bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Cold Periods on the Biological Cycle of Marchalina hellenica
Authors: Dafnis Spiros , Gounari Sofia , Zotos Chris , Papadopoulos George
Published: April 2022

Climate change is considered a major factor affecting honeybees’ behavior and productivity with major consequences in both honey and agricultural production. Many research studies have expressed serious concerns about the mass losses of bee colonies and the role of bees as pollinators, while others have underlined important issues for the impact of the increase in temperature on honeybee abundance and honey yields. In the present work, we draw our attention to Marchalina hellenica, which is the most important honeydew-producing insect in Greece. A statistically significant forecasting model for the effect of cold periods in February on the life cycle of the insect is constructed, with the aid of the Cumulative Logit Model and the theory of runs. The forecasting model may help beekeepers plan the timely exploitation of honeydew secretions of pine trees, which will be beneficial for beekeepers, the rural economy, and forest protection. The new suggested model also indicates that, in view of the climate change scenarios seen in the literature, the life cycle of M. hellenica is expected to be drastically shorter.
Progress and Recent Advances in Solid Organ Transplantation
Authors: Thongprayoon Charat , Kaewput Wisit , Pattharanitima Pattharawin , Cheungpasitporn Wisit
Published: April 2022

Over the past decade, the number of organ transplants performed worldwide has significantly increased for patients with advanced organ failure [...]
Utilization and Regional Differences of In-Patient Services for Peripheral Arterial Disease and Acute Limb Ischemia in Germany: Secondary Analysis of Nationwide DRG Data
Authors: Trenner Matthias , Knappich Christoph , Bohmann Bianca , Heuberger Simon , Eckstein Hans-Henning , Kuehnl Andreas
Published: April 2022

Background: Peripheral arterial disease (PAD) and acute limb ischemia (ALI) pose an increasing strain on health care systems. The objective of this study was to describe the German health care landscape and to assess hospital utilization with respect to PAD and ALI. Methods: Secondary data analysis of diagnosis-related group statistics data (2009–2018) provided by the German Federal Statistical Office. Inclusion of cases encoded by the International Classification of Diseases (ICD-10) codes for PAD and arterial embolism or thrombosis. Construction of line diagrams and choropleth maps to assess temporal trends and regional distributions. Results: A total of 2,589,511 cases (median age 72 years, 63% male) were included, of which 2,110,925 underwent surgical or interventional therapy. Overall amputation rate was 17%, with the highest rates of minor (28%) and major amputations (15%) in patients with tissue loss. In-hospital mortality (overall 4.1%) increased in accordance to Fontaine stages and was the highest in patients suffering arterial embolism or thrombosis (10%). Between 2009 and 2018, the annual number of PAD cases with tissue loss (Fontaine stage IV) increased from 97,092 to 111,268, whereby associated hospital utilization decreased from 2.2 million to 2.0 million hospital days. Hospital incidence and hospital utilization showed a clustering with the highest numbers in eastern Germany, while major amputation rate and mortality were highest in northern parts of Germany. Conclusions: Increased use of endovascular techniques was observed, while hospital utilization to treat PAD with tissue loss has decreased. This is despite an increased hospital incidence. Addressing socioeconomic inequalities and a more homogeneous distribution of dedicated vascular units might be advantageous in reducing the burden of disease associated with PAD and ALI.
Body Composition and Serum Concentration of Thyroid Hormones in Euthyroid Men and Women from General Population
Authors: Adamska Agnieszka , Raczkowski Andrzej , Stachurska Zofia , Kondraciuk Marcin , Krętowski Adam Jacek , Adamski Marcin , Kowalska Irina , Kamiński Karol Adam
Published: April 2022

Body composition, especially an increased amount of fat mass and decreased lean body mass, is connected with metabolic complications. Thyroid hormones can influence body composition pattern. To date, scarce data defining the relationships between thyroid hormones and parameters of body composition using dual-energy X-ray absorptiometry (DXA), especially in cohort studies, are available. Therefore, the aim of the present study was to investigate the relationships among serum concentrations of (thyroid-stimulating hormone (TSH), thyroid hormones, and distribution of fat tissue assessed using the DXA method in a euthyroid cohort from the Białystok PLUS study. We examined 582 euthyroid subjects who were divided into lean (body mass index (BMI) < 25 kg/m2) and overweight/obese (BMI ≥ 25 kg/m2) (84 lean men, 182 overweight/obese men, 160 lean women, and 156 overweight/obese women). Serum concentrations of TSH, free T3 (fT3), and free T4 (fT4) were assessed, and DXA was performed. We observed lower serum levels of fT4 (p = 0.03) and higher serum levels of fT3 (p = 0.04) in overweight/obese vs. lean men, whereas serum levels of TSH did not differ between these groups (p = 0.38). In lean men, we only observed a relationship between serum levels of TSH and visceral adipose tissue (VAT) (r = −0.24, p = 0.02). In overweight/obese men, we found that serum levels of fT3 were positively connected with total fat mass (r = 0.16, p = 0.02), android fat mass (r = 0.15, p = 0.03), and gynoid fat mass (r = 0.17, p = 0.01), but not with VAT (r = 0.03, p = 0.63). We did not observe differences in serum levels of TSH, fT3, and fT4 between lean and overweight/obese women. Additionally, we did not notice relationships between serum levels of thyroid hormones and fat in different regions estimated by DXA in lean and overweight/obese women (all p > 0.05). We concluded that the serum concentration of TSH is connected with VAT in lean men, whereas, in overweight/obese men, higher fT3 is connected with an increased fat amount. These associations are absent in women.
Cardiovascular Risks in Korean Patients with Gout: Analysis Using a National Health Insurance Service Database
Authors: Moon Ki Won , Kim Min Jung , Choi In Ah , Shin Kichul
Published: April 2022

Although several epidemiologic studies have shown the association between gout and cardiovascular outcomes, specific risk factors for developing cardiovascular diseases in Asian patients with gout are undisclosed. Thus, the purpose of this study was to investigate risks of cardiovascular outcomes and its related factors in Korean patients with gout. This retrospective clinical study used sampled cohort data from the National Health Insurance Service in Korea. Patients with gout were defined as subjects enlisted with an ICD-10 code (M10). Control patients were selected by frequency matching for age, sex, and index year. Primary outcomes included ischemic heart disease (IHD), congestive heart failure, cerebrovascular disease (CVD), or transient ischemic attack. We calculated the hazard ratio (HR) using Cox regression, adjusting potential confounders including age, sex, lifestyle habits, laboratory results, and medication. We identified 3306 patients with gout and an equal number of matched controls. Multivariate Cox regression analysis showed that gout patients had increased risks of IHD (HR: 1.860, 95% CI: 1.446–2.392), acute myocardial infarction (HR: 3.246, 95% CI: 1.460–7.217), and CVD (HR: 1.552, 95% CI: 1.177–2.036). Old age, current smoking, frequent alcohol intake, high low-density lipoprotein, and diabetes mellitus increased the risk of cardiovascular outcomes, yet hypouricemic agents decreased the risk of cerebrovascular diseases. Our data corroborate that it is crucial to identify and manage traditional cardiovascular risk factors alongside lowering urate levels in patients with gout.
1-Year Fixed-Regimen Bevacizumab Treatment in DME-Vascular Network Image Analysis in Optical Coherence Tomography Angiography Study
Authors: Hunt Magdalena , Wylęgała Adam , Wylęgała Edward , Teper Sławomir
Published: April 2022

Purpose: To evaluate the effectiveness of intravitreal bevacizumab treatment in patients with diabetic macular edema (DME) by assessing retinal changes using AngioTool software (version 0.6a(02.18.14), National Cancer Institute, Bethesda, Maryland). Methods: A total of 27 eyes in patients with treatment-naïve DME were included in this prospective study. OCT-A images with a scan area of 6 × 6 mm were obtained. The DME patients with a central macular thickness (CMT) of ≥300 µm received nine bevacizumab injections within 12 months. The demographic, systemic, and ocular parameters, including the best-corrected visual acuity (BCVA) and CMT, were assessed. Explant area, vessels area, vessels percentage area, total number of junctions, total vessels length, average vessels length, the total number of endpoints, and mean lacunarity in the superficial capillary plexus (SCP) were calculated by using AngioTool software. Results: Twenty-nine eyes of DME patients were subjected to the final analysis. Bevacizumab treatment reduced CMT from 401.84 ± 84.54 µm to 328.93 ± 87.17 µm and improved BCVA from 65.18 ± 8.21 at baseline to 72.63 ± 7.43 letters among participants of the study. The anti-VEGF therapy showed no statistically significant changes in parameters calculated by AngioTool software in the study group of patients. Conclusion: The fixed-regimen intravitreal bevacizumab therapy was effective in treating DME. AngioTool software is an additional tool that could be used to assess vascular networks. However, the use of OCTA is unlikely to alter DME treatment regimens significantly or to find significant predictors. Perhaps using wide-angle devices or software will give a complete picture of the disease and prove to be more helpful.
Premature Mortality in Type 2 Diabetes Mellitus Associated with Heart Failure and Chronic Kidney Disease: 20 Years of Real-World Data
Authors: Gavina Cristina , Carvalho Daniel Seabra , Dias Daniel Martinho , Bernardo Filipa , Martinho Hugo , Couceiro João , Santos-Araújo Carla , Dinis-Oliveira Ricardo Jorge , Taveira-Gomes Tiago
Published: April 2022

Introduction: Type 2 diabetes mellitus (T2D) increases the risk of heart failure (HF) and chronic kidney disease (CKD). Nonetheless, evidence of cardiovascular (CV) prognosis is relatively scarce in young T2D patients. Purpose: To estimate the risk of all-cause death, CV death, and non-fatal major CV events (MACEs) in T2D patients younger than 65 years old. Methods: We designed a retrospective cohort study using incident cases of either T2D, HF, or CKD in the population aged 40–65 years, from 1st January 2000 to 31st December 2019. Each individual was followed for up to one year. The primary analysis consisted of survival analysis with Cox proportional hazards to compare one-year risk of all-cause death, CV death, and MACEs between T2D without HF or CKD (T2D), T2D with HF (T2D-HF), and T2D with CKD (T2D-CKD) groups. Results: A total of 14,986 incident adult diabetic patients from the last two decades in our institution were included with an average age at cohort inclusion of 55–58 years old. Glycemic control was similar among groups. The adjusted hazard ratio (HR) of one-year all-cause death was 2.77 (95% CI: 2.26–3.40) for T2D-HF and 3.09 (2.77–3.45) for T2D-CKD compared with the baseline T2D risk. The highest event rate (T2D-CKD) was 0.15 per person-year. The adjusted HR of one-year CV death was 2.75 (95% CI: 2.19–3.46) for T2D-CKD and 2.59 (1.72–3.91) for T2D-HF. The non-fatal MACE risk was significantly increased in T2D-HF or T2D-CKD compared with T2D (2.82 (CI95%: 2.34–3.41) for T2D-CKD vs. 1.90 (CI95%: 1.66–2.17) for T2D-CKD) with a 32% event rate in non-fatal MACEs. Conclusions: Coexistence of HF or CKD is associated with increased premature mortality as well as non-fatal CV events in T2D patients under 65 years old.
Quantitative Analysis of Choriocapillaris Using Swept-Source Optical Coherence Tomography Angiography in Eyes with Angioid Streaks
Authors: Le Hoang Mai , Souied Eric H. , Halouani Safa , Borrelli Enrico , Chapron Thibaut , Querques Giuseppe , Miere Alexandra
Published: April 2022

Purpose: to quantitatively analyze choriocapillaris perfusion using swept-source optical coherence tomography angiography (SS-OCTA) in eyes presenting with angioid streaks in comparison with control eyes. Methods: Macular 6 × 6 mm SS-OCTA scans were retrospectively analyzed in eyes with angioid streaks and in control eyes. En face choriocapillaris flow images were compensated with en face choriocapillaris structure images, followed by the Phansalkar local thresholding method (with a window radius of four and eight pixels). Quantitative analysis was performed in the four peripheral 1 × 1 mm corners of the 6 × 6 mm SS-OCTA image to include equidistant and comparable regions. The percentage of flow deficits (FD%), the number and size of the flow deficits (FDs) and the total area of FDs were then calculated. Results: 54 eyes of 31 patients were included in the study: 27 eyes diagnosed with angioid streaks and 27 controls. Analysis of the four 1 × 1 mm peripheral corners of the 6 × 6 mm SS-OCTA image showed that eyes with angioid streaks had a higher FD% compared to the control group (47.62 ± 8.06 versus 38.90 ± 6.38 using a radius of four pixels (p < 0.001); 48.37 ± 7.65 versus 39.66 ± 6.51 using a radius of eight pixels (p < 0.001). The average size of FDs as well as the total area size of the FDs were significantly higher in eyes with angioid streaks compared to control eyes (p < 0.001). Eyes with angioid streaks present reduced choriocapillaris flow compared to control eyes. Decreased choriocapillaris perfusion may contribute, among other factors, to the development of neovascularization and atrophy in patients with angioid streaks.
InTrathecal mORphine, traNsversus Abdominis Plane Block, and tramaDOl Infusion for Catheter-Related Bladder Discomfort in Patients Undergoing Robot-Assisted Laparoscopic Prostatectomy (TORNADO): A Pilot Prospective Controlled Study
Authors: Russo Andrea , Romanò Bruno , Papanice Domenico , Cataldo Andrea , Gandi Carlo , Vaccarella Luigi , Totaro Angelo , Sacco Emilio , Bassi Pierfrancesco , Aceto Paola , Sollazzi Liliana
Published: April 2022

Catheter-related bladder discomfort (CRBD), affecting surgical patients requiring large catheters, is often intolerable. In this prospective controlled study, we compared the efficacy of three analgesic approaches in the management of CRBD. Here, 33 patients undergoing robot-assisted laparoscopic prostatectomy (RALP) were allocated to the following three groups: intrathecal morphine (IM), transversus abdominis plane block (TAP), and tramadol intravenous infusion (TI). The primary outcome was CRBD assessed at admission in the recovery room (RR) (T0), and 1 h (T1), 12 h (T2), and 24 h (T3) after surgery. The secondary outcomes included the following: Aldrete score; postoperative pain, measured with a numerical rate scale (NRS) at T0, T1, T2, and T3; postoperative opioid consumption; and flatus. The patients of the IM group showed significantly lower CRBD values over time compared to the patients of the TI group (p = 0.006). Similarly, NRS values decreased significantly over time in patients receiving IM compared to patients treated with TI (p < 0.0001). Postoperative nausea and vomiting did not differ among the three groups. Postoperative opioid consumption was significantly lower in the IM group compared to the other two groups. Most patients of the IM group (9 of 11) had flatus on the first postoperative day. In conclusion, IM may prevent CRBD and reduce pain perception and postoperative opioid consumption and expedite bowel function recovery.
Adaptive Real-Time Object Detection for Autonomous Driving Systems
Authors: Hemmati Maryam , Biglari-Abhari Morteza , Niar Smail
Published: April 2022

Accurate and reliable detection is one of the main tasks of Autonomous Driving Systems (ADS). While detecting the obstacles on the road during various environmental circumstances add to the reliability of ADS, it results in more intensive computations and more complicated systems. The stringent real-time requirements of ADS, resource constraints, and energy efficiency considerations add to the design complications. This work presents an adaptive system that detects pedestrians and vehicles in different lighting conditions on the road. We take a hardware-software co-design approach on Zynq UltraScale+ MPSoC and develop a dynamically reconfigurable ADS that employs hardware accelerators for pedestrian and vehicle detection and adapts its detection method to the environment lighting conditions. The results show that the system maintains real-time performance and achieves adaptability with minimal resource overhead.
Autonomous Water Sampler for Oil Spill Response
Authors: Gomez-Ibanez Daniel , Kukulya Amy L. , Belani Abhimanyu , Conmy Robyn N. , Sundaravadivelu Devi , DiPinto Lisa
Published: April 2022

A newly developed water sampling system enables autonomous detection and sampling of underwater oil plumes. The Midwater Oil Sampler collects multiple 1-L samples of seawater when preset criteria are met. The sampler has a hydrocarbon-free sample path and can be configured with several modules of six glass sample bottles. In August 2019, the sampler was deployed on an autonomous underwater vehicle and captured targeted water samples in natural oil seeps offshore Santa Barbara, CA, USA.
Influence of End Wall Clearance on Guide Vane Self-Excited Vibrations at Small Openings during Pump Mode’s Starting Up Process of a Reversible Pump Turbine
Authors: Liang Quanwei , Kang Wenzhe , Zhou Lingjiu , Wang Zhengwei
Published: April 2022

Unstable guide vane torsional mode self-excited vibrations that occur at small guide vane openings during the transient operations with pump flow, such as the starting and closing of the pump mode, are considered to have potentially severe consequences, such as guide vane slippage or damage to the link and lever mechanism. Related site tests have indicated that the end wall clearance of a guide vane may have important influences on torsional mode self-excited vibrations. In this paper, numerical investigations, which were based on computational fluid dynamics (CFD) with a single degree of freedom (1DOF) mass-spring oscillator, were carried out on a prototype high-head reversible pump turbine. The results showed that the guide vane self-excited vibrations are unstable under steady-state conditions and during the pump mode’s starting up process for cases with small end wall clearances. In addition, the critical conditions of self-excitation instability under steady-state conditions have larger safety margins than those during the pump mode’s starting up process. After further discussion, it was concluded that increasing the end wall clearance to suppress unstable guide vane self-excited vibration is unreliable due to the complexity and randomness of the initial vibration excitations.
DCA-Based Collision Avoidance Path Planning for Marine Vehicles in Presence of the Multi-Ship Encounter Situation
Authors: Yu Jiagen , Liu Zhengjiang , Zhang Xianku
Published: April 2022

The problem of ship collision avoidance path planning is one of the key problems in the ship motion control field. Aiming at the high computational time problem of path planning in multi-ship encounter situations and the impact of the target ship’s action changes on path planning, this paper proposes a dynamic path-planning method based on dynamic cluster analysis (DCA), which is used to dynamically cluster target ships with similar attributes into a group ship, reducing the number of calculated targets and improving the efficiency of path planning. Taking into full consideration the action requirements of the International Regulations for Preventing Collisions at Sea (COLREGs), the course alteration action matrix (CAAM) for collision avoidance is established to limit the space of candidate solutions. On the basis of the rapid optimization capability of the deterministic optimization algorithm (DOA), a dynamic monitoring mechanism is introduced to establish a multi-ship encounter intelligent collision avoidance decision-making model that meets the needs of real-time collision avoidance. The simulation results showed that the method can obtain a dynamic collision avoidance path that is safe and feasible.
Antidepressant Treatment and Manic Switch in Bipolar I Disorder: A Clinical and Molecular Genetic Study
Authors: Chen Chih-Ken , Wu Lawrence Shih-Hsin , Huang Ming-Chyi , Kuo Chian-Jue , Cheng Andrew Tai-Ann
Published: April 2022

Affective switch is an important clinical issue when treating bipolar disorder. Though commonly seen in clinical practice, the benefits of prescribing antidepressants for bipolar depression are still controversial. To date, there have been few genetic studies and no genome-wide association study (GWAS), focusing on manic switch following bipolar depression. This study aims to investigate the effects of individual genomics and antidepressant medication on the risk of manic switch in bipolar I disorder (BPI). A total of 1004 patients with BPI who had at least one depressive episode with complete data on antidepressant treatment and outcome were included. Clinical assessment of mania and depression was performed by trained psychiatric nurses and psychiatrists using the Chinese version of the Schedules for Clinical Assessment in Neuropsychiatry (SCAN), and the diagnosis of BPI was made according to DSM-IV criteria. Manic switch was defined as a manic episode occurring within eight weeks of remission from an acute depressive episode. The age at first depressive episode of the study patients was 30.7 years (SD 12.5) and 56% of all patients were female. GWAS was carried out in a discovery group of 746 patients, followed by replication in an independent group of 255 patients. The top SNP rs10262219 on chromosome 7 showed the strongest allelic association with manic switch (p = 2.21 × 10−7) in GWAS, which was however not significantly replicated. Antidepressant treatment significantly (odds ratio 1.7; 95% CI 1.3–2.2; p < 0.001) increased the risk of manic switch. In logistic regression analysis, the CC genotype of rs10262219 (odds ratio 3.0; 95% CI 1.7–5.2) and antidepressant treatment (odds ratio 2.3; 95% CI 1.4–3.7) significantly increased the risk of manic switch with a joint effect (odds ratio 5.9; 95% CI 3.7–9.4). In conclusion, antidepressant medication and rs10262219 variants jointly increased the risk of manic switch after bipolar depression.
Body Representation in Patients with Severe Spinal Cord Injury: A Pilot Study on the Promising Role of Powered Exoskeleton for Gait Training
Authors: Maggio Maria Grazia , Naro Antonino , De Luca Rosaria , Latella Desiree , Balletta Tina , Caccamo Lory , Pioggia Giovanni , Bruschetta Daniele , Calabrò Rocco Salvatore
Published: April 2022

Patients with spinal cord injury (SCI) complain of changes in body representation, potentially leading to negative physical and psychological consequences. The purpose of our study is to evaluate the effects of robotic training with the Ekso-GT on body representation (BR) and on the quality of life in patients with SCI. The trial was designed as a pilot, assessor-blinded study. Forty-two inpatients with a diagnosis of SCI, classified as either American Spinal Cord Injury Association Impairment Scale (AIS), were enrolled in this study and randomized into either a control (CG: n = 21) or an experimental (EG: n = 21) group. Patients in the EG received rehabilitation training with the Ekso-GT device, whereas the CG patients were trained with conventional physical therapy (CPT), which consisted of physical and occupational therapy and psychological support. We considered as a primary outcome the modified Body Uneasiness Test (MBUT), focusing on three specific subscales on the patient’s perception of BR, i.e., the Global Severity Index (MBUT-GSI), which is an indicator of body suffering; the Positive Symptom Distress Index (MBUT-PSDI) that expresses an individual’s psychological distress; and the Lower Limb MBUT (MBUT-LL), which indicates the subject’s perception of their thighs/legs. The Short-Form-12 Health Status Questionnaire (SF12) and the Beck’s Depression Inventory (BDI) were used as secondary outcomes to evaluate the effect of the training on the quality of life and the psychological status. Non-parametric statistical analysis showed that the effect of the two treatments was significantly different on MBUT (BR), SF-12 (quality of life), and, partially, BDI (mood). Particularly, patients belonging to the EG achieved a major improvement in nearly all test scores compared to those in the CG. Our data suggest that the Ekso-GT training could be helpful in achieving positive changes in BR in patients with chronic SCI, especially in reducing psychological distress (PSDI) and thigh/leg perception (MBUT-LL) with an overall improvement in quality of life (SF-12).
A Survey of the Accounting Industry on Holdings of Cryptocurrencies in Xiamen City, China
Authors: Yan Huqin , Yan Kejia , Gupta Rakesh
Published: April 2022

This is the first survey conducted in China on the holding of cryptocurrencies. Although cryptocurrencies have existed in the world for more than a decade, because the exchange of cryptocurrencies is banned in China, there is no guidance on the holding of cryptocurrencies in China’s accounting standards. Moreover, although the exchange of cryptocurrencies is prohibited by the Chinese government, holdings of cryptocurrencies by Chinese entities and individuals cannot be prevented. Thus, we conducted a survey in investors’ attitudes towards cryptocurrencies in Xiamen City, a special economic zone (SEZ) and a pilot free trade zone (FTZ) in China. The survey respondents commonly defined cryptocurrencies as investments (45%), inventories (19%), and intangible assets (36%). A total of 84% of respondents stated that the value of a cryptocurrency should be represented by a fair value. These results are similar to those obtained in a survey by The Digital Assets Accounting Consortium (DAAC), but different to the tentative agenda decision of the International Financial Reporting Standards Interpretations Committee (IFRSIC). Additionally, 65% of respondents stated that they prefer to accept cryptocurrencies as cash equivalent currencies, and these cash equivalent currencies were considered to have two main functions: a medium of exchange (56%) and a monetary unit for pricing goods and services (52%).
Land Degradation Neutrality: State and Trend of Degradation at the Subnational Level in Mexico
Authors: Arroyo Itzel , Cervantes Virginia , Tamaríz-Flores Víctor , Castelán Rosalía
Published: April 2022

Identifying degraded lands and degradation trends is essential to determine measures that contribute to avoiding, reducing, and reversing the rate of deterioration of natural resources. In this study, we assessed the state and trend of degradation in Ixtacamaxtitlan, Puebla, Mexico, by determining the spatial and temporal changes of three indicators, Land Cover (LC), Land Productivity Dynamics (LPD), and Soil Organic Carbon (SOC), during the period 2000–2015, using global data proposed by the Convention to Combat Desertification for the implementation of Land Degradation Neutrality (LDN). The results showed increases in croplands (6.89%) and a reduction in grasslands (9.09%), with this being the transition that presents the most significant extension in the territory. The LPD is the indicator where the most deterioration was observed, and due to negative changes in LC, SOC losses were estimated at more than 7000 tons in the study period. The proportion of degraded land was 19% of approximately 567.68 km2 of Ixtacamaxtitlan’s surface. Although the municipality presents incipient degradation and only a tiny part showed improvement, identifying areas with degradation processes in this work will favor degradation monitoring and the adequate planning and application of restoration measures in the local context to promote the path towards LDN.
The Seeds of the Noun–Verb Distinction in the Manual Modality: Improvisation and Interaction in the Emergence of Grammatical Categories
Authors: Motamedi Yasamin , Montemurro Kathryn , Abner Natasha , Flaherty Molly , Kirby Simon , Goldin-Meadow Susan
Published: April 2022

The noun–verb distinction has long been considered a fundamental property of human language, and has been found in some form even in the earliest stages of language emergence, including homesign and the early generations of emerging sign languages. We present two experimental studies that use silent gesture to investigate how noun–verb distinctions develop in the manual modality through two key processes: (i) improvising using novel signals by individuals, and (ii) using those signals in the interaction between communicators. We operationalise communicative interaction in two ways: a setting in which members of the dyad were in separate booths and were given a comprehension test after each stimulus vs. a more naturalistic face-to-face conversation without comprehension checks. There were few differences between the two conditions, highlighting the robustness of the paradigm. Our findings from both experiments reflect patterns found in naturally emerging sign languages. Some formal distinctions arise in the earliest stages of improvisation and do not require interaction to develop. However, the full range of formal distinctions between nouns and verbs found in naturally emerging language did not appear with either improvisation or interaction, suggesting that transmitting the language to a new generation of learners might be necessary for these properties to emerge.
Prostate MRI: Is Endorectal Coil Necessary?—A Review
Authors: Lee Grace , Oto Aytekin , Giurcanu Mihai
Published: April 2022

To assess the necessity of endorectal coil use in 3 Tesla (T) prostate magnetic resonance imaging (MRI), a literature review comparing the image quality and diagnostic performance with an endorectal coil (ERC) and a without endorectal coil (NERC), with a phased array coil or a wearable perineal coil (WPC), was performed. A PubMed search of 3T prostate MRI using an endorectal coil for studies published until 31 July 2021 was performed. A total of 14 studies comparing 3T prostate MRI with and without endorectal coil use were identified. The quality scores and diagnostic performances were recorded for each study. In total, five studies compared image quality; five studies compared quality and performance; and four studies compared performance of detection, size of detected lesions, accuracy of cancer localization, and aggressiveness/staging. The use of an endorectal coil improved image quality with a higher overall signal to noise ratio, posterior and peripheral zone signal to noise ratio, high b-value attenuation diffusion coefficient (ADC) signal to noise ratio, and contrast to noise ratio. Endorectal coil use improved subjective image quality for anatomic detail on T2 weighted images (T2WI) and diffusion weighted images (DWI). Endorectal coil use had less motion artifact on DWI than non-endorectal coil use, but produced a higher occurrence of other artifacts on DWI. Endorectal coils had higher sensitivity, specificity, and positive predictive value (PPV) in the detection of overall and index lesions, as well as smaller and less aggressive lesions, missing fewer and smaller lesions than non-endorectal coils. Endorectal coils had higher sensitivity than non-endorectal coils in localizing and staging lesions. Endorectal coils improved quantitative and qualitative image quality and diagnostic performance in the detection of smaller and less aggressive cancers in 3T prostate MRI.
Martensitic Transformation and Magnetic-Field-Induced Strain in High-Entropy Magnetic Memory Alloy Ni20Mn20Ga20Gd20Co20 by Hot-Magnetic Drawing
Authors: Ju Jia , Fang Mengfei , Shuai Liguo , Yin Kang
Published: April 2022

The wires with chemical composition Ni20Mn20Ga20Gd20Co20 were prepared by hot-magnetic drawing and the microstructure evolution characteristics, martensitic transformation and MFIS process were investigated in detail, respectively. The results showed that a multiphase structure with γ phase and martensite was observed in samples when the magnetic field was 0 T to 0.2 T during the hot-magnetic drawing process. With the magnetic field increased to 0.5 T, due to the atomic diffusion by severe thermoplastic deformation and high external magnetic field, a single-phase structure with L10 type twin martensite was found in the sample. Moreover, an obvious increasing trend in martensitic transformation temperature in the sample was found by the enhancement of the magnetic field during the hot-magnetic drawing process. The highest phase transition temperature rose to about 600 °C when the magnetic field reached 0.5 T. Finally, the property of SME and MFIS in the sample can be enhanced by the magnetic field increasing during the hot-magnetic drawing process, excellent performance of SME was obtained at low total strain, and MFIS was achieved at 4.47% at a magnetic field of 8007 Oe in the sample in the 0.5 T magnetic field during the hot-magnetic drawing process.
A Three-Dimensional Comprehensive Numerical Model of Ion Transport during Electro-Refining Process for Scrap-Metal Recycling
Authors: Liu Chang , Li Guangqiang , Zhang Lifeng , Wang Qiang , Wang Qiang
Published: April 2022

A transient three-dimensional comprehensive numerical model was established to study ion transport caused by diffusion, convection, and electro-migration in the electro-refining process for scrap-metal recycling. The Poisson–Nernst–Planck equations were used to define ion transport within the electrolyte, while the Naiver–Stokes equations and the energy equation were employed to describe fluid flow and heat transfer. In addition, the Butler-Volmer formulation was used to represent the kinetics of the electrochemical reaction. The comparison between the measured and simulated data indicates the reliability of the model. Under the action of diffusion and electro-migration, the positive copper ion moves from the anode to the cathode, while the negative sulfate ion migrates in the opposite direction. The distribution of the ion concentration, however, greatly changes if the fluid flow is taken into account. The ion concentration around the anode and the rate of the electrochemical reaction that occurs at the anode surface are reduced by the fluid flow. The proposed computational framework offers a valuable basis for future research and development in the field of scrap-metal recycling technology.
Hydration and Properties of Cement in the Belite-Ye′elimite-Ternesite System
Authors: Wang Guoling , Huang Xiaofei , Wu Yufeng , Zhang Qian , Ma Suhua , Li Weifeng
Published: April 2022

Energy consumption and carbon emissions are lower in the production of belite-ye′elimite-ternesite (C2S-C4A3$-C5S2$, BYT) clinker than Portland cement (PC) clinker. BYT cement can combine the early strength of CSA cements and the durability of belite cements. X-ray diffraction, mercury intrusion porosimetry, isothermal conduction calorimetry and scanning electron microscope were conducted to investigate the hydration process of BYT cement. The hydration products of BYT cement include mainly ettringite, strätlingite and some amorphous AH3 (aluminum hydroxide). Ternesite did prove an early reactivity in BYT cement. The reaction of ternesite with AH3 occurs on the surface of ternesite. Ternesite delays the second heat flow peak of ye′elimite. The strength of BYT cement containing 10% ternesite in the prepared clinker exceeds that of other cement at all ages.
Low-Temperature, Efficient Synthesis of Highly Crystalline Urchin-like Tantalum Diboride Nanoflowers
Authors: Liu Delei , Liu Jianghao , Ye Peikan , Zhang Haijun , Zhang Shaowei
Published: April 2022

Urchin-like tantalum diboride (TaB2) nanoflowers were successfully synthesized via a high-efficiency and energy-saving methodology, molten-salt and microwave co-modified boro/carbothermal reduction, using less expensive B4C as a reducing agent. By taking advantage of the synergistic effects of the molten-salt medium and microwave heating conditions, the onset formation temperature of TaB2 was drastically reduced to below 1000 °C, and phase-pure powders of TaB2 nanoflowers were obtained at temperatures as low as 1200 °C within only 20 min. Notably, the present temperature conditions were remarkably milder than those (>1500 °C for several hours) required by conventional reduction methods, which use the strong, but expensive, reducing agent, elemental boron. The resulting urchin-like TaB2 nanoflowers consisted of numerous uniform single-crystalline nanowires with lengths up to 4.16 μm, and high aspect ratios >10. This result indicated that the as-synthesized urchin-like TaB2 nanoflowers possessed high specific surface area and anisotropic morphology, which were favorable not only for sintering, but also for toughening their bulk counterparts.
Valorization of β-Chitin Extraction Byproduct from Cuttlefish Bone and Its Application in Food Wastewater Treatment
Authors: Nouj Nisrine , Hafid Naima , El Alem Noureddine , Buciscanu Ingrid Ioana , Maier Stelian Sergiu , Samoila Petrisor , Soreanu Gabriela , Cretescu Igor , Stan Catalina Daniela
Published: April 2022

The nontoxicity, worldwide availability and low production cost of cuttlefish bone products qualify them an excellent biocoagulant to treat food industry wastewater. In this study, cuttlefish bone liquid waste from the deproteinization step was used as a biocoagulant to treat food industry wastewater. This work concerns a waste that has never before been investigated. The objectives of this work were: the recovery of waste resulting from cuttlefish bone deproteinization, the replacementof chemical coagulants with natural ones to preserve the environment, and the enhancement ofthe value of fishery byproducts. A quantitative characterization of the industrial effluents of a Moroccan food processing plant was performed. The physicochemical properties of the raw cuttlefish bone powder and the deproteinization liquid extract were determined using specific analysis techniques: SEM/EDX, FTIR, XRD and 1H-NMR. The protein content of the deproteinization liquid was determined by OPA fluorescent assay. The zeta potential of the liquid extract was also determined. The obtained analytical results showed that the deproteinization liquid waste contained an adequate amount of soluble chitin fractions that could be used in food wastewater treatment. The effects of the coagulant dose and pH on the food industrial effluents were studied to confirm the effectiveness of the deproteinization liquid extract. Under optimal conditions, the coagulant showed satisfactory results. Process optimization was performed using the Box–Behnken design and response surface methodology. Thus, the optimal removal efficiencies predicted using this model for turbidity (99.68%), BOD5 (97.76%), and COD (82.92%) were obtained at a dosage of 8 mL biocoagulant in 0.5 L of food processing wastewater at an alkaline pH of 11.
Synthesis and Characterization of a Crystalline Imine-Based Covalent Organic Framework with Triazine Node and Biphenyl Linker and Its Fluorinated Derivate for CO2/CH4 Separation
Authors: Bügel Stefanie , Hähnel Malte , Kunde Tom , de Sousa Amadeu Nader , Sun Yangyang , Spieß Alex , Beglau Thi Hai Yen , Schmidt Bernd M. , Janiak Christoph
Published: April 2022

A catalyst-free Schiff base reaction was applied to synthesize two imine-linked covalent organic frameworks (COFs). The condensation reaction of 1,3,5-tris-(4-aminophenyl)triazine (TAPT) with 4,4′-biphenyldicarboxaldehyde led to the structure of HHU-COF-1 (HHU = Heinrich-Heine University). The fluorinated analog HHU-COF-2 was obtained with 2,2′,3,3′,5,5′,6,6′-octafluoro-4,4′-biphenyldicarboxaldehyde. Solid-state NMR, infrared spectroscopy, X-ray photoelectron spectroscopy, and elemental analysis confirmed the successful formation of the two network structures. The crystalline materials are characterized by high Brunauer–Emmett–Teller surface areas of 2352 m2/g for HHU-COF-1 and 1356 m2/g for HHU-COF-2. The products of a larger-scale synthesis were applied to prepare mixed-matrix membranes (MMMs) with the polymer Matrimid. CO2/CH4 permeation tests revealed a moderate increase in CO2 permeability at constant selectivity for HHU-COF-1 as a dispersed phase, whereas application of the fluorinated COF led to a CO2/CH4 selectivity increase from 42 for the pure Matrimid membrane to 51 for 8 wt% of HHU-COF-2 and a permeability increase from 6.8 to 13.0 Barrer for the 24 wt% MMM.
Physical Modeling and Structural Properties of Small-Scale Mine Ventilation Networks
Authors: Novella-Rodriguez David-Fernando , Witrant Emmanuel , Commault Christian
Published: April 2022

This work is devoted to the modeling and structural analysis of ventilation networks in small-scale mines using a physically oriented modeling method that ensures power conservation. Small-scale mines are common in the mineral extraction industry of underdeveloped countries and their physical characteristics are taken into account in the modeling process. The geometrical topology of the ventilation network in addition with the conservation laws of the fluid distribution along the network are considered in order to obtain a simple modeling methodology. Non-linear characteristics of the interconnected fluid dynamics represent a challenge to determine significant features of the system from a control point of view. Observability and controllability properties are analyzed by considering the structural systems approach. An structural analysis provides information based on the network topology independently of the mine parameters allowing the number of sensors and actuators to be reduced while also preserving the observability and controllability of the ventilation system. Experimental results are provided by building a small-scale ventilation network benchmark to evaluate the proposed model and its properties.
New-Onset Atrial Fibrillation and Early Mortality Rate in COVID-19 Patients: Association with IL-6 Serum Levels and Respiratory Distress
Authors: Bagnato Gianluca , Imbalzano Egidio , Aragona Caterina Oriana , Ioppolo Carmelo , Di Micco Pierpaolo , La Rosa Daniela , Costa Francesco , Micari Antonio , Tomeo Simona , Zirilli Natalia , Sciacqua Angela , D’Angelo Tommaso , Cacciola Irene , Bitto Alessandra , Irrera Natasha , Russo Vincenzo , Roberts William Neal , Gangemi Sebastiano , Versace Antonio Giovanni
Published: April 2022

Background and objectives: COVID-19 is associated with an aberrant inflammatory response that may trigger new-onset cardiac arrhythmias. The aim of this study was to assess the mortality risk in hospitalized COVID-19 patients according to IL-6 serum levels and new-onset atrial fibrillation (AF) according to PaO2/FiO2 stratification. Materials and Methods: 175 COVID-19 patients (25 new-onset AF, 22 other types of AF and 128 no-AF) were included in this single-center, retrospective study; clinical and demographic data, vital signs, electrocardiograms and laboratory results were collected and analyzed. The primary outcome of the study was to evaluate the mortality rate in new-onset AF patients according to IL-6 serum levels and PaO2/FiO2 stratification. Results: The incidence of new-onset AF in the study population was 14.2%. Compared to the no-AF group, new-onset AF patients were older with a positive history of chronic kidney disease and heart failure, had higher IL-6, creatinine and urea serum levels whereas their platelet count was reduced. After PaO2/FiO2 stratification, 5-days mortality rate was higher in new-onset AF patients compared to patients with other types of AF and no-AF patients, and mortality risk increases 5.3 fold compared to no-AF (p = 0.0014) and 4.8 fold compared to other forms of AF (p = 0.03). Conclusions: New-onset AF is common in COVID-19 patients and is associated with increased IL-6 serum levels and early mortality. Further studies are needed to support the use of IL-6 as an early molecular target for COVID-19 patients to reduce their high rate of mortality.
Hepatitis B Virus Genotypes and Antiviral Resistance Mutations in Romanian HIV-HBV Co-Infected Patients
Authors: Sultana Camelia , Casian Mihnea , Oprea Cristiana , Ianache Irina , Grancea Camelia , Chiriac Daniela , Ruta Simona
Published: April 2022

Background and Objectives: Romania has one of the highest prevalence of hepatitis B virus (HBV) infection in human immunodeficiency virus (HIV) patients, mostly in those parenterally infected during childhood; nevertheless, there are scarce data on the virological profile of co-infection. The objective of this study was to assess the prevalence of HBV genotypes and antiviral resistance-associated mutations (RAMs) in these co-infected patients, in order to monitor the viral factors associated with the evolution of liver disease. Materials and Methods: HBV genotypes and RAMs were detected using nested PCR and line probe assays (INNO-LiPA HBV genotyping assay, and INNO-LiPA HBV DR v2, Innogenetics). Results: Out of 117 co-infected patients, 73.5% had detectable HBV-DNA, but only 38.5% presented an HBV viral load >1000 IU/mL. HBV genotype A was present in 66.7% of the cases and was dominant in patients parenterally infected during early childhood, who experienced multiple treatment regimens, with a mean therapy length of 15.25 years, and present numerous mutations associated with lamivudine (LAM) resistance, but very rarely active liver disease. HBV genotype D was detected in 33.3% of the cases, mostly in recently diagnosed injecting drug users who are treatment naïve, but, nevertheless, present RAMs in 63.5% of the cases, suggesting transmitted drug resistance, and display more frequently advanced liver fibrosis (36.1% vs. 12.3%; p = 0.033). The most frequently encountered RAMs are M204V/I: 48.8%, L180M: 33.3%, L80V: 28.8%, and V173L: 42.2%. There are no significant differences in the distribution of RAMs in patients infected with different HBV genotypes, except for the L80V and N236T mutations, which were more frequently found in HBV genotype A infections (p = 0.032 and p = 0.004, respectively). Conclusions: HBV genotypes A and D are the only genotypes present in HIV–HBV co-infected patients from Romania, with different distributions according to the infection route, and are frequently associated with multiple RAMs, conferring extensive resistance to LAM.
Complementary Powerful Techniques for Investigating the Interactions of Proteins with Porous TiO2 and Its Hybrid Materials: A Tutorial Review
Authors: Dong Yihui , Lin Weifeng , Laaksonen Aatto , Ji Xiaoyan
Published: April 2022

Understanding the adsorption and interaction between porous materials and protein is of great importance in biomedical and interface sciences. Among the studied porous materials, TiO2 and its hybrid materials, featuring distinct, well-defined pore sizes, structural stability and excellent biocompatibility, are widely used. In this review, the use of four powerful, synergetic and complementary techniques to study protein-TiO2-based porous materials interactions at different scales is summarized, including high-performance liquid chromatography (HPLC), atomic force microscopy (AFM), surface-enhanced Raman scattering (SERS), and Molecular Dynamics (MD) simulations. We expect that this review could be helpful in optimizing the commonly used techniques to characterize the interfacial behavior of protein on porous TiO2 materials in different applications.