bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of a Fluorescence Anisotropy-Based Assay to Quantify Transglutaminase 2 Activity in Cell Lysates
Authors: Hauser Sandra , Sommerfeld Paul , Wodtke Johanna , Hauser Christoph , Schlitterlau Paul , Pietzsch Jens , Löser Reik , Pietsch Markus , Wodtke Robert
Published: April 2022

Transglutaminase 2 (TGase 2) is a multifunctional protein which is involved in various physiological and pathophysiological processes. The latter also include its participation in the development and progression of malignant neoplasms, which are often accompanied by increased protein synthesis. In addition to the elucidation of the molecular functions of TGase 2 in tumor cells, knowledge of its concentration that is available for targeting by theranostic agents is a valuable information. Herein, we describe the application of a recently developed fluorescence anisotropy (FA)-based assay for the quantitative expression profiling of TGase 2 by means of transamidase-active enzyme in cell lysates. This assay is based on the incorporation of rhodamine B-isonipecotyl-cadaverine (R-I-Cad) into N,N-dimethylated casein (DMC), which results in an increase in the FA signal over time. It was shown that this reaction is not only catalyzed by TGase 2 but also by TGases 1, 3, and 6 and factor XIIIa using recombinant proteins. Therefore, control measurements in the presence of a selective irreversible TGase 2 inhibitor were mandatory to ascertain the specific contribution of TGase 2 to the overall FA rate. To validate the assay regarding the quality of quantification, spike/recovery and linearity of dilution experiments were performed. A total of 25 cancer and 5 noncancer cell lines were characterized with this assay method in terms of their activatable TGase 2 concentration (fmol/µg protein lysate) and the results were compared to protein synthesis data obtained by Western blotting. Moreover, complementary protein quantification methods using a biotinylated irreversible TGase 2 inhibitor as an activity-based probe and a commercially available ELISA were applied to selected cell lines to further validate the results obtained by the FA-based assay. Overall, the present study demonstrates that the FA-based assay using the substrate pair R-I-Cad and DMC represents a facile, homogenous and continuous method for quantifying TGase 2 activity in cell lysates.
Audio Storytelling Innovation in a Digital Age: The Case of Daily News Podcasts in Spain
Authors: Asier Leoz-Aizpuru , Luis Miguel Pedrero-Esteban
Published: April 2022

On the 1st of February 2017, The New York Times published the first episode of ‘The Daily’, a news podcast hosted by Michael Barbaro that, five years later, has become the most popular in the world with four million listeners each day and more than 3000 million accumulated downloads. The unprecedented success of this audio format, that has emerged in a traditional newspaper, has helped to revamp radio news and has spread in various versions all over the world. This investigation analyses daily podcasts in Spain and, by means of a quantitative and qualitative study, identifies their main themes, narrative structures, and expressive contributions based on four illustrative experiences in this market: ‘Quién dice qué‘, ‘AM’, ‘El Mundo al día’, and ‘Un tema al día’. The results reveal the consolidation of two clearly defined models: a more conventional one based on radio bulletins and news reports; and another, more innovative model that replicates the anglophone formula that opts for depth, dissemination, and a conversational tone to redefine the canons of the audio news narrative and take advantage of the potential of audio as a new distribution channel for newspapers in the digital eco-system.
Role of Four-Chamber Heart Ultrasound Images in Automatic Assessment of Fetal Heart: A Systematic Understanding
Authors: Gudigar Anjan , U. Raghavendra , Samanth Jyothi , Vasudeva Akhila , A. J. Ashwal A. , Nayak Krishnananda , Tan Ru-San , Ciaccio Edward J. , Ooi Chui Ping , Barua Prabal Datta , Molinari Filippo , Acharya U. Rajendra
Published: April 2022

The fetal echocardiogram is useful for monitoring and diagnosing cardiovascular diseases in the fetus in utero. Importantly, it can be used for assessing prenatal congenital heart disease, for which timely intervention can improve the unborn child’s outcomes. In this regard, artificial intelligence (AI) can be used for the automatic analysis of fetal heart ultrasound images. This study reviews nondeep and deep learning approaches for assessing the fetal heart using standard four-chamber ultrasound images. The state-of-the-art techniques in the field are described and discussed. The compendium demonstrates the capability of automatic assessment of the fetal heart using AI technology. This work can serve as a resource for research in the field.
Enhanced Photocatalytic Activity of WS2/TiO2 Nanofibers for Degradation of Phenol under Visible Light Irradiation
Authors: Nada Engy Ahmed , El-Maghrabi Heba Hassan , Raynaud Patrice , Ali Hager Rabea , Abd El-Wahab Saad , Sabry Dina Yahea , Moustafa Yasser Mohamed , Nada Amr Ahmed
Published: April 2022

Binary composite WS2/TiO2 nanofibers (WTN) were elaborated by electrospinning technique. The photocatalytic efficiency of the binary nanofibers was changed via different ratios between WS2 and TiO2. The structural, morphological and optical properties of the prepared nanofibers were evaluated by Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and UV-Vis diffuse reflectance spectroscopy (UV-vis/DRS), respectively. The prepared nanofibers showed a remarkable performance in photocatalytic efficiency of phenol compound degradation under visible light. WTN nanofibers showed superior photocatalytic activity (83%) and high stability of several cycles under visible light. Therefore, WS2/TiO2 nanofibers have great prospects for the treatment of wastewater from toxic organic contamination due to their excellent photocatalytic performance reusability and recyclability.
Size Dependent Properties of Reactive Materials
Authors: Shekhawat Deepshikha , Vauth Maximilian , Pezoldt Jörg
Published: April 2022

The nature of the self-sustained reaction of reactive materials is dependent on the physical, thermal, and mechanical properties of the reacting materials. These properties behave differently at the nano scale. Low-dimensional nanomaterials have various unusual size dependent transport properties. In this review, we summarize the theoretical and experimental reports on the size effect on melting temperature, heat capacity, reaction enthalpy, and surface energy of the materials at nano scale because nanomaterials possess a significant change in large specific surface area and surface effect than the bulk materials. According to the theoretical analysis of size dependent thermodynamic properties, such as melting temperature, cohesive energy, thermal conductivity and specific heat capacity of metallic nanoparticles and ultra-thin layers varies linearly with the reciprocal of the critical dimension. The result of this scaling relation on the material properties can affect the self-sustained reaction behavior in reactive materials. Resultant, powder compacts show lower reaction propagation velocities than bilayer system, if the particle size of the reactants and the void density is decreased an increase of the reaction propagation velocity due to an enhanced heat transfer in reactive materials can be achieved. Standard theories describing the properties of reactive material systems do not include size effects.
Cochlear Implantation Improves Both Speech Perception and Patient-Reported Outcomes: A Prospective Follow-Up Study of Treatment Benefits among Adult Cochlear Implant Recipients
Authors: Rasmussen Kasper Møller Boje , West Niels Cramer , Bille Michael , Sandvej Matilde Grønborg , Cayé-Thomasen Per
Published: April 2022

Cochlear implantation is considered the best treatment option for patients with severe-to-profound sensorineural hearing loss for whom conventional hearing aids are insufficient. We used a repeated measures longitudinal approach to evaluate speech recognition and patient-reported outcomes after cochlear implantation in an unbiased cohort of Danish adult patients in a prospective cohort study. We assessed 39 recipients before and two times after implantation using a battery of tests that included Dantale I, the Danish Hearing in Noise Test, the Nijmegen Cochlear Implant Questionnaire, and the Speech, Spatial, and Qualities of Hearing Scale. The study group improved significantly on all outcome measures following implantation. On average, Dantale I scores improved by 29 percentage points and Hearing in Noise Test scores improved by 22 percentage points. Most notably, the average Dantale score improved from 26 to 70% in the CI in quiet condition and from 12 to 42% in the cochlear implantation in noise condition when tested monaurally. Dantale demonstrated a significant positive correlation with Nijmegen Cochlear Implant Questionnaire and Speech, Spatial, and Qualities of Hearing Scale scores, while Hearing in Noise Test had no significant correlation with the patient-reported outcome measures. Patients improved significantly at 4 months and marginally improved further at 14 months, indicating that they were approaching a plateau. Our study’s use of audiometric and patient-reported outcome measures provides evidence of the treatment benefits of cochlear implantation in adults, which may help physicians advise patients on treatment decisions and align treatment benefit expectations, as well as serve as a foundation for the development of new cochlear implantation selection criteria.
Evaluation of the Efficacy and Effects of Common Hepatic Artery Reconstruction in Pancreas Transplantation: A Randomized Controlled Trial
Authors: Aida Naohiro , Ito Taihei , Kurihara Kei , Hiratsuka Izumi , Shibata Megumi , Suzuki Atsushi , Kenmochi Takashi
Published: April 2022

Maintenance of postoperative graft flow is important in pancreas transplantation. In Japan, reconstruction of the common hepatic artery is performed primarily to increase perfusion in the pancreatic head. We investigated the effects of common hepatic artery reconstruction on patient and graft survival and endocrine functions. Twenty-nine cases of pancreas transplantation were registered in the clinical trial. Of the 29 cases, four were excluded because of the risk of ischemia without reconstruction or complicated reconstruction due to a narrow artery. A total of 25 cases were randomized into two groups: 13 in the non-reconstructed group and 12 in the reconstructed group. The 1-year patient survival and graft survival rates of the non-reconstructed and reconstructed groups were 92.3% and 83.3%, and 91.7% and 82.5%, respectively. The incidence of complications in the two groups was comparable, with 38.5% (5/13 cases) in the non-reconstructed group and 33.3% (4/12 cases) in the reconstructed group. The results of the glucagon stimulation test and oral glucose tolerance test at 1 month and 1 year post-transplantation were comparable. Common hepatic artery reconstruction is not essential unless there is risk of ischemia. This study was registered at the University Hospital Medical Information Network Clinical Trials Registry under UMIN000027213.
Impact of the Aortic Geometry on TAVI Prosthesis Positioning Using Self-Expanding Valves
Authors: Breitbart Philipp , Czerny Martin , Minners Jan , Schröfel Holger , Neumann Franz-Josef , Ruile Philipp
Published: April 2022

Background: The impact of transcatheter heart valve (THV) position on the occurrence of paravalvular leakage and permanent pacemaker implantation caused by new-onset conduction disturbances is well described. The purpose of this study was to investigate the influence of the geometry of the thoracic aorta on the implantation depth after TAVI (transcatheter heart valve implantation) using self-expanding valve (SEV) types. Methods: We evaluated three-dimensional geometry of the thoracic aorta based on computed tomography angiography (CTA) in 104 subsequently patients receiving TAVI with SEV devices (Evolut R). Prosthesis position was determined using the fusion imaging method of pre- and post-procedural CTA. An implantation depth of ≥4 mm was defined as the cut-off value for low prosthesis position. Results: The mean implantation depth of the THV in the whole cohort was 4.3 ± 3.0 mm below annulus plane. THV position was low in 66 (63.5%) patients and high in 38 (36.5%) patients. After multivariate adjustment none of the aortic geometry characteristics showed an independent influence on the prosthesis position—neither the Sinus of Valsalva area (p = 0.335) nor the proximal aortic arch diameter (p = 0.754) or the distance from annulus to descending aorta (p = 0.309). Conclusion: The geometry of the thoracic aorta showed no influence on the positioning of self-expanding TAVI valve types.
Clinical Applications of Artificial Intelligence—An Updated Overview
Authors: Busnatu Ștefan , Niculescu Adelina-Gabriela , Bolocan Alexandra , Petrescu George E. D. , Păduraru Dan Nicolae , Năstasă Iulian , Lupușoru Mircea , Geantă Marius , Andronic Octavian , Grumezescu Alexandru Mihai , Martins Henrique
Published: April 2022

Artificial intelligence has the potential to revolutionize modern society in all its aspects. Encouraged by the variety and vast amount of data that can be gathered from patients (e.g., medical images, text, and electronic health records), researchers have recently increased their interest in developing AI solutions for clinical care. Moreover, a diverse repertoire of methods can be chosen towards creating performant models for use in medical applications, ranging from disease prediction, diagnosis, and prognosis to opting for the most appropriate treatment for an individual patient. In this respect, the present paper aims to review the advancements reported at the convergence of AI and clinical care. Thus, this work presents AI clinical applications in a comprehensive manner, discussing the recent literature studies classified according to medical specialties. In addition, the challenges and limitations hindering AI integration in the clinical setting are further pointed out.
Combined Stimulation of the Substantia Nigra and the Subthalamic Nucleus for the Treatment of Refractory Gait Disturbances in Parkinson’s Disease: A Preliminary Study
Authors: Villadóniga Marta , Cabañes-Martínez Lidia , López-Viñas Laura , Fanjul Samira , del Álamo Marta , Regidor Ignacio
Published: April 2022

Deep brain stimulation of the subthalamic nucleus is efficient for the treatment of motor symptoms (i.e., tremors) in patients with Parkinson’s disease. Gait disorders usually appear during advanced stages of idiopathic Parkinson’s disease in up to 80% of patients and have an important impact on their quality of life. The effects of deep brain stimulation of the subthalamic nucleus on gait and balance are still controversial. For this reason, alternative targets have been considered, such as stimulation of the pedunculopontine nucleus and the pars reticulata of substantia nigra, involved in the integration of the functional connections for gait. Due to the proximity of the subthalamic nucleus to the substantia nigra, their combined stimulation is feasible and may lead to better outcomes, improving axial symptoms. Our objective was to prospectively compare simultaneous stimulation of both structures versus conventional subthalamic stimulation in improving gait disorders. In ten patients with advanced Parkinson’s disease, deep brain stimulation leads (eight linear contacts) were implanted, and gait analysis was performed 6 months after surgery in off-stimulation and after 4 weeks of dual or single subthalamic stimulation. An improvement in gait parameters was confirmed with both stimulation conditions, with better results with combined substantia nigra and subthalamic stimulation compared with conventional subthalamic stimulation. Further studies are needed to determine if this effect remains after long-term dual-target stimulation.
Pathways Linking the Big Five to Psychological Distress: Exploring the Mediating Roles of Stress Mindset and Coping Flexibility
Authors: Chen Luxi , Qu Li , Hong Ryan Y.
Published: April 2022

Personality affects the vulnerability to the emotional symptoms of depression and anxiety. This study investigated whether stress mindset (general belief about the nature of stress) and coping flexibility (the ability to terminate ineffective coping strategies and adopt alternative ones) mediate the relations of the Big Five personality traits to psychological distress. A total of 260 undergraduate students (60.4% female) in Singapore completed self-reported questionnaires. A series of path analyses was performed. Firstly, a dual-pathway model of stress coping was established, which consisted of (a) a stress–threat–distress pathway where a stress-is-a-threat mindset mediated the association between stressful experiences and psychological distress and (b) a challenge–flexibility–enhancement pathway where coping flexibility mediated the relation of a stress-is-a-challenge mindset to a lower level of psychological distress, without being influenced by stressful experiences. Furthermore, Neuroticism was associated with the stress–threat–distress pathway, with stressful experiences and a stress-is-a-treat mindset mediating the relation of Neuroticism to psychological distress. Conscientiousness was associated with the challenge–flexibility–enhancement pathway, with a stress-is-a-challenge mindset and coping flexibility mediating the relation of Conscientiousness to less psychological distress. Extraversion, Agreeableness, and Openness were directly associated with greater coping flexibility. The findings enrich the literature on personality and stress coping and inform future interventions to promote mental health.
Multi-Scale Influence of Flexible Submerged Aquatic Vegetation (SAV) on Estuarine Hydrodynamics
Authors: Holzenthal Elizabeth R. , Hill David F. , Wengrove Meagan E.
Published: April 2022

Bottom friction is an important process in coastal and estuarine environments because it can reduce wave heights and moderate tidal currents. When modeling large systems with spatially varying hydraulic properties, bottom friction values are commonly derived from land use classification products. However, estimation of bottom friction for vegetated areas can be more challenging due to the complicated and time-varying geometry of the roughness elements. This is particularly true of flexible, buoyant submerged aquatic vegetation (SAV) species, such as seagrasses and kelps, that deform under waves and currents. In this study we incorporate a dynamic friction model that includes the temporal variation in SAV drag forces into a depth-integrated coupled circulation-wave model. In vegetated areas, the bottom friction is continuously updated based on plant geometry, water depth, and combined wave-current velocities. Taking a multi-scale approach, we use the model to investigate the impact of SAV dynamics on both the localized and the integrated bay-wide hydrodynamics of a riverine and tidally influenced estuary. First, we investigate SAV modification of velocity fields and its implications for sediment transport and circulation pathways. Then, we show how SAV can modify tidal behavior throughout the estuary.
Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis
Authors: Förster-Ruhrmann Ulrike , Szczepek Agnieszka J. , Pierchalla Greta , Fluhr Joachim W. , Artuc Metin , Zuberbier Torsten , Bachert Claus , Olze Heidi
Published: April 2022

Chronic rhinosinusitis (CRS) with (CRSwNP) or without nasal polyps (CRSsNP) is a persistent, heterogeneous inflammatory condition affecting the upper respiratory tract. The present study aimed to improve the characterization of CRS endotypes based on the chemokine and cytokine expression pattern in the CRS tissues. Concentrations of chemokines and cytokines were measured in tissues from nasal biopsies obtained from 66 CRS patients and 25 control subjects using multiplexing or single analyte technologies. Cluster analysis based on the concentration of type-1 (MCP-3/CCL7, MIP-1 α/CCL3), type-2 (IL-5, MCP-3/CCL7, MIP-1 α/CCL3, TARC/CCL17, PARC/CCL18, IP-10/CXCL10, ECP), and type-3 (IL-22) chemokines and cytokines identified six CRS endotypes (clusters). Cluster 1 (type-3) and 2 (type-1) were associated with a low prevalence of nasal polyps, Cluster 3 (type-1, -2, -3) and Cluster 4 (type-2, -3, medium IL-22) with medium, and Cluster 5 (type-2, -3, high Il-22) and Cluster 6 (type-2) with high prevalence of nasal polyps. Asthma was highly prevalent in Cluster-6. Our findings add to the existing knowledge of CRS endotypes and may be useful for the clinical decision-making process. The advancement of biologics therapy for upper respiratory tract disorders rationalizes the personalized diagnostic approach to warrant a successful treatment and monitoring of CRS.
Epilepsy and Diagnostic Dilemmas: The Role of Language and Speech-Related Seizures
Authors: Papadopoulou Soultana , Pavlidou Efterpi , Argyris Georgios , Flouda Thaleia , Koukoutsidi Panagiota , Krikonis Konstantinos , Shah Sidrah , Chirosca-Vasileiou Dana , Boussios Stergios
Published: April 2022

Although the impact of epilepsy on expressive language is heavily discussed, researched, and scientifically grounded, a limited volume of research points in the opposite direction. What about the causal relationship between disorder-related language activities and epileptic seizures? What are the possible diagnostic dilemmas that experts in the field of speech-language pathology, neurology, and related fields face? How far has research gone in investigating psychogenic nonepileptic seizures, the misdiagnosis of which can be a thorny issue for clinicians and a detrimental factor for the patients’ health? In order to address these questions, the study at hand focuses on a common, ever-intensified (by the COVID-19 pandemic) speech disorder—stuttering, and explores the pathophysiological and psychogenic background of the phenomenon. It also looks at the role of stuttering as a contributing factor to the appearance of epileptic seizures, in the hope of drawing attention to the complexity and importance of precise detection of stuttering-induced epilepsy, as a specific subcategory of language-induced epilepsy.
Effectiveness of Multicomponent Home-Based Rehabilitation in Elderly Patients after Hip Fracture Surgery: A Randomized Controlled Trial
Authors: Lee Haneul , Lee Seon-Heui
Published: April 2022

This randomized controlled study aimed to assess the clinical effectiveness of an 8-week personalized multicomponent home-based rehabilitation (MHR) program by comparing it with a home exercise program after discharge. Forty patients (≥60 years old) who underwent hip surgery were randomly assigned to multicomponent home-based rehabilitation (MHR) and home exercise groups. The MHR program included strength, endurance, balance, and breathing exercises; modifications to the home environment; education on assistive device use; pressure ulcer care; nutrition management; and motivational counseling. The MHR group received 24 visits from rehabilitation staff for 8 weeks (3 times a week), while the home exercise group received home exercises focusing on strengthening described in the leaflet. The rehabilitation staff prescribed the intensity of exercise at the first visit, and the home exercise group exercised without supervision after that for 8 weeks. Both groups received a 10-min phone call once a week for overall counseling to ensure high adherence to home exercises. Among the 40 participants, 29 (72.5%) completed the trial. The primary outcomes were balance and mobility. Balance was assessed using the functional reach test (FRT), and the timed up-and-go test (TUG) was used to assess balance and mobility. Data were analyzed using the intention-to-treat principle. The MHR group showed significant improvement compared to the home exercise group for FRT (mean difference (MD) 4.4 cm; 95% confidence interval (CI) 1.0 to 7.8) and TUG (MD: −4.2 s; 95% CI −8.0 to −0.3) after 8 weeks of intervention. Subjective pain and physical components of general health-related quality of life also improved significantly in the MHR group. No serious adverse events related to the interventions were observed. The eight-week of MHR program can effectively improve balance and mobility.
Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections
Authors: Di Giambenedetto Simona , Borghetti Alberto , Quagliozzi Lorena , Gallucci Valeria , Lombardi Francesca , Ciccullo Arturo , Fagotti Anna , Tamburrini Enrica , Scambia Giovanni
Published: April 2022

Healthcare-associated infections (HCAIs) represent a major cause of morbidity and mortality in gynecologic cancer patients, requiring personalized cures. A retrospective study on gynecologic patients with HCAIs, managed through an antimicrobial stewardship program, was performed, focusing on rates of clinical cure, breakthrough/relapse of infections, death, and time of hospital stay (THS). In total, 27 patients (median 60 years, mainly suffering from ovarian, cervical, and uterine cancer) were evaluated by a specialist in infectious diseases and were mainly diagnosed with complicated urinary tract (cUTIs, 12 cases, 44.4%) and bloodstream infections (BSIs, 9 cases, 33.3%). A total of 15 cases (11 cUTIs, 73.3%) were managed with no need for hospitalization and received a median of 11 days of outpatient parenteral antimicrobial therapy (OPAT). In the remaining 12 cases (BSIs in 8 cases, 66.7%), the median THS was 11 days, with 15 days median overall duration of antimicrobial therapy (median 5-day reduction in THS). The management of patients also included source control and wound care. All patients reached clinical cure, with no case of breakthrough infection, one case of relapse, and one death within 30 days (not attributable to the infection). HCAIs in patients with gynecologic tumors can be managed through a patient-centered, multidisciplinary antimicrobial stewardship program.
Association between Early Phase Serum Lactate Levels and Occurrence of Delayed Neuropsychiatric Sequelae in Adult Patients with Acute Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis
Authors: Lee Heekyung , Oh Jaehoon , Kang Hyunggoo , Ahn Chiwon , Namgung Myeong , Kim Chan Woong , Kim Wonhee , Kim Young Seo , Shin Hyungoo , Lim Tae Ho
Published: April 2022

The primary goal of treating carbon monoxide (CO) poisoning is preventing or minimizing the development of delayed neuropsychiatric sequelae (DNS). Therefore, screening patients with a high probability for the occurrence of DNS at the earliest is essential. However, prognostic tools for predicting DNS are insufficient, and the usefulness of the lactate level as a predictor is unclear. This systematic review and meta-analysis investigated the association between early phase serum lactate levels and the occurrence of DNS in adult patients with acute CO poisoning. Observational studies that included adult patients with CO poisoning and reported initial lactate concentrations were retrieved from the Embase, MEDLINE, Google Scholar and six domestic databases (KoreaMED, KMBASE, KISS, NDSL, KISTi and RISS) in January 2022. Lactate values were collected as continuous variables and analyzed using standardized mean differences (SMD) using a random-effect model. The risk of bias was evaluated using the Quality in Prognosis Studies (QUIPS) tool, and subgroup, sensitivity and meta regression analyses were performed. Eight studies involving a total of 1350 patients were included. The early phase serum lactate concentration was significantly higher in the DNS group than in the non-DNS group in adult patients with acute CO poisoning (8 studies; SMD, 0.31; 95% CI, 0.11–0.50; I2 = 44%; p = 0.002). The heterogeneity decreased to I2 = 8% in sensitivity analysis (omitting Han2021; 7 studies; SMD, 0.38; 95% CI, 0.23–0.53; I2 = 8%; p < 0.001). The risk of bias was assessed as high in five studies. The DNS group was associated with significantly higher lactate concentration than that in the non-DNS group.
Radiotherapy of Breast Cancer in Laterally Tilted Prone vs. Supine Position: What about the Internal Mammary Chain?
Authors: Temme Nils , Hermann Robert , Hinsche Tanja , Becker Jan-Niklas , Sonnhoff Mathias , Kaltenborn Alexander , Carl Ulrich , Christiansen Hans , Geworski Lilli , Nitsche Mirko
Published: April 2022

Background: In the multimodal breast-conserving curative therapy of some high-risk breast cancer patients, extended external beam radiotherapy (EBRT) not only to the breast but also to the supraclavicular fossa and the internal mammary chain (parasternal region (PSR)) is indicated. We report a dosimetric study on the EBRT of the breast (“B”) and the breast including PSR (“B + PSR”), comparing the supine and the laterally tilted prone patient positions in free breathing. Methods: The planning CT scans of 20 left- and 20 right-sided patients were analyzed. EBRT plans were calculated with 3D conformal EBRT (3D) and with intensity-modulated EBRT (IMRT) for “B” and “B + PSR” in the prone and supine positions. The mean and threshold doses were computed. The quality of EBRT plans was compared with an overall plan assessment factor (OPAF), comprising three subfactors, homogeneity, conformity, and radiogenic exposure of OAR. Results: In the EBRT of “B”, prone positioning significantly reduced the exposure of the OARs “heart” and “ipsilateral lung” and “lymphatic regions”. The OPAF was significantly better in the prone position, regardless of the planning technique or the treated breast side. In the EBRT of “B + PSR”, supine positioning significantly reduced the OAR “heart” exposure but increased the dose to the OARs “ipsilateral lung” and “lymphatic regions”. There were no significant differences for the OPAF, independent of the irradiated breast side. Only the IMRT planning technique increased the chance of a comparatively good EBRT plan. Conclusion: Free breathing prone positioning significantly improves plan quality in the EBRT of the breast but not in the EBRT of the breast + PSR.
To Trust or Not to Trust? COVID-19 Facemasks in China–Europe Relations: Lessons from France and the United Kingdom
Authors: Tran Emilie , Tseng Yu-chin
Published: April 2022

At the crossroads of sociology and international relations, this interdisciplinary and comparative research article explores how the COVID-19 outbreak has impacted China–Europe relations. Unfolding the critical moments of the COVID-19 outbreak, this article characterizes the evolution of China–Europe relations with regard to the facemask. This simple object of self-protection against the coronavirus strikingly became a source of contention between peoples and states. In the face of this situation, we argue that the facemask is the prism through which to illustrate (1) the transnational links between China and its overseas population, (2) the changing social perceptions of China and Chinese-looking people in European societies, and (3) the advent of China’s health diplomacy and its reception in Europe. Comparing two European settings—France and the United Kingdom (UK)—the common denominator appears to be the reduced trust, if not outright distrust, between individuals and communities in the French and British contexts, and in Sino–French and Sino–British relations at the transnational level. Combining critical juncture theory and (dis)trust in international relations as our analytical framework, this article examines how the facemask became a politicized object, both between states and between Mainland China and its overseas population, as the epidemic unfolded throughout Europe. Adopting a qualitative approach, our dataset comprises the analysis of official speeches and statements; press releases; traditional and social media content (especially through hashtags such as #JeNeSuisPasUnVirus, #IAmNotAVirus, #CoronaRacism, etc.); and interviews with Chinese, French, and British community members.
The Multifunctionality and Territoriality of Peri-Urban Agri-Food Systems: The Metropolitan Region of Madrid, Spain
Authors: López-Estébanez Nieves , Yacamán-Ochoa Carolina , Mata-Olmo Rafael
Published: April 2022

This paper addresses the Multifunctional and Territorialised Agri-Food Systems (MTLAFS) in areas of direct urban influence, focusing on the metropolitan region of Madrid. MTLAFS are contextualised as alternatives to the hegemonic global model of mass production and consumption. They are created by combining two conceptual and theoretical bodies of knowledge that share many elements: the study of Local Agri-Food Systems (LAFS), a critical approach to agri-food economies and the re-territorialisation of agri-food systems. The paper analyses the factors that negatively affect the resilience of LAFS and it describes re-territorialisation strategies that enable MTLAFS to be built. By using a multi-criteria methodology to identify agri-environmental and food governance indicators, the research identifies and describes the characteristics that allow the case studies selected in the region of Madrid to be classified as MTLAFS. This has been carried out by gathering the main discussion points on the fractures and relocation strategies that accentuate the vulnerability or, on the contrary, enhance the resilience of the cases analysed. The paper concludes with some recommendations for strengthening the socio-ecological resilience of MTLAFS by using the systemic basis provided by the agro-urban project. This agro-urban project brings together different public policies, governance tools, territorial and food planning, as well as agrarian practices anchored to each specific territory. All these agrarian practices contribute to the configuration of an alternative territorial agri-food model that ensures food security and a shift towards the sustainable development of our planet.
Accuracy Assessment of the Building Height Copernicus Data Layer: A Case Study of Bratislava, Slovakia
Authors: Szatmári Daniel , Kopecká Monika , Feranec Ján
Published: April 2022

High buildings have generally changed the morphology of cities in recent decades, and they have a significant impact on multiple processes in the urban area. Building height is one of the criteria for urban land cover classification in local climate zone delineation and urban heat island modeling. The European Union’s Earth observation program Copernicus aims to achieve a global, continuous, autonomous, high-quality, wide-range Earth observation capacity. One of the most recent Urban Atlas layers is the Building Height 2012 (BH2012) layer released in 2018, which consists of a 10 m resolution raster layer containing height information generated for core urban areas of the capitals of the EEA38 countries and the United Kingdom. This contribution aims to present the accuracy validation of the BH2012 data in Bratislava using the Slovak Basic Database for the Geographic Information System (ZBGIS). To compare the two datasets, four different tests were performed for the following group of landmark buildings: (i) with area > 100 m2, (ii) in Urban Atlas classes with soil sealing > 10%, (iii) with height > 50 m, (iv) with area > 1 ha. The results demonstrate the effect of the building’s area and compactness on the vertical accuracy of the BH2012 Copernicus data. The greater the building’s area and compactness, the smaller the difference between its height value in BH2012 and ZBGIS. The Urban Atlas class 11100 Continuous Urban Fabric (soil sealing: >80%) recorded the lowest vertical accuracy. The BH2012 database provides sufficiently accurate data for primary planning analyses of public administration bodies and various stakeholders who need to obtain information on the nature of a locality for development activities and small-scale environmental analyses. However, for detailed studies focusing on the quality of life in cities at the local level, more precise identification of the building height is recommended.
The Poverty of Farmers in a Main Grain-Producing Area in Northeast China
Authors: Ma Li , Wang Shijun , Wästfelt Anders
Published: April 2022

Farmers’ poverty has long been of global concern, mainly in poor rather than affluent areas. The goal of this paper is to better understand the range of poverty in the context of regional differentiation and to enrich knowledge on farmers’ poverty in affluent areas and areas with good natural conditions. A questionnaire survey of poor farmers in the major grain-producing area of Changchun, Northeast China was conducted. Farmers’ poverty was studied from income poverty and multidimensional poverty by intertwining qualitative and quantitative methods. The results indicate that low education levels and poor physical health were most prevalent in poor farmers, followed by income poverty and low living standards. Governmental policies and the macroeconomic situation in the agricultural sector, non-agricultural employment, aging, cultivated land, and family size correlated closely with farmers’ poverty. The macro changes in policies and global trade liberalization in the agricultural sector impacted farmers’ income through the prices of agricultural products and subsidies and influenced the effect of cultivated land. For poor farmers, the effect of employment opportunities in villages was more significant than in urban areas. Aging remains a challenge for farmers’ poverty now and in the future.
Is Early Bilingual Experience Associated with Greater Fluid Intelligence in Adults?
Authors: D’Souza Dean , Dakhch Yousra
Published: April 2022

Emerging evidence suggests that early bilingual experience constrains the development of attentional processes in infants, and that some of these early bilingual adaptations could last into adulthood. However, it is not known whether the early adaptations in the attentional domain alter more general cognitive abilities. If they do, then we would expect that bilingual adults who learned their second language early in life would score more highly across cognitive tasks than bilingual adults who learned their second language later in life. To test this hypothesis, 170 adult participants were administered a well-established (non-verbal) measure of fluid intelligence: Raven’s Advanced Progressive Matrices (RAPM). Fluid intelligence (the ability to solve novel reasoning problems, independent of acquired knowledge) is highly correlated with numerous cognitive abilities across development. Performance on the RAPM was greater in bilinguals than monolinguals, and greater in ‘early bilinguals’ (adults who learned their second language between 0–6 years) than ‘late bilinguals’ (adults who learned their second language after age 6 years). The groups did not significantly differ on a proxy of socioeconomic status. These results suggest that the difference in fluid intelligence between bilinguals and monolinguals is not a consequence of bilingualism per se, but of early adaptive processes. However, the finding may depend on how bilingualism is operationalized, and thus needs to be replicated with a larger sample and more detailed measures.
Pharmacological Strategies and Recent Advancement in Nano-Drug Delivery for Targeting Asthma
Authors: Ahmad Aftab
Published: April 2022

With a high prevalence globally, asthma is a severe hazard to human health, as well as an economic and social burden. There are now novel therapies available for asthma with the use of nanotechnology. Recent developments in nanoscience and medicine have encouraged the creation of inhalable nanomedicines that can enhance the efficacy, patient compliance, and life quality for sufferers of asthma. Nanocarriers for asthma therapy, including liposomes, micelles, polymers, dendrimers, and inorganics, are presented in depth in this study as well as the current research status of these nanocarriers. Aerosolized nanomaterial-based drug transport systems are currently being developed, and some examples of these systems, as well as prospective future paths, are discussed. New research subjects include nano-modification of medicines and the development of innovative nano-drugs. Clinical experiments have proven that nanocarriers are both safe and effective. Before nanotherapy can be applied in clinical practice, several obstacles must be addressed. We look at some of the most recent research discoveries in the subject of nanotechnology and asthma therapy in this article.
Changes in the Mean of Medical Visits Due to Psychiatric Disease in Korean Children and Adolescents before and during the COVID-19 Pandemic
Authors: Kim So Young , Lee Na-Eun , Yoo Dae Myoung , Kim Ji Hee , Kwon Mi Jung , Kim Joo-Hee , Bang Woo Jin , Choi Hyo Geun
Published: April 2022

The COVID-19 pandemic has been suggested to have adverse impacts on psychiatric disorders. This study aimed to investigate the changes in medical visits due to a wide range of psychiatric disorders in children during the COVID-19 pandemic. The medical visits of all Korean children and adolescents (0–19 years old) due to the 12 following psychiatric disorders were investigated: autism; attention-deficit/hyperactivity disorder (ADHD); depressive disorder; bipolar disorder; primary insomnia; schizophrenia; panic disorder; hypochondriasis; posttraumatic stress disorder (PTSD); anxiety disorder; anorexia nervosa; and adephagia. The mean medical visits before and during the COVID-19 pandemic were compared. The mean number of clinical visits due to autism, ADHD, depressive disorder, bipolar disorder, panic disorder, hypochondriasis, PTSD, anxiety disorder, and anorexia nervosa was higher during the COVID-19 pandemic than before the COVID-19 pandemic (all p < 0.05). The higher mean number of medical visits due to psychiatric disorders was maintained in age and sex subgroups. The female and adolescent groups demonstrated a higher mean number of medical visits due to psychiatric disorders during the COVID-19 pandemic. The medical visits due to many psychiatric disorders were higher during the COVID-19 pandemic than before COVID-19 in children and adolescents in Korea. Women and adolescents were more susceptible to psychiatric disorders during the COVID-19 pandemic.
Degenerative Meniscus in Knee Osteoarthritis: From Pathology to Treatment
Authors: Ozeki Nobutake , Koga Hideyuki , Sekiya Ichiro
Published: April 2022

Knee osteoarthritis is a common degenerative joint disease characterized by chronic knee pain and disability in daily living. The lesion can involve the cartilage as well as the synovium, bone, ligaments, and meniscus, indicating a complicated pathology for knee osteoarthritis. The association with the meniscus has recently attracted much attention. Meniscal tears can initiate and progress knee osteoarthritis, with deleterious effects on the important roles of the meniscus in load distribution, shock absorption, and stability of the knee joint. Degenerative meniscus lesions are commonly observed in elderly people, but they have less impact on the prognosis of osteoarthritis. However, they are often accompanied by meniscal extrusion, which substantially decreases the hoop function of the meniscus and increases the risk of knee osteoarthritis. When surgical treatment is necessary, meniscal tears should be repaired to the greatest extent possible to preserve meniscus function. Long-term studies show better clinical outcomes and less degenerative osteoarthritis changes following meniscal repair than following partial meniscectomy. For meniscal extrusion repair, centralization techniques have been proposed that involve suturing the meniscus-capsule complex to the edge of the tibial plateau. Advancements in orthobiologics, such as platelet-rich plasma or stem cell therapy, have the potential to prevent the initiation or progression of osteoarthritis.
High Humidity Response of Sol–Gel-Synthesized BiFeO3 Ferroelectric Film
Authors: Zhang Yaming , Li Bingbing , Jia Yanmin
Published: April 2022

In this work, a BiFeO3 film is prepared via a facile sol–gel method, and the effects of the relative humidity (RH) on the BiFeO3 film in terms of capacitance, impedance and current–voltage (I–V) are explored. The capacitance of the BiFeO3 film increased from 25 to 1410 pF with the increase of RH from 30% to 90%. In particular, the impedance varied by more than two orders of magnitude as RH varied between 30% and 90% at 10 Hz, indicating a good hysteresis and response time. The mechanism underlying humidity sensitivity was analyzed by complex impedance spectroscopy. The adsorption of water molecules played key roles at low and high humidity, extending the potential application of ferroelectric BiFeO3 films in humidity-sensitive devices.
Editorial Special Issue: “Advance Polymeric Materials: Synthesis, Properties and Applications”
Authors: Zubitur Manuela
Published: April 2022

As a consequence of their properties of lightness, strength, versatility, low toxicity, low cost and durability, the 20th century saw the beginning of the use of polymers as disruptive materials [...]
Material Selection Process for Acoustic and Vibration Applications Using the Example of a Plate Resonator
Authors: Neubauer Moritz , Schwaericke Felix , Radmann Vincent , Sarradj Ennes , Modler Niels , Dannemann Martin
Published: April 2022

In this work, a new method for selecting suitable materials is presented. This method has a high potential for a variety of engineering applications, such as the design of sound-absorbing and vibration-loaded structures, where a large number of different requirements have to be met. The method is based on the derivation of functional dependencies of selected material parameters. These dependencies can be used in parameter studies to consider parameter combinations that lie in the range of real existing and targeted material groups. This allows the parameter space to be reduced, the calculation to be accelerated, and suitable materials to be (pre-)selected for the respective application, which contributes to a more target-oriented design. The method is applied to the example of a plate resonator. For this purpose, a semi-analytical model is implemented to calculate the transmission loss as well as the reflected and dissipated sound power of plate silencers, taking into account the influence of flow velocity and fluid temperature on the performance of plate silencers.
Study on Deterioration Law and Mechanism of Gray Brick Due to Salt Crystallization
Authors: Yue Jianwei , Li Yuan , Luo Zhenxian , Huang Xuanjia , Kong Qingmei , Wang Zifa
Published: April 2022

Salinization has an important impact on the degradation of ancient masonry buildings, and systematically mastering the law of salt migration and degradation of ancient masonry buildings is an important part of the protection of ancient buildings. In this paper, the damage law of gray bricks under the action of salt crystallization is studied. The orthogonal test method is used to carry out cyclic degradation tests on gray bricks. The nominal strength is proposed as a mechanical parameter to measure the structural damage of grey bricks, and the change in compressive strength and crystallization pressure of the samples after the test is measured and analyzed. The results show that the damage of different salts in the gray bricks shows a certain difference. Magnesium sulfate and sodium chloride cause significant damage to the surface of the gray bricks, while calcium chloride does not cause significant damage to the surface of the gray bricks. When the concentrations of sodium chloride solution, calcium chloride solution and magnesium sulfate solution are less than 13.73 mol/L, 11.47 mol/L and 17 mol/L, respectively, the nominal strength of gray brick samples increases; In the range of 9.9 mol/L and 4.73–8.94 mol/L, the crystallization pressure began to appear inside the sample. The research results provide an important scientific basis for evaluating the damage caused by salting to the damage of porous ancient building materials such as masonry.