bluuebunny/crossref_metadata_2025 huggingface dataset:
Controlling Liquid Crystal Configuration and Phase Using Multiple Molecular Triggers
Authors: Oster Linda M. , Shechter Jake , Strain Benjamin , Shivrayan Manisha , Thayumanavan Sankaran Thai , Ross Jennifer L.
Published: January 2022

Liquid crystals are able to transform a local molecular interaction into a macroscopic change of state, making them a valuable “smart” material. Here, we investigate a novel polymeric amphiphile as a candidate for molecular triggering of liquid crystal droplets in aqueous background. Using microscopy equipped with crossed polarizers and optical tweezers, we find that the monomeric amphiphile is able to trigger both a fast phase change and then a subsequent transition from nematic to isotropic. We next include sodium dodecyl sulfate (SDS), a standard surfactant, with the novel amphiphilic molecules to test phase transitioning when both were present. As seen previously, we find that the activity of SDS at the surface can result in configuration changes with hysteresis. We find that the presence of the polymeric amphiphile reverses the hysteresis previously observed during such transitions. This work demonstrates a variety of phase and configuration changes of liquid crystals that can be controlled by multiple exogenous chemical triggers.
Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action
Authors: Choi Peter Jaein , Tomek Petr , Tercel Moana , Reynisson Jóhannes , Park Thomas In Hyeup , Cooper Elizabeth Alexandra , Denny William Alexander , Jose Jiney , Leung Euphemia
Published: January 2022

The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in the highly aggressive, triple-negative breast cancer that lacks sensitivity to chemotherapy or endocrine therapy. We hypothesized that conjugation of the near-infrared dye MHI-148 with palbociclib can produce a potential theranostic in triple-negative, as well as estrogen receptor-positive, breast cancer cells. In our study, the conjugate was found to have enhanced activity in all mammalian cell lines tested in vitro. However, the conjugate was cytotoxic and did not induce G1 cell cycle arrest in breast cancer cells, suggesting its mechanism of action differs from the parent compound palbociclib. The study highlights the importance of investigating the mechanism of conjugates of near-infrared dyes to therapeutic compounds, as conjugation can potentially result in a change of mechanism or target, with an enhanced cytotoxic effect in this case.
Risk Analysis and Technology Assessment of Emerging (Gd,Ce)2O2S Multifunctional Nanoparticles: An Attempt for Early Safer-by-Design Approach
Authors: Nguyen Anh-Minh , Pradas del Real Ana Elena , Durupthy Olivier , Lanone Sophie , Chanéac Corinne , Carenco Sophie
Published: January 2022

Acceptability and relevance of nanoparticles in the society is greatly improved using a safer-by-design strategy. However, this is difficult to implement when too late in the development process or when nanoparticles are already on the market (e.g., TiO2). We employ this strategy for emerging nanoparticles of lanthanide oxysulfide of formula (Gd,Ce)2O2S, relevant for photocatalysis as well as for multimodal imaging, as the bandgap of the nanoparticles, related to their Ce content, impacts their ability to absorb visible light. As a first step, we investigated the production of reactive oxygen species (ROS) as a function of cerium content, in abiotic conditions and in vitro using murine macrophage RAW 264.7 cell line. We demonstrate that, at sub-lethal doses, Ce-containing oxysulfide nanoparticles are responsible for a higher ROS intracellular formation than cerium-free Gd2O2S nanoparticles, although no significant inflammatory response or oxidative stress was measured. Moreover, there was no significant loss of cerium as free cation from the nanoparticles, as evidenced by X-ray fluorescence mapping. Based on these results, we propose a risk analysis for lanthanide oxysulfide nanoparticles, leading to a technology assessment that fulfills the safer-by-design strategy.
Optical Mode Tuning of Monolayer Tungsten Diselenide (WSe2) by Integrating with One-Dimensional Photonic Crystal through Exciton–Photon Coupling
Authors: James Singh Konthoujam , Ciou Hao-Hsuan , Chang Ya-Hui , Lin Yen-Shou , Lin Hsiang-Ting , Tsai Po-Cheng , Lin Shih-Yen , Shih Min-Hsiung , Kuo Hao-Chung
Published: January 2022

Two-dimensional materials, such as transition metal dichalogenides (TMDs), are emerging materials for optoelectronic applications due to their exceptional light–matter interaction characteristics. At room temperature, the coupling of excitons in monolayer TMDs with light opens up promising possibilities for realistic electronics. Controlling light–matter interactions could open up new possibilities for a variety of applications, and it could become a primary focus for mainstream nanophotonics. In this paper, we show how coupling can be achieved between excitons in the tungsten diselenide (WSe2) monolayer with band-edge resonance of one-dimensional (1-D) photonic crystal at room temperature. We achieved a Rabi splitting of 25.0 meV for the coupled system, indicating that the excitons in WSe2 and photons in 1-D photonic crystal were coupled successfully. In addition to this, controlling circularly polarized (CP) states of light is also important for the development of various applications in displays, quantum communications, polarization-tunable photon source, etc. TMDs are excellent chiroptical materials for CP photon emitters because of their intrinsic circular polarized light emissions. In this paper, we also demonstrate that integration between the TMDs and photonic crystal could help to manipulate the circular dichroism and hence the CP light emissions by enhancing the light–mater interaction. The degree of polarization of WSe2 was significantly enhanced through the coupling between excitons in WSe2 and the PhC resonant cavity mode. This coupled system could be used as a platform for manipulating polarized light states, which might be useful in optical information technology, chip-scale biosensing and various opto-valleytronic devices based on 2-D materials.
Green-Synthesized Silver Nanoparticle–Assisted Radiofrequency Ablation for Improved Thermal Treatment Distribution
Authors: Ashikbayeva Zhannat , Aitkulov Arman , Atabaev Timur Sh. , Blanc Wilfried , Inglezakis Vassilis J. , Tosi Daniele
Published: January 2022

Thermal ablation therapy is known as an advantageous alternative to surgery allowing the treatment of multiple tumors located in hard-to-reach locations or treating patients with medical conditions that are not compatible with surgery. Appropriate heat propagation and precise control over the heat propagation is considered a weak point of thermal ablation therapy. In this work, silver nanoparticles (AgNPs) are used to improve the heat propagation properties during the thermal ablation procedure. Green-synthesized silver nanoparticles offer several attractive features, such as excellent thermal conductivity, biocompatibility, and antimicrobial activity. A distributed multiplexed fiber optic sensing system is used to monitor precisely the temperature change during nanoparticle-assisted radiofrequency ablation. An array of six MgO-based nanoparticles doped optical fibers spliced to single-mode fibers allowed us to obtain the two-dimensional thermal maps in a real time employing optical backscattering reflectometry at 2 mm resolution and 120 sensing points. The silver nanoparticles at 5, 10, and 20 mg/mL were employed to investigate their heating effects at several positions on the tissue regarding the active electrode. In addition, the pristine tissue and tissue treated with agarose solution were also tested for reference purposes. The results demonstrated that silver nanoparticles could increase the temperature during thermal therapies by propagating the heat. The highest temperature increase was obtained for 5 mg/mL silver nanoparticles introduced to the area close to the electrode with a 102% increase of the ablated area compared to the pristine tissue.
Design of Micro- and Nanoparticles: Self-Assembly and Application
Authors: Padnya Pavel , Stoikov Ivan
Published: January 2022

The modern world throws down an increasing number of challenges to humanity [...]
Rejection Mechanism of Ionic Solute Removal by Nanofiltration Membranes: An Overview
Authors: Suhalim Nur Syahirah , Kasim Norherdawati , Mahmoudi Ebrahim , Shamsudin Intan Juliana , Mohammad Abdul Wahab , Mohamed Zuki Fathiah , Jamari Nor Laili-Azua
Published: January 2022

The toxicity of heavy metals can cause water pollution and has harmful effects on human health and the environment. Various methods are used to overcome this pressing issue and each method has its own advantages and disadvantages. Membrane filtration technology such as nanofiltration (NF) produces high quality water and has a very small footprint, which results in lower energy usage. Nanofiltration is a membrane-based separation technique based on the reverse osmosis separation process developed in the 1980s. NF membranes have a pore size of 1 nm and molecular weight cut off (MWCO) of 300 to 500 Da. The properties of NF membranes are unique since the surface charge of the membranes is dependent on the functional groups of the membrane. The rejection mechanism of NF membrane is unique as it is a combination of various rejection mechanisms such as steric hindrance, electric exclusion, dielectric effect, and hydration mechanism. However, these mechanisms have not been studied in-depth due to their complexity. There are also many factors contributing to the rejection of NF membrane. Many junior researchers would face difficulty in studying NF membrane. Therefore, this paper is designed for researchers new to the field, and will briefly review the rejection mechanisms of NF membrane by both sieving and non-sieving separation processes. This mini-review aims to provide new researchers with a general understanding of the concept of the separation process of charged membranes.
Dietary Alaska Pollack Protein Induces Acute and Sustainable Skeletal Muscle Hypertrophy in Rats
Authors: Uchida Kenji , Fujitani Mina , Mizushige Takafumi , Kawabata Fuminori , Hayamizu Kohsuke , Uozumi Keisuke , Hara Yuma , Sawai Mariko , Uehigashi Ryota , Okada Shinji , Goto-Inoue Naoko , Morisasa Mizuki , Kishida Taro
Published: January 2022

Our previous studies suggested that Alaska pollack protein (APP) intake increases skeletal muscle mass and that it may cause a slow-to-fast shift in muscle fiber type in rats fed a high-fat diet after 56 days of feeding. In this study, we explored whether dietary APP induces acute and sustainable skeletal muscle hypertrophy in rats fed a normal-fat diet. Male 5-week-old Sprague–Dawley rats were divided into four groups and fed a purified ingredient-based high-fat diet or a purified ingredient-based normal-fat diet with casein or APP, containing the same amount of crude protein. Dietary APP significantly increased gastrocnemius muscle mass (105~110%) after 2, 7 days of feeding, regardless of dietary fat content. Rats were separated into two groups and fed a normal-fat diet with casein or APP. Dietary APP significantly increased gastrocnemius muscle mass (110%) after 56 days of feeding. Dietary APP significantly increased the cross-sectional area of the gastrocnemius skeletal muscle and collagen-rich connective tissue after 7 days of feeding. It decreased the gene expression of Mstn /Myostatin, Trim63/MuRF1, and Fbxo32/atrogin-1, but not other gene expression, such as serum IGF-1 after 7 days of feeding. No differences were observed between casein and APP groups with respect to the percentage of Type I, Type IIA, and Type IIX or IIB fibers, as determined by myosin ATPase staining after 7 days of feeding. In the similar experiment, the puromycin-labeled peptides were not different between dietary casein and APP after 2 days of feeding. These results demonstrate that APP induces acute and sustainable skeletal muscle hypertrophy in rats, regardless of dietary fat content. Dietary APP, as a daily protein source, may be an approach for maintaining or increasing muscle mass.
A Natural Plant Source-Tea Polyphenols, a Potential Drug for Improving Immunity and Combating Virus
Authors: Hong Mengyu , Cheng Lu , Liu Yanan , Wu Zufang , Zhang Peng , Zhang Xin
Published: January 2022

The coronavirus disease 2019 (COVID-19) is still in a global epidemic, which has profoundly affected people’s lives. Tea polyphenols (TP) has been reported to enhance the immunity of the body to COVID-19 and other viral infectious diseases. The inhibitory effect of TP on COVID-19 may be achieved through a series of mechanisms, including the inhibition of multiple viral targets, the blocking of cellular receptors, and the activation of transcription factors. Emerging evidence shows gastrointestinal tract is closely related to respiratory tract, therefore, the relationship between the state of the gut–lung axis microflora and immune homeostasis of the host needs further research. This article summarized that TP can improve the disorder of flora, reduce the occurrence of cytokine storm, improve immunity, and prevent COVID-19 infection. TP may be regarded as a potential and valuable source for the design of new antiviral drugs with high efficiency and low toxicity.
Taste of Fat and Obesity: Different Hypotheses and Our Point of View
Authors: Brondel Laurent , Quilliot Didier , Mouillot Thomas , Khan Naim Akhtar , Bastable Philip , Boggio Vincent , Leloup Corinne , Pénicaud Luc
Published: January 2022

Obesity results from a temporary or prolonged positive energy balance due to an alteration in the homeostatic feedback of energy balance. Food, with its discriminative and hedonic qualities, is a key element of reward-based energy intake. An alteration in the brain reward system for highly palatable energy-rich foods, comprised of fat and carbohydrates, could be one of the main factors involved in the development of obesity by increasing the attractiveness and consumption of fat-rich foods. This would induce, in turn, a decrease in the taste of fat. A better understanding of the altered reward system in obesity may open the door to a new era for the diagnosis, management and treatment of this disease.
Elovl2-Ablation Leads to Mitochondrial Membrane Fatty Acid Remodeling and Reduced Efficiency in Mouse Liver Mitochondria
Authors: Gómez Rodríguez Alexia , Talamonti Emanuela , Naudi Alba , Kalinovich Anastasia V. , Pauter Anna M. , Barja Gustavo , Bengtsson Tore , Jacobsson Anders , Pamplona Reinald , Shabalina Irina G.
Published: January 2022

The fatty acid elongase elongation of very long-chain fatty acids protein 2 (ELOVL2) controls the elongation of polyunsaturated fatty acids (PUFA) producing precursors for omega-3, docosahexaenoic acid (DHA), and omega-6, docosapentaenoic acid (DPAn-6) in vivo. Expectedly, Elovl2-ablation drastically reduced the DHA and DPAn-6 in liver mitochondrial membranes. Unexpectedly, however, total PUFAs levels decreased further than could be explained by Elovl2 ablation. The lipid peroxidation process was not involved in PUFAs reduction since malondialdehyde-lysine (MDAL) and other oxidative stress biomarkers were not enhanced. The content of mitochondrial respiratory chain proteins remained unchanged. Still, membrane remodeling was associated with the high voltage-dependent anion channel (VDAC) and adenine nucleotide translocase 2 (ANT2), a possible reflection of the increased demand on phospholipid transport to the mitochondria. Mitochondrial function was impaired despite preserved content of the respiratory chain proteins and the absence of oxidative damage. Oligomycin-insensitive oxygen consumption increased, and coefficients of respiratory control were reduced by 50%. The mitochondria became very sensitive to fatty acid-induced uncoupling and permeabilization, where ANT2 is involved. Mitochondrial volume and number of peroxisomes increased as revealed by transmission electron microscopy. In conclusion, the results imply that endogenous DHA production is vital for the normal function of mouse liver mitochondria and could be relevant not only for mice but also for human metabolism.
What Is the Relationship between Lifestyle and Frailty Status? Data from the Portuguese Multicentre Descriptive Study
Authors: Teixeira-Santos Luísa , Bobrowicz-Campos Elzbieta , Parola Vitor , Coelho Adriana , Gil Isabel , Almeida Maria de Lurdes , Apóstolo João Luís
Published: January 2022

This observational and descriptive study attempted, within the scope of the ModulEn Research Project, to determine associations between lifestyle-related variables and frailty involving 160 community-dwelling older adults aged between 65 and 80 years living in the Central Region of Portugal. Forty-three percent of the study participants were pre-frail and 18% were frail. More than 50% of the frail people had slight cognitive decline, and the frailty condition was more frequently observed in women. As the literature highlights, there is potential for greater reversibility in the pre-frailty condition. To contribute to this reversibility, it is necessary to resort to interventions that promote physical activity and cognitive stimulation, apply adequate eating habits, and/or encourage the adoption of an active and socially integrated lifestyle. A healthy lifestyle implies good sleep and eating habits, and correct metabolic control that allows for effective surveillance of dyslipidemia, diabetes, and blood pressure.
Increased Antibiotic Resistance in Children with Helicobacter pylori Infection: A Retrospective Study
Authors: Helmbold Luca , Ghebremedhin Beniam , Bellm Aliyah , Hopkins Marc A. , Wirth Stefan , Aydin Malik
Published: January 2022

Children with recurrent abdominal pain may be suffering from a Helicobacterpylori (HP) infection. The gold standard for confirming HP gastritis is histological evaluation and microbiological tests performed on specimens collected by esophagogastroduodenoscopy (EGD). The aim of this study was to analyze HP positive cultures and antibiograms with regard to clinical and histopathological correlates. The data of 124 subjects with frequent gastrointestinal symptoms who underwent an EGD were retrospectively collected and analyzed. The mean age of the patients was 13 ± 3.6 years. The most frequent complaints were epigastric pain (84%; n = 100/119) and dyspepsia (79%; n = 94/119). HP gastritis was diagnosed in 54% (n = 67). Interestingly, 40% (n = 49) of the isolates were resistant to at least one antibiotic: amoxicillin (20%; n = 10/49), clarithromycin (45%; n = 22/49), or metronidazole (59%; n = 29/49). Isolates were resistant to two or more antibiotics in 16% (n = 20) of cases. In conclusion, we revealed remarkably high resistance rates to amoxicillin, metronidazole, and clarithromycin in our cohort. The presence of antibiotic resistance to more than one antibiotic was substantially increased in our HP-infected patients and this may negatively affect eradication treatment.
Oligonucleotide Solid Nucleolipid Nanoparticles against Antibiotic Resistance of ESBL-Producing Bacteria
Authors: Nguyen Phuoc Vinh , Aubry Clémentine , Boudaoud Narimane , Gaubert Alexandra , Langlois Marie-Hélène , Marchivie Mathieu , Gaudin Karen , Arpin Corinne , Barthélémy Philippe , Kauss Tina
Published: January 2022

Antibiotic resistance has become a major issue in the global healthcare system, notably in the case of Gram-negative bacteria. Recent advances in technology with oligonucleotides have an enormous potential for tackling this problem, providing their efficient intrabacterial delivery. The current work aimed to apply this strategy by using a novel nanoformulation consisting of DOTAU, a nucleolipid carrier, in an attempt to simultaneously deliver antibiotic and anti-resistance oligonucleotides. Ceftriaxone, a third-generation cephalosporin, was formulated with DOTAU to form an ion pair, and was then nanoprecipitated. The obtained solid nanocapsules were characterized using FT-IR, XRD, HPLC, TEM and DLS techniques and further functionalized by the anti-resistance ONα sequence. To obtain an optimal anti-resistance activity and encapsulation yield, both the formulation protocol and the concentration of ONα were optimized. As a result, monodispersed negatively charged nanoparticles of CFX–DOTAU-ONα with a molar ratio of 10:24:1 were obtained. The minimum inhibitory concentration of these nanoparticles on the resistant Escherichia coli strain was significantly reduced (by 75%) in comparison with that of non-vectorized ONα. All aforementioned results reveal that our nanoformulation can be considered as an efficient and relevant strategy for oligonucleotide intrabacterial delivery in the fight against antibiotic resistance.
The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells
Authors: Han Geonhee , Kim Hyosuk , Kim Da Eun , Ahn Yeonjoo , Kim Joongsoo , Jang Ye Ji , Kim Kwangmeyung , Yang Yoosoo , Kim Sun Hwa
Published: January 2022

In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, and fibroblasts. The treatment with colostrum exosomes prevented the UV-induced generation of intracellular reactive oxygen species in epidermal keratinocytes. In UV-stimulated melanocytes, colostrum exosomes could also significantly reduce the production of the protective skin-darkening pigment melanin, which may help to reduce the risk of excessive melanin formation causing skin hyperpigmentation disorders. In the human dermal fibroblasts treated with colostrum exosomes, the expression of matrix metalloproteinases was suppressed, whereas increased cell proliferation was accompanied by enhanced production of collagen, a major extracellular matrix component of skin. Taken together, our findings indicate that bovine colostrum-derived exosomes having excellent structural and functional stability offer great potential as natural therapeutic agents to repair UV-irradiated skin aging and damage.
A Pilot Program to Teach Pharmacy Students Practical Skills to Navigate Drug Insurance Benefits
Authors: Masuda Camlyn , Huynh Tony , Wong Veronica , DeJong Colette , Tseng Chien-Wen
Published: January 2022

Pharmacists must be able to navigate prescription drug coverages to help providers and patients reduce out-of-pocket costs. Traditionally, curricula on drug insurance benefits rely on lectures and lack a practicum that offers students hands-on experience with determining formulary and cost-sharing information. An activity for pharmacy students to update a free public website that summarizes formularies and copayment requirements across major insurers was piloted. Pharmacy students were trained to locate online formularies and identify a drug’s coverage tier, step therapy, prior authorization, and cost-sharing during a 6-week experiential rotation. Students checked formularies from six insurance plans for 250-plus drugs across 15 health conditions. Graduates were surveyed (74% response rate) about the activities’ impact on their learning and ability to navigate drug benefits. Respondents rated the training as helpful in learning whether a drug was covered (100%), or required step therapy or prior authorization (100%). The majority of graduates reported being able to look up formulary coverage (90%), step therapy or prior authorization (90%), and copayment requirements (65%). Our innovative skills-based pilot activity was effective in teaching pharmacy students to navigate insurance formularies, which is essential for helping patients access medications.
Effect of Chitosan-24-Epibrassinolide Composite Coating on the Quality Attributes of Late-Harvested Pomegranate Fruit under Simulated Commercial Storage Conditions
Authors: Mwelase Sbulelo , Fawole Olaniyi Amos
Published: January 2022

This study evaluated the efficacy of chitosan (CH) functionalized with 24-epibrassinolide (EBR) coating in terms of preserving the postharvest quality of late-harvested pomegranate (cv. Wonderful) fruit. Late-harvested pomegranate fruit were immersed for 3 min in different surface treatment solutions—CH 1.5% (w/v), CH + 2 µM EBR, CH + 5 µM EBR, CH + 10 µM EBR and CH + 15 µM EBR—and distilled water was used as a control treatment. The fruit were air-dried and subjected to long storage duration at 5 °C with 85 ± 5 RH for 12 weeks. At 4-week sampling intervals, a batch of fruits was placed at 21 ± 2 °C and 65–70% RH for a further 3 d period to simulate retail conditions before measurements were taken. Fruit physiological responses, physico-chemical properties, phytochemical contents, antioxidant capacity and physiological disorders were monitored during storage. The results showed that the CH-EBR composite edible coatings significantly (p < 0.05) delayed degradative processes due to senescence. The CH-EBR treatments delayed colour, texture and total soluble solids (TSS) degradation and reduced weight loss, respiration, electrolyte leakage and spoilage compared to the control and CH treatment. The treatment effect was more noticeable on fruit treated with CH + 10 µM EBR, which exhibited lower weight loss (18.19%), respiration rate (7.72 mL CO2 kg−1 h−1), electrolyte leakage (27.54%) and decay (12.5%), and maintained higher texture (10.8 N) and TSS (17.67 °Brix) compared to the untreated fruit with respective values of 24.32%, 18.06 mL CO2 kg−1 h−1, 43.15%, 37.5%, 8.32 N and 17.03 °Brix. This was largely attributed to the significantly higher antioxidant content, including the ascorbic acid content, total phenol content, total anthocyanin content and DPPH (radical scavenging activity), of the coated fruit compared to the control fruit. Therefore, CH + 10 µM EBR treatment is recommended as a postharvest management strategy to improve the quality preservation of late-harvested pomegranate fruit during storage.
Higenamine in Plants as a Source of Unintentional Doping
Authors: Rangelov Kozhuharov Vanya , Ivanov Kalin , Ivanova Stanislava
Published: January 2022

Background: Higenamine is a β2 agonist of plant origin. The compound has been included in WADA’s prohibited list since 2017. Higenamine may be detected in different plants and many food supplements of natural origin. Methods: Our literature search was conducted through PubMed, Science Direct, Google Scholar, and Web of Science studies investigating the presence of higenamine in plants that are used in traditional folk medicine or included in food supplements. Our study aimed to assess the risk of adverse analytical findings caused by higenamine-containing plants. Results: Based on our literature search, Nelumbo nucifera, Tinospora crispa, Nandina domestica, Gnetum parvifolium, Asarum siebodii,Asarum heterotropoides, Aconitum carmichaelii, and Aristolochia brasiliensis are higenamine-containing plants. Based on data from Eastern folk medicine, these plants can provide numerous health benefits. Professional athletes likely ingest these plants without knowing that they contain higenamine; these herbs are used in treatments for different conditions and various foods/food supplements in addition to folk medicine. Conclusion: Athletes and their teams must be aware of the issues associated with the use of plant-based products. They should avoid consuming higenamine-containing plants during and outside of competition periods.
A New Year’s Message 2022
Authors: Yusa Shin-ichi
Published: January 2022

We greatly appreciate the contribution of Editorial Board Members, Guest Editors, reviewers, authors, and all related colleagues over the past year [...]
Micromechanical Modeling for Tensile Properties of Wood Plastic Composites: Use of Pruned Waste from Pecan Orchards as Sustainable Material for Reinforcement of Thermoplastic Composite
Authors: Díaz-Mendoza Juan Miguel , Valles-Rosales Delia J. , Park Young H. , Sabo Ronald C.
Published: January 2022

Wood plastic composites (WPCs) specimens containing high-density polyethylene (HDPE) and wood pruning waste were manufactured and evaluated for their mechanical properties. Pecan waste was used as an accessible and sustainable source in this study, and the effects of its particle size and concentration on WPC strengths were evaluated. Pecan waste was milled and sieved to various particle sizes, and testing samples were fabricated by mixing them in a twin-screw extruder and injection molding. A coupling agent was used to create a stable bond between the HDPE and wood. Both tensile modulus and strength were increased with an increasing pecan flour concentration up to about 60 weigh percent. A micromechanical model is proposed for predicting the mechanical properties of the wood flour/fiber reinforce composite. This model uses a correction factor of an elliptical of carried sizes and shapes. The preliminary results of the model have a high correlation with the experimental values of the composite in all mesh sizes.
Influence of Various Technologies on the Quality of Ultra-Wideband Antenna on a Polymeric Substrate
Authors: Lukacs Peter , Pietrikova Alena , Vehec Igor , Provazek Peter
Published: January 2022

The design, simulation, realization, and measurement of an ultra-wideband (UWB) antenna on a polymeric substrate have been realized. The UWB antenna was prepared using conventional technology, such as copper etching; inkjet printing, which is regarded as a modern and progressive nano-technology; and polymer thick-film technology in the context of screen-printing technology. The thick-film technology-based UWB antenna has a bandwidth of 3.8 GHz, with a central frequency of 9 GHz, and a frequency range of 6.6 to 10.4 GHz. In addition to a comparison of the technologies described, the results show that the mesh of the screens has a significant impact on the quality of the UWB antenna when utilizing polymeric screen-printing pastes. Last but not least, the eco-friendly combination of polyimide substrate and graphene-based screen-printing paste is thoroughly detailed. From 5 to 9.42 GHz, the graphene-based UWB antenna achieved a bandwidth of 4.42 GHz. The designed and realized UWB antenna well exceeds the Federal Communications Commission’s (FCC) standards for UWB antenna definition. The modification of the energy surface of the polyimide substrate by plasma treatment is also explained in this paper, in addition to the many types of screen-printing pastes and technologies. According to the findings, plasma treatment improved the bandwidth of UWB antennas to 5.45 GHz, and the combination of plasma treatment with graphene provides a suitable replacement for traditional etching technologies. The characteristics of graphene-based pastes can also be altered by plasma treatment in terms of their usability on flexible substrates.
Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin
Authors: Abdallah Marwa H. , Abu Lila Amr S. , Shawky Seham Mohammed , Almansour Khaled , Alshammari Farhan , Khafagy El-Sayed , Makram Tarek Saad
Published: January 2022

Current advancements in the research investigations focused at using natural products to generate novel dosage forms with a potential therapeutic impact. Silymarin is a natural product obtained from the herb Silybum marianum that has been shown to have remarkable hypoglycemic activity. Owing to the low enteral absorption, instability in stomach secretion, and poor solubility of Silymarin, it was better to be produced as a topical dosage form. A three-factor, three-level Box Behnken (33 BB) design was constructed to develop 15 formulations using three independent variables (phospholipid concentration, surfactant concentration, and sonication time) and two dependent variables (encapsulation efficiency and in vitro drug release). The optimized formula was added to HPMC gel and the resulting transfersomal gel was investigated for its characteristics, in vitro, ex vivo and hypoglycemic behaviors. The pH of the Silymarin-loaded transfersomal gel was 7.05, the spreadability was 55.35 mm, and the viscosity was 6.27 Pa. Furthermore, Silymarin loaded transfersomal gel had the greatest transdermal flux (92.41 µg/cm2·h), which was much greater than all other formulations. In vivo observations revealed that Silymarin loaded transfersomal gel significantly reduced blood glucose levels, compared to either Silymarin gel or oral Silymarin suspension. The findings show that the developed transfersomal gel could be an effective carrier for Silymarin transdermal delivery.
ABS/Silicon Dioxide Micro Particulate Composite from 3D Printing Polymeric Waste
Authors: Al-Mazrouei Noura , Ismail Ahmed , Ahmed Waleed , Al-Marzouqi Ali H.
Published: January 2022

In this paper, Acrylonitrile-Butadiene-Styrene matrix composites reinforced with Nano-silica dioxide particles were examined and prepared to study their mechanical properties. The composite sheets were pre-prepared using the hot extrusion process. Due to its wide characteristics, silica dioxide additions can strengthen the usability and mechanical features of composite thermoplastics and polymers. Furthermore, introducing silica dioxide as a filler in various attributes can help to maintain the smooth flow of sufficient powders, reduce caking, and manage viscoelasticity. Despite its advantages, 3D printing generates a significant amount of waste due to limited prints or destroyed support structures. ABS is an ideal material to use because it is a thermoplastic and amorphous polymer with outstanding thermal properties that is also applicable with the FFF (Fused Filament Fabrication) technique. The findings showed that increasing the silica dioxide content reduces the tensile strength to 22.4 MPa at 10 wt%. Toughness, ductility, and yield stress values of ABS/silica dioxide composites at 15 wt% increased, indicating that the composite material reinforced by the silica dioxide particles improved material characteristics. It is essential to consider the impact of recycling in polymer reinforcement with fillers. Furthermore, the improved mechanical qualities of the composite material encourages successful ABS recycling from 3D printing, as well as the possibility of reusing it in a similar application.
Recycled Poly(Ethylene Terephthalate) from Waste Textiles with Improved Thermal and Rheological Properties by Chain Extension
Authors: Wu Wen-Jun , Sun Xiao-Li , Chen Qinghua , Qian Qingrong
Published: January 2022

Annual production of textile fibers is continuing to rise and the substantial discharge of undegradable waste polyester fibers can cause serious environmental and even health problems. Thus, the recycling and reuse of recycled poly(ethylene terephthalate) from waste textiles (rPET-F) is highly desirable but still challenging. Here, five chain extenders with a different number of epoxy groups per molecules were used to blend with discarded PET fibers and improve its viscosity and quality loss in the recycling process. The molecule weight, thermal properties, rheological properties and macromolecular architecture of modified r-PET were investigated. It was found that all modified rPET-F samples show higher viscosities and better thermal properties. rPET-F modified by difunctional EXOP molecules show linear structure and improved rheological properties. rPET-F modified by polyfunctional commercial ADR and synthesized copolymers exhibit a long chain branched structure and better crystallization. This study reveals a deeper understanding of the chain extension and opens an avenue for the recycling of PET textiles.
Study on Curing Kinetics and the Mechanism of Ultrasonic Curing of an Epoxy Adhesive
Authors: Liu Zhaoyi , Wang Hui , Chen Yizhe , Kang Guodong , Hua Lin , Feng Jindong
Published: January 2022

Ultrasonic curing is an effective way to enhance the curing extent of composite material bonding in the aerospace industry. The non-thermal effect of ultrasonic has been revealed to improve curing efficiency. However, the mechanism of the ultrasonic non-thermal effect is still not clear. In this work, a variable activation energy model of ultrasonic curing was established by utilizing the iso-conversional method, including the activation energy of the thermal effect and activation energy of the non-thermal effect. The thermal effect caused by ultrasonic was accurately peeled off. An obvious decrease in activation energy was found from 54 kJ/mol in thermal curing to 38 kJ/mol in ultrasonic curing. The activation energy of the reaction system in ultrasonic curing was substituted into the modified Kamal autocatalytic equation, and the parameters of the ultrasonic curing kinetic model were estimated by means of an ALO algorithm. Further discussion based on in situ FTIR showed that the non-thermal effect of ultrasonic can affect the vibration strength, stability, and chemical bond energy of internal groups, but cannot cause the fracture of chemical bonds. Moreover, frontier molecular orbital analysis showed that the chemical reactivity of epoxy/amine molecules increased and the HOMO–LUMO energy gap decreased from 6.511 eV to 5.617 eV under the effect of ultrasonic.
Conception and Theoretical Study of a New Copolymer Based on MEH-PPV and P3HT: Enhancement of the Optoelectronic Properties for Organic Photovoltaic Cells
Authors: Ltayef Mariem , Almoneef Maha M. , Taouali Walid , Mbarek Mohamed , Alimi Kamel
Published: January 2022

A new copolymer has been studied, which is formed by Poly(2-methoxy-5-(2-ethyl-hexyloxy)-1,4-phenylene-vinylene) (MEH-PPV) and poly(3-hexylthiophene) (P3HT). The choice of these π-conjugated polymers was based on their semiconductor characters and their great applicability in electronic organic devices. The structure and vibrational and optoelectronic properties were simulated by calculations based on DFT, TD-DFT, and ZINDO. This material shows original and unique properties compared to the basic homopolymers. Thus, the obtained results reveal that this copolymer can be mixed with the (6,6)-phenyl C61 butyric acid methyl ester (PCBM) to give existence to a new composite that can be used as an active layer for an organic solar cell.
Field-Dependent Pollution Model under Polluted Environments for Outdoor Polymeric Insulators
Authors: Ahmed Rizwan , Abd Rahman Rahisham , Jamal Arshad , Salem Ali Ahmed , Saman Bander , Lau Kwan Yiew , Ghoneim Sherif S. M.
Published: January 2022

In-depth understanding of the pollution problems such as dry bands and the polymeric aging process requires better determination of electric field strength and its distribution over the polymeric surface. To determine the electric field distribution over the insulator surface, this research proposes utilizing a novel approach model based on nonlinear electrical characteristics derived from experimental results for polluted polymer insulators. A case study was carried out for a typical 11 kV polymeric insulator to underline the merits of this new modeling approach. The developments of the proposed pollution model and the subsequent computational works are described in detail. The study is divided into two main stages; laboratory measurements and computer simulations. In the first stage, layer conductance tests were carried out to develop nonlinear field-dependent conductivity for the pollution modeling. In the second part, equipotential and electric field distributions along the leakage were computed using the finite element method (FEM). Comparative field studies showed that the simulation using the proposed dynamic pollution model results in more detailed and realistic field profiles around insulators. This may be useful to predict the formation of dry bands and the initiation of electrical discharges on the polymeric surface.
Metronidazole Based Floating Bioadhesive Drug Delivery System for Potential Eradication of H. pylori: Preparation and In Vitro Characterization
Authors: Naseem Faiza , Shah Shefaat Ullah , Rashid Sheikh Abdur , Farid Arshad , Almehmadi Mazen , Alghamdi Saad
Published: January 2022

Metronidazole has the potential to produce local stomach specific action in order to treat Helicobacter pylori induced peptic ulcer disease. The current project executes the development of osmotically controlled bioadhesive metronidazole loaded effervescent floating tablets with optimized floating and swelling behavior. Direct compression technique was used to prepare the tablets. The designed formulations exhibited physico-chemical properties within acceptable optimum limits as per pharmacopeial requirements. The results of tablet floating studies revealed that all formulations, except F1 and F5, had good buoyancy characteristics (TFT > 12 h except F2 and F8 with TFT of 6 h). Formulation F2 containing guar gum in higher concentration with carbopol and formulation F8 containing guar gum in 50% decreased concentration in combination with HPMC and carbopol had enhanced FLT appreciably, with least TFT as compared to formulations F3, F4, and F6 (ANOVA; p ≤ 0.05). Formulation batches of F3, F4, and F6 exhibited appreciable FLT as well as TFT and were optimized formulations. Out of the above mentioned optimized batches, F4 and F6 formulations showed low FLT (4 and 5 s respectively). The results of the swelling study indicated a proportionate increase in the swelling index with increase in time. A significantly higher swelling ratio was found with formulation F6 and F4 compared with that of F7 and F8 (ANOVA; p ≤ 0.05). Additionally, the impact of pH change, agitational intensity, as well as increasing concentration of NaCl was investigated on drug release. It was observed that agitational intensity had no effect on drug release rate while increasing concentration of NaCl produced an increased drug release from the dosage form as compared to the drug release exhibited by the formulations in the absence of NaCl. Overall, this project could have valuable contribution in the fabrication of metronidazole loaded effervescent floating tablets. Gastro-retentive systems are expected to enhance local stomach specific action of anti H. pylori agents based on their buoyancy and swelling behavior.
The Effects of Cooling and Shrinkage on the Life of Polymer 3D Printed Injection Moulds
Authors: Bagalkot Anurag , Pons Dirk , Symons Digby , Clucas Don
Published: January 2022

3D Printed Injection Moulds (3DIM), commonly used for low volume production and prototyping purposes, are known to fail abruptly and have a comparatively shorter life than conventional moulds. Investigating the underlying critical factors affecting failure may help in reducing the risk of abrupt failures and possibly prolong the 3DIM tool life. A hypothesis that the cooling time of the Injection Moulding (IM) process is a critical factor for 3DIM tool failure has been proposed. The failure hypothesis has been validated by theoretical calculations, FEA simulations and experimental investigations. Experiments were performed using two different materials for the 3DIM tool (Visijet M3-X and Digital ABS) and an engineering thermoplastic (Lexan 943-A) as the moulding material. Results showed that cooling time was a critical factor on tool life and managing the thermal loading on a 3DIM tool could lead to increased tool life. The paper identifies cooling time as the critical factor affecting 3DIM tool life and presents a cooling regime that could possibly lead to prolonged tool life.
Soil Organic Carbon Dynamics in Response to Tillage Practices in the Steppe Zone of Southern Russia
Authors: Minnikova Tatiana , Mokrikov Gregory , Kazeev Kamil , Medvedeva Anna , Biryukova Olga , Keswani Chetan , Minkina Tatiana , Sushkova Svetlana , Elgendy Hadeer , Kolesnikov Sergey
Published: January 2022

Soil organic carbon (SOC) content is a vital indicator for soil health. The use of moldboard (traditional) plowing for many years had led to a prominent decline in the SOC and soil organic matter (SOM) in Southern Russia. Application of no-tillage (NT) is a sustainable alternative to conventional tillage (CT) as it offers an advantage for SOC store. The aim of the study was to assess soil organic carbon dynamics in response to tillage practices in the steppe zone of Southern Russia. The conservation of SOC under different tillage systems (CT and NT) was evaluated in comparison with the soils of the virgin soils (VS) in three different regions of the steppe zone of the Lower Don region (Southern of the European part of Russia). The SOC content under the conditions of CT was significantly lower than that in the VS and demonstrated an inclining trend when using NT technology. We estimate that the transition to NT over an area of 5.5 million hectares will lead to a significant reduction of carbon emissions into the atmosphere (by ~39 × 109 g C/year), thereby SOC deposition will be (~5.1 × 1012 g C) and high economic advantages will be reaped (with cost savings of up to 27%) in the Rostov region of Russia.
Review of Marginal Oil Resources in Highly Depleted Reservoirs
Authors: Pan Jun , Meng Yingfeng , Sun Ning , Liu Chang , Yang Sheng , Xu Jinze , Wu Wei , Li Ran , Chen Zhangxin
Published: January 2022

The term “marginal oil resource” refers to an oil reservoir that has hydrocarbon resource preservation but cannot meet the criteria of resources under the U.S Securities and Exchange Commission (SEC) standards. When oilfields step into their late life, most of their economic petroleum reserves have been well developed, and their focuses need to be switched to their intact marginal resources. In this paper, reservoir characteristics and key petrophysical properties of marginal oil resources are introduced to classify marginal oil resources into four types for identifying potential development opportunities. Primary recovery and its following development strategy are applied to fully utilizing their economic returns. Waterflooding, low salinity waterflooding (LSW) and enhanced oil recovery processes are reviewed to illustrate its potential uplift on oil production and application challenges such as higher clay content in marginal resources than in commercial reservoirs. An oilfield is presented as a case study to demonstrate the classification of marginal resources and illustrate successful economic development including learnings and challenges. This paper highlights the development potential of marginal resources and proposes a clear guidance for policy makers on how to tailor a development strategy supporting their economic development. This review could increase certainty on forecasting performance of marginal resources.
Unveiling the Temperature Influence on the Sorptive Behaviour of ZIF-8 Composite Materials Impregnated with [CnMIM][B(CN)4] Ionic Liquids
Authors: Ferreira Tiago J. , Esteves Laura M. , Esperança José M. S. S. , Esteves Isabel A. A. C.
Published: January 2022

Composite sorbent materials (IL@MOF) with a metal-organic framework (MOF) ZIF-8 and [B(CN)4]−-based ionic liquids (ILs) were produced for the first time. Characterization results indicate the successful IL impregnation and conservation of the ZIF-8 crystalline structure and morphology. The data collected from the nitrogen (N2) physisorption at 77 K suggest that these IL@ZIF-8 materials are nonporous as their textural properties, such as BET specific surface area and total pore volume, are negligible. However, CO2, CH4, and N2 adsorption/desorption measurements in the IL@ZIF-8 composites at 303 and 273 K contradict the N2 data at 77 K, given that the obtained isotherms are Type I, typical of (micro)porous materials. Their gas adsorption capacity and ultramicroporous volume are in the same order of magnitude as the pristine microporous ZIF-8. The case study [C6MIM][B(CN)4] IL revealed a high affinity to both CO2 and CH4. This compromised the selectivity performance of its respective composite when compared with pristine ZIF-8. This work highlights the importance of accurate experimental gas adsorption/desorption equilibrium measurements to characterize the adsorption uptake and the porous nature of adsorbent materials.