bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi Penerapan Rekam Medis Elektronik dengan Pendekatan Technology Acceptance Model di Rumah Sakit X di Kota Surabaya
Authors: Intansari Intansari , Rahmaniati Martya , Hapsari Dian Fajar
Published: June 2023

Rekam medis elektronik mempunyai peran yang cukup penting didalam penyelenggarakan pelayanan kesehatan di rumah sakit dimana rekam medis elektronik merupakan sumber data dan informasi kesehatan yang dapat digunakan dalam menilai baik buruknya pelayanan kesehatan. Rumah sakit X telah mengimplementasikan penggunaan rekam medis elektronik sejak tahun 2020 akan tetapi belum pernah dilakukan evaluasi terhadap penerapan rekam medis elektronik sehingga diperlukan upaya evaluasi yang formatif untuk melihat kualitas rekam medis elektronik dengan menggunakan Technology Acceptance Model yaitu menilai sebuah sistem berdasarkan dimensi kemudahan (ease of use) dan persepsi manfaat (usefulness) yang dapat mempengaruhi penggunaan sistem (attitude toward using) dan mengaplikasian sistem secara berkelanjutan (actual usage). Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan analisis uji korelasi bivariat untuk dapat menilai hubungan antara variabel yang diteliti. Hasil penelitian didapatkan bahwa terdapat hubungan positif yang signifikan (p-value 0.001, r = 0,717) antara keyakinan bahwa EMR dapat digunakan dengan mudah (perceived ease of use) dan manfaat dalam  performa kinerja dan produktivitas kinerja (perceived usefulness), Hubungan positif signifikan (p-value 0.001, r = 0,747) antara variabel EMR dapat memberikan manfaat dalam  performa kinerja dan produktivitas kinerja (perceived usefulness) dan sikap penggunaan EMR  (Attitude toward using).  Keyakinan bahwa EMR dapat digunakan dengan mudah (perceived ease of use) berpengaruh positif dan signifikan terhadap sikap penggunaan EMR (Attitude toward using) dengan nilai p-value 0.001, r = 0,7, serta hubungan yang signifikan nilai p-value 0.001, r = 0,717 antara keyakinan bahwa sikap penggunaan EMR (Attitude toward using) dan signifikan terhadap penggunakan EMR secara aktual (actual usage)
Tap-Water Security and Policy Implications in Hanoi, Vietnam
Authors: Phi Hoang Dinh , Van Giap Nguyen , Tuan Hoang Anh
Published: June 2023

This paper investigates tap-water securities using the management of non-traditional security (MNS) framework. The study found that tap-water in Hanoi is insecure due to uncertain upstream water sources, weak water quality monitoring, and poor wastewater drainage. Main challenges to tap-water security in Hanoi are ineffective management capacity of the local authorities as well as aging pipeline systems. Improvement in tap-water governance and collaborative co-governing is necessary. Privatization of tap-water utilities is not always effective to ensure tap water accessibilities to all residents. Finally, advanced water technologies are essential to achieving tap-water security in Hanoi.
Policy on Development of S&T Information in the Current Digital Transformation Context
Authors: Huu Buong Duong , Huy Thang Vu , Tien Duc Nguyen
Published: June 2023

The article analyzes the role of science and technology (S&T) information and development policies, the relationship between information and policy, and a number of macro policies on S&T information. From that, the study proposes policies for the development of S&T information in the context of the current digital transformation.
Identifying the Relationship of R&D and Production with Business Performance - A Theoretical Perspective
Authors: Anh Nguyen Thi Ngoc
Published: June 2023

Through an overview of relevant domestic and foreign scientific works on the relationship of research and development (R&D) and production in enterprises, the author focuses on the relationship between R&D and production, the correlation and the criteria used in evaluating the relationship between R&D and production. Most studies confirm that technology (including R&D) plays an important role in production activities and business results. R&D is highly important for technology firms, particularly high-tech enterprises, in terms of development and competition. This role of R&D is emphasized throughout the study review; yet, in different types of companies, the demonstration of the link between R&D and production and enterprise success remains difficult and unresolved.
Greenhouse and open-field Tomato farming. A comparison through yield and growth parameters investigated in Dar es Salaam
Authors: Chacha James , Thirumalai Murugan , Mathias Nafue , Idawa Obeid , Chilwea Josephine , Kilamba Concheska , Hussy Bertha , Rajendran Kalidoss , Ishaq Haaniya
Published: June 2023

Growth in terms of yield and growth parameters of tomato plants grown in greenhouse and open fields was investigated in the present study. Growth in terms of height results showed that the p-value was found to be 0.025054. The significant differences were observed in tomato crops grown in two systems at p
Museum communication: the current state of research and challenges for linguistics
Authors: Czachur Waldemar , Mikołajczyk Beata , Opiłowski Roman
Published: June 2023

This paper deals with communication processes taking place in the museum, collectively referred to as museum communication, from the point of view of contemporary linguistics. Based on previous research, museum communication is defined as a kind of interplay of multiple communicative practices multimodally organised within a museum and activated in communication with the museum’s external partners. Linguistics has so far looked at museum communication mainly in terms of language use, including other semiotic systems, with particular attention to the related communicative strategies and practices, genres of texts, and their functions, both in internal and external communication. However, the paper argues that the scope of tools used to study museum communication should be broadened. The key determinants of museum communication include multimodality, multisensoriality, hybridity, and digitality. The paper provides a review of linguistic models of analysis with a variety of tools and solutions that have been developed for the study of multimodal texts with similar attributes in different communicative fields. The review is thenused to develop a catalogue of linguistic analytical categories that can be applied to detailed analyses of particular aspects of museum communication.
A szellemi tőkeberuházások és vagyon szerepe a versenyképesség javításában
Authors: Csath Magdolna
Published: June 2023

Az esszében a versenyképesség javíthatóságának a szellemi vagyon és tőkeberuházások kapcsolatára visszavezethető feltételeit vizsgáljuk nemzetközi szakirodalomra és adatokra támaszkodva Magyarország esetén. Kitérünk a versenyképességet megalapozó termelékenység és a szellemi tőkeberuházások kapcsolatára is. Amellett érvelünk, hogy bár az idézett fogalmak értelmezésével kapcsolatban nincs egységesen elfogadott szakmai konszenzus, valamint további elemzésekre és modellezésre is szükség lenne, már a bemutatott összefüggések is valószínűsítik, hogy a magyar gazdaság termelékenységének és versenyképességének javulásához hozzájárulna a magasabb szellemi vagyonérték és tőkeberuházás szint. Egyrészt azért, mert javítaná a tárgyi beruházások általános működési hatékonyságát, másrészt azért, mert támogatná a versenyképességi szintlépés legfontosabb feltételét, a tudásgazdaságba való átmenetét.
Az elsőlakás-vásárlók hitelfelvételi lehetőségeinek potenciális javítása az adósságfék-szabályok keretében
Authors: Grosz Gabriella , Izsák Gábor , Palicz Alexandr Maxim , Szász Katinka
Published: June 2023

Az elmúlt évek dinamikus ingatlanár-emelkedése nyomán 2014-hez képest a lakásárak és így a jelzáloghitel-felvételhez minimálisan szükséges önerő összege több mint háromszorosára emelkedett 2022-re. Ez a jellemzően fiatal, legfeljebb 35 éves első lakásukat vásárlók hitelfelvételi lehetőségének romlásához vezetett, főként a családtámogatási programok igénybevételére nem jogosult ügyfelek körében. Jelen tanulmányunkban részletesen áttekintjük az adósságfék-keretrendszer elsőlakás-vásárlókra gyakorolt potenciális mellékhatásait. Ezeket az ügyfeleket az adósságfék-szabályok a hitelkockázatukhoz képest súlyosabban érinthetik, negatív másodkörös hatásokat generálva, emiatt – a nemzetközi gyakorlattal összhangban – esetükben kedvezményes korlátok alkalmazása merülhet fel, elsősorban az önerő mértékére vonatkozóan. Egy ilyen döntésnél azonban fontos figyelemmel lenni a lakás- és hitelpiaci kockázatok alakulására és a makrogazdasági környezetre is.
Enhancement of Teachers’ Knowledge through Neuroscience Constituents for Student -Teaching and Learning: A Systematic Review
Authors: Abhishek Kumar
Published: June 2023

As an emerging and developing field in education, educational neuroscience has much to offer in terms of preparing and promoting teachers, and this article aims to provide in Enhancing the Teachers’ Knowledge through Neuroscience Constituents to benefit Student -Teaching and Learning. Sixty-five pieces of literature from 1962 to 2022 in the fields ‘abstract’, ‘topic’ and ‘title’ have been integrated. Articles were reviewed and synthesised by using the content analysis technique under two overarching themes: First, Neuroeducation informs student teaching and learning, and Second Fundamental Structure and Functions of the Brain. Based on the findings, It was also clear that the content knowledge of Neuroscience holds strong conceptual positioning that might strengthen the Teacher’s knowledge, Student -Teaching and Learning process. However, reaching a consensus about the inculcation of discipline in teacher education programmes is not possible in the short span. Therefore, article made a small attempt to bridge the gap.
Academic Achievement and Levels of Immediate and Delayed Recall among High School Students of Mizoram
Authors: Lalnunpuii  , Zokaitluangi
Published: June 2023

Cognitive psychology is the scientific study of mental processes including memory which is a numerous biological device. The present study examines the levels of immediate and delayed Recall memory among 320 High School Students, comprised of equal representation of high and low academic achievers to find any significant difference between high and low academic achievers using the PGI-Memory Scale constructed by Pershad and Wig (1977 & 1988). Results highlighted a significant difference between a high academic achiever and low academic achievers on immediate and delayed recall, positive correlation between the immediate recall and delayed recall; and the effect of level of academic achievement effect immediate and delay recall memory. The findings suggested that the importance of immediate and delayed recall memory impact on children’s educational resulting in academic achievement.
Ex vivo digital comparison of four impression techniques using an industrial laser scanner
Authors:   Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Jász Bálint , Jász Máté ,   Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Körmendi Szandra ,   Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Joós-Kovács Gellért ,   Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Vecsei Bálint ,   Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Hermann Péter ,   Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Borbély Judit ,   Department of Prosthodontics, Faculty of Dentistry, Semmelweis University
Published: June 2023

Introduction: The aim of the study was to compare different impression techniques used for fixed prosthodontics. Methodology: A master cast with prepared abutments was created from polymethyl-methacrylate (PMMA). A high-resolution industrial scanner was used to create a virtual reference model. Four different impressions were made, three with polyvinyl-siloxane (PVS) (n = 10 for each): one-step putty-wash (1SPW), two-step putty-wash prepared with an escape channel (2SPW-Ch), two-step putty-wash with a polyethylene spacer foil (2SPW-Fo), and one with polyether monophasic technique (MP) from the PMMA model and digitized with an industrial scanner. The stereolithographic (STL) files of the impressions (n = 40) were exported. Each file was compared to the reference using the Geomagic Verify software. Six points were assigned to enable virtual calliper measurement of tooth diameters and distances of varying sizes within the arch. Results: In the case of die diameters, the deviation from the mould ranged from 31.84 to 180.64 μm. At the stump diameter level, the MP and 1SPW techniques showed significantly more minor differences than the 2SPW-Ch, and the MP was significantly more accurate than the 2SPW-Fo. At medium distance, the deviation ranged from 42.74 to 136.47 μm. Therefore, MP was found to be significantly more accurate than 2SPW-Ch. When examining the long distance, the difference was between 162.62 and 348.85 μm. The MP and 1SPW impression techniques proved significantly more accurate than the 2SPW-Ch technique for long distances. Conclusions: With both simultaneous techniques, significantly more true results were achieved than with the two-step techniques. Keywords: Dental Impression Technique; Scanning of the Impression; Monophase; One-Step Putty-Wash; Two-Step Putty-Wash.
Orthodontics and Periodontology Combined treatments and clinical synergies
Authors:   DMD, PhD Student  Holistic Dental & Medical Institute  of Bucharest, Constantinescu Florin-Eugen
Published: June 2023

Books Review
BRASIL, O CORPO NEGRO FEMININO E INCONSCIENTE COLETIVO
Authors: Sobrinho Aline , Wagner Patrick
Published: June 2023

A experiência coletiva emerge, muitas vezes, influenciada por padrões herdados da humanidade através do inconsciente coletivo e dos arquétipos. Pensando o processo colonial no Brasil e a estrutura social vigente, articulada ao longo dos anos, faz-se importante observar os efeitos das experiências socio-históricas que se refletem na contemporaneidade. Assim, o presente estudo buscou compreender, por meio de narrativas de mulheres negras brasileiras, o sentido da objetificação dos seus corpos. Para tanto, esse trabalho foi elaborado a partir de uma revisão bibliográfica sobre o tema e entrevistas semiestruturadas com mulheres negras. Com isso, pôde-se notar, sobretudo por meio dos relatos, a influência dos padrões de beleza atuais na autopercepção e na relação com o próprio corpo, a consciência da ação do racismo na sociedade, vivências de hiperssexualização desde a infância, a interferência do meio social na autoestima e, além disso, a indicação do autoconhecimento e da educação como caminhos para a promoção do processo de individuação e das mudanças de perspectiva. Logo, o desvelamento de diferentes sentidos derivados das experiências propiciaram múltiplas percepções sobre a objetificação. A relação com o próprio corpo, mesmo em diferentes vivências, revelou influências provenientes da estrutura socio-histórica brasileira.
Depression and anxiety among persons with type II diabetes mellitus and hypertension; A cross-sectional analytical study in the rural field practice area of a tertiary care center in Puducherry
Authors: Salim Simi , Saya Ganesh Kumar , Kattimani Shivanand , Kar Sitanshu Sekhar
Published: June 2023

Objectives:

To determine the proportion of depression and anxiety disorders; their association with sociodemographic, NCD-related factors and Quality of Life among persons with type II Diabetes Mellitus or Hypertension at a rural health center in Puducherry.

Materials and Methods:

This facility-based cross-sectional analytical study recruited 692 participants from May 2020 to September 2021. A structured questionnaire collected sociodemographic and NCD-related history; The Hospital Anxiety and Depression Scale (HADS) and The World Health Organization quality of life (WHOQOL) - BREF questionnaires for depression, anxiety and QOL assessment, respectively. Independent variables were assessed for relationship with depression and anxiety using univariate analysis. Multivariable logistic regression analysis was done to determine the predictors of depression and anxiety.

Results:

Nearly 17.8% (95% confidence interval [CI] - 13.8%–22.4%) had depression and 12.7% (95% CI - 9.5–16.7%) had anxiety. Age (adjusted odds ratio [aOR] - 0.97; 95% CI - 0.95–0.99), depression/anxiety disorders family history (aOR - 2.58; 95% CI - 1.26–5.26), overall QOL score reduction (aOR - 0.76; 95% CI - 0.60–0.97), and social domain score reduction (aOR - 0.98; 95% CI - 0.97–0.99) were the significant predictors of depression. No formal education (aOR - 10.84; 95% CI - 4.54–25.86), being homemaker (aOR - 3.49; 95% CI - 1.29–9.42), no DM/HTN family history (aOR - 1.51; 95% CI - 0.66–1.54), psychological domain score reduction (aOR - 0.97; 95% CI - 0.95–0.99) and environmental domain score reduction (aOR - 0.96; 95% CI - 0.94–0.98) were significant predictors of anxiety.

Conclusion:

Nearly one-fifth had depression and more than one-tenth had anxiety among the participants. A fair number of persons with HTN/DM have higher anxiety and depressive scores and most domains had a poor QOL score with depression alone having associated with a depression/anxiety family history.
Application of Linear Polyacrylamide (LPA) Matrix in Cotton Chromatin Immunoprecipitation to Increase Sheared DNA Isolation Efficiency
Authors: AVCI Murat Kemal , TEZCAN Erdem , AVCI Safiye , CAMCI Haluk
Published: June 2023

Linear Polyacrylamide (LPA) is one of the polymers used as a yield-enhancing agent in DNA isolation of short and small molecular weight DNA molecules. The Chromatin immunoprecipitation (ChIP) method is widely used to elucidate DNA-Protein interactions. In ChIP, which consists of many successive steps, it is an important problem to experience losses due to the small size of the DNA fragments during the re-isolation of the sheared DNA fragments. In this study, the effect of using LPA matrix on the isolation of small molecular weight DNA fragments with higher efficiency in the ChIP method applied to cotton plant, which is a eukaryotic organism with high commercial value in our country and in the world, was investigated. Here, the ChIP method was adapted and applied till the DNA fragmentation process by ultrasonication and the isolation of the fragmented DNA molecules. In statistical analyzes, the concentrations of DNA isolates used at the beginning of the ChIP experiment and the DNA molecules mechanically fragmented by ultrasonication, measured by the Nanodrop, were compared in ng/µl. Experimental and statistical analyzes showed that LPA application increased DNA isolation efficiency by 0.59 times. Based on these data, it has been proven that using LPA in ChIP method with cotton will directly affect the success of the experiment and contribute to get much more efficient results. This study is unique in that it focuses on improving the yield of sheared DNA isolation in direct cotton plant-specific ChIP application.
Some Physicochemical Characteristics of Denizli Thyme (Origanum onites) Honey
Authors: UÇAK KOÇ Aytül , ATAKAN Yusuf , KÜÇÜKER Hüseyin , KÜÇÜKER Hüdai
Published: June 2023

In this study, the number of beekeepers staying within the borders of Denizli province, which is one of the important accommodation centers of wandering beekeepers with its large thyme fields, and their accommodation places were determined and some information about thyme honey was obtained. Especially in Gözler, Uzunpınar, Belenardıç and Güzelpınar neighborhoods of Pamukkale district and Yağcılar neighborhoods of Güney district, thyme fields are dense and approximately 24 thousand beekeepers stayed in 2021. Some physicochemical analyzes were carried out, for example, 9 honeys in 2021 and 6 honeys in 2022, which were collected in July when the Denizli thyme honey produced in these areas was harvested. First, pollen analysis was made in honey samples, and it was determined that it was thyme honey. Then, proline, diastase activity (DA), moisture, electrical conductivity (EC), pH, free acidity (FA), HMF, fructose (F), glucose (G), total phenolic content (TPC) was determined in 15 honey samples. Average amount of proline in thyme honey samples in 2021 and 2022, respectively; 663.5 and 708.9 mg/kg, DA 10.9 and 11.75; humidity rates 17.1% and 17.3%; EC 560 and 540 µS cm-1 ; pH 3.8 and 3.8; FA; 26.4 and 28.8 meq.kg-1 ; HMF, 9.5 and 12.4 mg/kg; F+G 69.6% and 69%; F/G was determined as 1.13 and 1.10, and the TPC was determined as 75.9 mg GAE/100g. In the future, it will be possible to reveal the descriptive features of Denizli thyme honey from other honeys by conducting more comprehensive and advanced analyzes.
Biotechnology – A Tool to Transform Givaudan’s Fragrance Ingredients Palette
Authors: Eichhorn Eric , Baumgartner Corinne , Biermann Marc
Published: June 2023

To support perfumers in their creation of olfactive signatures resulting in unique and instantly recognizable perfumes, there is a constant demand for the development of new odorant molecules and of novel processes for their production. Increasing the sustainability of both the molecules and the processes is a crucial activity at Givaudan. Biocatalysis has the potential to positively influence metrics applied at Givaudan that drive and measure our ambition to innovate responsibly, which is summarized in the FiveCarbon Path™. It targets an increased use of renewable carbon, carbon efficiency in synthesis, and the production of powerful and biodegradable odorant molecules while maximizing the use of upcycled carbon available from waste and side streams. This review illustrates with some examples how enzymes selected from the oxidoreductase and isomerase enzyme classes are applied at Givaudan for the preparation of odorant molecules both at laboratory and industrial scale.
Nanospray desorption electrospray ionization (nano-DESI) mass spectrometry imaging with high ion mobility resolution
Authors: Jiang Lixue , Hernly Emerson , Hu Hang , Hilger Ryan , Neuweger Heiko , Yang Manxi , Laskin Julia
Published: June 2023

Untargeted separation of isomeric and isobaric species in mass spectrometry imaging (MSI) is challenging. The combination of ion mobility spectrometry (IMS) with MSI has emerged as an effective strategy for differentiating isomeric and isobaric species, which substantially enhances the molecular coverage and specificity of MSI experiments. In this study, we have implemented nanospray desorption electrospray ionization (nano-DESI) MSI on a trapped ion mobility spectrometry (TIMS) mass spectrometer. A new nano-DESI source was constructed, and a specially designed inlet extension was fabricated to accommodate the new source. The nano-DESI-TIMS-MSI platform was evaluated by imaging mouse brain tissue sections. We achieved high ion mobility resolution by utilizing three narrow mobility scan windows that cover the majority of the lipid molecules. Notably, the mobility resolution reaching up to 300 in this study is much higher than the resolution obtained in our previous study using drift tube IMS. High-resolution TIMS successfully separated lipid isomers and isobars revealing their distinct localizations in tissue samples. Our results further demonstrate the power of high mobility resolution IMS for unraveling the complexity of biomolecular mixtures analyzed in MSI experiments.
Unraveling Eumelanin Radical Formation by Nanodiamond Optical Relaxometry in a Living Cell
Authors: Lu Qi , Vosberg Berlind , Wang Zhenyu , Balasubramanian Priyadharshini , Sow Maabur , Volkert Carla , Gonzalez Brouwer Raul , Lieberwirth Ingo , Graf Robert , Jelezko Fedor , Plenio Martin , Wu Yingke , Weil Tanja
Published: June 2023

Defect centers in nanodiamond allow the detection of tiny magnetic fields in their direct surrounding, which makes them an emerging tool for nanoscale sensing applications. The abundant pigment eumelanin plays a major role in biology and material science. We present the first time tracking of the comproportionation reaction in eumelanin by detecting and quantifying semiquinone radicals via the nitrogen-vacancy colour centre as single atom detector. A thin layer of eumelanin is polymerized on the surface of NDs and depending on the environmental conditions, such as pH, near infrared and ultraviolet light irradiation, the radicals undergo maintenance, formation, or disappearance in-situ. By combining experiments and theoretical simulations, we were able to quantify the local number and kinetics of free radicals in the eumelanin layer. Next, the nanodiamond sensor was transported into cells in endosomal vesicles and the number of radicals within the eumelanin layer was also determined. The new quantum sensor could provide valuable insights into the chemistry of eumelanin, which could shine light on eumelanin and melanin-related diseases.
Could Acinetobacter baumannii Lol-abaucin docking be improved?
Authors: coll julio
Published: June 2023

To explore alternative abaucin antibiotics predicting nanomolar affinities against Acinetobacter baumannii, thousands of virtual abaucin-derived molecules were randomly generated and selected. For this, alphafold-modeled A.baumannii lipoprotein outer membrane localization (Lol) complex proteins were targeted by DataWarrior "build evolutionary libraries". Abaucin-children libraries were generated from the abaucin-parent iteratively selecting those predicting higher affinities to the most probable A.baumannii LolCE docking-cavity. To improve accuracies, ~4000 abaucin-children docking-scores were consensed with those from AutoDockVina. The resulting laydown table provided with filter sliders would allow user-criteria to be applied. One example explored candidates predicting both higher nanomolar affinities to A.baumannii LolCE (to favor putative antibiotics) and lower affinities to E.coli LolCE (to favor narrow-bacterial spectrum hits). Despite being highly hypothetical, some of these abaucin-derived chemotypes may constitute another step towards exploring possible improvements for anti-A.baumannii antibiotics.
Influences of Large Pendent Groups to Chain Conformation and Electrical Energy Loss at High Frequency of Polyimides through All-Atomic Molecular Simulation
Authors: Lin Tzu-Jen
Published: June 2023

Polyimide is a potential material for high-performance printed circuit board materials because of its excellent thermal and mechanical properties and chemical stabilities. Flexible printed circuit boards must have a low static dielectric constant and loss (low-Dk/Df) to reduce signal loss in high-speed communication devices. Engineering the molecular structure of polyimides with large pendant groups is a strategy to reduce their dielectric constant. However, there is no systematic study on how the large pendant groups influence electrical energy loss. We integrated all-atomic molecular dynamics and semiempirical quantum mechanical calculations to examine the influence of pendant groups on polymer chain conformation. In addition, we proposed an efficient way to determine electrical energy loss at high frequencies. We analyzed the radius of gyration, relative shape anisotropy, dipole moment, and degree of polarization of selected PI polymer chains, TPAHF, TmBPHF, TpBPHF, MPDA, TriPMPDA, m-PDA, and m-TFPDA. The simulation results show that anisotropy perpendicular to the chain direction and chain rigidity of polyimides with large pendant groups correlate more to electrical energy loss than their dipole moment magnitudes. Polyimides with anisotropic pendant groups and significant chain rigidity reduce electrical energy loss. Polyimides with soft and isotropic polymer chains easily have local structural changes by external electric fields, leading to electrical energy loss.
Which boronic acids are used most frequently for synthesis of bioactive molecules ?
Authors: Ertl Peter , Altmann Eva , Racine Sophie , Decoret Odile
Published: June 2023

Boronic acids are essential building blocks used for the synthesis of bioactive molecules, the generation of chemical libraries and the exploration of structure-activity relationships. As a result, more than ten thousand boronic acids are commercially available. Medicinal chemists are therefore facing a challenge; which of them should they select to maximize information obtained by the synthesis of new target molecules. The present article aims to help them to make the right choices. The boronic acids used frequently in the synthesis of bioactive molecules were identified by mining several large molecular and reaction databases and their properties were analyzed. Based on the results a diverse set of boronic acids covering well the bioactive chemical space was selected and is suggested as a basis for library design for the efficient exploration of structure-activity relationships. A Boronic Acid Navigator web tool which helps chemists to make their own selection is also made available at https://bit.ly/boronics.
CASNet: Learning Complete Active Space Orbitals using Message Passing Neural Networks
Authors: van Workum Ruard , Malhado Joao , Marquetand Philipp
Published: June 2023

Machine learning has demonstrated success in predicting molecular orbitals obtained from common single-configurational quantum chemistry methods, such as Hartree-Fock or Kohn-Sham Density Functional Theory. In this work, we present an extension of this supervised learning framework to multi-configurational quantum chemistry methods and compare different approaches for learning excited-state molecular wavefunctions. More specifically, by utilizing recent advances in message passing neural networks designed for learning molecular properties, we investigate the learning of molecular orbitals from State-Averaged Complete Active Space Self Consistent Field as a means of speeding up the corresponding calculations. We demonstrate the advantage of this general approach, referred to as \textit{CASNet}, over traditional orbital initialization techniques on different datasets of pentafulvene and evaluate its practical utility.
A multiplexing activity-based protein profiling platform for dissection of a native bacterial xyloglucan-degrading system
Authors: McGregor Nicholas , de Boer Casper , Foucart Quentin , Beenakker Thomas , Offen Wendy , Codee Jeroen , Willems Lianne , Overkleeft Herman , Davies Gideon
Published: June 2023

Bacteria and yeasts grow on biomass polysaccharides by expressing and excreting a complex array of glycoside hydrolase (GH) enzymes. Identification and annotation of such GH pools, which are valuable commodities for sustainable energy and chemistries, by conventional means (genomics, proteomics) is complicated, as primary sequence or secondary structure alignment with known active enzymes is not always predictive for new ones. Here we report a “low-tech”, easy-to-use and sensitive, multiplexing activity-based protein profiling platform to characterize the xyloglucan-degrading GH system excreted by the soil saprophyte, Cellvibrio japonicus when grown on xyloglucan. A suite of activity-based probes bearing orthogonal fluorophores allows for the visualization of accessory exo-acting glycosidases, which are then identified using biotin-bearing probes. Substrate specificity of xyloglucanases is directly revealed by imbuing xyloglucan structural elements into bespoke activity-based probes. Our ABPP platform provides a highly useful tool to dissect xyloglucan-degrading systems from various sources and to rapidly select potentially useful ones. The observed specificity of the probes moreover bodes well for the study of other biomass polysaccharide degrading systems, by modelling probe structures to those of desired substrates.
Building an ab initio solvated DNA model using Euclidean neural networks
Authors: Lee Alex , Rackers Joshua , Pathak Shivesh , Bricker William
Published: June 2023

Accurately modeling large biomolecules such as DNA from first principles is fundamentally challenging due to the steep computational scaling of ab initio quantum chemistry methods. This limitation becomes even more prominent when modeling biomolecules in solution due to the need to include large numbers of solvent molecules. We present a machine learning electron density model based on a Euclidean neural network framework to model explicitly solvated double-stranded DNA. The neural network framework has a built-in understanding of equivariance, allowing the model to learn 3D structural information efficiently by exploiting the properties of Euclidean symmetry. By training the machine learning model using molecular fragments that sample the key DNA and solvent interactions, we show that the model predicts electron densities of arbitrary systems of solvated DNA accurately, resolves polarization effects that are neglected by classical force fields, and captures the physics of the DNA-solvent interaction at the ab initio level.
VLSI implementation of Kogge-Stone Adder for low-power applications
Authors: Eppili Jaya , B. Sai Sri , P. Akshay Kumar , O. Hem Kumar , Sunil D. , Rajesh R.
Published: June 2023

The adder is a vital part of the Central Processing Unit (CPU) that can perform computational operations. It is used in digital components, mainly in the design of integrated circuits. Recent decades have seen a sharp rise in demand for mobile electronics, which has increased the need for highly efficient Very Large-Scale Integration (VLSI) structures. All operations must be computed using low-power, space-efficient designs that run faster. The Kogge-Stone adder (KSA) is an extension of the carry look-ahead adder which is used for performing fast addition in high-performance computing systems. This study compares the latency, space, and energy used by the Kogge-Stone Adder after development and implementation in Xilinx Vivado using Verilog to those of the Ripple Carry Adder (RCA) and Carry Lookahead Adder (CLA). The results show that the KSA has a decrease in power consumption as well as improvements in high speed and area compaction when compared to the RCA and CLA.
Design and verification of memory by using UVM methodology
Authors: Sonali Sangode , Chandrahas Sahu
Published: June 2023

The design and verification of memory using the Universal Verification Methodology (UVM) methodology is discussed in this research. The advanced verification architecture uses a minimum number of macros, methods, and classes, and it provides high reusability for UVM tests. It makes use of the common attributes between different memory controllers to generate a common and configurable scoreboard, sequences, stimulus, different UVM components, and test cases. The memory controller provides a constructive control of data between the processor and memory. It provides modern structure and building blocks to work with codes, and it allows a dynamic approach. Simulation results show that the designed controller has a good performance and meets all the system specifications.
Design of rectangular microstrip patch antenna with E-slot
Authors: Pragati Tiwari , Akshaya Mishra , Madhavi Tripathi , Shreya Dubey
Published: June 2023

The integration of an E-slot within the conventional microstrip patch antenna structure offers improved radiation characteristics and bandwidth. This research presents the design and analysis of a rectangular microstrip patch antenna with an E-slot. The proposed antenna is designed to operate at a specific frequency in the microwave range. The design process involves determining the dimensions of the rectangular patch, feedline, and E-slot to achieve the desired resonance frequency. The simulation and optimization are carried out using electromagnetic simulation software, considering the dielectric substrate properties and other relevant parameters. The E-slot is strategically placed within the patch structure to enhance the antenna's performance. It acts as an additional resonating element, contributing to increased bandwidth and improved radiation characteristics, such as gain and directivity. The integration of the E-slot modifies the current distribution on the patch, resulting in enhanced radiation properties. The performance of the proposed antenna is evaluated through various parameters, including return loss, radiation pattern, and bandwidth. Overall, the rectangular microstrip patch antenna with an E-slot presents a promising solution for achieving enhanced performance in terms of bandwidth and radiation characteristics. The proposed design opens up possibilities for further advancements in microstrip antenna technology, facilitating the development of an efficient and compact antenna structure for modern wireless applications.
Impotencia reflexiva en la distopía adolescente contemporánea
Authors: Rey Segovia Ana Clara
Published: June 2023

El auge de la distopía en el audiovisual contemporáneo coincide, en buena parte, con el ciclo de protestas inaugurado por movimientos como Occupy en los Estados Unidos o el 15M español, conformados, mayoritariamente, por jóvenes. Esta coincidencia no es casual: el género distópico ha sido tradicionalmente asociado a una forma de denuncia, enfocada a promover la reflexión crítica y transformadora sobre la realidad. No obstante, la mirada atenta a algunos de los filmes distópicos más populares entre el público juvenil demostrará que los mismos reproducen lo que Fisher (2018: 49) denominó la “impotencia reflexiva”, característica de nuestra época. Su estructura narrativa invitaría a los jóvenes espectadores a una lectura aleccionadora sobre los límites de la realidad, llamando a la resignación ante la misma.
Ética demostrada según el orden cosmético
Authors: Ledesma de la Fuente Álvaro
Published: June 2023

Reseña de: Álvarez Solís, Á. (2021): Filosofía de la apariencia física, Madrid: Taugenit, 326 pp.
The Big Scrapbook: La mirada relacional de Alison Smithson
Authors: Casino David
Published: June 2023

El artículo explora la capacidad creativa de Alison Smithson para conjugar sus intereses proyectuales mediante trabajos bidimensionales en papel capaces de dotar a su obra de una poderosa condición experimental, visual y artística. A través de la exploración de un documento sorprendente –y desconocido hasta el momento– denominado The Big Scrapbook, percibimos la mirada asociativa y relacional que esta arquitecta desplegó hacia todo aquello que le rodeaba, construyendo un imaginario personal de fragmentos con el que construir nuevos argumentos y narrativas. En el interior de este atlas personal de ideas y pensamientos, la yuxtaposición aparentemente azarosa de recortes de imágenes de tiempos y significados dispares, impulsa la generación de nuevas conexiones y procesos creativos. En estas nuevas relaciones entre los fragmentos de imágenes se puede apreciar el origen de ciertos intereses clave que dan soporte intelectual a los proyectos de los Smithson.
Observar lo invisible. Radiotelescopios: Infraestructuras entre el paisaje y el cosmos
Authors: García Fernández Carlos , De Abajo Castrillo Begoña , Gutiérrez Llamas Rubén
Published: June 2023

Este artículo investiga acerca de la evolución de un tipo de observatorio astronómico –el radiotelescopio- que desde sus orígenes hasta la actualidad ha ido variando en base a los avances en la ciencia y la tecnología asociadas al campo de la radioastronomía. Se plantea la hipótesis de que el origen de esta rama de la ciencia supuso un cambio de paradigma que conlleva una transgresión de la tipología de los espacios dedicados al conocimiento y la observación del cosmos. Esta nueva clase de observatorio, al mismo tiempo ofrece un nuevo tipo de infraestructuras que, por su gran escala, establece una nueva relación con el paisaje, generando espacios de convergencia entre la naturaleza, la tecnología y la cultura.Se realiza un estudio de seis de los radiotelescopios de gran escala más representativos de su clase, comparando tanto los datos técnicos como los aspectos formales con el objetivo de obtener una serie de conclusiones que contribuyan a un mejor entendimiento de los tipos de espacio que estos producen en relación al paisaje y a los seres humanos.
La cruz y la cortina. Mies o la moderna iconoclastia
Authors: Espuelas Fernando
Published: June 2023

La propaganda al servicio del poder, ya sea político o religioso, ha hecho un abrumador uso de la imagen. Sin embargo, cada cierto tiempo, por agotamiento o por hastío, se producen reacciones contrarias que llevan a la prohibición del uso simbólico de la imagen del cuerpo humano. La posición ideológica que rechaza el uso simbólico de las imágenes humanas ha sido recurrente a lo largo de la historia. Al comienzo del siglo XX el imaginario de las vanguardias reincide en esta inclinación a prescindir de la imagen humana y a sustituirla por artefactos o por la pura abstracción.Acorde con un idealismo no lejano de lo platónico, la abstracción del Movimiento Moderno se intensifica en el vacío que late en la arquitectura de Mies van der Rohe. Esta posición lleva a considerar la presencia humana perturbadora de ese orden perfecto, y, en consecuencia, a prescindir de ella, en lo que puede entenderse como una forma de iconoclasia moderna. La cruz y la cortina son metonimias de los mecanismos que sirven para sustituir o eliminar la imagen y la propia presencia humana.
Fervor moderno en Buenos Aires. La mirada trasatlántica del Grupo Austral y Horacio Coppola en 1939
Authors: Tabera Roldán Andrés , García-Diego Villarías Héctor
Published: June 2023

Buenos Aires era a finales de 1930 una urbe prometedora. El Obelisco, construido en 1936, supuso el icono de una ciudad funcional que comenzaba a abrirse a un ideal de renovación urbana. Pese a ello, la arquitectura argentina se encontraba en un momento confuso, asimilando las formas occidentales con más o menos acierto, pero siempre adoptadas como extrañas. Se pretende profundizar en cómo las páginas del Manifiesto del Grupo Austral respondieron a esta crisis del colectivo de arquitectos y estudiantes argentinos al proponer, especialmente desde su contenido gráfico, una reformulación de la Arquitectura y el Urbanismo para Buenos Aires. Una construcción ideológica gestada en París e importada para Argentina, resultado de la herencia europea vivida por sus principales autores -Antonio Bonet Castellana, Jorge Ferrari-Hardoy y Juan Kurchan- en base a las premisas urbanas de los CIAM, el pensamiento de Le Corbusier y ciertas libertades próximas al surrealismo. Esta construcción trasatlántica elaborada por y para Buenos Aires, pero pensada en clave occidental, contó con un único colaborador externo al grupo, el fotógrafo porteño y "autodidacta" Horacio Coppola. De esta manera y centrándose en esta colaboración entre arquitectos y fotógrafo, el artículo propone cuestionar la propia novedad del Manifiesto Austral para Buenos Aires; ya que las tres fotografías de Coppola contribuyeron, en parte, a reafirmar el carácter vanguardista consustancial al género. Si bien estas mismas fotografías ya habían sido publicadas con anterioridad por Coppola en el célebre libro “Buenos Aires 1936. Visión fotográfica”. La deconstrucción, la identificación y el análisis del material gráfico de las páginas cuatro y cinco bajo el título “Buenos Aires” pretende profundizar en cómo el Manifiesto aportó una nueva mirada sobre la capital porteña. Una mirada que siempre tuvo la alargada sombra de Le Corbusier a sus espaldas y que situaría esta publicación dentro de la categoría de Fotomanifiestos.
El “fotoscop” de Joaquim Gomis y Joan Prats. Secuencia, orden y cadencia
Authors: González Gracia Daniel , Acilu Fernández Aitor
Published: June 2023

Tras años de amistad y colaboración en los círculos culturales defensores del arte nuevo en la Barcelona de la década de 1930, Joaquim Gomis y Joan Prats se reencontraron tras la guerra para concebir un singular artefacto fotográfico que darían en denominar “fotoscop”. Durante las siguientes dos décadas, ambos retratarán mediante su particular lenguaje visual y a través de sus más diversos formatos motivos tan dispares como las anónimas construcciones rurales de la isla de Ibiza o las quiméricas arquitecturas de Antoni Gaudí, arrojando una insólita mirada sobre ambos escenarios. Pero ¿en qué consistía exactamente aquel dispositivo fotográfico? ¿Cuáles eran sus características visuales y propiedades conceptuales? ¿Cómo fue el proceso de gestación de su lenguaje fotográfico? Y, ¿qué impacto tuvo dicho artefacto en el ámbito de la crítica arquitectónica durante las décadas de 1950 y 1960 en lo concerniente al enjuiciamiento crítico de las arquitecturas gaudinianas e ibicencas? Este artículo ahondará en tales cuestiones apoyándose en la revisión crítica de los testimonios y materiales legados por sus protagonistas, algunos de ellos inéditos, para establecer nuevos vínculos y comparaciones con las aportaciones previas de otros autores, a fin de poner en valor dicho legado.
THOMAS F. REESE - Las Nuevas Poblaciones de Sierra Morena y Andalucía. Reforma agraria, repoblación y urbanismo en la España rural del siglo XVIII
Authors: Sambricio Carlos
Published: June 2023

Thomas F. ReeseLas Nuevas Poblaciones de Sierra Morena y Andalucía. Reforma agraria, repoblación y urbanismo en la España rural del siglo XVIIIMadrid: Iberoamericana-Vervuert, 2022. 1.018 pp. Traducción de Jaume Muñoz. Tapa blanda. Idioma: español. 72 €ISBN: 978-84-9192-048-9
GUIDO CIMADOMO (coord.) - Arquitectura española y tecnología. Siete episodios clave del siglo XX
Authors: Jerez Abajo Enrique
Published: June 2023

Guido Cimadomo (coord.)Arquitectura española y tecnología. Siete episodios clave del siglo XXMálaga: Recolectores Urbanos, 2021. 189 pp. Tapa blanda. Idioma: español. 20 €ISBN: 978-84-121493-2-6
Problem-based Learning (PBL) with Reading Questioning and Answering (RQA) of Preservice Elementary School Teachers
Authors: Leasa Marleny , Abednego Abednego , Batlolona John Rafafy
Published: June 2023

Preservice elementary school teachers' critical thinking skills were compared during this quasi-experimental study of PBL (Problem-based Learning) and RQA (Reading-Questioning and Answering) science practicum learning. Following the Covid-19 protocol, the science practicum course was completed online in both the PBL and the PBL with RQA. Face-to-face interaction was limited. Blended learning is completed synchronously by Google Meet and asynchronously by Schoology. The science practicum was conducted offline regarding the limited face-to-face material discussed at the Laboratory. The independent variable consists of two learning models, PBL (control group) and PBL with RQA (treatment group), with critical thinking skills as the dependent variable. The program, which emphasized students' critical thinking skills, lasted about eight weeks. The instrument utilized in this study was a 16-item critical thinking skills test includes indicators of interpretation, analysis, explanation, evaluation, and inference. The data were analyzed by one-way ANCOVA, with critical thinking skills pretest scores as covariates. The findings show that the PBL with RQA has more significant potential to increase students' critical thinking skills than the PBL. RQA allows students to learn independently by reading, summarizing, asking, and answering questions.
Cinco paisajes de poesía y visualidad en Chile. Resistencias y contragolpes
Authors: Polanco Salinas Jorge
Published: June 2023

En este ensayo delineamos cinco constelaciones de prácticas poéticas y visuales, partiendo por la dictadura en Chile (1973-1990), pero conectándolas con obras de las décadas anteriores. Sin querer ser exhaustivos, nuestra intención es mostrar cómo la poesía y las prácticas afines han conformado una respuesta creativa de contra- golpe y antítesis, así como formas de vida resistentes a través del arte en diversos momentos y zonas de Chile.
FOREIGN EXPERIENCE IN THE USE OF ELECTRONIC MEANS IN THE ADMINISTRATIVE JURISDICTIONAL PROCESS
Authors: Anisiforova Mar'yam
Published: June 2023

The article examines the experience of legal regulation (provisions of national legislative and other regulatory legal acts) and administrative and judicial practice of the use of electronic means in administrative and procedural activities by some foreign states. It is concluded that, despite significant progress in the digitalization of judicial systems of foreign countries, the use of electronic means in administrative and jurisdictional activities is still recognized as a new phenomenon and generates various issues and problems caused primarily by insufficient legal regulation in this area.