bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoscale Biomolecular Structures on Self‐Assembled Monolayers Generated from Modular Pegylated Disulfides
Authors: Wong Lu Shin , Janusz Stefan J. , Sun Shuqing , Leggett Graham J. , Micklefield Jason
Published: September 2010

A solid‐phase synthetic strategy was developed that uses modular building blocks to prepare symmetric oligo(ethylene glycol)‐terminated disulfides with a variety of lengths and terminal functionalities. The modular disulfides, composed of alkyl amino groups linked by an amide group to oligoethylene chains were used to generate self‐assembled monolayers (SAMs), which were characterised to determine their applicability for biomolecular applications. X‐ray photoelectron spectroscopy (XPS) of the SAMs obtained from these molecules demonstrated improved stability towards displacement by 16‐hexadecanethiol, while surface plasmon resonance (SPR) analyses of SAMs prepared with the hydroxy‐terminated oligoethylene disulfide showed equal resistance to non‐specific protein adsorption in comparison to 11‐mercaptoundecyl tri(ethylene glycol). SAMs made from these adsorbates were amenable to nanoscale patterning by scanning near‐field photolithography (SNP), facilitating the fabrication of nanopatterned, protein‐functionalised surfaces. Such SAMs may be further developed for bionanotechnology applications such as the fabrication of nanoscale biological arrays and sensor devices.
ChemInform Abstract: A Novel In3O16 Fragment in Cs3In3(PO4)4.
Authors: Zatovsky Igor V. , Baumer Vyacheslav N. , Strutynska Nataliya Yu. , Slobodyanik Nikolay S. , Shishkin Oleg V.
Published: September 2010

Single crystals of the new title compound are obtained from a melt of Cs3P3O9, Cs2CO3, In2O3, and CuO (Pt crucible, 1223 K, 3 h).
ChemInform Abstract: Cs6Nb4Se22 and K12Nb6Se35.3: Two New Compounds Containing the M4O22 Building Block.
Authors: Krizan Jason W. , Pulido Sergio H. , Wehrhan Sarah E. , Chan Benny C.
Published: September 2010

The title compounds are prepared by reaction of Nb, Se, and Cs2Se2 or K2Se2 (evacuated silica tube, 773 K, 75 and 120 h, resp.).
ChemInform Abstract: Structural and Superconducting Properties of YBaCuO Superconductors at Different Atomic Compositions.
Authors: Topal Ugur , Akdogan Mustafa
Published: September 2010

Y—Ba—Cu—O superconductors with a transition temperature of above 90 K are synthesized without the necessity of any thermal treatment under oxygen from mixtures of Y2O3, BaCO3, and CuO at a nominal composition of YBaCu2Ox (900—1000 °C, 20 h).
ChemInform Abstract: Sunlight Highly Photoactive Bi2WO6—TiO2 Heterostructures for Rhodamine B Degradation.
Authors: Colon G. , Lopez S. Murcia , Hidalgo M. C. , Navio J. A.
Published: September 2010

Highly efficient Bi2WO6—TiO2 heterostructures are synthesized by hydrothermal reaction of Na2WO4, Bi(NO3)3, and TiO2 in the presence of NEt3 (H2O, 140 °C, autoclave, 20 h) and subsequent calcination (300 °C, 4 h).
ChemInform Abstract: A Chiral Solvent Effect on Asymmetric Organocatalysis.
Authors: North Michael , Villuendas Pedro
Published: September 2010

Asymmetric proline‐catalyzed aldol reaction of enolizable ketones with aromatic aldehydes proceeds smoothly in propylene carbonate as solvent.
ChemInform Abstract: Asymmetric Michael Addition of Ketones to Nitroolefins Catalyzed by a New Chiral Catalyst.
Authors: Wang Lian‐Jun , Hu Feng‐Feng
Published: September 2010

A new chiral catalyst is presented for the asymmetric Michael addition of ketones to nitroolefins.
ChemInform Abstract: Ni‐Catalyzed Borylative Diene—Aldehyde Coupling: The Remarkable Effect of P(SiMe3)3.
Authors: Cho Hee Yeon , Morken James P.
Published: September 2010

The nickel‐catalyzed coupling of aldehyde and diene is accomplished in a regio‐ and stereoselective fashion employing a stoichiometric amount of bis(pinacolato)diboron.
ChemInform Abstract: Sm(II)‐Mediated Reduction in Water: Importance of the Additive in the Proportionation of SmCl3 and Sm.
Authors: Matsukawa S. , Ichikawa K. , Ogura Y.
Published: September 2010

Addition of DMA enhances the reactivity of the one‐electron reduction in the SmCl3—Sm system in water.
ChemInform Abstract: Lanthanum Tricyanide Catalyzed Acyl Silane—Ketone Benzoin Additions and Kinetic Resolution of Resultant of α‐Silyloxyketones.
Authors: Tarr James C. , Johnson Jeffrey S.
Published: September 2010

In the presence of La(CN)3 a wide range of ketones reacts with acyl silanes to afford α‐silyloxyketones.
ChemInform Abstract: Copper‐Catalyzed γ‐Selective and Stereospecific Allyl—Aryl Coupling Between (Z)‐Acyclic and Cyclic Allylic Phosphates and Arylboronates.
Authors: Ohmiya Hiroshi , Yokokawa Natsumi , Sawamura Masaya
Published: September 2010

Copper‐catalyzed reaction of (Z)‐allylic phosphonates, e.g. (I), with arylboronates (II) provides coupling products with excellent (E)‐stereoselectivity and absolute γ‐regioselectivity in most cases.
ChemInform Abstract: Nucleophilic Iron Catalysis in Transesterifications: Scope and Limitations.
Authors: Magens Silja , Plietker Bernd
Published: September 2010

It is found that the Fe catalyst shown in the scheme efficiently promotes the transesterification of a wide range of esters with diverse alcohols.
ChemInform Abstract: One‐Pot Synthesis of 1,4‐Dihydropyridine and Polyhydroquinoline Derivatives via L‐Proline Catalyzed Hantzsch Multicomponent Reaction under Ultrasound Irradiation.
Authors: Guo Shengrong , Yuan Yanqin
Published: September 2010

The use of L‐proline as catalyst in symmetrical and unsymmetrical Hantzsch 1,4‐DHP synthesis is studied.
ChemInform Abstract: Activation of Fmoc‐Protected N,O‐Acetals Using Trimethylsilyl Halides: Mechanistic and Synthetic Studies.
Authors: Boaz Nicholas C. , Bair Nathaniel C. , Le Thanh T. , Peelen Timothy J.
Published: September 2010

Treatment of the Fmoc‐protected amino alcohol (II), a “so‐called” N,O‐acetal, with TmsCl results in formation of a chloromethylcarbamate intermediate, which reacts with enamines to give β‐amino ketenes and aldehydes.
ChemInform Abstract: N,N′‐Diarylsquaramides: General, High‐Yielding Synthesis and Applications in Colorimetric Anion Sensing.
Authors: Rostami Ali , Colin Alexis , Li Xiao Yu , Chudzinski Michael G. , Lough Alan J. , Taylor Mark S.
Published: September 2010

A simple, efficient, and widely applicable method is reported.
ChemInform Abstract: A Highly syn‐Selective Nitroaldol Reaction Catalyzed by CuII‐Bisimidazoline.
Authors: Cheng Liang , Dong Jiaxing , You Jingsong , Gao Ge , Lan Jingbo
Published: September 2010

Aliphatic aldehydes afford the products with the higher diastereoselectivity than the aromatic ones.
ChemInform Abstract: One‐Pot Three‐Component Solvent‐Free Syntheses of n‐Alkyl‐Bridged N,N,N′,N′‐Tetra(2‐hydroxybenzyl)diamines (II) and N,N‐Bis(2‐hydroxybenzyl) Amines (VI).
Authors: Riisioe Antti , Wichmann Oula , Sillanpaeae Reijo
Published: September 2010

Isolation of the products can be a problem.
ChemInform Abstract: Solvent‐Free Michael Addition Between EMME and Secondary Amine under Focused Microwave Irradiation.
Authors: Kim Ki Won , Lee Hee Jung , Jo Jeong Im , Kwon Tae Woo
Published: September 2010

The Michael‐type reaction of amines with diethyl ethoxymethylenmalonate (EMME) (I) is described.
ChemInform Abstract: Enantioselective Reduction of Acetophenone Analogues Using Carrot and Celeriac Enzymes System.
Authors: Liu Xiang , Pan Zheng Guang , Xu Jian He , Li He Xing
Published: September 2010

In contrast to the yields, the enantioselectivity is not influenced by steric or electronic effects.
ChemInform Abstract: Palladium‐Catalyzed Selective Alkoxycarbonylation of α,β‐Unsaturated Amides: A Novel Approach Toward New ω‐Amido Esters and N‐Substituted Cyclic Succinimides.
Authors: Suleiman Rami , El Ali Bassam
Published: September 2010

The first step provides ω‐amido esters, which cyclize to the corresponding succinimides upon treatment with calcium hydride in DMF.
ChemInform Abstract: Indium Modified Mesoporous Zeolite AlMCM‐41 as a Heterogeneous Catalyst for the Knoevenagel Condensation Reaction.
Authors: Katkar Santosh S. , Lande Machhindra K. , Arbad Balasaheb R. , Rathod Sandip B.
Published: September 2010

The indium‐modified mesoporous zeolite AlMCM‐41 is used as heterogeneous catalyst for the Knoevenagel reaction of aromatic aldehydes (I) and activated methylene compounds (II).
ChemInform Abstract: Synthesis of Sterically Encumbered Biaryls Based on a “Copper(I)‐Catalyzed Arylation/[3 + 3] Cyclocondensation” Strategy.
Authors: Langer Peter , et al. et al.
Published: September 2010

A variety of 5‐arylsalicylates is prepared by a formal [3+3] cyclization reaction of silyl enol ethers (V) with 1,3‐bis(silyloxy)‐1,3‐dienes mediated by TiCl4.
ChemInform Abstract: Sonogashira Cross‐Coupling of Arenediazonium Salts.
Authors: Fabrizi Giancarlo , Goggiamani Antonella , Sferrazza Alessio , Cacchi Sandro
Published: September 2010

The title compounds are alkynylated by a domino iododediazoniation/Sonogashira cross‐coupling using various terminal alkynes and a variety of functionalities is tolerated for both types of substrates.
ChemInform Abstract: Synthesis of 3,3′‐Diaryl‐Substituted 2,2′‐Diamino‐1,1′‐binaphthyl and Its Derivatives.
Authors: Yoshimura Masahiro , Muraoka Toshimitsu , Nakatsuka Hiroshi , Huang Hanmin , Kitamura Masato
Published: September 2010

Each step affords the product with < 90% yield.
ChemInform Abstract: Facile Synthesis of Benzofulvene Derivatives from Baylis—Hillman Adducts: In‐Mediated Barbier Reaction Combined with Pd(0)‐Catalyzed Intramolecular Heck‐Elimination Cascade.
Authors: Kim Ko Hoon , Kim Sung Hwan , Park Bo Ram , Kim Jae Nyoung
Published: September 2010

Precursors (V), (VIII), and (XI), derived from Baylis—Hillman adducts via bromination, Barbier reaction with aldehydes and acetylation, are subjected to Pd‐catalyzed conditions A) or B).
ChemInform Abstract: Facile Conversion of Epoxides to Thiiranes with Ammonium Thiocyanate Catalyzed with Etidronic Acid.
Authors: Wu Liqiang , Wang Yongxue , Yan Fulin , Yang Chunguang
Published: September 2010

Thiiranes are formed from epoxides when treated with NH4SCN in boiling THF using etidronic acid as catalyst.
ChemInform Abstract: Synthesis of Bis(tetronic acid)s via Double Dieckmann Condensation.
Authors: Thetiot‐Laurent Sophie A.‐L. , Nadal Brice , Le Gall Thierry
Published: September 2010

Starting from dimethyl‐L‐tartrate, the convenient two‐step sequence allows the preparation of enantiopure target compounds (IV) via double Dieckmann condensation of esters (III).
ChemInform Abstract: IBX, an Excellent Reagent for Oxidation of 2‐Furyl Carbinols: A New and General Method for Preparation of Furyl Ketones.
Authors: Singh Vishwakarma , Singh Vikrant
Published: September 2010

Unlike other oxidizing agents such as MnO2, PCC, or Dess—Martin periodinane, IBX oxidizes 2‐furylcarbinols smoothly and without rearrangement‐derived side products.
ChemInform Abstract: Synthesis of 2,5‐Disubstituted Tetrahydrofurans from Organozinc Halides and Lactones.
Authors: Huang Dan Feng , Wang Hai Feng , Xu Chang Ming , Niu Teng , Hu Yu Lai
Published: September 2010

Acetoxy derivatives of lactols, derived from lactones (I) and (V) react with organozinc halides in the presence of Lewis acids to produce substituted tetrahydrofurans CeCl3 shows the best reactivity.
ChemInform Abstract: Arylation of Sensitive 1‐(Pyrrolidin‐1‐yl)‐diazen‐1‐ium‐diolate in Ionic Liquids.
Authors: Velazquez Carlos A. , Lynn Geoffrey M. , Kumar Vineet , Keefer Larry K. , Malhotra Sanjay V.
Published: September 2010

Stability and reactivity of title compound (I) in different solvents are studied.
ChemInform Abstract: Straightforward Assembly of the Octahydroisoquinoline Core of Morphinan Alkaloids.
Authors: Dunet Julie , Lebeuf Raphael , Bose Gopal , Robert Frederic , Landais Yannick
Published: September 2010

The octahydroisoquinoline core of morphinan is prepared with high diastereoselectivity.
ChemInform Abstract: α‐Arylation of 3‐Aryloxindoles.
Authors: Mai Cheng‐Kang , Sammons Matthew F. , Sammakia Tarek
Published: September 2010

A variety of oxindoles bearing an all‐carbon stereocenter at position 3 (III), (V), (VIII) and (X) is prepared by Pd‐catalyzed α‐arylation of the corresponding 3‐aryloxindoles.
ChemInform Abstract: Gold‐Catalyzed Intramolecular Indole/Alkyne Cyclization Cascades Through a Heterolytic Fragmentation: 1,5‐Indole Migration and Allenylation.
Authors: Li Guijie , Liu Yuanhong
Published: September 2010

Treatment of alkynylated indoles of type (I), (III), and (V) with Au catalysts results in efficient formation of 3‐allenyl indoles via a new cyclization/heterolytic fragmentation/elimination cascade.
ChemInform Abstract: A Novel Diastereoselective Multicomponent Cascade Reaction.
Authors: Kriis Kadri , Ausmees Kerti , Pehk Tonis , Lopp Margus , Kanger Tonis
Published: September 2010

An efficient, one‐step multicomponent reaction to yield the tetrasubstituted azabicycloheptane derivatives (V) or (VIII) is developed.
ChemInform Abstract: Pt(IV)‐Catalyzed Hydroamination Triggered Cyclization: A Strategy to Fused Pyrrole[1,2‐a]quinoxalines, Indolo[1,2‐a]quinoxalines, and Indolo[3,2‐c]quinolines.
Authors: Patil Nitin T. , Kavthe Rahul D. , Shinde Valmik S. , Sridhar Balasubramanian
Published: September 2010

The Pt‐catalyzed coupling of alkynols with pyrrole‐ and indole‐substituted anilines allows an efficient access to fused title compounds.
ChemInform Abstract: An Efficient Solvent‐Free Synthesis of NH‐Pyrazoles from β‐Dimethylaminovinylketones and Hydrazine on Grinding.
Authors: Longhi Kelvis , Moreira Dayse N. , Marzari Mara R. B. , Floss Vagner M. , Bonacorso Helio G. , Zanatta Nilo , Martins Marcos A. P.
Published: September 2010

The preparation of NH‐pyrazoles according to A) is superior to the classical conditions in EtOH [cf.
ChemInform Abstract: Synthesis of 2H‐Indazoles by the [3 + 2] Cycloaddition of Arynes and Sydnones.
Authors: Wu Chunrui , Fang Yuesi , Larock Richard C. , Shi Feng
Published: September 2010

Compared with literature protocols, the described reaction offers very mild conditions, high yields, and excellent selectivities.
ChemInform Abstract: Four‐Component, One‐Pot Synthesis of Tetrasubstituted Imidazoles Using a Catalytic Amount of MCM‐41 or p‐TsOH.
Authors: Shoar Rahim Hekmat , Rahimzadeh Golnaz , Derikvand Fatemeh , Farzaneh Maryam
Published: September 2010

Mesoporous silica (MCM‐41) and TosOH are used as easy‐to‐handle solid acid catalysts under different optimized conditions.
ChemInform Abstract: Regioselective 1,3‐Dipolar Cycloaddition and 1,2‐Addition Between Benzaldoxime NH‐Nitrone and Perfluoro‐2‐methyl‐2‐pentene.
Authors: Lee Chan Woo , Park Joo Yuen , Kim Hyunuk , Chi Ki‐Whan
Published: September 2010

The stereochemistry of the 1,3‐dipolar cycloaddition and 1,2‐addition between benzaldoximes (I) and perfluoro‐2‐methyl‐2‐pentene (II) is studied.
ChemInform Abstract: Design, Synthesis, and in vitro Antitumor Evaluation of Novel Diaryl Ureas Derivatives.
Authors: Sun Min , Wu Xiaoqing , Chen Junqing , Cai Jin , Cao Meng , Ji Min
Published: September 2010

Two series of diaryl ureas are synthesized and their antitumor effect against human non‐small cell lung cancer cell line and breast cancer line is investigated.
ChemInform Abstract: Synthesis and Hypolipidemic Activity of Novel 2‐(4‐(2‐Substituted‐aminothiazole‐4‐yl)phenoxy) Acetic Acid Derivatives.
Authors: Mokale Santosh N. , Sanap Priyanka T. , Shinde Devanand B.
Published: September 2010

All synthesized compounds (I) are evaluated for their hypolipidemic activity by using high fat‐diet induced hyperlipidemia in Sprague‐Dawley rats.
ChemInform Abstract: Copper‐Catalyzed Activation of Disulfides as a Key Step in the Synthesis of Benzothiazole Moieties.
Authors: Hyvl Jakub , Srogl Jiri
Published: September 2010

The synthesis of benzothiazoles under mild conditions is described.
ChemInform Abstract: Synthesis of Azolylethyl Benzhydryl Ethers, Analogues of Diphenhydramine.
Authors: Burdeinyi M. L. , Popkov S. V. , Kharchevnikova M. V.
Published: September 2010

It is shown that the alkylation of 2‐(azol‐1‐yl)ethanols (III) with diarylmethyl halides (IV) in the presence of triethylamine is the optimum from some alternative methods for the synthesis of the title compounds (V).
ChemInform Abstract: Efficient One‐Pot Synthesis of Ethyl [2‐(2H‐Chromene‐3yl)‐4‐oxo‐1,3‐thiazolidin‐3‐yl]acetates.
Authors: Reddy S. Satyararayana , Krupadanam G. L. David
Published: September 2010

The reaction mechanism comprises a preliminary azomethine formation followed by nucleophilic attack of the mercapto group on the imine carbon, base‐catalyzed cyclization and subsequent dehydration.
ChemInform Abstract: Synthesis of Novel Polycyclic Indole‐Annulated Thiopyranocoumarin Derivatives via Domino Knoevenagel‐Hetero‐Diels—Alder Reaction in Aqueous Media.
Authors: Moghaddam Firouz Matloubi , Kiamehr Mostafa , Taheri Salman , Mirjafary Zohreh
Published: September 2010

A highly stereoselective method for the synthesis of novel heteropolycyclic compounds by a domino Knoevenagel—hetero‐Diels—Alder reaction is presented which can be performed in water.
ChemInform Abstract: Oxidation Aromatization of Hantzsch 1,4‐Dihydropyridines Catalyzed by Ferric Perchlorate in Ionic Liquids with Air.
Authors: Liu Dan , Gui Jianzhou , Wang Chan , Lu Feng , Yang Yulian , Sun Zhaolin
Published: September 2010

The catalytic system can be easily recovered and reused without loss of activity.
ChemInform Abstract: Synthesis of Polyhalogenated 4,4′‐Bipyridines via a Simple Dimerization Procedure.
Authors: Abboud Mohamed , Mamane Victor , Aubert Emmanuel , Lecomte Claude , Fort Yves
Published: September 2010

Treatment of halogenated pyridines with LDA results in convenient formation of 4,4′‐bipyridines.
ChemInform Abstract: Efficient and Simple Route for the Synthesis of N‐(2‐Pyridyl)‐4‐ethoxy‐5‐oxo‐2,5‐dihydro‐1H‐pyrrole‐2,3‐dicarboxylates.
Authors: Anary‐Abbasinejad Mohammad , Mirhossaini Marzieh , Parhami Azadeh , Pourhassan Ehsanorreza
Published: September 2010

A synthetic procedure for highly functionalized 3‐pyrrolin‐2‐ones is reported.
ChemInform Abstract: Tetrahydropyridine Derivatives with Inhibitory Activity on the Production of Proinflammatory Cytokines. Part 2.
Authors: Nakao Akira , Ohkawa Nobuyuki , Nagasaki Takayoshi , Kagari Takashi , Doi Hiromi , Shimozato Takaichi , Ushiyama Shigeru , Aoki Kazumasa
Published: September 2010

The synthesis and biological activity of N‐ and α‐position substituted tetrahydropyridine derivatives is presented.
ChemInform Abstract: One‐Pot Friedlaender Quinoline Synthesis: Scope and Limitations.
Authors: Li An‐Hu , et al. et al.
Published: September 2010

The approach involves reduction of o‐nitroaldehydes with iron, catalyzed by HCl.
ChemInform Abstract: Convenient and Efficient Preparation of Ethyl 6‐n‐Decyloxy‐7‐ethoxy‐4‐hydroxyquinoline‐3‐carboxylate.
Authors: Xu Maoyou , Zhang Jin , Wu Xue , Sun Juanjuan , Shi Zhiqiang
Published: September 2010

The target compound (IX) has the highest reactivity of decoquinate anticoccidial drugs.
ChemInform Abstract: Expeditious One‐Pot, Four‐Step Preparation of 2‐t‐Butoxycarbonyl‐6‐hydroxy‐1,2,3,4‐tetrahydroisoquinoline and an Improved Conversion to Its 6‐Cyano Derivative.
Authors: Gordon David W. , Bains Carol A.
Published: September 2010

Title compound (IV) is obtained in multigram quantities by a novel sequential one‐pot procedure comprising imination/Pictet—Spengler cyclization/demethylation/Boc‐protection.
ChemInform Abstract: Practical One‐Pot Syntheses of Regioisomeric Furan‐Fused Pyridinones (and Quinolinones) from Common Precursors.
Authors: Delaunay Thierry , Conreaux David , Bossharth Emmanuel , Desbordes Philippe , Monteiro Nuno , Balme Genevieve
Published: September 2010

The cyclization of substrates (I) follows remarkably divergent pathways when heated in acetic acid or triethylamine under microwave irradiation.
ChemInform Abstract: Diphenylammonium Triflate: A Novel and Efficient Catalyst for Synthesis of Spiro‐Heterocyclic Compounds.
Authors: Li Jianjun , Sun Jian , Su Weike
Published: September 2010

An efficient one‐pot procedure for the Biginelli reaction‐like pseudo‐four‐component reaction and a possible mechanism are reported.
ChemInform Abstract: Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones Using Ce(SO4)2—SiO2 as a Heterogeneous and Recyclable Catalyst.
Authors: Pei Wen , Wang Qin
Published: September 2010

Compared with the classical Biginelli reaction, the presented new method has the advantages of better product yields, short reaction time, easy separation and tolerance towards various functional groups.
ChemInform Abstract: Titanium(IV) Isopropoxide Mediated Synthesis of Pyrimidin‐4‐ones.
Authors: Ramanjulu Joshi M. , DeMartino Michael P. , Lan Yunfeng , Marquis Robert
Published: September 2010

The method tolerates a wide array of functionality and allows for rapid and efficient entry into tri‐ and tetrasubstituted pyrimidin‐4‐ones in a single step.
ChemInform Abstract: Highly Efficient Solvent‐Free Synthesis of Quinazolin‐4(3H)‐ones and 2,3‐Dihydroquinazolin‐4(1H)‐ones Using Tetrabutylammonium Bromide as Novel Ionic Liquid Catalyst.
Authors: Davoodnia A. , Allameh S. , Fakhari A. R. , Tavakoli‐Hoseini N.
Published: September 2010

A two‐step sequence involving cyclocondensation of 2‐aminobenzamide with aldehydes and subsequent oxidation by CuCl2 gives the required quinazolinones (IV).
ChemInform Abstract: Solvent‐Free Microwave Accelerated Synthesis of Heterocyclic Thiazolidin‐4‐ones as Antimicrobial and Antifungal Agents.
Authors: Sekhar Kondapalli Venkata Gowri C. , Rao Vajja Sambasiva , Reddy Aravalli Satish , Sunandini Ravada , Satuluri V. S. A. Kumar
Published: September 2010

A series of 8 title compounds of type (III) are prepared and tested for their antibacterial and antifungal activities.
ChemInform Abstract: Copper(II) Acetate Promoted Intramolecular Carboamination of Alkenes: An Efficient Synthesis of Pentacyclic Sultams.
Authors: Majumdar K. C. , Taher Abu , Nandi Raj Kumar
Published: September 2010

The oxidative cyclization of substrates (I) and (III) affords hitherto unreported title compounds of pharmaceutical interest.
ChemInform Abstract: High‐Yielding Microwave‐Assisted Synthesis of 2‐(Arylmethyl)amino‐4‐arylamino‐6‐alkyl‐1,3,5‐triazines.
Authors: Chen Huixiong , Dao Pascal , Laporte Alice , Garbay Christiane
Published: September 2010

A three‐step sequence is developed for the conversion of dicyandiamide and arylamines into the title compounds (VII).
ChemInform Abstract: Molecular Iodine Mediated Intramolecular Cyclization: An Efficient Method for the Synthesis of Benzoxepine Derivatives.
Authors: Majumdar K. C. , Sinha Biswajit , Ansary Inul , Chakravorty Santanu
Published: September 2010

The method offers a simple construction of target compounds (III) and (IV) as substructures of bioactive natural products.
ChemInform Abstract: A Formal [4 + 4] Complementary Ambiphile Pairing Reaction: A New Cyclization Pathway for ortho‐Quinone Methides.
Authors: Samarakoon Thiwanka B. , Hur Moon Y. , Kurtz Ryan D. , Hanson Paul R.
Published: September 2010

The feature of the title method is the complementary pairing of the two ambiphilic synthons, o‐fluorobenzenesulfonamide and ortho‐quinone methide, in a formal one‐pot [4 + 4] approach to afford the novel dibenzooxathiazocine‐2,2‐dioxide scaffold.
ChemInform Abstract: Impregnated Copper on Magnetite as Recyclable Catalyst for the Addition of Alkoxy Diboron Reagents to C—C Double Bonds.
Authors: Cano Rafael , Ramon Diego J. , Yus Miguel
Published: September 2010

The highly efficient catalyst allows simple formation of a wide range of organo‐boron compounds in high yields.
ChemInform Abstract: Nickel‐Catalyzed Asymmetric Addition of Alkyne C—H Bonds Across 1,3‐Dienes Using Taddol‐Based Chiral Phosphoramidite Ligands.
Authors: Shirakura Masamichi , Suginome Michinori
Published: September 2010

The use of the (Z)‐dienes and a slow addition of the alkyne substrate to a diene are crucial to obtain the products with high yields and selectivity and to prevent dimerization.
ChemInform Abstract: Preparation of Benzylphosphonates via a Palladium(0)‐Catalyzed Cross‐Coupling of H‐Phosphonate Diesters with Benzyl Halides. Synthetic and Mechanistic Studies.
Authors: Laven Gaston , Kalek Marcin , Jezowska Martina , Stawinski Jacek
Published: September 2010

A new and efficient method for the synthesis of benzylphosphonate and benzylphosphonothioate diesters (including nucleosides), involves a palladium(0)‐catalyzed cross‐coupling between benzyl halides and H‐phosphonate or H‐phosphonothioate diesters using Pd2(dba)3(CHCl3) as a palladium source and Xantphos as a supporting ligand.
ChemInform Abstract: Reactions of 4‐(Diethylamino)selenet‐2‐(2H)‐imine with Nucleophiles — Synthesis of 2‐Methylen‐3‐oxobutane Selenoamides.
Authors: Atanassov Plamen K. , Linden Anthony , Heimgartner Heinz
Published: September 2010

The title selenetimine (I) suffers an electrocyclic ring opening at elevated temperatures generating a ketenimine intermediate that can be easily trapped by N‐, O‐, and S‐nucleophiles.
ChemInform Abstract: Selective Approach Toward Multifunctionalized Lactams by Lewis Acid Promoted PhSe Group Transfer Radical Cyclization.
Authors: Yu Jin‐Di , Ding Wei , Lian Gao‐Yan , Song Ke‐Sheng , Zhang Dan‐Wei , Gao Xiang , Yang Dan
Published: September 2010

Irradiation of amido selenides in the presence of Yb(O‐Tf)3 allows an efficient, regiospecific, and stereoselective access to γ‐ and δ‐lactams.
ChemInform Abstract: A Short Synthesis of the Antileukemic Sesquiterpene (+)‐Caparratriene Employing Aqueous Wittig Chemistry.
Authors: Das Priyabrata , McNulty James
Published: September 2010

The three‐step synthesis of title compound (V) starts with the commercially available aldehyde precursor of alcohol (I) and involves a (4E) selective Wittig reaction of phosphonium bromide (III) with (R)‐citronellal as the key step.
ChemInform Abstract: NGF‐Potentiating Vibsane‐Type Diterpenoids from Viburnum sieboldii.
Authors: Kubo Miwa , Kishimoto Yoshiko , Harada Kenichi , Hioki Hideaki , Fukuyama Yoshiyasu
Published: September 2010

Isolation and structure determination of six new vibsane‐type diterpenoids, neovibsanin O (I), neovibsanin M (IIa), neovibsanin L (IIb), (8Z)‐neovibsanin M (III), 15‐O‐methylvibsanin H (IV), and 5‐epi‐15‐methylvibsanin H (V) are reported.
ChemInform Abstract: Cytotoxic N‐(Fluorenyl‐9‐methoxycarbonyl) (Fmoc)‐Dipeptides: Structure—Activity Relationships and Synergistic Studies.
Authors: Yen Chiao‐Ting , Wu Chin‐Chung , Lee Jin‐Ching , Chen Shu‐Li , Morris‐Natschke Susan L. , Hsieh Pei‐Wen , Wu Yang‐Chang
Published: September 2010

Thirty Fmoc‐based dipeptides are synthesized and their activity against six human cancer cell lines is evaluated.
ChemInform Abstract: Synthesis of Reversed C‐Nucleosides
Authors: Hashmi Imran Ali , Ali Firdous Imran , Fiest Holger , Peseke Klaus
Published: September 2010

via reactions of push‐pull activated aminomethyleneulose (I) with o‐phenylenediamine, cyanamide or 3‐oxoglutarate, respectively
ChemInform Abstract: A Naked Eye Detection of Fluoride with Urea Receptors which Have Both an Azo Group and a Nitrophenyl Group as a Signaling Group.
Authors: Dang Nhat Tuan , Park Jin Joo , Jang Soonmin , Kang Jongmin
Published: September 2010

Compounds (I) can serve as naked eye detector of fluoride anions.
ChemInform Abstract: Synthesis, Evaluation and Computational Studies on a Series of Acetophenone Based 1‐(Aryloxypropyl)‐4‐(chloroaryl) Piperazines as Potential Atypical Antipsychotics.
Authors: Bali Alka , Sharma Komal , Bhalla Abhishek , Bala Suman , Reddy Dinesh , Singh Anant , Kumar Anil
Published: September 2010

A series of substituted piperazines (I) is synthesized and evaluated for atypical antipsychotic activity.
ChemInform Abstract: Synthesis and Study of Antiproliferative Activity of Novel Thienopyrimidines on Glioblastoma Cells.
Authors: Pedeboscq Stephane , Gravier Denis , Casadebaig Francoise , Hou Genevieve , Gissot Arnaud , De Giorgi Francesca , Ichas Francois , Cambar Jean , Pometan Jean‐Paul
Published: September 2010

The thienopyrimidines synthesized, including five newly synthesized compounds, possess scaffolds which are very similar to those of known tyrosine kinase inhibitors approved for cancer treatment.
ChemInform Abstract: The Crystal Chemistry of Alkali‐, Alkaline‐Earth‐, Rare Earth‐Oxozirconates and Zirconium Oxides
Authors: Mueller‐Buschbaum Hanskarl
Published: September 2010

Review: 115 refs.
ChemInform Abstract: Measurements of Magnetic Materials
Authors: Fiorillo Fausto
Published: September 2010

Review: 82 refs.
ChemInform Abstract: Magnetic Phase Transitions in Nanoclusters and Nanostructures
Authors: Suzdalev I. P.
Published: September 2010

Review: 20 refs.
ChemInform Abstract: Surface‐Protected Etching of Mesoporous Oxide Shells for the Stabilization of Metal Nanocatalysts
Authors: Zhang Qiao , Lee Ilkeun , Ge Jianping , Zaera Francisco , Yin Yadong
Published: September 2010

Review: 170 refs.
ChemInform Abstract: Magnetism of Solids Resulting from Spin Polarization of P Orbitals
Authors: Volnianska O. , Boguslawski P.
Published: September 2010

Review: 127 refs.
ChemInform Abstract: Coordination Chemistry of Metal Enolato Complexes
Authors: Vicente Jose
Published: September 2010

Review: 231 refs.
ChemInform Abstract: General and Theoretical Aspects of the Metal Enolates
Authors: Domingo Luis R. , Andres Juan
Published: September 2010

Review: 233 refs.
ChemInform Abstract: Green Chemistry by Nano‐Catalysis
Authors: Polshettiwar Vivek , Varma Rajender S.
Published: September 2010

Review: 48 refs.
ChemInform Abstract: Polymer‐Supported Chiral Organocatalysts: Synthetic Strategies for the Road Towards Affordable Polymeric Immobilization
Authors: Kristensen Tor E. , Hansen Tore
Published: September 2010

Review: ca. 200 refs.
ChemInform Abstract: 4‐Isoxazolines: Scaffolds for Organic Synthesis
Authors: Pinho o Melo Teresa M. V. D.
Published: September 2010

Review: 81 refs.
ChemInform Abstract: Synthesis of 2′‐C‐Branched Nucleosides
Authors: Li Nan‐Sheng , Lu Jun , Piccirilli Joseph A.
Published: September 2010

Review: 150 refs.
ChemInform Abstract: Ligation—Desulfurization: A Powerful Combination in the Synthesis of Peptides and Glycopeptides
Authors: Rohde Heike , Seitz Oliver
Published: September 2010

Review: 60 refs.
ChemInform Abstract: Nucleotides and Nucleic Acids, Oligo‐ and Polynucleotides
Authors: Loakes David
Published: September 2010

Review: 894 refs.
ChemInform Abstract: Nucleotides and Nucleic Acids: Mononucleotides
Authors: Migaud M.
Published: September 2010

Review: 62 refs.
ChemInform Abstract: Total Synthesis of (+)‐Vinblastine: Control of the Stereochemistry at C‐18′
Authors: Yokoshima Satoshi , Tokuyama Hidetoshi , Fukuyama Tohru
Published: September 2010

Review: 43 refs.
ChemInform Abstract: Lewis Acid Organocatalysts
Authors: Sereda Oksana , Tabassum Sobia , Wilhelm Rene
Published: September 2010

Review: 242 refs.
ChemInform Abstract: Synthesis of Alkyl‐ and Cycloalkylamines by Hydroamination
Authors: Doye S.
Published: September 2010

Review: 299 refs.
ChemInform Abstract: From Helical Polyacetylene to Helical Graphite: Synthesis in the Chiral Nematic Liquid Crystal Field and Morphology‐Retaining Carbonization
Authors: Goh Munju , Matsushita Satoshi , Akagi Kazuo
Published: September 2010

Review: 70 refs.
ChemInform Abstract: Thermophysical Properties of Ionic Liquids
Authors: Rooney David , Jacquemin Johan , Gardas Ramesh
Published: September 2010

Review: 122 refs.
ChemInform Abstract: Polar Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)
Authors: Yonath A.
Published: September 2010

Review: 133 refs.
ChemInform Abstract: Improving Polymer Transistor Performance via Morphology Control
Authors: Tsao Hoi Nok , Muellen Klaus
Published: September 2010

Review: 80 refs.
ChemInform Abstract: Natural Product Mode of Action (MOA) Studies: A Link Between Natural and Synthetic Worlds
Authors: La Clair James J.
Published: September 2010

Review: ca. 250 refs.
ChemInform Abstract: Protein Micro‐Crystallography with a New Micro‐Beam Beamline
Authors: Yamamoto Masaki , Hirata Kunio , Hikima Takaaki , Kawano Yoshiaki , Ueno Go
Published: September 2010

Review: 16 ref.
Behavior of Elongated Liquid Jets in Viscous Liquid/Liquid Systems
Authors: Sellerberg M. , Walzel P.
Published: September 2010

Der Zerfall von viskosen Flüssigkeitsfäden in Flüssig/Flüssig‐Systemen ist eine geeignete Methode zur Herstellung von Emulsionen auch bei vergleichsweise hohen Durchsätzen. Die Stabilität von Fäden in Dehnströmungen kann dabei genutzt werden, um zunächst möglichst dünne Ligamente am Zerfallsort und damit feine Tropfen bei großen durchströmten Querschnitten zu erhalten. Es werden die Stabilitätsgrenzen und die auftretenden Zerfallsmechanismen untersucht.
Experimental study of droplet vaporization in a fluidized bed
Authors: Leclère Karine , Briens Cédric L. , Bergougnou Maurice A. , Bayle JÉRôme , Gauthier Thierry , Guigon Pierre
Published: September 2010

The injection of liquid in a hot fluidized bed is used in many industrial processes. The larger droplets are likely to engulf particles and create agglomerates that should be avoided when a fast vaporization is expected. A new model is proposed to estimate the chances of agglomeration based on a critical bed temperature below which agglomerates form. This critical temperature for safe operating conditions is based on heat transfer between the particles and the liquid and takes the porosity of the solid into account. The model could be applied to pure and multi‐component mixtures and has been validated experimentally.
Sequential experimental design for estimation and analysis of thermal parameters in a fixed bed
Authors: de Oliveira Samuel Conceição , Dechechi Eduardo CÉSar , Filho Rubens Maciel , Freire José Teixeira , Bueno
Published: September 2010

The analysis of the effective radial thermal conductivity and the film heat transfer coefficient were carried out in a fixed bed. The temperature profiles were described by two‐dimensional pseudo‐homogeneous model. The thermal parameters were estimated using a sequential experimental design technique. The minimum volume criterion was used to design the next point for temperature measurement in the bed. The utilization of T = T0 (constant) as the boundary condition at the bed inlet resulted in an axial variation of thermal parameters, which was the factor responsible for the inadequacy of the model in fitting experimental data of different bed heights simultaneously. Using T = T(r) as the boundary condition makes the thermal parameters independent of the axial position and the model statiscally adequate to describe the axial and radial temperature profiles throughout the bed.
Oxidative dehydrogenation of propane to propene, 2: Simulation of a commercial inert membrane reactor immersed in a fluidized bed
Authors: Ramos Raquel , Pina M. Pilar , Menéndez Miguel , Santamaría Jesús , Patience Gregory S.
Published: September 2010

A novel reactor concept is proposed for partial oxidation reactions that combines membrane and fluid bed reactor technology in a single vessel. Air fluidizes the shell side in which both membrane tubes — charged with catalyst — and cooling coils are immersed. Oxygen transport through the membrane wall is controlled by pressure drop. Model simulations, based on the kinetics for the oxidative dehydrogenation of propane to propene, show improved performance compared to conventional fixed bed technology. The controlled oxygen addition along the axis improves propene selectivity and broadens the operating range with respect to hydrocarbon and oxygen feed rates.
The process dynamics of filler retention in paper using a CPAM/bentonite retention aid system
Authors: Cho Byoung‐Uk , Garnier Gil , Paradis Jean , Perrier Michel
Published: September 2010

In an effort to develop robust control strategies for the wet‐end of papermaking, an experimental program was carried out to model the dynamic behaviour of the filler retention in paper using a Fourdrinier pilot paper machine and a cationic poly(acrylamide)/bentonite retention aid system. A dynamic simulation model of the pilot paper machine was developed from first‐principles. To describe the wet‐end chemistry effect, the first‐pass retention was included in the model as a new independent variable. The important factors affecting the dynamics of the wet‐end are first‐pass retention and the parameters related to the white water circulation.
N‐arylhydroxamic acids as mineral collectors for ore‐beneficiation
Authors: Natarajan Ramanathan , Nirdosh Inderjit
Published: September 2010

Several arylhydroxamic acids were synthesized, characterized and tested as collectors in the flotation of a Cu‐Zn sulphide ore. Arylhydroxamic acids floated copper in preference to iron and zinc minerals. Substitution in the N‐phenyl ring increased the efficiency of the collector. However, increase in alkyl‐chain beyond C6 in the acyl group decreased the flotation efficiency of the collector. N‐butanoylphenylhydroxylamine was found to give the best result and floated about 93 wt% of Cu in about 32 wt% of the feed taken and the collector usage was only about 70 g per tonne of the ore. Pyrite flotation was minimum at pH 11.
Air stripping effect in a chemostat
Authors: Lin Yen‐Han , Hill Gordon A.
Published: September 2010

The effect of air stripping on a chemostat is Investigated. An operating diagram is constructed to illustrate the relationship between the volatile substrate and the dilution rate subjected to different amounts of air stripping. Air stripping provides another degree of freedom to operate a chemostat in addition to manipulating feed concentration and dilution rate. Thus, a high dose of feed substrate can be tolerated while still maintaining the process in a stable‐operating mode. A stable operation of a chemostat is guaranteed when a proper combination of feed substrate concentration, initial start‐up conditions and aeration rates is implemented.
Effect of Electronic Structures of Enantiomers of Ruthenium(II) Polypyridyl Complexes on DNA Binding Behaviors
Authors: Luo Haimei , Xiao Jie , Chen Jincan , Xu Hong , Lu Jun , Liu Zhigang , Chen Siping , Tong Mingliang , Zheng Kangcheng , Ji Liangnian
Published: September 2010

A pair of Ru(II) complex enantiomers, Δ‐ and Λ‐[Ru(bpy)2(p‐mpip)]2+ {bpy=2,2′‐bipyridine, p‐mpip=2‐(4‐methylphenyl)imidazo[4,5‐f]‐1,10‐phenanthroline} have been synthesized and structurally characterized. Both experimental results from crystallography, NMR, electrochemistry and theoretical calculations applying the density functional theory (DFT) method based on their crystal structures show that small difference in geometric structure existed can cause a considerable difference in electronic structure between enantiomers. In addition, the binding of the two enantiomers to calf thymus DNA (CT DNA) has been investigated with UV spectroscopy titration and viscosity measurements. It is very rare that the Λ enantiomer binds to DNA more strongly than the Δ enantiomer, which can be reasonably explained by their different electronic structures for the first time, suggesting that the dominant factor governing the stereoselectivity of DNA binding of Ru(II) complex may be the different electronic structures of its enantiomers.
Structures, IR, NMR Spectra and Thermodynamics Properties of Halogenated Compounds X‐1‐ZB11H10 (ZO, S, Se; XF, Cl, Br): A DFT Study
Authors: Li Ping
Published: September 2010

The halogenated compounds of twelve‐vertex closo‐1‐ZB11H11(Z=O, S, Se; X=F, Cl, Br) have unusual stability. The structures of halogenated isomers obtained by DFT method indicate that the halogen atoms are more likely to attack the meta vertexes. The chemical thermodynamic properties show that the halogenations are spontaneous and exothermic. The result that both the optimized and experimental cages of closo‐thiaborane have not changed after chlorination indicates that the substitution of a chlorine atom for a hydrogen atom of closo‐thiaborane happens at outer of the cage. The calculated electronic structures show that the three‐dimensioned aromaticity of cage would like positive chlorine atoms to attack. The halogenations by elemental halogen in the presence of metal halides were proved to belong to the electrophilic substitutions and the mechanism was discussed in details. The suggested transition state interpreted the experiments. The thermal rearrangement which was supposed early according to experiments was verified by the thermodynamic properties of chlorination theoretically. The IR and 11B/1H NMR isotropic chemical shifts were calculated and compared with the experimental data to reconfirm the structures of chlorinated closo‐thiaborane. Furthermore, the predictions on the halogenated closo‐oxaborane and closo‐selenaborane are significant for the syntheses.
A Theoretical Study on the Vibrational Spectra and Thermodynamic Properties for the Derivatives of 2,5‐Dipicryl‐1,3,4‐oxadiazole with N3, ONO2, and NNO2 Groups
Authors: Wang Guixiang , Gong Xuedong , Liu Yan , Du Hongchen , Xu Xiaojuan , Xiao Heming
Published: September 2010

The derivatives of 2,5‐dipicryl‐1,3,4‐oxadiazole (DPO) were optimized to obtain their molecular geometries and electronic structures at the DFT‐B3LYP/6‐31G* level. Their IR spectra were obtained and assigned by vibrational analysis. Compared with the experimental results, all the calculated IR data were found to be reliable. Based on the frequencies scaled by 0.96 and the principle of statistic thermodynamics, the thermodynamic properties were evaluated, which are respectively linearly related with the number of azido, nitrate and nitramine groups as well as the temperature, obviously showing good group additivity.
Density Functional Study of Two Seven‐Membered Unconventional Fullerenes C58F17CF3 and C58F18
Authors: Tang Chunmei , Zhu Weihua , Deng Kaiming
Published: September 2010

The density functional method is used to study the structure, electronic properties, static linear polarizabilities, and optical absorption spectra of two seven‐membered unconventional fullerene derivatives C58F17CF3 and C58F18. It is calculated that three sites chosen to locate the CF3 are isoenergetic. The energy gaps of C58F18 and C58F17CF3 are much larger than that of C58, indicating the fluorination and trifluoromethylation of C58 can remarkably enhance the kinetic stability. The density of states explore that the influence of CF3 to the energy levels is mainly distributed in the energy range from −10 to −2 eV. However, when the CF3 substitutes for F in C58F18, the bond lengths, energy gaps, static linear polarizabilities, and optical absorption spectra all show small variety.
DFT Study for the Reduction of N2O(1Σ+) with CO(1Σ+) Catalyzed by Cr+
Authors: Liu Fengxia , Zhang Jianhui , Hu Minzhe , Wang Yongcheng , Leng Yanli
Published: September 2010

The mechanism of the reaction N2O(1Σ+)+CO(1Σ+)→N2(1Σ)+CO2(1Σ) catalyzed by Cr+ has been investigated on sextet and quartet potential energy surfaces. The reactions are studied by using the UB3LYP density functional method and the standard 6‐311+G(2d) basis sets. The geometries for reactants, the transition states and the products are completely optimized. The result shows that the reaction proceeds in a two‐step manner, each mechanism are insertion‐elimination and rearrangement mechanism. The involved crossing between the two potential energy surfaces have been discussed by means of the intrinsic reaction coordinate (IRC) approach, and the crossing points (CPs) are located. The minimum energy crossing point (MECP) that we obtained by the mathematical algorithm proposed by Harvey et al. has been also employed. Then the action of frontier molecular orbitals in MECPs were illuminated briefly. Finally, O‐atom affinities (OA) testified that the argumentation is thermodynamically allowed.
Syntheses, Crystal Structures and Luminescent Properties of a Dimeric Complex [(bzdmpzm)Cu(µ‐I)]2 and a Polymeric Complex [(bzdmpzm)Cu(µ‐NCS)]n (bzdmpzm=Bis(4‐benzyl‐3,5‐dimethyl‐1H‐pyrazol‐1‐yl)methane)
Authors: Wang Huihui , Li Hongxi , Ren Zhigang , Chen Yang , Lang Jianping
Published: September 2010

Reactions of CuX (X=I, NCS) with bis(4‐benzyl‐3,5‐dimethyl‐1H‐pyrazol‐1‐yl)methane (bzdmpzm) in MeCN resulted in the formation of one dimer [(bzdmpzm)Cu(µ‐I)]2 (1) and one 1D polymer [(bzdmpzm)Cu(µ‐NCS)]n (2) in high yields. 1 and 2 were characterized by elemental analysis, IR, 1H NMR spectra, powder X‐ray diffraction and single‐crystal X‐ray diffraction. 1 consists of two scorpion‐like [(bzdmpzm)Cu]+ fragments bridged by two iodides, forming a dimeric structure. 2 contains a unique 1D scolopendra‐like chain of [(bzdmpzm)Cu]+ fragments linked by pairs of thiocyanates. The luminescence properties of 1 and 2 were also investigated.
Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A
Authors: Zhang Wenjuan , Xu Jing , Liu Fang , Li Chufang , Jie Yanling , Chen Shaopeng , Li Zhiyuan , Liu Jinsong , Chen Ling , Zhou Guochun
Published: September 2010

Inhibitors bearing the imidazole, adamantane and related structures were synthesized and tested against WT, S31N and S31N‐L26I mutant M2 channels. Although amantadine (1) only inhibited WT M2 channel, compound 6 containing the imidazole and adamantane groups showed good inhibitory activity to WT and mutant M2 channels. The stereochemistry and basic pKa of α‐amine are important for the activity of inhibitors and our data showed that derivatives of natural histidine are more active for M2 channels than those of unnatural histidine. The significance of our present results is that we have established a prospective strategy of drug discovery of WT and mutant M2 channels against influenza A.
Equilibrium Studies on Reactive Extraction of α‐Cyclohexyl‐mandelic Enantiomers Using Hydrophilic β‐Cyclodextrin Derivatives Extractants
Authors: Tang Kewen , Miao Jiabing , Liu Yongbing , Zhou Tao , Song Litao
Published: September 2010

β‐Cyclodextrin (β‐CD) is negligibly soluble in organic liquids and can be modified to achieve a higher solubility in water. In this paper, racemic α‐cyclohexyl‐mandelic acid (α‐CHMA) was separated by chiral reactive extraction with aqueous β‐cyclodextrin derivatives. Hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD), hydroxyethyl‐β‐cyclodextrin (HE‐β‐CD), and methyl‐β‐cyclodextrin (Me‐β‐CD) were selected as chiral selectors for reactive extraction of α‐CHMA enantiomers from organic phase to aqueous phase. Factors affecting the extraction efficiency were investigated, including the types of organic solvents and β‐CD derivatives, the concentrations of the chiral selector and α‐CHMA enantiomers, pH and temperature. The experimental results demonstrate that HP‐β‐CD, HE‐β‐CD, and Me‐β‐CD have stronger recognition abilities for S‐α‐CHMA than for R‐α‐CHMA. Among the three derivatives, HP‐β‐CD shows the strongest separation factor for α‐CHMA enantiomers. A high enantioseparation efficiency with a maximum separation factor (α) of 2.02 is observed at pH 2.5 and 5°C.
A Novel Sample Pretreatment Method for the Analysis of Polybrominated Diphenyl Ethers in Polymers of Waste Electrical and Electronic Equipment (WEEE)
Authors: Huang Fan , Meng Xiangzhou , Chen Ling , Xiang Nan , Liu Ying , Li Guangming
Published: September 2010

A fast sample pretreatment method was developed to determine polybrominated diphenyl ethers (PBDEs) in polymers from waste electrical and electronic equipment (WEEE). Polymers were firstly prepared into "polymer film" to facilitate a complete Soxtec extraction. Then, three extraction parameters (including hot plate temperature, boiling time, and rinsing time) were optimized based on the recovery of target in reference polymer samples. The proposed method was successfully applied to the analysis of PBDEs in standard plastic materials from WEEE and the extraction yields of PBDEs ranged from 78.9% to 91.3%. The detection limits of PBDEs were 0.05–0.10 µg/g, indicating this method can be used as a quality assurance and quality control procedure of PBDEs in the production of electrical and electronic equipment.