bluuebunny/crossref_metadata_2025 huggingface dataset:
Parenteral nutrition, sepsis, acute heart failure and hepatotoxic drugs are related to liver test disturbances in critically ill patients
Authors: Rosseel Zenzi , Cortoos Pieter-Jan , Jonckheer Joop , Cools Wilfried , Vinken Mathieu , Reynaert Hendrik , De Waele Elisabeth
Published: March 2023

Background and aims: In a clinical intensive care setting, parenteral nutrition (PN) is often associated with liver dysfunction although other contributing factors such as sepsis, acute heart failure (AHF) and hepatotoxic drugs can be present. This retrospective study aimed to identify the impact of these factors on liver test dysfunction with focus on PN.
Methods: Adult ICU patients admitted for ≥3 days and treated with PN for ≥ 3days were included. Liver test disturbances were recorded at day 1 of PN based on elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT) or alkalic phosphatase (AP). The presence of AHF, sepsis and 5 previously selected hepatotoxic drugs was recorded. Volume of PN, calorie abundance, amount of proteins, lipids and carbohydrates were monitored. A linear mixed-effect model was used to assess the contribution of PN, sepsis, AHF and drugs to liver test abnormalities. Nutritional adequacy was defined as the caloric, protein, lipid and carbohydrate intake compared to theoretical needs.
Results: Liver test abnormalities, presence of sepsis and AHF were the main confounders in predicting liver parameters in 224 ICU patients treated with at least 3 days PN. Presence of sepsis caused an average increase of 43% ± 7% for total bilirubin (TB), 36% ± 14% for gamma-glutamyltransferase (GGT) and 32% ± 8% for AP. Secondly, presence of AHF caused an increase of 29 ± 13% % for ALT and 75% ± 14% for AST. Volume of PN administrated caused an increase of 10% ± 5% for ALT and 14% ± 1% for AST. Carbohydrate intake exceeded nutritional recommendations and protein and lipid intake was not sufficient.
Conclusion: Liver test disturbances in critically ill patients on PN for at least 3 days have multifactorial associations with sepsis and AHF being the main confounders. Volume of PN and hepatotoxic drugs had a smaller impact. Feeding adequacy revealed opportunity for improvement by reducing carbohydrate and increasing lipid and protein content.
Effectiveness of Geometric Quality Control Using a Distance Evaluation Applied to an Ifsar Dem
Authors: ZELASCO José Francisco , ENNIS Kevin , SULPIS Bárbara , AUSINAGA José Luis FERNÁNDEZ
Published: March 2023

A new method, the Perpendicular Distance Estimation Method (PDEM), to estimate the precision of a Digital Elevation Model (DEM) with its effectiveness in the evaluation of vertical and horizontal error is presented in a previous work: when the error is accepted as random the PDEM may evaluate the vertical error, - without systematic error as it happens using the vertical distance method- and also may evaluate the horizontal one (horizontal isotropic error) under certain irregular terrain conditions, without using benchmarks.
In the case of the DEM obtained by IFSAR techniques, the error in the vertical axis is correlated with the error in the range-axis. A rotation has to be done to find not correlated directions.
The contribution of this paper is to assess the PDEM effectiveness to estimate the error in the three not correlated directions: the beam axis, the azimuth axis and the axis normal to the previous two (y’; the rotated range axis). Simulations are presented in detail, starting from a real reference DEM, with 100 000 points. The results confirm that the PDEM error estimation is good in the beam and in the y’ directions, and the more uneven the terrain, the better the estimate of the azimuth axis error.
First report on kdr mutations in wild populations of Aedes aegypti from Argentina determined by a novel multiplex high resolution melting PCR method
Authors: Illanes Alberto N. Barrera , Micieli María Victoria , Shimabukuro Marina Ibáñez , Santini Ma. Soledad , Martins Ademir J. , Ons Sheila
Published: March 2023

Background:
Aedes aegypti is an urban mosquito vector of dengue and other arboviruses. During epidemic periods, pyrethroid insecticides are used for the control of adult mosquitoes; the worldwide distributed resistance to these insecticides is a cause of failures in vector control campaigns. The primary target of pyrethroids is the voltage-gated sodium channel; point mutations on this channel, called kdr mutations, are associated with pyrethroid resistance. Two kdr mutations, called V1016I and F1534C, augmented in frequency in natural populations of Ae. aegypti from the Americas in the last decade; their association with pyrethroid resistance has been largely demonstrated in field populations throughout the country, and in in vitro assays. The diagnostic of kdr polymorphisms allows an early detection of insecticide resistance spreading, which is critical for timely decisions on vector management. Given the relevance of resistance management, high-throughput methods for kdr genotyping are valuable tools for resistance monitoring programs. These methods should also be cost-effective, to allow regional-scale surveys. Despite the extended presence of Ae. aegypti and the incidence of dengue in Argentina, the presence, abundance and distribution of kdr mutations were not reported in this country up to date.
Methods:
Aedes aegypti samples were collected from Metropolitan Area of Buenos Aires, and northern localities of Tartagal (Salta province) and Calilegua (Jujuy province). A high resolution melting assay was developed for the simultaneous detection of V1016I and F1534C kdr mutations.
Results:
We demonstrate the presence of kdrmutations in Argentina in regions under different selection pressure with pyrethroids. We also report a multiplex high-throughput assay based in high resolution melting PCR for the simultaneous genotyping of V1016I and F1534C kdr mutations.
Conclusions:
We report for the first time the presence of kdr mutations in distant populations from Argentina, with different epidemiological situations and different history of mosquito control efforts. We have developed a high-throughput method for the genotyping of kdr mutations in Ae. aegypti from the American continent. Given its convenient cost and running time, this method can be incorporated in control campaigns for monitoring the presence and spreading of kdr alleles.
Footprints of stress in vitiligo: Association of the 5-HTR2C rs6318 variant
Authors: Yilmaz Izel , Yazici Serkan , Ergoren Mahmut Cerkez , Baskan Emel Bulbul , Oral Haluk Barbaros , Aydogan Kenan , Temel Sehime Gulsun
Published: March 2023

Vitiligo is a chronic autoimmune progressive dermatological disease and stress known to have impact on the development of vitiligo. However, the effect of serotonin has not been clearly explained for disease progression. Therefore, this study aimed to clarify stress induced 5-HTR2C rs6318 variant and its association with vitiligo pathogenesis.
Study conducted with 108 vitiligo patients and 107 age-sex matched, unrelated healthy subjects as control group. Real Time-PCR analysis method was used for genotyping the 5-HTR2C variation. Genotype and allele frequencies considered for both control and patient groups. Genotype distributions for the Hardy-Weinberg Equilibrium (HWE) were analyzed. Vitiligo-related risk measures of different genotype combinations examined. Genotype correlations of the variant also analyzed based on gender difference, age onset of vitiligo, Koebner phenomenon history, clinical subgroups, treatment types, presence of other autoimmune diseases, vitiligo presence in family members and other autoimmune diseases in relatives.
No statistically significant difference in 5HT-R2C receptor genotypes and allele frequencies between patient and control has been found. Genotype frequencies were not in agreement with the Hardy-Weinberg Equilibrium in the patients’ group (p < 0.00001). Frequency of the risk allele (allele C) was not significantly different between the patient and control groups (p = 0.1392). However, in the clinical subgroup analysis, the risk allele presence detected significantly higher for early age onset (< 40 years) vitiligo development (p = 0.0365) and lower in Koebner phenomenon history (p = 0.0276).
As a result, although there was no association between the 5-HTR2C variant rs6318 and vitiligo, the current results indicated that there is a strong association between the 5HTR2C rs6318 variant C allele and early age onset vitiligo development.
Perspectiva dialógica de Gadamer: aporte a una comprensión de la ampliación del contenido de la memoria
Authors: Cuchumbé Holguín Nelson Jair
Published: March 2023

El objetivo de este artículo es destacar cómo desde la perspectiva dialógica de Gadamer, se puede contribuir a una comprensión de la ampliación del contenido de la memoria que se les plantea a los actores sociales en su presente, caracterizados por no atender ni escuchar la experiencia del otro. El enfoque metodológico acogido es comprensivo-interpretativo, centrado en el análisis de algunos elementos que subyacen al modo como Gadamer entendía el concepto de formación, y de la manera como dicho pensador concebía la relación entre comprensión y actualización. Al respecto, se destacan dos resultados: (1) la exigencia histórica y existencial que presupone la formación y actualización de la memoria halla su justificación en el vínculo entre las distintas manifestaciones de mundo construidas por otros en el pasado y el esfuerzo permanente por conformar memoria acorde con el presente; y (2) hablar de memoria es hablar de igual responsabilidad en el cometido de confirmar y renovar el pasado en el presente, relación de coimplicación que determina la forma de participación de un ser humano o grupo social en la actualización de la memoria. Para concluir, cualquier esfuerzo de ampliación del sentido de la memoria involucra una experiencia de asociación diferente con lo recordado del pasado, lo cual se hace posible si esa relación suscita el aporte libre desde las expectativas que determinan a los receptores capaces de renovar el contenido de la memoria en otro tipo de sentido productivo.
Talât Paşa Suikastının Amerikan Basınındaki Yansımaları
Authors: IŞIN Semra
Published: March 2023

Mehmed Talât Paşa, Osmanlı Devleti’nin yıkılmasının hemen öncesinde döneme damgasını vuran isimlerdendir. I. Dünya Savaşı sonrasında henüz siyasi hayatta aktif bulunduğu süreçteki faaliyetlerinden bilhassa Ermenilerin Sevk ve İskân Kanunu kapsamındaki göçünden ve bu sıra yaşanan sözde ölümlerden sorumlu tutulan paşa, 1918’da Almanya’ya gitmek zorunda kalmıştır. İttihat ve Terakki Cemiyeti kadrosu dahilinde yer almaya başladıktan sonra, devleti içinde bulunduğu durumdan kurtarmanın yolunu arayan Talât Paşa, bu bağlamda gerek hapis yatmış gerekse sürgün niteliğindeki ayrılılar yaşamış, ancak bu amacından hiç vazgeçmemiştir. Nitekim Osmanlı politik hayatında üstlendiği roller sonucunda yaklaşık iki yıl sonra kaçtığı Almanya’da bir seri halini alacak olan Ermeni suikastlarının bir faili olarak 1921 yılında öldürülmüştür. Ancak yabancı basına da yansıyan Talât Paşa’nın öldürülmesi batılı devletler tarafından daha ziyade suikastçının mağduriyeti vasıtasıyla Ermeni meselesi haline dönüştürülmüş, Talât Paşa suikastı üzerinden yaşandığı iddia edilen Ermeni katliamının propagandası yapılmıştır. Paşa’nın katlinden sorumlu tutulan Amerikan basınında da geniş ölçüde yer bulan Talât Paşa’nın katli ve davası haberlerine de bakıldığında işlenen cinayet “adaletin tecellisi” olarak kamuoyuna aktarılmış; paşa maktul değil de asıl suçluymuş gibi tanıtılmıştır.
Cumhuriyet Halk Partisi İktidarı Döneminde Büyük Doğu’nun Türk İnkılabına Bakışı (1943-1950)
Authors: GÖK Hacı Veli
Published: March 2023

26 Mayıs 1904 tarihinde İstanbul’da dünyaya gelen Necip Fazıl Kısakürek düşünsel, ideolojik, edebi ve politik arenada Türk toplumu üzerinde önemli bir etkiye sahip olmuştur. Kısakürek yaşamının bir bölümünü özellikle 1943 yılında Büyük Doğu Dergisi’ni çıkarana dek katı bir İslami ideolojiden uzak geçirirken özellikle Abdülhakim Arvasi ile tanışması ve ardından gelen süreçte Büyük Doğu Dergisi’ni çıkarması ile birlikte CHP ve Türk inkılabına karşı eleştirel bir tavır takınmıştır. Çalışmanın konusunu teşkil eden Büyük Doğu Dergisi’nin Türk inkılabına karşı bakışı çerçevesinde Kısakürek’in Büyük Doğu Dergisi aracılığı ile Türk inkılabına karşı sert bir tavır takındığı görülmektedir. Kısakürek’in ve Büyük Doğu Dergisi’nin Türk inkılabına karşı takınmış olduğu bu sert tavrın muhtevasını ise yapılan inkılapların madde planında kaldığı ve manevi anlamda Türk milletine hitap etmediği yönünde düşünceler oluşturmaktadır. Öyle ki, Büyük Doğu Dergisi, madde planında kurtarılmış olan vatanın manevi planda İslam ile uyuşmadığını, inkılapların Türk milletinin talep ve ısrarı üzerine değil jakoben bir yöntemle uygulamaya sunulduğunu bundan dolayı da Türk milleti nezdinde kabul görmediğini iddia etmiştir.

Öte yandan inkılapların Batı temelli bir yaklaşımla tatbik edilmesinin eleştirildiği Büyük Doğu Dergisi’nde bu gibi yaklaşımların “kopyacılıktan” ibaret olduğu ve Türk milletinin ruh planına kesinlikle uygun olmadığı da sıklıkla dile getirilmiştir. Büyük Doğu Dergisi’nin inkılaplar karşısındaki bu sert tutumu muhtelif tarihlerde derginin kapatılması ile sonuçlanmış ancak dergi kapatma kararlarından bir süre sonra tekrardan açılmıştır. Burada dikkat çekilmesi gereken nokta derginin tekrardan açıldığı tarihlerde kapatma gerekçelerine neden olan değerlendirmeleri yinelemesi ve CHP’nin iktidar olduğu dönemde CHP’yi ve inkılapları sert bir şekilde eleştirmesidir. Şüphesiz ki, Büyük Doğu Dergisi’nin CHP ve inkılaplara karşı takınmış olduğu sert tavır devlet mekanizmasını harekete geçirmiş, derginin CHP iktidarı ile iyi ilişkiler kuramamasına neden olmuş, Necip Fazıl Kısakürek ve derginin Devletin yakın takibine alınmasına yol açmıştır. Bu bağlamda çalışma, Cumhuriyetin ve inkılapların halka benimsetilmeye çalışıldığı CHP iktidarı döneminde Büyük Doğu Dergisi ile devlet mekanizması arasındaki çekişmenin ayrıntılı bir şekilde ortaya konulması açısından önem arz etmektedir
Controlled Release of Rutin from Babassu Coconut Mesocarp Starch Films
Authors: Carvalho Liane , Bezerra Cicero , da Rocha Claudia , de Oliveira Letícia , Vasconcelos Luna , Santana Sirlane
Published: March 2023

Rutin is found in several plant sources and has therapeutic effects with excellent healing potential. Its use is restricted due to its low aqueous solubility, requiring a carrier matrix that allows an adequate delivery system. Biopolymer matrices can release the active ingredient in a controlled manner, keeping it within the therapeutic range and minimizing side effects. This study used babassu mesocarp starch films prepared by different routes as Arrabidaea brachypoda DC Bureau (AB) leaf extract carrier matrices to produce a controlled release system. The films were produced by the casting method, and the AB extract was incorporated in the proportion of 0.5% m/m of dry starch. The presence of the extract in the matrix was identified with Fourier transform infrared spectroscopy (FTIR) and X-ray diffractometry (XRD) data and functional analyses. The in vitro release of the AB extract was carried out in phosphate-buffered saline, pH 7.4, and adapted to the Korsmeyer-Peppas model, with coefficients of determination (R2 ) ≥ 0.9018. The release exponents (n) revealed that the release mechanism is diffusion controlled. Different kinetic constant values (k) indicated that the treatments employed allowed slower and more controlled release profiles, according to the route chosen for matrix preparation. Thus, the materials produced emerge as a new approach to releasing vegetable extracts.
Genlik Değişiminin Titreşimli Gerilim Giderme Verim Oranı Üzerindeki Etkisi
Authors: GÖNENLİ Can , DAŞ Oğuzhan
Published: March 2023

Bu çalışmada, literatürde “Vibratory Stress Relief” adıyla bilinen “Titreşimli Gerilim Giderme” yöntemi, ANSYS programı aracılığıyla sonlu elemanlar yöntemi kullanılarak simüle edilmiştir. Paslanmaz çelik ve alüminyum malzeme kullanılarak modellenen üç farklı geometrideki öngerilmeli plakalar, üçer farklı öngerilme durumu için incelenmiştir. Öngerilmeli plaka oluşturabilmek için öncelikle plakaya yer değiştirme uygulanmış ve sonrasında serbest bırakılmıştır. Uygulanan yer değiştirme miktarı ile farklı değerlerde üçer öngerilme durumu yaratılmıştır. Öngerilmeli plakanın birinci rezonans frekansı tespit edilmiş ve devamında farklı genlik miktarlarında gerilim giderme işlemi gerçekleştirilmiştir. Kare ve iki farklı dikdörtgen geometriye sahip plakalarda gerçekleştirilen ANSYS simulasyonlarına göre, paslanmaz çelik için %80 ile %95 arasında artık gerilme değerlerinin azaldığı görülürken alüminyum için ise bu aralığın %71 ile %91 bandında olduğu görülmüştür. Ayrıca her bir plaka için oluşturulan gerinim-gerilme grafiklerine göre, yapı içerisindeki öngerilme miktarının, farklı genlik değerlerindeki titreşimler ile farklı oranlarda azaldığı tespit edilmiştir. Öngerilme miktarının artmasıyla plakalara uygulanabilecek titreşimli gerilim giderme genliği aralığının da arttığı görülmektedir.
Kanaldaki Jet Akış Sayısına Bağlı Olarak Farklı Model Yüzeylerinden Olan Isı Transferi ve Akış Yapısının Analizi
Authors: KARABULUT Koray , ALNAK Yeliz
Published: March 2023

Çalışmada, Dh jet giriş genişlikli kanallardaki düz ve üçgen basamak modelli yüzeylerden olan ısı transferi üç adet hava jeti akışı kullanılarak araştırılmıştır. Araştırmalar, sayısal olarak sürekli ve üç boyutlu k-ε türbülans modeli kullanılarak Ansys-Fluent bilgisayar programıyla gerçekleştirilmiştir. Kanal yüzeyleri adyabatik olup yalnızca model yüzeylerinde sabit ısı akısı bulunmaktadır. Çalışmanın sonuçları literatürde bulunan çalışmanın sayısal ve deneysel çıktılarıyla karşılaştırılmış ve uyumlu oldukları belirlenmiştir. Sonuçlar, her bir model yüzeyi için ortalama Nu sayısı ve yüzey sıcaklığının değişimi olarak verilmiştir. Farklı Re sayıları ve H/Dh oranlarında model yüzeyleri için kanal boyunca jet akışın hız-akım ve sıcaklık konturu dağılımları değerlendirilmiştir. Re=10000 için H/Dh=3’de düz basamak desenli model yüzeyinin Nuo sayısının, üçgen basamaklı yüzeyden %45,18 daha yüksek olduğu belirlenmiştir.
Esnek Üretim Sistemlerinin Dinamik Çizelgelenmesi için Çoklu Etmen Yaklaşımı ve Yönlendirme Kurallarının Karşılaştırılması
Authors: ŞAHİN Cenk , EROL Rızvan
Published: March 2023

Üretim ortamlarında, makineler ve otomatik yönlendirmeli araçlar gibi sistem öğelerinin kontrol edilmesi zor olabilmektedir. Etmen tabanlı sistemler, üretim ortamlarında iş kesintileri, makine arızaları gibi dinamik olaylar meydana geldiğinde operasyonları yönetmek için etkili yöntemler sunmaktadır. Bu çalışmada, Çoklu Etmen Sistemi (MAS) mimarisi aracılığıyla esnek bir üretim sistemindeki AGV’lerin ve makinelerin dinamik çizelgeleme problemine uygulanmış ve elde edilen sonuçları literatürde yaygın olarak kullanılan yönlendirme kurallarıyla karşılaştırılmıştır. Çoklu etmen tabanlı yaklaşımlar dağıtılmış, stokastik, sürekli ve yüksek hesaplama karmaşıklığına sahiptir. Etmenler arasında yapılan müzakereler ve teklif verme sonucunda uygun çizelgeler ortaya çıkar. Literatürden alınan bir vaka çalışması etmen mimarisine uygulanmış ve çevrimiçi çizelgeleme kuralları (yönlendirme/sevk kuralları) ile karşılaştırılmıştır. Elde edilen sonuçlara göre, MAS gerçek zamanlı olarak iyi çizelgeler üretebildiği ve makespan performans metriği açısından yaygın olarak kullanılan yönlendirme kuralları ile karşılaştırılabilir olduğu bulunmuştur.
Aortic valve replacement using a polytetrafluoroethylene leaflet valve in patients with a history of the Bentall–De Bono procedure: a case series
Authors: Bazylev V.V. , Voevodin A.B. , Potopalskiy I.D. , Karnakhin V.A. , Patel M.P. , Kuznetsova A.A.
Published: March 2023

Objective: To analyze outcomes of 4 transcatheter aortic valve replacements using a polytetrafluoroethylene leaflet valve in patients with a history of the Bentall–De Bono procedure.Methods: We retrospectively analyzed a series of 4 cases. From February 2019 to March 2022 in Federal Center for Cardiovascular Surgery (Penza, Russia), patients with a history of the Bentall–De Bono procedure underwent transaortic aortic valve implantation of the MedLAB-CT balloon-expandable valve under cardiopulmonary bypass and cardioplegia. Valve No. 25 was implanted in 3 patients, and 1 patient received valve No. 23.Results: According to echocardiography, valve hemodynamic performance improved in the postoperative period: mean and peak pressure gradients were 11.5 and 24 mm Hg, respectively; the median value of effective orifice area was 1.9 cm2, while mitral regurgitation in all cases did not exceed grade 1. Median cardiopulmonary bypass and myocardial ischemia times were 59 and 31 minutes, respectively. There was no immediate and remote mortality. No complications were reported in the postoperative period.Conclusion: The proposed replacement of the valved conduit’s compromised part after the Bentall–De Bono procedure can significantly reduce the extent of surgery, cardiopulmonary bypass and myocardial ischemia times, as well as simplify the procedure.
Received 1 December 2022. Revised 10 February 2023. Accepted 16 February 2023.
Informed consent: The patient’s informed consent to use the records for medical purposes is obtained.
Funding: The study did not have sponsorship.
Conflict of interests: The authors declare no conflict of interest.
Contribution of the authorsLiterature review: V.A. Karnakhin, I.D. PotopalskiyDrafting the article: V.V. Bazylev, A.B. Voevodin, I.D. Potopalskiy, V.A. KarnakhinCritical revision of the article: A.A. Kuznetsova, M.P. PatelSurgical treatment: V.V. Bazylev, A.B. VoevodinFinal approval of the version to be published: V.V. Bazylev, A.B. Voevodin, I.D. Potopalskiy, V.A. Karnakhin, M.P. Patel, A.A. Kuznetsova
Coronary artery and congenital heart diseases in adult patients: a case series
Authors: Podzolkov V.P. , Minaev A.V. , Chiaureli M.R. , Cheban V.N. , Golubev E.P. , Petrosyan K.V. , Sobolev A.V. , Zemlyanskaya I.V.
Published: March 2023

Background: The relevance of coronary artery disease treatment in congenital heart disease is related to the increasing number of older patients with congenital conditions, predisposing factors and continuous silent ischemia.Objective: To analyze clinical data and results of surgery in patients with a combination of congenital heart disease and hemodynamically significant coronary artery lesions.Methods: 17 patients (7 women (41.2%), 10 men (58.8%)) were included in the study. All of them underwent myocardial revascularization and congenital heart disease corrective surgery from 2003 to 2020. The mean age at the time of surgery was 57.2 years. The congenital diagnosis was an atrial septal defect (14 patients), partial anomalous pulmonary vein connection (1 patient), recanalization of atrial septal defect (1 patient), recanalization of ventricular septal defect (1 patient). In 7 cases congenital and coronary pathology correction were performed percutaneously — coronary stenting as the first stage, defect closure at an interval of 4 to 10 days as the second. One patient underwent stenting 7 months prior to an open-heart surgery. In 9 cases one-staged open-heart surgery was performed simultaneously. Results: At the hospital 1 patient died after surgery due to multiple organ dysfunction syndrome. In all other cases there were no symptoms of ischemia on discharge, the patients were in NYHA class I–II (New York Heart Association).Conclusion: The tactics of coronary revascularization is determined by the necessity of percutaneous or open-heart intervention. Myocardial revascularization may be preferable as the first stage, or a one-stage correction may be performed and proved by good results.
Received 14 October 2022. Revised 25 November 2022. Accepted 27 November 2022.
Informed consent: The patient’s informed consent to use the records for medical purposes is obtained.
Funding: The study did not have sponsorship.
Conflict of interest: The authors declare no conflict of interest.
Contribution of the authorsLiterature review: A.V. MinaevDrafting the article: A.V. Minaev, A.V. Sobolev, I.V. ZemlyanskayaCritical revision of the article: V.P. PodzolkovSurgical treatment: M.R. Chiaureli, V.N. Cheban, E.P. Golubev, K.V. PetrosyanFinal approval of the version to be published: V.P. Podzolkov, A.V. Minaev, M.R. Chiaureli, V.N. Cheban, E.P. Golubev, K.V. Petrosyan, A.V. Sobolev, I.V. Zemlyanskaya
Educar para a autonomia
Authors: Andrade Paulo , Alves Raquel Mariano
Published: March 2023

Paulo Freire concebe a leitura como um ato de transgressão e prática de autonomia para a formação do pensamento crítico, que se desenvolve na relação dialógica entre leitura do mundo e leitura da palavra escrita. O presente artigo defende o papel da literatura como espaço capaz de mobilizar um campo completo de saberes e um efetivo instrumento de inovação social, à medida que contribui para o exercício da alteridade e da diversidade. Como a palavra poética, formada por um sistema específico de linguagem, que leva em conta a vivência do leitor, deve ser apresentada na sala de aula?
Uso de informações contábeis em saúde
Authors: Avelar Ewerton Alex , Avelar Eliane Apolinário Vieira
Published: March 2023

A pesquisa apresentada neste artigo visou analisar a influência da regulação do Sistema Único de Saúde (SUS) sobre as decisões e o desempenho econômico-financeiro de hospitais filantrópicos brasileiros empregando informações contábeis. Tal pesquisa pode ser classificada como quantitativa, descritiva, correlacional, ex post facto e longitudinal. Para o desenvolvimento do estudo, foram empregados dados secundários, especialmente, dados provenientes das demonstrações contábeis publicadas pelas organizações que compuseram a amostra. Também foram utilizados dados operacionais e categóricos coletados junto ao Cadastro Nacional de Estabelecimentos de Saúde (CNES) e ao Departamento de Informática do Sistema Único de Saúde (DATASUS). A amostra da pesquisa foi composta por hospitais que apresentaram seus dados contábeis e operacionais de forma pública no período de 2010 a 2015. Após a coleta e o tratamento dos dados, foram aplicadas as seguintes técnicas de análise: análise documental, estatística descritiva, teste de Kolmogorov–Smirnov, teste de Kruskal-Wallis, estatística do Qui-quadrado e análise de regressão com dados em painel. Constatou-se uma precariedade na gestão do capital de giro no caso dos hospitais filantrópicos. Ao se analisar as decisões de financiamento desses hospitais, duas variáveis de regulação se mostraram relevantes na explicação do nível de endividamento dessas organizações: a complexidade dos procedimentos e o nível de especialização. Ademais, observou-se que a maior especialização dos hospitais filantrópicos tendeu a melhorar o seu resultado em termos de criação de valor.
Cidades inteligentes, desigualdades territoriais e saúde pública
Authors: Leandro Bianca Borges da Silva
Published: March 2023

Como construir processos de cidades inteligentes que superem as desigualdades socioespaciais, em especial as desigualdades que se refletem na saúde? Esta é uma das questões que inicia este artigo no formato de ensaio crítico-reflexivo que não tem a pretensão de trazer respostas absolutas e prontas para os assuntos que se entrecruzam no questionamento elencado. Apoia-se metodologicamente na revisão narrativa da literatura com base no referencial teórico da determinação social do processo saúde-doença e na compreensão da informação em saúde como um direito. Este texto traz alguns tópicos sobre a temática das cidades inteligentes no contexto brasileiro, acrescido da discussão da saúde como direito social, democraticamente conquistado no Brasil e as interfaces necessárias com temáticas relevantes para o campo da informação em saúde. São feitas reflexões e apontamentos necessários para que a incorporação da tecnologia digital nas cidades se dê no sentido de diminuir as desigualdades territoriais e não insivibilizá-las ou agudizá-las. Para a análise reflexiva foram trazidas situações exemplos que pudessem elucidar a discussão. É necessário avançar em processos e metodologias que identifiquem as desigualdades territoriais, em especial, as que incidem na saúde, pensar em formas de uso, incorporação e adaptação das tecnologias de informação e comunicação de acordo com as heterogeneidades e necessidades locais. Fortalecendo a informação em saúde como um direito humano e a construção de saúde digital e cidades digitais inclusivas e não como barreiras de acesso.
Classificações, terminologias e ontologias no campo da saúde
Authors: Galvão Maria Cristiane Barbosa
Published: March 2023

Considerando problemas ocorridos no cenário brasileiro durante a pandemia de Covid-19, buscou-se apresentar as funcionalidades básicas de classificações, terminologias e ontologias empregadas no campo da saúde, a fim de responder as seguintes questões: Qual escopo cobrem e para que são usadas? Quais são seus elementos constituintes? Quais são seus contextos de uso? Quais profissionais as empregam? Para atingir esse objetivo e responder tais questões, desenvolveu-se um estudo descritivo a partir de documentos oficiais dessas linguagens. Descreveu-se a Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT); a Logical Observation Identifiers Names and Codes (LOINC); a Classificação Internacional de Doenças e Problemas Relacionados à Saúde (CID); a Classificação Internacional de Atenção Primária (CIAP); a Tabela de Procedimentos do Sistema Único de Saúde; a Classificação Brasileira Hierarquizada de Procedimentos Médicos (CBHPM); a Terminologia Unificada da Saúde Suplementar (TUSS); a Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF); a NANDA International Nursing Diagnoses: definitions and classification (NANDA-I); a Classificação Internacional da Prática de Enfermagem (CIPE); e os Descritores em Ciências da Saúde (DeCS). Ressalta-se que as classificações, terminologias e ontologias do campo da saúde são desenvolvidas por instituições de referência internacional e nacional. Elas apresentam escopos bem delimitados a serem empregados em situações comunicacionais bem estabelecidas seja por equipes disciplinares seja por equipes interdisciplinares. Para evitar qualquer tipo de desvio no emprego das classificações, terminologias e ontologias do campo da saúde, é fundamental que os estudantes, profissionais, gestores e pesquisadores do campo da saúde recebam formação e treinamento continuado sobre essas temáticas.
olhar biográfico sobre médicas-cultural do século XIX/XX em Portugal e no Brasil
Authors: Miranda Zeny Duarte de , Souza Salim Silva , Abreu Carmen Matos
Published: March 2023

Apresenta-se o olhar biográfico sobre médicas-cultural dos séculos XIX/XX, suas trajetórias e, inevitavelmente, contingências, relações sociais, raciais e de gênero de intelectuais médicas que viveram nos séculos XIX e XX, em Portugal e no Brasil. Quer na Bahia, Sergipe e quer noutros estados brasileiros, como também noutros países, no que concerne à disposição do leque espácio-temporal, a presença de médicas está infimamente aqui representadas, com similitudes suportadas pelas biografias das primeiras estudantes formadas em Medicina, em ambos os países. A partir de então, inicia-se o surgimento de protagonistas da Medicina (Ciência), assim como das demais áreas, a exemplo de mulheres-cultural com invariáveis produções na Literatura, Artes, Política, Cultura, Religião, Ciências Sociais e nas Humanidades em geral. Este estudo é originário do projeto Os médicos e a cultura: estudo crítico e guia geral dos arquivos de médicos escritores, artistas e pensadores de Portugal e Bahia - Brasil, iniciado em 2006, ainda em desenvolvimento, com abordagens sobre a existência de médicos e médicas que se permitem buscar motivações noutras atividades, paralelas e/ou simultâneas, fora da profissão. Todavia, reconheça-se, somente a partir do ano 2006 é que surge o interesse sobre a temática em foco, investigada no âmbito de Portugal e da Bahia, à luz da Ciência da Informação (CI), esta rica área de multidisciplinaridade, com enfoque no tratamento e gestão da informação e do conhecimento. Com o alargamento desta pesquisa, observou-se a quase inexistência de literatura sobre médicas-cultural, protagonistas sociais, representantes da intelligentsia.
jornalismo científico como agente de aproximação entre a ciência e a sociedade
Authors: Cunha Edna Carvalho da , Santos da Silva Zaqueu Jhônathas , Santos Magnólia Rejane Andrade dos
Published: March 2023

O presente artigo trata do jornalismo científico e da sua importância como agente de aproximação na propagação da ciência e no que tange à relação entre público leigo e resultados de pesquisas científicas. Longe de esgotar o assunto, o estudo não tem a pretensão de ser conclusivo, mas objetiva mostrar que este ramo do jornalismo contribui na propagação da informação científica de modo a esclarecer o usuário da informação sobre resultados de produções científicas, os impactos que estas causam e os benefícios que elas podem trazer com sua aplicabilidade. A repercussão de assuntos ligados à pesquisa científica através do jornalismo científico também é abordada no artigo, usando como exemplo as informações jornalísticas sobre a polêmica entre os cientistas Luc Montaigner do Instituto Pasteur na França e Robert Charles Gallo do Instituto Nacional de Saúde, que na década de 80 disputaram a descoberta do Vírus da Imunodeficiência Humana – HIV (AIDS). A metodologia do trabalho consistiu em pesquisas bibliográfica e hemerográfica a fim de munir o estudo com pertinentes informação sobre o tema.
função do bibliotecário de referência nas revisões de literatura em ciências da saúde o
Authors: Unger Roberto
Published: March 2023

O bibliotecário de referência é o profissional da informação habilitado para atendimento ao usuário e suporte à pesquisa, este papel ganha contornos estratégicos com a intensidade da demanda das necessidades informacionais, a atualização e capacitação profissional dos usuários frente ao cenário das tecnologias da informação e comunicação. Destaca a atuação deste profissional na área das ciências da saúde como agente educador incorporando sua habilidade na estratégia de busca e recuperação da informação em fontes de informação especializadas para apoio na educação continuada. Apresenta alternativa de método e técnica de estudo na elaboração de revisão da literatura para o aprimoramento profissional.
Supersus covid
Authors: Sousa Islândia Maria Carvalho de , Barbosa Fernanda Elizabeth Sena , Siebra Sandra de Albuquerque , Farias Lays Hevércia Silveira de , Gomes Elainne Christine de Souza , Bezerra Adriana Falangola Benjamin , Aquino Camilla Maria Ferreira
Published: March 2023

O presente artigo é um relato de experiência descritivo e qualitativo, que teve como objetivo descrever o processo de construção colaborativa do jogo digital SuperSUSCovid, desenvolvido durante a pandemia da Covid-19, devido à necessidade de produzir recursos educacionais tecnológicos que possibilitassem a disseminação científica sobre a Covid-19, com ênfase nas principais ações de enfrentamento promovidas pelo Sistema Único de Saúde (SUS). Adicionalmente, são apontados inspirações e desafios do trabalho interdisciplinar, para produzir um recurso educacional destinado à valorização do maior sistema de saúde público e universal - o SUS.
COVID Vaccines vs. Viral Evolution: Who Will Win the Battle?
Authors: Sharma Sahil , Sood Vikas , Sharma Deepak
Published: March 2023

The emergence of new variants seems to perpetually prolong the COVID-19 pandemic. On top of that, the waning of vaccine protection is further thwarting our efforts to end it. Our article discusses the incessant question raging in everybody’s mind: Are we ever going to win?
MiRNAs Overexpression and Their Role in Breast Cancer: Implications
for Cancer Therapeutics
Authors: Lee Sau Har , Ng Chu Xin , Wong Sharon Rachel , Chong Pei Pei
Published: March 2023

MicroRNAs have a plethora of roles in various biological processes in the cells and
most human cancers have been shown to be associated with dysregulation of the expression of miRNA
genes. MiRNA biogenesis involves two alternative pathways, the canonical pathway which requires
the successful cooperation of various proteins forming the miRNA-inducing silencing complex
(miRISC), and the non-canonical pathway, such as the mirtrons, simtrons, or agotrons pathway,
which bypasses and deviates from specific steps in the canonical pathway. Mature miRNAs
are secreted from cells and circulated in the body bound to argonaute 2 (AGO2) and miRISC or
transported in vesicles. These miRNAs may regulate their downstream target genes via positive or
negative regulation through different molecular mechanisms. This review focuses on the role and
mechanisms of miRNAs in different stages of breast cancer progression, including breast cancer
stem cell formation, breast cancer initiation, invasion, and metastasis as well as angiogenesis. The
design, chemical modifications, and therapeutic applications of synthetic anti-sense miRNA oligonucleotides
and RNA mimics are also discussed in detail. The strategies for systemic delivery
and local targeted delivery of the antisense miRNAs encompass the use of polymeric and liposomal
nanoparticles, inorganic nanoparticles, extracellular vesicles, as well as viral vectors and viruslike
particles (VLPs). Although several miRNAs have been identified as good candidates for the design
of antisense and other synthetic modified oligonucleotides in targeting breast cancer, further efforts
are still needed to study the most optimal delivery method in order to drive the research beyond
preclinical studies.
Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and
Experimental Approaches
Authors: Mares Catalina , Udrea Ana-Maria , Buiu Catalin , Staicu Angela , Avram Speranta
Published: March 2023

Compounds from plants that are used in traditional medicine may have medicinal properties.
It is well known that plants belonging to the genus Aconitum are highly poisonous. Utilizing
substances derived from Aconitum sp. has been linked to negative effects. In addition to their toxicity,
the natural substances derived from Aconitum species may have a range of biological effects on
humans, such as analgesic, anti-inflammatory, and anti-cancer characteristics. Multiple in silico, in
vitro, and in vivo studies have demonstrated the effectiveness of their therapeutic effects. In this review,
the clinical effects of natural compounds extracted from Aconitum sp., focusing on aconitelike
alkaloids, are investigated particularly by bioinformatics tools, such as the quantitative structure-
activity relationship method, molecular docking, and predicted pharmacokinetic and pharmacodynamic
profiles. The experimental and bioinformatics aspects of aconitine’s pharmacogenomic
profile are discussed. Our review could help shed light on the molecular mechanisms of Aconitum
sp. compounds. The effects of several aconite-like alkaloids, such as aconitine, methyllycacintine, or
hypaconitine, on specific molecular targets, including voltage-gated sodium channels, CAMK2A
and CAMK2G during anesthesia, or BCL2, BCL-XP, and PARP-1 receptors during cancer therapy,
are evaluated. According to the reviewed literature, aconite and aconite derivatives have a high affinity
for the PARP-1 receptor. The toxicity estimations for aconitine indicate hepatotoxicity and
hERG II inhibitor activity; however, this compound is not predicted to be AMES toxic or an hERG I
inhibitor. The efficacy of aconitine and its derivatives in treating many illnesses has been proven
experimentally. Toxicity occurs as a result of the high ingested dose; however, the usage of this
drug in future research is based on the small quantity of an active compound that fulfills a therapeutic
role.
Overcoming the Limitations of Therapeutic Strategies to Combat Pancreatic
Cancer using Nanotechnology
Authors: Dhoundiyal Shivang , Alam Md. Aftab
Published: March 2023

Resistance to conventional antitumour therapies and Hypoxia in patients with advanced
solid tumours are two major reasons for the failure of conventional anti-tumour therapies. Therefore,
it is important to find a new therapeutic method that can overcome these problems. An attenuated anaerobic
bacterium, Clostridium novyi-NT, could target Hypoxic and Necrotic areas of tumours causing
tumour lysis and stimulating a host anti-tumour immune response. To the best of our knowledge,
the combination of bacterial anti-tumour therapy, chemotherapy, radiotherapy and immunotherapy
may promote tumour regression, inhibit metastasis and develop a new strategy for the treatment of
solid tumours. However, the possible molecular mechanisms of the combined therapies are still the
biggest challenge. This review provides an overview of the history of bacterial cancer therapy and the
development of a non-lethal strain of Clostridium novyi. Below is a precise definition of Hypoxic
conditions in solid tumour tissue. To understand the anticancer effect of Clostridium novyi-NT spores,
possible cell death mechanisms were summarised by the enzyme phospholipase C (nt01cx0979),
which is secreted by Clostridium novyi-NT spores after germination in tumour tissue. The function of
Clostridium novyi-NT spores in stimulating the host immune system to elicit anti-tumour responses
was reviewed. Then, the results of anti-tumour combination therapies based on Clostridium novyi-NT
spores were compiled. Identifying the molecular mechanisms of Clostridium novyi-NT in treating tumours
and inducing cell death in invasive cancer cells, ultimately leading to tumour regression, may
develop promising clinical strategies in the combined treatment of solid tumours.
Recent Advancements in Light-responsive Supercapacitors
Authors: Shah Syed Shaheen , Aziz Md. Abdul
Published: March 2023

With so many of our daily activities related to electricity, from telecommunication to
laptops and computers, the use of electric energy has skyrocketed in today's technology-based
world. Energy output must rise to meet rising energy demand. Still, as fossil fuels are running
out, we must turn to more renewable energy sources, particularly solar energy, which can be
harnessed and converted to electricity by solar-powered cells. The issues, however, are brought
about by the sunlight's unpredictable energy output. The energy produced by solar cells should
therefore be stored using energy storage technologies. This notion led to the development of the
photo-supercapacitor, a device that combines a solar cell with a supercapacitor to store the energy
generated by the solar cells. However, recently researchers developed light-responsive materials
for supercapacitors that could be used directly as electrode materials and deposited on various
transparent and conductive substrates. Such light-responsive supercapacitors could be operated
directly by shining solar light without using any solar cell. A light-responsive supercapacitor's
efficiency is primarily influenced by the active materials used in its electrode fabrication.
The main components of high-energy conversion, which improves a light-responsive supercapacitor's
performance and shelf life, are photoactive materials, counter electrodes, compatible
electrolytes, and transparent substrate performances. Furthermore, light-responsive supercapacitors
are cutting-edge and promising energy storage devices that can self-charge under light illumination
by converting light to electrical energy and storing it for later use. They are considered
a novel approach to energy issues in electrical transportation, electronic equipment, and on-chip
energy storage devices. Thus, this review paper opens up an avenue for the direct utilization of
photoactive nanomaterials for electrochemical energy storage and demonstrates the substantial
potential for the fabrication of advanced light-responsive supercapacitors. This study also covers
the fundamentals of how this exciting field works, the historical trajectory of how far it has
come, and the promising prospects for its future.
The Sustained-released Polylactic Co-glycolic Acid Nanoparticles Loaded
with Chlorhexidine as Antibacterial Agents Inside the Dental Implant
Fixture
Authors: Dizaj Solmaz Maleki , Memar Mohammad Yousef , Mosayebzadeh Amin , Ghavimi Mohammad Ali
Published: March 2023

Introduction:

Titanium-based implants are widely used due to their good biocompatibility
and high corrosion resistance. Infections after implant placement are the main reason for the failure of
implant treatment. Some recent studies have also shown that microbial contamination can occur at the
implant-abutment level in implants with healthy or diseased surrounding tissue. The purpose of this
study is to investigate the antibacterial effect of slow-release nanoparticles of polylactic co-glycolic acid
(PLGA) loaded with chlorhexidine (CHX) inside the implant fixture.

Materials and Methods:

Thirty-six implants in three groups were examined in the bacterial culture environment.
In the first group, PLGA/CHX nanoparticles; in the second group, the negative control
group (distilled water) and in the third group, the positive control groups (chlorhexidine) were used. The
bacterial suspensions, including Escherichia coli ATCC: 25922, Staphylococcus aureus ATCC: 6538
and Enterococcus faecalis ATCC: 29212 were used to investigate the antimicrobial effect of the prepared
nanoparticles.

Results:

The results showed that the use of PLGA/CHX nanoparticles significantly inhibited the growth
of all three bacteria. Nanoparticles loaded with chlorhexidine had a significant decrease in the growth
rate of all three bacteria compared to chlorhexidine and water. The lowest bacterial growth rate was observed
in the Enterococcus faecalis/PLGA nanoparticles group, and the highest bacterial growth rate
was observed in the Staphylococcus aureus/H2O group.

Conclusion:

The current study showed that the use of PLGA/CHX nanoparticles could significantly inhibit
the growth of all three bacteria. Of course, the current study was conducted in vitro, and to obtain
clinical results, we need to conduct a study on human samples. In addition, the results of this study
showed that the chemical antimicrobial materials could be used in low concentrations and in a sustained-
released manner in cases of dealing with bacterial infections, which can lead to better and targeted
performance as well as reduce possible side effects.
Work commitment based on Islamic work ethic of Madrasah teachers in the border area in Sambas Regency
Authors: Fauzan Rizky , Hendri Irfani , Ridwansyah Ridwansyah , Kakis Maria Khristiana l , Komari Nurul
Published: March 2023

To train children in border areas of remote, impoverished countries, teachers are at the vanguard of knowledge dissemination. Diverse sectors work together to improve educational standards. The commercial, faith-based sector and the public sector and educational institutions participate in this action. The selection method used in this study was stratified random sampling. More precisely, data analysis involves scoring, coding, and tabulating questionnaire data before conducting inferential statistical analysis using Structural Equation Modeling with a Partial Least Square Approach (SEM-PLS) with the help of SmartPLS software packages version 3.3.3. The result is that in the border area, the Islamic work ethic primarily influences the commitment of madrasah instructors. They continue to provide the best guidance they can, even under trying circumstances. The idea that instructors' commitment to their work is based on the Islamic work ethic as it is applied in Islamic-based education is also supported by multiple variable models. According to the Quran and Hadith, teaching is equivalent to praying because of the teacher's commitment. This commitment continues to encourage a work mentality in outlying areas so that the level of education can be maintained.