Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection
Authors: Mukherjee A , Kumar G , Turuk A , Bhalla A , Bingi T C , Bhardwaj P , Baruah T D , Mukherjee S , Talukdar A , Ray Y , John M , Khambholja J R , Patel A H , Bhuniya S , Joshi R , Menon G R , Sahu D , Rao V V , Bhargava B , Panda S ,   The NCRC Study Team, Mishra P , Panchal Y , Sharma L K , Agarwal A , Puri G D , Suri V , Singla K , Mesipogu R , Aedula V S , Mohiuddin M A , Kumar D , Saurabh S , Misra S , Kannauje P K , Kumar A , Shukla A , Pal A , Chakraborty S , Dutta M , Mondal T , Chakravorty S , Bhattacharjee B , Paul S R , Majumder D , Chatterjee S , Abraham A , Varghese D , Thomas M , Shah N , Patel M , Madan S , Desai A , Kala Yadhav M L , Madhumathi R , Chetna G S , Ojha U K , Jha R R , Kumar A , Pathak A , Sharma A , Purohit M , Sarangi L , Rath M , Shah A D , Kumar L , Patel P , Dulhani N , Dube S , Shrivastava J , Mittal A , Patnaik L , Sahoo J P , Sharma S , Katyal V K , Katyal A , Yadav N , Upadhyay R , Srivastava S , Srivastava A , Suthar N N , Shah N M , Rajvansh K , Purohit H , Mohapatra P R , Panigrahi M K , Saigal S , Khurana A , Panchal M , Anderpa M , Patel D , Salgar V , Algur S , Choudhury R , Rao M , Nithya D , Gupta B K , Kumar B , Gupta J , Bhandari S , Agrawal A , Shameem M , Fatima N , Pala S , Nongpiur V , Chatterji S , Mukherjee S , Shivnitwar S K , Tripathy S , Lokhande P , Dandu H , Gupta A , Kumar V , Sharma N , Vohra R , Paliwal A , Pavan Kumar M , Bikshapathi Rao A , Kikon N , Kikon R , Manohar K , Sathyanarayana Raju Y , Madharia A , Chakravarty J , Chaubey M , Bandaru R K , Ali Mirza M , Kataria S , Sharma P , Ghosh S , Hazra A 
Published: August 2022

Objectives

This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC).

Methods

NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined.

Results

Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6–7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4–0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3–0.7)] were protected from in-hospital mortality.

Conclusions

WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality.