bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Sugarcane Juice as a Natural Admixture on Setting Time and Hardened Properties of Cementitious Materials
Authors: Paul Suvash Chandra , Babafemi Adewumi John , Miah Md Jihad , Basit Md Abdul , Hasan Noor Md. Sadiqul , Kong Sih Ying
Published: October 2022

Admixtures are an integral part of modern cementitious materials, as they significantly enhance the rheological, mechanical, and durability properties of the material. Though manufactured admixtures are mainly used in concrete production, they are expensive. Therefore, this research investigated the effect of sugarcane juice (SCJ), as a natural admixture, on the properties of concrete. Various percentages of SCJs were used to investigate the initial and final setting time, workability, compressive strength, and splitting tensile strength of concrete. Furthermore, the effect of different cement-sand ratios (c/s) and water-cement ratios (w/c) on the setting time of different cement mortar mixes was studied. Experimental results have shown that the setting time measured by the Vicat’s apparatus reduces significantly, up to a certain percentage of SCJ in the mortar mixes. Setting time is also reduced as the c/s and w/c ratios are reduced in the mortar mix. From the results, it was found that, based on the c/s ratio, with the addition of 20% SCJ in the mix, the initial setting time of mortar can be reduced to 10% from 79%. In the case of mechanical strength, compared to the control mix (0% SCJ), more than 29% higher compressive strength in concrete was achieved by adding 10% SCJ to the mix. For the splitting strength, this increment was more than 4%. The ANOVA analysis also proved that the higher percentages of SCJ produced a compressive strength that was not statistically different from the control concrete mix. Finally, the research outcome showed that the dosages of SCJ can greatly alter the setting time and mechanical strength of cementitious materials.
Community of Bark and Ambrosia Beetles (Coleoptera: Curculionidae: Scolytinae and Platypodinae) in Agricultural and Forest Ecosystems with Laurel Wilt
Authors: Cloonan Kevin R. , Montgomery Wayne S. , Narvaez Teresa I. , Carrillo Daniel , Kendra Paul E.
Published: October 2022

Redbay ambrosia beetle, Xyleborus glabratus, is an invasive wood-boring pest first detected in the USA in 2002 in Georgia. The beetle’s dominant fungal symbiont, Harringtonialauricola, causes laurel wilt, a lethal disease of trees in the Lauraceae. Over the past 20 years, X. glabratus and laurel wilt have spread to twelve southeastern states, resulting in high mortality of native Persea species, including redbay (P. borbonia), swampbay (P. palustris), and silkbay (P. humilis). Laurel wilt also threatens avocado (P. americana) in south Florida, but in contrast to the situation in forests, X. glabratus is detected at very low levels in affected groves. Moreover, other species of ambrosia beetle have acquired H. lauricola and now function as secondary vectors. To better understand the beetle communities in different ecosystems exhibiting laurel wilt, parallel field tests were conducted in an avocado grove in Miami-Dade County and a swampbay forest in Highlands County, FL. Sampling utilized ethanol lures (the best general attractant for ambrosia beetles) and essential oil lures (the best attractants for X. glabratus), alone and in combination, resulting in detection of 20 species. This study documents host-related differences in beetle diversity and population levels, and species-specific differences in chemical ecology, as reflected in efficacy of lures and lure combinations.
Development of a Human Motion Analysis System Based on Sensorized Insoles and Machine Learning Algorithms for Gait Evaluation
Authors: Nascimento Diego Henrique Antunes , Magalhães Fabrício Anicio , Sabino George Schayer , Resende Renan Alves , Duarte Maria Lúcia Machado , Vimieiro Claysson Bruno Santos
Published: October 2022

Human gait analysis can provide an excellent source for identifying and predicting pathologies and injuries. In this respect, sensorized insoles also have a great potential for extracting gait information. This, combined with mathematical techniques based on machine learning (ML), can potentialize biomechanical analyses. The present study proposes a proof-of-concept of a system based on vertical ground reaction force (vGRF) acquisition with a sensorized insole that uses an ML algorithm to identify different patterns of vGRF and extract biomechanical characteristics that can help during clinical evaluation. The acquired data from the system was clustered by an immunological algorithm (IA) based on vGRF during gait. These clusters underwent a data mining process using the classification and regression tree algorithm (CART), where the main characteristics of each group were extracted, and some rules for gait classification were created. As a result, the system proposed was able to collect and process the biomechanical behavior of gait. After the application of IA and CART algorithms, six groups were found. The characteristics of each of these groups were extracted and verified the capability of the system to collect and process the biomechanical behavior of gait, offering verification points that can help focus during a clinical evaluation.
Assessment of Indicators of Left Ventricular Performance Obtained by Tissue Doppler Imaging in Prematurely Born Neonates
Authors: Barišić Nenad
Published: October 2022

Introduction: Tissue Doppler imaging techniques (pulsed-wave TDI (pwTDI) and color-coded TDI (cTDI)) allow for the assessment of myocardial performance during the cardiac cycle. The application of such techniques in neonatology is sporadic and poorly studied. Objective: The objective of the present study was to determine average values of pwTDI indicators of left ventricular performance (maximum systolic velocity of the mitral annulus (s’), maximum velocity in early diastole (e’) and maximum velocity in late diastole (a’)) and to examine their dynamics in prematurely born newborns in the first week of life. Methods: Prematurely born newborns of postnatal age up to 7 days were divided by gestational age into Group1 (<28 weeks) and Group 2 (≥28 weeks). Standard pwTDI parameters (s’, e’ and a’) were measured, compared between the groups and correlated with gestational and postnatal age, as well as application of respiratory support. Results: Fifty subjects were included (Group 1: 24; Group 2: 26). Average values of parameters s’, e’ and a’ were: Group 1: 4.06 ± 0.78 cm/s, 3.71 ± 0.40 cm/s and 3.98 ± 1.06 cm/s, respectively; Group 2: 4.18 ± 1.22 cm/s, 4.68 ± 1.04 cm/s and 4.12 ± 0.94 cm/s, respectively. Values of parameter e’ differed significantly between groups (p = 0.001) and strongly correlated with gestational age (p = 0, Pearson’s R = 0.88). There was no significant difference between groups for parameters s’ and a’ (p = 0.42 and 0.31, respectively). The values of s’, e’ and a’ did not differ between patients with an without respiratory support. Conclusion: Parameter e’ depends on gestational age, whereas parameters s’ and a’ are independent of gestational age. pwTDI indicators do not change during the first week of life, nor are all robust to hemodynamic circumstances caused by invasive/non-invasive respiratory support.
Stroke, Seizures, Hallucinations and Postoperative Delirium as Neurological Complications after Cardiac Surgery and Percutaneous Valve Replacement
Authors: Teller Johannes , Gabriel Maria Magdalena , Schimmelpfennig Svea-Dorothee , Laser Hans , Lichtinghagen Ralf , Schäfer Andreas , Fegbeutel Christine , Weissenborn Karin , Jung Carolin , Hinken Lukas , Worthmann Hans
Published: October 2022

(1) Background: Neurological complications such as acute ischemic stroke or postoperative delirium are frequent after cardiac surgery or percutaneous valve replacement. This study aimed to identify corresponding risk factors. (2) Methods: 297 patients with percutaneous valve replacement or cardiac surgery were postoperatively screened for neurological complications such as delirium, stroke, seizures and hallucinations twice daily for three days. Pre- and perioperative risk factors were evaluated in a multivariate model. (3) Results: Neurological complications occurred in 43.8% (n = 130) as composed of delirium (43.43%, n = 129), stroke (2.7%, n = 8), seizures (1.35%, n = 4) and real hallucinations (3.36%, n = 10). Multiple logistic regression revealed an association of neurological complications with lower Montreal Cognitive Assessment scores (Exp(B) 2.042; 95% CI, 1.183–3.525, p = 0.010), older age (Exp(B) 1.071; 95% CI, 1.036–1.107, p < 0.001), red blood cell transfusions until postoperative day 3 (Exp(B) 1.157; 95% CI, 1.030–1.300, p = 0.014), history of heart failure (Exp(B) 1.985; 95% CI, 1.130–3.487, p = 0.017) and increased CRP levels (Exp(B) 1.004; 95% CI, 1.000–1.008, p = 0.037). (4) Conclusions: Postoperative delirium remains a frequent complication after cardiac surgery, while stroke and seizures occur rarely. A preoperative risk profile including older age, history of heart failure and cognitive impairment was identified for a complicated postoperative course. However, the impact of an intense inflammatory response must not be neglected.
Caspase-1 Inhibition Reduces Occurrence of PANoptosis in Macrophages Infected by E. faecalis OG1RF
Authors: Chi Danlu , Zhang Yuejiao , Lin Xinwei , Gong Qimei , Tong Zhongchun
Published: October 2022

To investigate the effect of caspase-1 inhibition on PANoptosis in macrophages infected with Enterococcus faecalis OG1RF. RAW264.7 cells with and without pretreatment by caspase-1 inhibitor were infected with E. faecalis OG1RF at multiplicities of infection (MOIs). A live cell imaging analysis system and Western blot were applied to evaluate the dynamic curve of cell death and the expression of executor proteins of PANoptosis. The mRNA expression of IL-1β and IL-18 was quantified by RT-qPCR. Morphological changes were observed under scanning electron microscopy. We found that PI-positive cells emerged earlier and peaked at a faster rate in E. faecalis-infected macrophages (Ef-MPs) at higher MOIs. The expression of the N-terminal domain of the effector protein gasdermin D (GSDMD-N), cleaved caspase-3 and pMLKL were significantly upregulated at MOIs of 10:1 at 6 h and at MOI of 1:1 at 12 h postinfection. In Ef-MPs pretreated with caspase-1 inhibitor, the number of PI-positive cells was significantly reduced, and the expression of IL-1β and IL-18 genes and cleaved caspase-1/-3 and GSDMD-N proteins was significantly downregulated (p < 0.05), while pMLKL was still markedly increased (p < 0.05). Ef-MPs remained relatively intact with caspase-1 inhibitor. In conclusion, E. faecalis induced cell death in macrophages in an MOI-dependent manner. Caspase-1 inhibitor simultaneously inhibited pyroptosis and apoptosis in Ef-MPs, but necroptosis still occurred.
Efficacy of Dupilumab on Different Phenotypes of Adult with Moderate-to-Severe Atopic Dermatitis in Taiwan: A Real-World Study
Authors: Yang Chin-Yi , Lai Po-Ju , Chen Chun-Bing , Chan Tom C. , Hui Rosaline Chung-Yee , Huang Yu-Huei , Tseng Han-Chi , Lin Shang-Hung , Lu Chun-Wei , Lee Hua-En , Lin Jing-Yi , Chi Min-Hui , Tsai Ming-Feng , Hwang Yih-Shiou , Wang Chuang-Wei , Chu Chia-Yu , Chung Wen-Hung
Published: October 2022

To determine phenotype-related dupilumab response in adult patients with atopic dermatitis (AD), this multicenter, retrospective study included 111 adults with moderate-to-severe AD in Taiwan, with median age of 31.5 years (18–87) and 71 (64.0%) males. Patients received dupilumab 300 mg per two to three weeks up to 12 months. We found a significant improvement after 4 and 16 weeks of treatment in all patients for all the assessed scores, including eczema area and severity index (EASI) improvement ≥50% (EASI-50) and 75% (EASI-75), EASI reaching minimal clinically important difference (MCID), and Investigator’s Global Assessment (IGA) improvement ≥2. Importantly, prior to asthma, early AD onset and 3-week drug intervals were significantly associated with a high proportion of EASI-75 at month 12, while prurigo and lichenoid phenotypes were associated with a lower proportion of EASI-75 at month 12. However, the majority of adverse events were mild in severity. In conclusion, our study results identify phenotype-related dupilumab response at month 12 in adults with moderate-to-severe AD, and we suggest that treatment should not be discontinued until reaching a satisfactory clinical response.
Factors Influencing the Survival Rate of Teeth and Implants in Patients after Tumor Therapy to the Head and Neck Region—Part 1: Tooth Survival
Authors: Schweyen Ramona , Reich Waldemar , Vordermark Dirk , Kuhnt Thomas , Wienke Andreas , Hey Jeremias
Published: October 2022

We aimed to evaluate possible factors influencing the long-term survival of teeth after tumor therapy (TT) to the head and neck region with and without radiation. Between January 2019 and January 2020, patients who underwent TT for head and neck cancer and received dental treatment before and after TT at the Department of Prosthetic Dentistry of the Martin Luther University Halle-Wittenberg were enrolled in the study. Clinical examination with assessment of dental status and stimulated salivary flow rate (SFR) was performed and information about disease progression and therapy was retrieved from medical records. Of 118 patients (male: 70.3%; mean age: 63.2 ± 12.4 years), 95 received radiotherapy (RT), and 47 were administered radio-chemotherapy (RCT). The teeth of irradiated patients exhibited a lower 5-year survival probability (74.2%) than those of non-irradiated patients (89.4%). The risk of loss (RL) after RT increased with nicotine use, presence of intraoral defects, reduced SFR, RCT and regarding mandibular teeth, and decreased with crowning following TT. Lower SFR increased the RL even without RT. Consideration of patient’s treatment history, individual risk profile, and clinical findings during the prosthetic planning phase could enable earlier, more targeted dental treatment after TT (e.g., timely crowning).
Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review
Authors: Ferrillo Martina , Lippi Lorenzo , Giudice Amerigo , Calafiore Dario , Paolucci Teresa , Renò Filippo , Migliario Mario , Fortunato Leonzio , Invernizzi Marco , Sire Alessandro
Published: October 2022

Although a growing body of literature has been emphasizing the role of vitamin D in oral health, there is still a gap of knowledge regarding the correlation between temporomandibular disorders (TMDs) and vitamin D. Therefore, the aim of this systematic review was to assess the linkage between hypovitaminosis D and TMDs to map the current literature in this field. On 10 September 2022, PubMed, Scopus, and Web of Science databases were systematically searched from the date of their inception to identify the studies that had assessed patients with TMDs. The primary outcome assessed in this review was the relationship between hypovitaminosis D and TMDs. Out of the 329 studies identified, 13 studies met the eligibility criteria and were included in the present work. Seven studies assessed the relationship between vitamin D and TMDs, reporting that vitamin D serum levels are lower in patients with TMDs. Our results suggested that vitamin D receptor (VDR) polymorphisms might have a role in TMDs’ development. However, the quality assessed underlined that only one study did not present a serious risk of bias. Further good-quality studies are needed to clarify the linkage between vitamin D deficiency and TMDs, but the evidence currently available has suggested potential correlations.
Comparison of Microbial Sampling Sites and Donor-Related Factors on Corneal Graft Contamination
Authors: Wang Yu-Jen , Sung Ko-Chiang , Lin Wei-Chen , Huang Fu-Chin
Published: October 2022

Grafts used for corneal donation should be sterile to avoid transplantation failure and secondary infection. However, there are no clear and globally accepted specifications from eye banks on microbial sampling sites. The objective of this study was to analyze microbial contamination of corneal grafts collected from different sampling sites. We found that the contamination rates and strain compositions significantly differed at different sampling sites. To clarify the effect of the microbial sampling site on corneal graft contamination, microbial sampling was conducted using 30 corneal grafts at the extraocular and intraocular sides of the graft in 2020 from the National Eye Bank of Taiwan. Microbial contamination significantly differed (p < 0.05) between the different sampling sites on the graft according to McNemar’s test. Although the two sampling sites showed the same specificity (33.33%), the sensitivity of sampling on the extraocular side (82.35%) was higher than that on the intraocular side (17.65%) of the graft. Donor-associated factors, including the cause of death, operating place, and cold compression, were analyzed using chi-square statistics, which revealed no significant differences in microbial contamination. Thus, our data provide evidence for the microbial sampling site of donated grafts and clear specifications for maintaining the quality of corneal grafts.
Respiratory Physiology of COVID-19 and Influenza Associated Acute Respiratory Distress Syndrome
Authors: Kronibus Niklas , Seiler Frederik , Danziger Guy , Muellenbach Ralf , Reyher Christian , Becker André , Kamphorst Maren , Rixecker Torben , Metz Carlos , Bals Robert , Lepper Philipp , Mang Sebastian
Published: October 2022

Background: There is ongoing debate whether lung physiology of COVID-19-associated acute respiratory distress syndrome (ARDS) differs from ARDS of other origin. Objective: The aim of this study was to analyze and compare how critically ill patients with COVID-19 and Influenza A or B were ventilated in our tertiary care center with or without extracorporeal membrane oxygenation (ECMO). We ask if acute lung failure due to COVID-19 requires different intensive care management compared to conventional ARDS. Methods: 25 patients with COVID-19-associated ARDS were matched to a cohort of 25 Influenza patients treated in our center from 2011 to 2021. Subgroup analysis addressed whether patients on ECMO received different mechanical ventilation than patients without extracorporeal support. Results: Compared to Influenza-associated ARDS, COVID-19 patients had higher ventilatory system compliance (40.7 mL/mbar [31.8–46.7 mL/mbar] vs. 31.4 mL/mbar [13.7–42.8 mL/mbar], p = 0.198), higher ventilatory ratio (1.57 [1.31–1.84] vs. 0.91 [0.44–1.38], p = 0.006) and higher minute ventilation at the time of intubation (mean minute ventilation 10.7 L/min [7.2–12.2 L/min] for COVID-19 vs. 6.0 L/min [2.5–10.1 L/min] for Influenza, p = 0.013). There were no measurable differences in P/F ratio, positive end-expiratory pressure (PEEP) and driving pressures (ΔP). Respiratory system compliance deteriorated considerably in COVID-19 patients on ECMO during 2 weeks of mechanical ventilation (Crs, mean decrease over 2 weeks −23.87 mL/mbar ± 32.94 mL/mbar, p = 0.037) but not in ventilated Influenza patients on ECMO and less so in ventilated COVID-19 patients without ECMO. For COVID-19 patients, low driving pressures on ECMO were strongly correlated to a decline in compliance after 2 weeks (Pearson’s R 0.80, p = 0.058). Overall mortality was insignificantly lower for COVID-19 patients compared to Influenza patients (40% vs. 48%, p = 0.31). Outcome was insignificantly worse for patients requiring veno-venous ECMO in both groups (50% mortality for COVID-19 on ECMO vs. 27% without ECMO, p = 0.30/56% vs. 34% mortality for Influenza A/B with and without ECMO, p = 0.31). Conclusion: The pathophysiology of early COVID-19-associated ARDS differs from Influenza-associated acute lung failure by sustained respiratory mechanics during the early phase of ventilation. We question whether intubated COVID-19 patients on ECMO benefit from extremely low driving pressures, as this appears to accelerate derecruitment and consecutive loss of ventilatory system compliance.
Resizing of the Gastric Pouch for Weight Regain after Laparoscopic Roux-en-Y Gastric Bypass and One-Anastomosis Gastric Bypass: Is It a Valid Option?
Authors: Ferro Silvia , Zulian Viola , De Palma Massimiliano , Sartori Andrea , Andreica Anamaria , Nedelcu Marius , Carandina Sergio
Published: October 2022

Introduction: The laparoscopic resizing of the gastric pouch (LPR) has recently been proposed as a revisional technique in the case of weight regain (WR) after gastric bypass procedures. The aim of this study was to report our experience with LPR for WR. Materials and Methods: All patients with WR ≥ 25% after gastric bypass and with a dilated gastric pouch and/or gastrojejunal anastomosis who underwent LPR between January 2017 and January 2022 were retrospectively reviewed. From a radiological point of view, a gastric pouch was considered dilated when its volume was calculated at >80 cm3 for LRYGB and >200 cm3 for OAGB upon a 3D-CT scan. The endoscopic criterion considered both the diameter of the gastrojejunal anastomosis and the gastric pouch volume. All anastomoses > 20 mm for LRYGB and >40 mm for OAGB were considered dilated, while a gastric pouch was considered endoscopically dilated when the retrovision maneuver with the gastroscope was easily performed. These selection criteria were arbitrarily established on the basis of both our personal experience and literature data. Results: Twenty-three patients had LPR after a Roux-en-Y gastric bypass or one-anastomosis gastric bypass. The mean BMI at LPR was 36.3 ± 4.7 kg/m2. All patients underwent LPR, while the resizing of the GJA was also performed in 3/23 (13%) cases, and hiatoplasty was associated with the resizing of the pouch in 6/23 cases (26.1%). The mean BMI at the last follow-up was 29.3 ± 5.8 kg/m2. The difference between the BMI before resizing and the BMI at the last follow-up visit was statistically significant (p = 0.00005). The mean %TWL at 24.2 ± 16.1 months was 19.6 ± 9%. Comorbidities had an overall resolution and/or improvement rate of 47%. The mean operative time was 71.7 ± 21.9 min. The conversion rate was nil. Postoperative complications occurred in two cases (8.7%). Conclusions: In our series, LPR for WR showed good results in weight loss and in improvement/resolution of comorbidities, with an acceptable complication rate and operative time. Only further studies with a greater cohort of patients and a longer postoperative follow-up will be able to highlight the long-term benefits of this technique.
Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial
Authors: Tsurumi Tomoki , Tamura Yuma , Nakatani Yuki , Furuya Tomoki , Tamiya Hajime , Terashima Masato , Tomoe Takashi , Ueno Asuka , Shimoyama Masahiro , Yasu Takanori
Published: October 2022

Hemodialysis patients with diabetic kidney disease (DKD) experience blood glucose fluctuations owing to insulin removal. We evaluated the effects of single and long-term application of neuromuscular electrical stimulation (NMES) during hemodialysis on glycemic control. This trial was conducted in two stages: Stage 1, following a crossover design and 4 week washout period, eleven outpatients with DKD either underwent a single bout of NMES for 30 min (NMES period) or rested (control period) after receiving nutritional support during hemodialysis; Stage 2, following a crossover design and 4 week washout period, each participant received the intervention for 12 weeks. NMES was administered for 30 min at the maximum tolerable intensity. The mean subcutaneous glucose concentration and mean amplitude of glycemic excursion (MAGE) were determined by flash glucose monitoring for 24 h. Changes in glycoalbumin and MAGE before and after NMES initiation were evaluated. The mean blood glucose level and MAGE after a single bout of NMES were significantly lower than those after rest. Glycoalbumin levels and echo intensity of the rectus femoris tended to decrease, but not significantly by ANOVA due to a lack in statistical power after the dropout of three patients. NMES in end-stage DKD decreased blood glucose levels during and after hemodialysis.
Complications and Implant Survival of Total Knee Arthroplasty in People with Hemophilia
Authors: Rodriguez-Merchan Emerito Carlos , De la Corte-Rodriguez Hortensia , Alvarez-Roman Teresa , Gomez-Cardero Primitivo , Encinas-Ullan Carlos A. , Jimenez-Yuste Victor
Published: October 2022

Total knee arthroplasty (TKA) is a commonly used option in advanced stages of knee arthropathy in people with hemophilia (PWH). The objective of this article is to determine what the complication rates and implant survival rates in PWH are in the literature. A literature search was carried out in PubMed (MEDLINE), Cochrane Library, Web of Science, Embase and Google Scholar utilizing the keywords “hemophilia TKA complications” on 20 October 2022. It was found that the rate of complications after TKA in PWH is high (range 7% to 30%), although it has improved during the last two decades, possibly due to better perioperative hematologic treatment. However, prosthetic survival at 10 years has not changed substantially, being in the last 30 years approximately 80% to 90% taking as endpoint the revision for any reason. Survival at 20 years taking as endpoint the revision for any reason is 60%. It is possible that with a precise perioperative control of hemostasis in PWH, the percentage of complications after TKA can be diminished.
Extrahepatic Manifestations of Chronic HBV Infection and the Role of Antiviral Therapy
Authors: Mazzaro Cesare , Adinolfi Luigi Elio , Pozzato Gabriele , Nevola Riccardo , Zanier Ada , Serraino Diego , Andreone Pietro , Fenoglio Roberta , Sciascia Savino , Gattei Valter , Roccatello Dario
Published: October 2022

The hepatitis B virus (HBV) infection leads to chronic hepatitis, cirrhosis, and hepatocarcinoma. However, about 20% of patients experience extrahepatic manifestations such as polyarteritis nodosa, non-rheumatoid arthritis, non-Hodgkin lymphoma, cryoglobulinemic vasculitis, and glomerulonephritis. These influence the patient’s morbidity, quality of life and mortality. The treatment of an HBV infection is based on nucleotide analogues (NAs) which are safe and effective for the suppression of HBV-DNA in almost 100% of cases. A few studies have shown that NAs induce a viral response and an improvement of extrahepatic diseases. There is a lack of a thorough analysis of the available treatments for extrahepatic HBV manifestations. In 90% to 100% of cases, the NAs stop the HBV replication, and they produce a clinical response in the majority of patients with mild to moderate extrahepatic signs/symptoms. Arthritis can definitely disappear after the HBV elimination and, in some cases, the HBV eradication following NAs therapy appears to improve the renal function in HBV-related nephropathies. Plasma exchange can be used in subjects who are suffering from the most aggressive forms of cryoglobulinemic vasculitis and glomerulonephritis, progressive peripheral neuropathy, and life-threatening cases, and this can be combined with glucocorticosteroids and antiviral agents. In selected refractory patients, the use of rituximab in conjunction with NAs therapy can be considered. The review provides an update on extrahepatic conditions that are linked to HBV and the impact of treating HBV with NAs.
Doll Therapy Intervention Reduces Challenging Behaviours of Women with Dementia Living in Nursing Homes: Results from a Randomized Single-Blind Controlled Trial
Authors: Molteni Valentina , Vaccaro Roberta , Ballabio Roberta , Ceppi Laura , Cantù Marco , Ardito Rita B. , Adenzato Mauro , Poletti Barbara , Guaita Antonio , Pezzati Rita
Published: October 2022

Background: Doll therapy (DT) is a non-pharmacological intervention for the treatment of the behavioural and psychological symptoms of dementia (BPSD). We designed a single-blind randomized controlled trial of the 30-day efficacy of DT in reducing the BPSD, professional caregivers’ distress and patients’ biomarkers of stress, and in improving the exploration and caregiving behaviours. Methods: We randomly assigned 134 women with moderate-to-severe dementia living in nursing homes (NHs) to a DT intervention (DTI, 67) or a sham intervention with a cube (SI, 67). Results: From the first to the 30th session, the DTI group showed a significant decrease in the Neuropsychiatric Inventory-NH (NPI-NH) total score and in the NPI-NH-Distress score compared to the SI group (both p < 0.001). We observed a greater interest in the doll than in the cube, a greater acceptance of a separation from the nurse among DTI participants, and caregiving and exploratory behaviours towards the doll. There were no differences between the groups in the stress biomarkers. Conclusions: Consistent with attachment theory, our findings support the 30-day efficacy of DT, as this non-pharmacological intervention promotes perceptions of security by creating a situation in which patients feel confident and engaged in a caregiving relationship with the doll and reduces the challenging behaviours that are stressful for professional caregivers.
Association between Normal Weight Obesity and Skeletal Muscle Mass Index in Female University Students with Past Exercise Habituation
Authors: Oshita Kazushige , Myotsuzono Ryota , Tashiro Tomoki
Published: October 2022

This study investigated the relationship between normal weight obesity (NW-O) and skeletal muscle mass index (SMI) in 120 female university students who participated in sporting activities during junior and senior high school. The current physical activity level (PAL) was estimated by a factorial method using 24-h physical activity recall. The body mass index (BMI) of the participants ranged from 18.5 to 24.9 kg/m2; their body fat (BF) was classified as NW-O if above the 75th percentile (28.9% BF), normal weight and lean (NW-L) if below the 25th percentile value (21.0%BF), and all others were normal weight (NW). PAL was significantly lower in NW-O than in NW-L. SMI was significantly lower in NW-O than in NW and NW-L, and 60% of NW-O had Low-SMI (<6.3 kg/m2). Although lower limb muscle mass was significantly lower in NW-O than in NW and NW-L, no significant differences were found in the upper limbs. These results suggest that the current PAL is associated with NW-O, and NW-O is associated with a lower SMI, even in young females with past exercise habits. Therefore, the prevention of NW-O in young females is important for the prevention of not only lifestyle-related diseases, but also future sarcopenia.
Local-Sensitive Connectivity Filter (LS-CF): A Post-Processing Unsupervised Improvement of the Frangi, Hessian and Vesselness Filters for Multimodal Vessel Segmentation
Authors: Rodrigues Erick O. , Rodrigues Lucas O. , Machado João H. P. , Casanova Dalcimar , Teixeira Marcelo , Oliva Jeferson T. , Bernardes Giovani , Liatsis Panos
Published: October 2022

A retinal vessel analysis is a procedure that can be used as an assessment of risks to the eye. This work proposes an unsupervised multimodal approach that improves the response of the Frangi filter, enabling automatic vessel segmentation. We propose a filter that computes pixel-level vessel continuity while introducing a local tolerance heuristic to fill in vessel discontinuities produced by the Frangi response. This proposal, called the local-sensitive connectivity filter (LS-CF), is compared against a naive connectivity filter to the baseline thresholded Frangi filter response and to the naive connectivity filter response in combination with the morphological closing and to the current approaches in the literature. The proposal was able to achieve competitive results in a variety of multimodal datasets. It was robust enough to outperform all the state-of-the-art approaches in the literature for the OSIRIX angiographic dataset in terms of accuracy and 4 out of 5 works in the case of the IOSTAR dataset while also outperforming several works in the case of the DRIVE and STARE datasets and 6 out of 10 in the CHASE-DB dataset. For the CHASE-DB, it also outperformed all the state-of-the-art unsupervised methods.
Online Calibration of a Linear Micro Tomosynthesis Scanner
Authors: Bahar Piroz , Nguyen David , Wang Muyang , Mazilu Dumitru , Bennett Eric E. , Wen Han
Published: October 2022

In a linear tomosynthesis scanner designed for imaging histologic samples of several centimeters size at 10 µm resolution, the mechanical instability of the scanning stage (±10 µm) exceeded the resolution of the image system, making it necessary to determine the trajectory of the stage for each scan to avoid blurring and artifacts in the images that would arise from the errors in the geometric information used in 3D reconstruction. We present a method for online calibration by attaching a layer of randomly dispersed micro glass beads or calcium particles to the bottom of the sample stage. The method was based on a parametric representation of the rigid body motion of the sample stage-marker layer assembly. The marker layer was easy to produce and proven effective in the calibration procedure.
CNN-Based Classification for Highly Similar Vehicle Model Using Multi-Task Learning
Authors: Avianto Donny , Harjoko Agus , Afiahayati
Published: October 2022

Vehicle make and model classification is crucial to the operation of an intelligent transportation system (ITS). Fine-grained vehicle information such as make and model can help officers uncover cases of traffic violations when license plate information cannot be obtained. Various techniques have been developed to perform vehicle make and model classification. However, it is very hard to identify the make and model of vehicles with highly similar visual appearances. The classifier contains a lot of potential for mistakes because the vehicles look very similar but have different models and manufacturers. To solve this problem, a fine-grained classifier based on convolutional neural networks with a multi-task learning approach is proposed in this paper. The proposed method takes a vehicle image as input and extracts features using the VGG-16 architecture. The extracted features will then be sent to two different branches, with one branch being used to classify the vehicle model and the other to classify the vehicle make. The performance of the proposed method was evaluated using the InaV-Dash dataset, which contains an Indonesian vehicle model with a highly similar visual appearance. The experimental results show that the proposed method achieves 98.73% accuracy for vehicle make and 97.69% accuracy for vehicle model. Our study also demonstrates that the proposed method is able to improve the performance of the baseline method on highly similar vehicle classification problems.
Hybrid of Deep Learning and Word Embedding in Generating Captions: Image-Captioning Solution for Geological Rock Images
Authors: Nursikuwagus Agus , Munir Rinaldi , Khodra Masayu Leylia
Published: October 2022

Captioning is the process of assembling a description for an image. Previous research on captioning has usually focused on foreground objects. In captioning concepts, there are two main objects for discussion: background object and foreground object. In contrast to the previous image-captioning research, generating captions from the geological images of rocks is more focused on the background of the images. This study proposed image captioning using a convolutional neural network, long short-term memory, and word2vec to generate words from the image. The proposed model was constructed by a convolutional neural network (CNN), long short-term memory (LSTM), and word2vec and gave a dense output of 256 units. To make it properly grammatical, a sequence of predicted words was reconstructed into a sentence by the beam search algorithm with K = 3. An evaluation of the pre-trained baseline model VGG16 and our proposed CNN-A, CNN-B, CNN-C, and CNN-D models used BLEU score methods for the N-gram. The BLEU scores achieved for BLEU-1 using these models were 0.5515, 0.6463, 0.7012, 0.7620, and 0.5620, respectively. BLEU-2 showed scores of 0.6048, 0.6507, 0.7083, 0.8756, and 0.6578, respectively. BLEU-3 performed with scores of 0.6414, 0.6892, 0.7312, 0.8861, and 0.7307, respectively. Finally, BLEU-4 had scores of 0.6526, 0.6504, 0.7345, 0.8250, and 0.7537, respectively. Our CNN-C model outperformed the other models, especially the baseline model. Furthermore, there are several future challenges in studying captions, such as geological sentence structure, geological sentence phrase, and constructing words by a geological tagger.
Teachers’ Perceptions of Changes in Their Professional Development as a Result of ICT
Authors: Negrín-Medina Miguel Ángel , Bernárdez-Gómez Abraham , Portela-Pruaño Antonio , Marrero-Galván Juan José
Published: October 2022

The introduction of digital information and communication technologies has influenced many aspects of the teaching profession. In addition to their changing use in the classroom, these technologies have strongly impacted the work and professional development of teachers. In this study, which was framed within the R+D+i project DePrInEd, we analyzed the perceptions, beliefs, opinions, and attitudes of teachers on this subject. We conducted a qualitative study through interviews, with a thematic analysis addressing the duality of technology and change. The results indicated that these produced benefits and created difficulties in the teaching task, with the latter being more demanding. Teachers stated that one of the main difficulties they encountered was related to the evolution of students as a result of technology, both in the school and social contexts. This highlights the risk that its extensive use did not lead to the acquisition of other key competencies, including digital and media competencies, in the school environment. Finally, other dimensions that impacted the corporate intelligence of educational centers included the continuous adaptation and mastery of digital competence required by teachers regarding the changes in their tasks, as well as the excessive bureaucratization that technologies have necessitated.
Direct Digital Manufacturing of a Customized Face Mask
Authors: Bilalis Leonardos , Canellidis Vassilios , Papatheodorou Theodore , Giannatsis John
Published: October 2022

Direct Digital Manufacturing (DDM) is considered by many as one of the most promising approaches towards cost- and time-efficient mass customization. Compared to conventional manufacturing systems, DDM systems are not as common and incorporate several distinctive features, such as higher flexibility in product form and structure, lower economies of scale and higher potential for decentralized production network. The initial design phase of a DDM production system, where very important in term of efficiency and quality, decisions are made, is a relatively unexplored topic in the relevant literature. In the present study, the corresponding issues are investigated through a case study involving the direct digital production of a customized reusable face mask (respirator) for medical use. Investigated system design aspects include product, process, and facility design. Based on data generated through manufacturing tests, a preliminary cost analysis is performed and several scenarios regarding production throughput and facility planning are examined. According to the results, DDM of custom-made face masks is, to a large extent, technically and economically feasible. Interestingly, considering the whole process, a large part of production cost is associated with labor and materials. Finally, evidence for a fundamental trade-off between manufacturing cost and speed/flexibility is identified, implying that different implementations of DDM systems can be realized depending on strategic operational objectives.
Nature-Inspired Design and Advanced Multi-Computational Investigations on the Mission Profile of a Highly Manoeuvrable Unmanned Amphibious Vehicle for Ravage Removals in Various Oceanic Environments
Authors: Raja Vijayanandh , Madasamy Senthil Kumar , Rajendran Parvathy , Ganesan Sangeetha , Murugan Dharshini , A. Z. AL-bonsrulah Hussein , Al-Bahrani Mohammed
Published: October 2022

Recent large-scale operations, including frequent maritime transportation and unauthorised as well as unlawful collisions of drainage wastes, have polluted the ocean’s ecology. Due to the ocean’s unsuitable ecology, the entire globe may experience drastic aberrant conditions, which will force illness onto all living things. Therefore, an advanced system is very necessary to remove the undesired waste from the ocean’s surface and interior. Through the use of progressive unmanned amphibious vehicles (UAV), this study provides a dynamic operational mode-based solution to damage removal. In order to successfully handle the heavy payloads of ravage collections when the UAV reveals centre of gravity concerns, a highly manoeuvrable-based design inspired by nature has been imposed. The ideal creatures to serve as the inspiration for this piece are tropical birds, which have a long tail for navigating tricky situations. The design initialization was carried out by focusing on the outer body of tropical birds. Following this, special calculations were conducted and the full design parameters of the UAV were established. This study proposes a unique mathematical formulation for the development of primary and secondary design parameters of an UAV. The proposed mission profile of this application is computationally tested with the aid of sophisticated computational methodologies after the modelling of this UAV. The computational methods that are required are one-way coupling-based hydro-structural interaction assessments and computational hydrodynamic analyses. Computing is used to determine the aerodynamic and hydrodynamic forces over the UAV, the lightweight materials to withstand high fluid dynamic loads, and the buoyancy forces to complete the UAV components. These computational methods have been used to produce a flexible and fine-tuned UAV design for targeted real-time applications.
Design and Research of Slope-Pendulum Wave Energy Conversion Device
Authors: Wan Zhanhong , Li Ze , Zhang Dahai , Zheng Honghao
Published: October 2022

Wave energy is a kind of clean energy that is rich in reserves and has not been exploited on a large scale. The slope-pendulum wave energy conversion (S-PWEC) device has been optimized in structure and its capture efficiency has been increased. Taking the selection of the Zhejiang sea area as the research background, this paper performs numerical simulation and array WEC experimental testing of S-PWEC under 66 major sea conditions. The experimental results show that S-PWEC adds a slope structure to the bottom, which can effectively improve the motion response ability and resistance to extreme sea conditions. In the regular wave and irregular wave tests, the electron power output efficiency can be increased by 13.24% and 10.06%, respectively; in the array WEC experiment, the diffraction effect and radiation effect will affect the work of the array WEC, and the optimal arrangement distance can be selected to maximize the power output of the WEC system.
Roles of BrlA and AbaA in Mediating Asexual and Insect Pathogenic Lifecycles of Metarhizium robertsii
Authors: Zhang Jin-Guan , Xu Si-Yuan , Ying Sheng-Hua , Feng Ming-Guang
Published: October 2022

BrlA and AbaA are key activators of the central developmental pathway (CDP) that controls asexual development in Aspergillus but their roles remain insufficiently understood in hypocerealean insect pathogens. Here, regulatory roles of BrlA and AbaA orthologs in Metarhizium robertsii (Clavicipitaceae) were characterized for comparison to those elucidated previously in Beauveria bassiana (Cordycipitaceae) at phenotypic and transcriptomic levels. Time-course transcription profiles of brlA, abaA, and the other CDP activator gene wetA revealed that they were not so sequentially activated in M. robertsii as learned in Aspergillus. Aerial conidiation essential for fungal infection and dispersal, submerged blastospore production mimicking yeast-like budding proliferation in insect hemocoel, and insect pathogenicity via cuticular penetration were all abolished as a consequence of brlA or abaA disruption, which had little impact on normal hyphal growth. The disruptants were severely compromised in virulence via cuticle-bypassing infection (intrahemocoel injection) and differentially impaired in cellular tolerance to oxidative and cell wall-perturbing stresses. The ΔbrlA and ΔabaA mutant shad 255 and 233 dysregulated genes (up/down ratios: 52:203 and 101:122) respectively, including 108 genes co-dysregulated. These counts were small compared with 1513 and 2869 dysregulated genes (up/down ratios: 707:806 and 1513:1356) identified in ΔbrlA and ΔabaA mutants of B. bassiana. Results revealed not only conserved roles for BrlA and AbaA in asexual developmental control but also their indispensable roles in fungal adaptation to the insect-pathogenic lifecycle and host habitats. Intriguingly, BrlA- or AbaA-controlled gene expression networks are largely different between the two insect pathogens, in which similar phenotypes were compromised in the absence of either brlA or abaA.
Description of Four Novel Species in Pleosporales Associated with Coffee in Yunnan, China
Authors: Lu Li , Karunarathna Samantha C. , Dai Dong-Qin , Xiong Yin-Ru , Suwannarach Nakarin , Stephenson Steven L. , Elgorban Abdallah M. , Al-Rejaie Salim , Jayawardena Ruvishika S. , Tibpromma Saowaluck
Published: October 2022

In Yunnan Province, the coffee-growing regions are mainly distributed in Pu’er and Xishuangbanna. During the surveys of microfungi associated with coffee in Yunnan Province, seven taxa were isolated from coffee samples. Based on molecular phylogenetic analyses of combined ITS, LSU, SSU, rpb2, and tef1-α sequence data and morphological characteristics, four new species viz. Deniquelata yunnanensis, Paraconiothyrium yunnanensis, Pseudocoleophoma puerensis, and Pse. yunnanensis, and three new records viz. Austropleospora keteleeriae, Montagnula thailandica, and Xenocamarosporium acaciae in Pleosporales are introduced. In addition, Paracamarosporium fungicola was transferred back to Paraconiothyrium based on taxonomy and DNA sequences. Full descriptions, illustrations, and phylogenetic trees to show the placement of new and known taxa are provided. In addition, the morphological comparisons of new taxa with closely related taxa are given.