bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of Sildenafil in Patients with Severe COVID-19 and Pulmonary Arterial Hypertension
Authors: Oliynyk Oleksandr Valentynovych , Rorat Marta , Strepetova Olena Vadymivna , Dubrov Serhij Oleksandrovych , Guryanov Vitaliy Grygorovych , Oliynyk Yanina Volodymyrivna , Kulivets Oleksii Serhijovych , Ślifirczyk Anna , Barg Wojciech
Published: May 2023

Pulmonary arterial hypertension (PAH) is common in severe coronavirus disease 2019 (COVID-19) and worsens the prognosis. Sildenafil, a phosphodiesterase-5 inhibitor, is approved for PAH treatment but little is known about its efficacy in cases of severe COVID-19 with PAH. This study aimed to investigate the clinical efficacy of sildenafil in patients with severe COVID-19 and PAH. Intensive care unit (ICU) patients were randomly assigned to receive sildenafil or a placebo, with 75 participants in each group. Sildenafil was administered orally at 0.25 mg/kg t.i.d. for one week in a placebo-controlled, double-blind manner as an add-on therapy alongside the patient’s routine treatment. The primary endpoint was one-week mortality, and the secondary endpoints were the one-week intubation rate and duration of ICU stay. The mortality rate was 4% vs. 13.3% (p = 0.078), the intubation rate was 8% and 18.7% (p = 0.09), and the length of ICU stay was 15 vs. 19 days (p < 0.001) for the sildenafil and placebo groups, respectively. If adjusted for PAH, sildenafil treatment significantly reduced mortality and intubation risks: OR = 0.21 (95% CI: 0.05–0.89) and OR = 0.26 (95% CI: 0.08–0.86), respectively. Sildenafil demonstrated some clinical efficacy in patients with severe COVID-19 and PAH and should be considered as an add-on therapy in these patients.
On-Board Smartphone-Based Road Hazard Detection with Cloud-Based Fusion
Authors: Bhosale Mayuresh , Guo Longxiang , Comert Gurcan , Jia Yunyi
Published: May 2023

Road hazards are one of the significant sources of fatalities in road accidents. The accurate estimation of road hazards can ensure safety and enhance the driving experience. Existing methods of road condition monitoring are time-consuming, expensive, inefficient, require much human effort, and need to be regularly updated. There is a need for a flexible, cost-effective, and efficient process to detect road conditions, especially road hazards. This work presents a new method to deal with road hazards using smartphones. Since most of the population drives cars with smartphones on board, we aim to leverage this to detect road hazards more flexibly, cost-effectively, and efficiently. This paper proposes a cloud-based deep-learning road hazard detection model based on a long short-term memory (LSTM) network to detect different types of road hazards from the motion data. To address the issue of large data requests for deep learning, this paper proposes to leverage both simulation data and experimental data for the learning process. To address the issue of misdetections from an individual smartphone, we propose a cloud-based fusion approach to further improve detection accuracy. The proposed approaches are validated by experimental tests, and the results demonstrate the effectiveness of road hazard detection.
Review of Canine Lymphoma Treated with Chemotherapy—Outcomes and Prognostic Factors
Authors: Bennett Peter , Williamson Peter , Taylor Rosanne
Published: May 2023

While canine lymphoma is a relatively common and important disease seen by veterinarians, there are limited comprehensive reviews of the literature regarding the remission and survival times following chemotherapy, and the associated prognostic factors. This comprehensive thematic review covers the available veterinary literature covering treatment outcomes and identified prognostic factors. A lack of standardised approaches to evaluate and report the outcomes was identified, including factors that would alter the duration of responses by weeks, or occasionally months. After publication of the suggested reporting criteria, this has improved but is still not uniformly applied. The prognostic factors included for evaluation varied from as few as three to seventeen, with over 50 studies using only univariate analysis. Individual papers reported much longer outcomes than others, but assessing the outcomes overall, there has been minimal change over the last 40 years. This supports the belief that novel approaches for lymphoma therapy will be required to substantively improve outcomes.
Wave Buoy Measurements at Short Fetches in the Black Sea Nearshore: Mixed Sea and Energy Fluxes
Authors: Rybalko Aleksandra , Myslenkov Stanislav , Badulin Sergei
Published: May 2023

Wave buoy measurements were carried out near the northeastern Black Sea coast at the natural reserve Utrish in 2020–2021. In total, about 11 months of data records were collected during two stages of the experiment at 600 and 1500 m offshore and depths of 18 and 42 m. The measured waves propagate almost exclusively from the seaward directions. Generally, the waves do not follow the local wind directions, thus, implying a mixed sea state. Nevertheless, dimensionless wave heights and periods appears to be quite close to the previously established empirical laws for the wind-driven seas. The results of the wave turbulence theory are applied for estimates of spectral energy fluxes and their correspondence to the energy flux from the turbulent wind pulsations. These estimates are consistent with today’s understanding of wind–wave interaction. It is shown that the main fraction of the wind energy flux is sent to the direct Kolmogorov–Zakharov cascade to high wave frequencies and then dissipates in small amounts. Less than 1% of the wind energy flux is directed to the low frequency band (the so-called inverse Kolmogorov–Zakharov cascade), thus, providing wave energy growth.
Microbial Enhancement of Selenium Removal in Chemically Modified Zeolite Columns
Authors: Kulasekara Herath Mudiyanselage Ishani P. , Zhang Yanyan , Papelis Charalambos
Published: May 2023

Selenium (Se) is an essential micro-nutrient for living organisms, but elevated concentrations in water can adversely affect health. In this research, we investigate the removal of selenium oxyanions (selenate and selenite) in aqueous systems by integration of adsorption on modified zeolites and microbial reduction. Dynamic sorption-reduction experiments were conducted using two sets of zeolite columns for the removal of selenite and selenate oxyanions, respectively. In each case, one column was fully packed with natural, unmodified zeolites, while the other column was composed of 80% natural and 20% iron-coated zeolites, by mass. The initial selenium concentration, selenite (SeIV) or selenate (SeVI), was 790 μg/L, the pH was 7.5, and the flow rate was 3 mL/min. Initially, as expected, the higher selenate removal (34%) was observed with coated zeolite, twice as high compared to the results with unmodified zeolite. Maximum selenite removal was 89% in the column with modified zeolite. Within approximately 14 days, as the biofilm developed inside the columns, selenium reduction in all four columns reached approximately 99%. Biofilm microbial community composition, assessed by 16S rRNA sequencing, is consistent with the presence of mainly selenium-reducing bacteria (Veillonella, Bacteroides, and Escherichia). Selenium oxyanions were reduced to elemental selenium, visible within the bioreactors as red-color aggregates.
Effect of Nitrate Presence on Selenium Bioremediation in Chemically Modified Zeolite Columns
Authors: Kulasekara Herath Mudiyanselage Ishani P. , Zhang Yanyan , Papelis Charalambos
Published: May 2023

Selenium is an essential micro-nutrient for living organisms, but elevated concentrations of it in water can adversely affect health. Nitrate is often found in selenium-contaminated water and negatively correlates with selenium removal. In this study, we investigate the effect of nitrate co-existence on selenium bioremediation in chemically modified zeolite columns. Dynamic sorption-reduction experiments were conducted using natural and iron-coated zeolite columns to remove selenite and selenate oxyanions separately, with and without nitrate anions. Anaerobic sludge was included as microbial inoculum, while lactate was the sole electron donor. The initial selenium concentration (SeIV or SeVI) was 790 µg/L, the nitrate concentration was 620 mg/L, the pH was 7.5, and the flow rate was 3 mL/min. Before introducing nitrate ions, selenium reduction in all four columns reached approximately 99%. However, after introducing nitrate ions, selenate and selenite reduction efficiencies were reduced to approximately 93% and 60%, respectively. Biofilm microbial community composition, assessed by 16S rRNA sequencing, was distinct between the communities with and without nitrate anions. Specifically, in the absence of nitrate, biofilm communities are mainly composed of selenium-reducing bacteria (Veillonella, Bacteroides and Escherichia). In contrast, the presence of nitrate led to mostly denitrifying bacteria (Anaeromusa-Anaeroarcus, Lentimicrobium, Azospirillum and Endomicrobium). Further, comparison of diversity indices (Shannon index, Faith PD and Pielou’s) shows alteration in all indices in the presence of nitrate.
TANTANGAN SOSIAL EKONOMI PASCA COVID-19 MENGHADAPI ERA 5.0 SOCIETY UNTUK MENCAPAI KINERJA BERKELANJUTAN
Authors: Saputra Muhammad Haris , Fitriaty  , Firmasari Puja , Fadillah Yosi , R Mardiana , Hassandi Irfan
Published: May 2023

Pandemi Covid-19 telah membuat banyak perubahan pada masyarakat dimana segala sesuatu dituntut bersifat non fisik dan memanfaatkan semua jaringan atau koneksi internet. Mulai dari berbelanja menggunakan toko online hingga bekerja secara normal di kantor, kita bisa bekerja dari rumah. Kajian ini bertujuan untuk melihat gambaran revolusi masyarakat 5.0 dilihat dari berbagai perspektif. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan analisis literatur yang secara khusus membahas masyarakat pascapandemi dan menghadapi masyarakat 5.0. Hasil penelitian ini menunjukkan bahwa Era Society 5.0 merupakan era manusia dan teknologi. Teknologi sudah menjadi kebutuhan yang harus dipenuhi oleh semua orang. Teknologi yang saling berhubungan dan diakses tanpa batas menghadirkan situasi yang kompleks. perkembangan teknologi dan berdasarkan peluang yang melekat pada inovasi
Arte e cultura na modernidade-mundo : sociologia da cultura e da arte (ensaios)
Authors: Bueno Maria Lúcia , Guerra Paula
Published: May 2023

-
Piptoporus soloniensis (Dubois) Pilát, un polypore devenu rare en France ; mise au point taxinomique sur le genre Piptoporus P. Karst.
Authors: Rivoire Bernard , Gannaz Marcel , Pirlot Jean-Marie , Sellier Yann
Published: May 2023

La récente redécouverte en France par l’un d’entre nous (YS), d’un exemplaire de Piptoporus soloniensis (Dubois) Pilát, 1937, permet de présenter et illustrer cette rare espèce. Les deux autres Piptoporus connus du territoire métropolitain, P. betulinus (Bull.) P. Karsten et P. quercinus (Schrad.) P. Karsten, sont décrits et comparés avec cette espèce. Il est indiqué les évolutions taxinomiques de l’ancien genre Piptoporus, découlant de la phylogénie moléculaire. Une clé de détermination est proposée.
O programa nacional de alimentação escolar (PNAE) e sua relevância como política pública para o desenvolvimento da agricultura familiar: Estudo de caso no município de Umuarama-PR
Authors: Tessarotto André Luis , Belusso Diane , Gaiotto Paulo Alexandre
Published: May 2023

Este estudo objetivou analisar os efeitos da execução do Programa Nacional de Alimentação Escolar (PNAE) para a agricultura familiar no município de Umuarama-PR, avaliando sua estrutura e funcionamento como ferramenta para o desenvolvimento socioeconômico e ambiental dos participantes do programa. Para tanto, realizou-se levantamento de dados, entrevistas junto aos atores envolvidos na execução do programa e um estudo de caso com os agricultores familiares do município, a fim de avaliar a partir da lei nº11.947/09, a implementação da compra de alimentos para o PNAE municipal, traçando um diagnóstico sobre a participação da agricultura familiar no programa. Os resultados apontam que a Agricultura Familiar demonstrou ser eficaz para o PNAE, especialmente devido à articulação entre os agentes públicos com a cooperativa local de agricultores, assegurando o cumprimento ao direito à alimentação adequada dos estudantes e refletindo no desenvolvimento rural por meio do aumento da renda e garantia de comercialização de sua produção.
Implikatur dan Eksplikatur Percakapan Lokadrama “Lara Ati” Karya Bayu Skak (Kajian Pragmatik)
Authors: Sholihah Alvia Mustafidatus , Rumilah Siti
Published: May 2023

This article will discuss the context of the implications and explications of the language spoken in an early episode of a film/lokadrama by a YouTuber who is also a Bayu Skak actor. The data were analyzed with Grice's theory regarding explicators and implicatures. The research method used is descriptive qualitative. The film "Lara Ati" is a typical East Javanese drama with the accent "Urip lan karep ora sedalan" which gives the meaning that life and desires do not always match what is expected. The results of the study show that the speech between characters uses the dialect of everyday language so that it seems as it is and creates implicit meaning from the interlocutor speakers. The forms of implicature found are declarative (confirming) implicature; imperative implicature (giving an order); and interrogative implicature (asking). Based on the implicature function, there are those that show directive (ordering and begging) and expressive (low self-esteem and mocking).Keyword: implicature, explicature, pragmatics, and Lara Ati's film.Abstrak:Artikel ini akan membahas konteks implikasi dan eksplikasi tuturan berbahasa pada sebuah film/lokadrama episode awal garapan seorang youtuber sekaligus pemain film Bayu Skak. Data dianalisis dengan teori Grice terkait eksplikatur dan implikatur. Metode penelitian yang digunakan deskriptif kualitatif. Film “Lara Ati” merupakan lokadrama khas Jawa Timur dengan aksen “Urip lan karep ora sedalan” memberikan makna bahwa hidup dan keinginan tidak selalu sesuai dengan apa yang diharapkan. Hasil penelitian menunjukkan bahwa tuturan antartokoh menggunakan dialek bahasa sehari-hari sehingga terkesan apa adanya dan menimbulkan makna implisit dari penutur petutur. Bentuk implikatur yang ditemukan, yaitu implikatur deklaratif (mengkonfirmasi); implikatur imperatif (memberikan sebuah perintah); dan implikatur interogatif (bertanya). Berdasarkan fungsi implikaturnya, ada yang menunjukkan direktif (menyuruh dan memohon) dan ekspresif (rendah diri dan mengejek).Kata kunci: implikatur, eksplikatur, pragmatik, dan Film Lara Ati.
Pemerolehan Bahasa Anak Usia 4-5 Tahun di BIMBA AIUEO Merpati
Authors: Sarifah Riski Nur , Utami Zahwa Febby
Published: May 2023

Not a few parents trust BIMBA AIUEO as a good place to learn languages. This article will describe children's language acquisition that occurs in language tutoring places. The method used in this research is a qualitative descriptive method with data collection techniques using several methods such as observation for preliminary studies, interviews to collect data to be analyzed, also recording and observing. After getting the data then it is classified and tabulated. The results of the study can be concluded that (1) language acquisition occurs naturally, (2) language acquisition is influenced by biological factors, and (3) children's language acquisition is also influenced by the socio-cultural environment.Keywords: language; gain, childAbstrak Tidak sedikit orang tua yang mempercayai BIMBA AIUEO sebagai tempat untuk belajar bahasa dengan baik. Artike ini akan memaparkan  pemerolehan bahasa anak yang terjadi di tempat bimbingan bahasa. Metode yang digunakan dalam penelitian adalah metode deskriptif kualitatif dengan teknik pengumpulan data menggunakan beberapa cara seperti observasi untuk studi pendahuluan, wawancara untuk mengambil data yang akan  dianalisis, juga  melakukan rekaman dan pengamatan. Setelah mendapatkan data kemudian diklasifikasikan dan ditabulasi. Hasil penelitian dapat disimpulkan bahwa, (1) pemerolehan bahasa terjadi secara alamiah, (2) pemerolehan bahasa dipengaruhi oleh faktor biologis, dan (3) pemerolehan bahasa anak juga dipengaruhi lingkungan sosial-budaya.Kata kunci: bahasa; pemerolehan, anak
The influence of brand ambassadors and brand image on the intention to buy food products
Authors: Suleman Dede , Hasanah Yulia Nur , Sabil Sabil , Sofyanty Devy , Sjarief Rachmat , Saputra Fendi
Published: May 2023

The important role of digital era consumers in making the buying process is quite different from before. Therefore, it is necessary to do research on the effect of Brand Ambassadors and brand image on Purchase Intention to purchase frozen food. The population in this study is people who live in South Tangerang with a sampling technique in the form of purposive sampling of 120 respondents. This study uses AMOS SEM data analysis techniques. The results of this study say that brand ambassadors and brand image have an effect on consumer buying interest and brand image is the factor that has the greatest influence on consumer buying interest.
Analysis of the perception of free shipping promotions on purchasing decisions on the Shopee marketplace
Authors: Prayitno Sentot Basuki
Published: May 2023

The free shipping promotion is one of many factors that influence purchasing decisions on the Shopee marketplace. The purpose of this study is to ascertain people's perceptions of the impact of free shipping Shopee promotions on purchasing decisions. A qualitative research approach is used in this study. This study relied on primary data gathered through interviews. The Snowball Sampling method was used to find 11 informants majoring in management at Sampoerna University. The study was carried out between January and February of 2023. In the data analysis process, this study used data reduction, data display, and conclusion. The findings of this study indicate that Shopee's free shipping promotion affects purchasing decisions, with buyers believing that free shipping promotions allow them to save more money, making them more enthusiastic about buying or transacting with the application. Promotions and prices influence purchasing decisions, which are supported by indicators such as advertising, personal selling, sales promotion, publicity, affordability, price per product, and price per benefit, being able to compete with other companies to influence purchasing decisions based on indicators such as product choices, brands, and more
Detection of COVID-19 Disease with Machine Learning Algorithms from CT Images
Authors: EKERSULAR Mahmut Nedim , ALKAN Ahmet
Published: May 2023

COVID-19, caused by the SARS-COV-2 virus, which has killed more than 6 million people, is one of the most contagious diseases in human history. It has seriously affected every area that people come into contact with, from business life to economy, from transportation to education, from social life to psychology. Although the developed vaccines provide a partial decrease in the number of deaths, the mutations that the virus constantly undergoes and the increase in the transmission rate accordingly reduce the effectiveness of the vaccines, and the number of deaths tends to increase as the number of infected people. It is undoubtedly important that the detection of this epidemic disease, which is the biggest crisis that humanity has experienced in the last century after World War II, is carried out accurately and quickly. In this study, a machine learning-based artificial intelligence method has been proposed for the detection of COVID-19 from computed tomography images. The features of images with two classes are extracted using the Local Binary Pattern. The images reserved for training in the dataset were used for training machine learning models. Trained models were tested with previously unused test images. While the Fine K-Nearest Neighbors model reached the highest accuracy with a value of 0.984 for the training images, the highest accuracy value was obtained by the Cubic Support Vector Machine with 0.93 for the test images. These results are higher than the deep learning-based study using the same data set.
Analysis of the income elasticity of demand for recreational and environmental of three ecosystems in Mexico
Authors: Blas-Cortés Jonatan , Omaña-Silvestre José Miguel , Quintero-Ramírez Juan Manuel , Montiel-Batalla Blanca Margarita
Published: May 2023

The objective of this research is to estimate the income elasticity of demand for environmental services of three ecosystems in Mexico. In the three studies of stated preferences about the willingness to pay for an environmental quality improvement project, we used a sample size of 289 observations for the Primas Basalticos ecosystems and 150 for the La Michilía Biosphere Reserve and the Molino de Las Flores National Park. The selection of interviewees was random among visitors. To carry out the estimation, a cluster analysis was carried out to determine the income strata, where the indicator was formulated and calculated in each ecosystem for three income strata (high, medium and low) based on a segmentation of the consumers of recreational services through the two-stage clustering method. In this way, the recreational services of the three ecosystems in both cases behave as a normal good; that is, if the income of the high and middle income consumer increases, the demand for recreational services will increase less than proportionally.
The Development of Foreign Language Communicative Competence of Future Marketing Professionals by Means of Social Networks
Authors: Lykhoshved N.
Published: May 2023

The article analyzes the potential of social networks in teaching foreign languages to students specializing in marketing in view of developing foreign language communicative competence while mastering social media marketing skills. Two modes of learning are singled out based on students’ involvement and level of independence: active and passive. Within the passive mode students use the existing social networks, groups and public pages that are designed for the purpose of language learning. Within the active mode students create their own content and administer their own groups, public pages etc. in social networks, thus acquiring hands- on experience in using the language and promoting their content, which is a crucial element in social media marketing, and therefore the necessary competence for future marketing specialists. The article analyzes SMM skills to be mastered by students specializing in marketing, and the forms, methods and ways of using social network in language teaching to marketing professionals. The long-term project is suggested to be implemented in the course of teaching foreign languages through the means of social networks. The objective of the project is to create and promote a language learning group or a public page in a social network with over a thousand followers. The following project stages are developed: 1) Initial stage: creating the group, distributing duties, engaging the first wave of followers; 2) Developing content; 3) Promotion; 4) Commercial application. Tasks and learning objectives are developed for each stage. The project is designed to be adjusted to various motivation levels and learning loads.
ANALYSIS OF MANAGEMENT KNOWLEDGE IN HANDLING 2019 CORONA DISEASE PANDEMIC AT SUKARAME HEALTH CENTER, DISTRICT OF NORTH LABUHAN BATU IN 2022
Authors: Mayang Tengku Mestika , Simarmata Marice
Published: May 2023

Background: WHO stated that Europe has become the center of the Coronavirus pandemic. Because more cases and deaths from Covid-19 have occurred in Europe. The number of patients infected with Coronavirus disease has reached 2.24 million people in the world. The United States is the country with the largest number of Covid-19 contributors in the world, with around 700 thousand people. The Coronavirus disease 2019 pandemic has existed in 185 countries and killed 153,822 people. At present, the total number of sufferers of Coronavirus disease in the world is 382 million people, of which the United States 75.4 million, India 41.6 million, Brazil 25.6 million, France 19.1 million, the United Kingdom 17.4 million (WHO, 2022 ). Objective: To analyze management knowledge in handling the 2019 coronavirus pandemic at the Sukarame Public Health Center in Labuhan Batu Utara Regency in 2022. Methods: This study used a qualitative approach. This research is comprehensive, dynamic, and does not generalize. Results: This research was directed at how the Sukarame Health Center in Labuhan Batu Utara handled the spread of Covid 19. The impact of Covid 19 greatly disrupted the health, economic, social, and cultural sectors. Therefore, the role of the Puskesmas must have a good strategy for suppressing the spread of Covid-19 which is very important.
THE EFFECT OF MODERN DRESSING TREATMENT ON WOUND HEALING PROCESS OF DIABETES MELLITUS
Authors: Karokaro Tati Murni , Erika Ribka
Published: May 2023

Diabetes mellitus merupakan gangguan metabolik kronis progresif disertai dengan tanda dan gejala glukosa dan metabolisme lemak yang mengalami komplikasi kronis hingga mengakibatkan konstriksi pembuluh darah. Penelitian ini dilakukan untuk mengetahui pengaruh modern dressing terhadap skor penyembuhan luka diabetes melitus. Metode penelitian yaitu pre-eksperimen, pre-test dan post-test design. Penderita Diabetes Melitus yang diberikan perlakuan yaitu 25 responden dengan instrument evaluasi penelitian menggunakan lembar observasi. Subjek dalam penelitiian ini lebih banyak perempuan (60%) pad usia 30-65 tahun (60%), tingkat pendidikan menengah pertama (66%), pekerja swasta (24%), menderita diabetes 1-3 tahun (80%). Analisis statistic yang dilakukan yaitu paired sampel t-test didapatkan hasil penelitian dengan perbedaan signifikan p-value = 0,000 (<0,005) dengan rerata skor penyembuhan luka diabetes mellitus pre dan post diberikan intervensi teknik modern dressing. Penelitian ini menemukan penyembuhan luka diabetes mellitus dengan metode Modern dressing. Intervensi ini dapat direkomendasikan untuk penderita diabetes mellitus. Saran yang disampaikan kepada perawat adalah agar perawat mengaplikasikan dan menggunakan tehnik perawatan modern dressing agar proses penyembuhan mellitus lebih cepat.
Factores pronósticos de la supervivencia en pacientes con melanoma de piel metastásico, que reciben primera línea de tratamiento con inmunoterapia anti PD-1 o régimen con anti PD-1 y anti CTLA-4, en el Instituto Nacional de Cancerología de Colombia
Authors: Zuluaga Liberato Andrea Marcela , Bonilla González Carlos Eduardo , Contreras Mejía Fernando , Carreño Dueñas José Alexander
Published: May 2023

Introducción. En melanoma metastásico, uno de los estándares de tratamiento es la inmunoterapia anti-PD-1 y anti-CTLA-4. El objetivo de esta investigación fue determinar factores pronósticos asociados con la supervivencia de pacientes con melanoma metastásico, con primera línea con inmunoterapia anti-PD-1 o anti-PD-1 y anti-CTLA-4, en el Instituto Nacional de Cancerología de Colombia.
Métodos. Se revisaron 63 historias clínicas del Instituto Nacional de Cancerología de enero de 2016 a abril de 2020. Se realizó un análisis de supervivencia con método de Kaplan-Meier, prueba log-rank y regresión de Cox.
Resultados. La mayoría de los pacientes fueron mujeres (58,7%); 47,6% tenían subtipo lentiginoso acral, 17,4% BRAF mutado, 20,6% compromiso en SNC, 50,8% recibieron nivolumab, 41,3% pembrolizumab y 7,9% nivolumab + ipilimumab. La mediana de supervivencia libre de progresión fue de 7,3 meses, con una tasa a 1, 2 y 3 años de 38%, 22% y 12% respectivamente; la mediana de supervivencia global fue 12,2 meses con una tasa a 1, 2 y 3 años de 50%, 25% y 19%. Como factor pronóstico protector para SLP se encontró el recibir nivolumab en comparación con pembrolizumab (HR=0,427; IC95% 0,21-0,86) y para SG el estado funcional al diagnóstico (ECOG 2 HR=12,38; IC95% 2,20-69,45).
Conclusión. La SLP y SG fueron menores a la de ensayos clínicos aleatorizados en población caucásica, pero similar a la encontrada en estudios que incluyen mayor proporción del subtipo histológico lentiginoso acral, como la nuestra. Se encontraron como factores pronósticos el tipo de inmunoterapia utilizada y el estado funcional al diagnóstico.
MANUFACTURE OF A DEVICE FOR PRUNING FRUIT BRANCHES
Authors: AL-GEZAWE Adel , COTTB Mokhtar , ABD EL GAWAD Fatma , AWAD Mahmoud , FOUDA Osama , OKASHA Mahmoud
Published: May 2023

Fruit branch pruning is still done manually, resulting in high labor costs, ergonomic hazards, and low efficiency and productivity. Furthermore, there are some limitations with imported agricultural machines because of their high prices and inappropriate local conditions. Hence, the present study aims to manufacture a local device for fruit branch pruning based on validating the correct stem-cutting position using a branch guide. The manufactured device comprises a 60 W electric motor, a formed base, a teethed pruning disc, a telescopic tube made up of the picker-cutting mechanism of the device, and a 12–Volt rechargeable dry battery. The device was made from local and light materials to allow a telescopic tube to reach the high position of the citrus fruit branches and consider ergonomic aspects. Field trials were executed on sour oranges trees to assess the pruning device’s performance as a function of change in cutting disc speeds (9.81, 13.74, 17.66, and 21.59 m/s), cutting disc teeth numbers (60, 80, and 100 teeth), different groups of branches diameters {A (from 5 mm to less than 10 mm), B (10 mm to less than 20 mm), C (from 20 mm to less than 30 mm) and D (from 30 mm to less than 40 mm)}. The manufactured device was assessed in terms of device productivity, pruning efficiency, pruning damage, power requirements, specific energy, and operating cost. The results indicated that the highest device productivity and pruning efficiency were 780, 218, 100 and 65 branch/h; and 96.0, 94.0, 92.0 and 90.5%, while the lowest pruning branch damage were 4.0, 6.0, 8.0 and 9.5%, specific energy were 0.0447, 0.1645, 0.4050 and 0.700 Wh per branch, for the groups of branches diameters A, B, C, and D respectively. The current investigation recommended that the optimal operational conditions were using the manufactured device for pruning citrus trees at 17.66 m/s pruning disc speed with a pruning disc teeth number of 60 teeth.
Avaliação do conhecimento de estudantes de Odontologia sobre a transmissão e prevenção de infecções sexualmente transmissíveis
Authors: Arruda Jônathas de Lima , Ribeiro Maria Izabel , Leonel Augusto César Leal da Silva , Silva Fábio Barbosa da , Perez Danyel Elias Cruz , Carvalho Elaine Judite de Amorim
Published: May 2023

Objetivo: Conhecer o perfil demográfico e comportamento sexual e conhecimento clínico no que se refere à prevenção de IST dos estudantes do 4º ao 10º período do Curso de Odontologia de uma universidade brasileira.
Métodos: Tratou-se de um estudo transversal, realizado através da aplicação de um questionário com perguntas sobre aspectos sociais, demográficos, econômicos e relativos às formas de transmissão e expressão clínica de IST. Os dados foram analisados descritivamente (médias, medianas, desvio padrão), assim como também foi realizada a análise estatística inferencial, com nível de significância de 5%. O programa utilizado para executar as inferências foi o SPSS, versão 23.
Resultados: Constatou-se, preliminarmente, predominância de brancos entre os entrevistados, baixo uso de preservativos nas relações sexuais, altos índices de realização de teste para detecção de HIV e falhas no conhecimento em identificar IST passíveis de transmissão durante o atendimento odontológico.
Conclusão: Há falhas no aprendizado do público-alvo da pesquisa, refletindo em desconhecimento sobre a prevenção, transmissão, sinais e sintomas de IST que envolvam a boca e seus anexos.
HOPELESSNESS AMONG NURSING STUDENTS DURING THE EARLY PHASE OF COVID-19 PANDEMIC : ONLINE CROSS SECTIONAL STUDY AT UNIVERSITAS RESPATI YOGYAKARTA
Authors: Fitriawan Akbar Satria , Widayati Ririn Wahyu , Rizqi Januar , Alfrendo C.Riyan
Published: May 2023

Background: Global pandemic of COVID-19 caused unprecedented effect in education sector due to the university closure and distance education, which could significantly affected students mental health and increased suicidality. Nursing students are vulnerable population due to already stressful academic activities coupled with pandemic loneliness and financial difficulties. Hopelessness, a negative view of the self in relation to the world and the future, identified as consistent predictor of suicidality. This study aimed to explore the prevalence of hopelessness among nursing students and association between sociodemographic characteristic and hopelessness.

Methods: Online cross sectional study was conducted in Universitas Respati Yogyakarta between June until September 2020, and involved 232 nursing students that selected using consecutive sampling method. Sociodemographic questionnare and Beck Hopelessness Scale (BHS) were used to collect the data. Chi square test was used to analyze association between sociodemographic characteristic and hopelessness.

Result: Our study elucidated that the prevalence of hopelessness among nursing students at Universitas Respati Yogyakarta during the early phase of COVID-19 pandemic is 9.5%. Chi square test revealed that there is no significant association between any sociodemographic characteristic and hopelessness (p>0.05).

Conclusion: The prevalence of hopelessness among nursing students is low, and sociodemographic profiles is not determinant of hopelessness.
REDUCING THE NUMBER OF SMOKING THROUGH HEALTH EDUCATION AND SEFT THERAPY IN THE PADUKUHAN KARANGSARI
Authors: Asmarani Fajarina Lathu , Syafitri Endang Nurul , Luturmas Ametkabal K.
Published: May 2023

There is a tendency to start smoking at a younger age. The number of teenage smokers in the world is 30%. In Indonesia, smokers aged 10-18 are 9.1%. In Yogyakarta, 1129 male students were smokers. Karangsari Padukuhan shows 27.5% of teenagers smoking. There is a lot of evidence that shows the bad effects of smoking so that it requires intervention. Interventions that can be given are to provide health education about the dangers of smoking and SEFT therapy. This research method is quasy experimental quantitative research. This research was conducted in Karangsari Elementary School. The data collection time is October, 2022. The sample in this study was selected from an affordable population using the purposive sampling method. The number of samples studied in this study was 30 adolescents. The measuring instrument uses the questionnaire. Data analysis using Wilcoxon. The average number of cigarettes per day is 4.3. After giving the intervention showed 3.43. The value of α shows 0.000, which means that there is an effect of providing health education about the dangers of smoking and SEFT therapy with the number of cigarettes daily. The conclusion of this study is that health education and SEFT therapy are scientifically proven to reduce the number of cigarettes
Sino words and non-Sino words in Chinese: focused on the confusion in the Chinese vocabulary category with the advent of alphabetic words
Authors:   The Society For Chinese Humanities In Korea, Kim Sok Yong
Published: May 2023

This study analyzes that the Chinese lexical category has been divided into Sino words and non-Sino words due to the rapid increase of alphabetic words in the 1990s, and the internal composition of the two categories is by no means uniform, so the relationship with existing lexical categories is bound to be confusing. First of all, the existing studies set up the concept of alphabetic words as a concept that refers to all word forms that are written with the alphabet, but this study confirmed that there are words that are written in the alphabet but cannot be considered as pure alphabetic words, and defined alphabetic words as words that exist only in alphabetic form, in terms of the essence of the word form. In this way, even if we strictly define alphabetic words based on the nature of the word form, there are both loan words and native Chinese word forms within Sino words and alphabetic words, respectively, and if we further subdivide native words and loan words into native Sino words, Chinese alphabetic words, loan-translations(calques), Sino-xenic words, hybrid words, and phonetic loans, each lexical category does not form a consistent spectrum with the two categories of Sino words and alphabetic words. This is different from the distribution of native words, Sino words, and loan words on a single horizon in Korean, Japanese, and Vietnamese, and can be attributed to the characteristics of the Chinese lexical system, which has long been characterized by the use of only Sino forms(Hanzici), and the Chinese environment, which is characterized by self-creating alphabetic words.
A Study on the Preface of the Water Margin of the Ming and Qing Dynasties from the “Four Elements of Literature” Perspective
Authors:   The Society For Chinese Humanities In Korea, Wang Lu Cheng
Published: May 2023

M.H. Abrams, a renowned American literary theorist of the time, put forward a famous theory of “four elements of literature”, pointing out that literary activities consist of four elements: “artist, world, and reader”. Based on this theory, this paper finds out the four elements in the prologue of The Story of the Water Margin of the Ming and Qing Dynasties.
This paper takes DingXigen's(丁锡根)Preface and Postscripts of Chinese Fictions(中国历代小说序跋集) as an example, and lists 22 preface and post scripts of Water Marginin(水浒传) Ming and Qing Dynasties. Contrasting with the “four elements theory of literature”, this paper briefly lists the four aspects of “work, world, author and reader” in the original preface.
At the level of works, it mainly analyzes whether the Water Margin is a “book of loyalty” or a “book of non-faithfulness”；At the level of world, the causes of Songjiang Uprising are analyzed: the social environment is dark, the officials force the people to revolt；At the level of author, the author's motivation and creation process of The Water Margin are analyzed；At the reader level of reader, this paper analyzes the reader types, how to read Water Margin well and the influence of reading Water Margin.
Analisis Kinerja Pengelolaan Limbah Infeksius Selama Masa Pandemi Covid-19 Studi Kasus di RSUD Kota Depok
Authors: Ulfimora Fara Asifa , Abidin Zaenal , Ismayana Andes
Published: May 2023

Medical waste management is one of the important things in handling the Covid-19 pandemic. Depok City is one of the areas of West Java Province in Indonesia which in the spread of Covid 19 is in the 5 (five) highest positions. The purpose of this research is the management of infectious waste before and during the emergence of the Covid-19 pandemic. This study used a qualitative method. Stages of research is the identification of performance and assessment of the performance of the management of infectious waste using the Balanced Scorecard method, identification plan management strategies using the SWOT method and prioritizing the implementation of the strategy with the method Interpretative Structural Modeling (ISM). The results showed that the infectious waste generation at the Depok City Hospital during the Covid-19 pandemic increased to 2.75 tons per year. The hospital has made efforts to reduce and sort out, but the obstacles faced during the sorting process are the limited number of Personal Protective Equipment (PPE) so that it can increase the risk of transmitting Covid-19 to officers and the absence of cold storage in the Temporary Disposal of Hazardous and Toxic Materials. (TPS B3). The Depok City Regional General Hospital (RSUD) has collaborated with third parties who have permits from the government. The most influential strategy that can be carried out by hospitals is to improve waste management facilities and infrastructure and strengthen SOPs with waste management parties.
Efektivitas Ukuran Blok Campuran Tanah dan Hydraulic Loading Rate Pada Multi Soil Layering Guna Menurunkan Parameter Fosfat dan Surfaktan Anionik di Usaha Binatu
Authors: Ramadani Tarikh Azis , Mayangsari Novi Eka , Anjani Mitha Amelia
Published: May 2023

The laundry business is one of the business that produces phosphate and anionic surfactant parameters that cause eutrophication and environmental pollution. Parameters of phosphate and anionic surfactants can be reduced using multi soil layering with two stages. This study aims to analyze the effect of soil mixed block size and hydraulic loading rate on reducing pollutant concentration. The materials used in this study are andosol soil, rice husk charcoal and iron powder. The permeable layer uses gravel and pearlite media. The reactor is made of acrylic with a length of 50 cm, a width of 15 cm and a height of 50 cm. Multi soil layering systems successfully reduce concentrations to 98,603% for phosphate parameters and 99.99% for anionic surfactant parameters. The decrease in phosphate parameters and anionic surfactants is caused by physical and chemical adsorption processes by soil components and rice husk charcoal. The decrease in the parameters of anionic surfactants is also helped by the process of biodegradation of microbes in the soil.
Pemberdayaan Kelompok Wanita Tani “Sri Rejeki” Melalui Budidaya Tanaman Sayuran di Bantul, DIY
Authors: Ismiasih Ismiasih , Trimerani Resna , Wahyu Ary Dewi Christina , Afroda Helmi
Published: May 2023

Women have an important role in a family. In supporting their role, many women are active in community organizations, one of which is the Women Farmers Group (KWT). However, KWT is often used only for meeting women without any productive activities. Therefore, through this community service program (PKM), it is hoped that it can raise independence for mothers to have productive. The partner in this PKM activity is KWT "Sri Rejeki" which is located in Bantul Regency. The PKM location was chosen with the consideration that KWT had quite a large yard of land and was not managed properly. Based on the situation analysis, it is known that the partners' problems include: yards that have not been managed properly, the activities of the women who have not been productive, the desire of the partners to provide knowledge and skills to members regarding the cultivation of horticultural. The solution to this problem is to carry out participatory extension and empowerment actions by combining direct practices of cultivation horticultural with modern methods. The type of program carried out is to train KWT members on modern cultivation of horticultural crops. After the activity was completed, an evaluation was carried out that the partner's knowledge, skills in plant cultivation and ability to use the land increased. As for the continuation of this PKM activity, it is hoped that the yard will become a productive garden, and partners will have a creative and productive spirit in utilizing their free time.
Eschatological Features in Malachi 4:1-6
Authors: Tembo Henry
Published: May 2023

This article exegetes the eschatology of Malachi 4:1-6. Most studies mention the subject in passing leaving the eschatology of the text opaque. The issue compounds when studies apply incomprehensive methodologies. The impact of this exegetical hole shows up in divergent views of fulfilment. A major area of interest among studies of prophetic texts. The article utilizes a multifaceted prophetic exegesis. The method incorporates various aspects of text analysis to define the eschatology within the text. It touches historical and literary aspects. It analyses issues related to typology. It’s focus leads the exegete to give due attention to fulfilment of prophetic texts. It uncovers the eschatological substructure imbedded in the text. The approach demonstrates that Malachi 4:1-6 contains eschatological features in the immediate context. These features transcend the immediate context when the person of John the Baptist and Jesus enter the biblical narrative. Beyond these two biblical figures. The study considers eschatology in light of the NT. At the end, the article summarizes and key findings
A Deep-Learning Based Real-Time Prediction of Seated Postural Limits and its Application in Trunk Rehabilitation
Authors: Ai Xupeng , Santamaria Victor , Chen Jiawei , Hu Boce , Zhu Chenfei , Agrawal Sunil
Published: May 2023

Seated postural limit defines the region from beyond which a subject cannot return the trunk to the neutral position without additional external support. The seated postural limits can be used as a reference to provide assistive support to the torso by an appropriately designed robotics, e.g., Trunk Support Trainer (TruST). However, fixed boundary representations of seated postural limits in the literature cannot capture the dynamically changing seated postural limits during training. In this study, we propose a conceptual model of the dynamic boundary of the trunk center using a boundary vector designed to track the postural-goal direction and trunk movement amplitude during a sitting task. We experimented with 20 healthy subjects. The results support our hypothesis that TruST intervention with an assist-as-needed controller based on the proposed dynamic boundary representation could achieve more significant sitting workspace area improvements than a fixed boundary representation. The second contribution of this paper is that we provide an approach to effectively introduce deep learning into TruST's real-time controller design. We compiled a 3D trunk movement dataset which is currently the largest in the literature. We designed a loss capable of solving the gate-controlled regression problem. We proposed a novel roadmap for the exploration study. Following the roadmap, we developed a deep learning architecture, modified the widely used Inception module, and then obtained a deep learning model capable of accurately predicting the dynamic boundary in real-time. We believe this approach can be extended across other rehabilitation robots towards designing intelligent dynamic boundary-based assist-as-needed controllers.
YoloCurvSeg: You Only Label One Noisy Skeleton for Vessel-style Curvilinear Structure Segmentation
Authors: Lin Li , Peng Linkai , He Huaqing , Cheng Pujin , Wu Jiewei , Wong Kenneth Kin-Yip , Tang Xiaoying
Published: May 2023

Weakly-supervised learning (WSL) has been proposed to alleviate the conflict between data annotation cost and model performance through employing sparsely-grained (i.e., point-, box-,  scribble-wise) supervision and has shown promising performance, particularly in the image segmentation field. However, it is still a very challenging task due to the limited supervision, especially when only a small number of labeled samples are available. Additionally, almost all existing WSL segmentation methods are designed for star-convex structures which are very different from curvilinear structures such as vessels and nerves. In this paper, we propose a novel sparsely annotated segmentation framework for curvilinear structures, named YoloCurvSeg. A very essential component of YoloCurvSeg is image synthesis. Specifically, a background generator delivers image backgrounds that closely match the real distributions through inpainting dilated skeletons. The extracted backgrounds are then combined with randomly emulated curves generated by a Space Colonization Algorithm-based foreground generator and through a multilayer patch-wise contrastive learning synthesizer. In this way, a synthetic dataset with both images and curve segmentation labels is obtained, at the cost of only one or a few noisy skeleton annotations. Finally, a segmenter is trained with the generated dataset and possibly an unlabeled dataset. The proposed YoloCurvSeg is evaluated on four publicly available datasets (OCTA500, CORN, DRIVE and CHASEDB1) and the results show that YoloCurvSeg outperforms state-of-the-art WSL segmentation methods by large margins. With only one noisy skeleton annotation (respectively 0.14%, 0.03%, 1.40%, and 0.65% of the full annotation), YoloCurvSeg achieves more than 97% of the fully-supervised performance on each dataset. Code and datasets will be released at https://github.com/llmir/YoloCurvSeg.