bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Air Abrasion on the Number of Particles Embedded in Zironia
Authors: Śmielak Beata , Klimek Leszek
Published: February 2018

Background: Determination of the number of abrasive particles embedded in the zirconia surface after variable parameters of treatment. Methods: One hundred thirty cylindrical disks made from zirconia were divided into 7 groups (n = 10): one control and six test groups treated by air abrasion using Al2O3 or SiC with grain sizes: 60, 110, 250 μm with a working pressure of 0.2 or 0.35 MPa. The SEM images were observed in BSE and BSE 3D. The chemical composition was determined by means of X-ray microanalysis with EDS. The surface was determined by quantitative metallography methods. Surfaces (%) depending on the particle type were compared using the Mann-Whitney test, depending on the pressure were compared using the Mann-Whitney test, and depending on the grain size were compared using the Kruskal-Wallis test as well as the Jonckheere-Terpstra trend test as well as the Dunn post-hoc testA probability. Value of p < 0.05 was deemed significant, while a p-value of p < 0.01 was regarded as highly significant. Results: After blasting aluminium and silicon particles were embedded in zirconia surface. When blasted with Al2O3, the average amount of embedded grain was higher, while in the case of SiC. Highly significant differences were observed in the surface share of the abrasive depending on the grain size. At a pressure of 0.20 MPa the quantity of embedded abrasive amounted to 6.63, and at the pressure of 0.35 MPa rose to 7.17. Most particles of abrasive material became embedded when sandblasting with grain size 60 μm grain. No significant difference was observed in the surface share of the abrasive depending on the pressure. Conclusion: The quantity of embedded abrasive depends on its type and grain size, and the pressure applied.
Composite Laser Ceramics by Advanced Bonding Technology
Authors: Ikesue Akio , Aung Yan , Kamimura Tomosumi , Honda Sawao , Iwamoto Yuji
Published: February 2018

Composites obtained by bonding materials with the same crystal structure and different chemical compositions can create new functions that do not exist in conventional concepts. We have succeeded in bonding polycrystalline YAG and Nd:YAG ceramics without any interstices at the bonding interface, and the bonding state of this composite was at the atomic level, similar to the grain boundary structure in ceramics. The mechanical strength of the bonded composite reached 278 MPa, which was not less than the strength of each host material (269 and 255 MPa). Thermal conductivity of the composite was 12.3 W/mK (theoretical value) which is intermediate between the thermal conductivities of YAG and Nd:YAG (14.1 and 10.2 W/mK, respectively). Light scattering cannot be detected at the bonding interface of the ceramic composite by laser tomography. Since the scattering coefficients of the monolithic material and the composite material formed by bonding up to 15 layers of the same materials were both 0.10%/cm, there was no occurrence of light scattering due to the bonding. In addition, it was not detected that the optical distortion and non-uniformity of the refractive index variation were caused by the bonding. An excitation light source (LD = 808 nm) was collimated to 200 μm and irradiated into a commercial 1% Nd:YAG single crystal, but fracture damage occurred at a low damage threshold of 80 kW/cm2. On the other hand, the same test was conducted on the bonded interface of 1% Nd:YAG-YAG composite ceramics fabricated in this study, but it was not damaged until the excitation density reached 127 kW/cm2. 0.6% Nd:YAG-YAG composite ceramics showed high damage resistance (up to 223 kW/cm2). It was concluded that composites formed by bonding polycrystalline ceramics are ideal in terms of thermo-mechanical and optical properties.
Nanostructure and Corresponding Quenching Efficiency of Fluorescent DNA Probes
Authors: Guo Wenjuan , Wei Yanhong , Dai Zhao , Chen Guangping , Chu Yuanyuan , Zhao Yifei
Published: February 2018

Based on the fluorescence resonance energy transfer (FRET) mechanism, fluorescent DNA probes were prepared with a novel DNA hairpin template method, with SiO2 coated CdTe (CdTe/SiO2) core/shell nanoparticles used as the fluorescence energy donors and gold (Au) nanoparticles (AuNPs) as the energy acceptors. The nanostructure and energy donor/acceptor ratio in a probe were controlled with this method. The relationship between the nanostructure of the probes and FRET efficiency (quenching efficiency) were investigated. The results indicated that when the donor/acceptor ratios were 2:1, 1:1, and 1:2; the corresponding FRET efficiencies were about 33.6%, 57.5%, and 74.2%, respectively. The detection results indicated that the fluorescent recovery efficiency of the detecting system was linear when the concentration of the target DNA was about 0.0446–2.230 nmol/L. Moreover, the probes showed good sensitivity and stability in different buffer conditions with a low detection limit of about 0.106 nmol/L.
Elucidating Grinding Mechanism by Theoretical and Experimental Investigations
Authors: Ullah AMM Sharif , Caggiano Alessandra , Kubo Akihiko , Chowdhury M. A. K.
Published: February 2018

Grinding is one of the essential manufacturing processes for producing brittle or hard materials-based precision parts (e.g., optical lenses). In grinding, a grinding wheel removes the desired amount of material by passing the same area on the workpiece surface multiple times. How the topography of a workpiece surface evolves with these passes is thus an important research issue, which has not yet been addressed elaborately. The present paper tackles this issue from both the theoretical and the experimental points of view. In particular, this paper presents the results of experimental and theoretical investigations on the multi-pass surface grinding operations where the workpiece surface is made of glass and the grinding wheel consists of cBN abrasive grains. Both investigations confirm that a great deal of stochasticity is involved in the grinding mechanism, and the complexity of the workpiece surface gradually increases along with the number of passes.
Seaweed Bioactive Compounds against Pathogens and Microalgae: Potential Uses on Pharmacology and Harmful Algae Bloom Control
Authors: Zerrifi Soukaina , El Khalloufi Fatima , Oudra Brahim , Vasconcelos Vitor
Published: February 2018

Cyanobacteria are found globally due to their adaptation to various environments. The occurrence of cyanobacterial blooms is not a new phenomenon. The bloom-forming and toxin-producing species have been a persistent nuisance all over the world over the last decades. Evidence suggests that this trend might be attributed to a complex interplay of direct and indirect anthropogenic influences. To control cyanobacterial blooms, various strategies, including physical, chemical, and biological methods have been proposed. Nevertheless, the use of those strategies is usually not effective. The isolation of natural compounds from many aquatic and terrestrial plants and seaweeds has become an alternative approach for controlling harmful algae in aquatic systems. Seaweeds have received attention from scientists because of their bioactive compounds with antibacterial, antifungal, anti-microalgae, and antioxidant properties. The undesirable effects of cyanobacteria proliferations and potential control methods are here reviewed, focusing on the use of potent bioactive compounds, isolated from seaweeds, against microalgae and cyanobacteria growth.
Enhanced Compressive Property of Al Composite Foams at Elevated Temperatures via Plasma Electrolytic Oxidation
Authors: Liu Huamin , Pan Wenchi , Si Fujian , Huang Kuo , Liu Yan , Liu Jiaan
Published: February 2018

The present work investigates the compressive property of Al matrix composite foams at different temperatures between room temperature and 200 °C. Elevated temperature results in a decreased compressive strength and energy absorption capacity of as-received Al foams. Therefore, to maintain the compressive property, the Al2O3 ceramic coating was deposited on the Al struts of the foams by the plasma electrolytic oxidation (PEO) process to form Al2O3/Al composite foams. As a consequence, the composite foams exhibit a higher compressive strength and energy absorption capacity as compared with the as-received Al foams at both room temperature and elevated temperatures because of the reinforced effect of the Al2O3 ceramic on the foam strut. The related mechanisms were explained by fractography, microstructure observation and phase composition analysis using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD).
Biomarkers’ Responses to Reductive Dechlorination Rates and Oxygen Stress in Bioaugmentation Culture KB-1TM
Authors: Heavner Gretchen , Mansfeldt Cresten , Debs Garrett , Hellerstedt Sage , Rowe Annette , Richardson Ruth
Published: February 2018

Using mRNA transcript levels for key functional enzymes as proxies for the organohalide respiration (OHR) rate, is a promising approach for monitoring bioremediation populations in situ at chlorinated solvent-contaminated field sites. However, to date, no correlations have been empirically derived for chlorinated solvent respiring, Dehalococcoides mccartyi (DMC) containing, bioaugmentation cultures. In the current study, genome-wide transcriptome and proteome data were first used to confirm the most highly expressed OHR-related enzymes in the bioaugmentation culture, KB-1TM, including several reductive dehalogenases (RDases) and a Ni-Fe hydrogenase, Hup. Different KB-1™ DMC strains could be resolved at the RNA and protein level through differences in the sequence of a common RDase (DET1545-like homologs) and differences in expression of their vinyl chloride-respiring RDases. The dominant strain expresses VcrA, whereas the minor strain utilizes BvcA. We then used quantitative reverse-transcriptase PCR (qRT-PCR) as a targeted approach for quantifying transcript copies in the KB-1TM consortium operated under a range of TCE respiration rates in continuously-fed, pseudo-steady-state reactors. These candidate biomarkers from KB-1TM demonstrated a variety of trends in terms of transcript abundance as a function of respiration rate over the range: 7.7 × 10−12 to 5.9 × 10−10 microelectron equivalents per cell per hour (μeeq/cell∙h). Power law trends were observed between the respiration rate and transcript abundance for the main DMC RDase (VcrA) and the hydrogenase HupL (R2 = 0.83 and 0.88, respectively), but not transcripts for 16S rRNA or three other RDases examined: TceA, BvcA or the RDase DET1545 homologs in KB1TM. Overall, HupL transcripts appear to be the most robust activity biomarker across multiple DMC strains and in mixed communities including DMC co-cultures such as KB1TM. The addition of oxygen induced cell stress that caused respiration rates to decline immediately (>95% decline within one hour). Although transcript levels did decline, they did so more slowly than the respiration rate observed (transcript decay rates between 0.02 and 0.03 per hour). Data from strain-specific probes on the pangenome array strains suggest that a minor DMC strain in KB-1™ that harbors a bvcA homolog preferentially recovered following oxygen stress relative to the dominant, vcrA-containing strain.
Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice
Authors: Chi Liang , Bian Xiaoming , Gao Bei , Tu Pengcheng , Lai Yunjia , Ru Hongyu , Lu Kun
Published: February 2018

Although artificial sweeteners are widely used in food industry, their effects on human health remain a controversy. It is known that the gut microbiota plays a key role in human metabolism and recent studies indicated that some artificial sweeteners such as saccharin could perturb gut microbiome and further affect host health, such as inducing glucose intolerance. Neotame is a relatively new low-caloric and high-intensity artificial sweetener, approved by FDA in 2002. However, the specific effects of neotame on gut bacteria are still unknown. In this study, we combined high-throughput sequencing and gas chromatography–mass spectrometry (GC-MS) metabolomics to investigate the effects of neotame on the gut microbiome and fecal metabolite profiles of CD-1 mice. We found that a four-week neotame consumption reduced the alpha-diversity and altered the beta-diversity of the gut microbiome. Firmicutes was largely decreased while Bacteroidetes was significantly increased. The Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) analysis also indicated that the control mice and neotame-treated mice have different metabolic patterns and some key genes such as butyrate synthetic genes were decreased. Moreover, neotame consumption also changed the fecal metabolite profiles. Dramatically, the concentrations of multiple fatty acids, lipids as well as cholesterol in the feces of neotame-treated mice were consistently higher than controls. Other metabolites, such as malic acid and glyceric acid, however, were largely decreased. In conclusion, our study first explored the specific effects of neotame on mouse gut microbiota and the results may improve our understanding of the interaction between gut microbiome and neotame and how this interaction could influence the normal metabolism of host bodies.
Aged Oolong Tea Reduces High-Fat Diet-Induced Fat Accumulation and Dyslipidemia by Regulating the AMPK/ACC Signaling Pathway
Authors: Yuan Erdong , Duan Xuefei , Xiang Limin , Ren Jiaoyan , Lai Xingfei , Li Qiuhua , Sun Lingli , Sun Shili
Published: February 2018

While oolong tea (OT) has been shown to induce weight loss and reduce fat accumulation, the mechanisms remain poorly defined, especially for aged OT. In this study, five groups of mice (n = 9/group) were used including a normal diet with vehicle treatment, and a high-fat diet (HFD) with vehicle or the water extracts from aged OTs (EAOTs, three different storage years) by oral gavage at 1000 mg/kg·BW for 6 weeks. Body weight, fat accumulation, and serum biochemical parameters were used to evaluate obesity. The morphology of hepatocytes and adipocytes was analyzed by being stained with hematoxylin and eosin. The levels of p-AMPK, p-ACC (and non-phosphorylated versions), CPT-1 and FAS were determined by Western blotting and immunohistochemistry. EAOTs decreased HFD-induced body weight, fat accumulation, serum levels of triglyceride, total cholesterol, and low-density lipoprotein cholesterol, while enhancing the serum high-density lipoprotein cholesterol level. At the same time, EAOTs clearly alleviated fatty liver and reduced the size of adipocytes in the epididymal fat, especially in the 2006 group. Most importantly, EAOTs increased the phosphorylation of AMPK and ACC, and up-regulated the expression of CPT-1 but down-regulated the expression of fatty acid synthase, TNF-α and iNOS. Thus, EAOTs may inhibit obesity by up-regulating energy expenditure and fatty acid oxidation while inhibiting fatty acid synthesis and inflammation.
Microbiological Values of Rainwater Harvested in Adelaide
Authors: Chubaka Chirhakarhula , Whiley Harriet , Edwards John , Ross Kirstin
Published: February 2018

In Australia, rainwater is an important source of water for many households. Unlike municipal water, rainwater is often consumed untreated. This study investigated the potential contamination of rainwater by microorganisms. Samples from 53 rainwater tanks across the Adelaide region were collected and tested using Colilert™ IDEXX Quanti-Tray*/2000. Twenty-eight out of the 53 tanks (53%) contained Escherichia coli. Samples collected from ten tanks contained E. coli at concentrations exceeding the limit of 150 MPN/100 mL for recreational water quality. A decline in E. coli was observed in samples collected after prolonged dry periods. Rainwater microbiological values depended on the harvesting environment conditions. A relationship was found between mounted TV antenna on rooftops and hanging canopies; and E. coli abundance. Conversely, there was no relationship between seasonality and E. coli or roof and tank structure materials and E. coli. In several tanks used for drinking water, samples collected prior to and after filtration showed that the filtration systems were not always successful at completely removing E. coli. These results differed from a study undertaken in the laboratory that found that a commercially available in-bench 0.45 µm filter cartridge successfully reduced E. coli in rainwater to 0 MPN/100 mL. After running a total of 265 L of rainwater which contained high levels of E. coli through the filter (half of the advertised filter lifespan), the filter cartridge became blocked, although E. coli remained undetected in filtered water. The difference between the laboratory study and field samples could be due to improper maintenance or installation of filters or recontamination of the faucet after filtration. The presence of E. coli in water that is currently used for drinking poses a potential health concern and indicates the potential for contamination with other waterborne pathogens.
Barriers and Facilitators of Partner Treatment of Chlamydia: A Qualitative Investigation with Prescribers and Community Pharmacists
Authors: Wood Helen , Hall Caroline , Ioppolo Emma , Ioppolo Renée , Scacchia Ella , Clifford Rhonda , Gudka Sajni
Published: February 2018

Chlamydia trachomatis is the most frequently-notified sexually transmitted infection in Australia. Effective and timely partner treatment of chlamydia is essential to reduce overall prevalence and the burden of infection. Currently in most of Australia, the only avenue for partner treatment of chlamydia (“standard partner therapy”) is a tedious, and often inconvenient, process. The barriers and facilitators of standard partner therapy, and newer models of accelerated partner therapy (APT), need to be identified in the Australian setting. Additionally, the potential role of community pharmacists need to be explored. Semi-structured interview guides for two key stakeholder groups (prescribers and pharmacists) were developed and piloted. Eleven prescribers (general practitioners, sexual health clinicians and nurse practitioners) and twelve pharmacists practicing in the Perth metropolitan region were interviewed. Key reported barriers to standard partner therapy were lack of or delayed chlamydia testing. Key facilitators included ability to test and educate sexual partner. Key barriers for APT included prescribers’ legal responsibility and potential for medication-related adverse effects. Healthcare provider consultation and chlamydia testing were seen as potential facilitators of APT. Pharmacists were receptive to the idea of expanding their role in chlamydia treatment, however, barriers to privacy must be overcome in order to be acceptable to prescribers and pharmacists.
Anion-Controlled Architecture and Photochromism of Naphthalene Diimide-Based Coordination Polymers
Authors: Liu Jian-Jun , Xia Shu-Biao , Duan Yu-Lian , Liu Teng , Cheng Fei-Xiang , Sun Cheng-Ke
Published: February 2018

Three new cadmium coordination polymers, namely [Cd(NO3)2(DPNDI)(CH3OH)]·CH3OH (1), [Cd(SCN)2(DPNDI)] (2), and [Cd(DPNDI)2(DMF)2]·2ClO4 (3) (DPNDI = N,N-di(4-pyridyl)-1,4,5,8-naphthalene diimide, DMF = N,N-dimethylformamide) have been synthesized by reactions of DPNDI with Cd(NO3)2, Cd(SCN)2, and Cd(ClO4)2, respectively. Compound 1 is a one-dimensional coordination polymer with strong lone pair-π interactions between the coordinated NO3− anions and the imide ring of DPNDI; while 2 is a two-dimensional network with a (4, 4) net topology. In the case of 3, due to the presence of uncoordinated perchlorate counter ions, it exhibits a non-interpenetrated square-grid coordination polymer containing one-dimensional rhomboid channels. The structural diversity in these compounds is attributed to different coordination abilities and geometries of counter anions. Due to the presence of electron-deficient NDI moiety, the photochromic behavior of these compounds was studied. Interestingly, only compounds 1 and 3 exhibit color changes under light irradiation. The influence of the anions on the photochromism process of the NDI-based materials has been discussed.
Process Modification of Pharmaceutical Tablet Manufacturing Operations: An Eco-Efficiency Approach
Authors: Hindiyeh Muna , Altalafha Tala , Al-Naerat Manar , Saidan Hakam , Al-Salaymeh Ahmed , Sbeinati Lu’ay , Saidan Motasem
Published: February 2018

A process improvement in a tablet manufacturing process within a pharmaceutical industry was carried out based on an eco-efficiency approach. As it is one of the most energy consuming processes in the production line, the tablet manufacturing process was considered. It has the highest production volume with a complicated and long manufacturing product life cycle. Data were collected on energy inputs and emissions data for the stages of powder direct mixing, particle size reduction, and tableting. A straightforward approach was then used to analyze environmental impacts in terms of GHG emissions. Non- added value steps were removed from the product life cycle process, which has led to significant time and cost savings, as well as to a reduction in the emission. Annual economic savings have been achieved, a time reduction of approximately 71% was attained, and the reduction in GHG emissions and energy cost were 73.2%. The g CO2eq per tablet reduction has been calculated within the process improvement to be 2.06 g CO2eq per tablet instead of 7.71 g CO2eq per tablet.
Elephant and Mammoth Hunting during the Paleolithic: A Review of the Relevant Archaeological, Ethnographic and Ethno-Historical Records
Authors: Agam Aviad , Barkai Ran
Published: February 2018

Proboscideans and humans have shared habitats across the Old and New Worlds for hundreds of thousands of years. Proboscideans were included in the human diet starting from the Lower Paleolithic period and until the final stages of the Pleistocene. However, the question of how prehistoric people acquired proboscideans remains unresolved. Moreover, the effect of proboscidean hunting on the eventual extinction of these mega-herbivores was never seriously evaluated, probably because of the lack of acquaintance with the plethora of information available regarding proboscidean hunting by humans. The aim of this paper is to bridge this gap and bring to light the data available in order to estimate the extent and procedures of elephant and mammoth hunting by humans during the Quaternary. This study examines the archaeological evidence of proboscidean hunting during Paleolithic times, and provides a review of ethnographic and ethno-historical accounts, demonstrating a wide range of traditional elephant-hunting strategies. We also discuss the rituals accompanying elephant hunting among contemporary hunter-gatherers, further stressing the importance of elephants among hunter-gatherers. Based on the gathered data, we suggest that early humans possessed the necessary abilities to actively and regularly hunt proboscideans; and performed this unique and challenging task at will.
Health Care Workers’ Risk Perceptions and Willingness to Report for Work during an Influenza Pandemic
Authors: Dionne Georges , Desjardins Denise , Lebeau Martin , Messier Stéphane , Dascal André
Published: February 2018

The ability and willingness of health care workers to report for work during a pandemic are essential to pandemic response. The main contribution of this article is to examine the relationship between risk perception of personal and work activities and willingness to report for work during an influenza pandemic. Data were collected through a quantitative Web-based survey sent to health care workers on the island of Montreal. Respondents were asked about their perception of various risks to obtain index measures of risk perception. A multinomial logit model was applied for the probability estimations, and a factor analysis was conducted to compute risk perception indexes (scores). Risk perception associated with personal and work activities is a significant predictor of intended presence at work during an influenza pandemic. This means that correcting perceptual biases should be a public policy concern. These results have not been previously reported in the literature. Many organizational variables are also significant.
An Object Similarity-Based Thresholding Method for Urban Area Mapping from Visible Infrared Imaging Radiometer Suite Day/Night Band (VIIRS DNB) Data
Authors: Ma Wenting , Li Peijun
Published: February 2018

Nighttime light data from the Visible Infrared Imaging Radiometer Suite (VIIRS) Day/Night Band (DNB) provides a unique data source for mapping and monitoring urban areas at regional and global scales. This study proposes an object similarity-based thresholding method using VIIRS DNB data to map urban areas. The threshold for a target potential urban object was determined by comparing its similarity with all reference urban objects with known optimal thresholds derived from Landsat data. The proposed method includes four major steps: potential urban object generation, threshold optimization for reference urban objects, object similarity comparison, and urban area mapping. The proposed method was evaluated using VIIRS DNB data of China and compared with existing mapping methods in terms of threshold estimation and urban area mapping. The results indicated that the proposed method estimated thresholds and mapped urban areas accurately and generally performed better than the cluster-based logistic regression method. The correlation coefficients between the estimated thresholds and the reference thresholds were 0.9201–0.9409 (using Euclidean distance as similarity measure) and 0.9461–0.9523 (using Mahalanobis distance as similarity measure) for the proposed method and 0.9435–0.9503 for the logistic regression method. The average Kappa Coefficients of the urban area maps were 0.58 (Euclidean distance) and 0.57 (Mahalanobis distance) for the proposed method and 0.51 for the logistic regression method. The proposed method shows potential to map urban areas at a regional scale effectively in an economic and convenient way.
Chlorophyll-a Concentration Retrieval in the Optically Complex Waters of the St. Lawrence Estuary and Gulf Using Principal Component Analysis
Authors: Laliberté Julien , Larouche Pierre , Devred Emmanuel , Craig Susanne
Published: February 2018

Empirical methods based on band ratios to infer chlorophyll-a concentration by satellite do not perform well over the optically complex waters of the St. Lawrence Estuary and Gulf. Using a dataset of 93 match-ups, we explore an alternative method relying on empirical orthogonal functions (EOF) to develop an algorithm that relates the satellite-derived remote sensing reflectances to in situ chlorophyll-a concentration for the Sea-viewing Wide Field-of-view Sensor (SeaWiFS). Results show that an accuracy of 41% at retrieving chlorophyll-a concentration can be reached using the EOF method compared to 140% for the widely-used Ocean Chlorophyll 4 (OC4v4) empirical algorithm, 53% for the Garver-Siegel-Maritorena (GSM01) and 54% for the Generalized Inherent Optical Property (GIOP) semi-analytical algorithms. This result is possible because the EOF approach is able to extract region-specific radiometric features from the satellite remote sensing reflectances that are related to absorption properties of optical components (water, coloured dissolved organic matter and chlorophyll-a) using the visible SeaWiFS channels. The method could easily be used with other ocean-colour satellite sensors (e.g., MODIS, MERIS, VIIRS, OLCI) to extend the time series for the St. Lawrence Estuary and Gulf waters.
Investigating Arctic Sea Ice Survivability in the Beaufort Sea
Authors: Tooth Matthew , Tschudi Mark
Published: February 2018

Arctic sea ice extent has continued to decline in recent years, and the fractional coverage of multi-year sea ice has decreased significantly during this period. The Beaufort Sea region has been the site of much of the loss of multi-year sea ice, and it continues to play a large role in the extinction of ice during the melt season. We present an analysis of the influence of satellite-derived ice surface temperature, ice thickness, albedo, and downwelling longwave/shortwave radiation as well as latitude and airborne snow depth estimates on the change in sea ice concentration in the Beaufort Sea from 2009 to 2016 using a Lagrangian tracking database. Results from this analysis indicate that parcels that melt during summer in the Beaufort Sea reside at lower latitudes and have lower ice thickness at the beginning of the melt season in most cases. The influence of sea ice thickness and snow depth observed by IceBridge offers less conclusive results, with some years exhibiting higher thicknesses/depths for melted parcels. Parcels that melted along IceBridge tracks do exhibit lower latitudes and ice thicknesses, however, which indicates that earlier melt and breakup of ice may contribute to a greater likelihood of extinction of parcels in the summer.
Detection of Land Subsidence Associated with Land Creation and Rapid Urbanization in the Chinese Loess Plateau Using Time Series InSAR: A Case Study of Lanzhou New District
Authors: Chen Guan , Zhang Yi , Zeng Runqiang , Yang Zhongkang , Chen Xi , Zhao Fumeng , Meng Xingmin
Published: February 2018

Lanzhou New District is the first and largest national-level new district in the Loess Plateau region of China. Large-scale land creation and rapid utilization of the land surface for construction has induced various magnitudes of land subsidence in the region, which is posing an increasing threat to the built environment and quality of life. In this study, the spatial and temporal evolution of surface subsidence in Lanzhou New District was assessed using Persistent Scatterer Interferometric Synthetic Aperture radar (PSInSAR) to process the ENVISAT SAR images from 2003–2010, and the Small Baseline Subset (SBAS) InSAR to process the Sentinel-1A images from 2015–2016. We found that the land subsidence exhibits distinct spatiotemporal patterns in the study region. The spatial pattern of land subsidence has evidently extended from the major urban zone to the land creation region. Significant subsidence of 0–55 mm/year was detected between 2015 and 2016 in the land creation and urbanization area where either zero or minor subsidence of 0–17.2 mm/year was recorded between 2003 and 2010. The change in the spatiotemporal pattern appears to be dominated mainly by the spatial heterogeneity of land creation and urban expansion. The spatial associations of subsidence suggest a clear geological control, in terms of the presence of compressible sedimentary deposits; however, subsidence and groundwater fluctuations are weakly correlated. We infer that the processes of land creation and rapid urban construction are responsible for determining subsidence over the region, and the local geological conditions, including lithology and the thickness of the compressible layer, control the magnitude of the subsidence process. However, anthropogenic activities, especially related to land creation, have more significant impacts on the detected subsidence than other factors. In addition, the higher collapsibility and compressibility of the loess deposits in the land creation region may be the underlying mechanism of macro-subsidence in Lanzhou New District. Our results provide a useful reference for land creation, urban planning and subsidence mitigation in the Loess Plateau region, where the large-scale process of bulldozing mountains and valley infilling to create level areas for city construction is either underway or forthcoming.
Ionizing Radiation Measurement Solution in a Hospital Environment
Authors: Garcia-Sanchez Antonio-Javier , Garcia Angosto Enrique , Moreno Riquelme Pedro , Serna Berna Alfredo , Ramos-Amores David
Published: February 2018

Ionizing radiation is one of the main risks affecting healthcare workers and patients worldwide. Special attention has to be paid to medical staff in the vicinity of radiological equipment or patients undergoing radioisotope procedures. To measure radiation values, traditional area meters are strategically placed in hospitals and personal dosimeters are worn by workers. However, important drawbacks inherent to these systems in terms of cost, detection precision, real time data processing, flexibility, and so on, have been detected and carefully detailed. To overcome these inconveniences, a low cost, open-source, portable radiation measurement system is proposed. The goal is to deploy devices integrating a commercial Geiger-Muller (GM) detector to capture radiation doses in real time and to wirelessly dispatch them to a remote database where the radiation values are stored. Medical staff will be able to check the accumulated doses first hand, as well as other statistics related to radiation by means of a smartphone application. Finally, the device is certified by an accredited calibration center, to later validate the entire system in a hospital environment.
OSCANN: Technical Characterization of a Novel Gaze Tracking Analyzer
Authors: Hernández Erik , Hernández Santiago , Molina David , Acebrón Rafael , García Cena Cecilia
Published: February 2018

Eye-movement analysis has grown exponentially in recent decades. The reason is that abnormalities in oculomotor movements are usually symptoms of injuries in the nervous system. This paper presents a novel regulated solution named OSCANN. OSCANN aims at providing an innovative tool for the control, management and visualization of oculomotor neurological examinations. This solution utilizes an eye-tracker sensor based on video electro-oculography (VOG) technology to capture eye movements and store them in video files. Such a sensor can store images at a rate of 100 frames per second. A characterization study was performed using twenty-two volunteers (13 male, 9 female, ages 22–45 years, mean 29.3 years, SD = 6.7) to assess the accuracy and precision specifications of OSCANN during oculomotor movement analysis. The accuracy was evaluated based on the offset, whereas precision was estimated with Root Means Square (RMS). Such a study reported values lower than 0.4 ∘ and 0.03 ∘ of accuracy and precision, respectively. These results suggest that OSCANN can be considered as a powerful tool to measure oculomotor movement alterations involved in some neurological disease progression.
Sustainable Entrepreneurship Orientation: A Reflection on Status-Quo Research on Factors Facilitating Responsible Managerial Practices
Authors: Kraus Sascha , Burtscher Janina , Vallaster Christine , Angerer Martin
Published: February 2018

With the global financial system having undergone vast changes since the financial crisis of 2007, scientific research concerning the investor’s point of view on sustainable investments has drastically increased. However, there remains a lack of research focused on the entrepreneur’s angle regarding sustainable oriented investments. The aim of this paper is to contribute to the understanding of sustainable financial markets by bringing together entrepreneurial and financial research. This paper provides a structured literature review, based on which the authors identify three relevant levels that they believe have an effect on the successful implementation of managerial sustainable practices; these are the individual, the firm, and the contextual levels. The results show that on the individual level sustainable entrepreneurs tend to derive their will to act more sustainably from their personal values or traits. On the organizational level, though, it can be concluded that an small and medium sized enterprise’s internal culture and the reconfiguration of resources are critical determinants for adopting a sustainable entrepreneurial orientation. Finally, on the contextual level, researchers have focused on a better understanding of how entrepreneurs can help society and the environment through sustainable entrepreneurship, and how they can act as role models or change agents in light of the fact that the choice of investing or financing based on sustainability is still in its infancy. By providing an overview on facilitating factors for responsible managerial practices on the entrepreneur’s side, this research contributes to a better understanding for both theory and practice on how sustainable practices can be implemented and facilitated.
“Green Ocean Treasure Hunting” Guided by Policy Support in a Transitional Economy
Authors: Ge Baoshan , Sheng Fan , Gao Yang , Tsai Sang-Bing , Du Xiaomin
Published: February 2018

For countries in the process of economic transition, improvement of industrialization is no longer the sole goal of their economic development. While upgrading the level of industrial development, these countries also gradually attach importance to resource utilization efficiency and environmental protection, which is why green entrepreneurship has become increasingly popular in recent years. With the intensification of policy guidance, a new “sea area” named green entrepreneurship ushers in more and more “treasure hunters” exploring “the treasure” therein. Based on this, this paper constructs the model of “Green Ocean Treasure Hunting” for green entrepreneurial enterprises to analyze the role played by their government’s relevant policies and puts forward the research proposition of this article based on the relevant literature. On this basis, this paper chooses and analyzes a medium-sized, high-tech enterprise in China which follows a certain typical green entrepreneurial process as evidence of the propositions we have put forward.
Environmental Orientation in Swedish Local Governments
Authors: Alpenberg Jan , Wnuk-Pel Tomasz , Henebäck Amanda
Published: February 2018

This study explores the environmental orientation in Swedish local governments. Environmental concerns over potential risk factors have become more important and popular among public organizations and environmental improvement efforts are made to create a sustainable ecosystem for the actors doing business, living and working in the area. Prior research indicates that public organizations have started to become more environmentally oriented in order to take on more responsibilities for reducing their own environmental impact as well as influencing the citizens and local businesses in the direction of a more sustainable way of living and working. Through a survey of Swedish local governments we conclude that they are taking on a key role in developing a sustainable ecosystem through becoming more environmentally oriented. This includes developing a framework for setting environmental goals, identifying suitable environmental indicators and reporting to a wide range of stakeholders. A factor that explains the increasing environmental orientation in the public sector is the implementation of digitalized performance measurement systems. We find that the environmental performance measurements are used to motivate different internal and external stakeholders in the efforts to create a multi-actor ecosystem.
Taking the First Steps beyond GDP: Maryland’s Experience in Measuring “Genuine Progress”
Authors: Hayden Anders , Wilson Jeffrey
Published: February 2018

Gross Domestic Product’s (GDP) limitations as a prosperity indicator are now widely recognized, leading to a search for “beyond-GDP” alternatives. The US state of Maryland has calculated one such alternative, the Genuine Progress Indicator (GPI), since 2010. What effect is Maryland’s GPI having in practice? Is there any evidence to date that the GPI has shaped policy and public priorities in ways that live up to its supporters’ hopes—whether for a transformative shift beyond the economic-growth paradigm or simply better policymaking? What key obstacles exist to fulfilling those goals? This article draws on semi-structured interviews with elite respondents—including Maryland’s former governor, senior public servants, academics, non-governmental organization employees and foundation leaders—involved in producing, advocating and using the GPI, along with analysis of relevant documents. Although significant impacts on policy are not yet evident and a change of governor has removed high-level support, the GPI initiative has revealed innovative possibilities for more environmentally and socially minded policymaking and introduced new ideas with potential long-term impacts. However, various challenges remain, including strengthening the political constituency behind the GPI, more deeply embedding it into the policymaking process and addressing the GPI’s own limitations in supporting a beyond-GDP economic narrative.
Surface Modification of Polystyrene with O Atoms Produced Downstream from an Ar/O2 Microwave Plasma
Authors: Li Xinyun , Lu Fei , Cocca Matthew , Vega Katerine , Fleischer Andrew , Bailey Alla , Toro Marc , Sachdev Shreen , Debies Thomas , Mehan Michael , Gupta Surendra , Takacs Gerald
Published: February 2018

Because discarded polystyrene (PS) is little affected by degrading agents, PS was treated with a remote microwave (MW) plasma discharge of an Ar/O2 mixture in the absence of radiation to increase wettability and introduce functional groups which make the waste more liable to degradation and useful for technological applications. X-ray photoelectron spectroscopy (XPS) detected decreases in the aromatic sp2 and aliphatic sp3 carbons with treatment and, initially, increases in C–O and carbonyl groups, present in the formation of ethers, epoxides, alcohols, ketones and aldehydes. At longer treatment times, ester, O–C=O; carbonate-like, O–(C=O)–O; and anhydride, O=C–O–C=O; moieties are observed with an overall oxygen saturation level of 23.6 ± 0.9 at% O. Atomic Force Microscopy (AFM) measurements detected little change in surface roughness with treatment time. Advancing water contact angle decreased by ca. 50% compared to pristine PS indicating an increase in hydrophilicity because of oxidation. Washing the treated samples in deionized water decreased the oxygen concentrations at the saturation treatment times down to 18.6 ± 1 at% O due to the washing away of a weak boundary layer.
Proposal for a Monitoring Concept for Veterinary Medicinal Products with PBT Properties, Using Parasiticides as a Case Study
Authors: Römbke Jörg , Duis Karen
Published: February 2018

The aim of this work is to prepare a proposal for the post-authorization monitoring (PAM) of veterinary medicinal products (VMP), in particular parasiticides. Such a monitoring might especially be useful for parasiticides identified as Persistence Bioaccumulation Toxicity (PBT) substances, i.e., chemicals that are toxic (T), persist in the environment (P) and bioaccumulate (B) in food chains and, thus, pose a hazard to ecosystems. Based on a literature search, issues to be considered when performing such a PAM are discussed (e.g., residue analysis, compartments to be included, selection of organisms and the duration of monitoring studies). The outcome of this discussion is that—and despite that there are huge challenges in detail (e.g., in terms of analytical chemistry or taxonomy)—the technical performance of such a PAM is not the main problem, since most of the chemical and biological methods to be used are well-known (partly even standardized) or could be adapted. However, it is very difficult to define in detail where and when a monitoring should be performed. The main problem is to link exposure to effects of a certain parasiticide in a way that any impact can directly be related to the use of this parasiticide. Therefore, a “Targeted Environmental Monitoring” (TEM) is proposed, which is essentially a combination between a field study and a PAM.
Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection
Authors: Chanthick Chanettee , Suttitheptumrong Aroonroong , Rawarak Nantapon , Pattanakitsakul Sa-nga
Published: February 2018

The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage. Properly functioning endothelial cells promote physiological balance and stability for blood circulation and fluid components. A monolayer of endothelial cells has the ability to regulate paracellular and transcellular pathways for transport proteins, solutes, and fluid. In addition to the paracellular pathway, the transcellular pathway is another route of endothelial permeability that mediates vascular permeability under physiologic conditions. The transcellular pathway was found to be associated with an assortment of disease pathogeneses. The clinical manifestation of severe dengue infection in humans is vascular leakage and hemorrhagic diatheses. This review explores and describes the transcellular pathway, which is an alternate route of vascular permeability during dengue infection that corresponds with the pathologic finding of intact tight junction. This pathway may be the route of albumin transport that causes endothelial dysfunction during dengue virus infection.
Favipiravir and Ribavirin Inhibit Replication of Asian and African Strains of Zika Virus in Different Cell Models
Authors: Kim Ji-Ae , Seong Rak-Kyun , Kumar Mukesh , Shin Ok
Published: February 2018

Zika virus (ZIKV) has recently emerged as a new public health threat. ZIKV infections have caused a wide spectrum of neurological diseases, such as Guillain–Barré syndrome, myelitis, meningoencephalitis, and congenital microcephaly. No effective therapies currently exist for treating patients infected with ZIKV. Herein, we evaluated the anti-viral activity of favipiravir (T-705) and ribavirin against Asian and African strains of ZIKV using different cell models, including human neuronal progenitor cells (hNPCs), human dermal fibroblasts (HDFs), human lung adenocarcinoma cells (A549) and Vero cells. Cells were treated with favipiravir or ribavirin and effects on ZIKV replication were determined using quantitative real-time PCR and plaque assay. Our results demonstrate that favipiravir or ribavirin treatment significantly inhibited ZIKV replication in a dose-dependent manner. Moreover, favipiravir treatment of ZIKV-infected hNPCs led to reduced cell death, enhanced AKT pathway phosphorylation, and increased expression of anti-apoptotic factor B cell lymphoma 2. In conclusion, our results demonstrate conclusively that favipiravir inhibits ZIKV replication and prevents cell death, and can be a promising intervention for ZIKV-associated disease.
Typical Lateral Interactions, but Increased Contrast Sensitivity, in Migraine-With-Aura
Authors: Asher Jordi , O’Hare Louise , Romei Vincenzo , Hibbard Paul
Published: February 2018

Individuals with migraine show differences in visual perception compared to control groups. It has been suggested that differences in lateral interactions between neurons might account for some of these differences. This study seeks to further establish the strength and spatial extent of excitatory and inhibitory interactions in migraine-with-aura using a classic lateral masking task. Observers indicated which of two intervals contained a centrally presented, vertical Gabor target of varying contrast. In separate blocks of trials, the target was presented alone or was flanked by two additional collinear, high contrast Gabors. Flanker distances varied between 1 and 12 wavelengths of the Gabor stimuli. Overall, contrast thresholds for the migraine group were lower than those in the control group. There was no difference in the degree of lateral interaction in the migraine group. These results are consistent with the previous work showing enhanced contrast sensitivity in migraine-with-aura for small, rapidly presented targets, and they suggest that impaired performance in global perceptual tasks in migraine may be attributed to difficulties in segmenting relevant from irrelevant features, rather than altered local mechanisms.