bluuebunny/crossref_metadata_2025 huggingface dataset:
Parental Attachment and Problematic Internet Use among Chinese Adolescents: The Moderating Role of Gender and Grit
Authors: Lan Xiaoyu , Wang Wenchao
Published: December 2020

Problematic Internet use (PIU) is currently becoming a more serious public health concern, representing a deleterious effect on adolescent adaptive emotional and behavioral patterns. Given the prevalence of PIU and its deleterious impact on adolescents’ optimal functioning, it is valuable to investigate the risk and protective factors of PIU. Guided by a socio-ecological framework, the current study examines the associations of paternal attachment and maternal attachment with PIU among Chinese adolescents. Furthermore, this study investigates whether adolescents’ gender and grit moderate this association. A total of 2677 Chinese adolescents (56.5% girls; Mage = 15.56; SD = 1.57) was involved in this study. Adolescents were uniformly instructed to complete a battery of self-reported questionnaires. The results of linear regression analyses showed that paternal attachment and maternal attachment security were negatively related to PIU. Moreover, moderation analyses revealed that higher levels of grit buffered against boys’ PIU in the context of paternal attachment security and girls’ PIU in the context of paternal attachment insecurity. The current study suggests that parental attachment security plays an important role in mitigating the likelihood of Chinese adolescents’ PIU. Moreover, the buffering role of grit in PIU varies by the levels of paternal attachment security, depending on the adolescents’ gender.
COVID-19 Down Under: Australia’s Initial Pandemic Experience
Authors: Cook Matthew James , Dri Gabriela Guizzo , Logan Prishanee , Tan Jia Bin , Flahault Antoine
Published: December 2020

The following case study aims to provide a broad overview of the initial Australian epidemiological situation of the novel coronavirus disease (COVID-19) pandemic. We provide a case presentation of Australia’s current demographic characteristics and an overview of their health care system. The data we present on Australia’s COVID-19 situation pertain to the initial wave of the pandemic from January through to 20 April 2020. The results of our study indicate the number of reported COVID-19 cases in Australia reduced, and Australia initially managed to successfully flatten the curve—from an initial doubling time of 3.4 days at the end of March 2020 to a doubling time of 112 days as of 20 April 2020. Using SEIR mathematical modelling, we investigate a scenario assuming infections increase once mitigation measures are lifted. In this case, Australia could experience over 15,000 confirmed cases by the end of April 2020. How Australia’s government, health authorities and citizens adjust to preventative measures to reduce the risk of transmission as well as the risk of overburdening Australia’s health care system is crucial. Our study presents the initial non-pharmaceutical intervention measures undertaken by the Australian health authorities in efforts to mitigate the rate of infection, and their observed and predicted outcomes. Finally, we conclude our study by presenting the observed and expected economic, social, and political disruptions Australians may endure as a result of the initial phase of the pandemic.
The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme Q10 Status and Mitochondrial Function
Authors: Proctor Emma C. , Turton Nadia , Boan Elle Jo , Bennett Emily , Philips Suzannah , Heaton Robert A. , Hargreaves Iain P.
Published: December 2020

Methylmalonic acidemia is an inborn metabolic disease of propionate catabolism, biochemically characterized by accumulation of methylmalonic acid (MMA) to millimolar concentrations in tissues and body fluids. However, MMA’s role in the pathophysiology of the disorder and its status as a “toxic intermediate” is unclear, despite evidence for its ability to compromise antioxidant defenses and induce mitochondrial dysfunction. Coenzyme Q10 (CoQ10) is a prominent electron carrier in the mitochondrial respiratory chain (MRC) and a lipid-soluble antioxidant which has been reported to be deficient in patient-derived fibroblasts and renal tissue from an animal model of the disease. However, at present, it is uncertain which factors are responsible for inducing this CoQ10 deficiency or the effect of this deficit in CoQ10 status on mitochondrial function. Therefore, in this study, we investigated the potential of MMA, the principal metabolite that accumulates in methylmalonic acidemia, to induce a cellular CoQ10 deficiency. In view of the severe neurological presentation of patients with this condition, human neuroblastoma SH-SY5Y cells were used as a neuronal cell model for this investigation. Following treatment with pathological concentrations of MMA (>0.5 mM), we found a significant (p = 0.0087) ~75% reduction in neuronal cell CoQ10 status together with a significant (p = 0.0099) decrease in MRC complex II–III activity at higher concentrations (>2 mM). The deficits in neuronal CoQ10 status and MRC complex II–III activity were associated with a loss of cell viability. However, no significant impairment of mitochondrial membrane potential (ΔΨm) was detectable. These findings indicate the potential of pathological concentrations of MMA to induce a neuronal cell CoQ10 deficiency with an associated loss of MRC complex II–III activity. However, in the absence of an impairment of ΔΨm, the contribution this potential deficit in cellular CoQ10 status makes towards the disease pathophysiology methylmalonic acidemia has yet to be fully elucidated.
Special Issue—“Diseases of the Salivary Glands”
Authors: Sisto Margherita
Published: December 2020

Salivary glands (SGs) are of the utmost importance for maintaining the health of the oral cavity and carrying out physiological functions such as mastication, protection of teeth, perception of food taste, and speech [...]
Extra-Gastric Manifestations of Helicobacter pylori Infection
Authors: Gravina Antonietta G. , Priadko Kateryna , Ciamarra Paola , Granata Lucia , Facchiano Angela , Miranda Agnese , Dallio Marcello , Federico Alessandro , Romano Marco
Published: December 2020

Helicobacter Pylori (H. pylori) is a Gram-negative flagellated microorganism that has been extensively studied since its first isolation due to its widespread diffusion and association with numerous diseases. While the bacterium is proved to be a causative factor for a number of gastric diseases such as gastritis, gastric adenocarcinoma, and MALT-lymphoma, its role at other gastrointestinal levels and in other systems is being thoroughly studied. In this article, we reviewed the latest published clinical and laboratory studies that investigated associations of H. pylori with hematologic diseases such as Vitamin B12- and iron-deficiency anemia, primary immune thrombocytopenia, and with a number of dermatologic and ophthalmic diseases. In addition, the putative role of the bacterium in inflammatory bowel diseases, esophageal disorders, metabolic, diseases, neurologic diseases and allergy were outlined.
Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis
Authors: Bienvenu Francois-Henri , Tiffet Théophile , Maucort-Boulch Delphine , Gerfaud-Valentin Mathieu , Kodjikian Laurent , Perard Laurent , Burillon Carole , Durel Cécile-Audrey , Hot Arnaud , Jamilloux Yvan , Seve Pascal
Published: December 2020

Background: Sarcoidosis is one of the leading causes of uveitis. To date, no studies have assessed the factors specifically related with recovery in ocular sarcoidosis. In this study, we aimed to determine factors associated with ocular and extraocular recovery in patients with sarcoid uveitis. Methods: A retrospective study of sarcoid uveitis, with a three-year minimum follow-up in Lyon University Hospital between December 2003 and December 2019. Patients presented biopsy-proven sarcoidosis or presumed sarcoid. Recovery was defined by a disease-free status, spontaneously or despite being off all treatments for three years or more. Results: 143 patients were included: 110 with biopsy-proven and 33 with presumed sarcoid uveitis. Seventy-one percent were women, the median age at presentation was 53 years, and 71% were Caucasian. Chronic uveitis was the main clinical presentation (75%), mostly panuveitis (48%) with bilateral involvement (82%). After a median follow-up of 83.5 months, recovery was reported in 26% of patients. In multivariable analysis, Caucasian ethnicity (p = 0.007) and anterior uveitis (p = 0.008) were significantly associated with recovery, while increased intraocular pressure was negatively associated (p = 0.039). Conclusion: In this large European cohort, one quarter of patients recovered. Caucasian ethnicity and anterior uveitis are associated with ocular and extraocular recovery.
Hardness, an Important Indicator of Bone Quality, and the Role of Collagen in Bone Hardness
Authors: Ibrahim Ahmed , Magliulo Nicole , Groben James , Padilla Ashley , Akbik Firas , Abdel Hamid Z.
Published: December 2020

Bone is a nanocomposite material where the hard inorganic (hydroxyapatite crystallites) and organic (collagen fibrils) components are hierarchically arranged in the nanometer scale. Bone quality is dependent on the spatial distributions in the shape, size and composition of bone constituents (mineral, collagen and water). Bone hardness is an important property of bone, which includes both elastic and plastic deformation. In this study, a microhardness test was performed on a deer bone samples. The deer tibia shaft (diaphysis) was divided into several cross-sections of equal thickness; samples were prepared in untreated, boiled water treatment (100 °C for 30 min) and sodium hypochlorite (NaOCl) treatment conditions. Microhardness tests were performed on various regions of the tibial diaphysis to study the heterogeneous characteristics of bone microhardness and highlight the role of the organic matrix in bone hardness. The results indicated that boiled water treatment has a strong negative correlation with bone hardness. The untreated bone was significantly (+20%) harder than the boiled-water-treated bone. In general, the hardness values near the periosteal surface was significantly (23 to 45%) higher than the ones near the endosteal surface. Samples treated with NaOCl showed a significant reduction in hardness.
Variable Correlation between Bronchoalveolar Lavage Fluid Fungal Load and Serum-(1,3)-β-d-Glucan in Patients with Pneumocystosis—A Multicenter ECMM Excellence Center Study
Authors: Mercier Toine , Aissaoui Nesrine , Gits-Muselli Maud , Hamane Samia , Prattes Juergen , Kessler Harald H. , Mareković Ivana , Pleško Sanja , Steinmann Jörg , Scharmann Ulrike , Maertens Johan , Lagrou Katrien , Denis Blandine , Bretagne Stéphane , Alanio Alexandre
Published: December 2020

Pneumocystis jirovecii pneumonia is a difficult invasive infection to diagnose. Apart from microscopy of respiratory specimens, two diagnostic tests are increasingly used including real-time quantitative PCR (qPCR) of respiratory specimens, mainly in bronchoalveolar lavage fluids (BAL), and serum β-1,3-d-glucan (BDG). It is still unclear how these two biomarkers can be used and interpreted in various patient populations. Here we analyzed retrospectively and multicentrically the correlation between BAL qPCR and serum BDG in various patient population, including mainly non-HIV patients. It appeared that a good correlation can be obtained in HIV patients and solid organ transplant recipients but no correlation can be observed in patients with hematologic malignancies, solid cancer, and systemic diseases. This observation reinforces recent data suggesting that BDG is not the best marker of PCP in non-HIV patients, with potential false positives due to other IFI or bacterial infections and false-negatives due to low fungal load and low BDG release.
Bimetallic AgPd/UiO-66 Hybrid Catalysts for Propylene Glycol Oxidation into Lactic Acid
Authors: Ten Sergey , Torbina Viktoriia V. , Zaikovskii Vladimir I. , Kulinich Sergei A. , Vodyankina Olga
Published: December 2020

Different methods (the wetness impregnation of Ag and Pd precursors dissolved in water or acetonitrile solution, and the double solvent impregnation technique) were employed to immobilize Ag–Pd nanoparticles (NPs) into the pores of the microporous zirconium-based metal-organic framework known as UiO-66. The obtained materials were characterized by using nitrogen adsorption-desorption at −196 °C, powder X-ray diffraction, UV-Vis diffusion reflectance spectroscopy, and transition electron microscopy measurements. Special attention was paid to the acid and redox properties of the obtained materials, which were studied by using temperature-programmed desorption of ammonia (TPD-NH3) and temperature-programmed reduction (TPR-H2) methods. The use of a drying procedure prior to reduction was found to result in metallic NPs which, most likely, formed on the external surface and were larger than corresponding voids of the metal-organic framework. The formation of Ag–Pd alloy or monometallic Ag and Pd depended on the nature of both metal precursors and the impregnation solvent used. Catalytic activity of the AgPd/UiO-66 materials in propylene glycol oxidation was found to be a result of synergistic interaction between the components in AgPd alloyed NPs immobilized in the pore space and on the external surface of UiO-66. The key factor for consistent transformation of propylene glycol into lactic acid was the proximity between redox and acid-base species.
Effect of Different Irrigation Solutions on the Diffusion of MTA Cement into the Root Canal Dentin
Authors: Martinho José Pedro , França Sara , Paulo Siri , Paula Anabela Baptista , Coelho Ana Sofia , Abrantes Ana Margarida , Caramelo Francisco , Carrilho Eunice , Marto Carlos Miguel , Botelho Maria Filomena , Girão Henrique , Marques-Ferreira Manuel
Published: December 2020

(1) Aim: This study aims to analyze the in vitro infiltration of a silicate root canal sealer into dentinal tubules after using different endodontic irrigating solutions. (2) Methods: Twenty-nine teeth with single roots were separated into three groups according to the final irrigation protocol: G1 n = 10) = 17% EDTA (ethylenediaminetetraacetic acid) + 3.0% sodium hypochlorite (NaOCl), G2 (n = 10) = 17% EDTA + 2.0% chlorhexidine and G3 (Control group, n = 9) = 17% EDTA + saline solution. Root canals were filled using cold lateral compaction technique with MTA Fillapex sealer and gutta-percha. The sealer was labeled with rhodamine B. The teeth were segmented at the middle and third apical sections, which were visualized using 10× confocal laser microscopy to determine the sealer penetration percentage. (3) Results: In the apical section, no statistically significant differences were found between the groups regarding sealer penetration. In the middle section, Group 1 obtained the highest percentage, and Group 2 the lowest (p = 0.004). Group 1 also presented statistically significant differences in the Control Group (p = 0.031) and had close sealer penetration values. Meanwhile, the Control Group (p = 0.023) and Group 2 (p = 0.029) revealed a significant decrease of sealer penetration between the apical and middle sections. (4) Conclusion: The obtained results support that final irrigation with NaOCl promoted similar sealer penetration in the apical and middle sections. On the other hand, a significant decrease in the sealer penetration of the middle section was observed for the chlorhexidine and saline groups. Compared to other irrigant solutions, NaOCl promotes more uniform sealer penetration, which can correlate with better sealing and, consequently, higher endodontic treatment success.
Quasi-Analytical Model of the Transient Behavior Pressure in an Oil Reservoir Made Up of Three Porous Media Considering the Fractional Time Derivative
Authors: Alcántara-López Fernando , Fuentes Carlos , Brambila-Paz Fernando , López-Estrada Jesús
Published: December 2020

The present work proposes a new model to capture high heterogeneity of single phase flow in naturally fractured vuggy reservoirs. The model considers a three porous media reservoir; namely, fractured system, vugular system and matrix; the case of an infinite reservoir is considered in a full-penetrating wellbore. Furthermore, the model relaxes classic hypotheses considering that matrix permeability has a significant impact on the pressure deficit from the wellbore, reaching the triple permeability and triple porosity model wich allows the wellbore to be fed by all the porous media and not exclusively by the fractured system; where it is considered a pseudostable interporous flow. In addition, it is considered the anomalous flow phenomenon from the pressure of each independent porous medium and as a whole, through the temporal fractional derivative of Caputo type; the resulting phenomenon is studied for orders in the fractional derivatives in (0, 2), known as superdiffusive and subdiffusive phenomena. Synthetic results highlight the effect of anomalous flows throughout the entire transient behavior considering a significant permeability in the matrix and it is contrasted with the effect of an almost negligible matrix permeability. The model is solved analytically in the Laplace space, incorporating the Tartaglia–Cardano equations.
Preparation of a Hybrid Membrane from Whey Protein Fibrils and Activated Carbon to Remove Mercury and Chromium from Water
Authors: Ramírez-Rodríguez Laura Cristina , Díaz Barrera Luis Eduardo , Quintanilla-Carvajal María Ximena , Mendoza-Castillo Didilia Ileana , Bonilla-Petriciolet Adrián , Jiménez-Junca Carlos
Published: December 2020

Water contamination by mercury and chromium has a direct effect in human health. A promising technology to remove heavy metals by membrane filtration is the use of hybrid membranes produced with whey protein fibrils (WPF) and activated carbon (AC). In this study, the best conditions to produce WPF by heat treatment were determined to maximize the removal of mercury and chromium from water using a central composed design. The results indicated that the best conditions to prepare WPF were 74 °C, 7 h and 3.8% of whey protein with adsorption capacities of 25 and 18 mg/g and removal efficiencies of 81 and 57% for mercury and chromium, respectively. WPF and AC were used to prepare a hybrid membrane that was characterized using transmission electron microscopy, atomic force microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy and Brunauer–Emmett–Teller surface area measurements. Batch filtration experiments were performed with the hybrid membrane for chromium and mercury removal at 25, 50 and 100 mg/L to determine its adsorption capacities. A high performance of the hybrid membrane was demonstrated removing efficiently mercury and chromium from water, thus supporting more than ten filtration cycles.
Harmonic Structure Design: A Strategy for Outstanding Mechanical Properties in Structural Materials
Authors: Sharma Bhupendra , Dirras Guy , Ameyama Kei
Published: December 2020

Structured heterogeneous materials are ubiquitous in a biological system and are now adopted in structural engineering to achieve tailor-made properties in metallic materials. The present paper is an overview of the unique network type heterogeneous structure called Harmonic Structure (HS) consisting of a continuous three-dimensional network of strong ultrafine-grained (shell) skeleton filled with islands of soft coarse-grained (core) zones. The HS microstructure is realized by the strategic processing method involving severe plastic deformation (SPD) of micron-sized metallic powder particles and their subsequent sintering. The microstructure and properties of HS-designed materials can be controlled by altering a fraction of core and shell zones by controlling mechanical milling and sintering conditions depending on the inherent characteristics of a material. The HS-designed metallic materials exhibit an exceptional combination of high strength and ductility, resulting from optimized hierarchical features in the microstructure matrix. The experimental and numerical results demonstrate that the continuous network of gradient structure in addition to the large degree of microstructural heterogeneity leads to obvious mechanical incompatibility and strain partitioning, during plastic deformation. Therefore, in contrast to the conventional homogeneous (homo) structured materials, synergy effects, such as synergy strengthening, can be obtained in HS-designed materials. This review highlights recent developments in HS-structured materials as well as identifies further challenges and opportunities.
Serum Metabolite Biomarkers for Predicting Residual Feed Intake (RFI) of Young Angus Bulls
Authors: Foroutan Aidin , Fitzsimmons Carolyn , Mandal Rupasri , Berjanskii Mark V. , Wishart David S.
Published: December 2020

Residual feed intake (RFI) is a feed efficiency measure commonly used in the livestock industry to identify animals that efficiently/inefficiently convert feed into meat or body mass. Selection for low-residual feed intake (LRFI), or feed efficient animals, is gaining popularity among beef producers due to the fact that LRFI cattle eat less and produce less methane per unit weight gain. RFI is a difficult and time-consuming measure to perform, and therefore a simple blood test that could distinguish high-RFI (HRFI) from LRFI animals (early on) would potentially benefit beef farmers in terms of optimizing production or selecting which animals to cull or breed. Using three different metabolomics platforms (nuclear magnetic resonance (NMR) spectrometry, liquid chromatography-tandem mass spectrometry (LC-MS/MS), and inductively coupled plasma mass spectrometry (ICP-MS)) we successfully identified serum biomarkers for RFI that could potentially be translated to an RFI blood test. One set of predictive RFI biomarkers included formate and leucine (best for NMR), and another set included C4 (butyrylcarnitine) and LysoPC(28:0) (best for LC-MS/MS). These serum biomarkers have high sensitivity and specificity (AUROC > 0.85), for distinguishing HRFI from LRFI animals. These results suggest that serum metabolites could be used to inexpensively predict and categorize bovine RFI values. Further validation using a larger, more diverse cohort of cattle is required to confirm these findings.
Kaolinite-Magnesite or Kaolinite–Talc-Based Ceramics. Part II: Microstructure and the Final Properties Related Sintered Tapes
Authors: Hammas Aghiles , Lecomte-Nana Gisèle , Daou Imane , Tessier-Doyen Nicolas , Peyratout Claire , Zibouche Fatima
Published: December 2020

In recent decades, talc and kaolinite have been widely used as raw materials for the ceramic industry. In this study, the final characteristics of kaolinitic clay mixed with 6 mass% of magnesite obtained in our previous work were compared with those obtained with mixtures of kaolin (kaolin BIP) and talc (as the source of magnesium oxide). However, different amounts of talc in the kaolin powder were studied, namely 10, 30, and 50 mass% of added talc (with respect to kaolin + talc). The tape casting process was used during this work in order to manufacture the green tapes in an aqueous system with 0.2 mass% of dispersant. Subsequently, the green tapes were heated to 1000 and 1100 °C with a dwelling time of 12 min. The green and sintering tapes were characterized using the following techniques: DTA/TG, X-ray diffraction, porosity, and flexural strength analyses. The results obtained from our previous work indicate that the specimen with 6 mass% of MgCO3 sintered at 1200 °C for 3 h exhibited the best performances, with high flexural strength and weak porosity value—117 MPa and 27%—respectively. As results from this study, the optimal mechanical and thermal properties of sintering tapes were obtained for the specimen with 10 mass% of added talc sintered at 1100 °C. Indeed, this specimen exhibited 50 MPa and 43% of stress to rupture and apparent porosity, respectively.
Association of Food and Alcohol Consumption with Peripheral Atherosclerotic Plaque Volume as Measured by 3D-Ultrasound
Authors: Noflatscher Maria , Schreinlechner Michael , Sommer Philip , Deutinger Philipp , Theurl Markus , Kirchmair Rudolf , Bauer Axel , Marschang Peter
Published: December 2020

Background: Food patterns and alcohol consumption influence the risk for cardiovascular diseases (CVD) and a healthy nutrition is essential for the prevention of CVD. The aim of this study was to determine the influence of nutrition and alcohol consumption on peripheral atherosclerotic plaque volume (PV) using an innovative 3D ultrasound approach. Methods: In this prospective, single centre study we included 342 patients with at least one cardiovascular risk factor or established CVD. PV in the carotid and femoral artery was measured using a semi-automatic software. Information on food and alcohol consumption of the participants was collected using an internationally acknowledged standardized questionnaire (DEGS1). Results: Patients with low total PV consumed significantly more vegetables (p = 0.004) and vegetable juice (p = 0.019) per week compared to patients with high total PV. In contrast, patients with high total PV reported a higher alcohol consumption compared to patients with low total PV (p = 0.026). Patients without vascular disease, in particular cerebrovascular disease (p = 0.001) and peripheral arterial disease (p = 0.012), reported a significantly higher fish consumption per week. In the multivariate model, we found a significant negative association for vegetable consumption (p = 0.034) and female gender (p = 0.018) but a significant positive association for alcohol (p = 0.001), age (p < 0.001) the presence of vascular disease (p < 0.001) and cardiovascular risk factors (p < 0.001) with total PV. Conclusion: In this study we were able to show an association of food and alcohol consumption with peripheral atherosclerotic PV measured by 3D-ultrasonography. Following a healthy nutritional lifestyle (vegetable consumption, no excessive alcohol consumption) and regular fish consumption appears to be associated with less peripheral atherosclerosis and decreased prevalence of vascular diseases, respectively.
Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations
Authors: Klyachko Natalia L. , Arzt Camryn J. , Li Samuel M. , Gololobova Olesia A. , Batrakova Elena V.
Published: December 2020

Drug nanoformulations hold remarkable promise for the efficient delivery of therapeutics to a disease site. Unfortunately, artificial nanocarriers, mostly liposomes and polymeric nanoparticles, show limited applications due to the unfavorable pharmacokinetics and rapid clearance from the blood circulation by the reticuloendothelial system (RES). Besides, many of them have high cytotoxicity, low biodegradability, and the inability to cross biological barriers, including the blood brain barrier. Extracellular vesicles (EVs) are novel candidates for drug delivery systems with high bioavailability, exceptional biocompatibility, and low immunogenicity. They provide a means for intercellular communication and the transmission of bioactive compounds to targeted tissues, cells, and organs. These features have made them increasingly attractive as a therapeutic platform in recent years. However, there are many obstacles to designing EV-based therapeutics. In this review, we will outline the main hurdles and limitations for therapeutic and clinical applications of drug loaded EV formulations and describe various attempts to solve these problems.
Facile Fabric Detoxification Treatment Method Using Microwave and Polyethyleneimine Against Nerve Gas Agents
Authors: Kwon Woong , Kim Changkyu , Kim Jiyun , Kim Jongwon , Jeong Euigyung
Published: December 2020

Generally, detoxification fabrics are defined as fabrics that remove or inhibit the production of toxic compounds, especially chemical warfare agents such as nerve gas agents. They are usually prepared using a complicated and time-consuming method. This study suggests a facile treatment method for preparing detoxification fabrics against nerve gas agents using polyethyleneimine and microwave curing. The detoxification properties of polyethyleneimine and microwave-treated polypropylene nonwoven fabric were evaluated using diisopropylfluoro-phosphate, which is a nerve agent simulant. The treated polypropylene fabric decontaminated 53.6% of diisopropylfluorophosphate (DFP) in 2 h at 32 °C, and the half-life of DFP on the surface of the treated fabric was 122 min. The result indicates that the treated fabric can act as a basic organocatalyst for the DFP hydrolysis and has a shorter half-life owing to the large number of amine groups. Therefore, the facile treatment method has the potential for use in the preparation of detoxification fabrics.
Well Defined Poly(Methyl Methacrylate)-Fe3O4/Poly(Vinyl Pivalate) Core–Shell Superparamagnetic Nanoparticles: Design and Evaluation of In Vitro Cytotoxicity Activity Against Cancer Cells
Authors: Resende Graciane , Dutra Gabriel V. S. , Neta Maria S. B. , Araújo Olacir A. , Chaves Sacha B. , Machado Fabricio
Published: December 2020

The objective of this work is to develop and characterize polymeric nanoparticles with core–shell morphology through miniemulsion polymerization combined with seeded emulsion polymerization, aiming at the application in the treatment of vascular tumors via intravascular embolization. The synthesis of the core–shell nanocomposites was divided into two main steps: (i) Formation of the core structure, consisting of poly(methyl methacrylate)/magnetic oxide coated with oleic acid (OM-OA) via miniemulsion and (ii) shell structure produced through seeded emulsion polymerization of vinyl pivalate. Nanocomposites containing about 8 wt.% of OM-OA showed high colloidal stability, mean diameter of 216.8 nm, spherical morphology, saturation magnetization (Ms) of 4.65 emu·g−1 (57.41 emu·g−1 of Fe3O4), preserved superparamagnetic behavior and glass transition temperature (Tg) of 111.8 °C. TEM micrographs confirmed the obtaining of uniformly dispersed magnetic nanoparticles in the PMMA and that the core–shell structure was obtained by seeded emulsion with Ms of 1.35 emu·g−1 (56.25 emu·g−1 of Fe3O4) and Tg of 114.7 °C. In vitro cytotoxicity assays against murine tumor of melanoma (B16F10) and human Keratinocytes (HaCaT) cell lines were carried out showing that the core–shell magnetic polymeric materials (a core, consisting of poly(methyl methacrylate)/Fe3O4 and, a shell, formed by poly(vinyl pivalate)) presented high cell viabilities for both murine melanoma tumor cell lines, B16F10, and human keratinocyte cells, HaCaT.
Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration
Authors: Ogay Vyacheslav , Mun Ellina A. , Kudaibergen Gulshakhar , Baidarbekov Murat , Kassymbek Kuat , Zharkinbekov Zharylkasyn , Saparov Arman
Published: December 2020

Despite the high regenerative capacity of bone tissue, there are some cases where bone repair is insufficient for a complete functional and structural recovery after damage. Current surgical techniques utilize natural and synthetic bone grafts for bone healing, as well as collagen sponges loaded with drugs. However, there are certain disadvantages associated with these techniques in clinical usage. To improve the therapeutic efficacy of bone tissue regeneration, a number of drug delivery systems based on biodegradable natural and synthetic polymers were developed and examined in in vitro and in vivo studies. Recent studies have demonstrated that biodegradable polymers play a key role in the development of innovative drug delivery systems and tissue engineered constructs, which improve the treatment and regeneration of damaged bone tissue. In this review, we discuss the most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs. In addition, special attention is given to recent developments on polymer nano- and microparticle-based drug delivery systems for bone regeneration.
State of the Art and New Directions on Electrospun Lignin/Cellulose Nanofibers for Supercapacitor Application: A Systematic Literature Review
Authors: Adam Abdullahi Abbas , Ojur Dennis John , Al-Hadeethi Yas , Mkawi E. M. , Abubakar Abdulkadir Bashir , Usman Fahad , Mudassir Hassan Yarima , Wadi I. A. , Sani Mustapha
Published: December 2020

Supercapacitors are energy storage devices with high power density, rapid charge/discharge rate, and excellent cycle stability. Carbon-based supercapacitors are increasingly attracting attention because of their large surface area and high porosity. Carbon-based materials research has been recently centered on biomass-based materials due to the rising need to maintain a sustainable environment. Cellulose and lignin constitute the major components of lignocellulose biomass. Since they are renewable, sustainable, and readily accessible, lignin and cellulose-based supercapacitors are economically viable and environmentally friendly. This review aims to systematically analyze published research findings on electrospun lignin, cellulose, and lignin/cellulose nanofibers for use as supercapacitor electrode materials. A rigorous scientific approach was employed to screen the eligibility of relevant articles to be included in this study. The research questions and the inclusion criteria were clearly defined. The included articles were used to draw up the research framework and develop coherent taxonomy of literature. Taxonomy of research literature generated from the included articles was classified into review papers, electrospun lignin, cellulose, and lignin/cellulose nanofibers for use as supercapacitor electrode materials. Furthermore, challenges, recommendations, and research directions for future studies were equally discussed extensively. Before this study, no review on electrospun lignin/cellulose nanofiber-based supercapacitors has been reported. Thus, this systematic review will provide a reference for other researchers interested in developing biomass-based supercapacitors as an alternative to conventional supercapacitors based on petroleum products.
A One-Year, Multicenter, Retrospective Evaluation of Narrow and Low-Profile Abutments Used to Rehabilitate Complete Edentulous Lower Arches: The OT Bridge Concept
Authors: Montanari Marco , Scrascia Roberto , Cervino Gabriele , Pasi Massimo , Ferrari Emiliano , Xhanari Erta , Koshovari Alba , Tallarico Marco
Published: December 2020

Purpose: To evaluate preliminary data on survival and success rates of immediately loaded, screw-retained, restorations delivered on lower arches using narrow and low-profile OT Equator abutments. Methods: This retrospective study analyzed data of patients rehabilitated with OT Bridge (fixed prosthetic system built on OT Equator) prosthetic concept from November 2017 to February 2019 in five different centers. Outcome measures were implant and prosthetic survival rates, biological and technical complications, marginal bone loss (MBL), oral health impact profile (OHIP), bleeding on probing, and plaque index. Results: A total of 60 implants were inserted in 12 patients. Patients were followed for a mean period of 15.8 months (range 12–24). All the patients received OT Equator as intermediate abutments. Four out of 60 implants were connected to the prosthetic framework using only the Seeger system, without a screw. One year after loading, three implants failed (implant survival rate of 95.0%) in two patients. No prosthesis failed and no major biological and technical complications were experienced. One year after initial loading, the marginal bone level was 0.32 ± 0.2 mm. The OHIP before treatment was 87.7 ± 6.0. One year after treatment, OHIP was 23.6 ± 1.2. The difference was statistically significant (64.1 ± 7.2; p = 0.0000). One year after loading, 8.9% of the examined implant sites present positive bleeding on probing, while 5.8% of the implant sites presented plaque. Conclusions: The OT Equator abutments showed successful results when used to support mandible fixed dental prosthesis delivered on 4–6 implants. Whole prosthetic survival and success rates, high patient satisfaction, and good biological parameters were experienced one year after function. Further prospective studies are needed to confirm these preliminary results.
Recent Advances in Molecularly Imprinted Membranes for Sample Treatment and Separation
Authors: Torres-Cartas Sagrario , Catalá-Icardo Mónica , Meseguer-Lloret Susana , Simó-Alfonso Ernesto F. , Herrero-Martínez José Manuel
Published: December 2020

This review describes the recent advances from the past five years concerning the development and applications of molecularly imprinted membranes (MIMs) in the field of sample treatment and separation processes. After a short introduction, where the importance of these materials is highlighted, a description of key aspects of membrane separation followed by the strategies of preparation of these materials is described. The review continues with several analytical applications of these MIMs for sample preparation as well as for separation purposes covering pharmaceutical, food, and environmental areas. Finally, a discussion focused on possible future directions of these materials in extraction and separation field is also given.
A National Evaluation of State and Territory Roles in Hazard Mitigation: Building Local Capacity to Implement FEMA Hazard Mitigation Assistance Grants
Authors: Smith Gavin , Vila Olivia
Published: December 2020

This article describes the findings of a national survey of State Hazard Mitigation Officers (SHMOs) in U.S. states and territories in order to gain a greater understanding of the roles that they play in assisting local governments to build the capacity required to successfully develop and implement Federal Emergency Management Agency (FEMA)-funded Hazard Mitigation Assistance (HMA) grants, an important but understudied aspect of hazard mitigation governance. The research questions focus on: (1) How states and territories enable local governments to develop and implement HMA grants and (2) SHMOs’ opinions regarding their perceived capacity and effectiveness in assisting local governments to develop and implement HMA grants. Results show that while states and territories are relatively well-equipped to perform general administrative duties required by FEMA, SHMOs expressed wide variation in their capacity to assist local governments to develop and implement HMA grants. This was particularly evident with regard to the delivery of specific technical assistance measures required to develop HMA grants. Survey responses also highlight modest levels of participation in FEMA-designed efforts to delegate responsibility to states and territories and low levels of participation in programs that offer pre-application funding to local governments to help them develop HMA grant applications. These findings should concern FEMA as the agency embarks on the implementation of the Building Resilient Infrastructure and Communities program, an ambitious pre-disaster hazard mitigation grant initiative.
Design Thinking Applied to Smart Home Projects: A User-Centric and Sustainable Perspective
Authors: Martins Flavio , Almeida Maria Fatima , Calili Rodrigo , Oliveira Agatha
Published: December 2020

This paper aims to propose a conceptual model to create and select smart home conceptions from the user-centric and sustainable perspective, using the Design Thinking approach. Although considerable research has been devoted to smart homes in the last two decades, gaps are evident in current research concerning the creation and selection of smart home conceptions from both user-centric and sustainable perspectives. A systematic literature review covering the period 2000–2020 indicated that Design Thinking (DT) has rarely been exploited in smart home projects. The applicability of the proposed model could be demonstrated in the context of a smart home project in Brazil (NO.V.A. Project) conducted by an energy distribution player in this country in cooperation with two local universities and other institutional partners. The replication of this approach in smart home projects will allow decision-makers and project managers to place future residents at the center of the smart home design, creating and selecting the best conceptions that will meet users’ desires, expectations, and needs that can be transformed into reality.
Assessing the Economic Risk of Building Damage due to the Tunneling-Induced Settlement Using Monte Carlo Simulations and BIM
Authors: Providakis Stylianos , Rogers Chris D. F. , Chapman David N.
Published: December 2020

Due to the increasing use of underground space to align with sustainability needs, geohazard risk assessments have become a valuable tool for decision-making. One common issue in relation to urban geohazard assessments relates to ground movements due to tunneling affecting adjacent buildings. A framework for assessing costs related to subsequent building damage, using integrated data, statistics and considering the uncertainties involved, is presented in this paper. The proposed methodology provides an integration of Monte Carlo simulations to support uncertainty estimations with an analysis for building-damage cost risk due to tunneling-induced settlements. The analysis involves analytical models using green-field conditions and a typically used building damage assessment method. BIM is capable of collating, combining and visualizing information with advanced analysis techniques into a risk-based tool. The resulting tool provides a clear way of assessing building-damage costs risk due to tunneling-induced settlements. This uses a BIM-based environment and incorporates 3D visualizations and an integrated analysis via MATLAB to reveal and highlight hazardous areas and the severity of economic risk along the tunneling route. This informs the need for additional ground investigations or secondary analyses to ensure engineering processes reduce or remove the risk of economic damage and advance sustainable decision-making.
Modelling of Health Risk Associated with the Intake of Pesticides from Romanian Fruits and Vegetables
Authors: Minuț Mariana , Roșca Mihaela , Hlihor Raluca-Maria , Cozma Petronela , Gavrilescu Maria
Published: December 2020

This study is focused on the assessment of risks caused by pesticide residues to Romanian and other European populations, by modelling the acute and chronic risks considering short- and long-term exposures to pesticide residues in specific fruits and vegetables from different Romanian regions. Data were obtained from the Romanian 2016 official monitoring programme. For assessing the dietary risk, we used the Pesticide Residue Intake model—PRIMo. According to the official data, it was found that 50.44% of fruit samples and 28.25% of vegetable samples were contaminated with pesticides. Our study focused on acute risks and chronic risks (in a maximalist worst-case scenario) posed by pesticide residues in strawberries, apples, lettuce and potatoes, given both their high degree of consumption and contamination with pesticides. The short-term exposure assessment of children’s health due to consumption of apples, lettuce and potatoes contaminated with dimethoate, chlorothalonil and carbendazim, revealed exposure levels higher than the acute reference dose (ARfD, as 100%), raising acute risks. On the other hand, the long-term exposure assessment showed that the highest percentage from the acceptable daily intake (ADI, as 100%) was obtained for German children (DE child) (273.9%), followed by Netherlands children (NL child) (143.7%) diets, based on consumption of apples with dimethoate residues. Therefore, serious measures are needed for banning pesticides such as dimethoate, chlorothalonil and carbendazim from all countries in the EU. This would reduce the health risks generated by the consumption of contaminated fruits and vegetables.
Numerical Simulation of the Interaction between Fibre Concrete Slab and Subsoil—The Impact of Selected Determining Factors
Authors: Duris Lukas , Hrubesova Eva
Published: December 2020

Shape and material optimization of building structures, including reducing the amount of concrete used, are very important aspects in sustainable construction. Numerical modelling is currently used very effectively to design optimized and sustainable structures, including their interaction with the surrounding rock environment. This paper is focused on the three selected factors of numerical modelling of fibre concrete slab and subsoil interaction: (1) the constitutive model of fibre concrete slab, (2) deformational and strength characteristics of subsoil, (3) effect of interface elements. The specialized geotechnical software Midas GTS NX, based on the finite element method, was used for the modelling of this task. Numerical results were compared with the experimental measurement of vertical displacements on the upper surface of slab. In the presented study, three constitutive models of slab recommended in MIDAS GTS NX code for modelling concrete behaviour (elastic, Mohr-Coulomb and Drucker-Prager) were applied. In addition, the sensitivity analysis with respect to the deformational and strength characteristics of subsoil was performed. The numerical study also presents the effect of the interface elements application on the slab behaviour. The numerical results of maximum vertical displacements based on the Drucker-Prager and elastic model underestimated both the experimental results and numerical results based on the Mohr-Coulomb model. From the qualitative point of view (shape of deflection curve), the numerical simulation showed the better agreement of the Mohr-Coulomb constitutive model with the experimental measurements in comparison with the other two investigated constitutive models. The performed parametric study documented that reduction of the strength and deformational characteristics of subsoil leads to the increase of maximum vertical displacements in the centre of slab, but the experimentally measured deflection curve, including uplift of slab and gapping occurrence between the slab and subsoil, was not achieved without the interface application.
Environmental Impact of Subsidy Concepts for Stimulating Car Sales in Germany
Authors: Scharf Malte , Heide Ludger , Grahle Alexander , Syré Anne Magdalene , Göhlich Dietmar
Published: December 2020

In 2020, vehicle sales decreased dramatically due to the COVID-19 pandemic. Therefore, several voices have demanded a vehicle subsidy similar to the “environmental subsidy” in Germany in 2009. The ecological efficiency of vehicle subsidies is controversially discussed. This paper establishes a prognosis of the long-term environmental impacts of various car subsidy concepts. The CO2 emissions of the German car fleet impacted by the purchase subsidies are determined. A balance model of the CO2 emissions of the whole car life cycle is developed. The implementation of different subsidy scenarios directly affects the forecasted composition of the vehicle population and, therefore, the resulting life-cycle assessment. All scenarios compensate the additional emissions required by the production pull-in within the considered period and, hence, reduce the accumulated CO2 emissions until 2030. In the time period 2019–2030 and for a total number of 0.72 million subsidized vehicles—compensating the decrease due to the COVID-19 pandemic—savings of between 1.31 and 7.56 million t CO2 eq. are generated compared to the scenario without a subsidy. The exclusive funding of battery electric vehicles (BEVs) is most effective, with an ecological break-even in 2025.