bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor-stroma ratio as a new prognosticator for pseudomyxoma peritonei: a comprehensive clinicopathological and immunohistochemical study
Authors: Ma Ru , Lin Yu-Lin , Li Xin-Bao , Yan Feng-Cai , Xu Hong-Bin , Peng Zheng , Li Yan
Published: December 2021

Background

As a rare clinical tumor syndrome with an indolent clinical course and lack of pathognomonic symptoms, pseudomyxoma peritonei (PMP) is usually diagnosed at an advanced stage. In-depth pathological analysis is essential to assess tumor biological behaviors, assist treatment decision, and predict the clinical prognosis of PMP. The tumor-stroma ratio (TSR) is a promising prognostic parameter based on the tumor and stroma. This study explored the relationship between TSR and the pathological characteristics and prognosis of PMP.

Methods

PMP patients with complete data who underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy were enrolled. The TSR of postoperative pathological images was quantitatively analyzed by Image-Pro Plus. Then the relationship between TSR and the clinicopathological characteristics, immunohistochemical characteristics and prognosis of PMP was analyzed.

Results

Among the 50 PMP patients included, there were 27 males (54.0%) and 23 females (46.0%), with a median age of 55 (range: 31–76) years. 25 (50.0%) patients were diagnosed with low-grade PMP (LG-PMP), and 25 (50.0%) were diagnosed with high-grade PMP (HG-PMP). There were 4 (8.0%) patients with vascular tumor emboli, 3 (6.0%) patients with nerve invasion, and 5 (10.0%) patients with lymph node metastasis. The immunohistochemical results showed that the Ki67 label index was < 25% in 18 cases (36.0%), 25 - 50% in 18 cases (36.0%) and > 50% in 14 cases (28.0%). The range of TSR was 2 - 24% (median: 8%). The cutoff value of TSR was 10% based on the receiver operating characteristic (ROC) curve and X-Tile analysis. There were 31 (62.0%) cases with TSR < 10% and 19 (38.0%) cases with TSR ≥ 10%. The TSR was closely related to histopathological type (P < 0.001) and Ki67 label index (P < 0.001). Univariate analysis showed that preoperative carcinoembryonic antigen (CEA), preoperative carbohydrate antigen 19–9, pathological type, vascular tumor emboli and TSR influenced the prognosis of PMP patients (P < 0.05). Multivariate analysis showed that preoperative CEA, vascular tumor emboli and the TSR were independent prognostic factors.

Conclusions

The TSR could be a new independent prognosticator for PMP.
Safety and efficacy of the new CryoPop® cryotherapy device for cervical dysplasia in low- and middle-income countries: study protocol for a multicenter open-label non-inferiority clinical trial with historical controls
Authors: Yogeshkumar S. , Anderson Jean , Lu Enriquito , Kenyi Edward , Mensa Margaret , Thaler Katrina , Antartani Ramalingappa , Donimath Kasturi , Patil Basavaraj , Chikaraddi Santosh , Bidri Shailaja , Biradar Aruna , Gudadinni Muttappa R. , Lokare Laxmikant , Yenokyan Gayane , Bellad Mrutyunjaya B. , Goudar Shivaprasad S. , Derman Richard , Revankar Amit , Patil Hema , Wani Ramadevi , Kangle Ranjit , Chavan Ramesh Y. , Nagmoti Mahantesh B. , Kabadi Yogendra M. , Reddy Purushotham , Vernekar Sunita , Hipparagi Surekha , Patil Vijayalaxmi , Dalal Anita
Published: December 2021

Background

Cervical cancer is the fourth most common cancer in the world, affecting mainly women residing in low- and middle-income countries. Progression from a pre-invasive phase to that of an invasive phase generally takes years and provides a window of opportunity to screen for and treat precancerous lesions.

Methods

This study is being conducted at four sites in north Karnataka, India. Community sensitization activities have been organized in the study areas to create awareness among stakeholders, including elected representatives, physicians, health care workers, and potential participants. Organized community based as well as hospital-based screening is being conducted using visual inspection with acetic acid (VIA). Screen positive women are referred to respective study hospitals for colposcopy and directed biopsy. Participants with confirmed high-grade cervical dysplasia (high-grade squamous intraepithelial lesions or HSIL) who fit all other eligibility criteria will be recruited to the study and will receive cryotherapy using CryoPop®, an innovative new cryotherapy device.

Discussion

There is a need to develop an inexpensive, simple, and effective cryotherapy device for use by frontline health care providers at locations where screening and timely treatment can be given, accelerating access to cervical cancer prevention services and minimizing loss to follow-up of women with precancerous lesions who need treatment.

Trial registration

Clinical Trial Registry - India CTRI/2019/01/017289 ClinicalTrials.Gov number NCT04154644. Registered on November 6, 2019.
Does virtual reality increase the efficacy of psychotherapy for young adults with mild-to-moderate depression? A study protocol for a multicenter randomized clinical trial
Authors: Montesano Adrián , Medina Joan C. , Paz Clara , García-Mieres Helena , Niño-Robles Noelia , García-Grau Eugeni , Crespillo Josep Cañete , García-Gutiérrez Alejandro , Alabèrnia-Segura Miquel , Feixas Guillem
Published: December 2021

Background

The improvement of psychological treatments for depression in young adults is a pressing issue highlighted in the literature. Its relevance is determined not only because young adults are underrepresented in research, but also to prevent chronic severe mental health disorders later in life. Engagement is considered a key factor for a good therapeutic outcome, especially among young patients. In this sense, virtual reality could be particularly suited to engage young adults in the therapy process. This project aims to improve the psychological treatment of mild-to-moderate depression in young adults by testing out the efficacy of virtual reality-enhanced personal construct therapy (PCT-VR), as compared to personal construct therapy alone (PCT) and to the reference standard cognitive behavioral therapy (CBT). In contrast to CBT, PCT neither educates patients about depression nor gives them directions on the changes to be made in their dysfunctional behaviors or cognitions. Rather, PCT explores the coherence (or conflicts) of thoughts and behaviors with respect to the person’s sense of identity and focuses on meaning-making processes.

Methods

The efficacy of this innovative intervention (PCT-VR) will be compared to PCT and to CBT in a randomized clinical trial. The study includes an appraisal of therapists’ adherence and independent assessments to preserve internal validity. The Beck Depression Inventory-II is the primary outcome measure for calculating both statistical and clinical significance, but other outcomes will also be assessed (e.g., functioning, well-being, anxiety, stress) at pre- and post-therapy and at 6-month follow-up. The trial will be conducted in a naturalistic context, mostly at the usual health care center of each patient. A sample of 225 participants is targeted to reach enough statistical power to accomplish the goals of the study.

Discussion

We expect that providing evidence for PCT-VR will widen the repertoire of evidence-based technology-based psychotherapeutic interventions for young adults and contribute to the prevention of deteriorating courses of the disorder.

Trial registration

ClinicalTrials.gov NCT04321525. Registered on 18 February 2020
Effect of traditional Chinese medicine formula Guilu Xian on in vitro fertilization and embryo transfer outcome in older women with low prognosis: study protocol for a prospective, multicenter, randomized double-blind study
Authors: Ma Yingjie , Cao Xianling , Song Jingyan , Gao Dandan , Wang Xinlei , Li Li , Sun Zhengao
Published: December 2021

Introduction

In recent years, the prevalence of infertility has significantly increased and has become a global reproductive health problem. The female ovarian reserves have been shown to decrease progressively with an increase in age. Besides, the rate of embryo implantation and clinical pregnancy also decreases. Traditional Chinese medicine has been widely applied in assisted reproductive technology. It is reported to have a significant influence on improving the quality of oocytes, improving endometrial receptivity, increasing clinical pregnancy rate, reducing pregnancy-related complications, etc. Therefore, this study will investigate the effect of Guilu Xian, a traditional Chinese medicine formula on IVF-ET outcome in older women with low prognosis.

Methods and analysis

This trial is a prospective, multicenter, randomized double-blind clinical trial. A total of 120 infertile patients with low prognosis and receiving IVF or ICSI in 3 public hospitals in China will be randomly divided into two parallel groups: Guilu Xian group (n = 60) and placebo group (n = 60). Patients in both groups will be treated with antagonist regimens to promote ovulation, and all the patients will be required to take the medication from the 2nd to 4th day of the menstrual cycle to the day of egg retrieval. A comparison of the total number of oocytes obtained, the fertilization rate, clinical pregnancy rate, embryo quality, embryo implantation rate, and early spontaneous abortion rate between the experimental group and the placebo group will be performed.

Trial registration

Chinese Clinical Trials Registry ChiCTR1900028255. Registered on 16 December 2019.
The role of vitamin D receptor gene polymorphisms in gestational diabetes mellitus susceptibility: a meta-analysis
Authors: Liu Sai
Published: December 2021

Background

Gestational diabetes mellitus (GDM) is a common disease during pregnancy. The association of vitamin D receptor (VDR) polymorphisms with GDM is still controversial. This study aimed to assess the associations between VDR polymorphisms and GDM risk.

Methods

We searched Cochrane Library, PubMed, and Embase electronic database for all eligible studies published from Jan 1, 1980 to December 31, 2020 to conduct a Meta-analysis. We analyzed four VDR polymorphisms: BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), and FokI (rs2228570). Inclusion Criteria: (1) The data can be evaluated; (2) case–control study; and (3) meeting the Hardy–Weinberg’s law. Exclusion criteria: (1) Insufficient or extractable data; (2) Severe publication bias in the data; and (3) duplicate publications. We eventually included 15 studies in seven articles, including 2207 cases and 2706 controls.

Results

We eventually included 15 studies in seven articles, including 2207 cases and 2706 controls. The data showed that ApaI (rs7975232) VDR gene polymorphism was related with the risk of GDM for the comparison of CC vs AA and recessive model in overall population and FokI (rs2228570) VDR gene polymorphism was associated with the risk of GDM for recessive model in overall population. BsmI (rs1544410) polymorphism was not related with the risk of GDM in overall population. However, in the analysis of subgroups grouped by race, BsmI (rs1544410) has certain correlations. And, the data suggested the TaqI (rs731236) polymorphism was not associated with GDM.

Conclusion

Based on the meta-analysis, VDR ApaI (rs7975232) and FokI (rs2228570) polymorphisms increase susceptibility to GDM. In the future, it can be used to diagnose and screen molecular biomarkers for GDM patients.
Mangifera indica as propolis source: what exactly do bees collect?
Authors: Popova Milena , Trusheva Boryana , Ilieva Nia , Thanh Le Nguyen , Lien Nguyen Thi Phuong , Bankova Vassya
Published: December 2021

Objective

The mango tree Mangifera indica is known as one of the botanical sources of propolis in Tropical regions. There are two different materials which bees can collect from a mango tree to produce propolis: the resin of the tree bark, and the latex found on the fruits. We performed the study of the chemical profile of mango resin in comparison with propolis in order to clarify its importance as propolis source.

Results

We compared the chemical profiles (by GC–MS analysis of ethanol extracts after silylation) of the resin and samples of propolis: of stingless bees (3 Vietnames, 2 Indonesian), and one of Apis mellifera from Thailand. In the resin and all propolis samples, 25 compounds were identified: fatty acids, cardanols (alk(en)yl phenols), cardols, anacardic acids, triterpene alcohols and ketones, cycloartane type triterpenic acids. All samples have the same qualitative composition but there are important quantitative differences. Considering literature data on mango latex, we conclude that bees of different species, make use of the two propolis sources offered by mango: bark resin and fruit latex, in different proportions. We also confirmed for the first time the presence of alk(en)yl phenols and anacardic acids in the tree bark resin of mango.
Simultaneous traumatic dislocation of the posterior tibial tendon and long peroneal tendon: a case report
Authors: Riecke Johannes , Müller Max , Bölderl Andreas , Genelin Konstantin
Published: December 2021

Background

Viewing the existing literature, one can find several documents about dislocation of the peroneal tendons. Clinical findings, diagnostics, and therapy are well described. Instead, the list of documents describing dislocations of the posterior tibial tendon is short. We found no case in which a dislocation of both long peroneal tendon and posterior tibial tendon is described.

Case presentation

We present a case of a 29-year-old male patient who sustained an ankle injury after a fall at a boulder gym. He admitted himself with severe pain, tenderness, and swelling of his left ankle. Dislocation of the posterior tibial tendon and simultaneous dislocation of the long peroneal tendon was diagnosed using x-ray, computed tomography, and magnetic resonance imaging. Transosseous suture repair with periosteal augmentation of the flexor retinaculum was performed at the medial malleolus. At the lateral malleolus, transosseous suture was used to repair the superior retinaculum. The ankle was immobilized following surgery. The patient underwent physical therapy afterwards. The treatment resulted in good recovery, and the patient returned to the same level of performance at rock climbing.

Conclusion

Our novel finding is that simultaneously sustained dislocations of the posterior tibial tendon and the long peroneal tendon may occur and can be successfully treated as if each injury is treated individually. Level of evidence Level V, case report.
Delirium and other neuropsychiatric manifestations of COVID-19 infection in people with preexisting psychiatric disorders: a systematic review
Authors: van Reekum Emma A. , Rosic Tea , Sergeant Anjali , Sanger Nitika , Rodrigues Myanca , Rebinsky Reid , Panesar Balpreet , Deck Eve , Kim Nayeon , Woo Julia , D’Elia Alessia , Hillmer Alannah , Dufort Alexander , Sanger Stephanie , Thabane Lehana , Mbuagbaw Lawrence , Samaan Zainab
Published: December 2021

Background

Psychiatric disorders increase risk of neuropsychiatric disease and poor outcomes, yet little is known about the neuropsychiatric manifestations of COVID-19 in the psychiatric population. The primary objective is to synthesize neuropsychiatric outcomes of COVID-19 in people with preexisting psychiatric disorders.

Methods

Data were collected during an ongoing review of the impact of pandemics on people with existing psychiatric disorders. All study designs and gray literature were included. Medline, PsychInfo, CINAHL, EMBASE, and MedRx were searched from inception to September 1 2020. Risk of bias was assessed using a published tool that can accommodate all study types. Two independent authors screened the studies and extracted data. Data were narratively synthesized, as there were insufficient data to meta-analyze. Evidence was appraised according to GRADE.

Results

Four case reports were included, comprising 13 participants from three countries. Many large-sample, relevant papers were omitted for not reporting psychiatric history, despite reporting other comorbidities. Included participants (n = 13) were hospitalized with COVID-19 and appeared to meet criteria for delirium. Myoclonus, rigidity, and alogia were also reported. The most commonly reported preexisting psychiatric diagnoses were mood disorders, schizophrenia, and alcohol use disorder.

Conclusions

People with preexisting psychiatric disorders may experience delirium, rigidity, myoclonus, and alogia during COVID-19 infection; although higher quality and longitudinal data are needed to better understand these phenomena. Relevant COVID-19 literature does not always report psychiatric history, despite heightened neuropsychiatric vulnerability within this population.

Trial Registration: PROSPERO (CRD42020179611).
Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reports
Authors: Kurian Christine J. , French Zachary , Kukulich Patrick , Lankiewicz Matthew , Ghimire Sushil , Maarouf Omar H. , Rizk Sanaa , Rhoades Ruben
Published: December 2021

Background

Atypical hemolytic uremic syndrome is an exceedingly rare thrombotic microangiopathy caused by accelerated activation of the alternative complement pathway.

Case presentation

Here, we report two cases of patients presenting with suspected atypical hemolytic uremic syndrome precipitated by coronavirus disease 2019 infection. The first patient, a 25-year-old Hispanic male, had one prior episode of thrombotic microangiopathy presumed to be atypical hemolytic uremic syndrome precipitated by influenza A, and re-presented with thrombocytopenia, microangiopathic hemolytic anemia, nonoliguric renal failure, and normal ADAMTS13 activity, with confirmed coronavirus disease 2019 positivity. The second patient, a 31-year-old Caucasian female, had no personal history of thrombotic microangiopathy, though reported a family history of suspected atypical hemolytic uremic syndrome. She presented with similar laboratory derangements, oliguric renal failure requiring hemodialysis, and confirmed coronavirus disease 2019 positivity. Both patients were treated with eculizumab with complete resolution of their hematologic and renal complications.

Conclusion

To our knowledge, this represents the largest case series of atypical hemolytic uremic syndrome precipitated by coronavirus disease 2019 in adults.
Parsonage–Turner syndrome following coronavirus disease 2019 immunization with ChAdOx1-S vaccine: a case report and review of the literature
Authors: Vitturi Bruno Kusznir , Grandis Marina , Beltramini Sabrina , Orsi Andrea , Schenone Angelo , Icardi Giancarlo , Durando Paolo
Published: December 2021

Background

Parsonage–Turner syndrome is an acute peripheral neuropathy that affects the upper brachial plexus region. Previously published reports demonstrate that the condition can be triggered by surgery, infection, autoimmune diseases, strenuous exercise, trauma, radiation, and vaccination. Parsonage–Turner syndrome has already been reported in three other patients who were vaccinated against coronavirus disease 2019.

Case presentation

We report the case of a 51-year-old Caucasian man without comorbidities who received the first dose of the ChAdOx1-S recombinant vaccine (Vaxzevria, AstraZeneca, Oxford, UK) against coronavirus disease 2019 and was diagnosed with Parsonage–Turner syndrome. A few days after getting vaccinated, the patient reported a progressive increase in pain in the region of vaccine administration. One month later, the shoulder pain was followed by symptoms of hypoesthesia and muscle weakness on abduction and elevation of the left upper limb. Neurological examination revealed an atrophy of the proximal muscles of the left upper limb, accompanied by paresis of the left deltoid, biceps brachii, triceps brachii, and infraspinatus muscles. Electroneuromyography carried out 3 months after the onset of symptoms showed signs consistent with brachial plexus neuritis. The adverse reaction has been properly reported to the Italian Pharmacovigilance System (Italian Medicines Agency—Agenzia Italiana del Farmaco.

Conclusion

The increased awareness of such association is essential for early identification and diagnosis and, thus, better clinical outcomes.
Urban flood susceptibility evaluation and prediction during 2010–2030 in the southern watersheds of Mashhad city, Iran
Authors: Heidari Elham , Mahmoudzadeh Amir , Mansouri Daneshvar Mohammad Reza
Published: December 2021

Background

Urban flood susceptibility evaluation (FSE) can utilize empirical and rational procedures to focus on the urban flood evaluation using physical coefficients and land-use change ratios. The main aim of the present paper was to evaluate a flood susceptibility model in the southern watersheds of Mashhad city, in Iran, for 2010, 2020, and 2030. The construction of the model depended on the utilization of some global datasets to estimate the runoff coefficients of the watersheds, peak flood discharges, and flood susceptibility evaluations.

Results and conclusions

Based on the climatic precipitation and urban sprawl variation, our results revealed the mean values of the runoff coefficient (Cr) from 0.50 (2010) to 0.65 (2030), where the highest values of Cr (> 0.70) belonged to the watersheds with real estate cover, soil unit of the Mollisols, and the slope ranges over 5–15%. The averagely cumulative flood discharges were estimated from 2.04 m3/s (2010) to 5.76 m3/s (2030), revealing an increase of the flood susceptibility equal 3.2 times with at least requirement of an outlet cross-section by  > 46 m2in 2030. The ROC curves for the model validity explained AUC values averagely over 0.8, exposing the very good performance of the model and excellent sensitivity.
Validating clinical characteristics of primary failure of eruption (PFE) associated with PTH1R variants
Authors: Grippaudo Cristina , D’Apolito Isabella , Cafiero Concetta , Re Agnese , Chiurazzi Pietro , Frazier-Bowers Sylvia A.
Published: December 2021

Background

Primary failure of eruption (PFE) is a hereditary condition, and linkage with variants in the PTH1R gene has been demonstrated in many cases. The clinical severity and expression of PFE is variable, and the genotype–phenotype correlation remains elusive. Further, the similarity between some eruption disorders that are not associated with PTH1R alterations is striking. To better understand the genotype–phenotype correlation, we examined the relationship between the eruption phenotype and PTH1R genotype in 44 patients with suspected PFE and 27 unaffected relatives. Sanger sequencing was employed to analyze carefully selected PFE patients. Potential pathogenicity of variants was evaluated against multiple genetic databases for function prediction and frequency information.

Results

Mutational analysis of the PTH1R coding sequence revealed 14 different variants in 38 individuals (30 patients and 8 first-degree relatives), 9 exonic and 5 intronic. Their pathogenicity has been reported and compared with the number and severity of clinical signs. In 72.7% of patients with pathogenic variants, five clinical and radiographic criteria have been found: involvement of posterior teeth, involvement of the distal teeth to the most mesial affected, supracrestal presentation, altered vertical growth of the alveolar process and posterior open-bite. In cases with mixed dentition (3), the deciduous molars of the affected quadrant were infraoccluded.

Discussion

The probability of an affected patient having a PTH1R variant is greater when five specific clinical characteristics are present. The likelihood of an eruption defect in the absence of specific clinical characteristics is rarely associated with a PTH1R mutation.

Conclusions

We report here that systematic clinical and radiographic observation using a diagnostic rubric is highly valuable in confirming PFE and offers a reliable alternative for accurate diagnosis.
Ionic liquid-based multi-stage sugaring-out extraction of lactic acid from simulated broth and actual lignocellulosic fermentation broth
Authors: Zhou Xu , Sun Yaqin , Zhan Hongjun , Liu Haijun , Wang Xiaoyan , Xu Yang , Li Yi , Xiu Zhilong , Tong Yi
Published: December 2021

In this study, ionic liquid-based sugaring-out extraction was developed to separate lactic acid from the synthetic solution and actual lignocellulosic fermentation broth. Except for [EOHmim]BF4, the ILs with BF4− and OTF− anion can form aqueous two-phase system (ATPS) with the aid of saccharides. With the same kind of saccharides, the ATPS formation ability of ILs could be promoted by increasing the side-chain length of ILs in the order of [Hmim]BF4 ≈ [Bmim]BF4 ˃ [Emim]BF4 due to the decrease in ILs’ kosmotropicity. On the other hand, for the same type of ILs, an ATPS was formed more easily with glucose than with xylose. When IL concentration varied from 35% (w/w) to 40% (w/w) at a low glucose concentration of 15% (w/w), an interesting phase reversal was observed. When lactic acid was undissociated at pH 2.0, 51.8% LA and 92.3% [Bmim]BF4 were partitioned to the top phase, and 97.0% glucose to the bottom phase using an ATPS consisting of 25% (w/w) glucose and 45% (w/w) IL. The total recovery of LA would increase to 89.0% in three-stage sugaring-out extraction from synthetic solution. In three-stage sugaring-out extraction from the filtered and unfiltered fermentation broth obtained via simultaneous saccharification and co-fermentation (SSCF) of acid-pretreated corn stover by the microbial consortium, the total recovery of LA was 89.5% and 89.8%, respectively. Furthermore, the total removal ratio of cells and pigments from the unfiltered broth was 68.4% and 65.4%, respectively. The results support IL-based sugaring-out extraction as a potential method for the recovery of lactic acid from actual fermentation broth.

Graphical Abstract
Porcine ear necrosis in weaned piglets: prevalence and impact on daily weight gain
Authors: Malik Mateusz , Schoos Alexandra , Chantziaras Ilias , Donkers Dries , Croubels Siska , Doupovec Barbara , Maes Dominiek
Published: December 2021

Background

Porcine ear necrosis (PEN) in pigs is characterized by a blue to black discoloration of the tip or margin of the ear followed by necrosis. The present study investigated the prevalence of PEN in a Belgian pig farm with PEN problems in nursery pigs, the effect of a mycotoxin detoxifier added to the feed on PEN prevalence, and the impact of PEN on the piglets’ growth. Six consecutive batches of weaned piglets [565–751 piglets per batch, (n = 3898)] were included. For each weaning batch, the presence and severity of PEN during the nursery period (3–10 weeks of age) were recorded weekly. Average daily gain (ADG) was calculated by weighing 597 individual piglets divided over the six batches. Additionally different mycotoxins were measured in the feed using LC–MS/MS analysis, and to three randomly selected batches, a mycotoxin detoxifier (Mycofix® Plus 5E, Biomin) was added to the feed.

Results

At the end of the nursery period, 11.0–32.0% of the piglets in each batch were affected. The prevalence increased with the number of weeks post-weaning, especially from week 4 after weaning onwards. Mild, moderate, severe and very severe lesions represented 84.6%, 14.0%, 1.3% and 0.1% of all lesions, respectively. Different mycotoxins were present in the feed, but all at low concentrations. The mean ADG (± SD) for pigs without (n = 243) and with (n = 158) lesions was 391 g (± 71 g) and 394 g (± 65 g), respectively (P > 0.05). The ADG for mildly affected (387 g ± 68 g) and moderately affected piglets (420 g ± 44 g) was not significantly different (P > 0.05). The PEN prevalence in the batches without or with the mycotoxin detoxifier was 25% and 22%, respectively (P > 0.05).

Conclusions

Twenty-three percent of animals showed lesions at the end of the nursery. Affected pigs did not have a lower ADG compared to non-affected animals, which might be explained by the fact that most affected piglets only had mild lesions. The addition of a mycotoxin detoxifier did not influence the prevalence of PEN, possibly because of the low levels of mycotoxin contamination. Further research is warranted to assess the impact of more severe PEN lesions and the effect of control measures.
Effect of short glass fiber on shear capacity for shallow wide reinforced concrete beams
Authors: Moawad Mohamed S.
Published: December 2021

Shallow wide reinforced concrete beams are used in modern buildings especially in residential building structures. According to current Egyptian Code Practice 203-2018; the characteristic of a shallow wide concrete beam is that the cross-section width (b) over the effective depth (d) ratio is greater than two and the beam depth is less than 250 mm. Without any shear reinforcing contribution, the applied shear stresses in shallow wide beams must be less than the concrete shear strength. And only concrete provides shear strength. An experimental program was conducted to investigate the contribution of short glass fiber polymer reinforcement to shear strength in shallow wide beams under shear stress. The short glass fiber polymer reinforcement ratio was the main parameter in this study. And also, the contribution of web shear stirrups reinforces against shear stresses. The experimental program consisted of five simply supported reinforced shallow wide concrete beams. Test results show that the use of short glass fiber reinforced polymer has a great effect on shear strength capacity, mode of failure, and ductility of shallow wide concrete beams.
Prevalence of common mental disorders and treatment receipt for people from ethnic minority backgrounds in England: repeated cross-sectional surveys of the general population in 2007 and 2014
Authors: Ahmad Gargie , McManus Sally , Cooper Claudia , Hatch Stephani L. , Das-Munshi Jayati
Published: December 2021

Background

Concerns persist that some ethnic minority groups experience longstanding mental health inequalities in England. It is unclear if these have changed over time.

Aims

To assess the prevalence of common mental disorders (CMDs) and treatment receipt by ethnicity, and changes over time, using data from the nationally representative probability sample in the Adult Psychiatric Morbidity Surveys.

Method

We used survey data from 2007 (n = 7187) and 2014 (n = 7413). A Clinical Interview Schedule – Revised score of ≥12 indicated presence of a CMD. Treatment receipt included current antidepressant use; any counselling or therapy; seeing a general practitioner about mental health; or seeing a community psychiatrist, psychologist or psychiatric nurse, in the past 12 months. Multivariable logistic regression assessed CMD prevalence and treatment receipt by ethnicity.

Results

CMD prevalence was highest in the Black group; ethnic variation was explained by demographic and socioeconomic factors. After adjustment for these factors and CMDs, odds ratios for treatment receipt were lower for the Asian (0.62, 95% CI 0.39−1.00) and White Other (0.58, 95% CI 0.38–0.87) groups in 2014, compared with the White British group; for the Black group, this inequality appeared to be widening over time (2007 treatment receipt odds ratio 0.68, 95% CI 0.38−1.23; 2014 treatment receipt odds ratio 0.23, 95% CI 0.13−0.40; survey year interaction P < 0.0001).

Conclusions

Treatment receipt was lower for all ethnic minority groups compared with the White British group, and lowest among Black people, for whom inequalities appear to be widening over time. Addressing socioeconomic inequality could reduce ethnic inequalities in mental health problems, but this does not explain pronounced treatment inequalities.
A Maternal Serum Metabolite Ratio Predicts Large for Gestational Age Infants at Term: A Prospective Cohort Study
Authors: Sovio Ulla , Goulding Neil , McBride Nancy , Cook Emma , Gaccioli Francesca , Charnock-Jones D Stephen , Lawlor Deborah A , Smith Gordon C S
Published: December 2021

Context

Excessive birth weight is associated with maternal and neonatal complications. However, ultrasonically estimated large for gestational age (LGA; >90th percentile) predicts these complications poorly.

Objective

To determine whether a maternal serum metabolite ratio developed for fetal growth restriction (FGR) is predictive of birth weight across the whole range, including LGA at birth.

Methods

Metabolites were measured using ultrahigh performance liquid chromatography-tandem mass spectroscopy. The 4-metabolite ratio was previously derived from an analysis of FGR cases and a random subcohort from the Pregnancy Outcome Prediction study. Here, we evaluated its relationship at 36 weeks of gestational age (wkGA) with birth weight in the subcohort (n = 281). External validation in the Born in Bradford (BiB) study (n = 2366) used the metabolite ratio at 24 to 28 wkGA.

Results

The inverse of the metabolite ratio at 36 wkGA predicted LGA at term [the area under the receiver operating characteristic curve (AUROCC) = 0.82, 95% CI 0.73 to 0.91, P = 6.7 × 10−5]. The ratio was also inversely associated with birth weight z score (linear regression, beta = −0.29 SD, P = 2.1 × 10−8). Analysis in the BiB cohort confirmed that the ratio at 24 to 28 wkGA predicted LGA (AUROCC = 0.60, 95% CI 0.54 to 0.67, P = 8.6 × 10−5) and was inversely associated with birth weight z score (beta = −0.12 SD, P = 1.3 × 10−9).

Conclusions

A metabolite ratio which is strongly predictive of FGR is equally predictive of LGA birth weight and is inversely associated with birth weight across the whole range.
Noninvasive Prenatal Diagnosis of a Paternally Inherited MEN1 Pathogenic Splicing Variant
Authors: Huby Thomas , Le Guillou Edouard , Burin des Roziers Cyril , Pacot Laurence , Briand-Suleau Audrey , Chansavang Albain , Toussaint Aurélie , Duchossoy Véronique , Vaucouleur Nicolas , Benoit Virginie , Lodé Laurence , Molac Clémence , North Marie-Odile , Grotto Sarah , Tsatsaris Vassilis , Jouinot Anne , Cochand-Priollet Béatrix , Paepegaey Anne-Cécile , Nectoux Juliette , Groussin Lionel , Pasmant Eric
Published: December 2021

Context

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the tumor suppressor gene MEN1. The uncertainty of pathogenicity of MEN1 variants complexifies the selection of the patients likely to benefit from specific care.

Objective

MEN1-mutated patients should be offered tailored tumor screening and genetic counseling. We present a patient with hyperparathyroidism for whom genetic analysis identified a variant of uncertain significance in the MEN1 gene (NM_130799.2): c.654G > T p.(Arg218=). Additional functional genetic tests were performed to classify the variant as pathogenic and allowed prenatal testing.

Design

Targeted next generation sequencing identified a synonymous variant in the MEN1 gene in a 26-year-old male with symptomatic primary hyperparathyroidism. In silico and in vitro genetic tests were performed to assess variant pathogenicity.

Results

Genetic testing of the proband’s unaffected parents showed the variant occurred de novo. Transcript study showed a splicing defect leading to an in-frame deletion. The classification of the MEN1 variant as pathogenic confirmed the diagnosis of MEN1 and recommended an adapted medical care and follow-up. Pathogenic classification also allowed to propose a genetic counseling to the proband and his wife. Noninvasive prenatal diagnosis was performed with a personalized medicine-based protocol by detection of the paternally inherited variant in maternal plasmatic cell free DNA, using digital PCR.

Conclusion

We showed that functional genetic analysis can help to assess the pathogenicity of a MEN1 variant with crucial consequences for medical care and genetic counseling decisions.
Digital Workers, Urban Vectors, and New Economies
Authors: Kuriakose Francis , Iyer Deepa Kylasam
Published: December 2021

Platform capitalism has enabled digital platforms to bring producers, consumers, and workers in a multisided marketplace with the purpose of collecting data. The resulting commodification of materiality and sociality in the digital sphere and the proprietary control of data open opportunities for value creation and realization, quite distinct from the value propositions of industrial manufacturing. As the relationship between value generation and human labor becomes tenuous or invisible, management strategies to appropriate value extends beyond labor control to direct appropriation. This article explores how labor responds to such devices of control and appropriation by digital platforms. Using the typological approach, the study argues that labor resistance emerges as a direct response to the management strategies of platforms in the form of granular resistance, data activism, trade unions and workers’ organization, and collective ownership.
Cohort, Policy, and Process: The Implications for Migrant Fertility in West Germany
Authors: Erman Jeylan
Published: December 2021

Although a growing literature explores the relationship between migration and fertility, far less scholarship has examined how migrant childbearing varies over time, including across migrant cohorts. I extend previous research by exploring migrant-cohort differences in fertility and the role of changing composition by education and type of family migration. Using 1984–2016 German Socio-Economic Panel data, I investigate the transition into first, second, and third birth among foreign-born women in West Germany. Results from an event-history analysis reveal that education and type of family migration—including marriage migration and family reunions—contribute to differences in first birth across migrant cohorts. Specifically, more rapid entry into first birth among recent migrants from Turkey stems from a greater representation of marriage migrants across arrival cohorts, while increasing education is associated with reduced first birth propensities among recent migrants from Southern Europe. I also find variation in the risk of higher parity transitions across migrant cohorts, particularly lower third birth risks among recent arrivals from Turkey, likely a result of changing exposures within origin and destination contexts. These findings suggest that as political and socioeconomic circumstances vary within origin and destination contexts, selection, adaptation, and socialization processes jointly shape childbearing behavior.
Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review
Authors: Whitehouse Daniel P. , Vile Alexander R. , Adatia Krishma , Herlekar Rahul , Roy Akangsha Sur , Mondello Stefania , Czeiter Endre , Amrein Krisztina , Büki András , Maas Andrew I. R. , Menon David K. , Newcombe Virginia F. J.
Published: December 2021

BACKGROUND:

Blood biomarkers are of increasing importance in the diagnosis and assessment of traumatic brain injury (TBI). However, the relationship between them and lesions seen on imaging remains unclear.

OBJECTIVE:

To perform a systematic review of the relationship between blood biomarkers and intracranial lesion types, intracranial lesion injury patterns, volume/number of intracranial lesions, and imaging classification systems.

METHODS:

We searched Medical Literature Analysis and Retrieval System Online, Excerpta Medica dataBASE, and Cumulative Index to Nursing and Allied Health Literature from inception to May 2021, and the references of included studies were also screened. Heterogeneity in study design, biomarker types, imaging modalities, and analyses inhibited quantitative analysis, with a qualitative synthesis presented.

RESULTS:

Fifty-nine papers were included assessing one or more biomarker to imaging comparisons per paper: 30 assessed imaging classifications or injury patterns, 28 assessed lesion type, and 11 assessed lesion volume or number. Biomarker concentrations were associated with the burden of brain injury, as assessed by increasing intracranial lesion volume, increasing numbers of traumatic intracranial lesions, and positive correlations with imaging classification scores. There were inconsistent findings associating different biomarkers with specific imaging phenotypes including diffuse axonal injury, cerebral edema, and intracranial hemorrhage.

CONCLUSION:

Blood-based biomarker concentrations after TBI are consistently demonstrated to correlate burden of intracranial disease. The relation with specific injury types is unclear suggesting a lack of diagnostic specificity and/or is the result of the complex and heterogeneous nature of TBI.
Comparative analysis of vertebrates reveals that mouse primordial oocytes do not contain a Balbiani body
Authors: Dhandapani Laasya , Salzer Marion C. , Duran Juan M. , Zaffagnini Gabriele , De Guirior Cristian , Martínez-Zamora Maria Angeles , Böke Elvan
Published: December 2021

Oocytes spend the majority of their lifetime in a primordial state. The cellular and molecular biology of primordial oocytes is largely unexplored; yet, it is necessary to study them to understand the mechanisms through which oocytes maintain cellular fitness for decades, and why they eventually fail with age. Here, we develop enabling methods for live-imaging-based comparative characterization of Xenopus, mouse and human primordial oocytes. We show that primordial oocytes in all three vertebrate species contain active mitochondria, Golgi and lysosomes. We further demonstrate that human and Xenopus oocytes have a Balbiani body characterized by a dense accumulation of mitochondria in their cytoplasm. However, despite previous reports, we did not find a Balbiani body in mouse oocytes. Instead, we demonstrate that what was previously used as a marker for the Balbiani body in mouse primordial oocytes is in fact a ring-shaped Golgi that is not functionally associated with oocyte dormancy. This study provides the first insights into the organization of the cytoplasm in mammalian primordial oocytes, and clarifies the relative advantages and limitations of choosing different model organisms for studying oocyte dormancy.
The relationship between head shape, head musculature and bite force in caecilians (Amphibia: Gymnophiona)
Authors: Lowie Aurélien , De Kegel Barbara , Wilkinson Mark , Measey John , O'Reilly James C. , Kley Nathan J. , Gaucher Philippe , Brecko Jonathan , Kleinteich Thomas , Adriaens Dominique , Herrel Anthony
Published: December 2021

Caecilians are enigmatic limbless amphibians that, with a few exceptions, all have an at least partly burrowing lifestyle. Although it has been suggested that caecilian evolution resulted in sturdy and compact skulls as an adaptation to their head-first burrowing habits, no relationship between skull shape and burrowing performance has been demonstrated to date. However, the unique dual jaw-closing mechanism and the osteological variability of their temporal region suggest a potential relationship between skull shape and feeding mechanics. Here, we explored the relationships between skull shape, head musculature and in vivo bite forces. Although there is a correlation between bite force and external head shape, no relationship between bite force and skull shape could be detected. Whereas our data suggest that muscles are the principal drivers of variation in bite force, the shape of the skull is constrained by factors other than demands for bite force generation. However, a strong covariation between the cranium and mandible exists. Moreover, both cranium and mandible shape covary with jaw muscle architecture. Caecilians show a gradient between species with a long retroarticular process associated with a large and pennate-fibered m. interhyoideus posterior and species with a short process but long and parallel-fibered jaw adductors. Our results demonstrate the complexity of the relationship between form and function of this jaw system. Further studies that focus on factors such as gape distance or jaw velocity will be needed in order to fully understand the evolution of feeding mechanics in caecilians.
Paediatric diagnostic reference levels for common radiological examinations using the European guidelines
Authors: Almén Anja , Guðjónsdóttir Jónína , Heimland Nils , Højgaard Britta , Waltenburg Hanne , Widmark Anders
Published: December 2021

Objective:

The purpose of this study was to explore the feasibility to determine regional diagnostic reference levels (RDRLs) for paediatric conventional and CT examinations using the European guidelines and to compare RDRLs derived from weight and age groups, respectively.

Methods:

Data were collected from 31 hospitals in 4 countries, for 7 examination types for a total of 2978 patients. RDRLs were derived for each weight and age group, respectively, when the total number of patients exceeded 15.

Results:

It was possible to derive RDRLs for most, but not all, weight-based and age-based groups for the seven examinations. The result using weight-based and age-based groups differed substantially. The RDRLs were lower than or equal to the European and recently published national DRLs.

Conclusion:

It is feasible to derive RDRLs. However, a thorough review of the clinical indications and methodologies has to be performed previous to data collection. This study does not support the notion that DRLs derived using age and weight groups are exchangeable.

Advances in knowledge:

Paediatric DRLs should be derived using weight-based groups with access to the actual weight of the patients. DRLs developed using weight differ markedly from those developed with the use of age. There is still a need to harmonize the method to derive solid DRLs for paediatric radiological examinations.
Gregg Jones, Ostatni bastion w Khe Sanh. Godzina chwały amerykańskich marines w Wietnamie, tłum. Stanisław Powała-Niedźwiecki, Czerwonak 2020, pp. 491.
Authors: Benken Przemysław
Published: December 2021

recenzja książki
Miasto i/czy zbrodnia Znaczenie scenerii miejskiej dla teorii powieści kryminalnej
Authors: Graf Magdalena , Graf Paweł
Published: December 2021

Tematem artykułu jest analiza związków zachodzących między powieścią kryminalną a wpisanym w nią miastem. Miasto rozumiane jest zarówno jako byt literacki, jak i realna przestrzeń, ze swoją toponimią i antroponimią, aksjologią i historią. Jako byt realno-fikcjonalny staje się ono w kryminale elementem tej samej wagi, co zbrodnia i detektyw. Interpretacje tematu miasta zostały poprzedzone czteroelementową typologią istotnych odmian lektury powieści kryminalnej sporządzoną na podstawie analizy stanu badań. Odmiany te wskazane zostały ze względu na główny podejmowany w nich problem, którym jest kolejno: poetyka powieści, historia gatunku, ujęcie antropologiczne i ujęcia socjologiczne. Omówione zostały m.in. propozycje Stanco Lasića, StanisławaBarańczaka, Rogera Caillois i Helmuta Heissenbüttela. Autorzy proponują też własną interpretację kryminału miejskiego na podstawie analizy poznańskich powieści kryminalnych Piotra Bojarskiego, pokazując, że nowe spojrzenie na miasto pozwala wyprowadzić powieść kryminalną ze schematycznych rozwiązań, w których tkwi ten gatunek powieści.
RESEARCH ON THE IMPACT OF INTERNET MEDIA ON EPIDEMIC PREVENTION AND CONTROL
Authors: ZHANG FAN , LI JIA-HUI
Published: December 2021

At the beginning of 2020, COVID-19 broke out. After the COVID-19 outbreak, online media became an important channel for the masses to obtain information about the epidemic. According to the different social functions of various online media, this paper classifies the important online media in this epidemic into four categories, namely, official media, government media, market-oriented media and We-media. By using the crawler software tool, crawling the Weibo data of the People’s Daily, The Paper, Healthy China, and Doctor Do of Concord, from January 1, 2020, to March 1, 2020, combined with the data of confirmed cases of the domestic novel coronavirus epidemic in the same period, constructed a multiple regression model to conduct empirical research on the effects of online media on different subjects. The research results show that official new media and market-based media are negatively correlated with the number of people infected with the epidemic, whereas government media are more inclined to reflect the law of the development of the epidemic and are positively correlated with the development of the epidemic. Therefore, taking the initiative to grasp the public opinion guidance of the official media and market-oriented media can achieve better publicity effect in the epidemic prevention and control work.