bluuebunny/crossref_metadata_2025 huggingface dataset:
Il controllo e la gestione della performance delle attività di prevenzione in contesti interorganizzativi: il caso dei controlli frontalieri sugli alimenti
Authors: Noto Guido , Coletta Lucrezia , Zuccarino Sara , Vainieri Milena
Published: June 2021

I servizi sanitari di prevenzione sono caratterizzati da un'elevata complessita principalmente legata al contesto inter-organizzativo e ambientale in cui operano. Da cio consegue una notevole difficolta nel misurarne e valutarne i risultati. Per tali motivi, il controllo e la gestione della performance delle attivita di prevenzione si avvalgono di diversi meccanismi, formali e informali, che hanno l'obiettivo di orientare i comportamenti e le decisioni degli individui e delle organizzazioni coinvolte verso fini comuni. Lo scopo del presente lavoro e quello di approfondire i sistemi di controllo e gestione della performance impiegati nei servizi di prevenzione che operano in contesti inter-organizzativi - e in particolare nell'ambito dei controlli frontalieri sugli alimenti - al fine di supportare il disegno e l'implementazione degli stessi. Per fare cio, la ricerca si concentra sui casi di studio delle infrastrutture portuali di Genova e Livorno. Parole chiave: prevenzione, controlli condottools. To explore performance management in such contexts, this research suggests the adoption of management control as a "package" approach. Thus, the research's objective is to understand how management control operates in the delivery of preventative services operating in inter-organizational environment. To do so, this study focuses on the cases of Genoa's and Leghorn's ports.
Un modello di performance management per mitigare il problema dell'ambiguità nell'organizzazione della prevenzione collettiva: il caso della Regione Friuli-Venezia Giulia
Authors: Cinquini Lino , Campanale Cristina , Del Bianco Flavio , Oppi Chiara
Published: June 2021

Questo articolo discute come la realizzazione di un sistema di performance management all'interno dei processi dei dipartimenti di prevenzione della Regione Friuli-Venezia Giulia possa ridurre alcune variabili di ambiguita organizzativa. Attraverso un approccio quali-quantitativo basato su action research e survey i ricercatori hanno partecipato alla realizzazione di un sistema che, nell'ambito dei dipartimenti di prevenzione, descrive i processi e le attivita svolte in relazione a specifici target e ne determina il consumo di risorse standard. Inoltre, e stata realizzata un'indagine esplorativa per l'assessment ex ante delle potenzialita del sistema in termini di riduzione di ambiguita, che puo contribuire a fornire input per una revisione del sistema prima della sua implementazione. Questa ricerca presenta i seguenti contributi e implicazioni. Il primo contributo si evidenzia rispetto alla letteratura sull'ambiguita. Il secondo contributo e relativo alla definizione di un approccio per la valutazione ex ante delle potenzialita di un sistema di misurazione delle performance nella mitigazione dell'ambiguita. I risultati hanno implicazioni pratiche per il management sanitario e forniscono spunti di riflessione a supporto dello sviluppo di sistemi di misurazione della performance nella prevenzione collettiva.
Un nuovo paradigma per le scienze e le professioni psicologiche e psichiatriche
Authors: Bastianelli Laura , Bianchi Alessandro , Bottaccioli Francesco , Cardone Raffaella , Romy Cutrona Ines , Palo Gianangelo , Sinibaldi Fabio , Stoppele Emanuela , Tossici Giulia , Vaccaro Laura
Published: June 2021

Proposte della Commissione nazionale Discipline Mentali della Società Italiana di Psiconeuroendocrinoimmunologia (Dis.Men Sipnei) per il rinnovamento delle scienze e delle pratiche psicologiche e psichiatriche. A più di 80 anni dalla morte di Freud, registriamo due fenomeni simultanei: da un lato il profondo ridimensionamento dell'influenza della psichiatria biologica e dall'altro lato la dissoluzione dell'ortodossia in psicologia. Questa doppia crisi ha innescato alcuni cambiamenti rilevanti: ha favorito la convergenza e la contaminazione tra le diverse tradizioni psicologiche e ha fatto crescere la reputazione del professionista "psi" e del lavoro psicologico quale intervento efficace sulla salute umana. Un fenomeno indubbiamente positivo che, tuttavia, presenta un profilo, a giudizio degli autori, negativo: la tendenza ad affidarsi all'empirismo e all'eclettismo clinico, accantonando la riflessione e il dibattito sui nodi della teoria e della prassi psicologica. Per questo gli autori ritengono opportuno e utile avanzare una riflessione di fondo su cui incardinare proposte operative.
La relazione struttura-funzione: le interazioni fra stress, immunità e fascia
Authors: Barsotti Nicola , Chiera Marco , Lanaro Diego
Published: June 2021

La risposta di stress, tramite il rilascio dei glucocorticoidi e delle catecolamine e modificando le risposte endocrine, neurali e immunitarie, può influenzare la struttura corporea, sia a livello tissutale sia a livello cellulare. In particolare, tramite il coinvolgimento del sistema immunitario, la risposta di stress può alterare la struttura della fascia, un tipo di tessuto connettivo presente nell'interno organismo che svolge importanti ruoli architetturali e di comunicazione per tutti gli organi. Nel presente articolo, attraverso una disamina della risposta di stress, del sistema immunitario e del tessuto connettivo, gli autori eseguono una revisione di queste interazioni alla luce della Pnei per evidenziare come struttura e funzioni corporee siano strettamente collegate. Particolare attenzione verrà posta a come fascia, muscoli e ossa risentano della risposta di stress e a come lo stile di vita possa giocare un ruolo determinante in questo equilibrio.
La dipendenza da cocaina: verso un'integrazione delle cure
Authors: Radolovic Doris
Published: June 2021

Le ricerche scientifiche hanno dimostrato che la dipendenza da sostanze è una patologia cronica recidivante ad eziologia multifattoriale, prodotta dall'interconnessione tra la dimensione biologica, psicologica e quella ambientale. La cocaina è la seconda droga illecita più comunemente utilizzata in Europa. Il suo consumo si impone ormai come uno tra i più gravi problemi sociali che gli operatori dei diversi settori si trovano ad affrontare. Comprendere come i diversi fattori coinvolti concorrono a determinare la vulnerabilità all'uso problematico di cocaina rappresenta l'aspetto fondamentale per i futuri progetti di prevenzione e di trattamento di tale patologia. L'integrazione delle cure in questo ambito sembra destinato non solo a modificare l'efficacia del trattamento, ma anche ad aprire nuovi orizzonti di ricerca per quanto riguarda la sua origine e la natura del rapporto che lega funzionalmente tra loro l'aspetto biologico, psicologico e socio-ambientale. Vengono infine esposti alcuni possibili approcci terapeutici nell'ambito della dipendenza da cocaina.
Alfred Binet and the psychology of testimony
Authors: Nicolas Serge
Published: June 2021

In the early 1890s, Alfred Binet (1857-1911) became one of the most famous specialists in the study of human memory. He conducted research on many different aspects of memory and was a pioneer (1) in the study of the influence of suggestions (1894) on memory and the whole question of what would nowadays be called false memory or memory illusions, and (2) in founding the science of testimony (1900) by examining the influence of suggestion on memory but also its distortions. It was first within the framework of his program of individual psychology that Binet engaged in research that would lead to the idea of the foundation of this new field of research. In his book "on suggestibility" (1900), Binet formally established the scientific foundation for a "Science of testimony", studying the effect of suggestibility with images as stimuli. Inspired by Binet's experimental investigations, Stern (1902) had the talent to bring to light this process of natural falsification of memory. He outlined the plan and the limits of the new field of research glimpsed by Binet, he systematized its methods and procedures, he specified the points to be researched, and he finally gave a personal example of how the experiment should be conducted. Stern's work showing that error-free recollection is not the rule but the exception was the starting point of a movement that clearly attracted the world of German psychologists and jurists, and soon psychologists and jurists from various countries.
La testimonianza del minore: riflessioni criminologiche
Authors: Pietralunga Susanna , Salvioli Claudia
Published: June 2021

La testimonianza del minore presenta aspetti di specifica complessità e la letteratura criminologica, psichiatrico-forense e giuridica analizza approfonditamente i compiti dell'esperto sotto il profilo metodologico, clinico ed, altresì, deontologico. Si segnala per la sua complessità la particolare situazione che si crea allorché il minore, non di rado all'interno di un reato di gruppo, riveste il duplice ruolo di testimone e di autore di reato. Anche gli importanti cambiamenti che interessano la cultura sociale e le sollecitazioni che derivano dalla comunicazione multimediale possono facilitare ulteriormente l'intrecciarsi dei ruoli di testimone ed autore di reato. Si pongono in tali contesti problemi specifici ai quali la riflessione criminologica può fornire un contributo, segnatamente nella prospettiva della prevenzione primaria e secondaria.
Terradas' Vindicatory Justice: An Attempt at Formalization
Authors: Mazzola Riccardo
Published: June 2021

This article takes on Ignasi Terradas' latest book La justicia más antigua (2019) in the attempt to conceptualize "vindicatory justice" through a formalization - inspired by Theodor Geiger's Vorstudien zu einer Soziologie des Rechts - of its fundamental notions and principles. This study identifies (I) three key concepts constituting an essential lexicon of vindicatory justice: (I.i) offense, (I.ii) defenselessness (I.iii) composition; and (II) three basic principles underlying vindicatory justice: (II.i) principle of universal answerability (PUA) (II.ii) principle of reconciliation (PR) (II.iii) principle of ancillary vengeance (PAV).
Understanding Residential Relocation Choices in Coastal Cities in the Face of Climate Change
Authors: Wang Haiyun , Searle Glen , Wang Siqin , Liu Yan
Published: June 2021

Climate change poses risks of inundation to low-lying coastal cities and may cause residential relocation and change in housing demand. Taking the City of Gold Coast in Queensland, Australia as a case study, this paper reports on a survey that investigates the potential responses of residents living in the coastal city to flood risks and how the responses may relate to their socio-economic status. Through a combined online and mail-based survey, our data show that people’s perceptions of flooding have an important impact on their relocation choices. Their perceptions and relocation choices are associated with their socio-economic background. Furthermore, residents’ preferences of dwelling types appear to be affected by the level of flood risks we hypothesise in the survey. The findings from this study provide empirical evidence for future residential zoning and urban development.
Impacto del capital social e innovación en la competitividad de productores de amaranto en México
Authors: Juárez Díaz Dolores , Coria Páez Ana Lilia , Tejeida Padilla Ricardo
Published: June 2021

Esta investigación se realizó con productores de amaranto del pueblo de Santiago Tulyehualco en la Ciudad de México y tiene como objetivo medir la relación entre el capital social, la innovación y la competitividad, el enfoque de investigación utilizado fue el mixto y se utilizó el método econométrico. El trabajo se llevó a cabo en dos etapas; en la fase cualitativa se realizaron entrevistas a los productores y con esa información se elaboró el cuestionario aplicado en la parte cuantitativa. Con los datos obtenidos se llevó a cabo el análisis de regresión, los resultados muestran que el impacto del capital social en la competitividad de las Mipymes productoras de amaranto, no es significativo; a diferencia de la innovación, cuyo impacto si es significativo en la competitividad de este tipo de empresas.
Los indicadores de gestión
Authors: Gaytán Cortés Juan
Published: June 2021

El éxito de la organización, en gran medida se puede garantizar al contar con un adecuado sistema de indicadores de gestión que ordene y estructure los aspectos clave del negocio con el fin de trazar el camino que debe seguir una organización y así, asegurarnos que no se sale de él, en el corto y en el largo plazo.
Carta del editor
Authors: González Alvarado Tania Elena
Published: June 2021

Estamos muy contentos de presentar este número de Mercados y Negocios, que fue trabajado en su mayor parte durante el periodo de aislamiento. Sabemos que el compromiso con la ciencia y el conocimiento no da tregua, aún en tiempos de pandemia. Estamos conscientes de que la mejor forma de responder ante la nueva realidad es con el trabajo. El trabajo de investigación cercano a la realidad imperante facilita la obtención de conclusiones acertadas, decisiones bien tomadas y resultados favorables ante los problemas que la sociedad enfrenta.
Angle Trisection, Bhaskara’s Proof, and Pythagorean Theorem
Authors:   Cebu Technological University, Cebu City, Philippines, De Catalina Emiliano
Published: June 2021

This paper deals with 1) angle trisection, 2) Bhaskara’s first proof, and 3) Pythagorean theorem. The purpose of this paper is threefold. First, to show a new, direct method of trisecting the 900 angle using unmarked straight edge and compass; secondly, to show Bhaskara’s first proof of the Pythagorean theorem (c2 = a2 + b2) as embedded in this new, direct trisection of the 900 angle; lastly, to show the derivation of the Pythagorean theorem from this trisection of the 900 angle. This paper employs the direct dissection method. It concludes by presenting four points: a) the concept of trisectability as distinct from concept of constructability; b) the trisection of the 900 angle as really a new, different method; c) Bhaskara’s first proof of the Pythagorean theorem as truly embedded in this trisection of the 900 angle and; d) another way of deriving Pythagorean theorem from this trisection of the 900 angle.
A Sound-based Machine Learning to Predict Traffic Vehicle Density
Authors:   University of San Jose-Recoletos, Cebu City, Philippines, Flores Geoferleen , Piedad Eduardo Jr. ,   University of San Jose-Recoletos, Cebu City, Philippines, Figueroa Anzeneth ,   University of San Jose-Recoletos, Cebu City, Philippines, Tumamak Romari ,   University of San Jose-Recoletos, Cebu City, Philippines, Berdon Nesrah Jane Marie ,   University of San Jose-Recoletos, Cebu City, Philippines
Published: June 2021

Traffic flow mismanagement is a significant challenge in all countries especially in crowded cities. An alternative solution is to utilize smart technologies to predict traffic flow. In this study, frequency spectrum describing traffic sound characteristics is used as an indicator to predict the next five-minute vehicle density. Sound frequency and vehicle intensity are collected during a thirteen-hour data gathering. The collected sound intensity and frequency are then used to learn three machine-learning models - support vector machine, artificial neural network, and random forest and to predict vehicle intensity. It was found out that the performances of the three models based on root-mean-square-error values are 12.97, 16.01, and 10.67, respectively. These initial and satisfactory results pave a new way to predict traffic flow based on traffic sound characteristics which may serve as a better alternative to conventional features.
The Market Distortion Effect of Government Intervention in Higher Education
Authors:   Cebu Normal University, Cebu City, Philippines, Cutamora Jezyl
Published: June 2021

In the Philippines, a mixture of public and private higher education institutions (HEIs) exists. Because of the government subsidy among the public HEIs, the major concern of the private sector is the “uneven playing field”. This study hopes to eliminate this unhealthy competition and market distortion in the educational landscape. This study utilizes the quantitative non-experimental retrospective explanatory design. Results show that regardless of the extent of state intervention, the market can be distorted. Hence, assigning specific programs to be offered based on the type of HEI is a good alternative. The programs to be fully subsidized and offered by the government are agriculture, sciences, engineering, manufacturing and construction, and humanities and arts (HA) while services, health and welfare, education and social sciences, business and law programs will be for private sector service providers. This stimulates healthy competition among the HEIs leading to a better quality of education.
A importância do planejamento tributário para as micros e pequenas empresas
Authors: Shan Yang Wu Wesley , Rabelo Henrique Marcelo , Saporito Antonio , Braz Silva Sandro
Published: June 2021

O objetivo deste artigo foi demonstrar a importância do planejamento tributário para as micros e pequenas empresas. Foram utilizados os métodos descritivo, qualitativo e documental. Uma empresa de pequeno porte tributada pelo Simples Nacional foi selecionada e de suas demonstrações contábeis do ano de 2019 foram extraídos dados que permitiram comparar a tributação relacionada ao imposto de renda e contribuição tributária pelos vários regimes possíveis. Os resultados apontaram para os seguintes valores: no regime pelo Lucro Presumido de R$ 126.831,47, no Regime do lucro Real de R$ 136.891,33, e no Simples Nacional de R$ 55.130,00. Portanto, torna-se evidente que a empresa deve manter o regime de tributação Simples Nacional, pois ele lhe proporciona uma despesa tributária menor.
IMPLEMENTASI PROGRAM ECOPRENEURSHIP PADA SISWA ATTENTION DEFICIT HYPER ACTIVITY DISORDER (ADHD) DI SEKOLAH DASAR INKLUSIF
Authors: Aryanto Sani , Junaidi Febi , Hartati Tatat , Rahman Rahman
Published: June 2021

This research was conducted to describe the implementation of the ecopreneurship program in ADHD students including the characteristics, approach/method, parties involved, the impact, and the obstacles of implementation of ecopreneurship program in ADHD students in Inclusive Elementary School. This research uses a qualitative approach with a case study method conducted at SDN Cibabat Mandiri 2 Kota Cimahi. The subject of this study was ADHD students as the primary informant supported by secondary data from orthopedagog, classroom teachers, and extracurricular teachers. Based on the results of the research that has been done, it can be known that ADHD students have very active characteristics and tend to be impulsive when participating in ecopreneur ship programs, but the assisted learning approach through scaffolding method is the key to the teacher's success in directing ADHD students to stay focused on the ecopreneurship program. The implementation of ecopreneurship's program has 3 main impacts on the development of ADHD students, including (1) Internalization of ecopreneurship values; (2) improvement of life skills; and (3) the creation of social interactions as an effort to improve the competence of ADHD students. The results of this study are new findings and can be used as a reference for Inclusive Elementary School in providing an overview of the internalization of ecopreneurship values in ADHD students as a reference for teachers or orthopedagog in developing innovative environmentally based learning patterns in ADHD students in Inclusive Elementary School.
SOCIAL EMOTIONAL LEARNING PROGRAM FOR BUILD RESPONSIBLE CHARACTER OF STUDENTS IN ELEMENTARY SCHOOL
Authors: Farah Adiba Lu’lu’a Farah Adiba , Latip Asep Ediana
Published: June 2021

The aim of this research was describe Social Emotional Learning (SEL) Program for build responsible character of students in elementary school. The approach for this study was qualitative. The main method of this study was library research that supported with filed research. Library research that referred in this study was an activity to collected data, read, took notes, and processed the data that related with Social Emotional Program in Schools. It was obtained from books, journals, and articles. There are 5 main journals supported by 10 other. The researcher was collected the data from documents, research notes, and interviews. The interviewees are people who have direct contact with Social Emotional Program such as Head of Social Emotional Program Department, teachers, students and parents of Kharisma Bangsa Elementary School. This study used purposive sampling technique. The instruments of this research were document check list, notes, and interview guidelines. Data analysis was achieved through a content analysis technique. The result showed that Social Emotional Learning Program can build responsible character of students in elementary school. It can be obtained by growing social awareness, self-management, self-awareness, responsible decision making, and relationship skills after implementing Social Emotional Learning Program. The Social Emotional Learning Program was effective to build the responsibility by using some approaches there were Explicit SEL Instruction, Teacher Instructional, and Integrated with curriculum areas that supported by several strategies between PATH, RC, 4R’s, and RULER.
La salud emocional y los resultados académicos
Authors: Zavala Taylor Gaspar Manuel
Published: June 2021

En la educación de un ser humano existen factores que determinan este proceso. Desde la niñez, los primeros responsables –los padres de familia– son quienes inician dando las bases fundamentales, como los hábitos y el afecto; en una segunda etapa –educación formal–, los niños y jóvenes reciben la formación en conocimientos que los llevará a ir desarrollando sus competencias y habilidades, pues será muy importante que todos los que intervienen en la educación –papás y docentes– sepan estar atentos al desarrollo emocional de los alumnos, al haber una estrecha relación entre el manejo de las emociones y la adquisición del conocimiento.
Estructura analógica: soporte de creatividad lingüística en greguerías para aprender verbos
Authors: Alvarez de la Cruz Lucila
Published: June 2021

Una de las competencias más importantes en bachillerato es el desarrollo de las habilidades de escritura; por eso, es indispensable promover estrategias de aprendizaje gramatical de forma situada que doten a los estudiantes de conocimientos explícitos sobre la lengua para comunicar sus ideas eficazmente. Para ello, el texto literario es un recurso valioso que fortalece la competencia lingüística a través de la creación poética. Aquí se ofrece una propuesta didáctica, cuyo soporte es la estructura analógica; en ella se combinan las funciones poética y metalingüística de la lengua, por medio de la producción de greguerías, para analizar cuál es la función del verbo. De esta manera, al reconocer el tipo de sintagma verbal escrito, se confirma si la intención comunicativa ha sido expresada correctamente.
Rutas formativas desde la práctica reflexiva
Authors: López Peniche Ma. Ofelia Béjar
Published: June 2021

Las rutas formativas desde la práctica reflexiva son una propuesta de formación y autoformación docente originada en la Universidad Iberoamericana, en respuesta al reto en esta línea que enfrentan los profesores de pregrado. Se orienta al profesor hacia el autorreflexión y la reflexión en conjunto con otros profesores, para obtener mayor certidumbre y confianza al implementar innovaciones pertinentes para su enseñanza. La propuesta se fundamenta en la metodología del aprendizaje experiencial, y en la propuesta del profesional reflexivo de Donald Schön.
Creativity and attitudes in English language learning
Authors: Ruiz Ortega Rosario de los Milagros
Published: June 2021

Una de las competencias más importantes en bachillerato es el desarrollo de las habilidades de escritura; por eso, es indispensable promover estrategias de aprendizaje gramatical de forma situada que doten a los estudiantes de conocimientos explícitos sobre la lengua para comunicar sus ideas eficazmente. Para ello, el texto literario es un recurso valioso que fortalece la competencia lingüística a través de la creación poética. Aquí se ofrece una propuesta didáctica, cuyo soporte es la estructura analógica; en ella se combinan las funciones poética y metalingüística de la lengua, por medio de la producción de greguerías, para analizar cuál es la función del verbo. De esta manera, al reconocer el tipo de sintagma verbal escrito, se confirma si la intención comunicativa ha sido expresada correctamente.

Abstract

This in an exploratory research about students’ attitudes towards English language learning and teaching creativity at the Universidad Autónoma del Estado de Hidalgo (UAEH). The participants were learners in the first and last English course, which is the sixth semester. The purpose was to find out what kind of tendencies the results exhibit as students advance in studies, and to what extent teachers’ creativity might have influenced the outcome. Data was collected from 297 students currently enrolled in the Instituto de Ciencias Sociales y Humanidades (ICSHU), using a questionnaire and focus group interviews. Results showed that attitudes to English language learning are extremely positive among basic level students, but negative feelings increase in the last course. Regarding creativity, it was found that teachers are too enclosed by the school policies that they do not perform at their fullest potential creativity.
La Monografía en el Bachillerato Internacional.
Authors: Díaz Dena Diana Cecilia
Published: June 2021

En el marco del nuevo Modelo Educativo para la Educación Obligatoria (MEPEO), el aprendizaje situado constituye el perfeccionamiento de la práctica docente para alcanzar el desarrollo de las competencias para el siglo XXI. Por su parte, la investigación individual propuesta como la asignatura Monografía por el Programa del Diploma de Bachillerato Internacional (IB, por sus siglas en inglés), del Centro de Educación Media de la Universidad Autónoma de Aguascalientes, perfila la generación de estas competencias a través de una técnica de aprendizaje situado, basada en una metodología de aprendizaje de resolución de problemas auténticos, lo cual se enmarca, a su vez, en la creación de habilidades de pensamiento superior. En este proceso heurístico, es importante repensar la investigación como un acercamiento a eclipsar estos conceptos, vehículo de movilización de saberes, medio de producción de aprendizaje situado, y puente de la vida académica media hacia la profesionalización.
Indicadores de aprendizaje en educación media superior para la formación en desarrollo sostenible a través de entornos virtuales
Authors: Acosta Collazo Francisco Javier
Published: June 2021

Como parte del análisis de la experiencia de aprendizaje en el contexto del curso de “Ecología y desarrollo sustentable” en el nivel medio superior de la Universidad Autónoma de Aguascalientes (UAA), se presentan los resultados de seguimiento a las evidencias de aprendizaje generadas en los entornos virtuales mediante la aplicación de indicadores de aprendizaje adaptados al curso de enero-junio 2020. La primera parte del artículo reafirma la importancia de la educación para el desarrollo sostenible en la actualidad, seguido de la trascendencia de los indicadores en el enfoque por competencias en el nivel educativo, así como la aplicación de estrategias educativas relacionadas con la enseñanza del desarrollo sostenible. La variada cantidad de información generada en los entornos virtuales permite el diseño y análisis de indicadores de aprendizaje que pueden proporcionar información clave para la planificación, seguimiento y evaluación en los cursos impartidos en la educación superior y media superior.
IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load
Authors: Hussmann Dianna , Starnawska Anna , Kristensen Louise , Daugaard Iben , Thomsen Astrid , Kjeldsen Tina E. , Hansen Christine Søholm , Bybjerg-Grauholm Jonas , Johansen Karina Dalsgaard , Ludvigsen Maja , Kristensen Thomas , Larsen Thomas Stauffer , Møller Michael Boe , Nyvold Charlotte Guldborg , Hansen Lise Lotte , Wojdacz Tomasz K.
Published: June 2021

Currently, no molecular biomarker indices are used in standard care to make treatment decisions at diagnosis of chronic lymphocytic leukemia (CLL). We used Infinium MethylationEPIC array data from diagnostic blood samples of 114 CLL patients and developed a procedure to stratify patients based on methylation signatures associated with mutation load of the IGHV gene. This procedure allowed us to predict the time to treatment with a hazard ratio (HR) of 8.34 (95% confidence interval [CI]: 4.54-15.30), as opposed to a HR of 4.35 (95% CI: 2.60-7.28) using IGHV mutation status. Detailed evaluation of 17 cases for which the two classification procedures gave discrepant results showed that these cases were incorrectly classified using IGHV status. Moreover, methylation-based classification stratified patients with different overall survival (HR=1.82; 95% CI: 1.07-3.09), which was not possible using IGHV status. Furthermore, we assessed the performance of the developed classification procedure using published HumanMethylation450 array data for 159 patients for whom information on time to treatment, overall survival and relapse was available. Despite 450K array methylation data not containing all the biomarkers used in our classification procedure, methylation signatures again stratified patients with significantly better accuracy than did IGHV mutation load regarding all available clinical outcomes. Thus, stratification using IGHV-associated methylation signatures may provide better prognostic power than IGHV mutation status.
Arqueología de Tacna
Authors:   Universidad Nacional Jorge Basadre Grohmann, Vela-Velarde Carlos
Published: June 2021

El presente libro, por la naturaleza del problema, debe ser ubicado en el campo de las ciencias sociales, especíﬁcamente en la ciencia arqueológica; por su contenido, corresponde al estudio de las sociedades de la prehistoria que ocuparon el departamento de Tacna. Si bien es cierto este libro recoge información desarrollada por investigadores especializados en la arqueología de Tacna, además de los míos propios, es producto también de muchas conversaciones, mucha lectura, participación en eventos o excavaciones, salidas al campo, y de mucho tiempo para concebirlo.
Fertilidade do solo em pastagens no município de Vitória do Xingu, Pará, Brasil
Authors: Correia Karoline Amaral , Silva Sandra Andréa Santos da , Silva Rainério Meireles da , Hamid Sheryle Santos , Farias Vivian Dielly da Silva , Costa José Farias , Santos Marcos Antônio Souza dos
Published: June 2021

O município de Vitória do Xingu, no estado do Pará, apresentou rebanho bovino de cerca de 150 mil cabeças em 2019, evidenciando o potencial produtivo da região. Como subsídio para a expansão da atividade pecuária é necessário o desenvolvimento de estudos que visem à manutenção da qualidade do solo nos sistemas de produção, subsidiando alternativas de manejo. O objetivo do trabalho foi analisar os parâmetros físico-químicos do solo, considerando o período climático (chuvoso e seco) e a profundidade (0-20 e 20-40 cm), em uma propriedade particular, localizada no município de Vitória do Xingu, estado do Pará. Foram adotados três tratamentos, sendo T1 (vegetação secundária), T2 (pastagens de 10 anos) e T3 (pastagem de 30 anos). Para a análise estatística dos atributos foi utilizado o teste não-paramétrico de Wilcoxon (P<0,05). Todos os solos foram classificados com textura média. A densidade do solo foi maior em T3 e T2. A densidade de partículas foi maior em T1, seguido por T2 e T3. As áreas de pastagem apresentaram melhores condições de fertilidade que T1. O resultado do teste de Wilcoxon demonstrou que na camada superficial (0-20 cm), houve diferenças significativas entre os atributos analisados, sendo tais diferenças mais evidentes no período chuvoso. Os atributos diferiram na camada superficial de T1 em razão do período climático. O mesmo ocorreu com a camada subsuperficial de T3. A pastagem com 30 anos mostrou-se em maior estádio de degradação que as demais, sendo necessária a intervenção voltada para melhoria dos pastos, de modo a contribuir no potencial produtivo e de recuperação de pastagens na propriedade rural.
Os significados atribuídos pela mulher à cicatriz consequente à cirurgia cardíaca de peito aberto: Um olhar terapêutico ocupacional
Authors: Marques Jéssica Raquel de Souza , Albuquerque Valéria Barroso de , Lima Francisca Helena Gadelha de , Munguba Marilene Calderaro da Silva
Published: June 2021

Introdução: As cirurgias cardíacas são terapêuticas complexas que envolvem transformações na vida do sujeito. Essas mudanças implicam em alteração na rotina, na autoestima e na autoimagem principalmente nas mulheres. A Terapia Ocupacinal possuindo habilidade para avaliar e compreender o sujeito em todos os contextos em que está inserido, auxilia a mulher no pós cirúrgico cardíaco. Objetivo: Compreender os significados atribuídos pela mulher à cicatriz consequente à cirurgia cardíaca de peito aberto, sob um olhar terapêutico ocupacional. Metodologia: Trata-se de uma pesquisa descritiva e exploratória, com abordagem qualitativa. Foi realizado no hospital Dr. Carlos Alberto Studart Gomes – Hospital do Coração de Messejana, em Fortaleza, Ceará, Brasil, no período de outubro de 2020 a janeiro de 2021. Participaram do estudo cinco mulheres que realizaram cirurgia cardíaca de peito aberto, com idade entre 23 e 50 anos. O estudo em tela teve como técnica de coleta de informações a entrevista individual e estruturada e como método de análise a de conteúdo, na modalidade análise temática. Resultados: A pesquisa gerou quatro núcleos de sentido para uma discussão mais ampla, sendo eles: O estigma da cardiopatia; Suporte espiritual; O medo da dependência nas AVD; A ressignificação da cicatriz. Conclusão: As mulheres participantes da pesquisa mostraram uma resiliência de suma importância, onde compreenderam que o corpo é um templo delas, que precisa ser reconhecido e cuidado.
Avaliação da oferta e da produção das especialidades odontológicas em serviços públicos de atenção secundária em um estado do nordeste brasileiro
Authors: Lima Eduardo Brito de , Melo Radamés Bezerra , Sá Carlos Diego Lopes , Cruz Kamila Rocha Silva da , Moraes Raissa Pinheiro , Bernardino Ranelle de Souza
Published: June 2021

No Ceará a expansão da oferta dos Centros de especialidades odontológicas (CEO) é recente. Deste modo, o presente estudo teve como objetivo avaliar a oferta e a produção dos CEO do Ceará no período de 2008 a 2014 a partir de dados secundários registrados no Sistema de Informação do Sistema Único de Saúde. Os dados foram expressos em forma absoluta e percentual e utilizaram-se os testes do qui-quadrado e a correlação de Spearman. Os resultados mostraram que o número de procedimentos no ano de 2008 foi de 280222 (9.2%), havendo uma leve redução para 253370 (8.3%) em 2009, um aumento para 677664 (22.3%) em 2010, com quedas subsequentes em 2011 (n=525259, 17.3%), 2012 (n=430991, n=14.2%) e 2013 (n=291666, 9.6%) reassumindo crescimento em 2014 (n=457192, 15.1%), totalizando 3035626 procedimentos no período de 2008-2014. Não houve correlação estatisticamente significante do número de procedimentos com o tempo do período avaliado (p=0.444). Em relação ao tipo de gestão os CEO municipais, p=0.003, r=0.964 e os CEO estaduais, p=0.048, r=0.775) apresentaram crescimento significante no período avaliado. Apesar da expansão dos serviços de saúde bucal secundária no Ceará e do crescente número de procedimentos especializados registrados, a capacidade para resolver os problemas destes serviços ainda é considerada um desafio para os gestores e profissionais da saúde bucal.
Determination of the application of contradictoire delimitatie principles in collecting physical data in the magetan national land agency office (study in magetan district)
Authors: Puriani Wahyu Dwi , Handayani I Gusti Ayu Ketut Rachmi , Karjoko Lego
Published: June 2021

The determination and stipulation of appropriate limits with the principle of Contradictoire Delimitatie becomes the main keys before implementing the land measurement. Lawsuit could arise which results in re-measurement and even the cancellation of the certificate. This research is normative research type (doctrinal research), statute approach and conceptual approach and focuses to the literature study; the research source data is secondary data. The mechanism for determining and stipulation boundaries in land registration has applied the principle of safety. The law consequence if the determination and stipulation boundaries in land are not accordance with the fact in the field resulting in the absence of legal certainty for the certificate of land rights. Conclusion and suggestion in this research is in determination and determination of land plot boundaries in order to achieve legal certainty must in accordance with PP No. 24 of 1997 and PMNA/KaBPN No.3 (Regulation of the Minister of Agrarian and Spatial Planning/Head of BPN) of 1997. Magetan Regency National Land Agency Office before implementing the measurement activities must be thoroughly in the process of determination of land plot boundary in order to reaches the law certainty, it can be accounted for.
Effects of environmental factors on reef fish assemblage structure in the southeastern US Atlantic
Authors: Glasgow DM , Reichert MJM , Quattro J
Published: June 2021

Environmental variation influences fish assemblage structure; however, fish assemblage composition shifts due to natural or anthropogenic stressors have been observed in marine ecosystems worldwide, altering ecosystem structure and function, and fisheries sustainability. Previous research in waters off North and South Carolina (USA) was limited in scope and repeatability or did not quantify fish assemblages at a scale suitable for monitoring composition shifts. Concurrent chevron traps, underwater video, and environmental data from an annual fishery-independent survey were used to characterize the environment and enumerate demersal reef fishes caught in the traps, and priority fish species observed in video in depths ~15-110 m. Multivariate analyses detected assemblage patterns and environmental influences. An 8-variable (distance to shelf edge, depth, consolidated substrate size, latitude, percent biotic cover, temperature, undercut height, biotic class) model predicted assemblages, while 4 variables explained the greatest variation (distance to shelf edge [19%], depth [15%], consolidated substrate vertical relief [4%], size [4%]). The largest number of discriminator species occurred in mid- to outer shelf areas with greater substrate complexity (i.e. increasing substrate size and relief). Assemblages dominated by Centropristis striata at depths (~15-40 m) with little substrate complexity transitioned towards assemblages dominated by Pagrus pagrus, higher prevalence of larger-bodied predators, and invasive Pterois spp. at depths (~40-110 m) with greater substrate complexity. Understanding baseline assemblage characteristics and natural drivers of variability in fish assemblage structure is vital to conservation and management efforts that monitor changes in population abundance, the presence/absence of key species, and stressor-induced modifications of local assemblages, which are all measures of ecological health that underpin comprehensive assessments and management.
Open classess to local communities: A reflection analysis of a school environmental project
Authors:   School Advisor for Secondary Science Teachers of West Crete, Regional Educational Directorates of Crete, Kalathaki Maria
Published: June 2021

School Projects of Environmental Education (SPEE) promote discovery learning, through teamwork, by involving local communities, scientists, organizations, authorities and bodies and are carried out largely online in virtual environments. This research aimed to identify and highlight those characteristics of local communities that can be exploited by opening them up to classes with activities that are matched in experiential and inquiry teaching and learning. Specifically, through the frame of Education for Sustainable Development. This research required the development of a tool for the reflection analysis of environmental open classes in local communities with the open classes' learning environments and those components of learning environments, which support the inquiry teaching and learning procedure in a School Environmental Project. Teachers supplied students with focused questions and urged them to try to find their own answers. More specifically, teachers facilitated students as co-researchers to choose their own issues, to set the queries and decide the best methods to conduct their inquiry. This research demonstrates how Open Classes in social learning environments, offered experiences to students and teachers bringing them face to face with questionnaires, evidence, historical knowledge, and real problems, which had been missing from their previous learning and teaching experiences.
Scientific Skills and Concept Learning by Rural Women for Personal and National Development
Authors:   DEPARTMENT OF SCIENCE AND TECHNOLOGY EDUCATION UNIVERSITY OF JOS, PLATEAU STATE NIGERIA, Agbo Felicia Onyemowo , Isa Muluku A. ,   COLLEGE OF EDUCATION, ZUBA, ABUJA FCT.
Published: June 2021

This paper examined scientific skills and concept learning by rural women for personal and national development. The research design employed was a quasi-experimental one-group pretest and posttest design. A non-formal science programme package to enhance and empower the rural women's knowledge and skills in their daily activities (nutrition, sanitation, health, agriculture, and water use) was designed and validated by three experts from the Science Education Department of a University. The reliability coefficient was 0.80 and the programme was taught for six weeks to the rural women in order to determine its effect on the rural women's skills and knowledge in the five variables considered. The results showed that there was appreciable improvement on their skills and knowledge in health, water use, nutrition, sanitation, and agriculture. This supports the study of Nnachi (2008) who was of the opinion that training and practice increased rural women's skills. Based on these findings the researchers recommended that rural women should be empowered by science education for maximum productivity, self and national development.
Effects of Chemical and Radiation Sterilisation on the Biological and Biomechanical Properties of Decellularised Porcine Peripheral Nerves
Authors: Holland James D. R. , Webster Georgina , Rooney Paul , Wilshaw Stacy-Paul , Jennings Louise M. , Berry Helen E.
Published: June 2021

There is a clinical need for novel graft materials for the repair of peripheral nerve defects. A decellularisation process has been developed for porcine peripheral nerves, yielding a material with potentially significant advantages over other devices currently being used clinically (such as autografts and nerve guidance conduits). Grafts derived from xenogeneic tissues should undergo sterilisation prior to clinical use. It has been reported that sterilisation methods may adversely affect the properties of decellularised tissues, and therefore potentially negatively impact on the ability to promote tissue regeneration. In this study, decellularised nerves were produced and sterilised by treatment with 0.1% (v/v) PAA, gamma radiation (25–28 kGy) or E Beam (33–37 kGy). The effect of sterilisation on the decellularised nerves was determined by cytotoxicity testing, histological staining, hydroxyproline assays, uniaxial tensile testing, antibody labelling for collagen type IV, laminin and fibronectin in the basal lamina, and differential scanning calorimetry. This study concluded that decellularised nerves retained biocompatibility following sterilisation. However, sterilisation affected the mechanical properties (PAA, gamma radiation), endoneurial structure and basement membrane composition (PAA) of decellularised nerves. No such alterations were observed following E Beam treatment, suggesting that this method may be preferable for the sterilisation of decellularised porcine peripheral nerves.
A Novel Rat Tail Needle Minimally Invasive Puncture Model Using Three-Dimensional Printing for Disk Degeneration and Progressive Osteogenesis Research
Authors: Xia Dongdong , Yan Meijun , Yin Xin , Hu Wenhao , Zhang Chi , Hu Baiwen , Ge Ting , Wu Xiaochuan , Xiao Jin , Gao Liang , Liu Junqi , Tan Jun
Published: June 2021

Many studies focused on the annulus fibrosus (AF) injury in rodent tail model for the intervertebral disk degeneration (IDD) research. However, previous studies caused tremendous injury of intervertebral disk (IVD) by penetrating whole disk. This study aimed to build a progressive IDD rodent tail model by a novel device for precise and minimally invasive puncture in AF. A precise puncture device was customized by 3D Printing Technique. 40 rodent tail IVDs were randomly grouped as follows: group A, non-puncture; group B, annulus needle puncture (ANP) for 4 week; group C, ANP for 8 week; and group D, ANP for 12 week. Pre- and post-puncture IVD height on radiographs and IVD signal intensity on T2 magnetic resonance imaging (MRI) were measured. Average bone density (ABD) on the end of coccygeal vertebrae between punctured disk was measured on the radiographs. Hematoxylin and eosin, TUNEL staining methods, immunofluorescence for cleaved-caspas3 and immunohistochemistry for aggrecan and collagen II were performed. Progressively and significantly increasing IVD height loss and degenerative grade were observed following the time points. The ABD was respectively, 81.20 ± 4.63 in group A, 83.93±3.18 in group B, 92.65 ± 4.32 in group C, 98.87 ± 6.69 in group D. In both group C and group D, there were significant differences with group A. In histology, increasing number of AF cells was noted in group B. In both group C and D, the fissures in AF were obviously observed, and a marked reduction of AF cells were also observed. In all ANP groups, there were significant decrease in number of NP cells, as well as aggrecan and collagen II contents. TUNEL assay showed cellular apoptosis were stimulated in all puncture group, especially in group D. A progressive IDD rat model could be standardly established by the micro-injury IVD puncture using a novel 3D printing device. This animal model provided a potential application for research of progressive hyperosteogeny following IDD development.