bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Song for Herman by P. McAllister
Authors: Borle Sean
Published: May 2018

McAllister, Paul. A New Song for Herman. Herman’s Monster House Publishing, 2017.There are many books designed to help children who are afraid of monsters.  This is the second book that Paul McAllister has written on the subject. In this one, Herman, a green House Monster turned Barista Monster, works at Sarah’s cafe and is famous for his mochaccinos. However, his work is suffering because he is being kept awake at night by an Attic Monster. It turns out that the Attic Monster is just baking cookies in an old Easy Bake Oven, so Herman offers him a job baking at the restaurant. The text is simple, but includes some repetition of the Attic Monster’s song “humba rumba lumba rumba gurgle gurgle bing!”, which children will enjoy and will want to repeat during a reading. Both the text and the illustrations help children identify with monsters rather than being afraid of them. Emily Brown has made the monsters look like cuddly stuffy toys. Even the Attic Monster who scares Herman turns out to be “the cutest little monster he’d ever seen.” Brown has also included fun details in the illustrations. For example, when Herman is at his most sleep deprived, he makes the coffee with dirt and Brown shows him holding a coffee pot that has a flower growing out of it. This fun book is recommended for public and school library collections.Recommended: 3 stars out of 4Reviewer: Sean C. BorleSean Borle is a University of Alberta undergraduate student who is an advocate for child health and safety.
My Wounded Island by J. Pasquet and M. Arbona
Authors: Pearce Hanne
Published: May 2018

Pasquet, Jacques and Marion Arbona. My Wounded Island. Translated by Sophie B. Watson. Orca Books, 2017.Imarvaluk lives on a small island called Sarichef on the Chukchi Sea coast of Alaska. Imarvaluk tells the story of how her people live on their island, in their town of Shishmaref. She explains how they used to live in igloos but now live in small wooden homes. The men in her family still hunt bearded seal, walrus, elk, and caribou as their ancestors did. In the summers the family moves to a camp on the mainland by the Serpentine River where they hunt caribou, catch fish, and pick berries.Imarvaluk also tells of how their lives are changing because of the sea, and the monster within it. During winters long ago, the sea would freeze and protect the island from the waves. The ice would also enable her family to hunt. The creature in the sea has caused winter to retreat earlier and earlier, making the pack ice unstable to hunt on, and it slowly swallows the island into the sea. Imarvaluk describes how the home of her people will eventually disappear and how they may have to relocate to Nome, when her island becomes uninhabitable. Through her relationship with her grandfather, Imarvaluk explains how the culture of her people is very much at risk as they face the end of their island.This beautiful and emotionally packed story is remarkable in its ability to convey how environmental impacts are being felt by this Inupiat community. Illustrations by Marion Arbona use paint and texture to convey impactful images of life on Shishmaref, weaving the monster of the changing environment together with Inupiat mythology. It was refreshing to read a children’s book that takes up the very real changes caused by climate change, and in so doing, does not hesitate to leave the ending unresolved. This being said, My Wounded Island could evoke strong emotions and may be better read with an adult, so that there can be discussion about the issues it presents. This doesn’t mean parents should shy away from this book as it is truly a beautiful and impactful read for both young and old.Highly recommended: 4 out of 4 stars Reviewer: Hanne PearceHanne Pearce has worked at the University of Alberta Libraries since 2004. She holds a BA and MLIS and is currently working towards her Master of Arts in Communications and Technology. Her research interests include: visual communication, digital literacy, information literacy and the intersections between communication work and information work. She is also a freelance photographer and graphic designer.
ZAP! Nikola Tesla Takes Charge by M. Kulling
Authors: Distad Merrill
Published: May 2018

Kulling, Monica. ZAP! Nikola Tesla Takes Charge. Illustrated by Bill Slavin. Tundra Books, 2016.In this, her ninth contribution to Tundra Books’ Great Ideas Series, prolific children’s author Monica Kulling distills and simplifies the life and inventions of immigrant engineer and scientist Nikola Tesla (1856–1943) for primary school readers. Confining her story to the first half of Tesla’s long life, from his humble origins in Slovenia (then a part of the Austro-Hungarian Empire), to his achievements as nineteenth-century America’s foremost electrical engineering genius, Kulling has maintained a manageable length compatible with the attention span of her audience.The rivalry between Tesla and his one-time patron and employer, Thomas Edison, over the suitability of alternating versus direct electrical current (AC vs. DC) is described without exposing all the sordid details of their rivalry. The story then quickly moves on to Tesla’s partnership with George Westinghouse to illuminate the 1892-93 Chicago world’s fair site, and to build the first hydroelectric power plant at Niagara Falls, employing alternating current, a system that allowed electricity to be transmitting over greater distances more cheaply and efficiently than Edison’s rival system. Kulling ends her story in 1898, when Tesla demonstrated a model boat controlled by radio waves, an invisible force that he suggested might also be used for wireless communication, a concept soon made real by radio pioneer Guglielmo Marconi.Apart from an anachronistic use of the word “robot,” Kulling’s text is historically and scientifically accurate, clearly written, and age-appropriate, without being condescending. Bill Slavin’s illustrations are nicely evocative of the late nineteenth-century buildings and workshops, and are scaled large enough for story-hour readings to groups of children.Reviewer: Merrill DistadHighly recommended: 4 out of 4 starsMerrill Distad is Associate University Librarian (Research and Special Collections Services) and University Archivist, University of Alberta, and is the co-editor of Peel’s Bibliography of the Canadian Prairies to 1953 (Toronto, 2003). He is the author, most recently, of The University of Alberta Library: The First Hundred Years, 1908–2008 (Edmonton, 2009).
Turtles All the Way Down by J. Green
Authors: Ratcliffe Caitlin
Published: May 2018

Green, John. Turtles All the Way Down. Dutton Books, 2017.  Turtles All the Way Down ticks many boxes; it has friendship, mystery, and romance. Above all, it is the coming-of-age story of a girl struggling with mental illness.Sixteen-year-old Ava Holmes lives within the ever-tightening spiral of her own thoughts. When billionaire Russell Pickett goes missing under suspicious circumstances, Ava and her “Best and Most Fearless Friend,” Daisy, investigate in the hope of pocketing the reward money. Along the way, Ava renews her childhood friendship with Russell’s son, Davis, and their relationship turns romantic as the two teens explore love and their burgeoning sexuality. Yet these elements of typical YA are filtered through the lens of Ava’s mental illness and her daily struggle with profound anxiety, obsessive thinking, and intrusive thoughts. Ava uses the metaphor of an ever-tightening spiral to conceptualize her obsessive thought patterns. The mystery and the romance plotlines are continuously sidelined by Ava’s ongoing struggle with her own mind. Ava’s illness threatens her relationship with Davis, her friendship with Daisy, and, eventually, her life.John Green is a YouTube personality and an award-winning author, best known for The Fault in Our Stars (2012). This novel fits the pattern of Green’s previous works, which feature poignantly relatable teenagers seeking to understand their place in the world. But in Turtles All the Way Down, Green uses the structure of the YA novel to depict the mental illness that has affected his life since childhood. Readers familiar with Green’s virtual presence will hear echoes of his voice in Ava’s. The novel carries the weight of authenticity, as neither Ava nor the reader can find relief from the obsessive thought spirals. By bringing the reader into Ava’s head, Green bridges the gap between language and Ava’s (and his own) abstract experiences. Ava’s chronic mental illness is not magic-ed away, and the novel’s ending is plausible and moving in its truthfulness.     A few elements in the novel feel forced. The climax, for instance, seems to happen simply because the structure of the novel requires one. However, Ava’s daily struggle living with her obsessive thoughts is painfully authentic. Though Green writes through the eyes of a teenage girl, his stream-of-consciousness prose may be easily understood by a wide variety of readers. This novel is a stark, honest, and accessible portrayal of living with mental illness. It is a difficult, astonishing read that is highly recommended for those seeking to understand mental illnesses on a personal level.Highly recommended: 4 out of 4 starsReviewer: Caitlin RatcliffeCaitlin Ratcliffe is an MLIS candidate at the University of Alberta. She completed her Bachelor of Arts with a double major in English and History at the University of Lethbridge. When not studying, she enjoys playing soccer and reading sci-fi, fantasy, and young adult fiction.
In Vitro Gynogenesis and Flow Cytometry Analysis of the Regenerated Haploids of Black Cumin (Nigella sativa)
Authors: El-Mahrouk Mohammed Elsayed , Maamoun Mossad K. , EL-Banna Antar Nasr , Omran Soliman A. , Dewir Yaser Hassan , El-Hendawy Salah
Published: May 2018

In vitro ovule culture could be used to generate homozygous lines through the production of haploid plants. The present study reports on in vitro regeneration and production of haploid plants through ovule cultures and identification of the regenerated haploids using flow cytometry. The ovules were cultured on Murashige and Skoog (MS) medium supplemented with different concentrations of 6-benzyladenine (BA), kinetin (Kin), 2,4-dichlorophenoxyacetic acid (2,4-D), and naphthalene acetic acid (NAA) at 0, 0.5, 1, and 2 mg·L−1 for their gynogenesis. Among different plant growth regulators (PGRs) tested, 2,4-D at 2 mg·L−1 produced direct gynogenesis. The highest callogenesis percentage (100%) was obtained on MS medium containing 1 mg·L−1 2,4-D and 2 mg·L−1 NAA. Flow cytometry analysis was used to identify the regenerated haploids. It also confirmed gynogenic occurrence at 1 and 2 mg·L−1 2,4-D with percentages of 21.7% and 41%, respectively. Therefore, 2,4-D proved effective for the induction of haploids in black cumin. The regenerated haploids were developed on MS medium without PGRs. The obtained results of in vitro gynogenesis and haploid plant production can tremendously facilitate breeding programs of black cumin.
MÉTODO NUMÉRICO PARA SOLUÇÃO DE EDOs RÍGIDAS NA MODELAGEM DE REAÇÕES QUÍMICAS
Authors: Sehnem Rafaela , Sperotto de Quadros Régis , Buske Daniela
Published: May 2018

Problemas envolvendo reações químicas possuem uma característica importante denominada rigidez, indicando que as soluções dos sistemas de EDOs envolvidos variam em diferentes ordens de grandeza. Isso faz com que se escolham métodos numéricos adequados que tenham o intuito de obter soluções numéricas que sejam estáveis e convergentes a um custo computacional reduzido. Os métodos mais eficientes para tratar esse tipo de problema são os métodos implícitos, pois possuem uma região de estabilidade ilimitada no plano complexo que permite grandes variações no tamanho do passo. Neste trabalho propomos um método L-estável: o método de Rosenbrock de quarta ordem com quatro estágios. Simulam-se três problemas envolvendo reações químicas e os resultados apresentam boa concordância com a literatura.
Análisis de las cadenas de suministro de bio-etanol y biodiesel en México: Estudio de caso
Authors: Rosas Barajas José Alfredo , Aguilar Ortega Andrés , Cornejo Corona Ivete , Rizo Fernández Zenon , Córdova de la Cruz Saúl Edén , Ramos Frausto Luis Gerardo , Esparza Claudio José de Jesús
Published: May 2018

El trabajo identificó y analizó el estado actual de los principales actores que intervienen en las cadenas de suministro de biocombustibles líquidos en el sureste de México. Se incluye la descripción del proceso de producción de: biodiesel, bioetanol y aceite de ricino. El  caso A se refiere a  una empresa que a partir de aceites vegetales reciclados produce biodiésel, el caso B se refiere a una empresa que utiliza melazas para producir etanol anhidro mediante un tamiz molecular, el caso C  describe la gestión de la cadena de suministro, desde la orga-nización de los agricultores hasta el proceso de producción de aceite de ricino y su comer-cialización para la industria, los centros INIFAP están trabajando en la mejora de la semilla de  jatropha para su uso colectivo en las zonas potenciales de cultivo.
Evaluación de una vacuna de ADN y su péptido recombinante contra inhibina alfa (165-300) sobre la respuesta inmune y fertilidad en ratones
Authors: Luna-Palomera Carlos , González-González Juan , Gayosso-Vázquez Amanda , Ramírez-Andoney Vianey , Ojeda-Robertos Nadia Florencia , Aguilar-Cabrales Julio Armando , Alonso-Morales Rogelio Alejandro
Published: May 2018

Se evalúo la vacuna de ADN (INHA-DNA) y su péptido recombinante (INHA-rec) contra inhibina alfa (INHA) sobre la respuesta inmune y la fertilidad en ratones. Dieciséis ratones Balb/c fueron divididos en dos grupos, 8 cada uno. Bajo un esquema de inmunización prime boost heterólogo, un grupo fue inoculado vía intramuscular (IM) con 100 µg de INHA-DNA y 14 d después con 100 µg de INHA-rec. El grupo control recibió solución salina. Se aparearon las hembras en dos ocasiones. Posterior al primer parto se dio un refuerzo vía IM con ambos inmunógenos (100 µg INHA-DNA + 100 µg INHA-rec). La inmunización con 100 µg de INHA-DNA y INHA-rec indujo altos niveles de anticuerpo anti INHA, mayor tamaño y peso de camada (P<0.05) comparados con el control. La fertilidad promedio fue similar entre los tratados (67%) y control (60%). En conclusión, la vacuna de ADN y su antígeno recombinante es capaz de inducir títulos de anticuerpos contra INHA incrementando el tamaño de camada, sin un efecto negativo sobre la fertilidad en ratones.
Antioxidant and Antitumor Metabolites of Saudi Red Sea Seagrasses Halodule uninervis and Thalassia hemprichii
Authors: Ghandourah Mohamed , Hawas Usama W. , Abou El-Kassem Lamia T. , Bamkhrama Munir , Taie Hanan A.A.
Published: May 2018

The present study aimed to investigate the chemical constituents, and antioxidants and antitumor
activities of the seagrasses Halodule uninervis and Thalassia hemprichii. Seventeen compounds
were isolated from both seagrasses, and identified as flavonoids, phenolic acids, nitrogen compound,
steroids and fatty acids. Their structures were established by spectral analysis (UV, MS, and 1D- and
2D-NMR) and chemical investigation (for glycosides). The total metabolites of each seagrass and the
isolated flavonoids tested in different in vitro assays (DPPH, ABTS, FRAP, Fe2+ chelating, reducing
power, and Ehrlich ascites carcinoma cell line) showed significant antioxidant and antitumor activities.
H. uninervis extract revealed good antioxidant activities compared to water and butanol extracts of T.
hemprichii, while quercetin 3-O-β-glucoside from H. uninervis revealed potent antioxidant activity at
concentration of 25µg/ml. Moreover, the seagrasses extracts were displayed mild antitumor activity
against Ehrlich ascites carcinoma cells in mice with less undesirable side effects compared to vincristine
as a drug control.
Transition Metal-Catalyzed Reactions of 3-Aza-2-oxabicyclo[2.2.1]hept-5-enes
Authors: Tait Katrina , Tam William
Published: May 2018

Background: Transition metal catalysts are becoming increasingly more important in organic synthesis
and are being used to catalyze novel reactions that allow for more efficient synthesis of many pharmaceuticals.
Transition metal-catalyzed reactions of 3-aza-2-oxabicyco[2.2.1]hept-5-enes provide efficient synthetic
pathways to generate a diverse range of biologically and synthetically useful products. 3-Aza-2-
oxabicyclic alkenes undergo three main types of reactions: reductive N-O bond cleavage, C-O bond cleavage,
and modification of the alkene component.

Objective: The purpose of this review is to summarize and discuss the transition metal-mediated reactions of 3-
aza-2-oxabicyclo[2.2.1]hept-5-enes, including the mechanisms of reactions based on the transition metal used,
the different stereo- and regiochemical outcomes of reactions with this asymmetrical substrate, and the biological
importance of exploring these reactions.

Conclusion: It is clear from the review of the topic that a vast amount of work has been done in this area, and
transition metals have been used to control the regio- and stereoselective reactions of 3-aza-2-oxabicyclic alkenes
to create biologically active and synthetically useful products. The transition metal-catalyzed reactions of
3-aza-2-oxabicyclic alkenes proceed through three general reactions: through cleavage of the N-O bond, cleavage
of the C-O bond, and modification of the alkene component. Without the use of transition metals, the substrate
would not be activated and these reactions would not be possible. The use of transition metals opens up
an array of new reactions that have the ability to create different functional groups with different regio- and
stereoselectivities based on the metal and conditions used. The products made through these transition metalcatalyzed
reactions can be useful as antibiotics, siderophores, and carbocyclic nucleosides such as noraristeromycin
and carbocyclic polyoxin C.
Oximes of Nucleosides and Related Compounds: Synthesis, Reactions and Biological Activity
Authors: Abele Edgars , Abele Ramona
Published: May 2018

Background:

Literature data on the synthesis and structure of oximes of nucleosides and related nitrogenous
bases from pyrimidine and purine were reviewed. Synthesis of novel heterocyclic systems from nucleoside
oximes related pyrimidine oximes was described. The biological activity of derivatives of nucleoside
and nitrogenous base oximes was also reviewed.

Objective: The review focuses on the recent progress in the area of nucleoside oxime synthesis, reactions and
biological activity.

Conclusion:

In summary, literature data on the synthesis and structure of oximes of nucleosides and related
nitrogenous bases derived from pyrimidine, which play an important role in the biological processes, were reviewed.
Synthesis of novel heterocyclic systems from nucleoside oximes related pyrimidine oximes was described.
The biological activity of derivatives of nucleoside and nucleotide oximes was also reviewed. The
studied class of compounds show a wide range of imino-amino and imino-nitroso tautomerism, which was investigated
in the presented literature by 1H, 13C and 15N NMR spectroscopy methods. Also, according to the
authors point of view, due to imino-amino and/or imino-nitroso tautomerism the nucleoside oximes show interesting
activity. Most of the compounds exhibit biological activity characteristic of not only oxime derivatives,
but also activity of hydroxylamines or nitroso compounds.
Effect of Carrot Pomace Powder and Dushab (Traditional Grape Juice Concentrate) on the Physical and Sensory Properties of Cakes: A Combined Mixtures Design Approach
Authors: Mohtarami Forogh
Published: May 2018

Background:

Carrot pomace powder (CPP), a valuable by-product of carrot processing, and Dushab, a traditional grape juice concentrate, can be utilized for enrichment of products.

Methods:

Combined mixtures methodology using D-optimal design was found to be an effective technique to investigate the effects of replacing wheat flour and sucrose with CPP and Dushab on water activity, moisture content, specific volume, crumb color and textural properties of cakes and their sensory evaluation.

Results:

Moisture content, color difference and browning index of cakes increased with an increase in the amount of CPP and Dushab substitution. The specific volume of the cakes reduced in the supplemented CPP and Dushab cakes. By increasing the level of CPP and Dushab, the firmness of the cakes increased whereas cohesiveness decreased. Chewiness and gumminess were not affected by Dushab substitution but increased by the increment of CPP. Dushab substitution led to the decline of cake springiness compared to the control one. The least sensory accepted product, with a mean score of 0.7 in a scale from 0 to 1, had the maximum substitution of CPP (24% wheat flour) and Dushab (100% sucrose).

Conclusion:

The optimization tool indicated that a functional cake with high desirability can be achieved with the substitution of 10% wheat flour by CPP and 65% sucrose by Dushab.
4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors
Authors: Borkar Maheshkumar R. , Nandan Santosh , Nagaraj Harish K.M. , Puttur Jayashree , Manniyodath Jisha , Chatterji Dipankar , Coutinho Evans C.
Published: May 2018

Background:

The treatment of a bacterial infection when the bacterium is growing in a
biofilm is a vexed issue. This is because the bacteria in a biofilm behaves differently compared to
the individual planktonic free-form. As a result, traditional antibacterial agents lose their activity.

Objective:

Presently, there are not many drugs that are effective against bacteria growing in
biofilms. Based on literature reports, we have sought to develop novel derivatives of 4-hydroxy-2-
pyridone as both antimycobacterial and antibiofilm agents.

Methods: The pyridone derivatives were synthesized by reacting 4-hydroxy-6-methyl-2H-pyran-2-
one with appropriate amines and followed by reaction with substituted phenyl isocyanates as reported
in the literature.

Results:

Four compounds in this series significantly inhibit the growth and formation of biofilm by
Mycobacterium smegmatis (mc2 155 strain) at 50 µg/ml. Further, in silico evaluation of the ADME
parameters shows that these compounds possess good drug-like properties and have the potential
to be developed both as antibiofilm and as oral antimycobacterial agents.

Conclusion:

This finding is of significance as presently very few small molecules are known to
inhibit biofilm formation in mycobacteria. These compounds are unique in the sense that they are
more potent against Mycobacterium smegmatis in the biofilm state compared to the planktonic
form.
Neuropharmacological Screening of Chiral and Non-chiral Phthalimide- Containing Compounds in Mice: in vivo and in silico Experiments
Authors: Campos-Rodríguez Carolina , Trujillo-Ferrara José G. , Alvarez-Guerra Ameyali , Vargas Irán M. Cumbres , Cuevas-Hernández Roberto I. , Andrade-Jorge Erik , Zamudio Sergio , Juan Eduardo R.-S.
Published: May 2018

Background:

Thalidomide, the first synthesized phthalimide, has demonstrated sedative-
hypnotic and antiepileptic effects on the central nervous system. N-substituted phthalimides
have an interesting chemical structure that confers important biological properties.

Objective:

Non-chiral (ortho and para bis-isoindoline-1,3-dione, phthaloylglycine) and chiral
phthalimides (N-substituted with aspartate or glutamate) were synthesized and the sedative, anxiolytic
and anticonvulsant effects were tested.

Method:

Homology modeling and molecular docking were employed to predict recognition of the
analogues by hNMDA and mGlu receptors. The neuropharmacological activity was tested with the
open field test and elevated plus maze (EPM). The compounds were tested in mouse models of
acute convulsions induced either by pentylenetetrazol (PTZ; 90 mg/kg) or 4-aminopyridine (4-AP;
10 mg/kg).

Results:

The ortho and para non-chiral compounds at 562.3 and 316 mg/kg, respectively, decreased
locomotor activity. Contrarily, the chiral compounds produced excitatory effects. Increased
locomotor activity was found with S-TGLU and R-TGLU at 100, 316 and 562.3 mg/kg,
and S-TASP at 316 and 562.3 mg/kg. These molecules showed no activity in the EPM test or PTZ
model. In the 4-AP model, however, S-TGLU (237.1, 316 and 421.7 mg/kg) as well as S-TASP
and R-TASP (316 mg/kg) lowered the convulsive and death rate.

Conclusion:

The chiral compounds exhibited a non-competitive NMDAR antagonist profile and
the non-chiral molecules possessed selective sedative properties. The NMDAR exhibited stereoselectivity
for S-TGLU while it is not a preference for the aspartic derivatives. The results appear to
be supported by the in silico studies, which evidenced a high affinity of phthalimides for the
hNMDAR and mGluR type 1.
Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis
Authors: Gul Halise Inci , Tugrak Mehtap , Gul Mustafa , Sakagami Hiroshi , Umemura Naoki , Anil Baris
Published: May 2018

Background:

In this study, new azafluorenones, 4-(4-fluorophenyl)-2-(4-substitutedphenyl)-5Hindeno[
1,2-b] pyridin-5-one, I1-I8 were synthesized and chemical structures were elucidated by spectral analysis.
All compounds were reported for the first time here.

Method:

Compounds were tested in terms of cytotoxicity. They were found as cytotoxins/anticancer
compounds.

Results:

It was found that the lead compounds of the series were I5 and I8 according to SI, TS, PSE calculations.
When PSE values were considered, compound I5 having chlorine had the highest PSE value of 126.4.
Second highest PSE value of 50.5 belonged to I8, which had thiophene ring in its chemical structure. I8 as a
representative compound of the series was forwarded to cell cycle analysis. I8 arrested S phase of the cell cycle
and lead to apoptosis by inducing PARP cleavage suggesting that at least one of the mechanisms of cytotoxic
action of the series was apoptosis.

Conclusion:

It was clearly demonstrated that compound I8 can induce early apoptosis at a concentration of 5
µM. The compounds I5 and I8 can be considered as lead compounds of the series with the highest SI, TS, PSE
values for further studies.
Clinical Pharmacology of Oral Anticoagulants in Patients with Kidney Disease
Authors: Jain Nishank , Reilly Robert F.
Published: May 2018

Oral anticoagulants are commonly used drugs in patients with CKD and patients with ESKD to treat atrial fibrillation to reduce stroke and systemic embolism. Some of these drugs are used to treat or prevent deep venous thrombosis and pulmonary embolism in patients with CKD who undergo knee and hip replacement surgeries. Warfarin is the only anticoagulant that is approved for use by the Food and Drug Administration in individuals with mechanical heart valves. Each oral anticoagulant affects the coagulation profile in the laboratory uniquely. Warfarin and apixaban are the only anticoagulants that are Food and Drug Administration approved for use in patients with CKD and patients with ESKD. However, other oral anticoagulants are commonly used off label in this patient population. Given the acquired risk of bleeding from uremia, these drugs are known to cause increased bleeding events, hospitalization, and overall morbidity. Each anticoagulant has unique pharmacologic properties of which nephrologists need to be aware to optimally manage patients. In addition, nephrologists are increasingly asked to aid in the management of adverse bleeding events related to oral anticoagulant use in patients with CKD and patients with ESKD. This article summarizes the clinical pharmacology of these drugs and identifies knowledge gaps in the literature related to their use.
Getting Better Intestinal Health through the Addition of Yeast (Saccharomyces Cerevisiae) Combined with Threonine in Broilers Diets
Authors: Peralta María F. , Nilson Armando J. , Miazzo Raúl D.
Published: May 2018

The aim was to evaluate the association of Saccharomyces cerevisiae (Sc) with Threonine (T) in broiler diets, on performance, carcass quality and gut histomorphometric variables. One hundred Ross male broilers (1 to 43 days old) were distributed into four treatments. D1: commercial type, plus 5 g Sc/Kg food, D2: D1 plus 15% T, D3: D1 plus 30% T, D4: D1 plus 45% T. Performance productive were measured as Average Daily Weight Gain (ADWG) (g/broiler/day), Average Daily Consumption Feed (ADCF) (g/broiler/day) and Feed Conversion Ratio (FCR). Carcass quality was determined as Breast Weight (BW) (g), Thigh Weight (TW) (g) and Abdominal Fat Weight (AFW) (g). In gut were measured: Villus Height (VH) (µ), Crypt Depth (CD) (µ) and VH/CD Ratio. Results: BW and TW increased and AFW decreased in D3 and D4 groups (p ? 0.05). In gut, all groups received T decreased VH/CD Ratio (p ? 0.05) and increased goblet cells number producing higher mucus. Conclusion: Sc associate with T increased carcass quality of broiler through a healthy gut, that could be generated by more mature epithelia that enhancing absorptive function through the efficient use of nutrient and increasing protective function through mucosal hypersecretion by increased goblet cell number.
Enhancing Cultural Intelligence and Interpersonal Communication: Multi-Authenticity Exposure in English as a Foreign Language (EFL) Context
Authors: Bahrami Anahid , Narafshan Mehry Haddad
Published: May 2018

The current study focuses on authentic exposure, specifically whether multi-authentic tasks affect the nature of L2 learners’ cultural intelligence and interpersonal communication in the English as a foreign language (EFL) context of Iran. To this end, sixty learners at an English language institute were assigned to control and experimental groups to carry out the M-A tasks. M-A was manipulated by assigning visual, aural, and printed tasks. Descriptive and inferential analyses of data, a comparison of the control and experimental groups over a four-month period, revealed that the implementation of authentic materials was successful in raising the cultural intelligence and interpersonal communication of EFL learners in the post-test. A subsequent ANOVA analysis showed that among M-A materials, visual was the most and aural was the least effective one increasing EFL learners’ cultural intelligence. Moreover, the printed material was the most effective one to make a moderate change in interpersonal communication of the participants.
Impacts of Authority and Unanimity on Social Conformity in Online Chats about Climate Change
Authors: Farmer Yanick , Bissière Mehlia , Benkirane Amina
Published: May 2018

Background The purpose of this study was to examine whether two variables of persuasive communication, authority and unanimity, induce social conformity when people communicate over digital social media without knowing each other.

Analysis Data collection was based on a mixed methodology. In all, 26 subjects were tested ( N = 26).

Conclusions and implications The research showed that the tendency of conforming to groups is maintained in online communications. However, the level of such conformity is not as high as the level that prevails in face-to-face communication.
Without a Paddle: Schitt’s Creek, CBC, and the Return to Community and Family in Uncertain Times
Authors: Patrick Stephanie
Published: May 2018

Background The Canadian television landscape is a key site through which national identity is expressed and debated. This article examines one such site—the recent CBC hit comedy Schitt’s Creek(2015–)—that depicts economic uncertainty, family, and community.

Analysis A textual analysis of the show and a cultural analysis of its production highlight the parallels between precarious Canadian identity and precarious economic conditions in the neoliberal era.

Conclusions and implications Schitt’s Creekbuilds on other “retreatist” texts that portray small-community life and family as sites of stability in times of uncertainty. Yet it de-localizes this community from the Canadian context, using stars and the CBC platform, rather than content, to signify place. The author argues that these alternative signifiers of “Canadian-ness” along with a marked shift in tone potentially account for the show’s broad appeal.
An Inquiry into the Political Economy of Hockey Night in Canada: Critically Assessing Issues of Ownership, Advertising, and Gendered Audiences
Authors: Phillips Ryan J.
Published: May 2018

Background This article employs a political economic analysis of the CBC’s Hockey Night in Canada (HNIC) program. It critically investigates both the recent Rogers Communications takeover of the popular public broadcasting program and the history of HNIC’s gendered audiences.

Analysis Utilizing a feminist version of Dallas Smythe’s theory of the audience commodity, the author argues that the Rogers takeover represents the most recent manifestation of the complicity between patriarchy and capitalism that has persisted throughout the history of HNIC.

Conclusion and implications It is also argued that the general political economy of HNIC represents a site of analysis that has been largely ignored by communications scholars, and that the program’s significance as a Canadian institution thus merits further critical inquiry.
Customer experience with farmers’ markets: what hashtags can reveal
Authors: Pilař Ladislav , Balcarová Tereza , Rojík Stanislav , Tichá Ivana , Poláková Jana
Published: May 2018

Social media networks are increasing in popularity and have been integrated into many aspects of daily life. Analysis of the ways in which individuals use social media is important for understanding social, cultural, and environmental issues. This study examines experiences of farmers’ market customers through their self-expression on social networks. Contributions to the Instagram social network based on the #farmersmarket hashtag were gathered on a single day, yielding 19,398 contributions created by 13,862 users. Six major linked hashtags were identified (#Organic, #Fresh, #Food, #Local, #Vegan, and #Healthy), providing key indicators of the characteristics of farmers’ markets that are valued by customers. Four customer segments were identified: Product Oriented, Emotional Oriented, Social Oriented, and Product-Social Oriented, with strong interconnections identified between these communities. The results of this study provide insights into consumer values and behaviors in the farmers’ market context and will be of practical use for future marketing and management.
Pseudo Picard operators on generalized metric spaces
Authors: Altun Ishak , Samet Bessem
Published: May 2018

In this paper, we present a new class of pseudo Picard operators in the
setting of generalized metric spaces introduced recently in [M. Jleli and B.
Samet: A generalized metric space and related fixed point theorems, Fixed
Point Theory Appl., (2015) 2015:61]. An example is provided to illustrate
the main result.
Self-Reflective Insights on What I Have Learned in an Evolving Academic Career Model: Accounting Scholarship, Administration, and Diversity
Authors: Callahan Carolyn M.
Published: May 2018

In this paper, I offer personal insights based on my experiences (thus far) in an evolving academic accounting career model. While I value all aspects of an academic career responsibilities (teaching, research, and service), this narrative focuses primarily on the role of accounting scholarship and, broadly, the impact of diversity on the same. I offer these perspectives and personal experiences from the unique vantage point as an African American woman, focused first on contributing to top-tired accounting scholarship, and more recently on roles as an administrator of an accounting department and business college. While my academic journey is unique by objective measures (often dubbed “trailblazing” by others), I offer suggestions that may be useful to any academic who is dedicated to success in our field. Given the evolving accounting model and challenges ahead, my overriding goal remains to encourage junior accounting colleagues to persevere, as an accounting academic career is richly rewarding.
Using Visualization Software in the Audit of Revenue Transactions to Identify Anomalies
Authors: Cunningham Lauren M. , Stein Sarah E.
Published: May 2018

Recent changes in the accounting profession require students to enter the workforce with technical and critical-thinking skills using large datasets. In an audit setting, an important skill is the ability to identify anomalies and risk factors in the client's data. This instructional case provides students with experience using visualization to identify anomalous transactions for further substantive testing based on relationships between financial data (revenues) and nonfinancial data (weather patterns). Students must also create a memo for the workpaper files that documents their findings, including recommendations for the audit team to select specific sales transactions for substantive testing. Aside from gaining experience with Tableau visualization software, this case will improve students' problem-solving and analytical skills by encouraging them to work independently and to break a complex problem into manageable pieces. This case is most applicable for implementation in undergraduate or graduate auditing or internal auditing courses.
Intersex in the Age of Queer Bioethics
Authors: Tunstall Emma , Moore Sarah Kay , Wahlert Lance
Published: May 2018

Queer Bioethics and the inventory of its potential populations include a wide range of queer subjects: lesbian parents, HIV-positive gay and bisexuals, transgender youth, and non-cisgendered individuals, to name a few. With the ethical dilemmas and ethical duties couched inside of a Queer Bioethics in mind, this article will consider one of the field’s most enduring citizens: the intersex child. More specifically, the figure of the intersex child with ovotesticular non-normativity will be scrutinized on ethical and clinical planes – a major aspect of queer bioethics is, after all, clinical ethics for queer populations. Ovotesticular conditions will be covered at length; we discuss different variations in addition to narrowing the topic to those with 46,XX and ambiguous genitalia, specifically those 75% diagnosed under the age of 20, and speak on issues related to this population. We will also briefly discuss the population of the 20% diagnosed under the age of 5 years old. Interventions will be discussed in all realms of intersex conditions – specifically ovotestes. We will conclude with a principalist approach to ethical topics such as autonomy, beneficence, and non-maleficence, weighing these principles equally and ultimately erring on the side of autonomy within pediatric ethics where possible.
"Surkean surkea uutinen"
Authors: Kejonen Eetu
Published: May 2018

Artikkelissa analysoidaan miesparin lähetystyöhön siunaamisesta virinnyttä keskustelua Seurakuntalainen-nettilehdessä hyödyntäen Sari Charpentierin 1990-luvun parisuhdekeskustelun yhteydessä esille nostamaa pyhän järjestyksen käsitettä. Artikkeli liikkuu kahden keskustelun ja tutkimusperinteen – kirkollis-teologisen ja sukupuolentutkimuksen – välisillä rajapinnoilla. Analyysissä nousee erityisesti esille se, miten voimakkain sanakääntein tapahtunutta kommentoitiin. Materiaali todistaa Suomen evankelis-luterilaisen kirkon niin kutsuttujen konservatiivien ja liberaalien välisistä jakolinjoista. Kommentoinnissa vähemmistöksi jääneissä ”liberaaleissa” kommenteissa tapahtunutta puolustettiin muun muassa lähimmäisenrakkauteen ja syrjimättömyyteen vetoamalla. Palstaa hallinnut ”konservatiivinen” kommentointi keskittyi Raamatun arvovallan puolustamiseen tavalla, joka sisälsi selkeitä heteronormatiivisia ja kristillis-konservatiivisia, mutta samalla myös maallisemmista argumentaation tavoista nousevia käsityksiä. Katson, että kommentointia voidaan lähestyä ja sanoittaa pyhän järjestyksen kaltaisten selitysmallien avulla. Lähettipäätöksen herättämä keskustelu voidaan kytkeä myös muihin näkökulmiin, joiden avulla on nähtävissä sen yhteys nykyiseen kulttuuriseen tilanteeseen ja heteronormin horjumiseen myös Suomen evankelis-luterilaisen kirkon piirissä.
Considering Unicorns
Authors: Sudenkaarne Tiia
Published: May 2018

This article discusses queer bioethics, a critical stance for dismantling cis- and heteronormativity in bioethics, together with intersectionality, the investigation of and potential for social justice-oriented change. I discuss the difficulties of navigating plurality with solidarity and ethical sobriety that I call the problems of identity, essentialism and relativism in intersectionality theory. I then proceed to ponder how queer bioethics relates to intersectionality, and close by offering some remarks for further research.

Certain intersectional approaches share key queer bioethical imperatives in exposing how seemingly neutral antidiscrimination discourses rely on bias and privilege. Both powerfully demonstrate how ostensibly objective methodologies are often inadequate for addressing socially sanctioned bias or for unpacking oppressive habits of the mind. Intersectionality interrupts narrative norms and disrupts easy binaries, such as male/female or homo/hetero. Because it is practice-oriented and has a social justice mission, intersectionality approaches analysis and advocacy as necessarily linked, which corresponds to queer bioethics arising from LGBTQI activism. However, establishing intersectional queer bioethics requires further investigation into cases of race, sexual and gender diversity with queer bioethics as the background moral theory, formulation of which I suggest should be inspired by feminist metaphysical advances.
Regulating Action of in Vitro Hepatitis C Virus Infection on Interferon-Induced Interferon Stimulating Genes in Murine Macrophages
Authors: Sandagdorj Dolgorsuren , Munkhjargal Batkhishig , Enkhjargal Baasansuren , Tuvdenjamts Baljinnyam , Zorigt Enkhjin , Jadamba Budjav , Chinbat Altanshagai , Samdankhuu Khongorzul , Jambalganii Ulziisaikhan , Boldbaatar Batsuren , Sandag Tsogtsaikhan , Tsolmon Bilegtsaikhan , Lkhagvasuren Enkhsaikhan
Published: May 2018

Objectives: The objective of this study was to determine the in vitro regulating effect of Hepatitis C virus (HCV) infection on interferon stimulating genes (ISGs) stimulated by IFN-ү and Imiquimod (TLR7 ligand) on murine macrophages. iNOS and STAT1 were measured by RT-PCR, and immunoblotting (IB). Nitric oxide production was measured by Griess Reagent Assay. Objectives: The objective of this study was to determine the in vitro regulating effect of Hepatitis C virus (HCV) infection on interferon stimulating genes (ISGs) stimulated by IFN-ү and Imiquimod (TLR7 ligand) on murine macrophages. iNOS and STAT1 were measured by RT-PCR, and immunoblotting (IB). Nitric oxide production was measured by Griess Reagent Assay. Results: HCV inhibits IFN induced iNOS mRNA and also protein expression. HCV significantly reduced IFN-ү induced ISGs (iNOS mRNA, iNOS protein, s727-STAT1, tyr701- STAT1). Conclusion: These results indicate that in vitro hepatitis C virus infection is involved in the regulation of IFN-ү induced ISGs in the levels of gene and protein expression of iNOS and STAT1 transcription factors.: HCV inhibits IFN induced iNOS mRNA and also protein expression. HCV significantly reduced IFN-ү induced ISGs (iNOS mRNA, iNOS protein, s727-STAT1, tyr701- STAT1). Conclusion: These results indicate that in vitro hepatitis C virus infection is involved in the regulation of IFN-ү induced ISGs in the levels of gene and protein expression of iNOS and STAT1 transcription factors.
11.Sınıf Öğrencilerinin Türk Dili ve Edebiyatı Dersinde Uygulanan Söylem Çözümleme Yöntemine İlişkin Görüşleri
Authors: ÜNVEREN KAPANADZE Dilek , KAYA Turhan
Published: May 2018

Bu çalışmanın amacı, söylem çözümleme yönteminin Türk
Dili Edebiyatı öğretimine; okuma, anlama, metin çözümleme ve dil kullanımı
becerileri açısından etkisini belirlemek, bu konuda öğrenci görüşlerini elde
etmektir. Araştırmanın çalışma grubunu 2014–2015 Eğitim-Öğretim yılı bahar
döneminde, Erzurum il merkezinde yer alan Özel Bilkent Erzurum Laboratuvar
Lisesi’nde öğrenim görmekte olan 11. sınıf öğrencileri oluşturmaktadır.
Araştırmada nitel araştırma yöntemi kullanılmıştır. Öğrencilerin Türk Dili ve
Edebiyatı derslerinde söylem çözümleme yönteminin kullanılmasına ilişkin görüş
ve düşünceleri yöntem uygulanmadan önce ve uygulandıktan sonra öğrencilere
uygulanan görüş formları yoluyla toplanmıştır. Ayrıca, uygulamayı yapan
araştırmacının gözlemleri ve uygulama sonunda “görüşme” tekniğinden
faydalanılarak video kaydı alınan öğrenci görüşleri de incelemeye dahil
edilmiş, verilerin birbirini desteklediği görülmüştür. Toplanan verilerin
analizinde betimsel analiz ve içerik analizi yaklaşımı kullanılmıştır. Araştırma
sonucunda; söylem çözümleme yönteminin süreci etkin hale getirdiği,
öğrencilerin okuma, anlama, metin çözümleme ve dil kullanımı becerilerinin
gelişimini sağladığı, anlamlı, kalıcı ve başka alanlarla aktarılabilecek
öğrenme durumları oluşturduğu, öğrenciler üzerinde derse güdülenme ve aktif
öğrenme açısından etkili olduğu, eğitim sürecini zevkli hale getirerek derse
katılımı arttırdığı, öğrencilerin sosyal ve iletişim becerilerine de katkı
yaparak kişisel gelişimlerini desteklediği sonuçları ortaya çıkmıştır. Okuma ve
anlama becerisinin bireylerin tüm yaşantısında ve öğrenme alanlarında etkili
olduğu, söylem çözümleme yönteminin bir metin çözümleme tekniği olarak
kullanıldığı çok az çalışmanın olması ve ana dil ve edebiyat derslerinde
öğretim yöntemi olarak kullanıldığı bir çalışmanın bulunmuyor olması gibi
nedenlerle çalışmanın eğitim bilimleri alan yazınına önemli katkılar
sağlayacağı düşünülmektedir
The Grammatical Errors in Debate Arguments Made by Students of Global English Language Center
Authors: Nikmawati Adina , Syahri Indawan , Susanti Rini
Published: May 2018

The thesis entitled Grammatical Errors in Debate Arguments Made by the Students of Global English Language Center. The objectives of this study were (1) to find out the kinds of errors made by the students of Global English Language Center in their debate arguments and (2) to find out the causes of errors made by the students of Global English Language Center in their debate arguments. The writer used descriptive-qualitative method of research. The population of this study was all the students of Global English Language Center. The sample was chosen by using purposive sampling. The samples were 12 students which were grouped into two debate sessions. The data were calculated and analyzed based on surface strategy taxonomy and linguistic category taxonomy to know the errors. Samples’ personal reasons and personal judgement were used to know the causes of the errors. The findings showed that there were four types of errors that the students made which are omission, addition, misformation, and misordering. Misformation is the major error made by the students. Nervousness, time limit, native language interference, and the insufficient grammar learning were the causes why the students made errors.
Translation of Film Titles Based on Intercultural Communication
Authors: Qin Jing
Published: May 2018

To illustrate cultural differences between China and the western world in translating film titles. Film industry plays a vital role in cultural communications, especially in the trend of globalization, which attaches a greater importance to film title translation than ever before.  Some of theories concerning cultural differences will be discussed, including Hall’s high-context and Low-context orientations and Hofstede’s value dimensions. The study finds that with the help of these theories, certain translation methods can be utilized by translators in order to do a better job when translating titles of imported films.