bluuebunny/crossref_metadata_2025 huggingface dataset:
New Dimensions Regarding Demographic Behavior and Family Stability in Romania and Bihor County: A Comparative Analysis
Authors: Stasac Marcu , Stupariu Marius I. , Tatar Corina Florina , Linc Ribana , Bucur Liviu , Nistor Stelian
Published: July 2023

A nation's vitality, dynamism and economic strength will always be related to its demographic component, and a healthy and vigorous population will ensure its long-term future. However, the current realities demonstrate the existence of an obvious population decrement at the level of the entire country particularly triggered by the birth rate decrease and the high demographic aging to which other factors add ap specific to local communities, which in their turn determined a particular type of demographic behaviour. Therefore we aim to analyze those elements with a major population dynamics impact such as family stability and demographic potential that can generate a specific demographic behaviour, as a result of the major changes that have occurred in the last period of time. These elements are translated through several demographic indicators that characterize the family, such as the nuptiality index and the divorce index whose evolution was registered and analyzed for the period 1992-2021. Their evolution indicates the demographic potential of Romania, as well as of Bihor county.
Enhancing Crop Yields through CRISPR Technology: A Promising Approach for Sustainable Agriculture
Authors: Marshall Kenneth
Published: July 2023

Crop yield enhancement is crucial for ensuring food security and meeting the growing global demand for agricultural products. The development of innovative technologies, such as CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), has provided new avenues for precise genetic modifications in crops. In this research article, we explore the application of CRISPR technology for crop yield improvement. We discuss the methodology, present recent results, and engage in a comprehensive discussion of the potential benefits, challenges, and future prospects of CRISPR-mediated crop yield enhancement.
Understanding the Characteristics of Vertical Structure for Wind Speed Observation via Wind-LIDAR in Jeju Island
Authors: Yi Dong-won , Lee Sang-Sam , Choi Hee-Wook , Lee Yong Hee
Published: July 2023

The wind observations for multiple levels (40–200 m) have been conducted for a long time (2016–2020) on Jeju Island of South Korea. This study aims at understanding the vertical and temporal characteristics of lower atmosphere. Jeju Island is a region located at mid-latitude and is affected by seasonal monsoon wind. The maximum wind speed appears in the lower layer during day time and is delayed in the upper layer during latter time in diurnal cycle. In summer season, the surface layer increases up to 160 m during day time via dominant solar radiation effect, which is higher than those for other seasons. However, the maximum wind speed in winter season appears irregularly among altitudes, and the surface layer is ~100 m, which is lower than that in summer season. It can be attributed to the increase in the mean wind speed in diurnal cycle caused by the strong northwestern wind for winter season. These results imply that the relationship between near-surface and higher altitudes is primarily affected by solar radiation and seasonal monsoon winds. These results are expected to contribute to site selection criteria for wind farms and to the assessment concerning planetary boundary layer modeling.
Energy-Saving Adaptive Routing for High-Speed Railway Monitoring Network Based on Improved Q Learning
Authors: Fu Wei , Peng Qin , Hu Canwei
Published: July 2023

The high-speed railway operation environment monitoring network system has a wide variety of sensors and inconsistent business requirements, which have certain requirements for data transmission delay and network life. Most of the previous research focuses only on prolonging network lifetime or reducing data transmission delays when designing or optimizing routing protocols, without co-designing the two. In addition, due to the harsh operating environment of high-speed railways, when the network changes dynamically, the traditional routing algorithm will generate unnecessary redesigns and lead to high overhead. Based on the actual needs of high-speed railway operation environment monitoring, this paper proposes a novel Double Q-values adaptive model combined with the existing reinforcement learning method, which considers the energy balance of the network and real-time data transmission, and constructs energy saving and delay. The two-dimensional reward avoids the extra overhead of maintaining a global routing table while capturing network dynamics. In addition, the adaptive weight coefficient is used to ensure the adaptability of the model to each business of the high-speed railway operation environment monitoring system. Finally, simulations and performance evaluations are carried out and compared with previous studies.Finally, simulations and performance evaluations are carried out and compared with previous studies. The results show that the proposed routing algorithm successfully extends the network’s life cycle and gets good real-time data performance. It also saves energy and has fewer delays than the other three routing protocols in different situations.
The Effect Of The Addition Of Db Killer On The Noise Of Yamaha Vixion 150cc Racing Motorcycle
Authors: Jagadhita Phaundra Rexha , Akbar Ali
Published: July 2023

Indonesia is one of the countries that has experienced a significant increase in the number of motorcycle vehicles, especially the Yamaha Vixion motorcycle, which is a sport-type motorcycle, a motorized vehicle which causes noise pollution arising from excessive noise levels. The aim of the study was to find out the results of the analysis of the noise level produced by motorbikes between standard and racing exhausts using the Intact-Group Comparison experimental research method. Experimental group (treated) and control group (no treatment). Population of all types of motor vehicle exhaust, sample 2 types of exhaust, namely standard and racing. the independent variable is the use of standard exhaust and racing exhaust on motorbikes. The dependent variable is noise level. The HC compound on the standard exhaust compared to the Racing R9 exhaust can significantly reduce HC exhaust emissions. The standard exhaust CO compound is better than racing exhaust. So the noise level and exhaust emissions of racing exhausts are higher than standard exhausts. So that racing exhaust is more dangerous if it is used frequently because it contains a noise level that is too high.
Product Needs Planning For Distribution Fulfillment With Double Exponential Smoothing And Distribution Requirements Planning Methods
Authors: Natadiharja Sebastian Arya , Wulandari Indah Apriliana Sari , Sukmana Tedjo , Cahyana Atikha Sidhi
Published: July 2023

PT. KINI is a company engaged in the distribution of Indosat products. In the distribution process, there is often a shortage of stock for the Voucher type, and there is an excess stock for the SP type. The purpose of this research is to plan product needs before distribution, especially for products that often experience stock shortages. The application of the Double Exponential Smoothing forecasting method, and Distribution Requirement Planning are expected to overcome problems in the lack of fulfillment of product needs. The results of the research showed that the quantity of economical orders based on forecasting on V 3 in 1 products was 18,345 frequency of ordering 6 times, FI 1.5 GB of 11,715 frequency of ordering 4 times, FI 2.5 GB of 12,236 frequency of ordering 4 times, FI 5, 5 GB of 10,075 message frequencies 3 times, 3 GB FI of 11,874 message frequencies 4 times, and 9 GB FI of 6,566 message frequencies 2 times. The conclusions obtained from the development of the DES and DRP methods are the most economical order quantity, and the right time to order to overcome shortages in stock data voucher type products.
IMPLEMENTASI CORPORATE SOCIAL RESPONSIBILITY (CSR) DI ERAMART SAMARINDA DALAM PERSPEKTIF EKONOMI ISLAM
Authors: Syahrullah Syahrullah , Iswadi Muhammad , Tikawati Tikawati , Hasbi Muhamad
Published: July 2023

Corporate Social Responsibility (CSR) merupakan sebuah gagasan yang menjadikan perusahaan tidak hanya  bertanggung jawab pada nilai perusahaan saja, tetapi juga berpijak pada kegiatan ekonomi, sosial dan lingkungan dari sebuah entitas. CSR di perlukan sebagai suatu komitmen berkelajutan dari perusahaan untuk bertanggung jawab secara ekonomi sosial, dan ekologis kepada masyarakat, lingkungan, serta para pemanggku kepentingan (Stageholder). Sehingga dalam pelaksanaan kegiatan Corporate Social Responsibility oleh Eramart Samarinda terdapat beberapa jenis yang di lakukan oleh perusahaan dalam mengimplementasikan kegitan CSR Maka peneliti ingin melakukan penelitian di suatu perusahaan ritel lokal di Samarinda dengan tujuan untuk mengetahui bagaimana implementasi program kerja Corporate Social Responsibility (CSR) yang ada di Eramart Samarinda serta apakah implementsinya sesuai dengan prinsip Ekonomi Islam. Adapun metode yang di gunakan dalam penelitian ini adalah Tield Research (Lapangan) dengan jenis Kualitatif – deskriptif menggunakan analisis isi (Content Analisis) data yang dianalisis yaitu data yang terbagi menjadi dua yakni data primer berupa data langsung dari PT Eramart group dan data sekunder berupa refrensi teori serta dalam teknik pengumpulan data menggunakan Dokumentasi, Observasi, dan Wawancara.Hasil penelitian ini menunjukkan bahwa Implementasi Program Corporate Social Responsibility di Eramart Samarinda dalam bidang pendidikan dan sosial diantaranya 1) dengan menggunakan pola implementasi melalui yayasan atau organisasi perusahaan dengan mendirikan Yayasan Rumah Tahfidz. 2) Implementasi keterlibatan langsung dengan memberikan bantuan kepada yayasan panti asuhan Darul Falah  berupa dana dan sembako. 3)  Implementasi kerjasama dengan lembaga sosial atau organisasi non Pemerintah. Implementasi Program Kerja Corporate Social Responsibility (CSR) di Eramart Samarinda menggunakan  prinsip ekonomi Islam di antaranya Prinsip keadilan, Prinsip Raḥmatan Lil‟alamῑn dan Prinsip Maslahah (Kepentingan Masyarakat).
Pemberdayaan Ekonomi Masyarakat Melalui Pengembangan Pariwisata Dalam Perspektif Ekonomi Islam (Studi Di Pantai Biru Kersik Kecamatan Marang Kayu)
Authors: Sari Desi Ratna , Norvadewi N , Pratiwi Angrum
Published: July 2023

Efforts to empower the community's economy in the tourism sector have been regulated and contained in Law No. 10 of 2009. One of the areas that are currently empowering and developing tourism potential is Marang Kayu District, located in Kutai Kartanegara Regency, East Kalimantan Province. One of the attractions owned by Marang Kayu District is Blue Beach Kersik which is located in Kersik Village. The development of the potentials that exist on the beach has received attention from the government as seen from the selection of Kersik Village as one of the Tourism Villages in Kutai Kartanegara Regency, East Kalimantan. Community economic empowerment through tourism villages is expected to be able to contribute to the economy, either directly or indirectly to the local community and in improving social life. Judging from the purpose of this study, namely to find out the model of community economic empowerment through tourism development at Blue Beach Kersik and to determine community economic empowerment through tourism development at Blue beach Kersik in an Islamic economic perspective.This type of research is a field research and a descriptive qualitative approach. Sources of data in this study using primary data, in this study data collection techniques through observation, interviews with the informant Head of Kersik Village, Tourism Awareness Group which collected three people, and business owners who opened seven people. With data analysis techniques, namely data reduction, data presentation and conclusion drawing.Based on the results of this study, it shows that the model of community economic empowerment through the development of Blue Beach Kersik tourism is seen from the form of empowerment through micro, small and medium enterprises. empowerment strategy by developing a creative economy and the use of social media, community participants and the government. The economic independence of the community comes from the use of the beach in Kersik Village so that it has an impact on the community's economy. from the view of Islamic Economics that community economic empowerment through tourism development at Blue Beach Kersik has been carried out in a good way so as to provide benefits and welfare for people's lives.
DIGITALIZACIÓN Y SOSTENIBILIDAD SOCIETARIA: UN NUEVO IMPULSO A UN PROYECTO PRETÉRITO
Authors: Ravelo Guillén Fernando Javier
Published: July 2023

A pesar de que la modernización y, en particular, la digitalización de las corporaciones ha constituido uno de los objetivos más relevantes de los últimos tiempos, no podemos negar que, ante los retos actuales, la digitalización generalizada del Derecho y, en particular, del Derecho de sociedades, precisa de un impulso decisivo al ser un instrumento esencial para lograr mejoras en la productividad y competitividad. No obstante, la digitalización de las sociedades ha de perseguir en todo momento otro gran objetivo: la sostenibilidad empresarial. Y es que las empresas han de avanzar en el camino de la digitalización manteniendo, en todo momento, un equilibrio con el compromiso de lograr un desarrollo sostenible.
Effects of Calcium Supplementation on Changes in the Il2, Il4, Il6, Il10 Axes and Oxidative Stress in Pregnant Women at Risk for Pre-eclampsia: Clinical Trial
Authors: Pitilin Erica Brito , Marafon Filomena , Bonadiman Beatriz da Silva Rosa , Pelazza Bruno Bordin , Pillat Micheli Mainardi , Lara Jéssica Dotto , Oliveira Patrícia Pereira , Bagatini Margarete Dulce , Schirmer Janine
Published: July 2023

Background
Pregnant women with hypertensive disorders are at increased risk for inflammatory diseases and oxidative stress. The dilemma raised by the best dosage of calcium supplementation on these factors is evident. The aim of the current study was to examine the effects of calcium on biomarkers of the purinergic system, inflammation and oxidative stress, which are factors contributing to vascular damage in pregnant women at high risk of pre-eclampsia.
Methods
A prospective, double-blind and placebo-controlled study conducted with 101 women at risk of pre-eclampsia were randomized to take 500 mg calcium/day or 1,500 mg calcium/day or placebo for 6 weeks from the 20th gestational week until delivery. Fasting blood samples were collected at the beginning of the study and 6 weeks after the intervention.
Results
Taking calcium supplements (500 mg calcium/day) led to a significant increase in ATP hydrolysis (p < 0.05), NTPDase activity with increased hydrolysis of ADP and AMP nucleotides in platelets and lymphocytes. In the intragroup analysis IL-2, IL-6, IL-4 and interferon-ɣ presented lower values in the calcium 1,500 mg/day group (p < 0.005). Oxidative stress was assessed by TBARS pro-oxidant marker, with an increase for the calcium groups when compared to the placebo group. The Vitamin C antioxidant marker presented a significant increase (p < 0.005) for the group that received high calcium doses.
Conclusions
Calcium administration for 6 weeks had antioxidant action and positively modulated the purinergic system and inflammatory markers in pregnant women at risk of pre-eclampsia.
Two-step hot isostatic pressing densification achieved non-porous fully-densified wood with enhanced physical and mechanical properties
Authors: Correa Esteban , Maturana Juan , Guindos Pablo , Lagos Jorge , Arroyave Catalina , Echeverría Félix
Published: July 2023

A new two-step densification method for wooden materials is proposed. This method achieved wood that was virtually non-porous and fully densified exceeding any value ever reported for a hardwood species. In the first step, the compressive strength of the anatomical wood structure is reduced by delignification, and, in the second, a full densification is achieved by hot isostatic pressing under argon atmosphere. Three tropical hardwood species with distinct anatomical characteristics and properties were used to test the method. The HIP-densified wood's microstructural, chemical, physical, and mechanical properties were assessed. The results indicate that proposed method was effective for all the tested species, obtaining a material that it is mostly non porous, shows homogenous density patterns, preserves the original volume, features great stability and it has enhanced mechanical properties. Therefore, the HIP wood densification may be a promising densification technique since it overcomes several limitations faced by previous wood densification methods.
Non-Markovian cost function for quantum error mitigation with Dirac Gamma matrices representation
Authors: Ahn Doyeol
Published: July 2023

This paper investigates the non-Markovian cost function in quantum error mitigation (QEM) and employs Dirac Gamma matrices to illustrate two-qubit operators, significant in relativistic quantum mechanics. Amid the focus on error reduction in noisy intermediate-scale quantum (NISQ) devices, understanding non-Markovian noise, commonly found in solid-state quantum computers, is crucial. We propose a non-Markovian model for quantum state evolution and a corresponding QEM cost function, using simple harmonic oscillators as a proxy for environmental noise. Owing to their shared algebraic structure with two-qubit gate operators, Gamma matrices allow for enhanced analysis and manipulation of these operators. We evaluate the fluctuations of the output quantum state across various input states for identity and SWAP gate operations, and by comparing our findings with ion-trap and superconducting quantum computing systems' experimental data, we derive essential QEM cost function parameters. Our findings indicate a direct relationship between the quantum system's coupling strength with its environment and the QEM cost function. The research highlights non-Markovian models' importance in understanding quantum state evolution and assessing experimental outcomes from NISQ devices.
CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity
Authors: Chen Jiasheng , Lin Yuxin , Zheng Shukai , Chen Qingshan , Tang Shijie , Zhong Xiaoping
Published: July 2023

Background: A chromobox homologue 3(CBX3) is elevated in various cancers and significantly contributes to the promotion of malignant behavior; despite this, its exact involvement in clear cell renal cell carcinoma (ccRCC) is yet unknown.
Methods: The Cancer Genome Atlas database served to evaluate CBX3 production and its connection to survival in patients with ccRCC. Our team evaluated the effects of knockdown of CBX3 levels in ccRCC cell populations using in vitro together with in vivo models. CBX3, proteins related to death, and EMT-related proteins were measured in ccRCC cells using western blotting and immunohistochemical assays. Through the analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) and GeneOntology (GO) and Gene Set Enrichment Analysis (GSEA), the biological processes and signal pathways related to CBX3 expression were identified. Immune-related activity reduced by CBX3 was assessed using various online tools.
Results: Both genomic and protein expression showed that CBX3 was upregulated in ccRCC. Further functional analyses revealed that CBX3 played a crucial role in enhancing cell growth, migration, and epithelial-to-mesenchymal transition (EMT) in vitro along with in vivo. Moreover, we provide distinct mechanistic evidence that CBX3 achieves all its pathological functions in ccRCC by activating the PI3K/AKT pathway. Finally, immunoassays revealed that CBX3, a possible biomarker of ccRCC, was significantly associated with immunity.
Conclusions: Our results suggest that CBX3 is overexpressed and promotes ccRCC advancement through PI3K/AKT activation and even immunological dysregulation, making it a potentially viable and beneficial target.
Structural and intermediary socioeconomic determinants of health associated with hospitalizations and doctor visits in older adults in Europe.
Authors: Amo-Saus Elisa , Martínez-Lacoba Roberto , Pardo-García Isabel , Moya-Martínez Pablo
Published: July 2023

The aging population in Europe has increased the demand for healthcare, with doctor visits and hospitalizations being key indicators of this trend. This demand is influenced by various individual and lifestyle factors, as well as structural and systemic macrovariables that cannot be modified through behavioral changes. This study aimed to investigate inequalities in access to healthcare across European countries, finding that macrovariables explained between 3.3% and 4.9% of the differences in the likelihood of hospitalizations and approximately 10% of the likelihood of visiting a doctor at least once a year. Life expectancy and number of beds were the macrovariables most associated with a reduced probability of hospitalization and doctor visits, respectively. The study also found that comorbidity and employment status were risk factors associated with hospitalization and doctor visits, while physical activity was a protective factor. These findings are useful in developing healthcare policies at the European level.
Identification of common hub genes in gastrointestinal cancers and their role in prognosis and Immune cell infiltration in hepatocellular carcinoma
Authors: Yang Cheng-Lei , Chen Bing-Sheng , Li Shuai-Jun , Hu Jun-Wen , Li Yuan-Kuan , Wu Zong-Ze , Zhou Min , Song Rui , Yu Hong-Ping , Xiang Bang-De
Published: July 2023

Background
Common hub genes (CHGs) in gastrointestinal cancers (GICs) and their prognostic potential and immune infiltration in hepatocellular carcinoma (HCC) are limited.
Methods
Differential analysis of genes in the six GICs was performed, and CHGs were identified using the survival and protein-protein interaction (PPI) network analyses. A polygenic prognostic model was constructed based on the CHGs using the LASSO-Cox regression algorithm and validated in two cohorts. CHGs-related multivariate Cox regression and immune infiltration analyses were performed.
Results
Ten CHGs (TOP2A, CCNB1, CDK1, MAD2L1, RRM2, CCNA2, BUB1B, CDC6, AURKA, and BUB1) were obtained. In The Cancer Genome Atlas (TCGA) cohort, a 3-gene (CCNB1, MAD2L1, and BUB1) prognostic model was built. A significant difference was showed in the overall survival of patients between the two groups. Moreover, both type I and II interferon response pathways decreased in high-risk HCC patients. These results were also validated in the ICGC and internal cohorts.
Conclusions
10 CHGs in six GICs was revealed. In HCC, a prognostic model based on the 3 CHGs in GICs was constructed. Both type I and II interferon response pathways markedly decreased in the high-risk group of HCC patients. This might provide novel perspectives for the targeting and immunotherapy of GICs.
Expression of CYP4X1 in colorectal carcinoma is associated with metastasis and poor prognosis
Authors: Kim Sooyoun , Hong Inpyo , Lee Minho , Kim Hak Chun , Ji Sanghee , Kim Hyeongjoo , Kwak Hyoung Jong , Kim Chang-Jin , Jeong Dongjun
Published: July 2023

Background
Colorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate. The recurrence rate of colorectal cancer is 30–50%, and the survival rate of patients with recurrence and metastasis is very low. Prognostic biomarkers of colorectal cancer can be guidelines for the therapeutic management of the cancer patients. The cytochrome P450 (CYP) family is upregulated in various cancers and contributes to cancer cell proliferation, signaling and drug metabolism. In addition, the Cytochrome P450 family is related to various xenobiotics and endogenous compounds. Nevertheless, the role of CYP4X1 in regulating the progression and growth of colorectal cancer remains unclear.
Methods
To investigate the relationship between CYP4X1 expression and colorectal cancer, CYP4X1 expression was inhibited in colorectal cancer cells using siRNA and confirmed at mRNA and protein levels. WST-1, Transwell and colony formation assays were performed using CYP4X1 downregulated cells. We performed immunohistochemistry for the CYP4X1 expression of 243 colorectal cancer tissues and investigated the expression with the patient’s clinical parameters.
Results
In colorectal cancer, downregulated CYP4X1 suppressed proliferation, migration, invasion, and colony formation. CYP4X1 overexpression was found to be related to TNM stage, degree of tumor differentiation, invasion of the primary tumor, clinical stages, and lymph node metastasis. In addition, the high CYP4X1 expression revealed a shorter survival period than those with low CYP4X1 expression by Kaplan-Meier survival analysis.
Conclusions
Upregulated CYP4X1 may be an independent prognostic marker for CRC, and CYP4X1 may be a therapeutic target for CRC patients. Epoxyeicosatrienoic acid (EET) derived from arachidonic acid has been implicated in carcinogenesis due to its CYP polymorphism. Whether CYP4X1 regulates EET in CRC remains unknown. Therefore, the increased CYP4X1 in EET requires further studies on the correlation between EGFR phosphorylation and PI3K/AKT and MAPK signaling.
Antibacterial and swelling performance of superabsorbent polymers incorporated with magnesium oxide nanoparticles
Authors: Noor Hafiz Muhammad Zia ul , Ahmad Ali , Rafique Sikander , Akram Naeem , Durrani Abdullah Khan
Published: July 2023

Super absorbent copolymer incorporated with magnesium oxide nanoparticles was investigated for absorptivity in an aqueous solution and anti-bacterial activity against gram-negative Escherichia Coli. Cross-linked copolymers of ionic acrylic acid (A.A.) and nonionic acrylamide (AAm) were synthesized in an aqueous solution via free radical polymerization by providing vigorous mixing and heating. MgO nanoparticles were incorporated into the super-absorbent copolymers during polymerization. For all preparations, the degree of neutralization of acrylic acid was fixed at 75%, the amount of cross-linker NN-MBA was 1% moles of initial monomer, and the initiator potassium persulfate amount was 150 mg. The highest absorption of distilled water was 147 g/g at 80% acrylic acid without MgO nanoparticles content (AA30M). While in 0.9% saline solution, the highest absorption capacity was 39 g/g at 40% acrylamide content (AA10M). Reduced swelling ability was observed by increased magnesium oxide nanoparticles dosage as 121.5 g/g in AA33M copolymer. However, maximum bactericidal activity was observed for AA33M on the agar plate method and Lysogeny broth medium method via UV-spectrophotometer, where the optical density (O.D.) 600 was 0.022. This study is expected to provide a viable solution due to its eco-friendliness, ease of availability, and low cost.
Prioritizing Educational Initiatives on Emerging Technologies for Italian Pediatricians: bibliometric review and a survey
Authors: Tozzi Alberto Eugenio , Gesualdo Francesco , Pandolfi Elisabetta , Ferro Diana , Cinelli Giulia , Bozzola Elena , Aversa Tommaso , Mauro Antonio Di , Mameli Chiara , Croci Ileana
Published: July 2023

Background
Emerging technologies have demonstrated outstanding potential in improving healthcare, yet their full integration remains a challenge for all medical specialties, including pediatrics. To support the swift implementation of technologies, we identified the current trends through a bibliometric review, and we conducted a survey on Italian pediatricians to gauge educational needs and willingness to integrate technologies into clinical practice.
Methods
A working group of pediatricians representing various backgrounds designed and coordinated the study. To identify relevant topics for educational strategy development, we focused on virtual reality, telehealth, natural language processing, smartphone applications, robotics, genomics, and artificial intelligence. A bibliometric analysis limited to 2018-2023 was performed to identify trends and emerging applications within each topic. Based on the results, a questionnaire was developed and made available online to all Italian pediatricians. The results were analyzed through descriptive analysis and a multivariable logistic regression to explore associations between technology adoption and sociodemographic characteristics.
Results
A total of 3,253 publications were found, with Telehealth and Telemedicine having the highest number of publications and Natural Language Processing the lowest. The number of respondents to the online questionnaire was 1,540, predominantly medical doctors with over 20 years of experience working as family pediatricians. Telehealth had the highest level of knowledge (95.2%), followed by smartphone applications (89.1%) and genomics (63.2%). The greatest potential for increased use through education programs was projected for natural language processing (+43.1%), artificial intelligence (+39.6%), and virtual and mixed reality (+38.1%). Female respondents and older individuals were less likely to use emerging technologies. Hospital pediatricians and residents were more likely to use AI.
Conclusions
We developed a replicable strategy to identify emerging themes in medical technologies relevant to pediatrics and assess the educational needs of pediatricians. A significant gap still exists between current and potential usage of emerging technologies among Italian pediatricians although they showed a positive attitude towards implementing these technologies following specific education programs. The study highlights the need for comprehensive education programs on emerging technologies in pediatrics and recommends addressing gender and age disparities in technology adoption.
Causal Relationship between Multiple Autoimmune Diseases and Pregnancy Loss: A Two-Sample Mendelian Randomization Study
Authors: Chen Liang , Guo Juanjuan , Xia Yi , Wang Mei , Zhang Yuanzhen , Yang Meitao
Published: July 2023

Background
Although systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) have been clinically confirmed to cause pregnancy loss and effective clinical treatment and nursing programs have been proposed to greatly improve pregnancy outcomes, the relationship between other types of autoimmune diseases (ADs) and pregnancy loss remains unclear due to inconsistent conclusions from existing observational studies. This has hindered the formation of clinical consensus and the implementation of comprehensive management for pregnant women with ADs. To address this gap, we executed a two-sample mendelian randomization(MR) approach intending to assess the potential causal impact of 29 ADs on 7 types of pregnancy loss.
Results
The two-sample MR investigations with inverse variance weighted(IVW) approach revealed strong causal relationship between broadly defined ADs and stillbirth, spontaneous miscarriage, or termination [Odd ratios (ORs), 1.00846; 95% confidence intervals (CIs), 1.00095–1.01602; p value = 0.027]. Type 1 diabetes (T1D) exhibited a positive link with the number of spontaneous miscarriages [OR, 1.00709; 95%CI, 1.00134–1.01288; p value = 0.016]. Meanwhile, autoimmune hypothyroidism was strongly linked to ever had stillbirth, spontaneous miscarriage, or termination [OR, 1.00413; 95%CI, 1.00043–1.00784; p value = 0.028]. Additionally, crohn's disease (CD), a gastrointestinal immune disease, exhibited a significantly positive correlation with spontaneous abortion [OR, 1.00036; 95%CI, 1.00012–1.00059; p value = 0.003]. Interestingly, we observed that rheumatoid arthritis (RA) indicated a negative connection with spontaneous abortion [OR, 0.99953; 95%CI, 0.99909–0.99997; p value = 0.036].
Conclusion
The findings of this study implied a causal association between different ADs and pregnancy loss, thus advancing our comprehension of the ADs-mediated etiology and pathogenesis of pregnancy loss.
Low Complexity Enhancement VVC Encoder for Vehicular Networks
Authors: Jiang Xiantao , Li Wei , Song Tian
Published: July 2023

In intelligent transportation systems, real-time video streaming via vehicle networks has been seen as a vital difficulty. The goal of this paper is to decrease the computational complexity of the Versatile Video Coding (VVC) encoder for VANETs. In this paper, a low complexity enhancement VVC encoder is designed for vehicular communication. First, a fast coding unit (CU) partitioning scheme based on CU texture features is proposed in VVC, which aims to decide the final type of CU partition by calculating CU texture complexity and gray level co-occurrence matrix (GLCM). Second, to reduce the number of candidate prediction mode types in advance, a fast chroma intra prediction mode optimization technique based on CU texture complexity aims to combine intra prediction mode features. Moreover, the simulation outcomes demonstrate that the overall approach may substantially cut down on encoding time, while the loss of coding efficiency is reasonably low. The encoding time can be cut by up to 53.29\% when compared to the VVC reference model, although the average BD-rate is only raised by 1.26\%. The suggested VVC encoder is also hardware-friendly and has a minimal level of complexity for video encoders seen in connected vehicle applications.
Bgnba-oco Based Privacy Preserving Attribute Based Access Control With Data Duplication for Secure Storage in Cloud
Authors: Pavithra M. , PRAKASH M , VENNILA V
Published: July 2023

Cloud computing technology offers flexible and expedient services which carry a variety of profits for both societies as well as individuals. In the epoch of data explosion, customers and business establishments require to store enormous data. The exception of cloud service advantages, data confidentiality becomes a challenging aspect to be covered as far as executing data access control. The implementation of Attribute-based Encryption in a Cloud Computing (CC) environment solves the demanding topic of outsourced data enabling fine-grained and pliable access control. In this work, a method called Boneh Goh Nissim Bilinear Attribute-based Optimal Cache Oblivious (BGNBA-OCO) access control and secure de-duplication for data storage in cloud computing is proposed. First, Boneh Goh Nissim Privacy Preserving Revocable Attribute-based Encryption is designed that reinforces attribute revocation and avert the discharge of sensitive information. Moreover, to prevent disclosure of access patterns Optimal Cache Oblivious algorithm is employed to hide the access patterns in cloud storage using rand pattern matching. It also supports updating both encrypted data and access control policies to minimize communication and computation overhead of data duplication and encryption processes concurrently. In this way, secure data sharing is performed to achieve higher data confidentiality and integrity. The analyzed results indicate that the BGNBA-OCO method offers an efficient solution in terms of achieving higher data confidentiality, and integrity, and minimizing the communication as well as computation overhead than the conventional techniques.
The Evolution of ‘Riskscapes’: 100 years of climate change and mountaineering activity in the Lake Louise area of the Canadian Rockies
Authors: Hanly Katherine , McDowell Graham
Published: July 2023

Climate change is contributing to the rapid warming of mountain environments, resulting in glacial retreat, diminished snowpacks, and permafrost thaw. These changes modify conditions and increase objective hazard on mountaineering routes, threatening the safety and wellbeing of mountaineers. In response, this study used a mixed-methods approach that combines statistical climatological analysis with archival-content analysis to examine the relationship between climate change, route conditions, hazards, and adaptations reported by climbers in the Abbot Pass area of Banff National Park (Canada). Results revealed an increase in temperature and decrease in total precipitation, corresponding with considerable changes in climbing conditions and increases in objective hazards on approach and popular climbing routes in the area. These changes can be classified based on the original character of the route and their climate-driven trajectory, creating a novel typology that informs how mountaineers adapt (i.e., spatial vs. temporal substitution). This typology has substantial implications for mountaineers as it could enhance their decision-making processes by allowing them to proactively develop plans that reduce exposure to objective hazards and capitalize on climate-related opportunities. However, our findings also highlight the potential inevitability of mountaineers encountering hard biophysical limits to adaptation, resulting in forced transformations and significant loss and damages. While focused on a Canadian context, the findings and methodologies developed herein are relevant to other mountain geographies, where climate change is rapidly transforming environments frequented by mountaineers and represents a call to action for more research in field of climate change, adaptation, and mountaineering.
Associations Between Velamentous or Marginal Cord Insertion and Risk of Adverse Perinatal Outcomes in Twin Pregnancies: A Retrospective Cohort Study
Authors: Wen Li , Zhong Qimei , Mei Lingwei , Gao Li , Lan Xia , Xiong Jing , Luo Shujuan , Wang Lan
Published: July 2023

Background
velamentous cord insertion (VCI) and marginal cord insertion (MCI) are well-known risk factors for adverse perinatal outcomes in singleton pregnancies. However, the potential links between VCI or MCI and perinatal outcomes in twin pregnancies have yet to be systematically evaluated. This study aimed to investigate the relationships between VCI or MCI and perinatal outcomes, neonatal outcomes in twin pregnancies.
Methods
This was a retrospective single-center cohort study that included women with twin pregnancies and gave birth in a tertiary hospital in Southwest, China between January 2017 and December 2022. VCI and MCI were identified by abdominal ultrasound and checked after placenta delivery. Logistic regression models, multinomial logit regression models and generalized estimation equation models were used to evaluated the association between VCI or MCI and perinatal outcomes.
Results
3682 twin pregnancies were included, 100 (2.7%) pregnancies with VCI and 149 (4.0%) pregnancies with MCI. Compared to pregnancies with normal cord insertion, pregnancies with VCI were associated with an increased risk of preterm delivery 32–34 weeks both in monochorionic twins (aRRR 2.94, 95% CI 1.03–8.39) and dichorionic twins (aRRR 2.55, 95% CI 1.19–5.46), while pregnancies with MCI were not associated with preterm delivery. Pregnancies with VCI were associated with higher incidence of placental previa (aOR 6.36, 95% CI 1.92–21.04) in monochorionic twins and placental accreta in dichorionic twins (aOR 1.85, 95% CI 1.06–3.23). Pregnancies with MCI were associated with increased risk of preeclampsia (aOR 3.07, 95% CI 1.49–6.32), intertwin birthweight discordance ≥ 20% (aOR 2.40, 95% CI 1.08–5.60) and selective fetal growth restriction (aOR 2.46, 95% CI 1.08–5.60) in monochorionic twins and small-for-gestational age neonates (aOR 1.97, 95% CI 1.24–3.14) in dichorionic twins.
Conclusions
Twin pregnancies with VCI were associated with an increased risk of preterm delivery irrespective of chorionicity, whereas twin pregnancies with MCI were associated with an increased risk of preeclampsia, significant intertwin birthweight discordance in monochorionic twins and small-for-gestational age neonates in dichorionic twins.
Research on Capability Maturity Evaluation of Pharmacy Intravenous Admixture Services using Pharmacy Intravenous Admixture Services Data Reporting and Analysis Platform
Authors: Tian Shaowu , Xie Genyu , Xu Fan , Zhang Jun
Published: July 2023

Purpose: To enhance the capabilities of Pharmacy Intravenous Admixture Services (PIVAS) in ensuring the safety and appropriate utilization of intravenous medications in medical institutions.
Methods: The Regional Pharmacy Intravenous Admixture Services Data Reporting and Analysis Platform (RPDRAP) was established in 2018. This platform comprises a data collection system and a data analysis system. The data collection system consists of 67 data items and utilizes network-based data collection. The collected data were analyzed using a model with 20 indicators within the data analysis system. Fifteen PIVAS participated in the platform's application evaluation.
Results: The study revealed significant differences in PIVAS total score, supervisors, and workload between 2020 and 2022. The platform's application results demonstrated improvements in personnel management, work efficiency, and infection control within these PIVAS. Although statistical significance was observed in only 8 out of the 25 items, most of the scores showed an increase, with a small portion remaining unchanged and no decline in scores.
Conclusions: This platform can be recommended for PIVAS homogeneous and regional efficient management. The use of this platform not only improves the quality control ability of PIVAS but also enables the management department to quickly grasp the current situation and characteristics of each PIVAS through standardized data collection and analysis.
Understanding Lactation Policies and Resources Across a University System: Survey & Document Review
Authors: Loedding Emily H. , Donepudi Sritha , Padilla Heather M.
Published: July 2023

Background
Add a sentence here about breastfeeding – establishing problem. In the U.S., working women often return to work within 8–12 weeks of giving birth, therefore, it is critical that workplaces provide support for female employees combining breastfeeding and work. The Affordable Care Act requires any organization with more than 50 employees to provide a space other than a restroom for women to express breastmilk and a reasonable amount of time during the workday for women to express breastmilk. States and worksites differ in the implementation of ACA requirements and may or may not provide additional supports for female employees combining breastfeeding and work. The purpose of this study was to conduct an analysis of 26 institutions within a state university system to evaluate the differences in breastfeeding policies and resources available on each campus.
Methods
Survey data was collected from well-being liaisons in the human resources departments at each institution. In addition, we conducted a document review of policies and online materials at each institution. We used univariate statistics to summarize survey results while a thematic analysis was used to analyze institutional resources available on websites and in policies provided by the liaisons.
Results
A total of 18 (65.3%) liaisons participated in the study and revealed an overall lack of familiarity with the policies in place and inconsistencies in the resources offered to breastfeeding employees across the university system. Only half of the participating liaisons reported a formal breastfeeding policy was in place on their campus. From the document review six major themes were identified: placing the burden on female employees, describing pregnancy or postpartum as “disability,” having a university specific policy, inclusion of break times for breastfeeding, supervisor responsibility, and information on lactation policies.
Conclusion
The review of each institutions online resources confirmed the survey findings and highlighted the burden placed on female employees to discover the available resources and advocate for their needs. This paper provides insight into how institutions support breastfeeding employees and provides implications on strategies to develop policies at universities to improve breastfeeding access for working mothers.
Analysis of Proton Radiation-induced Effects on Polymer-based Relative Humidity Sensor
Authors: Kapić Amar , Tsirou Andromachi , Verdini Piero Giorgio , Carrara Sandro
Published: July 2023

Cooling at subzero temperatures and the subsequent monitoring of humidity in the modern Si-based high-energy physics detectors are indispensable but challenging due to space, radiation and magnetic field issues. In this study, a group of relative humidity sensors have been tested for operation reaching high irradiation doses adequate to the inner sub-detectors during the HL-LHC operation. The sensors were exposed to the 24 GeV/s proton beam for a period of 33 days reaching the fluence of 3 x 1016 protons/cm2. The test has demonstrated sensors radiation tolerance at high doses and their ability to provide valid alerts to the detector control and safety systems in the event of any changes in humidity.
The irradiation was conducted in a temperature- and humidity-controlled environment. Tested samples were placed in a specially designed cold box able to guarantee an ambient temperature of -20 oC. Throughout the entire test, the compressed dry air was used to keep low humidity levels (around 0 %rh) inside the cold box, and a 100 ppm pre-calibrated gas mixture was used to test the sensors responsiveness before and after the irradiation process. Additionally, an on-purpose designed signal conditioning unit was used to compensate for the cable parasitic effects.
Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation
Authors: Zhang Jingxue , Yan Xuejing , Wu Shen , Liu Qian , Cheng Ying , Teng Yufei , Ren Tianmin , Wang Ningli
Published: July 2023

Glaucoma is a highly heritable disease and myocilin was the first identified causal gene and most common pathogenic gene in glaucoma. Serine to proline mutation at position 341 of myocilin (MYOCS341P) is associated with severe glaucoma phenotypes in a five generation of primary open angle glaucoma family. But the underlying mechanisms is under explored. Here, we established MYOCS341P transgenic mouse model and characterized the glaucoma phenotypes. Further, we systematically explored the differences in function between wild-type and MYOCS341P by immunoprecipitation followed by mass spectrometry and RNA-seq analyses. We found that MYOCS341P transgenic mouse exhibit glaucoma phenotypes, characterized by reduced aqueous humor outflow, elevated intraocular pressure, decreased trabecular meshwork (TM) cells number, narrowed Schlemm’s canal, retinal ganglion cell loss, and visual impairment. Mechanistically, secretion incompetent MYOCS341P accumulated in the endoplasmic reticulum (ER), induced ER stress, and causes deregulation of autophagy, thereby promoting TM cell death. We describe an effective transgenic model for mechanistic studies and screening of therapeutic targets. And our data generated from high-throughput analyses help to elucidate the mechanism underlying mutant MYOC-related glaucoma.
Pearl farming micro-nanoplastics affect both oyster physiology and pearl quality
Authors: Gardon Tony , Luyer Jérémy Le , Moullac Gilles Le , Soyez Claude , Lagarde Fabienne , Dehaut Alexandre , Paul-Pont Ika , Huvet Arnaud
Published: July 2023

The widespread contamination of pearl farming lagoons in French Polynesia by microplastics has led to questions about risks for the pearl industry. The aim of this study was to test the effects of micro-nanoplastics (MNPs) on the pearl oyster (Pinctada margaritifera) over a 5-month pearl production cycle. MNPs were produced from plastic pearl farming gear and used at concentrations that oysters may encounter in lagoons. MNP exposure led to the alteration of energy metabolism, mostly driven by a lower assimilation efficiency of microalgae, with modulation of gene expression patterns. Pearl biomineralization was also impacted by thinner aragonite crystals, with harvest marked by the presence of abnormal biomineral concretions, called keshi pearls. These experimental results demonstrated that MNPs threaten pearl oyster biology, with potential detrimental effects on pearl quality. Ecological approaches are now required to test the holistic impact of MNPs on population maintenance and sustainability in the Polynesian pearl industry in the context of the exposome and global change.
Teaser
Exposure to pearl farming micro-nanoplastics impact oyster metabolism and harvest quality over a 5-month pearl production cycle.