bluuebunny/crossref_metadata_2025 huggingface dataset:
Bal elülső leszállóágból eredő jobb koszorúér, avagy kettős lokalizációjú STEMI egy csavarral
Authors: Gergely Gábor , Szabó Zsolt István , Körömi Zsolt , Petrov Csaba
Published: December 2024

Esetismertetésünkben egy akut koronáriaszindróma kapcsán mellékleletként talált koszorúér-fejlődési rendellenesség bemutatását és ismeretének fontosságát részletezzük. Az egyébként strukturálisan ép szív koronáriaanomáliái ritka entitások, amelyek ismerete a gyakorló kardiológusok számára is szükséges, különös tekintettel a koronáriaintervenciót végzők körében. Az úgynevezett single coronary artery esetében – ahogy a neve is utal rá – a teljes koszorúérrendszer egyetlen közös törzzsel ered. Egyik gyakoribb változata, amikor a főtörzs a bal Valsalva-tasakból, a jobb koszorúér pedig a bal elülső leszállóág proximális vagy mediális szakaszából ered. Ilyen anatómiai viszonyok mellett a tervezett intervenciós stratégia megválasztása kiemelt jelentőségű, mivel akut koronáriaszindróma vagy intervenciós komplikáció esetén potenciálisan nagyobb szívizomterület sérülhet.
P2MAT: A machine learning (ML) driven software for Property Prediction of MATerial
Authors: Kamruzzaman Methun , Landera Alexander , Menon Nalini Chulliyil , Allendorf Mark D. , Poorey Kunal
Published: December 2024

Accurate prediction of melting points for pure molecules remains a significant challenge in predictive chemistry, with implications across various scientific fields, including materials science, drug discovery, and separations chemistry. Traditional methods, such as group contribution (GC) techniques, have shown limited success due to the complex relationship between molecular structure and melting point. In this study, we present a data-driven machine learning (ML) approach to predict the melting points of organic compounds, leveraging both 2D and 3D molecular descriptors. Our dataset comprises 19,811 compounds with 2D features and a subset of 4,568 compounds with additional 3D features. We employed feature selection methods, including pair-wise correlation, Boruta, and principal component analysis, to refine our feature set. Various ML models, including linear regression, ensemble-based regression (Random Forest, gradient- boosted regression, Extreme gradient-boosted regression), support vector regression, and deep learning, were evaluated for their predictive performance. The Extreme Gradient Boosted Regression (XGBR) model demonstrated superior performance with a mean absolute error (MAE) of 27.64 K for 2D features and 31.58 K for combined 2D and 3D features. Outlier detection and removal further improved model accuracy. Additionally, SHAP (SHapley Additive exPlanations) analysis provided insights into feature importance, enhancing model interpretability. Our results indicate that ML models, particularly XGBR, can significantly improve melting point predictions, offering a robust tool for the scientific community. Scientific Contribution: The P2MAT application capable to predict both melting point and boiling point from SMILEs string as inputs. The GUI is simple and easy to load in the system.
Compositional flexibility in irreducible antifluorite electrolytes for next-generation battery anodes
Authors: Landgraf Victor , Tu Mengfu , Cheng Zhu , Vasileiadis Alexandros , Wagemaker Marnix , Famprikis Theodosios
Published: December 2024

Solid state batteries currently receive ample attention due to their potential to outperform lithium ion batteries in terms of energy density when featuring next generation anodes such as lithium metal or silicon. One key remaining challenge is identifying solid electrolytes that combine high ionic conductivity with stability in contact with the highly reducing potentials of next-generation anodes. Fully reduced electrolytes, based on irreducible anions, offer a promising solution by avoiding electrolyte decomposition altogether. In this study, we demonstrate the compositional flexibility of the disordered antifluorite framework accessible by mechanochemical synthesis and leverage it to discover irreducible electrolytes with high ionic conductivities. We show that the recently investigated Li9N2Cl3 and Li5NCl2 phases are part of the same solid solution of Li-deficient antifluorite phases existing on the LiCl-Li3N tie line with a general chemical formula of Li1+2xCl1-xNx (0.33
Brilliantly red: the structure of carmine
Authors: Svensson Grape Erik , Willhammar Tom , Inge A. Ken
Published: December 2024

Carmine is a red pigment made from dried cochineal, a scale insect that has been a source of brilliant scarlet reds in clothing and art for more than two millennia, with records dating back to 700 BC. Since the 16th century, it has been intensely traded all over the world and was one of the most important trade goods for the Spanish empire at its economic peak. Despite still being used on an industrial scale, with hundreds of metric tonnes produced annually, the exact molecular and crystal structure of the dyestuff remains undetermined. Notably, both modern-day commercial carmine and pigments prepared following historical recipes show strikingly similar diffraction patterns, indicating a common crystalline structure. Several model structures of carmine have been proposed, and so far spectroscopic measurements have hinted at a tetrameric complex containing the conjugate base of carminic acid, aluminium ions, and calcium ions. Considering its commercial and historical significance, determining the structure and composition of carmine would aid in both modern-day regulation and identification in historical samples. Here we show that the crystal structure of carmine can at last be determined using three-dimensional electron diffraction measurements. Our investigation reveals that carmine is indeed comprised of a tetrameric complex, that assembles into a nanoporous supramolecular structure with pore diameters of approximately 1.8 nm, held together by intermolecular hydrogen bonding. Our results establish a definite structure of carmine, unveiling a surprisingly complicated arrangement in a product that has been traded around the world for centuries. We anticipate that this study will prompt further investigations of age-old crystalline compounds and formulations using state-of-the-art electron crystallography methods, while also highlighting the serendipitous creation of a man-made supramolecular material that dates back thousands of years.
Presumptive Tests for Xylazine – A Computer Vision Approach
Authors: Chang Hui Yun , Donnachie Kristin , McCabe Timothy J.D. , Barrington Henry , Ceniccola-Campos Kristin , Carlysle-Davies Felicity , Reid Marc
Published: December 2024

Abuse of xylazine is an immediate global public health concern. We report the distinct and measurable colour changes when xylazine is exposed to the Mandelin, Marquis, and Mecke presumptive test reagents. The colour changes observed with xylazine are distinct from those of drugs that give colour changes from the same presumptive tests. Using single image and video analyses, distinctive features of presumptive tests with xylazine help differentiate it from other illicit substances tested under the same conditions, including morphine, fentanyl, heroin, and methamphetamine. Herein, experimental protocols utilising Kineticolor, a computer vision software, were developed to qualitatively and quantitatively study presumptive tests for xylazine detection. To the best of our knowledge, these findings represent the first presumptive test strategy towards specific, quantifiable, and potentially field-ready detection of xylazine.
Synthesis and Structural Insights into Homoleptic and Heteroleptic Cationic Germylene Gold(I) Complexes
Authors: Wu Lifang , Zhang Rong , Wang Xinran , Zeng Wenyao , Zhang Lanhui , Gao Yining , Li Mengyang , Liu Jiyong , Kong Lingbing , Wang Liliang
Published: December 2024

Novel homoleptic and heteroleptic cationic germylene-gold(I) complexes were synthesized through the insertion of dialkyl- and acyclic diamino- germylenes into Au-Cl bonds. Structural characterization and DFT calculations revealed the distinct π-back donation and dihedral angles, providing quantitative insights into the stability of germylene ligands in gold(I) complexes and expanding the boundaries of coordination chemistry.
Quantum Coulombic Interactions Mediate Free Radical Control in Radical SAM Viperin/RSAD2
Authors: Khalilian M. Hossein , DiLabio Gino
Published: December 2024

There are thousands of radical S-adenosylmethionine (rSAM) enzymes capable of catalyzing over 80 distinct reactions, yet their use in biotechnological applications is limited, primarily due to a lack of understanding of how these enzymes control highly reactive radical intermediates. Here, we show that little-known quantum Coulombic interactions are, in part, responsible for free radical control in Viperin/RSAD2, one of the few radical SAM enzymes expressed in humans. Using molecular dynamics and high-level multi-state broken-symmetry quantum mechanical/molecular mechanics calculations, we elucidated the mechanistic details of the catalysis, identifying a key step characterized by the formation of an unprecedented metastable deprotonated ribose radical intermediate. This intermediate is thermodynamically stabilized by spin-charge exchange-correlation interactions—a quantum Coulombic effect. The magnitude of this stabilization is such that the radical displays acidity two to six pKa units lower than that of closed-shell ribose. Given the omnipresence of negative charges in biological systems, these interactions potentially represent a universal mechanism for stabilizing and controlling highly reactive radical intermediates across radical enzymes, opening new avenues for enzymatic engineering and biotechnological applications.
Power strokes in molecular motors: Predictive, irrelevant, or somewhere in between?
Authors: Penocchio Emanuele , Gu Geyao , Albaugh Alex , Gingrich Todd R.
Published: December 2024

For several decades, molecular motor directionality has been rationalized in terms of the free energy of molecular conformations visited before and after the motor takes a step, a so-called power stroke mechanism with analogues in macroscopic engines. Despite theoretical and experimental demonstrations of its flaws, the power stroke language is quite ingrained, and some communities still value power stroke intuition. By building a catalysis-driven motor into simulated numerical experiments, we here systematically report on how directionality responds when the motor is modified accordingly to power stroke intuition. We confirm that the power stroke mechanism generally does not predict motor directionality. Nevertheless, the simulations illustrate that the relative stability of molecular conformations should be included as a potential design element to adjust the motor directional bias. Though power strokes are formally unimportant for determining directionality, we show that practical attempts to alter a power stroke have side effects that can in fact alter the bias. The change in the bias can align with what power stroke intuition would have suggested, offering a potential explanation for why the flawed power stroke mechanism can retain apparent utility when engineering specific systems.
Fast and Effective Preparation of Highly Cytotoxic Hybrid Molecules of Schweinfurthin E and OSW-1
Authors: Schelle Baptiste , Fargier Jules , Grisel Clément , Askenatzis Laurie , Gallard Jean-François , Desrat Sandy , Bignon Jérome , Roussi Fanny , Norsikian Stephanie
Published: December 2024

Herein, we present the first synthesis of hybrid molecules combining the pharmacophores of two natural compounds, schweinfurthin E (SW-E) and the glycosidic moiety of OSW-1. These hybrids were designed leveraging the complementary binding of SW-E and OSW-1 to their biological target. The synthetic process highlights, in particular, one-pot functionalization and glycosylation of an L-arabinose unit using a D-xyloside donor and a CuAAC click reaction involving a polyfunctionalized prenylated stilbene derived from SW-E. The cytotoxicity of the four SW-E and OSW-1 hybrids is also reported, two of them being much more cytotoxic than SW-E on a glioblastoma cancer cell line. Finally, a molecular modeling study is conducted to rationalize the biological results obtained.
Nadbałtyckie, połabskie i pomorskie uzupełnienia do prac o jeniectwie w średniowieczu (część pierwsza)
Authors: Smoliński Marek
Published: December 2024

Polish historical literature has recently seen a renewed interest in the fate of prisoners of war who fell into captivity in the numerous battles fought during the Middle Ages. Due to the availability of historical sources, particular attention has been paid to the fourteenth and fifteenth centuries, although, of course, relatively few examples of captives from the earlier period have been discussed. In this respect, chronicles illustrating armed conflicts between the Polish or Polish­ Lithuanian state and the Teutonic Order have been particularly useful. What came as an important point of reference for historians were also cases of prisoners of war described in Western European sources. So far, there has been no broader study of medieval captives which would focus on the Slavia. This term first referred to the territories inhabited by the Polabian Slavs, from Holstein to the borders of Western Pomerania. At the end of the twelfth and in the thirteenth century, it came to be used for medieval Mecklenburg and Western Pomerania. From the perspective of the Kingdom of Denmark, it was still a much wider area. The present study attempts to trace and discuss cases of captivity in the geographical area in question.
The work covers mainly the years 1177–1320, from the conflict over the Saxon inheritance after the death of Henry the Lion, in which not only German, but also Mecklenburg and Pomeranian rulers took part, to the extinction of the Brandenburg margraves from the Ascanian dynasty. War or conflict was an important tool of the policy of members of this dynasty, particularly experienced by other feudal lords from the area under study.
Considering that the source material is quite extensive, for editorial reasons the study has been divided into parts. The first part covers the period until the end of the twelfth century.
Czy Agata, żona anglosaskiego księcia Edwarda Wygnańca, mogła być córką Mieszka II?
Authors: Szerle Jędrzej
Published: December 2024

One of the mysteries in the history of eleventh-century England is the origin of Agatha, the wife of the Anglo-Saxon prince Edward the Exile. After the death of his father – Edmund Ironside – in 1016, he and his brother Edmund were expelled from England by Canute the Great. Edward probably first stayed in Sweden and Rus’, and then settled in Hungary; in the meantime, his brother died. While in exile, he married Agatha, with whom he had three children: Margaret, Cristina and Edgar Aetheling. In 1057, Edward returned to England, where he soon died. His children played a significant role in history. Edgar Aetheling fought against William the Conqueror after the Battle of Hastings in 1066. Margaret became the wife of King of Scotland, and their daughter Matilda married King of England in 1100.
Due to imprecise and relatively late information in sources, there are many hypotheses regarding Agatha’s ancestors. According to the most popular ones, she was of imperial, Rus’ or Hungarian descent. A different hypothesis suggests that she came from the Piast dynasty – she was the daughter of and Richeza. However, all the hypotheses have considerable gaps that make them difficult to accept.
We believe that Agatha was of high birth but did not come from the main branch of a ruling family or was an illegitimate child, and the source references to her imperial or royal descent are a political legend created at the court of her granddaughter Matilda, wife of King of England. It seems probable that she came from Rus’.
Kilka uwag na temat obrazu „idealnego władcy” Teodoryka Wielkiego w świetle „Variae” Kasjodora Senatora (część druga)
Authors: Wojcieszak Maciej
Published: December 2024

This is the second part of an article analysing letters from the royal chancellery of Theodoric the Great in terms of creating an image of an “ideal” Christian ruler on the example of Theodoric. Following a brief introduction (background information appears in the first part), we discuss the next three features of an “ideal” ruler emerging from the sources: engagement in military affairs, skilful conduct of foreign affairs, Christian virtues and care for the Church. This part of the article also includes conclusions about the image of an “ideal” Christian ruler presented on the example of Theodoric.
Characterization of Datuk Maringgih In the Script Siti Nurbaya: Wajah Di Sebalik Punggung Written by Edy Suisno
Authors: Ardafi Yudhistino , Barkah Hendri Jihadul , Susanti Desi
Published: December 2024

Siti Nurbaya: Wajah di Sebalik Punggung, written by Edy Suisno, focuses on the character Datuk Maringgih. In the novel Siti Nurbaya by Marah Roesli, Datuk Maringgih is known as a cruel and greedy man. Datuk Maringgih is a rich old merchant who is considered evil because he married Siti Nurbaya as a debt to all of Siti Nurbaya's family debts. At first glance, Datuak Maringgih's actions look evil and detrimental to Siti Nurbaya. If you pay closer attention, taking into account the traditional aspects regarding the role of the Niniak Mamak in Minangkabau, as stated in the saying "anak dipangku, kamanakan dibimbiang", that a mamak has obligations and takes part in the life of his nephew. Analyze Datuk Maringgih's characterization, and look at three aspects of Lajos Egri, namely physiological, sociological, and psychological. The performance of the script Siti Nurbaya: The Face Behind the Back is realized in the form of a musical drama. According to Joe Deer, a musical drama is a drama performance where the actors who act as characters on stage are required to be able to depict the atmosphere of the story being played using singing and dancing as a medium of expression. A good actor is not only an actor who is good at acting on stage but also has to be proficient with matters related to musicality and choreography. It is not an easy matter to bring a character to life on stage as a musical drama actor. The actor is not only required to act when the performance starts until it ends but also has to master the acting and choreography related to the storyline at the same time.
Application Of Dramatic Elements In Theatre Performances In The 2023 Sunda Language Drama Festival
Authors: Precillia Monita
Published: December 2024

The research entitled Application Of Dramatic Elements In Theatre Performances In The 2023 Sunda Language Drama Festival uses qualitative research methods: observation, interviews, documentation, and data analysis. This research discusses how Sunda plays a role in building the dramatic elements of theater performances. The issue of the diminishing existence of regional languages is one of the factors in the formation of the Sunda Language Drama Festival. The Sunda Language Drama Festival does not focus on the application of Sunda dialectics but on the form of performance, so that Sunda only becomes a language in communication. these conditions are certainly not effective if the purpose of the Sunda Language Drama Festival is an effort to maintain Sunda. The phenomenon of shifting language use and forms of regional language preservation is an urgency to study at this time, one example is the Sunda Language Drama Festival. This paper aims to analyze the effect of Sunda dialogue on the dramatic structure of the performance.
Fantasia Andung Ni Si Boruadi ; Perwujudan Tradisi Andung Batak Toba Ke dalam Komposisi Musik Bentuk Fantasia Tiga Bagian (Fantasia Andung Ni Si Boruadi; Embodiment Of The Andung Batak Toba Tradition Into A Three-Part Fantasia Music Composition)
Authors: Pane Wulan Puriani Batman Sitorus , Herdianto Ferry , Anggraini Nora
Published: December 2024

Andung Ni Si Boruadi  dalam bahasa Batak Toba berarti ratapan seorang gadis adalah sebuah karya komposisi musik  yang berangkat dari reinterpretasi terhadap budaya andung yang ada di masayarakat Batak Toba. Andung adalah nyanyian ratapan seseorang yang murni atau refleks saat sedang berduka. Dalam karya ini, aspek suasana, karakteristik dan teknik andung akan  menjadi ide garapan yang digarap ke dalam sebuah komposisi musik fantasia tiga bagian. Karya  komposisi ini digarap dengan menggunakan metode penciptaan yaitu:  Interpretasi, orkestrasi dan improvisasi. Bagian penting dalam proses penggarapan karya ini terdiri dari ide tema garapan, tangga nada, sistem atonal, teknik pengembangan, motif sulim, motif hasapi dan motif taganing. Komposisi musik Fantasia Andung Ni Si Boruadi digarap ke dalam formasi full orkestra yang dikolaborasikan dengan penggunaan alat musik tradisonal Batak Toba yaitu sulim  ( Seruling) dan pada bagian tertentu, penggarap memunculkan si pangandung (orang yang meratap) untuk menguatkan tema dari Andung  tersebut. Hasil karya komposisi musik ini yaitu musik programa ideational  dengan bentuk fantasia tiga bagian yang diberi judul Fantasia Andung Ni Si Boruadi.ABSTRACTAndung Ni Si Boruadi in the Toba Batak language means a girl's lament is a musical composition that departs from a reinterpretation of the Andung culture in the Toba Batak community. Andung is a pure or reflexive lamentation of someone when they are grieving. In this work, aspects of the atmosphere, characteristics and techniques of andung will be the ideas worked on into a three-part fantasia musical composition. This compositional work was worked on using creative methods, namely: interpretation, orchestration and improvisation. An important part of the process of creating this work consists of the theme ideas, scales, atonal systems, development techniques, sulim motifs, hasapi motifs and taganing motifs. The musical composition Fantasia Andung Ni Si Boruadi was worked on into a full orchestral formation which was collaborated with the use of traditional Toba Batak musical instruments, namely the sulim (flute) and in certain parts, the composers brought out si pandung (people who wail) to strengthen the theme of Andungthe. The result of this musical composition is ideational programmatic music in the form of a three-part fantasia entitled Fantasia Andung Ni Si Boruadi.
Imitation Of The Song Bareh Solok Through Vocals Of Graphic Improved Students At SLB Waraqil Jannah, West Sumatra.
Authors: Saputra Rizky , Emridawati Emridawati , Irwan Irwan , Martarosa Martarosa
Published: December 2024

SLB Waraqil Jannah is a special school in West Sumatra, which has mentally retarded students who have problems with limited speech, slow thinking and communication. This research aims to reveal this problem through the application of imitation learning of the Bareh Solok song and find out the results of this application. This research is of the Qualitative type with a Descriptive Analysis approach, using Constructivism theory, Imitation theory and Learning theory. Data collection techniques: literature study and field study, and data analysis using Milles and Huberman theory: data reduction, data presentation, and drawing conclusions. The results of this research show that Waraqil Jannah SLB students can perform the song Bareh Solok through the vocals of mentally retarded students as a creativity enhancement which was carried out at Mifan Padangpanjang City
Evaluating Axial Strength of Cold-formed C-Section Steel Columns Filled with Green High-performance Concrete
Authors: Jasim Al Mashhadani D. A. , Wong Leong Sing , Al-Zand Ahmed W. , Kong Sih Ying
Published: December 2024

Concrete-filled steel tube (CFST) columns that experience outward local buckling under high axial stress remain a significant concern, particularly when thin steel sections are used, as opposed to semi-compact and compact sections. This study investigated the performance of column systems by comparing single- and double-C-section configurations with both hollow and concrete-filled designs. Two types of infill materials were investigated: normal concrete and recycled material concrete, which included 10% waste glass powder as a cement replacement, 8% black high-density polyethylene beads as a sand substitute, and 10% pumice stone as coarse aggregate. To enhance the strength of the proposed CFS column, steel strips and screws were used to connect the flanges of the C-sections. Nine columns were tested experimentally under static axial load. Additionally, finite element analysis software was used to model and evaluate the effects of parameters beyond those investigated in the tests. The results indicated that the load capacity of the double face-to-face section was approximately 3% higher than that of the double back-to-back section. The addition of steel strips, used to connect the lips of the C-section flanges, enhanced the axial strength of the column by approximately 2% compared with the unstrengthened corresponding specimen and delayed buckling in the most vulnerable areas. Furthermore, the recycled infill concrete material had a minimal impact on the axial performance of the analyzed CFS columns compared to the control concrete, with a difference of less than 2.2%. The findings confirm that recycled waste material concrete can achieve performance comparable to that of the conventional concrete. Doi: 10.28991/CEJ-SP2024-010-014 Full Text: PDF
Safety evaluation of the food enzyme containing endo‐polygalacturonase and β‐glucosidase from the non‐genetically modified Aspergillus tubingensis strain ARO
Authors:   EFSA Panel on Food Enzymes (FEZ Panel), Zorn Holger , Barat Baviera José Manuel , Bolognesi Claudia , Catania Francesco , Gadermaier Gabriele , Greiner Ralf , Mayo Baltasar , Mortensen Alicja , Roos Yrjö Henrik , Solano Marize L. M. , Sramkova Monika , Van Loveren Henk , Vernis Laurence , Tokić Valentina , Criado Ana , Marini Eleonora , Cabo Laura Sanmartin , Liu Yi
Published: December 2024

Abstract
The food enzyme containing endo‐polygalacturonase and β‐glucosidase (EC 3.2.1.15 and EC 3.2.1.21) is produced with the non‐genetically modified Aspergillus tubingensis strain ARO by DSM Food Specialties B.V. The food enzyme was free from viable cells of the production organism. It is intended to be used in five food manufacturing processes. Dietary exposure was estimated to be up to 0.609 mg total organic solids (TOS)/kg body weight per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 2217 mg TOS/kg bw per day, the highest dose tested, resulting in a margin of exposure of at least 3640. A search for the homology of the amino acid sequence of the food enzymes to known allergens was made and four matches with food allergens and 22 matches with respiratory allergens were found. Known sources of food allergens were used in the food enzyme manufacturing process. The Panel considered that the risk of allergic reactions upon dietary exposure cannot be excluded. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
THE IMPORTANCE OF EVALUATING A WORK OF ART IN THE ARTIST’S WORK
Authors: Efimenko V.
Published: December 2024

The analysis of the results of artistic creation, as well as the attitudes of authors, audiences, and experts towards them, is of particular relevance in contemporary culture, characterized by its inherent variability and fluidity of values. The process by which a work acquires social value attracts sustained research interest. This article aims to examine aspects such as: the alignment of the author’s creative aspirations with societal demands; the possibility and right of an individual artist to declare their work as a public aesthetic value; the commensurability of authorial and public evaluation of an artwork; and the artist’s interest in receiving competent opinions. The article clarifies the paths by which artists gain recognition, as well as the factors influencing an artist’s career, and the changes in the author’s emotional state depending on the correspondence of their creative aspirations to the needs of the sociocultural environment. It also concretizes the boundaries of the artist’s self-expression that are accessible to the viewer’s understanding. A methodological feature of this research is its reliance on the memoirs of artists and biographical sketches of art figures. Keywords: artwork, artist, evaluation of visual art, art critic, viewer
Medical education and the epidemics: How educational technology responded
Authors: Alsaif Bander S. , Ibrahem Usama M. , Alblaihed Munthir A. , Ahmed Sameh S. I. , El Tobely Tarek E. , Mayor Losito B. , Alshrif Haisam A. , Diab Hanan M.
Published: December 2024

The global disruption created by the Coronavirus Disease 2019 (COVID-19) pandemic in medical education and healthcare institutions is unparalleled. Consequently, it is essential to evaluate the usability of forms of educational technology and to identify their viability and suitability for medical education. The objective of the investigation was to present an assessment of the state of medical education during the COVID-19 epidemic and to identify the obstacles faced by educators while introducing online learning systems for medical students. Two cross-sectional surveys were conducted with 200 medical students and 75 staff members from Saudi Arabia's University of Health. A descriptive method was used to focus on the mechanisms of analysis, foresight, and comprehension of reality. The most significant findings were the obstacles posed by instructors' most urgent requirements for educational technology training and its applications in order to activate distance education in medical education. In addition to a detailed description of the academic and technological concerns and obstacles encountered by students and faculty of health colleges during the pandemic, this report includes a discussion of the pandemic itself. Several prospective recommendations for the use of online and blended learning in health colleges post-pandemic were also made. Additionally, the requirement to activate learning via virtual professional learning groups.
Decoding global reproductive health discourse on Reddit: themes, regions, and misinformation challenges
Authors: Selvi Arul A , Arulchelvan S.
Published: December 2024

This study explores dominant themes in global reproductive health discussions on Reddit over a 12-month period (January 2021 to December 2021). We collected and analyzed 50,000 posts and 100,000 comments from key subreddits, including "r/ReproductiveHealth" and "r/Parenting," using Python libraries like PRAW and BeautifulSoup for efficient data collection and preprocessing. Employing tools such as Latent Dirichlet Allocation (LDA) for topic modeling and VADER for sentiment analysis, we identified five major themes: Family Planning and Contraception, Pregnancy and Childbirth, Sexual Education and Awareness, Misinformation and Myths, and Support and Emotional Well-being. Geospatial analysis revealed regional variations, with North America and Europe emphasizing family planning, while Asia and Africa took the lead in discussions on pregnancy and childbirth. Our findings shed light on a global dispersion of misinformation discussions, emphasizing the challenges posed by misinformation in online reproductive health conversations. This research provides a nuanced understanding of prevalent themes and community engagement, contributing valuable insights to the dynamics of reproductive health discussions on Reddit.
Effectiveness of simulation-based paediatric cardiopulmonary resuscitation training program among nursing students in Saudi Arabia
Authors: Dharmarajlu Santhi M. , Dailah Hamad G. , Anuratha MD
Published: December 2024

The main objective of this study was to adopt a simulation-based advanced cardiac life support training program to assess nursing students' level of knowledge and practice regarding paediatric advanced cardiac life support and to identify the major knowledge and practice gaps. The methods used in this study were pre-experimental, one group pre and post-test investigation. This study was conducted between September 2022 and November 2022, at the University College of Farasan in the Kingdom of Saudi Arabia. Quantitative data were obtained using the “Cardio Pulmonary Resuscitation Knowledge Questionnaire”, “Students’ Satisfaction and Self-Confidence Scale,” and the “CPR Skill Checklist,” which were applied to 75 participants in focus groups. Before the simulation-based CPR training, the students' mean pre-test Paediatric CPR knowledge score was 6.5±2.3 out of 42.0. After the simulation, the mean post-test CPR knowledge score (38.1±2.9) considerably improved (p 0.05). The mean post-test CPR skills score (44.7±1.2) was also considerably higher than the mean pre-test CPR skills score (11.4±2.8) at (p 0.05). Additionally, after the simulation training, students' happiness and confidence levels (61.9±2.2) greatly increased. Themes from the qualitative data showed that the simulation was viewed as an engaging and effective teaching tool by the students. Two themes emerged from the study: "Worries before simulation" and "Satisfaction after simulation". Simulation-based paediatric cardio Pulmonary resuscitation training program has raised nursing students’ level of expertise in knowledge, performance, and self-efficacy. Additionally, strong satisfaction and self-confidence levels were discovered following the simulation training.
Indigenous sexual and reproductive health practices by girls in Makhado Municipality: A qualitative study
Authors: Bopape Ndivhuwo H. , Randa Moreoagae B. , Mudau Selina T.
Published: December 2024

Cultural practices are passed from one generation to the other. There has been limited evidence of willingness to use indigenous practices to enhance sexual and reproductive health among the youth in resource-constrained settings. This study aimed to explore the possibilities of reintroducing indigenous practices to enhance sexual and reproductive health education among girls. The study adopted a qualitative approach through participatory action research. Non-probability, purposive sampling was used to recruit girls aged 9-18. Data were generated through focus group discussions and key informant interviews. The study findings revealed that indigenous practices were beneficial in delaying sexual debut and nurturing self and peer respect. Additionally, girls appreciated indigenous knowledge and preferred introducing innovative approaches to promoting it. Youth involvement in indigenous knowledge and practices on sexual and reproductive health practices is paramount. The need to introduce critical dialogue to introduce innovative approaches to promoting indigenous practices to enhance sexual and reproductive health is imperative.
THE CULTURAL IMPLICATIONS OF THE SEMANTICS OF APPARELS IN LITERATURE: A CRITICAL STUDY
Authors: Jose Jessykutty
Published: December 2024

Apparel can be considered an object of sociological and historical research since it is drawn out of a mass of a society independent of the individual whereas dressing implies the personal mode with which the wearer adopts the dress that is proposed to them by their social group. We are likely to come across a kind of coincidence between dress and dressing. There is always a kind of ambiguity as to how an item of clothing evolves and eventually changes and this confusion makes the plotting of a history of clothing rather difficult. The dress which cannot be reduced to its protective or ornamental function is a privileged semiotic field. The signifying function of dress makes it a social object. The elements of fashion are also seen as applied to the world of fiction as well as its movie adaptations. The peculiarities of a character’s inner self and the strong ties it has with the development of the plot make the attire of a character vital in terms of the unsaid facts about the characters as well as their lives. Linking a character and the plot with the way he/she carries himself/herself makes the act of reading more interesting. In this paper, a critical study is made on the processes and images that apparels provide for the characters in a literary work, based on the linguistic model proposed by Roland Barthes.
A STUDY ON CONSUMER PERCEPTION TOWARDS ELECTRIC VEHICLES IN BENGALURU CITY
Authors: L Smitha
Published: December 2024

The study's goal was to investigate how consumers see electric cars (EVs) and assess the variables that affect their choice to buy one. The survey also sought to determine how Bengaluru city's consumers felt about electric cars. Using a descriptive study design, a quantitative research approach was used. A questionnaire that was given to customers of E-vehicle users was used to gather data. Approximately 145 respondents made up the sample, which was chosen using convenience sampling methods. According to the study's findings, consumer perceptions of factors like reducing air pollution and greenhouse gas emissions, gender, refuelling habits, the impact of government incentives and financial gains, curiosity, exposure to media sources and references, heterophily and serving as a source of information, affordability—both in terms of price and vehicle range—and design and style are all positively correlated with consumers' propensity to purchase electric vehicles. Technological elements that positively correlate with consumers' favourable perceptions of purchasing electric vehicles include disruptive innovation, advancements in battery technology, price premium reductions, superior e-vehicle service, low noise levels, operating costs, and energy independence through a decrease in oil imports.
A SMART VOTING SYSTEM COMBINING FINGERPRINT AND FACIAL RECOGNITION FOR ENHANCED SECURITY
Authors: Yadu Amitesh , Chandrakar Om Prakash
Published: December 2024

Bogus (fake) voting is still a major drawback in elections. In Aadhaar card, the government has all our data base including finger print and retina. Biometric finger print devices and web cameras are used in electronic voting machines for voter verification. We have designed a smart voting machine where the user does not need to carry his ID which contains his necessary details. The person present at the polling station need only place his/her finger in the finger print scanner and capture the facial recognition on the web camera at the polling station counter, thus allowing to obtain on-spot fingerprint and facial recognition from the voter who Works. an identity. This data is sent to the control unit for verification. The controller receives data from the reader and compares this data with already existing data stored during voter registration. If the data matches the pre-stored information of the registered fingerprint and face, the person is allowed to cast his/her vote. If not, a warning message is displayed on the LCD and a warning is given through voice, thus stopping the person from casting his/her vote. The mechanism of casting votes is done manually using a keyboard. The LCD is used to display relevant messages, warnings and upcoming results.
SURROUNDED BY WATER, QUENCHING FOR THIRST: DRINKING WATER ISSUE IN NORTH KUTTANADU, A SPECIAL REFERENCE WITH KAVALAM
Authors: Nair Akshara A. , Satheesh Aswathy , R. Harikrishnan , B. Madhusudhan
Published: December 2024

Kuttanad, often known as the "rice bowl of Kerala," is a 900-square-foot delta region on the west coast of Alappuzha, with coordinates of 9.3428 degrees N and 76.4240 degrees E. Add diversity to the environment by incorporating Greenland, patches, fisheries, flora, wildlife, rivers, ponds, and backwaters. The only area in all of India below sea level that reclaims and converts polders, wetland areas, and backwater areas for paddy farming is Kuttanad. Every topographical configuration in Kuttanad has advantages and disadvantages. Specifically, the study examines the effects of textile washing and untreated sewage outflow on the water availability and quality in the region caused by human activities. The study analyses the quality of the water, conducts community interviews, and conducts field surveys to evaluate the extent of pollution and its impact on the local populace. The findings demonstrate the pressing need for all-encompassing measures to address the root causes of the water contamination in Kavalam Kuttanad. It is recommended that the initial steps in lessening the situation involve the implementation of awareness programs that promote acceptable water use habits in conjunction with an effective wastewater treatment infrastructure. Additionally, community involvement and stakeholder engagement are essential to ensure the sustainability of long-term solutions.
Analysis of Connections between Process Standards and Content Standards in Mathematics Curriculum
Authors:   The Korea Society Of Educational Studies In Mathematics, Chang Hyewon , Lee Ye-Jin
Published: December 2024

The purpose of this study is to clarify the meaning of process standards in the evolving of the curriculum and to analyze the connection between mathematical processes and contents in foreign mathematics curricula in order to derive implications for the Korean context. In the current Korean curriculum, the meaning of process standards is applied inconsistently, and clear criteria for the behavioral verbs used to describe them are lacking. To address this issue, six types of connections between process and content were identified from both form and content perspectives, and relevant foreign curricula were examined. The analysis revealed that the curricula of New York State and Ireland explicitly connect process standards to content standard by directly aligning them with specific learning elements. Based on these findings, this study suggests ways to improve the connection between process and content standards in the Korean curriculum, either by explicitly specifying process standards that correspond to content standards or by adopting a process-oriented approach to curriculum design.
Comments on the Definition of Real Numbers via Infinite Decimal Expansion
Authors:   The Korea Society Of Educational Studies In Mathematics, Lee Dong Hwan , Cho Jinseok
Published: December 2024

Lee(2014; 2015) claimed that, in the program of the pre-service school teacher training, real numbers should be defined using the infinite decimal expansion so as to resolve the double discontinuity problem between school and college mathematics. Li(2011) wrote a mathematical paper on the construction of the real numbers via the infinite decimal expansion and supported the argument. On the other hand, Park(2016) analyzed Li's paper and showed that this paper contains the error of circular logic using ‘limit to a real number’. This study shows that Park(2016) misunderstood the introduction of Li's paper and revealed that appropriate axiom must be assumed to avoid the error of circular logic in real number construction. Through this, we resolved the confusion in the studies of Lee(2014; 2015) and Park(2016) and discussed the implications for pre-service school teacher education proposed in each study could be compatible with each other.
EDUKASI MITIGASI BENCANA GEMPA BUMI DI SMAN 2 SELONG, LOMBOK TIMUR
Authors: Jayatri Adella Ulyandana , Inayah Rahmatun , Aminy Ika Umratul Asnii , Kurniawidi Dian Wijaya , Saputra Kormil , Ardianto Teguh , Fortuna Gianta Arya Dwi
Published: December 2024

Pulau Lombok merupakan wilayah dengan risiko tinggi gempa bumi karena terletak di zona subduksi lempeng tektonik. Rentetan gempa pada tahun 2018 menyebabkan dampak signifikan, termasuk kerusakan infrastruktur, korban jiwa, dan trauma psikologis masyarakat. Minimnya pemahaman masyarakat, khususnya pelajar, terkait mitigasi bencana menjadi salah satu penyebab tingginya kerugian. Penelitian ini bertujuan untuk meningkatkan pemahaman dan kesiapsiagaan siswa melalui program edukasi mitigasi bencana gempa di SMAN 2 Selong, Lombok Timur. Program ini mencakup pengenalan gempa bumi, tanda-tanda dan peringatan dini, prinsip konstruksi bangunan tahan gempa, langkah kesiapsiagaan, serta pemanfaatan media sosial dalam menghadapi bencana. Metode edukasi melibatkan penyampaian visual, diskusi, dan simulasi evakuasi. Hasil kegiatan menunjukkan peningkatan pemahaman siswa terhadap gempa bumi dan mitigasinya, serta antusiasme dalam mengikuti simulasi. Edukasi ini diharapkan dapat membekali siswa dengan pengetahuan dan keterampilan praktis dalam menghadapi bencana, sekaligus meminimalisir risiko kerugian di masa depan. Temuan ini menekankan pentingnya integrasi mitigasi bencana dalam kurikulum pendidikan di wilayah rawan gempa
Exploring Promising Therapies for Advanced Non-Small-Cell Lung Cancer
Authors: Mello Ramon Andrade de
Published: December 2024

Lung cancer persists as a leading cause of cancer-related mortality across the globe, with a discernible rise in incidence among women in both developed
and developing regions. Lung cancer is broadly classified into two major subtypes:
small-cell lung cancer and non-small-cell lung cancer (NSCLC). NSCLC accounts for approximately 85% of all lung cancers, subdivided into three
principal histological types: adenocarcinoma (AC), squamous cell carcinoma
(SCC), and large-cell carcinoma. NSCLC is a highly aggressive type of lung cancer that is usually diagnosed at an advanced stage. In this advanced stage, tumors cannot be surgically removed and systemic treatment (chemotherapy,
immunotherapy, or targeted therapy) is needed1.
Second-line therapy options for patients with advanced NSCLC who had
progressed after first-line chemotherapy have substantially changed since the approval of the anti-PD-1 antibody nivolumab and the anaplastic lymphoma
kinase (ALK) inhibitor crizotinib. Prognosis for patients with advanced
NSCLC is poor, emphasizing the unmet need for novel approaches
to treat this disease. Genetic alterations in NSCLC have been extensively investigated
in recent years. With the rapid advancement of next-generation
sequencing technologies, there is an increase in the number of cancer-associated
genomic alterations being discovered. The first success was the identification of EGFR mutations in 2004.
Currently, major subgroups of NSCLC patients can