bluuebunny/crossref_metadata_2025 huggingface dataset:
Mycobacterium tuberculosis Mce3R TetR-like Repressor Forms an Asymmetric Four-Helix Bundle and Binds a Non-Palindrome Sequence
Authors: Panagoda Navanjalee T. , Balázsi Gábor , Sampson Nicole S.
Published: September 2024

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a major global health concern. TetR family repressors (TFRs) are important for Mtb's adaptation to the human host environment. Our study focuses on one notable Mtb repressor, Mce3R, composed of an unusual double TFR motif. Mce3R-regulated genes encode enzymes implicated in cholesterol metabolism, resistance against reactive oxygen species, lipid transport activities important for Mtb survival and persistence in the host, and for the cellular activity of a 6-azasteroid derivative. Here, we present the structure of Mce3R bound to its DNA operator, unveiling a unique asymmetric assembly previously unreported. We obtained a candidate DNA binding motif through MEME motif analysis, comparing intergenic regions of mce3R orthologues and identifying non-palindromic regions conserved between orthologues. Using an electrophoretic mobility shift assay (EMSA), we confirmed that Mce3R binds to a 123 bp sequence that includes the predicted motif. Using scrambled DNA and DNA oligonucleotides of varying lengths with sequences from the upstream region of the yrbE3A (mce3) operon, we elucidated the operator region to be composed of two Mce3R binding sites, each a 25 bp asymmetric sequence separated by 53 bp. Mce3R binds with higher affinity to the downstream site with a Kd of 2.4 ± 0.7 nM. The cryo-EM structure of Mce3R bound to the 123 bp sequence was refined to a resolution of 2.51 Å. Each Mce3R monomer comprises 21 α-helices (α1-α21) folded into an asymmetric TFR-like structure with a core asymmetric four-helix bundle. This complex has two non-identical HTH motifs and a single ligand-binding domain. The two non-identical HTHs from each TFR bind within the high-affinity, non-palindromic operator motif, with Arg53 and Lys262 inserted into the major groove. Site-directed mutagenesis of Arg53 to alanine abrogated DNA binding, validating the Mce3R/DNA structure obtained. Among 811,645 particles, 63% were Mce3R homodimer bound to two duplex oligonucleotides. Mce3R homodimerizes primarily through α15, and each monomer binds to an identical site in the DNA duplex oligonucleotide.
La ejecución de las sentencias de condena por parte del Estado peruano: propuesta para la implementación de un nuevo procedimiento
Authors: Fox Velarde Melanie Alessandra
Published: September 2024

El presente artículo aborda los diversos factores procedimentales y de asignación de funciones que, establecidos en el artículo 46 del Texto Único Ordenado de la Ley 27584, contribuyen al problema del incumplimiento de las sentencias de condena por parte del Estado peruano. La autora propone que la creación de un nuevo procedimiento podría brindar efectividad y celeridad a la ejecución de las obligaciones de pago impuestas al Estado en este tipo de sentencias. Esta propuesta busca la optimización en el procedimiento de pago de las obligaciones pecuniarias del Estado al particular-vencedor. Con ella se lograría garantizar el cumplimiento de este tipo de obligaciones ordenadas por mandato judicial en los casos contencioso-administrativos en el contexto peruano.
Early detection and screening for cervical cancer
Authors: Kamala J. , Jayaseelan MD Dr.
Published: September 2024

None
Knowledge of antenatal mothers regarding hyperthyroidism in pregnancy
Authors: Elsa Abraham Linu
Published: September 2024

None
Zika Virus: New Public Health Threat
Authors: Punarva M.H. Mrs.
Published: September 2024

None
Effect of guideline on positioning of neonates in the nicu
Authors: Soniya PS , . Chandrakala , Sheeja PP
Published: September 2024

None
Knowledge regarding shaken baby syndrome among mothers of infants
Authors: MS Radha , Subhashini Lavanya , GK Baby
Published: September 2024

None
Prevalence pattern of alcoholism among general male population at selected village, Bangalore
Authors: V.T Lakshmamma. , Kalavati S. Elangovan Dr.
Published: September 2024

None
Reflections on the care of a patient with pallative care needs.
Authors: Mathew Shiny
Published: September 2024

None
Wellness- Changing lives
Authors: Manjuri. AE Dr.
Published: September 2024

None
Effectiveness of structured teaching and demonstration programme on knowledge and performances of BLS among care givers of MI patients
Authors: Vijayalakshmi G. , George Deepu
Published: September 2024

None
Implementasi Layanan Profilaksis Pra Pajanan (PrEP) Oral (Studi Kualitatif 2 Puskesmas di Kota Semarang)
Authors: Isnaeni Rizka Nur , Kusumawati Aditya , Handayani Novia
Published: September 2024

Pemberlakuan uji coba program Pre-Exposure Prophylaxis (PrEP) sebagai program pencegahan HIV di Kota Semarang belum berjalan optimal. Petugas kesehatan yang memiliki peran penting sebagai pelaksana program masih mengalami berbagai kendala, baik hambatan secara teknis maupun hambatan dalam pencatatan dan pelaporan yang cukup rumit. Program yang sudah berjalan hampir 3 tahun ini sangat penting untuk dilakukan kajian yang lebih mendalam, khususnya pada petugas kesehatan yang berperan langsung dalam memberikan layanan PrEP. Pengumpulan data secara deskriptif kualitatif yang dilakukan dengan wawancara mendalam. Subjek penelitian terdiri dari informan sembilan utama dan informan empat triangulasi dengan metode purposive sampling . Validitas data dilakukan dengan triangulasi sumber data. Reliabilitas data dilakukan dengan audit data dan analisis data menggunakan metode analisis isi . Hasil penelitian menunjukkan bahwa pelaksanaan program PrEP oleh petugas kesehatan belum sesuai dengan pedoman tata laksana yang diterbitkan oleh Kementerian Kesehatan Republik Indonesia tahun 2023. Sebagian besar petugas kesehatan memiliki tingkat pengetahuan yang rendah terkait program PrEP dan berpersepsi bahwa program PrEP mendukung LGBT dan bebas seks. Akibatnya, muncul konflik intrapersonal karena dianggap bertentangan dengan pola pemikiran dan hati nuraninya. Kesimpulan penelitian ini adalah tingkat pengetahuan yang rendah pada sebagian besar pelaksana program PrEP memberikan pengaruh yang cukup besar pada keberjalanan program PrEP. Oleh karena itu, perlu adanya pelatihan terkait program PrEP secara berkala yang lebih komprehensif.
Antibacterial synergistic effect of sea cucumber extract and kelulut honey
combination
Authors: Nizam N.N.N.H. , Kamarudin K.R. , Rehan A.M.
Published: September 2024

Natural products remain one of the major sources of new drug molecules today. The
combination of sea cucumber extract with stingless bee honey holds great potential for
health supplement. However, the specific results of the combination have yet to be
determined. In this study, the antibacterial activity of kelulut honey and Phyllophorus
spiculata sea cucumber extract samples individually and in combination were assessed
with disk-diffusion assays and broth dilution method. Most of the samples exhibit small or
absence of inhibitory activity using disk-diffusion assay method. Only kelulut honey
sample with 100% concentration has a positive antagonism effect against Escherichia coli
and Staphylococcus epidermidis. For the broth dilution method, Gram-positive bacteria
were found to be more susceptible as compared to Gram-negative bacteria species, with
lower minimum inhibitory concentration (MIC) value of kelulut honey, sea cucumber or
combination sample. The growth of gram-positive S. epidermidis is inhibited by sea
cucumber extract at MIC value of 0.031 mg/mL, kelulut honey at MIC value of 0.063 mg/
mL and combination sample at MIC value of 0.063 mg/mL, all of which are of lower MIC
value as compared to E. coli inhibition. The absorbance at optical density (OD) 600nm
wavelength was also measured to monitor the growth of bacteria in solution. From the
results, broth dilution proves to be a more effective method to assess the antibacterial
activity in the combination samples. Two combinations showed the best antibacterial
synergy (OD600 value of 0.000) against both Gram-positive and Gram-negative bacteria,
which were (1) ½ sea cucumber: ½ kelulut honey combination and (2) ¾ sea cucumber: ¼
kelulut honey combination. This preliminary evidence on their antibacterial synergistic
activities is promising and shows possible commercialization potential.
Analysis of the Current Situation of Cost Management and Control of Highway Construction Projects
Authors: Liu Pei
Published: September 2024

The highway engineering process is complex, coupled with a relatively long construction period, hence requires increased coordination between participating units to prevent economic disputes and efficiency losses. The main body of the construction project needs to strengthen the management and control of funds. In this regard, this paper analyzes the importance of cost management in highway projects by clarifying and analyzing the current cost management status quo problems and causes. The highway engineering cost control strategy and implementation methods are summarized to provide references for improving the quality of highway engineering.
Anaesthesia for Foetal Interventions
Authors: Kota Karanth Sowmyashree , M. Tran Kha
Published: September 2024

This tutorial provides comprehensive insights on the anesthetic management of foetal interventions, including minimally invasive, open mid-gestation, and EXIT procedures. It covers indications, pertinent maternal and fetal physiology, anaesthetic techniques, foetal resuscitation, postoperative care, and potential complications.
INTERNAL MARKETING AS AN ENTRANCE TO ACHIEVING SUSTAINABLE HUMAN DEVELOPMENT/ APPLIED RESEARCH IN AL-FURAT STATE COMPANY FOR CHEMICAL INDUSTRIES
Authors:   1Assistant Professor PhD. Market Research and Consumer Protection Center, University of Baghdad. Baghdad. Iraq. wesalab@mracpc.uobaghdad.edu.iq, Husain1 Wisal Abdullah , Al-Heali2 Alaa Nabeel ,   2Lecturer, Market Research and Consumer Protection Center, University of Baghdad. Baghdad. Iraq. alaanabeelal@mracpc.uobaghdad.edu.iq, Jabbar3 Safaa Nayyef Abdul- ,   3Al-Furat General Company for Chemical Industries and Pesticide, Ministry of Industry and Minerals. safaaengineer2024@gmail.com
Published: September 2024

The research was conducted at Al-Furat General Chemical Industries Company (one of the formations of the Ministry of Industry and Minerals) with the aim of analyzing the relationship between internal marketing variables (employee recruitment, training, incentives, management support, clarity of marketing information) and the possibility of achieving the principles of sustainable human development (empowerment, social justice and equity)., cooperation, sustainability, safety and job stability) through an opinion poll that was distributed to a random sample of forty employees in that company. We adopted the electronic questionnaire as a tool for collecting data from that sample. The data we obtained was analyzed using percentages, trying to diagnose points. Weakness in internal marketing indicators, and this was evident from the results of the incentive incentives index and weak marketing information, as their percentages ranged from average to below that, while some of the indicators of management support and training courses for employees recorded a relatively high approval rate. Accordingly, we recommend the need to direct the attention of the company's senior management to the indicators of incentives and clarity of marketing information, since their results were relatively lower than the rest of the indicators, knowing that these indicators are directly related or considered an important input to achieving the principles of sustainable human development such as cooperation, empowerment, safety, stability, and fairness.
Analysis of the course and outcomes of COVID-19 at different stages of the pandemic in hemodialysis patients
Authors: Frolova N. F. , Kim I. G. , Chervinko V. I. , Volodina E. V. , Zubkin M. L.
Published: September 2024

The purpose of this study was a comparative analysis of the characteristics of the course and outcomes of COVID-19 in HD patients at different stages of the pandemic, focusing on the of the use of immunomodulatory therapy.

Materials and methods. The retrospective study included 897 HD patients with COVID-19 (mean age 60.7 years, M 58.5%) who were hospitalized at Moscow City Hospital № 52. Group 1 (n=720) consisted of patients infected between the end of March 2020 and April 2021, group 2 (n=177) included patients hospitalized in May-December 2021. Each of group was divided into 2 subgroups based on treatment approaches. Subgroup 1a (n=231) included patients of the initial period of the pandemic who did not receive adequate immunomodulatory therapy, while Subgroup 1b (n=489) included patients of the late stage, were treated with IL-6 receptor blockers and corticosteroids. In group 2, 108 patients in Subgroup 2a received similar therapy, while 69 patients in Subgroup 2b were treated with neutralizing monoclonal antibodies in the early stages of the disease.

Results. Mortality rates in Group 1 and Group 2 was 20.1% and 14.7%, respectively (p<0.09). The incidence of unfavorable outcome was highest in Subgroup 1a and lowest in Subgroup 2b (31.2% vs 5.8%, p<0.01). Mortality in Subgroups 1b and 2a was comparable (14.9% and 20.4%), despite more severe initial lung damage according to CT data in Subgroup 2a. In these patients, immunomodulators was more frequently combined with therapeutic plasma exchange (TPE). Independent risk factors for an unfavorable outcome were the progression of pulmonary pathology, with the transformation of stages CT 1-2 to CT 3-4, and a high comorbidity index.

Conclusions. The use of immunomodulatory drugs imprtoved the effectiveness of COVID-19 treatment in patients with CKD5D. In severe cases, the most favorable outcomes were achieved with a combination of immunobiological drugs, corticosteroids, and TPE. An even more significant reduction in mortality was observed following the introduction of neutralizing monoclonal antibodies into clinical practice. Independent predictors of unfavorable outcome of COVID-19 in HD patients were a high comorbidity index and the progression of CT 1-2 into CT 3-4.
IDENTITY AND INFINITY: ALTERNATE MODES OF SCRIBING THE SELF: A COMPARISON OF MARIO VARGAS LLOSA’S AUNT JULIA AND THE SCRIPTWRITER AND YANN MARTEL’S LIFE OF PI
Authors: R Govind
Published: September 2024

An active engagement with the notion of the ‘self’ in modes of confrontation, contestation and conjuration has been an important tropological concern of fictional narratives, especially of an autobiographical intent and tone. Any coherent and significant concept of the ‘self’ entails a conglomeration of conscious and subconscious indices of subjectivities, intellectual sensibility, emotional drives and epistemological orientations, all of which are ideally conducive to artistic or material creativity. And, in life as well as in literature, it inevitably determines the ways and the extent to which the individual is capable of transcending the ‘personal’ to connect with the ‘other’ in varying degrees of empathetic identification. Literature is a terrain where one can encounter, on the one hand, protagonists who cross the confines of their self and feel one with the whole cosmos, and on the other, those who fail miserably in transcending the anxieties and fears of the personal, and recede into self-imposed reticence and insularity. The former is usually seen undertaking a self-chosen or imposed journey in which their inner psychic resources are unearthed and are ultimately traced to the vast eternity of cosmic energies. The latter is representative of the tragic consequences of the ruthless encroachment of normative social forces upon the personal space and the resultant subjugation of the individual self. There is also an in-between category of individuals who can strike a fine balance between their self and the social mores, through an ironic process of competitive negotiation. They consolidate their selves through the calibrated transgressions they perform upon the rules and rigours of social institutions and ethics, only to be re-inducted after a brief interregnum of ostracized animation.
“GOOD GIRLS AND BAD WOLVES?” - A READING OF BLURRED GENDER ROLES AND PARENTHOOD IN THE GRAPHIC NARRATIVES OF THE RED RIDING HOOD
Authors: Hilary Melissa , Angeline Anne
Published: September 2024

Though not so iconised and popularized as the other fairy tales characters such as Cinderella, Snow White, or Beauty and the Beast, Little Red Riding Hood has seen multifarious subversive revisions and adaptations in modern and postmodern art and literature. The role of motherhood is inextricable from the traditional narratives of the fairy tales; nonetheless, the recent retellings of the story in fiction, poetry, and notably in graphic narratives show a blurring of the gender archetypes. This paper analyzes the blurring of gender boundaries and parenthood in the graphic retelling of the popular fairy tale, Red Riding Hood, namely The Little Red Wolf by Amélie Fléchais, “Red” by Teloka And Pi, and Emily Carroll’s short comics “In Conclusion” and “His Face All Red”. These graphic narratives will be analyzed with the theoretical discourses of Julia Kristeva, Luce Irigaray, and Marina Warner.
Neural network classification of technological development projects in Russian companies: Perspectives of extreme project management
Authors: Mikhnenko Pavel
Published: September 2024

To achieve the goals of sustainable socio-economic development and ensure the technological sovereignty of the Russian Federation, it is critically important to choose effective methods of technological project management. The article develops a novel toolkit for neural network classification of technological development projects in Russian companies and justifies the use of extreme project management to such endeavors. The methodological framework resides in the concepts of project lifecycle management and data mining. The study employed the following research methods: textual analysis of project documentation using large language models, and intelligent project classification based on two-dimensional projection of multidimensional clusters using Orange Data Mining. The research draws upon regulatory documents in the field of Russia’s scientific and technological development and open databases on Russian companies’ projects. The work proposes a new neural network classification toolkit based on a large language model. We have found that most development projects related to critical and end-to-end technologies are characterized by low certainty of goals and solutions, which necessitates applying extreme approaches to manage them. The findings can be used by Russian companies for reasoning the choice of a project management model, as well as by experts when evaluating technological development projects.
Sparking leadership and perceived organizational support as predictors of cyberloafing
Authors: Yüncü Volkan , Ağtaş Emine
Published: September 2024

Alongside numerous benefits in business life (such as additional business opportunities, increased labour productivity), the Internet is responsible for adverse effects like cyberloafing in the workplace. Accessing the Internet for personal purposes during work hours is a prominent reason for counterproductive employee behaviour. The current theoretical background, however, is not sufficient to explain the causes of such behaviour. The article aims to identify the role of such factors as sparking leadership and perceived organizational support in preventing employees’ willingness to use their work time to engage in nonwork-related internet activities. To do so, five dimensions of cyberloafing are discussed: sharing, shopping, real-time updating, accessing online content, and gaming/gambling. Leadership theories, social exchange theory, and organizational support theory constitute the methodological basis of the research. The methods used are confirmatory factor analysis, and the PLS-SEM technique to reach a path model revealing the direct, indirect, and total relationships between the given dimensions. The data were collected from March to September 2023 through a face-to-face survey with 95 respondents from over 40 SMEs operating in Türkiye. The results revealed that perceived organizational support mediates the relationship between sparking leadership and sharing, shopping, and real-time updating dimensions of cyberloafing. The results point to the need for reconsidering organizational practices, values, and policies in a way that would foster employees’ well-being and happiness within the organization and mitigate their cyberloafing behaviour.
Por uma Educação Linguística Afroperspectivista: (re)pensando língua/linguagem em aulas de língua inglesa
Authors: Araújo João Paulo de Souza , Rigonato Lucas Gustavo do Nascimento
Published: September 2024

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O processo de escrita: alguns apontamentos sobre produção textual, revisão e reescrita nos anos inicias
Authors: Souza Tatiane Dark dos Santos , Berto Jane Cristina Beltramini
Published: September 2024

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Cartilha do participante enquanto gênero do discurso: um estudo sobre a compreensão responsiva do leitor
Authors: Souza Denilton André de , Silva Fátima Soares da
Published: September 2024

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Relações étnico-raciais e discurso racista no futebol: por uma proposta didática
Authors: Nascimento Vinícius Nicéas do , Cordeiro Maria Sirleidy
Published: September 2024

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CERTIFICAÇÃO DE IMÓVEIS RURAIS ENTRE AVANÇOS E DESAFIOS NO DESENVOLVIMENTO DA ESTRUTURA FUNDIÁRIA DO BRASIL
Authors: Neves Fredson de Jesus Pinto , Lopes Melissa Rodrigues , Duarte Mathias Ariel Chaves , Alencar Isabella Sales , Boaes Paulo Eduardo
Published: September 2024

A estrutura fundiária brasileira é um tema bem complexo, permeado por conflitos históricos e demanda medidas urgentes para promover um sistema justo e equitativo. A certificação de imóveis rurais processo instituído pela Lei 10.267 de 28 de agosto de 2001, completa 23 anos em 2024. Concebida para garantir a segurança jurídica das propriedades e fortalecer o desenvolvimento agrário, a iniciativa enfrenta desafios que persistem ao longo das duas décadas de sua implementação. A importância de iniciativas de profissionais capacitados para a orientação aos pequenos agricultores é um ponto muito importante a ser analisado visto que o estado do Maranhão por sua maioria é constituído pela agricultura familiar e por possuir um baixo IDH. Com isso, a pesquisa buscou, por meio de seu objetivo, analisar os avanços e desafios do sistema de gestão fundiária do Brasil. Onde foi utilizado uma abordagem de pesquisa exploratória, que visa compreender o assunto sem limitações prévias, permitindo uma visão mais completa do tema ao analisá-lo. O georreferenciamento tem trazido facilidade para a regularização do imóvel rural, sendo uma tecnologia eficaz e precisa, por outro lado o custo para ter essa ferramenta ainda é alta. A estrutura fundiária, segundo o IBGE, é um indicador da apropriação da natureza e da estratificação social no meio rural. E a regularização fundiária, por sua vez, garante o direito à propriedade e facilita o acesso a políticas públicas.

Palavras-chave: Jurídico, Geoprocessamento, Certificação.
DESAFIOS DO PROGRAMA NACIONAL DE ALIMENTAÇÃO ESCOLAR (PNAE) E DO PROGRAMA DE AQUISIÇÃO DE ALIMENTOS (PAA) NO FORTALECIMENTO DA AGRICULTURA FAMILIAR
Authors: Rodrigues Daniel dos Santos , Carvalho Eduarda de Sousa , Rodrigues Suellen Jhoyna de Oliveira , Pires João Henrique Coelho , Santos Valquiria Barros dos
Published: September 2024

As políticas públicas são essenciais para a agricultura familiar (AF) na institucionalização e desenvolvimento das atividades agrícolas, pela importância e o impacto da agricultura familiar na distribuição e abastecimento de alimentos para o mercado interno. O Programa Nacional de Alimentação Escolar (PNAE) e o Programa de Aquisição de Alimentos (PAA) são exemplos de programas de políticas públicas que buscam efetivar a associação da produção familiar e o consumo de alimentos em quantidade e qualidade que promovam a segurança alimentar. O presente trabalho tem como objetivo abordar os desafios do PNAE e do PAA como políticas públicas relevantes para o desenvolvimento da agricultura familiar e segurança alimentar brasileira. Neste trabalho, foi proposta a realização de uma revisão bibliográfica utilizando métodos qualitativos e descritivos de pesquisa sendo considerados trabalhos publicados nos últimos 15 anos. Os principais desafios descritos envolvem: i) questões estruturais quanto ao armazenamento dos alimentos e administrativas quanto ao número de gestores; ii) a oferta dependendo das adaptações nos cardápios, além do baixo percentual de compras e diversificação de alimentos; iii) dificuldades cadastrais referentes a processos burocráticos; e iv) questões orçamentárias pela redução nos recursos repassados. Com base na revisão de literatura, foi possível reforçar a importância dos programas PNAE e PAA no fortalecimento da agricultura familiar. Observou-se que esses programas de políticas públicas proporcionam uma alimentação digna e saudável aos beneficiários consumidores ao passo que gera um aumento na renda dos beneficiários fornecedores com a comercialização dos produtos agrícolas.

Palavras-chave: Produtos agrícolas, Comercialização, Aumento na renda, Políticas públicas, Segurança Alimentar e Nutricional.
DIAGNÓSTICO DO PERFIL TECNOLÓGICO E SOCIOECONÔMICO DO SISTEMA PRODUTIVO DA CAJUCULTURA NO MUNICÍPIO DE BARREIRINHAS, MARANHÃO
Authors: Lisboa Junior Edivaldo Rocha , Araujo José Ribamar Gusmão , Ottati Ana Maria Aquino dos Anjos , Martins Moisés Rodrigues , Lemos Raimunda Nonata Santos de , Caldas Anderson Santos
Published: September 2024

A produção de castanha de caju tem grande relevância para os Estados do Nordeste brasileiro, sendo um fator importante no desenvolvimento socioeconômico para o município de Barreirinhas, MA. A cajucultura é uma alternativa para os agricultores, pois apresenta capacidade adaptativa aos fatores climáticas como a seca, solos de baixa fertilidade natural, fonte de alimento nutritivo e por ser uma alternativa de renda no período de estiagem. A pesquisa objetivou realizar o diagnóstico do perfil tecnológico e socioeconômico do sistema produtivo do cajueiro Gigante no município de Barreirinhas, MA. O estudo foi realizado por meio da análise de dados a partir da aplicação de 36 questionários entre os cajucultores familiares, assentados em projetos de reforma agrária do Estado e do Governo Federal, escolhidos aleatoriamente. Foram avaliados os subíndices social, institucional e econômico e práticas de manejo adotados nos pomares. O sistema de produção do cajueiro Gigante pode ser caracterizado como extrativista, devido a sua forma de condução e manejo ao longo ciclo de produção. Poucas práticas agronômicas são adotadas pelo cajucultores, o que resulta em um baixo rendimento na produção de castanha e aproveitamento do pedúnculo. No aspecto econômico os indicadores de impacto da renda proveniente da produção de castanha, e satisfação com renda da produção de castanha foram consideradas ruins, enquanto a renda média do produtor e produção foram considerados bons. A insatisfação com a renda advinda da produção de castanha de caju está relacionada com a venda para atravessadores a baixo preço, desvalorizando a atividade.

Palavras-chaves: Cajueiro gigante, Castanha de caju, Desenvolvimento local, Agricultura familiar.
IMPACTO DOS CONFLITOS FUNDIÁRIOS NA AGRICULTURA FAMILIAR: COMO A DISPUTA POR TERRAS AFETA OS PEQUENOS AGRICULTORES E SUAS PRÁTICAS AGRÍCOLAS
Authors: Lima Gabriel Oliveira , Santos Marília Fernanda Muniz dos , Silva Antonya Vitória da Silva e , Pereira Adriane de Oliveira , Pinheiro Eduardo Mendonça
Published: September 2024

Este artigo aborda os impactos dos conflitos fundiários na agricultura familiar no Brasil, explorando suas causas, consequências e possíveis soluções. A agricultura familiar, responsável por grande parte da produção de alimentos frescos e pela geração de empregos no campo, enfrenta desafios significativos devido à concentração de terras e aos conflitos agrários. Os conflitos fundiários são intensificados pela disputa por terras historicamente marcada pela concentração fundiária e pela expansão do agronegócio. Isso resulta em insegurança jurídica para os agricultores familiares, limitações no acesso a recursos e no desenvolvimento de práticas agrícolas sustentáveis, e êxodo rural, afetando negativamente a segurança alimentar e a economia local. A análise revela um aumento alarmante da violência no campo, com registros de conflitos envolvendo milhões de pessoas e resultando em deslocamentos forçados e impactos psicológicos severos. Para mitigar esses problemas, são necessárias políticas públicas que priorizem a regularização fundiária, a proteção dos direitos dos agricultores familiares e o apoio financeiro e técnico para promover práticas agrícolas sustentáveis. A revisão bibliográfica evidencia a necessidade urgente de ações integradas para promover um desenvolvimento rural mais justo e equitativo no Brasil.

Palavras-chave: Luta Agrária, Latifúndios, Agricultura Familiar, Desenvolvimento Rural.
EVALUATION OF HUMAN RESOURCE MANAGEMENT IN PUBLIC DENTAL ORGANISATIONS
Authors: Dosberdiyeva Gulbanu
Published: September 2024

The article presents the results of the assessment of the performance of human resources services of dental organisations of state ownership. The subject of the study was the existing practice of human resource management services in dental organisations in several cities in the south of Kazakhstan (Almaty, Shymkent, Taraz). A scoring system was used as a research tool, and a qualitative study was conducted using a focus group that included human resource managers from dental organisations. Focus group questions included information on recruitment and selection strategies, adaptation of new staff and opportunities for staff development. As part of the assessment of the quality of human resources management, a quantitative and qualitative analysis of the composition of the workforce was carried out using indicators such as: staff turnover rate (doctors, nurses and non-medical staff), effectiveness of staff selection for interviews, employee satisfaction, implementation of human resources forecasts, preparation of a human resources reserve, existence of standardised operating procedures, existence of a corporate culture development programme. A sociological survey of 150 dentists and 120 nurses was conducted to assess satisfaction with working conditions and pay. A 36-item "Job Satisfaction Questionnaire" adapted to the objectives of the study was used. The normality of the distribution of the characteristic was tested using descriptive statistics, graphs and the Shapiro-Wilk statistical test (for small samples). Pearson's χ2 was used to test hypotheses about the significance of differences between frequencies, as well as the relationship between qualitative variables measured on nominal and ordinal scales. The purpose of the study is to examine the activities of human resources services of public sector dental organisations, identify priority problems and develop proposals for improving their work. Results. Staff turnover, vacancy filling and staff satisfaction were assessed as satisfactory. However, the work of the Human Resources Department is ineffective in key strategic areas such as human resources policy, the technologies used to manage labour relations, the development of motivation policies and the provision of resources (identification of human resources needs and the creation of a human resources reserve). Conclusion. The results of the study of the work of HR management services allowed to conclude that their activities do not meet the requirements of modern management. Modernisation of these services is impossible without mandatory training of personnel in HR management and development of unified standards of operating procedures for HR technologies.
PROTECTION OF ATMOSPHERIC AIR AND AIRSPACE OF UKRAINE: LEGAL, REGULATORY, ENVIRONMENTAL AND ECONOMIC ASPECTS
Authors: Kolomoiets Tetiana , Gordienko Artur , Yevtushenko Daria
Published: September 2024

The study uses general scientific and special methods, the main of which are: abstract-logical, deductive, inductive, historical, modelling and forecasting, methods of system-structural, system-functional analysis, economic and statistical (grouping, comparison, etc.). The use of system analysis methods made it possible to structure the constituent elements of the regulatory and legal support of public administration in the field of protection of atmospheric air and airspace of Ukraine. The purpose of the article is to characterise the protection of atmospheric air and airspace of Ukraine in the regulatory, legal, environmental and economic aspects. It is determined that the regulatory framework for regulating the principles of atmospheric air safety is a component of the mechanism for ensuring environmental safety. The article emphasises that for the first time the principles of environmental safety were enshrined in the Declaration of State Sovereignty of Ukraine, where the principles of environmental safety were established at the level of a separate section. It is emphasised that the functional content of the administrative and legal protection of atmospheric air includes: ensuring air pollution within the limits of the maximum permissible emission standards in order to ensure the right of a person to a safe and quality environment; greening of production; introduction of ecological fuel quality standards; greening of the energy cluster of the economy, including through the introduction of the principles of decentralisation of the country's energy system; establishment of information interaction between the participants of legal relations in order to ensure the transparency of economic activities related to environmental pollution; formation of a high level of environmental legal awareness, etc. The article draws a conclusion that ensuring proper quality of atmospheric air is a component of the mechanism for ensuring environmental safety. The authors underline that the understanding of the system of regulatory and legal regulation of atmospheric air and airspace protection should be functionally aimed at ensuring compliance with environmental standards for the operation of such facilities in accordance with economic feasibility and social justification. The paper concludes that atmospheric air safety and airspace safety are part of the national security system, where the former is a component of environmental safety and the latter is a component of state security, and should be understood as the state of atmospheric air and the integrity of the air environment, for which physical, chemical and biological properties are established which create favourable and sufficient conditions for the vital activity of people and settlements.
MODERN FEATURES OF INTERNATIONAL ECONOMIC HUMAN RIGHTS IN THE CONTEXT OF MILITARY AGGRESSION
Authors: Minchenko Raisa , Pidhorodynskyi Vadym , Stefanchishen Roman
Published: September 2024

The subject of the study is modern features of international economic human rights in the context of military aggression. Methodology. The methodological basis of the research is the methods of induction and deduction, the dialectical-materialistic method, the method of analysis and synthesis, the historical method, which made it possible to objectively understand the content and essence of the studied issues. The aim of the purpose of the work is to identify the origin, give the necessary classification of international economic rights and demonstrate, using the example of Ukraine, the mechanisms of their guarantee and protection in the conditions of military aggression. The results of the study have shown that in modern conditions of military aggression, there is an effective mechanism for ensuring economic human rights, which in particular is provided by means of "hard" and "soft" international law. Conclusion. Economic rights are closely related not only to social rights, but also to human rights belonging to other categories, which, in particular, allows us to conclude that it is impossible to unambiguously assign existing rights to only one of the internationally recognized groups and makes it meaningless to classify human rights according to this criterion (sphere of life). Summing up the analysis of the role of acts of "soft" international law in regulating cooperation between States to prevent and overcome financial and economic crises during war and full-scale military aggression, which directly affect the economic rights of citizens, it should be noted that such acts, first of all, contribute to the formation of a uniform conceptual apparatus in the field under consideration, partially entrenched in legally binding documents. In addition, advisory acts, as the basis for regulating relations to prevent and overcome financial and economic crises caused by military aggression and affecting the economic rights of citizens, are presented to a greater extent at the universal level, where contractual agreement of the will is not always achievable due to the difference in the economic interests of States. Given the general recognition, time of existence and practical applicability of the provisions of certain advisory acts on maintaining financial and economic stability, it makes sense to raise the question of considering them as international customs, sources of international law that contribute to maintaining guarantees of economic human rights in conditions of military aggression.
ANALYSIS OF INVESTMENT ACTIVITIES IN THE AGRICULTURAL SECTOR OF UKRAINE: DETERMINATION OF FACTORS AND WAYS OF ITS ACTIVATION
Authors: Tomashuk Inna , Khaietska Olha , Boltovska Liudmyla
Published: September 2024

The purpose of the article is to study the theoretical aspects of investment activity, analyse the current level of investment activity in the agricultural sector of Ukraine's economy and identify factors and methods of its increase. Methodology. The theoretical and methodological basis of the study is the fundamental principles of national economic management, investment activity and development of agricultural production entities. The research used the following scientific methods: axiomatic (to establish basic definitions that clarify the essence of the study), systematic (to identify components within the agricultural production sector), institutional (to construct the subject-object framework of the institutional environment for investment activity in agricultural production), correlation-regression analysis (to identify key predictors influencing investment activity in the agricultural sector), abstraction (to prioritise the stimulation of investment activity in agricultural production), and reproductive (to substantiate alternative strategies for attracting investment in agricultural enterprises). The results of the study show that diversification of investment sources and modernisation of technological infrastructure of agricultural production are important prerequisites for institutional reforms in the agricultural sector of the country. Increasing investment activity in agricultural enterprises can be achieved by creating a favourable investment climate. This includes government initiatives to create a transparent and stable regulatory framework, simplify bureaucratic processes, and ensure legal and financial stability. Another key aspect is to facilitate access to financial instruments such as low-interest loans, grants and subsidies to support the development of agricultural enterprises. The results of the study are presented in the form of tables, figures, graphs, diagrams and charts. Practical implications. Given the high level of integration of the domestic agricultural sector into the global food market, it is worth exploring the potential of using customs instruments to stimulate investment processes. Such instruments could include a zero VAT rate for investment agricultural goods and measures to prevent double taxation. Value / Оriginality. Investment activity in Ukraine can be intensified under the following conditions: ensuring financing for innovations; developing and implementing a system of measures to increase the investment activity of commercial banks; promoting the development of the stock market and venture capital; developing investment infrastructure; borrowing the best international experience in assessing the efficiency of business centres and business incubators; forming an investment and innovation culture in society, etc.
COMPARATIVE ANALYSIS OF SMART ECONOMY DEVELOPMENT IN SELECTED COUNTRIES OF SOUTHEAST ASIA
Authors: Tsymbal Liudmyla , Verdenhofa Olga , Natsvlishvili Tymur
Published: September 2024

Research subject. The development of the global economy indicates the formation of a new trend in the formation of the smart economy, which currently covers both developed and developing countries. According to the analysis, developed countries are leaders in economic development precisely because of the development of technologies that are the basis for the formation of the smart economy and the smart intellectualisation of economic activity. The smart economy in Asia is actively developing due to the intensive introduction of the latest technologies, innovative management approaches, and increased resource efficiency. Asian countries such as China, Japan, South Korea, Singapore, and India are leaders in the development of the smart economy. At the same time, Asian countries have been demonstrating one of the highest rates of economic development since the beginning of the XXI century, which is primarily due to the active technologisation of production and the spread of communication technologies in all areas of economic activity. Several technology centres are emerging in Asia, concentrating technology companies and creating a favourable environment for the development of the smart economy. Methodology. The article conducts a comparative analysis of the factors contributing to the development of the smart economy in individual Asian countries, identifies the most influential factors and the degree of their impact on each country. The purpose of this study is to identify the factors influencing the development of the smart economy and compare their impact in the economies of China, India and Singapore. To achieve this goal, the following research objectives are envisaged: to identify factors that have a significant impact on the development of the smart economy in different countries; to assess the impact of individual factors on the development of the smart economy in China, India and Singapore; to compare the impact of individual factors of the smart economy on the economies of these countries; and to assess the models of smart economy development in China, India and Singapore. Conclusion. The smart economy in Asia is characterised by unique features that reflect the cultural, technological and economic conditions of the region. The key features of the Asian smart economy include a high level of digitisation and technological integration, active development of smart cities, financial technologies (FinTech), a focus on automation and robotics, innovation hubs and support for start-ups, environmental sustainability and green energy, and the digitalisation of governance and public services. Asian countries are also distinguished by the integration of smart technologies into the everyday life of citizens and the support of innovation ecosystems at the state level.
SYNTHETIC INDICATORS OF QUALITY OF LIFE: EVALUATION OF THE EFFECTIVENESS OF UKRAINE'S ECONOMIC POLICY
Authors: Artemenko Olena , Artemenko Viktor
Published: September 2024

This paper examines the effectiveness of Ukraine's economic policies through the lens of quality of life and argues for the adoption of a minimal set of evaluation criteria, ideally a single composite criterion, to optimise policy evaluation. Despite ongoing efforts to identify such criteria, the study introduces a novel approach by using synthetic indicators of quality of life as the basis for evaluation. This approach is particularly relevant in the context of Ukraine's post-war recovery and its aspirations towards European Union integration. These conditions require the adoption of economic policies that meet European standards of quality of life and facilitate the necessary reforms. Such policies are crucial for improving the living conditions of the Ukrainian population and facilitating the return of refugees after Ukraine's victory over Russia, the aggressor country. This study develops a methodology that uses synthetic indicators of quality of life as a system of criteria to assess the effectiveness of Ukraine's economic policy. The research involves a cross-country analysis of data from seven EU Member States and Ukraine, and the construction of regression models that link the determinants of state economic policy to several indicators: population quality, welfare, social quality, and a comprehensive synthetic indicator – quality of life. The obtained results confirm the hypothesis about the key parameters of the state economic policy as determinants of improving the quality of life of Ukrainian citizens. In addition, the analysis of the dynamics of synthetic indicators of the quality of life in Ukraine and their determinants makes it possible to identify priority areas of economic policy aimed at improving these indicators, which will contribute to the overall efficiency of Ukraine's economic policy.
THE THEORY OF TRANSFORMATION OF INTELLECTUAL PROPERTY LEGAL REGIMES USING BLOCKCHAIN TECHNOLOGIES: INTERNATIONAL CONTEXT
Authors: Bignyak Oleksandr , Mazurenko Svitlana , Ivanchenko Olga
Published: September 2024

This article is dedicated to the study of the theory of transformation of intellectual property legal regimes through blockchain technologies on an international scale. It focuses on three thematic blocks: firstly, defining the essence of blockchain technologies; secondly, analysing international blockchain technology standards; and thirdly, exploring variations in the use of blockchain technologies for the registration of intellectual property objects. The subject of the study is the social relations in the field of intellectual property and the mechanisms for their regulation. Methodology. The article employs scientific methods of cognition and doctrinal resolution of issues related to the use of digital tools in the regulation of social relations. This encompasses formal-logical and dialectical methodologies. A variety of empirical techniques, including synthesis, deduction, and statistical analysis, were employed. Results. The study reveals the absence of a direct indication of the use or intent to use distributed ledger technology, otherwise known as blockchain technology. The study demonstrates the significance of utilising blockchain technology in maintaining the customs register to account for intellectual property objects protected by law. This ensures the impossibility of unauthorised alteration or deletion of information about intellectual property objects, as provided by distributed ledger technology. These legal relations emerge in the course of entering information into the aforementioned registers, making modifications (updates), and providing information to interested parties. The use of blockchain technologies in the formation of the register of issued certificates of state registration of copyright for a work is justified.