bluuebunny/crossref_metadata_2025 huggingface dataset:
INTELLECTUAL PROPERTY AS A COMPONENT OF INTANGIBLE ASSETS OF THE ENTERPRISE
Authors: Maslak Mariya , Pererva Petro
Published: February 2023

The article proves that intellectual property management systems should interact with the economies of all countries, while the competitive advantages of intellectual property develop innovative activities in the country, create real prerequisites for its ownership. The implementation of such an approach in the field of innovation and intellectual property management should take place at all levels of management of the Ukrainian economy - from the state level to the individual enterprise. The active development of innovation, the emergence of new technologies has led to a change in policy on intellectual property and the development of practices in the management of intellectual property. Due to its importance, intellectual property becomes the basic intangible asset of enterprise management. It is substantiated that intellectual property reflects intangible assets that are legally protected and belong to a particular enterprise. This means that other companies cannot legally use them outside the company. The biggest advantage of intellectual property is that it provides an industrial enterprise with competitive advantages. It is determined that intangible assets are to some extent a complex and specific area of management, which has a strong influence on the results of production and commercial activities of industrial enterprises. A detailed analysis of the structure of intangible assets and the leading role of intellectual property in them, which is sufficiently important. The method of analysis of intangible assets of an industrial enterprise is proposed and its structural scheme is given. It is proved that intellectual property in the system of intangible assets of an industrial enterprise reproduces both positive and negative effects. The positive effect is manifested in the creation of new information that allows you to discover something new and innovative about the development of technology, nature and society. The presence of such an effect is the basis for further innovative development of scientific and technological progress in all spheres of activity. The negative effect is manifested in the existence of certain negative results or consequences of consumption of this intellectual property. It is substantiated that intellectual property, as a specific category, is still insufficiently studied by science. It still has a lot of misunderstandings, which in some cases significantly complicates the already controversial mechanism for regulating relations in the field of intellectual property. At the same time, objects and subjects of this category are already precisely defined.
FINANCIAL STIMULATION OF MANAGEMENT OF INNOVATIVE ENTREPRENEURSHIP IN THE SYSTEM OF STRATEGIC DEVELOPMENT OF ENTERPRISES IN THE INDUSTRIAL SECTOR
Authors: Nosyriev Oleksandr , Osypova Svitlana , Dedilova Tetyana
Published: February 2023

The article examines the conceptual foundations for the formation of effective management of innovative and active industrial enterprises with an emphasis on the financial component of this process. It is found out that the problem of applying effective management principles of innovative and active industrial enterprises, taking into account the financial component, is an urgent problem of our time, which requires meaningful and reasonable research. The author's own vision of the definition of the category "innovation" and "innovation activity"is presented. A management model for organizing innovation activities at an industrial enterprise has been developed. Mechanisms that should contribute to the formation of tools for effective management of innovation activities are identified. A comprehensive structure of innovative activity of an industrial enterprise is constructed. Generalizing indicators that characterize the level of innovative activity of the enterprise are identified. It is proved that the overall system of formation and development of innovatively active enterprises should be based on the following key principles, in particular: innovativeness; economic profitability; orientation to prospective consumer needs; adaptability; accounting for the life cycle of innovations; strategic efficiency; consistency; prioritization; continuity of innovative development. The main and relevant sources of financing industrial enterprise innovations for modern development are identified and the main ones are analyzed. A general conclusion is made that the financial component is a key aspect of the efficiency of functioning of innovative and active industrial enterprises in the domestic and foreign markets. Without clearly structured sources of financing for innovative projects, it is impossible to successfully implement them and obtain a fundamentally new or modified product.
Awareness of the population about primary prevention of cervical cancer
Authors:   FGBU «RNCRT named after A. M. Granov» of the Ministry of Health of Russia, Chernobrovkina A. E. , Starodubov V. I. ,   Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Belkina N. N. ,   FBU “Central Clinical Hospital of Civil Aviation”
Published: February 2023

A proven effective preventive measure against cervical cancer is a full-fledged HPV vaccination course conducted before the start of the patient’s sexual life. Its cost is essential for the realization of the possibility of using the vaccine on a voluntary basis. However, the most important argument for making a decision about vaccination is the awareness of patients about its expediency, effectiveness and safety. P u r p o s e : to identify the level of awareness of the population about the primary prevention of cervical cancer by vaccination against HPV. M a t e r i a l s a n d m e t h o d s . According to a specially developed questionnaire, an anonymous survey of adolescents and their parents (legal representatives) on the organization of HPV vaccination was conducted. The quota sample for the survey included 723 respondents who applied to women’s consultations and children’s polyclinics in St. Petersburg (a total of 19 medical organizations). R e s u l t s . In fact, only 59,7% of respondents are informed about diseases caused by HPV, and another 5,1% of those who took part in the survey are mistaken about this. Only one in three (36,4%) respondents know about the safety of currently used vaccines, and the majority of respondents – 50,8% noted that they do not know anything about this issue. Among the respondents, 87,8% indicated that given the high importance of vaccination to prevent the development of oncological diseases of the female genital area, HPV vaccinations should be carried out free of charge to citizens within the framework of the National Vaccination Calendar and the calendar of preventive vaccinations for epidemic indications. F i n d i n g s . A sociological study showed an unsatisfactory level of knowledge of the population on the issues of primary prevention of malignant neoplasms of the female genital organs.
Economic effect of vaccination as an argument in explanatory work on vaccine prevention
Authors:   Institute of Economics of the Russian Academy of Sciences, Nikolaev I. A. , Cherepov V. M. ,   State University of Management, Sobolevskaya O. V. ,   State University of Management
Published: February 2023

There is no doubt about the economic effect of vaccination. However, the relevant assessments have not yet become a convincing argument for the need for vaccination. P u r p o s e o f t h e s t u d y . Based on the results of the inventory of the existing domestic and foreign experience in determining the economic effect of vaccination, identifying management problems in the relevant explanatory work, propose other approaches on how to calculate the economic effect of vaccination and how to use this argument in explanatory work on vaccination. M a t e r i a l s a n d m e t h o d s . A comparative analytical assessment of domestic and foreign experience in the field of calculating the economic effect of vaccination has been carried out. It is analyzed what place the economic effect of vaccination has in explanatory work of state bodies on vaccination. R e s u l t s . It has been established that the insufficient effectiveness of explanatory work on vaccination is largely the result of an incorrect delineation of functions at different levels of government (municipal, regional, federal). Unreasonably large tasks in this area are assigned to the municipal level, while the federal level, on the contrary, turned out to be actually unreasonably exempted from solving the substantive tasks in the field of explanatory work on vaccine prevention. The analysis of foreign and domestic experience in determining the economic effect of vaccination confirmed the significance of the results, calculations, and estimates. The necessity of presenting the results of the assessment of the economic effect of vaccination in a simpler and more understandable form is substantiated. For this purpose, an assessment was made of what can give the economy in value terms 25 years of additional human life, which he received in the 20th century thanks, according to experts, to vaccination. The calculation of GDP per capita (according to Rosstat for 2021, in purchasing power parity) for 25 years of extra human life due to vaccination was carried out. The need to consider the issue of the advisability of paying people for vaccination is substantiated. F i n d i n g s . It is necessary to reconsider the traditional approaches to assessing the economic effect of vaccination. State and municipal authorities should update the tasks in the field of vaccination in order to increase its effectiveness.
Clivelend clinic case study on pateint experience inprovement and workplace empathy development
Authors:   International Medical Cluster Foundation, Rakhmatullin R. E. , Altyeva A. A. ,   International Medical Cluster Foundation
Published: February 2023

The article presents a case-study of the patient experience improvement strategy and empathy development among healthcare professionals in Cleveland Clinic, USA. Key activities of the Patient Experience Department and the main components of the corporate program for empathy development “Communicate with H.E.A.R.T.” are also described, as well as the effectiveness of these programs.
AOA Critical Issues Symposium: Mind the Gap
Authors: Samora Julie B. , Ghanayem Alexander J. , Lewis Valerae O. , Weber Kristy
Published: February 2023

Orthopaedic surgeons in training and in their careers can experience a lack of confidence and imposter syndrome. Confidence is built early through continuous improvement, accomplishments, support, and reinforcement. Although it is normal to lack confidence at times, the goal is to recognize this issue, work on visualizing success, and know when to seek help. Mentors can help mentees to build confidence and to normalize thoughts of insecurity and imposter syndrome. It is critical to develop and to maintain resilience, grit, emotional intelligence, courage, and vulnerability during training and throughout one’s entire orthopaedic career. Leaders in the field must be aware of these phenomena, be able to talk about such issues, have methods to combat the harmful effects of imposter syndrome, and create a safe, supportive environment conducive to learning and working. Leading well builds not only confidence in oneself but also self-confidence in others. Leaders who are able to build the confidence of individuals will enhance team dynamics, wellness, and overall productivity as well as individual and organizational success.
Soybean Germplasms Performance to Soil Salinity
Authors: Taufiq Abdullah , Nugrahaeni Novita , Subekti Nuning Agro , Sembiring Hasil
Published: February 2023

Saline soil is a prospective land for expanding the soybean planting area in Indonesia, but no variety with the ability to adapt to this soil has currently been released. That objective of this esearch was to identify the salt-tolerant soybean germplasm accessions. The experiment consisted of two treatments and these were arranged in a randomized complete block design with three replications. The first factor was three soil salinity levels i.e. 1.44-1.72 dS/m (used as a check), 6.75±0.40 dS/m, and 10.48±0.30 dS/m. The second factor was 25 soybean accessions selected from previous salinity screening activity. Parameters observed were soil electrical conductivity (EC), plant height, yield and yield attributes, as well as K, Ca, and Na concentration in soil and plant. The results showed that salinity treatment increased the soil EC, Na concentrations in shoot and root, and reduced K, thereby causing a reduction in soybean growth, seed weight, and seed size. Meanwhile, MLGG 0169, MLGG 0640, MLGG 0767 (Lokon variety), MLGG 1109 (Dega 1 variety), and MLGG 1098 (Detam 2 variety) were identified as tolerant tosalinity level up to 10.48±0.30 dS/m.  The tolerant genotypes were characterized by high ITC index, high seed yield, fewer reduction of seed yield, and mild leaf damage. The tolerances were likely determined by the ability to absorb more K and less Na, translocate more K from root to shoot, and higher K/Na ratio in shoot and root than Ca/Na ratio. It means the K/Na ratio is more important in determining salinity tolerance than Ca/Na ratio. Therefore, accessions can be used as gene source for salt-tolerant breeding, and Lokon, Dega 1, and Detam 2 varieties were recommended for saline soil.
Performance of Agronomic Characters of Soybean Lines Derived from Different Crossing
Authors: Purwantoro Purwantoro , Sutrisno Sutrisno , Kuswantoro Heru
Published: February 2023

High productivity has always been a top priority in current soybean plant breeding activities. The availability of high yielding varieties would considerably increase the national soybean production and have a positive impact on farmers’ income and welfare. This study aimed to evaluate selected soybean characters supporting high yield in several genotype crosses. The study was conducted in 2017 using 26 soybean lines derived from crosses among different parents. A randomized block design was used with three replications. The results showed that the soybean lines tested showed differences in days to flowering, days to maturity, plant height, number of branches per plant, number of productive nodes per plant, number of filled pods per plant, 100-seed weight, and seed yield per plot. The lines with the same days to maturity were related to selection process. Seed yield was significantly correlated with the number of productive nodes per plant, and the number of filled pods per plant. The parent of the cross had an effect on the grouping. There were two major groups with Tgm/Anj-773 as a separate group. The highest number of filled pod was achieved by Grb/Lwt-17, while the highest seed yield was noted in Tgm/Anj-773. In addition to the highest seed yield, Tgm/Anj-773 also had early days to flowering, as well as many number of branches, productive nodes and filled pods, thus this genotype is promising to be released as a variety with high yield potential.
CURRENCY CRISES AND CONTAGION CHANNELS IN ASIAN ECONOMIES
Authors: Kyin Tey Sheik , Chin Lee
Published: February 2023

This study examines multiple transmission mechanisms that propagate and amplify shocks across Asian nations owing to financial turbulence with emphasis on global shock transmission between economies that prioritise ‘trade’ and ‘financial’ connections in four countries: Indonesia, Korea, Malaysia, and the Philippines. Based on the logit estimation outcomes, a higher degree of trade openness amplifies the implications of shocks on the economy. Relevant implications are drawn for optimal regional monitoring and the coordination of integration as the economic fundamentals associated with the currency crises complements the first-generation models of speculative attacks.
Música popular y archivo sonoro
Authors: De la Fuente Soler Manuel
Published: February 2023

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El archivo musical del siglo XX
Authors: Carballar Diego , Español Español
Published: February 2023

El artículo examina una experiencia pedagógica que se transformó en una indagación teórica y de metodologías analíticas. Si bien el punto de partida fueron textos expuestos en una serie arbitraria (la de la letra B), bien pronto se extendió ese principio (esa restricción) al corpus musical del siglo XX. La propuesta de trabajo, que llamamos «Bien de archivo», quería encontrar en un acotado espacio de experimentación las líneas fundamentales del arte (y de la política estética) del siglo XX.
Generación pirata. El rock como un espacio de disidencia desde una Nicaragua en transición.
Authors: Barinova Martina
Published: February 2023

La investigación presente traza la historia del rock nicaragüense, desde las raíces que se conectan a la construcción de la noción de la cultura nacional en la década de 1930, hasta la actualidad. Se contextualiza el papel de la música popular en diferentes momentos de la historia reciente del país, para mostrar la importancia de la radio al difundir y popularizar ciertos géneros musicales tanto como mensajes políticos. A base de entrevistas personales y análisis de videodocumentales se exploran las tendencias políticas en la escena cultural alternativa, y particularmente en la comunidad rockera, a partir de 1990. Entendemos la década de 1990 como un momento de ruptura generacional, cuando el rock se convierte en un movimiento antisistema, en una plataforma de expresión disidente que, al mismo tiempo, muestra cierta continuidad con el pensamiento izquierdista de los predecesores musicales locales.
Rock ’n’ roll, nueva ola y rock de garaje: una explicación estética del surgimiento de la música rock en el Perú
Authors: Melgar Wong Francisco
Published: February 2023

En sus textos más difundidos, los historiadores del rock peruano promueven ambigüedades semánticas en torno a los términos rock, nueva ola y rock ’n’ roll, y dejan abierto un vacío explicativo en relación con la aparición de la música rock en el Perú. Este artículo busca aclarar estas ambigüedades y ofrecer una explicación al surgimiento del rock en el Perú. Para ello, el autor propone una aproximación estética basada en las funciones sociales que músicos y oyentes le asignan a un conjunto de parámetros musicales en un determinado contexto histórico. Por último, el artículo aclara el significado de los términos que designan a los géneros musicales ya mencionados y demuestra que el surgimiento del rock en el Perú involucró la continuidad de algunas características de los géneros que lo precedieron, así como innovaciones lo suficientemente importantes como para designar la aparición de un nuevo género musical en este país.
Cumbia fusión: desarrollo e impacto de una escena musical «alternativa» en Lima
Authors: Olazo Jorge
Published: February 2023

El artículo analiza cómo el crecimiento de la escena de cumbia fusión ha sido un factor determinante para la programación de orquestas de cumbia tradicional en festivales masivos considerados rockeros o «alternativos» en la ciudad de Lima. Es un estudio exploratorio que conecta con las aproximaciones teóricas de Small (1998), Gell (1998), y particularmente con Straw (1991) y Bennett (2004). Como metodología se utiliza entrevistas en profundidad a protagonistas de la escena de cumbia fusión, conducidas entre febrero de 2019 y agosto de 2020. Para la discusión se toma como estudio de caso la trayectoria de dos agrupaciones representativas: Olaya Sound System y La Nueva Invasión. Se demuestra que los mecanismos de autogestión implementados por las bandas de cumbia fusión sirvieron para que su ejercicio artístico resulte viable económicamente, y, en ese proceso, comiencen a aplicar estrategias de producción musical y de gestión comercial para tentar un público más amplio.
Resiliencia y reconstrucción: lecturas sobre vulnerabilidad y el impacto de violencia de género (2019-2021)
Authors: Perusset Macarena
Published: February 2023

Este trabajo reconstruye el camino seguido por Flavia, una mujer víctima de violencia de género, que junto con sus dos hijas dejó su casa en la provincia de La Rioja y se dirigió hacia una pequeña comuna del noroeste cordobés, Argentina. Nos basamos en el trabajo etnográfico realizado, que analizó la búsqueda y construcción de un hogar, para lo que abordamos el concepto de vulnerabilidad. El trabajo de campo nos permite explorar cómo las mujeres y sus familias que han atravesado situaciones de violencia de género viven en «hogares vulnerables» y pudieron reconstruirse frente a los eventos de violencia apoyándose en los lazos familiares y en redes sociales de apoyo para volver a formar un hogar. Este trabajo nos permite, además, observar la manera en que el término vulnerabilidad fue utilizado en distintas situaciones o escenarios como recurso moral y burocrático, tanto por las autoridades públicas, para seleccionar a quienes proteger, como por las personas vulneradas, para reclamar sus derechos. La vulnerabilidad emerge como un espacio de experiencia en el que las personas aprenden a navegar y en el que se superponen la angustia, la creatividad y las redes de apoyo social.
Diario de Santa María, una novela heterogénea
Authors: Vargas Bautista Abraham
Published: February 2023

El presente artículo analiza la novela Diario de Santa María de Edgardo Rivera Martínez. La crítica ha convenido en resaltar el mestizaje armónico como el gran aporte de su obra. Este concepto refiere la representación de una relación horizontal de las culturas andina y occidental. Entonces, la novela estaría proponiendo una sociedad sin conflictos sociales, donde las sociedades retratadas logran convivir pacífica y simétricamente. El análisis propuesto en este artículo es una crítica a la idea del mestizaje armónico. Nuestra lectura se sustenta en la categoría de heterogeneidad de Cornejo Polar. Este concepto nos ha permitido tener una mirada crítica sobre el mestizaje armónico en Diario de Santa María. Concluimos que si bien el racismo y el clasismo no gobiernan las relaciones interpersonales entre los personajes, sí subyace a la obra un pensamiento colonial, donde la cultura europea goza de mayor prestigio en el imaginario de la protagonista.
“Dog boy, media whore. It’s who the hell you take me for”
Authors: Vannieuwenhuyze Tessa
Published: February 2023

This article investigates how the persona enacted at the end of the 1990s by Brian Molko - British band Placebo’s lead singer and guitarist  - resonates with contemporary approaches of persona performance. Amplified by presentational media along the lines of Instagram, YouTube, and Twitter, persona increasingly proliferates as enmeshed in everyday practices and identities. This is no different in the domain of (popular) music. Yet, contemporary music personas whose image approximates ordinariness rather than extravaganza do sometimes reject the connotation of artificiality attached to the term persona, resulting in a type of ‘reluctant persona’.
Practicing a form of anecdotal theory (Gallop 2002), I tap into how I experienced Molko’s persona through fan archives, and link his historical negotiation of an ‘ordinary extraordinariness’ with this present-day reluctant persona. A close re-reading of a selection of 1997-1999 music magazine articles in the Placebo Russia archive not only shows how Molko’s music magazine persona curates identity markers of extraordinariness as ordinary, but also demonstrates how the media texts that go into a persona continually perform these anew. Through the lens of performance studies, online fan archives shed light on the intensified correlation between (new) media and music artists’ engagement with performing the ordinary, subsequently entangling the discourses of theatricality and performativity.
De novo identification of complex traits associated with asthma
Authors: Zaied Roan , Fadason Tayaza , O'Sullivan Justin
Published: February 2023

Network analysis is a powerful approach for untangling the relationships between complex diseases. Here, we integrated information on physical contacts between common single nucleotide polymorphisms (SNPs) and gene expression with expression quantitative trait loci (eQTL) data from the lung and whole blood to construct two tissue-specific spatial gene regulatory networks (GRN). From these GRNs, we located the genes that are functionally affected by asthma-associated eQTLs to identify the asthma GRN. We then expanded outwards to identify curated protein-protein interactions occurring 1 to 4 edges away from the asthma GRN. The eQTLs spatially regulating the identified genes were used to interrogate the GWAS Catalog to identify enriched traits (hypergeometric test; FDR≤0.05) within the asthma GRN and each of the 4 levels. This led to the de novo identification of traits both previously reported (e.g., depressive symptoms and lung cancer) and unreported (e.g., reticulocyte count) to be comorbid or associated with asthma. It additionally pinpoints the variants and genes that link asthma to the identified asthma-associated traits, a subset of which was replicated in a comorbidity analysis using health records of 26,781 asthma patients in New Zealand. Our discovery approach identifies enriched traits in the regulatory space proximal to asthma, in the tissue of interest, without a priori selection of the interacting traits. The predictions it makes expand our understanding of possible shared molecular interactions and therapeutic targets for asthma, where no cure is currently available.
A Deep Learning Solution for Real-time Quality Assessment and Control in Additive Manufacturing Using Point Cloud Data
Authors: Akhavan Javid , Lyu Jiaqi , Manoochehri Souran
Published: February 2023

This work presents an in-situ quality assessment and improvement technique using point cloud and AI for data processing and smart decision making in Additive Manufacturing (AM) fabrication to improve the quality and accuracy of fabricated artifacts. The top surface point cloud containing top surface geometry and quality information is pre-processed and passed to an improved deep Hybrid Convolutional Auto-Encoder decoder (HCAE) model used to statistically describe the artifact's quality. The HCAE’s output is comprised of 9*9 segments, each including four channels with the segment's probability to contain one of four labels, Under-printed, Normally-printed, Over-printed, or Empty region. This data structure plays a significant role in command generation for fabrication process optimization. The HCAE’s accuracy and repeatability were measured by a multi-label multi-output metric developed in this study. The HCAE’s results are used to perform a real-time process adjustment by manipulating the future layer's fabrication through the G-code modification. By adjusting the machine's print speed and feed-rate, the controller exploits the subsequent layer’s deposition, grid-by-grid. The algorithm is then tested with two defective process plans: severe under-extrusion and over-extrusion conditions. Both test artifacts' quality advanced significantly and converged to an acceptable state by four iterations.
Ibrutinib versus bendamustine plus rituximab for first-line treatment of older patients with untreated chronic lymphocytic leukemia without del(17p)/TP53 mutation in China: A lifetime economic research study
Authors: Hong Yuan , Chen Xichuang , You Xiaohong , Wang Yan , Hong Yuanquan , Mi Jingyi , Xiao Xingfang , Zhou Tao , Zheng Panpan , Huang Zhihu
Published: February 2023

Background
The incidence and mortality rates of patients with chronic lymphocytic leukemia (CLL) in China have recently increased. This study performed a long-term economic evaluation of the first-line treatment strategies ibrutinib (IB) or bendamustine (BE) plus rituximab (RI) for previously untreated older patients with CLL without the del(17p)/TP53 mutation in China.
Methods
Based on clinical data from large, randomized trials, a Markov model including four disease states (event-free survival, treatment failure, post-treatment failure, and death) was used to estimate the incremental costs per quality adjusted-life year (QALY) gained from the first-line IB strategy versus the BE plus RI strategy over a 10-year period. All costs were adjusted to 2021 values based on the Chinese Consumer Price Index, and all costs and health outcomes were discounted at an annual rate of 5%. Sensitivity analysis was performed to confirm the robustness of base-case results.
Results
Compared to the first-line BE plus RI strategy, first-line IB treatment achieved 1.17 additional QALYs, but was accompanied by $90,843.67 (estimated in 2021 US dollars) in decremental costs per patient over 10 years. Thus, first-line treatment with IB appeared to have absolute dominance compared to the BE plus RI strategy. Sensitivity analysis confirmed the robustness of these results.
Conclusions
From the perspective of the Chinese health care system, first-line treatment with IB is absolutely cost-effective compared to the first-line BE plus RI strategy for the treatment of older patients with CLL without the del (17p)/TP53 mutation. Therefore, we strongly recommend that Chinese health authorities select the former strategy for these CLL patients.
NudCL2 is essential for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody
Authors: Xu Xiaoyang , Huang Yuliang , Yang Feng , Sun Xiaoxia , Lin Rijin , Feng Jiaxing , Yang Mingyang , Shao Jiaqi , Zhou Tianhua , Yang Yuehong
Published: February 2023

Cytokinesis is required for faithful division of cytoplasmic components and duplicated nuclei into two daughter cells. However, its underlying mechanism remains elusive. Here, we show that an Hsp90 co-chaperone NudC-like protein 2 (NudCL2) regulates cytokinesis by stabilizing regulator of chromosome condensation 2 (RCC2) in mammalian cells. NudCL2 co-localizes with RCC2 at the midbody and is required for RCC2 stabilization. Either NudCL2 knockout (KO) or RCC2 depletion causes similar phenotypes, including cytokinesis failure, midbody disorganization, and multinucleation. Ectopic expression of RCC2 effectively reverses the cytokinesis defect induced by NudCL2 KO. Furthermore, Hsp90 is also found to co-localize with NudCL2 at the midbody and is involved in NudCL2-mediated RCC2 stability and cytokinesis. Interestingly, our results reveal that the mRNA and newly synthesized peptides of RCC2 accumulate at the midbody. Loss of NudCL2 decreases the nascent RCC2, but not RCC2 mRNA, at the midbody. Taken together, our data provide a previously undescribed mechanism showing that NudCL2/Hsp90/RCC2 pathway is essential for cytokinesis at the midbody.
How does personalized feedback on carbon emissions impact intended climate action?
Authors: Luo Yu , Hanson-Wright Brynley , Dowlatabadi Hadi , Zhao Jiaying
Published: February 2023

Carbon emissions associated with individual choices are difficult to conceptualize and seldom considered in daily decision making. We examine the impact of personalized feedback on carbon emissions on intended climate action. In a pre-registered experiment (N=790), participants reported their consumption in 2019 and received personalized feedback on carbon emissions and recommendations for reduction in the feedback condition, or no feedback in the control condition. Subsequently, all participants indicated their consumption intentions in 2023, which was one year from the year the experiment was conducted. After receiving feedback, participants showed a significant emission reduction of 1.42tCO2e (-12.60%) per capita between 2019 and 2023, whereas those in the control condition increased their emissions by 0.05tCO2e (+0.045%). Importantly, there was no impact on intentions to engage in civic climate action. Civic climate intentions were instead associated with eco-guilt and climate concerns. These findings suggest personalized feedback has the potential to reduce carbon emissions without impacting civic climate intentions, providing implications for strategies to encourage climate action.
Deep transfer learning radiomics based on two-dimensional ultrasound for predicting the efficacy of neoadjuvant chemotherapy in breast cancer
Authors: Wang Zhan , Zhao Tong , Zhang Heng , Zhang Chao , Duan Tongtong , Li Xiaoqin , Xu Lingyun
Published: February 2023

Purpose
We investigate the predictive value of a comprehensive model based on preoperative ultrasound radiomics, deep migration learning, and clinical features for pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for the breast cancer.
Methods
We enrolled 211 patients with pathologically confirmed the breast cancer who underwent NAC. The patients were randomly divided into the training set and the validation set in the ratio of 7:3. The deep learning and radiomics features of pre-treatment ultrasound images were extracted, and the random forest recursive elimination algorithm and the least absolute shrinkage and selection operator were used for feature screening and DL-Score and Rad-Score construction. According to multiple logistic regression, independent clinical predictors, DL-Score, and Rad-Score were selected to construct the comprehensive prediction model DLR + C. The performance of the model was evaluated in terms of its predictive effect, calibration ability, and clinical practicability.
Result
Compared to the clinical, radiomics (Rad-Score), and deep learning (DL-Score) models, the DLR + C accurately predicted the pCR status, with an area under the curve (AUC)of 0.906 (95% CI: 0.871–0.935) in the training set and 0.849 (95% CI: 0.799–0.887) in the validation set, with good calibration ability (Hosmer-Lemeshow: P > 0.05). Moreover, decision curve analysis confirmed that the DLR + C had the highest clinical value among all models.
Conclusion
The comprehensive model DLR + C based on ultrasound radiomics, deep transfer learning, and clinical features can effectively and accurately predict the pCR status of breast cancer after NAC, which is conducive to assisting clinical personalized diagnosis and treatment plan.
Comparative seasonal analysis of Eri silkworm (Samia ricini Donovan) gut composition: implications for lignocellulose degradation
Authors: Gogoi Parishmita , HatiBaruah Jyoti L , Yadav Archana , Debnath Rajal , Saikia Ratul
Published: February 2023

Conversion of biomass such as lignocelluloses to alternative energy source can contribute to sustainable development. Recently, biomass degrading enzymes are reported to be common resources in insect-microbe interacting systems. North-East India harbours ample sericigenous insect resources which are exploited for their silk products. Samia ricini Donovan is an economically important poly-phytophagous silkmoth capable of digesting foliage from different plant species, suggesting versatility of robust gut system. Here, gut bacterial profile was determined by 16S rRNA gene characterization across the holometabolous life cycle during summer and winter seasons revealing 3 phyla, 13 families and 22 genera. Comparative analysis among the seasonal gut isolates revealed a high diversity in summer, predominated by genus Bacillus due to its high occurrence in all developmental stages. Shannon’s diversity index demonstrated second and fourth instars of summer as well as fifth instar of winter to be relatively better developmental stages for gut bacteria assemblance. Bacterial community shifts in concert to host developmental changes were found to be apparent between early instars and late instars in summer which differs from those of winter. Forty-three and twenty-nine gut isolates were found to be a potential cellulolytic and xylanolytic enzyme producers. Our results illustrates gut microbiota of S .ricini over the seasons and support holometabolous life cycle effect as the more likely factor shaping gut bacterial microbiota. These findings may provide leads for development of new cleaner and environment friendly lignocelluloses degrading enzymes.
Perceptions of people living with human immunodeficiency virus regarding the use of dolutegravir based regimen, Limpopo Province
Authors: Sibeko Zandile Rachel , Molato Boitumelo Joy , Moloko-Phiri Salaminah
Published: February 2023

Background
HIV and AIDS continue to be a public health concern with Sub-Saharan Africa having the highest number of HIV incidences. Progress towards management of the disease has been implemented over the years and antiretroviral therapy has been a great achievement. The World Health Organisation recommended dolutegravir as the second line of treatment for the disease. Literature explains DTG based regimen as having great outcomes although it was discovered to have unpleasant side effects on some patients. The objective was to explore and describe perceptions of PLWHA regarding the use of dolutegravir based regimen in Limpopo province.
Method
A qualitative, explorative-descriptive design was followed. Individual semi-structured in-depth interviews were conducted. Purposive sampling was used until data saturation was reached. Thematic analysis was used, and the following themes generated: Acceptance of dolutegravir, level of knowledge regarding dolutegravir, the burden of knowledge regarding dolutegravir, the burden of taking ART treatment, the reasons for non-adherence to dolutegravir.
Results
The findings revealed great acceptance of DTG. The importance of taking treatment was mentioned although some participants lacked knowledge.
UV filters in everyday cosmetic products, a comparative study
Authors: Couteau Céline , Philippe Anne , Galharret Jean-Michel , Metay Emilie , Coiffard Laurence
Published: February 2023

Today, UV filters are found as contaminants in a variety of biological fluids and environment, e.g. in vegetable crops and surface water. This is because UV filters are widely used in everyday products. In this context, we focused this study on cosmetic products. The study of 742 cosmetic products, excluding actual sunscreen products, but including hygiene, personal care and make-up products and perfumes revealed that the most common UV filters present are butyl methoxydibenzoylmethane, octyl methoxycinnamate, octocrylene, octyl salicylate and titanium dioxide. Few UV filters are found in the hygiene products and deodorants and toothpastes are completely free of them. Conversely, make-up and perfumes are frequently formulated with at least one UV filter.
Phenomenological Description of the acidityof the Citric Acid and its DeprotonatedSpecies: Informational-Theoretical Study
Authors: Vazquez-Hernandez Hazel , Esqu Rodolfo O
Published: February 2023

Context
In spite of the fact that molecular acidity is a fundamental physicochemical property of molecular systems, the vast majority of theoreticalstudies have focused attention on monoprotic acids and on the prediction of pKa’s. Polyprotic acids, represent a challenge for electronicstructure calculations since the multiple acidic sites result in a vastgroup of species with different conformations and reactivities. In thiswork, Information-theoretic (IT) concepts of localizability, order anduniformity are applied to the Citric Acid and its deprotonated speciesthrough the one-electron density functionals: Shannon entropy (S),Fisher information (I) and disequilibrium (D), respectively. We pursuethe goal of characterizing the acidity of the aforementioned species withthe aim to associate the IT concepts to chemical features such as thepolarizability of the protonated/deprotonated species, the liability ofthe acidic sites, atomic electrostatic potentials, covalent bonding. ITanalyses looks very promising for future studies on the acidity of specificdeprotonation-sites of polyprotic acids.
Methods
Density functional theory (DFT) calculations were performed with Gaussian 09 program. A sensitivity analysis of the IT-measures was performed for the citric acid and the citrate using B3LYP, B3PW91, BPW91, M05-2X, M06-2X and PBEPBE functionals with the 6-311++g(3df,2p), 6-311++g(d,p), 6.311+g(d,p) and aug-cc-pVDZ basis sets. The rest of the analysis was performed with the M05-2X/6-311+G(d,p) level of theory. Additionally, aqueous media was considered by use of the SMD solvent model. The IT-measures were calculated using a suite of programs developed in our laboratory jointly with the DGRID software package.
Structural Modulation of Low-Cost Cu-Mn-Fe Prussian Blue Analogs for Long-Calendar-Life Sodium Ion Batteries
Authors: Gao Yun , Zhang Hang , Wang Jinsong , Peng Jian , Xiao Yao , Liu Yang , Yun Qiao , Li Li , Wang Jia-zhao , Chou Shulei
Published: February 2023

High electrochemical-performance and cost-efficient cathodes are crucial for the development of grid-scale sodium-ion batteries (SIBs). Prussian blue analogs (PBAs) are generally regarded as promising cathode candidates for SIBs, although their practical application has been limited by low capacity or poor cycling ability caused by their poor crystallinity and reversibility. Herein, a series of low-cost and high-quality ternary PBAs are prepared by structural regulation to simultaneously achieve high capacity, stable cyclability, and wide temperature suitability. The prepared CuHCF-3 sample has delivered a high specific capacity of 132.4 mAh g-1 with 73.3% capacity retention over 1000 cycles when applied as a cathode material for SIBs. A highly reversible three phase (monoclinic to cubic to tetragonal) sodium-ion storage mechanism is revealed via multiple in-situ techniques. Density functional theory calculations indicate that the key for achieving high capacity and long lifespan lies in the synergistic effect of Mn and Cu in the crystal structure of PBAs. The presence of Mn could enhance electronic conductivity, improve the operating voltage, and provide more possible redox centers while the presence of Cu-ions can restrain the Jahn-Teller distortions and buffer huge volume expansion during cycling. Furthermore, the wide-temperature suitability of these materials and Na-ion full cells are investigated based on kilogram-scale production as a demonstration for their practical application. We hope that this work can provide new insights into designing high-performance and low-cost electrode materials for practical grid-scale energy storage systems.
A Joint Optimization Scheme of Task Caching and Offloading for Smart Factories
Authors: Qu Xiaofeng , Wang Huiqiang
Published: February 2023

In the application scenario of the smart factory, the computing tasks of smart devices are intensive and the tasks are sensitive to delay. The smart device needs to offload the task to the edge server for execution. However, the computing resources of edge servers are limited and there will be workload imbalance among multiple edge servers. To solve these problems, we propose a joint optimization scheme of task caching and offloading based on task scene awareness, which decouples the joint optimization problem of task caching and offloading into two subproblems: task caching and task offloading. For the task caching subproblem, a bilateral auction task caching algorithm based on task scene awareness is proposed. For the task offloading subproblem, a task offloading algorithm based on task scenario offloading preferences is proposed. The experimental results show that the optimization scheme proposed in this paper has obvious performance advantages when the number of tasks is large and the number of intelligent devices is large. This scheme also achieves workload balancing among multiple edge servers.
Anti-ganglioside antibody positive neuromyelitis optica spectrum disease with peripheral neuropathy: a case report
Authors: Li Yangchun , Tang Man , Yu Lu , He Ying , Liang Lisong , Qu Hao , Si Wei , Hu Xiao
Published: February 2023

Background
Neuromyelitis optica spectrum disease (NMOSD) is a demyelinating disease of the central nervous system primarily involving the optic nerve and spinal cord. There are limited reports of NMOSD associated with peripheral nerve damage.
Case presentation
We report a 57-year-old female patient who met the diagnostic criteria for aquaporin-4 (AQP4) IgG-positive NMOSD with undifferentiated connective tissue disease andmultiple peripheral neuropathy. In addition, the patient was positiveformultiple anti-ganglioside antibodies (anti-GD1a IgG antibodies and anti-GD3 IgM antibodies) and anti-sulfatide IgG antibodies in serum and cerebrospinal fluid. After treatment with methylprednisolone, gamma globulin, plasma exchange, and rituximab, the patient’s status improved and was subsequently discharged from our hospital.
Conclusions
The neurologist should be aware of the unusual association between NMOSD and immune-mediated peripheral neuropathy. Undifferentiated connective tissue disease and nerve damage mediated by multiple antibodies may have combined to cause peripheral nerve damage in this patient.
Pathological biomarkers predict recurrence and metastasis in patients with lacrimal gland adenoid cystic carcinoma
Authors: Zhou Xiaowen , Feng Yiyi , Yang Yidi , Li Shuai , Zong Chunyan , Yu Yilin , Zhu Tianyu , Shi Jiahao , Jia Renbing , Fan Xianqun , Chen Huifang , Li Yimin , Song Xin
Published: February 2023

Background
Lacrimal gland adenoid cystic carcinoma is the most common lacrimal gland malignant epithelial tumour, characterized by high rates of relapse and distant spread. As few studies have reported pathological biomarkers for LGACC, we aimed to identify biomarkers that can predict the recurrence and metastasis of LGACC.
Methods
Twenty-eight patients diagnosed with LGACC between 2008 and 2022 were included. The level of expression of ASCT2, GLS1, MCT4, and SHMT1 in patients with LGACC was evaluated by immunohistochemistry and the concordance was calculated. Patients were divided into negative and positive groups according to the staining results of ASCT2, and high or low expression groups according to the staining scores of GLS1, MCT4, and SHMT1. The recurrence-free survival, metastasis-free survival, and overall survival were analysed and compared between groups.
Results
The study participants comprised 16 males and 12 females, with a median age of 52.4 years (range: 30–77 years). During a 34.3-month median follow-up (range: 0.4–125.1 months), 7 (25%) patients suffered recurrence, 8 (28.6%) patients had metastasis, and 4 (14.3%) patients died due to LGACC. Patients with negative ASCT2 expression had a significantly shorter recurrence-free survival (p = 0.007), metastasis-free survival (p = 0.033), and poorer overall survival (p = 0.028). Multivariate analysis showed that ASCT2 was an independent risk factor for disease recurrence (HR = 0.1, 95% CI: 0.012–0.88, p = 0.038).
Conclusions
ASCT2 negative expression is a predictor to identify patients with poor recurrence-free survival, metastasis-free survival, and overall survival.