bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunogenic cell death-associated biomarkers classification predicts prognosis and immunotherapy efficacy in pancreatic ductal adenocarcinoma
Authors: Peng Wenguang , Yang Jiarui , Xia Long , Qian Xiangjun , Long Guojie , Zhang Hao , Xie Jiancong , Zhao Junzhang , Zhang Lei , Pan Weidong
Published: March 2023

Introduction

Immunogenic cell death (ICD) is a sort of regulated cell death (RCD) sufficient to trigger an adaptive immunological response. According to the current findings, ICD has the capacity to alter the tumor immune microenvironment by generating danger signals or damage-associated molecular patterns (DAMPs), which may contribute in immunotherapy. It would be beneficial to develop ICD-related biomarkers that classify individuals depending on how well they respond to ICD immunotherapy.

Methods and results

We used consensus clustering to identify two ICD-related groupings. The ICD-high subtype was associated with favorable clinical outcomes, significant immune cell infiltration, and powerful immune response signaling activity. In addition, we developed and validated an ICD-related prognostic model for PDAC survival based on the tumor immune microenvironment. We also collected clinical and pathological data from 48 patients with PDAC, and patients with high EIF2A expression had a poor prognosis. Finally, based on ICD signatures, we developed a novel PDAC categorization method. This categorization had significant clinical implications for determining prognosis and immunotherapy.

Conclusion

Our work emphasizes the connections between ICD subtype variations and alterations in the immune tumor microenvironment in PDAC. These findings may help the immune therapy-based therapies for patients with PDAC. We also created and validated an ICD-related prognostic signature, which had a substantial impact on estimating patients' overall survival times (OS).
The potential of COPCA's coaching for families with infants with special needs in low- and middle-income countries
Authors: Akhbari Ziegler Schirin , de Souza Morais Rosane Luzia , Magalhães Lívia , Hadders-Algra Mijna
Published: March 2023

Infants at high biological risk of or with a neurodevelopmental disorder run a high risk of delayed school readiness. This is especially true for infants in low- and middle-income countries (LMICs). This perspective paper first summarizes evidence on intervention elements that are effective in promoting family well-being and child development in infants at high biological risk in high income countries. Crucial elements are family centeredness, goal orientation, a home setting, focus on activity and participation, and challenging the infant to explore the world and the own body by means of self-produced movements. The studies revealed that coaching as applied in COPCA (COPing and CAring for infants with special needs) is a pivotal element determining the success of intervention.The paper continues by describing COPCA and its coaching. Next, we report on two pilot studies addressing COPCA's implementation in Brazil. Finally, we discuss why COPCA is a promising early intervention program for infants at high biological risk of neurodisability in LMICs: COPCA is adapted to the families' strengths and needs, it empowers families and promotes child development therewith facilitating school readiness. Moreover, it may be delivered by tele-coaching therewith eliminating families' burden to travel to distant intervention clinics.
The roles of protocadherin-7 in colorectal cancer cells on cell proliferation and its chemoresistance
Authors: Zheng Zhibao , Luan Na , Tu Kai , Liu Feiyan , Wang Jianwei , Sun Jianguo
Published: March 2023

Despite the high mutation frequencies of KRAS, NRAS, and BRAF in colorectal cancer (CRC), there are no effective and reliable inhibitors for these biomarkers. Protocadherin-7 (PCDH7) is regarded as a potentially targetable surface molecule in cancer cells and plays an important role in their proliferation, metastasis, and drug resistance. However, the roles and underlying mechanisms of PCDH7 in CRC remain unclear. In the current study, we found that different colorectal cancer cells expressed PCDH7 over a wide range. The levels of PCDH7 expression were positively associated with cell proliferation and drug resistance in CRC cells but negatively correlated with the potential for cell migration and invasion. Our data indicated that PCDH7 mediated the resistance of CRC cells to ABT-263 (a small-molecule Bcl-2 inhibitor that induces apoptosis) by inhibiting cell apoptosis, which was supported by the downregulation of caspase-3, caspase-9, and PARP cleavage. We found that PCDH7 effectively promoted Mcl-1 expression at both mRNA and protein levels. Furthermore, PCDH7 activated the Wnt signaling pathway, which was confirmed by the increase in β-catenin and c-Myc expression. Finally, and notably, S63845, a novel Mcl-1 inhibitor, not only effectively attenuated the inhibitory effect of PCDH7 on cell apoptosis induced by ABT-263 in vitro but also sensitized PCDH7-overexpressed CRC cell-derived xenografts to ABT-263 in vivo. Taken together, although PCDH7 inhibited the migration and invasion of CRC cells, it could facilitate the development of drug resistance in colorectal cancer cells by positively modulating Mcl-1 expression. The application of the Mcl-1 inhibitor S63845 could be a potential strategy for CRC chemotherapy, especially in CRC with high levels of PCDH7.
Baicalein-corrected gut microbiota may underlie the amelioration of memory and cognitive deficits in APP/PS1 mice
Authors: Shi Jing , Chen Jie , Xie Xinyun , Li Yuanyuan , Ye Wenjing , Yao Jianbiao , Zhang Xiangnan , Zhang Tianyuan , Gao Jianqing
Published: March 2023

Background: Baicalein is an active ingredient extracted from the root of S. baicalensis Georgi, which exhibits cardiovascular protection, anti-inflammatory, and anti-microbial properties. Our previous study showed that chronic treatment of Baicalein ameliorated cognitive dysfunction in a mouse model of Alzheimer's disease (AD). However, it remains unknown whether Baicalein ameliorates cognitive deficits in AD mouse models by altering gut microbiota and its metabolites.

Methods: Behavioral tests, metagenomic and untargeted metabolomics analyses were used to evaluate the effects of Baicalein on the APP/PS1 mice.

Results: Our research showed that treatment of Baicalein for 2 weeks ameliorated cognition and memory in a dose-dependent manner, as indicated by the significant increases in the Discrimination index and Number of crossings and decrease in latency to the previous platform location in 8-month of age APP/PS1 mice in novel object recognition and water maze tests. The metagenomic analysis showed the abundance of the dominant phyla in all groups, including Bacteroidetes (14.59%–67.02%) and Firmicutes (20.19%–61.39%). LEfSe analysis of metagenomics identified three species such as s__Roseburia_sp_1XD42_69, s__Muribaculaceae_bacterium_Isolate_104_HZI, s__Muribaculaceae_bacterium_Isolate_110_HZI as Baicalein-treated potential biomarkers. Metabolite analysis revealed the increment of metabolites, including glutamate, thymine and hexanoyl-CoA.

Conclusion: The effects of Baicalein on memory and cognition may relate to the metabolism of nucleotides, lipids and glucose.
Effect of traditional Chinese medicine monomers interfering with quorum-sensing on virulence factors of extensively drug-resistant Acinetobacter baumannii
Authors: Zeng Li , Lin Fei , Ling Baodong
Published: March 2023

The antimicrobial resistance of Acinetobacter baumannii (A. baumannii) clinical isolates has emerged as a great threat to public health. Quorum sensing (QS) is one of the resistance mechanisms for drug-resistant A. baumannii. Interfering with QS is a promising strategy to combat infections caused by drug-resistant bacteria. This study explored the QS inhibition ability of thirty-four traditional Chinese medicine monomers (TCMMs) and assessed the effect of QS inhibitors (QSIs) on the virulence factors of twelve extensively drug-resistant A. baumannii (XDRAB) strains. Nine traditional Chinese medicine monomers, such as caffeic acid, cinnamic acid, and myricetin, were found to be able to inhibit the bacterial QS. Then, at 1/8 of the minimal inhibitory concentration, we found that these QSIs inhibited extensively drug-resistant A. baumannii adhesion and biofilm formation and downregulated the expression levels of virulence-associated genes (abaI, abaR, csuE, pgaA, and bap). In conclusion, nine traditional Chinese medicine monomers have QS inhibitory activity and may downregulate QS genes to interfere with the QS system, which could inhibit the expression of extensively drug-resistant A. baumannii virulence factors. These results suggest that traditional Chinese medicine monomers could develop as novel anti-virulence compounds to control extensively drug-resistant A. baumannii infections.
Combined angiotensin-converting enzyme and aminopeptidase inhibition for treatment of experimental ventilator-induced lung injury in mice
Authors: Mao Xinjun , Tretter Verena , Zhu Yi , Kraft Felix , Vigl Benjamin , Poglitsch Marko , Ullrich Roman , Abraham Dietmar , Krenn Katharina
Published: March 2023

Introduction: Ventilator-induced lung injury (VILI) may aggravate critical illness. Although angiotensin-converting enzyme (ACE) inhibition has beneficial effects in ventilator-induced lung injury, its clinical application is impeded by concomitant hypotension. We hypothesized that the aminopeptidase inhibitor ALT-00 may oppose the hypotension induced by an angiotensin-converting enzyme inhibitor, and that this combination would activate the alternative renin-angiotensin system (RAS) axis to counteract ventilator-induced lung injury.

Methods: In separate experiments, C57BL/6 mice were mechanically ventilated with low (LVT, 6 mL/kg) and high tidal volumes (HVT, 30 mL/kg) for 4 h or remained unventilated (sham). High tidal volume-ventilated mice were treated with lisinopril (0.15 μg/kg/min) ± ALT-00 at 2.7, 10 or 100 μg/kg/min. Blood pressure was recorded at baseline and after 4 h. Lung histology was evaluated for ventilator-induced lung injury and the angiotensin (Ang) metabolite profile in plasma (equilibrium levels of Ang I, Ang II, Ang III, Ang IV, Ang 1-7, and Ang 1-5) was measured with liquid chromatography tandem mass spectrometry at the end of the experiment. Angiotensin concentration-based markers for renin, angiotensin-converting enzyme and alternative renin-angiotensin system activities were calculated.

Results: High tidal volume-ventilated mice treated with lisinopril showed a significant drop in the mean arterial pressure at 4 h compared to baseline, which was prevented by adding ALT-00 at 10 and 100 μg/kg/min. Ang I, Ang II and Ang 1-7 plasma equilibrium levels were elevated in the high tidal volumes group versus the sham group. Lisinopril reduced Ang II and slightly increased Ang I and Ang 1-7 levels versus the untreated high tidal volumes group. Adding ALT-00 at 10 and 100 μg/kg/min increased Ang I and Ang 1-7 levels versus the high tidal volume group, and partly prevented the downregulation of Ang II levels caused by lisinopril. The histological lung injury score was higher in the high tidal volume group versus the sham and low tidal volume groups, and was attenuated by lisinopril ± ALT-00 at all dose levels.

Conclusion: Combined angiotensin-converting enzyme plus aminopeptidase inhibition prevented systemic hypotension and maintained the protective effect of lisinopril. In this study, a combination of lisinopril and ALT-00 at 10 μg/kg/min appeared to be the optimal approach, which may represent a promising strategy to counteract ventilator-induced lung injury that merits further exploration.
Effects of chlorantraniliprole on the life history traits of fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae)
Authors: Hasnain Ali , Zhang Shuirong , Chen Qinghua , Xia Lijuan , Wu Yutong , Gong Changwei , Liu Xuemei , Jian Pu , Zhang Lei , Wang Xuegui
Published: March 2023

Introduction:Spodoptera frugiperda is an important nomadic agricultural pest with a diverse host range and resistance against several insecticides. The current study investigated the life history traits of two strains of the field-collected population against chlorantraniliprole using an age-stage two-sex life table.

Method: For this, we established the chlorantraniliprole-susceptible (Crp-SUS G12), and chlorantraniliprole-reduced susceptible (Crp-RES G12) strains derived from the sixth generation of the QJ-20 population having a resistance ratio (RR) of 10.39-fold, compared with the reported susceptible population.

Results: The results showed that the chlorantraniliprole-reduced susceptible strain attained a 4.0-fold RR, while the chlorantraniliprole-susceptible strain attained an RR of 0.85-fold, having overlapped fiducial limits (FLs) with the referred susceptible baseline. Meanwhile, the present study revealed that the development time of the susceptible strain was significantly longer than that of the reduced susceptible strain. Similarly, the mean longevity, adult pre-oviposition period (APOP), and total pre-oviposition period (TPOP) of the female chlorantraniliprole-susceptible strain were considerably longer than those of the female chlorantraniliprole-reduced susceptible strain. Contrarily, the population parameters, including the intrinsic rate of increase (r), finite rate of increase (λ), and net reproductive rate (R), of the chlorantraniliprole-susceptible strain were considerably lower than those of the chlorantraniliprole-reduced susceptible strain, while the mean generation time (T) of the chlorantraniliprole-susceptible strain was substantially longer than the chlorantraniliprole-reduced susceptible strain. The age-stage characteristic survival rate (sxj) and age-stage characteristic life expectancy (exj) of the chlorantraniliprole-susceptible strain were longer than those of the chlorantraniliprole-reduced susceptible strain, but the age-stage-specific reproductive value (vxj) of the chlorantraniliprole-susceptible strain was shorter than that of the chlorantraniliprole-reduced susceptible strain. Moreover, the contents of vitellogenin (Vg) and VgR in the chlorantraniliprole-reduced susceptible strain were higher than those in the chlorantraniliprole-susceptible strain.

Discussion: These findings showed that reducing susceptibility to chlorantraniliprole promoted population growth in S. frugiperda. Therefore, this study could provide conceptual support for the integrated pest management (IPM) approach to control S. frugiperda in the field.
Microalgae as next generation plant growth additives: Functions, applications, challenges and circular bioeconomy based solutions
Authors: Parmar Priyanka , Kumar Raman , Neha Yograj , Srivatsan Vidyashankar
Published: March 2023

Sustainable agriculture practices involve the application of environment-friendly plant growth promoters and additives that do not negatively impact the health of the ecosystem. Stringent regulatory frameworks restricting the use of synthetic agrochemicals and the increase in demand for organically grown crops have paved the way for the development of novel bio-based plant growth promoters. In this context, microalgae biomass and derived agrochemicals offer novel sources of plant growth promotors that enhance crop productivity and impart disease resistance. These beneficial effects could be attributed to the presence of wide range of biomolecules such as soluble amino acid (AA), micronutrients, polysaccharides, phytohormones and other signaling molecules in microalgae biomass. In addition, their phototrophic nature, high photosynthetic efficiency, and wide environmental adaptability make them an attractive source of biostimulants, biofertilizers and biopesticides. The present review aims to describe the various plant growth promoting metabolites produced by microalgae and their effects on plant growth and productivity. Further, the effects elicited by microalgae biostimulants with respect to different modes of applications such as seed treatments, foliar spray and soil/root drenching is reviewed in detail. In addition, the ability of microalgae metabolites to impart tolerance against various abiotic and biotic stressors along with the mechanism of action is discussed in this paper. Although the use of microalgae based biofertilizers and biostimulants is gaining popularity, the high nutrient and water requirements and energy intensive downstream processes makes microalgae based technology commercially unsustainable. Addressing this challenge, we propose a circular economy model of microalgae mediated bioremediation coupled with biorefinery approaches of generating high value metabolites along with biofertilizer applications. We discuss and review new trends in enhancing the sustainability of microalgae biomass production by co-cultivation of algae with hydroponics and utilization of agriculture effluents.
Functions of nitric oxide-mediated post-translational modifications under abiotic stress
Authors: Mata-Pérez Capilla , Sánchez-Vicente Inmaculada , Arteaga Noelia , Gómez-Jiménez Sara , Fuentes-Terrón Andrea , Oulebsir Cylia Salima , Calvo-Polanco Mónica , Oliver Cecilia , Lorenzo Óscar
Published: March 2023

Environmental conditions greatly impact plant growth and development. In the current context of both global climate change and land degradation, abiotic stresses usually lead to growth restriction limiting crop production. Plants have evolved to sense and respond to maximize adaptation and survival; therefore, understanding the mechanisms involved in the different converging signaling networks becomes critical for improving plant tolerance. In the last few years, several studies have shown the plant responses against drought and salinity, high and low temperatures, mechanical wounding, heavy metals, hypoxia, UV radiation, or ozone stresses. These threats lead the plant to coordinate a crosstalk among different pathways, highlighting the role of phytohormones and reactive oxygen and nitrogen species (RONS). In particular, plants sense these reactive species through post-translational modification (PTM) of macromolecules such as nucleic acids, proteins, and fatty acids, hence triggering antioxidant responses with molecular implications in the plant welfare. Here, this review compiles the state of the art about how plant systems sense and transduce this crosstalk through PTMs of biological molecules, highlighting the S-nitrosylation of protein targets. These molecular mechanisms finally impact at a physiological level facing the abiotic stressful traits that could lead to establishing molecular patterns underlying stress responses and adaptation strategies.
RNA-seq analysis revealed considerable genetic diversity and enabled the development of specific KASP markers for Psathyrostachys huashanica
Authors: Zhang Hao , Zeng Chunyan , Li Liangxi , Zhu Wei , Xu Lili , Wang Yi , Zeng Jian , Fan Xing , Sha Lina , Wu Dandan , Cheng Yiran , Zhang Haiqin , Chen Guoyue , Zhou Yonghong , Kang Houyang
Published: March 2023

Psathyrostachys huashanica, which grows exclusively in Huashan, China, is an important wild relative of common wheat that has many desirable traits relevant for wheat breeding. However, the poorly characterized interspecific phylogeny and genomic variations and the relative lack of species-specific molecular markers have limited the utility of P. huashanica as a genetic resource for enhancing wheat germplasm. In this study, we sequenced the P. huashanica transcriptome, resulting in 50,337,570 clean reads that were assembled into 65,617 unigenes, of which 38,428 (58.56%) matched at least one sequence in public databases. The phylogenetic analysis of P. huashanica, Triticeae species, and Poaceae species was conducted using 68 putative orthologous gene clusters. The data revealed the distant evolutionary relationship between P. huashanica and common wheat as well as the substantial diversity between the P. huashanica genome and the wheat D genome. By comparing the transcriptomes of P. huashanica and Chinese Spring, 750,759 candidate SNPs between P. huashanica Ns genes and their common wheat orthologs were identified. Among the 90 SNPs in the exon regions with different functional annotations, 58 (64.4%) were validated as Ns genome-specific SNPs in the common wheat background by KASP genotyping assays. Marker validation analyses indicated that six specific markers can discriminate between P. huashanica and the other wheat-related species. In addition, five markers are unique to P. huashanica, P. juncea, and Leymus species, which carry the Ns genome. The Ns genome-specific markers in a wheat background were also validated regarding their specificity and stability for detecting P. huashanica chromosomes in four wheat–P. huashanica addition lines. Four and eight SNP markers were detected in wheat–P. huashanica 2Ns and 7Ns addition lines, respectively, and one marker was specific to both wheat–P. huashanica 3Ns, 4Ns, and 7Ns addition lines. These markers developed using transcriptome data may be used to elucidate the genetic relationships among Psathyrostachys, Leymus, and other closely-related species. They may also facilitate precise introgressions and the high-throughput monitoring of P. huashanica exogenous chromosomes or segments in future crop breeding programs.
Uses of 360° video in referees' reflectivity training: Possibilities and limitations
Authors: Boyer Simon , Rochat Nadège , Rix-Lièvre Géraldine
Published: March 2023

Introduction

A pedagogical innovation backed by an online device using 360° video had been devised to train young team sports referees (handball, soccer, rugby) to be more reflective. The objective of this exploratory research was to investigate the ways young student referees use 360° videos in allo-confrontation when carrying out some exercises involving open questions about their viewing experience.

Methods

Student referees' answers were recorded. A grounded analysis of these answers enabled us not only to identify their main focuses when viewing the 360° videos but also to distinguish different cognitive stances.

Results

The grounded analysis revealed (1) idiographic differences between student referees in the video sequencing, although the participants seemed to share the same reference points, (2) two kinds of focus, one on the unfolding of the game and another one on the referee peer's activity, and (3) different perspectives according to which student referees use video and to initiate a reflection on a differentiation of several types of immersion: empathetic, simulation, exploratory.

Discussion

This study highlighted the conditions under which referees' reflectivity was fostered by the use of 360° video during allo-confrontation. Some perspectives for the evolution of 360° video supports for designing training courses for referees are proposed.
Taking the mystery away from shared intentionality: The straightforward view and its empirical implications
Authors: Vincini Stefano
Published: March 2023

Ordinary language in Western and non-Western cultures individuates shared mental states or experiences as unitary interpersonal events that belong to more than one individual. However, a default assumption in modern Western thought is that, in this regard, ordinary language is either illusory or merely metaphorical: a mental state or experience can belong to only one person. This assumption is called Cartesian eliminativism and is often taken to be foundational in psychology. It follows that any view that contradicts Cartesian eliminativism isa priorisuspected of being “mysterious,” i.e., of not meeting scientific standards. This paper suggests that the very opposite may be the case. The straightforward view explains how individuals assemble and experience a shared mental state as a unitary whole whose components are distributed among the participants. The naturalistic advantages of such a view are brought to light by focusing on developmental science. Since it explains early shared emotions, goals, and attention merely by relying on domain-general, associative processes, the straightforward view is more parsimonious than current psychological theories. Indeed, it abandons the cumbersome postulates of (i) multi-level recursive mindreading and (ii) a special, conceptually elusive phenomenal quality. I outline the distinctive developmental predictions of the view and discuss how it accounts for the functions of shared mental states. As a reductionist, non-eliminativist approach, the straightforward view promises to be viable also for cognitive scientists who have so far worked within the Cartesian framework due to a lack of a rigorous and sufficiently developed alternative.
Probabilistic reinforcement precludes transitive inference: A preliminary study
Authors: Camarena Héctor O. , García-Leal Óscar , Delgadillo-Orozco Julieta , Barrón Erick
Published: March 2023

In the basic verbal task from Piaget, when a relation of the form if A > B and B > C is given, a logical inference A > C is expected. This process is called transitive inference (TI). The adapted version for animals involves the presentation of a simultaneous discrimination between stimuli pairs. In this way, when A+B−, B+C−, C+D−, D+E− is trained, a B>D preference is expected, assuming that if A>B>C>D>E, then B>D. This effect has been widely reported using several procedures and different species. In the current experiment TI was evaluated employing probabilistic reinforcement. Thus, for the positive stimuli a .7 probability was administered and for the negative stimuli a .3 probability was administered. Under this arrangement the relation A>B>C>D>E is still allowed, but TI becomes more difficult. Five pigeons (Columba Livia) were exposed to the mentioned arrangement. Only one pigeon reached the criterion in C+D− discrimination, whereas the remaining did not. Only the one who successfully solved C+D− was capable of learning TI, whereas the others were not. Additionally, it was found that correct response ratios did not predict BD performance. Consequently, probabilistic reinforcement disrupted TI, but some positional ordering was retained in the test. The results suggest that TI might be affected by associative strength but also by the positional ordering of the stimuli. The discussion addresses the two main accounts of TI: the associative account and the ordinal representation account.
Smoking and attention in schizophrenia spectrum disorders: What are we neglecting?
Authors: Keřková Barbora , Knížková Karolína , Siroňová Aneta , Hrubý Aleš , Večeřová Monika , Šustová Petra , Jonáš Juraj , Rodriguez Mabel
Published: March 2023

Introduction

Individuals with schizophrenia spectrum disorders (SSDs) record elevated rates of smoking, which is often attributed to their effort to self-medicate cognitive and attentional symptoms of their illness. Empirical evidence for this hypothesis is conflicting, however. In this study, we aimed to test predictions derived from the cognitive self-medication hypothesis. We predicted that cigarette smoking status and extent would predict the attentional performance of participants with SSDs. Simultaneously, we wished to address methodological gaps in previous research. We measured distinct attentional components and made adjustments for the effects of other, attention-modulation variables.

Methods

Sixty-one smokers (82.0% males, 26.73 ± 6.05 years) and 61 non-smokers (50.8% males, 27.10 ± 7.90 years) with recent-onset SSDs completed an X-type Continuous Performance Test, which was used to derive impulsivity and inattention component scores. Relationships between the two component scores and cigarette smoking status and extent were assessed using hierarchical regression. Effects of estimated premorbid intellectual functioning and antipsychotic medication dosage were held constant.

Results

Smokers had significantly higher inattention component scores than non-smokers when covariates were controlled (p = 0.026). Impulsivity remained unaffected by smoking status (p = 0.971). Cigarette smoking extent, i.e., the number of cigarettes smoked per day, was not associated with either inattention (p = 0.414) or impulsivity (p = 0.079).

Conclusion

Models of smoking-related attentional changes can benefit from the inclusion of sample-specific component scores and attention-modulating covariates. Under these conditions, smokers with SSDs can show a partial attentional benefit. However, the limited scope of this benefit suggests that the cognitive self-medication hypothesis requires further testing or reconsidering.
An exploration of happiness, anxiety symptoms, and depressive symptoms among older adults during the coronavirus pandemic
Authors: Serrao Hill Melanie M. Y. , Hauck Nancy , Yorgason Jeremy B. , Bown Caroline , Tankersley Kortney
Published: March 2023

The COVID-19 pandemic has affected millions of people worldwide. Because of the challenges associated with the pandemic, universal levels of happiness have likely depleted. We know little about how those with prior existing mental health concerns have responded to the pandemic. Using cross-sectional (study 1; N = 1,366) and longitudinal (study 2; N = 262) data, we utilized a stress and resilience perspective to explore mental health symptoms and happiness among older adults before and after the declaration of the pandemic. Results for both studies indicated higher levels of depression and anxiety symptoms predicted lower levels of happiness; however, for those who indicated higher levels of mental health symptoms, post-pandemic declaration happiness levels were higher than pre-pandemic happiness levels. Findings suggest that resilience may be learned throughout a lifetime, and that experiences from prior stressors may show benefits in responding to future ones, even among vulnerable populations.
Cross-cultural adaptation of Chinese international students: Effects of distant and close support-seeking
Authors: Zheng Shaofeng , Ishii Keiko
Published: March 2023

Introduction

Social support-seeking is considered to be an effective way for international students to cope with their acculturative stress and contribute to cross-cultural adaptation. In addition to support from people in the host country (close support), the ease of online communication now allows international students to receive additional support from people back in their home country (distant support). However, little research has investigated whether distant support works as effectively as close support. In two studies, we examined the differential effect of distant and close support-seeking on the psychological adaptation of Chinese international students in the host country and how acculturation orientations relate to the use of these two types of support.

Methods

Chinese international students in Japan (Study 1; N = 172) and the United States (Study 2; N = 118) completed an online survey that assessed participants’ host/home culture orientation, distant emotional/instrumental support-seeking, close emotional/instrumental support-seeking, and psychological adaptation.

Results

Results showed that distant emotional support-seeking negatively predicted psychological adaptation in the host country. Nevertheless, distant emotional support-seeking alleviated feelings of loneliness in Chinese international students as close emotional support-seeking did (Study 2). Also, the results showed that international students with higher home-culture orientation sought more distant support, whereas those with higher host-culture orientation sought more close support. Further, Chinese-culture orientation increased distant emotional support-seeking, decreasing psychological adaptation as well as loneliness.

Discussion

These findings highlight the importance of considering the source and types of support when discussing the implications of social support for the cross-cultural adaptation of international students.
Development of Chinese food picture library for inducing food cravings
Authors: Cai Hui-Ting , Zhang Hong-Wei , Zheng Hui , Xu Ting , Liu Lin , Ban Xu-Yan , Di Jian-Zhong , Yuan Ti-Fei , Han Xiao-Dong
Published: March 2023

Cue-induced food cravings are strong desires directed toward specific foods, usually ones with high caloric content, and can lead to overeating. However, although food cravings vary according to individual preferences for specific high-calorie food subtypes, a structured library of food craving-inducing pictures including multiple categories of high-calorie foods does not yet exist. Here, we developed and validated a picture library of Chinese foods (PLCF) consisting of five subtypes of high-calorie foods (i.e., sweets, starches, salty foods, fatty foods, and sugary drinks) to allow for more nuanced future investigations in food craving research, particularly in Chinese cultural contexts. We collected 100 food images representing these five subtypes, with four food items per subtype depicted in five high-resolution photographs each. We recruited 241 individuals with overweight or obesity to rate the food pictures based on craving, familiarity, valence, and arousal dimensions. Of these participants, 213 reported the severity of problematic eating behaviors as a clinical characteristic. Under the condition of mixing multiple subtypes of high-calorie foods, we did not observe significant differences in craving ratings for high- and low-calorie food images (ptukey> 0.05). Then, we compared each subtype of high-calorie food images to low-calorie ones, and found craving ratings were greater for the images of salty foods and sugary drinks (ps< 0.05). Furthermore, we conducted a subgroup analysis of individuals according to whether they did or did not meet the criteria for food addiction (FA) and found that greater cravings induced by the images of high-calorie food subtypes (i.e., salty foods and sugary drinks) only appeared in the subgroup that met the FA criteria. The results show that the PLCF is practical for investigating food cravings.
The impact of online office on social anxiety among primary and secondary school teachers—Considering online social support and work intensity
Authors: Xie Yating
Published: March 2023

The COVID-19 has had a major impact on the global education system. In order to ensure the normal implementation of education courses, governments and education departments around the world have taken corresponding emergency measures. Based on data from 384 validated questionnaires, this study explored the effects of teleworking practices, work intensity, and online social support on social anxiety among primary and secondary school teachers. The results found that teleworking was more likely to cause social anxiety among teachers, while work intensity could promote social anxiety and online social support could reduce the probability of social anxiety. Work intensity can weaken the influence of partner support on social anxiety. Moreover, the model path coefficients differed across work styles. Based on the results, this study proposes some policy recommendations in order to provide theoretical guidance for improving social anxiety among primary and secondary school teachers and promoting the quality of educational work.
The impact of stereotype threat on endogenous poverty-elimination dynamics in generationally poor individuals
Authors: Wu Na , Fu Anguo , Liu Yangxiong , Yue Tong , Li Jibo , Wang Xiaogang , Huang Xiting
Published: March 2023

Introduction

The study examines the impact of stereotype threat on generationally poor individuals and its effect on achievement motivation. It also explores the extent to which self-affirmation has an intervention effect on the negative impact of stereotype threat.

Methods and results

In Study 1, statements that contained negative stereotypes were used to elicit stereotype threat in generationally poor individuals; the results show that stereotype threat reduced the performance of generationally poor individuals in a mental-rotation task. Study 2 used a questionnaire to measure the endogenous dynamics of generationally poor individuals attempting to escape poverty after experiencing stereotype threat; participants in the stereotype-threat group showed lower-level endogenous poverty-elimination dynamics than those in the control group. In Study 3, a self-affirmation intervention was administered to the stereotype-threat group after the stereotype threat was induced. Participants in the self-affirmation group were shown to have higher-level endogenous poverty-elimination dynamics than those in the control group.

Discussion

These findings confirm the negative effect of stereotype threat on endogenous poverty-elimination dynamics and verify the effectiveness of self-affirmation in mitigating the negative effects of stereotype threat.
Designing and validating an adaptation questionnaire among the husbands of Iranian Muslim women with breast cancer
Authors: Bigdeli Shamloo Marzieh Beigom , Elahi Nasrin , Asadi Zaker Marziyeh , Zarea Kourosh , Zareiyan Armin
Published: March 2023

Background

Breast cancer is the most common cancer among women and is the second leading cause of cancer death. This disease affects all aspects of the patient's life and family, especially the patient's spouse, which confirms the need to adapt to these changes. The common instruments used for the investigation of adaptation among husbands of women with breast cancer are mainly outdated, one-dimensional, or non-concordant with the Iranian culture. Therefore, the present study aimed to design and validate an adaptation scale among the husbands of Iranian Muslim women suffering from breast cancer.

Methods

This exploratory sequential mixed study was conducted in two qualitative and quantitative stages. In the qualitative stage, semi-structured interviews were performed with 21 participants. Then, items were developed through content analysis using the approach proposed by Elo and Kyngas on the basis of Roy's adaptation model. In the quantitative stage, the extracted items were reduced and psychometric properties such as face, content, and construct validity as well as reliability were explored. To investigate the construct validity, a cross-sectional descriptive study was conducted on 300 husbands of women with breast cancer selected via cluster sampling.

Results

The initial questionnaire contained 79 items. After the assessment of face and content validity, 59 items were evaluated regarding construct validity using exploratory factor analysis. At this stage, six adaptation dimensions were observed among the women's husbands, with the variance of 51.71. The Cronbach's alpha and correlation coefficient of the questionnaire were 0.912 and 0.701, respectively.

Conclusion

The developed 51-item adaptation scale had an appropriate validity and reliability and could be used for the assessment of adaptation in the target group.
“Beyond just the four walls of the clinic”: The roles of health systems caring for refugee, immigrant and migrant communities in the United States
Authors: Abudiab Seja , de Acosta Diego , Shafaq Sheeba , Yun Katherine , Thomas Christine , Fredkove Windy , Garcia Yesenia , Hoffman Sarah J. , Karim Sayyeda , Mann Erin , Yu Kimberly , Smith M. Kumi , Coker Tumaini , Dawson-Hahn Elizabeth
Published: March 2023

This article is part of the Research Topic ‘Health Systems Recovery in the Context of COVID-19 and Protracted Conflict’

Introduction

Refugee, immigrant and migrant (hereafter referred to as “immigrant”) communities have been inequitably affected by the COVID-19 pandemic. There is little data to help us understand the perspectives of health systems on their role, in collaboration with public health and community-based organizations, in addressing inequities for immigrant populations. This study will address that knowledge gap.

Methods

This qualitative study used semi-structured video interviews of 20 leaders and providers from health systems who cared for immigrant communities during the pandemic. Interviewees were from across the US with interviews conducted between November 2020–March 2021. Data was analyzed using thematic analysis methods.

Results

Twenty individuals representing health systems participated with 14 (70%) community health centers, three (15%) county hospitals and three (15%) academic systems represented. The majority [16 health systems (80%)] cared specifically for immigrant communities while 14 (70%) partnered with refugee communities, and two (10%) partnered with migrant farm workers. We identified six themes (with subthemes) that represent roles health systems performed with clinical and public health implications. Two foundational themes were the roles health systems had building and maintaining trust and establishing intentionality in working with communities. On the patient-facing side, health systems played a role in developing communication strategies and reducing barriers to care and support. On the organizational side, health systems collaborated with public health and community-based organizations, in optimizing pre-existing systems and adapting roles to evolving needs throughout the pandemic.

Conclusion

Health systems should focus on building trusting relationships, acting intentionally, and partnering with community-based organizations and public health to handle COVID-19 and future pandemics in effective and impactful ways that center disparately affected communities. These findings have implications to mitigate disparities in current and future infectious disease outbreaks for immigrant communities who remain an essential and growing population in the US.
What has affected the governance effect of the whole population coverage of medical insurance in China in the past decade? Lessons for other countries
Authors: Zhang Ting , Zhang Hongyu , Miao Wenqing , Xu Jinpeng , Shi Qi , Liu Jian , Deng Fangmin , He Jingran , Chen Fangting , Kang Zheng , Wu Qunhong , Tian Guomei
Published: March 2023

Objective

This study aimed to explore the current state of governance of full population coverage of health insurance in China and its influencing factors to provide empirical references for countries with similar social backgrounds as China.

Methods

A cross-sectional quantitative study was conducted nationwide between 22 January 2020 and 26 January 2020, with descriptive statistics, analysis of variance, and logistic regression models via SPSS 25.0 to analyze the effectiveness and influencing factors of the governance of full population coverage of health insurance in China.

Results

The effectiveness of the governance relating to the total population coverage of health insurance was rated as good by 59% of the survey respondents. According to the statistical results, the governance of the public's ability to participate in insurance (OR = 1.516), the degree of information construction in the medical insurance sector (OR = 2.345), the government's governance capacity (OR = 4.284), and completeness of the government's governance tools (OR = 1.370) were all positively correlated (p < 0.05) on the governance effect of the whole population coverage of health insurance.

Conclusions

The governance of Chinese health insurance relating to the total population coverage is effective. To effectively improve the effectiveness of the governance relating to the total population coverage of health insurance, health insurance information construction, governance capacity, and governance tools should be the focus of governance to further improve the accurate expansion of and increase the coverage of health insurance.
Who uses technical aids in old age? Exploring the implementation of technology-based home modifications in Europe
Authors: Schmidt Laura I. , Wagner Melanie , Büßecker Hanna A. , Franke Annette A.
Published: March 2023

Introduction

Home modifications and features, e.g., handrails or ramps for people using wheelchairs, should allow residents with functional limitations to maintain social participation, health, and wellbeing for aging in place. However, there is little evidence in relation to the individual characteristics shaping this implementation of technology-based home modifications. Current studies often focus on describing the distribution of certain implementations in households but do not provide information on factors predicting the implementation or detailed and multifaceted data on associations with characteristics of the older user. This article, therefore, examines the use of well-established technological aids and home modifications (e.g., ramps, handrails, automatic doors, bathroom or kitchen modifications, chair lifts, and alerting devices) in the households of older adults in Europe. We refer to Lawton's and Nahemow's concept of personal-environment fit and describe the use of technical aids across 18 countries, analyze associations with individual characteristics and social resources, and compare those associations and variance explanation between older adults in their third age (“young-old”, 65–79 years) and older adults in their fourth age (“old-old”, 80+).

Methods

Drawing on representative data from the Survey of Health, Ageing, and Retirement in Europe (SHARE), wave 6, a total of N = 38,553 older adults aged 65–105 years (M = 74.4 years, SD = 7.1; 55% women) were analyzed by performing hierarchical logistic regression analyses.

Results

Indicators of functioning explained the highest proportion of variance, followed by social resources, and variance explanation was higher for the fourth age than for the third age. In particular, older adults with physical limitations, a larger social network, and those who received care from a child outside the household were more likely to have home modifications installed.

Discussion

The study provides an overview of associations of diverse variables with assistive devices and modifications in the home and can serve as a starting point for public health activities concerning the heterogeneity of people aged 65 years and older.
Restorative perception of urban streets: Interpretation using deep learning and MGWR models
Authors: Han Xin , Wang Lei , He Jie , Jung Taeyeol
Published: March 2023

Restorative environments help people recover from mental fatigue and negative emotional and physical reactions to stress. Excellent restorative environments in urban streets help people focus and improve their daily behavioral performance, allowing them to regain efficient information processing skills and cognitive levels. High-density urban spaces create obstacles in resident interactions with the natural environment. For urban residents, the restorative function of the urban space is more important than that of the natural environment in the suburbs. An urban street is a spatial carrier used by residents on a daily basis; thus, the urban street has considerable practical value in terms of improving the urban environment to have effective restorative function. Thus, in this study, we explored a method to determine the perceived restorability of urban streets using street view data, deep learning models, and the Ordinary Least Squares (OLS), the multiscale geographically weighted regression (MGWR) model. We performed an empirical study in the Nanshan District of Shenzhen, China. Nanshan District is a typical high-density city area in China with a large population and limited urban resources. Using the street view images of the study area, a deep learning scoring model was developed, the SegNet algorithm was introduced to segment and classify the visual street elements, and a random forest algorithm based on the restorative factor scale was employed to evaluate the restorative perception of urban streets. In this study, spatial heterogeneity could be observed in the restorative perception data, and the MGWR models yielded higher R2 interpretation strength in terms of processing the urban street restorative data compared to the ordinary least squares and geographically weighted regression (GWR) models. The MGWR model is a regression model that uses different bandwidths for different visual street elements, thereby allowing additional detailed observation of the extent and relevance of the impact of different elements on restorative perception. Our research also supports the exploration of the size of areas where heterogeneity exists in space for each visual street element. We believe that our results can help develop informed design guidelines to enhance street restorative and help professionals develop targeted design improvement concepts based on the restorative nature of the urban street.