bluuebunny/crossref_metadata_2025 huggingface dataset:
Strength Deterioration Mechanism of Bentonite Modified Loess After Wetting- Drying Cycles
Authors: Niu Ze-Lin , Xu Jian , Li Yan-Feng , Wang Ze-Feng , Wang Bao
Published: December 2021

The employment of bentonite modified loess (BML) is a common method of constructing the anti-seepage lining of landfills in the loess region of China, and its long-term secure performance is threatened by wetting-drying (W-D) cycles. Taking the remolded loess (RL) and BML with 15% in mass of bentonite as research objects, the W-D cycles test, scanning electron microscope (SEM) test and direct shear test were carried out to analyze the effects of W-D cycles on the microstructure and shear strength of samples. The regression equations between strength and micro-pore structure parameters were established by the multivariate linear stepwise regression method. The damage mechanism of BML after W-D cycles was studied by establishing damage degree models based on pore area ratio and cohesion. Results indicate that the water absorption and expansion of bentonite effectively block the intergranular pores, resulting in more medium and small pores and more pronounced surface contact of particles. After W-D cycles, the particle arrangement of samples before and after bentonite modification tends to be loose. Both the pore area ratio and fractal dimension increase and tend to stabilize after five cycles. The BML exhibits lower pore area ratio and greater fractal dimension while its cohesion and internal friction angle show more significant decrease after W-D cycles than those of RL. The damage variables based on pore area ratio and cohesion well describe the W-D induced damage of loess before and after modification from macro- and micro-scale perspectives. The damage degree of samples increases with W-D cycles, but the increment decreases.
GRU-BWFA Classifier for Detecting DDoS Attack within SNMP-MIB Dataset
Authors: Rajasekar P , Magudeeswaran V.
Published: December 2021

With the advancing trends in the field of information technology, the data users were subjected to face differernt of attacks. Hence effective and prompt detection of malicious attacks must be optimized in terms of confidentiality, privacy, availability and integrity. Accordingly this research paper provides an effective mechanism for detecting and classifying DDoS attacks such as TCP-SYN, UDP flood, ICMP echo, HTTP flood, Slowloris Slow Post and Brute Force attack, by utilizing machine learning methods within SNMP-MIB dataset. MIB (Management Information Base) is meant for attack classification database linked to the SNMP (Simple Network Management protocol). Three classifiers are considered such as MLP, Random forest, Adaboost to construct the detection model. Significantly, Gated Recurrent Unit Neural Network based on Bidirectional Weighted Feature Averaging (GRU-BWFA) classifier is utilizing as a proposed classifier for high detection rate and accuracy in distinguishing the mentioned DDoS attacks. Feature selection is performed using the Enhanced Salp Swarm Optimization technique to select the optimal features for identify the attacks. The application of various classifier provides a detailed study on the effectiveness of SNMP-MIB dataset in detecting DDoS attacks. Empirical findings indicate that machine learning methods are highly effective at detecting and classifying the attacks with a higher accuracy rate.
Visual Evaluation of Regional Tourism Attractiveness Based On Transportation: a GIS Quantitative Analysis Method
Authors: Qin Xiaochun , Meng Fantong , Meitner Michael , Ni Anchen
Published: December 2021

The research in evaluating regional transportation tourism attractiveness has mainly based on qualitative or semi-quantitative analysis, and it has not been achieved quantitative and visual evaluation. The quantitative evaluation method of regional tourism attractiveness was established by employing the analytic hierarchy process and Delphi method in this paper. Moreover, the evaluation of tourism attractiveness was divided into four factors: natural condition index, tourism condition index, transportation condition index, and social economy index. The index weight was obtained by the judgment matrixes, and the weighted overlay analysis method using ArcGIS was adapted to study the coordinated development of tourism transportation. The results show that it was scientific and feasible to make a quantitative and visual tourism attractiveness evaluation based on the four aspects of natural condition, tourism condition, transportation condition, and social economy through the verification of a case study of the Great Jiuzhai Ring Tourist Area. The research revealed that the transportation system and the tourism system interacted with each other and had an excellent positive feedback mechanism, which could further promote the integrated development of transportation and tourism, and play theoretical and methodological guiding significance on regional tourism transportation network planning based on tourism resources.
Primary Care Disease Management for Venous Leg Ulceration – Study Protocol for the Ulcus Cruris Care [UCC] Randomized Controlled Trial (DRKS00026126)
Authors: Senft Jonas D , Fleischhauer Thomas , Frasch Jona , Rees Wiebke van , Feisst Manuel , Schwill Simon , Fink Christine , Poss-Doering Regina , Wensing Michel , Mueller-Buehl Uwe , Szecsenyi Joachim
Published: December 2021

Background
Venous leg ulcers (VLU) have a prevalence of 1–2% in developed countries and affected patients are severely and long-term impaired in daily activities, work and social participation. Evidence-based outpatient treatment based on compression therapy is frequently not implemented. The “Ulcus Cruris Care” project was established to develop a disease management concept to improve outpatient treatment for patients with VLU in German primary care. For this purpose, a multifaceted intervention was conceived consisting of an online training for general practitioners and medical assistants, standardized treatment recommendations, e-learning and print-based information for patients, and a software support for case-management. Main aims of the Ulcus Cruris Care intervention are to promote standardized treatment according to current scientific knowledge, to facilitate case management for VLU patients exerted by medical assistants and to support patient education and participation in the treatment process. The UCC trial was designed to evaluate the effectiveness of the Ulcus Cruris Care intervention.
Methods
The UCC trial is a prospective cluster-randomized controlled multicenter trial. Fifty GP practices are intended to be recruited and randomized 1:1 to intervention or control arm. Patients with venous leg ulcers will be recruited by participating GP practices, to include a total of 63 patients in each arm. The primary outcome is time to ulcer healing. Secondary outcomes comprise number and sizes of ulcers, recurrence, pain intensity according to the Visual Analogue Scale, health-related quality of life according to EQ-5D-5L, depressiveness according to Patient Health Questionnaire (PHQ-9), patient satisfaction according to the Patient Assessment of Chronic Illness Care (PACIC-5A) query and adherence to VLU treatment. The outcome analysis of the UCC trial is accompanied by a health economic analysis and a process evaluation.
Discussion
The UCC trial will evaluate whether the Ulcus Cruris Care intervention may lead to faster wound healing, higher health-related quality of life and lower use of medical resources. If the intervention turns out to have a positive impact on assessed outcomes, comprehensive implementation in primary care may be considered.
Trial registration
The trial protocol (version 1 as of July 19th, 2021) has been registered in the German Clinical Trials Register on August 30th, 2021 (DRKS000261265).
Molecular Delineation of De Novo Small Supernumerary Marker Chromosomes in Prenatal Diagnosis, A Retrospective Study
Authors: Hu Shuang , Kong Xiangdong
Published: December 2021

Background To define the genotype-phenotype correlation of small supernumerary marker chromosomes (sSMCs) and conduct precise genetic counseling, we retrospectively searched and reviewed de novo sSMC cases detected during prenatal diagnosis at The First Affiliated Hospital of Zhengzhou University. Chromosome karyotypes of 20,314 cases of amniotic fluid from pregnant women were performed. For 16 samples with de novo sSMCs, 10 were subjected to single-nucleotide polymorphism (SNP) array or low-coverage massively parallel copy number variation sequencing (CNV-seq) analysis. Results Among the 10 sSMC cases, two sSMCs derived from chromosome 9, and three sSMCs derived from chromosomes 12, 18 and 22. The remaining 5 cases were not identified by SNP array or CNV-seq because they lacked euchromatin or had a low proportion of mosaicism. Four of them with a karyotype of 47,XN,+mar presented normal molecular cytogenetic results (seq[hg19] 46,XN), and the remaining patient with a karyotype of 46,XN,+mar presented with Turner syndrome (seq[hg19] 45,X). Five sSMC samples were mosaics of all 16 cases. Conclusion Considering the variable origins of sSMCs, further genetic testing of sSMCs should be performed by SNP array or CNV-seq. Detailed molecular characterization would allow precise genetic counseling for prenatal diagnosis.
The Comparison of Breast Cancer in Southern China and America: a Multicentre Study in China Versus SEER Database
Authors: Niu Yingjie , Zhang Fan , Chen Dong , Ye Guolin , Li Yong , Zha Yong , Chen Wenlin , Liu Dequan , Liao Xiaoming , Huang Qinghua , Tang Wei , Cai Gengxi , Guo Rong , Li Hongyang , Tang Shicong
Published: December 2021

Background and Objective: There are different characteristics of BC in developing countries and developed countries. We intend to study the factors which influence the survival and prognosis of BC between southern China and the United States. Methods: To study the two groups BC patients in southern China from 2001 to 2016 and SEER database from 1975 to 2016. To register, collect and analyze the clinicopathological features and treatment information. Results: Our study found that there are significant differences in tumor size, positive lymph node status and KI-67 between southern China and SEER cohort (P<0.000). Conclusions: The age, tumor size, positive-node and KI-67 may cause the difference of morbidity and mortality of BC patients in southern China and SEER cohort.
Assessment of Hydration Process And Mechanical Properties of Cemented Paste Backfill By Rebound Method
Authors: Huang Sa , Wang Yongyan , Yu Zhuoqun , Du Peng , Liang Zhonghao
Published: December 2021

Backfilling mining method is a green mining method which is being used widely, nevertheless, the uniaxial compressive strength (UCS) of the cement backfill paste (CPB) on site is difficult to measure, and it is impossible to know the internal cementation, for this reason, the rebound method is improved and introduced in this paper. Standard specimens of CPB were made and cured for different curing age under standard curing conditions. The hardness test of each part of the CPB is completed, the unconfined compression test is carried out, and the functional model of the hardness of each part of the CPB is established, which was a function of radius and age. Based on the nonuniformity of the filling material, the failure mode of CPB is analyzed and verified in the test. The results show that the exponential function model is more suitable for the relationship between the external hardness and the overall strength, and this conclusion is of great significance in construction site. In addition, the corresponding relationship between hardness and local strength was calculated and verified, the results show that the simple model can predict the variation of local strength with hardness better, and the quadratic function model is the best choice.
Does Marriage Require Knowledge? Experiences of Women Participating in Pre-Marriage Education
Authors: Kusuma Wijaya Susan Octavianna , Ninin Retno Hanggarani , Abidin Fitri Ariyanti
Published: December 2021

Today the phenomenon of getting married at a young age is rising and shown through social media. According to Islamic religious rules, there are many pros and contras against this phenomenon, especially related to marriage. It has led to various pre-marriage educational programs as a means of understanding and preparing for marriage. This study aimed to explore the experiences of a single woman in emerging adulthood who participates in Pre-Marriage Talk Class. This study used a qualitative approach with the snowball sampling technique. A total of 5 respondents participated in this study, and data were collected through an online interview. The respondent’s answers were then analyzed thematically. The results showed that Pre-Marriage Talk Class provides additional knowledge, awareness, and mindset to participants, including 1) knowledge about the age of marriage; 2) knowledge about the vision and mission of getting married; 3) awareness of knowing the self; 4) knowledge of managing the self and environment, and 5) changing mindset. From the results, we can conclude that Pre-Marriage Talk Class is a suitable program for emerging adults who want to gain knowledge and skills related to themselves, how to manage self and environment, as well as an overview of the dynamics of married life that can be anticipated
PEMENUHAN HAK-HAK PENDIDIKAN ANAK PADA MASA PANDEMI COVID-19 PERSPEKTIF UNDANG-UNDANG PERLINDUNGAN ANAK
Authors: Sholihah Hani
Published: December 2021

Abstrak: Memperoleh pendidikan merupakan salah satu hak anak. Pada masa pandemi Covid-19, proses pembelajaran di sekolah dilakukan secara daring (online). Dalam proses ini, terjadi beberapa kasus kekerasan terhadap anak. Oleh karena itu, penelitian ini bertujuan untuk mengetahui bagaimana pemenuhan hak-hak pendidikan anak dan bagaimana perlindungan anak dari tindak kekerasan pada masa pandemi Covid-19 dalam perspektif Undang-Undang Nomor 23 Tahun 2002 tentang Perlindungan Anak, khususnya pasal 50 dan 54. Metode yang digunakan dalam penelitian ini adalah  metode deskriptif dengan pendekatan kuantitatif. Pengumpulan data dilakukan dengan cara penyebaran angket melalui google form, yang disebarkan via whatsapp. Subjek yang digunakan pada penelitian ini adalah orang tua siswa Sekolah Dasar/Madrasah Ibtidaiyah Kota dan Kabupaten Tasikmalaya dengan mengambil 227 responden. Hasil penelitian menunjukkan bahwa pemenuhan hak-hak anak dalam bidang pendidikan pada masa pandemi Covid-19, pada jenjang pendidikan SD/MI di Kota dan Kabupaten Tasikmalaya, sangat baik dengan perolehan nilai rata-rata yang termasuk kategori sangat tinggi. Namun, perlindungan anak dari tindakan kekerasan, baik fisik maupun psikis, belum sepenuhnya terpenuhi. Meskipun dengan jumlah kasus yang tidak terkategori tinggi, tindakan kekerasan terhadap anak dalam bentuk apapun, merupakan sesuatu yang tidak dibenarkan dan harus dicegah.

  

Abstract: Obtaining education is one of the rights of children. During the Covid-19 pandemic, the learning process in schools was carried out online. In this process, several cases of violence against children occurred. Therefore, this study aims to find out how to fulfill children's education rights and how to protect children from violence during the Covid-19 pandemic in the perspective of Law Number 23 of 2002 concerning Child Protection, particularly articles 50 and 54. The method used is used in this research is a descriptive method with a quantitative approach. Data collection was carried out by distributing questionnaires via a google form, which was distributed via WhatsApp. The subjects used in this study were the parents of students of the Elementary School / Madrasah Ibtidaiyah Kota and Tasikmalaya Regency by taking 227 respondents. The results showed that the fulfillment of children's rights in the education sector during the Covid-19 pandemic, at the SD / MI education level in the City and District of Tasikmalaya, was very good with the acquisition of an average score which was in the very high category. However, child protection from acts of violence, both physical and psychological, has not been fully fulfilled. Even with the number of cases that are not categorized as high, acts of violence against children in any form are something that is not justified and must be prevented.
Travelling narratives and images in times of migration
Authors: Åsebø Sigrun , Gjesdal Anje Müller , Skalle Camilla
Published: December 2021

Migrant narratives and aesthetic practices influenced by experiences of exile and migration constitute a growing field in contemporary art and literature. Current trends in migration and globalisation have lead to an increase in travelling narratives, images and objects, and the production of aesthetic practices describing and problematising exile and migration, working in and through tradition. Migratory patterns and issues related to the protection of refugees and asylum seekers contribute to the strong societal impact of migrant aesthetics and narratives, but they also serve to explain the need for them as such, and the need to reexamine them. More than ever, we need to understand the experiences of exiles, migrants and refugees. The objective of this special issue is therefore to examine textual, material and visual expressions that represent, discuss and problematise migration.
Art and contemporary Irish emigrants: Aesthetics and networks of affect in David Monahan’s ‘Leaving Dublin’
Authors: Williams Rachel L.
Published: December 2021

Photographer David Monahan’s Leaving Dublin serves as a lens for examining the roles played by networks of affect and aesthetics in the contemporary Irish experience of migration. This article explores the series from the perspective of Actor-Network Theory. I will consider how the Internet has changed both experiences of migration and the creation and distribution of art by altering networks of affect. I will also discuss the role contemporary art plays in these networks, serving as a nexus between personal and public experiences of migration.
‘White queens’ and ‘Nubian fiends’: Early Italian American fiction and the problem of colonialism
Authors: Ciribuco Andrea
Published: December 2021

This article analyses the transatlantic influence of colonialist discourse regarding Italian colonial wars in East Africa, by focusing on literary texts. In the emerging Italian American literature, two works by key authors reflected on the impact of colonialist propaganda in the Italian America. Emanuel Carnevali’s ‘Tale One’ (1919) centers on his aunt’s experience in Eritrea around the time of the battle of Adwa (1896). The analysis of these two texts, which rewrote and challenged the central elements of nationalist propaganda, offers a unique chance to understand the complex relationship between nationalist discourse and diasporic communities, in a textual form—migrant literature—that by definition re-uses and combines elements from different cultural spaces to make sense of the experience of displacement.
Stitching the cloths of serial migrant life: The quilts of Barbara James
Authors: Ossman Susan
Published: December 2021

In this article, I study the quilting practice of Barbara James to investigate the making of serial migrant subjects. Serial migrants are not from a single place, nor do they travel in the same direction. They have moved beyond a first experience of immigration and in so doing, step beyond the home/host dualities of immigration. One might see the project of following their paths as a move from accounts of the creative, imaginative ‘third space’ produced by immigrants’ arrival in their new homes, toward a consideration of the concrete ‘third place’ of the second or third-time immigrant. Exile, economic migrant, love migrant, exchange student, refugee: a serial migrant adds up not just several identities but systems of categorisation over time. This migratory subject often changes ‘positions’ not only geographically but socially, making us question the static assumptions of social theory with their experiences of diverse approaches to nationality, class, race, ethnicity and gender.
Travelling toponymy: The contribution of place names to the textual representation of place and memory in Abdellah Taïa’s Une mélancolie Arabe
Authors: Gjesdal Anje Müller
Published: December 2021

Narratives of exile and migration pose important questions related to the role of language in the representation of space, both that of home and away as well as sites of transit. This article argues that the textualisation of space is a central strategy for representing these spaces as place, i.e. as the site and product of lived experience, and that toponyms, place names are an important linguistic tool in this respect. The article draws on critical place name studies in order to examine the political and emotional aspects of place names in narratives of exile and migration. To do so, it examines the role of place names in Abdellah Taïa’s novel Une mélancolie Arabe, a text where place names play an important role, as the protagonist navigates between his native Morocco, his adopted city Paris, and Cairo, capital of the Arab world; and where the names of the cities come to function as symbolic representations of home and freedom. The use of place names thus becomes a means of recreating places that may be geographically distant, but emotionally close. Moreover, the close relations the text establishes between place names on the one hand, and emotions and affect on the other, give reason to reconsider the textual and mnemonic functions of place names.
Bordering: Creating, contesting and resisting practice
Authors: Klein Elise , Kothari Uma
Published: December 2021

Materially and symbolically manifest, borders are shaped by history, politics and power. This first special issue of a two-part series brings together an international collective of authors who presented their papers at a conference on Technologies of Bordering convened by the editors at the University of Melbourne, Australia in July 2019. We invited presentations that critically engage with multiple and varied forms of bordering as expressions of power and oppression, as well as those that considered the possibilities and aspirations for more hopeful and progressive futures. Articles explored a range of issues from borders within and beyond detention centres and carceral systems to colonial and postcolonial forms of bordering. Drawing on a variety of empirical research across different spaces and scales, a range of theoretical perspectives and a diversity of methodological approaches, the articles collectively address the material, digital, virtual and human technologies that divide, exclude, contain, control and govern humans and non-humans.
Transgressing borders with participatory video technologies: Reflections on creative knowledge production with asylum seekers in Australia
Authors: Lobo Michele , Barry Kaya
Published: December 2021

In this article we ask: how might the significant turn towards creative modes of knowledge production bring together researchers, participants and audiences to disrupt bordering technologies that dehumanise asylum seekers? We focus on videos taken by asylum seekers in Darwin who express their everyday experiences of encountering and transgressing borders. As researchers, we use experimental editing techniques to make these transgressions visible in a society with a white majority culture. We argue, however, that these video techniques often work to privilege our creative agency as researchers, even though the aim is to illuminate different temporalities and visualities of the global refugee crisis. This article problematises this agency and attends to ethical dilemmas by revisiting the juxtapositions, montages, fades, distortions and vortexes we use to centre asylum seeker lives. These visual techniques are an attempt to respond to xenophobic nationalism and racially discriminatory immigration policies through forms of digital activism that transgress standard ‘borders’ of representation and the self/other borders of public debates. In our demand for social and cultural justice, we are inspired by work that uses the affordances of digital technologies to dismantle the rigidity of sovereign borders.
Bordering: Creating, contesting and resisting practice
Authors: Klein Elise , Kothari Uma
Published: December 2021

Materially and symbolically manifest, borders are shaped by history, politics and power. This second special issue of a two-part series brings together an international collective of authors who presented their papers at a conference on Technologies of Bordering convened by the editors at the University of Melbourne, Australia in July 2019. We invited presentations that critically engage with multiple and varied forms of bordering as expressions of power and oppression, as well as those that considered the possibilities and aspirations for more hopeful and progressive futures. Articles explored a range of issues from borders within and beyond detention centres and carceral systems to colonial and postcolonial forms of bordering. Drawing on a variety of empirical research across different spaces and scales, a range of theoretical perspectives and a diversity of methodological approaches, the articles collectively address the material, digital, virtual and human technologies that divide, exclude, contain, control and govern humans and non-humans.
Between the land and the sea: Refugee experiences of the lighthouse as a real and symbolic border
Authors: Kothari Uma
Published: December 2021

In the context of the refugee crisis, seascapes are taking on new dimensions with borders shifting from the shoreline to being redrawn in the water itself. As such, refugees are now crossing waters that have become extended sovereign borders. This is manifest in increased maritime surveillance to prevent refugees arriving by boat and landing on Europe’s and Australia’s shores. In this context, materially and symbolically, lighthouses mark out the space between the sea and land and in so doing, delimit these territorial and maritime borders. Although the function of the lighthouse is to warn those at sea of the dangers on the coastline, steering them away from coastal hazards and guiding them through a safe passage, for many sea travellers it can also represent the safety of the land, of arrival. This article explores the ambiguous roles and effects of lighthouses; uniquely placed as sentinel posts along the coast they can aid military surveillance and control while at the same time enabling humanitarian assistance. It explores these conflicting functions focusing on how the lighthouse, as a border between land and sea, simultaneously protects and excludes offering beacons of hope as well as signalling danger. The article draws on the arrival of refugees at Korakas lighthouse on the Greek island of Lesvos to illuminate these variable functions.
Westphalian sovereignty as a zombie category in Australia
Authors: Everuss Louis
Published: December 2021

State sovereignty is customarily connected to the 1648 Peace of Westphalia, which it is argued established the ideal of political authority being tied to static geographical containers. While academic scholarship has demonstrated that this ideal fails to account for performative and fluid modes of political power, Westphalian sovereignty remains an influential feature of political discourse. This article argues that Westphalian sovereignty consequently fits Ulrich Beck’s description of a ‘zombie category’, a dead social institution kept alive in political and public discussion. This is demonstrated in the context of the Australian State’s exclusion of Aboriginal and Torres Strait Islander peoples, as well as asylum seekers arriving by boat. Drawing on Giorgio Agamben’s theories of sovereignty, I contend that these populations are excluded from the Australian polity because of how they move, while other subjects including ‘genuine refugees’ and European settlers are included due to their ideal (im)mobilities. I argue that this underlying mobile logic of Australian sovereignty and exclusion is hidden by the zombie notion of a static Australian state, which delegitimatizes humanitarian and indigenous claims to sovereignty based on experiences of forced mobility and mobile expressions of political authority.
Biological Mechanisms of Sustaining Deep Molecular Response in Chronic Myeloid Leukemia Upon Withdrawal of Tyrosine Kinase Inhibitors
Authors: Chelysheva Ekaterina Yurevna , Guryanova M.A. , Turkina A.G.
Published: December 2021

The feasibility of treatment-free follow-up in chronic myeloid leukemia (CML) patients is an important issue in the era of tyrosine kinase inhibitors (TKI). The clinical trials of TKI withdrawal in case of a stable deep molecular response prove the probability of sustaining molecular remission in 40-60 % of patients. Treatment-free remission (TFR), even under persistence of residual leukemia cells, suggests that there are special biologically determined mechanisms of tumor cell proliferation control, which are independent of BCR-ABL kinase activity. The search for factors determining differences in residual leukemia clone kinetics upon TKI withdrawal is an objective which is crucial for understanding TFR as a new biological phenomenon. The review provides worldwide evidence dealing with the study of immunological, genetic, and other biological mechanisms underlying the control of minimal residual disease upon TKI discontinuation in CML patients.
Prediction of Treatment Efficacy in Relapsed Chronic Lymphocytic Leukemia
Authors: Kalashnikova Olga Borisovna , Moiseev I.S. , Gindina T.L. , Izmailova E.A. , Ivanova M.O. , Kondakova E.V. , Mikhailova N.B. , Kulagin A.D.
Published: December 2021

Background. The emergence of signaling pathway inhibitors (SPI) considerably improved the prognosis in relapsed chronic lymphocytic leukemia (R-CLL). Nevertheless, some patients cannot achieve optimal and sustained response. TP53 gene defects determine the refractoriness to immunochemotherapy (ICT) and lower rates of progression-free survival on SPI therapy. However, the prognostic value of complex karyotype (CK) in CLL has long been disputed. In recent years, greater attention has been placed on the prognostic impact of CK in the context of SPI therapy. Materials & Methods. The study included 180 patients who received the drug treatment for R-CLL (113 of them with ICT, 67 of them with SPI). Their age at the onset of second-line therapy, the response to first-line therapy, early (< 24 months) progression after first-line therapy, the number of therapy lines, and the presence of CK and TP53 gene defect were regarded as prognostic markers. Taking into account the clonal evolution in CLL, to assess the significance degree of the above predictors, Cox proportional hazards regression model with time-dependent variables was used. Results. The following independent factors proved to significantly reduce the risk of death: response achieved immediately after first-line therapy (hazard ratio [HR] 0.38; 95% confidence interval [95% CI] 0.20-0.72; p = 0.003) and the number of therapy lines (HR 0.56; 95% CI 0.37-0.86; p = 0.008). Treatment with only ICT in first and subsequent lines was associated with increasing risk of death (HR 2.25; 95% CI 1.09-4.63; p = 0.028). Genetic risks worsened the prognosis to a high degree of significance in the case of TP53 gene defect with excluded or unknown CK status (HR 10.54; 95% CI 4.25-26.17; p < 0.001) as well as in the case of CK (HR 14.08; 95% CI 5.77-34.35; p < 0.001). A significant predictor of poor outcome was reported to be the factor of unknown CK status without TP53 gene defect (HR 4.15; 95% CI 1.72-10.00; p = 0.002). Neither relapse time after first-line therapy nor the age > 65 years showed independent prognostic value. Conclusion. Standard karyotyping of peripheral lymphocytes with specific stimulation establishes a clearer disease prognosis and suggests the optimal choice of R-CLL treatment strategy.
Service Level Management of Information Technology and System in ITB STIKOM Bali
Authors: Dewi Nyoman Ayu Nila , Prasatria A. A. Ngurah Bima
Published: December 2021

ITB STIKOM Bali is a technology-based university so that all business processes, especially related to academics, student affairs, and finance, utilize information technology. Management of the information system and technology is carried out by the Computer and Network Center unit (Pusat Komputer dan Jaringan - PUSKOMJAR). In the management of Information Technology (IT) services, an agreement is needed in the form of Service Level Management (SLM) which contains the level of service, quality of service, and complaints handling, so users’ needs are aligned with the system developer. Meanwhile, in managing the internal system of ITB STIKOM Bali, the agreement between PUSKOMJAR and related units is only in the form of submitting a form for making or changing the system. Therefore, it raises a problem if there is a mismatch in the manufacture or development of the system because there is no contract document that regulates in detail about the system. Hence, designing an SLM of IT and system services at ITB STIKOM Bali to overcome these problems is necessary. The research presents a case study by analyzing and designing the SLM of service system and IT in ITB STIKOM Bali. The applied research method is literature study and observation, analysis of existing SLM, designing new SLM, and conclusions. The result of the research is a document of SLM for internal IT and system services at ITB STIKOM Bali. Based on the analysis and design of SLM, the SLM document can help the PUSKOMJAR in documenting IT service information and making it easier for users to get information related to the provided IT services.
Photocatalysis and flocculation processes for recycling aquaculture effluent into nutrient-rich irrigation water
Authors: Al Juboury Maad F. , Abdulredha Muhammad , Nile Basim K.
Published: December 2021

This research aimed to create a novel technique for recovering fertilizers from aquaculture effluent to overcome potential non-renewable fertilizers shortages. There are two steps: a photocatalyst technique for nutrient mobilization, succeeded by solids precipitating with two natural and one synthetic flocculants. The photocatalytic degradation of organonitrogen compounds in batch experiments started under the irradiation of sunlight. Following that, photocatalytic breakdown of organonitrogen compounds produces inorganic nitrogen constituents like NH4+, NO2−, and NO3−, which could be used as manure. It was found that, after 12 h of circulation, the concentration of inorganic nitrogen became NH4+ = 17.2 g/L, NO2− = 18.1 mg/L, and NO3− = 15.9 mg/L. The jar test was adopted to assess the capacity of two natural compounds (tamarind kernel polysaccharide (TKP) and tannin-based substance (TBS)) and synthetic water-soluble polymer cationic polyacrylamide (SWP) to reduce turbidity, total suspended solids (TSS), chemical oxygen demand (COD) and colour. The findings revealed that with a dose of 20 mg/L of TBS, 20 mg/L of TKP, and 50 mg/L of SWP, the maximum turbidity reductions were 95, 93, and 94%, respectively. The TBS was slightly better than TKP and much better than SWP in terms of coagulation activities with TSS, COD and colour maximum removal efficiencies.
Hydrological time series prediction by extreme learning machine and sparrow search algorithm
Authors: Feng Bao-fei , Xu Yin-shan , Zhang Tao , Zhang Xiao
Published: December 2021

In general, accurate hydrological time series prediction information is of great significance for the rational planning and management of water resource systems. Extreme learning machine (ELM) is an effective tool proposed for the single-layer feedforward neural network in regression and classification problems. However, the standard ELM model falls into a local minimum with a high probability in hydrological prediction problems since the randomly assigned parameters (like input-hidden weights and hidden biases) often remain unchanged in the learning process. For effectively improving the prediction accuracy, this paper develops a hybrid hydrological forecasting model where the emerging sparrow search algorithm (SSA) is firstly used to determine the satisfying parameter combinations of the ELM model, and then the Moore–Penrose generalized inverse method is chosen to analytically obtain the weight matrix between the hidden layer and output layer. The proposed method is used to forecast the long-term daily runoff series collected from three real-world hydrological stations in China. Based on several performance evaluation indexes, the results show that the proposed method outperforms several ELM variants optimized by other evolutionary algorithms in both training and testing phases. Hence, an effective evolutionary machine-learning tool is developed for accurate hydrological time series forecasting.
Identification of higher education administration applications efforts to improve digital-based academic services
Authors: Dacholfany Muhammad Ihsan , Noor Triana Rosalina , Diana Eka , Nurzen. S M. , Prayoga Diansanto
Published: December 2021

The authors believe that the presence of technology, especially digital applications, has not only made it easier for the work of a limited group such as business and banking and other businesses, but this digital application has also provided extraordinary convenience to educational administration matters especially universities. We have collected evidence of researchers' findings in technology effectiveness in administrative services at universities. Furthermore, this information requires a comprehensive study to summarize the data as a discussion material to identify how the ease of providing high-quality applications can be improved with digital technology application services. In this field, we use a coding application form for a comprehensive data evaluation and conclude that the data findings are significant in answering the problem on the principle of high validity. Based on this, we can understand that technology has revolutionized administrative services at universities, including managing student literacy both from study entry and graduation, it is also helpful for academic services, financial affairs, academic development management. We believe this data is in answering problems and the existence of these findings is an essential input for efforts to develop the application studies using applications to improve the quality of high change services in the future.
The role of interactive teaching methods in the formation of students' professional competence
Authors: Nikolaevna Kalinina Olga , Dolievna Shakarova Feruza , Isanbayevna Yadgarova Guzal
Published: December 2021

This article is devoted to the topical topic of the application of interactive methods. Interactive teaching methods provide the solution to educational problems in various aspects. The interest in interactive methods is caused by the need to improve the modern system. The possession of interactive learning technology and its use in the educational process, including in Russian language lessons, will undoubtedly contribute to the development of students ' qualities that correspond to the processes taking place in life today. The paper also presents the technologies of conducting Russian language lessons using interactive methods and their significance.
Pragmalinguistic aspects of compound nouns in English and Uzbek
Authors: Yuldasheva Nargiza Ergashbayevna , Yusupova Sanobar Tursunboyevna , Bakhtiyarov Mukhtorjon Yakubovich , Abdujabborova Malika Abduvaitovna , Abdurashidova Nilufar Abdurashidovna
Published: December 2021

This article describes compound nouns in English and Uzbek, their specific pragmatic aspects. Although the problem of compound nouns in linguistics has been studied by many linguists, there are many unsolved problems in comparing compound words in languages ??and analyzing them from a pragmalinguistic point of view. The compound word, which has a special place in the richness of language vocabulary, is in fact a convenient way of naming in simple terms the concepts of events that take place in reality, of existing objects. Hence, it can be concluded that the study of semantic, grammatical and syntactic features of language alone is not enough. As a result, the field of "pragmatics" has found its place in linguistics, having its own goals and objectives. In addition, the article also uses analysis from examples from the literature to reveal the pragmatic nature of compound words. However, scientific examples have shown that no sign is a leading factor in determining the nature of compound words.
Tact maxims in asking questions in English teaching learning process
Authors: Napitupulu Fenty Debora , Sianturi Sri Sofian , Sipayung Kammer , Tampubolon Sahlan
Published: December 2021

Objectives: This paper aims to describe the forms of tact maxims of asking questions in the English teaching-learning process. Methods: This paper applied qualitative research, where the data collection was observation. Result: There are twenty-four forms of tact maxims of asking questions in the English teaching-learning process. Conclusion: the tact maxim with politeness rules is in the polite category. Speakers ask questions using question words without threatening the face of the hearer.
Feed protein utilization and nitrogen emission of young and mature Kejobong goats fed different ratios of concentrate and forage
Authors: Nabila Farah , Restitrisnani Vita , Adiwinarti Retno , Purnomoadi Agung
Published: December 2021

This study aimed to evaluate feed protein utilization and nitrogen emission of young and mature Kejobong goats fed different concentrations of concentrate and forage. Sixteen heads of male Kejobong goats consisted of eight heads young goats (5 months old) and eight heads mature goats (9 months old) with initial body weight (BW) of 14 ± 1.46 kg, and 22.3 ± 1.99 kg, respectively were arranged in a nested design. All goats were fed with two different rations of concentrate and forage (C30 = 30% concentrate: 70% forage and C70 = 70% concentrate: 30% forage). The data were analyzed using ANOVA procedure. This study showed that the average daily gain (ADG) did not differ (p>0.05) in both ages, but it differed (p<0.05) in concentrate levels. The ADG of goats fed C70 was significantly higher (p<0.05) than those of goats fed C30 in both ages. The digestible crude protein (DCP) of young and mature goats was similar (p>0.05), while there was a significantly difference (p<0.05) between the treatments. There were no effects of different ages of goats and concentrate levels on feed conversion ratio (FCR) (p>0.05). The different ages of goats and concentrate levels affected N retention (g/day) and total N2O emission (g/day). It was concluded that ADG, DCP and FCR did not differ in mature and young Kejobong goats, while young goats had less N2O emissions than mature goats. Goats fed 70% of concentrate improved their ADG, DCP, N retention (g/day) and produced less N2O emission.
Prediction Algorithms for Blood Pressure Based on Pulse Wave Velocity Using Health Checkup Data in Healthy Korean Men: Algorithm Development and Validation
Authors: Park Dohyun , Cho Soo Jin , Kim Kyunga , Woo Hyunki , Kim Jee Eun , Lee Jin-Young , Koh Janghyun , Lee JeanHyoung , Choi Jong Soo , Chang Dong Kyung , Choi Yoon-Ho , Chung Ji In , Cha Won Chul , Jeong Ok Soon , Jekal Se Yong , Kang Mira
Published: December 2021

Background

Pulse transit time and pulse wave velocity (PWV) are related to blood pressure (BP), and there were continuous attempts to use these to predict BP through wearable devices. However, previous studies were conducted on a small scale and could not confirm the relative importance of each variable in predicting BP.

Objective

This study aims to predict systolic blood pressure and diastolic blood pressure based on PWV and to evaluate the relative importance of each clinical variable used in BP prediction models.

Methods

This study was conducted on 1362 healthy men older than 18 years who visited the Samsung Medical Center. The systolic blood pressure and diastolic blood pressure were estimated using the multiple linear regression method. Models were divided into two groups based on age: younger than 60 years and 60 years or older; 200 seeds were repeated in consideration of partition bias. Mean of error, absolute error, and root mean square error were used as performance metrics.

Results

The model divided into two age groups (younger than 60 years and 60 years and older) performed better than the model without division. The performance difference between the model using only three variables (PWV, BMI, age) and the model using 17 variables was not significant. Our final model using PWV, BMI, and age met the criteria presented by the American Association for the Advancement of Medical Instrumentation. The prediction errors were within the range of about 9 to 12 mmHg that can occur with a gold standard mercury sphygmomanometer.

Conclusions

Dividing age based on the age of 60 years showed better BP prediction performance, and it could show good performance even if only PWV, BMI, and age variables were included. Our final model with the minimal number of variables (PWB, BMI, age) would be efficient and feasible for predicting BP.
The Use of Telemedicine in Cancer Clinical Trials: Connect-Patient-to-Doctor Prospective Study
Authors: Meghiref Yasmine , Parnot Charles , Duverger Claire , Difoum Françoise Lilly , Gourden Audrey , Yssaad Halima , Leiterer Caroline , Bedekovic Caroline , Blanchard Julien , Nait Ammar Houria , Schernberg Antoine , Vanquaethem Hélène , Helissey Carole
Published: December 2021

Background

Telemedicine is currently being adopted for the management of patients in routine care. However, its use remains limited in the context of clinical trials.

Objective

This study aimed to demonstrate the feasibility of telemonitoring and patient-reported outcomes collection in the context of clinical trials.

Methods

The patients who were included in an interventional oncology clinical trial were eligible. The patients were registered with a digital tool to respond to a patient-reported outcomes questionnaire (ePRO) based on CTCAE (The Common Terminology Criteria for Adverse Events, National Cancer Institute), version 5.0, personalized to their pathology and treatment. An algorithm evaluated the health status of the patient based on the reported adverse events, with a classification in 4 different states (correct, compromise, state to be monitored, or critical state). The main objective was to evaluate the feasibility of remote monitoring via a connected platform of patients included in a clinical trial.

Results

From July 1, 2020, to March 31, 2021, 39 patients were included. The median age was 71 years (range 41-94); 74% (n=29) were male, and 59% (n=23) had metastatic disease. Out of the 969 ePRO questionnaires completed over the course of the study, 77.0% (n=746) were classified as “correct,” 10.9% (n=106) as “compromised,” and 12.1% (n=117) as “to be monitored” or “critical.” The median response time was 7 days (IQR 7-15.5), and 76% (25/33) of the patients were compliant. Out of the 35 patients who answered a satisfaction questionnaire, 95% (n=33) were satisfied or very satisfied with the tool, and 85% (n=30) were satisfied with their relationship with the health care team. There were 5 unscheduled hospitalizations during the study period.

Conclusions

Remote monitoring in clinical trials is feasible, with a high level of patient participation and satisfaction. It benefits patients, but it also ensures the high quality of the trial through the early management of adverse events and better knowledge of the tolerance profile of experimental treatments. This e-technology will likely be deployed more widely in our clinical trials.