bluuebunny/crossref_metadata_2025 huggingface dataset:
LAZER NO INSTITUTO SÃO JOSÉ EM TEMPOS DE CELEBRAÇÕES RELIGIOSAS (CANOAS, 1908-1920)
Authors: Graebin Cleusa Maria Gomes , De Souza Francisco Eric Vale
Published: March 2023

Este estudo tem como tema, atividades de lazer realizadas por alunos do Instituto São José, fundado em Canoas, RS, em celebrações religiosas entre 1908-1920. Os problemas que orientaram a pesquisa foram: Qual a concepção que os Irmãos possuíam sobre lazer?  Por que oferecer atividades em meio às festas religiosas? Qual o tipo de lazer apresentado aos internos do Instituto São José? Partimos da premissa de que uma escola, se dá a ver tanto interna como externamente e, neste caso, por meio de festividades, mostra um grupo social em seu ambiente, afirmando-se como instituição escolar de qualidade, portanto, buscando o reconhecimento da sua eficácia e excelência. Ao problematizar a relação lazer-escola,  demonstramos que os Irmãos, para além de distender as tensões às quais os internos estavam submetidos, também ofereciam, naqueles momentos, possibilidades de formação, para além da matriz curricular. O lazer vivenciado pelos meninos, passou dos jogos diversos ao futebol, acrescentando diferentes modos de educar a sensibilidade, a partir do teatro, da música e de vivências compartilhadas também em brincadeiras e jogos coletivos.
REPRESENTAÇÃO SOCIAL DOS DIREITOS HUMANOS PRODUZIDAS POR ADOLESCENTES EM PESQUISAS NACIONAIS
Authors: Yamasaki Cecilia Yoko , Souza Rosa Cristina Ferreira de
Published: March 2023

Este artigo consiste em uma pesquisa de revisão bibliográfica entre os períodos de 2017 até 2022 sobre a representação social dos direitos humanos produzidas por adolescentes. Foram considerados os artigos de pesquisas de campo, encontradas nas bases de dados de acesso livre. Destacaram-se as relações existentes entre a atitude e comportamento dos adolescentes relacionados aos direitos humanos. Os resultados indicam que os estudantes, apesar da falta de familiaridade conceitual dos direitos humanos, sabem reconhecer ou compreender os direitos básicos, especialmente em relação ao convívio social, à estrutura e qualidade dos espaços que vivem e às reivindicações como sujeitos de direitos e protagonistas das suas próprias histórias. No que concerne aos posicionamentos e ações, os sentimentos e crenças dos adolescentes se mantém em constantes transformações, diante da necessidade de defender a vida em comum, ameaçada pelos retrocessos e violações de direitos ainda presentes. É preciso destacar que os resultados levam à reflexão da atuação profissional da psicologia como parte determinante da constituição do ser humano em relação à defesa dos direitos humanos.
“PAGO, NÃO NEGO. VIVO QUANDO PUDER”: ENDIVIDAMENTO, PRECARIZAÇÃO DA VIDA DOCENTE E GOVERNAMENTALIDADE NEOLIBERAL
Authors: Martins Evandro Sérgio Pacheco , Hennigen Inês
Published: March 2023

Apresentamos alguns resultados de uma pesquisa que teve como objetivo conhecer os efeitos subjetivos do endividamento para professoras estaduais gaúchas. Neste artigo focalizamos análises e discussões quanto à produção do endividamento das professoras e a precarização da sua vida em função da racionalidade neoliberal. A pesquisa, cuja metodologia se compôs entre uma análise de inspiração arqueogenealógica e o processo cartográfico, incluiu entrevistas com oito docentes e análise de matérias de jornais de grande circulação, do sindicato de professoras, charges e reportagens na internet sobre a temática. Aqui analisamos os impactos da governamentalidade neoliberal na condição e cotidiano das professoras considerando as políticas de austeridade conduzida pelos governos estaduais, os efeitos da dívida pública e a concepção do homo oeconomicus neoliberal, abordada por Michel Foucault. A lógica neoliberal estrutura a conduta dos sujeitos como empresários de si, com acento na concorrência e responsabilização de indivíduos. Discutimos a questão da dívida como biopolítica, as implicações do endividamento financeiro e moral das docentes e a proletarização da profissão, o que nos levou a ressaltar uma noção de precarização não só correspondente à baixa remuneração recebida pelo magistério, mas da própria vida; nestas circunstâncias, normaliza-se a (mera) sobrevivência e assegura-se o crédito para a “vivência”. Finalizamos discutimos a mutação do dito popular, que abre o título, buscando enlaçar endividamento e precarização da vida, enfoque que pensamos necessita ser mais estudado.
ESCREVENDO JOGOS EDUCACIONAIS: UMA REVISÃO BIBLIOGRÁFICA COM ABORDAGEM INSTRUCIONAL ALTERNATIVA
Authors: Mill Daniel , Andreoni Ribeiro Priscila , Veloso Braian
Published: March 2023

Este artigo trata da escrita de jogos educacionais, percorrendo os principais elementos de jogos e suas metodologias de seleção de conteúdo educacional. O objetivo principal é de refletir sobre como se escreve jogos educacionais, pela metodologia de revisão bibliográfica. As abordagens instrucionais, tradicional e alternativa, formam uma narrativa polarizada, conduzindo à reflexão sobre a melhor forma de adequar jogos educativos ao currículo. A abordagem tradicional ensina a elaboração de objetivos instrucionais antes do desenho dos jogos educacionais. A abordagem alternativa propõe um modelo baseado em contação de estórias para a seleção de conteúdo instrucional. Estórias são criadas por conflitos emocionais e de interesses, utilizar estes conflitos para criar uma narrativa de antagônicos favorece o engajamento e aprendizagem significativa.  Ferramentas técnicas adequadas empregadas na criação de jogos educacionais devem ser sempre estudadas visando à eficiência do desenho de jogos e a eficácia da aprendizagem. A principal conclusão deste trabalho é que as abordagens tradicional e alternativa não são antagônicas e ambas podem ser incorporadas na escrita de jogos digitais educacionais. Palavras-chave: Escrita de jogos educacionais; Metodologias Ativas; Jogabilidade.
ON THE ISSUE OF BELARUS' FULL MEMBERSHIP IN THE SCO: WHAT WILL CHANGE IN THE FIELD OF ALTERNATIVE ENERGY?
Authors: Pechishcheva Lyudmila A. , Shutova Anastasia A.
Published: March 2023

Aim. To study the prospects for the development of alternative and low-carbon energy in the Republic of Belarus in the context of joining the Shanghai Cooperation Organization as a full member.

Methodology. The key research methods were historical and logical analysis, comparative and typological analysis. The focus is on the study of international treaties and agreements essence, various normative legal acts, resolutions, strategies and plans for the development of cooperation, as well as statements and speeches of officials. The work also applied the scenario forecasting method to identify the promising areas for the development of “green” energy in Belarus.

Results. It is stated that with the accession of the Republic of Belarus to the SCO as a full member, a potential opportunity appeares for increasing foreign investment in projects for the development of alternative and low-carbon energy; it is expected to strengthen the energy dialogue with Russia, including the field of “green” energy; the strengthening of the position of the Republic of Belarus on the world stage is stated in connection with joining a large organization and the creation of economic and logistics joint projects.

Research implications. The study results can be relevant for studying the transformation of the energy markets of the SCO member states in the context of the global energy transition.
Restitution of fresh organic matter to the soil by woody plants in the fields of ANR in the Maradi region of central eastern Niger
Authors: Ladi Yahaya Alio Dan , Lamso Nomaou Dan , Ado Maman Nassirou , Iro Dan Guimbo , Guero Yadji
Published: March 2023

Niger, like other Sahelian countries, has experienced severe droughts that have led to the disappearance of vegetation cover in most regions and have led populations to adopt restoration techniques. This is the case of the practice of assisted natural regeneration (ANR) developed in the Maradi region. The objective of this study is therefore to quantify the fresh organic matter (FOM) of woody plants in ANR fields. The study fields were selected in two ANR terroirs (Boussaragui and Dan Saga). The direct method was used to quantify litter inputs from trees, shrubs and woody clumps that contribute to soil organic carbon stock (SOCS). Tree litter was quantified by a trap door and tussock litter by collection after clearing. The results of this work show that litterfall in the dry season occurs throughout the season, at different times depending on the terroir, with a shift in production peaks between plots in the same terroir. The average dry season litter production is 265.52 and 937.62 kg. ha-1 for Boussaragui and Dan Saga respectively. Trees and shrubs produce more litter and thus return more FOM to the soil than do tussocks. This study thus reveals that woody plants in ANR fields contribute significantly to improving the organic carbon stock of cultivated sandy soils.
Impact of E-service quality on E-loyalty with the moderating effect of E-satisfaction of youngsters using E-commerce platforms, an empirical evidence from Shopee in Vietnam
Authors: Ngoc Nguyen Bao , Yen Tran Hai
Published: March 2023

This study measures the influence of e-service quality on e-satisfaction, thereby affecting the e-loyalty of young people when shopping online on Shopee Vietnam. The purpose of this study is to provide knowledge to better understand the most important aspects of e-service quality that affect youth satisfaction, thereby affecting loyalty. This study uses qualitative research method combined with quantitative research method. The study conducted a survey on 250 users of Shopee e-commerce site. The results show that e-service quality has a significant impact on e-satisfaction in using the Shopee e-commerce platform, and satisfaction has an impact on loyalty. In which, the factor that has the greatest impact on e-satisfaction is Fulfillment.
Research of Factors Affecting the Implementation of Vietnam Public Accounting Standards at Revenue – Generating Administrative and Non – Business Units
Authors: Nhinh Nguyen Thi  , Trinh Thanh Binh , Thi Ngoc Ha Nguyen , Truc Quynh An Vu
Published: March 2023

By the method of summarizing documents, the article aims to identify the factors affecting the application of international public accounting standards in some countries, along with the views of the authors on the factors that will affect when applying Public Accounting Standards (PAS) in units within the scope of application of Accounting Standards. public mathematics in Vietnam. Vietnam is in the process of completing the development of public accounting standards through stages, in order to help the information provided on financial statements be more transparent and comparable. The factors identified through the awareness of accountants at the revenue generating public service delivery unit include: Level of training and professionalism, implementation costs, support of consulting organizations and managers and information technology application. On that basis, the article is a premise to implement an empirical research model on the influence of factors when applying public accounting standards at revenue – generating administrative and non – business units in Vietnam.
GRAFFITI TECHNIQUE DRAWING ACTIVITIES: IMPLICATIONS FOR CHILDREN'S CREATIVITY
Authors: Veryawan Veryawan , Tursina Ade
Published: March 2023

Creativity is the ability to provide new ideas that can be applied in problem solving or as the ability to see new relationships between previously existing elements. There are many types of art activities that can stimulate the development of creativity in early childhood such as: playing with plasticine or playdough, finger painting (swab blur), printing, sewing, drawing, coloring, collage, finger painting, blowing color bubbles, painting with thread pulling techniques. , drawing with grafito techniques and so forth. In early childhood the development of art can be developed through drawing activities. Drawing is a basic form of art. Drawing activities can be done with the graffito technique. This research was conducted at RA Al-Ikhlas which is located at Jl. Gg Mosque. Meliala Rantau Utara, Labuhanbatu Regency. This study consisted of 2 cycles and started from 07 to 26 October 2019. The subjects of this study were students of RA Al - Ikhlas group B, totaling 15 people consisting of 7 men and 8 women with the theme being developed was plants. . This study uses a classroom action research (CAR) model which consists of 2 cycles. Each cycle is carried out according to the themes and factors studied. The procedure of this research is planning, implementation, action and reflection. In interpreting the results of the analysis carried out during the process of drawing activities with the grafito technique, the researcher used percentage analysis to obtain results about increasing the development of creativity in early childhood through the application of drawing activities with the grafito technique and analysis tests using the average child and the criteria for mastery learning of children.
PERAN ORANG TUA DALAM MENGEMBANGKAN LITERASI PADA ANAK USIA DINI
Authors: Meilasari Devi , Diana Raden Rachmy
Published: March 2023

Pengembangan Literasi menjadi salah satu hal yang sangat penting untuk mendukung tumbuh kembang anak. Untuk itu diperlukan upaya dari lingkungan terdekat yakni orang tua dalam pendampingan anak agar memiliki kemampuan literasi yang baik. Penelitian ini bertujuan untuk mendeskripsikan peran orang tua dalam mengembangkan literasi pada anak usia dini. Penulis menggunakan jenis penelitian kualitatif dengan pendekatan deskriptif kualitatif. Subjek dalam penelitian ini adalah tiga orang tua yang memiliki anak usia empat tahun di Desa Sumberjaya. Pada penelitian ini penulis sebagai instrumen pengumpulan data dengan cara observasi, wawancara dan dokumentasi. Analisis data dimulai dari pengumpuan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa peran orang tua dalam mengembangkan literasi pada anak usia dini diantaranya orang tua membiasakan membacakan buku kepada anak, orang tua menyediakan fasilitas yang memadai, orang tua memiliki jadwal yang teratur untuk belajar maupun bermain pada anak, orang tua menciptakan lingkungan belajar yang menarik dan menyenangkan, memberikan reward sebagai wujud apresiasi kepada anak, dan orang tua harus menjadi suri tauladan bagi anak. Anak yang mendapat peranan orang tua lebih dapat memiliki peluang untuk berkembang lebih baik dalam literasi dari pada anak yang kurang mendapat peranan dari orang tuanya.
METODE CALISNA HIFAL MENINGKATKAN KEMAMPUAN MEMBACA ANAK USIA DINI DI ERA PANDEMI COVID-19
Authors: Rozi Fatlud
Published: March 2023

Children are successors on earth, every child born has various abilities. The impact of the Covid-19 pandemic has resulted in parents not optimally assisting their children in learning, especially learning to read. Reading is an important component thatmust be developed for early childhood. The need for an effective method to trigger talent, interest in early childhood development in reading and understanding their environment. For this reason, the calisna hifal method creates a leraning pattern that is interactive, active and collaborative. This study uses a descriptive qualitative research method by examining 30 children aged 0-8 years for 10 months and the results of the analysis conclude that the calisna hifal method can effectively improve early childhood reading skills in the Covid-19 pandemic era.
MANAJEMEN PEMBELAJARAN PAUD BERBASIS KEARIFAN LOKAL DALAM PERSPEKTIF FILOSOFI MERDEKA BELAJAR
Authors: Wiyani Novan Ardy
Published: March 2023

This study aims to describe and analyze the management of PAUD learning based on local wisdom in the perspective of the philosophy of independent learning at TK Diponegoro 187 Gerduren Purwojati Banyumas. This research is a type of phenomenological research with a qualitative approach. Data were collected by interview, observation and documentation techniques. Then analyzed through the stages of data reduction, data display and verification. The results showed that the management of PAUD learning based on local wisdom in the perspective of the philosophy of independent learning was processed through three stages, namely learning planning, implementation of learning and supervision of learning based on local wisdom. In these three stages, the philosophy and spirit of independent learning are actualized with the aim that children have the ability to think logically or think critically and become creative individuals as well as character. These characters are independent, responsible, creative, innovative, love the environment, and discipline. All of these characters make the child a civilized and independent person.
Research and development of combined universal cement mortar admixture
Authors:   Azerbaijan State Oil and Industry University, Suleymanov Eldar M. , Ibrahimov Rafiq S. ,   Azerbaijan State Oil and Industry University, Novruzova Sudaba ,   Azerbaijan State Oil and Industry University, Bahshaliyeva Shirin O. ,   Azerbaijan State Oil and Industry University
Published: March 2023

Due to the wide variety of drilling and cementing conditions, different grades of cements for different conditions need to be produced by factories. Nowadays, with the development of test methods and techniques, additional materials and substances, the trend has been to focus on some basic cement (base), which, with various additional substances or materials, can be modified according to the conditions of use. According to the technology adopted in Schlumberger, two portions of cement slurry are mainly used for the entire length of the annulus “lead” and “tail” i.e. literally the “leader” (the first portion) and the “tail’ (the second, last portion). Of course, the treatment of these portions with chemical reagents is different, and the first portion is several times larger in volume than the second portion. It is known that as a result of unsuccessful cementing, a gas-water-oil show may appear, leading to the removal of casing strings, fire, etc. As a result, this leads to the abandonment of the well. There is a time difference between the mixing of the first and subsequent portions of dry cement, especially the last ones, since while the subsequent portions of dry cement are just being mixed, the freshest ones have not yet been mixed at all, but the first portions are already finished; this portion of cement slurry in the well gradually begins to thicken under the influence of temperature and pressure. An effective reagent is needed. The optimal composition of the combined reagent should be considered as follows: CMC – 0.2%; FLS – 0.4%; Na2CO3 – 0.05%.
Effect of Non-genetic Factors on Growth and Production Traits in Two Strains of Japanese Quails
Authors: Sharma Shubhankar , Sahoo Saroj Kumar , Dash Shakti Kant , Dubey Prem Prakash
Published: March 2023

Background: The growth of birds is a function of both genetics and environment involving change leading into improvement in weight, shape, size, volume, etc. Study of important non-genetic factors is important in view of formulating future selection and breeding strategies in different poultry species. Methods: The present study was done on 1246 numbers of Japanese Quails (Coturnix coturnix japonica) of two strains i.e., black and white distributed in three generations during 2020-21. The fixed effects of gender, season of hatch, strain and generations on various fortnightly body weights (FNBW), average daily weight gain (ADWG), relative growth rate (RGR) and some production traits were studied. Result: Significant (p≤0.01) differences in black and white strain as well as male and female quails for hatch weights were observed. The maximum ADG was during 4th to 6th wk whereas the RGR was highest during first fortnight (hatch-2nd wk). Significantly (p≤0.01) higher average egg weights (AEW) were observed in white quails. Part egg production (PEP) and AEWs were higher during summer and winter hatches, respectively. The present investigation elucidates the significance of different non-genetic factors on important growth and production performances for further selection in quails.
Dinámicas urbanas de conmemoración y resistencia. Memoriales anti-monumentales en Chile pos rebelión de octubre de 2019
Authors: Pérez González Patricio Octavio
Published: March 2023

La estética de los memoriales adscritos a la hegemonía política en Chile, se ha desarrollado relevando principalmente las grandes hazañas y los nombres magnánimos del relato histórico dominante. Por su parte, la estética de las resistencias políticas sugieren, en contextos de protesta social y represión, el levantamiento de las figuras de los vencidos, nombres olvidados, mujeres y personajes excluidos del relato de la memoria tradicional. A partir del estudio de la urbe, entendida como espacio fronterizo, donde se tensionan los relatos de las memorias hegemónicas y resistentes, este trabajo propone una discusión teórica y empírica de la estética anti-monumental, aplicada al memorial erigido en Santiago de Chile en homenaje a Mauricio Fredes, que se manifiesta como el texto que subvierte los sentidos de la conmemoración, desde la insurgencia. Asimismo, este trabajo ofrece una lectura, desde la perspectiva de la historia del tiempo presente, de las condiciones políticas, económicas y sociales que sientan las bases de la ola de protestas desarrolladas en Chile en octubre de 2019, que dan como resultado la muerte de Fredes, entre otras personas, a quien la estética de las memorias de resistencia conmemora.
Editorial. Procesos de turistificación y gentrificación en América Latina y España: una panorámica
Authors: Moriente David , Botella Ordinas Eva
Published: March 2023

Editorial. Procesos de turistificación y gentrificación en América Latina y España: una panorámica
KÜRESEL RİSK ALGISININ CARRY TRADE BELİRLEYİCİLERİ ÜZERİNE ETKİLERİ: TÜRKİYE, İNGİLTERE, ABD ÖRNEKLERİ
Authors: ERER Deniz , GACENER ATIŞ Aydanur
Published: March 2023

Bu çalışmanın amacı, Türkiye, İngiltere ve ABD’de carry trade faaliyetinin temel belirleyicilerini küresel risk algısının yüksek ve düşük olduğu dönemler açısından analiz etmektir. TVAR modelinden elde edilen sonuçlara göre, faiz oranları farkının küresel risk algısının gerek yüksek gerekse düşük olduğu dönemlerde carry trade faaliyetinin arkasındaki temel unsur olduğu görülmüştür. Döviz kuru belirsizliği, küresel risk algısının yüksek olduğu dönemde Türkiye ve İngiltere’de carry trade faaliyetinden vazgeçilmesine neden olan bir unsurken, küresel risk algının düşük olduğu dönemde anlamlı bir etkisinin olmadığı, ABD’de ise döviz kuru oynaklığındaki artışa rağmen yatırımcıların carry trade faaliyetlerini gerçekleştirmeye devam ettiği tespit edilmiştir.
Yeni Sanayileşen Ülkelerde Çevresel Kuznets Eğrisi Yaklaşımının Geçerliliği: 1980-2020 Dönemi
Authors: KOPUK Ezgi
Published: March 2023

Çalışmada rekabet avantajı elde etmek için yüksek çıktıya ihtiyaç duyan yeni sanayileşen ülkelerin çevreci politikalarını dikkate alarak ekonomik gelişimlerini sağlayıp sağlamadığını Çevresel Kuznets Eğrisi Hipotezi altında belirlemek amaçlanmıştır. Bu amaç kapsamında 1980-2020 yılları için hipotez, panel veri analizi ile test edilmiştir. Çalışmada yatay kesit bağımlılığını dikkate alan CADF birim kök, Westerlund eşbütünleşme ve Geliştirilmiş Ortalama Grup Tahmin Edici (AMG) testleri kullanılmıştır. Edinilen bulgulara göre değişkenler arasında uzun dönemli bir ilişkinin olduğu gözlemlenmekle birlikte, Meksika, Brezilya, Endonezya, Filipinler, Hindistan, Malezya ve Tayland’ da kişi başı gelirdeki artışın karbon emisyonlarını artırdığı tespit edilmiştir. Sonuç, gelişimlerini henüz tamamlamamış olan yeni sanayileşen ülkelerde beklentiler yönünde gerçekleşmiş olup, kişi başı gelirdeki artışın sanayileşme sürecinde çevresel sorunları artırdığını ileri süren çevresel Kuznets eğrisi hipotezinin geçerliliğini göstermektedir. Aynı zamanda ekonomik büyümedeki artışa bağlı olarak CO2 emisyonundaki yüzdesel artış oranlarına bakıldığında, ülkelerin çevresel Kuznets eğrisinde zirve noktasına yakın bir seviyede yer aldığı ifade edilebilir.
CLINICAL CASE OF OSTEOSYNTHESIS FOR HUMERAL NECK IN A PATIENT WITH OSTEOPOROSIS
Authors: KOLOBOVA EKATERINA A. , PEREGORODOV ALEXEY N. , GRISHIN ALEKSEY V.
Published: March 2023

Fractures of the proximal humerus are among the most common, especially among patients of older age groups. Often these fractures require surgical treatment. However, comminuted fracture, osteoporosis make it difficult to carry out osteosynthesis. This article describes a clinical case of successful treatment of a fracture of the surgical neck of the humerus in a patient with osteoporosis. Surgical intervention was carried out on the basis of the developed method of osteosynthesis of a fracture of the surgical neck of the humerus (RF Patent no. RU 2749296 C1). To fix the fragments we used a T-shaped plate, screws and a wire loop-tie passed through the head of the humerus. Carrying out the metal structure extramedullarly through the fracture line minimizes additional intraoperative damage and creates a reliable fixation of fragments without the risk of loosening and migration of the metal structure, which allows this method to be used in the osteoporotic process in the head of the humerus. Obtained results of the patient's treatment are good: restored function and amplitude of movement in the shoulder joint, no pain syndrome. The presented clinical case demonstrates the expediency and effectiveness of osteosynthesis according to our proposed method for fractures of the proximal humerus on the background of osteoporosis.
FORMATION FEATURES OF NONSPECIFIC PATHOMORPHOLOGICAL CHANGES IN KIDNEY TISSUE DURING TUMOR PROCESSES (EXPERIMENTAL STUDY)
Authors: SUBBOTINA TATIANA I. , PITIN PAVEL A.
Published: March 2023

The study is relevant due to an increase of oncological diseases and its complications from tumor growth or treatment. Research purpose : to study in an experiment the formation of pathomorphological changes in kidney tissue, taking into account the development of the tumor process and cytostatic therapy. Research objectives : to study morphological changes in the kidneys caused by the tumor process in an animal experiment; to study the effect of methotrexate on the dynamics of pathomorphological changes in the kidneys; to identify of the severity of pathomorphological changes in experimental groups. Materials and methods . We conduct the study on Balb/c mice according to the recommendations set out by the Ministry of Health of the USSR no. 755 and the Helsinki Declaration. Euthanasia was performed by administration of sodium thiopental. The control group was represented by mice without formed tumors. Experimental groups were formed from animals with tumors. Pathomorphological changes in the kidneys were studied both without the administration of methotrexate and with the use of methotrexate. Cytostatic was administered in a dosage of 0.2 mg. Pathomorphological studies of tumors and kidneys were carried out according to the standard histological technique. Results . In experimental groups of animals with a tumor process, nonspecific pathomorphological changes prevailed in the form of irreversible necrobiotic and microcirculatory changes in both cortical and cerebral sections of nephrons, while fibroplastic and microcirculatory changes prevailed when methotrexate was administered. Conclusion . The severity of pathomorphological changes in the kidneys depended on the presence of a tumor process and the effects of methotrexate.
Contraceção Reversível de Longa Duração na Adolescência: A Realidade de um Hospital Pediátrico Terciário em Portugal
Authors: Ferro Beatriz , Simões Mafalda , Gomes Bárbara , Rodrigues Ângela , Geraldes Fernanda , Águas Fernanda
Published: March 2023

Introdução: A contraceção na adolescência tem um papel fundamental na sociedade por prevenir gravidezes indesejadas e infeções sexualmente transmissíveis. O uso de métodos contracetivos reversíveis de longa duração (LARCs) tem vindo a ser recomendado pela sua eficácia e perfil de segurança nesta faixa etária. O objetivo deste estudo foi avaliar a utilização de LARCs na população de uma consulta de Ginecologia da Infância e Adolescência e descrever as características sociodemográficas das adolescentes assim como a prática contracetiva prévia.Material e Métodos: Análise retrospetiva que incluiu as adolescentes utilizadoras de LARCs, acompanhadas na consulta de Ginecologia da Infância e Adolescência de um hospital pediátrico terciário português, no período entre junho de 2012 e junho de 2021.Resultados: Foram incluídas 122 adolescentes, cuja mediana de idades foi 16 (11 – 18) anos. Destas, 62,3% (n = 76) eram sexualmente ativas. O método preferencial foi o implante subcutâneo, colocado em 82,3% (n = 101), seguido do sistema intrauterino de Levonorgestrel (SIU-LNG) em 16,4% (n = 20) e o dispositivo intrauterino de cobre em 1,3% (n = 1). As principais indicações para a escolha de LARCs foram desejo contracetivo em 90,2% (n = 110), hemorragia uterina anormal da puberdade em 14,8% (n = 18), dismenorreia em 10,7% (n = 13) e necessidade de amenorreia em 0,8% (n = 1). O tempo mediano de utilização do implante foi 20 (1 – 48) meses e do SIU-LNG 20 (1 – 36) meses. A taxa de continuidade aos 12 meses para ambos foi de 76,2% (n = 93). A taxa de remoção antes do tempo padronizado foi de 9,8% (n = 12) nas adolescentes que colocaram implante, sendo que não foram removidos SIU-LNG ou dispositivo intrauterino de cobre. Não se registaram gravidezes após a colocação de LARCs.Conclusão: O desejo contracetivo foi o primeiro motivo para a escolha de um LARC seguido do controlo da hemorragia uterina anormal e da dismenorreia. Todos estes fatores poderão contribuir para a elevada taxa de satisfação e continuidade destes métodos.
Neurological complications of COVID-19 and SARS-CoV-2 vaccination: an update
Authors: Meng Huanyu , Zhou Qinming , Chen Sheng
Published: March 2023

The respiratory infectious disease COVID-19, which emerged in 2019, has affected the world population over a brief period. In 2020, the disease was declared a pandemic by the World Health Organization. Although most COVID-19 patients primarily develop respiratory symptoms, neurological symptoms have been observed. Neurological symptoms are usually mild and non-specific. However, some patients could experience life-threatening neurological symptoms. With the increase in the incidence of COVID-19, the disease spectrum of patients with central and peripheral nervous system involvement has expanded significantly compared to the previous period. Lack of awareness has caused delays in diagnosis and treatment; therefore, updating the disease spectrum of neurological complications of COVID-19 is necessary. After COVID-19 claimed millions of lives, researchers found that some vaccines may induce autoimmune inflammatory responses in the nervous system via molecular mimicry, leading to SARS-CoV-2 vaccine-related neurological deficits. These neurological complications are often ignored by clinicians, delaying diagnosis and treatment; it is essential to study cases of vaccine-associated neurological complications. Therefore, we summarize the neurological complications of COVID-19 and nervous system adverse reactions caused by SARS-CoV-2 vaccines to help clinicians and public health service personnel understand these rare complications. Avoiding delays in diagnosis and treatment would ensure the safety of COVID-19 patients and SARS-CoV-2 vaccine recipients.
Bioinformatics Analyzes of Selectins Polymorphisms Reveal New Potential Cancer Biomarkers
Authors: Rabi Larissa Teodoro , Valente Davi Zanoni , Teixeira Elisangela de Souza , Peres Karina Colombera , Bufalo Natassia Elena , Ward Laura Sterian
Published: March 2023

Selectins are responsible for the early stages of cell migration as they control cell adhesion. They make the microenvironment permissive for metastatic events by promoting the activation of other cell adhesion molecules (CAMs). We employed several robust bioinformatics tools to evaluate gene sequence; single nucleotide polymorphisms (SNPs) in intronic and UTR regions; and missense SNPs with amino acid change in L-selectin (SELL), E-selectin (SELE), P-selectin (SELP) and PSGL-1 (SELPLG). We demonstrated that gene polymorphisms rs2229569, rs1131498, rs4987360, rs4987301 and rs2205849; polymorphisms rs3917777, rs2205894 and rs2205893 of SELP gene; rs7138370, rs7300972 and rs2228315 variants of SELPLG gene; and rs1534904 and rs5368 polymorphisms of SELE gene may produce important alterations in the DNA structure and consequent alterations in the morphology and function of the corresponding proteins. These Selectin polymorphic variants deserve further investigation in cancer patients, as they may become useful clinical markers for risk determination, diagnostic and prognostic biomarkers or even targets for targeted therapies.
Developing a Supplementary Diagnostic Tool for Breast Cancer Risk Estimation Using Ensemble Transfer Learning
Authors: Hanis Tengku Muhammad , Ruhaiyem Nur Intan Raihana , Arifin Wan Nor , Haron Juhara , Wan Abdul Rahman Wan Faiziah , Abdullah Rosni , Musa Kamarul Imran
Published: March 2023

This study utilised an ensemble of pre-trained networks and digital mammograms to develop a supplementary diagnostic tool for radiologists. Digital mammograms and their associated information were collected from the department of radiology and pathology, Hospital Universiti Sains Malaysia. Thirteen pre-trained networks were selected and explored in this study. ResNet101V2 and ResNet152 had the highest mean PR-AUC, MobileNetV3Small and ResNet152 had the highest mean precision, ResNet101 had the highest mean F1 score, and ResNet152 and ResNet152V2 had the highest mean Youden J index. Subsequently, three ensemble models were developed using the top three pre-trained networks based on PR-AUC, precision, and F1 score. The final ensemble model had a mean precision, F1 score, and Youden J index of 0.82, 0.68, and 0.12, respectively. Additionally, the final model demonstrated a balanced performance across mammographic density. In conclusion, this study exhibited the good performance of the ensemble transfer learning on digital mammograms for the purpose of breast cancer risk estimation. This model can be utilised as a supplementary diagnostic tool for radiologists, thus, reducing their workloads.
Crash Risk Modelling and Analysis of Drone Operation inIndonesia’s Outermost and Underdeveloped Areas using Bayesian Network Approach
Authors: Indriyanto Toto , Fathurrahman Aziz , Rawikara Seno Sahisnu , Jenie Yazdi Ibrahim , Arifianto Ony , Sasongko Rianto Adhy
Published: March 2023

Limited accessibility in some parts of Indonesia causes difficulties in logistic distribution, especially for emergency and medical supplies. Emerging drone cargo technology is a potential solution to improve logistic distribution in those areas. However, implementing drone cargo technology involves unknown risks, both in technical and non-technical aspects. Since data on drone operations in Indonesia is limited, a new method is explored to build a Bayesian Network (BN) model for risk analysis of drone crashes in Indonesia’s outermost and underdeveloped areas. The method optimizes the modelling process, in which significant risk factors are selected based on three drone operator companies’ experiences, which include wind speed, rain intensity, and system component failure or malfunction. Real wind speed and rain probability data are then implemented in the model. The operator’s data shows that wind speed contributes to drone crashes, which can be appropriately modelled in the BN model. The model produced a probability of safe operation of 94.1%, comparable to the annual operator’s data. The result shows that most operations are safe, with a minimum case of crashing and no case of harming human life.
Application of Variational AutoEncoder (VAE) Model and Image Processing Approaches in Game Design
Authors: Mak Hugo Wai Leung , Han Runze , Yin Hoover H.F.
Published: March 2023

In recent decades, the Variational AutoEncoder (VAE) model has shown good potential and capabilities in image generation and dimensionality reduction. The combination of VAE and various machine learning frameworks has also worked effectively in different daily life applications, however its possibility and effectiveness in modern game design has seldom been explored nor assessed. The use of its feature extractor for data clustering was minimally discussed in literature neither. This paper first attempts to explore different mathematical properties of the VAE model, in particular, the theoretical framework of the encoding and decoding processes, the possible achievable lower bound and loss functions of different applications; then applies the established VAE model into generating new game levels within two well-known game settings; as well as validating the effectiveness of its data clustering mechanism with the aid of the Modified National Institute of Standards and Technology (MNIST) database. Respective statistical metrics and assessments were also utilized for evaluating the performance of the proposed VAE model in aforementioned case studies. Based on the statistical and spatial results, several potential drawbacks and future enhancement of the established model were outlined, with the aim of maximizing the strengths and advantages of VAE for future game design tasks and relevant industrial missions.
The Impact of Ultraviolet Radiation on Energy Metabolism and Metabolic Disorders in Mice: Mechanisms and Implications
Authors: Quan Qing-Ling , Yoon Kyeong-No , Lee Ji Su , Kim Eun Ju , Lee Dong Hun
Published: March 2023

Ultraviolet (UV) radiation has both harmful and beneficial effects on human health. It can cause skin damage and cancer, but also provides the primary source of vitamin D. Additionally, UV radiation affects energy metabolism in mice with metabolic diseases and has protective effects on hypertension and cardiovascular diseases.Metabolic Syndrome is a collection of metabolic dysfunctions such as dyslipidemia, hypertension, hyperglycemia, abdominal/central obesity, and insulin resistance. Chronic UVR exposure suppressed obesity and type 2 diabetes in high-fat diet-fed mice, while vitamin D supplementation did not replicate these effects. On the other hand, topical application of nitric oxide (NO) donors replicated UV effects on mice, and NO scavengers prevented the positive impact of UV. UVR may prevent the development of obesity and metabolic syndrome through mechanisms that depend on UVR-induced NO, not vitamin D. Exposure to sunshine has a protective impact on blood pressure and cardiovascular disease. Although lower vitamin D concentration is linked to increased hypertension and the incidence of CVD, oral vitamin D supplementation does not decrease blood pressure or the risk of CVD, indicating that vitamin D may not mediate the beneficial effects of sun exposure. Instead, NO plays a crucial role as an endogenous vasodilator, produced by the vascular endothelium. Solar UVA may release nitrogen oxides from skin storage into the bloodstream, lowering blood pressure and cardiovascular mortality.In conclusion, UVR exposure could be a promising non-pharmacological intervention for metabolic syndrome, hypertension, and CVD prevention, and NO may play a crucial role in mediating these effects. Further research is needed to explore the precise mechanisms and identify the optimal doses and exposure times of UVR.
Pregnancy Card: Evaluation of Data on Vaccines for Women in Labor in a Public Tertiary Reference Maternity Unit in São Paulo, Brazil
Authors: Gilberti Panucci Luís Antônio , Sant’anna Pinheiro Luiza , E. Prestes-Carneiro Luiz
Published: March 2023

There is a lack of information on vaccination for pregnant women in the Brazilian literature. Our aim was to evaluate the data on vaccines recorded on the pregnancy card and knowledge about the importance of vaccination for women admitted for labor in a reference public tertiary maternity unit in Presidente Prudente, São Paulo, Brazil. Vaccine data as prescribed by the National Immunization Program of Brazil (NIP) in prenatal cards for patients in labor from the 45 municipalities of the western region of São Paulo state were obtained. A questionnaire relating to knowledge about the types and importance of vaccination in pregnancy was applied. All vaccines indicated by the NIP were registered in only 12.0% of the prenatal cards, and 33.0% of cards registered any vaccines. In this group, 16.6% were aged between 14 and 21 years, and tetanus and COVID-19 were the most prevalent vaccines that they had heard of during prenatal care. Data on vaccines was poorly recorded in the cards, suggesting a lack of attention and unpreparedness of professionals working in primary care. Our study has countrywide and global relevance, and may be applied mainly in Latin American countries facing similar difficulties and limitations with low rates of vaccination during pregnancy.
Optimizing the CO2 emission of composite steel‐concrete beams with external prestressing
Authors: Fiorotti Kamila Madeira , Calenzani Adenílcia Fernanda Grobério , Alves Elcio Cassimiro
Published: March 2023

The literature has well established prestressing in concrete beams and its calculation procedures. However, its use in composite steel-concrete beams has increased despite main normative codes lacking a specific approach for it. Designers must, in most cases, combine the available criteria to calculate the standards of steel and reinforced concrete structures. This study aimed to formulate this optimization problem and analyze CO2 emissions for the optimal design of composite steel-concrete beams with external prestressing. The design variables for the optimization problem include cross-section of laminated or welded profiles, slab height, characteristic strength of concrete to compression, and number of tendons. We obtained a solution for the optimization problem via a genetic algorithm (GA) and a particle swarm optimization one (PSO). Comparative analysis with experimental example and with optimization problem of prestressed steel beam are performed. An parametric analysis to several spams is performed, which enabled to evaluate the factors that most impact CO2 emissions. According to results, the chosen algorithms effectively obtained solutions for the problem, and PSO usually provided better results than GA. Regarding the final solution composition, steel contributes the most to emissions, welded profiles provided better solutions than laminated ones, and laminated spans of up to 17.5m and welded ones up to 27.5m dispensed with tendons.
WORLDVIEW FOUNDATIONS OF PALEOASTRONOMY OF EUROPEAN NEOLITHIC AND BRONZE AGE CULTURE
Authors: Tararoev Jakov
Published: March 2023

In the article the considered problem of world view principles of culture of the European neolith and bronze age. Described and analyses material artefacts that touch paleoastronomy, id est constrained to those or by another character with astronomic supervisions, or somehow represented the objects of supervision and aim, what it was done for. The analysis of all artefacts specifies on that the basic object of supervision was a Sun and special points him annual motion: vernal and autumn equinox, winter and summer solstice. Taking into account the features of climate in Europe, namely large seasonal vibrations, large difference of winter from a summer and impossibility during a winter to engage in growing of plants, and all of it is related to position of a Sun on sky, in the article a hypothesis is pulled out that the world view of representatives of this culture, that functioned within the framework of religion, carried cosmocentric character there was a Sun in the center of that, and Echo executed the auxiliary functions of account of motion are certain Sun. Taking into account common property of the first, and further religions that gave it a shoot to decide the problem of human death and immortality, and leaning on the considered artefacts, it is possible with the high fate of authenticity to talk that cult a Sun was not carried by anthropomorphous character, id est a Sun not personified in a man. The representatives of this culture worshiped to a Sun as natural phenomenon in a that kind, in that they perceived him sense-organs directly. It is related to that forces of nature, unlike cultures, that were more south, were more mighty, what forces of organization of human society. In more south cultures organization of society influenced on growing of plants and organizational capabilities acquired sacral maintenance in the persons of Gods and heroes. The end of this culture, for certain, is bound by a crisis and death of the world system of bronze age, where this culture was integrated.
CRITIQUE OF THE SENSE IN W. V. O. QUINE’S PHILOSOPHY
Authors: Hlushchenko Eugene
Published: March 2023

The article is devoted to the studies the problems of interpretations and representations of the concept of “sense” in logical semantics , which has been analyzed by the outstanding American philosopher and mathematician of the middle and a second half of the XX century – Willard Van Orman Quine, who has snooped far enough into the presented problem in numerous of his works, mainly, his “Word and Object” and “From a Logical Point of View”. The central critical theories of understanding Quine’s thought of the sense is seen at another angle, that is, as a main concept that gets some responds of the philosophers in post-analytical philosophy tradition, along with it is reviewed as a broadly interpreted concept. Additionally, modes of such critique can be found as in some classic works of the philosophers like D. Davidson or M. Dummett, or as of such modern analytical philosophers as: M. Baghramian, L. Komacha, P. Livingston, J. Smith, and others.

About this material few modern works and Quine's as well have been particularly researched, and of our opinion, the movement of such explanation of the sense problem in  Quine's works keeps coming to be emphasized in today's philosophy. We result this work on that the critique of the sense in Quine's works hadn't been done the way perfectly: not enough enlightened though. Hereby we claim to keep monitoring and not to stop studying of the metaphysical context of works and cultural as well. The better that point becomes to get larger area to study the more successful the research is expected.

That way of criticizing half-metaphysical concepts aimed as a method, on the one hand, is required for a more advanced investigations of the proliferation in post-analytical philosophy works, and, on the other hand, as a reason of ideas and views separation, which are not relevant to the traditional analytic philosophy, is taken and viewed using examples. New critique of few aspects of Quine's philosophy are necessary to get closer to the as the philosopher's ideas to the newest ideas for the development of the science as well. Many key and well points can be gotten from the way to analyze the works. Interpretations of meaning of the concept of sense in the different papers of analytical philosophers is supposed to change the key direction of the considered this topic.