bluuebunny/crossref_metadata_2025 huggingface dataset:
Gas chromatography/combustion/isotope ratio mass spectrometric analysis of the stable carbon composition of tetrols
Authors: Wang Wu , Li Li , Li Huaijian , Zhang Dongping , Wen Shen , Jia Wanglu , Wang Bangjin , Sheng Guo ying , Fu Jiamo
Published: July 2009

The stable carbon isotope compositions of tetrols, erythritol and threitol were determined by gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS). Using four tetrols with various δ13C values derivatized by methylboronic acid, the carbon isotope analysis method achieved excellent reproducibility and high accuracy. There was no carbon isotopic fractionation during the derivatization processes. The differences in the carbon isotopic compositions of methylboronates between the measured and calculated ranged from −0.20 to 0.12‰, within the specification of the GC/C/IRMS system. It was demonstrated that δ13C values of tetrols could be calculated by a simple mass balance equation between tetrols, methylboronic acid, and methylboronates. The analogous 2‐methyltetrols, marker compounds of photooxidation products of atmospheric isoprene, should have similar behavior using the same derivatization reagent. This method may provide insight on sources and sinks of atmospheric isoprene. Copyright © 2009 John Wiley & Sons, Ltd.
Targeted analysis of protein citrullination using chemical modification and tandem mass spectrometry
Authors: Stensland Maria , Holm Anders , Kiehne Andrea , Fleckenstein Burkhard
Published: July 2009

Protein citrullination originates from enzymatic deimination of polypeptide‐bound arginine and is involved in various biological processes during health and disease. However, tools required for a detailed and targeted proteomic analysis of citrullinated proteins in situ, including their citrullination sites, are limited. A widely used technique for detection of citrullinated proteins relies on antibody staining after specific derivatization of citrulline residues by 2,3‐butanedione and antipyrine. We have recently reported on the details of this reaction. Here, we show that this chemical modification can be utilized to specifically detect and identify citrullinated peptides and their citrullination sites by liquid chromatography/tandem mass spectrometry (LC/MS/MS) analysis. Using model compounds, we demonstrate that in collision‐induced dissociation (CID) a specific, modification‐derived fragment ion appears as the dominating signal at m/z 201.1 in the MS/MS spectra. When applying electron transfer dissociation (ETD), however, the chemical modification of citrulline remained intact and extensive sequence coverage allowed identification of peptides and their citrullination sites. Therefore, LC/MS/MS analysis with alternating CID and ETD has been performed, using CID for specific, signature ion‐based detection of derivatized citrullinated peptides and ETD for sequence determination. The usefulness of this targeted analysis was demonstrated by identifying citrullination sites in myelin basic protein deiminated in vitro. Combining antibody‐based enrichment of chemically modified citrulline‐containing peptides with specific mass spectrometric detection will increase the potential of such a targeted analysis of protein citrullination in the future. Copyright © 2009 John Wiley & Sons, Ltd.
The impact of designing and evaluating molecular animations on how well middle school students understand the particulate nature of matter
Authors: Chang Hsin‐Yi , Quintana Chris , Krajcik Joseph S.
Published: July 2009

In this study, we investigated whether the understanding of the particulate nature of matter by students was improved by allowing them to design and evaluate molecular animations of chemical phenomena. We developed Chemation, a learner‐centered animation tool, to allow seventh‐grade students to construct flipbook‐like simple animations to show molecular models and dynamic processes. Eight classes comprising 271 students were randomly assigned to three treatments in which students used Chemation to (1) design, interpret, and evaluate animations, (2) only design and interpret animations, or (3) only view and interpret teacher‐made animations. We employed 2‐factor analysis of covariance and calculated effect sizes to examine the impact of the three treatments on student posttest performances and on student‐generated animations and interpretations during class. We used the pretest data as a covariate to reduce a potential bias related to students' prior knowledge on their learning outcomes. The results indicate that designing animations coupled with peer evaluation is effective at improving student learning with instructional animation. On the other hand, the efficacy of allowing students to only design animations without peer evaluation is questionable compared with allowing students to view animations. © 2009 Wiley Periodicals, Inc. Sci Ed 94:73–94, 2010
Students' use of decision‐making strategies with regard to socioscientific issues: An application of the Rasch partial credit model
Authors: Eggert Sabina , Bögeholz Susanne
Published: July 2009

Decision making about socioscientific issues is an important aspect of modern science education worldwide. Among the many topics that represent socioscientific issues, issues relating to the sustainable development of our environment are one crucial topic. However, difficulties exist with respect to the assessment of teaching outcomes related to these issues. This paper presents results from two quantitative studies that were conducted to develop a test instrument that measures students' use of decision‐making strategies in situations relating to sustainable development. Data were analyzed using the Rasch partial credit model. Analyses concerning reliability and validity showed that the developed instrument provides an adequate measure of students' use of decision‐making strategies. Analyses indicated that the test instrument can be used among different age groups and that decision‐making competence increases with respect to years of education. Most elaborate strategies were characterized by the use of trade‐offs, the ability to weigh decision criteria, and the ability to reflect on the structure of decision‐making processes. In contrast, baselevel strategies were characterized by the use of cutoffs and an absence of elaborate metareflection. The results provide a valuable starting point for analyzing and fostering students' decision‐making competence in the science classroom. © 2009 Wiley Periodicals, Inc. Sci Ed 94:230–258, 2010
Altered expression and alpha‐1 adrenergic receptor mediated activity of protein kinase C in the prefrontal cortex of rats with neonatal ventral hippocampus lesions
Authors: Al‐Khairi Irina , Baharnoori Moogeh , Kamath Aarthi , Bhardwaj Sanjeev K. , Srivastava Lalit K.
Published: July 2009

The neonatal ventral hippocampus (nVH) lesion in rats captures many features of schizophrenia at the levels of behavior and neurobiological markers. We have previously reported enhanced expression of α‐1 adrenergic receptors (AR) in the prefrontal cortex (PFC) of postpubertal nVH‐lesioned rats and proposed that enhanced α‐1 AR signaling might participate in some of the behavioral abnormalities observed in the nVH‐lesioned rats. To assess the components of α‐1 adrenergic signaling in nVH‐lesiond rats, we examined prefrontal cortical expression of protein kinase C (PKC) subtypes by Western blotting and α‐1 AR‐stimulated PKC activity by in vitro enzyme assay in postpubertal animals. Neonatal VH‐lesioned animals showed significantly increased expression of membrane‐bound PKC‐α and the phosphorylated form of PKC. Cytosolic PKC‐βII and PKC‐γ expression were found to be decreased in the PFC of lesioned animals with no change in the expression of PKC‐βI either in the cytosol or membrane. PKC activity assays showed an increase in basal PKC activity in the PFC slices of nVH‐lesioned animals. Stimulation of α‐1 adrenergic receptor with different concentrations of the agonist phenylephrine (PE), while increasing PKC activity in the sham‐lesioned animals surprisingly decreased the activity in nVH‐lesioned animals. Increased basal levels as well as activity of prefrontal PKC and its anomalous regulation by α‐1 adrenergic receptors may participate in the cognitive and stress‐induced behavioral alterations in nVH‐lesioned animals. Synapse 63:1051–1059, 2009. © 2009 Wiley‐Liss, Inc.
Second‐by‐second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats
Authors: Konradsson‐Geuken Åsa , Gash Clelland R. , Alexander Kathleen , Pomerleau Francois , Huettl Peter , Gerhardt Greg A. , Bruno John P.
Published: July 2009

These experiments utilized an enzyme‐based microelectrode selective for the second‐by‐second detection of extracellular glutamate to reveal the α7‐based nicotinic modulation of glutamate release in the prefrontal cortex (PFC) of freely moving rats. Rats received intracortical infusions of the nonselective nicotinic agonist nicotine (12.0 mM, 1.0 μg/0.4 μl) or the selective α7 agonist choline (2.0 mM/0.4 μl). The selectivity of drug‐induced glutamate release was assessed in subgroups of animals pretreated with the α7 antagonist, α‐bungarotoxin (α‐BGT, 10 μM), or kynurenine (10 μM) the precursor of the astrocyte‐derived, negative allosteric α7 modulator kynurenic acid. Local administration of nicotine increased glutamate signals (maximum amplitude = 4.3 ± 0.6 μM) that were cleared to baseline levels in 493 ± 80 seconds. Pretreatment with α‐BGT or kynurenine attenuated nicotine‐induced glutamate by 61% and 60%, respectively. Local administration of choline also increased glutamate signals (maximum amplitude = 6.3 ± 0.9 μM). In contrast to nicotine‐evoked glutamate release, choline‐evoked signals were cleared more quickly (28 ± 6 seconds) and pretreatment with α‐BGT or kynurenine completely blocked the stimulated glutamate release. Using a method that reveals the temporal dynamics of in vivo glutamate release and clearance, these data indicate a nicotinic modulation of cortical glutamate release that is both α7‐ and non‐α7‐mediated. Furthermore, these data may also provide a mechanism underlying the recent focus on α7 full and partial agonists as therapeutic agents in the treatment of cortically mediated cognitive deficits in schizophrenia. Synapse 63:1069–1082, 2009. © 2009 Wiley‐Liss, Inc.
Papal Finance and the Temporal Power, 1815–1871
Authors: Cameron Rondo E.
Published: July 2009

The Popes of Rome ruled as both temporal and spiritual sovereigns for more than one thousand years, but historians have been little concerned with the former aspect of their sovereignty except as a factor in international politics and diplomacy and for its effect upon their status as heads of Catholic Christendom. Details of the internal administration of the States of the Church have been largely neglected. This state of affairs is particularly true with respect to the modern and recent periods of European history, during which the rise of great national states eclipsed the tiny temporal domain of the Pope. There is a substantial literature on the finances of the Papacy in the later Middle Ages, when finance is recognized as having played an important part in political affairs, but a survey of the literature for the modern period fails to reveal any systematic treatment of the subject. There is reason to believe, however, as this brief note indicates, that there is a significant connection between the financial situation of the States of the Church and the loss of the temporal power. It is even possible that this connection extends to matters of Church doctrine.
The White Crown of Works: Cyprian's Early Pastoral Ministry of Almsgiving in Carthage
Authors: Dunn Geoffrey D.
Published: July 2009

In a letter from Cyprian, bishop of Carthage in the middle of the third century, written while he was in hiding during the Decian persecution to the imprisoned confessors in Carthage, there is mention of two crowns, two colors and two flowers. The letter can be dated to the middle of April 250. Cyprian wanted to console those in prison that they would not be failures if they failed to be martyred. Those who were not martyred could receive equal renown through their confession as those who were martyred. As much as martyrdom was highly prized among African Christians, Cyprian wanted to assure the imprisoned confessors that it was not the only way to please God. In the past (ante), in a time undoubtedly before persecution, one could be clad in white for good works, just as now one could be clad in crimson for martyrdom. For those who were not going to die a martyr's death and win the crimson crown for suffering or the flower of warfare, Cyprian seemed to say that the confession of their faith could now be counted as a good work for which the reward was the white crown or the flower of peace.
Reversing the Curse: Agricultural Millennialism at the Illinois Industrial University
Authors: Smith Brett H.
Published: July 2009

In the spring of 1868, sixty-eight students gathered to become the first matriculants of the Illinois Industrial University. They had responded to a summons by the state legislature to engage in a bold new mission of publicly funded mechanical and industrial education, a move which would, Illinoisans hoped, bring lavish prosperity to their fellow citizens and themselves. Like other colleges of the period, utilitarian and democratic rationales motivated the I. I. U. leadership to establish their school. Quoting their commission by the Morrill Act, the trustees said the university's “chief aim” was to educate “the industrial classes” by teaching “such branches of learning as are related to Agriculture and the Mechanic Arts, and Military Tactics, without excluding other scientific and classical studies.” And yet, there was an even more radical and compelling vision among the I.I.U. faithful, one which was distinctively theological: “The hope of the Trustees and Faculty,” they said, “is that the Institution will produce … men of Christian culture … able and willing to lend a helping hand in all the great practical enterprises of this most practical age.”
The 1904–05 Welsh Revival: Modernization, Technologies, and Techniques of the Self
Authors: Gitre Edward J.
Published: July 2009

Surveying the short history of pentecostalism in 1925, Frank Bartelman—a consummate “insider historian”—reckoned that although the Azusa Street revival had become “full grown” in Los Angeles, California, it was “rocked in the cradle of little Wales.” In pentecostal historiography much ink has been spilled connecting the causal dots of precedence. From whence did the movement come? Los Angeles? India? Topeka, Kansas? Historians of pentecostalism are cognizant of the 1904–05 Welsh revival; they readily acknowledged that it in some way influenced the Apostolic Faith Mission in Los Angeles. My goal here is not necessarily to argue one way or another but rather to resurrect from the dustbin of history a significant event that deserves its own due. This is a story, argues historian Rhodri Hayward, that “has been largely forgotten.”
Conduits of Faith: Reinhold Niebuhr's Liturgical Thought
Authors: Bains David R.
Published: July 2009

The mid twentieth century was an important period of theological and liturgical change for mainline Protestants. Theologically, the optimistic liberalism of the turn of the century came under sharp critique from a variety of theologians who sought to give greater attention tc the historic Christian doctrines. Liturgically, the practices of evangelicalism were compared to historic models of Christian worship and found wanting. No American was more prominent in the theological critique than Reinhold Niebuhr (1892–1971). After rising to national prominence as a preacher and essayist while serving as a pastor ir Detroit, Michigan, he joined the faculty of Union Theological Seminary in New York City in 1928 and gained an international reputation as a social ethicist, preacher, and advocate of a theological perspective known variously as “Christian realism” or “neo-orthodoxy.” It is less well known that as part of his theological program Niebuhr advocated liturgical reform. From his days in Detroit when he confessed devoting an entire fall “to a development of our worship services” to the height of his career when he warned that “a church without adequate conduits of traditional liturgy” is “without the waters of life,” Niebuhr was vitally concerned with “the weakness of common worship in American Protestantism.”
“A Suitable Abode for Christ”: The Church Building as Symbol of Ascetic Renunciation in Early Monasticism
Authors: Schroeder Caroline T.
Published: July 2009

In reading many early Christian texts from and about Egypt, one is struck by the importance of space for the ascetic lifestyle. Whether it be Antony locked in his desert fortress, the tightly arranged cells of Kellia in theApopthegmata Patrum, or the landscape of the desert in so much hagiographical literature, the space in which the early Christians practiced ascetic renunciation was as infused with as much meaning as the ascetic practices themselves. Since few texts with descriptions of early ascetic space survive, studies have been left largely to archaeologists and art historians, not historians of Christianity. Only a handful of ascetic authors from the fourth through sixth centuries wrote about the theological significance they found in the building of churches. These include the wealthy Latin patron Paulinus of Nola (Italy), two anonymous members of the Pachomian monasteries in Egypt, and the Egyptian archimandrite Shenoute. The churches built for each of these late antique communities held deep theological significance. They symbolized the ascetic endeavors undertaken at those communities. Since for each writer, the ascetic struggle was constituted in slightly different terms, with different goals, practices, and interpretations of those practices, so were the church buildings imbued with different meanings. Yet, in each case, the church held meaning beyond its mere walls. Each was constructed as much by a theology and a discourse of ascetic discipline as it was by wood, brick, and stone.
Miracles, Early Modern Science, and Rational Religion
Authors: Harrison Peter
Published: July 2009

Readers of the New Testament could be excused for thinking that there is little consistency in the manner in which miracles are represented in the Gospels. Those events typically identified as miracles are variously described as “signs” (semeia), “wonders” (terata), “mighty works” (dunameis), and, on occasion, simply “works” (erga). The absence of a distinct terminology for the miraculous suggests that the authors of the Gospels were not working with a formal conception of “miracle”—at least not in that Humean sense of a “contravention of the laws of nature,” familiar to modern readers. Neither is there a consistent position on the evidentiary role of these events. In the synoptic Gospels—Matthew, Mark, and Luke—Jesus performs miracles on account of the faith of his audience. In John's Gospel, however, it is the performance of miracles that elicits faith. Even in the fourth Gospel, moreover, the role of miracles as signs of Christ's divinity is not straightforward. Thus those who demand a miracle are castigated: “Unless you see signs and wonders you will not believe.” Finally, signs and wonders do not provide unambiguous evidence of the sanctity of the miracle worker or of the truth of their teachings. Accordingly, the faithful were warned (in the synoptic Gospels at least) that “false Christs and false prophets will rise and show signs and wonders [in order] to deceive.”
Hesitant Steps: Acceptance of the Gregorian Calendar in Eighteenth-Century Geneva
Authors: McNutt Jennifer Powell
Published: July 2009

History demonstrates that the calendar is a tool of far more significance than simply a means to organize units of time. For Roman high priests prior to the reign of Julius Caesar, the calendar was a tool of power, symbolizing political supremacy over society through the manipulation of time at will. Under Pope Gregory XIII, the calendar was a symbol of papal responsibility to ensure the proper worship of the Catholic Church. In the case of European Protestants, the Julian calendar was a symbol of religious identity and protest against Catholic domination. Likewise, within revolutionary France, theCalendrier Républicainsymbolized the rejection of theAncien Régimeand Catholicism. These few examples are an indication that throughout history in various times and places calendars have proven to represent more to humanity than mere time reckoning methods. Consequently, one may approach the study of the calendar as a means to grasp cultural and religious identity within specific regional contexts.
Houses of Healing: Sacred Space, Spiritual Practice, and the Transformation of Female Suffering in the Faith Cure Movement, 1980–90
Authors: Curtis Heather D.
Published: July 2009

In the autumn of 1876, while attending the nation's Centennial celebration, Miss Harriet M. Barker contracted a case of typhoid fever that left her crippled. While she managed to “get about” on crutches for several years, Barker's health “was gradually failing.” By the spring of 1881, she was “completely prostrated.” For the next four years, Barker remained a “helpless invalid” whose case “seemed to baffle even the best medical skill.” Although she tried various treatments, “all remedies were of but little avail,” and her physicians eventually deemed her incurable, predicting that she had only a few months to live, at most. “During all these years of suffering,” Barker later recounted, “I prayed so earnestly for patience and resignation to God's will, and for the most part rested quietly, and, as I believed, submissively, under what I felt was His needed teaching of me.” But as “the weary years dragged on,” Barker recalled, “I began to think of the subject of Divine Healing.” At first, she reported, the possibility of healing by faith “seemed a great way off—something for only a chosen few.” Although she became “more convinced of the reality of this belief” through discussions with friends who were “deeply interested” in the possibility of faith cure, Barker confessed that she “was still much in the dark about the matter” and could not “see it clearly enough to grasp it for myself.”
From Saint to Seeker: Teresa Urrea's Search for a Place of Her Own
Authors: Bayne Brandon
Published: July 2009

On Monday, December 15, 1902, theLos Angeles Timesproclaimed the feted arrival of the famed “Mystic Santa Teresa.” The paper regaled its readers with the circus like events that surrounded her arrival to the burgeoning West Coast metropolis: “Santa Teresa, the famous Mexican girl from the land of the Yaqui, in Sonora, who is implicitly believed in by the majority of Mexicans of the Southwest as a healer, who exercises supernatural powers, has settled in Los Angeles permanently, her followers say, and is daily besieged by a pitiful throng of Mexican ‘enfermos.’” According to theTimes, wagonloads of hopeful “invalids” made the pilgrimage to Teresa's cottage at the corner of Brooklyn and State in the “Sonoratown” area of East LA. Noting the “Stream of Mexicans Flowing to Her Cottage,” it listed the diverse range of desperate immigrants seeking her healing touch: “The halt, the blind, the inwardly diseased, paralytics, almost helpless and others with bodies ravaged by consumption, are helped to her doors each day by friends and relatives; and none go there without the belief that by the laying on of her magic hands they will be cured.” The reporter attributed all the excitement to the inexorable pull exerted by this “magnetic young woman from the South.” He blithely summarized, “Santa Teresa … has been the subject of many fantastic stories, based more or less on fact. In some ways her influence is really remarkable.”
The Heretic Saint: Guglielma of Bohemia, Milan, and Brunate
Authors: Newman Barbara
Published: July 2009

High above Lake Como in Lombardy, overlooking the cathedral city of Como and the southwestern branch of the lake, looms the tiny village of Brunate. It is a picturesque spot, beloved of mountain climbers, which enjoyed a brief heyday as a tourist mecca in the late nineteenth and early twentieth centuries. An efficient if ear-popping funicular railway, inaugurated in 1894, now scales the steep cliff in a brisk seven minutes. But in the Middle Ages, when most of our story is set, Brunate was as remote and inaccessible a site as one could hope to find. A hagiographer around 1600 described it as an “ignoble village on that mountain whose vast ridge towers above the city to the east.… The mountain is arduous and laborious to climb.” In 1578 the village had a mere 156 inhabitants, and as late as 1900 its year-round population was barely over 500.
What Would Jesus Do? Sexuality and Salvation in Protestant Evangelical Sex Manuals, 1950s to the Present
Authors: DeRogatis Amy
Published: July 2009

When President Bill Clinton testified before a Grand Jury hearing on August 17, 1998 that he “did not have sexual intercourse with that woman, Miss Lewinsky,” the American public learned at least two important lessons. First, the definition of sex was debatable and second, the authority to define sex as sexual intercourse was the crucial factor in the meaning of that pesky verb “is.” The questions of what is sex and, more importantly, who defines it have been studied and discussed thoroughly by scholars of U.S. history and culture. In American popular culture the social scientific findings published in the Kinsey Reports (1948, 1953) and William H. Masters and Virginia E. Johnson's Human Sexual Response (1966) provided information (or “scientific facts”) for lay people regarding the diversity and possibility of human sexual expression: what sex “is.” The growing awareness since the late 1950s that sex is more than one specific act has led many people to question whether sex as we learn it from our parents, teachers, clergy, friends, books, and science is “natural” (a matter of biological response) or socially constructed (a matter of cultural control). Opinions vary, tempers flare, and the mountain of sex advice manuals available at local bookstores attests to the U.S. public's insatiable appetite for knowledge about sex.
African American Religious Intellectuals and the Theological Foundations of the Civil Rights Movement, 1930–55
Authors: Dickerson Dennis C.
Published: July 2009

Among the innumerable warriors against legalized racial segregation and discrimination in American society, the iconic Martin Luther King, Jr. emerged as a principal spokesman and symbol of the black freedom struggle. The many marches that he led and the crucial acts of civil disobedience that he spurred during the 1950s and 1960s established him and the Southern Christian Leadership Conference as rallying points for civil rights activities in several areas in the American South. King's charisma among African Americans drew from his sermonic rhetoric and its resonance with black audiences. Brad R. Braxton, a scholar of homiletics, observed that King as a black preacher “made the kinds of interpretive moves that historically have been associated with African American Christianity and preaching.” Braxton adds that “for King Scripture was a storybook whose value resided not so much in the historical reconstruction or accuracy of the story in the text, but rather in the evocative images, in the persuasive, encouraging anecdotes of the audacious overcoming of opposition, and in its principles about the sacredness of the human person.” Hence, King's use of this hermeneutical technique with scriptural texts validated him as a spokesman for African Americans. On a spectrum stretching from unlettered slave exhorters in the nineteenth century to sophisticated pulpiteers in the twentieth century, King stood as a quintessential black preacher, prophet, and jeremiad “speaking truth to power” and bringing deliverance to the disinherited.
Philosophy as Training for Death: Reading the Ancient Christian Martyr Acts as Spiritual Exercises
Authors: Kelley Nicole
Published: July 2009

In recent years several notable studies—including those by Judith Perkins, Daniel Boyarin, and Elizabeth Castelli—have assessed the importance of martyrdom and suffering in constructions of ancient Christian identity. This essay takes as its starting point the observation by Perkins that in early Christian communities, the threat of suffering (whether real or perceived) worked to create a particular kind of self. In Perkins's view, many ancient Christians came to believe that “to be a Christian was to suffer.” Christian martyr acts, when understood as textual vehicles for the construction of culture and the articulation of Christian identities, emerge as one mechanism by which such selves were constructed. In the pages that follow I will explore how the reading and hearing of narratives about martyrdom constituted an exercise derived from Greek philosophy, adapted to inspire a largely nonliterate audience. This exercise not only trained early Christians to be ready for death and the world to come, but also worked to shape their perceptions of the Christian way of life in this world.
The Real Presence of Mary: Eucharistic Disbelief and the Limits of Orthodoxy in Fourteenth-Century France
Authors: Anderson Wendy Love
Published: July 2009

On July 15, 1318, a twenty-six-year-old laywoman named Aude Fauré was called before the Inquisition tribunal at the diocesan seat of Pamiers in southern France and immediately confessed to having temporarily doubted both the real presence of Christ in the Eucharist and the transubstantiation of bread and wine into Christ's body and blood; her doubt, she explained, had been cured by intervention from the Blessed Virgin. Less than a month later, Aude abjured her errors by the usual formula and was sentenced to a series of pilgrimages and fasts stretching over the next three years. Aude's multiple confessions, along with depositions from her family, friends, and neighbors, take up a mere six folio pages in the famously detailedRegisterkept by Bishop Jacques Fournier, head of the Pamiers tribunal, and preserved in the Vatican Library after Fournier became Pope Benedict XII. This relatively quick-moving and insignificant case seems unrelated to the best-known activity of Fournier's tribunal, namely, the extinction of the last vestiges of Occitan Catharism. Yet Aude's case has gleaned several mentions in recent historiographic works, and these mentions are striking for their focus on the protagonist's psyche: she has been variously diagnosed as hypersensitive, neurotic, masochistic, morbid, hysterical, obsessive, afflicted with atheism, prone to fantasy, tormented by guilt, suffering from postpartum depression, and simply deviant.
The Origins of Southern Evangelicalism: Revivalism in South Carolina, 1700–1740
Authors: Little Thomas J.
Published: July 2009

Despite the continuing “discovery of southern religious history” and the growing scholarly fascination with southern intellectual and cultural history, historians of the South have devoted all too little attention to the origins of southern evangelicalism in the colonial period. Over the past thirty years or so, they have generally tended to follow the lead of Samuel S. Hill, Jr., arguably the single most important and influential southern religious historian, who concluded in an interpretive survey article that “the history of religion in the South before it was the South … is, in all candor, not very impressive.” In his pioneeringReligion in the Old South, for instance, Donald G. Mathews paid but scant attention to the origins of popular Protestantism in the South during the middle decades of the eighteenth century. What is more, he focused almost exclusively on colonial Virginia.
The Mysticism of the School of Saint Victor
Authors: Healy Patrick Joseph
Published: July 2009

The School of St. Victor derived its name from the monastery, or rather priory, of St. Victor, situated near Paris. The monastery became a school when William of Champeaux, in 1108, gave up his chair of philosophy at the Cathedral school in Paris and retired there to devote his life to monastic seclusion. His reputation as a teacher was such that students followed him to the monastery and at their insistence he resumed his career as teacher, and continued to give lectures until he was promoted to the bishopric of Chalons-sur-Marne. The place, however, owes its fame as a center of philosophical studies not to William of Champeaux, but primarily to Hugh the founder of its system of mysticism and in a less degree to Richard the scholar, and to Adam the poet. Hugh of St. Victor, in the opinion of his contemporaries and of some of the most discriminating of modern writers, deserves to rank not only with the greatest of the philosophers and theologians of the twelfth century but of the entire Middle Ages. He was an indefatigable student, a man of broad culture, of independent judgment, and a scholar who influenced profoundly the course of philosophical and theological thought and speculation. Though there is considerable discussion as to his nationality it seems reasonably certain that he received his early education in the monastery of Hamersleben near Halberstadt. It was in order to become a student of William of Champeaux that he came to Paris and to the monastery of St. Victor. He commenced to teach in 1115, and from 1133 until his death in 1141 he was the head of the school. The reproach which was so frequently brought against Hugh that he was opposed to profane science is shown by Ueberweg-Baum-gartner to be utterly without foundation, and it is clearly proved that he was interested in all science, and that he was convinced that secular art and science are valuable auxiliaries in the promotion of theological knowledge. His writings embrace treatises on theology, philosophy and exegesis, together with several works dealing expressly with mysticism or contemplation. The best known of these works on the subject of mysticism are De Contemplatone et ejus Speciebus, De Meditando, De Amore Sponsi ad Sponsam, De Arca Noe Mystica, De Arca Noe Morali, De Vanitate Mundi, De Arrha Animae, De Laude Caritatis, De Modo Orandi.
Domine Everhardus Bogardus
Authors: Breen Quirinus
Published: July 2009

It was long believed that Domine Everhardus Bogardus was the first minister of the colony in New Netherland. This opinion was corrected when in 1857 there was discovered a now famous letter by Domine Jonas Michaëlius, the actual first minister, to Domine Smoutius of Amsterdam.
Factors in the Development of Modern Biblical Study
Authors: Riddle Donald Wayne
Published: July 2009

The impression which is likely to be derived from the reading of a history of biblical interpretation is that modern criticism is a goal which has been attained by an evolution in which the curve of progress is fairly steady and constant. There seems to be a tacit assumption that such adjectives as “modern,” “critical,” and “scientific” as applied to biblical studies are synonymous and equally deserved. The occasional appearance of a critical judgment in the work of ancient worthies is regarded as an “anticipation” of modern views. In most histories of interpretation the beginnings of modern criticism are found in the Renaissance and the Reformation, so that Luther and Calvin are regarded as biblical scholars; the importance of New Testament studies in the work of Erasmus is exaggerated, and processes of scientific criticism are pictured as in effect before the impact of discovery brought a new world-view into being.
The Synod of Michigan and Movements for Social Reform, 1834–1869
Authors: Velde L. G. Vander
Published: July 2009

Presbyterians are fond of pointing out that their General Assembly was organized in the year which witnessed the adoption of our Federal Constitution, and that the republican organization of their central government corresponds in many respects to that of the “more perfect Union” which the people of the United States decided in 1788 to set up. Michigan Presbyterians may with reason cite a parallel coincidence in dates of establishment: the Synod of Michigan was founded in September, 1834, only about six months before the people of the territory elected delegates to draw up a state constitution. From this common chronological beginning, both Michigan organizations developed rapidly, and naturally their histories were closely related.
Church and State in Italy During the Last years of Pius IX
Authors: Halperin S. William
Published: July 2009

During the closing years of Pius IX's pontificate the relations between church and state in Italy were marred by incessant and acrimonious strife. The occupation of Rome on September 20, 1870 had widened the breach between the civil and ecclesiastical authorities. The subsequent course of this feud brought no attenuation of existing animosities. The implacable hostility of the Vatican to the new order of things in the peninsula spurred the Italian government to take drastic measures against the church and its recalcitrant hierarchy. Decisive too in the launching of this concerted offensive was the eagerness of the country's rulers to accelerate the secularization of Italian life. To these recurrent assaults the Holy See invariably replied with a barrage of protests and denunciations which reverberated throughout the Catholic world. Each fresh crisis was accompanied by recriminations which threw into sharp relief the formidable barriers to an understanding between these seemingly irreconcilable foes.
Ambiguous elections: the influence of non-electoral politics in Ethiopian democratisation
Authors: Tronvoll Kjetil
Published: July 2009

The ‘non-electoral context’ of elections is often overlooked in democratisation studies, in order not to obscure an otherwise clear model or theory of transition. A key challenge for research on democratisation processes is to balance electoral ‘formalities’ with contextual factors, qualitative perceptions and non-electoral issues, in order to reach a more nuanced and comprehensive understanding of democratic transitions. This article advocates a multilayered approach to – or a ‘thick description’ of – elections, as this will capture the diversity of real life experiences and expose alternative power discourses competing with the electoralist one in influencing the path of democratisation. In so doing, it casts light on the crucial impact of the Eritrean–Ethiopian war on Ethiopia's 2005 election, in addition to other qualitative and contextual factors, which lead to the conclusion that the advancement of democracy through multiparty elections in Ethiopia under the Ethiopian Peoples' Revolutionary Democratic Front (EPRDF) has failed.
Temporal order memory deficits prior to clinical diagnosis in Huntington’s disease
Authors: PIROGOVSKY EVA , GOLDSTEIN JODY , PEAVY GUERRY , JACOBSON MARK W. , COREY-BLOOM JODY , GILBERT PAUL E.
Published: July 2009

The current study examined temporal order memory in preclinical Huntington’s disease (pre-HD). Participants were separated into less than 5 years (pre-HD near) and more than 5 years (pre-HD far) from estimated age of clinical diagnosis. Participants completed a temporal order memory task on a computerized radial eight-arm maze. On the study phase of each trial, participants viewed a random sequence of circles appearing one at a time at the end of each arm. On the choice phase, participants viewed two circles at the end of the study phase arms and chose the circle occurring earliest in the sequence. The task involved manipulations of the temporal lag, defined as the number of arms occurring in the sample phase sequence between the two choice phase arms. Research suggests that there is more interference for temporally proximal stimuli relative to temporally distal stimuli. There were no significant differences between the pre-HD far group and controls on the temporal order memory task. The pre-HD near group demonstrated significant impairments relative to the other groups on closer temporal lags, but were normal on the furthest temporal lag. Therefore, temporal order memory declines with increased temporal interference in pre-HD close to estimated diagnosis of HD. (JINS, 2009, 15, 662–670.)
Reversed ionospheric convections during the November 2004 storm: Impact on the upper atmosphere
Authors: Deng Yue , Lu Gang , Kwak Young‐Sil , Sutton Eric , Forbes Jeffrey , Solomon Stan
Published: July 2009

Using the Assimilative Mapping of Ionospheric Electrodynamics (AMIE) procedure, a particular period (2000–2350 UT on 9 November) in the November 2004 storm is studied. During this time interval, IMF Bz was strongly northward along with a high solar wind dynamic pressure, favorable conditions to form reversed convection in the polar region. Indeed, the AMIE outputs show strong reversed convection cells in both hemispheres for a long period (>1 h), which have rarely been observed. The impact on the thermospheric neutral wind has been investigated using the AMIE outputs as the electrodynamic inputs of the National Center for Atmospheric Research Thermosphere Ionosphere Electrodynamics General Circulation Model. After the ionospheric convection reversed, the neutral wind distribution at 400 km altitude changed correspondingly, and the difference wind patterns reversed in the polar cap region. By comparing the temporal variations of the difference ion convection and the difference neutral wind, it is found that horizontal neutral winds respond to the reversed convection with some time delay. The neutral wind response time (e‐folding time) clearly has an altitudinal dependence varying from 45 min at 400 km altitude to almost 1.5 h at 200 km. The vertical component vorticity has a similar magnitude and distribution to previous studies in the northward Bz condition and changes the sign when the convection pattern is reversed. Comparison between the CHAMP observed cross‐track wind and the simulated neutral wind exhibits a general agreement, and the temporal variations of CHAMP cross‐track wind indicate a strong effect of the ion drag force on neutral winds.
Transport of momentum and scalar in turbulent flows with anisotropic dispersive waves
Authors: Sukoriansky Semion , Dikovskaya Nadejda , Galperin Boris
Published: July 2009

Most geophysical flows encompass turbulence and internal and/or Rossby waves. We demonstrate that these two different classes of waves cause remarkably similar anomalies in the turbulent transport. While all scales in both types of flows contribute to the momentum diffusion, the vertical (diapycnal) scalar diffusion in stratified flows and lateral diffusion in β‐plane turbulence can be carried out only by turbulent eddies whose size is smaller than the thresholds of turbulence anisotropization. Beyond these thresholds, both flows become dominated by waves that provide no contribution to the scalar diffusion. Stably stratified flows exhibit enhanced isopycnal diffusion of both momentum and scalar. These results shed new light on the Osborn mixing model, diapycnal and isopycnal viscosity and diffusivity, absence of the critical gradient Richardson number, and large scale meridional transport.
Plasma membrane and nuclear envelope integrity during the blebbing stage of apoptosis: a time‐lapse study
Authors: Andrade Ricardo , Crisol Lorena , Prado Roberto , Boyano María Dolores , Arluzea Jon , Aréchaga Juan
Published: July 2009

Background information. The execution phase of apoptosis is characterized by extensive blebbing of the plasma membrane, which usually results in secondary lysis in vitro. To analyse the permeability of cellular membranes during this process, we induced apoptosis in human melanoma A375 cells that had been transfected with fluorescently tagged proteins which were targeted to different subcellular locations.

Results. The dual treatment of resveratrol and butyrate produced a synergistic induction of apoptosis by blocking different phases of the cell cycle. Changes in the plasma membrane, nuclear envelope and nucleoli were monitored by time‐lapse confocal microscopy. Fluorescently labelled proteins were not mis‐localized from their original locations in any of the cells undergoing blebbing for several hours. Thus the maintenance of karyophilic and nucleolar proteins within the nucleus during the blebbing stage and the accessibility of vital selective chromatin dyes confirmed a functional preservation of the nuclear compartment until the final necrotic blister. The translocation of phosphatidylserine to the outer leaflet of the plasma membrane was not detected during the blebbing period.

Conclusion. These results show that the functional integrity of the nuclear envelope and plasma membrane may be conserved until the end of the execution phase of apoptosis.
RNase R mutants elucidate the catalysis of structured RNA: RNA-binding domains select the RNAs targeted for degradation
Authors: Matos Rute Gonçalves , Barbas Ana , Arraiano Cecília Maria
Published: July 2009

The RNase II superfamily is a ubiquitous family of exoribonucleases that are essential for RNA metabolism. RNase II and RNase R degrade RNA in the 3′→5′ direction in a processive and sequence-independent manner. However, although RNase R is capable of degrading highly structured RNAs, the RNase II activity is impaired by the presence of secondary structures. RNase II and RNase R share structural properties and have a similar modular domain organization. The eukaryotic RNase II homologue, Rrp44/Dis3, is the catalytic subunit of the exosome, one of the most important protein complexes involved in the maintenance of the correct levels of cellular RNAs. In the present study, we constructed truncated RNase II and RNase R proteins and point mutants and characterized them regarding their exoribonucleolytic activity and RNA-binding ability. We report that Asp280 is crucial for RNase R activity without affecting RNA binding. When Tyr324 was changed to alanine, the final product changed from 2 to 5 nt in length, showing that this residue is responsible for setting the end-product. We have shown that the RNB domain of RNase II has catalytic activity. The most striking result is that the RNase R RNB domain itself degrades double-stranded substrates even in the absence of a 3′-overhang. Moreover, we have demonstrated for the first time that the substrate recognition of RNase R depends on the RNA-binding domains that target the degradation of RNAs that are ‘tagged’ by a 3′-tail. These results can have important implications for the study of poly(A)-dependent RNA degradation mechanisms.
Voltage-dependent anion channels 1 and 2 are expressed in porcine oocytes
Authors: Cassará María Carolina , Menzel Viviana Andrea , Hinsch Klaus-Dieter , Wrenzycki Christine , Hinsch Elvira
Published: July 2009

The eukaryotic VDAC (voltage-dependent anion channel) is a pore-forming protein originally discovered in the outer membrane of mitochondria. It has been established as a key player in mitochondrial metabolism and ion signalling. In addition, in recent years, it has also been proposed that VDAC is present in extra-mitochondrial membranes, and it has been related to cytoskeletal structures. However, little is known about the presence and intracellular localization of VDAC subtypes in mammalian gametes. In the present study, we confirm the synthesis of VDAC1 and 2 subtypes in GV (germinal vesicle) and MII (meiosis II) stage porcine oocytes as well as their protein expression. A shift in the abundance of immunoreactive 32 kDa VDAC protein between GV and MII stage oocytes was observed with anti-VDAC2 antibody. Furthermore, subcellular localization by confocal laser microscopy demonstrated fluorescent labelling of VDAC1 over the entire oocyte surface, suggesting the presence of VDAC1 in the porcine oocyte plasma membrane and around the cortical area. Anti-VDAC2 immunostaining yielded ring-like clusters of structures distributed on the cortical area in some GV, but not in MII, stage oocytes. These results are the first data obtained for VDAC in mammalian female gametes and provide the basis for studying protein–protein interactions, distribution and possible functions of VDAC subtypes during maturation and fertilization of mammalian oocytes.