bluuebunny/crossref_metadata_2025 huggingface dataset:
A Longitudinal Document-based Analysis of the Turkish Reading Curricula Regarding Embedded Intellectual Demands
Authors: Kaldirim Abdullah , Tavsanli Omer Faruk
Published: November 2024

The purpose of this longitudinal study was to critically evaluate the updated Turkish reading curricula to determine whether they enable teachers to design instructional sequences that are highly cognitively demanding. This study was designed as a qualitative inquiry using document analysis to estimate the pedagogically oriented intellectual demands of the reading field’s curricular objectives. A total of 1,542 reading objectives were thoroughly examined and the generic picture of the longitudinal analysis shows that the objectives at the understand level dramatically dominate (49.3%) the reading instruction at the elementary and middle school levels. Approximately one-third of the objectives in the curricula were categorized at the remember level, indicating that the intellectual demands of the reading curricula predominantly focus on lower-order cognitive skills from elementary to middle school. None of the 1,542 reading objectives were classified at the create (0%) level. Only 9.26% of all objectives could potentially be utilized to design educational sequence requiring higher cognitive processing, such as at the analyze level. Similarly, only 3.04% of all objectives could be translated into instructional episodes that necessitate cognitive processes at the evaluate level by teachers. Educational recommendations are offered to teachers, curriculum developers, and educational policymakers.
The Impact of Domestic Companies’ CSR Targets on Consumer Post-Purchase Responses: The Moderating Effects of Brand Reputation
Authors: Park Kikyoung
Published: November 2024

With the growing interest in the environment, society, and governance, responsible management emphasizes corporate social responsibility (CSR) activities. Drawing upon social identity theory, this study explores the interplay between a brand’s CSR target (domestic or abroad) and its reputation in shaping consumers’ post-purchase product attitudes. Through two complementary experiments, the findings reveal that consumers exhibit more favorable post-purchase attitudes toward domestic brands with a high reputation when their CSR activities are targeted domestically. Conversely, the target of CSR activities does not significantly impact post-purchase product attitudes toward domestic brands of lower reputation. Further analysis reveals that for high-reputation brands, the perceived fairness of CSR activities is crucial, whereas, for lower reputable brands, the role of CSR activities is essential in reducing product risk, making the target country of CSR irrelevant. This study indicates that CSR strategies should be customized according to brand reputation, with significant implications for enhancing sustainable consumer brand loyalty.
Effect of composite resins with and without fiber-reinforcement on the fracture resistance of teeth with non-carious cervical lesions
Authors: Hazar Ahmet , Hazar Ecehan
Published: November 2024

Objective:

Non-carious cervical lesions (NCCLs) are commonly observed in clinical dentistry, leading to tooth fractures, sensitivity, and compromised pulp vitality. Therefore, their restoration is essential for both the aesthetic and structural integrity of teeth. This study aimed to compare the fracture resistance of NCCLs restored using different materials: an injectable universal composite, flowable bulk-fill composites with or without fiber-reinforcement.

Methods:

Seventy-five double-rooted maxillary premolars were selected for the study. Fifteen teeth were left intact as a control. A wedge-shaped cavity was prepared in the cervical region of the remaining sixty teeth, which were then divided into four groups ( n = 15): unrestored, restored with an injectable composite, restored with a flowable bulk-fill composite (SDR® flow+), and restored with a flowable short-fiber-reinforced composite (everX Flow™). All teeth underwent fracture testing under oblique static loading at a 30° angle using a universal testing machine. Fracture patterns were classified as repairable, possibly repairable, or unrepairable. Data were analyzed using one-way analysis of variance, Pearson chi-square, and Tukey HSD post hoc tests ( p = 0.05).

Results:

Intact teeth exhibited the highest fracture resistance (743.481 N), while unrestored teeth showed the lowest (371.49 N) ( p < 0.001). There was no significant difference in fracture resistance between the injectable composite (553.289 N) and SDR® flow+ (497.368 N) ( p = 0.055). The everX Flow™ group displayed significantly higher fracture resistance (673.787 N) ( p < 0.001) and a repairability rate of 60% within the restored groups. Unrestored (60%), injectable composite (53.3%), and SDR® flow+ (53.3%) groups were mostly unrepairable.

Conclusion:

The everX Flow™ demonstrated improved fracture resistance and favorable fracture pattern for maxillary premolars with wedge-shaped NCCLs.
Exploring the Factors Influencing People to Follow a Social Media Influencer
Authors: Haldar Piali
Published: November 2024

Social media influencers also identified as micro-celebrities commonly entitled influencers, who provide content or thoughts based on their ideas and present experiences and ideas in the form of content or opinions. They are gaining popularity in the world of brand endorsement for attracting, developing and retaining consumers for their financial gain. The key emphasis of this study is to comprehend what motivates an individual to follow an influencer on social media platforms, so that the companies can efficaciously choose a social media influencer for their brand endorsement. Specifically, the major purpose of this study was to explore why an individual follows an influencer, so company can choose an influencer effectively. To achieve these aims, we choose to use questionnaires for an online survey among the social media users who follow at least one influencer, the questionnaire was circulated through social media and email. 392 individuals above 16 years old filled out the questionnaire. The outcome of the study confirmed that there are seven primary factors that motivate the social media audience to follow their selected influencers, namely authenticity, trustworthiness, attractiveness, credibility, expertise, legitimacy and likeability. The key takeaway from the study is that marketers, influencers and advertising agencies will be able to understand what factors affect the social media audience’s intention to follow the influencers. This study will make theoretical as well as practical contributions for the marketers as well as the influencers to understand what influences the users’ intention to follow social media influencers.
An Inclusive Education Teacher-Training Program in a Peripheral City in Israel
Authors: Menzin Daniela , Bar Nir Aviva , Kimhi Yael
Published: November 2024

Inclusive education offers accessibility to school settings for all children, regardless of background or disability. This retrospective mixed-methods study examined the attitudes of teacher candidates regarding inclusive education, after participating in a unique year-long program on this topic. The study included 42 teacher candidates and 38 mentor teachers from two elementary schools in southern Israel. The study also examined whether candidates would recommend the program, and the program’s impact regarding the teacher candidates and their mentors’ sense of self-efficacy. The findings show that 71% of candidates reported that the main advantage of the program was instilling values of acceptance and tolerance; 71% also stated that its main disadvantage was excessive workload. When examining recommendations for future implementation, 60% of the variance was predicted by “The inclusive education program has enhanced my ability to effectively manage a classroom in the future.” Finally, the mentors’ sense of self-efficacy was significantly higher than the candidates.
Effectiveness of sorafenib in treating intermediate-stage hepatocellular carcinoma patients refractory to transarterial chemoembolization
Authors: Ashour Reham , Rewisha Eman , Rady Mohamed AKL , Elkhadry Sally Waheed , Abdelhalim Heba , Atef Mohamed
Published: November 2024

Background

Switching to systemic therapy after transarterial chemoembolization (TACE) refractoriness is more inclined to preserve liver function and decrease disease progression. Hence, we conducted a comparison between the advantages of sorafenib therapy and the continuation of TACE in patients with intermediate-stage hepatocellular carcinoma (HCC) who developed TACE refractoriness.

Methods

This retrospective cohort work involved 1,200 patients with HCC who received TACE therapy at our institution between January 2018 and December 2022. Out of these, a total of 436 participants were determined to be resistant to TACE treatment throughout their clinical progression. Out of them, 271 were finally included and categorized into two groups: (1) patients who shifted from TACE to sorafenib, and (2) patients who maintained TACE treatment. The study assessed the overall survival (OS) and time to disease progression (TTDP) of patients who were resistant to TACE, comparing both groups based on when they achieved Child-Pugh C or acquired advanced-stage HCC.

Results

Following confirmation of refractoriness to TACE therapy, 163 opted to continue with TACE (TACE group), whereas 108 shifted to sorafenib treatment (sorafenib group). The median TTDP was 23.36 months, while the median OS was 25.3 months, in the sorafenib group, and 11.6 and 14.2 months, correspondingly, in the TACE group (p = 0.0001).

Conclusion

Switching to sorafenib treatment significantly improved OS and TTDP in patients with intermediate-stage HCC who were refractory to TACE. These finding highlights sorafenib’s potential as an effective alternative for managing disease progression in patients unresponsive to TACE, offering a valuable treatment option in this challenging clinical scenario.
The IMPACT Survey: the humanistic impact of osteogenesis imperfecta in adults
Authors: van Welzenis Taco , Westerheim Ingunn , Hart Tracy , Wekre Lena Lande , Semler Oliver , Rauch Frank , Dewavrin Laetitia , Dadzie Ruby , Prince Samantha , Raggio Cathleen
Published: November 2024

Background

The IMPACT Survey explored the humanistic, clinical, and economic burden of osteogenesis imperfecta (OI) on individuals with OI, their families, caregivers, and wider society. Two previous publications report research methodology, initial insights of the survey, and cost of illness of OI. Here, we present data on the impact of OI on the quality of life (QoL) of adults with OI and explore potential drivers of this impact.

Methods

The IMPACT Survey was an international mixed methods online survey in eight languages (fielded July–September 2021), aimed at adults (aged ≥ 18 years) or adolescents (aged 12–17 years) with OI, caregivers (with or without OI) of individuals with OI, and other close relatives. Survey domains included demographics, socioeconomic factors, clinical characteristics, treatment patterns, QoL, and health economics. We conducted a descriptive analysis of the QoL data, as well as exploratory regression analyses to identify drivers of impact of OI on QoL (independent associations between patient characteristics and the impact on QoL).

Results

1,440 adults with OI participated in the survey. The proportion who reported an impact of OI on their QoL across individual areas in the physical, socioeconomic, and mental well-being domains ranged between 49 and 84%. For instance, 84% of adults reported an impact of OI on the types of leisure activities they could do and 74% on the type of job they could do. More severe self-reported OI and higher fracture frequency were consistently identified as drivers of OI’s impact on QoL. The proportion of adults who reported worrying about different aspects of their lives due to their OI, such as mobility loss, future fractures, and ageing, ranged between 31 and 97%.

Conclusion

IMPACT provides insights into the humanistic burden of OI on adults, revealing that OI has a substantial impact on the QoL of adults. OI severity and fracture frequency were consistently identified as drivers of impact on QoL across all domains. Understanding these drivers may aid in identifying areas for targeted interventions, such as fracture prevention.
Costing curative outpatient care for the poorest in Burkina Faso: informing universal health coverage and leaving no one behind
Authors: Beaugé Yvonne , Ridde Valéry , Souleymane Sidibé , Kiendrébéogo Joël Arthur , Nguyen Hoa Thi , Bonnet Emmanuel , De Allegri Manuela
Published: November 2024

Introduction

The poorest in Burkina Faso face numerous barriers to healthcare access, including financial and geographic obstacles, as well as a high burden of chronic conditions and multimorbidity. This study estimates the average cost of providing curative outpatient consultations at first-level healthcare facilities to the poorest in Burkina Faso. It also estimates the budgetary impact of scaling up free access to these services nationwide. The findings provide essential evidence on cost structures to inform decision-makers in developing policies aimed at achieving universal health coverage and ensuring that no one is left behind.

Methods

We conducted a micro-costing study to estimate the economic costs of providing curative outpatient healthcare services to the poorest at first-level healthcare facilities, considering a health system perspective. We measured the consumption of capital costs (building and equipment) using survey data from 32 primary health facilities and recurrent costs (drugs and consumables) from medical records of 1380 poor patients in Diébougou district. These individuals were targeted and exempted from user fees through a community-based targeting approach. We obtained unit costs from official price lists, pharmacy registries, and expert interviews. We calculated the national budget for providing curative care services to the exempted poorest based on the average cost per first-level consultation.

Results

The estimated capital and recurrent costs of providing curative care services ranged between USD 0.59 - USD 0.61 and USD 2.58 - USD 5.00, respectively. The total cost ranged between USD 3.17 - USD 5.61 per first-level consultation. Providing curative care to the bottom 20% of the population, assuming 0.25 healthcare contacts per person per year, would result in an annual expense ranging from USD 2.77 M to USD 5.38 M (0.74-1.43% of the healthcare budget in 2019). With 2 healthcare contacts per person per year, costs increase to USD 22.19 M to USD 43.05 M (5.91-11.45% of the healthcare budget).

Conclusion

The results can inform policies aimed at expanding access to curative care for the poorest in Burkina Faso, contributing to the goals of universal health coverage and leaving no one behind. Further research is needed to enhance cost estimation and budgeting for higher-level care in the country.
Whole-genome DNA methylomes of tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulation
Authors: Son Dongmin R. , Kong Yifan , Tan Yulian , Hu Ting , Shi Lei , Yi Soojin V.
Published: November 2024

Background

The tree shrew (Tupaia belangeri) is a promising emerging model organism in biomedical studies, notably due to their evolutionary proximity to primates. To enhance our understanding of how DNA methylation is implicated in regulation of gene expression and the X chromosome inactivation (XCI) in tree shrew brains, here we present their first genome-wide, single-base-resolution methylomes integrated with transcriptomes from prefrontal cortices.

Results

Genome-wide relationships between DNA methylation and gene expression are consistent with those in other mammals. Interestingly, we observed a clear and significant global reduction (hypomethylation) of DNA methylation across the entire female X chromosome compared to male X. Female hypomethylation does not directly contribute to the gene silencing of the inactivated X chromosome nor does it significantly drive sex-specific gene expression in tree shrews. However, we identified a putative regulatory region in the 5′ end of the X-inactive-specific transcript (Xist) gene, whose pattern of differential DNA methylation strongly relate to its sex-differential expression in tree shrews. Furthermore, differential methylation of this region is conserved across different species. We also provide evidence suggesting that the observed difference between human and tree shrew X-linked promoter methylation is associated with the difference in genomic CpG contents.

Conclusions

Our study offers novel information on genomic DNA methylation of tree shrews as well as insights into the evolution of sex chromosome regulation in mammals. Specifically, we show conserved role of DNA methylation in regulation of Xist expression and propose genomic CpG contents as a factor in driving sex-differential DNA methylation of X-linked promoters.
Pin1 promotes human CaV2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2
Authors: Fu Ssu-Ju , Cheng Kai-Min , Hsiao Cheng-Tsung , Fang Ya-Ching , Jeng Chung-Jiuan , Tang Chih-Yung
Published: November 2024

Loss-of-function mutations in the human gene encoding the neuron-specific Ca2+ channel CaV2.1 are linked to the neurological disease episodic ataxia type 2 (EA2), as well as neurodevelopmental disorders such as developmental delay and developmental epileptic encephalopathy. Disease-associated CaV2.1 mutants may exhibit defective proteostasis and promote endoplasmic reticulum (ER)-associated degradation of their wild-type (WT) counterpart in a dominant-negative manner. The E3 ubiquitin ligase RNF138 was previously shown to mediate EA2-related aberrant degradation of CaV2.1 at the ER. Herein we aimed to elucidate the ER proteostasis mechanism of CaV2.1. The peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 (Pin1) was identified as a novel neuronal CaV2.1 binding partner that promoted polyubiquitination and proteasomal degradation of CaV2.1. Suppression of endogenous Pin1 level with either shRNA knockdown or the Pin1 inhibitor all-trans retinoic acid (ATRA) enhanced endogenous CaV2.1 protein level in neurons, and attenuated ER-associated degradation of CaV2.1 WT and EA2-causing mutants. Detailed mutation analyses suggested that Pin1 interacted with specific phosphorylated serine/threonine-proline motifs in the intracellular II-III loop and the distal carboxy-terminal region of human CaV2.1. We further generated Pin1-insensitive CaV2.1 constructs and demonstrated that, during ER quality control, Pin1 served as an upstream regulator of CaV2.1 polyubiquitination and degradation by RNF138. Pin1 regulation was required for the dominant-negative effect of EA2 missense mutants, but not nonsense mutants, on CaV2.1 WT protein expression. Our data are consistent with the idea that CaV2.1 proteostasis at the ER, as well as dominant-negative suppression of disease-causing loss-of-function mutants on CaV2.1 WT, entail both Pin1/RNF138-dependent and -independent mechanisms.
NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice
Authors: Tu Haitao , Yeo Xin Yi , Zhang Zhi-Wei , Zhou Wei , Tan Jayne Yi , Chi Li , Chia Sook-Yoong , Li Zhihong , Sim Aik Yong , Singh Brijesh Kumar , Ma Dongrui , Zhou Zhidong , Bonne Isabelle , Ling Shuo-Chien , Ng Adeline S.L. , Jung Sangyong , Tan Eng-King , Zeng Li
Published: November 2024

Background

The expansion of GGC repeats (typically exceeding 60 repeats) in the 5’ untranslated region (UTR) of the NOTCH2NLC gene (N2C) is linked to N2C-related repeat expansion disorders (NREDs), such as neuronal intranuclear inclusion disease (NIID), frontotemporal dementia (FTD), essential tremor (ET), and Parkinson’s disease (PD). These disorders share common clinical manifestations, including parkinsonism, dementia, seizures, and muscle weakness. Intermediate repeat sizes ranging from 40 to 60 GGC repeats, particularly those with AGC-encoded serine insertions, have been reported to be associated with PD; however, the functional implications of these intermediate repeats with serine insertion remain unexplored.

Methods

Here, we utilized cellular models harbouring different sizes of N2C variant 2 (N2C2) GGC repeat expansion and CRISPR-Cas9 engineered transgenic mouse models carrying N2C2 GGC intermediate repeats with and without serine insertion to elucidate the underlying pathophysiology associated with N2C intermediate repeat with serine insertion in NREDs.

Results

Our findings revealed that the N2C2 GGC intermediate repeat with serine insertion (32G13S) led to mitochondrial dysfunction and cell death in vitro. The neurotoxicity was influenced by the length of the repeat and was exacerbated by the presence of the serine insertion. In 12-month-old transgenic mice, 32G13S intensified intranuclear aggregation and exhibited early PD-like characteristics, including the formation of α-synuclein fibers in the midbrain and the loss of tyrosine hydroxylase (TH)-positive neurons in both the cortex and striatum. Additionally, 32G13S induced neuronal hyperexcitability and caused locomotor behavioural impairments. Transcriptomic analysis of the mouse cortex indicated dysregulation in calcium signaling and MAPK signaling pathways, both of which are critical for mitochondrial function. Notably, genes associated with myelin sheath components, including MBP and MOG, were dysregulated in the 32G13S mouse. Further investigations using immunostaining and transmission electron microscopy revealed that the N2C intermediate repeat with serine induced mitochondrial dysfunction-related hypermyelination in the cortex.

Conclusions

Our in vitro and in vivo investigations provide the first evidence that the N2C-GGC intermediate repeat with serine promotes intranuclear aggregation of N2C, leading to mitochondrial dysfunction-associated hypermyelination and neuronal hyperexcitability. These changes contribute to motor deficits in early PD-like neurodegeneration in NREDs.
Allergic rhinitis management: a Delphi Consensus promoted by the Italian Society of Pediatric Allergy and Immunology (SIAIP)
Authors: Miraglia del Giudice Michele , Marseglia Gian Luigi , Peroni Diego G. , Zicari Anna Maria , Dinardo Giulio , Ciprandi Giorgio
Published: November 2024

Allergic rhinitis (AR) is the most frequent IgE-mediated disease, mainly in children and adolescents. Management of AR in the pediatric age may be heterogeneous, and the available guidelines do not adequately consider this issue. As a result, the Italian Society of Pediatric Allergy and Immunology (SIAIP) promoted a Delphi Consensus to define and evaluate the most relevant aspects of AR management in the pediatric setting in Italy. A qualified board of experts prepared a list of statements that a panel of Italian experts voted on using a web platform. Forty-two pediatricians participated. The results showed that all statements had consensus (> 80% of scores 4 + 5). In particular, there was awareness that AR is a type 2 inflammatory disease requiring adequate treatment. Topical drugs should be preferred, as they are better with cycles. Combined antihistamine/corticosteroid is also considered effective and safe in adolescents. In conclusion, AR deserves adequate attention and care. Current medications are safe and effective; treatment should be addressed to dampen type 2 inflammation and relieve complaints.
Emerging models of human and non-human primate placental development – Centre for Trophoblast Research 17th annual meeting 2024
Authors: Aye Irving L. M. H.
Published: November 2024

The 17th annual meeting of the Centre for Trophoblast Research (CTR) took place at the University of Cambridge, UK, on 1-2 July 2024. This year's meeting provided an opportunity to reflect on the significant advancements made recently in modelling the human placenta in vitro. The meeting featured 12 invited speakers and attracted 260 participants from 25 countries. Many of the speakers were leading figures who have developed methods to derive human trophoblast stem cells or organoids from first trimester and term placentas, and from pluripotent stem cells. Accompanying the invited presentations were flash talks selected from the abstract submissions and poster presentations. The meeting concluded with a stimulating panel discussion to evaluate the current human trophoblast models. This Meeting Review aims to capture the spirit of the event and highlight the key themes and take-home messages that emerged.
Confrontation experience against escaping bait improves pursuit strategy in mice
Authors: Wang Jincheng , Zhang Yueting , Lv Songyan , Pang Ruiqi , Zhang Yanjie , Liu Xue , Deng Qiyue , Zhou Yi
Published: November 2024

Confrontations between predator and prey, driven by the innate survival instincts in both predator and prey, constitute the most significant form of competition in evolution. Yet, understanding how survival skills can benefit from such confrontations remains limited, despite its critical importance for animal survival. We have developed an interactive platform to investigate confrontations between a hungry mouse and an escaping bait. This robotic bait is controlled magnetically through a closed-loop system to continually evade the approaching mouse. Meanwhile, the mouse must capture the escaping bait to receive a food reward. Through analysis of angles, speeds and other kinematic parameters of both the mouse and the bait, we observed that confrontation experiences can notably enhance mice performance. Compared with novice mice, veteran mice enhanced predation efficiency primarily by optimizing the pursuit phase, significantly reducing time costs, mainly by minimizing pauses in movement. Additionally, experience strengthened the navigation strategies used by mice to better track evading bait. Finally, we validated the impact of empirically induced changes in speed distribution and pursuit methods on predation efficiency through modeling of the pursuit phase. In conclusion, this study reveals that confrontation experience could improve pursuit strategy in mice by altering the speed control and pursuit method, providing new insights into these crucial behavioral interactions in nature.
Mari Elen vive!
Authors: Encarnação Ana Isabela Gil de Brito da , Vieira Guilherme Costa , Melo Juliana de Almeida , Silva Rosenilda Freitas da
Published: November 2024

Este caso aborda a situação de múltiplas opressões vivenciadas por uma mulher negra, bissexual, pobre, que encontrou, ao longo da sua trajetória de vida, uma série de barreiras para o sucesso profissional e pessoal. Vinda de uma família de baixa renda, foi por meio da política de cotas raciais e sociais que a personagem principal teve a chance de ingressar no ensino superior, em que teve um desempenho de excelência. Foi também beneficiada com a política de cotas quando resolveu prestar concurso público para um cargo na carreira jurídica. No entanto, ao longo de sua trajetória, a personagem pôde perceber as limitações da política de cotas em um país com o histórico de patrimonialismo, misoginia e racismo como é o Brasil, o que impede a plena inclusão social de populações historicamente marginalizadas.
Desenvolvimento de simulador de baixo custo para ensino em cricotireoidostomia
Authors: Tavares Fernandes Vieira Francisco Matheus , Martins Neto Francisco , Cesar Silva Oliveira Leonardo , Valente Acrisio
Published: November 2024

Introdução: A cricotireoidostomia é um procedimento pouco realizado e que costuma ser feito em situações de estresse pois, comumente, é indicado quando não se consegue estabelecer uma via aérea adequada em situações de insuficiência respiratória, condições que prejudicam o treinamento. Objetivo: Desenvolvimento de um simulador de fácil replicação e baixo custo para o ensino na técnica da cricotireoidostomia. Método: Para o desenvolvimento do simulador foi pensando em 3 conceitos fundamentais: baixo custo de fabricação, facilidade de replicabilidade e realismo. Após a realização de pesquisa sobre modelos tridimensionais existentes, definiu-se pelo desenvolvimento de um simulador realístico e funcional em impressora tridimensional baseado em partes anatômicas reais através de modelo tomográfico. Diversos testes relacionados à impressora, material e funcionalidade foram realizados para a definição da concepção final.  Resultados: O produto final foi um simulador realístico impresso em impressora de filamento com movimento em 3 eixos, sendo composto por modelo representando parte inferior da face com o mento, região cervical e início do tórax em tamanho real, placa removível e intercambeável representando modelos de cartilagens tireóide e cricóide com membrana cricotireóide e pele, sendo estas duas partes descartáveis. Os materiais empregados no simulador foram ácido polilático, poliuretano termoplástico, borracha de silicone e esparadrapo impermeável. O conjunto foi disposto em base sintética emborrachada. Todo o modelo levou cerca de 70 horas para ser construído e teve custo final de materiais inferior à R$ 150,00. Conclusão: Foi desenvolvido um simulador mecânico para treinamento em cricotireoidostomia de aspecto realístico, baixo custo e simples construção.
Biópsia hepática videoassistida com dispositivo minimamente invasivo: desenvolvimento e validação de técnica
Authors: Mano Almeida Alexandra , Alexandre Lima Rocha Hermano , Da Silva de Oliveira Borges Tarsila Alice , De Barros Silva Paulo Goberlânio , Borges Gleydson
Published: November 2024

A biópsia hepática percutânea é a técnica padrão-ouro para o estabelecimento de doenças hepáticas. Alguns casos de doenças crônicas do fígado apresentam elevados casos de falso negativos nas amostras obtidas por via percutânea. Isso justifica a realização de biópsia hepática por via laparoscópica. O objetivo deste trabalho é desenvolver uma técnica videoassistida que utilize apenas um dispositivo minimamente invasivo para biópsia hepática e o portal da ótica. Sem trocarteres adicionais, essa técnica traz uma proposta menos invasiva que as técnicas existentes na prática clínica. Este é um estudo de desenvolvimento e validação de dispositivo e foram recrutados pacientes que se submeteram a uma videocirurgia abdominal e necessitaram de biópsia hepática por esteatose moderada a severa. Todos os pacientes assinaram TCLE. Os pacientes foram randomizados em dois grupos: técnica de biópsia hepática por laparoscopia (n = 10, grupo controle) e técnica de biópsia hepática por minilaparoscopia (n = 8, grupo experimental). Avaliou-se os tempos associados a realização do procedimento nos dois grupos com testes de Mann-Whitney ou Kruskal-Wallis devido à distribuição dos dados. No baseline, não houve diferença estatística em relação ao sexo e ao tipo de cirurgia. O grupo experimental apresentou tempo significativamente menor em relação ao tempo médio do procedimento (p = 0,003), tempo de biópsia (p = 0,002) e tempo de hemostasia (p = 0,003). O dispositivo e técnica de biópsia por minilaparoscopia mostraram-se capazes de obter amostra de tecido suficiente e de forma segura, minimamente invasiva e em menor tempo de execução que a técnica clássica.
Aplicativo de protocolo para atendimento de pacientes pediátricos com cetoacidose diabética
Authors: Alencar Priscila , PAIVA MARQUES LIMA ROLIM JULIANA
Published: November 2024

A cetoacidose diabética é caracterizada por um quadro de hiperglicemia associada a um aumento na produção de corpos cetônicos. É uma emergência pediátrica muito relevante, causa mais comum de hospitalização e morte em crianças diabéticas. O diagnóstico tardio pode levar a complicações graves. O desenvolvimento de um aplicativo pode contribuir para o melhor atendimento dos pacientes diabéticos, evitando complicações, tempo de internação e custos, sendo o objetivo do trabalho Assim, foi desenvolvido um aplicativo nas duas principais plataformas móveis existentes: Android e iOS. O aplicativo foi disponibilizado na língua portuguesa. Seus vários módulos são apresentados em uma formato prático, facilitando o diagnóstico, o tratamento e as complicações da doença. É composto por vários parâmetros que podem ser utilizados, levando a diferentes passos sequenciais, conduzindo assim a um raciocínio clínico, desde fluxogramas, tabelas, definição, fisiopatologia, diagnóstico clínico e laboratorial, classificações, tratamento e sua cronologia, prevenção, orientações das complicações após resolução da cetoacidose e orientações gerais, como os tipos de insulina, os insumos necessários e horários específicos para realização da glicemia capilar. A importância do trabalho reside no método de diagnóstico protocolado que oriente as primeiras medidas terapêuticas a serem tomadas, de forma a instituí-las o mais precoce possível, minimizando as possíveis complicações. O aplicativo está pronto para teste, podendo possibilitar ao profissional uma melhor condução de pacientes pediátricos com suspeita de cetoacidose diabética.
Percepção de docentes, discentes e egressos do curso de Farmácia sobre a avaliação através do Objective Structured Clinical Examination (OSCE).
Authors: Barbosa da Silva Gomes Elisangela Christhianne , Malaquias da Silva Freitas Luanne , Nóbrega de Albuquerque Adelaide , Morais de Medeiros Flávia Patrícia
Published: November 2024

Descrever a percepção dos docentes e discentes/egressos sobre a utilização do Objective Structured Clinical Examination (OSCE) no curso de farmácia de uma instituição no Nordeste do Brasil. Trata-se de um estudo descritivo e exploratório com abordagem qualitativa. A coleta de dados foi realizada por meio de entrevista individualizada. Para análise dos dados foi utilizada a análise de conteúdo de Bardin, da qual emergiram quatro categorias: processo de ensino-aprendizagem; alcance dos objetivos de aprendizagem; contribuição para a formação profissional e sentimentos durante a avaliação. Participaram cinco docentes, quatro egressos e 19 discentes. Através da percepção das entrevistas, o OSCE contribui para o desenvolvimento do equilíbrio psicoemocional e ambiental do discente, a fim de reduzir suas ansiedades acerca da aplicação, na prática profissional, dos conhecimentos abordados na graduação e promoveu uma maior segurança para os egressos na resolução de problemas.
Percepção de Docentes Acerca do Uso da Inteligência Artificial na Formação Médica
Authors: Ferreira de Macêdo Andreza , Moura Ramos Mônica , Martins de Farias Neto Pedro , Barros de Lorena Suélem
Published: November 2024

A Inteligência Artificial refere-se ao desenvolvimento de sistemas computacionais programados para simular processos de inteligência humana, como aprendizagem, raciocínio e percepção. Na educação médica, essa tecnologia apresenta um potencial transformador, possibilitando experiências de aprendizagem personalizadas e adaptáveis. Contudo, seu uso levanta debates éticos e desafios importantes. Este trabalho analisou a percepção de docentes sobre essa ferramenta na formação médica, considerando suas vantagens, os desafios e a necessidade de capacitação. O estudo, realizado em faculdade pernambucana privada, com 63 docentes respondendo a questionários online, revelou que 77,8% enxergam a inteligência artificial como uma vantagem no ensino médico, destacando a personalização e o aprendizado adaptativo como os principais benefícios. No entanto, 63,5% manifestaram preocupação com uma possível desumanização do ensino, e 22,2% apontaram o risco de elitização. Os resultados ressaltam a importância da capacitação contínua, uma vez que 95% dos participantes desejam treinamento específico para esse recurso, e 78% se consideram despreparados para usar a tecnologia em sala de aula. Conclui-se que, para enriquecer a formação médica com inteligência artificial, é fundamental oferecer suporte adequado e preservar aspectos como a humanização e o desenvolvimento do pensamento crítico.
A utilização do prontuário eletrônico no cuidado em saúde e o seu impacto na relação médico-paciente
Authors: COSTALIMAFILHO JOSECELIO , Khaellyny Jaêdra Marques Arruda Rosário Curvello  , Raphael Reis Cruz Moraes  , Willas Ferreira Furtado  , Ana Luise Almeida da Cunha  , Claudia Maria Costa de Oliveira
Published: November 2024

A utilização do Prontuário Eletrônico do Paciente (PEP) tem transformado a prática médica, ao substituir os registros em papel por sistemas digitais, facilitando o acesso rápido e seguro aos dados de saúde e promovendo uma maior integração dos sistemas de saúde. Este artigo revisa a literatura sobre a utilização do PEP, abordando vantagens como eficiência administrativa, segurança dos dados e melhor gerenciamento do cuidado, bem como desvantagens que incluem custos de implementação, resistência dos usuários e possíveis efeitos na interação médico-paciente.A metodologia adotada foi uma revisão bibliográfica de artigos de 2018 a 2024, utilizando descritores específicos para analisar os impactos do PEP. Os resultados indicam que o PEP promove agilidade no atendimento e facilita o acesso ao histórico do paciente, o que é valorizado pela maioria dos profissionais. Contudo, em ambientes de atenção primária, alguns médicos relatam que o PEP pode prejudicar o vínculo com o paciente, ao introduzir uma “terceira pessoa” na consulta, limitando o contato visual e a interação direta.A análise dos artigos sugere que, apesar de o PEP ser amplamente aceito e essencial para a qualidade do cuidado, a sua implementação exige aprimoramentos, como padronização, treinamento técnico e regulamentação da privacidade e segurança. Para uma adoção mais eficiente, são necessárias estratégias que promovam um emprego mais humano e facilitador do PEP, conciliando o manuseio da tecnologia com o fortalecimento da relação médico-paciente.
Improving driver safety tolerance zone through holistic analysis of road, vehicle and behavioural risk factors
Authors: Μιχελαράκη Ευανθία
Published: November 2024

Η οδική ασφάλεια αποτελεί ένα πολύπλοκο ζήτημα που επηρεάζεται από ένα ευρύ φάσμα παραγόντων, συμπεριλαμβανομένων των συνθηκών της οδού, των χαρακτηριστικών του οχήματος και της συμπεριφοράς του οδηγού. Στόχος της παρούσας διδακτορικής διατριβής ήταν η βελτίωση της Ζώνης Ανοχής Ασφάλειας (STZ) του οδηγού μέσω μιας ολιστικής ανάλυσης των παραγόντων κινδύνου της οδού, του οχήματος και της συμπεριφοράς. Πιο συγκεκριμένα, εξετάστηκε η επιρροή της πολυπλοκότητας του έργου της οδήγησης και της ικανότητας αντιμετώπισης στον κίνδυνο ατυχήματος. Για τον σκοπό αυτό, αξιοποιήθηκαν δεδομένα από 190 οδηγούς που συμμετείχαν σε ένα μεγάλο πείραμα σε πραγματικές συνθήκες οδήγησης καθώς και σε προσομοιωτή. Αναπτύχθηκε και εφαρμόστηκε μια καινοτόμος μεθοδολογία, η οποία αποτελούνταν από αναλύσεις στατιστικής και μηχανικής μάθησης, συμπεριλαμβανομένων Γενικευμένων Γραμμικών Μοντέλων (GLMs), Μοντέλων Δομικών Εξισώσεων (SEMs), Νευρωνικών Δικτύων (NNs), Δέντρων Αποφάσεων (DTs), Τυχαίων Δασών (RFs) και K-Κοντινότερων Γειτόνων (kNNs). Τα SEM έδειξαν ότι η πολυπλοκότητα του έργου της οδήγησης συσχετίζεται θετικά με τον κίνδυνο, υποδεικνύοντας ότι η οδήγηση κατά τη διάρκεια της νύχτας ή υπό δυσμενείς καιρικές συνθήκες μπορεί να επιδεινώσει τις προκλήσεις που θέτουν οι πολύπλοκες εργασίες, αυξάνοντας περαιτέρω την πιθανότητα ατυχήματος. Αντίθετα, η ικανότητα αντιμετώπισης συσχετίστηκε αρνητικά με τον κίνδυνο, υποδεικνύοντας ότι οι οδηγοί με υψηλότερη ικανότητα αντιμετώπισης είναι καλύτερα εξοπλισμένοι για να αντιμετωπίσουν δύσκολες καταστάσεις κατά τη διάρκεια της οδήγησης. Τα αποτελέσματα έδειξαν ότι τα μοντέλα RF υπερείχαν των μοντέλων DT και kNN, καθιστώντας τα πιο αποτελεσματικά για την πρόβλεψη της ταχύτητας και της απόστασης από το προπορευόμενο όχημα, με συνολική ακρίβεια έως και 90%. Τα NN έδειξαν ότι το επίπεδο STZ μπορεί να προβλεφθεί με εξαιρετική ακρίβεια έως και 89,8%. Τέλος, τα πειράματα σε προσομοιωτή αποδείχθηκαν τα καταλληλότερα για την πρόβλεψη των επιπέδων STZ και ότι τα νατουραλιστικά δεδομένα, χωρίς επικύρωση με προσομοιωτή, ενδέχεται να μην διαθέτουν τις ελεγχόμενες συνθήκες που απαιτούνται για την ενδελεχή αξιολόγηση πολύπλοκων αλληλεπιδράσεων. Συνολικά, αποκαλύφθηκε ότι τόσο οι παρεμβάσεις σε πραγματικό χρόνο όσο και μετά το ταξίδι είχαν θετική επίδραση στην οδηγική συμπεριφορά, καθώς οι συμμετέχοντες κατάφεραν να βελτιώσουν τις επιδόσεις τους. Η ολοκληρωμένη αντιμετώπιση της πολυπλοκότητας των καθηκόντων, της ικανότητας αντιμετώπισης και του κινδύνου μπορεί να βελτιώσει τη συμπεριφορά και την ασφάλεια όλων των χρηστών της οδού, μέσω της διακριτικής και απρόσκοπτης παρακολούθησης της οδηγικής συμπεριφοράς.
Structure of BiHom-pre-Poisson algebras
Authors: Aloulou Walid , Jebli Mansour
Published: November 2024

In the current research paper, we define and investigate the structure of a BiHom-pre-Poisson algebra. This algebraic structure is defined by two products "Λ", "◊" and two linear maps f, g on A. In particular, (A, Λ, f, g) is a BiHom-Zinbiel algebra and (A, ◊, f, g) is a BiHom-pre-Lie algebra. Additionally two compatibility conditions between Λ and ◊ are verified. Our first main results are devoted to demonstrating that if A is a BiHom-pre-Lie algebra, then a tensorial algebra of A has a structure of a BiHom-pre-Poisson algebra. Furthermore, we prove that any BiHom-Poisson algebra together with a Rota–Baxter operator defines a BiHom-pre-Poisson algebra. Finally, we define the structure of a dual BiHom-pre-Poisson algebra and we demonstrate that an averaging operator on a BiHom-Poisson algebra gives rise to a dual BiHom-pre-Poisson algebra.
The discrete Hardy type variable exponent inequality with decreasing exponent
Authors: Castillo René , Chaparro Hector , Sultan Babar
Published: November 2024

The purpose of this note is to obtain the discrete Hardy type variable exponent inequality for the decreasing exponent.
From Yamabe to almost contact metric structure
Authors: Beldjilali Gherici , Delloum Adel
Published: November 2024

The investigation of Yamabe solitons within almost contact metric manifolds has garnered significant interest recently, producing notable findings. This paper aims to explore the inverse problem: constructing almost contact metric structures on a three-dimensional Riemannian manifold endowed with an almost Yamabe soliton. Subsequently, we provide the techniques required to characterize the nature of these structures, accompanied by concrete examples.
Mütter mit Zuwanderungsgeschichte. Ihre Erwerbs- und Sorgearbeit, Geschlechternormen und schulischen Unterstützungsleistungen
Authors: Gambaro Ludovica , Gutu Lidia , Schmitz Sophia , Spieß C. Katharina , Ziege Elena
Published: November 2024

Die Publikation fasst die Ergebnisse eines zweijährigen Forschungsprojekts zusammen, das sich mit wichtigen Fragestellungen der Sorge- und Erwerbstätigkeit von Müttern und Frauen mit Zuwanderungsgeschichte befasst.
Konieczność rewolucji? Marksiści francuscy wobec wydarzeń maja i czerwca 1968
Authors: Winkler Anna
Published: November 2024

Wydarzenia maja i czerwca 1968 roku – fala protestów i strajków, która pociągnęła za sobą nawet dziesięć milionów ludzi z różnych klas i warstw społecznych – rozbudziły w społeczeństwie francuskim nadzieje na dokonanie radykalnej zmiany. Zwiastowały ją hasła, które pojawiały się na studenckich i (w mniejszym stopniu) robotniczych sztandarach, takie jak „Cała władza w ręce rad” czy „Trzeba znieść społeczeństwo klasowe”. Rewolucyjny język, dotychczas używany jedynie przez frakcje goszystowskie, stanowiące lewicową opozycję wobec Francuskiej Partii Komunistycznej, pojawił się nagle w centrum publicznej debaty. Przez kilka dni wydawało się, że Francja znajduje się u progu rewolucji.

Goszyści, którym protesty przywróciły zachwianą w pierwszej połowie dekady wiarę w możliwość głębokiego przeobrażenia społeczeństwa francuskiego, podjęli w maju i czerwcu starania, by zaproponować odpowiadający duchowi czasu model rewolucji. Mieścił się on w tradycji marksistowskiej, ale wyrażał idee, które nie tylko były obce systemowi kapitalistycznemu, ale także pozostawały w sprzeczności z podtrzymywanym przez partię komunistyczną modelem stalinowskim. Konieczność rewolucji? Marksiści francuscy wobec wydarzeń maja i czerwca 1968 to książka, która prowadzi przez zagmatwany labirynt goszystowskich interpretacji, umieszczając je na szerokim tle przemian społeczno-politycznych i ideowych Francji lat 50. i 60. i pokazując, jak zerwanie z dwiema dominującymi dotychczas w społeczeństwie francuskim narracjami (komunistyczną i gaullistowską) pomogło wyrazić Francuzom ich niezadowolenie, a także sformułować nowe żądania dotyczące otaczającej ich rzeczywistości.
Dylemat więźnia. Ostracyzm ateński i jego pierwotne cele
Authors: Węcowski Marek
Published: November 2024

Książce tej przyświeca przekonanie, że dotychczasowe wyjaśnienia mechanizmów działania oraz genezy ateńskiego ostracyzmu są niewystarczające. Mało miejsca poświęca się w niej słynnym ostrakom, czyli ceramicznym skorupom, na których Ateńczycy skrobali imiona nielubianych polityków. Zdaniem autora tym narzędziom ateńskiego ostracyzmu i momentowi głosowania nad wygnaniem jednego z polityków przypisuje się nadmierne znaczenie, zaniedbując inne aspekty i pozostałe etapy długotrwałej procedury.

Zadano tu serię nowych albo względnie nowych pytań. Jedno z nich nigdy dotąd nie zostało jasno w nauce postawione: jak wytłumaczyć to, że dla kilkudziesięcioletnich dziejów ostracyzmu dowiadujemy się o zaledwie kilkunastu skutecznych przypadkach jego zastosowania? I jakie wnioski mogą z tego wynikać dla badania tej instytucji?

Główną tezą książki jest interpretacja ateńskiego ostracyzmu jako mechanizmu wymuszającego kompromis w środowisku ateńskich elit politycznych. Dla potrzeb takiego wywodu skorzystano z narzędzi teorii „ewolucji kooperacji”, sformułowanej przez politologa i matematyka Roberta Axelroda na podstawie tzw. Iterowanego dylematu więźnia.
Teoria krytyczna szkoły budapeszteńskiej
Authors: Bulira Waldemar
Published: November 2024

Książka prezentuje losy oraz twórczość emigracyjną węgierskich filozofów: Ágnes Heller, Ferenca Fehéra, Györgya Márkusa oraz Mihálya Vajdy, uczniów, wychowanków i współpracowników markisty Györgya Lukácsa. Grupa ta, zmuszona przez władze komunistyczne do wyjazdu z Węgier pod koniec lat 70. XX wieku, przeszła do historii światowej humanistyki pod nazwą szkoły budapesztańskiej. Analizy myśli jej głównych członków pozwalają dostrzec, że wpisuje się ona w szeroko rozumianą tradycję teorii krytycznej, a także umożliwiają uchwycenie charakteru jej ewolucji. Przedmiot zainteresowań budapeszteńskich myślicieli stanowiły kolejne wytwory nowoczesności niosące ze sobą zagrożenia dla wolności jednostki, których spektrum wyznaczają tytułowe kategorie totalitaryzmu oraz postmodernizmu. Rekonstrukcja zawiłych losów bohaterów książki – intelektualistów na wygnaniu par excellence – oraz krytyczna analiza porównawcza ewolucji ich poglądów zostały wzbogacone o obszerne i z rozmachem nakreślone konteksty teoretyczne, historyczne i polityczne, w których owe losy i ewolucja się dokonywały. Dzięki temu książka wnosi również wkład w zrozumienie sensu doświadczeń jednostkowych i grupowych mieszkańców Europy Środowo-Wschodniej w XX wieku.
Recepcja twórczości Samuela Becketta w Polsce
Authors: Brzeska Ewa
Published: November 2024

Recepcja twórczości Samuela Becketta w Polsce to publikacja o doniosłym znaczeniu. Jest pierwszym systematycznym opracowaniem tematu, jakie ukazało się od 1990 roku, i stanowi punkt zwrotny. Siedemdziesiąt lat obecności Becketta w polskiej kulturze nakreśla dostatecznie szeroką perspektywę, aby stwierdzić, że współcześni przestają patrzeć na niego z pozycji karła. Piedestał, na którym zwykło się go umieszczać, burzą nawet ci, co go wznieśli. Czyżby w tej partii szachów po raz pierwszy powiedziano pisarzowi: mat?

Bezcennym walorem książki są rozbudowane aneksy, w których zgromadzono informacje o wszystkich polskich inscenizacjach i utworach muzycznych inspirowanych tekstami Becketta. Skompilowano w nich także wykaz festiwali i seminariów beckettowskich. W części bibliograficznej czytelnik odnajdzie ponadto nigdy wcześniej niepublikowany, kompletny spis dzieł autora oraz listę ich przekładów na język polski.