bluuebunny/crossref_metadata_2025 huggingface dataset:
On-line monitoring of downstream purification processes for VSV based SARS-CoV-2 vaccine by a novel technique
Authors: Makovitzki Arik , Jayson Avital , Oren Ziv , Lerer Elad , Kafri Yaron , Dor Eyal , Cherry Lilach , Tzadok Hanan , Levin Lilach , Hazan Ophir , Simon Irit , Tal Arnon , Girshengorn Meni , Rosen Osnat
Published: June 2021

The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) increases the need for rapid development of
efficient vaccines. Among other vaccines in clinical trials, a
recombinant VSV-∆G-spike vaccine was developed by the Israel Institute
for Biological, Chemical and Environmental sciences (IIBR) and is being
evaluated. Development of an efficient downstream purification process
(DSP) enables advancing the vaccine to clinical trials. The DSP must
eliminate impurities, either process- or product -related, to yield
sufficient product with high purity, potency, and quality. To acquire
critical information on process restrictions and qualities,
incorporation of on-line monitoring is vital. Application of on-line
monitoring should significantly impact process yield, product quality
and economy of the entire process. Here, we describe an on-line
monitoring technique that was applied in the DSP of the VSV-∆G-spike
vaccine. The technique is based on determining concentrations of
metabolites, nutrients and a host cell protein (HCP) by the automatic
chemistry analyzer Cobas Integra 400 Plus. The analysis revealed
critical information on process parameters and significantly impacted
purification processes. The technique is rapid, easy and efficient.
Adaptation of this technique during the purification process improves
process yield, product quality and enhances the economy of the entire
downstream process of biotechnology and bio pharmaceutical products.
Assessing the utility of CASP14 models for molecular replacement
Authors: Millán Claudia , Keegan Ronan , Pereira Joana , Sammito Massimo Domenico , Simpkin Adam , McCoy Airlie , Lupas Andrei N. , Hartmann Marcus , Rigden Daniel , Read Randy
Published: June 2021

The assessment of CASP models for utility in molecular replacement is a
measure of their use in a valuable real-world application. In CASP7, the
metric for molecular replacement assessment involved full
likelihood-based molecular replacement searches; however, this
restricted the assessable targets to crystal structures with only one
copy of the target in the asymmetric unit, and to those where the search
found the correct pose. In CASP10, full molecular replacement searches
were replaced by likelihood-based rigid-body refinement of models
superimposed on the target using the LGA algorithm, with the metric
being the refined likelihood (LLG) score. This enabled multi-copy
targets and very poor models to be evaluated, but a significant further
issue remained: the requirement of diffraction data for assessment. We
introduce here the relative-expected-LLG (reLLG), which is independent
of diffraction data. This reLLG is also independent of any crystal form,
and can be calculated regardless of the source of the target, be it
X-ray, NMR or cryo-EM. We calibrate the reLLG against the LLG for
targets in CASP14, showing that it is a robust measure of both model and
group ranking. Like the LLG, the reLLG shows that accurate coordinate
error estimates add substantial value to predicted models. We find that
refinement by CASP groups can often convert an inadequate initial model
into a successful MR search model. Consistent with findings from others,
we show that the AlphaFold2 models are sufficiently good, and reliably
so, to surpass other current model generation strategies for attempting
molecular replacement phasing.
Arterial Tortuosity Syndrome
Authors: ARUNAKUMAR PRIYADARSHINI , Marimuthu Varun , MK Usha , M Jayaranganath
Published: June 2021

A rare autosomal recessive condition, Arterial tortuosity syndrome (ATS)
presents with ectactic blood vessels, cutaneous laxity, and bowel
rupture. We report a case of an asymptomatic infant with arterial
tortuosity syndrome who presented with left ventricular hypertrophy
without any obvious obstruction to the outflow tract.
The definitions of health care and social welfare informatics competencies
Authors: Tiainen Minna , Ahonen Outi , Hinkkanen Leena , Rajalahti Elina , Värri Alpo
Published: June 2021

Digital transformation is changing the ecosystem and at the same time professionals’ competencies worldwide. Minimising health care and social welfare costs while increasing citizens’ health and well-being is challenging. Technology and digital tools play an important role in reaching this goal. However, there are inequalities concerning technology, and this has many impacts. Digitalisation brings challenges not only to health care and social welfare professionals but to citizens, too. Working with or using services in digital environments demands new skills. This has social and ethical impacts, e.g. how is equal access to services ensured. Health and social care professionals should have different competencies to respond to this, such as societal competencies. The purpose of this article is to describe how the definition of competencies in health care and social welfare version 1.0 (developed in the national SotePeda 24/7 project) was finalised as the final version 2.0 for Finnish healthcare and social welfare education by experts’ evaluation.
Data was collected through an electronic questionnaire administered to selected experts (N=140) during January 2020. The number of experts who responded to the study was 52. These experts (social and health, business and IT) work or have worked in tasks related to the digitalisation of social and health care. The questionnaire was based on version 1.0 of the definition of digital competencies of health care and social welfare informatics. The questionnaire was mainly quantitative, but it also included open-ended qualitative questions. The experts agreed to a large extent on the version 1.0 definition, but some adjustments were made to the definition based on our study. The resulting definition is intended for use in the planning, implementation and evaluation of health care and social welfare education, but it can also be used for polytechnic education. The aim is to develop the digital skills of educators, degree students and in-service trainees in a multidisciplinary way (social and health, business and IT) to meet the needs of working life.
Customer value creation in the development of digital health services: discourse analysis
Authors: Vieresjoki Paula , Kämäräinen Laura , Laukka Elina , Suhonen Marjo , Kanste Outi
Published: June 2021

The study’s aim was to describe how customer value creation is reflected in the development of digital health services. To this end, we used discourse analysis to evaluate documentation from the ODA (Self-Treatment and Digital Value Services) project, which provides national-scale digital health services.
Three main discourses emerged: 1) a discourse on the active role of the customer, 2) a discourse on technology that activates the customer to create value, and 3) a discourse on the benefits of customer value creation.
The research provided new insight into customer value creation in digital health service development. Speech about customer value creation was a part of the social reality of the digital health service’s development. The customer appeared as an active player and a key resource within the service. The role of the active customer was considered demanding and responsible. Our findings suggest that the new digital service changed customer behavior, with technology acting as an enabler of this change. Customer activity and information sharing were seen as enablers of value creation and the associated benefits, and there was a willingness to strengthen the customer’s role as a need determiner.
Experiences of Navigator, a Finnish patient-segmentation service, in primary care: A mixed-methods study
Authors: Riihimies Riikka , Kosunen Elise , Koskela Tuomas
Published: June 2021

Aging and multimorbid populations burden health services worldwide. Segmenting patients with similar health service needs into different groups and guiding care providers to tailor services to these groups could reduce this burden. Methods of patient segmentation have been based on, e.g., databases. However, the Finnish patient-segmentation innovation Navigator (Suuntima) considers patients’ perspectives on their coping in everyday life, as well as professionals’ views of the patients’ state of health. The segmentation is based on questions. The resulting care pathway related to the group helps professionals to coordinate patients’ health care and patients to utilize appropriate services.
This first part of Navigator’s validation study evaluates its feasibility and content and face validity. We assess the web-service’s user experiences at nurses’ appointments with diabetic patients, time consumption, and Navigator’s question relevance, comprehensiveness, and comprehensibility.
This mixed-methods study uses user experience questionnaires for both patients and professionals, and semi-structured focus-group interviews for professionals. We used descriptive statistics in the quantitative data analysis of the questionnaire study and thematic analysis to identify the codes and themes in the interview data.
All 304 Navigator queries were completed at appointments. Most patients found Navigator easy to use. It helped in considering their situation better and from new perspectives. Most patients did not find it too time-consuming. Most professionals found it easy to use and suitable for appointments and patient segmentation. The questions were easy and unambiguous, and they assisted in discussing new or sensitive issues. Most queries were completed in less than 19 mins and less time was used if the patient was assigned to the nurse. Thematic analysis raised five main themes: 1) Well-functioning web-service, 2) Stimulus for conversation and action, 3) Rationale to complete Navigator with a professional, 4) Training and experience ease the use of Navigator, and 5) Navigator's room for improvement. Subthemes were identified for three main themes.
We consider Navigator’s feasibility and face validity to be favorable. We suggest user instructions and the clarification of concepts to support the questions’ comprehensibility. Some patients may benefit from a nurse’s presence when responding to Navigator’s questions.
The skill gap and polarization of the software labour force
Authors: Hyrynsalmi Sonja , Rantanen Minna M , Hyrynsalmi Sami
Published: June 2021

The demand for high-skill and deep knowledge is a key characteristic for modern-day software business. In addition, the whole impact of information and communication technology (ICT) is seen as a cross-cutting element in different industries. The software industry in Finland is suffering from a severe labour shortage and the estimations of needed labour are ranging from 7,000 to 15,000 software professional. However, despite all development and research done, the question, whether the software companies are requesting more employers or are they looking for more diverse skills, remains unanswered. Furthermore, previously there has little if any discussion, on whose responsibility is to ensure that future software experts have the right kinds of skills and competencies to secure their successful work career. This study focuses on the skill polarization between software professionals, referred to as the ‘War of Talents’ in this study, by using data collected by a survey (n=90) from Finnish software businesses. The results reveal some indication of ongoing skill polarization in the ﬁeld and its possible impacts are discussed. Furthermore, the potential threatening impacts of the polarization process on the well-being in the information society are observed and reported. In addition, the paper proposes adding skill development applications among the offering of eWellbeing services due to the importance of work-related competencies to the self-image – and therefore also wellbeing – of individuals.
Molecular and cellular features of mandibular autografts studied using raman spectroscopy
Authors: Maksimov GV , Sashkina TI , Faskhutdinov DK , Slatinskaya OV , Saldusova IV , Zaychenko OV
Published: June 2021

Currently, biophysical studies are of great interest, the results of which are important for development of a method for diagnosis of the cells and tissue condition to be used in clinical practice. The study was aimed to use a non-invasive optical method (Raman spectroscopy) for assessment of changes in the composition and conformation of the molecules of the patient’s mandibular cells and tissues. This approach was proposed to increase the informativeness and effectiveness of studying the composition of autografts harvested for augmentation of alveolar processes with bone tissue deficiency (elective bone grafting). In the course of the study the bone tissue samples obtained from three patients aged 51–73 (two men and one woman) were assessed. Raman signals were detected, indicating the presence of phosphate groups and carbonate ions (such as СО3–2) of the inorganic bone components. Raman bands indicating the presence of collagen, red blood cell hemoglobin, proteins (C–N bonds), lipids (С–Н groups of fatty acids and phosphate groups of phospholipids), as well as their OH groups may be considered the markers of periosteum tissue. The general possibility was suggested of studying single cells of autografts using the markers, indicating the presence of collagen, hemoglobin, proteins, lipids (С–Н groups of fatty acids of lipids; phosphate groups of phospholipids), and their OH groups. According to the authors, the results obtained can provide a basis for development of the new method for diagnosis of autograft bone using the combination of Raman spectroscopy and light guides.
Issledovanie molekulyarno-kletochnyh harakteristik autotransplantatov nizhnej chelyusti s pomoshch'yu metoda spektroskopii kombinacionnogo rasseyaniya
Authors: Максимов Г. В. , Сашкина Т. И. , Фасхутдинов Д. К. , Слатинская О. В. , Салдусова И. В. , Зайченко О. В.
Published: June 2021

V nastoyashchee vremya bol'shoj interes predstavlyayut biofizicheskie isssledovaniya, rezul'taty kotoryh vazhny dlya formirovaniya metodologii diagnostiki sostoyaniya tkani i kletok v klinicheskoj praktike. Cel'yu dannoj raboty bylo prodiagnostirovat' izmeneniya sostava i konformacii molekul kletok i tkani nizhnej chelyusti pacienta s pomoshch'yu opticheskogo neinvazivnogo metoda (spektroskopiya kombinacionnogo rasseyaniya (KR). Dannyj metodicheskij podhod predlozhen dlya povyvsheniya informativnosti i effektivnosti issledovaniya sostava autotransplantatov, poluchennyh dlya augmentacii al'veolyarnyh otrostkov pri deficite kostnoj tkani (planiruemaya kostnaya plastika). V issledovanii ispol'zovali obrazcy kostnoj tkani troih pacientov v vozraste 51–73 let, dvoih muzhchin i odnoj zhenshchiny. V kostnoj tkani obnaruzheny KR-signaly, svidetel'stvuyushchie o nalichii fosfatnyh grupp i karbonat-ionov (tipa SO3–2) mineral'nyh komponentov kosti. Markerami molekul okolokostnoj tkani mogut byt' polosy, kotorye svidetel'stvuyut o nalichii kollagena, gemoglobina eritrocitov, belkov (C–N-svyazi), lipidov (S–N-grupp zhirnyh kislot i fosfatnyh grupp fosfolipidov), a takzhe ih ON-grupp. Pokazana principial'naya vozmozhnost' issledovaniya otdel'nyh kletok autotransplantatov s pomoshch'yu markerov, svidetel'stvuyushchih o nalichii kollagena, gemoglobina, belkov i lipidov (S–N-grupp zhirnyh kislot lipidov; fosfatnyh grupp fosfolipidov), i ih ON-grupp. Po mneniyu avtorov, rezul'taty mogut sluzhit' osnovoj dlya formirovaniya novoj metodologii diagnostiki kostnyh autotransplantatov s pomoshch'yu sovmeshcheniya KR-spektroskopii i svetovodov.
Persistenciya koronavirusa SARS-CoV-2 v telah umershih i mery zashchity ot inficirovaniya
Authors: Щеголев А. И. , Туманова У. Н.
Published: June 2021

Predstavlen analiz dannyh literatury o vremeni sohraneniya SARS-CoV-2 v telah umershih, putyah zarazheniya ot trupov bol'nyh s COVID-19 i neobhodimyh sposobah zashchity ot takogo zarazheniya. Pokazano, chto dlya SARS-CoV-2 harakteren dostatochno dlitel'nyj period persistencii v tkanyah i zhidkostyah tel umershih bol'nyh s COVID-19, a takzhe na razlichnyh poverhnostyah, pri etom naibolee dolgo virus sohranyaetsya na stal'nyh i plastikovyh izdeliyah, nahodivshihsya v soprikosnovenii s trupom. Soglasno proanalizirovannym dannym, vskrytie tel umershih bol'nyh s COVID-19 dolzhno prohodit' tol'ko v special'no pereprofilirovannyh otdeleniyah s obyazatel'nym soblyudeniem mer, obespechivayushchih biologicheskuyu bezopasnost', sotrudniki patologoanatomicheskih otdelenij i byuro sudebno-medicinskoj ekspertizy obyazany soblyudat' pri etom mery individual'noj i kollektivnoj zashchity.
Problems of students’ assessment in the process of distance learning (on the example of the EU countries)
Authors: Ridei Nataliia , Shevchenko Inna , Tytun Oksana , Pozharytskyi Oleksandr , Hensitska-Antoniuk Nataliia
Published: June 2021

The purpose is to determine the effectiveness of distance assessment, positive and problematic positions on the introduction of distance assessment in European higher education. The basic method of the research is the experimental method; empirical, statistical and theoretical methods have been also used. In order to carry out diagnostics on the effectiveness of the research, the survey method has been used. The basic hypothesis lies in the fact that changes in the students’ assessment system are positive, adaptable; prepared and properly implemented system will provide quality and objective control of knowledge and skills of students. The result of the research is proving of the effectiveness and prospects of the assessment system in the context of distance education; along with this, the difficulties and shortcomings are insignificant.
Potential relationship of internal control, internal audit and risk management in company – the case study of Vingroup in Vietnam
Authors: Hanh Hoang Thanh , Huy Dinh Tran Ngoc
Published: June 2021

There is interaction and relationship among internal control activities, internal audit and risk management in the firm, we conduct this study to address these functions in a case study of Vingroup in real estate industry in Vietnam , esp. We would like to mention potential relationship between these activities in companies and in this specific case. Authors mainly use experience and advice from experts, together with quantitative methods (statistics, calculation formulas) and qualitative methods including synthesis, inductive and explanatory methods.  Our study results show that. And because CPI, G has negative relation with ROE while Rf has positive relation with ROE, macro policies can help to control inflation and GDP growth not increasing much to be in favor of ROE of Vingroup and toward benefits for managing risk. Finally, through analysis and synthesis, we will give suggestions for better internal control mechanism, internal audit and risk management functions in companies as well as in a specific case of Vingroup.
KETETAPAN HUKUM DAN REKONSTRUKSI PARAMETER HILAH PADA PRAKTIK PERBANKAN SYARIAH
Authors: Maulana Diky Faqih , Rozak Abdul
Published: June 2021

Many Islamic bank products and contracts are not in accordance with sharia principles. This research will discuss in detail the related hilah in Islamic banking practices and the differences in bank interest with margins, fees, and profit sharing on Islamic bank financing. This research is a qualitative research which is literature study. The results showed that the use and parameters of hilah in syari'ah banking were different and it could be measured to what extent the practice violated the principles of syari'ah or not. Basically, the profit-sharing system, fees and margins are designed to bridge anti-usury groups, but not a few of the syari'ah banks use law to wrap a product or contract with the syari'ah label because in practice it is far from theory and principle. shari'ah. The standard of hilah, where a contract or product must meet Qasd al-shari ', Qasd al-mukallaf, Wasa'il, Maslahah, Rukhsoh and Azimah. If a contract or product meets the five parameters above then it is categorized as masyru'ah (which is permissible), but if it does not fulfill it, even the opposite, it is classified as mazmumah (which is prohibited).
Characterization of bioactive substances MHGF-68 on tumour cell lines with LiveFlow In Vitro Technology
Authors: Hodoši R. , Nováková E. , Macková K. , Molitorisová M. , Šupolíková M.
Published: June 2021

As part of experimental research, growth factor-like substances associated with MHV-68, named MHGF-68, were discovered in our laboratory. MHGF-68 activity was manifested by the ability to alter cell morphology, that is, normal phenotype to transformed, resp. suppresses the transformed phenotype of tumour cells. The aim of the experiments was to monitor the effect of MHGF-68 on the change of the cell actin cytoskeleton in the tumour cell line Hepa1c1c7, as well as the normal cell line NIH3T3, and compare conventional stationary cultivation and dynamic cultivation conditions using a LiveFlow system (In Vitro Technologies). LiveFlow is an advanced system to test the impact of different compounds on the cell cultures, which allows simulation of in vivo conditions thanks to continuous flow of cultivation medium. MHGF-68 was prepared with the infection of BHK-21 cells with MHV-68 virus under non-permissive conditions (41°C). After dynamic cultivation with MHGF-68, we observed changes in morphology on Hepa1c1c7 cells. In cells cultured in a dynamic environment, we observed more pronounced changes in cell morphology in comparison with cells cultured statically. We observed no changes in the cytoskeletal structures in the NIH 3T3 cell line affected by MHGF-68 in both types of cultivation. The advantage of LiveFlow in comparison to in vivo testing is that the experiments performed in this system are less time and money consuming. Dynamic cultivation in the LiveFlow system is suitable for optimizing experiments before testing substances in vivo.
Decision Analysis of the COVID-19 Vaccines
Authors: Ozsahin Dilber Uzun , Gelisen Mehmet Ilker , Taiwo Mustapha , Agachan Yasemin , Rahi Dorrin , Uzun Berna
Published: June 2021

The entire globe is struggling with the COVID-19 pandemic since March 11, 2020. There is still a large number of infected patients and death, and there is no proven treatment for the infection yet. This has led to the race in vaccine development to protect people from COVID-19 infection. As of February 3, 2021, there were 289 experimental COVID -19 vaccines in development, 66 of which were in clinical trials with different phases, and 20 of them were in phase 3.

This study aims to evaluate 15 important vaccines based on criteria such as the dose number, dosing schedule, storage advantages, efficacy, and side effect. In this evaluation, we use the fuzzy PROMETHEE approach, which is an important Multi-Criteria Decision Making (MCDM) technique. The importance level of the criteria is determined based on expert opinion. The result shows that the EpiVacCorona vaccine is the most effective vaccine to prevent COVID-19 infections based on the selected criteria and the importance level of each criterion.

The result obtained may change based on individual or expert’s priorities. Due to the use of different criteria for the ranking and different weightings of the criteria, the ranking result may differ. This study also shows the strengths and weaknesses of the selected vaccines and the applicability of the MCDM technique for the evaluation of COVID -19 vaccines.
Views, experiences and attitudes of community-living older people towards the FIT-at-Home fall prevention programme: A qualitative interview study / Sichtweisen, Erfahrungswerte und Einstellungen von sturzgefährdeten Menschen im höheren Lebensalter zum FIT-at-Home-Sturzpräventionsprogramm: Eine qualitative Interviewstudie
Authors: Müller Christian , Lautenschläger Sindy , Dörge Christine
Published: June 2021

Background

For older people, poor balance and strength as well as environmental hazards are a major risk factor for falls. A lifestyle-integrated home-based physical exercise training and home modification intervention were developed for older people at risk of falling.

Aim

This study aimed to examine older people's perceptions of the FIT-at-Home fall prevention intervention in order to further develop the intervention's content, procedures and mode of delivery.

Methods

We conducted semi-structured interviews with individuals who participated in the falls prevention programme using the problem-centred interview method. The interviews were analysed in a deductive-inductive approach following Mayring's qualitative content analysis.

Results

Seven themes emerging from the data described different facets of older people's perceptions towards the intervention. Findings suggested that the participants accepted the FIT-at-Home intervention. Overall, the individuals regard the intervention as feasible and practicable. From the older people's view, it was an advantage that the exercises could be implemented at any time without additional aids or equipment in-house and it was not necessary to visit the occupational therapy practice. Older people's experiences showed that feelings of success have a positive effect on the willingness to exercise. A perceived barrier influencing the implementation of exercises among older people was their own laziness, their general state of health and illnesses, their daily mood or meteor sensitivity.

Conclusion

The FIT-at-Home intervention comprising balance and strength exercises and home modification is feasible and acceptable for community-living older people. Older people's feedback will help us to further refine the intervention.
Statutory, effective, and optimal net tax schedules in Lithuania
Authors: Cerniauskas Nerijus , Jousten Alain
Published: June 2021

We estimate effective and optimal net income tax schedules and compare them to the estimated statutory rates for the case of Lithuania for the period 2014–2015. Values of effective net tax rates are estimated from the survey of EU Statistics on Income and Living Conditions; the statutory net tax rates are estimated with the European tax-benefit simulator EUROMOD, whereas optimal net taxes are calculated via Saez (2002) methodology. We find that the three net tax schedules are similar for employees in the middle of the income distribution. At the bottom of the income distribution, optimal net tax schedules suggest higher in-work benefits. The net tax schedules diverge substantially for the self-employed. At the top of the income distribution, where the majority of self-employed are concentrated, the self-employed are required to pay 15 cents less net taxes per Euro than employees—and they effectively pay 29 cents less.
Embedding-based Detection and Extraction of Research Topics from Academic Documents Using Deep Clustering
Authors: Vahidnia Sahand , Abbasi Alireza , Abbass Hussein A.
Published: June 2021

Purpose

Detection of research fields or topics and understanding the dynamics help the scientific community in their decisions regarding the establishment of scientific fields. This also helps in having a better collaboration with governments and businesses. This study aims to investigate the development of research fields over time, translating it into a topic detection problem.

Design/methodology/approach

To achieve the objectives, we propose a modified deep clustering method to detect research trends from the abstracts and titles of academic documents. Document embedding approaches are utilized to transform documents into vector-based representations. The proposed method is evaluated by comparing it with a combination of different embedding and clustering approaches and the classical topic modeling algorithms (i.e. LDA) against a benchmark dataset. A case study is also conducted exploring the evolution of Artificial Intelligence (AI) detecting the research topics or sub-fields in related AI publications.

Findings

Evaluating the performance of the proposed method using clustering performance indicators reflects that our proposed method outperforms similar approaches against the benchmark dataset. Using the proposed method, we also show how the topics have evolved in the period of the recent 30 years, taking advantage of a keyword extraction method for cluster tagging and labeling, demonstrating the context of the topics.

Research limitations

We noticed that it is not possible to generalize one solution for all downstream tasks. Hence, it is required to fine-tune or optimize the solutions for each task and even datasets. In addition, interpretation of cluster labels can be subjective and vary based on the readers’ opinions. It is also very difficult to evaluate the labeling techniques, rendering the explanation of the clusters further limited.

Practical implications

As demonstrated in the case study, we show that in a real-world example, how the proposed method would enable the researchers and reviewers of the academic research to detect, summarize, analyze, and visualize research topics from decades of academic documents. This helps the scientific community and all related organizations in fast and effective analysis of the fields, by establishing and explaining the topics.

Originality/value

In this study, we introduce a modified and tuned deep embedding clustering coupled with Doc2Vec representations for topic extraction. We also use a concept extraction method as a labeling approach in this study. The effectiveness of the method has been evaluated in a case study of AI publications, where we analyze the AI topics during the past three decades.
Exploring Political Parties on Facebook: Literature Review of the Two Main Political Parties in Ghana
Authors: Demuyakor John
Published: June 2021

Ghana currently has over 25 registered political parties. The two key political parties in Ghanaare the New Patriotic Party (NPP) and National Democratic Congress (NDC). Before the introductionof social media, especially Facebook, political parties in Ghana employed traditional communicationstrategies, such as TV, Radio, and News Papers, to execute political communication. However, since2012 political parties in Ghana have deployed and relied heavily on social media platforms, partic-ularly Facebook, as a political communication tool to disseminate their political manifestoes to theelectorates in order to clinch political power.This article adopted a purely descriptive approach with an emphasis on document analysis toreview relevant information and literature for the study. Hence literature is sourced from secondarysources like a pool of online libraries, political party’s websites/Facebook pages, and other scholarlyresearch related to the subject under investigation. The objective of this paper is to carefully explorepolitical parties on Facebook, emphasizing the two main Political parties in Ghana, thus the NewPatriotic Party (NPP) and National Democratic Congress (NDC).
Machina Ex Machina Artificially Intelligent Systems as Inventors under Polish Legal Framework
Authors: Bar Aleksandra
Published: June 2021

Not only do advanced artificially intelligent (AI) systems play an increasingly important role in modern society, but they also significantly enhance industrial and economic development. AI systems are already capable of generating outputs, which, had they been created by humans, would be eligible for patent protection. Polish patent regime has yet to determine how it will address inventive computational results. This paper aims at addressing a question whether AI-generated outputs can be considered patentable inventions under Polish legal framework and if so, who would be recognized as the inventor. The author draws conclusions de lege lata and briefly outlines de lege ferenda observations. The author argues that vesting the inventor status in one of the persons who contributed to the AI-generated result offers a reasonable incentive to actors involved in the innovation process and, at the same time, leaving aside vexed problem of computational personhood, does not undermine established legal paradigms, in particular the traditional notion of human creator (inventor).
Migration Law of the Commonwealth of Independent States
Authors: Beliakova Katsiaryna
Published: June 2021

The article presents multilateral agreements and acts of model legislation constituting the basis of developing migration law in the Commonwealth of Independent States (CIS). The author provides brief characteristics to the acts regulating cooperation in governing migration processes and the status of various types of migrants (both voluntary and forced), as well as model legislation designed to help unify and harmonize the legislation of the CIS member States in the relevant field. The results of the research show that the development of migration law in the CIS continues along the path of convergence with generally accepted norms and standards of international law, clarification of terminology, as well as systematization of model norms. At the same time, the implementation of the adopted norms remains problematic due to the lack of appropriate control mechanisms, as well as sanctions for non-compliance with these norms. In addition, the CIS maintains a special approach to countering illegal migration, which shows the priority of state security issues over the protection of human rights and this is also reflected in the terminology used.

The results of research may be used in comparative legal studies of migration law norms in regional legal systems.
The concept of institutionalised disintegration: towards a recognition of the EU institutions anew
Authors: Żukowski Alan
Published: June 2021

The main purpose of this article is to recognise an ongoing phenomenon of disintegration in legal terms. A specific role of the EU institutions is inevitable because of supranational relations’ nature and to-date momentum of public international law. Briefly, disintegration supported by the EU institutions may be the expected solution. Therefore, the concept of institutionalised disintegration is the author’s proposal for using the EU acquis to create a new (autonomous) treaty regime of public international law and to define the EU institutions anew. The basis for reconciliation of institutions and disintegration is to constitute the scientific method on so-called legal phenomena that combine dogmas and functions of law in general. Legal phenomena are correlated with de lege ferenda proposals that – mainly critically – react to current challenges. Challenges – in turn – are derived from a de lege lata analysis of the politico-legal system (especially understanding of the institution, mapping of disintegration and examination of legislative methods).
Bio-VLab: Virtual Laboratory Based on Android Educational Game
Authors: Aulia Najiyah Putri Sabilla , Dwisandi Reza Fauzi , Nizar Maulana Muhammad , Hernawati Diana
Published: June 2021

Virtual reality has a lot of potentials to be applied in the field of education and learning, known as virtual learning. For some learning activities there is quite a lot of interest in research about virtual learning. However, at present there is little virtual learning in the packaging of a virtual laboratory based on an Android educational game that presents a series of practical activities as a form of verification or confirmation of concepts learned by students. For this reason, this research aims to develop Bio-VLab, a game-based android mobile application, by adopting some of the ADDIE development procedures covering the analysis and design stages. Technical analysis was carried out descriptively qualitatively based on prototypes generated from the design of the development including initial appearance, class choices, list of materials, learning objectives, display of teaching aids, and practical content.
Teacher Perception of Implementation Learning Management System: CCR with Android Opensource
Authors: Ridlo Zainur Rasyid , Rusdianto Rusdianto , Bahri Samsul , Afafa Luthfin
Published: June 2021

The purpose of this research is mapping teacher perception on learning management system as second opinion in pandemic era. The methodology of research divided into three parts, namely preparation, action, and evaluation. The first step is preparation, include prepare to train the teacher to use CCR and android application opensourse. The second step is action, this section is most important in this research because in this section the teachers were practicing with CCR and android application within the teaching activities in online learning. After those steps, the final is evaluation, the teachers were evaluated using likert scale of the implementation of CCR and android open sourse. The result  of this research is most of the teachers feel easy in accessing CCR and android opensource application.
Enhancement Interest in Learning Mathematics for Children with Physical Disabilities at The Legs Using Wheelchair Playing and Learning
Authors: Hidayah Ayu Rahman , Aourah Putri , Ramadhani Ade Suci
Published: June 2021

The current educational phenomenon is the large number of children with physical disabilities at the legs. One the reason is the environment that does not provide opportunities for them to grow and develop with their conditions. Conducive and pleasant educational environment for children with physical disabilities at the legs in grades 2 and 3 of elementary school can create a better psychological condition with a sense of enthusiasm and interest to improve academic understanding of mathematics learning. Kuda Baja or Wheelchair Playing and Learning presents as a form of author's effort to overcome these problems. The author prepare this article is using the method of literature study. So in this article Kuda Baja as a wheelchair at once includes learning media with a playing method. There are two-dimentional figure puzzle, stacking numbers, abacus, napier bar tables, and is equipped with a whiteboard and a smartphone stand.
The Effect of Think Pair Share Learning Method Using Observation Approach Toward the Cognitive Learning Outcome of Senior High School Student Preferences the Study of Biology Lesson
Authors: Aslami Nurul , Suratno Suratno , Narulita Erlia
Published: June 2021

The current learning process of students is directed in a one way process. The teachers have to explain and the students are listening to them instead of being actively involved. It degrades their cognitive learning outcome. The application of Think Pair Share affects the students to become actively involved and giving an opportunity for those who want to comprehend their argument into the class. The additional approach of the method may support to make the students feel their own learning method which goes meaningful. The goal of this research is to know the role of Think Pair Share learning method toward the cognitive learning outcome of senior high school students. The research uses quassi experiments in terms of control class and experiment class approach. The result shows that the reduction of them are 33,53 and 17,21. The normality test result defines that the significance value is 0,0066 (>0,05). It means they have accepted H0, meanwhile the pretest and posttest mark of each class control and experiment distribute normally. The homogeneity test results show a value of 0.439 (> 0.05) so that H0 is accepted, which means that the pretest and posttest values from the experimental and control classes come from the same or homogeneous population. The result of ANACOVA test show that SPSS result is 0,000 (>0.05) so the H1 is accepted. It proves that Think Pair Share method using observation experiment is effectively significant towards the cognitive learning outcome of the students. From this situation, it concludes that the approach is having an impact into the cognitive learning outcome of the students
The Influence of Mathematics National Examination Scores on Grade Point Average, Mathematics Anxiety, and Self-Regulated Learning of 2018 Second Year Students
Authors: Rayoan Florianus Martinus , Ludji Ryan Anderson Dimu
Published: June 2021

The purpose of this study is to determine the effect of the national mathematics exam scores on grade point average (GPA), mathematics anxiety, and self-regulated learning of the second-year students of Mathematics Education study program, Faculty of Teacher Training and Education at Nusa Cendana University in a multivariate manner. This study is correlation research which was conducted at the Faculty of Teacher Training and Education of Nusa Cendana University. The population in this study were the mathematics education program students, Teacher Training and Education Faculty of Nusa Cendana University. The samples consist of 73 students. Data collection techniques used in this research are online questionnaires and documentation methods. Data analysis techniques used in this research are simple linear regression analysis and multivariate analysis of variance (MANOVA) and also hypothesis testing using the t-test and probability level. The result shows that (1) tvalue<ttable = 0,397<1.99394 so that there is no significant influence of the national mathematics exam scores on the students’ GPA, (2) tvalue<t table = -0.270<1.99394 so that there is no significant influence of national examination scores on mathematics anxiety, (3) tvalue<t table = 0,560<1.99394 so that there is no influence between the national math test scores on self-regulated learning, and (4) the MANOVA test shows that the GPA has a significance level of 0.693>0.05, while mathematics anxiety shows a significance level of 0.848>0.05, and self-regulated learning shows a significance level of 0.540>0.05. In conclusion, the national mathematics exam scores in a multivariate manner do not influence the GPA, mathematics anxiety, and self-regulated learning.
La percepción del riesgo en los procesos de urbanización del territorio
Authors: Vélez Jorge Andrés , Vallejo María Alejandra
Published: June 2021

La configuración  de  los  espacios  en  sus  múltiples  expresiones  es  el resultado  de  las complejas  interacciones  del  sistema  terrestre , tanto  en sus escenarios físicos como sociales. En este sentido los procesos de urb an iz ac ión del territorio son la expresión de las complejas relaciones entre el medio ambiente físico y e l hombre. El articulo aborda la proble mática de los desastres y su relac ión con lapercepción del riesg o , para ello se u tilizan dos escalas de trabajo : la ciudad de Cali y el sector de Brisas del Cauca , (Comuna N O . 7 ) evidenciando en ellas elementos en el imaginario colectivo que coadyuvan en la ocurrencia de los desastres, finalmente , se presen tan algunas  ideas qu e pueden generar procesos comunitarios de prevención.
Geopolitica del caos, orden cosmopolita ó hegemonía Norteamericana
Authors: Llano Ángel Hernando
Published: June 2021

La historia (history) aparece cada vez que ocurre un acontecimiento lo suficientemente importante para iluminar su pasado.Entonces la masa caótica de sucesos pasados emerge como un relato (story) que puede ser contado, porque tiene un comienzo y un final. Lo que el acontecimiento iluminador revela es un comienzo en el pasado que hasta aquel momento estaba oculto; a los ojos del historiador, el acontecimiento iluminador no puede sino aparecer como el final de este comienzo recientemente descubierto.
La cartografía como instrumento de comunicación en la planificación del espacio geográfico
Authors: Perea Álvarez Randy , Mayor Salazar Juan Carlos
Published: June 2021

Podría decirse que la geografía nace como ciencia por el deseo del ser humano de comprender la superficie terrestre y todos los fenómenos que la producen e interactúan en ella. Para esto la geografía se ha planteado tres cuestiones fundamentales: la primera es la topología de los hechos u objetos de un territorio; la segunda, de carácter ecológico, es la interpretación de las relaciones entre componentes inertes, vivos y humanos; y, por último, la temporalidad con la cual se conoce sobre las dinámicas que fortalecen, debilitan o cambian el espacio. Para plasmar estas ideas surge el mapa como herramienta que resume de forma concisa la realidad del espacio geográfico; esta facilidad de visualizar la superficie terrestre en una hoja de papel, en muchas oportunidades ha provocado que el mapa sea utilizado como un elemento de poder para manipular la información de los fenómenos, transformándose en un instrumento del statu quo que legitima las acciones emprendidas por el Estado. En Colombia, los mapas son utilizados para la planificación del espacio geográfico; sin embargo, dado que existe una desarticulación entre las entidades oficiales que los producen, se genera cartografía desigual de un mismo territorio, con lo cual se producen errores en la representación de la continuidad espacial de los fenómenos. Este artículo pretende reflexionar sobre el papel de la cartografía en los procesos de planificación territorial.
Movilidades cotidianas y nuevos modos de habitar: Un análisis en y desde la periferia metropolitana
Authors: Espinosa Ortiz Fabricio
Published: June 2021

La distancia cada vez mayor que separa a los habitantes de las periferias metropolitanas de las oportunidades que ofrecen los centros urbanos posiciona a la movilidad cotidiana como un importante elemento de análisis y discusión para la comprensión integral de nuevas formas de habitar la metrópoli. A partir del trabajo de campo, que consistió en entrevistas semiestructuradas, recorridos de observación, y observación par­ticipante, el presente artículo analiza experiencias de movilidad cotidiana de habitantes de la periferia metropolitana de Morelia, Michoacán, México. Se argumenta que la movilidad no se limita a los desplazamientos origen/destino, puesto que en la búsqueda de los habitantes por satisfacer sus necesidades y deseos de movilizarse se entremezclan experiencias relacionadas con sus motivos, recursos, y sentidos, que además de conformar estrategias de movilidad moldean nuevos modos de habitar.
Pesca marítima y acumulación por desposesión en Argentina (1966-2018): extranjerización del recurso, crisis socio-ambiental, precarización laboral y redistribuciones estatales
Authors: Gómez Lende Sebastián
Published: June 2021

Para el marxismo clásico, la llamada acumulación originaria o primitiva se limitó a moldear la prehistoria del sistema capitalista. Sin embargo, y dado que ese proceso continuó operando sin interrupción, el geógrafo inglés David Harvey propone redefinirlo en términos de “acumulación por desposesión”. Sobre la base de bibliografía especializada, fuentes oficiales, investigaciones independientes e información periodística, este artículo busca tender puentes entre lo teórico y lo empírico estudiando la compleja relación entre acumulación por desposesión y pesca marítima en Argentina durante el período 1966-2018. Para ello, se recurre a cuatro categorías de análisis propuestas por dicho autor: cercamiento, privatización y apropiación neocolonial imperial de recursos naturales; despojo ecológico y producción de crisis; precarización laboral y trabajo esclavo; y redistribuciones estatales. Los resultados muestran claramente que, al menos en el caso argentino, la pesca marítima debe ser considerada e interpretada como una modalidad de acumulación por derecho propio.
Acceso a la tierra y su relación con la autonomía alimentaria en el corregimiento de Bitaco municipio de La Cumbre Valle del Cauca, Colombia
Authors: Castañeda Zuluaga Lorena
Published: June 2021

La concentración de la propiedad de la tierra ha afectado en gran medida a la producción agrícola de nuestro país, tanto que las dinámicas actuales del capital económico amenazan seriamente el derecho a una alimentación adecuada. En el caso de Colombia, observamos una situación problemática en donde las comunidades campesinas están siendo despojadas de sus territorios, para ser entregados a monopolios y empresas trasnacionales. la concentración de la tierra por parte de estas empresas ocasiona múltiples contrariedades entre ellas; una notoria reducción de la tierra y extracción de los recursos naturales lo cual, impide desarrollar las diferentes actividades agrícolas productivas de las comunidades campesinas.