bluuebunny/crossref_metadata_2025 huggingface dataset:
Value of Immunological Biomarkers in Early Prediction of Bacillus Calmette-Guerin Failure in High-Risk Non-muscle-invasive Bladder Cancer
Authors: Mohamed G.A. El-Gazzar Mohamed , Abol-Enein Hassan , Amira Awadalla3 Amira , Ahmed El-Assmy Ahmed , Ahmed El-Assmy Ahmed , S. El-Ghreb Mohamed S. El-Ghreb , A.A. Barakat Lamiaa , A.F. Abdel-Aziz Lamiaa
Published: October 2023

Objectives To investigate the predictive value of different immunological markers on treatment outcomes after bacillus Calmette-Guerin (BCG) induction in high-risk non-muscle-invasive bladder cancer (NMIBC).
Patients and Methods Patients who underwent transurethral resection of bladder tumors for NMIBC were assessed for study eligibility. Urine and blood samples were taken from patients at baseline (immediately before the first dose of induction). Urine samples were evaluated for interleukin (IL)-6, IL-8, IL-10, IL-11, and interferon- γ by solid-phase enzyme-linked immunosorbent assay (ELISA). Blood samples were evaluated for epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2) using quantitative reverse transcriptase-polymerase chain reaction analysis. Each marker was assessed in relation to tumor recurrence.
Results Between June 2016 and December 2019, 160 patients were included. Tumor recurrence occurred in 47 (29.38%) patients over a median (IQR) follow-up of 24 (12: 49) months. Using univariate analysis, the following urinary cytokines were associated with higher recurrence: urinary IL-6, 8, 10, 11, and interferon-γ. Also, serum EGFR and HER2 were associated with higher recurrence. On multivariate Cox regression analysis, significant variables include HER2 [HR (95%CI): 2.675 (1.367-5.233), p= 0.004], and IL-11 [HR (95%CI): 0.889 (0.825-0.957), p= 0.002].
Conclusions Serum HER2 and urinary IL-11 could be applied in clinical practice to predict BCG failure in patients with high-risk NMIBC, so those patients could be offered other modalities (radical cystectomy) early with better survival. Further studies are recommended to establish their exact role.
Spatial and Narrative Escape in Fae Myenne Ng’s Bone
Authors: Zhang Huichan
Published: October 2023

Bone is the impressive first novel written by Fae Myenne Ng, a first-generation Chinese American woman writer. Under the guidance of Gaston Bachelard’s and M. M. Bakhtin’s theories of space and Gérard Genette’s theories of narrative discourse, this paper probes into the narrative space and time in Ng’s Bone, trying to detect the protagonist’s escape consciousness revealed in the form of spatial and narrative escape. Leila’s individual escape, which derives from the family tragedy under the exploitation and expulsion of racial minorities in America, is, in fact, the epitome of every anxious Chinese American’s impulse to run away.
Incidence of Trauma during Birth to Neonates Born to Mothers with Gestational Diabetes Mellitus
Authors: Haider Ali , Mahdawi Esam Nedhal , Nasef Minoosh , Shatla Emad , Nair Arun
Published: October 2023

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that occurs during pregnancy. The incidence of GDM has been on the rise and is a significant cause of various consequences for both the mother and infant. Such consequences include birth trauma. Factors such as shoulder dystocia and fetal macrosomia can increase the incidence of birth trauma. Additionally, GDM is a major cause of fetal macrosomia, influencing the intrapartum delivery method. This study aims to investigate the incidence of birth trauma in mothers with and without GDM. A total of 10,865 patients from King Hamad University Hospital (KHUH) were included, and their files were then further stratified only to include neonates with evidence of birth trauma. A total of 64 patients were found to fit the inclusion criteria. The study looked at GDM status, gestational age, birth weight, length, head circumference, mode of delivery, presentation of the baby before delivery, assistance during delivery, and maternal/neonatal trauma. Maternal trauma rates were found to be statistically significant within the population of the Kingdom of Bahrain. An increased incidence of maternal trauma was observed in the non-GDM group, with 56.3% of the patients requiring an episiotomy or having a complication of a vaginal laceration. Regarding the incidence of birth traumas in the GDM group, they presented most commonly with cephalohematoma or Erb’s palsy, whereas the non-GDM group most commonly presented with cephalohematoma. The incidence of birth trauma due to GDM has seldom been researched in the existing literature. However, it has been noted that factors such as macrosomia can increase the likelihood of birth trauma. The general incidence of neonatal birth trauma has been reported to be 2.7%, which is reassuring; however, it is essential to investigate further the effect of GDM on the rates of birth trauma using large population cohorts.
EXPLORING THE MODIFIED GAMMA FRAILTY DISTRIBUTION: AN OPTIMAL DESIGN APPROACH USING PYTHON
Authors: Abdulazeez Sikiru Adeyinka
Published: October 2023

A suction/injection controlled mixed convection flow of an incompressible and viscous fluid in a vertical SurvivalAnalysis is pivotal in understanding the effects of covariates on potentially censored failure times and in the joint modelling of clustered data. It is used in the context of incomplete repeated measures and failure times in longitudinal studies. Survival data are often subject to right censoring and to a subsequent loss of information about the effect of explanatory variables. Frailty models are one common approach to handle such data.Three frailty models are used to analyze bivariate time-to-event data. All approaches accommodate right censored lifetime data and account for heterogeneity in the study population. A Modified Gamma Frailty Model is compared with two existing Frailty Models. The survival-analysis was performed using the Python.The newly derived MGF was analyzed using Python which is more robust when sample size is more than forty.The MGF model performs better than the existing models in the presence of clustering. However the CGF is preferable in the absence of clusters in a given data set.
Stabilization of Clayey Soil with Alkali-activated Hybrid Slag/Cement
Authors: Yıldırım Eray , Bol Ertan , Avcı Eyübhan , Özocak Aşkın
Published: October 2023

This study investigates the stabilization performance of clayey soil treated with alkali-activated hybrid slag/cement. Sodium silicate (SS) and sodium hydroxide (SH) are used as alkali activators, whereas ground blast furnace slag (GGBS) and ordinary Portland cement (OPC) are used as sources of aluminosilicate. A total of 27 different types of mixtures are used for stabilization. Unconfined compressive strength (UCS) of untreated clay and stabilized soils are performed at immediately, 3-, 7-, 28-, and 90 days curing times under air-dried and wet-cured conditions. In addition, 90-d volume and mass changes in the samples are measured. Stabilized samples with an SS/SH ratio of 1 under air-dried conditions reveal moistening at early curing ages (≤28 days); afterward, sodium carbonate crystals appear in these samples at longer curing ages. Geopolymer-treated clayey soil exhibits lower volumetric and mass changes compared with OPC. Most of the stabilized clayey soil with alkali-activated hybrid slag/cement exhibits higher strength compared with OPC under air-dried and wet-cured conditions.
Effects of Tire Crumb Rubber and Steel Fiber on Punching Shear Behavior of Two-way Alkali-activated Concrete Flat Slabs
Authors: Eren Necip Altay , Çevik Abdulkadir
Published: October 2023

As a result of the rapid increase in the demand for transportation vehicles recently, the accumulation of waste tires causes environmental problems. One of the methods that can contribute to the reduction of this environmental problem is the recycling of waste tires as a construction material in aggregate form. This research investigated the impacts of waste tire crumb rubber with/out steel fiber (SF) on the two-way punching-shear behavior alkali-activated concrete (AAC) flat slabs and performed center point load tests. In the study, one-type of SF and two kinds of scrap tire waste i.e., crumb rubber (CR) and tire particles, were used on the producing of rubberized AAC slabs obtained by 100% as binder made of ground-granulated blast furnace slag (GGBFS). Also, while both fine crumb rubber (FCR) and coarse crumb rubber (CCR) were used together in the AAC slabs, tire crumb rubber (TCR) was used alone at the same proportion. Additionally, the fine aggregate was substituted with 10% and 15% FCR and CCR, and coarse aggregate was substituted with TCR in the same proportions. Additionally, AAC slabs with recycled tire rubber (RTR) were produced as fibrous and non-fibrous using 1% by volume hook-end SF. In total, nine AAC slabs with sizes of 50 x 50 x 6 cm3 were manufactured for the study. Experimental data showed that the inclusion of RTR only slightly reduced the punching shear strength of AAC slabs and the punching shear strength of the slabs increased when SF was added to the mixtures containing RTR.
Estimation of the Poisson's Ratio of the Rock Mass
Authors: Narimani Samad , Davarpanah Seyed Motreza , Vásárhelyi Balázs
Published: October 2023

The value of Poisson's ratio is a crucial parameter in rock mechanics and engineering for both intact rock and rock mass. Poisson's ratio has not gotten the attention it merits compared to other essential mechanical characteristics of intact rock and rock mass. Limited relationships exist between rock mass classification systems (such as RMR, RMQR, Q, and GSI) and Poisson's ratio. This paper provides a comprehensive review of models proposed by various researchers for estimating Poisson's ratio for rock mass. The different methods are compared, and new general equations are derived. The results indicate that the Poisson's ratio value of rock mass is inversely proportional to its quality and strength and depends on the Poisson's ratio value of the intact rock. Specifically, a linear equation is obtained using the RMR or GSI system, showing that the Poisson's ratio increases as the quality and strength of the rock mass decrease. The Q system has a logarithmic link between the rock mass quality and Poisson's ratio. It should be noted that the derived equations are applicable only under the assumption of a homogeneous isotropic rock mass.
Einseitig erklärter Eigentumsvorbehalt und Käuferinsolvenz
Authors:   https://doi.org/10.33196/9783704674425, Riss Olaf
Published: October 2023

Klärung wesentlicher Rechtsfragen rund um den Eigentumsvorbehalt Als Sicherungsinstrument für den Warenkredit erfreut sich der Eigentumsvorbehalt großer Beliebtheit. Allerdings stören mehrere Ungereimtheiten seine dogmatische Einbettung. Nicht zufriedenstellend beantwortet ist etwa, wie sich der Eigentumsvorbehalt mit dem Faustpfandprinzip verträgt. Zahlreiche weitere Fragen erheben sich beim einseitig erklärten Eigentumsvorbehalt: Fehlt es dem Kaufvertrag an einer wirksamen Vorbehaltsabrede, versucht der kreditierende Verkäufer nicht selten, dieses Versäumnis nachträglich zu sanieren. Er erklärt bei Übergabe – typischerweise durch Vermerk auf Lieferschein oder Faktura –, das Eigentum an der übergebenen Sache solle entgegen der gesetzlichen Regel (§ 1063 ABGB) nicht vor vollständiger Kaufpreiszahlung auf den Käufer übergehen. Stimmt der Käufer diesem Angebot auf Vertragsänderung nicht zu, spricht man vom einseitig erklärten Eigentumsvorbehalt. Eine solche Konstellation ist an der Schnittstelle mehrerer Rechtsgebiete angesiedelt: dem Allgemeinen Teil des Bürgerlichen Rechts, dem Sachenrecht, dem Schuldrecht, dem Insolvenzrecht und nicht zuletzt dem Unternehmensrecht sowie dem Exekutionsrecht. Die Untersuchung entwickelt einen ganzheitlichen Ansatz, der die spezifischen Prinzipien aller dieser Materien einbezieht. Zentrale Fragen sind dabei, ob das Synallagma in der Käuferinsolvenz trotz Vorleistungspflicht gesichert bleibt und ob die einseitige Vorbehaltserklärung eine anfechtbare Rechtshandlung (§§ 27 ff IO) ist.
Pengaruh Model Pembelajaran Project Based Learning terhadap Keterampilan Proses Sains pada Ta Makanan di Sekitarmu Kelas VIII
Authors: Amanda Niken Gusti , Biru Lulu Tunjung , Suryani Dwi Indah
Published: October 2023

Penelitian ini dilatar belakangi karena kurangnya kegiatan praktikum yang dilaksanakan serta masih kurangnya penggunaan model pembelajaran berbasis proyek, oleh karena itu siswa mengalami kesulitan dalam materi pada tema makanan di sekitarku serta kurangnya kemampuan proses sains siswa kelas VIII. Tujuan penelitian ini yaitu menganalisis pengaruh model pembelajaran berbasis proyek (PjBL) tema makanan di sekitarku. Pengumpulan data menggunakan metode quasi eksperimental desain, dengan jenis non equivalent control group dan desain ini menggunakan pre test dan post test pada kelas eksperimen dan kelas kontrol. Instrumen penelitian yang diterapkan ialah lembar tes, observasi, wawancara dan validasi.Model pembelajaran berbasis proyek dikembangkan melalui tahap-tahap antara lain yaitu menyajikan pertanyaan-pertanyaan mendasar, (2) membuat perencanaan proyek, (3) membuat jadwal kegiatan, (4) menilai perkembangan siswa dalam mengerjakan proyeknya (memantau), (5) meninjau hasil tes, dan (6) evaluasi. Dari penelitian ini model pembelajaran project based learning (PjBL) memiliki pengaruh terhadap kemampuan proses sains yang ditunjukan melalui nilai signifikansi yaitu 0,002 < 0,05 yang menunjukkan H1 diterima maka H0 ditolak.
PENGGUNAAN ALAT PERAGA PADA MATERI BUMI DAN TATA SURYA UNTUK MENINGKATKAN PEMAHAMAN IPA KELAS VII-D SMP NEGERI 1 GEDANGAN
Authors: Salamah Afifah Naura , Warmi'anah Warmi'anah , Setiawan Agung Mulyo
Published: October 2023

Penelitian ini memiliki tujuan untuk meningkatkan pemahaman IPA materi Bumi dan Tata Surya melalui penggunaan alat peraga. Jenis penelitian ini yakni penelitian tindakan kelas kolaboratif antara peneliti dengan guru. Siklus dalam penelitian ini berjumlah dua dengan masing-masing 4 tahapan yakni perencanaan, tindakan, observasi dan refleksi. Teknik pengumpulan data yang dilakukan yakni lembar observasi serta tes. Analisis data dilakukan secara deskriptif kuantitatif untuk lembar observasi dan post test. Hasil penelitian berupa rata-rata nilai pada siklus I pertemuan 1 dan 2 berturut-turut sebesar 70,91 dan 75,76. Adapun rata-rata nilai pada siklus II pertemuan 1 dan 2 berturut-turut sebesar 78,82 dan 81,86. Kesimpulan dari penelitian ini adalah alat peraga dapat meningkatkan pemahaman IPA materi Bumi dan Tata Surya di kelas VII-D SMP Negeri 1 Gedangan.
Efektivitas Pembelajaran Offline Pada Mata Kuliah Matematika Pasca Pandemi
Authors: Krisna Evi dwi
Published: October 2023

Tujuan dari penelitian ini adalah untuk mengevaluasi efektivitas pembelajaran offline pasca pandemi di INSTIKI pada mata kuliah matematika. Penelitian ini merupakan penelitian kualitatif deskriptif, dimana populasinya adalah seluruh mahasiswa INSTIKI yang mendapat mata kuliah matematika menggunakan

 pembelajaran offline pasca pandemi. Didapatkan 60 mahasiswa INSTIKI sebagai sampel subyek penelitian, yang dipilih dengan cluster random sampling. Pembelajaran offline secara penuh dilakukan oleh subyek penelitian dengan tatap muka secara langsung dengan dosen di kelas. Kuisioner dibagikan untuk pengumpulan data melalui media google form, dan dianalisis dengan statistik deskriptif. Evaluasi keefektivitasan dari kembali diterapkannnya pembelajaran offline ini ditinjau dari aspek kepuasan dan pemahaman materi yang diajarkan. Dari aspek kepuasan, kembalinya pelaksanaan model pembelajaran offline ini memberi dampak positif, terlihat dari 81,67% menjawab sangat puas, 11,67% puas, dan 5,00% merasa cukup puas. Hanya 1,67% yang merasa kurang puas dan tidak ada yang merasa sangat tidak puas. Dari aspek pemahaman materi yang diajarkan juga menunjukkan hasil yang baik dengan kembalinya pembelajaran secara offline ini. Sebesar 63,33% menjawab mudah, bahkan 18,33% menjawab sangat mudah, dan 15,00% yang menjawab cukup mudah memahami. Hanya 3,33% yang merasa sulit, dan tidak ada yang menjawab sangat sulit memahami materi yang diajarkan dengan pembelajaran offline ini. Jadi dapat disimpulkan bahwa kembalinya dilaksanakannya pembelajaran secara offline pasca pandemi adalah efektif, baik dari aspek kepuasan maupun pemahaman.
Penerapan Model Missouri Mathematics Project Terhadap Hasil Belajar Matematika
Authors: Suryati Kadek , Putri Ni Wayan Suardiati
Published: October 2023

Pembelajaran yang bersifat menoton akan menjadikan mahasiswa menjadi pasif dan hanya penerima konsep. Tujuan dari penelitian ini adalah untuk mendeskripsikan model pembelajaran Missouri Mathematics Project (MMP) dalam meningkatkan hasil belajar pada mata kuliah matematika komputer. Penelitian ini dilaksanakan di kampus Institut Bisnis dan Teknologi Indonesia (INSTIKI). Subjek dalam penelitian ini adalah mahasiswa semester satu jurusan Teknik Informatika Kelas C tahun ajaran 2022/2023 sebanyak 30 mahasiswa. Metode pengumpulan data yang digunakan adalah wawancara, observasi, metode angket dan tes. Teknik analisis data menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa  peningkatan hasil belajar matematika pada mahasiswa jurusan teknik informatika dari siklus I diperoleh rata-rata nilai tes matematika sebesar 67,23 dengan jumlah mahasiswa yang mengikuti tes sebanyak 30 orang. Dari 30 mahasiswa tersebut 21 mahasiswa masih mendapatkan nilai dalam kategori kurang dan 9 orang dengan kategori baik dan meningkat di siklus ke II rata-rata nilai sebesar 73,83 dengan jumlah mahasiswa yang mengikuti tes sebanyak 30 orang. Dari 30 mahasiswa tersebut 18 mahasiswa masih mendapatkan nilai dalam kategori baik, 7 mahasiswa mendapatkan kategori cukup dan 5 orang dengan kategori kurang. Sedangkan untuk hasil respon mahasiswa terhadap model pembelajaran MMP mendapatkan respon positif sebesar 80% dan respon negative sebesar 20%.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS VIDEO ANIMASI “AFIKA” UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PADA MATERI IMPULS DAN MOMENTUM
Authors: Rahmaniyah Nauly , Anggaryani Mita
Published: October 2023

Penelitian ini mengembangkan media pembelajaran berbasis video animasi yaitu AFIKA. AFIKA secara khusus berfokus pada impuls dan momentum sebagai topik pembelajaran. Penelitian ini bertujuan untuk meningkatkan hasil belajar peserta didik dan memastikan kelayakan media AFIKA yang diterapkan di kelas. Penelitian ini mendeskripsikan penilaian validitas, penilaian keterlaksanaan kegiatan pembelajaran menggunakan AFIKA, dan hasil belajar yang diperoleh dari penilaian pre-test dan post-test. Penelitian ini menerapkan model pengembangan PIE yang terdiri dari tiga tahapan yaitu Plan (perencanaan), Implementation (pelaksanaan), dan Evaluate (evaluasi). Pengumpulan data dilakukan melalui keahlian validator untuk menentukan validitas media; Pengamat bertanggung jawab untuk memantau dan menilai keterlaksanaan kegiatan pembelajaran di kelas; Peserta didik memberikan umpan balik melalui angket respon, dan hasil belajar peserta didik dinilai melalui penilaian pre-test dan post-test. Sebanyak 32 peserta didik dari kelas X-3 salah satu SMA Islam di Gresik sebagai partisipan. Instrumen penelitian menggunakan skala likert untuk menghitung penskoran. Hasil dari penelitian pengembangan yang dilakukan menunjukkan bahwa media AFIKA yang berfokus pada topik impuls dan momentum dalam fisika memperoleh skor validitas sebesar 98,99% pada aspek materi, media, dan bahasa, menunjukkan tingkat validitas yang tinggi. Keterlaksanaan kegiatan pembelajaran menggunakan media AFIKA di kelas X-3 sangat berhasil mencapai persentase 98,66%. Secara keseluruhan respon peserta didik terhadap media AFIKA adalah positif. Terdapat peningkatan hasil belajar peserta didik kelas X-3 pada materi fisika impuls dan momentum setelah penerapan media AFIKA, dengan rata-rata N-Gain sebesar 0,288 yang menunjukkan tingkat peningkatan yang rendah. Hasil penelitian menunjukkan bahwa media video animasi AFIKA pada materi impuls dan momentum praktis dan layak untuk diterapkan. Namun, hal itu mungkin berdampak terbatas pada peningkatan hasil belajar, yang dapat dipengaruhi oleh berbagai faktor.
Pengembangan Media Pembelajaran Flippbook Model Hybrid pada Pembelajaran Praktikum Kimia Dasar dalam Meningkatkan Keterampilan Proses Sains Mahasiswa
Authors: Pane Eva Pratiwi , Simangunsong Anita Debora Br , Sinaga Christa Voni Roulina
Published: October 2023

Pendidik perlu melakukan inovasi dalam pembelajaran dengan memanfaatkan salah satu media pembelajaran berbasis teknologi dengan menggunakan model pembelajaran yang tepat agar proses pembelajaran menjadi efektif dan bermakna. Tujuan dari penelitian ini yaitu untuk mengembangkan media pembelajaran flipbook model hybrid pada pembelajaran praktikum kimia dasar dalam meningkatkan keterampilan proses sains mahasiswa. Jenis penelitian ini adalah penelitian dan pengembangan (Research and Development) dengan model yang dikemukakan oleh Borg & Gall dengan menggunakan model 4D. Validasi ahli materi dan media digunakan untuk menilai kelayakan media. Kepraktisan dan efektivitas media di uji pada kelompok kecil. Instrumen penelitian terdiri dari lembar observasi, laporan praktikum dan angket. Data terdiri dari kualitatif dan kuantitatif dimana data dikumpulkan dengan menggunakan model concurrent atau bersamaan. Data kuantitatif diolah menjadi dalam persentase dan di interpretasikan menjadi tingkat kelayakan dan tingkat kepraktisan media. Efektivitas merupakan kemampuan media yang dikembangkan dalam mendukung peningkatan keterampilan proses sains mahasiswa. Data kualitatif menggambarkan keterampilan proses sains mahasiswa yang teramati selama mahasiswa mengikuti uji coba media. Berdasarkan hasil penelitian yang diperoleh dapat disimpulkan media pembelajaran flipbook dengan model hybrid pada pembelajaran praktikum kimia dasar yang telah dikembangkan ini sangat layak dan praktis untuk digunakan pada pembelajaran praktikum kimia dasar serta dapat digunakan untuk melatih keterampilan proses sains mahasiswa secara mandiri maupun secara terbimbing.
Pengembangan Aplikasi “DaDi Pinter” Sebagai Media Pembelajaran Berbasis Mobile Learning Pada Materi Fluida Dinamis
Authors: Pradigdo Lugas Haryo , Anggaryani Mita
Published: October 2023

Media pembelajaran memiliki peran yang sangat vital dalam proses pembelajaran. Media pembelajaran yang mengikuti pembelajaran saat ini adalah media berbasis teknologi. Pembelajaran dengan menggunakan teknologi memiliki keunggulan dapat memberikan kesempatan belajar kapanpun dan dimanapun. Penelitian ini bertujuan untuk menganalisis hasil validitas aplikasi DaDi Pinter sebagai media pembelajaran berbasis mobile learning untuk meningkatkan hasil belajar kognitif pada materi fluida dinamis. Penelitian ini menggunakan metode pengembangan ADDIE. Tiga tahap digunakan: analisis, desain, dan pengembangan. Tahap analisis dilakukan dengan menganalisis materi, kebutuhan, dan kebiasaan siswa. Tahap desain dilakukan dengan merancang tampilan dan konten aplikasi DaDi Pinter. Selanjutnya tahap pengembangan dilakukan dengan melakukan validasi dan revisi aplikasi DaDi Pinter berdasarkan masukan dan saran dari validator. Validitas aplikasi DaDi Pinter dinilai menggunakan skala Likert. Ahli media dan ahli materi menilai validitas aplikasi DaDi Pinter. Penilaian validasi media dilihat dari desain tampilan, operasi program, navigasi, dan kegunaan. Penilaian validasi materi terdiri dari aspek kualitas materi dan kemanfaatan materi. Teknik analisis data dilakukan dengan menghitung hasil validitas aplikasi DaDi Pinter dari 3 validator. Hasil penelitian menunjukkan bahwa validitas aplikasi DaDi Pinter pada media diperoleh persentase rata-rata sebesar 96% dengan kategori sangat valid. Hasil menunjukkan validitas aplikasi DaDi Pinter adalah 98%. Berdasarkan hasil validitas tersebut, aplikasi DaDi Pinter sangat valid dan dapat digunakan dalam pembelajaran.
ABSTRAK Indonesia salah satu negara yang rawan akan bencana alam seperti gempa bumi dan gunung api. Bencana-bencana alam tersebut bisa terjadi kapan saja dan dimana saja. Salah satu provinsi di Indonesia yang rawan akan letusan gunung api adalah Bali. Pen
Authors: Maharani Nia
Published: October 2023

ABSTRAKIndonesia salah satu negara yang rawan akan bencana alam seperti gempa bumi dan gunung api. Bencana-bencana alam tersebut bisa terjadi kapan saja dan dimana saja. Salah satu provinsi di Indonesia yang rawan akan letusan gunung api adalah Bali. Pengetahuan dasar yang cukup terkait gunung api dibutuhkan oleh seluruh masyarakat Bali terutama pada anak-anak tentang tindakan antisipasi terhadap letusan gunung api. Tujuannya untuk mengurangi resiko bahaya gunung api. Pada penelitian ini peneliti mengambil lokasi penelitian pada panti asuhan Dharma Jati I Klungkung Bali. Sejumlah pertanyaan dalam bentuk kuisioner diberikan kepada anak-anak penghuni panti asuhan tersebut. Berdasarkan observasi yang telah dilakukan sebelumnya belum adanya penyuluhan tentang bencana gunung api pada panti asuhan tersebut. Sarana dan prasarana juga masih terbatas hanya berupa televisi sehingga anak-anak sedikit mendapatkan informasi bahkan ada yang belum pernah mendapatkan informasi sama sekali. Kuisioner berisi 10 pertanyaan diberikan kepada anak-anak panti asuhan berkaitan dengan pengetahuan dasar gunung api seperti pengertian, penyebab, ciri dan dampak letusan gunung api dengan hasil masih kurangnya pengetahuan anak-anak panti asuhan tentang gunung api itu sendiri.

Kata kunci: anak-anak panti asuhan, gunung api, pengetahuan
Diagnóstico e tratamento da mialgia epidêmica: Uma revisão da literatura nos últimos 10 anos
Authors: Menezes Caroline Nascimento , Aragão Matheus Todt
Published: October 2023

A mialgia epidêmica, também conhecida como miosite epidêmica, é uma condição caracterizada por dor muscular intensa e generalizada. Essa condição pode estar associada a diversos vírus, como influenza, Coxsackie, Epstein-Barr, herpes simplex, parainfluenza, adenovírus, entre outros. A mialgia pode ocorrer em casos de pleurodinia epidêmica, conhecida como síndrome de Bornholm, causada principalmente por enterovírus. A síndrome de Bornholm afeta a musculatura intercostal, resultando em dor torácica intensa e intermitente, febre, dor de garganta, cefaleia e mialgia. Ademais, a mialgia pode ocorrer em casos de infecção pelo Parechovirus (HPeV), um vírus de RNA da família Picornaviridae. O HPeV3, em particular, tem sido associado a infecções em crianças antes dos 5 anos de idade, causando sintomas de mialgia e fraqueza muscular, afetando principalmente os músculos proximais das pernas e braços. Este artigo tem como objetivo estudar os aspectos epidemiológicos e clínicos da mialgia epidêmica nos últimos 10 anos. Os objetivos específicos incluem analisar a epidemiologia dos casos, identificar os agentes etiológicos relacionados, descrever a apresentação clínica e discutir abordagens diagnósticas e terapêuticas. Dessa forma, o método utilizado foi o de uma revisão sistemática de literatura, cujo objetivo foi sintetizar, de forma metódica e imparcial, as evidências disponíveis acerca da mialgia epidêmica e seu respectivo diagnóstico e tratamento. Em sede de resultados, foi possível identificar que o diagnóstico é realizado por testes laboratoriais, como detecção de anticorpos e sequenciamento do vírus, podendo essa afetar tanto crianças quanto adultos, com sintomas graves e persistentes, assim, o tratamento envolve o uso de analgésicos e anti-inflamatórios, buscando apenas minimizar os sintomas.
Avaliação do nível de atividade física, ansiedade e sintomas depressivos de estudantes universitários do curso de Educação Física durante o isolamento social
Authors: Mamede Fabiola Antonieta da Costa , Alves Rafael Ribeiro , Ferreira Júnior João Batista , Romero Alexandre , Lira Claudio André Barbosa de , Vieira Carlos Alexandre
Published: October 2023

O objetivo do presente estudo, feito por meio de uma pesquisa social de natureza quantitativa, foi avaliar o nível de atividade física, ansiedade e sintomas depressivos em estudantes universitários do curso de Educação Física, da Universidade Federal de Goiás, durante o período de isolamento social causado pela pandemia da COVID-19, bem como, analisar os fatores associados com os desfechos analisados. Participaram do estudo 41 universitários de ambos os sexos (23,9 ± 4,7 anos; 169,9 ± 9,7 cm; 71 ± 16,1 kg). Foram coletadas as informações sobre o nível de atividade física (AF), ansiedade-estado (AE), ansiedade-traço (AT) e sintomas de depressão (SD). A maior parte dos universitários foi classificada como ativos (36,6%) e muito ativos (29,3%) (205,7 ± 331,27 MET diário; de 1440,0 ± 2318 MET semanal). Aproximadamente, 53,7% e 56,1% dos indivíduos apresentaram escores elevados para AE e AT, respectivamente. Por volta de 39% dos indivíduos apresentaram SD moderado ou grave. Foram identificadas associações entre AE e SD (r= 0,84; p<0,001), AT e SD (r= 0,87; p<0,001), e entre AE e AT (r=0,91; p<0,05). Todavia, não foram encontradas associações entre o nível de atividade física e as demais variáveis. Dessa forma, apesar de 65,9% da amostra ter sido classificada com ativo e muito ativo, os níveis de AE, AT e SD apresentaram escores elevados. É possível que esses achados apresentem relação com a pandemia de COVID-19 e as medidas de isolamento social.
Fatores de risco e prognóstico em neoplasia trofoblástica gestacional: Uma revisão
Authors: Carvalho Alex Roriz de Menezes Lustosa , Serra Ivi Gonçalves Soares Santos
Published: October 2023

Os fatores de risco e prognóstico desempenham um papel crucial na avaliação e tratamento da neoplasia trofoblástica gestacional (NTG), uma condição rara e potencialmente grave que afeta o tecido placentário durante a gestação. Destaca-se que compreender os fatores de risco ajuda os profissionais de saúde a identificar mulheres grávidas que podem estar em maior risco de desenvolver NTG. Isso permite um diagnóstico mais precoce e, portanto, um tratamento mais eficaz. Nesse cenário, objetivou-se nesse estudo realizar uma revisão abrangente da literatura científica disponível para identificar os principais fatores de risco associados à NTG e avaliar os fatores prognósticos que influenciam o desfecho clínico e a progressão da doença. A presente pesquisa trata-se de uma revisão sistemática, destaca-se que esta é uma abordagem rigorosa e estruturada para a síntese de evidências científicas disponíveis sobre um determinado tópico de pesquisa. Após a análise, a busca resultou em dez artigos científicos que formaram a base da pesquisa. As informações revelam que a idade gestacional mais avançada, experiência anterior com mola hidatiforme, histórico de ter tido filhos e morar longe de centros de saúde foram identificados como fatores que aumentam consideravelmente o risco. A partir desta análise dos fatores que influenciam a probabilidade de desenvolver neoplasia trofoblástica gestacional e das variáveis que impactam o seu curso clínico, podemos inferir que ter um conhecimento aprofundado desses componentes desempenha um papel essencial na avaliação e no tratamento eficaz dessa condição médica.
PENINGKATAN KAPASITAS KADER DESA DALAM MENCEGAH DAN MENGENDALIKAN DIABETES MELITUS MELALUI PROMEDIA (PROGRAM EDUKASI MANAJEMEN DIABETES MELITUS)
Authors: Iin Patimah Iin Patimah , Tantri Puspita Tantri Puspita , Rudy Alfiyansah Rudy Alfiyansah , Andhika Lungguh Perceka Andhika Lungguh Perceka
Published: October 2023

Health cadres trained in Diabetes Mellitus (DM) are needed to help improve regional health. Training and educational actions to prevent and control Diabetes Mellitus in the form of PROMEDIA (Diabetes Mellitus Management Education Program) can be useful activities to improve the level of public health at large. This activity was carried out for 2 days in the Hall of the Tarogong Community Health Center with the presence of 30 Health cadres. The results of measuring calorie need showed that, the Temporary Blood Sugar (GDS) of the cadres present ranged from 88 mg/dl -316 mg/dl (mean= 134 mg/dl), calorie needs ranged from 1236 cal – 2415 cal (mean= 1524 cal). The results of health education show that 76% of cadres experienced an increase in knowledge after being given education. This Promedia activity showed benefits especially for cadres, including increasing knowledge about diabetes mellitus management, skills in checking blood sugar levels, calculating daily calorie needs and daily follow-up mechanisms
Real-World Evidence of Biosimilar Utilisation and Pharmacoeconomics in People Living with Breast or Lung Cancer
Authors: Moir Hannah
Published: October 2023

As the medical community continues to explore and harness the potential of biosimilars, it is imperative to accumulate robust real-world evidence (RWE) to guide informed decision-making, and enhance patient outcomes in cancer treatment. This article reviews the current understanding and utilisation of biosimilars in the treatment of breast and lung cancers by reviewing existing RWE. A literature search of PubMed, MEDLINE, and Scopus was performed to analyse observational studies pertaining to the adoption of biosimilars in people living with breast or lung cancer, with publications considered since 2019. The review summarises the current RWE relating to biosimilar use for its approved indications across breast and lung cancer. Despite the scarcity of evidence addressing the cost-effectiveness of biosimilars in breast and lung cancer treatment, biosimilars may offer a dual benefit by enhancing patient outcomes, while ensuring cost-effectiveness, thereby increasing access to oncology therapies globally. The increased access to biosimilars within community oncology practices, hospitals, and national healthcare systems, promises substantial cost savings. This review highlights the evolving landscape of biosimilar utilisation in oncology, revealing their potential as a more affordable and inclusive approach to cancer care, while also indicating areas for further research.
Self-Reliance Therapy: Reflections and a New Model
Authors: Nath Amaresh , Bhuvan Harish
Published: October 2023

Background: Using the learnings and reflections from their professional and personal journeys, the authors believe that every “Neurosisoriented” mental health concern has four root causes: self-love (a lack of it), fear, grief, and aim (a lack of it). Using this as the premise, the authors have developed a new therapeutic modality that incorporates 12 primary universal formulas that they have conceptualized.

Methods: This novel therapeutic model was implemented on 5 pilot batches, and was delivered to a total of 50 clients. The clients were from the upper-middle class section of Indian society, and their ages ranged from 21 to 58.

Outcomes: Every participant had their own unique breakthrough moments over the three days of the implementation process. Further qualitative and quantitative research is needed before this new modality can be claimed as beneficial.

Interpretation: This modality can be used in both group as well as individual settings, and even implemented in a group, the structure of this modality enables each participant to have a personalized experience.
Special Issue on Archaeology
Authors: Trygub Oleksandr
Published: October 2023

On the preparation of a special issue on archeology in the conditions of the Russian-Ukrainian war
New Settlement of Holercani-Hansca Cultural Horizon in Republic of Moldova
Authors: Agulnikov Serghei
Published: October 2023

As a result of field surveys of the last years, the new site of Holercani-Hansca cultural group – Andreevca-I settlement has been found. The purpose of this research paper is the characteristics of the mentioned site and the interim results of its study.

Results. Andreevca-I settlement is located in Orhei raion of the Republic of Moldova, at the lands of Chiperceni Community. The site is located 0.38 km northeast of the village of Andreevca and 0.28 km northwest of the pond of the village of Andreevca; on the left bank of the stream Vorotet. The settlement is located on a smooth slope. The land area of the settlement along the line North-West-South-East is 100x200 m. Fragments of ceramics, bones of animals, pieces of burnt clay, and different stones, some of them with traces of processing, were found on the plowed surface. The settlement is multilayered. The ceramics of the Late Bronze Age prevail in the materials of the settlement. It is associated with Holercani-Hansca cultural group (12th – 10th century BCE), interim between the cultures of the early Hallstatt, and the Late Bronze Age.

According to O.G. Levitskiy, Holercani-Hansca group fills the gap between the cultural formations of Pre-Babadag and Tămăoani type and Balta group of sites of the Late Bronze Age. In addition, Hallstatt horizon with prevailing incised ceramics, which can be conventionally called Tămăoani-Holercani-Balta, is distinguished. Chronological framework of this horizon according to analogues of Balta group and Tămăoani can be the end of the 12th – 10th century BCE. The closest analogues to this cultural formation could be the cultures of the Lower Danube region – Sihleanu, Tămăoani, Pre-Babadag, Babadag-I, and early Belozerka culture sites, including Balta group of the Late Bronze Age. The role of Chisinau-Corlateni type sites, of which Holercani-Hansca group had got a number of material borrowings while forming its cultural entity, is doubtless.
Enhancing antioxidant delivery through 3D printing: a pathway to advanced therapeutic strategies
Authors: Alogla Ageel
Published: October 2023

The rapid advancement of 3D printing has transformed industries, including medicine and pharmaceuticals. Integrating antioxidants into 3D-printed structures offers promising therapeutic strategies for enhanced antioxidant delivery. This review explores the synergistic relationship between 3D printing and antioxidants, focusing on the design and fabrication of antioxidant-loaded constructs. Incorporating antioxidants into 3D-printed matrices enables controlled release and localized delivery, improving efficacy while minimizing side effects. Customization of physical and chemical properties allows tailoring of antioxidant release kinetics, distribution, and degradation profiles. Encapsulation techniques such as direct mixing, coating, and encapsulation are discussed. Material selection, printing parameters, and post-processing methods significantly influence antioxidant release kinetics and stability. Applications include wound healing, tissue regeneration, drug delivery, and personalized medicine. This comprehensive review aims to provide insights into 3D printing-assisted antioxidant delivery systems, facilitating advancements in medicine and improved patient outcomes for oxidative stress-related disorders.
Accurate diagnosis of bronchopulmonary Talaromyces marneffei infection in an anti-IFN-γ autoantibodies positive patient assisted by endobronchial ultrasound-guided TBNA and mNGS: a case report
Authors: Chen Guirong , Ma Nan , Zhu Donglan , Zhou Huaihai , Liang Qiumei , Meng Jianfeng , Shen Yin , Liu Hang , Liu Liu , He Zhiyi , Qin Zhiqiang
Published: October 2023

Rationale: T. marneffei is opportunistic and dimorphic fungus, which can cause systemic mycosis in human beings. It’s being difficult to obtain histopathological or microbiological evidence in T. marneffei infection. We reported a rare non-HIV case of T. marneffei infection of bronchopulmonary and mediastinal lymph nodes which was diagnosed by EBUS-TBNA combined with mNGS. The high titer of anti-IFN-γ autoantibodies in serum was probably the cause of T. marneffei infection,which has yet to be fully known. Patient concerns: A 56-year-old Chinese man presented with a 5-month history of intermittent low or high fever and dry cough, followed by fatigue, night sweating, and chest pain when coughing. A large hilar lesion in the left lung and multiple mediastinal lymph node enlargements were found on his chest CT scan. Diagnoses: The patient received EBUS-TBNA of hilar tissue and lymph node biopsy for mNGS at the second Ultrasonic bronchoscopy. No fungal hyphae or spores were found in the histopathology. There were high sequencing reads of T. marneffei in samples of lymph node fluid and bronchogenesis tissue detected by mNGS. His plasma anti-IFN-γ autoantibodies level was positive with a high titer at 1:2500↑. Intervention: The patient went through atrial fibrillation at the first dose of amphotericin B liposomes and treated with voriconazole later. Outcomes: His fever, cough and dyspnea quickly disappeared since the fourth day of treatment. After six months, there was not any focus in his chest CT scans. But his plasma anti-IFN-γ autoantibodies remained unchanged. Lessons: Complementing the traditional laboratory and bronchoscopy, mNGS combined with EBUS-TBNA facilitate rapid and precise diagnosis of bronchopulmonary mediastinal lymph nodes T. marneffei infection. Clinicians should be aware of anti-INF-γ autoantibodies in opportunistic infections of non-HIV patients.
Functional behaviour of flocs explained by observed 3D structure and porosity
Authors: Lawrence T. J. , Carr S. J. , Manning A. J. , Wheatland J. A. T. , Bushby A. J. , Spencer K. L.
Published: October 2023

Clay-rich flocculated suspended sediments are an important constituent of estuarine and coastal systems globally. They are responsible for the host, movement and deposition of a variety of pollutants, contaminants and sediment itself. Accurate modelling of the movement of these sediments is crucial for a number of industries including fisheries, aquaculture, shipping and waste management. This requires an accurate and reliable measurements of the physical properties of flocs and their behaviour. Porosity is a key element in floc structures, and this research provides updated 3D quantified porosity and pore space morphological data in relation to influences on floc settling behaviour. We report the questionable relationship between floc size and settling velocity, and explore alternative influences such as floc composition, porosity and pore morphology. These outcomes suggest that a shift in focus from floc size to a combination of factors is necessitated to understand the complex movement behaviour of flocculated suspended sediments.
The impact of external plant carbon sources on nitrogen removal and microbial community structure in vertical flow constructed wetlands
Authors: Lin Yan , Lu Xingshun , Zhao Manping , Ding Xiaoyu , Lv Hang , Wang Lixin , Wu Linhui
Published: October 2023

The present study was developed to explore nitrogen removal performance and associated microbial mechanisms of action in vertical flow constructed wetlands (VFCWs) when using external carbon sources. These analyses ultimately revealed that alkali-soaked Phragmites australis (P. australis) could serve as an effective plant carbon source, exhibiting the lower levels of total nitrogen (TN) release and the highest chemical oxygen demand (COD) of all tested carbon sources. Nitrogen removal efficiency improved following the addition of plant carbon sources, and under carbon/nitrogen (C/N) rations of 2, 4, 5, and 7, the VFCW system was able to remove 43.69%–75.76% TN, with the highest removal rate being observed at a C/N of 5. The abundance of denitrifying microorganisms such as Thiobaillus and Halomonas were also more enriched in VFCW1 than VFCW0, with stronger correlations in the microbial network community. A qPCR approach was used to analyze functional genes involved in denitrification, revealing that the addition of plant carbon sources was associated with increases in total gene abundance and the abundance of the denitrifying gene nirS, whereas no corresponding increase in amoA or nxrA abundance was observed. Higher total gene, amoA, and nxrA abundance were observed in the upper levels of these VFCW systems as compared to the lower layers, whereas nirS exhibited the opposite abundance pattern. Overall, these findings suggested that short-range denitrification is likely to be the primary denitrification process active in this VFCW system.
Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells
Authors: Tassi Elena , Bergamini Alice , Wignall Jessica , Sant’Angelo Miriam , Brunetto Emanuela , Balestrieri Chiara , Redegalli Miriam , Potenza Alessia , Abbati Danilo , Manfredi Francesco , Cangi Maria Giulia , Magliacane Gilda , Scalisi Fabiola , Ruggiero Eliana , Maffia Maria Chiara , Trippitelli Federica , Rabaiotti Emanuela , Cioffi Raffaella , Bocciolone Luca , Candotti Giorgio , Candiani Massimo , Taccagni Gianluca , Schultes Birgit , Doglioni Claudio , Mangili Giorgia , Bonini Chiara
Published: October 2023

Introduction

Despite predicted efficacy, immunotherapy in epithelial ovarian cancer (EOC) has limited clinical benefit and the prognosis of patients remains poor. There is thus a strong need for better identifying local immune dynamics and immune-suppressive pathways limiting T-cell mediated anti-tumor immunity.

Methods

In this observational study we analyzed by immunohistochemistry, gene expression profiling and flow cytometry the antigenic landscape and immune composition of 48 EOC specimens, with a focus on tumor-infiltrating lymphocytes (TILs).

Results

Activated T cells showing features of partial exhaustion with a CD137+CD39+PD-1+TIM-3+CD45RA-CD62L-CD95+ surface profile were exclusively present in EOC specimens but not in corresponding peripheral blood or ascitic fluid, indicating that the tumor microenvironment might sustain this peculiar phenotype. Interestingly, while neoplastic cells expressed several tumor-associated antigens possibly able to stimulate tumor-specific TILs, macrophages provided both co-stimulatory and inhibitory signals and were more abundant in TILs-enriched specimens harboring the CD137+CD39+PD-1+TIM-3+CD45RA-CD62L-CD95+ signature.

Conclusion

These data demonstrate that EOC is enriched in CD137+CD39+PD-1+TIM-3+CD45RA-CD62L-CD95+ T lymphocytes, a phenotype possibly modulated by antigen recognition on neoplastic cells and by a combination of inhibitory and co-stimulatory signals largely provided by infiltrating myeloid cells. Furthermore, we have identified immunosuppressive pathways potentially hampering local immunity which might be targeted by immunotherapeutic approaches.