bluuebunny/crossref_metadata_2025 huggingface dataset:
Scientific and technological advances in the development of sustainable disease management tools: a case study on kiwifruit bacterial canker
Authors: Santos Miguel G. , Nunes da Silva Marta , Vasconcelos Marta W. , Carvalho Susana M. P.
Published: January 2024

Plant disease outbreaks are increasing in a world facing climate change and globalized markets, representing a serious threat to food security. Kiwifruit Bacterial Canker (KBC), caused by the bacterium Pseudomonas syringae pv. actinidiae (Psa), was selected as a case study for being an example of a pandemic disease that severely impacted crop production, leading to huge economic losses, and for the effort that has been made to control this disease. This review provides an in-depth and critical analysis on the scientific progress made for developing alternative tools for sustainable KBC management. Their status in terms of technological maturity is discussed and a set of opportunities and threats are also presented. The gradual replacement of susceptible kiwifruit cultivars, with more tolerant ones, significantly reduced KBC incidence and was a major milestone for Psa containment – which highlights the importance of plant breeding. Nonetheless, this is a very laborious process. Moreover, the potential threat of Psa evolving to more virulent biovars, or resistant lineages to existing control methods, strengthens the need of keep on exploring effective and more environmentally friendly tools for KBC management. Currently, plant elicitors and beneficial fungi and bacteria are already being used in the field with some degree of success. Precision agriculture technologies, for improving early disease detection and preventing pathogen dispersal, are also being developed and optimized. These include hyperspectral technologies and forecast models for Psa risk assessment, with the latter being slightly more advanced in terms of technological maturity. Additionally, plant protection products based on innovative formulations with molecules with antibacterial activity against Psa (e.g., essential oils, phages and antimicrobial peptides) have been validated primarily in laboratory trials and with few compounds already reaching field application. The lessons learned with this pandemic disease, and the acquired scientific and technological knowledge, can be of importance for sustainably managing other plant diseases and handling future pandemic outbreaks.
Changing discourses of Chinese language maintenance in Australia: unpacking language ideologies of first-generation Chinese immigrant parents from People’s Republic of China
Authors: Wang Yining , Li Jia
Published: January 2024

Parental agency of their children’s language learning is often determined by their perceptions of the significance of the language in both family and society levels. Based on a larger ethnography conducted in Sydney from 2017 to 2020, this study investigates the language ideologies of Chinese immigrant parents from the People’s Republic of China in the recent decades, regarding the maintenance of their children’s Chinese heritage language(s). Drawing on the concept of language as pride and profit shifting between communities across time and space, this study reveals that Chinese parents primarily emphasize the economic benefits associated with Chinese languages when it comes to preserving their heritage language(s). While the significance of cultural pride and identity remains evident, there is a notable shift where the concept of pride is merging with that of profit concerning the importance of Chinese heritage language. However, the commodification of Chinese and identity, privileging “national” mandarin while marginalizing “regional” others, impedes the transmission of diverse Chinese heritage languages other than Mandarin. Simultaneously, the value-laden calculation of language prioritizes the “most” prestigious English, often at the expense of “heritage” Mandarin, regardless of its acknowledged economic potential. The findings illustrate how language ideologies and practices within the Chinese diaspora are shaped by power conflicts between English and Mandarin Chinese, hierarchical distinctions between Mandarin and non-Mandarin Chinese, and subtle stratification within regional Chinese languages. The research underscores the challenges faced by minority communities in preserving their heritage languages, particularly those with limited economic capital or political influence.
Do extreme temperatures affect cognition? A short review of the impact of acute heat stress on cognitive performance of firefighters
Authors: Thompson Catherine , Ferrie Lucy , Pearson Stephen J. , Highlands Brian , Matthews Martyn J.
Published: January 2024

Research shows that exposure to high environmental temperatures can affect task performance. Theoretical explanations outline that heat is a source of stress that competes for limited-capacity resources, therefore if a task is resource-intensive, and/or if heat stress is extreme, performance will suffer. One occupation in which individuals complete demanding tasks and make difficult decisions, often in temperatures exceeding 200°C, is firefighting. Yet very little is currently known about the impact of heat stress on the cognitive functioning of firefighters. This short review summarizes the limited research in this area, focusing on studies that measured cognition of firefighters following a realistic training exercise. The findings are mixed with evidence that heat stress improves, impairs, and has no impact on cognitive functioning. While there are differences in the firefighting activities utilized, and the temperatures that participants were exposed to, it is argued that the varied findings can be attributed to the tasks used to assess cognitive processing, and the cognitive functions being measured. In accordance with the wider field of research, it is concluded that complex functioning, such as sustained attention, vigilance, and working memory is negatively impacted by acute exposure to extreme heat. Greater understanding of factors affecting cognition would inform safety practices and more research is needed to understand how and when heat stress may influence cognition in firefighting scenarios.
Exploring the factors influencing the intention to clothing and textiles recycling among Chinese college students’: a study based on TPB and VBN
Authors: Sun Ningna , Liu Dong , Zhang Jianrui
Published: January 2024

Recycling apparel and fabrics is essential for preserving resources and protecting the environment, providing considerable global advantages for ecology and society. This study sought to explore the participation of Chinese college students in the recycling of clothing and fabrics by combining the Theory of Planned Behavior (TPB), the Value-Belief-Norm theory (VBN), self-identity, school education, and perceived policy effectiveness to create a comprehensive model. A total of 1,027 valid samples were obtained through stratified sampling and random sampling, primarily sourced from Eastern China, and analyzed through Structural Equation Modeling (SEM) utilizing AMOS. The results of the research suggested the following: (1) College students’ biospheric values emerged as the most influential factor in predicting their inclination to participate in recycling behavior. (2) VBN (encompassing biospheric and altruistic values) and self-identity significantly contributed to shaping attitude and perceived behavioral control, which in turn impacted individuals’ intention to participate in recycling. (3) School education exerted a stronger moderating influence than perceived policy effectiveness on the relationship between attitude, perceived behavioral control, and intention. The comprehensive model proposed in this study demonstrated superior predictive capability in explaining college students’ willingness to participate in clothing and textiles recycling. It has been proven to be practical and effective. Lastly, schools should promote the practice of clothing and textiles recycling, cultivate good values, and utilize the power of social influence to encourage college students to participate in clothing and textiles recycling. The government should improve relevant laws and regulations, collaborate with academia, and adopt measures like incentives to create a pro-environment atmosphere.
A dual-factor model perspective on depressed inpatients: examining the dynamics of mental health and therapy outcomes
Authors: Brailovskaia Julia , von Brachel Ruth , van Hall Franziska , Teismann Tobias , Hirschfeld Gerrit , Margraf Jürgen
Published: January 2024

Background

The dual-factor model of mental health posits that mental health and mental illness constitute two distinct axes; accordingly the model identifies four mental health groups: (1) complete mental health, (2) troubled, (3) vulnerable, (4) symptomatic but content. Yet, only a few studies investigated effectiveness of therapy on both dimensions of mental health simultaneously. Against this background, the present study aimed to determine proportions and changes of group assignments in depressed inpatients undergoing therapy.

Method

N = 1,044 depressed inpatients (age in years: M = 53.36, SD = 9.81, range: 17–83) completed a pre- and a post-treatment survey including questionnaires on depression, anxiety, and positive mental health. A total of n = 328 persons completed the survey also at 6-month and 12-month follow-up assessments.

Results

In the classification that included depression symptoms and positive mental health, 49% of the participants were classified as troubled and 13.2% were classified as completely mentally healthy at the pre-treatment assessment. At the post-treatment, 9.5% were classified as troubled and 55.7% were classified as completely mentally healthy. In the classification that included anxiety symptoms and positive mental health, 21.9% of the participants were classified as troubled and 14.2% were classified as completely mentally healthy at the pre-treatment assessment. At the post-treatment, 3.7% were classified as troubled and 56.1% were classified as completely mentally healthy. About 10 to 20% of patients showed an improvement in depression/anxiety and positive mental health, whereas another 10 to 20% showed a reduction in depression/anxiety, but only a minor increase in positive mental health between pre- and post-treatment.

Conclusion

Findings are in line with past research inspired by the dual-factor model in showing that enhancing positive mental health and alleviating psychopathology do not always co-occur in treatment. It is therefore important to implement measures of both psychopathology and positive mental health in therapy outcome studies, and to promote interventions targeting both psychopathology and positive mental health.
Students' mental health during the pandemic: results of the observational cross-sectional COVID-19 MEntal health inTernational for university Students (COMET-S) study
Authors: Fountoulakis Konstantinos N. , Alias Nor Aziah , Bjedov Sarah , Fountoulakis Nikolaos K. , Gonda Xenia , Hilbig Jan , Jakovljević Miro , Kulig Barbara , Mahale Girija , Manafis Alexandros , Mohammed Muftau , Nadareishvili Ilia , Navickas Alvydas , Patsali Mikaella E. , Pavlichenko Alexey , Pilaga Sindija Mairita , Razali Salmi , Romanov Dmitry , Rossitza Iakimova , Salihu Auwal Sani , Sinauridze Ana , Stoyanova Maria , Thosar Ketaki , Vorobjova Julija , Vrublevska Jelena , Rancans Elmars , Javed Afzal , Theodorakis Pavlos N. , Breda Joao , Smirnova Daria
Published: January 2024

Introduction

The aim of the study was to search rates of depression and mental health in university students, during the COVID-19 pandemic.

Materials and methods

This is an observational cross-sectional study. A protocol gathering sociodemographic variables as well as depression, anxiety and suicidality and conspiracism was assembled, and data were collected anonymously and online from April 2020 through March 2021. The sample included 12,488 subjects from 11 countries, of whom 9,026 were females (72.2%; aged 21.11 ± 2.53), 3,329 males (26.65%; aged 21.61 ± 2.81) and 133 “non-binary gender” (1.06%; aged 21.02 ± 2.98). The analysis included chi-square tests, correlation analysis, ANCOVA, multiple forward stepwise linear regression analysis and Relative Risk ratios.

Results

Dysphoria was present in 15.66% and probable depression in 25.81% of the total study sample. More than half reported increase in anxiety and depression and 6.34% in suicidality, while lifestyle changes were significant. The model developed explained 18.4% of the development of depression. Believing in conspiracy theories manifested a complex effect. Close to 25% was believing that the vaccines include a chip and almost 40% suggested that facemask wearing could be a method of socio-political control. Conspiracism was related to current depression but not to history of mental disorders.

Discussion

The current study reports that students are at high risk for depression during the COVID-19 pandemic and identified specific risk factors. It also suggested a role of believing in conspiracy theories. Further research is important, as it is targeted intervention in students' groups that are vulnerable both concerning mental health and conspiracism.
Mental health and Multiracial/ethnic adults in the United States: a mixed methods participatory action investigation
Authors: Shaff Jaimie , Wang Xinzi , Cubbage Janel , Bandara Sachini , Wilcox Holly C.
Published: January 2024

Introduction

Addressing gaps in the integration of justice, diversity, equity, and inclusion (J-DEI) in public health research and practice, this study investigates the mental health of Multiracial and multiethnic adults in the United States (U.S.). A rapidly growing racial/ethnic group in the U.S., Multiracial and multiethnic populations are often excluded or underrepresented in standard public health research and practice, and little is known about their mental health or associated risk and protective factors.

Methods

To investigate this knowledge gap, an electronic cross-sectional survey was conducted in two waves in 2022, pulling from various community sources, with 1,359 respondents in total. Complementing this, seventeen semi-structured interviews were performed with a subset of survey participants. Data were analyzed using a mix of statistical methods and staged hybrid inductive-deductive thematic analysis.

Results

Findings indicate over half of the participants endorsed at least one mental health concern with prevalence of anxiety, depression, post-traumatic stress disorder, and suicidal thoughts and behaviors surpassing available national estimates. Exposure to trauma, discrimination, and microaggressions were found to play a significant role in these outcomes. Conversely, strong social support and strong ethnic identity emerged as protective factors. Qualitative insights brought forward the challenges faced by individuals in navigating bias and stigma, especially in the context of mental health care. Despite these barriers, emerging themes highlighted resilience, the importance of secure identity formation, and the critical role of community and cultural support.

Conclusions

The marked prevalence of mental health concerns among Multiracial and multiethnic populations emphasizes the pressing need for tailored interventions and inclusive research methodologies. Recognizing and addressing the unique challenges faced by these communities is imperative in driving mental health equity in the U.S. The findings advocate for community-engaged practices, interdisciplinary collaborations, and the importance of addressing mental health challenges with cultural sensitivity, particularly in historically oppressed and marginalized groups. Future efforts must focus on refining these practices, ensuring that public health initiatives are genuinely inclusive and equitable.
The relationship between individual-level socioeconomic status and preference for medical service in primary health institutions: a cross-sectional study in Jiangsu, China
Authors: Miao Chunxia , Fang Xin , Sun Hong , Yin Yani , Li Bo , Shen Wenxing , Chen Jie , Huang Xiaojing
Published: January 2024

Background

While China's primary health care (PHC) system covers all citizens, the use of medical services supplied by primary health institutions (PHIs) is not at ideal levels. This study explored the impact of socioeconomic status (SES) on residents' first choice of medical services provided by PHIs.

Methods

This community-based, cross-sectional study was conducted in Jiangsu Province, China, from October 2021 to March 2022. A custom-designed questionnaire was used to evaluate 4,257 adults, of whom 1,417 chose to visit a doctor when they were sick. Logistic regression was used to test the relationships among SES, other variables and the choice of medical services, and interaction effects were explored.

Results

A total of 1,417 subjects were included in this study (48.7% female; mean age 44.41 ± 17.1 years). The results showed that older age (p < 0.01), rural residence (p < 0.01), a preference for part-time medical experts in PHIs (p < 0.01), and lack of coverage by basic medical insurance (p < 0.05) were associated with the first choice to use PHIs. In the multiple logistic regression model, SES was not associated with the first choice of medical services supplied by PHIs (p > 0.05), but it interacted with three variables from the Commission on Social Determinants of Health Framework (material circumstances, behaviors and biological factors, and psychosocial factors).

Conclusion

Vulnerable individuals who are the target visitors to PHIs are older, live in rural areas, and suffer from chronic diseases. SES, as a single factor, did not impact whether medical services at PHIs were preferred, but it mediated relationships with other factors.
Health damage assessment of commuters and staff in the metro system based on field monitoring—A case study of Nanjing
Authors: Su Shu , Li Shuhao , Ding Yujie , Mao Peng , Chong Dan
Published: January 2024

Introduction

The metro has emerged as a major mode of transportation. A significant number of commuters and staff in the metro system are exposed to air pollutants because of its shielded environment, and substantial health damage requires quantitative assessment. Previous studies have focused on comparing the health impacts among different transportation modes, overlooking the specific population characteristics and pollutant distribution in metro systems.

Methods

To make improvements, this study implements field monitoring of the metro's air environment utilizing specialized instruments and develops a health damage assessment model. The model quantifies health damage of two main groups (commuters and staff) in metro systems at three different areas (station halls, platforms, and metro cabins) due to particulate matter 10 and benzene series pollution.

Conclusion

A case study of Nanjing Metro Line 3 was conducted to demonstrate the applicability of the model. Health damage at different metro stations was analyzed, and the health damage of commuters and staff was assessed and compared. This study contributes to enhancing research on health damage in the metro systems by providing a reference for mitigation measures and guiding health subsidy policies.
Knowledge, attitudes, and practices of patients with recurrent pregnancy loss toward pregnancy loss
Authors: Mu Fangxiang , He Tianyu , Wang Kexin , Wang Fang
Published: January 2024

Objective

Self-management is crucial in managing recurrent pregnancy loss (RPL). This study explored the knowledge, attitudes, and practices (KAP) of patients with RPL toward RPL.

Methods

This cross-sectional study was conducted among patients with RPL between January 2023 and June 2023 at the Second Hospital of Lanzhou University. Participants’ demographic characteristics and KAP were determined using a self-designed questionnaire (Cronbach’s α = 0.818). Structural equation modeling (SEM) was used to observe the correlations among KAP and different factors.

Results

This study analyzed 497 valid questionnaires. The mean knowledge, attitude, and practice scores were 11.59 ± 4.30 (possible range: 0–20, 57.95%), 44.17 ± 3.18 (possible range: 13–65, 67.95%), and 32.39 ± 5.22 (possible range: 8–40, 80.98%), indicating poor knowledge, moderate attitude, and proactive practice. Age was non-linearly associated with the KAP dimensions, with a positive impact of age on KAP among those aged <32 years old. Knowledge was directly influenced by education (β = 1.49, p < 0.001) and income (β = 1.08, p < 0.001). The attitude was directly influenced by knowledge (β = 0.25, p < 0.001) and indirectly influenced by education (β = 0.37, p = 0.001) and income (β = 0.27, p < 0.001). Practice was directly influenced by knowledge (β = 0.26, p < 0.001), attitude (β = 0.28, p < 0.001), and income (β = 0.68, p = 0.012), and indirectly influenced by knowledge (β = 0.07, p = 0.001), education (β = 0.59, p = 0.001), and income (β = 0.42, p < 0.001).

Conclusion

Women with RPL in Lanzhou show poor knowledge, moderate attitude, and proactive practice toward RPL. This study identified specific KAP items that would require improvements. The study also identified categories of patients who would need more attention.
Epidemiological characteristics and prediction model construction of hemorrhagic fever with renal syndrome in Quzhou City, China, 2005–2022
Authors: Gao Qing , Wang Shuangqing , Wang Qi , Cao Guoping , Fang Chunfu , Zhan Bingdong
Published: January 2024

Background

Hemorrhagic fever with renal syndrome (HFRS) is one of the 10 major infectious diseases that jeopardize human health and is distributed in more than 30 countries around the world. China is the country with the highest number of reported HFRS cases worldwide, accounting for 90% of global cases. The incidence level of HFRS in Quzhou is at the forefront of Zhejiang Province, and there is no specific treatment for it yet. Therefore, it is crucial to grasp the epidemiological characteristics of HFRS in Quzhou and establish a prediction model for HFRS to lay the foundation for early warning of HFRS.

Methods

Descriptive epidemiological methods were used to analyze the epidemic characteristics of HFRS, the incidence map was drawn by ArcGIS software, the Seasonal AutoRegressive Integrated Moving Average (SARIMA) and Prophet model were established by R software. Then, root mean square error (RMSE) and mean absolute error (MAE) were used to evaluate the fitting and prediction performances of the model.

Results

A total of 843 HFRS cases were reported in Quzhou City from 2005 to 2022, with the highest annual incidence rate in 2007 (3.93/100,000) and the lowest in 2022 (1.05/100,000) (P trend<0.001). The incidence is distributed in a seasonal double-peak distribution, with the first peak from October to January and the second peak from May to July. The incidence rate in males (2.87/100,000) was significantly higher than in females (1.32/100,000). Farmers had the highest number of cases, accounting for 79.95% of the total number of cases. The incidence is high in the northwest of Quzhou City, with cases concentrated on cultivated land and artificial land. The RMSE and MAE values of the Prophet model are smaller than those of the SARIMA (1,0,1) (2,1,0)12 model.

Conclusion

From 2005 to 2022, the incidence of HFRS in Quzhou City showed an overall downward trend, but the epidemic in high-incidence areas was still serious. In the future, the dynamics of HFRS outbreaks and host animal surveillance should be continuously strengthened in combination with the Prophet model. During the peak season, HFRS vaccination and health education are promoted with farmers as the key groups.
Toward adapting the UN’s healthy aging agenda for India: tailoring to unique historical context and traditions
Authors: Sastry Nandakumar Bidare , Vempadapu Monika , Sivananjiah Shalini
Published: January 2024

India is known for its rich cultural heritage with different cultures and customs. Indian historical traditions and cultures were molded in a manner that most older adults were cared for at home by their children. However, India is being urbanized and developing swiftly changing its socio-cultural scenarios. With globalization and the increased popularity of social media, the youth is more ambitious than ever and is ready to migrate and explore. Fueled by the rapid aging of the global population, demand is escalating for robust programs, policies, and activities to improve the lives of older adults. However, most of these schemes have not yet been fully implemented nationwide; several state governments have yet to realize their full potential due to the lack of resources and competing priorities. Aligning with the UN’s healthy aging agenda, several programs and policies in India are contributing toward ensuring quality aged care services. This paper explores the challenges and opportunities for effective ground-level translation from precepts to practice.
Anxious and depressive symptoms mediate the influence of sleep quality on suicidality in young adults
Authors: Slanitz Corinna , Fuchshuber Jürgen , Fink Andreas , Unterrainer Human-Friedrich
Published: January 2024

This study investigated how sleep quality affects the global severity of psychiatric symptoms, including suicidality, in young adults. Poor sleep quality has a significant impact on mental health and should therefore be given special attention in suicidal treatment. 1,214 participants (914 females; age: M = 25.81, SD = 6.35) completed the Brief Symptom Inventory (BSI-18), the Scale for Suicidal Experience and Behavior (SSEV), and the Pittsburgh Sleep Quality Index (PSQI) via an online survey. Correlation statistics and path analysis were conducted for data evaluation. Thereby, anxiety and depression but not somatization mediated the relationship between sleep quality and suicidality. Our findings confirm the putative link between diminished sleep quality and increased suicidality and may lead to an early detection of suicidal behavior.
Development of an epigenetic clock to predict visual age progression of human skin
Authors: Bienkowska Agata , Raddatz Günter , Söhle Jörn , Kristof Boris , Völzke Henry , Gallinat Stefan , Lyko Frank , Kaderali Lars , Winnefeld Marc , Grönniger Elke , Falckenhayn Cassandra
Published: January 2024

Aging is a complex process characterized by the gradual decline of physiological functions, leading to increased vulnerability to age-related diseases and reduced quality of life. Alterations in DNA methylation (DNAm) patterns have emerged as a fundamental characteristic of aged human skin, closely linked to the development of the well-known skin aging phenotype. These changes have been correlated with dysregulated gene expression and impaired tissue functionality. In particular, the skin, with its visible manifestations of aging, provides a unique model to study the aging process. Despite the importance of epigenetic age clocks in estimating biological age based on the correlation between methylation patterns and chronological age, a second-generation epigenetic age clock, which correlates DNAm patterns with a particular phenotype, specifically tailored to skin tissue is still lacking. In light of this gap, we aimed to develop a novel second-generation epigenetic age clock explicitly designed for skin tissue to facilitate a deeper understanding of the factors contributing to individual variations in age progression. To achieve this, we used methylation patterns from more than 370 female volunteers and developed the first skin-specific second-generation epigenetic age clock that accurately predicts the skin aging phenotype represented by wrinkle grade, visual facial age, and visual age progression, respectively. We then validated the performance of our clocks on independent datasets and demonstrated their broad applicability. In addition, we integrated gene expression and methylation data from independent studies to identify potential pathways contributing to skin age progression. Our results demonstrate that our epigenetic age clock, VisAgeX, specifically predicting visual age progression, not only captures known biological pathways associated with skin aging, but also adds novel pathways associated with skin aging.
Construction and validation of a method for automated time label segmentation of heart sounds
Authors: Li Liuying , Huang Min , Dao Ling , Feng Xixi , Liu Yifeng , Wei Changyou , Liu Fangfang , Zhang Jing , Xu Fan
Published: January 2024

Heart sound detection technology plays an important role in the prediction of cardiovascular disease, but the most significant heart sounds are fleeting and may be imperceptible. Hence, obtaining heart sound information in an efficient and accurate manner will be helpful for the prediction and diagnosis of heart disease. To obtain heart sound information, we designed an audio data analysis tool to segment the heart sounds from single heart cycle, and validated the heart rate using a finger oxygen meter. The results from our validated technique could be used to realize heart sound segmentation. Our robust algorithmic platform was able to segment the heart sounds, which could then be compared in terms of their difference from the background. A combination of an electronic stethoscope and artificial intelligence technology was used for the digital collection of heart sounds and the intelligent identification of the first (S1) and second (S2) heart sounds. Our approach can provide an objective basis for the auscultation of heart sounds and visual display of heart sounds and murmurs.
Artificial intelligence in healthcare: combining deep learning and Bayesian optimization to forecast COVID-19 confirmed cases
Authors: Alhhazmi Areej , Alferidi Ahmad , Almutawif Yahya A. , Makhdoom Hatim , Albasri Hibah M. , Sami Ben Slama
Published: January 2024

Healthcare is a topic of significant concern within the academic and business sectors. The COVID-19 pandemic has had a considerable effect on the health of people worldwide. The rapid increase in cases adversely affects a nation's economy, public health, and residents' social and personal well-being. Improving the precision of COVID-19 infection forecasts can aid in making informed decisions regarding interventions, given the pandemic's harmful impact on numerous aspects of human life, such as health and the economy. This study aims to predict the number of confirmed COVID-19 cases in Saudi Arabia using Bayesian optimization (BOA) and deep learning (DL) methods. Two methods were assessed for their efficacy in predicting the occurrence of positive cases of COVID-19. The research employed data from confirmed COVID-19 cases in Saudi Arabia (SA), the United Kingdom (UK), and Tunisia (TU) from 2020 to 2021. The findings from the BOA model indicate that accurately predicting the number of COVID-19 positive cases is difficult due to the BOA projections needing to align with the assumptions. Thus, a DL approach was utilized to enhance the precision of COVID-19 positive case prediction in South Africa. The DQN model performed better than the BOA model when assessing RMSE and MAPE values. The model operates on a local server infrastructure, where the trained policy is transmitted solely to DQN. DQN formulated a reward function to amplify the efficiency of the DQN algorithm. By examining the rate of change and duration of sleep in the test data, this function can enhance the DQN model's training. Based on simulation findings, it can decrease the DQN work cycle by roughly 28% and diminish data overhead by more than 50% on average.
Simultaneous localization and mapping in a multi-robot system in a dynamic environment with unknown initial correspondence
Authors: Malakouti-Khah Hadiseh , Sadeghzadeh-Nokhodberiz Nargess , Montazeri Allahyar
Published: January 2024

A basic assumption in most approaches to simultaneous localization and mapping (SLAM) is the static nature of the environment. In recent years, some research has been devoted to the field of SLAM in dynamic environments. However, most of the studies conducted in this field have implemented SLAM by removing and filtering the moving landmarks. Moreover, the use of several robots in large, complex, and dynamic environments can significantly improve performance on the localization and mapping task, which has attracted many researchers to this problem more recently. In multi-robot SLAM, the robots can cooperate in a decentralized manner without the need for a central processing center to obtain their positions and a more precise map of the environment. In this article, a new decentralized approach is presented for multi-robot SLAM problems in dynamic environments with unknown initial correspondence. The proposed method applies a modified Fast-SLAM method, which implements SLAM in a decentralized manner by considering moving landmarks in the environment. Due to the unknown initial correspondence of the robots, a geographical approach is embedded in the proposed algorithm to align and merge their maps. Data association is also embedded in the algorithm; this is performed using the measurement predictions in the SLAM process of each robot. Finally, simulation results are provided to demonstrate the performance of the proposed method.
The effect of attending rehabilitation after traumatic knee joint injury on femoral articular cartilage morphology in collegiate rugby players with a history of intracapsular knee joint injury during two-year consecutive rugby seasons
Authors: Hori Miyuki , Terada Masafumi , Suga Tadashi , Isaka Tadao
Published: January 2024

Introduction

This present study aimed to compare ultrasonographic measures of femoral articular cartilage during two-year seasons between collegiate rugby players who have attended supervised rehabilitation following intracapsular knee joint injury and those without a history of knee injury.

Methods

Using a prospective observational study design, 12 male collegiate rugby players with a previous history of intracapsular knee joint injury who have received and completed supervised rehabilitation following their injury and 44 players without knee joint injury participated in this study. Ultrasonographic images were used to verify changes in femoral articular cartilage thickness and cross-sectional area (CSA) with or without a previous history of knee joint injury over two consecutive rugby seasons.

Results

Significant time main effects were observed for the lateral condylar thickness (p < 0.001), the intercondylar thickness (p = 0.001), the medial condylar thickness (p < 0.001), and CSA (p < 0.001). No significant interactions nor group main effects were identified for all femoral articular cartilage (p < 0.05).

Conclusions

Collegiate rugby players demonstrated a decrease in femoral articular cartilage thickness and CSA over two-year consecutive rugby seasons. These findings indicate that engaging in collegiate rugby induces alterations in femoral articular cartilage structure. Furthermore, there were no differences in all femoral cartilage outcome measures between rugby players with and without a previous history of traumatic knee joint injury. Therefore, attending supervised rehabilitation at the time of their knee joint injury appeared to reduce the impact of a previous history of intracapsular knee joint injury on the change in femoral articular cartilage thickness and CSA among active rugby players.
Case Report: “Aggressive” perioperative antiseizure medication prophylaxis in patients with glioma-related epilepsy at high risk of early postoperative seizures following awake craniotomy
Authors: Freund Brin E. , Jaeckle Kurt , Quinones-Hinojosa Alfredo , Feyissa Anteneh M.
Published: January 2024

Early postoperative seizures (EPS) are a common complication of brain tumor surgery. EPS can lead to hemorrhage, cerebral hypoxia, increased intracranial pressure, longer hospitalization, reduced quality of life, decreased overall survival, and increased morbidity. However, there are no formal guidelines on perioperative antiseizure medication (ASM) management in patients with tumor-related epilepsy who are deemed high risk for EPS. In this study, we describe the case of a 38-year-old man with isocitrate dehydrogenase-mutant mixed glioma and two episodes of EPS manifesting with status epilepticus during prior tumor surgeries and who presented with tumor progression. The Tumor Board recommended awake craniotomy with direct electrical stimulation (DES). The patient was administered aggressive preoperative “prophylactic” ASMs by increasing the maintenance doses of lacosamide and levetiracetam by 25% 48 h before surgery. An intravenous load of fosphenytoin (20 mg/kg) was administered in the operating room before DES, followed by a maintenance dosing of 300 mg/day for 14 days. EPS did not occur, and he was discharged home on postoperative day 4. Our case illustrates that aggressive perioperative prophylactic ASM therapy beyond the maintenance ASM regimen can be considered in patients with tumor-related epilepsy at risk of EPS.
Short-term outcomes of robotic vs. laparoscopic surgery for rectal cancer after neoadjuvant therapy: a meta-analysis
Authors: Zhang Yuqiang , Dong Bo , Li Guanglin , Ye Wei
Published: January 2024

Background

The effect of robotic surgery (RS) for rectal cancer after neoadjuvant therapy is still controversial, and a comprehensive search and analysis of the current relevant evidence is necessary. Our study aimed to evaluate the efficacy of RS for rectal cancer after neoadjuvant therapy compared with conventional laparoscopic surgery (LS).

Methods

Up to August 23, 2023, Embase, PubMed, Web of Science, and Cochrane databases were searched for studies of RS for rectal cancer after neoadjuvant therapy. Odds ratio (OR) or mean difference (MD) was used to calculate the effect sizes using RevMan 5.3.

Results

A total of 12 studies reporting on 11,686 participants were included. Compared with LS, RS increased the operative time (MD 35.16 min; 95% CI: 16.24, 54.07), but it did significantly reduce the risk of the conversion to open surgery (OR 0.46, 95% CI 0.40, 0.53) and improved the TME incomplete rate (OR 0.40, 95% CI 0.17, 0.93). Moreover, there were no difference in total postoperative complications (OR 1.13, 95% CI 0.84, 1.52), circumferential resection margin positivity (OR 0.90, 95% CI 0.63, 1.27), distal margin positive (OR 0.60, 95% CI 0.29, 1.22), blood loss (MD −11.57 ml; 95% CI: −39.09, 15.94), length of hospital stay (MD −0.08 days; 95% CI: −1.26, 1.10), mortality (OR 0.59, 95% CI 0.29, 1.21), lymph node harvested (MD 0.69.; 95% CI: −0.43, 1.82), and the time of first flatus (MD −0.47 days; 95% CI: −1.19, 0.25) between the two groups.

Conclusions

RS was associated with superiority over LS in reducing the risk of the conversion to open surgery and improving TME incomplete rate, which suggested that RS could be an effective method for treating rectal cancer after neoadjuvant therapy.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=460084, PROSPERO (CRD42023460084).
Case report: Intraneural perineurioma in dogs: a case series and brief literature review
Authors: Yin Ji-Hang , Sexton Brittani , Jukier Tom , Yanke Amy B. , Holland Merrilee , Miller Andrew D. , Stranahan Lauren , Hoffmann Aline Rodrigues , Sandey Maninder
Published: January 2024

Intraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural perineurioma frequently affects adult dogs aged between 3 and 10 years old, with a male predominance. Clinical signs associated with intraneural perineurioma in dogs include spinal pain, lameness, and paresis, resulting from the involvement of spinal nerve roots of the pelvic limbs, brachial plexus, or distal part of the median nerve. Most neoplasms had characteristic pseudo-onion bulb patterns on histopathology. Neoplastic perineurial cells, in most cases, expressed laminin and claudin-1, and NF200 consistently highlighted the central axon. While the immunohistochemical (IHC) profile of intraneural perineurioma in veterinary medicine remains incompletely characterized, the available IHC data from all reported cases suggest that a combination of laminin and claudin-1 immunomarkers, along with distinctive histological features, can assist in establishing a definitive diagnosis of intraneural perineurioma.
Outcomes in dogs undergoing surgical stabilization and non-stereotactic radiation therapy for axial and appendicular bone tumors
Authors: Griffin Maureen A. , Mastorakis Andrea , Wustefeld-Janssens Brandan , Martin Tiffany Wormhoudt , Duda Lili , Seguin Bernard , Tremolada Giovanni
Published: January 2024

Background

Information on dogs that undergo radiation therapy (RT) with non-stereotactic protocols in addition to surgical stabilization with implant placement for treatment of bone tumors is limited.

Objective

Our primary objectives were to describe the clinical characteristics as well as short- and long-term outcomes, including complications, function, and disease progression, in dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor.

Methods

A bi-institutional retrospective case series was performed.

Animals

Eight client-owned dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor were included.

Results

Tumor types included osteosarcoma or suspected osteosarcoma (5), plasma cell tumor (2), and grade 3 fibrosarcoma (1). Radiation protocols were hypofractionated (palliative intent) in 5 dogs and fractionated (definitive intent) in 3 dogs. Five dogs experienced complications following both RT and surgery, including grade 1 complications in two dogs, a grade 2 complication in one dog, both grade 1 and 2 complications in one dog, and both grade 2 and 3 complications in one dog. Clinical signs subjectively improved in all dogs that had outcomes relative to function documented post-surgery/RT (7). Of these 7 dogs, 4 maintained long-term improvement in function and clinical signs, whereas 3 experienced subsequent recurrence/progression of clinical signs at a median of 133 days (range 91-186) postoperatively in association with biomechanical complications (screw loosening), surgical site infection, and local disease progression in 1 dog each; subsequent treatment resulted in improved clinical signs for each of these 3 dogs, such that overall good long-term functional outcomes were experienced. No dogs required amputation or additional vertebral surgery as salvage for local disease control or palliation. The median progression free interval was 206 days (range 25-1078), and the median survival time was 253 days (range 122-1078) with 1 additional dog lost to follow-up at 575 days. Two dogs experienced local disease progression, and 6 dogs experienced systemic disease progression; both dogs that developed local disease progression received palliative intent RT protocols.

Clinical relevance

In this cohort, dogs with primary bone tumors that underwent surgical stabilization with implant placement and hypofractionated or fractionated non-stereotactic RT for local treatment had a low incidence of major complications, good limb function and ambulation post-treatment, and relatively prolonged survival times despite disease progression.
Feeding spray-dried plasma to broilers early in life improved their intestinal development, immunity and performance irrespective of mycotoxins in feed
Authors: Gómez-Verduzco Gabriela , Arce-Menocal José , López-Coello Carlos , Avila-González Ernesto , Márquez-Mota Claudia C. , Polo Javier , Rangel Luis
Published: January 2024

Introduction

Fungi that produce mycotoxins can grow on certain food products, such as grains and feed, and can cause a variety of health issues if consumed by animals, including chickens. The use of spray-dried plasma (SDP) is one strategy for combating the health problems caused by mycotoxins.

Materials and methods

In the present study, Ross 308 chickens (n = 960) were divided into four treatment groups. T1 group was given a control diet (corn–soybean meal), T2 group was given a control diet +2% SDP, T3 group was given a control diet +2% SDP + mixture mycotoxins and T4 group was givena control diet + mycotoxin mixture.

Results

The presence of SDP resulted in weight gain and decreased feed efficiency, whereas mycotoxins resulted in weight loss and increased feed efficiency. SDP increased the thymus’ relative weight. The presence of mycotoxins increased the heterophile/lymphocyte ratio. The presence of mycotoxins reduced the production of IL-2 and macrophage inflammatory protein-3 Alpha (MIP-3a), whereas the presence of SDP increased the production of macrophage colony-stimulating Factor (M-CSF). SDP resulted in higher IgA concentrations in the intestinal and tracheal washes than mycotoxin. Finally, adding SDP to broiler diets boosts weight gain, feed efficiency, and immune system development.

Discussion

Our results provide information supporting that SDP is a promising tool for improving poultry immunity and performance.
Transient suppression of Wnt signaling in poor-quality buffalo oocytes improves their developmental competence
Authors: Ahuja Kriti , Batra Vipul , Kumar Rakesh , Datta Tirtha Kumar
Published: January 2024

Introduction

One of the most evolutionary conserved communication systems, the Wnt signaling pathway is a major gene regulatory pathway that affects the developmental competence of oocytes and regulates most embryonic developmental processes. The present study was undertaken to modulate the canonical Wnt (Wingless/integration) signaling pathway in the poor-quality (colorless cytoplasm after Brilliant Cresyl Blue staining, BCB-) buffalo cumulus-oocyte complexes (COCs) to improve their in vitro maturation (IVM) and embryo production (IVEP) rates.

Methods

The expression of key Wnt pathway genes was initially assessed in the good (blue cytoplasm after Brilliant Cresyl Blue staining, BCB+) and poor quality (BCB-) buffalo COCs to establish a differential activity of the Wnt pathway. The BCB- COCs were supplemented with the Wnt pathway inhibitor, Dickkopf-related protein 1 (DKK1) and later subjected to IVM and IVEP along with the BCB+ and BCB- controls. The cumulus expansion index (CEI), rate of nuclear maturation (mean percentage of oocytes in the MII stage) and embryo production, and the expression of developmentally important genes were evaluated to assess the effect of Wnt pathway inhibition on the development competence of these poor-quality oocytes.

Results

The Wnt pathway genes exhibited a significantly higher expression (p < 0.05) in the poor-quality BCB- oocytes compared to the good-quality BCB+ oocytes during the early maturation stages. The supplementation of BCB- COCs with 100 ng/mL DKK1 effectively inhibited the expression of the key mediators of the Wnt pathway (β-catenin and dishevelled homolog 1, DVL1). DKK1 supplemented BCB- COCs exhibited significantly improved cytoplasmic and nuclear maturation indices, development rates and significantly elevated expression (p < 0.05) of genes implicated in germinal vesicle breakdown (GVBD) and embryonic genome activation (EGA) vis-à-vis BCB- control COCs.

Conclusion

These data indicate that inhibition of the Wnt pathway during the initial course of oocyte maturation can improve the development competence of poor-quality buffalo oocytes.