bluuebunny/crossref_metadata_2025 huggingface dataset:
DeepSeek Vs. ChatGPT: A Comparative Evaluation of AI Tools in Composition, Business Writing, and Communication Tasks
Authors: AlAfnan Mohammad Awad
Published: February 2025

This study presents a comparative evaluation of DeepSeek and ChatGPT, two AI-powered text generation models, in composition, business writing, and communication tasks. The article assesses AI-generated content based on clarity, coherence, adaptability, persuasiveness, and grammatical accuracy, with evaluations conducted by three expert instructors. The findings indicate that ChatGPT outperforms DeepSeek, particularly in linguistic variation, audience awareness, and dynamic content generation. ChatGPT demonstrates superior tone modulation, rhetorical adaptability, and engagement, making it more effective for persuasive messaging, business communication, and content creation. In contrast, DeepSeek excels in grammatical precision, structural organization, and factual consistency, making it a more reliable tool for formal reports and standardized business writing. The study also examines the strategies employed by both AI models, highlighting ChatGPT’s strength in customizing responses to different audiences and business contexts, while DeepSeek often follows a one-size-fits-all approach, resulting in rigid and impersonal writing. Although ChatGPT proves more adaptable, its responses occasionally require refinement for conciseness and formality, whereas DeepSeek would benefit from improvements in creativity, emotional intelligence, and flexibility. The findings underscore the broader implications of AI-driven writing tools in business, education, and professional communication. Organizations can maximize AI’s potential by leveraging ChatGPT for dynamic and persuasive communication while utilizing DeepSeek for structured, technical, and compliance-based writing. Future advancements should focus on enhancing AI adaptability, domain-specific customization, and ethical considerations in AI-generated content, ensuring effective integration into modern professional environments.
As a Consequences of the Law of Unilaterally Closing Road Access for Public Road Interests (Case Study of Register Number 92 / Pdt.G / 2021 / PN. Sim)
Authors: Alberto Paskah Tarigan  , Hisar Siregar  , Roida Nababan
Published: February 2025

This research examines the legal consequences of unilaterally closing public road access based on case study Number 92/Pdt.G/2021/PN. Sim. This closure gave rise to legal and social disputes in society. With a normative juridical approach, this research analyzes legal bases such as the UUPA, Civil Code, and Road Law. The research results show that the act of closing road access without a valid legal basis violates the principle of the social function of land rights (Article 6 UUPA) and can be categorized as an unlawful act (Article 1365 of the Civil Code). The main obstacles in resolving disputes are the defendant's non-compliance with legal decisions and weak enforcement of regulations. Therefore, it is necessary to strengthen regulations regarding road access, increase the government's role in mediating land disputes, as well as legal education for the community to prevent similar conflicts in the future.
Artificial intelligence as applied to classifying epoxy composites for aircraft
Authors: Yasniy Oleh , Maruschak Pavlo , Mykytyshyn Andrii , Didych Iryna , Tymoshchuk Dmytro
Published: February 2025

The problem of classification of epoxy composites used for the manufacture of aircraft structures is solved by machine learning methods: neural network, reinforced trees and random forests. Classification metrics were obtained for each method used. Parameters such as precision, recall, F1 score and support were determined. The neural network classifier demonstrated the highest results. Boosted trees and random forests showed slightly lower results than the neural network method. At the same time, the classification metrics were high enough in each case. Therefore, machine learning methods effectively classify epoxy composites. The results obtained are in good agreement with the experimental ones. The prediction accuracy score obtained using each method was greater than 0.88.
The value of creative activities in the recreational field: the grounded theory perspective
Authors: Lisauskienė Dovilė , Leščinskij Robert
Published: February 2025

The current article employs a constructivist grounded theory approach to analyze the relationship between recreation and creativity. Researchers explore how engaging in imaginative recreational activities foster and sustain social connections, emphasizing the importance of social settings and interactions. In the context of recreation, creativity is highlighted as a crucial process enriched with educational and developmental elements, characterized by originality and usefulness. The value of creative activities is particularly stressed, noting their ability to transform emotions, replace negative feelings with positive ones, and enhance self-confidence among young people. This self-confidence serves as a medium for socialization and self-development. Additionally, the role of communication is emphasized, as creative activities provide youth with opportunities to communicate and build social ties.
A Long-term Study of Mrk 50: Appearance and Disappearance of Soft Excess
Authors: Layek Narendranath , Nandi Prantik , Naik Sachindra , Jana Arghajit
Published: February 2025

We present an extensive temporal and spectral study of the Seyfert 1 AGN Mrk 50 using 15 yr (2007–2022) of multiwavelength observations from XMM-Newton, Swift, and NuSTAR for the first time. From the timing analysis, we found that the source exhibited variability of ∼20% during the 2007 observation, which reduced to below 10% in the subsequent observations and became nonvariable in the observations from 2010 onward. From the spectral study, we found that the spectra are nearly featureless. Nondetection of absorption in the low-energy domain during the 15 yr of observation infers the absence of obscuration around the central engine, rendering the nucleus a “bare” type. A prominent soft X-ray excess below 2 keV was detected in the source spectrum during the observations between 2007 and 2010, which vanished during the later observations. To describe the nature of the soft excess, we use two physical models, such as warm Comptonization and blurred reflection from the ionized accretion disk. Both of the physical models explain the nature and origin of the soft excess in this source. Our analysis found that Mrk 50 accretes at a sub-Eddington accretion rate (λ
Edd = 0.13–0.02) during all of the observations used in this work.
Effect of pyrrole and xanthine derivatives on the contractility of A. basilaris
Authors: Kadinov Boris , Mateeva Alexandrina , Georgieva Maya , Mitkov Yavor , Zlatkov Alexander , Kondeva-Burdina Magdalena
Published: February 2025

Oxidative stress plays a key role in the progression of neurodegenerative processes. Based on the etymology of these diseases, another common factor is impaired blood supply, which leads to cerebral ischemia. In the current study, the effects of pyrrole and xanthine derivatives on the contractility of the rat cerebellum A. basilaris were evaluated. To aim this purpose, the A. basilaris was isolated from 10 white rats, and the contractility was elucidated through wire myography. The obtained results demonstrated a good vasodilating dose-dependent effect of compound ethyl 5-(4-bromophenyl)-1-(3-hydrazinyl-3-oxopropyl)-2-methyl-1H-pyrrole-3-carboxylate (12), lowering arterial contractility, while the caffeine derivatives N-(1-methyl-2-phenylethyl)-2-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl-sulfanyl)-acetamide (JTA3) and N-(tetrahydrofuran-2-ylmethyl)-2-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetamide (JTA5) increases vascular tone, with JTA5 having a transient effect.
MARA Vegetation Database: Monitoring Alien species along mountain Roads in the central Apennines
Authors: Santoianni Lucia Antonietta , Bartolucci Fabrizio , Carboni Marta , Conti Fabio , La Bella Greta , Varricchione Marco , Stanisci Angela
Published: February 2025

The MARA (Monitoring Alien species along mountain Roads in the central Apennines) database was developed to monitor the distribution of vascular plant species along mountain roads in the Central Apennines, Italy, focusing on alien (i.e. neophytes) and thermophilous plant species. Data were gathered in 2022 from 118 plots spanning an elevation range from 420 to 2125 meters a.s.l. along 3 main road corridors on three massifs (Gran Sasso, Maiella and Terminillo), following the MIREN road survey protocol. The database comprises 810 taxa (species and subspecies), of which 16 are identified as alien taxa. Major plant families in frequency are Asteraceae, Poaceae, and Fabaceae. MARA captures detailed information on species cover, taxonomy, and ecological traits, such as life forms and Ecological Indicator Values for Europe (EIVE) related to temperature. Notably, 53% of the alien species recorded were thermophilous, thriving in warmer environments, and predominantly concentrated below 1200 meters, though a few species extend to higher elevations. This suggests that rising temperatures due to climate change may facilitate the upward movement of these species, potentially disrupting native vegetation. For such reasons, the MARA database is a valuable resource for long-term ecological monitoring, providing valuable data for both national and international research networks.
Use of Continuous Glucose Monitoring in Skilled Nursing Facilities: Strategies for Managing Implementation
Authors: Keers Lucy G. , Brodeur Michael R. , Tran Lara
Published: February 2025

Purpose

Continuous glucose monitoring (CGM) devices are increasingly used by older adults. Although these devices offer several advantages over traditional techniques, such as fingerstick capillary blood glucose, the current article discusses the impact and benefits of CGMs in the context of older adults in skilled nursing facilities (SNFs) and explores ways to improve and manage their use through the collaboration of an interprofessional team.

Method

Current evidence and guidance on implementing CGM devices in SNFs is reviewed.

Results

Current strategies for the successful and safe use of CGM devices in SNFs include staff and patient education, close monitoring, operational workflow, and interprofessional collaboration.

Conclusion

To manage patients with diabetes in SNFs, an interactive, multidisciplinary, and multifaceted approach is needed. Larger studies on the management of CGM devices in SNFs are required. [
Journal of Gerontological Nursing, 51
(3), 7–12.]
Le «sonnet de comparaison» dans “L’Hécatombe à Diane”: un espace propice au surgissement du «je»
Authors: Caro Sarah
Published: February 2025

By drawing up a typology of the ‘sonnets of comparison’ in L’Hécatombe à Diane and then comparing them with those of some contemporary poets, this article examines Agrippa d’Aubigné’s own strategy for introducing the first person singular at the beginning of the tercets, and thus misappropriating the Petrarchan topos of comparison for enunciative purposes. In doing so, we will observe that he takes a stand against the poets of the 1570s generation, so that by dramatising the irruption of the ‘I’ in his sonnets, d’Aubigné is also asserting a personal and original voice in the history of love poetry.
L’«exercitatio» strophique dans les “Odes” d’Agrippa d’Aubigné
Authors: Chabroux-Richin Julie
Published: February 2025

The stanza is often overlooked in studies of poetics, and this tendency is even more pronounced during the Renaissance, where it is practically absent from rhetorical treatises. Despite this theoretical neglect, the usage, dating back to Marot, has clearly demonstrated the extent to which poets exploit this scale of verse combination to carry out their lyrical experiments. Agrippa d’Aubigné is not exempt from this poetic exercitatio, as evidenced by the considerable variety of strophes at work in the Odes of Le Printemps. Building upon this reconstructed corpus, this article aims to illustrate how the stanza of the ode constitutes a privileged place for the poet in terms of rhythmic, syntactic, and sonic composition.
«Et le vent en emporte autant»: violence et légèreté dans “Le Printemps”
Authors: Payen De La Garanderie Adèle
Published: February 2025

After a discussion on the value of inconstancy, both erotic and existential, in Le Printemps, we demonstrate that instability even impacts the structures of language. We suggest to make it a characteristic feature of the «folâtre» style that the poet tries in this collection. By reviewing three major metapoetic pieces, the «Préface», the Ode XXVI and the «Poème de l’Inconstance», we reflect upon d’Aubigné’s conception of language in its relationship to the rhetorical simplicity requirement, to metaphorical thinking, to the mechanisms of linguistic fixedness and to iconicity. A word alchemist, an arsonist of images and a soldier of eloquence from the heart, d’Aubigné violently criticizes the deceptions of speech. Perhaps what sets him apart from Ronsard and his contemporaries is his hyper-sensitivity to the intensity of human experience, which always makes speaking null and void.
«Dans le corps de la mort, j’ai enfermé ma vie»: le motif du mort-vivant dans “Le Printemps” d’Agrippa d’Aubigné
Authors: Closson Marianne
Published: February 2025

Readers will readily recall from Printemps, and especially from the Hécatombe à Diane and the Stances, the horrible image of the bloody chest of the lover whose heart has been torn out and offered as a holocaust to the cruel Diana. This metaphorical motif, inherited from Petrarchanism, is not, however, unrelated to the author’s convictions and life experiences. His interest in the occult sciences and, more generally, his acceptance, albeit suspicious and worried, of the irruption of the supernatural into real life, can be seen in his Lettres sur les divers points de science and in Sa vie à ses enfants. Agrippa d’Aubigné, through the obsessive figure of the living dead, with whom he identified, questioned the porosity of the boundaries between the worlds of the living and the dead.
Female voices and bodies in “Le Printemps”: an invitation, via annotated English translations, to bring Agrippa d’Aubigné’s love poetry into comparative literature courses
Authors: Worth-Stylianou Valérie
Published: February 2025

Le Printemps deserves to feature in comparative literature courses on love poetry. To encourage my colleagues to take up this challenge, I provide an annotated English translation, for university students, of four poems from the collection. The two sonnets and two longer poems all share a focus either on the female voice, or on a female body without a voice. I ask whether, when d’Aubigné lends his voice to a female character – whether his wife or an Ovidian heroine –, he is really giving them agency, or rather strengthening his own control through their voices. In addition, these poems showcase the wide range of styles with which d’Aubigné experiments in Le Printemps, and I argue that to appreciate them it is also crucial to recognise the intertextual dialogues he sets up with classical and contemporary poets.
L’età delle macchine: automi e simulacri anatomici in Leopardi
Authors: Leydi Enrica
Published: February 2025

L’articolo esplora la tensione estetico-mimetico-epistemologica tra immagine poetica e modello scientifico nell’opera di Giacomo Leopardi, soffermandosi sui casi della meccanica e dell’anatomia. Attraverso l’analisi di brani dallo Zibaldone, dalla Proposta di premi fatta dall’Accademia dei Sillografi e dal Dialogo di Federico Ruysch e delle sue mummie, il saggio sostiene che per Leopardi il paradigma meccanico-anatomico rappresentato da automi e modelli anatomici promuove una conoscenza limitata e razionale del mondo, escludendone la dimensione poetica e relazionale, che è invece possibile cogliere attraverso il “colpo d’occhio”. Automi e macchine anatomiche, quindi, non sono perfette rappresentazioni della natura, ma possono tuttavia diventare potenti immagini poetiche e strumenti di satira contro la pretesa esaustività e assolutezza della conoscenza scientifica.
Oralidade, gêneros orais e formação de professores:
Authors: Bueno Luzia , Rodrigues de Sousa Fabiana , Baptista Wesley
Published: February 2025

Este artigo tem como objetivo refletir sobre o trabalho com a oralidade e os gêneros orais na  formação de professores/as. Para isso, apoiando-nos em quadros teóricos-metodológicos que ressaltam o papel da linguagem, da pronúncia coletiva do mundo e da educação na formação humana, visando à construção de uma sociedade com consciência crítica e transformadora, analisamos grades curriculares de cursos de graduação para tratarmos da formação inicial e iniciativas de formação continuada. Os resultados indicam que  os documentos oficiais ainda não destacam a importância da oralidade e dos gêneros orais na formação de professores/as, todavia há iniciativas que colocam os/as docentes em diálogo apreendendo-os como protagonistas de fato e de direito das decisões sobre a organização de seu trabalho. Tais iniciativas têm condições de superar as limitações impostas pelas prescrições iniciais ao proporem novos caminhos da sala de aula para as ruas da cidade.
retextualização de contos do livro Olhos d’água para gêneros orais: uma proposta para a formação de professores
Authors: Pimentel Ajala Juliana , Bragiatto Gabriel Aparecido , Amador Mascia Márcia Aparecida
Published: February 2025

O presente artigo tem por objetivo contribuir para a reflexão de uma proposta de formação de professores para o trabalho com gêneros orais, e discutir a importância do trabalho com a oralidade na formação docente, articulando os saberes a ensinar aos saberes para ensinar. Para isso, partimos dos estudos dos processos de retextualização da fala para a escrita (Marcuschi, 2010), articulando-os ao quadro que mobilizamos para o ensino de gêneros orais: o Interacionismo Sociodiscursivo (Bronckart, 1999, 2019), além das discussões sobre a Didática do Oral, Modelo Didático e Sequência Didática (Dolz, Noverraz e Schneuwly, 2004). Metodologicamente assumimos uma perspectiva qualitativo-interpretativa a partir da qual analisamos o desfecho de três trabalhos de estudantes da pedagogia, que concerne na retextualização de um texto escrito, no caso, um conto do livro “Olhos d’água”, de Conceição Evaristo, para um texto de gênero oral. Os resultados indicam que o desenvolvimento da atividade contribuiu para que os estudantes pensassem a respeito de gêneros orais de forma analítica e reflexiva, adquirindo um conhecimento sobre a oralidade que poderá contribuir para o seu próprio desenvolvimento das capacidades de linguagem na modalidade oral e para apropriação de um conhecimento que deverá ser objeto de ensino desses futuros professores.
Entrevista de emprego na Educação de Pessoas Jovens e Adultas: contribuições de Marcuschi para refletir sobre o gênero oral na prática docente
Authors: Katrine da Silva Bilro Fabrini , Barbosa Maria Lúcia Ferreira de Figueirêdo , Costa-Maciel Débora Amorim Gomes da
Published: February 2025

Quais contribuições de Marcuschi podem ser observadas quando docentes tratam com o gênero de oral? Essa inquietação move este artigo, que se comprometeu em analisar como duas professoras em atuação na Educação de Pessoas Jovens e Adultas (EJA) planejam/vivenciam o ensino do gênero entrevista de emprego. Com vistas a atingir o objetivo, realizamos uma conversar/partilha em um ambiente virtual e, a partir da gravação, destacamos extratos de fala que nos ajudassem a entender, de modo qualitativo, as contribuições teóricas defendidas pelo autor em tela. Os resultados evidenciaram a presença de Marcuschi, sobretudo, na compreensão que as professoras relevaram em relação aos elementos constitutivos do gênero e sua função social. Além disso, há uma atenção no trato com o gênero para as particularidades do público da EJA, para as dimensões extralinguísticas e paralinguísticas que compõem o encadeamento de estratégias de reflexão sobre esferas mais formais de uso da linguagem oral.
Oralidade nas práticas translíngues: a construção do relato pessoal
Authors: Juliotti Julia , Figueira Guimarães Thayse , Buin Barbosa Edilaine
Published: February 2025

Este artigo apresenta os resultados de uma pesquisa-ação realizada em uma escola pública brasileira situada em uma região de fronteira entre o Brasil e o Paraguai, com o objetivo de demonstrar como práticas translíngues e transculturais podem promover a diversidade linguística e cultural no ensino de língua portuguesa. Articulando reflexões sobre práticas pedagógicas voltadas para o ensino de gêneros orais e a promoção da diversidade nas práticas educativas regulares, o estudo investigou turmas de 7º ano do Ensino Fundamental II, adaptando o gênero textual "relato pessoal" para uma sequência didática. A metodologia envolveu a análise de momentos significativos em que os estudantes utilizaram a oralidade e a escrita como práticas complementares, contribuindo para o desenvolvimento de suas competências linguísticas e socioculturais. O referencial teórico inclui as concepções de letramento e ensino de gêneros orais (Marcuschi, 2001a,b), além das noções de translinguagem (García & Wei, 2014) e transculturalidade (Welsch, 1999), que fornecem uma base para argumentar que a integração dessas práticas nas aulas favorece o letramento pleno e a inclusão de diferentes línguas e culturas presentes na comunidade escolar. Os resultados demonstram que práticas translingues e transculturais facilitam a construção de identidades linguísticas e culturais diversas, além de enriquecer o processo de ensino-aprendizagem ao valorizar a pluralidade linguística e suas modalidades. Assim, o estudo reforça a importância da oralidade, até mesmo quando o produto final de uma sequência de atividades é um gênero escrito.
The Metaverse in Education
Authors: Monteiro Ana Catarina , Rodrigues Maria Antónia
Published: February 2025

The metaverse, which is still in its infancy, has great potential to transform education, enabling the creation of immersive, three-dimensional virtual environments where students can interact dynamically, carry out simulations, and make teaching more diverse and inclusive. This chapter, through a case study, sought to understand how and why educational institutions are exploiting the metaverse. The results of this research provided a better understanding of the process of creating a metaverse platform for teaching, as well as important variables to consider, highlighting the objectives with the presence in the metaverse, the overall strategy of the educational institution, and the technological infrastructure. The conclusions offer valuable insights for other institutions interested in adopting metaverse in education, helping to guide strategic decisions, and exploring the potential of this emerging technology.
Integration of Industry 4.0 With Personalized Medicine
Authors: Waaje Abdul , Karim Rejaul , Roshid Md. Mustaqim , Yeamin Bony , Meem Tamanna Nusrat
Published: February 2025

The convergence of personalized medicine and Industry 4.0 technologies is revolutionizing healthcare by enabling precise, efficient, and patient-centered interventions. This chapter investigates the integration of these two transformative domains, emphasizing their combined potential to enhance patient care, therapeutic outcomes, and healthcare delivery systems. Personalized medicine principles, including genetic profiling, biomarker identification, targeted therapies, predictive modeling, therapeutic monitoring, patient stratification, and data integration, are explored in depth, demonstrating their alignment with Industry 4.0 innovations. Technologies such as artificial intelligence, big data analytics, and the Internet of Things (IoT) are reshaping diagnostics, treatment customization, and real-time monitoring. Despite promising advancements, challenges persist, including data security, ethical concerns, and integration complexities.
Artificial Intelligence in Diagnostics and Disease Screening Transforming Healthier Homes
Authors: Singh Bhupinder
Published: February 2025

AI is disrupting the disease screening diagnostics and turning our homes into a healthier ecosystem. Wearable, connected smart home devices and health monitoring applications powered by AI assist in the early diagnosis and ongoing tracking of long-term illnesses such as heart disease, diabetes, asthma and hyper-responsible. AI can predict the risk of health, detect anomalies and activate interventions before situations occur by means of real-time data from sensors and devices. AI is also aiding in diagnostics by means of broad scale testing for infectious diseases with the muscle of remote symptom tracking, which helps efficient plan and prepare disease prevention & containment measures. This consumer adoption of home-based AI integration helps individuals to manage their own health more effectively, promotes wellness and can alleviate the current strain on our traditional healthcare infrastructure.
Mental Health and AI
Authors: Bhakuni Pawan , Punia Aanchal , Sharma Nitin
Published: February 2025

Mental health is a crucial aspect of overall well-being, significantly impacting emotional, psychological, and social functioning. The integration of artificial intelligence (AI), particularly natural language processing (NLP), into mental healthcare holds transformative potential. By leveraging advanced algorithms, AI can analyze diverse data sources, including electronic health records and behavioral patterns, to enhance diagnosis, treatment planning, and intervention delivery. NLP-driven tools such as virtual therapists provide continuous support and personalized care, increasing the accessibility and scalability of mental health services. This ultimately leads to improved clinical outcomes and heightened patient engagement. Through this introductory perspective, the chapter highlights both the opportunities posed by AI and NLP in mental health, setting the stage for a deeper exploration of their roles in shaping the future of mental health care.
Smart Parking Systems With Machine Learning
Authors: Jain Ashima , Singh Bhupinder , Raghav Anjali
Published: February 2025

Traffic congestion has turned into a vital urban challenge throughout the world because it generates notable economic strain and damage to the environment. The rising automobile usage coupled with expanding metropolitan populations has made traffic congestion more severe and regular. A review of the analysis investigates the monetary as well as ecological consequences stemming from urban traffic congestion while presenting possible solutions to reduce its harmful effects. The chapter discusses established traffic management solutions together with contemporary smart parking systems along with accident detection technologies. The research shows that road transportation must become actively involved in congestion management through systematic methods to recognize congestion causes while implementing directed solutions as well as monitoring systems for tracking traffic flow.
Furosemide’s Preventative Role in Contrast-Induced Nephropathy among ST-Segment Elevation Myocardial Infarction Patients undergoing Percutaneous Coronary Intervention
Authors: Ariafar Mostafa , Ghorbani Parvin , Seyedian Seyed Masoud , Ahamdi Farzaneh , Sabetnia Leila , Farhadi Elham
Published: February 2025

Background:

ST-elevation myocardial infarction (STEMI) is regarded as a risk factor for contrast-induced nephropathy (CIN). Numerous studies have explored preventive measures for CIN such as the use of diuretics. However, the specific impact of diuretics in averting nephropathy remains uncertain. We investigated whether post-treatment with furosemide decreases CIN risk.

Materials and Methods:

We designed a clinical trial and included 234 patients with STEMI undergoing primary percutaneous coronary intervention (PCI). Patients were divided into two groups: Group I (furosemide 0.5 mg/kg) and Group II (control). Serum creatinine and blood urea nitrogen (BUN) were measured pre- and post-surgery. CIN was described as more than either 25% or 0.5 mg/dL induction in serum creatinine from the baseline in 24 h and 72 h post-PCI.

Results:

CIN occurred in 33 patients (14.1%) in 24 h and 35 patients (14.9%) in 72 h. CIN incidence was not significantly different between both groups. However, BUN was significantly higher in the furosemide group (P < 0.05). Most patients in the furosemide group were men and smokers compared to the control group.

Conclusion:

A combination of low-dose furosemide plus standard hydration was not correlated with lower CIN incidence in STEMI patients who are candidates for primary PCI compared to standard hydration only. Further studies with a larger sample size in the future are needed to better understand the effects of this combination.
The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking
Authors: Farajnabi Roghayeh , Hojjati Bonab Zahra , Shagayegh Neda
Published: February 2025

Background:

Helicobacter pylori is a Gram negative bacterium in the human stomach. Considering the side effects of the drug regimen and the prevalence of antibiotic resistance, in this project, the antimicrobial effect of aloe vera extracts on Helicobacter pylori was tested.

Materials and Methods:

Evaluation of the antimicrobial effect of aloe vera extract on Helicobacter pylori was done using diffusion methods in agar, and the diameter of the nongrowth halo was measured. The molecular interaction between the active ingredients of aloe vera and urease enzyme was investigated with Mulgroo Virtual Docker (MVD) software.

Results:

The diameter of the halo of no growth at a concentration of 1000 mg/ml in aloe vera was 19 mm, and the maximum diameter of no growth was observed in the ethanolic extract.

Conclusion:

According to our results, the ethanolic extract of aloe vera can be suggested as a good option as an antimicrobial supplement for Helicobacter pylori.
Role of IGFBP-3 in Human Diseases Relying on Different Cell Signaling Pathways
Authors: Naseri Nima , Mofid Mohammad Reza
Published: February 2025

Insulin growth factor protein 3 (IGFBP-3) is a member of the binding protein family which is known as the main carrier of insulin-like growth factors in human serum. Through the existence of multiple IGFBP-3 binding partners such as insulin growth factors (IGFs), transmembrane receptor 219 (TMEM219) protein, retinoid X receptors (RXRs), and other proteins, in IGF-dependent and IGF-independent cell signaling pathways, IGFBP-3 exerts the various key roles associated with physiological processes such as cell growth prevention and differentiation, apoptosis induction and have several metabolic activities such as regulating blood glucose, lipid metabolism, regulating bone, and chondrocyte growth as well. Moreover, IGFBP-3 plays an important role in the pathophysiology of a variety of human diseases including ischemia, Alzheimer’s disease, diabetes mellitus, asthma, and cancer. Therefore, in this current study, we intend to describe the IGFBP-3 role depending on its effect on the pathophysiology of human illnesses.
Predictive value of microRNA-122 in obesity and metabolic syndrome
Authors: Abdelhafez Aisha H. , Abdel Fattah Wafaa M. , Seliem Nora , Mohamed Eman F.
Published: February 2025

Background and aim

Metabolic syndrome (MetS) is a collection of metabolic dysregulations such as hypertension, insulin resistance, atherogenic dyslipidemia, and central obesity. MicroRNA-122 (miR-122) was the first of the many circulating miRNAs linked to metabolic diseases and obesity. MiR-122 is a liver-enriched miRNA that influences lipid and cholesterol metabolism. This study aims to evaluate the miR-122 function in the obesity’s pathogenesis and to assess the possible association of miRNA-122 with MetS in obese patients.

Patients and methods

The study included 50 Egyptian individuals (20 healthy persons as control, 15 obese patients without MetS, and 15 obese patients with MetS). The levels of miR-122 were validated using quantitative reverse transcription real-time polymerase chain reaction tests.

Results

Serum miR-122 demonstrated a highly significant increase in obese patients collectively compared with the control (P<0.001). Moreover, miR-122 demonstrated upregulation expression in obese cases having MetS compared with controls and the obese without MetS. There were statistically significant strong positive correlations between miR-122 expression and BMI, waist circumference, blood pressure, markers of dysglycemia, and dyslipidemia. Also, there were negative correlations with high-density lipoprotein (all having P=<0.001).

Conclusion

MiR-122 could be a valuable biomarker of obesity’s pathogenesis and MetS in obese patients.
Quality of life of mothers of children with autistic disorder
Authors: Hamed Amira M.M. , Aladawy Mohammed A. , Gaad Eman F. , Khodery Aml R.A.
Published: February 2025

Background and aim

Quality of life (QoL) assessment for families of autistic children has become a crucial research topic. Purpose of this study was to evaluate the QoL of mothers of children diagnosed with autistic disorder.

Patients and methods

This prospective study included 50 children diagnosed with autistic disorder according to autism spectrum disorder (ASD) diagnostic criteria by DSM-5, aged from 2 to 16 years, in addition to their mothers.

Results

This study found that 80% of the mothers in the study reported low QoL and that mothers of children with severe ASD rated their QoL worse than mothers of children with mild and moderate ASD. The degree of QoL affection was more in the subgroup with attention deficit hyperactivity disorder comorbidity. Also, the QoL of mothers is affected by the level of intelligence quotient impairment in their children, with the lowest mean QoL scores in mothers of severely mentally defective children. By comparing between QoL scores before and after child behavioural therapy, the results showed that the post-test QoL scores had increased significantly.

Conclusion

QoL was rated low in mothers whose children had autistic disorder. Mothers’ QoL was shown to be substantially related to the degree of ASD symptoms among their children. However, giving behavioral treatment sessions to those children was linked to a significant increase in the mothers’ QoL.
Value of middle cerebral artery and umbilical artery Doppler indices in preeclamptic patients and their correlation with outcomes
Authors: Mustafa Faisal A. , Mohamed Duaa H. , Ahmed Yasser A.A.
Published: February 2025

Background and aim

Preeclampsia is an important factor contributing to prenatal prematurity, intrauterine growth retardation, and the death of mothers. It is clinically evident after 20 weeks of gestation and impacts ∼5–10% of pregnancies. This study aimed to compare middle cerebral artery (MCA) and umbilical artery (UA) Doppler indices in preeclampsia patients versus normotensive pregnant ladies and to correlate the effect of MCA and UA Doppler indices with outcomes intrauterine growth retardation, perinatal death, and prematurity.

Patients and methods

This prospective case–control study was conducted on 100 cases divided into two groups: 50 women who have the diagnosis of preeclampsia according to recent guidelines of the International Society for the Investigation of Hypertension in Pregnancy and 50 normotensive pregnant ladies as a control group in Al-Azhar University Hospital in a period starting from July 2021 to July 2023.

Results

The best diagnostic accuracy for the prediction of adverse outcomes of preeclampsia was noticed with UA resistive index [90% with an area under the curve (AUC) was 0.90] followed by UA pulsatility (78% with AUC was 0.80) and MCA resistive index (76% with AUC was 0.75). Also, the UA systolic diastolic ratio had 70% overall accuracy for the prediction of preeclampsia with the AUC was 0.74.

Conclusion

UA and MCA Doppler indices were worse in preeclamptic versus nonpreeclamptic ladies. Worse Doppler indices were correlated with a greater incidence of adverse neonatal findings and were predictive of preeclampsia.
Comparison between hysterosalpingography and three-dimensional sonohysterography in infertile women
Authors: Muhammad Muhammad A.S. , Fathy Medhat K. , Salem Omar M.M.
Published: February 2025

Background and aim

Infertility is characterized as the failure to achieve conception naturally following 1 year of consistent sexual activity that is unprotected. This study aimed to compare three-dimensional sonohysterography (3D-SIS) versus radiograph hysterosalpingography (HSG) in the evaluation of infertile ladies.

Patients and methods

This cross-section study was performed on 50 infertile women who underwent 3D-SIS and standard HSG between 7th and 12th day of their menstrual cycles from patients visiting the gynecological clinic at Al-Azhar University outpatient facility in Assiut.

Results

Regarding tubal patency and tubal blocking in HSG and 3D-SIS, there were highly significant differences (P<0.001). Regarding intrauterine lesions in HSG and 3D-SIS, there were highly significant differences which represent that 3D-SIS was more accurate and specific than HSG (P<0.001). Visual analog scale score pain value, HSG represents 48% mild pain, 34% moderate, and 18% severe pain, while; 3D-SIS represents 70% mild pain, 28% moderate, and 2% severe pain. Regarding pain value in HSG and 3D-SIS, there were highly significant differences, which represents that pain was tolerable in 3D-SIS other than HSG (P<0.001).

Conclusion

3D-SIS provides the best outcomes alternative to HSG in infertile women regarding tubal patency, intrauterine lesion, and pain. The elevated sensitivity of HSG has rendered it an effective screening instrument for intrauterine anomalies.
Incidence and risk factors of pulmonary embolism in cancer patients
Authors: Mohammed Omar G.M. , Abd-Allah Hamdy M. , Gabr Adel G.M. , Abdalla Hytham , Mohammed Hossam A.E.-M.
Published: February 2025

Background and aim

Pulmonary embolism (PE) is a critical complication significantly more prevalent in cancer patients due to factors such as hypercoagulability, immobility, and chemotherapy. The incidence and risk factors vary with cancer type, treatment, and patient demographics, necessitating a detailed investigation to enhance management and outcomes.

This study aimed to evaluate the incidence and identify risk factors of PE in cancer patients, focusing on demographics, clinical characteristics, and outcomes to inform prevention strategies.

Patients and methods

Conducted at the South Egypt Cancer Institute, this study combined retrospective and prospective analyses of cancer patients admitted over a year. It involved history taking, clinical and laboratory evaluations, and radiological investigations to identify PE cases and associated risk factors.

Results

Among 294 patients, 91 were diagnosed with PE. Significant risk factors included a history of surgery (62.6% in the PE group vs. 34.9% in non-PE) and previous deep vein thrombosis (82.4% vs. 2.9%). The PE group showed a higher mean international normalized ratio and D-dimer levels. Breast, thyroid, and lung cancers were the most associated with PE. Anticoagulant therapy predominantly involved low-molecular-weight heparin.

Conclusion

Cancer patients, particularly those with a history of surgery or deep vein thrombosis, exhibit a higher risk of PE, with specific cancer types showing greater association. These findings underscore the necessity for vigilant PE risk assessment and management in cancer patients, advocating for further research to validate these observations.
Sclerotherapy injection in management of aneurysmal bone cyst
Authors: Abdallah Ahmed Ehab A. , Khashaba Ahmed S.I. , Elwany Hasan Abdallah M.
Published: February 2025

Background and aim

Aneurysmal bone cyst (ABC) is a benign bone lesion of childhood and adolescence. It can be locally aggressive, with risk of fracture. Management is controversial. The study aimed to assess radiologically the healing of ABC together with assessment of Patient’s functional and physiological activities in response to Polidocanol with adjuvant bone marrow injection.

Patients and methods

This prospective case–series study was conducted on 20 patients with ABCs of long bones (femur, tibia, and humerus) that were managed by sclerotherapy (polidocanol) injection at Al-Azhar University Hospitals, Department of Orthopedics and Trauma Surgery, between 2022 and 2023.

Results

The mean initial visual analogue scale (VAS) for pain was 6.2±1.3. Before the fourth injection, the mean VAS declined to 1.9±1.4. The pain level continued to decline from 1 to 12 months after the fourth injection. At 12 months following the fourth injection, the mean VAS for pain was 0.3±0.48. Regarding postoperative complications, one patient developed nausea and vomiting, and two patients reported ecchymosis at the injection site.

Conclusion

We assessed the radiological healing of ABC in response to Polidocanol injection, together with an assessment of functional and physiological activities. Percutaneous intervention is the treatment of choice now in the management of ABC as it is effective, less invasive, and more cosmetically with no donor site morbidity as in conventional open intervention.
Risks of Malignancy among 11,204 Patients with Endometrial Polyp: A Systematic Review and Meta-analysis
Authors: Al-Rayes Sarah , Mohamed Mariam , Suarthana Eva , Kigloo Hormoz Nassiri , Raina Jason , Tulandi Togas
Published: February 2025

Objectives:

To evaluate factors associated with malignancy in patients with endometrial polyps.

Materials and Methods:

We conducted electronic database research on PubMed, MEDLINE, EMBASE, COCHRANE, and Google Scholar from inception for all studies on endometrial polyp. After removing duplicates, and title and abstract screening, we had a total of 121 articles and 151 others from screening the reference list. Inclusion criteria included peri and postmenopausal women > 45 years diagnosed histopathologically with endometrial polyp(s). We excluded women with a history of endometrial cancer or hysterectomy.

Results:

Twenty studies were analyzed. Of 11204 patients with endometrial polyp, 287 had malignant polyps (2.75%), 182 (1.8%) had concomitant endometrial hyperplasia with atypia, and 520 (5.2%) had hyperplasia without atypia within the polyp. Menopausal women had a higher risk of pre-malignancy/malignancy than non-menopausal women (OR 5.63 (95CI 3.87, 8.20, I
2 = 0%, P < 0.001). Endometrial thickness on ultrasound in pre-malignancy/malignancy cases was significantly thicker than in the benign polyp (mean difference 4.2 mm, 95% CI 0.8 to 7.6 mm, I
2 = 18%, P = 0.02). Women who used tamoxifen or hormone replacement therapy (HRT) had a lower likelihood of endometrial pre-malignancy/malignancy, while women with abnormal uterine bleeding (AUB) had a higher probability of pre-malignancy/malignancy. The odd ratio of having pre-malignancy/malignancy among those who used tamoxifen was 0.50 (95% CI 0.26-0.94: I
2 12%, p = 0.03).

Conclusion:

In women with endometrial polyp, menopausal age and thickened endometrium might increase the probability while tamoxifen or HRT use might lower the likelihood of endometrial pre-malignancy/malignancy; and the presence of AUB might signal endometrial pre-malignancy/malignancy.
Glazy Erythema on Glans Penis in a 3-year-old Child: An Unusual Diagnosis of Zoon’s Balanitis Aided by Dermoscopy
Authors: Katakam Bhumesh K. , Udhayini Kalimi V. , Chintagunta Sudharani , James Hitha A.
Published: February 2025

Zoon’s balanitis is a benign inflammatory non-venereal genital dermatosis occurring in males. Cayenne pepper spots, a characteristic feature of Zoon’s balanitis, present as erythematous macule with red, pinpoint-like dots. Uncircumcised males between the ages of 40 and 80 are usually affected. Though usually asymptomatic, some individuals may experience discomfort, burning sensations, or pruritus. The majority of the reported cases are older uncircumcised men and the lesion involves glans penis and/or prepuce. We hereby report an uncommon presentation of Zoon’s balanitis in a 3-year-old preschool child.
Prevalence of Generalized and Abdominal Overweight-Obesity among Adolescents from Punjab State: Their Possible Risk Drivers
Authors: Choudhary Shivangi , Bhandari Anmol , Tung Suninder , Kaur Gurcharan
Published: February 2025

Background:

Childhood overweight/obesity is currently most pressing public health concerns in the 21st century. This study aimed to estimate the prevalence of generalized and abdominal overweight/obesity and their correlations in adolescents from State of Punjab, India. The study further assessed various lifestyle habits as possible risk drivers of overweight/obesity such as dietary habits, physical activity, sleep time, screen time, etc.

Methodology:

This cross-sectional study was performed on 1408 adolescents aged 10–16 years from seven schools in Punjab, India. Prevalence of overweight/obesity was measured using four criteria Body Mass Index, Waist Circumference, Waist Hip ratio, and Waist/Height ratio were taken as indicators of generalized and abdominal obesity. The cut-off of >23rd and >27th adult equivalent BMI for overweight and obesity was used. 545 adolescents (healthy weight and overweight/obese) were then randomly selected for their lifestyle assessment.

Results:

The overall prevalence of overweight and obesity based on BMI was 18.6% and 12.4% respectively. Abdominal obesity was 11% by WC, 32.4% by WHR, and 24.6% by WHtR. All three waist indices showed significant correlation with BMI (P < 0.001). The prevalence of overweight/obesity among boys was significantly higher than girls when measured by BMI Vs WC, WHR, and WHtR. Significant association was also observed between measures of obesity and age, with higher prevalence in adolescents of 10-13 than 14-16 years. Overweight/obesity was not significantly associated with their possible lifestyle risk drivers.

Conclusion:

Overweight/obesity in adolescents showed significant association with gender and age, and the prevalence of overweight/obesity was found to be significantly higher as compared to the previous reports from India.
Single-Nucleotide Polymorphism TAQI, APAI, BSMI, and its Possible Association with the Prevalence of Dental Caries
Authors: Nireeksha  , Suchetha N. Kumari
Published: February 2025

Aim:

Dental caries is a multifactorial disease influenced by dietary habits, genetic factors, and peptides modulating the tooth structure. This study evaluates whether salivary vitamin D levels and single-nucleotide polymorphisms in the vitamin D receptor (VDR) gene impact dental caries susceptibility.

Materials and Methods:

This cross-sectional observational study involved 377 participants aged 18–40, divided into caries-active and caries-free groups. Salivary DNA was analyzed for VDR polymorphisms (TaqI, ApaI, and BsmI) using polymerase chain reaction-restriction fragment length polymorphism, and biochemical levels of vitamin D and LL-37 were measured. Potential confounders such as nutritional status and oral hygiene habits were controlled. Statistical analysis included ANOVA and logistic regression with confidence intervals.

Results:

Salivary vitamin D levels were significantly lower in the caries-active group (20.85 ± 11.20 pg/mL) compared to the caries-free group (28.56 ± 10.42 pg/mL, P < 0.001). No significant differences were observed in LL-37 levels between groups. VDR TaqI and ApaI polymorphisms showed strong associations with dental caries (P < 0.001). Logistic regression revealed the protective role of specific genotypes, such as CC in TaqI and AA in ApaI.

Clinical Implications:

The study findings suggest that salivary vitamin D and VDR polymorphisms could serve as noninvasive biomarkers for predicting dental caries susceptibility and guiding personalized preventive strategies.