bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Model Discovery Learning Terhadap Hasil Belajar IPA Siswa Kelas IV SD Negeri 125 Palembang
Authors: Ariasanti Desta , Akhbar M. Taheri , Syaflin Sylvia Lara
Published: June 2022

This study aims to determine whether there is an effect to the discovery learning model on science learning outcomes for fourth-grade students of SD Negeri 125 Palembang. This study uses a quasi-experimental research method (quasi-experimental). The design in this study was a nonrandomized control group pretest-posttest design. The population  is all fourth-grade students of  SD Negeri 125 Palembang. Sampling technique using simple random sampling technique obtained two classes as samples, namely class IV. A as the experimental class and IV. C as control class. The instrument used in the science learning outcomes test for energy source materials is in the form of multiple choice. Testing the data hypothesis in this study using the independent sample t-test. Based on the results of the t-test with tcount = 2,85 while the ttable = 2,011, so the proposed hypothesis can be accepted, namely that there is an influence of discovery learning model on science learning outcomes for fourth grade students of SD Negeri 125 Palembang.
The Implementation Of Interactive Learning Strategy To Formulating Learning Objectives In Package C Program
Authors: Nengsih Yanti Karmila , Handrianto Ciptro , Pernantah Piki Setri , Kenedi Ary Kiswanto , Tannoubi Amayra
Published: June 2022

The implementation of interactive learning strategy in teaching-learning activities may encourage multiple interaction between tutors and learners to achieve their learning objectives. This study aims to identify the effectiveness of interactive learning strategy by tutors to formulate learning objectives among learners in Package C program. The methodology used in this study is quantitative with descriptive approach in analysing the data. There were 30 Package C learners in Binuang Sakti Group in Padang involved with this study. They filled in the questionnaire related to their perception on interactive learning strategy applied by tutors during their study in Package C program. The results of the study show that majority of learners agree that the tutors helped them to formulate learning objectives by implementing interactive learning in their classes. The conclusion of study is that the implementation of interactive learning in Binuang Sakti Group of Package C in Padang is effective to help learners to determine their learning objectives to participate in Package C program.
The Effect of Student-Centered Teaching Methods in Science Laboratories on Academic Achievements of the Students: A Meta-Analysis Study
Authors: BAYSAL Yunus Emre , MUTLU Fatma
Published: June 2022

In this study, it is aimed to synthesize the results obtained from the experimental studies investigating the effect of laboratory-based science education practices on academic achievements of the students in Turkey via meta-analysis method. For this purpose, articles, master's theses and doctoral dissertations having the statistical data that can be included in the meta-analysis study and appropriate to the research problem as a result of the related literature review made on the studies conducted in Turkey between 2013-2018 were analyzed by reviewing in Turkish and English languages from the national and international databases. As a result of the literature review, a total of 34 studies concerning the effect of student-centered teaching methods in science laboratories on academic achievements of the students in laboratory courses and including appropriate data for the coding protocol were included in the meta-analysis. In these individual studies with totally 2237 participants; moderator analyses were performed for the variables of educational level, publication types, teaching methods, science areas and application regions; whereas, meta-regression analyses were performed for the variables of sample size and application durations. It was determined that all the studies included in the study had a positive effect size value. While the effect size calculations of the studies were performed using heterogeneity, publication bias and intervening variable analyses in the “Comprehensive Meta-Analysis Version 2.0” statistical software. A heterogeneous distribution was determined in the studies included (Q=79.41 p<0.05, I2=58.44). Overall effect size value of student-centered teaching methods concerning academic achievements of the students in laboratory courses was found to be d=0.94 (95% CI, SE=0.07) at the confidence interval of 0.80 and 1.09 using random effects model. According to the classification by Cohen, Manion & Morrison (2011), it was determined that laboratory-based learning approach affected academic achievements of the students moderately. As a result of the moderator analyses, it was found that the effect sizes did not vary according to the variables of educational level, teaching methods, publication types, science areas, and application regions.
Trend Analysis of Augmented Reality Studies in Sports Science
Authors: İMAMOĞLU Mehmet , ERBAŞ Çağdaş , DİKMEN Cemal Hakan
Published: June 2022

The purpose of this study was to examine the studies related to augmented reality applications in sports science and to discuss the results based on this. Articles selected for analysis were found through searches journals in the Web of Science database from 1975 to 2018 were examined and searched using the keywords ("physical education" or "physical activity" or "sport$”) and ("augmented reality"). As a result of the search, 44 articles were reached, and 11 articles were excluded from the research because they were not related to augmented reality applications or sports science. The publication classification form consists of the titles "Years, Authors Number, Country, Journals, Age, Sample Size, Variables, Sample Method, Research Method, Data Collection Method and Data Analysis Method." There are a limited number of studies where sports and augmented reality technology are used and interacted together. With the spread of the use of augmented reality and similar technologies in the field of sports sciences, it is thought that such fields as health and education will be positively affected.
Research of consumer preferences for fish culinary products
Authors: Lebedeva Ekaterina Yuryevna , Nevalennaya Anastasia A. , Zolotokopova Svetlana Vasilievna , Mironov Alexander I.
Published: June 2022

The article presents data on studying the consumer preferences for fish culinary products. These data are

of interest to the developers of the new types of fish culinary products. The study was carried out in stages: segmentation of the fish culinary products market, development of a questionnaire and conducting a survey, analysis of the data obtained. The majority of respondents prefer fish culinary products formed from the cutlet mass, fish pies - 14%; fried and baked fish - 12%; steamed fish - 8%; fish dumplings - 5%; fish pastes - 5%; fish sausage and frankfurters - 3%. The majority of respondents (52.5%) are dissatisfied with the assortment, 62% of respondents have a positive attitude about the new types of products entering the market. The most significant characteristics of the quality of fish culinary products in descending order are the following: taste, aroma, texture, nutritional value, lack of intermuscular bones, acceptable price and looking. A relationship between the consumer requirements and the technological characteristics of a new product was built in the form of a quality house.
Influence of digital technologies on modern trends of innovation marketing in communications with consumers
Authors: Shendo Maria Vladimirovna , Sviridova Elena Viktorovna
Published: June 2022

The article focuses on the fact that the rapid development of digital technologies, the emergence of new digital platforms, new functional software allow marketing processes to develop more actively as a field of activity and integrate e-commerce into the lives of customers in accordance with the increased demand for its services. Digital innovations are the basis for the emergence of new services not only for the consumer, but also for the marketing process. Due to digital technologies, many companies have gone far beyond their industry and have become able to meet the needs of customers in a variety of areas, which allowed expanding their target audience and diversify their business. The innovativeness of the promotion itself gives an appropriate result in the presentation of the product on the market and develops innovative marketing at a rapid pace. There have been considered the techniques and technologies of digital marketing used by marketers, shown modern trends in communication with consumers on the digital technology platform. The analysis of the digital advertising market, statistical analysis of Internet users, and also analyzed the position of the Russian Federation in the Global Innovation Index as an indicator of the development

of the innovative component of the country's economy and innovative marketing is made.
El sostenimiento de la vida: Trayectorias de trabajo remunerado y no remunerado de mujeres en México
Authors: Ferraris Sabrina , Martínez Salgado Mario
Published: June 2022

En este artículo analizamos cómo se combinan los tiempos de vida de las mujeres dedicados al trabajo remunerado y no remunerado en México. Asimismo, entendiendo que los cursos de vida son resultado del entrecruzamiento del tiempo histórico y el biográfico, nos interesa plantear las diferencias entre diversas generaciones, así como destacar las desigualdades por origen social y región de socialización. En efecto, siguiendo la perspectiva de la economía feminista, buscamos visibilizar el trabajo doméstico y de cuidados no remunerado que realizan las mujeres como pieza fundamental para el análisis económico y el sostenimiento de la vida. Con este propósito, aplicamos un análisis de secuencias multidimensionales a un conjunto de mujeres entrevistadas en la Encuesta Demográfica Retrospectiva (EDER) 2017, esto para reconstruir una tipología de trayectorias de trabajo que entrelazan las dimensiones remunerada y no remunerada.
O escudo de Aquiles e a tensão entre guerra e mousiké no canto XVIII da Ilíada
Authors: Werner Christian
Published: June 2022

O objetivo deste artigo é discutir como a tensão entre a destruição própria da guerra e a experiência propiciada por atividades musicais ou, mitopoeticamente, da esfera das Musas (mousiké) perpassa o canto XVIII da Ilíada, culminando na narração da forja do novo escudo de Aquiles por Hefesto. As principais passagens discutidas são a reunião das Nereidas como um khóros que participa do lamento de Tétis por Aquiles, a forma como Aquiles conceitualiza seu antigo conjunto de armas e alguns dos aspectos ressaltados no encontro propriamente dito de Tétis e Hefesto. Quanto ao Escudo, além de rastrear-se a tensão entre destruição e mousiké que o perpassa, mostra-se como essa ajuda a esclarecer dois conjuntos de versos problemáticos, 535-38 e 604-5.
Detection of Sub-Surface Defects in Semi-Finished Products from Aluminum Alloys by the Eddy Current Method
Authors: Krysztofik Józef , Malicki Maciej
Published: June 2022

The article presents the results of tests aimed at detecting discontinuities in the subsurface layer of elements intended for further processing. For the initial identification of discontinuities, the method of computed tomography was used. Based on the tomographic images of selected typical defects and measurements of the electrical conductivity of the material, the parameters for the eddy current tests were determined. A series of discontinuities in the subsurface layer to a depth of about 0.48 mm were detected. This allowed, at a given stage of machining, relevant elements to be selected for further processing.
Incorporating User Behaviour Into System Dynamics Modelling: A Case Study of Private vs. Public Transport in Latvia
Authors: Safronova Alina , Barisa Aiga , Kirsanovs Vladimirs
Published: June 2022

In this paper, a newly developed dynamic simulation model for transport user behaviour analysis is presented. The study aims to evaluate the impact of various factors on human behavioural intentions, identify the inconvenience costs of public transport, and identify the necessary improvements to shift the demand for population mobility from private cars to public transport. The assessment of such aspects as travel time and travel cost is presented. Modelling assumptions are based on a specially designed public survey allowing to improve the reliability of the developed system dynamics model. Modelling results highlight the multiplicative effect of factors influencing mode shift.
Animals in the Anthropocene Epoch. On the Importance of Visual Materials in the Pro-Animal Movement
Authors: Sitko Barbara
Published: June 2022

The article aims to discuss the importance of visual materials in the pro-animal movementin terms of their use in various areas of pro-animal activity, i.e. promotion of a plant-based diet orinvestigative activities. The starting point of the considerations is an outline of the issues related toAnthropocene and anthropocentrism (in the context of the current status of animals), and the char-acteristics of pro-animal activities, undertaken mainly by the third sector. Based on the analysis, it hasbeen shown that visual messages perform an important role in shaping convincing messages, andtherefore constitute an invaluable communication tool in the pro-animal movement. They have botha documentary and informative as well as a persuasive character, which is also illustrated by selectedexamples. In addition, the article emphasizes the role of the media in cooperation with the pro-animalmovement, which is an important element of its communication strategy.
Prevalence and pattern of incidental sinus mucosal disease seen on 18F-FDG PET/CT imaging among cancer patients
Authors: Ayesha Aleena , Siddiqui Tariq , Shaukat Ubaira , Fatima Shazia , Saqib Rizwan , Amin Zafar , Sadiq Muhammad
Published: June 2022

Objective: To study the incidental abnormalities of paranasal sinuses in cancer patients who underwent F18- Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) scan.
Subjects and Methods: A total of 342 patients were selected, out of which 101 patients have shown CT findings with F18-FDG avidity in paranasal sinuses. Mucosal thickening, retention cyst, and opacification were seen in one or multiple sinuses bilaterally. Mucosal thickening and opacification were labeled as active disease, while retention cyst as noninflammatory. Maximum standardized uptake values (SUV max) of all the involved sinuses on PET were calculated to assess the correlation between CT and PET findings to derive a cut-off value for sinusitis.
Results: Comparison of mean SUV between mucosal thickening and opacification with that of retention cyst showed significant difference with p-value of sample t-test as 0.001 and best cut-off value for sinusitis to be 1.82.
Conclusion: From the findings of this study, it can be concluded that incidental sinus findings are not seen uncommonly in cancer patients.
A Song for Justice: Collaborative Composition in Response to Brutality
Authors: Middleton Ian
Published: June 2022

This article narrates the collaborative composition of a song in response to the fatal repression of protests in Cali, Colombia, in 2021, It simultaneously provides an analysis of both the final recording and the mediated interactions of the people involved in its creation. I argue that such online musical collaboration can be a fitting response to situations in which direct protest may put participants at risk. The musical sounds of the song, incorporating elements from participatory practices, are not to be understood simply as representing some possible collaborative ethos. Rather, they are direct evidence of the collaboration among participants, as well as solidarity and empathy with those directly involved in protest and the victims of its repression.
De Madeira a Canarias. Fray Gerardo de Abreu (1748-1787...) y los frontales pintados de altar
Authors:   Dirección General de Patrimonio Cultural, Gobierno de Canarias (España), Lorenzo Lima Juan Alejandro
Published: June 2022

In this paper we study the biography of the painter Gerardo Francisco de Abreu (1748-1787...), born in Funchal and resident in Santa Cruz de Tenerife during the 1770s. With these circumstances and his hypothetical profession as a Franciscan friar in 1779, the context that made possible a previous learning is analyzed, as well as the conservative sense of the work that he attended at the end of the 18th century and, specially, the value that he acquires to establish artistic interrelationships between the Atlantic islands, an extensible phenomenon to several painters of the Villavicencio family. From an altarpiece frontal signed and dated in 1787, two more can be attributed to him, preserved in La Orotava and Los Realejos.
La hacienda de Los Príncipes y su ermita (Tacoronte). La imagen de san Juan Bautista: historia y restauración
Authors:   Universidad de La Laguna (España), Marrero Alberto Antonio , Pérez González Lucía Irma
Published: June 2022

The image of San Juan Bautista from the hermitage of the same name in Tacoronte was restored in 2019, revealing the original polychromy that allowed its dating. With this article we address its study while addressing the multiple possibilities that the work of restorers and the analyzes carried out on the piece have for art historians.
El ornato en Canarias 1907-1930. Los arquitectos y el uso de las molduras en las fachadas de Tenerife
Authors:   Universidad de La Laguna (España), Sabina González José Antonio
Published: June 2022

The moldings, which complement the decoration of a building, were represented with an important quality of geometric and organic details, at a time when ornamentation on the facade prevailed. This article will show some, and especially the architects who have included them in their facades will be studied in Tenerife, consulting their plans in the municipal archives between the years 1907 and 1930 in order to obtain results on the particular characteristics of these technicians with respect to these ornaments.
Transcripción de un conjunto documental relativo a la fortificación del lugar y puerto de Santa Cruz de Tenerife entre 1655 y 1657, y relación de la batalla de Santa Cruz de 30 de abril de 1657, por Alonso Dávila y Guzmán
Authors:   Federación Canaria de Actividades Subacuáticas (España), García Montes de Oca Alberto , Rodríguez Illescas José Miguel
Published: June 2022

Many times, we know about events based in indirect and secondary sources, that are studied like original sources. But many times, their content lead to error. In order to get information about an event or historical process, if it is posible, we have to search information sources near to the events, to be able to compare and check them. This is the case of the event of the New Spain Fleet sunk in Santa Cruz de Tenerife and the information about the fortification of the place during the war with England, started in 1655.
Aproximación a las acciones de Terapia Ocupacional en el contexto gubernamental colombiano
Authors: Fonseca Villamarín María Elizabeth , Morera Niño Yenny Marcela
Published: June 2022

La Terapia Ocupacional social y política, en Colombia, es una realidad. Trascender el modelo de atención restaurativo, intramural y basado en el hacer individual, para continuar construyendo identidad profesional sobre contextos sociales cambiantes, permite enriquecer el abordaje de la ocupación humana como determinante histórico que puede condicionar la estructura misma de una sociedad. Las ocupaciones cobran relevancia como determinantes sociales, no solo desde el ámbito sanitario sino en su relación con el bienestar, los derechos y el ejercicio de la ciudadanía de las personas; los indicadores de equidad social; el fomento del capital social y del desarrollo humano. El desarrollo histórico de la Terapia Ocupacional brinda herramientas para comprender y ampliar esta perspectiva emergente y ligarla con una nueva visión donde los fenómenos políticos, sociales, económicos y culturales y sus consecuencias son multicausales y se manifiestan de diversas maneras en las personas, los grupos, los contextos y la ocupación.
Reflexión sobre el hacer del terapeuta ocupacional
Authors: Duarte Torres Sylvia Cristina
Published: June 2022

Este artículo responde a la invitación de la Editora y el Comité Editorial de la Revista Ocupación Humana, para la publicación del número especial de celebración de los 50 años de fundación de la organización científica y gremial de las y los terapeutas ocupacionales de Colombia. Recoge las memorias, análisis y reflexiones a futuro de la terapeuta ocupacional Sylvia Cristina Duarte Torres, quien tuvo a su cargo la presidencia de la Asociación Colombiana de Terapia Ocupacional -ACTO en el periodo 1996 a 1999. Este y los demás textos de expresidentas que hacen parte de este número especial están llenos de la fortaleza, energía y proyección de sus autoras y de nuestra profesión. Resultan, entonces, en un importante y significativo testimonio histórico de lo que hemos construido y de la inmensa y poderosa tarea que tiene el Colegio Colombiano de Terapia Ocupacional para continuar construyendo y respondiendo a los retos del ser ocupacional – personales, colectivos y sociales –, del país, la región y el mundo.
Gestión gremial y descentralización
Authors: Arteta Manrique María Inés
Published: June 2022

Este artículo responde a la invitación de la Editora y el Comité Editorial de la Revista Ocupación Humana, para la publicación del número especial de celebración de los 50 años de fundación de la organización científica y gremial de las y los terapeutas ocupacionales de Colombia. Recoge las memorias, análisis y reflexiones a futuro de la terapeuta ocupacional María Inés Arteta, quien tuvo a su cargo la presidencia de la Asociación Colombiana de Terapia Ocupacional -ACTO en el año 2006. Este y los demás textos de expresidentas que hacen parte de este número especial están llenos de la fortaleza, energía y proyección de sus autoras y de nuestra profesión. Resultan, entonces, en un importante y significativo testimonio histórico de lo que hemos construido y de la inmensa y poderosa tarea que tiene el Colegio Colombiano de Terapia Ocupacional para continuar construyendo y respondiendo a los retos del ser ocupacional – personales, colectivos y sociales –, del país, la región y el mundo.
New records of tropical and subtropical noctuoid moths (Lepidoptera: Erebidae, Nolidae) from Primorsky krai, Russia
Authors:   Institute of Water and Ecology Problems of the Far Eastern Branch of the Russian Academy of Sciences – branch of the Khabarovsk Federal Research Center of the Far Eastern Branch of the Russian Academy of Sciences, Dikopoltsev St., 56, Khabarovsk, 680000, Russia, Koshkin E.S. , Golovizin V.A. ,   Svetlogorskaya St., 35–133, Krasnoyarsk, 660125, Russia
Published: June 2022

Two new Erebidae genera (Hypospila Guenée, 1852 and Lacera Guenée, 1852) and two species, Hypospila bolinoides Guenée, 1852 and Lacera procellosa Butler, 1879, are recorded from Russia for the first time. Siglophora sanguinolenta (Moore, 1888) (Nolidae) is new for the fauna of Primorsky krai. Invasions of tropical and subtropical moths in the southern part of the Russian Far East are briefly discussed.
Evaluation of pollen fertility of sunflower hybrids by the method of split-pollination
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Demurin Ya.N. , Rubanova O.A. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Chebanova Yu.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Kameneva N.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops
Published: June 2022

The main objective of the study was to study the effect of pollen from sunflower hybrids on the real seed productivity and setting of achenes in CMS-tester plants as the final indicators of pollen fertility. The studies were carried out in 2019 and 2021 at V.S. Pusotvoit All-Russian Research Institute of Oil Crops, Krasnodar. The object of the study was cultivated sunflower plants of Helianthus annuus L.: Oksi and NK Brio hybrids as paternal forms, as well as the sterile hybrid Kubansky 93 and the line VK1-klp A as CMS testers. On one vertical part of a separate head, the pollen of the Oksi hybrid was applied, and on the other, the pollen of the NK Brio hybrid was used, i.e. we applied the split-pollination method. The number of fiiled seeds on the head of the CMS tester when pollinated with the pollen of the hybrid Oksi was significantly less than that of the standard hybrid NK Brio. On average, over two years, a decrease in real seed productivity was observed in the hybrid Oksi by 1.97 times in relation to the hybrid NK Brio. The development of a larger number of achenes to technical maturity led to the progressive growth of a part of the head pollinated by the pollen of the NK Brio hybrid. A similar pattern was also noted for the seed set. On the heads of the CMS-tester, on average for two years, the pollen of the hybrid Oksi showed a significant decrease in the setting of achenes in relation to the standard – by 2.24 times. Our earlier data on the presence of morphological anomalies in the pollen of the Oksi sunflower hybrid are consistent with the facts of reduced seed productivity and seed set when evaluating the pollen quality of this hybrid crossed with the CMS-tester, established in this work. The question remains open at what stages the negative impact of the genetic factors of the reproductive function of the pollen of the Oksi hybrid occurs: pre- or post-zygotic.
Evaluation of productivity of oil flax varieties in the conditions of the Sverdlovsk region
Authors:   Ural Federal Agrarian Research Center of the Ural department of RAS, Kolotov A.P. , Kiprushkina N.A. ,   Ural Federal Agrarian Research Center of the Ural department of RAS
Published: June 2022

Oil flax was grown on gray forest soils of the Sverdlovsk region. The purpose of the research was to compare the yield of new varieties of oil flax, to justify the yield value by elements of the yield structure and to determine the seed quality by biochemical composition. The research method was a field experiment with variance analysis of experimental data. We established that in the Sverdlovsk region, even in extreme meteorological conditions, it is possible to obtain the oil flax yield of 1.8–2.2 t/ha. In the ecological trial, the varieties Uralsky, VNIIMK 620 FN, RFN, Fliz, Rachel and Lirina were distinguished by early maturity, in which the growing season was 82 days, which is 10 days shorter than late-maturing varieties. According to the seed yield in the conditions of 2021, the varieties Lirina (2.04 t/ha), Uralsky (1.88 t/ha), VNIIMK 620 FN (1.71 t/ha), Fliz (1.64 t/ha) and Rachel (1.73 t/ha) were distinguished. With small differences between varieties in plant density, the yield value was determined by the optimal combination of the main elements of its structure – the number of pods per 1 plant, seeds in a pod and the thousand-seed weight. The highest yield in the competitive trial was formed by the variety Uralsky yellow (2.28 t/ha). By thousand-seed weight, it is inferior to the variety Northern (standard with brown seeds), but exceeds the similar variety LM 98 with yellow seeds by 1.32 g. In the warm and arid conditions of 2021, flax seeds were characterized by increased oil content. By this trait, the varieties August (48.6%), RFN (46.9%) and Azurite (46.6%) were distinguished.
Large-seeded variety of confectionery sunflower Konditer
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Detsyna A.A. , Khatnyansky V.I. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Illarionova I.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops
Published: June 2022

The large-seeded sunflower variety Konditer was developed at V.S. Pustovoit All-Russian Research Institute of Oil Crops as part of the breeding program for developing varieties of different maturity groups, directions of use and resistance to stressful environment conditions. The variety Konditer belongs to the middle maturity group. The period from seedling to physiological maturity is 96–98 days. Its feature is a potentially high yield, resistance to the complex of broomrape races E, F, G. The plant height is 190–200 cm. The new variety is characterized by high initial growth rate and high germination energy. Thousand-seed weight varies within 100 g at a density of 40 thousand plants/ha, under the recommended density of 25–30 thousand plants/ha, the thousand-seed weight is more than 150 g. Dehulling ability of the variety Konditer is the same as that of the standard variety Dzhinn. The variety Kodniter has been in-cluded in the State Register of Breeding Achieve-ments of the Russian Federation since 2022 and is approved for cultivation in the Central Black Earth (5), North Caucasus (6), Middle Volga (7), and Lower Volga (8) regions.
A cladribina no tratamento da esclerose múltipla: uma revisão integrativa
Authors: La Croix Letícia Maria de Oliveira , Souza Ana Carolina Delecrode de , Pena Victor de Souza , Reis Bruno Cezario Costa
Published: June 2022

Objetivo: Analisar os benefícios para os pacientes com Esclerose Multipla em tratamento com Cladribina Avaliando, assim, a existência de primeira escolha terapêutica com melhores ganhos a longo prazo. Métodos: A abordagem metodológica deste estudo propõe uma compilação bibliográfica de pesquisa qualitativa de caráter descritivo a partir de uma revisão abrangente da literatura utilizando dados National Library of Medicine, Biblioteca Virtual em Saúde e Directory of Open Access Journals. Os descritores utilizados foram “multiple sclerosis”, “cladribine” e “treatment”. Os critérios de inclusão foram artigos de ensaios clínicos, randomizados ou não randomizados, estudos de caso-controle, estudo de coorte, livre acesso, publicados em inglês, português, espanhol e no intervalo de 2017 a 2022. Resultados: Os artigos relatam como principal benefício para o tratamento com a cladribina a redução das recidivas da doença, a redução da linfopenia grave, tolerabilidade, modificador da doença, a redução dos eventos adversos, o controle da atividade grave, as lesões de ressonância magnética e a não alteração a longo prazo na repolarização cardíaca. Considerações finais: Dessa forma, o principal benefício do tratamento da EM com a CB é a redução das recidivas da doença e a redução da linfopenia grave.
Impacto de uma ou mais doenças oportunistas no estado nutricional de pacientes com HIV internados em um hospital universitário
Authors: Miranda Rozinéia de Nazaré Alberto , Machado Paula Mikaelly Pinheiro , Trindade Jacielen Soares , Vieira Cinthia Regina Sales Furtado , Guterres Aldair da Silva , Souza Ranilda Gama de
Published: June 2022

Objetivo: Avaliar o impacto de uma ou mais doenças oportunistas no estado nutricional de pacientes com o Vírus da Imunodeficiência Humana (HIV) internados em um hospital universitário. Métodos: Estudo transversal, prospectivo, realizado em um hospital universitário. Foi aplicado um protocolo de pesquisa objetivando conhecer os dados sociodemográficos, sintomas clínicos, dados antropométricos e presença de doenças oportunistas. Resultados: Na amostra houve prevalência de 56,01% do sexo feminino, sendo 51% na faixa etária de 25 a 39 anos, 70,7% dos pacientes declararam ter um companheiro. Dentre os sintomas clínicos, boca seca obteve maior predominância (56%). A desnutrição se mostrou mais prevalente em todas as variáveis antropométricas, entretanto, ao correlacioná-los com as doenças oportunistas não foi possível observar significância estatística. Quanto às doenças oportunistas, a Tuberculose Pulmonar foi a mais recorrente (32,4%), isoladamente (12,95%) ou associada (19,45%). Conclusão: A maioria dos pacientes apresentou estado nutricional de desnutrição, fato que reforça a necessidade do monitoramento nutricional de forma precoce, visando o restabelecimento do estado nutricional.
Human dental pulp stem cells based therapy for COVID-19
Authors: Saravana Priyan GL
Published: June 2022

The incidence of COVID-19 as a global pandemic led many researchers from various fields to find solutions to manage the spread and treat patients suffering from the disease. This led to the discovery of various vaccines which greatly reduced the spread of COVID-19. However, stem cell therapy was also proposed to be a suitable option in treatment of the same, due to its immunomodulatory properties. There are various ongoing clinical trials with various approaches for the prevention and treatment of COVID-19.
Caspase recruitment domain-containing proteins and dermatoses
Authors: Thanveer Fibin , Ali Lasida
Published: June 2022

The caspase recruitment domain (CARD) is a protein interaction module that comes under the death domain superfamily. CARD mediates important cellular signaling events. Abnormalities in these cellular signaling events play a role in the pathogenesis of malignancies and immune disorders. The significance of CARD in dermatological diseases is less discussed. Mutations affecting CARD-containing proteins are reported to play a pathogenic role in certain patients with dermatoses such as psoriasis, pityriasis rubra pilaris, atopic dermatitis, and fungal infections. These underlying mutations are suggested to have therapeutic implications in various dermatoses, though more information is needed regarding this. This review discusses the association between dermatoses and mutations involving CARD-containing proteins.
Polarizable force field for acetonitrile based on the single-center multipole expansion
Authors: Myneni Hemanadhan , Örn Jónsson Elvar , Jónsson Hannes , Ougaard Dohn Asmus
Published: June 2022

A polarizable potential function describing the interaction between acetonitrile molecules is introduced. The molecules are described as rigid and linear with three mass sites corresponding to the CH3 group (methyl, Me), the central carbon atom (C), and the nitrogen atom (N). The electrostatic interaction is represented using a single center multipole expansion (SCME) as has been done previously for H2O [Wikfeldt et al., Phys. Chem. Chem. Phys. 15, 16542 (2013)], by including multipole moments from dipole up to and including hexadecapole, as well as anisotropic dipole-dipole, dipole-quadrupole and quadrupole-quadrupole polarizability tensors. The model is free of point charges. The non-electrostatic part is described in a pair-wise fashion by a Born-Mayer repulsion and damped dispersion attraction. The potential function is parameterized to fit the interaction energy of small (CH3CN)n, n=2-6, clusters calculated using the PBE0 hybrid functional with an additional many-body dispersion contribution. The parameterized potential function is found to compare well with results of the electronic structure calculations of dissociation curves for different dimer orientations and cohesive properties (the equilibrium volume, cohesive energy, and the bulk modulus) of the α-phase of acetonitrile crystal. The average value of the molecular dipole moment obtained in the α-phase is 5.53 D, corresponding to a ca. 40% increase as compared to the dipole moment of an isolated acetonitrile molecule, 3.92 D.
An Actionable Annotation Scoring Framework for Gas Chromatography - High Resolution Mass Spectrometry (GCHRMS)
Authors: Koelmel Jeremy , Xie Hongyu , Price Elliott , Lin Elizabeth , Manz Katherine , Stelben Paul , Paige Matthew , Papazian Stefano , Okeme Joseph , Jones Dean , Bowden John , Barupal Dinesh , Rostkowski Pawel , Pennell Kurt , Nikiforov Vladimir , Wang Thanh , Hu Xin , Lai Yunjia , Miller Gary , Walker Doug , Martin Jon , Pollitt Krystal
Published: June 2022

Omics-based technologies have enabled comprehensive characterization of our exposure to environmental chemicals (exposome) as well as assessment of the corresponding biological responses at the molecular level (e.g., metabolome, lipidome, proteome, and genome). By systematically measuring personal exposures and linking these stimuli to biological perturbations, researchers can determine specific chemical exposures of concern, identify mechanisms and biomarkers of toxicity, and design interventions to reduce exposures. However, further advancement of metabolomics and exposomics approaches is limited by a lack of standardization and approaches for assigning confidence to chemical annotations. While a wealth of chemical data is generated by gas chromatography high-resolution mass spectrometry (GC-HRMS), incorporating GC-HRMS data into an annotation framework, and communicating confidence in these assignments is challenging. It is essential to be able to compare chemical data for exposomics studies across platforms to build upon prior knowledge and advance the technology. Here we discuss the major pieces of evidence provided by common GC-HRMS workflows, including retention time and retention index, electron ionization, positive chemical ionization, electron capture negative ionization, and atmospheric pressure chemical ionization spectral matching, molecular ion, accurate mass, isotopic patterns, database occurrence, and occurrence in blanks. We then provide a qualitative framework for incorporating these various lines of evidence for communicating confidence in GC-HRMS data by adapting the Schymanski scoring schema developed for reporting confidence levels by liquid chromatography high-resolution mass spectrometry (LC-HRMS). Validation of our framework is presented using standards spiked in plasma, and confident annotations in outdoor and indoor air samples, showing a false positive rate of 12% for suspect screening for chemical identifications assigned as Level 2 (when structurally similar isomers are not considered false positives). This framework is easily adaptable to various workflows and provides a concise means to communicate confidence in annotations. Further validation, refinements, and adoption of this framework will ideally lead to harmonization across the field, helping to improve the quality and interpretability of compound annotations obtained in GC-HRMS.
Binding Modes of Cysteamine Homologues Control Fe(III)–Thiolate Autoredox Rates in a Thiol Dioxygenase Model Complex
Authors: Ekanger Levi A. , Shah Ruhi K. , Porowski Matthew E. , Ziolkowski Zach , Calello Alana
Published: June 2022

Thiol dioxygenases transform thiols to sulfinates facilitating cysteine homeostasis and biosynthetic pathways. Substrate binding modes at thiol dioxygenase active sites have received increasing attention to better understand how selectivity and activation is achieved. Of particular interest is the substrate-binding mode within cysteamine dioxygenase (ADO) because of its unique selectivity for both cysteamine and N-terminal cysteine residues. ADO also exhibits unique reactivity with both substrates through an autoredox reaction of the form ADO-Fe(III)-SR → ADO-Fe(II) + ½ RSSR which is proposed to maintain Fe(II) under oxidative stress conditions. Here we use the thiol dioxygenase model complex [Fe(tacn)Cl3] (tacn = 1,4,7-triazacyclononane) to replicate the 3N facial coordination environment in ADO-Fe(III) and to enable experiments buffered near neutral pH. Autoredox reactions are initiated by forming Fe(III)–thiolate intermediates in situ using cysteamine and cysteamine homologues penicillamine, mercaptopropionic acid, cysteine, N-acetylcysteine, and N-acetylcysteine methyl ester. We observe trends in autoredox rate constants as a function of substrate binding mode. Moreover, we observe autoredox reactivity on the same timescale reported for ADO autoredox activity. To provide evidence of tridentate coordination in the relatively reactive cysteine intermediate, we isolated a stable penicillamine-containing intermediate and characterized its coordination environment and electronic structure using FT-IR, NMR, and magnetic susceptibility measurements.
Una visión del futuro de la energía en el Perú
Authors: Fernández Baca Marco
Published: June 2022

No presenta resumen.
La evaluación del impacto ambiental como un componente de los proyectos de desarrollo
Authors: Olarte Navarro Bertha
Published: June 2022

No presenta resumen.
Áreas naturales protegidas, conservación y desarrollo sostenible
Authors: Jarufe Zedán Benjamín
Published: June 2022

Difundimos aqui el Marco Conceptual utilizado por el Equipo Técnico del Plan Director  en la elaboración de la "Estrategia del Sistema Nacional  de Áreas Naturales  Protegidas  del Perú"
Sistemas de inventarios a punto de pedido (aplicación práctica)
Authors: De Olazábal Tejada Ernesto
Published: June 2022

Es pertinente recordar que es función del ingeniero industrial la determinación y mantenimiento de los niveles deseados de inventario de las materias primas, productos en proceso o productos terminados mediante la aplicación eficaz en este caso de la técnica del lote económico para conseguir que la función de producción no sea obstaculizada por falta de los "artículos" requeridos.
Ichthyosis Uterus – A Rare Premalignant Lesion of Endometrium
Authors: Sai Supriya Muthyala  , Niruby Rasendrakumar  , Nidhi Sharma
Published: June 2022

Ichthyosis (ikTHeosis) uterus is a rare  benign metaplastic transformation  of uterine endometrium into stratified squamous epithelium. The word ichthyosis (plural ichthyoses) comes from two ancient Greek (ixtus), meaning fish and disease. The metaplastic epithelium is parakeratotic with absent granular layer. Premalignant potential of this benign transformation has not been established due to the rarity of occurrence. We report a case of 72 year old female, post menopausal with the complaints of painless lower abdominal distension for past six months. She had no history of menorrhagia or dysmenorrhea in her previous menstrual cycles. USG abdomen was done. She was taken up for elective hysterectomy with a diagnosis of hydrometra. Total abdominal hysterectomy with bilateral salpingo-oophorectomy with pelvic lymph node sampling done. Peritoneal fluid cytology, peritoneal biopsy was done. Gross section of specimen was seen and the same sent for histopathological examination. Based on these histological findings a diagnosis of Ichthyosis uteri with focal High grade Squamous intraepithelial lesion of endometrium was made. In our case, there is a direct continuity of the squamous metaplasia of the endocervix and the endometrial lining. This supports the benign metaplastic spread of squamous epithelium from the transformation zone of the cervix into the uterine cavity. However, the stimulation of squamous metaplasia in uterine endometrium as a result of long term hydrometra is being hypothesised in our patient. The association of hydrometra, squamous metaplasia and dysplastic changes in endometrium are speculated.
POST-SEKÜLERİZM TARTIŞMALARI: YENİ OLAN NE?
Authors: ÇOKOĞULLAR BOZASLAN Emel
Published: June 2022

Genel olarak 1980’lerin ikinci yarısından itibaren kamusal alanda dini canlanma olarak adlandırılabilecek örgütlenmelere ve aktörlere rastlanmaktadır. Kamusal alanın laik sınırlarının bu örgütlenmeler ve aktörler tarafından zorlandığı ve yine bu örgütlenmelerin ve aktörlerin kamusal alanda kendilerine yer bulma çabasının belirginlik kazandığı öne sürülmektedir. Dinin geri dönüşü ya da dini uyanış olarak adlandırılan ve aslında özellikle Batı’da bu hareketliliğin anlamlandırılamadığı bir süreç yaşanmaktadır. “Post-sekülerizm” olarak tanımlanmaya başlayan bu süreç, dinin kamusal alanı oluşturan “çok”lardan biri olup olamayacağı sorusuna odaklanmaktadır. Dinin, bir “müzakere alanı” olarak kamusal alanın dili ve ruhu ile uyum sağlayıp sağlayamayacağı post-sekülerizm tartışmalarının ana konusunu oluşturmaktadır. Başka bir ifadeyle, dinin tek bir hakikat vurgusu ile rasyonel iletişim pratiği açısından ne tür bir meşruiyet zemini oluşturacağı sorunsalı üzerinde durulmaktadır. Sekülerleşme kuramlarının da bu dini canlanma nedeniyle sorgulanmaya başlandığı görülmektedir. Dinin bir daha geri dönmemek üzere modern yaşamın dışına gönderildiği savunusunun aksi yönünde bir gelişme yaşandığı pek çok araştırmacı tarafından dile getirilmekte ve pratiğe yansımaları incelenmektedir. Din, neden geri dönmüştür ya da hiç gitmemiş midir yoksa sekülerliğin yeni bir evresi mi yaşanmaktadır soruları sorulmakta ve bu soruların yanıtları aranmaktadır. Bu çalışmada da literatürdeki bu tartışmaların yanında sekülerleşme kuramlarının neler söyledikleri ve sekülerleşme kuramlarına karşıtlık oluşturacak bir eylemsellikten bahsedilip bahsedilemeyeceği ele alınmaktadır. Batı’daki ve Türkiye’deki dini hareketliliklerin talepleri, görünürlükleri ve kamusalın inşasına dair söylemleri de literatürdeki sorular ve tartışmalar eşliğinde yeniden değerlendirilmektedir.
ÖĞRETMEN ADAYLARININ ÖĞRETİM YETERLİK İNANÇLARININ İNCELENMESİ: ÇOK DEĞİŞKENLİ VARYANS ANALİZİ
Authors: KIZILTEPE İbrahim Serdar , KARTAL Tezcan
Published: June 2022

Öğretim yeterliği, öğretmenlerin öğretim hakkında ne düşündüklerini, kendilerini nasıl motive ettiklerini ve sınıfta nasıl davrandıklarını etkiler. Fen öğretimi bağlamında yeterlik inancının iki boyutu vardır: kişisel fen öğretimi özyeterliği ve fen öğretimi sonuç beklentisidir. Bu çerçevede öğretmen adaylarının fen öğretimi öz yeterliği ve sonuç beklentisi inançlarının incelenmesi amaçlanmıştır. Araştırmada betimsel araştırma desenlerinden kesitsel tarama modeli kullanılmıştır. Araştırma örneklemi Orta Anadolu bölgesinde öğrenim görmekte olan ve lisans dönemi boyunca en az bir defa fen bilimleri dersi almış öğretmen adayları arasından rastgele seçilmiştir. Verilerin elde edilmesinde kişisel bilgi formu ve fen öğretimi yeterlik inanç ölçeği kullanılmıştır. Öğretmen adaylarının fen öğretimi öz yeterlik ve fen öğretimi sonuç beklentisi inançları üzerinde bağımsız değişkenlerin (öğrenim görülen bölüm, cinsiyet ve sınıf düzeyi) etkisi ayrı ayrı ve birlikte çift yönlü MANOVA testi ile incelenmiştir. Öğretmen adaylarının fen öğretimi öz yeterlik ve fen öğretimi sonuç beklentisi inançları öğrenim gördükleri bölüme göre farklılaşmaktadır. Sınıf düzeylerine göre öğretmen adaylarının fen öğretiminde sonuç beklentilerinde son sınıf öğretmen adayları lehine farklılık göstermiştir. Fakat fen öğretimi özyeterlik inançlarında farklılık görülmemiştir. Öğretmen adaylarının fen öğretimi yeterlik inançlarının desteklenmesi için fen ve öğretimine yönelik derslerin sayısı arttırılabilir. Öğretmen eğitim programlarında önemli miktarda alan bilgisi ile mesleki deneyimlerine daha fazla vurgu yapılması fen eğitiminin kalitesini arttırabilir.
TÜRKÇE ÖĞRETMENİ ADAYLARININ HAZIRLIKSIZ KONUŞMAYA YÖNELİK METAFORİK ALGILARI VE GÖRÜŞLERİ
Authors: KURUDAYIOĞLU Mehmet , KİRAZ Büşra
Published: June 2022

Bu çalışmanın amacı Türkçe öğretmeni adaylarının hazırlıksız konuşmaya yönelik algılarını metaforlar aracılığıyla tespit etmektir. Olgubilim (fenomenoloji) yöntemiyle gerçekleştirilen çalışmada öğretmen adaylarının algılarını tespit etmek amacıyla araştırmacılar tarafından Hazırlıksız Konuşma Görüş Formu geliştirilmiş, formla ilgili alanın üç uzmanından görüşler alınmış ve forma son şekli verilmiştir. Çalışmanın örneklemi uygun örnekleme yöntemiyle oluşturulmuştur. Çalışmaya Hacettepe Üniversitesi, Gazi Üniversitesi ve Ondokuz Mayıs Üniversitesi’nde öğrenim görmüş ve görmekte olan 30 öğretmen adayı gönüllü olarak katılmıştır. Çalışmanın verileri anket yöntemiyle toplanmış, toplanan veriler içerik analizi yöntemiyle analiz edilmiştir. Çalışmanın sonucunda öğretmen adaylarının %50’sinin hazırlıksız konuşmayla ilgili kaygı yansıtan metaforlar ürettikleri tespit edilmiştir. Formda yer alan diğer maddeler katılımcıların hazırlıksız konuşmaya yönelik hissettikleri duyguların sebeplerinin anlaşılması amacıyla analiz edilmiştir. Katılımcıların kaygı duymalarının sebeplerinin konuşma planlayamama, düşünceleri organize edememe ve konuşma sürecini kontrol altında tutamama olduğu tespit edilmiştir. Öğretmen adaylarının hazırlıksız konuşmanın pedagojik öneminin farkında oldukları ve kendi öğrencilerine hazırlıksız konuşma öğretimi verme konusunda istekli oldukları anlaşılmıştır. Çalışmanın sonunda konuşma eğitimi sürecine yönelik birtakım önerilerde bulunulmuştur.