bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity
Authors: Daniels Lori B. , Antonini Paula , Marino Rossella , Rizzo Marianna , Navarin Silvia , Lucibello Serena Grazia , Maisel Alan S. , Pizza Vincenzo , Brenner David A. , Jeste Dilip V. , Di Somma Salvatore
Published: November 2019

Background

The Cilento region of southern Italy has a high prevalence of nonagenarians and centenarians. Few studies of the oldest old have included echocardiographic and/or electrocardiographic data, in a home-based setting.

Objectives

The objective of this pilot study was to delineate the key lifestyle, medical, echocardiographic, and electrocardiographic features of a sample of nonagenarians and centenarians and their younger cohabitants from Cilento, via a comprehensive, home-based cardiovascular assessment. The ultimate aim is to identify the cardiovascular profile and lifestyle factors associated with longevity.

Methods

Twenty-six nonagenarians and centenarians (mean age 94 ± 3 years) and 48 younger cohabitants aged 50–75 years (mean 62 ± 5) underwent a comprehensive cardiovascular evaluation in their homes.

Results

In contrast to their younger cohabitants, nonagenarians and centenarians did not smoke, had lower fasting glucose levels, and lower LDL cholesterol despite being half as likely to be taking statins, and showing similar adherence to a Mediterranean diet. Over half of nonagenarians and centenarians (15/26) remained autonomous with their activities of daily living. Prevalence of self-reported coronary artery disease and stroke among nonagenarians and centenarians was low (11.5%), though a significant number had atrial fibrillation (31%) or congestive heart failure (27%). Although 62% of nonagenarians and centenarians had at least moderate valvular disease on echocardiography, less than 25% of those affected reported dyspnea.

Conclusion

Nonagenarians and centenarians in the Cilento region had a healthy metabolic profile and a low prevalence of clinical cardiovascular disease. Even among nonagenarians and centenarians with structural heart abnormalities, report of symptoms is low. Larger studies in the Cilento population may help elucidate the mechanisms underlying cardiovascular health in the oldest old.
Bad Company: The Corporate Appropriation of Nature, Divinity, and Personhood in U.S. Culture
Authors: Hardack Richard
Published: November 2019

In this article, I provide a cultural history of some of the critical predicates of corporate personhood. I track the Hobbesian lineage of the corporate form, but also the ways the corporation, ascribed with numinous agency and personhood, has filled the cultural space vacated by our transcendence of anthropomorphic notions of god and Nature.

The corporation was created through the consent of the sovereign, and its charter was formulated to reflect not only its uses, but its potential threat, particularly with regard to its concentration of power. Established under the aegis of individual states, the U.S. corporation was initially restricted to specific functions for limited periods. But corporations in many contexts not only have supplanted the Hobbesian state that created them, but displaced the individual person.

Corporations have become super-persons and forms of sovereigns themselves, in part by acquiring human rights and “personalities” and tethering them to the corporation’s inhuman attributes. However, corporations don’t just mimic human behaviors; at best simulacra, or imitations of human life, corporations challenge and destabilize the status of personhood, and what it means to be a person.

In the process, corporations have amassed not just wealth, but personhood (for example, in perhaps surprising ways, the personhood of African Americans). In many ways, the ever-increasing wealth gap in the United States is actually a personhood gap. The overarching effect of corporate personhood, which operates in tandem with privatization, is to dehumanize people, turning them into things that have no rights. Created to encourage entrepreneurial (or reckless and socially irresponsible) risk-taking and minimize personal liability, the corporation evolved into an entity that dynamically diminishes the personal.

The corporation represents a collective, transcendental body that has taken on the role of a deity, and, in U.S. ontology, of nature. The relationships between human and corporate personhood and identity implicate fantasies of the supernal; the superhuman; immortality; and the transcendence of individuality. For these reasons, I treat the corporation not primarily as a commercial enterprise, but as a cultural phantasm, a kind of black hole that draws in more and more cultural phenomena into its orbit. The modern corporation has come to guarantee certain rights at a price, in much the way the Hobbesian state once did. People barter their attributes to corporations; but they are no longer trading liberty for security, but “souls” for identity. As the corporation comes to serve as the de facto guarantor and distributor of culture, it remains amoral at best, and in practice serves as a dominant pathological personality that helps reduce all human endeavor to commercial interest.
The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients
Authors: Hasan Md. Jahidul , Rabbani Raihan , Huq Shihan Mahmud Redwanul
Published: November 2019

Introduction

Sepsis is a life-threatening condition, and sepsis-associated thrombocytopenia (SAT) is a common consequence of the disease where platelet count falls drastically within a very short time. Multiple key factors may cause platelet over-activation, destruction and reduction in platelet production during the sepsis. Eltrombopag is a thrombopoietin receptor agonist and is the second-line drug of choice in the treatment of chronic immune thrombocytopenia (ITP).

Aim of the study

The objective of this study was to observe the therapeutic outcome of high dose eltrombopag in SAT management in critically ill patients.

Material and Methods

This 6-month-long single group, observational study was conducted on seventeen ICU patients with SAT. Eltrombopag 100 mg/day in two divided doses was given to each patient. Platelet counts were monitored. A low platelet blood count returning to 150 K/μL or above, is taken as indicative of a successful reversal of a thrombocytopenia event.

Results

The mean Apache II score of patients (n= 17) was 18.71 (p-value: >0.05). No eltrombopag-induced adverse event was observed among the patients during the study period. Thrombocytopenia events were reversed successfully in 64.71% of patients (11; n= 17) within eight days of eltrombopag therapy.

Conclusions

The therapeutic potentiality of high dose eltrombopag regime in the management of sepsis-associated thrombocytopenia was found clinically significant in over two-thirds of critically ill adult patients enrolled in the study. These data may point to a new strategy in the management of acute type of thrombocytopenia in septic patients.
Diagnostic Difficulties in a Severely Ill HIV Patient with Multiple Superinfections - A Case Report
Authors: Mănășturean Cristina , Oprea Cristiana , Oțelea Dan , Georgescu Anca Meda
Published: November 2019

Introduction

As chronic HIV infection is prone to co-infections more than any other infectious condition, many severely immune-depressed patients require advanced diagnostic investigations and complex treatment.

Case report

The case of a 30-year-old severely immune-depressed patient with AIDS, who developed neurological impairment and was diagnosed with encephalitis is presented. Multiple diagnostic approaches had to be used in order to identify the etiologic agents responsible for the clinical, immunological and biological evolution. Despite using advanced laboratory investigations and complex treatment, the patient developed multiple organ dysfunction syndromes that led to a fatal outcome.

Conclusions

Establishing etiologic relations and treatment priorities in patients with severe immunodeficiency and co-infections can prove difficult, underlining the need of rapid syndromic testing.
Setup of axial bearing capacity of open ended tubular steel piles driven in sand
Authors: Ahlinhan Marx Ferdinand , Adjovi Edmond Codjo
Published: November 2019

This paper focuses on the setup of axial bearing capacity of open ended tubular steel piles that are used for offshore foundation systems such as those of wind turbines. A comparative evaluation of the most commonly used models for setup prediction shows an upper estimate bound and a lower estimate bound, which correspond approximately to a setup rate of 60% increase per log cycle of time and 20% increase per log cycle of time, respectively. This finding is validated with the results of case histories reported in literature, which show that the setup values of most case histories considered lie in the best estimate zone between the upper estimate zone and the lower estimate zone. The analysis results show a minimum setup factor of approximately 1.5 for 100 days following end of driving of open-ended tubular steel pile driven in sand.
Selbsterlösung durch Erkenntnis - Die Gnosis im 2. Jahrhundert n. Chr.
Authors: von Ostheim Martin
Published: November 2019

Die Gnosis als Weg zur Erkenntnis Wer möchte nicht nach Erkenntnis streben? Gnostikerinnen und Gnostiker finden sie in ihrer Religion. Die Gnosis eröffnet ihnen eine neue, geistige Welt. Sie können die Welt des Materiellen verlassen und sich selber in die Welt der Äonen erlösen. Die Gnosis ist eine Religion unbekannten Ursprungs, die sich im zweiten Jahrhundert n.Chr. im gesamten Mittelmeerraum verbreitet hat. Das griechische Wort gnôsis bedeutet Erkenntnis – und das ist auch das Ziel der Gnosis und ihrer Vertreter. Gnostikerinnen und Gnostiker versuchen, durch Studium der gnostischen Schriften und gnostischen Kult, in Form einer persönlichen Erkenntnis Antworten auf die großen Fragen der Menschheit zu erlangen. Die Erkenntnis, woher wir kommen und wohin wir gehen, was der Urgrund unseres Seins ist, ist für Gnostiker eine Befreiung aus der diesseitigen, materiellen Welt und führt zur Selbsterlösung in eine neue, geistige Welt. Doch Gnostikerinnen und Gnostiker können am Pléroma, der Welt der Äonen, bereits hier vorweg Anteil nehmen. Ein Erlöser wird nicht benötigt. Christliche Kirchenväter haben gnostische Schulen vehement bekämpft. Diese waren eine Bedrohung für das junge Christentum. Gnostiker haben ihre Lehren aus dem Christentum und verschiedenen philosophischen Strömungen zusammengetragen. Den meisten gemeinsam ist die Annahme eines höchsten, vollkommenen Gottes und eines unvollkommenen Schöpfergottes, Demiurg genannt, der die materielle Welt und die Menschen erschaffen hat. Manchmal wird der Demiurg mit dem Gott des Alten Testaments identifiziert. Alle Menschen tragen in sich einen göttlichen Funken des höchsten Gottes. Diesen gilt es zu entdecken und sich aus dem negativ gedeuteten Materiellen in die geistige Welt zu retten – in den Texten wird dies oft bildhaft mit Licht und Dunkelheit oder Nebel und klarer Sicht umschrieben. Martin von Ostheim stellt in diesem Buch die Gnosis von Valentinus und seinem Schüler Ptolemaios vor. Aus dem Inhalt:   Die gnostischen Äonen Der Fall der Weisheit und die Entstehung der Materie Die Kosmogonie und die Lehre der drei Welten Der Mensch als dreiteiliges Wesen: Erkenne dich selbst! Das Leben nach dem Tod und die gnostische Erlösung
Pengaruh Pemberian Dosis Pupuk Kandang Ayam Petelur Dan NPK Mutiara 16:16:16 Terhadap Pertumbuhan Tanaman Lai Mahakam (Durio Kutejensis Hassk Becc) Belum Menghasilkan
Authors: Zainudin Zainudin
Published: November 2019

This study aims to determine the dose of laying hens manure and fertilizer NPK 16:16:16 Mutiara right and the interaction between the dosing laying hen manure and NPK 16:16:16 pearls in improving plant growth Lai Mahakam immature. The study was conducted over four months, from May to September 2015 starting from land clearance, maintenance of plants, to capture data. This research was conducted at Badak Mekar village, Muara Badak, Regency. The design of the study is a randomized block design factorial 3 x 3 with three replications. The first factor is the dose of chicken manure (K) consisting of 3 levels: K0 (control), K1 (10 kg / plant) and K2 (20 kg / plant). The second factor is the dose of fertilizer NPK 16:16:16 Mutiara (M) comprises 3 levels: M0 (Control), M1 (200 g / plant) and M2 (400 g / plant). The treatment dose of chicken manure had no significant effect on all parameters of observation. Treatment fertilizer NPK 16:16:16 Mutiara very significant effect on all parameters of observation. The best treatment for an average plant height increment of age 90 days after treatment was achieved by treatment M1 (200 g / plant) is 15.54 cm while the lowest treatment was achieved by treatment M0 (control) is 7.03 cm. Interaction between chicken manure and NPK 16:16:16 Mutiara not significantly affected all parameters of observation.
Pengaruh Berbagai Media Tanam Dan Pemberian Mikro Organisme Lokal (MOL) Keong Mas Terhadap Pertumbuhan Dan Produksi Tanaman Bawang Tiwai (Eleutherine americana )
Authors: Sumarno Sumarno , Mahdalena Mahdalena , Hamidah Hamidah
Published: November 2019

Onions Tiwai is one plant in Borneo forest used by people as a traditional medicine. One of the efforts to support increased production of onions tiwai is through the cultivation of technology media including by the use of appropriate planting and the provision of the Micro Organisms Local (MOL). The aim of research to know the influence of MOL conch mas on growth and yield of onion tiwai and to determine the best planting medium for the growth and production of onions tiwai. The study was conducted over four months starting from nursery seedlings until harvest. This study uses a randomized block design (RBD) with a 4 x 4 factorial experiment consisting of three replications. The first factor is the Growing Media which comprises four levels: ie m0 (Control), m1 (Topsoil and sand), m2 (Topsoil and Rice Husk) and m3 (Topsoil, Rice Husk and Sand). The second factor is the concentration of microorganisms Local (MOL) snails consists of four levels ie p0 (control) p1 (100 ml / liter water) p2 (200ml / liter of water) and p3 (300 ml / liter). The results showed that treatment of the planting medium (M) significantly affected the parameters of the number of leaf age 60 DAP and is not significantly affected, plant height, number of tillers, the number of bulbs, tubers and the weight of the growing media pH. While the provision of MOL Keong Mas (P) had no significant effect on all parameters. There is no interaction between the treatment plant and the provision of various media MOL Keong Mas on all parameters observed.
Respon Akar Tanaman Kelapa Sawit (Elaeis guineensis Jacq.) di Pre Nursery Pada Pemberian Air dan Pupuk Urea
Authors: Elidar Yetti
Published: November 2019

The research objective was to determine the effect of water and the volume of urea fertilizer and the interaction of both the oil palm plant roots in the nursery early (pre nursery). This research was conducted in the Nursery Faculty of Agriculture, University of Mulawarman, Samarinda from February to May 2014. The study using completely randomized design (CRD) factorial 3 x 4 with three replications. The first factor is the volume of water (A) in the planting medium consists of three levels, namely: a1 = 100 cc of water plants-1; a2 = 200 cc of water plants-1; a3 = 300 cc water plant-1. The second factor is the provision of urea fertilizer (P), which consists of four levels, namely: p0 = without fertilizer urea; p1 = urea 1 g L-1 water to 100 seedlings; p2 = urea 2 g L-1 water to 100 seedlings; PP3 = urea 3 g L-1 water to 100 seedlings. Number of treatment were 12 and each treatment was repeated three times and each replication consisted of three plants so the total number is 108 plants. Data were statistically analyzed and tested further by testing the smallest Significant Difference (LSD) at 5% level. The results showed that the water volume of 200 cc of plant-1 (p2) provides the highest root dry weight average of 254.13 g. While the interaction between the water volume of 200 cc of plant-1 and dose of urea 3 g L-1 water (a2p3) provides the highest root dry weight average of 300,00 g.
Potensi Pengembangan Tanaman Lada (Piper nigrum L) Pada Wilayah Kecamatan Muara Badak
Authors: Sopian Akhmad , Zainudin Zainudin
Published: November 2019

Farmers generally plant pepper on ultisol soil. Ultisol soil is classified as acid mineral soil which has a wide distribution, but has the potential to develop agricultural land including pepper plantations. The tendency of land used for agricultural activities shows a decrease in soil fertility, indicated by the occurrence of erosion, imbalance of nutrients present in the soil and stronger soil dependence on fertilizer, as well as lower crop production. The research aims to find out the characteristics of pepper land, productivity, potential land for the development of pepper plants in Muara Badak District. This research was carried out using survey methods with stages including; overlaying land maps, interviews, secondary data inventory, in the form of data on the number of farmers, land area, production and cultivation techniques, and analysis of soil samples in the laboratory. The results showed that the population / ha of pepper plants was different for each farmer, where the spacing was 110 x 110 cm, 120 x 120 cm, 130 x 130 cm and 140 x 140 cm with a population between 1300 - 4500 staples / ha. Farmers generally use lodrin organic fertilizer, but are not carried out intensively, and the land management system does not pay attention to the aspect of soil conservation, farmers' land has been cultivated for generations without using terraces and soil cover. The tendency of nutrient loss on the land is quite high because the land is located on a hill and is quite steep at 16-40% slope. Pepper productivity in the study area is quite high, with an average of 1,437 kg / ha. The highest productivity in Salo Palai village reached 1970 kg / ha, while the lowest in Batu Batu village was 830 kg / ha. The results of soil analysis in the two study locations that the content of the element N was classified as medium, the total K was classified as high to very high. pH and CEC are low, this can affect nutrient absorption, so that lime is needed and the addition of organic matter if fertilization is carried out.
Respon Akar Bibit Aren Genjah (Arenga pinnata) Di Pembibitan Pada Pemberian Dosis dan Interval Pupuk Organik Cair Nasa
Authors: Elidar Yetti
Published: November 2019

Research on the response of roots of palm sugar palm seeds (Arenga pinnata) in nurseries at doses and intervals of Nasa liquid organic fertilizer. Aims to determine the dosage, interval and combination of dosages and fertilization intervals with Nasa liquid organic fertilizer which can provide the best dry weight of the roots in the nursery. The research design used was a Completely Randomized Design (CRD) with 3x3 factorial experiments and each treatment was repeated 8 (eight) times, consisting of: the first factor was the treatment of POC Nasa dose in a concentration of 3 cc POC Nasa per liter of water (D) consists of 3 levels, namely: d1 = 300 ml POC Nasa, d2 = 400 ml POC Nasa, d3 = 500 ml POC Nasa, while the second factor is the treatment of POC Nasa Interval (I) consisting of 3 levels, namely: i1 = 2 once a week, i2 = once every 3 weeks, i3 = once every 4 weeks. The results of the POC Nasa dose study had a significant effect on leaf wet weight, leaf dry weight, root wet weight and root dry weight. The best dose at this level are: d2 (400 ml of Nasa liquid organic fertilizer), the interval of liquid organic fertilizer Nasa has a significant effect on leaf wet weight, leaf dry weight, root wet weight and root dry weight. The best dose at this level is: i1 (once every 2 weeks). The treatment combination has no significant effect on all parameters.
Aplikasi Pemupukan Terhadap Pertumbuhan Tanaman Aren Genjah (Arenga pinnata) dan Tanaman Kakao (Theobroma cacao) Pada Penanaman Sistem Jalur
Authors: Elidar Yetti
Published: November 2019

Planting with a lane system in palm sugar and cacao plants is a technique of plantation cultivation that aims at soil conservation and microenvironment. Plant cultivation in the field needs to get a supply of fertilizer to increase crop productivity. This study aims to determine the effect of giving SP-36 and KCl fertilizer to the best growth of sugar palm and cacao plants in the planting of path systems. The research was conducted on land in Badak Mekar Village, Muara Badak District, Kutai Kartanegara Regency, East Kalimantan. The research method used a Randomized Block Design (RBD) and repeated 4 times. Factorial experiments consisted of 2 factors, as the first factor was SP-36 fertilizer (p) consisting of 3 levels: p0 = 0 kg plant-1 (control); p1 = 0.25 kg of plant-1; p2 = 0.5 kg of plant-1. The second factor was KCl (k) fertilizer consisting of 3 levels: k0 = 0 kg plant-1 (control); k1 = 0.25 kg of plant-1; k2 = 0.5 kg of plant-1. The variables observed included: (1) Arenaceous plants: increase in caudal circumference, increase in the fifth midrib length, increase in the number of midribs, increase in number of leaflets on the fifth midrib and (2) Cocoa plants: increase in plant height, increase in stem circumference, the number of cocoa fruits, the intensity of pest and disease attacks on cocoa fruit. Observations on each variable were carried out at 3 and 6 months after treatment (mat). Data were analyzed by variance and if there were significant differences, it was followed by the Smallest Significant Difference Test (LSD) at the level of 5%. The results of the SP-36 fertilizer treatment showed very significant differences in all observation variables in early maturing palm trees and aged 3 bsp and 6 bsp cacao plants. The treatment of SP-36 fertilizer at a dose of 0.5 kg plant-1 (p2) gave the best growth of early maturing sugar palm plant 6 in the increase of the fifth midrib length, increase in bulb circumference, increase the number of midribs and increase the number of leaflets on the fifth midrib - each 137.17 cm, 25.58 cm, 3.25 strands and 39.08 strands. Likewise in the age of 6 bsp cocoa plants SP-36 fertilizer with a dose of 0.5 kg plant-1 (p2) gave the best growth in plant height increase, increase in stem circumference and number of cocoa fruit, each 18.92 cm, 8.25 cm and 25.25 pieces. The treatment of KCl fertilizer and the interaction between SP-36 and KCl fertilizers showed no significant difference in all observation variables in early maturing and cacao plants. Observations of pest and disease attacks on cocoa fruit with the intensity of pest attacks 0.00-23.47% were included in the category of minor damage and the intensity of disease attacks 0.00-66.30% which fall into the category of moderate damage.
Assessing the Impact of Off-grid Solar Electrification in Rural Peru
Authors: Jensen Michael , Hopps Eryn , Roth Brian
Published: November 2019

In rural communities throughout the developing world, lack of access to electricity can have far-reaching impacts. Students are often unable to study after sunset for want of adequate lighting; access to technology is limited or nonexistent for lack of power to charge devices. For one off-grid community in rural Peru, this was not a satisfactory situation, and they approached Engineers Without Borders-USA (EWB-USA) to work on a solution. Ultimately, after careful assessment and an enlightening false start, the Walla Walla University chapter of EWB-USA (EWB-WWU), in partnership with the community of Japura, designed and implemented standalone solar photovoltaic systems to electrify the community. The outline of this process is discussed in this article. A monitoring trip over a year after implementation allowed insight into the project’s health and sustainability and also taught the team lessons about training, communication, socioeconomic impact, and community empowerment. This assessment and the resulting lessons are the focus of this article.
EWB-USA and EPICS: Academic Credit, Community Impact, and Student Learning
Authors: Oakes William
Published: November 2019

EWB-USA engages thousands of students nationally on community-driven projects almost exclusively as an extra-curricular activity.  This paper documents how one EWB-USA chapter used the EPICS framework to merge the club into a credit-bearing program that leverages the infrastructure of the university and recognizes the faculty work within their respective teaching loads.  The approach preserves student leadership and ownership while enhancing student learning and accountability.  Student reflections were analyzed and showed evidence of learning of design as well as broader professional skills including communication, teamwork and project management.  Critical and reflective thinking is evident in the class artifacts.  Deeper learning including evidence of an awareness of ethnocentrism and positionality and bias were documented in the analysis of the student reflections.
Rebusan Daun Sirsak Efektif Menurunkan Kadar Asam Urat Pada Penderita Gout Artritis Di Kelurahan Lawangan Daya Kabupaten Pamekasan
Authors: Nur Moh , Denta Anggeria Oktavisa , Kuzzairi Kuzzairi
Published: November 2019

Asam urat yang berlebihan tidak akan tertampung dan termetabolisme seluruhnya oleh tubuh, sehingga akan terjadi peningkatan kadar asam urat dalam darah yang disebut sebagai perurisemia. Gangguan asam urat ditandai dengan suatu serangan tiba-tiba di daerah persendian. Nyeri yang timbul pada umumnya muncul secara tiba-tiba. Kemunculan secaratiba-tiba ini sering menyebabkan penderita asam urat sulit bergerak. Tujuan penelitian ini adalah untuk menguji efektivitas pemberian rebusan daun sirsak terhadap penurunan kadar asam urat pada lansia wanita penderita Gout Artritis.

Desain penelitian ini menggunakan rancangan penelitian dengan metode analitik (Pra ex. Design one group pre-post test design). Sampel penelitian ini adalah lansia wanita penderita gout artrhitis di Kecamatan Lawangan Daya sebanyak 14 responden. Pengambilan data menggunakan lembar observasi, hasil pengujian kadar asam urat dianalisis dengan uji statistik Paired T Test menggunakan SPSS.

Hasil penelitian menunjukkan P<0.05 artinya terjadi penurunan yang signifikan dari pemberian rebusan daun sirsat terhadap kadar asam urat Lansia Wanita penderita Gout Artritis di Kelurahan Lawangan Daya Kabupaten Pamekasan. Melihat hasil penelitian ini diperlukan pemberian rebusan daun sirsak secara rutin.

Kesimpulan dari penelitian ini adalah pemberian rebusan daun sirsak terbukti efektif dapat menurunkan kadar asam urat pada penderita Gout Artrhitis. Rebusan daun sirsak dapat dijadikan obat herbal yang tidak memiliki efek samping bagi penderita atau responden. 

 

Kata Kunci : Lansia wanita, daun sirsak, Gout Artritis.
ISOLATION OF AMNIOTIC FLUID MESENCHYMAL STEM CELLS (AF-MSCs) OBTAINED FROM CAESAREAN SECTIONS
Authors: Utama Bobby Indra
Published: November 2019

Amniotic fluid is a liquid that fills the amniotic cavity which has defense and nutritional functions in fetal development. Human aterm amniotic fluid can be an ideal alternative as a source of mesenchymal stem cells, originating from the neonate. Preclinical studies of second and third trimester amnion fluid cells confirmed the number of potential donors from this wasted material. In several studies, AF-MSCs express mesenchymal markers such as CD90, CD73 (SH3, SH), CD105 (SH2), CD29, CD166, CD49e, CD58 and CD44 (MHC class I). These cells also express HLA-ABC antigens, CD 34, CD 45 which are hematopoietic markers, and endothelial CD31 markers. There is no expression of CD10, CD11b, CD14, CD34, CD117, EMA and HLA-DR, DP, DQ antigens. Most of AF-MSCs have pluripotent properties which are characterized by the discovery of octamer binding protein 3/4 (Oct-3/4), transcription factors Nanog (Nanog), and stage-specific embryonic antigen 4 (SSEA-4) on RT-PCR examination. From this study, 8 million cells was isolated. These cells will be used for research on pelvic organ prolapse therapy by using AF-MSCs. AF-MSCs isolation totally takes 6 weeks. From 1 flask, 2 million of stem cells was obtained.
To Flex or Not to Flex? Is There a Relationship Between Lumbar Spine Flexion During Lifting and Low Back Pain? A Systematic Review With Meta-analysis
Authors: Saraceni Nic , Kent Peter , Ng Leo , Campbell Amity , Straker Leon , O'Sullivan Peter
Published: November 2019

Objective

To evaluate whether lumbar spine flexion during lifting is a risk factor for low back pain (LBP) onset/persistence or a differentiator of people with and without LBP.

Design

Etiology systematic review with meta-analysis.

Literature Search

Database search of ProQuest, CINAHL, MEDLINE, and Embase up to August 21, 2018.

Study Selection Criteria

We included peer-reviewed articles that investigated whether lumbar spine position during lifting was a risk factor for LBP onset or persistence or a differentiator of people with and without LBP.

Data Synthesis

Lifting-task comparison data were tabulated and summarized. The meta-analysis calculated an n-weighted pooled mean ± SD of the results in the LBP and no-LBP groups. If a study contained multiple comparisons (ie, different lifting tasks that used various weights or directions), then only 1 result from that study was included in the meta-analysis.

Results

Four studies (1 longitudinal study and 3 cross-sectional studies across 5 articles) included in meta-analysis measured lumbar flexion with intralumbar angles and found no difference in peak lumbar spine flexion when lifting (1.5°; 95% confidence interval [CI]: −0.7°, 3.7°; P = .19 for the longitudinal study and −0.9°; 95% CI: −2.5°, 0.7°; P = .29 for the cross-sectional studies). Seven cross-sectional studies measured lumbar flexion with thoracopelvic angles and found that people with LBP lifted with 6.0° less lumbar flexion than people without LBP (95% CI: −11.2°, −0.9°; P = .02). Most (9/11) studies reported no significant between-group differences in lumbar flexion during lifting. The included studies were of low quality.

Conclusion

There was low-quality evidence that greater lumbar spine flexion during lifting was not a risk factor for LBP onset/persistence or a differentiator of people with and without LBP. J Orthop Sports Phys Ther 2020;50(3):121–130. Epub 28 Nov 2019. doi:10.2519/jospt.2020.9218
Model Pengelolaan Eucalyptus pellita pada Hutan Industri Berkelanjutan
Authors: Yudistira Prisma , Karuniasa Mahawan , Wardhana Yuki Mahardhito Adhitya
Published: November 2019

PT. X adalah salah satu perusahaan pengelola Hutan Tanaman Industri (HTI) yang mendapatkan ijin seluas 296.262 ha. Penelitian ini bertujuan untuk menyusun model pengelolaan hutan tanaman industri yang berkelanjutan. Penelitian ini berfokus pada Eucalyptus pellita pada distrik Rasau Kuning, Provinsi Riau. Metode yang digunakan adalah Analytical Hierarchy Process (AHP) sebagai metode dalam model pengelolaan hutan tanaman industri. Aspek yang menjadi pembahasan dalam penelitian ini adalah peran silvikultur, pendapatan pekerja tidak tetap, pendidikan dan pelatihan, sarana dan prasarana produksi. Hasil penelitian menunjukkan bahwa analisis AHP terhadap peran silvikultur, pendapatan pekerja tidak tetap, pendidikan dan pelatihan terhadap potensi tegakan adalah silvikulur dengan nilai (0,523). Analisis AHP pada pengelolaan hutan tanaman industri yang berkelanjutan dengan hasil alternatif prioritas adalah sarana dan prasarana produksi (0,408) pada pengelolaan hutan tanaman industri. Penelitian ini membuktikan kriteria silvikultur dan alternatif sarana dan prasarana produksi mempunyai peran utama dalam model pengelolaan hutan tanaman industri yang berkelanjutan.Kata kunci:  Hutan Tanaman Industri, potensi tegakan, keberlanjutanManagement Model of Eucalyptus pellita in Sustainable Industrial ForestAbstractPT. X is one of the Industrial Plantation Forest companies that obtained a permit covering 296,262 ha. This study aim is to develop a model for sustainable industrial plantation management. This research focuses on Eucalyptus pellita in Rasau Kuning district, Riau Province.The method used is the Analytical Hierarchy Process (AHP) as a method in the industrial plantation management model. The results showed AHP analysis of the role of silviculture, income of precarious workers, education and training on the potential of stands was silviculur with a value (0.523). AHP analysis on sustainable industrial plantation management with priority alternative results is production facilities and infrastructure (0.408) in industrial plantation management. This research proves that silvicultural criteria and alternative production facilities and infrastructure have a major role in the sustainable industrial plantation management model.Keyword:  industrial plantation forests, potential of stands, sustainability
Perilaku Struktur Jembatan Baja Pelengkung Berdasarkan Spektrum Gempa
Authors: Apriani Widya , Lubis Fadrizal , Suryanita Reni , Sari Elva Nidya
Published: November 2019

[ID] Perencanaan struktur jembatan baja pelengkung harus memperhatikan kemampuan respon strukturnya yang rentan terhadap deteriorasi akibat fatik, ancaman gempa bumi kuat atau angin topan, khususnya diwilayah sumatera yang mempunyai resiko gempa yang tinggi. Penelitian ini fokus memprediksi  struktur jembatan pelengkung baja dengan analisis repons spectra dengan bantuan software analisis struktur gempa berdasarkan SNI 1726-2012. Percepatan gempa yang diambil berasal dari beberapa kota seperti Kota Aceh, Padang, Tanjung Pinang, dan Pekanbaru yang memliki karakteristik. Hasil analisis menunjukkan respon struktur jembatan terbesar terjadi di Padang dengan nilai perpindahan sebesar 0,016267 m dan percepatan sebesar 0,0235 m. Sementara itu, respons struktur terkecil terjadi di kota tanjung pinang dengan nilai perpindahan sebesar 0,01552 m dan nilai percepatan sebesar 0,0208 m. Diharapkan dengan diketahuinya hasil prediksi kesehatan struktur jembatan dapat digunakan sebagai referensi/masukan bagi pemerintah dan pihak yang terkait dalam usaha memperbaiki jembatan dengan tepat, sehingga diharapkan dapat mencegah terjadinya keruntuhan struktur jembatan.

[EN] Curved steel bridge structure planning must pay attention to the responsiveness of the structure that is vulnerable to deterioration due to fatigue, the threat of strong earthquakes or hurricanes, especially in the region of Sumatra which has a high earthquake risk. This study focuses on predicting the structure of steel curved bridges with spectral response analysis with the help of earthquake structure analysis software based on SNI 1726-2012. The earthquake acceleration taken came from several cities such as Aceh City, Padang, Tanjung Pinang, and Pekanbaru which have characteristics. The analysis shows the largest bridge structure response occurred in Padang with a displacement value of 0.016267 and acceleration of 0.0235. Meanwhile, the smallest structural response occurred in Tanjung Pinang city with a displacement value of 0.01552 and an acceleration value of 0.0208. It is expected that by knowing the results of the bridge structure health predictions can be used as a reference / input for the government and related parties in an effort to repair the bridge appropriately, so that it is expected to prevent the collapse of the bridge structure.
ANALYSIS OF METHODS TO INCREASE BRAND LOYALTY AMONG RUSSIAN TELEVISION CHANNELS
Authors: Nemirovskaya M. , Yakusheva V.
Published: November 2019

Based on the study of marketing activities of Russian TV channels of entertainment and educational segments the modern methods of attracting viewers to television brands have been analyzed. The objects of the study are seven well-known public broadcasters, whose business has established more than twenty-five significant and cost-effective ways to influence the loyalty of the audience. In combination with negative factors indirectly affecting the implementation of loyalty programs, taking into account the existing methods of other industries, a minimum independent evaluation of the effectiveness of loyalty, which can serve as an idea for new marketing developments, and will contribute to the development of scientific research in this economical area, has been suggested.
FEATURES AND PROBLEMS OF MONETARY REGULATION IN RUSSIA
Authors: Berdyshev A.
Published: November 2019

Based on the analysis of the particularities of the monetary policy of the Bank of Russia in the period 2000-2018, an assessment of its effectiveness has been carried out and the main problems in the sphere of monetary regulation have been identified. It has been determined, that the Bank of Russia focuses solely on ensuring price stability, limits the availability of credit for enterprises in the real sector of the economy, which significantly reduces their development potential. It has been shown, that under the conditions of unjustified monetary policy rigidity, the efficiency of the banking system’s function of transforming savings into investments is reduced. Thus, the easing of the monetary policy by the Bank of Russia is considered as a necessary condition for the development of national production.
3-Bromotetrazine: A Versatile Precursor for the Synthesis of 3-Monosubstituted s-Tetrazines and the Labelling of Macromolecules
Authors: Schnell Simon , Hoff Lukas , Panchagnula Advaita , Sieber Simon , Linden Anthony , Gademann Karl
Published: November 2019

We report the synthesis of the novel precursor 3-bromotetrazine and its successful use in the synthesis of various families of 3-monosubstituted s-tetrazines. A remarkable functional group selectivity is utilized to site-selectively functionalize different complex molecules. The unexpected stability of 3- bromotetrazine in aqueous media facilitated the development of a protocol for protein functionalization in- stalling a tetrazine unit as a bio-orthogonal handle for inverse electron demand Diels-Alder reactions. Addi- tionally, a novel tetrazine-based chemical probe was developed and its application in the context of thiol- targeted natural product isolation and labelling of mammalian cells is demonstrated.
Performance of Electronic Structure Methods for the Description of Hückel-Möbius Interconversions in Extended π-Systems
Authors: Woller Tatiana , Banerjee Ambar , Sylvetsky Nitai , Deraet Xavier , Proft Frank De , Martin Gershom , Alonso Mercedes
Published: November 2019

Expanded porphyrins provide a versatile route to molecular switching devices due to their ability to shift between several π-conjugation topologies encoding distinct properties. Taking into account its size and huge conformational flexibility, DFT remains the workhorse for modeling such extended macrocycles. Nevertheless, the stability of Hückel and Möbius conformers depends on a complex interplay of different factors, such as hydrogen bonding, p···p stacking, steric effects, ring strain and electron delocalization. As a consequence, the selection of an exchange-correlation functional for describing the energy profile of topological switches is very difficult. For these reasons, we have examined the performance of a variety of wavefunction methods and density functionals for describing the thermochemistry and kinetics of topology interconversions across a wide range of macrocycles. Especially for hexa- and heptaphyrins, the Möbius structures have a pronouncedly stronger degree of static correlation than the Hückel and figure-eight structures, and as a result the relative energies of singly-twisted structures are a challenging test for electronic structure methods. Comparison of limited orbital space full CI calculations with CCSD(T) calculations within the same active spaces shows that post-CCSD(T) correlation contributions to relative energies are very minor. At the same time, relative energies are weakly sensitive to further basis set expansion, as proven by the minor energy differences between MP2/cc-pVDZ and explicitly correlated MP2-F12/cc-pVDZ-F12 calculations. Hence, our CCSD(T) reference values are reasonably well-converged in both 1-particle and n-particle spaces. While conventional MP2 and MP3 yield very poor results, SCS-MP2 and particularly SOS-MP2 and SCS-MP3 agree to better than 1 kcal mol-1 with the CCSD(T) relative energies. Regarding DFT methods, only M06-2X provides relative errors close to chemical accuracy with a RMSD of 1.2 kcal mol-1. While the original DSD-PBEP86 double hybrid performs fairly poorly for these extended p-systems, the errors drop down to 2 kcal mol-1 for the revised revDSD-PBEP86-NL, again showing that same-spin MP2-like correlation has a detrimental impact on performance like the SOS-MP2 results.
In-situ Activation of a Highly Volatile and Thermally Stable Indium(III) Triazenide Precursor for Epitaxial Growth of Indium Nitride by Atomic Layer Deposition
Authors: O'Brien Nathan , Rouf Polla , Samii Rouzbeh , Rönnby Karl , Buttera Sydney C. , Ivanov Ivan G. , Kessler Vadim , Ojamäe Lars , Pedersen Henrik
Published: November 2019

Indium nitride (InN) is characterised by its superb electron mobility making it a ground-breaking material for high frequency electronics. The difficulty of depositing highquality crystalline InN currently impedes its broad implementation in electronic devices. Herein, we report a new highly volatile and thermally stable In(III) triazenide precursor and demonstrate its ability to deposit high-quality epitaxial hexagonal InN by atomic layer deposition (ALD). The new triazenide precursor was found to sublime at 80 °C and thermogravimetric analysis showed single step volatilisation with an onset temperature of 145 °C and negligible residual mass. Strikingly, two temperature intervals were observed when depositing InN films. In the high temperature interval, the precursor underwent thermal decomposition inside the ALD reaction chamber to produce a more reactive indium compound whilst retaining self-limiting growth behaviour. Stochiometric InN films with very low levels of impurities were grown epitaxially on 4H-SiC. This new triazenide precursor now enables ALD of InN for semi-conductor applications.
Lipid status and oxidative stress in menopausal women with obstructive apnea syndrome
Authors: Kolesnikova L I , Semenova N V , Osipova E V , Madaeva I M
Published: November 2019

Aim: to assess lipid profile, lipid peroxidation and antioxidant system parameters in peri - and postmenopausal women with obstructive sleep apnea syndrome (OSAS). Materials and methods. 37 perimenopausal women and 43 postmenopausal ones were examined. OSAS diagnosis was made on the basis of the clinical picture and the polysomnography results. In perimenopause, the main group consisted of 18 women, in postmenopausal women - 17. All comparison groups are comparable by age and body mass index. Lipid profile, lipid peroxidation and antioxidant system parameters by spectrophotometric methods were determined. Non - parametric criteria were used to analyze the group differences for the independent samples. Results and discussion. The increase of total cholesterol (TC) and low - density lipoprotein cholesterol (LDL-C) levels were observed in perimenopausal women with OSAS as compared to control. The increase of TC, triacylglycerol (TG), LDL-C, very - low - density lipoprotein cholesterol (VLDL-C) levels and decrease of high - density lipoprotein cholesterol (HDL-D) level were found in postmenopausal women with OSAS as compared to control. Accumulation of ketodienes and conjugated trienes in perimenopausal women with OSAS and thiobarbituric acid reactants with a decrease of total antioxidant activity of blood serum in postmenopausal women with OSAS as compared to control was observed. Moreover, postmenopausal women with OSAS have a higher lipid peroxidation substrates and diene conjugates levels with a lower α-tocopherol level and total antioxidant activity compared with perimenopausal patients.The integral indicator of oxidative stress assessment indicates an imbalance in the lipid peroxidation and antioxidant system in menopausal women with OSAS. Conclusion. The results obtained indicate a violation of lipid metabolism and the development of oxidative stress in patients with OSAS. This is most pronounced in the postmenopause due to the aggravation of the pathological condition.
Diabetic macroangiopathy
Authors: Verbovoy A F , Pashentseva A V , Verbovaya N I
Published: November 2019

Diabetes mellitus represents a significant medico - social problem for health care around the world. The main reason for an invalidism and a mortality of patients with diabetes mellitus are the lesions of heart and vessels united in the concept "diabetic macroangiopathty". This complication is often taped already at the time of diagnosis of a diabetes mellitus and demands active treatment.
10-year risk of fractures (FRAX) in people with diabetes type 2
Authors: Mazurenko E S , Malutina S K , Shcherbakova L V , Hrapova Yu V , Isaeva M P , Rymar O D
Published: November 2019

Aim. To study indicators of bone mineral densit (BMD) and trabecular bone score (TBS) and to reveal the 10-year fracture risk (FRAX®) taking into account the data obtained in persons with type 2 diabetes (DM2). Materials and methods. A clinical study of the type of case - control. The study included 122 people with and without DM2. All persons were: questionnaires, anthropometry, densitometry, determination of TBS and fracture risk on the FRAX®. Results and discussion. Persons with DM2 who underwent a fracture had lower T-score values in all areas except the spine, unlike those with DM2, but without fracture. However, persons with DM2 had a fracture at high values of T-score in vertebrae and hips in comparison with persons without DM. Using the TBS, we did not get a significant difference in any of the examined groups. We also found no differences in the risk of recurrent fractures among women with and without DM2 using FRAX® without densitometry and FRAX® adjusted for TBS. The values of FRAX® by T-score in the group of persons with DM with fractures were significantly lower (p=0.029 for major fractures, p=0.024 for hip fractures) than in persons without DM with fractures. Conclusion. Persons with DM2 and fractures have higher BMD values, lower than the FRAX fracture risk values adjusted for the T-score, do not differ significantly in TBS, which determines the difficulties in diagnosis, the need to find additional methods for early diagnosis of increased fracture risk in patients with DM2.
Ghrelin deficiency in patients with type 2 diabetes: the relationships with obesity, adipose tissue dysfunction and glucose variability
Authors: Klimontov V V , Bulumbaeva D M , Fazullina O N , Orlov N B , Konenkov V I
Published: November 2019

Aim. Ghrelin, a peptide hormone mostly produced by stomach, plays an important role in regulation of feeding behavior, energy balance and glucose homeostasis. The aim: to determine the relationships between fasting serum levels of ghrelin, body composition, adipose tissue endocrine function and glucose variability (GV) in type 2 diabetic subjects with and without obesity. Materials and methods. We observed 124 individuals with type 2 diabetes, including 42 non - obese subjects and 82 patients with obesity. Thirty non - obese healthy subjects were acted as control. The concentrations of ghrelin, leptin, resistin, and visfatin in the fasting serum were determined by Multiplex analysis. Body composition was assessed with DEXA. The 24-hour and nocturnal GV parameters were derived from continuous glucose monitoring. Results and discussion. Ghrelin levels in patients with diabetes were decreased significantly as compared to control (p