bluuebunny/crossref_metadata_2025 huggingface dataset:
The duration of untreated psychosis among U.S. Latinxs and social and clinical correlates
Authors: Santos Maria M. , Kratzer Maya , Zavala Jaqueline , Lopez Daisy , Ullman Jodie , Kopelowicz Alex , Lopez Steven Regeser
Published: April 2023

Purpose

This study (a) documents the duration of untreated psychosis (DUP) and (b) examines both social and clinical correlates of DUP in a sample of U.S. Latinxs with first-episode psychosis (FEP).

Methods

Data were collected for a longitudinal study evaluating a community education campaign to help primarily Spanish-speaking Latinxs recognize psychotic symptoms and reduce the DUP, or the delay to first prescribed antipsychotic medication after the onset of psychotic symptoms. Social and clinical variables were assessed at first treatment presentation. A sequential hierarchical regression was conducted using √DUP to identify independent predictors of the DUP. A structural equation model was used to explore the association between DUP predictors, DUP, and clinical and social correlates.

Results

In a sample of 122 Latinxs with FEP, the median DUP was 39 weeks (M = 137.78, SD = 220.31; IQR = 160.39–5.57). For the full sample, being an immigrant and having self-reported relatively poor English-speaking proficiency and self-reported strong Spanish-speaking proficiency were related to a longer delay to first prescribed medication after psychosis onset. For the immigrant subgroup, being older at the time of migration was related to a longer delay. Self-reported English-speaking proficiency emerged as an independent predictor of the DUP. Although the DUP was not related to symptomatology, it was associated with poorer social functioning. Low self-reported English-speaking ability is associated with poorer social functioning via the DUP.

Conclusion

Latinxs with limited English language skills are especially at high risk for experiencing prolonged delays to care and poor social functioning. Intervention efforts to reduce the delay in Latinx communities should pay particular attention to this subgroup.
The relationship between childhood asthma and socioeconomic status: a Korean nationwide population-based study
Authors: Lee Won Seok , Hwang Jae Kyoon , Ryu Jiin , Choi Young-Jin , Oh Jae-Won , Kim Chang-Ryul , Han Man Yong , Oh In Hwan , Lee Kyung Suk
Published: April 2023

Purpose

This study aimed to investigate associations of socioeconomic status (SES) with asthma exacerbation and asthma-related hospital utilization factors among children with asthma in the Republic of Korea.

Methods

This study retrospectively analyzed population-level data from the Korean National Health Insurance Service, collected from 2013 through 2019. SES was classified into five categories according to the national health insurance premiums quantiles (0 [lowest] to 4 [highest]). The hazard ratios (HRs) for asthma exacerbation, emergency department (ED) visits, hospital admission, and intensive care unit (ICU) admission were analyzed with respect to SES.

Results

Among the five SES groups, SES group 0 (medical aid), had the highest tallies and proportions of children who experienced asthma exacerbations (n = 1,682, 4.8%), ED visits (n = 932, 2.6%), hospital admission (n = 2,734, 7.7%) and ICU admission (n = 14, 0.04%). Compared with SES group 4, SES group 0 had adjusted HRs of 3.73 (p = 0.0113) and 1.04 (p < 0.0001) for ventilator support/tracheal intubation and administration of systemic corticosteroids, respectively. Relative to group 4, the adjusted HRs for ED visits, hospital admission, and ICU admission in group 0 were 1.88 (p < 0.0001), 2.20 (p < 0.0001), and 7.12 (p < 0.0001), respectively. In the survival analysis, group 0 had a significantly higher risk of ED presentation, hospital admission, and ICU admission than the other groups (log-rank p < 0.001).

Conclusion

Compared with children of higher SES, those in the lowest SES group had increased risk of asthma exacerbation, hospital admission, and receiving treatment for severe asthma symptoms.
Encouraging sustainable mobility: community case study on workplace initiatives in Lahti, Finland
Authors: Villanen Marjut , Vanhamäki Susanna , Hämäläinen Riitta-Maija
Published: April 2023

The transport sector represents about 30 per cent of all carbon dioxide (CO2) emissions in developed countries. Developing sustainable transport and mobility play a central role in reducing greenhouse gas emissions. Sustainable mobility means a mind shift where transport in private cars is replaced by different modes of more sustainable mobility, such as, walking, biking, and public transport. The transformation toward more sustainable mobility plays a key role in reaching CO2 emission reduction goals. However, in addition to the environmental perspective, also social and economic aspects are interconnected in the change. In this sustainability shift, employers can encourage the employees through offering and supporting new alternatives for mobility. This article aims to study how different sustainable mobility initiatives provided by an employer are adopted by employees. This case study presents a set of pilots implemented at a workplace in Lahti, Finland in May-October 2022. The mobility forms offered for commuting were fringe benefits from employment, that is, employer-subsidized commuter tickets and employer-provided bicycle benefits. Travel during the workday was supported through introducing the use of shared electric city bikes and scooters. The research data consisted of short surveys before (n = 70) and at the end of the pilots (n = 66), and thematic interviews (n = 8) during the implementation period. The pilots were implemented in collaboration with the employer and two local universities. Before the pilots, the main part of the employee participants was using private cars for commuting and travel during the workday. Results show that the pilots were successful in introducing more sustainable ways of mobility. However, the employer's role in preparing, supporting, and planning the continuation of support for sustainable commuting and mobility is essential.
Using Microscopy to Look Inside the Brain in Action
Authors: Henschke Julia U. , Pakan Janelle M. P.
Published: April 2023

The brain is the control center for all our thoughts and actions. Have you ever wondered exactly how your brain works as you run, jump, and play? To look inside the working brain, scientists use a combination of high-tech microscopes, lasers, and genetic engineering, which allows them to directly see the cells within the brain—called neurons. Scientists can make neurons glow when those cells become active, which tells scientists the neurons are passing information to each other in large networks. In this way, neurons take in information from the environment and use it to plan your next move. We will discuss the biology, physics, and virtual tools that scientists are using to directly examine the activity of neurons in the brains of mice. The findings from these experiments help scientists understand how neurons work together, how they help us learn and remember, and what goes wrong in disorders that affect the brain.
Perspectives from research and practice: A survey on external load monitoring and bone in sport
Authors: Scott Reece , James Ruth , Barnett Cleveland T. , Sale Craig , Varley Ian
Published: April 2023

Introduction

There is limited information regarding the association between external load and estimated bone load in sport, which may be important due to the influence exercise can have on bone accrual and injury risk. The aim of this study was to identify external load measuring tools used by support staff to estimate bone load and assess if these methodologies were supported in research.

Methods

A survey was comprised of 19 multiple choice questions and the option to elaborate on if/how they monitor external load and if/how they used them to estimate bone load. A narrative review was performed to assess how external load is associated to bone in research.

Results

Participants were required to be working as support staff in applied sport. Support staff (n = 71) were recruited worldwide with the majority (85%) working with professional elite athletes. 92% of support staff monitored external load in their organisation, but only 28% used it to estimate bone load.

Discussion

GPS is the most commonly used method to estimate bone load, but there is a lack of research assessing GPS metrics with bone load. Accelerometry and force plates were among the most prevalent methods used to assess external load, but a lack of bone specific measurements were reported by support staff. Further research exploring how external load relates to bone is needed as there is no consensus on which method of external load is best to estimate bone load in an applied setting.
Effects of workplace stress, perceived stress, and burnout on collegiate coach mental health outcomes
Authors: Wright Simon A. , Walker Lauren F. , Hall Eric E.
Published: April 2023

Introduction

Given the continuously changing job demands of coaches, coach burnout continues to be an important area of study. Coaching literature highlights the role occupational stressors play in the development and management of burnout. However, research highlights the potential need for the field to differentiate feelings of burnout from those of other sub-clinical mental health indicators (e.g., anxiety, depression). This study sought to examine the relationship between workplace stress, perceived stress, coach burnout, coach well-being, and sub-clinical health issues (anxiety, stress, depression).

Methods

One hundred forty-four NCAA collegiate coaches completed online questionnaires measuring the proposed variables. Structural equation modeling was used to test the proposed hypothesis that burnout would serve as a partial mediator between workplace and perceived stress and mental health indicators (e.g., depression, anxiety, stress, and well-being).

Results

Workplace stress and perceived stress were positively associated with both burnout subscales. Additionally, perceived stress alone exhibited a positive association with depression, anxiety, and stress and a negative association with well-being. While there was a positive significant relationship between disengagement and depression in the model and a negative significant relationship between disengagement and well-being, most relationships between the two burnout subscales and mental health outcomes were negligible.

Discussion

It can be concluded that while workplace and perceived life stressors may impact feelings of burnout and mental health indicators directly, burnout does not appear to exhibit a strong effect on perceptions of mental health and well-being. In line with other research studies, it may be worth considering whether burnout should be considered another type of clinical mental health issue instead of as a direct contributor to coach mental health.
Metabolites changes of a low-temperature and low-salt fermented Chinese kohlrabi during fermentation based on non-targeted metabolomic analysis
Authors: Zhao Zhiping , Chen Hongfan , Zhang Yulin , Nie Xin , Xiang Lu , Peng Tao , Liu Dayu , Luo Huailiang , Wang Aili
Published: April 2023

A low-temperature and low-salt industrially fermented Chinese kohlrabi (LSCK) was developed in this study, with the salt usage decreased by approximately 70% compared to the traditional high-salt fermented Chinese kohlrabi (HSCK). The differences in physicochemical properties, metabolites and overall flavors during LSCK fermented for 0, 45 and 90 days (d) were analyzed by gas chromatography-time-of-flight mass spectrometry (GC-TOF-MS), electronic nose (E-nose) and other techniques. The results showed that the total acid content increased significantly from 3.68 to 8.59 g/kg. However, the protein content significantly decreased from 2.52/100 to 0.66 g/100 g. The number of lactic acid bacteria cells increased significantly from 3.69 to 4.46 log10CFU/g. Based on multivariate statistical analysis, 21, 14, and 15 differential metabolites were identified in the three treatment groups A1 (0 and 45 days), A2 (45 and 90 days), and A3 (0 and 90 days) respectively (VIP > 1, p < 0.05, |log2FC| ≥ 1.1). Carbohydrates, sugar alcohols, amino acids and their derivatives were the main differential metabolites in the LSCKs fermented for different periods. Aminoacyl−tRNA biosynthesis and glycine, serine and threonine metabolism pathways significantly correlated with the differential metabolites based on Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis (p < 0.05). Furthermore, the overall odors were significantly different among the LSCKs with different fermentation periods, as detected by E-nose. The present study describes the change trend of metabolites during LSCK fermentation and elucidates important metabolic pathways in LSCK, providing a theoretical basis for the target regulation of functional metabolites in kohlrabi and the optimization of LSCK processing.
Late Pruning and Forced Vine Regrowth in Chardonnay and Pinot Noir: Benefits and Drawbacks in the Trento DOC Basin (Italy)
Authors: Bertamini Massimo , Faralli Michele
Published: April 2023

Targeted pruning techniques may have the potential to shift phenological progression in grapevines. These approaches can be useful to escape late frost (after budburst) and to delay ripening, maintaining yield and berry quality under specific environmental scenarios and for targeted oenological aims. In this work we tested a series of pruning methods (late pruning and different forcing approaches to unlock the para-dormant buds) with the primary objective of delaying phenological onset while increasing must quality components in the Trento DOC basin (Italy) over three field seasons either in cv Chardonnay or cv Pinot noir. Delayed pruning shifted the onset of most of the phenological stages by 3 to 10 days with a general increase in must acidity at harvest over two seasons. Forcing techniques, and in particular forcing vine regrowth (i.e., removing primary productivity along with leaves and secondary shoots to force dormant bud growth), substantially reduced yield per vine (p < 0.001) but significantly (p < 0.001) enhanced total acidity and yeast available nitrogen when compared to winter pruning vines in both Chardonnay and Pinot noir. Different spring pruning for unlocking para-dormant buds aimed at double-cropping in 2022 did not yield a secondary harvest potentially due to lack of vigor in the vineyard (Pinot noir) and unfavorable environmental conditions that putatively anticipated bud pre-dormancy. However, reduced sugar levels in the primary productivity bunches of the treated vines were observed, suggesting that early source limitation (e.g., at fruit set) applied via reduced active photosynthetic leaf area may slow down technological ripening even if compensatory behaviors were observed in the treated plants through enhanced stomatal conductance. Our work provides evidence of the potential usefulness of different pruning approaches for manipulating phenological progression and berry ripening dynamics under climate change scenario in the Trento DOC area and suggests a lack of efficacy and specific drawbacks particularly in dry and hot years.
Hyperparasitic Fungi against Melon Powdery Mildew Pathogens: Quantitative Analysis of Conidia Released from Single Colonies of Podosphaera xanthii Parasitised by Ampelomyces
Authors: Kimura Yutaka , Németh Márk Z. , Numano Kana , Mitao Asami , Shirakawa Tomomi , Seress Diána , Takikawa Yoshihiro , Kakutani Koji , Matsuda Yoshinori , Kiss Levente , Nonomura Teruo
Published: April 2023

In this study, we evaluated the effectiveness of hyperparasitic fungi in controlling powdery mildew (PM). In a greenhouse, we spray-inoculated single colonies of the melon PM-causing fungus Podosphaera xanthii strain KMP-6N at three different fungal developmental stages (i.e., 5, 10, and 15 days old) with spores of the hyperparasitic fungus Ampelomyces sp. strain Xs-q. After spray inoculation, we collected and counted KMP-6N conidia produced as asexual progeny from PM colonies using an electrostatic rotational spore collector. Collector insulator films were replaced at 24 h intervals until KMP-6N ceased to release additional progeny conidia. Conidial releases from each of the single Xs-q-inoculated KMP-6N colonies gradually reduced, then stopped within ca. 4 and 8 days of the first treatment in 5- and 10-day-old KMP-6N colonies, and within ca. 20 days of the second spray treatment in 15-day-old KMP-6N colonies, respectively. The total numbers of asexual progeny conidia collected from single 5-, 10-, and 15-day-old colonies were ca. 156, 1167, and 44,866, respectively. After electrostatic spore collection, conidiophores in Xs-q-uninoculated KMP-6N colonies appeared normal, whereas almost all conidiophores in 5- and 10-day-old Xs-q-inoculated KMP-6N colonies were completely deformed or collapsed due to the infection of the hyperparasitic fungus. This is the first study to apply electrostatic and digital microscopic techniques to clarify the impact of fungal hyperparasitism on mycohost survival, and, in particular, to assess quantitatively and visually the suppression of conidial release from any PM colonies infected with Ampelomyces.
Complex Cd–Pb Multigenerational Exposure Improves the Growth and Food Utilization of the Cutworm Spodoptera litura
Authors: Zhang Meifang , Chen Jin , Wu Kaixuan , Chen Shiru , Wang Jianwu , Shu Yinghua
Published: April 2023

Concurrent exposure to cadmium (Cd) and lead (Pb) is prevalent in the environment, but information on the long-term impacts of complex Cd–Pb exposure on herbivorous insects, especially at low doses, is scant. We studied the effects of complex Cd–Pb exposure (4.06 mg/kg Cd and 12.5 mg/kg Pb) on the growth and food utilization of the herbivorous insect Spodoptera litura for 10 continuous generations. Cd or Pb ingestion, excretion and accumulation by insect at the different developmental stages was determined for ten generations. The weighted scores calculated by the analytic hierarchy process (AHP) on the basis of the parameters of survival, growth and food utilization indicated that complex Cd–Pb exposure had positive impacts on the insects, regardless of generations. Compared with Cd (4.06 mg/kg Cd) and Pb (12.5 mg/kg Pb) alone, complex Cd–Pb exposure showed antagonistic interactions. After exposure to complex Cd–Pb, although larvae significantly increased heavy metal uptake along with the elevated ECD and ECI, insects enhanced heavy metal excretion via the feces and puparium; consequently, heavy metal accumulation in the insect body significantly decreased. With increasing generations, the positive impacts of complex Cd–Pb stress on insects became increasingly obvious, and the uptake of Cd or Pb decreased while the excretion of Cd or Pb increased, which demonstrated that insect tolerance to Cd–Pb exposure at low concentrations increased over generations.
Various Population Structures of Cryphonectria parasitica in Cáceres (Spain) Determine the Feasibility of the Biological Control of Chestnut Blight with Hypovirulent Strains
Authors: Rodríguez-Molina María del Carmen , García-García María Blanca , Osuna María Dolores , Gouveia Eugénia , Serrano-Pérez Paula
Published: April 2023

Chestnut blight, caused by Cryphonectria parasitica, is a severe disease that may be biologically controlled by the use of hypovirulent strains, but the diversity of the pathogen population affects biocontrol feasibility. Villuercas–Ibores–Jara, the Jerte Valley and La Vera are the main chestnut production districts in Cáceres (central-western Spain). The purpose of this study is to determine the Vegetative Compatibility Groups (VCGs) and mating types in these districts and to identify hypovirulent isolates to be used in biological control. The VCGs were determined by the merging/barrage response; PCR tests were used for the mating type determination and CHV-1 hypovirus detection. In total, 40 sites were surveyed and 269 isolates were obtained, most of them (227) from the Villuercas–Ibores–Jara district, where EU11 was the predominant VCG (88.1%) with EU1 (6.6%) and EU12 (4.4%) being also present. In the Jerte Valley and La Vera, EU1 (61.9%), EU11 (11.9%) and EU12 (11.9%) were the predominant VCGs. Both mating types were detected (48% MAT-1; 50% MAT-2) and in general, only one mating type was found in each site. The presence of Cryphonectria hypovirus 1 (CHV-1), subtype I, was identified in only one isolate (VCG EU11) from Villuercas–Ibores–Jara. The characteristics of the C. parasitica population in this district and the occurrence of CHV-1 hypovirus support the potential of successful biological control in Villuercas–Ibores–Jara using hypovirulent strains, while in the Jerte Valley and La Vera only preventive measures are recommended.
Cranial Morphology of Lithuanian Indigenous Wattle Pigs and Their Hybrids with Wild Boar
Authors: Razmaitė Violeta , Šiukščius Artūras , Marašinskienė Šarūnė
Published: April 2023

The diversity of domestic pig breeds and their hybridization increases the variety of phenotypes expressed in hybrids. The aim of this study was to quantify the differences of cranial morphologies between local Lithuanian Indigenous Wattle pigs and theirhybrids with wild boar. A total of sixteen craniometric measurements were performed on the lateral, ventral and dorsal sides of 71 skulls of Lithuanian Indigenous Wattle pigs and their hybrids, including 1/4 wild boar (WB), 1/2 wild boar and 3/4 wild boar genotypes. The weight of the skull was affected by the genotype, live weight and sex of the animal. The size of the skull, particularly related to skull length parameters, increased consistently with the increase of the wild boar proportion in the hybrids. However, the Sus scrofa genotype did not affect the skull height. Clear discrimination was possible between the local Lithuanian breed pigs and their hybrids with different proportions of wild boar and between individual groups of hybrids. The most correct classification was determined on the basis of the overall and length parameters of the crania. This could contribute to better management and utilization of hybrids.
Effect of Two Particle Sizes of Nano Zinc Oxide on Growth Performance, Immune Function, Digestive Tract Morphology, and Intestinal Microbiota Composition in Broilers
Authors: Qu Jianyu , Zuo Xixi , Xu Qiurong , Li Mengyao , Zou Lirui , Tao Ran , Liu Xiangyan , Wang Xianglin , Wang Ji , Wen Lixin , Li Rongfang
Published: April 2023

The effects of dietary supplementation with two particle sizes of nano zinc oxide (ZnO) on growth performance, immune function, intestinal morphology, and the gut microbiome were determined in a 42-day broiler chicken feeding experiment. A total of 75 one-day-old Arbor Acres broilers were randomized and divided into three groups with five replicates of five chicks each, including the conventional ZnO group (NC), the nano-ZnO group with an average particle size of 82 nm (ZNPL), and the nano-ZnO group with an average particle size of 21 nm (ZNPS). Each group was supplemented with 40 mg/kg of ZnO or nano-ZnO. Our results revealed that birds in the ZNPS group had a higher average daily gain and a lower feed-to-gain ratio than those in the NC group. ZNPS significantly increased the thymus index and spleen index, as well as the levels of serum metallothionein (MT), superoxide dismutase (SOD), and lysozyme (LZM). The ZNPS treatments reduced interleukin (IL)-1β and tumor necrosis factor-alpha (TNF-α) levels and increased IL-2 and interferon (IFN)-γ levels compared to that in the NC group. Additionally, compared with the birds in the NC group, those in the nano-ZnO group had a higher villus height to crypt depth ratio of the duodenum, jejunum, and ileum. Bacteroides increased in the ZNPS group at the genus level. Further, unidentified_Lachnospiraceae, Blautia, Lachnoclostridium, unidentified_Erysipelotrichaceae, and Intestinimonas were significantly increased in the ZNPL group. In conclusion, nano-ZnO improved the growth performance, promoted the development of immune organs, increased nonspecific immunity, improved the villus height to crypt depth ratio of the small intestine, and enriched the abundance of beneficial bacteria. Notably, the smaller particle size (21 nm) of nano-ZnO exhibited a more potent effect.
Organic Milk Production and Dairy Farming Constraints and Prospects under the Laws of the European Union
Authors: Grodkowski Grzegorz , Gołębiewski Marcin , Slósarz Jan , Grodkowska Kinga , Kostusiak Piotr , Sakowski Tomasz , Puppel Kamila
Published: April 2023

In recent years, there has been rapid development in organic farming. When choosing organic livestock products, consumers are guided by the conviction that animals are provided with the highest welfare standards and access to pasture. The purpose of this article was to trace the principles of organic farming prevailing in the EU with regard to milk production and cattle breeding. The principles of organic production are universal and their application is not limited to certified farms. Organic certification is intended to assure the consumer of the quality and method of production. Due to additional requirements imposed by law, organic cows are usually kept in better welfare conditions compared to conventional cattle, but this is not the rule. The altered taste and texture of organic milk and its products compared to conventional products mainly depends on the presence of pasture greens in the cows’ diet. Therefore, milk from conventionally kept, pasture-grazed cows may have similar characteristics and composition. Organic farms tend to have lower milk yields compared to conventional farms due to the lower consumption of concentrate feed. In the future, it is expected that the proportion of land that is unsuitable for the production of crops for human consumption will increasingly be used for cow grazing.
Inhibition of Staphylococcus pseudintermedius Efflux Pumps by Using Staphylococcus aureus NorA Efflux Pump Inhibitors
Authors: Rampacci Elisa , Felicetti Tommaso , Cernicchi Giada , Stefanetti Valentina , Sabatini Stefano , Passamonti Fabrizio
Published: April 2023

One promising approach in treating antibiotic-resistant bacteria is to “break” resistances connected with antibacterial efflux by co-administering efflux pump inhibitors (EPIs) with antibiotics. Here, ten compounds, previously optimized to restore the susceptibility to ciprofloxacin (CIP) of norA-overexpressing Staphylococcus aureus, were evaluated for their ability to inhibit norA-mediated efflux in Staphylococcus pseudintermedius and synergize with CIP, ethidium bromide (EtBr), gentamycin (GEN), and chlorhexidine digluconate (CHX). We focused efforts on S. pseudintermedius as a pathogenic bacterium of concern within veterinary and human medicine. By combining data from checkerboard assays and EtBr efflux inhibition experiments, the hits 2-arylquinoline 1, dihydropyridine 6, and 2-phenyl-4-carboxy-quinoline 8 were considered the best EPIs for S. pseudintermedius. Overall, most of the compounds, except for 2-arylquinoline compound 2, were able to fully restore the susceptibility of S. pseudintermedius to CIP and synergize with GEN as well, while the synergistic effect with CHX was less significant and often did not show a dose-dependent effect. These are valuable data for medicinal chemistry optimization of EPIs for S. pseudintermedius and lay the foundation for further studies on successful EPIs to treat staphylococcal infections.
New N-acyl Thiourea Derivatives: Synthesis, Standardized Quantification Method and In Vitro Evaluation of Potential Biological Activities
Authors: Roman Roxana , Pintilie Lucia , Căproiu Miron Teodor , Dumitrașcu Florea , Nuță Diana Camelia , Zarafu Irina , Ioniță Petre , Chifiriuc Mariana Carmen , Chiriță Cornel , Moroșan Alina , Popa Marcela , Bleotu Coralia , Limban Carmen
Published: April 2023

New N-acyl thiourea derivatives with heterocyclic rings have been synthesized by first obtaining isothiocyanate, which further reacted with a heterocyclic amine, characterized by (FT-IR, NMR spectroscopy and FT-ICR) and tested for their in vitro antimicrobial, anti-biofilm and antioxidant activities to obtain a drug candidate in a lead-optimization process. From the tested compounds, those bearing benzothiazole (1b) and 6-methylpyridine (1d) moieties revealed anti-biofilm activity against E. coli ATCC 25922 at MBIC values of 625 µg/mL. Compound 1d exhibited the highest antioxidant capacity (~43%) in the in vitro assay using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Considering the in vitro results, the highest anti-biofilm and antioxidant activities were obtained for compound 1d. Therefore, a reversed-phase high-performance liquid chromatography (RP-HPLC) method has been optimized and validated for the quantitative determination of compound 1d. The detection and quantitation limits were 0.0174 μg/mL and 0.0521 μg/mL, respectively. The R2 correlation coefficient of the LOQ and linearity curves were greater than 0.99, over the concentration range of 0.05 μg/mL–40 μg/mL. The precision and accuracy of the analytical method were within 98–102%, confirming that the method is suitable for the quantitative determination of compound 1d in routine quality control analyses. Evaluating the results, the promising potential of the new N-acyl thiourea derivatives bearing 6-methylpyridine moiety will be further investigated for developing agents with anti-biofilm and antioxidant activities.
Compliance with Antibiotic Prophylaxis in Obstetric and Gynecological Surgeries in Two Peruvian Hospitals
Authors: Arteaga-Livias Kovy , Panduro-Correa Vicky , Maguiña Jorge L. , Osada Jorge , Rabaan Ali A. , Lijarza-Ushinahua Kiara , Barboza Joshuan J. , Gomez-Gonzales Walter , Rodriguez-Morales Alfonso J.
Published: April 2023

Introduction: Surgical site infections (SSI) can be as high in gynecology and obstetrics surgeries compared to other areas. Antimicrobial prophylaxis is an effective tool in the prevention of SSIs; however, it is often not adequately administered, so this study aimed to understand the compliance and factors associated with the use of the clinical practice guidelines for antibiotic prophylaxis in gynecological surgeries in two hospitals in the city of Huanuco, Peru. Methods: An analytical cross-sectional study of all gynecologic surgeries performed during 2019 was performed. Compliance was determined based on the antibiotic chosen, dose, administration time, redosing, and prophylaxis duration. Age, hospital of origin, presence of comorbidities, surgery performed, as well as its duration, types of surgery, and anesthesia were considered as related factors. Results: We collected 529 medical records of patients undergoing gynecological surgery with a median age of 33 years. The prophylactic antibiotic was correctly indicated in 55.5% of cases, and the dose was correct in 31.2%. Total compliance with the five variables evaluated was only 3.9%. Cefazolin was the most commonly used antibiotic. Conclusion: Low compliance with the institutional clinical practice guidelines for antibiotic prophylaxis was identified, showing that antimicrobial prophylaxis in the hospitals studied was inadequate.
Changing Trends in the Global Consumption of Treatments Used in Hospitalized Patients for COVID-19: A Time Series Multicentre Study
Authors: Aranda Judit , Loureiro-Amigo Jose , Murgadella Anna , Vàzquez Núria , Feria Lucía , Muñoz Miriam , Padulles Ariadna , Abelenda Gabriela , Garcia-Vidal Carol , Tuset Montse , Albanell Marta , Boix-Palop Lucía , Sanmartí-Martínez Núria , Gómez-Zorrilla Sílvia , Echeverria-Esnal Daniel , Rodriguez-Alarcón Alicia , Borjabad Beatriz , Coloma Ana , Carratalà Jordi , Oriol Isabel
Published: April 2023

Aim: To analyze trends in the prescription of COVID-19 treatments for hospitalized patients during the pandemic. Methods: Multicenter, ecological, time-series study of aggregate data for all adult patients with COVID-19 treated in five acute-care hospitals in Barcelona, Spain, between March 2020 and May 2021. Trends in the monthly prevalence of drugs used against COVID-19 were analyzed by the Mantel–Haenszel test. Results: The participating hospitals admitted 22,277 patients with COVID-19 during the study period, reporting an overall mortality of 10.8%. In the first months of the pandemic, lopinavir/ritonavir and hydroxychloroquine were the most frequently used antivirals, but these fell into disuse and were replaced by remdesivir in July 2020. By contrast, the trend in tocilizumab use varied, first peaking in April and May 2020, declining until January 2021, and showing a discrete upward trend thereafter. Regarding corticosteroid use, we observed a notable upward trend in the use of dexamethasone 6 mg per day from July 2020. Finally, there was a high prevalence of antibiotics use, especially azithromycin, in the first three months, but this decreased thereafter. Conclusions: Treatment for patients hospitalized with COVID-19 evolved with the changing scientific evidence during the pandemic. Initially, multiple drugs were empirically used that subsequently could not demonstrate clinical benefit. In future pandemics, stakeholders should strive to promote the early implementation of adaptive randomized clinical trials.
Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy
Authors: Argaev-Frenkel Lital , Rosenzweig Tovit
Published: April 2023

Oxidative stress is an important factor in the development of type 2 diabetes (T2D) and associated complications. Unfortunately, most clinical studies have failed to provide sufficient evidence regarding the benefits of antioxidants (AOXs) in treating this disease. Based on the known complexity of reactive oxygen species (ROS) functions in both the physiology and pathophysiology of glucose homeostasis, it is suggested that inappropriate dosing leads to the failure of AOXs in T2D treatment. To support this hypothesis, the role of oxidative stress in the pathophysiology of T2D is described, together with a summary of the evidence for the failure of AOXs in the management of diabetes. A comparison of preclinical and clinical studies indicates that suboptimal dosing of AOXs might explain the lack of benefits of AOXs. Conversely, the possibility that glycemic control might be adversely affected by excess AOXs is also considered, based on the role of ROS in insulin signaling. We suggest that AOX therapy should be given in a personalized manner according to the need, which is the presence and severity of oxidative stress. With the development of gold-standard biomarkers for oxidative stress, optimization of AOX therapy may be achieved to maximize the therapeutic potential of these agents.
Development of a New Test-Rig for Wheel–Rail Contact Experiments under Large Slip Conditions
Authors: Chen Chao , Tian Chun , Zhou Jiajun , Zhai Gengwei , Yu Hao
Published: April 2023

In order to further theoretical and experimental research on adhesion recovery, an innovative new test-rig for wheel–rail contact experiments under large slip conditions was developed. The wheel-on-ring category of test-rig was determined to preserve surface conditions on rail. A scale factor of 1/4 and a circling diameter of 2 m were adopted considering the power limit in the laboratory and wheel–rail contact similarity. The test-rig consisting of wheel assemblies, ring track, gearbox, motors and sprinkler system was specially designed for motor decoupling and precise slip control. Then, the accuracy of slip under PID control was verified by simulation and experimental validation. Thereafter, experimental observations with different speeds, axle loads and surface contaminants showed the potential of the new test-rig for exploring adhesion recovery under various surface conditions.
Identification of Usefulness for Online Reviews Based on Grounded Theory and Multilayer Perceptron Neural Network
Authors: Hou Jiani , Zhu Aimin
Published: April 2023

In the context of the continuous development of e-commerce platforms and consumer shopping patterns, online reviews of goods are increasing. At the same time, its commercial value is self-evident, and many merchants and consumers manipulate online reviews for profit purposes. Therefore, a method based on Grounded theory and Multi-Layer Perceptron (MLP) neural network is proposed to identify the usefulness of online reviews. Firstly, the Grounded theory is used to collect and analyze the product purchasing experiences of 35 consumers, and the characteristics of the usefulness of online reviews in each stage of purchase decision-making are extracted. Secondly, the MLP neural network classifier is used to identify the usefulness of online reviews. Finally, relevant comments are captured as the subject and compared with the traditional classifier algorithm to verify the effectiveness of the proposed method. The experimental results show that the feature extraction method considering consumers’ purchase decisions can improve the classification effect to a certain extent and provide some guidance and suggestions for enterprises in the practice of operating online stores.
Automatic Interpretation of Potential Field Data Based on Euler Deconvolution with Linear Background
Authors: Liu Qiang , Shu Qing , Gao Wei , Luo Yao , Li Zelin , Yang Junjun , Xu Wenqiang
Published: April 2023

Euler deconvolution is a popular technique used for analyzing potential field data because it requires little prior information. However, the reliability of Euler solutions can be impacted by interference from adjacent field sources, or background fields. In this manuscript, we present an effective Euler deconvolution algorithm that accounts for linear background fields. Our algorithm, called improved finite-difference Euler deconvolution, builds upon the finite-difference method and is less susceptible to interference from nearby sources. We use this algorithm to achieve a joint estimation of the coefficients of the source coordinates, the structure index, and the linear background trend. Compared to Euler deconvolution methods based on differential similarity transformations, which also account for linear background fields, our method is easier to understand and implement programmatically and is faster. We tested our method using both 2D and 3D synthetic data, and the results indicate that our algorithm has better computational accuracy than the finite-difference algorithm and is comparable to the Euler deconvolution algorithm based on differential similarity transformations. In addition, our method was shown to be effective when tested on real data.
Optimization on Elastoplasticity of Functionally Graded Shells of Revolution under Axisymmetric Loading
Authors: Simões Moita José , Araújo Aurélio Lima , Franco Correia Victor , Soares Cristóvão Mota , Herskovits José
Published: April 2023

Depending on the load level, structures can experience a material nonlinearity known as elastoplasticity, which has an important role in the behaviour of structures. In order to avoid the elastoplastic behaviour, it is necessary to find the optimal thickness distribution, which corresponds to the minimum mass that provides an elastic behaviour for a certain load level. The elastoplasticity analysis of functionally graded axisymmetric shells under axisymmetric mechanical loading, and the subsequent optimization, was performed by using a simple conical frustum finite element model with two nodal circles; three degrees of freedom per node, which was based on Kirchhoff’s theory allowing for shear deformation; and using a reduced numerical integration procedure that is essential for its success when applied to thin shells. The formulation accounts for the calculation of the displacements and through-thickness stress distribution, including the effective stress. In this work, the thickness was the design variable in the optimization procedure and the mass was the objective function that needed to be minimized subject to a constraint imposed on the effective stress. The optimization solutions were obtained by using a feasible arc interior point gradient-based algorithm. Some illustrative examples were performed, and the corresponding results are presented and discussed.
Detection of Targets in Road Scene Images Enhanced Using Conditional GAN-Based Dehazing Model
Authors: Chow Tsz-Yeung , Lee King-Hung , Chan Kwok-Leung
Published: April 2023

Object detection is a classic image processing problem. For instance, in autonomous driving applications, targets such as cars and pedestrians are detected in the road scene video. Many image-based object detection methods utilizing hand-crafted features have been proposed. Recently, more research has adopted a deep learning approach. Object detectors rely on useful features, such as the object’s boundary, which are extracted via analyzing the image pixels. However, the images captured, for instance, in an outdoor environment, may be degraded due to bad weather such as haze and fog. One possible remedy is to recover the image radiance through the use of a pre-processing method such as image dehazing. We propose a dehazing model for image enhancement. The framework was based on the conditional generative adversarial network (cGAN). Our proposed model was improved with two modifications. Various image dehazing datasets were employed for comparative analysis. Our proposed model outperformed other hand-crafted and deep learning-based image dehazing methods by 2dB or more in PSNR. Moreover, we utilized the dehazed images for target detection using the object detector YOLO. In the experimentations, images were degraded by two weather conditions—rain and fog. We demonstrated that the objects detected in images enhanced by our proposed dehazing model were significantly improved over those detected in the degraded images.
Control Strategy of Synchronous Reluctance Motor Using Empirical Information Brain Emotional Learning Based Intelligent Controller Considering Magnetic Saturation
Authors: Liang Jing , Dong Yan , Jing Jie
Published: April 2023

The synchronous reluctance motor (SynRM) has significant nonlinear characteristics due to the problems of magnetic saturation and cross-coupling and the poor adaptability of the general controller to parameter changes seriously affects the control performance of the motor. In order to solve the above problems, this paper proposed a control system for the SynRM with a brain emotion controller based on empirical information to solve the motor control problem of magnetic saturation. Firstly, the nonlinear mathematical model of the SynRM considering magnetic saturation is established by introducing the magnetic saturation parameter. Secondly, the sensory input function and emotional cue function based on systematic error are given and the vector control system of the SynRM considering magnetic saturation is designed. The influence of the parameters and the learning rate of the brain emotional learning based intelligent controller (EI-BELBIC) on the adjustment range of the controller parameters is studied. Then the SynRM is controlled under different working conditions and the control effect is observed. The results show that the designed vector control system of the SynRM based on EI-BELBIC has strong reliability, accurate control, rapid response, and strong anti-interference ability under magnetic saturation.
Enhancing Monocrystalline Solar Module Efficiency through Front-Surface Cooling with 96% Alcohol
Authors: Djordjevic Stefan , Pantic Lana , Krstic Marko , Radonjic Ivana , Mancic Marko , Pantic Aleksandar
Published: April 2023

Electrical energy generation in solar modules is mainly limited by the increase in their temperature, and a heat removal process plays an important role. The main goal of the experiment was to keep the temperature of the cooled module below 47 °C through a series of the five short cooling and heating cycles and to determine the changes in the solar module output power during the cooling process with 96% ethyl alcohol. The optimal duration of the cooling cycles was determined to be between 3–6 min and for the heating process, it was 4–5 min. During the heating and cooling cycles the temperature of the cooled module did not exceed 42.1 °C. At the end of five active cooling cycles the temperature difference of 22.6 °C was achieved. The biggest difference in power between the cooled and uncooled module was 4.9%. The solar module efficiency was increased by 3.2%. It was concluded that alcohol, due to its evaporative losses, is not a viable cooling agent for solar modules. Nevertheless, it can serve as a potent additive in both active and passive cooling systems to augment the output power of solar modules.
Multi-Criteria Evaluation of Spatial Aspects in the Selection of Wind Farm Locations: Integrating the GIS and PROMETHEE Methods
Authors: Josimović Boško , Srnić Danijela , Manić Božidar , Knežević Ivana
Published: April 2023

Apart from wind potential, there are many other spatial factors which impact the possible implementation of wind farm projects. The spatial advantages and limitations of these factors can be used as criteria for selecting the most suitable location for a potential wind farm. The specific method for evaluating wind farm locations in this paper is novel because of its choice of spatial criteria and its two-stage evaluation procedure. The first stage involves the elimination of unfavorable areas for locating a wind farm, based on elimination criteria, using GIS. The second stage is the selection of the most suitable wind farm location using the PROMETHEE method. This is based on the multi-criteria evaluation of locations according to different weight categories and scenarios. The results are then multiplied based on which decision-making subjects can make appropriate decisions. The results indicate that the method presented has a universal character in terms of its application. However, its specifics in terms of quantitative statements for the individual spatial criteria used in the evaluation depend on the specifics of national and international regulations, the area in question and the particular project. By integrating the spatial criteria with the relevant legislation, this method has potential for global application. It aims towards systematicity, efficiency, simplicity and reliability in decision-making. In this way, potential conflicts and risks for investors and other users of the space are prevented in the earliest development phase of a wind farm project.
Color CCD High-Temperature Measurement Method Based on Matrix Searching
Authors: Li Chao , Kong Deren , Wang Yongjuan , Gao Liming , Zhang Xiangyong , Zhang Qi
Published: April 2023

High-temperature processes can have a direct impact on the state and physicochemical properties of materials, making high-temperature measurements important in scientific research, materials processing, and equipment evaluation. A temperature measurement method of color CCD based on matrix search is reported in this paper. In this method, the traditional temperature reverse calculation process is transformed into the forward matrix search process, and the process parameters such as medium absorption gamma correction are incorporated, which saves the calculation resources and is closer to the actual temperature measurement conditions. A temperature measurement process and a temperature visualization procedure are designed for this high-temperature measurement method, the flame temperature measurement experiments are carried out, and the error results are obtained. By comparing the solution results and chrominance deviation distance between the perturbation emissivity model and the non-perturbation emissivity model, the robustness of the solution method is discussed.