bluuebunny/crossref_metadata_2025 huggingface dataset:
Religious Moderation in Indonesia: A Study on Implementation Patterns of the Indonesian Ulema Council (MUI)
Authors: Pagar Pagar , Akhyar Syaiful , Tunip Ibnu Radwan Siddik
Published: January 2024

As a symbol of ulema which is the main tent of Muslims in Indonesia, the Indonesian Ulema Council (MUI) is certainly expected to be able to implement the concept of religious moderation. This paper aims to examine the implementation of MUI religious moderation in Indonesia. Then, this study also aims to discuss how the pattern of implementation of MUI religious moderation towards Muslims, deviant religious beliefs, non-Muslims, and the government. This is qualitative research with a participatory action research (PAR) approach. Informants involved as subjects and objects in this study were structural scholars, academic scholars, and community scholars in the provinces of DKI Jakarta, North Sumatra, and Aceh. The results of the study indicate that the implementation of MUI religious moderation in Indonesia has been implemented well. MUI is responsive and accommodating to the needs of the community, especially Muslims, and plays a very important role in creating a safe and peaceful atmosphere in the community. However, some people consider that the application of MUI's religious moderation values to groups that are considered deviant (heretic) and non-Muslims has not run optimally. This can be seen with the issuance of the MUI fatwa on the expectation of the existence of pluralism, liberalism, and religious secularism. MUI is expected to further improve the pattern of its relationship with the two community groups. Meanwhile, towards the government, MUI positions itself as a critical partner of the government (syarikatul hukumah). MUI sometimes supports government programs, but it can also disagree with government programs as outlined through MUI fatwas that seem contrary to the interests of the government,such as fatwas against vasectomy and fatwas on the use of meningitis vaccines for pilgrims or umrah.
Critical Role of Agrarian Reform in Development National in Indonesia
Authors: Yahman Yahman
Published: January 2024

This research aims to analyze the Critical Role of Agrarian Reform in National Development in Indonesia. This research method is normative; namely, research focused on assessing the application of rules or norms in positive law. By using a statutory approach (statute approach) is an approach that is taken by examining the standards contained in statutory provisions. The primary material sources used in this study are the 1945 Constitution of the Republic of Indonesia (1945 Constitution), Law Number 5 of 1960 concerning Basic Agrarian Regulations (UUPA), and MPR RI Decree No. IX/MPR/2001 concerning Agrarian Reform and Natural Resource Management (TAP MPR RI No. IX/MPR/2001), and Presidential Regulation of the Republic of Indonesia Number 86 of 2018 concerning Agrarian Reform (Perpres 86/2018). While the secondary legal materials used by the author are publications in the field of law but not official documents, namely: books, journals, and comments. The study results concluded that Agrarian Reform aimed to rearrange the existing order in society so that people could feel justice and equity in the land sector. In carrying out agrarian reform, there are several stages, namely the establishment of a committee at the autonomous regional level, which is tasked with registering land ownership that exceeds the maximum limit and whose goal is people's welfare, legal certainty, and justice. However, in its development, the implementation of agrarian reform experienced obstacles that caused the main objectives of agricultural reform not to be achieved, so a rural reform arrangement was needed to be aimed at the prosperity of the people.
The Role Of A Notary In Preventing Money Laundering
Authors: Dharsana I Made Pria , Kresnadjaja Indrasari , Dhananjaya I Putu Lingga , Rini Rizky Mustika
Published: January 2024

The Notary's participation in preventing money laundering is to report to PPATK when they know of suspicious financial transactions related to the deed they made. The Notary's position as a whistleblower in the event of suspected suspicious financial transactions as an effort to prevent money laundering has not violated the principle of confidentiality of position. Instead, the Notary must apply the precautionary principle. Notary as the reporting party is an implementation of its obligations stipulated in Article 16 paragraph (1) point an of UUJN, namely acting trustfully and honestly. The State appoints notaries to serve the public in civil Law. Therefore Notaries must also take care not to let the State be harmed by attempts to disguise money from criminal acts. Notaries with this submit to higher interests. This is so that Notaries do not get involved in money laundering cases because they are considered to help carry out a criminal act
Vertical Land Consolidation For Handling Urban Housing And Slum Settlement Arrangements
Authors: Nurmawati Bernadete , Herman KMS , Iryani Dewi , Darmawansyah Adi , Butarbutar Russel
Published: January 2024

The proliferation of slums in cities with limited land availability calls for regulation on how best to utilize and control Land and initiatives to streamline and improve land use in metropolitan areas through land consolidation. Therefore, the government can use land consolidation to ensure the quality of the urban environment and the social functions of Land. Land consolidation itself is mainly carried out on city properties due to the high concentration of people and lack of planning that characterizes many urban environments. In urban slum programs, vertical land consolidation is an alternative land supply to reorganize slums. By reorganizing who owns what, where it can be used, and how it can be used, land consolidation is carried out to enhance natural resource conservation and improve environmental quality through community involvement and public use of previously privately owned Land. Community participation is a major part of the framework for improving the quality and quantity of land functions. Vertical land consolidation can serve as a useful solution to urban problems such as housing affordability and density. By consolidating Land vertically, more housing units can be built in a smaller area, providing more affordable housing options for residents. In addition, vertical land consolidation helps reduce urban sprawl and results in more sustainable and livable cities. This paper uses normative legal research techniques, including research into applying positive law and legal principles or norms.
Istinbath Method in Strengthening Ultra Qui Judicial Principles in Judicial Decisions
Authors: Imran Suwitno Yutye , Apripari Apripari , Ishwara Ade Sathya Sanathana , Churniawan Erifendi , Jaya Aristama Mega , Nurikah Nurikah
Published: January 2024

the method of Istinbath is necessary to support the principle of Ultra Qui Judicat, enabling judges to possess moral characteristics in considering not only knowledge and reason but also Islamic law when making legal decisions. Overall, the significance of the Istinbath method in supporting the principle of Ultra Qui Judicat is paramount, especially in addressing contemporary and empirical issues not governed by legislative regulations. The aim of this research are : explain the concept of Istinbath and Ultra Qui Judicat influence the judge's decisions and the application of the Istinbath method used to reinforce the principle of Ultra Qui Judicat to judicial decisions. The result shows that The method of Istinbath is closely related to the principle of Ultra Qui Judicat since both share the same objective of achieving justice. In practice, judges can use the method of Istinbath to interpret the law and apply the principle of Ultra Qui Judicat in criminal cases. The principle of Ultra Qui Judicat and the method of Istinbath are essential instruments for judges in the criminal justice system to achieve justice in decision-making
THE POLICY OF BANNING THE EXPORT OF RAW MATERIALS IN THE MINING SECTOR BY THE INDONESIAN GOVERNMENT FROM THE PERSPECTIVE OF INTERNATIONAL TRADE LAW
Authors: P.M. Hilton Tarnama , Marpudin Ade , Mega Jaya Belardo Prasetya
Published: January 2024

The management and utilization of natural resources by a country are manifestations of exercising national sovereignty. The Doctrine of Sovereignty is designed to provide equality among nations under the law to develop their countries towards prosperity and well-being. The policy of restricting and prohibiting the export of raw materials in the mining sector, such as nickel, gold, and tin, by the Indonesian government, is recognized under international law, particularly international trade law. This policy will bring beneficial impacts to Indonesia's economy. By having the capability to process natural resources independently, Indonesia can enhance its economic self-reliance, reduce dependency on imports, and improve the country's position in the global competition in the mining sector, ultimately leading to increased national revenue and providing greater well-being for the entire Indonesian population.
THE PARADIGM OF LAW AS A SOCIAL ENGINEERING IN THE EXISTENCE OF CRYPTO ASSET MONITORING: WHAT AND HOW?
Authors: Basworo Handityo
Published: January 2024

The development of transactions through crypto assets is one of the practices carried out in the digital business world. The existence of transactions through crypto assets makes the state regulate and supervise crypto assets. One of the legal policies carried out by the state is to supervise crypto asset transactions by the OJK institution. This study aims to answer two legal issues, namely the implications of regulating crypto asset supervision after the passing of the Law No. 4 of 2023 on Financial Sector Development and Strengthening (PPSK Law) and the orientation of crypto asset supervision after the passing of the PPSK Law from a law perspective as a tool of social engineering. This research is normative legal research by prioritizing conceptual and statutory approaches. The results of the study confirm that the implications of supervising crypto assets after that is to make the existence and position of CoFTRA as a supervisor of transactions using crypto assets increasingly lead to ambiguity because the authority regarding the supervision of crypto assets becomes the authority of the OJK. The orientation of oversight of crypto assets in the perspective of law as a social engineering can be seen that the substance of oversight of crypto assets by the OJK aims to carry out community engineering, namely in the form of future efforts so that the community can optimize crypto asset transactions to increase the strengthening of national finance and to give the public a sense of security for transactions crypto assets carried out, the state took the initiative to formulate oversight of crypto assets by OJK because OJK is considered the right and appropriate institution in efforts to regulate and supervise crypto asset transactions.
Existence of Registered/Unregistered Marriage Clauses in Family Cards from a Family Law Perspective
Authors: Febrianty Yenny , Sulastri Sulastri , Zulfiani Zulfiani
Published: January 2024

Family plays a central role in maintaining the stability and continuity of a nation, and marriage is the primary foundation for forming a legally recognized family. The Family Card records marital status and holds a crucial role in family administration and the legal rights of family members. However, practices in the field often do not align with the rules of recording marriages in the Family Card. This research aims to examine the influence of marriage clauses in the Family Card on the legal status of marriage from the perspective of family law, as well as its impacts in the social context. Using a normative legal research method, with a legislative approach and data from relevant legal documents, this study contributes to understanding and addressing family law issues in Indonesia while adapting to the diverse social and religious realities of the community. The research findings show that recording marriage in the Family Card has a significant impact from the perspective of family law in Indonesia. Recorded status in the Family Card provides legal certainty, better legal protection, and easier access to rights and benefits. Conversely, "Not Recorded" status can create legal uncertainty, obstacles in obtaining rights and benefits, and a higher risk of legal consequences in divorce and inheritance rights. The social impacts of the existence of marriage clauses recorded or not recorded in the Family Card are diverse. Recorded marriages create positive social recognition, family support, and easier access to social programs, while unrecorded marriages can result in social stigma, discrimination, and uncertainty regarding the rights of children born from such marriages.
GOOD FAITH AS A BASIS FOR CONSUMER LIABILITY IN CASH ON DELIVERY (COD) TRANSACTIONS
Authors: Admiral Admiral , Seruni Puti Mayang , Febrianto Surizki
Published: January 2024

Cash on Delivery (COD) is a popular type of transaction in online buying and selling. However, the implementation of the COD feature creates the issue of consumers being reluctant to make payments after the goods have come as agreed. This unilateral cancellation may result in losses for the seller, the application, and the courier. The aim of this research is to examine the legal liabilities of consumers who make unilateral cancellations to prevent losses. This is normative research that employs secondary data from primary, secondary, and tertiary legal materials. The gathered data is then qualitatively analyzed and related with the core problem. According to the findings, the agreement must be made in good faith, which can be defined as subjective good faith (honesty) and objective good faith (propriety and justice) under Article 1338 paragraph 3 of the Civil Code. Judges have the right to evaluate an agreement and terminate it if it contains improper or unfair details.  Before the transaction, where the seller and buyer must be honest, good faith plays a significant part in online transactions using the COD method. Buyers are expected to carefully study the description of the items to be purchased because placing an order indicates that the buyer has agreed to the specifications of the goods and will pay when the goods are received. The COD payment method does not allow customers to cancel unilaterally without providing clear reasons and is therefore considered a default
Harship Doctrine Regarding Fulfillment of the Performance of an Agreement
Authors: Cahayani Dian
Published: January 2024

In contract law, performance fulfillment is a fundamental principle. However, in practice, unforeseen changes in circumstances can disrupt performance fulfillment. To address this, the doctrine of hardship is necessary to create a balance between performance fulfillment and unforeseen changes in circumstances. The aim of this research is to analyze the concept of the hardship doctrine in contract law and identify its impact on the interpretation and performance of contracts, as well as the protection of rights and fairness for parties bound by contractual agreements. The research method used is normative research method with a focus on analyzing the legal regulations that govern the hardship doctrine. The data sources include legal texts, regulations, court decisions, and relevant legal expert opinions, along with techniques such as legal document analysis, comparison, and drawing conclusions to generate a comprehensive understanding. In contract law, the hardship doctrine refers to the concept of unforeseen changes in circumstances significantly affecting contract performance. This doctrine allows parties to request contract modifications or terminations in situations that are no longer fair or feasible. It also impacts contract interpretation, as courts determine whether the changed circumstances meet the criteria for activating the doctrine. Although not fully regulated in Indonesian legislation, the Civil Code provides relevant legal grounds. It is important for contracting parties to understand the implications of the hardship doctrine and consider its inclusion in their agreements. The doctrine plays a crucial role in protecting the rights and ensuring fairness to parties bound by contractual agreements in Indonesia. It provides protection, flexibility, and considerations for social impact and public interests. However, its use should be limited, meet strict requirements, and align with applicable laws. Therefore, the hardship doctrine serves as an essential tool to maintain balance and justice in contract performance when used carefully and in compliance with relevant conditions.  
The Problematic of Cashless In The Society 5.0 Era on the Workforce in Makassar City: What Should It Be?
Authors: Juwenie Juwenie , Wakey Christo Paulus Moningka , Tongchangya Novin Kanti
Published: January 2024

The aim of this research is to analyze the problems and legal protection efforts for workers who have been replaced by cashless in the Era of Society 5.0 in Makassar City, which is related to the existence of a legal vacuum related to regulations regarding facilitation and guidance efforts from the Makassar City Government to be able to empower local Makassar workers in this era of development. technology. This research is normative legal research with a conceptual and statutory approach. The results of the research confirm that the problem of using cashless in the era of society 5.0 for workers in Makassar City, namely the reduction in the number of workers working in various companies who were previously officers where cash payments were made, means that the government must have policies and strategies to provide guaranteed rights for workers. whose position has been replaced as a result of the practice of cashless-based electronic or non-cash transactions. Preventive legal protection can be carried out by establishing statutory regulations, especially at the regional level which are oriented towards empowering the local Makassar workforce so that they can have certain skills and expertise in the era of technological development. In terms of protecting repressive laws, there is a need for an active role from related agencies in Makassar City, especially efforts to provide special guidance and education for local Makassar workers so that they can have certain skills and expertise in the era of technological development.
LEGAL IMPLICATIONS OF CULTIVATION RIGHT ISSUED ON MINING BUSINESS PERMIT (Case Study of Issuance of Cultivation Right Certificate Number: 00090/Bangka on Behalf of GUNUNG PELAWAN LESTARI (GPL) COMPANY ON MINING BUSINESS PERMIT OF TIMAH COMPANY in Bangka
Authors: Azizah Nur
Published: January 2024

This thesis was aimed to find out and analyze whether the issuance of a Certificate of Cultivation Rights on Mining Business Permit (IUP) complies with the secure principle that can guarantee legal certainty and the implications of issuance of Cultivation Right Certificate on an IUP for Cultivation Right and IUP holders. This research applied a normative legal research or library research method, which was carried out by examining library materials or secondary data. Based on the research results, the authors concluded that: First, the issuance of GPL Company in accordance with the provisions of the Laws and Regulations in the field of land, and also in accordance with the fact that IUP was not the ownership of land rights, so there were no land rights as referred to in Article 16 paragraph (1) Law Number 5 of 1960 concerning Agrarian Fundamentals Regulations (UUPA) which were born earlier on the land in question, as well as considering the agreement between TIMAH  Company as the holder of Mining Business Permit and GPL Company as the holder of land rights is included as part of the consideration in the decision on granting Cultivation Rights to GPL Company met the secure principle. Second, the legal implication of issuing a Cultivation Right Certificate above the IUP for GPL Company as a land rights holder and TIMAH Company as an IUP holder was that the Cultivation Right of GPL Company was the legitimacy of legal land rights and received legal protection so that they did not overlap with IUP.
Implementation Of Mining Management And Enterprise Policies Based On The Principles Of Social Justice And Community Welfare
Authors: Pelupessy Eddy -
Published: January 2024

This research aims to find out and understand the management and exploitation policies of mining natural resources, as well as to know and understand the application of the concept of community-based justice in the management of mining natural resources. Using a socio-cultural juridical approach, that law cannot be separated from people's lives. Data collection techniques were carried out by means of interviews, distributing questionnaires and observation. The results of the research reveal that constitutionally the management and exploitation of mines based on community justice has been carried out in three ways, namely regulation, management and supervision. Mining industry practices in Bogobaida District, Noumowodide Village, Paniai Regency, found illegal gold mining practices carried out by mining companies and the community around the mining area itself, they did not apply the principles of gold mining work that were good and beneficial for future generations. Therefore, to maximize legal protection and apply the concept of local community-based justice in a number of mining areas, the Paniai Regency Government has issued Paniai Regent Decree Number 14 of 2014 concerning the termination of Unlicensed Gold Mining Activities (PETI) in the Bogobaida District, Noumowodide Village. Regency/City Regional Governments must be proactive in mapping mineral potential in their areas and must pay attention to licensing provisions regulated by government policies in the mining, mineral and coal sectors.
Inclusive Social Marketing: Representation and Diversity in Brand Campaigns
Authors: Verbytska Anna , Lysenko Iryna , Babachenko Larysa , Kraskivska Nataliia
Published: January 2024

Over the past two decades, many marketing strategies have emerged around the world, as sales professionals have been searching for a universal language that millions of potential buyers can understand. Inclusive marketing has become a real breakthrough in this area, combining the social and consumer needs of the target audience in advertising campaigns. That is why today companies use inclusive marketing tools in order to attract the attention of various audiences and form a friendly target audience. The purpose of the study was to substantiate the peculiarities of inclusive marketing and to assess the possibilities of using the inclusion to create a positive image of a brand. In the course of the study, it was proved that, a necessary condition for modern companies’ development is the creation of a friendly and inclusive marketing campaign that would take into account the specifics of the entire target audience and allow them paying attention to each potential client. Inclusive marketing has been proven to present products, services, or applications in a context that evokes a deep emotional response from people and makes them feel noticed and understood. It can emphasise or address issues related to ethnic, gender, and socio-cultural differences. The goal of inclusive marketing is to understand and meet the needs of the target audience, attract potential buyers by increasing empathy, and solve life problems. At the same time, each member of the target audience should feel in the centre of attention and feel that their needs can be met, and their wishes can be taken into account, without focusing on their characteristics or disabilities.
The Impact of Digital Marketing on the Performance of Small and Medium–Sized Enterprises in North Macedonia
Authors: Veseli-Kurtishi Teuta
Published: January 2024

This research paper investigates the impact of digital marketing on the performance of Small and Medium-sized Enterprises (SMEs) in North Macedonia. Digital marketing has emerged as a powerful tool for businesses to reach their target audience, enhance brand awareness, and increase sales revenue. However, the extent to which SMEs in North Macedonia have embraced digital marketing and the specific impact it has on their performance remains underexplored. Through a comprehensive literature review and empirical analysis, this study aims to shed light on the relationship between digital marketing strategies and SME performance indicators. The research methodology involves collecting data from a diverse sample of SMEs, analyzing the influence of digital marketing on outcomes such as sales revenue, customer acquisition, brand awareness, and so on. The findings of this study reveal that SMEs in North Macedonia are increasingly utilizing digital marketing strategies, with social media marketing and email marketing being the most used channels. Moreover, digital marketing is found to have a significant positive impact on SME performance, particularly in terms of increasing sales revenue and enhancing customer engagement. Overall, this research paper underscores the importance of digital marketing as a strategic tool for SMEs and provides valuable insights into the relationship between digital marketing initiatives and SME performance. It offers a foundation for future research in this area and emphasizes the need for continuous adaptation and innovation in the ever-evolving digital landscape.
The acute effects of kinesio-taping on movement kinematics and muscle co-activation in rowing athletes
Authors: Wator Jennifer , Battis Aurora , Vellucci Chris , Beaudette Shawn M.
Published: January 2024

BACKGROUND: Rowing-related low back disorders may occur from inconsistent technique, high trunk flexion and training volumes, overactivation of paraspinal muscles, and fatigue. OBJECTIVE: To examine if kinesiology tape (KT) affixed to the trunk dorsum affects muscular co-activation and neuromuscular control to limit dangerous rowing movements and associated injuries. METHODS: Participants (n= 18) completed two 2000 m rowing trials under BASELINE and KT conditions. KT was applied to the skin superficial to the paraspinals bilaterally with 60% pre-strain. Participants were instructed to minimize any sensation of tension. Whole body kinematics were obtained using inertial measurement units (IMUs), and surface electromyograms (EMGs) were recorded from trunk and lower extremity. Changes in joint range-of-motion (ROM) and co-activation indices (CAIs) were analyzed for shoulder, lumbar, hip, and knee. RESULTS: Responding participants (n= 5) were identified by reduced maximum lumbar flexion during the KT condition. As expected, significant differences occurred in maximum and minimum lumbar flexion/extension between responders and non-responders to KT. Additionally, there was significant reduction in mean trunk muscle co-activation in both those who did and did not respond to KT through reductions in maximum lumbar flexion. CONCLUSION: KT can be an effective at reducing mean trunk co-activation during a rowing trial in the flexed catch position. Variable responses suggest that further work is necessary to optimize the efficacy of sensory cues derived from KT during rowing movements.
EGFR, HLA-G, CD70, c-MET, and NY-ESO1 as potential biomarkers in high grade epithelial ovarian carcinoma
Authors: Vo Duc , Liu Yan , Sood Anil K. , Rezvani Katy , Jazaeri Amir A. , Liu Jinsong
Published: January 2024

High grade epithelial ovarian carcinoma is an aggressive tumor. Treatment includes platinum therapy, however it recurs in most patients due to therapy resistance. In this project, we study the immunohistochemical (IHC) expression of five potential biomarkers/prognostic markers in high grade epithelial ovarian carcinoma: EGFR, HLA-G, CD70, c-MET, and NY-ESO1. A cohort of 274 patients is used. We compare the IHC expression with age, stage, ascites status, family history of cancer, disease free survival (DFS) and overall survival (OS). EGFR expression is significantly correlated with family history and worse OS. HLA-G is associated with worse OS. To confirm the results of EGFR and HLA-G, a second separated cohort of 248 patients is used. Positive EGFR expression again shows worse OS, while HLA-G expression has worse prognostic trend. CD70 has a worse OS trend. C-MET and NY-ESO1 do not have any clinical correlations. EGFR can potentially serve as target in future clinical immune therapy trials.
GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis
Authors: Dang Tianfeng , Yu Jieqing , Yu Yanqing , Jiang Junjie , Shi Yang , Yu Simin , Peng Congli , Min Xiang , Xiong Yuanping , Long Ping , Zhou Wensheng , Dai Daofeng
Published: January 2024

GPX4 has attracted much attention as a key molecule of cell ferroptosis, but its role in cell apoptosis is rarely reported, and its role in apoptosis of thyroid cancer (TC) cell has not been reported. The analysis of TCGA database showed that both GPX4 and FKBP8 were highly expressed in TC tumor tissues; The expression of GPX4 and FKBP8 were positively correlated. The immunohistochemical analysis further confirmed that GPX4 and FKBP8 were highly expressed in TC tumor tissues. In addition, the high expression of GPX4 and FKBP8 were both significantly correlated with the poor prognosis of TC. Silencing GPX4 significantly inhibited the proliferation, induced apoptosis of TC cells, and reduced tumor growth in mice. The co-immunoprecipitation assay revealed a physical interaction between GPX4 and FKBP8 observed in the TC cells. Knockdown of FKBP8 significantly inhibited the proliferation and induced apoptosis of TC cells. Rescue experiments suggested that knockdown of FKBP8 could reverse the strengthens of cell proliferation and apoptosis and the higher expression of FKBP8 and Bcl-2 caused by overexpression of GPX4. Our results suggest that the GPX4/FKBP8/Bcl-2 axis promotes TC development by inhibiting TC cell apoptosis, which provides potential molecular targets for TC therapeutic strategies.
Involvement of FAM170B-AS1, hsa-miR-1202, and hsa-miR-146a-5p in breast cancer
Authors: Abd ELhafeez Ahmed Saeed , Ghanem Hala Mostafa , Swellam Menha , Taha AlShaimaa Mohamed
Published: January 2024

BACKGROUND:

FAM170B-AS1 is usually expressed low in all organs except for testicular tissues. No study was performed to explore its role in breast cancer (BC). Contradictory results were reported about hsa-miR-1202 and hsa-miR-146a-5p in BC.

OBJECTIVE:

The present study aimed to explore the involvement of FAM170B-AS1 in BC using bioinformatics predictive tools, followed by a practical validation besides exploring the impact of hsa-miR-1202 and hsa-miR-146a-5p in BC.

METHODS:

This study enrolled 96 female patients with BC, 30 patients with benign breast diseases (BBD), and 25 control subjects. The expressions of circulating FAM170B-AS1, hsa-miR-1202, and hsa-miR-146a-5p were quantified using qRT-PCR. These ncRNAs’ associations, predictive, and diagnostic roles in BC were statistically tested. The underlying miRNA/mRNA targets of FAM170B-AS1 in BC were bioinformatically predicted followed by confirmation based on the GEPIA and TCGA databases.

RESULTS:

The expression of FAM170B-AS1 was upregulated in sera of BC patients and hsa-miR-1202 was upregulated in sera of BBD and BC patients while that of hsa-miR-146a-5p was downregulated in BC. These FAM170B-AS1 was significantly associated with BC when compared to BBD. FAM170B-AS1 and hsa-miR-1202 were statistically associated with the BC’s stage, grade, and LN metastasis. FAM170B-AS1 and hsa-miR-146a-5p gave the highest specificity and sensitivity for BC. KRAS and EGFR were predicted to be targeted by FAM170B-AS1 through interaction with hsa-miR-143-3p and hsa-miR-7-5p, respectively. Based on the TCGA database, cancer patients having mutations in FAM170B show good overall survival.

CONCLUSIONS:

The present study reported that for the first time, FAM170B-AS1 may be a potential risk factor, predictive, and diagnostic marker for BC. In addition, FAM170B-AS1 might be involved in BC by interacting with hsa-miR-143-3p/KRAS and hsa-miR-7-5p/EGFR through enhancement or repression that may present a new therapeutic option for BC.
Knowledge graph embedding in a uniform space
Authors: Tong Da , Chen Shudong , Ma Rong , Qi Donglin , Yu Yong
Published: January 2024

Knowledge graph embedding (KGE) is typically used for link prediction to automatically predict missing links in knowledge graphs. Current KGE models are mainly based on complicated mathematical associations, which are highly expressive but ignore the uniformity behind the classical bilinear translational model TransE, a model that embeds all entities of knowledge graphs in a uniform space, enabling accurate embeddings. This study analyses the uniformity of TransE and proposes a novel KGE model called ConvUs that follows uniformity with expressiveness. Based on the convolution neural network (CNN), ConvUs proposes constraints on convolution filter values and employs a multi-layer, multi-scale CNN architecture with a non-parametric L2 norm-based scoring function for the calculation of triple scores. This addresses potential uniformity-related issues in existing CNN-based KGE models, allowing ConvUs to maintain a uniform embedding space while benefiting from the powerful expressiveness of CNNs. Furthermore, circular convolution is applied to alleviate the potential orderliness contradictions, making ConvUs more suitable for conducting uniform space KGE. Our model outperformed the base model ConvKB and several baselines on the link prediction benchmark WN18RR and FB15k-237, demonstrating strong applicability and generalization and indicating that the uniformity of embedding space with high expressiveness enables more efficient knowledge graph embeddings.
Dementia detection using parameter optimization for multimodal datasets
Authors: Gupta Swati , Parikh Jolly , Jain Rachna , Kashi Namit , Khurana Piyush , Mehta Janya , Hemanth Jude
Published: January 2024

Dementia, a neurodegenerative disorder, is more prominent among elderly people. This disease is one of the primary contributors amongst other diseases having a high social impact in continents of Europe and America. Treatment of the neurological disorders of dementia patients have become possible due to the Advances in medical diagnosis as in the use of Magnetic Resonance Imaging (MRI). Artificial Intelligence (AI) and Machine Learning (ML) techniques have provided solutions that enable fast, accurate and autonomous detection of diseases at their early stage. This in turn has improvised the entire health care system. This study proposes a diagnostic method, based on ML, for detecting dementia disease. The Open Access Series of Imaging Studies (OASIS) database and Alzheimer’s dataset (4 class of images) have been used for testing and training of various ML models. This involves the classification of the dependent variable into demented and non-demented patient. ML models as in Support Vector Machine (SVM), Logistic Regression, Naïve Bayes, k-nearest neighbor (KNN), Random Forest, Adaptive Boosting (ADA boost), Gradient Boosting, XG Boost, were trained and tested using OASIS dataset. Models were trained with 70% of data and tested on 30% of data. Hyper tuning of parameters of these models was also carried out to check for improvement in the results. Analysis showed that Naïve Bayes was the best amongst all giving 95% accuracy, 98% precision, 93% recall and 95% F1-score.
Hypertension, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (SOL-INCA)
Authors: Márquez Freddie , Tarraf Wassim , Stickel Ariana M. , González Kevin A. , Testai Fernando D. , Cai Jianwen , Gallo Linda C. , Talavera Gregory A. , Daviglus Martha L. , Wassertheil-Smoller Sylvia , DeCarli Charles , Schneiderman Neil , González Hector M.
Published: January 2024

Background: Hypertension can have deleterious effects on cognitive function; however, few studies have examined its effects on cognition among Hispanics/Latinos. Objective: To assess associations between hypertension status with 1) change in cognitive performance, and 2) having mild cognitive impairment (MCI) among diverse Hispanics/Latinos. Methods: This population-based, prospective cohort, multisite study included Hispanic/Latino adults aged 45 to 72 years in enrolled in the Hispanic Community Health Study/Study of Latinos at Visit 1 (2008–2011; mean age of 63.40±8.24 years), and the Study of Latinos-Investigation of Neurocognitive Aging at Visit 2 (2016–2018), with a mean follow-up duration of 7 years (n = 6,173). Hypertension status was assessed at both visits: normotension (no hypertension), incident hypertension (only at Visit 2), and persistent hypertension (at both visits). We examined change in cognitive performance and having MCI (only assessed at Visit 2) relative to hypertension status and adjusted for demographics and cardiovascular disease risk factors. Results: Compared to normotension, persistent hypertension was associated with significantly increased decline in verbal fluency (β= –0.08; CI = [–0.16;–0.01]; p < 0.05), and processing speed (β= –0.11; CI = [–0.20;–0.02]; p < 0.05). Incident hypertension was not associated with significant change in cognitive performance. Both incident (OR = 1.70; CI = [1.16;2.50]; p < 0.01) and persistent hypertension (OR = 2.13; CI = [1.57;2.88]; p < 0.001) were associated with significantly higher odds ratios of having MCI. Conclusions: These findings indicate that persistent hypertension is associated with clinical impairment and domain-specific cognitive decline in middle-aged and older Hispanics/Latinos. It underscores the importance of monitoring blood pressure in routine healthcare visits beginning at midlife in this population to reduce the burden of cognitive decline.
Blood-Based mtDNA Quantification Indicates Population-Specific Differences Associated with Alzheimer’s Disease-Related Risk
Authors: Gorham Isabelle K. , Reid Danielle Marie , Sun Jie , Zhou Zhengyang , Barber Robert C. , Phillips Nicole R.
Published: January 2024

Background: Age is known to be the biggest risk factor for Alzheimer’s disease (AD), and Mexican Americans (MAs), who are one of the fastest-aging populations in the United States, are at a uniquely elevated risk. Mitochondrial stress and dysfunction are key players in the progression of AD and are also known to be impacted by lifestyle and environmental exposures/stressors. Objective: This study aimed to identify population-specific differences in indicators of mitochondrial stress and dysfunction associated with AD risk that are detectable in the blood. Methods: Examining blood from both non-Hispanic white (NHW) and MA participants (N = 527, MA n = 284, NHW n = 243), mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) copy numbers were assessed through quantitative PCR. Data was stratified by population and sample type, and multiple linear regression analyses were performed to identify factors that may influence this phenotype of mitochondrial dysfunction. Results: In the MA cohort, there was a significant relationship between cellular mtDNA:nDNA ratio and body mass index, CDR sum of boxes score, the APOE ɛ2/ɛ3 genotype, and education. Further, there was a significant relationship between cell-free mtDNA copy number and both education and CDR sum score. In the NHW cohort, there was a significant relationship between cellular mtDNA:nDNA ratio and both age and CDR sum score. Age was associated with cell-free mtDNA in the NHW cohort. Conclusions: This evidence supports the existence of population-based differences in the factors that are predictive of this blood-based phenotype of mitochondrial dysfunction, which may be indicative of cognitive decline and AD risk.
The Role of Diet in Parkinson’s Disease
Authors: Tosefsky Kira N. , Zhu Julie , Wang Yolanda N. , Lam Joyce S.T. , Cammalleri Amanda , Appel-Cresswell Silke
Published: January 2024

The aim of this review is to examine the intersection of Parkinson’s disease (PD) with nutrition, to identify best nutritional practices based on current evidence, and to identify gaps in the evidence and suggest future directions. Epidemiological work has linked various dietary patterns and food groups to changes in PD risk; however, fewer studies have evaluated the role of various diets, dietary components, and supplements in the management of established PD. There is substantial interest in exploring the role of diet-related interventions in both symptomatic management and potential disease modification. In this paper, we evaluate the utility of several dietary patterns, including the Mediterranean (MeDi), Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), Alternative Healthy Eating Index (AHEI), vegan/vegetarian, and ketogenic diet in persons with PD. Additionally, we provide an overview of the evidence relating several individual food groups and nutritional supplements to PD risk, symptoms and progression.
Characterization of Novel Human β-glucocerebrosidase Antibodies for Parkinson’s Disease Research
Authors: Jong Tiffany , Gehrlein Alexandra , Sidransky Ellen , Jagasia Ravi , Chen Yu
Published: January 2024

Background:

Mutations in GBA1, which encodes the lysosome enzyme β-glucocerebrosidase (also referred to as acid β-glucosidase or GCase), are the most common genetic risk factor for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Evidence also suggests that loss of GCase activity is implicated in PD without GBA1 mutations. Consequently, therapies targeting GCase are actively being pursued as potential strategies to modify the progression of PD and related synucleinopathies. Despite this significant interest in GCase as a therapeutic target, the lack of well-characterized GCase antibodies continues to impede progress in the development of GCase-targeted therapies.

Objective:

This study aims to independently evaluate human GCase (hGCase) antibodies to provide recommendations for western blot, immunofluorescence, immunoprecipitation, and AlphaLISA (Amplified Luminescent Proximity Homogeneous Assay) assays.

Methods:

Two mouse monoclonal antibodies, hGCase-1/17 and hGCase-1/23, were raised against hGCase using imiglucerase, the recombinant enzyme developed to treat patients, as the antigen. These novel antibodies, alongside commonly used antibodies in the field, underwent evaluation in a variety of assays.

Results:

The characterization of hGCase-1/17 and hGCase-1/23 using genetic models including GBA1 loss-of-function human neuroglioma H4 line and neurons differentiated from human embryonic stem cells revealed their remarkable specificity and potency in immunofluorescence and immunoprecipitation assays. Furthermore, a hGCase AlphaLISA assay with excellent sensitivity, a broad dynamic range, and suitability for high throughput applications was developed using hGCase-1/17 and hGCase-1/23, which enabled a sandwich assay configuration.

Conclusions:

The hGCase immunofluorescence, immunoprecipitation, and AlphaLISA assays utilizing hGCase-1/17 and hGCase-1/23 will not only facilitate improved investigations of hGCase biology, but can also serve as tools to assess the distribution and effectiveness of GCase-targeted therapies for PD and related synucleinopathies.
Another Step Forward for Freezing of Gait in Parkinson’s Disease
Authors: Fomenko Anton , Fasano Alfonso , Kalia Suneil K.
Published: January 2024

The study “A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease” by Milekovic et al. introduces a novel neuroprosthesis for treating locomotor deficits in late-stage Parkinson’s disease (PD). This approach employs an epidural spinal array targeting dorsal roots and electromyography to create a spatiotemporal map of muscle activation, aiming to restore natural gait patterns. Significant improvements in gait freezing and balance were observed in both non-human primate models and a human patient, resulting in improved mobility and quality of life. This innovative method, integrating real-time feedback and non-invasive motor intention decoding, marks a significant advancement in PD treatment.
The effects of gestational age on neonatal cholestasis: A retrospective cohort study
Authors: El Raichani N. , Thibault M. , Alvarez F. , Lavoie J.-C. , Mohamed I.
Published: January 2024

BACKGROUND: Reference guidelines for neonatal conjugated hyperbilirubinemia (cholestasis) management use a uniform approach regardless of gestational age (GA). We hypothesize that the clinical pattern of neonatal cholestasis is tightly related to GA. The aim of this study was to describe the effects of GA on neonatal cholestasis. METHODS: A retrospective 4-year cohort study in a 70-bed neonatal care unit. Neonates with conjugated bilirubin≥34.2μmol/L (2 mg/dL) were identified. The incidence, clinical characteristics, etiology, treatment, and prognosis were compared between infants <32 and≥32 weeks GA. RESULTS: Overall incidence of cholestasis was 4% (125/3402). It was >5 times higher and the mean duration was >1.5 times longer in neonates <32 weeks GA (10% versus 1.8%, p <0.01 and 49 versus 31 days, p <0.01, respectively). The onset of cholestasis was later in neonates <32 weeks (22 versus 10 days of life, p <0.001). This later onset of cholestasis was associated with parenteral nutrition, whereas the earlier onset was associated with other causes. Treatment using fish oil lipids was more frequently administrated to infants <32 weeks GA, whereas Ursodeoxycholic acid was administrated more frequently in≥32 weeks GA. Cholestasis resolved during hospitalization in 73% of <32 versus 38% in≥32 weeks GA infants (p <0.01). CONCLUSIONS: The incidence, clinical presentation, etiology, treatment, and clinical evolution of neonatal cholestasis were all significantly affected by GA. Our results support the use of a GA-oriented approach for the management of neonatal cholestasis.
Open data dissemination at Eurostat: State of the art
Authors: Laaboudi Christine , Karlberg Martin , Islam Maja
Published: January 2024

Eurostat is charged with providing high-quality statistics for Europe, and the current information landscape is making it increasingly challenging to do so. This paper presents the Eurostat dissemination approach (including the traditional dissemination vectors), and thereafter proceeds to present the recent initiatives to make European statistics data and metadata available in the form of Linked Open Data (LOD). After presenting some of the main challenges for open data dissemination (complete reproducibility, availability of high-quality LOD, capacity to consume LOD and achieving meaningful mashups between official statistics LOD and other data sources), it concludes by noting the potential of LOD to foster transparency, reproducibility, collaboration, interdisciplinary research driving scientific advancements, and contributing to a broader understanding of complex scientific challenges.