bluuebunny/crossref_metadata_2025 huggingface dataset:
Congenital cutis laxa with multi-system involvement
Authors: Malhotra Karan , Siddalingappa Karjigi , Herakal Kallappa C.
Published: February 2020

Cutis laxa is a heterogeneous group of inherited and acquired rare connective tissue disease characterized by loose, wrinkled, and inelastic skin. It clinically presents as loose skin with folds giving a premature aged appearance. Cutis laxa is very rare, with an estimated incidence of one in 4 million. There are many case reports on acquired cutis laxa but very few on “congenital” cutis laxa. Authors report a 15 years old female presenting with a history of recurrent respiratory tract infections since the age of 2 years associated with flaccid skin all over her body and extensive loose folds of skin over face, neck, abdomen, arms and thighs since birth. Cutis laxa has been diagnosed based on the clinical picture and histopathological appearance. No medical treatment is available for correction of the pathology of disease. Plastic surgery remains the only modality of treatment to improve the cosmetic appearance. Systemic abnormalities need specific treatment depending upon the condition. The purpose of this report is due to its rarity and involvement of skin, hairs, respiratory, cardiovascular and genitourinary system in a single patient.
Phthiriasis palpebrarum: a diagnosis of keen observation and suspicion
Authors: Sivasubramanian Muthu Bharathi , Ramakrishnan Ramachandran , Narasimhan Murali
Published: February 2020

Phthiriasis palpebrarum is a rare cause of eyelid infestation and it mimics seborrheic blepharitis. A 60 years old female presented with itching in the eyelids and scalp. On initial examination scaling was present in her eyelashes and eyelid margin. On further examination some movements were noticed in her eyelashes. Immediately, dermatoscopic examination was done and was found to have multiple nits and multiple crab lice over her eyelashes. She was treated with oral ivermectin and trimming of eyelashes as advised by ophthalmologist. She improved in a week. Thus, phthiriasis palpebrarum can mimick seborrheic blepharitis and therefore high index of suspicion and detailed examination is necessary for appropriate diagnosis.
The legal aspects faced by cosmetologists and dermatologists
Authors: Mohan Shobhit , Mohan Lalit , Sangal Renu , Singh Neelu
Published: February 2020

The present-day cosmetologists, in addition to conventional skin physicians, are also cosmetologists and minor skin surgeons in their practice. The cosmetic procedures have the risk of legal problems leaving an unsatisfied patient and troublesome law. One should have safe practice of cosmetology and possible complications and how to overcome these complications after cosmetology procedure. Doctor should know the routine precautions which help him to avoid unnecessary calls by the court.
STUDY OF HISTOLOGICAL FEATURES OF LIVER REACTION USING NEW SAMPLES OF POLYMERIC HEMOSTATIC MATERIALS IN THE EXPERIMENT IN VIVO
Authors: Lipatov Vyacheslav Aleksandrovich , Lazarenko Sergej Viktorovich , Severinov Dmitry Andreevich , Tarasova Anastasia Valeryevna
Published: February 2020

Abdominal trauma in 26.7-40.8% of cases is accompanied by trauma of parenchymal organs. The condition of the patient with liver injury in 75% of cases is complicated by the development of hemorrhagic shock. In surgery, to achieve local hemostasis, the most promising method is the topical use of application hemostatic agents, while the composition of such funds determines the effectiveness of hemostasis.
The aim of the study is to assess the histological characteristics of the liver using new samples of polymeric hemostatic materials in the experiment in vivo.
Materials and methods. As research material was used hemostatic sponge based on natrocarbonatite (Na-CMC) (developed jointly with Linteks, Russia. Saint-Petersburg.) In the experimental groups of laboratory animals under general anesthesia produced a median laparotomy and simulated planar surface injury to the liver. Parenchymal bleeding was stopped by applying application hemostatic materials. An autopsy of the injured area of the liver was performed together with an implanted hemostatic agent. The thickness of the capsule, the size of the Central veins of the liver, the number of dual-core hepatocytes, the size of hepatocytes and their nuclei were measured.
Results. The indicator of the area of hepatocytes of groups No. 4 and No. 5 are as close as possible to group No. 1 indicators. Similar to the area of hepatocytes, difference of the area of their kernels in groups No. 6, No. 7 are statistically not significant in comparison with group No. 1. In groups No. 6 and No. 5 the area of kernels is authentically increased, but does not reach values of control group. The greatest statistically significant increase in thickness of the capsule in comparison with group No. 1, group No. 2 and No. 3 was observed in group No. 4. The area of the central vein is authentically increased in comparison with control group in groups No. 2, No. 3 and No. 6. The number of two-nuclear hepatocytes in comparison with norm, group No. 4 and group No. 1 is reliable above in groups No. 6 and No. 7.
Conclusion. Histologic reorganizations, changes of morphological structure in places of a trauma and implantation of the tested samples are less expressed when using haemo static implants of experimental groups No. 3-№6 (styptic local means on the basis of Na-KMTs with addition of aminocaproic, acetilsalicylic and aminoacetic acids).
Rare case of massive localized hip lymphedema-pseudosarcoma
Authors: Dzhuganova Victoria Olegovna , Novomlinsky Valery Vasilyevich , Sokolov Andrei Petrovich , Lynov Pavel Alekseevich , Chvikalov Evgeny Sergeevich , Sokolova Margarita Gennedievna , Ostroushko Anton Petrovich , Laptiyova Anastasia Yurievna , Kutsuradis Azariy Falesovich
Published: February 2020

Массивная локализованная лимфедема (млл) или так называемая псевдосаркома - это явление вторичной лимфедемы, развивающейся вследствие ожирения, обусловленного нарушением лимфодренажа. MLL-это крупное доброкачественное опухолевое образование, связанное с переходом богатой белками жидкости в интерстициальное пространство с последующей активацией пролиферации интерстициальных клеток. Прогрессирующий рост ИИ в конечном итоге может привести к чрезвычайно большой массе, что затрудняет повседневную деятельность за счет ограничения подвижности, а также повышает риск повторного возникновения инфекций.Псевдосаркома-достаточно редкое заболевание, встречающееся среди населения, но по мере роста распространенности ожирения растет и заболеваемость больных.Важно учитывать, что клинические, гистологические и рентгенологические картины млл выглядят как злокачественные новообразования. Знание различий между этим состоянием и другими опухолями, помогает врачу быстро дифференцировать псевдосаркому и поставить правильный диагноз.Введем клиническое наблюдение за млл обработкой всей медиальной поверхности правого бедра с переходом на переднюю и заднюю поверхности
The Efficacy of Probiotics for Treatment of Bipolar Disorder- Type 1: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Eslami Shahrbabaki Mahin , Sabouri Saleheh , Sabahi Abdolreza , Barfeh Delaram , Divsalar Parisa , Divsalar Parisa , Esmailzadeh Mahdi , Ahmadi Atefeh
Published: February 2020

Objective: Bipolar disorders are among the most common chronic mental disorders. Despite the recent improvement in controlling psychiatric disorders, treatment of bipolar disorders remains a challenge.
The aim of this study was to determine the effect of consuming probiotics in patients with bipolar disorder-type 1 compared to the placebo group.
Method: This was a permuted blocked randomized clinical trial conducted in Shahid Beheshti mental hospital in Kerman, Iran, from October 2017 to October 2018. Two psychiatrists diagnosed and hospitalized all 38 patients with type 1 bipolar disorder based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Using blind randomized blocking method size 4, patients were divided into 2 groups of placebo and probiotic. Young Mania Rating Scale (YMRS) and Hamilton's Depression Rating Scale (HDRS) were completed at the beginning, week 4, and week 8 of the study by a psychiatry resident. Independent t test, Mann-Whitney and repeated measures ANOVA tests were used. Data were analyzed using SPSS software version 20.
Results: There was no significant difference between the 2 groups in age, sex, and severity of mania and depression. Consumption of probiotics reduced the scores of YMRS and HDRS over time in the probiotic group more than the placebo group, but it was not significant.
Conclusion: Consumption of probiotics had non-significant effects on improvement and treatment of bipolar type 1 patients. It is suggested that future studies be conducted with different probiotic microbial strains and longer period of treatment.
Applying Collaborative Care Model on Intensive Caregiver Burden and Resilient Family Caregivers of Patients with Mental Disorders: A Randomized Controlled Trial
Authors: Zoladl Mohammad , Afroughi Solaiman , Nooryan Khairollah , Kharamin Shirali , Haghgoo Amin , Parandvar Yaghoub
Published: February 2020

Objective: Psychological education for families in the form of a model is one of the effective approaches in managing problems caused by mental health problems. The present study aimed to determine the effect of using the participatory care model on the caregiver burden and resilience of home caregivers of patients with mental disorders.
Method: In this clinical trial, 66 households with psychiatric patients hospitalized at Shahid Rajaee Psychiatric Hospital in Yasuj during 2014-2015 were selected and assigned into 2 groups of experimental and intervention based on convenience and simple random sampling. The data of this study were gathered by Novak & Guest (1989) Caregiver burden and Sixbey (2005) Resilience Questionnaire before and after intervention. Participatory care model was performed for 12 ninety-minute sessions in the intervention group. No intervention was provided to the control group during the study period. SPSS software (version 21) was used to run the descriptive and inferential statistics.
Results: Chi-squared test showed that the caregiver burden was significantly lower in the experimental group than in the control group after the intervention (P = 0.0001). Following the intervention, increased resilience and all its components were observed in the experimental group compared to the control group. According to the independent t test and Mann-Whitney U, the 2 groups were considerably different (P < 0.05).
Conclusion: The application of the participatory care model efficiently increased resilience and decreased the intensity of the caregiver burden on the home caregivers of patients suffering from mental disorders.
Stress and Anxiety Levels Are Associated with Erythrocyte Fatty Acids Content in Young Women
Authors: Hashemi Samira , Amani Reza , Cheraghian Bahman , Neamatpour Sorour
Published: February 2020

Objective: Recent studies have revealed that fatty acid profile can be associated with psychological disorders. However, evidence on stress and anxiety is scarce. The aim of this study was to investigate the relationship between stress and anxiety, defined as mood states, and erythrocyte fatty acid (FA) profile.
Method: This case-control study was conducted on 45 female students with degrees of stress and anxiety without depression disorder and 45 matched controls with no depression, stress, or anxiety. Self-administered questionnaires included a 28-item Food Frequency questionnaire and Depression Anxiety Stress Scales (DASS-21), which were used to measure dietary patterns and psychological disorders, respectively. Erythrocyte membrane fatty acids were analyzed using gas-liquid chromatography.
Results: Docosahexaenoic acid (DHA) was significantly lower in the case group (p = 0.008). Hydrogenated fats were associated with degrees of stress and anxiety (OR = 1.53, p = 0.019), while linoleate and DHA were inversely associated with stress and anxiety scores (OR = 0.37, p = 0.05; OR = 0.31, p = 0.014, respectively). Monounsaturated FAs (MUFAs) and total RBC trans FA were associated with increased risk of stress and anxiety (OR = 1.81, p < 0.001; OR = 3.38, p = 0.003, respectively).
Conclusion: Trans-fatty acids may be related to stress and anxiety scales but linoleate and DHA could decrease the risk. The effect of MUFAs may be regarded as a result of compensatory biological mechanisms
Infertility and Psychological and Social Health of Iranian Infertile Women: A Systematic Review
Authors: Zarif Golbar Yazdi Haniye , Aghamohammadian Sharbaf Hamidreza , Kareshki Hossein , Amirian Malihe
Published: February 2020

Objective: Infertility influences various emotional, psychological, social, and relational aspects of women’s lives. By employing a systematic review on the papers published in this field, this study aimed to identify the consequences of infertility on psychological and social health of women in Iran.
Method: This was a descriptive study, conducted through a systematic review according to the directions denoted by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) in 2018. To investigate the entirety of the published studies on the sociopsychological consequences of women’s infertility in Iran, various databases, including Comprehensive Human Science Portal, Scientific Information Databases (SID), Magiran, National Library and Archives of I. R. IRAN, Noormags, MEDLIB, Science Direct, Google Scholar, Medline, and ProQuest, were explored for the studies published between 1991 and 2018. The selected papers were evaluated according to the content analysis method.
Results: Out of the 53 papers investigated, 27 were published in domestic journals (51%), while the remaining 26 papers were published in international journals and were in English (49%). The results revealed that sociopsychological consequences of women’s infertility are categorized in 6 main categories: (1) quality of life, (2) depression, (3) anxiety, (4) social support, (5) violence, and (6) sexual function.
Conclusion: The results of this study can be used to design psychocognitive interventions and assist women in decreasing the emerging psychological pain and pressure.
Massive Religiosity in Indonesian Poetry vs. Scarce Divinity in American Poetry
Authors: Kadarisman A. Effendi , Pratiwi Yuni
Published: February 2020

As revealed by earlier research (Kadarisman 2008 and 2016), Indonesian poetry strikingly differs from American poetry in terms of massive divine presence in the former vs. divine absence in the latter. The present research moves on further to find out (1) how Indonesian poets express their religiosity, and (2) whether or not, with newly collected data, God is truly absent in today’s American poetry. Upon closer examination of Indonesian and American poetry, the research has come up with the following findings. First, most Indonesian poets express their religious experience with reverence and solemnity, although a few of them do so with complaint and humor. Secondly, it is true that there is no divinity in American poetry in today’s academia; but religious poems keep surviving in church communities. Briefly, religiosity is always there in poetry; but it differs across both countries in terms of degree, as determined by different socio-political systems and cultural beliefs.
Keywords: massive religiosity, scarce divinity, Indonesian poetry, American poetry
Digitalization of Indonesian Culture: The 3-Dimentional Model of the “Patih” Character in Topeng Malang
Authors: Pramono Andy , Rahayuningtyas Wida , Hj. Ismail Adzrool Idzwan , Dewi Puspasari Betty , Bayu Pratama Rakha , Pangestu Laksono Akbar
Published: February 2020

The culture of Malang City cannot be separated from the traditional arts that exist therein.OfthefamousonesisTopengMalang, although it is now not as attractive as the modern art.TopengMalangispeculiarinthatithas67formsofmaskdesign.One way to preserve the Topeng Malang culture, especially regarding mask design, is through digitizing. This research focuses on digitizing the whole form of the Topeng Malang, especially the Patih character, in addition to developing these characters into human formwith3-dimensional modeling techniques.This is a descriptive procedural research model, resulting in a product. Data were obtained thtough observation, interviews and documentation. Observation collected visual data with regard to Topeng Malang’s forms, references for re-forming the Patih character, literature and survey result. The character re-formation applied to patterns, shapes and colors of the Topeng Malang. EnhancingthedesignofthePatihcharacterinTopengMalangassetswillrevitalizethe local wisdom in Malang and improve the recognition, pride, and image of Indonesian culture in the world. This result of this research can also be utilized as part of the materials for character education.
Keywords: Topeng Malang, 3D model, Patih character
Learning to Write Poetry Based on Social Environment for High School Students
Authors: Budi Qur’ani Hidayah , Anggraini Purwati , Widodo Joko
Published: February 2020

Writing Poetry is one of the basic competencies that must be mastered by students in high school. Writing poetry is also an effort to encourage literacy movements, especially literacy program in schools. To increase students’ interest in writing poetry, innovation is needed in the learning process. One of them is by using an interesting learning method by utilizing the social environment. This writing is an idea that discusses the learning method of case study based on the social environment as an alternative for students in writing poetry. The discussion in this paper includes (1) steps to implement a case study method based on social environment in learning to write poetry and (2) steps to write poetry based on the social environment by applying case study method.
Keywords: Learning to Write Poetry, Case Study, Social Environment
The Tradition of Pottery Craftsmanship and Its Transmission System in Pagelaran Village, Malang Regency
Authors: . Iriaji , Rohendi R Tjetjep , Sumaryanto F Totok , Sony K Dharsono
Published: February 2020

This research aims at analyzing the phenomenon of the culture and transmission system of pottery craftsmanship in Pagelaran Village, Malang Regency. The analysis was conducted thoroughly and comprehensively using qualitative approach and, specifically, with the help of phenomenologist research design. The field data were acquired from thorough interviews, FGDs, observations, and literary studies with the researcher as the key instrument. To prove the reliability of the data, the researcher used the techniques of source triangulation, method triangulation, and theory triangulation. The data were analyzed through the stages of data reduction, presentation, verification, and paradigmatic theory analysis by applying the perspective of socio cultural theory and arts education theory. The findings presented that: first, the cultural transmission of pottery craftsmanship in Pagelaran has been running through seven generations that is still being preserved and continued at the moment; second, there are three conceptualizations on the transmission system of pottery craftsmanship in Pagelaran, those are the transmission system in informal, non-formal, and formal educational institutions.
 
Keywords: pottery of Pagelaran, transmission system, arts education
Graduate Students’ Attitude Toward Plagiarism in Academic Writing
Authors: Rodhiya Najmi , Hermilia Wijayati Primardiana
Published: February 2020

Plagiarism is one of academic dishonesty that becomes a central issue and challenge faced by the educational sector. Students who study in a higher level of education will face many kinds of academic writing, which is not easy to deal with. Moreover, students need to find information related to their writing to support theories and arguments for their academic writing. This study aims to find out graduate language students’ attitude toward plagiarism in academic writing. This present study used a quantitative approach and survey as the design of the study. The target population was all of the graduate students in language study program in the second semester from four departments; English Language Teaching, Indonesian Language Teaching, Arabic Language Teaching, and Keguruan Bahasa department. 86 students were chosen as a sample using random sampling. Questionnaire and interview were used as the instruments in this study. The questionnaire was divided into three parts; cognitive, emotional and behavior. The result shows that 66% or 57 students have a neutral attitude toward plagiarism. It means that they knew that plagiarism was an improper action, but they can tolerate plagiarism action. However, 33% or 28 students have a negative attitude toward plagiarism which means that they cannot tolerate plagiarism action. In contrast, only 1% or 1 student has a positive attitude toward plagiarism which means that they do not think that plagiarism is an improper action.
Keywords: Attitude, Plagiarism, Academic Writing
Learning Strategy Patterns in Developing Skills for Listening of Arabic Speech
Authors: . Nurhidayati , . Irhamni , . Moh. Ainin
Published: February 2020

In accordance with the constructivist philosophy, student learning strategies are important things to be studied and activated by lecturers to achieve an effective level of learning in accordance with the characteristics of students who are ready to be independent. These strategies can be used for processing (internalitation), storage (starage), retrieval (retrival), and the use of newly learned languages. These strategies are also a set of tools for self-directed development of communication skills, including listening skills. Listening skills are an important part of communication, and are the basis of second language learning or foreign languages. The essence of interaction ability is the ability to understand what others say. The purpose of this study is to (1) describe the pattern of direct learning strategies used by students in listening to Arabic speech, describe the pattern of indirect learning strategies used by students in listening to Arabic speech, and (3) describe student perceptions of the importance learning strategies in developing listening skills. The design of this research is qualitative descriptive research. This research includes ethnometodology and phenomenology research that will reveal students’ learning attitudes both independent and guided learning in listening to Arabic speeches both in class and outside the classroom. The results showed that the direct learning strategies used by students in listening to Arabic speech can be categorized into three types, namely (a) memory strategy, (b) cognitive strategies, and (c) compensation strategies, the three strategies used by students when implementing skills listening in the class and outside the class with different compositions. The indirect strategies used by students when listening are: metacognitive strategies, affective strategies, and social strategies. These three strategies are used by students with techniques that vary with a number of different quantities. Based on the results of questionnaires, observations, and interviews, it was found that the majority of students used certain learning strategies in the listening process, both when listening guided in the laboratory and listening freely outside the laboratory.
Keywords: Learning Strategy Patterns, Developing Skills, Listening of Arabic Speech
Strategic Value of the Mental Revolution in the Prince Pekik Folktale
Authors: . Sudarwati , Andari Novi , . Pariyanto
Published: February 2020

The use of folktale as a medium of character education can certainly be explored in various ways – through the character’s behaviour, the character’s qualities, and the character’s way of speaking. Employing library and descriptive qualitative research method, the present study investigated the strategic values of mental revolution found in the main characters of Prince Pekik folktale. The finding suggests that throughout his reign the Prince Pekik possessed numerous exemplary qualities – i.e. wise, knowledgeable, motivated, smart, persistent, firm, humble, courageous, responsible, and conscionable. The implication of this study is that by studying the main character’s qualities of this folktale, character education can be taken place where mental revolusion is possibly promoted.
 
Keywords: Strategic values of mental revolution, folktale, educational media, Prince Pekik
The Effectiveness of Self Efficacy ˋˋBandura'' Learning Model in Digital-Based Topeng Malang Teaching
Authors: Rahayuningtyas Wida , Tri Wulandari Retno , Pramono Andy , . S.Kom , Prasetyo Mokhamad , Eka Maretta Shelby
Published: February 2020

As a teacher, it is important to decide the right learning model since it will determine learners’ motivation and achievements in the learning processes. Teachers should transfer knowledge and education in the most effective way to make sure that students understand the materials. Topeng Malang, as one of the sub material in the art and cultural subject, is designed in a way that students are interested in and has a high motivation to learn. The “Bandura” self-efficacy learning model in digital-based Topeng Malang learning produce an interactive digital book using Bandura theory. Mixed method was used in this study. The population of the study is VIII grade students in SMPN 4 Malang. The sampling method used was cluster random sampling which resulted in 30 students as the subjects. The data collection used a questionnaire of learners’ learning motivation and a test of learners’ achievements. The data analysis shows that “Bandura” self-efficacy learning model applied in the digital-based Topeng Malang learning gives 77,1% of contributions. It shows that the use of Bandura self-efficacy learning model in Topeng Malang learning is more effective compared to the conventional models.
 
Keywords: self-efficacy, wayang topeng learning, effectiveness
The impact of plasma glucose levels on in-hospital and long-term mortality in non-diabetic patients with ST-segment elevation myocardial infarction patients
Authors: TATLISU Mustafa Adem , KAYA Adnan , KESKİN Muhammed , KOZAN Ömer
Published: February 2020

Objective: Increased admission plasma glucose can be seen in the acute phase of acute coronary syndromes (ACS). Hence, we performed a retrospective study to evaluate the admission plasma glucose concentration in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) and who had no previous diagnosis of Diabetes Mellitus (DM).Method: This retrospective study included 2504 consecutive confirmed STEMI patients treated with pPCI. The patients were divided into quantiles according to the admission glucose levels. Quantile I: 94 ± 7 mg/dL (n= 626), quantile II: 112 ± 5 mg/dL (n = 626), quantile III: 131 ± 6 mg/dL (n= 626), quantile IV: 184 ± 46 mg/dL (n= 626).Results: Patients with higher plasma glucose (Q4) had 6.6 times higher in-hospital all-cause mortality rates (95% CI: 3.95–9.30) and 3.12 times higher (95% CI: 2.2–4.4) long-term all-cause mortality rates than patients with lower plasma glucose (Q1–Q3), who had lower rates and were used as the reference. This significant relationship remained even after adjustment for all confounders. Conclusion: Even though glucose-lowering therapy is recommended in ACS patients with glucose levels >180 mg/dL, our results showed that high plasma glucose, even lower than 180 mg/dL, could predict in-hospital and long-term mortality.
Korunmuş ejeksiyon fraksiyonlu kalp yetmezliği hastalarında sol atriyum mekaniğinin kardiyovasküler sonuçlar üzerine etkisi: Tek merkezli çalışma
Authors: KÜÇÜKSEYMEN Selçuk
Published: February 2020

Amaç Sol atrium mekaniği, temelde iletim zamanı, kalp yetmezliği
patofizyolojisinde özellikle de korunmuş ejeksiyon fraksiyonlu kalp
yetmezliğinde (KEFKY), diyastolik fonksiyonların bozulmasına bağlı olarak
değişmiştir, fakat hastalığın sonlanım noktası üzerine etkisi bilinmemektedir.
Bundan dolayı, KEFKY hastalarında, doku Doppler görüntüleme ile elde edilen sol
atrial iletim zamanı (SEMG) ile kalp yetmezliğine bağlı hastane yatışları
arasındaki ilişkiyi araştırdık.Yöntem: Retrospektif olarak 112 ardışık KEFKY hastası (48 erkek, ortalama yaş 59.9±5)
çalışmaya dahil edildi. KEFKY’li hastalar, kalp yetmezliği semptomu olan,
diyastolik disfonksiyonu izlenen ve EF ≥50% olanlar olarak tanımlandı. Sonlanma
noktası olarak kalp yetmezliğine bağlı hastane yatışı belirlendi, ve bu bilgi
12 ay boyunca retrospektif olarak izlenen hastalardan elde edildi. Hasta
popülasyonu SRMG değerleri baz alınarak istatiksel olarak 3 tertil gruba
ayrıldı. 1. Tertil <22 ms, 2. Tertil 22-42 ms, ve 3. Tertil >42 ms olarak
tanımlandı.Bulgular: Grupların demografik özellikleri arasında büyük oranda anlamlı farklılık
saptanmadı, sol ventrikül boyutları ve EF gruplar arasında benzerdi
(p>0.05). Hastalar 12 ay izlendi, toplam 41 olay kaydedildi. SEMG, olay
gerçekleşen bireylerde diğer bireylere göre daha uzundu. Bunun yanında DDG ile
kaydedilen diyastolik disfonksiyon parametreleri SEMG ile pozitif korelasyon
içindeydi (r=0.627, p<0.001). Bunlara ek olarak, Kaplan-Meier eğrisinde SEMG’i
en uzun olan 3. Tertil grubun, kalp yetmezliği bağlı hastane yatışları ile
yüksek derecede ilişkili olduğu gözlendi (P log rank < 0,001), ve bağımsız
risk faktörü olarak gözlendi (Tertil 3 ile 1 arası tehlike oranı (TO): 18.7,
95% güven aralığı (GA) 2.6-61, p<0.001; Tertil 3 ile 2 arası TO:6.17, 95% GA
1.78-21.2, p<0.001).Sonuç KEFKY olan hastalarda, SAiz kalp yetmzliğine bağlı yatışları öngörebilmede
kolay ulaşılabilir non-invaziv bir yöntem olabilir.
Zehirli Mantar Toksinlerinin Analiz Yöntemleri
Authors: COŞKUN Nuri Cenk , KAYA Ertuğrul
Published: February 2020

Misetizm olarak da bilinen şapkalı mantarlar ile zehirlenme vakaları tıbbi
imkanların çok geliştiği günümüzde bile ölümle sonuçlanabilmektedir. Yaklaşık
100 çeşit zehirlenmeye yol açan mantar türünün arasında yaklaşık 10 tanesi
ölümcül zehirlenmelere yol açabilmektedir. Zehirlenme durumunda bu mantar
toksinlerinin erken tespiti hayati önem taşımaktadır. Bu derlememizde mantar
toksinlerinin hangi yöntemler ile tespit edildikleri tek bir kaynakta
toplanmıştır. Başlıca toksinler olarak; Amatoksinler, Fallotoksinler,
Virotoksinler, Koprin, Giromitrin, İbotenik asit ve Muskimol, Muskarin,
Orellanin, Psilosin ve Psilosibin yer almıştır. Analiz yöntemleri içerisinde
ise; İnce tabaka kromatografisi, Eliza yöntemi, LC-MS/MS, HPLC, Gaz
Kromatografi, LC-QTOF yer almaktadır. Bu derlememizde amaç; özellikle ölümcül zehirlenmeye sebep
olan başlıca şapkalı mantar toksinlerinin analiz metotlarını tek bir kaynakta
toplayarak araştırmacılara güvenilir bir kaynak sağlamaktır.
Development determinants of holiday settlement: Case study of the gmina of Stężyca
Authors: Jażewicz Iwona , Zienkiewicz Aleksandra
Published: February 2020

The article presents the results of research on a specific recreation space – holiday plots. It is an attempt to identify the conditions for the development of holiday settlements, using the example of the gmina of Stężyca situated in the centre of the Kashubian Lake District. The authors indicate the conditions related to the location of holiday plots, as well as the motivations and expectations of their owners. As a result of the study, it was concluded that natural and landscape assets, as well as temporal and spatial accessibility determined the development of the holiday settlement in the gmina of Stężyca. Equally significant factors are family ties and sentiment towards their place of birth.
Motivations for running in men: A comparative analysis of local runners and sports tourists
Authors: Malchrowicz-Mośko Ewa , Poczta Joanna
Published: February 2020

The aim of the study is to to examine the motivations for participating in a half-marathon among two groups of runners, local running in their place of residence and sports tourists, and to evaluate the differences between them. With the increase in the popularity of ‘running tourism’ the question becomes important as it encourages runners to engage in physical activity outside their everyday place of residence. Freyer and Gross’s (2002) four types of motivation for participation in sports events was the basis for the development of the author’s questionnaire. The empirical research (sample size=346) then recognized these motives for participation. The article also presents a review of the literature on such motivations in mass running events. Results indicate that both group of respondents, residents of the place where the half-marathon was organised and sports tourists, have different forms of motivation. The greatest relevance for sports tourists turned out to be motivation for sensation-seeking but for local runners it was the result, and this confirms that sports tourists travel generally in search for strong emotions and sensations.
Przywracając życie w centrum miasta – projekt Oudlajan foodscape w Teheranie
Authors: Hakimian Shiva , Afshar Ali , Kowalczyk-Anioł Joanna
Published: February 2020

Zaproponowany w artykule projekt rewitalizacji dzielnicy Oudlajan, jednej z pięciu dzielnic historycznego centrum Teheranu, odnosi się zarówno do współczesnych potrzeb tego miejsca, jak i jego potencjału. Projekt odwołuje się do irańskiej tradycji miejsc spotkań i obecnych tendencji do spędzania wolnego czasu w mieście oraz kształtowania (projektowania) inkluzywnej przestrzeni miejskiej. Pod względem celu przedstawiony projekt ma charakter aplikacyjny, a biorąc pod uwagę zastosowane metody, jest badaniem opisowo-analitycznym (jakościowym). Artykuł stanowi ponadto głos w debacie na temat turystyki i rewitalizacji ukierunkowanej na tworzenie miejskiej turystycznej przestrzeni smaku (tourism taste-space). Eksponując perskie uwarunkowania w kształtowaniu food-scape, daje ponadto asumpt do prężnie rozwijających się badań nad turystyką kulinarną i miejską przestrzenią gastronomiczną.
Męskie motywacje uczestnictwa w półmaratonie – analiza porównawcza biegaczy lokalnych i turystów sportowych
Authors: Malchrowicz-Mośko Ewa , Poczta Joanna
Published: February 2020

Celem badań było poznanie motywacji do startu w półmaratonie dwóch grup biegaczy: mieszkańców Poznania (sportowców biorących udział w biegu organizowanym w miejscu zamieszkania) i aktywnych turystów sportowych, a także ocena różnic motywacji obu grup. Problem badawczy stał się istotny ze względu na wzrost popularności turystyki biegowej, która jest zachętą dla biegaczy do podejmowania aktywności fizycznej poza ich miejscem zamieszkania. Podział Freyera i Grossa (2002), w którym autorzy wyróżnili cztery typy motywów uczestnictwa w imprezach sportowych, stał się podstawą do opracowania kwestionariusza ankietowego. Badania empiryczne (n = 346) umożliwiły poznanie powodów uczestnictwa w wydarzeniach sportowych. Wyniki wskazują, że obiema grupami respondentów (mieszkańcy Poznania oraz turyści sportowi) kierują różne rodzaje motywacji. Najistotniejszą ich grupą dla lokalnych biegaczy okazały się motywy zorientowane na wynik, a dla turystów sportowych – motywy skierowane na przeżycia, co pozwala sądzić, że turyści sportowi podróżują przede wszystkim w celu poszukiwania silnych emocji i wrażeń.
Martín Tovar y Tovar
Authors: Tejedor Estupiñan Ricardo Alonso
Published: February 2020

Reseña biográfica del artista venezolano
“Memory of Water” Experiments Explained with No Role Assigned to Water: Pattern Expectation after Classical Conditioning of the Experimenter
Authors: Beauvais Francis
Published: February 2020

The “memory of water” experiments suggested the existence of molecular-like effects without molecules. Although no convincing evidence of modifications of water – specific of biologically-active molecules – has been reported up to now, consistent changes of biological systems were nevertheless recorded. We propose an alternate explanation based on classical conditioning of the experimenter. Using a probabilistic model, we describe not only the biological system, but also the experimenter engaged in an elementary dose-response experiment. We assume that during conventional experiments involving genuine biologically-active molecules, the experimenter is involuntarily conditioned to expect a pattern, namely a relationship between descriptions (or “labels”) of experimental conditions and corresponding biological system states. The model predicts that the conditioned experimenter could continue to record the learned pattern even in the absence of the initial cause, namely the biologically-active molecules. The phenomenon is self-sustained because the observation of the expected pattern reinforces the initial conditioning. A necessary requirement is the use of a system submitted to random fluctuations with autocorrelated successive states (no forced return to the initial position). The relationship recorded by the conditioned experimenter is, however, not causal in this model because blind experiments with an “outside” supervisor lead to a loss of correlations (i.e., system states randomly associated to “labels”). In conclusion, this psychophysical model allows explaining the results of “memory of water” experiments without referring to water or another local cause. It could be extended to other scientific fields in biology, medicine and psychology when suspecting an experimenter effect.
Blood Digestion by Trypsin-Like Serine Protease in the Replete Lyme Disease Vector Tick, Ixodes scapularis
Authors: Reyes Jeremiah , Ayala-Chavez Cuauhtemoc , Pham Michael , Sharma Arvind , Nuss Andrew , Gulia-Nuss Monika
Published: February 2020

Ixodes scapularis is the major vector of Lyme disease in the eastern United States. Each active life stage (larva, nymph, and adult) takes a blood meal either for developing and molting to the next stage (larvae and nymphs) or for oviposition (adult females). This protein-rich blood meal is the only food taken by Ixodes ticks and therefore blood digestion is very important for tick survival. Most studies on blood digestion in ticks have shown that the initial stages of digestion are carried out by cathepsin proteases within acidic digestive cells. However, most of these studies have focused on partially engorged ticks. In other hematophagous arthropods, the serine proteases play an important role in blood protein degradation. In this study, we determined transcript expression of four I. scapularis serine proteases with previously characterized roles in blood digestion. RNA interference was used for functional analysis and a trypsin-benzoyl-D, L-arginine 4-nitoanilide assay was used to measure active trypsin levels. An in vitro hemoglobinolytic assay was performed with or without serine protease inhibitor. Our data suggest that trypsin levels increase significantly after blood feeding and peaked in larvae, nymphs, and adults at 3, 1, and 1 day post host detachment, respectively. The knockdown of three previously identified serine proteases by RNAi negatively impacted blood intake, survival, fecundity, levels of active trypsin in the gut and resulted in lower hemoglobin degradation in vitro. A trypsin inhibitor, PMSF, blocked the action of trypsin in the gut extract resulting in 65% lower hemoglobin degradation. We provide evidence of the serine proteases as digestive enzymes in fully engorged, replete females. Our data also demonstrated that in addition to blood digestion, these serine proteases might have a role in blood feeding success in I. scapularis.
In-Stream Energy by Tidal and Wind-Driven Currents: An Analysis for the Gulf of California
Authors: Magar Vanesa , Godínez Victor M. , Gross Markus S. , López-Mariscal Manuel , Bermúdez-Romero Anahí , Candela Julio , Zamudio Luis
Published: February 2020

We analyzed the peak spring tidal current speeds, annual mean tidal power densities (TPD) and annual energy production (AEP) obtained from experiment 06.1, referred as the "HYCOM model" throughout, of the three dimensional (3D), global model HYCOM in an area covering the Baja California Pacific and the Gulf of California. The HYCOM model is forced with astronomical tides and surface winds alone, and therefore is particularly suitable to assess the tidal current and wind-driven current contribution to in-stream energy resources. We find two areas within the Gulf of California, one in the Great Island Region and one in the Upper Gulf of California, where peak spring tidal flows reach speeds of 1.1 meters per second. Second to fifth-generation tidal stream devices would be suitable for deployment in these two areas, which are very similar in terms of tidal in-stream energy resources. However, they are also very different in terms of sediment type and range in water depth, posing different challenges for in-stream technologies. The highest mean TPD value when excluding TPDs equal or less than 50 W/m2 (corresponding to the minimum velocity threshold for energy production) is of 172.8 W/m2, and is found near the town of San Felipe, at (lat lon) = (31.006 -114.64); here energy would be produced during 39.00% of the time. Finally, wind-driven currents contribute very little to the mean TPD and the total AEP. Therefore, the device, the grid, and any energy storage plans need to take into account the periodic tidal current fluctuations, for optimal exploitation of the resources.
Pharmacoinformatics and Molecular Dynamic Simulation Studies Reveal Potential Inhibitors of SARS-CoV-2 Main Protease 3CLpro
Authors: Alamri Mubarak A. , Tahir ul Qamar Muhammad , Alqahtani Safar M.
Published: February 2020

The SARS-CoV-2 was confirmed to cause the regional outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. The 3C-like protease (3CLpro), an essential enzyme for viral replication, is a valid target to compacts SARS-CoV and MERS-CoV. In this research, an integrated library consisting of 1000 compounds from Asinex Focused Covalent (AFCL) library and 16 FDA-approved protease inhibitors were screened against SARS-CoV-2 3CLpro. Top compounds with significant docking scores and making stable interactions with catalytic dyad residues were obtained. The screening results in identification of compound 621 from AFCL library as well as Paritaprevir and Simeprevir from FDA-approved protease inhibitors as potential inhibitors of SARS-CoV-2 3CLpro. The mechanism and dynamic stability of binding between the identified compounds and SARS-CoV-2 3CLpro were characterized using 50 nanoseconds (ns) molecular dynamic (MD) simulation approach. The identified compounds are potential inhibitors worthy of further development as SARS-CoV-2 3CLpro inhibitors/drugs. Importantly, the identified FDA-approved therapeutics could be ready for clinical trials to treat infected patients and help to curb the COVID-19.
Two Things about COVID-19 Might Need Attention
Authors: Jia Xiaodong , Yin Chengliang , Lu Shanshan , Chen Yan , Liu Qingyan , Bai Junfan , Lu Yinying
Published: February 2020

The spread of 2019 novel coronavirus disease (COVID-19) throughout the world has been a severe challenge for public health. The human angiotensin-converting enzyme 2 (ACE2) has a remarkably high affinity binding to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the search for network database and re-analysis of pubic data, we found the level of ACE2 expression in adipose tissue was higher than that in lung tissue, which indicated the adipose tissue might be vulnerable to SARS-CoV-2 as well; the levels of ACE2 expressed by adipocytes and adipose progenitor cells were similar between non-obese individuals and obese individuals, but obese individuals have more adiposes so as to increase the number of ACE2-expressing cells; the expression of ACE2 in tumor tissues posed by five different types of cancers increased significantly compared with that in adjacent tissues. Thus, we suggest that more attentions might be given to obese individuals and the five types of cancer patients during the outbreak of COVID-19.
Improving Altimeter Wind Speed Retrievals Using Ocean Wave Parameters
Authors: Jiang Haoyu , Zheng Hao , Mu Lin
Published: February 2020

Spaceborne altimeters are an important data source for obtaining global sea surface wind speeds (U10). Although many altimeter U10 algorithms have been proposed and they perform well, there is still room for improvement. In this study, the data from ten altimeters were collocated with buoys to investigate the error of the altimeter U10 retrievals. The U10 residuals were found to be significantly dependent on many oceanic and atmospheric parameters. Because these oceanic and atmospheric parameters are inter-correlated, an asymptotic strategy was used to isolate the impact of different parameters and establish a neural-network-based correction model of altimeter U10. The results indicated that significant wave heights and mean wave periods are effective in correcting U10 retrievals, probably due to the tilting modulation of long-waves on the sea surface. After the wave correction, the root-mean-square error of the retrieved U10 was reduced from 1.42 m/s to 1.24 m/s and the impacts of thermodynamic parameters, such as sea surface (air) temperate, became negligible. The U10 residuals after correction showed that the atmospheric instability can lead to errors on extrapolated buoy U10. The buoy measurements with large air-sea temperature differences need to be excluded in the Cal/Val of remotely sensed U10.
Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults
Authors: Kaufman Carolyn S. , Vidoni Eric D. , Burns Jeffrey M. , Alwatban Mohammed R. , Billinger Sandra A.
Published: February 2020

Cerebral blood flow (CBF) decreases across the lifespan, and chronic conditions such as dementia and stroke accelerate this decline. Impaired CBF results in reduced delivery of oxygen and nutrients, which can damage the brain over time. Thus, there is a need to identify lifestyle interventions including diet and exercise to maintain CBF with aging and in the presence of chronic disease. In the present study, we used transcranial Doppler ultrasound to record middle cerebral artery velocity (MCAv), a surrogate measure of CBF, during moderate-intensity exercise in sedentary, cognitively-normal older adults (N = 90). A multiple linear regression model (F(4, 85) = 3.21, p = 0.02) showed self-reported omega-3 supplement use significantly moderated the association between age and mean exercising MCAv in these individuals (p = 0.01). Older age was associated with lower exercising MCAv in the group not taking omega-3 supplements, while exercising MCAv showed no decline with increasing age in the group who reported omega-3 supplement use. These findings suggest omega-3 supplementation may have an important role in the preservation of CBF with aging.
Quantum Cognitive Triad. Semantic Geometry of Context Representation
Authors: Surov Ilya A.
Published: February 2020

The paper describes an algorithm for cognitive representation of triples of related behavioral contexts two of which correspond to mutually exclusive states of some binary situational factor while uncertainty of this factor is the third context. The contexts are mapped to vector states in the two-dimensional quantum Hilbert space describing a dichotomic decision alternative in relation to which the contexts are subjectively recognized. The obtained triad of quantum cognitive representations functions as a minimal carrier of semantic relations between the contexts, which are quantified by phase relations between the corresponding quantum representation states. The described quantum model of subjective semantics supports interpretable vector calculus which is geometrically visualized in the Bloch sphere view of quantum cognitive states.