bluuebunny/crossref_metadata_2025 huggingface dataset:
Los procesos contables y su incidencia en el control de inventarios en las clínicas veterinarias de la ciudad de Portoviejo – Ecuador.
Authors: Arteaga-Macías Johanna , Palma-Macías Gregorio
Published: March 2023

Las clínicas veterinarias deben mantener una adecuada gestión de inventarios de productos desde los costes de laboratorio hasta los insumos a la venta con el propósito de hacer reducción y optimización de costos. El objetivo de la investigación fue analizar la incidencia de los procesos contables en el control de inventarios de las clínicas veterinarias de la ciudad de Portoviejo – Ecuador. La investigación fue de campo-descriptiva, el diseño  no  experimental-  transversal,  con una  población  de  9  trabajadores  de tres Clínicas Veterinarias de la Ciudad de Portoviejo. Se aplicó encuesta a los trabajadores y entrevista a los propietarios con la finalidad de evidenciar la importancia del control de inventarios para manejar una contabilidad productiva desde el capital invertido hasta los productos en riesgo, permitiendo identificar los productos con mayor rotación y que generaron mayor utilidad.

Se concluye que los procesos contables y el control de inventarios son herramientas importantes para toda empresa, tienen como propósito obtención de resultados favorables que garantizan un control adecuado de los inventarios.
Las competencias de los docentes investigadores en Educación Inicial
Authors: Baque-Pibaque Liliana
Published: March 2023

El estudio realizado implica a las competencias de los docentes investigadores como estimulo para la Educación Inicial, desde esta perspectiva, es necesario contribuir a esta formación para lograr el desarrollo del perfil profesional de jóvenes y profesionales. Se determino como principal objetivo elaborar un programa de estudio de las competencias investigativas como estímulo para fortalecer la formación docente de Educación Inicial de la Universidad de Guayaquil. Para lograr este objetivo se emplearon métodos de investigación como analítico, sintético, inductivo – deductivo, enfoque cuantitativo y paradigma positivista, tipo descriptivo. De los empíricos estudio documental, observación, encuesta. Esto garantizó los principales resultados sobre las definiciones de competencias de docentes investigadores en la Educación Inicial necesarios para el desarrollo de conocimientos en la resolución de problemas sociales que la docente utilice las estrategias adecuadas para favorecer el desempeño de los jóvenes y profesionales para responder necesidades del contexto, y  de manera eficiente resolver los problemas, logrando que las docentes tengan una mejor redacción en sus escritos, fluidez en la expresión escrita.
Valores del gerente público en la administración pública: Un significado aproximado desde los principios de la responsabilidad
Authors: Fernandez-Parraga Jose , Rivera-Prado María
Published: March 2023

La investigación tuvo como propósito Interpretar los valores del gerente público desde el discurso de expertos investigadores; y las siguientes directrices: Identificar los valores con que la que el gerente público reflexiona cotidianamente, comprender la visión del gerente con la administración pública desde una perspectiva de los valores, y revelar los valores del gerente público en la administración pública; la misma fue desarrollada en el contexto de la realidad de las instituciones públicas en la provincia de Manabí; la investigación es de enfoque cualitativa e inductiva, con una estrategia de revisión documental basada en la triangulación entre las teorías revisadas, los criterios de los investigadores, y lo aportado por los informantes claves en las entrevistas, dando espacio a un nuevo constructo el cual se da bajo una propuesta de buena praxis dentro de la administración pública; su nivel de profundidad es de tipo descriptiva; se da un aporte sustantivo por parte de los entrevistados a través de su narrativa, ampliando la comprensión en materia de gerencia pública y los valores que tienen sus responsables. La estrategia de análisis se da desde lo propuesto por la Teoría Fundamentada; por otro lado, la posibilidad de tener un valioso discurso suministrado por los entrevistados, ha dado paso a una metódica interpretativa desde la hermenéutica, contribuyendo al proceso de entender, comprender e interpretar la narrativa expuesta; como hallazgo surgen dos vertientes para una buena praxis en la gestión pública: 1.- Modelo cultural de gerencia pública, y 2.- Gerente público disruptivo.
Analisis Kelayakan Perumahan Subsidi Pada Kota Lhokseumawe: Studi Kasus Perumahan Palapa Village Dan Griya Putri Grand
Authors: Rinaldi Wahyu , Fahrizal Effan , Olivia Sisca , Novianti Yenny
Published: March 2023

The rapid population growth in developing cities is caused by the large number of immigrants who settle and live there. This case also occurred in Lhokseumawe City, the center of district administration, education, economy and trade on the east coast of Aceh. This condition makes housing development a fundamental need for everyone. The government ensures everyone can own and live in a livable, healthy house with low prices. The government is trying to overcome this by building subsidized housing assisted by the developer so that the middle to the lower economic community can still own and live in a house that follows the existing standard provisions so that it can be said to be a livable house. This study aims to determine the suitability of subsidized housing that has been built based on the standard criteria for building healthy simple houses and the provision of facilities and infrastructure. Qualitative descriptive methods are used to observe and analyze objects based on applicable standards, housing health requirements, and technical guidelines for constructing simple healthy houses and SNI for environmental planning in urban housing. The analysis result defines that the research objects (Palapa Housing and Griya Housing) have followed the standard of healthy simple houses, facilities and infrastructure. Several variables are found inappropriate, such as parks, drainage and waste management at Palapa Housing and parks and clean water supply at Griya Housing. Residents should adapt to the lack or non-compliance of these housing standards.
Evaluasi Layanan Jalur Sepeda pada Rute Jalan Ryacudu Kota Bandarlampung
Authors: Romadhon Rio Abdullah , Murwadi Haris
Published: March 2023

The City Government of Bandar Lampung has made several routes for bicycle lanes including the Jalan Ryacudu Route. This path is quite busy used by cyclists for their various purposes. This study aims to determine the dominant factor in the level of satisfaction with bicycle lane services and to determine differences in levels of community satisfaction regarding bicycle lane services on the Ryacudu Road route. The method used in this research is descriptive quantitative method. Data collection was carried out through a closed questionnaire on 441 respondents. The data were analyzed using distribution analysis, analysis and analysis of variance (ANOVA). The results showed that 1) the dominant variables that influence the evaluation of bicycle lane services include: lane arrangement (3.95), convenience from traffic (3.91), and comfort in bicycle lane conditions (3.87). 2) The difference in the level of significant satisfaction occurs in the mileage variable. Medium mileage (5-10 and 11-15) tends to have a high level of satisfaction.
Evaluating factors affecting the distribution and timing of Pacific herring Clupea pallasii spawn in British Columbia
Authors: Rooper CN , Boldt JL , Cleary J , Peña MA , Thompson M , Grinnell M
Published: March 2023

Pacific herring Clupea pallasii spawn in nearshore areas in late winter to early spring, but factors influencing the timing and spatial distribution of spawning are not well known. We modeled the temporal and spatial distribution of spawning for 5 herring stocks in British Columbia from egg deposition surveys conducted from 1988-2018 using different sets of environmental predictors and modeling methods. Random forest modeling showed that the timing of spawning in each year was mainly influenced by the number of daylight hours being >10.5, cumulative degree days >100 and salinity at 30.5. The spatial distribution of spawning tended to occur at consistent locations over time. Results showed that the probability of spawning occurring at a transect in a given year was largely determined by the biomass of herring and location of the transect relative to the center of spawning. Environmental factors at individual transects played a much smaller role in determining spawn distribution. There was mixed evidence for spatial expansion of spawning distribution in years of high biomass, with some stocks, such as Haida Gwaii, showing no expansion of the spawning area in years of higher biomass. Since Pacific herring recruitment has been linked to their ability to time larval hatch to spring bloom timing, future warming temperatures may result in earlier herring spawning relative to the spring bloom. This will increase the probability of mismatch with prey, impacting larval herring starvation, growth and perhaps mortality, leading to reductions in recruitment to these important stocks.
Across the North Pacific, dietary-induced stress of breeding rhinoceros auklets increases with high summer Pacific Decadal Oscillation index
Authors: Shimabukuro U , Takahashi A , Okado J , Kokubun N , Thiebot JB , Will A , Watanuki Y , Addison B , Hatch SA , Hipfner JM , Slater L , Drummond BA , Kitaysky AS
Published: March 2023

Multi-colony studies of breeding seabirds may provide insights into the mechanistic links between large-scale climate variability and local changes in prey availability. In the North Pacific, the Pacific Decadal Oscillation (PDO) is a dominant climate index characterized by contrasting patterns in sea surface temperature between the western and eastern North Pacific. To examine how inter-annual variability in the PDO affects rhinoceros auklets Cerorhinca monocerata across the North Pacific, we measured inter-annual changes in nutritional stress (as reflected in plasma levels of corticosterone) of adults breeding on 5 colonies (2 and 3 colonies from the western and eastern Pacific, respectively). We also examined concurrent changes in mass and energy content of food loads delivered to chicks. We found that higher summer PDO values were associated with increased corticosterone levels and lower mass and energy contents of the food loads in both the western and eastern North Pacific colonies. Results indicated that oceanographic conditions during higher PDO values induced local changes in forage fish communities, leading to reduced prey availability, which, in turn, increased the nutritional stress of breeding birds. We conclude that the higher summer PDO index in recent years was associated with food-poor conditions for breeding rhinoceros auklets across their reproductive range, and prolonged periods of high summer PDO may be detrimental to the populations of this seabird species. Our results highlight the complexity of the mechanisms of how large-scale climate variability affects seabirds with a large geographical distribution.
Prostatic Inflammation is Determinant for Prostate Overgrowth and Luts Severity in Men with Metabolic Syndrome: Highlights from Two Recently Published Multicentre Studies
Authors: Gacci Mauro , Sebastianelli Arcangelo , Salvi Matteo , Carini Marco
Published: March 2023

Introduction: Several evidences have pointed out the possible association between Metabolic Syndrome (MetS) and low urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH). Recent epidemiological and histopatological evidences suggested chronic inflammation is a crucial event in BPH pathogenesis. Aim of this study is to demonstrate the correlation among pre-operatory LUTS/BPH severity, MetS features and inflammatory infiltrates in prostatectomy specimens of patients with BPH, highlighting the results of two recently published multicentre studies analyzing all the data from a preclinical and clinical point of view.
Materials and methods: We conducted two retrospective study in 271 and 244 consecutive men treated with simple prostatectomy for LUTS/BPH in two tertiary referral centres. Prostate diameters and volume were measured by transrectal ultrasound, LUTS were scored by IPSS, and obstruction diagnosed by uroflowmetry. MetS was defined according to DF & AHA/NHLBI criteria. The inflammatory infiltrate was investigated according to the scoring system of chronic prostatitis (CP-CPPS) and scored as inflammation score (IS) ranging 3 to 9 and glandular disruption (GD). In addition, we investigated the in vitro inflammatory effects of metabolic insults on human prostatic myofibroblast cells isolated from BPH patients (hBPH).
Results: Of 271 men, 86 (31.7%) were affected by MetS. Prostatic volume and the anterior-posterior (AP) diameter were positively associated to the number of MetS components. Among MetS determinants, only dyslipidaemia (increased serum triglycerides and reduced serum HDL levels) was significantly associated with an increased risk of having a prostatic volume >60cm3. IS in prostatectomy specimens showed a step- wise association with number of MetS factors (p=0.001). Dyslipidaemia was the only factor significantly associated with IS. Positive significant correlations among MetS, IS, GD and IPSS Scores were observed. In myofibroblastic hBPH oxidized low-density lipoprotein (oxLDL) showed the highest secretion of IL-8 (>10-folds)-a surrogate marker of prostate inflammation-as well as IL-6, and bFGF.
Conclusions: MetS and dyslipidaemia are associated with prostate overgrowth and inflammation. In particular, with a selective increase of prostatic AP diameter, leading to a modification of prostatic shape. Hence, MetS can be regarded as a new determinant of prostate inflammation and BPH progression in men with severe LUTS.
Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer
Authors: Syvänen Kari T. , Järveläinen Hannu , Taimen Pekka , Laato Matti , Boström Peter J.
Published: March 2023

Neoadjuvant chemotherapy (NAC) in muscle-invasive bladder cancer was introduced several years ago. Despite the evidence supporting its use in clinical practice, only a minority of patients who undergo radical cystectomy receive preoperative chemotherapy. In addition, recommendations and methods to detect patients who would benefit the most from NAC are still unclear. The European Association of Urology (EAU) guidelines panel on muscle-invasive and metastatic bladder cancer recommends the use of cisplatin-based NAC for T2-T4a, cN0 M0 bladder cancer if the patient has a performance status ≥2 and if the renal function is not impaired, but the American Urological Association, for example, does not have any guideline recommendations on this topic at all. In this review we describe the current literature supporting NAC in association with radical cystectomy in muscle-invasive urothelial carcinoma of the bladder. Evidence acquisition was made searching the Medline database for original articles published before 1st February 2014, with search terms: “neoadjuvant chemotherapy”, “radical cystectomy”, and “invasive bladder cancer”.
Health And Wellbeing Impact And Treatment of Nocturia – A Review of The Literature
Authors: Osman Nadir I. , Hillary Christopher , Chapple Christopher R.
Published: March 2023

Nocturia is a prevalent and highly bothersome lower urinary tract symptom (LUTS) affecting men and women of all ages. In waking to void there is disruption to an individual’s sleep that can lead to daytime tiredness and a loss of vitality. This may significantly impact upon physical, mental, and social wellbeing. It is recognised that nocturia has a multifactorial aetiopathogenesis that encompasses systemic, psychogenic, as well as lower urinary tract factors, necessitating separate evaluation to other LUTS. In particular, nocturnal polyuria is an under-recognised cause of nocturia that may respond well to antidiuretic pharmacotherapy.
Recurrent Urinary Tract Infections: Can Immunoactive Prophylaxis Improve Disease Management In Healthy Women?
Authors: Legg Ewen
Published: March 2023

This educational summit, supported by an independent grant from OM/Vifor Pharma, brought together experts in the field of urology and gynaecology from Europe and Latin America to meet and discuss the cutting edge management of patients suffering from recurrent urinary tract infections (rUTIs). The meeting included plenary lectures as well as workshops and interactive sessions, allowing delegates and presenters to debate the most pressing international and local issues in the field.

UTIs are one of the most prevalent bacterial infections and are the most common type of infection in healthy adult women, affecting 50% of them at least once in their lifetime.1 The level of antibacterial resistance in common uropathogenic organisms is reaching alarming levels2 and the importance of prophylaxis in the context of increasing resistance cannot be overstated. The current three-tiered approach taken by the European Association of Urology (EAU) for UTI prevention consists of: counselling and behavioural modification, followed by non-antimicrobial prophylaxis, and eventually antimicrobial prophylaxis.3 For many women, counselling and behavioural modification will not be enough to prevent rUTIs, resulting in a need for effective non-antimicrobial therapies which spare antibiotic use and reduce the risk of engendering further resistance in uropathogens. OM-89, a bacterial-lysate-based therapy, currently has the grade of recommendation B in the EAU guidelines for non-antimicrobial prevention of rUTI in otherwise healthy women.3 In the following report we will summarise the putative immunostimulatory mechanism of OM-89 and review the evidence for its efficacy in preventing rUTIs in healthy pre and post-menopausal women.
Practice Patterns for Improving Outcomes in Women with Ileal Neobladder: An Evidence-Based Analysis
Authors: Gakis Georgios
Published: March 2023

Introduction: The aim of this review is to provide practice pattern on how to obtain best possible oncological and functional outcomes in women with orthotopic neobladder substitutes.
Evidence Synthesis: The treating surgeon has to balance oncological and functional risks as well as patient´s preferences and the final decision must be based on consent between the surgeon and the patient. Long- term survival can be achieved in the majority of neobladder patients even with extravesical, node-negative disease. Therefore, surgeons should not be reluctant to proceed with an ileal neobladder in patients with locally advanded tumour stage excluding T4b stage, any positive soft tissue surgical margin and bulky lymph node disease. During preoperative work-up, women with a positive bladder neck biopsy may be still candidates for an orthotopic neobladder unless a carefully obtained full-thickness biopsy of the urethra reveals evidence of malignancy. The key issue in the follow-up of women with neobladder is to achieve a neobladder capacity of 400-500mL, residual free voiding of sterile urine and the elimination of any outlet or upper tract obstruction. Medical conditions (i.e. arterial hypertension, diabetes mellitus) can also cause renal deterioration in the long-term and therefore demand early and thorough treatment.
Conclusions: The clinical background of the treating urologist is of paramount importance for appropriate patient selection, accurate surgical performance and adequate monitoring of women with ileal neobladders. A high level of patient compliance and willingness to undergo follow-up examinations at regular intervals is mandatory for improved outcomes.
The Many Faces Of mCRPC- Assessing Patient Profiles and Tailoring Treatment in a Changing Landscape
Authors: Mughal Tabasum
Published: March 2023

The Bayer-sponsored satellite symposium brought together a range of experts in the field of metastatic castrate-resistant prostate cancer (mCRPC), including Professors Fred Saad, Joe O’Sullivan, Anders Bjartell, Wolfgang Loidl, and Manfred Wirth. This distinguished faculty came together to discuss the changing paradigm and therapeutic options available in the management of mCRPC, offering the opportunity for interactive audience participation to discuss the current treatment landscape.
All-Solution-Processed OLEDs Using Printed Ag Electrodes and a PEI Bonding Layer
Authors: Moon Cheol-Hee
Published: March 2023

We demonstrated a bonding technology using polyethyleneimine (PEI) as a bonding layer between printed Ag electrodes and an emission material layer (EML) to fabricate all-solution-processed Organic LightEmitting Diodes (OLEDs). We manufactured Ag electrodes on a glass substrate by the screen printing method, which was bonded to another substrate with ITO anodes and an EML layer using a PEI layer. Since the bonding layer needs to have both good bonding characteristics and electrical conductivity, we investigated how both characteristics were affected by some experimental factors, namely, PEI concentration, the thickness of the layer and additives. The bonding strength and the electrical current density were investigated by tensile tests and electron only device (EOD) experiments, respectively. The results showed that at higher PEI concentration the bonding strength reached a higher value, but the electrical current through the PEI layer decreased rapidly with increased PEI layer thickness. When sorbitol was added into the PEI solution, both bonding strength and electrical conductivity were improved, and when 10 wt% of sorbitol was added into 0.1 wt% PEI solution, the device showed an electrical current density of 1,000 mA/cm2 and a good bonding strength also. Finally, we manufactured a two-substrate OLED device using the bonding layer and measured the luminance, which revealed that the device turned on at 4 V and the maximum luminance was 7,000 cd/m2. These data, both electrical and optical, demonstrate the potential to fabricate all-solution-processed OLEDs using the two-substrate bonding technology.
Relationship between Fine Motor Skill and the Use of Gadget in Pre-school Age Children
Authors: Hartati Sri Indah Yuli , Awaludin Sidik , Rahmawati Eni
Published: March 2023

Aims: To analyze the relationship between fine motor skill and the use of gadget in pre school age children.
Methods: This study used a cross-sectional design. Sampling technique using quota sampling and the sample in this study amounted to 82 pre school age children in  Purwanegara, Banyumas on March-April 2022. The adopted questionnaire used to be measured use of gadgets application and abilities acceptable fine motor be measured using Denver II. Data analyzed univariate and bivariate using Gamma Test.
Results: The univariate analysis showed that there were eight respondents (9.8%) with gadgets application in the category low, 13 respondents (15.9%) moderate, and 61 respondents (74.4%) high. Denver II results showed fine motor as much as one respondent (1.2%) in category advance, 24 respondents (29.3%) caution, 56 respondents (68.3%) delayed, and one respondent (1.2%) normal. The Gamma test showed a relationship between fine motor skill and the use of gadget  in pre school age children with a p-value = 0,005 (p value<0.05).
Conclusion: There is a significant relationship between fine motor Skill and the use of gadget. Based on these results, periodic developmental screening and nursing interventions are needed to address fine motoric disorders in preschool-aged children who use gadgets, and it is expected that parents will limit the use of gadgets.
Honey for The Treatment of Diabetic Foot: A Literature Review
Authors: Wasilah Hinin , Farida Lisnawati Nur , Darni Zahri
Published: March 2023

Background: Honey known as wound healer, but the use of honey for diabetes population is lack. Scientific studies needed to provide enough evidence to justify the benefits of honey for the treatment of diabetic foot ulcers.
Aims: To identify the benefit of honey as healing diabetic foot ulcer.
Methods: The author was used PICO question as the first step of this study, then the second step was searching the articles from several databases. The inclusion and exclusion criterias were using only honey as a diabetic foot treatment on human, randomized control trial study or quasy experimental study, published less than 10 years ago (2009 – 2019), available in English and provide full text. Meanwhile, for the exclusion criteria were literature review, systematic review or meta-analysis study, using honey as a treatment to animal such as rat and rabbit, combine honey with another treatment. By using PRISMA guideline, researchers were systematically review several articles from 4 databases.
Results: After conducted search strategy by using Boolean search strategy, 4 articles were included. The articles used different types of honey and the population ranged from 8 to 63 peoples. According to the results, majority of study showed honey is effective as wound healer and safe
Conclusion:  Honey wound dressing is an option for managing diabetic foot
Recommendation: As a nurse, we can offer the honey as an effective treatment or intervention tools for targeted patients or populations
Knowledge-related Human Papillomavirus Vaccination: A Study of Indonesian Women
Authors: Mutiar Astri , Wulandari Tiara , Nurhayati Nunung , Marfuah Dewi , Noor Hayati Suci
Published: March 2023

Aims: Human papillomavirus (HPV) is a sexually transmitted virus that can lead to various diseases, most known as cervical cancer’s etiology. HPV vaccination is one of the primary prevention strategies to reduce HPV transmission. To increase vaccination rates, it is essential that women have a good knowledge of receiving the HPV vaccine. The purpose of the study was to explore the knowledge of HPV vaccination among Indonesian women.
Methods: A cross-sectional study was conducted among 462 Indonesian women recruited by convenience sampling on March to May 2022.  The adapted questionnaire of knowledge with 28 items was used with Cronbach's Alpha score estimated at 0.838. Women who are 15 to 49 years old, able to understand and speak the Indonesian language, and have a gadget were included in this study. Women who already get HPV vaccination are excluded.  Univariate statistics were used to describe Indonesian women’s knowledge of HPV Vaccination.
Results: The research shown that the mean age of the respondents is 23.17± 5.065. Half of the respondent level of education is college as many as 245 people (53%). Half of the respondents are employed as many as 239 people (51.7%). The average knowledge is 16.02 with a standard deviation (SD) of 6.43, the knowledge value indicates less knowledge of HPV vaccination among women. In the item analysis, found that most respondents answer incorrectly to the question “HPV testing is done to show whether the HPV vaccine is needed?" (4.3%). Most of the respondents shown did not know answered the question "HPV vaccine requires three doses" (59.3%). Most of the reasons for refusing to be vaccinated answered that the price of the vaccine was not affordable (45.5%).
Conclusion: Women’s knowledge of the HPV vaccine was nearly low in this study. The campaign and effort to spread the information related to HPV vaccination are needed.  Innovative media might be the best option to spread awareness. Studies with a large sample and broad range of area are preferable.
MENCIPTAKAN IKLIM HARMONISASI KOMUNIKASI ORGANISASI UNTUK OPTIMALISASI KINERJA PEGAWAI ADMINISTRASI
Authors: Hikmalia Wilda , Toni Ahmad
Published: March 2023

Penelitian ini bertujuan untuk mencermati iklim harmonisasi komunikasi pada sebuah organisasi yang meningkatkan optimalisasi anggota organisasi dalam bekerja. Metode penelitian menggunakan analisis data deskriptif kualitatif dengan pengumpulan data melalui observasi partisipan dan wawancara mendalam terkait teori enam dimensi iklim komunikasi menurut Pace & Faules. Objek penelitian adalah pegawai administrasi serta kepala tata usaha MAN Insan Cendekia Serpong. Hasil penelitian menunjukkan bahwa enam faktor dalam menganalisis iklim komunikasi menurut Pace dan Faules berjalan kondusif dan positif di organisasi pegawai administrasi MAN Insan Cendekia Serpong. Iklim komunikasi yang harmonis tersebut mempermudah tercapainya tujuan dalam organisasi serta meningkatkan optimalisasi pegawai dalam bekerja.
INSTAGRAM SEBAGAI MEDIA KOMUNIKASI POLITIK BAGI GENERASI MILENIAL
Authors: Indrawan Jerry , Elfrita Barzah Ruth , Simanihuruk Hermina
Published: March 2023

Perkembangan teknologi informasi dan komunikasi semakin meningkat dewasa ini. Generasi milenial menjadi kalangan yang paling terpengaruh dari perkembangan teknologi ini. Perkembangan teknologi informasi dan komunikasi tersebut ditandai juga berkembangnya jenis-jenis media, yang dikenal dengan istilah media baru. Salah satu bentuk media baru tersebut adalah media sosial. Perkembangan teknologi informasi dan komunikasi juga mempengaruhi perkembangan bentuk-bentuk komunikasi politik, dari yang biasanya dilakukan secara luring, sekarang berkembang ke ranah daring. Salah satu media sosial yang banyak digunakan dalam aktivitas-aktivitas komunikasi politik adalah Instagram. Dari hasil penelitian penulis, media sosial Instagram banyak digunakan oleh generasi milenial untuk melakukan aktivitas-aktivitas komunikasi politik. Mudahnya menggunakan media sosial jenis ini membuat generasi milenial menjadikan Instagram sebagai platform utama media sosial mereka ketika menyangkut hal-hal yang terkait dengan kegiatan-kegiatan politik. Tulisan ini akan membahas bagaimana Instagram dapat menjadi media komunikasi politik bagi generasi milenial
STRATEGI KOMUNIKASI RESIKO BENCANA BAGI UPAYA PENANGGULANGAN BENCANA DAERAH (STUDI PEMETAAN RESIKO BENCANA DI KABUPATEN BENGKULU TENGAH)
Authors: Alfarabi Alfarabi , Adhrianti Lisa
Published: March 2023

Bengkulu Tengah sebagai bagian dari Provinsi Bengkulu yang merupakan daerah di wilayah kepulauan Sumatera termasuk daerah rawan bencana dengan spesifikasi identik pada bencana alam gempa dan banjir yang kerap berulang. Penelitian ini adalah untuk mengetahui strategi komunikasi pemetaan risiko bencana yang dilakukan oleh pemerintah daerah Bengkulu Tengah. Jika dalam penelitian sebelumnya, baru sampai pada tahapan melihat upaya komunikasi bencana yang dilakukan oleh pemerintah kota Bengkulu, maka penelitian ini akan secara khusus melihat upaya pemerintah kabupaten Bengkulu Tengah yang merupakan daerah rawan bencana di Provinsi Bengkulu. Dalam penelitian ini akan mengkaji konsep data (data), information (informasi), knowledge (pengetahuan) dan wisdom (kebijakan) dari pandangan Russell Lincoln Ackoff berdasarkan metode kualitatif studi kasus instrumental tunggal. Hasil penelitian menunjukkan kajian pemetaan resiko bencana di Kabupaten Bengkulu Tengah menghasilkan data berupa identifikasi bencana spesifik, lokasi berupa desa rawan bencana serta peta yang menunjukkan jenis bencana dan lokasi rawan bencana yang mampu menghasilkan kebijakan (wisdom) dari pemerintah daerah, dalam hal ini Badan Penanggulangan Bencana Daerah (BPBD) melalui pendekatan Customer Focus yang menitikberatkan kepada masyarakat sebagai unsur utama dengan upaya sosialisasi melalui Perda no. 2 tahun 2013 tentang bangunan gedung, strategi tanggap langsung turun yang dilakukan oleh satuan tugas BPBD yang diterjukan untuk mengawasi setiap lokasi rawan bencana, serta menginformasikan pemetaan bencana melalui media surat kabar juga brosur yang dapat diambil di lokasi kantor BPBD dan Sekeretariat Pemerintah Daerah Bengkulu Tengah. BPBD juga memiliki poster yang dipasang dalam ukuran besar untuk menunjukkan titik-titik lokasi rawan bencana di Bengkulu Tengah.
"Som erfarenhetsforskare, då är man med och bestämmer i forskningsprojektet"
Authors: Hultman Lill , Sandman Fredrik , Nelson Jeanette , Åkerlund Mikael , Von Koch Lena , Tistad Malin
Published: March 2023

'As a community researcher, you get to make decisions in the research project’ – an autoethnographic study about a joint research processIn a participatory action research project, we emphasize experiences of collaboration between academic and community researchers by applying analytical autoethnography. The aim of the article is to describe the research process which involves both individual and collaborative processes, and to analyze challenges in relation to participation in the ongoing research process. We identified four themes: Start-up and initial challenges, Conditions and structural prerequisites for collaboration, Joint development of work methods and Power and role distribution. Our findings are presented in two separate analyses; a collaborative inductive analysis and an academic led theoretical analysis in which Arnstein’s ladder of participation and Fricker’s concept of epistemic injustice are utilized in order to scrutinize challenges related to different degrees of participation in the research process. The results demonstrate that shared hermeneutic resources are necessary for the mitigation of epistemic injustice and enablement of mutual learning processes, such as collective writing processes. The results also indicate that a full participation for community researchers in the entire research process was difficult to achieve, both in relation to structural resources such as allocated time, and in relation to perceptions of meaning- making aspects, for example, individual interests and contributionsin terms of knowledge.
Ny bok: Peter Beresford (2021)
Authors: Hultqvist Sara
Published: March 2023

Peter Beresford (2021) Participatory ideology – from exclusion to involvement, Bristol, Policy Press
Ny bok: Jacob Knage Rasmussen (2021)
Authors: Sköld Johanna
Published: March 2023

Jacob Knage Rasmussen (2021) ”Hvem troede de jeg var?” Når tidligere børne-hjemsbørn laeser deres journal – konflikter, håndteringsstrategier og potentialer. Institut for historie, Syddansk Universitet & Danmarks Forsorgsmuseum
Alexander G. Khitaryan. 55 years
Authors: Editorial Article
Published: March 2023

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Understanding of penetrating resistance on an inclined plate to cohesive soil using two-dimensional discrete element method
Authors: Ge Jun , Nakashima Hiroshi , Wang Xiulun
Published: March 2023

In order to know the effect of varied grousers on the reaction of soil, the reaction of soil by a plate at different angles of inclination using the two-dimensional discrete element method (DEM) has been investigated. Either the simulation or the experiment, a flat iron plate with 5 × 77 × 100 (mm) was used, and the inclination angle between the plate and the soil surface ranged from 0 to 60 degrees with 15-degree intervals. According to the result, the cohesive soil model introduced in the 2D DEM could successfully replicate the experimental results considering the effects of different inclination angles of the plate and the values of the root mean square error between the simulation and the experiment were found as 6.62, 36.60, 58.63, 60.84, and 66.25 N for inclination angles from 0 to 60 degrees in the horizontal direction. Moreover, the RMSE values of 127.91, 216.06, 75.88, 110.40, and 25.49 N were obtained for the vertical direction. Overall, a minimal discrepancy was observed between the results of DEM simulation and those of experiments in the vertical component of reaction force when the inclination angle of the plate was increased.
Data fusion approach for a digital construction logistics twin
Authors: Gehring Maximilian , Rüppel Uwe
Published: March 2023

Construction site logistics deals with the transport and storage of materials as part of the execution of a construction project. An important part of construction logistics is informing those who are involved in the project about the current status of the ordered materials. On the one hand, the missing overview of the material inventory on the construction site and incoming deliveries makes efficient daily work planning on the construction site more difficult. On the other hand, unnecessary search and travel times reduce the productive working hours of employees on the construction site. In order to provide a better overview, the information from existing data sources must be linked and visualized in an easily understandable way for all project participants. Therefore, a digital construction logistics twin is proposed in this paper. Here, the challenge lies in the creation of the digital twin. The aim of this paper is to reduce the manual entry and planning effort needed. Therefore, an approach is proposed, which uses the Building Information Model (BIM), information from the technical specifications and bill of quantities as well as catalogue data from the building materials trade. The Building Information Model comprises the three-dimensional building model, information about the building components, the construction schedule (4D BIM) and the planned storage spaces on the constructions site. The catalogue data adds relevant logistic attributes and could also enables guidelines to be checked, e.g., as part of a sustainability certification (e.g., LEED). If the suppliers’ telemetry data were integrated, end-to-end material tracking would even be possible, similar to “track-and-trace” services from parcel service providers for end customers. The provision of all this data via a Building Information Model server as a “single source of truth” increases the transparency of the construction and logistics processes for everyone involved in the project. Also, this information would, for example, favor the use of autonomous means of transport, which reduces the need for manpower for transport on the construction site.
Innate immune biology in age-related macular degeneration
Authors: Ascunce Karina , Dhodapkar Rahul M. , Huang Deven , Hafler Brian P.
Published: March 2023

Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation.
Single center experience and early outcomes of Impella 5.5
Authors: Funamoto Masaki , Kunavarapu Chandra , Kwan Michael D. , Matsuzaki Yuichi , Shah Mahek , Ono Masahiro
Published: March 2023

Background

Acute decompensated heart failure (HF) and cardiogenic shock (CS) frequently are refractory to conservative treatment and require mechanical circulatory support (MCS). We report our early clinical experience and evaluate patient outcomes with the newer generation surgical Impella 5.5.

Methods

Seventy patients that underwent Impella 5.5 implantation between October 2019 and December 2021 at a single center were enrolled in this study. Pre-operative characteristics, peri-operative clinical course information, and post-operative outcomes were retrospectively collected.

Results

Fifty-seven (81%) patients survived to discharge, and 51 (76%) patients survived at the time of the first 30 days post-discharge visit. Thirty-one patients (44%) received Impella support for a bridge to advanced surgical heart failure therapy (transplant or durable left ventricular assist device [LVAD]), 27 (39%) cases were used for a bridge to recovery/decision and 12 (17.1%) cases was used for planned perioperative support for high-risk cardiac surgery procedure.

Conclusion

Our results suggest that Impella 5.5 provides favorable survival in the management of HF and CS, particularly used for a bridge to heart transplant or LVAD. Early extubation and mobilization with high flow circulatory support allowed effective tailoring of MCS approaches from peri-operative support for high-risk cardiac surgery, bridge to recovery, and to advanced surgical heart failure therapy.
Modeling structure–activity relationships with machine learning to identify GSK3-targeted small molecules as potential COVID-19 therapeutics
Authors: Pirzada Rameez Hassan , Ahmad Bilal , Qayyum Naila , Choi Sangdun
Published: March 2023

Coronaviruses induce severe upper respiratory tract infections, which can spread to the lungs. The nucleocapsid protein (N protein) plays an important role in genome replication, transcription, and virion assembly in SARS-CoV-2, the virus causing COVID-19, and in other coronaviruses. Glycogen synthase kinase 3 (GSK3) activation phosphorylates the viral N protein. To combat COVID-19 and future coronavirus outbreaks, interference with the dependence of N protein on GSK3 may be a viable strategy. Toward this end, this study aimed to construct robust machine learning models to identify GSK3 inhibitors from Food and Drug Administration–approved and investigational drug libraries using the quantitative structure–activity relationship approach. A non-redundant dataset consisting of 495 and 3070 compounds for GSK3α and GSK3β, respectively, was acquired from the ChEMBL database. Twelve sets of molecular descriptors were used to define these inhibitors, and machine learning algorithms were selected using the LazyPredict package. Histogram-based gradient boosting and light gradient boosting machine algorithms were used to develop predictive models that were evaluated based on the root mean square error and R-squared value. Finally, the top two drugs (selinexor and ruboxistaurin) were selected for molecular dynamics simulation based on the highest predicted activity (negative log of the half-maximal inhibitory concentration, pIC50 value) to further investigate the structural stability of the protein-ligand complexes. This artificial intelligence-based virtual high-throughput screening approach is an effective strategy for accelerating drug discovery and finding novel pharmacological targets while reducing the cost and time.
Identification of copper metabolism-related subtypes and establishment of the prognostic model in ovarian cancer
Authors: Zhao Songyun , Zhang Xin , Gao Feng , Chi Hao , Zhang Jinhao , Xia Zhijia , Cheng Chao , Liu Jinhui
Published: March 2023

Background

Ovarian cancer (OC) is one of the most common and most malignant gynecological malignancies in gynecology. On the other hand, dysregulation of copper metabolism (CM) is closely associated with tumourigenesis and progression. Here, we investigated the impact of genes associated with copper metabolism (CMRGs) on the prognosis of OC, discovered various CM clusters, and built a risk model to evaluate patient prognosis, immunological features, and therapy response.

Methods

15 CMRGs affecting the prognosis of OC patients were identified in The Cancer Genome Atlas (TCGA). Consensus Clustering was used to identify two CM clusters. lasso-cox methods were used to establish the copper metabolism-related gene prognostic signature (CMRGPS) based on differentially expressed genes in the two clusters. The GSE63885 cohort was used as an external validation cohort. Expression of CM risk score-associated genes was verified by single-cell sequencing and quantitative real-time PCR (qRT-PCR). Nomograms were used to visually depict the clinical value of CMRGPS. Differences in clinical traits, immune cell infiltration, and tumor mutational load (TMB) between risk groups were also extensively examined. Tumour Immune Dysfunction and Rejection (TIDE) and Immune Phenotype Score (IPS) were used to validate whether CMRGPS could predict response to immunotherapy in OC patients.

Results

In the TCGA and GSE63885 cohorts, we identified two CM clusters that differed significantly in terms of overall survival (OS) and tumor microenvironment. We then created a CMRGPS containing 11 genes to predict overall survival and confirmed its reliable predictive power for OC patients. The expression of CM risk score-related genes was validated by qRT-PCR. Patients with OC were divided into low-risk (LR) and high-risk (HR) groups based on the median CM risk score, with better survival in the LR group. The 5-year AUC value reached 0.74. Enrichment analysis showed that the LR group was associated with tumor immune-related pathways. The results of TIDE and IPS showed a better response to immunotherapy in the LR group.

Conclusion

Our study, therefore, provides a valuable tool to further guide clinical management and tailor the treatment of patients with OC, offering new insights into individualized treatment.
Reduced order modeling of non-linear monopile dynamics via an AE-LSTM scheme
Authors: Simpson Thomas , Dervilis Nikolaos , Couturier Philippe , Maljaars Nico , Chatzi Eleni
Published: March 2023

Non-linear analysis is of increasing importance in wind energy engineering as a result of their exposure in extreme conditions and the ever-increasing size and slenderness of wind turbines. Whilst modern computing capabilities facilitate execution of complex analyses, certain applications which require multiple or real-time analyses remain a challenge, motivating adoption of accelerated computing schemes, such as reduced order modelling (ROM) methods. Soil structure interaction (SSI) simulations fall in this class of problems, with the non-linear restoring force significantly affecting the dynamic behaviour of the turbine. In this work, we propose a ROM approach to the SSI problem using a recently developed ROM methodology. We exploit a data-driven non-linear ROM methodology coupling an autoencoder with long short-term memory (LSTM) neural networks. The ROM is trained to emulate a steel monopile foundation constrained by non-linear soil and subject to forces and moments at the top of the foundation, which represent the equivalent loading of an operating turbine under wind and wave forcing. The ROM well approximates the time domain and frequency domain response of the Full Order Model (FOM) over a range of different wind and wave loading regimes, whilst reducing the computational toll by a factor of 300. We further propose an error metric for capturing isolated failure instances of the ROM.
The improvement of energy-consuming right trading policy on the efficiency of urban green development
Authors: Guo Bingnan , Hu Peiji , Zhang Hao , Weng Xiayan , Hu Feng
Published: March 2023

As a measure to promote the reform of China’s ecological civilization system, the energy-consuming right trading policy has great potential to reduce pollutant emissions and achieve green development in China. Based on the panel data of 254 cities in China from 2005 to 2019, this paper uses difference-in-differences (DID) model and super-efficiency slacks-based measure (Super-SBM) to investigate the impact of energy-consuming right trading policy on the efficiency of urban green development. The findings are as follows. i) The energy-consuming right trading policy can significantly promote the efficiency of urban green development. The conclusion still holds after a series of robustness tests. ii) The energy-consuming right trading policy can improve the efficiency of urban green development by promoting green technology innovation. This finding supports the Porter Hypothesis. iii) Heterogeneity analysis shows that the energy-consuming right trading policy can significantly improve the green development efficiency of cities in the eastern region. On the contrary, there is no significant effect on the green development efficiency of cities in the central and western regions. The government should expand the scope of energy-consuming right trading policy implementation according to local conditions. At the same time, the government should also stimulate enterprises to innovate green technologies and maximize the effect of the energyconsuming right trading policy on the efficiency of green development.