bluuebunny/crossref_metadata_2025 huggingface dataset:
En ratas, el consumo de bebidas negras, normales o light, incrementa el peso corporal y la ansiedad
Authors: Eslava-González Laura Lucía , Henao-Pacheco Mabel , Escaño Marisol , Dueñas Zulma
Published: July 2019

El consumo de bebidas negras carbonatadas se asocia con obesidad debido a su alta concentración de azúcar. En efecto, la prevalencia de obesidad, sobre todo en niños, va en aumento, por lo que son pertinentes los estudios de factores de riesgo y los programas de prevención. En este sentido, el objetivo de este estudio piloto fue identificar, en un modelo animal, si el consumo de bebidas negras carbonatadas, normales y de dieta o light, afecta el peso y el comportamiento ansioso. Se seleccionaron 15 ratas Wistar macho, divididas en 3 grupos: un primer grupo de control, que bebía agua exclusivamente; un segundo grupo con suministro de agua y bebida negra carbonatada normal; un tercero con agua y bebida negra carbonatada light. Cada dos días se midió el consumo de bebida y alimento y cada semana se pesaron todos los sujetos. Pasadas cuatro semanas, se evaluaron comportamientos relacionados con ansiedad, utilizando el Laberinto en Cruz Elevado. Se encontraron diferencias significativas estadísticamente en el incremento del peso corporal de las ratas que consumieron bebidas negras normales y light, comparadas con el grupo que solo consumió agua. También se observó mayor consumo de las bebidas carbonatadas, si bien el consumo de alimento se mantuvo en proporciones muy similares para todos los grupos. Con respecto al tiempo de permanencia en los brazos cerrados, fue mayor en las ratas que consumieron bebida light comparadas con el grupo de control y, finalmente, ese mismo grupo mostró menor número de inmersiones de la cabeza en el laberinto. En conclusión, este estudio preliminar permite sugerir que el consumo de bebidas negras carbonatadas, normales y light, se asocia con un incremento del peso corporal de los animales y con mayor ansiedad.
Absceso renal en pediatría: reporte de 2 casos
Authors: Cañas Karen , Galán Gutiérrez Gloria , Orlando Lancheros Diocel , López Pérez Juan José
Published: July 2019

Introducción. Los abscesos renales tras una infección urinaria en pediatría no son frecuentes.Reporte de los casos. Se trata de dos niñas con infección urinaria, de 13 y 8 meses, que desarrollan abscesos renales. En ambas, después de un uroanálisis sugestivo de infección urinaria, se inicia manejo empírico con amikacina. El reporte del urocultivo muestra crecimiento de Escherichia coli (E. coli) >100 000 UFC/ml, sensible a dicho antibiótico, con ecografía renal inicial normal en el primer caso y en el segundo con nefromegalia derecha. A pesar del manejo antibiótico persistió la fiebre por más de tres días, por lo que se sospecha una complicación supurada. En el primer caso, la ecografía renal de control refleja imágenes sugestivas de absceso renal, pero en el segundo, a pesar de ecografías seriadas, solo se reportó la nefromegalia, que llevó realizar una tomografía abdominal con contraste para confirmar el diagnóstico. El antibiótico inicial, a pesar de la sensibilidad in vitro, no fue capaz de controlar la formación de abscesos renales. En el primer caso, el proceso infeccioso se controló utilizando amikacina y ceftriaxona, pero en el segundo fue necesario meropenem y amikacina. En ningún momento se alteró la función renal. Es de anotar lo infrecuente que es el absceso renal en niños en nuestra institución, ya que no se ha encontrado ningún caso en varios años.Conclusiones. El absceso renal en pediatría no es frecuente, se desarrolla principalmente tras una infección urinaria. Son necesarios una alta sospecha y un adecuado diagnóstico para orientar su manejo, ya sea solo médico o asociado a drenaje quirúrgico.
Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications
Authors: Mellati Amir , Akhtari Javad
Published: July 2019

Hydrogels have been used for biomedical applications in recent decades. They are a perfect candidate for regenerative medicine as they resemble the extracellular matrix of native tissues. In addition, their highly hydrated structure makes them a suitable choice for drug and other therapeutics delivery. Injectable hydrogels have increasingly gained attention due to their capability for homogeneous mixing with cells and therapeutic agents, minimally invasive administration, and perfect defect filling. In this review, we discuss various mechanisms which facilitate injectability of hydrogels, including in situ gelling liquids, injectable gels, and injectable particles. Then, we explore the biomedical applications of injectable hydrogels, including tissue engineering, therapeutic agent delivery, and medical devices.
The Cold War in the Middle East in the Second Half of the 1950s: What was the Soviet Response Against Western Interventionism?
Authors: BEKCAN Umut
Published: July 2019

This study aims to look from
the Soviet Union’s perspective to the attempts
of western capitalist states intending to maintain their domains in the period,
in which the Suez Crisis and the Eisenhower doctrine dominated the region; to
reveal how the Soviet Union assessed the developments and to clarify its
position. The
Soviet Union responded to the West with an anti-imperialist policy. In this context, this policy of the Soviet
Union against the interventionist policies of the western
capitalist states in the Middle East defending  the independence and sovereignty of states in
the region constitutes the main research
problem of this study.
Raport generalny – Transformacja systemów podatkowych w państwach Europy Środkowo-Wschodniej – 25 lat doświadczeń oraz wyzwania na przyszłość – cz. II
Authors: Nykiel Włodzimierz , Kukulski Ziemowit
Published: July 2019

Niniejszy raport generalny powstał jako rezultat międzynarodowej konferencji nt. The Transformation of Tax Systems in the CEE and BRICS Countries – 25 years of experience and future challenges zorganizowanej przez Centrum Dokumentacji i Studiów Podatkowych Uniwersytetu Łódzkiego we współpracy z Międzynarodowym Biurem Dokumentacji Podatkowej w Amsterdamie (International Bureau of Fiscal Documentation (IBFD) in Amsterdam), Fundacją Centrum Dokumentacji i Studiów Podatkowych, Polskim Oddziałem Międzynarodowego Stowarzyszenia Podatkowego (Polish Branch of International Fiscal Association, IFA). Konferencja ta odbyła się w dniach 9–10 października 2015 r. na Wydziale Prawa i Administracji Uniwersytetu Łódzkiego. Raport dotyczy ogólnych i szczegółowych aspektów transformacji systemów podatkowych i polityki podatkowej w państwach Europy Środkowej i Wschodniej w latach 1990–2015 w różnych obszarach prawa podatkowego: materialnego, proceduralnego oraz międzynarodowego. W raporcie zidentyfikowano także przyszłe wyzwania stojące przez systemami podatkowymi państw Europy Środkowej i Wschodniej. Zidentyfikowanie doświadczeń państw Europy Środkowej i Wschodniej na polu transformacji ich systemów podatkowych oraz przyszłych wyzwań jest krokiem niezbędnym na drodze do tworzenia lepszej legislacji podatkowej, przystającej do potrzeb podatników i administracji podatkowej we współczesnym świecie. W raporcie omówiono m.in. zagadnienia związane z relacjami między prawem konstytucyjnym a prawem podatkowym, standardy legislacji podatkowej, standardy i koncepcje polityki podatkowej państw Europy Środkowej i Wschodniej, problematykę oporu podatkowego, znaczenie i konstrukcję poszczególnych podatków, podatkowe aspekty zachęt podatkowych dla działalności badawczej i rozwojowej i innych ulg podatkowych, a także rodzajów interpretacji przepisów prawa podatkowego, proceduralnych gwarancji ochrony praw podatników i ich skuteczności. Ponadto w raporcie przeanalizowano rolę i znaczenie jednostronnych, dwustronnych i wielostronnych środków zapobiegających podwójnemu opodatkowaniu, w tym wpływ Konwencji Modelowej OECD w sprawie podatku od dochodu i kapitału, Konwencji Modelowej ONZ w sprawie unikania podwójnego opodatkowania między państwami rozwiniętymi a rozwijającymi się oraz OECD/G20 Planu Działań BEPS.
Consumo de plantas pioneras por murciélagos frugívoros en un fragmento de bosque seco tropical (Colombia)
Authors: García Herera Leidy Viviana , Ramírez Fráncel Leidy Azucena , Reinoso Flórez Gladys
Published: July 2019

La dispersión de semillas es una de las interacciones planta-animal más importante en la dinámica de comunidades vegetales y el mantenimiento de la diversidad de plantas en los bosques tropicales; ya que, mediante este mecanismo, las plantas encuentran la posibilidad de colonizar nuevos sitios y mantener la estructura poblacional. Por lo anterior, se evaluó la preferencia en la dieta de las especies de murciélagos frugívoros de un bosque seco. El análisis de 63 registros dietarios de 14 especies de murciélagos permitió identificar 11 especies, tres géneros y una morfoespecie de frutos dispersados, de los cuales Bidens pilosa, Piper crassinervium y Physalis peruviana L. fueron las especies más explotadas. Artibeus planirostris presentó la mayor amplitud de dieta seguido por Dermanura phaeotis. Se presentó sobreposiciones de dieta bajas debido a que la dieta se centró en plantas con patrones de fructificación continuos. Se resalta el consumo de frutos en estado sucesional arbusto, lo cual confirma el papel clave de los murciélagos en la dispersión de especies pioneras.
Whitehead, CD Projekt RED e desenvolvimento de jogos: entrevista com Marcin Blacha
Authors: Fragoso Suely , Amaro Mariana , Lane Ian Wason
Published: July 2019

Entrevista com Marcin Blacha, designer de jogos e Diretor de Narrativa do estúdio CD Projekt RED sobre as conexões entre os estudos acadêmicos e o desenvolvimento de jogos. Blacha aborda a aproximação da Filosofia de Whitehead e o design de jogos, assim como temas referentes as singularidades dos jogos desenvolvidos fora do eixo anglófono.
Ficção como jogo: reavaliando a relação entre jogos, jogar e ficção
Authors: Deterding Sebastian
Published: July 2019

Os game studies há muito tempo vêm debatendo como relacionar os elementos ficcionais e os do jogo nos videogames. Este artigo propõe que muitos dos desafios conceituais nesse debate podem ser solucionados se os jogos e a ficção não forem tratados separadamente, mas como formalizações específicas de um mesmo fenômeno comum: o jogar. O artigo apresenta cinco propostas teóricas dessa perspectiva de jogo-e-ficção-como-jogar (JEFCJ), segundo a qual tanto os jogos quanto a ficção apresentam mais semelhanças que diferenças. Ele extrai os princípios e vantagens compartilhadas por essa abordagem JEFCJ, e como isso ajuda a explicar tanto os pontos em comum, quanto as diferenças entre a ficção e os jogos.
Ação como base para uma estética da subjetividade lúdica
Authors: Vella Daniel
Published: July 2019

A relevância de reconhecer o senso de agência como sendo fundamental para a experiência da jogadora ao se engajar com o mundo do jogo já foi apresentada com frequência. Neste artigo, eu gostaria de examinar a ideia de que a ação constitui o eu próprio da jogadora, isto é, o senso de quem ela é em relação ao mundo do jogo. Para este fim, a observação concentra-se em jogos nos quais a jogadora se incorpora ao mundo do jogo na forma de uma única figura jogável, estabelecendo uma posição-subjetiva lúdica incorporada na qual ela aciona a subjetividade lúdica. O primeiro passo para fundamentar a análise dessa atualização da subjetividade lúdica foca na conceituação da relação entre ação e sujeito. A identificação de um esquema conceitual para atacar esta questão pavimentou o caminho para abordagens da ação por ambas as tradições da filosofia, analítica e continental. Ao seguir esse direcionamento, o artigo argumenta que a estrutura experimental do gameplay de jogos digitais se organiza em torno da interação entre a perspectiva interna do mundo do jogo – aquela da posição-subjetiva lúdica – e uma perspectiva externa, distanciada, permitindo que a atualização da subjetividade lúdica da jogadora torne-se visível e estruturando uma estética da subjetividade lúdica que é inseparável – e, de fato, consequente à tomada de ações que a jogadora exerce no mundo do jogo.
Empresas Transnacionais: Sustentabilidade Econômica, Ética e Compliance
Authors: Gonzaga Alvaro Luiz T. de Azevedo , Vailatti Diogo Basilio
Published: July 2019

O presente trabalho tem por objetivo entrelaçar as ideias de sustentabilidade econômica, ética empresarial e compliance com um dos principais atores da Economia no mundo globalizado: a empresa transnacional. Nas últimas décadas, as empresas transnacionais desenvolveram-se de forma exponencial, o que faz com que diversos debates sobre os limites de sua atuação sejam cada vez mais necessários para a concretização dos Direitos Humanos. E é justamente dentro desta questão que presente pesquisa buscará analisar o papel da empresa transnacional na efetivação dos Direitos Humanos, partindo das ideias de sustentabilidade econômica, ética e compliance. Os métodos de pesquisa utilizados serão o hipotético-dedutivo, bibliográfico e revisional.
La Protección del Contratante Débil en los Contratos en los que No Interviene un Consumidor
Authors: González Dolores Palacios
Published: July 2019

La falta de transparencia de una condición general de la contratación, entendida como falta de conocimiento de las consecuencias económicas del contrato que se está aceptando, debería llevar a que no se considere integrada en el mismo con independencia de que uno de los contratantes sea o no consumidor. Esto lo permite, a mi juicio, el control de incorporación de la Ley de Condiciones Generales de la Contratación. Si, como hace el Tribunal Supremo, la falta de transparencia se anuda a la abusividad y solo pueden ser declaradas nulas por abusivas las cláusulas de los contratos de consumo, se tratará de manera diferenciada a adherentes que pueden encontrarse en la misma situación por el hecho de que actúen o no en el marco de su actividad comercial, empresarial, oficio o profesión. Y eso, en muchos casos, no está justificado.
Tratamento Jurídico-Penal do “Contrabandista” de Medicamentos, o Paraguai e a Fronteira Oeste do Paraná
Authors: Esquivel Carla Liliane Waldow , Esquivel Héctor Luis Lovera , Leopoldino Candida Joelma
Published: July 2019

O grave problema do contrabando, especialmente realizado através da fronteira entre o Paraguai e os municípios localizados na região Oeste do Paraná, tem diversas repercussões, inclusive de natureza econômica-social. No entanto, a internalização no país de medicamentos controlados ou até mesmo proibidos reflete inevitavelmente na saúde da população, podendo gerar comprometimentos à integridade física e até mesmo à vida dos consumidores. A criminalização desse comportamento, pelo direito penal brasileiro, merece particular atenção, especialmente diante da possibilidade de adequar-se a diferentes comandos normativos. Desta feita, o presente estudo teve por escopo, além de destacar a seriedade do problema do contrabando de medicamentos a partir do Oeste do Paraná, sua repercussão na saúde pública nacional e as diferentes formas de responsabilidade penal a que o autor possa ser submetido, podendo ocorrer a subsunção ao descrito no art. 273, § 1º-B ou no 334-A, ambos do Código Penal, ou no art. 33 da Lei 11.340/2006. Para alcançar tais objetivos, foi realizada uma pesquisa qualitativa e teórica (hipotético-dedutiva), com abordagem interdisciplinar, mas com ênfase na investigação jurídico-penal.
Las Empresas y la Protección de los Derechos Humanos en el Sistema del Consejo de Europa
Authors: Ushakova Tatsiana
Published: July 2019

El estudio tiene como objetivo el análisis de la posición de las empresas, y en especial las multinacionales, entre los sujetos y actores del Derecho internacional. Para describir dicha posición, se hace referencia a los cuatro elementos de la personalidad jurídica internacional, a saber, la legitimidad activa, la legitimidad pasiva, los privilegios e inmunidades en el plano internacional y la participación en el proceso de creación de las normas internacionales. Una atención particular se presta al estudio de la capacidad de las empresas para tener derechos y obligaciones y hacer valer estos derechos y responder por sus obligaciones en el sistema de protección de los derechos humanos del Consejo de Europa.
The Role of Pili Protein 38,6 kDa Klebsiella pneumoniae as a Hemagglutinin and Adhesin Protein which Serves as a Virulence Factor
Authors: Finka Regina , Agustina Dini , Rachmawati Dwita Aryadina , Suswati Enny , Mufida Diana Chusna , Shodikin Ali
Published: July 2019

Klebsiella pneumoniae is an infectious bacteria in various parts of the body. The presence of proteins in pili that will bind to cell surface receptors (adhesin proteins) and cell membrane sugar molecules (hemagglutinin proteins) is a very influential factor in the ability of K. pneumoniae to enter the human body. The purpose of this study was to determine the role of pili 38.6 kDa K. pneumoniae protein as a hemagglutinin and adhesin protein which functions as a virulence factor. This type of research is pure experimental research using the electrophoresis method (SDS-PAGE) to obtain protein. The protein obtained was then tested for hemagglutination and adhesion test using erythrocyte cells and enterocytes of BALB / C mice to determine their role as hemagglutinin and adhesin proteins. Conclusion of this study pili protein 38.6 kDa Klebsiella pneumoniae acts as a hemagglutinin and adhesion protein which functions as a virulence factor.

Keywords: Klebsiella pneumonia, 38,6 kDa Protein, Hemagglutinin, Adhesin
An Early PDP Connectionist Model for Describing the Behavioral Phenomenon
Authors: Panassiol Ricardo Tiosso
Published: July 2019

The focus of modern neuroscience on cognitive processes has relegated to behavior the epiphenomenal status of neural processing and the difficulties generated by this interpretation have encouraged the use of computational models. However, the implementation based on inferred cognitive constructs has been inefficient. The objective of this work was to review the concept of behavior by a selectionist approach and propose a connectionist computational model that operates integrally with its neurophysiological bases. The behavioral phenomenon was functionally defined and described at different levels of analysis. Functional levels make it possible to understand why behavioral phenomena exist, while topographic levels describe how morphophysiological mechanisms implement the response. The connectionist notions of PDP ANNs formalizes the proposal. The model stands out for contextualizing neural processing as part of the response, addressing the behavioral phenomenon as a whole that needs to be explained in its most different levels of analysis.
ASSET PRICE SHOCK RESPONSE TO SHOCK CAPITAL FLOW, EXCHANGE RATE AND INTEREST RATE: CASE STUDY OF 16 EMERGING MARKET COUNTRIES
Authors: Guswardi Rachman
Published: July 2019

Capital flows to developing countries and emerging markets in the world is constantly increasing. However, the crisis that occurred in 2008 and 2011 caused concern for investors. A series of policies have been carried out in several emerging market countries to take steps prudence in controlling capital flows. This study aimed to analyze the response of asset prices to the shock caused by capital inflows, interest rates and exchange rates and analyzes the contribution of shock in capital inflows, interest rates and exchange rates on asset prices in 16 emerging market countries (India, Brazil, Russia, Indonesia, Republic of South Africa, Mexico, Thailand, South Korea, Colombia, Philippines, Egypt, Hong Kong, Peru, Czech, Bangladesh, Hungary) in the year 2001-2015. The method used is quantitative method using Panel Vector Auto Regression models. The results of this study show that the first shock of positive capital inflows will affect asset prices, both that a positive shock on interest rates will affect asset prices, the third that the positive shock of the exchange rate would affect asset prices. The variables that have the biggest contribution in influencing asset prices is the exchange rate which further interest rates and the smallest is the capital inflows.
Efficiency of Government Spending For Human Development Some Districts in Central Java During 2008 - 2012
Authors: Atmanti Hastarini Dwi
Published: July 2019

Human development is a good indicator to measure the progress of a nation.Welfare of a nation measured not only from the gross domestic product, but also from the human development aspect, which include education and public health. The paper represented education and health aspect by the Human Development Index (HDI) while the economic performance is reflected by the value of Purcashing Power Parity (PPP) index. This study analyzes the efficiency of government spending on human development using Data Envelopment Analysis (DEA). The study shows that the level of efficiency of government spending on human development in some districts in Central Java during 2008 – 2012 is more than 90%.
THE RELATIONSHIP BETWEEN NUMBERS OF INTERNATIONAL TOURIST ARRIVALS AND ECONOMIC GROWTH IN THE ASEAN-8: PANEL DATA APPROACH
Authors: Anggraeni Garnis Nur
Published: July 2019

In an open economy, economic growth is not only supported by international trade but may also be supported through the development of tourism. We can use international tourist arrivals as one of indicators of international tourism. This study aimed to examine the factors that influence international tourist arrivals as well as to analyze the relationship between the number of international tourist arrivals and economic growth in the Southeast Asian regions. This study uses panel data regression to 8 ASEAN countries during the period of 2000 to 2012. The results showed that the variables that identified as the determinant of international tourist arrivals are GDP per capita, secondary education enrollment gross ratio, and life expectancy. Furthermore, the number of international tourist arrivals have a significant effect on economic growth in conform with tourism-led economic growth hypothesis (TLGH). This finding infers that tourism sector could be developed as an effort to increase economic growth.Keywords: International Tourism, Economic Growth, International Tourist Arrivals, TLGH,Panel DataSubject/Object of research: Indonesia, Malaysia, Singapore, Philippines, Thailand, Vietnam,Cambodia, Lao PDR
PROPERTY PRICE BUBBLE: REGIONAL ANALYSIS IN INDONESIA
Authors: Kurniawan Indra
Published: July 2019

The aim of this study is to look at the influence of fundamental factors of demand and supply side of the property prices in five major Cities in Indonesia using data panel regression methods. In addition, this study analyzes the regional property and the price bubble in Indonesia using the Hodrick Prescott filter analysis. The results of the panel data regression method Showed that the demand-side fundamentals such as economic growth and inflation have a positive effect on property prices as well as interest rate, while  the loan to value(LTV) Negatively Affect the price of the property. On the other hand, the fundamental factors of supply-side variable, that is developer’s price expectations impact positively the price of the property. HP filter analysis identifying the bubble in every city that lasted for two periods during the study.
East Java Growth Dynamics: Need More Physical Capital or Quality of Labor? The Case of Manufacturing Sector
Authors: AFIN RIFAI
Published: July 2019

This paper identifies the dynamic pattern of East Java growth of manufacturing sector and addresses the basic questions of individual economic firms whether they would be better off if increasing physical capital or investment in human capital. To know which one of the two main inputs in industrial sector that is more needed than the other, the marginal productivity of each production factors must be identified. I estimate the models which accommodate the optimum input level searching by applying general method of moment (GMM) and panel instrumental variable (IV) techniques on some reduced form models. I find that on the demand function of labor and capital as the first step of IV or Two Stage Least Square (2SLS) show that the elasticity of both of them are inelastic and elasticity of labor demand is more sensitive than capital. In the production function as the second step, yields that the most productive production factors is labor so that investment in this factor production is beneficial for industrial growth in East Java. On the other side, the physical capital has not been reached the optimum level but the elasticity of capital in production is low. Hypothetically, the inelasticity of physical capital is because macroeconomic aspects which is monetary policy and expected economic situation. Considering these two arguments, quality of labor should be more concerned in the context of regional economy of East Java because capital aspect cannot be interfered at regional level at least for large capital scale.Keywords: Capital, Labor, Growth, General Method of Moment (GMM), Instrumental Variable (IV)
IDENTIFIED OF TOBACCO INDUSTRY DEVELOPMENT IN EAST JAVA: ERROR CORRECTION MODEL APPROACH AND THE TRIPLED LAYER BUSINESS CANVAS MODEL APPLICATION
Authors: Mu'min M Silahul , Anggara Yoga Pury , Maulana Reza Bagas
Published: July 2019

The agricultural sector is one of the main sectors in the Indonesian economy in addition to the industrial sector and the trade sector. In addition to the purpose of meeting the basic needs of the community, the agricultural sector also contributes to the Indonesian economic structure. In 2018, BPS (Central Statistics Agency) noted that the agricultural sector contributes 14% to GDP (Gross Domestic Product). East Java Province has enormous potential for the development of the agricultural sector today. Agriculture is still a leading sector for the economy of East Java in the digital era as it is today. Tobacco is one of the agricultural derivatives commodities that have an important contribution in the economy. Based on data from the Central Statistics Agency (BPS) from 2010-2016, there are four regions with large tobacco production in East Java, namely Jember, Probolinggo, Situbondo and Bojonegoro, which account for 2.01% of Java's Gross Regional Domestic Product (GRDP) East in 2016 with a gross added value of Rp. 27,321 billion. Business competition in the current digital economy era requires industry to be able to try to increase production capacity in the face of competition with similar industries. The purpose of this study is to analyze the factors that influence the development of the tobacco industry both in the short and long term and provide recommendations for sustainable and competitive tobacco industry development policies. This study uses the Panel Vector Error Correction Model (PVECM) method and the preparation of industrial development recommendations based on the Triple Layered Business Model Canvas (TLBMC). The results showed that the level of GRDP and land productivity were the main factors influencing the development of the tobaccoindustries and canvas in TLBMC capable of being the basis for supporting the development of the tobacco industry that is more holistic in the orientation of sustainable innovation business by considering three perspectives namely economic, environmental, and social impacts.
FACTORS INFLUENCING PROFIT EFFICIENCY OF BANKING IN INDONESIA
Authors: Kadang Juliana
Published: July 2019

This study intends to test, analyze, and verify the influence of bank size, capital adequacy, liquidity, credit risk, and market power on commercial banks profitability. Quantitative research methods applied in this study are explanatory method, which aims to analyze the influence of independent variables on dependent variable and descriptive method to describe the object studied. The study also applies Stochastic Frontier Analysis (SFA) approach to estimate the technical efficiency of commercial banks. The results show that bank size, capital adequacy (CAR), liquidity (LDR), credit risk (NPL) and market power significantly affect the profitability of commercial banks in Indonesia in the period of 2010-2016. The result of yearly financial report of each bank is caused by the fact that: 1). some banks are in the process of mergers; 2). the allowance for impairment losses on financial assets and non-financial assets increased primarily with banks in the merger process; 3). banks have credits in default status and under special surveillance with an increasing amount of credits from year to year.
INPUT-OUTPUT ANALYSIS: A CASE STUDY OF TRANSPORTATION SECTOR IN INDONESIA
Authors: Muryani Muryani , Swastika Rosario Bedi
Published: July 2019

This study Aimed to analyze the transport linkages and multiplier effects of each subsector of transport when there is a change in the budget of the transport sector in the Indonesian economy. This study uses an analytical tool input - output models of Indonesia in 2010, with 185 sectors. Input - output models is used to analyze the relationship backwards and forwards in the transport sector of the Indonesian economy and the multiplier effect on the Indonesian economy as a whole. Results of the analysis Showed that the transport has a total backward linkage high while total forward linkage of transport is relatively low. This is an indication that transportation plays in attracting and developing the upstream sector, but less instrumental in developing the downstream sector. The results Obtained from the analysis of the output multiplier effect when a decline in the transport sector budget has a high value, while the income multiplier and labor multiplier when a decline in the transport sector budget has a low value. This shows a Decrease in the budget in the transport sector can reduce the production output of the Indonesian economy but less budget reduction effect on income and employment.
Saber tocar e saber ensinar: os saberes mobilizados na prática pedagógica do professor de instrumento
Authors: Weber Vanessa
Published: July 2019

Este artigo apresenta resultados de uma pesquisa realizada em nível de mestrado que teve como objetivo geral compreender o processo de construção da docência de instrumentistas bacharéis que atuam como professores de instrumento. São abordados, especificamente, os resultados referentes aos saberes docentes mobilizados durante a prática pedagógica do bacharel em instrumento. Metodologicamente, adotou-se a investigação biográfico-narrativa (BOLÍVAR; DOMINGO, 2006), por meio da qual foram produzidas narrativas de três bacharéis formados pela UFSM, professores de instrumento. Como referencial teórico, a investigação teve como base estudos de Gauthier et al. (2006) e Tardif (2012). Com relação aos saberes mobilizados na prática pedagógica, percebemos que os professores, de alguma forma, mobilizam os saberes descritos por estes autores, dentre os quais: saberes da tradição pedagógica, disciplinares, curriculares, experienciais, das ciências da educação e saberes da ação pedagógica; e saberes específicos aos professores de instrumento, como o saber da função educativa (ARAÚJO, 2006), referente às metodologias e à didática empregada especificamente para o ensino de instrumento. Além disso, a pesquisa avança no conhecimento ao identificar um saber ainda não apontado no contexto do professor de instrumento, saber este relacionado a aspectos da técnica, expressão musical, além do preparo físico e emocional para a apresentação pública, o qual denominamos “saber da performance”.
THE DIFFICULTIES OF EARLY DIAGNOSIS AND TREATMENT OF BOTULISM
Authors: Nikiforov V. V. , Tomilin Yu. N. , Chernobrovkinya T. Ya. , Yankovskaya Y. D. , Burova S. V.
Published: July 2019

The popularity of home canning contributes to a sufficiently high incidence of botulism worldwide. The canned products containing botulinum toxin do not change neither color, taste, nor smell of contents of canned food. The criteria for the severity of the course of botulism are considered a violation of swallowing liquid food and symptoms of difficulty breathing. A distinctive feature of the paralytic syndrome in botulism is its symmetry and the absence of a violation of sensitivity. The criteria of the severity of the course of botulism is considered a violation of swallowing liquid food and the severity of acute respiratory failure. The paper presents the features of the therapy of the patients with botulism in the intensive care unit. Clinical examples illustrate the difficulties in recognizing botulism at the early stage of the disease, which are due to the polymorphism of the clinical picture of botulism and the similarity of symptoms with other diseases. Most commonly, patients with botulism are diagnosed with acute intestinal infection or the neurological pathology. Patients are not hospitalized in a timely manner, which can affect the outcome of the disease. The ability to recognize botulism at the prehospital stage is necessary for all doctors.
EATING DISORDERS IN PATIENTS WITH CHRONIC GASTRITIS AND TYPE 2 DIABETES MELLITUS
Authors: Kazarin D. D. , Shklyaev A. E. , Gorbunov Yu. V.
Published: July 2019

Diabetes mellitus holds one of the leading positions among the current problems of modern medicine. Despite the obvious success in studying diabetes in the last decades, its prevalence has become pandemic. In spite of the use of modern methods of therapy, a rather high frequency of diabetes mellitus complications from various organs and systems, the pathological changes in which largely determine the course of the disease and patient’s quality of life remains. Issues of eating disorders and their correction play an important role in the complex therapy of patients with diabetes mellitus. Objective: determination of the characteristics and relationship of eating disorders with gastroenterological symptoms and glucose levels in patients with chronic gastritis in type 2 diabetes. Materials and methods: dynamic study of the eating behavior and quality of life in 66 patients with chronic gastritis in type 2 diabetes mellitus was conducted using GSRS, SF-36 and DEBQ questionnaires. The level of glucose on an empty stomach and after eating was also measured, the frequency of self-measurement of glucose level and the presence of diabetes mellitus complications were determined. Results: the identified correlation relationships suggest that gastrointestinal symptoms characteristic of chronic gastritis with type 2 diabetes mellitus worsen the physical and psychological components of health, which provokes a breakdown and a violation of the diet in this category of patients. Conclusion: chronic gastritis in patients with type 2 diabetes mellitus aggravates the prognosis of diabetes and exacerbates eating disorders, which requires observation of an endocrinologist, as well as a gastroenterologist and psychotherapist in the management of such patients.
AMBULATORY ARTERIAL STIFFNESS MONITORING IN PATIENTS WITH ASTHMA
Authors: Karoli N. A. , Zarmanbetova O. T. , Rebrov A. P.
Published: July 2019

Cardiovascular disease is one of the major causes of death throughout the world. Early detection of target organ damage is important for more successful prevention of cardiovascular diseases and improvement of patient outcomes. One of these target organs is the vascular wall, and its damage consists in loss of elastic properties and increase in stiffness. Many studies have shown that the increasing stiffness of the vascular wall is an independent predictor of cardiovascular risk. Objective: To evaluate parameters of the ambulatory arterial stiffness monitoring in patients with bronchial asthma. Materials and methods. The study enrolled 119 patients with asthma. The group of control included 30 practically healthy volunteers comparable by gender and age with the patients of the main group. Each patient underwent ambulatory blood pressure and arterial stiffness monitoring using BPLab MnSDP-2 device (Petr Telegin, Russia). Results: In patients with asthma higher values of augmentation index, arterial stiffness index and pulse wave velocity in the aorta in comparison with patients of the control group, as well as violation of the 24-hour profile of arterial stiffness were noted. Conclusion. Patients with asthma demonstrated significantly increased arterial stiffness in comparison with control group.
Avaliação energética da maravalha gerada em uma serraria de pequeno porte
Authors: Moulin Jordão Cabral , Arantes Marina Donária Chaves , Gonçalves Fabricio Gomes , Paes Juarez Benigno , Baraúna Edy Eime Pereira , Rosa Rafael Amorim
Published: July 2019

O trabalho teve como objetivo realizar a quantificação e qualificação energética da maravalha gerada em uma serraria do município de Jerônimo Monteiro/ES, esse material foi composto por uma mescla de diversas madeiras. Foram realizadas visitas técnicas na serraria duas vezes por mês com intuito da realização da análise quantitativa, e para a coleta de três amostras para a realização das análises de umidade, densidade a granel, análise química, teor de cinzas, análise elementar e o poder calorífico. Concluiu-se que a densidade a granel da maravalha analisada é apropriada para produção de briquete, verificou-se que este resíduo é adequado para a produção de energia.
Avaliação do efeito curativo e preventivo do óleo essencial do capim citronela no controle de Pyricularia grisea
Authors: Perini Vilma Borges de Moura , Castro Henrique Guílhon de , Santos Gil Rodrigues dos , Aguiar Raimundo Wagner de Souza , Leão Evelynne Urzêdo , Seixas Paula Tatiana Lopes
Published: July 2019

A brusone é a doença de maior importância da cultura do arroz, devido aos prejuízos que causa na produtividade e na qualidade dos grãos. Visando o emprego de óleos essencial e extratos vegetais no controle desta doença, objetivou-se com este trabalho avaliar o efeito curativo e preventivo de extratos e óleo essencial do capim citronela (Cymbopogon nardus L.) no controle da brusone do arroz. A avaliação do efeito curativo foi realizada após sete dias da pulverização com os extratos do capim citronela. Quanto à avaliação do efeito preventivo, as plantas foram pulverizadas com os tratamentos e após 24 horas inoculadas com 20mL da solução de esporos por bandeja. Na avaliação do efeito curativo, verificou-se que com a aplicação do fungicida e do óleo essencial diluído do capim citronela na concentração de 2% as plantas não apresentaram sintomas da brusone em 50% das repetições. Em relação à avaliação do efeito preventivo, as plantas não apresentaram sintomas da doença nas concentrações de 1,5; 1,75 e 2% do óleo essencial do capim citronela em 50% das repetições.
Self-Regulation of Memory CD8 T Cell Metabolism through Extracellular ATP Signaling
Authors: Wanhainen Kelsey M. , Jameson Stephen C. , da Silva Henrique Borges
Published: July 2019

Following activation, CD8 T cells transition from reliance on mitochondrial respiration to increasing utilization of aerobic glycolysis. After the effector phase, however, reversion to mitochondrial metabolism is pivotal generating memory CD8 T cells. We recently showed that sensing of extracellular ATP (eATP) through the receptor P2RX7 is crucial for both production and the long-term survival of memory CD8 T cells, evidently through promoting mitochondrial maintenance. Unexpectedly, these results indicated that sustained P2RX7 activation is required for memory CD8 T cell homeostasis, suggesting constant exposure to eATP, in contrast with the proposed role of eATP as an acute "danger" signal released by dying cells. Active release through transmembrane channels is another path for eATP export. Indeed, CD8 T cells express Pannexin 1 (Panx1) which has a reported eATP release functionin vitroand is itself induced by P2RX7 and/or TCR engagement. Such a role for Panx1 could potentially provide a feed-forward mechanism for cell-autonomous P2RX7 signaling. This model envisages that memory CD8 T cells maintain themselves at the cost of reduced intracellular ATP levels, which at first glance would seem to be detrimental for sustained T cell maintenance. On the other hand, the need to tightly regulate levels of intracellular ATP may be critical for the durability and adaptability of memory CD8 T cells, hence engagement of the P2RX7/Panx1 axis may allow these cells to fine tune their metabolic status to meet changing demands. In this Perspective, we discuss how this pathway may influence memory T cell maintenance.
Molecular Mechanisms of Adipogenesis: The Anti-Obesogenic Role of AMP-Activated Protein Kinase and Recently Reported Plant Products
Authors: Ahmad Bilal , Serpell Christopher , Lim Isabel Fong , Wong Eng Hwa
Published: July 2019

The Abnormal increase in the mass of adipose tissue during adipogenesis results in obesity. Obesity is a predominant disorder and its widespread has become a critical concern worldwide. This is due to the burden of its associated co-morbidities like cancer, cardiovascular diseases and diabetes. Over-nutrition and the sedentary lifestyle are considered as the most significant causes of abnormal adipose tissue development. Appropriate lifestyle and behavioural interventions are the corner stones of successful weight loss, but to maintain such a lifestyle is highly challenging. Accordingly, natural products from plants either as crude extracts or purified phytochemicals have shown to have anti-obesogenic properties and are generally non-toxic and cost-effective. In this review, we discuss the comparative analysis of molecular mechanisms involved in adipogenesis and the recently reported anti-obesogenic effects of various plant products. We will provide a common platform for understanding obesity and adipogenesis, and a possible mechanism of action for anti-obesogenic plant products through AMP-activated protein kinase (AMPK), which will support the scientific development of traditional herbal medicine.
An Integrated Pan-Cancer Analysis and Structure-Based Virtual Screening of GPR15
Authors: Wang Yanjing , Wang Xiangeng , Xiong Yi , Li Cheng‐Dong , Xu Qin , Shen Lu , Chandra Kaushik Aman , Wei Dong-Qing
Published: July 2019

G protein-coupled receptor 15 (GPR15, also known as BOB) is an extensively studied orphan GPCR involving HIV infection, colonic inflammation and smoking-related diseases. Recently, GPR15 was deorphanized and its corresponding natural ligand demonstrated an ability of inhibiting cancer cell growth. However, no study reported the potential role of GPR15 in a pan-cancer manner. Using large-scale publicly available data from the Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases, we found that GPR15 expression is significantly lower in colon adenocarcinoma (COAD) than in normal tissues. And among 33 cancer types, GPR15 expression is significantly correlated with the prognoses of COAD, neck squamous carcinoma (HNSC), lung adenocarcinoma (LUAD) positively and stomach adenocarcinoma (STAD) negatively. This study also revealed that commonly upregulated gene set in the high GPR15 expression group (stratified via median) of COAD, HNSC, LUAD and STAD are enriched in immune systems, indicating that GPR15 might be considered as a potential target for cancer immunotherapy. Furthermore, we modelled the 3D structure of GPR15 and conducted the structure-based virtual screening. The top 8 hits compounds were screened and then subjected to molecular dynamics (MD) simulation for stability analysis. Our study provided novel insights into the role of GPR15 in a pan-cancer manner and discovered a potential hit compound for GPR15 antagonists.
Experimental Estimation of Temporal and Spatial Resolution of Coefficient of Heat Transfer in a Channel Using Inverse Heat Transfer Method
Authors: Karami Majid , Davoodabadi Farahani Somayeh , Kowsary Farshad , Mosavi Amir
Published: July 2019

In this research, a novel method to investigation the transient heat transfer coefficient in a channel is suggested experimentally, in which the water flow, itself, is considered both just liquid phase and liquid-vapor phase. The experiments were designed to predict the temporal and spatial resolution of Nusselt number. The inverse technique method is non-intrusive, in which time history of temperature is measured, using some thermocouples within the wall to provide input data for the inverse algorithm. The conjugate gradient method is used mostly as an inverse method. The temporal and spatial changes of heat flux, Nusselt number, vapor quality, convection number, and boiling number have all been estimated, showing that the estimated local Nusselt numbers of flow for without and with phase change are close to those predicted from the correlations of Churchill and Ozoe (1973) and Kandlikar (1990), respectively. This study suggests that the extended inverse technique can be successfully utilized to calculate the local time-dependent heat transfer coefficient of boiling flow.
THE EFFECTS OF SOCIAL FACTORS ON THE ADOPTION OF RICE PRODUCTION TECHNOLOGIES IN ZONE C OF BENUE STATE, NIGERIA
Authors: Ejembi S A , F Orkpe , G.O Bello
Published: July 2019

AbstrakPenduduk  Nigeria seperti pada bagian lain dunia terus melambung sehingga memerlukan peningkatan produktivitas pertanian dan ketahanan pangan. Untuk memenuhi  kebutuhan pangan, perlu dilakukan peningkatan produksi melalui teknologi yang tepat. Di sebagian besar wilayah Nigeria, adopsi teknologi pertanian masih rendah. Penelitian ini bertujuan untuk menganalisa pengaruh karakteristik sosial petani terhadap keputusannya mengadopsi teknologi produksi padi. Penelitian dilakukan di Zona C dari Negara Bagian Benue yang dipilih secara purposif karena di daerah ini tersedia  areal pertanian  yang sesuai untuk pertanaman padi. Seratus responden dipilih melalui teknik simple random sampling. Statistik deskriptif (persentase dan frekuensi) dan statistik inferensial (Model Regresi Biner Logit) digunakan untuk analisis data. Hasil penelitian menunjukkan bahwa mayoritas reponden (55%) adalah laki-laki, 48% memiliki pengalaman bertani antara 6-20 tahun, 49% memiliki kualifikasi pendidikan tersier, 62% bukan berasal dari kelompok tani, 51% tidak memiliki kontak  dengan penyuluh dan 56 % responden memperkirakan pendapatan tahunan mereka rata-rata ₦ 120, 000.00. Pada umumnya responden memperoleh informasi pertanian utama melalui radio, 93% mengungkapkan bahwa teknologi  benih merupakan teknologi utama yang tersedia bagi petani. Hasil regresi logit menunjukkan bahwa pendidikan (W = 9.600), dan luas lahan (W = 2.051) secara signifikan mempengaruhi keputusan adopsi petani. Berdasarkan temuan ini, disimpulkan bahwa tingkat adopsi yang rendah karena tidak adanya teknologi baru selain benih yang lebih baik, dan juga tidak adanya penyuluhan. Oleh karena itu, direkomendasikan agar organisasi petani diperkuat agar mereka dapat mengatur layanan penyuluhan mereka sendiri. Kata Kunci: adopsi teknologi; faktor sosial; teknologi baru; penyuluhan pertanian