bluuebunny/crossref_metadata_2025 huggingface dataset:
Automatic video analysis and classification of sleep‐related hypermotor seizures and disorders of arousal
Authors: Moro Matteo , Pastore Vito Paolo , Marchesi Giorgia , Proserpio Paola , Tassi Laura , Castelnovo Anna , Manconi Mauro , Nobile Giulia , Cordani Ramona , Gibbs Steve A. , Odone Francesca , Casadio Maura , Nobili Lino
Published: April 2023

Objective

Sleep‐related hypermotor epilepsy (SHE) is a focal epilepsy with seizures occurring mostly during sleep. SHE seizures present different motor characteristics ranging from dystonic posturing to hyperkinetic motor patterns, sometimes associated with affective symptoms and complex behaviors. Disorders of arousal (DOA) are sleep disorders with paroxysmal episodes that may present analogies with SHE seizures. Accurate interpretation of the different SHE patterns and their differentiation from DOA manifestations can be difficult and expensive, and can require highly skilled personnel not always available. Furthermore, it is operator dependent.

Methods

Common techniques for human motion analysis, such as wearable sensors (e.g., accelerometers) and motion capture systems, have been considered to overcome these problems. Unfortunately, these systems are cumbersome and they require trained personnel for marker and sensor positioning, limiting their use in the epilepsy domain. To overcome these problems, recently significant effort has been spent in studying automatic methods based on video analysis for the characterization of human motion. Systems based on computer vision and deep learning have been exploited in many fields, but epilepsy has received limited attention.

Results

In this paper, we present a pipeline composed of a set of three‐dimensional convolutional neural networks that, starting from video recordings, reached an overall accuracy of 80% in the classification of different SHE semiology patterns and DOA.

Significance

The preliminary results obtained in this study highlight that our deep learning pipeline could be used by physicians as a tool to support them in the differential diagnosis of the different patterns of SHE and DOA, and encourage further investigation.
The seasonality of new‐onset refractory status epilepticus (NORSE)
Authors: Gopaul Margaret T. , Hanin Aurélie , Cespedes Jorge , Pulluru Yashwanth , Kazazian Karnig , van Baalen Andreas , Gofton Teneille E. , Gaspard Nicolas , Hirsch Lawrence J.
Published: April 2023

The etiology of new‐onset refractory status epilepticus (NORSE), including its subtype with prior fever known as FIRES (febrile infection‐related epilepsy syndrome), remains uncertain. Several arguments suggest that NORSE is a disorder of immunity, likely post‐infectious. Consequently, seasonal occurrence might be anticipated. Herein we investigated if seasonality is a notable factor regarding NORSE presentation. We combined four different data sets with a total of 342 cases, all from the northern hemisphere, and 62% adults. The incidence of NORSE cases differed between seasons (p = .0068) and was highest in the summer (32.2%) (p = .0022) and lowest in the spring (19.0%, p = .010). Although both FIRES and non‐FIRES cases occurred most commonly during the summer, there was a trend toward FIRES cases being more likely to occur in the winter than non‐FIRES cases (OR 1.62, p = .071). The seasonality of NORSE cases differed according to the etiology (p = .024). NORSE cases eventually associated with autoimmune/paraneoplastic encephalitis occurred most frequently in the summer (p = .032) and least frequently in the winter (p = .047), whereas there was no seasonality for cryptogenic cases. This study suggests that NORSE overall and NORSE related to autoimmune/paraneoplastic encephalitis are more common in the summer, but that there is no definite seasonality in cryptogenic cases.
Multilocus approach reveals distinct evolutionary units of the South American apapa Pellona flavipinnis (Valenciennes, 1837) (Clupeiformes, Pristigasteridae)
Authors: Ximenes Aline Mourão , Machado Valéria Nogueira , Hernandez‐Ruz Emil José , de Lima Muniz Fábio , Hrbek Tomas , Farias Izeni Pires
Published: April 2023

The discovery and characterization of cryptic diversity is important for conservation and management, especially for ichthyofauna, whose diversity is underestimated and understudied. Cryptic diversity is especially common in widely distributed species, and Pellona flavipinnis is one such species. Thus, the aim of the present study was to investigate and test whether P. flavipinnis harbours cryptic diversity. In this study we used the COI and control region sequences and microsatellite loci of 86–114 specimens from 11–12 locations throughout the Amazon basin, depending on the molecular marker used. We also included two COI GenBank sequences from the type locality of the species, the Paraná River. The results from COI sequences showed that P. flavipinnis from the Amazon basin presented two spatially structured lineages differentiated from P. flavipinnis from the Paraná River by 10.6%–9.8% (depending on the lineages) and 45 mutational steps. The genetic distance between the Amazon lineages was 2.4% using COI, with high population differentiation values (ФST = 0.8686 and ФST = 0.8483 for COI and control region, respectively). Among the five species delimitation methods employed, three indicated two lineages in P. flavipinnis in the Amazon basin, and all five methods indicated that the Amazonian lineages are different from that of Paraná. Results from microsatellite loci also showed that P. flavipinnis from the Amazon basin is composed of two evolutionary units. The results of 13 morphometric measurements indicated that there are no differences in shape between the P. flavipinnis lineages in the Amazon basin. The present findings suggest that there are two sympatric lineages of P. flavipinnis in the Amazon basin.
Geographical indications and traditional cultural expressions: A comparative legal analysis of the GI laws of Indonesia and India and a case study analysis
Authors: K. P. Sreenath , C. J. Anson
Published: April 2023

Many of the geographical indications (GI) in developing countries are intellectual creations with incredible uniqueness generated by traditional communities and local people. These products are linked to the culture of that community and hence can be considered as traditional cultural expressions (TCE). Dev gangjee and Steven Van Uytsel and argued that TCE can be protected under the law of GI. Moreover, there are many similarities between GI and TCEs. These two forms share some unique characteristics that other intellectual property systems are not indulged in as well as not in concern with of many nations. Handicrafts, textile products, pottery works, jewellery works are some prime examples of TCEs protected under the law of GI in India and Indonesia. This article intends to validate the compatibility of GI laws in providing space for TCEs and give some suggestions for enhanced compatibility. Case study approach has been used as methodology and that the study presumes that the present GI laws in India and Indonesia are not capable of adequately protecting TCE.
Spiritual Experience: Its Scope, Its Phenomenology, and Its Source
Authors: Cottingham John
Published: April 2023

This paper looks first at the scope of religious experience, offering some representative examples of phenomena that typically give rise to spiritual experiences. This leads on a consideration of the phenomenology of such experiences – the particular way in which they present themselves to the conscious subject. Lastly, the paper tackles the vexed question of the source of such experiences, and suggests that this is best understood in terms of a (certain kind of) theistic framework.
Early Life Exposure to Above Average Rainfall and Adult Mental Health*
Authors: Pasha Mochamad , Rockmore Marc , Tan Chih Ming , Thamarapani Dhanushka
Published: April 2023

We study the effects of early life exposure to above average levels of rainfall on adult mental health. While we find no effect from prenatal exposure, postnatal positive rainfall shocks decrease average Center for Epidemiological Studies Depression (CESD) mental health scores by 13% and increase the likelihood of depression by 6%, a more than 26% increase relative to the mean. These effects are limited to females. We rule out prenatal stress and income shocks as pathways. Early life exposure to infectious diseases appears to play a limited role but further research is required.
Earnings, Cohort Effects, and Inter‐Generational Inequality: Evidence From the Luxembourg Income Study
Authors: Freedman Michael
Published: April 2023

Research suggests that inequalities between generations are most pronounced in the conservative European welfare states. However, it is likely that across all advanced capitalist societies superior earnings opportunities and steady employment are pursued at a later age due to secular labor market trends. In this paper, I examine the variation in generational inequalities across different regimes using data from the Luxembourg Income Study (LIS). The repeated cross‐sectional data allow me to trace the generational changes in income for eight countries, using both Age Period Cohort (APC) and synthetic cohort models. My results suggest that for most countries, cohorts born after 1980 have experienced lower entry‐level earning opportunities, relative to cohorts born between 1960 and 1980. However, synthetic cohort models suggest that while recent generations have suffered from successively worse entry positions, they appear to be “catching up,” which suggests that permanent “scarring effects” to lifetime earnings may not be inevitable.
Genetic diversity of the threatened Saussurea dorogostaiskii (Asteraceae) in the Khuvsgul region of Mongolia
Authors: NYAMGEREL Nudkhuu , BAASANMUNKH Shukherdorj , OYUNTSETSEG Batlai , OYUNTSETSEG Dashzeveg , NORRIS Joscelyn , CHOI Hyeok Jae , BAYARMAA Gun-Aajav
Published: April 2023

Saussurea dorogostaiskii Palib. (Asteraceae) is a critically endangered medicinal plant in Mongolia and Russia. We studied the genetic variation of S. dorogostaiskii from three mountains of northern Mongolia. The genetic profile was assessed in 70 individuals from eight populations using five inter-simple sequence repeat markers, producing 53 loci with 96.4% polymorphism across all bands. Shannon’s index (I) and Nei’s gene diversity (H) value at the species level of S. dorogostaiskii are 0.25 and 0.17, respectively. An AMOVA showed high genetic variation among the populations (22% of populations and 32% of mountains), consistent with the high genetic differentiation (GST = 0.49) and low gene flow (Nm = 0.51) in S. dorogostaiskii populations. Eight populations were clustered into two groups, corresponding to their geographic locations. The low within-population genetic diversity and high genetic differentiation among S. dorogostaiskii populations factor into their endangered designation. This genetic analysis reveals that all populations are equally threatened, and community-based conservation is appropriate for these species.
Gaudin algebras, RSK and Calogero–Moser cells in Type A
Authors: Brochier Adrien , Gordon Iain , White Noah
Published: April 2023

We study the spectrum of a family of algebras, the inhomogeneous Gaudin algebras, acting on the ‐fold tensor representation of the Lie algebra . We use the work of Halacheva–Kamnitzer–Rybnikov–Weekes to demonstrate that the Robinson–Schensted–Knuth correspondence describes the behaviour of the spectrum as we move along special paths in the family. We apply the work of Mukhin–Tarasov–Varchenko, which proves that the rational Calogero–Moser phase space can be realised as a part of this spectrum, to relate this to behaviour at of rational Cherednik algebras of . As a result, we confirm for symmetric groups a conjecture of Bonnafé–Rouquier which proposes an equality between the Calogero–Moser cells they defined and the well‐known Kazhdan–Lusztig cells.
Diversity of
Monochaetia
Species from Fagaceous Leaf Spots in China and Pathogenicity for Chinese Chestnut
Authors: Jiang Ning , Voglmayr Hermann , Xue Han , Piao Chun-Gen , Li Yong
Published: April 2023

Monochaetia
is a pestalotioid genus, with members that are commonly known as leaf pathogens or saprobes; some strains were isolated from air, in which case their natural substrate is so far unknown.
Fagaceae
represents an ecologically and economically important plant family that is widely distributed in the Northern Hemisphere, including an important tree crop species,
Castanea mollissima
, which is widely cultivated in China. In the present study, diseased leaves of
Fagaceae
in China were investigated, and five new
Monochaetia
species were introduced based on morphology and phylogeny of combined ITS, LSU,
tef1
, and
tub2
loci.
Bif-1c Attenuates Viral Proliferation by Regulating Autophagic Flux Blockade Induced by the Rabies Virus CVS-11 Strain in N2a Cells
Authors: Hou Pengfei , Guo Yidi , Jin Hongli , Sun Jingxuan , Bai Yujie , Li Wujian , Li Ling , Cao Zengguo , Wu Fangfang , Zhang Haili , Li Yuanyuan , Yang Songtao , Xia Xianzhu , Huang Pei , Wang Hualei
Published: April 2023

Autophagy can be triggered by viral infection and replication. Autophagosomes are generated and affect RABV replication, which differs by viral strain and infected cell type.
Supplemental Material: Physicochemical evolution and mechanism of a skarn system: Insights from the world-class Mazraeh Cu deposit, NW Iran
Authors: Rajabpour Shahrokh , al. et
Published: April 2023

Table S1: Representative EPMA analyses (in wt%) of garnet and the molecular proportions of its end-members. Table S2: Representative EPMA analyses (in wt%) of pyroxene and the molecular proportions of its end-members. Table S3: Bulk-rock major and trace elements composition of selected granodiorite samples. Table S4: Types of fluid inclusions in minerals from various hydrothermal assemblages of the Mazraeh deposit and their microthermometry results for 49 FIAs. Table S5: Oxygen, hydrogen and sulfur isotope compositions of different minerals and their calculated equilibrium fluids. 
Calcific uraemic arteriolopathy presenting as cellulitis of the dorsal foot
Authors: Ficenec Samuel , Gerstein Brittany , Shamburger Christopher Dale
Published: April 2023

Calcific uraemic arteriolopathy (CUA) is a rare and poorly understood entity that typically presents with painful lesions affecting adipose-rich areas of the lower extremities. We report an unusual case of CUA presenting as presumed cellulitis of the dorsal surface of the distal lower extremity with acute development of a bullous lesion. As CUA incidence is predicted to increase due to its relationship with end-stage renal disease, recognising the full clinical spectrum of this disease is essential to promote further understanding of this disorder and exploration of additional therapeutics to limit disease morbidity and mortality.
Postoperative necrotising enterocolitis following incarcerated inguinal hernia repair
Authors: Prasad Gaurav , Dalai Richie , Dhua Anjan Kumar , Anand Sachit
Published: April 2023

The occurrence of postoperative necrotising enterocolitis (NEC) is rare. In comparison with the commonly known inciting factors for the development of NEC, surgical stress as a cause of NEC is relatively uncommon. We report a case of incarcerated inguinal hernia in a preterm infant who clinically deteriorated in the postoperative period because of NEC following herniotomy. The patient’s clinical, biochemical and radiological features were suggestive of NEC, and the patient responded to the appropriate treatment based on the diagnosis. To conclude, incarcerated inguinal hernia should always be considered a causative factor for postoperative NEC.
Rate pressure product as a novel predictor of long-term adverse outcomes in patients after percutaneous coronary intervention: a retrospective cohort study
Authors: Jiang Zhi-Hui , Aierken Abudula , Wu Ting-Ting , Zheng Ying-Ying , Ma Yi-Tong , Xie Xiang
Published: April 2023

Objectives

Previous studies have suggested that heart rate and blood pressure play important roles in the development of adverse outcomes in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI). However, the relationship between the rate pressure product (RPP) and long-term outcomes has rarely been investigated. This study investigated the effects of RPP on the clinical outcomes of patients with CAD who underwent PCI.

Design

In this study, a total of 6015 patients with CAD were enrolled. All patients were from the CORFCHD-PCI (Clinical Outcomes and Risk Factors of Patients with Coronary Heart Disease after PCI) Study. They were divided into two groups according to RPP (RPP <10 269, n=4018 and RPP ≥10 269, n=1997). In addition, the median follow-up time was 32 months.

Participants

Data was obtained from 6050 patients with CAD who underwent PCI at the First Affiliated Hospital of Xinjiang Medical University from January 2008 to December 2016.

Primary and secondary outcome measures

The primary endpoint was long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints were major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs).

Results

We found that there were significant differences between the two groups in the incidence of ACM, CM, MACCEs and MACEs (all p<0.05). Among the patients with CAD having ACM, CM, MACCEs and MACEs, the mean survival time of the low-value group was significantly higher than that of the high-value group. Multivariate Cox regression analyses showed that RPP was an independent predictor for ACM (HR=1.605, 95% CI: 1.215–2.120, p=0.001), CM (HR=1.733, 95% CI: 1.267–2.369, p=0.001), MACCEs (HR=1.271, 95% CI: 1.063–1.518, p=0.008) and MACEs (HR=1.315, 95% CI: 1.092–1.584, p=0.004) in patients with stable CAD. On the other hand, there was no significant correlation between the RPP and the adverse outcomes in patients with acute coronary syndrome.

Conclusion

In summary, RPP is an independent predictor of long-term prognosis in patients with CAD who underwent PCI. A higher baseline RPP before PCI increased the risk of adverse outcomes. Compared with heart rate and blood pressure alone, RPP has a higher predictive value for adverse clinical outcomes.
Structural and Mechanical Behavior of Copper-TiC-Graphite Hybrid Metal Matrix Composites Fabricated by Microwave Sintering Technique
Authors: Kumar Vimal , Yadav Gaurav , Gupta Pallav
Published: April 2023

For electrical sliding contact applications, there are important criteria such as superior tribological qualities in addition to strong electrical conductivity. This calls for the development of advanced metal matrix composites based on copper. Although adding graphite to a copper matrix results in a self-lubricating feature, the composite’s strength declines. Harder ceramic particles like SiC, TiC, and Al2O3 may be used to reinforce the composite to increase its strength. This study looked at the construction of a hybrid composite made of a copper metal matrix reinforced with TiC and graphite particles. The impact of TiC (5, 10, and 15 vol.%) and graphite (5 and 10 vol.%) reinforcements on the structural, physical and mechanical characteristics of copper-TiC-graphite hybrid composites that were microwave-sintered are thoroughly explored. The consistent distribution of reinforcements in the copper matrix is seen in micrographs. In comparison to traditionally sintered composites, microwave-sintered ones showed greater relative density, sintered density, and hardness.
Novel Soliton Solutions for the (3 + 1)-Dimensional Sakovich Equation Using Different Analytical Methods
Authors: Ali Khalid K. , AlQahtani Salman A. , Mehanna M. S. , Wazwaz Abdul-Majid
Published: April 2023

In the work that we are doing now, our goal is to find a solution to the (3 + 1)-dimensional Sakovich equation, which is an equation that can be used to characterize the movement of nonlinear waves. This approach sees extensive use across the board in engineering’s many subfields. This new equation can represent more dispersion and nonlinear effects, which allows it to accept more different application scenarios. As a result, it has a wider range of potential applications in the physical world. As a consequence of this, when the two components are combined, they can be used to easily counteract the effects of nonlinearity and dispersion on the integrability of partially differential equations. This equation represents a novel physical paradigm that should be looked into further. We use the following three analytical techniques: the

exp

−
ψ

η

expansion method is the first one, the second is the

G

′

/

k

G

′

+
G
+
r

expansion method, and the Bernoulli sub-ODE technique is the last one. Lastly, the soliton solutions obtained are presented by graphs in two and three dimensions, which present different kinds of solitons such as dark, periodic, exponential, bright, and singular soliton solutions.
Evaluation of a High-Accuracy Indoor-Positioning System with Wi-Fi Time of Flight (ToF) and Deep Learning
Authors: Perdana Doan , Indra Tanaya I Made Arya , Marwan Abdul Aziz , Akhyar Fityanul
Published: April 2023

This article proposes the use of Wi-Fi ToF and a deep learning approach to build a cheap, practical, and highly-accurate IPS. To complement that, rather than using the classic geometrical approach (such as multilateration), it uses a more data-driven approach, i.e., the location fingerprinting technique. The fingerprint of a location, in this case, is a set of Wi-Fi ToFs between the target device and an access point (AP). Therefore, the number of APs in the area dictates the set size. The location fingerprinting technique requires a collection of fingerprints of various locations in the area to build a reference database or map. This database or map contains the information used to carry out the main task of the location fingerprinting technique, namely, estimating the position of a device based on its location fingerprint. For that task, we propose using a fully connected deep neural network (FCDNN) model to act as a positioning engine. The model is given a location fingerprint as its input to produce the estimated location coordinates as its output. We conduct an experiment to analyze the impact of the available AP pair in the dataset, from 1 unique AP pair, 2 AP pairs, and more, using WKNN and FCDNN to compare their performance. Our experimental results show that our IPS, DeepIndoor, can achieve an average positioning error or mean square error of 0.1749 m, and root mean square error of 0.5740 m in scenario 3, where 1–10 AP pairs or the raw dataset is used.
Hybrid Techniques for Diagnosing Endoscopy Images for Early Detection of Gastrointestinal Disease Based on Fusion Features
Authors: Ghaleb Al-Mekhlafi Zeyad , Mohammed Senan Ebrahim , Sulaiman Alshudukhi Jalawi , Abdulkarem Mohammed Badiea
Published: April 2023

Gastrointestinal (GI) diseases, particularly tumours, are considered one of the most widespread and dangerous diseases and thus need timely health care for early detection to reduce deaths. Endoscopy technology is an effective technique for diagnosing GI diseases, thus producing a video containing thousands of frames. However, it is difficult to analyse all the images by a gastroenterologist, and it takes a long time to keep track of all the frames. Thus, artificial intelligence systems provide solutions to this challenge by analysing thousands of images with high speed and effective accuracy. Hence, systems with different methodologies are developed in this work. The first methodology for diagnosing endoscopy images of GI diseases is by using VGG‐16 + SVM and DenseNet‐121 + SVM. The second methodology for diagnosing endoscopy images of gastrointestinal diseases by artificial neural network (ANN) is based on fused features between VGG‐16 and DenseNet‐121 before and after high‐dimensionality reduction by the principal component analysis (PCA). The third methodology is by ANN and is based on the fused features between VGG‐16 and handcrafted features and features fused between DenseNet‐121 and the handcrafted features. Herein, handcrafted features combine the features of gray level cooccurrence matrix (GLCM), discrete wavelet transform (DWT), fuzzy colour histogram (FCH), and local binary pattern (LBP) methods. All systems achieved promising results for diagnosing endoscopy images of the gastroenterology data set. The ANN network reached an accuracy, sensitivity, precision, specificity, and an AUC of 98.9%, 98.70%, 98.94%, 99.69%, and 99.51%, respectively, based on fused features of the VGG‐16 and the handcrafted.
Supplementary Table S2 from Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer
Authors: Bellido Molias Fernando , Sim Andre , Leong Ka Wai , An Omer , Song Yangyang , Ng Vanessa Hui En , Lim Max Wei Jie , Ying Chen , Teo Jasmin Xin Jia , Göke Jonathan , Chen Leilei
Published: April 2023

List of ncNATs expressed in TCGA tumors, for which their associated sense genes have two active alternative promoters
Supplementary Table S1 from Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer
Authors: Bellido Molias Fernando , Sim Andre , Leong Ka Wai , An Omer , Song Yangyang , Ng Vanessa Hui En , Lim Max Wei Jie , Ying Chen , Teo Jasmin Xin Jia , Göke Jonathan , Chen Leilei
Published: April 2023

Exhaustive list of sense-gene promoters considered in our analysis.
Supplementary Data from FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1
Authors: Kwon Mijung , Rubio Genesaret , Nolan Nicholas , Auteri Peter , Volmar Jean Arly , Adem Asha , Javidian Parisa , Zhou Zhongren , Verzi Michael P. , Pine Sharon R. , Libutti Steven K.
Published: April 2023

8 Supplementary figures and 1 Supplementary info.
Supplementary Dataset 2 from SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
Authors: Chambers Courtney , Cermakova Katerina , Chan Yuen San , Kurtz Kristen , Wohlan Katharina , Lewis Andrew Henry , Wang Christiana , Pham Anh , Dejmek Milan , Sala Michal , Loeza Cabrera Mario , Aguilar Rogelio , Nencka Radim , Lacorazza H. Daniel , Rau Rachel E. , Hodges H. Courtney
Published: April 2023

Gene set enrichment analyses
Table ST9 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

Metabolomics
Table ST8 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

Table ST8: Data output of the CCLE cell line screening provided by Prof. Schreiber at Broad Institute.
Table ST2 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

Table ST2: Summary of the clinical data corresponding to the primary cell cultures used in this publication
Suppl. Figure S14 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S14: CCLE cancer cell panel analysis for the responses to neocuproine
Suppl. Figure S1 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S1: Evaluation of HST screening.
Supplementary Figures from CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
Authors: Faraoni Erika Y. , Singh Kanchan , Chandra Vidhi , Le Roux Olivereen , Dai Yulin , Sahin Ismet , O'Brien Baylee J. , Strickland Lincoln N. , Li Le , Vucic Emily , Warner Amanda N. , Pruski Melissa , Clark Trent , Van Buren George , Thosani Nirav C. , Bynon John S. , Wray Curtis J. , Bar-Sagi Dafna , Poulsen Kyle L. , Vornik Lana A. , Savage Michelle I. , Sei Shizuko , Mohammed Altaf , Zhao Zhongming , Brown Powel H. , Mills Tingting , Eltzschig Holger K. , McAllister Florencia , Bailey-Lundberg Jennifer M.
Published: April 2023

Supplementary Figures S1-9
S5 Legend from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Supplemental Figure 5 Legend
S1 from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Supplemental Figure 1
Supplementary Table2 from USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
Authors: Ren Yidan , Feng Maoxiao , Hao Xiaodong , Liu Xiaoyan , Li Juan , Li Peilong , Gao Jie , Qi Qiuchen , Du Lutao , Wang Chuanxin , Wang Qin , Wang Yunshan
Published: April 2023

Supplementary Table2
supplementary table from Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer
Authors: Malier Marie , Gharzeddine Khaldoun , Laverriere Marie-Hélène , Marsili Sabrina , Thomas Fabienne , Court Magali , Decaens Thomas , Roth Gael , Millet Arnaud
Published: April 2023

supplementary Table
Data from Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer
Authors: Evans Kurt W. , Yuca Erkan , Scott Stephen S. , Zhao Ming , Paez Arango Natalia , Cruz Pico Christian X. , Saridogan Turcin , Shariati Maryam , Class Caleb A. , Bristow Christopher A. , Vellano Christopher P. , Zheng Xiaofeng , Gonzalez-Angulo Ana Maria , Su Xiaoping , Tapia Coya , Chen Ken , Akcakanat Argun , Lim Bora , Tripathy Debu , Yap Timothy A. , Francesco Maria Emilia Di , Draetta Giulio F. , Jones Philip , Heffernan Timothy P. , Marszalek Joseph R. , Meric-Bernstam Funda
Published: April 2023

Abstract
Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who received neoadjuvant chemotherapy demonstrated that the top canonical pathway associated with worse outcome was higher expression of OXPHOS signature. IACS-10759, a novel inhibitor of OXPHOS, stabilized growth in multiple TNBC patient-derived xenografts (PDX). On gene expression profiling, all of the sensitive models displayed a basal-like 1 TNBC subtype. Expression of mitochondrial genes was significantly higher in sensitive PDXs. An in vivo functional genomics screen to identify synthetic lethal targets in tumors treated with IACS-10759 found several potential targets, including CDK4. We validated the antitumor efficacy of the combination of palbociclib, a CDK4/6 inhibitor, and IACS-10759 in vitro and in vivo. In addition, the combination of IACS-10759 and multikinase inhibitor cabozantinib had improved antitumor efficacy. Taken together, our data suggest that OXPHOS is a metabolic vulnerability in TNBC that may be leveraged with novel therapeutics in combination regimens.
Significance:
These findings suggest that triple-negative breast cancer is highly reliant on OXPHOS and that inhibiting OXPHOS may be a novel approach to enhance efficacy of several targeted therapies.
Supplementary Table S3 from Durvalumab plus Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: An Open-label, Nonrandomized, Phase II Clinical Trial
Authors: Gulati Shuchi , Crist McKenzie , Riaz Muhammed Kashif , Takiar Vinita , Lehn Maria , Monroe Ilaina , Palackdharry Sarah , Kurtzweil Nicky , Jandarov Roman , Harun Nusrat , Wise-Draper Trisha M.
Published: April 2023

Representativeness of Study Participants
Supplementary Protocol S1 from Durvalumab plus Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: An Open-label, Nonrandomized, Phase II Clinical Trial
Authors: Gulati Shuchi , Crist McKenzie , Riaz Muhammed Kashif , Takiar Vinita , Lehn Maria , Monroe Ilaina , Palackdharry Sarah , Kurtzweil Nicky , Jandarov Roman , Harun Nusrat , Wise-Draper Trisha M.
Published: April 2023

Study protocol
Figure S1 from The Oncolytic Adenovirus XVir-N-31 Joins Forces with CDK4/6 Inhibition Augmenting Innate and Adaptive Antitumor Immunity in Ewing Sarcoma
Authors: Schober Sebastian Johannes , Schoening Caroline , Eck Jennifer , Middendorf Charlotte , Lutsch Julia , Knoch Pia , von Ofen Anna Josefine , Gassmann Hendrik , Thiede Melanie , Hauer Julia , Kolk Andreas , Mantwill Klaus , Gschwend Jürgen E. , Burdach Stefan E.G. , Nawroth Roman , Thiel Uwe , Holm Per Sonne
Published: April 2023

Supplemental Figure 1: Combination of XVir-N-31 and CDK4/6 inhibition increases oncolysis, viral particle formation associated by RB downregulation.
Figure S2 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
Authors: Cole Alexander J. , Panesso-Gómez Santiago , Shah Jaynish S. , Ebai Tonge , Jiang Qi , Gumusoglu-Acar Ece , Bello Maya G. , Vlad Anda , Modugno Francesmary , Edwards Robert P. , Buckanovich Ronald J.
Published: April 2023

Supplementary Figure 2. RNA-seq analysis. A. Schematic of the RNA-seq experimental design. B. Waterfall plot of RNA-seq data showing the 141 genes which were DE at all time points compared to luciferase control in HEY1 and SKOV3 cell lines. C. Unsupervised clustering analysis of the 141 DE genes. D. Box plots demonstrating MYC expression following NFATC4 activation. E. STRING analysis of the 141 DE genes.
Data from Randomized Phase II Cabazitaxel Dose Individualization and Neutropenia Prevention Trial in Patients with Metastatic Castration-Resistant Prostate Cancer
Authors: Omlin Aurelius , Cathomas Richard , von Amsberg Gunhild , Reuter Christoph , Feyerabend Susan , Loidl Wolfgang , Boegemann Martin , Lorch Anja , Heidenreich Axel , Tsaur Igor , Larcher-Senn Julian , Buck Stefan A.J. , Mathijssen Ron H.J. , Jaehde Ulrich , Gillessen Silke , Joerger Markus
Published: April 2023

AbstractPurpose:
There is ongoing controversy about the recommended dose of cabazitaxel in patients with metastatic castration-resistant prostate cancer (mCRPC).
Experimental Design:
This multicenter phase II open-label, randomized, parallel-group study compared 3-weekly cabazitaxel at 25 mg/m2 (conventional arm A) with cabazitaxel therapeutic drug monitoring (experimental arm B) in mCRPC. The primary objective was to improve the clinical feasibility rate (CFR), defined as the absence of grade 4 neutropenia or thrombocytopenia, any thrombocytopenia with bleeding, febrile neutropenia, severe nonhematologic toxicity, withdrawal for cabazitaxel-related toxicity, or death. A total of 60 patients had to be randomized to detect a difference in CFR of 35% (power 80%, two-sided alpha 10%).
Results:
A total of 40 patients were randomized to arm A and 33 patients to arm B. CFR was 69.4% in arm A and 64.3% in arm B (P = 0.79). Week-12 PSA response was 38.5% in both arms. A radiological response by RECIST v.1.1 was seen in 3 (9.7%) patients in arm A versus 6 (23.1%) patients in arm B (P = 0.28), disease progression was higher in arm A compared with arm B (61.3% vs. 30.8%, P = 0.05). Median progression-free survival was longer in arm B compared with arm A (9.5 vs. 4.4 months; HR = 0.46; P = 0.005). Median overall survival was higher in arm B compared with arm A (16.2 vs. 7.3 months; HR = 0.33; P < 0.0001).
Conclusions:
Pharmacokinetic-guided dosing of cabazitaxel in patients with mCRPC is feasible and improves clinical outcome due to individual dose escalations in 55% of patients.
Supplementary Figure 1 from Interpreting Mammalian Target of Rapamycin and Cell Growth Inhibition in a Genetically Engineered Mouse Model of Nf1-Deficient Astrocytes
Authors: Banerjee Sutapa , Gianino Scott M. , Gao Feng , Christians Uwe , Gutmann David H.
Published: April 2023

Supplementary Figure 1 from Interpreting Mammalian Target of Rapamycin and Cell Growth Inhibition in a Genetically Engineered Mouse Model of Nf1-Deficient Astrocytes
Supplementary Figure 2 from Combining PARP-1 Inhibition and Radiation in Ewing Sarcoma Results in Lethal DNA Damage
Authors: Lee Hae-June , Yoon Changhwan , Schmidt Benjamin , Park Do Joong , Zhang Alexia Y. , Erkizan Hayriye V. , Toretsky Jeffrey A. , Kirsch David G. , Yoon Sam S.
Published: April 2023

PDF - 43KB, Quantification of cleaved caspase 3 Western blot seen in Fig. 4A
Supplementary Figure 1 from HDAC Inhibitor Entinostat Restores Responsiveness of Letrozole-Resistant MCF-7Ca Xenografts to Aromatase Inhibitors through Modulation of Her-2
Authors: Sabnis Gauri J. , Goloubeva Olga G. , Kazi Armina A. , Shah Preeti , Brodie Angela H.
Published: April 2023

PDF file - 261K, Supplemental Figure 1: Flow-cytometry analysis of LTLT-Ca cells treated with entinostat in presence of MG-132, NH4Cl or the combination of MG-132 and NH4Cl.
Data Supplement from NEO212, Temozolomide Conjugated to Perillyl Alcohol, Is a Novel Drug for Effective Treatment of a Broad Range of Temozolomide-Resistant Gliomas
Authors: Cho Hee-Yeon , Wang Weijun , Jhaveri Niyati , Lee David Jungpa , Sharma Natasha , Dubeau Louis , Schönthal Axel H. , Hofman Florence M. , Chen Thomas C.
Published: April 2023

Supplementary Figure 1. Chemical structure of NEO212.
Supplementary Figure Legend, Table 1 from Vinblastine Rapidly Induces NOXA and Acutely Sensitizes Primary Chronic Lymphocytic Leukemia Cells to ABT-737
Authors: Bates Darcy J.P. , Danilov Alexey V. , Lowrey Christopher H. , Eastman Alan
Published: April 2023

PDF file - 109K, Table S1. CLL Patient Demographics and Clinical Characteristics (n=35).
Supplementary Table 2 from Coleusin Factor, a Novel Anticancer Diterpenoid, Inhibits Osteosarcoma Growth by Inducing Bone Morphogenetic Protein-2–Dependent Differentiation
Authors: Geng Shuo , Sun Bo , Lu Ran , Wang Jingze
Published: April 2023

PDF - 60K, Primers used for real-time RT-PCR.
Supplementary Table 1 from Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo
Authors: Beider Katia , Darash-Yahana Merav , Blaier Orly , Koren-Michowitz Maya , Abraham Michal , Wald Hanna , Wald Ori , Galun Eithan , Eizenberg Orly , Peled Amnon , Nagler Arnon
Published: April 2023

PDF - 43K, Primer sequences.
Supplementary Figure 6 from CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma
Authors: Salas Fragomeni Roberto A. , Chung Hye Won , Landesman Yosef , Senapedis William , Saint-Martin Jean-Richard , Tsao Hensin , Flaherty Keith T. , Shacham Sharon , Kauffman Michael , Cusack James C.
Published: April 2023

Supplementary Figure 6 - PDF file 57K, CRM1/BRAF inhibition in PTEN null/BRAF mutant melanoma Xenograft model
Supplementary Figure 4 from Triptolide Induces the Expression of miR-142-3p: A Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation
Authors: MacKenzie Tiffany N. , Mujumdar Nameeta , Banerjee Sulagna , Sangwan Veena , Sarver Aaron , Vickers Selwyn , Subramanian Subbaya , Saluja Ashok K.
Published: April 2023

Supplementary Figure 4 - PDF file 31K, Effect of microRNA-142-3p mimic overexpression on HSPA1A (HSP70) levels
Supplementary Figure 3 from Triptolide Induces the Expression of miR-142-3p: A Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation
Authors: MacKenzie Tiffany N. , Mujumdar Nameeta , Banerjee Sulagna , Sangwan Veena , Sarver Aaron , Vickers Selwyn , Subramanian Subbaya , Saluja Ashok K.
Published: April 2023

Supplementary Figure 3 - PDF file 49K, Effect of triptolide on miRNAs known to play a role in PDAC
Supplementary Figure 2 from Regulation of SRC Kinases by microRNA-3607 Located in a Frequently Deleted Locus in Prostate Cancer
Authors: Saini Sharanjot , Majid Shahana , Shahryari Varahram , Tabatabai Z. Laura , Arora Sumit , Yamamura Soichiro , Tanaka Yuichiro , Dahiya Rajvir , Deng Guoren
Published: April 2023

PDF - 76K, Relative miR-3607 expression levels in normal immortalized prostate epithelial cell lines and prostate cancer cell lines as assessed by quantitative RT-PCR analysis.
Supplementary Movie 3 from Tivantinib (ARQ 197) Exhibits Antitumor Activity by Directly Interacting with Tubulin and Overcomes ABC Transporter–Mediated Drug Resistance
Authors: Aoyama Aki , Katayama Ryohei , Oh-hara Tomoko , Sato Shigeo , Okuno Yasushi , Fujita Naoya
Published: April 2023

Crizotinib treated (EBC-1 Fucci).
Supplementary Movie 2 from Tivantinib (ARQ 197) Exhibits Antitumor Activity by Directly Interacting with Tubulin and Overcomes ABC Transporter–Mediated Drug Resistance
Authors: Aoyama Aki , Katayama Ryohei , Oh-hara Tomoko , Sato Shigeo , Okuno Yasushi , Fujita Naoya
Published: April 2023

Tivantinib treated (EBC1-Fucci).
Supplementary Figure 7 from Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases
Authors: Kai Kazuharu , Kondo Kimie , Wang Xiaoping , Xie Xuemei , Pitner Mary K. , Reyes Monica E. , Torres-Adorno Angie M. , Masuda Hiroko , Hortobagyi Gabriel N. , Bartholomeusz Chandra , Saya Hideyuki , Tripathy Debu , Sen Subrata , Ueno Naoto T.
Published: April 2023

SA-beta-gal assay with KW-2450 in TNBC cells.
Supplementary Figure 6 from Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases
Authors: Kai Kazuharu , Kondo Kimie , Wang Xiaoping , Xie Xuemei , Pitner Mary K. , Reyes Monica E. , Torres-Adorno Angie M. , Masuda Hiroko , Hortobagyi Gabriel N. , Bartholomeusz Chandra , Saya Hideyuki , Tripathy Debu , Sen Subrata , Ueno Naoto T.
Published: April 2023

Cell cycle profile in p53-wild breast cancer cells treated with KW-2450.
Supplementary Table 1 from Akt-Activated Endothelium Constitutes the Niche for Residual Disease and Resistance to Bevacizumab in Ovarian Cancer
Authors: Guerrouahen Bella S. , Pasquier Jennifer , Kaoud Nadine Abu , Maleki Mahtab , Beauchamp Marie-Claude , Yasmeen Amber , Ghiabi Pegah , Lis Raphael , Vidal Fabien , Saleh Ahmed , Gotlieb Walter H. , Rafii Shahin , Rafii Arash
Published: April 2023

List of primers used for real time-PCR in this study
Supplementary Figure 1 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Authors: Swers Jeffery S. , Grinberg Luba , Wang Lin , Feng Hui , Lekstrom Kristen , Carrasco Rosa , Xiao Zhan , Inigo Ivan , Leow Ching Ching , Wu Herren , Tice David A. , Baca Manuel
Published: April 2023

PDF file - 63K, Identification of BRAFV600E splice variant lacking exons 2-10 in dabrafenib resistant WMD009 tumour and derived cell line.
Supplementary Figure S1 from S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab
Authors: Burbridge Mike F. , Bossard Céline J. , Saunier Carine , Fejes Imre , Bruno Alain , Léonce Stéphane , Ferry Gilles , Da Violante Georges , Bouzom François , Cattan Valérie , Jacquet-Bescond Anne , Comoglio Paolo M. , Lockhart Brian P. , Boutin Jean A. , Cordi Alex , Ortuno Jean-Claude , Pierré Alain , Hickman John A. , Cruzalegui Francisco H. , Depil Stéphane
Published: April 2023

Western blot detection of total and phosphorylated MET, AXL, FGFR1/2/3 and phosphorylated FRS2 in cell lines and tumor xenografts used in the study
Supplementary Figure 3 from Tirapazamine Sensitizes Hepatocellular Carcinoma Cells to Topoisomerase I Inhibitors via Cooperative Modulation of Hypoxia-Inducible Factor-1α
Authors: Cai Tian-Yu , Liu Xiao-Wen , Zhu Hong , Cao Ji , Zhang Jun , Ding Ling , Lou Jian-Shu , He Qiao-Jun , Yang Bo
Published: April 2023

PDF file - 293K, Figure S3. TPZ enhanced the cytotoxicity elicited by topoisomerase I inhibitors under hypoxia.
Supplementary Methods, Table S1 S2, and Figure Legends from Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments
Authors: Loganzo Frank , Tan Xingzhi , Sung Matthew , Jin Guixian , Myers Jeremy S. , Melamud Eugene , Wang Fang , Diesl Veronica , Follettie Maximillian T. , Musto Sylvia , Lam My-Hanh , Hu William , Charati Manoj B. , Khandke Kiran , Kim Kenny Sung Kyoo , Cinque Mike , Lucas Judy , Graziani Edmund , Maderna Andreas , O'Donnell Christopher J. , Arndt Kim T. , Gerber Hans-Peter
Published: April 2023

Supplementary Methods, Table S1 S2, and Figure Legends. Supplementary Table S1: Properties of cell lines made resistant to TM-conjugate. Supplementary Table S2: Relative resistance of selected free payloads and Cys-capped-released species in H69 (no ABCC1) and H69AR (high ABCC1 expressing) cell lines.
Supplementary Figure 2 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer
Authors: Kung Pei-Pei , Martinez Ricardo , Zhu Zhou , Zager Michael , Blasina Alessandra , Rymer Isha , Hallin Jill , Xu Meirong , Carroll Christopher , Chionis John , Wells Peter , Kozminski Kirk , Fan Jeffery , Guicherit Oivin , Huang Buwen , Cui Mei , Liu Chaoting , Huang Zhongdong , Sistla Anand , Yang Jennifer , Murray Brion W.
Published: April 2023

PDF - 165K, Comparison of the effect of PF-2771 and a Eg5/KSP inhibitor on the microtubule network.