bluuebunny/crossref_metadata_2025 huggingface dataset:
Adequate Food and Nutrition in School: Acceptability and Consumption by Brazilian Students
Authors: Henriques Patricia , Alvarenga Camile Robady Torres de , Menezes Marina Messas Siqueira , Ferreira Daniele Mendonça , Burlandy Luciene , Soares Beatriz Duarte
Published: January 2025

Objective: This study aimed to evaluate the acceptability of a specific menu preparation, based on minimally processed foods, and the factors associated with the consumption of school meals by students in Brazilian public schools. Methods: A hedonic scale was employed to assess the acceptability of a milk preparation with 100% cocoa and sugar. A structured questionnaire was used to evaluate school food consumption, addressing consumption frequency, dietary habits, environmental conditions, and consumption of competing foods. A binomial logistic regression model was conducted to verify the association between individual variables and conditions of meal supply and consumption. Data analyses were performed using the Jamovi 2022 software. Results: A total of 1,080 students participated, with 630 taking part in the acceptability test, and 450 completing the consumption questionnaire. The study highlighted acceptance below the minimum PNAE standards (79.68%) for the tested preparation, indicating a need for further investigation into student preferences. Pleasant taste was the most frequently cited reason (53.2%) for consumption. Disliking the served lunch increased the likelihood of not consuming school meals by 2.73% (p=0.03). Bringing snacks from home showed no significant impact on consumption (p=0.677). Using inadequate cutlery increased the likelihood of not consuming school meals by 6.44% (p=0.009). Conclusion: The study underscored the low acceptance of milk prepared with 100% cocoa and sugar, along with irregular school meal consumption, emphasizing the need for strategies to align students' tastes preferences with healthier menus options. While PNAE ensures nutrient-rich meals, improving flavor, variety, and dining conditions, alongside permanent food and nutrition education, is essential to enhance adherence and support students’ health. Although snacks do not affect the consumption of school meals, controlling snack intake is important from a health perspective.
Correlation Between Co-Design and Psychological Needs Satisfaction Based on fNIRs Hyperscanning
Authors: Li Yan , Chen Junxian , Song Wu
Published: January 2025

With the increasing attention paid to user oriented design and services, the term Co-design, a form of user participatory design, is increasingly mentioned. Previous studies have shown that Co-design could better satisfy user needs in process and results, but there are few studies that have been empirically validated through neuroscience methods. Therefore, this study used fNIRS (functional near-infrared spectroscopy) to measure the brain blood oxygen data (HbO2 & Hb) of both "designer" and "user" participants from design and non-design majors during Traditional and Co-design tasks. The IBS (inter-brain synchronization) between participants were calculated using wavelet coherence packet in Matlab. Research has found Significant activation of DLPFC (dorsolateral prefrontal cortex) and BROCA (pas triangularis Broca's area) was observed in both tasks, with more significant activation observed in Co-design tasks, and IBS activation was significantly positively correlated with needs satisfaction rate. The results showed that Co-design could better activate DLPFC and BROCA brain regions compared to Traditional design, which further supports previous research and expands the possibility of collaborative task paradigms. The increase in Co-design IBS compared to Traditional design also represents better collaborative performance, and could provide empirical evidence for participatory design based on neuroimaging.
Human Papillomavirus and Cervical Cancer Screening
Authors: Pérez-Gracia María Teresa , Tarín-Pelló Antonio , Fernández-Álvarez Sara , Más-Comes Clara , Suay-García Beatriz
Published: January 2025

Human papillomavirus (HPV) is responsible for the most common sexually transmitted infection worldwide. Cervical cancer (CC) is a severe disease that still has a high mortality rate in many countries. Persistent infection by the human papillomavirus is the necessary cause of premalignant lesions, which are precursors of CC. Screening with cytology or Pap smear have been successful in the last few years, but scientific evidence suggests that these techniques should be replaced with HPV DNA detection as the initial test when screening.  There are several commercial techniques approved by the FDA for the detection of high oncological risk HPV genotypes, which have been evaluated for the population screening of 30-65-year-old women. The aim of this article is to review some virologic aspects of HPV and its relationship with cervical cancer screening. Consequently, we suggest that a new algorithm based on individualized detection of genotypes 16 and 18 should be implemented in countries where there is no population-based screening.
Translation Can Distort the Linguistic Parameters of Source Texts Written in Inflected Language. Case Study: Multidimensional Mathematical Analysis of “The Betrothed”, a Translation in English of “I Promessi Sposi” by A. Manzoni
Authors: Matricciani Emilio
Published: January 2025

We compare, mathematically, the text of a famous Italian novel, I promessi sposi written by Alessandro Manzoni (source text), to its most recent English translation, The Betrothed by Michael F. Moore (target text). The mathematical theory applied does not measure the efficacy and beauty of texts, but only their mathematical underlying structure and similarity. The translation theory adopted by the translator is the “domestication” of the source text. The translator justified the almost total replacement of semicolons with periods because English is not as economical in its use of subject pronouns as Italian. Question and exclamation marks, and commas too, were largely modified. These modifications produce several consequences. The short-term memory buffers required to the reader are diverse in Italian and in English. The number of sentence patterns allowed in Italian is about two orders of magnitude greater than in English. The geometrical representation of texts and the related probability of error indicates the two texts are practically uncorrelated. All linguistic channels are very noisy, with very poor signal-to-noise ratio, except the channel related to characters and words. Readability indices are also diverse. In conclusion, a blind comparison of the linguistic parameters of the two texts would unlikely indicate they refer to the same novel.
Meat consumption and racial/ethnic disparities in population-based study in the city Campinas, Brazil
Authors: Agda dos Santos Samara , Steluti Josiane , Simonian Rodrigues Valente Ghedini Natália , Martins Álvares Domene Semíramis
Published: January 2025

The aim of the present study was to investigate meat consumption among adults residing in a city in the countryside of São Paulo, Campinas, according to ethnicity/skin color in two periods: 2008/2009 and 2014/2015, given the scarce literature on the subject. Thus, we sought to evaluate the association between race/color and consumption of meat, a food of great cultural value, based on the hypothesis that this demographic marker is relevant to explain food choices. A cross-sectional population-based study evaluating participants from the Health Survey of the City of Campinas (ISACAMP) was conducted in 2008/2009 and 2014/2015, with 2,354 and 1,606 individuals respectively, aged 20y or older. Food consumption data were collected using the 24-hour food recall method and meats were classified according to animal origin and type of processing. Linear regression models were run to assess the association between meat consumption and sociodemographic variables with a significance level of 5%. Lower total consumption of meat, red meat, beef and fish was found among individuals with self-declared black skin color compared to those with self-declared white skin color. Red meat consumption varied from 109.4g to 157.9g in 2008/2009 and from 102.1g to 125.1g in 2014/2015 between the groups, remaining above the recommendation in both periods. The World Cancer Research Fund recommends consuming between 50 and 71.4 g/day of red meat; thus, these findings reinforce the importance of studies that investigate the impact of ethnicity on food consumption, since racial disparities may be in the origin of the insufficient or excessive consumption of certain types of meat, and understanding the factors associated with the consumption of types of meat is relevant for the adoption of health actions aimed at adequate food intake.
Hubungan Durasi Pemakaian Earphone dengan Kejadian Serumen Obturans
Authors: Listyowati Kanina , Dewi Pratiwi  , Novi Primadewi
Published: January 2025

Pendahuluan: Serumen obturans merupakan keluhan telinga yang sering terjadi di Indonesia dengan prevalensi sebesar 18,8%. Penggunaan earphone berlebihan merupakan salah satu faktor risiko serumen obturans. Saat ini, penggunaan earphone di kalangan mahasiswa meningkat, terutama karena kebutuhan hiburan dan pembelajaran daring. Penelitian ini bertujuan untuk mengetahui hubungan durasi pemakaian earphone dengan kejadian serumen obturans.
Metode: Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross-sectional untuk menganalisis hubungan antara durasi penggunaan earphone dengan kejadian serumen obturans. Teknik pengambilan sampel yang digunakan adalah purposive sampling dengan randomisasi, dan pengumpulan data dilakukan melalui kuesioner serta pemeriksaan otoskop. Analisis data menggunakan uji chi-square untuk mengukur hubungan antara kedua variabel.
Hasil: Penelitian dilaksanakan di Fakultas Kedokteran Universitas Sebelas Maret Surakarta pada bulan Juli hingga September 2024. Subjek penelitian adalah mahasiswa kedokteran angkatan 2021 yang memenuhi kriteria inklusi dan eksklusi, dengan jumlah sampel sebesar 71. Terdapat 20 sampel yang memiliki serumen obturans dan 51 sampel yang tidak memiliki serumen obturans. Hasil uji chi-square menunjukkan durasi penggunaan earphone berhubungan signifikan hubungan sedang dengan kejadian serumen obturans (p = 0,002; C = 0,346).
Kesimpulan: Terdapat hubungan signifikan antara durasi penggunaan earphone dan kejadian serumen obturans pada mahasiswa kedokteran Universitas Sebelas Maret angkatan 2021, dengan kekuatan hubungan sedang.
ANALYSIS OF THE UTILIZATION OF TRADITIONAL HOPONG DANCE IN TEACHING RHYTHMIC ACTIVITIES IN SCHOOLS
Authors: Arif Yudabbirul
Published: January 2025

This study aims to analyze the utilization of the traditional Hopong dance as a medium for teaching rhythmic activities to seventh-grade students at SMP Negeri 6 Kupang Barat. Originating from the Helong tribe in East Nusa Tenggara, the Hopong dance carries profound cultural and philosophical values. Its movements combine elements of aesthetics, rhythm, and expression, which are relevant to the development of rhythmic activities in physical education. This research employs a naturalistic qualitative descriptive method, with data collected through observation, interviews, and documentation. The research subjects include physical education teachers and seventh-grade students. The data were analyzed to identify the role of basic Hopong dance movements in supporting students' physical abilities, such as muscle strength, balance, flexibility, and agility, as well as their impact on understanding local culture. The results show that the use of the Hopong dance as a teaching medium for rhythmic activities significantly benefits students, both in physical aspects and in their appreciation of regional culture. Students demonstrated high enthusiasm during the learning process, creating a fun and supportive atmosphere for creativity. This study recommends that the Hopong dance be more widely used as a teaching medium to preserve cultural heritage while enhancing students' skills
THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON INCREASING ENDURANCE IN KARATE ATHLETES IN BONANG DEMAK
Authors: Wijianto
Published: January 2025

Abstract Karate is a martial art that focuses on empty-handed combat, involving techniques like punches, kicks, and blocks. Endurance refers to the body's ability to supply oxygen to muscles during prolonged activity. High-Intensity Interval Training (HIIT) consists of short, intense exercise cycles (85%-95% of HR max) followed by rest periods of light activity. This study aims to examine the effect of HIIT on improving endurance in karate athletes in Bonang, Demak. Using a quasi-experimental method, the research applied a Pretest-Posttest with Control Group design to assess the impact on two groups. The study revealed that 65% of participants were male, and 70% were aged 15-19 years. A Non-Parametric Test was used to assess the effect of the intervention. The results showed a significant improvement in endurance before and after the intervention. After a 4-week program, the research demonstrated that HIIT positively influences endurance in karate athletes in Bonang, Demak.
Improving Brain and Heart Performance as a Basis for Islamic Household Accounting Practices
Authors: Septyan Krisno , Nugraheni Ranti , Setyawan Andy , Tri Wahyudi Chandra
Published: January 2025

This community service program aimed to raise awareness among housewives about their roles in household management, with a particular focus on financial responsibilities. Utilizing a lecture-based methodology that integrates humanist and theocentric perspectives, the program emphasized that women should not bear sole responsibility for managing household finances. The initiative also incorporated brain exercises to enhance memory, serving as a tool for recording and retaining important household information. These exercises were designed to improve cognitive function while also promoting emotional well- being, highlighting that true peace (sakinah) in the home stems not from material wealth but from spiritual fulfillment and trust in God. Additionally, the program addressed the growing concerns surrounding online financial risks, such as digital loans and online gambling, educating participants on how these threats could deplete household assets. Ultimately, the program aimed to equip housewives with the knowledge and tools to manage household finances effectively, while fostering a balanced approach that integrates cognitive, emotional, and spiritual health, thus contributing to a harmonious and financially secure family life.
Aplikasi Tandan Kosong Kelapa Sawit dan Limbah Cair Pabrik Kelapa Sawit pada Tanaman Kelapa Sawit Menghasilkan (Elaeis Guineensis Jacq)
Authors: Priambodo Okta Nindita , Erdiansyah Naufal Al-Fattah
Published: January 2025

Oil palm is one of the important plantation commodities in Indonesia, with a plantation area reaching 14.33 million hectares and continuing to grow. This growth has led to an increase in the number of oil palm processing factories, which produce solid waste of Empty Fruit Bunches (EFB) and liquid waste of Palm Oil Mill Effluent (POME). If not processed properly, this waste can pollute the environment. However, this waste can be used as organic fertilizer that is rich in nutrients, reducing dependence on inorganic fertilizers, and saving costs. At the Rama-Rama Oil Palm Plantation, this waste is used as a soil conditioner and source of nutrients, with the hope of increasing oil palm productivity. This study aims to determine the effect of EFB and POME applications on oil palm productivity by comparing productivity between land applied with EFB and POME using the Independent T Test method at a real level of 5%. The results of observations show that POME and EFB applications affect the production of fresh oil palm fruit bunches, the number of fresh oil palm bunches, and the weight of oil palm bunches. POME application has a greater impact on the production of fresh oil palm fruit bunches, the number of fresh oil palm bunches, and the weight of oil palm bunches compared to EFB application and without POME and EFB application. The average production of fruit bunches in the EFB and POME blocks each month is above its production potential according to the land suitability level of class S2.
Optimasi Penggunaan Kembali Limbah Karbon Aktif Industri Vetsin Sebagai Biochar Menggunakan Taguchi Orthogonal Array L4
Authors: Setiyo Irnanto Anggra , Handoko Fourry , Laksmana Dimas Indra
Published: January 2025

PT XY is a company producing vetsin in the food industry. The company makes extensive use of material resources for its industrial development, which has an impact on the environment. Waste-activated carbon is the result of the color absorption process of the solution. The problem is that the waste generated causes pollution to the company's environment and cannot be stored for long. The average carbon waste generated from January to December 2023 is 86.40 tonnes. Therefore, it is necessary to reuse activated carbon waste into biochar or carbon fertilizer. Processing strategy by conducting experiments using the Taguchi method. Problem identification with an approach that refers to the Responsible Waste Management Hierarchy, and limits the implementation of experiments to the principle of reuse. The Taguchi Orthogonal Array L4 method was chosen for the experimental design because it is more cost-effective than other DOEs and the signal noise is predictable. This research was conducted through experimental methods to know the effect of biochar planting media from activated carbon waste on the growth of kale plants (gr) and get optimal composition variations. As a result, an optimization design was obtained with wet carbon waste material, 25% biochar concentration, and bright light conditions, with an n-gain value of 4.49 resulting in a high improvement category. Comparison of biochar quality with Charcoal Powder from Workplant Store by SNI 06-3730-1995 standard. In biochar products from activated carbon waste, there is a glutamate content of 0.345 g/dL which is a good amino acid for plant growth.
Muhammadiyah Boarding School (MBS) As A Pioneer Effort For An Educational Institution For Ulama Cadres
Authors: Habibi Ibnu , Tobroni Tobroni , Supriyatno Triyo , Barizi Ahmad , Al Farisi Salman
Published: January 2025

The aim of this research is to analyze the efforts of the Muhammadiyah Boarding School (MBS) Al Amin Bojonegoro in pioneering the education of ulama cadres, the concept of ulama from the perspective of Islamic boarding schools, and the strategies implemented by Islamic boarding schools in the education of ulama cadres. This research approach uses a descriptive-qualitative method with a case study approach. The techniques used in collecting data were observation, interviews, and documentation. The results of his research concluded: The concept of ulama at PP MBS Al Amin Bojonegoro is to have the characteristics of tafaqquh fiddiin in a more general sense, namely those who are competent in the field of Islamic religion, have memorized the Al-Qur’an and can convey knowledge through lectures and sermons in the community. The efforts made by Islamic boarding schools in pioneering education for ulama cadres are in the following ways: a) Education and training through formal educational institutions (schools/madrasah) which are integrated with religious studies; (b) Strengthening and accelerating memorization of the Al-Qur’an by holding special training programs for tahsin, tamrin and tasmik; (c) Habituation of Santri Activities, for 24 hours the santri activities are arranged in such a way by scheduling clerical activities, for example tahajud prayers, sunnah prayers, and Diniyah lessons; (d) Collaborative curriculum planning and implementation between the Islamic boarding school curriculum and the national curriculum by preserving the tradition of studying the Turats book which is the hallmark of Islamic boarding school intellectuality.
Integrated Boarding Systems University: An Effective Formula for Creating a Good Man
Authors: Inayah Firda
Published: January 2025

This article aims to explain the educational structure at UNIDA Gontor as a Boarding system University. This system is considered both appropriate and effective as a solution to the problem of the Westernization of Islamic education and as an effort to realize the Islamization of knowledge. This study employs a qualitative research design. To address the subject matter, the researcher uses a philosophical approach and an analytical descriptive method. The study concludes that the integration of the university and pesantren educational systems expands the essence and scope of the curriculum. The essence of the curriculum encompasses not only academic education with a range of courses but also non-academic education shaped by the pesantren system, designed beyond classroom activities. Furthermore, the integration of these two curricula in practice involves various activities, including formal, informal, and non-formal education, all of which are structured to instill an Islamic worldview. This holistic system is envisioned as a means of revivalism and the reformulation of a unique new system for the resurgence of Islamic universities, serving as a medium for the emergence of the insān al-kāmil (the complete human), in alignment with the true objectives of Islamic education.
Prevalencia de agenesia de terceros molares en una subpoblación peruana. Un estudio en radiografías panorámicas
Authors:   , Vergara Salas Ana Lucia
Published: January 2025

Objetivo: Determinar la prevalencia de agenesia de terceras molares mediante radiografías panorámicas en una subpoblación peruana. Metodología: Este estudio observacional fue aplicado en una muestra de 1200 radiografías panorámicas digitales de individuos de 17 a 22 años (674 mujeres y 526 hombres) de un centro radiológico privado de Lima obtenidas en 2021. Una observadora calibrada identificó la presencia y localización de agenesias de terceros molares (3M) según arcada, lado, cuadrante y cantidad. Otros datos incluyeron presencia de dientes supernumerarios, agenesias y fusión. Resultados: La agenesia de 3M tuvo una prevalencia de 19,6% y fue más frecuente en la arcada inferior, de ambos lados, en el cuadrante IV y en una cantidad de uno por individuo. La prevalencia no se encontró asociada a la arcada (p=0,591), lado (p=0,658), cuadrante (p=0,685), cantidad (p=0,573) y sexo (p=0,378). Las agenesias de varones se asociaron al maxilar superior, mientras que en mujeres se asociaron al maxilar inferior (p=0,000). No hubo diferencias de la agenesia entre varones y mujeres según lado (p=0,393), cuadrante (p=0,383) y cantidad (p=0,850). No se hallaron anomalías de fusión y geminación. Los dientes supernumerarios fueron infrecuentes (2,8%) y no se asociaron a la agenesia de 3M (p=0,272). Conclusiones: La prevalencia de agenesia de 3M afectó a la quinta parte de la subpoblación peruana evidenciándose una asociación significativa en relación con el sexo femenino y en ambas arcadas.
Nivel de satisfacción del uso de la teleconsulta versus consulta presencial en pacientes atendidos en servicios de salud mental de hospitales en Lima metropolitana en el 2023
Authors:   , Garro Mendiola Hugo , Quintanilla Gallegos Tatiana Patricia
Published: January 2025

OBJETIVO: Determinar la diferencia entre el nivel de satisfacción en teleconsulta y en consulta presencial en pacientes atendidos en servicios de salud mental en hospitales de Lima Metropolitana. MÉTODOS: Estudio transversal que propone la comparación entre los niveles de satisfacción de los tipos de consulta ambulatoria que asisten los pacientes atendidos en servicios de salud mental de los hospitales referenciales. En el siguiente estudio se propone la exploración del nivel de satisfacción entre consulta presencial y teleconsultas, y su funcionamiento posterior a la pandemia, en este rubro que es la teleconsulta en servicios de salud mental. RESULTADOS: Se evaluaron 188 encuestas sobre satisfacción en consultas presenciales y teleconsultas en servicios de salud mental de hospitales de Lima Metropolitana, centrándose en factores sociodemográficos. La muestra incluyó a 188 participantes de 18 a 80 años. El análisis demostró la predominancia femenina (53.72%), estados civiles y diversas ocupaciones. No se hallaron diferencias significativas en la satisfacción según sexo, edad o estado civil. Sin embargo, la situación laboral mostró una tendencia hacia la significancia (p = 0.19). Los resultados sugieren que el desempleo podría influir ligeramente en la satisfacción. Respecto al lugar de procedencia, no se identificaron diferencias significativas (p = 0.92). En cambio, en telemedicina, la edad mostró una asociación significativa con la satisfacción (p = 0.02), mientras que el sexo, estado civil y lugar de procedencia no la mostraron (p > 0.05). Aunque no se hallaron diferencias significativas según la ocupación (p = 0.87), se observó una tendencia hacia mayor satisfacción entre los empleados. CONCLUSIONES: El estudio no muestra diferencias significativas en la satisfacción entre teleconsultas y consultas presenciales, pero señala una…
Estudio retrospectivo de la frecuencia de caninos con diagnóstico presuntivo de alergia alimentaria en el Sector 10 del distrito de San Borja durante el año 2022
Authors:   , Cisneros Castañeda Pedro Mariano
Published: January 2025

Existe una brecha en el conocimiento sobre la frecuencia específica de alergias alimentarias en caninos, que abarca aspectos como la incidencia por razas, edad, sexo y signos clínicos asociados. Esta falta de datos limita la capacidad de los médicos veterinarios para comprender plenamente la prevalencia del problema y, en consecuencia, para proporcionar tratamientos efectivos. El objetivo de este estudio fue determinar la frecuencia de caninos con diagnóstico presuntivo de alergia alimentaria en el sector 10 del distrito de San Borja, Lima, Perú. Este estudio fue realizado en la Universidad Científica del Sur. Se evaluó la población total de pacientes caninos que acudieron por consulta dermatológica a seis clínicas veterinarias ubicadas en el sector 10 del distrito de San Borja durante el año 2022. Se recopiló la información procedente de las historias clínicas de los pacientes con diagnóstico presuntivo de alergia alimentaria. Se evaluaron los signos clínicos y las características asociadas a los signos individualmente. Los datos fueron analizados en el programa Microsoft Excel 16.58 y resumidos mediante estadísticos descriptivos y gráficas estadísticas. Del total de 962 pacientes que acudieron a los centros veterinarios por problemas dermatológicos, 84 fueron diagnosticados presuntivamente con alergia alimentaria (8.7%). De estos, 41 (48.8%) siguieron un tratamiento con una dieta de exclusión durante 2 a 3 meses aproximadamente como parte del tratamiento y experimentaron una mejoría positiva en su condición, en términos de la eliminación total de los signos clínicos. En los 43 pacientes restantes (51.1%) que fueron diagnosticados presuntivamente con alergia alimentaria, no se obtuvieron datos de la culminación del tratamiento. No se observaron diferencias significativas en la frecuencia de alergia alimentaria en relación con la edad, el sexo y la raza.
Barreras comerciales y su impacto en la comercialización de medicamentos en la línea de Boticas Otifarma Perú - 2022
Authors:   , Ching Guevara Samira Gineth , Huere Guevara Rebeca
Published: January 2025

El objetivo principal del presente estudio fue determinar el impacto existente entre barreras comerciales y el comercio de medicamentos en la línea de boticas Otifarma, Lima, Perú, 2022. Se trató de una investigación no experimental de enfoque cuantitativo, nivel correlacional causal; de tipo aplicada. Su grupo poblacional lo constituyeron 82 especialistas trabajadores de la línea de boticas OTIFARMA. Se procedió utilizar la técnica encuesta y cuestionarios validados por expertos, lográndose recoger información referida a las variables propuestas. Al mismo tiempo los cuestionarios se sometieron al factor Alfa de Cronbach para calcular su confiabilidad de 0,854 y 0,869 respectivamente. Los resultados exteriorizaron una significancia estadística valorada en 0,000 y un índice de correlación de 0,960, expresando correlación muy alta; además de una regresión lineal valorada en 0,867 predice que la variable denominada barreras comerciales impacta en un 75% en la variable comercialización de medicamentos. La conclusión abordada determinó que Las barreras comerciales muestran un impacto en nivel medio, en la medida que se constituyen como medidas restrictivas en los diversos procesos comerciales, implantadas por el estado con la finalidad de evitar intercambios de productos y bienes con otros países.
SYNCHRONIZATION OF GnRH AND PGF2Α ON THE REPRODUCTIVE PERFORMANCE IN ACEH CATTLE
Authors: Melia Juli , Desita Ella , Khalifah Hadid , Justika Wulan , Armansyah Teuku , Hasan Muhammad , Rosmaidar Rosmaidar , Sayuti Arman , Aliza Dwinna , Wahyuni Sri
Published: January 2025

This study aims to determine the effect of administering gonadotropin-releasing hormone (GnRH) accompanied by prostaglandin F2 alpha (PGF2α) on the reproductive performance of female Aceh cattle. In this study, eight female Aceh cattle were used, divided into two groups, group I (K1, n= 3) which received estrus synchronization treatment with PGF2α and group II (K2, n= 5) which received estrus synchronization treatment with PGF2α (25 mg/cow) and gonadotropin-releasing hormone (GnRH, 100 µg/cow). GnRH injection in K2 was performed 48 hours after PGF2α injection. The estrus displays measured included onset, duration, and intensity of estrus. Blood collection for estrogen examination was taken from day 1 to day 5 after PGF2α injection, while progesterone examination was taken on days 7, 14, and 21 after artificial insemination. Ovarian response and pregnancy examinations were performed using transrectal ultrasonography (USG). Data on estrus appearance and steroid concentration were analyzed using the Mann-Whitney U test, and differences in pregnancy percentage were analyzed using the chi-square test. In contrast, the number of follicles, dominant follicle diameter, and corpus luteum were analyzed using a split-plot test. Oestrus intensity, oestrus onset, oestrus duration, pregnancy percentage, estrogen and progesterone concentrations, ovarian response in class II follicles, class III follicles, and CL size in K1 vs K2 showed no significant differences (P0.05).  The effect of time on ovarian response in class III follicles and CL size showed a significant difference (P0.05). In contrast, the interaction between hormone administration and day of treatment on ovarian response in class II follicles, class III follicles, and CL size showed no significant difference (P0.05). Based on the research results, it was concluded that administration of GnRH accompanied by PGF2α tends to increase the reproductive performance of Aceh cattle.
Identification of Colorectal Adenocarcinoma Key Genes to Be Validated as Potential Prognosis Biomarkers
Authors: Mahgoub Elham Omer , Mankar Pooja Prakash , kumar Amit , Naqv Syed Asif , Mittal Bharti
Published: January 2025

Background: Colorectal Adenocarcinoma (COAD). continues to be one of the leading causes of death worldwide. The patient's chance of survival increases with the early prognosis of a malignant tumor.
Methods: Advanced bioinformatics methods were used to gain a thorough understanding of the genetic landscape of colorectal cancer. The transcriptome RNA-seq raw data were obtained from PRJEB24758 in the European Nucleotide Archive (ENA) database. Then, the Sequence Read Archive (SRA) runs a selection to download the sequences database. The transcriptomic RNA released data is analyzed by the bioinformatics tool, which also uses online analytic tools to help visualize the results and identify key genes that may be employed as prognosis biomarkers in the future. The annotation pathways have been determined using David's annotation tools, and cluster analysis in Gsea and the c-bioportal database also showed the significance of these pathways. Two hundred fifty miRNA overlapped with the highest two upregulated and downregulated genes that were subjected to screening. The Venn diagram determined the common genes that the immunogenic genes set and cell type gene signature.
Results: 1,274 genes with substantial differential expression in colorectal cancer were found using stringent approaches such as HISAT2 alignment and DeSeq2 analysis. This study identified 913 upregulated genes of colorectal adenocarcinoma (COAD). The upregulated genes-expressed profile of COAD was studied. The upregulated genes are controlled by 20 pathways expressed in colorectal adenocarcinoma. David's annotation tool was used to prepare diagrams for the KEGG analysis, enriched genes, and many more diagrams. The resulting miRNA overlapped genes interacted significantly with TF to produce key genes. From a different perspective, fifty-seven upregulated common genes were determined using the Venn diagram, and higher mutated genes were selected. Investigating these key genes for targeted therapy in colorectal cancer therapy is crucial, as the study emphasizes.
Conclusion: Thus, the development of novel therapeutic approaches and the identification of key genes of the changed expression of genes implicated in COAD drug resistance are crucial goals for the ongoing advancement of COAD therapy.
Facet-selective electrostatic assembling of 2D MXene onto anisotropic single-crystal metal oxides for enhanced photocatalysis
Authors: Kashiwaya Shun , Myakala Stephen , Nekita Sho , Tsuji Yuta , Niu Yuran , Xianjie Liu , Qin Leiqiang , Kakharov Alexei , Hultman Lars , Dominik Eder , Saito Hikaru , Cherevan Alexey , Rosen Johanna
Published: January 2025

This work demonstrates an electrostatic assembly strategy for the facet-selective deposition of two-dimensional (2D) transition metal carbides (MXenes) onto anisotropic single-crystal semiconducting metal oxides. By precisely controlling the solution pH, we modulated the surface charge of the MXenes and the distinct crystallographic facets of the metal oxides, enabling selective deposition driven by electrostatic attraction. Specifically, negatively charged Mo4/3C MXenes were selectively deposited on the electron-rich (101) surface of TiO2 exposed with {101} and {001} facets at pH 3, the (100) surface of Cu2O, exposed with {100} and {111} facets at pH 11, and the (010) surface of BiVO4, exposed with {010} and {110} facets at pH 1.5. The high degree of facet selectivity was confirmed through a combination of advanced techniques, including electron microscopy, electron spectroscopy, and synchrotron-based spectromicroscopy. This selective interfacial engineering promotes spatially separated charge carrier migration towards distinct facets of the oxides, while Schottky barriers form at the MXenes/oxides interfaces, further enhancing charge separation. The MXenes act as efficient reduction co-catalysts, facilitating the rapid consumption of electrons trapped at the Schottky barriers, thereby enhancing photocatalytic hydrogen evolution.
MR neurography of tibial and common peroneal nerves in patients with Guillain-Barre syndrome and electrophysiological correlation
Authors: Cao Jinfeng , Wang Shanshan , Gong Tao , Zheng Wenjing , Sun Peng , Wang Guangbin
Published: January 2025

Background
The early and accurate evaluation of peripheral nerve injury in Guillain–Barre syndrome (GBS) patients is of great significance for clinical diagnosis and treatment. There has been recent interest in using Diffusion-weighted imaging with background suppression (DWIBS) to evaluate peripheral nerves and corresponding lesions, but has not been applied in GBS patients.
Objective
To explore the value of MR neurography in evaluating tibial nerve (TN) and common peroneal nerve (CPN) in GBS patients.
Methods
36 GBS patients and 36 healthy volunteers were included in this prospective study. The cross-sectional areas (CSA) and signal-to-noise ratio (SNR) values of TN and CPN on T2-weighted images were calculated. Four-grade scoring system was used to score DWIBS images of TN and CPN. The CSA and SNR values, nerve scores on DWIBS were compared. Pearson correlation tests were used to assess the correlation between the CSA and SNR values, nerve scores and electrophysiology parameters of the GBS group.
Results
The interobserver agreement of measurements and nerve scored values was excellent. The mean CSA and SNR values of TN and CPN were significantly larger in patients than healthy controls (P<0.05). There were statistically significant differences in nerve scores between two groups (P < 0.01). The SNR values of TN correlated negatively with motor nerve conduction velocity (MCV) and motor nerve conduction amplitude (P < 0.01). The SNR values of CPN correlated negatively with MCV (P = 0.02). The nerve scores of TN and CPN were all positively correlated with MCV and motor nerve conduction amplitude (P < 0.01).
Conclusions
MR neurography showed larger CSA, higher SNR values of TN and CPN and unclear nerve on DWIBS. The SNR values and nerve scores on DWIBS have correlation with electrophysiological parameters. These findings suggest that MR neurography can be useful to assess the damage of TN and CPN in GBS patients.
Whole-exome sequencing screening for candidate genes and potential pathogenic variants associated with early-onset high myopia in 47 Chinese families
Authors: Rui Xue , Li Huiping , Ma Runqing , Yang Shangying , lian Yuanyuan , Cheng Wanyu , Ma Meijiao , Rong Weining , Sheng Xunlun
Published: January 2025

Early-onset high myopia (eoHM) occurs before school age and is an ideal model for monogenic studies of high myopia due to minimal environmental influence. This study screened for genes and variants associated with eoHM in 47 unrelated Chinese patients with eoHM. Protein-protein interaction (PPI) network analysis was conducted to detect interactions among candidate genes, and protein-protein docking was performed. In 28 patients (28/47, 59.6%), 32 potential pathogenic variants in 22 candidate genes were identified, including 24 novel variants. Among these 28 patients, 64.3% (18/28) carried pathogenic variants in RetNet genes. Of these, 12 patients (42.9%, 12/28) had pathogenic variants in six known genes (TSPAN12, CACNA1F, USH2A, RPGR, COL2A1, and COL11A1), which are responsible for retinal dystrophy and Stickler syndrome associated with eoHM. Additionally, 7 patients (25.0%, 7/28) carried pathogenic variants in seven candidate genes for ocular disease (POLA1, TMEM231, HK1, GSN, COL5A1, CRYBB3, and WDR), which were identified as potentially pathogenic in Chinese eoHM patients for the first time. Phenotype analysis showed that 11 patients presented with only high myopia, 10 patients had inherited retinal diseases (IRDs) with eoHM, and 7 patients had ocular-only Stickler syndrome (Ocular-STL) with eoHM. The initial clinical records of these 17 patients did not show recognizable signs of other primary diseases except for high myopia, and further specific clinical examinations confirmed the diagnosis of IRDs or Stickler syndrome through eoHM. The PPI network analysis identified 87 candidate genes associated with early-onset high myopia (eoHM), grouped into four functional clusters. Thirteen hub genes, including RPGR, COL5A1, CRYAB, and FBN1, were crucial for the pathogenesis of myopia. The network showed strong biological relevance with highly significant enrichment (p-value < 1.0e-16). Our study expands the list of candidate genes associated with eoHM and suggests that eoHM may be the first reason for children to visit an ophthalmology clinic and an important clue for clinicians to detect underlying ocular diseases. These findings highlight the complex interplay of these genes, providing valuable insights into the molecular mechanisms of myopia and potential targets for future therapeutic interventions.
Identification of Key Genes in Colorectal Cancer Associated with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease
Authors: Yang Jingbang , Deng Yizhang , Chen Na , Lin Dagui , Zhao Enen , Zhang Linjie , Li Liren
Published: January 2025

Inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) are both gastrointestinal inflammatory diseases that exhibit a significant correlation with an elevated incidence of colorectal cancer (CRC). However, the mechanisms that contribute to the increased risk of CRC in patients suffering from IBD and PSC remain poorly understood. In this study, two distinct modules were identified within the PSC and IBD cohorts by using WGCNA. Following the intersection of 243 genes from these modules, 21 prognosis-related factors were screened through univariate Cox regression analysis. An unsupervised consensus clustering algorithm was then applied, leading to the identification of two subtypes. Survival analysis revealed that cluster 2 exhibited a poorer prognosis. Subsequently, LASSO and multivariate Cox regression analyses were conducted to identify 5 critical genes from the prognosis-related factors, thereby establishing a prognostic risk model. Higher risk score correlated with a poorer prognosis. A nomogram was constructed based on the risk model and clinical factors. Its prognostic prediction ability was validated through calibration curves and decision curve analysis (DCA), demonstrating good accuracy. Survival analysis indicated that FLOT1 was strongly correlated with poor prognosis in both cohorts, and its role in promoting tumor growth and invasion in CRC was verified in vitro.
Analysis of high-risk factors and prognosis of early relapse in 104 patients with natural killer/T-cell lymphoma: a single-center retrospective study
Authors: Zhang Mengjuan , Li Xin , Li Xinyue , Shi Chunzhen , Wu Xiaolong , Zhang MingZhi
Published: January 2025

Objective:To investigate the risk factors for early recurrence in natural killer/T-cell lymphoma(NKTCL) patients following anti-tumor therapy, and to assess the effects of various treatment approaches on the prognosis of NKTCL patients.
Methods: Retrospective analysis was performed on 104 newly treated NKTCL patients. The patients were categorized into two groups:POD24 and non-POD24, based on whether the disease progressed after the first 24 months of treatment or not.
Results: The POD24 group's 3-year and 5-year overall survival(OS) rates were 47.63% and 30.99%, respectively, while the non-POD24 group's rates were 63.99% and 44.58%. Elevated lactate dehydrogenase(LDH)(P=0.036), PET-CT SuvMax≥21.0(P=0.021) and failure to achieve complete response(CR) at the end of treatment(P=0.017) were associated with the early recurrence of NKTCL. The DDGP group had higher 5-year OS(P=0.048) and PFS(P=0.044) rates than the other groups(SMILE, P-Gemox, VIDP, DICE, etc.).The CR rate of radiotherapy plus chemotherapy was significantly higher than that of chemotherapy alone(P < 0.001).
Conclusion: POD24 can serve as a prognostic indicator for identifying the survival of NKTCL patients, aiding in the formulation of optimal treatment strategies in clinical practice. Clinically, high-risk early relapse patients can be identified early through general clinical characteristics, allowing for intervention to improve disease prognosis. The DDGP regimen can demonstrate better long-term efficacy in newly treated NKTCL patients, while the combination of radiotherapy and chemotherapy can provide better short-term efficacy for localized NKTCL patients.
Implementation of School Improvement Program in Secondary Schools in Assosa zone
Authors: Mesfin Shimelis
Published: January 2025

Purpose: The purpose of this study was to assess the implementation of school improvement program (SIP) in secondary schools of Assosa zone.
Methods: Descriptive survey design was employed. The size of the population was 316 which consisted of 302 teachers and 14 school principals. Of these, 177 respondents were taken into the sample using stratified random sampling technique. Close ended questionnaire and interview were used to collect the data. Descriptive and inferential statistical analysis techniques were used to analyze the data collected through the questionnaire.
Results: The result of one sample t-test showed that teachers and school principals had low perception on the awareness, planning and implementation of SIP. The result of independent sample t-test revealed that statistically significant mean differences were not found between teachers and school principals on awareness, planning, and implementation. The result of one way ANOVA indicated that there was no significant difference among respondents on awareness of SIP due to their work experience, while had different perception on the planning, and implementation of SIP. SIP was poorly implemented due to lack of awareness, resources, skilled manpower, collaboration, smooth relationships; follow up on SIP and absence of self-evaluation.
Conclusion: Based on the finding of this study, it is concluded that SIP is poorly implemented due to personal and institutional factors.
Prevalence and Risk Factors associated with Malaria infection in Children under five years in Northern Uganda.
Authors: Kula Jaspher , Opoke Robert
Published: January 2025

Background: Malaria still remains the leading cause of morbidity and mortality among children in sub-Saharan Africa with over 95% of children in Uganda particularly still suffering from it. About US$9 is annually lost in malaria treatment which is estimated at 3% of the family annual income. Malaria remains a prominent public health burden despite several attempts in recent years to control its spread. This study ascertained the prevalence and associated risk factors of malaria infection in children below 5 years old.
Methods: A cross-sectional study was done in two randomly selected villages in Otangocinge parish, Arwotcek sub county on children under five years screened for malaria from Arwotcek Health Centre II from December 2019 to October 2020 to ascertain the risk factors associated with malaria infection and their mothers or caretakers were interviewed to ascertain the risk factors of malaria infection in Amolatar District. Prevalence of malaria in children under five years old was calculated as a proportion of the malaria positive cases versus negative cases at 95% CI (confidence interval). Bivariate analyses were conducted by determining the associations between prevalence of malaria and its associated risk factors using Chi-square (χ2) test followed by binary logistic regression taking into consideration p-values < 0.05 as significant factors using the SPSS software version 20.
Results: Of the 121 children screened for malaria, 57 (47.1%) tested positive for malaria while 64(52.9%) children tested negative using the Rapid Diagnostic Tests (RDTs). Income status of the family (p<0.001), proximity of homesteads to water sources (p<0.001), insecticide treated mosquito nets usage and its physical conditions (p<0.001) and age of the child (p= 0.002) and the location of the homestead (p= 0.042) are the potential risk factors associated with malaria transmission.
Conclusion: Although many efforts have been done to calm the burden of malaria, the government should empower the village health teams(VHTs) in providing basic malaria diagnosis and community sensitization about the risk factors of malaria, regular distribution of mosquito nets and timely indoor residual spraying.