bluuebunny/crossref_metadata_2025 huggingface dataset:
Organic acidemias in the neonatal period: 30 years of experience in a referral center for inborn errors of metabolism
Authors: Unsal Yagmur , Yurdakok Murat , Yigit Sule , Celik Hasan Tolga , Dursun Ali , Sivri Hatice Serap , Tokatli Aysegul , Coskun Turgay
Published: October 2022

Objectives

Neonatal-onset organic acidemias (OAs) account for 80% of neonatal intensive care unit (NICU) admissions due to inborn errors of metabolism. The aim of this study is to analyze clinical features and follow-up of neonates diagnosed with OAs in a metabolic referral center, focusing on perinatal characteristics and the impact of first the metabolic crisis on long-term outcome.

Methods

Perinatal features, clinical and laboratory characteristics on admission and follow-up of 108 neonates diagnosed with OAs were retrospectively analyzed. Global developmental delay, abnormal electroencephalogram (EEG) or brain magnetic resonance imaging (MRI), chronic complications, and overall mortality. Associations between clinical findings on admission and outcome measures were evaluated.

Results

Most prevalent OA was maple syrup urine disease (MSUD) (34.3%). Neonates with methylmalonic acidemia (MMA) had significantly lower birth weight (p<0.001). Metabolic acidosis with increased anion gap was more frequent in MMA and propionic acidemia (PA) (p=0.003). 89.1% of OAs were admitted for recurrent metabolic crisis. 46% had chronic non-neurologic complications; 19.3% of MMA had chronic kidney disease. Abnormal findings were present in 26/34 of EEG, 19/29 of MRI studies, and 32/33 of developmental screening tests. Metabolic acidosis on admission was associated with increased incidence of abnormal EEG (p=0.005) and overall mortality (p<0.001). Severe hyperammonemia in MMA was associated with overall mortality (33.3%) (p=0.047). Patients diagnosed between 2007–2017 had lower overall mortality compared to earlier years (p<0.001).

Conclusions

Metabolic acidosis and hyperammonemia are emerging predictors of poor outcome and mortality. Based on a large number of infants from a single center, survival in neonatal-onset OA has increased over the course of 30 years, but long-term complications and neurodevelopmental results remain similar. While prompt onset of more effective treatment may improve survival, newer treatment modalities are urgently needed for prevention and treatment of chronic complications.
(Im)politeness as a tool to categorize interactive discourse markers of Arabic in radio shows
Authors: Jarrah Marwan , Alghazo Sharif , Asad Arwa
Published: October 2022

Little research has related DMs to (im)politeness, and none in Jordanian Arabic (JA). This study provides evidence that (im)politeness can categorize interactive DMs into polite DMs and impolite DMs in JA. It aims to explore the use of DMs in JA in relation to (im)politeness dichotomy. Twenty-two episodes of three different Jordanian radio shows which use vernacular JA were recorded and transcribed. With the help of prosodic cues and native speakers’ judgement and comprehension of the relevant utterances, this study finds that DMs can be categorized into polite DMs and impolite DMs. For instance,ʕafwanعفوا ‘excuse me’ andja:si:di: يا سيدي ‘sir’ are exclusively used as mitigating polite DMs whilstwbaʕdi:n maʕakوبعدين معك ‘hey stop!’ andeṯlaʕ min ra:si:اطلع من راسي ‘get out of my head’ are impolite DMs which are primarily used in complaints and expressions of state of anger. This is all interpreted as evidence that interactive DMs can be strongly flavored by politeness which regulates their distribution and manifestation. The study contributes to research on DMs by presenting a categorization based on (im)politeness and thus strengthening the link between discourse and pragmatics.
Konjunkturzyklen in Deutschland – die Datierung durch den Sachverständigenrat
Authors: Breuer Sebastian , Elstner Steffen , Kirsch Florian , Wieland Volker
Published: October 2022

In diesem Papier stellen Sebastian Breuer, Steffen Elstner, Florian Kirsch und Volker Wieland, ehemaliges Mitglied des Sachverständigenrates zur Begutachtung der gesamtwirtschaftlichen Entwicklung (SVR), die Konjunkturdatierung des Sachverständigenrates vor. Die Autoren arbeiten stilisierte Fakten für die sich ergebenden Zyklen heraus und präsentieren Besonderheiten der Rezessionsphasen. Methodisch orientiert sich die Datierung an den Verfahren des National Bureau of Economic Research (NBER) und des Centre for Economic Policy Research (CEPR). Eine Rezession wird als signifikanter Rückgang der gesamtwirtschaftlichen Aktivität definiert, der sich in weiten Teilen der Wirtschaft zeigt. Der Sachverständigenrat hat für Deutschland sechs Rezessions- und sieben Aufschwungphasen seit 1950 identifiziert. Der jüngste konjunkturelle Hochpunkt wird auf das vierte Quartal 2019 beziehungsweise Februar 2020 datiert. Die darauffolgende Corona-Rezession ist die siebte Nachkriegsrezession. Eine Datierung des konjunkturellen Tiefpunktes steht noch aus.
A singular case of hyposmia and transient audiovestibular post-vaccine disorders: case report and literature review
Authors: Fantin Francesco , Frosolini Andrea , Tundo Isabella , Inches Ingrid , Fabbris Cristoforo , Spinato Giacomo , de Filippis Cosimo
Published: October 2022

Introduction

Rare and mild adverse effects on cranial nerves have been reported after vaccination. Here, we report a singular case of smell and taste disorder associated with tinnitus that occurred after Oxford-AstraZeneca vaccination together with a review of the available literature.

Case presentation

A 76-year-old patient experienced smell disorder, ear fullness and tinnitus 2 days after the first dose of Oxford-AstraZeneca vaccine. The patient then underwent a complete audiological and Ear, Nose and Throat evaluation, nasal endoscopy, Sniffin’Sticks battery, audiometric test battery, and cerebral magnetic resonance imaging (MRI). The exams revealed hyposmia and bilateral reduction of the volume of the olfactory bulbs (OB). At the follow-up, tinnitus was completely resolved while olfactory dysfunction only partially reduced.

Review of the literature

A PubMed search was conducted on olfactory and gustatory dysfunctions after COVID-19 vaccination resulting in four case reports with a total of 10 patients. The main symptoms were hyposmia, parosmia, and dysgeusia developed after 1–9 days from vaccination with complete resolution occurring within 1 month. Notably, none of the considered articles reported reduction of OB volumes at cerebral MRI.

Discussion

So far, no definitive cause–effect relationship has been established between anti-COVID19 vaccination and otolaryngologic adverse reactions. The persistence of hyposmia in our patient could possibly be explained by the reduction in OB volume, even though also the advanced age of the patient needs to be taken into account. This is a first indication of a cause–effect relation between hyposmia and Covid19 vaccination, even though a more robust study is needed to confirm the autoimmunological mechanisms responsible for these rare adverse reactions. However, it is worth highlighting that benefits of the anti-COVID-19 vaccination clearly outweigh the risk of rare adverse events.
Household salt production by the Late Classic Maya: underwater excavations at Ta'ab Nuk Na
Authors: McKillop Heather , Sills E. Cory
Published: October 2022

Salt is an essential commodity; archaeological remains around the world attest to the importance of its production, exchange and consumption. Often located in coastal locations, many production sites were submerged by rising seas, including the Paynes Creek Salt Works on the southern Belize coast. Survey and excavation of these sites has identified ‘kitchens’ for brine boiling, as well as Terminal Classic residential structures at Ek Way Nal. The authors report the discovery of an earlier residential building alongside salt kitchens at the nearby site of Ta'ab Nuk Na. This finding indicates that surplus household production began during the Late Classic, when demand for salt from inland cities was at its peak.
Corticotroph tumor progression speed after adrenalectomy
Authors: Bessiène Laura , Moutel Sandrine , Lataud Marine , Jouinot Anne , Bonnet-Serrano Fidéline , Guibourdenche Jean , Villa Chiara , Baussart Bertrand , Gaillard Stephan , Barat Maxime , Dohan Anthony , Bertagna Xavier , Dousset Bertrand , Bertherat Jérôme , Assié Guillaume
Published: October 2022

Objectives

After bilateral adrenalectomy in Cushing's disease, corticotroph tumor progression occurs in one-third to half of patients. However, progression speed is variable, ranging from slow to rapid. The aim was to explore corticotroph progression speed, its consequences and its risk factors.

Design

A retrospective single-center observational study.

Methods

In total,103 patients with Cushing's disease who underwent bilateral adrenalectomy between 1990 and 2020 were included. Clinical, biological, histological and MRI features were collected. Median duration of follow-up after bilateral adrenalectomy was 9.31 years.

Results

In total,44 patients progressed (43%). Corticotroph tumor progression speed ranged from 1 to 40.7 mm per year. Progression speed was not different before and after bilateral adrenalectomy (P  = 0.29). In univariate analyses, predictive factors for rapid corticotroph tumor progression included the severity of Cushing's disease before adrenalectomy as the cause of adrenalectomy, high ACTH in the year following adrenalectomy and high Ki67 immunopositivity in the tumor. During follow-up, early morning ACTH absolute variation was associated with corticotroph tumor progression speed (P-value = 0.001). ACTH measurement after dynamic testing did not improve this association.

Conclusion

After adrenalectomy, corticotroph progression speed is highly variable and manageable with MRI and ACTH surveillance. Progression speed does not seem related to bilateral adrenalectomy but rather to intrinsic properties of highly proliferative and secreting tumors.
Identifying metastatic renal cell carcinoma in thyroid fine-needle aspirates by molecular testing
Authors: Freeman Tanner , Taneja Charit , Ohori N Paul , Wald Abigail I , Skaugen John , Yip Linwah , Kim Seungwon , Ferris Robert L , Nikiforova Marina N , Roy Somak , Nikiforov Yuri E
Published: October 2022

Renal cell carcinoma (RCC) is the most common type of cancer found to metastasize to the thyroid gland. These tumors may represent a diagnostic challenge in cytology. However, most RCC tumors carry VHL alterations, which are rare in primary thyroid tumors. The aim of this study was to evaluate the utility of molecular testing in detecting metastatic RCC in thyroid fine-needle aspiration (FNA) samples. From November 2017 until March 2022, thyroid FNA samples with ThyroSeq v3 results showing both VHL alterations and low/absent expression of thyroid cell markers were analyzed. Eighteen samples from 15 patients met the inclusion criteria. On molecular analysis, deleterious VHL mutations were found in nine (50%) nodules, VHL copy number alteration (CNA) in two (11%), and both mutations and CNA in seven (39%). None of the cases showed mutations commonly found in thyroid tumors. The mean age of these patients was 68 (range, 49–89) years with a male to female ratio of 2:1. Eight (53%) patients had multiple thyroid nodules on ultrasound. On cytology, 14 (78%) nodules were diagnosed as Bethesda III, 2 (11%) as Bethesda IV, and 2 (11%) as Bethesda V. At the time of cytology review, the history of RCC, sometimes remote, was available for ten patients. Of the 14 patients with medical history or surgical follow-up available, all had history of RCC or renal mass or revealed metastatic RCC on thyroidectomy. This study demonstrates that molecular testing can reliably identify metastatic RCC in thyroid nodules with indeterminate cytology, which could improve patient management.
Water-jet assisted nanosecond laser microcutting of northeast China ash wood: Experimental study
Authors: Yang Chunmei , Jiang Ting , Yu Yueqiang , Bai Yan , Song Mingliang , Miao Qian , Ma Yan , Liu Jiuqing
Published: October 2022

Laser machining is an advanced technology that provides efficiency and precision for the processing of wood. In this paper, the ablation mechanism of wood processed via a water-jet assisted nanosecond laser was analyzed. The influences of cutting speed and laser power on the cutting width of northeast China ash wood (NCAW) (Fraxinus mandshurica Rupr.) with and without the water-jet assisted system were evaluated. The surface morphology of the kerf of processed NCAW was observed via scanning electron microscopy (SEM). Furthermore, a factorial design experiment was carried out to analyze the effects of process parameters on the cutting width. Additionally, the experimental results were processed by multilinear regression analysis. The results showed that with the water-jet assisted system, the minimum value of the cutting width was 0.18 mm when the cutting speed was 50 mm/s and the laser power was 6 W, and good surface quality was obtained. The experimental results were processed by an analysis of variance and multilinear regression analysis. The predicted model, effectively validated by the experiments, had good prediction accuracy, which provided a theoretical basis for predicting the cutting width of NCAW processed by a water-jet assisted laser.
Time of exposure at 60 °C service temperature: Influence on strength and modulus of elasticity in compression parallel to the grain of hardwood species
Authors: Almeida Tiago H. , Almeida Diego H. , Arroyo Felipe N. , De Araujo Victor A. , Chahud Eduardo , Branco Luiz A. M. N. , Pinheiro Roberto V. , Christoforo André L. , Lahr Francisco A. R.
Published: October 2022

The aim of this research was to determine the influence of exposure time at 60 °C in the compression strength parallel to the grain (fc0) and modulus of elasticity in compression parallel to the grain (Ec0) for cupiúba (Goupia glabra), eucalypt (Eucalyptus saligna), garapeira (Apuleia leiocarpa) and jatobá tamarindo (Hymeneae sp.) wood species. The factor investigated in this research was the residence time in kiln (exposure at controlled temperature 60 °C) of specimens: 0 (wood tested at room temperature and moisture content around to 12%), 168, 456, 720, and 2160 hours, simulating the reaction of the material in confined roof structures. Compression parallel to the grain tests were conducted according to the methods of the Brazilian Standard Code ABNT NBR 7190 (1997). ANOVA results indicated that the temperature (60 °C) had a significant influence in the five exposure times. All studied wood species showed an increase in the fc0 value with increasing time of exposure at 60 °C. For Ec0, this phenomenon occurred only for the jatobá tamarindo and cupiúba wood species.
On the Ontology of Law and the Oblivion of Being
Authors: Šerpytytė Rita
Published: October 2022

This article hypothetically puts forth the idea of the ontology of Law as the “First Philosophy”. The presentation and justification of this idea is linked with the rethinking of the approach to examining law. This approach seeks to investigate law neither as the object of jurisprudence, legal theory, nor even, and this is especially crucial, legal philosophy; it rather consists in justifying the possibility of looking at the law from an ontological philosophical perspective, revealing the fundamental link between law and being. In contrast, by treating law as a given and not raising the question of its emergence as such, by searching for “right” laws “in accordance with nature”, even when ontological terms are being used, the ontological context of law’s emergence is not revealed; rather, only ontological pretentions to existing laws are asserted. This article discusses the work of the Ancient philosophy scholar Werner Jaeger, which allows one to rethink the idea of the ontology of law and to outline the direction for “resetting” the notion of law.
The Return of Religion and the Problem of Radical Evil: A Case Study of Russia’s War in Ukraine
Authors: Bacevičiūtė Danutė
Published: October 2022

The article analyses the case of Russia’s war in Ukraine by focusing on the ambivalent relationship between radical evil and the “return of the religious”. First, the revival of politicised religious fundamentalism in contemporary Russia is examined by discussing the relationship between the state and the church and its concretisation in the field of foreign policy – the “Russian World” teaching. The article shows how the Russian Orthodox Church legitimises a project that pursues geopolitical goals and justifies the started war as a metaphysical fight against evil. Attention is drawn to the fact that in this case we are dealing with a kind of “secular religion” or “inverted secularism”, when ecclesial forms are used to revive the Soviet imperialism, and faith is replaced by beliefs. Next, when considering the analysed case in the context of the “return of the religious” reflected by Jacques Derrida and Gianni Vattimo, the emphasis is not only on the principle of violence (which is born from the fusion of political and religious discourses), but also on the positive possibilities of this return, which aforementioned thinkers elaborated by formulating the concepts of elementary faith and ethics of charity. At the same time, the article shows that these concepts lack an existential focus that would allow the problem of radical evil to be grasped at the level of individual existence. Therefore, to highlight the existential aspect of radical evil, the concepts of the perverse will, “grey zone” and impossible hope are used.
The Rhetorical Impact of Polylingualism Employed by Lithuanian Politicians on Facebook
Authors: Gabrėnaitė Eglė , Biržietienė Skirmantė
Published: October 2022

The aim of the research presented in this article aims to determine the impact of polylingualism on the effectiveness of political rhetoric in Lithuania. The study focuses on elements borrowed from other languages and used by Lithuanian politicians in their Facebook posts. In addition, the motivation behind such use is explored, aiming to establish whether polylingualism is part of a conscious effort of political communication in order to build a positive image. Within the scope of this research are Facebook posts containing cases of polylingualism, specifically, English-language inserts. The authors of these posts are prominent politicians who are native Lithuanian speakers engaged in active communication on social media. Collected during the period of 2018–2021, the research material was examined using the method of rhetorical discourse analysis, resulting in the identification of characteristic instruments of persuasion, i.e. the tools which help enhance the effectiveness of certain discourse. The researchers aimed to determine the general patterns and dominant tendencies of mixed speech within the political discourse on social media. The research reveals the use of polylingualism as a stylistic tool imitating informal speaking and creating contextual discourse.
The Persuasive Function of the Title as a “Movere” Tool in Journalistic Film Reviews
Authors: Topa-Bryniarska Dominika
Published: October 2022

Based on theories in pragmatics, rhetoric, argumentation and discourse analysis, the genre of “journalistic film review”, relatively little examined, has been analysed in this paper as a discourse reflecting a justified assessment. Our analysis, presented as a case study, concerns the persuasive function of the titles of 53 French and francophone film reviews. In this analysis, the act of persuasion, anchored in Perelman’s (1971) concept of argumentation, corresponds to the rhetorical structure of public discourse. For the act of persuasion, we focus on discursive and stylistic parameters related to the rhetorical principle of “movere” as the basis of the film review’s deliberative (advisory and justifying) dimension. The role of this dimension is to invite the addressee to co-create the meaning of the discourse through the process of co-schematisation, implemented with the help of emotional argumentation in the form of appraisive and affective lexemes. These stylistic devices also constitute a mechanism of persuasion typical of advertising discourse.
Mutation of Dystopian Identity in the Age of Posthumanism: Literary Speculations
Authors: Bezrukov Andrii , Bohovyk Oksana
Published: October 2022

Dystopia while deconstructing utopian ideas generates a special type of identity as a consequence of a deviation from anthropocentric principles, crises of national and cultural worldviews, and changes in manifestations of social shifting in the posthumanist world. The article has focused on four symptomatic dystopian texts – George Orwell’s Nineteen Forty-Eight, Ray Bradbury’s Fahrenheit 451, Ahmed K. Towfik’s Utopia, and Salman Rushdie’s Quichotte – to explicate the dichotomous nature of the opposition of identity vs society in the posthumanist transformations. Those conditions are considered a cause of the mutation of dystopian identity that troubles its anthropological bases and modes of existence. To reconstruct the posthumanist context and its influence on the dystopian identities in the selected novels, this study has exploited a mixture of the following methods: intertextual, cultural, and genre ones; phenomenological approach; hermeneutic interpretation; conceptualisation, etc. The novelty of the study emanates from the very attempt to interpret the writers’ names of the AGEs which are represented in the books as a background of storytelling and a lens through which the posthumanist space is transformed from a dystopian perspective.
Emily Dickinson in the Work of Polish Translators. Continuation of Research
Authors: Krzysztofik Małgorzata , Wzorek Anna
Published: October 2022

This article deals with the Polish translation of Emily Dickinson’s poetry and correspondence. It is a continuation of the reflection in The Emily Dickinson Journal’s pages, which started in 2022. This time we present translations of Kazimiera Iłłakowiczówna, Andrzej Szuba, Krystyna Lenkowska, Ryszard Mierzejewski, Tadeusz Sławek, Teresa Pelka, Artur Międzyrzecki, Lilla Latus, Agnieszka Osiecka, Agnieszka Kreczmar and Ewa Kuryluk. We discuss a selection of Dickinson’s letters translated by Danuta Piestrzyńska. We emphasize the characteristic features of each of the discussed translations. Although Iłłakowiczówna discovered Dickinson for Polish readers, her translations are perceived as archaic. Szuba mainly translates aphoristic texts. Lenkowska makes an effort to be faithful to the original. The newest translators introduce Poles to unknown poems and make new translations of the texts previously rendered into Polish.
CFD study to optimize the auxiliary ventilation system in an underground mine
Authors: Vives Jordi , Bascompta Massanés Marc , De Felipe José Juan , Sanmiquel Lluís
Published: October 2022

Four different scenarios have been studied in an underground mine, validating the results by actual data. Finding the best ventilation conditions in terms of air velocity and heat load removal. The conditions worsen as the duct is placed further from the face. While the position of the duct regarding cross-section, lower or upper side of the drift, does not give a clear conclusion about the best option, but it depends on the variable used in the analysis, either temperature, air velocity or the specific area in the working face. The findings of this study can be used to implement the most efficient auxiliary ventilation system in the mine considering the potential main issue, whether it is the working face or the place of the equipment. Besides, future scenarios can be also analysed with the model created, providing a good tool to select the auxiliary ventilation layout in each case.
Complete-Linkage Clustering Analysis of Surrogate Measures for Road Safety Assessment in Roundabouts
Authors: Bulla Cruz Lenin Alexander , Lyons Liliana , Darghan Enrique
Published: October 2022

This paper presents the findings of a comparative road safety assessment between an existing two-lane roundabout and proposed basic turboroundabout, both designed for the same intersection, to determine which one is safer, based on traffic conflicts and surrogate safety measures. We performed microsimulation models in VISSIM to replicate the fieldobserved traffic operation, and the SSAM to determinate six surrogate measures. We validated the consistency of values obtained by several statistical analyzes. The number of conflicts was 72% lower at the turboroundabout. Through a complete-linkage clustering analysis and Euclidean distances of the surrogate measures, we found that traffic conflicts at the turbo-roundabout tend to cluster in a group, whereas conflicts at the roundabout are scattered, suggesting better organization of traffic flows at the turbo-roundabout. Three-dimensional graphical analysis of clusters and its centroids allowed verifying that surrogate measures point out a safer operation at the turbo-roundabout, even though it presented higher operating speeds. Reducing the dimensionality by principal components analysis, the cumulative variance for the first two components (87.72%) allowed observing results on a two-dimensional graph and their clusters. To endorse conflicts classification, resulting of clusters, we used discriminant analysis. Results validate the methodology and the safety benefits of the turbo-roundabout.
On Some Statistical Properties of the Spatio-Temporal Product Density
Authors: Rodríguez Berrio Juan F. , Rodríguez-Cortes Francisco J. , Mateu Jorge , Adelfio Giada
Published: October 2022

We present an extension of the non-parametric edge-corrected Ohser-type kernel estimator for the spatio-temporal product density function. We derive the mean and variance of the estimator and give a closed-form approximation for a spatio-temporal Poisson point process. Asymptotic properties of this second-order characteristic are derived, using an approach based on martingale theory. Taking advantage of the convergence to normality, conﬁdence surfaces under the homogeneous Poisson process are built. A simulation study is presented to compare our approximation for the variance with Monte Carlo estimated values. Finally, we apply the resulting estimator and its properties to analyse the spatio-temporal distribution of the invasive meningococcal disease in the Rhineland Regional Council in Germany.
Wavelet Shrinkage Generalized Bayes Estimation for Multivariate Normal Distribution Mean Vectors with unknown Covariance Matrix under Balanced-LINEX Loss
Authors: Afshari Mahmoud , Karamikabira Hamid
Published: October 2022

In this paper, the generalized Bayes estimator of mean vector parameter for multivariate normal distribution with Unknown mean vector and covariance matrix is considered. This estimation is performed under the balanced-LINEX error loss function. The generalized Bayes estimator by using wavelet transformation is investigated. We also prove admissibility and minimaxity of shrinkage estimator and we present the simulation study and real data set for test validity of new estimator.
Extended Lindley Distribution with Applications
Authors: Chhetri Sher , Mdziniso Nonhle , Ball Cory
Published: October 2022

In this work, we propose a three-parameter generalized Lindley distribution using the cubic rank transmutation map approach by Granzotto, Louzada & Balakrishnan (2017). We derive expressions for several mathematical properties including moments and moment generating function, mean deviation, probability weighted moments, quantile function, reliability analysis, and order statistics. We conducted a simulation study to assess the performance of the maximum likelihood estimation procedure for estimating model parameters. The flexibility of the proposed model is illustrated by analyzing two real data sets.
Causal Mediation for Survival Data: A Unifying Approach via GLM
Authors: Taddeo Marcelo M. , Amorim Leila D.
Published: October 2022

Mediation analysis has been receiving much attention from the scientific community in the last years, mainly due to its ability to disentangle causal pathways from exposures to outcomes. Particularly, causal mediation analysis for time-to-event outcomes has been widely discussed using accelerated failures times, Cox and Aalen models, with continuous or binary mediator. We derive general expressions for the Natural Direct Effect and Natural Indirect Effect for the time-to-event outcome when the mediator is modeled using generalized linear models, which includes existing procedures as particular cases. We also define a responsiveness measure to assess the variations in continuous exposures in the presence of  ediation. We consider a community-based prospective cohort study that investigates the mediation of hepatitis B in the relationship between hepatitis C and liver cancer. We fit different models as well as distinct distributions and link functions associated to the mediator. We also notice that estimation of NDE and NIE using different models leads to non-contradictory conclusions despite their effect scales. The survival models provide a compelling framework that is appropriate to answer many research questions involving causal mediation analysis. The extensions through GLMs for the mediator may encompassa broad field of medical research, allowing the often necessary control for confounding.
Replik und Revision: Standards für Design-Based Research
Authors: Reinmann Gabi
Published: October 2022

Die Entwicklung von Standards für Design-Based Research (DBR) ist ein Desiderat. Mit meinem Beitrag „Was macht Design-Based Research zu Forschung? Die Debatte um Standards und die vernachlässigte Rolle des Designs“ habe ich zwölf Standards auf den Ebenen Wissenschaftlichkeit und Designangemessenheit erarbeitet und zur Diskussion gestellt. Drei DBR-Experten haben die Einladung zum Austausch angenommen und Diskussionsbeiträge verfasst, die wichtige Impulse für eine Revision der vorgeschlagenen Standards gegeben haben. Der vorliegende Beitrag ist sowohl eine Replik auf die kritische Auseinandersetzung mit meinem Text als auch der Entwurf für eine neue Herangehensweise an die Standardentwicklung für DBR. Diese basierte auf einem entwurfstheoretischen Modell aus den Designwissenschaften und rückt das Design als Erkenntnismodus konsequent in den Mittelpunkt.
CTA #2. Accelerated Curing
Authors:   Concrete Technology Associates
Published: October 2022

Data and recommendations for steam and dry heat curing are presented. Also discusses the steam injection method of producing hot concrete, optimized procedures, quality control and cylinder testing.
CTA #7. Non-Destructive Testing of Concrete
Authors:   Concrete Technology Associates
Published: October 2022

Describes applications of non-destructive testing devices including Schmidt hammer, Windsorprobe, and ultrasonic probe velocity equipment. Describes how to use this equipment and how to record and interpret the results. Also discusses advantages and shortcomings. The supplement shows how to use the Schmidt hammer to estimate the compressive strength of dry cast products.
CTA #12. Low Relaxation Strand
Authors:   Concrete Technology Associates
Published: October 2022

Describes the characteristics of low relaxation strand and discusses ways in which it may be used to advantage. Deals with the engineering and design aspects of low relaxation strand, particularly as related to code requirements. Provides illustrative design examples that translate into materials and manufacturing cost savings.
CTA #15. Prestressed Concrete Pile Splicing
Authors:   Concrete Technology Associates
Published: October 2022

Covers logic, advantages, service requirements, and design criteria of pile splices. Discusses test results of the Anderson Pile Splice.
Political scandals, media systems, and ideological polarization: the case of the emeritus King Juan Carlos I
Authors: Ortiz-González Azahara , Berganza Rosa
Published: October 2022

Research on scandals is a privileged way to explore jointly media and political systems, and the links between them. In this article, we explore how the coverage of political corruption in digital native and paper newspapers has the characteristics of politically oriented scandals (Mancini, 2019), which are more common in polarized pluralist systems, like the Spanish one. To do so, we have studied the scandals related to the former King of Spain, Juan Carlos I. In the research, we have analyzed the evolution of media coverage on the topic between July 1, 2014, and March 1, 2021 in three different paper newspapers (El País, El Mundo and ABC). During this period, 889 journalistic pieces were published in these three newspapers. Also, we have conducted a quantitative and qualitative analysis of a sample of 334 pieces from the last year covered by the research (2020-2021) on El País, El Mundo and ABC and on digital natives El Español and elDiario.es. The results show a political instrumentalization of the scandal, media partisanship (the media support some political parties’ positions) in El País, elDiario.es and ABC; and ideological polarization (analyzed content presents two politically opposed groups) in ABC and elDiario.es.
Telegram in campaign: the use of mobile instant messaging services in electoral political communication
Authors: Alonso-Muñoz Laura , Tirado-García Alejandra , Casero-Ripollés Andreu
Published: October 2022

The use of mobile instant messaging platforms has increased in recent years in political communication given the private nature of this form of communication, a trend which has increased during the COVID-19 pandemic. The aim of this research is to know the Telegram usage done by the main political parties within the election campaign. For this purpose, the Catalan election of the 14th of February 2021 are studied with a quantitative content analysis on a sample composed of 600 messages published by five political parties (PSC, Vox Barcelona, ERC, Junts per Catalunya, CUP and En Comú Podem). Results show that one of the most important functions of this platforms is the information and dissemination of its electoral programme. Regarding the main topics, the organization and functioning of the campaign and the political wrangling predominate. Our findings show that the position of the different parties regarding the independence of Catalonia, their political trajectory and their position within the government/opposition axis are conditioning factors of their communication strategy on this platform. Finally, the analysis of the public impact of the published messages reveals the disconnection between the parties and the citizens. In addition, a “more is more” effect which determines that the more messages are broadcast on this platform, the greater the number of views by users is, is detected. These data reveal new evidence on how Telegram is being used in the election campaign by political actors.
Tu scis regem sedere (Kilvington, S47 [48])
Authors: D'Ors Ángel
Published: October 2022

This work examines Richard Kilvington's Sophisma 47, in the context of the Doctrine of Obligations. Its aim is to revise the thesis of P. V. Spade, who attributes to Kilvington an intermediate position between Burley and Swyneshed, and interprets the Doctrine of Obligations in general as a Theory of Counterfactuals.
Estudios jurídicos sobre el papel de la mujer en la Baja Edad Media
Authors: Galán Mercedes
Published: October 2022

The most documented juridical studies about hispanic woman in the late Middle Ages, belong to three specialities: political law, civil or common law (matrimonial), and criminal law. It is in the sphere of matrimonial law where the influence of christian principles has been described as prominent, contributing to the juridical conjugal parity, thus recognizing woman a full civil capability.
Sociedad y Bienestar. El concepto de bienestar
Authors: Morales Julián
Published: October 2022

This article tries to go deeply into the very concept of the well-being, from which the author attempts to justify what is called the "crisis" of the society or the "crisis" of the Welfare State.
Libertad trascendental y educación. Sobre el modelado en educación
Authors: Barrio José María
Published: October 2022

The "transcendental freedom" is proper of the personal being, free and intelligent. This key concept of Heidegger ("transzendentalen Freiheit") is reelaborated by Millán-Puelles with Thomas Aquinas' contributions, mainly Aquinas' theory on the properties of transcendental being ("ens transcendentale"). This reelaboration is relevant for the discussion about the importance of educational paradigms. A human person is something "open" to the being and value and consequently, to educate is to communicate values through personal paradigms.
Peirce y la ciencia cognitiva
Authors: Gomila Antoni
Published: October 2022

In this paper I try to establish the relevance of Peirce's Semeiotics to the conceptual foundations of Cognitive Science. Given Cognitive Science's commitment to the Representational Theory of Mind, I try to clarify the nature of mental representation from the standpoint of Peirce's general theory of signs. As it turns out, mental representations, because of their special role as interpretants of non-mental signs, present especial problems for their interpretation, whose solution Peirce anticipated in a way very close to that developed in Cognitive Science.
«Cogito ergo sum» como conculcación al axioma A
Authors: Merino Magdalena
Published: October 2022

The purpose of this work is to explain how, with the proposition «cogito ergo sum», Descartes contradicts the A axiom from the Theory of knowledge of Leonardo Polo, by accepting the pasivenness of the knowledge and denying it as an operation of knowing an object, in which the cognizant and the cognizance are one in act.
Descartes: un nuevo modo de hacer filosofía
Authors: Corazón Rafael
Published: October 2022

The interpretation of Descartes’ thinking wich is made by professor Polo in Evidencia y realidad en Descartes (and, in general, in all his work) is analysed in this article . The key to understanding Descartes is “the voluntary attitude”, which lies in placing the attention before the arrival of facts and contents of consciousness. So they can be examined and controlled in order to decide if they are reliable or not. The result is an exaggerated dedication which limits the capacity of intelligence to act according to its nature.
Esbozo de una filosofía trascendental. Introducción
Authors: Falgueras Ignacio
Published: October 2022

I mind by transcendental philosophy the pure inquiry of the ultimate realities also called transcendental realities. The whole inquiry is divided in two parts. The first one is dedicated to study the inconditional transcendentals, and the second one to study the conditional transcendentals. Both parts are preceded by one introduction, whose content constitutes the present paper.
Sobre el ser y la creación
Authors: García Juan
Published: October 2022

This paper deals with Leonardo Polo’s philosophy about the subject of creation. The “abandonment of mental limit” permit us to aware of the real distinction essentia-esse (essence-being). That is important in order to think over universe and human being as created.
Los primeros principios: interpretación de Polo de Aristóteles
Authors: Morán Jorge
Published: October 2022

The author studies the theory of "first principles" at Leonardo Polo's philosophy (at the book El conocimiento habitual de los primeros principios) and Aristotle thought. He critics Polo's theory of first principles in using aristotelian concepts from Metafísica, III, IV and IX.
El sentido de los trascendentales
Authors: De Garay Jesús
Published: October 2022

This paper wants to elucidate the meaning of “order of transcendentals”. That matter has a preferential place in L. Polo’s philosophy. This study is carried out through an analysis of concept of “meaning” and specially “the meaning of being”.
¿Es la naturaleza un libro escrito en caracteres matemáticos?
Authors: Arana Juan
Published: October 2022

Throughout the centuries, the studious of the nature have verified time and time again the effectiveness of the mathematics to formalize the knowledge of the world. To what extent it is thus, and why reason, they are enigmas that still wait for answer. Some theoretical alternatives are explored to catch the diverse dimensions of this subject.
Acerca del platonismo y de Platón mismo
Authors: Rodríguez Pablo
Published: October 2022

The article criticises Reale's esoteric interpretation of Plato from a hermeneutical point of view. Reale speaks of doctrines, written and unwritten, where we only have two traditions: direct and indirect. Plato's own works build a corpus and a collection of testimonies from different authors cannot be considered as interpretatively superior. To be written down is essential to interpretation and the text cannot be fixed on a concrete reading, because textuality means openness to new understandings. In this way, the attempt to reread Plato's dialogs in the light of this indirect tradition is to reduce the Platonic corpus to a mere pretext.
La propiedad en los "Tópicos" de Aristóteles
Authors: Reinhardt Tobias
Published: October 2022

Aristotle seems to have set up his logic of the with reference to the linguistic habit, i.e., the superficial impression that predications are defined in the Topics with reference to their logical form alone is false. It can be shown that Aristotle had become aware of this in the Prior Analytics and that he had adjusted his definition of the  to this. The article ends with some tentative remarks as to how these insights could shed new light on the system of predicables as a whole.
Dietrich von Hildebrand: semblanza biográfica
Authors: Stein Guido
Published: October 2022

Alice von Hildebrand has written an appealing philosophical biography of his husband. The Soul of a Lion delivers an accurate alibi for going deeper in Hildebrand's Weltanschauung, what is a philosophical theory of things themselves and a personal attitude as well.
Individual-tree-selection in uneven-sized Norway spruce stands in southern Sweden: Developments of tools for simulation and optimization
Authors:   ,   Linnaeus University, Faculty of Technology, Department of Forestry and Wood Technology, Fagerberg Nils
Published: October 2022

Individual-tree-selection (ITS) is a continuous cover forestry method thataims to utilize the uneven-sized stand structure through optimized individualtree selections. ITS is an interesting management alternative to rotationforestry in terms of production of multiple benefits and forest ownerprofitability. With regard to Fennoscandia, ITS is currently only practiced to alimited extent, partly because of a scarcity in knowledge and skills among allstakeholders, but also due to the shortage of scientific guidelines for howoptimized tree selections are performed in practice. Thus, the aim of thethesis is to develop tools for optimizing practical ITS recommendations forNorway spruce.Tree position data for model fitting were collected from five trial sites insouthern Sweden, one of which was documented with terrestrial laser scanningto get crown shape data for knot size modelling. A method that optimizes thetarget diameter dependent on the discount rate and the degree of thelocal competition exposed to the subject tree, was developed. Technically, adefined adaptive control function was optimized with full system stochasticsimulation and with expected present value as the objective functionvariable. Since the quality of the optimization is dependent on the qualityof the models in the simulation, priority was given to the evaluation anddevelopment of the central models. Available individual tree growth modelswere tested and evaluated with tree data from long term uneven-sizedtrial plots. Furthermore, new individual-tree distance-dependent growthmodels were developed for uneven-sized Norway spruce. A modellingframework, for prediction of the largest knot size per stem height section,was developed to provide means of simulating log quality depending on theimpact from local tree competitors.The results indicated that the thinning intensity in uneven-sized standstructures may be used to actively control the transition point where smallerdiameter classes are subjected to suppressed growth. The evaluation ofthe Swedish individual-tree growth models which are included in theHEUREKA forest simulator, showed underestimation of large trees andoverestimation of small trees. The underestimation is smaller or absent indenser forests for diameter classes above 40 cm. The new distance-dependentgrowth models are presented in two versions, one with and one without crownratio as a predictor. The new growth models facilitate the testing of spatialdecision criteria in ITS optimization. From the results of the ITSoptimization, field operators can choose either a fixed level target diameteror a flexible target diameter that is adaptive to the degree of localcompetition surrounding the subject tree. Optimal fixed target diametersat breast height range from 33 cm to 23 cm depending on discount rate(1–3 %). A decision support structure for ITS is proposed.
Towards hermeneutics of substantial change. Between conciliar continuity and tendency to break
Authors: Napiórkowski Andrzej
Published: October 2022

In the interpretation of Revelation, as well as, documents of the Magisterium of the post-conciliar Catholic theology, strong tensions and differences have been exposed.They are a consequence of various hermeneutics. Each of the sides claims the right to define “a reform”.However, a careful and critical analysis of the three functioning types of hermeneutics (of absolute continuity, of a break, and of absolute fidelity to the tradition) is not fully satisfactory.In its external form of expression the symbols and dogmas of faith are historical, so with the flow of history they become anachronistic, despite the fact that the essence (the core) of the doctrine is not changed, because it comes from the Divine Revelation and is a subject of personal experience of the faithful. Therefore, a fundamental basis of faith lies in the event of Revelation, namely, the self-giving of the Triune God. Hence the Revelation must be understood not as a statement of truth, but as an event of truth. It is about personal experience of the Resurrected, and not just knowledge or information about Him. Therefore, the language and the manner of communication must be constantly verified and contemporized. While the truth is always not completely grasped. This is why the presented article is a small contribution in developing a fourth type of hermeneutics – a hermeneutics of substantial change, which though would allow to break the continuity at some points, nevertheless would not destroy the identity of faith.
The vision of a united Europe and Poland’s place and role in it in the light of St. John Paul II’s teaching
Authors: Borutka Tadeusz
Published: October 2022

The entire history of Europe and the awareness of a common identity formed in its course are clearly and deeply marked by Christianity and indicate a close relationship between the Church and Europe. Both in the West and in the East, the Church desires to contribute to the European Union. It feels responsible for the shape of the Old Continent and is convinced that it can also make an important contribution to the establishment of new institutional forms.In the age of pluralism and respect for all religious beliefs it is unacceptable that a tendency to discriminate against any religion should come to the fore. Since the European Union engages in dialogue with political parties, trade unions and representatives of various religions, it would be incomprehensible if the same attitude was not displayed towards Christianity.Above all, one must not ignore the transcendent dimension possessed by each human being. Indifference to this dimension may lead to tragic consequences and the European continent has seen plenty of those painful examples throughout its history. From the beginning of his pontificate, John Paul II expressed a great interest in European affairs. He showed Europeans a vision of unity in diversity, creative fidelity to Christian origins, in freedom, truth and solidarity.