bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantitative evaluation of a theoretical-conceptual model based on affective and socio-behavioral dimensions to explain the academic performance of mathematics students
Authors: Marín-Álvarez Felipe , Flores-Prado Luis , Figueroa Oriana , Polo Pablo , Varela Jorge J. , Muñoz-Reyes José Antonio
Published: August 2024

Objective

There is evidence that suggests that affective dimensions, personality traits, as well as students’ cooperative interpersonal interactions, are an important element in the students learning process. In this work we propose a theoretical model, based on evidence, that shows the direct and indirect relationships between these factors and academic performance in mathematics courses, in undergraduate and school students.

Methods

To understand the type of relationships between these variables, the PANAS psychometric test of positive and negative affect, the BIG FIVE personality test and the economic decision game DUPLES GAME were applied. The study sample was 130 students between 17 and 22 years of age from undergraduate and school (M ± SD = 20.1 ± 3.99).

Results

From a path analysis, statistically significant relationships were found, for example, a direct relationship between neuroticism and positive affect, which in turn is related to academic performance. We also found a direct relationship between neuroticism and negative affect, extraversion and positive affect. This allows us to propose that some of the independent variables of the model directly and indirectly influence the academic performance of students in the subject of mathematics.

Conclusion

Positive affect and negative affect directly affect academic performance in mathematics, neuroticism has a direct impact on negative affect and extraversion direct impact on positive affect. Consequently, there are direct and indirect relationships between personality traits and affective dimensions, which affect the academic performance of mathematics students.
Allowing time for 8+ hours of sleep: identification and validation of important beliefs using the reasoned action approach
Authors: Tagler Michael J.
Published: August 2024

Introduction

The present studies advance research using the Reasoned Action Approach to understand sleep behavior. Identification of the modal salient beliefs that individuals hold regarding their sleep habits is necessary to understand the attitudes, perceived normative pressure, and perceived behavioral control (PBC) that individuals hold.

Methods

Belief elicitation (Study 1) and follow-up validation (Study 2) studies of undergraduates at a Midwestern USA university were conducted to identify readily accessible and important beliefs regarding allowing time for 8+ hours of sleep each night.

Results

Important attitude relevant beliefs included positive effects on mood, thinking, health, and productivity. Important normative beliefs were perceived injunctive pressure from family, health professionals, and significant others. Because of the strong influence of PBC on intentions/behavior, most important were control beliefs about the need for good time management.

Discussion

The present studies increased our understanding why many individuals do not allow time to obtain adequate sleep. Identification of the beliefs that distinguish between those who intend to allow time for adequate sleep and those who do not is a necessary step toward the design of effective interventions to improve sleep duration. The results indicate that a focus on increasing time management skills and PBC may be an effective approach for sleep interventions.
The effect of ostracism on social withdrawal behavior: the mediating role of self-esteem and the moderating role of rejection sensitivity
Authors: Lei Yuju , Li Mingyue , Lin Chen , Zhang Chenshiyuan , Yu Zhen
Published: August 2024

Extant studies have empirically tested the main two behavior responses following ostracism: prosocial or antisocial. Few studies have investigated the relationship between ostracism and social withdrawal. According to the temporal need-threat model and the self-verification theory, the present study aimed to examine the influence mechanism of ostracism on social withdrawal, especially the mediating role of self-esteem and the moderating role of rejection sensitivity. A total of 1,315 Chinese high school students (52.6% female) completed a written questionnaire. Results showed that ostracism was positively correlated with social withdrawal. Ostracism not only directly predicted social withdrawal, but also indirectly affected social withdrawal by threatening adolescents’ self-esteem. High rejection sensitivity may help aggravate adolescents’ self-esteem threaten perceive from ostracism. Adolescents with high rejection sensitivity felt a greater threat to self-esteem when ostracized. Findings suggest a new direction for understanding individuals’ responses to ostracism.
Does the good life feel good? The role of positive emotion in competing conceptions of the good life
Authors: Novak Lukas , Kiknadze Nona
Published: August 2024

Flourishing refers to one kind of generalized wellbeing. Contemporary flourishing research often privileges positive emotion in the theorization and measurement of the construct, such that flourishing is frequently conceptualized as involving a predominance of positive over negative emotions. Positive emotions are thus, on some views of flourishing, seen as an essential component of “the good life.” This paper explores the nuanced variations in conceptions of the good life, focusing on the interplay between positive emotion and flourishing. Through an analysis of contemporary perspectives on flourishing, we underscore the diversity in conceptualizations of flourishing and the implications of this diversity for flourishing theorists. Our review reveals significant disparities in perspectives regarding the significance of positive emotion in the pursuit of a good life. Furthermore, we delineate the theoretical distinctions between objective-list approaches and functional approaches to flourishing, highlighting their respective advantages and limitations. Theoretical dissensus persists regarding whether positive emotion is a necessary constituent of the good life, thus prompting a critical examination of the justification for its inclusion in flourishing models. Finally, we emphasize the need for greater theoretical clarity in defining wellbeing to inform both research endeavors and societal discourse. We suggest that an adequate appreciation of variation in the development and maintenance of flourishing requires admitting for more complex relationships between the construct and both positive and negative emotionality, while embracing the cultural and individual variety that are unavoidable in accurate models of human life.
Mechanism of the impacts of older adults social participation on their health
Authors: Lin Sheng Ai , Xu Xueqing , Liu Yutong , Ai Bin
Published: August 2024

Purpose

Against the background of population aging challenges in China, focusing on health, security, and social participation as core elements of positive aging, this study aims to formulate strategies for promoting the health of the older adults and reveal the pathways and trends of social participation in promoting health.

Method

The study analyzed 1,015 randomly selected older adults individuals living at home in Beijing using household survey questionnaires. Drawing on group dynamics theory and structural equation modeling, the study proposed hypotheses regarding the relationships between social participation, group cohesion, and health status.

Results

First, the triangular path model of social participation, group cohesion, and health status among the older adults was established. The direct path coefficient of social participation on health status was 0.15, that of social participation on group cohesion was 0.56, and that of group cohesion on health status was 0.32. The indirect path coefficient of social participation on health status through group cohesion was calculated at 0.56 × 0.32 = 0.18. Second, of the older adults age groups—younger, middle, and older—social participation’s direct path effects on health status were present only in the older age group. Social participation’s indirect path effects on health status through group cohesion were relatively high in all three groups, with a slight increase in the older age group.

Conclusion

First, just the older adults participation in social activities serves as a benign stimulus to physical and mental health. Additionally, group cohesion formed through interaction with others during social activities encourages self-improvement behaviors, indirectly promoting health. In fact, indirect pathways of health promotion through group cohesion are stronger than direct pathways, highlighting the importance of group cohesion during social participation. Second, participation in activities alone can provide only sufficient benign stimuli for the older adults aged 80 and above, with the direct path effect of social participation on health beginning to appear only with increasing age. With age, selectivity of interaction with others decreases, and dependence increases; social participation’s indirect path effect on health through group cohesion continues to grow slightly.
Independent and joint associations between urinary polycyclic aromatic hydrocarbon metabolites and cognitive function in older adults in the United States
Authors: Lu Xin , Zhou Yanan , Miao Qingshan , Han Xuexue , Zhou Yi , Zhao Gaofeng , Yu Hao , Chen Min
Published: August 2024

Background

Polycyclic aromatic hydrocarbons (PAHs), as organic pollutants widely present in daily environments, have been shown by existing epidemiological studies to be significantly associated with deficits in learning and memory functions in children and adults. However, the association between exposure to PAHs and cognitive function in older adults remains unclear. Additionally, existing related studies have only assessed the association between individual PAH exposures and cognitive assessments, overlooking the risks posed by mixed exposures. This study aims to use three statistical models to investigate the individual and overall effects of mixed PAH exposures on the cognition of older adults in the United States.

Methods

The study cohort was obtained from the NHANES database, which included individuals aged 60 and older from 2011 to 2014. Weighted generalized linear models (GLM), weighted quantile sum (WQS) models, and Bayesian kernel machine regression (BKMR) models were utilized to evaluate the connections between urinary PAH metabolites and the standardized Z-scores of four cognitive tests: Immediate Recall Test (IRT), Delayed Recall Test (DRT), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST).

Results

Our analysis involved 899 individuals aged 60 and above. In the fully adjusted GLM, 2-hydroxynaphthalene (2-OHNa), 3-hydroxyfluorene (3-OHFlu), and 2-hydroxyfluorene (2-OHFlu) demonstrated negative associations with DSST Z-scores. In the WQS model, six urinary PAH metabolites were negatively linked to AFT Z-scores (β (95% confidence intervals [CI]): −0.120 (−0.208, −0.033), p = 0.007) and DSST Z-scores (β (95% CI): −0.182 (−0.262, −0.103), p < 0.001). In both assessments, 2-OHNa exerted the greatest influence among the urinary PAH metabolites. In the BKMR model, there was an overall negative correlation between urinary PAH metabolites and AFT and DSST Z-scores when the concentration was within the 25th to 75th percentile, where 2-OHNa dominated the main effect of the mixture. The WQS and BKMR models were adjusted for all covariates.

Conclusion

Increased concentrations of urinary PAH metabolites are associated with cognitive decline in older adults, mainly on language ability, executive function, sustained attention, working memory, and information processing speed, with 2-OHNa playing a major effect.
The association of Chinese and American antenatal care utilization indices with birth outcomes
Authors: Zhou Haibo , Yang Yi , Chi Peihan , Cheng Haoyue , Alifu Xialidan , Qiu Yiwen , Huang Ye , Zhang Libi , Ainiwan Diliyaer , Zhuang Yan , Liu Hui , Chen Zhi , Yu Yunxian
Published: August 2024

Objective

Few comparisons have been implemented between different prenatal care utilization indices and their effects on adverse outcomes. This study investigated the appropriateness of Chinese antenatal care (ANC) regulations and compared Chinese and American adequacy of prenatal care utilization (APNCU) scores.

Methods

From 2010 to 2022, the medical records of 60,114 pregnant women were collected from the electronic medical record system (EMRS) in Zhoushan, China. ANC utilization was measured using the APNCU score and five times antenatal care (ANC5). Birth weight outcomes, including small for gestational age (SGA) and large for gestational age (LGA), low birth weight (LBW), macrosomia, birth weight, and preterm birth (PTB), were utilized as outcomes. Multinomial, linear, and logistic regression were used to analyze the association of ANC5 and APNCU with outcomes, respectively. Crossover analysis was implemented to compare the interaction between ANC5 and APNCU on the outcomes.

Results

Women who received inadequate prenatal care had increased odds for PTB (ANC5: odds ratio (OR) = 1.12, 95% confidence interval (95%CI) = 1.03–1.21; APNCU: OR = 1.18, 95%CI: 1.07–1.29), delivering SGA infants (ANC5: OR = 1.13, 95%CI = 1.07–1.21; APNCU: OR = 1.11, 95%CI = 1.03–1.20). Crossover analysis revealed that inadequate prenatal care in APNCU only was significantly associated with an increased risk of PTB (OR = 1.48, 95%CI: 1.26–1.73).

Conclusion

Women with inadequate prenatal care in ANC5 or APNCU were more likely to suffer from adverse birth outcomes, including PTB, birth weight loss, SGA, and LBW. It indicated that adequate prenatal care is necessary for pregnant women. However, there were interactions between ANC5 and APNCU on PTB, with inadequate prenatal care use by APNCU showing the highest risk of PTB. This indicates that APNCU would be a better tool for evaluating prenatal care use.
Long-term effects of an alcohol prevention program at licensed premises: a Swedish 20-year follow-up study
Authors: Elgán Tobias H. , Andréasson Sven , Gripenberg Johanna
Published: August 2024

Background

In 1996, a multicomponent community-based alcohol prevention program in Responsible Beverage Service (RBS) targeting licensed premises was developed by STAD (Stockholm Prevents Alcohol and Drug Problems) and implemented in Stockholm, Sweden. The program consists of community mobilization and collaboration, training, and enforcement. Early evaluations have shown a significant increase in the refusal rates of alcohol service to intoxicated patrons, from 5% in 1996 to 70% in 2001, and a 29% decrease in the frequency of police-reported violence. A cost-effectiveness analysis showed a cost-saving ratio of 1:39. The program was institutionalized by a collaborative steering group consisting of community stakeholders. This study aimed to evaluate the long-term effects over 20 years of the RBS program. The indicator chosen was the rate of alcohol overserving to obviously intoxicated patrons at licensed premises in Stockholm.

Methods

A 20-year follow-up study was conducted using the same procedure as the baseline and previous follow-ups. Professional male actors (pseudopatrons) were trained by an expert panel to enact a standardized scene of obvious alcohol-intoxication. In 2016, 146 licensed premises located in the central part of Stockholm were randomly selected and visited. A review of program implementation from its initiation 1996 was conducted, examining critical events, including commitment from key actors in the community, training of bar staff, and enforcement.

Results

At the 20-year follow-up, pseudopatrons were refused alcohol service in 76.7% of the attempts, which was at the same level (70%) as in the follow-up in 2001, thus indicating sustained effects of the RBS program. Compared with previous follow-ups, serving staff used more active intervention techniques in 2016 toward intoxicated patrons, such as refusing to take the order (56.9% in 2016 vs. 42.0% in 2001), and fewer passive techniques, such as ignoring patrons (6.5% in 2016 vs. 15.5% in 1999) or contacting a colleague (4.1% in 2016 vs. 25% in 2001).

Conclusion

The sustained long-term effects of the RBS program are unique and can be explained by the high level of institutionalization of the multicomponent program, which is still ongoing in Stockholm. These findings can inform the dissemination of the program to other countries and settings.
Mapping of MPH programs in terms of geographic distribution across various universities and institutes of India—A desk research
Authors: Dhagavkar Pooja S. , Angolkar Mubashir , Nagmoti Jyoti , Zodpey Sanjay
Published: August 2024

Background

Landscaping studies related to public health education in India do not exclusively focus on the most common Masters of Public Health (MPH) program. The field of public health faces challenges due to the absence of a professional council, resulting in fragmented documentation of these programs. This study was undertaken to map all MPH programs offered across various institutes in India in terms of their geographic distribution, accreditation status, and administration patterns.

Methodology

An exhaustive internet search using various keywords was conducted to identify all MPH programs offered in India. Websites were explored for their details. A data extraction tool was developed for recording demographic and other data. Information was extracted from these websites as per the tool and collated in a matrix. Geographic coordinates obtained from Google Maps, and QGIS software facilitated map generation.

Results

The search identified 116 general and 13 MPH programs with specializations offered by different universities and institutes across India. India is divided into six zones, and the distribution of MPH programs in these zones is as follows, central zone has 20 programs; the east zone has 11; the north zone has 35; the north-east zone has 07; the south zone has 26; and the west zone has 17 MPH programs. While 107 are university grants commission (UGC) approved universities and institutes, only 46 MPH programs are conducted by both UGC approved and National Assessment and Accreditation Council (NAAC) accredited universities and institutes. Five universities are categorized as central universities; 22 are deemed universities; 51 are private universities; and 29 are state universities. Nine are considered institutions of national importance by the UGC, and four institutions are recognized as institutions of eminence. All general MPH programs span 2 years and are administered under various faculties, with only 27 programs being conducted within dedicated schools or centers of public health.

Conclusion

The MPH programs in India show considerable diversity in their geographic distribution, accreditation status, and administration pattern.
Lessons from polio eradication: a synthesis of implementation strategies for global health services delivery from a scoping review
Authors: Neel Abigail H. , Olateju Adetoun , Peters Michael A. , Schleiff Meike , Alonge Olakunle
Published: August 2024

Introduction

There is limited guidance on strategies for delivering complex global health programs. We synthesized available evidence on implementation strategies and outcomes utilized in the global polio eradication initiative (GPEI) across low and middle-income country (LMIC) settings.

Methods

We nested our scoping review into a literature review conducted as part of a parent study, STRIPE. This review systematically searched PubMed for articles between 1 January 1988 and 25 April 2018 using polio search terms. Strategies from included studies were organized according to the Expert Recommendations for Implementing Change (ERIC) framework, specified using Proctor's framework, and linked to various outcomes (implementation, services delivery, impact).

Results

152 unique articles fulfilled our inclusion criteria (from 1,885 articles included in the parent study). Only 43 out of the 152 articles described a suitable quantitative study design for evaluating outcomes. We extracted 66 outcomes from the 43 unique studies. Study publication dates ranged from 1989 to 2018 and represented diverse country settings. The most common implementation strategies were developing mechanisms for feedback, monitoring, and evaluation (n = 69); increasing awareness among the population (n = 58); involving stakeholders, workers, and consumers in the implementation efforts (n = 46); conducting workshops (n = 33); using mass media (n = 31); and building robust record systems to capture outcomes (n = 31). Coverage (n = 13) and morbidity (n = 12) were the most frequently identified outcomes, followed by effectiveness (n = 9) and fidelity (n = 6). Feasibility and sustainability were rarely evaluated.

Conclusions

This review provides a catalogue of implementation strategies and outcomes relevant for advancing global health services delivery in LMICs drawing from the GPEI. Implementation strategies reviewed were poorly described and not adequately linked to outcomes. It calls for additional implementation research to unravel the mechanisms of implementation strategies and their effectiveness, and adaptation of the ERIC framework in LMICs.
Do you wanna dance? Tales of trust and driving trust factors in robot medication counseling in the pharmacy context
Authors: Hägglund Susanne , Andtfolk Malin , Rosenberg Sara , Wingren Mattias , Andersson Sören , Nyholm Linda
Published: August 2024

Introduction: The sustainable implementation of socially assistive robots in a pharmacy setting requires that customers trust the robot. Our aim was to explore young adults’ anticipations of and motives for trusting robot medication counseling in a high-stakes scenario.

Methods: Through a co-creation approach, we co-designed a prototype application for the Furhat platform together with young adults. In-lab testing of a pharmacy scenario, where the robot provides medication counseling related to emergency contraceptive pills, was conducted to deepen our understanding of some factors driving young adults’ initial trust establishment and anticipations of interacting with a robot in a high-stakes scenario. Qualitative data from interviews with six study participants were analyzed using inductive, reflexive thematic analysis and are presented through a narrative approach.

Results: We outline five tales of trust characterized by personas. A continuum of different anticipations for consulting a robot in medication counseling is presented, ranging from low to high expectations of use. Driving factors in the initial trust establishment process are position, autonomy, boundaries, shame, gaze, and alignment.

Discussion: The article adds to the understanding of the dimensions of the multifaceted trust concept, of driving trust factors, and of the subsequent anticipation to trust robots in a high-stakes pharmacy context.
Cross-referencing unidentified fish sound data sets to unravel sound sources: a case study from the Temperate Northern Atlantic
Authors: Vieira Manuel , Ríos Noelia , Muñoz-Duque Sebastian , Pereira Jodanne , Carriço Rita , Fernandez Marc , Monteiro João G. , Pais Miguel Pessanha , Quintella Bernardo R. , Silva Gonçalo , Silva Rodrigo P. , Fonseca Paulo J. , Amorim M. Clara P.
Published: August 2024

There is growing evidence that studying aquatic acoustic communities can provide ecologically relevant information. Understanding these communities may offer unique insights into species behaviour and ecology, while consolidating passive acoustic monitoring as a tool for mapping the presence of target species or estimating changes in aquatic biodiversity. Fish can be significant soundscape contributors, but most soniferous fish species are yet to be identified. Here, we crossed information of three key fish acoustic communities in the Lusitanian Province of the Temperate Northern Atlantic (the Madeira archipelago, the Azores archipelago and Arrábida in mainland Portugal) to unveil potential sources of unidentified fish sounds. We found that the three communities shared various sound types and we were able to narrow down the list of possible fish sound sources. Several sound types were suggested to be produced by species of the Pomacentridae, Scorpaenidae and Serranidae families. We also observed that the sound type /kwa/, associated with Scorpaena spp., exhibited more variations in the geographic area where more species of this genus are known to be present. This study showcases that, as databases of unidentified fish sounds continue to grow, future comparisons of multiple acoustic communities may provide insights into unknown fish sound sources and sound types.
Legal mobilization dilemmas in the Nordics – an autoethnographic reflection on the role of scholars in the asylum commission
Authors: Lundberg Anna
Published: August 2024

The present article investigates key dilemmas in collective legal mobilization initiatives in the field of asylum and migrants’ rights. Focusing on my own experiences from working in the Asylum Commission – a trans-sectional mobilization initiative that ran in Sweden from 2019 to 2022, involving researchers, civil society representatives, and professionals – I analyze two central dilemmas that characterized our work. First, I consider how we collectively struggled for the legal right to asylum and through this struggle also reproduced injustices and potential border control harms which are embedded in asylum regulations. Second, I analyze how the Commission strived to provide a knowledge-based account of the consequences of legislative changes post the long summer of migration in 2015 that would have an impact on future legislation, while simultaneously taking an open stand in solidarity with people who were excluded from the legislative process; i.e., asylum seekers. The article underlines the need for sociolegal research that highlights ways to address dilemmas in legal mobilization work and offers empirical insights from collective mobilization for migrants’ rights in a Northern European country.
Twenty-first century knowledge mapping on oral diseases and physical activity/exercise, trends, gaps, and future perspectives: a bibliometric review
Authors: Gomes Thamires Campos , Gomes Moura José Lucas , Baia-da-Silva Daiane Claydes , Lima Rafael Rodrigues , Rodrigues Patrícia de Almeida
Published: August 2024

Maintenance and improvement of an individual's overall well-being require a multidisciplinary approach that encompasses everything from oral health care to regular physical exercise. The notion that poor oral health can influence general health and athletic performance has sparked an interest in this relationship. This study offers an overview of relevant research and a knowledge map,and discusses publication metrics and key topics concerning the relationship between physical activity or exercise and oral diseases. We searched the Web of Science database for articles published in the 21st century that addressed the relationship between physical activity and oral diseases. Under the stipulated inclusion criteria, a rigorous selection process yielded 276 from 3,883 retrieved articles. The articles were classified by what was assessed as follows: occurrence of oral diseases in athletes or sports enthusiasts (n = 174); impact of physical activity or exercise on the oral cavity (n = 59); effects of oral changes on sports performance and physical fitness (n = 31); and the connection between oral health status, physical activity or exercise, and systemic conditions (n = 12). Orofacial trauma has received the most attention among all investigated oral diseases. However, there is a need for greater attention of dysfunctional habits that can contribute to premature tooth wear, as well as oral inflammatory diseases that can have systemic implications. This mapping can encourage the development of new primary research.
Statistical approaches for assessing meat quality and heifer rumen histology based on dietary forage
Authors: Benito-Díaz Alberto , Sarmiento-García Ainhoa , García-García Juan José , Vieira Ceferina , Domínguez Esperanza , Bodas Rodríguez Raúl , Gómez-Gordo Luis , Vicente-Galindo Purificación
Published: August 2024

Introduction

Feeding local forages to ruminants is a promising strategy for enhancing metabolic processes, promoting sustainable farming, and improving product quality. However, studies comparing the effects of different forages on rumen histology and meat attributes of heifers are limited and variable.

Material and methods

This study evaluated the benefits of incorporating local forages into heifer diets by comparing barley straw (BS) and oat hay (OH) on heifer attributes focusing on meat quality (MQ) and rumen status (RS). Sixteen crossbred (Charolais x Limousin) female heifers (7 months of age, 263 ± 10.50 kg) were randomly assigned to two dietary treatments (BS or OH) over 120 days.

Results and discussion

Heifers fed OH showed enhanced RS (p < 0.05), characterized by improved intestinal epithelial integrity and a lower percentage of hyperpigmented cells, suggesting a potential reduction in inflammatory processes compared to BS, which may indicate a lower risk of metabolic diseases. Despite this, no significant differences (p > 0.05) were found in animal performance, chemical composition, and technological properties of the meat between the dietary groups, while lower levels (p < 0.05) of certain saturated fatty acids (C12:0, C15:0, and C22:0) were found in the meat from heifers fed OH. Principal component analysis (PCA) reduced the variables and demonstrated that all variables assessed can be condensed into four new variables explaining 75.06% of the variability. Moreover, biplot analysis reveals that the OH diet could be discriminated from BS. Our findings suggest that OH is a valuable fiber source, positively influencing certain heifer attributes, and supporting sustainable animal agriculture practices.
DNA damage (8-OHdG) and telomere length in captive Psittacidae birds with different longevity
Authors: Domínguez-de-Barros Angélica , Sifaoui Inés , Dorta-Guerra Roberto , Lorenzo-Morales Jacob , Castro-Fuentes Rafael , Córdoba-Lanús Elizabeth
Published: August 2024

Aging is a complex process influenced by internal and external factors. Oxidative stress damages DNA, leading to 8-hydroxy-2’ deoxyguanosine formation (8-OHdG). Telomere shortening is considered a biomarker of aging and oxidative stress may enhance its attrition. The ability to manage and repair oxidative stress varies among species and life histories. Avian species, such as Psittacidae birds, exhibit exceptional lifespans despite their physiological characteristics that might suggest otherwise. This study investigates 8-OHdG levels in serum samples from long- and short-lived birds of the order Psittaciformes, examining their relationship with telomere length and antioxidant capacity based on lifespan strategies. Among 43 individuals analyzed 26 belonged to the “long-lived species” group and 17 belonged to the “short-lived species” one. Relative telomere length (rTL) was measured in DNA isolated from whole blood by qPCR, and oxidative stress markers, such as Total Antioxidant Capacity (TAC) and 8-OHdG, were determined by spectrophotometry in serum samples. Long-lived birds had longer rTL than short-lived ones [1.308 ± 0.11 vs. 0.565 ± 0.13, (p < 0.001)]. On the contrary, short-lived birds showed more DNA damage than their counterparts [3.847 ± 0.351 vs. 2.012 ± 0.308, respectively, (p < 0.001)]. Old birds had shorter rTL than young ones, for both longevity groups (p < 0.001). Although no correlation was found between 8-OHdG levels and age, nor 8-OHdG and telomere length, long-lived birds exhibited 75.42-unit increased TAC levels when increased 8-OHdG concentrations (p = 0.046). These findings highlight distinct patterns of telomere length and oxidative stress influenced by lifespan strategies among avian longevity groups.
First microscopic, pathological, epidemiological, and molecular investigation of Leucocytozoon (Apicomplexa: Haemosporida) parasites in Egyptian pigeons
Authors: Elshahawy Ismail Saad , Mohammed Eman Sayed , Mawas Amany Sayed , Shibat El Hamd Dina M. W. , Ali Esraa , Alghamdi Abeer M. , Alzaylaee Hind , Elmahallawy Ehab Kotb
Published: August 2024

Introduction

Leucocytozoon is an intracellular blood parasite that affects various bird species globally and is transmitted by blackfly vectors. This parasite is responsible for leucocytozoonosis, a disease that results in significant economic losses due to reduced meat and egg production. There is limited knowledge about the epidemiological pattern of leucocytozoonosis and its causative species in Egypt, particularly in pigeons.

Methods

The current study involved the collection of 203 blood samples from domestic pigeons from various household breeders and local markets across Qena Province, Upper Egypt. Samples were initially examined for potential Leucocytozoon infection using blood smears, followed by an evaluation of associated risk factors. Molecular identification of the parasite in selected samples (n = 11), which had initially tested positive via blood smears, was further refined through nested PCR and sequence analysis of the mitochondrial cytochrome b gene to ascertain the Leucocytozoon species present. Additionally, histopathological examination of the liver, spleen, and pancreas was conducted on animals that tested positive by blood smears.

Results

Interestingly, 26 out of 203 samples (12.08%) had confirmed Leucocytozoon infections based on microscopic analysis. Additionally, all 11 samples that initially tested positive via blood smears were confirmed positive through nested PCR analysis, and their sequencing revealed the presence of Leucocytozoon sabrazesi, marking the first report of this parasite in Egypt. The study into potential risk factors unveiled the prevalence of Leucocytozoon spp. seems host gender-dependent, with males exhibiting a significantly higher infection rate (33.33%). Additionally, adult birds demonstrated a significantly higher infection prevalence than squabs, suggesting an age-dependent trend in prevalence. Seasonality played a significant role, with the highest occurrence observed during summer (37.25%). Histopathological examination revealed the presence of numerous megaloschizonts accompanied by lymphocytic infiltration and multiple focal areas of ischemic necrosis.

Conclusion

To our knowledge, this is the first study to shed light on the epidemiological characteristics and molecular characterization of leucocytozoonosis in pigeons in Egypt. Further research endeavors are warranted to curb the resurgence of Leucocytozoon parasites in other avian species across Egypt, thereby refining the epidemiological understanding of the disease for more effective control and prevention measures.
Pathogenicity characteristics of different subgenotype pseudorabies virus in newborn piglets
Authors: Xu Lei , Tao Qian , Xu Tong , Yang Yanting , Zhang Yang , Liu Zheyan , Zhou Yuancheng , Zhu Ling , Xu Zhiwen
Published: August 2024

Pseudorabies virus is a major pathogen in the pig industry, causing substantial economic losses. The emergence of pseudorabies virus variant strains in China has led to extensive spread, raising concerns about their potential impact. However, the differences in pathogenicity between the classical strains and the variant strains of genotype II are not well understood. In this study, we isolated three pseudorabies virus strains to evaluate their replication characteristics and to examine the differences in virulence genes among various subgenotypes strains. Additionally, a piglet infection model was utilized to investigate the clinical features of infection, tissue tropism, and the inflammatory responses induced by these strains. Our results showed that the genotype II variant strains (MS, XJ, LS, and CZ) had significantly larger plaque sizes and higher replication capacities than the genotype II classical strain Fa. The animal experiments revealed significant differences in pathogenicity among the pseudorabies virus subgenotype strains, with the variant strains showing higher mortality rates, more severe clinical symptoms, increased nasal virus shedding, and a more robust inflammatory response compared to the genotype II classical strain. There were also notable differences in tissue tropism among the strains. In terms of tissue viral loads, the genotype II variant strains did not exhibit a significant advantage over the genotype I classical strain. Furthermore, our findings indicate that antibodies against the genotype II classical strains have a reduced neutralizing capacity against the genotype II variant strains. On the other hand, antibodies against the genotype II variant strains displayed similar neutralizing abilities against both classical and variant strains. Overall, these findings offer important insights into the distinctions among pseudorabies virus subgenotypes and their implications for the clinical control of pseudorabies virus infections in pig farming.
Long-Term Cumulative Effects of Wildfires on Soil-Vegetation Dynamics in the “Baixa Limia–Serra do Xurés” Natural Park
Authors: García-Redondo Concepción , Díaz-Raviña Montserrat , Regos Adrián
Published: August 2024

Wildfires are recognized as major contributors to forest loss and soil degradation on a global scale. Understanding the cumulative effects of fire regimes on forest ecosystems and soil dynamics necessitates a deeper exploration of wildfire-vegetation-soil interactions over the long term. This study delves into the wildfire-landscape dynamics within the “Baixa Limia Serra do Xurés” Natural Park, a region prone to fires in Galicia, Spain. By analyzing available statistical and remote sensing data, we identified significant shifts in fire regimes and landscape dynamics between the periods of 2000–2010 and 2010–2020. Our findings indicate a potential extension of the fire season, reflecting the impacts of climate change. Despite improvements in firefighting capabilities, the occurrence of large fires is on the rise in the Natural Park, underscoring the need for proactive management strategies in such areas. Notably, significant fire events in 2011, 2016, 2017, and 2020 extensively affected wooded areas, constituting the majority of the burned area. Shrubs and forests emerged as particularly vulnerable, with varying degrees of burn severity influencing post-fire vegetation recovery rates. While shrublands expanded their coverage between 2000 and 2010, rocky areas with sparse vegetation showed an increase over the subsequent decade (2010–2020), indicating soil degradation and potential desertification in areas affected by recurrent and severe fires, especially within zones designated for the highest levels of protection (with fire rotation periods of less than 1 year). In conclusion, this study provides valuable insights into the impacts of wildfires, changes in land cover, and post-fire soil-vegetation dynamics, which can inform management and conservation efforts in fire-prone mountainous regions. Leveraging advanced remote sensing techniques enables the monitoring of cumulative soil degradation resulting from repeated wildfires over extended periods.
Precedence Table Construction Algorithm for CFGs Regardless of Being OPGs
Authors: Lizcano Leonardo , Angulo Eduardo , Márquez José
Published: August 2024

Operator precedence grammars (OPG) are context-free grammars (CFG) that are characterized by the absence of two adjacent non-terminal symbols in the body of each production (right-hand side). Operator precedence languages (OPL) are deterministic and context-free. Three possible precedence relations between pairs of terminal symbols are established for these languages. Many CFGs are not OPGs because the operator precedence cannot be applied to them as they do not comply with the basic rule. To solve this problem, we have conducted a thorough redefinition of the Left and Right sets of terminals that are the basis for calculating the precedence relations, and we have defined a new Leftmost set. The algorithms for calculating them are also described in detail. Our work’s most significant contribution is that we establish precedence relationships between terminals by overcoming the basic rule of not having two consecutive non-terminals using an algorithm that allows building the operator precedence table for a CFG regardless of whether it is an OPG. The paper shows the complexities of the proposed algorithms and possible exceptions to the proposed rules. We present examples by using an OPG and two non-OPGs to illustrate the operation of the proposed algorithms. With these, the operator precedence table is built, and bottom-up parsing is carried out correctly.
Mesospheric Ozone Depletion during 2004–2024 as a Function of Solar Proton Events Intensity
Authors: Doronin Grigoriy , Mironova Irina , Bobrov Nikita , Rozanov Eugene
Published: August 2024

Solar proton events (SPEs) affect the Earth’s atmosphere, causing additional ionization in the high-latitude mesosphere and stratosphere. Ionization rates from such solar proton events maximize in the stratosphere, but the formation of ozone-depleting nitrogen and hydrogen oxides begins at mesospheric altitudes. The destruction of mesospheric ozone is associated with protons with energies of about 10 MeV and higher and will strongly depend on the intensity of the flux of these particles. Most studies investigating the impact of SPEs on the characteristics of the middle atmosphere have been based on either simulations or reanalysis datasets, and some studies have used satellite observations to validate model results. We study the impact of SPEs on cold-season ozone loss in both the northern and southern hemispheres using Aura MLS mesospheric ozone measurements over the 2004 to 2024 period. Here, we show how strongly SPEs can deplete polar mesospheric ozone in different hemispheres and attempt to evaluate this dependence on the intensity of solar proton events. We found that moderate SPEs consisting of protons with an energy of more than 10 MeV and a flux intensity of more than 100 pfu destroy mesospheric ozone in the northern hemisphere up to 47% and in the southern hemisphere up to 33%. For both hemispheres, the peak of winter ozone loss was observed at about 76 km. In the northern hemisphere, maximum winter ozone loss was observed on the second day after a solar proton event, but in the southern hemisphere, winter ozone depletion was already detected on the first day. In the southern hemisphere, mesospheric ozone concentrations return to pre-event levels on the ninth day after a solar proton event, but in the northern hemisphere, even on the tenth day after a solar proton event, the mesospheric ozone layer may not be fully recovered. The strong SPEs with a proton flux intensity of more than 1000 pfu lead to a maximum winter ozone loss of up to 85% in the northern hemisphere, and in the southern hemisphere winter, ozone loss reaches 73%.
Evaluation of Combined Chemotherapy and Genomic-Driven Targeted Therapy in Patient-Derived Xenografts Identifies New Therapeutic Approaches in Squamous Non-Small-Cell Lung Cancer Patients
Authors: Decaudin Didier , Némati Fariba , Masliah Planchon Julien , Seguin-Givelet Agathe , Lefevre Marine , Etienne Vesnie , Ahnine Harry , Peretti Quentin , Sourd Laura , El-Botty Rania , Huguet Lea , Lagha Sarah , Hegarat Nadia , Roman-Roman Sergio , Bièche Ivan , Girard Nicolas , Montaudon Elodie
Published: August 2024

The combination of chemotherapy and targeted therapy has been validated in non-small-cell lung cancer (NSCLC) patients with EGFR mutations. We therefore investigated whether this type of combined approach could be more widely used by targeting other genetic alterations present in NSCLC. PDXs were generated from patients with NSCLC adenocarcinomas (ADCs) and squamous-cell carcinomas (SCCs). Targeted NGS analyses identified various molecular abnormalities in the MAPK and PI3K pathways and in the cell cycle process in our PDX panel. The antitumor efficacy of targeted therapies alone or in combination with chemotherapy was then tested in vivo. We observed that trametinib, BKM120, AZD2014 and palbociclib increased the efficacy of each chemotherapy in SCC PDXs, in contrast to a non-insignificant or slight improvement in ADCs. Furthermore, we observed high efficacy of trametinib in KRAS-, HRAS- and NRAS-mutated tumors (ADCs and SCCs), suggesting that the MEK inhibitor may be useful in a wider population of NSCLC patients, not just those with KRAS-mutated ADCs. Our results suggest that the detection of pathogenic variants by NGS should be performed in all NSCLCs, and particularly in SCCs, to offer patients a more effective combination of chemotherapy and targeted therapy.
Tumor-Like Lesions in the Craniovertebral Junction: A Case Series, Systematic Review, and Meta-Analysis
Authors: Pop Maria Mihaela , Bouros Dragos , Klimko Artsiom , Pop Laura Ancuta , Topal Paula , Topal Anil , Florian Ioan Stefan
Published: August 2024

Background: Tumor-like lesions at the craniovertebral junction mimic tumors in clinical presentation and imaging. Our study focuses on three common developmental pathologies—epidermoids, dermoids and neurenteric cysts. Methods: We conducted a retrospective analysis of a case series and a meta-analysis of 170 patients from 119 reports. Results: Neurenteric cysts predominated (81.2%). Anterior cysts were linked to neurenteric cysts, while posterior ones correlated with dermoid/epidermoid cysts (p < 0.001). Complications occurred in 27.2% of cases, with cranial nerve paresis being the most common. Most patients had excellent outcomes (75.2%) with low recurrence rates (12%). Dermoid cysts were more associated with anomalies (p < 0.001). Among 138 neurenteric cyst cases, 15 experienced recurrence, with predictors including ages 51–60 and over 70, subtotal resection, complications, and poor outcomes (p < 0.001). Cysts with total resection were significantly less likely to adhere to surrounding brain tissue (p < 0.001). CSF diversion was correlated with older age (p = 0.010) and various complications (p < 0.001). Age affected outcomes, and the hydrocephalus was linked to poor outcomes (p = 0.002). Conclusions: This meta-analysis underscores the importance of total resection in minimizing recurrence rates and emphasizes meticulous preoperative planning and imaging. Our results indicate that rim enhancement (p = 0.047) and poor outcome (p = 0.007) are significant factors associated with recurrence. Additionally, associated anomalies, as well as the patient’s age and overall health, significantly influence the surgical outcomes and the likelihood of recurrence.
Bootstrap Methods for Bias-Correcting Probability Distribution Parameters Characterizing Extreme Snow Accumulations
Authors: Pomeyie Kenneth , Bean Brennan
Published: August 2024

Accurately quantifying the threat of collapse due to the weight of settled snow on the roof of a structure is crucial for ensuring structural safety. This quantification relies upon direct measurements of the snow water equivalent (SWE) of settled snow, though most weather stations in the United States only measure snow depth. The absence of direct load measurements necessitates the use of modeled estimates of SWE, which often results in the underestimation of the scale/variance parameter of the distribution of annual maximum SWE. This paper introduces a novel bias correction method that employs a bootstrap technique with regression-based models to calibrate the variance parameter of the distribution. The efficacy of this approach is demonstrated on real and simulated datasets. The findings reveal varied levels of success, with the efficacy of the proposed approach being inherently dependent on the quality of the selected regression-based model. These findings demonstrate that integrating our approach with a suitable regression-based model can produce unbiased or nearly unbiased annual maximum SWE distribution parameters in the absence of direct SWE measurements.