bluuebunny/crossref_metadata_2025 huggingface dataset:
SUPPLY CHAINS FOR VALORIZATION OF OLIVE GROVE RESIDUES AND OLIVE OIL INDUSTRY BY-PRODUCTS: A REVIEW ON RESEARCH AND LITERATURE ON OLIVE BASED BIOECONOMY
Authors: YAVUZ Tümay
Published: January 2023

The residual biomass produced in the olive sector is the result of the large quantity of olive groves and olive oil manufacturers that generate byproducts with a potentially high energy content. Until now, the disposal and management of pruning residues and olive oil by-products has generally represented disposal problems which lead to environmental problems rather than opportunities for additional revenue. In this context, this study aimed to define a roadmap for studies in Turkey to untap the potential of olive grove residues and olive oil industry by-products and residues, (i.e., olive tree prunings, olive leaves, olive pomace) that could be used to produce high-added value products in an integrated biorefinery or in a bioenergy power plant. This paper presents a review on recent research on the valorization of olive by-products in line with the circular economy principles and the bioeconomy strategy and presents the literature which applies to design and management of olive biomass supply chains. Main objective is to provide a conceptual framework for developing and deploying an effective bioeconomy utilizing olive prunings and olive oil industry byproducts conducting a preliminary review of the olive oil chain residues in Europe and Turkey comparatively, assessment of technical potentials, biomass supply costs and allocation of biomass collection sites and energy production facilities with different supply chain scenarios. Biomass resource assessment, biomass feedstock supply chain design and management, and logistics optimization require multidisciplinary and interdisciplinary approaches. They need to be carried out properly in order to execute efficient projects in energy generation from biomass and/or extracting bio-commodities in biorefineries. Turkish researchers have adequate research on valorization methods for olive based biomass resources, but their studies are limited on general biomass supply chain design and particularly no research has been conducted for olive biomass resources. Taking all the aforementioned into account, the author proposes to conduct further studies on a biomass energy project including design of a supply chain network for energy valorization of olive grove residues and olive oil industry by-products in line with the common practice and being inspired by the leading countries like Spain and Italy, which will both contribute to circular business concept development and renewable energy capacity increase.
POSSIBILITIES AND LIMITS OF DIGITALIZATION TO INCREASE SUPPLY CHAIN RESILIENCE
Authors: WEBER Marc-andré , FRANKE Peter D. , AUMUELLER Ulrike
Published: January 2023

In case any unexpected circumstances occur, a supply chain may be heavily influenced with a wide range of negative consequences such as inability to deliver or large delays in delivery. Therefore, it is important for every supply chain and the companies that are involved in them to reduce these negative outcomes. In this context, the term Supply Chain Resilience (SCR) stands for the level of adaptability of a supply chain to respond to and recover from disruptions. A high SCR is given if re-maintaining operational continuity is quickly possible. As an example of unexpected disruptions, the COVID19-crisis showed major impacts on the functionality of global supply chains. The upcoming technologies of industrial Digitalization, mainly known as Industry 4.0, provide opportunities to increase SCR. In this paper, first a brief overview of different surveys is given to show the COVID19-impact on global supply chains and therefore prove the need to generally increase SCR. Second, an insight of how especially Digitalization may help to increase SCR is provided. Especially improving the data base for all supply chain partners, faster and more precise decision-making processes, including the use of Artificial Intelligence, are described. Finally, positive chances and major challenges of using Digitalization to increase SCR are addressed.
PROSPECTS FOR INTERLINKING TRANSPORT, SPATIAL, AND DEVELOPMENT PLANNING AT THE REGIONAL LEVEL IN SLOVENIA
Authors: GULIČ Andrej
Published: January 2023

The prospects for aligning transport, spatial, and development planning at the regional level in Slovenia are presented in this article. We focus primarily on assessing the possibility of linking and interweaving the contents of documents provided for existing legislation, as well as legislation that is in the preparation phase. First, we present the general factors of differentiation and connection between the documents of the considered areas of planning. Then, we present the substantive factors of differentiation and the connection between the documents at the state level. In the next chapter, we present emerging technologies and transport services and their inclusion in spatial, development, and transport planning in national documents and regional development programs. In the last part of the article, we present the final findings and proposals for the substantive integration of the preparation of transport, spatial, and development planning documents at the regional level in Slovenia. The article was prepared in the framework of the CARE4CLIMATE project – boosting greenhouse gas emissions reduction by 2020 with a view to 2030 – promoting sustainable transport, energy efficiency, renewable energies, and sustainable, climate-protecting land use in the transition to a low-carbon society.
A Method for Designing Multi-Layer Sheet-Based Lightweight Funicular Structures
Authors: Lu Yao , Alsalem Thamer , Akbarzadeh Masoud
Published: January 2023

Multi-layer spatial structures usually take considerable external loads with a small material usage at all scales. Polyhedral graphic statics (PGS) provides a method to design multi-layer funicular polyhedral structures, and the structural forms are usually materialized as space frames.
Our previous research shows that the intrinsic planarity of the polyhedral geometries can be harnessed for efficient fabrication and construction processes using flat-sheet materials. Sheet-based structures are advantageous over conventional space frame systems because sheets can provide more
load paths and constrain the kinematic degrees of freedom of the nodes. Therefore, they are more capable of taking a wider variety of load cases compared to space frames. Moreover, sheet materials can be fabricated into complex shapes using CNC milling, laser cutting, water jet cutting, and
CNC bending techniques. However, not all sheets are necessary as long as the load paths are preserved and the system does not have kinematic degrees of freedom. To find an efficient set of faces that satisfies the requirements, this paper first incorporates and adapts the matrix analysis method
to calculate the kinematic degrees of freedom for sheet-based structures. Then, an iterative algorithm is devised to help find a reduced set of faces with zero kinematic degrees of freedom. To attest to the advantages of this method over bar-node construction, a comparative study is carried
out using finite element analysis. The results show that, with the same material usage, the sheet-based system has improved performance than the framework system under a range of loading scenarios.
Design for Manufacture and Assembly (DfMA) of Digital Fabrication (Dfab) and Additive Manufacturing (AM) in Construction: A Review
Authors: Tuvayanond Wiput , Prasittisopin Lapyote
Published: January 2023

Design for Manufacture and Assembly (DfMA) in architectural, engineering, and construction (AEC) industry is attracting the attention of designers, practitioners, and construction project stakeholders. Digital fabrication (Dfab) and design for additive manufacturing (DfAM) practices are found in current needs for further research and development. The DfMA's conceptual function is to maximize the process efficiency of Dfab and AM building projects. This work reviewed 171 relevant research articles over the past few decades. The concept of DfMA and the fundamentals of DfMA in building and construction were explored. In addition, DfMA procedures associated with Dfab and DfAM, as well as its AM assembly process, were discussed. Lastly, the current machine learning research on DfMA in construction was also highlighted. Large research gaps in the DfMA for Dfab and DfAM can be filled to increase operational efficiency and sustainable practices.
An Innovative UAV with VTOL Capabilities
Authors: Pugi Luca , Berzi Lorenzo , Favilli Samuele , Franchi Lorenzo , Mattei Giuseppe , Fiorenzani Roberto , Casazza Armando
Published: January 2023

Object of this work is the design and the simulation of a hybrid UAV with VTOL capabilities that has been designed for landing on naval moving platforms. The work is focused on the innovative propulsion layout adopted on the UAV. Authors discuss how adopted low level control strategies can exploit the innovative features of the proposed system assuring a good rejection of transversal wind disturbances. Particular attention is dedicated to low level modelling and control of the system emphasizing how choices regarding low level actuation and control should improve performances and robustness of the system.
Potential Genetic Biomarkers of Suicide Risk in the Mexican Population: A Systematic Literature Review
Authors: Garcia-Quiñones Juan Angel , Sanchez-Dominguez Celia Nohemi , Serna-Rodríguez María Fernanda , Marino-Martinez Ivan Alberto , Rivas-Estilla Ana María , Pérez-Maya Antonio Alí
Published: January 2023

Suicide is defined as the action of harming oneself with the intention of dying. It is estimated that worldwide one suicide occurs every 40 seconds, making it a major health problem. Studies in families have suggested that suicide has a genetic component, around the world studies have been carried out in search of genetic variants associated with suicidal behavior, these variants could be useful as potential biomarkers to identify people at risk of suicide. In this area in Mexico, some studies of variants in genes related to neurotransmission and other important pathways have been carried out and a possible association of variants located in genes has been suggested: SLC6A4, SAT-1, TPH-2, ANKK1, GSHR, SCARA50, RGS10, STK33, COMT, and FKBP5. This systematic review shows the genetic studies on the Mexican population. This article contributes by compiling the existing information on genetic variants and genes associated with suicidal behavior, said variants in the future could be used as potential biomarkers to identify people at risk of suicide.
Pyrolysis of Waste Biomass – Technical and Process Achievements, and Future Development – A Review
Authors: Igliński Bartłomiej , Kujawski Wojciech , Kiełkowska Urszula
Published: January 2023

Pyrolysis has been applied in the human economy for many years, and it has become a significant alternative to the production of chemical compounds, including biofuels. The article focuses mostly on recent achievements in the technical and processing aspects of pyrolysis. This review provides an overview of the recent advanced pyrolysis technology used in gas, bio-oil, and biochar production. The key parameters to maximize the production of specific chemical compounds were discussed and considered during the construction of the reactors. The emphasis is put on optimizing the process parameters, technical requirements, and renewable energy use in the process and conception to improve the efficiency of product production. The application of pyrolysis gas, oil, and biochar as valuable chemical compounds are related to the intensifying effects of climate change, biofuel production, and waste management in accordance with the principles of sustainable development.
Forgotten “Primum Non Nocere” and Increased Mortality after Covid-19 Vaccination
Authors: Šorli Srecko
Published: January 2023

Background The main reason for the worldwide massive covid vaccination in 2021 was to reduce the high mortality caused by the Covid-19 virus in 2020. It is time that in 2022 a rigorous analysis is done of the effectiveness of this massive vaccination. Methods In statistics, we have an accurate methodology to measure the impact of massive vaccination on public health. The mathematical relation between vaccinated/alive groups will be repeated between vaccinated/dead groups with high statistical certainty. This occurs because we are dealing with big numbers. Results Calculations were done for five periods of four weeks: weeks 35-38 (2021), weeks 39-42 (2021), weeks 43-46 (2031), weeks 47-50 (2021), and weeks 51(2021)-2(2022). Obtained results are confirming that the mortality of the vaccinated infected groups is higher on average by 14.5% than the mortality of non-vaccinated infected groups. Conclusions Results are suggesting the extension of the statistic between the vaccinated/alive group and the vaccinated/dead group for different age groups. These statistics will have higher statistical significance because of the elimination of the Simpson effect. Calculating the exact impact of covid-19 vaccination on the mortality rate is the necessary step to satisfy the first principle of medicine: “Primum non nocere”.
Morphological Medial Gastrocnemius Muscle Growth in Ambulant Children with Spastic Cerebral Palsy: A Prospective Longitudinal Study
Authors: De Beukelaer Nathalie , Vandekerckhove Ines , Huyghe Ester , Molenberghs Geert , Peeters Nicky , Hanssen Britta , Ortibus Els , Van Campenhout Anja , Desloovere Kaat
Published: January 2023

Only cross-sectional studies have demonstrated muscle deficits in children with spastic cerebral palsy (SCP). The impact of functional impairments on altered muscle growth remains unclear. This prospective longitudinal study modelled the morphological muscle growth in 87 children with SCP (age range 6 months to 11 years, Gross Motor Function Classification System [GMFCS] level I/II/III=47/22/18). Repeated ultrasound assessments were performed during 2-year (y) follow-up with an interval of minimal 6 months. Three-dimensional freehand ultrasound was applied to assess medial gastrocnemius muscle volume (MV), mid-belly cross-sectional area (CSA) and muscle belly length (ML). Non-linear mixed models compared trajectories of (normalized) muscle growth between GMFCS-I versus GMFCS-II&III. MV and CSA growth trajectories showed piecewise model with 2 breakpoints, with the highest growth before 2y and negative growth rates after 6-9y. Before 2y, children with GMFCS-II&III already showed lower growth rates compared to GMFCS-I. From 2-9y, the growth rates did not differ between GMFCS-levels. After 9y, a more pronounced reduction in normalized CSA was observed in GMFCS-II&III. Different trajectories in ML growth were shown between the GMFCS-level subgroups. These longitudinal trajectories could be used to monitor the SCP muscle pathology during childhood and to optimize treatment planning and goals aiming to stimulate muscle growth
The Upgraded Planck System of Units that Reaches from the Known Planck Scale All the Way Down to Subatomic Scales
Authors: Christodoulou Dimitris M. , Kazanas Demosthenes
Published: January 2023

Natural systems of units {Ui} need to be overhauled to include the dimensionless coupling constants {αUi} of the natural forces. Otherwise, they cannot quantify all forces of nature in a unified manner. Thus, each force must furnish a system of units with at least one dimensional and one dimensionless constant. We revisit three natural systems of units (atomic, cosmological, and Planck). The Planck system is easier to rectify, and we do so in this work. The atomic system discounts {G,αG}, thus it cannot account for gravitation. The cosmological system discounts {h,α**h**}, thus it cannot account for quantum physics. Here, the symbols have their usual meanings; in particular, αG is the gravitational coupling constant and α**h** is Dirac’s fine-structure constant. The speed of light c and the impedance of free space Z0 are resistive properties imposed by the vacuum itself, thus they must be present in all systems of units. The upgraded Planck system with fundamental units
The Study of Selection Bottle Packaging for Carbonated Beverages
Authors: Susanti Ari Diana , Jalesaputri Diaz Dzulriyana , Hasanah Fadhilah Rahmatul , Romadhoni Achmad Tegar , Gultom Alvin Petrus
Published: January 2023

The growth of the packaged beverages market in Indonesia is overgrowing. One sector of packaged beverages is carbonated beverages and bottled water. The main problem with packaged beverages containing dissolved gases is maintaining product quality during shelf life. Packaging materials and packaging lids cause a decrease in dissolved gas levels in beverages. Therefore, this study aims to analyze leaks in polyethylene terephthalate and glass bottles so that can use them to estimate the shelf life of the product. This study uses water, 3 types of glass bottles, and 1 type of plastic bottle. Bottles filled with water with various filling volumes of 40%v/v, 60%v/v, and 80%v/v were then analyzed for bottle leakage for 8 days. The results showed that effectively used a glass bottle with a volume of 250mL filled with more than 80%v/v, this was because it had the least leakage rate compared to others. In addition, this bottle has an attractive visual, easy labeling, and the size is not too large (ergonomic).
Effect of Acrylamide And Potassium Peroxodisulphate on The Quality of Bead Gel Based on Cassava Bagasse-Carrageenan Using Microwave Grafting Method
Authors: Distantina Sperisa , Hidayatun Nurul , Nabila Shifa Annisa , Kaavessina Mujtahid , Fadilah Fadilah
Published: January 2023

Hydrogels are widely used for drug delivery systems, immuno-chemotherapy applications, efficient use of water, preventing dry soil, and increasing soil infiltration. Generally, hydrogels are derived from synthetic polymers which is non-biodegradable and toxic. Cassava bagasse is an alternative cellulose to make hydrogels. The purpose of this research was to determine the effect of the amount of acrylamide and potassium peroxodisulphate (KPS) initiator on the quality of bead gel based on cassava bagasse-carrageenan. Chemical structure of the hydrogel was studied using FTIR spectroscopy. Cassava bagasse was immersed in a solution of n-hexane to separate the fat. Then, fat-free cassava bagasse was grafted with mass ratios of cassava and acrylamide 1:5, 1:10, and 1:15 in 110 mL water. The solution was added with a KPS initiator with weight variations (g) 0.04; 0.08; 0.12 then stirred 15 min. The solution was put in the microwave with 630 watts of irradiation for 450 s with the cooling cycle temperature maintained at 65-70oC. The aqueous of grafted polymer and carrageenan was injected into beaker glass that contained 1 cm of palm oil and mixture of 0.2 M CaCl2 and 0.2 M KCl in an ice bath. Results showed that the highest average swelling capacity was found in the bead gel variation 1:15 with the number of initiators 0.04 g of 1797.95% at a time of 210 minutes of immersion. From FTIR spectrum, it was found that there was a success in grafting acrylamide into bagasse’s backbone using the microwave grafting method with KPS as initiator.
Use of Judicial Bypass of Mandatory Parental Consent to Access Abortion and Judicial Bypass Denials, Florida and Texas, 2018–2021
Authors: Stevenson Amanda Jean , Coleman-Minahan Kate
Published: January 2023

Objectives. To describe minors’ use of judicial bypass to access abortion and the percentage of bypass petitions denied in Florida and Texas.

Methods. Data were derived from official state statistics on judicial bypasses and abortions by age in Texas and Florida; abortions in Texas among minor nonresidents were estimated. In addition, judicial bypass petitions as a percentage of abortions received by minors and judicial bypass denials as a percentage of petitions were calculated.

Results. Between 2018 and 2021, minors received 5527 abortions in Florida and an estimated 5220 abortions in Texas. Use of judicial bypass was stable at 14% to 15% in Florida and declined from 14% to 10% in Texas. Among petitions for judicial bypass, denials increased in Florida from 6% to a maximum of 13% and remained stable in Texas at 5% to 7%.

Conclusions. Minors’ use of judicial bypass in Texas and Florida is substantial. The percentage of denials is higher and increasing in Florida.

Public Health Implications. Minors who need confidential abortion care may now be forced to seek judicial bypass far from home. Parental involvement laws in states that do not ban abortion will compound barriers to abortion care. (Am J Public Health. 2023;113(3):316–319. https://doi.org/10.2105/10.2105/AJPH.2022.307173 )
Newly qualified teachers’ perceptions and experiences about portfolio assessment in Wa Municipality, Ghana
Authors: Akumdaare Atiah Paul
Published: January 2023

Portfolio assessment is a tool that enables professionals to reflect on their development. Despite the popularity of portfolio-based assessment among educators, little research has been conducted in Ghana to establish how newly trained teachers view portfolio assessment as a learning and assessment tool. A survey of newly qualified teachers was performed to learn about their experiences and perceptions of portfolio assessment as a tool for continuing professional development (CPD) and obtaining a full teaching license in Wa Municipality, Upper West Region of Ghana with a total population of 187. Out of the total population,58 newly qualified teachers (NQTs) were selected using a simple random sampling procedure. The researcher used a questionnaire as the predominant instrument to obtain data. Quantitative data were analyzed using descriptive statistics such as tables, charts, and bar graphs. Qualitative data were also analyzed using content analysis. This was based on analysis of meaning and implications emanating from the respondents’ information. The portfolio was deemed a good learning tool by the majority of the research participants, the newly qualified teachers. They did, however, believe that creating a proper portfolio is stressful and time-consuming. According to the study's findings, the system will not succeed unless students receive proper direction from academic professionals like National Teaching Council (NTC), in-service teachers, and headteachers, etc.
La evaluación del índice de área verde en los espacios públicos del distrito de Chorrillos
Authors:   , Antunez Paucara Yesenia Gladys Rosa , Díaz Condori Eva Marisol , Kuong Gago Sebastián Ricardo
Published: January 2023

Actualmente en Lima, es preocupante la escasa cantidad de áreas verdes urbanas existentes, es común ver espacios planificados que se encuentran en abandono. Si bien algunos estudios han investigado sobre el índice de superficie verde por habitante a un nivel distrital en Lima Metropolitana, no se han centrado en un análisis específico que ayude a la identificación de las zonas más problemáticas. Así como el distrito de Chorrillos que no cuenta con un análisis de la calidad de las áreas verdes urbanas ni cuánta cobertura se tiene frente a las edificaciones circundantes, para lo cual con la presente investigación tomamos como objetivo determinar la influencia de la calidad del espacio público y el índice de área verde en el sector de Delicias de Villa para conocer cómo se encuentran los parques urbanos. La metodología empleada es descriptiva donde se utilizó documentación, fichas de cotejo, mapas, fotografías e investigación en campo como instrumentos principales para la recolección de la información. Se obtuvo como conclusión que los espacios públicos de Delicias de Villa tienen un bajo índice de área verde con respecto a su mantenimiento que no satisface las necesidades de los habitantes en seguridad, accesibilidad y confort.
Efectividad del programa Fastrainer sobre la rapidez en residentes de Gineco-Obstetricia del Hospital Nacional Docente Madre Niño San Bartolomé, 2021
Authors:   , Alayo Sirlupu Fernando
Published: January 2023

El advenimiento de la laparoscopía ha supuesto, desde sus instancias iniciales, un reto para la formación quirúrgica, puesto que al ser una técnica que requiere de habilidades nuevas y complejas, incrementa el riesgo potencial de errores en la práctica en perjuicio del paciente en el contexto de un modelo de enseñanza tradicional, caracterizado por ser in situ en la sala de operaciones. La sociedad actual tiene menor tolerancia y condescendencia ante el error médico, lo que ha obligado a cambiar el paradigma de la educación quirúrgica, que llevaba un poco más de una centuria sin modificarse. El error médico es responsable de miles de muertes al año y de gastos millonarios, incluso en países desarrollados, que no se reportan con gran frecuencia y que permanecen ocultos por las implicancias legales y sociales que tiene. Según datos de la OMS, la probabilidad de morir por un error médico prevenible es de 1/300, y la inseguridad del paciente en el ambiente hospitalario es de tal magnitud que, al año en el mundo ocurren 134 millones de resultados adversos que derivan de errores en la atención médica y 2.6 millones de estos casos resultan fatales. Dentro del ambiente hospitalario, la sala de operaciones continúa siendo el lugar que origina altas tasas de morbilidad y mortalidad. Anualmente, se reportan 7 millones de pacientes quirúrgicos que desarrollan complicaciones, de los cuales 1 millón termina falleciendo en el periodo intraoperatorio o postoperatorio. Esto último refleja la inseguridad del paciente en la sala quirúrgica, quedando expuesto a la impericia de cirujanos principiantes, entre otros factores. Los errores que inciden con mayor frecuencia en el ámbito quirúrgico son los relacionados a una técnica defectuosa y a un mayor tiempo quirúrgico, los cuales se dan como consecuencia del cansancio, impericia, carencia de conocimientos y carencia de habilidades blandas.
Eficiencia de un biol elaborado a partir de residuos de cosecha en la producción del cacao (Theobroma cacao L.), clon TSH 565 en una plantación orgánica agroforestal
Authors:   , Lucano Lopez Diana Danet Casandra
Published: January 2023

Se evaluó la calidad y eficiencia de un biol elaborado a partir de residuos de cosecha de cacao sobre un clon de cacao fino de aroma (TSH-565) en una parcela con arreglo agroforestal, ubicada en el distrito de Campo Verde, región Ucayali. Se utilizó un diseño de bloques completos al azar con tres repeticiones y cinco tratamientos aplicados a nivel de copa de árbol. El tratamiento control consistió en una única aplicación de la fertilización que realiza el productor de 1 kg de gallinaza, 250 g roca fosfórica y 250 g de dolomita, el T1 en la aplicación de biol diluido en agua a una concentración de 10%, T2 al 15%, T3 al 20% y para el T4 se combinó biol al 15% adicionando la fertilización del productor. El biol elaborado posee un alto contenido nutricional de macro y micronutrientes (N, P, K, Ca, Mg), salinidad y huminas. El contenido de N y K en el suelo no evidenció una variación considerable entre tratamientos, a excepción del P donde si se observó incrementos. En temporada de sequía solo variables de peso, diámetro (T1 y T2) y cantidad de mazorcas (T4 y T2) fueron significativamente superiores (P<0,05). Con el inicio de lluvias no se evidenció efectos residuales significativos. Los rendimientos más altos para grano seco fueron obtenidos en T1 y T2 con 366 Kg/ha y 380 Kg/ha, siendo los más bajos en el control y T3 con 185 Kg/ha y 249 Kg/ha.
Brote de Acinetobacter baumannii extremadamente resistente a los antimicrobianos en una Unidad de Cuidados Intensivos de Neonatos en Lima
Authors:   , Galarza Vilchez Elka Lourdes , Vargas Meza Mary Elena
Published: January 2023

Objetivo: Caracterización de los genes implicados en la resistencia a carbapenémicos y la relación clonal de las cepas de Acinetobacter baumannii aisladas de neonatos del Instituto Nacional Materno Perinatal (INMP) de Lima en el período 2018-2019. Materiales y métodos: Estudio transversal de caracterización de cepas de A. baumannii en el periodo 2018-2019. Se incluyeron muestras de sangre, heces, líquido cefalorraquídeo y secreciones de pacientes internados en la Unidad de Cuidados Intensivos Neonatales e Intermedios (UCIN y UCI) del Instituto Nacional Materno Perinatal de Lima. Se evaluó la sensibilidad a antimicrobianos por método de difusión en disco y por microdilución para la evaluación de los niveles de sensibilidad a colistina. Se identificaron los genes codificantes para carbapenemasas mediante el uso PCR multiplex. La relación clonal se evaluó mediante REP-PCR. Resultados: Entre junio del 2018 y octubre del 2019 se analizaron 49 muestras de A. baumannii en neonatos en la UCIN y UCI. De todas las muestras, sólo se dispuso un total de 25 aislados para el estudio de clonalidad y de sensibilidad a colistina, de los cuales 23 (92%) resultaron ser extremadamente resistentes (XDR) y destacar 2 aislados (8%) Pandrogo resistente (PDR), al presentar una Concentración Mínima Inhibitoria (MIC) a colistina >2 mg/L. En todos los aislados de A. baumannii se detectó la presencia del gen blaOXA-24-like, responsable de la resistencia a carbapenémicos. El análisis de clonalidad identificó 3 patrones de resistencia en total, pero 20 (80%) de ellos presentaron el mismo patrón (patrón 01), mientras que 3 (12%) y 2 (8%) aislados presentaron el patrón 02 y 03 respectivamente. Conclusión: Se identificó un brote de A. baumannii XDR productoras de β-lactamasas OXA-24 en la UCIN del INMP durante el 2018-2019.
Benchmarking y su relación con las ventas en la Empresa Empaninos, Chorrillos - 2021
Authors:   , Ramírez Huaroto Yasmín Trinidad
Published: January 2023

El objetivo del estudio fue determinar la relación que existe entre el benchmarking y las ventas en la empresa Empaninos, Chorrillos – 2021. Esta investigación tuvo un diseño no experimental, tipo correlacional – descriptivo, corte transversal y enfoque cuantitativo. La muestra estuvo conformada por 80 clientes de la empresa. Los instrumentos obtuvieron un alfa de cronbach, de benchmarking (0.884) y ventas (0.904). Los resultados indicaron una relación positiva moderada, con un rs=0.630, siendo la prueba significativa con un pvalor=0.000 <0.05. Se concluyó que existe una relación directa entre el benchmarking y los niveles de ventas. Motivo por el cual mientras se aplique el benchmark de manera adecuada en los procesos comerciales, el nivel de ventas se incrementará como resultado.
Radios comunitarias y participación ciudadana en las zonas periurbanas del distrito de Ayacucho - 2018
Authors:   , Quispe Olano Jaime Grossby
Published: January 2023

La presente investigación expone el alcance de la radio comunitaria – voz vecinal como una herramienta para mejorar la participación ciudadana en la zona periurbana del distrito de Ayacucho, provincia de Huamanga, región de Ayacucho (Perú), impulsadas por la Subgerencia de Participación Vecinal de la Municipalidad Provincial de Huamanga. Se utilizaron como instrumentos metodológicos la observación, entrevistas a profundidad, cotejo de programas radiales, la “Escalera de Participación” de Hart para medir la participación y el modelo de la “Comunicación Horizontal” de Ramiro Beltrán. Recoge los consensos y disensos entre los pobladores, dirigentes y agentes de desarrollo (trabajadores, funcionarios y autoridades de la institución edil), así como las percepciones de estos sobre la participación comunitaria y ciudadana que se pudo fortalecer con el uso de altoparlantes para promover una experiencia de radio comunitaria similar a otras experiencias en Latinoamérica. Pone en relevancia el papel de promotor que cumple el gobierno local al instalar estos sistemas de comunicación analógica que permitieron empoderar al vecindario, atender sus problemas con la presencia de los representantes del gobierno local.
Comparative genomic analysis of five Coprinus species
Authors: Wang Jingjing , Zhang Ran , Ding Guoao , Wang Lingling , Wang Wei , Zhang Yan , Zhu GuiLan
Published: January 2023

Although Coprinus is widely known for the phenomenon of deliquescence and production of fungal laccases and extracellular peroxygenases, the genome structure and genetic diversity of Coprinus species have not been extensively studied. To reveal the genomic structure and diversity in Coprinus species, the genomes of five Coprinus species were compared and analyzed. A total of 24,303 orthologous gene families, including 89,462 genes, were identified in the five species. The numbers of core, softcore, dispensable, and private genes were 5617 (25.6%), 1628 (7.4%), 2083 (9.5%), and 12574 (57.4%), respectively. Differentiation time analysis revealed that Coprinellus micaceus and Coprinellus angulatus differentiated approximately 181.0 million years ago. Coprinopsis cinerea and Coprinopsis marcescibilis differentiated approximately 131.0 million years ago, and they were differentiated from Candolleomyces aberdarensis approximately 176.0 million years ago. Gene family contraction and expansion analyses showed that 1,465 genes and 532 gene families were expanded, and 95 genes and 134 gene families were contracted. Ninety-five laccase-coding genes were detected in the five species, and the distribution of the laccase-coding genes in the five species was not uniform. These data provide a reference for a deeper understanding of the genetic structure of the genomes of Coprinus species. Furthermore, this study provides a reference for follow-up studies on the genome structure of Coprinus species and the diversity of specific functional genes.
Study of substrata of a slope susceptible to landslide in hilly environment using a geophysical method in The Nilgiris, India
Authors: Balakrishnan Mathangi , Zaalishvili Vladislav Borisovich , Ganapathy Ganapathy Pattukandan
Published: January 2023

Landslides are one of the prevailing threats to life that causes huge loss to the environment. Around 3.7 million km2 of the area is exposed to landslides globally and 820,000 km2 is at high risk for landslides in India. The major triggering factors of landslide in India are rainfall and earthquake. The Nilgiris district which is located in the south-western part of India is more prone to rainfall induced landslides. This study intends to calculate the depth of the slip surface on the slope (Lovedale area, The Nilgiris) in the event of a future landslide using Multichannel Analysis of Surface Waves (MASW). During November 2009 rainfall, a shallow landslide occurred at the toe of this particular slope. Hence, there are more probability for re-occurrence of landslide in the event of rainfall. The shear wave velocity (Vs) obtained from MASW was useful in understanding the variation of the sub-strata and predicting the depth of potential failure surface. The elastic moduli of the soil calculated using empirical relations and software, were compared and one reliable method was considered. The MASW results can be further used for analysing the stability of the slope, reactivation of landslides and landslide early warning system.
Gray Level Co-occurrence Matrix with Binary Robust Invariant Scalable Keypoints for Detecting Copy Move Forgeries
Authors: Singh Amarpreet , Singh Sanjogdeep
Published: January 2023

With advancement in technology, especially in imaging field, digital image forgery has increased a lot nowadays. In order to counter this problem, many forgery detection techniques have been developed from time to time. Copy Move Forgery is one such technique which is applied in conjunction with various other techniques to find forged regions within an image. For rapid and accurate detection of forged image, a novel hybrid technique is used in this research work that implements Gray Level Co-Occurrence Matrix (GLCM) along with Binary Robust Invariant Scalable Keypoints (BRISK). GLCM significantly extracts key attributes from an image efficiently which will help to increase the detection accuracy. BRISK is known to be one of the 3 fastest modes of detection which will increase the execution speed of GLCM. BRISK even processes scaled and rotated images. Then the Principal Component Analysis (PCA) algorithm is applied in the final phase of detection will remove any unrequited element from the scene and highlights the concerned forged area.
Tumor hypoxia promotes MAPK signaling by inhibiting prolyl hydroxylation of SOS1
Authors: Yuan Lin , Lv Guoqing , Chen Hebing , Ren Caixia , Ye Qiao , Li Hao , Kong Xiangzhen , Li Xi , Cao Xiaolong , Zhang Jinlu , Wen Hanlu , Tian Qin , Yang Jingyi , You Fuping
Published: January 2023

The hypoxic tumor microenvironment promotes both cancer progression and drug resistance.Prolyl hydroxylases are hypoxic sensor proteins that are frequently mutated or heterozygously deleted in breast cancers; however, how prolyl hydroxylation regulates breast cancer progression and drug resistance remains poorly understood. Here, we found that hypoxia promotes cancer progression and resistance to chemotherapy drugs, specifically through prolyl hydroxylation-dependent activation of MAPK signaling. We characterized a pVHL-independent mechanism wherein the prolyl hydroxylase EglN1 catalyzed prolyl hydroxylation of the proline-rich domain of RAS-specific guanine nucleotide exchange factor SOS1, thereby preventing its binding with the growth factor receptor bound protein 2 (GRB2) to block the formation of MAPK signaling microclusters in breast cancer. Inhibition of EglN1’s prolyl hydroxylase function—which occurs in hypoxic conditions and upon accumulation of fumarate—induced cancer-specific dysregulation of MAPK signaling, which promoted both breast cancer growth and resistance to MEK inhibitors. We harnessed this insight and demonstrated a therapeutic strategy that potently inhibits breast cancer growth and drug resistance based on pharmacologically disrupting the prolyl-hydroxylation-mediated interaction between SOS1 and GRB2.
Psychometric Properties of the Brief Life Skills Scale for Adolescents (EHV-A)
Authors: González-Forteza Catalina , A. Patricia María del Carmen Fuentes , Cortés Eunice Ruiz , Castro Julio César Flores , Benjamin Rafael Gutiérrez , Tapia Alberto Jiménez
Published: January 2023

Background: Life skills are important resources for adolescents to strengthen their psychosocial development. The objective of this study was to build and validate an instrument for assessing a number of life skills in adolescents.
Method: The Brief Life Skills Scale for Adolescents (EHV-A) was designed using psychometric tests validated for Mexican adolescents, including those items with the best psychometric values. It was administered to 4008 students. Analysis of the internal structure of the test was performed using an exploratory factor analysis (EFA) with oblique rotation and a confirmatory factor analysis (CFA) to corroborate the theoretical consistency of the model. Reliability was estimated using Cronbach's alpha. Concurrent validity was measured with a brief version of the Rosenberg Self-Esteem Scale.
Results: The EFA model generated a structure of six components that explained 67% of the variance. This structure was corroborated by the CFA. The model had adequate fit indices and the concurrent validity test of the EHV-A was acceptable and theoretically consistent.
Conclusions: The results show satisfactory psychometric properties and the convergent validity of the EHV-A, demonstrating that it is a potentially useful tool for assessing life skills in adolescents.
Report and follow-up on two new patients with Congenital Mesoblastic Nephroma
Authors: Serra Gregorio , Cimador Marcello , Giuffrè Mario , Insinga Vincenzo , Montante Claudio , Pensabene Marco , Piro Ettore , Salerno Sergio , Schierz Ingrid Anne Mandy , Corsello Giovanni
Published: January 2023

Background
Tumors are rare in neonatal age. Congenital mesoblastic nephroma (CMN) is a usually benign renal tumor observed at birth, or in the first months of life. It may also be identified prenatally, and associated with polyhydramnios leading to preterm delivery. Effective treatment is surgical in most cases, consisting in total nephrectomy. In literature, very few studies report on the neonatal management of such a rare disease, and even less are those describing its uncommon complications.
Cases presentation
We report on two single-center newborns affected with CMN. The first patient is a preterm female baby, born at 30+1 weeks of gestation (WG) due to premature labor, with prenatal (25 WG) identification of an intra-abdominal fetal mass associated with polyhydramnios. After that clinical stability, weight gain, instrumental (computed tomography, CT, showing a 4.8 x 3.3 cm left renal neoformation) and histological/molecular characterization of the lesion (renal needle biopsy picture of classic CMN with ETV6-NTRK3 translocation) were obtained, a left nephrectomy was performed at 5 weeks of chronological age. The following clinical course was complicated by intestinal obstruction due to bowel adherences formation, and then by an enterocutaneous fistula, requiring multiple surgical approaches including transitory ileo- and colostomy, before the conclusive anastomoses intervention. The second patient is a 17-day-old male term baby, coming to our observation due to postnatal evidence of palpable left abdominal mass (soon defined through CT, showing a 7.5 x 6.5 cm neoformation in the left renal lodge), feeding difficulties, and poor weight gain. He then developed hypertension and hypercalcemia, needing intravenous diuretic treatment and which regressed after nephrectomy (histological diagnosis of cellular CMN with ETV6-NTRK3 fusion), performed at day 26. In neither case was chemotherapy added. Both patients have been included in multidisciplinary follow-up, and presently show regular growth and neuromotor development, normal renal function and no local/systemic recurrences or other gastrointestinal/urinary disorders.
Conclusions
The finding of a fetal abdominal mass should prompt suspicion of CMN, especially if it is associated with polyhydramnios, and alert obstetricians and neonatologists also for the risk of preterm delivery. Although being a usually benign condition, CMN may be associated with neonatal systemic-metabolic or postoperative complications. High-level surgical expertise, careful neonatological intensive care, and histopathological/cytogenetic-molecular definition are the cornerstones for the optimal management of patients. This should also include an individualized follow-up, oriented to early detection of any possible recurrences or associated anomalies, and to improve the quality of life of these children and their families.
Influence of maternal oral microbiome on newborn oral microbiome in healthy pregnancies
Authors: Russo Monica , Calevo Maria Grazia , D’Alessandro Gloria , Tantari Matteo , Migliorati Marco , Piccardo Ilaria , Perucchin Paola Polo , Arioni Cesare
Published: January 2023

BACKGROUND Periodontal disease and its bacteria can be responsible for pregnancy complications and transmission of periodontal bacteria from mother to newborn.
PATIENTS AND METHODS A salivary swab to 60 healthy, full-term newborns and their mothers was taken immediately after birth. The test was performed with Real Time PCR method to evaluate the expression of the gene through DNA amplification. The species considered were: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum ssp.
RESULTS The newborn oral microbiome was composed primarily by saprophytes (98.38+4.88%), just like the mothers (98.8+3.69%). There was a statistically significant difference of the total microbiological density in newborns and mothers (p=0.0001). Maternal and neonatal oral microbiome had a correlated total microbiological density only in 33.3% (N=20/60) of cases. The analysis of the oral microbiome showed a pathological composition only in 12/60 babies (20%). The most frequent detected specie in newborns was Fusobacterium nucleatum (9/12 babies, 75%), as well as for the mothers (53.3%). However, the pathogen was present both in baby and his mother only in 3 dyads. Porphyromonas gingivalis showed the highest association mother-baby (4/12 dyads, 33%). Porphyromonas gingivalis was the pathogen with the highest bacterial load in the 12 mothers. We found a statistically significant difference in the total load of Porphyromonas gingivalis in mothers and babies (p=0.02).
DISCUSSION There was a statistically significant difference in the richness of the microbiome from newborns and mothers. Even comparing the microbiological density in the oral cavity of the individual mother-child pairs, we did not find a significant concordance. These results seem to suggest a low influence of maternal oral microbiome on the richness of the oral neonatal one. We didn’t find mother-child concordance (p=0.0001) in the presence of pathogenic periodontal micro-organisms. Fusobacterium nucleatum was the most frequent specie detected. Porphyromonas gingivalis instead was the bacteria with the higher possibility of transmission.
CONCLUSIONS In our study maternal oral health doesn’t affect healthy, full-term newborns’ oral microbiome. Further studies are needed to understand the maternal influence on newborn’s oral microbiome and its effects on babies long-term health.
HIV-1 infection reduces NAD capping of host cell snRNA and snoRNA
Authors: Benoni Barbora , Benoni Roberto , Trylcova Jana , Grab Katarzyna , Paces Jan , Weber Jan , Stanek David , Kowalska Joanna , Bednarova Lucie , Keckesova Zuzana , Gahurova Lenka , Cahova Hana
Published: January 2023

NAD is a key component of cellular metabolism and also serves as an alternative 5’cap on short noncoding RNAs. The function of NAD in RNA, however, remains poorly understood. We investigated NAD capping of RNAs in HIV-1 infected cells, as HIV-1 is responsible for the depletion of the NAD/NADH cellular pool and causes intracellular pellagra. We used NAD captureSeq on HIV-1 infected/noninfected cells and revealed that four snRNAs (U1, U4ATAC, U5E, and U7) and four snoRNAs (SNORD3G, SNORD102, SNORA50A, and SNORD3B) lost their NAD cap when infected with HIV-1. Here, we provide evidence that the loss of the NAD cap increases the stability of the U1-HIV-1 pre-mRNA duplex. We also show that decreasing the amount of NAD-capped U1 snRNA by overexpressing the NAD RNA decapping enzyme DXO leads to a marked increase in HIV-1 infectivity. Moreover, an experimental increase of NAD capped RNAs improves the efficiency of splicing of HIV-1 and cellular RNAs and lowers HIV-1 infectivity. Our experiments show a potential dual role of U1 snRNA in HIV-1 infection and present the first possible function of NAD-capped RNAs in eukaryotic antiviral responses.
Bifurcations and limit cycle prediction of rotor systems with fluid-film bearings using Spectral Submanifolds
Authors: Mereles Arthur Guilherme , Alves Diogo Stuani , Cavalca Katia Lucchesi
Published: January 2023

Many rotating machines utilize a fluid type bearing. Despite their reliability and high load capacity, these bearings often show instabilities due to the interaction between the fluid media and the rotating shaft. These instabilities, known as oil-whirl and oil-whip, occur due to a Hopf bifurcation; being the parameter the shaft speed. Identifying the type of bifurcation, either sub-critical or super-critical, is an important task to determine the safety of the machines near the instability speed. This work presents an approach, labeled Center Spectral Submanifold (CSSM), to obtain limit cycles near Hopf bifurcations of rotors supported on fluid-film bearings. The basis of the method is the obtention of the center manifold of the system, which allows one to assess the type of bifurcation at hand. The CSSM is based on the idea of Spectral Submanifolds (SSMs) and the parameterization method, and it's a powerful tool to analyze the bifurcation of high-dimensional rotor systems. The method is evaluated by comparing its results with an open-source numerical continuation package (MATCONT) in two systems: a simple and a realistic rotor system. The results show that the CSSM can be used reliably to learn if the rotor system presents sub- or super-critical bifurcations, to perform parametric studies with different bearing properties and also to predict the amplitude of the limit cycles.