bluuebunny/crossref_metadata_2025 huggingface dataset:
A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development
Authors: Helker Christian S. M. , Mullapudi Sri-Teja , Mueller Laura M. , Preussner Jens , Tunaru Sorin , Skog Oskar , Kwon Hyouk-Bum , Kreuder Florian , Lancman Joseph J. , Bonnavion Remy , Dong P. Duc Si , Looso Mario , Offermanns Stefan , Korsgren Ole , Spagnoli Francesca M. , Stainier Didier Y. R.
Published: May 2019

An early step in pancreas development is marked by the expression of the transcription factor Pdx1 within the pancreatic endoderm, where it is required for the specification of all endocrine cell types. Subsequently, Pdx1 expression becomes restricted to the β-cell lineage, where it plays a central role in β-cell function. This pivotal role of Pdx1 at various stages of pancreas development makes it an attractive target to enhance pancreatic β-cell differentiation and increase β-cell function. In this study, we used a newly generated zebrafish reporter to screen over 8000 small molecules for modulators of pdx1 expression. We found four hit compounds and validated their efficacy at different stages of pancreas development. Notably, valproic acid treatment increased pancreatic endoderm formation, while inhibition of TGFβ signaling led to α-cell to β-cell transdifferentiation. HC toxin, another HDAC inhibitor, enhances β-cell function in primary mouse and human islets. Thus, using a whole organism screening strategy, this study identified new pdx1 expression modulators that can be used to influence different steps in pancreas and β-cell development.
Differential diagnosis of benign and malignant vertebral compression fractures using conventional and advanced MRI techniques
Authors: Romeo Valeria , Ugga Lorenzo , Stanzione Arnaldo , Cocozza Sirio , Cuocolo Renato , Brunetti Arturo
Published: May 2019

Atraumatic vertebral compression fractures (VCFs) are commonly encountered in clinical practice and often represent a diagnostic challenge. MRI plays a major role in the differential diagnosis of benign and malignant VCFs, due to its high contrast resolution and the possibility to obtain quantitative and functional data with the employment of advanced sequences. Computer-aided diagnosis systems are also applied on MRI images for this purpose, showing promising results. In this setting, aim of this pictorial review is to elucidate the role of MRI in the differential diagnosis of VCFs with a specific focus on advanced and post-processing imaging techniques.
Human respiratory syncytial virus methyl transferase: a potential antiviral target?
Authors: Kalkeri Raj , Bhisetti Govinda , Mani Nagraj
Published: May 2019

Human respiratory syncytial virus (HRSV) causes bronchiolitis and pneumonia. The role of methyltransferase (MTase) activity of HRSV polymerase in viral replication is unknown. Literature reviews of similar viral MTases and homology- modeling of RSV MTase bound to GTP and S-adenosylmethionine (SAM) have shown sequence similarity and the conserved catalytic residues (K-D-K-E) and the SAM-binding (GXGXG) domain. Combined with the recent reports of the importance of 2’O methylation of viral RNAs in the host innate immune response evasion, and its proposed role in viral replication, HRSV MTase holds promise as a potential antiviral target. Further biological validation of HRSV MTase could facilitate the discovery of novel HRSV antivirals targeting MTase enzyme activity.
Making a Difference: Two Case Studies Describing the Impact of a Capstone Leadership Education Experience provided through a National Youth Leadership Training Program
Authors: Rosser Manda , Stedman Nicole LP , Elbert Chanda , Rutherford Tracy
Published: May 2019

Many youth leadership organizations exist today and provide a variety of leadership experiences. One such organization provides a week long leadership experience to high school students with its primary purpose being to guide students through a process of identifying a community need and developing a plan to address that need. This article reports on two qualitative case studies which investigate this leadership education tool and its impacts on the students’ involved, as well as the participating communities. The Living to Serve plans (LTS), the capstone leadership education experience, which the students develop are used to help students understand the process of identifying problems and solving those problems through identified steps.
Toward Computing the Margin of Victory in Single Transferable Vote Elections
Authors: Blom Michelle , Stuckey Peter J. , Teague Vanessa J.
Published: May 2019

The single transferable vote (STV) is a system of preferential voting for multiseat elections. Each ballot cast by a voter is a (potentially partial) ranking over a set of candidates. No techniques currently exist for computing the margin of victory (MOV) in STV elections. The MOV is the smallest number of ballot manipulations (changes, additions, and deletions) required to bring about a change in the set of elected candidates. Knowing the MOV gives insight into how much time and money should be spent on auditing the election, and whether uncovered mistakes (such as ballot box losses) throw the election result into doubt—requiring a costly repeat election—or can be safely ignored. We present algorithms for computing lower and upper bounds on the MOV in STV elections. In small instances, these algorithms are able to compute exact margins.
Continuous-Time Portfolio Choice Under Monotone Mean-Variance Preferences—Stochastic Factor Case
Authors: Trybuła Jakub , Zawisza Dariusz
Published: May 2019

We consider an incomplete market with a nontradable stochastic factor and a continuous-time investment problem with an optimality criterion based on monotone mean-variance preferences. We formulate it as a stochastic differential game problem and use Hamilton–Jacobi–Bellman–Isaacs equations to find an optimal investment strategy and the value function. What is more, we show that our solution is also optimal for the classical Markowitz problem, and every optimal solution for the classical Markowitz problem is optimal also for the monotone mean-variance preferences. These results are interesting because the original Markowitz functional is not monotone, and it was observed that in the case of a static one-period optimization problem, the solutions for those two functionals (monotone mean variance and classical Markowitz) are different. In addition, we determine explicit Markowitz strategies in the square root factor models.
All about … settling in to school a child's perspective
Authors: Barker Beth , Tatlow-Golden Mimi , Booth Ailbhe , O'Farrelly Christine
Published: May 2019

What are children's real experiences of making the transition from early years setting to Reception? By the researchers behind the Children's Thoughts about School Study Beth Barker, Mimi Tatlow-Golden, Ailbhe Booth and Christine O'Farrelly
Artificial Neural Networks in Medicine
Authors: Kocsis Zoltan Tamas
Published: May 2019

In recent years, Information Technology has been developed in a way that applications based on Artificial Intelligence have emerged. This development has resulted in machines being able to perform increasingly complex learning processes. The use of Information Technology, including Artificial Intelligence is becoming more and more widespread in all fields of life. Some common examples are face recognition in smartphones, or the programming of washing machines. As you may think, Artificial Intelligence can also be used in medicine. In this study I am presenting the relationship between machine learning and neural networks and their possible use in medicine.
PENGOPERASIAN RFID SEBAGAI OPERATING USER PARKING AREA DENGAN METODE ELEKTRONIK PARKING PRICING (EPP) BERBASIS ARDUINO UNO
Authors: Wijayanto Ari , Sasmoko Priyo
Published: May 2019

Ari Wijayanto, Priyo Sasmoko, in this paper explain that for operation RFID Parking Area User Operating Method Electronic Parking Pricing ( EPP ) Based Arduino Uno we created to see the problems that occur at this time , where the application of the parking area where the management is still done manually, especially in terms of payments .. We design a tool capable overcome these weaknesses , ranging from providing information about the availability of parking space to the user before entering the parking area to the effectiveness of the method of payment , which uses an identity card balance . With this tool is expected to reduce queuing/ speed up queues of vehicles wanting to enter / exit the parking lot. The system is also supported by the Arduino Uno as the brain to process data from RFID . RTC components to calculate the time and date , LCD display , and a servo motor as the driving door portal. Infrared to close the portal and counting vehicles entering and exiting. Keywords : RFID, Operating User Parking Area, EPP, Arduino UnoReferencesMalvino. 1995. Prinsip-prinsip Elektronkasi. Jakarta : Erlangga.Van Vlack. Lawrench, Ilmu dan Teknologi Bahan, Erlangga, hal 186Djuaji, Very. 2011, Pengenalan Arduino. hal.9Finkenzeller Klaus, 2010, RFID Handbook, 319Elektuur, B.V. 1986. 301 Rangkaian. Diterjemahkan oleh: Ignatius. Jakarta: Elex Media Komputindo.Tri, 2014 Metode Penulisan Karya Ilmiah, Bandung: Kelompok keahlian Ilmu Kemanusian Institut Teknologi Bandung.Jogiyanto, 2003, Konsep dasar Pemrograman Bahasa C, Yogyakarta: Andi.Annonimous. 2012. Mengenal Arduino UNO. Diunduh dari http://www.sahabat-informasi.com/2012/07/mengenal-arduino-uno.html pada 25 mei pukul 20.02 WIB.
POWER BANK PORTABLE SOLAR CHARGER MENGGUNAKAN SISTEM BUCK-BOOST CONVERTER BERBASIS MIKROKONTROLER ATMEGA 32
Authors: Elfani Nisrina Zahra , Sasmoko Priyo
Published: May 2019

Nisrina Zahra Elfani, Priyo Sasmoko explain that portable electronic devices have a problem, namely the resistance of electrical energy intake, because these electronic devices get energy from batteries that have limited capacity to store electrical energy. Electronic objects that have now mushroomed and become primary needs such as cellphones and laptops desperately need a tool to recharge batteries. Solar energy can be used to recharge the gatget batteries by converting them to electric power. This will be very useful for those who are field workers, travelers, and nature lovers who need battery charging devices without having to use an adapter that uses an AC source from PLN grids in homes, while in certain circumstances gadget users may not be at home or in a place that provides ac resources. One solution to this problem is the use of a power bank portbale solar charger. Portable power bank solar charger is a charger that is equipped with backup batteries and solar cells as a source of electrical energy. Realized a portable charger that uses the working principles of DC-DC converter circuits such as: buck-boost converter, buck converetr and boost converter as a voltage regulator that is used to charge electronic devices. The ADC channel on the microcontroller is used as feedback for the controller that is also present in the microcontroller used so that the converter output can be maintained at a certain value through setting the duty cyle PWM that drives the converter. This portable power bank solar charger uses a buck-boost converter system and can produce the desired voltage. Buck converters can reduce the output voltage from 5 Volt dc for the use of chargering handphone and boost converter can increase the output voltage around 19 volts dc for the use of notebook charging Keywords: powerbank, portable charger, buck-boost converter, solar cellReferencesGunawan. 2009. Rancang Bangun DC-Dc Converter dengan PID Diskrit sebagai Pengendali Tegangan Keluaran. Skripsi. Depok :  Fakultas Teknik, Program Studi Elektro, Universitas  Indonesia. Handini, Wulandari. 2008. Performa Sel Surya Tersensitasi Zat Pewarna (DSSC) Berbasis ZnO dengan Variasi Pengisian dan Besar Kristalis Ti . Skripsi. Depok : Fakultas Teknik, Program Studi Elektro, Universitas  Indonesia.Hidayat, Suryo, Muhamad. 2010. Rancang Bangun buck Boost Konverter.  Skripsi. Depok : Fakultas Teknik, Program Studi Elektro, Universitas  Indonesia
DESAIN SISTEM KENDALI UMPAN BALIK STATE PADA KASUS KONTINYU UNTUK MEJA KERJA CNC
Authors: Mangkusasmito Fakhruddin , Nugroho Tsani Hendro
Published: May 2019

Fakhruddin Mangkusasmito, Tsani Hendro Nugroho in this paper explain that One of the important control system in the manufacturing industry is the position control. Mainly in the Computer Numerical Control (CNC) machine, work-table motion control system is used to regulate work-table movements when the machine process a workpieces on it. On standard machines, work-table movements are two axes (X-Y), which is driven by a motor and lead-screw. The discussion in this research only focus on one axis assuming that the systems on both axes are the same and independent. In this research, MATLAB is used to describe the behaviour of the system and also to design appropriate control system in continuos system using state feedback linear controller such as pole placement , tracking system, full order compensator and reduced order compensator. The goal is to obtain a fast response with a rapid rise time and settling time to a step command, while not exceeding an overshoot of 5%. The specification are than a percent overshoot equal to1%, 0,05s settling time and 0,03s rise time. The performance of each control methods are simulated and analyzed to decide the best suit control method for the systems with such criteria. And the result verify that using tracking system controller method achieve such specification with 0% overshoot, 0,04s settling time and 0,028s rise time.
SIMULASI PENENTUAN LOKASI GANGGUAN SATU FASA PADA JARINGAN TEGANGAN MENENGAH 20 KV BERBASIS ARDUINO MEGA 2560 DILENGKAPI DENGAN MONITORING MELALUI VTSCADA
Authors: Ashifa Danu Nur , Subari Arkhan
Published: May 2019

Danu Nur Ashifa, Arkhan Subari in this paper explain that in a distribution network of 20 KV, short circuit interference often occurs. Short circuit interference will produce a fault current that is felt by protection equipment. Each fault current will differ depending on the distance of the interference. Determining the distance of interference can not be displayed in SCADA, SCADA will only display the amount of interference and which equipment works. Determination of distance is carried out after analysis by the officer. Based on this matter the compiler makes a simulation tool where the tool can monitor the location of the disturbance from the nearest protective equipment that feels a single phase short circuit interference. The simulation tool consists of Arduino Mega 2560 which functions as a control center. The input used is a potentiometer as a simulator of the impedance magnitude that occurs during a single phase short circuit where the potentiometer will provide input in the form of a signal. And Omron LY2N relay which functions as protection equipment. After the experiment, the results obtained are that the tool can determine the location of interference from the nearest protection equipment based on changes in the bits read by Arduino. The larger the bits read by Arduino, the more distant the interference occurs from the protection equipment. 125 bits will produce an Arduino impedance calculation of 2.6 ohms so that the fault location is 0 km from PMT while 1023 bits will produce an impedance calculation of 21.30 ohms so that the fault location is 4.5 km from SSO.
Inflammatory Response to Acute Myocardial Infarction Complicated by Cardiogenic Shock
Authors: Pudil Radek , Krejsek Jan , Pidrman Vladimír , Gregor Jaroslav , Tichý Miloš , Bureš Jan
Published: May 2019

We report a case of a 60-year-old man with acute myocardial infarction (AMI) treated using thrombolysis, and complicated by cardiogenic shock (CS). Plasma interleukin (IL) 1β, IL 6, IL 8, tumor necrosis factor alpha (TNFα), and soluble adhesion molecule (sICAM 1, sE-selectin) levels were measured at 3-h intervals. This observation showed the effect of AMI and CS on the plasma interleukin levels. Remarkable changes were found in the plasma TNF α level, which reached two significant peaks. The peak of the first elevation caused by AMI (80.11 pg/ml, vs. normal value 4.35 pg/ml, SD 21.3 pg/ml) was seen 6 h after the onset of the symptoms. After the period of significant decrease, TNF α level was increasing until the end of the observation period because of CS (the last TNF α level was 204.1 pg/ml). The plasma IL 1β level was continually increased during the period of observation (maximal IL 1β level 32.1 pg/ml, normal value <10 pg/ml). The plasma IL 6 level reached the first peak caused by AMI nine hours after the onset of the symptoms (362.85 pg/ml, normal value (10 pg/ml). Because of CS, after the short period of decrease, the plasma IL 6 level was increasing until the end of the observation period (the last IL 6 level was 859.61 pg/ml). The plasma IL 8 level was also elevated throughout the time of observation (max. value 1652 pg/ml, vs. normal value <30pg/ml). The soluble adhesion molecule levels (sE-selectin and sICAM 1) were elevated throughout the period of observation without any significant peak.
Wielowymiarowość rozumienia pojęć mythos i logos z perspektywy zasady dziejów skutkujących Hansa-Georga Gadamera
Authors: Szymczyński Tomasz R.
Published: May 2019

Wyprowadzona przez twórcę hermeneutyki filozoficznej Hansa-Georga Gadamera zasada dziejów skutkujących, pozostając w bezpośredniej relacji z jego figurą horyzontu, jego wykładnią m.in. takich pojęć jak rozumienie, tradycja, przesądy-przedsądy, stanowi w niniejszym artykule podstawę dla próby zastosowania zaleceń powyższej konstrukcji myślowej dla naświetlenia przemian, jakie dokonały się na osi czasu w obszarze rozumienia pojęć mythos i logos. W rezultacie na bardziej ogólnym poziomie wyłania się krytyczne ujęcie często obecnego współcześnie instrumentalnego traktowania zarówno pytań, jak i pojęć stanowiących zasadnicze aspekty płaszczyzny językowej. Natomiast na poziomie bardziej szczegółowym ukazuje się teza o swoiście poza-starogreckich źródłach opozycji mitu i rozumu w europejskiej kulturze nowożytnej.
Espionage against Poland in the Documents and Analyses of the Polish Special Services (1944–1989) – as Illustrated by the Intelligence Activities of the USA
Authors: Rosicki Remigiusz
Published: May 2019

Tekst omawia problem działalności szpiegowskiej wobec Polski w okresie 1944–1989. Analiza ta została wzbogacana danymi ilościowymi z okresu 1944–1984 w zakresie skazań za udział w obcym wywiadzie, działanie na jego rzecz oraz przekazywanie informacji. Problematykę szpiegostwa przedstawiono na przykładzie działalności USA, co zostało zobrazowane przykładami poszczególnych osób, które zostały skazane za działalność szpiegowską. W rozważeniu problemu badawczego posłużono się dokumentami i analizami opracowanymi przez Ministerstwo Spraw Wewnętrznych, głównie przeznaczonymi dla pracowników Służby Bezpieczeństwa i Milicji Obywatelskiej. W pracy podjęto się zweryfikowania następujących pytań badawczych: (1) W jakim stopniu charakter systemu społeczno-politycznego wpływał na liczbę skazań za szpiegostwo wobec Polski w analizowanym okresie 1944–1989?; (2) Jaki był poziom zainteresowania wywiadowczego obcych służb specjalnych Polską przed 1990 r.?; (3) Czy można wskazać na specyfikę działalności wywiadowczej USA przeciw Polsce?
Long-Scale Ollivier Ricci Curvature of Graphs
Authors: Cushing D. , Kamtue S.
Published: May 2019

We study the long-scale Ollivier Ricci curvature of graphs as a function of the chosen idleness. Similarly to the previous work on the short-scale case, we show that this idleness function is concave and piecewise linear with at most 3 linear parts. We provide bounds on the length of the first and last linear pieces. We also study the long-scale curvature for the Cartesian product of two regular graphs.
The potential therapeutic actions of melatonin in colorectal cancer
Authors: Chok Kian Chung , Ng Chew Hee , Koh Rhun Yian , Ng Khuen Yen , Chye Soi Moi
Published: May 2019

Colorectal cancer (CRC) is the third most common cancer and lethal disease worldwide. Melatonin, an indoleamine produced in pineal gland, shows anticancer effects on a variety of cancers, especially CRC. After clarifying the pathophysiology of CRC, the association of circadian rhythm with CRC, and the relationship between shift work and the incidence of CRC is reviewed. Next, we review the role of melatonin receptors in CRC and the relationship between inflammation and CRC. Also included is a discussion of the mechanism of gene regulation, control of cell proliferation, apoptosis, autophagy, antiangiogenesis and immunomodulation in CRC by melatonin. A review of the drug synergy of melatonin with other anticancer drugs suggests its usefulness in combination therapy. In summary, the information compiled may serve as comprehensive reference for the various mechanisms of action of melatonin against CRC, and as a guide for the design of future experimental research and for advancing melatonin as a therapeutic agent for CRC.
Comparison of lipidic carrier systems for integral membrane proteins – MsbA as case study
Authors: Kehlenbeck Dominique-Maurice , Josts Inokentijs , Nitsche Julius , Busch Sebastian , Forsyth V. Trevor , Tidow Henning
Published: May 2019

Membrane protein research suffers from the drawback that detergents, which are commonly used to solubilize integral membrane proteins (IMPs), often lead to protein instability and reduced activity. Recently, lipid nanodiscs (NDs) and saposin-lipoprotein particles (Salipro) have emerged as alternative carrier systems that keep membrane proteins in a native-like lipidic solution environment and are suitable for biophysical and structural studies. Here, we systematically compare nanodiscs and Salipros with respect to long-term stability as well as activity and stability of the incorporated membrane protein using the ABC transporter MsbA as model system. Our results show that both systems are suitable for activity measurements as well as structural studies in solution. Based on our results we suggest screening of different lipids with respect to activity and stability of the incorporated IMP before performing structural studies.
Associations of physical activity or sedentary behaviour with pain sensitivity in young adults of the Raine Study
Authors: Waller Robert , Smith Anne , Slater Helen , O’Sullivan Peter , Beales Darren , McVeigh Joanne , Straker Leon
Published: May 2019

Background and aims

There is high level evidence for physical activity (PA) improving outcomes in persistent pain disorders and one of the mechanisms proposed is the effect of exercise on central nociceptive modulation. Although laboratory studies and small field intervention studies suggest associations between physical activity and pain sensitivity, the association of objectively measured, habitual PA and sedentary behaviour (SB) with pain sensitivity requires further investigation. Current evidence suggests PA typically lowers pain sensitivity in people without pain or with single-site pain, whereas PA is frequently associated with an increase in pain sensitivity for those with multisite pain. The aim of this study was to explore the relationships of PA and SB with pain sensitivity measured by pressure pain thresholds and cold pain thresholds, considering the presence of single-site and multisite pain and controlling for potential confounders.

Methods

Participants from the Western Australian Pregnancy Cohort (Raine) Study (n = 714) provided data at age 22-years. PA and SB were measured via accelerometry over a 7-day period. Pain sensitivity was measured using pressure pain threshold (4 sites) and cold pain threshold (wrist). Participants were grouped by number of pain areas into “No pain areas” (n = 438), “Single-site pain” (n = 113) and “Multisite pain” (n = 163) groups. The association of PA and SB variables with pain sensitivity was tested separately within each pain group by multivariable regression, adjusting for potential confounders.

Results

For those with “Single-site pain”, higher levels (>13 min/day) of moderate-vigorous PA in ≥10 min bouts was associated with more pressure pain sensitivity (p = 0.035). Those with “Multisite pain” displayed increased cold pain sensitivity with greater amounts of vigorous PA (p = 0.011). Those with “No pain areas” displayed increased cold pain sensitivity with decreasing breaks from sedentary time (p = 0.046).

Conclusions

This study was a comprehensive investigation of a community-based sample of young adults with “No pain areas”, “Single-site pain” and “Multisite pain” and suggests some associations of measures of PA and SB with pain sensitivity.

Implications

The findings suggest that the pattern of accumulation of PA and SB may be important to inform improved clinical management of musculoskeletal pain disorders. This study provides a baseline for follow-up studies using the Raine Study cohort. Future research should consider temporal influences of PA and SB on pain sensitivity, pain experience and consider using a broader range of pain sensitivity measures.
Zum Status und zu Funktionen der -n-\-t-Partizipien in polnischenmieć-Formen
Authors: Bartelik Piotr
Published: May 2019

This paper is an attempt to elaborate the various functions of the -n-\-t- participles in Polish periphrastic constructions with the verbmieć‘to have’. Starting with the well-known basic assumption that there are significant tensions between different adjectival and verbal features of the participles in various constructions an attempt to the thorough analysis and description of their argument and event structure in themieć-constructions with one, two and three place verbs has been made. It has shown that the diathetic ambiguities of the participles are still present in the elaborated forms, which are encoding with transitive verbs above all causative events and in which the agent role cannot be specified at first glance. Therefore other relevant factors, such as object and subject properties, which can largely influence the agent interpretation, should be included in the analysis, too. Furthermore, it is also emphasized that the reorientation of the participles can depend on their position regarding the clause object. The preliminary theses and research results presented in this paper can be further developed and evaluated on data from other Slavonic languages which show comparable constructions withhave-verbs.
Zum Prosaautor Dragoslav Mihailović – Eine Übersicht
Authors: Hodel Robert
Published: May 2019

The present contribution gives an overview of the prose by the Serbian writer Dragoslav Mihailović (1930) from the early skaz narratives to the documentary work Goli otok. This opus shows, as a whole, the following features: Mihailović tells whole life stories, which put more focus on action than on psychological description. Most of the stories are dominated by a subjective point of view and are marked linguistically (dialects, sociolects, vigorous colloquiality). Mihailović’s heroes are mostly on the social fringe, yet the view of these marginalized people is less socially critical than humanistic and individualistic. Most of the fictional characters are based on actual people, whom the writer got to know at close range in the course of his odyssey – the author has become an orphan at a young age and was put into prison on Goli otok island when he was barely 20 years old.
Cellular and molecular mechanisms of PIK3CA-related vascular anomalies
Authors: Le Cras Timothy D , Boscolo Elisa
Published: May 2019

The phosphoinositide 3-kinase (PI3K) pathway is a major mediator of growth factor signaling, cell proliferation and metabolism. Somatic gain-of-function mutations in PIK3CA, the catalytic subunit of PI3K, have recently been discovered in a number of vascular anomalies. The timing and origin of these mutations remain unclear although they are believed to occur during embryogenesis. The cellular origin of these lesions likely involves endothelial cells or an early endothelial cell lineage. This review will cover the diseases and syndromes associated with PIK3CA mutations and discuss the cellular origin, pathways and mechanisms. Activating PIK3CA ‘hot spot’ mutations have long been associated with a multitude of cancers allowing the development of targeted pharmacological inhibitors that are FDA-approved or in clinical trials. Current and future therapeutic approaches for PIK3CA-related vascular anomalies are discussed.
Unternehmerische Produktentwicklung in Zeiten des Umbruchs hin zum Produkt-Service-Mix
Authors: Seidenschwarz Werner
Published: May 2019

In Zeiten des Umbruchs von Märkten und Technologien steht auch die unternehmerische Produktentwicklung vor neuen Herausforderungen. Der Beitrag zeigt, wie es Unternehmen mit einer strategiebasierten Steuerung des PLM - Prozesses, richtiger Priorisierung und marktnah entwickelten Lösungen mit Target Costing auch in disruptiven Zeiten gelingen kann, ihre Kunden mit einem werthaltigen Produkt-Service-Mix zu begeistern. Darüber hinaus werden sechs Handlungsfelder identifiziert, die für eine Weiterentwicklung bestehender Entwicklungslandschaften wegweisenden Charakter haben.
Management technischer Produktänderungsprojekte
Authors: Gebhardt Marcel
Published: May 2019

Die Durchführung kundeninduzierter Produktänderungen ist für viele Unternehmen ein zentrales Erfolgskriterium. In der Praxis steht das Auftrags-Pricing häufig im Fokus und stellt Unternehmen vor vielfältige Herausforderungen, da bereits vor Angebotserstellung alle Kosten näherungsweise bekannt sein müssen. Ein Blick in die Literatur zeigt, dass für die Quantifizierung sog. indirekter Änderungskosten keine fundierten Prognoseansätze existieren. Der Beitrag widmet sich dieser Lücke. Er ist ein Auszug aus der Dissertation von Marcel Gebhardt und stellt ein parametrisches Kostenprognosemodell vor.
Unternehmenssteuerung bei Open Grid Europe zwischen Regulierung und Energiewende
Authors: Reiners Frank , Pedell Burkhard
Published: May 2019

Open Grid Europe mit Sitz in Essen ist mit einem Leitungsnetz von rund 12.000 Kilometern – in etwa entsprechend der Länge des deutschen Autobahnnetzes – einer der großen Fernleitungsnetzbetreiber in Europa. Die Kerntätigkeiten von Open Grid Europe umfassen die Planung und den Bau von Leitungen, den Betrieb des Leitungssystems, das Management und die Vermarktung der Kapazitäten sowie die Mengenermittlung und Abrechnung. Open Grid Europe ist ein 100%iges Tochterunternehmen der Vier Gas Transport GmbH (VGT), hinter der ein Konsortium aus Finanzinvestoren steht: Macquarie European Infrastructure Fund 4, Abu Dhabi Investment Authority, British Columbia Investment Management Corporation und MEAG MUNICH ERGO Asset Management. Der VGT-Konzern erwirtschaftete mit rund 1.400 Mitarbeitern im Geschäftsjahr 2018 Umsatzerlöse von 1 Mrd. Euro und ein Ergebnis vor Steuern, Zinsen und Abschreibungen (EBITDA) von rund 526 Mio. Euro. Die Konzerninvestitionen betrugen 469 Mio. Euro. (Quelle: www.viergas.de)
Remote Management of Heart Failure: An Overview of Telemonitoring Technologies
Authors: Brahmbhatt Darshan H , Cowie Martin R
Published: May 2019

Technological advances have enabled increasingly sophisticated attempts to remotely monitor heart failure. This should allow earlier identification of decompensation, better adherence to lifestyle changes and medication and interventions (such as diuretic dosage changes) that reduce the need for hospitalisation. This review discusses telemonitoring approaches in heart failure, and the evidence for their impact. It is not difficult to collect data remotely, but converting more data into better decision-making that improves the outcome of care is challenging. Policy-makers and technology companies are enthusiastic about the potential of digital technologies to transform healthcare and bring expertise to the patient, rather than the other way round, but guideline writers are not yet convinced, due to the lack of consistent findings in randomised trials.
La búsqueda de la identidad musical en el México posrevolucionario. De los ritmos regionales a los nacionales.
Authors: Cruz Carvajal Cristina
Published: May 2019

El presente artículo aborda el periodo del México posrevolucionario (1920-1940), donde se experimenta por primera vez, una situación de relativa estabilidad. Eso provoca que quienes se encuentran en el poder busquen, en coordinación con la población de la nación, un estilo musical que identifique a México en el ámbito internacional. Así como a España lo identifica el flamenco, o a Argentina el tango, en México se elige a la música de mariachi, o ranchera como la que identifique hacia el exterior. En el ámbito interno esto provocó una disputa, ya que el país es muy diverso, y varios estilos regionales chocan. Por ello, desde el estado se genera el surgimiento del nacionalismo, que motivó a una caracterización interna, así como un sentimiento de identificación hacia lo que comienza a significar México. Así, la presente comunicación, presenta desde una perspectiva histórica, a través de la investigación en diversas fuentes, cómo es que en México se generó esa identidad musical que aún tiene repercusiones en la actualidad.
JÓVENES RURALES: TRABAJO Y MOVILIDADES ESPACIALES EN UNA REGIÓN HORTÍCOLA EN ARGENTINA
Authors: Marioni Lucía , Schmuck Emilia
Published: May 2019

En este artículo se abordan las prácticas y las representaciones acerca del trabajo y las movilidades espaciales de jóvenes de familias de pequeños productores hortícolas de Argentina. La investigación se realizó entre junio de 2016 y junio de 2017 a partir de una estrategia etnográfica. Entre los aportes se señalan la invisibilización y las desigualdades de género en el trabajo, así como, se caracterizan las movilidades espaciales cotidianas entre lo que las juventudes identifican como espacios antagónicos: “el campo” y “la ciudad”.
ENFOQUES ANALÍTICOS EN TORNO AL COMERCIO SEXUAL DE LAS MUJERES: COORDENADAS CONTEMPORÁNEAS E INDAGACIONES EN PERSPECTIVA HISTÓRICA
Authors: Coppa Lucía Inés
Published: May 2019

En este artículo se busca recomponer algunas perspectivas y enfoques presentes en las investigaciones contemporáneas en torno al mercado del sexo. Para ello, se proponen dos ejes a modo de organizar esta revisión: por un lado, se presenta una serie de claves y coordenadas contemporáneas para una aproximación a los abordajes actuales ligados a la configuración contemporánea de los mercados sexuales; por otro lado, se remiten perspectivas que historiográficamente han contribuido a conocer las tramas del comercio sexual de modo situado. La revisión conjunta de los problemas que estas indagaciones plantean, que en general suelen abordarse de manera disociada de acuerdo a su correspondencia disciplinar con estudios contemporáneos o en perspectiva histórica, puede contribuir a un diálogo fructífero habilitando terrenos de indagación a partir de nuevos enfoques o preguntas, así como, la formulación de nuevas áreas problemáticas.
ESTADO, TERRITORIO Y POBLACIÓN INDÍGENA
Authors: Camacho Monge Daniel
Published: May 2019

En nuestra temática central titulada “estado, territorio y población indígena”, Carballo y Madrigal realizaron un estudio en la población indígena Cabécar-Tayní, ubicada en la provincia de Limón, Costa Rica, para recolectar y analizar sus apreciaciones del paisaje a partir de sus relatos de vida y de la estética del lugar, con la finalidad de comprender los espacios naturales, ambientales, culturales, étnicos y sociales en los que se han desenvuelto esta población. Por su lado, Engelman estudia desde la perspectiva de las políticas públicas, dinámicas sociales de las poblaciones indígenas en el municipio de Almirante Brown de la Región Metropolitana de Buenos Aires (RMBA ), Argentina, con el objetivo de documentar el proceso de visibilización y organización etnopolítica local que han emprendido estas organizaciones, lo cual ha permitido mayor presencia política y étnica, una visión positiva de lo indígena y un empoderamiento de la población. Barrera-Rojas, Sánchez-Carballo, Ruíz-Sánchez y Ruiz-Guevara, investigan las condiciones de pobreza que enfrentan las mujeres indígenas en la Zona Maya de Quintana Roo, México. Para ello, utilizaron tres indicadores de pobreza: Línea de pobreza extrema propuesta por el Banco Mundial, Línea de bienestar mínimo y Línea de bienestar propuestas por el Consejo Nacional de Evaluación de la Política de Desarrollo Social.
Range extension of Redside Barb, Puntius bimaculatus (Bleeker, 1863) (Cypriniformes, Cyprinidae), from the Nallamalla and Sheshachalam Hill Ranges of the Eastern Ghats, India
Authors: Prasad Kante Krishna , Srinivasulu Chelmala
Published: May 2019

We report new distribution records of Redside Barb (Puntius bimaculatus), a species of freshwater fish, for the first time from the Nallamala Hill Ranges of Nagarkurnool and Nalgonda districts (Telangana state), and the Seshachalam Hills in Kadapa district (Andhra Pradesh). We provide a brief description of earlier reports and a detailed description of this species.
New distribution records for Sciomyzidae (Diptera) from the Pantanal, Brazil
Authors: Savaris Marcoandre , Kirst Frederico Dutra , Lampert Silvana , Marinoni Luciane
Published: May 2019

We document the geographical distribution of 6 species of Sciomyzidae from the Pantanal biome of Brazil. The species were collected in aquatic or semi-aquatic habitats from Mato Grosso and Mato Grosso do Sul. Sepedomerus bipuncticeps (Malloch, 1933) and Sepedonea canabravana Knutson & Bredt, 1976 are new records from Mato Grosso and Sepedonea lindneri (Hendel, 1932), Sepedonea telson (Steyskal, 1951), Sepedonea veredae Freidberg, 1991, and Thecomyia limbata (Wiedemann, 1819) from Mato Grosso do Sul. Photographs of collection areas, the habitus of adults, and a distribution map of the species are provided.
An ELL’s journey in learning to demonstrate solidarity in job application letters
Authors: Portman Daniel , Coffin Caroline
Published: May 2019

In recent years, tertiary institutes worldwide have begun to emphasize capacity building of their students for future employment, particularly with regard to international mobility. An integral part of building such capacity among English language learners (ELLs) is to equip them with the ability to apply for jobs in English. This paper reports on a research project which tracked, over the course of eight weeks an Israeli English language learner’s improved understanding of how to write a US-oriented job application letter. Using the theoretical framework of systemic functional linguistics (cf. Halliday and Matthiessen, 2004), we present the results of a fine grained linguistic analysis of the texts produced by a student at three different points in the learning process. Against the background of a large corpus of linguistically analysed successful job application letters, the paper focuses on the extent to which the student developed in managing the applicant-potential employer relationship, which we call ‘demonstrating solidarity’, as evidenced through his changing use of interpersonal linguistic resources. We interpret the student’s development in light of cross-cultural differences that might have influenced his learning trajectory. The paper concludes by setting out the most significant implications of the findings for pedagogic practice and institutional policy, especially important for English language learners.
A ‘functional’ projection from visual contrast to mode
Authors: Yang Xiran
Published: May 2019

In multimodal visual narratives such as Japanese manga, meaning is created through components of different modes - from verbals to onomatopoeias, emblems, and graphics. With the aim of integrating different modes (from text to image) so as to suggest an integrated solution that collectively defines the composing elements of comics, this paper proposes a Function of Mode, which applies semiotic and mathematical principles to expound on the subconscious process of recognizing visual contrasts that are drawn, printed or digitally displayed into various modes that form the building blocks of multimodal discourse. This function sits at the base of multiliteracy for understanding multimodal visual narrative and enables the reader to distinguish different modes by accentuating relevant semiotic channels of meaningmaking - iconicity for imagistic description, symbolization for linguistic features, entitativity for metaphorizing and visualizing non-graphic images, and diegesis for demarcating which elements are meaningful, ideationally or interpersonally.
Students Perspectives on Holistic Mentoring Practices in STEM Fields
Authors: Luedke Courtney L. , McCoy Dorian L. , Winkle-Wagner Rachelle , Lee-Johnson Jamila
Published: May 2019

This critical multi-site case study examined the holistic mentoring practices provided by faculty to Students of Color in STEM fields at a predominantly White institution and a historically Black institution.  We employed Bourdieu’s social reproduction theory to examine the ways in which social capital developed through faculty-student mentoring relationships led to the accumulation of cultural capital valued in STEM fields and higher education more broadly.
Uberização do trabalho: um fenômeno de tipo novo entre os docentes de São Paulo, Brasil?
Authors: Venco Selma
Published: May 2019

Resumo: O presente ensaio visa a problematizar e discutir em que medida a uberização do trabalho se caracteriza, de fato, como um fenômeno de tipo novo. O estudo apoia-se em pesquisas qualitativas e em análise documental referentes às formas de contratação entre 1999 e 2017. Procede-se, para tal análise, à construção do processo histórico das práticas concernentes às relações de trabalho pelo Governo Estadual de São Paulo, Brasil, as quais são marcadas pela flexibilização intencional, orientadas pelos princípios intrínsecos da Nova Gestão Pública. Constata-se que a empresa Uber, para além da economia digital, propagou formas ainda mais flexíveis das observadas durante e após a reestruturação produtiva, propalando e visibilizando o trabalhador sem contrato, a intensificação do trabalho e os ganhos minimizados. A correspondência com o trabalho docente recupera as raízes históricas da fundação das relações precárias com a categoria e revela que tais características não se configuram como de tipo novo entre os que exercem a profissão. Averiguam-se características semelhantes às praticadas pela Uber e, portanto, conclui-se que há um processo de quasi-uberização concernente ao trabalho docente. Apreende-se, igualmente, a presença de fortes sinais do esfacelamento dos coletivos, posto que se divide em três grupos, identificados nos estudos realizados. Cada grupo apresenta particularidades que acentuam as nuances dos processos de individualização no trabalho, estratégia acoplada ao gerencialismo e à constatação de que o neoliberalismo atinge os indivíduos, alterando valores e subjetividades, exaltando a competitividade e o individualismo nos processos de trabalho.
Análise das Simulações do PMIP3 Sobre o Nordeste Brasileiro Para o Período Pré-Industrial e Holoceno Médio
Authors: Dias Tyhago Aragão , Costa Alexandre Araújo , Sousa Filho Francisco de Assis , Silveira Cleiton da Silva
Published: May 2019

Resumo Este trabalho mostra uma analise das simulações obtidas no banco de dados do PMIP3 (Paleoclimate Modelling Intercomparison Project Phase IIII) para o período pré-industrial com os dados observados pelo CMAP (Climate Prediction Center Merged Analysis of Precipitation) e Climatic Reserch Unit (CRU) para a precipitação pluviométrica em mm/mês e os dados de reanálise do NCEP/NCAR para a temperatura do ar a 2 m acima da superfície em graus Celsius, para as região do Nordeste Brasileiro (NEB) (46° W - 34° W; 16° S - 2° S), a fim de encontrar um conjunto de modelos com representação realista do clima do presente. Em seguida, uma comparação é feita entre os resultados das simulações desses modelos para o período pré-industrial (PI) e o Holoceno médio (HM, ~6.000 anos atrás), a fim de identificar possíveis mudanças climáticas entre esses períodos sobre a América do Sul. Esses modelos do PMIP3 sugerem que houve diferenças importantes entre o clima atual e o do Holoceno Médio no que diz respeito à intensidade da monção da América do Sul (monção mais fraca no HM do que no presente).
Physiological response of marandu grass seeds exposed to NPK fertilizer
Authors: Codognoto Luciane da Cunha , Conde Thassiane Telles , Maltoni Kátia Luciene , Faria Glaucia Amorim , Reis André Rodrigues dos
Published: May 2019

ABSTRACT: To facilitate seeding process of forage species, a common practice is to mix seeds with fertilizers in monocropping and intercropping or in implementing integrated livestock production systems. However, in prolonged periods of contact, the fertilizer’s salinity and acidity negatively affect the seeds’ physiological quality. Therefore, this study intends to verify the effect of ten periods (0, 3, 6, 12, 24, 36, 48, 72, 96, and 120 hours) of exposure to granular NPK fertilizer 04-30-16 on the vigor and germination of Urochloa brizantha cv. Marandu seeds. The experiment was conducted in a completely randomized design with three replication. The fertilizer and seed mixture registered a negative effect on seed moisture content, electrical conductivity, emergence, emergence speed index, and seedling and radicle length as the period of exposure to the fertilizer increased from 3 to 120 hours.
PROXIMAL HUMERAL FRACTURES TREATED WITH OSTEOSYNTHESIS USING THE ANTEROLATERAL APPROACH
Authors: Mouraria Guilherme Grisi , Zoppi Filho Américo , Kikuta Fernando Kenji , Moratelli Lucas , Silveira Junior Paulo Pedroso , Etchebehere Maurício
Published: May 2019

ABSTRACT Objective: The main surgical approach in proximal humeral fractures is the deltopectoral approach. Many surgeons avoid the anterolateral approach, fearing its complications, especially axillary nerve injury. The objective of this study is to evaluate shoulder function and complications in patients with proximal humeral fractures treated using an anterolateral approach with direct observation of the axillary nerve. Methods: Retrospective study with postoperative radiological and functional evaluations (Constant and DASH scores) and review of the complications. The associations between fracture classification and the difference in Constant scores among the subjects and the final angle of consolidation were analyzed using Fisher's test or analysis of variance (ANOVA). The Constant scores were compared among the shoulders using the paired t-test. Results: The study evaluated 35 patients. Shoulder function was decreased, compared with the contralateral side (p<0.005). The only factor related to functional worsening was the Neer IV fracture. The main complication was malunion. There were no clinical changes related to the axillary nerve. Conclusion: The treatment using the extended anterolateral approach produced good functional results, although the function was decreased (Neer IV fractures). The main complication was malunion. There were no side effects due to exposure of the axillary nerve. Level of evidence III, Retrospective Study.