bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolic engineering of Escherichia coli to convert ethanol into L-tyrosine
Authors: LIANG Hong , ZHOU Kang
Published: September 2023

Utilizing ethanol derived from waste streams could establish shorter biosynthetic metabolic pathways to produce target metabolites, such as acetyl-CoA-derived chemicals. We have previously designed and constructed a two-step heterologous ethanol utilization pathway (EUP) in Escherichia coli that converts ethanol into acetyl-CoA derived compounds, including polyhydroxybutyrate (PHB) and prenol. In this study, we engineered E. coli to produce tyrosine efficiently by using ethanol as a major carbon source. Ethanol was converted into acetyl-CoA and then metabolized to generate biomass, provide energy, and produce tyrosine. The engineered strain produced 1.6 g/L tyrosine from 10 g/L ethanol. We hypothesized that the glyoxylate shunt was activated when ethanol was used as sole carbon source, and it was confirmed by transcriptome analysis. The key node gene aceA, encoding isocitrate lyase was upregulated 74-fold compared with the strain growing on glucose. To our knowledge, this is the first report of producing tyrosine from ethanol. The results support that ethanol has the potential to become a renewable feedstock to produce structurally complex chemicals.
Some new invariant sum tests and MAD tests for the assessment of Benford's Law
Authors: Kössler Wolfgang , Lenz Hans-J. , Wang Xing David
Published: September 2023

The Benford Law is used world-wide for detecting non-conformance or data fraud of numerical data. It says that the significand of a data set from a universe is not uniformly, but logarithmically distributed. Especially, the first non-zero digit D1 is One with probability P (D1 = 1) = log10 2 ≈ 0.3. There are several tests available for testing Benford, the best known are Pearson’s χ2 -test, the Kolmogorov-Smirnov test and the MAD-test suggested by Nigrini (2012). The latter test was enhanced to significance tests in K¨ossler, Lenz and Wang (2021) and in Cerqueti and Lupi (2021). In the present paper we propose some tests, three of the four invariant sum tests are new and they are motivated by the sum invariance property of the Benford Law. Two distance measures are investigated, Euclidean and Mahalanobis distance of the standardized sums to the orign. We use the significands corresponding to the first significant digit as well as the second significant digit, respectively. Moreover, we suggest inproved versions of the MAD-test and obtain critical values that are independent from the sample size. For illustration the tests are applied to specifically selected data sets where prior knowledge is available about being or not being Benford. Furthermore we discuss the role of truncation of distributions.
Demystifying CNN with Mathematical Insights: A Prelude with Application to an AI-based Sustainable Solution for Diabetic Retinopathy Diagnosis
Authors: Ali Amjad , Kazmi Syeda Zahra , Shahzadi Gullnaz , Rashid Muneeb , Ahsan Muhammad Umer
Published: September 2023

Convolutional Neural Networks (CNNs), as a computational framework for deep learning, have gained preference over traditional machine learning techniques and simple, fully- connected neural networks due to their remarkable performance for AI applications related to images and videos, in general, computer vision. Recent advancements in CNN architectures pave the way for significant contributions across various application domains, including disease diagnosis, object detection, and image classification systems. This article elaborates on the fundamental process of CNN with mathematical insights. It provides a brief overview of the mathematical and computational intricacies that underpin CNNs. It presents streamlined derivations of key components, focusing on the pivotal mechanism of the backpropagation. A pseudo-code of the generic algorithm for CNN is presented both in component form and vectorized form, alongside an exhaustive explanation of the relevant data structures to foster comprehensive understanding. The article includes an application of classifying retinal images for diagnosing diabetic retinopathy (DR). Having started the discussion about implementation from scratch, the article sheds light on transfer learning using pre-trained models for sustained efficiency. For this, performance gains are demonstrated using state-of-the-art CNN architecture for the DR classification. This way, the article aims to equip learners, researchers, and practitioners with mathematical insights into the working of CNN for proper comprehension and stepping towards efficient model development for sustainable advancements, especially for disease diagnosis. The understanding and expertise related to CNN would add to the development of large-scale and sustainable solutions based on AI in the health sector, supporting the United Nations’ agenda 2030 for sustainability.
ACM Classification Codes (ccs98): I.2.6, I.5.1, K.3.2. MSC Codes (2020): 68T07, 68T45, 92B20
Generalized group inverse in Banach *-algebras
Authors: Chen Huanyin , Sheibani Marjan
Published: September 2023

In this paper, we introduce the notion of the generalized group inverse in a *-Banach algebra.
This is a natural generalization of weak group inverse for a complex matrix and bounded linear operator over a Hilbert space. We present polar-like property for the generalized group inverse and characterize it by the generalized Drazin inverse. Furthermore, the relations between generalized group inverse and generalized core-EP inverse are investigated.
2020 Mathematics Subject Classification. 15A09, 16U90, 46H05.
3D analyses reveal T cells with activated nuclear features in T-cell/histiocyte-rich large B-cell lymphoma
Authors:   , Sadeghi Shoreh Deli Aresu
Published: September 2023

The Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) as well as the T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) are rare types of malignant lymphomas. Both NLPHL and THRLBCL are frequently observed in middle-aged men with THRLBCL presenting frequently with an advanced Ann-Arbor stage with B-symptoms and associated with more aggressive courses.3 However, due to the limited number of tumor cells in the tissue of both NLPHL and THRLBCL, limited numbers of studies have been conducted on these lymphomas and current results are mainly based on general molecular genetic studies. In order to obtain a better understanding for these disease forms as well as possible changes in their nuclear and cytoplasmatic sizes, the following study relied on the comparison of the different NLPHL forms and THRLBCL in terms of nuclear size and nuclear volume. This was carried out using both 2D and 3D analysis. During the 2D analysis of nuclear size and nuclear volume no significant differences could be presented between those groups. However, the 3D analysis of NLPHL and THRLBCL pointed out a slightly enlarged nuclear volume in THRLBCL. Furthermore, the analysis indicated a significantly increased cytoplasmatic size of THRLBCL compared to NLPHL forms. Nevertheless, differences occurred not only between the tumor cells of both disease forms, but also the T cells presented a larger nuclear volume in THRLBCL. B cells, which were considered as the control group, did not demonstrate any significant differences between the different groups. The presented results suggest an increased activity of T cells in THRLBCL, which is most likely to be interpreted as a response against the surrounding tumor cells and probably limits the proliferation of the tumor cells. Based on these results, the importance of 3D analysis is also evident due to the fact that it is clearly superior to 2D analysis. For a better understanding of both disease forms, it is therefore recommended to use the 3D technique in combination with molecular genetic analysis in future research.
War Through the Prism of International Law in Carl Schmitt's Political and Legal Teaching
Authors:   Russian State University for the Humanities, Antonov B. A.
Published: September 2023

The article is devoted to the political and legal analysis of Carl Schmitt’s (1888 – 1985) conception of war. Not once did Schmitt appealed to the topic of war arguing that it might be inevitable due to the specification of political reality (according to Schmitt – the concept of the political) characterized by the division into friends and enemies and constant confrontation between them. The author presents a brief genesis of Schmitt’s predecessors’ views on war (from Antiquity to Modernity), gives evidence to the regular transit from one type of war to another (from discriminational to limited and reverse) and on the basis of Schmitt’s teaching systematizes wars according to a number of grounds (legality / acceptability, attitude to a foe and theatre (locus) of military actions). Taking this into consideration, according to Schmitt it is necessary to reconstruct an international-legal order aimed at introducing into it such limitations that could prevent a military conflict from growing into a total war. Schmitt believed that such reconstruction would be possible due to “the reign of relative human reason” rather than to the rule of people (interpreted as international law nowadays). According to Schmitt, such reign could dominate if combatants followed the rules of war fighting rather than under the influence of international organizations. Schmitt allowed the possibility of warfare limitation (by law) in case of waging a duel war only as the latter obtains a limited interstate (European) character and is considered by Schmitt as the greatest achievement of European civilization.
Urban Space for Indonesian Women: Ambiguity in Nanti Kita Cerita Tentang Hari Ini (2019) Web Series
Authors:   Gadjah Mada University, Indonesia, Chusna Aidatul , Irawanto Budi , Arymami Dian
Published: September 2023

The depiction of Indonesian women’s experiences in urban spaces has been little discussed. Do urban spaces provide equal opportunities and access for Indonesian women and men? This paper tries to answer this question. It investigates how Indonesian women experience urban spaces as represented in an Indonesian web series entitled Nanti Kita Cerita Tentang Hari Ini (2019). The paper uses the multimodal analysis method. The result of the analysis shows that there is a discrepancy in the portrayal of the female protagonist and of the urban spaces that she experiences. The ambiguity is seen in the depiction of an urban woman who is empowered, but on the other hand, has limited rights in urban spaces. In particular, the female protagonist is portrayed as an independent urban woman who can make her own choices for her future. The depiction is in line with the idealization of a modern woman, which Indonesian women have long dreamt of. However, the female protagonist does not fully enjoy this freedom and independence as there is still gender stratification that regards women as being inferior to men. It is seen in the spaces that she experiences. The patriarchal system that has long dominated Indonesian society confines women’s mobility and existence in the public space.
A Saga of Cosmopolitan Friendship in Time of the Breaking of Nations: A Study of Ali Smith’s Autumn
Authors:   Department of English, Raja Rammohun Roy Mahavidyalaya, Nangulpara, Hooghly, West Bengal, India, Chowdhury Mousumi
Published: September 2023

Brexit, Britain’s exit from the supranational polity of the European Union has unsettled the vision of European unity. Rather than nourishing an “and/ both” cosmopolitan view even in the limited context of continental relationship, Britain inculcates an “either/ or” jingoistic nationalism fed on Euroscepticism. English literature has a long tradition of invoking political issues and Brexit has inaugurated a new sub-genre, ‘BrexLit’. The paper seeks to attempt a detailed study of Scottish writer Ali Smith’s novel Autumn (2016), designated by The New York Times as “the first great Brexit novel”. The first of the seasonal quartet, this novel was shortlisted for the Man Booker Prize 2017 and bagged the 2016 Baileys Women’s Prize for Fiction. Embedded in the Brexit Britain, the novel raises questions of citizenship, particularly in relation to immigration, and mirrors the loss of cultural conviviality. The paper discusses anti-immigrant toxicity, the upsurge of nostalgic appetite for national heritage, and the territorial social ontology of the contemporary English national outlook. The paper studies, in the context of the narrative, how the media resorts to post-truth politics and right-wing nationalistic propaganda in media resulting in the death of democracy and the end of dialogue. The paper explores how the novel advocates an inclusive, realistic cosmopolitanism through Elisabeth-Daniel friendship.
Nanosuspension: A Formulation Technology for Tackling the Poor Aqueous Solubility and Bioavailability of Poorly Soluble Drugs
Authors: Elsebay Mohamed T. , Eissa Noura G. , Balata Gehan F. , Kamal Mohammad Amjad , Elnahas Hanan M.
Published: September 2023

The poor water solubility of numerous novel drug candidates presents significant challenges, particularly in terms of oral administration. This limitation can result in various undesirable clinical implications, such as inter-patient variability, poor bioavailability, difficulties in achieving a safe therapeutic index, increased costs, and potential risks of toxicity or inefficacy. Biopharmaceutics Classification System (BCS) class II drugs face particular hurdles due to their limited solubility in the aqueous media of the gastrointestinal tract. In such cases, parenteral administration is often employed as an alternative strategy. To address these challenges, nanosuspension techniques offer a promising solution for enhancing drug solubility and overcoming oral delivery obstacles. This technique has the potential to bridge the gap between drug discovery and preclinical use by resolving problematic solubility. This literature review has delved into contemporary nanosuspension preparation technologies and the incorporation of stabilizing ingredients within the formulation. Furthermore, the manuscript explores nanosuspension strategies for both oral and parenteral/other delivery routes, and separate discussions have been presented to establish a suitable flow that addresses the challenges and strategies relevant to each administration method.
Covalent Binding of Fullerene С60 to Strained Polycyclic Hydrocarbons: Promising
Organic Field-effect Transistors Based on them
Authors: Akhmetov Arslan R. , Aminov Rishat I. , Sadretdinov Zarema R. , Salikhov Renat B. , Mullagaliev Ilnur N. , Salikhov Timur R.
Published: September 2023

Hybrid molecules based on fullerene С60 and strained polycyclic hydrocarbons were synthesized for the
first time using the Bingel–Hirsch reaction. The films of fullerene derivatives were deposited by centrifugation. The
synthesized hybrid fullerene С60derivatives containing one strained polycyclic hydrocarbon moiety showed better
charge carrier mobility than the fullerene derivatives containing two polycyclic hydrocarbon moieties. Apart from
current–voltage characteristics, the morphology of the prepared hybrid compounds was studied. The best current–
voltage characteristics were found for films with lower roughness. The fullerene С60 adducts containing strained
polycyclic hydrocarbon moieties were used to fabricate organic field effect transistors (OFETs) with high-quality
films; owing to this, the manufacturing process is compatible with modern printed organic electronics.
WITHDRAWN: Synthesis and Anticancer Activity of Newly Substituted 1,3,4-thiadiazole Derivatives: A Novel Class of Anticancer Agents
Authors: Chauhan Suman B. , More Uttam A. , Noolvi Malleshappa N.
Published: September 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Advancements in Autologous Stem Cell Transplantation for Parkinson’s Disease
Authors: Shi Jia-Xin , Zhang Ke-Zhong
Published: September 2023

:

Parkinson's disease (PD) is a progressive neurodegenerative disease marked by comparatively
focal dopaminergic neuron degeneration in the substantia nigra of the midbrain and dopamine loss in the
striatum, which causes motor and non-motor symptoms. Currently, pharmacological therapy and deep
brain stimulation(DBS) are the primary treatment modalities for PD in clinical practice. While these approaches
offer temporary symptom control, they do not address the underlying neurodegenerative process,
and complications often arise. Stem cell replacement therapy is anticipated to prevent further progression
of the disease due to its regenerative capacity, and considering the cost of immunosuppression
and the potential immune dysfunctions, autologous stem cell transplantation holds promise as a significant
method against allogeneic one to treat Parkinson's disease. In this review, the safety concerns surrounding
tumorigenicity and complications associated with transplantation are discussed, along with
methods utilized to evaluate the efficacy of such procedures. Subsequently, we summarize the preclinical
and clinical studies involving autologous stem cell transplantation for PD, and finally talk about the benefits
of autologous stem cell transplantation against allogeneic transplants.
An Update on Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria
Authors: Miniello Andrea , Casella Rossella , Loverre Teresa , Aloia Dario , Di Bona Danilo , Nettis Eustachio
Published: September 2023

Background:

Hypersensitivity reactions to non-steroidal anti-inflammatory drugs
(HR-NSAIDs) are common adverse events related to the widespread use of over-the-counter
NSAIDs for the treatment of a variety of inflammatory conditions. Urticaria is the most commonly
reported immediate cutaneous clinical sign of HR-NSAIDs, but it can be a manifestation
of pathophysiologically different clinical entities that require different therapeutic strategies. The
aim of this study is to ease the identification of the correct phenotype of HR-NSAIDs in patients
reporting urticaria associated with the intake of NSAIDs and provide updated information about
their diagnosis and management.

Methods:

The study is a narrative review conducted by collecting the most relevant and up-todate
data related to the classification, pathophysiology, severity, and prognosis of NSAID hypersensitivity
reactions. PubMed and Embase scientific databases were used as search engines to select
relevant articles.

Results:

Patients developing HR-NSAIDs can be divided into two categories: selective responders
(SR), who develop reactions after the administration of a single specific NSAID due to an
underlying IgE or T-cell mediated hypersensitivity mechanism, or cross-intolerant (CI), who develop
reactions to more than one chemically unrelated NSAIDs due to abnormalities in the biochemical
pathways related with prostaglandin metabolism, independently from an underlying
immunological mechanism. Five major different categories of HR-NSAIDs have been identified:
NSAIDs-exacerbated cutaneous disease (NECD), NSAIDs-induced urticaria/angioedema
with/without respiratory and systemic symptoms of anaphylaxis (NIUAA), and NSAIDsexacerbated
respiratory disease (NERD), which are developed by CI patients, and single
NSAIDs-induced urticaria, angioedema and/ or anaphylaxis (SNIUAA) and single NSAIDsinduced
delayed hypersensitivity reactions (SNIDHR), which are developed by CI patients. In vivo
and in vitro diagnostic tests have rarely been shown to be reliable in all these entities and
therefore are not routinely used in clinical practice. The management in SR patients consists of
strict avoidance of the culprit drug, while for cross-intolerance reactions oral tolerance tests with
safe alternative drugs (e.g. weak COX-1 inhibitors or selective COX-2 inhibitors) can be performed.

Conclusion:

HR-NSAIDs are being observed with increasing frequency, however, the pathogenesis
behind some NSAIDS-associated clinical entities is still unclear. Diagnosis is mostly
based on a thorough clinical history and confirmed by a drug challenge test. Clinical
management is based on strict avoidance and use of alternative tolerated medications. Overall, all
therapeutic decisions depend on the correct identification of the type of reaction the patient
experienced.
Knowledge Mapping of Human Activity Recognition Techniques for
Assistive Living
Authors: Agarwal Preeti , Alam Mansaf
Published: September 2023

Purpose:

Human Activity Recognition (HAR) is a subject of research that identifies an individual’s
activities for assistive living. The proliferation of ICT and sensor technology prompted
HAR to flourish beyond unfathomable levels, having immense human-centric applications. The development
of accurate HAR systems involves complex statistical and computational tasks from signal
acquisition to activity classification. This research aims to conduct a systematic review of recent techniques
proposed for each stage of HAR application development.

Methodology:

The review is conducted following Kitchenham principles, using Scopus and Web of
Science databases. Firstly, research questions were formulated, followed by the search strategy definition.
Based on assessment criteria, 193 papers are shortlisted and thoroughly analyzed to extract research-
related information.

Results:

The techniques identified in 193 articles are comprehensively mapped from four aspects: data
acquisition, data preprocessing and feature engineering, learning algorithm, and evaluation. Each
technique is examined for its strengths and limitations to assist application developers in selecting the
best one for their needs. The prevailing challenges and upcoming research opportunities are thoroughly
explored.

Conclusion:

The ever-expanding literature in the field necessitated an update to the status of HAR literature.
Compared to other reviews that focused on specific methods, fields of application, and
datatypes, to the best of our understanding, this is the first evaluation of its kind that provides a broader
mapping of HAR approaches. The findings of this analysis will provide researchers and newcomers
in the field an up-to-date and holistic view of the complete body of work in this area.
Synthesis and Characterisation of Porous Carbide-derived Carbon from SiC in Molten Salt
Authors: Zheng Kai , Shi Cuilian , Li Jierui , Su Xiangdong
Published: September 2023

Aims:

In this paper, we aimed to prepare SiC-CDC with porous structure
from SiC precursor by using simple molten salt electrochemical etching method at 900
ºC in argon at an applied constant voltage of 3.0 V.

Background:

Nanoporous materials include carbon materials, silica or alumina, gel,
and zeolite, which have been known since ancient times. Among all these materials,
carbon materials are particularly outstanding. In recent years, carbide-derived carbon
(CDC), a type of unconventional carbon material produced by selectively extracting
metal elements from the lattice of carbides, has attracted increasing attention from researchers.
Many different methods have now been proposed to prepare CDC, among
these methods, currently the preparation of mesoporous carbide-derived carbon (CDCs)
materials mainly relies on chlorination. The main problems with chlorination are the
corrosion of chlorine gas and the treatment of secondary products (MClx). Therefore,
the search for environmentally friendly strategies for the production of CDC is still ongoing.

Objective:

This article proves that we can successfully prepare SiC-CDC with porous
structure from SiC precursor by using simple molten salt electrochemical etching method
at 900ºC in argon at an applied constant voltage of 3.0 V.

Methods:

The SiC-CDC with porous structure has been prepared from SiC precursor by
using simple molten salt electrochemical etching method at 900ºC in argon at an applied
constant voltage of 3.0 V.

Results:

The results show that the nanoporous SiC-CDC was successfully synthesized
from the silicon carbide microspheres powder via by electrolysis in molten CaCl2 at 3.0
V, 900°C for 15 h.

Conclusions:

The nanoporous SiC-CDC was successfully synthesized from the silicon
carbide microspheres powder via by electrolysis in molten CaCl2 at 3.0 V, 900°C for 15
h and their microstructure, specifc surface area, and pore size were analyzed. The SiCCDC
obtained in this experiment mainly consisted of amorphous carbon and maintained
the shape of SiC particles. The SiC-CDC is a mixture of amorphous carbon and ordered
graphite phase with a highly degree of graphitization. The SiC-CDC displays a BET
specific surface area of 561.39 m2/g and a total pore volume of 0.39 cm3/g. This method
to produce SiC-CDC is very attractive because it will not only pave a new way for the
preparation of SiC-CDC but also for mass production of high-quality carbon material.
Digging into the receptive and productive knowledge of phrasal verbs among Arab EFL English
Authors: Albaqami Rashidah
Published: September 2023

Foreign language learners often encounter challenges in understanding and using English phrasal verbs (PVs) due to its idiomaticity and complexity. A phrasal verb typically comprises a verb and a preposition, e.g., pick up, look after, and result in. The study attempts to determine the extent to which frequency of occurrence facilitates or hinders mastering the target forms among English Foreign Language (EFL) learners. This study attempts to examine frequency of occurrence as a factor that might account for EFL learners’ receptive and productive knowledge of PVs. English belongs to the Germanic language family and hence it shares some common linguistic features with other members of the language family, e.g., German has detachable prefix verbs (e.g., warten auf) in a way resembling the English phrasal verb (e.g., wait for). On the other hand, other language families such as Semitic languages (e.g., Arabic), rely heavily on single word-verbs (SVs) (e.g., y?nt??r ‘wait’ in Arabic). For this purpose, a total of 37 high school female students in Jeddah (Saudi Arabia) took part in the current study.
Study of Cracker Production with the Addition of Black Garlic and Sodium Tripolyphosphate
Authors:   University of Jember, Herlina Herlina , Yuwanti Sih ,   University of Jember, Maulana Aditya Bagas ,   University of Jember, Lindriati Triana ,   University of Jember, Nurhayati Nurhayati ,   University of Jember
Published: September 2023

This study examines how black garlic and sodium tripolyphosphate (STPP) concentrations effect cracker physical, chemical, and organoleptic characteristics, also determined the black garlic and STPP optimal concentration to produce cracker with desirable quality. A completely randomized design was used, with two factors: black garlic concentration (3%, 6%; 9%) and STPP concentration (0.1%; 0.3%; 0.5%). The test parameters were color (lightness), swelling power, hygroscopicity, water content, ash content, total polyphenols, antioxidant activity, and organoleptic tests (color, flavor, taste, crispiness, and overall). An effectiveness test was conducted to determine the black garlic and STPP right concentration in cracker production. The results showed that the black garlic concentration significantly effected the lightness, swelling power, hygroscopicity, water content, ash content, antioxidant activity, and total cracker polyphenols. STPP concentration significantly effected the cracker ash content. Garlic and STPP concentration had significant organoleptic effects on color preference, flavor, taste, and crispiness. The cracker with a concentration of 3% black garlic and 0.5% STPP were the best and preferred. The effectiveness score was 0.64, with physical characteristics of color lightness 23.39 ± 0.20, swelling power 82.51 ± 0.11%, hygroscopicity 5.07 ± 0.41%, and chemical characteristics of water content 5.83 ± 0.16%, ash content 2.77 ± 0.25%, total polyphenols 0.175 ± 0.001%, antioxidant activity 16.14 ± 0.20. The organoleptic test scores were color 6.00±0.12, flavor 5.60±0.43, taste 5.68±0.31, crispiness 6.92 ± 0.32, and overall 6.28 ± 0.42.
The Development of Strategies to Increase the Productivity of Fisheries Agro-industry Based on Halal Product Assurance System Using Failure Mode Effect Analysis (FMEA)
Authors:   Universitas Muhammadiyah Sidoarjo, Wahyuni Hana Catur , Handayani Puspita ,   Universitas Muhammadiyah Sidoarjo
Published: September 2023

Indonesian food products need to comply with halal regulations, including the ones from fisheries-based agro-industry. The absence of halal certificates will limit the market and consequently will lead to the risk of lower productivity performance. This study aims to identify sources of risk in the fisheries agro-industry based on Indonesia’s Halal Assurance System called Sistem Jaminan Produk Halal (SJPH). It conducts risk assessments and develops strategies to increase the productivity performance of the industry based on the identified risks. The criteria considered in the risk identification including commitment and responsibility, raw material, production process, final product as well as monitoring and evaluation. The research used Failure Mode Effect Analysis (FMEA). The data was collected through observation, interviews, and questionnaires. All identified risks were then evaluated and eliminated based on the Risk Priority Number (RPN). The research was conducted on ten fisheries-based agro-industries in the Sidoarjo Regency, East Java, Indonesia. The study shows that there are 22 sources of risk, with the highest-ranked one is training activity. The recommended strategy to increase the halal-based productivity performance is strengthening the commitment of all involved stakeholders, increasing human resources' knowledge, improving facilities and infrastructure as well as strengthening monitoring and evaluation using management information systems.
Diseño de un sistema de control de prótesis transfemoral basado en redes neuronales
Authors: Vergara Sofía , Mosquera Guillermo , Bonilla Vladimir , Sánchez Miguel , Rueda Christian
Published: September 2023

En el presente proyecto se desarrolló el control de una prótesis transfemoral por medio de una red neuronal. Se utilizó la metodología mecatrónica basada en el modelo en V. Primero se presenta un análisis a la situación de discapacidades físico-motoras de Ecuador y se revisan algunos diseños de prótesis para proponer una solución local. Se plantearon requerimientos que se usaron como insumos para el desarrollo del diseño conceptual y específico. Se estableció el sistema de adquisición de datos para realizar las mediciones de actividad muscular y posición por medio de un acelerómetro. Se entrenó una red neuronal formada de una capa de 3 entradas con 12 neuronas en la capa oculta y una neurona en la capa de salida. La salida de la red corresponde a la posición a la que debe llegar la prótesis, y el sistema desarrollado tiene un error del 20% en la predicción de los movimientos de flexión y extensión de la pierna.
Appeal of editor-in-chief
Authors: Author No
Published: September 2023

No abstract
Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome
Authors: Bilchenko A.O. , Kopytsya M.P. , Petyunina O.V. , Vishnevskaya I.R. , Rodionova Iu.V.
Published: September 2023

Background. Coronary artery disease (CAD) persistently remains the leading cause of mortality globally. Given the severity and impact of this condition, researchers have been meticulously studying the pathogenesis of athe-rosclerosis, a principal cause behind CAD. The pathogenesis stages are complex and multifaceted, including factors such as lipid accumulation, inflammation, and plaque formation. A particular area of active exploration pertains to the influence and role of different biomarkers, including matrix metalloproteinase 9 (MMP-9) and myeloperoxidase (MPO), on these processes. These biomarkers have been associated with the progression and destabilization of athe-rosclerotic plaques, which are central to CAD. However, the use of these biomarkers in the context of comorbidities, such as chronic kidney disease, remains an open area of research, especially in patients after myocardial infarction. Materials and methods. In our study, 96 patients who had acute coronary syndrome and subsequently undergone percutaneous coronary intervention were enrolled. They were stratified into groups (A and B) based on respective glomerular filtration rates. The primary endpoint of the study was all-cause mortality and major adverse cardiovascular and cerebrovascular events. Results. Our analysis revealed that serum levels of MPO in group B were insignificantly higher than those in group A. Conversely, the area under the receiver operating characteristic (ROC) curve for MMP-9 in group A exhibited a significant difference, standing at 0.8 (95% confidence interval 0.609–0.991; p = 0.039). However, the ROC curve for MPO did not yield a significant result in any group. A combined ROC curve was also generated, with the area under this curve showing a significantly higher value of 0.890 (95% confidence interval 0.805–0.975; p < 0.001). Conclusions. We found that plasma levels of the above-mentioned biomarkers do not seem to influence a decrease in glomerular filtration rate. Nonetheless, MMP-9 levels offered significant prognostic information regarding predicted outcomes.
Perioperative thrombocytopenia: review of current recommendations and implementation in clinical practice
Authors: Ploshchenko Yu.O. , Novikov S.P. , Gavrish K.V. , Kusch V.M. , Karas R.K.
Published: September 2023

Thrombocytopenia is a heterogeneous group of disorders characterized by a platelet count below the lower limit of normal (150 × 109/L), and detection of this disorder during hospitalization is a fairly common phenomenon. Thrombocytopenia is often observed in patients of various profiles: in cardiology, obstetrics and gyneco­logy, cancer, neurology and general therapeutic departments and can occur as an independent condition or as a separate symptom of various diseases affecting the blood coagulation system. The etiology of thrombocytopenia in critical illness is often complex and multifactorial. Thrombocytopenia and possible bleeding represent significant risks for the anesthesiologist in the perioperative period, which affects the need for special attention to a patient during preoperative preparation, choosing the optimal method of anasthesia taking into account all factors, and high-quality postoperative intensive care. In our article, we reviewed the current proposed approaches to perioperative thrombocytopenia to achieve a safe positive treatment outcome and, using the example of two clinical cases, showed the possibility of successful use of strategies such as administration of steroids, antifibrinolytic agents, intravenous globulin, thrombo-poietin receptor agonists, and hematocrit optimization in conditions of the joint work of a multidisciplinary team — anesthesiologists, surgeons and hematologists. To improve the results of treatment for thrombocytopenia and to minimize the risks in the perioperative period, we recommend a multidisciplinary approach to the preparation and management of such patients and the individual use of various perioperative strategies to increase the number of platelets and reduce intraoperative bleeding in case of thrombocytopenia of various etiologies.
Strengthening community empowerment for elderly health service in new normal by Pol-Sadar (Integrated Health Service Post for Elderly)
Authors: Hani Umi , Mendrofa Fery Agusman Motuho
Published: September 2023

Before the pandemic, older people actively participated in an integrated health service post named POSYANDU. This high participation is due to community health workers who understand their role in realizing basic health services. During the pandemic, POSYANDU must be held with attention to developments in the COVID-19 case. We implemented the online-based service of integrated health posts to provide online health services for older people. This paper explains the participation of elders, family, and community health workers in the revitalization strategies of integrated health service activities for older people during the pandemic. The activities included health assessments via telemedicine (video call), drive-thru services for vital signs assessment and simple lab checks, home visits, and education via WhatsApp as needed. The implementation began in June 2020 and in May 2021 with 184 older people in some places in Central Java, including Semarang City, District of Semarang, and District of Batang. We also worked with teaching volunteers consisting of five community health workers and 19 nursing students in the community. The results of these activities were the findings of health problems experienced by the elderly during the pandemic (depression, hypertension, and joint stiffness), increased knowledge, and physical activity in the elderly group. The 100 older people participated in online exercise activities accompanied by their families and felt a decrease in complaints of joint stiffness, and 84 elders people participated in health education and exercise activities in open areas by implementing strict health protocols. Most participants said they were satisfied with Pol-Sadar activities as a health service strategy for older people during the pandemic. In conclusion, the online program was effective as a strategy of health services for elderly people, especially during the new normal era, and increased the participation of family and community health workers, but it needs adequate devices to participate.
Increasing the Health-Related Quality of Life in Children with Congenital Rubella Syndrome: A Mixed-methods Study
Authors: Herini Elisabeth Siti , Triono Agung , Iskandar Kristy , Prasetyo Ashadi , Nuady Albaaza , Hadiyanto Marissa Leviani , Diantika Kania , Wijayanti Veronica Wulan , Pramastuti Avianti
Published: September 2023

Background: Rubella infection during the first trimester of pregnancy is a significant cause of fetal malformation syndrome, known as Congenital Rubella Syndrome (CRS). The most prevalent abnormalities associated with CRS are hearing loss, vision impairment (primarily congenital cataracts), congenital heart disease, and global developmental delay affecting the children's quality of life (QoL). A Community Engagement Program was arranged collaboratively to increase the QoL of children with CRS and enhance parents' skills and knowledge to better care for their children with CRS.Methods: A mixed-method descriptive study was conducted to assess the QoL improvement in children with CRS and to determine parents' knowledge about CRS. Children's QoL data were obtained using the Pediatric Quality of Life Inventory (PedsQL)TM 4.0 Generic Core Scales and analyzed with paired T-tests. A survey and focus group discussion  (FGD) were used to gather parents' knowledge about CRS.Results: We involved ten members willing to participate voluntarily in the PedsQL assessment and FGD. The result was an increase in patients' QoL in the Physical Function domain that was statistically significant: pre-test and post-test physical health summary (490 (±261) vs. 510 (±251); p=0.022), social (322 (±126) vs. 337 (±113); p=0.217), emotional (370 (±105) vs. 397 (±105); p=0.065), and school (342 (±94) vs. 355 (±97); p=0.586). From the survey and the FGD, the parents had diverse experiences and understanding of CRS-supporting examinations and treatments needed. Parents felt the children's growth and development, social and school functions were the common burdens. In order to help CRS prevention, the parents suggested a more comprehensive premarital program and antenatal care.Conclusions: The Community Engagement Program helps to increase the patients’ QoL in the Physical Function domain. Comprehensive multidiscipline management is needed to support children's growth, social function, and educational function. Periodic evaluations are required to monitor the QoL of children with CRS.
Immunization Program Intervention Training in Stunting Prevention Effort in Sampang Regency, Madura Island, East Java
Authors: Artanti Kurnia Dwi , Hargono Arief , Yamani Laura Navika , Fadhilah Farah , Hasan Taufiq Hidayat
Published: September 2023

Stunting was still a major health problem in Indonesia. Sampang Regency was one of the districts that experienced an increase in the prevalence of  Stunting.  According to the 2018 Riskesdas data, it shows that one in three babies under two years old (baduta) and babies under five years old (toddlers) in Indonesia are in the stunting category. To prevent stunting, intervention was needed to increase the number of immunization. The aim in this activity was to identify the barrier increasing Universal Coverage Immunization (UCI) to solve immunization problem by Human Centered-Design (HCD) method.  The method used is a qualitative method using HCD, which is a method used to explore problems from the community side. This activity was involved by the head of the epidemiology and immunization section, the program holders of the Sampang district health office, coordinating midwives and immunization coordinators at selected health centers regarding immunization program interventions, namely exploring immunization problems from the community. The HCD intervention method has several steps, namely Persona, Journey of Map, Quote, Findings and Suggestions. The results from the intervention was every public health centers known to have a different picture related to portraits of people in the community who are influential in the implementation of the immunization program. This program showed that health was not only the responsibility of government or the health program holders, but everyone. The recommendations from the HCD training at the two public health centers agreed to re-advocate the immunization program to relevant stakeholders.
Extra-Judicial Killings in Papua, Indonesia Reflections on Violation and State Authoritarianism Toward Papuans
Authors: Saadah Aliyah Almas
Published: September 2023

This article aims to elaborate on and explore extrajudicial killings, i.e.,the human rights violations conducted by Indonesian state security forces in Papua. Such unlawful executions are tightly intertwined with the history of torture and forced disappearance during the lengthy conflict in Papua and West Papua. Despite claiming numerous victims, security officials have never been held fully accountable for extrajudicial killings due to their “legal impunity” and the lack of political will to bring perpetrators to trial. Importantly, this article shows that the reported killings are only the tip of the iceberg, as human rights experts and scholars believe there are many more profound and severe violations of Papuans’ rights. Journalists’ limited access to documents, as well as general non-disclosure, has created speculation that numerous human rights violations have occurred but gone unreported. First, we urge the government to recognise extrajudicial killings as gross and severehuman rights violations, as defined by international law. Second, the government must comprehensively review police, military, or other security officials’ fieldwork and use of firearms and physical force when arresting suspects.
The Participatory Resilience of Waste Pickers at the Bantargebang Waste Processing Site after Land Degradation
Authors: Titisia Denti , Wicaksani Dinie Wulan , Rif'an Fadil Ainur
Published: September 2023

This study discusses the participatory resilience of the waste pickers at the Bantargebang Waste Processing Site by analysing the link between the waste pickers’ resilience and public participation after land degradation occurs. Similar studies use qualitative evidence to understand how public participation is driven by the issue of land degradation. However, this approach also begs the question as to the roles of the actors and publics involved. This study thus divides actors into two categories, i.e., implementing actors and capital-holding actors. More specifically, this study seeks to understand the realisation and practice of participatory resilience in Bantargebang. For data collection, three methods were used: library research, interviews, and observations.
Pengaruh Modal Sosial pada Pembentukan Public Sphere di Twitter: Studi Kasus Isu Tes Wawasan Kebangsaan KPK dengan Pendekatan Kuantitatif Relasional
Authors: Pradana Meirza Luthfi
Published: September 2023

Kajian ini membahas bagaimana peran modal sosial dalam meningkatkan keterlibatan aktif oleh netizen pada public sphere di media sosial. Modal sosial merupakan sekumpulan nilai informal yang menyebar di antara anggota kelompok sehingga memungkinkan terjadinya kerja sama kolektif. Tulisan ini menggunakan isu tes wawasan kebangsaan Komisi Pemberantasan Korupsi (TWK KPK) sebagai studi kasus. Sebab, isu ini berkaitan dengan adanya wacana pelemahan KPK yang dilakukan oleh penguasa. Kajian ini mengambil pendekatan kuantitatif relasional melalui Social Network Analysis (SNA) dan analisis sentimen. Visualisasi SNA berbentuk nodes dan edges menampilkan informasi berupa top influencer dan top engaged tweets. Analisis sentimen diukur dengan tiga metrik, yakni amplifikasi, aplaus, dan tingkat percakapan per unggahan. Data pada kajian ini diperoleh dari Twitter yang telah diolah dengan instrumen Big Data Analytics. Rentang waktu pengambilan data dilakukan dari tanggal 16 Mei hingga 13 September 2021. Hasil kajian memperlihatkan bahwa aktor-aktor dengan kredibilitas tinggi di dunia nyata memanfaatkan modal sosial yang dimiliki saat menggunakan Twitter. Karenanya, terjadi peningkatan keterlibatan aktif oleh netizen lewat banyaknya muatan sentimen yang diperoleh. Mayoritas citra sentimen dalam kajian ini didominasi oleh sentimen negatif atau mengindikasikan kontra terhadap pelaksanaan TWK KPK.
УГЛУБЛЕНИЕ САМОКОНТРОЛЯ КОНТРОЛЬНО-­ПРОВЕРОЧНОЙ АППАРАТУРЫ ИЗДЕЛИЙ СИСТЕМ УПРАВЛЕНИЯ: МИГРАЦИЯ С WINDOWS НА LINUX
Authors: Белов C.
Published: September 2023

В статье описываются проблемы, выявленные при осуществлении попытки миграции с ОС Windows на ОС Linux применительно к ПО самоконтроля КПА изделий систем управления. Выяснилось, что миграция повлияет на алгоритмы самоконтроля: потребуется создание и углубление самоконтроля самой ОС, ее совместимости и взаимодействия с платами расширения.
ИССЛЕДОВАНИЕ ВЛИЯНИЯ УГЛА НАКЛОНА ЩУПА И РАСПОЛОЖЕНИЯ ТОЧЕК КАСАНИЯ НА ТОЧНОСТЬ ИЗМЕРЕНИЯ КРУГЛОМЕРОМ ROUNDTEST RA 120P
Authors: Епифанцев К. , Ефремов Н.
Published: September 2023

Рассмотрена проблема повышения точности измерений отклонений формы деталей на кругломере RoundTest RA 120P. Полученные результаты будут полезны при планировании и проведении измерений и контроля деталей (тел вращения) на кругломере RoundTest RA 120P.
РАЗРАБАТЫВАЕМЫЙ АО «АНГСТРЕМ» 32 РАЗРЯДНЫЙ УНИВЕРСАЛЬНЫЙ МИКРОКОНТРОЛЛЕР «ТРАССА 1П»: ХАРАКТЕРИСТИКИ И ПЕРСПЕКТИВЫ РАЗВИТИЯ
Authors: Шишарин А.
Published: September 2023

Рассмотрен 32 разрядный универсальный микроконтроллер «Трасса 1П», разрабатываемый АО «Ангстрем». Приведена информация о характеристиках и перспективах развития данного микроконтроллера.
ФОТОПЬЕЗОЭЛЕКТРИЧЕСКИЙ ПРИЕМНИК ОПТИЧЕСКИХ СИГНАЛОВ НА ПОВЕРХНОСТНЫХ АКУСТИЧЕСКИХ ВОЛНАХ
Authors: Митрохин В. , Строгонов А. , Гуров А. , Лялин Д.
Published: September 2023

В статье описан принцип действия и топология полупроводникового приемника оптических сигналов на поверхностных акустических волнах, обладающего избирательностью по частоте модуляции оптического сигнала.