bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis de los defectos congénitos en Colombia, 2015-2017
Authors: Avila-Mellizo Greace-Alejandra , Rozo-Gutierrez Nathaly , Forero-Motta Diana Alexa
Published: August 2022

Introducción: Los defectos congénitos son alteraciones del desarrollo que se generan en la vida intrauterina, tienen un alto impacto en la mortalidad infantil. La Organización Panamericana de Salud ha definido que la vigilancia en salud pública es una de las herramientas fundamentales para obtener estimaciones más precisas sobre la prevalencia del evento. Metodología: Estudio descriptivo retrospectivo con base en la notificación individual semanal de casos al Sistema de Vigilancia en Salud Pública (Sivigila) del evento 215 – Defectos congénitos de los años 2015, 2016 y 2017. Resultados: La notificación de defectos congénitos en Colombia ha aumentado un 39,9% entre 2015 y 2017 con una tasa de prevalencia para el último año de 106,6 casos por 10.000 nacidos vivos. Las tasas de prevalencia más altas se encontraron en cuatro grupos diferentes: 1) menores de sexo masculino, 2) pertenencia étnica indígena, 3) hijos de madres no aseguradas al sistema de salud, 4) hijos de madres con edades mayores de 35 años. Así mismo los defectos congénitos del sistema osteomuscular, sistema circulatorio y sistema nervioso central presentaron la mayor tasa de prevalencia. Discusión: las mayores tasas de prevalencia identificadas en algunos grupos poblacionales son consistentes con otros estudios realizados en la región, y a su vez pueden ser relacionados con las condiciones de vulnerabilidad que limitan posiblemente la falta de oportunidad y acceso a los servicios de salud.
Masa muscular y control autonómico cardiaco en personas jóvenes en reposo y postejercicio
Authors: Rodríguez-Triviño Claudia Yaneth , Jiménez Camilo Alberto , Veloza-Manchola Laura Katherine , Quiñónez-Bohórquez Daniel , Polania-Pérez Juan Felipe
Published: August 2022

Introducción: la variabilidad de la frecuencia cardiaca (VFC) es usada en pacientes con riesgo de muerte súbita y en el entrenamiento de deportistas para el análisis del control autonómico cardiaco. Objetivo: correlacionar la composición corporal y la VFC en personas jóvenes no deportistas, sin evidencia de enfermedad cardiovascular establecida, en reposo y postejercicio. Metodología: este es un estudio descriptivo de corte transversal correlacional, con 24 hombres y 27 mujeres. Se analizó el porcentaje de grasa corporal, los kilogramos de masa muscular a través de bioimpedancia. La medición de la VFC se realizó con Powerlab® y con el software Labchart®. Los registros se exportaron a KUBIOS® para el análisis de la VFC. Resultados: la edad promedio de los participantes fue de 22 años, los hombres con 22,3 años (DE ± 1,5) y las mujeres con 22,1 años (DE ± 1,6). Se encontró que la masa muscular tuvo una correlación positiva moderada (0,4) con el rango alta frecuencia (HF) (p = 0,003), HF aumenta cuando la masa muscular lo hace; la desviación estándar de los RR (SDNN), entre otras, tuvo una correlación positiva baja. Conclusiones: según los hallazgos de este estudio, la composición corporal y la VFC en adultos sanos en reposo están relacionadas; la masa muscular se correlacionó positivamente con la VFC, lo que podría mejorar el predominio parasimpático en personas con mayores masas musculares en comparación con personas con menos masa muscular.
Research on Talent Evaluation Technology Based on Systematic Co-Reaction Force Method
Authors: Peng Sumian
Published: August 2022

In the multi-method and multi-model collaborative matrix model clustering calculation analysis, the talent evaluation sample data itself is used as a dictionary to re-represent each sample data, and the sample-based collaborative data reconstruction is carried out, and the talent evaluation reconstruction coefficient matrix is sparse, Low rank and smooth constraints greatly improve the reliability and validity of enterprise talent evaluation samples[1]. The main purpose of this paper is to design and construct a multi-model and multi-view collaborative similarity matrix for enterprise talent assessment, to mine the relationship between talent assessment samples, and to achieve clustering and collaboration of assessment samples.
Research on Visualization Management of Human Resources Based on Big Data Neural Network Technology
Authors: Zhang Jing
Published: August 2022

Nowadays, the number of internet of things (IoT) connected devices continues to increase exponentially. However, the core underlying wireless network technologies that enable IoT devices to achieve such growth and wide applications face numerous challenging deployment requirements such as operating range, power consumption, and cost. Low-power wide-area network (LPWAN) technologies enable long-distance, low-power, and low data transmission at a low cost. These new wireless technologies shape the IoT ecosystem due to their wide applications. This study aims to review the various features and analyze the performances of the leading LPWANs, namely LoRa, SigFox, NB-IoT, and Weightless. Initially, precise descriptions of their underlying technologies and various applications were provided. Then, several challenges facing the LPWANs and potential solutions were outlined. Finally, the study analyzed their performance against several specifications, including frequency range, Bandwidth, Modulation, and so on. The outcome shows that these technologies are more efficient than the short and medium-range IoT technologies, particularly regarding power, range, and cost. The study’s findings are hoped to provide a guide and eliminate LPWAN technology selection issues.
Systematic analysis of composition and molecular mechanisms of action of the Vitex agnus-castus standardized extracts. Literature review
Authors: И. Ю. Торшин  , О. А. Громова  , О. А. Лиманова
Published: August 2022

Extracts of Vitex agnus-castus are used to regulate the menstrual cycle, in the treatment of premenstrual tension syndrome, hyperprolactinemia, and infertility. Vitex extracts component analysis showed the presence of such compounds as vitexin, rotundifuran, kastitsin, artemetin and some phytoestrogens. Extracts components are characterized with antiinflammatory, antiproliferative, antioxidant, antimicrobial (particularly antifungal), vasoprotective and analgesic effects. The role of the extracts components in modulation of opioid and dopamine receptors has been described. The paper also reviews estrogen modulating and anti-hyperprolactinemic properties of Vitex extracts
Algumas considerações sobre os movimentos dos corpos na antiguidade e na Idade Média: a teoria do ímpeto e a inércia
Authors: Campos Alexandre
Published: August 2022

O artigo apresenta algumas considerações presentes nas discussões acerca da natureza do movimento entre os séculos XIV e XVII. Para isso, adotarei as perspectivas presentes nas argumentações de pensadores como Aristóteles, Buridan, Oresme e Galileu. A teoria do impetus, de Buridan e Oresme, pavimentou o caminho para as argumentações galileanas, na medida em que possibilitou explicar a persistência do movimento após a perda de contato entre aquilo que dava origem a ele. Ou seja, a teoria do impetus permitiu que se explicasse a continuidade do movimento em função de uma propriedade intrínseca do objeto (quantidade de matéria e impetuosidade do agente movente no momento do lançamento) em contraposição à necessidade de um motor em contato permanente com o movido (antiperístase aristotélica). Essa perspectiva permitiu que se unificassem numa só teoria os movimentos terrestres e os movimentos celestes. Galileu parece se valer de alguns aspectos da construção lógica dessas argumentações. O trabalho não tem a pretensão de apresentar e discutir historicamente como se deu cada um desses aspectos, detalhes locais, nem seus contextos sociais. Ao contrário, trata-se de uma quase descrição de suas ideias centrais.Some considerations about motion of bodies at Antiquity and at Middle Age: the impetus’ theory and the inertiaThe article shows some considerations present in the discussions about the nature of movement between the 14th and 17th centuries. For this, the perspectives present in the arguments of thinkers such as Aristotle, Buridan, Oresme and Galileo will be adopted. The impetus theory of Buridan and Oresme paved the way for Galilean arguments, insofar as they made it possible to explain the persistence of movement after the loss of contact between what gave rise to it. In other words, the theory of impetus made it possible to explain the continuity of movement as a function of an intrinsic property of the object (amount of matter and impetuosity of the moving agent at the moment of launch) as opposed to the need for a motor in permanent contact with the moved (Aristotelian antiperstasis). This perspective allowed the unification of terrestrial and celestial movements in a single theory. Galileo seems to make use of some aspects of the logical construction of these arguments. The work does not intend to present and discuss historically how each of these aspects took place, local details, or their social contexts. On the contrary, it is a quasi-description of its central ideas.Keywords: Impetus Theory; Inertia; Mechanics; Galileo.
16-bit dissensus: post-retro aesthetics, hauntology, and the emergency in video games
Authors: Dolan Patrick R.
Published: August 2022

Santiago Zabala reveals a crisis in modern society that perceives a world dominated by oppressive neoliberal ideology as acceptable and unproblematic. He claims that today’s greatest emergency is that we fail to notice other emergencies in society. To break out of this state, we need an aesthetic force to shock individuals into a new awareness. Unfortunately, while many social and global issues have recently come to widespread attention, the emergency still prevails in many forms of media. For example, the emergency in AAA video games appears in their continual push for higher resolution graphics, hyper-detail, verisimilitude, and intricate gameplay, perpetuating a hegemonic ideology. Exploitative labor practices, lack of representation beyond hetero-sexual, cis-gendered and neurotypical, and capitalist ideals are perpetuated in popular games in service of a hyper-real, high-fidelity aesthetic. One force that combats this emergency is pixel graphics and simplified gameplay, or post-retro aesthetics. While tied to the past, these aesthetics are not nostalgic but transgressively hauntological. To explore this claim, I discuss Dys4ia and Undertale as key post-retro games and reach beyond commercial indie gaming to point to hauntological work being done through DIY game making platformers such as Bitsy.
Clima escolar y factores asociados: modelo predictivo de ecuaciones estructurales
Authors: Cuadra-Martínez David , Pérez-Zapata Daniel , Sandoval-Díaz José , Rubio-González Juan
Published: August 2022

El objetivo de este trabajo fue proponer un modelo de ecuaciones latentes que estructure la relación entre engagement académico, schadenfreude y comportamiento prosocial sobre el clima escolar. Se trabajó con una metodología cuantitativa en base a un diseño transversal-transeccional y un muestreo no probabilístico de 437 estudiantes de educación secundaria en Chile. Se realizó análisis factorial y de confiabilidad de los instrumentos aplicados, correlaciones de Pearson y ecuaciones estructurales. Después de ajustar dos modelos para los datos y contrastarlos con la literatura teórica, se encontró que el engagement académico afecta a todas las variables. El engagement académico afecta de manera positiva, directa e indirectamente al clima escolar. Un aumento del engagement académico también disminuye los niveles de schadenfreude y provoca un incremento de los niveles del comportamiento prosocial. Se discute sobre las implicancias de estos hallazgos, sus limitaciones y se proponen sugerencias que podrían orientar el estudio e intervención del clima escolar.
Modelo de predicción de la demencia en adultos mayores de 60 años
Authors: Santacruz Ortega María del Pilar , Cobo Charry María Fernanda , Avendaño-Prieto Bertha Lucía , Mejía Arango Silvia
Published: August 2022

Con el objetivo de determinar el aporte de las variables sociodemográficas, psicosociales y de salud, a un modelo de predicción de la demencia en población adulta mayor, se realizó un análisis secundario con los datos del estudio de “Salud, Bienestar y Envejecimiento. Bogotá, 2012”, con 2000 hombres y mujeres mayores de 60 años de áreas urbanas y rurales de Bogotá. Para seleccionar la muestra, se realizó un muestreo probabilístico, polietápico, de conglomerados y estratificado, basado en el censo nacional del 2005. Se utilizó el cuestionario SABE adaptado para Colombia. De acuerdo al nivel de medición de cada variable y la distribución de los datos, se realizaron análisis univariados y bivariados, con la demencia como variable criterio y como predictoras las variables sociodemográficas, de salud; se incluyeron 30 variables. Se encontró que el 40.1% de la varianza de la demencia es explicada por la edad, nivel educativo y socioeconómico, hipertensión, accidente cerebrovascular, depresión, disfuncionalidad motora, fractura de cadera, salud comparada, víctima de atraco, consumo de alcohol, memoria, autorreporte de memoria y memoria comparada. Los hallazgos ofrecen un modelo estadístico que permite la detección de los factores de riesgo para la demencia y el análisis de los potencialmente modificables para su prevención.
Enciumar(-se), experiência feminina? dilemas narcísicos sob a ótica interseccional de gênero
Authors: Campos Guimarães Maisa , Zanello Valeska
Published: August 2022

Os ciúmes permeiam relações afetivas configurando-se como fenômeno subjetivo, relacional e sociocultural. Em uma leitura interseccional de gênero e raça, aponta-se o dispositivo amoroso como central na subjetivação das mulheres. Esta pesquisa qualitativa objetivou compreender como mulheres nomeiam, significam e lidam com o próprio ciúme e/ou com o de parceiros amorosos. Realizou-se entrevistas narrativas com 12 mulheres, em relacionamentos heteroafetivos, com queixas sobre ciúmes. Pela análise de conteúdo, as categorias foram organizadas entre ciúmes recebido (Ser a “escolhida”; Ciúme normal x anormal; Autores-ponsabilização delas e desresponsabilização deles) e sentido (“Risco” de serem abandonadas, Ciumenta: de insegura a louca? Rivalidade feminina acirrada por dilemas raciais e estéticos). Leituras interseccionais das emocionalidades revelaram como o ciúme interpela dilemas narcísicos gendrados e racializados.
Precarity, ungrievability, and thinking beyond the law: a framework for understanding the position of LGB individuals in South Africa
Authors: Westman Claire
Published: August 2022

Drawing primarily on the work of Judith Butler and Drucilla Cornell, this paper aims to provide a theoretical framework for understanding the position of sexual minorities in South Africa. This will be done particularly in light of the violence, discrimination, and marginalisation that is experienced by, predominantly, black gay, lesbian, and bisexual individuals from poorer South African communities. In so doing, the paper also explores how the marginalisation of and violence against LGB individuals play an important role in national identity development and the upholding of a hetero-patriarchal social order. The goal is thus to create an understanding of why, despite legal and constitutional rights, LGB individuals continue to be marginalised, violated, and discriminated against in their everyday lived experiences, and further, why, because of this socio-symbolic positioning, the law cannot necessarily guarantee these rights or protections.
Manajemen Pembelajaran Fiqih dengan Media Gambar di Madrasah Aliyah Kulliyatul Mu’allimin Al-Islamiyah Assalam Desa Bahoro Kecamatan Bangilan Tuban
Authors: Azis Muhammad Miftahul
Published: August 2022

penelitian ini membahas tentang : 1. apa yang direncanakan dalam pembelajaran dengan  media gambar dengan di Madrasah Aliyah Kulliyatul Mu'allimin Al-Islamiyah ASSALAM 2. Bagaimana pengorganisasian pemebelajaran fiqih dengan media gambar dengan di Madrasah Aliyah Kulliyatul Mu'allimin Al-Islamiyah ASSALAM 3. Bagaimana pegimplementasian pembelajaran fiqih media gambar dengan di Madrasah Aliyah Kulliyatul Mu'allimin Al-Islamiyah ASSALAM. Fokus penelitian ini terletak pada proses dan hasil penggunaan media pembelajaran yang diterapkan dalam kajian fiqih pada materi qurban. Hal ini disebabkan karena pose-pose pembelajaran fiqh yang diterapkan di madrasah ASSALAM belum optimal karena monoton dan kurangnya media yang dapat mendukung pemahaman siswa. Peneliti dalam prosesnya menitikberatkan pada tahapan penerapan media gambar pada pemahaman siswa tentang materi pengorbanan, korelasi media gambar terhadap pemahaman siswa dan prestasi belajar siswa dengan penggunaan media gambar. Pendekatan dalam penelitian ini menggunakan deskriptif kualitatif. pendekatan desain studi kasus dengan tujuan untuk menjelaskan fenomena yang terjadi secara objektif di lapangan. Sedangkan pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi.
Manajemen Pembelajaran Kitab Kuning di Sekolah Tinggi Kitab Kuning
Authors: Aulia Ina , Antariksa Walid Fajar
Published: August 2022

Pesantren is an educational institution in Indonesia that uses the classical book as a reference for learning. The classical book contains the contents of various sciences that guide Muslims in their live. Islamic boarding schools are currently facing the modernization of Islamic education. One of the pesantren that follows the development of science and the progress of the times is the An-Nur 3 Islamic Boarding School. This Islamic boarding school provides primary, secondary, and high school education and has an advanced level of learning, a special program, namely the College of Classical Book (STIKK). This study aims to describe how the learning management of the classical book in STIKK An-Nur 3, from Lesson planning, Learning implementation, and Learning evaluation. This study uses a qualitative approach. The research data were taken by interview, observation, and documentation techniques. The results showed that this STIKK is the program of AN-Nur 3, which aims to teach the essence of the classical book more deeply than the previous madrasah levels. In learning the Classical book at STIKK, there is a planning, implementation, and evaluation process that supports learning activities to run effectively and efficiently. What distinguishes it from other educational programs is that students at STIKK, besides studying the yellow book, also study in a university that has an agreement with STIKK.
INFLUENCE OF PRODUCTIVE STRUGGLE IN MATHEMATICS TO THE 21st CENTURY LEARNERS
Authors:   Secondary School Teacher III, Department of Education, City Schools Division of Tandag Tandag National Science High School, City of Tandag, Philippines, Laro Salazar Christian
Published: August 2022

This study dealt with finding the influence of productive struggle in Mathematics to 21st-century learners. Furthermore, it aimed to determine the problems encountered by the learners when they are exposed to activities that promote productive struggle. This study utilized the quasi-experimental pre-test post-test design. It has been found out that productive struggle is extremely influential to 21st-century learners for it has helped them to be motivated in managing to improve their skills in mathematics. Furthermore, it was found out in this study that the problem that most of the learners encounter when they are in productive struggle is the fact that they cannot finish the activity within a given amount of time. Findings revealed that there is a significant difference in the achievement test scores of the learners with and without activities that promotes productive struggle. In addition, it has also been found out that there is a significant interaction between the achievement test scores of the learners in the experimental group if they will be classified according to their mental capacity. Therefore, independent learning using activities that promote productive struggle is found to be more effective than the conventional lecture method.
Corona Virus Disease 19 On Islamic Theological Reflection
Authors: Rizky HK Muhammad
Published: August 2022

The Covid 19 pandemic has changed the entire structure of human life. From economic problems, social relations, to the most intimate parts of human life; Faith. Aqida as a foundation of religious belief in Islam, shaken by various theoretical problems, to answer questions; How does Islam from a theological reflection facing this pandemic situation? Through this article, the author demands to present a theological reflection in the face of the COVID-19 pandemic. By recollecting the thoughts of Islamic classical theology, with various ideologies and schools of thought in Islam as secondary sources, with the humanist theology’s approach this article seeks to provide theological perspective and reflection, to nurture religious beliefs, and provide theological explanations for the pandemic situation related to the Muslim community.
Kritik bn Al-‘Arabi Terhadap Aqidah Syiah Dalam Kitab al-'Awasim wa al-Qawasim
Authors: Iqbal Muhammad
Published: August 2022

This article aims to analyze the methods used by Ibn ‘Arabi al-Ma’rifi in order to reject all the theological concepts of Shia, the second Islamic sect after Sunni based on his book al-‘Awasim wa al-Qawasim. This article used qualitative methods based on library research by reading the book of the author and analyse the methodological point of the author in his critics. The life of Imam Abu Bakr Ibn al-Arabi al-Ma’afari - may God have mercy on him - was full of knowledge since his childhood, as he grew up in a house of knowledge and righteousness, and his journey to the countries of the Orient had the greatest impact on his brilliance in the types of sciences and knowledge. With the breadth of his knowledge and the length of his sale, he is an investigator and an auditor. He is a Sunni scholar keen on the Book and the Sunnah. Imam Abu Bakr bin al-Arabi al-Ma’afari, may God have mercy on him, followed the method of Ahl al-Sunnah wal-Jamaa’ah in criticizing the beliefs of the Shiites. His clear position in responding to Ali's succession, may God be pleased with him, in the belief of the Shiites, and his eminent response, may God have mercy on him, to their suspicions about the Companions.
Relasi Sosial Umat Kong Hu Cu Di Kawasan Simpang Lima Ampenan Kota Mataram
Authors: Azizah Lutfatul , Yuhana Yuhana
Published: August 2022

This article aims to looks at the pattern of the relations built by the Confucians community and the practices of peace that are applied.  As a minority religious group, The Confucians community in Ampenan  cannot be separated from their efforts to survive with the adaptation strategies that are carried out. The intended adaptation strategy is the pattern of relationships that are built. Using a qualitative research method where the data collection process uses the method of observation, interviews and documentation. With the help of AGIL theory, this article also finds that the adaptation made by the Confucians is an merely an adaptation to the economic activity’s as an primary aspect. The practice of peace that is applied is also with the economic aspect. This partially refutes AGIL's theoretical framework by looking at Goal Attainment, the integration and built latency do not reach their ideal point. The main  reason why the Confucians chose the economic aspect over the religious aspect was to evade the unsuccesful story between Hindu-Muslims which failed to build the relationship pattern through the pattern of marriage relation.s The effective pattern of relations in maintaining the harmony of the people in the Simpang Lima Ampenan Mataram area is through the economical aspect
Keadilan Dan Hak Asasi Dalam Terang Fajar Filsafat Islam
Authors: Adabiyah Radiyatun
Published: August 2022

In order to seek the nature of human rights in Islamic philosophy, it will not be able to understood until clarify the overall Islamic concept of nature, humans and life. As it is also known that the essence of justice cannot be separated from the relationship that occurs between the Creator and creatures. Justice also becomes very important in law, because it is subjective and individual. Justice as a value to create an ideal relationship between humans, as a manifestation of their rights. In this case, justice is the basis that is committed to delivering humans to a just, prosperous and happy life. As it is known that the practice of law in the western sense is really in accordance with the special attention of some experts in Islamic law. The meaning of Islamic philosophy itself cannot be separated from the Greek teachings which are collaborated with the contents of the explanations/teachings in Islam. So the discussion on human rights will not be separated from the discussion of Epistemology, Ontology and Axiology. It is well known that philosophy itself will not be separated from logic, because the context of the discussion of philosophy will continue to change as a civilization develops. If we mention about Islamic philosophy, we will know how the nature of justice is seen from the perspective of logic that is shaded by the Islamic side. How that sense works well in determining an acceptable justice for the welfare of human rights. It has also been stated that humans are intelligent animals, so humans are different from other animals in general. Intellect is a benchmark for the perfection of a human action in deciding something. Justice for human rights in the view of Islamic philosophy is justice for human rights which is applied in accordance with mature thinking and cannot be separated from the teachings of the Qur'an and Sunnah.
A articulação como elemento expressivo na performance ao violão: um estudo a partir da análise de tratados clássicos e sua aplicação na sonata Eroica de Mauro Giuliani
Authors: Afonso Felipe dos Anjos , Scarduelli Fábio
Published: August 2022

O presente trabalho trata do estudo da articulação como elemento expressivo ao violão. Ao analisarmos métodos de referência pedagógica da escola clássico-romântica, observou-se a ausência de detalhes acerca deste assunto. Entretanto, tratadistas da mesma época de outros instrumentos apresentam alternativas para a utilização de diferentes articulações. Sendo assim, buscamos analisar padrões de articulação presentes nos tratados de C. Ph. E. Bach, L. Mozart e J. Quantz (tecla, arco e sopro) e utilizá-los como ferramenta para elaboração de articulações para os Estudos 1 e 9 Op. 60 de Matteo Carcassi; Estudo 8, de Dionísio Aguado; Estudo 4 Op. 139 e Sonata Eroica Op. 150, de Mauro Giuliani. A metodologia utilizada está dividida em três etapas: 1) definição de conceitos relacionados à performance; 2) análise de tratados; 3) aplicação prática. Observamos que, em geral, as obras escritas para violão oferecem poucas informações relacionadas à articulação quando comparadas a obras de outros instrumentos. Portanto, o acréscimo de ideias de articulação, provenientes de diferentes tratados, promoveu variações significativas na expressividade das peças selecionadas.
Drug and apoptosis resistance in cancer stem cells (CSCs): A puzzle with many pieces
Authors: Safa Ahmad R.
Published: August 2022

Resistance to anti-cancer agents and apoptosis results in cancer relapse and is associated with cancer mortality. Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anti-cancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal (EMT) progression. CSCs represent a heterogeneous tumor cell population and lack specific cellular targets, which makes it a great challenge to target and eradicate them. Similarly, their close relationship with the tumor microenvironment (TME) creates greater complexity in developing novel treatment strategies targeting CSCs. Several mechanisms participate in the drug and apoptosis resistance phenotype in CSCs in various cancers. These include enhanced expression of ATP-binding cassette (ABC) membrane transporters, activation of various cytoprotective and survival signaling pathways, dysregulation of stemness signaling pathways, aberrant DNA repair mechanisms, increased quiescence, autophagy, increased immune evasion, deficiency of mitochondrial-mediated apoptosis, upregulation of anti-apoptotic proteins including c-FLIP (cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein), Bcl-2 family members, inhibitors of apoptosis proteins (IAPs), and PI3K/AKT signaling. Studying such mechanisms not only provides mechanistic insights into these cells that are unresponsive to drugs, but may lead to the development of targeted and effective therapeutics to eradicate CSCs. Several studies have identified promising strategies to target CSCs. These emerging strategies may help target CSC-associated drug resistance and metastasis in clinical settings. This article will review the CSCs drug and apoptosis resistance mechanisms and how to target CSCs.
New insights for drug resistance in metastatic castration-resistant prostate cancer
Authors: Kushwaha Prem Prakash , Gupta Sanjay
Published: August 2022

Prostate cancer is the most common cancer and is the second leading cause of cancer-related deaths among men in the United States. Androgen deprivation therapy (ADT) is the standard treatment for advanced-stage prostate cancer; however, this treatment eventually fails, leading to an incurable disease subtype known as metastatic castration-resistant prostate cancer (mCRPC). There are several molecular mechanisms that facilitate the development of mCRPC engaging androgen receptor (AR) growth axis, including AR amplification, gain of function AR mutations, and AR splice variants that are constitutively active and are a foremost factor for mCRPC development. AR-independent mechanisms with exceptionally low or absent AR expression found in cancer cells suppress ADT effectiveness and contribute to aggressive variants, including neuroendocrine differentiation. Several other AR regulatory factors such as epigenetic modification(s), and DNA damage response have been reported during post-ADT exposure and play a crucial role in mCRPC development. Therefore, targeting prostate cancer cells before their progression to mCRPC would improve patient outcomes. This special issue in “Cancer Drug Resistance” focuses on understanding the mechanism(s) and development of mCRPC resistance. This special issue also highlights the therapeutic strategies to combat against resistant subtype. This issue comprehensively reviews the mCRPC and delivers the update in the forum of mCRPC resistance development.
Advances in second-generation high-temperature superconducting tapes and their applications in high-field magnets
Authors: Wang Kai , Dong Hao , Huang Daxing , Shang Hongjing , Xie Bowei , Zou Qi , Zhang Lin , Feng Changping , Gu Hongwei , Ding Fazhu
Published: August 2022

Second-generation high-temperature superconducting (2G-HTS) tapes based on REBa2Cu3O7-x (REBCO, RE: rare earth) materials enable the energy-efficient and high-power-density delivery of electricity, thereby promoting the development of clean energy generation, conversion, transmission, and storage. To overcome the weak grain-boundary connection and poor mechanical properties of these superconductors, a thin-film technology for epitaxy and biaxial textures based on flexible substrates has been developed. In recent years, high-quality 2G-HTS tapes have been produced at the kilometer scale and used in superconducting demonstration projects. This review first summarizes the development of HTS materials and briefly expounds the properties of REBCO superconducting materials. Subsequently, the structural characteristics, preparation methods, and current research progress of 2G-HTS tapes are given. In addition, the applications of REBCO tapes in constructing high-field magnets are also briefly reviewed.
Reliable metal alloy contact for Mg3+δBi1.5Sb0.5 thermoelectric devices
Authors: Song Shaowei , Liang Zhongxin , Xu Congcong , Wang Yu , Shi Xin , Ren Wuyang , Ren Zhifeng
Published: August 2022

Proper contacts between thermoelectric (TE) materials and electrodes are critical for TE power generation or refrigeration. The Bi-rich n-type Zintl material Mg3+δBi2-xSbx exhibits very good TE performance near room temperature, which makes Mg3+δBi2-xSbx-based compounds highly promising candidates to replace the Bi2Te3-ySey alloys, but ideal contacts that can match their TE performance have not yet been well studied. Here we investigate different metal (Ni and Fe) and metal alloy (NiFe, NiCr, NiCrFe, and stainless steel) contacts on n-type Mg3+δBi1.5Sb0.5. It is first shown that the low Schottky barrier and narrow depletion region resulting from the band degeneracy and high carrier concentration of a heavily doped TE material are beneficial for the formation of a low-resistivity ohmic contact with a metal or a metal alloy. Most fully optimized TE materials can take advantage of this. Second, it is found that the NiFe/Mg3+δBi1.5Sb0.5 contact exhibits excellent thermal stability and the lowest ohmic contact resistivity among those studied after aging for over 2100 h, which is attributed to the formation of metallic NiMgBi between the NiFe and Mg3+δBi1.5Sb0.5 layers. As a buffer phase, NiMgBi can effectively prevent elemental diffusion without negatively affecting the electron transport. Benefiting from such low contact resistance, a Mg3+δBi1.5Sb0.5/Bi0.4Sb1.6Te3 unicouple exhibits competitive conversion efficiency, 6% with a 150 K temperature difference and a hot-side temperature of 448 K.
Future-proofing imperatives for remote online teaching, learning and student support in the context of pandemic change and beyond: A case for South African higher education transformation
Authors: D. van Staden , P. Naidoo
Published: August 2022

South Africa’s Plan for Higher Education identified equity and redress as key objectives guiding institutional transformation. This encompasses granting individuals fair opportunities to enter higher education and succeed therein. The COVID-19 pandemic which abruptly disrupted the 2020 academic year highlighted several challenges which have implications for student success. Academic continuity in the form of online learning was pursued by most higher education institutions. However, the remoteness of rural communities, which typifies the home environments for many South African students, threatened to exclude such students from online learning activities. The lack of access to digital devices as well as reliable internet connectivity in many of these communities impacted students’ ability to engage in online learning as well as access campus-based support services. The imposed lockdown therefore caused heightened anxiety and feelings of isolation from academic activities amongst the South African student population. Since access to on-campus support systems was no longer possible, student wellness and ongoing academic engagement was potentially compromised. Increasingly, the mental health cost of remote learning was becoming apparent, with higher education institutions compelled to rethink how student support services are delivered. In the absence of face-to-face support services during the hard lock-down period, the emergent need was to identify new ways of reaching out to displaced students who may be experiencing both academic and personal distress under conditions of daunting technological changes and virtual forms of engagement, social isolation, socio-economic disadvantage and psycho-social stressors. While blended learning and hybrid forms of holistic student support were accelerated by the advent of the Covid-19 pandemic, the blended approach has become an indelible reality of Higher Education that is here to stay. As such, reflections on how student support services at universities in South Africa have adapted and need to continuously evolve in the face of an uncertain world, is both timely and necessary if the goal of promoting equal access and success in Higher Education – for all - is to be fully realized.
Dance as a complementary pedagogic tool in architectural education
Authors: C. Daskalakos
Published: August 2022

Architectural education is complex as it requires the development of both objective and subjective knowledge. While explicit knowledge that meets the trends in universities to create value by preparing students for industry, are easier to include in a curriculum, implicit knowledge based on personal experience that facilitates flexibility and creativity is more challenging. An example in the training of future architects is highlighted by the tendency to rely heavily on the visual sense in relation to buildings, which tends to objectify them, thereby ignoring their experiential components. The move towards digital applications in design further alienates the designers from this experiential aspect, as the technology leads to disembodiment and hence the sensitivity to subjective aspects of design. Design of space is influenced subconsciously by habitual patterns of behaviour embedded culturally and autobiographically in body memory. Dance as a complementary pedagogic tool can develop understanding of self and the body, bringing such habitual patterns into awareness. In addition to creating awareness, dance offers the tools to explore alternatives, creating a new meaning and relationship to space thus aiding the design skills of students. A curriculum that includes the subjective and autobiographical aspects of the student reflects the educational theory of Currere proposed by William Pinar and a pedagogic approach that reflects the theories of Georgio Agamben’s “rhythm” and Alfred Whitehead’s “cycles in learning”.
A self-determination theoretical approach into survival strategies of on-campus and off-campus students from low-income families
Authors: F. Ravhuhali , L. Nendauni , T. D. Sikhwari , N. P. Lavhelani , N. G. Dama , T. Matodzi , T. Manyage
Published: August 2022

An enormous number of students from rural-based universities are drawn from provinces which are primarily regarded as rural provinces in South Africa, due to underdevelopment which is rhetorically blamed on the legacy of apartheid. Moreover, a vast number of these students are enrolled at universities as first generation and largely come from low-income families, characterised by elements of poverty. These students often experience literacy problems, mostly because of the type of high school they attended. Be that as it may, these students need to survive, hence, the need for this type of exploration, which sought to understand survival strategies of students from low -income families in a South African rural-based university. This study or article is solely rooted on Self-determination theory as the theoretical point of departure. Nevertheless, it also incorporates elements of Bandura’s Social cognitive theory as a supplementary theory. Following a qualitative research design, the population of the study comprised students from low-income families. Purposive and snowball sampling procedures were used to select students’ questionnaires with open-ended questions, whilst content analysis was used as a data analysis tool. The findings of the article exhibit several complexities and difficulties that students from low-income families endure such as lack of funds, materials and being exposed to crime. Students make use of financial aid schemes, peer support groups and university’s financial aid to survive. The article has implications for higher education institutions on how they can adopt a variety financial aid practices that could be tailored towards assisting on-campus and off-campus students from low-income families.
Program renewal: Re-evaluating teaching pedagogy in auditing
Authors: Sexton N. D. , R. Rudman
Published: August 2022

Accounting graduates are entering an uncertain, rapidly changing world that calls for the enhancement of the pedagogy to prepare them for their future world of work. Technical competence needs to be scaffolded with enabling (professional) competencies more than ever before and deep learning is required for students to apply principles in any context. With this in mind, the lecturers at a South African university disrupted (i.e., significantly changed) how a keystone topic in third-year auditing is taught; specifically by creating blended learning interventions for reflection, collaboration, communication, and ethical considerations not previously used in auditing education. This research presents the student perceptions about the appropriateness of these interventions.
DIAMOND OF THE DESERT: THE CASE OF QATAR’S 2022 FIFA WORLD CUP
Authors: Russo Eduardo , Figueira Ariane , Swart Kamilla , Mataruna-Dos-Santos Leonardo Jose
Published: August 2022

For the first time in the Arab world, the FIFA World Cup in Qatar 2022 was one of the main drivers for promoting important infrastructural changes in the country, as well as for transforming the image of Qatar in order to make the destination more attractive to foreign tourists. However, despite the great wealth from its Oil & Gas reserves, several social challenges that historically affect the country began to emerge due to greater coverage of the international media, threatening the expectations of positive legacies left on the country's image from the event. Given this context, the case puts the reader in the role of Ahmed Al-Nasr, then Chairman of the Qatar Supreme Committee for Delivery and Legacy, as he faces different pressures made by major international brands sponsoring the event who now see their image threatened by successive controversies that the country has been involved in and they are threatening to withdraw their support and investments. The case is indicated for undergraduate and graduate students of courses in the area of Tourism, Sport Management, and Business interested in discussing topics and concepts related to environmental, social, and governance (ESG) responsibility, management of mega events, international marketing, and country destination image.
DETERMINING REVISIT INTENTION: THE ROLE OF VIRTUAL REALITY EXPERIENCE, TRAVEL MOTIVATION, TRAVEL CONSTRAINT AND DESTINATION IMAGE
Authors: Perdana Kusumah Echo , Hurriyati Ratih , Disman Disman , Gaffar Vanessa
Published: August 2022

Purpose – The purpose of this study is to define and analyze the role of virtual reality experiences, travel motivation, travel constraints, and destination image on revisit intention. Design – Exploratory analysis to investigate whether destination image and revisit intention are influenced by virtual reality experience, travel motivation, and travel constraints. Methodology – The respondents in this study were Indonesian tourists who had already visited the destinations under study. The sampling method used was random sampling and the data analysis method used was structural equation modeling. Findings – The results show that destination image can mediate the influence of virtual reality experience on revisit intention. At the same time, travel motivation and travel constraints can have a direct positive influence on destination image. Originality of the research – This study demonstrates the critical significance of virtual reality in pandemic situations to help destinations improve their image and hence increase tourist arrivals, like as in Indonesia
THE ROLE OF TOURISM AND FDI IN THE ECONOMIC GROWTH OF EU11 COUNTRIES
Authors: Sokhanvar Amin
Published: August 2022

Purpose - Tourism and FDI have contributed to a large extent to Central and Eastern European economies in recent decades. This paper investigates how successfully these two engines of growth have been stimulating the growth of these economies. Design/methodology/approach - Using a Pooled Mean Group estimation, this study investigates the short- and long-term effects of variations in the GDP shares of tourism and foreign investments on the economic growth rate. Findings - The results suggest that while tourism expansion is more effective in the short run, FDI has a significant positive impact on economic growth only in the long run. Originality - A new aspect of the present study is a comparison of the magnitude of the impacts of the GDP shares of international tourism and foreign investments on the economic growth rate in both the short and long run in the case of Central and Eastern Europe. Practical implications - Considering the economic structure of these countries, policy action plans for inclusive growth are suggested.
Responses of Religions Outside of Islam toward the Ecological Crisis: A Literature Review
Authors: Farhan Lalu Pattimura , Hadisaputra Prosmala
Published: August 2022

This article is the result of an online-based literature review. This study formulates the following question: what are the responses of religions outside Islam in Indonesia regarding the ecological crisis? The primary data of this study are articles from scientific journals that focus on theo-ecology from the perspectives of Christianity, Hinduism, Buddhism, and Confucianism. The data were obtained through the Google Scholar and DOAJ pages. This study finds that first, Christianity responds to the ecological crisis by presenting the theo-ecological concept as part of the affirmation of faith in God. The teaching of environmental conservation is a way of glorifying all of God’s creations. Second, Hinduism responds to the ecological crisis through its five teachings, namely Rta, Yadnya, Danu Ktih, Rwa Bhineda, and Tri Hita Karana, including Parhyangan Pawongan and Weakening. Third, Buddhism responds to environmental conservation with its teachings that emphasize the importance of beauty (aesthetics), as found in the Dhammapada-Khuddhaka Nikāya. Fourth, Confucianism responds to the ecological crisis through moral teachings such as protecting the environment.
Pengembangan Aplikasi Pengelolaan Sampah Berbasis Android Studi Kasus Bank Sampah Desa Kalibagor
Authors: Fitriana Gita Fadila , Hashina Adinda , Tanjung Nia Annisa Ferani
Published: August 2022

Penumpukan sampah tercatat mencapai 625 juta liter dari jumlah penduduk pada tahun 2012 di Indonesia menurut Kementerian Lingkungan Hidup. Dari hal ini Bank Sampah menjadi sebuah solusi bagi pemerintah dalam penanggulangan pengelolaan sampah. Namun dalam berjalannya Bank Sampah, terdapat beberapa kendala yang dialami. Seperti yang dialami oleh bank sampah desa Kalibagor kecamatan Kalibagor Kabupaten Banyumas. Bank Sampah yang ada di desa Kalibagor ini sudah berjalan sejak oktober tahun 2020. Dalam menjalankan Bank Sampah ini KSM (Kelompok Swadaya Masyarakat) selaku petugas Bank Sampah mengalami kesulitan yaitu karena Bank Sampah masih melakukan pencatatan transaksi secara manual sehingga meningkatkan resiko kehilangan data. Maka dari itu diperlukan aplikasi yang dapat mencatat berbagai transaksi yang ada di Bank Sampah berbasis android. Dalam pengembangan aplikasi ini akan menggunakan metode Kanban. Hasil yang diperoleh dari pengembangan aplikasi ini adalah berhasil membangun aplikasi berbasis android menggunakan metode Kanban yang dapat mencatat berbagai transaksi di dalam Bank Sampah desa Kalibagor sehingga dapat membantu petugas KSM dalam pencatatan transaksi Bank Sampah. Selain itu hasil dari pengujian aplikasi yang melibatkan lima responden menujukan bahwa aplikasi dapat berjalan sesuai dengan harapan dengan hasil kelayakan 100% berhasil.