bluuebunny/crossref_metadata_2025 huggingface dataset:
A comparative study of clinical trial and real-world data in patients with diabetic kidney disease
Authors: Kurki Samu , Halla-aho Viivi , Haussmann Manuel , Lähdesmäki Harri , Leinonen Jussi V. , Koskinen Miika
Published: January 2024

A growing body of research is focusing on real-world data (RWD) to supplement or replace randomized controlled trials (RCTs). However, due to the disparities in data generation mechanisms, differences are likely and necessitate scrutiny to validate the merging of these datasets. We compared the characteristics of RCT data from 5734 diabetic kidney disease patients with corresponding RWD from electronic health records (EHRs) of 23,523 patients. Demographics, diagnoses, medications, laboratory measurements, and vital signs were analyzed using visualization, statistical comparison, and cluster analysis. RCT and RWD sets exhibited significant differences in prevalence, longitudinality, completeness, and sampling density. The cluster analysis revealed distinct patient subgroups within both RCT and RWD sets, as well as clusters containing patients from both sets. We stress the importance of validation to verify the feasibility of combining RCT and RWD, for instance, in building an external control arm. Our results highlight general differences between RCT and RWD sets, which should be considered during the planning stages of an RCT-RWD study. If they are, RWD has the potential to enrich RCT data by providing first-hand baseline data, filling in missing data or by subgrouping or matching individuals, which calls for advanced methods to mitigate the differences between datasets.
Comparison of T2 values of the displaced unilateral disc and retrodiscal tissue of temporomandibular joints and their implications
Authors: Kakimoto Naoya , Wongratwanich Pongsapak , Shimamoto Hiroaki , Kitisubkanchana Jira , Tsujimoto Tomomi , Shimabukuro Kiichi , Verdonschot Rinus G. , Hasegawa Yoko , Murakami Shumei
Published: January 2024

Unilateral anterior disc displacement (uADD) has been shown to affect the contralateral joints qualitatively. This study aims to assess the quantitative T2 values of the articular disc and retrodiscal tissue of patients with uADD at 1.5 Tesla (T). The study included 65 uADD patients and 17 volunteers. The regions of interest on T2 maps were evaluated. The affected joints demonstrated significantly higher articular disc T2 values (31.5 ± 3.8 ms) than those of the unaffected joints (28.9 ± 4.5 ms) (P < 0.001). For retrodiscal tissue, T2 values of the unaffected (37.8 ± 5.8 ms) and affected joints (41.6 ± 7.1 ms) were significantly longer than those of normal volunteers (34.4 ± 3.2 ms) (P < 0.001). Furthermore, uADD without reduction (WOR) joints (43.3 ± 6.8 ms) showed statistically higher T2 values than the unaffected joints of both uADD with reduction (WR) (33.9 ± 3.8 ms) and uADDWOR (38.9 ± 5.8 ms), and the affected joints of uADDWR (35.8 ± 4.4 ms). The mean T2 value of the unaffected joints of uADDWOR was significantly longer than that of healthy volunteers (P < 0.001). These results provided quantitative evidence for the influence of the affected joints on the contralateral joints.
Mapping the diversity of land uses following deforestation across Africa
Authors: Masolele Robert N. , Marcos Diego , De Sy Veronique , Abu Itohan-Osa , Verbesselt Jan , Reiche Johannes , Herold Martin
Published: January 2024

African forest are increasingly in decline as a result of land-use conversion due to human activities. However, a consistent and detailed characterization and mapping of land-use change that results in forest loss is not available at the spatial-temporal resolution and thematic levels suitable for decision-making at the local and regional scales; so far they have only been provided on coarser scales and restricted to humid forests. Here we present the first high-resolution (5 m) and continental-scale mapping of land use following deforestation in Africa, which covers an estimated 13.85% of the global forest area, including humid and dry forests. We use reference data for 15 different land-use types from 30 countries and implement an active learning framework to train a deep learning model for predicting land-use following deforestation with an F1-score of $$84\pm 0.7$$

84
±
0.7

for the whole of Africa. Our results show that the causes of forest loss vary by region. In general, small-scale cropland is the dominant driver of forest loss in Africa, with hotspots in Madagascar and DRC. In addition, commodity crops such as cacao, oil palm, and rubber are the dominant drivers of forest loss in the humid forests of western and central Africa, forming an “arc of commodity crops” in that region. At the same time, the hotspots for cashew are found to increasingly dominate in the dry forests of both western and south-eastern Africa, while larger hotspots for large-scale croplands were found in Nigeria and Zambia. The increased expansion of cacao, cashew, oil palm, rubber, and large-scale croplands observed in humid and dry forests of western and south-eastern Africa suggests they are vulnerable to future land-use changes by commodity crops, thus creating challenges for achieving the zero deforestation supply chains, support REDD+ initiatives, and towards sustainable development goals.
Serious underestimation of reduced carbon uptake due to vegetation compound droughts
Authors: Song Jiaxi , Zhou Sha , Yu Bofu , Li Yan , Liu Yanxu , Yao Ying , Wang Shuai , Fu Bojie
Published: January 2024

Compound droughts with low soil moisture (SM) and high vapor pressure deficit (VPD) pose significant threats to terrestrial carbon sink and agricultural production. However, the frequency and intensity of compound droughts and their adverse impacts on the carbon cycle remain highly uncertain. Here, we define and identify vegetation compound droughts (VCDs) when low SM and high VPD severely limit and adversely affect vegetation carbon uptake. We find frequent and severe VCDs and their considerable adverse impacts on carbon uptake in mid- and low-latitude regions, particularly in drylands. Risks of VCDs have been greatly underestimated as the widely adopted quantile-based approach identifies only 11% of VCDs and 26% of global GPP anomalies due to VCDs. The frequency and intensity of VCDs and their adverse impacts on carbon uptake are projected to increase further, irrespective of whether the CO2 fertilization effect on vegetation growth and photosynthesis is considered or not. These findings improve our understanding of current and future risks of VCDs and underline the importance of adaptation measures to cope with the adverse impacts of ever-increasing compound droughts.
Reciprocal expression of MADS-box genes and DNA methylation reconfiguration initiate bisexual cones in spruce
Authors: Feng Yuan-Yuan , Du Hong , Huang Kai-Yuan , Ran Jin-Hua , Wang Xiao-Quan
Published: January 2024

The naturally occurring bisexual cone of gymnosperms has long been considered a possible intermediate stage in the origin of flowers, but the mechanisms governing bisexual cone formation remain largely elusive. Here, we employed transcriptomic and DNA methylomic analyses, together with hormone measurement, to investigate the molecular mechanisms underlying bisexual cone development in the conifer Picea crassifolia. Our study reveals a “bisexual” expression profile in bisexual cones, especially in expression patterns of B-class, C-class and LEAFY genes, supporting the out of male model. GGM7 could be essential for initiating bisexual cones. DNA methylation reconfiguration in bisexual cones affects the expression of key genes in cone development, including PcDAL12, PcDAL10, PcNEEDLY, and PcHDG5. Auxin likely plays an important role in the development of female structures of bisexual cones. This study unveils the potential mechanisms responsible for bisexual cone formation in conifers and may shed light on the evolution of bisexuality.
Neural and behavioral evidence for oxytocin’s facilitatory effects on learning in volatile and stable environments
Authors: Zhou Menghan , Zhu Siyu , Xu Ting , Wang Jiayuan , Zhuang Qian , Zhang Yuan , Becker Benjamin , Kendrick Keith M. , Yao Shuxia
Published: January 2024

Outcomes of past decisions profoundly shape our behavior. However, choice-outcome associations can become volatile and adaption to such changes is of importance. The present study combines pharmaco-electroencephalography with computational modeling to examine whether intranasal oxytocin can modulate reinforcement learning under a volatile vs. a stable association. Results show that oxytocin increases choice accuracy independent of learning context, which is paralleled by a larger N2pc and a smaller P300. Model-based analyses reveal that while oxytocin promotes learning by accelerating value update of outcomes in the volatile context, in the stable context it does so by improving choice consistency. These findings suggest that oxytocin’s facilitatory effects on learning may be exerted via improving early attentional selection and late neural processing efficiency, although at the computational level oxytocin’s actions are highly adaptive between learning contexts. Our findings provide proof of concept for oxytocin’s therapeutic potential in mental disorders with adaptive learning dysfunction.
NRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting
Authors: Sharma Swati , Ehrlich Marcelo , Zhang Manqi , Blobe Gerard C. , Henis Yoav I.
Published: January 2024

Endothelial cells express neuropilin 1 (NRP1), endoglin (ENG) and vascular endothelial growth factor receptor 2 (VEGFR2), which regulate VEGF-A-mediated vascular development and angiogenesis. However, the link between complex formation among these receptors with VEGF-A-induced signaling and biology is yet unclear. Here, we quantify surface receptor interactions by IgG-mediated immobilization of one receptor, and fluorescence recovery after photobleaching (FRAP) measurements of the mobility of another coexpressed receptor. We observe stable ENG/NRP1, ENG/VEGFR2, and NRP1/VEGFR2 complexes, which are enhanced by VEGF-A. ENG augments NRP1/VEGFR2 interactions, suggesting formation of tripartite complexes bridged by ENG. Effects on signaling are measured in murine embryonic endothelial cells expressing (MEEC+/+) or lacking (MEEC-/-) ENG, along with NRP1 and/or ENG overexpression or knockdown. We find that optimal VEGF-A-mediated phosphorylation of VEGFR2 and Erk1/2 requires ENG and NRP1. ENG or NRP1 increase VEGF-A-induced sprouting, becoming optimal in cells expressing all three receptors, and both processes are inhibited by a MEK1/2 inhibitor. We propose a model where the maximal potency of VEGF-A involves a tripartite complex where ENG bridges VEGFR2 and NRP1, providing an attractive therapeutic target for modulation of VEGF-A signaling and biological responses.
Realization of two-sublattice exchange physics in the triangular lattice compound Ba3Er(BO3)3
Authors: Ennis Matthew , Bag Rabindranath , Liu Chunxiao , Dissanayake Sachith E. , Kolesnikov Alexander I. , Balents Leon , Haravifard Sara
Published: January 2024

Geometric frustration commonly occurs in materials where magnetic rare-earth ions are arranged on a two-dimensional triangular lattice. These compounds have been gaining significant attention lately, as they hold the promise of revealing unique quantum states of matter. However, little attention has been devoted to cases where spin-$$\frac{1}{2}$$

1

2

rare-earth ions are substituted with ions exhibiting higher spin multiplicities. Here, we successfully synthesize high-quality single crystal samples of Ba3Er(BO3)3, which is part of the family of triangular lattice compounds. In our experiments, conducted at extremely low temperatures (around 100 millikelvin), we observe two sublattice exchange interactions in Ba3Er(BO3)3, resulting in the hexagonal lattice spins exhibiting a mixture of ferromagnetic and antiferromagnetic tendencies. Our theoretical analysis suggest that this behavior may be attributed to the distinct positions of magnetic ions within the crystal lattice. However, the presence of quantum effects adds an extra layer of complexity to our findings, calling for further exploration.
Glucose-derived glutamate drives neuronal terminal differentiation in vitro
Authors: D’Andrea Laura , Audano Matteo , Pedretti Silvia , Pelucchi Silvia , Stringhi Ramona , Imperato Gabriele , De Cesare Giulia , Cambria Clara , Laporte Marine H , Zamboni Nicola , Antonucci Flavia , Di Luca Monica , Mitro Nico , Marcello Elena
Published: January 2024

Neuronal maturation is the phase during which neurons acquire their final characteristics in terms of morphology, electrical activity, and metabolism. However, little is known about the metabolic pathways governing neuronal maturation. Here, we investigate the contribution of the main metabolic pathways, namely glucose, glutamine, and fatty acid oxidation, during the maturation of primary rat hippocampal neurons. Blunting glucose oxidation through the genetic and chemical inhibition of the mitochondrial pyruvate transporter reveals that this protein is critical for the production of glutamate, which is required for neuronal arborization, proper dendritic elongation, and spine formation. Glutamate supplementation in the early phase of differentiation restores morphological defects and synaptic function in mitochondrial pyruvate transporter-inhibited cells. Furthermore, the selective activation of metabotropic glutamate receptors restores the impairment of neuronal differentiation due to the reduced generation of glucose-derived glutamate and rescues synaptic local translation. Fatty acid oxidation does not impact neuronal maturation. Whereas glutamine metabolism is important for mitochondria, it is not for endogenous glutamate production. Our results provide insights into the role of glucose-derived glutamate as a key player in neuronal terminal differentiation.
High-entropy rare earth materials: synthesis, application and outlook
Authors: Fu Hao , Jiang Yong , Zhang Mengzhen , Zhong Ziyun , Liang Zhong , Wang Siyuan , Du Yaping , Yan Chunhua
Published: January 2024

A comprehensive review towards the synthesis, properties, application and outlook of high entropy rare earth materials including alloys and ceramics, as well as the distinctive issues related to their unique electronic structures.
Fluorescent and electrochemical detection of nuclease activity associated with Streptococcus pneumoniae using specific oligonucleotide probes
Authors: Goikoetxea Garazi , Akhtar Khadija-Tul Kubra , Prysiazhniuk Alona , Borsa Baris A. , Aldag Mehmet Ersoy , Kavruk Murat , Ozalp Veli C. , Hernandez Frank J.
Published: January 2024

A chemically modified oligonucleotide has been engineered to specifically target and interact with the nucleases associated with S. pneumoniae, enabling efficient detection of the bacteria through fluorescence and electrochemical biosensors.
Confidence limits in pulse dipolar EPR spectroscopy: estimates for individual measurements
Authors: Syryamina Victoria N. , Matveeva Anna G. , Bowman Michael K.
Published: January 2024

Effect of random noise in the dipolar trace biases the distance spectrum, and can not be evaluated from a single measurement.
Application of GaS nanotubes as efficient catalysts in photocatalytic hydrolysis: a first principles study
Authors: Zhao Huanyu , Zhu Yingtao , Wang Chao , Zhang Yujiao , Zhang Long
Published: January 2024

Visible light absorption indicates that GaS nanotubes can be effective photocatalysts for the production of H2 from water splitting.
Recycling of non-product outputs containing rare elements originating in nanomaterial syntheses
Authors: Reijnders Lucas
Published: January 2024

Recycling of non-product outputs containing substantial amounts of rare elements originating in nanomaterial syntheses is relatively attractive as rare elements tend to be more valuable than abundant elements.
Benzotrifuran-based donor–acceptor covalent organic frameworks for enhanced photocatalytic hydrogen generation
Authors: Yang Chuanmeng , Zhang Zhenwei , Li Jiali , Hou Yuxin , Zhang Qi , Li Zhongping , Yue Huijuan , Liu Xiaoming
Published: January 2024

A novel benzotrifuranyl COF with excellent photovoltaic properties and low exciton binding energy was successfully constructed and used for efficient photolysis of water.
Strengthening polylactic acid (PLA) composites with poly(methyl methacrylate)-functionalized cellulose nanofibrils created through grafting-through emulsion polymerization
Authors: Senkum Hathaithep , Kelly Peter V. , Ahmad Ahmad A. L. , Shams Es-haghi Siamak , Gramlich William M.
Published: January 2024

Aqueous surfactant free emulsion grafting-through polymerization produced poly(methyl methacrylate) coated cellulose nanofibrils that retained microstructure and strengthened poly(lactic acid) composites.
Optimization of safe doping level for enhanced CO2 flux in composite membrane
Authors: Jamale Atul P. , Henriques Gonçalo
Published: January 2024

Rare earth doped oxides have been intensively promoted for the last two decades to embrace the high-performance target of a ceramic–carbonate composite CO2-separation membrane, with countless incidents of exsolution.
A metabolomic snapshot through NMR revealed differences in phase transition during the induction of reproduction in Ulva ohnoi (Chlorophyta)
Authors: Bodar Payal A. , Thakur Rajendra Singh , Rajai Jasmine V. , Bhushan Satej , Mantri Vaibhav A.
Published: January 2024

The present study deals with the metabolomic status of Ulva cells undergoing phase transition (vegetative, determination and differentiation) when exposed to different abiotic conditions.
One-pot in situ construction of amido and hydroxyl co-modified layered double hydroxides for selective scandium adsorption
Authors: Huang Siyu , Yuan Cheng-Zong , Li Jiang , Zhang Lunliang , Zhao Hongrui , Zhao Wenkai , Zhang Xiaomeng
Published: January 2024

Amido and hydroxyl co-modified layered double hydroxides with high selective scandium adsorption performances were constructed via a one-pot in situ strategy.
Out-of-plane pressure and electron doping inducing phase and magnetic transitions in GeC/CrS2/GeC van der Waals heterostructure
Authors: Chen Kaiyun , Yan Xue , Deng Junkai , Bo Cunle , Song Mengshan , Kan Dongxiao , He Jiabei , Huo Wangtu , Liu Jefferson Zhe
Published: January 2024

The out-of-plane pressure and electron doping can induce phase and magnetic transitions in the GeC/CrS2/GeC van der Waals heterostructure, enabling local compression controlled lateral magnetic junctions. The electron doping significantly reduces the critical stress.
Photochemical synthesis, characterization, and electrochemical sensing properties of CD–AuNP nanohybrids
Authors: Nocito Giuseppe , Zribi Rayhane , Chelly Meryam , Pulvirenti Luca , Nicotra Giuseppe , Bongiorno Corrado , Arrigo Antonino , Fazio Barbara , Neri Giovanni , Nastasi Francesco , Conoci Sabrina
Published: January 2024

Carbon dots (CDs) have been prepared from olive solid wastes and employed as capping agents in photo-activated gold-nanoparticles synthesis, thus creating CD–Au nanohybrids which act as an efficient material for electrochemical sensing hydroquinone.
Synthesis of 4-(trichloromethyl)pyrido[2′,1′:3,4]pyrazino[2,1-b]quinazolinones through a cyclized dearomatization and trichloromethylation cascade strategy
Authors: Zhang Xu , Wei Meng-Yan , Su Jun-Cheng , Liang Cui , Pan Cheng-Xue , Su Gui-Fa , Mo Dong-Liang
Published: January 2024

An intramolecular 6-endo-dig cyclization and trichloromethylation of N3-alkynyl-2-pyridinyl-tethered quinazolinones in chloroform was developed for the synthesis of various 4-trichloromethylated pyrido-fused quinazolinones in moderate to good yields with high regioselectivity.
PEO/Li1.25Al0.25Zr1.75(PO4)3 composite solid electrolytes for high-rate and ultra-stable all-solid-state lithium metal batteries with impregnated cathode modification
Authors: Zhang Yongquan , Gao Hongchang , Wang Jingshun , Chi Qingguo , Zhang Tiandong , Zhang Changhai , Feng Yu , Zhang Yue , Cao Dianxue , Zhu Kai
Published: January 2024

All-solid-state lithium metal batteries (ASSLMBs) are considered the most competitive next-generation energy storage batteries due to their high energy density and high safety.
Achieving ultrasensitive temperature sensing through non-thermally coupled energy levels to overcome energy gap constraints
Authors: Xiang Guotao , Yi Yuanyuan , Yang Zhiyu , Wang Yongjie , Yao Lu , Jiang Sha , Zhou Xianju , Li Li , Wang Xiaojun , Zhang Jiahua
Published: January 2024

Ultrasensitive temperature sensing is realized through non-thermally coupled energy levels to overcome energy gap constraints.
Covalent organic frameworks with interlayer fixed Pt atoms for efficient electrocatalytic hydrogen evolution
Authors: Fan Daqing , Wang Weiwen , Ma Tian , Luo Xianglin , He Chao , Liu Xikui , Li Shuang
Published: January 2024

TTB-COF with different crystallinities loaded with Pt atoms were synthesized for HER. The Pt@TTB-COF with higher crystallinity exhibited excellent performance with low overpotential of 5 mV at 10 mA cm−2 and high TOF value of 5.43 H2 S−1 at 50 mV.
Molecular modulation strategies for two-dimensional transition metal dichalcogenide-based high-performance electrodes for metal-ion batteries
Authors: Gu Mingyuan , Rao Apparao M. , Zhou Jiang , Lu Bingan
Published: January 2024

Through the purposeful modulation of specific parts or regions of TMD molecules, molecular modulation strategies aim to realize the effective modulation of TMDs' properties from an ‘internal’ perspective.
A cysteine-specific solubilizing tag strategy enables efficient chemical protein synthesis of difficult targets
Authors: Li Wenchao , Jacobsen Michael T. , Park Claire , Jung Jae Un , Lin Nai-Pin , Huang Po-Ssu , Lal Rayhan A. , Chou Danny Hung-Chieh
Published: January 2024

We developed a new cysteine-specific solubilizing tag strategy via a cysteine-conjugated succinimide.
MXene quantum dots for ratiometric fluorescence detection of a Bacillus anthracis biomarker
Authors: Lin Chunxiao , Qiu Chubei , Wang Yanan , Liu Yaowen , Rong Mingcong , Niu Li
Published: January 2024

Fluorescent MQDs were synthesized through a hydrothermal process, and a corresponding test paper was developed for the visual detection of an anthrax biomarker.
Photo-responsive hydrogels based on a ruthenium complex: synthesis and degradation
Authors: Tavakkoli Fard Sara , Thongrom Boonya , Achazi Katharina , Ma Guoxin , Haag Rainer , Tzschucke C. Christoph
Published: January 2024

We report the synthesis of a photo responsive metallo-hydrogel based on a ruthenium(ii) complex as a functional cross-linker.
An antibacterial hydrogel prepared from a licorice residue extract
Authors: Shi Xiaoru , Wang Liqun , Chen Qian , Zheng Qijian , Chen Hongli , Li Xi
Published: January 2024

A licorice residue extract was used as a precursor to prepare hydrogels in this study.
Dual role of hBN as an artificial solid–electrolyte interface layer for safe zinc metal anodes
Authors: Wong Hoilun , Tang Tsz Wing , Chen Haoliang , Xu Mengyang , Wang Jun , Cai Yuting , Goddard William A. , Luo Zhengtang
Published: January 2024

Monolayer and large area hBN as an artificial SEI layer shows dual role in preventing the undesired side reaction of HER and inducing the heteroepitaxial grown of Zn, successfully resolving the dendrite issue for safe Zn metal anode.
A data-mining approach to understanding the impact of multi-doping on the ionic transport mechanism of solid electrolytes materials: the case of dual-doped Ga0.15/Scy Li7La3Zr2O12
Authors: Cortés Henry A. , Bonilla Mauricio R. , Früchtl Herbert , van Mourik Tanja , Carrasco Javier , Akhmatskaya Elena
Published: January 2024

Uncovering Ga/Sc dual-doping effects on Li-ion dynamics in LLZO through molecular dynamics, Monte Carlo simulations, and data mining clustering techniques.
Structural electrochemistry of poly(3,4-ethylenedioxythiophene) and its applicability as simultaneous sensor of environmental surroundings: self-sensing electrical, thermal, and chemical working conditions
Authors: Rajan Lijin , Sidheekha Madari Palliyalil , Shabeeba Aranhikundan , Otero Toribio F. , Ismail Yahya A.
Published: January 2024

An extensive electrochemical investigation of PEDOT has been carried out with a particular focus on understanding the structural electrochemistry during its faradaic process, a topic that has not been previously explored in such detail.
Large transverse magneto-thermoelectric effect in narrow-band-gap polycrystalline Ag2−δTe
Authors: Chen Mingyu , Feng Tao , Yin Nan , Shi Quan , Jiang Peng , Bao Xinhe
Published: January 2024

Polycrystalline Ag2−δTe is promising for transverse energy conversion applications due to its high transverse thermoelectric performance.
β-Glycosidase sensitive oral nanoparticles for combined photothermal and chemo treatment of colorectal cancer
Authors: Zhou Jingning , Zhuang Zequn , Gao Rui , Li Ran , Chen Yigang
Published: January 2024

Colorectal cancer is one of the most common malignant tumors in the world, and its treatment strategies mainly include surgical resection, chemotherapy, adjuvant radiotherapy, and immunotherapy.
Enzymatic micro/nanomotors in biomedicine: from single motors to swarms
Authors: Chen Shuqin , Prado-Morales Carles , Sánchez-deAlcázar Daniel , Sánchez Samuel
Published: January 2024

Micro/nanomotor swarms propelled by diverse mechanisms.
Correction: An E-selectin targeting and MMP-2-responsive dextran–curcumin polymeric prodrug for targeted therapy of acute kidney injury
Authors: Hu Jing-Bo , Liu Di , Qi Jing , Lu Kong-jun , Jin Fei-yang , Ying Xiao-Ying , You Jian , Du Yong-Zhong
Published: January 2024

Correction for ‘An E-selectin targeting and MMP-2-responsive dextran–curcumin polymeric prodrug for targeted therapy of acute kidney injury’ by Jing-Bo Hu et al., Biomater. Sci., 2018, 6, 3397–3409, https://doi.org/10.1039/C8BM00813B.
Pseudorange reconstruction for high‐dynamic eLoran signal simulators using B‐spline interpolation
Authors: Ma Hongyu , Zhao Yuchen , Du Yongxing , Du Zhonghong , Xi Xiaoli
Published: January 2024

The High‐Dynamic enhanced Loran (eLoran) signal simulator must accurately model the motion parameters and dynamic transmission delays of the carriers in the channel. A method was proposed based on B‐Spline interpolation, capable of arbitrary ratio interpolation and multi‐channel simulation. This method can regenerate carrier‐to‐transmitter distances from available discrete motion asynchronous data, it can effectively reproduce more motion details for carrier. The algorithm can be implemented using digital circuits, allowing for real‐time simulation on a hardware platform. The circuit structure is divided into integer and fractional calculations, which can satisfy the interpolation of asynchronous data with arbitrary ratios. Compared with existing methods, the approach simulates the motion parameters with satisfactory accuracy.
Temperature control of atomic gas chamber using a nonmagnetic heating chip fabricated on quartz substrate
Authors: Shi Ming , Zhang Weimin , Wang Ling , Zhang Fan , Hou Jin , Yang Chunyong
Published: January 2024

Nonmagnetic electrical heating and temperature sensing chip fabricated on quartz substrate is developed, and a high-precision digital temperature control system is designed based on this chip. The heating resistance and temperature sensing resistance are prepared by depositing two layers of Ti/Pt alloy electrodes on quartz substrate through magnetic field cancellation design. The temperature coefficient of fabricated Ti/Pt temperature sensing resistance is +0.197%/℃. The simulation results show that the residual magnetic field generated by the heating current in the atomic gas chamber closely adjacent to the chip is less than 0.1 nT. Temperature control in the range of 100~150 ℃ is realized, and the temperature stability is about 0.02 ℃. Due to the high light transmittance of quartz glass, this heating chip has significant advantages for optical integration and miniaturization of atomic magnetometers.
Franchir les frontières. Pratiques de l’interdisciplinarité et construction du chercheur
Authors: Riaux Jeanne , Carrière Stéphanie M. , Chotte Jean-Luc , Fournet Florence
Published: January 2024

Ce texte contribue à un large ensemble de réflexions sur l’interdisciplinarité. Au travers des trajectoires personnelles des coauteurs, il vise à comprendre le rôle de l’interdisciplinarité « de l’intérieur », dans la construction des chercheuses et des chercheurs et, partant, de porter un regard positif sur cette pratique souvent présentée sous un angle négatif (difficultés, écueils, etc.). Les exemples concrets de franchissements des frontières disciplinaires, sont autant de témoignages de la diversité des trajectoires. Mais à travers cette diversité se dessinent des traits communs. L’interdisciplinarité s’est construite en même temps que l’identité scientifique de chacun s’est façonnée. Cette construction particulière n’est probablement pas sans lien avec une certaine proximité avec le « terrain », dans toutes ses composantes physiques ou sociales. Elle est aussi le propre d’une hybridation entre les parcours individuels et la diversité des expertises scientifiques et culturelles des collègues avec lesquels se nouent les collaborations. Ce retour d’expérience réflexif offre à l’analyse de la pratique interdisciplinaire quelques éléments d’objectivation, notamment sur la manière dont elle façonne les trajectoires individuelles et sur le rôle du décentrement et de la réflexivité dans ces trajectoires.
La famille dans tous ses éclats
Authors: Gassmann Xavier
Published: January 2024

La famille convoque en chacun des représentations idéalisées et nostalgiques. Travailler auprès des familles, en particulier dans le champ de la protection de l’enfance met nécessairement à l’épreuve ces représentations et interroge ce qui structure la famille. La garantie de la place de chacun dans la famille n’est pas toujours assurée au point de se trouver confronter à une désorganisation implicite mise en évidence par la violence donnée à voir. Derrière le règne de la confusion et de l’éclat, comment se dialectise l’accès aux interdits fondamentaux ?
Short-term functional outcomes of robotic-assisted TKA are better with functional alignment compared to adjusted mechanical alignment
Authors: Jeffrey Michaud , Marchand Philippe , Kouyoumdjian Pascal , Coulomb Remy
Published: January 2024

Introduction: Ligament balancing is essential to the functional outcome of total knee arthroplasty (TKA). The optimal method of alignment remains a controversial issue. The primary objective was to compare the clinical outcomes of TKA between functional and adjusted mechanical alignment techniques. The secondary objectives were to compare bone resection, robotic alignment, and radiological assessment. Materials and methods: This was a retrospective case-control series comparing TKA performed with functional alignment (FA) and adjusted mechanical alignment (aMA). Sixty-four FA subjects were matched with 64 aMA controls. These two groups were matched for age, gender, body mass index (BMI), surgeon, and type of frontal deformity. Both surgical procedures were performed using the MAKO® haptic robotic system. Functional scores (Forgotten Joint Score (FJS), Knee Society Score (KSS), and Oxford Knee Score (OKS)) were measured at the final postoperative follow-up. A radiographic evaluation was performed at the same time. Results: Mean FJS were respectively 63.4 ± 25.1 [0–100] and 51.2 ± 31.8 [0–100] in FA versus aMA group (p = 0.034). Mean OKS were respectively 40.8 ± 6.3 [21–48] and 34.9 ± 11.8 [3–48] in FA versus aMA group (p = 0.027). Mean KSS were respectively 184.9 ± 17.0 [126–200] and 175.6 ± 23.1 [102–200] in FA versus aMA group (p = 0.02). The main residual symptom was “none” for 73.0% versus 57.8%, “instability” for 6.4% versus 21.9%, “Pain” for 19.1% versus 12.5%, and “effusion” for 1.6% and 7.8% respectively for FA and aMA group (p = 0.016). There were 4 complications in the FA group versus 5 in the aMA group (p > 0.999). Mean postoperative hip-knee-ankle (HKA) robotic assessment were respectively 177.3° ± 2.0 [172–180] and 178.2° ± 2.0 [173–180] for FA and aMA group (p = 0.018). The median difference between HKA robotic and HKA radiological was −3.0° (IQR = 3.0; p < 0.001). Conclusion: With greater residual deformity and without release, functional alignment showed a statistically significantly better short-term clinical outcome than adjusted mechanical alignment. This difference may not be clinically significant.
Endothelzellverlust bei phaken Intraokularlinsen
Authors: Naujokaitis Tadas , Auffarth Gerd U. , Łabuz Grzegorz , Khoramnia Ramin
Published: January 2024

Obwohl die Sicherheit der phaken Intraokularlinsen (pIOLs) über eine bereits 70-jährige Entwicklungsgeschichte kontinuierlich verbessert wurde, können hohe Endothelzellverluste auch bei den aktuellen pIOL-Modellen auftreten. Die Studienergebnisse zeigen, dass die Entfernung einer pIOL zum Hornhautendothel eine entscheidende Rolle beim Endothelzellverlust spielt. Allein deswegen werden bei den Vorderkammerlinsen tendenziell höhere Endothelzellverluste beobachtet als bei den Hinterkammerlinsen. Eine ausreichende präoperative Vorderkammertiefe ist essenziell, zumindest bei den irisfixierten pIOLs, um eine sichere Distanz zum Endothel zu gewährleisten. Die Vorderkammer wird jedoch mit zunehmendem Alter flacher und es kann deswegen sinnvoll sein, das Patientenalter bei den Sicherheitskriterien mitzuberücksichtigen. Obwohl der Endothelzellverlust bei den aktuellen pIOL-Modellen i. d. R. gering ist, sind regelmäßige Kontrollen mit Messung der Endothelzelldichte aufgrund großer
interindividueller Unterschiede bei den Patienten mit pIOLs nach wie vor unverzichtbar. Falls ein höherer Endothelzellverlust beobachtet wird als erwartet und die nachfolgenden Kontrollen die Tendenz bestätigen, soll die pIOL rechtzeitig explantiert werden. Hierbei ist die Endothelreserve individuell zu betrachten, indem man das Patientenalter, den physiologischen Endothelzellverlust sowie den Verlust durch weitere Operationen berücksichtigen sollte. Bei einer sorgfältigen Indikationsstellung und einer langfristigen Patientenbetreuung stellen die pIOLs nach wie vor eine sichere Behandlungsoption dar.
Does Accidental Hypothermia Increase Morbidity and Mortality in
Mature Neonates?
Authors: Petersen Lisa , Kainer Franz , Schroth Michael Andreas
Published: January 2024

Accidental hypothermia in mature neonates requiring hospitalization is a clinical
complication that has not been studied in detail. In the present study, the
effect of accidental hypothermia on common morbidity in neonates in the
postnatal period was investigated. We did temperature measurements in 616 mature
neonates after birth, after transfer to the maternity ward and at check-up at
age of 48–72 hours of life. Additionally, nurses checked
temperature until discharge at every diaper change in 302 of all included
neonates who were small for gestational age (SGA) or whose mothers had green
fluid or premature rupture of membranes (PROM). We investigated if there was a
correlation between infection, hyperbilirubinemia, hypoglycemia, SGA,
gestational diabetes, PROM, green amniotic fluid, positive GBS status of the
mother, and accidental hypothermia in the first 48–72 hours of
life. Mature neonates showed transient accidental hypothermia in the first
24 hours of life. No significant correlation between infection
(p=0.571), hyperbilirubinemia (p=0.837), hypoglycemia
(p=0.072), and accidental hypothermia could be seen. There was a
significant correlation between SGA (p=0.020), PROM (p=0.008),
and accidental hypothermia, while hyperthermia was associated with infection
(p=0.009) and green amniotic fluid (p=0.004). SGA and PROM
represent perinatal risk factors for postnatal transient accidental hypothermia
in mature neonates. Increased morbidity or mortality associated with postnatal
accidental hypothermia has not been demonstrated.
Characteristics of Ovarian Cancer Immune Cell Invasion and
Bioinformatics to Predict the Effect of Immunotherapy
Authors: Yan Lingli , Fan Erxi , Tan Bin
Published: January 2024

Recent studies have confirmed that tumor immune cell infiltration (ICI) is
associated with sensitivity of ovarian cancer (OC) immunotherapy and disease
progression of OC patients. However, studies related to immune infiltration in
OC, has not been elucidated. Two algorithms are used to analyze the OC data in
the TCGA and GEO databases. After combining the two data sets, the immune cell
content of the sample was estimated by Cell-type Identification By Estimate
Relative Subsets of RNA Transcripts (CIBERSORT method). An unsupervised
consistent clustering algorithm was used to analyze ICI subtypes and their
differentially expressed genes (DEGs). Two subgroups and three ICI gene clusters
were identified by unsupervised consensus clustering algorithm. The ICI score
was obtained by analyzing the gene characteristics through principal component
analysis (PCA). The ICI score ranged from –15.8132 to 18.7211, which was
associated with the prognosis of OC patients with immunotherapy. The Toll-like
receptor pathway, B-cell receptor pathway, antigen processing and presentation
pathway, NK-cell-mediated cytotoxicity pathway, and arginine-proline metabolism
pathway were activated in the high ICI score group, suggesting that immune cells
in the high ICI score group were activated, thus leading to a better prognosis
in this group of patients. Patients with G3–G4 in the high ICI rating
group were more sensitive to immunotherapy and had a better prognosis in
patients with high tumor mutation burden (TMB). This study suggests that ICI
scores can be used as a feasible auxiliary indicator for predicting the
prognosis of patients with OC.
Electrode Montage for Bilateral Cervical Vestibular-Evoked Myogenic Potential Testing
Authors: Patterson Jessie N. , El Hidek Nour , Janky Kristen L.
Published: January 2024

Background Cervical vestibular-evoked myogenic potentials (cVEMPs) are predominantly ipsilateral, myogenic responses originating from saccular activation. Some individuals have contralateral-crossed cVEMP responses with monaural air-conducted stimulation (ACS) which can contaminate cVEMP responses with bilateral stimulation. While the origin of the contralateral-crossed response is under debate, its presence has implications for cVEMP testing with midline bone conduction vibration (BCV).

Purpose The purpose of this study was to determine the origin of the contralateral-crossed cVEMP response. It was hypothesized that the crossed response is due to electrode contamination and would disappear with a modified electrode montage.

Research Design This is a cross-sectional research study.

Study Sample Fifteen healthy participants (30 ears; mean age: 27.4 19–39; 10 females).

Data Collection and Analysis Participants completed cVEMP testing using three stimulation methods (monoaural ACS, binaural ACS, and midline BCV) and two electrode montages (sternum reference and Fp reference).

Results In the monoaural ACS with sternum reference condition, 53.3% ears had contralateral-crossed cVEMP responses that were in-phase with the ipsilateral response for all but three ears. Whereas in the monoaural ACS with Fp reference condition, 3% had a contralateral-crossed cVEMP response. ACS and BCV cVEMP corrected amplitudes were significantly larger in the sternum reference conditions, which is attributed to artificial enhancement from the in-phase contralateral-crossed responses.

Conclusions The significant reduction of contralateral-crossed responses in the Fp reference condition suggests that the contralateral-crossed cVEMP response is due to reference electrode contamination and may be a more appropriate reference placement when completing cVEMPs with midline BCV.
A Historical Review of Racial, Ethnic, and Gender Diversity in Plastic Surgery at the University of Michigan
Authors: Levy Julien J.S. , Hooper Rachel C.
Published: January 2024

In this article, we examine the 60-year history of diversity efforts within the Section of Plastic Surgery at the University of Michigan (UofM) in the context of national trends. We describe the experiences of pioneering Underrepresented in Medicine (URiM) and female graduates of the program. James Norris, MD, and Christine Sullivan, MD, were the first URiM and female graduates from UofM in 1974 and 1989, respectively. Currently, women constitute over one-half the plastic surgery trainees at UofM, but URiM trainee representation remains limited. Dr. Adeyiza Momoh and Dr. Amy Alderman were the first URiM and female faculty members hired in 2011 and 2004, respectively. At present, there are four URiM and seven female faculty members in the Section. With a shared vision, supportive leadership, and motivation to change, faculty diversity has increased substantially. Additional strategies, including ongoing pipeline programs in medicine and science for URiM and women, are needed to further increase workforce diversity in plastic surgery.
Time to Revision Total Hip Arthroplasty Impacts Short-Term Outcomes Following Surgery
Authors: Lorentz Nathan A. , Roof Mackenzie A. , Christensen Thomas , Yeroushalmi David , Aggarwal Vinay K. , Meftah Morteza , Schwarzkopf Ran
Published: January 2024

Previous reports have investigated the correlation between time to revision total hip arthroplasty (rTHA) and reason for revision, but little is known regarding the impact of timing on outcomes following rTHA. The purpose of this study is to evaluate the effect of time to rTHA on outcomes following rTHA. This retrospective observational study reviewed patients who underwent unilateral, aseptic rTHA at an academic orthopaedic hospital between June 2011 and April 2020 with at least 1-year of follow-up. Patients were categorized as early revisions if revised within 2 years of primary total hip arthroplasty (pTHA) or late revisions if revised after more than 2 years from pTHA. Patient demographics, surgical factors, and postoperative outcomes were compared. Multiple linear regression and binary logistic regression were used to determine significance of outcomes while controlling for confounding variables. Of the 467 cases, 150 underwent early revision and 317 underwent late revision. Early revisions experienced longer hospital length of stays (LOSs, days; 4.93 ± 3.93 vs. 3.28 ± 2.09; p < 0.001), all-cause 90-day readmission rates (11.3 vs. 12.7%; p = 0.032). Across all revision types, multivariate analysis revealed that time to rTHA (p < 0.001) and revision type (0.008) were found to be significant predictors of LOS while controlling for patient factors. Subanalyses within each revision type (femoral, acetabular, head/liner, and full) further reveal that time to rTHA is a significant independent predictor of LOS. Early revisions had a greater proportion of femoral revisions (44.0 vs. 15.5%), and late revisions had a greater proportion of head/liner (43.2 vs. 18.7%; p < 0.001) revisions. There were no significant differences between the two cohorts with respect to discharge disposition, surgical time, all-cause 90-day emergency department (ED) visits, re-revisions, and number of re-revisions. Patients undergoing aseptic rTHA within 2 years of index pTHA had longer LOS and greater rates of readmission. Time to rTHA is a significant independent predictor of LOS across and within all revision types and reason for revision aside from liner exchange and trunnionosis. No differences were seen in operative time, discharge disposition, re-revision, mortality, reoperation, and ED admission between early and late rTHAs across all revision subtypes. Level of evidence is III, retrospective observational analysis.
Retraction Note: Relationship Between Multiple Sclerosis and Spiritual Distress
Authors: Çaksen Hüseyin
Published: January 2024

Retraction

An investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Epilepsy in Volume 12, Number 03, 89-90, in September 2023 (DOI: 10.1055/s-0043-1764149), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: Treatment Failure in Children with Cancer
Authors: Çaksen Hüseyin
Published: January 2024

Retraction

An investigation by the publisher found a number of articles, including this one, published in Journal of Child Science in Volume 12, Number 01, e106–e107, on September 29, 2022 (DOI: 10.1055/s-0042-1756720), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: Use of Prayer by Parents in Pediatric Emergency Department Patients
Authors: Çaksen Hüseyin
Published: January 2024

Retraction

An investigation by the publisher found a number of articles, including this one, published in Journal of Child Science in Volume 12, Number 01, e90–e91, on September 19, 2022 (DOI: 10.1055/s-0042-1757141), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: Salvation of the Prophet Yunus (Alayhi As-Salam), Swallowed by the Big Fish: A Message for Today's Physicians
Authors: Çaksen Hüseyin
Published: January 2024

Retraction

An investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on January 03, 2023 (DOI: 10.1055/s-0042-1760195), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: Use of Ruqyah in Patients with Neuropsychiatric Disorders
Authors: Çaksen Hüseyin
Published: January 2024

Retraction

An investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on October 11, 2022 (DOI: 10.1055/s-0042-1757622), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
The relationship of real-life interpersonal difficulties and Chinese adolescents’ online deviant behavior: a U-shaped mediated moderating effect of online morality
Authors: Chen Yanlei , Guo Shaoyang , Yu Yuanyuan
Published: January 2024

Based on the integrated perspective of reality and virtual networks, this study aims to explore the mechanism of how interpersonal difficulties influence Chinese adolescents’ online deviant behavior and the roles of online morality and online social support in this relationship. A questionnaire containing four psychological scales was administered to 1,120 Chinese adolescents, and the meditating and moderating effects were analyzed using structure equation modeling. The results show that (1) Real-life interpersonal difficulties and online social support can significantly increase online deviant behavior, whereas online morality can significantly decrease such behavior. (2) There is a U-shaped mediated moderating effect: The recovering effect of morality for the impact of interpersonal difficulties on online deviant behavior is only effective for individuals with high moral levels and mild interpersonal difficulties; however, once interpersonal difficulties exceed the critical threshold, online deviant behavior will surge, particularly among individuals with high online morality. (3) There is a moderated mediating effect: Online social support is a mediator between interpersonal difficulties and online deviant behavior, and online morality can negatively moderate the impact of online social support on online deviant behavior. Furthermore, this study also proposed a theoretical model to explain how online deviant behavior happens, which can be used to control and reduce online deviant behavior.