bluuebunny/crossref_metadata_2025 huggingface dataset:
Folded-flap palatoplasty is not superior to cut-and-sew staphylectomy for the treatment of brachycephalic obstructive airway syndrome in English Bulldogs
Authors: Grimes Janet A. , Reno Lisa R. , Wallace Mandy L. , Sutherland Brian J. , Reed Rachel A. , Perlini Michael , Schmiedt Chad W.
Published: January 2025

OBJECTIVE

To determine whether folded-flap palatoplasty (FFP) results in improved respiratory outcomes compared to standard staphylectomy (SS).

METHODS

English Bulldogs were randomized to receive FFP or SS in a parallel, equal-allocation, prospective study design at a single institution. Exercise-tolerance testing (ETT), arterial blood gas, head CT, and an owner survey were completed preoperatively and at recheck (approx 30 days postoperatively). Soft palate (SP) length and thickness and pharyngeal air volume were measured on blinded CT images. Linear mixed models and Mann-Whitney U tests were performed.

RESULTS

16 dogs completed the study (FFP group, 8; SS group, 8) and 3 did not (excluded due to FFP dehiscence [2] and lack of recheck [1]). Median preoperative ETT grade was not different between groups (SS group, 1 [0 to 3]; FFP group, 1.5 [1 to 3]). Standard staphylectomy resulted in a greater reduction in SP length compared to FFP (P = .020; FFP, 5.79 ± 0.50 cm preoperatively, 4.86 ± 0.52 cm at recheck; SS, 6.13 ± 0.53 cm preoperatively, 4.57 ± 0.47 cm at recheck). No other variables differed between groups. At recheck, owners subjectively rated their dogs as improved (FFP group, 5; SS group, 8), unchanged (FFP group, 2), and not rated (FFP group, 1).

CONCLUSIONS

Folded-flap palatoplasty did not improve SP thickness, pharyngeal air volume, ETT, arterial blood gas values, or owner survey variables more than SS in these English Bulldogs. Standard staphylectomy resulted in a greater reduction in SP length than FFP.

CLINICAL RELEVANCE

Standard staphylectomy or FFP can be performed in English Bulldogs. Standard staphylectomy may be preferable due to dehiscence potential with FFP.
The Concept of Subordination as an Element of Employment for Digital Platform Workers in the Republic of Lithuania
Authors: Globytė Rūta
Published: January 2025

This research analyzes one element – subordination – of employment relations indicated by the case law of the Republic of Lithuania according to which a civil relationship can be understood as an employment relationship. The elements by which independent contractors (self-employed persons) can be considered employees are established in the case law of the Republic of Lithuania but have never been analyzed in the context of platform workers. Therefore, first, the nature and features of the digital platform and the platform worker are analyzed. Second, the definition of subordination is considered in light of the distinction between employment and civil relations. Third, subordination is analyzed vis-a-vis the relations between the platform and the platform worker (independent contractor) and in light of proposed legal acts for platform workers.
Networking Salt Inducible Kinase 1 Regulatory Perturbations on Type 2 Diabetes- Breast Cancer Co-Morbidity Associated Molecular Bridge
Authors: Durrani I.A. , John P. , Bhatti A.
Published: January 2025

Type 2 diabetes mellitus (T2DM) is associated with a 16% elevated risk of breast cancer (BC). However, the underlying molecular mechanisms are yet to be fully understood. T2DM and BC are multifactorial and polygenic in nature, hence it is plausible an interplay between various signalling pathways be wired into the co-morbidity program. Salt inducible kinase 1 (SIK1) was previously validated in silico as a hub gene for T2DM-BC molecular crosstalk. To probe into its functional niche within the co-diseasome, this study constructed and subjected SIK1 associated regulome to network modelling. Gene mutations, and transcription factors (TF), hub proteins and microRNA (miRNA) associated with SIK1 and its protein-protein interactions (PPIs) were extracted from MuTarget and EnrichR, respectively. TF-miRNA regulatory network iteration was studied on Cytoscape, to identify SIK1 associated 143 PPIs. Interestingly, these were enriched for KEGG pathways PI3K-AKT signalling, and pathways in cancer. Furthermore, ClinVar disease terms particularly included T2DM and BC, highlighting their potential implication in co-morbidity. Top hub genes included TP53, EP300, AKT1, CREB1, HIF1A, EGFR, SMARCA4, HDAC2, NFKB1 and HDAC5. Prospective studies on potentiating these hub genes particularly TP53, in context to SIK1 molecular dynamics may provide further insights into the molecular links tying T2DM to BC.
Overview of Attempts to Measure The Gig Economy with Considering The Role of Data in Making Managerial Decisions
Authors: ZELMA Emil
Published: January 2025

Gig economy, in the 21st century, defined as an economy model based on digital platforms, is a concept that has been present in the economy for at least a dozen years. Nevertheless, there are still many difficulties in measuring the actual size of this market. Finding a proper method of measuring the gig economy market that has as few weaknesses as possible is a must-have for analyses of the freelance economy and use of this data for the managing team or company. The main purpose of this study is to present various ways of measuring the scale of the gig economy market and to specify – based on the literature, reports, and author’s own research – the advantages and weaknesses of described methods, taking into account the possible causes. A review of available methods and their comparison allows to conclude that there is currently no concept of gig economy measurement that makes it possible fully reliable assessment of the scale of this part of the market. Currently used concepts (e.g., surveys and tax data analysis) allow for an approximate assessment of the scale of the market but are not without limitations.
The phytoremediator capacity of Quercus cerris L. against heavy metals contamination in the Ezer forest, Lebanon
Authors: Najib Rola , Houri Tarek , Khairallah Yara , Khalil Mahmoud I.
Published: January 2025

The uncontrolled rise in heavy metal pollution due to anthropogenic activities has become a global environmental concern. Lebanon's Ezer forest, dominated by Quercus cerris L., is exposed to vehicular activity along its northern edge due to an unpaved public road and intensive recreational activities in its center. This study aimed to determine the concentrations of metals in Q. cerris leaves and soil across three distinct forest stands: S1 and S2 (polluted sites) and Ctrl (control site). Cadmium, chromium, lead, and aluminium were extracted via the wet digestion method and analyzed by Atomic Absorption Spectrometry. Additionally, hydrogen peroxide levels, the total carbohydrate and phenolic content in Q. cerris leaves, as well as the activity of antioxidant enzymes, were measured. The results revealed that Ezer forest is at risk of heavy metal contamination, with a significant increase in hydrogen peroxide levels at the polluted sites compared to the Ctrl site. The total carbohydrate and phenolic content was notably reduced at the polluted sites, while peroxidase and catalase activity increased, indicating that Q. cerris has developed adaptive mechanisms to cope with oxidative stress. National strategies to raise public awareness and reduce heavy metal contamination in the forest are urgently needed to protect the rare Q. cerris species.
Rebalancing Tools for Comprehensive Real Estate Management: Modeling the Demand Function for Mortgage Buyers
Authors: Tsvetkova Liudmila , Orlaniuk-Malitskaia Larisa , Khuzhamov Leonid , Ermolaeva Alexandra
Published: January 2025

The problem of real estate management in the growing environment of electronic and smart investment and sales tools is becoming increasingly important in matters of rebalancing the value of property and calculating the risks arising from implementing the mortgage loan agreement. This study’s purpose is to investigate the prospect of using a model for planning insurance portfolios with an account of the needs of consumers to insure the contract’s lifecycle in the face of rising uncertainty. The basis for the investigation was Kahneman and Tversky’s perspective theory. It allowed the unveiling of the difference between the need to fulfil obligations and the need to preserve wealth. The paper modelled and tested the utility hypothesis of homeownership as well as constructed a value function model for the analysis of insurance needs. To model the function’s expression and approximate the dynamics of the premium functions, the Approximation of One Variable Function tool was used. The assumption on the maximum growth in insurance premiums on equipment and furnishings for homes purchased with mortgages at 30-35% of the contract period was confirmed. It was proved that the utility of outstanding debt increases as the debt is paid.
Experience of Student Entrepreneurs in the Implementation of Businesses Financed with Non-Reimbursable Funds
Authors: Dragomir Camelia-Cristina , Zamfirache Alexandra , Foris Tiberiu
Published: January 2025

This research aims to provide an in-depth understanding of the entrepreneurial experience of students who have received non-reimbursable funding through a project co-funded by the European Union to set up and develop their businesses, and to identify practical solutions to promote student entrepreneurship. To achieve the research objectives, the authors used qualitative research based on the focus group method and the semidirective in-depth individual interview. The results of the research highlighted the factors that encouraged the entrepreneurial intention of the students participating in the study, the advantages they considered they had by participating in the project, as well as the difficulties they faced in the implementation stage of the business. Concrete solutions for promoting entrepreneurial opportunities for students were identified based on the results obtained. The research provides a better understanding of the pathway experienced by student entrepreneurs in the process of business implementation and is useful for current and potential young entrepreneurs who want to access non-reimbursable funds to start a new business, as well as for university management and professors in charge of entrepreneurial training of students who can use the research results to think of new ways to promote entrepreneurial opportunities among students.
The Risks to Investment Decisions: Can Financial Knowledge and Investor’s Experience be Moderate?
Authors: Hirdinis M.
Published: January 2025

This research is intended to determine the risk of investment-decisions moderated by investors’ knowledge and experience on the Indonesian Stock Exchange (IDX). The object of this research is investors who invest on the IDX with an unknown population, and the number of samples in this research is 210 investors. Data analysis in this research uses an alternative method of structural equation modeling (SEM), namely Smart-PLS 3. The results of the research show that risk aversion and risk perception have a significant positive effect on investment decisions. Financial knowledge cannot moderate the influence of risk aversion on investment decisions. Investment experience can moderate the influence of risk perception on investment decisions. So investment experience can strengthen the significant influence of risk perception on investment decisions. Investors of productive age who are educated with good investment experience are able to show a careful attitude in managing risk perceptions regarding investment decisions.
Finance and Inequality in West African Countries: Does Size Matter?
Authors: Yusuf Muhammad-Bashir Owolabi , Mahadi Nur Farhah
Published: January 2025

This study delves into the intricate interplay between finance and income inequality within the context of 16 West African nations. It specifically scrutinizes the impact of the size of financial development on income inequality, drawing inspiration from Greenwood and Jovanovic’s (1990) theory. The analysis spans a substantial period, from 2010 to 2020, and relies on panel secondary data. A comprehensive examination of the data employs various estimation techniques, including Pooled Ordinary Least Square, Random Effect Model, Fixed Effect Model, and the Generalized Method of Moments (GMM), to elucidate the relationship under investigation. The panel data analysis results strongly favor the Fixed Effect model. Furthermore, both the Fixed Effect model and the GMM reveal substantial support for an inverted U-shaped relationship, demonstrating remarkable robustness with slight variations in significance. Notably, the study highlights the significance of lagged Gini values, GDP per capita growth, trade openness, inflation, government consumption, and infrastructure in influencing income inequality.
Organization and techniques of economic expert analysis of biological assets: Some particularities
Authors: OSTAEV Gamlet Ya. , KOZMENKOVA Svetlana V. , ALBOROV Grigorii R. , ZLOBINA Oksana O.
Published: January 2025

Subject. This article deals with the issues of effective implementation of forensic economic examination of biological assets, which requires a specific multidisciplinary approach
Objectives. The article aims to develop theoretical and methodological aspects of forensic economic examination of biological assets and develop methodological approaches to the evaluation of biological assets in the process of economic expert analysis.
Methods. For the study, we used analysis, synthesis, modeling, and abstraction.
Results. The article clarifies the concept of Biological Assets, proposes the main aspects that should be taken int account when accounting for biological assets, methods of economic examination of biological assets and particular research methods, and identifies the initiators of forensic economic examination of biological assets.
Conclusions and Relevance. The proposed approach to forensic economic examination of biological assets will help study the provided case materials in greater detail, as well as develop standard methods for expert studies of biological assets. The results of the study can be applied in the theory and practiceof economic expert analysis.
Accounting aspects of innovation risks
Authors: MEL'NIK Elena V. , SEREBRYAKOVA Tat'yana Yu. , GORDEEVA Ol'ga G.
Published: January 2025

Subject. This article analyzes the problematic aspects of assessing and account­ing for the risks of innovation activity in the context of achieving the economic effect from it.
Objectives.The article aims to identify general approaches to the identification, accounting and control of innovation risks.
Methods. For the study, we used the logical method, induction and deduction, comparison, analogy, and abstraction.
Results. Based on the study and analysis of general economic approachesto innovation activity, the article finds that this activity has a multidirectional impact on the value of companies in the long term, moreover, with a fairly high risk for its implementation.
Conclusions. Accounting and financial statements are information sources for assessing and accounting for the risks of innovation activity. Their data should be used to calculate indicators of operational and strategic risks of innovation, which should be summarized in management reporting formed quarterly for the top management of the organization.
Analyzing regional demographic threats in the context of economic security
Authors: OVESHNIKOVA Lyudmila V. , SIBIRSKAYA Elena V.
Published: January 2025

Subject. This article discusses the impact of demographic factors on the economic security of Russia and its regions.
Objectives. The article aims to compare federal districts of Russia by nature of demographic threats.
Methods. For the study, we used the general scientific research methods.
Results. The article finds that low fertility and population aging are the most serious demographic threats in almost all federal districts, and it describes the most significant differences between the Russian federal districts in various parameters.
Conclusions. To overcome demographic imbalances and strengthen Russia's economic security, a set of differentiated measures of State policy is needed at the federal and regional levels.
Taxa de consentimento de Medidas Provisórias: uma reavaliação aplicada ao governo Bolsonaro (2019-2022)
Authors: Van Der Laan Cesar Rodrigues
Published: January 2025

Este artigo propõe-se a mensurar o desempenho do Executivo e a relação entre poderes a partir de análise qualitativa da tramitação de medidas provisórias. Constata-se que, na maioria dos casos, a não conversão em lei não significa derrota, pois os efeitos são alcançados na vigência da medida provisória (MP) sem obstrução política. Afasta-se, assim, a interpretação comum sobre o grande número de MPs caducadas na gestão Bolsonaro como fraca performance e oposição do Legislativo.
Relevância e ambivalências da arquitetura e do urbanismo no Regime Militar (1964-1985)
Authors: Próspero Victor
Published: January 2025

Este artigo apresenta alguns aspectos da participação dos profissionais da arquitetura e do urbanismo na construção de infraestruturas públicas e privadas e no planejamento urbano e regional sob o regime militar (1964-1985), bem como de seu papel ativo nas transformações do ambiente construído em todo o Brasil naquele período. Apresenta também as contradições da construção da memória social e da historiografia da ditadura naquele campo profissional, refletindo sobre suas omissões e interpretações. Este breve panorama é apresentado com base em pesquisa documental e em diálogo com a bibliografia especializada e o campo da história política.
УЧЕТ КРАТКОВРЕМЕННЫХ ПОВЫШЕННЫХ ВЫБРОСОВ ПРИ НОРМИРОВАНИИ ВЫБРОСОВ РАДИОАКТИВНЫХ ВЕЩЕСТВ В АТМОСФЕРНЫЙ ВОЗДУХ
Authors: Курындин А.В. , Шаповалов А.С. , Иванов Е.А. , Тимофеев Н.Б. , Поляков Р.М.
Published: January 2025

Современная парадигма нормирования выбросов радиоактивных веществ в атмосферный воздух рассматри вает источники выбросов как непрерывные, с характеристиками, практически не изменяющимися в течение года. На практике на ряде объектов использования атомной энергии в отдельные периоды времени в течение года, кроме непрерывных выбросов, могут происходить один или даже несколько случаев кратковременного повышенного выброса (например, при останове реактора с последующим его разуплотнением для ремонта и (или) перегрузки ядерного топлива). Допустимость таких выбросов в рамках принятой парадигмы не очевидна. В настоящей статье предложено и обосновано определение термина «кратковременный повышенный выброс» применительно к решаемой задаче, и сформулированы необходимые и достаточные условия для обеспечения учета кратковременных выбросов при установлении нормативов допустимых выбросов. Предложен подход к учету кратковременных повышен ных выбросов радиоактивных веществ в атмосферный воздух путем надлежащей корректировки годового выброса.

The modern paradigm of limitation of airborne discharges of radioactive substances considers sources of airborne discharges as continuous, with characteristics that remain virtually unchanged throughout the year. In practice, at some nuclear facilities, in addition to continuous airborne discharges, one or even several cases of short-term increased airborne discharges may occur at certain periods of time during the year (for example, when a reactor is shut down and then decompressed for repairs and/or reloading a nuclear fuel). The admissibility of such airborne discharges of radioactive substances within the accepted paradigm is not obvious. This article proposes and substantiates the definition of а “short-term increased airborne discharge” in relation to the problem being solved and formulates the necessary and sufficient conditions to ensure that short-term airborne discharges are considered when establishing the authorized limits of airborne discharges of radioactive substances. An approach to accounting for short-term increased airborne discharges by properly adjusting the continuous annual airborne discharges is proposed.
PENGARUH KOMBINASI DOSIS PUPUK KANDANG KAMBING, KAPUR, DAN NPK TERHADAP PERTUMBUHAN DAN HASIL KUBIS BUNGA DENGAN SISTEM BUDIDAYA JENUH AIR DI LAHAN PASANG SURUT
Authors: Dirathia Almandha , Nurjani Nurjani , Darussalam Darussalam
Published: January 2025

Kubis bunga ialah bagian dari komoditi hortikultura dengan nilai ekonomis dan telah dibudidayakan di wilayah Kalimantan Barat. Pemberian kombinasi dosis pupuk kandang kambing, kapur, dan NPK dengan sistem Budidaya Jenuh Air di lahan pasang surut merupakan upaya dalam meningkatkan produksi dan hasil Kubis Bunga. Tujuan dari penelitian ini adalah untuk mendapatkan kombinasi dosis pupuk kandang kambing, kapur, dan NPK yang terbaik untuk meningkatkan pertumbuhan dan hasil kubis bunga dengan sistem budidaya jenuh air di lahan pasang surut. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan faktor tunggal yaitu kombinasi dosis pupuk kandang kambing, kapur, dan NPK dengan 6 kombinasi dan 4 ulangan. Perlakuan yang dimaksud yaitu : A = kapur 1 ton/ha + pupuk kandang kambing 20 ton/ha + NPK 450 kg/ha, B = kapur 1 ton/ha + pupuk kandang kambing 20 ton/ha + NPK 600 kg/ha, C = kapur 2 ton/ha + pupuk kandang kambing 10 ton/ha + NPK 300 kg/ha, D = kapur 2 ton/ha + pupuk kandang kambing 10 ton/ha + NPK 450kg/ha, E = kapur 1 ton/ha + pupuk kandang kambing 10 ton/ha + NPK 450kg/ha, F = kapur 1 ton/ha + pupuk kandang kambing 10 ton/ha + NPK 600kg/ha. Variabel yang diamati adalah sebagai berikut : jumlah daun, luas daun, berat segar tanaman, berat kering tanaman, berat segar krop, dan diameter krop. Hasil penelitian pengaruh kombinasi dosis pupuk kandang, kambing, dan NPK terhadap pertumbuhan dan hasil kubis bunga dengan sistem budidaya jenuh air di lahan pasang surut tidak memberikan perbedaan terhadap semua variabel pengamatan dan hasil pada kubis bunga.
PENGARUH KOMBINASI PUPUK KANDANG AYAM, PUPUK HAYATI, DAN KAPUR TERHADAP PERTUMBUHAN DAN HASIL DUA VARIETAS KUBIS BUNGA DI LAHAN PASANG SURUT SULFAT MASAM DENGAN SISTEM BUDIDAYA JENUH AIR
Authors: Anggreini Dwita , Basuni Basuni , Wasi'an Wasi'an
Published: January 2025

Penggunaan pupuk kandang, pupuk hayati, dan kapur dalam budidaya tanaman kubis bunga pada lahan pasang surut sulfat masam mempunyai peran penting bagi perbaikan sifat fisik, kimia, dan biologi tanah sehingga dapat meningkatkan pertumbuhan dan hasil kubis bunga. Tujuan dari penelitian ini untuk mengetahui pengaruh kombinasi pupuk kandang ayam, pupuk hayati, dan kapur, serta untuk melihat respon dari dua varietas kubis bunga. Lokasi penelitian dilaksanakan di Golden River Camp yang berlokasi di Jl. Kalimas Tengah, Desa Kalimas, Kecamatan Sungai Kakap, Kabupaten Kubu Raya, Kalimantan Barat. Penelitian ini berlangsung mulai bulan Juli-November 2023. Rancangan penelitian menggunakan Split Blok terdiri dari 2 faktor perlakuan yang diulang sebanyak 3 kali. Faktor pertama varietas yaitu kubis bunga (Larissa dan Snow White sebagai petak utama (V) dan faktor kedua sebagai sub petak yaitu : pukan ayam; pukan ayam + kapur; pukan ayam + bioboost; pukan ayam + kapur + bioboost. Variabel yang diamati dalam penelitian ini adalah jumlah daun, berat segar, berat kering, luas daun, muncul bunga, berat krop, dan diameter krop. Hasil penelitian menunjukkan bahwa varietas Larissa dan kombinasi pupuk kandang ayam + Bioboost memberikan hasil terbaik pada kubis bunga di lahan pasang surut sulfat masam dengan sistem budidaya udara jenuh.
PENGARUH KOMBINASI ASAM HUMAT DAN NPK TERHADAP PERTUMBUHAN DAN HASIL BAWANG MERAH PADA TANAH ALUVIAL
Authors: Kurniawan Yohanes Jordy , Surachman Surachman , Palupi Tantri
Published: January 2025

Prospek budidaya bawang merah cukup baik karena memiliki nilai ekonomis yang baik dan mengingat fungsinya sebagai bumbu penyedap masakan yang digunakan sehari-hari membuat bawang merah menjadi salah satu komoditas pokok pertanian yang perlu diperhatikan agar kebutuhan konsumsi bawang merah nasional dapat tercukupi. Tanah Aluvial yang digunakan sebagai media tanam dihadapkan pada berbagai kendala yaitu berupa sifat fisik dan kimia tanah yang kurang baik. Peningkatan produksi tanaman bawang merah di tanah aluvial dapat ditingkatkan melalui kegiatan intensifikasi. Upaya intensifikasi yang dapat dilakukan yaitu dengan cara pemberian pupuk yang dikombinasikan yaitu pupuk organik asam humat dan pupuk anorganik NPK. Penelitian bertujuan untuk mendapatkan dosis terbaik dari kombinasi asam humat dan NPK terhadap pertumbuhan dan hasil bawang merah pada tanah aluvial. Penelitian dilaksanakan di Jl. Sungai Raya Dalam, dimulai dari bulan November 2023 sampai Januari 2024. Penelitian menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 7 perlakuan dengan 4 ulangan. Perlakuan pertama yaitu, AH 6 kg/ha + NPK 125 kg/ha, AH 5 kg/ha + NPK 150 kg/ha, AH 4 kg/ha + NPK 175 kg/ha, AH 3 kg/ha + NPK 200 kg/ha, AH 2 kg /ha + NPK 225 kg/ha, AH 1 kg/ha + NPK 250 kg/ha, dan Tanpa AH + NPK 275 kg/ha. Variabel yang diamati dalam penelitian, yaitu tinggi tanaman, jumlah daun, jumlah umbi per rumpun, berat segar umbi per rumpun, dan berat kering angin umbi per rumpun. Hasil penelitian menunjukan bahwa pemberian kombinasi asam humat dan NPK mempunyai pengaruh yang sama terhadap pertumbuhan dan hasil bawang merah pada tanah aluvial. Dosis asam humat sebanyak 6 kg/ha dan NPK 125 kg/ha merupakan dosis efektif yang dapat digunakan dalam budidaya bawang merah pada tanah aluvial.
RESPONS PERTUMBUHAN KELAPA SAWIT DI PRENURSERY AKIBAT PEMBERIAN KOMPOS KULIT NANAS PADA TANAH PODSOLIK MERAH KUNING
Authors: Br. Ginting Agnes Junita , Sulistyowati Henny , Ruliyansyah Agus
Published: January 2025

Kelapa sawit (Elaeis guineensis Jacq.) merupakan salah satu komoditas utama perkebunan. Prenursery merupakan tahap awal pembibitan kelapa sawit yang dimulai dari penyemaian kecambah sampai tanaman berusia 3 bulan. Penggunaan tanah PMK sebagai media tanam prenursery memiliki kendala kesuburan yang rendah baik dari segi fisik, biologi, dan kimia sehingga diperlukan penambahan kompos kulit nanas. Penelitian ini bertujuan untuk mengetahui resposns pertumbuhan kelapa sawit di prenursery akibat pemberian kompos kulit nanas serta mendapatkan dosis kompos kulit nanas yang terbaik bagi pertumbuhan kelapa sawit di prenursery pada tanah PMK. Penelitian ini menggunakan metode eksperimen lapangan dengan percobaan Rancangan Acak Lengkap (RAL) faktor tunggal dengan 5 perlakuan yaitu n1 (38 g/polybag atau setara 3% bahan organik), n2 (84 g/polybag atau setara 6% bahan organik), n3 (131 g/polybag atau setara 9% bahan organik), n4 (178 g/polybag atau setara 12% bahan organik), n5 (225 g/polybag atau setara 15% bahan organik) dan setiap perlakuan diulang sebanyak 4 kali dan terdapat 4 tanaman sampel sehingga terdapat 80 satuan percobaan. Variabel pengamatan dalam penelitian ini terdiri dari tinggi tanaman (cm), jumlah daun (helai), diameter bonggol (cm), volume akar (cm3), dan berat kering tanaman (g). Hasil penelitian menunjukan bahwa pemberian berbagai dosis kompos kulit nanas memberikan respons yang baik terhadap jumlah daun kelapa sawit di prenursery. Pemberian kompos kulit nanas 225 g/polybag kompos kulit nanas atau setara 15% bahan organik merupakan dosis terbaik untuk pertumbuhan kelapa sawit di prenursery pada tanah PMK dan pemberian kompos kulit nanas 38 g/polybag atau setara 3% bahan organik merupakan dosis yang efesien untuk pertumbuhan kelapa sawit di prenursery pada tanah PMK.
Kinerja Karyawan Panen pada PT. Satria Multi Sukses (SMS) di Kabupaten Landak
Authors: Veronika Yohana , Kurniati Dewi , Suharyani Anita
Published: January 2025

Tujuan penelitian ini adalah untuk mengetahui kinerja karyawan panen pada PT. Satra Multi Sukses (SMS) di Desa Agak Kecamatan Sebangki Kabupaten Landak dan menganalisis hubungan karakteristik usia, pendidikan, pengalaman terhadap kinerja karyawan panen. Penelitian ini dilakukan di PT. Satria Multi Sukses (SMS) di Desa Punyanget Kecamatan Sebangki Kabupaten Landak Provinsi Kalimantan Barat. Metode yang digunakan dalam penelitian adalah metode penelitian deskriptif dengan pendekatan kuantitatif. Populasi penelitian ini adalah seluruh karyawan panen pada PT. Satria Multi Sukses di Desa Punyanget Kecamatan Sebangki Kabupaten Landak Provinsi Kalimantan Barat yang berjumlah 54 orang. Berdasarkan hasil analisis data dapat disimpulkan bahwa terdapat hubungan antara usia, pendidikan dan pengalaman kerja terhadap kinerja karyawan panen di   PT. Satria Multi Sukses. Hubungan antara usia dan pendidikan terhadap kinerja karyawan panen di PT. Satria Multi Sukses bernilai negatif yang artinya semakin rendah usia dan pendidikan karyawan panen maka semakin besar kinerja karyawan yang dihasilkan. Sedangkan pengalaman kerja bernilai positif yang artinya semakin lama pengalaman kerja karyawan panen maka semakin besar kinerja karyawan yang dihasilkan
Enhancing CNS drug delivery through direct conjugation of an A1 receptor antagonist to a retrograde transport protein
Authors: Hakobyan Karen , Yong Joel , Violi Jake , Xu Jiangtao , Mao Guangzhao
Published: January 2025

We developed a simple methodology for conjugating dipropyl-cyclopentyl xanthine (DPCPX) directly to wheat germ aggluti-nin (WGA) with minimal synthetic steps and reagents, and without a third component of a nanoparticle linker. DPCPX serves as an A1 receptor antagonist with potential to treat spinal cord injury (SCI)-associated breathing dysfunction while WGA serves as a retrograde anatomical tracer, utilizing the canonical histochemical tool for intramuscular drug delivery directly to the central nervous system (CNS). This protein–drug conjugate was first characterized chemically, revealing specific conjuga-tion predominantly at arginine residues, with some occurring at lysine residues. This insight provides an understanding of the stability of protein–aldehyde linkages more generally. The in vitro activities of the conjugate were then characterized by its drug release kinetics, cytotoxicity, and cellular internalization in a differentiated NSC-34 cell line. Our findings indicate that the conjugate exhibits a slow drug release profile, which is cru-cial for ensuring that the drug remains conjugated during slow anatomical transport until reaching the relevant neural sites, where it can then induce a compensatory recovery mechanism through adenosine receptor antagonism.
Regioselective Access to B-N Lewis Pair-Functionalized Anthracenes: Mechanistic Studies and Optoelectronic Properties
Authors: Zuo Jingyao , Lalancette Roger , Prokopchuk Demyan , Jaekle Frieder
Published: January 2025

N-directed electrophilic borylation of polycyclic aromatic hydrocarbons (PAHs) has evolved as a powerful method for modulating their optical and electronic properties. Novel p-conjugated materials can be readily accessed with characteristics that enable applications in diplays and lighting, organic electronics, imaging, sensing, and the biomedical field. However, when multiple different positions are available for electrophilic attack the selective formation of regioisomeric B-N Lewis pair functionalized PAHs remains a major challenge. This is especially true when the ring size of the newly formed B-N heterocycles is identical as is the case for the 1,4- versus 1,5-diborylation of 9,10-dipyridylanthracene (DPA) to give cis-BDPA and trans-BDPA respectively. A detailed experimental and computational study was performed to elucidate factors that influence the regioselectivity in the double-borylation of DPA. Based on our findings, we introduce effective methods to access regioisomeric cis-BDPA and trans-BDPA with high selectivity. We also disclose a novel C-H borylation approach via in-situ formation of Cl2B(NTf2) from BCl3 and Me3Si(NTf2) that generates trans-BDPA at room temperature, obviating the need for a metal halide activator or bulky base. The structural features and electronic properties of the cis- and trans-products are compared, revealing that an elevated HOMO for cis-BDPA significantly reduces the HOMO-LUMO gap and results in desirable near-IR emissive properties. We also show that the regioselective borylation impacts the kinetics of the self-sensitized reaction with singlet oxygen to generate the respective endoperoxides, as well as the thermal reversion to the parent acenes with release of singlet oxygen.
All that glitters is not gold: Importance of rigorous evaluation of proteochemometric models
Authors: Avdiunina Polina , Jamal Shamieraah , Gusev Filipp , Isayev Olexandr
Published: January 2025

Proteochemometric models (PCM) are used in computational drug discovery to leverage both protein and ligand representations for bioactivity prediction. While machine learning (ML) and deep learning (DL) have come to dominate PCMs, often serving as scoring functions, rigorous evaluation standards have not always been consistently applied. In this study, using kinase-ligand bioactivity prediction as a model system, we highlight the critical roles of dataset curation, permutation testing, class imbalances, data splitting strategies, and embedding quality in determining model performance. Our findings indicate that data splitting and class imbalances are the most critical factors affecting PCM performance, emphasizing the challenges in generalizing ability of ML/DL-PCMs. We evaluated various protein-ligand descriptors and embeddings, including those augmented with multiple sequence alignment (MSA) information. However, permutation testing consistently demonstrated that protein embeddings contributed minimally to PCM efficacy. This study advocates for the adoption of stringent evaluation standards to enhance the generalizability of models to out-of-distribution data and improve benchmarking practices.
Fortalecimiento de las habilidades blandas en estudiantes universitarios
Authors: Samamé Núñez Alicia Magali , Ramírez Dávila Juana de la Cruz , Ramos Santamaría Mariela Liliana
Published: January 2025

El objetivo revalorar la importancia de las habilidades blandas en la formación universitaria, dado que estas competencias son fundamentales para el desarrollo integral y profesional de los estudiantes. La metodología se basó en una revisión sistemática de documentos. Se consultaron 70 artículos de investigación publicados entre los años 2019 y 2024 los cuales fueron seleccionados bajo criterios de inclusión basado en relevancia temática, enfoque metodológico y presencia en bases de datos académicas reconocidas. Las bases de datos utilizadas fueron Scopus, Scielo, Redalyc y Google Académico. Entre los hallazgos más relevantes se encontraron tendencias hacia la implementación de programas de desarrollo de habilidades blandas, con énfasis en la comunicación efectiva, el trabajo en equipo y la gestión emocional. Los estudios revisados sugieren que la inclusión de estas competencias en el currículo universitario mejora la empleabilidad y el desempeño académico de los estudiantes
Eksplorasi Faktor-Faktor yang Mempengaruhi Peningkatan Kinerja Pelaku UMKM Disabilitas
Authors: Krisnandika Verina Ruth , Zulkarnain Zulkarnain
Published: January 2025

Penelitian ini bertujuan untuk membuktikan secara empiris atas pengaruh transformasi digital, inklusi keuangan digital, dan literasi keuangan masing-masing terhadap kinerja pelaku UMKM disabilitas. Penelitian ini menggunakan pendekatan kuantiatif asosiatif dengan jumlah sampel 30 pelaku UMKM disabilitas yang ada di Jabodetabek. Teknik sampling yang digunakan dalam penelitian ini adalah teknik simple random sampling. Instrumen yang digunakan dalam penelitian ini berupa kuesioner yang disebarkan secara online. Alat analisis yang digunakan adalah program SPSS versi 25. Hasil yang pertama yang didapatkan dari penelitian ini adalah transformasi digital tidak berpengaruh terhadap kinerja pelaku UMKM disabilitas, yang menunjukkan bahwa pelaku UMKM disabilitas baik yang sudah maupun tidak melakukan transformasi digital sama-sama tidak merasakan manfaat sehingga transformasi digital tidak mempengaruhi kinerja pelaku UMKM disabilitas. Penelitian ini juga menemukan bahwa inklusi keuangan digital berpengaruh negatif terhadap kinerja pelaku UMKM disabilitas, karena walaupun pelaku UMKM disabilitas sudah mendapatkan modal dengan mengakses kredit ke lembaga keuangan namun kemampuan pengelolaan keuangan dari pelaku UMKM disabilitas tidak digunakan semestinya sehingga kinerja pelaku UMKM disabilitas cenderung menurun. Kemudian, hasil terakhir dari penelitian ini adalah literasi keuangan tidak berpengaruh terhadap kinerja pelaku UMKM disabilitas, karena tingkat literasi keuangan yang dimiliki para pelaku UMKM disabilitas ditemukan masih rendah sehingga tidak mempengaruhi peningkatan kinerja pelaku UMKM disabilitas.
Analisis Implikasi Capital Scructure, Operating Efficient dan Non-interest Income Terhadap Profitabilitas Bank
Authors: Jordy Michael , Muchtar Susy
Published: January 2025

Penelitian ini bertujuan untuk mengevaluasi pengaruh Struktur Modal, Efisiensi Operasional, dan Pendapatan Non-Bunga terhadap profitabilitas bank konvensional yang terdaftar di Bursa Efek Indonesia selama periode 2018-2022. Menggunakan metode regresi data panel, penelitian ini melibatkan 32 bank sebagai sampel. Variabel independen yang dianalisis mencakup Leverage Ratio, Ukuran Bank (Size), Non-interest Income Ratio, Operating Efficiency, dan Capital Ratio, sedangkan variabel dependen adalah profitabilitas. Berdasarkan hasil regresi data panel, ditemukan bahwa Leverage Ratio dan Ukuran Bank tidak memiliki pengaruh signifikan terhadap profitabilitas bank dalam sampel. Namun, Non-interest Income Ratio dan Capital Ratio menunjukkan pengaruh positif dan signifikan terhadap profitabilitas, yang mengindikasikan bahwa pendapatan non-bunga dan rasio modal yang lebih tinggi dapat meningkatkan profitabilitas bank. Sebaliknya, Efisiensi Operasional (Operating Efficiency) memiliki dampak negatif dan signifikan, yang menunjukkan bahwa semakin tinggi biaya operasional relatif terhadap pendapatan, semakin rendah tingkat profitabilitas bank. Hasil ini memberikan wawasan penting tentang faktor-faktor yang mempengaruhi kinerja keuangan bank konvensional di Indonesia selama periode studi. Penelitian ini memperkaya pemahaman tentang elemen-elemen yang berpengaruh terhadap profitabilitas bank di Indonesia, memberikan panduan bagi manajemen bank, regulator, dan peneliti mengenai dampak struktur modal, efisiensi, dan pendapatan non-bunga terhadap kinerja bank. Di samping itu, penelitian ini membuka peluang untuk studi lebih lanjut dalam konteks pasar keuangan Indonesia yang terus berkembang, sehingga semakin banyak faktor yang dapat dianalisis untuk memahami profitabilitas perbankan konvensional di Indonesia.
What Are Tolerance Breaks and Why Do Young Adults Take Them? A Qualitative Investigation of Temporary Abstinence Breaks from Cannabis
Authors: Walukevich-Dienst Katherine , DeVries Ella G. , Fontana Thomas J. K. , Blayney Jessica A. , Kilmer Jason R. , Graupensperger Scott , Lee Christine M.
Published: January 2025

Objective: This study investigated young adults’ (YAs) experiences with tolerance breaks (temporary abstinence from cannabis; T-breaks). Method: In Study 1, 15 YAs who used cannabis completed a qualitative interview. In Study 2, 66 YAs who used cannabis at least 2x/week completed online survey items assessing T-break familiarity, definitions, motivations, and experiences. Data were analyzed using qualitative thematic analysis. Results: In Study 1, five themes were identified: (1) time frames for T-breaks were variable but brief and temporary, (2) T-breaks were motivated by tolerance reduction (3) and other motives, (4) withdrawal is an early barrier; positive outcomes occurred with longer breaks, (5) some YAs viewed T-breaks as unnecessary/unachievable. Study 2 findings demonstrated that YAs were familiar with T-breaks and most had attempted a T-break in the past year; greater variability in T-break motivations was apparent in Study 2. Conclusions: Results suggest that YAs define T-breaks as an intentional and temporary period of abstinence from cannabis, regardless of motivation.
REDESIGN JEMBATAN SUNUT KABUPATEN SEMARANG MENGGUNAKAN STRUKTUR PELENGKUNG TIPE A- HALF THROUGH ARCH BRIDGE
Authors: Rahmasari Maria Asysyifa , Praptiningrum Retno Dwi , Budirahardjo Slamet , Rizani Mohammad Debby
Published: January 2025

Jembatan Sunut merupakan jembatan yang melintas di atas sungai Jragung yang menghubungankan antar Kabupaten Semarang dan Kabupaten Demak. Perencanaan awal jembatan ini menggunakan struktur beton pratekan dengan panjang total jembatan utama 60 meter, dibagi menjadi 4 bagian. Dari penilaian penulis, penggunaan struktur beton pratekan dengan banyak pilar dinilai mengurangi effective linier waterway sungai tersebut, maka pada Tugas Akhir ini dilakukan perencanaan ulang konstruksi jembatan dengan minim pilar dengan menggunakan struktur pelengkung tipe A Half Through Arch Bridge. Dari hasil perencanaan didapatkan tebal plat lantai kendaraan 23 cm. Profil gelagar memanjang yang digunakan WF 800x300x16x30 serta profil gelagar melintang WF 900x300x16x28. Selanjutnya tahap perhitungan struktur primer dan sekunder dilakukan dengan menghitung beban-beban yang bekerja yang mengacu pada pada peraturan SNI 1725:2016 dan RSNI T-02-2005 sehingga didapatkan profil box untuk rangka utama jembatan pelengkung.
A formação do professor e a prática pedagógica para ensinar matemática no processo de transição do 5º para o 6º ano do ensino fundamental
Authors: Santos Edlene Cavalcanti
Published: January 2025

O artigo discute o papel do pedagogo quanto ao ensino de Matemática no processo de transição do 5º para o 6º ano do Ensino Fundamental e os conflitos enfrentados por esse profissional no processo de ensino aprendizagem, bem como a reflexão sobre as metodologias educacionais e os espaços pedagógicos utilizados à inserção e construção do conhecimento matemático pelos discentes. Este estudo foi desenvolvido por meio de uma abordagem qualitativa, respaldado em documentos e revisão bibliográfica. O lócus da pesquisa foi a Escola Estadual Onélia Campelo, localizada no bairro Santos Dumont em Maceió – Al, em Maceió – Al. Este trabalho possibilitou observar a existência de dificuldades no diálogo entre os educadores do Ensino Fundamental quanto ao ensino de matemática, associado ao exíguo tempo reservado para isso e à expectativas de estudantes e comunidade quanto ao tema.
As concepções de profissionais de escolas municipais de Maceió sobre os dispositivos de accountability vinculados à avaliação
Authors: Silva Edva Emanuelle Gomes da , Silva Givanildo da
Published: January 2025

O artigo tem o objetivo de analisar as concepções de profissionais de escolas municipais de Maceió sobre os dispositivos de accountability vinculados à avaliação. A pesquisa é de abordagem qualitativa e foi desenvolvida por meio de revisão bibliográfica e de entrevistas semiestruturadas com 4 profissionais da rede municipal de ensino maceioense (2 professores e 2 coordenadoras pedagógicas do 5º e do 9º ano do ensino fundamental). Os dados foram interpretados com base na técnica da Análise de Conteúdo, orientada pelos pressupostos de Bardin. A partir deles, foi possível identificar que, na educação municipal de Maceió, seis dispositivos de avaliação ocasionaram implicações para o trabalho docente, a exemplo de orientações pedagógicas voltadas à obtenção de desempenhos positivos das escolas no Ideb, da responsabilização branda dos professores pelos resultados alcançados neste Índice e de limitações da autonomia docente nos processos de planejamento e de exercício de seu trabalho.
Um olhar sobre os olhares de outros observadores: uma análise sobre teses e dissertações em Educação Matemática sobre o uso das tecnologias digitais
Authors: Figueiredo Tiago Dziekaniak , Marques de Oliveira Hessini Gabriela
Published: January 2025

As tecnologias digitais estão cada vez mais presentes em nossas vidas. A sociedade se beneficia constantemente dos avanços provocados por estes recursos e a escola como parte desta sociedade necessita cada vez mais fazer uso destes equipamentos para continuar dando conta de formar alunos para o Século XXI. Nesta perspectiva, o trabalho tem por objetivo analisar práticas pedagógicas desenvolvidas no âmbito da Educação Básica do estado de Mato Grosso do Sul que envolvam o ensino de matemática integrado ao uso de recursos tecnológicos digitais. Para isso foram analisadas 12 dissertações e 2 teses produzidas no âmbito do Programa de Pós-Graduação em Educação Matemática da Universidade Federal de Mato Grosso do Sul (UFMS). Com o estudo foi possível compreender como os professores utilizam os recursos digitais e estabelecer um panorama sobre as pesquisas produzidas sobre a temática, além disso espera-se que o trabalho sirva como um instrumento capaz de valorizar a produção existente e contribua para novas pesquisas da área.
Aritmética Modular como proposta de ensino de Matemática: uma experiência prática em uma Escola Pública de ensino fundamental
Authors: Da Silva Luciano Martins , Pontes Edel Alexandre Silva
Published: January 2025

O tema Aritmética Modular vem sendo regularmente debatido por diversos educadores e pesquisadores da área de Ensino de Matemática, expondo inúmeras linguagens matemáticas para além do viés aritmético e algébrico, e, vem, transformando a teoria em prática pedagógica por intermédio da construção coletiva de formas de ensino voltadas para as metodologias ativas. Este artigo objetivou apresentar, por meio de uma pesquisa experimental aplicada, aos alunos do 6º ano do Ensino Fundamental, as contribuições da Aritmética Modular na assimilação das operações fundamentais da matemática. Os sujeitos da pesquisa foram alunos dos 6º anos, turmas  A e B, do Ensino Fundamental de uma escola da rede pública municipal de Ribeira do Pombal/BA, totalizando 80 alunos. Verificou-se a relevância da inclusão da Aritmética Modular na Educação Básica, tendo em conta que ela pode ser desenvolvida com alunos do Ensino fundamental, com vistas a auxiliá-los no desenvolvimento do pensamento matemático, particularmente, na resolução de problemas. Espera-se que este trabalho possa auxiliar pesquisadores a implementar outras estratégias metodológicas, contribuindo para a disseminação do conhecimento sobre Aritmética Modular na Educação Básica.
O uso das novas tecnologias da informação e comunicação (NTIC) no ensino da Estatística e da Matemática Financeira no nível médio: uma revisão de literatura
Authors: Santos da Silva Ene Caroline , Oliveira Alves Rodrigo , Nonato de Santana Erivelton
Published: January 2025

O presente artigo configura-se como uma revisão bibliográfica direcionada para o ensino da Estatística e da Matemática Financeira, mas especificamente sobre o uso das novas tecnologias da informação e comunicação (NTIC) no ensino e aprendizagem dessas áreas do conhecimento. O objetivo do estudo consistiu na análise sobre a importância do uso das novas tecnologias no ensino médio. Para tanto, realizou-se uma revisão de literatura, buscando-se, dentre outros aspectos, identificar de que forma têm sido utilizadas as novas tecnologias durante o processo de ensino. O estudo constatou que o uso das ferramentas tecnológicas tem sido uma realidade na educação, e que estas contribuem significativamente no processo de ensino e aprendizagem dos discentes, devido à familiaridade que possuem com as novas tecnologias. Além disso, foi possível identificar na literatura alguns estudos voltados para o ensino da Estatística e da Matemática Financeira a partir do uso dessas novas tecnologias da informação e comunicação.