bluuebunny/crossref_metadata_2025 huggingface dataset:
The Psychologist’s Green Thumb
Authors: Crüwell Sophia
Published: September 2023

The “psychologist’s green thumb” refers to the argument that an experimenter needs an indeterminate set of skills to successfully replicate an effect. This argument is sometimes invoked by psychological researchers to explain away failures of independent replication attempts of their work. In this article, I assess the psychologist’s green thumb as a candidate explanation for individual replication failure and argue that it is potentially costly for psychology as a field. I also present other, more likely reasons for these replication failures. I conclude that appealing to a psychologist’s green thumb is not a convincing explanation for replication failure.
Affective polarization and coalition signals
Authors: Wagner Markus , Praprotnik Katrin
Published: September 2023

Affective polarization between partisans is potentially troubling for liberal democracy. Hence, recent research has focused on how affective dislike between partisans can be reduced. Using a survey experiment in Austria, we test whether elite signals matter. Respondents exposed to fictional news stories implying that their in-party might form a coalition with an out-party show reduced dislike toward supporters of that out-party. Our experiment also shows that coalition signals can influence out-party affect even if neither of the two parties signaling cooperation are an in-party. We conclude that cooperation between rivals has an important role in reducing affective polarization.
Genome-wide association study identifies significant SNP and related genes associated with body size in Yorkshire pigs using latent variable modelling
Authors: Sanjari Banestani Elahe , Esmailizadeh Ali , Momen Mehdi , Ayatollahi Mehrgardi Ahmad , Mokhtari Morteza
Published: September 2023

This study aimed to quantify a latent variable for body size (BS) in pigs by using five linear body measurements including body length (BL), body height (BH), chest width (CW), chest girth (CG) and tube girth (TG), and also to identify the most associated single nucleotide polymorphisms (SNP) and related genes with BS by using the genomic best linear unbiased prediction (GBLUP) based genome-wide association study (GWAS) or GBLUP-GWAS methodology. To perform a GWAS on the BS latent trait, we used a mixed linear model and identified a total of 53 significant SNPs. Additionally, we found that nine genes, including Rho GTPase activating protein 12 (ARHGAP12), transmembrane protein 108 (TMEM108), T-cell lymphoma invasion and metastasis inducing factor 1 (TIAM1), ras homologue gene family member B (RHOB), POU class 4 homeobox 1 (POU4F1), follistatin-related protein 4 (FSTL4), cellular communication network factor 2 (CCN2), beaded filament structural protein 2 (BFSP2) and attractin-like protein 1 (ATRNL1) were associated with the BS trait in pigs. These genes are involved in several biological processes, including the regulation of anatomical structure, morphogenesis, the regulation of cell size and growth. The results suggest that the identified SNP and related genes may play important roles in regulating the growth and development of pigs. The results imply that these genes could be promising candidates for further exploration of the underlying mechanisms of body size variation. Furthermore, the findings have significant practical implications for enhancing the efficiency and profitability of pig farming through genetic selection.
Water use efficiency and yield responses of Cenchrus purpureus genotypes under irrigation
Authors: Ribeiro R. E. P. , Mello A. C. L. , Cunha M. V. , Santos M. V. F. , Costa S. B. M. , Coelho J. J. , Carvalho R. O. , Silva V. J.
Published: September 2023

In tropical regions, water stress is one of the main causes of the reduction in forage productivity, and irrigation strategies can mitigate the problem, especially for highly productive species. The objective of this study was to evaluate the effects of irrigation, genotype and plant size on productive responses and water use efficiency (WUE) of elephant grass (Cenchrus purpureus [Schumach.] Morrone), in the rainy and dry season. The experimental design was randomized in blocks, arranged in split plots, the main plots were established based on the use of irrigation and the subplots were the tall-sized genotypes (IRI 381 and Elephant B) and dwarfs (Taiwan A-146 2.37 and Mott). The genotypes were evaluated for two years and harvested every 60 days. Water use efficiency, total forage accumulation per year and harvest, forage accumulation rate and forage density were evaluated. There was a significant difference between the genotypes in terms of total forage accumulated (P < 0.05). The most productive genotype was IRI 381, which showed the greatest total forage accumulation (42 168 kg of DM/ha in two years) in the irrigated plots. During the rainy seasons, IRI 381 stood out in terms of forage accumulated (24 667 kg of DM/ha). Irrigation favoured increases in forage accumulation around 60%, in both years of evaluation. Irrigation and plant size influenced the productivity and WUE of elephant grass harvested in 60-day intervals. Tall genotypes and Taiwan A-146 2.37 (dwarf size) stood out in most of the productive traits analysed, while Mott was highlighted by its forage density.
The bidirectional association between psychiatric disorders and sheltered homelessness
Authors: Nilsson Sandra Feodor , Wimberley Theresa , Speyer Helene , Hjorthøj Carsten , Fazel Seena , Nordentoft Merete , Laursen Thomas Munk
Published: September 2023

Background

Psychiatric disorders and homelessness are related, but temporal associations are unclear. We aimed to explore the overlap between hospital-based psychiatric disorders and sheltered homelessness.

Methods

This population-based cohort study was conducted using the Danish registers e.g., the Danish Homeless Register and the Danish National Patient Register. The study cohort included all individuals aged 15 years or older, living in Denmark at least one day during 2002–2021 (born 1984–2006). First psychiatric diagnosis was used to define psychiatric disorder and first homeless shelter contact to define homelessness. Adjusted incidence rate ratios (IRRs) and cumulative incidences were estimated.

Results

Among 1 530 325 individuals accounting for 16 787 562 person-years at risk aged 15–38 years, 11 433 (0.8%) had at least one homeless shelter contact. Among 1 406 410 individuals accounting for 14 131 060 person-years at risk, 210 730 had at least one psychiatric disorder. People with any psychiatric disorder had increased risk of sheltered homelessness relative to individuals with no psychiatric disorder [IRR 9.2, 95% confidence interval (CI) 8.8–9.6]. Ten years after first psychiatric disorder, 3.0% (95% CI 2.9–3.1) had at least one homeless shelter contact. Individuals experiencing homelessness had increased risk of any psychiatric disorder compared to individuals with no homeless shelter contact (IRR 7.0, 95% CI 6.7–7.4). Ten years after first homeless shelter contact, 47.1% (45.3–48.0) had received a hospital-based psychiatric diagnosis.

Conclusion

Strong bidirectional associations between psychiatric disorders and homelessness were identified. Health and social care professionals should be aware of and address these high risks of accumulated psychiatric and social problems.
Mixed-methods research in applied linguistics: Charting the progress through the second decade of the twenty-first century
Authors: Riazi A. Mehdi , Farsani Mohammad Amini
Published: September 2023

This review of recent scholarship (RRS) paper is a follow-up of the first, published in this journal in 2014. For this RRS paper, we identified and included 304 mixed-methods research (MMR) papers published in 20 top-tier applied linguistics (AL) journals. We used a six-pronged quality and transparency framework to review and analyze the MMR studies, drawing on six quality frameworks and transparency discussions in the MMR literature. Using the quality and transparency framework, we report on: (1) which sources AL MMR researchers use to frame their studies, (2) how explicitly they explain the purpose and design structure of the MMR studies, (3) how transparently they describe method features (sampling procedures, data sources, and data analysis), and (4) how they integrate quantitative and qualitative data and analyses and construct meta-inferences. The results of the analyses will be reported and will show how MMR has developed and is represented in the published articles in the second decade of the twenty-first century. The discussion of the results will also highlight the areas future AL MMR researchers need to consider to make their studies and reports more rigorous and transparent.
The Low-Back-Merger Shift: Evidence from MENA Americans in the Upper Midwest and southern California
Authors: Sheydaei Iman
Published: September 2023

Middle Eastern or North African (MENA) Americans are an understudied speech community in sociolinguistics. In terms of racial classification and identification, MENA Americans have been legally and historically classified as white but are not socially perceived as white (Beydoun, 2013, 2015). While early immigrants from MENA regions to the US were mostly Christians, ever since 1947, the majority of immigrants from MENA regions to the US have been from Muslim backgrounds (Orfalea, 2006); this demographic change can result in more ethnic visibility for MENA Americans in the US (cf., e.g., Shryock & Lin, 2009, for a discussion of ethnic visibility of MENA Americans in southeastern Michigan). Higher ethnic visibility can in turn lead to certain linguistic performances on the part of MENA Americans. Several studies have looked at the interaction of ethnic identity/visibility and local vowel patterns such as the merging of the low back vowels (the vowels in THOUGHT and LOT1). For example, Hall–Lew (2009) showed that Asian Americans in San Francisco took part in the low back vowel merger and high back vowel fronting, which both index local meanings being part of the California Vowel Shift (Eckert, 2008). Going beyond one particular locality, Wong and Hall–Lew (2014) demonstrated clear influence of local dialect on the speech of Asian Americans in two different localities, with Asian Americans from NYC having distinct low back vowels and those from San Francisco merged low back vowels. Comparing the speech of three different ethnic groups in the multicultural context of Toronto, Hoffman and Walker (2010) explored two features of the Canadian Vowel Shift: the retraction of TRAP and the lowering and retraction of DRESS. Their findings showed that while Chinese Canadians disfavored these two patterns, British/Irish and Italian Canadians favored them. In another study in the context of California English, Cardoso et al. (2016) looked at subclasses of the TRAP vowel in the speech of Chinese Americans and white Americans of San Francisco. They found that the nasal split of TRAP (it being raised when followed by a nasal consonant, and being retracted and lowered when followed by an oral consonant) was more advanced for white speakers than the Chinese group. Cardoso et al. (2016) associated the observed difference to the social meaning of the TRAP nasal split in California indexing white or non-Chicanx social personae.
Regarding Mao's Alleged Speech about the Dalai Lama on 15 November 1956
Authors: Raymond Alex
Published: September 2023

On 15 November 1956, Mao Zedong 毛泽东 delivered a speech at the Second Plenary Session of the Central Committee of the Eighth CCP Congress. The official written version of this speech was published belatedly, in 1977, in the fifth volume of Mao's Selected Works. In this text, Mao was supposed to be talking about the Dalai Lama's forthcoming stay in India, and he had no difficulty in envisaging the Dalai Lama's eventual departure into exile. This passage, obviously, seems problematic as it contradicts the policy of the CCP leadership towards the Dalai Lama at that time. Tsering Shakya (The Dragon in the Land of Snows, Pimlico, 1999), Li Jianglin 李江琳 (1959 Lhasa, New Century Press, 2010), Melvyn Goldstein (A History of Modern Tibet, Volume 3, University of California Press, 2013), and Liu Xiaoyuan 刘晓原 (To the End of Revolution, Columbia University Press, 2020) have successively sought to understand the reason for this. The probable reason seems to be simply that Mao most likely never made these remarks about the Dalai Lama on the date in question, and that this passage was added later in the written version of the speech, to avoid Mao losing face.
Global Climate Policy Beyond the Paris Agreement
Authors: Green Jessica F.
Published: September 2023

Although a subset of political scientists has been studying climate change for decades, the mainstream of the discipline lags behind. Journals such as Global Environmental Politics and even Nature and Science have long published political science research on climate, yet major disciplinary journals tend to marginalize climate and environmental politics more broadly (Green and Hale 2017). This trend has been changing slowly (as evidenced by this symposium), but mainstream political science still has much catching up to do.
Climate Security: How to Write About the Future Without Lapsing into Prophecy
Authors: Busby Joshua W.
Published: September 2023

A robust literature on climate change and security developed in the 2010s. Much of the literature attempts to chart how climate change could contribute directly or indirectly to conflict and instability through impacts on agriculture, migration, and disasters (Busby 2018; Koubi 2019; Theisen 2017).1 The methodological challenge is that climate change is an emergent problem, wherein the security consequences largely have yet to occur. However, the field’s methods and expertise are primarily explanatory of past patterns. For scholars who want to make claims about future security risks, Gledistch (1998, 394) warned of potentially slipping into prophecy. If scholars want to write about climate change and retain academic rigor, what are they to do? This article reviews the challenges for scholars in this space and identifies potential research strategies that might be pursued going forward.
How International Relations Theory on Norm Cascades Can Inform the Politics of Climate Change
Authors: Sikkink Kathryn
Published: September 2023

To confront the climate crisis, we need political change involving a dramatic shift in domestic and transnational norms. Norm models should be recognized as one of the theoretical tools within the panoply of approaches to examine and address climate change. The most promising norm campaigns underway are those that target fossil fuel companies and government policies that support them (e.g., subsidies).
The Politics of Climate Policy Instruments
Authors: Konisky David M.
Published: September 2023

Reducing greenhouse gas emissions that are causing climate change requires the adoption of costly policies with often uncertain efficacy and distributional consequences. Because these emissions occur across sectors of the economy—electricity, transportation, and agriculture—and the built environment, and they require action at all levels of government—global, national, regional, and local—there is no single “silver-bullet” solution.
Precision psychiatry and Research Domain Criteria: Implications for clinical trials and future practice
Authors: Williams Leanne M. , Carpenter William T. , Carretta Carrie , Papanastasiou Evangelos , Vaidyanathan Uma
Published: September 2023

Psychiatric disorders are associated with significant social and economic burdens, many of which are related to issues with current diagnosis and treatments. The coronavirus (COVID-19) pandemic is estimated to have increased the prevalence and burden of major depressive and anxiety disorders, indicating an urgent need to strengthen mental health systems globally. To date, current approaches adopted in drug discovery and development for psychiatric disorders have been relatively unsuccessful. Precision psychiatry aims to tailor healthcare more closely to the needs of individual patients and, when informed by neuroscience, can offer the opportunity to improve the accuracy of disease classification, treatment decisions, and prevention efforts. In this review, we highlight the growing global interest in precision psychiatry and the potential for the National Institute of Health-devised Research Domain Criteria (RDoC) to facilitate the implementation of transdiagnostic and improved treatment approaches. The need for current psychiatric nosology to evolve with recent scientific advancements and increase awareness in emerging investigators/clinicians of the value of this approach is essential. Finally, we examine current challenges and future opportunities of adopting the RDoC-associated translational and transdiagnostic approaches in clinical studies, acknowledging that the strength of RDoC is that they form a dynamic framework of guiding principles that is intended to evolve continuously with scientific developments into the future. A collaborative approach that recruits expertise from multiple disciplines, while also considering the patient perspective, is needed to pave the way for precision psychiatry that can improve the prognosis and quality of life of psychiatric patients.
Cross-linguistic influence in the bilingual lexicon: Evidence for ubiquitous facilitation and context-dependent interference effects on lexical processing
Authors: Bailey Lyam M. , Lockary Kate , Higby Eve
Published: September 2023

For bilinguals, lexical access in one language may affect, or be affected by, activation of words in another language. Research to date suggests seemingly contradictory effects of such cross-linguistic influence (CLI): in some cases CLI facilitates lexical access while in others it is a hindrance. Here we provide a comprehensive review of CLI effects drawn from multiple disciplines and paradigms. We describe the contexts within which CLI gives rise to facilitation and interference and suggest that these two general effects arise from separate mechanisms that are not mutually exclusive. Moreover, we argue that facilitation is ubiquitous, occurring in virtually all instances of CLI, while interference is not always present and depends on levels of cross-language lexical competition. We discuss three critical factors – language context, direction, and modality of CLI – which appear to modulate facilitation and interference. Overall, we hope to provide a general framework for investigating CLI in future research.
Brains and Minds
Authors: Churchland Patricia
Published: September 2023

How can and does science – and especially neuroscience – inform the philosophical puzzle of mind and body?
Love and Grief (Loving better through Grief)
Authors: Whiston Amna
Published: September 2023

When, in the wake of the September 11 terrorist attacks on the World Trade Center in New York more than two decades ago, the late Queen Elizabeth II expressed her sentiments with the words: ‘Grief is the price we pay for love’, she was making a reference to British psychiatrist Dr Colin Murray Parkes's book Bereavement: Studies of Grief in Adult Life. In the book, Dr Parkes states an obvious, albeit often ignored, fact that the pain of grief is just as much part of life as the joy of love. Following the death of the Queen in September 2022, Joe Biden, the current president of the US, used the same quote as an opportunity to express his own personal sadness about her passing. It was also an opportunity to participate in public grief about the loss of a popular leader, and of innocent lives. It is not uncommon for leaders, religious ones including, to speak of love, especially during such poignant moments. But it is somewhat less common for public figures to bring to our attention the close connection between grief and love. Even when they do, grief is commonly seen in a negative light. Philosophers provide another example of what is, I shall argue, a mischaracterization of grief.
Analysis of genetic divergence, principal component, correlation and path coefficient for quantitative traits of Gerbera (Gerbera jamesonii) in the north eastern region, India
Authors: Rymbai Heiplanmi , Verma V.K. , Mawleiñ J. , Hazarika S.
Published: September 2023

Gerbera is an important commercial flower crop in the world. Augmenting the genetic diversity is desirable for further improvement in Gerbera breeding programme. Thirty-seven (37) Gerbera accessions were evaluated and analysed for genetic variability, heritability, correlation and path coefficient analysis using yield and quality traits. Results showed that phenotypic coefficients were higher than genotypic coefficients of variation for all the characters. All the traits, except stalk and flower diameter, had high heritability (>60%) and genetic advance (>20%). Based on cluster analysis, the 37 accessions were grouped into seven clusters. Cluster I consists of the maximum number of genotypes (22), while clusters IV–VII are monogenotypic with unique traits. Cluster analysis (D2) showed wider genetic diversity within and between the clusters. The first four principal components (Eigenvalue >1) contributed 72.3% of the total variation. The number of leaves, number of flowers and flower stalk length contributed the most to genetic divergence. Flower yield showed a significant positive genotypic correlation with the number of leaves and suckers. The path analysis (genotypic) revealed that number of suckers, flower stalk diameter and flower stalk length contribute major positive direct effects on number of flowers. Therefore, the wide genetic variability existing in the germplasm may facilitate improvement in gerbera crops. Superior lines (RCGH-12, -22, -114, -117) with higher yield (>23 flowers/plant) and vase life (>5 days) could be promoted for commercial production under open field conditions. While RCGH 28 has a dwarf flower stalk that can be promoted for pots and decoration purposes.
Shock me like a Hurricane: how Hurricane Katrina changed Louisiana's formal and informal institutions
Authors: Rayamajhee Veeshan , March Raymond J. , Clark Corbin C. T.
Published: September 2023

Institutions matter for postdisaster recovery. Conversely, natural disasters can also alter a society's institutions. Using the synthetic control method, this study examines the effects that Hurricane Katrina (2005) had on the formal and informal institutions in Louisiana. As measures of formal institutions, we employ two economic freedom scores corresponding to government employment (GE) (as a share of total employment at the state-level) and property tax (PT). These measures serve as proxies for the level of governmental interference into the economy and the protection of private property rights respectively. To assess the impact on informal institutions, we use state-level social capital data. We find that Hurricane Katrina had lasting impacts on Louisiana's formal institutions. In the post-Katrina period, we find that actual Louisiana had persistently higher economic freedom scores for both GE and PT than the synthetic Louisiana that did not experience the hurricane. These findings imply that the hurricane led to a reduction in both PTs and GE, which indicates a decrease in the relative size of the public sector as a share of the state's economy. On the other hand, we find no impact on our chosen measure of informal institution.
Mars Has Far Fewer Minerals Than Earth Does
Authors: Fritts Rachel
Published: September 2023

The development of plate tectonics and life on Earth provided avenues for mineral evolution that did not occur on Mars, resulting in relatively limited mineral diversity on the Red Planet.
Soil Moisture Dominates the Forest Productivity Decline During the 2022 China Compound Drought‐Heatwave Event
Authors: Zhao Dayang , Zhang Zhaoying , Zhang Yongguang
Published: September 2023

Compound drought‐heatwave (CDHW) events threaten ecosystem productivity and are often characterized by low soil moisture (SM) and high vapor pressure deficit (VPD). However, the relative roles of SM and VPD in constraining forest productivity during CDHWs remain controversial. In the summer of 2022, China experienced a record‐breaking CDHW event (DH2022). Here, we applied satellite remote‐sensing data and meteorological data, and machine‐learning techniques to quantify the individual contributions of SM and VPD to forest productivity variations and investigate their interactions during the development of DH2022. The results reveal that SM, rather than VPD, dominates the forest productivity decline during DH2022. We identified a possible critical tipping point of SM below which forest productivity would quickly decline with the decreasing SM. Furthermore, we illuminated the evolution of SM, VPD, evapotranspiration, forest productivity, and their interactions throughout DH2022. Our findings broaden the understanding of forest response to extreme CDHWs at the ecosystem scale.
Tropical Wave Observations From the Reel‐Down Atmospheric Temperature Sensor (RATS) in the Lowermost Stratosphere During Strateole‐2
Authors: Bramberger Martina , Goetz Doug , Alexander M. Joan , Kalnajs Lars , Hertzog Albert , Podglajen Aurelien
Published: September 2023

Tropical waves play an important role in driving the quasi‐biennial oscillation of zonal winds in the tropical stratosphere. In our study we analyze these waves based on temperature observations from the 2021–2022 Strateole‐2 campaign when the Reel‐down Atmospheric Temperature Sensor (RATS) was successfully deployed for the first time. RATS provides long‐duration, continuous and simultaneous high‐resolution temperature observations at two altitudes (balloon float level and 200 m below) allowing for an analysis of vertical wavelengths. This separation distance was chosen to focus on waves near the resolution limit of reanalyses. Here, we found tropical waves with periods between about 6 hr and 2 days, with vertical wavelengths between 1.5 and 5 km, respectively. Comparing our results to Fifth generation European Centre for Medium‐Range Weather Forecasts (ERA5) reanalyses we found good agreement for waves with a period longer than 1 day. However, the ERA5 amplitudes of higher‐frequency waves are under‐estimated, and the temporal evolution of most wave packets differs from the observations.
Arctic Spring Systems Driven by Permafrost Aggradation
Authors: Hornum Mikkel Toft , Bense Victor , van der Ploeg Martine , Kroon Aart , Sjöberg Ylva
Published: September 2023

Groundwater springs in permafrost regions provide pathways for solutes and dissolved gases to escape from sub‐permafrost groundwater systems, which otherwise are completely isolated from the surface environment and atmosphere. Yet, fundamental questions as to the mechanisms driving groundwater flow to the surface remain unsolved. In this study, basal permafrost aggradation is explored as a mechanism for generating groundwater flow and driving groundwater spring systems. We employ process‐based numerical modeling to test the hypothesis of permafrost‐aggradation‐driven spring systems in a range of environmental settings. The model results show that permafrost aggradation can generate spring flow on a multi‐millennial timescale and with discharge rates up to a couple of liters per second. Permafrost aggradation deserves attention as a groundwater flow driving mechanism in areas of recent glacio‐isostatic uplift and glacial retreat.
Seasonally Evolving Trends Explain the North‐South Dipole Pattern Observed in Tibetan Plateau Precipitation
Authors: Ma Jieru , Ren Hong‐Li , Cai Ming , Huang Jianping
Published: September 2023

The Tibetan Plateau (TP) precipitation is experiencing the north‐south dipole tendency pattern since 1979. In this study, we identify four primary seasonally evolving patterns (SEPs) that explain approximately 50% of the total variance in precipitation variability over the TP. These SEPs contribute 60%–90% of the spatial mean amplitude of precipitation trends across seasons. In particular, the second SEP that features a north‐south dipole pattern dominates the annual mean trend of the precipitation over the TP. The interdecadal variability of the seasonally evolving north‐south dipole pattern is linked to the interdecadal variations of summer Silk Road Pattern and Indian monsoon. These findings suggest that the climate variability expressed through SEPs could potentially serve as a significant source for the interdecadal rainfall prediction.
Systematic Detection of Short‐Term Slow Slip Events in Southcentral Alaska
Authors: Okada Yutaro , Nishimura Takuya
Published: September 2023

Slow slip events (SSEs) are important for the slip budget along a megathrust fault. Although the recurrence of weeks‐long short‐term SSEs (S‐SSEs) in southcentral Alaska has been suggested, a large amount of noise prevented us from detecting discrete events. We applied a systematic detection method to Global Navigation Satellite System data and detected 31 S‐SSEs during the 14‐year analysis period. The events mainly occurred at a depth from 35 to 45 km at a down‐dip extension of the 1964 Alaska earthquake, and the active clusters correlated with the region of the subducting Yakutat microplate. A large cumulative slip of S‐SSEs indicated a significant contribution to stress transfer along the plate interface, and its source area spatially coincided with that of the long‐term SSEs and the afterslip of the 1964 earthquake. Large and recurrent S‐SSEs are key phenomena for understanding interplate slip kinematics in this region.
Observations of Tilted Electron Vortex Flux Rope in the Magnetic Reconnection Tailward Outflow Region
Authors: Jiang K. , Huang S. Y. , Yuan Z. G. , Xiong Q. Y. , Wei Y. Y.
Published: September 2023

With high‐resolution data from Magnetospheric Multiscale (MMS) mission, an ion‐scale flux rope (FR) with a heavily tilted axis is observed in the tailward outflow of a magnetic reconnection in the terrestrial magnetotail. Combined with the field‐aligned electron distribution and positions of MMS when the X‐line and FR are observed, the tilted axis is inferred to be caused by the extension of the X‐line in the dawn‐dusk direction. J · E′ is negative and electrons are losing energy in the FR. An ion‐scale electron vortex embedded in the plane perpendicular to the axis is observed inside FR. The induced magnetic field generated by the electron vortex has the same direction as the axial component, which can contribute to the axial component and increase the magnetic flux of the FR. Such electron vortex FRs may be an essential carrier of magnetic flux from near‐Earth X‐line to distant X‐line or interplanetary space.
MANGO: An Optical Network to Study the Dynamics of the Earth's Upper Atmosphere
Authors: Bhatt A. N. , Harding B. J. , Makela J. J. , Navarro L. , Lamarche L. J. , Valentic T. , Kendall E. A. , Venkatraman P.
Published: September 2023

The Mid‐latitude All‐sky‐imaging Network for Geophysical Observations (MANGO) employs a combination of two powerful optical techniques used to observe the dynamics of Earth's upper atmosphere: wide‐field imaging and high‐resolution spectral interferometry. Both techniques observe the naturally occurring airglow emissions produced in the upper atmosphere at 630.0‐ and 557.7‐nm wavelengths. Instruments are deployed to sites across the continental United States, providing the capability to make measurements spanning mid to sub‐auroral latitudes. The current instrument suite in MANGO has six all‐sky imagers (ASIs) observing the 630.0‐nm emission (integrated between ∼200 and 400 km altitude), six ASIs observing the 557.7‐nm emission (integrated between ∼90 and 100 km altitude), and four Fabry‐Perot interferometers measuring neutral winds and temperature at these wavelengths. The deployment of additional imagers is planned. The network makes unprecedented observations of the nighttime thermosphere‐ionosphere dynamics with the expanded field‐of‐view provided by the distributed network of instruments. This paper describes the network, the instruments, the data products, and first results from this effort.
Alongshore Winds Force Warm Atlantic Water Toward Helheim Glacier in Southeast Greenland
Authors: Snow T. , Zhang W. , Schreiber E. , Siegfried M. , Abdalati W. , Scambos T.
Published: September 2023

Enhanced transport of warm subsurface Atlantic Water (AW) into Greenland fjords has driven glacier mass loss, but the mechanisms transporting AW to the fjords remain poorly characterized. Here, we provide the first direct satellite‐based observations of rapid (∼0.2 m/s) AW intrusion toward Sermilik Fjord abutting Helheim Glacier, one of Greenland's largest glaciers. The intrusions arise when coastal upwelling—through interactions with Sermilik's bathymetric trough on the continental shelf—triggers enhanced AW upwelling and inflow that can travel tens of kilometers along the trough within hours. A weakening or reversal of northeasterly alongshore winds stimulates the intrusions and is often associated with the passing of cyclones and subsequent sea surface lowering. Mooring data show that these intrusions produce subsurface ocean warming both at Sermilik Fjord mouth and within the fjord and that the warming signal in the fjord does not diminish during subsequent coastal downwelling events. Satellite imagery captures near‐synchronous AW intrusions at multiple troughs rimming southeast Greenland suggesting that these wind‐driven processes may play a substantial role in ocean heat transport toward the Greenland Ice Sheet.
Regional Variability in the Environmental Controls of Precipitation Regimes in the Tropics
Authors: Hagos Samson , Feng Zhe , Tai Sheng‐Lun , Chen Jingyi
Published: September 2023

The environmental factors that control precipitation regimes in Boreal winter rainfall in the tropics and their regional variabilities are examined using a simple statistical analysis and a machine learning (ML) model. Radar‐derived precipitation from field campaigns at Darwin Australia, Manaus Brazil, and the Equatorial Indian Ocean, along with the corresponding large‐scale environmental variables from ERA5 reanalysis, are used. The dependence of marginal distributions of frequencies of these regimes on five environmental variables are calculated. The variables are hourly column integrated precipitable water (PW), convective available potential energy, convective inhibition (CIN), and lower and upper tropospheric wind shear. The simple ML model that predicts the probability of transition from suppressed to an active regime as a function of the environmental variables is designed and optimized for a potential application as a trigger function for convection parameterizations. To the first order the analysis shows an abrupt increase in the probability of an active regime near PW > 60 mm and CIN of <100 J kg−1. The key differences in the frequencies of active regimes among the regions are found to be related to the fact that over Darwin there is strong variability in PW while CIN is generally low. Over Amazon, on the other hand, both PW and CIN are quite variable. Over the Dynamics of the Madden‐Julian Oscillation domain the comparatively frequent low PW is compensated for by consistently low CIN resulting in a moderate frequency of an active regime.
Efficacy and safety of front-line treatment regimens for Waldenstrom macroglobulinaemia: a systematic review and meta-analysis
Authors: Chan Wee-Lee , Chong Vanessa Cui Lian , Wee Ian Jun Yan , Poon Li Mei , Chan Esther Hian Lee , Lee Joanne , Chee Yen-Lin , Jeyasekharan Anand D. , Chng Wee-Joo , Samuel Miny , de Mel Sanjay
Published: September 2023

Rituximab-based chemo-immunotherapy is currently the standard first-line treatment for Waldenstrom macroglobulinaemia (WM), while ibrutinib has emerged as an alternative. In the absence of randomised trials (RCTs) comparing these regimens, the optimal first-line treatment for WM remains uncertain. In this systematic review and meta-analysis, we sought to assess the efficacy and safety of first-line treatment regimens for WM. We searched key databases from January 2007 to March 2023, including phase II and III trials, including treatment-naïve WM patients treated with rituximab-based regimens or ibrutinib. Response rates, progression-free survival (PFS), overall survival (OS), and toxicities were evaluated. Four phase III and seven phase II trials were included among 736 unique records. Pooled response rates from all comparative and non-comparative trials were 46%, 33% and 26% for bendamustine rituximab (BR), bortezomib-dexamethasone, cyclophosphamide, rituximab (BDRC) and ibrutinib rituximab (IR), respectively. Two-year pooled PFS was 89%, 81% and 82% with BR, BDRC and IR, respectively. Neuropathy was more frequent with bortezomib, while haematologic and cardiac toxicities were more common with chemo-immunotherapy and ibrutinib-based regimens respectively. Our findings suggest that BR yields higher response rates than bortezomib or ibrutinib-based combinations. RCTs comparing BR against emerging therapies, including novel Bruton Tyrosine Kinase Inhibitors, are warranted.
TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs
Authors: Vashisht Monika , Ge Huaibin , John Jessy , McKelvey Harlie A. , Chen Jingxin , Chen Zhangguo , Wang Jing H.
Published: September 2023

Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown whether deletion of such factors affects B cells’ ability to tolerate DNA damage, which can be induced by chemotherapeutics and cause apoptosis. Genetic alterations of TRAF2 or TRAF3 are observed in subsets of human B-cell lymphomas and B cell-specific deletion of TRAF3 led to lymphoma development in aged mice. However, it remains unknown whether double deficiency of TRAF2 and TRAF3 accelerates B-cell lymphomagenesis. Here, we showed that B cell-specific TRAF2/3 double deficient (B-TRAF2/3-DKO) B cells were remarkably more resistant to DNA damage-induced apoptosis via upregulating cIAP2 and XIAP, which in turn attenuates caspase-3 activation. Mechanistically, resistance to DNA damage-induced apoptosis required NF-κB2, which effects by upregulating XIAP and cIAP2 transcription. B-TRAF2/3-DKO mice exhibited a shorter lifespan and succumbed to splenomegaly and lymphadenopathy. Unexpectedly, the incidence of B-cell lymphoma development in B-TRAF2/3-DKO mice was relatively rare (∼10%). Sequencing B cell receptor repertoire of diseased B cells revealed that TRAF2/3 deficiency caused abnormal oligoclonal or clonal expansion of B cells. While a fraction of mutant B cells (25–43%) from aged diseased mice harbored recurrent chromosomal translocations, primary B cells isolated from young B-TRAF2/3-DKO mice had no detectable chromosomal alterations, suggesting that TRAF2/3 deficiency per se does not cause evident genomic instability in B cells. Chemo-resistant TRAF3-deficient B-cell lymphomas were sensitized to chemotherapeutic drugs by blocking IAP activity using IAP antagonist. We conclude that double deficiency of TRAF2 and TRAF3 does not accelerate B-cell lymphomagenesis. Our studies provide insight into mechanisms regulating DNA damage-induced apoptosis and may help develop effective therapies targeting mutant B-cell lymphomas using IAP antagonist.
PGC-1α inhibits M2 macrophage polarization and alleviates liver fibrosis following hepatic ischemia reperfusion injury
Authors: Zhang Yanting , Zhang Linzhong , Zhao Yanmian , He Jing , Zhang Yanghao , Zhang Xiuying
Published: September 2023

Oxidative stress can induce inflammation, promoting macrophage polarization and liver fibrosis following hepatic ischemia-reperfusion (I/R). Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has anti-oxidant and anti-inflammatory activity. However, how PGC-1α regulates macrophage polarization following hepatic I/R remains largely unknown. Male C57BL/6 wild-type mice were pre-treated with vehicle or trichostatin A (TSA) for 2 days and subjected to surgical induction of I/R. Liver injury and fibrosis in individual mice were examined longitudinally and the expression levels of IL-6, STAT3, M2-type macrophage markers, Collagen I and α-SMA in the liver of mice were analyzed by immunohistochemistry, RT-qPCR and Western blot. The potential interaction of PGC-1α with phosphorylated NF-kBp65 was determined by immunoprecipitation. The impacts of PGC-1α deficiency in hepatocytes on their IL-6 production and macrophage polarization were tested in a Transwell co-culture system. Moreover, the M2-type macrophage polarization and liver fibrosis were examined in hepatocyte-specific PGC-1α knockout mice and AAV8-mediated PGC-1α over-expressing mice following liver I/R. The down-regulated PGC-1α expression by I/R was negatively correlated with IL-6 levels in the liver of I/R mice and PGC-1α deficiency enhanced IL-6 expression, STAT3 activation and M2-type macrophage polarization in the I/R mice, which were abrogated by TSA treatment. In addition, PGC-1α directly interacted with phosphorylated NF-kBp65 in I/R livers. Hepatocyte-specific PGC-1α deficiency increased IL-6 production and promoted macrophage polarization toward M2 type when co-culture. More importantly, administration with AAV8-PGC-1α rescued the I/R-induced liver fibrosis by inhibiting the IL-6/JAK2/STAT3 signaling and M2-type macrophage polarization in the liver. These results suggest that PGC-1α may alleviate the I/R-induced liver fibrosis by attenuating the IL-6/JAK2/STAT3 signaling to limit M2-type macrophage polarization. PGC-1α may be a therapeutic target for the treatment of liver fibrosis.
Demonstration of an AI-driven workflow for autonomous high-resolution scanning microscopy
Authors: Kandel Saugat , Zhou Tao , Babu Anakha V. , Di Zichao , Li Xinxin , Ma Xuedan , Holt Martin , Miceli Antonino , Phatak Charudatta , Cherukara Mathew J.
Published: September 2023

Modern scanning microscopes can image materials with up to sub-atomic spatial and sub-picosecond time resolutions, but these capabilities come with large volumes of data, which can be difficult to store and analyze. We report the Fast Autonomous Scanning Toolkit (FAST) that addresses this challenge by combining a neural network, route optimization, and efficient hardware controls to enable a self-driving experiment that actively identifies and measures a sparse but representative data subset in lieu of the full dataset. FAST requires no prior information about the sample, is computationally efficient, and uses generic hardware controls with minimal experiment-specific wrapping. We test FAST in simulations and a dark-field X-ray microscopy experiment of a WSe2 film. Our studies show that a FAST scan of <25% is sufficient to accurately image and analyze the sample. FAST is easy to adapt for any scanning microscope; its broad adoption will empower general multi-level studies of materials evolution with respect to time, temperature, or other parameters.
Multifaceted information-seeking motives in children
Authors: Molinaro Gaia , Cogliati Dezza Irene , Bühler Sarah Katharina , Moutsiana Christina , Sharot Tali
Published: September 2023

From an early age, children need to gather information to learn about their environment. Deciding which knowledge to pursue can be difficult because information can serve several, sometimes competing, purposes. Here, we examine the developmental trajectories of such diverse information-seeking motives. Over five experiments involving 521 children (aged 4–12), we find that school-age children integrate three key factors into their information-seeking choices: whether information reduces uncertainty, is useful in directing action, and is likely to be positive. Choices that likely reveal positive information and are useful for action emerge as early as age 4, followed by choices that reduce uncertainty (at ~age 5). Our results suggest that motives related to usefulness and uncertainty reduction become stronger with age, while the tendency to seek positive news does not show a statistically significant change throughout development. This study reveals how the relative importance of diverging, sometimes conflicting, information-seeking motives emerges throughout development.
Nanoscale ductile fracture and associated atomistic mechanisms in a body-centered cubic refractory metal
Authors: Lu Yan , Chen Yongchao , Zeng Yongpan , Zhang Yin , Kong Deli , Li Xueqiao , Zhu Ting , Li Xiaoyan , Mao Shengcheng , Zhang Ze , Wang Lihua , Han Xiaodong
Published: September 2023

Understanding the competing modes of brittle versus ductile fracture is critical for preventing the failure of body-centered cubic (BCC) refractory metals. Despite decades of intensive investigations, the nanoscale fracture processes and associated atomistic mechanisms in BCC metals remain elusive due to insufficient atomic-scale experimental evidence. Here, we perform in situ atomic-resolution observations of nanoscale fracture in single crystals of BCC Mo. The crack growth process involves the nucleation, motion, and interaction of dislocations on multiple 1/2 < 111 > {110} slip systems at the crack tip. These dislocation activities give rise to an alternating sequence of crack-tip plastic shearing, resulting in crack blunting, and local separation normal to the crack plane, leading to crack extension and sharpening. Atomistic simulations reveal the effects of temperature and strain rate on these alternating processes of crack growth, providing insights into the dislocation-mediated mechanisms of the ductile to brittle transition in BCC refractory metals.
Benefit-cost analysis of coordinated strategies for control of rabies in Africa
Authors: Bucher A. , Dimov A. , Fink G. , Chitnis N. , Bonfoh B. , Zinsstag J.
Published: September 2023

Previous research suggests that dog mass vaccination campaigns can eliminate rabies locally, resulting in large human and animal life gains. Despite these demonstrated benefits, dog vaccination programs remain scarce on the African continent. We conducted a benefit-cost analysis to demonstrate that engaging into vaccination campaigns is the dominant strategy for most countries even in the absence of coordinated action between them. And quantify how coordinated policy measures across countries in Africa could impact rabies incidence and associated costs. We show that coordinated dog mass vaccination between countries and PEP would lead to the elimination of dog rabies in Africa with total welfare gains of USD 9.5 billion (95% CI: 8.1 – 11.4 billion) between 2024 and 2054 (30 years). Coordinated disease control between African countries can lead to more socially and ecologically equitable outcomes by reducing the number of lost human lives to almost zero and possibly eliminating rabies.
Plant immunity suppression by an exo-β-1,3-glucanase and an elongation factor 1α of the rice blast fungus
Authors: Liu Hang , Lu Xunli , Li Mengfei , Lun Zhiqin , Yan Xia , Yin Changfa , Yuan Guixin , Wang Xingbin , Liu Ning , Liu Di , Wu Mian , Luo Ziluolong , Zhang Yan , Bhadauria Vijai , Yang Jun , Talbot Nicholas J. , Peng You-Liang
Published: September 2023

Fungal cell walls undergo continual remodeling that generates β-1,3-glucan fragments as products of endo-glycosyl hydrolases (GHs), which can be recognized as pathogen-associated molecular patterns (PAMPs) and trigger plant immune responses. How fungal pathogens suppress those responses is often poorly understood. Here, we study mechanisms underlying the suppression of β-1,3-glucan-triggered plant immunity by the blast fungus Magnaporthe oryzae. We show that an exo-β-1,3-glucanase of the GH17 family, named Ebg1, is important for fungal cell wall integrity and virulence of M. oryzae. Ebg1 can hydrolyze β-1,3-glucan and laminarin into glucose, thus suppressing β-1,3-glucan-triggered plant immunity. However, in addition, Ebg1 seems to act as a PAMP, independent of its hydrolase activity. This Ebg1-induced immunity appears to be dampened by the secretion of an elongation factor 1 alpha protein (EF1α), which interacts and co-localizes with Ebg1 in the apoplast. Future work is needed to understand the mechanisms behind Ebg1-induced immunity and its suppression by EF1α.