bluuebunny/crossref_metadata_2025 huggingface dataset:
Osimertinib in Elderly Patients with Epidermal Growth Factor Receptor T790M-Positive Non-Small-Cell Lung Cancer Who Progressed During Prior Treatment: A Phase II Trial
Authors: Nakao Akira , Hiranuma Osamu , Uchino Junji , Sakaguchi Chikara , Kita Toshiyuki , Hiraoka Noriya , Ishizuka Tamotsu , Kubota Yutaka , Kawasaki Masayuki , Goto Yasuhiro , Imai Hisao , Hattori Noboru , Nakatomi Keita , Uramoto Hidetaka , Uryu Kiyoaki , Fukuda Minoru , Uchida Yasuki , Yokoyama Toshihide , Akai Masaya , Mio Tadashi , Nagashima Seiji , Chihara Yusuke , Tamiya Nobuyo , Kaneko Yoshiko , Mouri Takako , Yamada Tadaaki , Yoshimura Kenichi , Fujita Masaki , Takayama Koichi
Published: January 2019

Lessons Learned

Non-small-cell lung cancer (NSCLC) represents 85% of lung cancer in elderly patients. In the present study performed in the 36 elderly subjects with epidermal growth factor receptor (EGFR) T790M mutation-positive NSCLC, osimertinib 80 mg demonstrated statistically significant improvement in the objective response rate, which was comparable to those in the nonelderly population. Osimertinib appears to be an effective and safe treatment option in elderly patients with advanced NSCLC with EGFR mutation; further research in larger scale is warranted.

Background

Previous findings suggest the possibility of relatively safe use of osimertinib for patients with T790M-positive non-small-cell lung cancer (NSCLC), with few serious adverse events for the elderly in comparison with conventional endothelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), and with an antitumor effect.

Methods

This phase II study was performed to prospectively investigate the efficacy and safety of osimertinib for elderly patients aged ≥75 years with ineffective prior EGFR TKI treatment or with recurrence in T790M EGFR TKI resistance mutation-positive NSCLC.

Results

A total of 36 patients were included in the analyses. Among the 36 subjects, 63.9% were female, with mean age of 79.9 years. The objective response rate (ORR) was 58.3% (95% confidence interval [CI], 42.2%–72.9%), demonstrating statistically significant efficacy of osimertinib (p = .0017). The median duration of response (DOR) was 27.9 weeks (95% CI, 21.1–82.0). Complete response (CR) and partial response (PR) were 2.8% and 55.6%, respectively. Disease control rate (DCR) was 97.2%. A waterfall plot revealed that 33 (91.6%) subjects exhibited tumor shrinkage during treatment, including 12 of 14 subjects who had stable disease (SD). All adverse events were not reason for discontinuation of the study drug.

Conclusion

Osimertinib may be an effective and safe treatment option in elderly patients with advanced NSCLC with EGFR mutation.
Effect of activator, curing and humidity on drying shrinkage of alkali-activated fly ash
Authors: Hojati Maryam , Rajabipour Farshad , Radlińska Aleksandra
Published: January 2019

Alkali-activated fly ash (AAFA) concrete is receiving considerable attention due to its environmental benefits; however, its long-term performance still requires validation and laboratory verification. This research studied the drying shrinkage of AAFA pastes as a function of activator composition (water content and n-modulus), relative humidity (RH) and heat-curing duration. Four AAFAs activated by different sodium silicate solutions and a control ordinary Portland cement (OPC) were examined. The activating solution affected the pore structure, pore solution and shrinkage characteristics of AAFAs. Use of an activator with a higher n-modulus resulted in a finer pore structure, superior mechanical properties and a larger magnitude of shrinkage. The results indicate that heat-cured AAFA paste dried faster, and its shrinkage reached equilibrium earlier compared to that of OPC. Similar to OPC, a bilinear relationship between RH and shrinkage of AAFA was observed. The results indicate that a longer steam-curing duration can stabilize the matrix of AAFAs and reduce their shrinkage.
On the relation between surface texture of metallic implants and their bioactivity
Authors: Rad Armin Tahmasbi , Faghihi Shahab
Published: January 2019

The aim of this study is to emphasize a neglected aspect of the surface properties of metallic implants. The authors have investigated the effects of the different forming processes on the atomic arrangement and subsequent biological activity of the surface of titanium (Ti)-based materials. First, the authors have shown how the fabrication method can influence titanium implants’ surface grain orientations. Implants were exposed to simulated body fluid (SBF) and cell culture experiments to analyze their biological activity afterward. Pole figure and orientation distribution function measurements indicate that the main crystallographic orientation is (10-10) in the extruded sample, while (0002) is determined as the predominant crystallographic plane in the rolled sample. Grazing-angle X-ray diffraction and scanning electron microscopy analyses of the substrates after immersion in SBF show that the number and sizes, as well as morphology, of calcium phosphate crystals formed on the surface of the samples are clearly dissimilar. The biological assessments of the implants with human bone marrow mesenchymal stem cells have shown that the Ti-(10-10) orientation is the favored orientation for hard tissue regeneration. This research shows how the crystallographic orientation of metallic materials can be used to improve the biological activity of biomaterials in contact with bone tissue.
An Inductive Study on the Authenticity of Voluntourism
Authors:   The Tourism Sciences Society Of Korea, Kim Ye-Ji , Kim Hong-bumm
Published: January 2019

The present study was conducted to define the meaning of voluntourism and to develop its value in tourists’ experience by demonstrating the authenticity of voluntourism as a form of alternative tourism. For the purpose of projecting the theoretical construct into more manageable research scales, authenticity of tourism was deducted by the three steps of collecting and categorizing, rearranging the collected 60 data samples in an on-line community for voluntourism, and drawing conclusions. In order to analyze the collected data systematically, 25 voluntourism cases were selected according to spatial criteria of countries, content criteria of activity, and personal criteria of motivation. Through the components of voluntourism experiences that appeared in the 25 selected cases, authenticity of voluntourism was derived by inductive inference. Finally, three major experiences of voluntourism were delineated as representative authenticity of tourism, which were mentioned most frequently in the total data set. As an inductive conclusion of this study, these experiences were denominated as “pursuing experience for the exotic environment,” “pursuing experience for self-growth,” and “pursuing experience for cultural exchange.” The characteristics and the ways of interpretation of the authenticity of voluntourism derived in this study are expected to suggest valuable implications for useful baseline data in understanding tourists’ needs for voluntourism as an important form of alternative tourism.
Developing Indicators to Forecast the Optimal Number of Employees for Hotel MICE
Authors:   The Tourism Sciences Society Of Korea, Kim Yung-Moon , Kim Chulwon
Published: January 2019

This study developed indicators to forecast the optimal number of employees for hotel MICE and to investigate empirically the reliability and validity of those indicators. The dominant approach to manpower planning has long been based on heuristic experience in the hotel and MICE fields, and there is little research in hotel and MICE studies. A focus group interview and two rounds of Delphi technique were conducted to achieve the study goal. Moreover, 289 samples were collected to test the validity and the reliability of the finalized indicators. The study developed 35 indicators with seven factors. This study contributes to the academic and the practical hospitality sectors by helping to identify indicators that would allow a more accurate forecast of the optimal number of employees for hotel MICE.
The Effect of Tourists’ Satisfaction and Behavioral Intention on the Experience Economy Constructions of Mobile Applications Using Augmented Reality Technology
Authors:   The Tourism Sciences Society Of Korea, Park Jin-Hee , Yoon Ji-Hwan
Published: January 2019

With the continuing advancements in augmented reality (AR) technology, there is a growing interest in developing AR mobile applications for the tourism industry. However, there is a lack of research on AR contents related to tourism. Most studies have focused on the technological applications of AR and have not truly considered what factors affect how users actually use them. This study analyzed “Visited Changgyeong Palace in My Hand” and adapted experience economy constructions in order to evaluate AR apps to prove that the constructions have an effect on tourists' satisfaction and behavioral intention. An individual survey was conducted to tourists who had experienced that AR app. The results of this study found that all experience economy constructions showed a positive influence on the satisfaction of tourists. In addition, it indicated that satisfaction had a direct significant influence on tourists' behavioral intention. Finally, these results demonstrated convincingly that experience economy constructions could be applied to AR apps in the tourism industry. These results could help developers find a proper development direction for AR apps.
Bioinformatic pipeline for studying transcriptome and regulome dynamics during neural differentiation v5
Authors: Shang Zhouchun , Chen Dongsheng , Wang Quanlei , Wang Shengpeng
Published: January 2019

Here we present a bioinformatic pipeline for dissecting transcriptional regulation of neural differentiation process. Single cell RNA-seq and bulk ATAC-seq with two biological replicates was applied to the indicated cell stages including human induced pluripotent stem cells (hiPSCs), embryoid body (EB), early rosettes (Ros-E), late rosettes (Ros-L), neural progenitor cells (NPCs), and the original somatic fibroblasts (Fib) for a deeper understanding of the regulatory mechanisms driving the differentiation of the neural lineage. This pipeline could be applied to study transcriptome and regulome dynamics of other lineages.
THE INFLUENCE OF HISTORICAL MEMORY ON MODERN UKRAINIANS’ POSTCOLONIAL SYNDROME OVER COME
Authors: Dotsenko Victor
Published: January 2019

The attempts to determine main fundamental historical myths, which were used by soviet and modern Russian ideologists for soviet person historical conscience formation and their overcome in modern Ukraine are represented in the article on the basis of scientific works, analysis of existent historians, political social analysts. The concept of «nation’s friendship» dominated in historiography and public discussions in USSR during the decades. This concept successfully hided soviet type of imperialism and colonialism. It was the inheritance of new Ukrainian state. The struggle for Ukrainian nation’s conscience between Ukraine and imperial Russia continued during the whole modern history of Ukrainian state. Russia tries to privatize the historical memory about Slavonic state origin and to use it for new imperial ideological project creation. Ukrainian scientistsand culture figures firmly resist to Russian ideological offensive at the same time getting tiny support from politicians. The winner in the war for national Ukrainian identity saving and Ukrainian political nation creation is going to be a person who will reveal the real Ukrainian history without ideological myths and post-imperial stereotypes.
Declaraciones y garantías en fusiones y adquisiciones empresariales: una aproximación desde el interés contractual y la teoría de la causa
Authors: Escandón Lozano Caludia Lorena
Published: January 2019

In contracts for the sale of shares and acquisitions of companies, it is very common to find the so-called "Declarations and Guarantees" clause. In it, the parties usually make a series of statements that inform about the quality and origin of the thing sold -which is precisely the Company-; as well as statements that provide important and necessary information to contract (financial statements, the status of the actions, the pending litigation, the handling of labor issues, hidden liabilities, licenses, industrial property, contracts, etc.). Once these statements are made, responsibilities are assumed for the veracity, accuracy or accuracy of the information provided, to the point of preaching a breach of contract otherwise. In this article I intend to make an analysis of the scope and meaning of this legal concept, in the particular Colombian context, focusing on the theories of the "legal cause" and on solving the question of what is the way in which its breach is corrected when you are They are false or inaccurate.
STRATIGRAPHIC ASPECTS AND FACIES DESCRIPTION OF MIRANDIBA BASIN, NORTHEAST, BRASIL
Authors: Pereira Laís Cristina Leite , De Araujo Luis Henrique Aguiar , Da Silva Gisely Maria , De Lima Filho Mário Ferreira
Published: January 2019

A Bacia Mirandiba, localizada na porção central do estado de Pernambuco, representa uma das bacias interiores do Nordeste. Considerando a falta de estudos em geologia nesta área, esta pesquisa tem como objetivo documentar e descrever os principais aspectos sedimentológicos e faciológicos observados na Bacia de Mirandiba. A metodologia envolveu além da observação de imagens do Google Earth, a análise do Modelo Digital de Elevação (DEM), derivado do SRTM (Shuttle Radar Topography Mission), ambas com intuito de proporcionar uma melhor visualização da área e seleção dos melhores afloramentos. Quatro formações sedimentares foram identificadas neste estudo. ALaís Cristina Leite Pereira et al.Formação Tacaratu (Siluro-Devoniano) representa os sedimentos mais abundantes e antigos da bacia e é composta por fácies essencialmente arenosas. Como características principais estão a presença de bandas de deformação principalmente na borda da bacia, além da comum presença de níveis conglomeráticos. A Formação Inajá, localizada estratigraficamente acima da Formação Tacaratu, é marcada por fácies arenosas (compostas por arenitos vermelhos contendo, por vezes, nódulos limoníticos) e por uma fácies siltítica. A Formação Aliança é composta por duas facies: (i) folhelhos vermelhos a marrons, representando a fácies mais abundante e (ii) arenitos calcíferos, geralmente intercalados entre camadas da fácies anterior. A Formação Sergi, a qual apresenta a menor extensão, é dominantemente marcada por presença de fácies arenosa, no entanto, também são observadas fácies conglomerática e siltosa. Quatro associação de fácies (S1, S2, S3 and F1) foram descritas para caracterizar os dois principais sistemas deposicionais da Bacia Mirandiba. A associação de fácies S1, S2 e S3 caracterizam um sistema fluvial entrelaçado associado as formações Tacaratu, Inajá e Sergi, enquanto a associação F1 descreve um sistema deposicional lacustre caracterizado na Formação Aliança.
A study on prevalence of chronic kidney disease and its risk factors among adults in selected slums of Chennai
Authors: Kokila K. , Chellavel Ganapathi K.
Published: January 2019

Background: Chronic kidney disease (CKD) is a silent epidemic. The true prevalence of CKD with in a population are very difficult to estimate, since early to moderate CKD were usually asymptomatic. ESRD in the consequence of CKD is one of the most expensive diseases to treat.Only way is to prevent it and Hence this was conducted to estimate the prevalence of CKD and its associated risk factors among adults in selected slums of Chennai.Methods: This is a cross sectional study done from May 2013 to June 2014 in selected slums of Chennai. The study population includes adult males and females. Multi stage sampling method used. Sample size covered was 400. A semi structured questionnaire used as tool. Based on the serum creatinine eGFR calculated using modified MDRD study equation and CKD prevalence was identified. The data was entered in MS excel and analyzed using SPSS version 21.Results: Total of 400 participants involved. Females were predominant in the study. Among them, 67 (16.8%) were diagnosed as CKD patients and Stage 1, 4.0% had stage 2, 3.6% had stage 3, 1.3% had stage 4 and 0.5% had stage 5 at the time of diagnosis.Conclusions: This study revealed prevalence of CKD among slum population was 16.8%. This study showed that old age, uncontrolled hypertension, uneducated, Diabetes with poor control, overuse of analgesics, H/o smoking, obesity, alcoholism, passive smoking, family H/o CKD and proteinuria were significant risk factor for CKD among study subjects. Slum population with risk factors should be regularly screened for CKD.
The prevalence and associated factors of viral hepatitis and cryptogenic related hepatocellular carcinoma at King Abdulaziz Medical city-Riyadh
Authors: Alhaqbani Abdulaziz H. , Almusalam Abdulaziz , Alnadhari Abdulaziz , Alsalem Abdulmalik , Alrasheed Meshal , Alalwan Abduljaleel , Aldamkh Bander
Published: January 2019

Background: Worldwide, viral hepatitis is the major risk factor for HCC with hepatitis B (HBV) being more than hepatitis C (HCV). Saudi Arabia is one of the endemic areas of viral hepatitis. Cryptogenic HCC is thought to arias from unknown causes of liver cancers. Thus, the purpose of this study was to find the prevalence of viral and cryptogenic HCC in King Abdulaziz Medical City-Riyadh (KAMC-R).Methods: A retrospective chart review was performed for all HCC patients diagnosed between 2010 to 2017 at KAMC-R. Information regarding age, gender, comorbidity, alcohol consumption, serology tests, liver enzymes, body mass index, model for end-stage liver disease score, alpha-fetoprotein and Child-Turcotte-Pugh score were included. The Chi-square test was used to determine the differences between categorical data. A p<0.05 was considered statistically significant.Results: Total of 294 patients with HCC charts were reviewed. HCV and HBV were found in 42.85% and 20.74% of the patients, respectively. Co-infection with HBV and HCV were reported in 1.7% whereas cryptogenic HCC was found in 32.65% of the patients. High BMI and DLP were noticeably higher in cryptogenic group (p=0.045 and p=0.022 respectively). Multiple lesions were noticed more in HCV group whereas single lesion was more in the cryptogenic group (p=0.0343). Also, large lesions (>5 cm) were remarkably found more in cryptogenic HCC whereas small lesions were more in HCV group (p=0.006).Conclusions: Hepatitis C was the major risk factor associated with HCC, followed by Cryptogenic HCC. High BMI and DLP were common features of cryptogenic HCC.
Scrutinizing the patients with breast lump on fine needle aspiration cytology
Authors: Samad Afra , Fayyaz Nudrat , Ali Kanwar Sajid , Ashraf Aqsa , Mahmood Namra , Kashif Muhammad
Published: January 2019

Background: One of the most common medical problems, women face today, is a lump in the breast. These lumps may range from simple inflammatory to malignant. In case of carcinoma, early and accurate diagnosis can save the patient from metastases thus reducing mortality and morbidity. The aim of the present study is to see the spectrum of lesion in breast lump specimens in Ibn e Sina Hospital, Multan Medical and Dental College, Multan over a period of ten years.Methods: This retrospective study was carried out in the Department of Pathology, Multan Medical and Dental College Multan, Pakistan. Data were gathered from the archives of Pathology laboratory, comprising of years 2007 t0 2017, after approval from Institutional Ethical Review Committee. All the patients presented with complaint of any kind of swelling of breast were included in this study. All the demographic and clinical details of the patients were collected on proforma. Fine needle aspiration technique was used to take sample from the suspected lesional area. Descriptive statistics was used to analyze the data.Results: A total of 2039 patients were presented with complaint of lump/swelling in their breast unilaterally or bilaterally. There were 628 (30.8%) benign lesions, 872 (42.8) malignant lesions, 229 cases with atypical cells. Mastitis/inflammatory lesions were seen in 167 (8.2%) cases and tuberculous granulomas were observed in 83 (4.07%) cases. Twenty cases were of miscellaneous types including lipoma, phylloda, simple cysts etc.Conclusions: Findings of present study show that majority of breast lumps were malignant, benign, inflammatory and tuberculous respectively.
Supracondylar fracture of femur: our experience of treatment with locking compression plate from rural Maharashtra
Authors: Paknikar Kiran P. , Malve Shekhar , Kulkarni G. S. , Kulkarni M. G. , Kulkarni S. G. , Takalkar Anant A.
Published: January 2019

Background: Surgical treatment of supracondylar or intercondylar distal femoral fractures (AO/OTA types 33-A to 33-C) remains a significant surgical challenge with significant complication rates. Supracondylar and intercondylar fractures of femur are very often difficult to treat and they are notorious for many complications. We have studied use of LCP (locking compression plate) in the treatment of metaphyseal fractures. These implants improve fracture healing, especially in osteoporotic bone due to better holding capacity. Objective wass to assess the efficacy of LCP in maintenance of post-operative distal femoral alignment and in preventing post-operative varus collapse in supracondylar fracture of femur.

Methods: Prospective Longitudinal observational study Conducted at Post Graduate Institute of Swasthiyog Pratishthan, Miraj, Maharashtra involving 50 patients with supracondylar fracture. The fractures were classified as supracondylar femur fracture (AO/OTA type 33) (A- C). Fractures that were supracondylar with significant proximal fracture extension were classified as an AO/OTA type 33 fracture unless there was a separate diaphyseal fracture. Data was analysed by using SPSS 16.0 version and expressed as percentages.

Results: Majority of patients were from 30-39 years age group i.e. 32%. Majority of patients were males i.e. 46 (92%). 7 (14%) patients had healing time <4 months. 24 (48%) patients had healing time between 4-6 months. 19 (38%) patients had healing time more than 6 months. To assess the overall results, we used Knee society score. In 38% of patients, we found excellent results. Good and fair results were seen in 32% and 26% of patients.

Conclusion: Locking compression plate is an ideal implant for fixation of supracondylar fracture of femur 33 (A-C) especially in C3 type where articular comminution is present.
Ulnar dimelia: a rare case
Authors: Mathun Ram C. , Chidambaranathan G.
Published: January 2019

Mirror hand deformity or ulnar dimelia is a congenital anomaly and several papers presented in various journals. We received a patient a child of four years old with deformity of right upper limb. The child had fixed elbow of 10 and many fingers. Fingers were symmetrical to the midline axis and X-ray showed double ulna facing each other and Inner/medial ulna is longer than the lateral one. This is a rare entity and not reported till now in any literatures.
Simultaneous Angiography for the Anterior Segment and Posterior Fundus of Eyes with Anterior Segment Neovascularization using Heidelberg Retina Angiograph 2
Authors: Sakino Yuji , Noda Yoshihiro , Itotani Maho , Nakamuro Takako , Kiyosaki Kunihiro , Yokoyama Katsuhiko , Kubota Toshiaki
Published: January 2019

Objective: To present a method of indocyanine green angiography (IA) and fluorescein sodium angiography (FA) for simultaneously evaluating anterior segment neovascularization and fundus abnormality.Participants: We examined 19 eyes of 19 patients suspected of having neovascularization in the anterior segment of the eye. Seventeen eyes of 17 patients suffered from proliferative diabetic retinopathy, and two eyes of 2 patients had central retinal vein occlusion.Methods: Using Heidelberg Retina Angiograph 2 (HRA2), we performed angiography of the anterior and posterior segment of the eye.Results: Of the 19 cases, anterior segment neovascularization was clearly observed with slit-lamp examination and gonioscopy in 12 eyes (63.1%). However, anterior segment neovascularization was detected by HRA2 angiography in 18 eyes (94.7%). Posterior segment angiography revealed non-perfusion area in 16 eyes (84.2%) and retinal neovascularization in 10 eyes (52.6%). In one case, the posterior segment findings were not obtained due to vitreous hemorrhaging.Conclusion: Simultaneous anterior and posterior segment HRA2 angiography using indocyanine green andfluorescein sodium is a useful technique for detecting neovascularization in the anterior segment of the eye as well as non-perfusion areas and neovascularization of the retina.
Control of Ni/Ce1-xMxOy Catalyst Properties Via the Selection of Dopant M = Gd, La, Mg. Part 2. Catalytic Activity
Authors: Kerzhentsev M.A. , Matus E.V. , Ismagilov I.Z. , Sukhova O.B. , Bharali P. , Ismagilov Z.R.
Published: January 2019

To elucidate the role of support composition in autothermal reforming of ethanol (ATR of C2H5OH), a series of Ni catalysts (Ni content 2–15 wt.%) supported on different ceria-based oxides (Ce1-xGdxOy, Ce1-xLaxOy and Ce1-xMgxOy; x = 0.1–0.9) were prepared. The synthetized materials were tested in ATR of ethanol at 200–700 °C. It was established that supports themselves show catalytic activity in ATR of C2H5OH and provide 10–15% yield of H2 at 700 °C. Upon the increase of Ni content from 2 to 15 wt.% the temperature of 100% ethanol conversion decreases from 700 tо 300 °С, hydrogen yield increases from 25 to 60%, the inhibition of С2-С3 by-products formation, as well as the promotion of decomposition of acetaldehyde occur. The enhancement of catalyst performance in ATR of C2H5OH has been observed in the next series of supports: Ce1-xMgxOy < Ce1-xGdxOy < Ce1-xLaxOy and with a decrease of x to an optimal value that correlates with the improvement of Ni active component reducibility. At 600 °C on 10Ni/Ce0.8La0.2O1.9 catalyst the H2 yield of 50% was achieved at C2H5OH conversion of 100%. Stable and high performance of developed catalysts in ATR of C2H5OH indicates the promise of their use in the production of hydrogen.
Fabrication of Cu-W Nanocomposites by Integration of Self-Propagating High-Temperature Synthesis and Hot Explosive Consolidation Technologies
Authors: Aydinyan S.V. , Kirakosyan H.V. , Zakaryan M.K. , Abovyan L.S. , Kharatyan S.L. , Peikrishvili A. , Mamniashvili G. , Godibadze B. , Chagelishvili E.Sh. , Lesuer D.R. , Gutierrez M.
Published: January 2019

Manufacturing W-Cu composite nanopowders was performed via joint reduction of CuO and WO3 oxides with various ratios (W:Cu = 2:1, 1:1, 1:3, 1:13.5) using combined Mg–C reducer. Combustion synthesis was used to synthesize homogeneous composite powders of W-Cu and hot explosive consolidation (HEC) technique was utilized to fabricate dense compacts from ultrafine structured W-Cu powders. Compact samples obtained from nanometer sized SHS powders demonstrated weak relation between the susceptibility and the applied magnetic field in comparison with the W and Cu containing micrometer grain size of metals. The density, microstructural uniformity and mechanical properties of SHS&HEC prepared samples were also evaluated. Internal friction (Q-1) and Young modulus (E) of fabricated composites studied for all samples indicated that the temperature 1000 °С is optimal for full annealing of microscopic defects of structure and internal stresses. Improved characteristics for Young modulus and internal friction were obtained for the W:Cu = 1:13.5 composite. According to microhardness measurement results, W-Cu nanopowders obtained by SHS method and compacted by HEC technology were characterized by enhanced (up to 85%) microhardness.
Analysis of Тhermal-Нydraulic Сharacteristics of Сomposite Рipes Сompared to Мetallic and Рolymeric Мaterials
Authors: Stepanova T.A. , Strogonov K.V. , Fedyukhin A.V. , Khoreva P.V. , Bernadiner I.M.
Published: January 2019

A brief analysis of the thermal networks in the Russian Federation with evidence of upgrading necessity of the existing pipeline system is presented. A comparison of the various existing and promising materials of pipelines and thermal insulation from the point of view of their thermal-hydraulic characteristics are presented. It’s estimated an economic effect for the reduction of thermal and hydraulic losses in the comparison of composite and metal piping length of 1000 meters. It is shown that the optimum thickness of thermal insulation composite piping can be taken smaller than for the metal tube 4-5 mm.
Mobile Installation of Water Treatment in the Aftermath of Emergency Situations
Authors: Alexandrov R.A. , Feklistov D.Yu. , Laguntsov N.I. , Kurchatov I.M.
Published: January 2019

A new technological scheme of water treatment is proposed, combining reagent methods with hydrodynamic activation of coagulation, flocculation and sorption processes, with baromembrane methods of purification. A method of organizing the process of filtering water after treatment with reagents using a tangential filter made using self-propagating high-temperature synthesis technology is proposed. Jet agitators – ejectors were developed and investigated, the efficiency of using ejectors as devices for dosing and mixing of reagents with treated water was shown. An experimental model of the installation was created and it was successfully tested on model as well as real polluted waters. Purified water obtained on an experimental sample of the installation fully complies with the hygienic requirements and standards established for drinking water.
PC-lattices: A Class of Bounded BCK-algebras
Authors: Shoar Sadegh Khosravi , Borzooei Rajab Ali , Moradian R. , Radfar Atefe
Published: January 2019

In this paper, we define the notion of PC-lattice, as a generalization of finite positive implicative BCK-algebras with condition (S) and bounded commutative BCK-algebras. We investiate some results for Pc-lattices being a new class of BCK-lattices. Specially, we prove that any Boolean lattice is a PC-lattice and we show that if X is a PC-lattice with condition S, then X is an involutory BCK-algebra if and only if X is a commutative BCK-algebra. Finally, we prove that any PC-lattice with condition (S) is a distributive BCK-algebra.
Variable Sharing in Substructural Logics: an Algebraic Characterization
Authors: Badia Guillermo
Published: January 2019

We characterize the non-trivial substructural logics having the variable sharing property as well as its strong version. To this end, we find the algebraic counterparts over varieties of these logical properties.
Pseudo-BCH Semilattices
Authors: Walendziak Andrzej
Published: January 2019

In this paper we study pseudo-BCH algebras which are semilattices or lattices with respect to the natural relations ≤; we call them pseudo-BCH join-semilattices, pseudo-BCH meet-semilattices and pseudo-BCH lattices, respectively. We prove that the class of all pseudo-BCH join-semilattices is a variety and show that it is weakly regular, arithmetical at 1, and congruence distributive. In addition, we obtain the systems of identities defininig pseudo-BCH meet-semilattices and pseudo-BCH lattices.
Gesty i rytuały niewerbalne oraz ich znaczenie w obecnej polityce polskiej
Authors: Antas Jolanta , Kozień Michał
Published: January 2019

W artykule poddaliśmy analizie niewerbalne zachowania i niewerbalne rytuały przedstawicieli Prawa i Sprawiedliwości, partii aktualnie rządzącej. Na podstawie naszych obserwacji i analizowanych materiałów filmowych zauważyliśmy trzy nowe podstawowe tendencje w niewerbalnych rytuałach wystąpień publicznych na polskiej scenie politycznej. Po pierwsze, wystąpienia polityków obecnej władzy charakteryzuje ubogość gestyczna w publicznej narracji, która ogranicza się na ogół do zachowań adaptacyjnych, mających na celu zwiększenie komfortu mówcy kosztem uplastycznienia jego werbalnych wywodów. Po drugie, zauważyliśmy, że większość tak zwanych emblematów obscenicznych, czyli gestów wyrażania pogardy, braku szacunku czy lekceważenia, pojawia się w przestrzeni, w której nie powinny się zdarzać – w parlamencie i sytuacjach publicznych, z czego wnioskujemy, że partia rządząca zrezygnowała z zasad politycznej poprawności. Po trzecie, zaobserwowaliśmy na tej scenie jawne łamanie i zaburzanie zakorzenionych w kulturze obyczajów i rytuałów, a także mieszanie dwóch sfer rytuałów: sacrum i profanum.
Chwyty negocjacyjne – przegląd zagadnień
Authors: Nęcki Zbigniew
Published: January 2019

Artykuł zawiera przegląd klasycznych i współczesnych sposobów manipulacji w negocjacjach, tak ważnych, jak cała szkoła neurolingwistycznego programowania czy subtelniejsze podejście dysonansu poznawczego. Omawia się również koncepcje z pogranicza manipulacji, czyli analizę transakcyjną Erica Berne’a i konsek- wentne chwyty, zwane erystyką Schopenhauera. Bezpośrednio w negocjacjach stosowane są chwyty ujęte w pięciu strategiach kooperacyjnych i pięciu strategiach dystrybucyjnych. Pragmatyka negocjacji sugeruje, że orientacja współpracy jest bardziej preferowana niż strategia zwycięstwa jednostronnego.
Sposoby wspierania tez w programach informacyjnych
Authors: Czechowski Wiesław
Published: January 2019

W artykule opisane są sposoby wspierania tez w telewizyjnych programach informacyjnych. Jako materiał badawczy służą wydania trzech najpopularniejszych w Polsce programów: Faktów, Wiadomości oraz Teleexpressu. Analizie poddano informacje wyemitowane w dniach 1–3 marca 2017 r. W wyniku analizy udało się ustalić źródła pochodzenia tez – są cytatami, parafrazami wypowiedzi osób publicznych lub konkluzjami dziennikarskimi, które stanowią efekt interpretacji zjawisk społeczno-politycznych. Tezy, o których mowa, są werbalizowane przez dziennikarzy (prowadzących program lub terenowych) lub zawarte w narracjach towarzyszących prezentowanym materiałom filmowym. Dodatkowo pojawiają się także w graficznie animowanych napisach banerowych. Wsparcie tez najczęściej ma postać werbalną – media posługują się przede wszystkim dwiema technikami: ab auctoritate (wypowiedzi eksperta, polityka) oraz ab exemplo. Drugą grupę stanowią graficzne sposoby wspierania tez, gdzie przesłanki, dowody i przykłady najczęściej zaczerpnięte są ze źródeł internetowych: dominują tu owoce aktywności osób publicznych w mediach społecznościowych. Ponadto prezentowane są skany różnych dokumentów urzędowych, listów otwartych, rzadziej pojawiają się wizualizacje danych w postaci tabel, wykresów i diagramów. Wykryto także tezy bez wsparcia – jego rolę pełni wiarygodność medium. Ciekawy zabiegiem jest zachęcanie do aktywności inferencyjnej widzów programu – prezentowane są wyłącznie przesłanki, stworzenie konkluzji to już zadanie odbiorcy.
Techniki komponowania obrazowania w tekstach kabaretonu
Authors: Czechowski Wiesław , Ozga Krzysztof
Published: January 2019

Artykuł stanowi analizę technik komponowania obrazowania w tekstach kabaretonu. Autorzy wychodzą z założenia, że dyskurs kabaretowy to układ interakcyjny, w którym standardowym celem zachowania komunikacyjnego twórców kabaretowych jest rozśmieszanie audytorium, a standardowy cel podjęcia roli odbiorcy tekstu kabaretowego stanowi zabawa. Twórcy kabaretowi do budowania obrazowania korzystają z innych dyskursów, zatem autorzy próbują odpowiedzieć na następujące pytanie badawcze: Jakie sposoby operowania dyskursem(ami) doprowadzają twórców kabaretowych do osiągnięcia celu interakcyjnego? Materiałem empirycznym jest skecz popularnej polskiej grupy kabaretowej Nowaki pt. Nauczyciele. Metodologia badania opiera się przede wszystkim na założeniach gramatyki komunikacyjnej. Analiza pokazuje, że dyskurs kabaretowy operuje technikami obrazowania, które kreują niestandardowe punkty dostępu do skryptów, scenariuszy czy stereotypów, bazujące na ich pogwałceniu lub negatywnej hiperbolizacji, wykorzystujące repertuar środków językowych, takich jak metafora, intertekstualność, polisemia, operacje na poziomie fonologicznym czy odniesienie do hyperdyskursu.
Bright and Singular Soliton Solutions of Tzitzéica Type Equations Appear in Nonlinear Optics
Authors: Zafar Asim , Korkmaz Alper , Qureshi Muhammad Imran , Fahad Asfand
Published: January 2019

We investigate the exact travelling wave solutions of the Tzitzéica-Dodd–Bullough–Mikhailov (TDBM) and Tzitzéica-type (TT) equations, appear in nonlinear optics, using simple ansatz approach. We use the Painlevé and traveling wave transformations to convert the mentioned nonlinear equations into nonlinear ordinary differential equations. Then, the simple ansatz approach has been employed to procure wave solutions, in terms of bright, singular soliton and trigonometric functions, for the Tzitzéica-Dodd–Bullough–Mikhailov (TDBM) and Tzitzéica-type (TT) equations. The study shows that the simple ansatz approach is straightforward and easy to implement for solving nonlinear problems.
The Cancer Aneuploidy Paradox: In the Light of Evolution
Authors: Salmina Kristine , Huna Anda , Kalejs Martins , Pjanova Dace , Scherthan Harry , Cragg Mark S. , Erenpreisa Jekaterina
Published: January 2019

Aneuploidy should compromise cellular proliferation but paradoxically favours tumour progression and poor prognosis. Here, we consider this paradox in terms of our most recent observations of chemo/radio-resistant cells undergoing reversible polyploidy. The latter perform segregation of two parental groups of end-to-end linked dyads by pseudo-mitosis creating tetraploid cells through a dysfunctional spindle. This is followed by autokaryogamy and homologous pairing preceding a bi-looped endo-prophase. The associated RAD51 and DMC1/γ-H2AX double-strand break repair foci are tandemly situated on the AURKB/REC8/kinetochore doublets along replicated chromosome loops, indicative of recombination events. MOS-associated REC8-positive peri-nucleolar centromere cluster organises a monopolar spindle. The process is completed by reduction divisions (bi-polar or with radial cytotomy including pedogamic exchanges) and release of secondary cells and/or formation of an embryoid.  Together this process preserves genomic integrity and chromosome pairing, while tolerating aneuploidy by by-passing the mitotic spindle and meiotic SC checkpoints. Concurrently, it reduces the chromosome number and facilitates recombination that decreases the mutation load of aneuploidy and lethality in the chemo-resistant tumour cells. This cancer life-cycle has parallels both within the cycling polyploidy of the asexual life cycles of ancient unicellular protists and cleavage embryos of early multicellulars, supporting the atavistic theory of cancer.
A Comparative Study of YSZ Suspensions and Coatings
Authors: Tarasi Fariba , Alebrahim Elnaz , Dolatabadi Ali , Moreau Christian
Published: January 2019

The demand for suspensions used in thermal spray processes is expanding from research labs using the lab-prepared suspensions toward actual coating production in different industrial sectors. Industrial applications dictate reduced production time and effort which may in turn justify the development of the market for ready-to-use commercial suspensions. To this end, some of the powder suppliers have already taken steps forward by introducing to the market suspensions of some of the most used materials such as yttria-stabilized zirconia (YSZ), alumina and titania. There is, however, a need to compare the suspension characteristics over time and the resultant coatings when using these suspensions as compared with the freshly prepared home-made suspensions. In this work, such comparison is done using YSZ suspensions of the sub-micron to a few micron powders. In addition, some changes in the suspensions' formula were performed as a tool to vary the coatings’ microstructures in a more predictable way, without variation of spray parameters. The coatings were generated using both radial and axial injection of the suspensions into Oerlikon-Metco 3MB and Mettech Axial III plasma spray torches, respectively. A clear effect of suspension viscosity on the coating microstructure was observed using the 3MB torch with radial injection of suspension (i.e. cross flow atomization). The viscosity role, however, was not dominant when using the Axial III torch with axial feed injection system (i.e. coaxial flow atomization).
Electroconductive Additives for High-Rate Capability of High-Areal-Capacity Lithium–Sulfur Batteries Using Metal-Foam Current Collector
Authors: Nara Hiroki , Yokoshima Tokihiko , Mikuriya Hitoshi , Tsuda Shingo , Osaka Tetsuya
Published: January 2019

Various types of electroconductive additives were evaluated for high C-rate capability in an attempt to extend practical application of high-areal-capacity lithium–sulfur batteries that employ an aluminum-foam current collector. Carbon nanofibers (CNFs) were found to be the most effective additive, with the ability to attain a high-sulfur-loading of 40 mg cm−2. A CNF-containing cell exhibited gravimetric capacities of 1094 and 758 mAh gsulfur−1 (46.8 and 32.4 mAh cm−2) at 0.05 and 0.1 C-rate, respectively, in an ether-based electrolyte. Because a CNF-containing slurry exhibits low viscosity even at a high solid ratio, it could be filled into the aluminum foam. Additionally, a lithium–sulfur battery with high-sulfur-loading had an energy density of ~120 Wh kg−1, a value that was calculated from the weight of the components of the cathode, anode, current collectors, electrolyte, and separator. Assuming that the amount of electrolyte decreases and that the energy density of cells accumulate, a theoretical energy density of 522 Wh kg−1 was estimated. Moreover, it was found that even if a high-areal-capacity was achieved, the discharge capacity converged at a high C-rate, unless there was an improvement in ion diffusion in the bulk electrolyte. This is considered a limitation of sulfur cathodes with high-sulfur-loading.
IRES Trans-Acting Factors, Key Actors of the Stress Response
Authors: Godet Anne-Claire , David Florian , Hantelys Fransky , Tatin Florence , Lacazette Eric , Garmy-Susini Barbara , Prats Anne-Catherine
Published: January 2019

The cellular stress response corresponds to the molecular changes that cell undergoes in response to various environmental stimuli. It induces drastic changes in the regulation of gene expression, at transcriptional and post-transcriptional levels. Actually, translation is strongly affected with a blockade of the classical cap-dependent mechanism, whereas alternative mechanisms are activated to support translation of specific mRNAs. One of the major mechanisms involved in stress-activated translation is the internal ribosome entry site (IRES)-driven initiation. IRESs, first discovered in viral mRNAs, are present in cellular mRNAs coding for master regulators of cell responses, whose expression must be tightly controlled. IRESs allow translation of these mRNAs in response to different stresses, including DNA damage, amino-acid starvation, hypoxia or endoplasmic reticulum stress, as well as to physiological stimuli such as cell differentiation or synapse network formation. Importantly, cellular mRNA IRESs are regulated by IRES trans-acting factor (ITAFs), exerting their action by at least nine different mechanisms. This review presents an update of the reported ITAFs regulating cellular mRNA translation and of the different mechanisms allowing them to control translation initiation in specific conditions. The impact of ITAFs on coordinated expression of mRNA families and consequences in cell physiology and diseases are also highlighted.
Characterization of Collagens Fibers (I, III, IV) and Elastin in the Extracellular Matrix of Normal and Neoplastic Canine Prostate
Authors: Calderón Luis Gabriel Rivera , Kobayashi Priscila Emiko , Vasconcelos Rosemeri Oliveira , Fonseca-Alves Carlos Eduardo , Laufer-Amorim Renee
Published: January 2019

Collagen (Coll) is the most common protein in the extracellular matrix, responsible for providing tissue structure and support. In some types of cancer, including prostate cancer (PC) abundant collagen was identified and related to tumor progression and metastasis. This study aimed to investigate Coll-I, III, IV and elastin in normal canine prostatic tissue and PC, using the Picrosirius red (PSR) and Immunohistochemical (IHC) analysis. Eight normal prostates and 10 PC from formalin-fixed, paraffin-embedded samples were used. Collagen fibers area was analyzed with ImageJ software. The distribution of Coll-I and Col-III was approximately 80% around prostatic ducts and acini, 15% among smooth muscle and 5% around in blood vessels, in both normal prostate and PC. Immunostaining for type IV collagen was observed in the basal membrane of prostate acini, smooth muscle, blood vessels, and never fibers of normal and PC samples. Elastic fibers were found in the septa dividing the lobules and around the prostatic acini of normal samples. A high amount of elastic fibers was observed around the ducts and the urethra in normal and canine PC. The distribution and area percentage of staining for collagen are similar in normal and neoplastic canine prostate when analyzed with PSR and IHC.
Patellar Height Assessment Methods
Authors: Igoumenou Vasilios G. , Dimopoulos Leonidas , Mavrogenis Andreas F.
Published: January 2019

* Direct and indirect radiographic methods have been proposed for patellar height assessment. Direct methods relate the position of the patella to the femur, and indirect methods relate the position of the patella to the tibia.

* Various knee flexion angles have been used for practicality or because obtaining a true lateral knee radiograph is difficult. Knee flexion angles and quadriceps contraction modify patellar height measurements because of proximal patellar displacement and influence patellar height ratios.

* Over time, progression from a simple radiographic measurement to modern biomechanical and imaging technologies has added complexity to the techniques devised to measure patellar height. Currently, the definition of patellar height and its causal relationship to the conditions commonly associated with anterior knee pain remain controversial.
Presentación: Orientación profesional para el aprendizaje de lenguas en el mundo de la información y la comunicación
Authors: Gómez Parra Mª Elena , Huertas Abril Cristina A.
Published: January 2019

La enseñanza y el aprendizaje de segundas lenguas es, hoy día, uno de los ejes educativos más importantes y con mayor relevancia en los organismos internacionales de referencia, erigiéndose como una prioridad para, entre otros, la Comisión Europea: «Linguistic and cultural diversity is one of the European Union’s major assets» en palabras de Vassiliou, Comisionado para la Educación, Cultura, Multilingüismo y Juventud (http://europa.eu/rapid/press-release_IP-12-990_en.htm). No cabe duda del papel predominante del inglés y del español en este paradigma, pues se trata de dos lenguas mayoritarias de intercambio para la ciencia, la divulgación, el trasvase cultural y, desde luego, constituyen una magnífica base sobre la que construir la convivencia pacífica de los pueblos.
J. OFFENBACH VE “GÜZEL HELEN” OPERETİ
Authors: GÜLLÜ Eren
Published: January 2019

Operet; konusu, orkestrasyonu, librettosu ve
müziği açısından daha hafif, kısa ve sade sahne eserine verilen addır. Opera
Bouffe ise 19. yy. Fransız bestecilerinden J. Offenbach’ın tasarladığı özel bir
türdür. Bestecinin Güzel Helen Opereti opera bouffe tarzında yazılmıştır.
Konusu, Troya Savaşı döngüsünün başlangıcında yer almaktadır. Tarih boyunca
Helen karakteri, Halk Ozanı Homeros’tan, Sofist Gorgias’a kadar birçok anlatıma
konu olmuştur. Mitolojide önemli bir yer taşıyan Paris’in Helen’i kaçırma
efsanesi, Offenbach’ın bu yapıtında parodiye dönüşmektedir. Besteci bu
yapıtında hem çağdaş toplumu hem de antik dönemi yermektedir. Akılda kalıcı
melodileri, mizahi olmasının yanı sıra içerdiği sıra dışı lirizm, müzik ve
libretto arasındaki uyum, besteciyi başarıya ulaştıran önemli unsurlardandır. Nitel araştırma yöntemi kullanılarak yapılan araştırmada
eserin partitürü incelenmiştir. Sanat tarihi kaynakları taranmıştır. Eserde
libretto ve müzik arasında kusursuz bir uyum olduğu, prozodi açısından titiz
davranıldığı, orkestrasyonun öncelikli olarak sözlerin duyulmasına imkân
vermesi üzerine inşa edilmiş olduğu sonuçlarına varılmıştır.