bluuebunny/crossref_metadata_2025 huggingface dataset:
Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data
Authors: Liu Lin , Xue Yuzhou , Chen Yangmei , Chen Tingqiao , Zhong Judan , Shao Xinyi , Chen Jin
Published: March 2023

Background

Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies.

Methods

We performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive–compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne (N = 615,396) and collected summary statistics from the largest available GWAS for depression (N = 500,199), anxiety (N = 17,310), schizophrenia (N = 130,644), OCD (N = 9,725), bipolar disorder (N = 413,466), and PTSD (N = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests.

Results

There was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, p = 0.874], anxiety (OR: 0.961, p = 0.49), OCD (OR: 0.979, p = 0.741), bipolar disorder (OR: 0.972, p = 0.261), and PTSD (OR: 1.054, p = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; p = 0.033).

Conclusion

The increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented.
Mass spectrometry and machine learning in the identification of COVID-19 biomarkers
Authors: Lazari Lucas C. , Santos de Oliveira Gilberto , Macedo-Da-Silva Janaina , Rosa-Fernandes Livia , Palmisano Giuseppe
Published: March 2023

Identifying specific diagnostic and prognostic biological markers of COVID-19 can improve disease surveillance and therapeutic opportunities. Mass spectrometry combined with machine and deep learning techniques has been used to identify pathways that could be targeted therapeutically. Moreover, circulating biomarkers have been identified to detect individuals infected with SARS-CoV-2 and at high risk of hospitalization. In this review, we have surveyed studies that have combined mass spectrometry-based omics techniques (proteomics, lipdomics, and metabolomics) and machine learning/deep learning to understand COVID-19 pathogenesis. After a literature search, we show 42 studies that applied reproducible, accurate, and sensitive mass spectrometry-based analytical techniques and machine/deep learning methods for COVID-19 biomarker discovery and validation. We also demonstrate that multiomics data results in classification models with higher performance. Furthermore, we focus on the combination of MALDI-TOF Mass Spectrometry and machine learning as a diagnostic and prognostic tool already present in the clinics. Finally, we reiterate that despite advances in this field, more optimization in the analytical and computational parts, such as sample preparation, data acquisition, and data analysis, will improve biomarkers that can be used to obtain more accurate diagnostic and prognostic tools.
Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens
Authors: Torres-Ortiz Daniela , García-Alcocer Guadalupe , Loske Achim M. , Fernández Francisco , Becerra-Becerra Edgardo , Esparza Rodrigo , Gonzalez-Reyna Marlen Alexis , Estevez Miriam
Published: March 2023

In this study, green chemistry was used as a tool to obtain gold nanoparticles using Amphipterygium adstringens extracts as a synthesis medium. Green ethanolic and aqueous extracts were obtained using ultrasound and shock wave-assisted extraction. Gold nanoparticles with sizes ranging between 100 and 150 nm were obtained with ultrasound aqueous extract. Interestingly, homogeneous quasi-spherical gold nanoparticles with sizes between 50 and 100 nm were achieved with shock wave aqueous-ethanolic extracts. Furthermore, 10 nm gold nanoparticles were obtained by the traditional methanolic macerate extraction method. The physicochemical characteristics, morphology, size, stability, and Z potential of the nanoparticles were determined using microscopic and spectroscopic techniques. The viability assay in leukemia cells (Jurkat) was performed using two different sets of gold nanoparticles, with final IC50 values of 87 µM and 94.7 µM, reaching a maximum cell viability decrease of 80% The results do not indicate a significant difference between the cytotoxic effects produced by the gold nanoparticles synthesized in this study and vincristine on normal lymphoblasts (CRL-1991).
Replacement, Reduction, and Refinement of Animal Experiments in Anticancer Drug Development: The Contribution of 3D In Vitro Cancer Models in the Drug Efficacy Assessment
Authors: Tosca Elena M. , Ronchi Davide , Facciolo Daniele , Magni Paolo
Published: March 2023

In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold standards in the preclinical assessment of anticancer drug efficacy. 3D in vitro cancer models can be generated through a multitude of techniques, from both immortalized cancer cell lines and primary patient-derived tumor tissue. Among them, spheroids and organoids represent the most versatile and promising models, as they faithfully recapitulate the complexity and heterogeneity of human cancers. Although their recent applications include drug screening programs and personalized medicine, 3D in vitro cancer models have not yet been established as preclinical tools for studying anticancer drug efficacy and supporting preclinical-to-clinical translation, which remains mainly based on animal experimentation. In this review, we describe the state-of-the-art of 3D in vitro cancer models for the efficacy evaluation of anticancer agents, focusing on their potential contribution to replace, reduce and refine animal experimentations, highlighting their strength and weakness, and discussing possible perspectives to overcome current challenges.
The NF-κB Transcriptional Network Is a High-Dose Vitamin C-Targetable Vulnerability in Breast Cancer
Authors: Mussa Ali , Afolabi Hafeez Abiola , Syed Nazmul Huda , Talib Mustafa , Murtadha Ahmad Hafiz , Hajissa Khalid , Mokhtar Noor Fatmawati , Mohamud Rohimah , Hassan Rosline
Published: March 2023

Breast cancer (BC) is the most common cancer type among women with a distinct clinical presentation, but the survival rate remains moderate despite advances in multimodal therapy. Consequently, a deeper understanding of the molecular etiology is required for the development of more effective treatments for BC. The relationship between inflammation and tumorigenesis is well established, and the activation of the pro-inflammatory transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is frequently identified in BC. Constitutive NF-κB activation is linked to cell survival, metastasis, proliferation, and hormonal, chemo-, and radiotherapy resistance. Moreover, the crosstalk between NF-κB and other transcription factors is well documented. It is reported that vitamin C plays a key role in preventing and treating a number of pathological conditions, including cancer, when administered at remarkably high doses. Indeed, vitamin C can regulate the activation of NF-κB by inhibiting specific NF-κB-dependent genes and multiple stimuli. In this review, we examine the various NF-κB impacts on BC development. We also provide some insight into how the NF-κB network may be targeted as a potential vulnerability by using natural pro-oxidant therapies such as vitamin C.
The Restorative Integral Support (RIS) Model: Community-Based Integration of Trauma-Informed Approaches to Advance Equity and Resilience for Boys and Men of Color
Authors: Duncan Stephanie , Horton Heather , Smith Richard , Purnell Bruce , Good Lisa , Larkin Heather
Published: March 2023

Mental health and health promotion research and practice have consistently revealed the social and structural inequities that boys and men of color (BMoC) face. Moreover, scholarship highlights the importance of gender, especially the concepts of masculinity and manhood, in understanding inequities that are experienced. Providers and community leaders are finding culturally relevant ways to foster healing and restoration while addressing racial trauma and the adverse community environments tied to adverse childhood experiences (ACEs). This article introduces the restorative integral support (RIS) model to promote connectivity through networks and to acknowledge the contextual differences BMoC experience when suffering from trauma and adversities. RIS is a framework used to address adversities and trauma while increasing societal awareness and advancing equity. This community-based, multidimensional approach is offered to enhance individual, agency, community, and policymaking leadership, raising awareness of mental health concerns and trauma while offering a flexible guide to developing safe spaces and support for recovery from ACEs and trauma. This article offers an in-depth appreciation of the real-life contexts within which BMoC overcome histories of adversity and trauma, demonstrating how the RIS model is applied to advance structural transformation while fostering community resilience.
A Bibliometric Analysis of Physical Literacy Studies in Relation to Health of Children and Adolescents
Authors: Urbano-Mairena Javier , Castillo-Paredes Antonio , Muñoz-Bermejo Laura , Denche-Zamorano Ángel , Rojo-Ramos Jorge , Pastor-Cisneros Raquel , Mendoza-Muñoz María
Published: March 2023

Regular physical activity (PA) is an essential component of maintaining good health, thereby improving the physical and psychological well-being of the population. PA performed during childhood and adolescence can have repercussions in adulthood, contributing to the prevention of chronic activities and improving quality of life. Given its high relationship with PA, physical literacy could play a crucial role in valuing and participating in a physically active lifestyle, thus addressing low rates of PA participation from an early age. This bibliometric analysis provides a globalized view of physical literacy (PL) and its relationship with health, pathologies, prevention, or intervention among children and adolescents. Publications registered on Web of Science were analyzed using bibliometrics based on data from 141 documents published between 2014 and 2022, while the VOSviewer software v. 1.6.18. was used for the processing and visualization of the data and metadata. The results show an exponential growth in scientific research over the last 8 years, with an accumulation of documents in four journals and a distribution of publications spanning thirty-seven countries and regions. The network of researchers consists of 500 researchers, with the largest number of publications corresponding to 18 co-authors with at least 5 publications. The principal purpose of this research was to identify the most prolific co-authors, most-cited journals and co-authors, and the most relevant keywords.
Estimation of Distances within Real and Virtual Dental Models as a Function of Task Complexity
Authors: Makaremi Masrour , Ristor Rafael , de Brondeau François , Choquart Agathe , Mengelle Camille , N’Kaoua Bernard
Published: March 2023

Orthodontists have seen their practices evolve from estimating distances on plaster models to estimating distances on non-immersive virtual models. However, if the estimation of distance using real models can generate errors (compared to the real distance measured using tools), which remains acceptable from a clinical point of view, is this also the case for distance estimation performed on digital models? To answer this question, 50 orthodontists (31 women and 19 men) with an average age of 36 years (σ = 12.84; min = 23; max = 63) participated in an experiment consisting of estimating 3 types of distances (mandibular crowding, inter-canine distance, and inter-molar distance) on 6 dental models, including 3 real and 3 virtual models. Moreover, these models were of three different levels of complexity (easy, medium, and difficult). The results showed that, overall, the distances were overestimated (compared to the distance measured using an instrument) regardless of the situation (estimates on real or virtual models), but this overestimation was greater for the virtual models than for the real models. In addition, the mental load associated with the estimation tasks was considered by practitioners to be greater for the estimation tasks performed virtually compared to the same tasks performed on plaster models. Finally, when the estimation task was more complex, the number of estimation errors decreased in both the real and virtual situations, which could be related to the greater number of therapeutic issues associated with more complex models.
Whole Sequencing and Detailed Analysis of SARS-CoV-2 Genomes in Southeast Spain: Identification of Recurrent Mutations in the 20E (EU1) Variant with Some Clinical Implications
Authors: López-Andreo María José , Vicente-Romero María Rosario , Bernal Enrique , Navarro-González Inmaculada , Salazar-Martínez Francisco , Cánovas-Cánovas Vanesa , Gil-Ortuño Cristina , Riquelme-Rocamora María Gema , Solano Francisco , Ibáñez-López Francisco Javier , Tomás Cristina , Candel-Pérez Carmen , Pérez-Parra Santiago , Flores-Flores César
Published: March 2023

During the COVID-19 pandemic caused by SARS-CoV-2, new waves have been associated with new variants and have the potential to escape vaccinations. Therefore, it is useful to conduct retrospective genomic surveillance research. Herein, we present a detailed analysis of 88 SARS-CoV-2 genomes belonging to samples taken from COVID-19 patients from October 2020 to April 2021 at the “Reina Sofía” Hospital (Murcia, Spain) focused to variant appeared later. The results at the mentioned stage show the turning point since the 20E (EU1) variant was still prevalent (71.6%), but Alpha was bursting to 14.8%. Concern mutations have been found in 5 genomes classified as 20E (EU1), which were not characteristic of this still little evolved variant. Most of those mutations are found in the spike protein, namely Δ69–70, E484K, Q675H and P681H. However, a relevant deletion in ORF1a at positions 3675–3677 was also identified. These mutations have been reported in many later SARS-CoV-2 lineages, including Omicron. Taken together, our data suggest that preferential emergence mutations could already be present in the early converging evolution. Aside from this, the molecular information has been contrasted with clinical data. Statistical analyses suggest that the correlation between age and severity criteria is significantly higher in the viral samples with more accumulated changes.
The Impact of COVID-19 on Financial Markets and the Real Economy
Authors: Gherghina Ștefan
Published: March 2023

The emergence of the novel coronavirus in December 2019 manifested in an expanding prevalence of confirmed cases worldwide, posing a significant challenge to international healthcare safety; with this incident, the notion of “regular life” shifted (Guven et al [...]
Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients
Authors: Czempik Piotr F. , Wiórek Agnieszka
Published: March 2023

Both iron deficiency (ID) and iron overload can have negative effects on the risk and course of infection. Therefore, the ability to accurately assess iron status in these patients is of the utmost importance. Systemic inflammation in sepsis patients affects the results of standard iron biomarkers and makes accurate diagnosis of ID problematic. The aim of our study was to analyze the association between widely available standard iron biomarkers and selected new iron biomarkers in various iron status subgroups among sepsis patients. Consecutive patients diagnosed with sepsis or septic shock and procalcitonin concentration > 0.5 ng/mL were enrolled. The following iron biomarkers were determined: iron, ferritin, transferrin, transferrin saturation, reticulocyte (Ret) number and percentage, Ret hemoglobin equivalent, Ret fluorescence subpopulations, and hepcidin concentration. The study group comprised 90 study subjects. There were 42 (47%) patients with normal iron status, 6 (6%) with ID without anemia, and 42 (47%) with ID anemia. No meaningful correlation exists between standard and new iron biomarkers in various iron status subgroups among sepsis patients. Therefore, standard iron biomarkers cannot be used to diagnose ID in this cohort.
Prevalence, Attitudes, and Factors Influencing Uptake of the COVID-19 Vaccine in Saudi Arabia
Authors: Felemban Ohood , Al-Zahrani Ahlam , Alsharari Abdalkarem
Published: March 2023

Background: The availability and access to COVID-19 vaccinations are critical to a successful pandemic response. More than 70% of the population reportedly needs to be vaccinated against COVID-19 to achieve herd immunity worldwide. However, the reluctance to get vaccinated with the COVID-19 vaccines is holding up the process of vaccination and efforts to control the pandemic and its negative consequences for the global health system, society, and economy. Previous studies have shown low uptake of vaccination in some Middle Eastern countries due to negative attitudes toward vaccination, including concerns about safety and efficacy and doubts about the need for vaccination. Aim: The aim of this study is to investigate the prevalence, attitudes, and factors influencing COVID-19 vaccine acceptance among healthcare workers, academic staff, and students in Saudi Arabia after the vaccine was made widely available by the government. Method: A cross-sectional survey was conducted to determine the prevalence, attitudes, and association between demographic factors and uptake of the first or second dose of vaccination among Saudi Arabian health workers and students. Data were collected using an online questionnaire administered and distributed through the Qualtrics platform. Results: The study recruited 173 participants from different countries and from different Saudi regions, most of whom were faculty members (n = 83). Results indicated significant differences between regions; the mean attitude score for the Western region (M 3.23) was significantly higher than that for other regions (M 3.08, p = 0.030). There was also an association between education level and number of vaccine doses received. Thus, the participants with higher education were the most compliant with national vaccination requirements (p = 0.004). Although the three professional groups reported social media as the most frequently reported source of information (p = 0.021), administrators were more likely to receive information from the MOH than other professional groups. Similarly, faculty members were more likely to receive information from colleagues and professional journals than the other two professional groups. Conclusions: Government officials should build public confidence through vaccination campaigns and devise effective health education programs to increase vaccination uptake. Authorized institutions can effectively use social media platforms to encourage vaccination and promote awareness among all audiences.
Online Survey of Consumer Preferences for Poinsettia Cultivars
Authors: Posadas Benedict C. , Coker Christine E. H. , Jackson Caitlin , Knight Patricia R. , DelPrince James M. , Langlois Scott A. , Ryals Jenny B.
Published: March 2023

New introductions necessitate ongoing studies to keep producers updated about current trends. Consumer preference study results for poinsettia cultivars may interest breeders, wholesale producers, and retail consumers. An online consumer preference survey, conducted from 15 December 2020 to 19 January 2021, was posted in the Qualtrics software platform. Email distribution lists and Facebook were both used to promote the online survey. The survey link was accompanied by a description introducing the project’s purpose and expressing gratitude for participation. Qualtrics automatically collected participants’ data. The survey was closed, and the data were collected on 19 January 2021 from 792 respondents. This study aimed to identify consumer preferences for traditional red, white, or pink poinsettia cultivars and novelty selections. The topmost preferred poinsettia cultivars are “Princettia Queen Pink”, “Winter Rose Dark Red”, “Ice Punch”, “Christmas Mouse”, “Princettia Pure White”, and “Princettia Hot Pink”. The color of poinsettia cultivars did not significantly affect the respondents’ willingness to pay. However, pot size substantially impacted their willingness to pay for poinsettias. Respondents were willing to pay USD 4.89, 8.13, 12.11, and 17.14 per pot for the 4-, 6-, 8-, and 10-inch potted poinsettias, respectively. Some of the socioeconomic characteristics of the respondents influenced their decisions on how much they were willing to pay for poinsettias.
Dependency of Crystal Violet Dye Removal Behaviors onto Mesoporous V2O5-g-C3N4 Constructed by Simplistic Ultrasonic Method
Authors: Ben Aissa Mohamed Ali , Modwi Abueliz , Albadri Abuzar E. A. E. , Saleh Sayed M.
Published: March 2023

This research examined the production of a V2O5-g-C3N4 nanocomposite to remove organic dyes from wastewater. To generate the V2O5-g-C3N4 nanocomposite, the sonication method was applied. The testing of V2O5-g-C3N4 with various dyes (basic fuchsin (BF), malachite green (MG), crystal violet (CV), Congo red (CR), and methyl orange (MO)) revealed that the nanocomposite has a high adsorption ability towards BF, MG, CV, and CR dyes in comparison with MO dye. It was established that the modification of pH influenced the removal of CV by the V2O5-g-C3N4 nanocomposite and that under optimal operating conditions, efficiency of 664.65 mg g−1 could be attained. The best models for CV adsorption onto the V2O5-g-C3N4 nanocomposite were found to be those based on pseudo-second-order adsorption kinetics and the Langmuir isotherm. According to the FTIR analysis results, the CV adsorption mechanism was connected to π–π interactions and the hydrogen bond.
Limited versus Radical Resection in Mitral Valve Infective Endocarditis Surgery
Authors: Haidari Zaki , Wendt Daniel , Thielmann Matthias , Jakob Heinz , Ruhparwar Arjang , El-Gabry Mohamed
Published: March 2023

Background: Mitral valve repair is preferred in patients undergoing surgical treatment for infective endocarditis (IE) of the native mitral valve, however, radical resection of infected tissue and patch-plasty might potentially lead to low or non-durable repair. We aimed to compare a limited-resection and non-patch technique with the classic radical-resection technique. Methods: Eligible candidates were patients with definitive IE of the native mitral valve undergoing surgery between January 2013 and December 2018. Patients were classified according to the surgical strategy into two groups: limited- versus radical-resection strategy. Propensity score matching was used. Endpoints were repair rate, all-cause mortality (30-day and 2-year), re-endocarditis and reoperation at q-year follow-up. Results: After propensity score matching, 90 patients were included. Follow-up was 100% complete. Mitral valve repair rate was 84% in the limited-resection versus 18% in the radical-resection strategy, p < 0.001. The 30-day and 2-year mortality were 20% versus 13% (p = 0.396) and 33% versus 27% (p = 0.490) in the limited-resection versus radical-resection strategy, respectively. The incidence of re-endocarditis during the 2-year follow-up was 4% in the limited-resection strategy versus 9% in the radical-resection strategy, p = 0.677. Three patients in the limited-resection strategy underwent reoperation of the mitral valve, while there were none in the radical-resection strategy (p = 0.242). Conclusions: Although mortality in patients with IE of the native mitral valve remains high, the limited-resection and non-patch surgical strategy is associated with a significantly higher repair rates with comparable 30-day and mid-term mortality, risk of re-endocarditis and re-operation compared to the radical-resection strategy.
Sex-Based Difference in Aortic Dissection Outcomes: A Multicenter Study
Authors: Nappi Francesco , Petiot Sandra , Salsano Antonio , Avtaar Singh Sanjeet Singh , Berger Joelle , Kostantinou Marisa , Bonnet Severine , Gambardella Ivancarmine , Biancari Fausto , Almazil Almothana , Santini Francesco , Chaara Rim , Fiore Antonio
Published: March 2023

Background: Type A Acute Aortic Dissection (TAAAD) repair is a surgical emergency associated with high morbidity and mortality. Registry data have noted several sex-specific differences in presentation with TAAAD which may account for the differences in men and women undergoing surgery for this condition. Methods: A retrospective review of data from three departments of cardiac surgery (Centre Cardiologique du Nord, Henri-Mondor University Hospital, San Martino University Hospital, Genoa) between January 2005 and 31 December 2021 was conducted. Confounders were adjusted using doubly robust regression models, a combination of regression models with inverse probability treatment weighting by propensity score. Results: 633 patients were included in the study, of which 192 (30.3%) were women. Women were significantly older with reduced haemoglobin levels and pre-operative estimated glomerular filtration rate compared to men. Male patients were more likely to undergo aortic root replacement and partial or total arch repair. Operative mortality (OR 0.745, 95% CI: 0.491–1.130) and early postoperative neurological complication results were comparable between the groups. The adjusted survival curves using IPTW by propensity score confirmed the absence of a significant impact of gender on long-term survival (HR 0.883, 95% CI 0.561–1.198). In a subgroup analysis of women, preoperative levels of arterial lactate (OR 1.468, 95% CI: 1.133–1.901) and mesenteric ischemia after surgery (OR 32.742, 95% CI: 3.361–319.017) were significantly associated with increased operative mortality. Conclusions: The advancing age of female patients alongside raised preoperative level of arterial lactate may account for the increasing preponderance among surgeons to perform more conservative surgery compared to their younger male counterparts although postoperative survival was similar between the groups.
Electro-Mechanical Alterations in Atrial Fibrillation: Structural, Electrical, and Functional Correlates
Authors: Pozios Iraklis , Vouliotis Apostolos Ilias , Dilaveris Polychronis , Tsioufis Constantinos
Published: March 2023

Atrial fibrillation is the most common arrhythmia encountered in clinical practice affecting both patients’ survival and well-being. Apart from aging, many cardiovascular risk factors may cause structural remodeling of the atrial myocardium leading to atrial fibrillation development. Structural remodelling refers to the development of atrial fibrosis, as well as to alterations in atrial size and cellular ultrastructure. The latter includes myolysis, the development of glycogen accumulation, altered Connexin expression, subcellular changes, and sinus rhythm alterations. The structural remodeling of the atrial myocardium is commonly associated with the presence of interatrial block. On the other hand, prolongation of the interatrial conduction time is encountered when atrial pressure is acutely increased. Electrical correlates of conduction disturbances include alterations in P wave parameters, such as partial or advanced interatrial block, alterations in P wave axis, voltage, area, morphology, or abnormal electrophysiological characteristics, such as alterations in bipolar or unipolar voltage mapping, electrogram fractionation, endo-epicardial asynchrony of the atrial wall, or slower cardiac conduction velocity. Functional correlates of conduction disturbances may incorporate alterations in left atrial diameter, volume, or strain. Echocardiography or cardiac magnetic resonance imaging (MRI) is commonly used to assess these parameters. Finally, the echocardiography-derived total atrial conduction time (PA-TDI duration) may reflect both atrial electrical and structural alterations.
Long-Term Renal Function after Catheter Ablation of Atrial Fibrillation
Authors: Kovačević Vladan , Marinković Milan M. , Kocijančić Aleksandar , Isailović Nikola , Simić Jelena , Mihajlović Miroslav , Vučićević Vera , Potpara Tatjana S. , Mujović Nebojša M.
Published: March 2023

Background: Atrial fibrillation (AF) is associated with the development and progression of chronic kidney disease (CKD). This study evaluated the impact of long-term rhythm outcome after catheter ablation (CA) of AF on renal function. Methods and results: The study group included 169 consecutive patients (the mean age was 59.6 ± 10.1 years, 61.5% were males) who underwent their first CA of AF. Renal function was assessed by eGFR (using the CKD-EPI and MDRD formulas), and by creatinine clearance (using the Cockcroft–Gault formula) in each patient before and 5 years after index CA procedure. During the 5-year follow-up after CA, the late recurrence of atrial arrhythmia (LRAA) was documented in 62 patients (36.7%). The mean eGFR, regardless of which formula was used, significantly decreased at 5 years following CA in patients with LRAA (all p < 0.05). In the arrhythmia-free patients, the mean eGFR at 5 years post-CA remained stable (for the CKD-EPI formula: 78.7 ± 17.3 vs. 79.4 ± 17.4, p = 0.555) or even significantly improved (for the MDRD formula: 74.1 ± 17.0 vs. 77.4 ± 19.6, p = 0.029) compared with the baseline. In the multivariable analysis, the independent risk factors for rapid CKD progression (decline in eGFR > 5 mL/min/1.73 m2 per year) were the post-ablation LRAA occurrence (hazard ratio 3.36 [95% CI: 1.25–9.06], p = 0.016), female sex (3.05 [1.13–8.20], p = 0.027), vitamin K antagonists (3.32 [1.28–8.58], p = 0.013), or mineralocorticoid receptor antagonists’ use (3.28 [1.13–9.54], p = 0.029) after CA. Conclusions: LRAA after CA is associated with a significant decrease in eGFR, and it is an independent risk factor for rapid CKD progression. Conversely, eGFR in arrhythmia-free patients after CA remained stable or even improved significantly.
Microplastics Detected in Sediments and Rocks Substrate of Marine Areas with Ghost Nets
Authors: Vitale Dyana , Spinelli Andrea , Picó Yolanda
Published: March 2023

According to UNEP and FAO reports, the fishing nets abandoned in the seas around the world represent approximately 10% of the plastic waste present in the oceans. These nets, also called ghost nets, can be degraded over time, releasing microplastics and contaminating the environment. Studying the presence and amount of microplastics in an area impacted by ghost nets in the Gulf of Cefalù, northern coast of Sicily, Italy can help to understand the level of contamination in these zones. The planned study methodology has been carried out by sampling sediment and rock substrate, on a quantitative basis, by scuba diving at seven stations selected as the most representative for the presence or absence of fishing nets in the study area. Two different extraction methods for sediment and rock samples were taken from the literature and modified for the present study. Microplastics determination was carried out according to, first, a visual identification and, second, a polymer type identification by ATR-FTIR spectroscopy, demonstrating the presence of polyamide, nylon, or polyethylene in the impacted areas, probably derived from the degradation of fishing nets. The present study reports the first record of microplastics determination in rock substrate samples recollected by scuba diving activities.
Speed and Fuel Ratio Optimization for a Dual-Fuel Ship to Minimize Its Carbon Emissions and Cost
Authors: Shih You-Chen , Tzeng Yu-An , Cheng Chih-Wen , Huang Chien-Hua
Published: March 2023

In this study, nondominated sorting genetic algorithm II (NSGA-II) was used to minimize the cost and carbon emissions of a liquefied natural gas (LNG) dual-fuel ship for a given route. This study considered the regulations of emission control areas (ECA) and the European Union (EU) Emissions Trading System (ETS) to determine the optimal speed and LNG/oil ratio for the ship. NSGA-II used the arrival time at each port and the LNG usage ratio for each voyage leg as its genes. The time window for arrival, the fuel cost, and potential EU carbon emission regulations were used to estimate the cost of the considered voyage. Moreover, fuel consumption was determined using historical data that were divided by period, machinery, and voyage leg. The results indicated that the optimal speed and fuel ratio could be determined under any given fuel and carbon price profile by using NSGA-II. Finally, the effects of regulations and carbon price differences on the optimal speed and fuel ratio were investigated. The cost minimization solution was susceptible to being affected by the regulations of ECAs and the EU ETS. The speed profile of the cost minimization solution was found to have a tendency to travel at faster-than-average speeds outside ECAs and non-EU regions, and travel slower in ECAs and EU regions. Meanwhile, the selection of fuel type showed that 100% traditional fuel oil in all regions, but with sufficiently high EU carbon permit cost, tends to use 100% LNG in EU regions.
Photogrammetry, from the Land to the Sea and Beyond: A Unifying Approach to Study Terrestrial and Marine Environments
Authors: Pulido Mantas Torcuato , Roveta Camilla , Calcinai Barbara , di Camillo Cristina Gioia , Gambardella Chiara , Gregorin Chiara , Coppari Martina , Marrocco Teo , Puce Stefania , Riccardi Agnese , Cerrano Carlo
Published: March 2023

The series of technological advances that occurred over the past two decades allowed photogrammetry-based approaches to achieve their actual potential, giving birth to one of the most popular and applied procedures: structure from motion (SfM). The technique expanded rapidly to different environments, from the early ground-based and aerial applications in terrestrial scenarios, to underground and underwater surveys. Nevertheless, the transfer through different media required a period of adaptation that could take anything from years to decades. Only recently, thanks to the emergence of low-cost versatile imaging systems, have airborne and underwater photogrammetry became approachable to a wide range of research budgets, resulting in a popular cost-effective solution for many disciplines. Although numerous review efforts have already been made to resume the current knowledge on photogrammetry, this review summarizes the evolution of the technique in both terrestrial and underwater environments, paying special attention to the transfer of methods and techniques between the two environments. The acquired information helped to identify trends during its development and to highlight the urgency to widen the range of its applications in aquatic habitats in order to fill the current gap of knowledge on their structure and species distribution, delaying the design of proper conservation strategies.
Offshore Fish Farms: A Review of Standards and Guidelines for Design and Analysis
Authors: Chu Yun-Il , Wang Chien-Ming , Zhang Hong , Abdussamie Nagi , Karampour Hassan , Jeng Dong-Sheng , Baumeister Joerg , Aland Per Arild
Published: March 2023

While moving fish farms to offshore sites can be a more sustainable way to expand farmed fish production, the fish pens have to contend with a harsher environment. Thus, it is necessary to draw on offshore engineering competences for designing and analysing the offshore fish farming infrastructure. This paper reviews existing design and analysis guidance from maritime classification and national/international authorities that can be applicable for offshore fish farms. Based on the existing design guidelines, a review of design criteria for offshore fish farms under the following subtopics is provided: design life, design environmental loads, combining environmental loads, and miscellaneous load conditions. This review on the global performance analysis procedures and methods is presented based on practices used for neighbouring industries, such as offshore oil and gas and wind energy production, under the following subtopics: hydrostatic analysis, hydrodynamic analysis, and mooring system analysis with introducing theoretical background and modelling techniques. This paper also highlights limitations and cautions when using these design and analysis methods. Providing this comprehensive information, as well as commentary on their applications, will help engineers and designers to develop offshore fish farming infrastructure with confidence.
Influence of Different Static Equilibrium Calculation Methods on the Dynamic Response of Marine Cables during the Releasing Process: Review and a Case Study
Authors: Zhang Dapeng , Zhao Bowen , Sun Jiyuan , Zhang Yi , Zhu Keqiang , Jiang Haoyu
Published: March 2023

When analyzing the dynamic characteristics of marine cables, the static equilibrium state must first be calculated; a dynamic analysis can then be carried out based on the static equilibrium. Since the calculation of the static equilibrium is the basis of dynamic calculation, different methods for the calculation of the static equilibrium will have important impacts on the dynamic response characteristics of cables, which result in cables having different dynamic characteristics. This paper summarizes the research progress in the effects of different methods for the calculation of the static equilibrium on the dynamic response of marine cables during the releasing process, and current methods for their static calculation are more comprehensively developed as well as being more accurate. To study the influence of different static equilibrium calculation methods, with the reference of some specific parameters of a mooring cable, combined with specific sea conditions, through the necessary simplification of the cable releasing process, based on the lumped mass method, mooring cables are discretized into the lumped mass model, and dynamic analysis models of the releasing process of mooring cables under three methods for the calculation of the static equilibriums (the fast static equilibrium calculation method, the analytic catenary calculation method, and the catenary calculation method) are established. The dynamic characteristics of the spatial configurations of mooring cables based on different static equilibrium calculation methods are obtained through time domain coupling analyses. It was found that if the static equilibrium of a cable is calculated, taking into account gravity, buoyancy, wave current resistance, inertia forces, and the axial stiffness of a cable, then the characteristics of a cable during dynamic descent are closest to that of a real situation. The calculation results have a certain guiding significance for specific engineering practices.
The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?
Authors: Alvarez-Moreno Carlos A. , Morales-López Soraya , Rodriguez Gerson J. , Rodriguez Jose Y. , Robert Estelle , Picot Carine , Ceballos-Garzon Andrés , Parra-Giraldo Claudia M. , Le Pape Patrice
Published: March 2023

Candida auris has become a major health threat due to its transmissibility, multidrug resistance and severe outcomes. In a case-control design, 74 hospitalised patients with candidemia were enrolled. In total, 22 cases (29.7%) and 52 controls (C. albicans, 21.6%; C. parapsilosis, 21.6%; C. tropicalis, 21.6%; C. glabrata, 1.4%) were included and analysed in this study. Risk factors, clinical and microbiological characteristics and outcomes of patients with C. auris and non-auris Candida species (NACS) candidemia were compared. Previous fluconazole exposure was significantly higher in C. auris candidemia patients (OR 3.3; 1.15–9.5). Most C. auris isolates were resistant to fluconazole (86.3%) and amphotericin B (59%) whilst NACS isolates were generally susceptible. No isolates resistant to echinocandins were detected. The average time to start antifungal therapy was 3.6 days. Sixty-three (85.1%) patients received adequate antifungal therapy, without significant differences between the two groups. The crude mortality at 30 and 90 days of candidemia was up to 37.8% and 40.5%, respectively. However, there was no difference in mortality both at 30 and 90 days between the group with candidemia by C. auris (31.8%) and by NACS (42.3%) (OR 0.6; 95% IC 0.24–1.97) and 36.4% and 42.3% (0.77; 0.27–2.1), respectively. In this study, mortality due to candidemia between C. auris and NACS was similar. Appropriate antifungal therapy in both groups may have contributed to finding no differences in outcomes.
Impact of Proof of Work (PoW)-Based Blockchain Applications on the Environment: A Systematic Review and Research Agenda
Authors: Sapra Nishant , Shaikh Imlak , Dash Ashutosh
Published: March 2023

Blockchain technology is being looked at to solve numerous real-world problems that demand transparency by meeting sustainable goals. Do we ponder whether this technology is a boon or a bane for the environment? This paper analyses blockchain’s dominant consensus method, Proof-of-Work (PoW), which consumes more energy than Malaysia and Sweden and further deteriorates the environment through carbon emissions. This study is the first systematic evaluation of PoW consensus-based blockchain applications’ environmental consequences. We found 11 significant Theories, 6 Contexts, and 26 Methodologies (TCM) in 60 reviewed articles. We propose an Antecedents, Drivers, and Outcomes (ADO) model, which depicts that marginal profits drive high energy consumption and carbon emissions, with non-renewable energy proportionally responsible for carbon emissions. The article distinctively uses an integrated TCM-ADO framework for literature synthesis and the PESTLE framework for reporting future research areas. This is the first study to use the following four frameworks: PRISMA; TCM; ADO; and PESTLE for systematic literature review. Profit is identified as one of the most significant drivers of energy consumption and further carbon emissions. The article proposes 65 future research areas and makes theoretical contributions to the literature that may interest academicians, practitioners, and social stakeholders.
Living in a Chinese Industrial New Town: A Case Study of Chenglingji New Port Area
Authors: Shen Yao , Zhang Xu , Zhu Hongfei , Yin Zicheng , Drianda Riela Provi
Published: March 2023

Building new industrial towns has become a popular strategy for the Chinese government, as part of its aim to disperse the population and create new concentrations of activity. However, relevant studies have shown that these development strategies often struggle to provide appropriate infrastructure and public services to residents. In this paper, we explore the case of Chenglingji new port area, which is an industrial new town in Yueyang City, Hunan Province. To understand the provision of public services in the area, we analyzed the construction of public service facilities using GIS software, while 939 questionnaires were distributed and collected from local residents and workers. The survey results confirm the low level of satisfaction with the livability of the area, and the lack and unevenness of public services to meet the needs of local residents and foreign workers. It further emphasizes that the provision of public services should be considered in the future planning of the Chenglingji new port area. We also provide some suggestions on the construction of industrial new towns of the same type as Chenglingji and other developing countries.
Park Recreation Intention and Satisfaction of Blue-Collar Workers Based on the ACSI Model: A Case Study of Anning Industrial Park in Yunnan
Authors: Xie Xiaohuan , Li Yinrong , Wang Ruobing , Gou Zhonghua
Published: March 2023

The negative effects of long working hours and shift work on the physical and mental health of blue-collar groups should not be underestimated. Under intense stress, they have limited time to access recreational green space, and their own health is thus affected. In this study, a conceptual model of recreational satisfaction among blue-collar workers was established based on the American Customer Satisfaction Index (ACSI). The model explores the factors affecting their level of satisfaction when using recreational spaces. Anning Industrial Park in Yunnan Province was used as an example. User data were collected and analyzed using a questionnaire survey and structural equation methods. The results indicate that recreation intention, perceived park quality characteristics, and perceived value all had significant and positive effects on the park recreation satisfaction of blue-collar workers. This study applied social economics theory to the field of landscape planning, identified the typical characteristics of blue-collar workers and their green space use, and strived to optimize the UGS configuration and functional facilities through the evaluation of recreation satisfaction indexes, which provided guidance and reference for improving the service quality of green spaces.
Distributional and Acoustic Characteristics of Filler Particles in German with Consideration of Forensic-Phonetic Aspects
Authors: Muhlack Beeke , Trouvain Jürgen , Jessen Michael
Published: March 2023

In this study, we investigate the use of the filler particles (FPs) uh, um, hm, as well as glottal FPs and tongue clicks of 100 male native German speakers in a corpus of spontaneous speech. For this purpose, the frequency distribution, FP duration, duration of pauses surrounding FPs, voice quality of FPs, and their vowel quality are investigated in two conditions, namely, normal speech and Lombard speech. Speaker-specific patterns are investigated on the basis of twelve sample speakers. Our results show that tongue clicks and glottal FPs are as common as typically described FPs, and should be a part of disfluency research. Moreover, the frequency of uh, um, and hm decreases in the Lombard condition while the opposite is found for tongue clicks. Furthermore, along with the usual F1 increase, a considerable reduction in vowel space is found in the Lombard condition for the vowels in uh and um. A high degree of within- and between-speaker variation is found on the individual speaker level.
Solving the Vehicle Routing Problem for a Reverse Logistics Hybrid Fleet Considering Real-Time Road Conditions
Authors: Li Mengke , Shi Yongkui , Li Meiyan
Published: March 2023

In this study, a bi-objective optimization model was established to solve the cooperative distribution problem of a multi-center hybrid fleet by integrating reverse logistics under real-time road conditions. According to the characteristics of the problem and considering the power level and battery capacity of electric vehicles, the multi-objective immune genetic algorithm (MOIGA) was designed and compared with an elitist strategy genetic algorithm, i.e., the fast non-dominated sorting genetic algorithm (NSGA-II). The scale of the MOIGA solution set exceeded that of the NSGA-II, which proved that the global search ability of MOIGA was better than that of the NSGA-II. The operating efficiency of the MOIGA was lower than that of the NSGA-II, but it could also find the optimal solution within an acceptable time range. This method can reduce the total cost of operating a hybrid fleet and can meet the needs of customers, and therefore, improve customer satisfaction.