bluuebunny/crossref_metadata_2025 huggingface dataset:
FLT3 inhibition upregulates OCT4/NANOG to promote proliferation and TKI resistance of FLT3-ITD+ acute myeloid leukemia
Authors: Zhou Qi , Shu Xiaojun , Zhao Pingping , Li Zijian , Chu Huiyuan , Guan Yongyu , Chai Yihong , Xi Yaming
Published: April 2024

Background: Up to 30% of acute myeloid leukemia (AML) patients face unfavorable outcomes due to the FMS-like receptor tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutation. Although FLT3 inhibitors show encouraging outcomes in treatment, they fail to eliminate leukemia stem cells, the origin of persistent and resistant lesions. Exploration of the mechanism in FLT3-ITD+ AML maintenance and chemoresistance is crutial for the development of novel therapeutic approaches. The manifestation of pluripotency transcription factors (TFs) and their link to clinical outcomes have been documented in various tumors. This study investigates the correlation between core pluripotency TF and treatment in AML.
Results: We discovered that FLT3 inhibition induced upregulation of OCT4 and NANOG in FLT3-ITD+ AML cells. Subsequently, we demonstrated that downregulation of OCT4 or NANOG inhibited cell growth, promoted apoptosis, and induced G0/G1 cell cycle phase arrest in FLT3-ITD+ AML cells. Importantly, downregulation of OCT4 or NANOG increased responsiveness to FLT3-tyrosine kinase inhibitor (TKI) (gilteritinib), implying that OCT4 and NANOG may contribute to TKI resistance in FLT3-ITD+AML.
Conclusion: Our study verifies the involvement of OCT4 and NANOG in regulating TKI sensitivity, and targeting them may improve the cytotoxicity of FLT3 TKIs in FLT3-ITD+ AML.
Prediction of Bending Angle of Ti6Al4V Alloy Sheets Formed Using Multiple Laser Irradiation
Authors: Mulay Sujit , Paliwal Vineet , Babu N. Ramesh
Published: April 2024

This study proposes a model to predict the bending angle of Ti6Al4V alloy sheets formed using multiple laser irradiation. The model uses the 1D heat transfer equation to calculate the temperature along the sheet thickness direction by considering the conductive losses. Based on this temperature, the thermal strains and stresses induced along the sheet's thickness are estimated. Finally, the bending angle of the sheet is calculated by balancing the strain energies induced by stress, strain, and the bending moment. For the subsequent irradiation, the temperature dependent properties of Ti6Al4V alloy were updated based on the initial temperature of sheet. The experimental and predicted bending angle results were compared for Ti6Al4V alloy sheets of varying thicknesses. The proposed model predicts the bending angle with an average percentage error of 8.86% for 2 mm thick Ti6Al4V alloy sheet.
Lived experiences of cancer patients undertaking chemotherapy at Felege-Hiwot Comprehensive Specialized Hospital, Bahir Dar, North-West Ethiopia, a descriptive phenomenological study
Authors: Yigzaw Zeamanuel Anteneh , Ambaw Fentie , Birhanu Belayneh
Published: April 2024

Background: Cancer is the most important cause of acute and chronic illnesses in the world. Cancer has different types of symptoms at different stages on different sites of the body. Chemotherapy involves different side complications and harsh effects on the patient’s general health in emotional, social, physical, and spiritual dimensions. Therefore, this study aimed to explore the lived experiences of patients living with cancer undertaking chemotherapy in Felege-Hiwot Comprehensive Specialized Hospital, Bahir Dar, North-west Ethiopia.
Method: A descriptive phenomenological study was conducted from March 17 to May 23, 2021. A heterogeneous purposive sampling technique was used to select the study participants. Thirteen cancer patients and two healthcare workers who work at the oncology center were enrolled. Data was gathered from patients undertaking chemotherapy through an in-depth interview guide and observational checklist. The data obtained through in-depth interviews and observation was recorded, transcribed translated, and coded by using Atlas Ti version 7 software. Thematic analysis was used. The rigor of the study was obtained.
Result: In this study, five main themes and thirteen subthemes were constructed. The major themes were: - the seriousness of the disease, affected usual role, financial constraint, psychological impact, and challenges to getting chemotherapy. The disease affects the participants by restricting their social movement. The inaccessibility of the service unit in their immediate surroundings, as well as a lack of drugs and lab investigations in the government hospitals, makes their lives difficult.
Conclusion: The study identified five main themes and thirteen subthemes. The participants explore the condition of the disease as an incurable disease and consider the disease to be deadly. The disease became serious due to the nature of the treatment and its side effects. The disease also prevents the patient and their family from participating in various activities. Therefore, we recommend accessible, affordable chemotherapy services with psychological support to all cancer patients.
Promoting Equity in Hepatitis C Care: A Qualitative Study Using an Intersectionality Lens to Explore Barriers and Facilitators to Point-of-Care Testing Among People Who Inject Drugs and Service Providers
Authors: Fontaine Guillaume , Presseau Justin , Bruneau Julie , Etherington Cole , Thomas Isabella M. , Hung Jui-Hsia Cleo , Allen Zack van , Patey Andrea M. , Kareem Ayesha , Mortazhejri Sameh , Høj Stine Bordier , Boyer-Legault Geneviève , Grimshaw Jeremy M.
Published: April 2024

Background: Hepatitis C virus (HCV) infection is a significant global health burden, particularly among people who inject drugs. Rapid point-of-care HCV testing has emerged as a promising approach to improve HCV detection and linkage to care in harm reduction organizations such as needle and syringe programs. The objective of this study was to use an intersectionality lens to explore the barriers and enablers to point-of-care HCV testing in a needle and syringe program.
Methods: A qualitative study was conducted using semi-structured interviews with clients (people who inject drugs) and service providers in a large community organization focused on the prevention of sexually transmitted and blood borne infections in Montreal, Canada. An intersectionality lens was used alongside the Theoretical Domains Framework to guide the formulation of research questions as well as data collection, analysis, and interpretation.
Results: We interviewed 27 participants (15 clients, 12 providers). The intersectional analysis revealed that intersectional stigma amplifies access, emotional and informational barriers to HCV care for people who inject drugs, while identity and lived experience of HCV and drug use represent powerful tools leveraged by providers. There were four themes for clients: (1) understanding and perceptions of HCV testing, (2) an accessible and inclusive environment for HCV testing, (3) the interplay of emotions and motivations in HCV testing decision-making, and (4) the impact of intersectional stigma related to HCV, behaviors (e.g., drug use), and identities (e.g., gender identity). For providers, five themes emerged: (1) knowledge, skills, and confidence for HCV testing, (2) professional roles and their intersection with identity and lived experience, (3) resources and integration of services, (4) social and emotional factors, and (5) behavioral regulation and incentives for HCV testing.
Conclusion: The application of an intersectionality lens provides a nuanced understanding of the impact of intersectional stigma in the lives of people who inject drugs, which amplifies barriers to point-of-care HCV testing. Findings underscore the need for tailored strategies that address stigma, improve provider roles and communication, and foster an inclusive environment for equitable HCV care. Integrating an intersectionality lens into implementation research offers valuable insights for more equitable and effective interventions.
Secukinumab’ Cardioprotective Effect in Doxorubicin-induced cardiomyopathy: Targeting the NF-κB/NLRP3 Pathway in Rats
Authors: Hassen Mostafa D. , Mousa Nahla O. , Radwan Sara M. , Gabre Refaat M.
Published: April 2024

Doxorubicin (DOX) is a medication employed in the treatment of cancer as a chemotherapeutic agent. However, it induces cardiotoxicity via activating inflammatory pathways. Cytokines dysregulation is a key factor that can lead to activation of inflammatory mechanisms. Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that triggers pathogenic immune responses. The objective of this study was to investigate the defensive power of secukinumab (SEC), a fully human monoclonal IgG1/κ antibody targeting IL-17A, designed to combat DOX-induced cardiotoxicity (DIC). Male Wistar rats were treated with DOX and co-treated with SEC for two weeks. The results showed that DOX caused heart tissue injury, increased cardiotoxicity markers significantly (P < 0.0001), oxidative stress and inflammation. Additionally, DOX activated the nuclear factor kappa beta (NF-κB) pathway and Pyrin domain containing 3 (NLRP3) inflammasome, potentially contributing to DIC. The co-treatment with SEC successfully reversed all DOX-related abnormalities by restoring cardiac functions to normal levels, decreasing levels of inflammatory cytokines, including IL-17A and Interleukin-1β (IL-1β), and improving oxidative stress by lowering malondialdhyde (MDA) levels and increasing reduced glutathione (GSH) levels. Furthermore, it also decreased the upregulation of the NF-κB/NLRP3 axis induced by doxorubicin. This study highlights the protective properties of SEC against DIC by modulating the NF-κB/NLRP3/caspase1/IL-1β axis.
Frailty trajectories preceding dementia: an individual-level analysis of four cohort studies in the United States and United Kingdom
Authors: Ward David , Flint Jonny , Littlejohns Thomas , Foote Isabelle , Canevelli Marco , Wallace Lindsay , Gordon Emily , Llewellyn David , Ranson Janice , Hubbard Ruth , Rockwood Kenneth , Stolz Erwin
Published: April 2024

Frailty may represent a modifiable risk factor for dementia, but the direction of that association remains uncertain. We investigated frailty trajectories in the years preceding dementia onset using data from 23,672 participants (242,760 person-years of follow-up, 2,906 cases of incident dementia) across four cohort studies in the United States and United Kingdom. Bayesian non-linear models revealed accelerations in frailty trajectories 4–9 years before incident dementia. Among participants whose time between frailty measurement and incident dementia exceeded that prodromal period, frailty remained positively associated with dementia risk (adjusted hazard ratios ranged from 1.20 [95% confidence interval, CI = 1.15–1.26] to 1.43 [95% CI = 1.14–1.81]). This observational evidence suggests that frailty increases dementia risk independently of any reverse causality. These findings indicate that frailty measurements can be used to identify high-risk population groups for preferential enrolment into clinical trials for dementia prevention and treatment. Frailty itself may represent a useful upstream target for behavioural and societal approaches to dementia prevention.
Baseflow Separation for Improving Dam Inflow Prediction using Data-Driven Models
Authors: Han Heechan , Park Heeseung , kim donghyun
Published: April 2024

Improving the accuracy of rainfall-runoff simulations is an important challenge for efficient water resource management. Data-driven models are alternatives for simulating and predicting streamflows based on the relationships between meteorological variables and runoff. To improve runoff forecasting performance, we present data-driven model-based runoff forecasting algorithms coupled with a baseflow separation process. For the evaluation, we used two types of data-driven algorithms, deep neural network (DNN) and random forest (RF), and considered the historical patterns of precipitation, air temperature, humidity, and dam inflows as input data for the algorithms. In addition, we evaluated the prediction model by applying lead times of 1–7 days to construct the optimal input datasets. The performance of the dam inflow prediction using data-driven models coupled with the baseflow separation process was better than that of the algorithm without the process.
Are there interindividual differences in the reactive hypoglycaemia response to breakfast? A replicate crossover trial
Authors: Gonzalez Javier T. , Lolli Lorenzo , Veasey Rachel C. , Rumbold Penny L.S. , Betts James A. , Stevenson Emma J. , Atkinson Greg
Published: April 2024

Background
Following consumption of a meal, circulating glucose concentrations can rise and then fall briefly below the basal/fasting concentrations. This phenomenon is known as reactive hypoglycaemia but to date no study explored potential inter-individual differences in response to meal consumption.
Objective
We conducted a secondary analysis of existing data to examine inter-individual variability of reactive hypoglycaemia in response to breakfast consumption.
Methods
Using a replicate crossover design, 12 healthy men completed two identical control (continued overnight fasting) and two breakfast (444 kcal) conditions in randomised sequences. Blood glucose and lactate concentrations, serum insulin and non-esterified fatty acid concentrations, whole-body energy expenditure, carbohydrate and fat oxidation rates, and appetite ratings were determined before and 2 hours after the interventions. Inter-individual differences were explored using Pearson’s product-moment correlations between the first and second replicates of the control-adjusted breakfast response. Within-participant covariate-adjusted linear mixed models and a random-effects meta-analytical approach were used to quantify participant-by-condition interactions.
Results
Breakfast consumption lowered 2-h blood glucose 0.44 mmol/L (95%CI: 0.76 to 0.12 mmol/L) and serum NEFA concentrations, whilst increasing blood lactate and serum insulin concentrations (all p < 0.01). Large, positive correlations were observed between the first and second replicates of the control-adjusted insulin, lactate, hunger, and satisfaction responses to breakfast consumption (all r > 0.5, 90%CI ranged from 0.03 to 0.91). The participant-by-condition interaction response variability (SD) for serum insulin concentration was 11 pmol/L (95%CI: 5 to 16 pmol/L), which was consistent with the τ-statistic from the random-effects meta-analysis (11.7 pmol/L, 95%CI 7.0 to 22.2 pmol/L) whereas effects were unclear for other outcome variables (e.g., τ-statistic value for glucose: 0 mmol/L, 95%CI 0.0 to 0.5 mmol/L).
Conclusions
Despite observing reactive hypoglycaemia at the group level, we were unable to detect any meaningful inter-individual variability of the reactive hypoglycaemia response to breakfast. There was, however, evidence that 2-h insulin responses to breakfast display meaningful inter-individual variability, which may be explained by relative carbohydrate dose ingested and variation in insulin sensitivity of participants.
Genome-wide identification, structural characterization and expression profiling of AP2/ERF gene family in bayberry (Myrica rubra)
Authors: Liu Yumeng , Cai Linqi , Zhu Jiali , Lin Yue , Chen Minghui , Zhang Huiling , Fan Xiurun , Xu Kai , Wu Boping
Published: April 2024

Background: Bayberry is the most economically significant fruit within the Myricaceae family, having high nutritional and medicinal value. The AP2/ERF family is a class of transcription factors found mainly in plants. However, the bayberry AP2/ERF gene family has not previously been studied.
Results: In this study, 113 members of the bayberry AP2/ERF gene family were identified. According to the phylogenetic tree, the members of this group are divided into three subfamilies. The gene structure and conserved motifs were analyzed. Chromosome localization showed that 95 genes were unevenly distributed on 8 chromosomes and 18 genes were located on the skeleton. In addition, we further investigated the collinearity between these genes and related genes in six other species. Transcriptomic data showed that the expression pattern of AP2/ERFgene was different in bayberry space electric field treatment and at different stages of development.
Conclusions: The AP2/ERFgene was identified in the genome of bayberry, and its structure, conserved motif, and phylogenetic relationship were analyzed. These findings of this study serve as a reference for the genome-wide identification of the AP2/ERFgene family in other species and groundwork for future research on the function of AP2/ERF genes in bayberry.
Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β
Authors: De Groof Timo W.M. , Lauwers Yoline , De Pauw Tessa , Saxena Mohit , Vincke Cécile , Craenenbroeck Jolien Van , Chapon Catherine , Grand Roger Le , Raes Geert , Naninck Thibaut , Ginderachter Jo A. Van , Devoogdt Nick
Published: April 2024

Purpose
While immunotherapy has revolutionized the oncology field, variations in therapy responsiveness limit the broad applicability of these therapies. Diagnostic imaging of immune cell, and specifically CD8+ T cell, dynamics could allow early patient stratification and result in improved therapy efficacy and safety. In this study, we report the development of a nanobody-based immunotracer for non-invasive SPECT and PET imaging of human CD8+ T-cell dynamics.
Methods
Nanobodies targeting human CD8β were generated via llama immunizations and subsequent biopanning. The lead anti-human CD8β nanobody was characterized in vitro on binding, specificity, stability and toxicity. The lead nanobody was labelled with 99mTc and 68Ga for non-invasive imaging of human T-cell lymphomas and CD8+ T cells in human CD8 transgenic mice and non-human primates via SPECT or PET/CT. Repeated imaging of CD8+ T cells in MC38 tumor-bearing mice was performed to visualize CD8+ T-cell dynamics.
Results
The nanobody-based immunotracer showed high affinity and specific binding to human CD8 without unwanted immune activation. CD8+ T cells were non-invasively visualized via SPECT and PET imaging in naïve and tumor-bearing mice and in naïve non-human primates with high sensitivity. The nanobody-based immunotracer showed enhanced specificity for CD8+ T cells and/or faster in vivo pharmacokinetics compared to previous human CD8-targeting immunotracers, allowing us to follow human CD8+ T-cell dynamics already at early timepoints.
Conclusion
Overall, this study describes the development of a more specific human CD8+ T-cell-targeting immunotracer, allowing follow up of immunotherapy responses via non-invasive imaging of human CD8+ T-cell dynamics.
Bovine Tuberculosis in Central Ethiopian Slaughterhouses and Identification of Causative Mycobacteria by Multiplex Real-Time PCR
Authors: Fromsa Abebe , Zeleke Yemisrach , Sriniva Sreenidhi , Gumi Balako , Lakew Matios , Abdela Musse , Bahiru Getahun , Worku Dawit , Vordermeier H. Martin , Bakker Douwe , Berg Stefan , Ameni Gobena , Wood James , Conlan Andrew , Kapur Vivek
Published: April 2024

Background
Bovine tuberculosis (bTB) is a chronic disease primarily caused by Mycobacterium bovis that ultimately leads to the development of progressive granulomatous lesions. Although the disease is widespread, especially on intensive dairy farms in Ethiopia, routine investigations and surveillance are lacking. Thus, the aim of this study was to determine the prevalence, associated risk factors, and species of mycobacteria causing bTB in slaughtered cattle at four slaughterhouses in Central Ethiopia.
Methods
Postmortem examination of 7,640 cattle was conducted using a cross-sectional slaughterhouse survey. A total of 388 tuberculous-like lesions (TBLs) were collected from 173 animals and cultured. Six target genes were used to differentiate mycobacterial species using multiplex real-time PCR (mRT-PCR). Multivariate logistic regression analyses and related odds ratios (ORs) were used to gauge the strength of the associations between risk factors, TBL incidence and culture growth.
Results
The prevalence of TBL was 2.3% (95% CI = 2.0-2.6). Logistic regression analysis indicated an increased risk of TBL in crossbred cattle (OR = 11.0, 95% CI: 6.1, 19.8). Animals slaughtered at Adama (OR = 2.99, 95% CI: 1.25, 7.14) or Burayu (OR = 5.65, 95% CI: 3.76, 8.47) had a greater risk of TBL than those slaughtered at Sululta. There were significantly more TBL-positive lesions in the lungs and lymph nodes related to the lung (OR = 6.35; 95% CI: 2.46, 16.4) and the head lymph node (OR = 3.05; 95% CI: 1.05, 8.93). Among the 173 TBL-positive animals, 36% (95% CI = 28.8, 43.2) were culture positive, and among the 388 TBL-positive tissues, 24.2% (95% CI = 20, 29) were culture positive. All the culture-generated isolates were M. bovis positive according to mRT-PCR, suggesting persistent transmission among the cattle population, posing a serious public health threat.
Conclusion
This study revealed an eleven-fold greater risk of bTB-related lesions in crossbred cattle than in local zebu cattle. This finding highlights the necessity for targeted interventions, continuous vigilance, and thorough meat inspection to mitigate public health risks.
Cognitive Flexibility and Emotion Regulation in Eating Disorder Patients with Comorbid Generalized Anxiety and Posttraumatic Stress Symptoms
Authors: Thompson Connor J , Martin-Wagar Caitlin A
Published: April 2024

Research has found that difficulties in emotion regulation negatively impact mental health, whereas cognitive flexibility may promote stress resilience and positive mental health. Little is known about cognitive flexibility and emotion regulation in people with comorbid eating disorder (ED) and anxiety and stress disorders. A transdiagnostic ED population (N = 227) at an outpatient ED treatment facility completed several self-report instruments that measured cognitive flexibility, emotion regulation difficulties, posttraumatic stress disorder (PTSD) symptoms, and generalized anxiety disorder (GAD) symptoms upon admission. We investigated cognitive flexibility and emotion regulation differences for those with an ED without comorbidity and those with various combinations of comorbidity. In a one-way between-groups ANOVA, we investigated differences in cognitive flexibility for those with GAD, PTSD, neither, and both comorbidities. We found a statistically significant difference between these groups, with mean cognitive flexibility inventory scores being the lowest in the group with both comorbidities. However, when controlling for emotion regulation, a one-way between-groups ANCOVA indicated no significant differences in cognitive flexibility between comorbidity groups F(3, 222) = 1.20, p = .31 Partial η2 = .02. Though self-reported cognitive flexibility levels differ among ED patients with and without comorbidities, it appears that these differences are better explained by emotion regulation. Therefore, addressing emotion regulation early in treatment for all individuals with EDs, regardless of comorbidity. Further research is needed to understand the impact of treating emotion regulation on ED treatment engagement, dropout, and effectiveness.
Automated Segmentation of Intracranial Carotid Atherosclerosis in Histological Images: Assessing the Effect of Staining
Authors: Reimer Michal , Dvorský Ondřej , Szabó Zoltán , Klempíř Ondřej , Mandys Václav , Školoudík David , Kybic Jan , Krupička Radim
Published: April 2024

Atherosclerosis, a major cause of ischemic stroke worldwide, is characterized by plaque formation, particularly in the carotid bifurcation, leading to arterial stenosis. Traditional histology and light microscopy have been used to study atherosclerotic plaques, but the advent of digital pathology and artificial intelligence provides new opportunities. In this work, we propose an automatic segmentation method using convolutional neural networks (U-Net and DeepLabV3+) to delineate atherosclerotic carotid plaque tissue. The study includes 835 images of histological slices stained with hematoxylin and eosin and Van Gieson's method from 114 patients. The results show that DeepLabV3 + outperforms U-Net, achieving high accuracy for tissue types such as lumen, fibrous tissue, atheroma, calcification, and hemorrhage. Staining influences segmentation results, with Van Gieson's stain excelling in fibrous tissue segmentation, while hematoxylin and eosin show better results for calcification and hemorrhage. Moreover, the segmentation models facilitate clinical plaque classification, demonstrating good discrimination performance. Our study highlights the potential of deep neural networks in segmenting atherosclerotic plaques, while emphasizing the need for careful consideration of staining effects in computerized analysis.
Agricultural intensification affects communities of plants and arthropods in field borders and their potential to engender biological control
Authors: Saldanha Alan V. , Carvalho Rayana M.R. , Machado Carolina F.M. , Souza João Paulo , Gontijo Lessando M.
Published: April 2024

In agriculture, spontaneous field border vegetation can engender several benefits, including mitigating soil erosion, increasing carbon retention, conserving pollinators, and promoting biological control. The extension of these benefits can, however, often depend on the context of location and time. As for biological control, field borders can promote natural enemy conservation if the plants therein can provide adequate resources (e.g. shelter, alternative food, microclimate). In the context of location, field borders can be adjacent to areas with varying degrees of agricultural intensification, including fields with annual crops, perennial crops, or forest areas. While many studies have investigated how field borders can influence arthropod communities in adjacent crops, the opposite direction of effect (i.e. how crop areas can influence adjacent field borders) remains an underexplored topic. Therefore, in this three-season study we selected vegetated field borders next to annual crops, perennial crops, and forest areas, to study their communities of spontaneous plants (weeds) and arthropods as well as their potential to engender biological control. In general, our results show that the community composition of plants and arthropods was affected by land use type and season. Furthermore, field border vegetation next to areas with higher level of agricultural intensification (i.e. annual or perennial crops) harbored more herbivores, flowers and natural enemies; although some of these results were season dependent. Lastly, field borders next to annual or perennial crop areas engendered stronger biological control of aphids; possibly due to the alternative food (herbivores/aphids and flowers) provided by the plants therein. Taken altogether, our results reinforce the importance of preserving spontaneous field border vegetation, especially in areas under intensive agriculture management.
Die Entwicklung der Rechtschreibleistungen in der DDR und deren Bewertung: eine Untersuchung anhand von Abituraufsätzen (1949–1989)
Authors: Von Brand Tilman , Hübner Roberto , Koch Katja , Koebe Kristina
Published: April 2024

In diesem Beitrag wird anhand der Teilnote Rechtschreibung/Grammatik untersucht, wie sich die Rechtschreib- und Grammatikleistungen von Abiturient*innen in der DDR entwickelt haben. Analysiert werden N=1995 Abituraufsätze aus den Schuljahren 1957/58–1988/89 aus einem neu erschlossenen, unikalen Korpus, das aus zwei Teildatensätzen unterschiedlicher Regionen besteht. Die Ergebnisse zeigen eine kontinuierliche Verbesserung der Noten ebenso wie ein kontinuierliches Absinken der Anzahl von Fehlern. An einer Stichprobe von N=50 Aufsätzen wird zudem detailliert die Qualität der Leistungsauswertung sowie der Leistungsbeurteilung durch die Lehrer*innen analysiert. Im Anschluss wird anhand von Thesen diskutiert, worauf die Leistungsverbesserungen möglicherweise zurückzuführen sind und welche Rolle die Beurteilungsqualität der Lehrer*innen spielt.
Bericht über das Colloquium „Sprachlichkeit und Fachlichkeit in ihrem Zusammenspiel für fachliche Lernprozesse
Authors: Hülsmann Delia , Hesse Florian
Published: April 2024

Der Beitrag berichtet von dem Colloquium „Sprachlichkeit und Fachlichkeit in ihrem Zusammenspiel für fachliche Lernprozesse“, das vom 4. bis 5. März 2024 an der Universität zu Köln stattfand. Ziel des interdisziplinären Colloquiums unter Beteiligung verschiedener Fachdidaktiken war es, anhand theoretischer Modellierungen und empirischer Rekonstruktionen die Art und Richtung des Zusammenspiels von Sprachlichkeit und Fachlichkeit im Rahmen fachlicher Lehr-Lern-Prozesse auszuloten. Im Beitrag werden Anlage und Befunde der verschiedenen Vorträge gebündelt sowie zentrale Diskussionsfragen skizziert, die für zukünftige Forschungen in diesem Bereich richtungsweisend sein können.
Johann Christoph Gottsched, 1700–1766
Authors: Schreiber Michael
Published: April 2024

"Es wäre zu wünschen, daß sich Herr Gottsched niemals mit dem Theater vermengt hätte […]. Er verstand ein wenig Französisch und fing an zu übersetzen; er ermunterte alles, was reimen und 'Oui Monsieur' verstehen konnte, gleichfalls zu übersetzen." Diese vernichtende Kritik Lessings von 1759 beeinflusst bis heute das Urteil über den einstigen "Literaturpapst" Gottsched in deutschen Literaturgeschichten. Das kann aber kein Hindernis sein, um für eine Geschichte des Übersetzens Gottscheds Verdienste als Verfasser, Herausgeber und Förderer von Übersetzungen (insbesondere aus der französischen Literatur der Aufklärung) genauer in den Blick zu nehmen.
The Impact of Parent-adult Child Bonding on Intention to Donate Real Estate Assets
Authors:   Korea Urban & Real Estate Association, Seo Seung-Hee , Choi Min-Seob
Published: April 2024

The purpose of this study is to derive the effect of the degree of solidarity between parents and adult children on the intention to donate real estate assets and suggest implications. First, it was found that the contact bond between parents and adult children did not affect the intention to donate real estate assets. Second, the functional bond between parents and adult children was found to affect the intention to donate real estate assets. Third, the unity between parents and adult children was found to affect the intention to donate real estate assets. Fourth, the affectional bond between parents and adult children was found to have no effect on the intention to donate real estate assets. Lastly, the normative bond between parents and adult children was found to affect the intention to donate real estate assets.
Desafios socioeconômicos no turismo do pantanal mato-grossense
Authors: Ribeiro Magno Alves , Alcântara Liliane Cristine Schlemer , Sampaio Carlos Alberto Cioce
Published: April 2024

O setor do turismo foi impactado significativamente nos períodos mais graves da pandemia da Covid-19. Não diferente, o turismo no Pantanal também foi afetado, ainda mais com o agravante dos incêndios nos períodos secos, que coincidem com a alta temporada local. O objetivo da pesquisa foi analisar os impactos socioeconômicos da pandemia de Covid-19 e das queimadas na vida dos atores sociais do turismo no município de Poconé, localizado no estado de Mato Grosso, com destaque para as pousadas rurais. A metodologia apresenta uma abordagem caracterizada como qualitativa e descritiva. Como técnicas de pesquisa, foram utilizadas pesquisas bibliográficas e análise documental dos dados secundários, além de entrevistas semiestruturadas com os proprietários das pousadas rurais. A pandemia e os incêndios em 2020 contribuíram para o fechamento de empresas, demissões de pessoas e consequente redução na arrecadação tributária. Nos meses finais do ano de 2021, em paralelo ao início da vacinação e à redução das mortes, os dados econômicos do setor apresentaram uma tendência positiva de recuperação nos aspectos socioeconômicos da região, tendência essa que foi mantida em 2022, conforme retratado pela retomada da visitação por turistas internacionais e nacionais.
Natural resources can help reducing cardiovascular risk: randomized controlled study
Authors: Rapolienė Lolita , Taletavičienė Giedrė , Martinkėnas Arvydas
Published: April 2024

Cardiovascular diseases are the leading cause of death globally accounting for 32 % of all global deaths. Addressing modifiable risk factors, including hypertension and stress, remains paramount in the prevention of CVD. This study aimed to assess the impact of the balneotherapy on blood pressure, heart rate, electrocardiogram parameters, utilization of antihypertensive medications, and stress levels. Methodology. Multicenter randomized controlled single-blind parallel group trial was made in 6 Lithuania resort centers. 373 participants with the stress level > 3 (10, VAS) randomly divided into 6 groups in two clusters for receiving a 6- or 11-day complex treatment using natural resources – mineral waters, peloids, salt, nature therapy; follow-up period was 6 months. The BP, HR, ECG, stress level and other parameters were analyzed in 131 participants who passed a full course of investigation. Results. The significant reduction of systolic blood pressure after treatment (7.8 mmHg) and during 6 months (7.3 mmHg) together with diastolic 5.5 after 6 month and heart rate (4 b/min) was achieved in 11-day ambulatory balneotherapy group. Increase in the activity of the parasympathetic nervous system was observed, which is reflected by an increase in the duration of the ECG indicators. The stress level decreased by up to 43%, and stress management improved by up to 41% following inpatient treatment. Conclusion. Therapy using natural resources could stand for additional cardiovascular disease prevention and management method in integrative therapy.
Analysis of a bus vertical dynamic performances – a comparison between linear and nonlinear suspension systems
Authors: Tran Huu Nhan , Pham Ngoc Dai
Published: April 2024

This paper mainly focuses on the numerical calculation to determine the vertical evaluation indexes with all three types of typical harmonic, transient and random road excitations. The effects of linear and nonlinear suspension characteristics on the vertical evaluation indexes are fully understood systematically. The ride comfort, suspension working space, and road holding are analyzed for both two cases of linear and nonlinear suspension systems. The improvement of the vertical stability and road holding in the case of nonlinear suspension subjected under three different excitations could be characterized most meaningfully. The obtained results help to systematically get full understanding of the investigated problem nature. It also should guide interested readers in suspension design to improve the stability, safety, and ride comfort of buses.
Recognizing Total Anomalous Pulmonary Venous Drainage (TAPVD) from Natural History to the Supportive Imaging Modalities
Authors: Caesario Fahreza , Putri Valerinna Yogibuana Swastika
Published: April 2024

Congenital Heart Disease (CHD) prevalence was 8 until 9 for each thousand live births, and among all of the CHD, there is in one of condition that involved the malformation of the venous system that called Total Anomalous Pulmonary Venous Drainage (TAPVD). TAPVD can be found and to be diagnosed in all ages, not only in the childhood era. Adult individuals with TAPVD are susceptible to being misdiagnosed as having a significant secundum atrial septal defect if the condition is not known or suspected. A systematic history taking, physical examination, and another supportive imaging modalities is needed to ensure this structural anomaly. Keyword: Congenital Heart Disease, TAPVD, Venous System Anomalies.
Echocardiographic Features in Patient Rheumatic Mitral Stenosis
Authors: Dwigustiningrum Nur Kaputrin , Rahimah Anna Fuji , Karolina Wella , Martini Heny
Published: April 2024

Rheumatic mitral stenosis (RMS) is a progressive valvular heart disease that can lead to significant morbidity and mortality, especially in developing countries. Echocardiography plays a crucial role in the diagnosis, assessment, and management of patients with RMS. This study aims to review the utility echocardiography feature in patient RMS. We discuss the key echocardiographic parameters used for assessment and severity of RMS, and associated valvular abnormalities. Additionally, we explore the role of multimodality imaging, such as transesophageal echocardiography in enhancing the diagnostic accuracy and therapeutic decision-making in RMS. A thorough understanding of echocardiographic findings in RMS is essential for clinicians involved in the care of these patients, as it aids in risk stratification, treatment planning, and monitoring of disease progression. Integrating echocardiography is a widely used non-invasive method for comprehensive assessment, monitoring disease progression and evaluating treatment efficacy, ensuring optimal management for patient with RMS. Keyword: Echocardiography, Rheumatic Heart Disease, Mitral Stenosis.
Because no one wants to die alone: Relationship initiation and dissolution behaviors associated with the fear of being single
Authors: Welling Lisa L. M. , Shephard Kayla
Published: April 2024

Here we replicate previous work on the fear of being single (FBS), personality, attachment, and relationship-contingent self-esteem, and also examine whether those with high FBS attempt to initiate romantic relationships more frequently and are more motivated by continued romantic attraction to remain friends with ex-partners than others. In line with prior work, FBS was positively associated with anxious attachment, relationship-contingent self-esteem, and emotionality. FBS was negatively associated with relationship initiation behaviors. Similarly, single men were more likely to attempt to initiate a romantic relationship with an opposite-sex friend than were single women, particularly if they were low in FBS. Although FBS was not associated with whether or not an individual remains friends with ex-partners, there was an association between FBS and continued romantic attraction as a motivator behind these friendships.
Diffusion and innovation belajar.id account: A systematic literature review
Authors: Atikasari Nur , Sunardi Sunardi
Published: April 2024

Learning during the COVID-19 pandemic has conditions educators and students cannot meet face to face, so online learning is carried out. The Ministry of Education and Culture 2020 launched a learning innovation, namely a belajar.id account to facilitate online learning. The diffusion process is essential for innovative products because it can affect the adoption rate of innovation. However, in the period of launch to date, it has yet to be discovered the process of diffusion of belajar.id accounts and the factors involved. This study aims to identify the diffusion process of innovation belajar.id account. This study used a systematic literature review research method using Google Scholar and Sinta databases. Based on 19 selected articles, this study identifies the diffusion process of innovation belajar.id account is influenced by innovation characteristics, communication channels, specific periods, and members of the social system. The factors involved consist of driving factors and inhibiting factors of innovation diffusion. Based on the research results and conclusions, this research can be a source of reference in carrying out learning innovations in education and developing existing learning innovations. Difusi dan inovasi akun belajar.id: Studi literaturPembelajaran saat pandemi covid-19 memiliki kondisi bahwa pendidik dan peserta didik tidak dapat bertatap muka secara langsung sehingga dilaksanakan pembelajaran secara online. Kementerian Pendidikan dan Kebudayaan pada tahun 2020 meluncurkan inovasi pembelajaran yaitu akun belajar.id untuk memfasilitasi pembelajaran online. Proses difusi sangat penting bagi produk inovasi karena dapat mempengaruhi tingkat adopsi inovasi. Namun, dalam kurun waktu peluncuran sampai saat ini, belum diketahui proses difusi akun belajar.id dan faktor-faktor yang terlibat. Tujuan penelitian ini untuk mengidentifikasi proses difusi inovasi akun belajar.id. Penelitian ini menggunakan metode penelitian systematic literature review. Dengan menggunakan basis data Google Scholar dan Sinta. Berdasarkan 19 artikel terpilih, penelitian ini mengidentifikasi proses difusi inovasi akun belajar.id dipengaruhi oleh karakteristik inovasi, saluran komunikasi, jangka waktu tertentu, dan anggota sistem sosial. Faktor yang terlibat terdiri dari faktor pendorong dan faktor penghambat difusi inovasi. Berdasarkan hasil penelitian dan kesimpulan, diharapkan penelitian ini dapat menjadi sumber referensi dalam melakukan inovasi pembelajaran di bidang pendidikan dan pengembangan inovasi pembelajaran yang sudah ada.
Pelatihan Daur Ulang Sampah Plastik Menjadi Ecopaving Bagi UKK Pemulung Desa Tublopo Kabupaten Timor Tengah Utara
Authors: Adu Risna Erni Yati , Gelyaman Gebhardus Djugian , Batu Matius Stefanus , Benu Didi Prasetyo
Published: April 2024

Pengelolaan sampah plastik di kawasan Hutan Tatub Desa Tublopo Kabupaten Timor Tengah Utara (TTU) masih dilakukan secara terbatas oleh Kelompok UKK Pemulung Desa Tublopo. Hal ini menyebabkan terjadinya penumpukan sampah plastic yang berakibat pada penyempitan lahan di Pos UKK dan juga di area pembuangan sampah sehingga sebagian sampah plastic di area pembuangan harus dibakar. Kondisi ini menjadi dasar dilakukannya kegiatan pengabdian sebagai salah satu upaya peningkatan pengetahuan dan keterampilan kelompok UKK Pemulung melalui kegiatan sosialisasi dan pelatihan outclass tentang manajemen akhir sampah plastic dan pelatihan pengolahan sampah plastic menjadi produk paving block. Tahapan kegiatan yang dilakukan untuk menyelesaikan persoalan mitra yaitu kegiatan persiapan, sosialisasi dan pelatihan serta evaluasi. Dari kegiatan yang telah dilakukan dapat disimpulkan bahwa pengetahuan anggota Kelompok UKK Pemulung Desa Tublopo tentang manajemen akhir sampah plastic dimulai dari pewadahan, pengumpulan, dan pemrosesan akhir telah mengalami peningkatan. Anggota UKK Pemulung sampah juga terampil dalam memilah dan mengolah sampah plastik menjadi produk paving block.
WORKSHOP STEM-ECO PRINTING UNTUK MENGEMBANGKAN JIWA ENTERPRENEURSHIP SISWA SEKOLAH MENENGAH KEBANGSAAN TENGKU PANGLIMA PERANG TENGKU MUHAMMAD, PAHANG, MALAYSIA
Authors: Wiyarsi Antuni , Azmi Nur Sabrina Ahmad , Yunus Muhamad Fahmi , Anazifa Rizqa Devi , Ariyanti Nur Aeni
Published: April 2024

Implementasi kurikulum berbasis STEM di Malaysia telah dilaksanakan sejak tahun 2017. Lamanya pengalaman tidak membuat implementasinya menjadi lebih mudah. Tantangan dan perkembangan teknologi menjadikan implementasi pembelajaran berbasis STEM menjadi lebih menantang. Variasi pembelajaran agar dapat mencakup baik dari segi science, technology, engineering dan mathematics-nya adalah salah satu tantangan yang dihadapi. Eco-printing merupakan metode pewarnaan dengan memanfaatkan pewarna alami. Dalam implementasinya teknik ini memiliki seluruh aspek dalam pembelajaran STEM. Hasil yang diperoleh juga memiliki nilai jual yang tinggi. Dengan adanya perkembangan pemanfaatan media social, diharapkan siswa juga dapat mengambil keuntungan di dalamnya. Oleh sebab itu kegiatan ini bertujuan untuk memberikan alternatif implementasi konsep STEM dalam pembelajaran di sekolah sekaligus menumbuhkan jiwa wira usaha sebagai muara pembelajaran berbasis STEM. Metode yang digunakan adalah workshop dengan pemberian materi dan praktik langsung. Kegiatan workshop STEM eco-printing dalam kerangka implementasi kurikulum berbasis STEM dan dikaitkan dengan pendidikan kewirausahaan telah memberikan alternatif implementasi kurikulum berbasis STEM yang mengasyikkan dan bernilai ekonomi dengan tetap pengedepankan basic science yang menjadi pondasi utamanya.
Cultural shocks: understanding the impact on international students' academic journey at Yogyakarta, Indonesia
Authors: Ahmed Touheed , Shahzeb Shahzeb
Published: April 2024

This study explores the experiences of international students who face cultural shock when starting higher education in Indonesia. Cultural shock manifests itself in a variety of ways, including changes in food, societal norms, behaviour, language, and religion, which cause students to experience stress, anxiety, and depression. The study investigates the coping mechanisms of the students, which include maintaining communication with locals, friends and family, engaging with Indonesian peers and immersing themselves in local culture. Despite initial difficulties, students gradually adjust to their new academic environment, aided by language proficiency, supportive university communities, and cultural assimilation within the curriculum. The findings emphasise the importance of predeparture education in terms of study programmes and their global implications, as well as fostering receptivity to diverse cultures and understanding cultural differences in order to facilitate effective adaptation and academic success abroad. Limitations include the subjective nature of experiences and the need for further investigation of specific cultural adaptation strategies. The recommendations include providing comprehensive support services for international students and incorporating cultural education into academic curricula.
The relationship of father's knowledge and support as a breastfeeding father on exclusive breastfeeding in the working area of Public Health Center Batanghari Hospital East Lampung
Authors: Kusumaningsih Meilia Rahmawati , Jannah Muliatul , Yulvina Vera
Published: April 2024

Background: Exclusive breastfeeding coverage in Lampung Province in 2020 was 70.1%, yet it still did not meet the expected target. Many factors influenced the success of exclusive breastfeeding. In providing breast milk, the father played a major role for the success. Father's knowledge and support in breastfeeding issues were the first thing the fathers needed to have to support breastfeeding practices. The fathers' support for the breastfeeding process was still lacking as society believed that breastfeeding was only the mother's duty. The support that a father could provide as a Breastfeeding Father could be in the form of helping with child care, helping with household chores, and providing food or other needs related to the breastfeeding process. Preliminary studies showed a lack of support from fathers for breastfeeding mothers at the Batanghari Lampung Community Health Center

Objective: The purpose of this study was to determine the relationship between the knowledge and the father's support as a breastfeeding father towards exclusive breastfeeding.

Method: This research was conducted in the Work Area of the Batanghari Inpatient Health Center, East Lampung in January - February 2023. The sample used was the fathers of infants aged 6-12 months in the Work Area of the Batanghari Inpatient Health Center, East Lampung, as many as 63 respondents obtained using accidental sampling technique . This research was a quantitative study using the Cross Sectional Study approach, analyzed by using the chi square test (α=0.05) for bivariate analysis.

Results: The results of this study indicates that there was a real relationship between the father's knowledge as a breastfeeding father and the father's support as a breastfeeding father on exclusive breastfeeding in the Work Area of the Batanghari Inpatient Health Center, East Lampung with p-values of 0.038 and 0.010.

Conclusions: There is a significant relationship between father's knowledge and the father's support as a breastfeeding father and exclusive breastfeeding in the Batanghari Inpatient Health Center, East Lampung working area.