bluuebunny/crossref_metadata_2025 huggingface dataset:
Nitric Oxide Synthesis Inhibition Does Not Impair Water Immersion-Induced Renal Vasodilation in Humans
Authors: DIJKHORST-OEI LIOE-TING , BOER PETER , RABELINK TON J. , KOOMANS HEIN A.
Published: April 2021

Nitric oxide (NO) is tonically released in the kidney to maintain renal perfusion and adequate sodium and water clearance. Little is known about the role of NO in the renal adaptation to an acute volume challenge. This is important for our understanding of pathophysiologic conditions associated with impaired NO activity. This study examined the effects of NO synthesis inhibition on neurohumoral, renal hemodynamic, and excretory responses to head-out immersion (HOI). Seven healthy men underwent four 7-h clearance studies. One study served as a time control study (placebo infusion), and in one study N
G-monomethyl-L-arginine (L-NMMA; 3 mg/kg priming dose + 3 mg/kg per h) was infused during hours 2 to 5. In a third and fourth clearance study, HOI was applied from hours 3 to 5, during infusion of either placebo or L-NMMA. To assess the degree of NO synthesis inhibition, the effect of L-NMMA on [15N]-arginine-to-[15N]-citrulline conversion rate was studied in four others. HOI decreased mean arterial pressure (MAP) from 87 ± 3 to 76 ± 2 mmHg and renal vascular resistance (RVR) from 82 ± 6 to 70 ± 7 mmHg · min/L, and increased sodium excretion (UNaV) from 110 ± 27 to 195 ± 29 μmol/min and flow (UV) from 14.4 ± 1.4 to 15.8 ± 1.4 ml/min. L-NMMA caused profound and sustained increases in MAP and RVR and decreases in UNaV and UV. HOI superimposed on L-NMMA infusion decreased the elevated MAP from 93 ± 4 to 83 ± 2 mmHg and RVR from 111 ± 9 to 95 ± 7 mmHg · min/L, and increased UNaV from 41 ± 8 to 95 ± 15 μmol/min and UV from 10.0 ± 1.1 to 12.7 ± 1.4 ml/min. The relative changes were not significantly different from the effects of HOI without L-NMMA infusion. HOI decreased plasma renin activity and aldosterone and increased plasma atrial natriuretic peptide and urinary cGMP. L-NMMA decreased urinary cGMP, but did not affect the plasma hormones or the changes induced by HOI. L-NMMA decreased the [15N]-arginine-to-[15N]-citrulline conversion rate to one-third of baseline. The results indicate that in a state of NO deficiency in humans, the kidney can still respond to an acute volume challenge with vasorelaxation, diuresis, and natriuresis.
Minimizing Hemodialysis Vascular Access Trauma with an Improved Needle Design
Authors: ROSS EDWARD A. , VERLANDER JILL W. , KOO LILIA C. , HAWKINS IRVIN F.
Published: April 2021

The maintenance and longevity of hemodialysis vascular access remains one of the most problematic topics in the care of dialysis patients. Although much attention has focused on neointimal hyperplasia, the repetitive trauma to vessel walls by dialysis needles causes significant cumulative damage that has undergone little investigation. Commercial needles have beveled tips with intentional cutting surfaces to ease insertion. It was hypothesized that a pencil-point conical-shaped needle would cause less damage by taking advantage of the elasticity of native fistulae and produce an improved hole configuration in synthetic materials with minimal ability to stretch. A needle was subsequently designed with a removable pencil-point trocar and a side arm for the dialysis tubing. Once the trocar is removed, the blunt-ended cannula can be advanced or can be subject to inadvertent motion without causing damage to the luminal surface of the access. The new design as well as standard 15-gauge hemodialysis needles were tested on Gore-Tex® graft material and two bovine carotid artery preparations. Scanning electron microscopy was used to study the hole patterns. For all materials, the commercial needle holes had typical crescent shapes, and the cuts sliced sequentially through the various layers. For grafts, the new design caused a linear defect parallel to the axis of the graft that may preserve longitudinal strength. Interestingly, that tear line was nearly perpendicular to the linear hole in the thin polytetrafluoroethylene overwrap, which would be consistent with maintenance of hoop integrity. It is believed that these nonoverlapping defects would also improve hemostasis. The bovine specimens tested the importance of tissue stretching: Fresh carotid artery had experimental holes dramatically smaller than those from standard needles. In the denatured tissue, the experimental needle provided less benefit than that observed in fresh tissue, which is likely due to limited elasticity of the preserved artery. Improvement in needle design thus provides distinct advantages for native vessels and unique less traumatic holes in current synthetic materials. Pencil-point needle designs may be particularly applicable to the development of new elastomeric graft material.
From Tonus to Tonicity
Authors: WALDEGGER SIEGFRIED , JENTSCH THOMAS J.
Published: April 2021

Chloride channels are involved in a multitude of physiologic processes ranging from basal cellular functions such as cell volume regulation and acidification of intracellular vesicles to more specialized mechanisms such as vectorial transepithelial transport and regulation of cellular excitability. This plethora of functions is accomplished by numerous functionally highly diverse chloride channels that are only partially identified at the molecular level. The CLC family of chloride channels comprises at present nine members in mammals that differ with respect to biophysical properties, cellular compartmentalization, and tissue distribution. Their common structural features include a predicted topology model with 10 to 12 transmembrane regions together with two C-terminal CBS domains. Loss of function mutations affecting three different members of the CLC channel family lead to three human inherited diseases: myotonia congenita, Dent's disease, and Bartter's syndrome. These diseases, together with the diabetes insipidus symptoms of a knockout mouse model, emphasize the physiologic relevance of this ion channel family.
Effects of Low Dose Sympathetic Inhibition on Glomerulosclerosis and Albuminuria in Subtotally Nephrectomized Rats
Authors: AMANN KERSTIN , RUMP LARS CHRISTIAN , SIMONAVICIENE AURELIA , OBERHAUSER VITUS , WESSELS SABINE , ORTH STEPHAN R. , GROSS MARIE-LUISE , KOCH ANDREAS , BIELENBERG GERHARD W. , VAN KATS JORGE P. , EHMKE HEIMO , MALL GERHARD , RITZ EBERHARD
Published: April 2021

A potential role of the sympathetic nervous system in progression of renal failure has received little attention. This study examined whether nonhypotensive doses of moxonidine, an agent that reduces sympathetic activity, affects glomerulosclerosis, urine albumin excretion, and indices of renal handling of norepinephrine (NE) in subtotally nephrectomized (SNX) rats. Sprague Dawley rats were SNX or sham-operated (control). SNX rats were either left untreated or treated with moxonidine in a dose (1.5 mg/kg body wt per d) that did not modify telemetrically monitored 24-h BP. Glomerular and renal morphology were evaluated by quantitative histology, immunohistochemistry, and in situ hybridization. Urine albumin excretion rate was analyzed by enzyme-linked immunosorbent assay, and kidney angiotensin II and NE content were measured using HPLC, 3H-NE uptake, and release. Body and kidney weight and BP were not significantly different between SNX with or without moxonidine. The glomerulosclerosis index was significantly lower in moxonidine-treated (0.88 ± 0.09) compared with untreated (1.55 ± 0.28) SNX rats, as was the index of vascular damage (0.32 ± 0.14 versus 0.67 ± 0.16). The number of proliferating cell nuclear antigen-positive glomerular and tubular cells per area was significantly higher in untreated SNX rats than in controls and moxonidine-treated SNX rats. The same was true for urine albumin excretion rate. Renal angiotensin II tissue concentration was not affected by moxonidine. In untreated SNX rats, renal nerve stimulation and exogenous NE induced an increase in isolated kidney perfusion pressure (102 ± 21 versus 63 ± 8 mmHg). Renal endogenous NE content was significantly lower in SNX rats than in controls (86 ± 14 versus 140 ± 17 pg/mg wet weight). Cortical uptake of [3H]-NE was not different, but cortical NE release was significantly higher in SNX rats than in controls. Reduced function of presynaptic inhibitory α-adreno-receptors is unlikely because an α2-adrenoceptor antagonist increased NE release. At subantihypertensive doses, moxonidine ameliorates renal structural and functional damage in SNX animals, possibly through central inhibition of efferent sympathetic nerve traffic. In kidneys of SNX rats, indirect evidence was found for increased activity of a reduced number of nerve fibers.
Dyadic Relationship Conflict, Gender, and Mortality in Urban Hemodialysis Patients
Authors: KIMMEL PAUL L. , PETERSON ROLF A. , WEIHS KAREN L. , SHIDLER NICOLE , SIMMENS SAMUEL J. , ALLEYNE SYLVAN , CRUZ ILLUMINADO , YANOVSKI JACK A. , VEIS JUDITH H. , PHILLIPS TERRY M.
Published: April 2021

The effects of dyadic satisfaction and conflict have not been well defined in the hemodialysis (HD) population. The aim of this study was to determine whether the perception of decreased dyadic satisfaction was associated with mortality in patients treated with HD, and if so, whether there were different relationships between risk factors, and differential outcomes in men and women. A total of 174 HD patients, primarily African-Americans, involved in dyadic relationships for more than 6 mo had indices of dyadic satisfaction, depression, perception of illness effects, social support, behavioral compliance with the dialysis prescription, and plasma interleukin-1 (IL-1) and β-endorphin levels measured. Cox proportional hazards models assessed relative mortality risks. Patients' dyadic satisfaction scores correlated with β-endorphin levels. There was no correlation of IL-1 or β-endorphin with any psychosocial or behavioral compliance measure in the group as a whole. Correlations between psychosocial, medical, and neuroimmunologic variables were different in men and women. For women, dyadic satisfaction correlated with β-endorphin levels, depression, and perception of illness. Women with higher dyadic satisfaction and decreased dyadic conflict were at decreased mortality risk, but dyadic adjustment indices were unassociated with differential survival in the larger group of men. Correlations between neuroendocrine and immune markers are different in African-American male and female HD patients. Greater dyadic satisfaction and lower dyadic conflict are independently associated with decreased mortality in female African-American HD patients, of the same order of magnitude as medical risk factors. Such effects may be attributable to a relationship between dyadic satisfaction and conflict and health-related behaviors, or through an effect on neuroendocrine or immunologic status.
Karaciğer fonksiyon testleri bozukluğu göstergesi olarak Manyetik Rezonans Kolanjiyopankreatografide minimal perihepatik sıvı varlığı
Authors: ÖZ Diğdem , PEKER Elif , CAN İlknur , ERDEN Gül , ERDEN İlhan
Published: April 2021

Giriş ve Amaç: Karaciğer ve karaciğer dışı patolojilere bağlı görüntülemede perihepatik alanda sıvı görülebilmektedir. Belirli bir patolojiye spesifik olmayan bu durum değişik mekanizmalar ile oluşabilmektedir. Bu çalışmanın amacı manyetik rezonans kolanjiyopankreatografide minimal perihepatik sıvı varlığı ile karaciğer fonksiyon testleri ve manyetik rezonans kolanjiyopankreatografide ortaya koyulabilecek etiyolojik faktörlerden olan biliyer obstrüksiyon ile arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Hastanemiz Radyoloji bölümünde 2017 yılında manyetik rezonans kolanjiyopankreatografi yapılan hastalar retrospektif olarak tarandı. Minimal perihepatik sıvısı olan 62 hasta çalışma grubuna, perihepatik sıvısı olmayan ve rastgele seçilen 62 hasta kontrol grubuna dahil edildi. Hasta ve kontrol grubuna ait karaciğer fonksiyon testleri (aspartat aminotransferaz, alanin aminotransferaz, alkalen fosfataz, gama-glutamil transpeptidaz, laktat dehidrogenaz, total/direkt/indirekt bilirübin) karşılaştırıldı. Perihepatik sıvı kalınlığı, dağılım paterni, karaciğer loblarına göre lokalizasyonu, intrahepatik safra kanallarında genişleme varlığı ve derecesi, koledok taşı, periportal ödem, perisplenik sıvı varlığı kaydedildi ve perihepatik sıvı ile arasındaki ilişki değerlendirildi. Bulgular: Perihepatik sıvısı olan hasta grubunda laktat dehidrogenaz dışında tüm laboratuvar değerleri kontrol grubuna göre anlamlı olarak yüksekti (p = 0.131 ve p ≤ 0.011, sırasıyla) ve perihepatik sıvısı olan grupta kontrol grubuna göre daha fazla hastada laboratuvar değerlerinde yükseklik saptandı (p ≤ 0.037). İntrahepatik safra kanallarında genişleme ve perisplenik sıvı varlığı açısından iki grup arasındaki fark istatistiksel olarak anlamlı idi (p = 0.01 ve p < 0.001, sırasıyla). Alkalen fosfataz değerleri ile intrahepatik safra kanalları genişleme derecesi korelasyon göstermekteydi (r = 0.349, p = 0.05). Sonuç: Manyetik rezonans kolanjiyopankreatografide karaciğer çevresinde minimal düzeyde sıvı varlığı karaciğer fonksiyon testlerinde bozukluğa işaret edebilir ve kolestaza neden olabilecek patolojiler açısından uyarıcı olmalıdır.
Mide hiperplastik polipleri ve öncül lezyonlarının değerlendirilmesi
Authors: PEKSÖZ Rıfat , MIZRAK Ali
Published: April 2021

Giriş ve Amaç: Mide poliplerinin yaklaşık %75-90 kadarını hiperplastik polipler oluşturur. Kronik inflamasyon nedenli epitelin aşırı rejenerasyonuna bağlı, foveolar hiperplazi ve kronik gastrit sonrasında bu öncül lezyonlardan hiperplastik polipler oluşur. Bu çalışmada mide hiperplastik polipler ve öncül lezyonlarının Helicobacter pylori ile ilişkisi ve bu lezyonların intestinal metaplazi, atrofi durumlarının literatür bilgileri eşliğinde tartışılması amaçlanmıştır. Gereç ve Yöntem: Muş Devlet Hastanesi Endoskopi ünitesinde Ocak 2016-Ocak 2020 tarihleri arasında özofagogastroduodenoskopi yapılan 7903 hastadan endoskopik görünümü polipoid yapıda olan 172 hastanın histopatolojileri değerlendirildi. Hastaların yaşı, cinsiyeti, başvuru şikâyeti, polipoid görünümlü lezyonun yeri, lezyonların histopatolojik tipi kaydedildi. Bulgular: 172 hastaya polipektomi yapıldı. Hastaların 71’i erkek (%41.2), 101’i kadın (%58.8) olup, yaş ortalamaları 49.4 ± 15 (19-83) yıldı. Hastalar reaktif polipoid lezyonlar; foveolar hiperplazi 57 hasta, kronik gastrit 53 hasta ve gerçek polipoid 62 hasta (en sık hiperplastik polip 47 hasta %75) olarak iki gruba ayrıldı. Polipoid görünümlü lezyonlar en fazla antrumda lokalize idi. Hastaların başvuru şikayeti her iki grupta en fazla dispepsi idi. Gerçek polip lezyonlarının çapı, reaktif polipoid lezyonların çapından istatistiksel olarak büyük saptandı (p < 0.05). Helicobacter pylori oranı reaktif polipoid grupta istatistiksel olarak daha yüksek bulundu (p < 0.05). İntestinal metaplazi ve atrofi durumu açısından fark saptanmadı (p > 0.05). Sonuç: Hiperplastik polipler ve öncül lezyonlarının prekanseröz durumlar olan atrofi ve intestinal metaplazi oranları arasında anlamlı fark saptanmamıştır. Bu yüzden endoskopide saptanan lezyonlardan tanı ve displazinin varlığını saptamak için biyopsi alınmalı ya da eksize edilmeli ve Helicobacter pylori saptanan hastalar tedavi edilmelidir.
Autism Spectrum Disorder Behavioral Implications of the Covid-19 Process, and Individuals’ Awareness and Reactions to Pandemic Conditions based on California, USA
Authors: Choi Myung Suh , Chon Irene , Lee Katherine , Kang Kevin , Kim Juno , Bae Eddie
Published: April 2021

Vulnerable populations, such as patients with mental illnesses, are known to be overly influenced during disasters and pandemics. However, little is known about how people with autism spectrum disorder (ASD), one of the most common neurodevelopmental conditions in the world with a prevalence of 1%, are affected by health-related disasters, particularly the current Covid-19 pandemic. We investigated how individuals with ASD responded to Covid-19 in terms of comprehension and adherence to implemented measures; changes in their behavioral problems; and how the anxiety levels of their caregivers relate to these behavioral changes. Our sample consisted of 50 individuals with ASD (30 male and 20 female; ages ranged from 3 to 14). The majority of our participants had trouble grasping what Covid-19 is and the measurements it necessitates. They also encountered difficulties in implementing pandemic-related social distance and hygiene regulations. During this time, the majority of students stopped receiving special education. In terms of increased stereo-types, aggression, hypersensitivity, behavioral problems, and sleep and appetite changes, we observed a Covid-19-related clinical presentation that resembled PTSD in individuals with ASD. Aberrant Behavior Checklist (ABC) subscales differed significantly before and after the pandemic conditions. There were differences among the caregivers’ anxiety levels between the current behavioral problem levels to the behavioral problem levels prior to the pandemic. The difference in ABC total score, and specifically the lethargy/social withdrawal subscale score, predicted the anxiety score of the parents. Our findings suggest that the Covid-19 period poses unique challenges for people with ASD and their caregivers, emphasizing the importance of targeted, distance special education interventions and other support services for this population.
Comparison of two methods for prolong storage of decellularized mouse whole testis for tissue engineering application: An experimental study
Authors: Majidi Gharenaz Nasrin , Movahedin Mansoureh , Mazaheri Zohreh
Published: April 2021

Background: Biological scaffolds are derived by the decellularization of tissues or organs. Various biological scaffolds, such as scaffolds for the liver, lung, esophagus, dermis, and human testicles, have been produced. Their application in tissue engineering has created the need for cryopreservation processes to store these scaffolds.
Objective: The aim was to compare the two methods for prolong storage testicular scaffolds.
Materials and Methods: In this experimental study, 20 male NMRI mice (8 wk) were sacrificed and their testes were removed and treated with 0.5% sodium dodecyl sulfate followed by Triton X-100 0.5%. The efficiency of decellularization was determined by histology and DNA quantification. Testicular scaffolds were stored in phosphate-buffered saline solution at 4ºC or cryopreserved by programmed slow freezing followed by storage in liquid nitrogen. Masson’s trichrome staining, Alcian blue staining and immunohistochemistry, collagen assay, and glycosaminoglycan assay were done prior to and after six months of storage under each condition.
Results: Hematoxylin-eosin staining showed no remnant cells after the completion of decellularization. DNA content analysis indicated that approximately 98% of the DNA was removed from the tissue (p = 0.02). Histological evaluation confirmed the preservation of extracellular matrix components in the fresh and frozen-thawed scaffolds. Extracellular matrix components were decreased by 4ºC-stored scaffolds. Cytotoxicity tests with mouse embryonic fibroblast showed that the scaffolds were biocompatible and did not have a harmful effect on the proliferation of mouse embryonic fibroblast cells.
Conclusion: Our results demonstrated the superiority of the slow freezing method for prolong storage of testicular scaffolds.
Key words: Cryopreservation, Testis, Scaffold, Mouse.
Role of hyaluronic acid intrauterine injection in the prevention of Asherman’s syndrome in women undergoing uterine septum resection: An RCT
Authors: Zahra Ghanadzadeh Tafti Seiede , Javaheri Atiye , Dehghani Firoozabadi Razieh , Kabirpour Ashkezar Samane , Falahzadeh Abarghouei Hossein
Published: April 2021

Background: Adhesion due to intrauterine surgery such as septal resection associated with damaged endometrium can increase the risk of Asherman’s syndrome. The main goal of treatment in this syndrome is to repair the damaged endometrium for creating a physiological pregnancy.
Objective: To investigate the effect of intrauterine injection of hyaluronic acid on the prevention of Asherman’s syndrome in women undergoing uterine septum resection.
Materials and Methods: In this double-blind randomized clinical trial, 65 women undergoing the uterine septum resection were divided into two groups; the case group (n = 34) and the control group (n = 31). Immediately after the septal resection with a resectoscope, 1cc of hyaluronic acid gel in the case group and 1cc normal saline solution as a placebo in the control group was injected into the uterine cavity. After two months, existence of intrauterine adhesions in the both groups was examined by the hysteroscope and assessment of menstrual patterns, according to the American Society for Reproductive Medicine criteria.
Results: Our results showed that after intervention, the incidence of Asherman’s syndrome in the control group was higher than the case group (p = 0.012). In the case group, only four women had poor adhesion (Asherman’s syndrome) at the end of the study, while the rest of them were free of any adhesions in the uterine cavity. In the control group, however, only 19 were free of intrauterine adhesions and 12 had mild symptoms.
Conclusion: The results of the study exhibited the hyaluronic acid capacity to reduce the risk of Asherman’s syndrome in women with endometrial damage following a septal resection surgery.
Key words: Asherman’s syndrome, Septum, Uterine, Hyaluronic acid, Resection.
Corrigendum to “Comparison of conventional IVF versus ICSI in non-male factor, normoresponder patients” [Iran J Reprod Med 2012; 10: 131-136]
Authors: Eftekhar Maryam , Mohammadian Farnaz , Yousefnejad Fariba , Molaei Behnaz , Aflatoonian Abbas
Published: April 2021

This article is a corrigendum to "Comparison of conventional IVF versus ICSI in non-male factor, normoresponder patients” [Iran J Reprod Med 2012; 10: 131–136]. Please download the PDF or view the article HTML.
The Effect of Different Filling Materials Used on Immature Maxillary Central Teeth with Different Apical Diameters on Fracture Resistance
Authors: AYRANCİ Leyla , ÇETİNKAYA Ahmet , ÖZDOĞAN Alper , ÖZKAN Serkan
Published: April 2021

Objective: This study aims to investigate the effect of different treatment options on immature maxillary central teeth simulated with two different apical diameters on fracture resistance.Methods: Forty-eight maxillary central teeth with a singular root canal were collected for this in-vitro study. The specimens were decoronated to 17±0,12 mm long for ensuring standardization. All samples were randomly divided into two groups: 1,2mm group (G1) prepared with No. 4 Peaso Reamer and 1.8mm group (G2) prepared with No. 6 Peaso Reamer. Each parent group is divided into 4 subgroups (n=6) to form treatment groups. The positive control group was prepared without the access cavity to simulate the immature tooth (P) and negative control (N) group was prepared and filled calcium hydroxide. In group 3 MTA was condensed with a hand plugger to obtain a 3mm thick apical plug and remaining parts of the canals were filled with Guttaflow Bioseal cold filling system (G). In group 4, simulated immature roots were filled completely MTA (M). All samples were kept at 37° C and % 100 humidity for four weeks. Fracture test was performed by applying a load at an angle 135 degrees to the long axis of the teeth until a fracture occured using a universal test device.Results: There was a statistically significant interaction between apical enlargement diameter and fill type on fracture resistance (p<0,05). The fracture resistances of the negative control groups in both of group 1 and group 2 were significantly different from those of the other groups (p<0,05). There was no statistically significant difference in fracture resistance according to filling type in 1,2mm apical diameter groups (p>0,05). GuttaFlow (G) group in the 1,8mm apical diameter group has the highest fracture resistance while the MTA (M) group has the closest fracture resistance to the negative control group.Conclusion: Despite the restrictions in our study, the backfilling with GuttaFlow Bioseal in large apical diameter teeth may be beneficial in terms of fracture resistance.
Recurrent Herpes Zoster as a Sign of HIV Infection
Authors: ETGÜ Fatma
Published: April 2021

Herpes Zoster is characterized with painful dermatomal blisters, which commonly seen in elderly or immuncompromised people. It is caused by varicella zoster virüs (VZV). HIV infection is known as a risk factor for herpes zoster and for developments of its complications. Cutaneous findings can be the presenting symptom for HIV infection. In the presence of HIV infection, HZ can be prolong or can complicate evet its recurrence rate increases. HZ recurrences are usually seen in immuncompromised individuals. In the presence of HIV infection, the risk of HZ increases up to 12-17 fold. Prophylaxis with daily asiclovir decrease the risk of HZ by 68%. Vaccination for HZ was found safe and effective in HIV patients with CD4+ cell count more than 200 cells/. Skin findings are frequent in HIV patients and its diversity change according to the stages of the disease. Here we report a case of recurrent HZ which later diagnosed with positive for HIV, therefore, to mention HIV as a risk factor in cases of recurrent HZ.
Health Benefits of Cornelian Cherry (Cornus mas L.)
Authors: KAYA Zeliha , KOCA İlkay
Published: April 2021

Medicinal plants have been used for medical objectives since ancient times due to their beneficial properties, and their uses continue to this day. The Cornelian cherry fruit (Cornus mas L.) is considered to be one of those medicinal plants with important nutritional and therapeutic properties. It has been also used for different medical purposes in many countries in Europe and Asia for centuries due to its various important components in terms of health. Cornelian cherry is known to have antimicrobial, antioxidant, anticancer and anti-inflammatory effects due to its composition of phenolic compounds and ursolic acid. It is reported in the literature that This fruit is used in different countries for different purposes; for the treatment of intestinal and kidney diseases, strengthening immunity, and preventing some types of cancer and others. It is also used in traditional medicine to cure fever, cholera, kidney stones, malaria, urinary tract infections, heat stroke and bleeding. Many studies have reported the positive effect of Cornelian cherry in regulating blood sugar and preventing fat accumulation in the liver. Similar to many countries, it is grown in Turkey in many regions and it is consumed processed or fresh into several crops such as compote, jam, marmalade and fruit leather. This paper has reviewed the investigative studies of the health effect of cornelian cherry.
Pleomorphic Adenoma: Report of Two Cases with an Unusual Presentation
Authors: AKÇAY ÇELİK Mürüvvet
Published: April 2021

Pleomorphic adenoma is the most common salivary gland tumor. Pleomorphic adenoma also known as benign mixed tumor. Most commonly affected site is the parotid gland. It may also occur in other major salivary glands (submandibular and sublingual glands), lacrimal glands and minor salivary glands. Pleomorphic adenoma arises as a painless, firm swelling, slowly growing in the oral cavity. Pleomorphic adenoma is a benign triphasic salivary gland tumor that occurs in epithelial, myoepithelial, and chondromyxoid stroma. Complete surgical resection with negative margins is the main treatment method in Pleomorphic adenoma, insufficient resection for treatment causes local recurrence.It is an entity that should be considered in oral cavity lesions. Here, cases of Pleomorphic adenoma with maxillary localization are mentioned.
Definition of the total antioxidant capacity and vitamin D levels in professional athletes who play football in Giresunspor
Authors: BAHAR İrem , CEBİ Aysegul
Published: April 2021

Objective: A sufficient amount of vitamin D levels; while protein synthesis, muscle strength, jumping height, speed, exercise capacity, and physical performance increase; stress fractures cause a decrease in the rates of injury, fall, muscle relaxation, muscle pain, and weakness. Serum 25-hydroxy vitamin D (25(OH)D) levels are very important for maintaining and improving optimal performance in football players. The formation of free radicals and oxidative stress during exercise is known to affect optimal performance and recovery period after exercise. The aim of the study was to determine serum 25(OH)D and total antioxidant capacity of professional football players. Methods: The study group consists of 56 professional football players (26 players from the first team, 30 players from the academy team) playing in Giresunspor Football Club. The control group consisted of 30 volunteer healthy male subjects. The SPSS 21 package program was used to calculate and interpret the survey data applied face to face to the study group. In addition, the body composition of the players was determined by the InBody 230 device which works with the principle of bioelectric impedance analysis (BIA). Serum 25(OH)D levels of the football players were compared with reference values (≥30 ng / mL). Serum 25(OH)D levels were determined by immunoassay method on the Roche Cobas e411 branded test analyzer. Serum total antioxidant capacity was compared with 30 healthy volunteers in the control group. Total antioxidant capacity measurements were studied with the ready-to-use kit. The method previously described for the kit has been applied to Architect c8000 clinical chemistry autoanalyzer.Results: As a result of the study, mean serum 25(OH)D levels of the players were determined as 31.68 ng / mL. The mean serum antioxidant capacity of the participants was found to be 1.97 mmol Trolox Equiv/L. The mean serum antioxidant capacity of the control group was 1.94 mmol Trolox Equiv/L.Conclusion: Mean serum 25(OH)D levels of the players were within the reference range (≥30 ng/mL).There is an increase in metabolic rate during training, which leads to a rapid release of free radicals. Despite this thought, there was no significant difference in serum total antioxidant capacity between the study and control groups.
The Effect Of COVID-19 Pandemic on The Anxiety Levels of Radiology Experts And Clinical Functioning
Authors: ALTAŞ Hilal , BOSTAN Sedat
Published: April 2021

Objective: The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a novel human corona virus rapidly spread all over the world and caused Corona Virus Disease-2019 (COVID-19) pandemic. Radiology clinics were reorganised according to the changes in health system in order to combat with this epidemic. We aimed to detect the changes in the functioning of radiology clinics and to state anxiety levels and relevant factors that induced anxiety in radiologists.Methods: The research is a descriptive study, population constitudes, radiology residents, specialists and scholars actively working in Turkey during COVID-19 pandemic. The data of the study were collected digitally, through the clinical activity scale and Back anxiety scale questionnaires created over the internet. The data collection period started on 18.04.2020 and ended on 8.6.2020.Results: Eightysix radiologists completed the survey. It was understood that the radiologists working during the pandemic had a high level of personal anxiety and worked under stress (3,74). A weak linear relationship was found between the changes in the functioning of radiology clinics and the personal concerns of radiology physicians at the p=0.05 error level (0.224). They stated that unnecessary thorax computed tomography (CT) demands increased (4,51) and they made the most thorax CT evaluation in the daily routine (4,42).Conclusion: In our study, it was shown that there were significant changes in the functioning of radiology clinics especially related with increased thorax CT scans at the beginning of the COVID-19 pandemic and that the anxiety levels of radiologists increased due to the pandemic.
Variations in Apelin Expression Levels during Achilles Tendon Healing
Authors: ÇIRAKOĞLU Derya , ÇIRAKLI Alper , ERDEM Havva , UZUN Erdal , AKÇAY ÇELİK Mürüvvet
Published: April 2021

Objective: Research in recent years focused on the role of the apelin-APJ axis in pathologic fibrosis. The axis includes the parenchyma and mesenchymal cells of most organs. Reduction in parenchymal cells and activation of fibroblasts generally results in fibrosis of the organ. In this study, the aim was to reveal differences in apelin in tendons with primary repair.Methods: The study used 15 male Wistar Albino rats. The tendons of the right and left legs of the rats were used. Rats were divided into 3 groups containing 5 rats each. Group 1 was the sham group; Group 2 had tendon repair performed and were sacrificed 3 weeks later; and Group 3 had tendon repair and were sacrificed 6 weeks later. Under anesthesia, bilateral tendonectomy was performed and surgically repaired. Tendons were removed in the 3rd and 6th weeks. Samples were immunohistochemically stained for apelin and stain degree was assessed from 0 to 4 with a light microscope. The scores were compared with the Friedman test.Results: The results of statistical evaluation identified that the sham group had statistically significantly higher levels compared to the scores in the other two groups. There was no significant difference identified between the groups sacrificed in the 3rd and 6th weeks.Conclusion: This study concluded that apelin may be beneficial for tendon healing and that apelin levels may increase with fibrosis.
Predictive Role of Large Unstained Cells (LUC) and Hematological Data in the Differential Diagnosis of Orchitis and Testicular Torsion
Authors: KESEROĞLU Buğra Bilge , GÜNGÖRER Bülent
Published: April 2021

Objective: The main aim of this retrospective evaluation of patients presenting with the complaint of acute scrotal pain was to investigate whether large unstained cells (LUC) in the hematological data, percentage of LUC, and the other haematological parameters would be of benefit in differential diagnosis. The secondary aim was to investigate the utility of LUC and LUC% as a new biochemical marker in the differential diagnosis of TT and EO.Methods: In this study, a retrospective evaluation was made of patients who presented with the complaint of acute scrotal pain at the emergency polyclinic. The patients were evaluated in three groups; testicular torsion, orchitis, and the control group. Primarily the large unstained cell and other hematological data of the patients were evaluated.Results: Statistical differences were evaluated in LUC, LUC%, platelet, neutrophil, leucocyte, mean platelet volume, neutrophil / lymphocyte, platelet / lymphocyte values among the groups (p values respectively 0.001, ˂0.001, 0.491, ˂0.001, ˂0.001, 0.031, ˂0.001, 0.001). The cutoff values for the differentiation of epididimo-orchitis (EO) were determined in the differential diagnosis of EO and TT. The highest area under curve values were found for LUC, LUC% and neutrophils, respectively, 0.752 (0.660-0.843), 0.698 (0.605-0.790), 0.383 (0.284-0.482).Conclusion: The results of this study showed that the LUC and LUC% values obtained from complete blood count (CBC) can be reliably used in the differential diagnosis of EO and TT
Determining the Effects of Women’s Fertility Awareness Levels on Obstetric History
Authors: ÖZŞAHİN Zeliha , ALTIPARMAK Sümeyye
Published: April 2021

Objective: This study was conducted using the Google Forms platform to determine the effects of women's fertility awareness on their obstetric histories.Methods: The sample of this cross-sectional study consisted of 365 women between the ages of 18 and 49 who visited three family health centers in eastern Turkey. The data has been collected via Google Form. Data were collected using the Personal Information Form and the Fertility Awareness Scale (FAS). Descriptive statistics (n, %, mean, standard deviation, min-max), Cronbach alpha, Pearson correlation, chi-square and independent sample t-test were used in statistical analysis.Results: 365 women participated in the study. The women with a mean age of 34.25±6.82 had a mean score of 38.74±6.45 in the Bodily Awareness dimension of FAS, a mean score of 32.14±5.28 in the Cognitive Awareness dimension of FAS, a mean total score of 70.89±10.50 in FAS, and they were determined to have a high level of fertility awareness (61.1%). The participants’ mean scores of Bodily Awareness were determined to decrease with their age of marriage and age of first childbirth (p<0.05). The mean FAS total and dimension scores of the women who were employed, those who had a high level of education, those who had a good economic status and those who used modern family planning methods and trust these methods were determined to be higher (p<0.05). The women who had sexually transmitted diseases and reproductive system infections in the past were determined to score higher, while the women who had problems during the conception process and pregnancy were determined to score lower (p<0.05). Among women surveyed, it was determined that miscarriage, abortion, stillbirth and having a dead child did not affect fertility awareness.Conclusion: In this study, among women surveyed, fertility awareness was observed to be affected by socio-demographic characteristics such as marriage age, first childbirth age, employment status, and economic status. It was determined that the women who used modern contraceptives and trusted these methods and the women who had sexually transmitted diseases and reproductive system infections in the past had high fertility awareness, whereas the women with low fertility awareness had health problems during the conception process and pregnancy.
Political formation in the bojo of university pedagogy: implications in the formation of future teachers
Authors: Silva Fabrício Oliveira da , Lopes Maria da Conceição Oliveira , Santana Jescilda Ferreira de Macedo
Published: April 2021

Based on the assumption that political education guides collective life and demands to equip the subject to build a fair, democratic and inclusive society and that participation in school generates political learning for participation in society in general, this work analyzed how university teaching weaves processes of critical education, the policy of students in training, in order to impact the future educational practices of the basic school. The research was based on the discussion of political education and university pedagogy, taking into account the contributions of qualitative methodology, with the option of a semi-structured interview. The participating subjects were nine students graduating from undergraduate courses at a public state university. The analysis of the data carried out, using the Thematic Analysis technique, allows us to conclude that political education does not occupy the center of the concerns of university pedagogy, with issues of social urgency being supplanted by the plastering of the curriculum. The debate comes to the fore only in the specific subject at the end of the course, thus distorting the concept of politics as necessarily a daily practice.
Innovation-driven growth in the regions of the Russian federation and the activities of national research universities: analysis of relationship
Authors: Glebova Irina Stanislavovna , Berman Svetlana Sergeevna , Abramov Ruslan Agarunovich , Lvov Ilya Nikolaevich
Published: April 2021

The university funding programs focused on regional economic development and “smart specialization” goals are focused on “discovering entrepreneurial potential”, which employs the instrument of a structured dialogue among four key actors in the innovation process: public authorities, business structures, research organizations, and representatives of the civil society. The authors analyze the relationship between the results of the activities of national research universities (NRUs) in Russia and the dynamics of innovation-driven growth of the regions in which they are located, based on their methods. The purpose of the study is to search for new tools for interaction between universities and actors of regional innovation-driven growth.
Higher education strategies for the 21st century: philosophical foundations and the humanist approach
Authors: Mielkov Yurii , Bakhov Ivan , Bilyakovska Olha , Kostenko Larysa , Nych Tamara
Published: April 2021

The paper is dedicated to a philosophical consideration of the transformation strategies for higher education, particularly those revealed by the current Covid-19 pandemic. The situation of the latter is presented as a particular form of the general VUCA characteristics of the today’s world of uncertainty, unpredictability and qualitative complexity (‘supercomplexity’). It is argued that the main result of our acknowledgement of the VUCA situation in the world for higher education is the image of the developed human personality becoming the main value and at the same time the main goal of higher education. Under the conditions of volatility and ambiguity, any existing ‘ready-made’ knowledge, as well as any instructions for effective rational behavior, turns to be inadequate. Because of that, it is no longer sufficient to have a set of ‘competences’ as a final result of the educational process at today’s university. Higher education has to turn to developing in its graduates certain multidisciplinary qualities, like critical independent thinking and ability to create one’s own knowledge, up to aiming at an all-round development of cultured personality. The paper argues that the education of critical and creative thinking is closely related to the transition to student-centered learning, as each individual student is to become a full-powered subject of the educational process according to one’s own interests, abilities and curricula, with the role of a teacher starting to resemble that of a moderator, the one who is to help his or her undergraduates to navigate through the vast ocean of available information in order for them to choose and to create their own, personal knowledge. The latter task is especially enforced by the distant and online learning having become popular during the Covid-19 pandemic: that form of learning puts especially high demands on self-discipline and self-responsibility of a student’s personality, while presenting itself as rather a supplement than a replacement to more traditional forms of higher education with personal communication between student and teacher.
SELERA MASYARAKAT DALAM MENENTUKAN PERUMAHAN DI KABUPATEN SUKOHARJO DENGAN METODE FUZZY-AHP
Authors: Setiono Setiono , Koosdaryani Koosdaryani , Suryoto Suryoto , Ulyanisa Nur
Published: April 2021

Keberadaan Kabupaten Sukoharjo yang merupakan daerah berkembang, dimana beberapa kegiatan perekonomian bertaraf internasional, pendidikan, layanan kesehatan dan sektor informal. Dengan kondisi demikian maka banyak para pendatang dari daerah sekitar maupun dari luar daerah yang datang dengan tujuan bekerja, sekolah, berdagang dan sebagainya. Keadaan ini di satu sisi menimbulkan masalah tempat tinggal bagi masyarakat pendatang, tetapi di sisi lain merupakan peluang pengembangan perumahan untuk menyediakan sarana hunian dengan membangun perumahan-perumahan yang dibutuhkan. Tujuan penelitian ini yaitu untuk mengetahui selera dan faktor yang paling mempengauhi masyarakat dalam memilih perumahan di Kabupaten Sukoharjo. Penelitian ini dilakukan dengan mengumpulkan data primer dan sekunder yang berupa hasil dari kuisioner kepada masyarakat terkait. Peninjauan langsung terhadap kondisi terkini masing-masing perumahan serta pengkajian terhadap masing-masing faktor terpilih. Setelah data terkumpul dilakukan penilian terhadap kriteria dan kemudian penilaian terhadap alternatif dan dilakukan pembobotan. Penelitian ini menggunakan metode Fuzzy-AHP dengan bantuan Software Microsoft Excel 2010. Berdasarkan penelitian yang telah dilakukan, faktor legalitas merupakan faktor yang paling berpengaruh dalam memilih perumahan yaitu sebesar 33,22%. Faktor yang berpengaruh kedua yaitu faktor keamanan dan kenyamanan sebesar 24,19%, kemudian faktor lokasi sebesar 21,81%, faktor kelengkapan rumah sebesar 13,58%, dan faktor persepsi harga sebesar 7,27%.
Evaluasi Pelaksanaan Program Pusat Sumber Pendidikan Inklusif di DKI Jakarta
Authors: Jaya Indra , Badrujaman Aip , Suparno Anna Suhaenah
Published: April 2021

Penelitian ini bertujuan untuk mengetahui efektivitas dan pencapaian implementasi program di pusat sumber daya sekolah pendidikan khusus yang ditetapkan oleh Dinas Pendidikan DKI Jakarta sebagai Pusat Sumber Daya Pendidikan Inklusif. Studi evaluatif ini dilakukan dengan metode mix-methode yang menggabungkan pendekatan kualitatif dan kuantitatif. Evaluasi dilakukan dengan model Context, Input, Process, Product and Outcome (CIPPO). Hasil penelitian menunjukkan bahwa: (1) Seluruh aspek dan indikator komponen konteks telah memenuhi kriteria; (2) Komponen masukan belum memenuhi kriteria; (3) Proses komponen belum memenuhi kriteria; (4) Komponen produk telah memenuhi kriteria; dan (5) Komponen hasil belum memenuhi kriteria.
Pengaruh Teknik Self-Instruction Dalam Pendekatan Cognitive Behavior Therapy untuk Meningkatkan Harga Diri Korban Perundungan
Authors: Salsabila Rahmah , Fitriyani Hilma
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh teknik self-instruction dalam pendekatan CBT untuk meningkatkan harga diri korban perundungan. Penelitian ini menggunakan metode penelitian subjek tunggal dengan desain A-B. Subjek dalam penelitian ini adalah seorang siswa laki-laki kelas VII SMP yang memiliki harga diri rendah berdasarkan hasil pengukuran harga diri instrumen coopersmith self-esteem inventory. Data yang diperoleh selama penelitian kemudian dianalisis dengan cara analisis dalam kondisi pada kondisi baseline (A) dan kondisi intervensi (B) serta dilakukan analisis antar kondisi baseline (A) dengan kondisi intervensi (B). Skor pada kondisi baseline cenderung stabil dan skor pada kondisi intervensi cenderung meningkat. Rata-rata skor harga diri sebelum dilakukan intervensi adalah 66 (berada pada kategori rendah) kemudian meningkat menjadi 93 (berada pada kategori sedang) setelah diberikan intervensi. Hasil persentase overlap pada penelitian ini memperlihatkan bahwa teknik self-instruction berpengaruh pada meningkatnya harga diri konseli.
Profil Dukungan Sosial-Psikologis Yang Dibutuhkan Dan Diperoleh Orangtua Dengan Anak Sakit Kanker (Survey Di Komunitas Kantong Doraemon)
Authors: Afifah Windi , Luawo Meithy Intan Rukia
Published: April 2021

Orangtua dengan anak sakit kanker membutuhkan dukungan sosial-psikologis untuk membantunya menghadapi kondisi yang ada. Dukungan sosial-psikologis adalah bantuan yang diterima oleh seseorang dari orang lain dalam bentuk dukungan emosional, bantuan instrumental, memberi informasi, penilaian diri dan interaksi yang mendukung agar dapat meningkatkan kualitas hidup seseorang. Tujuan penelitian ini untuk memperoleh gambaran mengenai dukungan sosial-psikologis yang dibutukan dan diperoleh orangtua dengan anak sakit kanker di komunitas kantong doraemon. Penelitian ini merupakan penelitian kuantitatif dengan metode survey. Populasi dalam penelitian ini adalah 20 partisipan yang memiliki anak sakit kanker di komunitas dengan menggunakan teknik sampling jenuh, yang berarti seluruh populasi digunakan. Pengumpulan data menggunakan instrumen angket sosial-psikologis yang dibutuhkan dan diperoleh. Temuan dari hasil penelitian ini adalah: (1) Dukungan sosial-psikologis yang dibutuhkan mendapatkan hasil pada tiga kategori, yaitu 45% tinggi, 35% sedang dan 20% rendah; (2) Dukungan sosial-psikologis yang diperoleh mendapatkan hasil pada tiga kategori, yaitu 25% tinggi, 55% sedang dan 20% rendah; (3) Dari lima indikator dukungan sosial-psikologis yang dibutuhkan dan diperoleh, masing-masing mendapatkan nilai yang beragam karena adanya berbagai faktor. Bagi orangtua dengan dukungan sosial-psikologis yang dibutuhkan dan diperoleh termasuk kategori tinggi maka akan berfungsi dengan baik karena kesesuaian diantara keduanya. Namun bagi orangtua yang belum memperoleh dukungan sosial-psikologis sesuai dengan yang dibutuhkan, maka penyedia dukungan berperan penting untuk memenuhi dukungan sosial-psikologis tersebut.