bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comprehensive Review on Barrelene-Derived α-Diimine Nickel and Palladium Olefin Polymerization Catalysts
Authors: Zhou Haotian , Feng Chunyu , Zheng Handou , Tu Guangshui , Xiao Xieyi , Gao Haiyang
Published: January 2025

Late transition metal olefin polymerization catalysts have received more attention in the field of catalytic olefin polymerization. Barrelene-based α-diimine nickel and palladium olefin polymerization catalysts are rising stars because of their backbone structure and catalytic properties. In this review, we present a comprehensive review of barrelene-derived α-diimine nickel and palladium olefin polymerization catalysts. α-Diimine nickel and palladium catalysts are introduced from two aspects: barrelene-derived backbone and aniline derivatives with different substituents. The relationship between catalyst structure and catalytic properties is also emphasized. This review attempts to provide an inspiration for the design of high-performance barrelene-based catalysts.
Emotional Contagion Among Adolescents with Type 1 Diabetes Mellitus (T1DM) and Their Primary Caregivers: Benefits of Psychological Support for Family Systems in Pilot Study
Authors: Rodríguez-Rubio Pilar , Martín-Ávila Javier , Rodríguez-Jiménez Esther , Valero-Moreno Selene , Montoya-Castilla Inmaculada , Pérez-Marín Marián
Published: January 2025

Background. T1DM is a significant chronic condition that necessitates regular medical monitoring, dietary and physical activity supervision, and daily blood glucose monitoring and insulin therapy. The management of this disease and the transition to adolescence often have a significant psychosocial impact on the individual and their family. Objective. The objective of this correlational study was to examine the reciprocal influence between adolescents and their caregivers, with a particular focus on the beneficial effect of receiving psychological support sessions from family members and adolescents with T1DM in a pilot study. Methods. An indicator variable was developed to facilitate an analysis of changes occurring prior to, as well as following, the administration of the treatment in question. Family caregivers received two therapy sessions, and we analyzed their perceived caregiver stress. Adolescents had five sessions, and the reduction in emotional distress was studied in them. Results. The sample comprised 15 adolescent–family caregiver dyads. All parents were mothers of adolescents, with a mean age of 47.67 and 13.47 years, respectively. Descriptive statistics and Spearman correlations were conducted. Following the completion of the psychological counseling sessions, the data revealed a significant positive correlation between the perceived reduction in global stress experienced by the caregiver and the adolescent’s emotional distress, with correlation coefficients of 0.74 and 0.61, respectively. Furthermore, a positive relationship was observed between the reduction in existing difficulties in family role adjustment and the reduction in emotional distress among diabetic youth, with correlation coefficients of 0.72 and 0.57. The frequency of emotional distress of the caregiver also correlated with adolescent emotional distress, with a coefficient of 0.60. Conclusions. The findings of this study provide evidence for the circularity of family systems change. A positive emotional contagion effect is observed in the improvements in stress and emotional distress experienced during adolescence and in the family’s adjustment to T1DM, as reported by caregivers and their children who received psychological support sessions.
Clinical Outcomes in Patients with Cystic Fibrosis Receiving CFTR Modulators: A Comparison of Childhood Versus Adolescent Initiation
Authors: Toraih Eman A. , Malik Hassan A. , Islam Rahib K. , Pirzadah Humza A. , Abdelmaksoud Ahmed , Elshazli Rami M. , Boasiako Paul Antwi , Alenazi Shehab Ahmed , Dabel Angelique , Jishu Jessan A. , Alenezi Bandar T. , Aiash Hani , Fawzy Manal S.
Published: January 2025

Background/objectives: Cystic fibrosis (CF) is a life-limiting genetic disorder affecting multiple organ systems. This study compared clinical outcomes, hospitalization rates, and survival between children and adolescents with CF who received CFTR modulator therapies (ivacaftor, lumacaftor, tezacaftor, and elexacaftor). Methods: A retrospective cohort study was conducted using data from the TriNetX global collaborative network. Patients with CF aged 2–12 years (children) and 13–18 years (adolescents) who received CFTR modulator therapies were included. The propensity score matching balanced baseline characteristics between the two age groups. Results: After propensity score matching, 946 patients per group were analyzed. The incidence of respiratory failure (3.81% vs. 1.06%, p < 0.001) and respiratory infections (62.7% vs. 57.5%, p = 0.021) were significantly higher in adolescents compared to children. Adolescents had a higher risk of respiratory failure (HR = 3.6, 95% CI = 1.79–7.21, p < 0.001) and respiratory infections (HR = 1.09, 95% CI = 1.01–1.17, p < 0.001). Adolescents also had a higher hospitalization rate (29.6% vs. 20.3%, p < 0.001), with a 47% higher risk (HR = 1.47, 95% CI = 1.22–1.77, p = 0.001), more hospital visits per person (8.8 vs. 3.7, p = 0.004), and longer hospital stays (32.7 vs. 20.4 days, p = 0.006). Mortality rates were similar between the groups (1.58% vs. 1.26%, p = 0.56). Conclusions: CF patients who initiated CFTR modulator therapies during adolescence had a higher incidence of respiratory failure, respiratory infections, hospitalization rates, and healthcare resource utilization compared to those who started therapy in childhood, despite similar mortality rates. These findings highlight the importance of the early initiation of CFTR modulator therapies.
Effect of Size Asymmetry of Latex Nanoparticles on Formation and Properties of Nanocolloidal Gels
Authors: Morozova Sofia M. , Statsenko Tatiana G.
Published: January 2025

The study of the fundamental principles of gelation of colloidal nanoparticles (NPs) advances the understanding of the formation of colloidal systems of living organisms. In this paper, the effect of particle size for a binary system of oppositely charged latexes on the experimental parameters of the system, including the gelation region, rheological parameters and cluster size, is considered for the first time. It is shown that the gelation regions in the phase diagrams for asymmetric particles are symmetric with respect to the ratio of charge and surface area of the particles. It was found that asymmetric particles form denser gels compared with the same concentration of symmetrical particles. This work provides insight into the gelation of asymmetric NPs, which is important for numerous applications, including their utilization in colloidal gels as ink for additive manufacturing and as scaffolds for cell growth, as well as understanding the fundamental aspects of the formation of bio-colloids.
On Advances of Anonymous Credentials—From Traditional to Post-Quantum
Authors: Chathurangi Madusha , Li Qinyi , Foo Ernest
Published: January 2025

Anonymous credential (AC) systems are privacy-preserving authentication mech-anisms that allow users to prove that they have valid credentials anonymously. These systems provide a powerful tool for several practical applications, such as anonymous pay-ment systems in e-commerce, preserving robust privacy protection for users. Most existing AC systems are constructed using traditional number-theoretic approaches, making them insecure under quantum attacks. With four decades of research in anonymous credential systems, there is a need for a comprehensive review that identifies the design structures of AC systems, organizes the research trends, and highlights unaddressed gaps for the future development of AC, especially bringing AC to post-quantum cryptography. This work is a complete study describing AC systems, as well as their architecture, components, security, and performance. Additionally, real-world implementations of various applications are identified, analyzed, and compared according to the design structure. Lastly, the challenges hindering the shift toward the quantumly secure lattice-based AC designs are discussed.
Comparing Perspectives on Traditional and Complementary Medicine Use in Oncology: Insights from Healthcare Professionals and Oncology Patients in Western Mexico
Authors: Hernandez-Fuentes Gustavo A. , Gómez-Bueno Juan de D. , Pérez-Santos Verónica M. , Valle-Capitaine Imri J. , Villaseñor-Gonzalez Paula M. , Hernández-Zamorano Cristopher J. , Silva-Vázquez César G. , Cruz-Ruiz Miriam de la , Diaz-Martinez Janet , Garza-Veloz Idalia , Rodriguez-Sanchez Iram P. , Martinez-Fierro Margarita L. , Guzmán-Esquivel José , Rojas-Larios Fabian , Delgado-Enciso Ivan
Published: January 2025

Traditional and complementary medicine (T&CM) plays a significant role in healthcare practices among healthcare professionals and oncology patients in Mexico, reflecting its cultural importance. This study aimed to analyze the prevalence, frequency, and factors associated with T&CM use in these two groups, highlighting the differences in practices and perceptions. A total of 382 individuals participated, including 152 healthcare professionals and 230 oncology patients. The findings revealed that while T&CM use was similarly prevalent among healthcare professionals (85.7%) and oncology patients (90.8%), frequent use (≥2 times per week) was significantly higher among patients (46.3%) compared to healthcare professionals (19.1%, p < 0.001). Healthcare professionals showed a preference for non-conventional nutritional interventions (32.5%) and yoga (14.6%) while oncology patients favored plant-based remedies (73.6%) and the consumption of exotic animals and venoms (4.8%). Females were more likely to use T&CM across both groups, with a stronger association among healthcare professionals (AdOR 3.695, 95% CI 1.8–7.4). Oncology patients were less likely to understand T&CM concepts and were more commonly associated with lower socioeconomic status and educational attainment. These findings underscore the importance of considering cultural and demographic factors when integrating T&CM into conventional medical care, especially in regions where T&CM remains widely practiced and trusted.
Data on Stark Broadening of Sn II Spectral Lines
Authors: Dimitrijević Milan S. , Christova Magdalena D. , Yubero Cristina , Sahal-Bréchot Sylvie
Published: January 2025

Data on spectral line widths and shifts broadened by interactions with charged particles, for 44 lines in the spectrum of ionized tin, for collisions with electrons and H II and HeII ions, are presented as online available tables. We obtained them by employing the semiclassical perturbation theory for temperatures, T, within the 5000–100,000 K range, and for a grid of perturber densities from 1014 cm−3 to 1020 cm−3. The presented Stark broadening data are of interest for the analysis and synthesis of ionized tin lines in the spectra of hot and dense stars, such as, for example, for white dwarfs and hot subwarfs, and for the modelling of their atmospheres. They are also useful for the diagnostics of laser-induced plasmas for high-order harmonics generation in ablated materials.
Why Uncertainty Is Essential for Consciousness: Local Prospect Theory vs. Predictive Processing
Authors: Heylighen Francis , Beigi Shima
Published: January 2025

We present and develop local prospect theory (LPT), a novel framework for understanding consciousness, and, in particular, subjective experience and free will. While predictive processing (PP) theories model the brain as trying to optimize the accuracy of predictions, LPT sees uncertainty as an essential feature of conscious decision-making. This is achieved by creating a “local prospect”—a range of potential developments colored by subjective experience from which an agent can freely choose how to react. Drawing on global workspace theory, LPT conceptualizes consciousness as a self-maintaining process of circulating neural activation, creating a temporary working memory where thoughts and feelings coming from different brain modules enter into an asynchronous, non-linear interaction. This contrasts with unconscious processes, which operate automatically and deterministically. LPT proposes entropy-based measures, including the determination of actions by conditions and the breadth of prospect, to quantify the range of potential developments considered. This framework allows us to understand Buddhist practices and concepts, such as mindfulness, liberation from attachments, and meditation, which broaden consciousness and de-automatize reactions by reducing the influence of conditioning. The proposed prospect measure may be operationalized by indicators such as the variety of action, breadth of perception, and unpredictability of behavior, thus allowing for the empirical testing of the theory.
Pre-Service Teachers’ Digital Competence: A Call for Action
Authors: Dolezal Dominik , Motschnig Renate , Ambros Roland
Published: January 2025

In our digital era, pre-service teachers need profound professional digital competences to be able to effectively foster their learners’ digital skills. Studies pointing to a lack of integration of digital competences at secondary schools demonstrate the need for research and action to foster professional digital skills in teacher education. Using a mixed methods approach and based on the DigCompEdu framework, this paper presents the results of a survey comprising 75 questions about students’ capability to teach digital skills, which was answered by 322 advanced pre-service teachers of a large mid-European university. The results of the performed statistical tests and the conducted thematic analysis show that half of the pre-service teachers do not feel sufficiently prepared by their study program to foster digital competence. Students who do not study a STEM subject and students with teaching practice felt significantly less prepared to teach digital skills compared to students who study at least one STEM subject and students without teaching practice, respectively. We conclude that universities should develop and thoughtfully implement a holistic concept to integrate digital skills in the teacher education curriculum to adequately prepare future teachers for the digital era.
Dynamic to Static Model Comparison and Hybrid Metaheuristic Optimization in Induction Motor Parameter Estimation
Authors: Santana Nelson H. B. , Yahyaoui Imene , Oliveira Flavio D. C. , Amorim Arthur E. A. , Simonetti Domingos S. L. , Rocha Helder R. O.
Published: January 2025

This paper presents a comprehensive study of parameter estimation for three-phase induction motors (IMs) using hybrid optimization methods and a comparative evaluation of static and dynamic modeling approaches. A hybrid metaheuristic combining the Sine Cosine Algorithm (SCA) and Particle Swarm Optimization (PSO) is developed to identify optimal motor parameters efficiently. The approach utilizes a static model for rapid estimation, with final parameter values validated against a dynamic model to ensure accuracy in operational predictions. Results confirm that the static model provides robust parameter estimates for key performance metrics, including torque, power factor, and current, aligning well with experimental results from real-motor no-load tests. Parameters estimated by the proposed method demonstrate a high adherence with the motor real measurements. Comparisons also reveal the limitations of static models in scenarios requiring state-space accuracy, such as observer-based control applications. This study concludes by recommending further exploration of alternative motor modeling structures and the hybrid optimization algorithm for parameter estimation.
Development of Energy Demand Profile Based on Non-Historical and Non-Energy Variables: A Headquarters’ Offices Case Study
Authors: Cruz Juliana , Lasierra Isabel , Rqiq Yassine , Ballestín Víctor
Published: January 2025

Under the Positive Energy Districts framework, cities authorities must be informed of the energy demand of districts to design tailor-made policies and strategies to promote the deployment of energy efficiency, sharing and transition actions. However, the diverse data sources and long procedures to collect data because of privacy permissions may result in a slow-down of the development of these roadmaps. To overcome these challenges, this paper is the outcome of the methodology developed under the UP2030 Project designed to estimate the energy demand and energy profile consumptions within urban areas to contribute to the stakeholders involved in decision making processes to inform them about the savings potential related with the use of energy in geographically delimitated areas. The methodology was validated in CIRCE’s headquarters, where the yearly energy estimation consumption is about 98% of the real energy consumed. The main finding of this study is obtaining a model that can estimate the energy usage for occupants’ comfort with minimal data required from the citizens’ side, which will allow stakeholders to consider global energy estimations at the district level in a fast and reliable way to design strategies in a timely manner as required by the energy transition and efficiency standards proposed by the European Union.
Research and Analysis of Explosion-Proof Diesel Engine Performance Based on Different Exhaust Gas Cooling Systems
Authors: Shi Zhiyuan , Wei Hongxin , Li Guanghui , Wang Yuan , Li Quanming , Zheng Xin , Song Kunhao , Chen Chong , Ma Chi , Mozumder Samsil Arefin , Basher Md Khairul
Published: January 2025

As stringent emission regulations and safety standards for explosion-proof diesel engines become more critical, the demand for efficient exhaust cooling systems has increased. Traditional cooling systems, typically relying on cooling and purification water tanks, have limitations in terms of safety, performance, and emissions control. To address these challenges, a novel dry exhaust gas cooling system was developed, incorporating a heat exchanger and exhaust dilution cooling device, replacing the conventional water-based cooling systems. This study explores the performance of the dry exhaust gas cooling system through a series of experiments including explosion-proof testing of the exhaust system, whole machine explosion-proof testing, exhaust temperature measurements, surface temperature evaluations, and exhaust gas composition analysis. The system’s performance was compared to both wet and combined dry + wet exhaust gas cooling systems. Results showed that the dry exhaust cooling system maintained its explosion-proof integrity during all tests, with the highest exhaust temperature at 68.5 °C and a surface temperature of 130.8 °C—both of which comply with safety standards. Notably, the dry exhaust system also demonstrated improved power output and reduced fuel consumption by over 4% compared to the other systems. Furthermore, it significantly lowered harmful exhaust emissions, reducing CO, HC, NOX, and CO2 levels by 55%, 71%, 68%, and 82%, respectively, when compared to the wet exhaust cooling system. In comparison to the dry + wet system, these reductions were even more pronounced—63%, 75%, 66%, and 94%, respectively. The findings suggest that the dry exhaust gas cooling system offers a safer, more efficient, and environmentally friendly alternative to conventional exhaust cooling systems in explosion-proof diesel engines.
Fermentation of Whole-Wheat Using Different Combinations of Lactic Acid Bacteria and Yeast: Impact on In Vitro and Ex Vivo Antioxidant Activity
Authors: Tomassi Elena , Arouna Nafiou , Brasca Milena , Silvetti Tiziana , de Pascale Sabrina , Troise Antonio Dario , Scaloni Andrea , Pucci Laura
Published: January 2025

Cereals are rich in nutrients and bioactive compounds; however, many of these, such as polyphenols, are bound to the cell wall matrix, limiting their bioavailability. This study investigated the use of fermentation to enhance the bioavailability of functional compounds in whole-wheat flour. Given the impact of microbial species on fermentation outcomes, various combinations of lactic acid bacteria and yeast strains were examined. The polyphenol and flavonoid content of different fermented flours was analyzed. Additionally, the antioxidant capacity was assessed using in vitro assays (DPPH, ORAC, and FRAP) and an ex vivo test with human erythrocytes. Fermentation significantly enhanced the release of bioavailable phenolic compounds and flavonoids, with the most significant increases reaching up to 3.4-fold and 2.64-fold, respectively. In particular, the findings highlight the capacity of flour fermented with a combination of K. humilis, F. sanfranciscensis, E. faecium, P. pentosaceus, and L. mesenteroides to enhance antioxidant activity in vitro and to protect human red blood cells from oxidative stress. Furthermore, fermentation increased the production of short-chain fatty acids, notably lactate and acetate, which are widely recognized for their gut health benefits. Overall, this study highlights the effectiveness of targeted fermentation in improving the bioactivity and antioxidant properties of whole-wheat flour.
Baijiu–Peanut Pairing In Vitro and In Vivo: The Decreased but Prolonged Aftertaste of Baijiu Under the Effect of Mouth Coating Formed by Peanut Lipid
Authors: Chen Lu , Sun Jinyuan , Zhang Yanyan , Li Hehe , Zhao Dongrui , Wang Bowen , Ye Xingqian , Sun Baoguo
Published: January 2025

Baijiu–peanut pairing is a popular food combination, wherein peanuts, particularly their lipid component, possess the potential to influence the flavor of baijiu and consequently modulate its aftertaste. To reveal the role of peanut lipid within this system, headspace experiments and equilibrium constant measurements were conducted. It was determined that peanut lipids are capable of inhibiting the release of flavor substances in baijiu, and this inhibitory effect is concentration-dependent. Molecular dynamics simulation results show a strong interaction between peanut lipids and ethanol (E binding = −2.181 kJ/mol), which weakens the binding energy between ethanol and compounds, resulting in 1 + 1 < 2 effect. The Intraoral SPME experiment revealed the retention effect lipid-coating on the aroma release of baijiu. The flavor substances retained in the oral coating can continuously contribute to the aftertaste perception of baijiu. Peanut lipids, leveraging the Marangoni effect of ethanol, play a role in prolonging the aftertaste of baijiu, either through direct or indirect ways. This study provides a scientific basis for understanding the complex flavor experience in the food pairing process.
Criterion of the Existence of a Strongly Continuous Resolving Family for a Fractional Differential Equation with the Hilfer Derivative
Authors: Fedorov Vladimir E. , Du Wei-Shih , Kostić Marko , Plekhanova Marina V. , Skorynin Anton S.
Published: January 2025

In the qualitative theory of differential equations in Banach spaces, the resolving families of operators of such equations play an important role. We obtained necessary and sufficient conditions for the existence of strongly continuous resolving families of operators for a linear homogeneous equation resolved with respect to the Hilfer derivative. These conditions have the form of estimates on derivatives of the resolvent of a linear closed operator from the equation and generalize the Hille–Yosida conditions for infinitesimal generators of C0-semigroups of operators. Unique solvability theorems are proved for the corresponding inhomogeneous equations. Illustrative examples of the operators from the considered classes are constructed.
Mechanical Response of Mudstone Based on Acoustic Emission Fractal Features
Authors: Chang Xianyin , Liang Yunpei , Ran Qican
Published: January 2025

In this study, the effect of the stress amplitude on the mechanical behavior of mudstone was systematically investigated by cyclic loading and unloading experiments and acoustic emission (AE) monitoring. The results show that at low-stress amplitudes, mudstone specimens show better elastic recovery ability, lower damage accumulation and higher structural stability. At high-stress amplitudes, the irreversible damage of the mudstone increases significantly, the internal fractures gradually expand and penetrate through, and the risk of instability increases significantly. This is manifested by the gradual increase in cumulative irreversible strain of mudstone at different stress amplitudes, up to 0.144%. In addition, different stress amplitudes have significant effects on energy evolution characteristics, with low-stress amplitudes mainly showing elastic deformation and a high percentage of recoverable energy, while high-stress amplitudes show a high percentage of dissipated energy. Under the condition of high-stress amplitude, such as the mudstone specimen #4, the percentage of tensile failure is 81.15%. Tensile failure dominates at all stress amplitudes, where the failure mechanism within mudstone is mainly characterized by the extension of tensile-type fractures. Through the multifractal analysis of AE signals, this study reveals the effect of the stress amplitude on the fracture extension mode and failure mechanism of mudstone. As the stress amplitude increases, Δα and Δf show an increasing trend. This indicates that the fracture extension process transforms from a relatively homogeneous and simple mode to a more inhomogeneous and complex mode. This transformation reflects the nonlinear and multiscale fracture characteristics of mudstone under high-stress conditions. The results of this study help to understand the mechanical behavior of mudstone under cyclic loading during coal mining and provide theoretical support for safe coal production.
The Synthesis and Spectroscopic Characterization of Structural Changes in Hydrophobic Silica Aerogels upon Encapsulation of the LCC ICCG Enzyme
Authors: Alpízar-Rojas Tatiana , Barboza-Carmona Juan Diego , Butenschön Erik , Musabirova Guzel , Castellón Erick , Matysik Jörg , Céspedes-Camacho Isaac F.
Published: January 2025

Silica aerogels are highly porous materials known for their low density and extensive surface area, making them ideal for applications in thermal insulation, catalysis, and environmental remediation. This study investigates the structural changes of functionalized hydrophobic silica aerogels used as carriers of the LCC ICCG enzyme. The aerogels were synthesized using the sol-gel method, with trimethylethoxysilane (TMES) as a functionalizing agent to enhance hydrophobicity. The enzyme-encapsulated aerogels were characterized using hyperpolarized 129Xe NMR, 29Si NMR, nitrogen sorption analysis, TEM, contact angle measurements, and FT-IR spectroscopy to evaluate their structural and chemical properties. The results confirmed successful encapsulation of the enzyme, as indicated by changes in the pore structure and network morphology. These findings demonstrate that functionalized silica aerogels can effectively support LCC ICCG immobilization, offering a promising approach for plastic degradation applications.
Enzymatically Cross-Linked Hydrogel Beads Based on a Novel Poly(aspartamide) Derivative
Authors: Hou Wenzhuo , Yi Hui , Zhang Guangyan
Published: January 2025

In recent years, hydrogel beads and in situ hydrogels have gained wide attention in various fields such as biomedicine. In this study, 3-(4-hydroxyphenyl) propionic acid (HP) was introduced into the side chain of poly(α,β-[N-(2-hydroxyethyl)-D,L-aspartamide]) (PHEA) to synthesize phenolic hydroxyl-functionalized poly(aspartamide) derivative PHEA-HP with enzyme-catalyzed cross-linking potential. First, the chemical structure of PHEA-HP was characterized by FT-IR, UV and 1H NMR, and the results of in vitro cytotoxicity against L929 cell line and hemolysis experiment showed that PHEA-HP did not have toxicity to cells (viability > 90%) and had good blood compatibility. Then, rheological measurement confirmed the formation of PHEA-HP-based in situ hydrogel with a high storage modulus (G′) around 104 Pa, and the vial-tilting method revealed that the gelation time of PHEA-HP aqueous solution could be tuned in the wide range of 5–260 s by varying the concentrations of hydrogen peroxide (H2O2) and horseradish peroxidase (HRP). Finally, hydrogel beads of different diameters containing methylene blue (for easy observation) were prepared using a coaxial needle and syringe pumps, and the effect of the flow rate of the outer phase on the diameters of the hydrogel beads was also investigated. Therefore, PHEA-HP may be a promising and safe poly(aspartamide) derivative that can be used to prepare in situ hydrogels and hydrogel beads for applications closely related to the human body.
Editorial for the Special Issue: Bioinformatics and Computational Biology for Cancer Prediction and Prognosis
Authors: Dancik Garrett M. , Vlahopoulos Spiros A.
Published: January 2025

Cancer is a global health concern, with approximately 20 million new cancer cases diagnosed worldwide each year [...]
A Trans and Queer Discursive Approach to Gender Diversity and Misgendering in the Transgender and Gender Diverse Population: Queering a Study for ICD-11
Authors: Baleige Anna , Denis Frédéric
Published: January 2025

Producing knowledge about transgender and gender-diverse (TGD) individuals is a core public health strategy challenge. Yet several systemic limitations arise, notably the exclusion or exploitation of TGD individuals by research systems reproducing systemic discrimination by embedding social norms as self-evident facts of nature. This is particularly worrying in biomedical research, and contributes to the invisibilization of participants’ gender diversity. This trans research illustrates methodological challenges through queering an earlier study by focusing on misgendering as a discursive element. We based our work on discursive materials reported by TGD participants in an ICD-11 study on gender incongruence. We used network analyses to illustrate potential differences between declared gender identity and discourse practices. Our results highlight a gap between declared gender identity and discourse practices, bringing the number of non-binary participants in the sample from 15 (20.8%) to 36 (50.0%). Moreover, misgendering and the use of derogatory terms are more common toward gender-diverse individuals. Sexual orientation shows a similar trend. This study reveals the reproduction of social norms within research processes and medical knowledge, as well as how, from an individual perspective, their non-compliance seems to be a key factor in TGD individuals’ experience. By providing this simple methodological example, we hope to promote better integration of gender and its various dimensions into biomedical and public health research.
Groundwater Contamination: Study on the Distribution and Mobility of Metals and Metalloids in Soil and Rocks
Authors: Lo Medico Federica , Rizzo Pietro , Rotigliano Edoardo , Celico Fulvio
Published: January 2025

This study investigates the distribution and mobility of metals and metalloids (M&Ms) in soils, rocks, and groundwater within the geologically complex southwestern region of Sicily. The study aims to highlight how natural sources, like rocks and soils, can release elements potentially harmful to human health. It underlines their dual role as both natural reservoirs and active sources of M&M release, driven by leaching processes influenced by physicochemical factors such as pH and redox potential (Eh). Lithological characteristics significantly influence the retention and release of elements, with clay-rich formations exhibiting higher immobilization capacity. However, environmental parameter variations can enhance element mobilization, increasing bioavailability and the risk of groundwater contamination. Water quality analyses reveal regulatory exceedances for As, B, Ni, and Be, underscoring potential health and ecological risks. Concurrently, microbiological investigations identify diverse microbial communities capable of altering the oxidative states of specific elements through oxidation and reduction processes, further influencing their mobility. This study underscores the importance of understanding natural sources of M&Ms and their interactions with geochemical and microbiological processes for effective environmental risk assessment. The findings provide a foundation for developing integrated and sustainable water resource management strategies to mitigate contamination risks and safeguard ecosystems and public health.
Farnesoid X Receptor Attenuates the Tumorigenicity of Liver Cancer Stem Cells by Inhibiting STAT3 Phosphorylation
Authors: Ye Wenling , Zhao Yang , Wang Yibo , Wang Yahan , Zhang Huan , Wang Fengling , Chen Weidong
Published: January 2025

The Farnesoid X receptor (FXR) has recently been identified as being closely associated with the progression of primary hepatocellular carcinoma. Cancer stem cells (CSCs) play a crucial role in tumor initiation, progression, invasion, metastasis, recurrence, and drug resistance. The elucidation of the role and regulatory mechanism of FXR in CSCs is therefore deemed significant. Here, bioinformatics analysis has revealed a downregulation of FXR in hepatocellular carcinoma (HCC), which showed a negative correlation with HCC malignancy. This result was further confirmed through clinical sample analysis. Subsequently, CSCs were isolated from HCC cell lines and exhibited a significant decrease in the expression of FXR. The activation of FXR resulted in a remarkable inhibition of the proliferation, invasion, and tumorigenicity of CSCs. Furthermore, activated FXR prominently upregulated the expression of SOCS3 while suppressing STAT3 phosphorylation in CSCs. To further investigate this discovery, we established a DEN-induced HCC model in mice and observed that FXR-deficient mice exhibited heightened susceptibility to HCC. This was accompanied by decreased expression levels of SOCS3 and elevated expression and phosphorylation levels of STAT3, as well as significantly enhanced HCC CSCs markers and stemness-related genes expression in DEN-induced HCC tissues of FXR-deficient mice. Additionally, we also found a significant upregulation of CSCs markers and stemness-related genes within HCC clinical samples. Based on these findings, we postulated that targeted regulation of SOCS3 by FXR inhibits STAT3 phosphorylation, thereby exerting an inhibitory effect on CSCs.
Relevance of Lipoprotein Composition in Endothelial Dysfunction and the Development of Hypertension
Authors: Ramírez-Melo Lisette Monsibaez , Estrada-Luna Diego , Rubio-Ruiz María Esther , Castañeda-Ovando Araceli , Fernández-Martínez Eduardo , Jiménez-Osorio Angélica Saraí , Pérez-Méndez Óscar , Carreón-Torres Elizabeth
Published: January 2025

Endothelial dysfunction and chronic inflammation are determining factors in the development and progression of chronic degenerative diseases, such as hypertension and atherosclerosis. Among the shared pathophysiological characteristics of these two diseases is a metabolic disorder of lipids and lipoproteins. Therefore, the contents and quality of the lipids and proteins of lipoproteins become the targets of therapeutic objective. One of the stages of lipoprotein formation occurs through the incorporation of dietary lipids by enterocytes into the chylomicrons. Consequently, the composition, structure, and especially the properties of lipoproteins could be modified through the intake of bioactive compounds. The objective of this review is to describe the roles of the different lipid and protein components of lipoproteins and their receptors in endothelial dysfunction and the development of hypertension. In addition, we review the use of some non-pharmacological treatments that could improve endothelial function and/or prevent endothelial damage. The reviewed information contributes to the understanding of lipoproteins as vehicles of regulatory factors involved in the modulation of inflammatory and hemostatic processes, the attenuation of oxidative stress, and the neutralization of toxins, rather than only cholesterol and phospholipid transporters. For this review, a bibliographic search was carried out in different online metabases.
Plant Biostimulants to Enhance Abiotic Stress Resilience in Crops
Authors: Di Sario Luciana , Boeri Patricia , Matus José Tomás , Pizzio Gastón A.
Published: January 2025

The escalating impact of abiotic stress on crop productivity requires innovative strategies to ensure sustainable agriculture. This review examines the promising role of biostimulants in mitigating the adverse effects of abiotic stress on crops. Biostimulants, ranging from simple organic compounds to complex living microorganisms, have demonstrated significant potential in enhancing plant resilience, stress tolerance, and overall performance. The mechanisms underlying biostimulant action—such as enhancing antioxidant defenses, regulating hormonal pathways, and inducing metabolic adjustments—are reviewed. Furthermore, we incorporate the latest research findings, methodologies, and advancements in biostimulant applications for addressing abiotic stressors, including drought, salinity, high temperatures, and nutrient deficiencies. This review also highlights current challenges and future opportunities for optimizing biostimulant use in sustainable crop production. This revision aims to guide researchers and agronomists in applying biostimulants to improve crop resilience in the context of climate change.
Comparative Assessment of Acute Pulmonary Effects Induced by Heat-Not-Burn Tobacco Aerosol Inhalation in a Murine Model
Authors: Kim Beong Ki , Yang Won Jin , Seong Ye Seul , Choi Yong Jun , Park Hye Jung , Byun Min Kwang , Chang Yoon Soo , Cho Jae Hwa , Kim Chi Young
Published: January 2025

Tobacco smoking remains a major global health concern, causing preventable deaths and economic strain. Although new tobacco products such as heat-not-burn (HnB) are safer alternatives to traditional cigarettes, research on their associated risks remains limited. This study aimed to investigate the effects of HnB smoke exposure on the lungs compared to those of traditional cigarettes and the combined use of HnB and cigarettes using experiments with a mouse model. We quantitatively analyzed changes in the levels of 92 blood plasma proteins using the proximity extension assay method and observed significant changes in their levels in mice exposed to different smoke conditions; specifically, the levels of certain proteins, including Ccl20, Cxcl1, and Pdgfb, increased in the HnB smoke-exposed group, suggesting activation of nicotine pathways. Comparative analysis with traditional cigarette smoke-exposed mice further highlighted similarities and differences in their protein expression profiles. This study contributes to an improved understanding of the biological mechanisms underlying the harmful effects of alternative nicotine delivery systems and identifies potential biomarkers associated with the harmful effects of HnB smoke exposure. However, the precise impact of nicotine on the immune system may be influenced by various factors, necessitating further research.
Combining Colchicine and Antiplatelet Therapy to Tackle Atherothrombosis: A Paradigm in Transition?
Authors: Giordano Salvatore , Camera Marina , Brambilla Marta , Sarto Gianmarco , Spadafora Luigi , Bernardi Marco , Iaconelli Antonio , D’Amario Domenico , Biondi-Zoccai Giuseppe , Celia Alessandra Ida , Tremoli Elena , Frati Giacomo , Angiolillo Dominick J. , Sciarretta Sebastiano , Galli Mattia
Published: January 2025

Atherothrombosis, the primary driver of acute cardiovascular (CV) events, is characterized by the activation of three key pathophysiological pathways: platelets, coagulation, and inflammation. Dual antiplatelet therapy (DAPT) is the current standard of care for patients with acute coronary syndrome, providing significant reductions in cardiovascular (CV) events, albeit with an associated increased risk of bleeding. However, the high residual risk of recurrent events among these patients highlights the need for alternative strategies to treat and prevent atherothrombosis. To this extent, several approaches aimed at targeting atherothrombosis have been proposed. Among these, a strategy of dual-pathway inhibition simultaneously targeting platelets, using single or DAPT, and coagulation, using a low-dose anticoagulant such as rivaroxaban 2.5 mg twice daily, has shown to reduce CV events but at the expense of increased bleeding. Targeting inflammatory pathways has the potential to be a highly effective strategy to tackle atherothrombosis without increasing bleeding risk. Several anti-inflammatory agents have been tested in patients with coronary artery disease, but to date only colchicine is approved for secondary prevention on top of standard care, including antiplatelet therapy. However, many aspects of colchicine’s mechanism of action, including its antiplatelet effects and how it synergizes with antiplatelet therapy, remain unclear. In this review, we summarize the available clinical and pre-clinical evidence on the antiplatelet effects of colchicine and its synergistic interactions with antiplatelet therapy, highlighting their potential role in addressing atherothrombosis.
TNF/IFN-γ Co-Signaling Induces Differential Cellular Activation in COVID-19 Patients: Implications for Patient Outcomes
Authors: Ramón-Luing Lucero A. , Martínez-Gómez Laura Edith , Martinez-Armenta Carlos , Martínez-Nava Gabriela Angélica , Medina-Quero Karen , Pérez-Rubio Gloria , Falfán-Valencia Ramcés , Buendia-Roldan Ivette , Flores-Gonzalez Julio , Ocaña-Guzmán Ranferi , Selman Moisés , López-Reyes Alberto , Chavez-Galan Leslie
Published: January 2025

TNF and IFN-γ are key proinflammatory cytokines implicated in the pathophysiology of COVID-19. Toll-like receptor (TLR)7 and TLR8 are known to recognize SARS-CoV-2 and induce TNF and IFN-γ production. However, it is unclear whether TNF and IFN-γ levels are altered through TLR-dependent pathways and whether these pathways mediate disease severity during COVID-19. This study aimed to investigate the association between TNF/IFN-γ levels and immune cell activation to understand their role in disease severity better. We enrolled 150 COVID-19 patients, who were classified by their systemic TNF and IFN-γ levels (high (H) or normal–low (N-L)) as TNFHIFNγH, TNFHIFNγN-L, TNFN-LIFNγH, and TNFN-LIFNγN-L. Compared to patients with TNFN-LIFNγN-L, patients with TNFHIFNγH had high systemic levels of pro- and anti-inflammatory cytokines and cytotoxic molecules, and their T cells and monocytes expressed TNF receptor 1 (TNFR1). Patients with TNFHIFNγH presented the SNP rs3853839 to TLR7 and increased levels of MYD88, NFκB, and IRF7 (TLR signaling), FADD, and TRADD (TNFR1 signaling). Moreover, critical patients were observed in the four COVID-19 groups, but patients with TNFHIFNγH or TNFHIFNγN-L most required invasive mechanical ventilation. We concluded that increased TNF/IFN-γ levels are associated with hyperactive immune cells, whereas normal/low levels are associated with hypoactivity, suggesting a model to explain that the pathophysiology of critical COVID-19 may be mediated through different pathways depending on TNF and IFN-γ levels. These findings highlight the potential for exploring the modulation of TNF and IFN-γ as a therapeutic strategy in severe COVID-19.
Charging Method Selection of a Public Charging Station Using an Interval-Valued Picture Fuzzy Bidirectional Projection Based on VIKOR Method with Unknown Attribute Weights
Authors: Shit Chittaranjan , Ghorai Ganesh
Published: January 2025

Excessive use of fossil fuel-powered vehicles is a major problem for the entire world today, because of which greenhouse gases are increasing day by day. As a result, climate change and global warming have grown to be serious problems that affect both the environment and life on Earth. However, the effective way of reducing greenhouse gases is to use electric vehicles for commuting. The assessment and selection of the best possible way of charging an electric vehicle is a convoluted decision-making challenge due to the presence of assorted contradictory criteria. Additionally, individual decision makers’ minds and insufficient data are obstacles to doing this. In this regard, interval-valued picture fuzzy sets have been considered as a compatible tool to handle vagueness. In this paper, a multi-attribute group decision-making problem with the bidirectional projection-based VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR) method is considered where the weights are partially known. The objective weights of the attributes in this model are determined using the deviation-based approach. The compromised solution is also assessed using the VIKOR approach. Both the interval-valued image fuzzy Schweizer–Sklar power weighted geometric operator and the interval-valued picture fuzzy Schweizer–Sklar power weighted averaging operator are used in this process. Lastly, a numerical example showing the most suitable way to charge an electric vehicle is given to demonstrate the suggested methodology. To evaluate the robustness and efficacy of the suggested strategy, a comparative analysis with current techniques and a sensitivity analysis of the parameters are also carried out.
An Agglomerative Clustering Combined with an Unsupervised Feature Selection Approach for Structural Health Monitoring
Authors: Boratto Tales , Bernardino Heder Soares , Vieira Alex Borges , Gontijo Tiago Silveira , Bodini Matteo , Martyushev Dmitriy A. , Saporetti Camila Martins , Cury Alexandre , Barbosa Flávio , Goliatt Leonardo
Published: January 2025

Structural health monitoring (SHM) is critical for ensuring the safety and longevity of structures, yet existing methodologies often face challenges such as high data dimensionality, lack of interpretability, and reliance on extensive label datasets. Current research in SHM has primarily focused on supervised approaches, which require significant manual effort for data labeling and are less adaptable to new environments. Additionally, the large volume of data generated from dynamic structural monitoring campaigns often includes irrelevant or redundant features, further complicating the analysis and reducing computational efficiency. This study addresses these issues by introducing an unsupervised learning approach for SHM, employing an agglomerative clustering model alongside an unsupervised feature selection technique utilizing box-plot statistics. The proposed method is assessed through raw acceleration signals obtained from four dynamic structural monitoring campaigns, including 44 features with temporal, statistical, and spectral information. In addition, these features are also evaluated in terms of their relevance, and the most important ones are selected for a new execution of the computational procedure. The proposed feature selection not only reduces data dimensionality but also enhances model interpretability, improving the clustering performance in terms of homogeneity, completeness, V-measure, and adjusted Rand score. The results obtained for the four analyzed cases provide clear insights into the patterns of behavior and structural anomalies.