bluuebunny/crossref_metadata_2025 huggingface dataset:
Alcohol use during pregnancy in Rakai, Uganda
Authors: Wynn Adriane , Nabukalu Dorean , Lutalo Tom , Wawer Maria , Chang Larry W. , Kiene Susan M. , Serwadda David M. , Sewankambo Nelson , Nalugoda Fred , Kigozi Godfrey , Wagman Jennifer A.
Published: August 2021

Introduction

Antenatal alcohol use is linked to adverse maternal and neonatal outcomes. Uganda has one of the highest rates of alcohol use in sub-Saharan Africa, but the prevalence of antenatal alcohol use has not been reported in the Rakai region.

Methods

We used cross-sectional data from pregnant women in the Rakai Community Cohort Study between March 2017 and September 2018. Using bivariate and multivariable analyses, we assessed associations between self-reported antenatal alcohol use and sociodemographic characteristics, intimate partner violence (IPV), and HIV status.

Results

Among 960 pregnant women, the median age was 26 years, 35% experienced IPV in the past 12 months, 13% were living with HIV, and 33% reported alcohol use during their current pregnancy. After adjusting for marital status, education, smoking, and HIV status; Catholic religion (AOR: 3.54; 95% CI: 1.89–6.64; compared to other), bar/restaurant work (AOR: 2.40; 95% CI: 1.17–4.92; compared to agriculture), >one sex partner in past year (AOR: 1.92; 95% CI: 1.17–3.16), a partner that drank before sex in past year (AOR: 2.01; 95% CI: 1.48–2.74), and past year IPV (AOR: 1.55; 95% CI: 1.14–2.11) were associated with antenatal alcohol use.

Conclusion

We found that alcohol use during pregnancy was common and associated with religion, occupation, higher numbers of past year sex partners, having a partner who drank before sex in the past 12 months, and IPV experience. More research is needed to understand the quantity, frequency, and timing of antenatal alcohol use; and potential impacts on neonates; and to identify services that are acceptable and effective among pregnant women.
Neutrophil gelatinase-associated lipocalin partly reflects the dynamic changes of renal function among chronic hepatitis C patients receiving direct-acting antivirals
Authors: Chen Yen-Chun , Li Chen-Hao , Ko Ping-Hung , Lee Chi-Che , Syu Ru-Jiang , Tseng Chih-Wei , Tseng Kuo-Chih
Published: August 2021

Background

Changes in renal function in chronic hepatitis C (CHC) patients receiving direct-acting antivirals (DAAs) are controversial. The evolution of neutrophil gelatinase-associated lipocalin (NGAL) in these patients remains unclear.

Methods

A total of 232 CHC patients receiving DAA at Dalin Tzu Chi Hospital from May 2016 to February 2019, were enrolled in this retrospective study. Grade 2/3 renal function deterioration, defined as a decrease in eGFR between 10% and 50% from baseline (BL) to 12 weeks after the end of treatment (P12), was investigated for its association with BL characteristics. The changes in renal function and NGAL levels were also analyzed at the SOF-base or nonSOF-base DAA.

Results

Sixty-two patients (26.7%) had grade 2/3 renal function deterioration at P12 after DAA therapy. Univariate analysis showed that it was associated with age (P = 0.038). Multivariate analysis indicated that age (OR = 1.033, 95% CI: 1.004–1.064, P = 0.027), sex (male; OR = 2.039, 95% CI: 1.093–3.804, P = 0.025), ACEI/ARB use (OR = 2.493, 95% CI: 1.016–6.119, P = 0.046), and BL NGAL (OR = 1.033, 95% CI: 1.001–1.067, P = 0.046) positively correlated with grade 2/3 renal function deterioration. Furthermore, eGFR was decreased (P = 0.009) and NGAL was increased (P = 0.004) from BL to P12 in CHC patients receiving SOF-based DAA.

Conclusions

Of the CHC patients receiving DAA therapy, 26.7% had grade 2/3 renal function deterioration at P12, and it was associated with older age, gender being male, ACEI/ARB use, and higher BL NGAL levels. In addition, NGAL might be a biomarker of nephrotoxicity at P12 in patients receiving SOF-based DAA.
Daily social interactions related to daily performance on mobile cognitive tests among older adults
Authors: Zhaoyang Ruixue , Scott Stacey B. , Martire Lynn M. , Sliwinski Martin J.
Published: August 2021

The lack of social contact or good social relationships has been linked with cognitive decline and higher risk for Alzheimer’s disease and related dementias. One important but unexamined question is how daily social interactions relate to older adults’ cognitive function in daily life. The present study examined how changes in daily social interactions related to fluctuations in older adults’ performance on mobile cognitive tests from day to day. Using an ecological momentary assessments approach, 312 older adults (aged 70 to 90 years) completed surveys on social interactions and mobile cognitive tests five times a day for 16 consecutive days using smartphones. Multilevel modeling was used for analyses. Results demonstrated that having more daily social interactions, especially more pleasant social interactions, related to better cognitive performance the same day and over the subsequent two days. Cognitive performance, however, did not predict subsequent changes in social interactions across days. At the between-person level, older adults who had more (vs. less) frequent interactions with close partners on average, especially with their friends, had better cognitive performance. Finally, the average levels of social interactions also moderated the within-person associations between daily social interactions and the same-day cognitive performance. In sum, results from this study highlight the importance of having pleasant social interactions and frequent interactions with friends for older adults’ cognitive function in daily life, and have important implications for future behavioral interventions targeting certain features of daily social interactions to reduce risk of cognitive decline and Alzheimer’s disease and related dementias.
A data assimilation framework that uses the Kullback-Leibler divergence
Authors: Pimentel Sam , Qranfal Youssef
Published: August 2021

The process of integrating observations into a numerical model of an evolving dynamical system, known as data assimilation, has become an essential tool in computational science. These methods, however, are computationally expensive as they typically involve large matrix multiplication and inversion. Furthermore, it is challenging to incorporate a constraint into the procedure, such as requiring a positive state vector. Here we introduce an entirely new approach to data assimilation, one that satisfies an information measure and uses the unnormalized Kullback-Leibler divergence, rather than the standard choice of Euclidean distance. Two sequential data assimilation algorithms are presented within this framework and are demonstrated numerically. These new methods are solved iteratively and do not require an adjoint. We find them to be computationally more efficient than Optimal Interpolation (3D-Var solution) and the Kalman filter whilst maintaining similar accuracy. Furthermore, these Kullback-Leibler data assimilation (KL-DA) methods naturally embed constraints, unlike Kalman filter approaches. They are ideally suited to systems that require positive valued solutions as the KL-DA guarantees this without need of transformations, projections, or any additional steps. This Kullback-Leibler framework presents an interesting new direction of development in data assimilation theory. The new techniques introduced here could be developed further and may hold potential for applications in the many disciplines that utilize data assimilation, especially where there is a need to evolve variables of large-scale systems that must obey physical constraints.
Beta diversity differs among hydrothermal vent systems: Implications for conservation
Authors: Giguère Thomas N. , Tunnicliffe Verena
Published: August 2021

Deep-sea hydrothermal vent habitats are small, rare and support unique species through chemosynthesis. As this vulnerable ecosystem is increasingly threatened by human activities, management approaches should address biodiversity conservation. Diversity distribution data provide a useful basis for management approaches as patterns of β-diversity (the change in diversity from site to site) can guide conservation decisions. Our question is whether such patterns are similar enough across vent systems to support a conservation strategy that can be deployed regardless of location. We compile macrofaunal species occurrence data for vent systems in three geological settings in the North Pacific: volcanic arc, back-arc and mid-ocean ridge. Recent discoveries in the Mariana region provide the opportunity to characterize diversity at many vent sites. We examine the extent to which diversity distribution patterns differ among the systems by comparing pairwise β-diversity, nestedness and their additive components. A null model approach that tests whether species compositions of each site pair are more or less similar than random provides insight into community assembly processes. We resolve several taxonomic uncertainties and find that the Mariana arc and back-arc share only 8% of species despite their proximity. Species overlap, species replacement and richness differences create different diversity distributions within the three vent systems; the arc system exhibits much greater β-diversity than both the back-arc and mid-ocean ridge systems which, instead, show greater nestedness. The influence of nestedness on β-diversity also increased from the arc to back-arc to ridge. Community assembly processes appear more deterministic in the arc and ridge systems while back-arc site pairs deviate little from the null expectation. These analyses reflect the need for a variety of management strategies that consider the character of diversity distribution to protect hydrothermal vents, especially in the context of mining hydrothermal deposits.
CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2
Authors: Nagar Harsha , Kim Seonhee , Lee Ikjun , Choi Su-Jeong , Piao Shuyu , Jeon Byeong Hwa , Shong Minho , Kim Cuk-Seong
Published: August 2021

Rho GDP-dissociation inhibitor (RhoGDI), a downregulator of Rho family GTPases, prevents nucleotide exchange and membrane association. It is responsible for the activation of Rho GTPases, which regulate a variety of cellular processes, such as migration. Although RhoGDI2 has been identified as a tumor suppressor gene involved in cellular migration and invasion, little is known about its role in vascular endothelial cell (EC) migration. CR6-interacting factor 1 (CRIF1) is a CR6/GADD45-interacting protein with important mitochondrial functions and regulation of cell growth. We examined the expression of RhoGDI2 in CRIF1-deficient human umbilical vein endothelial cells (HUVECs) and its role in cell migration. Expression of RhoGDI2 was found to be considerably higher in CRIF1-deficient HUVECs along with suppression of cell migration. Moreover, the phosphorylation levels of Akt and CREB were decreased in CRIF1-silenced cells. The Akt-CREB signaling pathway was implicated in the changes in endothelial cell migration caused by CRIF1 downregulation. In addition to RhoGDI2, we identified another factor that promotes migration and invasion of ECs. Adrenomedullin2 (ADM2) is an autocrine/paracrine factor that regulates vascular tone and other vascular functions. Endogenous ADM2 levels were elevated in CRIF1-silenced HUVECs with no effect on cell migration. However, siRNA-mediated depletion of RhoGDI2 or exogenous ADM2 administration significantly restored cell migration via the Akt-CREB signaling pathway. In conclusion, RhoGDI2 and ADM2 play important roles in the migration of CRIF1-deficient endothelial cells.
The Community Assessment of Psychic Experiences-Positive scale (CAPE-P15) accurately classifies and differentiates psychotic experience levels in adolescents from the general population
Authors: Núñez D. , Godoy M. I. , Gaete J. , Faúndez M. J. , Campos S. , Fresno A. , Spencer R.
Published: August 2021

Background

There is increasing interest in studying psychotic symptoms in non-clinical populations, with the Community Assessment of Psychic Experiences-Positive scale (CAPE-P15) being one of the self-screening questionnaires used most commonly for this purpose. Further research is needed to evaluate the ability of the scale to accurately identify and classify positive psychotic experiences (PE) in the general population.

Aim

To provide psychometric evidence about the accuracy of the CAPE-P15 for detecting PE in a sample of Chilean adolescents from the general population and classifying them according to their PE severity levels.

Method

We administered the CAPE-P15 to a general sample of 1594 students aged 12 to 19. Based on Item Response Theory (IRT), we tested the accuracy of the instrument using two main parameters: difficulty and discrimination power of the 15 items.

Results

We found that the scale provides very accurate information about PE, particularly for high PE levels. The items with the highest capability to determine the presence of the latent trait were those assessing perceptual anomalies (auditory and visual hallucinations), bizarre experiences (a double has taken the place of others; being controlled by external forces), and persecutory ideation (conspiracy against me).

Conclusions

The CAPE-P15 is an accurate and suitable tool to screen PE and to accurately classify and differentiate PE levels in adolescents from the general population. Further research is needed to better understand how maladaptive psychological mechanisms influence relationships between PE and suicidal ideation (SI) in the general population.
Rosetta:MSF:NN: Boosting performance of multi-state computational protein design with a neural network
Authors: Nazet Julian , Lang Elmar , Merkl Rainer
Published: August 2021

Rational protein design aims at the targeted modification of existing proteins. To reach this goal, software suites like Rosetta propose sequences to introduce the desired properties. Challenging design problems necessitate the representation of a protein by means of a structural ensemble. Thus, Rosetta multi-state design (MSD) protocols have been developed wherein each state represents one protein conformation. Computational demands of MSD protocols are high, because for each of the candidate sequences a costly three-dimensional (3D) model has to be created and assessed for all states. Each of these scores contributes one data point to a complex, design-specific energy landscape. As neural networks (NN) proved well-suited to learn such solution spaces, we integrated one into the frameworkRosetta:MSFinstead of the so far used genetic algorithm with the aim to reduce computational costs. As its predecessor,Rosetta:MSF:NNadministers a set of candidate sequences and their scores and scans sequence space iteratively. During each iteration, the union of all candidate sequences and their Rosetta scores are used to re-train NNs that possess a design-specific architecture. The enormous speed of the NNs allows an extensive assessment of alternative sequences, which are ranked on the scores predicted by the NN. Costly 3D models are computed only for a small fraction of best-scoring sequences; these and the corresponding 3D-based scores replace half of the candidate sequences during each iteration. The analysis of two sets of candidate sequences generated for a specific design problem by means of a genetic algorithm confirmed that the NN predicted 3D-based scores quite well; the Pearson correlation coefficient was at least 0.95. ApplyingRosetta:MSF:NN:enzdesto a benchmark consisting of 16 ligand-binding problems showed that this protocol converges ten-times faster than the genetic algorithm and finds sequences with comparable scores.
Susceptibility of subregions of prefrontal cortex and corpus callosum to damage by high-dose oxytocin-induced labor in male neonatal mice
Authors: Kitamura Eri , Koike Masato , Hirayama Takashi , Sunabori Takehiko , Kameda Hiroshi , Hioki Hiroyuki , Takeda Satoru , Itakura Atsuo
Published: August 2021

Induction and augmentation of labor is one of the most common obstetrical interventions. However, this intervention is not free of risks and could cause adverse events, such as hyperactive uterine contraction, uterine rupture, and amniotic-fluid embolism. Our previous study using a new animal model showed that labor induced with high-dose oxytocin (OXT) in pregnant mice resulted in massive cell death in selective brain regions, specifically in male offspring. The affected brain regions included the prefrontal cortex (PFC), but a detailed study in the PFC subregions has not been performed. In this study, we induced labor in mice using high-dose OXT and investigated neonatal brain damage in detail in the PFC using light and electron microscopy. We found that TUNEL-positive or pyknotic nuclei and Iba-1-positive microglial cells were detected more abundantly in infralimbic (IL) and prelimbic (PL) cortex of the ventromedial PFC (vmPFC) in male pups delivered by OXT-induced labor than in the control male pups. These Iba-1-positive microglial cells were engulfing dying cells. Additionally, we also noticed that in the forceps minor (FMI) of the corpus callosum (CC), the number of TUNEL-positive or pyknotic nuclei and Iba-1-positive microglial cells were largely increased and Iba-1-positive microglial cells phagocytosed massive dying cells in male pups delivered by high-dose OXT-induced labor. In conclusion, IL and PL of the vmPFC and FMI of the CC, were susceptible to brain damage in male neonates after high-dose OXT-induced labor.
miR-155 T/A (rs767649) and miR-146a A/G (rs57095329) single nucleotide polymorphisms as risk factors for chronic hepatitis B virus infection among Egyptian patients
Authors: Hefzy Enas M. , Hassuna Noha A. , Shaker Olfat G. , Masoud Mohamed , Abelhameed Tebyan A. , Ahmed Tarek I. , Hemeda Nada F. , Abdelhakeem Mohammed A. , Mahmoud Rania H.
Published: August 2021

Genetic variants in microRNAs (miRNAs) can alter the miRNAs expression and/or function, accordingly, affecting the related biological pathways and disease risk. Dysregulation of miR-155 and miR-146a expression levels has been well-described in viral hepatitis B (HBV). In the current study, we aimed to assess rs767649 T/A and rs57095329 A/G polymorphisms in miR-155, and miR-146a genes, respectively, as risk factors for Chronic HBV (CHBV) in the Egyptian population. Also, we aimed to do in silico analysis to investigate the molecules that primarily target these miRNAs. One hundred patients diagnosed as CHBV and one hundred age and sex-matched controls with evidence of past HBV infection were genotyped for miR-155 (rs767649) and miR-146a (rs57095329) using real-time polymerase chain reaction. The rs767649 AT and AA genotypes in CHBV patients confer four folds and ten folds risk respectively, as compared to control subjects [(AOR = 4.245 (95%CI 2.009–8.970), p<0.0001) and AOR = 10.583 (95%CI 4.012–27.919), p<0.0001, respectively)]. The rs767649 A allele was associated with an increased risk of developing CHBV (AOR = 2.777 (95%CI 1.847–4.175), p<0.0001). There was a significant difference in the frequency of rs57095329 AG and GG genotypes in CHBV patients compared to controls. AG and GG genotypes showed an increase in the risk of developing CHBV by about three and six folds respectively [AOR = 2.610 (95%CI 1.362–5.000), p = 0.004] and [AOR = 5.604 (95%CI 2.157–14.563), p<0.0001].We concluded that rs57095329 and rs767649 SNPs can act as potential risk factors for the development of CHBV in the Egyptian population.
Gender imbalance amongst promotion and leadership in academic surgical programs in Canada: A cross-sectional Investigation
Authors: Hunter Jennifer , Crofts Helen , Keehn Alysha , Schlagintweit Sofie , Luc Jessica G. Y. , Lefaivre Kelly A.
Published: August 2021

Background

Women are underrepresented at higher levels of promotion or leadership despite the increasing number of women physicians. In surgery, this has been compounded by historical underrepresentation. With a nation-wide focus on the importance of diversity, our aim was to provide a current snapshot of gender representation in Canadian universities.

Methods

This cross-sectional online website review assessed the current faculty listings for 17 university-affiliated academic surgical training departments across Canada in the 2019/2020 academic year. Gender diversity of academic surgical faculty was assessed across surgical disciplines. Additionally, gender diversity in career advancement, as described by published leadership roles, promotion and faculty appointment, was analyzed.

Results

Women surgeons are underrepresented across Canadian surgical specialties (totals: 2,689 men versus 531 women). There are significant differences in the gender representation of surgeons between specialties and between universities, regardless of specialty. Women surgeons had a much lower likelihood of being at the highest levels of promotion (OR: 0.269, 95% CI: 0.179–0.405). Men surgeons were statistically more likely to hold academic leadership positions than women (p = 0.0002). Women surgeons had a much lower likelihood of being at the highest levels of leadership (OR: 0.372, 95% CI: 0.216–0.641).

Discussion

This study demonstrates that women surgeons are significantly underrepresented at the highest levels of academic promotion and leadership in Canada. Our findings allow for a direct comparison between Canadian surgical subspecialties and universities. Individual institutions can use these data to critically appraise diversity policies already in place, assess their workforce and apply a metric from which change can be measured.
How pharmacy and medicine students experience the power differential between professions: “Even if the pharmacist knows better, the doctor’s decision goes”
Authors: Thomas Josephine , Kumar Koshila , Chur-Hansen Anna
Published: August 2021

Interprofessional Education (IPE) is one approach to improving communication and collaborative practice between professions, which are essential for the optimal delivery of healthcare. Common barriers include negative attitudes, professional stereotypes, professional cultures and power differentials between professional groups. The aim of this qualitative study was to explore how professional hierarchies and power differentials shape interprofessional interactions between preregistration pharmacy and medicine students. Data were gathered via semi-structured interviews and subject to thematic analysis. Four main themes were identified: Reproducing traditional hierarchies; Social norms around respect; Hierarchies in care values and goals; and Challenging the narrative is possible. Students’ interactions with and views of the other profession largely reflected traditional stereotypes and power differentials. Hierarchy was evident in how respect was accorded and in how care values and goals were managed. Despite this, students overwhelmingly perceived and reported a sense of agency in changing the status quo. Emerging professional identity and conceptualisation of future roles is heavily influenced by the hierarchical relationship between the professions and can pose a significant barrier to collaborative practice. Greater support for collaborative interprofessional practice is needed at the level of policy and accreditation in health education and healthcare to ensure greater commitment to change.
Multiple states in ongoing neural activity in the rat visual cortex
Authors: Konno Daichi , Nishimoto Shinji , Suzuki Takafumi , Ikegaya Yuji , Matsumoto Nobuyoshi
Published: August 2021

The brain continuously produces internal activity in the absence of afferently salient sensory input. Spontaneous neural activity is intrinsically defined by circuit structures and associated with the mode of information processing and behavioral responses. However, the spatiotemporal dynamics of spontaneous activity in the visual cortices of behaving animals remain almost elusive. Using a custom-made electrode array, we recorded 32-site electrocorticograms in the primary and secondary visual cortex of freely behaving rats and determined the propagation patterns of spontaneous neural activity. Nonlinear dimensionality reduction and unsupervised clustering revealed multiple discrete states of the activity patterns. The activity remained stable in one state and suddenly jumped to another state. The diversity and dynamics of the internally switching cortical states would imply flexibility of neural responses to various external inputs.
American Literature in Transition, 1960–1970, David Wyatt (ed.) (2018)
Authors: Haslam Oliver
Published: August 2021

Review of: American Literature in Transition, 1960–1970, David Wyatt (ed.) (2018)

Cambridge: Cambridge University Press, 385 pp.,

ISBN 978-1-107-16539-7, h/bk, £89.99
Seropositivity and risk factors associated with the presentation of bovine leukosis virus in Sotaquirá, Colombia
Authors: Bulla-Castañeda Diana M. , Díaz-Anaya Adriana M. , Garcia-Corredor Diego J. , Tobón-Torreglosa Julio C. , Ortega Diego Ortiz , Pulido-Medellín Martín O.
Published: August 2021

Background and Aim: Enzootic bovine leukosis is a disease economically important to the dairy farming industry worldwide. The virus is of the Deltaretrovirus genus and is primarily transmitted iatrogenically. Most bovines infected with the virus remain asymptomatic with only 5-10% of cattle having lymphomas. This study aimed to determine the seroprevalence of bovine leukosis virus (BLV) in Sotaquirá, Boyacá, Colombia.

Materials and Methods: We conducted a descriptive, observational epidemiological cross-sectional study using the simple random sampling method with a sample size of 1000. Blood samples from random bovine were processed using the SERELISA® BLV Ab Mono Blocking indirect enzyme-linked immunosorbent assay kit (Zoetis, USA). The assay had a sensitivity of 97% and a specificity of 98%. The collected data were processed using Epi Info® (Centers for Disease Control and Prevention; Atlanta, Georgia). From the study, we could determine a high seroprevalence of BLV in Sotaquirá.

Results: We established a high seroprevalence on BLV in the municipality, with 31.1% apparent seroprevalence and 30.6% real seroprevalence rate. We found that male cattle more than 4 years old (39.4%) and the Ayrshire breed (45.5%) had the highest prevalence rates of the virus. In this study, we could establish statistically significant associations according to breed, age, and gender of the cattle under study. Moreover, we identified the risk factors for BLV infection. We found that in cattle aged <1 year and those older than 4 years of age and those of the Holstein breed, the presentation of infectious bovine rhinotracheitis, mucosal secretions, mastitis, fetal death, the presence of a corral, and the implementation of artificial insemination practices were risk factors for BLV infection.

Conclusion: Determining the prevalence of BLV within the herd and identifying the associated risk factors for the disease are fundamental in developing efficient programs for the control and eradication of BLV within herds.
Biomarkers in low cardiac output syndrome after open cardiac surgery in children
Authors: Kusumajaya Reby , Advani Najib , B. Yanuarso Piprim , Effendy Zulham
Published: August 2021

Background Corrective cardiac surgery is the standard management for complex congenital heart disease. Cardiopulmonary bypass surgery and post-surgical intensive care may lead to low cardiac output syndrome (LCOS), as a major complication after open heart surgery.  To diagnose early LCOS, lactate level, pCO2 gap, and mixed venous oxygen saturation (SvO2) are parameters reported to have correlations with decreased cardiac output, morbidity, and post-cardiac surgery mortality. Objective To determine the usefulness of lactate level, pCO2 gap (arterial-vein), and SvO2 for early detection of LCOS in children post-open heart surgery. Methods This prospective cohort study was done from August to October 2017 in the ICU of the Integrated Cardiac Center, Dr. Cipto Mangunkusumo Hospital, Jakarta. Subjects were pediatric patients who underwent cardiac surgery. After surgery, patients underwent monitoring in the ICU for clinical signs of LCOS and examinations for lactate levels, pCO2 gap, and SvO2 at 15 minutes, 4 hours and 8 hours. Results Thirty-three open heart surgery patients were the subjects. Lactate level at 4 hours and 8 hours post-operative were significantly higher in the LCOS group compared to non-LCOS group. For the pCO2 gap, only the 4-hour post-operative results were significantly higher in LCOS group compared to non-LCOS groups. In addition, only SvO2 at 4 hours after surgery was significantly lower in LCOS group compared to non-LCOS group. Conclusion Elevated lactate, high pCO2 gap, as well as decreased SvO2 at 4 hours post-operatively are the most reliable markers of LCOS after pediatric open heart surgery.
Una verdad incómoda:
Authors: Leonhard Rut , Quintana Sofía Victoria
Published: August 2021

El trabajo expone un análisis de los obstáculos epistemológicos propuestos por Bachelard (1985) y recuperados para su tratamiento pedagógico por Camilloni (1997). Estos son entendidos como teorías o creencias que se construyen en la formación y aparecen como visiones y estructuras conceptuales.

Desde allí se desprenden las categorías enunciadas por los autores de referencia para trasladarnos al campo disciplinar en tanto influyen en las prácticas docentes y en los resultados que se logran.

Escribir este texto tiene por objetivo considerar la problemática de los obstáculos epistemológicos, didácticos y/o pedagógicos, con el fin de tomar conciencia de su existencia para propiciar un cambio, a través de la búsqueda e investigación como estado permanente.
Mechanisms Underlying the Selective Therapeutic Efficacy of Carbamazepine for Attenuation of Trigeminal Nerve Injury Pain
Authors: Pineda-Farias Jorge Baruch , Loeza-Alcocer Emanuel , Nagarajan Vidhya , Gold Michael S. , Sekula Raymond F.
Published: August 2021

Different peripheral nerve injuries cause neuropathic pain through distinct mechanisms. Even the site of injury may impact underlying mechanisms, as indicated by the clinical finding that the antiseizure drug carbamazepine (CBZ) relieves pain because of compression injuries of trigeminal but not somatic nerves. We leveraged this observation in the present study hypothesizing that because CBZ blocks voltage-gated sodium channels (VGSCs), its therapeutic selectivity reflects differences between trigeminal and somatic nerves with respect to injury-induced changes in VGSCs. CBZ diminished ongoing and evoked pain behavior in rats with chronic constriction injury (CCI) to the infraorbital nerve (ION) but had minimal effect in rats with sciatic nerve CCI. This difference in behavior was associated with a selective increase in the potency of CBZ-induced inhibition of compound action potentials in the ION, an effect mirrored in human trigeminal versus somatic nerves. The increase in potency was associated with a selective increase in the efficacy of the NaV1.1 channel blocker ICA-121431 and NaV1.1 protein in the ION, but no change in NaV1.1 mRNA in trigeminal ganglia. Importantly, local ICA-121431 administration reversed ION CCI-induced hypersensitivity. Our results suggest a novel therapeutic target for the treatment of trigeminal neuropathic pain.

SIGNIFICANCE STATEMENTThis study is based on evidence of differences in pain and its treatment depending on whether the pain is above (trigeminal) or below (somatic) the neck, as well as evidence that voltage-gated sodium channels (VGSCs) may contribute to these differences. The focus of the present study was on channels underlying action potential propagation in peripheral nerves. There were differences between somatic and trigeminal nerves in VGSC subtypes underlying action potential propagation both in the absence and presence of injury. Importantly, because the local block of NaV1.1 in the trigeminal nerve reverses nerve injury-induced mechanical hypersensitivity, the selective upregulation of NaV1.1 in trigeminal nerves suggests a novel therapeutic target for the treatment of pain associated with trigeminal nerve injury.
Recent advances in solar drying system: A Review
Authors: Abdul Razak Amir , Tarminzi M A S M , Azmi M A A , Ming Y.H , Akramin MRM , Mokhtar NM
Published: August 2021

Research on solar dryer technology proliferates since it reduces the drying period while keeping nutritional values in the agricultural products. This paper presented a review of recent advances in the solar drying system. This review is composed of working principles and classifications of solar dryers. They were classified into two main elements: airflow modes, either passive or active, and the way heat is transferred: direct, indirect, mixed-mode, and hybrid. The hybrid system used several types of elements to supply additional heat in the drying system, as elaborated in this paper, such as the electrical heater, biomass, and photovoltaic system. The advantages and disadvantages of the solar dryer also being discussed in this paper
Dieta de murciélagos frugívoros y su efecto sobre la germinación de dos especies en el Área Natural Única Los Estoraques, Norte de Santander, Colombia
Authors: Anteliz Pallares Isabel Cristina , Sánchez Sánchez Angie Tatiana , Sánchez Londoño Juan David
Published: August 2021

El estudio de la dieta de los murciélagos es importante para entender cómo se conforma su ensamblaje y cómo aportan a la dinámica de los bosques. Al ser pocos los estudios de dieta de murciélagos frugívoros en el bosque seco tropical, nuestro objetivo fue describir su dieta y analizar cuál es su efecto sobre la germinación de semillas. El trabajo se realizó en el Área Natural Única Los Estoraques, Norte de Santander, Colombia; una zona de vida de bosque seco premontano (bs-PM). Para la captura de murciélagos se utilizaron redes de niebla y se recolectaron sus excretas. Las semillas de Vismia baccifera y Piper sp4, obtenidas de las excretas, fueron seleccionadas para el experimento de germinación cuya respuesta se analizó mediante el índice de capacidad de germinación. Se hizo una curva de acumulación para describir la riqueza de semillas, se calculó el índice de mejor dispersor DII y el índice de Morisita paragistro en la dieta de los murciélagos. En ninguna de las dos especies de plantas se encontraron diferenestudiar solapamiento de dieta. Se registraron diez especies de murciélagos con siete registros nuevos para un total de 18 en la zona, trece de ellas fueron frugívoras. Carollia brevicauda fue la especie más abundante y la mejor dispersora, considerándola clave para la mayoría de las especies vegetales. Seidentificaron 18 morfoespecies de semillas, incluyendo Calycolpus moritzianus, nuevo recias en la germinación de semillas obtenidas de las excretas y aquellas extraídas del fruto directamente.
Intervención fisioterapéutica en deportista con acondroplasia practicante de levantamiento de potencia adaptado y natación paralímpica. Reporte de caso
Authors: Rincón Rueda Zully Rocio , Cepeda Flórez Karen Tatiana , Fragozo Ibarra Andry Giseth , Mendoza Cardona Mildreth Rosmary , López Gómez Freddy
Published: August 2021

Introducción. La acondroplasia es una condición congénita causada por una mutación del gen codificador de crecimiento del fibroblasto que afecta la osificación endocondral y genera discapacidad estructural; además, es la causa más común de talla baja desproporcionada. Por su parte, el deporte adaptado es una disciplina deportiva que se ajusta al colectivo de personas con discapacidad y una estrategia diseñada para generar inclusión y mejorar la calidad de vida de sus participantes. Se presenta el caso de una paciente con acondroplasia a quien se le diseñó un plan fisioterapéutico de intervención enfocado a minimizar el riesgo de lesiones y prevenir la pérdida de funcionalidad como consecuencia de la práctica deportiva.
Presentación del caso. Paciente femenina de 27 años diagnosticada con acondroplasia y practicante de levantamiento de potencia adaptado y natación paralímpica, a quien mediante valoración fisioterapéutica y de la aptitud física se le encontraron alteraciones posturales y en el patrón de marcha. Dado que por su condición de base no es recomendable que practique los deportes en los cuales compite, se le diseñó un programa de entrenamiento y recomendaciones dirigido a preservar su funcionalidad y mejorar su desempeño en la práctica deportiva. El plan fue puesto en práctica y tolerado de forma adecuada por la deportista.
Conclusiones. Los planes de entrenamiento que favorezcan el mantenimiento de la condición física óptima de los participantes de deportes adaptados les permiten a estos deportistas realizar su práctica sin afectar su expectativa de vida ni su funcionalidad. El análisis del presente caso muestra cómo el fisioterapeuta desempeña un rol importante en esta población, pues los puede ayudar a disminuir las posibles complicaciones que se deriven de entrenamientos y competencias.
Caracterización geométrica de los eritrocitos nucleados de tilapia roja (Oreochromis spp)
Authors: Rodríguez Javier , Atencio Víctor , Soracipa Muñoz Ribká , Mendoza Diana , Correa Herrera Catalina , Prieto Bohórquez Signe
Published: August 2021

Introducción. En hematología, el estudio de las alteraciones de la morfología eritrocitaria contribuye con el diagnóstico de la normalidad o anormalidad de estas estructuras, sin embargo, el carácter cualitativo de los criterios diagnósticos dificulta su interpretación y alcance. Objetivo. Caracterizar los eritrocitos nucleados de tilapia roja (Oreochromis spp), en el contexto de la geometría fractal y euclidiana. Metodología. Se tomaron 50 eritrocitos nucleados de 20 extendidos de sangre de tilapia roja. Posteriormente todos los contornos del núcleo y el citoplasma de los eritrocitos fueron delineados, para superponer dos rejillas, una con el doble tamaño que la otra, para calcular mediante el método de Box Counting la dimensión fractal de cada eritrocito delineado. Adicionalmente fue calculada la superficie de estas dos partes del eritrocito. Resultados: Los resultados de este estudio revelaron que los valores de la dimensión fractal no permiten hacer comparaciones entre eritrocitos nucleados. Por su parte, la superposición de rejillas de 5x5 y 10x10 píxeles permitió observar que los valores de ocupación del citoplasma y el núcleo permiten hacer comparaciones entre los eritrocitos nucleados, junto con los valores de la superficie de estas dos partes del eritrocito nucleado. Conclusión: Los eritrocitos nucleados de tilapia roja pueden ser caracterizados mediante la medición de los valores espacios ocupados por su citoplasma y el núcleo, junto con los valores de la superficie de cada una de estas dos partes del eritrocito.
Enfermedad podal en bovinos: prevalencia y asociación con algunas variables
Authors: Arrieta L. M. , Cruz J. M. , González-Herrera L. G.
Published: August 2021

La enfermedad podal constituye uno de los síndromes más difíciles de controlar en la industria lechera. El presente estudio tuvo como objetivo cuantificar la prevalencia de enfermedad podal, evaluando su asociación con factores como raza, orden de parto y peso. Se trata de un estudio retrospectivo que utiliza los registros sanitarios y productivos de un hato lechero ubicado en el trópico alto de Colombia. Los componentes raciales presentes fueron F1 Holstein × Blanco Orejinegro, 3/4 Holstein 1/4 Blanco Orejine- gro, 5/8 Holstein 3/8 Blanco Orejinegro y Holstein 100%. Se consideraron 6 órdenes de parto. La variable enfermedad podal presenta una distribución binomial. El efecto de los factores se verificó utilizando un modelo lineal generalizado, por medio de una regresión logística (PROC GENMOD, sas versión 9.4). En caso de existir diferencias significativas, se aplicó el procedimiento LSMEANS del sas (versión 9.4) y un Odds Rattio entre los niveles que presentaron significancia. La prevalencia de enfermedad podal en el hato fue de 10,55%. Los factores de riesgo considerados fueron estadísticamente significativos: componente racial (p < 0,0009), orden parto (p < 0,0001) y peso medio de las vacas (p < 0,0001). Se observó un incremento en la prevalencia de la enfermedad asociado a la raza Holstein, orden de parto alto y bajo peso corporal. La prevalencia de enfermedad podal fue mayor en vacas Holstein puras y menor en vacas Holstein cruzadas con Blanco Orejinegro, debido a la resistencia por heterosis que la raza criolla aporta. El incremento del orden de parto al igual que el bajo peso se relacionan con una mayor prevalencia de esta enfermedad.
Associação entre níveis de ocitocina e estilos de apego numa amostra de idosos da Estratégia Saúde da Família
Authors: Nogueira Guilherme , Engroff Paula , Gotllieb Maria Gabriela Valle , Von Gunten Armin , Jardim Gabriel Behr Gomes , Neto Alfredo Cataldo
Published: August 2021

Objetivo: o objetivo desse estudo é identificar o perfil de apego de uma amostra de idosos da Estratégia Saúde da Família e verificar a associação com níveis de ocitocina no soro.Método: foi realizado um estudo transversal, descritivo e analítico com pacientes idosos, atendidos na Estratégia de Saúde da Família em Porto Alegre, RS. Foram investigadas as variáveis sociodemográficas, ocitocina e estilos de apego. Os instrumentos utilizados foram o Questionário Geral do Programa de Envelhecimento Cerebral (PENCE) para dados sociodemográficos e o Relationship Scale Questionnaire (RSQ) para estilos de apego. A ocitocina foi obtida através do soro e mensurada por meio da técnica de Enzyme-Linked Immunosorbent Assay (ELISA).Resultados: foram investigados 108 idosos, com prevalência do sexo feminino (73,1%) e média de idade de 71,8 anos. Foi observado uma correlação positiva entre ocitocina e apego seguro (p<0,05) e (r=0,195). Os resultados demonstraram, também, diferença estatisticamente significativa nos estilos de apego ansioso e medroso, entre os sexos.Conclusão: os achados deste estudo reforçam o importante papel da ocitocina como molécula moduladora do funcionamento social, reforçando a ideia de que, esse neuropeptídeo se apresenta como potencial elo entre a neurofisiologia e a formação do vínculo de apego seguro. Nossos dados sugerem, também, que o gênero pode se apresentar como aspecto influenciador na formação do apego, ampliando ainda mais a discussão acerca da neutralidade, proposta pelo modelo clássico da teoria do apego.
Identifying the central symptoms of problematic social networking sites use through network analysis
Authors: Svicher Andrea , Fioravanti Giulia , Casale Silvia
Published: August 2021

Background

Problematic social media use (PSMU) has received growing attention in the last fifteen years. Even though PSMU has been extensively studied, its internal structure is not fully understood. We used network analysis to evaluate which symptoms and associations between symptoms are most central to PSMU – as assessed by the Generalized Problematic Internet Use Scale-2 adapted for PSMU – among undergraduates.

Method

Network analysis was applied to a large gender-balanced sample of undergraduates (n = 1344 participants; M = 51.9%; mean age = 22.50 ± 2.20 years).

Results

The most central nodes in the network were the difficulty of controlling one’s own use of social media, the tendency to think obsessively about going online, the difficulties in resisting the urge to use social media and the preference for communicating with people online rather than face-to-face. This last element was strongly associated with a general preference for online social interactions and the feeling of being more comfortable online. The network was robust to stability and accuracy tests. The mean levels of symptoms and symptom centrality were not associated.

Conclusions

Deficient self-regulation and preference for online communication were the most central symptoms of PSMU, suggesting that these symptoms should be prioritized in theoretical models of PSMU and could also serve as important treatment targets for PSMU interventions.
FORMULACIÓN DE UNA HARINA INTEGRAL FUNCIONAL, A PARTIR DE CEREALES ANDINOS Y SUBPRODUCTOS DE LA UVA Y EL CAFÉ
Authors: Arias-Giraldo Sebastián , Anaya-García Sugey Elena , Muñoz Quintero Daniel , Chaux-Gutiérrez Ana María
Published: August 2021

Correspondiente con el estilo de vida del ser humano, el rubro de alimentos y bebidas debe ofrecer productos valiosos, con elevado aporte nutricional, sostenibles, de fácil preparación y con gran durabilidad; necesidad que se encuentra alineada con los Objetivos de Desarrollo Sostenible (ODS) número 2, 3 y 12, planteados por la ONU. Entre las alternativas disponibles en el mercado, sobresalen los concentrados, las harinas, las bebidas y los comprimidos. En los últimos años, se ha buscado reutilizar los residuos de diferentes sectores, aprovechando su capacidad de transformación como materia prima o insumo; las industrias del café y la uva no son ajenas a esta tendencia. Diversos estudios exponen el potencial de la cáscara del café y la uva, como fuente de compuestos fenólicos, antioxidantes y fibra dietaria. Por otra parte, la cultura gastronómica exige regresar a las raíces y a lo autóctono, en congruencia con los principios de seguridad y soberanía alimentaria. En los Andes, se dispone de la quinua y el amaranto, caracterizados por contener la totalidad de aminoácidos esenciales; además, son ricos en vitaminas E y C, y calcio, hierro y zinc. El presente proyecto de investigación busca formular un producto comestible integral, tipo harina, que conserve los beneficios ofrecidos por la cáscara de café, el epicarpio de uva, el amaranto y la quinua. Para ello, se desarrollará un estudio cuantitativo experimental, siguiendo un diseño factorial con dos fuentes de variación: tipo de cereal andino y clase de residuo. Como respuesta, se evaluará la calidad bromatológica, antioxidante, microbiológica y sensorial del alimento, con una significancia estadística de α = 0.05. Se espera obtener un alimento aceptado por el consumidor, benéfico nutricionalmente y fácil de vincular a preparaciones gastronómicas; lo anterior, con miras a su transferencia a los actores involucrados en el servicio de alimentos y bebidas.
LA ARQUITECTURA GRÁFICA COMO BASE ESTRATÉGICA COMPETITIVA EN EL DESARROLLO ECONÓMICO LOCAL DE CIUDADES DE FRONTERAS
Authors: Barrientos-Monsalve Ender José , Cáceres-Caballero José Ascensión , Alfonso-Cárdenas Javier
Published: August 2021

Las ciudades de frontera son vistas globalmente como entes territoriales en cuya esencia proyectiva basa sus estrategias en función a la cultura turística que de ellas se emane, pero su punto cardinal de interés, parte desde la arquigrafía. El propósito general de esta investigación es describir la identidad cultural desde la perspectiva de la arquigrafía, en las ciudades fronterizas a través de su propia esencia, como una estrategia competitiva del turismo en el desarrollo económico local. Para ello, la investigación se orientó bajo un enfoque cualitativo, en la modalidad documental, de revisión bibliográfica sistematizada, centrada en el método hermenéutico. En conclusión, el sentimiento de pertenencia social está dado por las teorías antropológicas desde la perspectiva de la identidad cultural. En el contexto fronterizo, los pilares del fortalecimiento económico de la población local juegan un papel importante, con la variabilidad, la adaptabilidad, la sustentabilidad y la sostenibilidad que representa la importancia de la arquigrafía. En sí misma, la promoción de la identidad cultural es, arquigráficamente hablando, una palanca económica de la competencia en su fortalecimiento, y el estímulo turístico de los mercados, que repercuten en el desarrollo local de las ciudades fronterizas, bajo el procedimiento adecuado de la identificación del tejido empresarial que se despliega desde allí.