bluuebunny/crossref_metadata_2025 huggingface dataset:
GAZETECİLİĞİN LİSANSÜSTÜ DÜZEYDE İNCELENMESİ: 2018 – 2023 YILLARI ARASINDA YAZILAN GAZETECİLİK KONULU TEZLER ÜZERİNE BİR ARAŞTIRMA
Authors: YENİCELER KORTAK İrem
Published: December 2023

Gazetecilik, oldukça eski tarihlerden günümüze kadar gelen bir kavramdır. Tarihsel süreç içerisinde gazeteciliğin biçim ve içerik olarak farklı değişimler geçirdiği görülmektedir. Söz konusu değişimler, gazetecilik alanındaki araştırmaların da konusunu ve sayısını da etkilemiştir. Gazeteciliğe yönelik gerçekleştirilen ilk araştırmalar, bir kavram olarak gazetenin ne olduğu ve gazetecinin kimliğinin nasıl çerçeveleneceği üzerinde durmuştur. Teknolojinin ilerleme göstermesinin beraberinde gazetecilik üzerine yapılan çalışmalar da farklılık göstermiştir. Özellikle yeni medya ortamlarının ortaya çıkmasıyla birlikte gazetecilik, farklı mecralar üzerinden gerçekleştirilen ve çeşitli türlere ayrılabilen bir kavram haline gelmiştir. Gazeteciliğin şemsiye bir kavram olarak değerlendirilebilmesi, alana yönelik yapılan çalışmalar üzerinde de etkili olmuştur. Bu sebeple çalışma, gazetecilik alanındaki araştırmaların yıllara göre ne şekilde değişiklik gösterdiğini incelemeyi amaçlamaktadır. Çalışmanın amacına uygun olması açısından YÖK Ulusal Tez Merkezi üzerinden “Gazetecilik” konusu üzerinden 2018 Ocak ayı ile 2023 Ağustos ayı arasında yayımlanan yüksek lisans ve doktora tezleri incelenmiştir. İlgili tarih aralığında toplamda 1484 tezin yayımlandığı görülmüş ve söz konusu tezler içerik analizi yöntemi ile analiz edilmiştir. Gerçekleştirilen araştırma sonucunda; gazetecilik konulu tezlerin sayısal anlamda doktora ve yüksek lisans düzeylerinde farklılaştığı, tezlerin her iki düzeyde de ağırlıklı olarak Türkçe hazırlandığı, üniversitelerin gazetecilik ana bilim dallarında konuyla ilgili en çok sayıda tezin hazırlandığı ve tezlerin ağırlıklı olarak devlet üniversitelerine bağlı enstitüler üzerinden oluşturulduğu saptanmıştır.
Pedagogical Design Matters: Integrating Engineering Design and Knowledge Building for Undergraduates to Practice and Improve Computational Thinking Skills
Authors: Zhu Gaoxia , Kow Jason Fok , Fan Xiuyi , Chit Lin Su , Ong Yew Soon
Published: December 2023

In this digitalized, data-driven era, developing computational thinking (CT) skills is crucial for individuals to interact with computers and leverage their computing capabilities. Engineering design processes provide students with a context for applying and developing CT skills. Knowledge Building/Creation is a pedagogical approach that supports students to improve design ideas and products continuously. However, how students apply and develop CT skills through the engineering design process remains unclear, especially in a knowledge-creation community. This study collected design reports and presentation slides from 62 undergraduate students working in 13 small groups. Through manual coding, GPT-4 multilabel classification and narrative analysis, we examined what and how CT skills were demonstrated in the reports and slides and how playing the roles of designers and users influenced undergraduates' design. We found that the participants demonstrated five CT skills with differing frequencies and needed more support in troubleshooting; they could improve their design across the three design iterations. Having users in mind during design made them intentionally design more complex products while considering the design requirements. The findings suggested the need to specifically support students to troubleshoot and provide and receive feedback to improve their design further and the feasibility of using GPT to analyze CT skills manifested in students' reports.
Hubungan Antara Kecemasan dengan Kejadian Sleep Paralysis pada Mahasiswa Tingkat Akhir
Authors: Kurniasari Fatriana , Nurfitria Siti , Istiqomah Nur , Murniati Anis
Published: December 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara kecemasan dengan kejadian sleep paralysis pada mahasiswa tingkat akhir. Pengumpulan data yang digunakan dalam penelitian ini menggunakan skala kecemasan dan skala sleep paralysis. Metode analisis data yang digunakan dalam penelitian ini yaitu uji Chi Square. Hasil uji chi square menunjukkan nilai p= 0,000 (p< 0,05) yang artinya terdapat hubungan yang signifikan antara kecemasan dengan kejadian sleep paralysis pada mahasiswa tingkat akhir. Hasil penelitian juga menunjukkan bahwa responden yang memiliki tingkat kecemasan tinggi dan mengalami sleep paralysis sebanyak 19 orang (100,0%), responden yang memiliki tingkat kecemasan tinggi dan tidak mengalami sleep paralysis tidak ada (0,0%), responden yang memiliki tingkat kecemasan sedang dan mengalami sleep paralysis sebanyak 52 orang (68,4%), responden yang memiliki tingkat kecemasan sedang dan tidak mengalami sleep paralysis 24 orang (31,6%), responden yang memiliki tingkat kecemasan rendah dan mengalami sleep paralysis tidak ada (0,0%), responden yang memiliki tingkat kecemasan rendah dan tidak mengalami sleep paralysis 5 orang (100,0%).
Photovoltaic and mechanical properties of boron carbide films prepared by magnetron sputtering
Authors: Nishida Tatsuya , Sato Masayoshi , Enta Yoshiharu , Suzuki Yushi , Kobayashi Yasuyuki , Nakazawa Hideki
Published: December 2023

In this study, amorphous boron carbide (B
x
C) and hydrogenated amorphous B
x
C (B
x
C:H) films were deposited via magnetron sputtering to investigate the effects of hydrogen on the film properties. The critical load decreased with increasing H2 flow ratio, probably due to an increase in the internal stress. In addition, the optical bandgap increased with the H2 flow ratio increased. The bandgap was controlled by the chemical bonding of carbon atoms and the chemical composition of films. The resistivity of the films increased with the H2 flow ratio and bandgap energy. The current–voltage characteristics of B
x
C(:H)/n-type Si heterojunctions under white light illumination showed that the short-circuit current density and open-circuit voltage were higher than the previously reported values. Results revealed that the introduction of hydrogen during deposition reduced the short-circuit current density, fill factor, and conversion efficiency, whereas the open-circuit voltage remained almost unchanged.
Constitutional Responses and Guarantees to Recent Changes in Marriage and Family Life
Authors:   Korean Constitutional Law Asscciation, Kim Jeong-Soo
Published: December 2023

Our Constitution stipulates that marriage and family life should be established and maintained on the basis of individual dignity and equality of sexes, and the state has an obligation to guarantee this.
However, recent changes in marriage and family life are occurring due to various factors of society. In Korea, too, family forms are diversifying due to the collapse of the traditional family system and various choices for freedom of marriage due to late marriage, non-marriage, graduating from marriage, and reduced fertility. Our Constitution stipulates marriage, family life and the obligation of the state to guarantee it in Article 36, but the current legal concept and constitutional response to marriage and family seems insufficient.
In order to effectively respond to this, I think it is necessary to appropriately revise marriage and family provisions when revising the constitution. The content and form of the discipline of Article 36, Paragraph 1 of the current Constitution has a limit to constitutionally embrace and guarantee the deinstitutionalization of the family in modern society because the traditional family system has a strong guarantee character.
Problem solving through the existing constitutional interpretation may be the next best thing, but in order to protect and support a new type of community that does not correspond to traditional marriage and family forms as marriage and family, it is necessary to fully consider the possibility of acceptance into our society and accept it based on constitutional possibility and grounds through consensus of the public sphere.
Furthermore, in recognizing a new type of marriage and family form, it is time to change the sense of solidarity of being a companion to live together in this age, avoiding discriminatory judgment based on preconception and prejudice on the constitutional basis.
At Home in the World Language of Modern Poetry
Authors:   Universität Vaasa, Parry Christoph
Published: December 2023

Paul Celan is probably the internationally best-known poet writing in German since World War 2. Coming from the former Romanian province of Bukovina, which had previously been part of the Austro-Hungarian Empire, he was originally regarded with scepticism by German literary critics who attributed the novelty of his work to his exotic Eastern European Jewish origins. This paper argues that after years of fascist isolation the critics initially failed to recognise that Celan’s work, far from being strangely exotic, actually represents mainstream modernity and should be seen in the context of a “World language of modern poetry” as defined by Hans Magnus Enzensberger with his anthology of international poetry Museum der modernen Poesie published in 1960. The anthology, to which Celan contributed with translations of Osip Mandel’štam, proved a landmark in the work of reconnecting West Germany with the international literary scene. The paper emphasises the importance of dialogue in Celan’s work and of his links to the tradition of international modernism.
Empirical Investigation on Influence of Employee Skill Development and Continuous Service Improvement on Service Delivery in Huduma Centres in Nairobi City County, Kenya
Authors: Nyamai Mary , Njagi Elias
Published: December 2023

Although Total Quality Management (TQM) programs help to improve customer service delivery, state-owned corporations like Kenya's Huduma Centres have continued to face significant difficulties in meeting the evolving needs of its clientele. Despite the Kenyan government's efforts to enhance the provision of public services by opening Huduma centers, empirical evidence reveal customer dissatisfaction continues to prevail. The goal of the study was to determine how overall quality management strategies affected the provision of services in Huduma Centers in Kenya's Nairobi City County. Determine the impact of employee skill development and continuous service improvement on service delivery in Huduma Centers in Nairobi City County, Kenya, was one of the study's particular goals. Theory of overall quality management served as the study's foundation and backed up by the gap analysis model and the notion of dynamic capacities. The problem was investigated using a descriptive research design in the study. The study's sample size was 185 respondents, with a target population of 343 employees from the five Huduma Centers functioning in Nairobi City County. While secondary data was gathered from documented human resource records, primary data was gathered utilizing questionnaires. The researcher will assess the research's validity by consulting with lecturers from Kenyatta University's department of business administration and experts in quality management, while the Cronbach Alpha method will be used to assess the reliability of the research instrument. While content analysis was used to evaluate qualitative data, descriptive and inferential statistics like correlation and regression were employed to study quantitative data. Tables were used to present the examined data. According to the study's findings, service delivery in Huduma Centers in Nairobi City County, Kenya, was positively impacted by employee skill development and ongoing service improvement.
A CASE OF SPONTANEOUS OVARIAN HYPERSTIMULATION SYNDROME AND PITUITARY HYPERPLASIA SECONDARY TO HYPOTHYROIDISM IN PUBERTAL GIRL
Authors: Kalpana N. , Manisha Kuntal , Premalatha P. B.
Published: December 2023

ovarian hyperstimulation syndrome is a condition usually associated with ovulation induction. Rarely a non pregnant woman or woman not on
ovulation induction treatment has been documented to develop spontaneous ovarian hyperstimulation syndrome. In this case study, we describe a
female in the pubertal age range who had spontaneous ovarian hyperstimulation and pituitary hyperplasia due to primary hypothyroidism, which
improved with thyroid replacement therapy.
RISK FACTOR ASSESSMENT, ETIOLOGY,CLINICO-RADIOLOGICAL PROFILE AND PROGNOSIS IN CVA
Authors: Krishna J. T. V. , Kumar Pavan
Published: December 2023

Background: Stroke is a signicant health concern globally, and its incidence can vary across different regions and populations. Understanding
the epidemiology and risk factors for stroke in specic regions is crucial for effective prevention and management. This study investigates the
prole of stroke patients in South India, focusing on gender disparities, risk factors, clinical features, and outcomes. Aim: To study the clinical
prole, various types and sites of stroke in the study population Materials and Methods: This observational study enrolled 100 stroke patients,
excluding those not meeting the inclusion criteria. Patients were assessed clinically, and relevant data were collected. Gender disparities, stroke
types (ischemic vs. hemorrhagic), clinical features, anatomic locations, etiological factors, and risk factors were documented. Additionally, oneweek prognoses and outcomes were evaluated. The ndings were compared to existing studies to provide context. Results: The study revealed a
28% higher incidence of stroke in males (64%) compared to females (36%), aligning with similar ndings in previous research. Ischemic strokes
predominated (88%), consistent with estimates from the American Heart Association. Hemiplegia/hemiparesis was the most common clinical
feature (72%), followed by loss of consciousness (58%) and headache (44%). Hemorrhagic stroke patients displayed more severe symptoms and
lower GCS scores. Partial Anterior Circulatory Strokes (43%) and small vessel disease (51%) were the most prevalent anatomic locations and
etiological factors, respectively. Hypertension (52%) and cigarette smoking (36%) were the most common risk factors.
Conclusion:
1. This study contributes to understanding stroke epidemiology in South India. Gender disparities, prevalence of ischemic strokes, clinical
features, anatomic locations, etiological factors, and risk factors.
2. Hemorrhagic strokes were associated with higher mortality and morbidity, underscoring the need for specialized care in this population.
3. These insights emphasize the importance of tailored prevention and management strategies in regions with unique risk factor proles and
genetic characteristics.
QUALITY OF LIFE AFTER SURGERY FOR CHRONIC PANCREATITIS- A TERTIARY CARE GOVERNMENT HOSPITAL EXPERIENCE
Authors: Sreejith P. S. , Kumar A Arun , Anbarasu Anbarasu , Selvaraj T. , Jeswanth S , Devakumar Murugesan Satish
Published: December 2023

Background : Chronic calcic pancreatitis is a debilitating disease which signicantly affects the quality of life of patients in the form of loss of
work days, repeated hospital admissions etc. They need high analgesic requirement also. Traditionally these patients were rst managed with
medical management and surgery was advocated later in the course of disease. To assess the improvement in quality of life Objective of Study :
and symptomatology in patients who had surgical intervention in the form of LPJ or Frey's procedure for chronic calcic pancreatitis Methods:
Data of last 92 patients, who underwent LPJ or Frey's procedure for CCP during the period of January 2020 to June 2022, in our department was
analysed retrospectively using QOL questionnaire (EORTC and customised) and VAS scores during the month of september 2023. Data was
compiled and analysed Follow up period in our study ranges from 15 to 45 months. On stati Results. stical analysis 90 % of the patient showed long
lasting pain relief and satisfaction with surgery. More than 90 % showed improvement in Quality of life in the form of going for work, leading
normal life and supporting family. Only a minority (8 %)of patient had recurrent symptoms and need either medical or surgical interventions. 5%
of patient showed features of endocrine and exocrine insufciency. This results were statistically signicant (p- value 0.5). The satisfaction and
improvement were more marked in patients who underwent surgical intervention early (less than 1 yr) in the course of disease and those who have
dilated ductal system secondary to intraductal stones or strictures surgica Conclusions : l intervention ,especially early in the course of disease will
lead to high patient satisfaction, signicant improvement in pain scores and quality of life
DIAGNOSTIC EVALUATION OF UNEXPLAINED INFERTILE WOMEN FOR CHRONIC ENDOMETRITIS BY ENDOMETRIAL HISTOPATHOLOGY AND IMMUNOHISTOCHEMISTRY
Authors: Das Mahua , Rashmi Rashmi , Gogoi Priyanka , Pal Singh Narendra
Published: December 2023

Introduction: Wide variety of unexplained infertility is due to Chronic Endometritis(10-66%). Diagnosis is based on detection of plasma cell
inltration in the endometrial stroma on histopathology. IHC staining for CD 138 improves the sensitivity. Objective: Percentage of chronic
endometritis among Indian unexplained infertility by endometrial histopathology and immunohistochemistry. Methods: A total of 75 study
subjects were enrolled in the study. Endometrial biopsy was taken in late follicular phase. The biopsy tissue was sent for histopathological
examination for detection of plasma cells, for common bacterial cultures and for GeneXpert for detection of endometrial tuberculosis. The patients
diagnosed with chronic endometritis were given antibiotic treatment according to the microbial cultures. Results: 12.2% cases (9/75) of
unexplained infertility were diagnosed as chronic endometritis out of which 2 cases were diagnosed by routine histopathology and additional 7
cases were diagnosed by immunohistochemistry CD138. Detection by IHC CD138 was found to be much higher than routine HPE and the
difference was statistically signicant (12.2% versus 2.7%, p value = 0.008). Endometrial culture was positive in all CE patients showing growth of
common organisms who received antibiotics according to the culture. One patient was diagnosed with TB endometritis. Conclusions:We detected
chronic endometritis on endometrial biopsy in 12.2% of the unexplained infertility cases in Indian population. Immunohistochemistry for CD138
was found to be much superior to routine histopathology in diagnosing chronic endometritis. Tubercular endometritis was detected in only one case
(1.3%) in our study population.
LAPAROSCOPIC MANAGEMENT OF ADNEXAL MASSES -A DESCRIPTIVE STUDY FROM A TERTIARY REFERRAL CENTER
Authors: N S Shubhashri , Kishore S V Kapil , A G Rashmi , B Srilakshmi.
Published: December 2023

Adnexal masses are fairly common among women with a prevalence of 0.17% to 5.9% in asymptomatic women and 7.1% to 12% in symptomatic
women of all age groups but very common among reproductive age. These masses can be of gynecological or non-gynaecological origin & can be
benign, malignant or borderline masses. Laparoscopic management of adnexal masses is considered to be standard of care in management of
benign adnexal masses. The present study aims to evaluate the effectiveness & safety of laparoscopic management of adnexal masses thought to be
benign preoperatively along & also assess their clinical outcomes.
GeoValueIndex map of public property assets generating via Analytic Hierarchy Process and Geographic Information System for Mass Appraisal
Authors: Unel Fatma Bunyan , Kusak Lutfiye , Yakar Murat
Published: December 2023

The aim of this study is to develop a value-based GeoValueIndex with AHP weights and GIS for the criteria of the Mersin University (MEU) Çiftlikköy Campus real properties, and it is referred to as the “GeoValueIndex” in this study. GeoValueIndex is a symbolic value that combines geographic and non-geographic features of real properties. The data of the real properties on the campus were collected and arranged for mass appraisal. One of the Multi Criteria Decision Analysis (MCDA) methodologies, Analytic Hierarchy Process (AHP), was used to weight the criteria. GeoValueIndex was calculated by multiplying each parcel’s geographic and non-geographic data by their weights and adding them. GeoValueIndex Map is obtained by associating GeoValueIndex and parcel in GIS software. GeoValueIndex of real properties save time, effort, and cost in mass appraisal processes. There are many techniques for doing GeoValueIndex operations, and the ones presented in this study are only proposals.
Rassegna giurisprudenziale I semestre 2023
Authors: Lucifero Nicola
Published: December 2023

Rassegna giurisprudenziale
Does Curriculum Fail Indigenous Political Aspirations? Sovereignty and Australian History and Social Studies Curriculum
Authors: Keynes Mati , Marsden Beth , Thomas Archie
Published: December 2023

Through analysis of curricular materials (syllabus documents and supplementary readers) from the late-nineteenth century to the present, this article explores the role of school curriculum in shaping understandings of Indigenous political aspirations in the Australian context. It juxtaposes curricular materials with significant occasions of Indigenous political activism in Australia since the late-nineteenth century: the Coranderrk campaign of the 1870-80s, the Wave Hill Walk Off in 1966, the establishment of the Aboriginal Tent Embassy in 1972, and the Bicentenary protests of 1988. From this analysis, five narrative sub-themes were developed—Invisibility, Benevolence, Obfuscation, Innocence, and Acknowledgement—which captured the ways that Indigenous sovereignty, nationhood, and political legitimacy had been represented. In drawing out some continuities and changes to curricular representations of First Nations’ and settler sovereignty, nationhood, and political legitimacy over a one hundred year period, this article highlights the uneven ways that curriculum has, and continues to, represent political possibilities on the Australian continent. This article offers insights for Nordic contexts where there are also contests about legacies of colonialism in the public sphere, including in education.
Medication Compliance in Type 2 Diabetes Patients: HbA1c and Lipid Profile at Aulia Jombang Clinic 2020
Authors: Pratama A. Ronald , Laksmana Putra Cahya Yudha , Budiarti Retno , Putra Oki Nugraha , Kresnamurti Angelica , Sulistiawati Sulistiawati
Published: December 2023

Diabetes Mellitus (DM) is a chronic metabolic disease characterized by high blood sugar levels due to insulin secretion or work defects. Poor treatment adherence leads to uncontrolled glycemic levels and complications. Therefore, ensuring patient adherence to therapy and reducing HbA1c and lipid profiles is essential. This research employs an observational, cross-sectional design, using non-probability purposive sampling to select 55 respondents via the Slovin formula. The study examines medication adherence as the independent variable, Hba1c levels, and lipid profile as the dependent variables. Data analysis involves SPSS, utilizing univariate and bivariate methods for ordinal and nominal scales. MMAS-8 questionnaire assesses the knowledge, while data comes from questionnaires and medical records of type 2 DM patients at Aulia Jombang Clinic. Study findings showed notable adherence to treatment, with 38 respondents (60.9%) complying and 17 (30.1%) not. Chi-square tests yielded significance, p values: HbA1c 0.012, LDL 0.035, total cholesterol 0.008, triacylglycerides 0.011, and HDL 0.002, based on MMAS-8 questionnaire data. In conclusion, the results indicate statistical significance (p-value < 0,05), so there is a positive correlation coefficient, indicating that higher levels of treatment adherence are associated with more optimal HbA1c control and lipid profiles.
Cirurgia de Ressecção Pulmonar em Pacientes com Câncer de Pulmão: Revisão Abrangente de Resultados Clínicos
Authors: Belchior de Souza Schiavinatto Beatriz , Bresciani Rossi Gustavo , Cavalcante Zenni Maria Fernanda , Valentini Boscardin de Oliveira Fernanda , Santos Fonseca Lara , Correa Meyer Liotti Marina , Favali Rodrigues Menke Isabela , Gomes Hespanha Junior Nelson , Queiroz Oliveira Ariella , Ferreira Rhinow Michels Lais , Valentini Boscardin Luca
Published: December 2023

Este artigo científico aborda a relevância e os resultados clínicos associados à cirurgia de ressecção pulmonar em pacientes diagnosticados com câncer de pulmão. A cirurgia de ressecção pulmonar desempenha um papel crucial no tratamento, sendo uma estratégia fundamental para a remoção eficaz do tumor. Diferentes tipos de ressecção, como lobectomia e pneumonectomia, são explorados, destacando indicações específicas para cada procedimento e suas implicações na qualidade de vida pós-operatória dos pacientes.

O estudo realiza uma análise abrangente dos resultados clínicos obtidos a partir da cirurgia de ressecção pulmonar. São examinados desfechos como sobrevida global, recorrência tumoral e complicações pós-operatórias, utilizando dados provenientes de estudos clínicos, ensaios randomizados e coortes retrospectivas. Essa revisão proporciona uma visão aprofundada da eficácia e segurança dessa intervenção cirúrgica.

Além disso, discute-se fatores prognósticos que impactam os resultados da cirurgia, considerando elementos como o estágio da doença, o status funcional pulmonar e a presença de comorbidades. Essa análise refinada permite uma compreensão mais aprofundada dos subgrupos de pacientes que podem se beneficiar mais da ressecção pulmonar no contexto do câncer de pulmão.

Por fim, destaca-se as implicações práticas dos resultados apresentados, sugerindo diretrizes para a tomada de decisões clínicas e delineando possíveis áreas para pesquisas futuras. O objetivo é fornecer uma base sólida para a melhoria contínua da prática clínica, contribuindo para o avanço no tratamento cirúrgico de pacientes com câncer de pulmão.
MELANOMA: UMA ANÁLISE ABRANGENTE
Authors: Barcala Natália da Silva , Narracci Felipe , Perillo Gabriel Martins , Corredato Júlia Cauneto Banheti , Fonsatti Lilian Mariano , Sampaio Francielli Elaine de Araújo , Bueno Lorraine da Rosa , Britto Luiz Eduardo Gomes de , Castilhos Ana Laura Macias , Domingues Sabrina Picin , Ataides Ágatha Ianka da Silva , Nascimento Bianca Vilela , Rodrigues Vitória Mendonça , Péres Júnior Ronaldo Rogério , Paulik Kamilla Ferreira , Coelho Ana Julia Koehler Guedes
Published: December 2023

O melanoma é uma neoplasia cutânea maligna originada nos melanócitos, células responsáveis pela produção de melanina. Este tipo de câncer de pele tem a capacidade de se disseminar rapidamente para outros órgãos, o que pode resultar em complicações sérias. A dermatoscopia, biópsia cutânea e tomografia por emissão de pósitrons são técnicas essenciais para o diagnóstico precoce e estadiamento do melanoma.  O tratamento do melanoma envolve uma abordagem multidisciplinar, incorporando cirurgia, imunoterapia, terapia-alvo e radioterapia, conforme a extensão da doença. Avanços notáveis incluem inibidores de checkpoint imunológico, como ipilimumabe e pembrolizumabe, que demonstraram eficácia significativa em melanomas avançados. A prevenção do melanoma é fundamentada na conscientização sobre fatores de risco, como exposição excessiva ao sol, e programas de rastreamento dermatológico em populações de alto risco. A compreensão molecular do melanoma, incluindo mutações em genes como BRAF, tem contribuído para estratégias de tratamento mais personalizadas.  Em suma, o melanoma representa um desafio clínico significativo, exigindo uma abordagem integrada que abrange desde técnicas diagnósticas avançadas até terapias inovadoras, com ênfase na prevenção e conscientização.
Práticas Pedagógicas com Ensino Híbrido - o que dizem as pesquisas?
Authors: Santos Cíntia Velasco
Published: December 2023

Este artigo propôs discutir potencialidades e limites do Ensino Híbrido, na educação pública básica brasileira, a partir de pesquisas de mestrado e doutorado sobre o tema. A análise qualitativa, de abordagem bibliográfica, apresentou alguns possíveis sentidos para as tecnologias educacionais digitais e aspectos das práticas pedagógicas permeadas por elas, analisando, especificamente, o Ensino Híbrido. A partir do aporte teórico de Horn, Staker e Chirstensen, abarcado pelas pesquisas analisadas, o estudo identificou que essa modalidade de ensino pode se apresentar como articulação entre o tradicional e o inovador – com suporte das tecnologias – e, por vezes, como solução educacional. Entretanto, suas potencialidades podem encontrar limitações na realidade das escolas públicas, onde há desigualdades de acesso e de letramento digital.
La planeación didáctica para la enseñanza en línea
Authors: San Vicente Parada Aida Del Carmen
Published: December 2023

El artículo tiene como cometido establecer los elementos de la planeación didáctica. Ello implica la selección y organización de contenidos, situaciones y ambientes de aprendizaje y elaboración de material didáctico por parte del profesor, con el fin de obtener aprendizaje significativo en ambientes a distancia, que permita al alumno aplicar la teoría en la práctica desde una postura crítica. Para lograr lo anterior es necesario integrar recursos virtuales como: foros, sopas de letras, debates, blogs, wikis, documentales, juegos, líneas del tiempo, historietas, mapas conceptuales, carteles. El trabajo comienza con el marco conceptual de la didáctica, y las etapas de la planeación didáctica, para culminar con la descripción de los recursos virtuales que permiten cumplir con los objetivos de aprendizaje. El trabajo es un informe de experiencia, que propone herramientas para la autogestión del conocimiento en la enseñanza en línea.
O paradigma da Complexidade e a sua aplicação na Educação: reflexões sobre a prática docente
Authors: De Oliveira Mateus Esteves , Pinto Adriana Alves , Kakpo Arcade Johannes
Published: December 2023

Este artigo apresenta reflexões de três pesquisadores que se dedicam ao estudo das teorias que compõem o paradigma da Complexidade nos contextos de ensino e de aprendizagem. O objetivo foi facilitar o entendimento de estudantes, professores e pesquisadores iniciantes no estudo da Complexidade com seus desdobramentos no campo da Educação. Para isso, este trabalho abordou a Complexidade como um conjunto de teorias já consolidadas na academia, como por exemplo, a Teoria Geral dos Sistemas (TGS), a Teoria do Caos e a Geometria Fractal. O ponto em comum entre elas é o destaque que conferem ao fator “interação” entre os componentes de um determinado sistema, como a escola, e à autossimilaridade, que possibilita certa previsibilidade de fenômenos aleatórios. Foi possível observar que as propriedades características das abordagens complexas são fundamentais para a compreensão das relações inerentes à prática docente.
The Farey Sum of Pythagorean and Eisenstein Triples
Authors: CRASMAREANU Mircea
Published: December 2023

A composition law, inspired by the Farey addition, is introduced on the set of Pythagorean triples. We study some of its properties as well as two symmetric matrices naturally associated to a given Pythagorean triple. Several examples are discussed, some of them involving the degenerated Pythagorean triple $(1, 0, 1)$. The case of Eisenstein triples is also presented.
El impacto del empoderamiento de las mujeres en la nutrición infantil en Guatemala
Authors: Jerez Sarceño Catheryne , Bonilla-Anariba Sara , Sanders Arie
Published: December 2023

Guatemala tiene una de las tasas de retraso en el crecimiento más altas del mundo, y la población indígena es la más afectada. La condición de la mujer es uno de los factores determinantes más importantes en la nutrición infantil porque de ella depende la calidad del cuidado de los niños, lo que afecta directamente a su estado nutricional. En consecuencia, la condición de la mujer es un factor importante en los esfuerzos nacionales por combatir la malnutrición. El presente estudio se propuso comprobar si existía una relación entre el empoderamiento de la mujer y el estado nutricional de los niños en Guatemala. Este estudio utilizó datos de la Encuesta Nacional de Salud Materno Infantil 2014-2015, con variables de respuesta basadas en los estándares de la Organización Mundial de la Salud. Se descubrió que el empoderamiento de la mujer estaba positivamente relacionado con el estado nutricional infantil, mientras que la pertenencia étnica estaba negativamente relacionada. En consecuencia, la condición de la mujer es un componente importante en la lucha nacional contra la malnutrición, pero debe abordarse y diferenciarse en función del contexto cultural.
Espiritualidad y felicidad en líderes jóvenes y adultos de comunidades religiosas
Authors: Aucapuri Yucra Angela
Published: December 2023

Se investigó la relación entre las facetas de espiritualidad y felicidad en una muestra proporcional compuesta por 487 líderes de cuatro comunidades religiosas, con un tiempo de participación de 1 a 57 años: Adventista, Católica, Evangélica y la Iglesia de Jesucristo de los Santos de los Últimos días. Los miembros de comunidades religiosas, completaron la escala de Espiritualidad, Religiosidad y Creencias Personales de World Health Organization, (SRPB) (WHOQOL-BREF), la Escala de Felicidad (EFL) y una ficha demográfica. La espiritualidad predijo mejores niveles de felicidad, en adultez media y tardía, las facetas de espiritualidad de mayor predominancia son la fortaleza espiritual y el significado y objetivo de la vida. Ambas evidenciadas en el apoyo emocional y social a través de la vida integrada en comunidad.
Creation of Universal Application and Project Management in Georgian Companies
Authors: Ana Gegeshidze Ana Gegeshidze
Published: December 2023

Developing an universal concept is a creative process. Their effective production is related to the development of production. Studying the concepts of development of well-known leading Georgian companies, both large and medium production, clearly indicates that the competitive advantages they use, are individual. The fundamental points must first be reflected in the universal and original adaptive system of company management proposed by the enterprise.
Each new universal concept must correctly reflect the core values of the brand. The universal concept is designed to connect the important problems of enterprise company management, all constituent components and provide a common focus on brand identity. This universal concept is also used by Georgian companies.
After the completion of the project development and implementation stages in Georgian companies, the developer carries out a full audit of the enterprise's activities. The development of goods and services is one of the main points of the universal concept. Georgian companies with successful brands are constantly improving their products and services. This process takes many forms, both improving the product itself and accompanying services.
Therefore, an important problem of company management is related to the adaptive system of correct management of the company. A universal concept will be created when the development of an innovative product begins, based on the creation of new ideas and concepts. The universal concept of product development is multifaceted and complex; And the closer the competing firms' products are, the more important it is to consider the entire range of values.
Keywords: Concept; Value; Integration; Management; Development.
The Importance of Quality Management System and The Ways to Increase Its Awareness in Georgia (on the example of neighboring countries)
Authors: Ekaterine Aghamanashvili Ekaterine Aghamanashvili
Published: December 2023

In today's business environment, high quality products and services are vital for organizations to survive and maintain competitive advantage. Implementation of quality management system is still a challenge for Georgian entrepreneurs. According to the data of the National Statistics Service of Georgia on 31.12.2021, there are 183,300 operating organizations registered in Georgia, and only 176 organizations are certified by the ISO 9001 standard, i.e. approx. 0.1% (ISO Survey, 2021), which shows that awareness of the importance of the quality management system is extremely low in our country. Georgian entrepreneurs are less informed about the requirements needed to enter export markets, among which one of the most important requirements is quality assurance. The paper aims to review the existing experience in the direction of measures supporting the awareness of the quality management system of the business sphere of Azerbaijan and Russia and to develop specific recommendations based on their analysis, taking into account the reality of Georgia.
Keywords: Quality management, principles of quality management, quality management system awareness, ISO 9000 series standards.
Pengaruh Modal Kerja Terhadap Profitabilitas Perusahaan Manufaktur Sektor Makanan Dan Minuman Yang Terdaftar Di Bursa Efek Indonesia Tahun 2018 – 2021
Authors: Ginting Mitha Christina , Simanjuntak Arthur , Siahaan Septoni B , Sitorus Enjelina Patrisya Uli Br
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh modal kerja terhadap tingkat profitabilitas pada perusahaan manufaktur sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2018 - 2021. Variabel dalam penelitian ini meliputi Perputaran Kas (X1), Perputaran Piutang (X2), Perputaran Persediaan (X3) dan Profitabilitas (Y). Penelitian ini menggunakan jenis penelitian verifikaktif dengan metode Explanatory Survey, yaitu metode yang digunakan dalam pengambilan sampel yaitu dengan purposive sampling. Hasil penelitian secara parsial, Ada pengaruh positif tidak signifikan Perputaran Kas terhadap Porfitabilitas, Ada pengaruh positif signifikan Perputaran Piutang terhadap Profitabilitas, Ada pengaruh positif tidak signifikan Perputaran Persediaan terhadap Profitabilitas. Sedangkan hasil secara simultan Perputaran Kas, Perputaran Piutang, dan Perputaran Persediaan berpengaruh signifikan terhadapat Profitabilitas
Assessment of physical functioning in rheumatoid arthritis patients after rituximab therapy using health assessment questionnaire-disability index
Authors: Anna Maria Joy , Shaji Akshara , Mathew Shaniya , Abraham Suja
Published: December 2023

The most frequently used instrument for measuring self-reported physical function in rheumatoid arthritis is the health assessment questionnaire – disability index. The objective of this study was to assess the effects of treatment with rituximab on patient-reported outcomes in severe rheumatoid arthritis patients. Rituximab was initiated in RA-diagnosed patients who experienced treatment failure or decreased response on the administration of conventional disease-modifying anti-rheumatic drugs. Treatment response after 1g of rituximab infusion was assessed at <6 months and > 6 months follow-up period using patient-reported outcome measure tools and laboratory investigations. Functional ability was evaluated using a questionnaire and the overall disability index was calculated. It was found that all patients achieved minimum clinically important difference(>0.2) from baseline HAQ value within 6 months of rituximab. Assessment of the functional ability demonstrated that the majority of the patients experienced significant improvement in all domains of HAQ-DI after rituximab administration. Patient global assessment shared a moderate correlation with almost all domains of HAQ-DI. Physical function as measured by HAQ-DI  showed clinically meaningful improvement within 1 year of rituximab therapy. It has proven to be a safer and more effective treatment option when compared to conventional disease-modifying antirheumatic drugs and has also helped in achieving better responses at a faster pace.
Comparative Insilico Docking Study Involving Antagonistic Activity of CoumarinDerivatives on EGFR and CDK2
Authors: Thomas Riya Ann , Sunil Eva Sara , Fernandez Anna Abel , Anil Soorya , Antony Anjana , Davis Ann Maria , Thomas Godwin , T S Saranya , Sreeram Greeshma , Abraham P Elizabeth
Published: December 2023

Epidemiological evidence suggests that about 25% of cancer occurs due to chronic inflammation, thus it is clear that cancer and inflammation are related. Piroxicam is the one of the drug that is used in the treatment of both cancer and inflammation, but it is having some side effects like constipation, blurring of vision ,skin rashes etc. Coumarin is having both anti-inflammatory and anti-cancer activity so the purpose of this study is to screen the best target among EGFR and CDK2. Docking analysis was carried out using AutoDock4.  From the study it was found that EGFR showed better result compare to CDK2. Also methyl substitution at 8th position and chlorine substitution at 5th position of coumarin showed better activity than standard drug piroxicam and phytoconsitutents isofraxidin  andscopoletin.
Formulation and evaluation of herbal aftershave gel
Authors: Francis Celu Mariya , George Riya , Sankar Anaswara , J Ancy I , Mathews Manju Maria , R Badmanaban
Published: December 2023

Aftershave gels are cosmetic products that may often contain alcohol which is an antiseptic agent to prevent infection of cuts, as well as to act as an astringent to reduce skin irritation. However, alcohol-based aftershave gels may be prone to cause burns or irritations. The main aim of the present study is to formulate and evaluate aftershave gel with reduced alcohol content using Hemigraphis colorata extract. The Hemigraphis colorata plant possesses wound healing and anti-inflammatory actions. Ethanol was used as solvent for the extraction in our present study.  The gel formulation F0 was made according to the conventional formula having 50% alcohol content. The second formulation F1 was the one that contains three fourth of the alcohol of the above formulation. The final gel F2 was the one with three-fourths of the quantity of alcohol mentioned in the conventional formula and having Hemigraphis colorata extract in the concentration 50mg/ml. Gels were evaluated for pH, viscosity, and anti-bacterial properties. From the studies conducted it was concluded that the formulation used Hemigraphis colorata extracts showed better antimicrobial activity than the conventional “alcohol-only” formulation. So, from the study it can be concluded that plant would be a promising candidate to be used in an aftershave preparation, provided it exhibits astringent activity also.
Cosmetic use related adverse events and need for cosmetovigilance
Authors: Joseph Merrin , Shaji Karishma , T M Mahin , P B Nandana , Das Krishna
Published: December 2023

Cosmetics are applied to human body for cleansing, beautifying, promoting attractiveness or altering appearance. Cosmetics are causing adverse events to users, yet evidence about its magnitude is limited among students due self-diagnosis and self-medication .To know about the cosmetic use related adverse events and to enhance awareness regarding cosmetovigilance among the students of Nirmala College of pharmacy, Muvattupuzha by an educational intervention. To assess the prevalence of cosmetics, use among the students of Nirmala college of pharmacy, Muvattupuzha.To identify the cosmetics related adverse events and knowledge , To improve the awareness regarding cosmetovigilance. By online survey using google form. The questionnaire consisted of three parts, demographic profile, utilization pattern, participant's experience of cosmetics-related adverse reactions for the last two years.an awareness program about cosmetovigilance system.  Access the knowledge of students one month after awareness.502 participants,55.2% with pimple ,55.2% with hair loss,41.4% with allergic reaction, dryness of skin, etc.
Formulation and evaluation of preungual delivery system containing eugenol for the treatment of onychomycosis
Authors: Elias Mini , Mathew Flowerlet , T Gourisree , Rajan Anila , Davis Ashly
Published: December 2023

The purpose of the study was to formulate a Preungual delivery system containing Eugenol for the treatment of Onychomycosis. And to find out the best polymer concentration, concentration of penetration enhancers and to carry out the anti-fungal testing on the best formulation obtained. The in vitro diffusion studies were carried out in Franz diffusion cell using phosphate buffer pH 7.4 and methanol as medium, whereas the permeation studies were carried out using hooves membrane. The percentage of cumulative drug released was determined by a UV spectrophotometer. The formulation containing 10% w/v of ethyl cellulose along with 2.5%w/v thioglycolic acid and 2.5 %v/v of dimethyl sulfoxide showed a good release. Eugenol nail lacquer's sensitivity against Candida albicans was determined by measuring the zone of inhibition by comparing it with a standard drug. The formulation showed a zero-order release pattern and the Higuchi model for the mechanism of release.
Formulation and evaluation of controlled porosity oral osmotic pump tablets of furosemide
Authors: Thekkal Teena Chackochen , Renju Reba , Mathews Manju Maria , R Badmanaban
Published: December 2023

Oedema is an abnormal accumulation of fluid in the interstitium located beneath the skin and in the cavities of the body which can cause severe pain. Furosemide has been shown to be effective and safe in patients with hypertension and/ or coronary heart disease. Osmotic pump tablets deliver the drug in an optimized manner to maintain drug concentration within the therapeutic window and minimize toxic effects. The major objective of the study was to prepare and evaluate oral controlled porosity osmotic pump tablets of furosemide, to reduce the dosing frequency and thereby side effects, and to release the drug for a prolonged period in a controlled manner that is independent of pH and hydrodynamic activity. Pre-formulation studies and pre-compression parameters of tablet blends of osmotic pump tablets of furosemide were carried out. Oral-controlled porosity osmotic pump tablets of furosemide were prepared and subjected to different evaluation tests. Precompression parameters indicated that granules have a good flow property. All the formulations showed good mechanical strength. All the nine formulations showed a drug release of more than 60% in the 12th hour. Optimised formulation showed a drug release of 99.21% in 12th hr. Stability studies conducted indicate that the product is stable.
TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI RSUD UMAR MAS’UD BAWEAN
Authors: Salniyah  , Nurul Faizah  , Amrina Amalia Yogananda
Published: December 2023

RSUD Umar Mas’ud Bawean merupakan salah satu rumah sakit pilihan masyarakat Bawean untuk berobat. Pelayanan kefarmasian merupakan bagian yang tidak terpisahkan dari sistem pelayanan kesehatan yang berperan penting dalam meningkatkan mutu kehidupan pasien. Penelitian ini bertujuan untuk mengetahui karakteristik responden di RSUD Umar Mas’ud Bawean, gambaran pelayanan kefarmasian di RSUD Umar Mas’ud Bawean, dan tingkat kepuasan pasien terhadap pelayanan kefarmasian di RSUD Umar Mas’ud Bawean. Penelitian ini termasuk penelitian non eksperimental dengan analisis kuantitatif menggunakan model SERVQUAL dengan perhitungan CSI (Customer Satisfaction Index) dan menggunakan skala likert dengan lima dimensi yaitu reliability, responsiveness, assurance, empathy dan tangible.

Hasil penelitian karakteristik responden, menunjukkan bahwa jenis kelamin yang paling banyak adalah wanita (76%), usia terbanyak 15-24 tahun (42%), tingkat pendidikan tertinggi adalah tamatan SMA (43%), dan pekerjaan terbanyak adalah ibu rumah tangga (32%). Gambaran pelayanan kefarmasian di RSUD Umar Mas’ud Bawean pada dimensi reliability cukup puas 2,6%, puas 55,4%, dan sangat puas 42%. Pada dimensi responsiveness cukup puas 3%, puas 49,25%, dan sangat puas 47,75%. Pada dimensi assurance tidak puas 0,2%, cukup puas 1,4%, puas 50,2%, dan sangat puas 48,2%. Pada dimensi empathy tidak puas 0,2%, cukup puas 1,6%, puas 47,8%, dan sangat puas 50,4%. Pada dimensi tangibles cukup puas 3,5%, puas 45,6%, dan sangat puas 51,2%.

Hasil skor kepuasan pasien dengan perhitungan CSI (Customer Satisfaction Index) sebesar 89,68 yang berarti pasien merasa sangat puas terhadap pelayanan kefarmasian di RSUD Umar Mas’ud Bawean.