bluuebunny/crossref_metadata_2025 huggingface dataset:
The Case for Mom and Dad
Authors: Sullins D. Paul
Published: March 2021

Is the system of norms comprising traditional, natural marriage—featuring formally enacted, irrevocable, exclusive man/woman sexual union preceded by chastity—essential for children’s development and well-being, as Catholic teaching asserts? Review of an extensive body of diverse research finds that, compared to children continuously living with two parents, married parents, or their own biological parents, children in other family arrangements consistently experience lower emotional well-being, physical health, and academic achievement. Competing research has variously attributed this difference to a lack of married parents, two parents, complementary man/woman parents, or family stability, but these possibilities have not previously been studied in combination. To address this question, family structure differences and determinants of child well-being (reverse coded to show child distress) were examined using the 2008–2018 National Health Interview Surveys ( n = 82,635). Adjusted odds ratios (AOR) for child emotional problems were higher with less than two parents (AOR = 1.42, 95% CI 1.27–1.56), unmarried parents (1.46, 95% CI 1.31–1.61), unstable parents (1.55, 95% CI 1.27–1.76), or less than two biological parents (AOR = 1.70, 95% CI 1.55–2.87 for one biological parent; 4.77, 95% CI 3.95–5.77 for no biological parents). When combined in the same model, only the lack of joint biological parentage accounted for higher distress, with outcomes significantly worse without the biological father than without the biological mother (interaction AOR = 1.33, 95% CI 1.04–1.71). This evidence strongly supports the claim that maximum child development occurs only in the persistent care of both of the child’s own biological parents. Marriage benefits children primarily by ensuring such care. Implications are discussed.

Children raised apart from the care of both natural parents consistently experience lower developmental outcomes. Traditional, religious marriage norms—a lifelong, exclusive sexual union between man and woman—benefit children by establishing strong conditions that promote such care. More than any other family arrangement, marriage assures to children the care of their own mom and dad.
Community Versus Hospital Opioid-Related Overdose Deaths in Illinois
Authors: Feinglass Joe , Walker Garth , Khazanchi Rushmin , Rydland Kelsey , Tessier Robert Andrew , Mason Maryann
Published: March 2021

Objective

To better understand approaches to reducing mortality from the opioid epidemic, we analyzed in-hospital versus community opioid-related overdose deaths in Illinois.

Methods

We used data from the Statewide Unintentional Drug Overdose Reporting System (July 2017 through December 2018) to identify deaths that occurred in hospitals and communities (ie, homes or public spaces). We used census tract–level data for 34 Illinois counties to create bivariate mapping by overdose death rates. We used logistic regression to analyze the association of demographic and overdose characteristics with the likelihood of death in a hospital versus a community.

Results

During the study period, 2833 opioid-related overdose deaths occurred in 24 Illinois counties, 655 (23.1%) of which occurred in the hospital; of 2178 community deaths, 1888 (86.7%) occurred in the same census tract as the decedent’s recorded residence and 1285 (59.0%) occurred in the decedent’s home. Non-Hispanic Black people were 1.63 (95% CI, 1.27-2.10) times more likely than non-Hispanic White people to die in a hospital. Decedents from suburban Cook County and other Chicago suburban counties were significantly more likely to die in the hospital than decedents from Chicago or other Illinois counties. Documentation of a previous overdose, history of opioid use, and having bystanders present were significantly associated with hospital deaths. Evidence of a rapid overdose, fentanyl present, or prescription opioids were significantly associated with deaths in a community.

Conclusions

The high number of opioid-related overdose deaths in the community illustrates the need to decriminalize illicit drug use and facilitate treatment seeking. Establishing supervised safe consumption sites may have the biggest effect in reducing the number of opioid-related overdose deaths.
Gandhi and the Global Satyagraha
Authors: Jahanbegloo Ramin
Published: March 2021

It is a common view to say that satyagraha was conducted by a person like Gandhi who was brought up in a cultural setting familiar with the concept of self-suffering and non-violence. But it would be a mistake to judge the Gandhian satyagraha in terms of cultural background. The recent global history of non-violent action has shown us clearly that satyagraha is a seed that can grow and flourish in other cultures and religions as well. Among the followers of Gandhi in the twentieth century who successfully launched their own satyagraha against racial, religious and economic injustice and struggled for human rights are names such as Khan Abdul Ghaffar Khan, Martin Luther King Jr, Nelson Mandela, Lech Walesa, Vaclav Havel, Benigno Aquino and Aung San Suu Kyi. The trans-Indian experience of satyagraha assumes that non-violence in its broadest sense remains exemplary as a political action and is transferable as a human experience from one tradition of thought to another, making it universally applicable as a method of action.
Reconstruction of Anterior Mandibular Defect Using Submental Island Flap Pedicled With Mental Artery
Authors: Xing Ruxiao , He Jingya , Wang Feng , Liu Jinzhong , Sun Bin , Zhang Wei
Published: March 2021

Gingival carcinoma is a common malignant tumor occurring in the anterior area of the mandible, which can be derived from the epithelium of gingival mucosa. Surgical extended resection is the main treatment of gingival cancer, which can lead to anterior mandibular defect including mouth floor and mandible and mucosa of lower lip. According to the size of the defect, the common repair method is free musculocutaneous flap with vascular pedicle or pedicle flap. We present a method of repairing mandibular anterior tooth defect with an island flap pedicled with the mental artery.
Effects of L1 morphological type on L2 morphological awareness
Authors: Wu Zhaohong , Juffs Alan
Published: March 2021

Previous studies on bilingual children have shown a significant correlation between first language (L1) and second language (L2) morphological awareness and a unique contribution of morphological awareness in one language to reading performance in the other language, suggesting cross-linguistic influence. However, few studies have compared advanced adult L2 learners from L1s of different morphological types or compared native speakers with advanced learners from a morphologically more complex L1 in their target-language morphological awareness. The current study filled this gap by comparing native English speakers (analytic) and two L2 groups from typologically different L1s: Turkish (agglutinative) and Chinese (isolating). Participants’ morphological awareness was evaluated via a series of tasks, including derivation, affix-choice word and nonword tasks, morphological relatedness, and a suffix-ordering task. Results showed a significant effect of L1 morphological type on L2 morphological awareness. After accounting for L2 proficiency, the Turkish group significantly outperformed the Chinese group in the derivation, morphological relatedness, and suffix-ordering tasks. More importantly, the Turkish group significantly outperformed the native English group in the morphological relatedness task even without accounting for English proficiency. Such results have implications for theories in second language acquisition regarding representation of the bilingual lexicon. In addition, results of the current study underscored the need to guard against the comparative fallacy and highlighted the influential effect of L1 experience on the acquisition of L2 morphological knowledge.
Very rare case of Graves’ disease with resistance to methimazole: a case report and literature review
Authors: Mori Yusaku , Hiromura Munenori , Terasaki Michishige , Kushima Hideki , Ohara Makoto , Fukui Tomoyasu , Takahashi Yasuyoshi , Yamagishi Sho-ichi
Published: March 2021

Background

Methimazole (MMI) is used to treat hyperthyroidism in Graves’ disease. It is rare to encounter patients in whom hyperthyroidism cannot be controlled using high doses of MMI. Case presentation: A 21-year-old woman was referred to our hospital because of MMI-resistant Graves’ disease. Although her MMI dose had been increased to 120 mg/day, her serum thyroid hormone concentration was too high to be measured. Additional therapy with lithium carbonate, and then with dexamethasone and inorganic iodine, was initiated. After 14 days, the patient’s serum thyroid hormone concentration normalized, while she was taking 150 mg/day MMI, 800 mg/day lithium carbonate, 6 mg/day dexamethasone and 306 mg/day inorganic iodine, and total thyroidectomy was then performed. The patient was discharged 8 days after the thyroidectomy and experienced no major complications.

Conclusions

We have presented a rare case of Graves’ disease that was resistant to high-dose MMI. Combination therapy of MMI with lithium carbonate, dexamethasone and inorganic iodine may represent a therapeutic option for the preoperative preparation of patients with MMI-resistant Graves’ disease.
Differences between diabetic and non-diabetic nephropathy patients in cardiac structure and function at the beginning of hemodialysis and their impact on the prediction of mortality
Authors: Tang Chao , Ouyang Han , Huang Jian , Zhu Jing , Gu Xiaosong
Published: March 2021

Objectives

To characterize differences in cardiac structure and function in hemodialysis (HD) patients with diabetic nephropathy (DN) and in those without using echocardiography and to determine their impact on the prediction of mortality using echocardiographic parameters.

Methods

Clinical, laboratory, and echocardiographic data were collected from patients commencing HD.

Results

Compared with those without DN, patients with DN had lower peak velocity of the early diastolic wave (e′), larger left atria, and higher peak early diastolic velocity (E)/e′ and peak velocity of tricuspid regurgitation (TR). In addition, a larger proportion of DN patients had a combination of left ventricular (LV) diastolic dysfunction, cardiac valve calcification, moderate-to-severe cardiac valve regurgitation (CVR), and at least moderate pericardial effusion (PE). After accounting for age, sex, smoking, hypertension, hemoglobin, and albumin, DN was responsible for e′  < 10 cm/s, E/e′ >13 m/s, TR >2.8 m/s, LV diastolic dysfunction, CVR, and PE. LV diastolic dysfunction and E/e′ >13 were the most useful predictors of mortality in patients with DN.

Conclusions

Patients with DN who undergo HD tend to have worse LV diastolic function and are more likely to have heart valve problems. LV diastolic dysfunction and E/e′ are predictors of death in DN patients.
Reversing the catastrophe of neoliberal-led global capitalism in the time of coronavirus: Towards a democratic socialist alternative
Authors: Neilson David
Published: March 2021

This article first outlines key arguments that demonstrate how the ‘neoliberal model of development’s’ global unleashing of capital is leading human civilisation to the brink of collapse. This ‘intellectual pessimism’ informs the ‘optimistic will’ central to the second part of this article which outlines an alternative democratic socialist model of development. This alternative is founded on a project of global cooperation to construct a national-trans-national regulatory architecture that can facilitate an ecologically balanced, materially secure, flexible and democratically solidaristic collection of local accumulation regimes that in aggregate would comprise a sustainable, progressive and pandemic-preventing planetary mode of accumulation.
Stress Urinary Incontinence: Treatment With Platelet-Rich-Plasma Injection and Placement of Polydioxanone Threads—A Pilot Study
Authors: Luksenburg Ariel , Barcia Juan J. , Sergio Roberto , Fernandez Santiago , Pelosi Marco A. , Pelosi Marco A.
Published: March 2021

Stress urinary incontinence is an important clinical problem that affects millions of women worldwide. The aim of this article was the evaluation of a minimally invasive procedure as an alternative treatment for mild urinary stress incontinence in women, using platelet-rich-plasma (PRP) injections and polydioxanone (PDO) threads. A total of 23 patients with mild urinary incontinence, mean age 46, were evaluated with detailed history, examination, urinary diary, complete laboratory tests, ultrasonography, urodynamic studies, and completion of International Consultation on Incontinence Questionaire–Urinary Incontinence Short Form (ICIQ-UI SF). Under local anesthesia, PRP was injected through the anterior vaginal wall, PDO threads placed in paraurethral, suburethral, and lateral urethrovaginal spaces, using instruments developed for safe and effective performance. Patients were analyzed at 1, 2, 4, 8 weeks and 6 months posttreatment. A total of 10 patients were biopsed preoperatively and 60 days after treatment. Symptoms and ICIQ-UI SF score were significantly improved. Postoperative urodynamic studies were normal in all cases. Biopsies after treatment showed a dense connective tissue tridimensional mesh. No complications or adverse effects were observed. All patients declared satisfaction with results, will have the procedure again, and will recommend it. The minimally invasive technique presented here results in strengthening of the paraurethral, suburethral, and lateral urethrovaginal spaces and the mucosa of the anterior vaginal wall. The combination of PRP injections and the placement of PDO threads creates a fibrotic and absorbable mesh-like structure, aimed to increase the urethral resistance, so that under effort the intravesical pressure does not overcome the urethral pressure. These results suggest that the procedure is safe and a cost-effective alternative in patients with mild urinary incontinence, reducing the need for invasive surgical procedures. Larger studies are needed to confirm the results of this study.
Family Matters in Ontario: Understanding and Addressing Homelessness Among Newcomer Families in Canada
Authors: Forchuk Cheryl , Russell Gordon , Richardson Jan , Perreault Chantele , Hassan Heba , Lucyk Bryanna , Gyamfi Sebastian
Published: March 2021

Background

Canada, a key player in global humanitarian affairs is faced with enormous challenges in relation to housing and homelessness. As international migration continues to occur, homelessness among immigrant families is increasing worldwide; a situation that needs urgent attention and action.

Purpose

We designed this study to explore the needs of homeless families, identify risk factors associated with family homelessness, and to find strategies that could assist in mitigating and preventing homelessness among families in Canada.

Methods

This paper reports qualitative findings from a focused ethnographic study embedded in participatory action research that explored the experiences of 11 immigrant families with housing challenges in Ontario Canada.

Results

Thematic analysis yielded five (5) major themes: life challenges; lack of understanding of the system; difficulty with conflict resolution; escaping as a solution for hardship; and reducing immigrant family homelessness.

Conclusion

Findings from the study highlight the urgent need for advocacy and a well-tailored supportive housing policy to address family homelessness in Ontario.
Head circumference trajectory in children with perinatal stroke
Authors: Leong Amanda , Floer Amalia , Kirton Adam , Mineyko Aleksandra
Published: March 2021

Background:

Perinatal stroke is a leading cause of hemiparetic cerebral palsy and lifelong disability. Neurodevelopmental outcomes are difficult to predict and markers of long-term poor outcome continue to be investigated. Deceleration in growth of head circumference has been associated with worse developmental outcomes in neonatal brain injury. We hypothesized that perinatal stroke would result in decreased rates of head growth during childhood that would be associated with worse developmental outcomes.

Methods:

Patients with magnetic resonance imaging (MRI)–confirmed neonatal arterial ischemic stroke and arterial presumed perinatal ischemic stroke were identified from a population-based research cohort (Alberta Perinatal Stroke Project). Demographics and occipital-frontal circumference data were collected from medical records. Head growth was compared to typically developing control charts using a 2-tailed t test. The Fisher exact test was used to examine associations between Pediatric Stroke Outcome Measures (PSOM) scores and occipital-frontal head circumference.

Results:

Three hundred fifteen occipital-frontal head circumference measurements were collected from 102 patients (48 female, 54 male), over a median of 3.2 years (standard deviation = 5.18, range = 0-18.3). After 3 months for female patients and 1 year for male patients, occipital-frontal head circumference deviated and remained below normal growth trajectories ( P < .05) with a large effect size (Cohen d >0.8). Poor outcome (PSOM ≥ 1) was associated with smaller occipital-frontal head circumference ( P < .05).

Conclusion:

Head growth deceleration is observed in children with perinatal arterial ischemic stroke and is associated with poor outcome. Head circumference may be a tool to alert clinicians to the potential of abnormal neurologic outcome.
Recruitment Process in Salafi-Jihadist Groups in the Middle East (A Qualitative Study)
Authors: Karimi Yusef , Nussbaum David , Mohammadi Razgar
Published: March 2021

Studies on the psychology of terrorism and fundamentalism place great importance on the role of groups, with a central concept of “us” versus “them.” The present study examines how and why Salafi-jihadist groups in the Middle East have attracted typical citizens. The participants in this qualitative study were unremarkable Kurdish people living near the western borders of Iran with an allegiance toward Salafi-jihadist groups. We selected 12 people for the purposes of this study. Findings indicate that “group adaptation” and “rejection of the other” are the two overarching themes pointed out by the participants. Group adaptation included four sub-themes: (a) Idealization of, plus identification and assimilation with the leader, (b) developing strong group bonds, (c) direct and nonhierarchical agency of the individual in the group, and (d) group hypnotic suggestion. The “rejection of the other” included two sub-themes: (a) in-group rejection (reducing legitimate Islam to Salafism) and (b) out-group rejection (rejection of non-Muslims). The results of the study highlight the importance of a sense of belonging to the group in the process of recruitment and assimilation of individuals into jihadist groups. Findings also indicate that the concepts of adaptation and rejection play a pivotal role in the formation of fundamentalist Salafi-jihadist groups and resultant violence. We discuss the implications of group analysis for possible ways to counterterrorism.
Recomposing persons: Scavenging and storytelling in a birth cohort archive
Authors: Tinkler Penny , Cruz Resto , Fenton Laura
Published: March 2021

Birth cohort studies can be used not only to generate population-level quantitative data, but also to recompose persons. The crux is how we understand data and persons. Recomposition entails scavenging for various (including unrecognised) data. It foregrounds the perspective and subjectivity of survey participants, but without forgetting the partiality and incompleteness of the accounts that it may generate. Although interested in the singularity of individuals, it attends to the historical and relational embeddedness of personhood. It examines the multiple and complex temporalities that suffuse people’s lives, hence departing from linear notions of the life course. It implies involvement, as well as reflexivity, on the part of researchers. It embraces the heterogeneity and transformations over time of scientific archives and the interpretive possibilities, as well as incompleteness, of birth cohort studies data. Interested in the unfolding of lives over time, it also shines light on meaningful biographical moments.
Selection of patients for large mailed fecal immunochemical test colorectal cancer screening outreach programs: A systematic review
Authors: Wang Andrew , Lee Briton , Patel Shreya , Whitaker Evans , Issaka Rachel B , Somsouk Ma
Published: March 2021

Objective

Digital health care offers an opportunity to scale and personalize cancer screening programs, such as mailed outreach for colorectal cancer (CRC) screening. However, studies that describe the patient selection strategy and process for CRC screening are limited. Our objective was to evaluate implementation strategies for selecting patients for CRC screening programs in large health care systems.

Methods

We conducted a systematic review of 30 studies along with key informant surveys and interviews to describe programmatic implementation strategies for selecting patients for CRC screening. PubMed and Embase were searched since inception through December 2018, and hand searches were performed of the retrieved reference lists but none were incorporated ( n = 0). No language exclusions were applied.

Results

Common criteria for outreach exclusion included: being up-to-date with routine CRC screening ( n = 22), comorbidities ( n = 20), and personal history ( n = 22) or family history of cancer ( n = 9). Key informant surveys and interviews were performed ( n = 28) to understand data sources and practices for patient outreach selection, and found that 13 studies leveraged electronic medical care records, 10 studies leveraged a population registry (national, municipal, community, health), 4 studies required patient opt-in, and 1 study required primary care provider referral. Broad ranges in fecal immunochemical test completion were observed in community clinic ( n = 8, 31.0–59.6%), integrated health system ( n = 5, 21.2–82.7%), and national regional CRC screening programs ( n = 17, 23.0–64.7%). Six studies used technical codes, and four studies required patient self-reporting from a questionnaire to participate.

Conclusion

This systematic review provides health systems with the diverse outreach practices and technical tools to support efforts to automate patient selection for CRC screening outreach.
Systematic Review of the Long-Term Effects of Presurgical Orthopedic Devices on Patient Outcomes
Authors: Garland Katie , McNeely Brendan , Dubois Luc , Matic Damir
Published: March 2021

Objective:

To perform a systematic review of the literature to identify the long-term effects of presurgical orthopedic (PSO) device use on patient outcomes.

Design:

A comprehensive literature review of Embase and Ovid databases was performed to identify all English-language publications related to unilateral cleft lip and palate, presurgical devices, and patient outcomes. Studies were excluded if they did not report patient outcomes beyond 2 years of age, did not describe the use of a PSO device, were case reports (n < 10), or were purely descriptive studies.

Main Outcome Measures:

Reported patient outcomes following the use of PSO devices.

Results:

Following a review of all articles by 2 independent reviews, 30 articles were selected for inclusion. Overall, there was no reported consensus as to the long-term effects of PSO devices. Furthermore, this study identified that only 10% of published research controlled for confounding factors that could influence the reported results. Confounding factors that were identified included different operating surgeon, different surgical protocols, and different rates of revision surgeries.

Conclusions:

Overall, this systematic review identified 2 important conclusions. Firstly, there is no consensus in the literature about the long-term effects of PSO devices on long-term patient outcomes. Secondly, research in this domain is limited by confounding factors that influence the applicability of the reported results.
An Integrative Definition and Framework to Study Gossip
Authors: Dores Cruz Terence D. , Nieper Annika S. , Testori Martina , Martinescu Elena , Beersma Bianca
Published: March 2021

The omnipresence of workplace gossip makes understanding gossip processes imperative to understand social life in organizations. Although gossip research has recently increased across the social sciences, gossip is conceptualized in disparate ways in the scientific literature. This conceptual confusion impedes theoretical integration and providing practical advice. To resolve this, we systematically reviewed 6114 scientific articles on gossip and identified 324 articles that define gossip. From these definitions, we extracted two essential characteristics of gossip on which there seems to be agreement within the literature, namely, (1) that gossip is communication between humans involving a sender, a receiver, and a target, and (2) that the target is absent or unaware of the communicated content. These two characteristics formed the basis of a broad, integrative definition of gossip: a sender communicating to a receiver about a target who is absent or unaware of the content. Furthermore, some definitions include characteristics on which there is less agreement: gossip valence (from negative to neutral to positive) and formality (from informal to intermediate to formal). We incorporate these characteristics in a dimensional scaling framework that can guide future research. Our broad, integrative definition of gossip and the dimensional scaling framework provide the building blocks for a systematic, integrated knowledge base on the role of gossip in human social life in general as well as in organizations. This can foster future theory development and hypothesis testing, ultimately helping organizations to manage gossip.
Prediction of Drug-Induced Long QT Syndrome Using Machine Learning Applied to Harmonized Electronic Health Record Data
Authors: Simon Steven T. , Mandair Divneet , Tiwari Premanand , Rosenberg Michael A.
Published: March 2021

Background:

Drug-induced QT prolongation is a potentially preventable cause of morbidity and mortality, however there are no widespread clinical tools utilized to predict which individuals are at greatest risk. Machine learning (ML) algorithms may provide a method for identifying these individuals, and could be automated to directly alert providers in real time.

Objective:

This study applies ML techniques to electronic health record (EHR) data to identify an integrated risk-prediction model that can be deployed to predict risk of drug-induced QT prolongation.

Methods:

We examined harmonized data from the UCHealth EHR and identified inpatients who had received a medication known to prolong the QT interval. Using a binary outcome of the development of a QTc interval >500 ms within 24 hours of medication initiation or no ECG with a QTc interval >500 ms, we compared multiple machine learning methods by classification accuracy and performed calibration and rescaling of the final model.

Results:

We identified 35,639 inpatients who received a known QT-prolonging medication and an ECG performed within 24 hours of administration. Of those, 4,558 patients developed a QTc > 500 ms and 31,081 patients did not. A deep neural network with random oversampling of controls was found to provide superior classification accuracy (F1 score 0.404; AUC 0.71) for the development of a long QT interval compared with other methods. The optimal cutpoint for prediction was determined and was reasonably accurate (sensitivity 71%; specificity 73%).

Conclusions:

We found that deep neural networks applied to EHR data provide reasonable prediction of which individuals are most susceptible to drug-induced QT prolongation. Future studies are needed to validate this model in novel EHRs and within the physician order entry system to assess the ability to improve patient safety.
EWSR1-ATF1 Fusion in a Myoepithelial Carcinoma of Soft Tissue With Small Round Cell Morphology: A Potential Diagnostic Pitfall
Authors: Leckey Bruce D , John Ivy , Reyes-Múgica Miguel , Naous Rana
Published: March 2021

Myoepithelial tumors of soft tissue are rare mesenchymal neoplasms that overlap with their salivary gland and skin counterparts at both the histopathologic and molecular levels. EWSR1 gene rearrangements with various fusion partners represent a common genetic event in myoepithelial tumors of soft tissue, whether benign or malignant, and may prove useful as a diagnostic tool in difficult cases. However, the number of diagnostic entities with EWSR1 gene rearrangements has grown considerably in recent years, and there is significant morphologic and immunophenotypic overlap amongst this group, underscoring the importance of fusion testing to detect fusion partners that are characteristic of discrete diagnostic entities. Herein, we report a malignant myoepithelial tumor of soft tissue/myoepithelial carcinoma with an undifferentiated round cell morphology arising in a pediatric patient with a EWSR1-ATF1 gene fusion.
EBV-Positive Plasmacytomas Involving a Nasopharyngeal Angiofibroma in an Adolescent
Authors: Mariani Rachel , King Rebecca L , Liu Huifei
Published: March 2021

We report comprehensive characterization of an unusual collision tumor comprising extramedullary plasmacytomas and nasopharyngeal angiofibroma in a pediatric patient, which has yet to be reported. Histologically, the nasopharyngeal angiofibroma showed typical morphology with a diffuse, dense plasmacytic infiltrate in the stroma. The neoplastic plasma cells showed a spectrum of well-differentiated, plasmablastic, and anaplastic morphology, Epstein-Barr virus encoded RNA (EBER) positivity, and aberrant immunophenotype. Fluorescence in situ hybridization using a plasma cell myeloma targeted panel detected gains of 1q21.3 ( CKS1B, x3), 3q27 ( BCL6, x4), and 11q22.3 ( ATM, x3), but no rearrangement of ALK and MYC. A 50-gene next generation sequencing lymphoma panel failed to detect any pathogenic mutation. Plasmacytoma with EBER positivity and plasmablastic morphology must be distinguished from plasmablastic lymphoma due to different clinical management and prognosis. This case highlights the importance of a thorough pathological evaluation of a mass lesion with synchronous neoplastic processes.
Low concentration atropine combined with orthokeratology in the treatment of axial elongation in children with myopia: A meta-analysis
Authors: Yang Ning , Bai Junxing , Liu Li
Published: March 2021

Objective:

To evaluate the effect of low concentration atropine combined with Orthokeratology (OK) lens compared with the OK lens on the changes of axial length in children with moderate and low myopia by meta-analysis.

Methods:

Databases such as PubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched to collect related studies on atropine combined with the OK lens in the treatment of children with moderate and low myopia. The retrieval time was from the establishment of the database to December 2020. The standardized mean difference (SMD) and its 95% confidence interval (CI) were selected as the effect to analyze the changes of the axial length of the eye axis in children with low and moderate myopia treated with low concentration atropine combined with OK lens.

Results:

A total of eight articles were included in this study. Compared with OK lens treatment, low concentration atropine combined with the OK lens significantly slowed down the axial elongation of low and moderate myopia, SMD = −0.68(95% CI: −0.86–−0.50, p < 0.05). According to the subgroup analysis of treatment time, when the treatment time was less than or equal to 6 months, SMD = −0.63(95% CI: −0.88–−0.37, p < 0.05), when the treatment time was 1 year, SMD = −0.76(95% CI: −1.08–−0.43, p < 0.05), and when the treatment time was 2 years, SMD = −0.69(95% CI: −1.07–−0.31, p < 0.05).

Conclusion:

Low concentration atropine combined with the OK lens is more effective than the OK lens in the treatment of children with low to moderate myopia in reducing axial elongation.
Performance characteristics of an aerostatic journal bearing with partially blocked orifices
Authors: Dal Abdurrahim , Karaçay Tuncay
Published: March 2021

Aerostatic journal bearing applications mainly focus on high-speed precision machining, so predictable and smooth functioning of the system is crucial. Air is supplied to the bearing through a number of orifices and any unevenness in the size of these orifices will affect the performance of the system. The size difference could be due to manufacturing error and/or blockage of the orifice because of foreign materials in the air system. In this study, the performance of an aerostatic bearing with a partially blocked orifice is numerically investigated. Firstly, the airflow in the bearing clearance was modeled with Reynolds equation and this equation was numerically solved with the finite difference and differential transform hybrid method to obtain the pressure distribution. Then, the force and the stiffness are calculated from the pressure distribution for different blockage cases of the orifice and different blockage ratios. The results show that the partial blockage of the orifice significantly changes the performance of the system in a positive or a negative way according to the feeding hole position, and the blockage ratio also affects performance.
The cerebellum and its network: Disrupted static and dynamic functional connectivity patterns and cognitive impairment in multiple sclerosis
Authors: Schoonheim Menno M , Douw Linda , Broeders Tommy AA , Eijlers Anand JC , Meijer Kim A , Geurts Jeroen JG
Published: March 2021

Background:

The impact of cerebellar damage and (dys)function on cognition remains understudied in multiple sclerosis.

Objective:

To assess the cognitive relevance of cerebellar structural damage and functional connectivity (FC) in relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS).

Methods:

This study included 149 patients with early RRMS, 81 late RRMS, 48 SPMS and 82 controls. Cerebellar cortical imaging included fractional anisotropy, grey matter volume and resting-state functional magnetic resonance imaging (MRI). Cerebellar FC was assessed with literature-based resting-state networks, using static connectivity (that is, conventional correlations), and dynamic connectivity (that is, fluctuations in FC strength). Measures were compared between groups and related to disability and cognition.

Results:

Cognitive impairment (CI) and cerebellar damage were worst in SPMS. Only SPMS showed cerebellar connectivity changes, compared to early RRMS and controls. Lower static FC was seen in fronto-parietal and default-mode networks. Higher dynamic FC was seen in dorsal and ventral attention, default-mode and deep grey matter networks. Cerebellar atrophy and higher dynamic FC together explained 32% of disability and 24% of cognitive variance. Higher dynamic FC was related to working and verbal memory and to information processing speed.

Conclusion:

Cerebellar damage and cerebellar connectivity changes were most prominent in SPMS and related to worse CI.
‘Airport People’ in Transformation: Vertical Disintegration and the Reconfiguration of Occupational Belonging in Terminal Work at Helsinki-Vantaa International Airport
Authors: Vieno Atte
Published: March 2021

This article examines the effects of the vertical disintegration of production on airport terminal workers through the theoretical lens of occupational belonging, highlighting themes of sensory and embodied experience, changing dynamics of employment relationships, and new patterns of inclusion and exclusion. The article contributes to efforts to produce nuanced empirical accounts of the dynamics of post-Fordist work, showing how restructuring had the effect of disrupting employment relations and activity rhythms, while nevertheless preserving ‘the airport’ as a symbolic and relational setting in relation to which occupational belonging could be constructed. The article examines how the work of binding people and jobs, previously undertaken by integrated organisations, was taken up by workers themselves through their personal relationships and will to belong. The article highlights the capacity to undertake this work of belonging as a central dynamic of occupational inclusion and exclusion, a capacity which in this empirical context was experienced as being shaped by age and the ability to make use of personal relationships in navigating precarious employment relations. Based on this empirical analysis, the article argues for belonging as a valuable perspective for studies of materiality, symbolic identification and relationality in post-Fordist work.
Bridging the gap between policy and practice: Unpacking the commercial rhetoric of Google for Education
Authors: Carlsson Hanna
Published: March 2021

This paper unpacks the commercial rhetoric of Google for Education. Through the analysis of information published on the official Google for Education website, the paper seeks to make visible how this service promotes and reproduces certain ways of talking, thinking about and doing education. The aim is to contribute to a critical discussion of the potential implications of allowing major commercial players to take the lead in the development of digital infrastructure in education. Guiding the analysis is the notion of ‘problem’ understood as central for Google for Education’s success story. The case of Sweden, in which Google for Education has become widely used, forms the vantage point for this discussion. The study makes visible how Google for Education, in the commercial rhetoric, is constructed as the solution to problem representations by being positioned as a much-needed bridge, in the shape of digital information infrastructure, between digital policy and educational practice. However, Google for Education is far from simply a practical solution to a set of expensive and urgent problems. To uncritically embrace Google as the information infrastructure of education is to hand over power to one actor, which closes doors to alternative paths of doing and knowing in education.
Diary of an assistant professor: Invasion of neoliberal-zombie reform in Polish universities
Authors: Szwabowski Oskar , Gruntkowska Dominika
Published: March 2021

In this article, we use the zombies as a metaphor for reforms in the Polish academy and a description of how neoliberalism works. According to the interpretation of the production of zombies as a critique of late capitalism, we want to show, by using an autoethnographic method, how subjectivity, relationships with others and the world are changing in the neoliberal regime. How do reforms attempt to transform subjectivity, and raise a new academic? Our co-autoethnography challenges the University of the (Un)Dead. We write together to show the experience of an insider (Oskar) and a quasi-outsider (former PhD student, Dominika). We are trying to show how nationalist authoritarianism emerges, at the same time, as part of the neoliberal regime. Our story is a record from the time of the apocalypse – an attempt to provoke. Let us trust the stories.
Sex, Race, Insurance, and Pain: Do Patient Sociodemographics Influence Postoperative Opioid Prescriptions Among Hand Surgeons?
Authors: Peck Connor J. , Carney Martin , Chiu Alexander , Park Kitae E. , Prassinos Alexandre , Allam Omar , Thomson J. Grant , Prsic Adnan
Published: March 2021

Background:

Social and demographic factors may influence patient treatment by physicians. This study analyzes the influence of patient sociodemographics on prescription practices among hand surgeons.

Methods:

We performed a retrospective analysis of all hand surgeries (N = 5278) at a single academic medical center from January 2016 to September 2018. The average morphine milligram equivalent (MME) prescribed following each surgery was calculated and then classified by age, race, sex, type of insurance, and history of substance use or chronic pain. Multivariate linear regression was used to compare MME among groups.

Results:

Overall, patients with a history of substance abuse were prescribed 31.2 MME more than those without ( P < .0001), and patients with a history of chronic pain were prescribed 36.7 MME more than those without ( P < .0001). After adjusting for these variables and the type of procedure performed, women were prescribed 11.2 MME less than men ( P = .0048), and Hispanics were prescribed 16.6 MME more than whites ( P = .0091) overall. Both Hispanic and black patients were also prescribed more than whites following carpal tunnel release (+19.0 and + 20.0 MME, respectively; P < .001). Patients with private insurance were prescribed 24.5 MME more than those with Medicare ( P < .0001), but 25.0 MME less than those with Medicaid ( P < .0001). There were no differences across age groups.

Conclusions:

Numerous sociodemographic factors influenced postoperative opioid prescription among hand surgeons at our institution. These findings highlight the importance of establishing more uniform, evidence-based guidelines for postoperative pain management, which may help minimize subjectivity and prevent the overtreatment or undertreatment of pain in certain patient populations.
Multi-level deep drawing simulations of AA3104 aluminium alloy using crystal plasticity finite element modelling and phenomenological yield function
Authors: Sun Fujia , Liu Ping , Liu Wencheng
Published: March 2021

This paper proposed a hierarchical multi-level model to study the crystallographic texture induced mechanical anisotropy of AA3104-H19 aluminium sheet from mesoscale to continuum scale. In the mesoscale, full-field crystal plasticity finite element method (CPFEM) was used to provide both in-plane and out-of-plane yield stresses and plastic potential points in various deformation modes. In the continuum scale, these materials sampling points were used to determine the parameters of two phenomenological yield functions (Yld2000-2d in plane stress space and Yld2004-18p in 3D stress space) using associated flow rule (AFR) and non-associated flow rule (non-AFR). The results indicate that higher accuracy obtained by Yld2000-2d and Yld2004-18p yield functions associated with non-AFR in comparison with AFR. These phenomenological models were successfully implemented into finite element (FE) code using an explicit integration scheme to simulate sheet metal forming. It is found that the 3D Yld2004-18p model involved with both in-plane and out-of-plane anisotropies is superior to 2D Yld2000-2d model which only accounts for in-plane anisotropy.
Can You Ever Be Too Smart for Your Own Good? Comparing Linear and Nonlinear Effects of Cognitive Ability on Life Outcomes
Authors: Brown Matt I. , Wai Jonathan , Chabris Christopher F.
Published: March 2021

Despite a long-standing expert consensus about the importance of cognitive ability for life outcomes, contrary views continue to proliferate in scholarly and popular literature. This divergence of beliefs presents an obstacle for evidence-based policymaking and decision-making in a variety of settings. One commonly held idea is that greater cognitive ability does not matter or is actually harmful beyond a certain point (sometimes stated as > 100 or 120 IQ points). We empirically tested these notions using data from four longitudinal, representative cohort studies comprising 48,558 participants in the United States and United Kingdom from 1957 to the present. We found that ability measured in youth has a positive association with most occupational, educational, health, and social outcomes later in life. Most effects were characterized by a moderate to strong linear trend or a practically null effect (mean R2 range = .002–.256). Nearly all nonlinear effects were practically insignificant in magnitude (mean incremental R2 = .001) or were not replicated across cohorts or survey waves. We found no support for any downside to higher ability and no evidence for a threshold beyond which greater scores cease to be beneficial. Thus, greater cognitive ability is generally advantageous—and virtually never detrimental.
Saving Science Through Replication Studies
Authors: Edlund John E. , Cuccolo Kelly , Irgens Megan S. , Wagge Jordan R. , Zlokovich Martha S.
Published: March 2021

The scientific enterprise has long been based on the presumption of replication, although scientists have recently become aware of various corruptions of the enterprise that have hurt replicability. In this article, we begin by considering three illustrations of research paradigms that have all been subject to intense scrutiny through replications and theoretical concerns. The three paradigms are one for which the corpus of research points to a real finding, one for which the corpus of research points to a significantly attenuated effect, and one for which the debate is ongoing. We then discuss what scientists can learn—and how science can be improved—through replications more generally. From there, we discuss what we believe needs to be done to improve scientific inquiry with regard to replication moving forward. Finally, we conclude by providing readers with several different approaches to replication and how these approaches progress science. The approaches discussed include multilab replications of many effects, multilab replications of specific effects, adversarial collaborations, and stand-alone applications.
Reliability assessment of stochastic networks with ER connectivity and ER dependency
Authors: Jia Heping , Peng Rui , Liu Dunnan , Li Yanbin , Ding Yi
Published: March 2021

In stochastic networks, nodes usually function dependently and interact with other nodes through connectivity links or dependency links. In this paper, the model for stochastic networks considering sub-networks with connectivity and dependency links of Erdös-Rényi (ER) topology is proposed, which is defined as networks with arbitrary pair of nodes randomly connected/depended by a constant probability. The reliability evaluation framework for the proposed networks is developed, where both of the extended multi-valued decision diagram (MDD) method and Monte Carlo simulation (MCS) are involved. The MDD method is proposed to assess the reliability of deterministic stochastic networks with ER connectivity and dependency, where arbitrary time to failure distributions of nodes are allowed. Based on the reliability evaluation for a stochastic network with a deterministic structure, the MCS is employed to achieve the reliability analysis of corresponding stochastic networks. Numerical examples are presented to demonstrate the proposed stochastic network model and reliability evaluation framework, where the probability distributions for the reliability of stochastic networks are provided.