bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Chitosan Nanoemulsion on Enhancing the Phytochemical Contents, Health-Promoting Components, and Shelf Life of Raspberry (Rubus sanctus Schreber)
Authors: Ishkeh Shirin Rahmanzadeh , Shirzad Habib , Asghari Mohammadreza , Alirezalu Abolfazl , Pateiro Mirian , Lorenzo José M.
Published: March 2021

Due to high water content and perishability, the raspberry fruit is sensitive to postharvest fungal contamination and postharvest losses. In this study, chitosan was used as an edible coating to increase the storage of raspberries, and nanotechnology was used to increase chitosan efficiency. The fruit was treated with an emulsion containing nanoparticles of chitosan (ECNPC) at 0, 2.5, and 5 g L−1, and stored for 9 d. Decay extension rate, fruit phytochemical contents, including total phenolics, flavonoids, and anthocyanin content, phenylalanine ammonia-lyase (PAL), and guaiacol-peroxidase enzymes and antioxidant activity, and other qualitative properties were evaluated during and at the end of storage. After 9 d of storage, the highest amounts of phenolics compounds, PAL enzyme activity, and antioxidant activity were observed in fruit treated with ECNPC at 5 g L−1. The highest levels of total phenol, PAL enzyme activity, and antioxidant activity were 57.53 g L−1, 118.88 μmol/min trans-cinnamic acid, and 85.16%, respectively. ECNPC can be considered as an effective, safe, and environmentally friendly method for enhancing fruit phytochemical contents, postharvest life, and health-promoting capacity.
Improving the Dispersion Behavior of Organic Components in Water-Based Electrode Dispersions for Inkjet Printing Processes
Authors: Kolb Cara G. , Lehmann Maja , Lindemann Jana-Lorena , Bachmann Andreas , Zaeh Michael F.
Published: March 2021

Water-based processing of electrodes is associated with an enhanced environmental footprint for lithium-ion battery (LIB) production in conjunction with reduced costs. This trend is accompanied by an increasing demand for electrode dispersion processing in inkjet printing. However, most of the dispersion components show a low inherent dispersibility with poor stability in aqueous formulations. This is particularly important when it comes to qualifying electrode dispersions for use in inkjet printing, since the effect of agglomeration and sedimentation effects must be effectively prevented. Therefore, additives are needed to improve the dispersive behavior. This paper analyzes the suitability of dispersants for organic electrode components, in particular graphite and carbon black. An empirical approach was devised on the basis of comprehensive theoretical considerations. Empirical investigations revealed that the utilization of polyvinylpyrrolidone (PVP) favored the enhanced stabilization of graphite nanoparticles. The addition of Triton X-100 (TX-100) resulted in an improved stabilization of carbon black. Based on these empirical studies, a methodology was derived, which supports the application of suitable dispersants in printable dispersions.
LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells
Authors: Flores-Huerta Nadia , Silva-Cázares Macrina B. , Arriaga-Pizano Lourdes A. , Prieto-Chávez Jessica L. , López-Camarillo César
Published: March 2021

Breast cancer is an aggressive disease with a high incidence in women worldwide. Two decades ago, a controversial hypothesis was proposed that cancer arises from a subpopulation of “tumor initiating cells” or “cancer stem cells-like” (CSC). Today, CSC are defined as small subset of somatic cancer cells within a tumor with self-renewal properties driven by the aberrant expression of genes involved in the maintenance of a stemness-like phenotype. The understanding of the underlying cellular and molecular mechanisms involved in the maintenance of CSC subpopulation are fundamental in the development and persistence of breast cancer. Nowadays, the hypothesis suggests that genetic and epigenetic alterations give rise to breast cancer stem cells (bCSC), which are responsible for self-renewal, tumor growth, chemoresistance, poor prognosis and low survival in patients. However, the prominence of bCSC, as well as the molecular mechanisms that regulates and promotes the malignant phenotypes, are still poorly understood. The role of non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as oncogenes or tumor suppressor genes has been recently highlighted by a plethora of studies in breast cancer. These ncRNAs positively or negatively impact on different signaling pathways that govern the cancer hallmarks associated with bCSC, making them attractive targets for therapy. In this review, we present a current summary of the studies on the pivotal roles of lncRNAs and microRNAs in the regulation of genes associated to stemness of bCSC.
Cellular and Molecular Mechanisms Underlying Glioblastoma and Zebrafish Models for the Discovery of New Treatments
Authors: Reimunde Pedro , Pensado-López Alba , Carreira Crende Martín , Lombao Iglesias Vanesa , Sánchez Laura , Torrecilla-Parra Marta , Ramírez Cristina M. , Anfray Clément , Torres Andón Fernando
Published: March 2021

Glioblastoma (GBM) is the most common of all brain malignant tumors; it displays a median survival of 14.6 months with current complete standard treatment. High heterogeneity, aggressive and invasive behavior, the impossibility of completing tumor resection, limitations for drug administration and therapeutic resistance to current treatments are the main problems presented by this pathology. In recent years, our knowledge of GBM physiopathology has advanced significantly, generating relevant information on the cellular heterogeneity of GBM tumors, including cancer and immune cells such as macrophages/microglia, genetic, epigenetic and metabolic alterations, comprising changes in miRNA expression. In this scenario, the zebrafish has arisen as a promising animal model to progress further due to its unique characteristics, such as transparency, ease of genetic manipulation, ethical and economic advantages and also conservation of the major brain regions and blood–brain–barrier (BBB) which are similar to a human structure. A few papers described in this review, using genetic and xenotransplantation zebrafish models have been used to study GBM as well as to test the anti-tumoral efficacy of new drugs, their ability to interact with target cells, modulate the tumor microenvironment, cross the BBB and/or their toxicity. Prospective studies following these lines of research may lead to a better diagnosis, prognosis and treatment of patients with GBM.
Interobserver Reliability of the Endoscopic Ultrasound Criteria for the Diagnosis of Early Chronic Pancreatitis: Comparison between the 2009 and 2019 Japanese Diagnostic Criteria
Authors: Yamamiya Akira , Irisawa Atsushi , Tominaga Keiichi , Tsuchida Kohei , Sugaya Takeshi , Tsunemi Misako , Hoshi Koki , Jinnai Hidehito , Yamabe Akane , Izawa Naoya , Iwasaki Mari , Takimoto Yoichi , Kanamori Akira , Nagashima Kazunori , Minaguchi Takahito , Kashima Ken , Kunogi Yasuhito , Sato Ai , Goda Kenichi , Iijima Makoto , Haruyama Yasuo
Published: March 2021

In 2009, diagnostic criteria for early chronic pancreatitis (DCECP2009) were proposed by the Japan Pancreas Society. This study aimed to evaluate the interobserver reliability (IOR) of endoscopic ultrasound (EUS) criteria for diagnosis of early chronic pancreatitis (ECP) between DCECP2009 and 2019 diagnostic criteria for ECP (DCECP2019) to assess the validity of the revision from the perspective of EUS findings. Among patients who underwent a detailed observation of the pancreas by EUS at our institution between January 2018 and March 2019, EUS images of 97 patients were extracted. Images were reviewed by 12 gastrointestinal endoscopy experts (eight pancreatologists, group A and four nonpancreatologists, group B). The overall kappa (K)-values for the IOR of the DCECP2009 EUS criteria were 0.424 and 0.563:0.231 for groups A:B, whereas the overall K-values for the DCECP2019 criteria were 0.618, and 0.733:0.442 for groups A:B. Regarding changes in the final diagnosis of ECP based on clinical features and EUS findings, 20 cases were definite ECP, 53 were probable ECP, and 24 were normal according to DCECP2009. In contrast, seven were definite ECP, 19 were probable ECP, and 71 were normal according to DECEP2019. IOR of DCECP2019 was higher than that of DCECP2009, which indicates an improvement in precision.
Cyclist Effort Features: A Novel Technique for Image Texture Characterization Applied to Larynx Cancer Classification in Contact Endoscopy—Narrow Band Imaging
Authors: Esmaeili Nazila , Boese Axel , Davaris Nikolaos , Arens Christoph , Navab Nassir , Friebe Michael , Illanes Alfredo
Published: March 2021

Background: Feature extraction is an essential part of a Computer-Aided Diagnosis (CAD) system. It is usually preceded by a pre-processing step and followed by image classification. Usually, a large number of features is needed to end up with the desired classification results. In this work, we propose a novel approach for texture feature extraction. This method was tested on larynx Contact Endoscopy (CE)—Narrow Band Imaging (NBI) image classification to provide more objective information for otolaryngologists regarding the stage of the laryngeal cancer. Methods: The main idea of the proposed methods is to represent an image as a hilly surface, where different paths can be identified between a starting and an ending point. Each of these paths can be thought of as a Tour de France stage profile where a cyclist needs to perform a specific effort to arrive at the finish line. Several paths can be generated in an image where different cyclists produce an average cyclist effort representing important textural characteristics of the image. Energy and power as two Cyclist Effort Features (CyEfF) were extracted using this concept. The performance of the proposed features was evaluated for the classification of 2701 CE-NBI images into benign and malignant lesions using four supervised classifiers and subsequently compared with the performance of 24 Geometrical Features (GF) and 13 Entropy Features (EF). Results: The CyEfF features showed maximum classification accuracy of 0.882 and improved the GF classification accuracy by 3 to 12 percent. Moreover, CyEfF features were ranked as the top 10 features along with some features from GF set in two feature ranking methods. Conclusion: The results prove that CyEfF with only two features can describe the textural characterization of CE-NBI images and can be part of the CAD system in combination with GF for laryngeal cancer diagnosis.
Full-Duplex MAC Protocol Based on CSMA/CA for Switching Transmission Mode
Authors: Kim Jin-Ki , Lee Won-Jae , Kim Jae-Hyun
Published: March 2021

Full-duplex (FD) radios can transmit and receive packets simultaneously in the same frequency band. Although this potentially doubles the spectral efficiency, it also causes inter-node interference, which was not an issue for half-duplex (HD) radios and can significantly reduce FD radio throughput. This paper proposes a hybrid transmission switching algorithm to reduce performance degradation due to inter-node interference. In contrast to previous studies that only considered channel capacity, we determine the transmission mode by considering the modulation and coding scheme (MCS). The access point compares the required transmission time for HD, FD, and hybrid mode and selects the mode with the best network throughput. We also designed an analytical model to evaluate network throughput for the proposed algorithm. In particular, we consider FD pair probability, which has not been addressed previously. Analytical and simulation results verify that the proposed algorithm improves network performance.
Congruent Genetic and Demographic Dispersal Rates in a Natural Metapopulation at Equilibrium
Authors: Legrand Delphine , Baguette Michel , Prunier Jérôme G. , Dubois Quentin , Turlure Camille , Schtickzelle Nicolas
Published: March 2021

Understanding the functioning of natural metapopulations at relevant spatial and temporal scales is necessary to accurately feed both theoretical eco-evolutionary models and conservation plans. One key metric to describe the dynamics of metapopulations is dispersal rate. It can be estimated with either direct field estimates of individual movements or with indirect molecular methods, but the two approaches do not necessarily match. We present a field study in a large natural metapopulation of the butterfly Boloria eunomia in Belgium surveyed over three generations using synchronized demographic and genetic datasets with the aim to characterize its genetic structure, its dispersal dynamics, and its demographic stability. By comparing the census and effective population sizes, and the estimates of dispersal rates, we found evidence of stability at several levels: constant inter-generational ranking of population sizes without drastic historical changes, stable genetic structure and geographically-influenced dispersal movements. Interestingly, contemporary dispersal estimates matched between direct field and indirect genetic assessments. We discuss the eco-evolutionary mechanisms that could explain the described stability of the metapopulation, and suggest that destabilizing agents like inter-generational fluctuations in population sizes could be controlled by a long adaptive history of the species to its dynamic local environment. We finally propose methodological avenues to further improve the match between demographic and genetic estimates of dispersal.
The Spatiotemporal Evolution Analysis of Ecosystem Pattern in Wenchuan (Magnitude 8.0) Earthquake Disaster Area, China
Authors: Zhang Bing , Hou Peng , Xu Hai-tao , Zhao Yan-hong , Bai Jun-jun , Liu Xian-lin
Published: March 2021

The ecological system is the basis of human survival and global environmental protection. In the process of development, countries will pay close attention to the changing state of the ecosystem. Taking the ecosystem pattern as the research object, a three-layer analysis method was proposed. The transfer matrix and landscape index were used as the first layer to analyze the basic changes. Grey correlation, range-coupling coordination and relative priority were used as the second layer to analyze the reasons of the change. The interval-entropy weight, TOPSIS (Technique for Order Preference by Similarity to an Ideal Solution), was used as the third layer to evaluate the quality of the change. The ten counties in the worst-hit areas of the Wenchuan earthquake were analyzed from different angles, with county region, intensity zone and ecosystem as the objects, and the following results were obtained: (1) Taking Mianzhu City as an example, from 2000 to 2010 and 2018, the conversion ratio of forest, grassland and farmland is 54.24, 59.19, 17.21, 20.06, 37.39 and 52.86%, which were distributed in the north, central and southern parts, respectively. (2) Taking the ninth intensity zone as an example, the forest landscape fragmentation increased, disturbance decreased, and species diversity increased. There is a high influence and restriction relationship between ecosystem and landscape pattern in the total landscape area change. Additionally, the relationship between them tends to develop in a benign way. As of 2018, it is in the change state of moderate imbalance-ecosystem lag. (3) Taking the county ecosystem change as an example, urban type is the best in the counties of ecosystem change, of which Shifang is the best and Pingwu is the worst. The results show that this method can effectively compare and analyze the changes in the multi-regional ecosystem pattern, which has the characteristics of universality and can also be applied to the research of ecosystem pattern change in special regions.
Family Meals, Conviviality, and the Mediterranean Diet among Families with Adolescents
Authors: de la Torre-Moral Andrea , Fàbregues Sergi , Bach-Faig Anna , Fornieles-Deu Albert , Medina F. Xavier , Aguilar-Martínez Alicia , Sánchez-Carracedo David
Published: March 2021

Two aspects that characterize the Mediterranean diet (MD) are “what” and “how” we eat. Conviviality relates to “how” we eat and to the pleasure of sharing meals with significant people. The most studied concept is “family meals”, which includes conviviality, which involves “enjoying” family meals. Given the lack of research on convivial family meals in Mediterranean countries, the purpose of this qualitative study was to analyze the family meal representations and practices of families with 12- to 16-year-old adolescents to assess whether they responded to a pattern of conviviality, and to examine their association with MD adherence. Twelve semi-structured interviews were conducted and food frequency and family meal questionnaires were administered. A food pattern analysis was carried out and digital photos of meals were analyzed to examine eating habits and meal composition, respectively. The findings showed that parents believed family meals are a space for socialization and communication. Items relating to the conviviality of family meals identified in the study were meal frequency, meals at the table, lack of digital distractions, pleasant conversations, and time spent on family meals. Attention should be paid to conviviality in Mediterranean families when designing multi-approach strategies to promote healthy eating among adolescents.
Children and Parental Barriers to Active Commuting to School: A Comparison Study
Authors: Aranda-Balboa María Jesús , Chillón Palma , Saucedo-Araujo Romina Gisele , Molina-García Javier , Huertas-Delgado Francisco Javier
Published: March 2021

The main objectives of this study were: to compare the barriers to active commuting to and from school (ACS) between children and their parents separately for children and adolescents; and to analyze the association between ACS and the children’s and parents’ barriers. A total of 401 child–parent pairs, from Granada, Jaén, Toledo and Valencia, self-reported, separately, their mode of commuting to school and work, respectively, and the children’s barriers to ACS. T-tests and chi-square tests were used to analyze the differences by age for continuous and categorical variables, respectively. Binary logistic regressions were performed to study the association between ACS barriers of children and parents and ACS. Both children and adolescents perceived higher physical and motivational barriers and social support barriers towards ACS than their parents (all p < 0.05). Additionally, the parents perceived higher distance, traffic safety, convenience, built environment, crime-related safety and weather as barriers towards ACS, than their children (all p < 0.05). Moreover, a higher perception of barriers was related to lower ACS. The results of our study showed the necessity of attenuating the perceptions of children and their parents in order to increase ACS. This is relevant to develop interventions in the specific contexts of each barrier and involving both populations.
Radiological Evaluation of Stainless Steel Crowns Placed on Permanent Teeth in Patients Treated under General Anaesthesia
Authors: Munoz-Sanchez Marie-Laure , Linas Natacha , Decerle Nicolas , Collado Valérie , Faulks Denise , Nicolas Emmanuel , Hennequin Martine , Cousson Pierre-Yves
Published: March 2021

Evidence-based evaluations of dental treatment are needed to support the development of special care dentistry services. This retrospective study was designed to collect and analyse X-ray images of permanent teeth restored with stainless steel crowns (SSC) in patients treated under general anaesthesia. Between 2013 and 2019, 360 permanent molars were crowned with SSCs in 198 adult patients. One calibrated investigator used an original validated tool to evaluate four radiographic criteria for molars restored with SSCs: (i) marginal adaptation; (ii) interdental proximal contact; (iii) the presence of glass ionomer cement overflow; and (iv) the loss of alveolar bone. Overall, no defect or a minor defect was reported for the majority of SSCs for the criteria “Marginal adaptation” (62.5%, n = 320), “Proximal contact” (82.2%, n = 236) and “Cement overflow” (95.8%, n = 337). Alveolar bone resorption was reported in 8.3% of cases, n = 14, after a mean period of 8.9 ± 14.3 months. It was shown that the restoration of permanent teeth using SSCs placed under general anaesthesia presents a low risk of periodontal morbidity in the medium term when assessed radiographically.
The Effect of Progressive Dynamic Balance Training on Physical Function, The Ability to Balance and Quality of Life Among Elderly Women Who Underwent a Total Knee Arthroplasty: A Double-Blind Randomized Control Trial
Authors: Lee Heon-Gyu , An Jungae , Lee Byoung-Hee
Published: March 2021

Total knee arthroplasty (TKA) is used to treat end-stage osteoarthritis. However, this surgical procedure affects the mechanical receptor function and impairs the ability to balance. Dynamic balance training has been reported to improve stability and self-confidence and safely yield increased physical activity. This study aimed to investigate the effect of dynamic balance training on physical function, the ability to balance and quality of life among patients who underwent TKA. Thirty-eight participants were assigned to either the progressive dynamic balance training (PDBT) with physical therapy group (n = 19) or the control group (n = 19). The experimental group undertook a dynamic balance program with physical therapy for 30 minutes per day, five times per week for six weeks, while the control group undertook physical therapy only. A continuous passive motion exercise was performed for 20 minutes after training by both groups. The outcomes were evaluated using the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index, pain pressure threshold (PPT), range of motion (ROM), Knee Outcome Survey-Activities of Daily Living (KOS-ADLS), Multifunction Force Measuring Plate, timed up and go (TUG) test and Short-Form Health Survey 36 (SF-36). Physical function (WOMAC Osteoarthritis Index, ROM and KOS-ADLS score) and the ability to balance (TUG test score, confidence ellipse area, path length and average velocity) significantly improved (p < 0.05) in the experimental group compared with the control group. In contrast, the physical component summary score for the SF-36 regarding quality of life significantly improved (p < 0.05); however, the mental component summary score for the SF-36 and PPT did not significantly differ between the groups. Therefore, we suggest that PDBT with physical therapy has positive effects on physical function, the ability to balance and quality of life among patients who underwent TKA.
Cancer Incidence and Mortality among Firefighters: An Overview of Epidemiologic Systematic Reviews
Authors: Laroche Elena , L’Espérance Sylvain
Published: March 2021

Firefighters are exposed to carcinogens that may increase their risk of developing many types of occupational cancer. Many systematic reviews (SRs) have been produced with sometimes conflicting conclusions. In this overview of reviews, we aim to assess the conclusion consistency across the available systematic reviews on the cancer risk in firefighters. Literature searches were conducted in several indexed databases and grey literature to retrieve systematic reviews aiming to evaluate cancer incidence or cancer mortality in firefighters. Results from included SRs were analyzed according to the tumour site. Out of 1054 records identified by the search in the databases, a total of 11 SRs were ultimately included. The original studies (n = 104) analyzed in the SRs were published between 1959 and 2018. The results consistently reported a significant increase in the incidence of rectal, prostate, bladder and testicular cancers as well as mesothelioma and malignant melanoma in firefighters compared to the general population. The SRs also indicate that death rates from rectal cancer and non-Hodgkin’s lymphoma are higher among firefighters. Consistent SR results suggest that several types of cancer may be more frequent in firefighters than in the general population.
Biomolecular Basis of Cellular Consciousness via Subcellular Nanobrains
Authors: Baluška František , Miller William B. , Reber Arthur S.
Published: March 2021

Cells emerged at the very beginning of life on Earth and, in fact, are coterminous with life. They are enclosed within an excitable plasma membrane, which defines the outside and inside domains via their specific biophysical properties. Unicellular organisms, such as diverse protists and algae, still live a cellular life. However, fungi, plants, and animals evolved a multicellular existence. Recently, we have developed the cellular basis of consciousness (CBC) model, which proposes that all biological awareness, sentience and consciousness are grounded in general cell biology. Here we discuss the biomolecular structures and processes that allow for and maintain this cellular consciousness from an evolutionary perspective.
Repositioning of Romanian Seaside Tourism as an Effect of Climate Change
Authors: Dumitrescu George-Cornel , Poladian Simona Moagar , Aluculesei Alina-Cerasela
Published: March 2021

The present paper examines the evolution of Romanian seaside tourism between 2008–2018 to find the connection between climate change and the number of total tourist arrivals. The vicious cycle of greenhouse gas emissions and climate change has become one of the most critical topics discussed due to its negative effect on the wellbeing of the planet and its impact on sustainable economic development in the long run. Various economic activities, including tourism, could be subject to dramatic changes due to global warming. Depending on the geographical location of tourist destinations, and the degree of fluctuation in climate indicators, there have been dramatic shifts in visitor flow. This situation has been aggravated as countries that were once famous for their summer season and seaside holidays are now affected by high temperatures. Such temperatures can hardly be tolerated by tourists, particularly those from the Nordic countries. By comparison, there are countries that have been known to have only two or three full summer months suitable for tourism at the seaside and which in the last years have had a more extended summer season. This situation could turn into a significant competitive regional economic advantage for countries such as Romania, at least in the short- and medium-term. In this context, we aim to investigate whether there are climatic conditions, such as the extension of the tourist season on the coast (in the case of destinations that have four seasons and are known for having a shorter number of summer days), that can be turned into advantages. In this regard, we have conducted exploratory research to analyse if there is a statistically significant correlation between the indicators regarding climate change and tourism arrivals on the Romanian seaside, namely Constanta county. For our study, we used secondary data, provided by the Romanian National Meteorological Administration and the National Institute of Statistics, and accumulated a detailed profile of Romanian seaside summer tourism in the context of actual climate changes and challenges. Climate change may have significant consequences on the tourism industry and economic growth as well. Information on the direct effects higher temperatures could have on tourism is lacking. Improving policy analysis is necessary to reduce uncertainties, further understanding, assess implications and enable the tourism industry to adapt to changing circumstances.
Analysis and Prediction of COVID-19 Using SIR, SEIQR, and Machine Learning Models: Australia, Italy, and UK Cases
Authors: Rahimi Iman , Gandomi Amir H. , Asteris Panagiotis G. , Chen Fang
Published: March 2021

The novel coronavirus disease, also known as COVID-19, is a disease outbreak that was first identified in Wuhan, a Central Chinese city. In this report, a short analysis focusing on Australia, Italy, and UK is conducted. The analysis includes confirmed and recovered cases and deaths, the growth rate in Australia compared with that in Italy and UK, and the trend of the disease in different Australian regions. Mathematical approaches based on susceptible, infected, and recovered (SIR) cases and susceptible, exposed, infected, quarantined, and recovered (SEIQR) cases models are proposed to predict epidemiology in the above-mentioned countries. Since the performance of the classic forms of SIR and SEIQR depends on parameter settings, some optimization algorithms, namely Broyden–Fletcher–Goldfarb–Shanno (BFGS), conjugate gradients (CG), limited memory bound constrained BFGS (L-BFGS-B), and Nelder–Mead, are proposed to optimize the parameters and the predictive capabilities of the SIR and SEIQR models. The results of the optimized SIR and SEIQR models were compared with those of two well-known machine learning algorithms, i.e., the Prophet algorithm and logistic function. The results demonstrate the different behaviors of these algorithms in different countries as well as the better performance of the improved SIR and SEIQR models. Moreover, the Prophet algorithm was found to provide better prediction performance than the logistic function, as well as better prediction performance for Italy and UK cases than for Australian cases. Therefore, it seems that the Prophet algorithm is suitable for data with an increasing trend in the context of a pandemic. Optimization of SIR and SEIQR model parameters yielded a significant improvement in the prediction accuracy of the models. Despite the availability of several algorithms for trend predictions in this pandemic, there is no single algorithm that would be optimal for all cases.
Residual Lung Function Impairment Is Associated with Hyperventilation in Patients Recovered from Hospitalised COVID-19: A Cross-Sectional Study
Authors: Crisafulli Ernesto , Gabbiani Daniele , Magnani Giulia , Dorelli Gianluigi , Busti Fabiana , Sartori Giulia , Senna Gianenrico , Girelli Domenico
Published: March 2021

Patients who have recovered from COVID-19 show persistent symptoms and lung function alterations with a restrictive ventilatory pattern. Few data are available evaluating an extended period of COVID-19 clinical progression. The RESPICOVID study has been designed to evaluate patients’ pulmonary damage previously hospitalised for interstitial pneumonia due to COVID-19. We focused on the arterial blood gas (ABG) analysis variables due to the initial observation that some patients had hypocapnia (arterial partial carbon dioxide pressure-PaCO2 ≤ 35 mmHg). Therefore, we aimed to characterise patients with hypocapnia compared to patients with normocapnia (PaCO2 > 35 mmHg). Data concerning demographic and anthropometric variables, clinical symptoms, hospitalisation, lung function and gas-analysis were collected. Our study comprised 81 patients, of whom 19 (24%) had hypocapnia as compared to the remaining (n = 62, 76%), and defined by lower levels of PaCO2, serum bicarbonate (HCO3−), carbon monoxide diffusion capacity (DLCO), and carbon monoxide transfer coefficient (KCO) with an increased level of pH and arterial partial oxygen pressure (PaO2). KCO was directly correlated with PaCO2 and inversely with pH. In our preliminary report, hypocapnia is associated with a residual lung function impairment in diffusing capacity. We focus on ABG analysis’s informativeness in the follow-up of post-COVID patients.
Balloon Pulmonary Angioplasty in Technically Operable and Technically Inoperable Chronic Thromboembolic Pulmonary Hypertension
Authors: Darocha Szymon , Araszkiewicz Aleksander , Kurzyna Marcin , Banaszkiewicz Marta , Jankiewicz Stanisław , Dobosiewicz Anna , Sławek-Szmyt Sylwia , Janus Magdalena , Grymuza Maciej , Pietrasik Arkadiusz , Mularek-Kubzdela Tatiana , Kędzierski Piotr , Pietura Radosław , Zieliński Dariusz , Biederman Andrzej , Lesiak Maciej , Torbicki Adam
Published: March 2021

Background: In this study, we aimed to assess the efficacy and safety of balloon pulmonary angioplasty (BPA) in patients with technically inoperable distal-type chronic thromboembolic pulmonary hypertension (d-CTEPH) and technically operable proximal-type disease (p-CTEPH) by analyzing the results of BPA treatment in two collaborating CTEPH referral centers. Methods and results: We assessed hemodynamic results, functional efficacy, complication and survival rate after BPA treatment in 70 CTEPH patients (median age 64 years; (interquartile range (IQR): 52–73 years)), of whom 16 (median age 73 years; (QR 62–82 years)) were in the p-CTEPH subgroup. Altogether, 377 BPA procedures were performed, resulting in significant (p < 0.001) improvement in mean pulmonary artery pressure (mPAP 48.6 ± 10 vs. 31.3 ± 8.6 mmHg), pulmonary vascular resistance (694 ± 296 vs. 333 ± 162 dynes*s*cm−5), six-minute walk test (365 ± 142 vs. 433 ± 120 metres) and N-terminal pro B-type natriuretic peptide (1307 (510–3294) vs. 206 (83–531) pg/mL). The rate of improvement did not differ between the sub-groups. Lung injury episodes and severe hemoptysis were similarly infrequent in d-CTEPH and p-CTEPH (6.4% vs. 5%; p = 0.55 and 1.0% vs. 2.5; p = 0.24, respectively). There was no significant difference between the sub-groups regarding survival (p = 0.53 by log-rank test). Conclusion: BPA may be beneficial in patients with p-CTEPH who cannot undergo pulmonary endarterectomy (PEA). Larger long-term studies are needed to better define the efficacy, safety, and optimal BPA procedural standards in this population.
Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review
Authors: Lambert Jo L. W. , De Schepper Sofie , Speeckaert Reinhart
Published: March 2021

The biologic era has greatly improved the treatment of Crohn’s disease and ulcerative colitis. Biologics can however induce a wide variety of skin eruptions, especially those targeting the TNF-α and Th17 pathway. These include infusion reactions, eczema, psoriasis, lupus, alopecia areata, vitiligo, lichenoid reactions, granulomatous disorders, vasculitis, skin cancer, and cutaneous infections. It is important to recognize these conditions as treatment-induced adverse reactions and adapt the treatment strategy accordingly. Some conditions can be treated topically while others require cessation or switch of the biological therapy. TNF-α antagonists have the highest rate adverse skin eruptions followed by ustekinumab and anti-integrin receptor blockers. In this review, we provide an overview of the most common skin eruptions which can be encountered in clinical practice when treating IBD (Inflammatory bowel disease) patients and propose a therapeutic approach for each condition.
Intraoperative Ultrasound Shear-Wave Elastography in Focal Cortical Dysplasia Surgery
Authors: Mathon Bertrand , Clemenceau Stéphane , Carpentier Alexandre
Published: March 2021

Previous studies reported interest in intraoperative shear-wave elastography (SWE) guidance for brain-tumor and epilepsy surgeries. Focal cortical dysplasia (FCD) surgery is one of the most appropriate indications for using SWE guidance. The aim of this study was to evaluate the efficacy of ultrasound SWE techniques for the intraoperative detection of FCDs. We retrospectively analyzed data from 18 adult patients with drug-resistant epilepsy associated with FCD who had undergone SWE-guided surgery. Conventional B-mode images detected FCD in 2 patients (11.1%), while SWE detected FCD in 14 patients (77.8%). The stiffness ratios between MRI-positive and -negative cases were significantly different (3.6 ± 0.4 vs. 2.2 ± 0.6, respectively; p < 0.001). FCDs were significantly more frequently detected by interoperative SWE in women (OR 4.7, 95% CI (1.7–12.7); p = 0.004) and in patients in whom FCD was visible on magnetic resonance imaging (MRI; OR 2.3, 95% CI (1.3–4.3); p = 0.04). At 1 year after surgery and at last follow-up (mean = 21 months), seizure outcome was good (International League Against Epilepsy (ILAE) Class 1 or 2) in 72.2% and 55.6% of patients, respectively. Despite some limitations, our study highlighted the potential of SWE as an intraoperative tool to detect FCD. Future technical developments should allow for optimizing intraoperative surgical-cavity evaluation from the perspective of complete FCD resection. Interobserver reliability of SWE measurements should also be assessed by further studies.
Household Wealth: Low-Yielding and Poorly Structured?
Authors: Radke Marc Peter , Rupprecht Manuel
Published: March 2021

In this paper, we present a newly generated data set on real returns of households’ aggregated asset holdings, which adds additional and more sophisticated information to existing relevant datasets in the literature. To do this, we draw on various datasets from public and private sources and then transform and combine them in a consistent manner that allows for international comparative and intertemporal analyses. Based on this, we address two current debates on the development of household wealth in the euro area that have been triggered by the low-interest environment. The first debate refers to the development of real yields on household wealth from 2000 to 2018, whereas the second debate deals with the mean-variance efficiency of household portfolios. Contrary to widespread belief, we find that yields on total wealth, which were largely dominated by non-financial assets’ yields, were mostly positive, although they exhibit a declining trend. Moreover, on average, overall real yields were significantly lower after 2008. Referring to portfolio efficiency, we find that current portfolios seem to be comparatively close to mean-variance efficiency. If households were to optimize their portfolios despite limited room for improvement, holdings of equity and investment fund shares should be reduced, contradicting common recommendations of financial advisors.
Conflicting Maps: How Legal Perspectives Could Minimize Zoning Cancellation in Republic of Korea
Authors: Moon Jung-kyun , Yoo Seon-bong , Sohn Hong-gyoo , Cho Yonng-sun
Published: March 2021

The purpose of this paper is to propose legal and policy enhancements that may prevent the cancellation of the legal force of zoning due to discord with the Korean Land Use Regulation Map (LURM) and secure legal stability. The legal force of zoning has been canceled because of the discordance of the LURM with past cadastral maps, and this has led to confusion regarding zoning decisions and even the postponement and cancellation of public projects. Here, the causes of LURM discordance and legal cancellation of zoning were identified and evaluated through judicial precedents. We found that improper use of data and adoption of tolerance caused the cancellations. To remedy these problems, we suggest the disclosure and application of cadastral computerized data instead of serial cadastral maps during LURM production activities to justify the legal adoption of allowable errors. We also recommend the widespread introduction of legal fiction for the rapid production of digital cadastral maps. Zoning cancellation could be minimized through such enhancements, and the map could allow people to visualize elements more conveniently. Moreover, this study aims to expand relevant legal mapping.
Role of Oxidative Stress and Inflammatory Cytokines (TNF-α and IL-6) in Acetic Acid-Induced Ulcerative Colitis in Rats: Ameliorated by Otostegia fruticosa
Authors: Ansari Mohd Nazam , Rehman Najeeb Ur , Karim Aman , Soliman Gamal A. , Ganaie Majid A. , Raish Mohammad , Hamad Abubaker M.
Published: March 2021

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that causes irritation, inflammation, and ulceration in the linings of the colon and rectum. Otostegia fruticosa is traditionally used to treat various disorders in different parts of the Middle East and sub-Saharan Africa. In the present study, we evaluated the ameliorative effects of crude leaves extract of O. fruticosa (OF.Cr) on acetic acid (AA)-induced UC model in Wistar albino rats. Wistar rats were administered orally with either vehicle (10 mL/kg), OF.Cr (200 and 400 mg/kg), or prednisolone (2 mg/kg) once a day for 6 days. On day 6, UC was induced in rats by intrarectal administration of a single dose of 5% AA (1.0 mL). Disease activity index (DAI) was recorded after one day of colitis induction by assessing the symptoms of colitis and then the rats were euthanized by cervical dislocation, and colon tissues were isolated for the histopathological examination and biochemical analysis of oxidative stress parameters and cytokines (Interleukin-6 and Tumor Necrosis Factor-α). OF.Cr pretreatment exhibits significant prevention against UC, as confirmed by a significant decrease of DAI, colonic ulceration, and reduced inflammatory score as compared to the AA-induced colitis rats. Depletion of total glutathione (GSH) levels and catalase (CAT) activities in the colitis group was significantly restored in the OF.Cr treated groups, while increased lipid peroxidation in the colon tissues was significantly reduced. OF.Cr prevented the activation of the IL-6 and TNF-α pathways in the colonic tissues, which were clearly observed by the decreased levels of IL-6 and TNF-α in the OF.Cr treated animals. Hence, OF.Cr could be developed in the future for the treatment of UC.
Mg2+ Doping Effects on the Structural and Dielectric Properties of CaCu3Ti4O12 Ceramics Obtained by Mechanochemical Synthesis
Authors: Dulian Piotr , Bąk Wojciech , Piz Mateusz , Garbarz-Glos Barbara , Sachuk Olena V. , Wieczorek-Ciurowa Krystyna , Lisińska-Czekaj Agata , Czekaj Dionizy
Published: March 2021

In this study, ceramic CaCu3Ti4O12 (CCTO) and CaCu3−xMgxTi4O12 solid solutions in which 0.1 ≤ x ≤ 0.5 were prepared by the mechanochemical method, realized by a high-energy ball milling technique. The effects of the Mg2+ ion concentration and sintering time on the dielectric response in the prepared ceramics were investigated and discussed. It was demonstrated that, by the use of a sufficiently high energy of mechanochemical treatment, it is possible to produce a crystalline product after only 2 h of milling the mixture of the oxide substrates. Both the addition of magnesium ions and the longer sintering time of the mechanochemically-produced ceramics cause excessive grain growth and significantly affect the dielectric properties of the materials. The X-ray diffraction (XRD) analysis showed that all of the as-prepared solid solutions, CaCu3−xMgxTi4O12 (0.0 ≤ x ≤ 0.5), regardless of the sintering time, exhibit a cubic perovskite single phase. The dielectric study showed two major contributions associated with the grains and the grain boundaries. The analysis of the electric modules of these ceramics confirmed the occurrence of Maxwell–Wagner type relaxation, which is dependent on the temperature.
Melting of PCMs Embedded in Copper Foams: An Experimental Study
Authors: Diani Andrea , Rossetto Luisa
Published: March 2021

A smart possible way to cool electronics equipment is represented by passive methods, which do not require an additional power input, such as Phase Change Materials (PCMs). PCMs have the benefit of their latent heat being exploited during the phase change from solid to liquid state. This paper experimentally investigates the melting of different PCMs having different melting temperatures (42, 55 and 64 °C). Two copper foams, having 10 PPI and relative densities of 6.7% and 9.5%, i.e., porosities of 93.3% and 90.5%, respectively, are used to enhance the thermal conductivity of PCMs. The block composed by the PCM and the copper foam is heated from one side, applying three different heat fluxes (10, 15 and 20 kW m−2): the higher the heat flux, the higher the temperature reached by the heated side and the shorter the time for a complete melting of the PCM. The copper foam with a relative density of 9.5% shows slightly better performance, whereas the choice of the melting temperature of the PCM depends on the time during which the passive cooling system must work. The effect of the foam material is also presented: a copper foam presents better thermal performances than an aluminum foam with the same morphological characteristics. Finally, experimental dimensionless results are compared against values predicted by a correlation previously developed.
Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Libya
Authors: Fillo Silvia , Giordani Francesco , Monte Anella , Faggioni Giovanni , De Santis Riccardo , D’Amore Nino , Palomba Stefano , Hamdani Taher , Taloa Kamel , Jumaa Atef Belkhir , Bitrou Siraj , Alaruusi Ahmed , Mad Wadie , Zorgani Abdulaziz , Elahmer Omar , Annajr Badereddin , Bashein Abdalla , Lista Florigio
Published: March 2021

The COVID-19 epidemic started in Libya in March 2020 and rapidly spread. To shed some light on the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) strains circulating in Libya, viruses isolated from 10 patients in this country were sequenced, characterized at the genomic level, and compared to genomes isolated in other parts of the world. As nine genomes out of 10 belonged to the SS1 cluster and one to SS4, three datasets were built. One included only African strains and the other two contained internationally representative SS1 and SS4 genomes. Genomic analysis showed that the Libyan strains have some peculiar features in addition to those reported in other world regions. Considering the countries in which the strains are genetically more similar to the Libyan strains, SARS-CoV-2 could have entered Libya from a North African country (possibly Egypt), sub-Saharan Africa (e.g., Ghana, Mali, Nigeria), the Middle East (e.g., Saudi Arabia), or Asia (India, Bangladesh).
(U-Th)/He Dating of Supergene Iron (Oxyhydr-)Oxides of the Nefza-Sejnane District (Tunisia): New Insights into Mineralization and Mammalian Biostratigraphy
Authors: Yans Johan , Verhaert Michèle , Gautheron Cecile , Antoine Pierre-Olivier , Moussi Béchir , Dekoninck Augustin , Decrée Sophie , Chaftar Hédi-Ridha , Hatira Nouri , Dupuis Christian , Pinna-Jamme Rosella , Jamoussi Fakher
Published: March 2021

The mining district of Nefza-Sejnane (Tunisia) encloses numerous ores and raw material deposits, all formed in relation with successive Fe-rich fluids of meteoric and/or hydrothermal origins. Here, for the first time in Tunisia, (U-Th)/He ages were obtained on supergene goethite from various localities/deposits of the district highlight direct dating of significant weathering episodes during late Tortonian and late Pleistocene. These weathering events are most likely associated with favorable conditions that combine (i) wet climate displaying sufficient meteoric water/fluid; and (ii) regional exhumation, due to large-scale vertical lithospheric movements enhancing the percolation of fluids. Matched with previous works, these results refine the stratigraphic frame for the polymetallic mineralization and clay deposits in the district, confirming the influence of meteoric fluids circulation during the late Cenozoic. As a consequence of the new (U-Th)/He data, we moreover propose a taxonomic and stratigraphic revision of the well-known mammalian fauna from the Fe-rich Douahria locality, suggesting an early Tortonian age for the fossils, i.e., prior to the first episode of meteoric event in the area.