bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics
Authors: Sulaimani Md Nayab , Ahmed Shazia , Anjum Farah , Mohammad Taj , Shamsi Anas , Dohare Ravins , Hassan Md. Imtaiyaz
Published: January 2025

Mitogen-activated protein kinase 1 (MAPK1) is a serine/threonine kinase that plays a crucial role in the MAP kinase signaling transduction pathway. This pathway plays a crucial role in various cellular processes, including cell proliferation, differentiation, adhesion, migration, and survival. Besides, many chemotherapeutic drugs targeting the MAPK pathway are used in clinical practice, and novel inhibitors of MAPK1 with improved specificity and efficacy are required. Hence, targeting MAPK1 can be crucial to control metastasis in cancer therapeutics. In this study, we utilized a structure-guided virtual screening approach to screen a library of thousands of natural compounds from the ZINC database. The Lipinski rule of five (RO5) was used as a criterion for the primary selection of natural compounds. The screened compounds were prioritized based on their binding affinity, docking scores, and specificity towards the kinase domain of MAPK1 during the molecular docking process. Subsequently, the selected hits underwent rigorous screening that included the identification of potential pan-assay interference compounds (PAINS), ADMET evaluation, and prediction of pharmacological activities using PASS analysis. Afterwards, we performed a comprehensive interaction analysis to explore the binding prototypes of the screened molecules with the key residues within the MAPK1 kinase domain. Finally, selected molecules underwent extensive all-atom molecular dynamics (MD) simulations for a time duration of 200 nanoseconds. The study pinpointed three natural compounds with ZINC database IDs ZINC0209285, ZINC02130647, and ZINC02133691 as potential inhibitors of MAPK1. The study highlights that these compounds could be explored further in preclinical and clinical investigations to develop anticancer therapeutics.
Pedestrian POSE estimation using multi-branched deep learning pose net
Authors: Shahid Muhammad Alyas , Raza Mudassar , Sharif Muhammad , Alshenaifi Reem , Kadry Seifedine
Published: January 2025

In human activity-recognition scenarios, including head and entire body pose and orientations, recognizing the pose and direction of a pedestrian is considered a complex problem. A person may be traveling in one sideway while focusing his attention on another side. It is occasionally desirable to analyze such orientation estimates using computer-vision tools for automated analysis of pedestrian behavior and intention. This article uses a deep-learning method to demonstrate the pedestrian full-body pose estimation approach. A deep-learning-based pre-trained supervised model multi-branched deep learning pose net (MBDLP-Net) is proposed for estimation and classification. For full-body pose and orientation estimation, three independent datasets, an extensive dataset for body orientation (BDBO), PKU-Reid, and TUD Multiview Pedestrians, are used. Independently, the proposed technique is trained on dataset CIFAR-100 with 100 classes. The proposed approach is meticulously tested using publicly accessible BDBO, PKU-Reid, and TUD datasets. The results show that the mean accuracy for full-body pose estimation with BDBO and PKU-Reid is 0.95%, and with TUD multiview pedestrians is 0.97%. The performance results show that the proposed technique efficiently distinguishes full-body poses and orientations in various configurations. The efficacy of the provided approach is compared with existing pretrained, robust, and state-of-the-art methodologies, providing a comprehensive understanding of its advantages.
Analysis of seroprevalence and risk factors for syphilis and HIV among female sex workers and transgender individuals in different cities of Sindh, Pakistan
Authors: Shah Sharaf A. , Zubair Maria , Soomro Altaf , Sheikh Rasheed , Zhamalbekova Alnara , Abidi Syed Hani
Published: January 2025

Introduction

Co-infections of syphilis and HIV have been found to exacerbate the impact on sexual and reproductive health, especially among key population groups such as Female Sex Workers (FSWs) and Transgender Individuals (TGs). The data on the prevalence and determinants of syphilis and HIV in Pakistan, particularly in Sindh province, is limited. This prospective cross-sectional study aimed to determine the seroprevalence and risk factors for HIV and syphilis infections among FSWs and TGs in different cities of Sindh, Pakistan.

Methods

A total of 1120 participants (531 FSWs and 589 TGs) were recruited from Karachi, Sukkur, Hyderabad, and Larkana. Community-based serological testing for HIV and syphilis was performed using Abbot Bioline HIV/syphilis Duo test kits, and sociodemographic and risk factor data were collected through questionnaires. Chi-square and logic regression were applied to determine variables associated significantly with syphilis in TGs and FSWs.

Results

TGs exhibited higher rates of syphilis (16.29%) and syphilis-HIV (6.79%) as compared to FSWs (syphilis: 15.63%; syphilis-HIV: 0.75%). Inconsistent condom use was more common among FSWs (75.32%), and over half reported STI symptoms. Regression analysis showed that for TGs, having five years (adjusted OR: 0.52, p = 0.04) and graduate-level education (adjusted OR: 0.40, p = 0.04) was associated with a lower risk of syphilis, while an income between 30,000 and 50,000 Pakistani rupees (OR: 1.93, p = 0.028) and more than three years in profession (adjusted OR: 2.20, p = 0.04) was associated with a higher risk. For FSWs, five (OR: 0.34, p = 0.03) and ten (OR: 0.02, p = 0.02) years of education were associated with a lower risk of syphilis, whereas an income between 30,000 and 50,000 PKR (OR: 3.05, p < 0.01) and self-reported HIV-negative status (OR: 3.08, p = 0.01) were associated with a higher risk of syphilis mono-infection.

Conclusion

In conclusion, the results of the study show higher rates of syphilis and HIV co-infection among TG compared to FSW from Sind. The study findings provide valuable insights for national health agencies and policymakers to devise data-driven strategies for preventing and controlling syphilis and HIV infections among FSW and TG populations in Sind.
An infodemiologic review of internet resources on dental hypersensitivity: A quality and readability assessment
Authors: Alassaf Muath Saad , Bakkari Ayman , Saleh Jehad , Habeeb Abdulsamad , Aljuhani Bashaer Fahad , Qazali Ahmad A. , Alqutaibi Ahmed Yaseen
Published: January 2025

Background

This study aimed to investigate the quality and readability of online English health information about dental sensitivity and how patients evaluate and utilize these web-based information.

Methods

The credibility and readability of health information was obtained from three search engines. We conducted searches in "incognito" mode to reduce the possibility of biases. Quality assessment utilized JAMA benchmarks, the DISCERN tool, and HONcode. Readability was analyzed using the SMOG, FRE, and FKGL indices.

Results

Out of 600 websites, 90 were included, with 62.2% affiliated with dental or medical centers, among these websites, 80% exclusively related to dental implant treatments. Regarding JAMA benchmarks, currency was the most commonly achieved and 87.8% of websites fell into the "moderate quality" category. Word and sentence counts ranged widely with a mean of 815.7 (±435.4) and 60.2 (±33.3), respectively. FKGL averaging 8.6 (±1.6), SMOG scores averaging 7.6 (±1.1), and FRE scale showed a mean of 58.28 (±9.1), with "fair difficult" being the most common category.

Conclusion

The overall evaluation using DISCERN indicated a moderate quality level, with a notable absence of referencing. JAMA benchmarks revealed a general non-adherence among websites, as none of the websites met all of the four criteria. Only one website was HON code certified, suggesting a lack of reliable sources for web-based health information accuracy. Readability assessments showed varying results, with the majority being "fair difficult". Although readability did not significantly differ across affiliations, a wide range of the number of words and sentences count was observed between them.
Analysis of spatiotemporal distribution, variability, and trends of rainfall in Wollo area, Northeastern Ethiopia
Authors: Adane Asnake , Asmerom Birhanu
Published: January 2025

Ethiopia’s agriculture is mostly dependent on rain, though the rainfall distribution and amount are varied in spatiotemporal context. The study was conducted to analyze the distribution, trends, and variability of monthly, seasonal, and annual rainfall data over the Wollo area from 1981 to 2022. To accomplish this, the study utilized the Climate Hazards Group Infrared Precipitation with Stations version two (CHIRPS-v2) data. Standard Rainfall Anomaly Index (SRA) and Coefficient of Variation (CV) were employed to examine rainfall variability and develop drought indices over southern Ethiopia. The Modified Mann Kendall (MMK) test, Sen’s slope estimator and the innovative trend analysis (ITA) were employed to detect temporal changes in rainfall trends over the study period. The study found that the area experienced considerable rainfall variability and change, resulting in extended drought and flood events within the study period. Results from SRA and CV revealed interannual and seasonal rainfall variability, with the proportions of years below and above the long-term mean being estimated at 56% and 44%, respectively. The MMK test showed that the annual rainfall during the Kiremt (summer-main rainy season) had an increasing trend. On the other hand, rainfall for the Belg (short rain season for the study area) season and the Bega (winter) season showed a significantly decreasing trend (p < 0.05). Results from the innovative trend analysis (ITA) also revealed that the annual and seasonal rainfall trends exhibited different trends in varied magnitude for different stations. On a spatial basis, the eastern and northeastern regions of the study area showed trends of increasing rainfall during the Kiremt (JJA). Decision-makers and development planners need to design strategies to mitigate the risks posed by changes in rainfall variability and distribution and enhance community adaptation and mitigation capacities in Wollo, Ethiopia.
The impact of climate change on Korea’s agricultural sector under the national self-sufficiency policy
Authors: Kim Seulki , Eom Jiyong , Zhang Ying , Waldhoff Stephanie
Published: January 2025

Evolving environmental conditions due to climate change have brought about changes in agriculture, which is required for human life as both a source of food and income. International trade can act as a buffer against potential negative impacts of climate change on crop yields, but recent years have seen breakdowns in global trade, including export bans to improve domestic food security. For countries that rely heavily on imported food, governments may institute policies to protect their agricultural industry from changes in climate-induced crop yield changes and other countries’ potential trade restrictions. This study assesses the individual and combined effects of climate impacts and food self-sufficiency policies in Korea, which is highly dependent on imports. We use the Global Change Analysis Model (GCAM), a global integrated assessment model, to explore (1) the direct impact of climate change on Korea’s agricultural yields, (2) the full impacts of global climate change on agricultural production, including trade-induced changes due to yield changes in other regions, (3) the impacts of food self-sufficiency policy, and (4) the interactive impact of climate change and self-sufficiency policies. We find that, in Korea, the direct impact of climate change on agricultural yields would be overshadowed by the impact of global climate change due to changing trade patterns. Second, global climate change leads to a rise (rice and wheat) or a decline (soybeans) in Korean producer revenues, while simultaneously raising consumer expenditures on both staples and non-staples. Third, implementing self-sufficiency policies for wheat and soybeans in Korea boosts the nation’s producer revenues, in conjunction with the effects of climate change, at the cost of additional increases in consumer expenditures for both staples and non-staples.
Radar versus optical: The impact of cloud cover when mapping seasonal surface water for health applications in monsoon-affected India
Authors: Uday Gowri , Purse Bethan V. , Kelley Douglas I. , Vanak Abi , Samrat Abhishek , Chaudhary Anusha , Rahman Mujeeb , Gerard France F.
Published: January 2025

Surface water plays a vital role in the spread of infectious diseases. Information on the spatial and temporal dynamics of surface water availability is thus critical to understanding, monitoring and forecasting disease outbreaks. Before the launch of Sentinel-1 Synthetic Aperture Radar (SAR) missions, surface water availability has been captured at various spatial scales through approaches based on optical remote sensing data. A critical drawback of the latter is data loss due to cloud cover, however few studies have quantified this. This study evaluated data loss due to clouds in three Western Ghats (India) districts. These forest-agricultural mosaic landscapes, where water-related diseases are prevalent, experience the Indian monsoon. We compared surface water areas mapped by thresholding 10m Sentinel-1A SAR data with the optical 30m Landsat-derived Joint Research Centre (JRC) Global Surface Water product, currently the only globally available long-term monthly surface water data product. Backscatter thresholds were identified manually, and our Bayesian algorithm found these thresholds were very likely (>97%). While the Sentinel-1 SAR-based and JRC’s optical-based approach mapped surface water extent with high overall accuracy (> 98%) when the cloud cover was low, the unmapped surface water area was substantial in the JRC product during the monsoon months. Across the districts, the average cloud cover in the July-August period was 92% or 90% for 2017 and 2018 respectively, resulting in 25% or 23% of the surface water area being unmapped. Also, the more detailed 10m resolution of Sentinel-1A SAR helped detect the many small water features missed by 30m JRC. Thus, for predicting water-related disease risks linked to small water features or monsoon rainfall, Sentinel-1A SAR is more effective. Finally, automatic backscatter thresholding for unvegetated surface water mapping can be effective if threshold values are adapted to regional-specific backscatter spatial and temporal variations.
Weight trajectories in aging humanized APOE mice with translational validity to human Alzheimer’s risk population: A retrospective analysis
Authors: Vitali Francesca , Wiegand Jean-Paul , Parker-Halstead Lillian , Tucker Allan , Diaz Brinton Roberta
Published: January 2025

Translational validity of mouse models of Alzheimer’s disease (AD) is variable. Because change in weight is a well-documented precursor of AD, we investigated whether diversity of human AD risk weight phenotypes was evident in a longitudinally characterized cohort of 1,196 female and male humanized APOE (hAPOE) mice, monitored up to 28 months of age which is equivalent to 81 human years. Autoregressive Hidden Markov Model (AHMM) incorporating age, sex, and APOE genotype was employed to identify emergent weight trajectories and phenotypes. In the hAPOE-AD mouse cohort, five distinct weight trajectories emerged: three trajectories were associated with a weight loss phenotype (36% of mice, n = 426), one with weight gain (13% of mice, n = 152), and one trajectory of no change in weight (34% of mice, n = 403). The AHMM model findings were validated with post-hoc survival analyses, revealing differences in survival rates across the five identified phenotypes. Further validation was performed using body composition and plasma β-amyloid data from mice within the identified gain, loss and stable weight trajectories. Weight gain trajectory was associated with elevated plasma β-amyloid levels, higher body fat composition, lower survival rates and a greater proportion of APOE4/4 carriers. In contrast, weight loss was associated with greater proportion of hAPOE3/4 carriers, better survival rates and was predominantly male. The association between weight change and AD risk observed in humans was mirrored in the hAPOE-AD mouse model. Weight trajectories of APOE3/3 mice were equally distributed across weight gain, loss and stability. Surprisingly, despite genetic uniformity, comparable housing, diet and handling, distinct weight trajectories and divergence points emerged for subpopulations. These data are consistent with the heterogeneity observed in the human population for change in body weight during aging and highlight the importance of longitudinal phenotypic characterization of mouse aging to advance the translational validity of preclinical AD mouse models.
Incidence and predictors of mortality among HIV positive children on anti-retroviral therapy in the selected health facilities of West Wollega Zone, Western Ethiopia: Retrospective cohort study
Authors: Gurmu Gelane , Merdassa Emiru , Tiruneh Gemechu , Efrem Keneni , Belay Firezer , Mekonnen Lalisa , Feyisa Jira Wakoya , Lema Matiyos , Shama Adisu Tafari , Desalegn Markos
Published: January 2025

Introduction

The mortality rate among Human immunodeficiency Virus (HIV) who have started antiretroviral therapy (ART) continues to be increased in resource-limited countries, despite a decline in developed nations. Furthermore, research within this age group is limited and has not previously been conducted in the study area. Consequently, this study aimed to determine the incidence of mortality and its predictors among HIV-positive children who have been receiving ART at public health facilities in West Wollega.

Objective

To assess incidence rate and predictors of mortality among HIV-positive children on ART at selected health facilities of West Wollega, Ethiopia, 2022.

Methods

A retrospective cohort study design was conducted. A simple random sampling method was employed to select 286 children living with HIV who started ART from 01 January 2012 to 31 October 2021. Data were entered into Epi-Data Version 3.1, and STATA Version 14 was used for statistical analysis. A Kaplan-Meir survival curve and Long Rank test were used to estimate survival probability and assess statistical differences. The Cox regression model was used to determine independent predictors of mortality.

Results

The total follow-up time was 15, 652 child-months, and the overall incidence of mortality was 1.92 (95%CI: 1.34, 2.74) per 1000 child-months. The median time to death following the initiation of ART was 6 months. This study also showed that children with WHO clinical stage III (AHR = 3.4, 95% CI: 1.2, 7.4), stage IV (AHR = 5.4, 95%CI: 1.5, 19.8), Being anemic (AHR = 4.9, 95%CI: 1.8, 13.4), CD4 cell count below threshold (AHR = 3.7, 95%CI = 1.4, 9.5), delayed developmental milestone (AHR = 4.5, 95%CI: 1.7, 11.7) were at higher risk of mortality.

Conclusion

The overall mortality rate was lower compared to the previous study findings. Anemia, WHO clinical stage, CD4 cell count, and delayed developmental milestones were independent predictors of mortality. Therefore, the focus should be given to all children on ART during the early periods of ART initiation, advanced HIV disease, presence of anemia, severe immune deficiency, and delayed developmental milestones.
Empowering drones in vehicular network through fog computing and blockchain technology
Authors: Wadhwa Shivani , Gupta Divya , Rani Shalli , Driss Maha , Boulila Wadii
Published: January 2025

The performance of drones, especially for time-sensitive tasks, is critical in various applications. Fog nodes strategically placed near IoT devices serve as computational resources for drones, ensuring quick service responses for deadline-driven tasks. However, the limited battery capacity of drones poses a challenge, necessitating energy-efficient Internet of Drones (IoD) systems. Despite the increasing demand for drone flying automation, there is a significant absence of a comprehensive drone network service architecture tailored for secure and efficient operations of drones. This research paper addresses this gap by proposing a safe, reliable, and real-time drone network service architecture, emphasizing collaboration with fog computing. The contribution includes a systematic architecture design and integration of blockchain technology for secure data storage. Fog computing was introduced for the Drone with Blockchain Technology (FCDBT) model, where drones collaborate to process IoT data efficiently. The proposed algorithm dynamically plans drone trajectories and optimizes computation offloading. Results from simulations demonstrate the effectiveness of the proposed architecture, showcasing reduced average response latency and improved throughput, particularly when accessing resources from fog nodes. Furthermore, the model evaluates blockchain consensus algorithms (PoW, PoS, DAG) and recommends DAG for superior performance in handling IoT data. Fog; Drones; Blockchain; PSO; IoT; Vehicular.
Parametric modeling of under-5 children survival among 30 African countries: Lognormal accelerated failure time gamma shared frailty model
Authors: Liyew Bikis , Tesfa Kemal , Altaye Kassaye Demeke , Gelaw Abeje Diress , Bicha Alemu Teshale , Mamo Ayanaw Guade , Adane Kassaw Chekole
Published: January 2025

Background

Under-five mortality continues to be a serious public health concern in low-and middle-income countries, particularly in Africa. This study investigates the probability of under-five survival and its predictors of mortality in the African continent using a recent demographic health survey from 2014–2022.

Methods

This study utilized recent Demographic and Health Survey data from 30 African countries, encompassing 226,862 live births. This study employed a multivariable lognormal accelerated failure time gamma shared frailty parametric survival regression analysis to identify the predictors of time-to-death among under-five children in these African nations.

Result

The overall under-five child mortality rate in Africa was 37.55 per 1,000 live births (95% CI: 37.35, 37.74. In this study, children born in Western Africa; children born in Eastern Africa; children born to mothers aged 15–19 years; maternal educational status; maternal decision autonomy; being female; place of delivery; number of ANC visits; children born among mothers who delivered by Cesarean section; mothers who have multiple birth outcome; children who were second birth order; and third birth order and third birth order; children who were small in size at birth; children who were born from a community with a low women education; having poor wealth index; respondents working; mothers delivered at the age between 20–35 were significant predictors of survival time to event of under-five children in Africa.

Conclusion

This study found that the overall under-five mortality rates remain high across Africa. In this study country region, maternal age, maternal education status, maternal age at first birth, respondent’s employment status, birth outcome, wealth index, birth order, place of delivery, mode of delivery, women’s autonomy in healthcare decision-making, number of antenatal care visits, child’s size at birth, sex of the neonate, and community-level women’s education were found to be significant predictors of survival time to death of under-five children. Addressing these multilevel factors is crucial for developing targeted interventions to reduce under-five mortality further and improve child survival in African countries.
MiRNA-223-5p inhibits hypoxia-induced apoptosis of BMSCs and promotes repair in Legg-Calvé-Perthes disease by targeting CHAC2 and activating the Wnt/β-catenin signaling pathway
Authors: Yang Jiafei , Zhang Tianjiu , Zhu Xingtao , He Zhexi , Jiang Xu , Yu Song , Gu Huajian
Published: January 2025

Legg-Calvé-Perthes disease (LCPD) involves femoral head osteonecrosis caused by disrupted blood supply, leading to joint deformity and early osteoarthritis. This study investigates the role of miRNA-223-5p in regulating hypoxia-induced apoptosis and enhancing osteogenesis in bone marrow mesenchymal stem cells (BMSCs). Utilizing a juvenile New Zealand white rabbit model of LCPD established through femoral neck ligation, we transfected BMSCs with miR-223-5p mimics, inhibitors, and controls, followed by hypoxic exposure. The impact of miR-223-5p on BMSC apoptosis was assessed using qPCR, Western blotting, and dual-luciferase reporter assays, focusing on the Wnt/β-catenin signaling pathway. In vivo, we evaluated the effects of transplanting miR-223-5p-overexpressing BMSCs into the LCPD model. Our results indicate that miR-223-5p is downregulated under hypoxic conditions. Overexpression of miR-223-5p in BMSCs inhibited hypoxia-induced apoptosis and activated the Wnt/β-catenin pathway by directly targeting CHAC2. In vivo, miR-223-5p-overexpressing BMSCs enhanced femoral head osteogenesis and reduced necrosis in the LCPD model. These findings suggest that miR-223-5p inhibits hypoxia-induced apoptosis in BMSCs by targeting CHAC2 and activating the Wnt/β-catenin pathway, proposing miR-223-5p as a promising target for improving bone repair in ischemic conditions.
Time efficiency as a mediator between institutional support and higher education student engagement during e-learning
Authors: Alwerthan Tarik Abdulkrem
Published: January 2025

This study examined the relationship between institutional support and student engagement in e-learning, with time efficiency as a potential mediator among Saudi university students. This study employed a cross-sectional, questionnaire-based research design. A sample of 752 Saudi university students from different provinces in the Kingdom of Saudi Arabia completed an online questionnaire. The results of the measurement model showed good reliability and validity for all constructs. The results of the structural model and hypothesis testing showed that this study partially supported the hypotheses. Notably, there was a significant positive relationship between student support during e-learning and student engagement. In addition, student support was found to be a predictor of student’s time efficiency (short-term planning, long-term planning, time attitude). Furthermore, the results revealed that long-term planning and time attitude, both components of time efficiency, act as mediators between support provided to students by a higher education (HE) institution during e-learning and their level of engagement. The findings shed light on the underlying mechanisms that explain students’ e-learning engagement.
A study on the monitoring of LNAPL migration using ERT
Authors: Suo Kui , Zhao Mingdong , Liu Yu , Liu Hongwei , Jia Menghan
Published: January 2025

This study employs electrical resistivity tomography (ERT) to experimentally investigate the migration characteristics of light non-aqueous phase liquids (LNAPL) under various groundwater conditions. Through cross-hole measurements and time-lapse inversion, the migration process of LNAPL under three scenarios—unsaturated conditions, constant groundwater levels, and declining water levels—was systematically analyzed. The results indicate that LNAPL migration behavior exhibits significant differences under different conditions. Under unsaturated conditions, the vertical migration rate of LNAPL gradually decreases over time, with an average rate of 1.06 cm/h, and is influenced by preferential migration pathways formed in coarse-grained regions. At constant water levels, the migration of LNAPL is significantly constrained by the groundwater level, spreading horizontally near the water table after reaching it, with an average rate of 0.51 cm/h. When the groundwater level declines, LNAPL migrates rapidly downward along preferential flow paths, with an average rate increasing to 1.45 cm/h. Miller Soil Box experiments further reveal the relationship between LNAPL content and electrical resistivity, showing that an increase in LNAPL can significantly alter soil resistivity, especially under low moisture conditions. Overall, this study confirms the monitoring advantages of ERT technology for LNAPL migration behavior under different conditions and provides important references for remediation strategies at contaminated sites.
Factors contributing to visual intrapartum cardiotocograph interpretation variation among healthcare professionals: An integrative review
Authors: Lukhele Sanele , Mulaudzi Fhumulani Mavis , Gundo Rodwell
Published: January 2025

The reliability of cardiotocographs as diagnostic tools for fetal well-being is hampered by interpretational variations among healthcare professionals, contributing to high rates of cesarean sections and instrumental deliveries. While adjunct technologies may be used to confirm cases of fetal distress, those in resource constrained areas continue to rely on visual cardiotocograph interpretation to come up with the diagnosis of fetal hypoxia. This study investigated the factors contributing to variations in the visual interpretation of intrapartum cardiotocograph among healthcare professionals in the absence of adjunctive technologies. In this integrative literature review, we conducted a literature search of the following electronic databases: EBScohost, PubMed, Web of Science, and Scopus. The following search terms and Boolean operators were used: (Intrapartum OR Labor OR Labour OR Childbirth OR Birth OR Delivery) AND (Cardiotocography OR CTG OR "Electronic Fetal Monitoring" OR EFM) AND (Interpretation OR Analysis) AND (Variations OR Differences) AND (“Healthcare Workers” OR Nurses OR “Medical Workers” OR “Healthcare Professionals” OR Midwives OR Obstetricians). After removal of duplicates, a total of 1481 articles and titles were screened, 60 full-text articles were examined to verify whether they addressed the scope of the literature review. Nine articles addressed the factors contributing to variations in the visual interpretation of intrapartum cardiotocographs among healthcare professionals. The quality of the studies was appraised using the Quality Appraisal Tool for Studies of Diagnostic Reliability. Thematic analysis identified the following themes: 1) Interpretational variations in cardiotocograph characteristics among health professionals, and 2) factors leading to increased interpretational variation among healthcare professionals. Our results highlight the need for increased cardiotocograph training to improve consistency among health professionals, especially for suspicious and pathological traces, which often lead to cesarean section.
Multiparameter analysis of small non-flying mammals’ response to forest restoration post-bauxite mining in eastern Amazonia
Authors: Celeste Halícia , Almeida-Maués Paula Cristina Rodrigues , Bezerra Alexandra Maria Ramos , Lopes Maria Aparecida , Martins Marlúcia Bonifácio , Mendes-Oliveira Ana Cristina
Published: January 2025

Bauxite mining has been caused severe changes in the natural ecosystems of the Amazon, but the restoration of these areas is mandatory by federal law in Brazil. The recolonization of fauna is crucial to establishing the ecological functions of recovering forests, and the small nonflying mammals can stand out in this process. Assessing taxonomic and functional diversity parameters, we demonstrated that in the early stages of forest recovery post-bauxite mining, between 6 and 11 years, it is possible to restore approximately 45% of the richness of small non-flying mammal species from the original habitats, that in this case were altered Primary Forests. However, the species richness parameter alone does not reflect the recovery of taxonomic or functional diversity at this stage of forest succession. Although 34.8% of the species composition is shared between the Altered Primary Forest and Forest Areas in Restoration, the abundance distribution per species is less balanced in the latter habitat. The areas did not exhibit significant difference between the functional divergence and functional evenness of ecological functions performed by small nonflying mammals; however, they present differences in terms of the functional richness. We also observed that some functional traits of species, such as larger body mass, are more closely related to the structural characteristics of the Primary Forest, such as high basal area values, litter and percentage forest cover. In the forest recovery areas, we observed a predominance of terrestrial species and those with granivorous and insectivorous diets. Furthermore, our results highlight the importance of applying different taxonomic and functional diversity parameters to understand better the fauna recovery patterns in degraded areas undergoing restoration.
How is maternal employment associated with infant and young child feeding in Bangladesh? A systematic literature review and meta-analysis
Authors: Rifat M. A. , Sarkar Plabon , Rimu Israth Jahan , Alam Syeda Saima , Ara Tasnu , Battle Tobias Lindström , Kader Manzur , Saha Sanjib
Published: January 2025

Background

In the last three decades, the increasing trend in female employment in Bangladesh has been critically analyzed from a socioeconomic point of view; however, its impact on infant and young child feeding (IYCF) practices has yet to be systematically reviewed. The aim of this systematic review and meta-analysis is to investigate the association between these variables.

Methods

A systematic literature search was conducted in PubMed, Medline, Web of Science, Embase, CINAHL, and Google Scholar to retrieve relevant records with no restriction of publication period. The Covidence tool was used for screening and data extraction. Meta-analysis was carried out using random effect models. The Newcastle-Ottawa scale was used for the quality assessment of the included articles.

Results

A total of 24 articles were included. Of these, 16 focused on breastfeeding-related indicators, 6 focused on complementary feeding-related indicators, and 2 focused on both. Maternal employment was found to have both positive (protective) and negative (detrimental) associations with exclusive breastfeeding, whereas it was mainly positively associated with complementary feeding practices. Meta-analysis showed the pooled odds ratio of recommended early initiation of breastfeeding, exclusive breastfeeding, and complementary feeding among employed mothers were 0.79 (95% CI: 0.49, 1.27; p = 0.33), 0.32 (95% CI:0.16, 0.67; p = 0.002), and 1.07 (95% CI: 0.81, 1.42; p = 0.63) compared to their counterparts, respectively.

Conclusions

Maternal employment appears not to be a protective factor for some important breastfeeding indicators in Bangladesh. For example, there was a statistically significant lower likelihood of exclusive breastfeeding practice among employed mothers as compared to those who were not employed. Therefore, these issues should be taken into consideration when formulating relevant policies and interventions, e.g., breastfeeding-friendly workplace.
Realist evaluation of the AKU-SONAM mentorship program
Authors: Rehman Rehana , Javaid Quratulain , Khalid Saira , Ali Tazeen Saeed , Ali Rahila
Published: January 2025

Background & objectives

The context, mechanism, and outcome (CMO) framework is meant to identify specific contextual factors (C) related to organizational and program structure that trigger certain mechanisms (M) involving the unique characteristics of a program, leading to specific outcomes (O). The purpose of this study was to explore the contextual underpinnings, operational processes, and resultant effects of the faculty mentorship program at AKU-SONAM. This exploration involved the context in terms of organizational culture, mechanisms examining processes such as communication between mentors and mentees, quality of relationships, the challenges encountered, and the program’s adaptability to cope up while, outcomes encompassed improvements in interpersonal relationships, career advancement, and skill development.

Methods

A qualitative exploratory study was conducted at AKU-SONAM, involving in-depth interviews (IDIs) with program leadership and administrators, as well as focus group discussions (FGDs) with mentors and mentees. A semi-structured interview guide, comprising open-ended, introductory, probing, and concluding questions, was developed, validated, and reviewed by experts to ensure its effectiveness and relevance. The process included transcription of interviews, verification through member checks, and thematic analysis where codes and categories were identified and themes, were developed guided by the CMO (Context-Mechanism-Outcome) configuration framework.

Results

Three IDIs were conducted with administrators and leadership while two FGD were conducted independently with mentors and mentees. Themes for context, mechanism, and outcome were identified. The theme “Navigating Mentorship Challenges in the Professional Landscape” described the Context with subthemes: “Existence of mentorship culture”, Origins and Evolution of Mentoring” “Mentor’s pool, Availability of resources and Mentorship to Seniors. ‘Synergies in Professional Development: From Interdepartmental Collaboration to Mentor-Mentee Connections’ was the theme for mechanisms with subthemes; ‘Fostering Interdepartmental Collaboration’ ‘Building Connections’, ‘sharing of thoughts’, Work Driven Model, Mentor mentee pairing and Selection of mentor. Theme: ‘Cultivating Excellence in the Orchard for Outcome’ emerged from ‘Exchange of Insights in the Orchard of Mentorship’ and ‘Skills Development” constituted the Outcome theme.

Conclusions

The mentorship program at AKU-SONAM facilitated mentors and mentees to establish connections and exchange ideas. While the mentor-mentee pairing process was clearly outlined, participants emphasized the need to address the challenges encountered by mentees. Although the outcomes were not explicitly clarified, the program contributed to the advancement of the professional development of mentees at AKU-SONAM.
Peaceful dying among Canada’s elderly: An analysis of the Canadian Longitudinal Study on Aging
Authors: Aryal Komal , Jones Aaron , Tanuseputro Peter , Griffith Lauren E. , Hebert Paul C. , Kirkland Susan , Cook Deborah J. , Costa Andrew P.
Published: January 2025

Introduction

Death is universal, yet relatively little is known about how Canadians experience their death. Using novel decedent interview data from the Canadian Longitudinal Study on Aging we describe the prevalence and characteristics of peace with dying among older Canadians.

Methods

We conducted a secondary analysis of decedent interview data from the Canadian Longitudinal Study on Aging. Proxies of deceased Canadian Longitudinal Study on Aging participants reported on participants’ end-of-life experiences between January 2012 to March 2022. We examined end-of-life characteristics and their association with proxy reports of experiencing peace with dying. We conducted regression analysis to explore the association between demographic and end-of-life characteristics and experiencing peace with dying.

Results

Of 3,672 deceased participants, 1,287 (35.0%) had a completed decedent questionnaire and were included in the analysis. Respondents reported that two-thirds (66.0%) of the deceased experienced peace with dying and 17% did not experience peace with dying. The unadjusted odds of experiencing peace with dying were higher for those with an appointed power of attorney (OR 1.80; CI 1.39–2.33), those who died of cancer (OR 1.71; CI 1.27–2.30), those in hospice/receiving palliative care (OR 1.67; CI 1.19–2.37), individuals older than 75 years (OR 1.55; CI 1.04–2.30), or widowed (OR 1.53; CI 1.12–2.10). Widowhood (OR 1.51; CI 1.01–2.29), having an end-of-life SDM (OR 1.58; CI 1.14–2.17), and dying of cancer (OR 1.67; CI 1.19–2.23) increased the adjusted odds of dying with peace.

Conclusions

Close to 1 in 5 older Canadians may not experience peace with dying, which supports greater focus on improving the end-of-life care. Our findings suggest that advanced planning may enhance the experience of a peaceful death in Canada.
Comparative readability of information on different treatment options for breast cancer, based on WeChat public accounts
Authors: Li Bingyan , Liu Jia , Zhang Yuxi , Yang Wenjuan , Liu Min , Xie Lunfang
Published: January 2025

Objective

To evaluate and compare the readability of information on different treatment options for breast cancer from WeChat public accounts, propose targeted improvement strategies based on the evaluation of the results of the various treatment options, and provide a reference for producers of WeChat public accounts from which to write highly readable information regarding breast cancer treatment options.

Methods

With “breast cancer” as keywords in April 2021, searches were implemented on Sogou WeChat website (https://weixin.sogou.com/) and WeChat mobile app. The selected WPAs were aimed to provided breast cancer health information, and the four latest articles of each WPA were included in the evaluation. Two independent observers assessed the readability of the articles through the Suitability Assessment of Materials (SAM) tool, and compared the readability of information on different treatment options, i.e., surgical treatment, medical treatment, complementary and alternative medicine (CAM), and comprehensive treatment.

Results

A total of 136 articles on different types of breast cancer treatments from 37 WeChat public accounts were included in the present study. The median SAM score was 50 (IQR, 41–60). In terms of treatment options, the readability of articles in the CAM category scored higher in the content 75 (IQR, 63–81), learning stimulation and motivation 75 (IQR, 50–83) and cultural appropriateness 75 (IQR, 75–75) categories than in the medical and surgical treatment categories (P < 0.05). Additionally, the readability of articles in the CAM category scored higher in the cultural appropriateness 75 (IQR, 75–75) category than those for comprehensive and medical treatment (P < 0.05).

Conclusions

The overall readability of information on breast cancer treatment options in WeChat public accounts was in the lower portion of the “adequate” level. The readability of articles on medical treatment options is poor, especially on clinical trial articles, which could be improved in terms of content, graphics, learning stimulation, and motivation to make them more suitable for public reading.
Mathematical assessment of the role of temperature on desert locust population dynamics
Authors: Mamo Dejen Ketema , Kinyanjui Mathew N. , Siewe Nourridine
Published: January 2025

This study presents a novel non-autonomous mathematical model to explore the intricate relationship between temperature and desert locust population dynamics, considering the influence of both solitarious and gregarious phases across all life stages. The model incorporates temperature-dependent parameters for key biological processes, including egg development, hopper growth, adult maturation, and reproduction. Theoretical analysis reveals the model’s capacity for complex dynamical behaviors, such as multiple stable states and backward bifurcations, suggesting the potential for sudden and unpredictable population shifts. Sensitivity analysis identifies temperature-related parameters as critical drivers of population fluctuations, highlighting the importance of accurate temperature predictions for effective management. Numerical simulations demonstrate the significant impact of temperature on population growth, with optimal conditions promoting rapid development and increased survival, while extreme temperatures can hinder population growth and trigger phase transitions. By providing a deeper understanding of temperature-driven population shifts, this model enhances the ability to predict locust outbreaks, optimize control strategies, and reduce the socio-economic and ecological impacts of locust invasions.
Association of chronic kidney disease with acute clinical outcomes and hospitalization costs of cancer resection
Authors: Sakowitz Sara , Bakhtiyar Syed Shahyan , Mallick Saad , Vadlakonda Amulya , Oxyzolou Ifigenia , Ali Konmal , Chervu Nikhil , Benharash Peyman
Published: January 2025

Purpose

Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have been noted to face increased cancer incidence. Yet, the impact of concomitant renal dysfunction on acute outcomes following elective surgery for cancer remains to be elucidated.

Methods

All adult hospitalizations entailing elective resection for lung, esophageal, gastric, pancreatic, hepatic, or colon cancer were identified in the 2016–2020 National Inpatient Sample. Based on stage of renal dysfunction, CKD patients were sub-classified as CKD1-3, CKD4-5, or ESRD (others: Non-CKD). Multivariable regression models were developed to assess the association of comorbid CKD/ESRD with in-hospital mortality, perioperative complications, and resource utilization.

Results

Of ~515,145 patients, 32,195 (6.2%) had CKD (5.1% CKD1-3, 0.7% CKD4-5, 0.5% ESRD). The incidence of CKD among patients undergoing cancer resection increased from 5.3% in 2016 to 7.3% in 2020 (P<0.001). Following risk adjustment, CKD1-3 and CKD4-5 remained linked with similar likelihood of mortality and hospitalization costs, but greater need for blood transfusion (CKD1-3 AOR 1.21, CI 1.09–1.35; CKD4-5 AOR 1.73 CI 1.38–2.18). CKD4-5 was also associated with greater odds of infection (AOR 1.88, CI 1.34–2.62) and respiratory sequelae (AOR 1.36, CI 1.05–1.77). Further, ESRD was linked with greater odds of in-hospital mortality (AOR 2.74, CI 1.69–4.45), infection (AOR 2.31, CI 1.62–3.30) and respiratory complications (AOR 1.72, CI 1.31–2.26), as well as greater resource utilization, relative to Non-CKD.

Conclusion

Comorbid renal dysfunction was linked with inferior clinical and financial outcomes following elective cancer resection. Future work is needed to develop optimal management strategies and recovery pathways for this complex cohort.