bluuebunny/crossref_metadata_2025 huggingface dataset:
EFEKTIVITAS KOMITE SEKOLAH DI SD NEGERI 7 BINGIN TELUK KABUPATEN MUSI RAWAS UTARA
Authors: Harti Sarina Dewi , Zakaria Zakaria
Published: February 2023

Tujuan penelitian ini adalah untuk mengetahui: (1) keefektifan komite sekolah dalam membuat komitmen masyarakat terhadap pendidikan bermutu untuk meningkatkan mutu pendidikan.       (2) keefektifan komite sekolah dalam bekerja sama dengan masyarakat dan pemerintah untuk menyelenggarakan pendidikan yang berkualitas. (3) efektivitas komite sekolah dalam memberikan pertimbangan dan rekomendasi kepada sekolah untuk meningkatkan mutu pendidikan.  (4) keefektifan komite sekolah dalam mendorong orang tua dan masyarakat untuk berpartisipasi dalam meningkatkan mutu pendidikan. (5) efektivitas komite sekolah dalam mengawasi kebijakan program dan penyelenggaraan sekolah untuk meningkatkan mutu pendidikan. (6) keefektifan kinerja komite sekolah dalam menyelenggarakan pendidikan yang bermutu. Jenis penelitiannya adalah penelitian evaluasi. Subjek penelitian ini adalah kepala sekolah, ketua panitia dan wakil panitia SD Negeri 7 Bingin Teluk, orang tua siswa SD Negeri 7 Bingin Teluk. Hasil penelitian sebagai berikut: (1) Memberi motivasi, sosialisasi, saran. Dilarang mengumpulkan dana. Meningkatkan kualitas layanan pendidikan. Menyampaikan program sekolah. (2) Mengakomodasi aspirasi dan keluhan. (3) Memberikan saran tentang proses manajemen pendidikan, jumlah guru, pemantauan guru dan pegawai staf. Sarankan sekolah untuk mengirim guru untuk menghadiri seminar, pelatihan dan lokakarya. Secara langsung mengontrol, memberikan gambaran tentang proses pembelajaran. Terlibat dalam perencanaan prasarana dan sarana. Beri ide pada draf. (4) Sosialisasi. Komunikasi. Mengakomodasi dan menganalisis aspirasi masyarakat. Mengevaluasi dan mengontrol kebijakan pendidikan.              (5) Memantau anggaran pendidikan sekolah, dan mengevaluasinya. Mengakomodasi dan menganalisis aspirasi. (6) Evaluasi kinerja. Melihat dan berinteraksi langsung semua kondisi. Sebagai mediator.
KEPUASAN SISWA TERHADAP FASILITAS PENDIDIKAN DI MTs NEGERI KABUPATEN KAUR
Authors: Hamidah Nur
Published: February 2023

Tujuan penelitian untuk menganalisis kepuasan siswa terhadap fasilitas pendidikan di MTs Negeri Kabupaten Kaur. Metode  penelitian deskriptif dengan pendekatan survey. Sampel penelitian ini  55 siswa  kelas IX MTs Negeri Kabupaten Kaur. Analisis data menggunakan skor rata-rata ideal (Mi) dan standar deviasi ideal (SDi) sebagai kriteria. Hasil penelitian (1) Kepuasan siswa terhadap penggunaan fasilitas pendidikan di MTs Negeri 1 Kaur dalam kategori memuaskan; (2) Kepuasan siswa terhadap penggunaan  fasilitas pendidikan di MTs Negeri 2 Kaur dalam kategori  memuaskan; (3) Kepuasan siswa terhadap penggunaan  fasilitas pendidikan di MTs Negeri 3 Kaur dalam kategori memuaskan; (4) Kepuasan siswa terhadap penggunaan  fasilitas pendidikan di MTs Negeri 4 Kaur dalam kategori  memuaskan; dan (5) Kepuasan siswa terhadap penggunaan fasilitas pendidikan di MTs Negeri  5 Kaur dalam kategori kurang memuaskan. Simpulan penelitian kepuasan siswa terhadap fasilitas pendidikan di MTs Negeri Kabupaten Kaur dalam kategori memuaskan
REALITA PENGANGKATAN KEPALA SEKOLAH DASAR NEGERI DI KECAMATAN ILIR TALO KABUPATEN SELUMA
Authors: Asri Asri , Sasongko Rambut Nur
Published: February 2023

Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan realita pengangkatan kepala sekolah dasar neegri di kecamatan Ilir Talo Kabupaten Seluma. Metode Penelitian ini merupakan studi kasus dengan menggunakan pendekatan kualitatif deskriptif. Hasil penelitian menunjukkan: Kepala sekolah negeri di kecamatan Ilir Talo Kabupaten Seluma, masih ada 2 orang kepala sekolah yang masih belum sesuai dengan standar pengangkatan kepala sekolah sesuai dengan peraturan Menteri Pendidikan Nasional Nomor 13 Tahun 2007 tentang standar Kepala Sekolah/Madrasah kualifikasi kepala sekolah/madrasah.
Konsep Pemikiran Ekonomi Islam Imam Al Ghazali
Authors: Arrafi Muhamad Faiz , Marwini Marwini , Dja'akun Cita Sary
Published: February 2023

This article describes Al-Ghazali's thoughts in the field of economics through his monumental work Ihya 'Ulum Al-Adin. Al-Ghazali explained thoroughly the aspects of substance in Islamic economics. Al-Ghazali lived in an era where rulers tried to justify their actions by asking religious leaders for fatwas with the intention of justifying these actions. Al-Ghazali entered the second phase in the history of Islamic economic thought. The second phase started in the 11th century until the 15th century. In this second phase many faced political realities marked by the many acts of corruption among the authorities and accompanied by moral decadence which resulted in a wider gap between the rich and the poor. Al-Ghazali implemented an Islamic economic system using a Sufism approach, because during his lifetime it was difficult for people who were rich, powerful, and full of prestige to accept the fiqh and philosophical approach in believing in Yaum al-Hisab (the Day of Judgment).
Implementasi Strategi Manajemen Pemasaran Bank Syariah di Era Revolusi Industri 4.0 di Indonesia
Authors: Putri David Nabila Arifa Aprilia , Fasa Muhammad Iqbal , Suharto Suharto
Published: February 2023

Strategi pemasaran adalah suatu suatu prosedur pemasaran yang terencana dan terstruktur yang akan dilakukan untuk mencapai tujuan perusahaan. Seiring dengan berkembangnya suatu perusahaan, maka persaingan perusahaan tidak dapat dihindari, terutama di dunia perbankan. Rumusan masalah dalam penelitian ini adalah bagaimana strategi untuk pemasaran perbankan syariah agar tetap maju serta eksis di era revolusi industri keempat ini. Penelitian ini bertujuan untuk mengetahui bagaimana implementasi strategi manajemen pemasaran bank syariah di era revolusi industri 4.0 di Indonesia saat ini. Penelitian ini merupakan penelitian kualitatif melalui pengumpulan data yang detail serta mendalam dengan melibatkan beragam sumber informasi. Hasil penelitian yang di dapat adalah, pengembangan strategi pemasaran perbankan syariah, yaitu optimalisasi produk yang mendorong optimalisasi keuntungan bisnis, meningkatkan kualitas SDM, meningkatkan kecanggihan teknologi serta meningkatkan kuaitas produk. Adapun pengembangan strategi pemasaran bank syariah dengan analisis SWOT, yaitu: 1) Strategi Strengths-Opportunities, 2) Strategi Weaknesses-Opportunities, 3) Strategi Strengths-Threats, 4) Strategi  Weaknesses-Threats.
Non-Alcoholic Fatty Liver Disease (NAFLD): The Search for a Cure
Authors: Abdulla Alabagi , Reynolds Charity , Hesham A-Kader H
Published: February 2023

An alarming rise of obesity and, along with it, non-alcoholic fatty liver disease (NAFLD), has been observed in the USA and the rest of the world. NAFLD, the most common cause of chronic liver disease in many developed countries, is not always a benign disorder and considering its growing nature, will have a serious impact on healthcare systems worldwide. The search continues for a suitable therapy for this disorder; the therapy ideally needs to be safe, effective, and affordable. The biggest hurdle in the process of developing such a therapy is our lack of a complete understanding of the pathogenesis of the disease.
Conquering C – Going Beyond Cure
Authors: Bell Juliet
Published: February 2023

Prof Zeuzem opened the symposium by acknowledging that there is a new era in hepatitis C virus (HCV) treatment, due to the availability of efficacious treatments that could eradicate the disease. Prof Pawlotsky outlined recent advances in the field of HCV and discussed the European Association for the Study of the Liver (EASL) Recommendations on Treatment of Hepatitis C 2015, which were released at the congress. These recommendations prioritise the available HCV treatments in Europe, from treatment-naïve to treatment-experienced patients and in the context of patients with various stages of HCV disease, and highlight the need to remain vigilant for possible drug–drug interactions (DDIs) between HCV direct-acting antiviral agent (DAA) treatments and regular pharmaceutical medications. Dr Bourlière then described the remaining challenges in HCV relating to treatment of certain patient populations, such as those with advanced disease and specific contraindications. Prof Foster presented the real-life challenges of treating a patient population that can have heterogeneous characteristics and presented the recent outcomes of nationally implemented programmes for HCV. Mr Charles Gore, a patient advocate, described the World Health Organization (WHO) policies in HCV and highlighted that government lobbying by physicians and patients was required to improve awareness and prioritise HCV treatment. Prof Afdhal then summarised the current impact of HCV on productiveness and patient outcomes, and spoke about the benefits of patient access programmes in expanding the pool of patients who can be treated along with the cost implications of the global eradication of HCV. Finally, Prof Zeuzem emphasised how HCV is currently perceived as a lower global priority compared with other viral diseases and that lobbying will be required to demonstrate how investments into the treatment of HCV patients would dramatically reduce the prevalence and long-term costs of the disease.
Answering Pivotal Questions in the Diagnosis and Treatment of Primary Biliary Cirrhosis and Non-Alcoholic Steatohepatitis
Authors: Legg Ewen
Published: February 2023

Professor Trauner introduced the subject of liver disease and its burden within the European Union (EU) and across the globe. Professor Jones summarised the progress made in understanding the pathophysiology of primary biliary cirrhosis (PBC), current unmet needs in the ursodeoxycholic acid (UDCA) era, and novel therapeutic options for PBC treatment. Professor Ratziu discussed the emerging understanding of the complex multisystem pathophysiology of non-alcoholic steatohepatitis (NASH), summarised the available therapeutic targets, and detailed the trials of novel agents currently underway.
The Value of Colon Cancer Screening in Developing Countries
Authors: Dan-Nicolae Bele
Published: February 2023

Abstract Objectives: Colorectal cancer is the third most diagnosed cancer worldwide and the second most common cause of cancer death. If diagnosed at an early stage, however, it is one of the most curable malignancies. Patients with biopsy-proven adenocarcinoma of the colon without evidence of distant metastasis, and without contraindications to major surgery, are commonly treated with surgical resection. Methods and results: A 49-year-old male patient without any significant history is admitted at Surgery 5 Service, Cluj-Napoca for abdominal pain, diarrhoea, and important weight loss in the last 7 months. CT showed thickening of the sigmoid colon as well as bladder and small bowel invasion. The final diagnosis was completed by a colonoscopy and biopsy which was of stenotic sigmoid tumour, chemo treated. Unfortunately, the chemotherapy was unsuccessful, as the tumour did not regress. A multidisciplinary team was gathered debating the possibility of pelvic exenteration. As of surgical treatment, the following were performed: Sigmoidectomy with manual colo-rectal T-T anastomosis and central lymphadenectomy, ileal segmental resection with manual T-T anastomosis, resection of 2/3 of bladder, jejunostomy, evacuation of bladder abscess and the introduction of a double J ureteral stent. Consecutive to all procedures, the patient is in good health and can live a normal life. Conclusion: Even though surgery is curative in most cases of colorectal cancer, the survival rate of unoperated colorectal cancer is 0%. Thus, it is of utmost importance to diagnose colorectal cancer as soon as possible. Identification of populations at risk and screening of asymptomatic patients are therefore crucial imperatives.
Peran Humas Pemerintah D.I Yogyakarta sebagai Boundary Spanner antara Pemerintah Daerah dengan Stakeholders
Authors: Maulida Rizkiya Ayu
Published: February 2023

Penelitian ini bertujuan menggali peran humas pemerintah daerah D.I Yogyakarta dalam menjembatani komunikasi antara pemerintah daerah dengan para pemangku kepentingan. Menurut teori sistem, humas berperan sebagai boundary spanner dalam suatu lingkungan tempat ia berada. Bagaimana peran tersebut dijalankan sangat dipengaruhi oleh lingkungan tempat humas tersebut berada.  Provinsi DI Yogyakarta merupakan suatu daerah yang memiliki status keistimewaan, yang membedakan dengan provinsi lain. Pengumpulan data dilakukan dengan metode wawancara dan observasi. Hasil penelitian menunjukkan bahwa humas Pemeda DIY memiliki peran yang signifikan sebagai boundary spanner antara Pemda DIY dan lingkunagn sekitar. Hal tersebut ditunjukkan dengan keterlibatan humas Pemda DIY dalam membantu menjembatani hubungan publik dengan lembaga pemerintah tingkat daerah lain yang berada di Provinsi DIY.  Selain itu, humas Pemda DIY juga memiliki peran sebagai penasihat dalam membuat kebijakan yang terkait komunikasi.  Akan tetapi, humas Pemda DIY belum memiliki kewenangan dalam membuat kebijakan terkait komunikasi. Penelitain lanjutan dibutuhkan dalam menganalisa praktik boundary spanner pada pemerintah daerah lain yang memiliki perbedaan sistem pemerintahan dan sosial-budaya dengan D.I Yogyakarta.
ДОСЛІДЖЕННЯ ВЛАСТИВОСТЕЙ МАЛОУСАДКОВИХ БЕТОНІВ ДЛЯ SEAMLESS FLOOR TECHNOLOGY, ЩО РОЗРОБЛЕНІ ІННОВАЦІЙНИМ ЦЕНТРОМ КОМПАНІЇ ТОВ «АСТОР і КО» З КОМПЛЕКСНОЮ ДОБАВКОЮ ФІРМИ ТОВ «МАПЕІ УКРАЇНА»
Authors: Admin Admin , Шейніч Леонід , Миколаєць Максим , Крилов Євгеній , СУРМАЧЕВСЬКИЙ Андрій , ЯЩЕНКО Євгеній , ПУШКАРЬОВА Катерина
Published: February 2023

В статті викладені відомості щодо отриман-ня безусадних бетонів. Досліджені процесидеформацій спеціальних малоусадних бетонів дляseamless floor technology. Ці бетони розробленіспеціалістами Інноваційного центру ТОВ «Асторі КО» та ТОВ «Мапеі Україна». Для розробле-них бетонів притаманний складний грануломе-тричний склад, застосування різних цементів тавикористання хімічних добавок Dynamon SR3(суперпластифікатор), Expancrete (розширююча добавка), Mapecure SRA25. Проаналізовані з ура-хуванням умов тверднення технологічні операціїотримання безусадних та розширюючих бетонів.Показано, що на ранніх етапах тверднення запро-понованих бетонів спостерігаються деформаціїрозширення, а потім незначні деформації усад-ки. Максимальна величина деформацій розши-рення бетону зафіксована на 3 добу тверднен-ня в нормальних умовах. Так, вона для бето-ну на цементі ПЦІІ/А-Ш-500Р-Н деформація

розширення складає +0,568 мм/м, в той час,а для бетону на цементі ПЦІІ/А-В-500Р-Н -+0,494 мм/м. Встановлено, що процеси розши-рення бетону в перші терміни тверднення пояс-нюються наявністю вологості, яка сприяє утво-ренню новоутворень подібних природномуеттрингіту, що потребує для свого синтезу значноїкількості води. В подальші терміни твердненнябетонів в повітряно сухих умовах, що приближенідо умов тверднення в початкові терміни длябетонів підлог, відбувається незначна їх усадка.Подальші деформації усадки менші для бетонівна цементі ПЦІІ/А-В-500Р-Н, ніж для бетонівз цементу ПЦІІ/А-Ш-500Р-Н. В склад цементуПЦІІ/А-В-500Р-Н входить вапняк. Встановлено задопомогою електронномікроскопічного аналізу,що в бетоні на цементі ПЦІІ/А-В-500Р-Н з часомутворюються значно більша кількість новоутво-рень подібних еттрингіту, але з вмістом Са(СО)3,ніж для бетону на цементі ПЦІІ/А-В-500Р-Н.Тому значення деформацій усадки бетону в часіна цементі ПЦІІ/А-В-500Р-Н незначні. Отриманірезультати вимірювання деформацій бетону коре-люють з даними, отриманими на підприємствіМapei Italy. Отримані результати підтверджені впромислових умовах при облаштуванні підлогпо – seamless floor technology.
Методика оцінки мінімальних вимог до показників енергоефективності житлових та громадських будівель
Authors: Farenyuk G G , Farenyuk E G
Published: February 2023

Мінімальні вимоги енергетичної ефективності будівель встановлюються відповідно до статті 6 Закону України «Про енергетичну ефективність будівель».Оптимальність витрат визначається як найбільш економічно ефективний варіант продукції або виробу шляхом порівняння витрат життєвого циклу різних варіантів. Аналітичні дослідження роботиосновані на методі, який вста-новлений Директивою щодо енергоефективності будівель (EPBD) 2010/31/ЄС та в делегованому Регламенті (ЄС) 244/2012. Порівняння показників енергоефективності за їх фізичними індикаторами у різних країнах є некоректними не тільки внаслідок різних кліматичних умов. Оптимальне значення показника енергоефективності будівлі визначається економічними умовами країни у існуючий час, точністю прогнозу зміни економічних показників на протязі проектного терміну служби об’єкту, структурою ринку будівельних матеріалів, виробів, конструкцій, інженерного устаткування у конкретній країні та її енергетичного ринку. У статті наводяться методичні принципи із вста-новлення для будівель-еталонів оптимальних значень показників енергоефективності, методи-ка розрахунку мінімальних вимог до показників енергоефективності будівель з урахуванням вартості інвестиційних вкладень у створення необхідної теплоізоляційної оболонки будівель та інженерних систем, їх обслуговування і вартості енергетичних витрат під час експлуатації жит-лових та громадських будівель у встановлених температурних зонах України. Стаття розкриває методологію визначення мінімальних вимог до енергоефективності, які регламентуються держав-ними будівельними нормами та відповідного нака-зу згідно вимог Закону України «Про енергетичну ефективність будівель».
Improving the methods of visual inspection of buildings and engineering structures through the introduction of computer vision and intelligent data processing technologies
Authors:   Siberian State University of Geosystems and Technologies, Bugakova T. Yu. , Sharapov A. A. ,   Siberian State University of Geosystems and Technologies
Published: February 2023

For the safe operation of engineering facilities, periodic surveys are carried out to assess their technical condition. To form an expert opinion and establish cause-and-effect relationships of changes in the state of an object from the influence of external factors, the first in the sequence of work, according to the terms of reference, is a visual inspection of the object or a visual inspection. As a result of visual inspection, it is possible to fix the occurrence of cracks in structures, the formation of a corrosion layer that damages structures, violations of the protective layer of the surfaces under study, violations of the paintwork of elements and parts of the structure of the object, etc. In order to improve the visual inspection technique, a hardware-software complex has been developed that makes it possible to apply computer vision technologies to provide automated visual monitoring of an object and analyze the obtained images by using intelligent algorithms for their processing. The use of a hardware-software complex for automated visual monitoring of an object in real time will allow performing: automated visual monitoring of a plurality of structural elements of an object at the same time due to a stationary installation of a network of video cameras at the object; intelligent analysis of the stream of video im-ages in real time, as a result of which information is given not only on the defects present, found on the object, but on the dynamics of their changes; identify defects in structural elements in hard-to-reach places where they cannot be visually determined, but it is possible to install a video camera; minimize the human factor.
Russian experience in the development, creation and application of precision hydrostatic leveling devices at scientific, civil and industrial facilities
Authors:   Moscow State University of Geodesy and Cartography, Vasyutinskiy I. Y. , Vasyutinskaya S. I. ,   Moscow State University of Geodesy and Cartography, Buyukyan S. P. ,   Monitron LLC, Kuzyanov N. A. ,   Monitron LLC
Published: February 2023

In chronological order, the process of developing and using hydrostatic leveling devices in the country, providing precision accuracy of the altitude position of the observed objects during operation or construction and the remoteness of obtaining the necessary information, is considered. The first hydrostatic leveling systems of this kind, based on the contact method of registering the position of the liquid level in vessels, were developed and installed at high-energy physics facilities to monitor the altitude position of the electromagnets of the Yerevan synchrotron and Serpukhov synchrophasotron. In the future, special attention was paid to devices and systems based on the contactless method of automated counting and processing of information using computer technology, which significantly reduced measurement errors to a fraction of a millimeter and time to units of seconds. The schematic diagram of the video level camera device, which has received consistent development, is considered. Most of the developed devices are patented. Based on the latest developments of video hydrostatic leveling devices, as their designs and characteristics are improved, work has been carried out to monitor high-altitude deformations of civil and construction facilities. The considered developments can be used to observe deformations of large construction objects during operation, for example, hydroelectric dams, during high-rise construction (skyscrapers), etc.
Gravimetric knowledge analysis of the Novosibirsk region territory according to ground measurements data
Authors:   Siberian State University of Geosystems and Technologies, Ganagina I. G. , Kobeleva N. N. ,   Siberian State University of Geosystems and Technologies, Goldobin D. N. ,   Siberian State University of Geosystems and Technologies, Zverev I. V. ,   Siberian State University of Geosystems and Technologies
Published: February 2023

The aim of the work is the analysis of the gravimetric knowledge of the Novosibirsk Region territory based on ground-based measurements presented as mixed gravity anomalies makes it possible to as-sess the reliability and quality of information about the characteristics of the Earth's gravitational field and use it to solve problems of the economy and the defense capability of the state, taking into account the demand and accuracy range. The results of gravity acceleration measurements on the territory of the Novosibirsk region and its immediate surroundings (in the hundred-kilometer zone – the territory of the Tomsk, Omsk, Kemerovo regions and Altai Territory) were obtained from the archives of the Federal State Institution "TFGI for the Siberian Federal District". Archival data of the gravity surveys results were digitized, systematized and analyzed. Particular attention is paid to the gravimetric study of the territory of the Novosibirsk region. The results of the gravimetric information analysis are presented in the form of cartograms. The paper compares ground-based gravimetric information for the study area with the data of the modern global geopotential model XGM2019e_2159. The root mean square error of the discrepancy between the model data and ground information is 3.8 mGal in the range of differences from +14 to -12 mGal. The results of the study allow us to conclude that it is possible to use ground-based gravimetric measurements obtained in the study area for regional modeling of the characteristics of the gravitational field
Assessment of distant-site rescue elements for CRISPR toxin-antidote gene drives
Authors: Chen Jingheng , Xu Xuejiao , Champer Jackson
Published: February 2023

Gene drive is a genetic engineering technology that can enable super-mendelian inheritance of specific alleles, allowing them to spread through a population. New gene drive types have increased flexibility, offering options for confined modification or suppression of target populations. Among the most promising are CRISPR toxin-antidote gene drives, which disrupt essential wild-type genes by targeting them with Cas9/gRNA. This results in their removal, increasing the frequency of the drive. All these drives rely on having an effective rescue element, which consists of a recoded version of the target gene. This rescue element can be at the same site as the target gene, maximizing the chance of efficient rescue, or at a distant site, which allows useful options such as easily disrupting another essential gene or increasing confinement. Previously, we developed a homing rescue drive targeting a haplolethal gene and a toxin-antidote drive targeting a haplosufficient gene. These successful drives had functional rescue elements but suboptimal drive efficiency. Here, we attempted to construct toxin-antidote drives targeting these genes with a distant-site configuration from three loci in Drosophila melanogaster. We found that additional gRNAs increased cut rates to nearly 100%. However, all distant-site rescue elements failed for both target genes. Furthermore, one rescue element with a minimally recoded sequence was used as a template for homology-directed repair for the target gene on a different chromosomal arm, resulting in the formation of functional resistance alleles. Together, these results can inform the design of future CRISPR-based toxin-antidote gene drives.
Case studies of multihazard damage: Investigation of the interaction of Hurricane Maria and the January 2020 earthquake sequence in Puerto Rico
Authors: Hain Alexandra , Zaghi Arash E. , Padgett Jamie E. , Tafur Anibal
Published: February 2023

This paper is motivated by the unique findings and observations from reconnaissance visits after the earthquake series in Puerto Rico in January 2020. It aims to discuss the potential interactions of Hurricane Maria and 2020 earthquake series and the considerations they underscore for future field reconnaissance missions. Traditionally, post-disaster damage assessment activities focus on one hazard and overlook the potentially cascading effects of multiple hazards on structures and infrastructure. This paper provides case studies showing the possible interaction of multiple hazards and their cascading effects observed in Puerto Rico. Infrastructure surveyed includes port facilities, buildings (particularly historical structures), and bridge structures. The data collected during the reconnaissance missions reveal how the impacts of Hurricane Maria, along with infrastructure aging and delayed repair and recovery activities, may have influenced the damage level and failure modes observed during the earthquake sequence a few years after. These case studies illustrate the nature of multihazard interactions and how these effects should be documented during post-disaster assessments. Beyond the insights gained from the case studies illustrated in this paper, the field survey instrument is provided as a basis for future reconnaissance studies, and the full set of reconnaissance data collected are published on the NSF funded NHERI DesignSafe cyberinfrastructure. As a result, this work not only provides data from Puerto Rico that can inform future damage and recovery modeling efforts, but also offers survey instruments and a field data collection process that is particularly tailored to cases where multihazard effects are at play.
Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis
Authors: Li Ziqi , Hou Pengwei , Mu Shuwen , Wang Renzhi , Miao Hui , Feng Ming , Wang He , Zhang Wentai , Chen Yihao , Feng Tianshun , Wang Shousen , Fang Yi
Published: February 2023

Objective

COVID-19 infection may affect thyroid function. However, changes in thyroid function in COVID-19 patients have not been well described. This systematic review and meta-analysis assess thyroxine levels in COVID-19 patients, compared with non-COVID-19 pneumonia and healthy cohorts during the COVID-19 epidemic.

Methods

A search was performed in English and Chinese databases from inception to August 1, 2022. The primary analysis assessed thyroid function in COVID-19 patients, comparing non-COVID-19 pneumonia and healthy cohorts. Secondary outcomes included different severity and prognoses of COVID-19 patients.

Results

A total of 5873 patients were enrolled in the study. The pooled estimates of TSH and FT3 were significantly lower in patients with COVID-19 and non-COVID-19 pneumonia than in the healthy cohort (P < 0.001), whereas FT4 were significantly higher (P < 0.001). Patients with the non-severe COVID-19 showed significant higher in TSH levels than the severe (I2 = 89.9%, P = 0.002) and FT3 (I2 = 91.9%, P < 0.001). Standard mean differences (SMD) of TSH, FT3, and FT4 levels of survivors and non-survivors were 0.29 (P= 0.006), 1.11 (P < 0.001), and 0.22 (P < 0.001). For ICU patients, the survivors had significantly higher FT4 (SMD=0.47, P=0.003) and FT3 (SMD=0.51, P=0.001) than non-survivors.

Conclusions

Compared with the healthy cohort, COVID-19 patients showed decreased TSH and FT3 and increased FT4, similar to non-COVID-19 pneumonia. Thyroid function changes were related to the severity of COVID-19. Thyroxine levels have clinical significance for prognosis evaluation, especially FT3.
Drug-induced mitochondrial toxicity: Risks of developing glucose handling impairments
Authors: Kuretu Auxiliare , Arineitwe Charles , Mothibe Mamosheledi , Ngubane Phikelelani , Khathi Andile , Sibiya Ntethelelo
Published: February 2023

Mitochondrial impairment has been associated with the development of insulin resistance, the hallmark of type 2 diabetes mellitus (T2DM). However, the relationship between mitochondrial impairment and insulin resistance is not fully elucidated due to insufficient evidence to support the hypothesis. Insulin resistance and insulin deficiency are both characterised by excessive production of reactive oxygen species and mitochondrial coupling. Compelling evidence states that improving the function of the mitochondria may provide a positive therapeutic tool for improving insulin sensitivity. There has been a rapid increase in reports of the toxic effects of drugs and pollutants on the mitochondria in recent decades, interestingly correlating with an increase in insulin resistance prevalence. A variety of drug classes have been reported to potentially induce toxicity in the mitochondria leading to skeletal muscle, liver, central nervous system, and kidney injury. With the increase in diabetes prevalence and mitochondrial toxicity, it is therefore imperative to understand how mitochondrial toxicological agents can potentially compromise insulin sensitivity. This review article aims to explore and summarise the correlation between potential mitochondrial dysfunction caused by selected pharmacological agents and its effect on insulin signalling and glucose handling. Additionally, this review highlights the necessity for further studies aimed to understand drug-induced mitochondrial toxicity and the development of insulin resistance.
Adrenal crisis in infants and young children with adrenal insufficiency: Management and prevention
Authors: Bizzarri Carla , Capalbo Donatella , Wasniewska Malgorzata Gabriela , Baronio Federico , Grandone Anna , Cappa Marco
Published: February 2023

Background

Despite the optimization of replacement therapy, adrenal crises still represent life-threatening emergencies in many children with adrenal insufficiency.

Objective

We summarized current standards of clinical practice for adrenal crisis and investigated the prevalence of suspected/incipient adrenal crisis, in relation to different treatment modalities, in a group of children with adrenal insufficiency.

Results

Fifty-one children were investigated. Forty-one patients (32 patients <4 yrs and 9 patients >4 yrs) used quartered non-diluted 10 mg tablets. Two patients <4 yrs used a micronized weighted formulation obtained from 10 mg tablets. Two patients <4 yrs used a liquid formulation. Six patients >4 yrs used crushed non-diluted 10 mg tablets. The overall number of episodes of adrenal crisis was 7.3/patient/yr in patients <4yrs and 4.9/patient/yr in patients >4 yrs. The mean number of hospital admissions was 0.5/patient/yr in children <4 yrs and 0.53/patient/yr in children >4 yrs. There was a wide variability in the individual number of events reported. Both children on therapy with a micronized weighted formulation reported no episode of suspected adrenal crisis during the 6-month observation period.

Conclusion

Parental education on oral stress dosing and switching to parenteral hydrocortisone when necessary are the essential approaches to prevent adrenal crisis in children.
To extract or not to extract? Influence of chemical extraction treatment of wood samples on element concentrations in tree-rings measured by X-ray fluorescence
Authors: Scharnweber T. , Rocha E. , González Arrojo A. , Ahlgrimm S. , Gunnarson B. E. , Holzkämper S. , Wilmking M.
Published: February 2023

In micro-densitometry of wood it is standard procedure to extract resin and other soluble compounds before X-ray analysis to eliminate the influence of these extractives on wood-density. Dendrochemical studies using X-ray fluorescence analysis on the other hand are commonly conducted without previous extraction. However, it is well known that translocation processes of elements during heartwood formation in trees or (temporal) differences in sap content of wood samples can influence dendrochemical element profiles. This might bias environmental signals stored in time series of element concentrations in wood proxies. We hypothesize that metals tightly bound to cell walls show a more robust proxy potential for environmental conditions than easily translocated ones. To eliminate the noise of these soluble substances in wood elemental time series, their extraction prior to analysis might be necessary. In our study we tested the effect of different solvents (water, alcohol, and acetone) and different extraction times on elemental time series of three tree species with differing wood structure (Pinus sylvestris; Quercus robur and Populus tremula). Micro-XRF analysis was conducted on nine replicates per species using an ITRAX-Multiscanner. A set of elements commonly detected in wood (S, Cl, K, Ca, Ti, Mn, Fe, and Ni) was analysed at high resolution before and after several extraction runs. Besides lowering their levels, extraction did not significantly change the temporal trends for most elements. However, for some elements, e.g., Potassium, Chlorine or Manganese, especially the water extraction led to significant decreases in concentrations and altered temporal trends. Apparently the dipole effect of water produced the strongest extraction power of all three solvents. In addition we observed a dependency of extraction intensity from wood density which differed between wood types. Our results help in interpreting and evaluating element profiles and mark a step forward in establishing dendrochemistry as a robust proxy in dendro-environmental research.
The impact of the CEO’s green ecological experience on corporate green innovation—The moderating effect of corporate tax credit rating and tax burden
Authors: Wang Lixia , Li Yan , Lu Sangying , Boasson Vigdis
Published: February 2023

Using the data of listed companies in the Chinese capital market from 2014 to 2020, this paper studies the impact of the CEO’s green ecological experience on corporate green innovation and further analyzes the moderating effects of tax credit rating and tax burden. The results show that 1) the CEO’s green ecological experience can enhance corporate green innovation, 2) China’s tax credit rating positively moderates the impact of the CEO’s green ecological experience on corporate green innovation, and 3) corporate tax burden will negatively moderate the impact of the CEO’s green ecological experience on corporate green innovation.
Comparative mitogenomes reveal diverse and novel gene rearrangements in the genus Meteorus (Hymenoptera: Braconidae)
Authors: Shu Xiaohan , Yuan Ruizhong , Xia Zhilin , Gao Gui , Yang Lei , Sun Zhirong , Mu Qing , Tang Pu , Chen Xuexin
Published: February 2023

Meteorus Haliday, 1835 is a cosmopolitan genus within Braconidae (Hymenoptera). They are koinobiont endoparasitoids of Coleoptera or Lepidoptera larvae. Only one mitogenome of this genus was available. Here, we sequenced and annotated three mitogenomes of Meteorus species, and found that the tRNA gene rearrangements in these mitogenomes were rich and diverse. Compared with the ancestral organization, only seven tRNAs (trnW, trnY, trnL2, trnH, trnT, trnP and trnV) were conserved and trnG had its own unique location in the four mitogenomes. This dramatic tRNA rearrangement was not observed in mitogenomes of other insect groups before. In addition, the tRNA cluster (trnA-trnR-trnN-trnS1-trnE-trnF) between nad3 and nad5 was rearranged into two patterns, i.e., trnE-trnA-trnR-trnN-trnS1 and trnA-trnR-trnS1-trnE-trnF-trnN. The phylogenetic results showed that the Meteorus species formed a clade within the subfamily Euphorinae, and were close to Zele (Hymenoptera, Braconidae, Euphorinae). In the Meteorus, two clades were reconstructed: M. sp. USNM and Meteorus pulchricornis forming one clade while the remaining two species forming another clade. This phylogenetic relationship also matched the tRNA rearrangement patterns. The diverse and phylogenetic signal of tRNA rearrangements within one genus provided insights into tRNA rearrangements of the mitochondrial genome at genus/species levels in insects.
An immune genes signature for predicting mortality in sepsis patients
Authors: Lin Shirong , Li Ping , Yang Jibin , Liu Shiwen , Huang Shaofang , Huang Ziyan , Zhou Congyang , Liu Ying
Published: February 2023

A growing body of evidence indicates that the immune system plays a central role in sepsis. By analyzing immune genes, we sought to establish a robust gene signature and develop a nomogram that could predict mortality in patients with sepsis. Herein, data were extracted from the Gene Expression Omnibus and Biological Information Database of Sepsis (BIDOS) databases. We enrolled 479 participants with complete survival data using the GSE65682 dataset, and grouped them randomly into training (n = 240) and internal validation (n = 239) sets based on a 1:1 proportion. GSE95233 was set as the external validation dataset (n=51). We validated the expression and prognostic value of the immune genes using the BIDOS database. We established a prognostic immune genes signature (including ADRB2, CTSG, CX3CR1, CXCR6, IL4R, LTB, and TMSB10) via LASSO and Cox regression analyses in the training set. Based on the training and validation sets, the Receiver Operating Characteristic curves and Kaplan-Meier analysis revealed that the immune risk signature has good predictive power in predicting sepsis mortality risk. The external validation cases also showed that mortality rates in the high-risk group were higher than those in the low-risk group. Subsequently, a nomogram integrating the combined immune risk score and other clinical features was developed. Finally, a web-based calculator was built to facilitate a convenient clinical application of the nomogram. In summary, the signature based on the immune gene holds potential as a novel prognostic predictor for sepsis.
Research into the characteristic molecules significantly affecting liver cancer immunotherapy
Authors: Chen Junhong , Jin Hengwei , Zhou Hao , Hei Xufei , Liu Kai
Published: February 2023

Background

The past decade has witnessed unprecedented scientific breakthroughs, including immunotherapy, which has great potential in clinical applications for liver cancer.

Methods

Public data were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases and analyzed with R software.

Results

The LASSO and SVM-RFE machine learning algorithms identified 16 differentially expressed genes (DEGs) related to immunotherapy, namely, GNG8, MYH1, CHRNA3, DPEP1, PRSS35, CKMT1B, CNKSR1, C14orf180, POU3F1, SAG, POU2AF1, IGFBPL1, CDCA7, ZNF492, ZDHHC22, and SFRP2. Moreover, a logistic model (CombinedScore) was established based on these DEGs, showing an excellent prediction performance for liver cancer immunotherapy. Patients with a low CombinedScore might respond better to immunotherapy. Gene Set Enrichment Analysis showed that many metabolism pathways were activated in patients with a high CombinedScore, including butanoate metabolism, bile acid metabolism, fatty acid metabolism, glycine serine and threonine metabolism, and propanoate metabolism. Our comprehensive analysis showed that the CombinedScore was negatively correlated with the levels of most tumor-infiltrating immune cells and the activities of key steps of cancer immunity cycles. Continually, the CombinedScore was negatively associated with the expression of most immune checkpoints and immunotherapy response-related pathways. Moreover, patients with a high and a low CombinedScore exhibited diverse genomic features. Furthermore, we found that CDCA7 was significantly correlated with patient survival. Further analysis showed that CDCA7 was positively associated with M0 macrophages and negatively associated with M2 macrophages, suggesting that CDCA7 could influence the progression of liver cancer cells by affecting macrophage polarization. Next, single-cell analysis showed that CDCA7 was mainly expressed in prolif T cells. Immunohistochemical results confirmed that the staining intensity of CDCA7 was prominently increased in the nucleus in primary liver cancer tissues compared to adjacent non-tumor tissues.

Conclusions

Our results provide novel insights into the DEGs and factors affecting liver cancer immunotherapy. Meanwhile, CDCA7 was identified as a potential therapeutic target in this patient population.
Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years
Authors: Santana Carolina Souza , Andrade Felipe de Oliveira , da Silva Greice Carolina Santos , Nascimento Jéssica Oliveira de Souza , Campos Raissa Frazão , Giovanetti Marta , Santos Luciane Amorim , Gois Luana Leandro , Alcantara Luiz Carlos Júnior , Barreto Fernanda Khouri
Published: February 2023

Introduction

The Human T-lymphotropic virus type 1 (HTLV-1) was the first described human retrovirus. It is currently estimated that around 5 to 10 million people worldwide are infected with this virus. Despite its high prevalence, there is still no preventive vaccine against the HTLV-1 infection. It is known that vaccine development and large-scale immunization play an important role in global public health. To understand the advances in this field we performed a systematic review regarding the current progress in the development of a preventive vaccine against the HTLV-1 infection.

Methods

This review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA®) guidelines and was registered at the International Prospective Register of Systematic Reviews (PROSPERO). The search for articles was performed in PubMed, Lilacs, Embase and SciELO databases. From the 2,485 articles identified, 25 were selected according to the inclusion and exclusion criteria.

Results

The analysis of these articles indicated that potential vaccine designs in development are available, although there is still a paucity of studies in the human clinical trial phase.

Discussion

Although HTLV-1 was discovered almost 40 years ago, it remains a great challenge and a worldwide neglected threat. The scarcity of funding contributes decisively to the inconclusiveness of the vaccine development. The data summarized here intends to highlight the necessity to improve the current knowledge of this neglected retrovirus, encouraging for more studies on vaccine development aiming the to eliminate this human threat.

Systematic review registration

https://www.crd.york.ac.uk/prospero, identifier (CRD42021270412).
Identification of shared gene signatures and molecular mechanisms between chronic kidney disease and ulcerative colitis
Authors: Liang Zhou , Hu Xinrong , Lin Ruoni , Tang Ziwen , Ye Ziyin , Mao Ren , Chen Wei , Zhou Yi
Published: February 2023

Background

There is a complex interaction between chronic kidney disease (CKD) and ulcerative colitis (UC), but the pathophysiological mechanisms underlying the coexistence of CKD and UC are unclear. This study aimed to investigate the key molecules and pathways that may mediate the co-occurrence of CKD and UC through quantitative bioinformatics analysis based on a public RNA-sequencing database.

Methods

The discovery datasets of CKD (GSE66494) and UC (GSE4183), as well as validation datasets of CKD (GSE115857) and UC (GSE10616), were downloaded from the Gene Expression Omnibus (GEO) database. After identifying differentially expressed genes (DEGs) with GEO2R online tool, the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses for the DEGs were performed. Next, protein-protein interaction network was constructed with Search Tool for the Retrieval of Interacting Genes (STRING) and visualized by Cytoscape. Gene modules were identified by the plug-in MCODE and hub genes were screened using the plug-in CytoHubba. Then, correlation between immune cell infiltration and hub genes was analyzed, and the receiver operating characteristic curves were used to assess the predictive value of hub genes. Finally, immunostaining of human specimens was used to validate the relevant findings.

Results

A total of 462 common DEGs were identified and selected for further analyses. GO and KEGG enrichment analyses indicated that these DEGs were primarily enriched in immune- and inflammation-related pathways. Among them, the PI3K-Akt signaling pathway ranked top in both discovery and validation cohorts, and the key signal molecule phosphorylated Akt (p-Akt) was shown to be significantly overexpressed in human CKD kidneys and UC colons, and further elevated in CKD-UC comorbidity specimens. Moreover, nine candidate hub genes, including CXCL8, CCL2, CD44, ICAM1, IL1A, CXCR2, PTPRC, ITGAX, and CSF3, were identified, of which ICAM1 was validated as a common hub gene. Besides, immune infiltration analysis revealed that neutrophils, macrophages, and CD4+ T memory cells significantly accumulated in both diseases, and ICAM1 was remarkably associated with neutrophil infiltration. Furthermore, intercellular adhesion molecule1 (ICAM1)-mediated neutrophil infiltration was validated to be upregulated in kidney and colon biopsies of CKD and UC patients, and further increased in patients diagnosed with both CKD and UC. Finally, ICAM1 had shown critical value as a diagnostic marker for the co-occurrence of CKD and UC.

Conclusions

Our study elucidated that immune response, PI3K-Akt signaling pathway, and ICAM1-mediated neutrophil infiltration might be the common pathogenesis of CKD and UC, and identified ICAM1 as a key potential biomarker and therapeutic target for the comorbidity of these two diseases.