bluuebunny/crossref_metadata_2025 huggingface dataset:
The Adaptive Complexity of Cancer
Authors: Derbal Youcef
Published: December 2018

Cancer treatment options are expanding to the benefit of significant segments of patients. However, their therapeutic power is not equally realized for all cancer patients due to drug toxicity and disease resistance. Overcoming these therapeutic challenges would require a better understanding of the adaptive survival mechanisms of cancer. In this respect, an integrated view of the disease as a complex adaptive system is proposed as a framework to explain the dynamic coupling between the various drivers underlying tumor growth and cancer resistance to therapy. In light of this system view of cancer, the immune system is in principal the most appropriate and naturally available therapeutic instrument that can thwart the adaptive survival mechanisms of cancer. In this respect, new cancer therapies should aim at restoring immunosurveillance by priming the induction of an effective immune response through a judicious targeting of immunosuppression, inflammation, and the tumor nutritional lifeline extended by the tumor microenvironment.
Solitary CNS Metastasis on Initial Presentation of High Grade Serous Carcinoma of the Fallopian Tube
Authors: Harl Felicity , Niemi Cassandra , Mankowski Gettle Lori , Weisman Paul , Rose Stephen
Published: December 2018

A 68-year-old woman presented with a three-week history of confusion and anomic aphasia. Imaging of her head demonstrated a single large left frontal mass. Pathology revealed metastatic adenocarcinoma of Müllerian origin. Subsequent surgery revealed a small primary site in a fallopian tube, high left para-aortic lymphadenopathy, and no disseminated intraperitoneal disease. This case was remarkable in that CNS metastasis was her presenting symptom and was restricted to a solitary brain lesion, and other disease sites were limited to retroperitoneal lymphadenopathy and a small fallopian tube primary.
Determination of Free Amino Acids in Three Species of Duckweed (Lemnaceae)
Authors: Zhang Xiaolong , Chen Hongyan , Wu Dawei , Gu Wei , Sun Xiao , Chen Jian , Wu Qinan
Published: December 2018

In this study, a fast, simple, precise, and sensitive hydrophilic interaction liquid chromatography (HILIC) method was established for simultaneous determination of free amino acids in three different varieties of duckweed including Spirodela polyrhiza (L.) Schleid., Landoltia punctata (G. Mey.) Les & D. J. Crawford, and Lemna aequinoctialis Welwitsch by ultrahigh performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). Method validation was processed in terms of linearity, precision, stability, repeatability, and accuracy as well as limits of detection and quantification. The developed method was applied for quantification of 59 batches of samples. Then chemometric analysis was used to evaluate different duckweeds by principle component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA). The results demonstrated that there was no significant difference in FAAs’ profile among three varieties of duckweed.
UWB/PDR Tightly Coupled Navigation with Robust Extended Kalman Filter for NLOS Environments
Authors: Li Xin , Wang Yan , Khoshelham Kourosh
Published: December 2018

The fusion of ultra-wideband (UWB) and inertial measurement unit (IMU) is an effective solution to overcome the challenges of UWB in nonline-of-sight (NLOS) conditions and error accumulation of inertial positioning in indoor environments. However, existing systems are based on foot-mounted or body-worn IMUs, which limit the application of the system to specific practical scenarios. In this paper, we propose the fusion of UWB and pedestrian dead reckoning (PDR) using smartphone IMU, which has the potential to provide a universal solution to indoor positioning. The PDR algorithm is based on low-pass filtering of acceleration data and time thresholding to estimate the step length. According to different movement patterns of pedestrians, such as walking and running, several step models are comparatively analyzed to determine the appropriate model and related parameters of the step length. For the PDR direction calculation, the Madgwick algorithm is adopted to improve the calculation accuracy of the heading algorithm. The proposed UWB/PDR fusion algorithm is based on the extended Kalman filter (EKF), in which the Mahalanobis distance from the observation to the prior distribution is used to suppress the influence of abnormal UWB data on the positioning results. Experimental results show that the algorithm is robust to the intermittent noise, continuous noise, signal interruption, and other abnormalities of the UWB data.
Delivery of Retained Second Twin in Case of Omphalopagus Conjoined Twins: Abdominovaginal Approach
Authors: Sisay Woldeyes Wondimagegnehu
Published: December 2018

Conjoined twin is a rare complication of monozygotic twins resulting from incomplete splitting of an embryo into two separate twins or early secondary fusion of two originally separated embryos. When diagnosed at early gestation, one can get adequate time to counsel the family on whether to continue with the pregnancy and proper intervention can be planned. On the other hand, undiagnosed cases may be first recognized in labor after they have caused labor-related complications. In the present case report, an undiagnosed case of a conjoined twin has presented in labor followed by delivery of one baby with the retention of the second baby. This presented a unique challenge to the managing team and required hysterotomy to effect delivery of the unborn baby. We report this case to highlight the importance of early diagnosis of a conjoined twin. On another hand where this does not happen and a conjoined twin is suspected for the first time after it has caused labor-related complications, the management should be individualized based on the clinical circumstance.
Connectivity Analysis in Vehicular Networks with Slight Traffic Interference
Authors: Pan Bin , Wu Hao
Published: December 2018

This paper analyzes the network connectivity in vehicular networks with slight traffic interference, i.e., small‐scale traffic accident. In this paper, we develop an analytical model for highway scenarios or sparse urban scenarios, where the slight traffic interference can make the vehicles slow down rather than block the traffic flow. When a traffic accident occurs, it is necessary to inform the nearby vehicles to slow down in order to reduce congestion at the accident location. Once they pass by, they can return to the normal value. Consequently, we can divide an entire road into two or three subsections, which helps us to analyze the connectivity performance. In addition, we analyze the impact of several key parameters on connectivity probability, including vehicle arrival rate, vehicle communication range, length of road, vehicle normal speed, and safe speed. All analytical results are verified through Monte Carlo simulation experiments. The simulation results are very close to analytical results, which means that the analytical results are accurate and the analytical model we propose is effective.
Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor
Authors: Saito Shiori , Kikuchi Jiro , Koyama Daisuke , Sato Shin , Koyama Hiroo , Osada Naoki , Kuroda Yoshiaki , Akahane Koshi , Inukai Takeshi , Umehara Takashi , Furukawa Yusuke
Published: December 2018

Purpose:

Lysine-specific demethylase 1 (LSD1) regulates several biological processes via the bifunctional modulation of enhancer functions. Recently, we reported that LSD1 overexpression is a founder abnormality of T-cell leukemogenesis and is maintained in fully transformed T-cell acute lymphoblastic leukemia (T-ALL) cells. On the basis of this finding, we attempted to develop novel LSD1 inhibitors effective for T-ALL with central nervous system (CNS) involvement.

Experimental Design:

We chemically modified the prototype LSD inhibitor tranylcypromine (TCP) and screened for cytotoxicity against TCP-resistant T-ALL cell lines. In vivo efficacy of novel LSD1 inhibitors was examined in immunodeficient mice transplanted with luciferase-expressing T-ALL cell lines, which faithfully reproduce human T-ALL with CNS involvement.

Results:

We found robust cytotoxicity against T-ALL cells, but not normal bone marrow progenitors, for two N-alkylated TCP derivatives, S2116 and S2157. The two compounds induced apoptosis in TCP-resistant T-ALL cells in vitro and in vivo by repressing transcription of the NOTCH3 and TAL1 genes through increased H3K9 methylation and reciprocal H3K27 deacetylation at superenhancer regions. Both S2116 and S2157 significantly retarded the growth of T-ALL cells in xenotransplanted mice and prolonged the survival of recipients as monotherapy and in combination with dexamethasone. Notably, S2157 could almost completely eradicate CNS leukemia because of its ability to efficiently pass through the blood–brain barrier.

Conclusions:

These findings provide a molecular basis and rationale for the inclusion of a brain-permeable LSD1 inhibitor, S2157, in treatment strategies for T-ALL with CNS involvement.
Imaging of Myocardial Fibrosis and Its Functional Correlates in Aortic Stenosis: A Review and Clinical Potential
Authors: Katbeh Asim , Ondrus Tomas , Barbato Emanuele , Galderisi Maurizio , Trimarco Bruno , Van Camp Guy , Vanderheyden Marc , Penicka Martin
Published: December 2018

Patients with severe aortic stenosis (AS) show progressive fibrotic changes in the myocardium, which may impair cardiac function and patient outcomes even after successful aortic valve replacement. Detection of patients who need an early operation remains a diagnostic challenge as myocardial functional changes may be subtle. In recent years, speckle tracking echocardiography (STE) and cardiac magnetic resonance mapping have been shown to provide complementary information for the assessment of left ventricular mechanics and identification of subtle damage by focal or diffuse myocardial fibrosis, respectively. Little is known, however, about how focal and diffuse myocardial fibrosis occurring in severe AS are related to measurable functional changes by echocardiography and to which extent both parameters have prognostic and diagnostic value. The aims of this review are to discuss the occurrence of focal and diffuse myocardial fibrosis in patients with severe AS and to explore their relation with myocardial function, determined by STE, as well as the prognostic and diagnostic potential of both parameters.
Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma
Authors: Wang Dongyang , Zhang Jianjun , Li Zengjun , Han Jianjun , Gao Yongsheng , Chen Ming , Li Yanqing
Published: December 2018

Fibroblast growth factor 19 (FGF19) promotes tumor growth in various types of cancer, but its function has not been investigated in the context of colorectal adenoma. Here, we report that FGF19 expression was greater in colorectal adenoma than in normal tissues, as measured by an enzyme-linked immunosorbent assay, quantitative reverse-transcription PCR and immunohistochemistry. FGF19 expression was also elevated in a subset of human colon cancer cell lines. Moreover, FGF receptor 4 (FGFR4), the cognate receptor for FGF19, was upregulated in colorectal adenoma tissues. Lipid levels and body mass index values strongly correlated with FGF19 and FGFR4 levels in patients with colon adenomas. These observations indicate that the FGF19/FGFR4 pathway may be involved in the development of neoplasia, and that FGF19 may be a valuable diagnostic marker for the identification of patients with colorectal adenomas.
Sickle Cell Nephropathy in the Pediatric Population
Authors: Olaniran Kabir O. , Eneanya Nwamaka D. , Nigwekar Sagar U. , Vela-Parada Xavier F. , Achebe Maureen M. , Sharma Amita , Thadhani Ravi I.
Published: December 2018

Background: Compared to the past, patients with sickle cell disease (SCD) currently live longer due to improvements in diagnosis and comprehensive care. Due to these advances, long-term chronic complications pose a greater challenge in the management of patients with SCD. In particular, sickle cell nephropathy (SCN) is associated with significant morbidity and mortality across all age groups. Furthermore, SCN is an understudied condition with relatively few symptoms and therefore requires close surveillance. In this review, we sought to explore the epidemiology, natural history, and treatment options for SCN with an emphasis on the pediatric population. Summary: SCN invariably begins in childhood with evidence of structural changes detected as early as infancy. These indolent changes can progress undetected to advanced chronic kidney disease by late adolescence or early adulthood. The risk factors for progression are not well defined, but significant albuminuria (which is also the most common presentation in childhood) is a key factor in progression. One of the main challenges in understanding SCN in children is the poor correlation between estimated and measured glomerular filtration rates. Another challenge is the lack of large-scale longitudinal studies that track the clinical outcomes of pediatric patients over time. Several studies aim to identify early biomarkers of SCN in children, as albuminuria presents only following significant chronic damage. The utility of angiotensin converting enzyme inhibitors and hydroxyurea in treating albuminuria is addressed here as well as novel treatments that may be of benefit.
Biomaterial Approaches to Modulate Reactive Astroglial Response
Authors: Zuidema Jonathan M. , Gilbert Ryan J. , Gottipati Manoj K.
Published: December 2018

Over several decades, biomaterial scientists have developed materials to spur axonal regeneration and limit secondary injury and tested these materials within preclinical animal models. Rarely, though, are astrocytes examined comprehensively when biomaterials are placed into the injury site. Astrocytes support neuronal function in the central nervous system. Following an injury, astrocytes undergo reactive gliosis and create a glial scar. The astrocytic glial scar forms a dense barrier which restricts the extension of regenerating axons through the injury site. However, there are several beneficial effects of the glial scar, including helping to reform the blood-brain barrier, limiting the extent of secondary injury, and supporting the health of regenerating axons near the injury site. This review provides a brief introduction to the role of astrocytes in the spinal cord, discusses astrocyte phenotypic changes that occur following injury, and highlights studies that explored astrocyte changes in response to biomaterials tested within in vitro or in vivo environments. Overall, we suggest that in order to improve biomaterial designs for spinal cord injury applications, investigators should more thoroughly consider the astrocyte response to such designs.
Lichenoid Reaction Pattern with Pseudoepitheliomatous Hyperplasia – A Rare Tattoo Reaction: A Case Report and Review of the Literature
Authors: Broussard-Steinberg Candace , Zemtsov Alexander , Strausburg Matthew , Zemtsov Gregory , Warren Simon
Published: December 2018

Pseudoepitheliomatous hyperplasia is a benign histologic reaction pattern that in rare cases can occur shortly after a tattooing procedure. We describe a case of pseudoepitheliomatous hyperplasia in two tattoos on the same patient 1 year after filling with the same batch of red ink.
Pericardium in Reconstructive Urologic Surgeries: A Systematic Review and Meta-Analysis
Authors: Hosseini Jalil , Hosseini Saeid , Hosseini Mohammad Ali , Rezaei Yousef
Published: December 2018

Introduction: The use of pericardium has been expanded into different surgical modalities; however, there are scarce data regarding the feasibility of the pericardium in reconstructive urologic surgeries. We systematically reviewed the literature on the effectiveness of the pericardial tissue for reconstructive urologic surgeries. Materials and Methods: PubMed and Scopus were searched online for evidence on the use of the pericardium in urologic surgeries. Through the methodology recommended by the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines, 38 of 4,071 studies were identified. Results: A total of 715 patients and 139 animals underwent reconstructive urologic surgeries using the pericardium. Bladder, urethral, and renal reconstructions were successful in 100% of the human cases. The rates of dissatisfaction, glans hypoesthesia, and penile shortening were comparable between the pericardial graft surgeries and the other operations during penile straightening, but there was a trend among the patients with pericardial grafts toward having a more penile curvature at follow-up (risk ratio [RR] 2.03, 95% CI 0.90–4.61, p = 0.09; I2 = 0%). Among the animal studies, there were 4 reports of penile reconstruction, 7 studies of bladder reconstruction, and 1 study of urethroplasty. Bladder reconstruction and urethroplasty were successful in 83 and 20% of the animals, respectively. The pooled result of the stimulated intracorporeal pressure 5 V significantly favored pericardial grafts during penile reconstruction (RR 2.61, 95% CI 1.26–3.97, p = 0.0002; I2 = 0%). Conclusions: Our systematic review demonstrates the feasibility of the pericardium, regardless of its type, in urologic surgeries. It, however, seems that urethral substitution needs further investigation. Given the lower cost, easier handling, and less immunogenicity of the pericardium, further studies are required to examine its pros and cons.
Left-Sided Atrial Septal Pouch as a Risk Factor of Cryptogenic Stroke: A Systematic Review and Meta-Analysis
Authors: Hołda Mateusz K. , Koziej Mateusz
Published: December 2018

Background: Despite some evidence of left-sided septal pouch (LSSP) involvement in the pathogenesis of cardioembolic stroke, the question of LSSP clinical significance still remains unsolved. In this study, we aimed to determine the association between the LSSP presence and cryptogenic stroke using meta-analytical approach. Methods: We performed a systematic review of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke control. Data were extracted and pooled into a meta-analysis. Results: Seven studies (400 cryptogenic stroke patients and 1,456 non-stroke controls) were included in the meta-analysis. A total of 138 LSSPs were identified among the cryptogenic stroke patients, with a pooled prevalence of 29.8% (95% CI 17.5–43.7%), and 268 LSSPs were identified in the non-stroke controls, with a pooled prevalence of 21.0% (95% CI 13.7–29.5%). After meta-analysis, the risk of cryptogenic stroke was higher in patients with an LSSP than in patients without LSSP (OR 1.52; 95% CI 1.15–2.00; p < 0.001). No significant heterogeneity was detected across the included studies (p > 0.05). Conclusion: Our meta-analysis demonstrated association between LSSP and cryptogenic stroke. In our univariate analysis, the risk of cryptogenic stroke is higher among patients with LSSP than in cases without the LSSP.
Over-the-Counter Herbal Weight Loss Supplements in Egypt: Label Claim, Microbiological and Pharmaceutical Quality, and Safety Assessments
Authors: Ahmed Nada , Nounou Mohamed Ismail , Abouelfetouh Alaa , El-Kamel Amal
Published: December 2018

Objectives: Nutraceuticals are advertised and sold with the label claim of being natural and safe herbal products. Due to the absence of clear regulations and guidelines for safety assessments of these products, nutraceuticals are commonly adulterated in order to increase sales. The objective of the current study was to design a comprehensive evaluation system to assess the safety, efficacy, authenticity according to label claim, and pharmaceutical quality of herbal slimming products in between 2015 and 2017. Methods: We designed a comprehensive assessment system to evaluate the safety, authenticity according to label claim, and pharmaceutical quality of slimming nutraceuticals. Six different popular products were evaluated (Zotreem Plus®, Zotreem Extra®, Malaysian Super Slim®, AB Slim®, Chinese Super Slim®, and Metabolites®). The pharmaceutical evaluation included analyzing the samples via high-performance liquid chromatography to determine any possible adulterants. Additionally, the products’ physical properties were assessed via pharmacopeial tests. Finally, a microbial evaluation and a cross-sectional observational retrospective prevalence study were conducted to assess the products’ safety and efficacy. ­Results: The tested products were found to be adulterated with unreported active pharmaceutical ingredients such as sibutramine, sildenafil, phenolphthalein, and orlistat. Furthermore, they contained heterogeneous amounts of adulterants and exhibited an unsatisfactory pharmaceutical and microbial quality. Finally, the observational survey conducted on users showed that high percentages of participants suffered from common side effects such as depression, diarrhea, and hypertension. Conclusions: These products threaten the health of consumers. There is a need to raise awareness of the lethal consequences of illegal nutraceuticals.
A formação do semioticista: experiência e paixão semióticas
Authors: Barros Diana Luz Pessoa de
Published: December 2018

Retomando as lembranças da experiência pessoal vivida em Paris nos seminários de Greimas e na convivência com ele, sobretudo, em dois momentos dos anos 1970, o texto menciona fatos que permitem contextualizar, de um lado, as atividades do grupo e o desenvolvimento da semiótica na França, e, de outro, a sua recepção e institucionalização em universidades da América Latina.
Itinerário intelectual de Greimas: o percurso da estrutura
Authors: Fiorin José Luiz
Published: December 2018

Este trabalho, depois de apresentar os objetivos e os fundamentos teóricos do trabalho lexicológico de Greimas, seja em suas teses de doutoramento, a principal e a subsidiária, seja em artigos escritos após sua defesa, mostra por que ele abandonou a lexicologia e criou uma semântica estrutural e uma semiótica. Analisando o percurso intelectual de Greimas, vê-se que nele estão sempre presentes as preocupações que estão na base de suas teses e primeiros trabalhos de lexicologia: busca de uma metodologia rigorosa; estudo da significação independente de outras disciplinas linguísticas; estudo estrutural e histórico das significações, sempre com base no princípio da imanência; prevalência da sincronia sobre a diacronia. O estudo do itinerário dos escritos de Greimas revela sua coerência intelectual ao longo de toda sua vida na busca de construir um estudo científico da significação.
Construir uma epistemologia para a semiótica em 1966
Authors: Parret Herman
Published: December 2018

Por meio de uma leitura parafrástica do livro Sémantique structurale (Greimas, 1966), examinamos a arquitetura conceitual dos quatro grandes patamares em que foi pensada a semiótica de Greimas nesta obra fundadora: o da linguagem-objeto, o da metalinguagem descritiva, o da linguagem metodológica e, por fim, o nível epistemológico no qual se inscrevem seus postulados não-analisados e indefiníveis. Nossos comentários se dirigem também à complementaridade dos procedimentos indutivo e dedutivo, bem como à centralidade da noção de percepção nas bases dessa teoria, a aproximar seus pressupostos da fenomenologia de Merleau-Ponty. Ao final, interpretamos a inspiração epistemológica de Sémantique structurale, sem dúvida "cientificamente vocacionada", no quadro mais amplo de uma axiologia que recobre um tipo específico de humanismo.
O último Greimas e o elogio da literatura
Authors: Martins Geraldo Vicente
Published: December 2018

Considerando que os estudos de A. J. Greimas, desde Semântica estrutural (1966), sempre reservaram espaço privilegiado à análise de textos literários, este artigo busca assinalar a sua importância para os desdobramentos que o edifício semiótico viria a ter a partir de Da imperfeição (1987), último livro de autoria individual do semioticista. Nessa perspectiva, destaca-se o olhar de Greimas sobre os fragmentos literários que toma como corpus no volume, em visada que acaba por se constituir como um elogio da literatura e da capacidade que, ao propiciar uma fruição estética a seus enunciatários, possui de chamar a atenção para outros modos de ver e (re)significar o mundo cotidiano dos indivíduos.
A psicossemiótica: um desejo inalcançável de Greimas
Authors: Darrault-Harris Ivan
Published: December 2018

O texto procura mostrar alguns ecos e algumas descobertas que demarcam o percurso (inalcançável?) de constituição da psicossemiótica, as condições de elaboração de uma metodologia de análise para um corpus totalmente novo. Interessada pela investigação semiótica do comportamento dos sujeitos em interação no espaço terapêutico, a psicossemiótica, de herança greimasiana, na medida em que se delineia também pela busca de um modelo universal da geração da significação no mundo humano, em especial o das crianças e adolescentes, mostra a pertinência das estruturas narrativas subjacentes e sustentadoras da atividade comportamental para o levantamento de resultados descritivos e analíticos no diagnóstico dos transtornos e patologias, na criação de estratégias terapêuticas originais.
Enunciação em meios digitais
Authors: Teixeira Lucia , Faria Karla , Azevedo Sandro Torres de
Published: December 2018

O artigo apresenta duas contribuições teóricas e analíticas, que demonstram a necessidade de reconceber a herança greimasiana para explicar a complexidade das relações enunciativas convocadas pela cibercultura. Na análise de jornais digitais, as estratégias enunciativas, ao debrear as categorias de pessoa, tempo e espaço no discurso, acolhem as experiências descentradas e não-lineares de espaço e tempo e a multiplicação de subjetividades. O leitor de jornais digitais não só comenta notícias, mas as faz circular em redes sociais e chega mesmo a produzi-las e enviá-las para publicação. Os papéis de enunciador e enunciatário perdem sua configuração clássica, pois não se trata mais da reversibilidade de papéis prevista em qualquer ato enunciativo, mas de um deslocamento das funções originais de cada uma dessas posições discursivas, tradicionalmente correspondentes às instâncias de produção e recepção do discurso. Propõe-se o conceito de proto-enunciador para designar os múltiplos papéis exercidos pelo enunciador do jornalismo disseminado na rede digital. Já a análise da cena comunicativa estabelecida nas experiências vividas em ações publicitárias que se utilizam dos recursos tecnológicos da realidade aumentada permite identificar um processo complexo de confusão entre os mecanismos de debreagem e embreagem, tais como o define a semiótica discursiva, pois a sobreposição das categorias de pessoa, tempo e espaço, numa zona que hibridiza o concreto e o virtual, tanto projeta o sujeito no enunciado quanto neutraliza essa projeção, ao fazê-lo retornar à enunciação. O mecanismo de projeção de categorias enunciativas nesse objeto foi nomeado multibreagem.
Testemunho e veridicção
Authors: Filinich María Isabel
Published: December 2018

A consideração de uma prática discursiva particular, o testemunho de um sobrevivente, assim como o papel da veridicção (o dizer verdadeiro) e da certeza (o crer certo), no âmbito dessa prática, é aqui realizada à luz do pensamento de Greimas sobre o ato de crer. Com o propósito de refletir sobre a enunciação testemunhal e o regime de credibilidade que esse discurso instaura, analisa-se a polêmica causada pela aparição do testemunho de Rigoberta Menchú, sobre a verificação de algumas circunstâncias que rodearam os fatos relatados e de sua legitimidade como testemunha ocular. A revisão desse questionamento permite extrair algumas conclusões sobre o regime de autenticação ou credibilidade próprio do testemunho (diferente daquele que instaura o discurso científico); assim a comunicação de uma experiência vivida, o lugar do corpo como fiador e da marca deixada pelos acontecimentos, o valor do eu como instância coletiva, os traços da oralidade, o caráter assertivo da suposição, a ética, implicada, etc., são alguns dos traços que configuram o regime de credibilidade que confere a eficácia ao discurso testemunhal.
Por que Greimas?
Authors: Harkot-de-La-Taille Elizabeth
Published: December 2018

Um número reduzido de fatores influencia nossas escolhas acadêmicas. Enquanto estudantes, todos temos inclinações, tais como as disciplinas preferidas; expectativas, por exemplo, no tipo de qualificação que queremos desenvolver; um estilo de pensamento, que contribui para que um se sinta confortável, digamos, com semântica cognitiva, mas não com outras abordagens. Esses fatores orientam nossas escolhas, e contribuem com a construção de nosso repertório. Porém, isso não é tudo. O imponderável pode surgir e reforçar ou redirecionar nossas escolhas anteriores. Por acaso, um dia me deparei com Semântica estrutural, de Greimas, livro que não apenas acalmou minhas inquietações estudantis, mas também apresentou novas perspectivas, entre as quais o “mundo natural” como tendo papel no “nascimento” do sentido, e uma discussão inicial sobre a complexidade do conceito de figuratividade, tanto no “mundo natural”, como no discurso. A primeira, figuratividade no “mundo natural”, dizia respeito à informação que os cinco sentidos nos fornecem sobre o mundo, enquanto a remetia às imagens evocadas no discurso. Aqui, a complexidade do conceito de figuratividade é destacada e apresentada por dois pontos de vista. Ademais, sugere-se que a figuratividade é transversal ao percurso gerativo do sentido, proporcionando a “energia” necessária para a conversão de um nível a outro superior (em direção à superfície). A intenção de encorajar tal debate subjaz a maior parte desta contribuição.
Sem Greimas, com Greimas, após Greimas, cem Greimas
Authors: Mancini Renata
Published: December 2018

Motivada pela convicção de que a maior homenagem que se pode fazer a Greimas é mostrar como sua proposta frutificou em termos de longevidade, vitalidade e alcance, apresento neste trabalho um breve relato do meu percurso de pesquisa, desde os primeiros contatos com a teoria semiótica até os desenvolvimentos teóricos propostos coletivamente dentro do LabS-Sedi. Dentre as questões apresentadas em linhas gerais, destacam-se: a leitura tensiva das modalidades veridictórias; algumas questões centrais do projeto sobre traduções intersemióticas e sua formulação em torno da recriação de um projeto enunciativo; um tratamento em graus da concessividade; e apontamentos para o que futuramente se desdobrará no projeto linguagens híbridas. Com o relato, espero contribuir para mostrar que a abordagem greimasiana dos fenômenos de construção de sentido renova-se no acolhimento dos novos desafios à teoria que, graças a sua coerência, mantém-se robusta e produtiva.
Semântica estrutural e poética do sentido
Authors: Bertrand Denis
Published: December 2018

Greimas atribuía sua opção pela língua francesa à “escrita de aço de Flaubert”. De igual modo, o edifício conceitual e analítico de Semântica estrutural dá à forma do conteúdo uma tal materialidade que esta também pode ser denominada “de aço”. Interrogaremos essa sensibilidade material que orienta a reconstrução científica do semantismo e a consideraremos uma poética. Esse procedimento libera efetivamente as potencialidades interpretativas do texto dos enclaves em que se encontra sua essência, tornando-as, então, formalmente descritíveis – ao mesmo tempo que assume sua parcela inevitável de elipse e imperfeição. Sobre essa base, interrogaremos, no centro de Semântica estrutural, a passagem da construção analítica à expressão literária e, particularmente, ao imaginário de Bermanos estudado por Tashun Yücel e, daí, à introdução de Sobre o sentido, que surgiria alguns anos mais tarde, ela própria intitulada “Sobre o sentido”.
O estilo e o ator da enunciação: Greimas na contemporaneidade
Authors: Discini Norma
Published: December 2018

Os fundamentos da semiótica trazidos à luz por Algirdas Julien Greimas serão cotejados com os desdobramentos da teoria postulados por Claude Zilberberg, enquanto analisamos mecanismos de construção do sujeito da enunciação, enunciador e enunciatário. Examinado como ator provido de determinado corpo, esse sujeito – que, sintático e semântico, é aspectualizado ao apresentar-se de modo sensível no interior dos enunciados – será apreendido do interior da novela gráfica (HQ). A partir daí, dois tipos de sincretismo verbovisual – por mescla e por fusão – apontarão para corpos perfectivos ou imperfectivos, na relação estabelecida entre pessoa, tempo e espaço percebidos desde as profundidades figurais.
História das ideias semióticas: entre cronistas e inovadores
Authors: Portela Jean Cristtus
Published: December 2018

O artigo consiste em um estudo epistemológico e histórico sobre a historiografia da semiótica do discurso e tem como objetivo propor uma leitura crítica do modo como os semioticistas ocuparam-se da história da semiótica. A partir de reflexões desenvolvidas no âmbito da história das ideias linguísticas (S. Auroux) e no quadro dos estudos históricos e conceituais da semiótica (J.-C. Coquet, M. Arrivé, A. Hénault, E. Landowski, C. Zilberberg, entre outros), analisam-se abordagens historiográficas sobre a semiótica do discurso, no que diz respeito aos seus objetivos, à sua metodologia e ao seu objeto, distinguindo dois tipos de fazeres historiográficos correntes até o momento entre os semioticistas (aquele dos cronistas e aquele dos inovadores) e, ao mesmo tempo, propõe os fundamentos mínimos de uma meta-historiografia de inspiração semiótica.
A semiótica da escultura
Authors: Pietroforte Antonio Vicente Seraphim
Published: December 2018

Ao que tudo indica, a semiótica narrativa e discursiva proposta por Greimas e colaboradores tem, além de sua vocação teórica, tendência de ser testada em aplicações analíticas nos mais variados tipos de discurso e sistemas de significação. Desde os primeiros trabalhos de divulgação científica, isso está presente: em Introdução à semiótica narrativa e discursiva, de J. Courtés – tradução para o Português de 1979 –, há análises do conto de fadas da Cinderela; em Semiótica da narrativa, de N. Everaert-Desmedt – tradução para o Português de 1984 –, há análises dos Labirintos de Espelhos e Trens Fantasmas dos parques de diversões. Ora, essa vocação, na análise das artes plásticas, certamente tem em Jean-Marie Floch um de seus mais criativos representantes; Floch é célebre por suas aplicações da semiótica no estudo do cinema, do teatro, da pintura, da fotografia, da história em quadrinhos, da arquitetura, do discurso publicitário. Quanto à análise da escultura, comparada à análise dos demais sistemas de significação, pouco foi dito. Desse modo, buscando preencher essas lacunas, nosso trabalho vai ao encontro da aplicação da semiótica à análise da escultura em duas frentes: a escultura enquanto texto; a escultura enquanto objeto de valor.
Editorial
Authors: Crippa Giulia
Published: December 2018

InCID: Revista de Ciência da Informação e Documentação, Ribeirão Preto, v. 9, n. 2, p. 1-3, set. 2018/fev. 2019
Gestão por competências em bibliotecas universitárias
Authors: Valeriano Renata Bezerra , Garske Lindalva Maria Novaes
Published: December 2018

O estudo apresenta as bibliotecas universitárias como organizações que ao longo do tempo tornaram-se extremamente dependentes das novas tecnologias da informação para oferecerem serviços e produtos em harmonia com as necessidades informacionais de seus usuários. Neste contexto, aponta-se com base na literatura científica quais são as competências necessárias ao pessoal que atua neste ambiente cada vez mais desenvolvido e dinâmico. Tem como objetivo identificar como ocorre a gestão por competências nas bibliotecas da Universidade Federal de Mato Grosso (UFMT), com o propósito de subsidiar a gestão de pessoas neste setor. O estudo é de abordagem qualitativa. Realizou-se entrevistas com três dos gestores destas bibliotecas no intuito de identificar como ocorre a gestão por competências nestas. As respostas dos gestores demonstram que a gestão por competências nas bibliotecas ainda não é efetiva, uma vez que não contempla a todos os servidores das bibliotecas, devido ao número insuficiente de servidores com nível de instrução compatível com as atividades a serem desempenhadas e a necessidade da contratação de novos servidores com formação intelectual e cultural para atuar em bibliotecas.
Preservação de memória, o qbit e a criptografia quântica
Authors: Pimentel Sobrinho Alvaro Caetano
Published: December 2018

Este artigo apresenta uma análise sobre a preservação da memória com a utilização dos dispositivos tecnológicos e com a introdução do conceito do bit quântico (q-bit). A proposta considera a possibilidade de transmitir e preservar a memória utilizando conceitos da física quântica, estudos sobre a mediologia e a angelética e as possibilidades de armazenamento com o uso dos meios magnéticos atuais. Há, ainda, uma breve explanação sobre as possibilidades de segurança da preservação de memória com a utilização de criptografia quântica.
Bases teóricas da gestão da informação
Authors: Monteiro Samuel Alves , Duarte Emeide Nóbrega
Published: December 2018

Este artigo discorre sobre os principais acontecimentos históricos e as iniciativas que deram origem à gestão da informação. Apresenta o progresso conceitual do tema, partindo da discussão basilar sobre as significações iniciais para os termos informação e gestão, ao discutir a respeito das relações interdisciplinares da gestão da informação. Caracteriza-se como estudo exploratório, com abordagem qualitativa, do tipo bibliográfico. A gestão da informação contemporânea torna a disciplina fundamental para o desenvolvimento de uma nova - a Gestão do Conhecimento - cujo objetivo se diferencia do da gestão da informação por pensar para além da gestão da informação. A partir disso, considera-se que o objetivo principal deste estudo foi atingido, porque deu subsídios teóricos para o desenvolvimento de pesquisas futuras em gestão da informação.
Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring
Authors: Tanwar Vineeta , Adelstein Jeremy M. , Grimmer Jacob A. , Youtz Dane J. , Katapadi Aashish , Sugar Benjamin P. , Falvo Michael J. , Baer Lisa A. , Stanford Kristin I. , Wold Loren E.
Published: December 2018

Background

Particulate matter (particles < 2.5 μm [
PM
2.5
]) exposure during the in utero and postnatal developmental periods causes cardiac dysfunction during adulthood. Here, we investigated the potential priming effects of preconception exposure of
PM
2.5
on cardiac function in adult offspring.

Methods and Results

Male and female friend leukemia virus b (FVB) mice were exposed to either filtered air (
FA
) or
PM
2.5
at an average concentration of 38.58 μg/m
3
for 6 hours/day, 5 days/week for 3 months. Mice were then crossbred into 2 groups: (1) 
FA
male
×
FA
female
(both parents were exposed to
FA
preconception) and, (2)
PM
2.5male
×
PM
2.5female
(both parents were exposed to
PM
2.5
preconception). Male offspring were divided: (1) preconception
FA
(offspring born to
FA
exposed parents) and, (2) preconception
PM
2.5
(offspring born to
PM
2.5
exposed parents) and analyzed at 3 months of age. Echocardiography identified increased left ventricular end systolic volume and reduced posterior wall thickness, reduced %fractional shortening and %ejection fraction in preconception
PM
2.5
offspring. Cardiomyocytes isolated from preconception
PM
2.5
offspring showed reduced %peak shortening, −dL/dT,
TPS
90 and slower calcium reuptake (tau). Gene and protein expression revealed modifications in markers of inflammation (
IL
‐6,
IL
‐15,
TNF
α,
NF
қB,
CRP
,
CD
26E,
CD
26P, intercellular adhesion molecule 1, and monocyte chemoattractant protein‐1) profibrosis (collagen type III alpha 1 chain), oxidative stress (
NOS
2), antioxidants (Nrf2,
SOD
, catalase), Ca
2+
regulatory proteins (
SERCA
2a, p‐
PLN
,
NCX
), and epigenetic regulators (Dnmt1, Dnmt3a, Dnmt3b, Sirt1, and Sirt2) in preconception
PM
2.5
offspring.

Conclusions

Preconception exposure to
PM
2.5
results in global cardiac dysfunction in adult offspring, suggesting that abnormalities during development are not limited to the prenatal or postnatal periods but can also be determined before conception.
Distribution and new synonymy in European biting midges of the genus Dasyhelea Kieffer (Diptera: Ceratopogonidae)
Authors: DOMINIAK PATRYCJA , SZADZIEWSKI RYSZARD
Published: December 2018

We present a review of distribution and new synonymy of the 63 valid species of biting midges in the genus Dasyhelea occurring in Europe. New distribution records, mostly from Ukraine and Romania, are provided. Dasyhelea alonensis (Strobl), D. mayor (Strobl), D. decoratissima (Strobl) and D. bilineata Goetghebuer are redescribed and interpreted. Seventeen NEW SYNONYMS are proposed for the following species: Dasyhelea modesta Winnertz (= D. inclusa Kieffer), D. mayor (Strobl) (= D. aperta Goetghebuer & Timon David, D. wuelkeri Mayer), D. bilobata Kieffer (= D. luteiventris Goetghebuer, D. spiralis Remm), D. bilineata Goetghebuer (= D. insignipalpis Kieffer, Tetraphora saxicola Edwards, D. geleiana Zilahi-Sebess, D. montana Zilahi-Sebess, D. lithotelmatica Strenzke, D. tecticola Remmert, Culicoides dieuzeidei Vaillant, D. karelica Glukhova & Brodskaya), D. dampfi Kieffer (= D. estonica Kieffer), D. turficola Kieffer (= D. malibui Yu), D. turanicola Remm & Nazarmukhamedov (= D. serrata Navai), D. corinneae Gosseries (= D. chonetus Yu & Zou). Dasyhelea furva Remm is removed from synonymy with D. bifida Zilahi-Sebess and D. alonensis (Strobl) removed from synonymy with D. flavoscutellata (Zetterstedt). Ceratopogon aristolochiae Rondani is transferred from the genus Dasyhelea to the genus Forcipomyia (comb. nov.) and recognized as a new senior synonym of Forcipomyia brevicubita Goetghebuer and F. pontica Remm (syn. nov.). Lectotypes are designated for Dasyhelea alonensis (Strobl), D. mayor (Strobl), D. decoratissima (Strobl) and Forcipomyia aristolochiae (Rondani). Dasyhelea longituba Kieffer, D. strigosa Kieffer, D. neobifurcata Wirth and D. paragrata Remm are excluded from the European fauna. In addition, we provide a list of 17 doubtful species (nomina dubia) described from Europe and one nomen nudum.
Two new species of Ranitomeya (Anura: Dendrobatidae) from eastern Amazonian Peru
Authors: PEREZ-PEÑA PEDRO E. , CHAVEZ GERMAN , TWOMEY EVAN , BROWN JASON L.
Published: December 2018

We describe two new species of Ranitomeya (family Dendrobatidae), R. yavaricola sp. nov. and R. cyanovittata sp. nov., from Peru. Ranitomeya yavaricola sp. nov. is morphologically similar to certain other species of Ranitomeya (in particular R. flavovittata), but the new species can be easily distinguished from all other species of Ranitomeya based on its unique limb coloration: solid bronze without black markings. Despite having searched in numerous localities throughout this region, we have found the new species at only a single locality near the confluence of the Yavarí and Yavari-Mirin rivers. Based on acoustic and molecular data, the new species is a member of the vanzolinii group, and is sister to the second new species, R. cyanovittata. Ranitomeya cyanovittata sp. nov. is only known from a single locality in the Sierra del Divisor in Amazonian Peru. This species can be easily distinguished from the other species of Ranitomeya by a unique coloration pattern that consists of just two colors: black background with blue lines or reticulations.
Taxonomic notes and Corrigendum for the manuscript entitled “Ichneumonid wasps of the subfamily Mesochorinae (Hymenoptera: Ichneumonidae): new replacement names, combinations and an updated key to the World genera” ARAUJO et al. (2018), Zootaxa, 4521: 052–060.
Authors: ARAUJO RODRIGO O.
Published: December 2018

Mesochorinae is a widely distributed subfamily of ichneumonid wasps with approximately 900 described species (Yu et al., 2012), of which almost 90% belong to the cosmopolitan genus Mesochorus Gravenhorst (Broad et al., 2018). Since it is a very large genus, it has become a group of complex taxonomy and with numerous taxonomic conflicts (Araujo et al., 2018). Recent efforts were made aiming to resolve nomenclature problems present within Mesochorus (see Araujo & Vivallo, 2015; Kittel, 2016; Araujo et al. 2018). Specifically, Araujo & Vivallo (2015) and Araujo et al. (2018) proposed a total of 19 replacement names, of which two became primary homonyms of existing names (listed below) and seven were invalid, as Kittel (2016) and, in one case, Schwenke (2002), had previously proposed respective replacement names. Furthermore, Araujo et al. (2018) published an identification key for the World genera of Mesochorinae which includes Incurvarion Kasparyan. However, this genus was implicitly synonymized with Neurogenia Roman (Ctenopelmatinae: Perilissini) when Reshchikov et al. (2014) transferred the type (and only included) species, I. gorochovi Kasparyan, to Neurogenia. To resolve the taxonomic conflicts that remain within the subfamily Mesochorinae, seven new synonymies and two replacement names are proposed herein, together with a corrigendum for the identification key proposed by Araujo et al. (2018).
Description of the larvae of Faula jaliscoensis (Delgado & Navarrete-Heredia) (Coleoptera: Scarabaeidae: Melolonthinae) from Nayarit, Mexico
Authors: LUGO-GARCÍA GABRIEL A. , CUATE M. VÍCTOR A. , CORTEZ-ISIORDIA KENEDY A.
Published: December 2018

The larvae of Faula jaliscoensis (Delagado & Navarette-Heredia, 2004) (Coleoptera: Scarabaeidae: Melolonthinae: Macrodactylini) is described based in specimens collected in a sugarcane (Saccharum officinarum Linnaeus; Poaceae) field in Nayarit, Mexico. Diagnostic structures are illustrated and the differences between other described larvae of Faula Blanchard, 1850 are discussed. Faula was recently removed from synonymy with Ceraspis LePeletier & Serville, 1828 by Fuhrmann & Vaz-de-Mello (2017), with the following species occur in Mexico: Faula centralis (Sharp, 1877), F. jaliscoensis (Delagado & Navarette-Heredia, 2004), F. mexicana Harold, 1863, F. oaxacaensis (Delgado, 2001), and F. pilatei Harold, 1863 (Evans & Smith 2009). The objectives of this study are to describe the third instar of F. jaliscoensis and compare it with other described species of Faula in Mexico.
A new species of Parafimbrios from northern Vietnam (Squamata: Xenodermatidae)
Authors: ZIEGLER THOMAS , NGO HAI NGOC , VAN PHAM ANH , NGUYEN THAM THI , LE MINH DUC , NGUYEN TRUONG QUANG
Published: December 2018

A second species of the previously monotypic snake genus Parafimbrios is described from Lai Chau Province, northern Vietnam, based both on molecular and morphological evidences. Parafimbrios vietnamensis sp. nov. is characterized by a combination of the following characters: 1) rostral laterally with two raised, curved edges; the upper one, together with a horizontal curved ridge of tissue, separate the rostral from the internasals; 2) nasal in contact zone with rostral with curved raised edge; 3) nasal in contact zone with supralabials each with two small oblique, curved raised edges located above first and second as well as above second and third supralabials; 4) suture between the internasals much longer than that between the prefrontals; 5) supralabials 8, with the first four bearing raised edges; 6) infralabials 7; mental and anterior three to four infralabials with raised edges; 7) temporals 4+4–5; 8) 35–33–29 dorsal scale rows; 9) laterally rounded ventrals 164; 10) unpaired subcaudals 49; 11) total length of at least 266 mm in males (with a tail length of 44 mm, and a tail / total length ratio of 0. 165). This discovery brings the total number of taxa of the family Xenodermatidae in Vietnam to seven species: Achalinus ater, A. rufescens, A. spinalis, Fimbrios klossi, F. smithi, Parafimbrios lao, and P. vietnamensis.