bluuebunny/crossref_metadata_2025 huggingface dataset:
Influences of CO2 Absorption under Ultrasonic Vibration and Water-Reducer Addition on the Rheological Properties of Cement Paste
Authors: Liu Lili , Ji Yongsheng , Li Longhai , Zhang Jie
Published: April 2022

Research shows that ultrasonic vibratory stirring can effectively increase CO2 absorption by cement slurry. However, with the increase in CO2 absorption, the fluidity of slurry begins to decrease. Adding water reducer to fresh cement paste can improve its fluidity. In order to reveal the influences of ultrasonic vibration and water-reducer addition on the rheological properties of cement pastes after absorbing various amounts of CO2, changes in the rheological properties of yield stress and plastic viscosity (PV) were analysed. The results show that ultrasonic vibration can effectively increase the shear stress and PV of cement paste. Moreover, shear stress and PV are positively related to the CO2 absorption amount. Meanwhile, a new rheological model of cement paste carbonated under ultrasonic vibration was established based on the basic principles of rheology. Microstructural changes in cement paste before and after water-reducer addition were observed by scanning electron microscopy (SEM). A microrheological model of cement paste carbonated under ultrasonic vibration and with water reducer added was constructed. It describes the influencing mechanisms of ultrasonic vibration and water-reducer addition on the rheological properties of carbonated cement paste. Next, a molecular model was constructed in which CO2 was added into a C-S-H gel. Changes in intermolecular repulsion in the CO2+ C-S-H gel structure and in the CO2− water-reducer molecular structure were analysed. Finally, the rheological mechanism was further analysed in terms of the dispersion effect of the C-S-H gel. The results will play a major role in improving the fluidity of cement paste.
Correction: Berci, M. On Aerodynamic Models for Flutter Analysis: A Systematic Overview and Comparative Assessment. Appl. Mech. 2021, 2, 516–541
Authors: Berci Marco
Published: April 2022

Text Correction [...]
Sustainability Assessment on an Urban Scale: Context, Challenges, and Most Relevant Indicators
Authors: Salati Maryam , Bragança Luis , Mateus Ricardo
Published: April 2022

The concept and practice of sustainability in urban planning have gained worldwide significance since the early 2000s and have become increasingly mainstream in the policymaking process. Adopting global frameworks, such as the United Nations Sustainable Development Goals and ISO standards, for sustainable communities provides an opportunity to build more sustainable, innovative, and equitable towns and cities, with regard to natural resources and biodiversity. However, attaining sustainability requires addressing many fundamental issues at various levels, and achieving the goals and objectives of sustainability poses a significant challenge for all segments of society. Several methods for assessing the sustainability of the urban environment have been established in recent years. Therefore, compiling a short and comprehensive list of indicators addressing the broad concept of urban sustainability issues has arisen as a significant challenge. This research reviews four urban sustainability assessment tools—BREEAM-C, LEED-ND, iiSBE SBToolPT Urban, and iiSBE SNTool—to identify a clear set of key sustainability priorities. This study aims to highlight a more consistent list of indicators that are considered the most significant aspects and priorities within the analysed sustainability methods, allowing for a common understanding of the most important principles that must be considered in the design of sustainable urban areas and are compatible with the most recent standardization and sustainability targets. The end product of this study includes a proposal for a set of sustainability indicators to assess environmental, social, and economic issues to implement in the design of sustainable urban environments, independent of the local context.
Coughing Intensity and Wind Direction Effects on the Transmission of Respiratory Droplets: A Computation with Euler–Lagrange Method
Authors: Li Fengjiao , Jiang Guoyi , Hu Tingting
Published: April 2022

Studies on droplet transmission are needed to understand the infection mechanism of SARS-CoV-2. This research investigated the effects of coughing intensity and wind direction on respiratory droplets transportation using the Euler–Lagrange method. The results revealed that both coughing intensity and wind conditions considerably influence the transmission of small and medium droplets but had little effect on large droplets. A stronger coughing intensity resulted in small and medium droplets traveling farther in a calm wind and spreading widely and rapidly in a windy environment. The droplets do not travel far in the absence of ambient wind, even with stronger coughing. Medium droplets spread in clusters, and small droplets drifted out of the domain in the band area in different wind conditions except for 60° and 90° wind directions, in which cases, the droplets were blown directly downstream. In 0° wind direction, many droplets were deposited on the human body. The fast and upward movement of particles in 60° and 90° directions could cause infection risk with short exposure. In 180° wind direction, droplets spread widely and traveled slowly because of the reverse flow downstream, prolonged exposure can result in a high risk of infection.
Seasonal Paspalum vaginatum Physiological Characteristics Change with Agricultural Byproduct Biochar in Sandy Potting Soil
Authors: Fetjah Dounia , Idardare Zaina , Ihssane Bouchaib , Ainlhout Lalla Fatima Zohra , Bouqbis Laila
Published: April 2022

A plastic pot open-air trial was conducted with the Paspalum vaginatum (seashore paspalum) using different rates of biochar or compost addition to sandy loam soil and two water treatments (60% and 20% of the water-holding capacity of the control) during three seasons (winter, spring, and summer). Paspalum growth, physiological characteristics, and physicochemical properties of soil were investigated. The effect of biochar on soil properties was assessed using factor analysis of mixed data (FAMD). Additionally, multiple factorial designs (MFA) were used to examine the impact of three biochars on physiological functions. Peanut hull biochar application increased soil fertility and chlorophyll concentration of paspalum leaves significantly compared to the other biochars. Physiological characteristics were significantly improved with peanut hull biochar under summer compared to winter and spring due to the accumulation of nutrients in the soil by the decomposition of biochar. The application rate of the three biochars reduced the water requirements of paspalum. The best result was obtained by incorporating 6% peanut hull biochar into the soil, which resulted in better soil quality and healthy grass in dryland conditions while using 47.5% less water. These findings can be suitable for golf managers and can serve as a solution for dry zones.
Distribution Drivers of the Alien Butterfly Geranium Bronze (Cacyreus marshalli) in an Alpine Protected Area and Indications for an Effective Management
Authors: Rocchia Emanuel , Luppi Massimiliano , Paradiso Federica , Ghidotti Silvia , Martelli Francesca , Cerrato Cristiana , Viterbi Ramona , Bonelli Simona
Published: April 2022

Cacyreus marshalli is the only alien butterfly in Europe. It has recently spread in the Gran Paradiso National Park (GPNP), where it could potentially compete with native geranium-consuming butterflies. Our study aimed to (1) assess the main drivers of its distribution, (2) evaluate the potential species distribution in GPNP and (3) predict different scenarios to understand the impact of climate warming and the effect of possible mitigations. Considering different sampling designs (opportunistic and standardised) and different statistical approaches (MaxEnt and N-mixture models), we built up models predicting habitat suitability and egg abundance for the alien species, testing covariates as bioclimatic variables, food plant (Pelargonium spp.) distribution and land cover. A standardised approach resulted in more informative data collection due to the survey design adopted. Opportunistic data could be potentially informative but a major investment in citizen science projects would be needed. Both approaches showed that C. marshalli is associated with its host plant distribution and therefore confined in urban areas. Its expansion is controlled by cold temperatures which, even if the host plant is abundant, constrain the number of eggs. Rising temperatures could lead to an increase in the number of eggs laid, but the halving of Pelargonium spp. populations would mostly mitigate the trend, with a slight countertrend at high elevations.
Antiviral Cell Products against COVID-19: Learning Lessons from Previous Research in Anti-Infective Cell-Based Agents
Authors: Chikileva Irina , Shubina Irina , Burtseva Anzhelika-Mariia , Kirgizov Kirill , Stepanyan Nara , Varfolomeeva Svetlana , Kiselevskiy Mikhail
Published: April 2022

COVID-19 is a real challenge for the protective immunity. Some people do not respond to vaccination by acquiring an appropriate immunological memory. The risk groups for this particular infection such as the elderly and people with compromised immunity (cancer patients, pregnant women, etc.) have the most serious problems in developing an adequate immune response. Therefore, dendritic cell (DC) vaccines that are loaded ex vivo with SARS-CoV-2 antigens in the optimal conditions are promising for immunization. Lymphocyte effector cells with chimeric antigen receptor (CAR lymphocytes) are currently used mainly as anti-tumor treatment. Before 2020, few studies on the antiviral CAR lymphocytes were reported, but since the outbreak of SARS-CoV-2 the number of such studies has increased. The basis for CARs against SARS-CoV-2 were several virus-specific neutralizing monoclonal antibodies. We propose a similar, but basically novel and more universal approach. The extracellular domain of the immunoglobulin G receptors will be used as the CAR receptor domain. The specificity of the CAR will be determined by the antibodies, which it has bound. Therefore, such CAR lymphocytes are highly universal and have functional activity against any infectious agents that have protective antibodies binding to a foreign surface antigen on the infected cells.
Frequency of the Dopamine Receptor D3 (rs6280) vs. Opioid Receptor µ1 (rs1799971) Polymorphic Risk Alleles in Patients with Opioid Use Disorder: A Preponderance of Dopaminergic Mechanisms?
Authors: Gondré-Lewis Marjorie C. , Elman Igor , Alim Tanya , Chapman Edwin , Settles-Reaves Beverlyn , Galvao Carine , Gold Mark S. , Baron David , Kazmi Shan , Gardner Eliot , Gupta Ashim , Dennen Catherine , Blum Kenneth
Published: April 2022

While opioids are a powerful class of drugs that inhibit transmission of pain signals, their use is tarnished by the current epidemic of opioid use disorder (OUD) and overdose deaths. Notwithstanding published reports, there remain gaps in our knowledge of opioid receptor mechanisms and their role in opioid seeking behavior. Thus, novel insights into molecular, neurogenetic and neuropharmacological bases of OUD are needed. We propose that an addictive endophenotype may not be entirely specific to the drug of choice but rather may be generalizable to altered brain reward circuits impacting net mesocorticolimbic dopamine release. We suggest that genetic or epigenetic alterations across dopaminergic reward systems lead to uncontrollable self-administration of opioids and other drugs. For instance, diminished availability via knockout of dopamine D3 receptor (DRD3) increases vulnerability to opioids. Building upon this concept via the use of a sophisticated polymorphic risk analysis in a human cohort of chronic opioid users, we found evidence for a higher frequency of polymorphic DRD3 risk allele (rs6280) than opioid receptor µ1 (rs1799971). In conclusion, while opioidergic mechanisms are involved in OUD, dopamine-related receptors may have primary influence on opioid-seeking behavior in African Americans. These findings suggest OUD-targeted novel and improved neuropharmacological therapies may require focus on DRD3-mediated regulation of dopaminergic homeostasis.
Advance Nanomaterials for Biosensors
Authors: Pandey Sadanand
Published: April 2022

Nanotechnology has a significant impact on everything in our daily life [...]
A BIM-GIS-IoT-Based System for Excavated Soil Recycling
Authors: Huang Tong , Kou Shicong , Liu Deyou , Li Dawang , Xing Feng
Published: April 2022

The increasing excavated soil from construction projects has become a big problem in the sustainable development of megacities worldwide. Even though excavated soil management concerns are receiving increased attention, low rates of excavated soil recycling remain a barrier to the continuous improvement of the construction industry. Nowadays, Building Information Modeling (BIM) technology has gained popularity for construction and demolition (C&D) waste management purposes. However, few studies and cases of recycling excavated soil using BIM technology have been found. This paper gives a BIM-GIS-IoT-based excavated soil recycling system to effectively integrate BIM and Internet of Things (IoT) technologies into a geographic information system (GIS) to achieve scientific and reasonable recycling for excavated soil. The system mentioned above could collaboratively manage information from the government, developers, construction enterprises, transportation companies, and recycling facilities to meet the requirement for the specific communication, analysis, decision-making, and recycling plan preparation of the excavation project. In addition, it provides a systematic method and applies relevant information technology required to recycle the excavated soil effectively in the excavation project. The system is intended to provide a fundamental digital construction model for excavated soil recycling, regardless of whether it is invoked by the existing application software or a program tailored to the demands of a specific organization or stakeholders. It makes excellent use of the rich information stored in digital information models, may create a mapping to the input data required by the application, or automatically convert the basic model to facilitate the specific analysis. This system can not only serve as an excavation project simulation tool before construction, but also serve as a tool to recycle the excavated soil and cost evaluation. The developed model is applied via case studies within an excavation project. Different plans are described and compared in detail in several aspects of the schedule, revenue, and contract, finding that actual benefits will differ depending on the project’s limiting conditions. The result indicates ample opportunity for the advantages of the BIM-GIS-IoT-based excavated soil recycling system in the excavation project.
The Monetary and Non-Monetary Impacts of Prefabrication on Construction: The Effects of Product Modularity
Authors: Chauhan Krishna , Peltokorpi Antti , Lavikka Rita , Seppänen Olli
Published: April 2022

Prefabrication is rapidly increasing in construction, and previous research has identified various impacts of prefabrication on projects. Modular product architecture is a great enabler for prefabrication; however, practitioners would benefit from more explicit knowledge on the impacts of prefabricated product types with different levels of product modularity. This study investigates the connection between the modularity level and the monetary and non-monetary impacts of prefabricated products. First, the literature on prefabrication and modularity is used to form three propositions which are related to product modularity and the benefits of prefabrication. The level of modularity is considered with two dimensions: the proportion of modules and the module description detail. Second, four prefabricated products are analyzed to test the propositions. The analysis revealed that (1) the level of modularity adopted in the product is directly proportional to the benefits. More specifically, (2) a higher proportion of modules in a project product contributes to higher cost-benefits. On the other hand, (3) prefabricated products with highly detailed module descriptions seem to lead to higher non-monetary benefits, such as better ergonomics and work satisfaction. The study reveals new empirical evidence on the relationship between product modularity and the benefits of prefabricated products. Cost-benefit analysis revealed that even though some prefabricated products could have higher direct costs, the total cost can still be lower than conventional construction when also considering the indirect benefits. Practitioners can utilize the findings when selecting modular and prefabricated products that best fulfil their project objectives.
Cutting-Edge Platforms for Analysis of Immune Cells in the Hepatic Microenvironment—Focus on Tumor-Associated Macrophages in Hepatocellular Carcinoma
Authors: Millian Daniel E. , Saldarriaga Omar A. , Wanninger Timothy , Burks Jared K. , Rafati Yousef N. , Gosnell Joseph , Stevenson Heather L.
Published: April 2022

The role of tumor-associated macrophages (TAMs) in the pathogenesis of hepatocellular carcinoma (HCC) is poorly understood. Most studies rely on platforms that remove intrahepatic macrophages from the microenvironment prior to evaluation. Cell isolation causes activation and phenotypic changes that may not represent their actual biology and function in situ. State-of-the-art methods provides new strategies to study TAMs without losing the context of tissue architecture and spatial relationship with neighboring cells. These technologies, such as multispectral imaging (e.g., Vectra Polaris), mass cytometry by time-of-flight (e.g., Fluidigm CyTOF), cycling of fluorochromes (e.g., Akoya Biosciences CODEX/PhenoCycler-Fusion, Bruker Canopy, Lunaphore Comet, and CyCIF) and digital spatial profiling or transcriptomics (e.g., GeoMx or Visium, Vizgen Merscope) are being utilized to accurately assess the complex cellular network within the tissue microenvironment. In cancer research, these platforms enable characterization of immune cell phenotypes and expression of potential therapeutic targets, such as PDL-1 and CTLA-4. Newer spatial profiling platforms allow for detection of numerous protein targets, in combination with whole transcriptome analysis, in a single liver biopsy tissue section. Macrophages can also be specifically targeted and analyzed, enabling quantification of both protein and gene expression within specific cell phenotypes, including TAMs. This review describes the workflow of each platform, summarizes recent research using these approaches, and explains the advantages and limitations of each.
The Entanglement between Mitochondrial DNA and Tumor Metastasis
Authors: Wu Qiwei , Tsai Hsiang-i , Zhu Haitao , Wang Dongqing
Published: April 2022

Mitochondrial DNA, the genetic material in mitochondria, encodes essential oxidative phosphorylation proteins and plays an important role in mitochondrial respiration and energy transfer. With the development of genome sequencing and the emergence of novel in vivo modeling techniques, the role of mtDNA in cancer biology is gaining more attention. Abnormalities of mtDNA result in not only mitochondrial dysfunction of the the cancer cells and malignant behaviors, but regulation of the tumor microenvironment, which becomes more aggressive. Here, we review the recent progress in the regulation of cancer metastasis using mtDNA and the underlying mechanisms, which may identify opportunities for finding novel cancer prediction and therapeutic targets.
Magnesium-Modified Co3O4 Catalyst with Remarkable Performance for Toluene Low Temperature Deep Oxidation
Authors: Zigla Abraham Atour , Kox Tim , Mevoa Daniel , Assaouka Hypolite Todou , Nsangou Issah Njiawouo , Daawe Daniel Manhouli , Kenmoe Stephane , Kouotou Patrick Mountapmbeme
Published: April 2022

Co3O4, MgCo2O4 and MgO materials have been synthesized using a simple co-precipitation approach and systematically characterized. The total conversion of toluene to CO2 and H2O over spinel MgCo2O4 with wormlike morphology has been investigated. Compared with single metal oxides (Co3O4 and MgO), MgCo2O4 with the highest activity has exhibited almost 100% oxidation of toluene at 255 °C. The obtained results are analogous to typical precious metal supported catalysts. The activation energy of toluene over MgCo2O4 (38.5 kJ/mol) is found to be much lower than that of Co3O4 (68.9 kJ/mol) and MgO ((87.8 kJ/mol)). Compared with the single Co and Mg metal oxide, the as-prepared spinel MgCo2O4 exhibits a larger surface area, highest absorbed oxygen and more oxygen vacancies, thus highest mobility of oxygen species due to its good redox capability. Furthermore, the samples specific surface area, low-temperature reducibility and surface adsorbed oxygenated species ratio decreased as follows: MgCo2O4 > Co3O4 > MgO; which is completely in line with the catalytic performance trends and constitute the reasons for MgCo2O4 high excellent activity towards toluene total oxidation. The overall finding supported by ab initio molecular dynamics simulations of toluene oxidation on the Co3O4 and MgCo2O4 suggest that the catalytic process follows a Mars–van Krevelen mechanism.
Two-Step Dry Gel Method Produces MgAPO-11 with Low Aspect Ratio and Improved Catalytic Performance in the Conversion of Methanol to Hydrocarbons
Authors: Zhang Lina , Firth Daniel Sean , Olsbye Unni , Bao Xiaojun
Published: April 2022

In this article, the synthesis, characterization and catalytic performance of three MgAPO-11 catalysts with distinct crystal morphologies (sunflower, ball and candy) are presented. Among the three samples, the candy-like MgAPO-11-C, with high crystallinity and uniform particle size (of about 1 µm), was synthesized for the first time by using a unique two-step dry gel method. Despite the similar acid strength of the three samples, the different and distinct morphologies of the catalysts resulted in very different methanol-to-hydrocarbons (MTH) performances. In particular, the candy-like MgAPO-11-C presented the best MTH performance with the highest total conversion capacity (4.4 gMeOH·gcatalyst−1 h−1) and the best selectivity to C5+ aliphatics (64%).
Surgical Outcome of Children with a Malignant Liver Tumour in The Netherlands: A Retrospective Consecutive Cohort Study
Authors: Klunder Merel B. , Bruggink Janneke L. M. , Huynh Leon D. H. , Bodewes Frank A. J. A. , van der Steeg Alida F. W. , Kraal Kathelijne C. J. M. , van de Ven C. P. (Kees) , van Grotel Martine , Zsiros József , Wijnen Marc H. W. A. , Molenaar I. Q. (Quintus) , Porte Robert J. , de Meijer Vincent E. , de Kleine Ruben H.
Published: April 2022

Introduction: Six to eight children are diagnosed with a malignant liver tumour yearly in the Netherlands. The majority of these tumours are hepatoblastoma (HB) and hepatocellular carcinoma (HCC), for which radical resection, often in combination with chemotherapy, is the only curative treatment option. We investigated the surgical outcome of children with a malignant liver tumour in a consecutive cohort in the Netherlands. Methods: In this nationwide, retrospective observational study, all patients (age < 18 years) diagnosed with a malignant liver tumour, who underwent partial liver resection or orthotopic liver transplantation (OLT) between January 2014 and April 2021, were included. Children with a malignant liver tumour who were not eligible for surgery were excluded from the analysis. Data regarding tumour characteristics, diagnostics, treatment, complications and survival were collected. Outcomes included major complications (Clavien–Dindo ≥ 3a) within 90 days and disease-free survival. The results of the HB group were compared to those of a historical HB cohort. Results: Twenty-six children were analysed, of whom fourteen (54%) with HB (median age 21.5 months), ten (38%) with HCC (median age 140 months) and one with sarcoma and a CNSET. Thirteen children with HB (93%) and three children with HCC (30%) received neoadjuvant chemotherapy. Partial hepatic resection was possible in 19 patients (12 HB, 6 HCC, and 1 sarcoma), whilst 7 children required OLT (2 HB, 4 HCC, and 1 CNSET). Radical resection (R0, margin ≥ 1.0 mm) was obtained in 24 out of 26 patients, with recurrence only in the patient with CNSET. The mean follow-up was 39.7 months (HB 40 months, HCC 40 months). Major complications occurred in 9 out of 26 patients (35% in all, 4 of 14, 29% for HB). There was no 30- or 90-day mortality, with disease-free survival after surgery of 100% for HB and 80% for HCC, respectively. Results showed a tendency towards a better outcome compared to the historic cohort, but numbers were too small to reach significance. Conclusion: Survival after surgical treatment for malignant liver tumours in the Netherlands is excellent. Severe surgical complications arise in one-third of patients, but most resolve without long-term sequelae and have no impact on long-term survival.
Intercultural Differences in the Development of Pediatric Medical Traumatic Stress (PMTS) in Children Following Surgical Hospitalization
Authors: Masalha Bushra , Ben-David Shiri , Benarroch Fortu , Ben-ari Amichai
Published: April 2022

Background: Illness, surgery and surgical hospitalization are significant stressors for children. Some children who experience such a medical event may develop Pediatric Medical Traumatic Stress (PMTS). PMTS affects physical recovery, and many areas and functions in children’s lives, both short- and long-term. The aim of the study is to examine the difference in the rate of PMTS between the Arab and Jewish populations and the difference in risk factors for the development of this syndrome. Method: The study involved 252 parents of children aged 1–6 who were hospitalized in the surgical ward of Hadassah Medical Center. During hospitalization, parents completed questionnaires to identify risk factors for the development of PMTS. At 3 months from the time of discharge, the children’s level of PMTS was measured. Results: The rate of children diagnosed with PMTS among Arab children was significantly higher than the rate in the Jewish population. The affiliation to an ethnic group affected different socioeconomic, demographic, social, linguistic and cultural background variables, which in turn affected the emergence of PMTS. Conclusion: The study emphasizes the nature of PMTS at the intercultural level, which can be an important source for theoretically understanding both the disorder and culture, as well as for clinical implications in developing population-sensitive treatment.
Simulation of Resonant Cavity-Coupled Colloidal Quantum-Dot Detectors with Polarization Sensitivity
Authors: Zhao Pengfei , Mu Ge , Chen Menglu , Tang Xin
Published: April 2022

Infrared detectors with polarization sensitivity could extend the information dimension of the detected signals and improve target recognition ability. However, traditional infrared polarization detectors with epitaxial semiconductors usually suffer from low extinction ratio, complexity in structure and high cost. Here, we report a simulation study of colloidal quantum dot (CQD) infrared detectors with monolithically integrated metal wire-grid polarizer and optical cavity. The solution processibility of CQDs enables the direct integration of metallic wire-grid polarizers with CQD films. The polarization selectivity of HgTe CQDs with resonant cavity-enhanced wire-grid polarizers are studied in both short-wave and mid-wave infrared region. The extinction ratio in short-wave and mid-wave region can reach up to 40 and 60 dB, respectively. Besides high extinction ratio, the optical cavity enhanced wire-grid polarizer could also significantly improve light absorption at resonant wavelength by a factor of 1.5, which leads to higher quantum efficiency and better spectral selectivity. We believe that coupling CQD infrared detector with wire-grid polarizer and optical cavity can become a promising way to realize high-performance infrared optoelectronic devices.
Geopolymer Concrete: A Material for Sustainable Development in Indian Construction Industries
Authors: Verma Manvendra , Dev Nirendra , Rahman Ibadur , Nigam Mayank , Ahmed Mohd. , Mallick Javed
Published: April 2022

Geopolymer concrete (GPC) is a new material in the construction industry, with different chemical compositions and reactions involved in a binding material. The pozzolanic materials (industrial waste like fly ash, ground granulated blast furnace slag (GGBFS), and rice husk ash), which contain high silica and alumina, work as binding materials in the mix. Geopolymer concrete is economical, low energy consumption, thermally stable, easily workable, eco-friendly, cementless, and durable. GPC reduces carbon footprints by using industrial solid waste like slag, fly ash, and rice husk ash. Around one tonne of carbon dioxide emissions produced one tonne of cement that directly polluted the environment and increased the world’s temperature by increasing greenhouse gas production. For sustainable construction, GPC reduces the use of cement and finds the alternative of cement for the material’s binding property. So, the geopolymer concrete is an alternative to Portland cement concrete and it is a potential material having large commercial value and for sustainable development in Indian construction industries. The comprehensive survey of the literature shows that geopolymer concrete is a perfect alternative to Portland cement concrete because it has better physical, mechanical, and durable properties. Geopolymer concrete is highly resistant to acid, sulphate, and salt attack. Geopolymer concrete plays a vital role in the construction industry through its use in bridge construction, high-rise buildings, highways, tunnels, dams, and hydraulic structures, because of its high performance. It can be concluded from the review that sustainable development is achieved by employing geopolymers in Indian construction industries, because it results in lower CO2 emissions, optimum utilization of natural resources, utilization of waste materials, is more cost-effective in long life infrastructure construction, and, socially, in financial benefits and employment generation.
Randomized Controlled Trials in Lung, Gastrointestinal, and Breast Cancers: An Overview of Global Research Activity
Authors: Wells J. Connor , Fundytus Adam , Sharma Shubham , Hopman Wilma M. , Del Paggio Joseph C. , Gyawali Bishal , Mukherji Deborah , Hammad Nazik , Pramesh C. S. , Aggarwal Ajay , Sullivan Richard , Booth Christopher M.
Published: April 2022

Background: In this study, we compared and contrasted design characteristics, results, and publications of randomized controlled trials (RCTs) in gastrointestinal (GI), lung, and breast cancer. Methods: A PUBMED search identified phase III RCTs of anticancer therapy in GI, lung, and breast cancer published globally during the period 2014–2017. Descriptive statistics, chi-square tests, and the Kruskal–Wallis test were used to compare RCT design, results, and output across the cancer sites. Results: A total of 352 RCTs were conducted on GI (36%), lung (29%), and breast (35%) cancer. Surrogate endpoints were used in 55% of trials; this was most common in breast trials (72%) compared to GI (47%) and lung trials (43%, p < 0.001). Breast trials more often met their primary endpoint (54%) than GI (41%) and lung trials (41%) (p = 0.024). When graded with the ESMO-MCBS, lung cancer trials (50%, 15/30) were more likely to meet the threshold for substantial benefit. GI trials were published in journals with a substantially lower impact factor (IF; median IF 13) than lung (median IF 21) and breast cancer trials (median IF 21) (p = 0.038). Conclusions: Important differences in RCT design and output exist between the three major cancer sites. Use of surrogate endpoints and the magnitude of benefit associated with new treatments vary substantially across cancer sites.
Patient Perception When Transitioning from Classic to Remote Assisted Cardiac Rehabilitation
Authors: Busnatu Ștefan-Sebastian , Pană Maria-Alexandra , Lăcraru Andreea Elena , Jercălău Cosmina-Elena , Paun Nicolae , Caprino Massimo , Gand Kai , Schlieter Hannes , Kyriazakos Sofoklis , Andrei Cătălina Liliana , Sinescu Crina-Julieta
Published: April 2022

Cardiac rehabilitation is an individualized outpatient program of physical exercises and medical education designed to accelerate recovery and improve health status in heart disease patients. In this study, we aimed for assessment of patients’ perception of the involvement of technology and remote monitoring devices in cardiac recovery. During the Living Lab Phase of the Virtual Coaching Activities for Rehabilitation in Elderly (vCare) project, we evaluated eleven patients (five heart failure patients and six ischemic heart disease patients). Patient admission in the UMFCD cardiology clinical department served as a shared inclusion criterion for both study groups. In addition, the presence of II or III heart failure NYHA stage status was considered an inclusion criterion for the heart failure study group and patients diagnosed with ischemic heart disease for the second one. We conducted a system usability survey to assess the patients’ perception of the system’s technical and medical functions. The survey had excellent preliminary results in the heart failure study group and good results in the ischemic heart disease group. The limited access of patients to cardiac rehabilitation in Romania has led to increased interest and motivation in this study. The final version of the product is designed to adapt to patient needs and necessities; therefore, patient perception is necessary.
Dual-Layer Inductor Active Equalization Control for Series-Connected Lithium-Ion Batteries Based on SOC Estimation
Authors: Liu Xiaofei , Pang Hui , Geng Yuanfei
Published: April 2022

In order to reduce the time and improve the balancing speed of traditional single-layer inductive equalization circuits, this paper proposes an active equalization control strategy with double-layer inductors for series-connected battery packs, based on an accurate state-of-charge (SOC) estimation. By selecting the inductor as the intermediate energy storage element, the SOC of the single lithium-ion battery (LIB) cell is calculated by using a particle filter (PF) algorithm. Meanwhile, according to the deviation in SOC among the batteries, stop parameters are introduced to achieve the design and optimization of the equalization strategy. Finally, the relationship between the equalization current and the control signal period is derived to fulfill the equalization. The experimental results show that, compared with the traditional single-layer inductive equalization topology, the proposed equalization control topology can shorten the equalization time by at least 15.6%. More importantly, this equalization scheme overcomes the disadvantage of the long energy transfer path of traditional inductive equalization, which helps to improve the equalization speed and the inconsistency of the battery pack.
Velocity-Free Formation Control and Collision Avoidance for UUVs via RBF: A High-Gain Approach
Authors: Yan Zheping , Jiang Anzuo , Lai Chonglang , Li Heng
Published: April 2022

This paper designs an adaptive formation control system for unmanned underwater vehicles (UUVs) in the presence of unmeasurable states and environmental disturbance. To solve the problem of unmeasurable UUV states, a filtered high-gain observer (FHGO) is employed to estimate the states, despite measurement noise. Then, an adaptive control scheme is designed to achieve UUV formation collision avoidance. The radial basis function (RBF) is used to estimate the unknown disturbance. The stability of UUV formation with collision avoidance is proven by using the Lyapunov theorem. Numerical simulation is carried out to demonstrate that the proposed filtered high-gain observer is successful in estimating the states of UUVs. The control law can keep the UUV formation from collision with good performance.
Increasing EMI Immunity and Linearity of a CMOS 180 nm Voltage-to-Delay Converter
Authors: Richelli Anna , Colalongo Luigi , Bosio Federico Angelo
Published: April 2022

This paper presents a voltage-controlled delay unit (VCDU) with a novel architecture allowing for a wide input range of linearity and an improved immunity to electromagnetic interferences. The circuit is based on a current-starved inverter with a biasing technique to extend the input voltage range of linearity near to the rail-to-rail linearity range. The proposed scheme was designed by UMC 180 nm standard CMOS process and works without power-hungry amplifiers or comparators. It has a voltage supply of 1.8 V and exhibits a rail-to-rail linearity range (0–1.8 V) with an average EMI-induced jitter of only 1% of the nominal delay.
Combining Shift to Biogas Production in a Large WWTP in China with Optimisation of Nitrogen Removal
Authors: Vergara-Araya Mónica , Hilgenfeldt Verena , Steinmetz Heidrun , Wiese Jürgen
Published: April 2022

Despite the huge current challenges in sewage sludge treatment and disposal in China, anaerobic sludge stabilisation (AnSS) is still not a state-of-the-art process in WWTP in the country. However, the potential benefits of anaerobic sludge stabilisation may outweigh the drawbacks. One of these drawbacks is the backload from the sludge liquor that increases the nutrient load in the biological treatment stage. This work shows via computer modelling that not only can the sludge production and disposal costs be significantly reduced, but also that, with sensible automation and operational strategies (e.g., bypass of primary clarifiers, use of a centrate dosing strategy, incorporation of ammonium nitrogen sensors, etc.), the effects of the backload can be counteracted for nitrogen removal, even considering that wastewater in China often has an unfavourable C/N ratio for nitrogen removal. The tested strategies would even improve the overall plant performance in terms of norm compliance, sludge production, energy use, and energy production
Energy Management in the Multi-Source Systems
Authors: Baqar Awab , Camara Mamadou Baïlo , Dakyo Brayima
Published: April 2022

With the goals set for sustainable development and renewable energy technologies, major advancements have been observed in the domain of multi-source systems [...]
The Transmission of Intergenerational Epigenetic Information by Sperm microRNAs
Authors: Lee Grace S. , Conine Colin C.
Published: April 2022

Epigenetic information is transmitted from one generation to the next, modulating the phenotype of offspring non-genetically in organisms ranging from plants to mammals. For intergenerational non-genetic inheritance to occur, epigenetic information must accumulate in germ cells. The three main carriers of epigenetic information—histone post-translational modifications, DNA modifications, and RNAs—all exhibit dynamic patterns of regulation during germ cell development. For example, histone modifications and DNA methylation are extensively reprogrammed and often eliminated during germ cell maturation and after fertilization during embryogenesis. Consequently, much attention has been given to RNAs, specifically small regulatory RNAs, as carriers of inherited epigenetic information. In this review, we discuss examples in which microRNAs have been implicated as key players in transmitting paternal epigenetic information intergenerationally.
Changes in Myosin from Silver Carp (Hypophthalmichthys molitrix) under Microwave-Assisted Water Bath Heating on a Multiscale
Authors: Cong Haihua , Lyu He , Liang Wenwen , Zhang Ziwei , Chen Xiaodong
Published: April 2022

To further prove the advantages of microwave-assisted water bath heating (MWH) in low-value fish processing, the effects of different heating methods (two heating stage method, high temperature section respectively using MWH1, MWH2, MWH3, WH—water heating, MH—microwave heating) on secondary and tertiary myosin structures, SDS-PAGE, surface morphology, scanning electron microscopy (SEM), and particle size distribution were compared and analyzed. The findings revealed that MH and MWH aided in the production of gel formations by promoting myosin aggregation. Myosin from silver carps demonstrated enhanced sulfhydryl group and surface hydrophobicity after MWH treatment, as well as a dense network structure. The distribution of micropores becomes more uniform when the microwave time is increased. Actually, the total effect of microwave time on myosin is not substantially different. The correlation between particle size distribution and protein aggregation was also studied, in terms of time savings, the MWH of short microwave action is preferable since it not only promotes myosin aggregation but also avoids the drawbacks of a rapid warming rate. These discoveries give a theoretical foundation for understanding silver carp myosin under microwave modification, which is critical in the food industry.
Meat Quality Parameters, Sensory Properties and Consumer Acceptance of Chicken Meat from Dual-Purpose Crossbreeds Fed with Regional Faba Beans
Authors: Escobedo del Bosque Cynthia I. , Grahl Stephanie , Nolte Tanja , Mörlein Daniel
Published: April 2022

Consumers’ concerns regarding the ethical and environmental practices of the current poultry production system have led to the search for an alternative production method. This study evaluated samples of three dual-purpose chicken crossbreeds: Vorwerkhuhn × Bresse Gauloise (VBG), Vorwerkhuhn × White Rock (VWR), and Bresse Gauloise × White Rock (BWR), fed with two variants of faba beans (vicin/convicin-rich and -poor: VC+ and VC−, respectively) and soybeans to examine whether the FB-based diets affected the meat quality of the crossbreeds. pH, color, water holding capacity, tenderness, nucleotide content and proximal composition were analyzed instrumentally, whereas sensory properties were identified by a trained panel and product acceptance was evaluated by frequent chicken consumers. Results showed that from instrumental measurements, the yellowness of the samples was affected by the type of feedstuff, whereas most other parameters were affected by the crossbreed, particularly color and nucleotide content. Sensory attributes, specifically, overall chicken aroma as well as firmness and crumbliness, were affected by an interaction of the feedstuff and crossbreed. Consumer preference did not show significant differences between samples. Overall, a faba-bean-based diet appeared to be a suitable alternative to a soybean-based diet on the crossbreeds VBG, VWR, and BWR when assessing the overall quality and taste of chicken breasts.
The Formation of the North Qilian Shan through Time: Clues from Detrital Zircon Fission-Track Data from Modern River Sediments
Authors: Lin Xu , Jolivet Marc , Liu-Zeng Jing , Cheng Feng , Wu Zhonghai , Tian Yuntao , Li Lingling , Chen Jixin
Published: April 2022

Understanding the formation of the North Qilian Shan in the NE Tibetan Plateau provides insights into the growth mechanisms of the northern region of the plateau across time. Detrital zircon fission-track (ZFT) analyses of river sediments can provide a comprehensive understanding of the exhumation history during prolonged orogenesis. Here, we applied the detrital thermochronology approach to the Qilian Shan orogenic belt. This work presents the first single-grain detrital ZFT data from river-bed sediments of the upper Hei River catchment in North Qilian Shan. The single ZFT ages are widely distributed between about 1200 Ma and about 40 Ma. These data record the protracted history of the Qilian Shan region from the Neoproterozoic evolution of Rodinia and late Paleozoic amalgamation of Central Asia to the accretion of the Gondwanian blocks during the Meso-Cenozoic era. Strong post-magmatic cooling events occurred in North Qilian Shan at 1200~1000 Ma, corresponding to the assembly of the Rodinia supercontinent. The age population at 800 Ma documents the oceanic spreading in the late Neoproterozoic dismantling of Rodinia. ZFT ages ranging from about 750 Ma to 550 Ma (with age peaks at 723 Ma and 588 Ma) are consistent with the timing of the opening and spreading of the Qilian Ocean. The age peaks at 523 Ma and 450 Ma mark the progressive closure of that ocean ending with the collision of the Qilian block with the Alxa block—North China craton in the Devonian. The Qilian Ocean finally closed in Late Devonian (age peak at 375 Ma). In the late Paleozoic (275 Ma), the subduction of the Paleotethys Ocean led to extensive magmatic activity in the North Qilian Shan. During the Lower Cretaceous (145 Ma), the accretion of the Lhasa block to the south (and potentially the closure of the Mongol-Okhotsk Ocean to the northeast) triggered a renewed tectonic activity in the Qilian Shan. Finally, a poorly defined early Eocene exhumation event (50 Ma) suggests that the NE Tibetan Plateau started to deform nearly synchronously with the onset of the India-Asia collision. This study demonstrates the usefulness of combining modern-river detrital thermo-/geochronological ages and bedrock geochronological ages to understand large-scale orogenic evolution processes.
Ovarian Endometrioid and Clear Cell Carcinomas with Low Prevalence of Microsatellite Instability: A Unique Subset of Ovarian Carcinomas Could Benefit from Combination Therapy with Immune Checkpoint Inhibitors and Other Anticancer Agents
Authors: Nonomura Yuki , Nakayama Kentaro , Nakamura Kohei , Razia Sultana , Yamashita Hitomi , Ishibashi Tomoka , Ishikawa Masako , Sato Seiya , Nakayama Satoru , Otsuki Yoshiro , Kyo Satoru
Published: April 2022

Ovarian cancer has the highest mortality rate among all gynecological malignancies; therefore, a novel treatment strategy is needed urgently. Utilizing immune checkpoint inhibitors has been considered for microsatellite instability (MSI)-high (MSI-H) tumors. However, the prevalence of MSI-H tumors in ovarian endometrioid and clear cell carcinomas remains unclear. Here, polymerase chain reaction was used to analyze 91 cases of ovarian endometrioid and clear cell carcinomas for the MSI status and the relationship between MSI-H, immune checkpoint molecules, and clinicopathological factors (including patient survival). Only 5 of 91 (5%) cases were MSI-H endometrioid carcinomas. In these cases, CD-8 expression was significantly higher (p = 0.026), confirming an enhanced immune response. From the survival curve, no statistical correlations were found between the MSI-H group and the microsatellite stable (MSS) group; however, the MSS group trended towards better progression-free survival than the MSI-H group (p = 0.056). Patients with PD-L1 expression had shorter overall survival than those without (p = 0.022). Thus, MSI-H is a rare event and not a favorable prognostic factor in ovarian endometrioid and clear cell carcinomas. Thus, to improve the prognosis of ovarian endometrioid carcinoma and clear cell carcinomas, a combination therapy of immune checkpoint inhibitors and other molecular targeted therapies may be required.