Ocular changes –cataract and retinal lesion- in Spontaneously Diabetic Torii (SDT) fatty rats, an obese type 2 diabetic model
Authors:   Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan, Maekawa Tatsuya , Nakamura Sanae ,   JT Creative Service co., ltd., Takatsuki office 1-1, Murasaki-cho, Takatsuki, Osaka, 569-1125, Japan, Miyajima Katsuhiro ,   Department of Nutritional Science and Food Safety Faculty of Applied Biosciences, Tokyo University of Agriculture 1-1-1, Sakuragaoka, Setagaya-ku, Tokyo, 156-8602, Japan, Uno Kinuko ,   Department of Nutritional Science and Food Safety Faculty of Applied Biosciences, Tokyo University of Agriculture 1-1-1, Sakuragaoka, Setagaya-ku, Tokyo, 156-8602, Japan, Yamaguchi Ayane ,   Department of Nutritional Science and Food Safety Faculty of Applied Biosciences, Tokyo University of Agriculture 1-1-1, Sakuragaoka, Setagaya-ku, Tokyo, 156-8602, Japan, Mandai Kouhei ,   Department of Nutritional Science and Food Safety Faculty of Applied Biosciences, Tokyo University of Agriculture 1-1-1, Sakuragaoka, Setagaya-ku, Tokyo, 156-8602, Japan, Gotoh Takayuki ,   Clea Japan Inc. 1-2-7, Higashiyama, Meguro-ku, Tokyo 153-8533, Japan, Shinohara Masami ,   Clea Japan Inc. 1-2-7, Higashiyama, Meguro-ku, Tokyo 153-8533, Japan, Shinozaki Yuichi ,   Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan, Sasase Tomohiko ,   Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan, Fatchiyah Fatchiyah ,   Research Center for Smart Molecules of Natural Genetics Resources (SMONAGENES) Brawijaya University Jl. Veteran, Ketawanggede, Kec. Lowokwaru, Kota Malang, Jawa Timur 65145, Indonesia, Ohta Takeshi ,   Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Published: April 2021

Cataract and retinopathy remain the preventable cause of blindness worldwide, and many pharmacological strategies have been proposed for the treatment of these eye diseases. Animal models play an important role in understanding the pathophysiological features of eye disease and developing for a new therapy. In this study, we investigated the development of cataract and retinal lesion with diabetes using an obese type 2 diabetic models SDT fatty rat. Macroscopic analysis in eyes was performed from 16 to 24 weeks of age and histological analysis was performed at 24 weeks of age. As a result, the lens cloudiness was observed from 19 weeks of age and the degree of the cloudiness was more progressed until 24 weeks of age. Histopathological findings, such as degeneration of lens fiber and shortening and irregular arrangement of cone and rod in retinal tissue, were observed at 24 weeks of age. In conclusion, SDT fatty rats may be useful to understand the pathological features in diabetic cataract and retinopathy develop a new therapy for the disease.