bluuebunny/crossref_metadata_2025 huggingface dataset:
Waste management plan with reduce, reuse, recycle (3r) method
Authors: Mahartin Tika Luthfi
Published: October 2023

Garbage is a problem that is quite concerning in Indonesia. Most of the waste generated comes from household waste and plastic waste. The increase in waste production is influenced by population growth, the speed of development and the socio-economic level of the community which grows every year. The increase in the amount of waste is not proportional to the expansion of the landfill area. Disposal/TPA conditions in several areas are already overloaded, one of which is in Batang Regency. The Randukuning TPA in Batang Regency is already overloaded with the amount of waste produced reaching 500 tons per day with a landfill area of 2.5 hectares. Waste management is a structured, comprehensive and sustainable activity that includes waste reduction and handling. One effort that can be done to reduce waste is to sort waste from its source and apply 3R (Reduce, Reuse, Recycle).
Analisis indeks kesadaran masyarakat terhadap obat dan makanan yang aman dan bermutu tahun 2022
Authors: Sihaloho Rona Monika
Published: October 2023

Tingkat kesadaran masyarakat  terhadap kesehatan merupakan pengukuran yang dilakukan untuk melihat seberapa besar pengetahuan masyarakat tentang tingkat kesehatan pada kehidupan mereka sehari-hari. Keberhasilan program pengawasan Obat dan Makanan yang dilakukan Badan POM diukur dari dampaknya terhadap masyarakat. Diperkirakan masih banyak produk Obat dan Makanan mengandung bahan berbahaya. Tujuan menyediakan data indeks kesadaran masyarakat terhadap Obat dan Makanan yang Aman dan Bermutu yang dilakukan Badan POM level Nasional tahun 2022. Pengukuran menggunakan metode kuantitatif cross sectional dan non intervensi melalui survei di 34 Provinsi. Metode penetapan sampel yaitu Stratified Two Stage Sampling yang mempresentasikan Nasional dan Provinsi, memilih blok sensus secara Probability Proportional to Size (PPS) dengan jumlah perkiraan rumah tangga setiap provinsi dan strata urban. Pengembangan metode dan desain sampel dilakukan oleh team BPOM bersama Direktorat Pengembangan Metodologi Sensus dan Survei, BPS. Pengumpulan data menggunakan kuisioner terstruktur melalui wawancara tatap muka metode Computer Assisted Personal Interviewing (CAPI) secara offline dan online. Pengukuran indeks kesadaran masyarakat dibentuk melalui tiga aspek yaitu Pengetahuan, Sikap dan Perilaku. Variabel pertanyaan disusun menggunakan pendekatan KLIK yaitu membeli produk dengan kemasan yang baik, membaca label, memilih produk yang memiliki izin edan dan produk yang tidak kedaluwarsa.  Jawaban pertanyaan menggunakan skala likert dikonversi menjadi 0-100 dengan kategori: Tidak baik/Tidak Puas (≤45,00); Kurang Baik/Kurang Puas (45,01-60,00); Cukup Baik/Cukup Puas (60.01-75,00); Baik/Puas (75,01-90,00); Sangat Baik/Sangat Puas (≥ 90,01). Analisis data dilakukan melalui perhitungan Indeks, Analisis Deskriptif, Analisis Lanjutan (Anova dan Korelasi), Analisis SEM dan Analisis Kualitatif Indeks Kesadaran terhadap Obat dan Makanan yang Aman dan Bermutu tahun 2022 tingkat nasional sebesar 81,56 (Kategori Baik), target nilai 80 (101,95%). Hasil pengukuran Indeks kesadaran dibentuk dari 3 (tiga) indikator, indikator sikap masyarakat yaitu 84,59, pengetahuan masyarkat 83,47 dan indikator kesadaran masyarakat 76,63. Berdasarkan hasil pengukuran indeks kesadaran masyarakat tahun 2022, direkomendasikan: 1) Meningkatkan sinergi dengan lintas sektor terkait, 2) Meningkatkan strategi komunikasi, sosialisasi dan penyuluhan KIE melalui elektronik dan non elektronik,  3) Menyusun materi informasi dan edukasi produk Obat dan Makanan, 4) Menggencarkan promosi tagline cek KLIK dan BPOM Mobile, 5) Melakukan monev terhadap program pemberdayaan masyarakat dan tindak lanjut dari rekomendasi tahun sebelumnya.
Paparan timbal dalam urin remaja pada kejadian gangguan sistem saraf dan keseimbangan di kecamatan Curug
Authors: Levanta Dhia Syarifa , Hananingtyas Izza
Published: October 2023

In the production process, there are several industries that use Pb in their production process, one of which is in the battery smelting process. The explanation that the source of Pb pollution in Kec. Curug comes from battery recycling industry activities. One of the groups in society that is at risk of being affected is early adolescence which at that age is a period of rapid growth and development, both physically, psychologically and intellectually. Pb accumulation in body tissues, especially in the nerves will cause disturbances in the nervous system both structurally and functionally. It is known that it affects different parts of the brain, one of which is the cerebellum which has the function of coordinating adjustments quickly and automatically by maintaining body balance. The population of this study were 92 early adolescents in two high schools in Permata, Kec. Waterfall with a sample of 52 people. Examination of balance disorders is done with the Romberg test. This study used a cross-sectional study design with this type of observational research. In conclution, (92.3%) early teens urine contain Lead (Pb) are still below the specified Treshold Value (<50 µg/L). The emergence of complaints of the central nervous system and the balance disorder in early teens can be caused by other factors.
Efektivitas mandatory spending fungsi kesehatan dan dampaknya terhadap derajat kesehatan masyarakat di Provinsi Papua
Authors: Ahyuni Siti , Sutjipto Hady
Published: October 2023

Efektivitas mandatory spending fungsi kesehatan merupakan salah satu bentuk instrumen dari kebijakan fiskal yang bertujuan untuk mewujudkan pembangunan derajat kesehatan di Provinsi Papua. Penelitian ini bertujuan untuk menganalisis perkembangan serta pengaruh efektivitas alokasi mandatory spending fungsi kesehatan terhadap pembangunan derajat kesehatan masyarakat di 28 Kabupaten/Kota Provinsi Papua periode tahun 2017-2019. Analisis mandatory spending fungsi kesehatan Kabupaten/Kota Provinsi Papua mencakup belanja kesehatan, dana otonomi khusus, dan dana alokasi umum. Metode yang digunakan penelitian ini adalah pendekatan kuantitatif yang menggunakan analisis regresi data panel dengan model Fixed Effect Model (FEM). Hasil penelitian ini menunjukkan bahwa secara simultan, variabel mandatory spending berpengaruh signifikan terhadap derajat kesehatan masyarakat di Kabupaten/Kota Provinsi Papua, sedangkan secara parsial variabel belanja kesehatan dan dana alokasi umum memiliki pengaruh signifikan terhadap indikator derajat kesehatan, berbeda dengan variabel dana otonomi khusus yang tidak memiliki pengaruh signifikan terhadap derajat kesehatan masyarakat di Kabupaten/Kota Provinsi Papua.
Praktik kerja industri bidang management human resources department Hilton Garden Inn Bali Ngurah Rai airport
Authors: Prameswari Made Bintang Nadiva , Witarsana I Gusti Agung Gede
Published: October 2023

Setiap organisasi tentunya harus memiliki tenaga kerja yang akan menangani atau mengurus jalannya organisasi agar tujuan organisasi dapat sukses tercapai. Tanpa adanya peran manusia didalamnya maka jalannya perusahaan tidak bisa terlaksana. Setiap organisasi tentunya harus memiliki tenaga kerja yang akan menangani atau mengurus jalannya organisasi agar tujuan organisasi dapat sukses tercapai. Tanpa adanya peran manusia didalamnya maka jalannya perusahaan tidak bisa terlaksana. Pada penelitian ini, manajemen dari Hotel Hilton Garden Inn Ngurah Rai Airport menjadwalkan 4 hari kerja dan 3 hari libur dalam seminggu di masa pandemic ini, dalam 1 hari penulis bekerja dalam waktu 9 jam dengan rincian 8 jam kerja dan 1 jam istirahat. Hotel Hilton Garden Inn Ngurah Rai Airport mewajibkan seluruh trainee untuk mengikuti Orientation Day yang diadakan selama 1 hari pada awal memulai pelaksanaan praktek kerja industri, yang bertujuan untuk memberikan pengenalan mengenai hotel seperti membahas sejarah, fasilitas, peraturan, dan pengetahuan mengenai safety & security. Menjalani program ini, penulis menyadari bahwa penulis mendapatkan kesempatan untuk bertemu dan bersosialisasi dengan para pekerja, diberikan kepercayaan untuk menyelesaikan tugas-tugas administrasi di departemen Human Resources, para senior dengan ramah berbagi dan memberikan wawasan dan pengetahuannya kepada penulis, memberikan kesempatan kepada penulis untuk mengajukan ide, pendapat, serta berpikir kreatif.
CARACTERÍSTICAS E INDICADORES QUE DEBE CUMPLIR UN PROGRAMADOR EN EL CAMPO LABORAL
Authors: Domínguez Ibáñez Daniel , Tovar López Jhoselin Adilene , Aguilar Pérez Efraín
Published: October 2023

En el presente documento se realiza un análisis en distintas empresas para ver qué características e indicadores debe tener un programador para ser apto para el puesto. El resultado fue que existen varias características e indicadores que coinciden en distintas empresas. El objetivo de esta investigación se centra en ver las características como herramientas y conocimientos, e indicadores conforme a tiempos que debe de cumplir un programador en el campo laboral. Así, los estudiantes, egresados, profesores e incluso interesados en el tema, podrán tener un cuadro más amplio de lo que las empresas desarrolladoras de software demandan para sus empleados, e incluso puedan prepararse en base a estas características e indicadores y así estar más aptos para trabajar o enseñar (en el caso de profesores) para tales empresas. Y las empresas desarrolladoras de software puedan ser más competitivas manejando dichas características e indicadores.
ANÁLISIS COSTO-BENEFICIO DE TARJETAS GRÁFICAS DEDICADAS AL GAMING
Authors: Lizárraga Osuna Diego Francisco , Velarde Hernández Luis Antonio
Published: October 2023

En esta investigación se realizó una comparativa de las distintas tarjetas gráficas de los últimos 2 años, donde se encontró que en el año 2020 a 2022 han llegado al mercado nuevas tarjetas gráficas enfocadas a los videojuegos con un mejor rendimiento y mejor costo. Se muestran los resultados de un análisis costo-beneficio mostrando las características de cada una al igual que su precio, y se realizó la comparación con el objetivo de mostrar las mejores tarjetas gráficas con un mejor costo y rendimiento.
PENGARUH KREATIVITAS, INOVASI DAN TRANSFORMASI DIGITAL TERHADAP KEWIRAUSAHAAN UMKM DI PANGKALPINANG
Authors: Indria  , Astuti Nelly , Maharani Yunita
Published: October 2023

This research was entitled: “Pengaruh Kreativitas, Inovasi Dan Transformasi Digital Terhadap Kewirausahaan UMKM Di Pangkalpinang.”.

The background of this research is based on existing phenomena showing that the competition among MSME is increasing digitally during the pandemic. The purpose of this study was to determine and examine the effect of creativity, innovation and digital transformation towards entrepreneurship, both simultaneously and partially.

The method of research is a descriptive quantitative study with a sample size of 100 respondents. This study has three independent variables; creativity, innovation and digital transformation. The dependent variable was labeled as an entrepreneurship.

Testing instruments are using validity and reliability tests. The data analysis method used in this study is Multiple Linear Regression Analysis using the F-test along with Simple Linear Regression with T-test. Also the researcher use an analysis of the Coefficient of Determination (R2) in order to provide empirically  the ability to explaining the dependent by two independence variables simultaneously.

The results of the research on the independent variable creativity (X1) obtained t-count 2.932 > t-table 1.660, innovation variable (X2) with t-count 6,022 > t-table 1.660 and digital transformation variable (X3) with t-count 7,022 > t-table 1.660 Therefore, a creativity has a partial effect towards entrepreneurship, and an innovation has a partial effect towards entrepreneurship. Also, the study stated if digital transformation has a partial a partial effect towards enterpreneurship.

The results of the F-test show that F-count 50.485 > F-table 2.70. This means that the independent variables (creativity, innovation and digital transformation) simultaneously has an affect towards the dependent variable (entreprenurship). The test results of the Coefficient of Determination (R2) show Adjusted R-Square 0.600 or in other word, that entrepreneurship variables can be explained by variables creativity, innovation and digital transformation) by 60%. While the remaining 0,400 or 40% can be explained by other variables outside the research variables.
ANALISIS STUDI KELAYAKAN BISNIS PADA PETERNAKAN BURUNG PUYUH DI KOTA PANGKALPINANG
Authors: Sapira Meisye , Astuti Nelly , Maharani Yunita
Published: October 2023

This thesis research entitled in Indonesian: “Analisis Studi Kelayakan Bisnis Peternakan Burung Telur Puyuh di Pangkalpinang" regarding feasibility study of Mrs. Maymuna's Quail Farm business is a business established with capital own capital, which is Rp 24,276,000,- investment capital and Rp 78,400.00,- operational capital in 1 period. The sales products produced by quail breeding are quail eggs and quail droppings. This study aims to determine the Market and Marketing Aspects, Aspects of Technical and technology, and financial aspects in Maymuna's mother quail farm which is located at JL. Parit Lalang, Rangkui Village, Pangkalpinang City. This research was carried out from February to June 2021 with data collection techniques in the form of observations and interviews. The method used is Aspect Market and Marketing, Technical and Technological Aspects, and Financial Aspect.

Market and Marketing analysis shows that the prospect of Mrs. Maymuna's farm is quite good, this can be seen from the increase in the number of requests every year. Quality production at an affordable price, and a fairly good strategy related to the marketing mix.Technical and Technological analysis shows that the condition of the location and production equipment is clean and quality maintained, and meets production capacity. Based on the calculations of the five types of investment assessments, it is obtained that the financial aspects are reviewed from four types of investment assessments, namely Payback Period (PP),which is 10 months, the Net Present Value (NPV) is 124% -, the value of the Average Rate of Return (ARR) is Rp.1.070.442.412%, greater than 100%. Profitability Index (PI) That is Rp. 8.12801392.
PENGARUH PERSEPSI KEMUDAHAN PENGGUNAAN (EASE OF USE), KENYAMANAN (CONVENIENCE), KEPERCAYAAN (TRUST) DAN KETERSEDIAAN FITUR (FEATURE AVAILABILITY) TERHADAP MINAT NASABAH DALAM MENGGUNAKAN INTERNET BANKING KLIKBCA (STUDI KASUS PADA NASABAH PT BANK CENTRAL A
Authors: Harianto Herry , Tri Setyo Mulyani Hendarti , Oktalina Gayatria
Published: October 2023

This study aims to analyze and obtain evidence on the influence of perceptions of ease of use, convenience, trust and feature availability of intention to use internet banking KlikBCA. The results of this study are expected to contribute to the Bank in particular BCA in order to provide a service that is faster and easier for its customers. The object of this study is the BCA’s customers who use internet banking. Data used in this study are primary data, and data searching used questionnaires directly. The data used is primary data formed questionnaires that apply to BCA’s costumers who use KlikBCA in Pangkalpinang amount is 97 respondents and using method non probability sampling : purposive sampling. The results showed that perceptions ease of use, convenience, trust and feature availability has positive and significance impact on interest in using internet banking.
ANALISIS PENERAPAN PSAK NOMOR 46 PAJAK PENGHASILAN ATAS LAPORAN KEUANGAN TAHUN 2021 DI CV. NUSANTARA MAKMUR SEJAHTERA
Authors: Leslie Jennifer , Tri Setyo Mulyani Hendarti , Novika
Published: October 2023

Companies often face obstacles in the process of recognizing all the consequences of tax calculations on financial statements. This causes differences between commercially recognized financial statements and fiscal financial statements. CV. Nusantara Makmur Sejahtera is a company that sells various types of facial, hair and body beauty products. The purpose of this study was to evaluate whether CV. Nusantara Makmur Sejahtera has implemented PSAK No. 46 in the company's financial statements.

         The research uses qualitative methods with descriptive analysis, namely looking at the 2021 financial reports. The data used in this study is primary data, and the type of data used is documentary data.

         The research finding is that there is a difference between the financial statements that are recognized fiscally and commercially. This causes a negative fiscal correction to the depreciation account. Based on the calculation, the total negative fiscal correction is Rp. 58,830,650.

        So that the application of PSAK No. 46 in the financial statements of CV. Nusantara Makmur Sejahtera is not perfect yet. To overcome this problem, the company must follow the tax regulations that have been set by PSAK No. 46
PERSUASIVE ASSISTANCE AND PROBLEM-SOLVING FOR THE ESTABLISHMENT OF VILLAGE-OWNED ENTERPRISES
Authors: Dr Suyanto
Published: October 2023

Background. Programs from local governments to develop and prosper village communities through Village-Owned Enterprises (hereinafter better known as BUMDes) are in line with Law No. 6/2014 article 1 paragraph 6. However, the establishment of BUMDes is still unknown to the village community and many problems make village communities unable to take advantage of BUMDes. The purpose of this activity was to 1) increase knowledge of Tanjung village communities about BUMDes, 2) determine village potential, establishment, and management of BUMDes.
Implementation Method. This community service activity was in collaboration with the Lamongan Government Sector and Indonesian Notary Association of East Java Regional Management through "Notary Masuk Desa" program. This activity was carried out in Tanjung Village, Lamongan Regency. This activity starts from providing seminars to village leaders and the Tanjung Village community on how to establish BUMDes until the establishment of BUMDes. Assistance related to all problems while managing BUMDes and providing legal or economic solutions.
Findings. BUMDes and Tanjung Village business units that were formed include village electricity businesses, electricity payment services, and agricultural production facilities, providing credit/loans that are easily accessible to the community. During the running period of 6 months, the business unit was running well and problems began when village capital was still used by the credit business unit and the legality aspects of the village business unit that had been formed.
Conclusion. BUMDes requires transparent, active, and integrity management to be following the purpose of its formation to improve the economy of the village and community.
LEGAL PROTECTION FOR KENJERAN BEACH FISHERMEN IN THE ERA OF INDUSTRIAL REVOLUTION 4.0
Authors: Irianto Bambang S.
Published: October 2023

Background. The reduction in the number of fishermen over the last 3-5 years has affected the fish catch in Surabaya, for the last 5 years it has continuously decreased. The uncertainty of the income obtained by fishermen from fishing and the limited fishing gear and the current increase in fuel prices add to the heavy burden on fishermen. In addition, the influence of the west wind season. The purpose of this research was to create a problem-solving strategy and develop community skills on the Kenjeran coastline both in the management of fish, and catch of the sea around the Kenjeran coastline.
Research Method. This research was a type of Community Based Research. The research was conducted from March to June 2021, location was in Nambangan- Cumpat Fishermen Village, Kedung Cowek, Bulak, Surabaya City. The population in this study were members of the Fishermen's Group from each village, totaling 115 people. The research analysis approach is through Islamic eco-theology.
Findings. Fishing activity is the main livelihood of coastal communities so when they cannot go to sea it means they cannot fulfill their daily needs. The results of this activity found several descriptions, situations of social structure, conditions, and problems faced by fishing communities, including population density, sanitation, slum environments, natural weather which is also an obstacle for fishermen to catch fish, narrow employment opportunities, and other social inequality.
Conclusion. Efforts to understand Islamic eco-theology in the Kenjeran coastal fishing community are one of the means to conserve the coastal environment.
IMPLEMENTATION OF SAFE DROWNING SANCTIONS FOREIGN FISHING VESSELS IN FISHERIES CRIMES
Authors: Irianto Bambang
Published: October 2023

Background. Fishing activities carried out by a certain country or foreign fishing vessels in waters that are not in its jurisdiction without permission from the country that has jurisdiction. The purpose was to determine the sanctions against perpetrators of fisheries crimes in Indonesia and the implementation of sanctions for the sinking of foreign fishing vessels that commit fishing crimes without permission in Indonesia.

Research Method. This research was type of normative legal research, doctrinal research because this research is conducted or aimed only at written regulations and other legal materials. Normative legal research is also referred to as literature review because this research is mostly done on secondary data in the library and document studies.

Findings. The implementation of the sanction of sinking foreign fishing vessels against perpetrators of fisheries crimes is carried out through court decisions or due to caught red-handed foreign fishing vessels confiscated based on Court decisions can be sunk by the Prosecutor as the executor or executor of the judge's decision. In the case of being caught red-handed, it must be based on sufficient preliminary evidence or preliminary evidence to suspect the existence of fisheries crime by foreign fishing vessels.

Conclusion. Sanctions against perpetrators of fisheries crime are heavy sanctions, because they are cumulative, namely imprisonment and fines imposed at the same time against the perpetrators of criminal acts. In addition to criminal sanctions, perpetrators can also be subject to administrative sanctions in the form of warnings, license suspension and up to license revocation.
Spiller aktivismen en rolle i de danske udenrigspolitiske strategier?
Authors: Larsen Henrik
Published: October 2023

Lanceringen af den udenrigs- og sikkerhedspolitiske strategi i maj 2023 har givet anledning til en fornyet debat om dansk udenrigspolitiske aktivisme. En fællesnævner i debatten, som deles med den akademiske litteratur, er, at dansk udenrigspolitisk aktivisme ses som noget bestemt og identificerbart. I denne artikel ønsker jeg med en anderledes tilgang at se på, hvordan ordet forstås i det danske politiske miljø på baggrund af en performativitetsforståelse. Artiklen undersøger, hvordan ”aktivisme” og beslægtede ord er blevet brugt i de fire danske udenrigspolitiske strategier. Det konkluderes, at ord, der kan associeres til aktivisme, optræder i alle udenrigspolitiske strategier, og at brugen af disse ord varierer med den politiske kontekst. Det er ikke så meget ”aktivisme”, der driver dansk udenrigspolitik, som det er de politiske prioriteringer på et givet tidspunkt, der former brugen af ”aktivisme”. På denne baggrund rejses spørgsmålet om, hvorvidt den særlige forskningsmæssige opmærksomhed på dansk aktivisme kan begrundes.
Socio-pedagogical design in the training of students of pedagogical universities in the context of the formation of a coherent environment of the future
Authors: Glebova Lyubov' Nikolaevna
Published: October 2023

The author considers the problem of using socio-pedagogical design as a condition for training students of pedagogical universities in the context of the formation of a coherent environment of the future, reveals the features of such socio-pedagogical design, its structure, presents a model for implementing a system of training students of pedagogical universities of socio-pedagogical design as a guarantor of readiness for future professional activity and conditions for maintaining a harmonious educational environment as a means of formation of personality. The need to develop a model for the use of socio-pedagogical design in the training of students of pedagogical universities in the context of the formation of a coherent environment of the future is caused by a number of reasons: the uneven development of the environment with the priority requirement of the organization of effective education and personal development. Instability, inconsistency of environments leads to a negative impact on the personality both in psychological terms (discomfort, contradictory, ambivalent experiences) and in the pedagogical aspect (lack of a stable idea of values, problems with choosing and building a priority of values, difficulties in forming a stable worldview). A coherent educational environment, or, in other words, a balanced, harmonized one, is able to maximize the capabilities to solve the problems of the educational process, maintain concentration, adequate interactions of all environments with each other. This is possible with the extraction of its potential by specialists who possess advising competencies.
An acoustic-based method for locating maternity colonies of rare woodland bats
Authors: O’Malley Kieran D. , Schofield Henry , Wright Patrick G.R. , Hargreaves Daniel , Kitching Tom , Bollo Palacios Marina , Mathews Fiona
Published: October 2023

Locating colonies of rare bats can be a time consuming process, as it is often difficult to know where to focus survey effort. However, identifying peaks of bat activity via acoustic monitoring may provide insights into whether a colony is locally present, and help screen out sites with low potential. Using a triage approach, we developed a survey methodology for locating colonies of the woodland-specialist barbastelle bat (Barbastella barbastellus). We investigated whether woodland occupancy by a colony could be predicted by acoustic data, and assessed the influence of survey effort (number of acoustic detectors deployed) on detectability. The methodology was then trialled in citizen science surveys of 77 woodlands, with follow-up radio-tracking surveys by specialists being used to confirm presence or absence. Using Receiver Operating Characteristic (ROC) curve analysis, we found that a threshold of four barbastelle passes recorded by at least one detector within one hour of sunset optimised the balance between the true- and false-positive rates. Subsequently, we found that a minimum survey effort of one detector per 6.25 hectares of woodland was needed to ensure a colony would be detected using this threshold, based on a survey sensitivity of 90%. Radio-tracking surveys in a subset of the woodlands, identified as having a high probability of being occupied by a colony based on acoustic monitoring, confirmed the presence of five previously unknown barbastelle maternity colonies. These results demonstrate that a triage system, in which high probability woodland sites are identified based on acoustic survey data, can be used to prioritise sites for future specialist surveys and conservation action.
High LYRM4-AS1 predicts poor prognosis in patients with glioma and correlates with immune infiltration
Authors: Wang Hai yue , Xie Ying , Du Hongzhen , Luo Bin , Li Zengning
Published: October 2023

Background

Many researches proved that non-coding RNAs are important in glioma development. We screened the differentially expressed genes through The Cancer Genome Atlas (TCGA) database and identified the molecule LYRM4-AS1 associated with prognosis. As a lncRNA, the expression level and role of LYRM4-AS1 in glioma are inconclusive. Therefore, we attempted to assess the clinical significance, expression and related mechanisms of LYRM4-AS1 in glioma by employing cell experiments and an integrative in silico methodology.

Methods

RNA-seq data were obtained from UCSC XENA and TCGA datasets. The Gene Expression Omnibus (GEO) database was used to download glioma-related expression profile data. The LYRM4-AS1 expression level was evaluated. Survival curves were constructed by the Kaplan–Meier method. Cox regression analysis was used to analyze independent variables. Patients were divided into high and low expression group base on the median LYRM4-AS1 expression value in glioma tissues. The DESeq2 R package was used to identify differentially expressed genes (DEGs) between two different expression LYRM4-AS1 groups. Gene set enrichment analysis (GSEA) was conducted. Next, the single-sample Gene Set Enrichment Analysis (ssGSEA) was done to quantify the immune infiltration of immune cells in glioma tissues. Gene expression profiles for glioma tumor tissues were used to quantify the relative enrichment score for each immune cell. Spearman correlation analysis was used to analyze the correlation between LYRM4-AS1 and biomarkers of immune cells as well as immune checkpoints in glioma. Finally, assays for cell apoptosis, cell viability and wound healing were conducted to evaluate the function on U87 MG and U251 cells after knocking down LYRM4-AS1.

Results

We found that LYRM4-AS1 was upregulated and related to the grade and malignancy of glioma. Survival analyses showed that high expression LYRM4-AS1 patients had poor clinical outcomes (P < 0.01). Cox regression analyses demonstrated that LYRM4-AS1 was an independent risk factor for overall survival (OS) in glioma (HR: 274 1.836; CI [1.278–2.639]; P = 0.001). Enrichment and immune infiltration analysis showed interferon signaling and cytokine-cytokine receptor interaction enriched in the LYRM4-AS1 high-expression phenotype, and LYRM4-AS1 showed significantly positively related to immune infiltration as well as immune checkpoints (P < 0.01). The knockdown of LYRM4-AS1 in U87 MG and U251 cells can inhibit migration and proliferation of cells (P < 0.05).

Conclusions

These findings indicated that the increased LYRM4-AS1 may be useful for the diagnosis and prognosis of glioma and might participate in the immune infiltration.
Identification and validation of hub genes involved in foam cell formation and atherosclerosis development via bioinformatics
Authors: Teng Da , Chen Hongping , Jia Wenjuan , Ren Qingmiao , Ding Xiaoning , Zhang Lihui , Gong Lei , Wang Hua , Zhong Lin , Yang Jun
Published: October 2023

Background

Foam cells play crucial roles in all phases of atherosclerosis. However, until now, the specific mechanisms by which these foam cells contribute to atherosclerosis remain unclear. We aimed to identify novel foam cell biomarkers and interventional targets for atherosclerosis, characterizing their potential mechanisms in the progression of atherosclerosis.

Methods

Microarray data of atherosclerosis and foam cells were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expression genes (DEGs) were screened using the “LIMMA” package in R software. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Ontology (GO) annotation were both carried out. Hub genes were found in Cytoscape after a protein-protein interaction (PPI) enrichment analysis was carried out. Validation of important genes in the GSE41571 dataset, cellular assays, and tissue samples.

Results

A total of 407 DEGs in atherosclerosis and 219 DEGs in foam cells were identified, and the DEGs in atherosclerosis were mainly involved in cell proliferation and differentiation. CSF1R and PLAUR were identified as common hub genes and validated in GSE41571. In addition, we also found that the expression of CSF1R and PLAUR gradually increased with the accumulation of lipids and disease progression in cell and tissue experiments.

Conclusion

CSF1R and PLAUR are key hub genes of foam cells and may play an important role in the biological process of atherosclerosis. These results advance our understanding of the mechanism behind atherosclerosis and potential therapeutic targets for future development.
Effect of body mass index on soft tissues in adolescents with skeletal class I and normal facial height
Authors: Karsli Nurver , Tuhan Kutlu Esra
Published: October 2023

Background

The evaluation of soft tissues in patients undergoing orthodontic treatment plays a critical role in diagnosis and treatment planning. This study aims to evaluate the effect of body mass index (BMI) on facial soft tissues in skeletal Class I patients with normal vertical growth.

Methods

The study included 72 patients with a normal vertical growth pattern (SN-GoGn 26–38°) and skeletal Class I (ANB 2‒4°) malocclusion. According to their BMI (kg/m2) values, the patients were divided into three groups of 24 individuals each: underweight (>5th percentile) (13 females, 11 males; mean age, 11.58 ± 1.95 years), normal weight (5‒85th percentile) (12 females, 12 males; mean age, 11.54 ± 1.95 years), overweight (85‒95th percentile) (12 females, 12 males; mean age, 11.62 ± 2.01 years). Soft tissue thickness and height measurements were made on lateral cephalometric radiographs.

Results

In all soft tissue thickness measurements, except for the nasion, the overweight weight group had higher values. In comparing the underweight and normal weight groups, statistically significant differences were found in the thickness measurements at the nasion and gnathion (p < 0.05). The differences in thickness measurements at the glabella, labiale superius, stomion, labiale inferius, pogonion, gnathion, and menton are statistically significant between the underweight and overweight groups (p < 0.005). Comparing the normal and overweight groups revealed statistically significant differences the thickness measurements at the glabella, labiale superius, stomion, pogonion and menton (p < 0.05).
Propuesta metodológica para el análisis de la comunicación promocional en festivales musicales
Authors: Rivera Magos Sergio , Negrete Huelga Karla Belem , Fernández Barros María de la Luz
Published: October 2023

El artículo busca presentar un diseño metodológico para el estudio de festivales musicales que permita analizar los planos en línea y offline , así como su etapa previa y desarrollo. Así, pretende superar las limitantes espacio-temporales de estudios previos, analizando el espacio físico y el digital. Desde una perspectiva comunicacional-publicitaria, la investigación aborda el caso mexicano partiendo de la premisa de que los festivales musicales establecen alianzas estratégicas con marcas patrocinadoras que, más allá de los criterios comerciales que las unen crean conjuntamente, desde distintos canales, una experiencia en los asistentes que genera una huella física, simbólica y digital. El objetivo de la investigación es entonces conocer cómo los festivales y las marcas concretan sus interacciones a través de los planos en los que se desarrolla el festival, considerando que la generación de la experiencia comienza antes de la culminación del evento. Asimismo, el texto entrega una síntesis de los principales hallazgos de cada etapa de una investigación realizada, bajo esta propuesta metodológica, en festivales mexicanos entre 2018 y 2020. El trabajo concluye destacando la importancia de las plataformas digitales para la estrategia de comunicación de los festivales, tanto en la etapa prepandemia como en la de pandemia, y la centralidad del espacio físico como escenario del discurso publicitario que expresa la relación entre los festivales musicales y sus patrocinadores.
Tipos de metadados utilizados na representação de informação sobre coleções de arte
Authors: Tarré Alonso Beatriz , Díaz-Redondo Carlos , Monteiro de Barros Camila
Published: October 2023

O avanço das tecnologias tem permitido a representação ilimitada em redes de dados interconectadas em contextos díspares, mas enfrenta o problema da ausência de interpretações nas descrições. O presente estudo tem abordagem quali-quantitativa, caráter descritivo, desenho experimental e corte transversal. Seu objetivo é analisar os tipos de metadados utilizados por diferentes museus na representação de informações sobre coleções de obras de arte. Entre seus procedimentos metodológicos estão a análise documental e comparativa. Analisa o estado da representação de obras pictóricas em 34 museus e galerias da Europa, a América do Norte e o Caribe. Foram inspecionados 38 metadados descritivos, por meio dos websites da amostra. Os resultados mostram a predominância de metadados com tipologia descritiva e estrutural, com pouca profundidade no que se refere à análise interpretativa das obras. O comportamento da descrição não tem o nível de profundidade necessário. Portanto, a aplicação de métodos semânticos e interdisciplinares é de extrema importância para alcançar um senso de informação mais preciso e logicamente estruturado, revelar novos conhecimentos e oferecer dados interoperáveis ​​que possam ser recuperados de forma eficaz
Regressão linear-circular para modelagem de dados meteorológicos
Authors: Da Silva Clodoaldo Teodosio Santana , Brighenti Carla Regina Guimarães
Published: October 2023

Modelos de regressão são utilizados para analisar o comportamento de uma variável em relação às outras. Quando os dados são provenientes da reta real podem ser usados, por exemplo, modelos de regressão linear. No entanto, quando os dados são resultantes de medidas angulares, que podem surgir a partir de observações relacionadas à direção de voos de pássaros, dados meteorológicos, meses do ano, assim, a melhor alternativa é utilizar os modelos de regressão para dados circulares. Neste trabalho, os são dados provenientes do INMET e referentes à estação meteorológica situada na cidade de São João del Rei-MG, no período de 01/01/2020 a 31/12/2021. O modelo linear-circular foi selecionado, sendo a variável resposta a radiação solar, a variável explicativa, circular, os meses do ano. Para o ajuste foi utilizado o software R, o qual foi significativo e a covariável umidade foi inserida no modelo. Os parâmetros foram significativos ao nível de significância de 1%. Para validar o modelo foi utilizada a análise dos resíduos, e indicou ajuste satisfatório. Através da estatística circular foi possível verificar os períodos de picos de radiação, e em que meses do ano ocorreram altas radiações.
Análise Comparativa e Aplicabilidade das Normas e Legislações Correlatas à Lei 12.305/10 – Política Nacional de Resíduos Sólidos (PNRS)
Authors: De Moraes Clauciana Schmidt Bueno , Maia Juliana Victoria Ferreira , Pinto Willian Leandro Henrique , Julião Danielle Paes , Bonaretto Cinthia Mara Vital , Martires Giulia Malaguti Braghini Marcolini , Camolezi Juliane Zaccarias
Published: October 2023

A geração de resíduos pelos seres humanos sempre ocorreu, mas intensificou-se após a Revolução Industrial, com o aumento da produção e com o crescimento acelerado das cidades. Assim, o incremento da geração desses resíduos, associado à sua disposição inadequada impulsionou a criação de leis nacionais e internacionais para o gerenciamento de resíduos. Em 2010, foi instituída a Política Nacional de Resíduos Sólidos (PNRS), que dispõe sobre princípios, objetivos, instrumentos e diretrizes para a gestão integrada e gerenciamento de resíduos sólidos no Brasil. Diversas outras normas e resoluções também foram criadas para assegurar o correto gerenciamento de resíduos sólidos, mas a quantidade e a diversidade de instrumentos normativos dificultam sua aplicação de forma efetiva e prática pelos órgãos governamentais, setor privado e municípios. Nesse contexto, o objetivo deste trabalho foi analisar as diferenças e similaridades da Política Nacional de Resíduos Sólidos (PNRS) com as normas e legislações do Estado de São Paulo, por meio de uma matriz de correlação e uma análise de contexto, de aplicabilidade e de dificuldades de aplicação, com o intuito de facilitar o gerenciamento e a gestão municipal no tema Resíduos Sólidos. Com esta pesquisa, observou-se que existe uma grande quantidade de obrigações legais a serem seguidas, mas que, devido ao desconhecimento de sua existência e à falta de recursos, muitas vezes não são integralmente aplicadas. Isso fundamenta a necessidade deste estudo, que tem potencial para contribuir para a melhor aplicabilidade das legislações e normas nos órgãos públicos e privados.
Incubadora de empreendimentos para egressos do sistema penal, recomendações para uma reintegração social
Authors: Honorato Wilson Magdo Sena , Alves Tatyane Cristina , De Sousa André Cláudio , Diniz Nathália Beraldo Ribeiro Drumond , Chaves Fernando de Castro , De Souza Neto Bezamat
Published: October 2023

A Incubadora de Empreendimentos para Egressos tem como missão fomentar ações inovadoras em desenvolvimento humano de reeducandos, egressos do sistema penitenciário, jovens em conflito com a lei e todo e qualquer cidadão, criando oportunidades através da qualificação e formação empreendedora, despertando o empoderamento e a reconstrução de identidades. O projeto propõe criar parcerias entre a universidade, incubadoras e associações de assistência a condenados visando à integração social de homens e mulheres, que passaram pelo sistema prisional, através da prática do empreendedorismo. A Incubadora para egressos tem como objetivo aprimorar a capacidade gerencial de empreendedores dos setores de comércio, serviços e indústria, contribuindo, através do fortalecimento de seus próprios negócios, para sua reintegração social. Dessa forma, criar oportunidades para outros egressos, multiplicando o número de beneficiados e revertendo, assim, a realidade de discriminação e consequente desemprego por eles enfrentado.
Verrucous Haemangioma with Histoid Leprosy: A Case Report
Authors: Mohan Atul , Ansari Mohammad Hamza , Yadav Vandana , Agarwal Aanchal , Singh Satyendra Kumar
Published: October 2023

Verrucous Haemangioma (VH) is a rare, congenital vascular malformation of cutaneous and subcutaneous tissue. It usually presents as macular lesion at birth which progresses with age, and may become bluish papules, nodules, and warty plaques. Linear presentation of this disease is even rarer. Here the present case report presents a case of a 30-year-old male patient with multiple raised erythematous hyperkeratotic papules and plaques over right forearm since birth which was arranged in a linear pattern.The patient also had asymptomatic papules on right thigh and lower back region, associated with sensory loss and peripheral nerve thickening. Dermoscopy of forearm showed reddish-blue lacunae, alveolar pattern, and whitish veils. Colour Doppler showed intradermal dilated venous channels with thrombosis which was suggestive of haemangioma. Histopathological examination confirmed the diagnosis of linear VH on forearm and slit skin Ziehl-Neelsen staining was suggestive of histoid leprosy. Linear VH is a rare congenital venous malformation, progresses proportionately with age. Dermoscopy can help in early diagnosis of vascular lesions. Complete surgical excision is the treatment of choice.
Role of Sperm DNA Fragmentation Index in Semen Analysis in Couples with Unexplained Recurrent Pregnancy Loss: A Case-control Study
Authors: Hooda Ruchi , Devi G Geeta
Published: October 2023

Introduction: Infertility has been on the rise, and male factor infertility has gained attention in cases of Recurrent Pregnancy Loss (RPL). Traditional Semen Analysis (SA) has been the main diagnostic tool, but with advancements in Assisted Reproductive Technology (ART) and the need for more accurate testing, there is a demand for improved diagnostic tests that correlate with reproductive outcomes. Sperm DNA Fragmentation Index (DFI) is a parameter used to assess the degree of sperm DNA damage and is considered crucial in evaluating semen quality. Aim: To investigate the role of Sperm DNA Fragmentation (SDF) in patients presenting with RPL compared to a control group. Materials and Methods: The study was conducted over a two-year period from January 2021 to December 2022 at the Centre for Infertility Management and Assisted Reproduction (CIMAR), Edappal Hospital, Edappal, Kerala, India. The control group (Group A; n=31) comprised males aged between 21-45 years whose partners had no history of recurrent abortions. The case group (Group B; n=31) included males with two or more pregnancy losses. Sperm DFI analysis and routine SA were performed in both groups to assess semen parameters such as volume, concentration, progressive and non progessive motility, morphology, and DFI. Statistical analysis was performed using the Independent student t-test. Results: In the present study the mean age of males in Group A was 37.03±5.416 years and in Group B was 35.44±4.552 years. There were no significant differences observed between the case and control groups in terms of sperm volume (p=0.301), concentration (p=0.155), progressive motility (p=0.207), non progessive motility (p=0.178), and morphology (p=0.362). However, a statistically significant difference was found between the RPL and control groups for DFI (p<0.001), with a mean value of ±8.15 in the control group and ±19.35 in the case group. Conclusion: The present study demonstrates that SDF is an important factor in RPL, with couples experiencing RPL showing a higher incidence of SDF. Therefore, incorporating SDF analysis alongside routine SA should be considered, particularly in patients with a history of RPL.
Primary Aldosteronism: A Series of 11 Cases
Authors: Dhar Abhranil , Das Tapas Chandra , Sahana Pranab Kumar , Singhania Pankaj , Chowdhury Subhankar
Published: October 2023

Primary Aldosteronism (PA) should be suspected in patients with resistant hypertension, early-onset hypertension, hypertension with hypokalaemia, and metabolic alkalosis. The diagnosis is often missed due to a lack of awareness and cumbersome investigations. Eleven cases of PA who attended the Endocrinology Outpatient Department (OPD) and were also admitted to the hospital over the last three years (January 2020 to January 2023) were studied, and data were collected and analysed. All 11 patients had hypertension, and five out of 11 had resistant hypertension and 36.36% (four patients) had a family history of hypertension. In this cohort, nine out of 11 patients presented with hypokalaemia (81.81%), and five of them had hypokalaemic paralysis at presentation. In 54.54% of patients, plasma aldosterone was in the range of 20-40 ng/dL, with a mean plasma Aldosterone conc. of 31.7 ng/dL. Plasma Renin Activity (PRA) was suppressed in all eight patients. In nine out of 11 patients, PAC/PRA was >20. A left-sided adrenal adenoma was observed in 54.54% of cases. Six patients (54.54%) received surgical management (laparoscopic adrenalectomy), and the remaining five patients were doing well with medical management (antihypertensives and spironolactone). This case series illustrates the need for screening of PA in patients with resistant hypertension, specifically those with hypokalaemia. Elevated PAC is diagnostic, especially in the context of suppressed PRA. Computed Tomography (CT) is the modality of choice for localising the adenoma in most cases. Clinicians can make decisions regarding the choice of treatment based on these two investigations.