bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Potential of Rosa davurica Pall. Root Extract as an Antidiabetic Agent: A Comprehensive Analysis from Molecular Mechanisms to In Vivo Efficacy
Authors: Hwang Du Hyeon , Asirvatham Ravi Deva , Mohan Prakash Ramachandran Loganathan , Kang Changkeun , Kim Euikyung
Published: August 2024

Rosa davurica Pall. is widely used in traditional oriental herbal therapy, but its components and molecular mechanisms of action remain unclear. This study investigates the antidiabetic potential of Rosa davurica Pall. root extract (RDR) and elucidates its underlying molecular mechanisms with in vitro and in vivo models. Data from the current study show that RDR exhibits strong antioxidant activity and glucose homeostasis regulatory effects. It significantly impacts glucose homeostasis in C2C12 skeletal muscle cells by inhibiting α-glucosidase activity. Further molecular mechanistic studies revealed that RDR promoted glucose uptake by phosphorylation of AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC), but not Phosphatidylinositol 3-kinase (PI 3-kinase)/Akt in C2C12 skeletal muscle cells. These actions increased the expression and translocation of glucose transporter type 4 (GLUT4) to the plasma membrane. In addition, RDR treatment in the STZ-induced diabetic rats remarkably improved the low body weight, polydipsia, polyphagia, hyperglycemia, and islet architecture and increased the insulin/glucose ratio. The liver (ALT and AST) and kidney marker enzyme (BUN and creatinine) levels were restored by RDR treatment as well. Phytochemical analysis identified eight major constituents in RDR, crucial for its antioxidant and antidiabetic activity. Through the molecular docking of representative glucose transporter GLUT4 with these compounds, it was confirmed that the components of RDR had a significantly high binding score in terms of structural binding. These findings from the current study highlight the antidiabetic effects of RDR. Collectively, our data suggest that RDR might be a potential pharmaceutical natural product for diabetic patients.
Correlation of Road Safety Criteria with Occupant Safety Criteria in Impacts on Crash Cushions
Authors: Tomasch Ernst , Gstrein Gregor
Published: August 2024

Road restraint systems are used to protect vehicle occupants if the vehicle runs off the road and potentially collides with a dangerous obstacle. These road restraint systems must successfully pass the tests defined in EN 1317, or the Manual for Assessing Safety Hardware (MASH) before they are allowed to be installed. The safety assessment is carried out according to the criteria of ASI (Acceleration Severity Index), THIV (Theoretical Head Impact Velocity), OIV (Occupant Impact Velocity), ORA (Occupant Ridedown Acceleration), and PHD (Post-Impact Head Deceleration). Usually very old vehicles are used for these tests, and there is no assessment of occupant criteria such as HIC (Head Injury Criteria), chest deflection, etc. The objective of the study was to compare the occupant safety of vehicles that are commonly used in EN 1317 with vehicles that have improved safety equipment. Test results from two different vehicles (a commonly used vehicle in EN 1317 and a vehicle with improved safety equipment) and two different impact conditions (full overlap and an overlap of 50%) were compared. Measurement data from a Hybrid HIII 50th percentile anthropomorphic test device (ATD) (Denton ATD, INC.) was recorded during the tests to assess occupant safety. The tests have shown that vehicles with improved safety equipment perform better than vehicles that are commonly used in EN 1317-3 tests. The values for the occupant safety criteria assessed were well below the Euro NCAP (New Car Assessment Programme) or Federal Motor Vehicle Safety Standard (FMVSS) limits. However, the limits of the road safety criteria were in some cases considerably exceeded regardless of the vehicle. This has been observed in particular for the offset impact condition. THIV and OIV were supposed to be able to assess the risk of head injuries. However, these two criteria correlated negatively with the head criteria, HIC or a3ms. However, a positive correlation was found for the ASI with the HIC and the a3ms head acceleration. Even if some of the criteria for road safety correlate with the criteria for occupant safety, it is doubtful whether the criteria for road safety are suitable for assessing the risk of injury to vehicle occupants.
Technical Requirements of Photovoltaic Inverters for Low Voltage Distribution Networks
Authors: Chmielowiec Krzysztof , Topolski Łukasz , Dutka Mateusz , Piszczek Aleks , Hanzelka Zbigniew , Rodziewicz Tomasz
Published: August 2024

The paper presents the results of an experimental study, which was conducted in 2021 and briefly presented at the conference CIGRE Paris Session 2022, as a part of a joint initiative for comparative studies of PV inverters, of AGH University of Science and Technology and Tauron Dystrybucja (Polish DSO). The study was performed on a representative sample of 29 brand new PV inverters, widely available for sale in the EU, from over 20 various manufacturers from and outside the EU. For the purposes of this research, all tested PV have been made available by their manufacturers or regional distributors, which confirms the origin of the devices from official distribution channels and their designation for the EU market. The conducted research covers the technical aspects of PV inverters’ operation and performance included in the NC RfG network code, technical standard EN-505049-1:2019, and internal regulations of distribution system operators governing PV inverter technical quality and its cooperation with the low-voltage distribution network. The national regulations may differ between individual EU member states. The paper describes the testing procedure, obtained results, conclusions, and recommendations for regulatory bodies and DSOs.
Analyzing Dropout in Alcohol Recovery Programs: A Machine Learning Approach
Authors: Collin Adele , Ayuso-Muñoz Adrián , Tejera-Nevado Paloma , Prieto-Santamaría Lucía , Verdejo-García Antonio , Díaz-Batanero Carmen , Fernández-Calderón Fermín , Albein-Urios Natalia , Lozano Óscar M. , Rodríguez-González Alejandro
Published: August 2024

Background: Retention in treatment is crucial for the success of interventions targeting alcohol use disorder (AUD), which affects over 100 million people globally. Most previous studies have used classical statistical techniques to predict treatment dropout, and their results remain inconclusive. This study aimed to use novel machine learning tools to identify models that predict dropout with greater precision, enabling the development of better retention strategies for those at higher risk. Methods: A retrospective observational study of 39,030 (17.3% female) participants enrolled in outpatient-based treatment for alcohol use disorder in a state-wide public treatment network has been used. Participants were recruited between 1 January 2015 and 31 December 2019. We applied different machine learning algorithms to create models that allow one to predict the premature cessation of treatment (dropout). With the objective of increasing the explainability of those models with the best precision, considered as black-box models, explainability technique analyses were also applied. Results: Considering as the best models those obtained with one of the so-called black-box models (support vector classifier (SVC)), the results from the best model, from the explainability perspective, showed that the variables that showed greater explanatory capacity for treatment dropout are previous drug use as well as psychiatric comorbidity. Among these variables, those of having undergone previous opioid substitution treatment and receiving coordinated psychiatric care in mental health services showed the greatest capacity for predicting dropout. Conclusions: By using novel machine learning techniques on a large representative sample of patients enrolled in alcohol use disorder treatment, we have identified several machine learning models that help in predicting a higher risk of treatment dropout. Previous treatment for other substance use disorders (SUDs) and concurrent psychiatric comorbidity were the best predictors of dropout, and patients showing these characteristics may need more intensive or complementary interventions to benefit from treatment.
Preoperative OCT Characteristics Contributing to Prediction of Postoperative Visual Acuity in Eyes with Macular Hole
Authors: Mase Yoko , Matsui Yoshitsugu , Imai Koki , Imamura Kazuya , Irie-Ota Akiko , Chujo Shinichiro , Matsubara Hisashi , Kawanaka Hiroharu , Kondo Mineo
Published: August 2024

Objectives: To develop a machine learning logistic regression algorithm that can classify patients with an idiopathic macular hole (IMH) into those with good or poor vison at 6 months after a vitrectomy. In addition, to determine its accuracy and the contribution of the preoperative OCT characteristics to the algorithm. Methods: This was a single-center, cohort study. The classifier was developed using preoperative clinical information and the optical coherence tomographic (OCT) findings of 43 eyes of 43 patients who had undergone a vitrectomy. The explanatory variables were selected using a filtering method based on statistical significance and variance inflation factor (VIF) values, and the objective variable was the best-corrected visual acuity (BCVA) at 6 months postoperation. The discrimination threshold of the BCVA was the 0.15 logarithm of the minimum angle of the resolution (logMAR) units. Results: The performance of the classifier was 0.92 for accuracy, 0.73 for recall, 0.60 for precision, 0.74 for F-score, and 0.84 for the area under the curve (AUC). In logistic regression, the standard regression coefficients were 0.28 for preoperative BCVA, 0.13 for outer nuclear layer defect length (ONL_DL), −0.21 for outer plexiform layer defect length (OPL_DL) − (ONL_DL), and −0.17 for (OPL_DL)/(ONL_DL). In the IMH form, a stenosis pattern with a narrowing from the OPL to the ONL of the MH had a significant effect on the postoperative BCVA at 6 months. Conclusions: Our results indicate that (OPL_DL) − (ONL_DL) had a similar contribution to preoperative visual acuity in predicting the postoperative visual acuity. This model had a strong performance, suggesting that the preoperative visual acuity and MH characteristics in the OCT images were crucial in forecasting the postoperative visual acuity in IMH patients. Thus, it can be used to classify MH patients into groups with good or poor postoperative visual acuity, and the classification was comparable to that of previous studies using deep learning.
Demineralized Dentin Matrix Incorporated with rhBMP-2 Composite Graft for Treating Medication-Related Osteonecrosis of the Jaw
Authors: Ku Jeong-Kui , Choi Jin-Won , Song Seung-Min , Yun Pil-Young , Um In-Woong , Leem Dae Ho
Published: August 2024

Medication-Related Osteonecrosis of the Jaw (MRONJ) is characterized by bone exposure in the oral and maxillofacial region for more than eight weeks in patients treated with anti-resorptive agents, immunosuppressants, or anti-angiogenic agents, without prior radiation therapy or metastatic disease to the jaws. Conservative treatments can control infection in mild cases, but surgical intervention is necessary for patients with severe symptoms. A 78-year-old female with a history of bisphosphonate treatment for osteoporosis presented with persistent pain, swelling, and malodor following implant placement in the upper right maxilla. SPECT/CT imaging revealed a high-risk hot spot in the right maxillary region. BIS-guided surgery using the Qray pen-C was performed, selectively removing red fluorescent bone tissue. The defect was grafted with HuBT incorporated with rhBMP-2. Postoperative follow-ups at 4, 7, and 14 months showed successful bone healing, transforming into a corticocancellous complex, and implant placement without MRONJ recurrence. Allogeneic demineralized dentin matrix (DDM) incorporated with rhBMP-2 demonstrates effective bone healing and implant placement following BIS-guided MRONJ surgery. This case supports the use of DDM/rhBMP-2 for tissue regeneration in MRONJ treatment, enabling successful prosthetic restoration without recurrence.
Population Norms for Hand Grip and Precision Grip Strengths in Polish Children and Adolescents Aged 3–19
Authors: Górecki Michał , Kazarców Marta , Protasewicz Agnieszka , Czarnecki Piotr , Romanowski Leszek
Published: August 2024

Background: Normative data on hand and precision grip strengths are essential for evaluating the level of development, the efficacy of rehabilitation, and treatment results. The need for established norms of grip strength in Polish children is one of the problems that Polish physiotherapists and physicians face when treating upper limbs. The aim was to establish normative values of hand and precision grips strengths in Polish children and adolescents aged 3–19. Methods: In the years 2012–2023, a sample of 358 children and adolescents with no history of upper limb injuries or congenital upper extremity defects were randomly chosen from kindergartens, primary schools, middle schools, and high schools. They were living in urban agglomerations and in smaller towns or villages. Hand and precision grips like the pincer, three-point, side, and opposition grip strength were assessed using a hand dynamometer and pinchmeter in standard positions. Results: The strength in all types of examined hand grips increases with chronological age in both genders. The grip strength was higher in the boys’ group than in the girls’ and it was higher in the right hand than in the left, but the difference was no more greater than 10%. Detailed data with standard deviation were presented in the form of a table, divided by age and sex. Conclusions: Norms for grip strength were provided for Polish children and adolescents aged 3–19, allowing therapists and physicians to compare Polish patients with that of normally developed, healthy children of the same age and sex.
Omalizumab and Dupilumab for the Treatment of Bullous Pemphigoid: A Systematic Review
Authors: Granados-Betancort Elena , Sánchez-Díaz Manuel , Muñoz-Barba Daniel , Arias-Santiago Salvador
Published: August 2024

Background: Bullous pemphigoid (BP) is an autoimmune disease characterized by the appearance of very pruritic subepidermal blisters. It appears mostly in the elderly and is associated with multiple comorbidities, which makes its management and treatment difficult. The purpose of this systematic review is to compile current information on published cases of BP treated with omalizumab (omalizumab) and dupilumab (dupilumab) in order to obtain information on clinical efficacy and safety data available. Methods: A literature search of all cases of BP treated with omalizumab/dupilumab published in the literature up to January 2024 was performed using the Pubmed database. After an exhaustive search, a total of 61 studies encompassing 886 patients met the inclusion criteria and were included in the review. Results: The majority of patients with BP treated with omalizumab/dupilumab presented a significant improvement in symptomatology, being very safe drugs with minimal side effects. The main limitation of the presented review is the quality of the included studies, most of them being case series or individual cases. The development of studies with a higher level of scientific evidence in the near future would be of great interest. Conclusions: Both omalizumab and dupilumab appear to be effective options for treating BP in patients refractory to other pharmacological therapies. They are drugs with a good safety profile and the adverse reactions associated with their use are infrequent and generally mild.
The Impact of Liver Steatosis on Interleukin and Growth Factors Kinetics during Chronic Hepatitis C Treatment
Authors: Radmanic Matotek Leona , Zidovec-Lepej Snjezana , Salek Nikolina , Vince Adriana , Papic Neven
Published: August 2024

Background/Objectives: Various biological response modifiers play important roles in the immunopathogenesis of chronic hepatitis C (CHC). While serum levels of cytokines and growth factors change with the disease severity and treatment responses, the impact of concomitant liver steatosis on systemic inflammatory response is largely unknown. The aim of this study was to analyze the characteristics and kinetics of serum profiles of interleukins and growth factors in CHC patients with steatotic liver disease (SLD). Methods: Serum concentrations of 12 cytokines (IL-5, IL-13, IL-2, IL-6, IL-9, IL-10, IFN-γ, TNF-α, IL-17A, IL-17F, IL-4 and IL-22) and 6 growth factors (Angiopoietin-2, EGF, EPO, HGF, SCF, VEGF) were analyzed in 56 CHC patients at four time points (baseline, week 4, week 8 and SVR12) with bead-based flow cytometry assay. Results: At baseline, patients with SLD had significantly lower IL-9, IL-10, IL-13 and IL-22 and higher serum concentrations of EGF, VEGF and ANG. In a subgroup of patients with advanced liver fibrosis, SLD was linked with lower serum concentrations of IL-4, IL-5, IL-9, IL-10, IL-13 and IL-22 and higher concentrations of HGH and VEGF. Distinct cytokine kinetics during DAA treatment was observed, and SLD was identified as the main source of variation for IL-5, IL-9, IL-10, IL-13, IL-17A, IL-22, EGF, VEGF and ANG. Patients with SLD at SVR12 had significantly higher VEGF and HGF serum concentrations. Conclusions: SLD is associated with distinct cytokine and growth factor profiles and kinetics during CHC treatment, which might be associated with disease severity and the capacity for liver regeneration and contribute to fibrosis persistence.
A Review of the Current State of Research and Future Prospectives on Stimulus-Responsive Shape Memory Polymer Composite and Its Blends
Authors: Sanaka Rajita , Sahu Santosh Kumar , Sreekanth P. S. Rama , Senthilkumar K. , Badgayan Nitesh Dhar , Siva Bathula Venkata , Ma Quanjin
Published: August 2024

Shape-memory polymers (SMPs) possess unique properties that respond to external stimuli. The current review discusses types of SMPs, fabrication methods, and the characterization of their mechanical, thermal, and shape recovery properties. Research suggests that SMP composites, when infused with fillers, demonstrate enhanced mechanical and thermal characteristics. On the other hand, blends, particularly incorporating polylactic acid (PLA), exhibit the most efficient shape recovery. Furthermore, the crosslinking density in polymer blends impacts the shape recovery force, showcasing a correlation between energy storage capacity and shape recovery force in SMP networks. Overall, SMP blends show promising mechanical, thermal, and shape recovery features, rendering them advantageous for applications of artificial muscles, soft actuators, and biomedical devices. This review also discusses the future prospectives of SMP for robust applications.
Determining the Advanced Frequency of Composited Functionally Graded Material Plates Using Third-Order Shear Deformation Theory and Nonlinear Varied Shear Coefficients
Authors: Hong Chih-Chiang
Published: August 2024

The shear effect is usually considered in the numerical calculation of thick composited FGM plates. The characteristics that have the greatest effect on thickness are displacement type, shear correction coefficient, material property and temperature. For the advanced frequency study of thick composited functionally graded material (FGM) plates, it is interesting to consider the extra effects of the nonlinear coefficient c1 term of the third-order shear deformation theory (TSDT) of displacement on the calculation of varied shear correction coefficients. The values of nonlinear shear correction coefficients are usually functions of c1, the power-law exponent parameter and environment temperature. Numerical frequency computations are calculated using a simple homogeneous equation, and are investigated using TSDT and the nonlinear shear correction coefficient for thick composited FGM plates. Results for natural frequencies are found via the functions of length-to-thickness ratio, the power-law exponent parameter, c1 and environment temperature. This novel study in advanced frequency aims to determine the effects of the TSDT and nonlinear shear correction on thick FGM plates under free vibration.
General Anesthesia Improves Efficiency of High-Power Short-Duration Catheter Ablation for Atrial Fibrillation: Comparison with Mild Conscious Sedation
Authors: Minciună Ioan-Alexandru , Tomoaia Raluca , Suceveanu Mihai , Cismaru Gabriel , Puiu Mihai , Roșu Radu , Simu Gelu , Irimie Diana Andrada , Frîngu Florina , Caloian Bogdan , Andronache Marius , Zdrenghea Dumitru , Pop Dana
Published: August 2024

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia globally. High-power, short-duration radiofrequency (RF) catheter ablation (CA) for AF has recently emerged, reducing ablation times and enhancing patient tolerability with comparable efficacy and safety. While the benefits of general anesthesia (GA) for standard-power, standard-duration CA are well-established, data comparing GA to mild conscious sedation (MCS) for high-power, short-duration CA are limited. Methods: We included patients undergoing high-power, short-duration CA for AF under GA (group 1) or MCS (group 2). Procedural characteristics, success rates, and mid-term outcomes were compared. Results: In total, 131 patients, 47 in the GA group and 84 in the MCS group, were included. CA was performed for paroxysmal AF in 34 patients in group 1 (72.3%) and 68 patients in group 2 (80.9%). We found lower a mean total procedure time (100 [90–120] vs. 160 [130–180] min, p < 0.0001), lower radiation exposure (932.5 [625–1716] vs. 2445 [1228–4791] μGy, p < 0.0001 and 4.5 [3–7.1] 7.3 [4.2–13.5] min, p = 0.0003) and fewer RF applications (71 [54.8–83.8] vs. 103 [88.5–120.5], p < 0.0001) in the GA group. No major complications occurred. The 6-month AF recurrence rate was comparable between the groups (21.2% vs. 33.3%, p = 0.15). Conclusion: In patients undergoing high-power, short-duration RFCA for AF, the use of GA is associated with better procedural efficiency while simultaneously associated with an early recurrence rate comparable to MCS.
Monitoring of Open-Pit Mining Areas Using Landsat Series Imagery (1984–2023) and Cloud Processing
Authors: Montero Pau , Bustos Edgardo , Padró Joan-Cristian , Carabassa Vicenç
Published: August 2024

While open-pit mining activities represent one of the human-derived most impactful land cover changes, these changes and the linked restoration processes can be challenging to assess. This article presents a reproducible methodology carried out with cloud processing of satellite images (Google Earth Engine (GEE)) to evaluate the evolution of open-pit mining activities and their restoration in a Mediterranean landscape. For this purpose, the calculation of the normalized differential vegetation index (NDVI) was used to obtain a quantitative parameter to monitor vegetation presence in each extractive area. To validate these results, confusion matrices were performed between the classification obtained in the study and the official land cover mapping, using randomly selected mining areas as test points, with an average accuracy of 88%. According to the methodology used, the surface of areas denuded by mining in the period 1984–2023 has fluctuated over time, with a maximum in 2005 coinciding with the peak of the Spanish construction boom, and a subsequent decrease towards the present. From these results, it can be concluded that Landsat-type data processed using GEE provide a quick and useful tool for monitoring the evolution of mining activity, including restoration trends, becoming particularly valuable for public bodies’ inspections or decision making.
Revisiting the Conceptual Terrains of the Right to Accessibility in India: The Role of Judicial Enforcement
Authors: Jain Sanjay , Jain Malika
Published: August 2024

The main objective of this paper is to critically reflect on the right to accessibility of persons with disabilities in India, with special focus on the context of public streets and environments. The paper draws on work carried out during the India-related part of the Inclusive Public Space Project, as well as judicial pronouncements, and the norms evolved by India as a party to the United Nations Convention on the Rights of Persons with Disabilities. In this paper, we briefly set out competing conceptions of accessibility and evaluate its constitutional and statutory manifestations. Further, the measures undertaken by the government in the form of policies, guidelines and campaigns to ensure accessibility in the Indian socio-political infrastructure are also assessed. The same is followed by the analysis of significant judicial precedents of the Supreme Court and High Courts on different aspects of the right to accessibility, to demonstrate how the courts have spearheaded various structural enhancements in the accessibility regime in India. The paper is concluded by drawing attention to the need for greater synchronicity in the adjudication and implementation of the principle of accessibility.
Microstructure and Microhardness Evolution of Mg–8Al–1Zn Magnesium Alloy Processed by Differential Speed Rolling at Elevated Temperatures
Authors: Alsubaie Saad A. , Al-Zubaydi Ahmed S. J. , Hussein Emad A. , Alawadhi Meshal Y.
Published: August 2024

Mg–8Al–1Zn magnesium alloy was successfully processed using deferential speed rolling (DSR) at temperatures of 400 and 450 °C for thickness reduction of 30, 50, and 70% with no significant grain growth and dynamic recrystallization. Using optical microscopy (OM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM), the rolled microstructures were examined. Although the results indicate a slight reduction in grain size from the initial condition, the DSR processing of alloy at an elevated temperature was associated with a significant number of twins and a distribution of the fine particles of the second phase. The strength in terms of microhardness measurements and strain hardening in terms of shear punch testing was significantly improved in the rolled microstructure at room temperature. The existence of twins and widely distributed second-phase fine particles at twin boundaries reflected positively on the extent of the elongations in terms of shear displacements when microstructures were tested at elevated temperatures in the shear punch testing.
Impact of preS1 Evaluation in the Management of Chronic Hepatitis B Virus Infection
Authors: Hayashi Yuka , Tajiri Kazuto , Ozawa Tatsuhiko , Angata Kiyohiko , Sato Takashi , Togayachi Akira , Nagashima Izuru , Shimizu Hiroki , Murayama Aiko , Muraishi Nozomu , Narimatsu Hisashi , Yasuda Ichiro
Published: August 2024

Background and Objectives: The measurement of hepatitis B surface antigen (HBsAg) is essential for managing chronic hepatitis B virus infection (CHB). HBsAg consists of three different surface envelope proteins: large, middle, and small HB surface proteins. However, in clinical practice, it is not common to evaluate each of these HB surface proteins separately. Materials and Methods: In this study, we investigated preS1 expression using seven monoclonal antibodies (mAbs) in 68 CHB patients, as well as examining their antigenicity. Results: Although the seven mAbs had been derived from genotype (Gt) C, they could recognize preS1 with Gts A to D. The epitopes were concentrated within the aa33-47 region of preS1, and their antigenicity was significantly reduced by an aa45F substitution. We found that preS1 expression remained consistent regardless of HBsAg levels and different Gts in CHB patients, in contrast to what was observed in SHBs. Conclusions: These results suggest that the antigenic epitope is preserved among different Gts and that the expression pattern of preS1 is altered during CHB, highlighting its vital role in the HBV infection cycle. Our present results suggest preS1 is a promising therapeutic target in CHB.
Role of Systemic Immune Inflammation Index, Systemic Immune Response Index, Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Predicting Peritoneal Culture Positivity and Prognosis in Cases of Spontaneous Bacterial Peritonitis Admitted to the Emergency Department
Authors: Efgan Mehmet Göktuğ , Acar Hüseyin , Kanter Efe , Kırık Süleyman , Duman Şahan Tutku
Published: August 2024

Background and Objectives: Spontaneous bacterial peritonitis (SBP) is a life-threatening disease that requires early diagnosis and treatment. It is known that a positive culture result for SBP, which is a common reason for admission to the emergency department, is related to the severity and prognosis of the disease. However, as it is not possible to determine the culture result in the early stage of the disease, different methods are required to predict prognosis in the emergency department. This study was conducted to evaluate the success of the SII, SIRI, NLR and PLR in predicting culture results, intensive care needs and mortality in patients with SBP admitted to the emergency department. Materials and Methods: This study was a retrospective, observational study. Patients with SBP who applied to the emergency department were included in this study. Pregnant women, patients with a malignancy, patients with another infection and patients with liver failure were excluded from this study. Data were analyzed in terms of culture results, the need for intensive care and mortality development. Analyses were performed using SPSS version 26. Results are presented with a 95% confidence interval. A p value less than 0.05 was considered statistically significant. Participant data were analyzed using the independent samples t-test or the Mann–Whitney U test based on normality, and ROC analyses were conducted to assess test accuracies and determine cut-off values. Results: A total of 275 patients were included in this study. Although the culture results of 183 patients were positive, 92 were negative. The SII, NLR and PLR were found to be significantly higher in culture-positive patients (p < 0.001, p = 0.013 and p = 0.002, respectively). The SII and NLR were found to be significantly higher in patients with high mortality (p < 0.001 and p = 0.017, respectively). Conclusions: This study showed that the SII, NLR and PLR may be useful in predicting culture positivity and prognosis in SBP patients in the emergency department.
Investigation on the Bending Properties and Geometric Defects of Steel/Polymer/Steel Sheets—Three-Point and Hat-Shaped Bending
Authors: Maleki Payam , Shahzamanian Mohammadmehdi , Basirun Wan Jefferey , Wu Peidong , Akbarzadeh Abbas
Published: August 2024

Steel/polymer/steel laminates, also known as laminated steels, are composite materials consisting of bonding layers of steel and polymer. The polymer layer acts as a bonding agent between the steel layers, imparting additional properties such as low density, impact resistance, and thermal insulation, while the steel layers provide strength and formability. These laminated steels have found increasing applications in automotive, aerospace, and construction industries to reduce weight and improve fuel efficiency. The bending behavior of this laminates is more complex compared to that of a single layer of metallic sheets. This complexity arises from significant differences in mechanical properties, as well as the thickness ratio between the skin and the core. The flexural properties and behavior of different St14/TPU/St14 laminate sheets that were fabricated using the direct roll bonding (DRB) process were investigated through three-point and hat-shaped bending tests. The direct roll bonding process involves the bonding of steel and semi-melt polymer sheets under the pressure of rollers, ensuring a cohesive and durable composite material. The microscopic analysis of the cross-section of the SPS laminates after the bending processes shows the absence of delamination or slippage between the layers, which indicates the correct selection of materials and the bonding method. The results showed that the springback of three-layer laminates has an inverse relationship with the work-hardening exponent, yield strength, and yield point elongation value, while possessing a direct relationship with normal anisotropy and elastic modulus. Furthermore, the flexural strength and flexural modulus decrease with the increase in the volume fraction of the polymeric core, while the flexural rigidity increases. The findings indicate the DRB technique as a promising method for manufacturing a lightweight metal–polymer laminate with a high formability performance.
Alterations in Vagal Tone Are Associated with Changes in the Gut Microbiota of Adults with Anxiety and Depression Symptoms: Analysis of Fecal Metabolite Profiles
Authors: Pasqualette Laura , Fidalgo Tatiana Kelly da Silva , Freitas-Fernandes Liana Bastos , Souza Gabriela Guerra Leal , Imbiriba Luís Aureliano , Lobo Leandro Araujo , Volchan Eliane , Domingues Regina Maria Cavalcanti Pilotto , Valente Ana Paula , Miranda Karla Rodrigues
Published: August 2024

Accumulating evidence suggests that interactions between the brain and gut microbiota significantly impact brain function and mental health. In the present study, we aimed to investigate whether young, healthy adults without psychiatric diagnoses exhibit differences in metabolic stool and microbiota profiles based on depression/anxiety scores and heart rate variability (HRV) parameters. Untargeted nuclear magnetic resonance-based metabolomics was used to identify fecal metabolic profiles. Results were subjected to multivariate analysis through principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), and the metabolites were identified through VIP score. Metabolites separating asymptomatic and symptomatic groups were acetate, valine, and glutamate, followed by sugar regions, glutamine, acetone, valerate, and acetoacetate. The main metabolites identified in high vagal tone (HVT) and low vagal tone (LVT) groups were acetate, valerate, and glutamate, followed by propionate and butyrate. In addition to the metabolites identified by the PLS-DA test, significant differences in aspartate, sarcosine, malate, and methionine were observed between the groups. Levels of acetoacetate were higher in both symptomatic and LVT groups. Valerate levels were significantly increased in the symptomatic group, while isovalerate, propionate, glutamate, and acetone levels were significantly increased in the LVT group. Furthermore, distinct abundance between groups was only confirmed for the Firmicutes phylum. Differences between participants with high and low vagal tone suggest that certain metabolites are involved in communication between the vagus nerve and the brain.
Estimation of the Potential Antimony Resource in Southern China with the Geochemical Block Method
Authors: Du Yude , Han Zhixuan , Zhang Bimin , Dong Zhengnan , Wei Xiaocheng , Zhao Haonan , Wang Xiaolong , Zhang Man , Liu Hanliang
Published: August 2024

Antimony (Sb) is widely utilized in modern industries and classified as a critical mineral worldwide. China possesses the most abundant Sb mineral resources globally, with over 70% of proven reserves concentrated in southern China. However, due to excessive exploitation, the lifespan of Sb reserves is less than ten years. Therefore, the knowledge of Sb needs to be urgently strengthened. Here, the effectiveness of the geochemical block method to delineate the prospective areas of Sb deposits and determine the potential resource of Sb was studied, with geochemical data covering 2.3 million km2 across southern China. The statistical results showed that the median concentration of Sb in stream sediments (1.05 ppm) in southern China was 1.5 times that of whole China, indicating a significantly elevated background level of Sb in southern China. By setting the threshold value at 2.98 ppm, a total of nine distinct geochemical blocks were delineated. Remarkably, 85% and 76% of the large and medium Sb deposits were located within these geochemical blocks, respectively. Taking the block containing the Xikuangshan giant Sb deposit in Hunan Province as the model, the metallogenic coefficient of Sb is calculated to be 0.32%. The total potential Sb resources in southern China within a depth of 1000 m are estimated to be 21.939 million tons, which are primarily concentrated in the provinces of Hunan, Guangxi, Yunnan, and Guizhou. When the threshold value is set at 4.19 ppm, the predicted potential resources of Sb are 21.45 million tons in twelve blocks, which closely approximate 21.939 million tons. The estimated Sb resource in this study significantly surpasses the proven reserves. The periphery and deep areas of known Sb deposits still hold promising prospects for exploration. This study highlighted the effectiveness of employing the geochemical block method to estimate the potential resources of Sb and determined the ore-prospecting direction of Sb deposits. However, it is important to acknowledge and address the overestimation of predicted resources resulting from the high geological background.
Adding Hyponatremia to the “Rule-of-6” Prediction Tool Improves Performance in Identifying Hospitalised Patients with COVID-19 at Risk of Adverse Clinical Outcomes
Authors: Sim Meng Ying , Ngiam Jinghao Nicholas , Koh Matthew Chung Yi , Goh Wilson , Chhabra Srishti , Chew Nicholas W. S. , Chai Louis Yi Ann , Tambyah Paul Anantharajah , Sia Ching-Hui
Published: August 2024

The ‘rule-of-6’ prediction tool was shown to be able to identify COVID-19 patients at risk of adverse outcomes. During the pandemic, we frequently observed hyponatremia at presentation. We sought to evaluate if adding hyponatremia at presentation could improve the ‘rule-of-6’ prediction tool. We retrospectively analysed 1781 consecutive patients admitted to a single tertiary academic institution in Singapore with COVID-19 infection from February 2020 to October 2021. A total of 161 (9.0%) patients had hyponatremia. These patients were significantly older, with more co-morbidities and more likely to be admitted during the Delta wave (2021). They were more likely to have radiographic evidence of pneumonia (46.0% versus 13.0%, p < 0.001) and more adverse outcomes (25.5% vs. 4.1%, p < 0.001). Hyponatremia remained independently associated with adverse outcomes after adjusting for age, lack of medical co-morbidities, vaccination status, year of admission, CRP, LDH, and ferritin. The optimised cut-off for serum sodium in predicting adverse outcomes was approximately <135 mmol/L as determined by the Youden index. Although derived in early 2020, the ‘rule-of-6’ prediction tool continued to perform well in our later cohort (AUC: 0.72, 95%CI: 0.66–0.78). Adding hyponatremia to the ‘rule-of-6’ improved its performance (AUC: 0.76, 95%CI: 0.71–0.82). Patients with hyponatremia at presentation for COVID-19 had poorer outcomes even as new variants emerged.
Plasma Dynamics and Electron Transport in a Hall-Thruster-Representative Configuration with Various Propellants: II—Effects of the Magnetic Field Topology
Authors: Reza Maryam , Faraji Farbod , Knoll Aaron
Published: August 2024

We investigate the effects of the magnetostatic (B) field topology on the plasma behavior in a 2D collisionless simulation setup that represents an axial–azimuthal cross-section of a Hall thruster. The influence of the B-field topology is assessed in terms of two principal design properties of the field in a typical Hall thruster, i.e., the field’s peak intensity along the axial direction, and the field’s axial distribution. The effects of the field’s intensity are investigated for three propellants—xenon, krypton, and argon. Whereas, the effects of the axial profile of the magnetic field are studied only for the xenon propellant as an example. We primarily aim to understand how the changes in the B-field topology affect the spectra of the resolved instabilities as well as the electrons’ transport characteristics and the contributions of various momentum terms to transport. The numerical observations on the instabilities’ characteristics are compared against the relevant existing theories to determine the extent to which the simulated and the theoretically predicted characteristics are consistent across the studied parameter space. It was, most notably, found that modes related to ion acoustic instability are dominantly present across the simulation cases. The ion transit time instability additionally develops at the highest B-field intensities as a long-wavelength structure. The main influence of the axial profile of the B field on the plasma discharge was observed to be in terms of the electrons’ transport characteristics. Where possible, the insights from the simulations are discussed with respect to the relevant experimental observations available in the literature.
A Review of Rainfall Estimation in Indonesia: Data Sources, Techniques, and Methods
Authors: Putra Maulana , Rosid Mohammad Syamsu , Handoko Djati
Published: August 2024

Rainfall information with high spatial and temporal resolution are essential in various fields. Heavy rainfall in a short period can cause problems and disasters that result in loss of life and damage to property. Conversely, the absence of rain for an extended period can also have negative social and economic impacts. Data accuracy, wide spatial coverage, and high temporal resolution are challenges in obtaining rainfall information in Indonesia. This article presents information on data sources and methods for measuring rainfall and reviews the latest research regarding statistical algorithms and machine learning to estimate rainfall in Indonesia. Rainfall information in Indonesia was obtained from several sources. Firstly, the method of direct rainfall measurement conducted with both manual and automatic rain gauges was reviewed; however, this data source provided minimal results, with uneven spatial density. Secondly, the application of remote sensing estimation using both radar and weather satellites was reviewed. The estimated rainfall results obtained using remote sensing showed more comprehensive spatial coverage and higher temporal resolution. Finally, we reviewed rainfall products obtained from model calculations, using both statistical and machine learning by integrating measurement and remote sensing data. The results of the review demonstrated that rainfall estimation products applied in remote sensing using machine learning models have the potential to produce more accurate spatial and temporal data. However, the validation of rainfall data from direct measurements is required first. This research’s contribution can provide practitioners and researchers in Indonesia and the surrounding region with information on problems, challenges, and recommendations for optimizing rainfall measurement products using appropriate adaptive technology.
Integrated Coastal Zone Management Studies in Turkey in the Context of the United Nations Sustainable Development Goals: An Evaluation Using Bibliometric Analysis
Authors: Satiroğlu Elif
Published: August 2024

In this study, within the framework of four of the UN Sustainable Development Goals, which form the basic principles of coastal sustainability, the targets determined to be related to Turkey were examined in detail, to contribute to the development of an evaluation and measurement system, using the bibliometric analysis method on articles from the Web of Science. Then, we attempted to develop solutions in line with Turkey’s conditions to eliminate the current problems. This study also aimed to contribute to the creation of criteria that could be used as the basis for determining the adequacy and effectiveness of the ICZM through the determination of the goals. In addition, within this study, we assessed Turkey’s current situation regarding integrated coastal zone management and suggested a roadmap for evaluation and future solutions.
The Great Reset as a Realistic Utopia—A Critical Stance from Critical Realism and Complex Systems Theory
Authors: Tortia Ermanno C.
Published: August 2024

The Great Reset (GR) has been presented by the World Economic Forum (WEF) in response to the COVID-19 pandemic in 2022 as a model through which a “stakeholder economy” would achieve “resilient, equitable, and sustainable” social, economic, and ecological reform. The GR agenda includes environmentally sustainable use and more equitable distribution of resources. This article raises the question of whether the Great Reset program should be interpreted as a “realistic utopia” and what its reform potential is. To this end, the GR program is tested against the current state of science and philosophy. The idea of a utopia is analyzed in the light of recent philosophical and scientific approaches, such as critical realism in philosophy, social systems theory in sociology, and complexity theory in science. A comparative conceptual analysis is carried out by introducing the idea of a realistic utopia in Rawls’ theory of justice as fairness. In the final discussion, some doubts are raised about the logical coherence, rigor of scientific theorizing, policy prescriptions, and predictive potential of the Great Reset. It is concluded that utopian projects of radical reform are not realistic due to the supposed long-term repercussions of exogenous shocks or “black swan” events such as the COVID-19 pandemic. Rather, they must offer explanations of the deep structural elements and evolutionary patterns that underlie society and the economy, drawing from these explanations the policy implications, predictions, and prescriptions that can support change.
Are Residents Willing to Pay for Electric Cars? An Evolutionary Game Analysis of Electric Vehicle Promotion in Macao
Authors: Cai Rongjiang , Li Lue , Lei Wenchang
Published: August 2024

This study uses an evolutionary game model to analyze the interplay between Macao residents’ willingness to purchase electric vehicles (EVs) and the government’s promotion strategies. It assesses the effectiveness of incentives like tax exemptions and price reductions. Despite these initiatives, challenges such as high initial costs, limited vehicle range, and long charging times continue to hinder the widespread adoption of EVs in Macao. Government subsidies increase the appeal of EV purchases, but if not managed carefully, they risk creating dependency. Simulation analysis shows that an active purchasing strategy by Macao residents can stabilize the model’s development. However, to achieve wider market penetration and environmental goals, this study highlights the need for the government to align subsidies with market dynamics and for residents to increase their environmental awareness. This study outlines actionable strategies for policy-makers, emphasizing the importance of infrastructure improvements and financial incentives in promoting electric mobility. Policy-makers should focus on expanding the network of charging stations to enhance the convenience and viability of EV usage. Additionally, implementing targeted financial incentives, such as subsidies or tax breaks, can lower the cost barrier for potential EV buyers, thereby increasing the attractiveness and adoption of electric vehicles.