of the 15 informants, 6 had been offered iCBT (40%). All informants used the internet on a daily basis, but 2 (13%) described themselves as very inexperienced computer users. The analysis revealed three subthemes, concerning how user experiences were affected by disease-specific factors and side effects (User experience in the context of cancer), technical problems (Technical struggles require patience and troubleshooting), and the structure and design of iCAN-DO (Appealing and usable, but rather simple).

Conclusions

The results indicate that user experiences were affected by informants’ life situations, the technical aspects and the design of iCAN-DO, and informants’ preferences. The results have generated some developments feasible to launch during the ongoing study, but if iCAN-DO is to be used beyond research interest, a greater level of tailoring of information, features, and design may be needed to improve user experiences. The use of recurrent questionnaires during the treatment period may highlight an individual’s health, but also function as a motivator showing improvements over time.
Digital Gamification to Enhance Vaccine Knowledge and Uptake: Scoping Review
Authors: Montagni Ilaria , Mabchour Inass , Tzourio Christophe
Published: May 2020

Background

Vaccine hesitancy is a growing threat to population health, and effective interventions are needed to reduce its frequency. Digital gamification is a promising new approach to tackle this public health issue.

Objective

The purpose of this scoping review was to assess the amount and quality of outcomes in studies evaluating gamified digital tools created to increase vaccine knowledge and uptake.

Methods

We searched for peer-reviewed articles published between July 2009 and August 2019 in PubMed, Google Scholar, Journal of Medical Internet Research, PsycINFO, PsycARTICLES, Psychology and Behavioral Sciences Collection, and SocINDEX. Studies were coded by author, year of publication, country, journal, research design, sample size and characteristics, type of vaccine, theory used, game content, game modality, gamification element(s), data analysis, type of outcomes, and mean quality score. Outcomes were synthesized through the textual narrative synthesis method.

Results

A total of 7 articles met the inclusion criteria and were critically reviewed. Game modalities and gamification elements were diverse, but role play and a reward system were present in all studies. These articles included a mixture of randomized controlled trials, quasi-experimental studies, and studies comprising quantitative and qualitative measures. The majority of the studies were theory-driven. All the identified gamified digital tools were highly appreciated for their usability and were effective in increasing awareness of vaccine benefits and motivation for vaccine uptake.

Conclusions

Despite the relative paucity of studies on this topic, this scoping review suggests that digital gamification has strong potential for increasing vaccination knowledge and, eventually, vaccination coverage.