bluuebunny/crossref_metadata_2025 huggingface dataset:
Agreement between Sonographic Features and Fine Needle Aspiration Cytology in the Diagnosis of Thyroid Nodules in a Tertiary Hospital
Authors: Pabalan Danette , Quimbo Ricardo Victorio
Published: June 2024

Objective. Management of thyroid nodules relies on the Thyroid Imaging Recording and Data System (TIRADS) for sonographic findings and the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The proponents aimed to determine the concordance between sonographic TIRADS findings and cytological diagnosis by TBSRTC in the evaluation of malignancy of patients with thyroid nodules.
Methodology. Sonographic and cytology results collected from 2018 to 2022 were obtained to determine whether there is an agreement between TIRADS and TBSRTC findings.
Results. Two hundred sixty-two (262) samples were obtained. Overall accuracy of predicting TIRADS category was highest for echogenic foci. Thyroid nodule distribution was highest for TIRADS 3 and 4 sonographically and TBSRTC II cytologically. There is low agreement between TBSRTC and TIRADS in the categorization of nodules as benign, implying that nodules may show sonographic features suspicious of malignancy despite being categorized as TBSRTC I or II by cytology. However, nodules categorized as TBSRTC III to VI show sonographic features suspicious for malignancy at the very least.
Conclusion. The correctness of TIRADS prediction is highest for echogenic foci although not significantly higher than other parameters. The overall predicting power of TIRADS for the absence of malignancy is high for TIRADS 1 and 2, whereas TIRADS 5 predicts a 31.11% risk of malignancy making it a strong indication for FNAC. However, prediction of malignancy in TIRADS 3 and 4 nodules must be in association with other factors since a significant percentage may turn out to be TBSRTC II.
Evolution of therapy for ALK-positive lung carcinomas: Application of third-generation ALK inhibitors in real clinical practice
Authors: Nasretdinov A. F. , Sultanbaev A. V. , Musin Sh. I. , Menshikov K. V. , Ayupov R. T. , Izmailov A. A. , Serebrennikov G. A. , Askarov V. E. , Feoktistov D. V.
Published: June 2024

Lung cancer is currently a heterogeneous group of diseases, whose heterogeneity is determined not only by its phenotypic, but also by its genetic profile. A special place is occupied by subtypes that have driver mutations. Due to new antitumor agents – small molecule inhibitors – it has become possible to significantly increase patients’ chances of survival. The diagnostic panel most often includes mutations in the EGFR, ALK, ROS1, BRAF genes; somewhat less frequently, genetic changes in MET, KRAS, HER2, NTRK, etc. are determined. This distribution is most likely explained by the availability of appropriate inhibitors. The article provides an overview of different generations of ALK inhibitors known in the Russian Federation, among them the most famous: crizotinib, ceritinib, alectinib and lorlatinib. These drugs are included in the clinical guidelines for the treatment of ALK-positive lung carcinomas of all major oncology societies. The article describes the results of registration studies proving the advantage of ALK inhibitors over standard therapy, including the results of the CROWN study. In this study, the latest generation of ALK inhibitors, lorlatinib, demonstrates superiority over crizotinib, with a 73% reduction in the risk of progression or death and better intracranial response rates. A description of a clinical case of treatment of metastatic lung cancer using the third generation ALK inhibitor lorlatinib is provided. The drug was prescribed in the first line of therapy. The patient’s treatment outcome indicates high efficacy of lorlatinib in the first-line treatment of ALK translocation-positive lung cancer, along with low toxicity. The treatment period has already been more than 70 months and the patient continues therapy at the time of the last control. A complete response to lorlatinib therapy was recorded. During treatment, the following adverse events were recorded: hypertriglyceridemia, grade 1 toxicity, hypercholesterolemia, grade 2 toxicity, increased liver transaminases, grade 1 toxicity.
Prospects for VR Technologies in Education and Social Life
Authors: Kotov Roman , Kryuk Roman , Turov Semen
Published: June 2024

VR-based technologies are in demand in modern education. They create virtual environment and simulate processes similar to real ones. As a result, students can practice actions that form and consolidate the necessary competencies. This article describes the possibilities of using virtual reality to teach food-industry university students to design production sites, e.g., an independent virtual simulation where students could work on their own projects and developments. The proposed technology offers an improved import-substituting software that creates realistic models of food production, e.g., virtual food processing workshops where students could test and improve their skills in dealing with key parameters and technological processes. The program recreates technological solutions in virtual reality, which simplifies, speeds up, and reduces the cost of developing skills in production site design. This application is the most promising direction for VR technology in education. The software product was developed in the VR laboratory of Kemerovo State University. It allows students to design industrial buildings of various sizes, workshops, and production facilities of various capacities, as well as public catering places and their interior, open public spaces, e.g., city parks, etc. The product has a database for storing and using education materials, design blanks, and ready-made 3D models of equipment created in Unreal Engine. The 3D model database contains digital models of real-life devices and equipment used at food industry enterprises. The projects can be displayed in a visual digital environment to study the principles of equipment operation, monitor and change their parameters, and simulate faults and deviations. The database makes it possible to design small enterprises and large industrial complexes for food production in virtual environment.
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies
Authors: Najar Imtiyaz Ahmed , Pamu Sagar , Paul Anushka , Arora Poonam , Kaur Gaganjit , Kumar Manish
Published: June 2024

The article has been withdrawn at the request of the author and the editor of the journal Current Drug Metabolism.

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of their article is transferred to the publishers if and when the article is accepted for publication.
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma
Authors: Zhu Xiaojing , Zhang Zixin , Zhang Jiaxing , Xiao Yanqi , Wang Hao , Wang Mingwei , Jiang Minghui , Xu Yan
Published: June 2024

Aims:

Investigating the impact of stemness-related circadian rhythm disruption
(SCRD) on hepatocellular carcinoma (HCC) prognosis and its potential as a predictor for immunotherapy
response.

Background:

Circadian disruption has been linked to tumor progression through its effect on the
stemness of cancer cells.

Objective:

Develop a novel signature for SCRD to accurately predict clinical outcomes and immune
therapy response in patients with HCC.

Methods:

The stemness degree of patients with HCC was assessed based on the stemness index
(mRNAsi). The co-expression circadian genes significantly correlated with mRNAsi were identified
and defined as stemness- and circadian-related genes (SCRGs). The SCRD scores of samples
and cells were calculated based on the SCRGs. Differentially expressed genes with a prognostic
value between distinct SCRD groups were identified in bulk and single-cell datasets to develop an
SCRD signature.

Results:

A higher SCRD score indicates a worse patient survival rate. Analysis of the tumor microenvironment
revealed a significant correlation between SCRD and infiltrating immune cells.
Heterogeneous expression patterns, functional states, genomic variants, and cell-cell interactions
between two SCRD populations were revealed by transcriptomic, genomic, and interaction analyses.
The robust SCRD signature for predicting immunotherapy response and prognosis in patients
with HCC was developed and validated in multiple independent cohorts.

Conclusions:

In summary, distinct tumor immune microenvironment patterns were confirmed under
SCRD in bulk and single-cell transcriptomic, and SCRD signature associated with clinical outcomes
and immunotherapy response was developed and validated in HCC.
Characterization and In vivo Evaluation of Polymorphic Valnemulin Hydrogen Fumarate
Authors: Xinle Zhu , Li Zhang , Jian Li , Hui Zhao , Jinhua Gu , Hejia Wang
Published: June 2024

Aims:

In the present study, a valnemulin hydrogen fumarate prodrug was characterized,
its stability was compared with valnemulin hydrochloride, and the efficacy was evaluated in Actinobacillus
pleuropneumoniae-induced pneumonia in mice.

Method:

Optical microscopy, X-ray powder diffraction, infrared spectroscopy, and hydrogen nuclear
magnetic resonance spectroscopy were used to study the physical and chemical properties of
the prodrug. The thermal stability was investigated in comparison with valnemulin hydrochloride
to improve the preparation process of valnemulin hydrogen fumarate soluble powder and maximize
its drug effect. Additionally, the efficacy of valnemulin hydrogen fumarate was evaluated in
a challenge-treatment trial in mice using an in vitro antimicrobial susceptibility test.

Results:

The valnemulin hydrogen fumarate had high crystallinity. After light irradiation for 20
days, valnemulin hydrogen fumarate did not degrade, whereas valnemulin hydrochloride did. These
results showed that the valnemulin hydrogen fumarate was stable. At the same dose in drinking
water, the valnemulin hydrogen fumarate was more effective than the reference drug (tiamulin
fumarate) in an Actinobacillus pleuropneumoniae challenge-treatment trial.

Conclusion:

Valnemulin hydrogen fumarate shows excellent potential for application as a veterinary
drug.
Simultaneous Determination of 8 Antioxidants and Free Sulfur Migrating from Container Closure System into Antibody Drug using High Performance Liquid Chromatography
Authors: Xie Yangguo , Zhang Lei , Li Lie , Cheng Ying , Hou Wei , Zhang Zhongli
Published: June 2024

Background: The additives from container closure systems used in biopharmaceuticals,
including antioxidants and vulcanizing agents, may leach into drug products during production or
storage and result in patient exposure. Thus, there is an urgent demand for developing a robust and
sensitive method for the simultaneous determination of these additives.

Method: An approach utilizing vortex-assisted liquid-liquid microextraction coupled with highperformance
liquid chromatography has been developed for the simultaneous determination of 8
antioxidants and free sulfur in biopharmaceutical samples. The extraction parameters, such as the
choice of extraction solvent, HCl volume, vortex time, and disperser solvent, were optimized to ensure
maximum extraction efficiency.

Results: The optimized method was validated successfully, exhibiting acceptable recovery rates
ranging from 89.2% to 109.0%, excellent repeatability (2.9% to 5.1%, n=6), and intermediate precision
(3.7% to 5.9%, n=12), and satisfactory linearity with an R2 value of 1.000 for all the additives.
Additionally, the limits of detection and quantification were determined to be in the range of 1.9–
30.0 μg/L and 7.5–120.0 μg/L, respectively.

Conclusion: The proposed method was effectively applied to the analysis of additives in biopharmaceutical
samples.
Current Aspects of Nanotechnology Based Healing Approaches for
Diabetic Wounds
Authors: Rautela Deepraj Singh , Das Saumya , Mazumder Avijit , Sharma Bhawana , Mishra Rashmi , Singh Gurvinder
Published: June 2024

Diabetic wounds represent a significant clinical challenge due to their chronic nature,
slow healing rates, and susceptibility to infections, often leading to severe complications. Nanotechnology
plays a transforming role in advancing diabetic wound repair therapies. The field of
nanotechnology has shown great promise in the medical field in recent years, offering precise
tools and materials at the nanoscale to address the complexities of diabetic wound management.
The latest breakthroughs in nanomaterial design and fabrication showcase nanoparticles, nanofibers,
and hydrogels tailored to enhance tissue regeneration, promote angiogenesis, and modulate
the wound microenvironment. These engineered materials serve as versatile systems for the regulated
release of cytokines and antimicrobial agents, offering a multifaceted approach to diabetic
wound healing. Nanotechnology enables the growth of smart medication delivery technologies
with accurate targeting and sustained delivery of medicinal substances right to the location of the
wound. Prolonged injuries in hyperglycemic patients are particularly prone to infections, leading
to prolonged healing times and increased morbidity. Some of the nanoscale antimicrobial agents,
such as nanozyme-chitosan-derived hydrogel, silver nanoparticles, and antimicrobial peptides that
exhibit potent bactericidal properties, reduce the risk of infections and associated complications.
Nanosensors and advanced imaging techniques enable real-time monitoring of wound healing
progress. These tools provide clinicians with valuable insights into tissue viability, inflammation
levels, and treatment efficacy, facilitating timely adjustments to therapeutic regimens. This is an
inclusive overview of the current state of nanotechnology for the treatment of diabetic wounds, offering
insights into the promise and challenges of this innovative approach, by harnessing the
unique properties of nanoscale materials and technologies.
The State of Nationalism (SoN): Nationalism and International Conflict
Authors: Powers Kathleen E. , Ko Jiyoung
Published: June 2024

Does nationalism increase the probability of international conflict? An affirmative answer has intuitive appeal: Nationalists promote force to protect their land and people from foreign threats. Research on nationalism in international conflict implicates elites, masses, and political interactions between these actors when asserting its status as a powerful force that raises the risk for interstate wars. Yet both micro- and macro-level evidence cautions against drawing broad conclusions about how nationalism affects conflict. Nationalism sometimes prompts aggression. In other contexts, nationalism produces restraint. Systematic knowledge about how nationalism relates to international conflict therefore requires answers to questions about which nationalisms promote conflict and whose nationalism matters.
This article first reviews theory and evidence about nationalism’s conflict-causing potential. We discuss the microfoundations that link nationalism to foreign policy attitudes before describing research that implicates nationalism as a cause of militarized conflict. Next, we argue that understanding the complex relationships between nationalism and conflict requires theorizing the causal processes that connect various stakeholders’ nationalism to foreign policy outcomes. Moreover, research on identity content suggests that nationalism is compatible with a variety of foreign policy preferences. Throughout, we centre research that features nationalism as a principal independent variable or causal mechanism precipitating conflict.
Any review about nationalism must contend with the delicate matter of conceptualization — the field contains nearly as many definitions for nationalism as articles about nationalism and war. The research we discuss variously describes nationalism as an identity, ideology, or belief, for example. For our purposes, nationalism captures a set of sentiments related to a national group and its superiority. This broad perspective centers the phenomenon implicated in international conflict research.
Developing Malay traditional dance model for preschoolers: Evidence from contextual and content needs
Authors: Zain Azizah , Tajuddin Siti Nor Amalina Ahmad Tajuddin , Ismail Irwan Mahazir , Masnan Abdul Halim , Saerani Muhammad Fazli Taib Saerani , Alim Maisarah Mohd
Published: June 2024

The uniqueness of the Malay dance community should be introduced to the children so that the beauty of the dance movements does not disappear. Therefore, this study analysed preschoolers' content and the contextual needs of developing the traditional Malay dance model. Quantitative studies using this survey method aim to obtain information about the contextual and content of traditional Malay dance models. 125 preschool teachers from the Ministry of Education (MOE) were selected to respond to the questionnaires. The results show that the necessities of the context should inhibit the aspects of creative movement. The results refer to the content aspect of the model of the basic movement elements in the traditional dances of the Malay community that should be taught to the children. The implication of this study from the development of the model helps preschool teachers in the performance of traditional Malay dances.
Development of pedagogical competences for future primary school teachers through distance learning
Authors: Otynshina Galiya , Dusembinova Raifa , Odintsova Svetlana , Aidarbekova Kulzhan , Shaushekova Bayan
Published: June 2024

The aim of this work is to identify effective means of distance learning, aimed at the formation of pedagogical competence among students-teachers. Achievement of the set goal is possible only by applying a number of special methods and approaches, among which dialectical and functional, as well as the method of analysis and synthesis, pedagogical observation, comparison, classification. The article produced a number of important results, including both theoretical and practical bases of the study. The practical value of the article lies in the fact that it can be used both in the form of teaching and methodical material in the process of training future teachers, and on an arbitrary basis by already working educational workers to improve their skills. In subsequent scientific developments it is necessary to determine the evolution of the development of distance-learning means of training teachers, in order to identify their main shortcomings and thus overcome.Tujuan dari pekerjaan ini adalah untuk mengidentifikasi sarana pembelajaran jarak jauh yang efektif, yang ditujukan untuk pembentukan kompetensi pedagogis di antara siswa-guru. Pencapaian tujuan yang ditetapkan hanya dimungkinkan dengan menerapkan sejumlah metode dan pendekatan khusus, di antaranya dialektis dan fungsional, serta metode analisis dan sintesis, observasi pedagogis, perbandingan, klasifikasi. Artikel tersebut menghasilkan sejumlah hasil penting, termasuk landasan teoretis dan praktis dari penelitian tersebut. Nilai praktis dari artikel ini terletak pada kenyataan bahwa artikel ini dapat digunakan baik dalam bentuk pengajaran maupun materi metodis dalam proses pelatihan calon guru, dan secara sewenang-wenang dengan pekerja pendidikan yang sudah bekerja untuk meningkatkan keterampilan mereka. Dalam perkembangan ilmu pengetahuan selanjutnya perlu ditentukan evolusi perkembangan sarana pembelajaran jarak jauh untuk melatih guru, guna mengidentifikasi kekurangan utama mereka dan mengatasinya.
E-learning, assessment competency and academic performance: A structural equation modelling approach
Authors: Chemdghazali Nor Hasnida , Suppian Zahari , Ahmad Hishamuddin , Zaini Syaza Hazwani , Shuib Tajul Rosli
Published: June 2024

E-learning practices and the competency in assessing should facilitate ones’ academic performance. The main purpose of this study is to explore the degree of influence of e-learning practices and competency in assessment on academic achievement of students. This study is a quantitative approach using survey method involving the process of data collection through the administration of constructed instruments.  The population of the study involves student teachers from the three selected universities in Selangor and Perak. Sample selection is made using random sampling technique. 460 student teachers are selected. The questionnaire for e-learning practices is adapted from OLES (Renee, 2011) and for the competency in assessment comes from Zahari (2018). The structural equation modelling (SEM) analysis is used to test the hypothesized relationship. The results show that, e-learning practices, knowledge and skills in assessing and attitude in assessment significantly influence academic achievement of students. E-learning practices has a highest value and a significant standardized regression coefficient with students’ achievement (0.39) followed by skills in assessment (0.27), knowledge in assessment (0.09) and lastly is attitude in assessment (0.08). The core findings of the study have few implications for higher education and practice, measurement and theory development, and future research.
The model of Islamic character education at SMP-SMA Al-Irsyad Al-Islamiyyah boarding school Purwokerto
Authors: Miftahuddin Miftahuddin , Aman Aman , Yuliantri Rhoma Dwi Aria
Published: June 2024

The purpose of this study is to examine the practice of instilling the Islamic character at the SMP-SMA Boarding School Al-Irsyad Al-Islamiyyah Purwokerto and to understand what kind of Islamic model Al-Irsyad aims to cultivate in its students. This study takes the form of qualitative research, involving data collection through observation, interviews, and document analysis. The data which is then analyzed to gain insights into the implementation of character education at Al-Irsyad. The research findings indicate that the formation of Islamic character at the SMP-SMA Boarding School Al-Irsyad Al-Islamiyyah Purwokerto is accomplished through the Islamic Religious Education (PAI), which includes subjects related to ethics (Akhlak), faith (Aqidah), jurisprudence (Fiqih), and Islamic history (Tarikh Islam). The ethics subject aims to cultivate honesty, integrity, and noble character in students, while discouraging qualities like jealousy. Islamic history delves into the life of Prophet Muhammad (peace be upon him) to provide students with a role model. On the other hand, specific objectives are intended to be cultivated through the instruction of Aqidah (Belief) material. The Aqidah content guides students to abstain from practices within the religion of Islam perceived as deviating from and undermining monotheism, such as acts of polytheism, tawassul, and tabarruk. Given this understanding, it is reasonable for Al-Irsyad to consider it inappropriate to "respect the flag" and observe "moments of silence" during flag-raising ceremonies. Similarly, singing the patriotic song "Padamu Negeri" is prohibited, as all of these actions are seen as deviating from Islamic beliefs.
Investigation of Public Acceptance of Misinformation Correction in Social Media Based on Sentiment Attributions: Infodemiology Study Using Aspect-Based Sentiment Analysis
Authors: Ma Ning , Yu Guang , Jin Xin
Published: June 2024

Background

The proliferation of misinformation on social media is a significant concern due to its frequent occurrence and subsequent adverse social consequences. Effective interventions for and corrections of misinformation have become a focal point of scholarly inquiry. However, exploration of the underlying causes that affect the public acceptance of misinformation correction is still important and not yet sufficient.

Objective

This study aims to identify the critical attributions that influence public acceptance of misinformation correction by using attribution analysis of aspects of public sentiment, as well as investigate the differences and similarities in public sentiment attributions in different types of misinformation correction.

Methods

A theoretical framework was developed for analysis based on attribution theory, and public sentiment attributions were divided into 6 aspects and 11 dimensions. The correction posts for the 31 screened misinformation events comprised 33,422 Weibo posts, and the corresponding Weibo comments amounted to 370,218. A pretraining model was used to assess public acceptance of misinformation correction from these comments, and the aspect-based sentiment analysis method was used to identify the attributions of public sentiment response. Ultimately, this study revealed the causality between public sentiment attributions and public acceptance of misinformation correction through logistic regression analysis.

Results

The findings were as follows: First, public sentiments attributed to external attribution had a greater impact on public acceptance than those attributed to internal attribution. The public associated different aspects with correction depending on the type of misinformation. The accuracy of the correction and the entity responsible for carrying it out had a significant impact on public acceptance of misinformation correction. Second, negative sentiments toward the media significantly increased, and public trust in the media significantly decreased. The collapse of media credibility had a detrimental effect on the actual effectiveness of misinformation correction. Third, there was a significant difference in public attitudes toward the official government and local governments. Public negative sentiments toward local governments were more pronounced.

Conclusions

Our findings imply that public acceptance of misinformation correction requires flexible communication tailored to public sentiment attribution. The media need to rebuild their image and regain public trust. Moreover, the government plays a central role in public acceptance of misinformation correction. Some local governments need to repair trust with the public. Overall, this study offered insights into practical experience and a theoretical foundation for controlling various types of misinformation based on attribution analysis of public sentiment.
Artificial Intelligence in Dental Education: Opportunities and Challenges of Large Language Models and Multimodal Foundation Models
Authors: Claman Daniel , Sezgin Emre
Published: June 2024

Instructional and clinical technologies have been transforming dental education. With the emergence of artificial intelligence (AI), the opportunities of using AI in education has increased. With the recent advancement of generative AI, large language models (LLMs) and foundation models gained attention with their capabilities in natural language understanding and generation as well as combining multiple types of data, such as text, images, and audio. A common example has been ChatGPT, which is based on a powerful LLM—the GPT model. This paper discusses the potential benefits and challenges of incorporating LLMs in dental education, focusing on periodontal charting with a use case to outline capabilities of LLMs. LLMs can provide personalized feedback, generate case scenarios, and create educational content to contribute to the quality of dental education. However, challenges, limitations, and risks exist, including bias and inaccuracy in the content created, privacy and security concerns, and the risk of overreliance. With guidance and oversight, and by effectively and ethically integrating LLMs, dental education can incorporate engaging and personalized learning experiences for students toward readiness for real-life clinical practice.
Pengaruh crowdsourcing dan representasi koleksi terhadap kredibilitas informasi pada museum di Indonesia
Authors: Wibowo Edi , Salim Tamara Adriani
Published: June 2024

Introduction. This research analyzes the influence of crowdsourcing and representation on the credibility of museum information in Indonesia. The aim of the research is to identify the effect of crowdsourcing on credibility, the effect of representation on credibility, the effect of crowdsourcing and representation on credibility.
Data Collection Methods. This research used a quantitative approach to test the relationship between three variables, namely the crowdsourcing variable (X1) and representation (X2) and the credibility variable (Y). The data collection method used a questionnaire distributed to museum managers who have implemented the crowdsourcing concept.
Data Analysis. The research results were processed using SPSS v26. Analysis models used were Descriptive Analysis, Classic Assumption Test, Regression Test, Correlation T Test, F Test, and Coefficient of Determination.
Results and Discussion. The research results show: 1) crowdsourcing has a positive effect on credibility. 2) representation has a positive effect on credibility. 3) crowdsourcing and representation have a positive effect on credibility
Conclusion. The three variables have a significant influence on each other. Crowdsourcing and collection representation influence the credibility of museum collection information in Indonesia.
Implementasi teori the seven pillars of information literacy sconul dalam menganalisis kemampuan literasi informasi masyarakat Kelurahan Pattallassang
Authors: Lukman Lukman , Hamna Dian Muhtadiah , Azzahra A Nurul Fatimah
Published: June 2024

Introduction. Information literacy is one of the keys to improve the quality of human resources. This study aims to determine the level of information literacy of the Pattallassang Village community and obtain solutions to optimize problems related to information literacy in the community.
Data Collection Methods. We collected the data using a quantitative descriptive approach. The data collection technique was carried out by distributing questionnaires. There were 80 respondents participated as a result of an accidental sampling.
Data Analysis. The research variable used was information literacy skills with indicators of the seven pillars of information literacy theory by the Standing Conference of National and University Libraries. The data analysis technique was descriptive resulted by  the Likert scale.
Results and Discussion. Referring to the seven pillars of information literacy, the average score of Pattallassang Village community information literacy level showed a moderate category. Solutions to optimize the problem, namely community education, is recommended to the government to form community information groups by providing anti-hoax information media platforms.
Conclusion and Suggestion. Implementing information literacy in life is very important in the current era. Research related to information literacy in society needs to be carried out by providing education to support sustainability.
Upaya guru memanfaatkan perpustakaan sekolah sebagai sumber belajar di Sekolah Dasar Negeri Tosanan Ponorogo
Authors: Riyanto Riyanto , Tajab Muh. , Rifan Moh. , Wuryono Wuryono , Nursiah Nursiah , Setyaningrum Krista Alifa , Ridhwan M. Habib Izazur
Published: June 2024

Introduction. The aim of the paper is to understand the efforts of  Islamic education teachers in utilizing the library as one of the school's facilities and infrastructure, at State Elementary School of Tosanan Ponorogo by using the approach of the Association for Education Communication Technology (AECT).
Data Collection Methods. This was a qualitative descriptive with by observations and, structured interviews.
Data Analysis. The interview data was transcribed for analysis.
Results and Discussion. The efforts showing by teacher’s to utilize the school library as a learning resource are shown by improving their quality. These Include how to  absorb  information from the library as teaching, to increase the intensity of visits to the library, to increase the collection/number of books and to make the best use of the existing library facilities.
Conclusions and Recommendations. The library at State Elementary School of Tosanan Ponorogo has not been maximally utilized as a learning resource in every lesson. This library should increase the number of books, support facilities for users and manage library base on standards. For further research it is hoped that it can be expanded, so that it is not limited to Islamic religious education teachers but to teachers of other subjects.
Preservasi naskah kuno Gandoang melalui kegiatan digitisasi
Authors: Khadijah Ute Lies Siti , Khoerunnisa Lutfi , Lusiana Elnovani , Anwar Rully Khairul
Published: June 2024

Introduction. Ancient manuscripts are one of the nation's many cultural heritages with historical significance. As a result, conservation measures must be implemented, one of which is the transfer of digital media. The purpose of this study is to learn about the efforts made to transfer Gandoang ancient manuscripts to Ciamis.
Data Collection Methods. This study employs a qualitative case study approach, with data collected through observation techniques and semi-structured interviews with three informants.
Data Analysis. Through Miles and Hubberman data analysis techniques; researchers organize, organize, and categorize them.
Result and Discussion. The findings of this study indicate that, as part of the management's effort to preserve the Gandoang ancient manuscripts in collaboration with Tapak Karuhun Nusantara Foundation, converting them into a digital form into an e-book can be considered effective and efficient. The ancient manuscripts in this fragile state can now be preserved, allowing their existence to be used for a long time.
Conclusion. Because of the internet, which allows everyone to read it wherever and whenever they want, the Gandoang e-book has proven to be more popular in the public. However, many ancient manuscripts in the Ciamis still require the attention of various parties due to their endangered state.
Peran GLAM dalam pendidikan tinggi untuk pelestarian budaya
Authors: Istiarni Atin , Widayati Jamzanah Wahyu
Published: June 2024

Introduction: This research aims to explore the factors influencing the implementation of GLAM in academic libraries considering technological, organizational and environmental factors.
Method: We used a quantitative approach with Structural Equation Modelling. 91 university librarians in Indonesia responded to the distributed questionnaires.
Data analysis: The data was analysed using Exploratory Factor Analysis.
Results: The most influential factor is technology at 31.31%, obtained from observations to 14 variables. The second influencing factor is organization with a calculation result of 27.10% obtained from the 10 observed variables. The third influencing factor is environment, with a calculation result of 17.3% based on 3 observed variables. The innovation diffusion in the implementation of GLAM in university libraries as an effort to preserve culture however is not yet ready from a technological and organizational perspective. It is noted that environment is the factor with the least influence.
Conclusion: This research uses three factors, namely technology, organization and environment as a theoretical basis for answering problems. Based on the research results, technology is the most influential dominant factor in implementing the GLAM in university libraries. Organization is the second influencing factor, while environment is the third factor.
Analysis and Research on the Integration of Mathematical Culture into Course Ideological and Political Education Cases
Authors: Ding Xiaoye
Published: June 2024

This article starts with mathematical culture and combines classic stories such as Cao Chong's weighing of the elephant and Han Xin's divide of oil. Analyze the ideological and political elements embedded in mathematical culture and effectively integrate them into classroom teaching. So as to achieve a silent effect on moistening things and implement the fundamental task of cultivating virtue and talent. Finally, strategies for classroom teaching are provided to provide some ideas for the reform of ideological and political education in university courses.
Construction of multidisciplinary knowledge and development of socio-emotional skills for meaningful learning in university students: “A methodology to support the teacher in the development of this activity”
Authors: Piceno Yolanda García , Duarte Angélica Castañeda , Nava Miguel Alberto Gutiérrez , Serratos Diana Mireya Hernández
Published: June 2024

The purpose of this article is to show the methodology of a tool for the construction of significant multidisciplinary knowledge, emphasizing the strengthening of socio-emotional skills. We will begin by addressing concepts, the paradigm of constructivism and social constructivism as the basis of the proposed methodology, the differences between the approaches of traditional educational models, critical theory and constructivism. Followed by the methodology, its requirements, results and we will reflect on the results obtained and finally conclusions.
revisión de nanopartículas de oro: características fisicoquímicas y su respuesta celular en macrófagos
Authors: Jiménez-Martínez Williams de Jesús , Vázquez-Lira Juan Carlos
Published: June 2024

El estudio de los nanomateriales (NMs) y sus propiedades fisicoquímicas como tamaño, naturaleza química, composición y forma es de suma importancia. Específicamente las nanopartículas de oro (AuNPs) y sus formas como rodillos, esferas y cubos son utilizados en el ámbito biomédico; por ejemplo, las nanoestrellas y cubos de oro presentan un gran efecto de resonancia del plasmón de superficie localizador (LSPR), permitiendo ser utilizadas en diagnóstico, marcaje y terapias tumorales; sin embargo, estos últimos carecen o tienen pocos estudios toxicológicos in vitro que permiten asegurar su biocompatibilidad. En esta revisión se mencionan las principales características de las AuNPs que permiten usarlas en estas terapias y algunos de los estudios celulares realizados con ellas en cultivos de macrófagos para la obtención de concentraciones adecuadas y su futura aplicación médica.
Nanodispersion of TiO2 in hypochlorous acid and its antimicrobial effect against oral pathogens
Authors: Morales-Noriega Juan Rafael , López-Ayuso Christian Andrea , Acosta-Torres Laura Susana , Manisekaran Ravichandran
Published: June 2024

The continuous and inappropriate use of traditionally used antimicrobial agents has caused the rise of multidrug-resistant (MDR) bacterial strains and the mutation of microorganisms in the field of dentistry. Therefore, various nanoparticles have been developed to combat resistant pathogens. Titanium dioxide (TiO2) nanoparticles have been attractive antimicrobial agents because of their chemical stability, non-toxicity, and inexpensive precursors. Therefore, TiO2-based nanodispersions were explored by preparing them with well-known antimicrobial agents, such as hypochlorous acid (HOCl), to enhance the antimicrobial effect. In this study, sol-gel-based TiO2 NPs-HOCl nanodispersions were synthesized and characterized. The antimicrobial effect was assessed by a microdilution assay using S. mutans, S. aureus,  E. faecalis, and C. albicans strains by incubating different concentrations of the nanodispersions. To evaluate the cytotoxic effects, stem cells from the apical papilla (SCAPs) were inoculated and evaluated using the MTT assay. The nanodispersion exhibited an enhanced antimicrobial effect, with almost no cytotoxicity. The HOCl-based nanodispersion exhibited a greater antimicrobial effect and high stability. Thus, it can be used as a promising antimicrobial agent for the treatment of various dental pathogens.
Cambio agrario y cuestión ambiental en el sureste de la selva Lacandona: Marqués de Comillas en la transición entre los siglos XX y XXI
Authors: Cano Castellanos Ingreet Juliet
Published: June 2024

La complejidad rural en Marqués de Comillas, en el sureste de la selva Lacandona, Chiapas, evidencia la brecha que sigue ampliándose entre los modos de vida de la población y las proyecciones idealizadas de la política pública ambiental. Con base en una trayectoria investigativa de media duración y de corte etnográfico, en este artículo se describe y analiza el proceso de constitución de dicha brecha y los límites de algunas acciones ambientales frente a las realidades locales. Posteriormente, se examinan las incertidumbres socioambientales en el contexto regional y se argumenta la presencia de dificultades para reconocer las tendencias globales de cambio agrario que han permeado en la sociedad rural, una miopía que deriva del actual proceso de desconfiguración y reconfiguración de la política pública ambiental en México.
Performar la nación: Monumento a la Revolución de 1948 en el gobierno de Óscar Osorio (1950-1956)
Authors: Rocha Cortez David José
Published: June 2024

Este texto parte de las ideas de performance y nación para comprender las narrativas y discursos de la Revolución del 48 y del gobierno de Óscar Osorio (El Salvador, 1950-1956). Se explora sobre cuáles fueron los relatos de nación producidos durante el mandato de este presidente y cómo se articularon las estrategias discursivas para proyectar estos relatos en el Monumento a la Revolución. Para responderlas, se parte de la posibilidad epistemológica de los estudios de performance y los estudios teatrales porque permiten vincular acciones de la vida cotidiana y del poder con las obras de arte. Se plantea un recorrido por la noción de performance, posteriormente se exponen algunas ideas sobre la Revolución del 48 para comprender este evento histórico/político, y por último se analizan dos monumentos y las acciones sucedidas en la noche de su inauguración para comprender cómo funcionan los mecanismos performativos sobre el espacio público en relación con el monumento, la nación y el performance del poder.
Multiterritorialidad wixárika: precisiones acerca del espacio compartido y las comunidades wixaritari
Authors: Medina Miranda Héctor
Published: June 2024

El artículo tiene como objetivo revisar las diversas configuraciones territoriales con las que lidian cotidianamente los wixaritari, los procesos históricos que les han conducido hacia la desterritorialización y las estrategias con las que ellos han respondido, creando nuevos territorios comunales que se articulan a través de la tradición ritual. En estas configuraciones, procesos y estrategias están en juego el territorio cosmogónico y el comunal. Lo anterior se lleva a cabo en diálogo con el trabajo del antropólogo Paul Liffman, quien sostiene la existencia de sistemas estatales tributarios wixaritari, originados en los intercambios sacrificiales entre los centros ceremoniales.
Entre la pesadez y la liviandad de ser mujer
Authors: García Bejarano Karim
Published: June 2024

¿Peso o levedad? Es la interrogante que hoy resuena con vigor en mi mente al decidir iniciar con estas líneas y después de haber vivido la experiencia del taller impartido por la Dra. Irene Ballester Buigues.En días previos al evento, me mantuve en mi firme posicionamiento al margen del feminismo y los estudios de género, ya que erróneamente me habían definido el primer concepto de manera tan llana como el significado del ‘machismo’ pero visto como su opuesto; no obstante, nunca lo cuestioné ni lo discutí, ya que esas palabras provinieron de una figura extremadamente importante en aquel momento de mi vida.En el inicio de mi adolescencia poseía esa concepción dada, que a mi parecer denotaba en extremo algunas necedades por parte de una figura femenina de mi entorno familiar cercano para ese lapso de mi existencia; con el paso del tiempo he podido reflexionar sobre varios episodios en los que ella enarbolaba la bandera del feminismo y de acuerdo con lo que ahora conozco del tema, algunos de sus reclamos tenían razón, sin embargo otros tantos también se hallaban en la sinrazón.
El diseño industrial en la economía circular
Authors: García Figueroa Javier , Benítez Luna Rosa María
Published: June 2024

El presente resumen sintetiza el proyecto desarrollado por alumnos y profesores de la Carrera de Diseño Industrial de la Facultad de Estudios Superiores Aragón, que tuvieron dentro de sus objetivos principales aterrizar los conpectosrelacionados al cuidado y respeto del medio ambiente, economía circular y la creación de propuestas de diseño sustentables con alto aporte social.
Protección de Derechos Humanos de las personas con discapacidad
Authors: Morales Sucedo Sandra
Published: June 2024

La protección de los derechos humanos de las personas con discapacidad es un tema importante que se aborda en este artículo. Se presenta una clasificación de los tipos de discapacidad, divididos en grupos y subgrupos. El primer nivel de clasificación incluye cuatro grandes grupos de discapacidad y un grupo de claves especiales. El segundo nivel de clasificación muestra los subgrupos, identificados por una clave de tres dígitos. En relación con la conceptualización de la discapacidad, se ha producido una evolución histórica y normativa. Por último, se exponen conclusiones, en donde se proponen estrategias para lograr un cambio, crítica a la idiosincrasia mexicana así como una al sistema de leyes, ante la poca efectividad de los objetivos planteados como Estado Mexicano.
Los pueblos originarios y la perspectiva que se tiene de ellos en la actualidad
Authors: Morales Franco Andrea Paola
Published: June 2024

A lo largo de la historia mexicana, los pueblos originarios han sido rechazados, violentados y olvidados por la población. Estos han tenido una participación activa en los movimientos sociales más importantes de nuestro país. Sin embargo, la historia se ha encargado de invisibilizarlos y de reducirlos a un grupo que es utilizado meramente con fines políticos.En este ensayo no solo se busca explorar la importancia de los pueblos originarios en la formación de la identidad cultural y la historia de México, sino que se busca hacer un análisis completo de la influencia que tiene este sector de la población sobre todo el país, tanto cultural como políticamente, además de poder recapitular los distintos logros que han tenido después de años de lucha constante contra la violencia sistemática a la que se enfrenta.
Posgrado Programa en Especialización de Puentes, una disciplina fascinante y desafiante
Authors: Zárate Leticia
Published: June 2024

Formar especialistas dedicados a proyectos de infraestructura y en particular obras de ingeniería de puentes, es el objetivo primordial del posgrado Programa en Especialización de Puentes que se imparte en la FES Aragón y cuyo responsable es el Ing. Alfredo Morales.Esta disciplina, nos comparte el Ing. Morales, va enfocada a todos los profesionales que quieran profundizar conocimientos en el área de estudios de proyecto de construcción, proyección, rehabilitación, y en general atender las obras de infraestructura. A diferencia de otros programas, añade, esta especialidad tiene un perfil muy definido: “podríamos hablar de ingeniería en construcción y sabemos que se dedica al área de construcción etc., en este caso es el área de proyecto de puentes, aquí involucramos diferentes campos de la ingeniería, construcción, administración, proyecto, diseño, es la suma de todo para enseñar y que el alumno genere conocimientos para el derrollo de proyecto de puentes”.
modelo peruano de sistema de precedentes. Una propuesta de reconstrucción
Authors: Garcia Yzaguirre Víctor
Published: June 2024

El objetivo del presente artículo es formular una propuesta de análisis del modelo peruano de sistema de precedentes. Ello a efectos de: 1) ofrecer una reconstrucción que sirva como introducción al modelo peruano de sistema precedentes, y 2) ofrecer un esquema de trabajo para las diferentes dogmáticas jurídicas peruanas que les permita presentar y/o profundizar sus discusiones en materia de precedentes.