bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Component Elements and Interaction of Environmental Ceramic Works Facing Public Art Category
Authors: Zhang Huixin
Published: December 2021

Objectives: With the development of modern ceramic art and public art, environmental ceramic art, as a new form of public art, has appeared in many fields of public space. Methods: Environmental ceramic art also has a close interactive relationship with urban culture and
is the value embodiment of urban culture. This article will study the composition and interaction of environmental ceramic art works facing the public art category. Results: Research shows that environmental ceramic art adds dazzling highlights to public art with its special artistic
language and performance connotation. Public art also expands the development space due to the involvement of environmental ceramic art. Conclusion: Today, when public art has become the symbol of modern civilization, the environmental ceramics, which is based on modern ceramic art
murals and ceramic sculptures, is applied to the environmental space of modern architecture, bringing a unique artistic feeling to modern public art.
Analysis on the Improvement Strategies of College Students’ Sub-Health Psychological Status from the Perspective of Music Education
Authors: Zhao Yan
Published: December 2021

Objectives: College stage is a critical period for students to become mature and independent, and it is also a period of rapid changes in physical and mental development. Methods: They need not only good ideological and moral qualities, scientific and cultural qualities
and strong body, but also good psychological characteristics. With the implementation of the enrollment expansion policy in colleges and universities, the number of college students has increased sharply, and the mental health problems of college students have become more prominent. Results:
Many students are in a state of psychological abnormality, but they have not reached the degree of illness, that is, mental sub-health state. In the current high-speed development society, college students are facing more pressures and challenges due to academic, employment, economic, emotional
and other comprehensive factors such as uncoordinated interpersonal relationships. Music education, as an aesthetic education, plays a unique role in adjusting the sub-health psychology of college students. Conclusion: This paper discusses the promotion of college music education to
the development of college students’ mental health, and analyzes the methods of improving college students’ mental sub-health state by college music education.
English Sociological Terminology Based On Functional Equivalence Theory
Authors: Xu Cuiping
Published: December 2021

Objectives: In the practice of translating English, there are often situations that may lead to missing words. In this case, a computer technology is needed to improve the translation studies of sociological terms in English. This time, based on the characteristics of Internet
network data, intelligent robot information is extracted. Methods: According to the knowledge ontology constructed this time, based on the functional equivalence theory, a method based on the automatic construction of the ontology library in the party building domain is proposed. Results:
In order to verify the proposed method algorithm, the example study of some sociological terms conceptual terms above the interactive encyclopedia is studied by the ontology created by encyclopedia resources, such as father/sub-relationship, class and instance relationship and attribute relationship,
and a total of 72474 relationships are obtained through the final statistical study. Conclusion: From the overall analysis, it can be seen that the sociological terminology research of English computer network based on functional equivalence theory can achieve a good classification
effect.
Speed Skating Technical Training Based on Sports Biomechanics
Authors: Lu Zhuo , Zhang Shouwei , Yang Xu
Published: December 2021

Objectives: With the vigorous development of China’s sports industry, sports industry has displayed its own sports spirit on the world stage, especially in the speed skating sports. Methods: The combination of sports biomechanics and speed skating training not only
helps to improve our speed skating level, but also helps to inherit the tradition of combining sports theory and practice in our country. Results: The speed skating technique based on sports biomechanics can use the knowledge of biomechanics to combine speed skating with mechanical
system better. Conclusion: The high-speed camera can be used to collect the players’ training, and the frame rate adjustment function of the computer can be used for frame by frame analysis to ensure the posture correctness of the speed skaters.
Evaluation of Attorney’s Law in Terms of Administrative Law
Authors: Zhu Kongze , Zheng Lei
Published: December 2021

Advocacy aims at providing legal assistance in fairly resolving legal disputes. It is a fact that there is a public interest in the performance of this activity. A lawyer performs this activity under the supervision and control of the bar association. Public service is the professional
activity carried out by the lawyer/ advocate. This paper evaluated public service in terms of accountability to public officials and administrative organizations. In terms of public service, attorneyship has been examined both organically and financially. In terms of the administrative organization,
the professional organizations in the form of public institutions - the bar associations which are the professional organizations of the lawyers - and the admission of a lawyer to the legal profession were evaluated in this paper.
Innovación en ELT
Authors: Alvarez Mónica
Published: December 2021

Entre las diferentes formas de aprender y enseñar inglés como lengua extranjera plantea una forma innovadora y social, el aprendizaje autónomo de lenguas. Es hoy en dia proporciona nuevas ideas, entornos e implicaciones pedagógicas que transforman El papel de los profesores, estudiantes e instituciones en el proceso de aprendizaje de un extranjero. idioma. Así, el objetivo principal de esta investigación es identificar en el campo de la aprendizaje autónomo del idioma, algunos comportamientos revelados en el uso de los estudiantes de recursos del centro de auto-acceso a través de la implementación de tareas. En la primera parte de este trabajo de investigación, hay una justificación del proyecto. Segundo, Se presentan las preguntas de investigación, las subpreguntas y los objetivos de la investigación. En tercer lugar, se ofrece una revisión de la literatura relacionada con el aprendizaje autónomo de idiomas. A definición, sus tres versiones, características en las que el lenguaje autónomo el aprendizaje se puede identificar, y varias estrategias de aprendizaje relacionadas con este proyecto son mostrado. En cuarto lugar, el tema relacionado con el centro de autoacceso, sus requisitos, tipología, Se define el papel del profesor y de los alumnos para desarrollar el aprendizaje autónomo del idioma. En quinto lugar, el diseño de investigación en el que los participantes, la descripción del entorno educativo, Se explican los instrumentos y procedimientos de recopilación de datos. Sexto, el instructivo el diseño señala el uso de tareas dentro del proyecto. Séptimo, el análisis de datos. proporcionar a los estudiantes muestras y opiniones se organiza por tareas. Finalmente, los resultados y se explican las conclusiones que surgieron de los datos.
A study on susceptibility patterns, resistance mechanisms and cross- resistances of antibiotics against Pseudomonas aeruginosa in a teaching hospital at Puducherry
Authors: Gurumurthy Hemalatha , Poongothai G K , Bhaskaran K
Published: December 2021

, a gram negative bacteria causes lung and nosocomial infections, mostly infect the body after surgery or invasive techniques. There has been a increasing prevalence in drug resistant variants in the recent years.

1. To determine the antibiotic susceptibility patterns of ; 2. To assess the antibiotics used against and the cross-resistence pattern existing between them; 3. To evaluate the possible resistance mechanisms of by phenotypic techniques.

Thirty six consecutive, nonduplicate isolates were collected between January to July in the year 2018 from the hospital pus samples. The isolates showed synthesis of pyocyanin and a oxidase positive reaction. Kirby bauer’s disc diffusion method (HIMEDIA). was used for assessing the sensitivity of drugs. Disk approximation test was done to check the prevalence of inducible β-lactamases. Modified Hodge test was done to assess the metallo-β-lactamase activity. Double disk synergy method had been preferred to evaluate the extended-spectrum beta-lactamase (ESBL) activity.

The most sensitive antibiotic was found to be ciprofloxacin which is followed by amikacin and ceftazidime (p < 0.05). 36% of the samples were resistant to more than one antibiotic groups. Cross-resistance was observed between the antibiotics. 53% of the samples had Inducible β-lactamases. Eighty percent of the samples which were non-resistant to ceftazidime showed positive reaction for inducible beta-lactamase. 2% isolates by DDS method showed the presence of ESBLs. The study samples did not show the presence of Metallo-β-lactamases.

Strict adherence to the recent trend of “reserve drugs” concept and minimizing the misuse of antibiotics can bring down the drug resistance and morbidity. The addressal of irrational and inappropriate use of antimicrobials among the clinician is the need of the hour.
Diversidad de mariposas (Lepidoptera: Hesperioidea- Papilionoidea) en dos zonas del departamento del Vaupés, Colombia
Authors: Díaz-Urbina Paola , Andrade-C. M. Gonzalo , Vásquez-Ramos Jesús Manuel
Published: December 2021

En algunos lugares de Colombia aún hay vacíos en cuanto al conocimiento de la fauna, específicamente de la diversidad lepidopterológica, debido a su lejanía y acceso limitado, como los resguardos indígenas de la región amazónica. El objetivo de este trabajo fue caracterizar la diversidad de mariposas diurnas en dos zonas del departamento del Vaupés correspondientes a las comunidades indígenas de Puerto Inayá, Wasay, Puerto Paloma y Villa Fátima y en dos temporadas climáticas. Los muestreos se realizaron en la temporada de invierno, julio a septiembre del 2017, y en la de verano, enero a marzo del 2018. En cada comunidad los organismos se recolectaron durante cinco días entre las 7:00 y las 18:00 horas con jama y trampas van Someren Rydon (VSR) empleando dos tipos de cebo (fruta fermentada y pescado descompuesto) en lugares distribuidos verticalmente en tres estratos (sotobosque: 1m, estrato intermedio: 5m y dosel: 10m). Se registraron 2.199 ejemplares de 272 especies y 123 subespecies, 6 familias y 18 subfamilias, y se reportaron dos nuevos registros y tres ampliaciones de distribución en el país. Con el uso de red entomológica se registró el 76 % de la abundancia. La riqueza total estimada para el Vaupés se incrementó de 453 especies a 559 especies. A nivel espacial y temporal la composición de especies fue significativamente diferente en las cuatro comunidades y las dos temporadas, aunque se presentaron solapamientos, con varias especies compartidas.
Myślenie widzenia
Authors: Olek Jerzy
Published: December 2021

Świadomy odbiór dzieł sztuki zawsze wymagał ze strony widza odpowiedniego przygotowania. Z czasem potrzeba wyspecjalizowanej kompetencji odbiorcy stała się wręcz niezbywalna, co szczególnie nasiliło się w pierwszych dekadach XX wieku, kiedy to niezwykle skomplikowały się narracje wizualne, formułowane za pośrednictwem wyrafinowanych języków. Przyczyniła się do tego w znacznym stopniu abstrakcja, która niosła powstającymi w jej obrębie formami zupełnie nowe sensy. Skończył się czas dosłownej referencyjności. Sztuka przestała być prostym zwierciadłem, odbijającym zrozumiale dookolną rzeczywistość.
Kulturowy wymiar wolności religijnej a wychowanie. Współczesne znaczenie Deklaracji o wolności religijnej
Authors: Grzybek Grzegorz
Published: December 2021

Celem artykułu było z jednej strony podkreślenie kulturowych przemian w zakresie religijności, których wyrazem jest Deklaracja o wolności religijnej Soboru Watykańskiego II, zaś z drugiej wskazanie na wychowanie do wolności religijnej, które winno wiązać się z wychowaniem do szczęścia oraz ze sztuką życia. Wychowanie do szczęścia oraz umiejętność sztuki życia opierają się na wolności wyboru, a także godności osoby ludzkiej.
İnşaat Sektöründeki İş Kazalarının Hata Ağacı Analizi ile Değerlendirilmesi
Authors: GÖKÇE Şerife , ZORLUER İsmail
Published: December 2021

İnşaat sektörü hem dünyada hem de Türkiye’de en çok iş kazasının yaşandığı sektörlerin başında gelmektedir. Ölüm, yaralanma, sürekli iş görmezlik veya meslek hastalıklarıyla sonuçlanan iş kazalarının nedenlerinin belirlenmesi, iş kazalarına karşı önlemler alınması güncelliğini koruyan önemli bir problemdir.
Bu çalışma kapsamında Türkiye’de inşaat sektöründe farklı zamanlarda meydana gelen iş kazalarının ölüm ve yaralanma oranlarından yararlanılarak hata ağacı analizi gerçekleştirilmiştir. Hata ağacının istenmeyen tepe olayı, iş kazası olarak tanımlanmıştır. Hata ağacı yapısı, iş kazalarını ve nedenlerini ilişkilendiren minimum kesme kümelerinden oluşmaktadır. Tümdengelimsel bir yaklaşımla hesaplamaların gerçekleştirildiği hata ağacı analizinde, minimum kesme kümelerinin ve istenmeyen tepe olayın hata olasılığı değerleri hesaplanırken Boolean matematiğinden yararlanılmaktadır.
Çalışma kapsamında hem iş kazalarının meydana gelme olasılıkları hem de hata olarak tanımlanan iş kazalarının kritik önem faktörleri ortaya konmuştur. İş kazalarına karşı alınacak önlemler sıralamasında, göreceli olarak minimum kesme kümelerinin olasılık değerleri dikkate alınabileceği gibi kritik önem faktörlerinin de bir sıralama ölçütü olarak kullanılabileceği sonucuna varılmıştır. Çalışma, hata ağacı analizinin Türkiye’deki iş kazalarının analizinde etkin bir şekilde kullanılabileceğini göstermektedir. Ayrıca bu çalışmada oluşturulan hata ağacı yapısı ile yetkili mercilerin gerekli önlemleri alabilmesi açısından görsel bir model ortaya koyulmuştur.
Image Classification Using Transfer Learning and Deep Learning
Authors: Desai Chitra
Published: December 2021

Deep learning models have demonstrated improved efficacy in image classification since the ImageNet Large Scale Visual Recognition Challenge started since 2010. Classification of images has further augmented in the field of computer vision with the dawn of transfer learning. To train a model on huge dataset demands huge computational resources and add a lot of cost to learning. Transfer learning allows to reduce on cost of learning and also help avoid reinventing the wheel. There are several pretrained models like VGG16, VGG19, ResNet50, Inceptionv3, EfficientNet etc which are widely used.   This paper demonstrates image classification using pretrained deep neural network model VGG16 which is trained on images from ImageNet dataset. After obtaining the convolutional base model, a new deep neural network model is built on top of it for image classification based on fully connected network. This classifier will use features extracted from the convolutional base model.
Evaluation of the Effect of Mesenchymal Stem Cells on Cisplatin Induced Toxicity in Neuroblastoma Tumor Model
Authors: Aktas Safiye , Olgun Yüksel , Evin Hande , Erçetin Ayşe Pınar , Aktaş Tekincan Çağrı , Yılmaz Osman , Kırkım Günay , Olgun Hatice Nur
Published: December 2021

Objective: High-dose cisplatin (CDDP) causes dose-limiting side effects in neuroblastoma (NB) treatment. Mesenchymal stem cells (MSC) are a current research area. The aim of this study is to assess the interaction of MSC with CDDP in nude mouse NB model.
Methods: Athymic male nude mice (n=28) thatbhad basal auditory tests, with subcutaneous NB were randomized to control, CDDP, MSC and CDDP+MSC treatment groups. Seven days later, hearing tests were repeatedand the animals were sacrificed. Necrosis, apoptosis and viabilitywere assessed in tumors. MSC rate within the tumor was assessed with flow cytometry for triple CD34+ CD44+ and CD117- expression. Expression of the cochlear cell proteins of calretinin, math-1 and myosin2A were immunohistochemically assessed.
Results: Tumor tissues were found to have statistically significantly higher levels of necrosis in CDDP and CDDP+MSC groups. MSC did not change the tumor dimensions in the CDDP group. MSC group had higher triple CD34+ CD44+ and CD117- expression within tumor tissue compared to the control and CDDP groups. In the inner ear, the expression of cochlear cell proteins calretinin, math-1 and myosin2A were identified to be highest in MSC group. 15-decibel loss at 12, 16, 20 and 32 kHz frequencies with CDDP was resolved with MSC administration.
Conclusion: MSC prevented hearing loss caused by CDDP without disrupting the antitumor effect of CDDP. Systemic MSC may be assessed for clinical use to reduce the side effects of CDDP.
Sistema arrecifal mesoamericano: daños por cambio climático y encallamientos
Authors: Gallegos Rojano Iliana Zamira , Salazar López Alfredo , Martínez-Rodríguez María Concepción
Published: December 2021

Los impactos a los ecosistemas marinos son variados y poco visibles, en la presente investigación mostramos los daños de una parte del sistema de arrecifes Mesoamericano por distintos factores entre ellos el cambio climático y los encallamientos. Mediante el análisis de las Áreas Naturales Protegidas de México que forman parte del sistema, se tiene que durante 10 años se han perdido 8,798.55 m2 de arrecifes, aunque los impactos están disminuyendo en los últimos años, aún no tenemos la seguridad de que esto esté controlado.
Articulações teóricometodológicas em uma experiência etnográfica com adolescentes
Authors: Satler Lara Lima , Carrijo Ana Júlia de Freitas
Published: December 2021

Neste artigo, propomos caminhos para investigar os modos pelos quais adolescentes participam dos circuitos de produção de sentido na internet. Trata-se de uma pesquisa qualitativa, feita com um grupo de doze adolescentes goianos, na faixa etária de quinze a dezessete anos, estudantes de uma escola estadual em Aparecida de Goiânia, Goiás. Aqui, faremos uma análise dos procedimentos adotados na pesquisa de campo, fundamentada teoricamente nos Estudos da Cultura Latino-Americanos. O objetivo é elaborar uma proposta viável de realização de pesquisa empírica no campo da Comunicação, partindo dos usos sociais do YouTube e do Instagram, plataformas constituídas por múltiplos recursos audiovisuais populares entre os entrevistados. Portanto, a partir da combinação de técnicas etnográficas de produção de dados, tais como observação participante, discussão em grupo e entrevistas individuais em profundidade, mapeamos e discutimos os processos de circulação e ressignificação de imagens, considerando as necessidades específicas destes jovens. Destacamos, como resultados, a necessidade de manter uma postura flexível na dinâmica empírica para compreender as demandas dos entrevistados e acolher suas contribuições, sem perder de vista o eixo central da pesquisa, mas permitindo fazer adaptações em um processo reflexivo que deve acontecer não só na análise dos dados, mas também durante sua produção.
Apresentação
Authors: Sartor Basílio , Fragoso Suely
Published: December 2021

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Optimal Multi Zones Search Technique to Detect a Lost Target by Using K Sensors
Authors: El-Hadidy Mohamed , Abou-Gabal Hamdy , Gabr Aya
Published: December 2021

This paper presents the discrete search technique on multi zones to detect a lost target by using  sensors. The search region is divided into  zones. These zones contain an equal number of states (cells) not necessarily identical. Each zone has a one sensor to detect the target. The target moves over the cells according to a random process. We consider the searching effort as a random variable with a known probability distribution. The detection function with the discounted reward function in a certain state  and time interval  are given. The optimal effort distribution that minimizes the probability of undetection is obtained after solving a discrete stochastic optimization problem. An algorithm is constructed to obtain the optimal solution as in the numerical application.
THE EFFECT OF DRUGS OF VARIOUS PHARMACOLOGICAL GROUPS ON THE RESPIROMETRIC FUNCTION OF MITOCHONDRIA IN CONDITIONS OF CHRONIC TRAUMATIC ENCEPHALOPATHY
Authors: Miroshnichenko K. A , Chernikov M. V.
Published: December 2021

Chronic traumatic encephalopathy (CTE) is a severe neurodegenerative pathology that develops as a result of repeated concussions of the brain, leading to disability and death of the patient. Materials and methods. Pathology modeling was carried out by traumatic impact on the parietal region of the rat skull with a weight of 150 g from a height of 50 cm for 7 days. The studied compounds were choline alfoscerate, hopanthenic acid, aminophenylbutyric acid, citrulline malate, and sodium polydihydroxyphenylenethiosulfonate. Results. Significantly significant normalization of mitochondrial respirometric function was found in the conditions of CTE. Conclusions.After analyzing the results, we can assume the presence of a cerebroprotective effect in these drugs by restoring the respirometric function of the mitochondria of brain cells.
ON THE QUESTION OF MODERN DIAGNOSIS OF UREMIC PANCREATITIS AND DESTRUCTIVE PANCREATITIS IN PATIENTS ON RENAL REPLACEMENT THERAPY (PROGRAM HEMODIALYSIS)
Authors: Zurnadzh'yante V. A , Kchibekov E. A , Gasanov K. G
Published: December 2021

The study included 52 patients with suspected pancreatitis who were admitted to the hospital on an emergency basis, who receive renal replacement therapy (programmed hemodialysis) in history. The control group included 50 outpatients on programmed hemodialysis. The study did not include patients with suspected pancreatitis who did not receive programmed hemodialysis. The concentration of p2-microglobulin and ferritin in the blood serum was determined in the studied groups. The most statistically high concentration of p2-microglobulin was found in the group of patients with suspected uremic pancreatitis, and the concentration of ferritin is highest in the group of patients with suspected destructive pancreatitis who received a history of renal replacement therapy (programmed hemodialysis). In the control group of outpatients receiving programmed hemodialysis procedures, there were no statistically significant fluctuations in serum concentrations of p2-microglobulin and ferritin.
COMPARATIVE CHARACTERISTICS OF EROSIVE AND ULCERATIVE LESIONS OF THE GASTROINTESTINAL TRACT AND BLEEDING IN PATIENTS WITH CRITICAL ISCHEMIA OF THE LOWER EXTREMITIES WITH AND WITHOUT DIABETES MELLITUS, WHO UNDERWENT ENDOVASCULAR INTERVENTIONS
Authors: Poliantsev A. A , Frolov D. V , Linchenko A. M , Ievlev V. A , Karpenko S. N , Chernovolenko A. A , Kaplunova E. V , Dyachkova Yu. A
Published: December 2021

Aim: Purpose: to compare the incidence of erosive and ulcerative pathology of the gastric and duodenal mucosa, including those complicated by bleeding, in patients with critical ischemia of the lower extremities, type 2 diabetes and without it, who underwent endovasal revascularization. Materials and methods: 155 patients who took part in the study were divided into two groups: the first group (81 people) included patients with diagnosed diabetes mellitus, the second (74 people) - patients without pancreatic endocrine pathology. Before endovascular surgery, all patients underwent fibrogastroduodenoscopy with ranking according to points of the severity of lesions of the gastroduodenal zone. In the postoperative period, during dynamic observation, the state of the upper gastrointestinal tract was assessed for a year. Results: all patients in both groups were diagnosed with pathological changes in the proximal parts of the gastrointestinal tract from inflammatory-erosive to ulcerative, including those complicated by bleeding. When comparing the severity of changes in groups, statistically significant differences were not obtained. Gastrointestinal bleeding occurred much more frequently in the postoperative period in reoperated patients with diabetes mellitus. Conclusions: due to the wide prevalence of pathology of the gastric and duodenal mucosa, all patients with critical ischemia need to undergo a histological examination, testing for Helicobacter pylori and the appointment of etiopathogenetic treatment or prolonged prevention of bleeding in risk groups.
MORPHOLOGICAL PORTRAIT OF THE CORPUS CALLOSUM OF A PERSON IN OLD AGE, ESTABLISHED ON THE BASIS OF MAGNETIC RESONANCE IMAGING AND HISTOLOGICAL METHODS OF RESEARCH
Authors: Balandin A. A , Zheleznov L. M , Balandina I. A
Published: December 2021

The analysis of the results of morphometric examination of the corpus callosum of 50 people who underwent brain examination in the Department of radiation diagnostics in the period 2019-2020 was carried out. The subjects agreed to a magnetic resonance imaging study, which was conducted only according to indications. The height and length of the corpus callosum, the thickness of the roller and knee, as well as the depth of its occurrence - anterior, upper, and posterior-were determined. A morphological study of the corpus callosum of 23 male and 21 female corpses was carried out on the sectional material. Histological and micrometric methods were used. All the subjects had no history of diseases and injuries of the central and peripheral nervous system, as well as alcohol and drug addiction. The total diameter of microgliocytes was determined. The parameters of the corpus callosum in individuals older established using magnetic resonance imaging did not reflect statistically significant evidence of a sexual dimorphism, while there is a trend to their prevalence in men compared to women. The total diameter of microgliosis in the cushion in the knee of the corpus callosum person in the elderly are characterized by the absence of statistically significant differences of the parameters, however, the tendency to the predominance of settings under the cushion. Both in the knee area and in the area of the corpus callosum roller, there is a tendency to prevail in the indicators of the total diameter of microgliocytes in men in comparison with women.
DETERMINATION OF SOME PHENOLIC COMPOUNDS IN THE EXTRACT FROM THE HERB OF INULA BRITANNICA L BY HPLC
Authors: Ryabukha A. F , Abramov O. K , Smirnova L. A , Yanitskaya A. V , Arutyunova V. V
Published: December 2021

Phenolic compounds are an extensive group of biologically active substances, characterized by a wide range of pharmacological activity. As you know, the chemical composition of plant objects is diverse, but it is in the aboveground part that phenolic compounds predominate. Of particular interest are flavonoids and phenylpropanoids. The identification of compounds of these groups was carried out by HPLC analysis in the grass of inula britannica collected in the Volgograd region. The paper presents chromatograms of water-alcohol extracts with ultraviolet and fluorescent detections, the presence of some hydroxycinnamic acids, namely chlorogenic, caffeic and ferulic acids, as well as luteolin-7-o-glucoside and quercetin from the group of flavonoids.
ENDOTHELIAL DYSFUNCTION IN SURGERY OF AORTO-FEMORO-POPLENOUS SEGMENTS OF ATHEROSCLEROTIC GENESIS
Authors: Lazarenko V. A , Bobrovskaya E. A , Petrova A. A
Published: December 2021

The features of endothelial functional activity in patients with obliterating atherosclerosis with lesions of the femoral-popliteal (n = 140) and aorto-femoral (n = 97) segments before and after reconstructive interventions were studied. Endothelial status was assessed in systemic and local blood flow. There were no differences depending on the level of lesion in the content of homocysteine and the adhesive form of endothelial dysfunction. In the case of proximal lesions observed significantly high levels in systemic and local blood flow oxidized LDL and annexin V, and PAI-1 in systemic blood, with the distal - lower t-PA in the system (of 15,8 %, p = 0,013) and local (32,6 %, p = 0,0005) the bloodstream). There was an increase in prothrombotic potential during distal arterial reconstructions in the systemic blood flow (7,7 %, p = 0,009) and revascularized segment (26,5 %, p < 0,001) and an increase in apoptosis in the operated limb (17,6 %, p = 0,03) compared to proximal reconstructions.
APPLICATION OF PHOTO-OPTICAL METHOD IN THE DIAGNOSIS OF VITREOUS OPACITIES
Authors: Khzardzhan Yu. Yu , Fokin V. P , Balalin A. S , Balalin S. V
Published: December 2021

A photo-optical method has been developed to detect the vitreous body opacities in patients, which is used to estimate the opacities area, to determine the dimming intensity index and retinal dimming factor. Studies were performed in 318 patients (318 eyes) with vitreous opacities. The sensitivity of the photo-optical method in detecting vitreous opacities in patients was 100 %, in contrast to that color photography has 76,4 %. The photo-optical method can also be used to assess effectiveness of YAG-laser vitreolysis to achieve the best clinical results.
ASSESSMENT OF THE RELATIONSHIP OF MENTAL ABILITIES AND FINE MOTOR SKILLS WITH ORAL HYGIENE IN SCHOOL-AGE CHILDREN
Authors: Tikhonov V. E , Faustova A. G , Kalinovsky S. I , Mitina E. N , Ilyasova N. V , Yudakova Yu. S
Published: December 2021

The aim of the study was to investigate the relationship between hand-eye coordination, the general level of intellectual abilities and fine motor skills with oral hygiene in school-age children. Two age groups of schoolchildren, 7-9 years old and 10-12 years old, were selected for the study. For children aged 7-9 years old, it was proposed to pass L. Bender's visual-motor gestalt test and Torrance's creativity test. For children 10-12 years old - a short orientation test and Torrance's creativity test. After testing, the oral hygiene index OHI-S was determined using indicator tablets. According to the test results, the following data were obtained. In children aged 7-9 years, L. Bender's visual-motor gestalt test showed values from 13-45 points, Torrance's creativity test - 26-96 points. In children aged 10-12 years, a short orientation test showed values of 4-17 points, Torrance's creativity test - 28-99 points. For further work with the data obtained, three groups were identified in each test: with high, medium, and low mental abilities. In each of the groups obtained, the average values of the level of hygiene were determined. The study found that low hygiene index scores correspond to those students whose test results for mental ability and fine motor skills are high, and vice versa, high hygiene index scores correspond to those children whose test scores are low. Thus, the level of oral hygiene is directly related to mental performance and fine motor skills in children.
COMPARATIVE CHARACTERISTICS OF SENSORIMOTOR REACTIONS IN THE TASKS OF VISUAL SEARCH IN STUDENTS OF VARIOUS AGE GROUPS
Authors: Astashchenko A. P , Tyunina O. I , Bayeva Ye. S , Dorokhov Ye. V , Gorbatenko N. P , Komissarova O. V
Published: December 2021

The formation of perception and voluntary attention functions is the basis for the development of the child's cognitive activity. The implementation features of the voluntary attention processes on the models of simple and complex visual search in groups of subjects with an age range from 8 to 18 years old were studied. Reaction time, errors (goal's omissions, false alarms), time for cognitive processes, correlations and features of attention efficiency in subjects with various academic performances were analyzed. The search time for a single element in a random location of an empty grid decreases with age. Errors such as "false alarm" prevail in younger age groups. The effectiveness of visual search can be one of the criteria for academic performance. Young men and women with low academic performance make significantly more mistakes such as "false alarm" in visual search tasks. The front-parietal attention system is the main one for the implementation of sensorimotor reactions. The maturation of this system can be the basis for increasing the attention effectiveness with age.
HIGHER BRAIN FUNCTIONS OF PRESCHOOLERS WITH SPEECH DISORDERS
Authors: Slapovskaya O. I , Komarov A. U , Patyukov A. G , Rusakov V. V
Published: December 2021

Speech disorders are quite common in preschool age and provoke violations not only of verbal, but also of personal and social relationships. In children with speech disorders, depending on the duration of the visit to the speech kindergarten, the function of speech, praxis, gnosis, memory, attention, and thinking were studied using test tasks. It is established that children who attend speech kindergarten for the first year, as well as children who stay in this institution for the second year, have some features in the state of praxis and mnestic functions. Against the background of correctional measures, the majority of children aged 6-7 years (by the third year of attending a speech kindergarten) have a state of higher brain functions that practically does not differ from their peers from a mass kindergarten.
FATIGUE SYMPTOMS UNDER LOCAL EXERCISE IN ATHLETES AGED 17-22 YEARS
Authors: Popova T. V , Koryukalov Yu. I , Korableva Yu. B
Published: December 2021

The paper aims to identify functional features of hand muscles under local exercise to fatigue in acyclic sports. Materials and methods. University students from acyclic sports, where the largest load is distributed between the extremities, abdominal and back muscles, participated in the experiment.The control group involved non-athletes of the same age and gender. The subjects were tested on a finger ergograph or hand dynamometer (lifting an average weight to fatigue or holding a weight of 1/3 of submaximal at a given height). EEG data were recorded and work capacity was calculated under exercise. The results of the study showed that hand performance in athletes was higher than that of non-athletes. EEG differences were found in terms of fatigue symptoms, especially in slow-wave theta and alpha activity. The conclusionwas drawn on the use of local exercise for a comprehensive assessment of physical fitness.
La evolución de las diferencias en función del género en la educación universitaria y la inserción en el mercado laboral en España desde los años setenta a la actualidad
Authors: Philipp Rita Radl , Vázquez Maria Begoña Gómez
Published: December 2021

De todos los fenómenos de cambio social acaecidos en España en los últimos tiempos dos han sido especialmente relevantes, por una parte, la destacable elevación del nivel educativo de la población que ha derivado en modificaciones en los niveles de actividad y empleo al modificarse el nivel formativo de la población en edad de trabajar, y por otro, el creciente acceso de las mujeres al mercado laboral y su permanencia en éste. Estos dos fenómenos han sido singularmente intensos en lo que se refiere a las mujeres y a la educación superior, siendo este colectivo el que ha protagonizado una más fuerte incorporación al mercado de trabajo en comparación con épocas anteriores de la historia reciente. Sin embargo, los indicadores laborales evidencian, aún hoy en día, desigualdades en función del género entre la población con educación superior. Investigamos el transcurso de la evolución de las diferencias en función del género en cuanto a la formación universitaria y su consiguiente correlación con la inserción de las mujeres en el mercado laboral a lo largo de los últimos cinco decenios, centrándonos en algunos indicadores de la desigualdad en función del género. Argumentaremos desde un enfoque epistemológico de las mujeres, feminista y de género la tesis que el factor género actúa como un elemento manifiesto de discriminación más allá del proprio valor educativo y formativo del capital humano.
RELIGIOUS EDUCATION AND ADOLESCENT RELIGIOSITY (Part 1: Urban and Rural Madrasah Aliyah Characteristics in Lombok Island)
Authors: Mareta Mira
Published: December 2021

The current social circumstances at the spiritual level have brought an enormous influence on the establishment of religious behavior in adolescent students, both in the level of belief, practice, and religious experience. Religious education in the madrasah environment has a strategic position in building students' religious behavior. This study aims to explain why the rural and urban madrasah environment context is essential to observe the role of religious education, especially Islamic education, in building students' religious behavior in Lombok island. Then it sorts out the madrasahs characteristics or uniqueness from the two different regions, rural and urban. This research is qualitative psychological research with ecological contextual theory as the theoretical framework. The data analysis method is descriptive and holistic by employing three flows of interacting activities, e.g., reducing data, presenting it, and drawing conclusions. Data was obtained through documentation, observation, and in-depth interviews. This research was conducted in six madrasahs, i.e., two Madrasah Aliyah located in the downtown, and four Madrasah Aliyah, which geographically represent the category of the rural madrasah. The research results indicate that the spiritual development of the students cannot be separated from the religious education context in their environment. In urban areas context, the madrasah environment has formal systemic characteristics, is supported by strong management and leadership, maintains the madrasah stability and conduciveness by implementing a power strategy through a set of rules and code of conduct. Meanwhile, madrasas in rural areas have flexible, dynamic, and adaptive characteristics, in which education takes into account cultural aspects and values applied in the community.
STUDI BIOINFORMASI URUTAN ASAM AMINO DAN STRUKTUR 3D PROTEIN ALDOLASE KELAS II (AldII) DARI Uncultured Acidilobus sp.
Authors: Meray Nishia Waya , Suharti Suharti , Akhmaloka Akhmaloka
Published: December 2021

Pada penelitian sebelumnya fragmen gen 1,9 kb telah berhasil diisolasi dari Kawah Domas, Jawa Barat melalui pendekatan metagenom. Fragmen tersebut diketahui mengandung daerah Open Reading Frame (ORF) utuh dari gen pengkode aldolase kelas II dari uncultured Acidilobus sp. yang kemudian disebut sebagai aldII. Fragmen gen aldII tersebut berhasil diekspresikan menjadi protein termostabil aldolase kelas II yang kemudian disebut sebagai AldII. Penelitian ini bertujuan untuk melakukan studi bioinformasi terhadap protein AldII tersebut. Protein AldII kemudian diketahui memiliki massa molekul ~21,2 kDa dengan rumus molekul C940H1539N261O281S8. Total residu bermuatan negatif (Asp + Glu) sebanyak 22 residu, sedangkan total residu bermuatan positif (Arg + Lys) adalah 18 residu. Nilai pI teoritis AldII sebesar 5,86. Hasil perhitungan indeks kestabilan protein ini adalah 36,61 dan diklasifikasikan sebagai protein yang stabil. Lewat penjajaran dengan homologi terdekat, ditemukan daerah lestari yang dapat menunjukan residu yang mungkin berperan dalam pengikatan logam dan sisi aktif. Prediksi struktur 3D dilakukan secara ab initio, menunjukan adanya 6 struktur β-sheet dan 6 struktur α-heliks. Dengan demikian dapat disimpulkan bahwa protein AldII dari uncultured Acidilobus sp. diduga memiliki aktivitas enzimatik.
Clinicoradiographic predictors of progression of an intermediate hepatic lesion (LI-RADS 3) to hepatocellular carcinoma (LI-RADS 5)
Authors: Hannan Lindsay M. , Ojeda Patricia I. , Mieloszyk Rebecca J. , Harris William P. , Park James O. , Bhargava Puneet
Published: December 2021

Aim: We sought to identify predictors of progression of an indeterminate observation (LI-RADS 3) to hepatocellular carcinoma (LI-RADS 5). Methods: Imaging reports with LI-RADS (LR) assignments were identified among patients at the University of Washington, 2013-2017. Patients with an LR3 lesion and follow-up scan within 1 year of LR3 lesion date were included (n = 313). Features of interest were abstracted from chart review. Survival analyses employing interval censoring were performed, with variables potentially predictive of LR3 progression identified in univariate analyses. Backwards elimination (P < 0.05) was used to obtain the final multivariate model. Results: 20.4% of LR3 lesions progressed to LR5; 73% remained LR3, 8% LR4. The cohort was predominantly male (61%), Caucasian (54%), older than 55 (63%). 47% had a history of hepatitis C virus (HCV), 33% with alcohol abuse, not mutually exclusive. Alpha-fetoprotein (AFP) at the time of LR3 scan was low if available (39% with AFP < 5, 29% unknown). CT was the most common exam (56%). Men (HR = 2.0, P = 0.02), earlier scan year (HR = 0.47 per year, P < 0.0001), and older age (HR = 1.48, P = 0.03), appeared as predictors of LR progression in the final model. HCV and alcohol use were more common among men but did not appear to explain the difference in LR progression by sex. Conclusion: Our analysis is an early exploration of characteristics that may predict the risk of progression of an LR3 observation to hepatocellular carcinoma. Future efforts may allow for risk stratification to identify high-risk indeterminate lesions that may benefit from earlier intervention or more frequent surveillance.
Using cfRNA as a tool to evaluate clinical treatment outcomes in patients with metastatic lung cancers and other tumors
Authors: Raez Luis E. , Danenberg Kathleen , Sumarriva Daniel , Usher Joshua , Sands Jacob , Castrellon Aurelio , Ferraro Pablo , Milillo Adriana , Huang Eric , Soon-Shiong Patrick , Reddy Sandeep , Danenberg Peter
Published: December 2021

Aim: We report an exploratory analysis of cfRNA as a biomarker to monitor clinical responses in non-small cell lung cancer (NSCLC), breast cancer, and colorectal cancer (CRC). An analysis of cfRNA as a method for measuring PD-L1 expression with comparison to clinical responses was also performed in the NSCLC cohort. Methods: Blood samples were collected from 127 patients with metastatic disease that were undergoing therapy, 52 with NSCLC, 50 with breast cancer, and 25 with CRC. cfRNA was purified from fractionated plasma, and following reverse transcription (RT), total cfRNA and gene expression of PD-L1were analyzed by real-time polymerase chain reaction (qPCR) using beta-actin expression as a surrogate for relative amounts of cfDNA and cfRNA. For the concordance study of liquid biopsies and tissue biopsies, the isolated RNA was analyzed by RNAseq for the expressions of 13 genes. We had to close the study early due to a lack of follow-up during the Covid-19 pandemic. Results: We collected a total of 373 blood samples. Mean cfRNA PCR signals after RT were about 50-fold higher than those of cfDNA. cfRNA was detected in all patients, while cfDNA was detected in 88% of them. A high concordance was found for the expression levels of 13 genes between blood and solid tumor tissue. Changes in cfRNA levels followed over the course of treatments were associated with response to therapy, increasing in progressive disease (PD) and falling when a partial response (PR) occurred. The expression of PD-L1 over time in patients treated with immunotherapy decreased with PR but increased with PD. Pre-treatment levels of PD-L1 were predictive of response in patients treated with immunotherapy. Conclusion: Changes in cfRNA correlate with clinical response to the therapy. Total cfRNA may be useful in predicting clinical outcomes. PD-L1 gene expression may provide a biomarker to predict response to PD-L1 inhibition.
ANALISIS BIAYA PENYULINGAN MINYAK GAHARU BUDIDAYA DI TENGGARONG, KALIMANTAN TIMUR
Authors: Wahyuni Tien , Yuliana Helsa
Published: December 2021

Salah satu usaha untuk meningkatkan nilai tambah gaharu mutu rendah (medang, sapuan, sabak) dengan penyulingan untuk menghasilkan minyak. Minyak gaharu dimanfaatkan sebagai bahan baku beberapa produk seperti bahan baku parfum, kosmetik, dan obat-obatan tradisional. Penelitian penyulingan gaharu ini bertujuan untuk mengetahui rendemen minyak, produk sampingan, menganalisis biaya, pendapatan dan keuntungan maksimum selama satu periode penyulingan pada industri penyulingan skala rumah tangga. Penelitian dilaksanakan di industri penyulingan minyak gaharu berskala rumah tangga yang terletak di Kelurahan Rempanga, Kecamatan Loa Kulu Tenggarong, Kabupaten Kutai Kartanegara Provinsi Kalimantan Timur. Hasil penelitian diharapkan dapat memberikan motivasi kepada berbagai pihak untuk dapat memanfaatkan kayu gaharu hasil budi daya berkualitas rendah seefisien dan semaksimal mungkin melalui diversifikasi produk dengan cara penyulingan untuk menghasilkan minyak gaharu bernilai tinggi. Prosedur pengamatan dilakukan secara langsung selama proses penyulingan. Nilai ekonomi diperoleh dengan menganalisis titik impas (BEP) dan pendapatan maksimum. Hasil penelitian menghasilkan rendemen minyak gaharu sebesar 0,07%. Pada tingkat produksi minyak gaharu sebanyak 30 mililiter (ml) per satu periode produksi dengan harga jual Rp 250.000/mL akan mencapai titik impas jika minyak gaharu yang dihasilkan sebanyak 1,93 ml dengan nilai sebesar Rp 482.159,88 atau Rp 16.071,99/ml (unit). Keuntungan usaha pada tingkat produksi 30 ml minyak gaharu sebesar Rp 3.616.830 (tanpa penjualan ampas serbuk dan hidrosol gaharu) dan sebesar Rp 8.316.830 (dengan penjualan ampas serbuk dan hidrosol gaharu).
IMPROVEMENT ON SEVERAL PHYSICAL AND MECHANICAL PROPERTIES OF JATI UTAMA NUSANTARA WOOD BY THERMAL COMPRESSION TREATMENT
Authors: Basri Efrida , Saefudin Saefudin
Published: December 2021

Jati Utama Nusantara (JUN) adalah salah satu tipe jati (Tectona grandis Linn. F) cepat tumbuh yang berasal dari Jati Plus Perhutani (JPP). Pohon JUN memiliki sedikit percabangan dan batang yang lebih berbentuk silinder serta menunjukkan pertumbuhan yang lebih cepat dibandingkan jati budidaya dari biji (konvensional), sehingga dapat dipanen dalam waktu singkat. Meskipun cepat tumbuh, berbagai penelitian menunjukkan kayu JUN belum memenuhi standar SNI 01-0608 sebagai bahan baku furnitur. Penelitian ini bertujuan untuk meningkatkan beberapa sifat fisis dan mekanis kayu JUN umur muda melalui perlakuan pemadatan menggunakan kempa panas. Contoh uji kayu JUN umur 5 tahun berukuran 2,5 cm (tebal/radial), 10 cm (lebar/tangensial), dan 30 cm (panjang/longitudinal) diberi tekanan sebesar 25 kg/cm2 selama 40 menit dengan 3 perlakuan suhu, yaitu 170°C, 180°C, dan 190°C. Pengujian sifat fisis dan mekanis kayu mengacu pada standar ASTM D143. Perubahan kristalinitas kayu diamati menggunakan X-ray Diffractometer (XRD), dan permukaan kayu diamati secara visual. Sebagai penunjang, pengamatan struktur sel kayu dilakukan menggunakan mikroskop stereo (Zeiss). Hasil penelitian menunjukkan bahwa contoh uji kayu JUN yang diberi perlakuan tekan-panas dapat memperbaiki sifat fisis dan mekanisnya dibandingkan contoh uji kayu JUN tanpa perlakuan (kontrol). Berdasarkan hasil simulasi data, sifat fisis dan mekanis contoh uji terbaik diperoleh pada suhu kempa sekitar 185°C.
STUDI EKSTRAK n-HEKSANA DARI KULIT BATANG KANDIS HUTAN (Garcinia cymosa)
Authors: Darwati Darwati , Nurlelasari Nurlelasari , Mayanti Tri , Supratman Unang
Published: December 2021

Tanaman dari Garcinia (Famili Guttiferae) yang tumbuh di hutan tropis Indonesia memiliki potensi kandungan senyawa triterpenoid. Garcinia cymosa telah dilaporkan memiliki potensi sebagai sumber utama senyawa triterpenoid yang memiliki aktivitas biologis yang bermanfaat, seperti anti-inflamasi, antibakteri, antijamur, anti-oksidan, sitotoksik, dan anti-HIV. Saat ini data dan informasi mengenai senyawa triterpenoid yang terkandung di dalam G. cymosa relatif masih sangat sedikit. Tulisan ini mempelajari senyawa triterpenoid dari kulit batang G. cymosa. Kulit batang G. cymosa dimaserasi dengan menggunakan pelarut n-heksana yang kemudian dipisahkan dan dimurnikan dengan metode kromatografi hingga diperoleh isolat murni berupa kristal jarum putih (10,8 mg). Struktur kimia isolat murni ditentukan dengan metode spektroskopi IR, 1D-NMR, 2D-NMR dan spektroskopi massa serta dilakukan perbandingan dengan literatur. Hasil penelitian menunjukkan senyawa friedelin berhasildiisolasi dari n-heksana kulit batang G. cymosa. Senyawa yang telah diisolasi teridentifikasi sebagai senyawa friedelin.