bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of miR-3149 on the Malignancy Progression of Gastric Cancer by Negatively Regulating CEACAM5
Authors: Zhao Ruiwen , Zhao Deyao , Zhu Xiaorong , Li Fengying , Xiong Pingping , Li Siting , Liu Junqi
Published: October 2024

Background: There are some reports indicating that carcinoembryonic antigen associated cell adhesion molecule 5 (CEACAM5) can act as a diagnostic indicator or molecular marker for GC, but its upstream regulatory pathway still needs to be explored. microRNAs (miRNAs) regulate gene expression at the translation level and fulfil a crucial role in GC physiologyin, whether miR-3149 in family members can affect GC progression by regulating CEACAM5 is still unclear.
Methods: miR-3149 and CEACAM5 expressions in GC tissues and cells (N87, AGS, and HGC-27) were observed by RT-qPCR or Western blot. Intervened the miR-3149 and CEACAM5 expression in GC cells, CCK8, Wound healing, Transwell and flow cytometry assays evaluated cell activity and function separately, while detecting related proteins. Predicted the target of miR-3149 and the expression of CEACAM5 in tumor tissue through bioinformatics analysis and evaluated the correlation between both using Spearman analysis. Verified the targeting relationship between the two through the Luciferase reporter assay. Conducted another rescue experiment on CEACAM5 overexpression to further verify this relationship.
Results: In GC tissues and cells, miR-3149 and CEACAM5 expression levels were respectively down-regulated and up-regulated. Transfection of miR-3149 mimics or inhibitors respectively reduced or increased GC cell apoptosis and inhibited or encouraged cell proliferation, migration and invasion, which were shown to be enhanced or inhibited respectively by transfection of OE-CEACAM5/Si-CEACAM5, while their apoptosis rate decreased or increased. miR-3149 could target regulating CEACAM5, and showed an inverse correlation with the expression of CEACAM5. The impacts of miR-3149 mimics on the malignancy progression of GC could be partially reversed by OE-CEACAM5.
Conclusion: The results indicate that miR-3149 can downregulate the expression of CEACAM5 to inhibit the malignancy progression, as a GC suppressor,which identify a new miRNA mediated tumor suppressor mechanism in GC.
Recent Advancements in Cancer RNA-interference Therapy with Nanotechnology Strategies
Authors: Abosalha Ahmed Kh. , Islam Paromita , Boyajian Jacqueline L. , Kassab Amal , Makhlouf Stephanie , Santos Madison , Prakash Satya
Published: October 2024

Cancer is a global challenge, and genetics play a major role in onsets and in designing the next generation of cancer therapies. One of the key approaches is the downregulation of genes through RNA interference (RNAi) which has been proposed as a promising tool for controlling cancer-causing genes by employing a complementary base-pairing mechanism. Crucial tools in RNAi; small interfering RNA (siRNA), and microRNA (miRNA) have been extensively utilized in cancer therapy. Despite their discovery nearly two decades ago, only a handful of RNAi-based products have recently gained approval from regulatory authorities like the FDA, principally due to inherent limitations. The efficacy of RNAi therapies is significantly hindered by barriers related to absorption, distribution, metabolism, and excretion, leading to rapid elimination from the systemic circulation before reaching the cytosol of targeted cells. Nevertheless, RNAi therapeutics hold immense promise in various diseases, especially in various types of cancer. Overcoming these challenges demands the design of suitable drug delivery systems and the implementation of strategies aimed at enhancing pharmacokinetic parameters associated with RNAi therapies. Nanotechnology-based vehicles such as polymer-based nanoparticles, lipid nanoparticles, liposomes, dendrimers, and inorganic nanoparticles may serve as efficient carriers for targeting RNAi therapies to their desired sites. This review discusses the recent advances in nanotechnology strategies for RNAi delivery, with the overarching objective of facilitating effective targeting and gene silencing for the advancement of RNAi in cancer therapy.
KESIAPAN SEKOLAH DAN PENOLAKAN TEMAN SEBAYA PADA ANAK USIA DINI
Authors: Rista Erika  , Muhammad Rizal Zaenulloh  , Arif Ahmad Fauzi
Published: October 2024

This article aims to describe the results of research on school readiness and peer rejection in early childhood. School readiness is one of the skills that children must be able to in elementary school. This research was conducted on one child aged 6 years in one private kindergarten. The study was conducted for 6-7 months, using a case study qualitative research method. Data collection is done through observation techniques on children and unstructured interviews with teachers and parents. The results of this study indicate that young children who experience peer rejection are unable to social skills. Meanwhile, social skills are one indicator of school readiness. Based on this research, it is recommended for parents to provide stimulus to children before starting to enter primary school, to teachers to be more intense and optimal in dealing with peer rejection in early childhood, for government policies are expected to provide policies so that elementary and kindergarten parties harmonize perceptions about schools readiness that are not too focused on children's academic abilities.
IMPLEMENTASI METODE BERNYANYI LAGU HURUF VOKAL DAN KONSONAN TERHADAP KEMAMPUAN MEMBACA ANAK USIA 5-6 TAHUN DI PAUD AL-HIDAYAH MANDE
Authors: Lina Marlina  , Muhammad Rizal Zaenulloh  , Arif Ahmad Fauzi
Published: October 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh metode menyanyikan lagu vokal dan konsonan terhadap kemampuan membaca anak usia 5-6 tahun di PAUD Al-Hidayah Mande. Secara khusus, penelitian ini bertujuan untuk mendeskripsikan proses penerapan metode menyanyikan lagu vokal dan konsonan terhadap kemampuan membaca anak usia 5-6 tahun serta tingkat efektivitas metode tersebut terhadap kemampuan membaca anak usia 5-6 tahun di PAUD Al-Hidayah Mande.
Penelitian ini menggabungkan metodologi studi kasus dengan pendekatan kualitatif. Pengumpulan data dilakukan melalui observasi, wawancara mendalam dengan orang tua, pengurus, dan instruktur, serta perekaman proses pendidikan di PAUD Al-Hidayah Mande membawakan lagu yang mengandung vokal dan konsonan.
Hasil penelitian menunjukkan bahwa teknik menyanyikan lagu vokal dan konsonan dapat meningkatkan tingkat pemahaman bacaan anak usia lima hingga enam tahun. Pembelajaran dengan pendekatan ini meningkatkan kemampuan anak-anak untuk mengenali dan mengucapkan huruf, mengingat vokal dan konsonan, merangkai huruf menjadi suku kata, dan merangkai suku kata menjadi kata. Jelas dari uraian sebelumnya bahwa menyanyikan lagu vokal dan konsonan merupakan cara yang sangat efisien untuk membantu anak-anak meningkatkan kemampuan membaca mereka.
Judicial Review Peninjauan Kembali Yang Dilakukan Oleh Badan Atau Pejabat Tata Usaha Negara
Authors: Fajar Rachmad Dwi Miarsa  , Hardi Anugrah Santoso  , M. Zamroni  , Wahyu Ariadi
Published: October 2024

Penelitian Penelitian ini bertujuan untuk memberikan wawasan terkait adanya putusan Mahkamah Konstitusi mengenai Peninjauan kembali upaya hukum oleh Badan atau Pejabat Tata Usaha Negara yang sudah tidak diperbolehkan lagi setelah dikeluarkan putusan tersebut. Meskipun pada Undang-undang sebelumnya pengajuan PK telah menjadi kewenangan PTUN yang tertera dalam UU Peratun No. 5 tahun 1986. Metodologi penulisan yang dipakai berbentuk yuridis normatif. Metode penelitian adalah disiplin ilmu yang mempelajari langkah-langkah dalam proses penelitian, atau ilmu yang terkait dengan metode ilmiah yang digunakan untuk mengambil, membeberkan, dan mengevaluasi keakuratan informasi. Dalam penelitian ini dilakukan pendekatan undang-undang (statute approach) dan pendekatan analitis (analitycal approach). Upaya hukum adalah suatu jalan hukum yang diberikan kepada seseorang atau badan hukum oleh undang-undang, yang merasa belum mendapat keadilan dari putusan hakim di pengadilan. Upaya hukum yang demikian ada dua bentuknya, yaitu upaya hukum biasa terdiri dari dua jenis upaya hukum: Banding, Kasasi. Upaya hukum Luar Biasa: Peninjauan Kembali. Arti demikian ini tentunya tidak terkecuali bagi siapapun dapat mengajukan upaya hukum ke pengadilan, asal sesuai dengan ketentuan dan tidak berlawanan dengan undang-undang yang berlaku. Sama halnya dengan Badan atau Pejabat Tata Usaha Negara yang berhak mengajukan upaya hukum berdasarkan dengan undang-undang yang menjadi pedomannya dalam beracara
The Influence of Transformational Leadership Based on Rato Marapu on Organizational Culture Impacts on Teacher Performance in Senior High Schools in Southwest Sumba Regency
Authors: Lede Yohanes Umbu , Nusa Silvester , Sene Mikael , Kelen Konradus Doni , Kami Kanisius
Published: October 2024

Teachers play an important role in realizing quality education, teacher performance is influenced by many factors. The purpose of the study was to investigate and explain the influence of Rato Marapu-based transformational leadership on organizational culture and its impact on teacher performance. The research design was quantitative ex-post facto using a survey approach. The subjects of the study were 726 high school teachers in Southwest Sumba Regency. While the respondents were 297 people determined using the proportional random sampling technique by the Morgan formula then confirmed with Warwick and Lininger. Data collection used a questionnaire with 5-choice closed questions. Data testing applied a structural equation model to the Partial Least Squares approach. The results of the study were; (1) Rato Marapu-based transformational leadership has a strong direct influence on organizational culture based on the T-Statistic test results, namely 3.662 and P-Values, namely 0.000 (2) Rato Marapu-based transformational leadership also has a stronger direct influence on teacher performance based on the T-Statistic test results, namely 4.778 and P-Values, namely 0.000 (3) organizational culture has the strongest direct influence on teacher performance based on the T-Statistic test results, namely 33.864 and P-Values, namely 0.000 (4) Rato Marapu-based transformational leadership also has an indirect influence through organizational culture that has an impact on teacher performance, as evidenced by the T-Statistic test results, namely 3.762 P-Values, namely 0.000. The conclusion is that Rato Marapu-based transformational leadership based on Rato Marapu and organizational culture are predictors that influence teacher performance.
Humanist Ideals in an Era of Increasing Confrontation: The Need to Renew Basic Paradigms
Authors: Vitulyova Yelizaveta , Gabrielyan Oleg , Bakirov Akhat , Suleimenov Ibragim
Published: October 2024

The nature of qualitative transformations of warfare at the present stage is analyzed. It is shown that these transformations will inevitably lead to the question of partial transfer of individual's intelligence to non-biological information carrier. In particular, in the foreseeable future it is predicted that AI will emerge based on the intelligence of officers who possess advisory combat experience. It is shown that tasks of this kind can be solved by existing software tools. It is also shown that the solution of the problem of partial transfer of an individual's consciousness to a non-biological information carrier goes beyond the concept of transhumanism in its existing version. AI built on such a basis, regardless of its intended purpose, becomes a kind of an intermediary between a person and the suprapersonal level of information processing. It is shown that the emergence of such intermediaries can significantly affect social relations, in particular, significantly increase the influence of those philosophical concepts that insist on the importance of collectivism as a factor that is closely related to the humanistic picture of the world. It is shown that, paradoxically, the development of military AI will inevitably serve as one of the factors giving a new impetus to the ideals of humanism.
АНАЛИЗ ФИНАНСОВОГО ПОТЕНЦИАЛА ПАО ПИК СПЕЦИАЛИЗИРОВАННЫЙ ЗАСТРОЙЩИК: ПЕРСПЕКТИВЫ РАЗВИТИЯ КОМПАНИИ
Authors: Томашова В.Д. , Шальнева М.С.
Published: October 2024

Строительная отрасль в настоящее время переживает новый развития. Однако опасения того, что это такая динамика обуславливается стихийным спросом, в таких условиях необходим анализ финансового потенциала компаний сектора. В данной статье рассматриваются перспективы развития компании ПАО ПИК и проводится комплексный анализ ее финансового потенциала. Получение результаты могут быть использованы для более детального изучения динамики развития строительного сектора.

The construction industry is currently experiencing a new development. However, there are fears that such dynamics are caused by spontaneous demand, in such conditions, an analysis of the financial potential of companies in the sector is necessary. This article examines the prospects for the development of PIK PJSC and provides a comprehensive analysis of its financial potential. The results can be used for a more detailed study of the dynamics of the construction sector.
Etično-zgodovinski presek dobrodelnih dejavnosti
Authors:   University of Primorska (Koper/Capodistria, Slovenia), Drobnič Janez
Published: October 2024

The innovativeness of practices in charitable activities can be a driving force for development, but it can also lead to opacity and controversial actions. Therefore, the purpose of this study is to determine the background of charity, especially the ethical and moral foundations throughout its historical development, in order to find better ways into the future. The article provides an overview of the development of charity organizations and explores which ethical elements can be recognized among them. In the first periods of Christian communities, we have identified the selfless and dedicated action of the individual for vulnerable or needy fellow human beings within the framework of the ethics of mercy, while further historical periods recognize the altruistic concept of helping others and striving for community. In the more recent era of individualism and secularism, which offers and practises many innovations, however, it is manifested in a kind of balancing relationship of cooperation between those who help (volunteers) and those who need help.
Interpretación de los jarros rituales de pico (trilobulados) del asentamiento vacceo de Pintia (Valladolid)
Authors: Pérez Gómez Ernesto , Calonge Cano Guillermo
Published: October 2024

Novedosa hipótesis sobre la iconografía que pueden representar la forma y la decoración de ciertos jarros de carácter ritual, hallados en Pintia, a través de la historia.
9 + 1 zonas arqueológicas en Castilla y León. Pintia heterodoxa e irredenta
Authors: Sendino Gallego Roberto
Published: October 2024

Análisis desde distintos puntos de vista de las principales zonas arqueológicas de Castilla y León, teniendo en cuenta el origen de sus presupuestos y el retorno a la sociedad de los mismos.
Campaña XXVIII 2017 de excavaciones arqueológicas en Pintia (Padilla de Duero/Peñafiel)
Authors: Sanz Mínguez Carlos
Published: October 2024

Resumen de los trabajos de campo desarrollados durante la campaña veraniega de 2017. Tras los exiguos resultados de las campañas de 2015 y 2016, en esta ocasión se intervino en cuatro sectores más al oeste; en dos de ellos no se recuperó ninguna tumba, aunque sí un peculiar depósito moderno de basura. Se hallaron sólo cuatro tumbas y un cenotafio, que se traducen en treinta y cuatro objetos. Hay que destacar la tumba 305, cuyo ajuar muestra piezas y decoraciones con un gran contenido simbólico que permiten su datación entre el final del siglo III y el comienzo del II a. C.
Quantitative Evaluation of the Inferential Statistics Integration Skills in Practical Research of Grade 12 Students: As a Basis for a Remediation Program
Authors: Morata Jan Angelo , Poblete John Paolo
Published: October 2024

This study evaluated students' perceived versus actual integration skills in statistics on seven central topics of the course concerning so-called 'inferential statistics,' namely: t-tests (independent and dependent), Analysis of Variance (ANOVA), Chi-square tests, Pearson Product Moment correlation coefficient, Spearman rank correlation coefficient and regression analysis. Descriptive statistics indicated that students perceived their skills as developing (mean = 1.62), but their actual performance was lower, categorized as beginning (mean = 1.38). Students performed weakest on Chi-square tests (mean = 1.10) and ANOVA (mean = 1.30). However, correlation analysis showed that most topics had no significant relationship between perceived performance and actual performance (p = 0.045), except for the Pearson Product Moment correlation coefficient, which had a moderate positive correlation (ρ = 0.260). Despite this, the actual performances for all topics were still low. Thus, the findings show a gap between perceived and actual skills. These results indicate that a comprehensive remediation program will include all seven inferential statistics topics utilized in this study. The course of study in this regard should be designed to enhance conceptual understanding, practical competency, and the student's capacity for appropriate self-assessment. A structured approach that matches focused workshops with practical work and individual support will help ensure that students develop both the theoretical and practical competence they need to do the statistical analysis, and that is through targeted instructional workshops and interactive statistical software training as the remediation program.
DERECHO ADMINISTRATIVO SANCIONADOR Y MINORÍA DE EDAD: HACIA UNA NECESARIA REVISIÓN DEL SISTEMA JURÍDICO-ADMINISTRATIVO ACTUAL
Authors: Sarrato Martínez Luis
Published: October 2024

Juan M.ª Pemán Gavín fue catedrático de Derecho administrativo en la Universidad de Lérida desde octubre de 1990 hasta octubre de 2022, momento en el que obtuvo una cátedra de la indicada disciplina en la Universidad de Zaragoza. Como consecuencia de su buen hacer académico y de su perfil humano, en su permanencia en la universidad ilerdense durante más de tres décadas ha dejado una marcada huella en sus discípulos y colaboradores, de la que pretenden dar testimonio con la presente obra colectiva, conformada por cinco estudios sobre diversos aspectos de derecho administrativo sancionador. Entre los temas abordados se incluyen cuestiones de índole general tales como el principio de oportunidad de la imposición de sanciones, la problemática vinculada a la comisión de infracciones por menores de edad o, en fin, la responsabilidad civil derivada de la infracción. Asimismo, integran el libro dos trabajos de ámbito sectorial, más exactamente sobre el marco sancionador asociado al incumplimiento de la obligación de uso de mascarilla durante la pandemia de covid-19, y acerca del régimen disciplinario de los alumnos articulado por la vigente Ley de Convivencia Universitaria. Todos los trabajos obedecen a un planteamiento metodológico en el que el estudio dogmático de las instituciones y categorías jurídicas, por un lado, y el análisis práctico orientado a identificar aspectos controvertidos y ofrecer respuesta a los mismos, por otro, conviven de manera perfectamente equilibrada.
LA RESPUESTA SANCIONADORA AL INCUMPLIMIENTO DE LA OBLIGACIÓN DE PORTAR MASCARILLA COMO CONSECUENCIA DE LA PANDEMIA
Authors: Oliván del Cacho Javier
Published: October 2024

Juan M.ª Pemán Gavín fue catedrático de Derecho administrativo en la Universidad de Lérida desde octubre de 1990 hasta octubre de 2022, momento en el que obtuvo una cátedra de la indicada disciplina en la Universidad de Zaragoza. Como consecuencia de su buen hacer académico y de su perfil humano, en su permanencia en la universidad ilerdense durante más de tres décadas ha dejado una marcada huella en sus discípulos y colaboradores, de la que pretenden dar testimonio con la presente obra colectiva, conformada por cinco estudios sobre diversos aspectos de derecho administrativo sancionador. Entre los temas abordados se incluyen cuestiones de índole general tales como el principio de oportunidad de la imposición de sanciones, la problemática vinculada a la comisión de infracciones por menores de edad o, en fin, la responsabilidad civil derivada de la infracción. Asimismo, integran el libro dos trabajos de ámbito sectorial, más exactamente sobre el marco sancionador asociado al incumplimiento de la obligación de uso de mascarilla durante la pandemia de covid-19, y acerca del régimen disciplinario de los alumnos articulado por la vigente Ley de Convivencia Universitaria. Todos los trabajos obedecen a un planteamiento metodológico en el que el estudio dogmático de las instituciones y categorías jurídicas, por un lado, y el análisis práctico orientado a identificar aspectos controvertidos y ofrecer respuesta a los mismos, por otro, conviven de manera perfectamente equilibrada.
Libertad ideológica
Authors: Puig Hernández Marc-Abraham
Published: October 2024

La libertad ideológica es un concepto que ha sido asumido de diferente modo en los ordenamientos jurídicos, que exige un esfuerzo argumentativo en su aplicación y, además, puede vincularse a un modo peculiar de desobedecer el ordenamiento, como es el derecho a la objeción de conciencia. Por una parte, este concepto guarda una estrecha relación con las libertades de pensamiento, de conciencia y religiosa. En esta obra se ofrece una propuesta de distinción conceptual que encaja dentro de las coordenadas de nuestro ordenamiento jurídico. Por otra parte, la libertad ideológica no se da en abstracto, al presuponer el ejercicio de un derecho fundamental, sino en contextos delimitados por derechos y obligaciones. Un escenario habitual es el de la discriminación por motivos ideológicos. Resulta necesario acudir a la argumentación jurídica y discutir el peso relativo de este derecho. Para ello, se defiende la necesidad del argumento teleológico, la naturaleza de la relación social y los requisitos que derivan de ella. Finalmente, se lleva a cabo una interpretación orteguiana del ejercicio del pretendido derecho «genérico» a la objeción de conciencia, a diferencia de cualquier otra forma de desobedecer el ordenamiento jurídico.
Impacto del estilo de vida moderno y su relevancia en la salud hepática: etiología y estrategias preventivas
Authors: Mantuano Quiroz María Emilia , Merchán Merchán José Alexander , Chilán Santana Caleb I.
Published: October 2024

El estilo de vida se refiere a los hábitos y conductas que una persona adopta conscientemente a lo largo de su vida, como la alimentación, la actividad física, el sueño y el manejo del estrés. La alta ingesta de alimentos hipercalóricos se ha extendido globalmente. Hoy en día, el hígado graso no alcohólico es la enfermedad hepática crónica más común a nivel mundial. El objetivo general de la presente investigación fue analizar el impacto del estilo de vida moderno y su relevancia en la salud hepática; además de las diferentes estrategias preventivas actuales, utilizando como metodología un diseño de investigación bibliográfico. En los resultados de la investigación se obtuvo que el consumo de alcohol y el tabaquismo se asocian con un incremento en el riesgo de desarrollar cirrosis hepática. Se destacan enfermedades como la hepatitis B y C, donde los principales factores de riesgo incluyen la transmisión sexual, el uso compartido de agujas. Entre las intervenciones destacadas, la educación sobre el uso adecuado de medicamentos se asocia con la prevención de la hepatotoxicidad. Se concluyó que los resultados obtenidos de las tablas presentadas y la literatura revisada subrayan la importancia de un enfoque multifactorial para la prevención y el manejo de las enfermedades hepáticas.
MÉTODOS DE ENSINO E FORMAÇÃO DE PROFESSORES: IMPLEMENTAÇÃO E RESULTADOS
Authors: Souza Luiz Carlos de , Sousa Ingraça Ferreira de , Souza Vilma das Graças Britts de , Lence Fernanda Louzada , Silva Vaneska Maria de Melo , Santos Leidiane Aparecida dos , Araujo Alex Abade Ferreira de , Guimarães Ueudison Alves
Published: October 2024

The teaching and learning process in schools requires robust planning that defines teaching methodologies adapted to the student's reality. In this sense, it is understood that strategic planning establishes a connection between theory and practice, allowing methodologies to be applied and rethought to promote meaningful and dynamic education. The objective of this study is to identify methodologies that can offer new possibilities and positively influence students in an impactful teaching-learning process. To achieve this objective, the research used a theoretical-bibliographical approach. Thus, the types of teaching methodologies used by the analyzed teacher were highlighted, supporting a methodology that is coherent with the students' reality, which intensifies the teaching-learning process, making it tangible, concrete, satisfactory, appropriate and enjoyable. In this way, it becomes clear that the student becomes the protagonist in the construction of his/her own knowledge, while the teacher acts as a mediator of this transformative practice, building an engaging and collaborative teaching-learning environment.
ARQUITETURA BIOMIMÉTICA: COMO A NATUREZA É EXPLORADA NOS PROJETOS ARQUITETÔNICOS
Authors: Silva Amanda França Carvalho , Pedroso Thiago , Santos Philipe do Prado
Published: October 2024

The present work aims to analyze how biomimetic architecture draws inspiration from nature and how this contemporary approach has been applied to architectural projects worldwide. Through an exploratory research study, with bibliographic research procedures and a qualitative approach, the purpose of the investigation was achieved. Based on the information gathered throughout the research, the results obtained include: understanding how biomimetic architecture adapts architectural designs, the strategies and knowledge that transform the concept of architecture and nature, as well as the correlation between nature and biomimetic architecture in the contemporary world. Additionally, an analysis of projects that employed the biomimetic concept was conducted to understand how this methodology is applied in practice.
A QUÍMICA NA COSMETOLOGIA
Authors: Leite Evelyn Cipriano , Iglesias Priscila de Souza
Published: October 2024

O tema principal deste documento é informar a ligação histórica entre a química e a cosmetologia e provar que não existe um sem o outro. Foram feitos estudos sobre as consequências de diversos produtos que já foram empregados na fabricação de maquiagens e seus efeitos sobre as pessoas. Fazendo com que fosse possível analisar como as descobertas químicas impactam o mundo da beleza atualmente, evitando contaminações e o uso de materiais indevidos. E de certa forma perceber como é exacerbada a busca pela beleza na sociedade desde seus primórdios.
Mentes artificiais e o declínio cognitivo da sociedade
Authors: Silva Eduardo
Published: October 2024

Mentes Artificiais e o Declínio Cognitivo da Sociedade explora como o uso excessivo de tecnologia e telas está afetando o comportamento humano e a saúde mental, levando a uma deterioração cognitiva expressiva. A obra reúne pesquisas científicas e observações clínicas para mostrar como a superexposição a dispositivos digitais está comprometendo a capacidade de concentração, reflexão e aprendizado profundo. O livro traz ainda, situações cotidianas que refletem a nossa dependência em dispositivos digitais e também o contexto histórico de como a internet surgiu e chegou neste ponto atual. Além de analisar as consequências desse fenômeno, o livro propõe soluções para reverter os danos, destacando a importância de reequilibrar o uso das telas, especialmente em crianças e adolescentes, e trazendo reflexões sobre o futuro de uma sociedade cada vez mais digitalizada.
الحماية القانونية لحقوق المرأة دولياً ومحلياً
Authors: قشطى نبيلة عبد الفتاح
Published: October 2024

تجلى الاهتمام بحماية حقوق المرأة منذ الإعلان العالمي لحقوق الإنسان وإقراره للحريات الأساسية خاصة مبدأي المساواة وعدم التمييز، وتوالت الاتفاقيات الدولية الخاصة بحماية حقوق المرأة؛ وتمخضت عن إيجابيات لا يمكن إغفالها، من أهمها إصدار الدول كافة على اختلاف مستوياتها العديد من القوانين التي تعنى بحماية حقوق المرأة، وعقد المؤتمرات التي تمنع التمييز ضد المرأة.
وهذه الورقة البحثية تحاول إلقاء الضوء على الواقع الخاص بحماية حقوق المرأة؛ من أجل فهمها بصورة أفضل، والعمل على سد الخلل الموجود بها، وتعديل ما يمكن تعديله وتطويره إن أمكن ذلك.
جريمة التهرب الضريبي في فلسطين
Authors: شحادة ميرفت , عبادي ضرار
Published: October 2024

للضرائب أهمية كبيرة في إيرادات الدولة في فلسطين، خاصة أن إيرادات الدولة متدنية وتعتمد بشكل أساسي على الدعم الخارجي. وتقدم هذه الدراسة تحليلاً لنصوص قانون ضريبة الدخل رقم (8 لسنة 2011)، وصولاً لمعرفة مفهوم جريمة التهرب الضريبي والاثار المترتبة على هذه الجريمة وأركانها وأشكالها، والوقوف على الأسباب الرئيسية للتهرب الضريبي ومعرفة الآليات المتبعه لمكافحة هذه الجريمة.
وفي نهاية هذه الدراسة توصل الباحثان إلى عدة مقترحات، للمساهمة في الحد من هذه الجريمة، تتمثل في تعديل نصوص القانون، بحيث تشتمل على بيان أركان جريمة التهرب الضريبي، وتفعيل آليات الرقابة والضبط من قبل الجهة القضائية المكلفة بتنفيذ أحكام هذا القانون، وتوفير الوعي الضريبي لدى المواطنين.
Estruturas colapsadas
Authors: Silva Rubens Bitan da Costa
Published: October 2024

Este trabalho apresenta um estudo sobre a atual doutrina de emprego da Arma de Engenharia em situação de desastres. O trabalho visa, também, analisar a criação de uma equipe técnica de primeira resposta para eventos dessa natureza, com material já presente na Caixa do Sapador e equipamentos de engenharia.
O Exército Brasileiro na manutenção dos valores da sociedade
Authors: Gomes Guilherme Almeida , Santos Éverton Araújo dos
Published: October 2024

Em meio a crise política, financeira e moral na qual a sociedade brasileira está inserida, o Exército Brasileiro é uma instituição que se mantém resguardada por ter suas missões bem definidas, elevando juntamente as outras duas Forças a instituição de maior confiabilidade. Neste sentido, o presente estudo teve por objetivo buscar as bases dessa crise, principalmente no que tange a falta de valores éticos e morais, para assim descrever a forma como o EB resguarda esse valores tão raros no atual cenário. Foi realizada uma pesquisa bibliográfica baseada em publicações de autores de reconhecida importância no meio acadêmico, em artigos veiculados, bem como reportagens de autoridades. Os resultados indicam que o EB mantém na sua estrutura e até onde a lei permite a preservação dos valores éticos e morais na sociedade.
Impact of Work and Family Conflicts on Productivity and Well-Being during Remote Work
Authors: Goullet David , Sciulli Nathan , Snell Tristan
Published: October 2024

In 2020, most of the Australian workforce engaged in remote work. Border conflicts (work interfering with family conflict and family interfering with work conflict) are negatively associated with well-being and productivity in traditional work settings. The current study aimed to explore the relationship between border conflict, wellbeing, and productivity when working remotely. Method. Participants were 340 adults aged 18 - 62 years (Mean = 33.98, SD = 8.80). To be eligible, individuals needed to be over the age of 18, living in Australia and working from home for at least one hour per week. Respondents reported on their levels of border conflict (Work-Family Conflict scale), wellbeing (Short Warwick-Edinburgh Mental Well-being Scale), productivity (Individual Work Performance Questionnaire) and demographic variables. Hierarchical linear regression analysis assessed associations between border conflict, productivity, and wellbeing. Results. Work interfering with family conflict and family interfering with work conflict demonstrated significant, negative associations with wellbeing Family interfering with work conflict demonstrated a significant, negative association with productivity, but work interfering with family conflict did not. Conclusion. Results demonstrate the importance of considering work and personal in unison when attempting to understanding employee’s productivity and wellbeing, especially when working remotely.
Leader-Member Exchange Quality as Mediator between Toxic Leadership and Organizational Learning in Pakistani Private Banks
Authors: U Zaman Khalique , Faiza Urooj Syeda , Ur Rehman Zia
Published: October 2024

The twenty-first century is shaded with numerous scams that linked to the leadership decisions. Such incidents raise the questions on the ability and intentions of the leadership. It’s been years that leadership is being studies and majority of scholars just focus on the constructive side of the leadership but the darkest and negative traits or behaviours of leaders are not studies. One such behaviour is toxic leadership. The available literature identifies that investigation related to toxic leader and organizational learning with the mediating role of leader-member exchange quality is limited. The study is cross-sectional in nature and convenient sampling technique was employed to collect the data from the individual bankers working in banking sector of Islamabad. A total of 211 responses were used for the study. The descriptive statistics, correlation, linear regression and process macro v4.0 by Andrew F. Hayes were employed for the data analysis. The study findings justify that toxic leadership damages the process of organizational learning and leader-member exchange quality mediates the relationship between toxic leadership and organizational learning. The study further discusses the implications for the banks and practitioners to deal effectively with the toxicity of leaders at different levels.
Role of Effectuation as a Device to Stimulate Innovativeness
Authors: Ahmed Syed Khalid , Hamid Syed Ali Raza
Published: October 2024

This study investigates the mechanisms that link entrepreneurial passion (EP) to product and service innovativeness. The study is causal and cross-sectional research. It investigates the mediating role of effectuation as a mechanism for the relationship between EP and product and service innovativeness. A primary research survey was conducted using a structured questionnaire among 306 respondents of micro small and medium enterprises (MSMEs). The data was analyzed using Hays process analyses SPSS version 4. Findings suggested that effectuation plays a significant role as a mediator to entrepreneurs’ passion for product and service innovativeness in the context of MSMEs in Pakistan. The study finds a strong link between effectuation as a mediator to product and service innovativeness and recommends using the model of effectuation proposed by Sarasvathy (2008) as a process to innovate in the organization. The model of effectuation needs to be understood in order to be applied by new entrepreneurs of MSME. The study suggests academia to develop an understanding of this concept and make it a part of the curriculum of entrepreneurship study for startups and innovations by new entrepreneurs. Effectuation is considered predominantly at theoretical and investigational stages; this study adds the literature by an empirical study of its dynamics in the real-life scenario of established MSME’s. This research recommended the effectuation model to the entrepreneur in order to develop a network for product and service innovativeness instead of trying to do everything on their own.
Factors Influencing the Provision of Quality Education at Somali National University: An Exploratory Study from the Views of the Lecturers
Authors: Hersi Yonis Abdullahi
Published: October 2024

Somali National University was succeeded to reestablish in 2014 after the civil war. This study aimed to explore the adequacy of teaching and learning resources and physical facilities at Somali National University (SNU) and their impact on the provision of quality education. The study involved collecting data from lecturers through a survey, which included questions related to the availability and adequacy of teaching and learning resources and physical facilities. The findings of the study revealed that there are significant gaps in the availability and adequacy of teaching and learning resources at SNU. Lecturers reported inadequate availability of reference books, textbooks, audio-visual equipment, computer labs, and internet facilities. Physical facilities like playgrounds, libraries, and laboratories were also rated as inadequate by the lecturers. These shortcomings have a negative impact on the quality of education provided at SNU. The study recommends that SNU should increase the availability of teaching and learning resources, improve physical facilities, provide accommodations for students with special education needs, provide regular training to lecturers, conduct regular surveys to obtain feedback, increase budgetary allocation, and collaborate with international partners to provide support. Addressing these recommendations will help improve the quality of education at SNU and provide a conducive learning environment for students and lecturers alike.
Perbandingan Analisis Pengendalian Persediaan Barang Consumable Menggunakan Metode Min-Max dan EOQ Pada Supplier General Trading UD. Hasta Jaya
Authors: Achla Tuffachatul , Priyana Efta Dhartikasari , Negoro Yanuar Pandu
Published: October 2024

UD. Hasta Jaya merupakan perusahaan yang bergerak di bidang supplier general trading, memasok berbagai jenis barang consumable diantaranya kain majun dan siku karet plastik. Kurangnya perusahaan dalam memperhatikan arus pengendalian persediaan menjadi masalah utama sehingga bisa mengakibatkan kerugian yang akan dialami oleh Perusahaan secara finansial maupun operasional. Untuk menghitung efisiensi manajemen persediaan yaitu dengan mengetahui komponen, kuantitas pemesanan optimal dalam satu kali pemesanan, serta mengetahui total biaya persediaan dalam menekan biaya menggunakan 2 metode pengendalian persediaan Min-Max dan EOQ. Hasil perhitungan dengan metode EOQ pemesanan dilakukan sebanyak 7 kali, kuantitas pemesanan 949 Kg dan 842 Kg dengan biaya sebesar Rp 930.141 dan Rp 929.704. Sedangkan untuk metode Min-Max yaitu 26 kali pemesanan, dengan kuantitas sebesar 241 Kg dan 122 Kg dan biaya sebesar Rp 1.948.873 dan Rp 3.270.342.
Analisis Persediaan Bahan Kimia Karl Fisher Solvent Pada PT. XYZ dengan Metode Economic Order Quantity (EOQ) dan Periodic Order Quantity (POQ)
Authors: Kurniawan Ridho , Ismiyah Elly
Published: October 2024

PT. XYZ merupakan produsen pupuk terlengkap di Indonesia dimana dalam setiap proses produksinya membutuhkan penjagaan pengawasan kualitas dan penjaminan mutu produk. Dalam hal ini, dibutuhkan laboraorium untuk menganalisis mutu produk hasil produksi. Salah satu bahan pembantu dalam menganalisis mutu produk yaitu bahan kimia cair adalah Karl Fisher Solvent. Penelitian ini dilakukan untuk menghitung dan menganalisis perbandingan jumlah pemesanan, frekuensi pemesanan, safety stok, reorder point, serta total biaya persediaan dengan menggunakan 2 metode pengendalian persediaan EOQ dan POQ, sehingga dapat diketahui metode manakah yang paling optimum, EOQ, POQ, atau perusahaan. Hasil dari analisis didapatkan metode yang paling optimal dalam pengendalian persediaan yaitu metode EOQ dapat menghemat biaya persediaan sebesar 22% dengan kuantitas pemesanan 39 liter, frekuensi pemesanan 4 kali, total biaya persediaan Rp. 284.771, safety stok 4 liter dan reorder point 10 liter.
Klasifikasi Gizi Balita Untuk Deteksi Dini Stunting Menggunakan Metode KNearest Neighbor
Authors: Farhan Naufal Hafiz , Gunawansyah Gunawansyah
Published: October 2024

Status gizi balita adalah indikator penting yang mencerminkan tingkat kesejahteraan masyarakat. Di Indonesia, prevalensi balita dengan gizi buruk dan stunting masih menjadi masalah yang membutuhkan perhatian khusus. Penelitian ini bertujuan untuk mengembangkan sistem klasifikasi status gizi balita dengan menggunakan metode K-Nearest Neighbor (KNN) sebagai alat bantu untuk deteksi dini stunting. Metode KNN dipilih karena kemampuannya dalam mengklasifikasikan data berdasarkan kedekatan jarak. Data yang digunakan dalam penelitian ini berasal dari Puskesmas Cileunyi, dengan parameter antropometri meliputi Usia, Berat Badan, dan Tinggi Badan. Implementasi sistem dilakukan dengan bahasa pemrograman PHP dan basis data MySQL. Hasil pengujian menunjukkan bahwa sistem ini memiliki akurasi sebesar 66,67% untuk klasifikasi Berat Badan menurut Umur (BB/U) dan 100% untuk klasifikasi Tinggi Badan menurut Umur(TB/U). Dengan demikian, sistem ini diharapkan dapat menjadi alat bantu yang efektif bagi tenaga kesehatan dalam melakukan deteksi dini stunting pada balita, sehingga intervensi yang tepat dapat dilakukan lebih awal.
Prescrição de exercícios físicos para a saúde e qualidade de vida em território atingido por barragem
Authors: Souza Nakata Yan , Santos Isadora Ribeiro , Silva Siomara Aparecida da , Assis Aisllan Diego
Published: October 2024

Uma das atividades mobilizadoras da melhoria e obtenção do bem-estar, e principalmente da saúde, é o exercício físico prescrito por um profissional de Educação Física. Nessa perspectiva, foi realizado um programa de extensão com o intuito de proporcionar a prática de exercícios físicos à população de Antônio Pereira. A divulgação através de parcerias com a UBS e o CRAS alcançou um grupo de 16 indivíduos com diversas comorbidades, entre elas: hipertensão, dislipidemia, diabetes, reumatismo e problemas articulares para as práticas de treinamento funcional próximas ao CRAS. Os moradores que aderiram à prática não somente buscaram o benefício motor, mas também a socialização que as atividades físicas proporcionam. Assim, o objetivo deste trabalho é apresentar o processo de construção e realização do projeto de Corrida e caminhada como forma de promoção da saúde e efetivação da Educação Física na saúde coletiva dentro do programa “De Mãos Dadas com Antônio Pereira”. Esperamos a continuidade do programa, buscando alcançar mais pessoas e melhores resultados, com avaliações físicas periódicas, para que assim, seja possível relacionar os benefícios da atividade física com a saúde física e mental das pessoas do território, e a sedimentação da Educação Física na saúde coletiva.
Pura diversão: Jogos e brincadeiras com crianças de Antônio Pereira, Ouro Preto, Minas Gerais
Authors: Neves Correa Karine Marlleny , Santos Ferreira Stephany Leôncio dos , Faria Sandra Andréa , Areda Xavier João Vitor , Mendes Artur Teixeira , Assis Aisllan Diego de
Published: October 2024

O Pura Diversão é um projeto de extensão da Universidade Federal de Ouro Preto que ocorre no distrito histórico de Antônio Pereira, Ouro Preto - MG, que é atingido pela mineração. O projeto atende as crianças da faixa etária de 03 a 15 anos, traz a ludicidade, lazer, diversão, aprendizado, saúde e bem estar através de gincanas e brincadeiras lúdicas, educativas e tradicionais e estimula o convívio social. O objetivo deste trabalho é apresentar e discutir o processo de construção e os resultados do “Projeto de Extensão Pura diversão” bem como suas conquistas e evoluções. As análises foram feitas com a amostra de um total de 5 encontros em parceria com o Ciclo de Cuidados Com as Mulheres com 118 crianças, faixa etária de 5 a 14 anos, sendo 48,3% meninas e 51,7% meninos e média de 40 crianças por encontros, além de outros 5 encontros na comunidade com média total de 50 crianças. Foram adquiridos 4 kits de materiais de apoio para as atividades e criação de logomarca do projeto. As crianças vivenciaram oficinas de slackline, brincadeiras orgânicas, oficinas de reciclagem, fortalecendo cada vez mais o vínculo criado com a equipe, além do fortalecimento do sentimento de alegria, empoderamento e pertencimento, além da troca de saberes para a equipe participante.
Oficinas do cuidado com idosas institucionalizadas em Ouro Preto - MG - Relato de experiência
Authors: Paula Carmen Aparecida , Binda Nancy Scardua , Nascimento Renata Cristina Rezende Macedo do , Rodrigues Marcela Cristine de Carvalho , Paiva Beatriz Campos , Almeida Andressa Victoria de , Assis Aisllan Diego de
Published: October 2024

Este trabalho descreve uma experiência de atividades voltadas para o estímulo e desenvolvimento de habilidades de coordenação motora, cognitivas e sociais, individuais ou em grupos, tendo como objetivo estimular o convívio social das idosas residentes em uma instituição de longa permanência com vistas a melhorar a qualidade de vida, a partir de oficinas interativas. As atividades desenvolvidas com as idosas residentes na Instituição de Longa Permanência Para Idosos fundamentaram na acolhida, como forma de humanização do cuidado em saúde, e foram realizadas adotando práticas grupais e integrativas para promoção da saúde, prevenção de adoecimentos, com foco no acolhimento das pessoas e suas vulnerabilidades. Nas atividades iniciais, algumas participantes se mostraram apáticas, porém à medida que as atividades foram sendo desenvolvidas, as idosas ao serem estimuladas, mostraram diferentes habilidades e potencialidades, principalmente artísticas e culturais, bem como o desejo de sair do sedentarismo e do rótulo de incapazes que muitas vezes foram atribuídos a elas. O desenvolvimento das oficinas evidenciou que idosas residentes em Instituições de Longa Permanência, mesmo sendo bem acompanhadas por uma equipe multiprofissional, necessitam de uma atenção mais individualizada, considerando suas subjetividades e particularidades nos desafios do dia a dia.
Ciclo de cuidados das mulheres de Antônio Pereira: Empoderamento feminino
Authors: Rainá Rabeshe
Published: October 2024

No distrito de Antônio Pereira, Ouro Preto, Minas Gerais, identificou-se a necessidade de melhoria na qualidade de vida das mulheres em situação de vulnerabilidade social. Criou-se então um projeto de intervenção vinculado a um programa de extensão e pesquisa baseado em um ciclo de encontros visando o acolhimento e empoderamento feminino. O objetivo do Ciclo de Cuidados das Mulheres de Antônio Pereira foi promover o acolhimento e empoderamento feminino, resgatando memórias, promovendo a cidadania e a profissionalização, além de fortalecer o coletivo feminino. O ciclo de encontros visa mitigar os desafios enfrentados por essas mulheres, impactadas pelos danos e dependência da mineração industrial no distrito. A primeira edição do Ciclo de Cuidados, iniciada em março de 2023, abordou temas como cidadania, educação, empreendedorismo, direitos humanos e lazer, culminando em um dia de realce da beleza e um desfile, atendendo 30 mulheres do distrito em oito encontros. Uma segunda edição está planejada para 2024, com espaços individuais de escuta, ouvidoria e assessoria jurídica para mulheres de Antônio Pereira. Através da criação de diálogo, apoio mútuo, iniciativas de geração de renda, saúde e lazer, proporcionaram-se às mulheres encontros que promoveram o desenvolvimento pessoal e comunitário.
Oficinas profissionalizantes e feira de Panificação e quitandas no distrito de Antônio Pereira, Ouro Preto, MG: relato de experiência
Authors: De Mari Victoria , Ferreira Januzzi Campos de Almeida Cecília , Costa Miriã Elisa Silva e , Laureano Silva Filipe , Viana Malta João Carlos , Luís Silva André , Andreoli Cristiana Santos , Vieira Silvia Mendonça , Diego Assis Aisllan
Published: October 2024

A comunidade de Antônio Pereira, distrito de Ouro Preto é afetada pelos problemas causados com a exploração mineral em seu território. Este projeto teve como objetivo capacitar mulheres em estado de vulnerabilidade social e assim proporcionar uma possibilidade de geração de renda para suas famílias. Foram realizadas oficinas práticas de pães e quitandas e aulas sobre o empreendedorismo para quatro turmas ao longo dos anos de 2022 e 2023, capacitando17 mulheres. Quatro feiras no distrito também foram realizadas para comercialização de produtos elaborados pelas alunas, com a doação de todo o material necessário para a produção utilizando o recurso disponível para o projeto. Houve participação de outros feirantes, principalmente artesanato e alimentos e bebidas, aumentando o movimento e visibilidade destes eventos. Materiais e equipamentos também foram adquiridos para equipar a “padaria comunitária” Pretende-se, ao longo do 2024, capacitar feirantes que produzem e comercializam alimentos nas Boas Práticas de Fabricação, bem como lançar um livro das quitandeiras de Antônio Pereira.