bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Report: Septic Pericarditis With Achromobacter xyloxidans in an Immunosuppressed Dog
Authors: Pascutti Kristina M. , Dolan Jacqueline K. , Porter Lauren T. , Gilor Shir , Harris Autumn N.
Published: May 2022

A 5-year-old female spayed French Bulldog presented for anorexia and increased respiratory rate. On presentation, she was dyspneic with stridor and increased bronchovesicular sounds. Point-of-care ultrasound identified pericardial effusion. Thoracic radiographs identified pleural effusion, a wide cranial mediastinum, and multifocal unstructured interstitial pulmonary opacities. Bloodwork revealed a moderate leukocytosis characterized by a mature neutrophilia with a left shift, hypoalbuminemia, mildly increased alkaline phosphatase activity, and moderate hypokalemia. Thoracic CT findings revealed moderate pericardial and bilateral pleural effusion, mediastinal effusion, and moderate cranial mediastinal lymphadenopathy. Diagnostic thoracocentesis and pericardiocentesis revealed septic exudates with bacilli. Two days later, a median sternotomy and pericardiectomy were performed. Aerobic cultures of the effusions grew Achromobacter xylosoxidans ss deitrificans. The patient was treated with Amoxicillin-clavulanate and enrofloxacin for 12 weeks and clinically fully recovered. Achromobacter xylosoxidans has not been reported as a cause of purulent pericarditis and pyothorax in a dog. Uniquely, this patient is suspected of developing this infection secondary to immunosuppression.
Evaluating Cognitive Enrichment for Zoo-Housed Gorillas Using Facial Recognition
Authors: Brookes Otto , Gray Stuart , Bennett Peter , Burgess Katy V. , Clark Fay E. , Roberts Elisabeth , Burghardt Tilo
Published: May 2022

The use of computer technology within zoos is becoming increasingly popular to help achieve high animal welfare standards. However, despite its various positive applications to wildlife in recent years, there has been little uptake of machine learning in zoo animal care. In this paper, we describe how a facial recognition system, developed using machine learning, was embedded within a cognitive enrichment device (a vertical, modular finger maze) for a troop of seven Western lowland gorillas (Gorilla gorilla gorilla) at Bristol Zoo Gardens, UK. We explored whether machine learning could automatically identify individual gorillas through facial recognition, and automate the collection of device-use data including the order, frequency and duration of use by the troop. Concurrent traditional video recording and behavioral coding by eye was undertaken for comparison. The facial recognition system was very effective at identifying individual gorillas (97% mean average precision) and could automate specific downstream tasks (for example, duration of engagement). However, its development was a heavy investment, requiring specialized hardware and interdisciplinary expertise. Therefore, we suggest a system like this is only appropriate for long-term projects. Additionally, researcher input was still required to visually identify which maze modules were being used by gorillas and how. This highlights the need for additional technology, such as infrared sensors, to fully automate cognitive enrichment evaluation. To end, we describe a future system that combines machine learning and sensor technology which could automate the collection of data in real-time for use by researchers and animal care staff.
Initial Experience With SARS-CoV-2-Neutralizing Monoclonal Antibodies in Kidney or Combined Kidney-Pancreas Transplant Recipients
Authors: Bachmann Friederike , Budde Klemens , Suttorp Norbert , Lingscheid Tilman , Stegemann Miriam Songa , Osmanodja Bilgin , Schrezenmeier Eva , Duettmann Wiebke , Weber Ulrike , Naik Marcel , Lehner Lukas Johannes , Kahl Andreas , Duerr Michael , Eckardt Kai-Uwe , Waiser Johannes , Choi Mira , Halleck Fabian
Published: May 2022

Graphical Abstract
Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review
Authors: Fard Amir , Pearson Robert , Lathan Rashida , Mark Patrick B. , Clancy Marc J.
Published: May 2022

Ex-vivo normothermic perfusion (EVNP) is an emerging strategy in kidney preservation that enables resuscitation and viability assessment under pseudo-physiological conditions prior to transplantation. The optimal perfusate composition and duration, however, remain undefined. A systematic literature search (Embase; Medline; Scopus; and BIOSIS Previews) was conducted. We identified 1,811 unique articles dating from January 1956 to July 2021, from which 24 studies were deemed eligible for qualitative analysis. The perfusate commonly used in clinical practice consisted of leukocyte-depleted, packed red blood cells suspended in Ringer’s lactate solution with Mannitol, dexamethasone, heparin, sodium bicarbonate and a specific nutrient solution supplemented with insulin, glucose, multivitamins and vasodilators. There is increasing support in preclinical studies for non-blood cell-based perfusates, including Steen solution, synthetic haem-based oxygen carriers and acellular perfusates with supraphysiological carbogen mixtures that support adequate oxygenation whilst also enabling gradual rewarming. Extended durations of perfusion (up to 24 h) were also feasible in animal models. Direct comparison between studies was not possible due to study heterogeneity. Current evidence demonstrates safety with the aforementioned widely used protocol, however, extracellular base solutions with adequate oxygenation, supplemented with nutrient and metabolic substrates, show promise by providing a suitable environment for prolonged preservation and resuscitation.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021231381, identifier PROSPERO 2021 CRD42021231381
BNT162b2 Third Booster Dose Significantly Increases the Humoral Response Assessed by Both RBD IgG and Neutralizing Antibodies in Renal Transplant Recipients
Authors: Hod Tammy , Ben-David Aharon , Olmer Liraz , Scott Noa , Ghinea Ronen , Mor Eytan , Levy Itzchak , Indenbaum Victoria , Lustig Yaniv , Grossman Ehud , Rahav Galia
Published: May 2022

Graphical Abstract
Role of the Intramural Vascular Network of the Extrahepatic Bile Duct for the Blood Circulation in the Recipient Extrahepatic Bile Duct Used for Duct-to-Duct-Biliary-Anastomosis in Living Donor Liver Transplantation
Authors: Yamaguchi Naotaka , Matsuyama Ryusei , Kikuchi Yutaro , Sato Sho , Yabushita Yasuhiro , Sawada Yu , Homma Yuki , Kumamoto Takafumi , Takeda Kazuhisa , Morioka Daisuke , Endo Itaru , Shimada Hiroshi
Published: May 2022

Graphical Abstract
Hyperammonemia After Lung Transplantation: Systematic Review and a Mini Case Series
Authors: Kamel Amir Y. , Emtiazjoo Amir M. , Adkins Lauren , Shahmohammadi Abbas , Alnuaimat Hassan , Pelaez Andres , Machuca Tiago , Pipkin Mauricio , Lee Hyun-wook , Weiner I. David , Chandrashekaran Satish
Published: May 2022

Background: Hyperammonemia after lung transplantation (HALT) is a rare but serious complication with high mortality. This systematic review delineates possible etiologies of HALT and highlights successful strategies used to manage this fatal complication.

Methods: Seven biomedical databases and grey literature sources were searched using keywords relevant to hyperammonemia and lung transplantation for publications between 1995 and 2020. Additionally, we retrospectively analyzed HALT cases managed at our institution between January 2016 and August 2018.

Results: The systematic review resulted in 18 studies with 40 individual cases. The mean peak ammonia level was 769 μmol/L at a mean of 14.1 days post-transplant. The mortality due to HALT was 57.5%. In our cohort of 120 lung transplants performed, four cases of HALT were identified. The mean peak ammonia level was 180.5 μmol/L at a mean of 11 days after transplantation. HALT in all four patients was successfully treated using a multimodal approach with an overall mortality of 25%.

Conclusion: The incidence of HALT (3.3%) in our institution is comparable to prior reports. Nonetheless, ammonia levels in our cohort were not as high as previously reported and peaked earlier. We attributed these significant differences to early recognition and prompt institution of multimodal treatment approach.
Survival After Lung Transplantation for Chronic Hypersensitivity Pneumonitis: Results From a Large International Cohort Study
Authors: Nosotti Mario , Leiva-Juarez Miguel , D’Ovidio Frank , Van Raemdonck Dirk , Ceulemans Laurens , Keshavjee Shaf , Rackauskas Mindaugas , Paladini Piero , Luzzi Luca , Casado Paula Moreno , Alvarez Antonio , Inci Ilhan , Ehrsam Jonas , Krueger Thorsten , Roth Andrey , Rea Federico , Schiavon Marco , Rosso Lorenzo
Published: May 2022

Repeated exposure to antigens via inhalation is the primary cause of hypersensitivity pneumonitis, a form of interstitial pneumonia. The chronic form of hypersensitivity pneumonitis leads to progressive loss of respiratory function; lung transplantation is the only therapeutic option for chronically ill patients. The ESTS Lung Transplantation Working Group conducted a retrospective multicentred cohort study to increase the body of knowledge available on this rare indication for lung transplantation. Data were collected for every patient who underwent lung transplant for hypersensitivity pneumonitis in participating centres between December 1996 and October 2019. Primary outcome was overall survival; secondary outcome was freedom from chronic lung allograft dysfunction. A total of 114 patients were enrolled from 9 centres. Almost 90% of patients were diagnosed with hypersensitivity pneumonitis before transplantation, yet the antigen responsible for the infection was identified in only 25% of cases. Eighty per cent of the recipients received induction therapy. Survival at 1, 3, and 5 years was 85%, 75%, and 70%, respectively. 85% of the patients who survived 90 days after transplantation were free from chronic lung allograft dysfunction after 3 years. The given study presents a large cohort of HP patients who underwent lung transplants. Overall survival rate is higher in transplanted hypersensitivity pneumonitis patients than in those suffering from any other interstitial lung diseases. Hypersensitivity pneumonitis patients are good candidates for lung transplantation.
Interannual Variability of Summer Hotness in China: Synergistic Effect of Frequency and Intensity of High Temperature
Authors: Zhang Wenyan , Lu Er , Tu Juqing , Chao Qingchen , Wang Hui
Published: May 2022

In the context of global warming, the impact of summer high temperature events is increasing. The accumulated summer high temperature is often used to reflect the overall hotness of summer. The internal variation of the accumulated temperature can be affected by both the frequency and intensity. In this study, by using the daily data during summers of 1960–2018, we examine the relative importance of the two factors with a multiple linear regression method. It is demonstrated that that the dominant result of summer accumulated temperature is sensitive to the change of threshold. As the threshold increases, the importance of frequency gradually increases, while the importance of the intensity decreases. In addition, it is found that when the threshold changes, the sensitivity of the dominant results is different over regions. This can provide a basis for the selection of regional thresholds and further improve the representation of accumulated temperature for high summer temperatures.
The Umbrella Type Canopy Increases Tolerance to Abiotic Stress-Leaf Microenvironment Temperature and Tropospheric Ozone in ‘Chambourcin’
Authors: Li Xinfeng , Li Shangrui , Zhang Yifan , Huang Wenwei , Zhu Huaping , Zhai Heng , Gao Zhen , Du Yuanpeng
Published: May 2022

This study reports on the effect of the vertical shoot type canopy (VST) and umbrella type canopy (UT) on the fruit region microenvironment, light interception, tropospheric ozone, and berry quality of vertical trellis ‘Chambourcin’. The real-time temperature and humidity fluctuation and the daily average temperature of the UT canopy were lower than that of the VST canopy. An extremely high temperature was recorded around the fruit region of the VST canopy. Notably, the UT canopy significantly increased light interception and leaf area index and reduced the damage of atmospheric ozone to the leaves. These phenomena increased the content of soluble solids, anthocyanins, total phenols, flavonoids, and flavanols in the mature fruits of the UT canopy more than in the VST canopy. In conclusion, the UT canopy saves shoot management labor and improves the fruit region’s microenvironment and the content of anthocyanins, total phenols, flavonoids, and flavanols.
Latest Contributions of Genomics to T-Cell Acute Lymphoblastic Leukemia (T-ALL)
Authors: Genescà Eulàlia , González-Gil Celia
Published: May 2022

As for many neoplasms, initial genetic data about T-cell acute lymphoblastic leukemia (T-ALL) came from the application of cytogenetics. This information helped identify some recurrent chromosomal alterations in T-ALL at the time of diagnosis, although it was difficult to determine their prognostic impact because of their low incidence in the specific T-ALL cohort analyzed. Genetic knowledge accumulated rapidly following the application of genomic techniques, drawing attention to the importance of using high-resolution genetic techniques to detect cryptic aberrations present in T-ALL, which are not usually detected by cytogenetics. We now have a clearer appreciation of the genetic landscape of the different T-ALL subtypes at diagnosis, explaining the particular oncogenetic processes taking place in each T-ALL, and we have begun to understand relapse-specific mechanisms. This review aims to summarize the latest advances in our knowledge of the genome in T-ALL. We highlight areas where the research in this subtype of ALL is progressing with the aim of identifying key questions that need to be answered in the medium-long term if this knowledge is to be applied in clinics.
Trends and Determinants in Uptake of Cervical Cancer Screening in Spain: An Analysis of National Surveys from 2017 and 2020
Authors: Portero de la Cruz Silvia , Cebrino Jesús
Published: May 2022

Cervical cancer rates have declined in industrialized nations as a result of cytology screening programs. However, there are still sizeable differences in screening adherence in Spain. This study aimed to identify the prevalence of cervical cancer screening among women in Spain, to analyze trends in that prevalence from 2017 and 2020 and to identify socio-demographic, health, and lifestyle factors related with adherence to this screening test. We conducted a cross-sectional study of 13,619 women aged 25–65 who participated in the 2017 Spanish National Health Survey and the 2020 European Health Survey for Spain. We used logistic regression to examine the relationship between socio-demographic, health and lifestyle factors and cervical cancer adherence. The prevalence of adherence was 73.18%. Additionally, there was a significant decrease in cervical cancer screening uptake from 2017 and 2020 among women aged 25–44 years (2017: 77.80%, 2020: 75.20%, p = 0.02), but an increase in the age group of 45–65 years (2017: 68.93%, 2020: 72.39%, p < 0.01) and in foreigners (2017: 64.29%, 2020: 72.29%, p < 0.01). Screening for cervical cancer is related with age, educational level, social class, insurance status, visits to the family doctor, alcohol consumption and free time physical exercise.
Two-Front War on Cancer—Targeting TAM Receptors in Solid Tumour Therapy
Authors: Mikolajczyk Agata , Mitula Filip , Popiel Delfina , Kaminska Bozena , Wieczorek Maciej , Pieczykolan Jerzy
Published: May 2022

Receptor tyrosine kinases (RTKs) are transmembrane receptors that bind growth factors and cytokines and contain a regulated kinase activity within their cytoplasmic domain. RTKs play an important role in signal transduction in both normal and malignant cells, and their encoding genes belong to the most frequently affected genes in cancer cells. The TAM family proteins (TYRO3, AXL, and MERTK) are involved in diverse biological processes: immune regulation, clearance of apoptotic cells, platelet aggregation, cell proliferation, survival, and migration. Recent studies show that TAMs share overlapping functions in tumorigenesis and suppression of antitumour immunity. MERTK and AXL operate in innate immune cells to suppress inflammatory responses and promote an immunosuppressive tumour microenvironment, while AXL expression correlates with epithelial-to-mesenchymal transition, metastasis, and motility in tumours. Therefore, TAM RTKs represent a dual target in cancer due to their intrinsic roles in tumour cell survival, migration, chemoresistance, and their immunosuppressive roles in the tumour microenvironment (TME). In this review, we discuss the potential of TAMs as emerging therapeutic targets in cancer treatment. We critically assess and compare current approaches to target TAM RTKs in solid tumours and the development of new inhibitors for both extra- and intracellular domains of TAM receptor kinases.
iMIL4PATH: A Semi-Supervised Interpretable Approach for Colorectal Whole-Slide Images
Authors: Neto Pedro C. , Oliveira Sara P. , Montezuma Diana , Fraga João , Monteiro Ana , Ribeiro Liliana , Gonçalves Sofia , Pinto Isabel M. , Cardoso Jaime S.
Published: May 2022

Colorectal cancer (CRC) diagnosis is based on samples obtained from biopsies, assessed in pathology laboratories. Due to population growth and ageing, as well as better screening programs, the CRC incidence rate has been increasing, leading to a higher workload for pathologists. In this sense, the application of AI for automatic CRC diagnosis, particularly on whole-slide images (WSI), is of utmost relevance, in order to assist professionals in case triage and case review. In this work, we propose an interpretable semi-supervised approach to detect lesions in colorectal biopsies with high sensitivity, based on multiple-instance learning and feature aggregation methods. The model was developed on an extended version of the recent, publicly available CRC dataset (the CRC+ dataset with 4433 WSI), using 3424 slides for training and 1009 slides for evaluation. The proposed method attained 90.19% classification ACC, 98.8% sensitivity, 85.7% specificity, and a quadratic weighted kappa of 0.888 at slide-based evaluation. Its generalisation capabilities are also studied on two publicly available external datasets.
Interactions of Cr3+, Ni2+, and Sr2+ with Crushed Concrete Fines
Authors: Hurt Andrew P. , Coleman Aimee A. , Coleman Nichola J.
Published: May 2022

The underutilized cement-rich fine fraction of concrete-based demolition waste is a potential sorbent for aqueous metal ion contaminants. In this study, crushed concrete fines (CCF) were found to exclude 33.9 mg g−1 of Cr3+, 35.8 mg g−1 of Ni2+, and 7.16 mg g−1 of Sr2+ from ~1000 ppm single metal nitrate solutions (CCF:solution 25 mg cm−3) under static batch conditions at 20 °C after 3 weeks. The removal of Sr2+ followed a pseudo-second-order reaction (k2 = 3.1 × 10−4 g mg−1 min−1, R2 = 0.999), whereas a pseudo-first-order model described the removal of Cr3+ (k1 = 2.3 × 10−4 min−1, R2 = 0.998) and Ni2+ (k1 = 5.7 × 10−4 min−1, R2 = 0.991). In all cases, the principal mechanism of interaction was the alkali-mediated precipitation of solubility-limiting phases on the surface of the CCF. Four consecutive deionized water leaching procedures (CCF:water 0.1 g cm−3) liberated 0.53%, 0.88%, and 8.39% of the bound Cr3+, Ni2+, and Sr2+ species, respectively. These findings indicate that CCF are an effective sorbent for the immobilization and retention of aqueous Cr3+ and Ni2+ ions, although they are comparatively ineffectual in the removal and sustained exclusion of Sr2+ ions. As is commonly noted with Portland cement-based sorbents, slow removal kinetics, long equilibrium times, the associated release of Ca2+ ions, high pH, and the formation of loose floc may preclude these materials from conventional wastewater treatments. This notwithstanding, they are potentially suitable for incorporation into permeable reactive barriers for the containment of metal species in contaminated groundwaters, sediments, and soils.
Experimental and Numerical Analysis of Progressive Damage of SiCf/SiC Composite under Three-Point Bending
Authors: Li Xiang , Luo Ruiying
Published: May 2022

Satin SiCf/SiC composite has a wide range of applications; it is necessary to study its mechanical properties. The progressive failure of five-harness five-layer satin weave SiCf/SiC plate composites was explored experimentally and numerically in this research. The bending properties were derived and elucidated at ambient temperature through a three-point bending experiment. The generation and progression of damage was observed by CCD camera. For quantitative analysis of the strain field evolution, DIC (digital image correlation) was adopted, while the microscopic analyses were performed for the description of the derived failure markings. With the aid of ABAQUS/Explicit, the experiment was subjected to 3D finite element modeling for the reproduction of the material behavioral, where the VUMAT subroutine was used to implement a 3D-altered criterion of the Hashin damage initiation and the progression law of its complementary damage. Intra-deformation interface failure was simulated with a composite interlayer cohesive zone element. The experimentally derived DIC-based strain fields were well-consistent with the numerical outcomes. Deeper investigation was made into the superiority of the 3D modeling, which is ascribed to the predictability for distribution of complex field variables like the free-edge effect and progressive failure accumulation within the critical sample section. The damage mechanism of the satin weave composite was explored in depth and it provides useful guidance for the practical application of the composite.
A New Approach to Energy Transition in Morocco for Low Carbon and Sustainable Industry (Case of Textile Sector)
Authors: Smouh Slimane , Gargab Fatima Zohra , Ouhammou Badr , Mana Abdel Ali , Saadani Rachid , Jamil Abdelmajid
Published: May 2022

Morocco has resolutely committed to the green transition of its economy by opting for industry decarbonation, which now imposes itself as an essential access criterion to foreign markets. Intending to include energy efficiency in the leading players in energy-intensive industries, this paper has the main objective of contributing to a better understanding of the decarbonation plans potential impact, taking the example of solar energy integrating opportunities as an action for a thrifty, sustainable, and low carbon Moroccan industry. Indeed, the paper focuses on the industrial textile sector, such as the energy-intensive industry. This sector is the first employer and the most important industrial activity; it is also an icon and the oldest industry in Morocco. This study examines the energy, economic and environmental fallout, evaluating the productions, the investment and the CO2 emissions limit. Besides, the energy industrial sector is characterized by a strong dependence on fossil imports, which increases the energy factor and price. In this regard, several geographical sites and factories were studied under six climatic regional conditions, proposing the most optimal and sustainable configurations for each location and present models with scopes and levels of energy and environment gains and investments that can inspire the sector actors. Then the present work must install concepts by inspiring local factories, accompanying the national vision, and resizing the industrial ecology. In this paper, a power of 8.88 MW is the total power installed, which provides an annual total of 8484.65 tonnes of CO2, with an average payback time between 2.6 years and 4.5 years, and attractive economic parameters, with an LCOE of 0.034 $/kWh and $181,863 for the NPC, those outputs shows the importance of environmental gains that the generalization of this strategic vision can achieve.
Compatible Biomass Model of Moso Bamboo with Measurement Error
Authors: Zhou Xiao , Zheng Yaxiong , Guan Fengying , Xiao Xiao , Zhang Xuan , Li Chengji
Published: May 2022

Moso bamboo is characterized by its fast growth and high yield and is important as a carbon sink species. Therefore, understanding the biomass distribution of its components is crucial. Based on the measured individual biomass data of 66 Phyllostachys heterocycla cv. Pubescens plants in the Yixing state-owned forest in Jiangsu Province, nonlinear simultaneous equations with measurement errors were constructed using nonlinear error-in-variable models (NEIVM) (one step, two step) and nonlinear seemingly unrelated regression (NSUR). Variables affecting biomass were evaluated, including diameter at breast height (DBH), bamboo height (H), height to crown base (HCB), node length at DBH (NL), base diameter (BD), and bamboo age (A). DBH, H, and HCB had significant effects on the biomass of each component. They were used to construct a one-predictor system using DBH, a two-predictor system using DBH and H, and a three-predictor system using DBH, H, and HCB. Regardless of the number of variables used, the fitting accuracy of the NEIVM one-step method exceeded that of the two-step method, and that of NEIVM exceeded that of NSUR estimation. As a system using three predictive variables is better than other systems, we recommend using the one-step NEIVM method for Moso bamboo biomass estimation.
Ecosystem Carbon Stocks and Their Annual Sequestration Rate in Mature Forest Stands on the Mineral Soils of Estonia
Authors: Kõlli Raimo , Kauer Karin , Tõnutare Tõnu , Lutter Reimo
Published: May 2022

Mature forest ecosystems are the most considerable reservoir of organic carbon (OC) among terrestrial ecosystems. The effect of soil type on aboveground OC stocks and their annual increases (AI) of overstorey tree, understorey tree and ground vegetation layers in Estonian forest phytocoenoses with mature stands on mineral soils were studied. The study enfolds nine mineral soil groups, which are characterized by their phytocoenoses composition, soil cover properties and tree stands’ taxation data. An assemblage of soil and plant cover or plant–soil system is the main focus point in explaining causal and quantitative sides of ecosystems functioning. Surface densities of OC stocks in aboveground phytomass of forests varied significantly in the range of 52–100 Mg OC ha−1. High AI or productivity (4.8–5.5 Mg OC ha−1 year−1) is a characteristic of forest ecosystems formed on leached, eluviated and pseudopodzolic soils. Forest ecosystem ground vegetation, which is an important ecological indicator, fulfils vacant ecological niches with herbs and/or mosses (up to 0.50 Mg OC ha−1). The variation of ecosystem OC stocks and their AI by soil type should be taken into account in regional OC stocks and its annual increase estimations.
Distributed Bandwidth Allocation Strategy for QoE Fairness of Multiple Video Streams in Bottleneck Links
Authors: Liu Yazhi , Wei Dongyu , Zhang Chunyang , Li Wei
Published: May 2022

In QoE fairness optimization of multiple video streams, a distributed video stream fairness scheduling strategy based on federated deep reinforcement learning is designed to address the problem of low bandwidth utilization due to unfair bandwidth allocation and the problematic convergence of distributed algorithms in cooperative control of multiple video streams. The proposed strategy predicts a reasonable bandwidth allocation weight for the current video stream according to its player state and the global characteristics provided by the server. Then the congestion control protocol allocates the proportion of available bandwidth, matching its bandwidth allocation weight to each video stream in the bottleneck link. The strategy trains a local predictive model on each client and periodically performs federated aggregation to generate the optimal global scheme. In addition, the proposed strategy constructs global parameters containing information about the overall state of the video system to improve the performance of the distributed scheduling algorithm. The experimental results show that the introduction of global parameters can improve the algorithm’s QoE fairness and overall QoE efficiency by 10% and 8%, respectively. The QoE fairness and overall QoE efficiency are improved by 8% and 7%, respectively, compared with the latest scheme.
A Model of Trust
Authors: Bellucci Gabriele
Published: May 2022

Trust is central to a large variety of social interactions. Different research fields have empirically and theoretically investigated trust, observing trusting behaviors in different situations and pinpointing their different components and constituents. However, a unifying, computational formalization of those diverse components and constituents of trust is still lacking. Previous work has mainly used computational models borrowed from other fields and developed for other purposes to explain trusting behaviors in empirical paradigms. Here, I computationally formalize verbal models of trust in a simple model (i.e., vulnerability model) that combines current and prospective action values with beliefs and expectancies about a partner’s behavior. By using the classic investment game (IG)—an economic game thought to capture some important features of trusting behaviors in social interactions—I show how variations of a single parameter of the vulnerability model generates behaviors that can be interpreted as different “trust attitudes”. I then show how these behavioral patterns change as a function of an individual’s loss aversion and expectations of the partner’s behavior. I finally show how the vulnerability model can be easily extended in a novel IG paradigm to investigate inferences on different traits of a partner. In particular, I will focus on benevolence and competence—two character traits that have previously been described as determinants of trustworthiness impressions central to trust. The vulnerability model can be employed as is or as a utility function within more complex Bayesian frameworks to fit participants’ behavior in different social environments where actions are associated with subjective values and weighted by individual beliefs about others’ behaviors. Hence, the vulnerability model provides an important building block for future theoretical and empirical work across a variety of research fields.
Genetic Diversity and Population Structure of Fusarium commune Causing Strawberry Root Rot in Southcentral China
Authors: He Yunlu , Chen Jia , Tang Chao , Deng Qiao , Guo Litao , Cheng Yi , Li Zhimin , Wang Tuhong , Xu Jianping , Gao Chunsheng
Published: May 2022

Strawberry plants and fruits are vulnerable to infections by a broad range of pathogens and pests. However, knowledge about the epidemiology of pathogens causing strawberry diseases is limited. In this study, we analyzed Fusarium commune, a major fungal pathogen causing strawberry root rot, from diseased strawberry root tissues in southcentral China. A total of 354 isolates were obtained from 11 locations that spanned about 700 km from both south to north and east to west. Multilocus genotypes of all isolates were obtained using seven polymorphic simple sequence repeat markers developed in this study. Our analyses revealed significant genetic diversity within each of the 11 local populations of F. commune. STRUCTURE analysis revealed that the optimal number of genetic populations for the 354 strains was two, with most local geographic populations containing isolates in both genetic clusters. Interestingly, many isolates showed allelic ancestry to both genetic clusters, consistent with recent hybridization between the two genetic clusters. In addition, though alleles and genotypes were frequently shared among local populations, statistically significant genetic differentiations were found among the local populations. However, the observed F. commune population genetic distances were not correlated with geographic distances. Together, our analyses suggest that populations of F. commune causing strawberry root rot are likely endemic to southcentral China, with each local population containing shared and unique genetic elements. Though the observed gene flow among geographic regions was relatively low, human activities will likely accelerate pathogen dispersals, resulting in the generation of new genotypes through mating and recombination.
Genome-Wide Identification, Characterization, and Expression Profiling Analysis of SPL Gene Family during the Inflorescence Development in Trifolium repens
Authors: Ma Jieyu , Nie Gang , Yang Zhongfu , Ma Sainan , Fan Jinwan , Hu Ruchang , Wu Feifei , Zhang Xinquan
Published: May 2022

Trifolium repens is the most widely cultivated perennial legume forage in temperate region around the world. It has rich nutritional value and good palatability, seasonal complementarity with grasses, and can improve the feed intake and digestibility of livestock. However, flowering time and inflorescence development directly affects the quality and yield of T. repens, as well as seed production. The Squa promoter binding protein-like (SPL) gene family is a plant specific transcription factor family, which has been proved to play a critical role in regulating plant formation time and development of flowers. In this study, a total of 37 TrSPL genes were identified from the whole genome of T. repens and were divided into nine clades based on phylogenetic tree. Seventeen TrSPL genes have potential target sites for miR156. The conserved motif of squamosa promoter binding protein (SBP) contains two zinc finger structures and one NLS structure. Gene structure analysis showed that all TrSPL genes contained SBP domain, while ankyrin repeat region was just distributed in part of genes. 37 TrSPL genes were relatively dispersedly distributed on 16 chromosomes, and 5 pairs of segmental repeat genes were found, which indicated that segmental duplication was the main way of gene expansion. Furthermore, the gene expression profiling showed that TrSPL11, TrSPL13, TrSPL22, and TrSPL26 were highly expressed only in the early stage of inflorescence development, while TrSPL1 and TrSPL6 are highly expressed only in the mature inflorescence. Significantly, the expression of TrSPL4 and TrSPL12 increased gradually with the development of inflorescences. The results of this study will provide valuable clues for candidate gene selection and elucidating the molecular mechanism of T. repens flowering regulation.
Selection and Validation of Reference Genes for RT-qPCR Analysis in Tibetan Medicinal Plant Saussurea Laniceps Callus under Abiotic Stresses and Hormone Treatments
Authors: Liu Huan , Lu Yaning , Wang Xiaojing , Wang Xiaowei , Li Rongchen , Lu Cunfu , Lan Xiaozhong , Chen Yuzhen
Published: May 2022

Real-time quantitative PCR (RT-qPCR) is an important technique for studying gene expression analysis, but accurate and reliable results depend on the use of a stable reference gene. This study proposes to test the expression stability of candidate reference genes in the callus of Saussurea laniceps, a unique Tibetan medicinal plant. Based on the S. laniceps callus transcriptome, eleven candidate reference genes, including TUA2, TUB3, TUB8, TIF3B1, TIF3H1, ELF5A, PP2AA2, UEV1D, UBL5, UBC36, and SKIP1), were validated for RT-qPCR normalization in the callus under abiotic stress (salt, cold, and UV) and hormone treatments (abscisic acid, MeJA, and salicylic acid). The stability of the candidate genes was evaluated in all the samples of S. laniceps. Comprehensive analysis of all samples showed that the best reference genes were UBC36 and UBL5. ELF5A and TIF3B1 were ranked as the most stable genes in the sample sets under abiotic stress. For hormone stimulation, UBC36 and TIF3H1 genes had the best stability. This study provides useful guidelines and a starting point for reference gene selection for expression analysis using RT-qPCR techniques in S. laniceps.
Increased Knowledge of Adult-Onset Dystonia Amongst Medical Students via Brief Video Education: A Systematic Review and Cohort Study
Authors: Khan Sana , Sowemimo Nina , Alty Jane , Cosgrove Jeremy
Published: May 2022

Most doctors have limited knowledge of dystonia, a movement disorder that can affect people of all ages; this contributes to diagnostic delay and poor quality of life. We investigated whether a brief educational intervention could improve knowledge of dystonia amongst medical students. We conducted a systematic review on undergraduate knowledge of dystonia and created an eight-minute video on the condition. We invited medical students at the University of Leeds, UK, to answer 15 multiple choice questions before and immediately after watching the video, and again one month later. Only one previous study specifically assessed medical students’ knowledge of dystonia whilst five others tested their knowledge of movement disorders, or neurology generally, with some questions on dystonia. Of the University of Leeds medical students, 87 (100%), 77 (89%) and 40 (46%) completed the baseline, immediate-recall and delayed-recall questionnaires, respectively. The mean score for students who completed all three questionnaires increased from 7.7 (out of 15) to 12.5 on the immediate-recall questionnaire (p < 0.001), and to 10.1 on the delayed-recall questionnaire (p < 0.001). At baseline, 76% of students rated their confidence in recognising dystonia as low. After watching the video, 78% rated their confidence as a high, and none rated it low. A brief video improved their knowledge substantially, with sustained effects. This method could be incorporated into medical curricula to reduce diagnostic delays.
Patient Satisfaction with Telemedicine during the COVID-19 Pandemic—A Systematic Review
Authors: Pogorzelska Karolina , Chlabicz Slawomir
Published: May 2022

Telemedicine is a convenient tool for providing medical care remotely. It is routinely offered as an alternative to face-to-face consultations in healthcare settings all over the world. Due to the COVID-19 pandemic and increased use of telemedicine in everyday clinical practice, the effectiveness of this modality and patient satisfaction with telemedicine is a subject of growing concern. PubMed and Google Scholar databases were searched. Papers published between January 2020 and August 2021 which met inclusion and exclusion criteria were analyzed. During the COVID-19 pandemic patients have found telemedicine a beneficial tool for consulting healthcare providers. A high level of satisfaction with telehealth was observed in each study across every medical specialty. Telemedicine is undoubtedly a convenient tool that has helped ensure continuity of medical care during the COVID-19 pandemic thanks to its considerable potential. In particular situations, telehealth may adequately replace face-to-face consultation. Regular patients’ feedback is necessary to improve the use of telemedicine in the future.
Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis
Authors: Aspinall Sean A. , Mackintosh Kelly A. , Hill Denise M. , Cope Bethany , McNarry Melitta A.
Published: May 2022

Background: Modulator therapy represents a significant step forward in CF care and is expected to have a significant impact on the health and mortality of many individuals with CF. Studies have predominantly explored the physiological effects of modulator therapy on clinical outcomes, with little consideration of the individual lived experience of modulator therapy among adults with Cystic Fibrosis. Methods: To explore this, semi-structured interviews were conducted with 12 individuals currently taking Kaftrio, which were subsequently thematically analysed. Results: Three overarching themes were identified: (i) positive perception of Kaftrio, (ii) negative perception of Kaftrio, and (iii) the relationships with the clinical team. The experience of modulator therapy should be recognised as being unique to the individual, with perceptions of illness, self-identity, and outcomes strongly dictating the lived experience. Conclusions: There is a consensus that, while for many, the quality of life is evidently increased through the use of Kaftrio, this is not without its own challenges. This highlights the need for both individuals with CF and their clinical teams to learn to navigate this new disease landscape.
Assessing the Soundscape Appropriateness in the Vicinity of a Heliport in an Urban Park of Quito (Ecuador) Using Immersive Audio-Visual Scenarios
Authors: Puyana-Romero Virginia , Cueto José Luis , Caizapasto-Sánchez Ismael Sebastián , Marcillo-Calispa Gabriel Eduardo
Published: May 2022

Heliports are facilities that play a fundamental role in security and emergency operations. Since rotorcrafts do not need much space for take-off and landing, heliports are normally immersed in the urban fabric of our cities. However, they generate high noise levels, which can cause a nuisance, especially in outdoor areas intended for the recreation of citizens. This paper studies how helicopter noise affects the perception of the soundscape appropriateness and landscape quality in the vicinity of a heliport located in an urban park, using semantic differential scales and appraisals on the noise sources. The study area was the “Parque del Bicentenario” in Quito, Ecuador. Immersive Virtual Reality (IVR) laboratory tests using 360-degree videos and spatial audio were preferred to on-site questionnaires, given the difficulty of predicting when helicopter noise events would occur. For the statistical analysis, objective acoustic and psychoacoustic parameters have also been considered. Results show that the soundscape is perceived as more pleasant and less chaotic when there is no helicopter noise. Furthermore, with the same visual stimuli, the appraisals of the landscape are much better in the scenarios without the helicopter noise. Sharpness is the psychoacoustic parameter that best explains the variance of the subjective variables evaluated.
Mitigation Planning and Policies Informed by COVID-19 Modeling: A Framework and Case Study of the State of Hawaii
Authors: Lee Thomas H. , Do Bobby , Dantzinger Levi , Holmes Joshua , Chyba Monique , Hankins Steven , Mersereau Edward , Hara Kenneth , Fan Victoria Y.
Published: May 2022

In the face of great uncertainty and a global crisis from COVID-19, mathematical and epidemiologic COVID-19 models proliferated during the pandemic. Yet, many models were not created with the explicit audience of policymakers, the intention of informing specific scenarios, or explicit communication of assumptions, limitations, and complexities. This study presents a case study of the roles, uses, and approaches to COVID-19 modeling and forecasting in one state jurisdiction in the United States. Based on an account of the historical real-world events through lived experiences, we first examine the specific modeling considerations used to inform policy decisions. Then, we review the real-world policy use cases and key decisions that were informed by modeling during the pandemic including the role of modeling in informing planning for hospital capacity, isolation and quarantine facilities, and broad public communication. Key lessons are examined through the real-world application of modeling, noting the importance of locally tailored models, the role of a scientific and technical advisory group, and the challenges of communicating technical considerations to a public audience.
Preventive Counseling in Routine Prenatal Care—A Qualitative Study of Pregnant Women’s Perspectives on a Lifestyle Intervention, Contrasted with the Experiences of Healthcare Providers
Authors: Lorenz Laura , Krebs Franziska , Nawabi Farah , Alayli Adrienne , Stock Stephanie
Published: May 2022

Maternal lifestyle during pregnancy and excessive gestational weight gain can influence maternal and infant short and long-term health. As part of the GeMuKi intervention, gynecologists and midwives provide lifestyle counseling to pregnant women during routine check-up visits. This study aims to understand the needs and experiences of participating pregnant women and to what extent their perspectives correspond to the experiences of healthcare providers. Semi-structured interviews were conducted with 12 pregnant women and 13 multi-professional healthcare providers, and were analyzed using qualitative content analysis. All interviewees rated routine check-up visits as a good setting in which to focus on lifestyle topics. Women in their first pregnancies had a great need to talk about lifestyle topics. None of the participants were aware of the link between gestational weight gain and maternal and infant health. The healthcare providers interviewed attributed varying relevance regarding the issue of weight gain and, accordingly, provided inconsistent counseling. The pregnant women expressed dissatisfaction regarding the multi-professional collaboration. The results demonstrate a need for strategies to improve multi-professional collaboration. In addition, health care providers should be trained to use sensitive techniques to inform pregnant women about the link between gestational weight gain and maternal and infant health.
Modeling and Preliminary Analysis of the Impact of Meteorological Conditions on the COVID-19 Epidemic
Authors: Sun Chenglong , Chao Liya , Li Haiyan , Hu Zengyun , Zheng Hehui , Li Qingxiang
Published: May 2022

Since the COVID-19 epidemic outbreak at the end of 2019, many studies regarding the impact of meteorological factors on the attack have been carried out, and inconsistent conclusions have been reached, indicating the issue’s complexity. To more accurately identify the effects and patterns of meteorological factors on the epidemic, we used a combination of logistic regression (LgR) and partial least squares regression (PLSR) modeling to investigate the possible effects of common meteorological factors, including air temperature, relative humidity, wind speed, and surface pressure, on the transmission of the COVID-19 epidemic. Our analysis shows that: (1) Different countries and regions show spatial heterogeneity in the number of diagnosed patients of the epidemic, but this can be roughly classified into three types: “continuous growth”, “staged shock”, and “finished”; (2) Air temperature is the most significant meteorological factor influencing the transmission of the COVID-19 epidemic. Except for a few areas, regional air temperature changes and the transmission of the epidemic show a significant positive correlation, i.e., an increase in air temperature is conducive to the spread of the epidemic; (3) In different countries and regions studied, wind speed, relative humidity, and surface pressure show inconsistent correlation (and significance) with the number of diagnosed cases but show some regularity.
Sustainable Working Life in Intensive Care: A Qualitative Study of Older Nurses
Authors: Sousa-Ribeiro Marta , Lindfors Petra , Knudsen Katinka
Published: May 2022

To counteract the shortage of nurses in the workforce, healthcare organizations must encourage experienced nurses to extend their working lives. Intensive care (IC) has higher nurse-to-patient ratios than other settings, which includes a particular susceptibility to staff shortage. This qualitative study investigated how older IC nurses experienced their working life and their reflections on the late-career and retirement. Semi-structured interviews with 12 IC nurses in Sweden (aged 55–65 years) were analyzed using an interpretative phenomenological analysis approach. The results showed that nurses planned to continue working until the age of 65 and beyond. When reflecting on their late-career decisions, nurses considered nine areas covering individual, work, and organizational factors as being central to their ability and willingness to stay. Overall, the nurses had good health and were very satisfied and committed to their job and to the organization. They mentioned having both the job and personal resources required to cope with the physical and mental job demands, which were perceived as motivational challenges, rather than hinders. They also reflected on various human resource management practices that may promote aging-in-workplace. These findings may inform organizations aiming at providing adequate conditions for enabling healthy and sustainable working lives for IC nurses.