bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges and Strategies for Post-COVID-19 Gender Equity and Sustainable Mobility
Authors: González-Sánchez Guadalupe , Olmo-Sánchez María Isabel , Maeso-González Elvira
Published: February 2021

The COVID-19 pandemic has forced countries around the world to take unprecedented measures to contain it. In particular, its impact on mobility has been enormous, causing a sudden decrease in the number of trips and changes in the choice and use of modes of transport. Furthermore, the effects of this health crisis on the social and economic spheres have aggravated inequalities between population groups, with women being one of the most affected groups, which may accentuate the already known gender gap in mobility. Based on these premises, we carried out a strategic analysis of urban mobility from the perspective of sustainability and gender equity in the context of the pandemic, identifying a set of effective strategies to address the post-COVID-19 urban mobility scenario. To this end, based on the review of the literature and expert opinions, we carried out a Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis that allowed us to formulate 16 strategies after careful consideration of the weaknesses, strengths, threats and opportunities encountered. Our results provide useful recommendations for making successful policy decisions on post-COVID-19 mobility planning towards a more sustainable, equitable and safe model.
How Small and Medium Sized Firms Walk the Path to Hybridity
Authors: Punstein Anna Mateja , Glückler Johannes
Published: February 2021

Customers increasingly prefer the provision of comprehensive solutions over buying goods and services separately. Whereas researchers have closely studied the servitization of large manufacturers, the situation of small and medium sized firms as well as of services firms has been neglected. In contrast to the one-sided view of servitization, we propose a comprehensive view of hybridity to capture the transformation of firms from pure to hybrid products and to focus on SMEs across a wide range of sectors. Based on a survey of 190 SMEs in a highly industrialized southern German region, we find hybrid firms to be more likely than pure firms—both manufacturing and service firms—to engage in a higher scale and scope of innovation activities, to use absorptive capabilities in the appropriation of external knowledge, and to collaborate with partners in the innovation process. We argue that collaboration offers a sustainable path towards hybridity for SMEs, and that territorial hybridity can be a viable path for regions towards sustainable development.
Digital Transformation and Marketing Activities in Small and Medium-Sized Enterprises
Authors: Ziółkowska Marta Joanna
Published: February 2021

Digital transformation which impacts business operations is one of the most fundamental social and economic occurrences of our times. The paper seeks to find out how digital transformation impacts marketing activities in small and medium-sized enterprises (SMEs) and to examine overall changes triggered by digital technology in the marketing concept, its instruments, and activities in SMEs in Poland. The main research question focuses on the direction in which marketing activities performed by organisations evolve nowadays. Analyses and considerations are based on logical inference, examination of results of empirical studies, critical literature review, and author’s market observations. Conducted analyses have demonstrated that, in enterprises covered by the study, digital technologies are deployed in marketing rather widely, although in many instances these technologies belong to the category of traditional tools. IT technologies and digital tools also impact marketing, helping to build relationships with clients and creating the value of each organisation.
Evaluation of Sustainability Principles in Adaptable Re-Functioning: Traditional Residences in Demirel Complex
Authors: Durukan Ayşegül , Ertaş Beşir Şebnem , Koç Altuntaş Selver , Açıkel Mikail
Published: February 2021

Sustainable living is basically being able to construct the balance of protecting and using natural resources. In this way, the heritage value transferred to future generations is formed by the interaction of people and the environment. This is also very important for “architecture”, which expresses sustainability and is an important tool. In addition to the continuity of sustainable architecture and cultural heritage, it is possible to create economic resources and detect sociological data. Local architecture, which bridges the past and the present and best reveals the relationship of people with each other and their environment, has a place in many parts of the world with its rich diversity. Local architecture has an active place in contemporary society with its cultural, socio-economic and concrete identity values. These structures are protected by various strategies and methods and transferred to future generations. One of these methods is adaptive re-use. Within the scope of adaptive re-use, the study examined the principles of sustainability through eight second-degree registered İslamköy residences in the Demirel Complex of İslamköy village in Atabey district of Isparta province in Turkey. Thus, by evaluating three basic principles, environmental, economic and social, in terms of the continuity of local architecture with the sub-parameters determined, it was aimed to reveal the benefits and damages caused by the complex to the settlement in terms of sustainability. In this way, the change and transformation created by re-functioning with the renewal of building materials and typology was examined.
Sustainable Local Exploitation and Innovation on Meat Products Based on the Autochthonous Bovine Breed Jarmelista
Authors: Coutinho Paula , Simões Manuel , Pereira Carlos , Paiva Teresa
Published: February 2021

The Jarmelista autochthonous bovine breed has a sustainable production and is part of the culture of the Portuguese territory, representing a touristic attraction and originating a differentiated beef product that can only be found in a particular region of the country. However rural and livestock population evolution in Portugal’s inland has demonstrated a great regression with consequences for environment and nature conservation. In this context and considering that silvopastoral activity has shaped the natural areas of mountain territories since its beginning, rethinking the importance of such activity has become vital for the territory sustainability. In this perspective, this work presents an analysis of the adaptation and evolution of Jarmelista bovine breed production to current times, perceiving its limitations, challenges, and success potential, supported by a data collection of secondary and primary sources. Despite the natural, healthy, and sustainable value of this particular bovine meat, we observed that is still not recognised by the market or even by the producers. The inability of proving the Jarmelista beef added value within the value chain is the main cause of businesses and consumers sceptic and disbelief in the potential of its economic and tourism contribution. Several possibilities and actions were identified to contradict this path.
Defining, Conceptualizing, and Measuring Organizational Resilience: A Multiple Case Study
Authors: Chen Ruijun , Xie Yaping , Liu Yingqi
Published: February 2021

Organizational resilience is an important means of coping with crises. This concept has received much attention within both academia and industry. However, research on the definition and measurement of organizational resilience is still in the exploratory stage. To date, studies on organizational resilience have yielded mixed conclusions, which makes it difficult to provide specific recommendations for coping with crises. This paper uses an exploratory case study approach to explore the process of organizational resilience among six highly resilient companies: Southwest Airlines, Apple, Microsoft, Starbucks, Kyocera, and Lego. We employed grounded theory to distill the main characteristics of organizational resilience, to explore and validate its structural dimensions, and to develop a measurement scale for organizational resilience. Further, we conducted reliability and validity analysis, exploratory factor analysis, and validation factor analysis on the 526 valid data collected. Results show that organizational resilience includes five dimensions: capital resilience, strategic resilience, cultural resilience, relationship resilience, and learning resilience. The measurement scale has good reliability and validity, which better reflects the notion of organizational resilience. This study bridges the gaps in the existing literature on organizational resilience and its measurement scales, and provides a foundation for future research.
How Corporate Social Responsibility and External Stakeholder Concerns Affect Green Supply Chain Cooperation among Manufacturers: An Interpretive Structural Modeling Analysis
Authors: Huang Xiangmeng , Yang Shuai , Shi Xiaolan
Published: February 2021

The past decade saw an increasing development and improvement of green supply chain, but the environmental performances cannot be achieved by single enterprises. Therefore, it is necessary to find out the influencing factors that hinder the cooperation of green supply chain, so as to make full use of these influencing factors to improve environmental performance. In consultation with supply chain management practitioners and academics, this paper establishes a set of 19 influencing factors for green supply chain cooperation among Chinese manufacturers The corporate social responsibility as internal effect and external stakeholder concern as external effect is considered in this study and the interpreted structural model (ISM) method is used to analyze the interaction among these influencing factors and its impact on green supply chain cooperation. This study aims to identify the most significant impacts on environmental issues with supply chain partners and to understand how these impacts can help improve the environmental performance throughout the supply chain.
Systemic Modeling of the Peace–Development Nexus
Authors: Amadei Bernard
Published: February 2021

As we enter the third decade of the 21st century, the value proposition of promoting sustainability and peace in the world has become more imperative than ever. It is an appropriate time to pause and reflect on what a post-pandemic COVID-19 world will look like and what constitutes a new mindset toward a more sustainable, stable, peaceful, and equitable world where all humans live with dignity and at peace. As emphasized in this paper, the new mindset must acknowledge that sustainability and peace are two entangled states of dynamic equilibrium. It is hard to envision a sustainable world that is not peaceful and a peaceful world that has not endorsed sustainable practices. This paper looks more specifically at the value proposition of adopting a systems approach to capture the linkages between selected development sectors (e.g., SDGs) and peace sectors (e.g., positive, negative, and cultural). Basic system dynamics (SD) models are presented to illustrate the peace–development nexus dynamics. The models are general enough to be used for different contexts and scales.
Optimal Coordinated Planning of Energy Storage and Tie-Lines to Boost Flexibility with High Wind Power Integration
Authors: Alismail Fahad , Abdulgalil Mohamed A. , Khalid Muhammad
Published: February 2021

Since renewable power is intermittent and uncertain, modern grid systems need to be more elegant to provide a reliable, affordable, and sustainable power supply. This paper introduces a robust optimal planning strategy to find the location and the size of an energy storage system (ESS) and feeders. It aims to accommodate the wind power energy integration to serve the future demand growth under uncertainties. The methodology was tested in the IEEE RTS-96 system and the simulation results demonstrate the effectiveness of the proposed optimal sizing strategy. The findings validate the improvements in the power system reliability and flexibility.
Recent Advances in Mycotoxin Analysis and Detection of Mycotoxigenic Fungi in Grapes and Derived Products
Authors: Kizis Dimosthenis , Vichou Aikaterini-Eleni , Natskoulis Pantelis I.
Published: February 2021

Mycotoxins are secondary metabolites of filamentous fungi that can cause toxic effects in human and animal health. Most of the filamentous fungi that produce these mycotoxins belong to four genera, namely, Aspergillus, Penicillium, Fusarium, and Alternaria. Mycotoxigenic fungi, along with mycotoxins, create a constant and serious economic threat for agriculture in many terms, counting product losses due to crop contamination and food spoilage, as well malnutrition when considering nutritional quality degradation. Given the importance of robust and precise diagnostics of mycotoxins and the related producing fungi in the grape food chain, one of the most important agricultural sectors worldwide, the present review initially delivers a comprehensive presentation of mycotoxin reports on grape and derived products, including a wide range of commodities such as fresh grapes, raisins, wine, juices, and other processed products. Next, based on worldwide regulations’ requirements for mycotoxins, and referring to the relative literature, this work presents methodological approaches for mycotoxin determination, and stresses major methods for the detection of fungal species responsible for mycotoxin production. The principle of function and basic technical background on the available analytical and molecular biology techniques developed—including chromatography, mass spectrometry, immunochemical-based assays, biosensors, and molecular assays—is briefly given, and references for their application to grape and derived product testing are highlighted.
Exploring the Potential of Neglected Local Endemic Plants of Three Mediterranean Regions in the Ornamental Sector: Value Chain Feasibility and Readiness Timescale for Their Sustainable Exploitation
Authors: Krigas Nikos , Tsoktouridis Georgios , Anestis Ioannis , Khabbach Abdelmajid , Libiad Mohamed , Megdiche-Ksouri Wided , Ghrabi-Gammar Zeineb , Lamchouri Fatima , Tsiripidis Ioannis , Tsiafouli Maria A. , El Haissoufi Mohamed , Bourgou Soumaya
Published: February 2021

The neglected and underutilized plants (NUPs) have never been mainstreamed by researchers, politicians and stakeholders for sustainable exploitation in the ornamental-horticultural sector. This study focused on 399 local endemic plants of three Mediterranean regions (Crete, Mediterranean coast-Rif of Morocco, Tunisia), with the aim to develop a new scheme for their multifaceted ornamental-horticultural evaluation facilitating their sustainable exploitation. The methodological scheme was developed within three multidisciplinary co-creative workshops by experts and was adjusted by end-users. The developed scheme uses point and weighted scoring of several attributes relevant to biological and ornamental-horticultural characteristics and concerns three ranking levels: (i) ornamental-horticultural potential (general or subsector-specific; 20 attributes), (ii) sustainable exploitation feasibility (12 attributes) and (iii) readiness timescale (after gap and SWOT analyses) in creating value chains in short-, medium- or long-term. The analysis of the data illustrated two example-cases of already achieved sustainable exploitation with established value chains; outlined the prospects for sustainable exploitation of 18 and 23 local endemic NUPs in short-term and medium-term, respectively; and identified 86 taxa with reachable possibilities in the long-term. The proposed multifaceted evaluation scheme can be applied for the valorisation of NUPs in other areas and may help to define priorities and to identify opportunities and gaps for their sustainable exploitation.
Analytic Hierarchy Process-Based Airport Ground Handling Equipment Purchase Decision Model
Authors: Tao Yu-Jwo , Lee Hsuan-Shih , Tu Chang-Shu
Published: February 2021

The Airport ground handling services (AGHS) equipment supplier provider selection requires a safety guarantee in terms of the daily operations AGHS provider. AGHS providers seek to avoid aircraft damage and airline delays and ensure the provision of reliable and high-quality services. The primary objective of this paper was to develop purchasing decision model of the analytic hierarchy process (AHP), AHP-fuzzy linear programming (FLP), and AHP-Taguchi loss function (TLF) multi-choice goal programming (MCGP) purchase decision models to help the AGHS purchasing managers in selecting the best AGHS equipment supplier provider. The constructed models were assessed, and results obtained for the AHP-FLP and AHP-TLF-MCGP models were compared. We conducted a real-world example of supplier selection by an AGHS company by using the proposed models. The proposed model provides useful information and has practical value for AGHS providers.
The Use of Ethanol as an Alternative Fuel for Small Turbojet Engines
Authors: Andoga Rudolf , Főző Ladislav , Schrötter Martin , Szabo Stanislav
Published: February 2021

The use of alternative fuels to traditional kerosene-based ones in turbo-jet engines is currently being widely explored and researched. However, the application of alternative fuels in the area of small turbojet engines with thrust ratings up to 2 kilo-newtons, which are used as auxiliary power units or to propel small aircraft or drones, is not as well researched. This paper explores the use of ethanol as a sustainable fuel and its effects on the operation of a small turbojet engine under laboratory conditions. Several concentrations of ethanol and JET A-1 mixtures are explored to study the effects of this fuel on the basic parameters of a small turbojet engine. The influence of the different concentrations of the mixture on the start-up process, speed of the engine, exhaust gas temperature, and compressor pressure are evaluated. The measurements shown in the article represent a pilot study, the results of which show that ethanol can be reliably used as an alternative fuel only when its concentration in a mixture with traditional fuel is lower than 40%, yielding positive effects on the operating temperatures and small negative effects on the speed or thrust of the engine.
An Exploration of Social License to Operate (SLTO) Measurement in the Port Industry: The Case of North America
Authors: Moeremans Bruno , Dooms Michaël
Published: February 2021

In this paper, we develop exploratory research to improve the understanding of actual practices applied in the port industry relating to local communities’ perception measurement and public engagement, aiming at maintaining and fostering relationships with local communities. The application of such practices would allow port managing bodies to improve their strategic alignment with the needs and requirements of their local communities. To this end, we distributed a survey to North American port managing bodies and terminal operators. The survey, answered by 37 respondents, follows a structure defined by critical elements affecting stakeholder perceptions and acceptability in relation to a project or an ongoing business activity. The results disclose differences in social license to operate measurement and public engagement practices between port managing bodies and terminal operators. Furthermore, follow-up interviews were conducted with eight port managing bodies in order to capture the value added and the barriers to engage with local communities. Finally, the study enables benchmarking possibilities both within the sample and on a global level, giving an indication and assessment of the respondents’ competitive positions regarding stakeholder perceptions, communication, and engagement practices, and the steps to be taken in order to strengthen any strategic and competitive state.
Agency in Circular City Ecosystems—A Rationalities Perspective
Authors: Hirvensalo Antero , Teerikangas Satu , Reynolds Noelia-Sarah , Kalliomäki Helka , Mäntysalo Raine , Mattila Hanna , Granqvist Kaisa
Published: February 2021

The concept of agency is increasingly used in the literature on sustainability transitions. In this paper, we add to that discussion by arguing that the concept of rationality opens new avenues to theorizing relational agency in transitions toward a circular economy. To this end, we compare rationality conceptions from management (e.g., collaboration and competition) with critical theory perspectives on rationality (e.g., instrumental and communicative rationality). This leads us to develop a typology matrix for describing plural rationalities underpinning relational agency. We illustrate this typology using excerpts from an in-depth case study of an ongoing city-coordinated ecosystem that develops a smart technology-enabled urban area based on the principles of circularity. The first contribution of this interdisciplinary paper is to offer a rational perspective on theorizing the antecedents of relational agency in circular economy transitions, where communicatively rational action enables agency and change. Secondly, our paper contributes to the literature on circular cities through conceptualizing circular transition as simultaneous collaboration and competition. Thirdly, our paper introduces a dyadic perspective on rationality to the literature on coopetition and provides an operating space from which professionals can navigate, depending on the type of coopetitive situation.
Revealing Development Trends in Blockchain-Based 5G Network Technologies through Patent Analysis
Authors: Gao Fei , Chen De-Li , Weng Min-Hang , Yang Ru-Yuan
Published: February 2021

The fifth-generation (5G) network has special communication and security requirements including high reliability, low latency, precise automatic control, secure covert transmission, and evidence traceability. The 5G network combined with blockchain technology just meets this demand, so it is driving a rapidly growing volume of patent applications. This study proposes application scenarios, architecture diagrams, and patent analysis methods for blockchain-based 5G network technologies, beginning with a network architecture using mobile edge computing (MEC) and blockchain as independent platform components to solve MEC load pressure. In the patent analysis, a patent cluster map of blockchain-based 5G networks is proposed to analyze the intersection of technical application fields. The bottleneck period of technological development is presented for leading countries and enterprises in the technological development of blockchain-based 5G network, highlighting relative advantages and disadvantages. Specifically, to extract the core international patent classification (IPC) key technologies and their mutual interrelatedness, we use network topology analysis to establish an IPC network topology diagram through node global and local topology characteristics, thus revealing hotspots of IPC technology research and the characteristics of the technology relationship system. The findings provide a very useful reference for the formulation of government strategy to assist in the implementation and development of blockchain-based 5G network technologies for future smart cities.
Fuzzy Synthetic Evaluation of the Critical Success Factors for the Sustainability of Public Private Partnership Projects in China
Authors: Deng Binchao , Zhou Dongjie , Zhao Jiachen , Yin Yilin , Li Xiaoyu
Published: February 2021

Public Private Partnership (PPP) projects have attracted wide attention from academia and industry over the past 20 years, however, they have been plagued by certain factors. This study identified, classified, and evaluated the success factors that may affect PPP projects for achieving sustainability. First, a list of 32 critical success factors were categorized into 3 groups, then a questionnaire survey was conducted, with 108 responses received from experts, researchers, and PPP project managers in China. Second, using a fuzzy synthetic evaluation (FSE) method, stakeholder relationships (A1–A10), external environmental (B1–B8), and project management of a special purpose vehicle (C1–C14) collected data at three different factor group locations in PPP projects were used in this evaluation. The results obtained nine top factors: private sector financing capacity, government credit, government commitment or guarantee, completeness of legal framework, available financial markets, the feasibility study report and implementation, effectiveness of risk management, project investment, and cost control and revenue distribution. It was demonstrated that fuzzy synthetic evaluation techniques are quite appropriate techniques for PPP projects. The research findings should impact on policy development towards PPP and Private Finance Initiative (PFI) project governance.
Achieving Sustainable Development Goals (SDGs) among Walking and Talking
Authors: Caputo Fabio , Leopizzi Rossella
Published: February 2021

The last years have seen an increasing consciousness about the need to rethink the global economy [...]
Analysis of Dynamic Wireless Power Transfer Systems Based on Behavioral Modeling of Mutual Inductance
Authors: Di Capua Giulia , Maffucci Antonio , Stoyka Kateryna , Di Mambro Gennaro , Ventre Salvatore , Cirimele Vincenzo , Freschi Fabio , Villone Fabio , Femia Nicola
Published: February 2021

This paper proposes a system-level approach suitable to analyze the performance of a dynamic Wireless Power Transfer System (WPTS) for electric vehicles, accounting for the uncertainty in the vehicle trajectory. The key-point of the approach is the use of an analytical behavioral model that relates mutual inductance between the coil pair to their relative positions along the actual vehicle trajectory. The behavioral model is derived from a limited training data set of simulations, by using a multi-objective genetic programming algorithm, and is validated against experimental data, taken from a real dynamic WPTS. This approach avoids the massive use of computationally expensive 3D finite element simulations, that would be required if this analysis were performed by means of look-up tables. This analytical model is here embedded into a system-level circuital model of the entire WPTS, thus allowing a fast and accurate analysis of the sensitivity of the performance as the actual vehicle trajectory deviates from the nominal one. The system-level analysis is eventually performed to assess the sensitivity of the power and efficiency of the WPTS to the vehicle misalignment from the nominal trajectory during the dynamic charging process.
Multi-Scale and Multi-Branch Convolutional Neural Network for Retinal Image Segmentation
Authors: Jiang Yun , Liu Wenhuan , Wu Chao , Yao Huixiao
Published: February 2021

The accurate segmentation of retinal images is a basic step in screening for retinopathy and glaucoma. Most existing retinal image segmentation methods have insufficient feature information extraction. They are susceptible to the impact of the lesion area and poor image quality, resulting in the poor recovery of contextual information. This also causes the segmentation results of the model to be noisy and low in accuracy. Therefore, this paper proposes a multi-scale and multi-branch convolutional neural network model (multi-scale and multi-branch network (MSMB-Net)) for retinal image segmentation. The model uses atrous convolution with different expansion rates and skip connections to reduce the loss of feature information. Receiving domains of different sizes captures global context information. The model fully integrates shallow and deep semantic information and retains rich spatial information. The network embeds an improved attention mechanism to obtain more detailed information, which can improve the accuracy of segmentation. Finally, the method of this paper was validated on the fundus vascular datasets, DRIVE, STARE and CHASE datasets, with accuracies/F1 of 0.9708/0.8320, 0.9753/0.8469 and 0.9767/0.8190, respectively. The effectiveness of the method in this paper was further validated on the optic disc visual cup DRISHTI-GS1 dataset with an accuracy/F1 of 0.9985/0.9770. Experimental results show that, compared with existing retinal image segmentation methods, our proposed method has good segmentation performance in all four benchmark tests.
Nonlinear Dynamics of Wave Packets in Tunnel-Coupled Harmonic-Oscillator Traps
Authors: Hacker Nir , Malomed Boris A.
Published: February 2021

We consider a two-component linearly coupled system with the intrinsic cubic nonlinearity and the harmonic-oscillator (HO) confining potential. The system models binary settings in BEC and optics. In the symmetric system, with the HO trap acting in both components, we consider Josephson oscillations (JO) initiated by an input in the form of the HO’s ground state (GS) or dipole mode (DM), placed in one component. With the increase of the strength of the self-focusing nonlinearity, spontaneous symmetry breaking (SSB) between the components takes place in the dynamical JO state. Under still stronger nonlinearity, the regular JO initiated by the GS input carries over into a chaotic dynamical state. For the DM input, the chaotization happens at smaller powers than for the GS, which is followed by SSB at a slightly stronger nonlinearity. In the system with the defocusing nonlinearity, SSB does not take place, and dynamical chaos occurs in a small area of the parameter space. In the asymmetric half-trapped system, with the HO potential applied to a single component, we first focus on the spectrum of confined binary modes in the linearized system. The spectrum is found analytically in the limits of weak and strong inter-component coupling, and numerically in the general case. Under the action of the coupling, the existence region of the confined modes shrinks for GSs and expands for DMs. In the full nonlinear system, the existence region for confined modes is identified in the numerical form. They are constructed too by means of the Thomas–Fermi approximation, in the case of the defocusing nonlinearity. Lastly, particular (non-generic) exact analytical solutions for confined modes, including vortices, in one- and two-dimensional asymmetric linearized systems are found. They represent bound states in the continuum.
The Inclined Factors of Magnetic Field and Shrinking Sheet in Casson Fluid Flow, Heat and Mass Transfer
Authors: Parvin Shahanaz , Mohamed Isa Siti Suzilliana Putri , Arifin Norihan Md , Md Ali Fadzilah
Published: February 2021

The development of the mathematical modeling of Casson fluid flow and heat and mass transfer is presented in this paper. The model is subjected to the following physical parameters: shrinking parameter, mixed convection, concentration buoyancy ratio parameter, Soret number, and Dufour number. This model is also subjected to the inclined magnetic field and shrinking sheet at a certain angle projected from the y- and x-axes, respectively. The MATLAB bvp4c program is the main mathematical program that was used to obtain the final numerical solutions for the reduced ordinary differential equations (ODEs). These ODEs originate from the governing partial differential equations (PDEs), where the transformation can be achieved by applying similarity transformations. The MATLAB bvp4c program was also implemented to develop stability analysis, where this calculation was executed to recognize the most stable numerical solution. Numerical graphics were made for the skin friction coefficient, local Nusselt number, local Sherwood number, velocity profile, temperature profile, and concentration profile for certain values of the physical parameters. It is found that all the governed parameters affected the variations of the Casson fluid flow, heat transfer, mass transfer, and the profiles of velocity, temperature, and concentration. In addition, a stable solution can be applied to predict the impact of physical parameters on the actual fluid model by using a mathematical fluid model.
High-Energy Neutrino Astronomy—Baikal-GVD Neutrino Telescope in Lake Baikal
Authors: Stasielak Jarosław , Malecki Paweł , Naumov Dmitry , Allakhverdian Vladimir , Karnakova Alexandra , Kopański Konrad , Noga Wojciech ,   on behalf of the Baikal-GVD Collaboration
Published: February 2021

High-energy neutrino astronomy is a fascinating new field of research, rapidly developing over recent years. It opens a new observation window on the most violent processes in the universe, fitting very well to the concept of multi-messenger astronomy. This may be exemplified by the recent discovery of the high-energy neutrino emissions from the γ-ray loud blazar TXS 0506+056. Constraining astrophysical neutrino fluxes can also help to understand the long-standing mystery of the origin of the ultra-high energy cosmic rays. Astronomical studies of high-energy neutrinos are carried out by large-scale next-generation neutrino telescopes located in different regions of the world, forming a global network of complementary detectors. The Baikal-GVD, being currently the largest neutrino telescope in the Northern Hemisphere and still growing up, is an important constituent of this network. This paper briefly reviews working principles, analysis methods, and some selected results of the Baikal-GVD neutrino telescope.
Geometric Justification of the Fundamental Interaction Fields for the Classical Long-Range Forces
Authors: Gueorguiev Vesselin G. , Maeder Andre
Published: February 2021

Based on the principle of reparametrization invariance, the general structure of physically relevant classical matter systems is illuminated within the Lagrangian framework. In a straightforward way, the matter Lagrangian contains background interaction fields, such as a 1-form field analogous to the electromagnetic vector potential and symmetric tensor for gravity. The geometric justification of the interaction field Lagrangians for the electromagnetic and gravitational interactions are emphasized. The generalization to E-dimensional extended objects (p-branes) embedded in a bulk space M is also discussed within the light of some familiar examples. The concept of fictitious accelerations due to un-proper time parametrization is introduced, and its implications are discussed. The framework naturally suggests new classical interaction fields beyond electromagnetism and gravity. The simplest model with such fields is analyzed and its relevance to dark matter and dark energy phenomena on large/cosmological scales is inferred. Unusual pathological behavior in the Newtonian limit is suggested to be a precursor of quantum effects and of inflation-like processes at microscopic scales.
Interaction between Styrofoam and Microalgae Spirulina platensis in Brackish Water System
Authors: Hadiyanto Hadiyanto , Haris Amnan , Muhammad Fuad , Afiati Norma , Khoironi Adian
Published: February 2021

Styrofoam is a thermoplastic with special characteristics; it is an efficient insulator, is extremely lightweight, absorbs trauma, is bacteria resistant, and is an ideal packaging material, compared to other thermoplastics. The aim of this study was to analyze the interaction between Styrofoam and S. platensis. The study examined the growth of S. platensis under Styrofoam stress, changes in Styrofoam functional groups, and their interactions. The research method was culture carried out in brackish water (12 mg/L salinity) for 30 days. S. platensis yields were tested by FTIR and SEM-EDX and Styrofoam samples by FTIR. The results showed the highest growth rate of S. platensis in cultures treated with 150 mg Styrofoam that is 0.0401 day−1. FTIR analysis shows that there has been a change in the functional group on Styrofoam. At a wavelength of 3400–3200 cm−1 corresponds to the alcohol group and there was an open cyclic chain shown by the appearance of a wavelength at 1680–1600 cm−1 assignment to alkene. SEM-EDX test results show that Styrofoam can be a resource of nutrition, especially carbon for S. platensis to photosynthesize. Increased carbon content of 24.56% occurred in culture, meanwhile, Styrofoam is able to damage S. platensis cells.
Perfluoroalkyl Acid Binding with Peroxisome Proliferator-Activated Receptors α, γ, and δ, and Fatty Acid Binding Proteins by Equilibrium Dialysis with a Comparison of Methods
Authors: Khazaee Manoochehr , Christie Emerson , Cheng Weixiao , Michalsen Mandy , Field Jennifer , Ng Carla
Published: February 2021

The biological impacts of per- and polyfluorinated alkyl substances (PFAS) are linked to their protein interactions. Existing research has largely focused on serum albumin and liver fatty acid binding protein, and binding affinities determined with a variety of methods show high variability. Moreover, few data exist for short-chain PFAS, though their prevalence in the environment is increasing. We used molecular dynamics (MD) to screen PFAS binding to liver and intestinal fatty acid binding proteins (L- and I-FABPs) and peroxisome proliferator activated nuclear receptors (PPAR-α, -δ and -γ) with six perfluoroalkyl carboxylates (PFCAs) and three perfluoroalkyl sulfonates (PFSAs). Equilibrium dissociation constants, KDs, were experimentally determined via equilibrium dialysis (EqD) with liquid chromatography tandem mass spectrometry for protein-PFAS pairs. A comparison was made between KDs derived from EqD, both here and in literature, and other in vitro approaches (e.g., fluorescence) from literature. EqD indicated strong binding between PPAR-δ and perfluorobutanoate (0.044 ± 0.013 µM) and perfluorohexane sulfonate (0.035 ± 0.0020 µM), and between PPAR-α and perfluorohexanoate (0.097 ± 0.070 µM). Unlike binding affinities for L-FABP, which increase with chain length, KDs for PPARs showed little chain length dependence by either MD simulation or EqD. Compared with other in vitro approaches, EqD-based KDs consistently indicated higher affinity across different proteins. This is the first study to report PPARs binding with short-chain PFAS with KDs in the sub-micromolar range.
Major Determinants of Airway Epithelial Cell Sensitivity to S. aureus Alpha-Toxin: Disposal of Toxin Heptamers by Extracellular Vesicle Formation and Lysosomal Degradation
Authors: Möller Nils , Ziesemer Sabine , Hentschker Christian , Völker Uwe , Hildebrandt Jan-Peter
Published: February 2021

Alpha-toxin is a major virulence factor of Staphylococcus aureus. Monomer binding to host cell membranes results in the formation of heptameric transmembrane pores. Among human model airway epithelial cell lines, A549 cells were most sensitive toward the toxin followed by 16HBE14o- and S9 cells. In this study we investigated the processes of internalization of pore-containing plasma membrane areas as well as potential pathways for heptamer degradation (lysosomal, proteasomal) or disposal (formation of exosomes/micro-vesicles). The abundance of toxin heptamers upon applying an alpha-toxin pulse to the cells declined both in extracts of whole cells and of cellular membranes of S9 cells, but not in those of 16HBE14o- or A549 cells. Comparisons of heptamer degradation rates under inhibition of lysosomal or proteasomal degradation revealed that an important route of heptamer degradation, at least in S9 cells, seems to be the lysosomal pathway, while proteasomal degradation appears to be irrelevant. Exosomes prepared from culture supernatants of toxin-exposed S9 cells contained alpha-toxin as well as low amounts of exosome and micro-vesicle markers. These results indicate that lysosomal degradation of internalized toxin heptamers may be the most important determinant of toxin-resistance of some types of airway epithelial cells.
A New Peritoneal Dialysis Solution Containing L-Carnitine and Xylitol for Patients on Continuous Ambulatory Peritoneal Dialysis: First Clinical Experience
Authors: Rago Carmela , Lombardi Teresa , Di Fulvio Giorgia , Di Liberato Lorenzo , Arduini Arduino , Divino-Filho José C. , Bonomini Mario
Published: February 2021

Peritoneal dialysis (PD) is a feasible and effective renal replacement therapy (RRT) thanks to the dialytic properties of the peritoneal membrane (PM). Preservation of PM integrity and transport function is the key to the success of PD therapy, particularly in the long term, since the prolonged exposure to unphysiological hypertonic glucose-based PD solutions in current use is detrimental to the PM, with progressive loss of peritoneal ultrafiltration capacity causing technique failure. Moreover, absorbing too much glucose intraperitoneally from the dialysate may give rise to a number of systemic metabolic effects. Here we report the preliminary results of the first clinical experience based on the use in continuous ambulatory PD (CAPD) patients of novel PD solutions obtained through partly replacing the glucose load with other osmotically active metabolites, such as L-carnitine and xylitol. Ten CAPD patients were treated for four weeks with the new solutions. There was good tolerance to the experimental PD solutions, and no adverse safety signals were observed. Parameters of dialysis efficiency including creatinine clearance and urea Kt/V proved to be stable as well as fluid status, diuresis, and total peritoneal ultrafiltration. The promising tolerance and local/systemic advantages of using L-carnitine and xylitol in the PD solution merit further research.
Staphylococcus aureus Isolated from Ruminants with Mastitis in Northern Greece Dairy Herds: Genetic Relatedness and Phenotypic and Genotypic Characterization
Authors: Kotzamanidis Charalampos , Vafeas George , Giantzi Virginia , Anastasiadou Sofia , Mygdalias Stavros , Malousi Andigoni , Loukia Ekateriniadou , Daniel Sergelidis , Zdragas Antonios
Published: February 2021

Staphylococcus aureus is the most common mastitis-related pathogen in dairy cattle, goats, and sheep worldwide. However, the population structure and genomic characteristics of mastitis-associated S. aureus in small ruminants are limited. Furthermore, the genotypic and phenotypic characteristics involved in the pathogenicity of S. aureus have been thoroughly defined, yet their association with the severity of mastitis is not fully established. Here, we performed genotyping by pulsed-field gel electrophoresis (PFGE) and spa analyses to assess the genetic diversity and relatedness of 162 S. aureus strains recovered from clinical mastitis (CM) and subclinical mastitis (SCM) cases from goats, sheep, and bovines. PFGE analysis revealed 108 distinguishable pulsotypes and 3 main clusters that comprised isolates from the three host species, while according to spa typing, 32 different spa types were identified. Genotypic analysis revealed a spreading of genetically related or indistinguishable S. aureus strains among ovine, caprine, and bovine farms of distant geographical regions. In total, 28 different staphylococcal enterotoxin (SE) gene profiles were observed, revealing a diverse range of SE genes among isolates. By evaluating the antimicrobial resistance, we found low phenotypic antimicrobial resistance among all ruminant isolates. We also performed multiple correspondence analysis, which indicated that the presence of the sec gene, biofilm production, and high autoaggregation ability are associated with CM cases.
Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats
Authors: Pastor Laura , Vettorazzi Ariane , Guruceaga Elizabeth , López de Cerain Adela
Published: February 2021

The mycotoxin ochratoxin A (OTA) is a potent nephrocarcinogen, mainly in male rats. The aim of this study was to determine the time course of gene expression (GeneChip® Rat Gene 2.0 ST Array, Affymetrix) in kidney samples from male and female F344 rats, treated daily (p.o) with 0.50 mg/kg b.w. (body weight) of OTA for 7 or 21 days, and evaluate if there were differences between both sexes. After OTA treatment, there was an evolution of gene expression in the kidney over time, with more differentially expressed genes (DEG) at 21 days. The gene expression time course was different between sexes with respect to the number of DEG and the direction of expression (up or down): the female response was progressive and consistent over time, whereas males had a different early response with more DEG, most of them up-regulated. The statistically most significant DEG corresponded to metabolism enzymes (Akr1b7, Akr1c2, Adh6 down-regulated in females; Cyp2c11, Dhrs7, Cyp2d1, Cyp2d5 down-regulated in males) or transporters (Slc17a9 down-regulated in females; Slco1a1 (OATP-1) and Slc51b and Slc22a22 (OAT) down-regulated in males). Some of these genes had also a basal sex difference and were over-expressed in males or females with respect to the other sex.
Gravitoelectromagnetic Knot Fields
Authors: Crişan Adina , Godinho Cresus , Vancea Ion
Published: February 2021

We construct a class of knot solutions of the time-dependent gravitoelectromagnetic (GEM) equations in vacuum in the linearized gravity approximation by analogy with the Rañada–Hopf fields. For these solutions, the dual metric tensors of the bi-metric geometry of the gravitational vacuum with knot perturbations are given and the geodesic equation as a function of two complex parameters of the time-dependent GEM knots are calculated. By taking stationary potentials, which formally amount to particularizing to time-independent GEM equations, we obtain a set of stationary fields subjected to constraints from the time-dependent GEM knots. Finally, the Landau–Lifshitz pseudo-tensor and a scalar invariant of the static fields are computed.
The Quality of Life Definition: Where Are We Going?
Authors: Cai Tommaso , Verze Paolo , Bjerklund Johansen Truls E.
Published: February 2021

The quality of life (QoL) concept now includes new aspects related to patients’ well-being because QoL has become more of a personal perception than an an objective and measurable entity. Here, we discuss the principal aspects of QoL-related aspects in urology and andrology by using a narrative review. Some aspects concerning the QoL are essential when managing uro-andrological patients. The aim of treatments should not only include the absence of disease or symptoms relief but also the improvement of a patient’s QoL with regard to his/her internal status and relationship with others. In this sense, any therapeutic approach should be based on the patient’s perspectives and not only on the instrumental and laboratory findings. Finally, we discussed the role of a patient’s sexual partner adding an extra dimension to the patient-centerd approach as part of the QoL concept in andrology.
Identification of Host Factors Associated with the Development of Equine Herpesvirus Myeloencephalopathy by Transcriptomic Analysis of Peripheral Blood Mononuclear Cells from Horses
Authors: Zarski Lila M. , Giessler Kim S. , Jacob Sarah I. , Weber Patty Sue D. , McCauley Allison G. , Lee Yao , Soboll Hussey Gisela
Published: February 2021

Equine herpesvirus-1 is the cause of respiratory disease, abortion, and equine herpesvirus myeloencephalopathy (EHM) in horses worldwide. EHM affects as many as 14% of infected horses and a cell-associated viremia is thought to be central for EHM pathogenesis. While EHM is infrequent in younger horses, up to 70% of aged horses develop EHM. The aging immune system likely contributes to EHM pathogenesis; however, little is known about the host factors associated with clinical EHM. Here, we used the “old mare model” to induce EHM following EHV-1 infection. Peripheral blood mononuclear cells (PBMCs) of horses prior to infection and during viremia were collected and RNA sequencing with differential gene expression was used to compare the transcriptome of horses that did (EHM group) and did not (non-EHM group) develop clinical EHM. Interestingly, horses exhibiting EHM did not show respiratory disease, while non-EHM horses showed significant respiratory disease starting on day 2 post infection. Multiple immune pathways differed in EHM horses in response to EHV-1. These included an upregulation of IL-6 gene expression, a dysregulation of T-cell activation through AP-1 and responses skewed towards a T-helper 2 phenotype. Further, a dysregulation of coagulation and an upregulation of elements in the progesterone response were observed in EHM horses.