bluuebunny/crossref_metadata_2025 huggingface dataset:
Unintentional Child and Adolescent Drowning Mortality from 2000 to 2013 in 21 Countries: Analysis of the WHO Mortality Database
Authors: Wu Yue , Huang Yun , Schwebel David , Hu Guoqing
Published: August 2017

Limited research considers change over time for drowning mortality among individuals under 20 years of age, or the sub-cause (method) of those drownings. We assessed changes in under-20 drowning mortality from 2000 to 2013 among 21 countries. Age-standardized drowning mortality data were obtained through the World Health Organization (WHO) Mortality Database. Twenty of the 21 included countries experienced a reduction in under-20 drowning mortality rate between 2000 and 2013, with decreases ranging from −80 to −13%. Detailed analysis by drowning method presented large variations in the cause of drowning across countries. Data were missing due to unspecified methods in some countries but, when known, drowning in natural bodies of water was the primary cause of child and adolescent drowning in Poland (56–92%), Cuba (53–81%), Venezuela (43–56%), and Japan (39–60%), while drowning in swimming pools and bathtubs was common in the United States (26–37%) and Japan (28–39%), respectively. We recommend efforts to raise the quality of drowning death reporting systems and discuss prevention strategies that may reduce child and adolescent drowning risk, both in individual countries and globally.
Workplace Violence toward Physicians and Nurses: Prevalence and Correlates in Macau
Authors: Cheung Teris , Lee Paul , Yip Paul
Published: August 2017

This paper sets out to estimate the prevalence of workplace violence in relation to socio-demographic characteristics of physicians and nurses working in healthcare settings in Macau. Background: Concerted efforts worldwide to reduce workplace violence (WPV) have not yet removed medical-related professionals from the threat of patients’, family members’, and colleagues’ physical and other assaults in Southeast Asia. Methods: The study employs a cross-sectional design to estimate the prevalence and examines the socio-economic and psychological correlates of WPV among medical doctors and nurses in Macau. The data collection period spanned from August to December 2014. Multiple logistic regression examines the prevalence rates of WPV and its associated factors in doctors and nurses. Results: A total of 107 doctors (14.9%) and 613 nurses (85.1%) participated in the study; 57.2% had suffered WPV in the preceding year. The most common forms of workplace violence were verbal abuse (53.4%), physical assault (16.1%), bullying/harassment (14.2%), sexual harassment (4.6%), and racial harassment (2.6%). Most violence was perpetrated by patients and their relatives, colleagues, and supervisors. Conclusions: WPV remains a significant concern in healthcare settings in Macau. Macau’s local health authority should consider putting in place a raft of zero-tolerance policies designed to prevent it.
Biological Evaluation of Uridine Derivatives of 2-Deoxy Sugars as Potential Antiviral Compounds against Influenza A Virus
Authors: Krol Ewelina , Wandzik Ilona , Krejmer-Rabalska Martyna , Szewczyk Boguslaw
Published: August 2017

Influenza virus infection is a major cause of morbidity and mortality worldwide. Due to the limited ability of currently available treatments, there is an urgent need for new anti-influenza drugs with broad spectrum protection. We have previously shown that two 2-deoxy sugar derivatives of uridine (designated IW3 and IW7) targeting the glycan processing steps during maturation of viral glycoproteins show good anti-influenza virus activity and may be a promising alternative approach for the development of new anti-influenza therapy. In this study, a number of IW3 and IW7 analogues with different structural modifications in 2-deoxy sugar or uridine parts were synthesized and evaluated for their ability to inhibit influenza A virus infection in vitro. Using the cytopathic effect (CPE) inhibition assay and viral plaque reduction assay in vitro, we showed that compounds 2, 3, and 4 exerted the most inhibitory effect on influenza virus A/ostrich/Denmark/725/96 (H5N2) infection in Madin-Darby canine kidney (MDCK) cells, with 50% inhibitory concentrations (IC50) for virus growth ranging from 82 to 100 (μM) without significant toxicity for the cells. The most active compound (2) showed activity of 82 μM with a selectivity index value of 5.27 against type A (H5N2) virus. Additionally, compound 2 reduced the formation of HA glycoprotein in a dose-dependent manner. Moreover, an analysis of physicochemical properties of studied compounds demonstrated a significant linear correlation between lipophilicity and antiviral activity. Therefore, inhibition of influenza A virus infection by conjugates of uridine and 2-deoxy sugars is a new promising approach for the development of new derivatives with anti-influenza activities.
Influence of a Virgin Olive Oil versus Butter Plus Cholesterol-Enriched Diet on Testicular Enzymatic Activities in Adult Male Rats
Authors: Domínguez-Vías Germán , Segarra Ana , Martínez-Cañamero Magdalena , Ramírez-Sánchez Manuel , Prieto Isabel
Published: August 2017

The aim of the present work was to improve our knowledge on the mechanisms underlying the beneficial or deleterious effects on testicular function of the so-called Mediterranean and Western diet by analyzing glutamyl aminopeptidase (GluAP), gamma glutamyl transpeptidase (GGT) and dipeptidyl peptidase IV (DPP IV) activities in testis, as enzymes involved in testicular function. Male Wistar rats (6 months old) were fed for 24 weeks with three different diets: standard (S), an S diet supplemented with virgin-olive-oil (20%) (VOO), or a S diet enriched with butter (20%) plus cholesterol (0.1%) (Bch). At the end of the experimental period, plasma lipid profiled (total triglycerides, total cholesterol and cholesterol fractions (HDL, LDL and VDL)) were measured. Enzymatic activities were determined by fluorimetric methods in soluble (sol) and membrane-bound (mb) fractions of testicular tissue using arylamide derivatives as substrates. Results indicated an increase in plasmatic triglycerides, total cholesterol, LDL and VLDL in Bch. A significant increase of mb GluAP and GGT activities was also found in this diet in comparison with the other two diets. Furthermore, significant and positive correlations were established between these activities and plasma triglycerides and/or total cholesterol. These results support a role for testicular GluAP and GGT activities in the effects of saturated fat (Western diet) on testicular functions. In contrast, VOO increased sol DPP IV activity in comparison with the other two diets, which support a role for this activity in the effects of monounsaturated fat (Mediterranean diet) on testicular function. The present results strongly support the influence of fatty acids and cholesterol on testicular GluAP and GGT activities and also provide support that the reported beneficial influence of the Mediterranean diet in male fertility may be mediated in part by an increase of testicular sol DPP IV activity.
Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome
Authors: Rysz Jacek , Gluba-Brzózka Anna , Franczyk Beata , Jabłonowski Zbigniew , Ciałkowska-Rysz Aleksandra
Published: August 2017

In its early stages, symptoms of chronic kidney disease (CKD) are usually not apparent. Significant reduction of the kidney function is the first obvious sign of disease. If diagnosed early (stages 1 to 3), the progression of CKD can be altered and complications reduced. In stages 4 and 5 extensive kidney damage is observed, which usually results in end-stage renal failure. Currently, the diagnosis of CKD is made usually on the levels of blood urea and serum creatinine (sCr), however, sCr has been shown to be lacking high predictive value. Due to the development of genomics, epigenetics, transcriptomics, proteomics, and metabolomics, the introduction of novel techniques will allow for the identification of novel biomarkers in renal diseases. This review presents some new possible biomarkers in the diagnosis of CKD and in the prediction of outcome, including asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), uromodulin, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), miRNA, ncRNA, and lincRNA biomarkers and proteomic and metabolomic biomarkers. Complicated pathomechanisms of CKD development and progression require not a single marker but their combination in order to mirror all types of alterations occurring in the course of this disease. It seems that in the not so distant future, conventional markers may be exchanged for new ones, however, confirmation of their efficacy, sensitivity and specificity as well as the reduction of analysis costs are required.
The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice
Authors: Nakatsu Yusuke , Kokubo Hiroki , Bumdelger Batmunkh , Yoshizumi Masao , Yamamotoya Takeshi , Matsunaga Yasuka , Ueda Koji , Inoue Yuki , Inoue Masa-Ki , Fujishiro Midori , Kushiyama Akifumi , Ono Hiraku , Sakoda Hideyuki , Asano Tomoichiro
Published: August 2017

Recent clinical studies have revealed the treatment of diabetic patients with sodium glucose co-transporter2 (SGLT2) inhibitors to reduce the incidence of cardiovascular events. Using nicotinamide and streptozotocin (NA/STZ) -treated ApoE KO mice, we investigated the effects of short-term (seven days) treatment with the SGLT2 inhibitor luseogliflozin on mRNA levels related to atherosclerosis in the aorta, as well as examining the long-term (six months) effects on atherosclerosis development. Eight-week-old ApoE KO mice were treated with NA/STZ to induce diabetes mellitus, and then divided into two groups, either untreated, or treated with luseogliflozin. Seven days after the initiation of luseogliflozin administration, atherosclerosis-related mRNA levels in the aorta were compared among four groups; i.e., wild type C57/BL6J, native ApoE KO, and NA/STZ-treated ApoE KO mice, with or without luseogliflozin. Short-term luseogliflozin treatment normalized the expression of inflammation-related genes such as F4/80, TNFα, IL-1β, IL-6, ICAM-1, PECAM-1, MMP2 and MMP9 in the NA/STZ-treated ApoE KO mice, which showed marked elevations as compared with untreated ApoE KO mice. In contrast, lipid metabolism-related genes were generally unaffected by luseogliflozin treatment. Furthermore, after six-month treatment with luseogliflozin, in contrast to the severe and widely distributed atherosclerotic changes in the aortas of NA/STZ-treated ApoE KO mice, luseogliflozin treatment markedly attenuated the progression of atherosclerosis, without affecting serum lipid parameters such as high density lipoprotein, low density lipoprotein and triglyceride levels. Given that luseogliflozin normalized the aortic mRNA levels of inflammation-related, but not lipid-related, genes soon after the initiation of treatment, it is not unreasonable to speculate that the anti-atherosclerotic effect of this SGLT2 inhibitor emerges rapidly, possibly via the prevention of inflammation rather than of hyperlipidemia.
Artificial Auricular Cartilage Using Silk Fibroin and Polyvinyl Alcohol Hydrogel
Authors: Lee Jung , Sultan Md. , Kim Soon , Kumar Vijay , Yeon Yeung , Lee Ok , Park Chan
Published: August 2017

Several methods for auricular cartilage engineering use tissue engineering techniques. However, an ideal method for engineering auricular cartilage has not been reported. To address this issue, we developed a strategy to engineer auricular cartilage using silk fibroin (SF) and polyvinyl alcohol (PVA) hydrogel. We constructed different hydrogels with various ratios of SF and PVA by using salt leaching, silicone mold casting, and freeze-thawing methods. We characterized each of the hydrogels in terms of the swelling ratio, tensile strength, pore size, thermal properties, morphologies, and chemical properties. Based on the cell viability results, we found a blended hydrogel composed of 50% PVA and 50% SF (P50/S50) to be the best hydrogel among the fabricated hydrogels. An intact 3D ear-shaped auricular cartilage formed six weeks after the subcutaneous implantation of a chondrocyte-seeded 3D ear-shaped P50/S50 hydrogel in rats. We observed mature cartilage with a typical lacunar structure both in vitro and in vivo via histological analysis. This study may have potential applications in auricular tissue engineering with a human ear-shaped hydrogel.
Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2-carboxylate
Authors: Baumann Marcus , Baxendale Ian
Published: August 2017

This note describes a sequence converting an oxime-substituted pyrrolidine into a trisubstituted pyrrole structure. The synthetic route is based on a double chlorination of the pyrrolidine substrate followed by the base induced formation of both an imine and a nitrile oxide functionality. The latter reacts with an immobilized thiourea to yield an isothiocyanate which upon elimination generates the final pyrrole in an unprecedented cascade of events.
Pitting Corrosion Behaviour of New Corrosion-Resistant Reinforcement Bars in Chloride-Containing Concrete Pore Solution
Authors: Jiang Jin-yang , Liu Yao , Chu Hong-yan , Wang Danqian , Ma Han , Sun Wei
Published: August 2017

In this study, the pitting behaviour of a new corrosion-resistant alloy steel (CR) is compared to that of low-carbon steel (LC) in a simulated concrete pore solution with a chloride concentration of 5 mol/L. The electrochemical behaviour of the bars was characterised using linear polarisation resistance (LPR) and electrochemical impedance spectroscopy (EIS). The pitting profiles were detected by reflective digital holographic microscopy (DHM), scanning electron microscopy (SEM), and the chemical components produced in the pitting process were analysed by X-ray energy dispersive spectroscopy (EDS). The results show that the CR bars have a higher resistance to pitting corrosion than the LC bars. This is primarily because of the periodic occurrence of metastable pitting during pitting development. Compared to the pitting process in the LC bars, the pitting depth grows slowly in the CR bars, which greatly reduces the risk of pitting. The possible reason for this result is that the capability of the CR bars to heal the passivation film helps to restore the metastable pits to the passivation state.
Growth and Photosynthetic Characteristics of Toxic and Non-Toxic Strains of the Cyanobacteria Microcystis aeruginosa and Anabaena circinalis in Relation to Light
Authors: Islam M. , Beardall John
Published: August 2017

Cyanobacteria are major bloom-forming organisms in freshwater ecosystems and many strains are known to produce toxins. Toxin production requires an investment in energy and resources. As light is one of the most important factors for cyanobacterial growth, any changes in light climate might affect cyanobacterial toxin production as well as their growth and physiology. To evaluate the effects of light on the growth and physiological parameters of both toxic and non-toxic strains of Microcystis aeruginosa and Anabaena circinalis, cultures were grown at a range of light intensities (10, 25, 50, 100, 150 and 200 µmol m−2 s−1). The study revealed that the toxic strains of both species (CS558 for M. aeruginosa and CS537 and CS541 for A. circinalis) showed growth (µ) saturation at a higher light intensity compared to the non-toxic strains (CS338 for M. aeruginosa and CS534 for A. circinalis). Both species showed differences in chlorophyll a, carotenoid, allophycocyanin (APC) and phycoerythrin (PE) content between strains. There were also differences in dark respiration (Rd), light saturated oxygen evolution rates (Pmax) and efficiency of light harvesting (α) between strains. All other physiological parameters showed no statistically significant differences between strains. This study suggest that the different strains respond differently to different light habitats. Thus, changes in light availability may affect bloom intensity of toxic and nontoxic strains of cyanobacteria by changing the dominance and succession patterns.
Soymilk Improves Muscle Weakness in Young Ovariectomized Female Mice
Authors: Kitajima Yuriko , Ogawa Shizuka , Egusa Shintaro , Ono Yusuke
Published: August 2017

Estrogens play a key role in an extensive range of physiological functions in various types of tissues throughout the body in females. We previously showed that estrogen insufficiency caused muscle weakness that could be rescued by estrogen administration in a young female ovariectomized (OVX) mouse model. However, long-term estrogen replacement therapy increases risks of breast cancer and cardiovascular diseases. Soymilk contains plant-based protein and isoflavones that exert estrogen-like activity. Here we examined the effects of prolonged soymilk intake on muscle and its resident stem cells, called satellite cells, in the estrogen-insufficient model. Six-week-old C57BL/6 OVX female mice were fed with a dried soymilk-containing diet. We found that prolonged soymilk intake upregulated grip strength in OVX mice. Correspondingly, cross-sectional area of tibialis anterior muscle was significantly increased in OVX mice fed with soymilk. Furthermore, soymilk diet mitigated dysfunction of satellite cells isolated from OVX mice. Thus, these results indicated that prolonged soymilk intake is beneficial for improving muscle weakness in an estrogen-insufficient state in females.
Changes in Consumer Attitudes toward Broad-Based and Environment-Specific Sodium Policies—SummerStyles 2012 and 2015
Authors: Odom Erika , Whittick Corine , Tong Xin , John Katherine , Cogswell Mary
Published: August 2017

We examined temporal changes in consumer attitudes toward broad-based actions and environment-specific policies to limit sodium in restaurants, manufactured foods, and school and workplace cafeterias from the 2012 and 2015 SummerStyle surveys. We used two online, national research panel surveys to conduct a cross-sectional analysis of 7845 U.S. adults. Measures included self-reported agreement with broad-based actions and environment-specific policies to limit sodium in restaurants, manufactured foods, school cafeterias, workplace cafeterias, and quick-serve restaurants. Wald Chi-square tests were used to examine the difference between the two survey years and multivariate logistic regression was used to obtain odds ratios. Agreement with broad-based actions to limit sodium in restaurants (45.9% agreed in 2015) and manufactured foods (56.5% agreed in 2015) did not change between 2012 and 2015. From 2012 to 2015, there was a significant increase in respondents that supported environment-specific policies to lower sodium in school cafeterias (80.0% to 84.9%; p < 0.0001), workplace cafeterias (71.2% to 76.6%; p < 0.0001), and quick-serve restaurants (70.8% to 76.7%; p < 0.0001). Results suggest substantial agreement and support for actions to limit sodium in commercially-processed and prepared foods since 2012, with most consumers ready for actions to lower sodium in foods served in schools, workplaces, and quick-serve restaurants.
Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements
Authors: Ganz Ariel , Klatt Kevin , Caudill Marie
Published: August 2017

Nutrient needs, including those of the essential nutrient choline, are a population wide distribution. Adequate Intake (AI) recommendations for dietary choline (put forth by the National Academies of Medicine to aid individuals and groups in dietary assessment and planning) are grouped to account for the recognized unique needs associated with age, biological sex, and reproductive status (i.e., pregnancy or lactation). Established and emerging evidence supports the notion that common genetic variants are additional factors that substantially influence nutrient requirements. This review summarizes the genetic factors that influence choline requirements and metabolism in conditions of nutrient deprivation, as well as conditions of nutrient adequacy, across biological sexes and reproductive states. Overall, consistent and strong associative evidence demonstrates that common genetic variants in choline and folate pathway enzymes impact the metabolic handling of choline and the risk of nutrient inadequacy across varied dietary contexts. The studies characterized in this review also highlight the substantial promise of incorporating common genetic variants into choline intake recommendations to more precisely target the unique nutrient needs of these subgroups within the broader population. Additional studies are warranted to facilitate the translation of this evidence to nutrigenetics-based dietary approaches.
Safety of People with Intellectual Disabilities in Hospital. What Can the Hospital Pharmacist Do to Improve Quality of Care?
Authors: Flood Bernadette
Published: August 2017

People with intellectual disabilities are vulnerable in healthcare environments. They experience health and healthcare inequalities, and when admitted to general hospitals are at a greater risk of patient safety incidents. This is well known in specialist services, but less recognized within primary or secondary healthcare. The most significant barriers to safer and better healthcare appear to include ‘invisibility’ of people with intellectual disabilities within health-care systems, widespread lack of staff understanding of intellectual disability, the vulnerabilities of people with intellectual disabilities, and the reasonable adjustment they may need in order to access health-care services. They may be ‘invisible’ to pharmacists in general hospitals. This article aims to raise awareness among those pharmacists and others providing care and support to people with intellectual disabilities in hospital in relation to how pharmacists can contribute to safety. Medication is the main therapeutic intervention in this population. Research is needed to determine the role of pharmacists in improving health outcomes and reducing health inequalities in this vulnerable population group when they are admitted to general hospitals.
Preparation and Characterization of Thermo-Responsive Rod-Coil Diblock Copolymers
Authors: Yu Yang-Yen , Chien Wen-Chen , Tsai Chia-Liang
Published: August 2017

In this study, we synthesized amphiphilic poly(2,7–(9,9–dioctylfluorene))–block–N,N–(diisopropylamino)ethyl methacrylate (POF–b–PDPMAEMA) rod-coil diblock copolymers by atom transfer radical polymerization (ATRP). The structure and multifunctional sensing properties of these copolymers were also investigated. The POF rod segment length of 10 was fixed and the PDPAEMA coil segment lengths of 90 and 197 were changed, respectively. The micellar aggregates of POF10–b–PDPAEMA90 rod-coil diblock copolymer in water showed a reversible shape transition from cylinder bundles to spheres when the temperature was changed from 20 to 80 °C or the pH was changed from 11 to 2. The atomic force microscopy (AFM) and transmission electron microscopy (TEM) measurements indicated that the temperature had also an obvious influence on the micelle size. In addition, since POF10–b–PDPAEMA90 had a lower critical solution temperature, its photoluminescence (PL) intensity in water is thermoreversible. The PL spectra showed that the POF–b–PDPAEMA copolymer had a reversible on/off profile at elevated temperatures, and thus could be used as an on/off fluorescent indicator for temperature or pH. The fluorescence intensity distribution of pH switched from “off–on” to “on–off” as the temperature increased. These results showed that the POF–b–PDPAEMA copolymer has a potential application for temperature and pH sensing materials.
Design of Experiments for Control-Relevant Multivariable Model Identification: An Overview of Some Basic Recent Developments
Authors: Misra Shobhit , Darby Mark , Panjwani Shyam , Nikolaou Michael
Published: August 2017

The effectiveness of model-based multivariable controllers depends on the quality of the model used. In addition to satisfying standard accuracy requirements for model structure and parameter estimates, a model to be used in a controller must also satisfy control-relevant requirements, such as integral controllability. Design of experiments (DOE), which produce data from which control-relevant models can be accurately estimated, may differ from standard DOE. The purpose of this paper is to emphasize this basic principle and to summarize some fundamental results obtained in recent years for DOE in two important cases: Accurate estimation of the order of a multivariable model and efficient identification of a model that satisfies integral controllability; both important for the design of robust model-based controllers. For both cases, we provide an overview of recent results that can be easily incorporated by the final user in related DOE. Computer simulations illustrate outcomes to be anticipated. Finally, opportunities for further development are discussed.
A Scientometric Visualization Analysis for Night-Time Light Remote Sensing Research from 1991 to 2016
Authors: Hu Kai , Qi Kunlun , Guan Qingfeng , Wu Chuanqing , Yu Jingmin , Qing Yaxian , Zheng Jie , Wu Huayi , Li Xi
Published: August 2017

In this paper, we conducted a scientometric analysis based on the Night-Time Light (NTL) remote sensing related literature datasets retrieved from Science Citation Index Expanded and Social Science Citation Index in Web of Science core collection database. Using the methods of bibliometric and Social Network Analysis (SNA), we drew several conclusions: (1) NTL related studies have become a research hotspot, especially after 2011 when the second generation of NTL satellites, the Suomi National Polar-orbiting Partnership (S-NPP) Satellite with the Visible Infrared Imaging Radiometer Suite (VIIRS) sensor was on board. In the same period, the open-access policy of the long historical dataset of the first generation satellite Defense Meteorological Satellite Program’s Operational Linescan System (DMSP/OLS) started. (2) Most related studies are conducted by authors from USA and China, and the USA takes the lead in the field. We identified the biggest research communities constructed by co-authorships and the related important authors and topics by SNA. (3) By the visualization and analysis of the topic evolution using the co-word and co-cited reference networks, we can clearly see that: the research topics change from hardware oriented studies to more real-world applications; and from the first generation of the satellite DMSP/OLS to the second generation of satellite S-NPP. Although the Day Night Band (DNB) of the S-NPP exhibits higher spatial and radiometric resolution and better calibration conditions than the first generation DMSP/OLS, the longer historical datasets in DMSP/OLS are still important in long-term and large-scale human activity analysis. (4) In line with the intuitive knowledge, the NTL remote sensing related studies display stronger connections (such as interpretive frame, context, and academic purpose) to the social sciences than the general remote sensing discipline. The citation trajectories are visualized based on the dual-maps, thus the research preferences for combining the environmental, ecological, economic, and political science disciplines are clearly exhibited. Overall, the picture of the NTL remote sensing research is presented from the scientist-level, topic-level, and discipline-level interactions. Based on these analyses, we also discuss the possible trends in the future work, such as combining NTL studies with social science research and social media data.
III–V-on-Silicon Photonic Integrated Circuits for Spectroscopic Sensing in the 2–4 μm Wavelength Range
Authors: Wang Ruijun , Vasiliev Anton , Muneeb Muhammad , Malik Aditya , Sprengel Stephan , Boehm Gerhard , Amann Markus-Christian , Šimonytė Ieva , Vizbaras Augustinas , Vizbaras Kristijonas , Baets Roel , Roelkens Gunther
Published: August 2017

The availability of silicon photonic integrated circuits (ICs) in the 2–4 μm wavelength range enables miniature optical sensors for trace gas and bio-molecule detection. In this paper, we review our recent work on III–V-on-silicon waveguide circuits for spectroscopic sensing in this wavelength range. We first present results on the heterogeneous integration of 2.3 μm wavelength III–V laser sources and photodetectors on silicon photonic ICs for fully integrated optical sensors. Then a compact 2 μm wavelength widely tunable external cavity laser using a silicon photonic IC for the wavelength selective feedback is shown. High-performance silicon arrayed waveguide grating spectrometers are also presented. Further we show an on-chip photothermal transducer using a suspended silicon-on-insulator microring resonator used for mid-infrared photothermal spectroscopy.
A Compact Energy Harvesting System for Outdoor Wireless Sensor Nodes Based on a Low-Cost In Situ Photovoltaic Panel Characterization-Modelling Unit
Authors: Antolín Diego , Medrano Nicolás , Calvo Belén , Martínez Pedro
Published: August 2017

This paper presents a low-cost high-efficiency solar energy harvesting system to power outdoor wireless sensor nodes. It is based on a Voltage Open Circuit (VOC) algorithm that estimates the open-circuit voltage by means of a multilayer perceptron neural network model trained using local experimental characterization data, which are acquired through a novel low cost characterization system incorporated into the deployed node. Both units—characterization and modelling—are controlled by the same low-cost microcontroller, providing a complete solution which can be understood as a virtual pilot cell, with identical characteristics to those of the specific small solar cell installed on the sensor node, that besides allows an easy adaptation to changes in the actual environmental conditions, panel aging, etc. Experimental comparison to a classical pilot panel based VOC algorithm show better efficiency under the same tested conditions.
Current Status of HbA1c Biosensors
Authors: Lin Hua , Yi Jun
Published: August 2017

Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the α–amino group of βVal1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, enzymatic measurement, electrochemical sensor and capillary electrophoresis have been developed and used in research laboratories and in clinics as well. In this review, we summarize the current status of HbA1c biosensors based on the recognition of the sugar moiety on the protein and also their applications in the whole blood sample measurements.
Effects of Heart Rate vs. Speed-Based High Intensity Interval Training on Aerobic and Anaerobic Capacity of Female Soccer Players
Authors: Arazi Hamid , Keihaniyan Abbas , EatemadyBoroujeni Amin , Oftade Amir , Takhsha Sheida , Asadi Abbas , Ramirez-Campillo Rodrigo
Published: August 2017

The purpose of this study was to compare the effects of two types of high-intensity interval training (HIIT) programs on aerobic and anaerobic capacity of female soccer players. Regional-level female athletes were randomly divided into heart rate-based HIIT (n = 8; age 23.4 ± 1.1 year) and speed-based HIIT groups (n = 8; age 23.4 ± 1.3 year). Athletes trained three days per week for six weeks. Before and after training, each athlete’s performance was assessed directly through the Hoff test, 30-15 Intermittent Fitness Test (VIFT), and repeated-sprint ability test (RAST); maximal oxygen consumption (VO2max), power and fatigue were estimated indirectly. Both experimental groups improved power, fatigue index and VO2max after training (p < 0.05). It was noteworthy that the speed-based group had greater gains in minimal power (effect size (ES): 3.99 vs. 0.75), average power (ES: 2.23 vs. 0.33), and fatigue index (ES: 2.53 vs. 0.17) compared to heart rate-based group (p < 0.05). In conclusion, both heart rate-based and speed-based HIIT induced meaningful improvements in power, VO2max, and fatigue index in female soccer players, although the speed-based HIIT group achieved greater gains in power and fatigue index compared to the heart rate-based group.
Demand Forecasting in the Early Stage of the Technology’s Life Cycle Using a Bayesian Update
Authors: Lee Chul-Yong , Lee Min-Kyu
Published: August 2017

The forecasting demand for new technology for which few historical data observations are available is difficult but essential to sustainable development. The current study suggests an alternative forecasting methodology based on a hazard rate model using stated and revealed preferences of consumers. In estimating the hazard rate, information is initially derived through conjoint analysis based on a consumer survey and then updated using Bayes’ theorem with available market data. To compare the proposed models’ performance with benchmark models, the Bass model, the logistic growth model, and a Bayesian approach based on analogy are adopted. The results show that the proposed model outperforms the benchmark models in terms of pre-launch and post-launch forecasting performances.
Characterization and Treatment Proposals of Shipboard Slop Wastewater Contaminated by Hydrocarbons
Authors: Campo Riccardo , Giustra Maria , De Marchis Mauro , Freni Gabriele , Di Bella Gaetano
Published: August 2017

Shipboard slop wastewaters are produced by the activity of washing of oil tankers with seawater, and are characterized by high salinity and hydrocarbons. In this context, harbor authorities are forced to respect the international regulation IMO-MARPOL 73/78 and they must treat slop wastewater before discharging to the sea. This study compared data from three stand-alone treatments working with the same real slop wastewater: (1) a chemical treatment of coagulation-flocculation with aluminum sulphate as coagulant and an anionic flocculant (A57), (2) a physical treatment of adsorption on granular activated carbon (GAC), (3) two biological treatments represented by a membrane bioreactor (MBR) and a moving bed biofilm reactor (MB-MBR). GAC treatment registered the highest removal efficiency of total petroleum hydrocarbons (ηTPH) next to 85%, since the activated carbon had excellent adsorption properties towards organic substances. The coagulation-flocculation treatment reported the lowest ηTPH ≈ 57% due to the presence of emulsified hydrocarbons that were not affected by the coagulant and flocculant action, so remaining in liquid phase. ηTPH ≈ 70% obtained with MB-MBR fed with 100% volume of slop, suggested biomass acclimation to salinity and hydrocarbons. Based on the results of each process, three main treatment chains are proposed depending on the hydrocarbons load of the real slop wastewater.
Synthesis and metal binding properties of N-alkylcarboxyspiropyrans
Authors: Perry Alexis , Kousseff Christina J
Published: August 2017

Spiropyrans bearing an N-alkylcarboxylate tether are a common structure in dynamic, photoactive materials and serve as colourimetric/fluorimetric cation receptors. In this study, we describe an efficient synthesis of spiropyrans with 2–12 carbon atom alkylcarboxylate substituents, and a systematic analysis of their interactions with metal cations using 1H NMR and UV-visible spectroscopy. All N-alkylcarboxyspiropyrans in this study displayed a strong preference for binding divalent metal cations and a modest increase in M2+ binding affinity correlated with increased alkycarboxylate tether length.
The Structure of the Young Star Cluster NGC 6231. I. Stellar Population
Authors: Kuhn Michael A. , Medina Nicolás , Getman Konstantin V. , Feigelson Eric D. , Gromadzki Mariusz , Borissova Jordanka , Kurtev Radostin
Published: August 2017

NGC 6231 is a young cluster (age ∼2–7 Myr) dominating the Sco OB1 association (distance ∼1.59 kpc) with ∼100 O and B stars and a large pre-main-sequence stellar population. We combine a reanalysis of archival Chandra X-ray data with multiepoch near-infrared (NIR) photometry from the VISTA Variables in the Vía Lactéa (VVV) survey and published optical catalogs to obtain a catalog of 2148 probable cluster members. This catalog is 70% larger than previous censuses of probable cluster members in NGC 6231. It includes many low-mass stars detected in the NIR but not in the optical and some B stars without previously noted X-ray counterparts. In addition, we identify 295 NIR variables, about half of which are expected to be pre-main-sequence stars. With the more complete sample, we estimate a total population in the Chandra field of 5700–7500 cluster members down to 0.08 

(assuming a universal initial mass function) with a completeness limit at 0.5 

. A decrease in stellar X-ray luminosities is noted relative to other younger clusters. However, within the cluster, there is little variation in the distribution of X-ray luminosities for ages less than 5 Myr. The X-ray spectral hardness for B stars may be useful for distinguishing between early-B stars with X-rays generated in stellar winds and B-star systems with X-rays from a pre-main-sequence companion (>35% of B stars). A small fraction of catalog members have unusually high X-ray median energies or reddened NIR colors, which might be explained by absorption from thick or edge-on disks or being background field stars.
Supervised Learning Detection of Sixty Non-transiting Hot Jupiter Candidates
Authors: Millholland Sarah , Laughlin Gregory
Published: August 2017

The optical full-phase photometric variations of a short-period planet provide a unique view of the planet’s atmospheric composition and dynamics. The number of planets with optical phase curve detections, however, is currently too small to study them as an aggregate population, motivating an extension of the search to non-transiting planets. Here we present an algorithm for the detection of non-transiting short-period giant planets in the Kepler field. The procedure uses the phase curves themselves as evidence for the planets’ existence. We employ a supervised learning algorithm to recognize the salient time-dependent properties of synthetic phase curves; we then search for detections of signals that match these properties. After demonstrating the algorithm’s capabilities, we classify 142,630 FGK Kepler stars without confirmed planets or Kepler Objects of Interest, and for each one, we assign a probability of a phase curve of a non-transiting planet being present. We identify 60 high-probability non-transiting hot Jupiter candidates. We also derive constraints on the candidates’ albedos and offsets of the phase curve maxima. These targets are strong candidates for follow-up radial velocity confirmation and characterization. Once confirmed, the atmospheric information content in the phase curves may be studied in yet greater detail.
The SDSS-IV MaNGA Sample: Design, Optimization, and Usage Considerations
Authors: Wake David A. , Bundy Kevin , Diamond-Stanic Aleksandar M. , Yan Renbin , Blanton Michael R. , Bershady Matthew A. , Sánchez-Gallego José R. , Drory Niv , Jones Amy , Kauffmann Guinevere , Law David R. , Li Cheng , MacDonald Nicholas , Masters Karen , Thomas Daniel , Tinker Jeremy , Weijmans Anne-Marie , Brownstein Joel R.
Published: August 2017

We describe the sample design for the SDSS-IV MaNGA survey and present the final properties of the main samples along with important considerations for using these samples for science. Our target selection criteria were developed while simultaneously optimizing the size distribution of the MaNGA integral field units (IFUs), the IFU allocation strategy, and the target density to produce a survey defined in terms of maximizing signal-to-noise ratio, spatial resolution, and sample size. Our selection strategy makes use of redshift limits that only depend on i-band absolute magnitude (M

i
), or, for a small subset of our sample, M

i
 and color (NUV − i). Such a strategy ensures that all galaxies span the same range in angular size irrespective of luminosity and are therefore covered evenly by the adopted range of IFU sizes. We define three samples: the Primary and Secondary samples are selected to have a flat number density with respect to M

i
 and are targeted to have spectroscopic coverage to 1.5 and 2.5 effective radii (R

e
), respectively. The Color-Enhanced supplement increases the number of galaxies in the low-density regions of color–magnitude space by extending the redshift limits of the Primary sample in the appropriate color bins. The samples cover the stellar mass range

and are sampled at median physical resolutions of 1.37 and 2.5 kpc for the Primary and Secondary samples, respectively. We provide weights that will statistically correct for our luminosity and color-dependent selection function and IFU allocation strategy, thus correcting the observed sample to a volume-limited sample.
Absolute Magnitudes and Colors of RR Lyrae Stars in DECam Passbands from Photometry of the Globular Cluster M5
Authors: Vivas A. Katherina , Saha Abhijit , Olsen Knut , Blum Robert , Olszewski Edward W. , Claver Jennifer , Valdes Francisco , Axelrod Tim , Kaleida Catherine , Kunder Andrea , Narayan Gautham , Matheson Thomas , Walker Alistair
Published: August 2017

We characterize the absolute magnitudes and colors of RR Lyrae stars in the globular cluster M5 in the ugriz filter system of the Dark Energy Camera (DECam). We provide empirical period–luminosity (P–L) relationships in all five bands based on 47 RR Lyrae stars of the type ab and 14 stars of the type c. The P–L relationships were found to be better constrained for the fundamental-mode RR Lyrae stars in the riz passbands, with dispersions of 0.03, 0.02 and 0.02 mag, respectively. The dispersion of the color at minimum light was found to be small, supporting the use of this parameter as a means to obtain accurate interstellar extinctions along the line of sight up to the distance of the RR Lyrae star. We found a trend of color at minimum light with a pulsational period that, if taken into account, brings the dispersion in color at minimum light to

mag for the

,

, and

colors. These calibrations will be very useful for using RR Lyrae stars from DECam observations as both standard candles for distance determinations and color standards for reddening measurements.
Simultaneous Constraints on the Mass and Radius of Aql X–1 from Quiescence and X-Ray Burst Observations
Authors: Li Zhaosheng , Falanga Maurizio , Chen Li , Qu Jinlu , Xu Renxin
Published: August 2017

The measurement of neutron star mass and radius is one of the most direct ways to distinguish between various dense matter equations of state. The mass and radius of accreting neutron stars hosted in low-mass X-ray binaries can be constrained by several methods, including photospheric radius expansion from type I X-ray bursts and from quiescent spectra. In this paper, we apply for the first time these two methods simultaneously to constrain the mass and radius of Aql X–1. The quiescent spectra from Chandra and XMM-Newton, and photospheric radius expansion bursts from RXTE are used. The determination of the mass and radius of Aql X–1 is also used to verify the consistency between the two methods and to narrow down the uncertainties of the neutron star mass and radius. It is found that the distance to Aql X–1 should be in the range of 4.0–5.75 kpc, based on the overlapping confidence regions between photospheric radius expansion burst and quiescent spectra methods. In addition, we show that the mass and radius determined for the compact star in Aql X–1 are compatible with strange star equations of state and conventional neutron star models.
Three-dimensional Features of the Outer Heliosphere Due to Coupling between the Interstellar and Heliospheric Magnetic Field. V. The Bow Wave, Heliospheric Boundary Layer, Instabilities, and Magnetic Reconnection
Authors: Pogorelov N. V. , Heerikhuisen J. , Roytershteyn V. , Burlaga L. F. , Gurnett D. A. , Kurth W. S.
Published: August 2017

The heliosphere is formed due to interaction between the solar wind (SW) and local interstellar medium (LISM). The shape and position of the heliospheric boundary, the heliopause, in space depend on the parameters of interacting plasma flows. The interplay between the asymmetrizing effect of the interstellar magnetic field and charge exchange between ions and neutral atoms plays an important role in the SW–LISM interaction. By performing three-dimensional, MHD plasma/kinetic neutral atom simulations, we determine the width of the outer heliosheath—the LISM plasma region affected by the presence of the heliosphere—and analyze quantitatively the distributions in front of the heliopause. It is shown that charge exchange modifies the LISM plasma to such extent that the contribution of a shock transition to the total variation of plasma parameters becomes small even if the LISM velocity exceeds the fast magnetosonic speed in the unperturbed medium. By performing adaptive mesh refinement simulations, we show that a distinct boundary layer of decreased plasma density and enhanced magnetic field should be observed on the interstellar side of the heliopause. We show that this behavior is in agreement with the plasma oscillations of increasing frequency observed by the plasma wave instrument onboard Voyager 1. We also demonstrate that Voyager observations in the inner heliosheath between the heliospheric termination shock and the heliopause are consistent with dissipation of the heliospheric magnetic field. The choice of LISM parameters in this analysis is based on the simulations that fit observations of energetic neutral atoms performed by Interstellar Boundary Explorer.
Midterm Periodicity Analysis of the Mount Wilson Magnetic Indices Using the Synchrosqueezing Transform
Authors: Feng Song , Yu Lan , Wang Feng , Deng Hui , Yang Yunfei
Published: August 2017

A novel time–frequency technique, called the synchrosqueezing transform (SST), is used to investigate the midterm periodic variations of magnetic fields on the solar surface. The Magnetic Plage Strength Index (MPSI) and the Mount Wilson Sunspot Index (MWSI), measured daily by the Mount Wilson Observatory between 1970 January 19 and 2012 January 22, are selected. Short-, mid, and longer-term periodicities are represented and decomposed by the SST with hardly any mode mixing. This demonstrates that the SST is a useful time–frequency analysis technique to characterize the periodic modes of helioseismic data. Apart from the fundamental modes of the annual periodicity, ∼27 day rotational cycle and ∼11 year solar cycle, the SST reveals several midterm periodicities in the two magnetic activity indices, specifically, ∼157 days (i.e., Rieger-type periodicity), and ∼1.3 and 1.7 years. The periodic modes, with 116.4 and 276.2 day periodicity in the MPSI, 108.5 and 251.6 day periodicity in the MWSI, and 157.7 day periodicity in the two indices, are in better accord with those significant periodicities derived from the Rossby waves theoretical model. This study suggests that the modes are caused by Rossby waves. For the 1.30 and 1.71 year periodicity of the MPSI, and the 1.33 and 1.67 year periodicity of the MWSI, our analysis infers that they are related to those periodicities with the same timescale in the interior of the Sun and in the high atmospheric layers.