bluuebunny/crossref_metadata_2025 huggingface dataset:
HIGH GAIN BROADBAND INTEGRATED AMPLIFIER FOR INSTANTANEOUS FREQUENCY MEASUREMENT IC
Authors:   Omsk State Technical University, Omsk, Russia, Lyashuk A. N. , Puzyrev P. I. ,   Omsk State Technical University, Omsk, Russia, Zavyalov S. A. ,   Omsk State Technical University, Omsk, Russia, Sadykov Z. B. ,   Omsk State Technical University, Omsk, Russia
Published: May 2024

The article describes the design of a broadband integrated amplifier-limiter. The results of simulation of the developed amplifier topology in the GaAs 150 nm process with a gain of over 80 dB are presented. A distinctive feature of the amplifier is the implementation of a multi-stage structure, which allows you to increase the gain and get an amplifier with a gain of tens of decibels. The amplifier has a large frequency band in the range from 1 to 8 GHz. In contrast to the implementation of such solutions on lumped components, the proposed IC topology can significantly reduce the weight and size parameters.
HIGH PERFORMANCE MODEM FOR UNDERWATER COMMUNICATION SYSTEMS
Authors:   Omsk State Technical University, Omsk, Russia, Khazan V. L. , Myshkin V. F. ,   Tomsk Polytechnic University, Tomsk, Russia, Pavlov I. I. ,   Siberian state University of telecommunications and Information Science, Novosibirsk, Russia, Khan V. A. ,   Tomsk Polytechnic University, Tomsk, Russia,   Institute of Atmospheric Optics named after Academician V.E. Zuev SB RAS, Tomsk, Russia, Zavyalov M. S. ,   Omsk State Technical University, Omsk, Russia,   Omsk Scientific Research Institute of Instrument Making, Omsk, Russia
Published: May 2024

The algorithm of operation of the modem with increased energy efficiency with quadrature intrapulse phase modulation (QIPPM) in radio lines using extremely low frequencies for underwater communication is described. In this case, the increase in energy efficiency of the modem with QIPPM is achieved by reducing its frequency efficiency and introducing additional code redundancy. This allows for a 2-fold increase in depth for underwater communication. At the same time the probability of erroneous reception of code combinations is reduced to a minimum.
CONTRIBUTION OF THERMAL EMISSION TO THE CHARGE CONCENTRATION IN A LASER BEAM PROPAGATING THROUGH AN AEROSOL
Authors:   Institute of Atmospheric Optics named after Academician V.E. Zuev SB RAS, Balandin S. F. , Donchenko V. A. ,   V. D. Kuznetsov Siberian Physical-Technical Institute at Tomsk State University, Tomsk, Russia, Myshkin V. F. ,   Tomsk Polytechnic University, Tomsk, Russia, Pavlov I. I. ,   Siberian state University of telecommunications and Information Science, Novosibirsk, Russia, Khazan V. L. ,   Omsk State Technical University, Omsk, Russia, Khan V. A. ,   Institute of Atmospheric Optics named after Academician V.E. Zuev SB RAS,   Tomsk Polytechnic University, Tomsk, Russia
Published: May 2024

Physical processes occurring in aerodisperse media with solid particles during thermal emission of electrons from the particle surface and primary optical breakdown are considered. The possibility of weak ionization of the air medium at a distance of several centimeters from the breakdown center is shown, due to the ionization of NO molecules and the course of a number of thermochemical reactions suitable for use in a long laser spark.
AN IDENTIFICATION OF VARIETIES OF SINGLE-MODE OPTICAL FIBERS AND DETERMINATION OF THEIR LONGITUDINAL TENSION CHARACTERISTICS
Authors:   Omsk State Technical University, Omsk, Russia, Bogachkov I. V. , Gorlov N. I. ,   Siberian State University of Telecommunications and Computer Science, Novosibirsk, Russia
Published: May 2024

This paper presents the results of studies on the automation of the processing of measurements of Brillouin reflectograms containing various types of single-mode optical fibers. By analyzing the Mandelstam-Brillouin scattering parameters, it is possible to distinguish the varieties of optical fibers in the studied optical cables, as well as to estimate the change in Brillouin frequency shift and determine the degree of longitudinal tension. The initial values of the Brillouin frequency shift and the Mandelstam-Brillouin scattering spectrum for each type of optical fiber differ. Developed programs for processing Blilluen reflectograms are presented. Conclusions were made about the accuracy of estimates obtained according to various algorithms, based on the accumulated experience in working with the presented programs.
ALGORITHM FOR RANKING WIRELESS SENSOR NETWORK NODES WITH THEIR RANDOM SPATIAL DISTRIBUTION
Authors:   Omsk State Transport University, Omsk, Russia, Bychkov E. D. , Maistrenko V. A. ,   Omsk State Technical University, Omsk, Russia
Published: May 2024

The method of making a decision on the ranking of sensor nodes in a wireless sensor network randomly distributed on a certain plane, which operates in a constantly changing network environment, is considered. As a priori information about the network environment, expertise is used, framed in the form of a matrix of utility relations. The given matrix is filled with integer point estimates. The solution to the ranking of base stations is a calculated a posteriori fuzzy set. A numerical example of solving the problem is considered.
“THE FIRST PHILOSOPHY” PROJECT IN M. M. BAKHTIN’S WORK
Authors: Arapova А. Elmira
Published: May 2024

The article considers the main ideas of M. M. Bakhtin about the first philosophy, shows the connection between Bakhtin’s philosophy and philosophical and anthropological innovations in the humanities of the 20th century, reveals Bakhtin’s views on the causes of the crisis of philosophy and action, and determines the subject and tasks of the first philosophy.
THE POLITICAL DIMENSION OF AESTHETICS: WHAT CAN PRACTICAL AESTHETICS DO FOR THE CONTEMPORARY WORLD?
Authors: Rybakov Vsevolod V.
Published: May 2024

The article considers the expediency of using the ideas of contemporary practical aesthetics in the political action necessary for solving the political and ecological crisis of our time. It is postulated that overcoming the exploitative attitude in human relations with the world is impossible without transforming our desires, aesthetic feelings and habits, which determine everyday actions more directly than reason or duty. As an alternative to the model of aesthetic experience accompanying the logic of consumption, it is proposed to actualise the deliberative component inherent in aesthetics itself, as well as to use the groundwork of Yuriko Saito’s “aesthetics of care”, which considers openness and compliance to life as the central aesthetic value. It is concluded that the ideas of contemporary practical aesthetics should form the basis of the grassroots political movement needed to effectively address the problems of our time.
“SAVAGE DEMOCRACY” BY C. LEFORT AND M. ABENSOUR
Authors: Shushpanov Evgenii S.
Published: May 2024

The article examines one of the interpretations of radical democracy, which in the works of C. Lefort was called “savage democracy”. Based on the analysis of the historical development of political regimes of the modern era, Lefort comes to the conclusion that the victory of democracy is not a historical necessity. He proposes to go beyond the understanding of democracy as an established political regime and think of it as a constant conflict of political forces. M. Abensour reveals the term “savage democracy” as the power of people, manifested in the actions of people at the moment of historical rupture. At such moments political institutions are reestablished, and new political languages reflecting the interests of participants in popular movements are formulated.
Synthesis of zirconium(IV) and hafnium(IV) isopropoxide, sec-butoxide and tert-butoxide
Authors: Dhaene Evert , Seno Carlotta , De Roo Jonathan
Published: May 2024

We revisited the synthesis of zirconium(IV) and hafnium(IV) alkoxides, namely the metal isopropoxide isopropanol complex (M(OiPr)4.iPrOH, M = Zr, Hf) and the metal sec- and tert-butoxide (M(OsBu)4 and M(OtBu)4, M = Zr, Hf). We optimized the most convenient synthesis methods and compared the products with commercial sources. En route to the metal sec- and tert-butoxides, we synthesized the metal diethylamido complex (M(NEt2)4, M = Zr, Hf).
First and Second Reductions in an Aprotic Solvent: Comparing Computational and Experimental One-electron Reduction Potentials for 345 Quinones
Authors: El Hajj Sarah , Gozem Samer
Published: May 2024

Using reference reduction potentials of quinones recently measured relative to the saturated calomel electrode (SCE) in N,N-dimethylformamide (DMF), we benchmark absolute one-electron reduction potentials computed for 345 Q/Q●− and 265 Q●−/Q2− reactions using adiabatic electron affinities computed with density functional theory and solvation energies computed with three continuum solvation models; IEF-PCM, COSMO, and SM12. Regression analyses indicate a strong linear correlation between experimental and absolute computed Q/Q●− reduction potentials with Pearson's correlation coefficient r between 0.95-0.96 and mean absolute error (MAE) relative to the linear fit between 83.29-89.51 mV for different solvation methods when the slope of the regression is constrained to one. The same analysis for Q●−/Q2− gave a linear regression with r between 0.74-0.90 and MAE between 95.87-144.53 mV, respectively. The y-intercept values obtained from the linear regressions are in good agreement with the range of absolute reduction potentials reported in the literature for the SCE but reveal several sources of systematic error. The y-intercepts from Q●−/Q2− calculations are lower than those of Q/Q●− by around 400 mV for PCM and SM12 and 200 mV for COSMO. Systematic errors also arise between molecules having different ring sizes (benzoquinones, naphthoquinones, and anthraquinones) and different substituents (titratable vs. non-titratable). SCF convergence issues were found to be a source of random error that were slightly reduced by directly optimizing the solute structure in the continuum solvent reaction field. While SM12 MAEs were lower than those of PCM and COSMO for Q/Q●−, SM12 had larger errors for Q●−/Q2− pointing to a limitation when describing multiply charged anions in DMF. Together, the results highlight the advantage of---and further need for---testing computational methods using a large experimental data set that is not skewed (e.g., having more titratable than non-titrable substituents on different parent groups or vice versa) to help further distinguish between sources of random and systematic errors in the calculations.
Efficient Energy Conversion using Tri-nuclear M-Ru(II)-M[M= Pt(II), Re(I)] Catalysts
Authors: Khan Shrabani , Biswas Sanwayee , Das Bishnu , Tabassum Borah Sakira , Lahan Deep , Gupta Parna
Published: May 2024

The tri-nuclear Pt(II)-Ru(II)-Pt(II)(RuPt2) and Re(I)-Ru(II)-Re(II)(RuRe2) complexes, synthesized from mononuclear Ru(II) complex were explored for efficient energy conversion through water splitting and CO2 reduction. The catalysts show excellent activity, serving as promising platforms for sustainable energy applications. The study focuses on designing, stepwise synthesis of the catalysts with insights into the multiple components’ contribution to enhanced catalytic performance. Photophysical and electrochemical analyses highlight the role of the complexes as photocatalysts, where the Ru(II)-polypyridyl unit acts as photosensitizer and the Pt(II)/ Re(I)-polypyridyl units as catalytic sites. Synergistic effects among the components lead to stability, improved performance and emphasizes the significance of multi-nuclear M-Ru(II)-M[M= Pt(II), Re(I)] catalysts in promoting cleaner and more sustainable energy sources.
Constrained Nuclear-Electronic Orbital QM/MM Approach for Simulating Complex Systems with Quantum Nuclear Delocalization Effects Incorporated
Authors: Zhao Xianyuan , Chen Zehua , Yang Yang
Published: May 2024

The hybrid quantum mechanics/molecular mechanics (QM/MM) approach, which combines the accuracy of quantum mechanical (QM) methods with the efficiency of molecular mechanics (MM) methods, is widely used in the study of complex systems. However, past QM/MM implementations often neglect or face challenges in addressing nuclear quantum effects, despite their crucial role in many key chemical and biological processes. Recently, our group developed the constrained nuclear-electronic orbital (CNEO) theory, a cost-efficient approach that accurately addresses nuclear quantum effects, especially quantum nuclear delocalization effects. In this work, we integrate CNEO with QM/MM methods through the electrostatic embedding scheme and apply the resulting CNEO QM/MM to two hydrogen-bonded complexes in both gas and aqueous phases. We find that both solvation effects and nuclear quantum effects significantly impact hydrogen bond structures and dynamics. Notably, in the glutamic acid - glutamate complex, which mimics a low barrier hydrogen bond in human transketolase, CNEO QM/MM accurately predicts nearly equal proton sharing between the two residues, with predicted oxygen-hydrogen distance in excellent agreement with experimental results. With an accurate description of both nuclear quantum effects and environmental effects, CNEO QM/MM is a promising new approach for simulating complex chemical and biological systems.
Materials Challenges for Electric Vehicles
Authors: Li Yiyang , Lukatskaya Maria
Published: May 2024

Electric vehicles provide the ability to substantially reduce or eliminate greenhouse gas emissions from transportation. Such vehicles utilize a fundamentally different powertrain technology compared to conventional vehicles based on the internal combustion of liquid fuels. In this series of articles, we discuss material challenges related to three key subsystems related to the powertrain of electric vehicles: batteries, power electronics, and permanent magnets. Given that electric vehicles currently occupy ~20% of the market share and are projected to rapidly rise, a cross-cutting challenge among these systems is the sustainability and resilience of the global supply chain of critical minerals to enable this adoption of electric vehicles.
Uterine artery embolization in the treatment of uterine fibroids and the preservation of reproductive health in women 40 years of age and older: A retrospective study
Authors: Solovyeva Alina V. , Chegus Larisa  A. , Aleynikova Ekaterina  Yu. , Semenchenko Sergey I. , Menshikh Oksana  I. , Kasparova Anzhelika  E.
Published: May 2024

Aim. To evaluate the effect of uterine artery embolization (UAE) on reproductive health in women 40 years and older.
Materials and methods. A retrospective study was conducted at the perinatal center of the District Clinical Hospital of Khanty-Mansiysk. Patients were divided into two groups: the main group (group 1; n=57) included women with uterine fibroids after UAE, and the control group (group 2; n=42) included women without a history of uterine fibroids.
Results. Women with uterine fibroids were statistically more likely to have grade 1 obesity (χ2=4.39; p=0.04) and less likely to have normal body weight (χ2=8.73; p=0.00) compared to women without fibroids. Smoking increased the risk of uterine fibroids twofold (χ2=4.49; p=0.03; odds ratio 1.97; confidence interval 0.64-6.11). More women with uterine fibroids had a history of abortions (n=42; 73.7%) than those without uterine fibroids (n=19; 45.2%; χ2=8.27; p=0.01). The most common gynecological comorbidities in women with uterine fibroids included inflammatory disease of the uterus (N71), endometrial polyp (N84), and endometriosis (N80); p0.05. The most common extragenital diseases in patients with uterine fibroids included thyroid disease, hypertension, and iron deficiency anemia (p0.05). Contour SE embolization agent with spherical particles was more often associated with pain (χ2=0.18; p=0.67) and less often with fever (χ2=4.47; p=0.03). There was a decrease in the number of short menstrual cycles (less than 24 days) from the moment before surgical treatment and after 24 months (χ2=34.580; p0.001) and an increase in the number of cycles of 24–38 days (χ2=14.887; p=0.005). At 24 months after UAE, there were more women with a menstrual period of less than 3 days (χ2=10.385; p=0.035) and fewer with a menstrual period of more than 8 days (χ2=34.573; p0.001). Ultrasound showed a decreased ovarian reserve at 6, 12 and 24 months after UAE (p0.05).
Conclusion. When assessing the reproductive health of women 40 years and older after embolization of the uterine arteries, it was found that this method of treatment of symptomatic uterine fibroids leads to a decrease in the duration and heaviness of menstruation but increases the risk of an ovarian reserve decrease.
Adherence to endocrine therapy with tamoxifen and satisfaction with follow-up of women with breast cancer by a gynecologist: A survey study
Authors: Golubenko Ekaterina O. , Savelyeva Marina I. , Korennaya Vera V.
Published: May 2024

Background. Side effects of endocrine therapy with tamoxifen (TAM) reduce the quality of life of patients with breast cancer (BC) and adversely affect treatment compliance. Against the background of treatment of BC with TAM, the risk of developing endometrial hyperplasia (EH) increases. At the moment, algorithms for monitoring patients receiving TAM by an obstetrician-gynecologist have not been developed and approved. There are also divergent opinions of experts regarding the diagnosis and management of patients in the detection of EH. This article presents the results of the final stage of the study in 2017–2022 – a survey study. The purpose of this study was to assess adherence to endocrine therapy and satisfaction with observation by a gynecologist of women with BC after 5 years of observation and their relationship with the identified early associated polymorphisms of the CYP2D6, CYP3A5, CYP2C9 and ABCB1 genes.
Materials and methods. 54 patients with BC, out of 120 who had previously passed the first pharmacogenetic stage of the study, were interviewed with specially designed questionnaire. Due to the small sample size, delta percentages (∆%) were used in each comparison group with a difference threshold of 5%. To assess associations with the studied genetic polymorphisms, previously obtained significant associations of adverse drug reactions with pharmacogenetics in the same patients were used.
Results. The prevalence of all adverse drug reactions (ADRs), with the exception of EH, was higher in the group of patients who canceled TAM. Over 5 years of follow-up, 57.4% of patients were regularly observed by an obstetrician-gynecologist, 42.59% of patients visited a gynecologist less than once a year. Of all the respondents, 53.7% of patients are satisfied with the regularity and quality of dispensary observation by an oncologist, 33.33% of patients are satisfied with the regularity and quality of dispensary observation by an obstetrician-gynecologist. All studied ADRs (EH, hot flashes, asthenia, bone pain and dyspepsia) associated with various genetic polymorphisms, prevailed in the group of patients who stopped taking TAM due to drug intolerance (∆%: 25.72, 6.97, 4.81, 6.97 and 24.52 respectively) compared with the TAM-group.
Conclusion. The results obtained confirm the role of the studied genetic polymorphisms in the development of ADRs of TAM, but only systemic (hot flashes, asthenia, bone pain and dyspepsia). With regard to endometrial hyperplasia, no significant differences were obtained, which requires more extensive studies.
Clinical and history features of patients with recurrent deep endometriosis: A retrospective study
Authors: Senina Daria N. , Pashaeva Saadat A. , Kulakova Yuliya A. , Chuprynin Vladimir D. , Asaturova Aleksandra  V. , Ezhova Larisa S. , Buralkina Natalia A.
Published: May 2024

Aim. To identify clinical and history features of patients with recurrent deep endometriosis (RDE).
Materials and methods. A retrospective study of clinical and history data of 200 patients with DE undergoing surgical treatment at the Department of General Surgery of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology in 2020–2021. Group 1 included 80 patients with RDE, group 2 included 120 patients with newly diagnosed DE. All patients underwent surgical treatment followed by immunohistochemical examination and DE confirmation.
Results. An association was found between the young age of the patient at the time of the first surgery and the type of endometriosis. It was found that women with a history of endometriosis surgery in early reproductive years (29.22±5.3 years) are at risk of recurrent endometriosis. Two or more surgeries were reported in 33.7% of RDE patients. In 90.2% of patients, endometriosis recurred with clinical manifestations; in 9.8%, it was asymptomatic and diagnosed on pelvic ultrasound. The group of RDE patients showed a longer period of infertility (5.432±3.53 years) than the group with newly diagnosed DE (2.953±1.29 years). It was found that the surgeries performed in RDE patients were longer, more complex, and associated with more blood loss. Intestinal resection, ureterolysis, adhesiolysis, and salpingectomy were significantly more common in the RDE group than in patients without a history of endometriosis surgery.
Conclusion. In most cases, RDE is clinically manifested, rarely asymptomatic and diagnosed by visualization methods. Patients with a history of surgery at a younger age are at risk of RDE, and their surgical interventions are more complicated with more blood loss. Currently, surgical treatment of DE is the optimal method; however, it has serious disadvantages with severe and even life-threatening postoperative complications.
The use of hyaluronic acid based bulking agent for stress urinary incontinence in women: A prospective controlled study
Authors: Zhevlakova Maria M. , Rusina Elena I. , Shelaeva Elizaveta V. , Yarmolinskaya Maria I.
Published: May 2024

Background. Paraurethral injection of bulking agents in women is one of the minimally invasive technologies for the treatment of stress urinary incontinence (SUI). The effectiveness and safety of this method depend on the properties of injected substance.
Aim. To evaluate the results of paraurethral injections of 1,4-butanediol diglycidyl ether crosslinked high-density hyaluronic acid (EsteFILL® intim) in the treatment of SUI in women of reproductive and perimenopausal age.
Materials and methods. We examined 18 patients aged 45.8±5.0 years with mild SUI in combination with grade I–II genital prolapse. After general clinical and special studies (urination diaries, King and PISQ-12 questionnaires, cough test, complex urodynamic study, urethrovesical segment and pelvic floor ultrasound with compression elastography) paraurethral injection of 4.0 ml EsteFILL® intim drug was performed. The results of therapy were studied 1 and 6 months after the procedure.
Results. It was found that the injection of the drug contributed to an increase in the stiffness of paraurethral tissues by 1.5 times within 6 months after injection. According to the results of elastography before treatment, the average value of the strain ratio of paraurethral tissues of the proximal posterior wall of the urethra was 0.66±0.46 (0.42–0.91), after 1 and 6 months – 0.99±0.45 (0.76–1.23) and 1.00±0.36 (0.78–1.22) respectively; p=0.009 and 0.018. The effectiveness of EsteFILL® intim drug in the treatment of mild SUI in women after 1 and 6 months according to the results of a cough test was 88.2 and 71.4%, according to urination diaries – 88.9 and 66.7% respectively. During the entire observation period the patients noted a decrease in the degree of discomfort due to SUI and an improvement in the quality of life.
Conclusion. Paraurethral injection of EsteFILL® intim drug helps to increase the stiffness of the urethra supporting structures in patients with SUI. This method of treating SUI is effective for women of reproductive and perimenopausal age with mild severity disease, who do not plan surgical treatment, are interested in achieving a quick result of therapy and are informed that the effect decreases over time after the procedure.
Current view of the management of patients with endometrial hyperplasia: A review
Authors: Khachatryan Aznar S. , Dobrokhotova Yulia E. , Il'ina Irina Yu. , Kazantsev Sergey N.
Published: May 2024

Endometrial hyperplasia (EH) is a spectrum of morphological changes in the endometrium characterized by the proliferation of glands and an increase in the gland-stromal ratio. The relevance of this disease is due to its high prevalence (10–55%). The clinical significance of EH is related to the increased risk of endometrioid cancer. One of the leading causes of EH is absolute or relative hyperestrogenism and progesterone deficiency that does not eliminate the proliferative effect of estrogens. The risk group for EH includes women with early menarche, late menopause, infertility, anovulation, polycystic ovary syndrome, obesity, type 2 diabetes mellitus, hypertension, Lynch syndrome, estrogen-producing ovarian tumors, as well as those receiving estrogen monotherapy or tamoxifen. Most leading experts believe that therapy should include surgery followed by drug therapy aimed at eliminating risk factors to reduce the risk of EH recurrence. Despite numerous research findings demonstrating the benefits of a particular treatment modality and the consequent presence of these modalities in clinical guidelines, the potential benefits of alternative therapies are still being discussed. This issue requires further study and the selection of optimal treatment regimens for patients with EH.
GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation
Authors: Baur Katja , Şan Şeydanur , Hölzl-Wenig Gabriele , Mandl Claudia , Hellwig Andrea , Ciccolini Francesca
Published: May 2024

We recently reported that growth/differentiation factor 15 (GDF15) and its receptor GDNF family receptor alpha-like (GFRAL) are expressed in the periventricular germinal epithelium thereby regulating apical progenitor proliferation. However, the mechanisms are unknown. We now found GFRAL in primary cilia and altered cilia morphology upon GDF15 ablation. Mutant progenitors also displayed increased histone deacetylase 6 (Hdac6) and ciliary adenylate cyclase 3 (Adcy3) transcript levels. Consistently, microtubule acetylation, endogenous sonic hedgehog (SHH) activation and ciliary ADCY3 were all affected in this group. Application of exogenous GDF15 or pharmacological antagonists of either HDAC6 or ADCY3 similarly normalized ciliary morphology, proliferation and SHH signalling. Notably,Gdf15ablation affected Hdac6 expression and cilia length only in the mutant periventricular niche, in concomitance with ciliary localization of GFRAL. In contrast, in the hippocampus, where GFRAL was not expressed in the cilium, progenitors displayed altered Adcy3 expression and SHH signalling, but Hdac6 expression, cilia morphology and ciliary ADCY3 levels remained unchanged. Thus, ciliary signalling underlies the effect of GDF15 on primary cilia elongation and proliferation in apical progenitors.
The immune and microbial homeostasis determines theCandida–mast cells cross-talk in celiac disease
Authors: Renga Giorgia , Pariano Marilena , D’Onofrio Fiorella , Pieraccini Giuseppe , Di Serio Claudia , Villella Valeria Rachela , Abbate Carlo , Puccetti Matteo , Giovagnoli Stefano , Stincardini Claudia , Bellet Marina Maria , Ricci Maurizio , Costantini Claudio , Oikonomou Vasileios , Romani Luigina
Published: May 2024

Celiac disease (CD) is an autoimmune enteropathy resulting from an interaction between diet, genome, and immunity. Although many patients respond to a gluten-free diet, in a substantive number of individuals, the intestinal injury persists. Thus, other factors might amplify the ongoing inflammation.Candida albicansis a commensal fungus that is well adapted to the intestinal life. However, specific conditions increaseCandidapathogenicity. The hypothesis thatCandidamay be a trigger in CD has been proposed after the observation of similarity between a fungal wall component and two CD-related gliadin T-cell epitopes. However, despite being implicated in intestinal disorders,Candidamay also protect against immune pathologies highlighting a more intriguing role in the gut. Herein, we postulated that a state of chronic inflammation associated with microbial dysbiosis and leaky gut are favorable conditions that promoteC. albicanspathogenicity eventually contributing to CD pathology via a mast cells (MC)-IL-9 axis. However, the restoration of immune and microbial homeostasis promotes a beneficialC. albicans–MC cross-talk favoring the attenuation of CD pathology to alleviate CD pathology and symptoms.
REMEMProt: a resource of membrane-enriched proteome profiles, their disease associations, and biomarker status
Authors: Aravind Anjana , Nandakumar Revathy , Ahmed Mukhtar , Nisar Mahammad , Palollathil Akhina , Kanichery Anagha , Sreelan Sourav , Sinan KP Munavvar , Balaya Rex Devasahayam Arokia , Vijayakumar Manavalan , Prasad Thottethodi Subrahmanya Keshava , Raju Rajesh
Published: May 2024

The differential expression of plasma membrane proteins is integrally analyzed for their diagnosis, prognosis, and therapeutic applications in diverse clinical manifestations. Necessarily, distinct membrane protein enrichment methods and mass spectrometry platforms are employed for their global and relative quantitation. First of its kind to explore, we compiled membrane-associated proteomes in human and mouse systems into a database named, Resource of Experimental Membrane-Enriched Mass spectrometry–derived Proteome (REMEMProt). It currently hosts 14,626 proteins (9,507 proteins inHomo sapiens; 5,119 proteins inMus musculus) with information on their membrane-protein enrichment methods, experimental/physiological context of detection in cells or tissues, transmembrane domain analysis, and their current attribution as biomarkers. Based on these annotations and the transmembrane domain analysis in proteins or their binary/complex protein–protein interactors, REMEMProt facilitates the assessment of the plasma membrane localization potential of proteins through batch query. A cross-study enrichment analysis platform is enabled in REMEMProt for comparative analysis of proteomes using novel/modified membrane enrichment methods and evaluation of methods for targeted enrichment of membrane proteins. REMEMProt data are made freely accessible to explore and download athttps://rememprot.ciods.in/.
Trim66’s paternal deficiency causes intrauterine overgrowth
Authors: Mielnicka Monika , Tabaro Francesco , Sureka Rahul , Acurzio Basilia , Paoletti Renata , Scavizzi Ferdinando , Raspa Marcello , Crevenna Alvaro H , Lapouge Karine , Remans Kim , Boulard Matthieu
Published: May 2024

The tripartite motif-containing protein 66 (TRIM66, also known as TIF1-delta) is a PHD-Bromo–containing protein primarily expressed in post-meiotic male germ cells known as spermatids. Biophysical assays showed that the TRIM66 PHD-Bromodomain binds to H3 N-terminus only when lysine 4 is unmethylated. We addressed TRIM66’s role in reproduction by loss-of-function genetics in the mouse. Males homozygous forTrim66-nullmutations produced functional spermatozoa. Round spermatids lacking TRIM66 up-regulated a network of genes involved in histone acetylation and H3K4 methylation. Profiling of H3K4me3 patterns in the sperm produced by theTrim66-null mutant showed minor alterations below statistical significance. Unexpectedly,Trim66-null males, but not females, sired pups overweight at birth, hence revealing thatTrim66mutations cause a paternal effect phenotype.
Poder e autoridade feminina na idade média : atas da X Semana de Estudos Medievais
Authors: Brochado Cláudia Costa
Published: May 2024

Os textos reunidos nestas Atas derivam das comunicações apresentados na X Semana de Estudos Medievais (SEM), ocorrida em janeiro de 2022, um evento organizado periodicamente pelo Programa de Estudos Medievais (PEM) da Universidade de Brasília (UnB). Nesta edição, com o tema "Poder e Autoridade Feminina na Idade Média" os debates se concentraram na importante contribuição das mulheres à cultura medieval, considerando a riqueza de suas experiências como místicas, rainhas, abadessas e produtoras de textos ricos e instigantes. As mulheres atuaram nos mais variados campos: medicina, filosofia, ensino, literatura, comércio etc., e os trabalhos que aqui se apresentam são um indicativo das variadas possibilidades de pesquisa, envolvendo a especificidade feminina no mundo medieval, campo de estudos e de conhecimento com muito ainda por desbravar.
Experimental determination of forces arising in process of milling ice from road surfaces
Authors: Troshin D. I. , Shamakhov L. M. , Lysakov N. E. , Goncharenko D. A. , Kamnev D. M.
Published: May 2024

Introduction. To ensure the safety and effective cleaning of highways and sidewalks from snow and ice in winter, it is necessary to use special equipment. But even at the stage of creating such equipment, designers need to know what loads will occur on the working equipment during its operation. Therefore, in order to develop milling working bodies for removing ice from road surfaces, it is necessary to conduct an experimental study in order to determine the loads arising on its working body.

Materials and methods. The main purpose of the experimental study is to determine the cutting resistance force that occurs on the cutting element of milling working equipment during its application when cleaning ice and snow on highways and sidewalks. To implement the experiment, a pendulum stand was selected, which allows to study the effect of a separate cutting element of a milling cutter on ice.

Results. The results obtained make it possible to predict changes in loads on the milling working body during operation. This makes it possible to develop more advanced designs of road milling equipment and modernize existing ones. The use of these dependencies also enables to determine the necessary structural strength of the milling drum for the normal operation of the equipment and to choose a rational section of the cutting elements.

Discussion and conclusions. According to the results of the experimental work carried out, the dependences of the ice cutting resistance depending on the thickness of the cut layer, the type of ice (pure, a mixture of ice, sand and compacted snow with impurities, a mixture of frozen layers, frozen paving slabs and a sample of asphalt concrete) and its temperature were obtained.
Electric discharge process modelling when piston pins recovery in internal combustion engines
Authors: Savenko E. S. , Savenko E. S. , Matvienko S. A. , Kasparyants A. G.
Published: May 2024

Introduction. The relevance of the topic of the presented article is determined by the improvement of the technology for repairing and restoring machine parts. Currently, the technology of restoring piston pins of internal combustion engines (ICE) by a high-energy method of plastic deformation of metal using the energy of a high-voltage pulse discharge in a liquid is widely used – the electrohydraulic effect, and on its basis electrohydraulic processing. The purpose of the article is to increase the efficiency of the method of restoring piston pins of internal combustion engines due to the use of the electrohydraulic distribution method.

Materials and methods. The research methods such as the analysis of the degree of influence of the electrical parameters of the electrohydraulic distribution process on the amount of deformation of the piston fingers depending on the relevant material were used. The article discusses a mathematical model of the electric discharge process when restoring piston pins. The calculation method determines the modes and parameters of the process of electrohydraulic distribution of piston pins while maintaining their fatigue life, static strength and wear resistance.

Results. In this work, the degree of influence of the electrical parameters of the electrohydraulic distribution process on the amount of deformation of the piston pins, depending on the product material used, is established. A mathematical model of the electric discharge process during the restoration of piston pins has been developed, and based on them, the modes and parameters of the process of electrohydraulic distribution of piston pins have been determined while maintaining their fatigue life, static strength and wear resistance.

Discussion and conclusions. The studies have shown that exploding wires made of iron, copper, and tungsten are not effective in restoring piston pins with an internal radius of up to 10 mm. The pressure in the case of their use does not exceed 100 MPa. Exploding Al wires with a diameter of less than one millimeter have the greatest effect. In this case, the inductance of the circuit should be minimal, because this provides the largest share of the energy released in the discharge channel from all stored in the capacitor. This ensures the highest pressure in the channel. Based on the same considerations, the capacity should be limited to a range of 3-12 UF. This method can be applied to the restoration of other car parts.
Boosting Network Security: A comparative Analysis of Deep Learning Techniques for Intrusion Detection
Authors:   Associate Professor, Department of CSE East Point College of Engineering and Technology, Bengaluru, Karnataka, INDIA, Kousar Dr.Heena
Published: May 2024

This paper addresses demanding situations in Intrusion Detection Systems (IDS) by way of combining the Adaptive Synthetic Sampling (ADASYN) method with a break up-primarily based Resnet framework. ADASYN balances sample distribution, overcoming biases in the direction of large samples. Our method extracts multiscale functions, reduces interchannel redundancy, and enhances the version's capability using a smooth hobby operation. We recommend a Residual Neural Network (ResNN) version for intrusion detection, displaying massive enhancements in recognition accuracy and execution performance. Ongoing work targets to optimize performance further, highlighting the capacity for extra strong IDS solutions.
Distributed Ledger Approach BlockChain- Based Integrated EHR: A Ethereum Smart Contract Method
Authors:   Assistant Professor/ Dept of CSE East Point College of Engineering and Technology, Bengaluru, Karnataka, INDIA, K Revathi
Published: May 2024

Blockchain, on the other hand, is a groundbreaking technology that provides a distributed and Decentralized environment in which nodes in a list of networks can connect to each other without the need for a central authority. It has the potential to overcome the limits of Electronic Health Record (EHR) management and create a more secure, Decentralized, and safer environment for exchanging EHR data. Further, blockchain is a distributed ledger on which data can be stored and shared in a cryptographically secure, validated, and mutually agreed-upon manner across all mining nodes. The blockchain stores data with a high level of integrity and robustness, and it cannot be altered. Electronic health records (EHRs) are digitally saved health records that provide information about a person’s health. EHRs are generally shared among healthcare stakeholders, and thus are susceptible to power failures, data misuse, a lack of privacy, security, and an audit trail, among other problems. The aim of our proposed framework is firstly to implement blockchain technology for EHR and secondly to provide secure storage of electronic records by defining granular access rules for the users of the proposed framework. Moreover, this framework also discusses the scalability problem faced by the blockchain technology in general via use of off-chain storage of the records. This framework provides the EHR system with the benefits of having a scalable, secure and integral blockchain-based solution.
Towards a Resilient Industrial Recovery of Ukraine: a Study of Regional Systems in Wartime
Authors: Gibadullin Oleksiy , Dunayev Ihor
Published: May 2024

This article develops an analytical approach to building a system for sustainable industrial recovery and attracting skilled labor to the regional economy even during wartime. The goal of the article is to analytically justify the development vector of the industrial sectors of regions and identify internal reserves, "growth points" of the industrial potential of Ukrainian regions as the basis for regenerative processes during martial law and after combat operations. The author notes that a key element in the process of forming a system for sustainable industrial recovery is the understanding of the presence of internal resources, factors that facilitate their effective use, and the determination of the vector for building the industrial recovery system of regions based on them. This requires a broad scientific view of this extraordinary problem and, consequently, a comprehensive analytical approach. Such an approach would combine both the analysis of the current state of industrial facilities and the determination of the need for personnel and resources for modernization, taking into account both local resources and internal factors, including the length of logistic chains, the presence of demand for products, and technological innovations. Currently, it is possible to observe both the dynamism of regenerative processes and scientific "gaps" in the principles of systems analysis in organizing and managing the recovery of the industry, which would be related to the recovery processes in the industrial sector of Ukraine today. The article reveals "growth points" for revising the system of sustainable industrial recovery during martial law and after Victory as a prerequisite for post-war recovery and sustainable development of regions, which is a basic condition for searching and implementing ways to optimally use available resources, overcoming technological gaps, and creating conditions for the return of skilled migrants to Ukraine.
Understanding Human-Machine Dialogue:Implications for Role Orientation,Trust
relationship, and Interpersonal Communication
Authors: 王 袁欣 , 朱 孟潇 , 陈 思潞
Published: May 2024

机器的主体性正在涌现,从工具性向社交性演进的过程,改变了传统以人类为中心的传播模式。本研究采用深度访谈法,分别对智能语音助手和闲聊式聊天机器人用户进行半结构式访谈。研究从人机对话的形式切入,探讨人机互动关系中智能机器人的角色定位、信任关系以及对人际交往的影响。研究发现机器的拟人化属性是角色奠定的基础,用户对机器的角色定位能够减少互动的不确定性。自我表露行为是建立人机信任关系的催化剂,双方的自我表露有助于模糊人机边界意识,但身体的离席仍是制约其深度发展的藩篱。人机关系看似为摆脱社交恐惧提供一剂解药,并试图替代人际交往,但回归真实的人际交往才有利于规避数字时代的社会化危机。未来人机之间可能会建立一种新型的“混合”关系,甚至重塑人际传播秩序。
Explorando los valores propios de la cooperación al desarrollo municipalista. Propuesta de un marco y análisis del caso del Fons Valencià per la Solidaritat
Authors: Belda-Miquel Sergio , Talón Alba , Cuesta-Delgado Daniel
Published: May 2024

El trabajo busca contribuir al debate sobre las potencialidades de la cooperación al desarrollo municipal con la exploración del caso de los fondos locales de cooperación, apenas abordados en la bibliografía.
Para ello, se propone un marco teórico integral donde se identifican los valores diferenciales de la cooperación local desde una perspectiva municipalista. Desde este marco, se aborda el caso del Fons Valencià per la Solidaritat (FVS) y se explora si está contribuyendo a aprovechar las potencialidades de esta cooperación. Se emplean métodos mixtos y fuentes primarias y secundarias de información: bases de datos institucionales, documentación del FVS, entrevistas y cuestionarios dirigidos a personal del FVS y de entidades socias.
Los resultados ilustran el potencial de los fondos para una cooperación municipalista en términos institucionales, instrumentales y relacionales; también, que estas múltiples potencialidades pueden necesitar tiempo para ser desplegadas, y que se enfrentan a distintos retos y contradicciones a ser explorados con más detalle.
Precipitation patterns and their variability in the southern region of Brazil
Authors: Henrique Alves Lapa Carlos , Campos Claudia Guimarães Camargo , Francisco Leal de Quadro Mario , Petry Rufato Daiana
Published: May 2024

Climate change is a long-term transformation of climate patterns, which can be natural or anthropogenic. Signs of climate change can manifest themselves in different ways: through the occurrence of extreme events, rising ocean levels, melting glaciers, among others. Negative impacts are produced by climate change and are one of humanity's biggest concerns, since its effects reach the entire planet with different consequences. Considering the need for actions aimed at contributing to the process of mitigating climate change, the importance of knowing changes in regional climate patterns is emphasized. This study aims to analyze changes in precipitation patterns over time in the southern region of Brazil, including variability, trends, anomalies, droughts and excess rainfall. Daily precipitation data from 1961 to 2020 were used, collected at 15 meteorological stations in the region. Various statistical analyzes were carried out, such as averages, maximum and minimum values, seasonal and annual anomalies, frequency distribution, Mann-Kendall trend tests and the Normalized Precipitation Index (SPI). The results indicate that climate change trends are positive in terms of increasing rainfall volumes, altering rainfall dispersion patterns (volume). In other words, rainfall is more irregular in terms of distribution throughout the seasons. The big highlight was Florianópolis -SC, which during the summer had the highest volume of rain among the meteorological stations studied.
Pegada Hídrica da Palma Forrageira sob Fertirrigação Nitrogenada no Semiárido Brasileiro
Authors: MATOS RIGOBERTO MOREIRA DE , Neto José Dantas , Queiroz Tadeu Miranda de , Silva Patrícia Ferreira da , Saboya Luciano Marcelo Fallé , Lima Vera Lúcia Antunes de , Santos Bárbara Davis Brito dos
Published: May 2024

A pegada hídrica é importante para estimar o consumo total de água e os impactos ambientais ocasionados durante o processo produtivo de uma cultura agrícola. Assim, objetivou com esta pesquisa determinar a pegada hídrica verde, azul e cinza da palma forrageira sob fertirrigação nitrogenada no semiárido brasileiro. O experimento foi desenvolvido em condições de campo no munícipio de Santa Luzia, estado da Paraíba, Brasil. O delineamento em blocos ao acaso e fatorial 5 x 5, constituído de cinco lâminas de irrigação (25; 50; 75; 100 e 125% da ET0), cinco doses de adubação nitrogenada (0; 150; 300; 450 e 600 kg ha-1 de N) e três repetições. Esse delineamento foi utilizado para três cultivares de palma forrageira (Orelha de Elefante; Baiana e Miúda). Analisou-se a pegada hídrica verde, azul e cinza individualmente para cada cultivar estudada. O aumento na dose de nitrogênio reduziu a pegada hídrica verde, azul e cinza das cultivares de palma forrageira. O acréscimo na lâmina de irrigação diminuiu a pegada hídrica verde e cinza, e aumentou a azul. A cultivar Orelha de Elefante propiciou a menor pegada hídrica verde, azul e cinza. A pegada hídrica é um importante indicador, capaz de monitorar o impacto do consumo de água das culturas irrigadas e adubadas sobre o meio ambiente. A pegada hídrica das cultivares de palma forrageira irrigada e adubada é a menor encontrada na literatura, entre as plantas irrigadas, evidenciando o grande potencial dessa forrageira para regiões com pouca disponibilidade de água, como o semiárido brasileiro.