bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of catastrophizing, anxiety, and depression on in-hospital opioid consumption, pain, and quality of recovery after adult spine surgery
Authors: Dunn Lauren K. , Durieux Marcel E. , Fernández Lucas G. , Tsang Siny , Smith-Straesser Emily E. , Jhaveri Hasan F. , Spanos Shauna P. , Thames Matthew R. , Spencer Christopher D. , Lloyd Aaron , Stuart Russell , Ye Fan , Bray Jacob P. , Nemergut Edward C. , Naik Bhiken I.
Published: November 2017

OBJECTIVE

Perception of perioperative pain is influenced by various psychological factors. The aim of this study was to determine the impact of catastrophizing, anxiety, and depression on in-hospital opioid consumption, pain scores, and quality of recovery in adults who underwent spine surgery.

METHODS

Patients undergoing spine surgery were enrolled in this study, and the preoperatively completed questionnaires included the verbal rating scale (VRS), Pain Catastrophizing Scale (PCS), Hospital Anxiety and Depression Scale (HADS), and Oswestry Disability Index (ODI). Quality of recovery was assessed using the 40-item Quality of Recovery questionnaire (QoR40). Opioid consumption and pain scores according to the VRS were recorded daily until discharge.

RESULTS

One hundred thirty-nine patients were recruited for the study, and 101 completed the QoR40 assessment postoperatively. Patients with higher catastrophizing scores were more likely to have higher maximum pain scores postoperatively (estimate: 0.03, SE: 0.01, p = 0.02), without increased opioid use (estimate: 0.44, SE: 0.27, p = 0.11). Preoperative anxiety (estimate: 1.18, SE: 0.65, p = 0.07) and depression scores (estimate: 1.06, SE: 0.71, p = 0.14) did not correlate with increased postoperative opioid use; however, patients with higher preoperative depression scores had lower quality of recovery after surgery (estimate: −1.9, SE: 0.56, p < 0.001).

CONCLUSIONS

Catastrophizing, anxiety, and depression play important roles in modulating postoperative pain. Preoperative evaluation of these factors, utilizing a validated tool, helps to identify patients at risk. This might allow for earlier psychological intervention that could reduce pain severity and improve the quality of recovery.
Neurosurgical management in children with bleeding diathesis: auditing neurological outcome
Authors: Zakaria Zaitun , Kaliaperumal Chandrasekaran , Crimmins Darach , Caird John
Published: November 2017

OBJECTIVE

The aim of this study was to assess the outcome of neurosurgical treatment in children with bleeding diathesis and also to evaluate the current management plan applied in the authors’ service.

METHODS

The authors retrospectively analyzed all cases in which neurosurgical procedures were performed in pediatric patients presenting with intracranial hematoma due to an underlying bleeding tendency over a 5-year period at their institution. They evaluated the patients’ neurological symptoms from the initial referral, hematological abnormalities, surgical treatment, neurological outcome, and scores on the Pediatric Glasgow Outcome Scale–Extended (GOS-E Peds) obtained 1 year after the last operation.

RESULTS

Five patients with a bleeding diathesis who underwent surgery for intracranial hematoma were identified; the diagnosis was hemophilia A in 3 cases, idiopathic thrombocytopenic purpura in 1 case, and severe aplastic anemia in 1 case. Intracerebral hematoma (ICH) (n = 4) and acute subdural hematoma (n = 1) were confirmed on radiological investigations. In 2 of the 4 patients with ICH, the diagnosis of bleeding diathesis was made for the first time on presentation. Four patients (all male) were younger than 2 years; the patient with severe aplastic anemia and spontaneous ICH was 15 years old and female. The duration of symptoms varied from 24 hours to 5 days. Neurological examination at 1 year’s follow-up showed complete recovery (GOS-E Peds score of 1) in 3 cases and mild weakness (GOS-E Peds score of 2) in 2 cases.

CONCLUSIONS

Neurosurgical management of patients with bleeding diathesis should be carried out in a tertiary-care setting with multidisciplinary team management, including members with expertise in neuroimaging and hematology, in addition to neurosurgery. Early diagnosis and prompt treatment of a bleeding diathesis is crucial for full neurological recovery.
Morphometric and volumetric comparison of 102 children with symptomatic and asymptomatic Chiari malformation Type I
Authors: Khalsa Siri Sahib S. , Geh Ndi , Martin Bryn A. , Allen Philip A. , Strahle Jennifer , Loth Francis , Habtzghi Desale , Urbizu Serrano Aintzane , McQuaide Daniel , Garton Hugh J. L. , Muraszko Karin M. , Maher Cormac O.
Published: November 2017

OBJECTIVE

Chiari malformation Type I (CM-I) is typically defined on imaging by a cerebellar tonsil position ≥ 5 mm below the foramen magnum. Low cerebellar tonsil position is a frequent incidental finding on brain or cervical spine imaging, even in asymptomatic individuals. Nonspecific symptoms (e.g., headache and neck pain) are common in those with low tonsil position as well as in those with normal tonsil position, leading to uncertainty regarding appropriate management for many patients with low tonsil position and nonspecific symptoms. Because cerebellar tonsil position is not strictly correlated with the presence of typical CM-I symptoms, the authors sought to determine if other 2D morphometric or 3D volumetric measurements on MRI could distinguish between patients with asymptomatic and symptomatic CM-I.

METHODS

The authors retrospectively analyzed records of 102 pediatric patients whose records were in the University of Michigan clinical CM-I database. All patients in this database had cerebellar tonsil position ≥ 5 mm below the foramen magnum. Fifty-one symptomatic and 51 asymptomatic patients were matched for age at diagnosis, sex, tonsil position, and tonsil morphology. National Institutes of Health ImageJ software was used to obtain six 2D anatomical MRI measurements, and a semiautomated segmentation tool was used to obtain four 3D volumetric measurements of the posterior fossa and CSF subvolumes on MRI.

RESULTS

No significant differences were observed between patients with symptomatic and asymptomatic CM-I related to tentorium length (50.3 vs 51.0 mm; p = 0.537), supraoccipital length (39.4 vs 42.6 mm; p = 0.055), clivus-tentorium distance (52.0 vs 52.1 mm; p = 0.964), clivus-torcula distance (81.5 vs 83.3 mm; p = 0.257), total posterior fossa volume (PFV; 183.4 vs 190.6 ml; p = 0.250), caudal PFV (152.5 vs 159.8 ml; p = 0.256), fourth ventricle volume to caudal PFV ratio (0.0140 vs 0.0136; p = 0.649), or CSF volume to caudal PFV ratio (0.071 vs 0.061; p = 0.138).

CONCLUSIONS

No clinically useful 2D or 3D measurements were identified that could reliably distinguish pediatric patients with symptoms attributable to CM-I from those with asymptomatic CM-I.
[bmim]PF6/KOH: A Recyclable Catalytic System for an Azide–Arylacetaldehyde [3 + 2] Cycloaddition
Authors: Jiang Yuqin , Wu Kai , Tan Xuxia , Zhang Dandan , Dong Wenpei , Li Wei , Xu Guiqing , Zhang Weiwei
Published: November 2017

A fast and green protocol for the synthesis of 1,4-disubstituted 1,2,3-triazoles from azides and arylacetaldehydes at room temperature was developed using [bmim]PF6/KOH as the reaction medium. It was found that the in situ-generated carbene from [bmim]PF6/KOH acted as the catalyst. In the absence of a transition-metal catalyst and organic solvent, this azide–arylacetaldehyde [3 + 2] cycloaddition proceeds efficiently, with high levels of regioselectivity, broad range of substrates, excellent yields and simple operation under mild conditions.
Characteristic Analysis and Fault-Tolerant Control of Circulating Current for Modular Multilevel Converters under Sub-Module Faults
Authors: Wu Wen , Wu Xuezhi , Yin Jingyuan , Jing Long , Wang Shuai , Li Jinke
Published: November 2017

A modular multilevel converter (MMC) is considered to be a promising topology for medium- or high-power applications. However, a significantly increased amount of sub-modules (SMs) in each arm also increase the risk of failures. Focusing on the fault-tolerant operation issue for the MMC under SM faults, the operation characteristics of MMC with different numbers of faulty SMs in the arms are analyzed and summarized in this paper. Based on the characteristics, a novel circulating current-suppressing (CCS) fault-tolerant control strategy comprised of a basic control unit (BCU) and virtual resistance compensation control unit (VRCCU) in two parts is proposed, which has three main features: (i) it can suppress the multi-different frequency components of the circulating current under different SM fault types simultaneously; (ii) it can help fast limiting of the transient fault current caused at the faulty SM bypassed moment; and (iii) it does not need extra communication systems to acquire the information of the number of faulty SMs. Moreover, by analyzing the stability performance of the proposed controller using the Root-Locus criterion, the election principle of the value of virtual resistance is revealed. Finally, the efficiency of the control strategy is confirmed with the simulation and experiment studies under different fault conditions.
Research on the Temperature Field of High-Voltage High Power Line Start Permanent Magnet Synchronous Machines with Different Rotor Cage Structure
Authors: Cao Zhaobin , Li Weili , Li Jinyang , Zhang Xiaochen , Li Dong , Zhang Meiwei
Published: November 2017

For line start permanent magnet synchronous machines (LSPMSMs), the eddy current loss in the rotor, which has of significant effects on rotor working temperature, may cause thermal demagnetization to permanent magnet. Therefore, this paper addresses an investigation on the temperature distribution in LSPMSM based on a 6 kV, 315 kW prototype with solid starting cage bar. Firstly, the loss distributions, obtained from a 2-D transient electromagnetic field calculation, are determined as the distributed heat source in thermal analyses. Then, the fluid-thermal coupled analyses are performed, by which the temperature distributions in the machine are determined. Meanwhile, the calculated motor performance is verified via comparison with the measured results. The calculation results show that the temperatures in the rotor core and permanent magnets are relatively high. To find the solution for reducing the rotor working temperature, a rotor air slot structure was proposed in this analysis. The theoretical calculation indicates that the rotor working temperature reduction is obvious with the rotor air slot in the machine. Therefore, the operating situation of solid rotor LSPMSM could be improved effectively with the proposed rotor thermal solution, which also benefits the machine reliability and safety.
Research on Stress Sensitivity of Fractured Carbonate Reservoirs Based on CT Technology
Authors: Yang Yongfei , Liu Zhihui , Sun Zhixue , An Senyou , Zhang Wenjie , Liu Pengfei , Yao Jun , Ma Jingsheng
Published: November 2017

Fracture aperture change under stress has long been considered as one of primary causes of stress sensitivity of fractured gas reservoirs. However, little is known about the evolution of the morphology of fracture apertures on flow property in loading and unloading cycles. This paper reports a stress sensitivity experiment on carbonate core plugs in which Computed Tomography (CT) technology is applied to visualize and quantitatively evaluate morphological changes to the fracture aperture with respect to confining pressure. Fracture models were obtained at selected confining pressures on which pore-scale flow simulations were performed to estimate the equivalent absolute permeability. The results showed that with the increase of confining pressure from 0 to 0.6 MPa, the fracture aperture and equivalent permeability decreased at a greater gradient than their counterparts after 0.6 MPa. This meant that the rock sample is more stress-sensitive at low effective stress than at high effective stress. On the loading path, an exponential fitting was found to fit well between the effective confining pressure and the calculated permeability. On the unloading path, the relationship is found partially reversible, which can evidently be attributed to plastic deformation of the fracture as observed in CT images.
Monetary Valuation of Natural Forest Habitats in Protected Areas
Authors: Pechanec Vilem , Machar Ivo , Sterbova Lenka , Prokopova Marcela , Kilianova Helena , Chobot Karel , Cudlin Pavel
Published: November 2017

The progressive development of economic valuations of biodiversity in recent decade enables the application of the concept of payments for ecosystem services (PES) in order to conservation of forest biodiversity in protected areas. In this article, the PES concept principles are applied for the monetary valuation of natural forest habitats, which were mapped in the Czech Republic in order to create the Natura 2000 European network. The method is based on expert evaluation of every type of mapped habitat by a point value (ranging from 1 to 6 points) for specific ecological evaluating criteria. The monetary value of every point of specific natural forest habitats was defined from the economic analysis of financial expenses of realised ecological restoration projects in the Czech Republic. This method is therefore based on a rather exceptional application of the PES concept, which is still rare in literature because it is based on actual invested financial means, not only on the potential willingness to spend these financial means. The presented results of the monetary valuation of the natural forest habitats in the Czech Republic indicate that the method used for the monetization of forest biodiversity in protected areas can represent a promising decision support tool in countries where habitat mapping results are available.
Next Generation Sequencing of Chromosome-Specific Libraries Sheds Light on Genome Evolution in Paleotetraploid Sterlet (Acipenser ruthenus)
Authors: Andreyushkova Daria , Makunin Alexey , Beklemisheva Violetta , Romanenko Svetlana , Druzhkova Anna , Biltueva Larisa , Serdyukova Natalya , Graphodatsky Alexander , Trifonov Vladimir
Published: November 2017

Several whole genome duplication (WGD) events followed by rediploidization took place in the evolutionary history of vertebrates. Acipenserids represent a convenient model group for investigation of the consequences of WGD as their representatives underwent additional WGD events in different lineages resulting in ploidy level variation between species, and these processes are still ongoing. Earlier, we obtained a set of sterlet (Acipenser ruthenus) chromosome-specific libraries by microdissection and revealed that they painted two or four pairs of whole sterlet chromosomes, as well as additional chromosomal regions, depending on rediploidization status and chromosomal rearrangements after genome duplication. In this study, we employed next generation sequencing to estimate the content of libraries derived from different paralogous chromosomes of sterlet. For this purpose, we aligned the obtained reads to the spotted gar (Lepisosteus oculatus) reference genome to reveal syntenic regions between these two species having diverged 360 Mya. We also showed that the approach is effective for synteny prediction at various evolutionary distances and allows one to clearly distinguish paralogous chromosomes in polyploid genomes. We postulated that after the acipenserid-specific WGD sterlet karyotype underwent multiple interchromosomal rearrangements, but different chromosomes were involved in this process unequally.
Brain Atrophy Estimated from Structural Magnetic Resonance Imaging as a Marker of Large-Scale Network-Based Neurodegeneration in Aging and Stroke
Authors: Veldsman Michele
Published: November 2017

Brain atrophy is a normal part of healthy aging, and stroke appears to have neurodegenerative effects, accelerating this atrophy to pathological levels. The distributed pattern of atrophy in healthy aging suggests that large-scale brain networks may be involved. At the same time, the network wide effects of stroke are beginning to be appreciated. There is now widespread use of network methods to understand the brain in terms of coordinated brain activity or white matter connectivity. Examining brain morphology on a network level presents a powerful method of understanding brain structure and has been successfully applied to charting the course of brain development. This review will introduce recent advances in structural magnetic resonance imaging (MRI) acquisition and analyses that have allowed for reliable and reproducible estimates of atrophy in large-scale brain networks in aging and after stroke. These methods are currently underutilized despite their ease of acquisition and potential to clarify the progression of brain atrophy as a normal part of healthy aging and in the context of stroke. Understanding brain atrophy at the network level may be key to clarifying healthy aging processes and the pathway to neurodegeneration after stroke.
The Impact of a Multi-Level Multi-Component Childhood Obesity Prevention Intervention on Healthy Food Availability, Sales, and Purchasing in a Low-Income Urban Area
Authors: Gittelsohn Joel , Trude Angela , Poirier Lisa , Ross Alexandra , Ruggiero Cara , Schwendler Teresa , Anderson Steeves Elizabeth
Published: November 2017

The multifactorial causes of obesity require multilevel and multicomponent solutions, but such combined strategies have not been tested to improve the community food environment. We evaluated the impact of a multilevel (operating at different levels of the food environment) multicomponent (interventions occurring at the same level) community intervention. The B’more Healthy Communities for Kids (BHCK) intervention worked at the wholesaler (n = 3), corner store (n = 50), carryout (n = 30), recreation center (n = 28), household (n = 365) levels to improve availability, purchasing, and consumption of healthier foods and beverages (low-sugar, low-fat) in low-income food desert predominantly African American zones in the city of Baltimore (MD, USA), ultimately intending to lead to decreased weight gain in children (not reported in this manuscript). For this paper, we focus on more proximal impacts on the food environment, and measure change in stocking, sales and purchase of promoted foods at the different levels of the food system in 14 intervention neighborhoods, as compared to 14 comparison neighborhoods. Sales of promoted products increased in wholesalers. Stocking of these products improved in corner stores, but not in carryouts, and we did not find any change in total sales. Children more exposed to the intervention increased their frequency of purchase of promoted products, although improvement was not seen for adult caregivers. A multilevel food environment intervention in a low-income urban setting improved aspects of the food system, leading to increased healthy food purchasing behavior in children.
Infection of a French Population of Aedes albopictus and of Aedes aegypti (Paea Strain) with Zika Virus Reveals Low Transmission Rates to These Vectors’ Saliva
Authors: Ryckebusch Faustine , Berthet Michèle , Missé Dorothée , Choumet Valérie
Published: November 2017

Disease caused by the Zika virus (ZIKV) is a public health emergency of international concern. Recent epidemics have emerged in different regions of the world and attest to the ability of the virus to spread wherever its vector, Aedes species mosquitoes, can be found. We have compared the transmission of ZIKV by Ae. aegypti (PAEA strain originating from Tahiti) and by a French population of Ae. albopictus to better assess their competence and the potential risk of the emergence of ZIKV in Europe. We assessed the transmission of ZIKV by Ae. albopictus in temperatures similar to those in Southern France during the summer. Our study shows that the extrinsic incubation period of Ae. aegypti for transmission was shorter than that of Ae. albopictus. Both vectors were able to transmit ZIKV from 10 to 14 days post-infection. Ae. aegypti, however, had a longer transmission period than the French population of Ae. albopictus. Although the salivary glands of both vectors are highly infected, transmission rates of ZIKV to saliva remain relatively low. These observations may suggest that the risk of emergence of ZIKV in Europe could be low.
A New Maraging Stainless Steel with Excellent Strength–Toughness–Corrosion Synergy
Authors: Tian Jialong , Wang Wei , Babar Shahzad M. , Yan Wei , Shan Yiyin , Jiang Zhouhua , Yang Ke
Published: November 2017

A new maraging stainless steel with superior strength–toughness–corrosion synergy has been developed based on an innovative concept of alloy design. The high strength–toughness combination is achieved by forming dispersive nano-sized intermetallic compounds in the soft lath martensitic matrix with a slight amount of residual austenite. The good corrosion resistance is guaranteed by exactly controlling the Co content based on understanding the synergistic effect between Co and Cr. The fine structure characteristics of two dominant strengthening precipitations including Ni3Ti and Mo-rich phases were finely characterized associated with transmission electron microscope (TEM) and atom probe tomography (APT) analyses. The relationship among microstructure, strength and toughness is discussed. The precipitation mechanism of different precipitates in the new maraging stainless steel is revealed based on the APT analysis.
Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review
Authors: Shah Sayed , Akhter Najeeb , Auckloo Bibi , Khan Ishrat , Lu Yanbin , Wang Kuiwu , Wu Bin , Guo Yue-Wei
Published: November 2017

Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increase in the number of deaths caused by cancer due to chemotherapy resistance as well. Accordingly, marine cyanobacteria, being the oldest prokaryotic microorganisms belonging to a monophyletic group, have proven themselves as being able to generate pharmaceutically important natural products. They have long been known to produce distinct and structurally complex secondary metabolites including peptides, polyketides, alkaloids, lipids, and terpenes with potent biological properties and applications. As such, this review will focus on recently published novel compounds isolated from marine cyanobacteria along with their potential bioactivities such as antibacterial, antifungal, anticancer, anti-tuberculosis, immunosuppressive and anti-inflammatory capacities. Moreover, various structural classes, as well as their technological uses will also be discussed.
Preparation of Direct Reduced Iron and Titanium Nitride from Panzhihua Titanomagnetite Concentrate Through Carbothermic Reduction-Magnetic Separation
Authors: Yu Wen , Wen Xiaojin , Chen Jiangan , Kuang Jingzhong , Tang Qiongyao , Tian Yuechao , Fu Jiali , Huang Weiqin , Qiu Tingsheng
Published: November 2017

A novel process for preparing direct reduction iron (DRI) and titanium nitride (TiN) from Panzhihua titanomagnetite concentrate is proposed. This process involves pelletizing, direct reduction roasting and magnetic separation. The effects of reduction temperature, coal dosage and reduction time on the phase transformation of composite pellets were investigated by X-ray diffraction. Results show that TiN formation proceeds less easily than metallic iron formation. Increasing the reduction temperature, reduction time and coal dosage can promote the transformation of titanium to TiN. Titanium was almost completely transformed into TiN under the conditions of 1300 °C reduction temperature, 26 wt % coal dosage and 90 min reduction time. The scanning electron microscopy (SEM) analysis showed that near-spherical metallic iron particles with diameters from dozens of microns to about 300 μm were formed in the reduced pellets, whereas the TiN particles generally measured less than 10 μm. The energy dispersive spectroscopy (EDS) results revealed that the TiN phase contains a certain amount of vanadium and carbon, and traces of other impurities. The reduced composite pellets under the optimum conditions were processed by grinding and subsequent magnetic separation. As a result, a DRI with 92.88 wt % Fe, 1.00 wt % Ti, and 0.13 wt % V was obtained, and the recoveries of Fe, Ti, and V were 92.85 wt %, 9.00 wt %, and 19.40 wt %, respectively. 91.00 wt % Ti and 80.60 wt % V were concentrated in the rough TiN concentrate.
Soft-Template Synthesis of Mesoporous Anatase TiO2 Nanospheres and Its Enhanced Photoactivity
Authors: Li Xiaojia , Zou Mingming , Wang Yang
Published: November 2017

Highly crystalline mesoporous anatase TiO2 nanospheres with high surface area (higher than P25 and anatase TiO2) are prepared by a soft-template method. Despite the high specific surface area, these samples have three times lower equilibrium adsorption (<2%) than Degussa P25. The rate constant of the mesoporous anatase TiO2 (0.024 min−1) reported here is 364% higher than that of P25 (0.0066 min−1), for the same catalytic loading. The results of oxidation-extraction photometry using several reactive oxygen species (ROS) scavengers indicated that mesoporous anatase TiO2 generates more ROS than P25 under UV-light irradiation. This significant improvement in the photocatalytic performance of mesoporous spherical TiO2 arises from the following synergistic effects in the reported sample: (i) high surface area; (ii) improved crystallinity; (iii) narrow pore wall thicknesses (ensuring the rapid migration of photogenerated carriers to the surface of the material); and (iv) greater ROS generation under UV-light.
The Blood-Brain Barrier Permeability of Six Indole Alkaloids from Uncariae Ramulus Cum Uncis in the MDCK-pHaMDR Cell Monolayer Model
Authors: Zhang Yi-Nan , Yang Yan-Fang , Xu Wei , Yang Xiu-Wei
Published: November 2017

Uncariae Ramulus Cum Uncis (URCU) is a widely used traditional Chinese medicine, and is reported to have various central nervous system effects. Alkaloids have been demonstrated to be the predominant pharmacological active components of URCU. In order to evaluate the blood-brain barrier (BBB) permeability and transport mechanism of six typical indole alkaloids from URCU, the MDCK-pHaMDR cell monolayer model was used as an in vitro surrogate model for BBB. The samples were analyzed by high-performance liquid chromatography, and the apparent permeability coefficients (Papp) were calculated. Among the six alkaloids, isorhynchophylline (2), isocorynoxeine (4), hirsutine (5) and hirsuteine (6) showed high permeability, with Papp values at 10−5 cm/s level in bidirectional transport. For rhynchophylline (1) and corynoxeine (3), they showed moderate permeability, with Papp values from the apical (AP) side to the basolateral (BL) side at 10−6 cm/s level and efflux ratio (Papp BL→AP/Papp AP→BL) above 2. The time- and concentration-dependency experiments indicated that the main mechanism for 2, 4, 5 and 6 through BBB was passive diffusion. The efflux mechanism involved in the transports of compounds 1 and 3 could be reduced significantly by verapamil, and molecular docking screening also showed that 1 and 3 had strong bindings to P-glycoprotein. This study provides useful information for predicting the BBB permeability for 1–6, as well as better understanding of their central nervous system pharmacological activities.
Slowly Digestible Carbohydrate for Balanced Energy: In Vitro and In Vivo Evidence
Authors: Gourineni Vishnupriya , Stewart Maria , Skorge Rob , Sekula Bernard
Published: November 2017

There is growing interest among consumers in foods for sustained energy management, and an increasing number of ingredients are emerging to address this demand. The SUSTRA™ 2434 slowly digestible carbohydrate is a blend of tapioca flour and corn starch, with the potential to provide balanced energy after a meal. The aim of the study was to characterize this starch’s digestion profile in vitro (modified Englyst assay) and in vivo (intact and cecectomized rooster study), and to determine its effects on available energy, by measuring post-prandial glycemia in healthy adults (n = 14), in a randomized, double-blind, placebo-controlled, cross-over study, with two food forms: cold-pressed bar and pudding. The in vitro starch digestion yielded a high slowly digestible fraction (51%) compared to maltodextrin (9%). In the rooster digestibility model, the starch was highly digestible (94%). Consumption of slowly digestible starch (SDS), in an instant pudding or bar, yielded a significantly lower glycemic index compared to a control. At individual time points, the SDS bar and pudding yielded blood glucose levels with significantly lower values at 30–60 min and significantly higher values at 120–240 min, demonstrating a balanced energy release. This is the first study to comprehensively characterize the physiological responses to slowly digestible starch (tapioca and corn blend) in in vitro and in vivo studies.
Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies
Authors: Yousef Michael , Vlachogiannis Ioannis , Tsiani Evangelia
Published: November 2017

Uncontrolled cell growth and resistance to apoptosis characterize cancer cells. These two main features are initiated in cancer cells through mutations in key signaling molecules, which regulate pathways that are directly involved in controlling cell proliferation and apoptosis. Resveratrol (RSV), a naturally occurring plant polyphenol, has been shown to have biological effects counteracting different diseases. It has been found to provide cardio-protective, neuro-protective, immuno-modulatory, and anti-cancer health benefits. RSV has been found to inhibit cancer cell proliferation, induce cell cycle arrest and apoptosis, and these anticancer effects may be due to its ability to modulate signaling molecules involved in these processes. The present review summarizes the existing in vitro and in vivo studies on resveratrol and its anti-lung cancer properties.
Blood Compatibility of ZrO2 Particle Reinforced PEEK Coatings on Ti6Al4V Substrates
Authors: Song Jian , Liao Zhenhua , Shi Hongyu , Xiang Dingding , Xu Lin , Liu Yuhong , Mu Xiaohong , Liu Weiqiang
Published: November 2017

Titanium (Ti) and its alloys are widely used in biomedical devices. As biomaterials, the blood compatibility of Ti and its alloys is important and needs to be further improved to provide better functionality. In this work, we studied the suitability of zirconia (ZrO2) particle reinforced poly-ether-ether-ketone (PEEK) coatings on Ti6Al4V substrates for blood-contacting implants. The wettability, surface roughness and elastic modulus of the coatings were examined. Blood compatibility tests were conducted by erythrocytes observation, hemolysis assay and clotting time of recalcified human plasma, to find out correlations between the microstructure of the ZrO2-filled PEEK composite coatings and their blood compatibilities. The results suggested that adding ZrO2 nanoparticles increased the surface roughness and improved the wettability and Derjaguin-Muller-Toporov (DMT) elastic modulus of PEEK coating. The PEEK composite matrix coated Ti6Al4V specimens did not cause any aggregation of erythrocytes, showing morphological normal shapes. The hemolysis rate (HR) values of the tested specimens were much less than 5% according to ISO 10993-4 standard. The values of plasma recalcification time (PRT) of the tested specimens varied with the increasing amount of ZrO2 nanoparticles. Based on the results obtained, 10 wt % ZrO2 particle reinforced PEEK coating has demonstrated an optimum blood compatibility, and can be considered as a candidate to improve the performance of existing PEEK based coatings on titanium substrates.
Forest Types Classification Based on Multi-Source Data Fusion
Authors: Lu Ming , Chen Bin , Liao Xiaohan , Yue Tianxiang , Yue Huanyin , Ren Shengming , Li Xiaowen , Nie Zhen , Xu Bing
Published: November 2017

Forest plays an important role in global carbon, hydrological and atmospheric cycles and provides a wide range of valuable ecosystem services. Timely and accurate forest-type mapping is an essential topic for forest resource inventory supporting forest management, conservation biology and ecological restoration. Despite efforts and progress having been made in forest cover mapping using multi-source remotely sensed data, fine spatial, temporal and spectral resolution modeling for forest type distinction is still limited. In this paper, we proposed a novel spatial-temporal-spectral fusion framework through spatial-spectral fusion and spatial-temporal fusion. Addressing the shortcomings of the commonly-used spatial-spectral fusion model, we proposed a novel spatial-spectral fusion model called the Segmented Difference Value method (SEGDV) to generate fine spatial-spectra-resolution images by blending the China environment 1A series satellite (HJ-1A) multispectral image (Charge Coupled Device (CCD)) and Hyperspectral Imager (HSI). A Hierarchical Spatiotemporal Adaptive Fusion Model (HSTAFM) was used to conduct spatial-temporal fusion to generate the fine spatial-temporal-resolution image by blending the HJ-1A CCD and Moderate Resolution Imaging Spectroradiometer (MODIS) data. The spatial-spectral-temporal information was utilized simultaneously to distinguish various forest types. Experimental results of the classification comparison conducted in the Gan River source nature reserves showed that the proposed method could enhance spatial, temporal and spectral information effectively, and the fused dataset yielded the highest classification accuracy of 83.6% compared with the classification results derived from single Landsat-8 (69.95%), single spatial-spectral fusion (70.95%) and single spatial-temporal fusion (78.94%) images, thereby indicating that the proposed method could be valid and applicable in forest type classification.
Ship-Iceberg Discrimination in Sentinel-2 Multispectral Imagery by Supervised Classification
Authors: Heiselberg Peder , Heiselberg Henning
Published: November 2017

The European Space Agency Sentinel-2 satellites provide multispectral images with pixel sizes down to 10 m. This high resolution allows for fast and frequent detection, classification and discrimination of various objects in the sea, which is relevant in general and specifically for the vast Arctic environment. We analyze several sets of multispectral image data from Denmark and Greenland fall and winter, and describe a supervised search and classification algorithm based on physical parameters that successfully finds and classifies all objects in the sea with reflectance above a threshold. It discriminates between objects like ships, islands, wakes, and icebergs, ice floes, and clouds with accuracy better than 90%. Pan-sharpening the infrared bands leads to classification and discrimination of ice floes and clouds better than 95%. For complex images with abundant ice floes or clouds, however, the false alarm rate dominates for small non-sailing boats.
An Investigation into Spike-Based Neuromorphic Approaches for Artificial Olfactory Systems
Authors: Vanarse Anup , Osseiran Adam , Rassau Alexander
Published: November 2017

The implementation of neuromorphic methods has delivered promising results for vision and auditory sensors. These methods focus on mimicking the neuro-biological architecture to generate and process spike-based information with minimal power consumption. With increasing interest in developing low-power and robust chemical sensors, the application of neuromorphic engineering concepts for electronic noses has provided an impetus for research focusing on improving these instruments. While conventional e-noses apply computationally expensive and power-consuming data-processing strategies, neuromorphic olfactory sensors implement the biological olfaction principles found in humans and insects to simplify the handling of multivariate sensory data by generating and processing spike-based information. Over the last decade, research on neuromorphic olfaction has established the capability of these sensors to tackle problems that plague the current e-nose implementations such as drift, response time, portability, power consumption and size. This article brings together the key contributions in neuromorphic olfaction and identifies future research directions to develop near-real-time olfactory sensors that can be implemented for a range of applications such as biosecurity and environmental monitoring. Furthermore, we aim to expose the computational parallels between neuromorphic olfaction and gustation for future research focusing on the correlation of these senses.
A Pneumatic Tactile Sensor for Co-Operative Robots
Authors: Gong Daoxiong , He Rui , Yu Jianjun , Zuo Guoyu
Published: November 2017

Tactile sensors of comprehensive functions are urgently needed for the advanced robot to co-exist and co-operate with human beings. Pneumatic tactile sensors based on air bladder possess some noticeable advantages for human-robot interaction application. In this paper, we construct a pneumatic tactile sensor and apply it on the fingertip of robot hand to realize the sensing of force, vibration and slippage via the change of the pressure of the air bladder, and we utilize the sensor to perceive the object’s features such as softness and roughness. The pneumatic tactile sensor has good linearity, repeatability and low hysteresis and both its size and sensing range can be customized by using different material as well as different thicknesses of the air bladder. It is also simple and cheap to fabricate. Therefore, the pneumatic tactile sensor is suitable for the application of co-operative robots and can be widely utilized to improve the performance of service robots. We can apply it to the fingertip of the robot to endow the robotic hand with the ability to co-operate with humans and handle the fragile objects because of the inherent compliance of the air bladder.
Review of Recent Inkjet-Printed Capacitive Tactile Sensors
Authors: Salim Ahmed , Lim Sungjoon
Published: November 2017

Inkjet printing is an advanced printing technology that has been used to develop conducting layers, interconnects and other features on a variety of substrates. It is an additive manufacturing process that offers cost-effective, lightweight designs and simplifies the fabrication process with little effort. There is hardly sufficient research on tactile sensors and inkjet printing. Advancements in materials science and inkjet printing greatly facilitate the realization of sophisticated tactile sensors. Starting from the concept of capacitive sensing, a brief comparison of printing techniques, the essential requirements of inkjet-printing and the attractive features of state-of-the art inkjet-printed tactile sensors developed on diverse substrates (paper, polymer, glass and textile) are presented in this comprehensive review. Recent trends in inkjet-printed wearable/flexible and foldable tactile sensors are evaluated, paving the way for future research.
A Study on a Control Method with a Ventilation Requirement of a VAV System in Multi-Zone
Authors: Kim Hyo-Jun , Cho Young-Hum
Published: November 2017

The objective of this study was to propose a control method with a ventilation requirement of variable air volume (VAV) system in multi-zone. In order to control the VAV system inmulti-zone, it is essential to control the terminal unit installed in each zone. A VAV terminal unit with conventional control method using a fixed minimum air flow can cause indoor air quality (IAQ) issues depending on the variation in the number of occupants. This research proposes a control method with a ventilation requirement of the VAV terminal unit and AHU inmulti-zone. The integrated control method with an air flow increase model in the VAV terminal unit, AHU, and outdoor air intake rate increase model in the AHU was based on the indoor CO2 concentration. The conventional and proposed control algorithms were compared through a TRNSYS simulation program. The proposed VAV terminal unit control method satisfies all the conditions of indoor temperature, IAQ, and stratification. An energy comparison with the conventional control method showed that the method satisfies not only the indoor thermal comfort, IAQ, and stratification issue, but also reduces the energy consumption.
Real-Time Monitoring System Using Smartphone-Based Sensors and NoSQL Database for Perishable Supply Chain
Authors: Alfian Ganjar , Syafrudin Muhammad , Rhee Jongtae
Published: November 2017

Since customer attention is increasing due to growing customer health awareness, it is important for the perishable food supply chain to monitor food quality and safety. This study proposes a real-time monitoring system that utilizes smartphone-based sensors and a big data platform. Firstly, we develop a smartphone-based sensor to gather temperature, humidity, GPS, and image data. The IoT-generated sensor on the smartphone has characteristics such as a large amount of storage, an unstructured format, and continuous data generation. Thus, in this study, we propose an effective big data platform design to handle IoT-generated sensor data. Furthermore, the abnormal sensor data generated by failed sensors is called outliers and may arise in real cases. The proposed system utilizes outlier detection based on statistical and clustering approaches to filter out the outlier data. The proposed system was evaluated for system and gateway performance and tested on the kimchi supply chain in Korea. The results showed that the proposed system is capable of processing a massive input/output of sensor data efficiently when the number of sensors and clients increases. The current commercial smartphones are sufficiently capable of combining their normal operations with simultaneous performance as gateways for transmitting sensor data to the server. In addition, the outlier detection based on the 3-sigma and DBSCAN were used to successfully detect/classify outlier data as separate from normal sensor data. This study is expected to help those who are responsible for developing the real-time monitoring system and implementing critical strategies related to the perishable supply chain.
A New Multi-Attribute Decision-Making Method Based on m-Polar Fuzzy Soft Rough Sets
Authors: Akram Muhammad , Ali Ghous , Alshehri Noura
Published: November 2017

We introduce notions of soft rough m-polar fuzzy sets and m-polar fuzzy soft rough sets as novel hybrid models for soft computing, and investigate some of their fundamental properties. We discuss the relationship between m-polar fuzzy soft rough approximation operators and crisp soft rough approximation operators. We also present applications of m-polar fuzzy soft rough sets to decision-making.
Function-Oriented Networking and On-Demand Routing System in Network Using Ant Colony Optimization Algorithm
Authors: Sim Young-Bo , Lee SeungGwan , Lee Sungwon
Published: November 2017

In this paper, we proposed and developed Function-Oriented Networking (FON), a platform for network users. It has a different philosophy as opposed to technologies for network managers of Software-Defined Networking technology, OpenFlow. It is a technology that can immediately reflect the demands of the network users in the network, unlike the existing OpenFlow and Network Functions Virtualization (NFV), which do not reflect directly the needs of the network users. It allows the network user to determine the policy of the direct network, so it can be applied more precisely than the policy applied by the network manager. This is expected to increase the satisfaction of the service users when the network users try to provide new services. We developed FON function that performs on-demand routing for Low-Delay Required service. We analyzed the characteristics of the Ant Colony Optimization (ACO) algorithm and found that the algorithm is suitable for low-delay required services. It was also the first in the world to implement the routing software using ACO Algorithm in the real Ethernet network. In order to improve the routing performance, several algorithms of the ACO Algorithm have been developed to enable faster path search-routing and path recovery. The relationship between the network performance index and the ACO routing parameters is derived, and the results are compared and analyzed. Through this, it was possible to develop the ACO algorithm.
Antibody Competition Reveals Surface Location of HPV L2 Minor Capsid Protein Residues 17–36
Authors: Bywaters Stephanie , Brendle Sarah , Tossi Kerstin , Biryukov Jennifer , Meyers Craig , Christensen Neil
Published: November 2017

The currently available nonavalent human papillomavirus (HPV) vaccine exploits the highly antigenic L1 major capsid protein to promote high-titer neutralizing antibodies, but is limited to the HPV types included in the vaccine since the responses are highly type-specific. The limited cross-protection offered by the L1 virus-like particle (VLP) vaccine warrants further investigation into cross-protective L2 epitopes. The L2 proteins are yet to be fully characterized as to their precise placement in the virion. Adding to the difficulties in localizing L2, studies have suggested that L2 epitopes are not well exposed on the surface of the mature capsid prior to cellular engagement. Using a series of competition assays between previously mapped anti-L1 monoclonal antibodies (mAbs) (H16.V5, H16.U4 and H16.7E) and novel anti-L2 mAbs, we probed the capsid surface for the location of an L2 epitope (aa17–36). The previously characterized L1 epitopes together with our competition data is consistent with a proposed L2 epitope within the canyons of pentavalent capsomers.
Does International Travel Boost One's Interest in Foreign Policy? Attitude Change Among Tourists
Authors: Carder Kevin , Machida Satoshi
Published: November 2017

The purpose of this study is to examine the process through which people develop their interest in global issues. More specifically, this study examines how people's traveling experiences affect their views on the importance of foreign policy. Consistent with the "intergroup contact
theory," we hypothesize that exposure to foreign cultures boosts people's interest in foreign policy, because traveling involves direct interactions with people from different backgrounds. In order to examine our hypotheses, we conducted an online survey among more than 1,000 adults living
in the US. The results of the OLS analyses show that traveling enhances people's recognition of foreign affairs as an important issue. Dissecting the impact of traveling on people's interest in foreign policy, this study makes an important contribution to the literature, with implications
that are highly relevant in the era of globalization.