bluuebunny/crossref_metadata_2025 huggingface dataset:
Cell Membrane Adaptations Mediate β-Lactam-Induced Resensitization of Daptomycin-Resistant (DAP-R) Staphylococcus aureus In Vitro
Authors: Mishra Nagendra N. , Bayer Arnold S. , Baines Sarah L. , Hayes Ashleigh S. , Howden Benjamin P. , Lapitan Christian K. , Lew Cassandra , Rose Warren E.
Published: May 2021

The reversal of daptomycin resistance in MRSA to a daptomycin-susceptible phenotype following prolonged passage in selected β-lactams occurs coincident with the accumulation of multiple point mutations in the mprF gene. MprF regulates surface charge by modulating the content and translocation of the positively charged cell membrane phospholipid, lysyl-phosphatidylglycerol (LPG). The precise cell membrane adaptations accompanying such β-lactam-induced mprF perturbations are unknown. This study examined key cell membrane metrics relevant to antimicrobial resistance among three daptomycin-resistant MRSA clinical strains, which became daptomycin-susceptible following prolonged exposure to cloxacillin (‘daptomycin-resensitized’). The causal role of such secondary mprF mutations in mediating daptomycin resensitization was confirmed through allelic exchange strategies. The daptomycin-resensitized strains derived either post-cloxacillin passage or via allelic exchange (vs. their respective daptomycin-resistant strains) showed the following cell membrane changes: (i) enhanced BODIPY-DAP binding; (ii) significant reductions in LPG content, accompanied by significant increases in phosphatidylglycerol content (p < 0.05); (iii) no significant changes in positive cell surface charge; (iv) decreased cell membrane fluidity (p < 0.05); (v) enhanced carotenoid content (p < 0.05); and (vi) lower branched chain fatty acid profiles (antiso- vs. iso-), resulting in increases in saturated fatty acid composition (p < 0.05). Overall, the cell membrane characteristics of the daptomycin-resensitized strains resembled those of parental daptomycin-susceptible strains. Daptomycin resensitization with selected β-lactams results in both definable genetic changes (i.e., mprF mutations) and a number of key cell membrane phenotype modifications, which likely facilitate daptomycin activity.
Review of Methods Used for Diagnosing Tuberculosis in Captive and Free-Ranging Non-Bovid Species (2012–2020)
Authors: Thomas Rebecca , Chambers Mark
Published: May 2021

The Mycobacterium tuberculosis complex (MTBC) is a group of bacteria that cause tuberculosis (TB) in diverse hosts, including captive and free-ranging wildlife species. There is significant research interest in developing immunodiagnostic tests for TB that are both rapid and reliable, to underpin disease surveillance and control. The aim of this study was to carry out an updated review of diagnostics for TB in non-bovid species with a focus predominantly on those based on measurement of immunity. A search was carried out to identify relevant papers meeting a pre-defined set of inclusion criteria. Forty-one papers were identified from this search, from which only twenty papers contained data to measure and compare diagnostic performance using diagnostic odds ratio. The diagnostic tests from each study were ranked based on sensitivity, specificity, and diagnostic odds ratio to define high performing tests. High sensitivity and specificity values across a range of species were reported for a new antigenic target, P22 complex, demonstrating it to be a reliable and accurate antigenic target. Since the last review of this kind was undertaken, the immunodiagnosis of TB in meerkats and African wild dogs was reported for the first time. Suid species showed the most consistent immunological responses and highlight a potential dichotomy between humoral and cellular immune responses.
Tick-Borne Pathogens in Ticks Collected from Wild Ungulates in North-Eastern Poland
Authors: Michalski Mirosław M. , Kubiak Katarzyna , Szczotko Magdalena , Dmitryjuk Małgorzata
Published: May 2021

This study was carried out in north-eastern Poland during two hunting seasons between 2018 and 2020. Ticks (Ixodes ricinus and Dermacentor reticulatus) were removed from wild cervids and boars and examined for the presence of Borrelia spirochetes and Rickettsiales members: Rickettsia spp. and Anaplasma phagocytophilum. The present study contributes to the knowledge of even-toed ungulates, which are an important reservoir of the above-mentioned pathogens and a potential source of infections for humans through ticks as vectors. Almost 40% of the collected ticks (191 out of 484) were infected with the following pathogens: 3.3% with Borrelia spp., 19.2% with A. phagocytophilum and 26.9% with Rickettsia spp. Only the ticks collected from cervids carried Borrelia. Typing of the species DNA confirmed the presence of B. afzelii, B. garinii, B. lusitaniae and B. miyamotoi. An analysis of Rickettsia spp. sequences using the GenBank data revealed the presence of R. helvetica, R. raoultii and R. monacensis. Monoinfections (79.1%) dominated over co-infections (20.9%). Among co-infections, the most frequent was A. phagocytophilum/Rickettsia spp. (70%), however co-infections, including B. afzelii/A. phagocytophilum, B. afzelii/Rickettsia spp., B. miyamotoi/A. phagocytophilum and B. afzelii/B. garinii/B. lusitaniae, were also noted. Significant differences were observed in the affinity of some pathogens to their vectors. Thus, Borrelia spp. and A. phagocytophilum were more frequently detected in I. ricinus (5.3% and 23.1%) than in D. reticulatus (1.2% and 15.3%). Infection frequency with Rickettsia spp. was similar (approximately 25–29%) in both tick species. The prevalence of A. phagocytophilum and Rickettsia spp. in ticks removed from cervids was 19.8% and 27.1%, and in ticks from wild boars it was 13.3% and 24.4%, respectively.
Chromosome and Molecular Analyses Reveal Significant Karyotype Diversity and Provide New Evidence on the Origin of Aegilops columnaris
Authors: Badaeva Ekaterina D. , Chikida Nadezhda N. , Fisenko Andrey N. , Surzhikov Sergei A. , Belousova Maria K. , Özkan Hakan , Dragovich Alexandra Y. , Kochieva Elena Z.
Published: May 2021

Aegilops columnaris Zhuk. is tetraploid grass species (2n = 4x = 28, UcUcXcXc) closely related to Ae. neglecta and growing in Western Asia and a western part of the Fertile Crescent. Genetic diversity of Ae. columnaris was assessed using C-banding, FISH, nuclear and chloroplast (cp) DNA analyses, and gliadin electrophoresis. Cytogenetically Ae. columnaris was subdivided into two groups, C-I and C-II, showing different karyotype structure, C-banding, and FISH patterns. C-I group was more similar to Ae. neglecta. All types of markers revealed significant heterogeneity in C-II group, although group C-I was also polymorphic. Two chromosomal groups were consistent with plastogroups identified in a current study based on sequencing of three chloroplast intergenic spacer regions. The similarity of group C-I of Ae. columnaris with Ae. neglecta and their distinctness from C-II indicate that divergence of the C-I group was associated with minor genome modifications. Group C-II could emerge from C-I relatively recently, probably due to introgression from another Aegilops species followed by a reorganization of the parental genomes. Most C-II accessions were collected from a very narrow geographic region, and they might originate from a common ancestor. We suggest that the C-II group is at the initial stage of species divergence and undergoing an extensive speciation process.
Potential Infection Risks of the Wheat Stripe Rust and Stem Rust Pathogens on Barberry in Asia and Southeastern Europe
Authors: Sinha Parimal , Chen Xianming
Published: May 2021

Barberry (Berberis spp.) is an alternate host for both the stripe rust pathogen, Puccinia striiformis f. sp. tritici (Pst), and the stem rust pathogen, P. graminis f. sp. tritici (Pgt), infecting wheat. Infection risk was assessed to determine whether barberry could be infected by either of the pathogens in Asia and Southeastern Europe, known for recurring epidemics on wheat and the presence of barberry habitats. For assessing infection risk, mechanistic infection models were used to calculate infection indices for both pathogens on barberry following a modeling framework. In East Asia, Bhutan, China, and Nepal were found to have low risks of barberry infection by Pst but high risks by Pgt. In Central Asia, Azerbaijan, Iran, Kazakhstan, southern Russia, and Uzbekistan were identified to have low to high risks of barberry infection for both Pst and Pgt. In Northwest Asia, risk levels of both pathogens in Turkey and the Republic of Georgia were determined to be high to very high. In Southwest Asia, no or low risk was found. In Southeastern Europe, similar high or very high risks for both pathogens were noted for all countries. The potential risks of barberry infection by Pst and/or Pgt should provide guidelines for monitoring barberry infections and could be valuable for developing rust management programs in these regions. The framework used in this study may be useful to predict rust infection risk in other regions.
PRAT Proteins Operate in Organellar Protein Import and Export in Arabidopsis thaliana
Authors: Rossig Claudia , Gray John , Valdes Oscar , Springer Armin , Rustgi Sachin , von Wettstein Diter , Reinbothe Christiane , Rassow Joachim , Reinbothe Steffen
Published: May 2021

Chloroplasts need to import preproteins and amino acids from the cytosol during their light-induced differentiation. Similarly, chloroplasts have to export organic matter including proteins and amino acids during leaf senescence. Members of the PRAT (preprotein and amino acid transporter) family are candidate transporters for both processes. Here, we defined the role of two small PRAT gene families, At4g26670 and At5g55510 (HP20 subfamily) versus At3g49560 and At5g24650 (HP30 subfamily) during greening of etiolated plants and during leaf senescence. Using a combination of reverse genetics, protein biochemistry and physiological tools, evidence was obtained for a role of chloroplast HP20, HP30 and HP30-2 in protein, but not amino acid, import into chloroplasts. HP20, HP30 and HP30-2 form larger complexes involved in the uptake of transit sequence-less cytosolic precursors. In addition, we identified a fraction of HP30-2 in mitochondria where it served a similar function as found for chloroplasts and operated in the uptake of transit sequence-less cytosolic precursor proteins. By contrast, HP22 was found to act in the export of proteins from chloroplasts during leaf senescence, and thus its role is entirely different from that of its orthologue, HP20. HP22 is part of a unique protein complex in the envelope of senescing chloroplasts that comprises at least 11 proteins and contains with HP65b (At5g55220) a protein that is related to the bacterial trigger factor chaperone. An ortholog of HP65b exists in the cyanobacterium Synechocystis and has previously been implicated in protein secretion. Whereas plants depleted of either HP22 or HP65b or even both were increasingly delayed in leaf senescence and retained much longer stromal chloroplast constituents than wild-type plants, HP22 overexpressors showed premature leaf senescence that was associated with accelerated losses of stromal chloroplast proteins. Together, our results identify the PRAT protein family as a unique system for importing and exporting proteins from chloroplasts.
Monitoring of Influenza Vaccination Coverage among Pregnant Women in Germany Based on Nationwide Outpatient Claims Data: Findings for Seasons 2014/15 to 2019/20
Authors: Steffen Annika , Rieck Thorsten , Siedler Anette
Published: May 2021

Pregnant women and their infants are at increased risk for severe influenza-related complications. A decade has passed since influenza vaccination was first recommended for pregnant women in Germany in 2010; however, monitoring of vaccination coverage (VC) has not yet been implemented for this target group. Using nationwide outpatient claims data, we here provide results on influenza VC among pregnant women in Germany for seasons 2014/15 to 2019/20. For any given season, pregnant women were defined as women who had undergone prenatal health care in at least two consecutive quarters within a season. VC increased from 9.0% in season 2014/15 to 16.6% in 2019/20 (+84%), while most of the increase occurred from season 2016/17 (VC: 9.9%) onwards (+68%). Consistently across seasons, women in east Germany were 40 to 60% more likely to be vaccinated compared to women residing in west Germany. According to age, the highest VC was observed among women aged 35 to <40 years (2019/20: 18.2%). Despite noticeable increases in influenza VC during recent years, overall coverage remains low among pregnant women. Starting with this analysis, VC among pregnant women in Germany will be monitored on a yearly basis in order to detect trends and identify immunization gaps.
Türkiye’de Lisansüstü Tezlerde Artırılmış Gerçeklik Kullanımı Üzerine Araştırma Eğilimleri
Authors: TÜREL Yalın Kılıç , BAYER Harun
Published: May 2021

Günümüzde birçok alanda özellikle eğitim alanında kullanılan artırılmış gerçeklik teknolojisi öğrenme ortamlarının zenginleştirilmesine katkı sağlaması ile etkili ve kalıcı öğrenmelerin gerçekleştirilmesine yardımcı olmaktadır. Bu kazanımlarından ötürü artırılmış gerçeklik, eğitim ve öğretim alanında yapılan lisansüstü tez çalışmalarında yaygın olarak araştırılan bir konu haline gelmiştir. Bu araştırmada Türkiye’ de eğitim ve öğretim alanında, artırılmış gerçeklik konulu tezlerin araştırma eğilimleri belirlenmeye çalışılmıştır. Bu kapsamda 63 lisansüstü tezi, içerik analizi yöntemi ile analiz edilmiştir. Amaçlı örnekleme yöntemi ile seçilen tezler, makale sınıflama formu ile kayıt altına alınmış olup, betimsel analiz tekniği ile bulgular ortaya konulmuştur. Elde edilen sonuçlara göre; artırılmış gerçeklik teknolojisinin eğitime entegrasyonunun kolay ve etkili olması sebebiyle araştırmacılar tarafından daha çok tercih edilebildiği, teknoloji ile iç içe olmasından ötürü Bilgisayar ve Öğretim Teknolojileri Eğitimi anabilim dalında artırılmış gerçeklik konulu tezlerin daha çok hazırlandığı ve müfredata uygun ve etkili olmasından ötürü en fazla ilkokul ve ortaokul kademeleri kapsamında araştırmaların gerçekleştiği gibi eğilim durumları tespit edilebilmiştir. Araştırma sonuçlarına göre nitel araştırma sayısının artırılması gerektiği, öğrenmenin gerçekleştiği çeşitli kademelerde ve artırılmış gerçekliğin entegrasyonunun sağlandığı farklı branşlardaki araştırmalarının sayısının artırılmasının alana önemli katkılar sağlayacağı düşünülmektedir.
Análisis de sistemas mecánicos utilizando sistemas CAE, para estudiantes de ingeniería mecatrónica
Authors: Hernández-Zempoaltecatl Rodrigo , Cano-Corona Ariana , Pérez-Serrano Froylán , Méndez-Zapata Elías
Published: May 2021

This work shows that the fundamentals of CAE computeraided engineering systems can be used as an effective tool for optimizing the analysis of mechanical systems and / or manufacturing processes in mechatronic engineering subjects. The simulation of operating conditions, as well as the analysis of different working conditions such as stress analysis, thermal analysis, process optimization and product optimization, allows the CAE tool to be used in a wide variety of processes from previous designs to digitization of reverse engineering processes. During the development of technological skills as mechatronic engineers, CAE tools are essential for students to simulate processes and operating conditions that integrate manufacturing machines or cells. Given the wide variety of tools, CAE techniques can be developed by different methods, however in this case, finite element analysis (FEA) will be used, as a numerical resolution technique that considers that any component can be particularized, in a set of small elements with simple geometry and known physical behavior, this method is generally applied to different engineering fields.
Evaluación de un clasificador de textos digitales basado en el contenido semántico a través de ontologías
Authors: Hernández-García Héctor Daniel , Navarrete-Arias Dulce J., , Pérez-Bautista / Mario , Paredes-Reyes Eliud
Published: May 2021

Nowadays, the generation of information through digital text documents has increased exponentially, so there is a need to store documents in mass storage devices such as high capacity hard discs, storage servers, the cloud and others. However, the storage that is carried out lacks a thematic organization, therefore, a search for information becomes complex. Given this problem, this publication describes the development of a system that has the purpose of classifying a digital text document based on the thematic content. This system implements ontologies to achieve a better classification by taking advantage of its characteristics. The system is divided into five tasks: the first is the implementation of a word count to create a frequency vector; The second task performs a refinement on the frequency vector to eliminate the sentence connectors and prepositions; the third task orders the vector from the highest to the lowest frequency; the fourth task takes the most significant set of frequencies vector, in which the ontology of a domain is applied and the relation that the words have to determine the thematic of the document is sought; and the fifth task is to organize the documents in a folder structure based on the identified domains. The system was developed with the incremental development methodology. To validate the operation of the system, a set of tests was carried out in a controlled scenario in order to verify the correct classification of the documents.
Efecto del tiempo de electrodepósito de la fase sensibilizadora en DSSC empleando TiO2 como semiconductor
Authors: Caudillo-Caudillo Luisa Marcela , Salazar-Hernández Mercedes , Alvarado-Montalvo Lucía Guadalupe , Rodríguez-Rodríguez Carolina De Jesús
Published: May 2021

In this work, a solar cell sensitized with dye (DSSC) was developed using Titanium Dioxide as semiconductor metal oxide; the dye used was amaranth, this dye can be used for this purpose due to the chromophoric groups present in the molecule and the anchor groups related to TiO2. The tests carried out were the measurement of photovoltaic response (current and voltage) in cells where the electrodeposition time of the dye was varied at a voltage of 1 V; the results show that the efficiencies vary according to time, registering values of: 0.014% for a time of 15 s, 0.009% at 25 s, 0.18% at 35 s, 0.02% at 45 s and 0.083% at 55 s , the above shows that the best electro-deposit time is 35 s due to in this parameter, the system showed the best efficiency and energy stability.
МАЛЮНКИ І ГРАВЮРИ ДРУГОЇ ПОЛ. ХІХ – 1960-х РОКІВ ІЗ ВИДАМИ КАМ’ЯНЦЯ-ПОДІЛЬСЬКОГО ЯК ДЖЕРЕЛО ІКОНОГРАФІЇ МІСТА (ЗА МАТЕРІАЛАМИ ПОШТОВИХ ЛИСТІВОК)
Authors: Паур Ірина
Published: May 2021

Проаналізовано репродукції робіт художників другої половини ХІХ – середини ХХ століття на поштових листівках із видами Кам’янця-Подільського. Встановлено, що вони є цінним іконографічним джерелом, а їх сюжети дозволяють суттєво розширити уявлення про містобудівну та планувальну структуру міста, його забудову,окремі архітектурні пам’ятки. Підкреслено інформаційний потенціал іконографічних творів Н. Орди, М. Тшебінського, В. Гаґенмейстера та ін. в історико-архітектурній науці, пам’яткоохоронній та реставраційній сферах.
КОЗАЦЬКА ТЕМА В УКРАЇНСЬКІЙ НАРОДНО-СЦЕНІЧНІЙ ХОРЕОГРАФІЇ 1950–1980 РОКІВ ЯК ЗАСІБ ТРАНСЛЯЦІЇ ЕТНОКУЛЬТУРНОЇ ІДЕНТИЧНОСТІ
Authors: Климчук Ірина
Published: May 2021

Стаття присвячена виявленню специфіки трансляції етнокультурної ідентичності через танці козацькоїтематики у 1950–1980-х рр. в УРСР. Доведено, що в умовах повсюдної пропаганди в СРСР інтернаціоналізму тадружби народів, через сценічні образи козаків відбувалася своєрідна ідейна українізація. Козацька ідея,інтерпретована хореографічними засобами в професійних та самодіяльних колективах народно-сценічного танцю утой період («Запорожці», «Гопак», «Повзунець», «Про що верба плаче» у постановці П. Вірського, «Запорожці» упостановці Л. Калініна та ін.), стала одним із важливих чинників формування української національної ідентичності
СЦЕНОГРАФІЧНІ ШКОЛИ УКРАЇНИ ХХ СТОРІЧЧЯ У ФОРМУВАННІ ТВОРЧОГО ОБЛИЧЧЯ ТЕТЯНИ МЕДВІДЬ
Authors: Руденко-Краєвська Наталія
Published: May 2021

Уперше висвітлюється специфіка формування творчої особистості українського сучасного сценографа Тетяни Медвідь у контексті впливу на її особистість трьох шкіл української сценографії. Становлення Т. Медвідь, як сценографа, відбувалося в другій половині ХХ сторіччя, а її театральні проекти були створені в системі образотворчоїрежисури. Дослідження впливу сценографічних шкіл України на формування творчої особистості митця важливе як для висвітлення феномену творчості Т. Медвідь, так і для усвідомлення традицій національної школи сценографії.
ХОРЕОГРАФІЧНІ ТВОРИ ОЛЕКСІЯ ГОМОНА В РЕПЕРТУАРІ АНСАМБЛІВ НАРОДНОГО ТАНЦЮ УКРАЇНИ
Authors: Гутник Ірина
Published: May 2021

Висвітлено особливості балетмейстерської діяльності народного артиста України Олексія Гомона в контекстірозвитку народно-сценічного танцювального мистецтва України. Проаналізовано його творчий доробок –хореографічні номери в репертуарі професійних та аматорських танцювальних колективів, ансамблів пісні і танцю.Висновки про характерні особливості хореографічних творів митця та власний стиль роботи балетмейстера зробленона основі аналізу наукових праць, періодичних видань, а також спогадів колишніх артистів і колег.
ІНТЕРПРЕТАЦІЯ ЄВРОПЕЙСЬКОЇ МУЗИКИ КИТАЙСЬКИМИ СПІВАКАМИ : НІМЕЦЬКА ПІСЕННА ЛІРИКА У ВИКОНАННІ ДІЛЬБЕР ЮНУС
Authors: Лін Чжу
Published: May 2021

Розглянуто особливості сучасних версій прочитання камерно-вокальних творів європейських композиторівкитайськими співаками. Охарактеризовано передумови та шляхи формування традицій китайської вокальної школи,процеси адаптації західних моделей виконавської культури та поєднання різної специфіки музичного мислення.Розкрито принципи формування репертуарної політики китайських вокалістів. На основі аналізу пісень німецькихкомпозиторів доби раннього та пізнього романтизму «Auf Flügeln des Gesanges» Ф. Мендельсона та «MariäWiegenlied» М. Регера у виконанні видатної китайської співачки Дільбер Юнус сформульовано висновки, що впроцесі адаптації європейських зразків у китайсько-мовних версіях може порушуватись фонічний профільвокальних мініатюр, а їх зміст – насичуватись новими смислами, складаючи підґрунтя для творчогоінтерпретаційного національно-орієнтованого підходу.
ЖАНРОВО-СТИЛІСТИЧНІ ОСОБЛИВОСТІ ІНСТРУМЕНТАЛЬНОЇ ТВОРЧОСТІ ВОЛОДИМИРА ІВАСЮКА
Authors: Довгань Оксана , Мисько Галина
Published: May 2021

Стаття присвячена інструментальній спадщині всесвітньо відомого українського композитора-пісенникакінця ХХ століття В. Івасюка. Досліджено, що митець окрім пісенного плідно працював у камерно-інструментальному жанрі, характерному українським композиторам другої пол. ХХ ст. – сюїті, інструментальніймініатюрі та ін. З’ясовується, що у різноманітних оркестрових творах композитор використовував поєднання яккласичних, так і «некласичних» інструментальних складів, а для музичної мови циклічних творів, інструментальнихмініатюр, музики до театральних вистав автора характерне колористичне насичення багатством карпатськогофольклору з використанням новітніх авангардних композиторських технік та сучасних засобів музичної виразності.
ІНТЕРТЕКСТУАЛЬНІСТЬ У ДИЗАЙНІ ОДЯГУ ДРУГОЇ ПОЛОВИНИ ХХ – ПОЧАТКУ ХХІ ст.
Authors: Білякович Ліана
Published: May 2021

Охарактеризовано феномен інтертекстуальності в культурі постмодернізму. Розглянуто загальнокультурні,естетичні і художньо-проектні передумови, сутність, функції, основні типи, прийоми і засоби інтертекстуальності вдизайні одягу другої пол. ХХ – початку ХХІ ст. Визначено образотворче і формотворче значення інтертекстуальності утворчості провідних світових дизайнерів і творчо-пошукових стратегіях Будинків Мод (Yves Saint-Laurent,Gianni Versace, Gianfranco Ferre, John Galliano, Alexander McQueen, Ann Demeulemeester, Naeem Khan, GabrieleColangelo, Jeremy Scott, Світлани Тегін, Carven, Valentino, Andrew Gn), заснованих на інтеграції у дизайн одягу текстівобразотворчого та декоративно-ужиткового мистецтва, архітектури, фотографії, літератури шляхом цитування,ремінісценцій, алюзій, стилізації.
РЕТРАНСЛЯТОРИ ХУДОЖНІХ ТРАДИЦІЙ МИНУЛОГО. СПАДКОЄМНІСТЬ ПОКОЛІНЬ У ХУДОЖНІЙ ТВОРЧОСТІ. МИСТЕЦТВО КОЛАЖУ
Authors: Міронова Тетяна
Published: May 2021

Проаналізовано оновлення філософії сучасного українського мистецтва під впливом змін, що відбувались в культурно-соціальному житті країни на усіх соціальних рівнях, що зробили contemporary art самодостатнім і виразним явищем, яке оновило мистецьке бачення за допомогою комунікації з аудиторією. Зокрема вказано, щосучасне українське візуальне мистецтво перейшло до пошуків оновленої образності, перевершуючи суто естетичні функції та виходячи за рамки традиційних культурних стандартів. Це вимагає нової серії асоціацій та оновлення аналітичного інструментарію для фахівців. Так, з кінця ХХ ст. традиції, що раніше працювали в рамках «класичного» мистецького канону, розширились за рахунок оновлення тематичних, образних й часо-просторових координат, задаючи художникам вектор розвитку. Саме митці в цей час стають певними лідерами, що виявилися здатними поєднати історичні образи та новітні технології в єдиному художньому синтезі, засвідчуючи співіснування культури та часу. Вони вивели сучасне мистецтво в поле культурно-історичної пам’яті, оскільки, використовуючи «вічні образи» історії мистецтва, послуговуючись методами запозичення, цитування, діалогу та наслідування, відобразили їх у художньому процесі.
ТВОРЧІСТЬ МИТЦІВ КЛАСИЧНОГО ЮВЕЛІРНОГО ДОМУ «ЛОБОРТАС» У КОНТЕКСТІ СУЧАСНОГО ЮВЕЛІРСТВА УКРАЇНИ : ІСТОРІОГРАФІЯ
Authors: Луць Сергій
Published: May 2021

Аналізуються основні аспекти історіографії, що окреслюють еволюцію творчої діяльності Класичногоювелірного Дому «Лобортас» у контексті ювелірного мистецтва України на межі ХХ – ХХІ ст. Історіографічна картаозначеної тематики дає змогу простежити формування загальних критеріїв вектору творчості «лобортасівців»,послідовність накопичення джерельної бази та стан досліджень розвитку означеної ювелірної компанії. Системнийаналіз джерел, дотичних до даного дослідження, окреслює розширене коло суттєвих питань щодо вивченнястановлення та розвитку творчого процесу провідної української ювелірної фірми «Лобортас» у просторівітчизняного і світового ювелірного мистецтва як важливої неопрацьованої частини сучасного українськогодекоративно-прикладного мистецтва.
СУЧАСНІ ТЕАТРАЛЬНІ ФЕСТИВАЛІ М. РІВНОГО
Authors: Казначеєва Людмила , Гринчук Марина
Published: May 2021

Розглянуто найбільш помітні театральні фестивалі м. Рівне, проведені в останні роки, ініційовані Рівненськимміським Палацом дітей та молоді, зокрема «ЛіхтArt» – фестиваль студентських, навчальних, молодіжних таюнацьких театрів, «Крила» – фестиваль інклюзивної театральної творчості, «Відкрита брама» – театральна імпреза,спрямована на розвиток театральної культури м. Рівного, а також фестиваль дитячих лялькових колективів«Березневі сходинки». Окреслено форми функціонування фестивалів в умовах пандемії.
INTELLIGENT AQUACULTURE ENVIRONMENT MONITORING SYSTEM BASED ON LORA COMMUNICATION TECHNOLOGY
Authors: Huiying Cai , Fangzhen Li , Peng Lv , Lingqiang Ran , Lida Zou
Published: May 2021

In view of the nonlinearity and large time delay characteristics of the aquaculture, this paper proposes an environment monitoring system based on low long range (LoRa) communication technology. The system integrates sensor nodes, dissolved oxygen regulation node, LoRa communication network and personal computer (PC) platform to realize real-time monitoring, storage and data sharing. The environmental parameters were processed by programmable logic controller (PLC) intelligent controller, in which, the dissolved oxygen was adjusted with the variable universe fuzzy PID algorithm. The system was tested in a fish pond with an area of 110*120 square meters. The results show that the system can obtain temperature, pH and dissolved oxygen in real time and it has the advantages of high measurement accuracy, stable and reliable data transmission, and can satisfy the needs of aquaculture intelligent management.
DESIGN AND EXPERIMENT OF ADJUSTABLE SOCKET-WHEEL PRECISION FERTILIZER APPARATUS FOR DRY DIRECT-SEEDING RICE
Authors: Jun Liu , Dequan Zhu , Qilei Tai , Congyang Yu , Tingjue Wang , Kang Xue , Shun Zhang , Juan Liao
Published: May 2021

To solve problems of non-adjustable fertilizer and low fertilization precision in the precision hole fertilization of dry direct-seeding rice, an adjustable socket-wheel precision hole fertilizer apparatus for rice was designed. The basic structure and working principle of the fertilizer apparatus were expounded, the structural parameters of key components were determined. The numerical simulation experiments based on the discrete element method were carried out by using sulfurized urea as the research object. Selecting the rotation speed of the socket-wheel, the length of the trough, the depth of the socket as the experimental factors, and taking the average amount of fertilizer discharging and the coefficient of variation of fertilization uniformity as evaluation indicators, the orthogonal rotation combined experiments with three factors and five levels were carried out. A multi-objective optimization method was used to determine the best parameter combination under the constraint of the target value of the hole fertilizer discharging of 1.500 g. The simulation results show that the coefficient of variation of fertilizer uniformity was the smallest and the coefficient of variation was 15.80% when the rotation speed of socket-wheel was 26.57 r/min, the length of the trough was 5.36 mm and the depth of socket was 5.64 mm. By using slow-release urea, sulfurized urea and bio-organic fertilizer as test materials, the bench test and field test was carried out on the fertilizer apparatus and the reliability of the simulation results and the adaptability of the fertilizer apparatus were verified.
THE CONCEPT OF BUSINESS COOPERATION IN THE FORMATION OF LOGISTICS DISTRIBUTION CHANNELS
Authors: Vasylkivsky Dmytro , Shevchuk Anna
Published: May 2021

Introduction. The article is devoted to the formation of a theoretical concept about the loyalty of consumers in the distribution channels of finished products as some complex economic phenomenon.
The article addresses the problem of distribution channels and their effective formation which is one of the utmost importance at present time. The results showed that distribution channels are an important link in the value chain, which contribute to achieving a balance of interests of functionally related businesses that ensure the delivery of goods from producer to consumer. It is determined that the recent changes in the activities of wholesale and retail intermediaries are associated with changes in purchasing behavior, the development of network retail, the emergence of new forms and methods of selling goods, the active use of information technology and online interaction.
Goal. Development of conceptual provisions for business cooperation in marketing distribution channels.
Results. It is substantiated that the traditional market space, dominated by the manufacturer, is evolving and is now taking the form of what is called a market space focused on distribution. It is proved that within this space there is a shift of emphasis from competitive relations between participants of distribution channels to relations of cooperation and partnership. This requires the development of new mechanisms of interaction in such distribution channels, taking into account the economic interests of their participants and ensuring consistency of action based on the concept of business cooperation.
It is noted in the article that the need to expand the boundaries of interaction arises due to the need to increase the efficiency of enterprises through the possibility of using the skills, resources and assets of business partners. It is proved that cooperation in modern conditions becomes the basis for ideas generation, innovations development, and a source of sustainable competitive advantages that contribute to the formation of a unique strategic asset – a partnership network based on a long-term mutually beneficial relationships of business partners in the chain of created value. At the same time, the refusal to cooperate leads to differences in the interests, goals and functions of participants in marketing distribution channels, which entails conflicts and increases costs in the process of delivery of goods from producer to final consumer.
REGIONAL MARKETS OF MEDICAL SERVICES: SPECIFICS OF FORMATION AND PROVISION IN THE CONDITIONS OF MEDICAL REFORM
Authors: Zheliuk Tetiana , Chigur Olga
Published: May 2021

Introduction. The article substantiates the scientific principles of forming the market of medical services, which would meet the global challenges and needs of reforming the domestic medical industry, would take into account the trends of decentralization. The structural blocks of the market of medical services are identified and the specifics of administration of their provision in modern conditions with the use of contractual and contractual forms are analyzed.
Goal. The goal is to substantiate the essential determinants and applied aspects of the formation of the medical services market, taking into account the needs of decentralization and improving the administration of their provision through a system of agreements and contracts.
Methods. Methods of system, structural-logical, comparative analysis and generalization are used in the scientific publication.
Results. The scientific approaches to the formation of the market of medical services at the regional level are substantiated, the peculiarities of the organization of their provision through the prism of concluding agreements and contracting are verified. Emphasis is placed on the fact that regional health care markets will be the best way to improve the provision of resources for the provision of medical services, their innovation, thus improving the quality, reducing the financial risks of providing and receiving medical services, increasing the responsible attitude of the population to their health.
Conclusions. The main provisions of the scientific article will contribute to the formation of a competitive market for medical services, improve the quality of their provision and strengthen public health.
STRATEGIC DIRECTIONS OF DEVELOPMENT OF THE SOCIAL INFRASTRUCTURE OF THE MODERN CITY
Authors: Boychenko Vadim
Published: May 2021

Introduction. The article investigates the theoretical and methodological content of the use of the principles of strategic management at the municipal level. The practical results of using the principles of strategic management in the formation of a socially oriented brand of the city on the example of Mariupol are presented. The key social problems of the city, which lie in the plane of outflow of young people from the region, the obsolescence of the development of social infrastructure, low level and quality of life of the population and low level of environmental safety are identified. Key strategic directions have been formed to solve the existing problems in the social sphere.
Goal. This is the development of strategic directions and project decisions in the field of social infrastructure development in Mariupol.
Results. It is offered, as a management tool, to use the project approach in realization of the set tasks. The content and prospects of implementation of key projects of social significance in the city are revealed. The project "Youth Retention in the Donetsk Region" is designed to increase the competitiveness of the region, its attractiveness for indigenous peoples and residents of other regions, creating conditions for professional and educational realization of youth in the city. The project "Modern medical services in the city" is aimed at improving the quality of staffing, information and material support of the city’s health care system. The project "Development of human resources of the municipality" and the project "Development of human resources of the municipality" – creates conditions for the development of a modern municipal management system in the city, increasing the level of competence of employees and involving young people in city management. The project "System of processing and satisfaction of complaints of the population" is aimed at increasing the quality, transparency and customer orientation of social services provided in the city. Statistical and sociological indicators are presented, which demonstrate the effectiveness of the implementation of the project measures proposed in the study.
SYNERGY OF EDUCATION, PRACTICE AND SCIENCE IN THE CONTEXT OF ENSURING THE EFFICIENCY OF EMPLOYMENT
Authors: Kostyshyna Tetyana , Stepanova Larysa , Studenеtz Vladуslav
Published: May 2021

Introduction. In modern conditions of development of national economy educational-scientific and practical components are the most actual in formation of competitiveness of the enterprises. It is the synergistic combination of the above components that helps to increase the level of personnel management, its labor potential, ensuring the efficiency of work.
Goal of the article is to theoretically substantiate and develop practical recommendations for areas of synergistic combination of education, practice and science in the context of ensuring the effectiveness of work.
Methods. The article uses a monographic method, analysis, method of generalization of scientific approaches, method of sociological survey.
Results. The article provides a theoretical analysis of educational and scientific factors to ensure the effectiveness of labor activity. A sociological survey of students on the impact of educational factors on the effectiveness of practical activities of graduates. It is determined that a high share of the practical component in educational programs contributes to the acquisition of skills, development of professional and personal potential.
The directions of ensuring the efficiency of labor activity are developed by taking into account the organization of payment, labor motivation, improvement of labor rationing, increase of creative nature of labor and responsibility of employees for labor results.
Conclusions. The study allows to generalize scientific approaches to the synergistic combination of education, science and practice in the context of ensuring the effectiveness of work.
FORMATION OF COMPENSATION POLICY IN MODERN CONDITIONS OF NATIONAL ECONOMY DEVELOPMENT
Authors: Kostyshyna Anna
Published: May 2021

Introduction. The development of the national economy requires modern enterprises to build and implement a new compensation policy through innovative approaches to the formation of wages and incentive mechanism.
Goal is the theoretical substantiation of the essence of compensation policy and the development of directions of its formation on the basis of the organization of wages and motivational mechanism, regulation at the state and contractual levels, the level of the enterprise.
Methods. The article uses a monographic method, analysis, method of generalization of scientific approaches.
Results. The article provides a theoretical analysis of scientific thought on the interpretation of the concepts of "compensation" and "compensation policy". The author's approach to the definition of "compensation policy" is formed. The study of the essence of compensation policy allows to interpret it as an activity at different levels of government (state, industry, regional, enterprise and organization, interpersonal) to form the conditions of remuneration and motivational mechanism to achieve strategic goals of social and labor relations.
The foreign experience of the organization of the compensation system is considered. The influence of compensation policy on the competitiveness of personnel and the enterprise as a whole is determined. The directions of wage formation at the state and contractual levels as an important component of compensation policy in modern conditions of national economy development are developed.
Conclusions. The study allows to generalize scientific approaches to the concept of "compensation policy" and suggest directions for its development, which will help ensure the competitiveness of staff, enterprises, the region, the national economy as a whole.
PECULIARITIES OF LABOR POTENTIAL TRANSFORMATION IN HUMAN CAPITAL IN THE CONDENSE OF DEEPENING DEMOGRAPHIC CRISIS
Authors: Kachan Yevhen , Koshil Nataliia
Published: May 2021

Introduction. The employment potential has been steadily declining in Ukraine for the recent decades. The number of economically active population, which is the basis of labor potential has been declining, so there are concerns about the prospects of providing the national economy with living labor resources. Today, the human factor has become a priority in the system of "man-economy" and therefore the problem of labor potential formation and its transformation into human capital has become especially relevant. Considering the labor potential as an opportunity for the economically active population to provide the national economy with living labor resources, the nature of demographic and migration processes in the country and in particular in most regions is a matter of concern. As a result of these processes, there is an undesirable for the society, deterioration of the quality structure of labor potential: the working age population is reduced, there is an increase in emigration, especially of young people, for favorable employment and training. In recent years, there is no simple reproduction of labor potential. The number of people retiring is higher than the number of those entering working age. Existing trends in the reproduction of labor potential, especially the process of depopulation, in the near future require increased investment in the economically active population and the introduction of labor-saving technologies is the main direction to prevent labor shortages.
Goal. To pay attention of scientists and specialists to the need to deepen research on the peculiarities of human capital formation in the regions, taking into account the demographic situation and trends in the development of their labor potential.
Results. Considering the labor potential as a natural basis of human capital, the authors conclude that in a demographic crisis, investment in human resources is the key to economic growth and overcoming labor shortages, strengthening the human resources of society.
To draw the attention of scientists and specialists to the need to deepen research into the features of the formation of human capital in the regions, taking into account the demographic situation and trends in the development of their labor potential.
The article considers methodological approaches to the economic evaluation of human capital, methodological approaches for calculating the human capital index are proposed. Areas of targeted investment in labor potential to ensure its expanded reproduction are proposed.
SINERGI STAKEHOLDER DALAM MENANGANI ANCAMAN PENYELUNDUPAN NARKOBA DI PROVINSI ACEH
Authors: Hartanto Dhimas Rudy , Anak Ampun Artha C. Rosevina , Dachi Endyka Triono , Wiranto Surya , Madjid M. Adnan
Published: May 2021

Narkotika merupakan suatu zat yang sangat berbahaya apabila dikonsumsi oleh tubuh. Salah satu wilayah yang terkena dampak penyebaran narkotika adalah Provinsi Aceh. Transaksi penyelundupan narkoba dilakukan melalui jalur laut dengan pemindahan narkotika dari satu kapal ke kapal yang lain. Badan Narkotika Nasional Provinsi (BNNP) Aceh mempunyai tugas untuk mencegah, memberantas penyalahgunaan dan peredaran gelap narkotika. Hasil dalam penelitian ini bahwa strategi BNNP Aceh dalam menghentikan penyelundupan narkoba dengan pengalaman penangkapan terhadap bandar cukup berat karena pelaku menggunakan teknologi informasi yang canggih. Tindakan penyelundupan narkoba melalui laut yakni terjadi kerjasama antara pihak penyelundup dengan nelayan. Kegiatan penindakan dan rehabilitasi serta kegiatan pencegahan sudah dilakukan melalui publik visual, media sosial, dan lain-lain. Pemerintah sudah melakukan koordinasi dengan negara-negara tetangga mengingat bahwa penyelundupan narkoba sudah dapat disebut sebagai perang proxy. Peredaran narkoba melalui jalur laut merupakan ancaman serius yang harus dihadapi dengan sungguh-sungguh. BNN juga bersinergi dengan Badan Keamanan Laut serta Bea Cukai untuk bersama-sama membentengi laut Indonesia dari serbuan narkoba. Beberapa instansi seperti Tuha Peut, Tuha Lapan, dan Panglima Laot dirangkul dengan baik untuk membantu proses pengedaran narkoba di Aceh.
IMPLEMENTASI KEBIJAKAN VAKSINASI COVID-19 DI KOTA SURABAYA
Authors: Asyafin Muhammad Akbar , Virdani Diaz , Kasih Kiki Darma , Arif Lukman
Published: May 2021

The purpose of this study is to describe implementation of COVID-19 vaccination policy, to find supporting and inhibitings factors or efforts to overcomes them in Surabaya city. Theoretical approach used is the George C. Edward III policy implementation approach. Thiss research use qualiitative methods with a descriptives approach. Data collection carried out through observatiion and interviews. Analysis data techniques in this reseacrh consisted of data collections, data condensations, data presentations, and drawing conclusions according to Miles-Huberman model. Results show that  implementation of COVID-19 vaccination policy in the City of Surabaya in fact found a number of problems in implementation of the COVID-19 vaccination on Surabaya, including realization  vaccines to targets far from the target set, the reluctance of potential vaccine recipients to inform the cause of their absence to health facility officers, less the active target group of potential vaccine recipients to come according to the set schedule. Another cause that is no less important is the lack of synchronization of data on potential vaccine recipients obtained by health facilities as administrators, because some of the data entered are potential vaccine recipients who are survivors, some were even founds to have vaccinated elsewhere. So, socialization from the local government regarding implementation of COVID-19 vaccination policy in Surabaya City important and provides education. Therefore, researchers suggest that there be improvements and synchronization of data on potential vaccine recipients, so that vaccine recipients are well monitored and integrated.
URIC ACID LEVEL AS A PREDICTOR OF SEVERITY IN PREGNANT WOMEN WITH SEVERE PREECLAMPSIA
Authors: Natasya Natasya , Siregar Fidel Ganis , Ganie Ratna Akbari
Published: May 2021

Preeclampsia is a pregnancy syndrome affecting multiple
organ systems, characterized by hypertension and
proteinuria after 20 weeks of gestation. The incidence of
preeclampsia is estimated to be 3-10% of pregnancies
worldwide and is the leading cause of death for pregnant
women. Preeclampsia is a life-threatening obstetric
emergency, so it needs prompt and precise treatment to
prevent morbidity and mortality. WHO estimates that the
incidence of preeclampsia is seven times higher in developing
countries (2.8% of live births) than in developed countries
1,2 (0.4%).
CHANGING METHODS & PATTERNS OF STUDY AMONG MEDICAL UNDERGRADUATES
Authors: Arish Ezhava , Gawand Rushikesh , Adkar Rohan , Mane Nilesh , Mhase Pooja , Rasal Rutuja
Published: May 2021

Background: This article examines study patterns among medical undergraduates. Material & Method:
A cross sectional study was carried out in 600 students of Rural Medical College, Loni. Stratied random
Sampling method was used to select randomly select 50 boys and girls among (I, II, III, III/II and Interns) respectively. Written
informed consent was taken. A semi structured questionnaire was developed and lled by the students. Descriptive statistical
analysis was done using percentage values. Correlation and strength of association was determined by spearman's rank
correlation. Results: Majority, 456 (76%) students felt they retained audio-visual data better than reading textbooks. COVID
pandemic may also alter their study habits in short term as well as long term. Conclusion: Changing trends in how students
prefer to study need to be taken into account while teaching them. Not all trends are positive. Habits like frequent phone
browsing and reliance on unveried online study material must be discouraged.