bluuebunny/crossref_metadata_2025 huggingface dataset:
Iron metabolism and lymphocyte subpopulations during Covid-19 infection in ICU patients: an observational cohort study and a narrative review of clinical practice.
Authors: Bolondi Giuliano , Russo Emanuele , Gamberini Emiliano , Circelli Alessandro , Meca Manlio Cosimo Claudio , Brogi Etrusca , Viola Lorenzo , Bissoni Luca , Poletti Venerino , Agnoletti Vanni
Published: May 2020

Background: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. Little is known about clinical management of severe forms of Covid-19. Methods: we performed an observational study during the peak of pandemic in our intensive care unit, serially dosing D-dimer, C-reactive protein, Troponin T, Lactate Dehydrogenase, Ferritin, Serum iron, Transferrin, Transferrin Saturation, Transferrin Soluble Receptor, Lymphocyte count and NK, CD3, CD4, CD8, B subgroups of 31 patients during the first two weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with Spearman coefficient and Mann-Whitney test. Trend over time were tested with Kruskall-Wallis analysis. Results: All patients show hyperferritinemia, and its dosage might be helpful in individuating patients developing hemophagocytic lymphohistiocytosis (we observed 1 case). Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 109/L; interquartile range (IQR) 0.450 109/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. Neither Ferritin nor lymphocyte count follow significant trends in ICU patients. Transferrin Saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at day 3 to 6 (median 33%, IQR 26.5%, p-value 0.026). The same trend is observed with serum iron levels (median 25.5 µg/L, IQR 69 µg/L at admission; median 73 µg/L, IQR 56 µg/L on day 3 to 6) without reaching statistical significance. D-dimer is constantly elevated and progressively increases from admission (median 1319 µg/L; IQR 1285 µg/L) to day 3 to 6 (median 6820 µg/L; IQR 6619 µg/L), despite not reaching significant results. We describe trends of all the above mentioned parameters during ICU stay and provide a narrative review of our clinical experience about critical Covid-19 patients. D-dimer is constantly elevated in our ICU population and increases from admission to a maximum on day 3 to 6 of ICU stay (median 6820 µg/L; IQR 6619 µg/L) Conclusions: iron metabolism and lymphopenia are key clinical features of Covid-19 patients in the ICU setting and have been specifically described in this paper. Keywords – MeSH repository (3-10): Iron, COVID-19, SARS-CoV-2, Coronavirus, Critical Care, Lymphocytes, Lymphopenia, Ferritins, Immunity, Coagulation.
DNA methylation patterns–based subtype distinction and identification of soft tissue sarcoma prognosis
Authors: Wu Zhengyuan , Yu Miao , Fan Jing-yuan , Wen Zhen-pei , Ren Tian-yu , Yao Jun , Li Jia
Published: May 2020

Background: Soft tissue sarcomas (STSs) are heterogeneous at the clinical with a variable tendency of aggressive behavior. Methods: In this study, we constructed a specific DNA methylation-based classification to identify the distinct prognosis-subtypes of STSs based on the DNA methylation spectrum from the TCGA database.Results: Eventually, samples were clustered into four subgroups, and their survival curves were distinct from each other. Meanwhile, the samples in each subgroup reflected differentially in several clinical features. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was also conducted on the genes of the corresponding promoter regions of the above‐described specific methylation sites, revealing that these genes were mainly concentrated in certain cancer‑associated biological functions and pathways. In addition, we calculated the differences among clustered methylation sites and performed the specific methylation sites with LASSO algorithm. The selection operator algorithm was employed to derive a risk signature model, and a prognostic signature based on these methylation sites performed well for risk stratification in STSs patients. At last, a nomogram consisted of clinical features and risk score was developed for the survival prediction. Conclusion: In conclusion, this study declares that DNA methylation-based STSs subtype classification is highly relevant for future development of personalized therapy as it identifies the prediction value of patient prognosis.
Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma
Authors: Theelen Willemijn , Krijgsman O , Monkhorst K , Kuilman T , Peters DDGC , Cornelissen S , Ligtenberg M , Willems SM , Blaauwgeers JLG , Noesel CJM van , Peeper DS , Heuvel MM van den , Schulze K
Published: May 2020

The authors have removed this preprint from Research Square.
Radiological features of Central Giant Cell Granuloma: Comparative study of 7 case reports and literature review
Authors: Shrestha Samip , Zhang Jia , Yan Jun , Zeng Xiaomin , Peng Xiaoyong , He Bo
Published: May 2020

Background: To review and analyze the clinical and imaging features of central giant cell granuloma patients and to review the relevant literatures for the diagnosis and clinical manifestation of central giant cell granuloma.Methods: 7 cases of central giant cell granuloma were retrospectively selected for the study all of which were confirmed by pathology and had relevant imaging investigations. All 7 cases had undergone CT scan, 3 cases had undergone MRI scan. Detailed clinical features were compared along with the imaging findings and analysis was done on the basis of their presentation and imaging features.Results: The clinical features, radiologic features were varied according to the site of the lesion. CT features include unevenly dense expansile mass causing bone destruction and cortical thinning. While MRI features with low to iso-intensity in T1 weighted and T2 weighted images. There may be presence of cystic degeneration, hemorrhage or hemosiderin deposits or osteoid formation, which can cause T1 and T2 signal changes. On contrast study, the lesion doesn’t enhance but periphery may enhance mildly. Conclusion: Unevenly dense expansile mass with bone destruction and cortical thinning with low to iso-intensity in T1 weighted and T2 weighted images and mildly enhance peripherally, CGCG should be considered.
The Potential of CBC-Derived Ratios (Monocyte-to-Lymphocyte, Neutrophil-to-Lymphocyte, and Platelet-to-Lymphocyte) to Predict or Diagnose Incident TB Infection in Tanzanian Adolescents
Authors: Rees Christiaan , PINEROS Dwan , AMOUR Maryam , MUNSERI Patricia , SAID Jamila , MAGOHE Albert , MATEE Mecky , PALLANGYO Kisali , VON REYN C Fordham
Published: May 2020

Background: Ratios of different immune cell populations ( i.e., monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte ratios) have been studied as a means of predicting future tuberculosis (TB) disease risk or to assist in the diagnosis of incident TB disease. No studies to-date, however, have evaluated the potential of these ratios to predict or assist in the diagnosis of incident TB infection - the first step in the natural history of TB disease.Methods: In this prospective study, we evaluated the complete blood count (CBC)-derived metrics of monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) as predictors of future TB infection risk or aids in the diagnosis of TB infection among 145 Tanzanian adolescents enrolled in the DAR-901 vaccine trial, using paired CBCs and interferon-gamma release assays (IGRAs) obtained at 0, 60 and 720 days after study enrollment.Results: At baseline, there were no significant differences between study participants who remained persistently IGRA negative throughout the study period and those who subsequently converted to IGRA positive with respect to MLR (0.18 vs 0.17, p =0.10), NLR (0.88 vs 1.02, p =0.08), or PLR (115 vs 120, p =0.28). Similarly, no significant differences were noted with respect to MLR, NLR, and PLR between IGRA converters and time-matched negative controls at the time of IGRA conversion. With respect to other blood cell measures, however, there were modest but significant differences between IGRA negatives and IGRA converters with respect to red blood cell count (4.8 vs 4.5 × 10 6 cells/mcL, p =0.008), hemoglobin (12.6 vs 12.3 g/dL, p =0.01), and hematocrit (38.8 vs 37.8%, p =0.005).Conclusions: In contrast to prior studies that have suggested that the ratios of different immune cell populations are associated with development of TB disease, our present findings do not demonstrate an association between these ratios and the development of TB infection. However, decreased red blood cell measures were associated with the subsequent development of TB infection, suggesting that dysregulation of iron metabolism may play a role in TB pathogenesis.Trial Registration: Data presented are from clinical trial NCT02712424.
Clinical Characteristics and Cardiovascular Implications of 116 Hospitalized Patients with COVID-19 in Wuhan, China: A single-Centered, Retrospective, Observational Study
Authors: Xiong Shiqiang , Liu Lin , Lin Feng , Shi Jinhu , Han Lei , Liu Huijian , He Lewei , Jiang Qijun , Wang Zeyang , Fu Wenbo , Li Zhigang , Lu Qing , Chen Zhinan , Ding Shifang
Published: May 2020

Background Corona Virus Disease 2019 (COVID-19) caused by 2019 novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged population with cardiovascular diseases are more likely be to infected with SARS-CoV-2 and result in more severe outcomes and elevated case-fatality rate. Meanwhile, cardiovascular diseases have a high prevalence in the middle-aged and elderly population. However, despite of several researches in COVID-19, cardiovascular implications related to it still remains largely unclear. Methods 116 patients with laboratory-confirmed COVID-19 were enrolled, who admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020. The demographic data, underlying comorbidities, clinical symptoms and signs, laboratory findings, chest computed tomography, treatment measures, and outcome data were collected from electronic medical records. Data were compared between non-severe and severe cases.Results Of 116 hospitalized patients with COVID-19, the median age was 58.5 years (IQR, 47.0-69.0), and 36 (31.0%) were female. Hypertension (45 [38.8%]), diabetes (19 [16.4%]), and coronary heart disease (17 [14.7%]) were the most common coexisting conditions. Common symptoms included fever [99 (85.3%)], dry cough (61 [52.6%]), fatigue (60 [51.7%]), dyspnea (52 [44.8%]), anorexia (50 [43.1%]), and chest discomfort (50 [43.1%]). Lymphopenia (lymphocyte count, 1.0 × 109/L [IQR, 0.7-1.3]) was observed in 66 patients (56.9%), and elevated lactate dehydrogenase (245.5 U/L [IQR, 194.3-319.8]) in 69 patients (59.5%). Compared with non-severe cases, severe cases were older (64.0 years [IQR, 53.0-76.0] vs 56.0 years [IQR, 37.0-64.0]), more likely to have comorbidities (35 [63.6%] vs 24 [39.3%]), and more likely to develop acute cardiac injury (19 [34.5%] vs 4 [6.6%]), acute heart failure (18 [32.7%] vs 3 [4.9%]), and ARDS (20 [36.4%] vs 0 [0%]). During hospitalization, the prevalence of new onset hypertension was significantly higher in severe patients (55.2% vs 19.0%) than in non-severe ones. Conclusions We found that the infection of SARS-CoV-2 was more likely to occur in aged population with cardiovascular comorbidities. Cardiovascular complications, including new onset hypertension and heart injury were common in severe patients. More detailed researches in cardiovascular involvement in COVID-19 are urgently needed to further understand the disease.
Dynamic arterial elastance during experimental endotoxic septic shock
Authors: García Manuel Ignacio Monge , González Pedro Guijo , Orduña Paula Saludes , Romero Manuel Gracia , Cano Anselmo Gil , Messina Antonio , Rhodes Andrew , Cecconi Maurizio
Published: May 2020

Background: Dynamic arterial elastance (Ea dyn ), the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a functional parameter that is a surrogate of arterial load. We aimed to determine the effects of endotoxic septic shock and hemodynamic resuscitation on Ea dyn . Results: Experimental randomized study in a university animal research laboratory with 18 New Zealand rabbits. Animals received placebo (SHAM, n=6) or intravenous lipopolysaccharide (LPS, Escherichia coli serotype 055:B5, 1 mg·kg -1 ) with or without (EDX-R, n=6; EDX-NR, n=6) hemodynamic resuscitation (fluid bolus of 20 ml·kg -1 and norepinephrine for restoring mean arterial pressure). Continuous arterial pressure and aortic blood flow measurements were obtained simultaneously. Cardiovascular efficiency was evaluated by the oscillatory power fraction (%Osc: oscillatory work / left ventricular (LV) total work) and the energy efficiency ratio (EER = LV total work/cardiac output). The LPS-induced endotoxic shock produced a hyperdynamic shock with high cardiac output and arterial hypotension. Ea dyn increased in septic animals (from 0.73 to 1.70; p=0.012) and dropped after hemodynamic resuscitation. Ea dyn was related with the %Osc and EER [estimates: -0.101 (-0.137 – -0.064) and -9.494 (-11.964 – -7.024); p<0.001, respectively]. So, the higher the Ea dyn, the better the cardiovascular efficiency (lower %Osc and EER). Conclusions: In this experimental model, Ea dyn increased during endotoxic septic shock and decreased with hemodynamic resuscitation. Sepsis resulted in a reduced oscillatory power fraction and lowered EER, reflecting a better cardiovascular efficiency that was tracked by Ea dyn . Ea dyn could be a potential index of cardiovascular efficiency during septic shock.
Anti Hepatitis C virus drugs show potential drug repositioning for SARS CoV-2 main protease: an in silico study
Authors: Anandamurthy Arthikasree , Varughese Roslin Elsa , Sivaraj Saranya , Dasararaju Gayathri
Published: May 2020

Developing effective and safe vaccines/drugs against SARS CoV-2 may take some time. The urgency of the outbreak has led to the usage of broad spectrum of existing anti-viral drugs, across the globe. Among the existing anti-viral drugs, there is still a challenge in identifying the potent drug or the combination of the drugs for the better treatment and faster recovery of the patients. In silico molecular docking study aids in the process of drug repurposing and we aimed to identify the binding potential of some of the existing anti-viral drugs and their interactions at the active site of SARS CoV-2 main protease. Results from our study revealed that the drugs Simeprevir, Elbasvir, Paritaprevir, Beclabuvir, Dasabuvir, Teleprevir, Velpatasvir, Ombitasvir, Ledipasvir, Boceprevir, Asunapervir, Declatasvir, Sofusbuvir which are used in the treatment of Hepatitis C virus infection may act as potent inhibitors for SARS CoV-2 main protease.
Rapid Genomic Characterization of SARS-CoV-2 Viruses From Clinical Specimens Using Nanopore Sequencing
Authors: Li Jun , Wang Haoqiu , Mao Lingfeng , Yu Hua , Yu Xinfen , Sun Zhou , Qian Xin , Cheng Shi , Chen Shuchang , Chen Junfang , Pan Jingcao , Shi Jueliang , Wang Xuchu
Published: May 2020

The outbreak of the novel SARS-CoV-2 has swiftly spread worldwide. Rapid genome sequencing of the SARS-CoV-2 strains has become a helpful tool for better understanding of virus genomic characteristics and the origin. To obtain the virus whole-genome sequence directly from the clinical specimens, we performed the nanopore sequencing using a modified ARTIC protocol on portable nanopore sequencer, and validated the routine 8 hours workflow and 5 hours rapid pipeline. We had made some optimizations to improve the genome sequencing workflow. The sensitivity of the workflow was also tested by serially diluting RNA from clinical samples. The optimized pipeline was finally applied to obtain the whole genomes from 17 clinical specimens in Hangzhou from January 2020 to March 2020. In the obtained 17 complete genomes of SARS-CoV-2, 12 variations were found and analyzed. The genomic variations and phylogenetic analysis hinted the multiple sources and different transmission pattern during the COVID-19 epidemic in Hangzhou, China. In conclusion, the genomic characteristics and the origin of the virus could be quickly determined by nanopore sequencing following our workflows.
Posttraumatic stress disorder (PTSD), anger and Mental health of school students in Syria after ten years of conflict: a large scale school-based study
Authors: Kakaje Ameer , Zohbi Ragheed Al , Alyousbashi Ayham , Abdelwahed Rawan N. K. , Aldeen Osama Hosam , Alhalabi Mohammad Marwan , Ghareeb Ayham , Latifeh Youssef
Published: May 2020

The Syrian crisis has entered its tenth year with incessant conflicts in many locations across Syria. Much of the population have been impacted including children who suffer the direct and indirect war effects of war. To date there has been no large scale study examining the mental health and academic impacts of the war of children in Syria. This large-scale cross-sectional study aims to evaluate the psychological profile of school students in Damascus Syria examining PTSD, anger and general mental health and examine their relationships with work, smoking and academic performance. The study included 1369 students from seven different schools. Surveys included assessment of mental and physical well-being using a measure of health related quality of life (SF8), Posttraumatic stress disorder (CRIES-13), problematic anger (DAR5) smoking, working habits, social support and academic grades. The study found that more than half of the children suffered from PTSD (53%), problematic anger (62%) with this being associated with poorer SF-8 (quality of life) scores in both mental and physical domains and more time watching TV and Internet. Around 46% declared fair or worse general health and 61% having moderate or severe mental health. War variables had an impact on PTSD, anger, and SF-8, but not an impact on grades. Worse HRQL was associated with war variables and smoking. Social support was negatively correlated with SF-8, PTSD, DAR-5 anger and declarations of close friends being the main source of support. This is the largest study of children is Syria to date that reports on the psychological ramification of war. The study demonstrates the severe impact on children across both mental health and physical health. Although direct war effect could not be observed, the high burden of PTSD and anger distress is a strong reflection of the chronic mental trauma. School students have had to work and face many hurdles in a young age which has left them severely impacted.
B cell clonal expansion and convergent antibody responses to SARS-CoV-2
Authors: Nielsen Sandra C. A. , Yang Fan , Hoh Ramona A. , Jackson Katherine J. L. , Roeltgen Katharina , Lee Ji-Yeun , Rustagi Arjun , Rogers Angela J. , Powell Abigail E. , Kim Peter S. , Wang Taia T. , Pinsky Benjamin , Blish Catherine A. , Boyd Scott D.
Published: May 2020

During virus infection B cells are critical for the production of antibodies and protective immunity. Establishment of a diverse antibody repertoire occurs by rearrangement of germline DNA at the immunoglobulin heavy and light chain loci to encode the membrane-bound form of antibodies, the B cell antigen receptor. Little is known about the B cells and antigen receptors stimulated by the novel human coronavirus SARS-CoV-2. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of V genes, and extensive activation of IgG and IgA subclasses without significant somatic mutation. We detect expansion of B cell clones as well as convergent antibodies with highly similar sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. A shared convergent B cell clonotype in SARS-CoV-2 infected patients was previously seen in patients with SARS. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.
Availability of workplace policy for prevention of coronavirus disease 2019 and its relationship with personal protection behaviours: A survey of employees
Authors: WANG Kailu , WONG Eliza Lai Yi , HO Kin Fai , CHEUNG Annie Wai Ling , YEOH Eng Kiong , CHAN Emily Ying Yang , WONG Samuel Yeung Shan
Published: May 2020

Background: The evolving pandemic of coronavirus disease 2019 (COVID-19) has become a severe threat to public health, and the workplace presents high risks in terms of spreading the disease. Few studies have focused on the impact of workplace policy on individual behaviours. This study aimed to examine the relationship of workplace guidelines and measures with employees’ behaviours regarding COVID-19 prevention. Methods: A cross-sectional survey using an online questionnaire was conducted to gather employees’ access to workplace guidelines and measures as well as their personal protection behaviours. Statistical associations between these two factors in different occupations were examined using multiple ordinal logistic regressions. Results: A total of 1048 valid questionnaires across five occupational groups were analysed. Manual labourers reported lower availability of workplace guidelines and measures (76.9% vs. 89.9% for all, P = 0.003). Employees with available workplace guidelines and measures performed personal protection behaviours with higher frequency, and this association was more significant among managers/administrators and manual labourers. Conclusions: Awareness about the disease and pandemic among employers and administrators should be promoted, and resources should be allocated to publish guidelines and implement measures in the workplace. Manual labourers may require specific attention regarding accessibility of relevant information, given their poorer experience of workplace policy and their work nature. Governments should guide the establishment of appropriate policies and responses at the workplace level. Further studies are needed to test the effectiveness of specific workplace policies on COVID-19 prevention.
Two case reports of COVID-19: A 6-year-old boy and his 66-year-old grandmother
Authors: Yi Wanwan , Fan Hengwei , Lv Zhong Wei , Long Xuan , zhu hengmei
Published: May 2020

Background: Currently, COVID-19 is a global pandemic disease that has caused a large number of infections worldwide. Reports of COVID-19 cases are not uncommon, but there is no report that SAMS-CoV-2 RNA test results for grandma and grandchildren in family aggregation infections are completely different.Case presentation: A 6-year-old boy's chest CT indicated lung infection, but SAMS-CoV-2 RNA test was negative. His grandmother's imaging showed lung inflammation absorption, and nucleic acid test was positive. Conclusions: Children and the elderly people have different clinical manifestations during the course of SAMS-CoV-2 infection, it is challenging to identify whether they are infectious. Therefore, the diagnosis of COVID-19 requires a combination of multiple detection measures, including clinical features, imaging features, and SAMS-CoV-2 RNA test results.Keywords: COVID-19; SAMS-CoV-2 RNA test; Imaging diagnosis; Case report
O NOVO ESTATUTO DA PESSOA COM DEFICIÊNCIA E SUAS REPERCUSSÕES NO CASAMENTO E UNIÃO ESTÁVEL
Authors: RODRIGUES Rafaela Amaral , MELO FILHO Renato Luis
Published: May 2020

O objetivo principal deste trabalho é estudar como o novo Estatuto da Pessoa com Deficiência influenciou no Código Civil e Código Processo Civil, principalmente em relação ao casamento e à união estável dos deficientes e suas as principais características, pois tal Estatuto trouxe ampla autonomia e igualdade para as pessoas com deficiência, com o propósito de fazer jus à dignidade da pessoa humana. Portanto, com a plena capacidade para os atos civis, houve a oportunidade de os deficientes constituírem matrimônio e união estável, conforme será tratado nesta pesquisa.
A MITIGAÇÃO DO ARTIGO 5º, LXXVIII DA CONSTITUIÇÃO FEDERAL: UMA REFLEXÃO SOBRE A CELERIDADE NO PROCESSO CIVIL
Authors: LUCHESI Rafael Silva , NOVAES Elizabete Cristiane de Oliveira Futami de
Published: May 2020

O tema desta pesquisa tem como espoco a reflexão sobre a eficácia do artigo 5º, LXXVIII, da Constituição Federal brasileira e a delimitação do tema é o estudo da efetividade do princípio da celeridade processual. Os objetivos são compreender o referido princípio como forma de mitigar a morosidade judiciária, ao analisar a celeridade, suas vertentes, e sua relação com os demais princípios basilares no direito processual civil. A metodologia consistiu em revisão de literatura, documentos e comparativos de todos os materiais encontrados, capazes de analisar as diretrizes indagadas na pesquisa. Em suma, a problemática abordada dispõe sobre a falta de celeridade, em razão do fator cultural arraigado à sociedade, que recorre ao Judiciário antes de buscar uma solução extrajudicial do conflito e à falta de cooperação entre os sujeitos do processo, que culmina em uma marcha processual morosa.
Procyclicality mitigation for initial margin models with asymmetric volatility
Authors: Goldman Elena , Shen Xiangjin
Published: May 2020

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The Development of a Scale to Evaluate Foreign Language Skills at Preparatory Schools
Authors: ARSLAN Recep Şahin
Published: May 2020

The aim of the present study is to develop a valid and reliable scale evaluating the effectiveness of language preparatory programs in the acquisition of language skills. In the development of Foreign Language Skills Scale (FLSS) in this study, research sample consisted of 326 preparatory school students for the exploratory factor analysis (EFA) and 350 preparatory school students for the confirmatory factor analysis (CFA). Based on the data obtained from the first sample, an EFA was carried out on the FLSS. EFA has identified that 27 items of the scale have factor loads between 0.519 and 0.729, while they explain 65.376% of the total variance and are distributed under five factors. These factors are named as writing skill, speaking skill, listening skill, core skills, and reading skill. A CFA was applied on the data obtained from the second sample that consisted of 350 students. As a result of the CFA, it was confirmed that the FLSS consisted of 27 items and five factors. For all the items in the scale, item-subscale, item-test correlation coefficients and mean differences between the upper and the lower 27% of the participants were calculated, and it is determined that each item is consistent with not only the subscale it is under but also the whole test. In addition, the Cronbach’s Alpha reliability coefficients of the total scale’s and five sub-scales’ internal consistency is quite high. The FLSS is expected to offer a comprehensive evaluation of the acquisition of four language skills in foreign language teaching programs.
Information geometry in quantum field theory: lessons from simple examples
Authors: Erdmenger Johanna , Grosvenor Kevin , Jefferson Ro
Published: May 2020

Motivated by the increasing connections between information theory and high-energy physics, particularly in the context of the AdS/CFT correspondence, we explore the information geometry associated to a variety of simple systems. By studying their Fisher metrics, we derive some general lessons that may have important implications for the application of information geometry in holography. We begin by demonstrating that the symmetries of the physical theory under study play a strong role in the resulting geometry, and that the appearance of an AdS metric is a relatively general feature. We then investigate what information the Fisher metric retains about the physics of the underlying theory by studying the geometry for both the classical 2d Ising model and the corresponding 1d free fermion theory, and find that the curvature diverges precisely at the phase transition on both sides. We discuss the differences that result from placing a metric on the space of theories vs.~states, using the example of coherent free fermion states. We compare the latter to the metric on the space of coherent free boson states and show that in both cases the metric is determined by the symmetries of the corresponding density matrix. We also clarify some misconceptions in the literature pertaining to different notions of flatness associated to metric and non-metric connections, with implications for how one interprets the curvature of the geometry. Our results indicate that in general, caution is needed when connecting the AdS geometry arising from certain models with the AdS/CFT correspondence, and seek to provide a useful collection of guidelines for future progress in this exciting area.
The Quality of the Home Environments of Young Children with Disabilities
Authors: SUCUOGLU Bulbin , AVCİ Kerem , ÖZTÜRK Naciye , BEKTAŞ Nursel
Published: May 2020

This study aimed to analyze the home environment of young children with disabilities. Data related to overall
home environment was collected from 145 mothers by using the Turkish Form of the Home Screening
Questionnaire (HSQ-T), while the home learning environment including the involvement of the mothers and the
learning materials available in the home was assessed through individual interviews with mothers. The finding
revealed that the 50.35 percent of the children live in low-quality homes and whereas the remainders live in
high-quality homes based on the cut-off points of the HSQ-T score. The HSQ-T scores were found to be
significantly related to parental involvement, education level and income of the mothers, and the developmental
functions of the children measured by the Abilities Index. The mothers who live in less crowded homes
participated in activities with their children more than those in the other group. Additionally, a comparison of the
home quality of CWDs with and without access to home-made toys revealed a significant difference in the HSQ-
T scores of the two groups of children, and finally, the maternal involvement was found to be the main predictor
of the home environment of children.
Strategi Komunikasi Dakwah Wilayatul Hisbah dalam Pencegahan Pelanggaran Qanun Aceh tentang Jinayat di Aceh Barat
Authors: Nurjanah Nurjanah
Published: May 2020

Wilayatul Hisbah responded to the high level of violations of the Qanun Jinayat in Aceh. The process of minimizing violations is carried out through the propaganda communication strategy. This article aims to find the communication strategy of preaching Wilayatul Hisbah West Aceh in preventing violations of the Aceh Qanun Number 6 of 2014 concerning Jinayat. The method used is qualitative-descriptive. Data collection techniques carried out by observation, interviews and documentation. The results showed that the Wilayatul Hisbah missionary communication strategy was a communicator strategy, a message strategy, a media strategy, and an effect strategy.

Wilayatul Hisbah merespon tingginya tingkat pelanggaran Qanun Jinayat di Aceh. Proses meminimalisir pelanggaran dilakukan melalui strategi komunikasi dakwah. Artikel ini bertujuan untuk menemukan strategi komunikasi dakwah Wilayatul Hisbah Aceh Barat dalam pencegahan pelanggaran Qanun Aceh Nomor 6 Tahun 2014 tentang Jinayat. Metode yang digunakan adalah kualitatif-deskriptif. Teknik pengumpulan data dilakukan dengan  observasi, wawancara dan dokumentasi. Hasil penelitian menunjukkan strategi komunikasi dakwah Wilayatul Hisbah adalah strategi komunikator, strategi pesan, strategi media, dan strategi efek.
Reformulasi Metode Dakwah bi al-Lu’bah sebagai Trauma Healing pada Anak Korban Bencana Alam
Authors: Soebahar Moh Erfan , Ghoni Abdul
Published: May 2020

The use of the da'wah bi al lu'bah method can be implemented for children affected by natural disasters. The formulation of the da'wah method can be done by combining the da'wah method with the trauma healing technique. This research was conducted with a literary approach and supported by trauma healing activities at the 2006 earthquake site, namely Klaten District - Central Java and Sleman District - Yogyakarta. In fact researchers did not find the practice of da'wah at these two earthquake locations. The results of the study reveal the formulation of bi al lu'bah propaganda can be done in three ways, namely First, infiltration of propaganda material in the existing game. Infiltrate (infiltration) in the game commonly done by mad'u. Second, making da'wah games, can be done in various ways understood by mad'u children. Third, make poetry about propaganda material through popular songs that can be easily remembered.

Penggunaan metode dakwah bi al lu’bah dapat dilaksanakan untuk anak-anak korban bencana alam. Formulasi metode dakwah ini dapat dilakukan dengan penggabungan antara metode dakwah dengan teknik trauma healing. Penelitian ini dilakukan dengan pendekatan literer dan didukung dengan kegiatan trauma healing di lokasi gempa tahun 2006, yaitu Kabupaten Klaten – Jawa Tengah dan Kabupaten Sleman – Yogyakarta. Kenyataannya peneliti tidak menemukan praktik dakwah di dua lokasi gempa ini. Hasil penelitian mengungkapkan formulasi dakwah bi al- lu’bah dapat dilakukan dengan tiga cara, yaitu Pertama, penyusupan materi dakwah pada permainan yang ada.  Menyusupkan (infiltrasi) pada permainan yang lazim dilakukan oleh mad’u. Kedua, membuat permainan dakwah, Membuat permainan dakwah dapat dilakukan dengan berbagai cara yang dipahami oleh mad’u anak. Ketiga, membuat syair tentang materi dakwah melalui lagu-lagu populer yang dapat mudah diingat.
Dakwah Humanis melaui Gerakan Tarekat
Authors: Moehson Qomariah
Published: May 2020

Humanist propaganda is one way of da'wah with the aim of making humanity. Tarekat is a religious activity which is important for Muslims to draw closer to Allah SWT. The purpose of this study is to analyze the da'wah process through tarekat activities which are considered to have strategic content values in making Muslims better. This study was conducted with a phenomenological qualitative approach. The results of this study reveal that preaching activities through tarekat are good Da'wah choices. The goodness of da'wah through the tarekat is seen as more about the target, where the members of the tarekat are more concerned about their whereabouts, at the same time the members or congregations are also given da'wah material in accordance with their wishes and existence.

 

Dakwah humanis merupakan salah satu cara dalam berdakwah dengan tujuan lebih menjadikan manusia secara lebih manusiawi. Tarekat merupakan sebuah kegiatan keagamaan yang dipandan penting bagi umat Islam dalam mendekatkan diri kepada Allah SWT. Tujuan penelitian ini melakukan analisis terhadap proses dakwah melalui kegiatan tarekat yang dipandang mempunyai nilai kandungan strategis dalam menjadikan umat Islam menjadi lebih baik. Studi ini dilakukan dengan pendekatan kualitatif fenomenologis. Hasil penelitian ini mengungkapkan bahwa kegiatan dakwah melalui tarekat merupakan pilihan dakwah yang baik. Kebaikan dakwah melalui tarekat dipandang lebih mengenai pada sasaran, dimana anggota tarekat lebih diperhatikan keberadaannya, sekaligus para anggota atau jamaah tarekat juga diberi materi dakwah yang sesuai dengan keinginan dan keberadaan dirinya.   
Pengaruh E-Servicescape terhadap Trust dan Dampaknya pada Repurchase Intention
Authors: Oebit Zakwannur
Published: May 2020

Penyedia jasa transportasi online menciptakan aplikasi dengan berbagai fitur demi kenyamanan konsumen. Setiap aplikasi memiliki ciri khas tampilan yang merupakan lingkungan tempat konsumen melakukan transaksi, selanjutnya disebut e-servicescape dalam penelitian ini.

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh dari dimensi e-servicescape terhadap kepercayaan dan minat konsumen melakukan pemesanan ulang suatu jasa. Objek penelitian adalah layanan pesan antar makanan pada aplikasi mobile yang bernama GO-FOOD. Sampel penelitian ini adalah 400 responden yang pernah melakukan pembelian produk melalui GO-FOOD di wilayah Jabodetabek yang didapat dengan teknik penarikan sampel purposive sampling.

Variabel yang digunakan dalam penelitian ini didasarkan pada tiga dimensi berdasarkan kerangka e-servicescape, yaitu: aesthetic appeal, layout and functionality, dan financial security. Variabel ini diuji untuk mengidentifikasi apakah variabel tersebut mempengaruhi variabel kepercayaan konsumen (trust) yang mengarah pada variabel minat melakukan pembelian ulang (repurchase intention). Teknik analisis data yang digunakan dalam penelitian ini adalah Covariance Based Structural Equation Modelling (CB-SEM).

Seluruh hipotesis terbukti positif dan didukung dalam penelitian ini. E-servicescape secara signifikan berpengaruh positif terhadap Trust dan selanjutnya secara signifikan berpengaruh positif terhadap repurchase intention. Hasil penelitian ini dapat menjadi rujukan bagi pengembang aplikasi mobile serta bagi penelitian lebih lanjut di bidang yang sama.
E-Supply Chain Management Value Concept for The Palm Oil Industry
Authors: Akbar Muhamad , Darius Antoni
Published: May 2020

The Harmony of IT and Business is an asset and the foundation of the organizations to improve and build business competitive strategies. There is a need to integrate and coordinate all business partners of the organization, particularly those associated with Information Technology and suppliers, raw materials or resources needed in the supply chain management. The effectiveness of an E-SCM in Palm Oil industry will be the crucial factor to provide the organization with business opportunities and improve competitive position in the marketplace. Aim of this study is to investigates critical factors E -Supply Chain Management in Oil Palm Industry through Theory Resource Based View (RBV).  With RBV theory, this study develops a concept that can be utilized for identifying the critical success factors of E-SCM value in Palm Oil industry. The quantitative research method is used for collecting data in four Palm Oil organizations in South Sumatera. This research reveals that IT human resources and IT infrastructure are the critical factors and capability in to operate E-SCM effectively and
Influence Factors of Social Media and Gadget Addiction of Adolescent in Indonesia
Authors: Pratama M. Octaviano , Harinitha Dwi , Indriani Susmini , Denov Bryan , Mahayana Dimitri
Published: May 2020

Social media user in Indonesia has growth rapidly since its emergence. In 2019, one of largest social media platform, Facebook has 3 billion users world wide user and 130 million users of them come from Indonesia. Moreover, the other social media like Instagram also has significantly growth with most of user are teenagers. Massive social media usage was caused by more than 100 million active users that use gadget or smartphone to open application like social media. Both of widely social media and gadget usage is not only have possitive impact but also negative impact like mental and behaviour problem if the user has been addicted. Hence the requirement of knowing influence factors of social media and gadget addiction in Indonesia is required in order to prevent addiction of social media and gadget. In this paper, the influence factors of social media and gadget addiction in Indonesia is investigated using several techniques like data science, partial least square, and structural equation modelling
Effectiveness of Perineal Massage in the Second Stage of Labor in Preventing Perineal Trauma
Authors: Oglak Suleyman Cemil , Obut Mehmet
Published: May 2020

OBJECTIVE: This study was aimed to investigate the effect of perineal massage in the second stage of labor in prevention perineal traumas during childbirth.STUDY DESIGN: This observational study was conducted with 171 nulliparous women delivered by vaginally between January 2017 and May 2019. All the patients managed by the selective episiotomy principle. All the patients were divided into two groups: the perineal massage group and the control group. The perineal massage was performed during the second stage of labor until the baby's head was birth. The control group received routine labor care. In the case of threatening tears in any patient and at the preference of the midwife, mediolateral episiotomy was performed. Following childbirth, the perineum and vagina were examined for perineal tears and episiotomy by the midwives.RESULTS: The length of the second stage of labor was significantly lower in the massage group (36±19 minute) compared with the control group (46±25 minute, p=0.024). Twenty-five women (28.8%) in the massage group had intact perineum after vaginal birth, compared with five (6.0%) in the control group (p=0.003). The rate of first- and second-degree perineal tears are higher in the massage group [28 patients (32.2%) and 9 patients (10.3%), respectively] than in the control group [10 patients (11.9%) and 5 patients (6.0%), respectively, p<0.001]. The incidence of episiotomy was significantly lower in the massage group (25 patients, 28.7%) than in the control group (64 patients, 76.1%, p<0.001). CONCLUSION: Perineal massage should be considered a routine intervention to reduce the incidence of perineal trauma.
Targeted Drug Therapy to Overcome Chemoresistance in Triple-negative Breast Cancer
Authors: Kumari Mamta , Krishnamurthy Praveen Thaggikuppe , Sola Piyong
Published: May 2020

Triple-negative Breast Cancer (TNBC) is the most aggressive and prevailing breast cancer
subtype. The chemotherapeutics used in the treatment of TNBC suffer from chemoresistance,
dose-limiting toxicities and off-target side effects. As a result, conventional chemotherapeutics are
unable to prevent tumor growth, metastasis and result in failure of therapy. Various new targets such
as BCSCs surface markers (CD44, CD133, ALDH1), signaling pathways (IL-6/JAK/STAT3, notch),
pro and anti-apoptotic proteins (Bcl-2, Bcl-xL, DR4, DR5), hypoxic factors (HIF-1α, HIF-2α) and
drug efflux transporters (ABCC1, ABCG2 and ABCB1) have been exploited to treat TNBC. Further,
to improve the efficacy and safety of conventional chemotherapeutics, researchers have tried to deliver
anticancer agents specifically to the TNBCs using nanocarrier based drug delivery. In this review,
an effort has been made to highlight the various factors responsible for the chemoresistance in
TNBC, novel molecular targets of TNBC and nano-delivery systems employed to achieve sitespecific
drug delivery to improve efficacy and reduce off-target side effects.
Green Solvent: Green Shadow on Chemical Synthesis
Authors: Sahoo Tejaswini , Panda Jagannath , Sahu Jnanaranjan , Sarangi Dayananda , Sahoo Sunil K. , Nanda Braja. B. , Sahu Rojalin
Published: May 2020

The natural beauty and purity of our planet has been contaminated deeply due to human selfish
activities such as pollution, improper waste management, and various industrial and commercial discharges of
untreated toxic by-products into the lap of nature. The collective impact of these hazardous suspensions into
the natural habitat is very deadly. Challenges due to human activity on the environment have become
ubiquitous. The chemical industry has a major role in human evolution and, predictably, opened gates of
increased risk of pollution if the production is not done sustainably. In these circumstances, the notion of Green
Chemistry has been identified as the efficient medium of synthesis of chemicals and procedures to eradicate the
toxic production of harmful substances. Principles of Green Chemistry guide the scientist in their hunt towards
chemical synthesis which requires the use of solvents. These solvents contaminate our air, water, land and
surrounding due to its toxic properties. Even though sufficient precautions are taken for proper disposal of
these solvents but it is difficult to be recycled. In order to preserve our future and coming generation from the
adverse impacts associated with solvents it is very important to find alternative of this which will be easy to
use, reusable and also eco-friendly. Solvents are used daily in various industrial processes as reaction medium,
as diluters, and in separation procedures. As reaction medium, the role of solvent is to bring catalysts and
reactants together and to release heat thus affecting activity and selectivity. The proper selection of the solvent
considering its biological, physical and chemical properties is very necessary for product separation,
environmental, safety handling and economic factors. Green solvents are the boon in this context. They are not
only environmentally benign but also cost effective. The biggest challenge faced by the chemists is adaptation
of methods and selection of solvents during chemical synthesis which will give negligible waste product and
will remain human and nature friendly. During designing compounds for a particular reaction it is difficult to
give assurance regarding the toxicity and biodegradability of the method. Chemists are still far away from
predicting the various chemical and biological effects of the compounds on the back of the envelope. To
achieve that point is formidable task but it will definitely act as inspiration for the coming generation of
chemists. The green solvents are undoubtedly a far better approach to eliminate the negative impacts and
aftermath of any chemical synthesis on the environment. Our study in this review covers an overview of green
solvents, their role in safer chemical synthesis with reference to some of the important green solvents and their
detail summarization.
Continuous Hypoxia and Glucose Metabolism: The Effects on Gene Expression in Mcf7 Breast Cancer Cell Line
Authors: Al Bawab Abdel Q. , Zihlif Malek , Jarrar Yazan , Sharab Ahmad
Published: May 2020

Background:

Hypoxia (deprived oxygen in tissues) may induce molecular and genetic
changes in cancer cells.

Objective:

To Investigate the genetic changes of glucose metabolism in breast cancer cell line (MCF7)
after exposure to continuous hypoxia (10 and 20 cycles exposure of 72 hours continuously on a weekly
basis).

Methods:

Gene expression of MCF7 cells was evaluated using real-time polymerase chain reactionarray
method. Furthermore, cell migration and wound healing assays were also applied.

Results:

It was found that 10 episodes of continuous hypoxia activated the Warburg effect in MCF7
cells, via the significant up-regulation of genes involved in glycolysis (ANOVA, p value <0.05). The
molecular changes were associated with the ability of MCF7 cells to divide and migrate. Interestingly,
after 20 episodes of continuous hypoxia, the expression glycolysis mediated genes dropped significantly
(from 30 to 9 folds). This could be attributed to the adaptive ability of cancer cells.

Conclusion:

It is concluded that 10 hypoxic episodes increased the survival rate and aggressiveness of
MCF7 cells and induced the Warburg effect by the up-regulation of the glycolysis mediating gene
expression.
Efektivitas Penggunaan Video Pembelajaran dalam Meningkatkan Motivasi dan Hasil Belajar Siswa Dalam Pembelajaran Front Office di Kelas XI Akomodasi Perhotelan SMKN 3 Garut
Authors: Irwanto Irwanto
Published: May 2020

Penelitian ini bertujuan untuk mengetahui penggunaan media video terhadap motivasi dan hasil belajar siswa. Pendekatan penelitian yang digunakan adalah pedekatan kuantitatif dengan Metode penelitian Quasi Experimental Design, yaitu desain penelitian eksperimen,dengan tehnik pengumpulan data menggunakan tes dan observasi.  Berdasarkan hasil analisis data, diperoleh kesimpulan bahwa penggunaan video pembelajaran sangat efektif untuk meningkatkan motivasi dan hasil belajar siswa dalam pembelajaran Front Office di Kelas XI Akomodasi Perhotelan SMKN 3 Garut. Hal ini ditunjukan dengan adanya perbedaan antara motivasi dan hasil belajar siswa  antara kelas yang menerapkan media video dengan kelas yang diberikan media video pembelajaran. 

Kata Kunci: Video Pembelajaran, Motivasi, Belajar, Front Office