bluuebunny/crossref_metadata_2025 huggingface dataset:
RESORT PANTAI GEDAMBAAN KABUPATEN KOTABARU
Authors: Ady Saputra Muhammad Reza , Andini Dila Nadya
Published: April 2024

The beach is a very interesting tourist attraction. Coastal tourism is one of the characteristics possessed by the Kotabaru Regency. Gedambaan Beach is a tourist attraction located in Sarang Tiung Village, Pulau Laut Timur District, Kotabaru Regency. The beautiful natural potential is certainly an attraction for tourists to visit Gedambaan Beach. To attract more tourists, it must be supported by adequate infrastructure, one of which is a resort. The resort is needed to support the increase in visitor growth in Gedambaan Beach where the resort's long visit by tourists will affect local income which will indirectly improve the economy in the surrounding area. The problem of designing the Gedambaan Beach resort is how to design a resort that develops the potential of the region by forming a character based on the concept of contextual architecture in the Gedambaan Beach Resort area. To solve the problem, the Harmony Contextual Method is used. This method emphasizes the design by utilizing the natural potential that is applied to the design aspects of the characteristics, environment, and cultural approach to the design of this resort.
LAPANGAN TEMBAK WASAKA DI BANJARMASIN
Authors: Maulida Aulia Noor , Heldiansyah JC
Published: April 2024

South Kalimantan for the past 10 years has shooting athletes that have the potential to compete national and international. But it is not balanced with facilities such as there is no shooting range that can accommodate all training activities of athletes. Training is the most important thing in achievement, but in fact, the current place for training does not support athletes to maximize their potential. Behavior architecture as a method to solve or maximize the potential of athletes starts with three parts of training: emotion, cognition, and performance. Wasaka Shooting Range designed to make athletes as main users have trained with metamorphosis concepts that prepare the athletes emotionally and cognitively. With this concept, the area is divided into three zones which is the transition, prepare, and main zone.
PENATAAN KORIDOR KAWASAN SEKUMPUL MARTAPURA SEBAGAI WISATA RELIGI
Authors: Hadi Meidina Kartika , Sarbini Gusti Novi
Published: April 2024

Sekumpul, Martapura is acknowledged as a religious tourism destination by Banjar District’s Department of Tourism. Its number of visitors increase rapidly each year, crowding the streets especially in Martapura and Banjarbaru. Yearly, monthly, and even weekly events attract a lot of pilgrims, which boost the economic sector of the local community. This location, which was popularized by K.H. Abdul Ghani (also known as Guru Sekumpul)  has now been filled with many activities. Unfortunately, the physical condition of Sekumpul can no longer accommodate the locals nor the pilgrims. The problem of traffic jams, discomfort and unsafety of pedestrians, and even the dryness of the area must be given solutions so that existing facilities will not go to waste. To solve these problems, the “walkable place” concept is applied, which uses the “sense of place” method with its 3 aspects (form, image, and activities). The walkable place concept is considered suitable and applicable for Rearrangement of Sekumpul Corridor, Martapura, solving problems of the physical conditions by road widening while still considering the existing conditions, adding amenities, creating positive spaces, optimizing the potential of the religious and commercial sectors, and also strengthening Sekmpul’s sense of place. The identity and character already formed in Sekumpul cannot be ignored and changed, therefore this design conserves while also developing for the good of the users.
BANJARMASIN YOUTH DEVELOPMENT CENTER
Authors: Larasati Ajeng , Sarbini Gusti Novi
Published: April 2024

Homeless children are unique and creative individuals. Most of the time these homeless children are based in the city center, however, they are often marginalized from the limelight. The homeless children need to be given the opportunity and the choice to improve their potential. The street corners of Banjarmasin are not the ideal home for these children. The Youth Development Center is the place to develop the potential of homeless children through creative fields with a sense of home in the design. It will be the hub for these children to express themselves through their creations and receive the opportunity to learn more without the space restriction. The Youth Development Center can also be a place for society to appreciate the homeless children’s potential. The design strategy uses the Third Place method as a space for interaction and solution of problems using the concept of Flexible Architecture so that space is defined not only by its function but by the potential of the space itself.
RUMAH SINGGAH KUCING DI BANJARMASIN
Authors: Permadi Fajar , Oktaviana Anna
Published: April 2024

The population of cats is increasing every year in the world, unfortunately, the increase in cat population is also directly proportional to the number of cases of abuse that occur. It is proven that in Banjarmasin itself there are still many acts of persecution, both intentionally and unintentionally. Responding to these problems created an abandoned cat shelter. The Design of Cat Shelter Houses in Banjarmasin is a facility that aims to meet the physical and psychological needs of cats by adopting an environmentally friendly design approach. The concept approach uses Paola Sassi's sustainable architecture, as a solution to problems with land use, health, material, energy, and water strategies, so healthy building designs that benefit residents.
TAMAN BUGAR UNTUK REMAJA DI BANJARBARU
Authors: Amelia Rizky Noor , Wastuty Prima Widia
Published: April 2024

The Movement Park for Youth in Banjarbaru is a park designed as thematic park which focused at physical health that aiming to educating and to increase the youth’s interest for developing physical activity and could be an innovation for delightful destination for youth. The design of movement park is because the lack of interest and care about youth health that focusing on physical activity as a problem. The concept to solve problem is ‘Movement’ which has an aspect about physical activity those are easy, medium, and hard physical activity.
Overhead spray water treatment as a mitigation strategy to alleviate vine stress and safeguard grape quality during heatwaves
Authors: Wilson Alena , Dizy Marta , Dominguez Deolindo , De Rosas Maria Inés , Baldo Yesica , Garcia Luciana , Gargantini Raquel , Deis Leonor , Martinez Liliana
Published: April 2024

Changes in climate are influencing the quality of wine grapes worldwide. The impact of extreme climate events over short periods is increasingly recognised as a serious risk to grape quality and yield quantity. In this study, the mitigation effects of a pulsed water spray treatment on vine canopy during heatwave (HW) events were evaluated in relation to vine condition during the growing season and grape quality. In the UNCuyo experimental vineyard, vines of the three cultivars Malbec (ML), Bonarda (BO) and Syrah (SY) were treated with an overhead pulsed water spray. Heatwaves were defined as days with a minimum temperature of 21 °C and a maximum temperature of 35 °C. Two heat waves were identified during the growing season. Samples were collected at weekly intervals from veraison to harvest. On five sample dates, Leaf and Stem Water Potential (LWP, SWP), Stomatal Conductance (gs), Leaf Temperature (LT), Berry Temperature (BT), Chlorophyll Content (CC), Fluorescence (Fv/Fm) and Performance Index (PI) were recorded at several time points during the day to evaluate the physiological responses of the vine. Berries were collected on each sample date and at harvest. Berry weight, soluble solid content and pH were recorded. In the treated vines (Trt), LWP, SWP, Fv/Fm, PI and gs were significantly higher and LT was lower than in the control vines (Ctl) during the second heatwave, which was longer and more intense than the first one. One week after the more severe heatwave, LWP, SWP and gs remained significantly higher in Trt than in Ctl, displaying reduced physiological stress in Trt. At harvest, the anthocyanin profile, total polyphenol index (TPI), fruit yield, number of bunches and their average weight, berry weight, soluble solid content and pH were also recorded. Bunch weight was significantly higher in Trt for all cultivars. No differences were found in total anthocyanin concentration. These findings indicate that the vines subjected to targeted overhead water treatment during heatwaves underwent less physiological stress and yielded higher grape production, without increasing the risk of potential fungus diseases, in the Mendoza climate. Consequently, this practice could serve as a valuable strategy for mitigating the adverse effects of heatwaves.
Kemampuan Pemecahan Masalah pada Pembelajaran Matematika: Systematic Literature Review
Authors: Siswanto Eko , Meiliasari Meiliasari
Published: April 2024

Kemampuan dalam menyelesaikan masalah adalah keahlian individu dalam melakukan analisis, prediksi, penalaran, evaluasi, dan refleksi dengan memanfaatkan pengetahuan sebelumnya untuk mengatasi tantangan yang dihadapi demi mencapai tujuan yang diinginkan. Tujuan dari penelitian ini adalah untuk menjelaskan kemampuan pemecahan masalah dalam pembelajaran matematika di tingkat pendidikan dasar, menengah, dan menengah atas yang dilakukan antara tahun 2016 hingga 2023. Penelitian ini menggunakan metode Systematic Literature Review (SLR) terhadap semua artikel hasil penelitian kualitatif atau kuantitatif yang terindeks dalam Google Scholar, Sinta, dan Scopus. Strategi pencarian artikel disesuaikan dengan kriteria inklusi dan mengikuti protokol PRISMA sebagai pedoman instrumen penelitian. Dari hasil pencarian, ditemukan 16 artikel yang sesuai dengan kriteria. Hasil penelitian menunjukkan bahwa kemampuan pemecahan masalah merupakan elemen penting dalam kurikulum pembelajaran matematika untuk memungkinkan siswa mengatasi masalah, memperoleh pengalaman, dan menggunakan pengetahuan serta keterampilan yang dimiliki dalam konteks kehidupan sehari-hari. Salah satu model atau strategi yang sering digunakan dalam pembelajaran matematika adalah Model Pemecahan Masalah Polya. Model pembelajaran yang efektif dalam meningkatkan kemampuan pemecahan masalah adalah model Pembelajaran Berbasis Masalah (Problem Based Learning), karena model ini menyediakan lima langkah yang dapat membimbing siswa dalam memecahkan masalah, yaitu: (1) mengorientasikan siswa pada masalah, (2) mengorganisir siswa untuk belajar, (3) membimbing penyelidikan individu dan kelompok, (4) mengembangkan dan menyajikan hasil karya, dan (5) menganalisis serta mengevaluasi proses pemecahan masalah.
Pengaruh Model Pembelajaran CORE dengan Pendekatan Scientific terhadap Kemampuan Berpikir Kritis Matematis SMP Paramarta Unggulan
Authors: Herlina Nofita  , Wijayanti Dwi Antari , Santi Vera Maya
Published: April 2024

Kemampuan penting yang harus dimiliki siswa salah satunya adalah kemampuan berpikir kritis matematis. Kemampuan tersebut dapat ditingkatkan melalui penerapan model dan pendekatan pembelajaran yang tepat. Salah satu model dan pendekatan pembelajaran yang dapat meningkatkan kemampuan berpikir kritis matematis siswa adalah model pembelajaran CORE dengan pendekatan scientific. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran CORE dengan pendekatan scientific terhadap kemampuan berpikir kritis matematis siswa. Metode yang digunakan dalam penelitian ini adalah motode quasi experiment dan desain penelitiannya yaitu Posttest Only Control Group Desain. Teknik pengambilan sampel yang digunakan yaitu teknik cluster random sampling. Kelas yang terpilih sebagai sampel yaitu kelas VIII-1 dan VIII-2 SMP Paramarta Unggulan. Instrumen penelitian terdiri dari 4 soal tes kemampuan berpikir kritis matematis yang berbentuk uraian pada materi fungsi linear. Data hasil penelitian dianalisis menggunakan uji normalitas, uji homogenitas, uji hipotesis-t, dan uji besar pengaruh. Berdasarkan uji hipotesis-t diperoleh  dan  sehingga nilai  maka  ditolak. Oleh karena itu, penerapan model pembelajaran CORE dengan pendekatan scientific memberikan pengaruh yang signifikan terhadap kemampuan berpikir kritis matematis siswa. Hasil perhitungan menggunakan uji Cohen’s Effect Size menunjukkan bahwa model pembelajaran CORE dengan pendekatan scientific memberikan pengaruh terhadap kemampuan berpikir kritis matematis siswa sebesar 69%.
Apatite Triple Dating (Lu–Hf, U–Pb, FT) Constrains Deformation and Cooling in the Coompana and Madura Provinces, Western Australia
Authors: Bedoya Alejandra , Glorie Stijn , Hand Martin , Kirkland Christopher L. , Kelsey David E. , Nixon Angus , Fraser Geoff
Published: April 2024

Combined apatite Lu–Hf, U–Pb, and fission track (AFT) triple dating affords the opportunity to investigate the ~60 and 730°C thermal history of a study area. Here, we apply apatite triple dating to resolve the tempo of multiple thermo-tectonic events within the Precambrian basement rocks of the Coompana (COP) and Madura (MAP) Provinces, Western Australia. Apatite Lu–Hf dates for the western COP (~1.52 Ga) and MAP (~1.36 Ga) agree with published Mesoproterozoic magmatic crystallization ages. Younger apatite U–Pb dates (~1.16–1.12 Ga) for the western COP and MAP suggest isotopic decoupling and radiogenic-Pb loss by volume diffusion in response to metamorphism at that time. Further East in the COP, the apatite Lu–Hf, and U–Pb dates are within uncertainty of each other and are interpreted to reflect recrystallization at ~1.20–1.14 Ga, coinciding with the late Mesoproterozoic Maralinga thermomagmatic event. The imprints of such an event were more pervasive towards the eastern COP, resulting in a thermally weakened crust in this area. AFT results constrain the subsequent Phanerozoic low-temperature history which has contrasting thermal trajectories on either side of the Mundrabilla Shear Zone (MSZ). Thermal history modeling suggests an early Carboniferous rapid cooling pulse (~360–330 Ma) for the COP, east of the MSZ, that is contemporaneous with the intraplate Devonian–Carboniferous Alice Springs Orogeny. In contrast, the MAP, west of the MSZ, records a protracted monotonic cooling history since the Middle Devonian, implying long-term crustal stability. The differences in low-temperature thermal histories may be preconditioned by the extent of thermal weakening during the late Mesoproterozoic, as indicated by the Lu–Hf and U–Pb results. Here, we show the value of apatite triple dating applied to grains recovered from drill core samples, demonstrating opportunities for understanding other poorly accessible terranes.
Paleogene Sedimentary Basin Development in Southern Nevada, USA
Authors: Lundstern Jens-Erik , Schwartz Theresa M. , Mercer Cameron M. , Colgan Joseph P. , Workman Jeremiah B. , Morgan Leah E.
Published: April 2024

The cause of the transition from Mesozoic and early Cenozoic crustal shortening to later extension in the western United States is debated. In many parts of the extant Sevier hinterland, now the Basin and Range Province, the sedimentary sections that provide the most direct record of that transition remain poorly studied and lack meaningful age control. In this paper, we present field characterization supported by U-Pb detrital zircon and 40Ar/39Ar feldspar ages for ten sections across southern Nevada. We describe a newly identified basin, here named the Fallout Hills basin, which preserves >1.0 km of sedimentary deposits as old as middle Eocene, ca. 48 Ma. Deposition occurred during the 20 m.y. (million years) before the 27.60 ± 0.03 Ma Monotony Tuff blanketed much of south-central Nevada, based on 47.6 Ma and younger detrital zircon maximum depositional ages (MDAs) from near the Pintwater and Spotted Ranges. Elsewhere in southern Nevada, prevolcanic Cenozoic strata commonly form thinner (~100 m), isolated exposures that yield detrital zircon MDAs ≤10 m.y. older than (and in some cases essentially the same age as) the ca. 27–28 Ma ignimbrites that cap the sections. A variable but overall upward-fining facies pattern is observed in both the Fallout Hills basin and the thinner sections. These localized patterns imply topographic changes that are unlikely to reflect plate-scale processes and are not consistent with large-magnitude extension. Instead, variable uplift due to magmatism combined with antecedent topographic relief from thrust faulting and subsequent erosion likely provided accommodation for these deposits.
Continental Arc Accumulation Mafic Rocks in the Mid-Upper Crust: Constraints From the Early Eocene Hornblende Gabbro–Diorite in the Tengchong Block, Southeastern Extension of Tibet
Authors: Wen Tai , Zhao Shao-wei , Fang Xiao-yu , Pei Xian-Zhi , Li Zuo-Chen , Chen Jing-Yuan
Published: April 2024

Magmatic activity in the syn-collision stage is key for net crustal growth. To understand the mechanism of accretion–differentiation and compositional change of the continental crust, it is important to focus on the magmatic activity during the syn-collision stage. Early Eocene mafic–ultramafic rock assemblages found in the western part of the Tengchong Block resulted from a continuous series of arc magmatic evolution, thoroughly recording the continental arc magmatic system during the subduction of the Neo-Tethys Ocean and syn-collision of the Indian-Asian continents. Early Eocene hornblende gabbro–diorite in the Tengchong Block formed at 53 Ma, and the primitive magma was derived from an enriched mantle source due to the enriched Nd–Hf isotopes. The amphibole and biotite thermobarometer measurements indicate that the mafic magma reservoirs in the Tengchong Block occurred at a mid-upper crust. Petrography, amphibole Fe/Mg exchange coefficient (KD), Rayleigh fractionation, and equilibrium melt calculation indicate that the Early Eocene hornblende gabbro–diorite in the Tengchong Block was created due to plagioclase-dominated accumulation at the mid-upper crust level. Based on the calculation, the corresponding amphibole equilibrium melt is more silicic (dacitic–rhyolitic in composition) than the bulk rocks, indicating a more evolved composition in the mid-upper crust. Three types of plagioclases reveal the multi-recharging and dissolution–reprecipitation promoting the further evolution of these mafic rocks. Therefore, this study concludes that magma recharge and plagioclase-dominated accumulation processes may be important mechanisms for the formation and evolution of mafic magma and the further crustal differentiation at the mid-upper crust level in a continental margin arc.
Numerical Modeling of Melting Processes During Slab Break-off: Insights Into Tectonic Setting for Massif-Type Anorthosites
Authors: Yuan Qian
Published: April 2024

The concept that lithosphere detachment or break-off has long been conceived as a viable mechanism to explain prominent geological phenomena in Earth’s crust and the surface. One of the strengths of slab delamination mechanism is that it can account for the extensive magmatism in active orogenic belts due to the upwelling of the asthenosphere after the slab break-off. However, in the last 20 years, geodynamic simulations show that the inflow of the asthenosphere upon slab break-off is insufficient to cause significant melting of the overriding lithosphere adjacent to the slab window. The primary reasons include the occurrence of slab break-off at a location that is too deep to effectively heat the overriding lithospheric mantle. Another factor is the presence of a thin film of crustal material that is retained during the slab break- off, inhibiting a significant thermal perturbation within the lithosphere. In this work, we couple petrological–thermomechanical simulations with magmatic melting processes to examine the lithospheric melting and surface lithological expression associated with slab break-off. Our work shows that in the early Earth when the mantle temperature is relatively higher, shallow slab break-off can give rise to significant lithospheric melting during the development of slab break-off. Moreover, because the slab becomes weaker in the earlier hotter mantle, it may break-off prior to the stage of continental collision, thus the magmatism it induced may not give a direct constraint on the time of continental collision. Our study has implications for the interpretation of geological and tomography studies in orogenic belts. It also provides insights into reconciling conflicts between geodynamic and geological studies regarding slab break off-induced melting and magmatism.
Axial Load Peristaltic Transfer Mechanism of the Drillstring to Improve Penetration Rate
Authors: Wang Peng , Cao Jifei , Zhang Heng , Yue Weimin , Ni Hongjian , Zhang Rui
Published: April 2024

During the drilling of long horizontal wells, the significant frictional resistance generated by the wellbore walls poses a challenge for the drillstring to efficiently transmit load to the drill bit, which eventually reduces drilling efficiency and restricts the extension distance achievable. Inspired by the structure and movement principle of an earthworm, we propose an earthworm-like load transfer method for the drillstring to address this issue. Specifically, the proposed method involves the installation of a pulse generator and multiple vibration subs within the same drillstring, decomposes the drillstring into multiple sections and modulates it to creep like an earthworm, thus facilitating load transfer. Experimental studies and numerical simulations were conducted in this paper to explore the fundamental mechanisms of earthworm-like crawling, aiming to enhance the efficiency of load transfer within the drillstring. The experimental results suggest that adopting earthworm-like excitation can increase the load transfer efficiency of the drillstring by 36–52% compared to conventional drilling methods. However, if the drillstring experiences helical buckling, there is a significant decrease in the efficiency of load transfer. Meanwhile, a dynamic model of the drillstring, considering the 3D wellbore trajectory, multipoint excitation, Stribeck friction, and penetration rate, has been developed. The simulated results from the proposed model align well with the experimental results obtained before the drillstring buckling, with an error of less than 5%. The simulation results for a 1000-m drillstring indicate that the earthworm-like excitation significantly enhances the efficiency of load transfer compared to conventional drilling methods. This improvement is attributed to the increase in the proportion of reverse-motion drillstring segments by 35.8–40.25%, which will greatly reduce the instantaneous total vector frictional force of the entire drillstring.
Harnessing Voice Analysis and Machine Learning for Early Diagnosis of Parkinson's Disease: A Comparative Study Across Three Datasets
Authors: Neto Osmar Pinto
Published: April 2024

Objective
This study evaluates the efficacy of voice analysis combined with machine learning (ML) techniques in enabling the diagnosis of Parkinson's Disease (PD).
Methods
Voice data, phonation of the vowel 'a', from three distinct datasets (two from the UCI ML Repository and one from figshare) for 432 participants (278 PD patients) were analyzed. We employed four ML models - Artificial Neural Networks (ANN), Random Forest (RF), Gradient Boosting (GB), and Support Vector Machine (SVM) - alongside two ensemble methods (soft voting classifier - EVC and stacking method - ESM). The models underwent 50 iterations of evaluation, involving various data splits and 10-fold cross-validation. Comparative analysis was done using one-way ANOVA followed by Bonferroni post hoc corrections.
Results
The ESM, SVM, and GB models emerged as the top performers, demonstrating superior performance across metrics, including accuracy, sensitivity, specificity, precision, F1 score, and ROC AUC. Despite data heterogeneity and variable selection limitations, the models showed high values for all metrics.
Conclusion
Machine learning integration with voice analysis, mainly through ESM, SVM, and GB, is promising for early PD diagnosis. Using multi-source data and a large sample size enhances our findings' validity, reliability, and generalizability.
Cheatgrass alters flammability of native perennial grasses in laboratory combustion experiments
Authors: Harrison Georgia R. , Jones Lisa C , Ellsworth Lisa M , Strand Eva K. , Prather Timothy S.
Published: April 2024

Background
The invasive annual grass cheatgrass (Bromus tectorum) increases fuel continuity, alters patterns of fire spread, and changes plant communities in sagebrush shrublands of the Great Basin (USA) and adjacent sagebrush steppe areas, but no studies have contrasted its flammability to native perennial grasses. Understanding cheatgrass flammability is crucial for predicting fire behavior, informing management decisions, and assessing fire potential of invaded areas. This study aimed to determine the flammability of cheatgrass compared to two native perennial grasses (Columbia needlegrass [Achnatherum nelsonii] and bluebunch wheatgrass [Pseudoroegneria spicata]) across a range of typical fire season fuel moistures.
Results
All three grass species had decreased flammability with increasing fuel moisture. Columbia needlegrass had on average 11% lower mass consumption than cheatgrass, and both perennial grasses had on average 13.5 s longer flaming durations and higher thermal doses (temperature over time) than cheatgrass. The addition of cheatgrass to the perennial grasses increased combined mass consumption, flaming duration, and thermal dose. For these three attributes, flammability increased with greater amounts of cheatgrass in the mixture, but flaming duration and thermal dose were not sensitive to cheatgrass fuel moisture. Maximum temperature and flame length of perennial grass combustion were similar with and without cheatgrass addition. Flammability of Columbia needlegrass when burned with cheatgrass was higher than expected based on the flammability of each respective species, suggesting that Columbia needlegrass may be susceptible to pre-heating from cheatgrass, causing increased mass consumption, flaming duration, and thermal dose. Conversely, flammability of bluebunch wheatgrass and cheatgrass together had both positive and negative interactive effects.
Conclusions
This study provides experimental evidence supporting previous qualitative observations of high cheatgrass flammability. Even at high fuel moisture, cheatgrass increased perennial grass flammability, suggesting that cheatgrass poses a significant fire threat to native grasses for an extended season than expected for the native grasses without cheatgrass. The study's findings inform invasive plant management and fire potential, and guide efforts to prevent or mitigate cheatgrass-induced wildfires.
Physical formula enhanced multi-task learning for pharmacokinetics prediction
Authors: Li Yuqiang , Li Ruifeng , Zhou Dongzhan , Shen Ancheng , Zhang Ao , Su Mao , Li Mingqian , Chen Hongyang , Chen Gang , Zhang Yin , Zhang Shufei , Ouyang Wanli
Published: April 2024

Artificial intelligence (AI) technology has demonstrated remarkable potential in drug discovery, where pharmacokinetics plays a crucial role in determining the dosage, safety, and efficacy of new drugs. A major challenge for AI-driven drug discovery (AIDD) is the scarcity of high-quality data, which often requires extensive wet-lab work. A typical example of this is pharmacokinetic experiments. In this work, we develop a physical formula enhanced multi-task learning (PEMAL) method that predicts four key parameters of pharmacokinetics simultaneously. By incorporating physical formulas into the multi-task framework, PEMAL facilitates effective knowledge sharing and target alignment among the pharmacokinetic parameters, thereby enhancing the accuracy of prediction. Our experiments reveal that PEMAL significantly lowers the data demand, compared to typical Graph Neural Networks. Moreover, we demonstrate that PEMAL enhances the robustness to noise, an advantage that conventional Neural Networks do not possess. Another advantage of PEMAL is its high flexibility, which can be potentially applied to other multi-task machine learning scenarios. Overall, our work illustrates the benefits and potential of using PEMAL in AIDD and other scenarios with data scarcity and noise.
Calculation of Drag Coefficient and Friction Factor of Non-Submerged Rigid Vegetation in Symmetric Compound Channel, Using Direct Measurement Method
Authors: Maturi Foad , Askar Mehdi Behdarvandi
Published: April 2024

Given that the most basic issue in the study of drag coefficient is the correct and accurate measurement of force, so the use of a method that can directly measure the force of flow is very important because it can provide a more realistic analysis of drag coefficient. Also, the results obtained from this method are compared with the results obtained from other methods .This research has calculated the drag coefficient and friction factor using the direct measurement method and physical modeling in a hydraulic knife-edge flume, which is a particular type of flume capable of directly measuring the flow force. In this study, five vegetation diameters, 20, 25, 30, 40, and 50 mm, as well as two types of ordered and non-ordered arrangement, and three vegetation positions in floodplains, main channel and simultaneously vegetation in main channel and floodplain, considering five inline spacing, and three Cross line spacing between vegetation, which included a total of 451 different experiments, were examined. In this paper, the value is between 0.0017-0.31, and the vegetation's Reynolds number is in the range 3512-29213. The results revealed that the method and calculations implemented in the field of drag coefficient are suitably similar to the drag coefficient obtained from the force balance equation; moreover to calculate drag coefficient and friction factor in the examined scope, and were achieved based on the vegetation parameter . The coefficients of considering the experiments and different position and arrangement of vegetation were presented.
Stiffness characteristics of angular contact ball bearing considering thermal - mechanical coupling
Authors: gao chen , xu tao , chen yu li , chen tao , zhang shou jing
Published: April 2024

When the rotor is rotating at high speed, the ball bearing stiffness exhibits strong nonlinear characteristics. This paper primarily investigates the influence of different speeds, axial loads, and other factors on the angular contact ball bearing stiffness. To address the inconvenience of simultaneously simulating dynamic temperature fields and deformation results using ANSYS software, a novel coupling method is proposed to achieve simulation results that closely resemble actual working conditions. By utilizing a MATLAB script program based on Palmgren's friction heat generation theory, real-time extraction of frictional heat generation in high-speed angular contact ball bearings under combined shaft action, radial load, and speed is achieved. The obtained heat generation results are then applied as boundary conditions in the finite element model of bearings to establish a coupling field for further analysis. Subsequently, Ansys Workbench simulates the impact of this coupling model on relative displacement between inner and outer rings under identical load and speed conditions to ultimately obtain dynamic stiffness results for angular contact ball bearings. A novel approach to calculating stiffness was introduced in the subsequent bearing stiffness test bench, wherein the radial load and relative displacement of the measured angular contact ball bearing were determined by converting material mechanics formulas. This method effectively addresses the inconvenience of measuring bearing stiffness in rotor systems and aligns with simulation results.The findings indicate that bearing dynamic stiffness increases with axial load at constant speed, with axial stiffness being greater than radial stiffness. Additionally, higher rotational speeds under coaxial loads result in more pronounced increases in frictional heat but lead to decreased overall stiffness. The feasibility of simulation results from thermal-mechanical coupling models has been demonstrated.
ActivinA modulates B-Acute Lymphoblastic Leukaemia cell communication and survival by inducing extracellular vesicles production
Authors: Licari Eugenia , Cricrì Giulia , Mauri Mario , Raimondo Francesca , Dioni Laura , Favero Chiara , Giussani Alice , Starace Rita , Nucera Silvia , Biondi Andrea , Piazza Rocco , Bollati Valentina , Dander Erica , D'Amico Giovanna
Published: April 2024

Extracellular vesicles (EVs) are a new mechanism of cellular communication, by delivering their cargo into target cells to modulate molecular pathways. EV-mediated crosstalk contributes to tumor survival and resistance to cellular stress. However, the role of EVs in B-cell Acute Lymphoblastic Leukaemia (B-ALL) awaits to be thoroughly investigated. We recently published that ActivinA increases intracellular calcium levels and promotes actin polymerization in B-ALL cells. These biological processes guide cytoskeleton reorganization, which is a crucial event for EV secretion and internalization. Hence, we investigated the role of EVs in the context of B-ALL and the impact of ActivinA on this phenomenon. We demonstrated that leukemic cells release a higher number of EVs in response to ActivinA treatment, and they can actively uptake EVs released by other B-ALL cells. Under culture-induced stress conditions, EVs coculture promoted cell survival in B-ALL cells in a dose-dependent manner. Direct stimulation of B-ALL cells with ActivinA or with EVs isolated from ActivinA-stimulated cells was even more effective in preventing cell death. This effect can be possibly ascribed to the increase of vesiculation and modifications of EV-associated microRNAs induced by ActivinA. These data demonstrate that ActivinA boosts EV-mediated B-ALL crosstalk, improving leukemia survival in stress conditions.
Adenoid Cystic Carcinoma of the Breast: A Case Report
Authors: Hercules Jose
Published: April 2024

Adenoid cystic carcinoma is a rare form of breast cancer accounting for 0.1%-1.0% of all mammary cancer malignancies. Breast cancer is characterized by an indolent clinical course and favorable prognosis, contrary to other breast cancers. Diagnostic mammogram and breast ultrasound play a pivotal role in the early detection and diagnosis of breast adenoid cystic carcinoma. Treatment may consist of lumpectomy and radiation therapy vs mastectomy alone. Although rare, late disease recurrence and metastasis have been reported in the literature; thus, long-term surveillance is of utmost importance for these patients. We will review the literature and discuss the case of a 52-year-old female who presented with a palpable lump of the right breast, which was pathologically proven to be adenoid cystic carcinoma of the breast.
Enhanced formation of nitrogenous organic aerosols and brown carbon after aging in the planetary boundary layer
Authors: Liu Dantong , Wu Yangzhou , Liu Quan , Tian Ping , Xu Weiqi , Wang Junfeng , Hu Kang , Li Siyuan , Jiang Xiaotong , Wang Fei , Huang Mengyu , Ding Deping , Yu Chenjie , Hu Dawei
Published: April 2024

Particulate organic nitrates (pON) significantly contribute to the mass of organic aerosol and influence the NOX cycle in the atmosphere, but their evolution and lifetime remain uncertain. This study performed simultaneous measurements on the anthropogenically affected surface site and the mountain site on top of the polluted planetary boundary layer (PBL). After aging in the PBL, organic nitrate was converted from primary sources (decreased from 8.7 % to 4.3 %) to secondary sources (increased from 6.3 % to 36.1 %), spanning from the surface to the mountain. The evaporation of more volatile inorganic nitrate and the production of secondary organic nitrate during aging in the PBL contributed to the enhanced pON fraction over the top of PBL. The contribution of light absorption by brown carbon increased by 43 % at the top of PBL compared to the surface, consistent with the higher fraction of nitrogenous organic aerosols over the mountain. The results provide field evidence that the nitrogenous OA may be preserved by adding into secondary OA and significantly contribute to the enhanced importance of brown carbon after aging the vertical transport in the PBL.
Effective removal of Eriochrome black T by a novel ZnxCu01-xFe2O4/C3N4 composite under simulated visible light irradiation
Authors: Liu Zhixiong , Liu Jiaqi , Hu Yiting , Tian Yuhang , Li Fei , Xian Yanhong
Published: April 2024

A new ZnxCu1−x Fe2O4/C3N4 composite was successfully prepared through a precipitation-assisted calcining technology. The characterization of the as-synthesized catalysts was performed using various analytical techniques. When compared with pure g-C3N4, pristine ZnFe2O4 and bare CuFe2O4, the ZnxCu1−xFe2O4/g-C3N4 composite exhibits higher photo-catalytic degradation of Eriochrome black T (EBT) under a visible light irradiation. When the molar ratio of Zn/Cu (1/1) and the mass ratio of ZnxCu01−xFe2O4 (50%) in the hybrid nanocomposite, ZnxCu1−xFe2O4/g-C3N4 composite exhibits high EBT removal efficiency of 99.73% by adding sodium persulfate (SPS) in waste water within 120 min of the photocatalytic degradation experiment. Enhanced the visible light absorption ability and the suppression of photoexcited charge carriers is also achieved by forming heterojunctions between Zn0.5Cu0.5Fe2O4 and g-C3N4. The Zn0.5Cu0.5Fe2O4/g-C3N4 exhibited 2.91 times higher degradation efficiency than Zn0.5Cu0.5Fe2O4 nanoparticles and 1.96 times higher degradation efficiency than g-C3N4. The trapping experiments were performed by adding different eliminating agents and it shows that the photodegradation of EBT was mainly caused by electron hole (h+), superoxide ion(·O2−) and sulfate radical (·SO4−). Among these resctive species, electron holes (h+) are the predominant reactive species. This study provided a promising approach for the treatment of contaminated water using ZnxCu1−xFe2O4/g-C3N4 as a photocatalyst.
Study the effect of Zn2SnO4/ZnO/SnO2 on the structural, optical, and electrical properties of PVA nanocomposites for promising applications
Authors: Saadeldin M. M. , Samir Ahmed , Desouky Fawzy G. El
Published: April 2024

This study details the successful incorporation of zinc tin oxide nanoparticle (ZTO-NPs) into polyvinyl alcohol (PVA) using the hydrothermal method. We introduce a streamlined and integrated synthesis approach, representing a novel direction for polymeric composite films with wide-ranging applications. This was achieved by creating a nanocomposite in a PVA matrix using ZTO-NPs composite as a filler at different concentrations that can be extended to use in many applications, such as optoelectronics. The study delves into the impact of ZTO-NPs loadings on the optical, electrical, and structural properties of PVA films across different concentrations. Structural analysis of ZTO-NPs and resulting ZTO/PVA nanocomposite films is performed using X-ray diffraction (XRD), while Fourier transform infrared (FT-IR) analysis confirms the interaction between ZTO-NPs and PVA. Atomic force microscopy (AFM) is employed to analyze surface morphology and roughness, while diffuse reflectance spectroscopy (DRS) reveals enhanced UV absorption and a red-shift with increased ZTO-NPs concentration. Moreover, the optical band-gap decreases with higher ZTO-NPs concentration. Electrical properties, including dielectric constant, dielectric loss, conductivity, and electric modulus, are investigated at room temperature across different frequencies, indicating an increase in dielectric constant with ZTO-NPs concentration.
WITHDRAWN: Parental Nutrition Literacy, Dental Anxiety and Children's Oral Health-Related Quality of Life: A Close Look
Authors: GONUL Busra ASLAN , CICEK Betul
Published: April 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Fungal Argonaute proteins act in bidirectional cross-kingdom RNA interference during plant infection
Authors: Weiberg Arne , Cheng An-Po , Huang Lihong , Oberkofler Lorenz , Johnson Nathan R , Salinas Francisco , Wange Lucas , Enard Wolfgang , Glodeanu Stefan-Adrian , Stillman Kyra
Published: April 2024

Argonaute (AGO) proteins bind to small RNAs to induce RNA interference (RNAi), a conserved gene regulatory mechanism in animal, plant, and fungal kingdoms. Small RNAs of the fungal plant pathogen Botrytis cinerea were previously shown to translocate into plant cells and bound to the host AGO, which induced cross-kingdom RNAi to promote infection. However, the role of pathogen AGOs during host infection stayed elusive. In this study, we revealed that members of fungal plant pathogen Botrytis cinerea BcAGO family contribute to plant infection and act in bidirectional cross-kingdom RNAi, from fungus to plant and vice versa. Providing these new mechanistic insights of pathogen AGOs promise to improve RNAi-based crop protection strategies.
Numerical modeling and DFT study for a CsPbCl3 lead-based perovskite solar cell using Zn-doped Cu2O as HTL
Authors: Hachimi Mohamed Amine , Tarbi Amal , El-Mrabet Mariam , Erguig Hassane , Chtouki Tarek
Published: April 2024

In recent years, inorganic perovskite solar cells have attracted increasing interest in the field of photovoltaics. This study focused on the optimization of these cells using CsPbCl3 as the absorber material through extensive simulations using SCAPS-1D software. In addition, first-principles calculations were performed using density functional theory (DFT) to explore the properties of CsPbCl3, such as its structure, energy band, total and partial density of states, and their optical properties. Different ETL layers, such as C60, ZnSe, PCBM, SnO2 and WS2, and an inorganic HTL composed of zinc-doped Cu2O (7%), were evaluated. The results showed that using SnO2 as the ETL yielded the best performance. The study also examined the impact of various critical parameters, such as the thickness and defect density of the absorber layer, donor doping density in this layer, series and shunt resistances, and operating temperatures, on the overall cell performance. The optimum device configuration, FTO/SnO2/CsPbCl3/Cu2O:Zn(7%)/Au, showed a PCE of 24.23%, FF of 88.45%, VOC of 1.567 V, and JSC of 17.48 mA/cm2. The results underline the crucial importance of CsPbCl3 for optical applications, particularly in solar energy conversion, highlighting the considerable potential of this material.
Construction of a predictive model for the risk of sepsis-related liver injury in the intensive care unit: a retrospective cohort study over 10 years
Authors: Lin Hairong , Lin Jiandong , Lin Xinxin , Liao Qiuxia , Zhou Ye , Lin Bingwen , Xiao Xiongjian
Published: April 2024

OBJECTIVE: Sepsis-associated liver injury (SALI) seriously affects the prognosis of patients in the intensive care unit, and there is still a lack of effective predictive tools. The aim of this study was to investigate the independent risk factors of SALI and to establish and validate an effective risk prediction model.
METHODS: Patients diagnosed with sepsis by the Medical Information Marketplace for Intensive Care (MIMIC-IV v2.2) were included. The least absolute shrinkage and selection operator (LASSO) logistic regression was used to identify independent risk factors for developing SALI. Risk prediction models were constructed and column-line plots were drawn. The predictive model was validated using receiver operating characteristic (ROC) curves, Hosmer-Lemeshow (H-L) test and decision curve analysis (DCA).
RESULTS: A total of 8549 sepsis patients were included in the final cohort. There were 4834 males and 3715 females; the mean age of the patients was 66.72 ± 16.18. A total of 1067 (12.48%) patients developed SALI. All patients were randomized into a training cohort and a validation cohort in a 7:3 ratio. The training cohort was analyzed using LASSO logistic regression with the final inclusion of eight indicators used to construct the predictive model: abdominal infection (OR =4.046,95% CI:3.236-5.059, P<0.001), vasopressin (OR=2.188, 95% CI:1.778-2.694 , P<0.001), continuous renal replacement therapy (CRRT) (OR=1.928, 95%CI:1.506-2.469, P<0.001), red blood cell distribution width (RDW) (OR=1.109, 95%CI:1.069-1.151, P<0.001), platelet ( OR=0.996, 95%CI:0.996-0.996, P< 0.001), prothrombin time (PT) (OR=1.042, 95%CI:1.034-1.051, P<0.001), lactate (OR=1.154, 95%CI:1.107-1.202 ,P<0.001) and SOFA score (OR=1.119, 95%CI:1.089-1.150 ,P <0.001). The area under the ROC curve (AUC) of the predictive model was 0.830 (95% CI:0.814-0.847) in the training cohort and 0.847 (95% CI:0.825-0.869) in the validation cohort. The calibration curves were in good agreement with the ideal curves in both the training cohort and the validation cohort. Decision curve analysis (DCA) showed the ability to obtain a net benefit from this model with good clinical applicability.
CONCLUSION: Abdominal infection, vasopressin, CRRT, RDW, platelet, PT, lactate, and SOFA score are independent risk factors for patients with SALI. The SALI prediction model constructed based on the above factors has certain clinical predictive value.
Spatial-temporal characteristics and hazard analysis of compound dry and hot events in N ortheast China
Authors: Li Ying , Liang Jihao , Liu Ziying , Zhang XueLing , Zhu Meiqi
Published: April 2024

Extreme hot and dry weather seriously threatens the human environment and food security in North-east China (NC). Analyzing compound dry and hot events (CDHE) can provide an accurate and targeted scientific basis for high-risk areas. Meteorological data from 108 weather stations between 1961 and 2020 was used to analyze NC compound dry and hot events. Daily maximum temperature, SPI, and duration were used to build a three-dimensional Copula model that analyzed the risk of CDHE. The results showed that the overall trend increased from 1961 to 2020. The frequencies of CDHE decreased from 1961 to 1990; increased from 1991 to 2020, and peaked in 2000. CDHE occurred in 1982, 1997, 2000, 2007, and 2017. The most pronounced increasing trends were observed in climate zones IICTb-c2, IIBTb-c, IICTb-c1, and IATa. The highest frequency and intensity occurred between 1991 and 2010, with a decreasing trend from 2011 to 2020. From 1961 to 2020, 6153 CDHE occurred, with an average duration of 4.7 days, an average temperature of 32.07°C, and an average SPI of -1.27. Moderate-intensity CDHE occurred with the highest frequency, accounting for 49.71% of all the CDHE. The spatial distribution of the frequency of CDHE was biased toward the middle, showing a decreasing trend from east to west. The frequency of CDHE from 1991 to 2020 showed an increasing trend, and high-frequency events gradually shifted to the northwestern part of the study area. The high-risk areas were mainly concentrated in western and central parts in climate zones IIATc-d, IIBTd, IICTb-c2, and IIDTd-e.