bluuebunny/crossref_metadata_2025 huggingface dataset:
KİŞİ ADLARI-SİYASAL EĞİLİM İLİŞKİSİ:MERSİN ÜNİVERSİTESİ ÖRNEĞİ
Authors: Altan Cemal
Published: April 2018

Ad verme bireyin tanınmasını, diğer bireylerden
ayırt edilmesini sağlayan bir belirleyici unsur olduğu gibi,  aynı zamanda ailelerin kültürlerinin sonraki
nesillere aktarılmasını sağlayan bir taşıyıcı aktördür. Ailelerin kültürü
dediğimiz de yine toplumun sahip olduğu değerler ve normlardır. Toplumlar sahip
oldukları kültürleri yaşatmak isterler. Yaşatmanın bir yolu da ad vermedir. Bu
yolla toplumlar, toplumsal dinsel ve tarihsel kültürleriyle birlikte siyasal
kültürlerini de ad verme yoluyla sonraki nesillere aktarmaya çalışırlar. Bu
nedenle de toplumların sahip olduğu değerler zamana ve mekana bağlı olarak
değiştiği için, kişi adları da zamana ve konjoktöre göre değişir. İçinde
bulunulan zaman dilimi ve sahip olunan kültürel değerler, adların verilmesinde önemli
rol oynar. Bir çok faktör gibi siyasal kültür de ad vermede etkili olmaktadır.
Aileler ve biraz daha geniş tutarsak toplumun sahip olduğu etkin ve baskın
siyasal değerler, ad vermede çok etkili olmaktadır. Örneğin, sevilen bir
siyasal kişiliğin adından etkilenilerek çocuklara ad verme, ya da bir partinin
değerlerini benimseyen bir ailenin o partinin önde gelen adlarını çocuklarında
yaşatmak istemesi çok karşılaşılan bir durumdur. Ayrıca partilerin savundukları
değerleri benimseyen aileler, çocuklarının da benzer kültürü devam ettirmesini
istedikleri için, o kültürde çokça kullanılan adları çocuklarına verme
eğilimindedirler.
MEASURING VALUE ALONG THE SUPPLY CHAIN: A STUDY ON WHITE GOODS SECTOR
Authors: Gençer Yasin Galip
Published: April 2018

Perval scale was constructed in the literature as a measure of consumers’ perceived value for the retail industry. The study aims to generate a scale for measuring the perceived value of white goods customers in Turkey over the Perval scale, which is studied for several sectors in the literature. To understand the customer preferences of durable-goods consumers, we use the Perval scale that is highly studied in the literature as a basis for many sectors except white goods. Another goal of this study is to generate a survey to measure the perceived value of white goods’ customers, eventually to be named as WhitePerval. The outline of this survey generation process begins with examining the literature of Perceived Value, Consumption Values and Perval scale and continues with the adoptation process of Perval over white goods customers. Qualitative research design is used to clarify our research construct. For that purpose, content analysis and a survey design on the construct, validity and reliability analysis are also studied for WhitePerval. The adopted WhitePerval scale can be extended to cover perceived value measurement for all types of home appliance products and may also be an input for other models in other countries.
SEMBOLLER VE SOSYAL FONKSİYONLAR IŞIĞINDA BİR ELEŞTİRİ DENEMESİ: KÖY DÜĞÜNÜ – PIETER BRUEG
Authors: Tuna Serdar
Published: April 2018

Sanat yapıtları, bireysel ifade aracı oldukları gibi,
aynı zamanda da toplumun özelliklerini yansıtan, o toplumun yarattığı büyük
kültür şemsiyesinin bir parçasıdırlar ve bu nedenle, toplumu yansıtan birer
ayna işlevi görürler. Sanatçılar toplumsal olayları kendi süzgeçlerinden
geçirerek aktarırlar ve bu eserler aynı zamanda da gelecek nesillere bir değer,
bir estetik nesne olarak kalırken, günümüzde pek çok araştırmacı için de dönem
özelliklerini tespit etmeye yarayan birer belge olarak da kullanılırlar. Şüphesiz
ki sanat yapıtları, her şeyin çoğu zaman açık seçik anlatıldığı, görünenin her
zaman göründüğü gibi olduğu salt belgeler değillerdir. Sanat yapıtlarının
varlık amacı da bu değildir. Maddenin düşünce ile birleşmesi olarak da
tanımlanan sanat yapıtları, genel tanımı ile estetik nesnelerdir. Bu
araştırmada, Pieter Bruegel’in Köy Düğünü isimli çalışması, sanat eleştirisinin
betimleme ve yorumlama aşamaları ile sınırlı tutularak ele alınmış ve yapıt
üzerindeki elemanlar ve sembollerden yararlanılarak, dönem yaşamı incelenmeye
çalışılmıştır. Araştırmada, resme konu olan günlük yaşam unsurları incelenmiş,
kıyafetler, oturma biçimi, kullanılan aksesuarlar gibi unsurlardan anlamlar
çıkartılmaya çalışılmıştır.
İLKOKULLARDA SERBEST ETKİNLİKLER UYGULAMALARI DERSİNİN DEĞERLENDİRİLMESİ
Authors: Cinoğlu Mustafa , Bağcı Erdem
Published: April 2018

Bu çalışmanın amacı ilkokullardaki Serbest Etkinlikler Uygulamaları Dersini
sınıf öğretmenlerinin görüşlerine göre değerlendirmektir. Nitel bir araştırma
olan bu çalışmada tanımlayıcı durum araştırması yöntemi kullanılmıştır. Veri
toplama aracı olarak doküman analizi, gözlem ve yarı yapılandırılmış görüşme tekniği
kullanılmıştır. Elde edilen veriler araştırma sorularına göre gruplandırılarak
tablolaştırılmıştır. Verilerin analizi sonucunda; öğretmenlerin ve idarecilerin
dersle ilgili kılavuz kitap ve materyallere ihtiyaç duyduğu, dersin öğrencilere
okulu daha çok sevdirme amacına ulaştığı, öğrencilerin ilgi ve yeteneklerini
etkinlikler yoluyla ortaya çıkarabilmek için branş öğretmenlerinin ve çeşitli alanlarda uzmanların derse katkıda
bulunmaları gerektiği saptanmıştır. Son olarak da araştırma sonucunda ortaya
çıkan bulgulara dayalı olarak öneriler geliştirilmiştir. Serbest etkinlikler
dersinin uygulanması ve planlaması aşamasında sınıf öğretmenleri ile beraber
diğer uzmanlardan da yararlanılması, programın öğrenci ihtiyaçlarına göre süreç
içerisinde yeniden düzenlenebilecek şekilde esnek olması, ders ile ilgili
kılavuz kitap hazırlanması, dersin öğretmenlerine ve okul yöneticilerine hizmet
içi eğitim sağlanması ve aynı ilgi yeteneklere sahip diğer sınıftaki
öğrencilerle ortak çalışmalar yapılabilmesi önerilmektedir.
VISUAL IDENTITY OF THE ART SCHOOLS IN LATVIA
Authors: Titova Aiva , Strode Aina
Published: April 2018

Today, each of the most influential and popular organizations has a successful visual identity. Successful visual or corporative identity reveals the company's value and business sector. Institutional managers need to streamline corporate processes, including design identity. The objective of this research is to find out the necessity of the corporate identity development for the Jānis Simsons Madonas art school by studying and analyzing the importance of branding in the area of art education and analyze examples of corporate identity among Latvian art schools. This art school is the first that kind of schools in Latvia. The methods of research: theoretical –investigation and analysis of relevant literature, internet sources and regulatory documents, case object study– randomly selected schools from all over Latvia.
BOOK COVER SURVEY DESIGN – BOOK SALE INSTRUMENT
Authors: Greize Laura , Apele Diana
Published: April 2018

Nowadays, successful books cover design play a major role in selling books, but increasingly, book publishers use stereotypes and artistic expressions that can change their buyers, for example, using outworn natural sights, celebrity photos, or simply embodying clustering clippings. It is important to make the book noticeable, make design to interest and to “talk” with the client, to create an association or interest about the book, and, in the end, to buy it. Very often the book cover design concept helps to realize this aspect, which is closely related to consumer associations.Aim of the article: To study and analyze the use of stereotypes and cliches in the book design of book covers.Research methods used: theoretical: research and analysis of literature related to the sector and Internet resources.
HERITAGE OF INDUSTRIAL ARCHITECTURE IN NOWADAYS' CULTURAL ENVIRONMENT
Authors: Brokāne Natālija , Strode Aina
Published: April 2018

The aim of the article is to study the concept of industrial heritage and its examples, trends in the usage of old factory buildings, to carry out theoretical analysis of industrial tourism, to evaluate the possibilities of industrial tourism in Latvia and Rezekne, by performing a survey of residents of the city.In the modern world a large number of factories and objects of industrial heritage cannot exist for their primary purpose anymore: they are demolished to clear the territory for new buildings, they are reconstructed, rebuilt, transforming the factories for various needs and purposes. Their applications nowadays are very diverse, ranging from art galleries to hotels and technical parks. This is a solution to many problems related to old factories and their territories. Transforming factory buildings and territories creates opportunities for industrial tourism, which in turn promotes regional development, provides new job opportunities in the city, and develops economy.
MUSEUM EDUCATION AND EDUCATIONAL TECHNOLOGY, PEDAGOGICAL MATERIAL IN THE FRAMEWORK OF THE EUROPEAN COMENIUS REGIO ARCA.DIA.LOGUE PROGRAM: THE CASE OF TÉRIADE’S “27 GREAT ARTISTS’ BOOKS”
Authors: Macri Dimitra , Makris Ioannis
Published: April 2018

The cultural heritage of a museum, regardless of that museum’s size, is unique and richly deserves to become known to the public in general and the student community in particular. The purpose of the present publication is to showcase “27 Great Artists’ Books,” which is but one of the many treasures of the Tériade Collection housed in the Stratis Eleftheriadis Museum–Library in Mytilini, the capital of the island of Lesvos, Greece. More specifically, it seeks to promote the art videos which were designed and created on that seminal segment of the Tériade Collection within the framework of the European Program Comenius Regio Partnership ARCA.DIA.logue (2013–15). What is more, those art videos constitute the foundation of the present proposal which discusses a didactic approach addressed to European Secondary Education students. That approach comprises three stages and is indicative only: teachers may give it the shape that best serves the needs of their classes under their tutelage.
BOLESŁAW BREZHGÓ AS HISTORIAN OF THE LATGALIAN PEASANTRY
Authors: Lisov Alexander
Published: April 2018

The article shows the evolution of changes in the assessment of the personality of the historian Bolesław Brezhgó. He retained the principled positions of an objective scientist throughout his biography, despite the change in political and ideological attitudes. His active scientific work took place in the conditions of changing political regimes and doctrines for about 40 years, first in Belarus, and then in Latvia. The position of the scientist can be presented apolitical, but he repeatedly tried to cooperate in the cultural and scientific programs of national organizations throughout this time.Brezhgó witnessed and participated in the complex process of the formation of the Latvian statehood and the Latgalian national movement. He did not refuse proposals to publish his works. His objectivity was based on the rejection of the way to use the results of his own research for conjunctural, political purposes. Bolesław Brezhgó proceeded from the idea that historical material should form problems. It is necessary to raise questions that follow from this material. He did not try to analyze the material for uncharacteristic problems.
THE EXPERIENCE OF DESIGNING CLOTHES TOGETHER WITH STUDENTS OF TECHNOLOGY DEPARTMENT
Authors: Pospelova Olga
Published: April 2018

Lately, questions of cooperation of educational and creative processes have been revitalized. To form future handicraft teacher's expertise in tailoring, it is necessary to develop not only students' technological skills, but also creativity. Creating a collection of clothes is the process aimed at completing these tasks in the form of a specific product. The article presents the Pskov State University students' experience in fashion collection designing cluding the steps of the statement of technological problem, searching for a creative idea and stages of its implementation from the sketch to a ready set.The aim of the article: to describe the experience of developing collections of clothes by students of Pskov State University on the example of the collection “Lazurite”.Research methodology: observation, comparison, analysis, description.
FORMATION OF CREATIVE ACTIVITY OF STUDENTS IN THE STUDY OF GRAPHIC EDITORS IN THE SEWING INDUSTRY
Authors: Grinev Dmitry , Eliseyeva Natalya , Ivanova Daria
Published: April 2018

The article presents the psychological, pedagogical and methodical aspects of the development of students' creative activity. Examples of creative assignments when studying graphic editors in the sewing industry are presented.
Antibodies to myelin basic protein as a diagnostic marker of primary open-angle glaucoma
Authors: Cherednichenko Nina L. , Karpov Sergey M. , Baturin Vladimir A. , Barbos Yuliana A.
Published: April 2018

Recently, many authors resort to immunomolecular diagnostics of glaucoma. We found conflicting information about the concentration of antibodies to the myelin basic protein (AB to MBP) in primary open-angle glaucoma in the literature.

Aim: to determine the concentration of antibodies to the myelin basic protein in the serum of patients with primary open-angle glaucoma to assess the diagnostic significance of the test.

Materials and methods. We included 48 people aged from 42 to 79 years: fourteen people had the diagnosis of the first stage of primary open-angle glaucoma (POAG), 10 people had the second (advanced) stage of POAG, 8 people had the III (far-gone) stage of POAG, and 16 subjects made the control group. Exclusion criteria: mature or almost mature cataract, age-related macular degeneration, severe concomitant ophthalmologic, neurological pathology, oncological and autoimmune diseases, glucocorticoid or immunosuppressive therapy, exacerbation of any acute and subacute respiratory infection, chronic inflammatory processes and craniocerebral trauma. The serum level of AB to MBP was determined by enzyme immunoassay method (ELISA).

Results. The concentration of AB to MBP was significantly higher in patients with first and second stages of POAG (177.5 63.93 g/ml and 262.63 34.78 g/ml, respectively) than in the control group (38.69 11.77 micron/ml, p 0.05). To establish the diagnosis of POAG in at risk patients it is appropriate to use the level of IgG to MBP 60 g/ml; the sensitivity of the method is 78% and its specificity is 87%.
Influence of eye diseases on the mortality rate of the population
Authors: Zolotarev Andrey V. , Karlova Elena V. , Miroshnichenko Elena V.
Published: April 2018

Evaluating of the correlation between quality of life, life expectancy and mortality rate is an important problem of modern ophthalmology. Many researchers note that eye pathology, which leads to a visual acuity decrease and blindness, has a significant impact on the mortality rate of the population. This review of literature is dedicated to studies examining the impact of eye diseases on the mortality rate of the population.
The experience of the first Russian latanoprost 0.005% (Trilactan) use in the treatment of primary open-angle glaucoma
Authors: Tatarintseva Alla O.
Published: April 2018

Summary. The problem of the reproduced (generic) and original (branded) medications coexistence on the pharmaceutical market is very relevant for Russia. Numerous polls have shown that very few among patients and even doctors clearly understand the differences between original drugs and generics, nor they know how these drugs are produced, and what advantages and weaknesses they have.

Aim. This paper covers the study of Trilactan (0.005% latanoprost, Solopharm, Russia) use in patients with different stages of primary open-angle glaucoma, and includes the analysis of the hypotensive effect and adverse events rate.

Material and methods. The study included 47 patients divided into 3 groups. The first group included 17 treatment-nave patients (32 eyes). The second group included 14 patients (28 eyes) previously treated with latanoprost 0.005% once a day in the evening at least for a month. The third group consisted of 16 patients (32 eyes) treated with beta-blockers or carbonic anhydrase inhibitors, in whom the target level of intraocular pressure had not been reached. All patients received 1 drop of Trilactan every evening; the observation lasted for 3 months.

Conclusions. The treatment was well tolerated. The intraocular pressure decrease was observed in all cases (p 0.05). Local and systemic adverse events under Trilactan treatment did not differ from possible side effects typical to the drugs of this pharmacological group in terms of its type and rate.
Risk assessment methodology: implementation of duration gap in corporate portfolios in order to reduce the systemic risk
Authors: Manco López Oscar , Medina Hurtado Santiago , Botero Oscar , Legendre François
Published: April 2018

In this article we propose a new methodology for measuring companies with financial risk exposure, based on the concept of duration in assets and liabilities management that can be applied in corporate portfolios. Risk indicators in banks usually try to measure the dynamic of accounts in the income statement and capital levels. With this research, we demonstrate how the methodology can be applied from banks to any company or industry sector. Then, we compare the methods for managing accounts in financial institutions and also identifying their adaptability to any type of corporation. We also made a comparison between the management elements used in financial markets and organizations assets, verifying their adaptability level. Finally, we present a real case study.
Modelos para evaluar la sostenibilidad de las organizaciones
Authors: Plasencia Soler Juan Antonio , Marrero Delgado Fernando , Bajo Sanjuán Anna María , Nicado García Miriam
Published: April 2018

La naturaleza compleja de la sostenibilidad organizacional ha desafiado a los investigadores, académicos, organismos e instituciones internacionales en la búsqueda de un modelo, muestra de esto es la gran variedad de marcos de trabajo, metodologías y métodos existentes en la literatura actual. La presente investigación abarca el estudio de los modelos para evaluar la sostenibilidad empresarial enmarcados en principios de desarrollo sostenible y teorías éticas de la responsabilidad social en el nivel empresarial. Para lograr lo anterior son identificadas las principales características distintivas y modificaciones de cada modelo desde su surgimiento, lo que permite su clasificación en tres grupos, para luego identificar sus ventajas y desventajas.
Библиометрический анализ научных публикаций в области промышленной экологии на примере Google Scholar
Authors: Боргоякова Кристина Семёновна , Бычкова Елена Феликсовна
Published: April 2018

В статье на основе библиографической базы данных Google Scholar проводится библиометрическое исследование русскоязычного и англоязычного сегмента научных публикаций в области промышленной экологии с сопоставлением базы данных Scopus. Выявляется динамика публикационной активности за период с 2011 по 2016 год: выделяется тематика научных публикаций, в которых представлено наибольшее количество публикаций по ключевым словам: изменение климата, биоразнообразие, отходы, переработка и пестициды.
Prevalencia y caracterización de las disfunciones sexuales en mujeres, en 12 ciudades colombianas, 2009-2016
Authors: Espitia De La Hoz Franklin José
Published: April 2018

Objetivo: establecer la prevalencia y caracterización de las disfunciones sexuales en una población de mujeres sexualmente activas, con edades entre 18 y 72 años, en doce ciudades colombianas.Materiales y métodos: estudio de corte transversal descriptivo. Se incluyeron mujeres mayores de 18 años con actividad sexual en las últimas 6 semanas, y residentes en Colombia. Se excluyeron las mujeres analfabetas, embarazadas o en primeros 6 meses posparto, pacientes psiquiátricos, con déficit neurológico o historial de cáncer. El estudio se llevó a cabo en la consulta externa ginecológica de instituciones hospitalarias privadas en 12 ciudades del país (Bogotá, Medellín, Cali, Barranquilla, Cartagena, Cúcuta, Ibagué, Bucaramanga, Villavicencio, Pereira, Manizales y Armenia) entre junio de 2009 y diciembre de 2016. Se realizó muestreo consecutivo. Se aplicó el Índice de Función Sexual Femenina validado en español. Se midieron variables sociodemográficas, antecedentes de salud sexual y reproductiva, comportamiento sexual, frecuencia de disfunción sexual global y por tipo de disfunción evaluada. Se realizó un análisis descriptivo de la información utilizando medidas de frecuencia absoluta y relativa para los datos. Se hace descripción estratificada por edad (40 años o menos y mayor de 40 años).Resultados: de un total de 72.894 mujeres candidatas a ingresar se analizaron finalmente 50.991 (69,95 %). La edad promedio fue de 30,9 ± 10,8 años. La prevalencia de disfunción sexual en el grupo estudiado fue del 32,97 % (16.812 mujeres). La puntuación del Índice de Función Sexual Femenina (IFSF) en las mujeres afectadas fue de 24,07 ± 6,18 puntos. Se presentaron dificultades con el deseo (32,97 %), el orgasmo (21,93 %), la excitación (16,86 %), la lubricación (14,79 %) y dolor (7,56 %). La mediana de disfunciones sexuales por mujer fue de 2, que se hizo presente en el 64,16 %.Conclusión: en las mujeres colombianas existe una prevalencia de disfunciones sexuales cercana a la tercera parte de la población, caracterizadas principalmente por trastornos del deseo y del orgasmo. Se requieren intervenciones para establecer un plan diagnóstico y terapéutico inmediato.
Emotional and behavioral problems in infants and preschool children: prevalence and sociodemographic risk factors
Authors: Uğur Çağatay , Yürümez Esra , Yılmazer Yasemin
Published: April 2018

Objectives: To determine the prevalence of behavioral disorders and the relationship between sociodemographic, environmental and family factors among infants and preschool children applied to psychiatry clinic. Methods: The sample comprised 355 children between 20-59 months of age and showing normal developmental pattern. After psychiatric assessments, the patients were referred to the child development unit for developmental assessment, support and psychoeducation. Ankara Developmental Screening Inventory (ADSI) was applied to all participants. Results: The mean age was significantly higher among the children applied to the clinic due to limit setting problems (LSP) than that of the children applied due to the other problems. The children with speech delay were the group applied to the clinic at the earliest age. Speech delay rates were higher among boys compared with girls. Sibling jealousy was more common among girls than boys. In the group with LSP, fathers’ education levels were lower than that of the group without LSP. There was no difference between children in terms of the number of siblings, birth order and family size. Conclusion: The findings indicate that limit setting was by far the most common problem among children applied to our clinic. Consequently, the utility of results to raise intervention strategies within limit setting should be developed and intervened earlier.
Cerebral organoids: a promising model in cellular technologies
Authors: Shnaider T. A.
Published: April 2018

The development of the human brain is a complex multi-stage process including the formation of various types of neural cells and their interactions. Many fundamental mechanisms of neurogenesis have been established due to the studying of model animals. However, significant differences in the brain structure compared to other animals do not allow considering all aspects of the human brain formation, which could play the main role in the development of unique cognitive abilities for human. Four years ago, Lancaster’s group elaborated human pluripotent stem cell-derived three-dimensional cerebral organoid technology, which opened a unique opportunity for researchers to model early stages of human neurogenesis in vitro. Cerebral organoids closely remodel many endogenous brain regions with specific cell composition like ventricular zone with radial glia, choroid plexus, and cortical plate with upper and deeper-layer neurons. Moreover, human brain development includes interactions between different brain regions. Generation of hybrid three-dimensional cerebral organoids with different brain region identity allows remodeling some of them, including long-distance neuronal migration or formation of major axonal tracts. In this review, we consider the technology of obtaining human pluripotent stem cell-derived three-dimensional cerebral organoids with different modifications and with different brain region identity. In addition, we discuss successful implementation of this technology in fundamental and applied research like modeling of different neurodevelopmental disorders and drug screening. Finally, we regard existing problems and prospects for development of human pluripotent stem cell-derived threedimensional cerebral organoid technology.
The search for microRNAs potentially involved in the selfrenewal maintaining of laboratory rat pluripotent stem cells
Authors: Sherstyuk V. V. , Medvedev S. P. , Ri M. T. , Vyatkin Y. V. , Saik O. V. , Shtokalo D. N. , Zakian S. M.
Published: April 2018

Self-renewal of cultured pluripotent stem cells is a complex process, which includes multiple functional and regulatory levels. Transcription factors, their target genes, chromatin modifiers, signaling pathways, and regulatory noncoding RNAs are involved in the maintaining of self-renewal. Studies of molecular and genetic bases of maintaining self-renewal and pluripotency in cultured mammalian cells are important to understand processes in preimplantation embryogenesis and to develop efficient techniques to obtain pluripotent stem cell lines for experimental biology and medicine. MicroRNAs (miRNAs) play an important role in pluripotency maintaining and reprogramming. However, involvement of this class of noncoding RNAs and functions of individual molecules are poorly studied. The goal of this study was the search for the miRNAs potentially involved in the pluripotency maintaining and reprogramming of Rattus norvegicus cells. We analyzed the expression of miRNAs in rat embryonic stem cells, induced pluripotent stem cells and embryonic fibroblasts using bioinformatic methods and data obtained with next generation sequencing. The analysis of differential expression between groups of rat pluripotent cells and fibroblasts, and the analysis of experimentally confirmed target genes of differentially expressed known rat miRNAs revealed novel potential players of pluripotency maintaining and reprogramming processes. In addition, novel members of these processes were revealed among novel rat miRNAs. The use of bioinformatic and systems biology approaches is the first step, which is necessary for choosing candidates for the subsequent experimental studies. The results obtained substantially improve our understanding of the self-renewal regulation system of the laboratory rat, a popular biomedical object, and our knowledge about the system in mammals.
Polymorphism T3111C of the Clock gene in ethnic groups of women from Russia and Buryatia
Authors: Kaluzhnaya O. V. , Semenova N. V. , Bairova T. A. ,  Madaeva I. M. , Belyaeva E. V. , Kolesnikova L. I.
Published: April 2018

Biological rhythms of organisms depend on both changing conditions of the external environment and internal “biological clock”. Circadian rhythms are the response of the organism to the change of day and night. They are some of the most important biological rhythms of organisms. Circadian rhythms are regulated by the group of circadian genes. It is known that women suffer from sleep disorders more often than men. Up to 50 % of menopausal women complain of problems associated with sleeping. The study involved 403 menopausal women aged from 45 to 60 years: 214 Russians (the average age is 52.74±6.28 years) and 189 Buryats (the average age is 51.95±5.13 years) living in Eastern Siberia (Irkutsk region, Irkutsk and Republic of Buryatia, Ulan-Ude). The prevalence of genotypes and alleles of the polymorphism T3111C of the circadian rhythm gene Clock (rs1801260) was studied in these groups. To this end, we conducted genotyping of DNA samples by polymerase chain reaction. It was shown that the compared groups have statistically significant differences in genotypes frequency (р = 0.001). It was found that in the group of Russian women the frequency of the TC genotype (p = 0.004) was significantly higher and the frequency of the TT genotype (p = 0.0001) was significantly lower than those in the sample of women of Buryatia. It was shown that in the group of Russian women allele 3111C is found in 30.4 % of cases, which is statistically significantly more often than in the group of Buryat women, where the frequency of allele 3111C was 19.3 % (p = 0.014).
Hippocampal glucocorticoid receptor and microRNA gene expression and serum cortisol concentration in foxes selected for behavior toward humans
Authors: Ovchinnikov V. Yu. , Antonov E. V. , Vasilyev G. V. , Shihevich S. G. , Shepeleva D. V. , Herbeck Yu. E.
Published: April 2018

In many cases, stress reactivity is one of the important bases of aggressive behavior. It appears as if reduced stress reactivity underlies an abrupt decrease in aggression towards man in domesticated animals. However, the mechanisms of this reduction have yet to be resolved. In this work, we used an experimental domestication model, the silver fox selected for many years for the response to humans to study cortisol stress reactivity in tame and aggressive foxes in response to immobilization in human arms. Additionally, these behavioral fox groups were explored for one of the important mechanisms of glucocorticoid negative feedback, the expression of the glucocorticoid receptor gene (NR3C1) in a portion of the dorsal hippocampus. In recent years, attention has been paid to differences in miRNA expression patterns between animals with different behavior and stress reactivity, as well as to miRNA regulation under stress. The same applies to NR3C1 mRNA as well. That is why we performed a miRNA-seq analysis on a portion of the fox dorsal hippocampus. It has been demonstrated that immobilization in human arms leads to significantly higher stressinduced cortisol levels in aggressive than tame foxes. At the same time, no differences have been found between hippocampal NR3C1 gene expression and the pattern of miRNA expression. Thus, reduced stress reactivity in foxes during selection for the absence of aggressive responses and for the presence of emotionally positive responses to humans does not seem to be associated with important mechanisms of regulation such as alterations in hippocampal NR3C1 gene expression or microRNA-mediated silencing.
Impact of glycolysis inhibitor (2-DG) and oxidation and phosphorylation uncoupler (2,4-DNP) on brain metabolites
Authors: Shevelev O. B. , Moshkin M. P.
Published: April 2018

Deviations in brain metabolism are the result of longterm pathological processes, which finally are manifested as symptoms of Parkinson’s or Alzheimer’s diseases or multiple sclerosis and other neuropathologies, as for example diabetic neuropathy. A deficiency of available energy for brain cells under neurodegenerative diseases is either developed due to age-dependent underexpression of genes that encode glycolytic enzymes or induced due to the uncoupling of oxidation and phosphorylation that could be mediated by inflammatory cytokines. Since the activity of many enzymes is under the control of adenosine triphosphate (ATP) or cofactors, such as nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), energy deficiency can cause metabolic changes in brain tissue. Some clinical studies using proton nuclear magnetic resonance spectroscopy (1H NMR spectroscopy) revealed metabolic changes in brain tissue in patients with neurodegenerative diseases. However, data from different authors are quite contradictory, probably because of the complex genesis of metabolic disorders. In the present study, we tested the hypothesis of multidirectional changes in metabolism under the impact of the oxidation and phosphorylation uncoupler 2,4-dinitrophenol (2,4-DNP) and under the impact of 2-deoxy-Dglucose (2-DG), blocking the access of glucose to the brain cells. 1H NMR spectroscopy showed that 2-DG leads to the predominance of excitatory (glutamine + glutamate) neurotransmitters over inhibitory ones (gamma-aminobutyric acid), and 2,4 DNP causes opposite effects. The biochemical mechanisms of the observed changes require a special study, but it can be noted that the ATP deficiency caused by inhibition of glycolysis and the ATP deficiency caused by the uncouplers are accompanied by differently directed changes in the intensity of the tricarboxylic acid cycle. These changes in the intensity of the Krebs cycle are correlated with differently directed changes in the balance of the exciting and inhibitory neurotransmitters. The obtained results show that 1H NMR spectroscopy can be an effective method of differentiated lifetime assessment of the available energy deficit caused by a general suppression of energy exchange in nerve cells or oxidation and phosphorylation uncoupling.
Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy
Authors: Klimov L. O. , Seryapina A. A. , Zarytova V. F. , Levina A. S. , Markel A. L.
Published: April 2018

Arterial hypertension is one of the most common chronic diseases in adults all over the world. This pathology can not only reduce patients’ life quality, but can also be accompanied by a number of complications. Despite the fact that there is a large group of antihypertensive drugs on the market, mainly representing different combinations of inhibitors of the renin-angiotensin system, adrenoreceptor blockers in combination with diuretics, there is no generally accepted “gold standard” for drugs that would not have side effects. The review discusses the main aspects of antisense oligonucleotides use in the context of arterial hypertension. It is well known that the medical implementation of antisense oligonucleotides aims to block the expression of particular genes involved in the pathology development, and a key advantage of this technique is a high selectivity of the effect. However, with the undoubted advantages of the method, there are difficulties in its application, related both to the properties of the oligonucleotides themselves (insufficient stability and poor penetration into cells), and to the variety of mechanisms of the origin of a particular pathology, arterial hypertension, in our case. The review provides a brief description of the main molecular targets for antisense treatment of hypertensive disease. The newest targets for therapy with oligonucleotides – microRNAs – are discussed. The main modifications of antisense nucleotides, designed to increase the duration of their effects and simplify the delivery of this type of drugs to the targets are discussed, in particular, combining antisense oligonucleotides with adenovirus-based expression vectors. Particular attention is given to antisense oligonucleotides in the complex with nanoparticles. The review discusses the results of the use of titanium dioxide (TiO2) containing antisense nanocomposites for the angiotensin converting enzyme in rats with stress induced arterial hypertension (ISIAH). It was shown that the use of antisense oligonucleotides continues to be a promising technique for studying the mechanisms of various forms of hypertensive disease and has a high potential for therapeutic use.
Influence of the biologically active dietary supplement Floravit® on the skin and hair structure in sable (Martes zibellina)
Authors: Loenko N. N. , Chernova I. E. , Kunitsina T. S.
Published: April 2018

It is important to search for new highly effective multicomponent compounds that are able to influence several of animals’ homeostasis systems simultaneously to improve the physiological adaptation of fur animals to different conditions of nutrition. This is the function of the feed additive Floravit® – a natural bioregulator. The compound is a combination of biologically active ingredients produced by the mycelial fungus Fusarium sambucinum. Studied was the effect of Floravit® on the structure of the skin and hair in adult female sable (Martes zibellina). The scientific and economic experiment was conducted at the JSC “Plemzavod Pushkinskyi” in the Moscow Region during the period of winter fur formation in October-November. The study of the morphological structure of the hair and skin cover was carried out in the chine, side and rump topographical areas. The structure of the guard hairs in the main topographical areas was examined on a scanning electron microscope. The experiment showed that administration of Floravit® per os to adult female sable at a dose of 1.0 ml per head per day throughout the period of winter pelt formation in October-November has an influence on the morphological structure of all the categories of hair on all topographic pelt areas. Animals in the test group exposed to Floravit® exhibited an increase in guide hair length on the chine and side, when compared to controls, by 4.1 mm (p < 0.001) and by 2.8 mm (p < 0.01), respectively. The length of guard hair on the chine, side and rump increased by 8.1, 7.8 and 7.8 mm (p < 0.001), respectively. An increase in down hair length was recorded in all areas of the pelt, when compared to controls, by 13.0, 4.5 and 6.3 mm (p < 0.001). An increase in dermal thickness was recorded in the chine area by 0.7 mm (p < 0.001). The specified changed in the skin and hair structure in sable adult females after using Floravit® have shown a positive influence on the quality of hair cover. As a result, bioregulator Floravit® takes part in the adaptation process of the sable organism to external factors.
The Correlation of Occupational Stress With Subjective Fatigue Women Workers In Weaving Loom Unit PT. X
Authors: Andarini Yulia Dwi , Eka Prasetya Tofan Agung
Published: April 2018

Background : An occupation with a high risk of work fatigue is an occupation in textile industry. The involvement of women in the textile industry sector in Indonesia is dominant. Women labors who run work on domestic and public sector will be less inclined a work fatigue. Subjective fatigue is the problem faced by women workers at production division weaving loom unit of  PT. X. Purpose : This study aimed to determine occupational stress correlation with subjective fatigue in weaving loom unit PT. X. Methods : Type of this observational analytic study was using a cross sectional design. The number of research subject were 95 people. An occupational stress is independent variable. The dependent variable is a subjective fatigue. Occupational stress measurement was using job stress indicator questionnaire. Subjective fatigue measurement was using Subjective Self Rating Test questionnaires. Chi square test used as significance test. All test used 95% confidence interval and significance level of p=0,05. Result : Chi square test result showed that occupational stress has significant association with subjective fatigue. Conclusion : An occupational stress has a positive correlation with subjective fatigue women workers in weaving loom unit PT. X.
Lamellar Body Count With Cell Dyn Emerald And Cell Dyn Ruby Methods On Preterm Birth
Authors: Widyastuti Erlinda , Imandiri Ario
Published: April 2018

Background: Lamellar bodies are produced by pneumocyte type II cells in the lung alveoli. Lamellar bodies are present in amniotic fluid in increasing quantities as gestation advances, 1 – 5 µm in size, similar in size to small platelets and can be counted on most electronic cell counters in hematology analyzer. Lamellar body count is useful for prediction of fetal lung maturity and neonatal respiratory distress syndrome. The current gold standard for determination of fetal lung maturity is the evaluation of phospholipids in amniotic fluid samples by thin-layer chromatography, but it is time-consuming and not continuously available at most institutions. In this study we compare Cell Dyn Emerald and Cell Dyn Ruby method, which is expected to be a review for lamellar body count method. Purpose:  The aim of this study was to analyze lamellar body count with Cell Dyn Emerald and Cell Dyn Ruby method on preterm birth. Methods : This was a cross sectional study. Thirty three samples study were inpatient’s amniotic fluid with premature rupture of membranes in Obstetry and Gynecology ward emergency room Dr. Soetomo Hospital Surabaya. Lamellar body count was counted with Cell Dyn emerald and Cell Dyn Ruby method. The statistical differences were assessed using the ANOVA test . Results : The results showed significant differences (t=49,04), lamellar body count with Cell Dyn Ruby method was much lower than Cell  Dyn Emerald method. The lowest result with Cell Dyn Ruby method was 3.38 x 103/µL and 17 x 103/ µL with Cell Dyn Emerald method. The highest results with Cell Dyn Ruby method was 98,2 x 103/ µL and 221 x 103/ µL with Cell Dyn Emerald method. Conclusion : Lamellar body count with impedance method (Cell Dyn Emerald) is significantly higher than optic method (Cell Dyn Ruby).
Asia and Climate Change: How It Will Play Out From the Bosporus to Djakarta
Authors: Lane Jan-Erik
Published: April 2018

Now that the measure of CO2 emissions has broken through 410 on the standard Keeling curve (Earth CO2 website), one may start drawing a scenario for climate change repercussions, here for the Asian continent. It pollutes most of all continents in terms of both greenhouse gases and many other pollutants. The threats to mankind comes in the form of sea level rise, fresh water shortage, less of potable water, shrinking of lakes and rivers, deoxygenation of oceans, less fish food and agriculture produce, energy shortages, omnipresent air conditioning, urban smog, water and sea pollution due to sewage and failures with landfills. Asia, hosting more than half of mankind, will suffer massively from global warming with millions of ecological refugees. The UN’s program, the COP21 by the UNFCCC, cannot stop Asia from reaching Hawking irreversibility, because it entails too weak global governance that is cheatable. The promise of complete decarbonisation is an illusion.
PEMBERDAYAAN GURU-GURU SMA MELALUI PELATIHAN TEKNIK MENULIS ILMIAH POPULAR DI MATARAM, NUSA TENGGARA BARAT
Authors: Wibowo Agus , AS Karuniana Dianta , Kuncoro Haryo
Published: April 2018

ABSTRACT: Training activities in West Mataram City, West Nusa Tenggara, aimed at: (1) to provide understanding among the senior high school teachers in Mataram City west Nusa Tenggara related subjects popular scientific writing, and the publication in mass media; (2) to train the senior high school teachers in Mataram west Nusa Tenggara related writing variety of scientific popular, so that they have a skill in this field. Target by the people of this activity is the senior high school teachers in Mataram City, West Nusa Tenggara, as many as 20 people. The activity was done in two important matters that are strongly associated with the popular writing techniques, which is the characteristic of scientific writing popular and strategies pierce the mass media. These are the activities of 20 May 2017. Early sessions, participants related to the understanding of articles, articles and scientific articles are popular. Next session, teachers learned how to write the interesting and lure editor. Instructors peel completed how to make leads but also tempting editors to choose articles and puts it. Based on the results of the training, the scientific writing of the article a supporting an increase in professional competence.  

ABSTRAK: Kegiatan Pelatihan teknik menulis ilmiah populer bagi guru-guru SMA di Kota Mataram, Nusa Tenggara Barat, bertujuan: (1) untuk memberikan pemahaman kepada para guru SMA di Kota Mataram Nusa Tenggara Barat terkait aneka teknik menulis ilmiah populer, dan celah-celah publikasi di media massa; (2) untuk melatih para guru SMA di Kota Mataram Nusa Tenggara Barat terkait menulis ragam ilmiah populer, sehingga mereka memiliki keterampilan pada bidang tersebut. Khalayak sasaran dari kegiatan ini adalah para guru SMA di Kota Mataram, Nusa Tenggara Barat, sebanyak 20 orang. Kegiatan ini dilakukan dalam dua materi penting yang sangat terkait dengan teknik penulisan ilmiah populer, yaitu karakteristik tulisan ilmiah populer dan strategi menembus media massa. Kegiatan ini dilakukan selama satu hari, yaitu tanggal 20 Mei 2017. Pada sesi awal, peserta diberikan pemahaman terkait apa itu artikel, artikel ilmiah dan artikel ilmiah populer. Pada sesi selanjutnya, para guru diajari bagaimana mengemas tulisan menjadi menarik dan memikat redaktur. Instruktur mengupas tuntas bagaimana membuat lead yang tidak hanya menarik, tetapi juga menggoda redaktur untuk memilih artikel dan menerbitkannya. Berdasarkan hasil pelatihan yang sudah dilakukan didapat beberapa kesimpulan di antaranya para guru sudah memiliki pemahaman dan terampil menulis artikel ilmiah populer sebagai penunjang peningkatan kompetensi profesionalisme mereka.
PROGRAM PENINGKATAN KETERLIBATAN ORANGTUA MELALUI KEGIATAN SENI PADA ANAK USIA DINI
Authors: Akbar Zarina
Published: April 2018

ABSTRACT: This study aims to increase parental involvement through art programs in early childhood. Participants of this program are mothers of the child learner in Early Childhood Education in Tangerang - Indonesia. Art programs are series of activities in the field of art that will be conducted jointly between the child-parent and facilitated by the tutor in early childhood education. Researchers take measurements before the program (pre-test) and after the art program is given (post-test) by using a scale of parental involvement in & nbsp & nbsp children who have been developed from previous research. The results of the analysis found significant. It means that there are significant differences between parental involvement before and after art programs are given.

 

ABSTRAK: Program pengabdian masyarakat ini bertujuan untuk meningkatkan keterlibatan orangtua melalui kegiatan seni pada anak usia dini. Partisipan dalam program ini yaitu orangtua khususnya ibu dari anak yang menjadi peserta didik di salah satu Pendidikan Anak Usia Dini (PAUD) di daerah Tangerang – Indonesia. Kegiatan seni yang diberikan dalam program ini merupakan sekumpulan beberapa kegiatan yang dilakukan bersama-sama antara orangtua-anak yang akan difasilitasi oleh tutor di PAUD tersebut. Efektivitas dari program ini dilakukan melalui pengukuran sebelum-sesudah program kegiatan seni diberikan dengan menggunakan skala keterlibatan orangtua terhadap anak yang telah dikembangkan dari penelitan sebelumnya. Hasil dari pengukuran tersebut didapatkan adanya perbedaan yang signifikan antara sebelum dan sesudah diberikannya program seni terhadap keterlibatan orangtua dengan anak. Program seni dinilai efektif dapat meningkatkan keterlibatan orangtua pada anak usia dini.

Kata Kunci: Keterlibatan Orangtua, Program Kegiatan Seni, Anak Usia Dini