bluuebunny/crossref_metadata_2025 huggingface dataset:
"Streaming Noir": la evolución del thriller en las series españolas
Authors: Cañas Pelayo Marcos Rafael
Published: January 2025

A lo largo de las últimas décadas, el cine negro español ha ido evolucionando desde un cierto manierismo para emular a los thrillers norteamericanos hasta unos productos más autóctonos que, sin renunciar a la calidad en la factura de los mismos, tratan temas sociales más próximos a la audiencia. Paralelamente y como un efecto colateral de sumo interés, ello ha beneficiado sobremanera a las ficciones televisivas, las cuales han tomado esa fuente de inspiración con la ventaja de disponer de más horas para desarrollar a sus personajes y sus motivaciones que en el celuloide. Por ejemplo, el punto de inflexión que supuso la situación pandémica para el auge de las plataformas de streaming derivó en una verdadera proliferación de series nacionales (Nasdrovia, Patria, Antidisturbios, etc.) que aspiraban a culminar una revolución que ya se había ido gestando en los años anteriores. Nuestro análisis busca plantear una cronología para comprender mejor este fenómeno televisivo y, de igual manera, incidir en los contextos históricos e investigaciones periodísticas (en particular casos como Fariña de Nacho Carretero) que han justificado ese interés del público, fiel reflejo de las preocupaciones y temas de la más rabiosa actualidad (corrupción política, terrorismo, crimen organizado, etc.) del país.
Intriga, Franquismo y misterio en la Barcelona de los años 80. La serie Recordar, peligro de muerte / Recordar, perill de mort
Authors: Jiménez González Xavier
Published: January 2025

El artículo presenta un estudio monográfico sobre la serie Recordar, peligro de muerte (Montanyés, 1985), estructurado en torno a dos cuestiones principales. En primer lugar, se aborda el análisis del lugar que ocupa dentro de la historia de las ficciones producidas por Radiotelevisión Española en la década de 1980; por otro lado, se reivindica su valor en cuanto a su compromiso político, centrado en la denuncia de la represión franquista como eje narrativo. La primera parte del estudio busca situar la serie dentro de las diversas taxonomías de producciones televisivas surgidas a partir de 1980, mientras que la segunda plantea un enfoque sobre su relevancia al exponer una de las consecuencias directas de la dictadura, un tema inédito en las tramas de ficción de la época. Finalmente, se destaca un tercer objetivo: recuperar, reivindicar y visibilizar un título que ha sido sistemáticamente olvidado en los estudios sobre la historia de las series de Televisión Española publicados en los últimos cuarenta años.
La URSS y el Bloque del Este a través del NO-DO (1943-1975)
Authors: Roig Daniel
Published: January 2025

Este artículo analiza el tratamiento informativo que realizó el NO-DO sobre la URSS y el llamado Bloque del Este, desde su aparición como noticiario, el 4 de enero de 1943, hasta el final del franquismo en 1975. Con ello, también se pretende destacar cuáles fueron los elementos principales que caracterizarían a la propaganda franquista durante la Guerra Fría, y cómo evolucionaría su retórica anticomunista respecto a las democracias populares de la Europa centro-oriental a través de su noticiario oficial. Por consiguiente, el presente texto parte de la revisión y evaluación de las más de 600 noticias localizadas a lo largo del periodo estudiado, no solo en las diferentes ediciones semanales del noticiario, sino también mediante algunos de los productos audiovisuales más importantes que produciría el NO-DO: Documentales Blanco/Negro (1943-1977), Revista Imágenes (1945-1968) y Documentales Color (1954-1981). En suma, un compendio de fuentes primarias audiovisuales que también muestran cómo los contenidos del NO-DO fueron, en realidad, un reflejo parcial y sesgado de las relaciones entre la España franquista y los países del Bloque del Este.
Understanding Groundwater Resource Vulnerability at Bryce Canyon National Park, Utah, Using Applied Geophysics at the Rubys Inn Thrust Fault
Authors: Schlossnagle Trevor H. , Smith Kayla D. , Gilkerson Tyler C.
Published: January 2025

Recent development near Bryce Canyon National Park, Utah, could affect local groundwater usage, availability, and dependent resources. The National Park Service and Utah Geological Survey conducted a geophysical study targeting the Rubys Inn thrust fault. This fault lies between commonly targeted aquifers in Emery Valley and groundwater flow systems of the Paunsaugunt Plateau, which support springs and dependent ecosystems. Fault zone geometry and internal structure are complex, resulting in a heterogeneous permeability distribution that affects groundwater flow. The influence of fault zones on groundwater flow parallel and perpendicular to their planes is difficult to predict. Geophysical imaging can yield important information about subsurface fault geometry. We utilized electrical resistivity tomography (ERT) surveys to investigate the influence of the Rubys Inn fault on groundwater occurrence and movement along the southeast boundary of Emery Valley. We collected ERT data along three transects orthogonal to the mapped fault strike in May and September 2022. Where available, we used water-level and lithologic data to constrain ERT inversion model interpretations. The inversion models illustrate the complexity and variability of the Rubys Inn fault within a short distance along strike. Where the fault is concealed, results indicate that the actual and mapped locations differ by 70–100 m along the transects. Groundwater is well constrained in the hanging wall, but poorly constrained in the footwall, and some seasonal variation is discernible. Variable stratigraphy and structure are apparent in all transects. This study enables strategic placement of test wells that will further establish the influence of the Rubys Inn fault on the occurrence and movement of groundwater in and adjacent to the fault zone. The study demonstrates that ERT is a cost-effective and noninvasive tool for detecting the precise surface location and delineating subsurface fault geometry in otherwise data-poor areas with sensitive ecological or archaeological resources.
Comparación de la efectividad del uso de la inmunoglobulina endovenosa frente a plasmaféresis en el tratamiento de miastenia gravis juvenil en el Hospital Edgardo Rebagliati Martins durante el periodo 2007-2022
Authors:   , Huanca Esquiagola Stephanie Marcela
Published: January 2025

Objetivo: Comparar la efectividad de inmunoglobulina endovenosa frente a la plasmaféresis como tratamiento de miastenia gravis juvenil en el “Hospital Edgardo Rebagliati Martins” (HNERM) durante el período 2007-2022.
Pregunta de investigación: ¿Es más efectivo el uso de inmunoglobulina endovenosa frente a plasmaféresis, en el tratamiento de miastenia gravis juvenil en el “Hospital Edgardo Rebagliati Martins” durante el periodo comprendido entre el 2007 al 2022?
Metodología: Estudio retrospectivo, observacional y de tipo cohorte, que será realizado durante el mes de Julio del 2024 en pacientes con miastenia gravis juvenil del “Hospital Edgardo Rebagliati Martins”. Se revisarán las historias clínicas de pacientes con edades que estén comprendidas entre los 0 a 14 años.
Técnicas de cocción al vapor, hervido y por microondas, sobre la capacidad antioxidante y compuestos bioactivos de 3 variedades de papas nativas coloreadas (Solanum tuberosum L)
Authors:   , Guerra Barriga Nebai Esther
Published: January 2025

El propósito del presente estudio de tesis consistió en investigar el efecto de las técnicas de cocción; al vapor, hervida y por microondas, sobre los compuestos bioactivos y la actividad antioxidante de 3 variedades de papas coloreadas, Puka Soncco, Leona y Pumapa Maquin. Estudiamos las papas de manera integral, pulpa y cáscara, mediante el método de reducción Férrica FRAP y la determinación del contenido de Polifenoles Totales y Flavonoides. Este estudio ha permitido concluir que las técnicas de cocción favorecen la solubilidad de polifenoles y flavonoides y que el contenido de estas se correlaciona muy bien con la capacidad antioxidante. También concluimos que las variedades más coloreadas tienen mayor capacidad oxidante. Los análisis han sido realizados en el laboratorio de Bromatología de la Universidad científica del Sur.
Aplicativo web basado en la geolocalización para el control de alquiler de equipos industriales
Authors:   , Fuentes Rivera Giron Silvia Jaqueline , Chavez Estrella Lesly Karen
Published: January 2025

En los últimos años, las empresas dedicadas al rubro de alquiler de equipos industriales han sufrido problemas, como el tiempo excesivo que toma el proceso de búsqueda de los equipos alquilados o la pérdida de estos. Este artículo tiene como objetivo el desarrollo de un aplicativo web para el control de alquiler de equipos industriales a través de la geolocalización. El estudio se califica como una investigación experimental, teniendo un enfoque cuantitativo y un alcance descriptivo experimental.

En resumen, este artículo aporta al avance del conocimiento en ámbitos de la geolocalización de equipos industriales, ofreciendo una visión integral de las tecnologías existentes (hardware y software). Sus hallazgos tienen el potencial de informar y guiar la implementación efectiva de sistemas de geolocalización en entornos industriales, impulsando la mejora continua de procesos y operaciones.

En conclusión, el aplicativo web se desarrolló y ejecutó, logrando mejorar el control de equipos industriales, mejorando los tiempos de búsqueda de los equipos, ubicándolos a través de la latitud y longitud y, sobre todo, llegando a mostrar un reporte de los datos de ubicación, lo cual se puede enviar al cliente, mejorando así la calidad de servicio.
Disrupted and Rebuilt: The Untold Impact of City Network Restructuring on China’s Post-Lockdown Recovery
Authors: Sun Zhen , Rong Ke , Lv Ruoming , Tian Xiaoxuan , Li Hongjun , Xie Danxia , Liao Kaicheng , Wang Jiexin
Published: January 2025

Following the end of the zero-COVID policy, China’s economic recovery elicited high hopes but turned out to be disappointing in 2023. This paper provides a novel explanation for the slow economic recovery based on city network disruption and restructuring after major shocks. The supply-demand connections, once disrupted by lockdowns, could not revert to their pre-lockdown state after reopening. Instead, they underwent further restructuring, incurring considerable transaction costs. Using a unique dataset of 1,004,818 heavy trucks with over 600 million inter-city origin-destination records, we find that although freight workload started to grow following the lifting of lockdown measures, it remained below pre-lockdown levels even seven months after reopening. The observed recovery pattern is primarily driven by a surge in short-distance travel, contrasting with a decline in long-distance travel. We show that this shift signifies a restructuring process of connections within the city network, which takes time to materialize and might lack logistics efficiency. Moreover, this restructuring has reshaped the landscape of China’s economic geography. It strengthened the economic connections within city clusters while weakening those between them. Conventional economic growth poles and coastal cities experienced a sluggish recovery, whereas certain inland cities emerged as primary beneficiaries of the network restructuring. Finally, we provide empirical evidence that the city network restructuring is associated with previous disruptions induced by lockdowns. Our analysis offers new insights into the recovery dynamics of economies post major economic shocks from the perspective of city networks.
A comparative study on the carbon storage and oxygen release capacity of Swietenia macrophylla king. and Eucalyptus camaldulensis Dehn. in northwest Bangladesh
Authors: Rahman Mohammed Mukhlesur , Rahman Mizanur , Pitol Md. Najmus Sayadat
Published: January 2025

Plantation sequesters atmospheric carbon and produces oxygen through photosynthesis and stores it as a reserve. Estimating the carbon sequestration capacity of forest tree species is essential for implementing massive plantation programs in developing countries such as Bangladesh. The present study was conducted on the carbon storage and release oxygen capacity of Swietenia macrophylla and Eucalyptus camaldulensis which were planted forest tree species in the same ecological condition. Allometric equations were applied to estimate organic carbon in two species of trees. The diameter increased with increasing height and positive correlations were found in S. macrophylla and E. camaldulensis respectively (p < 0.05). The maximum carbon storage of S. macrophylla and E. camaldulensis were 17.24 kg tree− 1 year− 1 and 21.73 kg tree− 1 year− 1 at twenty years old tree respectively. The lowest carbon storage of S. macrophylla and E. camaldulensis were 5.03 and 9.24 kg tree− 1 year− 1 at five years old, respectively. There was no significant difference (df = 11; p = 0.658) found between the DBH of the two species while their DBH were significantly different among their ages (df = 11; p = 0.000). Besides, the height of these two species was significantly difference (df = 11; p = 0.002) but not significant in their ages (df = 11; p = 0.694). The height and DBH growth became slower with the increase of the age of the plantations. The biomass, carbon stock, carbon-di-oxide storage and O2 releasing potentiality were related to each other and significantly differed from their ages (p-value varied from 0.001 to 0.023). Comparatively higher growth performances were observed in E. camaldulensis than S. macrophylla in the same environmental conditions, management and equal ages. The findings indicated that S. macrophylla and E. camaldulensis both can be selected in the massive plantation programs in this area which will contribute to large carbon storage and play a vital role in mitigating climate change.
Energy Burden in Electric Vehicle Grid Integration: A New England Case Study
Authors: Qiu Feng , Xu Jie , Li Siwei , Siddiki Saba , Wang Victor
Published: January 2025

Widespread adoption of electric vehicles (EVs) is hailed as an effective measure for reducing greenhouse gas emissions and fighting climate change. However, increasing charging loads coinciding with greater uptake of EVs will place additional pressure on the current and future electric grid. To better understand the implications of transportation electrification on the electric grid, existing literature has begun to examine the impact of changing EV charging loads on electricity price. However, within these studies, the analysis is often at an aggregated level, both geographically and population wise, and limited attention has been given to con- textualizing electricity price changes locationally and demographically. In response to these limitations, here we conducted an in-depth study of the implications of large-scale EV grid integration using the ISO New England (ISO-NE) network as a case study. Using the regional system planning (RSP) model of ISO-NE, we investigated the changes in wholesale prices in 13 RSP areas in a baseline scenario that represents the current system projected into 2040, and a deep decarbonization scenario set forth in the technical report of Massachusetts 2050 decarbonization roadmap study. We also studied variations based on the deep decarbonization scenario. We then translated the predicted changes in wholesale prices into changes in retail electricity rates at a county level, and examined the impact on for households contained in 2021 American Community Survey data. Results suggest substantial seasonal and geographical differences in locational marginal prices (LMPs) in ISO-NE network. While our results show that the projected production resources and transmission capacity in 2040 are generally sufficient to support the EV adoption goal, further increase in EV adoptions may create significant increase in electricity prices that have substantial locational and demographic variations. Finally, we summarized the differences in the energy burdens on differ- ent demographic groups created by the projected increase in LMPs and subsequent increases in retail rates at county level.
Efficacy and safety of stem cell therapy in patients with Diabetes Mellitus – A Systematic Review and Meta-analysis
Authors: Manikandan Srinivasan , Hariprasad Roopa , Bagepally Bhavani Shankara
Published: January 2025

Background
To support the development of a national guideline on stem cell therapy, the Department of Health Research, India, commissioned this systematic review to evaluate the efficacy and safety of various stem cell types in patients with type 1 and type 2 diabetes mellitus (DM), focusing on patient-important outcomes.
Methods
Following PRISMA guidelines, a literature search was conducted in PubMed, Embase, Web of Science, and Cochrane databases from inception to August 30, 2024. Critical outcomes for type 1 DM included insulin-free periods, hypoglycemic episodes, quality of life, and serious adverse events. For type 2 DM, outcomes included HbA1c, insulin requirements at 6, 12, and 24 months, and serious adverse events. Meta-analyses used random- or fixed-effects models based on heterogeneity (Chi-square test and I²). Risk of bias was assessed using Cochrane Risk of Bias Tool 2.0, and evidence certainty was evaluated with GRADE.
Results
The search identified 11,026 articles, of which 20 randomized controlled trials (RCTs) were included, encompassing 427 and 351 patients in the intervention and control groups, respectively, with follow-ups ranging from 3 to 96 months. Predominantly studied therapies included mesenchymal and bone marrow mononuclear stem cells. In type 1 DM, stem cell therapy showed no significant improvement in quality of life [MD: 3.15% (95% CI: -0.80 to 7.10), I² = 0%] or reduction in hypoglycemic episodes [RR: 0.90 (95% CI: 0.56 to 1.45), I² = 0%]. In type 2 DM, stem cell therapy significantly reduced insulin requirements at 6, 12, and 24 months, with MDs of -14.42 IU/day (95% CI: -24.25 to -4.59, I² = 91.64%), -17.79 IU/day (95% CI: -26.39 to -9.18, I² = 70.96%), and − 35.73 IU/day (95% CI: -40.82 to -30.64, I² = NA), respectively, with a low certainty of evidence.
Conclusion
Stem cell therapy did not achieve an insulin-free state or improved quality of life in type 1 DM patients. However, it reduced insulin requirements by 14–36 units over 6–24 months in type 2 DM patients, without significant glycemic control. Larger, high-quality RCTs with extended follow-ups are essential to determine the therapeutic potential of stem cell therapy in diabetes mellitus.
PROSPERO ID: CRD42023451602
In Vitro and In Vivo Germination of Novel F1 Hybrid Banana Calcutta 4 × Neypoovan Tetraploid Enhanced by Gibberellin and Indole-3-acetic acid
Authors: - Bhuvaneshwari - , Rex Gilbert Ross , - Ramajayam - , - Sivashankari -
Published: January 2025

This work focuses on rescuing and germinating embryos from F1 hybrid seeds obtained from the cross of Calcutta 4 and Neypoovan tetraploids. The goal was to assess the effects of growth regulators gibberellic acid (GA3) and indole-3-acetic acid (IAA) on seed germination and early seedling development in vitro and in vivo.The seeds were hydro-primed and surface-sterilized for 48 hours before being treated with different concentrations of GA3 (5 and 10 ppm) and IAA (5 and 10 ppm). The seeds were hydro-primed and surface-sterilized for 48 hours before being subjected to various concentrations of GA3 (5 and 10 ppm) and IAA (5 and 10 ppm). Embryo rescue was performed using Murashige and Skoog (MS) media for in vitro germination, with in vivo germination observed for comparison. The results showed that the maximum germination rate (77.78%) and better shoot and root growth were attained under in vitro conditions with GA3 at 5 ppm, with early shoot emergence at 8.40 days and shoot length reaching 6.63 mm. In vivo germination rates, however, were much lower, with just 6.67% germination in seeds treated with GA3 at 5 and 10 ppm and 0% in those treated with IAA. GA3 at 5 ppm was determined to be the best concentration for increasing germination and development of Calcutta 4 x Ney Poovan tetraploid hybrid seeds, especially in vitro.
Severe Central Airway Obstruction Secondary to a Endobronchial Central Airway Obstruction Secondary to Primary B-cell Lymphoma With : three case reports and literature review
Authors: LI Cai-li , ZHOU Wei , CHEN Mo , LI Shuo , CHEN Bao-yuan , WANG Yu-bao , ZHAO Hai-yan , FENG Jing
Published: January 2025

Central airway obstruction can be secondary to extrinsic compression from surrounding structures, direct extension from an adjacent tumor, metastatic disease and, less commonly primary intrinsic endobronchial malignancies.To our knowledge, nearly few reports of an isolated central airway lesion by primary lymphoma without extrathoracic or extra-nodal manifestation have been published to date. This is the first case about malignant trachea obstruction caused by primary B-cell lymphoma without involvement of the main stem bronchi, lobar bronchus and mediastinum. Cases presentation: The three patients were admitted to hospital for coughing accompanied by wheezing that recent exacerbated. The chest computed tomography scan revealed a soft tissue-density mass within the central trachea. Pathological analysis showed that these were lymphoma. No enlarged mediastinal or cervical lymph nodes were found.. Conclusion: A high suspicion of endobronchial lymphoma is warranted in the differential diagnosis of a pathological mass located in central airway.
Does bullying occur in preschool? A survey of French preschool workers’ perceptions and beliefs about bullying
Authors: Martelli Inès , Grand Estelle , Dewandre Antoinette , Habib Marianne , Villemonteix Thomas
Published: January 2025

School bullying constitutes a significant adverse childhood experience for both victims and perpetrators. Teachers and school staff play a pivotal role in identifying and preventing bullying. Although extensively studied among school-aged children, research on bullying in preschool settings remains scarce. This study used quant data to explore the perceptions and beliefs of French preschool staff (N = 191) regarding bullying, focusing on definitional aspects, observed bullying behaviors in preschool environments, the roles of school staff and parents, and beliefs about prevention. The findings reveal that French preschool staff's understanding of bullying definitions diverges somewhat from those commonly found in the scientific literature. Moreover, participants expressed hesitancy in applying the term "bullying" to describe aggressive interactions among preschool-aged children. The results further indicate that professional training for preschool staff could be enhanced to promote more effective interpersonal dynamics within teams. While participants emphasized the importance of implementing prevention programs in French preschools and actively engaging parents, they reported limited implementation of such initiatives. These findings align with existing literature but also highlight unique contextual factors shaped by French educational policies and anti-bullying legislation.
Insights into the Formation of Covalent Organic Frameworks by Probing Interfacial Water Structure using Vibrational Sum Frequency Generation Spectroscopy
Authors: Pandey Ravindra , Kumar Yogesh , Varanasi Srinivasa
Published: January 2025

Covalent organic frameworks (COFs) are an emerging class of porous materials with diverse applications across multiple fields. Most of the ongoing research related to COFs predominantly focuses on developing new materials through novel linkers and innovative reactions, as well as exploring their applications. A detailed molecular-level understanding of COF synthesis is essential for developing advanced materials. The water structure adjacent to COFs can significantly influence the design of highly efficient materials for heterogeneous catalysis, photocatalytic water splitting, and water purification, as well as aid in understanding the charge storage mechanism in COF-based electrodes at electrode/electrolyte interfaces. To address this issue, we synthesized a 2D COF thin film via photon-assisted imine condensation at the water-air interface and investigated the process using vibrational sum frequency generation (VSFG) spectroscopy. We examined the role of a catalyst, light, and interfacial water molecules in the synthesis of COF. VSFG spectroscopy is utilized to successfully distinguish between amorphous and crystalline thin films of COF on the water surface. Moreover, it was found that water exhibits increased ordering and stronger hydrogen bonding in proximity to COF interfaces.
Clinical efficacy of choledochoscopy using pancreaticobiliary imaging-guided catheter to diagnose and treat biliary pancreatitis via the cystic duct, common bile duct, and duodenum
Authors: Li Po , Cheng Jianrong , Hou Yiru , Cui Feifei , Chen Qian , Ma Ruirui , Sun Huiling , Wang Nan , Yao Jiaxi , Chen Xiaojun
Published: January 2025

This clinical study aimed to explore the clinical efficacy of performing a choledochoscopy with a 9FR disposable pancreaticobiliary imaging-guided catheter to diagnose and treat acute biliary pancreatitis caused by common bile duct stones. A retrospective analysis was conducted involving patients who underwent laparoscopy with a 9FR disposable pancreaticobiliary imaging-guided catheter. Endoscopy was conducted via the gallbladder duct, common bile duct, hepatopancreatic ampulla, duodenal papilla, and descending duodenal lumen between January 2020 and January 2024 at our institution. Clinical indicators were analyzed and postoperative treatment effects were monitored. Sixty-six patients underwent surgery, including fifty with secondary common bile duct stones and sixteen with primary common bile duct stones. The operative time ranged from 80 to 290 minutes ( 138.79 ± 36.86 minutes). Intraoperatively, blood loss ranged from 5 to 50 mL (13.03 ± 7.06 mL) and average postoperative lengths of hospital stays of 9.95 ± 2.43 days were recorded. All patients were followed up for 6 to 12 months. No pancreatitis, recurrence of common bile duct stones, bile fistulas, or stenosis of the common bile duct were observed. Abdominal ultrasound examination of the common bile duct and pancreas showed no abnormalities, and biochemical indicators were within normal ranges. Laparoscopy using a 9FR disposable pancreaticobiliary imaging-guided catheter through the gallbladder duct, common bile duct, hepatopancreatic ampulla, duodenal papilla, and descending duodenal cavity is beneficial for diagnosing and treating common bile duct microstones. The procedure can relieve biliary obstruction, curb further progression of acute biliary pancreatitis, accelerate the recovery process of postoperative gastrointestinal function, improve liver and pancreatic function in patients, and reduce the incidence of related complications. This technique is safe and feasible; however, the surgical difficulty is high. The operator must be skilled in laparoscopy and choledochoscopy, and minimally invasive surgical techniques. Cases must be strictly screened.
A Cloud-Edge Collaborative Model Training Framework for Assisted Classification of Middle Ear Diseases Based on Ultra-High-Resolution Temporal Bone CT ImagesAbstract
Authors: Wu Ting , Tang Yu , Che Zigang , Zhao Jiangjiang , Wang Jue , Wu Yanfeng , Meng Wei , He Shuangba
Published: January 2025

Objective: Cholesteatoma and otitis media are two of the most common middle ear diseases, of which the treatment principles are different, making the differentiation between them of significant importance. Both chronic suppurative otitis media (CSOM) and middle ear cholesteatoma (MEC) can appear on CT images as low-density soft tissue-like masses partially filling the middle ear and mastoid cavities. However, typical CT imaging of MEC may show progressive destruction of auditory structures and adjacent cranial bones. Compared to high-resolution CT (HRCT), ultra-high-resolution CT (U-HRCT) offers inherent continuity and a more detailed display of the fine structures of the middle ear. This study proposes a "cloud-edge" collaborative training framework for middle ear disease classification that exploits temporal bone U-HRCT imaging data. By integrating the YOLO recognition algorithm, this framework aims to achieve auxiliary classification of MEC and CSOM based on U-HRCT images.
Methods: In the cloud-edge collaborative framework, the edge devices acquire U-HRCT imaging data and perform auxiliary classification of middle ear diseases using image recognition and inference techniques. The imaging data collected by the edge devices are transmitted to the cloud, where a unified model training process is executed, and the model containers are then deployed to the edge devices for future auxiliary diagnosis. The framework employed Mixup and Mosaic methods for data augmentation to enhance model robustness and improve generalization performance. The object detection models of the You Only Look Once (YOLO) family was used, and the final model selection was made based on their performance.
Results: This study found that this cloud-edge collaborative framework can effectively classify temporal bone U-HRCT imaging data for MEC and CSOM. In the test set, the framework successfully collected real CT image data, performed data processing and conducted model training as designed. Eventually, multiple models were trained, with different levels of detection ability assessed by selected metrics, allowing for trade-offs in model selection considering computation time and accuracy. The selected model was then deployed to the edge, where they performed auxiliary classification tasks at the edge device.
Conclusions: This study discussed the significance of temporal bone U-HRCT imaging in the diagnosis of CSOM and MEC and proposed a cloud-edge collaborative model training framework for auxiliary classification from U-HRCT imaging data. This approach maximizes the utility of the data, fully leverages the diversity of image recognition algorithms, and ensures a high level of accuracy in classification.
Acetaminophen, a new tool to refine experimental infectious processes: the case of murine toxoplasmosis
Authors: Moiré Nathalie , Cauty Axel , Rossignol Christelle , Beaugé Corinne , Mérat Laetitia , Lortscher Emilie , Debierre-Grockiego Françoise , Dimier-Poisson Isabelle , Riou Mickaël
Published: January 2025

Over the past few years, animal welfare has taken more place in society and especially in scientific research. It has become necessary to refine the experimental procedures as much as possible in infectiology as in our reference model, toxoplasmosis, in agreement with the 3Rs rule and different ethical concerns. Thus, the establishment of a treatment using analgesics would relieve animals acutely infected with Toxoplasma gondii. However, the use of this analgesic should in no way alter the pathophysiology of the disease and the immune response of the host, so as not to interfere with the initial scientific study. Currently, little is known about the use of acetaminophen in an infectious model. In the present work, we studied the impact of acetaminophen at a reference dose of 30 mg/kg/day in a murine model of acute toxoplasmosis. To do this, zoonotic, telemetric, behavioral, histological and immune parameters were analyzed to better characterize the consequences of a treatment with acetaminophen either via gavage or via self-medication in Gel Water. Acetaminophen administered by gavage did not induce cellular or tissue toxicity and did not alter the physiological development of mice either. Moreover, the very nature of Gel Water, independently of APAP, has had an impact on the immune response. The acetaminophen improved the general well-being and slowed down the appearance of clinical signs without modifying the physiopathology or the immune responses induced by T. gondii. These first results in mice validated our initial hypothesis that acetaminophen appears to be a pharmacological tool to refine and improve animal welfare during the acute phase of toxoplasmosis. Therefore, our project has highlighted the combination of specific markers to contribute to animal welfare in mice. In the long term, the use of acetaminophen could be extended to other infectious models with other target animal species.
Earthquake Rupture Velocity and Stress-Drop Interaction in the Campi Flegrei Volcanic Caldera
Authors: Zollo Aldo , Nazeri Sahar , Muzellec Titouan , Toro Giulio Di
Published: January 2025

During earthquake ruptures, dynamic and static stress releases play a key role in controlling how much energy is radiated as seismic waves, how large is the fault slip, and how quickly the rupture spreads out of the nucleation zone. Here we exploit a time-domain technique using P- and S-waves log-displacement records to estimate the seismic moment, rupture velocity, and radius of the ruptures of 32 Md 3+ earthquakes detected during the 2020-2024 seismic crisis at Campi Flegrei caldera, Italy. Seismic ruptures propagated at sub-shear velocities (0.4-0.9 of shear wave speed) along 100-1000m in radius fault surfaces. Stress-drop estimates show a statistically significant inverse relation with the rupture velocity. The low seismic radiation efficiency confirms that the radiated energy is only a small fraction of the total available strain energy at the source which is mostly dissipated by friction and fracture-related processes. We argue that in volcanic calderas, the energy dissipation related to off-fault rock damage processes is the main cause for low radiation efficiency and inverse relation between the rupture velocity and stress drop. In this geologic environment, ruptures with higher stress drop favor extensive off-fault damage, which can prevent rupture propagation for long distances, limiting the maximum attainable earthquake magnitude.
The Comparative Effectiveness of Single versus Double Perclose ProGlide Devices in Achieving Transfemoral AortIc Valve Replacement Access Site Closure: A Prospective, Multicenter, Randomized Controlled Trial (Single-Closure)
Authors: Jiang Jubo , Wang Lihan , Hu Po , Ren Kaida , Lin Xinping , Zhu QiFeng , Fan Jiaqi , He Yuxin , Guo Yuchao , Liu Qiong , Liang Jie , Li Huajun , Yan Huixiang , Liu Xianbao , Wang Jian’an
Published: January 2025

Background
The Double Perclose ProGlide™ (Abbott Vascular Devices) is widely adopted device for closing the main arterial access in transfemoral transcatheter aortic valve replacement (TF-TAVR),. Prior studies have compared the single device versus double device approach, but yielding controversial results, highlighting a gap in clinical randomized controlled trials.
Trial design
This is an investigator-initiated, open-label, multicenter, randomized controlled trial designed to compare the clinical outcomes of single versus double Perclose closure devices. Eligible participants will include patients over 65 years ,with severe aortic stenosis and are indicated for TF-TAVR. These patients will be randomly assigned in a 1:1 ratio to either the single Perclose closure group or the double Perclose closure group. The primary end point of the trial is the rate of access site or access-related major and minor vascular complications,as defined by the VARC-3 criteria.
Conclusion
This trial aims to compare the clinical outcomes of single versus double Perclose closure. We aim to provide valuable insights into the optimal strategy for large-bore vascular closure in TAVR patients.
Is Endocan a Reliable Biomarker of Bone Tumours
Authors: ŞENOCAK EYÜP , ÖZTÜRK NURİNNİSA , AYGÜN ÜMİT , TOY SERDAR , ÇİÇEK ALİ CAN , AKSAY MEHMET FATİH , HALAÇ ORKUN
Published: January 2025

Endocan, which has an important role in inflammation and angiogenesis, is known to be an effective mediator in evaluating tumour progression and prognosis in many malignant tumour groups. Here, we investigated whether endocan is a biomarker that can be used to distinguish malignant from benign bone tumours. In all, 30 patients with pathologically malignant bone tumours, 30 patients with benign bone tumours, and 30 control patients without a tumour history were included in the study. The age and sex distributions of the three groups were statistically similar. Before biopsy, blood samples were taken from these patients without any medical or surgical intervention. The samples were centrifuged and stored under appropriate conditions. Inflammatory mediators other than endocan were also studied. There was a significant difference in endocan levels in the malignant bone tumour group compared to the benign bone tumour group. Similarly, a significant difference was detected in the group without bone tumours and the groups with benign or malignant bone tumours. A statistically significant correlation was observed between levels of serum endocan and the malignancy potential of bone tumours. The results indicate that endocan can be used as a biomarker to determine whether a bone tumour is benign or malign. Also, according to endocan levels, the severity of a bone tumour can be determined.
Collision Avoidance for Autonomous Ships Using Laser Rangefinder Technology
Authors: Nurdiansari Henna , Septianto Aditya , Setiawan Ariyono
Published: January 2025

This research aims to evaluate the performance of the Collision Avoidance System (CAS) Using a laser rangefinder sensor for Maritime Autonomous Surface Ships (MASS)[1], The system is designed to prevent collisions by providing early warnings and instructions based on the proximity of other objects. The study focuses on testing the CAS’s ability to detect obstacles and trigger Traffic Advisory (TA) and Resolution Advisory (RA) responses[2],[3]. Derived from the Airborne Collision Avoidance System (ACAS) used in aircraft, the maritime CAS system issues warnings and avoidance instructions when potential collisions are detected. It uses a laser rangefinder sensor to measure the distance to obstacles, triggering the TA or RA modes accordingly[4]. The system was tested through experiments assessing the sensor's detection range, obstacle sensitivity, battery life, and performance under varying light conditions. During the tests, the CAS responded appropriately by activating the TA with a buzzer and LED when obstacles were detected within 4000 mm, and engaged the RA by slowing the motor and adjusting the rudder when obstacles were within 2000 mm[5]. The system exhibited high sensitivity and reliable performance in different environments. This research contributes to the development of autonomous maritime technologies and highlights the potential of laser rangefinder sensors to enhance vessel safety and prevent accidents in busy marine settings
Benchmarking commercial depth sensors for intraoperative markerless registration in neurosurgery applications
Authors: Villa Manuel , Sancho Jaime , Rosa-Olmeda Gonzalo , Chavarrias Miguel , Juarez Eduardo , Sanz Cesar
Published: January 2025

Purpose: This study proposes a generalization of markerless patient registration in image-guided neurosurgery based on depth information. The work builds on previous research to evaluate the performance of a range of commercial depth cameras and two different registration algorithms in this context.
Methods: A multimodal experimental setup was used, testing five depth cameras in seven configurations. Fiducial Registration Error (FRE) and Target Registration Error (TRE) metrics were calculated using Iterative Closest Point (ICP) and Deep Global Registration (DGR) algorithms. A phantom head model was used to simulate clinical conditions, with cameras positioned to capture the face and craniotomy regions.
Results: The best-performing cameras, such as the D405 and Zed-M+, achieved TRE values as low as 2.36 ± 0.46 mm and 2.49 ± 0.35 mm, respectively, compared to manual registration that obtains a 1.37 mm error. Cameras equipped with texture projectors or enhanced depth refinement demonstrated improved performance. The proposed methodology effectively characterized the suitability of the camera for the registration tasks.
Conclusions: This study validates an adaptable and reproducible framework to evaluate depth cameras in neurosurgical scenarios, highlighting D405 and Zed-M+ as reliable options. Future work will focus on improving depth quality through hardware and algorithmic improvements. The experimental data and the accompanying code were made publicly available to ensure reproducibility.
Gumbel function parameters estimation for annual maximum precipitation data using the Whale Optimization Algorithm (WOA)
Authors: ARGANIS-JUÁREZ MARITZA L , Preciado-Jiménez Margarita E. , Mendoza-Reséndiz Alejandro , Roblero-Hidalgo Rodrigo
Published: January 2025

Hydrological variables frequency analysis is crucial for designing and operating hydraulic infrastructure. The Gumbel distribution is commonly used to model extreme events like floods. This study investigates the Whale Optimization Algorithm (WOA) use, a metaheuristic inspired by humpback whale hunting, to estimate the parameters of the Gumbel distribution for annual maximum precipitation data from a climatological station located at Hidalgo State, Mexico. The WOA was compared with moments method. Performance was evaluated using adjustment (EEA) standard error and root mean square error (RMSE). Results demonstrated comparable performance between these two methods. The WOA offers several advantages, including flexibility and adaptability to complex optimization problems. This study highlights the potential of the WOA as a valuable tool for parameter estimation in hydrological frequency analysis, improving the accuracy and reliability of designs for hydraulic structures under conditions of uncertainty and climate change.
Relationship between Anogenital Distance and Testicular Position in Male Infants with Cryptorchidism with and without Hypospadias
Authors: Nagla Salah , Elrifaey Shaymaa , abdelnabi hend , hagras ayman , arafa ahmed , hamza mohamed , dawood waleed
Published: January 2025

Purpose
Anogenital distance (AGD) may indicate hypoverilization and subsequently serve as a predictor future reproduction. In both undescended testis with and without hypospadias, our goal was to study the relationship between testicular position and AGD.
Methods
From March 2021 to January 2023, the study was conducted on male infants with and without hypospadias and age-matched controls. Based on the infants' ages, we divided them into four. Group I: under six months, Group II: 7–12 months, Group III: between a year and eighteen months, and Group IV: 19 months up to two years of age. From the verge of the anus to the penile base, the AGD was measured. Clinical examination resulted in the classification of testicular location as high scrotal, inguinal, and non-palpable.
Results
Patients with cryptorchidism had AGD means that were substantially lower than those of controls in Groups I, II, III, and IV, respectively (31 ± 2, 33 ± 3), (35.9 ± 4, 37.9 ± 5), (39.9 ± 1.2, 41 ± 1.5), and (40 ± 1.9, 44 ± 1.7). The group of patients with cryptorchidism and hypospadias differed significantly from the controls and those without hypospadias. AGD in patients with upper scrotal locations was substantially shorter. Penile length and AGD of the examined groups exhibited a positive and significant connection.
Conclusions
Shorter AGD is linked to a higher prevalence of hypospadias and cryptorchidism in male babies in comparison to normal children. The position of the undescended testis is higher in relation to a shorter AGD.
Investigating the Association Between Maternal Folic Acid Supplementation and the Occurence of Ankyloglossia in Newborns
Authors: Kesuma Yudianita , Soedjadhi Rismarini , Bernolian Nuswil , Lestari Peby Maulina , Liana Phey , Indrayady Indrayady , Ramadanti Afifa
Published: January 2025

Background
In both popular and scientific literature, an association between tongue tie (ankyloglossia) and folic acid intake during pregnancy is often suggested, although this has not been systematically investigated. Some literature considers this association to be anecdotal. This study aimed to clarify the role of folic acid during pregnancy in the development of tongue tie babies.
Methods
A cross-sectional study was conducted from August to September 2021. Participants were pregnant women who delivered at Moh. Hoesin hospital and Hermina hospital in Palembang. Subjects were recruited using consecutive sampling. Tongue tie in babies was determined using the Hazelbaker’s Assessment Tool for Lingual Frenulum Function (HATLFF). Folic acid levels maternal serum were measured using ELISA DRG® testing.
Results
Among 144 mothers included in the study, 26.6% of their babies were diagnosed with tongue tie. There was a statistically significant associaton between maternal serum folic acid levels and the occurrence of tongue tie (p = 0.033, OR = 2.130 95% CI = 1.002–4.525). The risk factors for elevated maternal folic acid serum included the consumption of pasta, melon, and lettuce during pregnancy (p = 0.015, OR = 4.05; p = 0.014, OR = 3.91; p = 0.015, OR = 0.31), respectively.
Conclusion
The prevalence of tongue tie was high and showed a significant association with elevated level of maternal serum folic acid.
Exponential-trigonometric Optimization Algorithm with Multi-Strategy Fusion for UAV three-dimensional path planning
Authors: Xu Tao , Chen Chaoyue , Meng Fanfan , Ma Dongdong
Published: January 2025

With the rapid advancement of Unmanned Aerial Vehicle (UAV) technology, trajectory planning has become a focus research. This paper proposes a three-dimensional path planning method for UAV based on an improved Exponential-triangle Optimization Algorithm (IETO). By constructing a multi-objective optimization function that considers factors such as path length, flight altitude, and turning angle, a comprehensive evaluation of path quality is able to be achieved. The IETO algorithm incorporates interval-constrained logistic chaotic mapping, dynamic reverse learning strategy, and an adaptive artificial bee colony algorithm (ABC) escape mechanism within the ETO algorithm. These enhancements prevent premature convergence to local optima. Through benchmark function tests on the CEC2017 test set and simulations in peak threat environments, the IETO algorithm demonstrated superior robustness. Compared to mainstream algorithms like GWO and GJO, IETO achieves the best performance in 62% of function tests. It also demonstrates exceptional performance in solving complex functions, effectively balances exploration and exploitation capabilities. In mountainous environments, the IETO algorithm generates the smoothest paths with the lowest costs and quickly converges to the optimal solution.