bluuebunny/crossref_metadata_2025 huggingface dataset:
Multilevel effective material approximation for modeling ellipsometric measurements on complex porous thin films
Authors: Sachse René , Hodoroaba Vasile-Dan , Kraehnert Ralph , Hertwig Andreas
Published: June 2022

Catalysts are important components in chemical processes because they lower the activation energy and thus determine the rate, efficiency and selectivity of a chemical reaction. This property plays an important role in many of today’s processes, including the electrochemical splitting of water. Due to the continuous development of catalyst materials, they are becoming more complex, which makes a reliable evaluation of physicochemical properties challenging even for modern analytical measurement techniques and industrial manufacturing. We present a fast, vacuum-free and non-destructive analytical approach using multi-sample spectroscopic ellipsometry to determine relevant material parameters such as film thickness, porosity and composition of mesoporous IrOx–TiOy films. Mesoporous IrOx–TiOy films were deposited on Si wafers by sol–gel synthesis, varying the composition of the mixed oxide films between 0 and 100 wt%Ir. The ellipsometric modeling is based on an anisotropic Bruggeman effective medium approximation (a-BEMA) to determine the film thickness and volume fraction of the material and pores. The volume fraction of the material was again modeled using a Bruggeman EMA to determine the chemical composition of the materials. The ellipsometric fitting results were compared with complementary methods, such as scanning electron microscopy (SEM), electron probe microanalysis (EPMA) as well as environmental ellipsometric porosimetry (EEP).
Consolidating EFL content and vocabulary learning via interactive reading
Authors: Wu Shiyu , Liu Dilin , Li Zan
Published: June 2022

Via a 90-min classroom experiment, this study examined the effects of interactive reading on EFL students’ content and vocabulary learning. Specifically, two intact Chinese college EFL classes with the same level of English proficiency participated in this study. One was taught with a “read plus intra/inter-group discussion” (Read-Discuss) approach and the other was instructed with a traditional approach involving no student-student interaction. After the experiment, the students took two immediate posttests (one on content and one on vocabulary) and, three weeks later, retook the same tests (delayed posttests). The results of statistical analyses indicate that whereas in the immediate posttests both classes attained a similar level of learning on both the content and vocabulary tests, in the delayed posttests, the Read-Discuss class significantly outperformed the traditional class, demonstrating that the Read-Discuss approach produced significantly better consolidated learning/retention in both content and vocabulary. Pedagogical/research implications of the results are also discussed.
Considering best practices in color palettes for molecular visualizations
Authors: Garrison Laura , Bruckner Stefan
Published: June 2022

Biomedical illustration and visualization techniques provide a window into complex molecular worlds that are difficult to capture through experimental means alone. Biomedical illustrators frequently employ color to help tell a molecular story, e.g., to identify key molecules in a signaling pathway. Currently, color use for molecules is largely arbitrary and often chosen based on the client, cultural factors, or personal taste. The study of molecular dynamics is relatively young, and some stakeholders argue that color use guidelines would throttle the growth of the field. Instead, content authors have ample creative freedom to choose an aesthetic that, e.g., supports the story they want to tell. However, such creative freedom comes at a price. The color design process is challenging, particularly for those without a background in color theory. The result is a semantically inconsistent color space that reduces the interpretability and effectiveness of molecular visualizations as a whole. Our contribution in this paper is threefold. We first discuss some of the factors that contribute to this array of color palettes. Second, we provide a brief sampling of color palettes used in both industry and research sectors. Lastly, we suggest considerations for developing best practices around color palettes applied to molecular visualization.
A GA-BP neural network for nonlinear time-series forecasting and its application in cigarette sales forecast
Authors: Sun Zheng , Li XiNa , Zhang HongTao , Ikbal Mohammad Asif , Farooqi Ataur Rahman
Published: June 2022

Neural network modeling for nonlinear time series predicts modeling speed and computational complexity. An improved method for dynamic modeling and prediction of neural networks is proposed. Simulations of the nonlinear time series are performed, and the idea and theory of optimizing the initial weights and threshold of the GA algorithm are discussed in detail. It has been proved that the use of GA-BP neural network in cigarette sales forecast is 80% higher than before, and this method has higher accuracy and accuracy than the gray system method.
Meta-analysis of responses of broiler chickens to Bacillus supplementation: Intestinal histomorphometry and blood immunoglobulin
Authors: Ogbuewu Ifeanyi Princewill , Mbajiorgu Christian Anayo
Published: June 2022

The broiler chicken industry needs effective probiotics to boost productivity and health. However, published data on the impact of in-feed Bacillus supplementation on physiological parameters in healthy broiler chickens are often conflicting and inconclusive. As a result, this meta-analysis aimed to assess the influence of Bacillus on intestinal histomorphometry (villus height [VH], crypt depth [CD], and VH:CD) and blood immunoglobulin (A, G, and M) levels in healthy broiler chickens. Results were pooled using a random-effects model and presented as Hedges d (d) at 95% confidence intervals (CIs). The results indicate that Bacillus improves gut histomorphometric variables in broilers with the exception of duodenal and ileal CD, which had comparable values with the controls. Likewise, broiler chickens fed Bacillus had increased blood immunoglobulin (Ig) levels compared to controls (IgA: d = 2.29 mg/mL, 95% CI: 1.54–3.04; IgG: d = 2.17 mg/mL, 95% CI: 1.36–2.98; IgM: d = 1.00 mg/mL, 95% CI: 0.54–1.46) taking cognizance of heterogeneity (I
2 = 96–98%). Subgroup analysis showed that studied moderators (Bacillus species, broiler strain, and dosage and duration of supplementation) influenced the results of the meta-analysis. In conclusion, our results suggested that the inclusion of Bacillus at 0.1–6.0 × 106 colony-forming unit/g in broiler chicken feed enhanced the absorptive capacity of the small intestine and blood immunoglobulin levels of broiler chickens. The findings of this study avail important suggestions on policy advancements and sustainable usage of Bacillus in broiler chicken industry.
Abundant optical soliton structures to the Fokas system arising in monomode optical fibers
Authors: Zhang Pei-Ling , Wang Kang-Jia
Published: June 2022

Three effective methods, namely, the simplified extended tanh-function method (SETFM), variational method (VM) and He’s frequency formulation method (HFFM) are employed to investigate the Fokas system that arises in the monomode optical fibers. Fifteen sets of the soliton solutions such as the bright soliton, dark soliton, bright-dark soliton, double-dark soliton, double-bright soliton, triple-bright soliton, kinky periodic soliton and perfect periodic soliton solutions are developed. The dynamic performances of the different soliton solutions are plotted via the 3-D contours and 2-D curves to interpret the physical behaviors by assigning reasonable parameters. From the results obtained from this study, it is found that three proposed methods are promising ways to seek various soliton solutions of the PDEs in optical physics.
Evaluation of ESBL resistance dynamics inEscherichia coliisolates by mathematical modeling
Authors: Hurdoganoglu Ulas , Kaymakamzade Bilgen , Sultanoglu Nazife , Guler Emrah , Hincal Evren , Suer Kaya
Published: June 2022

Antibiotic resistance is becoming one of the threats to global health. This crisis has been attributed to the over-the-counter and overuse of antibiotics leading bacteria to gain the ability to resist and survive even in the presence of antimicrobial agents.Escherichia coli(E. coli) is one of the major gram-negative bacteria that are the representative indicators of antibiotic resistance. One of the mechanisms of gaining antibiotic resistance is the ability ofE. colito gain the production of extended-spectrum beta-lactamases (ESBL). In this study, Near East University Hospital data from 2016 to 2019 were used to study the dynamics of ESBL-producing (ESBL+{\text{ESBL}}^{+}) and non-ESBL-producing (ESBL−{\text{ESBL}}^{-})E. coliinfections by using a mathematical model. In our study, the aim was to evaluate the distribution of infections caused by resistantE. colistrains in later years and to increase the success of treatment in patients infected withE. coliby reducing the problem of antibiotic resistance. By using the mathematical model and data of the patients, basic reproduction number (R0) values were calculated to study epidemiologic dynamics of the disease. TheR0E−{R}_{0}^{{E}^{-}}andR0E+{R}_{0}^{{E}^{+}}values forESBL−{\text{ESBL}}^{-}and ESBL+ {\text{ ESBL}}^{+}\text{ }E. coliinfections were calculated, respectively. According to the model and the data used within the study, it was calculated thatR0E−{R}_{0}^{{E}^{-}}to be 1,266,403 andR0E+{R}_{0}^{{E}^{+}}to be 2,096,747. Since the values forR0E−{R}_{0}^{{E}^{-}}andR0E+{R}_{0}^{{E}^{+}}were equal or greater than 1, this suggests that currently theESBL−\hspace{.25em}{\text{ESBL}}^{-}and ESBL+ {\text{ ESBL}}^{+}\text{ }E. coliinfections are in epidemic character for Cyprus. Furthermore, when simulation analyses were carried out for the model, it was predicted that in 2042 theESBL−{\text{ESBL}}^{-}and ESBL+{\text{ ESBL}}^{+}E. coliinfection trends will equalize. After 2042, theESBL− {\text{ESBL}}^{-}\text{ }E. coliinfections will indicate a descending pattern whereas ESBL+ {\text{ ESBL}}^{+}\text{ }E. coliinfection will increase constantly.
Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storage
Authors: Trambloy Quentin , Vigneron Jean , Clarot Igor , Blaise Franck , D’Huart Elise , Demoré Béatrice
Published: June 2022

Objectives

Azacitidine is a pyrimidine nucleoside analogue whose stability is temperature dependent. Numerous publications have studied the stability of this drug with discordant results. The purpose of this work is to study the stability of azacitidine suspensions under different conditions to allow preparation in advance: vials stored at room temperature or between 2 and 8 °C, reconstituted with refrigerated water for injection (WFI) or frozen/thawed WFI, azacitidine suspensions stored at room temperature, 2–8 °C or at −20 °C. The feasibility of a vented ChemoClave® Spike vial was also tested to reconstitute and collect azacitidine to aid the preparation stage.

Methods

The stability study was performed by HPLC coupled to a photodiode array detector. The method was validated according to ICH Q2(R1). Two syringes were prepared for each analysis condition and two samples were realised for each syringe at each time of the analysis. For a storage at 2–8 °C, analyses were performed for up to 168 h. The stability was studied after 2 h at room temperature. For frozen storage, the stability was studied after 28 days.

Results

Azacitidine 25 mg/mL suspensions stored between 2 and 8 °C, prepared with refrigerated WFI or frozen/thawed WFI, retained more than 90% of the initial concentration for 96 h and then for 2 h at room temperature. Prepared with frozen/thawed WFI, azacitidine 25 mg/mL suspensions stored at −20 °C for 28 days and then 72 h between 2 and 8 °C after thawing, retained more than 90% of the initial concentration. When using a Spike system compared to using a needle for reconstitution and collection of the suspension, the results obtained by HPLC showed a decrease of 1.47% in the concentration of azacitidine. The comparisons of the volumes withdrawn after reconstitution were similar when using a Spike system or a needle.

Conclusions

Azacitidine 25 mg/mL suspensions reconstituted with refrigerated WFI were chemically stable for 4 days when stored at 2–8 °C whatever the storage of vials (refrigerator or room temperature), and 2 h at room temperature. A storage of azacitidine 25 mg/mL suspensions in syringes prepared with frozen/thawed WFI at −20 °C has been validated for up to 28 days, leading to the possibility to prepare in advance. A Spike device can be used to reconstitute and collect azacitidine.
Impact of bone marrow allotransplantation on functional state of mast cells
in lymph nodes
Authors: Romanov Vitaly O. , Vorobyova Olga V. , Romanova Lyubov P.
Published: June 2022

Objective: to analyze the functional state of mast cells (MC) after bone marrow allotransplantation at the early stages of the experiment.
Materials and Methods. The experiments were carried out on 40 outbred male mice, which were divided into 3 groups: Group 1 with intact animals (n=10); Group 2 with control animals injected with 0.85% sodium chloride solution (n=10); Group 3 with experimental animals (n=30) injected into their tail vein with a cell suspension from another mouse under ether anesthesia. The state of mast cells was evaluated by the method of staining with polychrome toluidine blue sensu P.G. Unna.
Results. Forty minutes after the introduction of foreign bone marrow in the medulla, metachromatic MC were found near the vessels, and their proportion (60%) prevailed over orthochromatic MC (40%). MC were most often located in groups, especially near the vessels, in contact with each other. The morphometric parameters of MC were changing (diameter, 8.00-17.00 μm 6.00-12.00 μm vs in intact MC). Two hours after the experiment, in accordance with the degree of heparin sulfation, metachromatic mast cells were predominantly detected (92%), and extensively degranulated MC predominated (61%), p<0.05. The size of MC was changing (diameter: 3.00-9.00 μm; distance between cells: 29.00-53.00 μm). One-way analysis of variance established that there was a significant effect of the experiment duration on the change in the proportion of MC with metachromatic staining.
Conclusion. An introduction of bone marrow transplant significantly changes the functional profile of mast cells.
Le parlement marocain et la nature du système politique dix ans après la réforme constitutionnelle de 2011
Authors: Brouksy Omar
Published: June 2022

L’instabilité constitutionnelle au Maroc traduit de véritables enjeux de pouvoir. Au cœur de cette dynamique, le parlement est une des institutions qui a connu le plus de changements tant au niveau de sa structure que ses attributions. La dernière réforme constitutionnelle de 2011 n’a pas dérogé à la règle. Dans cet article, nous présenterons les avancées et les limites que révèlent l’exercice du pouvoir monarchique, gouvernemental et parlementaire au cours des dix dernières années. Il s’agira de vérifier si la nature du régime tend à limiter l’ampleur de cette dynamique eu égard à la prééminence du Roi et aux pouvoirs du gouvernement, limités certes mais variables.
Morphological evaluation of biocompatibility of a propylene-based fluoroplastic prosthesis during hernioplasty
Authors: IS Tsydzik , UA Ivantsou , AU Ivantsou
Published: June 2022

The presented article gives an experimental substantiation of the use of a mesh endoprosthesis consisting of polypropylene mesh and polytetrafluoroethylene, the reaction of the surrounding tissues around the prosthesis at different stages of wound healing is shown.
Broken prosthetic distal inter-locking modular femur stem: a case report of rare implant type failure
Authors: Lekhi Akshay , Patel Kuntal , Herlekar Deepak
Published: June 2022

A 79-year old female presented with broken REEFTM stem (Depuy) femur prosthesis. She had three hip surgeries for trauma, followed by primary hip replacement (15 years before presenting) and later fifth surgery (seven years before presenting) for periprosthetic subtrochanteric femur fracture with a Depuy REEFTM stem system. The non-union at left femur subtrochanteric region fracture landed in this implant failure. The complex medical comorbidities and multiple hip surgeries made this a high-risk scenario. Patient recuperated satisfactorily but passed away 2 years post-operatively with urosepsis. Conclusion is tha no prosthetic stem can be completely immune to failure.
Increasing Pediatric Morning Report Educational Value Through Quality Improvement
Authors: Zuckerman Anna , Robinson Keith J. , Twichell Sarah A. , Bonenfant Nicholas , Naud Shelly , Runte K. Elisabeth , Couser Sarah , First Lewis R. , Flyer Jonathan N.
Published: June 2022

BACKGROUND

Morning report (MR) is a common case-based conference in graduate medical education. Recent studies highlight participant dissatisfaction with the educational value of MR, but data are lacking on means for improvement. We aimed to increase MR quality and participant satisfaction at our academic pediatric residency program.

METHODS

Improvement science was used to develop and implement a new standardized pediatric MR process (intervention), with 5 core educational elements and structured resident–faculty mentorship. Educational elements were measured via feedback forms and tracked using a run chart. Residents and faculty were surveyed regarding MR quality and satisfaction at baseline and 6 months postintervention; responses were analyzed using mixed effects logistic regression.

RESULTS

The median of educational elements increased from 3 to 5 (5 maximum) during the 6-month study period and 12-months poststudy. Baseline and postintervention survey response rates were 90% (18 of 20) for residents and 66% (51 of 77) for faculty. Residents reporting high quality MR changed from 50% to 72% (P = .20), and faculty from 29% to 85% (P <.001). Satisfaction with MR content increased for both residents (50%–89%, P = .03) and faculty (25%–67%, P <.001). Resident satisfaction with faculty mentorship before MR increased from 28% to 78% (P = .01); satisfaction with faculty feedback after MR increased from 11% to 56% (P = .02).

CONCLUSIONS

Improvement science can be used to develop a new pediatric graduate medical education process. Requiring core educational elements and providing structured mentorship were associated with improvements in pediatric MR quality and participant satisfaction.
Land-use, abuse, and institutional attempts for correcting human-nature relationships: Europe vs The Americas
Authors: Garrido-Pérez Edgardo I. , Tella-Ruiz David , Sidali Katia Laura , Lincango-Vega Juan G. , Vélez-Sabando Luisa M. , Andrade-Alcívar Luis D.
Published: June 2022

Warnings regarding pollution, soil-fertility losses, mass extinction, Climate Change, and their effects on humans are widely known since at least 1970, still land-abuse pervasively remains. We aimed to contribute to understand why in order to explore how to reduce land-abuse. We critically compared the history, habitats, and land-uses of the Americas with both Alpine and Lowland Europe focusing on the causes and consequences of land-abuse. We chronologically analyzed the development of the recent European efforts for re-appraising ancestral, more sustainable land-uses (AD 1938-2018). Millionaire profits have fixed a dominant culture of subordination of nature and people to a role of mere commodity-producers in the Americas, making difficult for environmentalism to penetrate into decision-making and institutions. Low-scale, sustainable agriculture remains traditionally practiced by Neotropical and Alpine indigenous peoples, but became increasingly abandoned by lowland Europeans and Americas’ landlords since the first Industrial Revolution. The most effective European efforts for conserving the environment emerged and developed as a sort of interplay with the teaching of Ecology and Conservation in universities that trained prospects of both political activists and decision makers. A result is the preeminently scholarly-made, top-down impulse to sustainable land-use in West Europe. Instead, the most effective environmentalists of the Americas’ are not biologists but grassrooted movements culturally influenced or directly led by indigenous peoples. Nowadays, Europe provides finnancial and economic support to the traditional agriculture of its indigenous farmers. Europe-emulators of the Americas should seek to outbalance land-abuse by supporting and learning from the land-uses of Americas’ indigenous farmers too.
Compensatory epidemic of RSV infections during the COVID-19 pandemic. An analysis of infections in children hospitalised in the Department of Paediatrics, Paediatric Nephrology and Allergology of the Military Medical Institute in Warsaw in 2020–2021
Authors:   Department of Paediatrics, Nephrology and Child Allergology, Military Institute of Medicine, Warsaw, Poland, Pogonowska Milena , Guzek Aneta ,   Microbiology Laboratory of the Department of Laboratory Diagnostics, Military Institute of Medicine, Warsaw, Poland, Gościńska Agnieszka ,   Department of Paediatrics, Nephrology and Child Allergology, Military Institute of Medicine, Warsaw, Poland, Rustecka Agnieszka ,   Department of Paediatrics, Nephrology and Child Allergology, Military Institute of Medicine, Warsaw, Poland, Kalicki Bolesław ,   Department of Paediatrics, Nephrology and Child Allergology, Military Institute of Medicine, Warsaw, Poland
Published: June 2022

Seasonal outbreaks of respiratory syncytial virus are common among young children and represent an important clinical problem. The infection can affect all floors of the respiratory system. Respiratory syncytial virus is highly infectious and is the most common aetiological agent of bronchiolitis. It is estimated that 90% of children develop respiratory syncytial virus infection by the age of 2 years. In Poland and other countries of the northern hemisphere, these infections usually occur between October and May, with a peak in January–February. During the global COVID-19 pandemic, a significant change was observed in the epidemiology of respiratory syncytial virus infections in Europe and worldwide. The massive use of nonpharmacological interventions, such as closing nurseries, kindergartens, limited interpersonal contact, social distancing, strict hygiene rules and the use of protective masks, resulted in the absence or episodic occurrence of many seasonal infections, including those of respiratory syncytial virus aetiology, in 2020. In 2021, a so-called compensatory epidemic of syncytial virus aetiology was observed, i.e. a significant increase in the incidence associated with the extinction of collective immunity and an increasing proportion of susceptible individuals. The aim of the present study was to retrospectively analyse the incidence of respiratory syncytial virus infections in children hospitalised in the Department of Paediatrics, Paediatric Nephrology and Allergology of the Military Institute of Medicine in Warsaw in the years 2020–2021. We also discussed the prevention and treatment of infections, as well as the association of bronchiolitis with the development of asthma in children.
Paediatric autoimmune neuropsychiatric syndrome in recurrent acute bacterial pharyngitis – a case report
Authors:   Department of Otolaryngology, Polish Mother’s Memorial Hospital Research Institute, Łódź, Poland, Pepaś Renata , Przysło Łukasz ,   Department of Neurology, Polish Mother’s Memorial Hospital Research Institute, Łódź, Poland, Bieda Robert ,   Department of Otolaryngology, Polish Mother’s Memorial Hospital Research Institute, Łódź, Poland, Konopka Wiesław ,   Department of Otolaryngology, Polish Mother’s Memorial Hospital Research Institute, Łódź, Poland
Published: June 2022

Pharyngitis and tonsillitis, regardless of their aetiology, are one of the most frequent reasons for visiting a family doctor or a paediatrician. Nearly 85% of pharyngitis cases are viral. It is estimated that bacterial throat infection occurs in 15% of schoolage children and in 4–10% of adult patients. Streptococcus pyogenes is the most common cause of bacterial pharyngitis. PANDAS stands for paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. The term is used to describe a subgroup of children and adolescents who develop acute obsessive-compulsive disorder or tics as a result of group A streptococcal infection, such as tonsillitis. The aim of the paper is to describe a case of a 4-year-old boy who presented to the Laryngology Clinic due to recurrent tonsillitis, time-correlated with obsessive-compulsive disorder.
Giant intramuscular sternocleidomastoid lipoma
Authors:   Department of Otorhinolaryngology – Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia, Ghazali Liyana ,   Department of Otorhinolaryngology, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia, Haron Ali ,   Department of Otorhinolaryngology, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia, Mohamad Irfan ,   Department of Otorhinolaryngology – Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia, Hassan Aniza ,   Department of Pathology, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia
Published: June 2022

Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises between the muscle fibres and passes through the intermuscular septa. Due to the infiltrative nature of the tumour, recurrence rate is higher than in other subcutaneous lipomas. Complete surgical excision of lipoma is often regarded as a definitive treatment modality and longterm follow-up is mandatory. Here we report a case of a 49-year-old male presenting with huge left neck mass measuring 12 × 10 cm, which was successfully removed. Computed tomography scan of the neck showed a well-defined septated lesion with a fat component in the right sternocleidomastoid muscle, and the histopathology examination confirmed the diagnosis of well-circumscribed intramuscular sternocleidomastoid lipoma. Follow-up after one year showed no evidence of recurrence.
A gastro-oesophagealis refluxbetegség és a Barrett-nyelőcső sebészi kezelése
Authors: Simonka Zsolt , Paszt Attila , Kovách Kornél , Tóth Illés , Horváth Zoltán , Pieler József , Tajti János , Leprán Ádám , Tiszlavicz László , Németh István , Rosztóczy András , Lup Márton , Lázár György
Published: June 2022

Bevezetés

A Szegedi Tudományegyetem Sebészeti Klinika 100 éves évfordulójának tiszteletére közleményünkben a 2000. január 1-től 2021. május 31-ig a Szegedi Tudományegyetem Sebészeti Klinikán 779 esetben elvégzett antirefluxműtét tapasztalait foglaltuk össze. Részletes kivizsgálást követően az endoscopos kép és a funkcionális vizsgálatok eredményének birtokában a gasztroenterológus munkacsoporttal szoros együttműködésben döntöttünk a műtéti indikációról. Elsődleges műtéti indikációt gyakorlatunkban a konzervatív kezelésre nem reagáló refluxbetegség jelentette. Klinikánk gyakorlatában 98,2%-ban Nissen szerinti fundoplicatiót végeztünk. Elemeztük a posztoperatív szövődmények előfordulását. Hosszú távú utánkövetésben vizsgáltuk a fundoplicatio hatását a savas, illetve epés refluxra, valamint a betegek életminőségbeli javulását a Visick score, illetve a módosított GERD–HRQL-kérdőív segítségével. Saját vizsgálataink igazolták a savas és epés reflux kóroki szerepét a Barrett-nyelőcső kialakulásában, továbbá azt, hogy a laparoscopos antirefluxműtét hatékonyan állítja helyre az alsó nyelőcsősphincter működését és szűnteti meg a savas és epés refluxot. Ennek hatására a Barrett-nyelőcső bizonyos eseteiben regressziót várhatunk. A betegség heterogenitása miatt azonban a folyamatos endoscopos követés továbbra sem hagyható el.
The Ortodox Church in the Urals During the Great Patriotic War
Authors: Andrei Pecherin
Published: June 2022

By the summer of 1941, everything indicated that the Russian Orthodox Church was finishing its last months, if not days. Two decades and more of total persecution by the militant atheists in power had brought it literally “to its last stand”. The vast majority of Orthodox churches were closed, ruined, desecrated, or even demolished to the ground. According to some reports there were only two active churches for the entire vast territory from the TransUrals to the Pacific Ocean. The situation was no better with the clergy. Many thousands of them in earlier years were either shot or sent to camps (in fact, to a slow death), and those who remained free were forced to abandon their church ministries... But suddenly there came a turning point marked by the exact date - June 22, 1941, when the attack on the Soviet Union by Nazi Germany began the Great Patriotic War which raised the question of the very existence of our country and its multinational people. In this situation the authorities had involuntarily to think about muting internal divisions. The fight against religion was quickly curtailed, and in the end (two years later) the Orthodox Church was given "most favored treatment"... The clergy en masse took a patriotic stand from the early days of the war forgetting all past offenses and fully embracing the slogan "Everything for the front, everything for victory”. Some of its representatives fought with dignity in the ranks of the active army, others worked selflessly on the home front and those in church service (very few of them at first, but then their number grew steadily) were everywhere collecting funds for the defense. And their contribution to the Victory was greatly appreciated by the Soviet government; for the first time since 1917 clergy received government awards... In this article it is provided a comprehensive look at the activities of the Russian Orthodox Church during the Great Patriotic War within the borders of the "Great Urals" (and the territories surrounding it). Along with a synthesis of materials previously published the composition of the clergy serving at that time in a number of Ural regions was analyzed for the first time on the basis of the Ural Church-Historical Society database which, in particular, allowed to conclude about its multiple quantitative reduction and a sharp decline in qualitative level in comparison with the pre-revolutionary period.
Preservation and Loss of Christian Icons on the Territory of Komi-Permian District in the XX – Early XXI Century
Authors: Tatyana Goleva
Published: June 2022

The article is devoted to the problem of preservation/loss of religious objects in the Soviet and post-Soviet times on the territory of the Komi-Permyak District. The policy of looting churches and destruction of religious objects was adopted by the state since the beginning of the establishment of Soviet power in Russia At the same time the people reacted to these events in different ways, there were attempts to save both domestic and temple icons. These processes remain poorly studied since in historical science this topic has been under a ban for a long time. The relevance of the research is related to the increasing scientific interest in the issues of religiosity, the study of cultural and ethnic values. The goal of the study is to reveal and describe the processes of loss/conservation of icons on the territory of the Permian Komis' settlement during the 20th - early 21st centuries. The research is based on methods of oral history, memory study and folklore. The main sources were records of conversations with residents of Permian Komi settlements as well as observations of the author. In different years of the considered period certain "challenges", which became a threat to the preservation of icons, are mentioned. The closure of religious buildings, the persecution of believers and the exclusion of religious items from museum collections is only some of these challenges. There were people who, for ideological reasons, supported acts of destruction of icons; and there were also defenders and guardians of religious values. In cases of encroachment by the authorities on the images the way to save them was to steal these images from places of storage, hide them in houses, outbuildings, and in the ground. Until now there is a partial preservation and maintenance of folk customs related to icons. Most of the traditions contributed to the preservation of the images in the family homesteads and in the family circle. Stories about the abuse of icons or their salvation are known, as a rule, to a narrow circle of the local community. Many of the texts are characterized by laconic and fragmentary description of the events that took place.
A new approach based on integration of random subspace and C4.5 decision tree learning method for spatial prediction of shallow landslides
Authors: Nhu Viet-Ha , Bui Tinh Thanh , My Linh Nguyen , Vuong Hoe , Duc Hoang Nhat
Published: June 2022

The research approaches a new machine learning ensemble which is a hybridization of Random subspace (RS) and C4.5, named RandSub-DT, for improving the performance of the landslide susceptibility model. This is based on the GIS database, including 170 landslide polygons and ten predisposing landslide factors, i.e., slope, aspect, curvature, TWI, land use, distance to road, distance to the river, soil type, distance to fault, and lithology. We carried out this study in the Halong and Cam Pha City areas which are important economic centers in the Quang Ninh province, Vietnam, where landslides seriously influence the daily life of the citizen causing economic damage. We then used a GIS database to construct and validate the proposed RandSub-DT model. The model performance was assessed using a confusion matrix and a set of statistical measures. The result showed that the RandSub-DT model with the classification accuracy of 90.34% in the training dataset and the prediction capability of 77.48% had a high performance for landslide prediction. This research proved that an ensemble of the C4.5 and RS provided a highly accurate estimate of landslide susceptibility in the research area.
Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH
Authors: Kundu Shrishnu Kumar , Patra Susanta , Sardar Chayan , Bhanja Sunil Kumar , Patra Prasanta
Published: June 2022

A green one-pot synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives which are the main core of the natural product of Polyneomarline C is described by the reaction of 4-chloro-3-formyl coumarin and different cyclic and acyclic compounds having active methylene group in presence of Et3N and NH4OAc in EtOH. The advantages of this strategy are good yields, no need for the chromatographic separation and the absence of heavy metal catalysts and toxic by-products. The 4-chloro-3-formyl coumarin is obtained by Vilsmeier Heck reaction of 4-hydroxy coumarin.
Synthesis and evaluation of cerebroprotective activity of novel 6,7-dimethoxyquinazolin-4(3H)-one derivatives containing residues of amino acids and dipeptides
Authors: Chiriapkin Alexey S. , Kodonidi Ivan P. , Pozdnyakov Dmitry I.
Published: June 2022

Neurodegenerative processes of the central nervous system are an important socially significant problem of modern society. They cause many diseases, such as Alzheimer's disease and cerebral ischemia, which significantly reduce the quality of human life and can lead to disability or death. The aim of this study was to synthesize novel 6,7-dimethoxyquinazolin-4(3H)-one derivatives with the remains of neuroactive amino acids and dipeptides in order to investigate their cerebroprotective properties. As a result of the study, 13 novel 6,7-dimetho-xyquinazolin-4(3H)-one derivatives were synthesized. Cerebral ischemia in rats was reproduced by irreversible right-sided occlusion of the middle cerebral artery using the Tamura method, and the area of brain necrosis was evaluated. Cognitive functions were evaluated in the Y-maze test. Among the studied quinazolinone derivatives, compounds 3i, 3j and 3k have the most pronounced cerebrotropic activity, which is not inferior to ethylmethylhydroxypyridine succinate in terms of pharmacological activity, making them promising objects for further research.
Determination of optimal parameters technological process of polling of copper wire with alloy POS-61
Authors: Aleksandrova V. V. , Kuzmin M. V. , Patianova A. O. , Semenov V. L. , Alexandrov R. I.
Published: June 2022

The development of the technique for the manufacture of round copper wire coated with "tin-lead" alloy is considered. The optimal parameters such as the temperature of the "tin-lead" alloy melt, the linear speed for tinning of the wire with a round copper alloy and the diameter of the diamond die were determined. The test results of the experimental wire samples are presented.
Phytoextraction of toxic elements by Amaranthus Tricolor grown on technogenically polluted soils in open ground conditions
Authors: Gorelova Svetlana V. , Gins Murat S. , Frontasyeva Marina V.
Published: June 2022

Using the INAA method, the ability of Amaranthus tricolor L. variety “Valentina” growing on soils with different degree of pollution to extract heavy metals was evaluated in the field experiments. It was found that amaranth of the studied variety characterized by the content of betacianin pigment, amaranthine, in the shoots and generative organ, is able to accumulate elements such as Mn, Fe and Ni from soils. The content of most of the studied elements decreases in the following order: leaves inflorescences stems. Under conditions of soil pollution with emissions from metallurgical plant, the phytoextraction of such elements as Mn, Fe, Co, Sb increases. The content of Fe and Mn in the leaves of A. tricolor var. “Valentina” exceeds the average data for vegetation from 7 to 17 times; the Co content exceeds the average data for vegetable from 4 to 7 times; the Sb content in the leaves exceeds the average data for vegetable from 10 to 23 times. Due to the fact that amaranth forms a sufficient biomass for the growing season, it can be recommended for phytoextraction of heavy metals from soils in case of polymetallic pollution.
Zorunlu Suriyeli Göçü Bağlamında Türkiye’de Yurttaşlığı Yeniden Düşünmek
Authors: EZGİN Emre
Published: June 2022

Ulus-devlet anlayışı ekseninde mevcut yurttaşlık tanımı zorunlu göçlerin neden olduğu göçmen (öteki) gerçekliğini kapsamaktan ve kavramaktan uzak bir görünüm arz etmektedir. Türkiye’de ulus devlet anlayışının gelişim süreci dikkate alındığında, etnisist ve devleti kutsayan bir yurttaşlık algısının eğitim aracılığıyla inşa edilmesi nedeniyle çoğulcu ve kapsayıcı olmaktan uzak bir yurttaşlık söz konusudur. Bu bağlamda okul, söz konusu yurttaşlık algısının inşasında, seküler ve milliyetçi kaygılarla beslenen ve merkeziyetçi bir anlayışla denetlenebilen bir ulus kimliğin pekişmesinde işlevsel konumda yer almıştır. Bu nedenle, zorunlu Suriyeli göçü sonucu göçmenlerin yurttaşlığa entegrasyonuna dair taleplere cevap verme konusunda yetersiz kalınmakla birlikte, ulus devlet anlayışının hukuksal çerçevesi ve milliyetçi motivasyonu göçmenlerin ötekileştirilmesine ve kriminalleştirilmesine zemin hazırlamaktadır. Öyle ki, göçmenlerin yerleşikler tarafından dışlanması, göçmenlerin kendi içlerine dönerek sarsılmışların dayanışması bağlamında, kamusal temastan uzaklaşmasına, iletişimi kendileriyle benzer mağduriyetlere maruz kalan kitlelerle sınırlamalarına, yerel dile yönelik öğrenme isteklerinin azalmasına ve ihtiyaçlarını kayıt dışı ya da gayri meşru yollar aracılığıyla karşılamaya yönelmektedirler. Zorunlu göç sonucu göçmenler ve yerleşikler arasında yaşanan karşılıklı hoşnutsuzlukların çözümüne dair daha somut adımların atılabilmesi için “öteki”nin haklarına yönelik hassasiyeti kapsayan bir “dünya yurttaşlığı” anlayışına gereklilik söz konusudur. Bu çerçevede, iletişim, dinleme ve sorgulama hususları işlevselleştirilerek, yurttaşlığın yeniden düşünülmesi, görmezden gelinen tüm insani değerlerin görünür kılınması açısından önemlidir. Bu sayede göç etmek zorunda kalan göçmenlerin yerleşiklerle kurdukları toplumsal temas bağlamında, göçmenlerin tutunmalarına ve tanınmalarına zemin sağlayacak ahlaki olgunluğun ve sorumluluk duygusunun karşılıklı olarak pekişmesi muhtemel görünmektedir. Bununla birlikte farklılıkların indirgenmediği bir düzlemde, iletişim özgürlüğünün kamusal alanda katılımı ve etkileşimi tetikleyerek, kimlik temelli toplumsal açmazlara yönelik bir çözüm arayışına kapı aralanmaktadır.
The potential use of ozone as antifungal and antiaflatoxigenic agent in nuts and its effect on nutritional quality
Authors: Ali E. M. , Abdallah B. M.
Published: June 2022

Abstract Ozone gas is considered as a safe antimicrobial agent in food industries. Here, we evaluated the antifungal and antiaflatoxigenic activities of ozone against fungal contamination in nuts. The most predominant fungal genera in nuts were Aspergillus, Penicillium, Fusarium, and Rhizopus. Ozone (4 ppm) significantly reduced the fungal sporulation of A. flavus and their aflatoxin production. Interestingly, ozone treatment of nuts reduced the total fungal count and increased aflatoxins degradation by approximately 95% and 85%, respectively. Ozone displayed high efficiency to increase the permeability of cell membrane and injury of cell wall of fungi. Increasing the exposure time of ozone in nuts up to 180 minutes showed to reduce the total lipid, carbohydrates, and protein by around 41.2%, 42.7% and 38.4% respectively, in pistachio, almond and peanuts. In conclusion, ozonation is a suitable decontaminating approach for reducing the microbial load in nuts, when used with suitable exposure time.
Direitos humanos, encaixes institucionais e repertórios de ação: o Centro de Derechos Humanos de las Mujeres
Authors: Bernardi Bruno Boti
Published: June 2022

RESUMO Introdução: Neste estudo de caso da organização não governamental mexicana Centro de Direitos Humanos das Mulheres, discuto interpretações teóricas de Relações Internacionais sobre vínculos entre ativismo profissional, vítimas e atores de base. Analiso se a atuação de organizações não governamentais institucionalizadas pode gerar efeitos sóciopolíticos emancipatórios ou se, ao contrário, leva à desmobilização e ao silenciamento de demandas pró-direitos. Materiais e Métodos: Com base em entrevistas semiestruturadas e fontes secundárias, a pesquisa apresenta a trajetória institucional, repertórios de ação e perfil das pessoas fundadoras do Centro de Direitos Humanos das Mulheres do México. A hipótese foi a de que, nas práticas das organizações não governamentais, tanto formas de atuação mais e menos institucionalizadas, como ações de colaboração ou de confronto podem conviver sem que isso implique o afastamento desses grupos de suas bases sociais. Resultados: Contrariamente ao que é normalmente esperado pela literatura, a organização estudada equilibra dois papéis institucionais distintos ao mesmo tempo: o ativismo militante e a defesa legal. Isso lhe permite manter conexão com a radicalidade das lutas sociais e avançar em ações institucionalizadas junto ao Estado e a instâncias da governança global. Discussão: A literatura precisa enfocar melhor as interações reais entre instituições, organizações não governamentais e vítimas. É necessário problematizar as interpretações que enxergam o ativismo profissional apenas como um mercado tecnocrático do Norte global. É preciso olhar para as histórias locais de mobilização dos direitos humanos.
Impact of objective knowledge and self-assessed knowledge on the population's attitudes towards the Brazilian agribusiness
Authors: Borges João Augusto Rossi , Souza Kauê Felipe Ramos de , Domingues Carla Heloisa de Faria , Talamini Edson
Published: June 2022

Abstract In Brazil, positive and negative information is spread about agribusiness. In this context of positive and negative information, the population forms its attitudes towards Brazilian agribusiness. Attitudes are related to objective knowledge, that is, accurate scientific information or consolidated data the individual has in his/her memory, and self-assessed knowledge, that is, what the individual thinks she or he knows. The objective was to identify the impacts of objective knowledge and self-assessed knowledge about Brazilian agribusiness on the population's attitudes. Data were collected through the application of questionnaire to a sample of 468 participants. Data were analyzed using descriptive statistics, and an ordinal logistic regression model. The results show that the greater the objective knowledge and the greater the self-assessed knowledge, the greater the probability of an individual having a more positive attitudes towards Brazilian agribusiness. The results also show that the further to the right on the political spectrum the individual declared himself/herself, the greater the probability of showing more positive attitudes towards the Brazilian agribusiness.
Systematic review of the literature on Digital Twin: a discussion of contributions and a framework proposal
Authors: Cruz Richard Junior Maraschalchi da , Tonin Luiz Antonio
Published: June 2022

Abstract This study aimed to investigate the definitions, requirements and applications of Digital Twin (DT) models, and for that, a systematic literature review was carried out using Science Direct, Scopus and Web of Science as the bases for the articles. The method used was based on bibliometric analysis of the 332 articles extracted from the bases and a content analysis, which sought to identify contributions, common topics and gaps among the 17 articles that were filtered and identified as relevant to the second objective of this work, the framework proposal. The analyzed sample indicated that authors diverge on the definitions and use different processes to build a DT, models that seek to represent elements of the real environment, which could be products and/or processes/services, with the objective of being a tool for performance monitoring, simulation of scenarios and source of information for decision making. The use of software that often does not have trial licenses or versions for students was also observed in the sample, based on this point and on the analyzed content, an attempt was made to build a conceptual framework for the construction of a DT model in a game engine, using software that does not require licenses.
APPLICATION DEVELOPMENT TO SUPPORT THE DIAGNOSIS OF NURSES IN THE CARE OF SURGICAL PATIENTS
Authors: Paschoal Jociani Gonçalves , Fioresi Mirian , Bringuente Maria Edla de Oliveira , Morais Sheila Coelho Ramalho Vasconcelos , Primo Cândida Caniçali , Furieri Lorena Barros
Published: June 2022

ABSTRACT Objective: to develop a mobile application to support nurses’ diagnostic reasoning in the care of surgical patients Method: this is applied research with technological production, carried out in a hospital in the metropolitan region of Espírito Santo, from September 2018 to December 2019. The study was divided into four stages: theoretical content elaboration through an integrative literature review of the main signs and symptoms observed in patients in the postoperative period of gastrointestinal, thoracic, head and neck surgeries, and cross-mapping between the signs and symptoms found in the literature review and NANDA International nursing diagnoses; development of 10 case studies that foster clinical and surgical situations elaborated according to nursing diagnoses mapped according to Lunney’s framework; assessment of case studies by experts using content validity index; and application construction in partnership with a graphic design expert by the User-Centered Design method. Results: the application CuidarTech®Cirúrgico presents four navigation options: 1) “Nursing Process” - displays theoretical contents; 2) “Nursing diagnoses and actions” - with nursing diagnoses and interventions to assist patients in the postoperative period of gastrointestinal, thoracic, head and neck surgeries; 3) “Case studies” - brings 10 validated studies to training clinical reasoning; and 4) “Credits” - executing team. Conclusion: the application is an unprecedented technology and constitutes an interactive support in the care and teaching of nurses’ Nursing Process and clinical reasoning.