bluuebunny/crossref_metadata_2025 huggingface dataset:
creación artística en la transformación digital. Re-significar la etiqueta Arte Contemporáneo en la Era Global.
Authors: Labella Martínez Antonio
Published: December 2023

En el presente artículo se expone el análisis realizado sobre la vigencia de la etiqueta Arte Contemporáneo según su capacidad para englobar las creaciones artísticas propias de un nuevo periodo histórico denominado como La Contemporaneidad. El estudio toma como punto de partida el influyente cuestionamiento que realizó en el Giorgio Agamben sobre el significado de ser Contemporáneo y examina algunos de los principales debates críticos que fueron realizados por artistas y académicos interesados en torno a la re-significación de la categoría artística a raíz del planteamiento. El artículo concluye con la exposición de una serie de líneas de investigación que son capaces de aportar datos concretos sobre el ecosistema de la creación artística actual y que están favoreciendo el estudio de la creación artística de la Contemporaneidad, basándose en la aplicación de herramientas digitales y metodologías relacionadas con la Analítica Cultural.
Retrato de una mujer en llamas (Céline Sciamma, 2019): Una relectura reivindicativa del papel de la mujer en la historia a través de las artes
Authors: Padilla Aguilera Tania , Ruiz Pérez Silvia
Published: December 2023

Retrato de una mujer en llamas, de   la directora francesa Céline Sciamma (2019), representa la culminación de su trayectoria como cineasta. Esta se enmarca siempre bajo unos parámetros ideológicos y reivindicativos planteados desde las teorías feministas y queer. En este trabajo realizaremos un estudio que abarca aspectos como la reescritura (Pérez Bowie, Pardo  García, Chatman) que supone este filme. Veremos cómo se reconstruye la historia mediante una realidad utópica que normaliza el empoderamiento femenino, en respuesta al enmudecimiento que las mujeres artistas e independientes han sufrido durante siglos. Así, relacionaremos esta emancipación femenina con los discursos queer y feministas  radicales de Butler y Wittig. A su vez, analizaremos los intertextos que intervienen en los mecanismos cinematográficos de esta obra, cuyo análisis sentará sus bases en los presupuestos planteados por Kristeva y Barthes y, en última instancia, cómo este proceso es sintetizado por los estudios de De Lauretis. En definitiva, demostraremos que Sciamma elabora un filme que logra      deconstruir los roles de género establecidos, además de visibilizar y naturalizar las relaciones homosexuales y normalizar cuestiones intrínsecamente femeninas consideradas tabú incluso en la sociedad actual.
misión fotográfica de Tomás Camarillo en Guadalajara: Patrimonio, paisaje y retrato
Authors: Iniesta Sepúlveda Víctor
Published: December 2023

La fotografía ha constituido desde su invención un medio privilegiado para registrar bienes patrimoniales y manifestaciones culturales. Este artículo estudia la obra de Tomás Camarillo (1879-1954), que testimonió de manera exhaustiva la provincia de Guadalajara, su naturaleza y cultura. Con el fin de estimar el valor de su aportación documental y creativa, se analizan fotografías y ejemplares inéditos. Dentro del amplio repertorio visual, se presta especial atención a paisajes, vistas de pueblos, obras públicas, escenas costumbristas, retratos y manifestaciones del patrimonio inmaterial. También se reflexiona sobre los usos documentales, turísticos y políticos de la colección.
escultor Jacinto Pimentel (h. 1600-1676): Nuevos datos para su biografía
Authors: Martín Francisco José
Published: December 2023

El propósito del presente artículo es enriquecer la biografía del escultor Jacinto Pimentel con nuevos datos genealógicos. Aunque casó en tres ocasiones, tan solo tuvo descendencia con la primera de sus esposas, desarrollándose una prolija descendencia por medio de sus tres hijas: Damasia, María y Teresa. En segundo lugar, se da a conocer el testamento de su tercera mujer, María Guerrero, cuyos datos reflejados en el mismo son de gran interés para comprender la última etapa vital del imaginero.
Del Racionalismo al Neorrománico. Enrique Crespo y un sanatorio-residencia zamorano entre la vanguardia y el revival
Authors: García-Lozano Rafael Ángel
Published: December 2023

Estudiamos como paradigma un edificio que, además de alterar su lenguaje formal debido a sus distintas reformas, también lo hizo en virtud de sus usos. Así, la primitiva Residencia Sanitaria, que consituyó uno de los raros ejemplos del racionalismo arquitectónico en una capital tradicional y modesta como era Zamora cuando fue construida en el primer tercio del siglo XX, dio paso a un centro religioso que mantuvo su carácter salvo en su nueva capilla. Su última adecuación neorrománica de los años 70 introdujo un nuevo lenguaje, permaneciendo, no obstante, los elementos racionalistas aunque epidémicamente transformados por el uso. Esta amalgama de lenguajes y sus sucesivas reformas desfiguraron una arquitectura extraordinaria pero que conserva sus principales valores mientras permanece –como tantas otras- expuesta a su desconsideración y las dudas de su perduración.
Catedral de Cartagena de Indias, Colombia, su proceso evolutivo en el tiempo
Authors: Zabaleta Ricardo
Published: December 2023

La arquitectura de valor patrimonial, como un acto de indiscutible permanencia en el tiempo, tiene la particularidad de ser el reflejo fiel del pensamiento humano y el transcurrir de su memoria histórica de generación en generación. La Catedral de Cartagena de Indias, pieza fundamental en los procesos de la colonización de almas en épocas virreinales, ha sido testigo de muchos acontecimientos, siendo a su vez objeto de múltiples transformaciones que han sido impronta de viejos tiempos y que han caracterizado su proceso evolutivo acorde a las dinámicas de la ciudad. En este artículo mostramos ese proceso y las modificaciones que le han aportado, no solo a su arquitectura, sino también al constructo social y la memoria histórica que ella representa para todos los cartageneros y Colombia en general.
Alegoría del Monte Carmelo en una pintura de Luis Juárez
Authors: Cruz Lazcano Victor
Published: December 2023

Uno de los portentos marianos que distinguió a la orden de los carmelitas fue la entrega del escapulario a san Simón Stock. Este privilegio distinguió a la orden de las demás otorgándole prestigio. Y, en consecuencia, fue reproducida en pinturas a lo largo y ancho del mundo católico como parte de un discurso legitimador. En la capital novohispana se pintó a inicios del siglo XVII una alegoría al respecto. En este trabajo se abordan los elementos que se representaron en ella para lograr un acercamiento al imaginario carmelitano de su tiempo en donde el discurso que la sustenta fue ideado.
Criteria for evaluating the effectiveness of bentonites in the production of custom castings
Authors: Kulikov S. A. , Rudnitsky F. I. , Shumigay V. A.
Published: December 2023

The article analyzes the characteristics of bentonites used in the foundry industry of the Republic of Belarus. It is concluded that GOST 28177‑89 allows one to effectively assess the quality of bentonites depending on production conditions. It has been shown, that the wet tensile strength is the most important characteristic of bentonites.
Technological basis of processing skarn copper-gold-bearing ores of the Kyrgyz Republic
Authors:   Kyrgyz State Technical University named after I. Razzakov, KOZHONOV Almaz , CHANTURIA Valentin ,   Institute of Comprehensive Exploitation of Mineral Resources Russian Academy of Sciences, NOGAEVA Kulgamal ,   Kyrgyz State Technical University named after I. Razzakov, ALPIEV Yessil ,   Kaz Minerals Bozymchak LLD
Published: December 2023

Introduction. The paper studies the matters of processing of skarn copper-gold ores from a deposit in the Kyrgyz Republic. Materials and methods. As a study task, the authors performed an analysis of the material composition, including micro- and macroscopic types of analyses are presented. Results. Textural-structural analysis and mineralogical characteristics of the main ore minerals is detailed. The characteristic features of the material composition of the studied types of ores are highlighted and described. The reagent suite for processing of skarn ores has been established by means of additional feed of weakly selective depressants (Na2SiO3) and effective flotation reagents to the process, the introduction of which can significantly improve the concentrate quality. The study direction is also supplemented by the consideration and introduction of the process of mechanical activation into the process flow diagram as a reserve in increasing the grade of metals in the concentrate through the mechanical liberation of minerals by ultrafine grinding. The forms of metal loss with concentrating tailings, which are represented by wollastonite, garnet (andradite) and pyroxenes, clay-micaceous minerals, feldspars, and talc are determined. Discussion. The main losses of sulphide copper are associated with the presence of intergrowths of copper minerals with barren minerals in the samples. When evaluating copper minerals in tailings, copper is present in sulphide minerals – 79.2% and 20.8% rel. belongs to the oxide minerals. Conclusion. The paper summarizes the results of the study with the developed closed flotation flowsheet for the processing of copper-gold skarn ores, which makes it possible to obtain the flotation concentrate with grade of Cu – 25.01%, Au – 55.02g/t, Ag – 401g/t, with recovery into concentrate of Cu – 84.65%, Au – 87.94%, Ag – 89.44%. Concentrate output 2.33%. The implementation of the proposed flowsheet will ensure the achievement of planned production performance in the processing of skarn ores. Resume. At the end of the study work, the authors issued recommendations on adjusting the reagent suite with the inclusion of the weakly selective depressant – liquid glass (Na2SiO3), introducing the process of attritioning the feed of the cleaning operation (ultrafine regrinding) and considering the regularity of the phase composition of the copper minerals of skarn ore from the copper grade, providing the initial grade of copper at 0.9-1.0% in the processed ore by blending the ore feed ore to the concentrator. Suggestions for practical application and direction for future research. The materials of the paper can be useful for mining and processing enterprises when processing skarn copper-gold ores.
Maintenance and repair of drum mill trunnions of a floating mining equipment complex
Authors:   Saint-Petersburg Mining University, IVANOV Sergey , KOROGODIN Artur ,   Saint-Petersburg Mining University
Published: December 2023

Introduction. In order to develop promising deposits of non-ferrous metals in the Arctic zone, in particular the Pavlovskoye lead-zinc deposit on Novaya Zemlya, it is necessary to develop climate-saving geo-technologies for mining. In this connection, a concept of conservation geo-technology has been developed and proposed through the use of a specially designed floating complex of mining equipment, included together with the quarry equipment in a single technological chain for the extraction of ore raw materials and its processing into concentrate. However, for the full functioning of the concept of this geo-technology, it is necessary to carry out preventive maintenance and repair of mining equipment at the site of its operation on a floating complex. Research methods and materials. The methodological basis of the work is a systematic approach to the studied means of carrying out repair and restoration works of mining machinery and equipment, which includes both theoretical analysis and generalization of the results of fundamental and applied works of domestic and foreign authors, including methods and theories of designing technology for repairing metalworking and mining processing complexes, multicriteria analysis and simulation modeling. Research results. The article proposes a new technology for the implementation of repair work to restore the working surfaces of hollow loading and unloading support trunnions of hydrostatic sliding bearing units of a drum mill in cramped deck conditions of a floating complex of mining equipment for the development of deposits in the Arctic zone. The structure of the built-in mechanized modular machine tool complex is developed and presented, with the help of which the hollow support trunnions of the drum mill are directly machined according to the patented repair technology. Conclusion. It is shown that the use of the described repair technology by means of an embedded mechanized modular complex will reduce the complexity of the overhaul of the trunnions without the need to perform dismantling work to disconnect the mill drum body from the hollow trunnion caps, which has a positive effect on the accuracy of processing the working surfaces of hollow trunnions.
Downhole Completion Challenges and Solution using Critical Nonmetallic Sealing Technologies
Authors: Asthana Pranay , Larbi Zeghlache Mohamed , Almulhim Marwan , Bukhamseen Ahmed
Published: December 2023

Many of the new completion technologies were introduced to address the challenges related to the increasing well complexity and the advancement in the downhole high-pressure high-temperature (HPHT) realm. This paper focuses on the evolution of Nonmetallic sealing technologies used in downhole completion tools, from the simple O-ring based chevron stacks to the energized hybrid composite seals. Furthermore, future advances in seal development are discussed to tackle the new corrosive challenging environments. A literature review and subject matter expert input were gathered to study the nonmetallic seal design technologies and tool applications. The topics covered include material selection; chemical and environmental resistance; mechanical design and characteristics; durability and abrasion resistance; rigors of verification and life validation testing; challenging corrosive downhole scenarios for seals; and harnessing the environment to create application-specific seals. Various categories of sealing functions are discussed, including tubing/annulus barriers, static/dynamic sealing configurations, and temporary/permanent applications. Sealing technology selection for every downhole tool in the completion string is crucial to ensure safety, reliability, and profitability of a well completion for its planned life. This paper provides a reference with guidelines and best practices for reservoir and production engineers. Often, collaboration projects between operators and service providers can help in developing tailored and advanced Nonmetallic solutions. An understanding of sealing technology will assist in efficient project execution and curated design assurance.
Light Intervention Platform for 28,500-psi Environments
Authors: Rodriguez Rafael , Copold Derek , Milkovisch Mark , Babin Christopher , Ramirez Rafael , Ugah Ibrahim
Published: December 2023

An operator, while designing their completion, needed to secure slim electrical-line intervention technologies, including shifting, debris removal, and milling services. Environmental challenges dictated the following requirements for intervention: 28,5000-psi pressure rating, 150°C temperature, 2.313-in. pass-through restriction, and sour service (H2S rating) as required by the operator.

No slim electrical-line intervention technologies existed that met the sour high-H2S, high-pressure, small pass-through restriction requirements. However, upgrading an existing 20,000-psi slim electrical-line instrumented and automated intervention platform was an economical and technically feasible option that would meet the operator's requirements. The slim high-H2S and high-pressure upgrade was achieved by improving the pressure rating of critical components through a combination of using high-performance materials and optimizing the mechanical robustness by removing high-pressure stress concentrations.

Functional and environmental tests were completed to validate the solution.

This paper presents the analysis and development done to arrive at this solution, demonstrating how a flexible intervention architecture can be upgraded to expand its performance capabilities. The solution also enables future possibilities of expanding the platform to additional services such as tubing cutting and restriction navigation at pressures up to 28,500 psi.
A New GOR Forecasting Methodology for Unconventional Reservoirs
Authors: Chen C. , Lumbangaol A. , Zhou H. , Miocevic D. , McMahan N.
Published: December 2023

The producing GOR trend of unconventional wells is a function of the complex interaction of fluid properties, geology, completion design, well spacing/stacking geometry, and operational changes. These complexities bring as an outcome a wide variation of GOR trends with time. This paper introduces a novel normalized forecasting process to build GOR type curves along with the uncertainty ranges. The long-term GOR range is comparable to theoretical PVT model expectations and offset wells with longer production history. The proposed methodology requires integrated multi-discipline efforts and is not a machine-learning modeling process. Groups of wells are selected based on similar geology and fluid properties while removing wells with poor data quality and operational issues. Next the normalized cumulative oil/EUR is introduced to compare the cumulative GOR curves. Empirical models are then generated to fit the GOR curves and forecast long-term GOR trends. A novel approach for terminal GOR range is applied to constrain the results from empirical models. The normalized process creates proven accurate gas predictions compared to the first three years of well performance. Two different approaches are used to validate the forecasted GOR. The first approach is to derive the terminal GOR range with the available PVT report. The second approach is to benchmark with offset wells with long history. Both approaches show the forecasted GOR is within the reasonable range. The normalized forecasting method has been tested for different areas in Delaware and Midland basins, covering a wide GOR range, and demonstrates its robustness in the forecast.
Barriers and enabling factors to reproductive healthcare utilization for women in the sex trade: a qualitative study
Authors: Birger Lior , Benyamini Yael , Goor Yael , Sahar Zohar , Peled Einat
Published: December 2023

Background: Women in the sex trade encounter significant challenges in obtaining reproductive healthcare. Reports of reproductive healthcare for women in the sex trade center on the prevention and termination of pregnancies, yet most women in the sex trade globally experience full term pregnancies and bear children. This study aimed to explore barriers and enabling factors to providing reproductive healthcare for women in the sex trade in Israel.
Methods: We conducted a qualitative study utilizing a grounded theory method. Data were collected through semi-structured interviews, conducted between June 2021 and July 2022. Interviews were conducted with practitioners in healthcare settings (n=20), practitioners in social services settings (n=15), and women in the sex trade who received reproductive health care-related medical services (n=13) in Israel. The interviews were audiotaped, transcribed, and thematically analyzed.
Results: The findings indicated a multilayered structure of healthcare system-related factors and women-related factors. Stigma was noted as a multidimensional barrier, reflected in service providers' attitude towards women in the sex trade, impairing the patient-provider relationship and impeding women's help-seeking. However, the creation of a relationship of trust between the women and healthcare providers enabled better health outcomes.
Conclusions: Based on the findings, we propose recommendations for designing and implementing reproductive healthcare services for women in the sex trade. The recommendations offer to (a) include women with lived experiences in planning and providing reproductive healthcare services, (b) adopt a trauma-informed approach, (c) emphasize nonjudgmental care, (d) train healthcare providers to reduce stigma and bias, and (e) enhance the affordability of health services for women experiencing marginalization.
Saucer blowouts in the coast dune fields of NW Spain, Iberian Peninsula
Authors: Flor Germán Santos , Martínez Patricio
Published: December 2023

Three selected stabilized saucer blowouts in the coast of NW Spain (Iberian Peninsula) are studied under the morphological and sedimentological points of view. The morphologies of these blowouts are characterized: rim, crest, deflation bottom, right (inner and outer) and left (outer and inner) flanks, outer windward and inner lee ward flanks, inner windward and outer lee ward flanks. They are slightly elongated according to the main direction of the prevailing wind. From surficial sand samples, isolines of grain-size parameters such as centile, mean, sorting, skewness, and kurtosis, as well as the mineralogical composition (bioclastic carbonate versus siliciclastic percents) have been considered to establish specific trends. In many cases, isoline contours are adapted to the floor and the sedimentary rim, allowing to deduce the main flow of the wind that contributes to their formation and development of the complex geometry including their granulometry and composition. The average size is coarser in the outer windward and deflation bottom, and minimum in the crest; the sorting is better in the outer lee side and moderate on the bottom; the skewness shows no contrast being only extreme in the inner lee side; less sharp curves are represented on the windward and leeward flanks and crest, and are leptokurtic on the leeward side; carbonate percents are maximum on the outer lee ward side, followed by the bottom, being minimum on the inner windward side. The flank slopes are very high in the outer leeward and internal windward, and moderate in the outer windward and flat in the crest and deflation bottom. A simple model of morphodynamic and sedimentary characterization is proposed.
Impact of Rapid Urbanization on Aquatic Ecosystem Services: A Case Study of Jiuxianghe Watershed in Nanjing, China
Authors: Chen Dongxiang , Hou Xianrui , Li Xiaotian , Feng Jiawei , Wu Shaohua
Published: December 2023

The urbanization process causes the increase of impervious surface, changes the underlying surface, material and energy cycle, and profoundly affects the urban ecosystem. Based on the hydrological process model, we constructed an evaluation framework for water ecosystem services. Taking the Jiuxiang River basin in Nanjing as an example, this study evaluates the process of urban impervious surface growth and hydrological cycle changes from 2000 to 2015, and reveals the impact of urbanization on water ecosystem services. The results showed that the impervious surface of the Jiuxiang River Basin in Nanjing increased rapidly from 2000 to 2015, and the impervious surface density increased from low to high. In the past 15 years, water supply services in urbanized areas have increased by 23.2%, while water regulation services and supply services have decreased by more than 20%, increasing the risk of urban waterlogging. Rapid urbanization changes the flux and stock in the water cycle process of urban ecosystems, which is the mechanism that leads to the decline of water ecosystem regulation services, support services and cultural services. The evaluation framework and technical method of water ecosystem services proposed in this study can provide theoretical basis and technical reference for water ecosystem services research and urban water ecosystem restoration.
Molecular transmission network analysis of newly diagnosed HIV-1 infections in Nanjing from 2019 to 2021
Authors: Shi Hongjie , Li Xin , Wang Sainan , Dong Xiaoxiao , Qiao Mengkai , Wu Sushu , Wu Rong , Yuan Xin , Wang Jingwen , Xu Yuanyuan , Zhu Zhengping
Published: December 2023

Objective
The objective of this study was to conduct a comprehensive analysis of the molecular transmission networks and transmitted drug resistance (TDR) patterns among individuals newly diagnosed with HIV-1 in Nanjing.
Methods
Plasma samples were collected from newly diagnosed HIV patients in Nanjing between 2019 and 2021. The HIV pol gene was amplified, and the resulting sequences were utilized for determining TDR, identifying viral genotypes, and constructing molecular transmission networks. Logistic regression analyses were employed to investigate the epidemiological characteristics associated with molecular transmission clusters.
Results
A total of 1161 HIV pol sequences were successfully extracted from newly diagnosed individuals, each accompanied by reliable epidemiologic information. The analysis revealed the presence of multiple HIV-1 subtypes, with CRF 07_BC (40.57%) and CRF01_AE (38.42%) being the most prevalent. Additionally, six other subtypes and unique recombinant forms (URFs) were identified. The prevalence of TDR among the newly diagnosed cases was found to be 7.84% during the study period. Employing a genetic distance threshold of 1.50%, the construction of the molecular transmission network resulted in the identification of 137 clusters, encompassing 613 nodes, which accounted for approximately 52.80% of the cases. Multivariate analysis indicated that individuals within these clusters were more likely to be aged 60 years or older, unemployed, possess a baseline CD4 cell count greater than 200 cells/mm3, and infected with the CRF105_0107 subtype (P < 0.05). Furthermore, the analysis of larger clusters revealed that individuals aged 60 years or older, peasants, those without TDR, and individuals infected with the CRF105_0107 subtype were more likely to be part of these clusters.
Conclusions
The findings of this study highlight the elevated risk of transmission and spread of the HIV epidemic associated with the CRF105_0107 subtype in Nanjing. Additionally, the high prevalence of TDR among newly diagnosed individuals is a cause for concern. It is crucial to implement targeted interventions that take into account the molecular transmission clusters identified in this study to effectively control the HIV epidemic in Nanjing. Further research should be conducted to explore and develop specific strategies tailored to address the unique challenges posed by these clusters. By doing so, we can mitigate the impact of HIV and reduce its transmission within the population of Nanjing.
Automatic identification of community-onset sepsis among patients attending an emergency department – a validation study
Authors: Duré Cristian , Jonmarker Sandra , Bohm Katarina , Nordqvist Hampus , Joelsson-Alm Eva , Rimling Liivi , Franko Mikael Andersson , Cronhjort Maria , Ängeby Kristian
Published: December 2023

Purpose To develop and validate a software application able to identify cases of community-onset sepsis based on Sepsis-3 criteria among patients visiting an emergency department.Methods An application, developed with the software QlikView®, accessed data from the electronic health record systems TakeCare® and CliniSoft®. It utilized indicators like blood culture data, antibiotic administration, and Sequential Organ Failure Assessment scores to detect sepsis cases likely to fulfil Sepis-3 criteria. The application was tested retrospectively against a cohort from a large city hospital in Stockholm during a period of two years. The performance of the application was compared to physician record review in a subset of cases identified by stratified random sampling.Results Among 229,195 emergency department visits leading to 60,213 hospital admissions, the application detected 7,027 cases of sepsis. Validation using physician record review of totally 426 cases as gold standard demonstrated a sensitivity, specificity, positive predictive value and negative predictive value of 94%, 98%, 92% and 99%, respectively. The lower respiratory tract was the most common site of infection.Conclusion This software application effectively identified community-onset sepsis patients using electronic health record data with high performance. It has the potential to improve sepsis case identification, enable further research on sepsis incidence and mortality, and support adherence to treatment guidelines as well as contributing to enhanced sepsis surveillance and the implementation of quality improvement interventions.
Using the FIB-4, automatically calculated, followed by the ELF test in second line to screen primary care patients for liver disease
Authors: Ouzan Denis , Penaranda G. , Jlaiel M. , Joly Helene , Corneille Jeremie
Published: December 2023

The objective of our work was to evaluate the screening of hepatic fibrosis in primary care using the FIB-4 score, automatically calculated. When the FIB-4 was ≥ 1.3, it was defined as positive, and ELF Test was performed. FIB-4 positivity was confirmed when ELF Test was ≥ 9.8. Results: Among the 3427 patients included in primary care, 869 (25%) had a positive FIB-4 score, 784 (22.5%) at intermediate (FIB-4: 1.3–2.67), and 85 (2.5%) at high risk of fibrosis (FIB-4 > 2.67). 509 (59%) of the FIB-4 positive were confirmed by the ELF Test. The percentage of confirmation was significantly higher in patients over 65 years (83 vs. 57%), with FIB-4 > 2.67 (80 vs. 56%), BMI > 25 (47 vs. 37%), and diabetes (24 vs. 14%), p = 0.001). In patients without known liver disease (92%), the practitioner identified a cause of disease in 27% of cases: mainly NAFLD and alcohol. Conclusion: Liver fibrosis was suspected on FIB-4 in 25% of patients who consulted a general practitioner. The ELF Test, performed as a second-line, improves the screening of liver fibrosis, particularly for FIB-4 indeterminate results. A positive FIB-4 test allows physicians to recognize a liver disease, providing an opportunity for timely intervention.
Geospatial Discovery of Promising Groundwater Abstraction Zones through Weighted Linear Combination and Probabilistic AHP Approaches
Authors: Dipto Abir Mahmud , Rasel H. M. , Hossain ABM Shafkat , Mamun Abdullah Al , Saki Saleh Ahmad , Ahad S. M. Abdullah Al
Published: December 2023

Global water shortages are getting worse due to the effects resulting from climate change and rising groundwater abstraction. The current study's objective is to evaluate groundwater possibility zones for abstraction (GPZ) in the Dhaka division employing Remote Sensing (RS) and Geographic Information System (GIS) methods. A combination of Linear weight (WLC) along with the Analytical Hierarchy Process (AHP) was employed, integrated with Arc-GIS, to discover Groundwater Possibility Zones for abstraction of a region that spanned from the district's boundaries to 6 kilometers outside. The rate of groundwater abstraction, precipitation, LULC sequence, roughness of the earth's surface, drainage patterning, recuperate stipulation, geomorphology, and the possibility of evapotranspiration (PET) are several variables that affect the area's declining groundwater levels. The settlement area's density of water drainage and penetration region were altered to mitigate the adverse impact on the findings, and seven thematic layers were employed to determine the GPZ for abstraction. The GP estimate found that "shallow" groundwater potential zones covered 6018 km2 (24%) and that "low," "average," "high," and "extremely high" potential zones covered 5143 km2 (19%), 2150 km2, 3138 km2, and 4154 km2 correspondingly. Drainage density was discovered to be the most delicate factor. Based on seven physiographic, geomorphologic, and hydrological characteristics (i.e., precipitation, use of land and vegetation cover, concentration of drainage, contour density, and gradient), both WLC and AHP assessments have been carried out in this instance. The estimated net replenishment quantity for the years 1992 to 2022 was assessed utilizing the concept of the Water Table Fluctuation method.
Navigating daily life with fibromyalgia: Insights from women’s experiences on challenges and coping strategies.
Authors: Sánchez Daniel Sanjuán , Sanz Carolina Climent , Vera Maria del Mar Patiño , Sánchez Montserrat Gea , Carnacea Francesc Rubi , Vozmediano Erica Briones
Published: December 2023

Purpose
Fibromyalgia symptoms can significantly limit a person’s ability to function and participate in daily activities. Exploring patients’ perceptions on the impact of fibromyalgia symptoms on functionality can provide valuable insight on their experiences, coping strategies, needs, and priorities. The aim of this research is to describe the strategies and adaptations used by women with fibromyalgia to carry out basic, instrumental, and advanced activities of daily living.
Methods
Qualitative study based on personal interviews with 25 women diagnosed with fibromyalgia. A thematic analysis was conducted following the classification of activities of daily living into basic (movement and moving around, personal hygiene and getting dressed), instrumental (cleaning, housekeeping, and shopping) and advanced (work).
Results
Participants reported limitations in performing all types of daily activities, including basic (movement and mobility, personal hygiene, dressing), instrumental (cleaning, housekeeping, shopping) and advanced(work-related) activities. To enhance their occupational competence, the identified strategies included energy conservation techniques, balancing activity, and rest, adjusting in the timing and organization of daily activities, delegating tasks, persevering despite pain and fatigue, utilizing technology, and discontinuing certain activities.
Conclusion
Healthcare professionals caring for women with fibromyalgia should recognize the impact of FM on patients’ functionality and employ strategies to improve their adaptation, as well as facilitate the assessment of disability leave.
Demographic predictors of patients’ satisfaction with their recovery after non-catastrophic musculoskeletal injuries: a cross-sectional study
Authors: Maleki Mahshad , Modaressi Shirin , Bakhshi Enayatollah , Hosseini Seyed Ali
Published: December 2023

Background
Orthopedic injuries can significantly negatively influence a patient’s physical and mental health. Achieving patient satisfaction with recovery is essential for reaching patient goals.
Objective
We aimed to investigate whether satisfaction with recovery can be predicted based on demographic information and baseline characteristics in people with non-catastrophic musculoskeletal trauma.
Methods
Participants (n = 100) with acute musculoskeletal injuries were recruited. The Satisfaction and Recovery Index (SRI) was used to assess the patient’s satisfaction with their recovery. A two-tailed Pearson correlation was performed to evaluate the correlation between the SRI scores and continuous variables. One-way ANOVA and independent samples t-test were used to assess whether there were any differences in the SRI scores between ordinal and nominal study variables, respectively. A multivariable linear regression model was created to determine factors independently associated with SRI scores for which all variables with P < 0.10 from the bivariate analysis were included.
Results
There was no association between the SRI scores and age (r = 0.13, P = 0.21), sex (F = 0.94, P = 0.22), educational level (F = 1.07, P = 0.30), number of people living with the patients (r = 0.05, P = 0.60), marital status (F = 0.20, P = 0.87), type of injury (F = 0.53, P = 0.67), injured body part (F = 1.91, P = 0.17), mechanism of injury (F = 0.62, P = 0.60), job(F = 0.47, P = 0.70), time since injury (r = 0.03, P = 0.73).
Conclusions
Demographic variables and baseline characteristics are not associated with the level of satisfaction with recovery among patients with non-catastrophic musculoskeletal trauma. Clinicians can use these findings to rule out these variables as contributors to low (or high) satisfaction with recovery. Future studies must assess the contribution of other probable and relevant psychological and social characteristics.
Genome-wide exploration of metabolic-based pyrethroid resistance mechanism in Helicoverpa armigera
Authors: Kim Juil , Rahman Md-Mafizur , Han Changhee , Jeon Jungwon , Kwon Min , Lee Si Hyeock , Omoto Celso
Published: December 2023

To elucidate the deltamethrin resistance mechanism in Helicoverpa armigera, we explored mutations at the deltamethrin target site, genomic level variations between insecticide-susceptible and -resistant strains, and differences in gene expression patterns between the strains. Known pyrethroid resistance-associated point mutations within the voltage-gated sodium channel were undetected in the cDNA and gDNA of resistant strains or field populations. The whole-genome de novo assembly of a Korean resistant strain was performed (GCA_026262555.1), and 13 genomes of susceptible and resistant individuals were re-sequenced using field populations. Approximately 3,369,837 variants (SNPs and indels) were compared with our reference H. armigera genome, and 1,032,689 variants were identified from open reading frames. A resistance-specific CYP3 subfamily gene with five variants (CYP321A1v1–v5) was identified in the resistant strains, indicating the potential role of these variants in resistance. RNA-seq analysis identified 36,720 transcripts from 45 Illumina RNA-seq datasets of the fat body, gut, and the rest of the body. Differential gene expression analysis revealed some differently overexpressed detoxification enzyme genes in the resistant strains, particularly cytochrome P450 genes. This finding was consistent with the results of bioassay tests using PBO-based synergists, further supporting the role of detoxification enzymes in resistance. Therefore, H. armigera may acquire deltamethrin resistance through a combination of actions, including the overexpression of various detoxification enzymes, such as CYP3 subfamilies (CYP321A5) and cuticular proteins. The five variants of CYP321A subfamily identified in this study may serve as a basis for understanding insecticide resistance at the molecular level and can be applied as diagnostic markers for resistance.
Purse string suture for hemostasis after removal of large-caliber femoral venous delivery sheaths in pediatric transcatheter intervention of atrial septal defect: a single center experience
Authors: Luo Gang , Ji zhixian , Zhang Bei , Ren Yueyi , Pan Silin
Published: December 2023

The objective of this study is to evaluate the efficacy and safety of purse-string suture compared with manual compressing for hemostasis in children with atrial septal defect (ASD) after large-caliber venous delivery sheath removal. We conducted a retrospective study of 271 children with ASD were treated with transcatheter closure of the large-calibe venous delivery sheath (≥ 8 Fr) at our center from January 2018 to January 2023. The control group (n = 127) underwent manual compression for femoral venous hemostasis after removal sheaths. The purse string suture (PSS) group (n = 144) underwent PSS technique. Contrast clinical data on hemostatic time, limb braking time, bed rest time, hospital stay and complications (rebleeding, hematoma formation, local blood ooze, skin ecchymosis and skin damage) between two groups of patients. Compared with the control group, the average hemostatic time (4.63 ± 1.95 vs. 19.69 ± 5.64) min, limb bending time (6.83 ± 2.25 vs. 13.45 ± 2.87) h and bed rest time (8.69 ± 1.43 vs. 22.93 ± 2.24) h were significantly shorter in the PSS group, compared to the control group (P < 0.001). The differences regarding hospital stay and complications between the two groups were statistically insignificant (P༞0.05). Conclusions: The PSS is a straightforward, effective, and secure procedure for attaining rapid hemostasis after removal of large-calibe venous delivery sheath (≥ 8 Fr) for transcatheter closure of ASD in children. The PSS enables pediatric patients to access earlier mobilization and physical activity, a shorter bed rest duration and relief of discomfort when compared to manual compression.
COVID-19 outbreak among employees of a German hospital – risk factor analysis based on a follow-up questionnaire and seroprevalence
Authors: Kosenkow Jennifer , Ankert Juliane , Baier Michael , Kesselmeier Miriam , Pletz Mathias W.
Published: December 2023

The Co-FriSero study (COVID-Friedrichroda seroprevalence study) describes a COVID-19 outbreak in a German hospital with 185 beds (Friedrichroda/Thuringia) and 404 employees at the beginning of the pandemics, which was followed up with a questionnaire and seroprevalence study of the entire hospital staff. Seroprevalence was assessed using two different immunoassays to detect IgG and a third different immunoassay in those with discordant results. Between March 30th 2020 and April 13th 2020, a COVID-19 outbreak occurred within the hospital staff. SARS-CoV-2 infection was confirmed in 25 of 229 employees screened by PCR and in 7 employees by serology only. Employee-reported compliance with wearing personal protective equipment (PPE) differed between those working in the high-risk area (80%) and those in the medium-risk area (72%). Statistical analysis of risk factors revealed an association between SARS-CoV-2 infection and the following potential sources of infection: direct patient contact, exposure to patients with high flow ventilation through unclosed room doors, direct contact with colleagues, lounge, and carpooling among staff. No direct link to infection was represented by contact with family and friends, or public transportation, visiting public events and using health care worker locker rooms. This study underscores that during the early stages of the pandemic, direct patient contact, particularly with ventilated patients through open doors, and inadequate hygiene measures increased the risk for health care workers. Additionally, the study suggests that once introduced, the pathogen can spread outside the hospital setting via staff interactions, emphasizing the need to consider previously overlooked transmission routes, such as carpooling, in future pandemic planning.
Do deep regional trade agreements facilitate regional production networks in Latin American and Caribbean countries?
Authors: Murakami Yoshimichi
Published: December 2023

Using a structural gravity model, this study analyzes the causal effects of the depth of regional trade agreements (RTAs) measured by the coverage and legal enforceability of WTO-plus and WTO-extra policy areas on the production networks trade in all 33 Latin American and Caribbean (LAC) countries from 1990 to 2016. The study constructs a unique dataset on the indexes of the depth, breadth, and core depth of all RTAs in force that include at least two LAC countries, based on a World Bank database on RTAs’ contents. Results indicate that both the depth and breadth of RTAs have positive effects on the intra-regional parts and components exports in the LAC region. However, the effects are substantially heterogeneous by the type of agreements and the characteristics of country-pairs. The depth of custom unions among Latin American countries, mainly the Southern Common Market (MERCOSUR), has positive effects, whereas the depth and breadth of plurilateral free trade agreements with developed countries outside the region (e.g., the United States or European countries) have negative effects. These findings are robust to the use of the mirror import data, the use of three-year interval data, and the inclusion of future values that control for reverse causality.
One is Not Enough: Multi-Agent Conversation Framework Enhances Rare Disease Diagnostic Capabilities of Large Language Models
Authors: Li Jian , Chen Xi , Liu Weizhi , Wang Li , Guo Yingman , You Mingke , Chen Gang , Li Kang
Published: December 2023

Importance
This study adopted multi-agent framework in large language models to enhance diagnosis in complex medical cases, particularly rare diseases, revealing limitation in current training and benchmarking of LLMs in healthcare.
Objective
This study aimed to develop MAC LLMs for medical diagnosis, and compare the knowledge base and diagnostic capabilities of GPT-3.5, GPT-4, and MAC in the context of rare diseases.
Design, Setting and Participants
This study examined 150 rare diseases using clinical case reports published after January 1, 2022, from the Medline database. Each case was curated, and both the initial and complete presentations were extracted to simulate the different stages of patient consultation. A MAC framework was developed. Disease knowledge base was tested using GPT-3.5, GPT-4, and the MAC. Each case was subjected to the three models to generate one most likely diagnosis, several possible diagnoses, and further diagnostic tests. The results were presented for panel discussions with physicians. Disease knowledge was evaluated. The accuracy and scoring of the one most likely diagnosis, several possible diagnoses, and further diagnostic tests were also evaluated.
Main Outcomes And Measures:
Scoring of disease knowledge. Accuracy and scoring of the one most likely diagnosis, several possible diagnoses and further diagnostic tests.
Results
In terms of disease-specific knowledge, GPT-3.5, GPT-4, and MAC scored above 4.5 on average for each aspect. In terms of diagnostic ability, MAC outperformed GPT-3.5 and GPT-4 in initial presentations, achieving higher accuracy in the most likely diagnoses (28%), possible diagnoses (47.3%), and further diagnostic tests (83.3%). GPT-3.5 and GPT-4 exhibited lower accuracy in these areas. In complete presentations, MAC continued to demonstrate higher accuracies in the most likely diagnosis (48.0%) and possible diagnoses (66.7%) compared to GPT-3.5 and GPT-4. Diagnostic capability scoring also indicated higher performance for MAC.
Conclusion And Relevance
Despite the comprehensive knowledge base of GPT-3.5 and GPT-4, a noticeable gap exists in their clinical application for diagnosing rare diseases, underscoring the limitations in the current training and benchmarking methods of LLMs within the healthcare sector. Compared with single-agent models, the MAC framework markedly improves the diagnostic ability of LLMs, enabling more in-depth analysis. Therefore, the MAC framework is a promising tool for the diagnosis of rare diseases in clinical settings and warrants further research to fully explore its potential.
Feasibility of physical function assessment in children with nephrotic syndrome- A preliminary cross-sectional study
Authors: R Lekha , V Hamsa , Alva Rajitha
Published: December 2023

Background
Nephrotic syndrome (NS) is one of the common paediatric renal diseases, primarily managed by steroid therapy. Steroid therapy is associated with significant complications, including reduction in the quality of life in these patients. However, there is lack of evidence addressing the physical function (PF) among children with NS. Therefore, this study aims to assess feasibility of PF evaluation in children with NS and to correlate with the steroid dosage.
Methods
A cross-sectional study included children aged 6 to 12 years diagnosed with NS receiving steroid therapy in the last 6 months. PF assessment included muscle strength (hand-grip strength - HGS), cardio-respiratory endurance (2 Minute Walk Test – 2MWT) and flexibility (Sit and Reach Test - SRT). Descriptive statistics and correlation with the steroid dosage (Mann-Whitney test) were performed using SPSS v.21.
Results
Study included 24 children (50% boys) with a mean age of 8.3years and BMI of (18.16 ± 3.63kg/m²). All three PF components i.e.,2MWT (155.7 ± 38.6m), HGS -boys(9.19 ± 4.08kgs),HGS– girls(8.54 ± 2.32kgs) and SRT(-7.36 ± 4.9cm)exhibited significant reduction in comparison with normative data (p < 0.05, CI 95%). There was no significant correlation between the cumulative steroid dose and PF in the last 6 months.
Conclusion
Children with NS have significant compromise in their physical function compared to normative data. The findings of the study support the need for incorporating routine physical function assessment into the routine standard care protocols in these children.