bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMULATION OF MESENCHYMAL STEM CELL SECRETOME AS ANTIAGING CREAM
Authors: MARLINA  , PRADIFTA REYSA , LUCIDA HENNY , SUDJI IKHWAN RESMALA , SALSABILA HANA NURUL , ELIDA NUR , NAMIRA POPY AYU
Published: February 2023

Objective: Skin aging occurs not only due to age but is influenced by various environmental factors such as lifestyle, pollution, and excessive exposure to UV rays. Secretomes can act as antiaging agents that stimulate collagen biosynthesis naturally in the skin. This study aims to create a cream containing 5% secretome with essential oil, dermatological examination, and Fibroblast Growth Factor (FGF) checking.

Methods: Antiaging efficacy testing involves examination by an expert dermatologist for assessment before and after using the cream. The antiaging impact test criteria include moisture, elasticity, and collagen values. Consequently, the cream shows an antiaging activity.

Results: The antiaging efficacy test revealed increased moisture from 24.375±11.97 to 25.125±7.1; the skin elasticity also increased from 40.375±8.39 to 48.5±9.09 and the collagen value increased from 48.25±13.54 to 56.5±8.63. The result shows that the cream contains a 61.143 pg/ml concentration of FGF using an ELISA kit.

Conclusion: The formula for cream preparations containing 5% secretome with essential oil meets the requirements of cosmetics through several evaluations of the trial. It has an antiaging effect, proven through several tests.
The Life and Death of the Avant-garde on the Battlefield of Rhetoric - and Beyond
Authors: Van den Berg Hubert
Published: February 2023

The following article was originally conceived and presented as a contribution to the "Avant-garde Now?! Fourth Ghent Conference on Literary Theory" at the University of Ghent on March 17, 2005, which addressed the supposed "death of the avant-garde" in art and literary theory.
The Kuleshov Effect and the Death of the Auteur
Authors: Russell Michael
Published: February 2023

The 'Kuleshov Effect' has long been regarded as being both of seminal importance in the development of cinema in the 1920s and yet also as being so ambiguous and difficult to interpret that it has almost become all things to all people. This article shall utilise the Kuleshov Effect as its own palimpsest to try to trace connections between Soviet montage cinema, the politique des auteurs of the French Nouvelle Vague and Barthes' essay on 'The Death of the Author'.
Computer Error: Voices and Translations in Edwin Morgan’s Science Fiction Poetry
Authors: Jones Russell
Published: February 2023

My favourite scene in the movie Independence Day (1996) is when Captain Steven Hiller (Will Smith) knocks out an alien with a single clout, whips out a smart “welcome to Earth”-esque punch line and then lights up a cigar. Sheer. Smith. Action. But what if aliens aren’t all doomsayers, what if all they want is a nice chat? This article will examine the variety of voices in Edwin Morgan’s Science Fiction Poetry (hereby referred to as SFP) and consider their continuities and differences with Morgan’s non-SFP. It will discuss the importance of Morgan as a translator and experimenter of language, highlighting the freedom which SFP allows Morgan as a poet.
The Problem of Ideology
Authors: Gani Jasmine
Published: February 2023

This article discusses the role of ideology in International Relations. It seeks to rectify potential weaknesses in any ideological analysis using two approaches. Firstly, applying a more thorough and precise definition of ideology. Secondly, identifying the historicity and complexities within an ideology, distinguishing between core and peripheral principles, and their shifting interaction over time.
He Said/She Said: Truth-Telling and #MeToo
Authors: Gilmore Leigh
Published: February 2023

"He Said/She Said: Truth-Telling and #MeToo" analyses how the conversation about sexual violence changed when millions of women worldwide raised their voices to say “Me Too.” It historicizes the #MeToo movement within feminist activism in communities of colour around sexual assault advocacy and in relation to Anita Hill's testimony in 1991 that Clarence Thomas sexually harassed her. The #MeToo moment offers a clear representation of the scale of sexual violence and presents a vivid example of the power of testimony to conjure a scene of witness through the power of truth-telling. Leigh Gilmore argues that truth-telling is dynamic and that survivor speech in the form of #MeToo has disrupted the routine minimization of women's accounts of harm into the "He said/She said" pattern.
The Effect Of Intellectual Capital Efficiency On Company’s Market Value With Company’s Financial Performance As Intervening Variables
Authors: Sujati Khrisna Adisatya , Januarti Indira
Published: February 2023

The purpose of this study is to investigate empirically the relation between the company’s intellectual capital efficiency and company’s market valuation with company’s financial performance as intervening variables. This study using data from the Indonesia listed service companies. The samples of this study was 109 companies. Pulic’s Value Added Intellectual Coefficient (VAICTM) used as the efficiency measure of company’s intellectual capital. The authors construct regression models to examine the relationship between company’s intellectual capital efficiency and company’s market valuation and explore the relation with company’s financial performance as intervening variables. The results support the hypothesis that company’s intellectual capital has an affect on company’s market valuation. In addition, the authors found that company’s financial performance has a role as full mediator on the relation between the company’s intellectual capital efficiency and company’s market valuation. This study results can be used as a reference for companies’ management to improve their efficiency of the intellectual capital so the company's financial performance and value can be improved.
Does CEO’s Financial Decision Able To Improve Firm Value Of Consumer Good Industry
Authors: Sari Widya , Waruwu Darni , Purba Ewnike
Published: February 2023

The purpose of this study was to determine the effect of PER, DER, and DPR financial decisions with CEO as a moderating variable on firm value in the consumer goods industry in 2015-2019. The researcher uses a quantitative approach with quantitative descriptive research and explanatory research. Collecting sample data using purposive sampling method, with the help of software SPSS to do testing statistic analysis. From the results of this study the researchers found that partially, investment decisions have a positive influence in increasing firm value, with the CEO having a positive influence on investment decisions in increasing firm value. And simultaneously Investment Decisions, Funding Decisions, and Dividend Decisions affect the value of the company, with the CEO influencing the three financial decisions on the value of consumer goods industry companies listed on the Indonesia Stock Exchange. with the CEO who has a positive influence on financial decisions on firm value, then it becomes a difference to previous research that has been done on firm value.
Does Environment Uncertainty Affect Earnings Management?
Authors: Surbakti Gloria Putri Naftali , Sudaryati Erina
Published: February 2023

This research is aimed to examine the effect of environment uncertainty towards earnings management. This study is a quantitative study with sample all of manufacturing companies that are listed in Indonesian Stock Exchange (IDX) from period 2013 -2018 and publish the financial statement consecutively during period 2013-2018. The sample is selected by using purposive sampling techniques with total of 455 companies. This study uses secondary data that derived from the financial statements of manufacturing companies during that period. By using regression analysis and SPSS in processing research data, the study finds that environment uncertainty has positive impact to financial distress. It indicates when companies are facing an environment uncertainty, it will impact to their performance especially financial performance which leads to the financial distress condition. Companies in higher financial distress condition are more likely to manage their earnings by using earnings management which are measured by discretionary accruals. This research is useful for investor as one of consideration before making financial decision especially when companies are in uncertain environment.
Creation Of Auditor Loyalty: Improving Competence, Quality Of Work And Job Satisfaction
Authors: Muttaqin Galih Fajar , Machfuzhoh Asih , Fazri Edward
Published: February 2023

The purpose of this study is to investigate how auditor competence can affect the work quality and job satisfaction of an auditor which also has an impact on increasing auditor loyalty in carrying out their responsibilities as auditors. This study uses a quantitative method by distributing questionnaires to auditors who work at KAPs domiciled in Banten, Jakarta and Answers. The sample in this study was 170 auditors. Data processing is carried out with a Structural Equation Model (SEM) approach using Partial Least Square (PLS) software. PLS is a component-based or variance-based structural equation (SEM) model. Validity test was carried out using Partial Least Square (PLS) software. The results of this study indicate that the auditor competence, work quality, and job satisfaction can increase the loyalty of auditors working at Public Accounting Firms in Indonesia. This research has implications for the development of audit research, especially the behavior of public accountants, which until now has not been much research that focuses on the behavior of auditors in public accounting firms. In addition, the results of this study can also be used as a reference in determining policies by stakeholders, both regulators and leaders of Public Accounting Firms
Moderating Effect Of Executive Characteristics In The Effect Of Transfer Pricing On Tax Avoidance
Authors: Amanda Verna Budi , Carolina Verani
Published: February 2023

Tax avoidance is commonly considered as an act which can make a country suffering a great loss. Transfer pricing scheme is one of the most common activity that usually multinational enterprises do regarding to the tax avoidance. The aims of this research are to test and find an emphirical evidence regarding to the effect of transfer pricing on tax avoidance and the effect of transfer pricing on tax avoidance with executive characteristics as a moderate variable. The population of this research is all of the manufacturing companies that are listed in Indonesia Stock Exchange (IDX) during the years of 2017-2019. This research sample is determined by the purposive sampling technique. The method of analysis used in this research is regression analysis method. The results shows that transfer pricing has an effect to tax avoidance and executive characteristic can positively moderate the effect of transfer pricing on tax avoidance.
Influence of Halal Certification on Innovation and Financial Performance
Authors: Urumsah Dekar , Puspitasari Dyah Ayu
Published: February 2023

This research is to empirically examine the influence of halal certification on innovation and financial performance by adopting Resource Based View (RBV) theory. The data used were the financial statements of food and beverage corporates listed at Indonesian Stock Exchange of 2015-2018 period. The analysis method employed was multiple linear regression using SPSS. The results show that halal certification significantly and positively affects financial performance. Similarly, innovation also results in positive and significant effect on financial performance, and halal certification positively and significantly affects innovation and financial performance. A number of implications are catered by this research, such as theoretical contribution toward the existing literature related to food corporations in Indonesia. This is expected to be a reference for the study on halal food corporation in Indonesia, as well as to provide knowledge of the improvement of financial performance and innovation through halal certification for food corporate management.
performance and innovation through halal certification for food corporate management.
The Moderation Of Intellectual Capital And Information Asymmetry In The Effect Of Voluntary Reporting On Stock Return
Authors: Wardatul Jannah  , Saraswati Erwin , Ghofar Abdul
Published: February 2023

Abstract
Voluntary reporting and intellectual capital are important instruments for the provision of information to investors. The information increases investment interest and ultimately affects stock return. This study examines the effect of voluntary reporting on stock return with the moderation of intellectual capital and information asymmetry. The sample of this study is 225 observations from 45 financial and banking companies listed on the Indonesia Stock Exchange during the period of 2015-2019. Financial and banking sector has an important role for companies in other sectors in providing capital and a sense of security for their assets. Multiple regression method and MRA applied in this study have come to findings that voluntary reporting increases stock return, that intellectual capital strengthens the relationship between voluntary reporting and stock return, and that information asymmetry has no effect on the relationship between voluntary reporting and stock return as companies begin to respond to the importance of voluntary reporting to reduce information asymmetry.
Political Correspondence And Public Pressure: Study Of Environmental And Water Performance
Authors: Fidiana Fidiana
Published: February 2023

This study aims to examine public pressure and political correspondence on environmental and water disclosures. Specifically, based upon a panel dataset of 114 Indonesian listed firms operating in highly risk water industries (Miscellaneous Industry, Basic Industry, Consumer Goods Industry, Agriculture, and Mining) during 2017–2019, we use regression models to analyze the relationships between water disclosure based on the GRI 300 (environmental) and 303 (water) guidelines and public pressure and political-connected firms. Our empirical results show the positive influence of public pressure and environmental and water disclosure. Meanwhile, political correspondence has no bearing on water-related disclosures, implying that every firm undertakes the disclosure without regard for political ties. The digital era has changed the supervisory mechanism to be tighter so that each issuer cannot take shelter in political ties to ignore their business responsibilities. The results of this study have important policy implication, particularly regarding the commitment to water-related reporting, the amount of disclosure remains low, which could be due to a lack of demand from stakeholders or a lack of need for water reporting to provide legitimacy. This suggests that firms will enhance their water commitment using GRI standards and disclose more detailed in financial statements.
Dampak Inovasi Sistem Pembayaran Terhadap Nilai Pemegang Saham Bank Dan Pengecer
Authors: Muditomo Arianto , Syaukat Yusman , Andati Trias , Hasanah Nur
Published: February 2023

Artikel ini bertujuan meneliti respon pasar modal terhadap penerapan Gerbang Pembayaran Nasional Indonesia, untuk membuktikan bahwa interkoneksi dan interoperabilitas transaksi di merchant akan meningkatkan penerimaan kartu debit dan uang elektronik pada sisi permintaan, mendorong lebih banyak transaksi di merchant dan mengurangi biaya pertukaran sehingga akan meningkatkan pendapatan pedagang pada sisi penawaran. Hasil penelitian menunjukkan bahwa pasar modal merespon positif dampaknya terhadap kinerja saham bank penerbit tetapi memberikan respon negatif terhadap saham pengecer. Penelitian ini melengkapi literatur penelitian event-study terdahulu di pasar modal Indonesia serta memberikan literatur baru tentang dampak model pasar dua sisi pembayaran ritel elektronik dari sudut pandang eksternalitas jaringan antara bank penerbit dan pengecer. Penelitian ini dilakukan hanya pada pasar modal Indonesia dan hanya pada implementasi kartu debit GPN.
Determinan Manipulasi Akrual Dalam Pelaporan Keuangan Pemerintah Daerah
Authors: Handayani  , Darwanis  , Abdullah Syukriy
Published: February 2023

This study aims to determine the effects of government size, fiscal capacity, fiscal distress, and legislature size on accrual manipulation in local government financial reporting. The study was conducted on 23 local governments in Aceh with data analysis using multiple linear regressions. The data is extracted from audited financial reports of the local governments for the period 2016-2020. This study uses the Modified Jones Model to measure the manipulation of accruals. The results show that the government size and fiscal distress have a negative effect on accrual manipulation, legislature size has a positive effect on accrual manipulation, and fiscal capacity have no effect on accrual manipulation. These results indicate that the accrual manipulation in financial reporting can occur due to discretionary policies carried out by local government officials with the aim of making their financial performance look good.
Determinan Pencegahan Kecurangan Dalam Alokasi Dana Desa
Authors: Susandya Anak Agung Putu Gede Bagus Arie , Putra M Doni Permana , Bagiana I Kadek , Cahyani Meita Risma , Aristanti Ida Ayu Putu Meita Puspa
Published: February 2023

The purpose of this study is to find empirical evidence regarding the effect of competence, morality, integrity, internal control and organizational culture on the fraud prevention in allocation of village funds. The sample in this study are obtained from 148 respondents from village officials in Denpasar. Multiple regression analysis is used to answer the hypothesis in this study. The results of the study find that competence, morality, internal control and organizational culture has a positive effect on fraud prevention. This finding indicates that village officials have responsibilities and want to apply the good village governance principles, transparent, and accountable. Integrity was not able to minimize the occurrence of fraud. The allocation of village funds has a vulnerability in its allocation in infrastructure development in the village. This study uses organizational culture as novelty because there are few articles that examine the allocation of village funds with organizational culture. For further research is expected to examine the characteristics of village heads that can affect the level of fraud prevention in village funds. The village head as the user of village funds is expected to be transparent and responsible in the allocation of village funds.
Investigating In Disclosure Of Carbon Emissions: Influencing The Elements Using Panel Data
Authors: Hidayat Imam , Ismail Tubagus , Taqi Muhamad , Yulianto Agus Solikhan
Published: February 2023

This study aims to examine the effect of media exposure, environmental performance, profitability, company size on disclosure of carbon emissions. The research population includes all companies on the Indonesia Stock Exchange (IDX) for the 2017-2021 period. The sample in the study was determined by purposive sampling technique and 18 companies were found over a period of 5 years, resulting in 90 research samples. The analytical method used is Panel Data Regression Analysis. The results of the study show that media exposure, environmental performance and company size have a positive effect on disclosure of carbon emissions, while profitability has no effect on disclosure of carbon emissions. The limitation of this research is that this research only focuses on manufacturing companies that have been listed on the Indonesia Stock Exchange (IDX), so that it cannot describe the condition of the population of all companies in Indonesia so that it can provide different results if carried out in different industries. The results of this study are expected to pay more attention to the company's environmental impact by increasing disclosure of environmental information related to greenhouse gas emissions because it can be added value to the company for stakeholders or investors.
Institutional Pressure And Social Entrepreneurship Orientation: Their Impact On The Performance Of Social Enterprises
Authors: Basri Yesi Mutia , Taufik Taufeni , Yasni Hariadi , Putri Rosalina Indah
Published: February 2023

Social enterprises are organizations that have economic and social goals. However, the performance of the social enterprise is still not satisfactory. In this study, the researchers examined one of the social enterprises that is developing in Indonesia, namely Village Owned Enterprises (BUMDes). This study aim to evaluates the effect of institutional pressure and social entrepreneurial orientation on the social performance of the social enterprise. It looks at the impact of social performance on the social enterprise's financial performance. The population in this study is social enterprise BUMDes in Bengkalis Regency with a stratified random sampling technique. Respondents in this study were BUMDes managers. Data collection was carried out by sending questionnaires directly to BUMDes managers. A total of 103 respondents participated in this study. The data that has been analyzed using Warp PLS shows that institutional pressure and social entrepreneurial orientation have a positive effect on social performance, and have an effect on improving financial performance. This research has implications for supporting institutional theory and improving BUMdes performance.
Corruption Disclosure: Can Evidence Competence Intervene In The Impact Of Forensic Auditor Professionalism And Expertise?
Authors: Reschiwati Reschiwati , Nasrullah Nasrullah , Amrizal Amrizal
Published: February 2023

This study aims to examine the effect of the professionalism and expertise of forensic auditors on corruption disclosure with evidence competence as an intervening variable. Respondents in this study were forensic auditors at the Main Examiner of State Finance I BPK RI and the Deputy for Investigation at the DKI Jakarta Province BPKP Representative. The sample selection used the convenience method . The research instrument is a questionnaire. The number of answers that can be processed is as much as 80 respondents. The data analysis method was Partial Least Square. The results of the study show that the professionalism and expertise of the forensic auditor influences both the competence of evidence and the disclosure of corruption. Evidence competency influences disclosure of corruption and is proven to be able to intervene both the professional influence of the forensic auditor and the influence of the forensic auditor's expertise on corruption disclosure. This study has implications that the forensic auditor in carrying out audit procedures cannot be separated from the professionalism and expertise possessed. The auditor must produce competent audit evidence to give investigators confidence about witness testimony, expert testimony, letters, instructions, and defendant statements.
A Comprehensive Analysis of Antimicrobial Agents Used in Surgical Prophylaxis in Clean Case A Review
Authors: SHAMS ABU RAIHAN , AJMAL MOHD , JAIN CHARUL , SINGH MULAYAM , SHAMSI RAFAT JAHAN , ANIS PARWEZ , PERWEEN SADIYA
Published: February 2023

Introduction: A global health issue known as antimicrobial resistance
(AMR) transcends geopolitical boundaries. Surgical antibiotic
prophylaxis (SAP) is the process of administering antimicrobial to treat
contagions as a preventative measure, avoid them before, during, and
after surgery. During surgery or after surgery there may be chances of
acquiring infection. Infection at the surgical site is one such
complication known as surgical site infection (SSI). It is one of the
problems that reoccur the most frequently in clinical setting. Surgical
site infection is described as an infection that develops with in thirty
days of surgery and might be deep, affecting the organs reached during
surgery, or superficial, involving only the skin. SSIs are occasionally
the leading cause of death following surgical treatments. So, to reduce
these types of complication we use surgical antibiotic prophylaxis.
Methods: PubMed, Google Scholar, ResearchGate, and healthcare system
evidence were searched from 2005 to 2022 for systemic review that was
published in the English language. Result: Data were extracted for all
primary outcomes, 38 reviews were included, and review quality was
evaluated using AMSTAR 2. The most often reported administration of
antibiotic, timing, drug class, and primary result, respectively, were
preoperative antibiotic administration, first generation cephalosporin
usage, and surgical site infection (SSI). Results indicate that, in
comparison to a placebo or no SAP, SAP may, on average, decrease SSIs.
The finding showed that postoperative SAP did not differ significantly
from intraoperative SAP in reducing SSI. Keywords: Surgical Antibiotic
Prophylaxis (SAP), Surgical Site Infections (SSIs), Wound Classification
Influence of non-irradiated surface optical absorber on temperature gradient induced by photothermal effect in a thin film
Authors: Miletic Vesna , Popovic Marica , Galovic Slobodanka , Markushev Dragan , Kostic Ljiljana , Nesic Miroljub
Published: February 2023

This paper presents the model of surface temperature variations, resulting
from the photothermal effect induced in a ?thin film ? highly absorbing
surface layer? structure, where the thin film is irradiated. The influence
of the optical absorption coefficient and sample thickness on the induced
temperature gradient is analyzed. It is shown that, depending on the product
of these parameters (optical absorbance) in the described structure, the
phenomenon of inverse temperature gradient can occur, further influencing
the direction and the magnitude of thermoelastic displacement.
Dietary nitrate and corresponding gut microbiota prevent cardiac dysfunction in obese mice
Authors: Petrick Heather L. , Ogilvie Leslie M. , Brunetta Henver S. , Robinson Avery , Kirsh Aleah J. , Barbeau Pierre-Andre , Handy Rachel M. , Coyle-Asbil Bridget , Gianetto-Hill Connor , Dennis Kaitlyn M.J.H. , Loon Luc J.C. van , Chabowski Adrian , Schertzer Jonathan D. , Allen-Vercoe Emma , Simpson Jeremy A. , Holloway Graham P.
Published: February 2023

Impaired heart function can develop in diabetic individuals in the absence of coronary artery disease or hypertension, suggesting mechanisms beyond hypertension/increased afterload contribute to diabetic cardiomyopathy. Identifying therapeutic approaches that improve glycemia and prevent cardiovascular disease are clearly required for clinical management of diabetes-related comorbidities. Since intestinal bacteria are important for metabolism of nitrate, we examined if dietary nitrate and fecal microbial transplantation (FMT) from nitrate-fed mice could prevent high-fat diet (HFD)-induced cardiac abnormalities. Male C57Bl/6N mice were fed an 8-week low-fat  diet (LFD), HFD, or HFD+Nitrate (4mM sodium nitrate). HFD-fed mice presented with pathological left ventricular (LV) hypertrophy, reduced stroke volume and increased end diastolic pressure, in association with increased myocardial fibrosis, glucose intolerance, adipose inflammation, serum lipids, LV mitochondrial reactive oxygen species (ROS), and gut dysbiosis. In contrast, dietary nitrate attenuated these detriments. In HFD-fed mice, FMT from HFD+Nitrate donors did not influence serum nitrate, blood pressure, adipose inflammation, or myocardial fibrosis. However, microbiota from HFD+Nitrate mice decreased serum lipids, LV ROS, and similar to FMT from LFD donors, prevented glucose intolerance and cardiac morphology changes. Therefore, the cardioprotective effects of nitrate are not dependent on reducing blood pressure, but rather mitigating gut dysbiosis, highlighting a nitrate-gut-heart axis. 
Managing Svalbard Tourism: Inconsistencies and Conflicts of Interest
Authors: Hovelsrud Grete K. , Olsen Julia , Nilsson Annika E. , Kaltenborn Bjørn , Lebel Julien
Published: February 2023

The Svalbard Archipelago has experienced a rapid increase in tourism-related activities over the past few decades. The Norwegian Government’s ambition to develop the Archipelago’s tourism industry offers multiple socio-economic opportunities. The development and scope of these tourism activities is affected by a complex governance system that entails strict environmental regulation and preparedness considerations. To understand the balance of goals across the national and international policy levels, we have mapped, reviewed, and analyzed the national and international regulations and agreements that affect tourism activities on Svalbard. The document analysis reveals the framework of natural and environmental consideration, access to areas and passage, requirements for organized outdoor activities, and regulatory tools. We discovered conflicts and internal inconsistencies in the way that Svalbard tourism has developed. It has been shaped by both economic growth and environmental preservation, without any specific business development objectives and goals or acceptable limits of environmental and social change in place. For tourism stakeholders, this might complicate any rational assessment of the balance between economic development and environmental status. The challenges we have identified are specific to Svalbard, but are likely to be similar in many other Arctic locations involved in tourism.
Strengthening leadership skills through embodied learning in Early Childhood Teacher Education
Authors: Meyer Grete Skjeggestad , Reigstad Ingunn
Published: February 2023

This research paper presents a qualitative, single case study based on empirical material collected duringa course in microteaching in Norwegian Early Childhood Teacher Education. Our research question is: What leadership skills do students develop in Early Childhood Teacher Education through embodied learning with microteaching?
We aim to increase research-based knowledge of interdisciplinary and student-active leadership learning, using drama and pedagogy. This paper reports an analysis of last-year-students’ experiences of pedagogical leadership, captured through video documentation, written reflection assignments, and written evaluative assignments. We use thematic analysis, and find three main themes: embodied expression, embodied reflection, and embodied collaboration.
Norwegian ECEC teachers seem to lack competence on leadership (Ministry of Education, 2018). Our research contributes on how to strengthen the students’ leadership skills. Students express that through embodied learning they have strengthened their self confidence, ability for reflection, creativity, and giving and receiving feedback, which are important leadership skills. The students report that their embodied experience has given them embodied learning.
Regulatory considirations for cellular products development: how to accelerate the marketing authorisation in Russia and EAEU
Authors: Niyazov R. R , Deev R. V , Dranitsyna MA. A , Yasniy I. E , Gavrishina E. V , Vasiliev A. N
Published: February 2023

The environment for the development of products containing live cells as an active substance is being set up in Russia for several years. However, the acceptable regulatory framework, which would have allowed to develop and place cell therapy products on the market, complying with international requirements for safety, efficacy, and quality, has not been yet established. Moreover, in addition to the national legal framework, the Eurasian Economic Union regulatory model has emerged that introduces in parallel a more straightforward pathway for the development and clinical use of this important medical product category. In this paper we address the domestic and Eurasian regulatory systems for products containing live cells as an active ingredient and suggest certain possible approaches to support this area of biotechnology.
Genetic analysis of patients with hypertrophic cardiomyopathy
Authors: Dementyeva E. V , Vyatkin Yu. V , Kretov E. I , Elisaphenko E. A , Medvedev S. P , Zakian S. M
Published: February 2023

Hypertrophic cardiomyopathy is one of the most common cardiovascular pathologies. In most cases, the disease is caused by mutations in genes encoding for sarcomeric proteins. However, high genetic heterogeneity of hypertrophic cardiomyopathy makes it difficult to interpret results of patients' genetic studies. The aim of this study is to check if hypertrophic cardiomyopathy in 15 patients suffering from the disease is due to genetic causes. In the course of genetic analysis, a known pathogenic mutation p.Gln1233Ter in MYBPC3 causing hypertrophic cardiomyopathy was found only in one patient. In six patients, mutations with uncertain clinical significance were identified in hypertrophic cardiomyopathy-associated genes LDB3, MYBPC3, MyH7, MYL2, and MyPn. Three of the mutations, p.Ile730Asn in LDB3, p.Asn515del in MYBPC3, p.Arg955Trp in MYPN were found for the first time in association with hypertrophic cardiomyopathy. In two patients, novel mutations, p.Ser478Trp in MyBpC3 and p.Asn989Ile in MYPN, were identified. Thus, hypertrophic cardiomyopathy may be accounted for by genetic causes in 8 patients more but the role of these mutations in the disease development needs to be clarified.
Complex assessment of a plasmid DNA mechanism of action in development of gene-activated materials
Authors: Bozo I. Y , Mavlikeev M. O , Titova A. A , Bilyalov A. I , Indeykin F. A , Pulin A. A , Eremin I. I , Komlev V. S , Isaev A. A , Deev R. V
Published: February 2023

The number of studies related with gene-activated matrices is increasing annually; the first-in-class product has been already implemented into clinical practice for bone grafting indications. Considering specificity of the gene-activated matrices mechanism of action determined by gene constructs, there is a demand to standardize the methods allowing to characterize all the stages of biological action in vivo. Here, using on the example of a gene-activated hydrogel consisting of type I collagen and plasmid DNA with the vascular endothelial growth factor gene (VEGF165), the main steps of the plasmid DNA mechanism of action were confirmed by various methods. For this, a fluorescent Cy3, reporter plasmid DNA with the firefly luciferase gene (Luc), RT-PCR and ELISA, immunohistochemical study with antibodies to CD31 were used. The results were compared with the other scientific papers, some recommendations were formulated to determine a minimally required list of studies for the development of gene-activated materials.
Legal boundaries of research to create inherited modifications of the human embryo genome in the people's Republic of China
Authors: Blinov A. G , Gerasimov A. M , Gerasimova E. A
Published: February 2023

The growing impact of assisted reproductive technologies on the quality of human life and health has required the leading countries to establish a legal framework in the sphere of biomedical research. The question of the legitimacy of genetic modification of human embryos for reproductive purposes is particularly acute. The public and the scientific community give a controversial ethical assessment of the prospects for human DNA editing to new generations. This fact arouses interest in the legal environment of countries that have achieved some success in the sphere of medical innovation. The People's Republic of China was one of the first countries to declare successful genetic research with human embryos. The purpose of this work is to identify the legal boundaries of research to create inherited modifications of the human embryo genome in China. The methodology used in the research: dialectical method as a universal tool of cognition with method of dogmatic (formal-legal) analysis, discourse analysis and case study. By using these methods managed to structure and meaningfully disclose the regulatory framework of the PRC, regulating genetic research of the human embryo for reproductive purposes. The legal documents regulating preclinical and clinical embryo genome studies are summarized. The particular attention is paid to legal precedent of human DNA editing.
On the current status and prospects for the development of clinically significant cell technologies: do not interfere!
Authors: Mentkevich G. L , Isaev A. A , Prikhodko A. V , Potapov I. V , Deev R. V
Published: February 2023

The material contains a conversation between doctors-developers, administrators and clinicians on the introduction of banking of umbilical cord blood and umbilical cord cells into healthcare practice. The data on clinical studies conducted in the world to assess the safety and effectiveness of the use of umbilical cord blood cells are presented.
Role of the immune system in COVID-19 pathomorphogenesis
Authors: Studenikina E. D , Ogorelysheva A. I , Ruzov Ya. S , Khabibullin I. R , Samorukova I. Z , Chernova O. N , Asaulenko Z. P , Mavlikeev M. O , Budnicova I. N , Nikolaev V. I , Vinnichuk S. A , Deev R. V
Published: February 2023

The new coronavirus infection is a highly contagious infection caused by the SARS-CoV-2 virus that has become a global public health problem. The pathogenesis of this virus has not yet been clearly understood, the principles of hyperinflammatory immune response in critically ill patients, which leads to acute respiratory distress syndrome and multiple organ failure, innate and adaptive immune responses in the process of structuring the data under study. The interaction of the virus and a macroorganism includes 4 stages: infection, dissemination, cytokine storm, pulmonary fibrosis. This review analyzes the predictors of infection, its possible pathogenesis, the immune response of the macroorganism, as well as the histological characteristics of damage to immune organs; shows receptors for SARS-CoV-2 (ACE2, TMPRSS2) in some organs.
Membangun Karakter Profil Pelajar Pancasila Berlandaskan Tri Hita Karana dalam Perspektif Kehidupan Global
Authors: Rai Ida Bagus , Sila I Made , Brata Ida Bagus , Sutika I Made
Published: February 2023

Kondisi masyarakat Indonesia pada saat ini telah menunjukkan adanya suatu distorsi pada nilai–nilai keadilan dan kemanusiaan. Realitas yang terjadi sangat paradoks antara harapan dan kenyataan, dimana manusia kehilangan kendali untuk mencari hubungan yang harmonis. Diperlukan landasan yang kuat untuk mencapai hubungan yang harmonis dalam hal ini dikonseptualisasikan dalam ajaran Tri Hita Karana. Tujuan penelitian ini adalah untuk menganalisis profil Pelajar Pancasila yang berlandaskan pada konsepsi kehidupan Tri Hita Karana sebagai pedoman dan nilai kearian lokal masyarakat Bali. Penulisan artikel ini merupakan studi pustaka dimana tema atau topik dilakukan dengan mengkaji teori yang berkaitan dengan tema atau topik terkait karakter profil pelajar dan Tri Hita Karana. Proses pengumpulan data studi literature meliputi editing, organizing, dan finding. Hasil penelitian ini penunjukan bahwa proses pendidikan karakter melalui konsep pengajaran Tri Hita Karana di sekolah terdapat implikasi terhadap pembuatan Karakter atau ketahanan individu partisipan didik ataupun siswa. Ajaran Tri Hita Karana menekankan bahwa umat manusia selalu berupaya untuk mewujudkan kehidupan yang harmonis dengan alam dan lingkungannya.
Everybody’s talking about equity, but is anyone really listening?: The Case for Better Data-Driven Learning in Health Systems
Authors: Lee-Foon Nakia , Reid Robert
Published: February 2023

Data collection, analysis, and data driven action cycles have been viewed as vital components of healthcare for decades. Throughout the COVID-19 pandemic, case incidence and mortality data have consistently been used by various levels of governments and health institutions to inform pandemic strategies and service distribution. However, these responses are often inequitable, underscoring pre-existing healthcare disparities faced by marginalized populations. This has prompted governments to finally face these disparities and find ways to quickly deliver more equitable pandemic support. These rapid data informed supports proved that learning health systems (LHS) could be quickly mobilized and effectively used to develop healthcare actions that delivered healthcare interventions that matched diverse populations' needs in equitable and affordable ways. Within LHS, data are viewed as a starting point researchers can use to inform practice and subsequent research. Despite this innovative approach, the quality and depth of data collection and robust analyses varies throughout healthcare, with data lacking across the quadruple aims. Often, large data gaps pertaining to community socio-demographics, patient perceptions of healthcare quality and the social determinants of health exist. This prevents a robust understanding of the healthcare landscape, leaving marginalized populations uncounted and at the sidelines of improvement efforts. These gaps are often viewed by researchers as indication that more data is needed rather than an opportunity to critically analyze and iteratively learn from multiple sources of pre-existing data. This continued cycle of data collection and analysis leaves one to wonder if healthcare has a data problem or a learning problem.
In this commentary, we discuss ways healthcare data are often used and how LHS disrupts this cycle, turning data into learning opportunities that inform healthcare practice and future research in real time. We conclude by proposing several ways to make learning from data just as important as the data itself.
The Mental Workload Of Nurses In The Role Of Nursing Care Providers
Authors: Destiani Witri , Mediawati Ati Surya , Permana Ryan Hara
Published: February 2023

The responsibility of nurses as nursing care providers is a factor that affects the mental workload. The mental workload of nurses as caregivers who have to work and interact with patients professionally for 24 hours would arise. It may because of continuous adaptation of time constraints in providing nursing care for 24 hours, unclear job demands, limited ability, lack of motivation and mood, and the psychological burden of the nurse. This study aimed to describe the mental workload in carrying out their role as the nursing care provider at eight inpatient wards, Sumedang public hospital. This research applied descriptive quantitative design. The mental workload was measured using the NASA-TLX instrument. The samples were 94 who works inpatient rooms, they were randomly selected through cluster sampling techniques. Analysis of the data was descriptive analysis. The results of the study showed that 67% of nursing nurses had a mental workload that was in the role of providing nursing care. Nurses have a high mental workload in providing nursing care in special surgical wards (53.8%) and child wards (50%). It is recommended that hospitals evaluate the work system of nurses to examine the physical, psychological and behavioral changes that occur to nurses. It is expected that nurses show good performance in carrying out their role as nursing care providers.
Tingkat Kecanduan Game Online pada Mahasiswa Fakultas Keperawatan
Authors: Pratama Ruby Anggara , Widianti Efri , Hendrawati Hendrawati
Published: February 2023

Ilmu pengetahuan dan teknologi pada masa kini berkembang dengan pesat salah satu jenisnya berupa game online, semakin sering seseorang memainkannya dapat menjadi kecanduan dan pada dewasa awal respon emosi sering menghindar dari masalah dengan cara bermain game online. Penelitian ini bertujuan untuk mengetahui tingkat kecanduan game online pada mahasiswa Fakultas Keperawatan Universitas Padjadjaran PSDKU. Penelitian ini merupakan deskriptif kuantitatif dengan Teknik total sampling pada130 orang mahasiswa. Alat ukur menggunakan GAIA terdiri dari 23 item dengan skala Likert. Analisa data menggunakan distribusi frekuensi. Hasil penelitian menunjukkan tidak kecanduan 62 mahasiswa (47,7%), kecanduan ringansedang 34 mahasiswa (26,2%), dan kecanduan berat 34 mahasiswa (26,2%). Jika kecanduan tidak ditangani dengan benar dapat menimbulkan tidak terkontrolnya diri karena tidak mampu mengurangi waktu bermain sehingga hubungan sosial dan tugas menjadi terhambat. Saran kepada institusi pendidikan agar mengurangi pembelajaran kelas besar karena dapat di contoh dari angkatan sebelumnya. untuk dilakukanya seminar atau pendidikan kesehatan tentang bahaya dan masalah apa yang akan muncul dari kecanduan game, dikarenakan ingkat kecanduan pada mahasiswa masih dalam kategori tidak kecanduan namun hal itu bisa menyebabkan peningkatan kecanduan game online, untuk dosen wali agar memberi arahan kepada mahasiswanya terhadap pemanfaatan waktu khusunya dalam bermain game online pada saat perwalian di awal semester.
Correlation of Media and Parents Role to Adolescent Sexual Behavior
Authors: Mulya Adelse Prima , Lukman Mamat , Yani Desy Indra
Published: February 2023

Adolescent sexual behavior affected by many factors such as the lack of parents' role in supervising Adolescents and information from electronic media that is less educative so that high school Adolescents in Bandung are encouraged to engage in risky behavior. The purpose of this study is to see how correlations media roles and a parent’s role with adolescent sexual behavior in an SMA Bandung. This research was quantitative, used an analytic method with a cross-sectional approach. The population in this study was all students of class X and XI in an SMA Bandung, amounting to 580 people. Samples were count using an estimated absolute precision sample formulas with a total of 246 students. The data collected use three pieces of the questionnaire including Adolescent sexual behavior questionnaire, media role, and parent’s role questionnaires. All of them were passed reliability and validity checked. Data were analyzed using Chi-square. The results showed, the role of parents has a correlation with adolescent sexual behavior and also the role of Media, it has correlation too. It is recommended to school staff, parents, and high school students, unwell adolescent behavior is our responsibility together. Schools can make regulations regard this, parents can increase the control to them. Besides, it can enhance the adolescent’s health, and it would be a better future for them.
Prevalence and Risk Factors of Iron Deficiency Anemia among Postpartum Women
Authors: Darmawati Darmawati , Syahbandi Syahbandi , Fitri Aida , Audina Masyithah
Published: February 2023

One of the problems that contributes to the highest number of maternal mortality and morbidity is postpartum anemia. It is estimated that 50–80% of women experience anemia within 48 hours after giving birth. Globally, the commonest cause of anemia is iron deficiency. In Aceh, study on anemia in the postpartum period is still rare and requires to get more attention. This study aims to identify the prevalence of anemia among postpartum women and the associated risk factors that influence the incidence of postpartum iron deficiency anemia. This study is a quantitative study with a cross-sectional study design conducted at dr. Zainoel Abidin Hospital. Participants in this study were recruited using a non-probability sampling method and obtained 102 participants. Data were analyzed using chi-square tests with a confidence level of 95%. This study showed that 49.0% of the postpartum women had mild anemia, 10.8% of them had moderate anemia, and another 40.2% do not have anemia. It is found that there is a significant relationship between obstetric factors (type of labor, delivery complications) with anemia among anemia postpartum mothers ( .014 and .047 respectively).