bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of snow-related parameters in the Noah land surface model (v3.4.1) using a micro-genetic algorithm (v1.7a)
Authors: Lim Sujeong , Gim Hyeon-Ju , Lee Ebony , Lee Seungyeon , Lee Won Young , Lee Yong Hee , Cassardo Claudio , Park Seon Ki
Published: November 2022

Abstract. Snowfall prediction is important in winter and early spring because snowy conditions generate enormous economic damages. However, there is a lack of previous studies dealing with snow prediction, especially using land surface models (LSMs). Numerical weather prediction models directly interpret the snowfall events, whereas LSMs evaluate the snow cover, snow albedo, and snow depth through interaction with atmospheric conditions. Most LSMs include parameters based on empirical relations, resulting in uncertainties in model solutions. When the initially developed empirical parameters are local or inadequate, we need to optimize the parameter sets for a certain region. In this study, we seek the optimal parameter values in the snow-related processes – snow cover, snow albedo, and snow depth – of the Noah LSM, for South Korea, using the micro-genetic algorithm and the in situ surface observations and remotely sensed satellite data. Snow data from observation stations representing five land cover types – deciduous broadleaf forest, mixed forest, woody savanna, cropland, and urban and built-up lands – are used to optimize five snow-related parameters that calculate the fractional snow cover, maximum snow albedo of fresh snow, and fresh snow density associated with the snow depth. Another parameter, reflecting the dependence of fractional snow cover on the land cover types, is also optimized. Optimization of these six snow-related parameters has led to improvement in the root mean squared errors by 17.0 %, 6.2 %, and 3.3 % in snow depth, snow albedo, and fractional snow cover, respectively. In terms of the mean bias, the underestimation problems of snow depth and overestimation problems of snow albedo have been alleviated through optimization of parameters calculating the fresh snow by about 44.2 % and 31.0 %, respectively.
Accuracy of numerical wave model results: application to the Atlantic coasts of Europe
Authors: Alday Matias , Ardhuin Fabrice , Dodet Guillaume , Accensi Mickael
Published: November 2022

Abstract. Numerical wave models are generally less accurate in the coastal ocean than offshore. It is generally suspected that a number of factors specific to coastal environments can be blamed for these larger model errors: complex shoreline and topography, relatively short fetches, combination of remote swells and local wind seas, less accurate wind fields, presence of strong currents, bottom friction, etc. These factors generally have strong local variations, making it all the more difficult to adapt a particular model setup from one area to another. Here we investigate a wide range of modeling choices including forcing fields, spectral resolution, and parameterizations of physical processes in a regional model that covers most of the Atlantic and North Sea coasts.
The effects of these choices on the model results are analyzed with buoy spectral data and wave parameter time series. Additionally, satellite altimeter data are employed to provide a more complete performance assessment of the modeled wave heights as a function of the distance to the coast and to identify areas where wave propagation is influenced by bottom friction. We show that the accurate propagation of waves from offshore is probably the most important factor on exposed shorelines, while other specific effects can be important locally, including winds, currents, and bottom friction.
Wild Landscape Perception in the Iliad. The Early Presence of Emotions Associated with Forests and Mountains in Ancient Greek Imagery
Authors: García Martín María Luisa
Published: November 2022

How did ancient Greeks experience their relationship with wild Nature? What feelings did a walk in the forest or a night spent in the woods evoke in them? Over the centuries, literature has built bridges between them and us and can bring us a little closer to grasping a hint of their mentality. Our analysis of the passages and similes that mention the natural world in the Iliad could shed some light on how they perceived their natural environment. Mountains and forests aroused different feelings in the minds of ancient Greeks, showing how fear, sacredness, bravery and fascination could converge in their rich and complex perception of the landscape.
A SOCIOLOGICAL SURVEY ON SOCIAL MEDIA AND ITS ROLE FOR POLITICAL ACTIVITIES AMONG UNIVERSITY STUDENTS IN BALOCHISTAN: A CASE STUDY OF LASBELA UNIVERSITY
Authors: Latifa Mansoor, Hafiz Muhammad Raheed, Abdul Sattar
Published: November 2022

The purpose of this research was to analysis the relationship between social media usage and its impact on university students, specifically the function of media in political socialization, civic consciousness, political participation, media consumption, and the type of applications = most commonly used by students. The researchers used a quantitative descriptive technique. To complete this study project, we used purposive sampling. N-112 sample sizes were collected from the Lasbela University of Agriculture, Water and Marine Sciences in Uthal, Baluchistan, using a google survey form and a closed-ended questionnaire with a Likert scale. The responders came from a several faculties and educational levels, including undergraduate and master's degrees. The findings revealed that there is a strong link between social media use and political activity. The majority of respondents in this study said they utilized social media to learn about politics, acquire political attitudes and ideas, and learn about the political system. As a result, they spend two to five hours per day on social media platforms. Furthermore, this paper revealed the relationship between social media use and political system understanding at various levels, including local, provincial, national, and international levels, and confirmed that there was a strong positive relationship between social media use and political system understanding among Lasbela university students. The H1 and H2 hypotheses on the use of social media sites and the association between online political engagement, political socialization, and political dynamics revealed a strong positive relationship at significant levels .006, .001, and.000
Chromium isotope fractionation during adsorption of chromium(III) by soils and river sediments
Authors: Fang Ziyao , He Xiaoqing , Yu Xi , Qin Liping ,   CAS Key Laboratory of Crust-Mantle Materials and Environments, University of Science and Technology of China, Hefei 230026, China,   CAS Center for Excellence in Comparative Planetology, Hefei 230026, China
Published: November 2022

Chromium (Cr) isotope compositions of sedimentary rocks have been widely used to unravel fluctuations in atmospheric oxygen levels during geologic history. A fundamental framework of this application is that any Cr isotope fractionation in natural environments should be related to the redox transformation of Cr species [Cr(VI) and Cr(III)]. However, the behavior of Cr isotopes during non-redox Cr cycling is not yet well understood. Here, we present laboratory experimental results which show that redox-independent adsorption of Cr(III) by natural river sediments and soils can be accompanied by obvious Cr isotope fractionation. The observed Cr isotope fractionation factors (−0.06‰ – −0.95‰, expressed as 103lnα) are much smaller than those caused by redox processes. Combined with previous studies on redox-independent Cr isotope fractionation induced by ligand-promoted dissolution, we suggest that the systematic shift to highly fractionated Cr isotope compositions of sedimentary rocks is likely to represent atmospheric oxygenation, but muted signals observed in some geologic periods may be attributed to non-redox Cr cycling and should be interpreted with caution.
METABOLIC DISORDERS IN PATIENTS WITH ONCOLOGIC PATHOLOGY
Authors: ARINGAZINA R. , ZHOLDASSOVA N. , NURGALIYEVA Zh. , KURMANALIN B.А. , KAIBAGAROVA I.
Published: November 2022

Relevance: Metabolic disorders often take on a systemic character. It affects carbohydrate, lipid, and hormonal metabolism. Moreover,
these changes promote the development and aggravation of several pathologies. The prevalence of metabolic disorders, including obesity,
is increasing worldwide and in Kazakhstan.
The study focused on the clinical characteristics of metabolic syndrome (MS) components in patients with cancer comorbidities.
Methods: The materials included medical records of cancer patients with MS – 35 people (main group) and non-cancerous patients
with MS – 35 people (control group). MS was diagnosed with a combination of three symptoms: abdominal obesity, high blood pressure,
and increased high-density lipoprotein cholesterol (HDL-C) levels. The data were analyzed and processed using the STATIS-TICA 10
software package. The significance criterion was p<0.05.
Results: All studied patients were diagnosed with abdominal obesity. Indicators analysis showed a significant difference in HDL-C
concentration in the main and control groups: 3.8 mmol/L in cancer patients and 5.7 mmol/L in the controls. No significant difference in
blood pressure was found.
Conclusion: The age of patients with MS evidences a threatening tendency to develop metabolic disorders in young and middle ages.
A significantly lower concentration of LDL-C in cancer patients compared with the controls allows using this parameter to predict cancer
]development in patients diagnosed with MS. Thus, HDL-C concentration could be used as a metabolic marker for pre-symptomatic
diagnostics.
THE GLOBAL PREVALENCE OF HUMAN PAPILLOMAVIRUS CAUSING CERVICAL CANCER: A LITERATURE REVIEW
Authors: SATANOVA A. , KAIDAROVA D. , KUKUBASSOV E. , BOLATBEKOVA R. , KALDYBEKOV D. , BERTLEUOV O.
Published: November 2022

Relevance: Human papillomavirus (HPV) is the most common sexually transmitted virus in sexually active men and women. The direct
and proven relationship between HPV infection and cervical cancer development HPV global epidemiological studies to ensure prevention
in areas with high HPV prevalence.
The study aimed to analyze the global age-related HPV prevalence over the past decade.
Methods: Sources for the literature review were obtained from the PUBMED and MEDLINE databases for the past ten years by the
keywords “human papillomavirus,” “prevalence,” and “cervical cancer.” The review included randomized trials, systematic reviews, and
meta-analyses.
Results: HPV rates were the highest in Africa (24%), Eastern Europe (21.4%), and Latin America (16.1%). The most common HPV
types worldwide were HPV 16 (3.2%), 18 (1.4%), 52 (0.9%), 31 (0.8%), and 58 (0.7%).
HPV prevalence in the Republic of Kazakhstan is underexplored since epidemiological studies were conducted only in some regions.
HPV high-risk types16 and 18 prevail in the Republic of Kazakhstan.
Conclusion: The analysis of the global HPV epidemiology revealed its high prevalence in low- and middle-income countries. HPV’s
higher prevalence in young women justifies the need to improve and implement HPV vaccination programs.
India’s Security Challenge in Northern Frontier: A Historical Analysis (1950-1960)
Authors: Das Basudeb
Published: November 2022

Nepal’s geographical location affects India’s security sphere. Therefore, India has been trying to keep Nepal under its influence since independence by exploiting the existing geographical proximity, socio-cultural unity, economic transactions, etc. between the two countries. Although its form of influence is different from the British India and India has always respected Nepal’s sovereignty. China’s occupation of Tibet and its ‘Five Fingers of Tibet’ policy have further challenged India’s security. In this context, the impact of Nepal’s internal political instability on Indo-Nepal bilateral relations in the 1950s and China’s attempts to reduce India’s influence in Nepal by exploiting that instability and establishing its dominance is the subject of this article.
Ethos and Edos in Traditional Health Care Practices of Hill Korwa Tribe of Chhattisgarh
Authors: Kujur Rashmi , Kujur Nister , Kumar Singh Sanjay
Published: November 2022

The Hill Korwa is particularly vulnerable tribal group of the Chhattisgarh state of India. their natural habitats are found in Jashpur, Balrampur, Sarguja and Korba districts of the state. on the basis of censes 2011 report, there are total 37195 Hill Korwa tribes are residing in the state in 9046 households (Hand book of Tribal Welfare Dept. Govt. of C.G.). As the Hill Korwa tribe are the primitive tribal group so they can show various characteristics such as first, declining population, second, primitive technology, third, very low level of literacy and fourth subsistence level of economy (Ministry of Tribal Affairs, India), as mentioned in the article 342 of Indian constitution. this paper is basically focused to the cultural works of The Hill Korwa tribe special reference to their traditional treatment and healing procedures. the main objective of this paper is to identify the ethos and edos factors during the treatment process among Hill Korwa Tribe. the area of study belongs to fourteen villages from Bagicha and Kunkuri blocks of Jashpur district and it has been selected through lottery method of simple random sampling. an interview and case study is conducted among Hill Korwa community and participatory observation is also done to witness the way the healers used in carrying out their treatment processes in order to see the satisfaction of the people. the paper basically focused to Sociological theory of Social System introduced by Talcott Parson and Krober's concept about culture which is termed as Ethos and Edos.
Pentahelix Collaboration in Improving Taxpayer Compliance
Authors: Rahmi Notika , Selvi Selvi , Purwaningtyas Agitta Sofyan
Published: November 2022

The government has made various efforts to improve taxpayer compliance but the efforts that have been made have not been effective enough. Collaboration between stakeholders is needed in harmonizing and synergizing all components of taxpayers. This study was conducted with the aim of analyzing pentahelix collaboration in improving taxpayer compliance at Cimanggis Tax Office. The study used descriptive qualitative methods with data collection techniques through observation, interviews and literature study. The results of the study show that collaboration has been carried out by the government well by involving various parties who take an active role, namely the private sector, academia, the media and the community. Each party has its own role in helping improve taxpayer compliance. In its implementation there are several obstacles, but coordination continues to be carried out together to carry out the commitments that have been made.
Data breaches and cybercrime victimisation
Authors: Morgan Anthony , Voce Isabella
Published: November 2022

This paper draws on data from a large national survey conducted in 2021 to examine the prevalence of data breaches among Australian computer users and the relationship between data breaches and other forms of cybercrime victimisation. Almost one in 10 respondents (9.3%) said they were notified their information was exposed in a data breach in the 12 months prior to the survey. Nearly one-third of these respondents (28.0%) had also been a victim of identity crime in the same period. Respondents who had been notified of a data breach were 34 percent more likely than other respondents to have been a victim of identity crime in the 12 months prior to the survey. They were also more likely to have been a victim of online scams or fraud and ransomware. Measures to protect individuals whose information has been exposed in a data breach from other potentially related cybercrimes are essential and should be prioritised when data breaches occur.
Enslaved Persons and Their Multiple Identities in Ancient Societies
Authors: Vlassopoulos Kostas
Published: November 2022

This lecture explores the multiple identities of enslaved persons in ancient societies. Ancient masters and slaveholding societies often behaved as if the only identity that mattered for enslaved persons was their classification as slaves. While slave classification had profound implications, it was not the only identity that mattered. Employing key conceptual tools from the study of identities, it analyses the diversity of the identities of enslaved persons around six axes. The first axis concerns the imposed identity of slavery and its impact on the self-understanding of enslaved persons. The second examines work and function and the extent to which these led to the creation of identities. The third focuses on gender, family and kinship: male and female identities and the identities and roles of spouses, partners, parents, children, siblings and relatives. The fourth explores ethnic and religious identities. The fifth concerns time: the identities of freedpersons and of enslaved persons who had lived as free and how these identities related to their past. Finally, the sixth axis explores the entanglement between the diverse identities of enslaved persons and the groupness of slave identities.
The Functional Outcomes in Treatment of Displaced Extra Articular Distal Radius Fracture by Pop Alone or K-Wire Augmentation
Authors: Habib Yasir , Shami Ali , Hanif Muhammad , Rahman Obaid Ur , Zia Muhammad Shehryar , Ahmed Wazir , Akhtar Ali
Published: November 2022

Background & Objective: A distal radius fracture is responsible for one-sixth visit to the orthopedic emergency room. Although these fractures are common, the best treatment for these fractures is still controversial. The objective of the study was to compare the functional outcomes in terms of union in displaced extra articular distal radius fracture by POP alone or k-wire augmentation. Methods: A comparative study was conducted in the department of orthopedic surgery, Pakistan Institute of Medical Science, Islamabad from June to December 2021. A total of sixty (n=60) adult patients irrespective of gender with distal radial fracture were included in the study. Patients allocated in two groups, Group A included patients who were treated with above elbow POP casting after reducing the fracture, under sedation or blockage of hematoma and Group B included the patients in whom surgery was performed with k-wire by closed reduction and internal fixation. The main outcome measure of the study was functional outcomes in terms of excellent, good and fair. The chi square test was used between study groups for comparison of acceptable outcomes (excellent to good). A p value ≤ 0.05 was considered significant. Results: The average age of the patients of both groups was 38.6±15.8 years. Among 60 patients, 70% (n=42) were male and 30% (n=18) were females. In group A (POP) 30% (n=9) patients showed excellent, 23.3% (n=7) showed good and 46.7% (n=14) showed fair outcome as per our study outcomes. In group B (k-wire) 56.7% (n=17) patients showed excellent, 36.7% (n=11) showed good and 6.6% (n=2) showed fair outcome with p value 0.002. Conclusions: The study concluded that the functional outcomes in terms of union of displaced extra articular distal radius fractures, K-wire fixation showed better results than POP cast alone. Keywords: Bone wires; Casts, Surgical; Internal fixators; Radius fractures.
Knowledge, Attitude, and Practice (KAP) of mothers regarding Neonatal Jaundice in the hospital of KPK, Pakistan
Authors: Saddozai Sami Ullah , Gul Jaweria , Shukat Rizwan , Jabeen Norina , Mehmood Ahad , Abdullah Zeeshan , Ali Mubarik
Published: November 2022

Neonatal jaundice (NNJ) is a significant pathological condition that causes morbidity and mortality in 80% of preterm infants and 50-60% of full-term newborns worldwide. NNJ can result in a variety of serious complications, including irreversible brain damage and, in severe cases, death. It is very critical for mothers to detect neonatal jaundice in the early stages of babies, so proper treatment, such as therapy, can begin. Mother knowledge, attitude, and practices are extremely important in the lives of newborn babies all over the world. This study was carried out in District Headquarters Hospital, KPK, Pakistan, to determine mothers' knowledge, attitude, and practices regarding neonatal jaundice. A significant relationship between postnatal mothers’ knowledge and attitude toward neonatal jaundice was recorded in the current study. Almost 55% of mothers have a neutral attitude toward neonatal jaundice while 30% and 15% have a positive and negative attitude, respectively. The majority of mothers (30.75%) were between the ages of 21 and 25, while 25.75 and 24.50% were between the ages of 26-30 and 31-35, respectively. 64.250% of mothers were stay-at-home mothers, while 35.75% worked for the government. Illiterate (26.75%), primary (25.00%), middle (25.75%), higher (14.75%), and graduation (6.25%) level mothers participated, according to the data. Babies born to middle-class mothers had the highest rate of jaundice, followed by illiterate, primary, secondary, and graduate mothers. It was found that 55.50% of mothers had female babies and 44.50% of mothers had male babies. The majority of mothers (80.25%) were aware that jaundice changed skin colour, whereas 19.75% of mothers had a negative attitude toward skin colour. According to the majority of mothers, jaundice is a dangerous disease, while only 11.75% of mothers respond negatively. The participants in this study have a positive attitude toward Neonatal jaundice, their management measures and practices are ineffective and filled with misconceptions. More research on KAP in females is required. Keywords: Knowledge; Attitude; Practices; Neonate; Pakistan
Association of Gestational Diabetes with Parental Diabetic Mellitus and Impaired Glucose Tolerance: A Cross-Sectional Study
Authors: Memon Kamran Baig , Kumar Danish , Hussain Tazeem , Mushir Syeda Iqra , Phull Zafarullah , Kumar Suresh
Published: November 2022

Aim: To determine the association of gestational diabetes with parental diabetic mellitus and impaired glucose tolerance Study design: A cross-sectional study Place and Duration: This study was conducted at Jahra Hospital Kuwait from February 2021 to February 2022 Methodology: This study includes 100 women with gestational diabetes. They were aged 35 (±5) years. They were tested by fasting plasma glucose (fpg). There were 61 women who either had diabetes or fasting hyperglycemia (fpg = >5.4 millimole/l). A total of 35 women had their parents alive. Of these 35 women’s parents, 14 women’s parents agreed to test their metabolism. Their metabolism was tested by CIGMA (continuous infusion of glucose with model assessment). Results: Among those 14 families, 7 probands had diabetes and the other 7 had impaired glucose tolerance (IGT). The women were aged 36 (±4) years with a BMI of 27 (±5) kilograms/m2. The parents were aged 63 (±5) with a BMI of 30 (±5) kilograms/m2. The presence of glucose intolerance defined their affection status (an age and obese matched population with fpg or post-infusion attained plasma glucose levels greater than 3 standard deviation). Among those 14 families, 5 probands did not have any parent affected, which represents 35.7%, 3 probands had both parents affected, which represents 21.4%, and 6 probands had only 1 parent affect, which represents 42.9%. Only 3 of proband’s parents were affected by diabetes as explained by WHO criteria. Practical implication This paper outlines some of the growing evidence showing pregnant women with gestational diabetes mellitus are more likely to give birth to diabetic mothers. These preliminary findings' are provocative implications to encourage additional research. Conclusion: In conclusion, examining women with gestational diabetes, who have both parents available for this research, helps to find probands with IGT or diabetes. Those who had neither parents impacted with diabetes nor IGT were representing a significant portion which was much the same as elementary families of NIDDM. Keywords: diabetes mellitus, gestational diabetes, parents, impaired glucose tolerance
Primary Closure Versus Delayed Primary Closure in Perforated Appendix: A Comparative Study
Authors: Hussain Syed Aamer , Khan Mohammad Shoaib , Jamil Tariq , Rashid Zakariya , Nabi Habib Un- , Khan Abdul Wali
Published: November 2022

Introduction: The elimination of unpleasant and time-consuming dressing changes, as well as the potential reduction in overall hospital costs, are potential benefits of primary closure. Recent studies suggest that perforated appendicitis may usually be principally closed without an increase in the wound infection rate compared to delayed primary closure, suggesting that the disagreement surrounding the best ways of wound management has died down. Objective: Studying the efficacy of primary versus delayed primary closure for appendectomy in patients with perforations Study design: Ayyub Teaching Hospital Abbottabad and Timergara Teaching Hospital Dir Lower. Study duration from January 2021 to June 2021. Material and Methods: Perforated appendix patients undergoing appendectomy between the ages of 18 and 45 were included. When an appendectomy was performed, the appendicular stump was not invaginated as is sometimes done nowadays. Interrupted 2/0 vicryl was used to stand in for muscles. Within the PC group, the external oblique was stitched shut with a continuous vicryl 0 suture. Using only regular saline, the wound washed and disinfected. For patients having delayed primary closure, dressing changes occurred daily; in the case of infection dressing changes occurred twice daily until the wound was closed. After the third postoperative day or once the infection had subsided in cases of infected wounds, the wound was closed after rejuvenating the edges. On the seventh postoperative day patients were evaluated for wound infection and length of hospital stay using the operational definition of success. Results: The patients' mean age was 37.3± 610.49 years. The average number of days someone spent in the hospital was 7.38 (1.25). Women made up 37 (or 61.70%) of the total, while men accounted for 23 (or 38.30%). Thirteen patients, or 21.70 percent, had an infected wound. Wound infections occurred in 11 patients in Group-A (the primary closure group) but only 2 patients in Group-B (the delayed closure group) (delayed primary closure). When comparing the rate of wound infection in groups B and A, a statistically significant difference was discovered (p=0.005). Hospitalization time was shorter for those in group A (6.24± 0.47 days) compared to those in group B (8.53± 0.51 days); p 0.001. Conclusion: Patients with a perforated appendix benefit more with primary closure than from delayed primary closure. Keywords: Primary closure, delayed primary closure, and a perforated appendix
To Determine the Factors that Affect the Delay in Diagnosis of Acute Appendicitis, Affecting the Morbidity and Mortality of Patients
Authors: Hussain Syed Aamer , Khan Mohammad Shoaib , Jamil Tariq , Rashid Zakariya , Nabi Habib Un- , Khan Abdul Wali
Published: November 2022

Objective/aim: To reduce the morbidity and mortality associated with acute appendicitis, our study aims to identify the factors that contribute to diagnostic delays. Method: This study is a cross-sectional analysis of data collected at a tertiary care facility in Ayyub Teaching Hospital Abbottabad and Timergara Teaching Hospital Dir Lowerover the course of a year January 2022 to June 2022. All patients over the age of 16 who presented to the emergency room with acute appendicitis two or more days after the initial attack and who gave informed consent constituted the study population. All patients under the age of 16 who presented to the emergency room with signs and symptoms of acute appendicitis earlier than two days after the initial attack were excluded from the study. Patients' details were recorded in a standard proforma. Patients' ages, sexes, addresses, delays, doctors' diagnoses, and other relevant details were recorded. SPSS version 23 was used to analyse the data. Results: There were 155 patients in the study, with a mean age of 35±12 years; 95 (65.34%) were male and 60 (40.67%) were female. Forty-seven (32.0%) patients were incorrectly diagnosed by ER doctors and sent home as outpatients; fifty (33.33%) were treated by non-medical professionals such as chiropractic physicians, nurses, patients who self-medicated, spiritual healers, hakeems, and homoeopaths and thirty-two (21.33%) did not seek any medical attention at all during the initial attack of appendicitis. Lack of patient or family financial means was the leading cause of delay (45.34 percent of all cases). Conclusion: Early diagnosis and surgical intervention are critical for the effective care of acute appendicitis, which dramatically reduces complications, morbidity, and death of these patients. An immediate public education effort is required to encourage people to get the care they need at the right time and avoid difficulties. Keywords: Appendicitis, delayed appendicitis, appendicectomy, acute abdomen.
The Subline of Metastatic Prostate Cancer Cell line, DU145 expresses Tks4 and reveals distinctive Phenotype
Authors: Hq Aldhafeeri , Hs. Leong
Published: November 2022

Cancer metastasis is the process of dissemination of cancer cells from their original site and localization in distant sites. During this journey, metastatic cancer cells have to undergo several phenotypical/ genotypical changes for acquiring cell migration, invasion, attachment properties etc. These steps can be partially/fully mimicked under in vivo and in vitro conditions. Here, we injected metastatic prostate cancer cell line, DU145, into the chorioallantoic membrane )CAM( of the chicken embryo to generate sublines which were isolated 7-days post-injection, and subcultured under in vitro conditions. Our results showed that one of these sublines, DC-1-, exhibited a distinctive phenotype compared with the parental cell line when grown in 3D culture model. Further, the expression of Tks4 at the mRNA and protein level in DC-1- cells was observed to be higher than the regular DU145 cells. Keywords: Prostate cancer, DU145, DC-1-, Metastasis, Round, Stellate, Colony, Tks4
Outcomes of Resection Surgery in Corrosive Esophageal Stricture
Authors: Ijaz Hafsa , Arshad Saad , Qureshi Uzair Ahmed , Tayyab Muhammad Azam , Alvi Abdul Rehman , Ameen Imran
Published: November 2022

Background: Esophageal stricture is a rarely encountered but a significant issue of worry throughout the world. Treatment options for esophageal stricture include endoscopic dilatation and surgery along with proton pump inhibitors. Surgery is performed if there is failure of enough dilatation and if recurrence occurs despite multiple dilatations. Objective: This study was designed to determine the outcome of resection surgery in adult patients presenting with Corrosive Esophageal Strictures. Material and Methods: A descriptive cross sectional study was carried out at surgery department, DHQ hospital Gujranwala, from December 2019 to June 2020. 60 consecutive patients, of age 20-60 years of either gender with presence of esophageal strictures caused by intake of corrosive substances and failed to undergo endoscopic dilatation due to difficulty in passing endoscope across the esophageal stricture, were included in the study. All study participants underwent resection surgery procedure under general anesthesia by a single surgical team. The marginal arcade alongside colon was conserved in all cases in which colon was utilized. Feeding jejunostomy was placed in all patients. Duration of surgery was noted. After surgery, patients were followed-up in surgical wards for 48 hours and examined on ultrasound for cervical anastomotic leak. Then patients were followed-up in OPD for 15 days and if dysphagia reoccurred, it was also noted. Results: The mean age of patients was 31.80 ± 7.74 years. There were 47(78.3%) male and 13(21.7%) female cases. There were 33.3% case who took acid, 16.7% took alkalis, 16.7% cases ingested metal salts, 21.7% had formalin, 6.7% cases had iodine tincture and 5.0% cases had other types of corrosive material. The mean operative time was 3.80 ± 0.80 hours. There were 11(18.3%) cases who had cervical anastomotic leak and 10(16.7%) cases had dysphagia related problem. No statistically significant difference (p≥0.05) was found in the outcomes of resection surgery across various groups based on age, gender, BMI, duration of corrosive intake, and type of corrosive substance ingested. Also, No significant difference (p≥0.05) was found in mean operative time in any stratum. Conclusion: It is concluded that outcome of resection surgery in adult patients presenting with Corrosive Esophageal Strictures was favorable with less complications. Hence these cases can be managed with standard surgical procedure to save their life and improve the quality of life. Keywords: Corrosives, Esophageal Stricture, Resection Surgery, Dysphagia, Cervical Anastomotic leak
Gestão de resíduos plásticos: uma aplicação prática das mídias sociais na disciplina de educação ambiental
Authors: Oliveira Larissa Anadir Carneiro de , Silva Rodrigo de Cássio da , Fragoso Rosimeri de Oliveira
Published: November 2022

Cada vez mais tecnologias como as mídias sociais estão sendo introduzidas no ambiente escolar/institucional, alterando os métodos tradicionais de ensino e abrindo novos horizontes para práticas inovadoras. Diante disso, objetivou-se verificar como a mídia social Instagram pode ser utilizada como instrumento facilitador dentro da disciplina de Educação Ambiental, auxiliando tanto didaticamente como na construção de valores e referenciais ambientais acerca da importância da correta gestão dos resíduos plásticos. Para tanto, foram produzidos materiais educativos sobre o tema “gestão de resíduos plásticos”, os quais foram inseridos no perfil do Instagram do projeto de extensão “Diário de um resíduo” da Universidade Estadual de Ponta Grossa e trabalhados com os alunos da disciplina durante os períodos de aula. Conclui-se que o uso de mídias sociais como o Instagram pode ser considerado uma prática eficiente na promoção do ensino dos alunos da disciplina de Educação Ambiental. Ressalta-se o potencial das mídias sociais em expandir a aprendizagem para além da sala de aula, podendo se tornar um importante subsídio à Educação Ambiental, visando o desenvolvimento de ações concretas voltadas à preservação ambiental.
Integridade na Pesquisa no âmbito da conjuntura pandêmica de COVID-19: um mapeamento bibliométrico
Authors: Santos-d'Amorim Karen
Published: November 2022

Introdução: apresenta um mapeamento bibliométrico sobre o tema “integridade na pesquisa” com foco nas discussões da produção científica publicada no âmbito do cenário originado pela pandemia de COVID-19. Método: os dados para este estudo bibliométrico, de natureza exploratória quanto aos fins, e quali-quantitativa quanto aos métodos, foram coletados em 08 de dezembro de 2021 na base de dados Scopus, contemplando artigos publicados de 2020 até a data do levantamento. Na condução da estratégia de busca foram incluídos sinônimos para “integridade científica” e para “COVID-19”. Resultados: publicados em 78 diferentes periódicos, os 106 artigos que compuseram o corpus da pesquisa compreenderam 128 assuntos associados ao tema de análise. Somados, esses artigos acumulam 1.018 citações, revelando também o interesse da comunidade no tema em pesquisas subsequentes. Duas principais frentes de pesquisa foram percebidas no mapeamento: a primeira, direcionada a desafios éticos no campo da saúde, da pesquisa clínica, médica e biomédica, e a segunda, relacionada a vulnerabilidade trazida pela pandemia em curso, que deu margens a mudanças em processos de revisão por pares, que, consequentemente possibilitaram a publicação (e a posterior retratação) de pesquisas imprecisas, defeituosas e com baixo rigor metodológico, trazendo prejuízos ao sistema da comunicação científica, como também influenciando opinião pública a partir da divulgação de casos de má conduta. Conclusão: identifica que a promoção da integridade na pesquisa, por meio da publicação de artigos no tema, tem sido parte da agenda de pesquisa ao redor do globo.
A participação dos cidadãos na promoção da biodiversidade urbana - o projeto biodivercities em Valongo, Portugal
Authors: Isidoro Catarina , Mota José Carlos , Seixas Desirée , Moreira Gil
Published: November 2022

Este artigo tem como objetivo discutir o potencial e as limitações das metodologias de envolvimento dos cidadãos na promoção da biodiversidade urbana a partir do desenvolvimento do projeto europeu Biodivercities em Valongo, dinamizado pelo Município de Valongo em colaboração com o Laboratório de Planeamento e Políticas Públicas da Universidade de Aveiro.  O BiodiverCities é um projeto inserido no contexto da Estratégia de Biodiversidade da UE que tem como objetivo aumentar a participação da sociedade civil na tomada de decisão na construção das cidades verdes do futuro.  Face ao crescimento dos aglomerados urbanos e à urgência de combater a crise climática e alcançar as metas estabelecidas para um desenvolvimento sustentável, têm vindo a surgir este tipo de iniciativas à escala europeia que assumem que a mudança de comportamentos tem de ser co-construída por decisores políticos, especialistas e cidadãos. Assim, a metodologia adotada assenta no envolvimento dos cidadãos, responsáveis políticos, técnicos municipais e atores locais na implementação de micro-laboratórios de biodiversidade, nos quais se irão ensaiar de forma participada e colaborativa novas formas de compreender e valorizar a diversidade biológica do ecossistema natural e urbano. Neste artigo, faz-se um enquadramento das temáticas da biodiversidade urbana e participação da comunidade, relata-se o processo de implementação e discute-se os resultados e limitações deste projeto.
Application of Biocom-Phosphate Solubilizing Fungi and Coal Fly-Ash to Increase P-Availability of Peat Soil in Kalimantan
Authors: Ichriani Gusti Irya , Ifansyah Hairil , Maulana Agus , Fauwziah Ema Rizki , Syifa Muhammad , Lautt Bambang Supriyono , Jaya Adi , Chusnul Chotimah Hastin Ernawati Nur , Pasaribu Wiranda
Published: November 2022

The peatlands have the potential to support food security efforts. However, there is have constraints on soil fertility, especially the P nutrients availability. The biotechnology approach, the application of ameliorant (biochar-compost carrier medium (biocom)) enriched with phosphate solubilizing fungi (PSF) and coal fly ash (CFA), was expected to increase the P-availability in peat soils. The research aimed to study the application of biocom enriched with PSF and CFA to increase soil P-availability and plant P-uptake. The study was conducted using peat soil media with the formulation of CFA and biocom enriched with PSF and CFA as treatments. The treatment effect was observed through soil P available and plant P uptake of maize. The results showed PSF application was inconsistent in improving P available in peat soils in Kalimantan. In Central Kalimantan, Biocom + PSF was able to increase P available in peat soils by up to 406.18% (A. oryzae-Tb7) and 353.44% (N. fischeri-Tm8). However, in South Kalimantan P available in peat soil was only 8.04% (A. oryzae-Tb7) and 12.86% (N. fischeri-Tm8). The CFA+ (biocom+PSF) formulation increased P available in Central Kalimantan peat soils, but it was different from South Kalimantan peat soils. The application of biocom+PSF and CFA has not been able to increase the P uptake of maize plant in peatlands of South Kalimantan.
EVALUATION OF LOWER GASTROINTESTINAL BLEEDING RISK ASSOCIATED WITH USE OF LOW DOSE ASPIRIN
Authors: AZIZ MF , KHAN AR , BASHIR A
Published: November 2022

To evaluate risk of aspirin related lower gastrointestinal bleeding a Prospective study was performed at Department of medicine, Nishtar Hospital, Multan from July 2019 to January 2020. Total 372 patients using low dose aspirin were selected from out-patient department of Medicine. All patients underwent diagnostic laboratory test for stool examination. A consultant pathologist confirmed presence or absence of lower gastrointestinal bleeding. Data including age, gender, history of bleeding per rectum, blood on stools, BMI, duration of aspirin use, and reason for aspirin prescription was recorded. The study was conducted on 372 patients, 120 (32.3%) were female while 252 (67.7 %) were male. Mean age of the patients was 40 years. Mean duration of use of low dose aspirin was 22.23 ± 16.59 months. Lower gastrointestinal bleeding was noted in 81 (21.8%). Use of dose aspirin is significantly associated with lower gastrointestinal bleeding. Clinicians must anticipate adverse effects in such patients.
Quantitative survey of medicinal plants in six medicinal plant conservation areas of Uttarakhand, India
Authors: Naithani Harsh
Published: November 2022

Non-Timber Forest Produce (NTFPs) as medicinal and aromatic plants provide convenient and easy source of income for rural people. Due to human interference, over exploitation and indiscriminate harvest, IUCN, WWF and others have red listed them. FRLHT along with State Forest Department in India established in-situ conservation sites of medicinal plants known as Medicinal Plants Conservation Areas (MPCAs). Due to the richness of medicinal plants, the state of Uttaranchal (now Uttarakhand) in 2003 was declared as ‘Herbal State’. Under UNDP-GEF-GOI funded project for long term conservation and sustainable use of medicinal plants, seven MPCAs were selected in Uttarakhand. Out of seven, six MPCAs were sampled by the author using nested quadrates technique for sampling of medicinal plants.
STUDY OF THE SOCIO-ECONOMIC FACTORS INFLUENCE ON THE ELDERLY RUSSIANS HEALTH LEVEL
Authors: Кислая С.С. , Трегуб И.В.
Published: November 2022

В статье представлены результаты исследования факторов здоровья россиян старших возрастов. Информационной базой исследования являются данные репрезентативного опроса «Российский мониторинг экономического положения и здоровья населения (RLMS-HSE)» за 2021 г. Объектом исследования являются индивиды в возрасте 60 лет и старше (согласно классификации Всемирной организации здравоохранения, они отнесены к категории пожилых). Авторами предложено в качестве характеристики состояния здоровья пожилого индивида использовать число групп хронических заболеваний. По результатам оценивания модели множественной линейной регрессии определено, что ключевыми детерминантами здоровья населения старших возрастов выступают как социально-экономические и демографические факторы, так и субъективная оценка собственного здоровья.

The paper presents the results of a study of the older Russians health factors. The research is based on The Russia Longitudinal Monitoring Survey – Higher School of Economics (RLMS-HSE) representative data for 2021. The object of the study are individuals aged 60 years and older (according to the WHO classification they belong to the elderly category). The authors proposed to use the number of chronic diseases groups as a characteristic of the elderly individual health status. Based on the results of the multiple linear regression model estimation, it was found that the key determinants of the elderly population health are both objective factors, as well as a subjective assessment of their own health.
Predicting Hospital Readmissions After Total Shoulder Arthroplasty Within a Bundled Payment Cohort
Authors: Pezzulo Joshua D. , Farronato Dominic M. , Rondon Alexander J. , Sherman Matthew B. , Getz Charles L. , Davis Daniel E.
Published: November 2022

Introduction:

Given the rising demand for shoulder arthroplasty, understanding risk factors associated with unplanned hospital readmission is imperative. No study to date has examined the influence of patient and hospital-specific factors as a predictive model for 90-day readmissions within a bundled payment cohort after primary shoulder arthroplasty. The purpose of this study was to determine predictive factors for 90-day readmissions after primary shoulder arthroplasty within a bundled payment cohort.

Methods:

After obtaining IRB approval, a retrospective review of a consecutive series of Medicare patients undergoing primary shoulder arthroplasty from 2014 to 2020 at a single academic institution was conducted. Patient demographic data, surgical variables, medical comorbidity profiles, medical risk scores, and social risk scores were collected. Postoperative variables included length of hospital stay, discharge location, and 90-day readmissions. Multivariate analysis was conducted to determine the independent risk factors of 90-day readmission.

Results:

Overall, 3.6% of primary shoulder arthroplasty patients (127/3,523) were readmitted within 90 days. Readmitted patients had a longer hospital course (1.75 versus 1.45 P = 0.006), higher comorbidity profile (4.64 versus 4.24 P = 0.001), higher social risk score (7.96 versus 6.9 P = 0.008), and higher medical risk score (10.1 versus 6.96 P < 0.001) and were more likely to require a home health aide or be discharged to an inpatient rehab facility or skilled nursing facility (P = 0.002). Following multivariate analysis, an elevated medical risk score was associated with an increased risk of readmission (odds ratio = 1.05, P < 0.001).

Discussion:

This study demonstrates medical risk scores to be an independent risk factor of increased risk of 90-day hospital readmissions after primary shoulder arthroplasty within a bundled payment patient population. Additional incorporation of medical risk scores may be a beneficial adjunct in preoperative prediction for readmission and the potentially higher episode-of-care costs.

Level of Evidence:

Level III, retrospective cohort.
Efektivitas Model Pembelajaran Problem Solving dan Problem Based Learning Ditinjau Kemampuan Berpikir Kritis Siswa
Authors: Puspitawati Yayuk , Mawardi Mawardi
Published: November 2022

Seiring dengan kebutuhan siswa yang semakin kompleks. Dibutuhkan suatu cara serta strategi dalam melaksanakan pembelajaran oleh seorang guru. Salah satu terobosan penting sebagai upaya dalam rangka meningkatkan hasil belajar yang dilakukan oleh seorang guru yaitu problem solving dan problem Based Learning. Tujuan penyusunan karya ini yaitu untuk memperoleh suatu pengetahuan tentang keefektifan sistem pembelajaran problem solving dan problem Based Learning lagi kemampuan berpikir kritis peserta didik SD. Penulisan pada karya ini menggunakan metode eksperimen. Untuk itu matching pretest-post-test comparison group design bagian dari desain karya ini. 23 siswa adalah bagian dari sampel dalam karya ini dengan cara probability sampling melalui cluster sampling. Observasi dilakukan guna untuk memperdalam pengamatan kegiatan pembelajaran siswa di kelas Serta adanya suatu tes yang dilakukan di kelas dalam rangka cara penulis untuk memperoleh data. Dan kuantitatif bagian dari cara untuk mendapatkan analisa data. Hasil dalam penelitian ini adalah terdapat efektivitas pembelajaran tematik problembased learning terhadap kemampuan berpikir kritis pembelajaran tematik peserta didik kelas 5 SD.
Somos o que consumimos ou consumimos o que somos? A simbologia no ato de consumir da sociedade capitalista
Authors: Alves Maciel Mitali Daian , TROIAN ALESSANDRA , Freddo Fleck Carolina , Garcia Machado Nunes Alessandra
Published: November 2022

O ato de consumir adquiriu distintos sentidos e relações, que extrapolam o significado econômico, traduzindo-se em um acontecimento, sobretudo social. Nesse sentido, o estudo tem como objetivo analisar os sentidos e significados incorporados à ação de consumir na sociedade capitalista. Baseando-se em três bases argumentativas: por meio de Veblen, estudou-se a presença de instituições, especialmente hábitos mentais enraizados socialmente como mecanismo para a determinação do consumo conspícuo; a partir de Bourdieu, analisou-se as relações entre o consumo e as classes sociais, com a visão que investiga grupos de status, distinção e simbologia no ato de consumir; e através do olhar de Bauman, vislumbra-se que o consumo deixou de ser o elemento de inclusão, refletindo-se, em uma sociedade de consumidores. Assim, percebe-se que o consumo, que garante prestígio e os usos atribuídos aos objetos e a velocidade de troca, tornaram-se definidores do pertencimento a uma elite, da inclusão e exclusão social.