bluuebunny/crossref_metadata_2025 huggingface dataset:
Penilaian Presentasi Infografis Materi Pedagogi Seni Pertunjukan untuk Mendukung Pembelajaran Zoom Meeting
Authors: Pratama Ujang Nendra , Herbekti Silvia
Published: May 2022

Pembelajaran utama secara daring sampai saat ini masih dilaksanakan di semua tingkat dan jenis pendidikan, tak terkecuali di pendidikan tinggi kesenian. Terkait hal ini, pengajar perlu memanfaatkan teknik-teknik instruksional yang dapat mendukung kinerja secara daring. Peneliti telah melakukan implementasi pendekatan synchronous pembelajaran daring dengan aplikasi Zoom Meeting di lingkungan Prodi Pendidikan Seni Pertunjukan. Berangkat dari hal tersebut, maka telah diterapkan teknik instruksional dengan presentasi infografis untuk penyampaian materi melalui kelas Zoom. Penelitian ini bertujuan untuk mengetahui kelayakan desain presentasi berbasis infografis tentang materi pedagogi (pendidikan dan pembelajaran) seni pertunjukan dari sudut pandang ahli media. Metode riset yang dilakukan adalah validasi ahli atau survei pakar (experts judgement survey). Pengambilan data melalui survei daring dengan instrumen kuesioner yang terdiri dari 4 kategori penilaian (total item 32). Sumber data adalah sepuluh ahli media dari kalangan dosen Teknologi Pembelajaran. Analisis data dilakukan melalui penjumlahan rerata skor hasil survei, kemudian membagi ke setiap total kategori dan total skor per responden, serta mengonversi ke 4 kategori nilai kualitas. Hasil penelitian menunjukkan bahwa presentasi infografis yang diimplementasikan memiliki nilai kelayakan tinggi. Pembuatan presentasi infografis dalam implementasi penelitian ini menyesuaikan berbagai macam rekomendasi dari penelitian sebelumnya, sehingga media yang dihasilkan memiliki kelayakan tinggi dari persepsi ahli. Studi ini menyimpulkan bahwa desain presentasi berbasis infografis tentang materi kependidikan dan pembelajaran untuk pendidikan seni pertunjukan, telah dinyatakan layak dari sudut pandang ahli media. Hasil studi ini diharapkan dapat memberikan implikasi pada pengajaran materi kependidikan dan pembelajaran untuk kawasan bidang studi lain yang masih relevan. Penelitian mendatang dapat diarahkan untuk survei persepsi dari sudut pandang peserta didik yang menjadi audiens dari pemanfaatan media terkait.

 
ANALISIS EFEKTIVITAS BELAJAR SISWA DALAM PEMBELAJARAN ONLINE DI MASA PANDEMI COVID-19
Authors: Herlina Herlina , Husnul Husnul
Published: May 2022

Penelitian ini bertujuan untuk mengetahui efektivitas belajar siswa melalui metode pembelajaran daring pada masa pandemi covid-19 di kelas V SD Inpres Bumi Sagu. Penelitian ini merupakan penelitian kualitatif deskripsi dengan metode studi analisis. Subjek dalam penelitian ini adalah seluruh siswa kelas V SD Inpres Bumi Sagu dengan jumlah total 24 siswa yang terdiri dari 13 siswa laki-laki dan 11 siswa perempuan. Penelitian ini adalah studi analisis dimana peneliti ingin melihat bagaimana guru dan siswa memanfaatkan pembelajaran daring selama masa pandemi di kelas V SD Inpres Bumi Sagu. Hasil penelitian menunjukkan bahwa pembelajaran daring dilakukan setiap hari dengan presentase 83.33% menjawab sering, dan 16.67% menyatakan jarang. Terkait dengan penyampaian tujuan pembelajaran oleh guru, 75% siswa menjawab selalu, dan 25% menjawab jarang, sementara untuk penggunaan internet dalam pembelajaran 70.83% siswa menjawab sering, dan 29.17% menjawab jarang. Berdasarkan hasil ini dapat disimpulkan bahwa pembelajaran daring bahwa pembelajaran daring di kelas V SDN Bumi Sagu sangat efektif karena persentase jawaban sering dari komponen pertanyaan mendapatkan respons di atas 50%.
Peluang Dan Tantangan Implementasi Merdeka Belajar Kampus Merdeka (Mbkm) Di Fakultas Teknik Dan Sains UIKA BOGOR
Authors: Hudjimartsu Sahid Agustian , Prayudyanto Muhammad Nanang , Permana Setya , Heryansyah Arien
Published: May 2022

Dinamika dan perubahan yang terjadi saat ini begitu dinamis, terlebih di era revolusi industri 4.0 atau disebut sebagai revolusi digital yang diindikasikan oleh perubahan  yang sangat besar di semua bidang berbasis teknologi. Perubahan juga terjadi di bidang Pendidikan yang mana dituntut dapat berjalan beriringan sesuai dengan perubahan yang ada agar dapat menghasilkan sumber daya daya manusia pendidikan tinggi yang memiliki kualitas tinggi yang juga inovatif, kreatif, dan efisien. Oleh karena itu, untuk menghadapi kondisi tersebut Kementerian Pendidikan dan Kebudayaan membuat kebijakan terkait Pendidikan diantaranya kebijakan Merdeka Belajar Kampus Merdeka (MBKM). Kebijakan MBKM memberikan kebebasan dan otonomi kepada Lembaga Pendidikan, dan merdeka dari birokratisasi, dosen dibebaskan dari birokrasi yang berbelit serta mahasiswa diberikan kebebasan dalam memilih bidang yang mereka minati. Terjadi pergeseran bentuk pembelajaran sehingga menjadi peluang dan tantangan bagi perguruan tinggi dalam memfasilitasi model pembelajaran yang mampu menghadapi tantangan jaman dan menuju kampus yang bermutu dan bereputasi.
Mengatasi Problematika Pembelajaran Daring Pada Siswa Sekolah Dasar Melalui Pendekatan Psychological Well Being (PWB)
Authors: Asmahasanah Salati , Priatna Oking Setia , Supriatna Irfan
Published: May 2022

Tujuan peneltian ini adalah untuk menggambarkan berbagai problematika dampak dari pembelajaran daring serta membahas proses penanganan melalui pendekatan Psychological Well Being (PWB) pada anak sekolah dasar dan tergambar dengan jelas fenomena perubahan perilaku siswa akibat pembelajaran daring. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan metode deskriptif. Peneliti memperoleh data bahwa sebagian besar guru memanfaatkan gawai (HP) dalam pembelajaran online namun hal yang mengkhawatirkan adalah adanya generasi dengan learning loss karena penurunan capaian belajar.  Banyak siswa yang mengalami kesulitan konsentrasi, dan rasa berat sekali beban karena banyak sekali penugasan dari guru guna untuk menuntaskan kurikulumnya, dan juga peningkatan rasa stres, cemas, apatis dan jenuh yang dialami siswa. Hasil penelitian yang ditemukan bahwa Psychological Well Being (PWB) dapat membantu anak untuk menumbuhkan emosi positif, kepuasan hidup dan kebahagiaan mengurangi berprilaku negatif dan dapat mengendalikan emosi dengan baik.
THEORETICAL FUNDAMENTALS OF INVESTMENT POLICY OF BUSINESS ENTITIES
Authors:   University of Customs and Finance, Knish Oleksandr , Paderin Ivan ,   University of Customs and Finance, Zhadko Konstantine ,   University of Customs and Finance
Published: May 2022

The problems of investing in the economy have always been the focus of both economic science and public administration practice. The problems of investing in the economy have always been in the center of respect for both economic science and the practice of state administration. The subjects of the government in Persh Cherga praise such problems as the effective management of investment activities; the need to search for effective important development of investment activities; the need for the formation of an efficient system of investment activity as a platform for expanding the recruitment base; the need for concentration of respect in the minds of today for the creation of a system of investment security expansionactivity of subjects. The article reveals the essence of investment, investment policy and activity, influencing the subjects of state rule. It has already been brought to light that activity, as it is connected with investments, is necessary for the economic growth of the state. It is indicated that for the modernization of the economy, an active investment activity is required. It has been established that the investment activity is oriented towards the goals to be achieved: it is timely updating the main production costs, and improving the technology. possession of the virobnitstvі, yakі lead to positive changes in the investment policy. The need for investment in the sphere of government was brought. The article reveals the essence of investment, investment policy and activity, influencing the subjects of state rule. It has already been brought to light that activity, as it is connected with investments, is necessary for the economic growth of the state. It is indicated that for the modernization of the economy, an active investment activity is required. It has been established that the investment activity is oriented towards the goals to be achieved: it is timely updating the main production costs, and improving the technology. possession of the virobnitstvі, yakі lead to positive changes in the investment policy. The need for investment in the sphere of government was brought. The issues covered in the article are relevant in the current development of the country, businesses and other businesses in the need to make full use of investment opportunities through financial investment, creating a civilized stock market, expanding ways and forms of investment financing.
ORGANIZATION OF PERSONNEL BUSINESS CAREER MANAGEMENT SYSTEM
Authors:   Kamianets-Podilskyi National Ivan Ohiienko University, Oliynuk Nadiya
Published: May 2022

The article examines the features of effective business career management, factors of career formation and planning. The need to improve the management system of business career of the staff in the organization, due to changes in the structure of the labor market, the need to provide human resources and new requirements for staff. The organization of the business career management system reflects a set of activities carried out by the personnel department of the organization and includes planning, organization, motivation and control of career growth. The directions of internal organizational career are determined, which consists of successive changes in the stages of professional development of an employee within one organization (vertical, horizontal, purposeful) and professional career of personal work. The factors of effective construction of a business career that are directly related to the person (abilities, interests, motivation, decision-making to change roles and status, etc.) and factors related to the interaction of the individual with the environment are summarized. Factors inhibiting business careers that slow down the process of development until its termination, change of direction and other manifestations are also analyzed. Depending on the origin of the inhibition factors can be: physical, psychological, social and ideal. The organization of work on planning and implementation (management) of the employee's career is systematized. Career planning in the organization can be done by the HR manager, the employee himself, his immediate supervisor, as well as by comparing personal intentions in the field of his career with the ability to meet them with available methods. Heads of departments must provide their employees with information about the needs and capabilities of the organization in staffing. Careers should be built on the shared participation of both participants and their shared responsibility for their own part of the organization of this career planning process. A business career is a component of inner attitude and behavior, change of skills and formation of competencies related to the activity. The importance of the career chart, which is a list of professional and job positions in the organization, the possibility of mobility and stimulate personal career planning. The process of personnel career management is determined by a set of means of influence and personnel technologies that provide management of professional experience of personnel in the organization.
CREDIT UNIONS IN UKRAINE: STATE AND PROSPECTS OF DEVELOPMENT
Authors:   Oles Honchar Dnipro National University, Dereza Viacheslav
Published: May 2022

The article considers the essence and importance of credit unions in the development of the economy, explores and identifies the main issues of development of these market participants, offers proposals to improve the efficiency of credit unions in Ukraine and assesses the prospects for their development. As a result of our research, we have identified the main features and principles of credit unions. The article notes the differences between credit unions and banking institutions. The role of credit unions in the structure of financial services markets has been determined. It is emphasized that credit unions play an important role not only in the economic development of the state, but also have a significant socio-economic importance for the progressive processes in the country. The key factors influencing the development of credit-cooperative movement and determining the role of credit unions are the following: availability of financial resources of credit unions in comparison with other subjects of financial services markets, which is conditioned by the economic development level of the state; understanding of the co-operative nature of credit unions by the general public as a non-profit public-financial organization, which furthermore greatly promotes institutions, fosters trust and enhances their social significance; proper system of state supervision and regulation of credit cooperation. Credit unions defend the interests of the Union, its shareholders, lenders and national interests in the credit relations process. Credit unions are regarded as an important part of financial market infrastructure by the article author. Such institutions created by a group of people, not for profit, but for the provision of services to its members. The main prerequisite for the effective functioning is the fulfillment of key performance indicators of credit unions. The reasons for Ukraine's lag behind global trends in the development of credit unions are identified, measures are planned that could contribute to the expansion of effective credit unions, the implementation of positive quantitative and qualitative changes in their activities in the coming years.
ABOUT THE FEATURES OF THE RISK PROFILE OF DOMESTIC BANKS
Authors:   University of Customs and Finance, Lysiak Liubov , Guba Mariya ,   University of Customs and Finance
Published: May 2022

The country's banking system in the process of performing its functions is always exposed to a significant number of both external and internal risks, which can significantly affect the efficiency of its activities. NBU began introducing a gradual transition to banking supervision based on bank risk assessment in 2015. The basic principles and tools of the risk-oriented approach are based on the assessment of banks' risks and the quality of their management using the SREP methodology. The use of new risk-oriented instruments has been enshrined in law in the form of bank assessment and in-house inspection of the bank. Given the objective nature of the existence of risks during the performance of banks' activities, it is necessary to create an appropriate mechanism to take them into account when making certain decisions related to the bank's management process, namely the risk management system. This is also due to the fact that banks in modern conditions have more significant requirements for the depth, relevance and adequacy of their approaches to the construction and implementation of banking risk management procedures, risk profile, taking into account the specifics of their activities, volume and nature of products and services, that is business model. In particular, modern approaches to bank valuation have been introduced, namely SREP analysis. SREP analysis is a continuous process based on the requirements of the European Banking Authority, conducted by the NBU on the basis of the approved methodology and takes into account the analytical information of its departments about banks, and covers all banks operating in the country’s banking system. This analysis is a comprehensive process that takes place on January, 1 of the calendar year and is subject to regular updates. The estimate obtained should be updated quarterly, based on changes in quantitative indicators and taking into account new relevant information of a non-financial nature. Based on the results of the analysis, the strategy of banking supervision is determined. In addition, the NBU regularly prepares Financial Stability Reports, which provide information on existing and potential risks that may threaten the stability of financial system of Ukraine.
IMPROVEMENT OF ACCOUNTING AND ANALYTICAL PROVISION OF FORMATION AND EXECUTION OF ESTIMATES AND EXPENDITURES OF BUDGET INSTITUTIONS
Authors:   Simon Kuznets Kharkiv National University of Economics, Shevchenko Iryna , Ryzhikova Natalia ,   State Biotechnological University
Published: May 2022

The current state and development of market relations in Ukraine leads to improved management of all economic entities, especially budget institutions, which are the primary link in the budget system. The source of funding for their activities are budget funds allocated to these institutions from the budgets of different levels, the amount of which is determined by the main financial document – the budget. Rational and effective management of financial flows of the state is possible with a well-established system of formation and use of funds by budgetary institutions that ensure the performance of functions assigned to the state. In this context, the role and importance of accounting and analytical support for the formation and implementation of estimates of revenues and expenditures of budgetary institutions is growing significantly. Misuse, inefficient and illegal use of public funds by their managers at various levels is quite common. This issue is especially relevant in conditions of financial and economic instability, as the formation of the revenue side of budgets at all levels is influenced by a combination of many external and internal factors, including the implementation of budget estimates. The concept of "organization of accounting and analytical support" included a new feature, which more accurately characterizes the definition under study. The difference between the new definition is that accounting and analytical support is understood not as a result (as in most definitions), but as a process of bringing information to users ("combination of information flows"). The components of the organizational and information model of the analysis of the budget are objects, subjects of analysis, the system of economic indicators, information support, methods of analytical research, generalization and implementation of analysis results. Thanks to the analysis it is possible to exercise effective control over the distribution and use of available budgetary resources of the institution. An equally important component is the organization of accounting in the formation and implementation of estimates of revenues and expenditures of budgetary institutions in the direction of accounting automation, which will expand budget management – control over the implementation of monthly expenditures approved by the budget and allocation plan for the current year.
MODELS OF ANALYSIS OF INFLATION EXPECTATIONS
Authors:   Vasyl Stefanyk Precarpathian National University, Kramar Vitalii , Pilko Andriy ,   Vasyl Stefanyk Precarpathian National University
Published: May 2022

Households, firms, and financial market participants adjust their behavior according to their own expectations about future price increases. Inflation expectations often lead to higher actual prices. Accordingly, inflation expectations are characterized by self-fulfilling and they are one of the factors influencing the future level of inflation. It is important for central banks to monitor inflation expectations and shape them in the desired way through their activities and communications through the monetary transmission expectations channel. Therefore, empirical conclusions about the inflation expectations of agents are significant and relevant for monetary policy. This paper presents the results of the analysis of existing types of models for the analysis of inflation expectations with the subsequent implementation of individual models on the data of inflation expectations, which are monitored by the NBU. Particular attention is paid to the analysis of models of inflation anchoring, models of assessment of rationality and shift of inflation expectations, as well as models of forecasting inflation expectations. The use of applied econometric tools allowed to obtain competitive science-based results. In particular, the calculations showed that the highest sensitivity to inflation among all groups of respondents is shown by households, and the least sensitive according to the results of the model are inflation expectations of financial analysts. The developed forecast models have acceptable forecasting properties and can be used to forecast inflation expectations. The analysis showed that the degree of anchoring of inflation expectations at the level of the Central Bank's inflation target determines the effectiveness of monetary transmission through the expectations channel, and reflects the level of confidence of economic agents in monetary policy. In the absence of trust in the Central Bank, inflation expectations can be adaptive, i.e. those that are formed under the influence of past inflation. Under such conditions, the effectiveness of the transmission mechanism of monetary policy weakens, and current inflation, due to deteriorating expectations, becomes more sensitive to the effects of various shocks. On the basis of the analyzed literature the main directions of research of inflation expectations, and also the basic approaches to construction of models of the analysis of inflation expectations are presented.
THE PARADIGM OF THE EU’S «NEW INNOVATIVE WORLDVIEW»
Authors:   Uzhhorod National University, Zayats Olena , Yarema Tomash ,   Uzhhorod National University
Published: May 2022

The essential conceptual component of the innovation power of the EU economy in the last decade is the paradigm of the "new innovative worldview", which is based on the conceptual apparatus of "open innovation", called "Open Innovation 2.0». The research aims to study the modern paradigm of the "new innovative worldview" of the European Union. The research methodology involved extensive analysis, synthesis, comparison, and generalisation tools. The article examines the global paradigm of the "new innovative worldview" of the European Union. It defines the main features that characterise the "Open Innovation 2.0" of the EU. The paper proves that knowledge and innovation remain priority areas for developing the innovation power of the European Union. The emergence and development of "open innovation" are associated with a synergistic worldview of the evolution of economic systems and the deep media informatisation and digitalisation processes, which stimulate the computer revolution and virtualism. It demonstrates that the characteristic feature of economic development of EU member states is openness to change, the desire to improve the quality of life, the level of competitiveness of products, services and all types of resources provided by innovation as one of the most critical drivers of social development. It analyses the innovation power of the European Union member states according to the European Innovative Scoreboard. The article presents the rating of EU member states on innovation force. It founds that Sweden is still the leader in innovation in the EU. It considers the European Union's innovation strategies "Europe 2020" and the new six-year Horizon Europe – the EU research and innovation framework programme 2021–2027. It is concluded that in current conditions, the global paradigm of the "innovation worldview" of the European Union is that by pursuing an active policy of dissemination of innovation and new knowledge, EU member states contribute to the fact that regional policy, previously redistributive, all acquires more features of structural approach. The synergetic effect is achieved by combining member states' own national innovation strategies and participating in supranational, pan-European innovation programs.
THE ECONOMIC STRUCTURE ANALYSIS AT THE REGIONAL LEVEL
Authors:   Ivano-Frankivsk National Technical University of Oil and Gas, Savko Oksana , Havadzyn Nataliia ,   King Danylo University
Published: May 2022

The economic structure of the Ivano-Frankivsk region was analyzed by types of economic activity for 5 years. The largest share is occupied by such activities as: processing industry, agriculture, forestry and fisheries, mining and quarrying, supply of electricity, gas, steam and air conditioning, construction, wholesale and retail trade; repair of motor vehicles and motorcycles. Other activities take from 1–5%, which is a small share and require appropriate measures for further development. Analysis of structural shifts in output by types of economic activity, which showed that the components with the “+” sign show an increase in the change in the share of the structural part, in particular, these are such types of management as: mining and processing industry, water supply; sewerage, waste management, real estate operations, public administration and defense; compulsory social insurance, information and telecommunications and others. The same components, with the “-” sign, respectively, show a decrease in the change in the share of one or another type of economic activity in the overall structure, in particular: agriculture, forestry and fisheries, construction, wholesale and retail trade; repair of motor vehicles and motorcycles, supply of electricity, gas, steam and air conditioning, transport, warehousing, postal and courier activities, health care and social assistance. To assess the intensity of structural shifts in the whole population, the linear and quadratic coefficients of absolute structural shifts were calculated. Which showed that there were changes in the structural relation of the share of output by types of economic activity of the region, in particular, in construction and processing industry. The use of statistical methods made it possible to investigate the state of the priority activities of the economy of the Ivano-Frankivsk region, the structure and identify trends in further development. However, the strategic task of the region is the effective use of the existing potential (resource, production, labor, material and technical, financial) to improve its socio-economic situation.
STATE POLICY IN THE FIELD OF PATRIOTIC EDUCATION
Authors:   Sumy National Agrarian University, Slavkova Olena , Fihurna Mariia ,   Sumy National Agrarian University
Published: May 2022

The article proves the need to cultivate patriotism through public policy, especially in modern wartime Ukraine. A successful path to victory is possible if public policy promotes the development of a system of national and patriotic education. We believe that in the conditions of modern development the idea of patriotism should be the core around which high ideological positions are formed, as well as the aspirations, readiness and ability of all people to actively work for the benefit of the homeland. It is proved that the target audience of the main document, which sets out the directions of state policy on patriotic education are young people, and such segments of the population as persons over 35 years of age, which make up 61.1 percent of the population are not involved. Based on a total population of 41.1 million at the beginning of 2022, measures aimed at promoting Ukrainian youth NGOs banned and persecuted by the occupation and Soviet regimes, including the Ukrainian Plast movement (Plast) and the Scout movement, Unions of Ukrainian youth that have survived abroad and resumed their activities in Ukraine with independence should be covered in 2022, only 0.7 percent of the population, which in our opinion is very small, given that the percentage of young people aged 15 to 35 is 24.7 percent. The planned level of youth coverage of measures aimed at increasing the number of young people ready to fulfill the duty to protect the independence and territorial integrity of Ukraine is quite low. Calculations show that out of the total number of young people (10.1 million people), only 239.6 thousand people will join the relevant activities. On average, 19.9 thousand people per month and 163 people per territorial community. It is determined that the influence of the state on the process of patriotic education is the use of appropriate mechanisms that contribute to achieving its goals. State mechanisms are closely linked and complementary, and their integrated use contributes to the main goal of public policy. The direction of patriotic educational state policy should be based on the fact that it is primarily national. We see future research on the essence of directions and mechanisms of state policy in the development of patriotic education of all segments of society and not only young people.
Consideraciones del código de ética en el gobierno corporativo en México
Authors:   Universidad de Guadalajara, Rivera Lima Lizette , Perez Casas Erika Viviana ,   Universidad de Guadalajara, Ballesteros Alonso Abraham Emmanuel ,   Universidad de Guadalajara
Published: May 2022

Las crecientes obligaciones en México a partir de 2003 de transparencia, información, materialidad de operaciones y cumplimiento normativo de las sociedades mercantiles replantean la realidad jurídica y organizacional de la persona jurídica, lo cual conlleva la adopción de soluciones no sólo desde el plano administrativo, sino también legal. El presente artículo tiene como propósito analizar el código de ética dentro del gobierno corporativo de la sociedad conforme a la legislación vigente a nivel federal en México durante 2021 como medida de control interno y externo. El estudio es de tipo cualitativo con alcance descriptivo realizado a través del método de la hermenéutica jurídica y la técnica de investigación documental. Se concluye que el código de ética es un medio de control interno que a nivel jurídico puede ayudar a la sociedad a disminuir su exposición al riesgo al establecer una guía de acción para las personas que se encuentran en esta así como en sus relaciones con terceros.
Análisis comparativo del régimen fiscal de una sociedad por acciones simplificada 2021-2022
Authors:   Universidad de Guadalajara, Rivera Lima Lizette , Valenzuela Rodríguez Sonia ,   Universidad de Guadalajara, Muñiz Cervantes Juan Antonio ,   Universidad de Guadalajara
Published: May 2022

Esta investigación tiene como objetivo comparar el régimen fiscal de una Sociedad por Acciones Simplificada (SAS) dentro del Régimen General de Personas Morales y el Régimen Simplificado de Confianza (RESICO) para personas morales, delimitando la investigación a un estudio de caso en lo particular sobre las disposiciones del Impuesto Sobre la Renta vigentes en diciembre de 2021 y enero de 2022. El trabajo fue un estudio cualitativo usando la metodología del análisis FODA (fortalezas, oportunidades, debilidades y amenazas), empleando la técnica de investigación documental y la observación directa. Los hallazgos mostraron que la ventaja principal del RESICO frente al Régimen General es que si la SAS supera los 5 millones de pesos en ingresos, el régimen fiscal podría seguir siendo el mismo aunque la sociedad se transforme y podría seguir con sus beneficios hasta que no rebase los ingresos por 35 millones de pesos.
Developing the polycystic kidney disease interactome
Authors: Brauer Mackenzie
Published: May 2022

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disease causing numerous renal cysts to form leading to adult renal failure. The PKD-causing genes, polycystic kidney disease-1 and -2 (PKD1 and PKD2), encode for proteins polycystin-1 and -2 (PC1 and PC2). These proteins form a complex through their C-termini at cilia with mutations abolishing their interaction and impairing ciliary localization. We report the first use of proximity-dependent biotinylation for identification (BioID) to  characterize the PC1 PC2 C-terminal complex binding partners in HEK 293 cells. We identify high- confidence interacting partners including an enrichment of cilia-related, transporter activity and  trafficking genes. We report interesting PC1 interactions including Biogenesis of Lysosome-Related Organelles Complex-1 (BLOC-1) subunits and BLOC-One-Related Complex (BORC) subunits. We also report endoplasmic reticulum (ER)-related proteins that likely contribute to PC2 ER localization and function. Overall, this research hopes to contribute information to how PC1 and PC2 traffic and function at cilia.
Real options valuation with duopoly game-theoretic approach and regime switching
Authors: Diaz Jorge Restrepo
Published: May 2022

New product demand continuously fluctuates through the life of the product. As a result, markets usually experience high volatility due to fluctuating demand. Hence, organizations must rapidly adapt and be flexible with such volatility. Management decisions cannot rely on traditional models that assume economic variables to be constant over time. Therefore, companies must advance and implement adequate strategies in resource allocation that help them survive in uncertain markets, and mitigate the associated risk from market uncertainty. This research aims to investigate product introduction strategies where two micro-economic theories can be applied: game-theoretic approach and a real options valuation. Specifically, a real options valuation framework with a flexible capacity that can be used to calculate the Net Present Value (NPV) and the optimal initial capacity to invest in a product, which is being introduced in a duopoly environment, is proposed. This framework is based on game theory applied to a duopoly market. A stochastic product life cycle characterized by a regime-switching approach and the consideration of two different game-theoretic models for the cases where competitors have perfect or imperfect information in the market are the main focal points of our study. Subsequently, different numerical examples comparing the results of NPV and optimal initial capacities from both game-theoretic models are presented. It is observed that the leader in the model with perfect information has an important advantage over its opponent because this company makes the first move to establish quantity to supply. Also, the leader in perfect information game has an advantage over the game with imperfect information since decisions with imperfect information have to be made simultaneously, and players need to balance all possible outcomes when making a choice. Consequently, in both models, one of the competitors obtains its maximum NPV when the other invests in the lowest level of capacity. Lastly, expansion and contraction costs play a critical role in the strategy of resource allocation as these costs are involved in capacity flexibility. Therefore, firms can adjust their production when product demand varies to maximize profits.
Formación de cultura en propiedad industrial. Desafío conceptual en la literatura actual
Authors: Bicet Dorzón Osmany , Mariño Vivar Jorge Luís
Published: May 2022

Este artículo tiene como propósito realizar una revisión de la literatura que contribuya al desarrollo de investigaciones orientadas a la gestión de proceso formativo de cultura en propiedad industrial. Para su elaboración se escogió como fuente los artículos indexados en el índice bibliográfico Scielo, Redalyc y otras. La exploración abarcó trabajos publicados a partir de 2003, año en que la OMPI comenzó a sensibilizar al público respecto a la educación y formación de cultura en propiedad intelectual. El estudio se sistematizó en etapas, se identificaron las palabras claves; se procedió a la búsqueda de la información relevante, se determinaron los criterios de selección, que posibilitaron el análisis de la documentación acopiada; finalmente se elaboró el documento final. El artículo aborda la relación existente en la literatura entre el concepto de cultura en propiedad industrial y los aspectos de carácter formativos a considerar en escenarios educativos.
SURVEI KUALITAS PELAYANAN PEMILU SERENTAK 2019 SEBAGAI BAHAN EVALUASI BERBASIS RISET BAGI KPPU (TPS 42 dan 43 Kelurahan Bandulan Kota Malang)
Authors: Hellyani Catharina Aprilia , Wahyono Seno Aji , Putrianto Novenda Kartika
Published: May 2022

This study aims to measure 5 levels of service quality to find out how good the service was in the 2019 Simultaneous Election. Service quality was measured by the TERRA dimensions, namely tangibility, empathy, responsiveness, reliability, and assurance with a Likert measurement scale. The object of this research was 280 residents who were active voters at TPS 42 and 43, with a sample of 60 people. The data that has been obtained was processed into descriptive statistical data which were used as a database to determine the dimensions of TERRA which are still not optimal in the next general election. Descriptive data processing showed that most of the respondents strongly agree with the statement of service quality related to the TERRA dimension. The measurement result showedthat the service quality of TPS 42 and 43 is in the high range scale. This shows that the quality of service at TPS 42 and 43 was very good and complies with KPPS guidelines so that it should be used as a role model for other TPS.
ANALISIS PENGARUH IDENTITAS, CITRA DAN KEPERCAYAAN TERHADAP LOYALITAS MEREK
Authors: Wahyono Seno Aji , Hellyani Catharina Aprilia , Sin Liem Gai
Published: May 2022

This study aims to analyze the influence of identity, image, and trust on brand loyalty Honda motorcycles in Malang. Using quantitative methods with a population of 2,364 users in Malang City, a sample of 100 respondents was taken through purposive sampling. The data was obtained through a questionnaire survey which was tested with multiple linear regression. The results show that brand identity affects brand loyalty with a significance of 0.000 and a regression value of 0.376; in addition, the brand image has a significant value of 0.001 and a regression value of 0.341; brand trust has a significance value of 0.005 and a regression value of 0.295; and brand identity, brand image, and brand trust simultaneously affect brand loyalty with a significance value of 0.000 which indicates a positive relationship to brand loyalty. This is due to the advantages of Honda motorcycles in terms of advanced technological features and saving gasoline, as well as attractive appearance and design
DETEKSI DINI PENINGKATAN KINERJA KARYAWAN
Authors: Anjarwati Desi , Widowati Sri Yuni , Santoso Aprih , Wahdi Nir Setyo
Published: May 2022

The purpose of this study was to analyze the impact of the work environment, leadership and motivation on the performance of the Sewing Section employees of PT Hop Lun Indonesia. This research was a survey with a total sample of 93 employees. The data was collected through the distribution of a list of questions, while the later data will be analyzed using multiple regression tests. The results show that the work environment, leadership, motivation have a significant and positive impact on employee performance with a coefficient of determination of 0.623 which means that the work environment, leadership and motivation factors have an impact on the performance of employees in the sewing section at PT Hop Lun Indonesia by 62.3% while the difference is 37.7. % can be influenced by other variables such as incentives and organizational culture.
Examining the Cellular Transport Pathway of Fusogenic Quantum Dots Conjugated With Tat Peptide
Authors: Dai Jie , Wang Jun , Yang Xuan , Xu Zixing , Ruan Gang
Published: May 2022

Understanding the underlying transport mechanism of biological delivery is important for developing delivery technologies for pharmaceuticals, imaging agents, and nanomaterials. Recently reported by our group, SDots are a novel class of nanoparticle delivery systems with distinct biointerface features and excellent fusogenic capabilities (i.e., strong ability to interact with the hydrophobic portions of biomembranes). In this study, we investigate the cellular transport mechanism of SDots conjugated with Tat peptide (SDots-Tat) by live-cell spinning-disk confocal microscopy combined with molecular biology methods. Mechanistic studies were conducted on the following stages of cellular transport of SDots-Tat in HeLa cells: cellular entry, endosomal escape, nucleus entry, and intranuclear transport. A key finding is that, after escaping endosomes, SDots-Tat enter the cell nucleus via an importin β-independent pathway, bypassing the usual nucleus entry mechanism used by Tat. This finding implies a new approach to overcome the nucleus membrane barrier for designing biological delivery technologies.
Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
Authors: Hua Rui , Gu Sumin , Jiang Jean X.
Published: May 2022

Connexin 43 (Cx43) is the predominant connexin subtype expressed in osteocytes. Osteocytes, accounting for 90%–95% of total bone cells, function as orchestrators coordinating balanced activity between bone-resorbing osteoclasts and bone-forming osteoblasts. In this study, two newly developed osteocytic cell lines, OCY454 and IDG-SW3, were used to determine the role of Cx43 gap junctions and hemichannels (HCs) in the regulation of osteoblast to osteocyte differentiation. We found that the Cx43 level was substantially increased during the differentiation of IDG-SW3 cells and is also much higher than that of OCY454 cells. We knocked down Cx43 expression using the lentiviral CRISPR/Cas9 approach and inhibition of Cx43 HCs using Cx43 (E2) antibody in IDG-SW3 cells. Cx43 knockdown (KD) or Cx43 HC inhibition decreased gene expression for osteoblast and osteocyte markers, including alkaline phosphatase, type I collagen, dentin matrix protein 1, sclerostin, and fibroblast growth factor 23, whereas increasing the osteoclastogenesis indicator and the receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG) ratio at early and late differentiation stages. Moreover, mineralization was remarkably attenuated in differentiated Cx43-deficient IDG-SW3 cells compared to ROSA26 control. The conditioned medium collected from fully differentiated IDG-SW3 cells with Cx43 KD promoted osteoclastogenesis of RAW264.7 osteoclast precursors. Our results demonstrated that Cx43 HCs play critical roles in osteoblast to osteocyte differentiation process and regulate osteoclast differentiation via secreted factors.
Thrombospondin-1 Signaling Through the Calreticulin/LDL Receptor Related Protein 1 Axis: Functions and Possible Roles in Glaucoma
Authors: Murphy-Ullrich Joanne E.
Published: May 2022

Thrombospondin-1 (TSP-1) is a matricellular extracellular matrix protein. Matricellular proteins are components of the extracellular matrix (ECM) that regulate key cellular functions and impact ECM organization, but which lack direct primary structural roles in the ECM. TSP-1 expression is upregulated in response to injury, hypoxia, growth factor stimulation, inflammation, glucose, and by reactive oxygen species. Relevant to glaucoma, TSP-1 is also a mechanosensitive molecule upregulated by mechanical stretch. TSP-1 expression is increased in ocular remodeling in glaucoma in both the trabecular meshwork and in the optic nerve head. The exact roles of TSP-1 in glaucoma remain to be defined, however. It plays important roles in cell behavior and in ECM remodeling during wound healing, fibrosis, angiogenesis, and in tumorigenesis and metastasis. At the cellular level, TSP-1 can modulate cell adhesion and migration, protease activity, growth factor activity, anoikis resistance, apoptosis, and collagen secretion and matrix assembly and cross-linking. These multiple functions and macromolecular and receptor interactions have been ascribed to specific domains of the TSP-1 molecule. In this review, we will focus on the cell regulatory activities of the TSP-1 N-terminal domain (NTD) sequence that binds to cell surface calreticulin (Calr) and which regulates cell functions via signaling through Calr complexed with LDL receptor related protein 1 (LRP1). We will describe TSP-1 actions mediated through the Calr/LRP1 complex in regulating focal adhesion disassembly and cytoskeletal reorganization, cell motility, anoikis resistance, and induction of collagen secretion and matrix deposition. Finally, we will consider the relevance of these TSP-1 functions to the pathologic remodeling of the ECM in glaucoma.
Elevated IP-10 at the Protein and Gene Level Associates With Pulmonary TB
Authors: Fisher Kimone L. , Moodley Denelle , Rajkumar-Bhugeloo Kerishka , Baiyegunhi Omolara O. , Karim Farina , Ndlovu Hlumani , Ndung’u Thumbi , Marakalala Mohlopheni J.
Published: May 2022

There is an urgent need for accurate and sensitive diagnostic tools that can overcome the current challenge to distinguish individuals with latent tuberculosis infection (LTBI) from individuals with active tuberculosis (TB). Recent literature has suggested that a group of cytokines may serve as biomarkers of TB disease progression. Using a multiplex ELISA, we quantified 27 circulatory markers present within the unstimulated plasma of individuals in Durban, South Africa who were healthy (n=20), LTBI (n=13), or had active TB (n=30). RT-qPCR was performed to measure gene expression of the cytokines of interest, using RNA isolated from healthy (n=20), LTBI (n=20), or active TB (n=30). We found that at the protein level, IL-1RA, IL-6, and IP-10 were significantly more abundant in participants with active TB (p< 0.05) compared to those with LTBI individuals. IP-10 also showed the strongest association with active TB compared to healthy and LTBI at mRNA level. Our data shows that these proteins may serve as biomarkers of TB at both the protein and gene level.
Early Combination of Albumin With Crystalloid Administration Might Reduce Mortality in Patients With Cardiogenic Shock: An Over 10-Year Intensive Care Survey
Authors: Zou Zhi-ye , Wang Bin , Peng Wen-jun , Zhou Zhi-peng , Huang Jia-jia , Yang Zhen-jia , Zhang Jing-jing , Luan Ying-yi , Cheng Biao , Wu Ming
Published: May 2022

Background

In updated international guidelines, combined albumin resuscitation is recommended for septic shock patients who receive large volumes of crystalloids, but minimal data exist on albumin use and the optimal timing in those with cardiogenic shock (CS). The objective of this study was to evaluate the relationship between resuscitation with a combination of albumin within 24 h and 30-day mortality in CS patients.

Methods

We screened patients with CS from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Multivariable Cox proportional hazards models and propensity score matching (PSM) were employed to explore associations between combined albumin resuscitation within 24 h and 30-day mortality in CS. Models adjusted for CS considered potential confounders.E-value analysis suggested for unmeasured confounding.

Results

We categorized 1,332 and 254 patients into crystalloid-only and early albumin combination groups, respectively. Patients who received the albumin combination had decreased 30-day and 60-day mortality (21.7 vs. 32.4% and 25.2 vs. 34.2%, respectively,P< 0.001), and the results were robust after PSM (21.3 vs. 44.7% and 24.9 vs. 47.0%, respectively,P< 0.001) and followingE-value. Stratified analysis showed that only ≥ 60 years old patients benefited from administration early albumin. In the early albumin combination group, the hazard ratios (HRs) of different adjusted covariates remained significant (HRs of 0.45–0.64,P< 0.05). Subgroup analysis showed that resuscitation with combination albumin was significantly associated with reduced 30-day mortality in patients with maximum sequential organ failure assessment score≥10, with acute myocardial infarction, without an Impella or intra-aortic balloon pump, and with or without furosemide and mechanical ventilation (HRs of 0.49, 0.58, 0.65, 0.40, 0.65 and 0.48, respectively;P< 0.001).

Conclusion

This study found, compared with those given crystalloid-only, resuscitation with combination albumin within 24 h is associated with lower 30-day mortality of CS patients aged≥60. The results should be conducted to further assess in randomized controlled trials.