bluuebunny/crossref_metadata_2025 huggingface dataset:
Detecting unique analyte-specific radio frequency spectral responses in liquid solutions -- implications for non-invasive physiologic monitoring
Authors: Klyve Dominic , Bosua Phil , Somers Virend , Anderson James
Published: May 2023

With rising healthcare costs and the rapid increase in remote physiologic monitoring and care delivery, there is increasing need for economical, accurate and non-invasive continuous measures of blood analytes. Based on radio-frequency identification (RFID), we have developed a novel electromagnetic platform technology (the Bio-RFID platform) to non-invasively penetrate inanimate surfaces, capture data from individual radio frequencies, and convert those data into physiologically meaningful information and insights. Here we describe ground-breaking proof-of-principle studies using Bio-RFID to accurately measure various concentrations of analytes in deionized water. The in vitro Bio-RFID platform consists of an acrylic cuvette in the shape of a 4 inch x 4 inch x 8 inch rectangular prism mounted on the Bio-RFID sensor. This apparatus is in turn mounted on a balance that allows the determination of the mass of the analyte being scanned to within 0.1g. The hardware scans through several thousand radio frequencies and sends the data to proprietary software running on a laptop computer. The software displays a spectral scan known as the Bio-RFID signature of the analyte and computes a similarity metric to compare different signatures.We tested the hypothesis that the Bio-RFID platform is able to precisely and non-invasively measure and identify a variety of analytes in vitro. For this assessment, varying solutions of 1) water in isopropyl alcohol; 2) salt in water; and 3) commercial bleach in water were tested, using a randomized double-blind trial design, as proxies for biochemical solutions in general. The Bio-RFID technology was able to detect concentrations of 2000 parts per million (ppm), with evidence suggesting the ability to detect considerably smaller concentration differences. The novel application of a Bio-RFID electromagnetic platform technology accurately detects, measures, and quantifies specific molecules in liquid. While these findings have in vitro commercial applications, these proof-of-principle studies provide strong support for the application of Bio-RFID technology for non-invasive bio-monitoring of physiologically and medically relevant analytes, such as alcohol and glucose, in the human body.

These studies were funded by a grant from Know Labs to Mayo Clinic. PB and JHA are employed by Know Labs. VKS and Mayo Clinic acknowledge a financial interest in Know Labs.

This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
Use of compensatory reserve measurements to reassess the sensitivity and specificity of the shock index for early and accurate detection of reduced central blood volume status
Authors: Convertino Victor , Thompson Patrick , Koons Natalie , Le Tuan , Lanier Jeffrey , Cardin Sylvain
Published: May 2023

Background: Shock index (SI) equals the ratio of heart rate (HR) to systolic blood pressure (SBP) with clinical evidence that it is more sensitive for trauma patient status assessment and prediction of outcome compared to either HR or SBP alone. We used lower body negative pressure (LBNP) as a human model of central hypovolemia and compensatory reserve measurement (CRM) validated for accurate tracking of reduced central blood volume to test the hypotheses that SI: 1) presents a late signal of central blood volume status; 2) displays poor sensitivity and specificity for predicting the onset of hemodynamic decompensation; and 3) cannot identify individuals at greatest risk for the onset of circulatory shock. Methods: We measured HR, SBP and CRM in 172 human subjects (19 to 55 years) during progressive LBNP designed to determine tolerance to central hypovolemia as a model of hemorrhage. Subjects were subsequently divided into those with high (HT; n = 118) and low (LT; n = 54) tolerance based on completion of 60 mmHg LBNP. The time course relationship between SI and CRM was determined and Receiver Operating Characteristic (ROC) Area Under the Curve (AUC) was calculated for sensitivity and specificity of CRM and SI to predict hemodynamic decompensation using clinically defined thresholds of 40% for CRM and 0.9 for SI. Results: The time and level of LBNP required to reach a SI = 0.9 (~60 mmHg LBNP) was significantly greater (P < 0.001) compared to CRM that reached 40% at ~40 mmHg LBNP. SI did not differ between HT and LT subjects at 45 mmHg LBNP levels. ROCAUC for CRM was 0.95 (95%CI = 0.94-0.97) compared to 0.91 (0.89-0.94) for SI (P = 0.0002). Conclusions: Despite high sensitivity and specificity, SI delays time to detect reductions in central blood volume with failure to distinguish individuals with varying tolerances to central hypovolemia.

This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
Plant-Based Additivities Improved the Growth Performance and Immune Response, and Mitigated the Inflammatory Signalling in Channel Catfish Fed a High-Fat Diet
Authors: Desouky Hesham Eed , Jiang Guang-zhen , Abasubong Kenneth Prudence , Dai Yong-Jun , Yuan Xiangyang , Adjoumani Jean-Jacques Y. , Liu Wen-bin
Published: May 2023

This study was conducted to understand the effects of glycyrrhetinic acid, berberine, and resveratrol on growth and inflammatory signalling in channel catfish fed a high-fat diet (HFD). Fish (average weight, 20 ± 0.15 g) were distributed randomly in 15 tanks (11 fish per tank). Fish were allocated randomly to five experimental diets: (control diet (ND); high-fat diet (HFD); high-fat diet + 0.3 mg/kg glycyrrhetinic acid (HFD + GA); high-fat diet + 50 mg/kg berberine (HFD + B); and high-fat diet + 400 mg/kg resveratrol (HFD + R). Each diet was tested in triplicates for eight weeks. The final body weight (FBW), body weight gain (BWG), specific growth rate (SGR), and condition factor (CF) were significantly lower in fish fed HFD. In contrast, opposite trends were observed in the feed conversion ratio (FCR), hepatosomatic index (HSI), visceralsomatic index (VSI), and mesenteric fat index (MFI). Fish fed HFD showed a higher trend (

P
<
0.05

) in plasma glucose, cortisol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), liver total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL), while opposite trends were found in total protein (TP) and high-density lipoprotein (HDL). These parameters were all enhanced by feeding the additive-supplemented diets. Liver superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), plasma lysozyme (LYM), myeloperoxidase (MPO), alkaline phosphatase (AKP), acid phosphatase (ACP) activities, and immunoglobulin M (IgM) levels were all lower in fish fed HFD as compared to the control group. However, supplementing GA, berberine, and resveratrol restored these parameters to similar levels to the control group. Upregulated gene expression of interleukin 1β (IL-1ß), nitric oxide (NOS), nuclear factor-kappa B (NF-κB), X box-binding protein 1 (XBP1s), coupled with tumour necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ), was observed in fish fed HFD, whereas reverse trends were observed in the additive-supplemented groups as compared to the control group. Overall, glycyrrhetinic acid, berberine, and resveratrol could reduce endoplasmic reticulum stress and inflammation and enhance the immune response in channel catfish fed HFD.
A Bottom-Up Approach to PV System Design for Rural Locality Electrification: A Case Study in Burkina Faso
Authors: Bonkoungou Dominique , Tassembédo Sosthène , Zongo Sidiki , Koalaga Zacharie
Published: May 2023

This work evaluates the performance of optimal hybrid PV/battery and PV/diesel generator renewable energy systems for a remote village in Burkina Faso. Based on socioeconomic data and the household sample survey, a technoeconomic simulation and optimization model of electrical loading are presented. Ant colony optimization (ACO) and the loss of power supply probability (LPSP) algorithms were used for the search of the optimal hybrid power system. For the selected village location, the results have shown that the hybrid PV/battery system represents the best renewable energy solution due to abundant solar irradiation and carbon emission free compared to the conventional diesel generator (DG) or PV/DG system. To reach the estimated load power demand of 2150 kWh for the studied location, optimized PV/battery configuration sizing required 650 PV modules of 250 W and 715 batteries of 300 Ah. The economical evaluation reveals a cost investment of about 1,293 025.7 USD for a lifetime of 25 years in comparison of that of PV/DG and DG systems, which are 1,088 701.9 USD and 1,682 850.6 USD, respectively. However, environmental and atmospheric pollution is minimized with a saving of more than 17943 tons of CO2. Therefore, the production of electricity from the PV/battery system leads to better competitiveness reliability for a socioeconomic development of studied remote villages.
Soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares no município de São Paulo, 2020
Authors: Kamioka Gabriela Akemi , Madalosso Geraldine , Albuquerque José Olimpio Moura de , Costa Selma Anequini , Ferreira Paula Bisordi , Sato Ana Paula Sayuri , Glasser Paula Regina , Pino Francisco Alberto , Burihan Patrícia Carla Piragibe Ramos , Carvalho Ana Carolina Aguiar de , Amorim Ana Beatriz Pagliaro , Cavazzana Cinthya Luzia , Aires Caroline Cotrim , Kataoka Ana Paula Arruda Geraldes , Savani Elisa San Martin Mouriz , Bessa Thirsa Alvares Franco , Aguiar Breno Souza de , Failla Marcelo Antunes , Santos Edson Aparecido dos , Brito Edjane Maria Torreão , Santos Maria Cristina Honório dos , Caldeira Luiz Artur Vieira , Saboia e Silva Solange Maria , Zamarco Luiz Carlos , Fonseca Sandra Maria Sabino , Lima Marcia Maria de Cerqueira , Marques Ivanilda Argenau , Mauro Athenê Maria de Marco França , Masi Eduardo de
Published: May 2023

OBJETIVO: Estimar a soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares de quatro a 14 anos de idade residentes no município de São Paulo, segundo variáveis clínicas, demográficas, epidemiológicas e sociais, durante o período de fechamento das escolas como medida de controle da covid-19. MÉTODOS: Realizou-se um inquérito sorológico em setembro de 2020 com amostra aleatória estratificada por tipo de rede de ensino (pública municipal, pública estadual e privada). Foi coletada amostra de sangue venoso utilizando-se o teste de imunoensaio de fluxo lateral da fabricante Wondfo para detecção de anticorpos totais contra o vírus SARS-CoV-2. Aplicaram-se questionários semiestruturados para o levantamento de dados clínicos, demográficos, sociais e epidemiológicos. RESULTADOS: A soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares foi de 16,6% (IC95% 15,4–17,8). O estudo encontrou soroprevalências mais elevadas na rede pública municipal (18,5%; IC95% 16,6–20,6) e estadual (16,2%; IC95% 14,4–18,2) em relação à rede privada (11,7; IC95% 10,0–13,7) e entre escolares da raça/cor preta e parda (18,4%; IC95% 16,8–20,2) e no estrato social mais vulnerável (18,5%; IC95% 16,9–20,2). A pesquisa identificou menores soroprevalências nos escolares que relataram seguir as medidas recomendadas de proteção contra a covid-19. CONCLUSÃO: A soroprevalência de anticorpos contra o vírus SARS-CoV-2 atinge principalmente os escolares socialmente mais vulneráveis. Este estudo pode contribuir para embasar políticas públicas que reforcem a importância da suspensão das aulas presenciais e da necessidade de estratégias de medidas de proteção e acompanhamento do status sorológico daqueles que ainda não foram contemplados no calendário vacinal.
Centros Especializados em Reabilitação (CER) no SUS e o impacto da pandemia de covid-19
Authors: Suda Bianca Tomi Rocha , Mota Paulo Henrique dos Santos , Bousquat Aylene
Published: May 2023

OBJETIVO: Analisar o impacto da pandemia de covid-19 no funcionamento dos Centros Especializados em Reabilitação (CER) no SUS. MÉTODOS: Realizou-se análise da variação da produção ambulatorial dos CER com base nos dados do Sistema de Informações Ambulatoriais do Sistema Único de Saúde (SIA-SUS) no período de março de 2019 a dezembro de 2021. Tais resultados foram cotejados com as percepções de gestores de CER acerca dos impactos da pandemia nas unidades, aferidas por websurvey aplicado entre novembro de 2020 e fevereiro de 2021. Foram calculadas as médias mensais de 247 procedimentos, organizados em 18 grupos, para três períodos – ano anterior à pandemia (APP), primeiro (AP1) e segundo (AP2) anos de pandemia. Por meio do formulário on-line foram coletadas informações sobre: funcionamento e organização dos serviços; reabilitação pós-covid-19; ações de apoio às necessidades de usuários e profissionais; estratégias e desafios vivenciados. RESULTADOS: Houve redução de 33,3% do total de procedimentos em AP1 em relação a APP. Não foram reduzidos procedimentos realizados por enfermeiros e para pessoas ostomizadas. Ocorreu maior prejuízo para atividades em grupo, terapias visuais e visitas domiciliares. Em AP2, houve recuperação das médias em relação a APP em 11 grupos de procedimentos, com aumento de 104,1% de Fisioterapia Cardiorrespiratória. Nas respostas ao formulário on-line, 91,7% dos gestores indicam mudanças estruturais e/ou organizacionais nos CER como: criação de critérios de priorização para atendimentos; introdução de telerreabilitação; modificações no processo de trabalho e; disponibilização de capacitações profissionais. Metade dos CER já atendiam pessoas com sequelas de covid-19, mas nem todos haviam sido instrumentalizados para tanto. Identificaram-se limitações na participação e no suporte social para PCD. CONCLUSÕES: Houve severo impacto da pandemia de covid-19 nos CER. Ao represamento de demandas prévias se somam aquelas de usuários pós-covid-19, configurando um quadro desafiador. Faz-se necessário fortalecimento da Rede de Cuidados à Pessoa com Deficiência, com ampliação e maior integração dos serviços e organização mais inclusiva para a superação desses desafios.
A new species of Lepidodactylus (Squamata: Gekkonidae) from Umboi Island, Papua New Guinea
Authors: KRAUS FRED , VAHTERA VARPU , WEIJOLA VALTER
Published: May 2023

We describe a new species of Lepidodactylus from Umboi Island, just to the west of New Britain. It is a member of the Lepidodactylus guppyi Group and can be distinguished from all other Melanesian Lepidodactylus by aspects of digital scalation, digital webbing, enlarged femoral/precloacal scales, and color pattern. It is genetically distinct from its closest congeners, and genetic and morphological data indicate that the new species is most similar among named species to Lepidodactylus guppyi from the Solomon Islands, but it diverged from this species and other close relatives approximately 8 MYA or longer at a time prior to the existence of the island that it now occupies. The new species is known from only three individuals collected on a single tree, and efforts to find more animals in what seemed good habitat nearby were unsuccessful. This duplicates the pattern of apparent rarity seen for many Lepidodactylus species. Sufficient habitat exists on Umboi Island for arboreal geckos, suggesting that the species is not actually endangered but is ecologically cryptic. However, lack of needed information leads us to assess this species’ conservation status as Data Deficient.
New record of Trichopeltarion dextrum (Rathbun, 1898) (Brachyura: Trichopeltariidae) from Brazil
Authors: VIANA GIRLENE FÁBIA SEGUNDO , SILVA KÁTIA C. A. , CINTRA ISRAEL HIDENBURGO ANICETO , SOUZA-FILHO JESSER F.
Published: May 2023

Trichopeltarion dextrum (Rathbun, 1898) is herein reported from the first time from Northern Brazil. The specimens were captured using the shrimp trawls during the REVIZEE–Score Program. Six specimens, being two males and four females, were examined. The material fits well with diagnostic characters of T. dextrum, but the males have the carapace almost as long as wide, while in the type material, is slightly longer the wide. This is the second species of the genus Trichopeltarion reported from Brazilian waters.
THE REPUBLICAN TRUMP VOTER
Authors: Arhin Kofi , Stockemer Daniel , Normandin Marie‐Soleil
Published: May 2023

With its emphasis on anti‐immigration rhetoric and actions, protectionism, as well as populism, Donald Trump has transformed the Republican Party into a party that closely resembles populist radical right‐wing parties in Europe. In this article, we first illustrate how the Republican Party has transformed into a radical right‐wing party. Second, we examine the degree to which the Trump voter has the same or similar characteristics as the prototypical radical right‐wing voter. To do so, we compare some key features of voters for the Alternative for Germany (AfD) and Trump voters. Through original survey research, we find that the two voter types are alike. Both AfD and Trump voters espouse anti‐immigrant sentiment, reject globalization, and position themselves on the right on a left‐right ideological scale. This implies that, both from a supply and demand side perspective, the Trump Republican Party has become a prototypical radical right‐wing party.
Quantitative multiplex real-time polymerase chain reaction assay for the detection of Helicobacter pylori and clarithromycin resistance
Authors: Kim Ilsoo , Maeng Lee-So , Kim Joon Sung , Kim Byung-Wook , Cheung Dae Young , Kim Jin Il , Park Soo-heon
Published: May 2023

Background

Identifying clarithromycin resistance is essential for eradicating Helicobacter pylori (HP). Therefore, we evaluated the performance of Allplex™ H.pylori & ClariR Assay (Allplex™) for diagnosing and detecting clarithromycin resistance in HP.

Methods

Subjects who underwent esophagogastroduodenoscopy between April 2020 and August 2021 at Incheon St. Mary’s hospital were enrolled in this study. The diagnostic performances of Allplex™ and dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) were compared with sequencing as the gold standard.

Results

A total of 142 gastric biopsy samples were analyzed. Gene sequencing revealed 124 HP infections, 42 A2143G mutations, 2 A2142G mutations, one dual mutation, and no A2142C mutation. DPO-PCR showed 96.0% sensitivity and 100.0% specificity for HP detection; the corresponding rates for Allplex™ were 99.2% and 100.0%. DPO-PCR showed 88.3% sensitivity and 82.0% specificity for A2143G mutation, and Allplex™ showed 97.6% and 96.0%. The Cohen’s Kappa coefficient for overall test results was 0.56 for DPO-PCR and 0.95 for Allplex™.

Conclusion

Allplex™ showed comparable diagnostic performance with direct gene sequencing and non-inferior diagnostic performance to DPO-PCR. Further research is required to confirm whether Allplex™ is an effective diagnostic tool for the eradication of HP.
Ketamine versus etomidate for rapid sequence intubation in patients with trauma: a retrospective study in a level 1 trauma center in Korea
Authors: Kim Jinjoo , Jung Kyoungwon , Moon Jonghwan , Kwon Junsik , Kang Byung Hee , Yoo Jayoung , Song Seoyoung , Bang Eunsook , Kim Sora , Huh Yo
Published: May 2023

Background

Ketamine and etomidate are commonly used as sedatives in rapid sequence intubation (RSI). However, there is no consensus on which agent should be favored when treating patients with trauma. This study aimed to compare the effects of ketamine and etomidate on first-pass success and outcomes of patients with trauma after RSI-facilitated emergency intubation.

Methods

We retrospectively reviewed 944 patients who underwent endotracheal intubation in a trauma bay at a Korean level 1 trauma center between January 2019 and December 2021. Outcomes were compared between the ketamine and etomidate groups after propensity score matching to balance the overall distribution between the two groups.

Results

In total, 620 patients were included in the analysis, of which 118 (19.9%) were administered ketamine and the remaining 502 (80.1%) were treated with etomidate. Patients in the ketamine group showed a significantly faster initial heart rate (105.0 ± 25.7 vs. 97.7 ± 23.6, p = 0.003), were more hypotensive (114.2 ± 32.8 mmHg vs. 139.3 ± 34.4 mmHg, p < 0.001), and had higher Glasgow Coma Scale (9.1 ± 4.0 vs. 8.2 ± 4.0, p = 0.031) and Injury Severity Score (32.5 ± 16.3 vs. 27.0 ± 13.3, p < 0.001) than those in the etomidate group. There were no significant differences in the first-pass success rate (90.7% vs. 90.1%, p > 0.999), final mortality (16.1% vs. 20.6, p = 0.348), length of stay in the intensive care unit (days) (8 [4, 15] (Interquartile range)), vs. 10 [4, 21], p = 0.998), ventilator days (4 [2, 10] vs. 5 [2, 13], p = 0.735), and hospital stay (days) (24.5 [10.25, 38.5] vs. 22 [8, 40], p = 0.322) in the 1:3 propensity score matching analysis.

Conclusion

In this retrospective study of trauma resuscitation, those receiving intubation with ketamine had greater hemodynamic instability than those receiving etomidate. However, there was no significant difference in clinical outcomes between patients sedated with ketamine and those treated with etomidate.
Extrapolating empirical long-term survival data: the impact of updated follow-up data and parametric extrapolation methods on survival estimates in multiple myeloma
Authors: Bakker LJ , Thielen FW , Redekop WK , Groot CA Uyl-de , Blommestein HM
Published: May 2023

Background

In economic evaluations, survival is often extrapolated to smooth out the Kaplan-Meier estimate and because the available data (e.g., from randomized controlled trials) are often right censored. Validation of the accuracy of extrapolated results can depend on the length of follow-up and the assumptions made about the survival hazard. Here, we analyze the accuracy of different extrapolation techniques while varying the data cut-off to estimate long-term survival in newly diagnosed multiple myeloma (MM) patients.

Methods

Empirical data were available from a randomized controlled trial and a registry for MM patients treated with melphalan + prednisone, thalidomide, and bortezomib- based regimens. Standard parametric and spline models were fitted while artificially reducing follow-up by introducing database locks. The maximum follow-up for these locks varied from 3 to 13 years. Extrapolated (conditional) restricted mean survival time (RMST) was compared to the Kaplan-Meier RMST and models were selected according to statistical tests, and visual fit.

Results

For all treatments, the RMST error decreased when follow-up and the absolute number of events increased, and censoring decreased. The decline in RMST error was highest when maximum follow-up exceeded six years. However, even when censoring is low there can still be considerable deviations in the extrapolated RMST conditional on survival until extrapolation when compared to the KM-estimate.

Conclusions

We demonstrate that both standard parametric and spline models could be worthy candidates when extrapolating survival for the populations examined. Nevertheless, researchers and decision makers should be wary of uncertainty in results even when censoring has decreased, and the number of events has increased.
Implementation of continuous-wave Doppler ultrasound to detect the high-risk foetus in the low-risk mother: lessons from South Africa
Authors: Hlongwane Tsakane M.A.G. , Pattinson Robert C. , Bergh Anne-Marie
Published: May 2023

Introduction

Detecting the risk of stillbirth during pregnancy remains a challenge. Continuous-wave Doppler ultrasound (CWDU) can be used to screen for placental insufficiency, which is a major cause of stillbirths in low-risk pregnant women. This paper describes the adaptation and implementation of screening with CWDU and shares critical lessons for further rollout. Screening of 7088 low-risk pregnant women with Umbiflow™ (a CWDU device) was conducted in 19 antenatal care clinics at nine study sites in South Africa. Each site comprised a catchment area with a regional referral hospital and primary healthcare antenatal clinics. Women with suspected placental insufficiency as detected by CWDU were referred for follow-up at the hospital. A 35–43% reduction in stillbirths was recorded.

Methods

The authors followed an iterative reflection process using the field and meeting notes to arrive at an interpretation of the important lessons for future implementation of new devices in resource-constrained settings.

Results

Key features of the implementation of CWDU screening in pregnancy combined with high-risk follow-up are described according to a six-stage change framework: create awareness; commit to implement; prepare to implement; implement; integrate into routine practice; and sustain practice. Differences and similarities in implementation between the different study sites are explored. Important lessons include stakeholder involvement and communication and identifying what would be needed to integrate screening with CWDU into routine antenatal care. A flexible implementation model with four components is proposed for the further rollout of CWDU screening.

Conclusions

This study demonstrated that the integration of CWDU screening into routine antenatal care, combined with standard treatment protocols at a higher-level referral hospital, can be achieved with the necessary resources and available maternal and neonatal facilities. Lessons from this study could contribute to future scale-up efforts and help to inform decisions on improving antenatal care and pregnancy outcomes in low- and middle-income countries.
Experiences of childbirth care among immigrant and non-immigrant women: a cross-sectional questionnaire study from a hospital in Norway
Authors: Reppen Kristin , Henriksen Lena , Schei Berit , Magnussen Elisabeth Balstad , Infanti Jennifer Jean
Published: May 2023

Background

Immigrant women have higher risks for poor pregnancy outcomes and unsatisfactory birth experiences than the general population. The mechanisms behind these associations remain largely unknown, but they may result from differential care provided to immigrant women or unsatisfactory interactions with health providers. This study aimed to investigate immigrant and non-immigrant women's experiences of health care during childbirth, particularly assessing two dimensions: perceived general quality of care and attainment of health care needs during childbirth.

Methods

This was a cross-sectional study carried out over 15 months in 2020 and 2021, and data were collected from a self-completed questionnaire. The labour and birth subscale from the Experience of Maternity Care questionnaire was used to assess the primary outcome of care experiences. A total of 680 women completed the questionnaire approximately within two days after birth (mean 2.1 days) at a hospital in Trondheim, in central Norway. The questionnaire was provided in eight languages.

Results

The 680 respondents were classified as immigrants (n = 153) and non-immigrants (n = 527). Most women rated their quality of care during childbirth as high (91.5%). However, one-quarter of the women (26.6%) reported unmet health care needs during childbirth. Multiparous immigrant women were more likely than multiparous non-immigrant women to report that their health care needs were unmet during childbirth (OR: 3.31, 95% CI: 1.91–5.72, p < 0.001, aOR: 2.83, 95% CI: 1.53–5.18, p = 0.001). No other significant differences between immigrant versus non-immigrant women were found in subjective ratings of childbirth care experiences. Having a Norwegian-born partner and a high level of Norwegian language skills did not influence the immigrant women's experience of childbirth care.

Conclusions

Our findings indicate that many women feel they receive high-quality health care during childbirth, but a considerable number still report not having their health care needs met. Also, multiparous immigrant women report significantly more unmet health care needs than non-immigrants. Further research is required to assess immigrant women's childbirth experiences and for health care providers to give optimal care, which may need to be tailored to a woman's cultural background and individual expectations.
Comparison of infliximab with adalimumab for the treatment of non-infectious uveitis: a systematic review and meta-analysis
Authors: Liu Weishai , Bai Dan , Kou Lieling
Published: May 2023

Purpose

To compare the efficacy and safety of infliximab with that of adalimumab in the treatment of non-infectious uveitis (NIU).

Methods

We searched for relevant studies in the PubMed, Embase, ClinicalTrials.gov, Cochrane Library databases, Grey Matters, Grey Literature Report, OpenGrey, China National Knowledge Infrastructure (CNKI), and Wan Fang databases up to September 2022. The incidences of complete remission of inflammation, response to therapy, adverse events and corticosteroid-sparing effect were evaluated.

Results

Eleven clinical trials covering 1459 NIU patients were included. Complete remission of inflammation after therapy was achieved in 161 (37.5%) patients in the infliximab group and 151 (39.6%) patients in the adalimumab group. These two groups were not significantly different (P = 0.37). Four studies reported response to anti-TNF therapy involving 449 patients, of whom 241/272 (88.6%) treated with infliximab and 153/177 (86.4%) treated with adalimumab achieved partial or complete remission of inflammation. No significant difference was observed between the two cohorts in terms of response to therapy (P = 0.86). There was no significant difference between infliximab and adalimumab with regard to corticosteroid-sparing effect (P = 0.58). The pooled effect size (P = 0.001) showed a statistically significant difference, with the incidence of adverse events being 17.91% for infliximab and 12.12% for adalimumab.

Conclusion

Our systematic review and meta-analysis of 11 studies suggests that infliximab and adalimumab have similar therapeutic efficacy and corticosteroid-sparing effect in patients with NIU. However, adalimumab has a marginal advantage over infliximab in terms of adverse events. Large-scale RCTs with a longer follow-up are required to further evaluate these two anti-TNF-α agents in patients with NIU.
A systematic review and meta-analysis of the association of dietary diversity with undernutrition in school-aged children
Authors: Zeinalabedini Mobina , Zamani Behzad , Nasli-Esfahani Ensieh , Azadbakht Leila
Published: May 2023

Background

Malnutrition in childhood has lasting consequences; its effects not only last a lifetime but are also passed down from generation to generation such as short stature, school-aged children are the most vulnerable section of the population and require special attention, including nutrition.

Method

We searched Medline through PubMed, Scopus, and Web of Science to identify all observational studies published before Jun 2022. Observational studies with a pediatric population aged 5–18 years that evaluated risk estimate with 95% confidence intervals the relationship between dietary diversity and undernutrition (wasting, stunting, and thinness) were included. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) were followed.

Results

This is a first systematic review and meta-analysis with a total of 20 studies were eligible (n = 18 388). Fourteen data evaluated stunting resulting in a pooled effect size estimated odds ratio of 1.43 (95% CI: 1.08–1.89; p = 0.013). Ten data evaluated Thinness resulting in a pooled effect size estimated odds ratio of 1.10 (95% CI: 0.81–1.49; P = 0.542). Two studies were revealed wasting with a odds ratio of 2.18 (95% CI: 1.41–3.36; p-value < 0.001).

Conclusion

According to the conclusions of this meta-analysis of cross-sectional studies, inadequate dietary diversity increases the risk of undernutrition in growth linear but not in thinness in school-aged children. The findings of this analysis suggest that initiatives that support improvements to the diversity of children’s diets to reduce the risk of undernutrition may be warranted in LMICs.
Effect of sugar-sweetened beverage taxation on sugars intake and dental caries: an umbrella review of a global perspective
Authors: Hajishafiee Maryam , Kapellas Kostas , Listl Stefan , Pattamatta Madhuri , Gkekas Athanasios , Moynihan Paula
Published: May 2023

Background

As part of the Global Strategy on Oral health, the World Health Organization (WHO) is exploring cost-effective interventions for oral health, including taxation on sugar-sweetened beverages (SSBs). To inform this process, this umbrella review aimed to identify the best available estimates pertaining to the impact of SSB taxation on the reduction of sugars intake, and the sugars-caries dose–response, such that estimates of the impact of SSB taxation on averting dental caries in both high (HIC) and low and middle (LMIC) countries be available.

Methods

The questions addressed were: (1) what are the effects of SSB taxation on consumption of SSBs and (2) sugars? (3) What is the effect on caries of decreasing sugars? and (4) what is the likely impact of a 20% volumetric SSB tax on the number of active caries prevented over 10 years? Data sources included PubMed, Embase, Web of Science, Scopus, CINAHL, Dentistry and Oral Sciences Source, Cochrane Library, Joanna Briggs Institute (JBI) Systematic Review Register, and PROSPERO. The review was conducted with reference to JBI guidelines. The quality of included systematic reviews was assessed using AMSTAR to identify best evidence.

Results

From 419 systematic reviews identified for questions 1 & 2, and 103 for question 3, 48 (Questions 1 & 2) and 21 (Question 3) underwent full text screening, yielding 14 and five included reviews respectively. Best available data indicated a 10% tax would reduce SSB intake by 10.0% (95% CI: -5.0, 14.7%) in HIC and by 9% (range -6.0 to 12.0%) in LMIC, and that a 20% tax would reduce free sugars intake on average by 4.0 g/d in LMIC and 4.4 g/d in HIC. Based on best available dose response data, this could reduce the number of teeth with caries per adults (HIC and LMIC) by 0.03 and caries occurrence in children by 2.7% (LMIC) and 2.9% (HIC), over a 10-year period.

Conclusion

Best available data suggest a 20% volumetric SSB tax would have a modest impact on prevalence and severity of dental caries in both HIC and LMIC.
Determinants of province-based health service utilization according to Andersen’ s Behavioral Model: a population-based spatial panel modeling study
Authors: Xin Yu , Ren Xiaohui
Published: May 2023

Objective

The Andersen’ s Behavioral Model was used to explore the impact of various factors on the utilization of health services. The purpose of this study is to establish a provincial-level proxy framework for the utilization of health services from a spatial perspective, based on the influencing factors of the Andersen’ s Behavioral Model.

Method

Provincial-level health service utilization was estimated by the annual hospitalization rate of residents and the average number of outpatient visits per year from China Statistical Yearbook 2010–2021. Exploring the relevant influencing factors of health service utilization using the spatial panel Durbin model. Spatial spillover effects were introduced to interpret the direct and indirect effects influenced by the proxy framework for predisposing, enabling, and need factors on health services utilization.

Results

From 2010 − 2020, the resident hospitalization rate increased from 6.39% ± 1.23% to 15.57% ± 2.61%, and the average number of outpatient visits per year increased from 1.53 ± 0.86 to 5.30 ± 1.54 in China. For different provinces, the utilization of health services is uneven. The results of the Durbin model show that locally influencing factors were statistically significantly related to an increase in the resident hospitalization rate, including the proportion of 65-year-olds, GDP per capita, percentage of medical insurance participants, and health resources index, while statistically related to the average number of outpatient visits per year, including the illiteracy rate and GDP per capita. Direct and indirect effects decomposition of resident hospitalization rate associated influencing factors demonstrated that proportion of 65-year-olds, GDP per capita, percentage of medical insurance participants, and health resources index not only affected local resident hospitalization rate but also exerted spatial spillover effects toward geographical neighbors. The illiteracy rate and GDP per capita have significant local and neighbor impacts on the average number of outpatient visits.

Conclusion

Health services utilization was a variable varied by region and should be considered in a geographic context with spatial attributes. From the spatial perspective, this study identified the local and neighbor impacts of predisposing factors, enabling factors, and need factors that contributed to disparities in local health services utilization.
The PaO2/FiO2 is independently associated with 28-day mortality in patients with sepsis: a retrospective analysis from MIMIC-IV database
Authors: Bi Hongying , Liu Xu , Chen Chi , Chen Lu , Liu Xian , Zhong Jianmin , Tang Yan
Published: May 2023

Background

To clarify the relationship between the PaO2/FiO2 and 28-day mortality in patients with sepsis.

Methods

This was a retrospective cohort study regarding MIMIC-IV database. Nineteen thousand two hundred thirty-three patients with sepsis were included in the final analysis. PaO2/FiO2 was exposure variable, 28-day mortality was outcome variable. PaO2/FiO2 was log-transformed as LnPaO2/FiO2. Binary logistic regression was used to explore the independent effects of LnPaO2/FiO2 on 28-day mortality using non-adjusted and multivariate-adjusted models. A generalized additive model (GAM) and smoothed curve fitting was used to investigate the non-linear relationship between LnPaO2/FiO2 and 28-day mortality. A two-piecewise linear model was used to calculate the OR and 95% CI on either side of the inflection point.

Results

The relationship between LnPaO2/FiO2 and risk of 28-day death in sepsis patients was U-shape. The inflection point of LnPaO2/FiO2 was 5.30 (95%CI: 5.21—5.39), which indicated the inflection point of PaO2/FiO2 was 200.33 mmHg (95%CI: 183.09 mmHg—219.20 mmHg). On the left of inflection point, LnPaO2/FiO2 was negatively correlated with 28-day mortality (OR: 0.37, 95%CI: 0.32—0.43, p < 0.0001). On the right of inflection point, LnPaO2/FiO2 was positively correlated with 28-day mortality in patients with sepsis (OR: 1.53, 95%CI: 1.31—1.80, p < 0.0001).

Conclusions

In patients with sepsis, either a high or low PaO2/FiO2 was associated with an increased risk of 28-day mortality. In the range of 183.09 mmHg to 219.20 mmHg, PaO2/FiO2 was associated with a lower risk of 28-day death in patients with sepsis.
A comprehensive study on the mechanical effects of implant-supported prostheses under multi-directional loading and different occlusal contact points
Authors: Tak Sangmyeong , Jeong Yuwon , Kim Jong-Eun , Kim Jee-Hwan , Lee Hyeonjong
Published: May 2023

Aims

To evaluate screw loosening and fracture load and angular deviation of a single implant-supported prosthesis under multi-directional loading condition at three different occlusal contact points.

Methods

A total of 40 metal crowns were cemented to external connection implants and were embedded vertically and obliquely. The occlusal surface of the crown was designed with three flat surfaces, contact a, b, and c, representing outer and inner 20-degree inclination for buccal and lingual cusps. The angular deviations of implant crown under static 50N of loading were measured. And screw removal torque was evaluated before and after 57,600 load cycles. Then, fracture load was measured for each specimen. Data analysis was performed using one-way analysis of variance test of significance followed by Tukey honest significant difference (HSD) test(p < 0.05).

Results

Angular deviation results showed statistical significance between all contact points in vertically embedded group compared to obliquely embedded group, which showed similar results between contact A and B compared to C. In the other hand, screw loosening evaluation did not show statistical significance among the tested groups. And for the fracture load evaluation the maximum values reached twice the yield values in all contact areas.

Conclusions

Mechanical effects were different regarding to diverse loading direction and contact points. The results of this study suggest that the stress concentration might increase in unfavorable vector direction.
The future of CRISPR in Mycobacterium tuberculosis infection
Authors: Zein-Eddine Rima , Refrégier Guislaine , Cervantes Jorge , Yokobori Noemí Kaoru
Published: May 2023

Clustered Regularly Interspaced Short Palindromic repeats (CRISPR)-Cas systems rapidly raised from a bacterial genetic curiosity to the most popular tool for genetic modifications which revolutionized the study of microbial physiology. Due to the highly conserved nature of the CRISPR locus in Mycobacterium tuberculosis, the etiological agent of one of the deadliest infectious diseases globally, initially, little attention was paid to its CRISPR locus, other than as a phylogenetic marker. Recent research shows that M. tuberculosis has a partially functional Type III CRISPR, which provides a defense mechanism against foreign genetic elements mediated by the ancillary RNAse Csm6. With the advent of CRISPR-Cas based gene edition technologies, our possibilities to explore the biology of M. tuberculosis and its interaction with the host immune system are boosted. CRISPR-based diagnostic methods can lower the detection threshold to femtomolar levels, which could contribute to the diagnosis of the still elusive paucibacillary and extrapulmonary tuberculosis cases. In addition, one-pot and point-of-care tests are under development, and future challenges are discussed. We present in this literature review the potential and actual impact of CRISPR-Cas research on human tuberculosis understanding and management. Altogether, the CRISPR-revolution will revitalize the fight against tuberculosis with more research and technological developments.
Kidney function loss and albuminuria progression with GLP-1 receptor agonists versus basal insulin in patients with type 2 diabetes: real-world evidence
Authors: Schechter Meir , Melzer Cohen Cheli , Fishkin Alisa , Rozenberg Aliza , Yanuv Ilan , Sehtman-Shachar Dvora R. , Chodick Gabriel , Clark Alice , Abrahamsen Trine J. , Lawson Jack , Karasik Avraham , Mosenzon Ofri
Published: May 2023

Background

In clinical trials enrolling patients with type 2 diabetes (T2D) at high cardiovascular risk, many glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improved albuminuria status and possibly mitigated kidney function loss. However, limited data are available regarding the effects of GLP-1 RAs on albuminuria status and kidney function in real-world settings, including populations with a lower baseline cardiovascular and kidney risk. We assessed the association of GLP-1 RAs initiation with long-term kidney outcomes in the Maccabi Healthcare Services database, Israel.

Methods

Adults with T2D treated with  ≥ 2 glucose-lowering agents who initiated GLP-1 RAs or basal insulin from 2010 to 2019 were propensity-score matched (1:1) and followed until October 2021 (intention-to-treat [ITT]). In an as-treated (AT) analysis, follow-up was also censored at study-drug discontinuation or comparator-initiation. We assessed the risk of a composite kidney outcome, including confirmed  ≥ 40% eGFR loss or end-stage kidney disease, and the risk of new macroalbuminuria. Treatment-effect on eGFR slopes was assessed by fitting a linear regression model per patient, followed by a t-test to compare the slopes between the groups.

Results

Each propensity-score matched group constituted 3424 patients, 45% women, 21% had a history of cardiovascular disease, and 13.9% were treated with sodium-glucose cotransporter-2 inhibitors at baseline. Mean eGFR was 90.6 mL/min/1.73 m2 (SD 19.3) and median UACR was 14.6 mg/g [IQR 0.0–54.7]. Medians follow-up were 81.1 months (ITT) and 22.3 months (AT). The hazard-ratios [95% CI] of the composite kidney outcome with GLP-1 RAs versus basal insulin were 0.96 [0.82–1.11] (p = 0.566) and 0.71 [0.54–0.95] (p = 0.020) in the ITT and AT analyses, respectively. The respective HRs for first new macroalbuminuria were 0.87 [0.75–0.997] and 0.80 [0.64–0.995]. The use of GLP-1 RA was associated with a less steep eGFR slope compared with basal insulin in the AT analysis (mean annual between-group difference of 0.42 mL/min/1.73 m2/year [95%CI 0.11–0.73]; p = 0.008).

Conclusion

Initiation of GLP-1 RAs in a real-world setting is associated with a reduced risk of albuminuria progression and possible mitigation of kidney function loss in patients with T2D and mostly preserved kidney function.
Oxaliplatin related lncRNAs prognostic models predict the prognosis of patients given oxaliplatin-based chemotherapy
Authors: Zhou Qing-nan , Lei Rong-e , Liang Yun-xiao , Li Si-qi , Guo Xian-wen , Hu Bang-li
Published: May 2023

Background

Oxaliplatin-based chemotherapy is the first-line treatment for colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have been implicated in chemotherapy sensitivity. This study aimed to identify lncRNAs related to oxaliplatin sensitivity and predict the prognosis of CRC patients underwent oxaliplatin-based chemotherapy.

Methods

Data from the Genomics of Drug Sensitivity in Cancer (GDSC) was used to screen for lncRNAs related to oxaliplatin sensitivity. Four machine learning algorithms (LASSO, Decision tree, Random-forest, and support vector machine) were applied to identify the key lncRNAs. A predictive model for oxaliplatin sensitivity and a prognostic model based on key lncRNAs were established. The published datasets, and cell experiments were used to verify the predictive value.

Results

A total of 805 tumor cell lines from GDSC were divided into oxaliplatin sensitive (top 1/3) and resistant (bottom 1/3) groups based on their IC50 values, and 113 lncRNAs, which were differentially expressed between the two groups, were selected and incorporated into four machine learning algorithms, and seven key lncRNAs were identified. The predictive model exhibited good predictions for oxaliplatin sensitivity. The prognostic model exhibited high performance in patients with CRC who underwent oxaliplatin-based chemotherapies. Four lncRNAs, including C20orf197, UCA1, MIR17HG, and MIR22HG, displayed consistent responses to oxaliplatin treatment in the validation analysis.

Conclusion

Certain lncRNAs were associated with oxaliplatin sensitivity and predicted the response to oxaliplatin treatment. The prognostic models established based on the key lncRNAs could predict the prognosis of patients given oxaliplatin-based chemotherapy.