bluuebunny/crossref_metadata_2025 huggingface dataset:
Strengthening local communities through development of local self-government institutions
Authors:   independent researcher, PILSHCHIKOV ANTON
Published: November 2021

Solving problems at the local level requires the unified activity of both the municipal authorities and representatives of civil society. In this regard, the author attempts to comprehend the concepts of ‘local self-government’ and ‘local community’ in the context of the formation of a cooperative environment in the relationship between them, and also gives his own definition of the term based on existing approaches and views. The essence of this understanding of the local community is to emphasize the uniqueness of the role of local governments and public organizations, as well as individual citizens. The author focuses on the participation of non-profit organizations in this process, which is illustrated by the example of the all-Russian Council of local self-government and projects implemented by this organization, as well as by considering the work of the Association for the promotion of twinning relations of Cologne and Volgograd. The paper concludes that the role of the non-profit sector in the development of local communities needs to be strengthened in Russia. At the same time, it is necessary to change approaches to the definition of the term ‘local community’ in such a way that it reflects the desire to form associations that meet the criteria for involvement in the process of solving local problems that arise for public organizations and local residents (of different focus and different significance for the municipal territory). It is important that local communities have their own opportunities for self-identification against the background of existing associations and have a fruitful influence on the communication process between different communities and allow the exchange of experience in various fields.
Innovations in legal regulation of the state civil service of the Lipetsk region
Authors:   Administration of the Lipetsk region, GONCHAROVA ELENA
Published: November 2021

The legal aspects of implementating personnel policy are an integral part of the successful work for the regional administration. The article examines the legal mechanisms used by the state civil service of the Lipetsk region administration, aimed at forming a model of qualification requirements to fill positions in civil service and developing the system for material and non-material motivation, increasing efficiency in state-service relations. Currently, to reform and improve the effectiveness of the state civil service, we need to create a flexible system of incentives for employees; since the effectiveness of their activities largely depends on their personal interest in the performance of official duties at a high level. The Lipetsk region administration monitors the regulatory legal framework on civil service in real-time. This method of quality control contributes to the improvement of personnel policy, standardization of personnel processes, and their uniform application in all governmental bodies of the region.
Participatory strategizing: engagement that delivers results
Authors:   Russian Presidential Academy of National Economy and Public Administration, GRACHEVA IRINA
Published: November 2021

The article is devoted to the changes in modern public administration associated with the turn of public management towards customer focus. It is noted that the implementation of this approach will inevitably raise the question of the degree of citizen engagement in the creation of the final design service. The author considers the active involvement of all stakeholders, including research scientists, in the development of these programs to be one of the ways to ensure the population’s loyalty to the actions of the state. The author refers to the experience of experts of the Higher School of Public Administration of the Russian Presidential Academy of National Economy and Public Administration participating in the development of strategies for various territories and sectors of government as well as individual departments in the period from 2016 until present. Additionally, a new approach for organizing group work of stakeholders, which combines all the successful developments connected during the experimentation phase into a single whole, is proposed. This approach is called “Participatory Strategizing and Design”. The approach is based on creating an empathy effect among stakeholders via actions to organize interactions with them. It is emphasized that the change in expectations proposed by this approach can significantly increase the efficiency of projects: considering strategizing as a process, and not as a result, releases significant energy and contributes to the adoption of extraordinary creative decisions.
Demographic development of Russian regions with a focus on the Republic of Mordovia against the background of COVID-19 pandemic statistics
Authors:   Ogarev Mordovia State University, LOGINOVA NINA , SEMINA IRINA ,   Ogarev Mordovia State University, PERETOCHENKOVA OLGA ,   Ogarev Mordovia State University
Published: November 2021

The article analyzes the conditions that ensure a favorable demographic situation, personal and family development in the regions of Russia. In 2020-2021, against the background of COVID-19 statistics, a decline in reproduction rates, a sharp increase in mortality rate, as well as a reduction in life expectancy and the total population is clearly visible. The author pays special attention to the title of the textbook, an indication of the state affiliation and peculiarities of Russian government: with the invariability and independence of administrative laws from state and nationality, the importance of understanding and taking into account the specifics of a particular country to ensure the effective development of its socio-economic system is emphasized. The author highlights the advantages of the peer- reviewed publication over other similar publications, which are the close attention to human resource management, as well as the combination of theoretical and practical material. The implementation of regional population policies should reach a new level since they should contribute to improving the level and quality of life of people and strengthening the institution of the family.
Calling for Zoe as a Utopian Gesture
Authors: Annette Arlander
Published: November 2021

This exposition discusses the possibility of embracing an expanded notion of life, a zoe-centred egalitarianism, as proposed by Rosi Braidotti, in order to envision a liveable future on the planet and the utopian potential in the act of calling for an imaginary creature, a dragon, using as examples some video works created in 2012-2013 and retuned to in 2019.
SOSIAALISEN SOMATIIKAN UTOPIA: Ruumiin orientaatio tilassa
Authors: Ilmari K.
Published: November 2021

Somatiikka kehittää kykyä tunnistaa totunnaisia liikkumisen tapoja, ja mahdollisuutta murtautua kohti uusia liikemuotoja. Aistiva tutkimus mahdollistaa uudenlaisia yhteyksiä kehon käyttöön sosiaalisen tilan tutkimuksessa.Kutsun ruumiinsosiologian teoriasta ammennettuja harjoituksia sosiaaliseksi somatiikaksi seuraten tutkija Jill Greeniä (2015). Sosiaalisen somatiikan keskeinen kohde on yhteiskunnan säätämät ruumiilliset sijoittumiset tilaan ja somaattisia harjoitusmuodot, jotka kasvattavat kehon sosiaaliseen tiedostamiseen.

Kehon pienistä eleistä ja kokemuksesta nouseva muutos voidaan nähdä sosiaalisen tai poliittisen muutoksen mahdollistajana (Manning 2016; Kortelainen 2020). Tarkastelen artikkelissani tätä kehotietoisuudesta nousevaa, ja jokaisen meidän kehoon kytkeytyvää mahdollisuutta sosiaaliselle muutokselle. Sosiaalisen muutoksen kohteena kulttuurisesti luodut kehon kuvat vaikuttavat merkittävästi ihmisten jokapäiväiseen elämään yhteiskunnassa.

Sara Ahmedin queer fenomenologian tapaan tarkastelen, kuinka kehon tilallisuus ja kehon suhde objekteihin ja esineisiin vaikuttaa korporeaalisella tasolla siihen, mitä keholta odotetaan.
On the Potential of Exercises in Live Art Pedagogy
Authors: Kristina Junttila
Published: November 2021

This exposition is a web of exercises which have been part of different participatory performances, -installations and -workshops. The projects were undertaken during the years of 2014–2019 and are part of my artistic pedagogical research about the potential of exercises in live art. By extricating exercises from their original context and placing them in a rhizomatic map alongside other exercises, I want to examine exercises as an important tool in creating the future of live art and new realities. A tool that can be used to create new performance art works and imagining the future. The exercises in live art pedagogy has potentials in imagining and creating new realities. Each exercise can also have value as an artwork in themselves, as a performance event score.

The exercises in this exposition can be looked upon as traces of earlier works, and by cross-contextualising the exercises I look for how they are interrelated and what the materiality or technique of an exercise can be. In this cross-contextualising I look for the agency of the different exercises. I have selected the active performative agents that best characterise fo the exercises. These are the formulation, objects, performer, audience, place, and time as such agents.
Effects of ABCB1 DNA methylation in donors on tacrolimus blood concentrations in recipients following liver transplantation.
Authors: Shi Chengcheng , Yan Liang , Gao Jie , Chen Shitong , Zhang Li-Rong
Published: November 2021

Aims: To investigate the effects of ABCB1 DNA methylation in donors on
individual differences in tacrolimus blood concentrations following
liver transplantation. Methods: Twenty-three donor liver samples
carrying the CYP3A5*3/*3 genotype were classified into two groups based
on the initial tacrolimus concentration/dose (C0/D) ratio following
liver transplantation. ABCB1 mRNA levels in liver tissues and HepG2
cells were determined by qRT-PCR. DNA methylation status in liver
tissues and HepG2 cells was determined using Illumina 850 methylation
chip sequencing technology and pyrosequencing. 5-Aza-2dC was used to
reverse methylation in HepG2 cells. Intracellular tacrolimus
concentrations were determined by liquid mass spectrometry. Results:
Genome-wide methylation sequencing and pyrosequencing analyses showed
that the methylation levels of three ABCB1 CpG sites (cg12501229,
cg00634941, and cg05496710) were significantly different between groups
with different tacrolimus C0/D ratios. ABCB1 mRNA expression in donor
livers was found to be positively correlated with tacrolimus C0/D ratio
(r = 0.458, P < 0.05). After treatment with 5-Aza-2-Dc, the
methylation levels of the ABCB1 CpG sites in HepG2 cells significantly
decreased, and this was confirmed by pyrosequencing; there was also a
significant increase in ABCB1 transcription, and this most likely
induced a decrease in intracellular tacrolimus concentrations.
Conclusions: ABCB1 CpG site methylation affects tacrolimus metabolism in
humans by regulating ABCB1 expression. Therefore, ABCB1 DNA methylation
in donor livers might be an important epigenetic factor that affects
tacrolimus blood concentrations following liver transplantation.
Ecological theory of mutualism: Robust patterns of stability and thresholds in two-species population models
Authors: Hale Kayla , Valdovinos Fernanda
Published: November 2021

Mutualisms are ubiquitous in nature, provide important ecosystem
services, and involve many species of interest for conservation.
Theoretical progress on the population dynamics of mutualistic
interactions, however, comparatively lagged behind that of trophic and
competitive interactions, leading to the impression that ecologists
still lack a generalized framework to investigate the population
dynamics of mutualisms. Yet, over the last 90 years, abundant
theoretical work has accumulated, ranging from abstract to detailed.
Here, we review and synthesize historical models of two-species
mutualisms. We find that population dynamics of mutualisms are
qualitatively robust across derivations, including levels of detail,
types of benefit, and inspiring systems. Specifically, mutualisms tend
to exhibit stable coexistence at high density and destabilizing
thresholds at low density. These dynamics emerge when benefits of
mutualism saturate, whether due to intrinsic or extrinsic
density-dependence in intraspecific processes, interspecific processes,
or both. We distinguish between thresholds resulting from Allee effects,
low partner density, and high partner density, and their mathematical
and conceptual causes. Our synthesis suggests that there exists a robust
population dynamic theory of mutualism that can make general
predictions.
The Role of Franjo Tuđman in the Process of Peaceful Reintegration of the Croatian Danube Region
Authors: Holjevac Tuković Ana
Published: November 2021

The role Franjo Tuđman and the Croatian government played in the process of peaceful reintegration of Croatian Danube region Hrvatsko Podunavlje (the Croatian Danube region) and in the establishment of the country’s full sovereignty is presented and analyzed, on the basis of documentary evidence, in this work. Also contained in this work are explanations and analyses related to the main objectives of the Republic of Croatia’s policies in the period from the end of 1995 to 1998. The influence of the USA and the international community on the process of resolving the conflict in the former Yugoslavia and their relationship with Franjo Tuđman is also presented. In this context this work gives an overview of the most relevant circumstances that led to the political agreement on peaceful reintegration of Hrvatsko Podunavlje and the two-year long implementation of the process.
Dr. Franjo Tuđman in School Textbooks
Authors: Artuković Mato
Published: November 2021

This paper analyses the way in which Dr Franjo Tuđman is depicted in the textbooks used in Croatian schools. The author concludes that while some basic biographical data are provided, with respect to his contribution as a statesman some authors are prone to politicization and even self-censorship, the intention of which is to diminish his contribution to the history of the Croatian people. Most issues concerning internal and external policies require further research.
Localization index of farms in the period 2008-2016 in the rural areas of the South Central Region
Authors:   Institute of Agricultural Economics - Sofia, Marinov Petar
Published: November 2021

The rural development policy in Bulgaria is dictated by the accompanying facts, with approximately 45% of the population living in them, covering 85% of the territory. The study and analysis of the socio-economic processes in agriculture of smaller administrative units of the NUTS classification gives an accurate picture of the real situation. The operation of farms ensures the production of different types of agricultural production. Contributing to the formation of Gross Domestic Product and the fulfillment of commitments in relation to the EU Common Agricultural Policy. The application of the localization index for agricultural holdings in the rural areas of the South-Central Region in Bulgaria reveals their real economic status. The study of the specialization factor for agricultural holdings covers an eight-year period 2008-2016. The localization index is the basis for an analysis of the different types of economic processes and phenomena. It is also applicable in smaller administrative areas, namely in the rural municipalities of the South-Central Region.
The role of small farms for sustainable rural development
Authors:   Institute of Agrarian Economics – Sofia, Fidanska Bojura , Koteva Nina ,   Institute of Agrarian Economics – Sofia
Published: November 2021

The study examines the role of small farms in the development of entrepreneurship and family business, which contribute to the sustainable development of rural areas in Bulgaria. The aim of the article is to outline the socio-economic importance of small farms on the sustainable development of rural areas, to reveal structural changes and to assess the impact of the implementation of the Common Agricultural Policy. The strengths of small farms for rural development and their needs are highlighted. The difficulties faced by producers in starting a family business are outlined. The results of the study clearly show that small farms are of great social, economic and environmental importance for rural areas. The lack of a definition of “family farm” in the national legislation hinders the process of integration of small farms in economic terms, which in turn affects the sustainability of rural areas. A preliminary assessment of the impact of the implementation of the Common Agricultural Policy on small farms has been made.
Agricultural risk management in small farms via innovations
Authors:   University of National and World Economy, Dimitrova Annie
Published: November 2021

Implementations of innovations in the agrarian sector would contribute to better risk management in the sector. Through the new achievements of science and the use of innovative methods and technologies, the stability of the sector can be increased as the farmer will be able to control the crisis processes and minimize unforeseen circumstances that can cause damage to the production in the farm. The purpose of the report is to identify and classify innovative practices and models to minimize the risk in the agrarian sector, particularly those suitable for small farms, and to summarize with the help of a survey of farmers' attitudes towards introducing innovations in their farms through which to limit the risk. The publication is based on the results of Project NI-16/2018 "Integrated approach to risk management in the agrarian sector" and is part of the dissemination of dissertation results in the field of innovation.
Opportunities for the development of small farms in Bulgaria
Authors:   University of National and World Economy, Harizanova-Bartos Hristina , Terziyska Ralitsa ,   University of National and World Economy
Published: November 2021

Small farms have an important place in the agricultural sector in Bulgaria. Their existence is essential for the development of agriculture in the country. The factors that have an impact on small farms can be derived as macroeconomic factors, demographic factors, agricultural policy, market factors and others. The influence of these factors also reveals a variety of opportunities for development, assuming that some farms will make efforts to increase their economic viability. The aim of the study is to analyze the opportunities for development of small farms in Bulgaria. To achieve this goal, the following tasks are set: 1) Review of theories on the prerequisites for the existence and development of small farms; 2) The role of small farms in Bulgarian agriculture; 3) Opportunities for development of small farms; 4) Main conclusions. The results presented in the publication are part of the project №15 / 8 of 2017. "Sustainable multifunctional rural areas: rethinking agricultural models and systems with increased requirements and limited resources", funded by the Scientific Research Fund.
The new risks of the agricultural treadmill and the inequality in the farmland size distribution in Bulgaria
Authors:   University of Economics - Varna, Georgieva Tanya
Published: November 2021

The purpose of this article is to examine the degree of realization of risk related to inequality in the distribution of the farmland size in Bulgaria. The study is based on Eurostat data for Bulgaria and other EU countries. The results show that specific indicators provide somewhat specific country characterizations.
Evaluation of а roject for building a house for rural tourism
Authors:   Agricultural University – Plovdiv, Genova Elka , Penov Ivan ,   Agricultural University – Plovdiv
Published: November 2021

The development of the tourism in Bulgaria and in particular of rural tourism is a way for achieving one of the CAP objectives- increased index of human development in rural areas. Through the development of tourists’ sector, it is possible to ensure an acceptable standard of living for people, to preserve the cultural heritage and at the same time to help protect the environment. There are tendencies for changes in consumer preferences from the mass forms to alternative forms of tourism. This in turn changes the entrepreneurial business in response to increased consumer interests. In the present article an assessment of a project for reconstruction of a house ("Karakusheva house" in the village of Svezhen) for rural tourism is made. Four scenarios are analyzed in which the site can operate after its construction. Recommendations for policies for the development of alternative activities in rural areas have been made.
Dynamic of the processing and trade with Bulgarian apiculture products
Authors:   Trakia University – Stara Zagora, Aleksiev Georgi
Published: November 2021

The production potential of Bulgarian beekeeping has changed dynamically over the last ten years. The transformation of the sector leads to its sustainable development but at the same time creates several problems for the realization of Bulgarian bee products at an adequate market price. The aim of the present study is to investigate the dynamics of the processing and marketing of Bulgarian apiculture products. In order to achieve this goal the following tasks need to be solved: to analyze the possibilities for realization of the Bulgarian bee products, and the analysis also focuses on the sustainability of the processing and distribution chain of these products. Methods used are analysis and synthesis, induction and deduction, statistical processing of information, etc..
Sustainable development and the role of business
Authors:   Technical University of Sofia - Branch Plovdiv, Sharkova Valeria
Published: November 2021

Sustainable development has various aspects - managerial, economic, environmental, social. It is an aspiration for politics and way of life of the population and above all - the state of the economy. The concept of sustainable development envisages economic growth that is able to meet the needs of modern society in the long run. The wheel of progress revolves only in conditions of economic freedom, respect for private property and equality before the law, which are provided by the institutional framework. People with hearts and minds - the combination of human imagination and the will to succeed - is the critical resource that provides sustainability. It works most effectively in the face of unlimited exchange of goods and services, access to knowledge and sharing of ideas, and the Internet already removes all the physical barriers to its power. All this happens not despite, but thanks to population growth, consumption of resources and wealth that maintain a closed cycle of pressure and response. Future generations will also need to keep the wheel of progress moving, so the best we can do is to preserve the framework conditions and give them the knowledge and the will.
Family farm and income support policies
Authors:   Agricultural University – Plovdiv, Zapryanova Elena , Penov Ivan ,   Agricultural University – Plovdiv
Published: November 2021

Family farms are the main form of organization in agriculture and play an essential role in the development of rural areas. One of the main characteristics of the family farms is that the members of the households work in them. The purpose of the study is, based on an analysis of a real farm and the impact of direct support on family income, to draw recommendations for policy development in this direction. In order to achieve this goal, an economic-mathematical model was developed, and eight scenarios with different levels of support were examined. The main conclusion is that the farm could operate without receiving support because the income generated by this scenario is sufficient to provide an average standard of living for the family. However, CAP support helps its faster development.
Opportunities for fiscal stimulation of the family business in tourism in crisis
Authors:   Technical University of Sofia - Branch Plovdiv, Katrandzhiev Nikolay , Konstantinova Snezhinka ,   University of Food Technologies – Plovdiv
Published: November 2021

This study presents opportunities for tax incentives for family tourism business in Bulgaria. For this purpose, a study and analysis was carried out on dynamics of tax collection and amount of local taxes for the period 2017 – 2019. On this basis was made a sample of different types of municipalities in which tourism business is prioritized – sea, mountain and spa. The variation of the amount of tourist tax paid was examined in different groups. Tax preference options are available at the municipal level for businesses in crisis, by changing legislative framework, reducing or abolishing some taxes and digitizing processes.
Identification of sources of tolerance to salinity stress in peas (Pisum sativum L.)
Authors:   Maritsa Vegetable Crops Research Institute - Plovdiv, Bulgaria, Kalapchieva Slavka , Grozeva Stanislava ,   Maritsa Vegetable Crops Research Institute - Plovdiv, Bulgaria, Tringovska Ivanka ,   Maritsa Vegetable Crops Research Institute - Plovdiv, Bulgaria
Published: November 2021

Salinity stress has become an important limiting factor for plant growth and productivity. To evaluate the effect of salinity on plant and root development three pea genotypes were grown under different concentrations of NaCl (50, 100 and 200 mM NaCI) in an in vitro and in vivo conditions. After two weeks of cultivation in culture medium the seedling emergence rate was not significantly affected by 50 mM NaCl. In culture medium containing 200 mM NaCl only in variety Prometei over 50% of the seeds developed to the plants. The data indicated that increasing NaCl level significantly reduced shoot and root lengths, and plant fresh weight. Six weeks (42 days) after sowing in vivo, a reduction in plant height and weight was observed at 200 mM NaCl concentration. A proven differences of the root traits were established only in variety Prometei. On the bases of the obtained results it can be concluded that variety Prometei was the most tolerant to applied salt stress.
Optimal design of minimal footprint high frequency transformer
Authors: Banumathy Jeyapradha Ravichandran , Veeraraghavalu Rajini
Published: November 2021

Transformer design procedure may vary essentially in respect of the
transformer type and its operating frequency (ranging between 50/60 Hz and a
few megahertz). This paper presents a simple and straightforward method
based on the optimal choice of core geometry of a high frequency transformer
(HFT) used in Solid State Transformer (SST) applications. The core of SST is
the HFT which largely influences its size and overall performance. The
proposed design procedure for HFT focuses on optimizing the core geometry
coefficient (in cm5) with a constraint inflicted on loss density. The core
geometry coefficient has direct impact on the regulation and copper loss and
the procedure results in a robust overall design with minimal footprint.
Also, the procedure intends to bring all the operating parameters like
regulation, losses and temperature rise within permissible limits while
retaining desired efficiency. Thus an energy-efficient design is achieved
with minimal footprint. The optimization procedure is implemented using
recently developed Moth-flame Optimization (MFO) algorithm. The results of
the MFO algorithm are compared with the wellestablished PSO technique. An
experimental prototype is built to validate the findings.
Analysis of watermarking techniques in multimedia communications
Authors: Sridhar Balakrishnan , Syambabu Vadlamudi
Published: November 2021

Multimedia information is critical of examining, information perceived and
which are illustrated by the human cerebrum. In our brain, 33% of the
cortical area concentrates only on visual information processing. Digital
watermarking technology is being received to guarantee and encourage such
kinds of digital data authentication, security, and copyright. These
algorithms permit the expandable values of different techniques to prevent
the problems of copyright issues during the transmission. This paper
discusses the detailed about the point by point investigation of
watermarking definition and different watermarking applications and
strategies used to improve information security.
Application of deep learning algorithms and architectures in the new generation of mobile networks
Authors: Dasic Dejan , Vucetic Miljan , Ilic Nemanja , Stankovic Milos , Beko Marko
Published: November 2021

Operators of modern mobile networks are faced with significant challenges in
providing the requested level of service to an ever increasing number of
user entities. Advanced machine learning techniques based on deep
architectures and appropriate learning methods are recognized as promising
ways of tackling the said challenges in many aspects of mobile networks,
such as mobile data and mobility analysis, network control, network security
and signal processing. Having firstly presented the background of deep
learning and related technologies, the paper goes on to present the
architectures used for deployment of deep learning in mobile networks. The
paper continues with an overview of applications and services related to the
new generation of mobile networks that employ deep learning methods.
Finally, the paper presents practical use case of modulation classification
as implementation of deep learning in an application essential for modern
spectrum management. We complete this work by pinpointing future directions
for research.
Dietary Insulinemic Potential and Risk of Total and Cause-Specific Mortality in the Nurses' Health Study and the Health Professionals Follow-up Study
Authors: Wan Yi , Tabung Fred K. , Lee Dong Hoon , Fung Teresa T. , Willett Walter C. , Giovannucci Edward L.
Published: November 2021

Objective:
Insulin
response is related to overall health. Diet modulates insulin response. We aimed
to investigate whether insulinemic potential of diet are associated with risk
of all-cause and cause-specific mortality.

Research
Design and Methods: We prospectively followed 63,464 women
from the Nurses’ Health Study (1986-2016) and 42,880 men from the Health
Professionals Follow-up Study (1986-2016). Diet was assessed by food frequency
questionnaires every 4 years. The insulinemic potential of diet was evaluated
using a food-based empirical dietary index for hyperinsulinemia (EDIH), which was
pre-defined based on predicting circulating C-peptide concentrations.

Results:
During 2,792,550 person-years of follow-up, 38,329
deaths occurred. In the pooled multivariable-adjusted analyses, a higher
dietary insulinemic potential was associated with an increased risk of mortality
from all-cause (hazard ratio [HR] comparing extreme quintiles: 1.33; 95%
confidence interval [CI]: 1.29, 1.38; P-trend<0.001), cardiovascular disease
(CVD) (HR: 1.37; 95% CI: 1.27, 1.46; P-trend<0.001), and cancers (HR: 1,20;
95% CI: 1.13, 1.28; P-trend<0.001). These
associations were independent of body mass index and remained significant after
further adjustment for other well-known dietary indices. Furthermore, compared with participants whose EDIH scores were
stable over an 8-year period, those with the greatest increases had a higher subsequent
risk of all-cause (HR: 1.13; 95%CI: 1.09, 1.18; P-trend<0.001) and CVD (HR:
1.10; 95% CI: 1.01, 1.21; P-trend=0.006) mortality.

Conclusions:
Higher insulinemic potential of diet was associated with increased risk of all-cause,
CVD, and cancer mortality. Adopting a diet with low insulinemic potential might
be an effective approach to improve overall health and prevent premature death.
Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump Therapy in Older Adults With Type 1 Diabetes (ORACL): A Randomized, Crossover Trial
Authors: McAuley Sybil A , Trawley Steven , Vogrin Sara , Ward Glenn M , Fourlanos Spiros , Grills Charlotte , Lee Melissa H , Alipoor Andisheh Mohammad , O’Neal David N , O’Regan Niamh A , Sundararajan Vijaya , Colman Peter G , MacIsaac Richard J
Published: November 2021

Objective

To assess the
efficacy and safety of closed-loop insulin delivery compared with
sensor-augmented pump therapy among older adults with type 1 diabetes.

Research Design and Methods

This open-label randomized
(1:1), crossover trial compared 4 months of closed-loop versus sensor-augmented
pump therapy. Eligible adults were aged ≥60 years, with type 1 diabetes (duration
≥10 years), using an insulin pump. The primary outcome was continuous glucose
monitoring (CGM) time in range (TIR; 3.9–10.0 mmol/L).

Results

Thirty participants
(mean age 67 years [SD 5]; median type 1 diabetes duration 38 years [IQR 20–47])
were randomized, n=15 to each sequence; all completed the trial. The mean
TIR was 75.2% (6.3) during the closed-loop stage and 69.0% (9.1) during the
sensor-augmented pump stage (difference 6.2 percentage points [95% CI 4.4, 8.0];
P <0.0001). All prespecified CGM metrics favored closed loop over
sensor-augmented pump; benefits were greatest overnight. Closed loop reduced CGM
time <3.9 mmol/L during 24 h/day by 0.5 percentage points (0.3, 1.1; P
= 0.0005) and overnight by 0.8 percentage points (0.4, 1.1; P <0.0001)
compared with sensor-augmented pump. There was no significant difference in HbA1c
between closed-loop versus sensor-augmented pump stages (7.3% [7.1–7.5] | 56
mmol/mol [54–59] versus 7.5% [7.1–7.9] | 59 mmol/mol [54–62], respectively; P
= 0.13). Three severe hypoglycemia events occurred during the closed-loop stage
and two occurred during the sensor-augmented pump stage; no hypoglycemic events
required hospitalization. One episode of diabetic ketoacidosis occurred during the
sensor-augmented pump stage; no serious adverse events occurred during the
closed-loop stage.

Conclusion

Closed-loop
therapy is an effective treatment option for older adults with long duration type
1 diabetes and no safety issues were identified. These older adults had higher TIR
accompanied by less time below range during closed-loop than sensor-augmented
pump therapy. Of particular clinical importance, closed loop reduced the time spent
in hypoglycemic range overnight.
The Atopic Dermatitis Control Tool: A High-Performance Tool for Optimal Support
Authors: Staumont-Sallé Delphine , Taieb Charles , Merhand Stephanie , Shourick Jason
Published: November 2021

The evaluation of global atopic dermatitis control is key to minimizing disease burden. The Atopic Dermatitis Control Tool (ADCT) has been developed for this purpose. Participants (diagnosed by a physician) were recruited to this observational cross-sectional study using real-life methodology and completed a questionnaire on sociodemographic and personal information. The ADCT algorithm, described by Pariser, was used to categorize patients as having controlled or uncontrolled atopic dermatitis. Data were collected for 1,606 patients. Median age of the patients was 40 years , and 1,023 (63.7%) patients were women. A total of 1,146 (71.4%) patients had uncontrolled atopic dermatitis according to the ADCT score. Patients with uncontrolled disease were at significantly higher risk of a high stress level and were more likely to be absent from work than those with controlled disease. In conclusion, a key factor for predicting disease burden in atopic dermatitis is patient self-assessed disease control in terms of multiple dimensions: stress, sleep, quality of life, work absenteeism and loss of productivity.
Grób kultury maglemoskiej w Bolkowie na Pomorzu Zachodnim
Authors: Galiński Tadeusz
Published: November 2021

W artykule omówiono grób osobnika kultury maglemoskiej odkryty w 2013 r. podczas badań wykopaliskowych na stanowisku w Bolkowie na Pomorzu Zachodnim. Obiekt zalegał w warstwach geologicznych datowanych za pomocą analizy radiowęglowej i palinologicznej na początek okresu borealnego. Kulturowo i chronologicznie wiąże się z występującym w jego bliskim sąsiedztwie rozległym obozowiskiem mezolitycznym. Przeprowadzono analizę grobu pod względem formy pochówku, praktykowanych wierzeń i obrzędów związanych z chowaniem zmarłych oraz szeroko rozumianej tradycji kulturowej. Obiekt porównano też z podobnymi znaleziskami mezolitycznymi w innych krajach.
Effect of shared decision-making education on physicians’ perceptions and practices of end-of-life care in Korea
Authors: Yu Byung Chul , Han Miyeun , Ko Gang-Jee , Yang Jae Won , Kwon Soon Hyo , Chung Sungjin , Hong Yu Ah , Hyun Young Youl , Cho Jang-Hee , Yoo Kyung Don , Bae Eunjin , Park Woo Yeong , Sun In O , Kim Dongryul , Kim Hyunsuk , Hwang Won Min , Song Sang Heon , Shin Sung Joon
Published: November 2021

Background: Evidence of the ethical appropriateness and clinical benefits of shared decision-making (SDM) are accumulating. This study aimed to not only identify physicians’ perspectives on SDM, and practices related to end-of-life care in particular, but also to gauge the effect of SDM education on physicians in Korea.Methods: A 14-item questionnaire survey using a modified Delphi process was delivered to nephrologists and internal medicine trainees at 17 university hospitals.Results: A total of 309 physicians completed the survey. Although respondents reported that 69.9% of their practical decisions were made using SDM, 59.9% reported that it is not being applied appropriately. Only 12.3% of respondents had received education on SDM as part of their training. The main obstacles to appropriate SDM were identified as lack of time (46.0%), educational materials and tools (29.4%), and education on SDM (24.3%). Although only a few respondents had received training on SDM, the proportion of those who thought they were using SDM appropriately in actual practice was high; the proportion of those who chose lack of time and education as factors that hindered the proper application of SDM was low.Conclusion: The majority of respondents believed that SDM was not being implemented properly in Korea, despite its use in actual practice. To improve the effectiveness of SDM in the Korean medical system, appropriate training programs and supplemental policies that guarantee sufficient application time are required.
ANALISIS PENGARUH KUALITAS LAYANAN TERHADAP KEPUASAN NASABAH MENGGUNAKAN ELECTRONIC BANKING
Authors: Ronny Ronny , Ilfitriah Aniek Maschudah , Nurhadi Mochamad
Published: November 2021

The purpose of this study is to analyze the effect of service quality dimensions on customer satisfaction in the use of e-banking which includes tangibles, reliability, responsibility, assurance, and empathy variables. E-banking products are limited to bank services with internet banking and mobile banking. Data was collected by distributing questionnaires to 132 respondents online to bank customers in Indonesia who have used internet banking or mobile banking. The data that has been collected is processed with the SPSS application and analyzed for validity, reliability, classical assumptions and hypothesis testing with multiple Linear Regression. The results showed that the Reliability variable and the Empathy variable had a significant effect on customer satisfaction, while the Responsiveness, Assurance, and Tangible variables had no significant effect on customer satisfaction using bank e-banking. The implication of this research is that banks need to improve reliability by maintaining the availability of internet banking and mobile banking applications so that they can be accessed by customers properly, and maintaining services that care about the problems and obstacles faced by customers in using e-banking.
Prekäre Eheschließungen
Authors: Haldemann Arno
Published: November 2021

Die vorliegende Arbeit analysiert Eheschließungen als Aushandlungsprozesse zwischen ehewilligem Eigensinn, kommunaler und familiärer Ressourcenpolitik sowie obrigkeitlicher Biopolitik. Untersuchungsraum ist die ehemals große Stadtrepublik Bern. Die Quellengrundlage bilden Ehegerichtsakten und Petitionen um Eheerlaubnis, aber auch Ehegesetze und bevölkerungspolitische Debatten.
CONTRIBUIÇÕES DO SISTEMA DIDÁTICO GALPERIN, TALÍZINA E MAJMUTOV PARA FORMAÇÃO DA HABILIDADE DE RESOLVER PROBLEMAS DISCENTES
Authors: Da Silva Oliveira Naralina Viana Soares , García Mendoza Héctor José , Tintorer Delgado Oscar
Published: November 2021

Considerando sistematizar e compreender o desenvolvimento da habilidade de resolver problemas discentes, buscou-se a utilização de um sistema didático fundamentado nos estudos de Galperin, Talízina e Majmutov. Neste sentido, o presente estudo teve como objetivo principal analisar a contribuição da utilização da Atividade de Situações Problema Discente como metodologia de ensino para o desenvolvimento da habilidade de resolver problemas na disciplina de Cálculo Diferencial e Integral nos estudantes da Licenciatura em Matemática da Universidade Federal de Pernambuco (UFPE). O caráter metodológico da pesquisa é quantitativo e qualitativo, com enfoque predominante qualitativo. Após a realização da experiência formativa, observou-se que aproximadamente 65% da turma demonstrou que consegue transferir os conhecimentos conceituais e procedimentais de derivadas, se encontrando com as características que são específicas da etapa verbal externa. Todavia, 35% da turma apresentou dificuldades em transferir para novas situações os conhecimentos trabalhados anteriormente, se encontrando na transição entre a etapa materializada e a etapa verbal externa.
Effects of His-Phe-Arg-Trp-Pro-Gly-Pro peptide on free-radical oxidation processes in conditions of chronic restraint stress
Authors: Vorvul AO , Bobyntsev II , Medvedeva OA , Azarova IuE , Belykh AE , Andreeva LA
Published: November 2021

Studying the effects of regulatory peptides on the stress-induced shifts in the bodily processes is of great fundamental and applied significance. Currently, a wide range of peptide neurotropic drugs, affecting the stress response development, are used in medicine, and new promising molecules are being studied. The study was aimed to assess the effects of the adrenocorticotropic hormone (ACTH) synthetic analog, ACTH(6-9)-Pro-Gly-Pro, administered at a dose of 5, 50 and 500 μg/kg, on the free-radical oxidation processes in Wistar rats, subjected to chronic restraint stress (CRS) during two weeks. Serum levels of 8-oxo-2'-deoxyguanosine (8-OHdG) and superoxide dismutase 3 (SOD3) were assessed by enzyme immunoassay, and the levels of thiobarbituric acid reactive substances (TBARS) were assessed by fluorimetric method. CRS lead to the significant increase in the 8-OHdG levels by 18.4% (p = 0.01) and the decrease in the SOD3 levels by 14.3% (p = 0.01), however, it had no effect on the levels of TBARS. ACTH(6-9)-Pro-Gly-Pro, administered at a dose of 5 and 50 μg/kg, significantly decreased the levels of 8-OHdG by 19.8% (p = 0.03) and 30% (p = 0.001), respectively. Thus, it was found that CRS resulted in oxidative stress in animals. ACTH(6-9)-Pro-Gly-Pro administration at a dose of 5 and 50 μg/kg inhibits the stress-induced free-radical oxidation processes.
Vliyanie peptida His-Phe-Arg-Trp-Pro-Gly-Pro na processy svobodnoradikal'nogo okisleniya v usloviyah hronicheskogo immobilizacionnogo stressa
Authors: Ворвуль А. О. , Бобынцев И. И. , Медведева О. А. , Азарова Ю. Э. , Белых А. Е. , Андреева Л. А.
Published: November 2021

Izuchenie vliyaniya regulyatornyh peptidov na razvitie stress-inducirovannyh sdvigov v organizme imeet vazhnoe fundamental'noe i prikladnoe znachenie. V nastoyashchee vremya v medicine ispol'zuyut celyj ryad nejrotropnyh preparatov peptidnoj prirody, okazyvayushchih vliyanie na razvitie stressornoj reakcii, a takzhe vedut issledovanie novyh perspektivnyh molekul. Cel'yu raboty bylo izuchit' effekty sinteticheskogo analoga adrenokortikotropnogo gormona (AKTG) AKTG(6-9)-Pro-Gly-Pro v dozah 5, 50 i 500 mkg/kg na processy svobodnoradikal'nogo okisleniya u krys Vistar v usloviyah dvuhnedel'nogo hronicheskogo immobilizacionnogo stressa (HIS). Urovni 8-okso-2'-dezoksiguanozina (8-OHdG) i superoksiddismutazy 3 (SOD3) v syvorotke krovi ocenivali s primeneniem immunofermentnogo analiza, a urovni produktov, reagiruyushchih s tiobarbiturovoj kislotoj (TBK-RP), ocenivali fluorimetricheskim metodom. HIS privodil k znachimomu povysheniyu urovnya 8-OHdG na 18,4% (p = 0,01) i snizheniyu SOD3 na 14,3% (p = 0,01), no ne vliyal na uroven' TBK-RP. Primenenie AKTG(6-9)-Pro-Gly-Pro v dozah 5 i 50 mkg/kg znachimo snizhalo soderzhanie 8-OHdG na 19,8% (p = 0,03) i 30% (p = 0,001) sootvetstvenno. Takim obrazom, ustanovleno, chto HIS privodit k razvitiyu okislitel'nogo stressa u zhivotnyh. Vvedenie AKTG(6-9)-Pro-Gly-Pro v dozah 5 i 50 mkg/kg okazyvaet ingibiruyushchee vliyanie na stress-inducirovannye processy svobodnoradikal'nogo okisleniya.
Pengalihan Wakaf oleh Sarak Opat di Aceh Tengah Ditinjau Hukum Islam dan Hukum Adat
Authors: Kusmayanti Hazar
Published: November 2021

Waqf is one of the institutions of Islamic social institutions that contain socio-economic values that are expected to help to realize social welfare that benefits can be enjoyed together. However, there are many problems related to waqf land, one of which is the change in the designation of waqf land-based on adat meetings.  The purpose of this thesis is to examine the legal position of waqf land that has changed its designation and implementation of waqf in Central Aceh District based on Islamic Law and Customary Law in terms of the Law. The research in this thesis uses the normative juridical approach The specification of the research conducted is analytical descriptive. Based on the results of this study, the legal status of waqf land that has been represented cannot be used if it is not in accordance with the waqf pledge, but there are exceptions to the waqf land that can be changed its designation and must follow the procedure for changes stipulated by Law Number 41 of 2004 Execution of existing land parcels in Central Aceh Regency, Islamic Law has been implemented correctly, but the state administration has not been implemented to the maximum.
Urgensi Fatwa DSN-MUI Mengenai Manajemen Risiko Pembiayaan Berbasis Syariah
Authors: Hidayati Tri , Hidayatullah Muhammad Syarif
Published: November 2021

Risk management at Islamic financial institutions is still implementing bank Indonesia (BI) and Financial Services Authority (OJK) policies which previously applied the same to conventional financial institutions. The perfection of the enforcement of sharia principles in sharia financing institutions is not enough only in the aspect of transactional mechanisms, it needs to be supported by a sharia-based risk management system. The focus of this research includes the characteristics of Islamic financing, juridical aspects in the principle of prudence, and an overview of the maslahah of the urgency of sharia-based risk management. This research is normative legal research using a statutory approach and a benefits approach with a qualitative descriptive analysis. The results of the discussion show that a dynamic system also needs to be supported by juridical aspects to provide the legal force with the realization of regulatory solidity. At this regulatory level, in addition to the regulations issued by the OJK, the DSN-MUI fatwa is also very necessary and has a very urgent position. Because financing risk management is also part of the sharia economy that must maintain sharia principles, lest the application of sharia principles only exists in product technicalities, but does not apply to technical risk management. The expected sharia is the application of total sharia principles (kaffah), not partial ones.