bluuebunny/crossref_metadata_2025 huggingface dataset:
Echolocation as theory of digital sociality
Authors: Markham Annette N
Published: October 2021

Public attention on disconnection and digital detox focuses on the health and wellbeing associated with disconnecting without much attention on what happens to selfhood or identity when abruptly disconnected. In an age of ubiquitous internet and “always on” use practices, what does disconnection do? Focusing on what happens when we disconnect, at the micro level, reveals interesting echolocative communication patterns otherwise not noticed. Abruptly stopping the continuous call and response pattern of interaction among youth produces deep anxieties and feelings of existential vulnerability that are commonly brushed aside. The work in this article is part of a larger project related to echolocation as a theory of communication. In an era of constant connectivity and “always on” or more importantly, “always available” internet, the seemingly seamless and steady state of connectivity is, at the more granular level, a process of continual echolocation, in the way we might think of sonar, whereby certain animals like bats determine the shape and location of objects in space by sending steady streams of signals and attending closely to the quality of the echo. Echolocation challenges researchers and theorists to reconsider the core elements and processes in an era of continuous, machinic as well as human interaction in multiple and massive networks of information flow. This does not mean we no longer experience dyadic (two person) or intra interactions, of course, but echolocation, the process of moving, navigating, and positioning through radar-like call and response provides a promising model to apply to how humans make sense of who they are in the complexities of continuous and tangled data flows.
Influences of student race/ethnicity and gender on autism special education classification considerations
Authors: Golson Megan E , Haverkamp Cassity R , McClain Maryellen Brunson , Schwartz Sarah E , Ha Jennifer , Harris Bryn , Benallie Kandice J
Published: October 2021

Although the prevalence of autism continues to rise, identification disparities across race/ethnicity and gender persist in schools. The under- and overidentification of specific populations receiving special education services under the classification of autism contribute to misappropriation or lack of intervention services for students. Practicing school psychologists ( N = 229) reviewed one of eight vignettes depicting a student displaying possible autism symptoms that varied only by student race/ethnicity and gender. Afterward, they rated the likelihood that they would consider the classification of autism and their confidence in that likelihood rating. School psychologists were more likely to consider an autism classification for Asian female students than Latinx female students. Confidence in likelihood ratings was higher for Asian students than Black students. School psychologists endorsed specific attention to student problem behaviors with minimal notice of possible contributing cultural and linguistic factors. The results highlight that potential implicit biases and lack of cultural consideration play a role in the identification of autism in schools, which may contribute to the nationally documented race/ethnicity and gender identification disparities.

Lay Abstract

Autism prevalence has continued to rise in recent years. However, females and children from Black, Latinx, and Asian backgrounds are often misidentified or identified less often than White males. These identification disparities make it difficult for children to receive appropriate special education and school intervention services. In this study, school psychologists read a vignette featuring a student with possible autism symptoms. The vignette varied by student race/ethnicity and gender. Afterward, participants rated the likelihood that they would classify the student with autism and their confidence in this rating. Student race/ethnicity and gender influenced both classification likelihood and confidence. These results suggest that school psychologists are influenced by implicit bias and do not fully consider cultural factors in school autism evaluations. This may contribute to identification disparities.
The potential of filtered water in the restaurant industry: A case study in Barcelona
Authors: Anguera-Torrell Oriol , Arrieta-Valle Álvaro E.
Published: October 2021

Bottled water entails an environmental sustainability challenge, and the restaurant industry is a large-scale contributor to this problem as it seems to be reluctant, at least in some countries, to substitute tap water for bottled water. There are two plausible reasons for this; one is that the industry might assume that customers prefer bottled water, mainly because of its taste, and the second is that restaurateurs may be unwilling to forgo the high economic margin from bottled water sales. In this context, filtered water may represent a solution as it is a greener option than bottled water and tastes better than tap water. However, does it represent a satisfying taste option for diners? Moreover, are restaurant consumers willing to pay for filtered water? Given the importance of the answers to these questions, this study proposes to examine whether there are differences between filtered and bottled mineral water regarding their expected and actual taste and customers’ willingness to pay. To this end, this study employed three different experimental groups in an actual fine-dining restaurant in Barcelona. The results show that consumers derive a positive payoff by drinking a more environmentally sustainable option and may even be willing to pay for filtered water. However, there is still room for improvement in filtering systems in regard to the taste of water. These results entail important managerial implications for the restaurant industry since it can become more environmentally sustainable without losing economic profits.
Nostalgic conversations: The co-production of an intervention package for people living with dementia and their spouse
Authors: Dodd Emily , Ismail Sanda , Christopher Gary , Wildschut Tim , Sedikides Constantine , Cheston Richard
Published: October 2021

Objectives

Nostalgic memories are more social than other forms of autobiographical recall, often refer to atypical events, express more positive affect and reflect life as meaningful. Recalling a nostalgic (compared to ordinary) memory increases self-esteem, self-growth, meaning in life and social connectedness for people living with dementia. We set two objectives: to work with people living with dementia to develop an intervention based on nostalgia, and to assess whether couples could engage in nostalgic conversations.

Method

Our research fell into three phases. Initially, we consulted with people living with dementia and with carers to identify the parameters for a nostalgic intervention. From this, we drafted a workbook that contained triggers for nostalgic conversations, which we then took back to the public contributors for refinement. Finally, we trialled the workbook over 5 weeks with six couples, each of which included a person living with dementia. We assessed pre- and post-intervention self-esteem, self-growth, meaning in life and social connectedness for participants with dementia and social connectedness for carers. We then calculated Reliable Change Index scores and established levels of clinically significant change. We also interviewed couples at the end of the intervention to explore its implementation and acceptability.

Results

All six couples could identify nostalgic memories, with five couples successfully integrating the nostalgic conversations into their day-to-day lives. A sixth couple found it difficult to engage fully with the intervention, but still considered it useful. All six couples manifested a reliable change in at least one outcome, with one couple showing reliable change across three outcomes.

Conclusion

The psychological benefits of nostalgia have been robustly demonstrated in laboratory-based studies. This co-production of an intervention that sets nostalgic recall into the context of a conversation has clinical potential but requires further investigation through a larger study.
Measuring social desirability bias: Do the full and short versions of the Marlowe-Crowne Social Desirability scale matter?
Authors: Tan Houng Chien , Ho Jo Ann , Kumarusamy Risidaxshinni , Sambasivan Murali
Published: October 2021

Given the sensitive nature of ethics research, the presence of social desirability bias (SDB) threatens the validity of research findings. As ethics studies often overlook this bias, we aimed to provide evidence that SDB varies across individual and situational factors. We thus investigated the influence of socio-demographic factors and survey modes on SDB. A total of 348 working adults were randomly chosen to participate in either an on-line or off-line survey containing eight versions of the Marlowe-Crowne Social Desirability (MCSD) scale. The reliabilities for the eight versions ranged from 0.35 to 0.81. Statistical tests revealed that different socio-demographic factors influence different versions of the MCSD scale. The results also showed that using on-line surveys minimizes SDB. This study provides practical implications and suggestions for future research.
Attitude Toward Prostate Cancer Screening in Hong Kong: The Importance of Perceived Consequence and Anticipated Regret
Authors: Choi Edmond P.H. , Wan Eric Y.F.
Published: October 2021

There are long-standing debates about the benefits of prostate cancer screening. Conflicting trial results and inconsistent recommendations regarding prostate cancer screening in clinical guidelines highlight the importance of patient factors that influence decision making in prostate cancer screening. Attitude is an important factor associated with cancer screening. However, attitudes toward prostate cancer screening among Chinese men are still poorly understood. The objective of the study was to evaluate attitudes toward prostate cancer screening and their association with prostate cancer screening intention among Chinese men. In this community-based study, 340 males were randomly recruited. Three distinct concepts related to prostate cancer screening attitudes were evaluated, including perceived consequences of screening, moral obligation, and anticipated regret. The intention to have prostate cancer screening was asked. Only 5.00% of the study participants had prostate cancer screening before, while 69.71% have an intention to undergo screening in the future. Participants with a high level of anticipated regret also had a high likelihood to have screening in the future, with an adjusted odds ratio (aOR) of 1.82. Participants who had favorable attitudes toward the consequence of participating in prostate cancer screening had a high likelihood to undergo screening, with an aOR of 1.22. Participants who were more concerned about pain and invasion of privacy were less likely to have an intention to have prostate cancer screening, with aORs of 0.53 and 0.57, respectively. To enhance screening intention, public health programs should include components related to anticipated regrets and perceived consequences.
p53-Induced Autophagy Regulates Chemotherapy and Radiotherapy Resistance in Multidrug Resistance Cancer Cells
Authors: Ma Shumei , Kong Dejuan , Fu Xinxin , Liu Lin , Liu Yi , Xue Chang , Tian Zhujun , Li Lan , Liu Xiaodong
Published: October 2021

Background

Multidrug resistance (MDR), a major problem in oncology therapy, limits the effectiveness of anticancer drugs. Although p53 functions as a tumor suppressor, the associations between p53 status, autophagy, and MDR are complicated and conditional.

Method

 In this report, p53-null human ovarian cancer cell line SKOV3 and its MDR phenotype SKVCR and human leukemia cell line CEM and its MDR phenotype CEM-VLB) (p53 mutant cell line) were used.

Results

 Compared to parental SKOV3, the mRNA and protein levels of MAPLC3-II and Beclin1 were higher in SKVCR cells. The inhibition of autophagy by 3-MA significantly sensitized SKVCR to VCR. Conversely, in drug-resistant leukemic cells CEM-VLB, the expressions of Beclin1 and MAPLC3-II were lower than CEM. CEM and CEM-VLB cells were treated with VLB .01 or 0.5 μg/mL, respectively, and the expression of p53 and autophagy up-regulated after VLB (.01 μg/mL) treatment in CEM cells. The percentage of S-phase and G2/M phase cells up-regulated significantly by .01 μg/mL VLB in CEM, which may relate to the status of p53 of CEM cells. A combination of radiation with 3-MA significantly increased apoptosis in CEM-VLB cells.

Conclusion

 Our discovery found that p53 is an important regulator controlling the balance between autophagy and MDR, as a potential drug target for ovarian cancer and leukemia.
Promoting Recall and Preserving the Historical Authenticity of Data Used to Investigate Food Regulatory Policy in Australia
Authors: Ashton Bronwyn , Star Cassandra , Coveney John
Published: October 2021

This article reports on research methodology used for a case study investigating public health nutrition engagement in food regulatory policy processes in Australia. It aims to explore methods used and outline a model for how researchers can promote participant recall and accuracy. A set of key documents identified as relevant to voluntary food fortification policy (VFP) were analysed using Bacchi’s ‘What’s the problem represented to be?’ approach. The results informed a series of present-day, semi-structured, in-depth telephone interviews with experts in VFP. The major epistemological difficulty was the necessary reliance upon participant memory. Consequently, oral history methods were used to aid key informant recall. Several participants noted a benefit for their recollection of events from the tools employed. The experiences and approaches outlined in this article contribute to the toolkit needed when investigating historical events and may provide a useful model for other nutrition-related policy research.
Documentary Analysis Within a Realist Evaluation: Recommendations From a Study of Sexual Assault Referral Centres
Authors: Price Holly , Domoney Jill , Ariss Steven , Hughes Elizabeth , Trevillion Kylee
Published: October 2021

Realist approaches are increasingly used in studies of complex health interventions/evaluations to understand how programmes work, for whom and under what circumstances. Mixed-method data sources can be used to generate, refine and test realist programme theories, which explore causal links about the contexts that affect the mechanisms of an intervention and lead to the production of different outcomes. The realist approach provides a framework for a detailed understanding of how a programme functions, aiding with the implementation, refinement or adaptation of interventions. Documentary analysis provides an overview of the theoretical and practical functioning of a service and the ways it is structured to provide interventions. Data are often collected early in the evaluation and can include service specifications, organisational policies and procedures and routine audit data. This paper describes a two-stage process of documentary analysis, where data extraction forms and journey maps are used to explore how Sexual Assault Referral Centres (SARCs) in England respond to the mental health and substance use needs of users. Using documentary analysis as part of a sequential data collection process can be valuable in informing subsequent data sources (e.g qualitative interview schedules can be used to further test and refine theories from a documentary analysis). Considerations for researchers in applying documentary analysis include the value of keeping initial searches broad, to capture documents from a range of sources; the need for clarity about the prioritisation of data sources in the selection process; the benefit in establishing a standardised extraction form that incorporates the wider context within which the intervention functions; taking steps to ensure face validity and transferability during interpretation of data sources; the benefits of transforming information from the data extraction form into a visual journey map.
Anti-interleukin 5 therapies failure criteria in severe asthma: a Delphi-consensus study
Authors: Mattei Laura , Suehs Carey M. , Alagha Khuder , Bourdin Arnaud , Brousse Christophe , Charriot Jeremy , Devouassoux Gilles , Fry Stephanie , Guilleminault Laurent , Gouitaa Marion , Taille Camille , Chanez Pascal , Pahus Laurie
Published: October 2021

Background:

Current practices for assessing response to anti-interleukin 5/R treatment in severe asthma patients are heterogeneous. The objective of this study was to achieve an expert consensus defining failure criteria for anti-interleukin 5/R treatment in severe asthma patients.

Methods:

Experts were invited to a 5-round Delphi exercise if they were pulmonologists managing ⩾30 patients at a nationally recognized severe asthma expert centre. Following two rounds of statement-generating brainstorming, the expert panel ranked each statement according to a 5-point Likert-type scale during three additional rounds. Positive consensus was considered achieved when ⩾80% of experts agreed with a statement with >50% strong agreement and <15% disagreement.

Results:

Twenty experts participated in the study. All experts agreed that predefined treatment goals defining effectiveness should be personalized during shared decision making via a patient contract. Treatment failure was defined as (1) absence of a reduction in exacerbation rates by ⩾25% or (2) absence of a reduction in oral corticosteroid therapy by ⩾25% of the initial dosage or (3) occurrence of emergency room visits or hospitalizations after 6 months of treatment. Treatment failure should result in discontinuation. For partial responders, treatment discontinuation was not recommended unless an alternative from another therapeutic class exists and should be discussed in a multidisciplinary consultation.

Conclusion:

The present study provides objective criteria for anti IL5 or IL5R failure in severe asthma and suggests consensus based guidelines for prescription, evaluation and discontinuation decision-making.
Radioimmunotherapy for solid tumors: spotlight on Glypican-1 as a radioimmunotherapy target
Authors: Sabanathan Dhanusha , Lund Maria E. , Campbell Douglas H. , Walsh Bradley J. , Gurney Howard
Published: October 2021

Radioimmunotherapy (i.e., the use of radiolabeled tumor targeting antibodies) is an emerging approach for the diagnosis, therapy, and monitoring of solid tumors. Often using paired agents, each targeting the same tumor molecule, but labelled with an imaging or therapeutic isotope, radioimmunotherapy has achieved promising clinical results in relatively radio-resistant solid tumors such as prostate. Several approaches to optimize therapeutic efficacy, such as dose fractionation and personalized dosimetry, have seen clinical success. The clinical use and optimization of a radioimmunotherapy approach is, in part, influenced by the targeted tumor antigen, several of which have been proposed for different solid tumors. Glypican-1 (GPC-1) is a heparan sulfate proteoglycan that is expressed in a variety of solid tumors, but whose expression is restricted in normal adult tissue. Here, we discuss the preclinical and clinical evidence for the potential of GPC-1 as a radioimmunotherapy target. We describe the current treatment paradigm for several solid tumors expressing GPC-1 and suggest the potential clinical utility of a GPC-1 directed radioimmunotherapy for these tumors.
Jokering Bodies
Authors: Agosto Vonzell , Roberts LaSonja , Migueliz Valcarlos María , Nkrumah Tara , Grosland Tanetha , Bratspis Andrew , Warren Nathalie , Reynolds Edwin
Published: October 2021

This article brings forth the difficulties and possibilities of enacting the role of “Joker” from Boal’s (1979) Joker System—formerly called the poetics of the oppressed. The authors acknowledge jokering as an apprehensive performance of brokering, of bodies that matter and are matter, that can provoke anti-oppressive actions and reinscribe oppressions. As such, four backdrops are engaged to further the methodological, theoretical, and curricular/pedagogical force of jokering as a performance that unsettles the status quo: Latina/Chicana feminist theories used in mentoring, performance-based action research with middle-school students, professional leadership development for schools, and socio-technological analysis with theatre in online/distance education. Each example from our praxis illustrates how the roles of emerging researcher, mentor-researcher, and researcher-practitioner are performed and troubled (jokered) from different disciplinary and theoretical perspectives to foster social justice praxis and outcomes.
The technical non-reproducibility of the Earth system: Scale, Biosphere 2, and T.C. Boyle’s Terranauts
Authors: Hüpkes Philip , Dürbeck Gabriele
Published: October 2021

The Anthropocene concept draws on a technologically mediated macroscale, allegedly all-encompassing perspective on the interconnectedness of planetary, social and cultural systems. It is thus part of a genealogy traceable to systems thinking and cybernetic imaginaries of planetary-scale controllability; but at the same time, it relies on a techno-scientific infrastructure that is part of the accumulation of technical entities which Peter Haff calls “technosphere.” This oscillation between technology as a means of control and as an autonomous system that is inaccessible to sensual experience constitutes a theoretical challenge. Responding to this challenge, we combine Haff’s “technosphere” theory with a focus on the aspect of scale and the environmental character of technology. We discuss the Biosphere 2 experiment and its literary reflection in T.C. Boyle’s novel The Terranauts (2016) as an example of an attempted lower-scale technological reproduction of the Earth system. We show that the experiment suggests that technology has to be conceived as both scale variant (its functions differ across scales) and independent from its scale (as always already constituted by its respective environment).
Lymphocyte subsets as a predictor of severity and prognosis in COVID-19 patients
Authors: Zhang Peng , Du Wei , Yang Ting , Zhao Lei , Xiong Richeng , Li Yongqiang , Geng Yan , Lu Weizhong , Zhou Juan
Published: October 2021

Background

Coronavirus disease 2019 (COVID-19) had become a worldwide health threat. Early prediction of the severity of COVID-19 patients was important for reducing death rate and controlling this disease.

Methods and materials

A total of 301 patients confirmed with COVID-19 in Wuhan from 8 February to 10 April 2020 were included. Clinical data were collected and analyzed. Diagnostic and prognostic utility of blood cell counts and lymphocyte subsets in COVID-19 patients were investigated. The receiver operator characteristic curve (ROC) was used in discriminating the mild and severe/critical cases.

Results

There were difference in blood cell counts and lymphocyte subsets among mild, severe and critical patients, which were also influenced by comorbidities and duration of disease. The area under the ROC of lymphocyte, CD3+ T cells, CD4+ T cells, and CD8+ T cells were 0.718, 0.721, 0.718, and 0.670, which were higher than that of other hematological parameters. The optimal threshold was 1205, 691, 402, and 177 per μl, respectively. Patients with higher counts of lymphocyte, CD3+ T cells, CD4+ T cells, or CD8+ T cells were correlated with shorter length of stay in hospital ( p < 0.05). Multivariable Cox regression analysis showed disease severity, CD3+ T cells counts and time when the nucleic acid turned negative were independent risk factors for in-hospital death of COVID-19 patients ( p < 0.05).

Conclusion

Blood cell counts and lymphocyte subsets correlated with severity of COVID-19.
Effect of Meniscal Treatment on Functional Outcomes 6 Months After Anterior Cruciate Ligament Reconstruction
Authors: Casp Aaron J. , Bodkin Stephan G. , Gwathmey F. Winston , Werner Brian C. , Miller Mark D. , Diduch David R. , Brockmeier Stephen F. , Hart Joseph M.
Published: October 2021

Background:

Meniscal injuries are commonly associated with anterior cruciate ligament (ACL) tears. Treatment of meniscal injuries can impart delayed weightbearing and range of motion restrictions, which can affect the rehabilitation protocol. The effect of meniscal treatment and subsequent restrictions on strength recovery after ACL reconstruction is unclear.

Purpose/Hypothesis:

The purpose of this study was to compare strength, jumping performance, and patient-reported outcomes between patients who underwent isolated ACL reconstruction (ACLR) and those who underwent surgical intervention for meniscal pathology at the time of ACLR. Our hypothesis was that patients who underwent concurrent meniscal repair (MR) would have lower strength recovery owing to postoperative restrictions.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Patients with ACLR were stratified into isolated ACLR, ACLR and meniscectomy (ACLR-MS), or ACLR-MR groups and were compared with healthy controls. The ACLR-MR group was restricted to partial weightbearing and to 90° of knee flexion for the first 6 weeks postoperatively. All participants completed patient-reported outcomes (International Knee Documentation Committee [IKDC] and Knee injury and Osteoarthritis Outcome Score [KOOS]) and underwent bilateral isokinetic and isometric strength tests of the knee extensor and flexor groups as part of a return-to-sports test battery at 5 to 7 months postoperatively.

Results:

A total of 165 patients with ACLR (50 with isolated ACLR, 44 with ACLR-MS, and 71 with ACLR-MR) and 140 healthy controls were included in the study. Follow-up occurred at a mean of 5.96 ± 0.47 months postoperatively. The control group demonstrated higher subjective knee function, unilateral peak extensor torque, and limb symmetry than did the ACLR-MS and ACLR-MR groups combined ( P < .001 for all). There were no differences in IKDC, KOOS subscales, or unilateral or limb symmetry measures of peak knee extensor or flexor torque among the isolated ACLR, ACLR-MS, and ACLR-MR groups.

Conclusion:

Persistent weakness, asymmetry, and reduced subjective outcome scores at 6-month follow-up after ACLR were not influenced by meniscal treatment. These findings suggested that the weightbearing and range of motion restrictions associated with meniscal repair recovery do not result in loss of early strength or worse patient-reported outcomes.
Concussion Incidence and Recovery Among Youth Athletes With ADHD Taking Stimulant-Based Therapy
Authors: Ali Muhammad , Dreher Nickolas , Hannah Theodore , Li Adam , Asghar Nek , Spiera Zachary , Marayati Naoum Fares , Durbin John , Gometz Alex , Lovell Mark , Choudhri Tanvir
Published: October 2021

Background:

Attention deficit hyperactivity disorder (ADHD) may affect concussion risk and recovery in youth athletes.

Purpose:

To evaluate the association between incidence of concussion and postinjury recovery of symptoms and neurocognitive dysfunction among youth athletes with ADHD and differential stimulant use.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

From 2009 to 2019, the authors administered the Immediate Post-concussion Assessment and Cognitive Testing (ImPACT) to youth athletes at the beginning of each season. Throughout the season, athletes with concussions were examined and readministered the ImPACT both postinjury and again 7 days after the postinjury administration. These athletes (N = 7453) were divided into those with ADHD on stimulant-based therapy (ADHD+meds; n = 167), those with ADHD not on stimulant-based therapy (ADHD-only; n = 354), and those with no ADHD (non-ADHD; n = 6932). Recovery of neurocognitive dysfunction at postinjury and follow-up was calculated using the ImPACT symptom score, verbal memory, visual memory, visual motor skills, and reaction time (calculated as standardized deviations from baseline). Univariate results were confirmed with multivariate analysis.

Results:

The ADHD+meds cohort had a lower incidence of concussion (37.3 concussions per 100 patient-years) compared with the ADHD-only group (57.0 concussions per 100 patient-years) (odds ratio [OR], 0.51 [95% CI, 0.37-0.71]; P < .0001) and non-ADHD group (52.8 concussions per 100 patient-years) (OR, 0.50 [95% CI, 0.37-0.67]; P < .0001). At postinjury, ImPACT scores were elevated from baseline to a similar extent in the ADHD+meds cohort compared with the other 2 groups. By follow-up, however, deviations from baseline were lower among the ADHD+meds group compared with the non-ADHD group in verbal memory (OR, 0.46 [95% CI, 0.28-0.76]; P = .002), visual memory (OR, 0.27 [95% CI, 0.10-0.66]; P = .005), and visual motor skills (OR, 0.58 [95% CI, 0.33-0.99]; P = .048). The deviation at follow-up was also lower among the ADHD+meds group compared with the ADHD-only group in visual memory (OR, 0.56 [95% CI, 0.33-0.96]; P = .04) and visual motor skills (OR, 0.42 [95% CI, 0.22-0.81]; P = .01).

Conclusion:

Stimulant use among youth athletes with ADHD was independently associated with reduced incidence for concussion and lower deviation from baseline in verbal memory, visual memory, and visual motor skills at 7 days postconcussion, suggesting lower neurocognitive impairment at follow-up in this group versus their peers.
The Role of Symmetrical Internal Communication in Improving Employee Experiences and Organizational Identification During COVID-19 Pandemic-Induced Organizational Change
Authors: Sun Ruoyu , Li Jo-Yun Queenie , Lee Yeunjae , Tao Weiting
Published: October 2021

Integrating strategic internal communication research with organizational change literature and organizational support theory, this study proposes a theoretical model to understand the influence of symmetrical internal communication on employees’ cognitive and affective experiences and organizational identification in a COVID-19 pandemic-induced change situation. A quantitative online survey was conducted with 490 full-time employees in the United States in mid-April 2020. Results indicate that symmetrical internal communication during organizational change contributes to employees’ perceptions of change communication quality. In addition, symmetrical internal communication, along with perceived quality of change communication, enhances employees’ perceptions of organizational support and positive emotions during organizational change, which in turn leads to stronger organizational identification. Theoretical and practical implications of the findings are discussed.
Predictors of Anxiety, Stress, and Concern of COVID-19 Infection in Older Adults During the First and the Second Waves of the COVID-19 Pandemic in Slovakia
Authors: Köverová Miroslava , Ráczová Beáta , Kováčová Holevová Bibiána
Published: October 2021

Objectives: This cross-sectional online study examined the role of socio-demographic and psychological characteristics in predicting anxiety, stress, and concern of coronavirus (COVID-19) infection in older adults during the first and second waves of the COVID-19 pandemic in Slovakia. Methods: Six hundred and seven older adults (Sample 1) and 156 older adults (Sample 2) participated in the study during the first and second waves of the COVID-19 pandemic, respectively. The older adults completed a battery of validated instruments for anxiety, stress, concern of COVID-19 infection (outcome variables), satisfaction with health, perceived danger of COVID-19, loneliness, intolerance of uncertainty (IU), optimism, powerlessness, and coping self-efficacy (predictor variables). The data were analyzed using multiple linear regression. Results: The older adults in both samples experienced moderate levels of anxiety, stress, and concern of COVID-19 infection. The greatest amount of variability in anxiety and stress was explained by powerlessness, IU, optimism, and coping self-efficacy. Concern of COVID-19 infection was best predicted by the perceived danger of COVID-19. Conclusion: The findings contribute to the existing knowledge about the mental health of older adults during the COVID-19 pandemic and highlight the role of the psychological predictors of anxiety, stress, and concern of COVID-19 infection during both waves.
Dental Erosion: Effect of Diet Drink Consumption on Permanent Dentition
Authors: Samman M. , Kaye E. , Cabral H. , Scott T. , Sohn W.
Published: October 2021

Objective:

The aim of this study is to examine the effect of diet drinks on dental erosion among a representative sample of US adults.

Methods:

Adult dietary and dental data were analyzed from the 2003–2004 cycle of the National Health and Nutrition Examination Survey. Erosion was measured with a modified tooth wear index and was analyzed as a dichotomous variable. Cluster analysis was performed, and the cluster number was based on having a separate diet drink cluster and the R2 values. Survey procedure and sample weights were used.

Results:

Most of the population (80%) had some form of dental erosive lesions. When compared with the total sample, people with erosion were more likely to be male (52.5%) and older. People with no erosive lesions were younger (42.3%) and non-Hispanic Black (21.2%). Cluster analysis resulted in 4 distinct clusters: high water, high diet drinks, high coffee/tea, and high soda. The respective percentage of individuals in each cluster who had erosion was 78.9%, 85%, 83.9%, and 76.2%, where the “high diet drinks” cluster showed the highest erosion ( P = 0.28). Logistic regression modeling showed that the “high diet drinks” cluster had increased odds of erosion (odds ratio = 1.27; 95% CI = 0.58 to 2.77) when compared with the “high water” cluster, but the relationship was not statistically significant.

Conclusion:

High diet drinks consumption slightly increased the odds of dental erosion among US adults, although this relationship was not statistically significant. It is thus not yet clear that dentists should recommend diet drinks, as they might be linked to systemic diseases. Further research is needed to explore more about risk factors of erosion.

Knowledge Transfer Statement:

The findings of this study are suggestive, though not significantly, that diet drinks may increase risk for dental erosion. While further research is needed, it is not clear that dentists should recommend these drinks as healthy substitutes for sugary drinks.
Prevalence of fatigue after stroke: A systematic review and meta-analysis
Authors: Alghamdi Ibraheem , Ariti Cono , Williams Adam , Wood Emma , Hewitt Jonathan
Published: October 2021

Background and Purpose

Post-stroke fatigue is a debilitating and long-lasting condition. However, there are uncertainties regarding its prevalence and variability between studies. This review aims to estimate the prevalence of fatigue and determine the factors responsible for its variation in the literature.

Methods

A systematic review was conducted for all published studies (search to November 2020) using AMED, CINAHL, EMBASE, MEDLINE, PsycINFO, SCOPUS and Web of Science. Papers were included if they recruited participants with stroke, used a validated scale to measure fatigue and were in English. Two reviewers screened and assessed the relevant studies for eligibility ( n = 96). The included papers were appraised using the Joanna Briggs Institute (JBI) tool for prevalence studies, and data were extracted by one reviewer. To understand the variation in PSF prevalence between papers, data were pooled and analysed based on relevant methodological (e.g. time of assessment) or clinical factors (e.g. depression) using Review Manager 5.4 software.

Results

While 48 studies were included and summarised ( N = 9004), only 35 were appropriate for the meta-analysis ( N = 6851). The most frequently used tool to measure fatigue was the Fatigue Severity Scale (FSS) ( n = 31). The prevalence was calculated with a cut-off point of four or more using FSS and resulted in an estimate of 48% (95% CI 42–53%). Time of assessment (<6 vs ≥6 months), stroke type (ischaemic vs haemorrhagic/subarachnoid haemorrhage) and geographical location (East Asia vs Europe) could explain the prevalence variation between studies.

Conclusions

Fatigue is prevalent among stroke survivors. This condition varies in terms of occurrence between studies; however, time of assessment, stroke type and geographical location might explain this variation. As this review estimates the overall burden of fatigue after stroke, it provides a useful indicator to inform policy, planning and healthcare professionals. Further efforts are required to investigate the mechanisms that lead to PSF, particularly in the groups that show high prevalence, in order to prevent or alleviate it.
Seismic risk assessments for real estate portfolios: Impact of engineering investigation on quality of seismic risk studies
Authors: Lee Yajie , Graf William P , Thiel Charles C , Hu Zhenghui , Ellis Mark
Published: October 2021

Seismic risk evaluation studies for real estate portfolios conducted by technical professionals (often Civil and Structural Engineers) have become increasingly desirable and common in financial decisions. In this article, we develop a series of risk measures and ratings based on common outcomes from probabilistic portfolio seismic risk assessments. We first define two portfolio risk metrics: Portfolio Expected Loss (PELα) and Portfolio Upper Loss (PULα), where “α” is the annual exceedance probability, or the corresponding return period (“1/α”). PULα/PELα ratio characterizes the uncertainty in estimated portfolio risks which results from the uncertainty in seismic performance of the individual assets. Three uncertainty levels are defined, namely, low, medium, and high, based on the PULα/PELα. We then develop an asset risk metric, called Tail Contribution Index (TCIα), that characterizes the contribution of individual assets to the portfolio losses that fall within the high-consequence “tail” of the portfolio loss distribution. To describe the overall engineering efforts of a portfolio seismic risk study, we develop a portfolio risk metric, called Portfolio Level of Investigation (PLIα), that characterizes the effective level of engineering investigation. Three investigation levels are defined: low ( desktop), medium ( semi-engineered), and high ( engineered), based on the PLIα. Finally, based on the combination of uncertainty level and investigation level, we develop a rating scheme by which the quality (Qα) of a portfolio seismic risk study is characterized. Five quality levels are defined: very poor, poor, fair, good, and very good. These risk indices and ratings can help stakeholders and technical professionals better diagnose and communicate portfolio seismic risks, scope adequate studies, effectively utilize valuable resources, and base financial decisions on risk assessment results that have the desired reliability.
Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
Authors: Stratmann Svea , Yones Sara A. , Garbulowski Mateusz , Sun Jitong , Skaftason Aron , Mayrhofer Markus , Norgren Nina , Herlin Morten Krogh , Sundström Christer , Eriksson Anna , Höglund Martin , Palle Josefine , Abrahamsson Jonas , Jahnukainen Kirsi , Munthe-Kaas Monica Cheng , Zeller Bernward , Tamm Katja Pokrovskaja , Cavelier Lucia , Komorowski Jan , Holmfeldt Linda
Published: October 2021

Numerous studies have been performed over the last decade to exploit the complexity of genomic and transcriptomic lesions driving the initiation of acute myeloid leukemia (AML). These studies have helped improve risk classification and treatment options. Detailed molecular characterization of longitudinal AML samples is sparse, however; meanwhile, relapse and therapy resistance represent the main challenges in AML care. To this end, we performed transcriptome-wide RNA sequencing of longitudinal diagnosis, relapse, and/or primary resistant samples from 47 adult and 23 pediatric AML patients with known mutational background. Gene expression analysis revealed the association of short event-free survival with overexpression of GLI2 and IL1R1, as well as downregulation of ST18. Moreover, CR1 downregulation and DPEP1 upregulation were associated with AML relapse both in adults and children. Finally, machine learning–based and network-based analysis identified overexpressed CD6 and downregulated INSR as highly copredictive genes depicting important relapse-associated characteristics among adult patients with AML. Our findings highlight the importance of a tumor-promoting inflammatory environment in leukemia progression, as indicated by several of the herein identified differentially expressed genes. Together, this knowledge provides the foundation for novel personalized drug targets and has the potential to maximize the benefit of current treatments to improve cure rates in AML.
Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active
Authors: Garcia Jacqueline S. , Kim Haesook T. , Murdock H. Moses , Cutler Corey S. , Brock Jennifer , Gooptu Mahasweta , Ho Vincent T. , Koreth John , Nikiforow Sarah , Romee Rizwan , Shapiro Roman , Loschi Fiona , Ryan Jeremy , Fell Geoffrey , Karp Hannah Q. , Lucas Fabienne , Kim Annette S. , Potter Danielle , Mashaka Thelma , Stone Richard M. , DeAngelo Daniel J. , Letai Anthony , Lindsley R. Coleman , Soiffer Robert J. , Antin Joseph H.
Published: October 2021

Adding the selective BCL-2 inhibitor venetoclax to reduced-intensity conditioning chemotherapy (fludarabine and busulfan [FluBu2]) may enhance antileukemic cytotoxicity and thereby reduce the risk of posttransplant relapse. This phase 1 study investigated the recommended phase 2 dose (RP2D) of venetoclax, a BCL-2 selective inhibitor, when added to FluBu2 in adult patients with high-risk acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and MDS/myeloproliferative neoplasms (MPN) undergoing transplant. Patients received dose-escalated venetoclax (200-400 mg daily starting day −8 for 6-7 doses) in combination with fludarabine 30 mg/m2 per day for 4 doses and busulfan 0.8 mg/kg twice daily for 8 doses on day −5 to day −2 (FluBu2). Transplant related–toxicity was evaluated from the first venetoclax dose on day −8 to day 28. Twenty-two patients were treated. At study entry, 5 patients with MDS and MDS/MPN had 5% to 10% marrow blasts, and 18 (82%) of 22 had a persistent detectable mutation. Grade 3 adverse events included mucositis, diarrhea, and liver transaminitis (n = 3 each). Neutrophil/platelet recovery and acute/chronic graft-versus-host-disease rates were similar to those of standard FluBu2. No dose-limiting toxicities were observed. The RP2D of venetoclax was 400 mg daily for 7 doses. With a median follow-up of 14.7 months (range, 8.6-24.8 months), median overall survival was not reached, and progression-free survival was 12.2 months (95% confidence interval, 6.0-not estimable). In patients with high-risk AML, MDS, and MDS/MPN, adding venetoclax to FluBu2 was feasible and safe. To further address relapse risk, assessment of maintenance therapy after venetoclax plus FluBu2 transplant is ongoing. This study was registered at clinicaltrials.gov as #NCT03613532.
Inflammatory complications of CGRP monoclonal antibodies: a case series
Authors: Ray Jason C. , Allen Penelope , Bacsi Ann , Bosco Julian J. , Chen Luke , Eller Michael , Kua Hock , Lim Lyndell L. , Matharu Manjit S. , Monif Mastura , Ruttledge Martin , Stark Richard J. , Hutton Elspeth J.
Published: October 2021

Background

Calcitonin gene-related peptide (CGRP) is expressed throughout the body and is a known mediator of migraine, exerting this biological effect through activation of trigeminovascular, meningeal and associated neuronal pathways located in close proximity to the central nervous system. Monoclonal antibodies (mAb) targeting the CGRP pathway are an effective new preventive treatment for migraine, with a generally favourable adverse event profile. Pre-clinical evidence supports an anti-inflammatory/immunoregulatory role for CGRP in other organ systems, and therefore inhibition of the normal action of this peptide may promote a pro-inflammatory response.

Cases

We present a case series of eight patients with new or significantly worsened inflammatory pathology in close temporal association with the commencement of CGRP mAb therapy.

Conclusion

This case series provides novel insights on the potential molecular mechanisms and side-effects of CGRP antagonism in migraine and supports clinical vigilance in patient care going forward.
A novel formulation of theranostic nanomedicine for targeting drug delivery to gastrointestinal tract cancer
Authors: Lodhi Madeeha Shahzad , Khan Muhammad Tahir , Aftab Saira , Samra Zahoor Qadir , Wang Heng , Wei Dong Qing
Published: October 2021

Background

Theranostic nanomedicines contain a nanovehicle that has fluorescent properties and can be used for diagnostic, therapeutic and prognostic purposes. The transferrin receptor expression is 1000-fold higher in rapidly growing cancer cells as compared to the normal cells and, therefore, can be used in targeted drug delivery systems. The objective of the present study was to design a novel targeted gold nanoparticle (GNPs)-based theranostic formulation for gastrointestinal (GI) tract-related cancers. The synthesized GNPs were conjugated to transferrin and doxorubicin both separately and collectively to check their cytotoxic properties. The in vitro cytotoxicity of nanocomposites was observed against colon cancer cell line HCT-116. The doxorubicin conjugated nanocomposites showed almost the same cytotoxicity, but more effect at later hours (h). The IC50 and IC100 were 50 µg/ml and 250 µg/ml, respectively, equivalent to the doxorubicin weight for GNP theranostic nanomedicine.

Results

The maximum effect was observed after 12 h and nanomedicines were still active after 72 h of treatment. Our in vivo data proved that nanomedicine crossed all the barriers and was successfully delivered to the tumour cells. Theranostic nanomedicine’s (TNM) effect on body weight and survival rate on mice was many folds better than mice in pure doxorubicin group. It also showed almost 80% survival rate on day 40. The in vivo and in vitro results show the effects of prolonged drug release and the nanomedicine was not toxic to vital organs of the animal.

Conclusion

This is one of its kind studies in which a novel targeted nanomedicines approach was formulated for therapeutic as well as prognostic purposes against GI tract cancer.

Graphic Abstract