bluuebunny/crossref_metadata_2025 huggingface dataset:
Dendritic cell vaccination combined with carboplatin/paclitaxel for metastatic endometrial cancer patients: results of a phase I/II trial
Authors: Koeneman Bouke J. , Schreibelt Gerty , Gorris Mark A. J. , Hins - de Bree Simone , Westdorp Harm , Ottevanger Petronella B. , de Vries I. Jolanda M.
Published: February 2024

Background

Metastatic endometrial cancer (mEC) continues to have a poor prognosis despite the introduction of several novel therapies including immune checkpoints inhibitors. Dendritic cell (DC) vaccination is known to be a safe immunotherapeutic modality that can induce immunological and clinical responses in patients with solid tumors. Platinum-based chemotherapy is known to act synergistically with immunotherapy by selectively depleting suppressive immune cells. Therefore, we investigated the immunological efficacy of combined chemoimmunotherapy with an autologous DC vaccine and carboplatin/paclitaxel chemotherapy.

Study design

This is a prospective, exploratory, single-arm phase I/II study (NCT04212377) in 7 patients with mEC. The DC vaccine consisted of blood-derived conventional and plasmacytoid dendritic cells, loaded with known mEC antigens Mucin-1 and Survivin. Chemotherapy consisted of carboplatin/paclitaxel, given weekly for 6 cycles and three-weekly for 3 cycles. The primary endpoint was immunological vaccine efficacy; secondary endpoints were safety and feasibility.

Results

Production of DC vaccines was successful in five out of seven patients. These five patients started study treatment and all were able to complete the entire treatment schedule. Antigen-specific responses could be demonstrated in two of the five patients who were treated. All patients had at least one adverse event grade 3 or higher. Treatment-related adverse events grade ≥3 were related to chemotherapy rather than DC vaccination; neutropenia was most common. Suppressive myeloid cells were selectively depleted in peripheral blood after chemotherapy.

Conclusion

DC vaccination can be safely combined with carboplatin/paclitaxel in patients with metastatic endometrial cancer and induces antigen-specific responses in a minority of patients. Longitudinal immunological phenotyping is suggestive of a synergistic effect of the combination.
Dwarf minke whales (Balaenoptera acutorostrata) acoustic signals from the South Atlantic Ocean
Authors: Bittencourt Lis , Carvalho Rafael , Santos-Neto Elitieri B. , Bisi Tatiana L. , Lailson-Brito Jose , Azevedo Alexandre F.
Published: February 2024

At present, there are still populations of different balaenopterids that have never been acoustically recorded and observed simultaneously. In an opportunistic sighting of dwarf minke whales during winter in southeastern Brazil, we have registered six individuals and recorded over 200 acoustic signals. Signals were quantified and had their acoustic parameters extracted; the calling rate was estimated as the number of sounds per minute, and the repetition rate was estimated as the number of calls of the same type emitted per minute. Four call types were described: Ba1, Ba2, Ba3 and Ba4. The most common and distinctive call was the Ba1, composed of three components: one had a peak frequency of 615.0 ± 189.8 Hz, and the other had peak frequencies of 1632.0 ± 191.5 and 5038.2 ± 195.1 Hz. Ba1 repetition varied from 2.4 to 11.1 repetitions/min. Ba2 was the second most common call with a peak frequency of 485.2 ± 421.9 Hz. The total calling rate varied from 4.4 to 11.1 calls/min. The signals are in the same frequency range reported for other areas but contain different structures.
Improved prediction of sepsis-associated encephalopathy in intensive care unit sepsis patients with an innovative nomogram tool
Authors: Jin Jun , Yu Lei , Zhou Qingshan , Zeng Mian
Published: February 2024

Background

Sepsis-associated encephalopathy (SAE) occurs as a result of systemic inflammation caused by sepsis. It has been observed that the majority of sepsis patients experience SAE while being treated in the intensive care unit (ICU), and a significant number of survivors continue suffering from cognitive impairment even after recovering from the illness. The objective of this study was to create a predictive nomogram that could be used to identify SAE risk factors in patients with ICU sepsis.

Methods

We conducted a retrospective cohort study using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. We defined SAE as a Glasgow Coma Scale (GCS) score of 15 or less, or delirium. The patients were randomly divided into training and validation cohorts. We used least absolute shrinkage and selection operator (LASSO) regression modeling to optimize feature selection. Independent risk factors were determined through a multivariable logistic regression analysis, and a prediction model was built. The performance of the nomogram was evaluated using various metrics including the area under the receiver operating characteristic curve (AUC), calibration plots, Hosmer-Lemeshow test, decision curve analysis (DCA), net reclassification improvement (NRI), and integrated discrimination improvement (IDI).

Results

Among the 4,476 sepsis patients screened, 2,781 (62.1%) developed SAE. In-hospital mortality was higher in the SAE group compared to the non-SAE group (9.5% vs. 3.7%, p < 0.001). Several variables were analyzed, including the patient’s age, gender, BMI on admission, mean arterial pressure, body temperature, platelet count, sodium level, and use of midazolam. These variables were used to create and validate a nomogram. The nomogram’s performance, assessed by AUC, NRI, IDI, and DCA, was found to be superior to the conventional SOFA score combined with delirium. Calibration plots and the Hosmer-Lemeshow test confirmed the accuracy of the nomogram. The enhanced NRI and IDI values demonstrated that our scoring system outperformed traditional diagnostic approaches. Additionally, the DCA curve indicated the practicality of the nomogram in clinical settings.

Conclusion

This study successfully identified autonomous risk factors associated with the emergence of SAE in sepsis patients and utilized them to formulate a predictive model. The outcomes of this investigation have the potential to serve as a valuable clinical resource for the timely detection of SAE in patients.
Accelerating spiking neural network simulations with PymoNNto and PymoNNtorch
Authors: Vieth Marius , Rahimi Ali , Gorgan Mohammadi Ashena , Triesch Jochen , Ganjtabesh Mohammad
Published: February 2024

Spiking neural network simulations are a central tool in Computational Neuroscience, Artificial Intelligence, and Neuromorphic Engineering research. A broad range of simulators and software frameworks for such simulations exist with different target application areas. Among these, PymoNNto is a recent Python-based toolbox for spiking neural network simulations that emphasizes the embedding of custom code in a modular and flexible way. While PymoNNto already supports GPU implementations, its backend relies on NumPy operations. Here we introduce PymoNNtorch, which is natively implemented with PyTorch while retaining PymoNNto's modular design. Furthermore, we demonstrate how changes to the implementations of common network operations in combination with PymoNNtorch's native GPU support can offer speed-up over conventional simulators like NEST, ANNarchy, and Brian 2 in certain situations. Overall, we show how PymoNNto's modular and flexible design in combination with PymoNNtorch's GPU acceleration and optimized indexing operations facilitate research and development of spiking neural networks in the Python programming language.
Updating perspectives on spinal cord function: motor coordination, timing, relational processing, and memory below the brain
Authors: Grau James W. , Hudson Kelsey E. , Johnston David T. , Partipilo Sienna R.
Published: February 2024

Those studying neural systems within the brain have historically assumed that lower-level processes in the spinal cord act in a mechanical manner, to relay afferent signals and execute motor commands. From this view, abstracting temporal and environmental relations is the province of the brain. Here we review work conducted over the last 50 years that challenges this perspective, demonstrating that mechanisms within the spinal cord can organize coordinated behavior (stepping), induce a lasting change in how pain (nociceptive) signals are processed, abstract stimulus–stimulus (Pavlovian) and response-outcome (instrumental) relations, and infer whether stimuli occur in a random or regular manner. The mechanisms that underlie these processes depend upon signal pathways (e.g., NMDA receptor mediated plasticity) analogous to those implicated in brain-dependent learning and memory. New data show that spinal cord injury (SCI) can enable plasticity within the spinal cord by reducing the inhibitory effect of GABA. It is suggested that the signals relayed to the brain may contain information about environmental relations and that spinal cord systems can coordinate action in response to descending signals from the brain. We further suggest that the study of stimulus processing, learning, memory, and cognitive-like processing in the spinal cord can inform our views of brain function, providing an attractive model system. Most importantly, the work has revealed new avenues of treatment for those that have suffered a SCI.
Connecting atrial fibrillation to digestive neoplasms: exploring mediation via ischemic stroke and heart failure in Mendelian randomization studies
Authors: Xu Zhijie , Rao Xuezhi , Xing Yaxuan , Zhu Zhiwei , Yan Longmei , Huang Jian , Zhang Jingchun , Zheng Ruwen
Published: February 2024

Background

Notwithstanding the acknowledged interplay between atrial fibrillation (AF) and the emergence of digestive system neoplasms, the intricacies of this relationship remain ambiguous. By capitalizing univariable Mendelian Randomization (MR) complemented by a mediated MR tactic, our pursuit was to elucidate the causative roles of AF in precipitating digestive system malignancies and potential intermediary pathways.

Method

This research endeavor seeks to scrutinize the causal clinical implications of whether genetic predispositions to AF correlate with an increased risk of digestive system malignancies, employing MR analytical techniques. Utilizing a dataset amalgamated from six studies related to AF, encompassing over 1,000,000 subjects, we performed univariable MR assessments, employing the random-effects inverse-variance weighted (IVW) methodology as our principal analytical paradigm. Subsequently, a mediated MR framework was employed to probe the potential mediating influence of AF on the nexus between hypertension (HT), heart failure (HF), ischemic stroke (IS), coronary artery disease (CAD), and digestive system neoplasms.

Result

The univariable MR evaluation unveiled a notable causal nexus between the genetic inclination toward AF and the genetic susceptibility to colon, esophageal, and small intestine malignancies. The mediated MR scrutiny ascertained that the genetic inclination for AF amplifies the risk profile for colon cancer via IS pathways and partially explains the susceptibility to esophageal and small intestine tumors through the HF pathway.

Conclusion

Our investigative endeavor has highlighted a definitive causative association between genetic inclination to AF and specific digestive system neoplasms, spotlighting IS and HF as instrumental mediators. Such revelations furnish pivotal perspectives on the complex genetic interconnections between cardiovascular anomalies and certain digestive tract tumors, emphasizing prospective therapeutic and diagnostic worthy of pursuit.
Air traffic inefficiencies and predictability evaluation using route mapping—the Tokyo International Airport case
Authors: Andreeva-Mori Adriana
Published: February 2024

Air traffic inefficiencies lead to excess fuel burn, emissions and air traffic controller (ATCo) workload. Various stakeholders have developed metrics to assess the operation performance. Most metrics compare the actual trajectories to some benchmark ones to calculate excess time or distance. This research is inspired by cellular automata (CA) and develops a combined time-distance lateral inefficiency and predictability metric using discrete space and time mapping on published flight routes. The analysis is focused on Tokyo International Airport, but uses only track data and published routes, which makes it easily applicable to any other hub airport worldwide. The mapping and velocity analyses are used to investigate when and where ATCos are most likely to intervene to provide save separation. A metric which can be adjusted to evaluate both traffic flow predictability and efficiency is proposed. This metric can be applied to better understand current traffic and enable future improvements towards seamless air traffic flow management.
Clinical application of endoscopic diaphragmotomy and dilation in a congenital duodenal diaphragm
Authors: Sun Song , Zheng Shan , Wu Jie , Tang Zifei , Shen Chun , Chen Gong , Dong Kuiran
Published: February 2024

Background

A congenital duodenal diaphragm (CDD) is a rare cause of duodenal obstruction in infants and children. The traditional approach to treatment has been surgical intervention either with excision and duodenoplasty or with bypass through a duodenoduodenostomy, which is invasive and carries the risk of anastomotic leakage.

Aims

To summarize the key points of differential diagnosis and treatment of a CDD under gastroscopy and to evaluate its efficacy and safety.

Methods

The clinical data of patients with a duodenal obstruction diagnosed and treated by gastroscopy in our hospital between January 2019 and December 2022 were retrospectively analyzed. The gastroscopic features of the CDD were summarized. The clinical outcomes of patients with CDD treated by gastroscopy were collected and investigated.

Results

A total of 13 children with a duodenal obstruction underwent a gastroscopic examination and/or treatment, and of these, 10 were diagnosed as having a CDD and 3 were finally diagnosed as having an annular pancreas. A dome-shaped structure during inspiration (9/10) and a guidewire that could be inserted through the opening into the distal lumen (6/10) were the gastroscopic features of the CDD, while the annular pancreas had none of these features. The 10 patients, 4 men and 6 women with the CDD, were treated through endoscopic diaphragmotomy and dilation. The age and weight at operation was 15 days to 7 years (M: 2.25 years) and 2.85–22 kg (M: 13.6 kg), respectively. A total of 11 endoscopic operations were performed in the 10 patients. The time of single operation was 15–55 min (M: 38 min). The patients did not experience complications such as bleeding, pneumoperitoneum, and duodenal papilla injury during the operation. Feeding was started 12–24 h after surgery, and the patients were discharged 2–10 days (M: 7 days) postoperatively. The patients were followed up for 3–36 months (M: 17 months), and none of them had a recurrence of vomiting. However, three showed a recurrence of stenosis in upper gastrointestinal imaging, one of whom underwent a partial diaphragm resection again 2 months after the primary treatment.

Conclusions

A CDD can be confirmed by endoscopy based on its characteristic features. Endoscopic diaphragmotomy and balloon dilation are safe and effective, which can be a new option for minimally invasive treatment of a CDD.
Body morphology and handgrip strength parameters of the female canoe slalom paddlers
Authors: Busta Jan , Hellebrand Jaroslav , Kinkorová Ivana , Duchoňová Andrea , Hybská Tereza , Sánchez Carmen Costa , Vajda Matej
Published: February 2024

Introduction: Canoe slalom is a physically very demanding discipline, in which body constitution, body composition, and relative strength are significant factors in high performance. Although anthropometric and strength parameters are relatively well-studied in male athletes, there is a lack of evidence for any conclusions in women. Therefore, the objective of this study was to determine the morphology and upper-limb strength parameters of female canoe slalom paddlers and identify whether morphological differences exist between performance groups.

Methods: Altogether, 63 female competitors of the 2023 ICF Canoe Slalom World Cup (n = 29) and 2023 ICF Canoe Slalom World Ranking Competition (n = 34) in Prague (Czech Republic) were examined with a battery of anthropometric tests, segmental bioimpedance analysis, and handgrip strength test. The athletes were divided into groups according to age and performance: elite athletes belonging to the world top 10 according to the ICF World Ranking (WORLD, n = 7), international-level athletes competing during the World Cup (ELITE, n = 22), international-level junior athletes competing in the World Ranking Race (JUNIOR, n = 17), and other lower performance-level athletes competing in the World Ranking Race (REST, n = 17).

Results: Female slalom paddlers are, in general, of average body height (∼165 cm), lower body mass (∼60 kg), BMI (∼22 kg/m2), and body fat (∼20%) and without exceptional anthropometric dimensions and proportions. However, differences were detected when performance was factored in. Female paddlers belonging to the world TOP 10 have the largest circumferences of arms and forearms, and their somatotype is more mesomorphic, with a lower proportion of total body fat and a higher proportion of muscle mass. In addition, the WORLD group differs significantly in upper-limb strength.

Discussion: The results shows the significance of muscular strength and power for canoe slalom athletes and the importance of well-developed musculature in operating the boat in the unstable environment. Being a successful female canoe slalom athlete requires a well-developed musculature, maximizing strength capabilities while maintaining a low body weight through limited hypertrophy of the lower limbs and a low level of body fat.
The effects of prolonged pacifier use on language development in infants and toddlers
Authors: Kanellopoulos Alexandros K. , Costello Sarah E.
Published: February 2024

Pacifiers are a common soothing tool used by parents to calm and comfort infants and toddlers. While pacifiers can provide temporary relief, there is growing concern about the potential long-term effects of prolonged pacifier use on language and cognitive development. Previous studies have suggested that prolonged use of pacifiers may have negative consequences on language outcomes in infants and toddlers, especially during the first few years of life known to be a critical period for language development. Previous studies have shown that children who use pacifiers extensively have smaller vocabulary sizes at 1 and 2 years of age which can have subsequent effects on socioemotional. In addition, significant association between greater frequency of daytime pacifier use and worsening of cognitive outcomes was shown. Furthermore, research has shown a strong dose–response association between intense pacifier use up to 4 years of age and lower IQ at 6 years. Recently, the importance of oral motor movements and sensorimotor production for speech perception in infants as young as 6 months has been highlighted, raising important questions on the effect of oral motor movement restrictions at an early age. Together, these findings raise concern about the potential long-term effects of prolonged pacifier use on language and cognitive development at a critical time in child development. However, it is still debatable within the scientific field the potential relationship between pacifier use and language development in early life most likely due to the complexity of studying child development. This mini review aims to provide valuable insights for parents, caregivers, and healthcare professionals in making informed decisions and understand regarding pacifier use for infants and toddlers.
Case report: Adult with bipolar disorder and autism treated with ketamine assisted psychotherapy
Authors: Harris Christopher P. , Jones Becky , Walker Kathryn , Berry Meredith S.
Published: February 2024

Background

Evidence has increased in recent years regarding the potential for ketamine to serve as a novel treatment option for a range of conditions, particularly depression (unipolar and bipolar). However, research regarding ketamine as a potential therapeutic for Autism Spectrum Disorder (ASD) is lacking, despite high overlap with bipolar depression and theoretical foundations for its use.

Case presentation

A 29-year-old man with bipolar disorder and Autism Spectrum Disorder, type 2 diabetes, presented with mood swings and suicidal thoughts, and anger outbursts occurring daily. The patient was referred by a psychiatrist due to irritability and outbursts during the previous 5 months. These outbursts were unable to be controlled by the medications prescribed, included yelling and screaming, and the patient was unable to speak with the psychiatrist. The patient underwent ketamine assisted psychotherapy with 6 initial IV infusions of ketamine over a 1 month period followed by 2 booster IV ketamine infusions. Following ketamine treatment, dramatic reductions in outbursts were observed as well as reductions in anxiety, suicidality, and depression scores.

Conclusion

This case study adds to the scant literature regarding ketamine treatment for individuals with bipolar disorder and ASD. We did not find ASD to be a contraindication for IV ketamine and ketamine assisted psychotherapy. Reductions in anger outbursts, anxiety, suicidality, and depression suggest ketamine treatment might be tailored to individuals with bipolar disorder and ASD, and additional systematized research is warranted. Although potential mechanisms of action are not clear, these data add to the discussion regarding clinical practice considerations and the potential for ketamine to improve quality of life and associated metrics.
A streamlined multidisciplinary metabolic clinic in psychiatric recovery service: a pilot study
Authors: Leung Kelvin CY. , Bakr Bianca , Chung Cindy , Parmar Mayuri , Elhindi James , Brakoulias Vlasios
Published: February 2024

Background

The metabolic syndrome (MetS) is a collection of risk factors for cardiovascular disease and type-2 diabetes, that includes central obesity, hypertension, hyperglycaemia and dyslipidaemia. An audit indicated inadequate MetS screening in an Australian psychiatric recovery service.

Objectives

We aimed to improve MetS screening, identification and intervention by offering streamlined lifestyle education, clinical reviews and discharge planning. This pilot program prioritized holistic, culturally-sensitive, patient-centric, and trauma-informed approaches to enhance metabolic health outcomes.

Methods

A Metabolic Clinic was piloted in two psychiatric rehabilitation cottages (n=35), which involved disciplines of dietetics, exercise physiology, diversional therapy, occupational therapy, peer workforce, social work, clinical psychology, pharmacy, nursing and medical. Another cottage (n=15) was assigned as the comparison and received standard care. A 12-week, 3-times-per-week lifestyle and behavioral program, called MetFit, was devised and offered to those identified at screening for the treatment cottages. Outcome measures were feasibility measures, the five metabolic parameters (waist circumference, blood pressure, fasting serum triglycerides, high-density lipoprotein, and glucose), functional measures, and a meal questionnaire.

Results

The treatment cottages had qualitative advantages in screening and identifying MetS. Of four enrolled consumers in MetFit, an improvement of triglycerides (p=0.08), squats (p=0.02), and push-ups (p=0.07) was observed. Major challenges of enrolment included an overall lack of acknowledgment of its importance, poor motivation of consumers and resources limitation.

Conclusions

The one-stop provision of groups, peer support and inpatient pathway with multidisciplinary team-integration was generally accepted by consumers and the MDT and has iteratively demonstrated the urgent need for consumer-centered physical care and a cultural shift to foster collaboration within a psychiatric service.
Examining the dynamic and nonlinear impacts of public health events on the resilience of food supply chain: evidence from China
Authors: Li Jingdong , Li Zhi , Shi Zilong , Geng Hongjun
Published: February 2024

Introduction

The fragility of agriculture makes the food supply chain vulnerable to external risks such as epidemic, conflict, disaster, climate change, economic and energy crisis. The COVID-19 pandemic has spread and continued globally in recent years, resulting in food supply chain disruption and insecurity, which triggers profound reflection on the impacts of public health events (PHEs). Studying the impacts of PHEs on the resilience of food supply chain has great significance to effectively reduce the risks of disruption and insecurity in the future.

Methods

Based on the composition of PHEs and the division of food supply chain, this paper adopted the nonlinear Granger causality test to verify the nonlinear causal relationship between PHEs and proxy variables in the food supply chain; then the TVP-VAR-SV model was constructed and its three-dimensional pulse response results were matched with the sensitivity, recovery, and adaptation of the food supply chain resilience to deeply explore the dynamic impacts of PHEs.

Results

PHEs has significant nonlinear conduction effects on the resilience of food supply chain, the impacts of PHEs on the partial sector resilience have significant dynamic characteristics in the whole sample period, and the impacts of PHEs on the recovery and adaptation aspects of food supply chain resilience have structural break characteristics.

Discussion

The differences, dynamic characteristics and structural breaks of the impacts of PHEs on the resilience of food supply chain are caused by the infectivity and mortality of PHEs, attributes of food products, regulation of supply and demand in the market, behavioral decisions of all participants, changes in the policy environment, and coordination and upgrading of all sectors in the supply chain.
A PRISMA-IPD systematic review and meta-analysis: does age and follow-up improve active range of motion of the wrist and forearm following pediatric upper extremity cerebral palsy surgery?
Authors: Song Amy X. , Saad Anthony , Hutnik Lauren , Chandra Onrina , McGrath Aleksandra , Chu Alice
Published: February 2024

Purpose

Surgical treatments such as tendon transfers and muscle lengthening play a significant role in cerebral palsy management,but timing of upper extremity cerebral palsy surgery remains controversial. This study systematically reviews the current literature and investigates the correlation between age at surgery and follow-up time with surgical outcomes in pediatric upper extremity cerebral palsy patients.

Methods

A comprehensive search of PubMed, Cochrane, Web of Science, and CINAHL databases was performed from inception to July 2020 and articles were screened using PRISMA guidelines to include full-text, English papers. Data analysis was performed using itemized data points for age at surgery, follow-up length, and surgery outcomes, reported as changes in active forearm and wrist motion. A 3D linear model was performed, to analyze the relationship between age, follow-up length, and surgery outcomes.

Results

A total of 3,855 papers were identified using the search terms and a total of 8 studies with itemized patient data (n=126) were included in the study. The studies overall possessed moderate bias according to the ROBINS-I scale. Regression analysis showed that age is a significant predictor of change (|t| > 2) in active forearm supination (Estimate = −2.3465, Std. Error = 1.0938, t-value= −2.145) and wrist flexion (Estimate = −2.8474, Std. Error = 1.0771, t-value = −2.643) post-intervention, with older individuals showing lesser improvements. The duration of follow-up is a significant predictor of improvement in forearm supination (Estimate = 0.3664, Std. Error = 0.1797, t-value = 2.039) and wrist extension (Estimate = 0.7747, Std. Error = 0.2750, t-value = 2.817). In contrast, forearm pronation (Estimate = −0.23756, Std. Error = 0.09648, t-value = −2.462) and wrist flexion (Estimate = −0.4243, Std. Error=0.1859, t-value = −2.282) have a significant negative association with follow-up time.

Conclusion

These results suggest that there is significant correlation between the age and follow up after surgery with range of motion gains. Most notably, increased age at surgery had a significant negative correlation with select active range of motion postoperative outcomes. Future research should focus on identifying other factors that could affect results of surgical treatment in upper extremity.
Prevalence of pre-iridal monocellular and fibrovascular membranes in canine globes affected with congenital glaucoma associated with anterior segment dysgenesis, primary glaucoma associated with goniodysgenesis, and secondary glaucoma
Authors: Bedos Leila , Sandmeyer Lynne , Campbell John , Grahn Bruce H.
Published: February 2024

Objectives

The objectives of this study were to (i) evaluate the prevalence of pre-iridal monocellular and fibrovascular membranes in canine globes affected with congenital glaucoma associated with anterior segment dysgenesis (ASD), primary glaucoma associated with goniodysgenesis (GD), and secondary glaucoma, and (ii) examine the associations between monocellular and fibrovascular membranes by breed, gender, age and histopathologic ocular changes on light microscopic examination.

Methods

Records of dogs who had eyes enucleated due to blindness and uncontrolled glaucoma were reviewed. Glaucoma was categorized clinically and histologically into three groups: congenital/ASD, primary/GD, and secondary glaucoma. The presence or absence and type of pre-iridal membrane (monocellular or fibrovascular) and other intraocular histologic findings were reviewed and compared statistically for each group.

Results

In total, 108 canine globes (101 dogs) were included. Pre-iridal monocellular membranes were identified with light microscopy in 10 out of 19 congenital/ASD, 29 out of 40 primary, and 23 out of 49 secondary glaucoma globes. Fibrovascular membranes were observed in 3 out of 19 congenital/ASD, 9 out of 40 in primary, and 24 out of 49 secondary glaucoma globes. There were no associations between the type of membrane and breed, gender, or age. Peripheral anterior synechiae were more common in globes with fibrovascular membranes, and uveal atrophy was more common in globes with monocellular membranes.

Conclusion

Pre-iridal monocellular membranes are common in all types of canine glaucoma. They are identified with light microscopy most easily in cases of primary glaucoma, and they are masked by pre-iridal fibrovascular membranes in other forms of glaucoma.
Sri Dewi
Authors: Sri Dewi Santika , Hidayanti Desi
Published: February 2024

Asuhan komprehensif merupakan asuhan yang diberikan secara menyeluruh dan berkesinambungan selama kehamilan, persalinan, bayi baru lahir, nifas, dan keluarga berencana. Selama kehamilan seorang ibu dapat mengalami ketidaknyamanan seperti sakit pinggang, punggung dan kecemasan menghadapi persalinan. Bidan dapat memfasilitasi ketidaknyamanan tersebut dengan menerapkan asuhan komplementer salah satunya adalah prenatal yoga. Penelitian menunjukan bahwa prenatal yoga memiliki dampak positif baik secara fisik ataupun psikologis selama kehamilan dalam menghadapi proses persalinan. Laporan kasus ini bertujuan untuk mendeskripsikan penerapan prenatal yoga dalam asuhan kebidanan komprehensif. Laporan ini menggunakan metode studi kasus yang dilakukan penulis secara komprehensif kepada Ny.H yang diberikan asuhan sejak usia kehamilan 37 minggu sampai dengan nifas beserta asuhan pada bayinya. Asuhan dilaksanakan di wilayah kerja Puskesmas Gadog Kabupaten Garut. 

Asuhan diberikan sesuai dengan diagnosa dan permasalahan yang dialami klien,  dimulai pada kehamilan trimester III sampai dengan minggu terakhir masa nifas. Keluhan yang dialami dalam kehamilan trimester III dapat teratasi dengan prenatal yoga. Proses persalinan ibu berlangsung normal dan terdapat laserasi perineum derajat dua. Asuhan pada bayi baru lahir dalam batas normal. Asuhan kebidanan komprehensif dengan penerapan prenatal yoga sudah dilakukan dengan baik. Bidan sebagai provider kesehatan dapat memfasilitasi prenatal yoga pada ibu hamil untuk mengatasi ketidaknyamanan trimester III
ASUHAN KEBIDANAN KOMPREHENSIF PADA NY. N DENGAN PENERAPAN PIJAT OKSITOSIN DIWILAYAH KERJA PUSKESMAS SELAAWI KABUPATEN GARUT 2023
Authors: Samosir Meliana , Wardani Sri Wisnu
Published: February 2024

Latar Belakang: Asuhan kebidanan komprehensif dimulai dari masa kehamilan, persalinan, nifas dan bayi baru lahir. Pada masa nifas dapat ditemukan masalah laktasi, salah satu penyebab ketidaklancaran pengeluaran ASI dapat ditimbulkan oleh kurangnya rangsangan hormon oksitosin dan prolactin yang sangat berperan pada kelancaran produksi ASI. Memperlancar ASI, dapat diterapkan dengan melakukan pijat oksitosin. Tujuan tugas akhir ini untuk menerapkan asuhan kebidanan dengan penerapan pijat oksitosin secara komprehensif sesuai dengan standar pelayanan dan kewenangan kebidanan serta wewenang bidan. Metode: Laporan ini menggunakan jenis studi kasus yang dilakukan secara komprehensif pada Ny. N selama masa kehamilan, persalianan, nifas, dan  bayi baru lahir di Puskesmas Selaawi Kabupaten Garut pada bulan Februari-Maret 2023. Hasil: Hasil asuhan kebidanan komprehensif yang dilakukan pada Ny. N sejak kehamilan, persalinan, nifas, hingga bayi baru lahir yang diberikan sudah sesuai dengan manajemen bidan standar kebidanan. Selama masa kehamilan trimester III, ibu mengalami ketidaknyamanan yaitu nyeri pinggang. Setelah diberikan konseling body mekanik cara duduk, berdiri, berbaring dan cara mengambil barang yang benar, ibu merasakan keluhannya berkurang. Terdapat masalah dan kesenjangan antara teori dan praktik yaitu  pemberian antibiotic pada ibu dengan luka perieneum derajat dua serta mengalami ASI tidak keluar dan pada bayi diberikan susu formula pada hari pertama kelahiran bayi. Simpulan:  Konseling pemberian ASI dilakukan saat masa kehamilan sehingga persiapan menyusui lebih matang.
EFFECT OF AGRONOMIC AMENDMENTS ON GROWTH AND YIELD OF SUNFLOWER
Authors: Raj Deepak , Kandhro Muhammad Nawaz , Buriro Mahmooda , Jamro Ghulam Murtaza , Channa Siraj Ahmed
Published: February 2024

Proper planting geometry helps in obtaining optimum plant population and crop yield; while irrigation at right time results in improved higher crop yields and quality of the produce. Two years field experiments were conducted during (2019 and 2020) at Tandojam to examined the effect of sowing methods (Raised bed, Ridge, Drilling and Broadcasting); planting densities (Recommended, high density and ultra-high density) and nutrient management (90+60+60+0, 90+60+60+10 and 90+60+ 60+20 kg ha-1 NPK+FeSO4). The experimental design was randomized complete block design with three replicates. The best result in all parameters on  average factors including drilling method, high density planting (66,666 plants ha-1), NPK+FeSO4: 90+60+60+20 kg ha-1 and their interaction resulted in economically superior overall sunflower performance in relation to its growth, seed yield and quality attributes. The drilling method was highly effective to improve seed yield apart from the lower biological yield due to greater harvest index as compared to rest of the sowing methods. Although, recommended plant spacing (55,555 plants ha-1) produced better individual plant based results, but due to lesser plant population, the overall seed yield was greater under high density planting (66,666 plants ha-1).Ultra high density plantation (83,333 plants ha-1) did not prove beneficial due to crowded plant population where harvest index became poor but biological yield increased. Higher FeSO4 improved the grain quality and no effect on foliage; hence 20 kg FeSO4 remained economically most beneficial to achieve desired seed production.
Acceptabilité sociétale de la vaccination des animaux domestiques
Authors: Dufour Barbara
Published: February 2024

L’acceptabilité sociétale de la vaccination des animaux est discutée dans cet article qui présente d’abord les objectifs des différentes catégories de parties prenantes de cette vaccination : les propriétaires d’animaux de compagnie dont l’approche est de type individuelle et essentiellement affective et ceux d’animaux de production dont les objectifs également individuels sont plutôt d’ordre épidémiologique et économique, les particuliers (consommateurs) n’ayant pas d’objectifs particuliers pour la vaccination des animaux, et enfin l’État, qui a des objectifs collectifs soit d’ordre économique soit d’ordre sanitaire (santé publique pour les zoonoses). Les déterminants de l’acceptabilité de la vaccination par ces différents acteurs sont ensuite analysés à la lumière de ces objectifs. Mots-clés : vaccination, acceptabilité sociétale
SARS COV-2 Infection in an Allergic Asthma Patient Taking Omalizumab: A Case Report
Authors: Dikici Ümmügülsüm , Özdemir Öner
Published: February 2024

In March 2020, the World Health Organization declared a pandemic due to the coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus affecting the respiratory tract. Comorbid diseases with severe lung involvement were defined for this infection. Due to its multifactorial pathophysiology, asthma has become one of the most curious, researched, and controversial diseases with comorbidity. The relationship between viral load and disease symptoms of biological agents, which are becoming more important and increasingly used in treating chronic diseases, is being investigated. Omalizumab is a human anti-immunoglobulin E (IgE) antibody approved for asthma and chronic urticaria use. We present the course of COVID-19 disease in a 20-year-old patient with allergic asthma whose asthma symptoms were under control with omalizumab for one year. Our patient had an outpatient course for COVID-19 without developing a cough or other asthma attack symptoms and without hospitalization. By presenting this case, we would like to emphasize that omalizumab treatment during COVID-19 disease does not affect the course of the disease.
The analysis of the 2018-2022 Aceh provincial government financial Reports using a ratio analysis approach (viewpoints in the special autonomy framework)
Authors: Gustyari Wahyu , Sinaga Leonard Rizal , Muda Iskandar
Published: February 2024

The aim of this research is to analyze the ratios of the Aceh provincial government's financial reports. Financial ratio analysis is useful for determining the financial health of local governments both now and in the future. The ratios used are the effectiveness ratio, efficiency ratio, growth ratio, independence ratio, compatibility ratio, liquidity ratio and solvency ratio. This research uses secondary data taken from the website, namely taking the 2018-2022 Aceh provincial government financial report. The results show that the independence ratio is very low, the effectiveness ratio is very good, the efficiency ratio is good, the growth ratio is still fluctuating, the compatibility ratio can be said to be good, the liquidity ratio is very good, the solvency ratio less than good.
Polícia Militar do Paraná e o policiamento baseado em evidências: avanços, desafios e resultados
Authors: De Deus Maria Fernanda de Carvalho , Zancan Carolina Pauleto Ferraz
Published: February 2024

A pesquisa científica apresentada tem a finalidade de apresentar as ações preventivas da Polícia Militar do Paraná (PMPR) no combate à criminalidade. Na metodologia utilizou-se o enfoque qualitativo e como tipo de estudo o descritivo, sendo elaborada uma pesquisa bibliográfica, tendo sido elaborada com base em material já publicado. Inicialmente, aborda a evolução histórica da Segurança Pública, destacando seu papel fundamental na sociedade contemporânea. O embasamento legal é discutido, ressaltando a responsabilidade do Estado e o papel das Polícias Militares, conforme a Constituição Federal. O estudo examina a atuação da PMPR ao longo dos anos, com ênfase em programas preventivos. Explora-se também o conceito de policiamento baseado em evidências para então chegar-se à Companhia Operacional de Recobrimento Preventivo (CORP), como uma iniciativa recente, enfocando atividades preventivas e indicando resultados promissores. Conclui-se, ressaltando que o estudo não representa um encerramento, mas um ponto de partida para análises mais aprofundadas e discussões contínuas, reconhecendo a necessidade de uma abordagem em constante evolução diante das complexidades da segurança pública.
СОЗДАНИЕ И СОСТАВЛЕНИЕ УЧЕБНИКОВ, УЧЕБНЫХ ПОСОБИЙ, ПРОГРАММ, ИСПОЛЬЗУЕМЫХ ПРИ ОБУЧЕНИИ КЫРГЫЗСКОМУ ЯЗЫКУ ДЛЯ ПРОФЕССИЙ СТУДЕНТОВ, ОБУЧАЮЩИХСЯ АВИАЦИОННЫМ СПЕЦИАЛЬНОСТЯМ.
Authors:   Авиационный институт им. И. Абдраимова, Абдырахманова А.
Published: February 2024

This topic is devoted to the creation and compilation of textbooks, teaching aids and programs used in teaching the Kyrgyz language to aviation students. The development of the Kyrgyz language in the aviation sector is an important aspect, since it is the state language of the Kyrgyz Republic and reflects the cultural heritage of the country. In this regard, the development of a special approach to teaching the Kyrgyz language to aviation students will significantly improve their communication skills and promote effective interaction in the professional field. Aviation textbooks, manuals and programs should take into account the specifics of aviation terminology, the peculiarities of grammar and phonetics of the Kyrgyz language, and also provide students with practical exercises to develop writing, reading, speaking and listening skills. On their basis, students will be able to effectively apply the learned language structures and expressions within the framework of their professional activities. As a result, the creation of high-quality textbooks, teaching aids and programs will contribute to the successful teaching of the Kyrgyz language to aviation students and to improving their professional level.
Effect of substrate temperature on structural, morphological, and optical properties of Gallium Oxide thin films deposited by RF-Sputtering
Authors: Yıldız Fevkani , Akçay Hülya , Astam Aykut , Kundakçı Mutlu
Published: February 2024

In this paper, gallium oxide (Ga2O3) thin films at various substrate temperatures (Ts) were grown on Indium Tin Oxide (ITO), glass, p-type silicon by radio-frequency magnetron sputtering (RFMS). We investigated how structural, morphological and optical properties change with various Ts. XRD results of thin films grown on p-type silicon substrate suggest that crystallinity properties of synthesized thin films strongly depend on the Ts. From SEM and AFM analyses of Ga2O3 thin films grown on p-type silicon substrate, it was observed that when the temperature increased, a porous structure appeared, and the grain size changed depending on the Ts. Moreover, obtained results from the absorption measurements, the bandgap energy of Ga2O3 thin films grown on the p-type silicon substrate decreased with increasing substrate temperature.
Investigation of the Phase Mechanism Behaviors of Fe-Cr-Ni alloy by Molecular Dynamics Simulation
Authors: Duman Merve , Çelik Fatih Ahmet
Published: February 2024

In the presented study, Fe-Cr-Ni ternary alloy system, which is classified as medium entropy alloys, was modelled using molecular dynamics (MD) simulation method. Model system was built at specific concentration ratios in accordance with the crystal lattice structures in the phase diagrams. The potential energy function based on the Grujicic-Zhou (GZ) type embedded atom method (EAM) was chosen as the potential function suitable for the system. The phase transformation mechanisms of the model system were investigated by applying heating-cooling processes on the most stable structures. In these processes, thermodynamic parameters such as temperature, volume, potential energy and density were calculated. In addition, the phase transformation mechanism and structural properties were analysed using radial distribution functions (RDF). Three-dimensional pictures of MD cells and the number of crystal structures were obtained using the visualization and analysis software via the atomic positions obtained during the transformations. In all these processes, the results obtained by the MD calculation method were interpreted and compared with the experimental data.
A Broadband Suspended Plate Antenna with Dual Polarization for 2G/3G/Wi-Fi/4G/LTE
Authors: Miran Emre Alp , Uzman Burak , Okan Tayfun
Published: February 2024

Design of a broadband, dual-polarized suspended patch antenna covering 2G/3G/Wi-Fi/4G bands (1710-2690 MHz) is presented. The prototype consists of two suspended plates and a feedline layer. Excitation of ±45 slant dual polarization is realized by a novel crossed elliptic-H slot. The prototype exhibits 48.7% impedance bandwidth (|S11|, |S22| < −15 dB) in 1660-2730 MHz. Port isolation (|S21|) is obtained as > 28 dB. In desired operating band, stable and symmetric radiation patterns with half-power beamwidths of 55-75 and 65-74 in E and H planes are measured, respectively. Gain variation lies within 8.3±0.8 dBi. Proposed antenna is low profile, has high port isolation and high front to back ratio without needing any secondary reflector ground plane. With these qualifications and performance specifications, it outperforms many of the similar works in the literature. Design considerations, simulations and measurement results of proposed antenna are presented and discussed.
ÖĞRETMEN VE ÖĞRENCİ GÖZÜNDEN SINIFLARDA ÜST DÜZEY DÜŞÜNME BECERİLERİNİN KAZANDIRILMASI VE BELİRLENMESİ
Authors: Coşkun Çağatay , Gelbal Selahattin
Published: February 2024

Günümüzde öğrencilerden, yalnızca belirli bir alana özgü bilgileri edinmeleri beklenmemekte bunun yanı sıra bilişsel, duyuşsal ve sosyal beceriler kazanmaları ve bu becerilerini yaşamlarında kullanmaları beklenmektedir. Bu nedenle öğretim etkinliklerinin ve ölçme-değerlendirmelerinin bu becerileri geliştirecek şekilde uyumlu olması gerekmektedir. Bu çalışmada üst düzey düşünme becerileri olarak tanımlanan becerilerin kazandırılması ve belirlenmesine yönelik yapılan sınıf içi uygulamalara ilişkin görüşlerin incelenmesi amaçlanmaktadır. Çalışma kesitsel tarama araştırması olarak yürütülmüştür. Çalışmaya amaçsal tabakalı örnekleme yöntemi ile belirlenen 275 ortaokul branş öğretmeni, ölçüt örnekleme yöntemi kullanılarak belirlenen 243 8.sınıf öğrencisi katılmıştır. Öğretmenlere Öğretmenlerin Düşünme Becerilerinin Öğretimine Yönelik Sınıf İçi Uygulamalar Ölçeği ve anket formu uygulanmıştır. Ayrıca 8. sınıf öğrencileri için düşünme becerilerinin gelişiminde işe koşulan öğretim etkinliklerinin belirlenmesi amacıyla geliştirilen Düşünme Dostu Sınıf Ölçeği kullanılmıştır. Çalışmanın bulgularına göre öğretmenler, öğrencilerin katılımını destekleyecek uygulamalar yaptıklarını belirtirken, iş birliği gerektiren grup çalışması uygulamalarına daha az yer verdiklerini ifade etmişlerdir. Öğrenciler de benzer şekilde grup çalışmalarına daha az katıldıkları yönünde görüş bildirmişlerdir. Üst düzey düşünme becerilerinin belirlenmesi için ise öğretmenlerin çoktan seçmeli maddeler içeren Milli Eğitim Bakanlığının yayımladığı örnek çalışma sorularına benzer sorulardan oluşan testleri daha fazla kullandıkları sonucuna ulaşılmıştır. Buradan hareketle düşünme becerilerinin kazandırılmasına katkı sağlayacak şekilde sınıf içi ölçmeleri öğretim ile yakınlaştıracak uygulamalar tartışılmıştır.