bluuebunny/crossref_metadata_2025 huggingface dataset:
Checklist of fossil liverworts suitable for calibrating phylogenetic reconstructions
Authors: FELDBERG KATHRIN , GRADSTEIN S. ROBBERT , GRÖHN CARSTEN , HEINRICHS† JOCHEN , VON KONRAT MATT , MAMONTOV YURIY S. , RENNER MATT A.M. , ROTH MADITA , SCHÄFER-VERWIMP ALFONS , SUKKHARAK PHIANGPHAK , SCHMIDT ALEXANDER R.
Published: June 2021

The number of available liverwort fossils substantially increased within the past decade, which is mainly due to new findings from Cretaceous and Cenozoic amber deposits. Many of them, however, are fragmentary and not predestined for consideration in evolutionary analyses. Here, we list those liverwort fossils that we suggest as suitable for calibrating phylogenetic reconstructions, along with brief descriptions, justification of their use, and age information. Our recommendations are based on thorough microscopic investigation of available fossils from worldwide amber collections including recent findings. We recommend that the following 42 fossil taxa can be used as confident minimum age constraints in phylogenetic reconstructions: Acrolejeunea ucrainica (35 Ma), Anastrophyllum rovnoi (35 Ma), Bazzania polyodus (34 Ma), Blepharolejeunea obovata (15 Ma), the genus Bryopteris with B. bispinosa and B. succinea (15 Ma), Calypogeia stenzeliana (34 Ma), Cephaloziella nadezhdae (35 Ma), the genus Ceratolejeunea with C. antiqua, C. palaeomexicana, and C. sublaetefusca (15 Ma), Cheilolejeunea latiloba (34 Ma), Cheirorhiza brittae (158 Ma), Cololejeunea sp. (15 Ma), Cyclolejeunea archaica (15 Ma), Dibrachiella grollei (15 Ma), Diettertia montanensis (112 Ma), Drepanolejeunea eogena (15 Ma), the genus Frullania with F. baerlocheri, F. cretacea, and F. partita (99 Ma), Frullania subgen. Frullania with F. casparyi (34 Ma) and F. riclefgrollei (35 Ma), F. subgen. Trachycolea with F. rovnoi (35 Ma) and F. schumannii (34 Ma), Gackstroemia cretacea (99 Ma), Geocalyx heinrichsii (34 Ma), the genus Lejeunea with L. hamatiloba, L. miocenica, L. resinata, and L. urbanioides (15 Ma), Lopholejeunea subnigricans (15 Ma), Marchantites cyathodoides (228 Ma), Marchesinia brachiata (15 Ma), Metzgeriothallus sharonae (383 Ma), Microlejeunea nyiahae (52 Ma), Neurolejeunea macrostipula (15 Ma), Nipponolejeunea europaea (34 Ma), Notoscyphus balticus (34 Ma), Odontoschisma (sect. Iwatsukia) dimorpha (34 Ma), Plagiochila groehnii (34 Ma), Porella subgrandiloba (34 Ma), Protolophozia kutscheri (34 Ma), Radula (subgen. Odontoradula) cretacea (99 Ma), R. (subgen. Amentuloradula) heinrichsii (99 Ma), Scapania hoffeinsiana (34 Ma), Solenostoma berendtii (34 Ma), Spruceanthus polonicus (34 Ma), Stictolejeunea squamata (15 Ma), Tetralophozia groehnii (34 Ma), Thysananthus auriculatus (15 Ma), Thysananthus contortus (34 Ma). Furthermore, we transfer Lophozia kutscheri to Protolophozia, Archilejeunea grollei to Dibrachiella, Frullania ucrainica to Acrolejeunea, and Mastigolejeunea extincta to Spruceanthus, based on new fossil evidence and morphological revisions.
A new critically endangered slippery frog (Amphibia, Conrauidae, Conraua) from the Atewa Range, central Ghana
Authors: NEIRA-SALAMEA KARLA , OFORI-BOATENG CALEB , KOUAMÉ N’GORAN G. , BLACKBURN DAVID C. , SEGNIAGBETO GABRIEL H. , HILLERS ANNIKA , BAREJ MICHAEL F. , LEACHÉ ADAM D. , RÖDEL MARK-OLIVER
Published: June 2021

Forty-nine years after the last description of a slippery frog, we describe a seventh species of the genus Conraua. The new Conraua is endemic to the Atewa Range Forest Reserve, central Ghana, and is described based on genetic, bioacoustics, and morphological evidence. Recent molecular phylogenetic and species delimitation analyses support this population as distinct from nominotypical C. derooi in eastern Ghana and adjacent Togo. The new species is sister to C. derooi, from which it differs ~4% in the DNA sequence for mitochondrial ribosomal 16S. Genetic divergences in 16S to other species of Conraua range from 4–12%. The new species is distinguished morphologically from its congeners, including C. derooi, by the combination of the following characters: medium body size, robust limbs, lateral dermal fringing along edges of fingers, cream ventral color with brown mottling, the presence of a lateral line system, indistinct tympanum, the presence of inner, outer, and middle palmar tubercles, and two subarticular tubercles on fingers III and IV. We compare the advertisement calls of the new species with the calls from C. derooi and find that they differ by duration, frequency modulation, and dominant frequency. We discuss two potential drivers of speciation between C. derooi and the new species, including river barriers and fragmentation of previously more widespread forests in West Africa. Finally, we highlight the importance of the Atewa Range Forest Reserve as a critical conservation area within the Upper Guinean biodiversity hotspot.
Using fitness trackers to increase physical activity in a US Army health initiative
Authors: Brown Jill A , Whittaker Kerry S , Hawkins Stacy Ann , Jackson Santo Theresa , Teyhen Deydre S
Published: June 2021

Objective:

Fitness trackers are appealing in public health intervention programmes aimed at promoting physical activity, but it is unclear whether tracker use leads to health behaviour change in soldiers. This programme evaluation investigated the effects of fitness tracker usage on goal-setting, self-monitoring and physical activity behaviours in soldiers participating in a 6-month pilot health promotion programme focused on improving sleep, activity and nutrition behaviours.

Design:

Participants in this programme ( n = 4,418) were assigned to a health education, an education plus fitness tracker or a comparison (i.e. no intervention) condition. Data were collected at baseline, 3 and 6 months.

Setting:

Soldiers in five brigades participated in one of the three conditions, with health education integrated into daily operations.

Method:

Participants in the health education and education plus fitness tracker conditions were exposed to materials distributed via health educators and through leader interaction. Participants in the education plus fitness tracker condition were also assigned a fitness tracker for use.

Results:

Self-monitoring increased in all conditions over time; however, there was a significant interaction of group by time, such that individuals in the fitness tracker condition reported significantly greater increases in self-monitoring over time, compared with the other groups. Conversely, self-reported physical activity decreased in all conditions over time, with no significant interaction, indicating no effect of group membership.

Conclusion:

Although fitness trackers are popular in the health and fitness industry, they may have limited utility as a public health intervention aimed at increasing physical activity in soldiers participating in this programme.
Measuring recovery in Arabic countries: Translation of the self-efficacy for personal recovery scale
Authors: Ibrahim Nashwa , Newby Christopher , Thomas Neil , Slade Mike
Published: June 2021

Self-efficacy – positive beliefs about one’s own competencies and mastery – is associated with better recovery outcomes for people using mental health services.

Aim:

To translate the Self-Efficacy for Personal Recovery Scale (SEPRS) into Arabic and evaluate the psychometric properties of the Arabic version.

Methods:

An established translation methodology was employed, involving back-translation, comparison, forward-translation, comparison, and piloting. The pre-final version of the Arabic translated scale was tested for clarity with young people with a primary diagnosis of mental health problem. The final Arabic version and standardized measures of hope and loneliness were administered to 119 young people in two rounds.

Results:

Internal consistency was adequate (Cronbach’s alpha = 0.87 in round 1, 0.91 in round 2). Consistent with the English version, a one-factor solution best fitted the data. The correlation between SEPRS and hope was R = 0.60 (round 1) and R = 0.61 (round 2), indicating convergent validity. The correlation between SEPRS and loneliness was R = −0.52 (round 1) and R = −0.60 (round 2). Correlation between test and retest was R = −0.998 indicated adequate test-retest reliability. Minimal floor and ceiling effects were detected.

Conclusion:

The use of the Arabic SEPRS with Arabic-speaking samples is supported. Further research to investigate divergent validity is warranted.
A qualitative examination of the mental health impact of Covid-19 in marginalized communities in Guatemala: The Covid Care Calls survey
Authors: Alonzo Dana , Popescu Marciana
Published: June 2021

Background:

The mental health impact of Covid-19 from the perspective of individuals experiencing psychological distress during lockdown period in marginalized, high-risk communities remains underinvestigated.

Aims:

This study aims to identify key factors related to psychological distress resulting from the Covid-19 pandemic across highly vulnerable districts in Guatemala.

Methods:

The Covid Care Calls (CCC) survey was administered to households in 11 districts in Guatemala to gather information about medical, mental health, and psychosocial status during the lockdown period; provide referral for care; and disseminate information on evidence-based protective measures to stem the spread of the virus. The 330 individuals participated the survey. Conventional content analysis was used to analyze survey data.

Results:

Most commonly reported mental health issues since the start of the pandemic were anxiety (46%), stress (36%), and exacerbation of pre-Covid-19 mental health conditions (19%). Depression and burnout were equally reported by 12% of participants. Only 2% reported issues with safety in the home. Concerns about catching the virus and economic worries were the most commonly reported sources of psychological distress.

Conclusion:

Results of this study indicate a high prevalence of anxiety, stress, and increased prior mental health symptoms resulting from the onset of the Covid-19 pandemic in low-income, high-risk communities across Guatemala. Efforts focused on enhancing coping strategies as well as psychoeducation to address stigma and increase help-seeking for depression are particularly important.
Application of computed tomography data–based modelling technique for polymeric low density foams, Part A: Model development
Authors: Hössinger-Kalteis Anna , Reiter Martin , Jerabek Michael , Major Zoltán
Published: June 2021

In this research study, a methodology is introduced for generating finite element simulation models for low density closed cell foams based on computed tomography (CT) measurement results. Creating this kind of simulation models can be very expensive with regard to modelling and computational effort. Hence, a combined modelling technique based on CT data and Voronoi diagrams is developed that minimizes this effort, but nevertheless, generates simulation models with a realistic microstructure. In this article, the generation of simulation models using this modelling method and the necessary adaptation of the models concerning microstructural features to consider, for example, anisotropic properties of the foam, are described. Furthermore, simulations are performed to investigate the mechanical performance of the foam models and to compare the results with several analytical models and experimental data. Finally, conclusions regarding the applicability and possible further extensions of the model are provided.
To confront sexual violence, we must train non-forensic experts to perform medico-legal evaluations
Authors: Mishori Ranit , Naimer Karen , McHale Thomas , Johnson Katy , Fateen Dahlia , Gillette-Pierce Zahada
Published: June 2021

Sexual violence is a global crisis. Forensic evaluations are critical for obtaining evidence and increasing the likelihood of accessing justice, as many cases fail due to lack of evidence or poor evidence. In some countries, only board-certified forensic specialists are authorized to conduct forensic evaluations. However, the high number of sexual violence cases coupled with the shortage of forensic physicians make that restriction a fundamental impediment to a rights-based response to sexual violence crimes. Governments and regulatory bodies should expand the pool of those capable of conducting forensic sexual violence evaluations by partnering with clinicians of different specialties and facilitating their training.
Media Freedom and the Escalation of State Violence
Authors: Carey Sabine C , González Belén , Mitchell Neil J
Published: June 2021

When governments face severe political violence, they regularly respond with violence. Yet not all governments escalate repression under such circumstances. We argue that to understand the escalation of state violence, we need to pay attention to the potential costs leaders might face in doing so. We expect that the decision to escalate state violence is conditional on being faced with heightened threats and on possessing an information advantage that mitigates the expected cost of increasing state violence. In an environment where media freedom is constrained, leaders can deny or reframe an escalation of violations and so expect to reduce potential domestic and international costs attached to that decision. Using a global dataset from 1981 to 2006, we show that state violence is likely to escalate in response to increasing violent threats to the state when media freedom is curtailed – but not when the media are free from state intervention. A media environment that the government knows is free to sound the alarm is associated with higher political costs of repression and effectively reduces the risk of escalating state violence, even in the face of mounting armed threats.
A Thematic Analysis of Overdose Prevention and Response Efforts in States Experiencing Declines in Rates of Opioid-Involved Overdose Deaths
Authors: Robinson Amber B. , Ali Nida , Costa Olga , Rooks-Peck Cherie , Sorensen-Alawad Amy , Ballard Jonathan , Lowerre Kathryn , Fondario Anna
Published: June 2021

Objective

To address the opioid overdose epidemic, it is important to understand the broad scope of efforts under way in states, particularly states in which the rate of opioid-involved overdose deaths is declining. The primary objective of this study was to examine core elements of overdose prevention activities in 4 states with a high rate of opioid-involved overdose deaths that experienced a decrease in opioid-involved overdose deaths from 2016 to 2017.

Methods

We identified 5 states experiencing decreases in age-adjusted mortality rates for opioid-involved overdoses from 2016 to 2017 and examined their overdose prevention programs via program narratives developed with collaborators from each state’s overdose prevention program. These program narratives used 10 predetermined categories to organize activities: legislative policies; strategic planning; data access, capacity, and dissemination; capacity building; public-facing resources (eg, web-based dashboards); training resources; enhancements and improvements to prescription drug monitoring programs; linkage to care; treatment; and community-focused initiatives. Using qualitative thematic analysis techniques, core elements and context-specific activities emerged.

Results

In the predetermined categories of programmatic activities, we identified the following core elements of overdose prevention and response: comprehensive state policies; strategic planning; local engagement; data access, capacity, and dissemination; training of professional audiences (eg, prescribers); treatment infrastructure; and harm reduction.

Conclusions

The identification of core elements and context-specific activities underscores the importance of implementation and adaptation of evidence-based prevention strategies, interdisciplinary partnerships, and collaborations to address opioid overdose. Further evaluation of these state programs and other overdose prevention efforts in states where mortality rates for opioid-involved overdoses declined should focus on impact, optimal timing, and combinations of program activities during the life span of an overdose prevention program.
Dynamic Changes and Individual Differences in Learners’ Perceptions of Cooperative Learning During a Project Activity
Authors: Yoshimura Masahiro , Hiromori Tomohito , Kirimura Ryo
Published: June 2021

Although cooperative learning is a well-researched framework with many reports on its effective implementation in education, successful cooperative learning practice remains elusive in the classroom. The literature suggests certain elements of cooperative learning are key, but few studies have addressed their importance with respect to the dynamics of the learning activity and differences in individual learners’ attitudes. The objective of this study is to examine (1) whether learners’ perception of cooperative learning changes throughout a project, and (2) how differently individual learners perceive their activities with reference to the five elements (i.e. positive interdependence; face-to-face promotive interaction; individual accountability; social skills; group processing), and thereby to explore measures for successful implementation of cooperative learning. Analyses of a questionnaire survey and weekly journal entries revealed that there were dynamic changes in learners’ perception of cooperative learning in accordance with the shifts in phases of the project. The results also showed that there were significant differences in individual learners’ perceptions and that their engagement in cooperative learning could be affected by certain factors that were not weighed by the five elements. The results of this study can provide hints for better pedagogical interventions for teachers introducing cooperative learning into the classroom.
Protective effects of baicalin on caerulein-induced AR42J pancreatic acinar cells by attenuating oxidative stress through miR-136-5p downregulation
Authors: Zhao Zhu-fen , Zhang Ye , Sun Yang , Zhang Chun-hai , Liu Ming-wei
Published: June 2021

Baicalin, the main active component of Scutellaria baicalensis, has antioxidant and anti-apoptotic effects and is used to treat acute pancreatitis; however, its specific mechanism is unclear. This study aims to determine the protective effect and underlying mechanism of baicalin on AR42J pancreatic acinar cell injury. AR42J acinar cells (caerulein, 10 nmol/L) were induced in vitro to establish a cell model for acute pancreatitis. Cell relative survival was measured by thiazolyl blue tetrazolium bromide, and cell apoptosis and death were examined by flow cytometry. The expression levels of superoxide dismutase1 (SOD1), Bax, survivin, Bcl-2, caspase-3, and caspase-7 proteins were analyzed by Western blot, and those of SOD1 mRNA and miR-136-5p were determined by RT-PCR. The activities of GSH, SOD1, ROS, and MDA were also investigated. Compared with those of the caerulein group, the relative survival rate and activity of AR42J pancreatic acinar cells with different baicalin concentrations were significantly increased ( p < 0.05), and the supernatant amylase level was markedly decreased ( p < 0.05). In addition, the ROS and MDA activities and mir-136-5p expression were significantly decreased, and the GSH activities and SOD1 gene and protein expression levels were markedly increased ( p < 0.05). These results suggest that baicalin reduced the caerulein-induced death of AR42J acinar cells and alleviated the caerulein-induced injury in pancreatic acinar cells by inhibiting oxidative stress. The mechanism may be related to the decreased expression of Mir-136-5p and the increased expression of SOD1 gene and protein.
Writing and exhibiting a ‘live’ and convivial sociology: Portraiture and women’s lived experiences of a French suburb
Authors: Peyrefitte Magali
Published: June 2021

Embracing the manifesto for a ‘live’ sociology, I included portraiture into the research design of an ethnographic study into women’s lived experiences of French suburbia and organised an exhibition entitled Habitantes d’Hier and d’Aujourd’hui: exposition sociologique et photographique. This was a personal project in the neighbourhood of my youth and was motivated by the intention to shine some light on the invisible stories of women living in lower-middle and middle-income suburbs in France. In this article, I reflect on the use of portraiture for the possibility it offers in capturing the ethnographic encounter as well as in giving saliency and offering a visual representation of the sociological analysis. I also discuss the exhibition of these portraits as a moment of conviviality grounded in the endeavour of writing differently from hegemonic modes of academic communication and dissemination allowing for a sharing and sharpening of the sociological imagination. It represents an opportunity to think beyond some of the more neoliberal imperatives that govern academia today and shape our sociological craft. I argue for the value of creating a moment of conviviality, that is a space challenging modes of dissemination, engagement and even impact to some extent, as well as modes of knowledge production: broadly opening up more possibilities for a truly public sociology to continue to exist.
Critical Commentary: Cities in a post-COVID world
Authors: Florida Richard , Rodríguez-Pose Andrés , Storper Michael
Published: June 2021

This paper examines the effect of the COVID-19 pandemic and its related economic, fiscal, social and political fallout on cities and metropolitan regions. We assess the effect of the pandemic on urban economic geography at the intra- and inter-regional geographic scales in the context of four main forces: the social scarring instilled by the pandemic; the lockdown as a forced experiment; the need to secure the urban built environment against future risks; and changes in the urban form and system. At the macrogeographic scale, we argue the pandemic is unlikely to significantly alter the winner-take-all economic geography and spatial inequality of the global city system. At the microgeographic scale, however, we suggest that it may bring about a series of short-term and some longer-running social changes in the structure and morphology of cities, suburbs and metropolitan regions. The durability and extent of these changes will depend on the timeline and length of the pandemic.
Urban rhythms in a small home: COVID-19 as a mechanism of exception
Authors: Preece Jenny , McKee Kim , Robinson David , Flint John
Published: June 2021

The amount of living space we have access to is one manifestation of the unequal distribution of housing resources within societies. The COVID-19 pandemic has required most households to spend more time at home, unmasking inequalities and reigniting longstanding debates about the functionality and experience of smaller homes. Drawing on interviews across three UK cities, this article attends to the changing household routines of individuals living in different types of small home, exploring daily life before and during ‘lockdown’. Using the concept of urban rhythms, the data show that the lockdown has intensified existing pressures of living in a smaller home – lack of space for different functions and household members – whilst constraining coping strategies, like spending time outside the home. Lockdown restrictions governing mobility and contact acted as a mechanism of exception, disrupting habitual patterns of life and sociability, and forcing people to spend more time in smaller homes that struggled to accommodate different functions, affecting home atmospheres. For some, the loss of normal strategies was so significant that they sought to challenge the new rules governing daily life to protect their wellbeing.
Atonement impasse: The perennial problem of communicating Christ’s atonement to Muslims
Authors: Bennett Matthew Aaron
Published: June 2021

For 1400 years, Muslims and Christians in interfaith dialogue have encountered a perennial impasse surrounding the historical account of Jesus’ death. For most Muslims who hold a traditional interpretation of the Qur’an, Jesus did not die on the cross, but was assumed to heaven and another was crucified in his place. For Christians, however, the cross and subsequent resurrection are the center of gospel faith. This article recognizes the impasse over the crucifixion, but proposes that the conceptual distance surrounding the concept of atonement is a prior concern that needs to be addressed before one overcomes the historical question. In order to consider the barriers to communication and mutual understanding surrounding Jesus’ cross, we must first recognize that the qur’anic understanding of atonement presents linguistic, ritual, narrative, and worldview barriers to a biblical understanding of atonement. As such, before one answers the question, “Did Jesus die on the cross?” it is imperative to ask, “Why would Jesus’ death on the cross matter?” This article seeks to explain the distinct understanding of atonement represented in the Qur’an and to propose that the Book of Hebrews is uniquely suited to present a biblical understanding of atonement to one who is influenced by the Qur’an.
Somewhat more than path dependence: The Spanish employers’ peak organisation and social dialogue in light of the crisis of the industrial relations system
Authors: Sánchez-Mosquera Marcial
Published: June 2021

The literature has shown that, much the same as other employers in southern Europe, the Spanish employers’ peak association, the Spanish Confederation of Employers’ Organisations (CEOE), did not take advantage of the radical legislative deregulation of 2010–2012 and, to the contrary, helped perpetuate the traditional institutions that order the industrial relations system. This article contributes to a better understanding of the underlying reasons that guided the CEOE’s behaviour, and also incorporates the Spanish case into the literature on the adaptation of employers’ organisations – and how the institutions and path dependence have an influence – in the face of the widespread trends of economic deregulation. Finally, this article provides up-to-date, solid and reliable data on membership of employers’ associations in Spain, the lack of which is one of the shortcomings of the literature.
Introduction: Beyond the Production of Ignorance: The Pervasiveness of Industry Influence through the Tools of Chemical Regulation
Authors: Henry Emmanuel , Thomas Valentin , Aguiton Sara Angeli , Déplaude Marc-Olivier , Jas Nathalie
Published: June 2021

Research on the influence of industry on chemical regulation has mostly been conducted within the framework of the production of ignorance. This special issue extends this research by looking at how industry asserts its interests––not just in the scientific sphere but also at other stages of policy-making and regulatory process––with a specific focus on the types of tools or instruments industry has used. Bringing together sociologists and historians specialized in Science and Technology Studies (STS), the articles of the special issue study the arenas in which instruments and practical guidelines for public policy are negotiated or used. The aim is to observe the devices in the making or in action, from the selection of actors to the production of thresholds, criteria, and other technical regulations. The introduction highlights how industry influence on expertise and regulation is undoubtedly far more pervasive and multifarious than has been conceptualized to date by social scientists. Putting this issue back at the heart of both the STS and social sciences research agendas is increasingly urgent and could lead to new inquiries able to highlight these logics even more widely, using fresh empirical examples.
Overseas media, homeland audiences: examining determinants of newsmaking in Deutsche Welle’s Amharic Service
Authors: Workneh Téwodros W
Published: June 2021

Historically, the Federal Democratic Republic of Ethiopia’s (FDRE) media environment faced a state apparatus that had been hostile to journalism practice. In particular, government-sponsored intimidation, jailing, and censorship of journalists paralyzed non-state journalistic institutions. With the political establishment’s hostility toward non-state press incapacitating credible journalism internally, foreign-based international and diasporic news outlets have enjoyed considerable following by Ethiopians. In the absence of reliable domestic news sources, Germany’s public international broadcaster Deutsche Welle (DW), alongside the Voice of America, has become arguably the most sought-after source of news in Ethiopia. Through data generated from interviews with newsroom staff, document analysis, and workflow observation, the purpose of this study is to examine newsmaking determinants in DW’s Amharic Service. The study identifies three major factors that influence newsmaking practices at DW Amharic, namely ideological determinants, geographic determinants, and audience-generated determinants. Ideological determinants mainly ascribe to the tensions between the host (Germany) and homeland (Ethiopia), emerging principally from the former’s mission of ‘a democratic export’ and the latter’s resistance to it. Geographic determinants enhanced journalistic safety at the expense of eyewitness reporting and sourcing triangulation. Finally, in engaging with audience-generated determinants, findings reveal how partisan political groups attempt to exert pressure on coverage and the mechanisms the newsroom implemented to navigate externally generated challenges of journalistic autonomy.
Role of trans-radial band protocols in radial artery occlusion: Randomized trial
Authors: Rahman Nasir , Artani Azmina , Baloch Farhala , Artani Moiz , Fatima Huma , Salam Abdus , Ahmed Sher
Published: June 2021

Background

Radial artery occlusion is a common complication of coronary angiography via radial artery, attributed to the prolonged use of trans-radial band post procedure. Literature suggests there is no standard protocol for radial band deflation, and it varies across institutions. However, the protocol suggested by Cohen and Alfonso is widely used globally. This study aims to test whether our hospital’s radial band deflation protocol is non-inferior to the protocol of Cohen and Alfonso, which affirms lesser complications.

Methods

This is an outcome assessor blinded, non-inferiority trial conducted at a tertiary care hospital in Karachi. We enrolled 100 patients who underwent coronary angiography from radial access and gave written informed consent. The intervention group received protocol A, that is in practice at the institution, while the control group received protocol B, developed by Cohen and Alfonso. The primary outcome was occurrence of radial artery occlusion at 24 h. The secondary outcomes included hematoma and bleeding after radial band removal.

Results

The mean age of the participants in the trial was 58.3 ± 11.5 years, while 63% of them were men. Participants in both the groups had similar baseline characteristics. Radial artery occlusion was not significantly different between protocol A and protocol B (10% vs. 14%, p = 0.49, respectively). Similarly, hematoma and bleeding after trans-radial band removal showed no statistical difference between the groups.

Conclusion

Trans-radial band deflation practice at our institution was non-inferior to Cohen and Alfonso’s protocol in the incidence of radial artery occlusion after coronary angiography.

Trial Registration Number

This trial is registered at clinicaltrials.gov ( https://clinicaltrials.gov ) with registration number NCT03298126.
Male and Female Conceptualizations of Sexual Harassment in Tanzania: The Role of Consent, Male Power, and Social Norms
Authors: Wamoyi Joyce , Ranganathan Meghna , Mugunga Samuel , Stöckl Heidi
Published: June 2021

Sexual harassment is pervasive worldwide, yet there is a lack of clarity on its conceptualization in many settings, especially in low-income countries. Context-specific conceptualization of sexual harassment is vital to develop effective measurement tools, estimate its magnitude, and the design of interventions to address it. We explored how different population groups in Mwanza, Tanzania, understood, conceptualized, and experienced sexual harassment. This study employed a qualitative research design involving 74 in-depth interviews and 13 focus group discussions with participants from educational, workplace, and public settings in Mwanza, Tanzania. Participants were adolescent girls and boys, adult women and men. We explored individual-level perceptions and experiences of sexual harassment, and community norms and expectations around sexual harassment. We analyzed the data using a thematic approach. Participants’ perceptions of sexual harassment emphasized the critical role of consent, the expression of male power, and social norms with regard to sexual harassment. Sexual harassment was understood to be a result of men being in positions of power and in charge of material resources, school grades, or employment opportunities. These in turn enabled them to take advantage of girls and women. Social norms around male and female interactions, courtship and seduction, expressions of sexual interest were crucial in delineating what was and what was not considered sexual harassment. Sexual harassment is a fluid concept, and its definition is highly dependent on contextual factors. Consent underpins the conceptualization of sexual harassment and is a fundamental feature in the definition and measurement of sexual harassment in Tanzania. Consent is largely determined by sexual norms around male and female interactions and gendered power. There is a need for consensus in schools, workplaces, and communities about what constitutes sexual harassment in order to measure and address it appropriately.
The Levels of SARS-CoV-2 Specific Antibodies in Human Milk Following Vaccination
Authors: Juncker Hannah G. , Mulleners Sien J. , van Gils Marit J. , de Groot Christianne J. M. , Pajkrt Dasja , Korosi Aniko , van Goudoever Johannes B. , van Keulen Britt J.
Published: June 2021

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being administered around the world; however, lactating women were excluded from SARS-CoV-2 vaccine trials. Therefore, knowledge about the effect of vaccination in this specific group is limited. This information is essential to empower lactating women to make a well-informed decision on their choice for vaccination. After natural infection, SARS-CoV-2 specific antibodies are present in human milk, which might offer protection for her newborn. The dynamics of these antibodies in human milk following vaccination remain to be elucidated.

Research Aim

To determine the effect of vaccination with BNT162b2 on the levels of SARS-CoV-2 specific IgA in human milk.

Methods

In this prospective longitudinal study, we included lactating women who received the BNT162b2 vaccine. Human milk samples were collected prior to vaccination and 3, 5, 7, 9, 11, 13, and 15 days after both vaccine doses. Samples were analyzed using enzyme-linked immunosorbent assay against the spike protein of SARS-CoV-2.

Results

In total, 366 human milk samples from 26 lactating women were analyzed. A biphasic response was observed, with SARS-CoV-2 specific immunoglobulin A (IgA) starting to increase between day 5 and 7 after the first dose of the vaccine. After the second dose, an accelerated IgA antibody response was observed.

Conclusion

After vaccination with the mRNA-based BNT162b2 vaccine, a SARS-CoV-2 specific antibody response was observed in human milk. The presence of SARS-CoV-2 specific IgA after vaccination is important as antibodies are transferred via human milk, and thereby might provide protection to infants against COVID-19.
Not All High-Growth Firms Are Alike: Capturing and Tagging Ohio’s Gazelles
Authors: Piazza Merissa C. , Hill Edward (Ned)
Published: June 2021

In this study, the authors present a statistically valid typology of high-growth firms (HGFs), also known as gazelles, to determine if payroll and job growth patterns differ between groups or clusters. Cluster–discriminant analysis was conducted on a cohort of 26,104 HGFs s in Ohio, using data from the Quarterly Census of Employment and Wages from 2010 to 2015. Only 1.2% of all Ohio’s firms can be classified as high growth. The larger herd of gazelles grows consistently, while the other, much smaller pack experiences short, intense growth spurts. Roughly 30% of the two gazelle clusters (Consistent High Growth and Volatile High Growth) are in the information service, financial service, and professional and business service industries, compared with 18% in the low- and slow-growth cluster. The nongazelle HGF cluster has proportionately more businesses in manufacturing and the leisure and hospitality industries than the gazelle clusters.
Multi-objective reliability-based optimal synthesis of path generating four-bar mechanisms: A cooperative game theoretic approach
Authors: Ahmadi Bahman , Ahmadi Behzad , Chegini Saeed Nezamivand , Safari Leili
Published: June 2021

In this study, a novel approach based on synergy of cooperative game theory, reliability-based design optimization (RBDO) and Monte Carlo simulation (MCS) is proposed to address the reliability-based multi-objective optimal synthesis of path generating four-bar mechanisms, taking into account the influence of dimensional uncertainty on the reliability of mechanism. Tracking error ([Formula: see text]), deviation of transmission angle from 90° ([Formula: see text]) and probability of failure of Grashof constraint are defined as three performance criteria whose minimization enhance the precision, quality of motion and reliability of mechanism, respectively. To do so, three objective functions are considered, namely, precision ([Formula: see text]), quality of motion ([Formula: see text]) and reliability ([Formula: see text]); each objective function is assigned to a player. To conduct the optimization procedure, a game model is proposed, in which the cooperative game scenario is employed by defining a Nash bargaining function to model the interaction between players. In this way, the three-objective optimum design of mechanism is cast into a single-objective optimization problem. The comparisons of the obtained results using the method of this research with those reported in the literature shows a significant improvement in reliability of mechanism, whilst both precision and quality of motion in deterministic design is maintained. Particularly, the tracking error and the deviation of transmission angle from 90° of the synthesized mechanism is 0.0006 and 666.36 respectively, whilst the reliability is guaranteed since no violation of Grashof constraint occurs in the presence of 10% parameter uncertainty.
Non-invasive thyroid detection based on electroglottogram signal using machine learning classifiers
Authors: Sai P Vijay , Rajalakshmi T , Snekhalatha U
Published: June 2021

Thyroid is a butterfly shaped gland located in the neck region. Hormones are secreted by the thyroid gland that is responsible for various functions that maintain metabolism of the body. The variance in secretion of the hormones causes disorders such as Hyperthyroidism or Hypothyroidism. Electroglottography signal is a bio signal which represents the impedance that exist between the glottis regions. The study aims at design and development of an hardware circuit for the acquisition of Electroglottogram signal from normal and thyroid subjects is proposed followed by feature extraction from the acquired bio signal is performed. Further, machine learning classifiers were used to classify the normal and thyroid individuals. This modality of acquisition is non-invasive. Performance evaluation is done by testing various classifiers to study the accuracy. The classifiers tested were Random Forest, Random Tree, Bayes Net, Multilayer Perceptron, Simple Logistic classifier, and One-R classifier. Classifiers such as Random Forest, Random Tree, and Multilayer Perceptron showed high accuracy. The accuracy estimated by these classifiers was tested and its ROC curves with AUC scores were derived. The highest accuracy was reported for Simple Logistic classifier which was about 95.1%. Random Forest and Random Tree reported 93.5% and 91.9% respectively. Similarly, Multilayer Perceptron and Bayes Net gave 93.5% and 91.9%. The One-R classifier algorithm reported the lowest accuracy of 90.3% among the studied classifier algorithms. The ROC-AUC score for the classifiers were also reported to be more than 0.9 which is considered more promising and supports the acquisition and processing methodology. Hence the proposed technique can be efficiently used to diagnose thyroid non-invasively.
Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy
Authors: Hur Junseok W , Kim Min-Sik , Oh Se-Yeon , Kang Ho-Young , Bae Jingi , Kim Hokeun , Lee Hangyeore , Lee Sang-Won , Park Dong-Hyuk
Published: June 2021

Human adipose-derived mesenchymal stem cells (hAMSCs) are capable of immunomodulation and regeneration after neural injury. For these reasons, hAMSCs have been investigated as a promising stem cell candidate for stroke treatment. However, noninvasive experiments studying the effects of grafted stem cells in the host brain have not yet been reported. Cerebrospinal fluid (CSF), which can be collected without sacrificing the subject, is involved in physiological control of the brain and reflects the pathophysiology of various neurological disorders of the central nervous system (CNS). Following stem cell transplantation in a stroke model, quantitative analysis of CSF proteome changes can potentially reveal the therapeutic effect of stem cells on the host CNS. We examined hAMSC-secreted proteins obtained from serum-free culture medium by liquid chromatography-tandem mass spectrometry (LC-MS/MS), which identified several extracellular matrix proteins, supporting the well-known active paracrine function of hAMSCs. Subsequently, we performed label-free quantitative proteomic analysis on CSF samples from rat stroke models intravenously injected with hAMSC (experimental) or phosphate buffered saline (control). In total, 524 proteins were identified; among them, 125 and 91 proteins were increased and decreased with hAMSC treatment, respectively. Furthermore, gene set enrichment analysis revealed three proteins, 14-3-3 theta, MAG, and neurocan, that showed significant increases in the hAMSC-treated model; these proteins are core members of neurotrophin signaling, nerve growth factor (NGF) signaling, and glycosaminoglycan metabolism, respectively. Subsequent histological and neurologic function experiments validated proliferative neurogenesis in the hAMSC-treated stroke model. We conclude that (i) intravenous injection of hAMSCs can induce neurologic recovery in a rat stroke model and (ii) CSF may reflect the therapeutic effect of hAMSCs. Additionally, proteins as 14-3-3 theta, MAG, and neurocan could be considered as potential CSF biomarkers of neuroregeneration. These CSF proteome profiling results would be utilized as valuable resource in further stroke studies.
After the crisis is before the crisis: Reading property market shifts through Amsterdam’s changing landscape of property investors
Authors: Taşan-Kok Tuna , Özogul Sara , Legarza Andre
Published: June 2021

Shifts in property markets are closely tied to changes in investment actors’ relations, shaped by wider economic and regulatory processes. However, the existing literature generally neglects the role of actors’ behaviour and agency within property market shifts, and how market shifts affect cities. In response, we establish a framework that systematically unpacks the role, characteristics and behaviour of property investors in investment market shifts within urban development. We consider market shifts as modifications to established economic and regulatory processes and argue that a multidimensional approach is required to understand property investors and their role within property investment markets that shapes the urban built environment. Our main contribution is a novel approach and methodology to read changing property investor landscapes by linking wider economic and regulatory changes to investment actors and their investment strategies. Empirically, we focus on Amsterdam’s changing investor landscape over the last 15 years. We investigate how crises, represented by far-reaching institutional disruptions of economic and regulatory systems, relate to Amsterdam’s landscape of property investors. Correspondingly, we define three distinct periods of analysis, based on transaction volumes and regulatory interventions at national and local levels: the pre-global financial crisis (GFC) period from 2005 to 2008, the post-GFC recovery period from 2009 to 2013, and the pre-Covid19 boom period from 2014 to 2020. We reveal how Amsterdam’s investor landscape changed over the course of these periods through a mixed methods analysis, including quantitative investment transaction analysis, mapping, and in-depth interviews with investors. We ultimately suggest that reading property market shifts through multidimensional characteristics would enable more targeted policy solutions, moving away from empirically ill-supported stereotypes of property actor behaviours.
Reliability and reliability-based sensitivity analysis of self-centering buckling restrained braces using meta-models
Authors: Hashemi Seyede Vahide , Miri Mahmoud , Rashki Mohsen , Etedali Sadegh
Published: June 2021

This paper aims to carry out sensitivity analyses to study how the effect of each design variable on the performance of self-centering buckling restrained brace (SC-BRB) and the corresponding buckling restrained brace (BRB) without shape memory alloy (SMA) rods. Furthermore, the reliability analyses of BRB and SC-BRB are performed in this study. Considering the high computational cost of the simulation methods, three Meta-models including the Kriging, radial basis function (RBF), and polynomial response surface (PRSM) are utilized to construct the surrogate models. For this aim, the nonlinear dynamic analyses are conducted on both BRB and SC-BRB by using OpenSees software. The results showed that the SMA area, SMA length ratio, and BRB core area have the most effect on the failure probability of SC-BRB. It is concluded that Kriging-based Monte Carlo Simulation (MCS) gives the best performance to estimate the limit state function (LSF) of BRB and SC-BRB in the reliability analysis procedures. Considering the effects of changing the maximum cyclic loading on the failure probability computation and comparison of the failure probability for different LSFs, it is also found that the reliability indices of SC-BRB were always higher than the corresponding reliability indices determined for BRB which confirms the performance superiority of SC-BRB than BRB.
Tinkering With the Plumbing of Sustainable Enterprises: The Case for Field Experimental Research in Corporate Sustainability
Authors: Spicer Andrew , Wagner Marcus , Zollo Maurizio
Published: June 2021

In this introduction, we first review the lessons learned in development economics about the ability of randomized control trials to analyse what Duflo refers to as the “plumbing problems” of policy implementation, as opposed to “engineering problems” of policy design. We then examine the papers published within this special issue from a plumbing-based perspective to highlight the benefits of the co-creation of knowledge in corporate sustainability through a field-based experimental agenda. We finally propose that field-based experiments can radically influence the future development of our (and related) fields of inquiry in three ways: (1) focusing on the implementation processes of sustainability strategies, (2) shifting attention from the analysis of past events to the design of future actions, and (3) yielding our role as sole owners of the knowledge development process and agreeing to shared ownership with the organizations we study.