bluuebunny/crossref_metadata_2025 huggingface dataset:
Early impaired relaxation of the left ventricle in isolated, uncomplicated prehypertension without left ventricular hypertrophy can be detected by exercise electrocardiography
Authors: Mittal S.R.
Published: September 2024

Nearly fifty percent of patients with isolated, uncomplicated prehypertension have impaired relaxation of the left ventricle even in the absences of left ventricular hypertrophy. Such early impairment of the left ventricular relaxation can be detected by exercise electrocardiography. Transient increase, in the area of the negative terminal deflection of the P wave in lead V1 (>0.04mVaec) during and/or early recovery suggested transient increase in the left atrial pressure due to unmasking of the early impairment of the left ventricular relaxation by exercise induced tachycardia.
The Quality of Parent-Child Interaction and Its Impact on Juvenile Delinquency at Kartika X-2 Vocational School in South Jakarta, Indonesia
Authors: Puspita Ratumas Ratih , Farida Nita , Lena Erlena
Published: September 2024

Background: Recent data in the Indonesian Child Protection Commission (KPAI) reported an increase in juvenile delinquency cases in Indonesia over recent years. Interviews conducted in Jakarta revealed that a significant portion of students admitted to behaviors such as being absent from class, sleeping during class time, and participating in school fights. Additionally, many students indicated that they do not seek advice or discuss issues that occur both in and out of school, with their parents when facing problems, while a smaller portion reported the opposite. Objective: The present study aims to determine the relationship between the quality of parent-child interactions in the family and the tendency for juvenile delinquency among students at Kartika X-2 Vocational School in South Jakarta. Methods: This study employed a quantitative, cross-sectional research design. The sample in this study consisted of 92 respondents from classes I and II at Kartika X-2 Vocational School in South Jakarta. The study participants were selected using a non-probability sampling technique with the quota sampling method. Results: The statistical tests using the Pearson's Product Moment test obtained a correlation value of 0.543 with a significant value of 0.000 < 0.05. This shows that there is a significant relationship between the correlation results of parent-child interactions in the family and the tendency for juvenile delinquency. Conclusion: There is a relationship between the quality of parents and children in the family and the tendency for juvenile delinquency among students. Nurses should develop more strategies for providing parental education, as parental control and supervision are crucial factors in raising children effectively.
A rare case of central nervous system pancreatoblastoma metastasis: illustrative case
Authors: Mastropasqua Vincenzo , Obersnel Marco , Stifano Vito , Gessi Marco , Cristiano Corsi Domenico , Doglietto Francesco
Published: September 2024

BACKGROUND

Pancreatoblastoma is a malignant neoplasm of the pancreas, occurring usually in children and rarely in adults. Treatment consists of surgery with a variable combination of adjuvant therapies. Liver metastases are common, whereas brain diffusion is exceptionally rare.

OBSERVATIONS

The authors report the case of a 42-year-old man with a 16-year history of metastatic pancreatoblastoma, previously treated with surgery, chemotherapy, and radiotherapy, demonstrating a partial response. He presented with headache and dizziness, and brain magnetic resonance imaging (MRI) showed a cerebellar lesion. A craniotomy was performed with complete tumor removal, and the postoperative course was uneventful. Brain MRI showed gross-total resection of the lesion, and the patient was discharged with an improvement of the preoperative symptoms. Histopathological analysis confirmed the diagnosis of metastasis from pancreatoblastoma. The patient received adjuvant stereotactic radiotherapy and showed further clinical improvement at the last follow-up.

LESSONS

Brain metastases from pancreatoblastoma are exceptionally rare and poorly described in the literature. There is no standard therapy for this condition; hence, patients usually undergo treatments similar to those for other central nervous system metastases. All the described patients have had good clinical outcomes yet short-term follow-ups; therefore, further investigations are needed to better understand the best treatments for this condition.

https://thejns.org/doi/10.3171/CASE23764
Ventral epidural stimulation for motor recovery after spinal cord injury: illustrative case
Authors: Afridi Abdullah K , Steele Alexander G , Martin Catherine , Sayenko Dimitry G , Barber Sean M
Published: September 2024

BACKGROUND

Spinal cord stimulation (SCS) has demonstrated potential as a therapy to enhance motor functional recovery after spinal cord injury (SCI). Epidural SCS for motor recovery is traditionally performed via the dorsal electrode. While ventral epidural stimulation may provide more direct and specific stimulation of the ventral motor neurons involved in motor control, it is largely unstudied, and its role in motor recovery after SCI is unclear. In order to profile the safety and feasibility of ventral epidural spinal stimulation (VSS), the authors present a patient who underwent VSS following a corpectomy to treat SCI related to metastatic epidural cord compression.

OBSERVATIONS

A patient underwent transpedicular corpectomy for spinal cord decompression, as well as the placement of 2 ventral epidural electrodes, followed by concurrent physical therapy and ventral epidural stimulation. He was nonambulatory preoperatively but was able to walk over 300 feet with the assistance of a rolling walker at the conclusion of the 3-week study period. VSS was noted to produce improvements in muscle contraction when stimulation was on.

LESSONS

VSS appears to be safe, feasible, and well tolerated. VSS, as compared to standard-of-care therapy for SCI, can be used in conjunction with physical therapy and may lead to improvements in motor function.

https://thejns.org/doi/10.3171/CASE24155
Bibliografia naukowa o. prof. dr. hab. Henryka Pietrasa SJ
Authors: Wysocki Marcin
Published: September 2024

Bibliografia naukowa o. prof. dr. hab. Henryka Pietrasa SJ
Stone-cast matrix based on alloy of basalt and metal oxides. Part II. Basalt–ZrO2 system
Authors: Martynov K. V. , Kulemin V. V. , Krasavina E. P. , Rumer I. A. , Kostikova G. V. , Kulyukhin S. A.
Published: September 2024

Phase formation in stone-cast matrices (SCMs) obtained as a result of the interaction of molten basalt with ZrO2at 1623 K for 5 h on air was studied. Basalt melted under the above conditions contains two spinels (relict and newly formed), clinopyroxene of the composition Mg0.66Ca0.60Fe0.26Ti0.05Al0.66Si1.80O6, and glass as the main phases. When basalt is fused with ZrO2, taken in a mass ratio of 1 : 1, SCMs containing zircon (ZrSiO4), glass, and baddeleyite (ZrO2) as the main phases are formed. Zirconium is concentrated mainly in two phases, zircon and baddeleyite. The rate of Zr leaching from the synthesized SCMs into H2O after 28 days is ~1.0 × 10–9g/(cm2day).
Analysis of the Possibilities of Energy Supply to Consumers in Cold Conditions During Large-Scale Emergency Installations in the Gas Industry
Authors: Senderov S. M. , Beresneva N. M.
Published: September 2024

The article presents the main components of the methodological approach to the analysis of the possibilities of supplying final types of energy to consumers in the event of a loss of performance of critical facilities of the Russian gas industry in conditions of cooling in the territories of the federal districts. The principle of choosing a territorial section for analyzing the situation with a simultaneous increase in demand for fuel and energy resources is described. An algorithm for conducting research is given. Research is carried out by modeling the work of the country’s fuel and energy complex during the period of the average day of January in the conditions of a peak-increasing demand for thermal energy in the territories of federal districts. At the same time, the cooling is modeled in turn for each of the federal districts in the zone of operation of the Unified Gas Supply System of Russia. An analysis of the possibilities of meeting the demand for final types of energy in the constituent entities of the Russian Federation is carried out for all key scenarios of cooling and loss of efficiency of critical gas industry facilities. The principles of modeling the situation with the supply of final types of energy to consumers in these situations are shown. The most vulnerable regions under the analyzed conditions are identified. The conclusion is made about the need for a balanced approach to determining the optimal degree of dominance of natural gas in the fuel and energy balance of the regions, taking into account the existing opportunities for its supply in the conditions of large-scale emergencies in the gas industry.
Датчик энергии пучка электронов, основанный на эффекте Вавилова–Черенкова
Authors: Бобылев Д. А. , Сиомаш М. Д. , Ханкин В. В. , Шведунов В. И.
Published: September 2024

Представлены результаты разработки датчика энергии, предназначенного для контроля энергии выведенного в атмосферу пучка электронов ускорителей прикладного назначения. Принцип действия устройства основан на использовании излучения Вавилова–Черенкова, возникающего при прохождении пучка электронов через газ.
Разработка многоканального радиометра на основе кремниевых детекторов для измерения альфа-, бета- и гамма-излучений естественных изотопов
Authors: Раджапов С. А. , Нурбоев К. М. , Муллагалиева Ф. Г. , Раджапов Б. С. , Зуфаров М. А.
Published: September 2024

Приведены результаты разработки универсального радиометрического устройства для измерения активностей альфа-, бета-, гамма-излучений и объемной активности радона в почве, воздухе и воде. Представлены структура многоканального радиометрического устройства с программным обеспечением, схема микроконтроллерного узла с формирователем сигналов, работа электронных узлов. Приводятся данные мониторинга объемной активности альфа-частиц радона и активностей бета- и гамма-излучений в почвенном воздухе. Результаты мониторинга показали зависимость активностей от температуры, влажности и времени суток. Устройство компактное, мобильное, универсальное, может использоваться как стационарно, так и в полевых условиях. Разработанная программа RMI V1.7 позволяет проводить длительный мониторинг в режиме реального времени, все измерения отображаются на мониторе компьютера.
Теплопроницаемость экранно-вакуумной теплоизоляции в атмосфере Марса
Authors: Семена Н. П. , Доброленский Ю. С. , Сербинов Д. В. , Вязоветский Н. А. , Мартынович Ф. Г.
Published: September 2024

Представлены результаты эксперимента по измерению теплопроницаемости типовой экранно-вакуумной теплоизоляции в вакууме и в условиях, имитирующих марсианскую атмосферу. Измерения показали, что данная теплопроницаемость увеличивается приблизительно на одну треть при перемещении экранно-вакуумной теплоизоляции из вакуума в марсианскую атмосферу. Полученные результаты дают возможность корректно определить мощность нагрева покрытых экранно-вакуумной теплоизоляцией приборов на поверхности Марса и тем самым использовать типовую экранно-вакуумную теплоизоляцию для этих приборов и на этапе перелета, и при работе на поверхности Марса. Объектом исследования являлся покрытый экранно-вакуумной теплоизоляцией прибор ИСЕМ, который входил в состав научной аппаратуры несостоявшейся миссии “ЭкзоМарс-2022”.
Respiratory sinus arrhythmia: physiological mechanisms and relationship with systemic blood pressure fluctuations
Authors: Vinogradova O. L. , Borovik A. S. , Zhedyaev R. Yu. , Tarasova О. S.
Published: September 2024

Respiratory sinus arrhythmia (RSA) reflects the functioning of the nervous heart control, predominantly of a parasympathetic nature. The study of RSA mechanisms helps to reveal the physiological patterns of regulation of cardiac activity, and the development of new approaches to its assessment is an urgent medical task. This review will examine experimental approaches that have contributed to the development of modern ideas about autonomic nervous system role in the formation of RSA, as well as the connection between RSA and frequency-matched fluctuations in systemic blood pressure. In addition, we will consider new data on the phase relationships of fluctuations in heart rate and blood pressure in the frequency range of respiratory waves, obtained using wavelet analysis of these physiological signals.
Microbiota-associated diseases as an endotoxin-initiated pathology or intestinal factor in the induction of systemic inflammation and progression of aging
Authors: Morozov S. G. , Sozinov A. S. , Iakovlev M. Yu.
Published: September 2024

The intestinal microbiota is a vital organ – a participant in the processes of adaptation and evolution, an inducer of inflammation and the progression of aging. The key element of the interaction of intestinal microbiota with the body is lipopolysaccharides, the level of which in the general bloodstream increases significantly in so-called “microbiota-associated diseases”, which indicates the participation of endotoxin aggression in their pathogenesis, and most likely their initiation. One of the most common reasons for the development of endotoxin aggression may be quantitative and qualitative changes in the structure of the intestinal microbiota, leading to an increase in intestinal permeability, which are largely determined by nutritional factors. The antiendotoxin component in the treatment regimen for patients with various nosological forms of the diseases significantly increases the effectiveness of the treatment and prophylactic process, which can become one of the most promising areas of anti-aging measures.
Speleoclimatoterapy: psychophysiological mechanisms of influence on the organism of a healthy person
Authors: Dorokhov E. V. , Semiletova V. A.
Published: September 2024

The article considers some psychophysiological mechanisms of the impact of speleoclimate on the human body. The mechanisms of increasing the reserves of the human neuroimmunoendocrine system as a result of a 10-day course of speleotherapy were revealed. Under the influence of speleoclimate, the content of T-lymphocytes, T-helpers, T-cytotoxic lymphocytes increased, an increase in early and late activation of T-lymphocytes and T-regulatory cells, an increase in the number of B-cells and NK cells with the CD3-CD16-CD56+ phenotype; the frequency of occurrence of epithelial cells of the oral cavity with nuclear aberrations decreased. It is noted that the influence of the speleoclimate on the human body is mainly limited by intrasystemic influences, affecting the regulatory system at the level of vagosympathetic interaction. It was revealed that the course of speleotherapy improves the speed of the visual signal, the speed of primary processing of information and the speed of analysis of visual information in terms of the parameters of the sEP. The mechanisms of influence of speleotherapy on the neuroimmunoendocrine system are determined by the initial psychophysiological state of a person. Under the influence of speleotherapy, the vegetative status is restored.
ПРО АСИМПТОТИЧНЕ ІНТЕГРУВАННЯ ЛІНІЙНИХ СИСТЕМ ДИФЕРЕНЦІАЛЬНИХ РІВНЯНЬ З ВІДХИЛЕННЯМ АРГУМЕНТУ
Authors: Самусенко Петро , Даниліна Галина , Рашевський Микола
Published: September 2024

Побудовано асимптотичне зображення розв'язку для основної початкової задачі системи лінійних сингулярно збурених диференціально-різницевих рівнянь. Інтегрування таких систем рівнянь із нестабільним спектром розпочато у працях М. І. Шкіля та його учнів. У цьому дослідженні побудовано асимптотичне зображення розв’язку системи диференціально-різницевих рівнянь із нестабільностями у спектрі головної матриці. Досліджено також нестабільність, характерна лише для рівнянь з відхиленням аргументу. Дано асимптотичні оцінки похибки.
ПРО МЕТРИЧНІ СПІВВІДНОШЕННЯ В ПРЯМОКУТНОМУ ТЕТРАЕДРІ ТА СУМІЖНІ ПИТАННЯ
Authors: Кадубовський Олександр , Бондар Діана
Published: September 2024

Представлена стаття присвячена систематизації фактів геометрії тетраедра, зокрема ортоцентричного і прямокутного та популяризації властивостей прямокутного тетраедра. Також висвітлено авторський підхід до можливого впровадження у шкільний курс геометрії властивостей та метричних співвідношень прямокутного тетраедра шляхом поміркованого добору дидактичного матеріалу під час вивчення відповідних тем стереометрії.
ФОРМУВАННЯ МАТЕМАТИЧНОЇ КОМПЕТЕНТНОСТІ УЧНІВ В ПРОЦЕСІ ВИВЧЕННЯ ТЕМИ «ПОХІДНА ТА ЇЇ ЗАСТОСУВАННЯ»
Authors: Величко Владислав , Сенчук Інна
Published: September 2024

У статті розглядається процес формування математичної компетентності учнів під час вивчення теми «Похідна та її застосування». Зосереджено увагу на інтеграції теоретичних знань і практичних задач, що дозволяє учням усвідомити реальне значення похідної в різних галузях науки та повсякденному житті. Використання практичної направленості курсу математики, сучасних технологій, інтерактивних методів навчання та міждисциплінарних підходів розкриває нові можливості для зацікавлення учнів та підвищення їхньої мотивації до навчання. Стаття акцентує на важливості застосування реальних задач, проектної діяльності для формування ключових навичок і критичного мислення. У висновку підкреслюється необхідність комплексного підходу до навчання, що включає теоретичну підготовку, практичні заняття та використання інноваційних методик, для досягнення високого рівня математичної компетентності учнів.
МЕТОДИ РОЗВ'ЯЗУВАННЯ АСТРОФІЗИЧНИХ ЗАДАЧ У ШКІЛЬНОМУ КУРСІ ФІЗИКИ
Authors: Панчук Анастасія , Бєлошапка Олександр
Published: September 2024

У статті розглядаються різні підходи до викладання астрофізики, їх переваги та недоліки. Використання цих методів сприяє підвищенню якості навчання, розвитку критичного мислення, аналітичних і технічних навичок студентів, а також їх мотивації та інтересу до науки. Це дозволяє вчителям зробити уроки фізики більш наочними та інтерактивними, а також забезпечити індивідуальне навчання, адаптоване до потреб кожного учня.
У роботі також підкреслюється важливість розвитку в учнів умінь правильно формулювати задачі, будувати математичні моделі, виконувати обчислення та аналізувати результати.
Buca Eğitim Fakültesi öğrencilerinin küresel iklim değişikliğine yönelik endişe düzeyleri
Authors: Semenderoğlu Adnan , Sanlı Volkan , Arslan Kürşat
Published: September 2024

İklim, yeryüzünün herhangi bir yerinde uzun yıllar boyunca gözlenen hava koşullarının ortalama durumudur. İklim değişikliği ise genel olarak; iklim koşullarında küresel ve yerel ölçeklerde uzun süreli ve yavaş gelişen anlamlı değişiklikler şeklinde tanımlanabilir. Çalışmanın amacı, Dokuz Eylül Üniversitesi’nde öğrenim görmekte olan öğretmen adaylarının küresel iklim değişikliğine yönelik endişe düzeylerini belirlemektir. Araştırmada nicel araştırma yöntemlerinden kesitsel tarama modeli kullanılmıştır. Çalışmaya kolayda örnekleme yöntemi kullanılarak, Türkçe ve Sosyal Bilimler Eğitimi Bölümü, Bilgisayar ve Öğretim Teknolojileri Eğitimi Bölümü ile Matematik ve Fen Eğitimi Bölümlerinden olmak üzere 11 anabilim dalından toplam 200 öğrenci katılmıştır. Çalışmada Stewart (2021) tarafından hazırlanmış, Gezer & İlhan (2021) tarafından Türkçe’ye uyarlanmış İklim Değişikliği Endişe Ölçeği katılımcılara uygulanmıştır. Verilerin analizinde SPSS Statistics 23 paket programı kullanılmış, tanımlayıcı ve yorumlayıcı istatistikler yoluyla bulgulara ulaşılmıştır. Bulgular, cinsiyet, bölüm, sınıf düzeyi gibi değişkenlerde öğrencilerin iklim değişikliğine yönelik endişe düzeyleri açısından istatistiksel olarak anlamlı farklar ortaya koymazken, yerleşim birimi ve daha önce iklim konusunda ders alma durumu gibi değişkenlere göre anlamlı farklılıklar ortaya koymuştur.
Semantically Describing Predictive Models for Interpretable Insights into Lung Cancer Relapse
Authors: Chudasama Yashrajsinh , Purohit Disha , Rohde Philipp D. , Iglesias Enrique , Torrente Maria , Vidal Maria-Esther
Published: September 2024

Machine learning (ML) is becoming increasingly important in healthcare decision-making, requiring highly interpretable insights from predictive models. Although integrating ML models with knowledge graphs (KGs) holds promise, conveying model outcomes to domain experts remains challenging, hindering usability despite accuracy. We propose semantically describing predictive model insights to overcome communication barriers. Our pipeline predicts lung cancer relapse likelihood, providing oncologists with patient-centric explanations based on input characteristics. Consequently, domain experts gain insights into both the characteristics of classified lung cancer patients and their relevant population. These insights, along with model decisions, are semantically described in natural language to enhance understanding, particularly for interpretable models like LIME and SHAP. Our approach, SemDesLC, documents ML model pipelines into KGs, and fulfills the needs of three types of users: KG builders, analysts, and consumers. Experts’ opinions indicate that semantic descriptions are effective for elucidating relapse determinants. SemDesLC is openly accessible on GitHub, promoting transparency and collaboration in leveraging ML for healthcare decision support.
Access Governance with Linked Data: Authorisation Ontology and Enforcement Mechanisms in the Dutch Federated Data System Context
Authors: Rowland Alexandra , Schevers Hans , Folmer Erwin , Mol Sven , Michielsen Janneke , van Andel Marc
Published: September 2024

To advance the adoption of linked data in the context of the Dutch Federated Data System (Dutch synonym: FDS), it is necessary to have robust access control for native linked data sources. For this purpose, research was initiated to assess whether it is feasible to implement access controls on linked data sources in this context. A four-phase design science research methodology is applied. The first phase defines both the question guiding this research and the context in which the research was conducted. The second phase includes a review of the state-of-the-art and an evaluation of the existing approaches to access control that could support the FDS use case. Having determined that no existing approaches completely fulfil the requirements of the FDS use case, the third phase describes a prototype enforcement mechanism designed and developed as part of this research. The fourth and final phase evaluates this protype with respect to its feasibility to support the requirements of the FDS context. At present, there are no standardized solutions for securing native linked data sources. Existing literature and industry examples from the Netherlands and Europe highlight several potential solution directions for access control on SPARQL endpoints. These solution directions are used as inspiration for the development of a prototype enforcement mechanism. This prototype shows potential when applied to the Dutch Federated Data System and suggests a more generic approach could be taken when applying these controls to a broader context. Further research, testing and standardization efforts are required to bring such an approach to maturity. Any linked data ecosystem containing closed information requires a robust approach to access control. This research contributes to the existing literature on approaches taken to such access controls and highlights the increasing need for, and the feasibility of implementing, these controls in governmental contexts. Bringing such a solution to maturity would support wider adoption of linked data technologies in this context.
Vaginose citolítica: relato de caso
Authors:   USF d’As Terras de Lanhoso, Pereira Bárbara Mendes , Vale Sofia ,   USF d’As Terras de Lanhoso
Published: September 2024

Introdução: A flora vaginal é constituída por diferentes microorganismos que promovem uma interação equilibrada entre o microbioma vaginal, estado hormonal, produtos do metabolismo microbiano e resposta imune do hospedeiro. A instabilidade do ecossistema vaginal pode levar a vulvovaginites, que são um motivo de consulta frequente nos cuidados de saúde primários, sendo a vaginose bacteriana, candidíase vaginal e tricomoníase responsáveis pela maioria dos diagnósticos. Existem outras patologias com apresentações semelhantes que, por serem menos frequentes, não são ponderadas e resultam em diagnósticos e tratamentos errados como a vaginose citolítica. Descrição do caso: Mulher de 20 anos de idade, com queixas de corrimento vaginal abundante, necessidade de uso de penso diário, prurido e alteração de odor com um mês de evolução. Ao exame objetivo destaca-se a ruborização dos lábios externos e introito vaginal, corrimento mucoso abundante, não aderente, não arejado e sem cheiro. É efetuada citologia cervico-vaginal em lâmina, que apresentava inflamação e foi negativa para lesão intraepitelial ou malignidade. Foi pedida cultura de exsudado vaginal, que apresentava abundantes células epiteliais e numerosos bacilos de Doderlein. Tendo em conta o quadro apresentado foi assumido como diagnóstico mais provável vaginose citolítica. Foram dadas recomendações e prescritos banhos de assento com bicarbonato de sódio, tendo a utente ficado assintomática. Comentário: Perante uma doente com sintomas de corrimento vaginal e prurido, a primeira hipótese diagnóstica deverá considerar a prevalência das infeções vulvovaginais mais frequentes. Contudo, a cultura do exsudado permitiu excluir a presença de bactérias, fungos e parasitas. A sintomatologia apresentada pela doente e os achados do exame físico são característicos da vaginose citolítica. A cultura do exsudado corroborou a suspeita, sendo feito o diagnóstico e o tratamento adequados. Com este caso pretende-se alertar os clínicos para a existência desta patologia, que pode muitas vezes passar despercebida, comprometendo a saúde da mulher.
Sífilis secundária com VDRL não reativo: um caso clínico de fenómeno prozona?
Authors:   USF Santa Joana, Ribau Rita , Rua Inês ,   USF Salinas, Martins Elsa ,   USF Santa Joana
Published: September 2024

Introdução: A sífilis é uma doença sexualmente transmissível provocada pela bactéria Treponema pallidum. É uma infeção prevenível e tratável. Pode apresentar várias manifestações, consoante o seu estadio – primário, secundário ou latente. O fenómeno de prozona é uma situação rara em que, pelo excesso de anticorpos na sífilis secundária, o VDRL apresenta um resultado qualitativo falso-negativo. Este caso clínico tem como objetivo sensibilizar para a existência deste fenómeno e da importância do senso clínico. Descrição do caso: Utente do sexo masculino de 44 anos, sem antecedentes relevantes, recorre a consulta de doença aguda por lesões cutâneas dispersas pela face, tórax, dorso e membros superiores com um mês de evolução, associadas a quadro sistémico de artralgias, mialgias, sensação de perda de peso, adenopatias axilares e inguinais, cefaleias frontais, lacrimejo bilateral e zumbido. Na anamnese, o utente refere episódio de ida ao serviço de urgência, cerca de cinco meses antes, por aparecimento de lesão peniana indolor, tendo sido medicado com antibioterapia com posterior resolução da mesma. Menciona ainda a prática de relações sexuais desprotegidas. Perante a suspeita de sífilis, em fase secundária, foram solicitadas análises sanguíneas que revelaram VDRL não reativo e, para além disso, alterações hepáticas significativas. Dada a evolução incongruente da marcha diagnóstica, o utente foi enviado ao serviço de urgência, onde se confirmou o diagnóstico de sífilis secundária por reatividade do VDRL, TPHA e anticorpo anti-Treponema pallidum. Comentário: Este caso demonstra a importância da priorização do senso clínico ao invés dos meios complementares de diagnóstico que, pelo seu resultado aparentemente contraditório, poderia ter alterado a conduta médica e, em última instância, a latência no diagnóstico e orientação terapêutica do utente, com potenciais complicações a longo prazo, nomeadamente o desenvolvimento de sífilis terciária.
A new future for family medicine/general practice in Portugal
Authors:   Médico de Medicina Geral e Familiar, Correia Gil , Jacinto Nuno ,   Médico de Medicina Geral e Familiar, Reis André ,   Médico de Medicina Geral e Familiar, Pereira António ,   Médico de Medicina Geral e Familiar, Broeiro-Gonçalves Paula ,   Médico de Medicina Geral e Familiar, Simões Susete ,   Médico de Medicina Geral e Familiar, Monteiro Nina ,   Médico de Medicina Geral e Familiar, Outeirinho Conceição ,   Médico de Medicina Geral e Familiar, Velho Denise ,   Médico de Medicina Geral e Familiar, Santos Mário ,   Médico de Medicina Geral e Familiar, Cruz Ana Margarida ,   Médico de Medicina Geral e Familiar, Ferreira Carina ,   Médico de Medicina Geral e Familiar, Mestre Carlos ,   Médico de Medicina Geral e Familiar, Jasmins Clara ,   Médico de Medicina Geral e Familiar, Torres Joana Romeira ,   Médico de Medicina Geral e Familiar, Rosendo Inês ,   Médico de Medicina Geral e Familiar, Silva Vera ,   Médico de Medicina Geral e Familiar
Published: September 2024

The ‘Blue Book’: a Future for Family Medicine in Portugal, edited in 1990 by the Portuguese Association of General Practice and Family Medicine, influenced the subsequent years and built the foundation for the Primary Healthcare Reform, initiated in 2005, but not fully implemented. In the current moment of low professional satisfaction, reviewing the principles that should guide family medicine in the future is important. The family doctor is the individual’s physician, who accompanies people's health throughout their life. Family doctors are specialists in primary healthcare and act according to the core values of family medicine as defined by the WONCA. Their actions form the basis of the health system and are associated with better health outcomes. Therefore, their actions must be centered on the person and the provision of differentiated care, reducing bureaucratic tasks and those with low health value. Physical spaces, equipment, and human resources should be adequately ensured, including the adjustment of the size of patients’ lists to ensure quality and dignified work by the Family Doctor, in every working setting. The Portuguese Association of General Practice and Family Medicine advocates for a performance-based remuneration model appropriate to the family doctor’s activity that compensates and prioritizes value-based healthcare, focusing their actions on the individual and reducing inefficiencies and duplications. This model is based on a new, simplified, and modern quality system grounded in the classic Structure – Process – Results framework but considering the dimensions of patient and professional satisfaction and adequately rewarding clinical work, teamwork, and citizen-centeredness. The present document is an adaptation and translation into English of the book 'A New Future for General and Family Medicine', edited by the Portuguese Association of General Practice and Family Medicine, in 2023.
Analisis Portofolio Optimal dengan Metode Liquidity Adjusted Capital Asset Pricing Model Pada Indeks Saham LQ-45
Authors: Safira Shafa Alya , Satyahadewi Neva , Huda Nur'ainul Miftahul
Published: September 2024

Investor wajib mempunyai kemampuan analisis terhadap hubungan diantara return yang diharapkan dan risiko. Salah satu model yang dikembangkan dalam pembentukan portofolio optimal adalah Liquidity Adjusted Capital Asset Pricing Model (LCAPM). LCAPM adalah model CAPM yang dipengaruhi oleh risiko likuiditas. Dalam penelitian, dilakukan pembentukan bobot optimal menggunakan LCAPM untuk indeks saham LQ-45 periode Februari 2019-Januari 2022. Penelitian ini bertujuan membentuk portofolio optimal indeks saham LQ-45 dan menerapkan LCAPM pada pengambilan keputusan investasi saham. Teknik pengambilan sampel pada penelitian ini menggunakan purposive sampling. Langkah penelitian setelah data terkumpul yaitu menghitung return harga penutupan indeks saham LQ-45, return pasar (IHSG), uji signifikan parameter, menghitung likuiditas saham serta likuiditas pasar, return bebas risiko, nilai beta saham, serta expected return dan memilih saham yang memiliki expected return yang bernilai positif untuk dibentuk portofolio. Kemudian dilakukan penyusunan kombinasi, pembobotan serta pengukuran kinerja portofolio. Hasil penelitian menunjukkan dari ketiga portofolio yang terbentuk memiliki nilai indeks sharpe yang bernilai negatif.. Investor lebih baik berinvestasi di bank yang menghasilkan expected return lebih tinggi dibanding portofolio saham yang dibentuk.
ЛОГІСТИЧНИЙ ЦЕНТР ЯК ОБ‘ЄКТ АЛЬТЕРНАТИВНОГО ІНВЕСТУВАННЯ В КРИЗОВИХ УМОВАХ
Authors: Сенів Л.А.
Published: September 2024

Динамічне функціонування світових логістичних систем засвідчує важливість процесу розвитку логістичних комплексів як об’єктів альтернативного інвестування в умовах створення сприятливого бізнес-клімату, покращення транспортно-логістичних зв‘язків та злиття світових економік. Дослідження становлення та розвитку логістичних центрів в Україні протягом кризового періоду (пандемія та російсько-українська війна) показало повільну трансформацію вітчизняної логістично-інфраструктурної мережі, фрагментарне законодавство у сфері транспортної логістики; незадовільний стан ведення бізнесу та наявність інвестиційних ризиків логістичної сфери. Проведення модернізації логістичної інфраструктури урядом України шляхом створення умов для сприятливого бізнес-середовища, страхування державою інвестиційних проєктів та реалізація проєктів логістично-транспортної галузі на засадах державно-приватного партнерства забезпечить залучення альтернативних інвестицій в нерухомість, що зумовить розвиток вітчизняних логістичних центрів.
THE THEORETICAL ESSENCE OF THE ORGANIZATIONAL AND ECONOMIC MECHANISM
Authors:   Mukachevo State University, Hladynets Natalia , Kuzmenko Volodymyr ,   Mukachevo State University
Published: September 2024

The article updates the organizational and economic mechanism as a tool for ensuring effective economic development, reflects the contribution of domestic economists in the research of this category. The article shows the theoretical essence of the organizational-economic mechanism, its evolution, ontology, highlights the analysis of the categories "organizational mechanism" and "economic mechanism" separately, gives the views of domestic and foreign scientists on their definition using tables and features of these views. The peculiarities of the economic mechanism are outlined in detail (the economic mechanism is formed as a result of the subjective activity of people, which is connected with the transformation of production resources; the economic mechanism as a system has a complex structure; the economic mechanism is an integral process of implementing existing methods, principles, functions and management tools , regulation and influence at all levels of the economy). The article illustrates the concepts of foundational scientists and winners of the Nobel Prize in Economics for their fundamental contribution to the theory of economic mechanisms and their design, the genesis of the concept of organizational-economic mechanism. A road map for the creation of an organizational mechanism has been developed, consisting of eleven consecutive stages (research and analysis, study of the problem, opposition, formulation of solutions-proposals, design, analysis of effectiveness, decision-making, organization, control, analysis of results, functioning of the organizational mechanism). An own approach to the definition of the category of "organizational and economic mechanism" is presented based on the analyzed views of scientists and formed own definitions of the categories "organizational mechanism" and "economic mechanism". The structure of the organizational-economic mechanism is outlined on the basis of four blocks (forms and methods, levers and tools, economic indicators, management system) and the elements of each of its blocks are characterized separately in order to effectively model and understand the processes of the organizational-economic mechanism. The article emphasizes the importance of the organizational and economic mechanism and its significant influence in order to ensure the effective genesis of the country's economy in the global hybrid modern environment.
Full genomic profiling of gene expression in selected muscle tissue biopsy specimens from myofascial pain syndrome (pilot comparison of muscle biopsy transcriptomes)
Authors: Safiullina A. А. , Cherepnev G. V. , Safiullina G. I. , Vlasenkova R. A.
Published: September 2024

Introduction. Myofascial pain syndrome (MFPS) is one of the most frequent musculoskeletal pathologies causing chronic pain. This type of pain reaches the peak of prevalence in middle-aged individuals, women are affected 2,5 times more often than men. The disease leads to significant disability and is not only a medical but also a social problem. At the same time, a number of authors still note the low clinical efficacy of the applied therapy schemes. In this situation, further study of the pathogenesis of MFPS, in particular, genetic aspects of realization of this condition.

The aim of the study was to perform full genomic profiling of gene expression (transcriptome study) in selected muscle tissue biopsy specimens of individual patients and control individuals.

Materials and methods. To study the genetic aspects of MFPS realization, gene expression profiling in muscle tissue samples by full genome RNA sequencing (RNA-Seq) was performed in 5 patients suffering from myofascial brachial pain syndrome (2 patients with active form of MFPS, 3 — with latent form).

Results. The transcriptome analysis of muscle tissue samples from the MFPS area revealed a statistically significant 6-10-fold increase in the expression of the ENSG00000148677:ANKRD1 (ankyrin repeat domain 1) gene in the subgroup of patients with latent form of MFPS compared to active form of MFPS.

Conclusion. The results of the studies allowed to suggest that one of the factors of the latent form of MFPS realization may be adaptive hyperexpression of the gene encoding ANKRD1 protein, which regulates myofibrils tension, myoblasts differentiation, lipid metabolism, affects the development of neuronal connections.
Morphofunctional indicators of the body students of the medical university
Authors: Kalyuzhny E. A. , Bogomolova E. S. , Mukhina I. V. , Galova E. А. , Basurov V. A. , Nazarova N. A.
Published: September 2024

Introduction. The period of adolescence accounts for the completion of the growth processes of the body, and the beginning of stabilization of functional indicators, which, as more plastic factors, are more sensitive to environmental conditions. Measuring, evaluating, and predicting morphofunctional parameters of the body of medical university students, taking into account regional standards of physical development, is one of the priorities of modern medicine and scientific research in general.

The aim of the study is to study the features of anthropometric and functional characteristics, vegetotype of medical university students in comparison with the current regional standard.

Materials and methods. Anthropometric and functional parameters were measured in 300 medical students (77 males, 223 females), aged 19,1±0,88 years.

Results. It is shown that anthropometric characteristics of students significantly exceed the regional standard, in boys it is body length (p<0,01), and weight-height ratio (p<0,05), in girls it is body length, chest circumference and weight-height ratio (p<0,01). Cardiointervalography parameters revealed 4,01 % vagotonics, 88,33 % eutonics and 7,62 % sympathotonics, a significant difference (p<0,01) was also found in linear cardiointervalogram parameters in cohorts of these vegetotypes. Functional indices in absolute terms revealed compliance with the regional standard only in vital capacity of lungs, carpal dynamometry is significantly lower than the standard, in girls (p<0,01), boys (p<0,05), haemodynamics in terms of diastolic blood pressure and heart rate significantly (p<0,01) exceeds the reference values. Integral functional indices: vital index, vegetative index, minute volume of respiration differ significantly by sex (p<0,05); Kerdo index, minute volume of blood circulation showed a significant difference by vegetotype (p<0,05); pulse pressure showed a significant difference by sex and vegetotype (p<0,01).

Conclusion. The studies showed statistically significant excesses relative to the regional standard in young men in body length (p<0,01) and mass-height ratio (p<0,05), in chest circumference in girls (p<0,01); in diastolic blood pressure and heart rate in boys and girls (p<0,01). Absolute and integral indices of cardio-respiratory system are significantly higher in sympathotonics than in vagotonics. Young men, relative to girls, demonstrate higher absolute, linear values of cardiointervalogram (p<0,01), in the whole population these indices are within the range of norm of the regional standard. Among students the majority 88,33 % have normotonic type of ANS. The obtained results, in our opinion, show the need for systematic monitoring of objective morphofunctional state of modern youth.
Research progress of stem cell therapy for neurological diseases
Authors: Usman Taj Muhammad , Asim Muhammad
Published: September 2024

Neurological diseases are considered one of the leading causes of death and disability worldwide; not only do patients suffer, but they also place a significant economic burden on families and society. Traditional medications now show limited efficacy, and surgical interventions can be dangerous. The need to develop new medicines is critical as more people become aware of the immense burden this disease imposes on society and the limited number of viable therapeutic options that currently exist. Modern research is increasingly focusing on novel and potent approaches to treat neurological illnesses to address these challenges. One promising method is the stem cell-based therapy. The development of stem cell transplantation techniques and cellular therapies in recent years has provided new hope for the treatment of neurological disorders. Stem cell therapies have demonstrated therapeutic potential in animal models, and different types of stem cells have been used in clinical trials. In this study, we explored the applications of mesenchymal stem cells, dental pulp stem cells, and induced pluripotent stem cells in neurological diseases. In recent years, we have examined the current status and progress of stem cell applications in treating neurological diseases, both domestically and internationally, and reviewed some of the key challenges encountered.
Simulation and Experimental Analysis of Electrical Characterization of Cap-Pin Glass Insulator under Uniform and Non-Uniform Pollution Layers
Authors: Salhi Rabie , Mekhaldi Abdelouahab , Teguar Madjid , Kherif Omar
Published: September 2024

This paper deals with the analysis of the electrical performance of the glass cap-pin insulator under pollution conditions. The experiments are conducted in accordance with the IEC 60815 standard using artificial pollution (a distilled water mixture with NaCl). Several levels of applied voltage are used to evaluate the impact of both uniform and non-uniform pollution. For the same conditions, simulations are carried out using the COMSOL Multiphysics environment. Of interest, Leakage current waveforms are extracted from the current density and compared to those obtained from experiments. A proposed process, which aims to predict the effectiveness of the simulation in selecting appropriate parameters, geometry, boundaries etc., is investigated, where the findings are closely match the real model. Therefore, the electric field distribution on the insulator surface is presented, and 3D representations are considered for better visualizing the influence of the pollution on the insulating system. Accordingly, arcing discharges are characterized by high levels of electric field stress for uniform pollution, and dry-band arcing is simulated to correspond perfectly with laboratory findings for non-uniform pollution. Finally, this paper provides valuable insights into the electrical stress on the insulator under the effect of pollution conditions.
أثر تمرينات خاصة وفقا لمجالات وقفة حارس المرمى في تطوير اداء رمية (7م) بكرة اليد للاعبين بأعمار (16-18) سنة
Authors: Ali Muhammad Hussein  , Prof. Dr. Samer Youssef Muteab
Published: September 2024

ان العملية التعليمية يجب ان تركز على اعداد اللاعبين للمواقف المختلفة اعدادا جيدا سواء فيما يخص حارس المرمى او الاعبين المنفذين لرميات ٧متر. من خلال متابعة الباحثان الحثيثة لكرة اليد العالمية وللاعبين بأعمار (16-18) سنة في العراق لاحظوا عدم وجود اسس تعليمية او قواعد للأداء والكيفية التي يتعامل بها اللاعب في اداء رمية ٧ متر في بلدنا الحبيب حيث التعامل الاني والذاتي مع الموقف دون الرجوع الى اسس تم التدريب عليها بسبب عدم تحديدها ومعرفتها سابقا سواء كانت تتعلق بحارس المرمى او اللاعب المنفذ. وهذه الحالة تم تشخيصها ايضاً بشكل خاص لدى لاعبي فريق نادي القاسم الشباب. وكذلك تم تشخيص وجود ضعف في تنفيذ هذه الرمية المهمة. ويهدف البحث الى معرفة أثر التمرينات الخاصة في تطوير اداء رمية ال (7) متر لدى لاعبي كرة اليد بأعمار (16-18) سنة. واستخدم الباحثان المنهج التجريبي بتصميم المجموعتين المتكافئتين (التجريبية والضابطة) ذات الاختبارات القبلية والبعدية لملائمته لطبيعة ومشكلة البحث، وحدد مجتمع البحث بلاعبي نادي القاسم بكرة اليد فئة الشباب والبالغ عددهم (١٤) لاعب اما عينة البحث تم اختيارها بأسلوب الحصر الشامل بنسبة (١٠٠٪) من مجتمع الاصل وقسمت العينة الى بالطريقة العشوائية البسيطة (القرعة) مجموعة تجريبية (٧) لاعبين ومجموعة ضابطة (٧) لاعبين. واستخدمت الحقيبة الإحصائية (SPSS) لغرض معالجة البيانات.
Закономірності деформування пневматичної ресори швидкісного рухомого складу у залежності від внутрішнього тиску та прикладеного зовнішнього статичного навантаження
Authors: Кузишин А.Я. , Ковальчук В.В.
Published: September 2024

Основою безпечної експлуатації сучасногошвидкісного рухомого складу залізниць є дотриманняйого динамічних показників та показників безпекируху. Метою статті є дослідженнязакономірностей деформування гумо-кордноїоболонки пневматичної ресори сучасногошвидкісного рухомого складу залізниць в залежностівід величини прикладеного зовнішньогонавантаження та внутрішнього тиску в ресорі. Длядосягнення цієї мети було розроблено спеціальнуконструкцію стенду та програмуекспериментальних випробувань пневматичноїресори, яка передбачала вимірювання вертикальнихта горизонтальних деформацій із застосуваннямсучасних вимірювальних технологій. Зміна величинвнутрішнього тиску та прикладеного зовнішньогонавантаження відбувалась за допомогоюкомпресора високого тиску та гідродомкратувідповідно. Для вимірювання вертикальних тагоризонтальних деформацій застосовувалисьвисокочастотні датчики лінійних переміщень.Внутрішній тиск у ресорі змінювався ступеня ізкроком 0,5 атм. На основі проведених дослідженьпобудовано залежності вертикального переміщеннякріпильної плити, а також вертикального тагоризонтального деформування нижньої частинигумо-кордної оболонки від величини манометричноготиску у пневматичній ресорі. Встановлено, щозбільшення величини манометричного тиску впневматичній ресорі призводить до зменшеннямаксимальної сили зовнішнього навантаження, щонеобхідно для деформування ресори на її граничнувеличину. Відзначено певні узгодження міждеформуванням гумо-кордної оболонки угоризонтальному напрямку з різницею міжвертикальним переміщенням кріпильної плити тадеформуванням нижньої частини гумо-кордноїоболонки у вертикальному напрямку. Науковановизна отриманих результатів полягає уекспериментальному встановленні закономірностейдеформування гумо-кордної оболонки пневматичноїресори у вертикальному та горизонтальномунапрямках у залежності від зміни тиску впневматичній ресорі та прикладеного зовнішньогонавантаження. Що дозволить більш точномоделювати роботу пневматичної ресори ізурахуванням особливостей деформування гумо-кордної оболонки та визначати її динамічніхарактеристики, що необхідно на етапіпроектування сучасного швидкісного рухомогоскладу залізниць при визначенні безпечних умов йогоексплуатації.