bluuebunny/crossref_metadata_2025 huggingface dataset:
« J’exerce en moy ces deux utérins frères ». Antéros chez les pétrarquistes français au xvie siècle
Authors: Amiel Gautier
Published: July 2024

À l’imitation de leur modèle italien, les pétrarquistes français chantent les amours douloureuses et désespérées que leur inspire Cupidon ou Éros. Toutefois, on peut également compter sur la présence, discrète mais sensible, d’Antéros pour offrir aux amoureux une voie sentimentale et poétique différente. Petit frère d’Éros, cette divinité ambivalente, qui incarne un idéal de réciprocité amoureuse et punit les mauvais amants, donne naissance au xvie siècle à une nouvelle veine amoureuse qui se tresse à l’écriture pétrarquiste. L’article, à travers une sélection de textes, s’intéresse à la manière dont la poésie guidée par Antéros rencontre la production pétrarquiste. L’antérotisme, pensé comme une érotique et une poétique, apparaît alors comme une manière de jouer avec ou de critiquer les codes de la poésie pétrarquiste et ainsi de remotiver le discours amoureux renaissant.
Atonement de Ian McEwan ou le désir d’expiation d’un écrivain
Authors: Reynier Christine
Published: July 2024

Atonement (2001) se veut être une justification par l’auteur de ses choix esthétiques et une réflexion sur la responsabilité de l’écrivain et son engagement. Cet article se propose de montrer comment le travail de la citation permet au texte de se tisser et de dépasser les simples enjeux du récit. On verra comment l’auteur cite Woolf et comment les deux événements majeurs du roman deviennent l’occasion d’explorer l’esthétique moderniste et de la confronter à celle dont se réclame McEwan. On tentera de montrer comment l’horizon d’attente de cet écrivain-lecteur oriente sa lecture des modernistes ainsi que le débat qu’il entame sur la nécessité de l’engagement de la littérature.
Unveiling the Ethical Social and Legal Dimensions of Artificial Intelligence
Authors: Meena Radha , Choudhary Kumar Mukul
Published: July 2024

The last few years have seen unprecedented growth in AI. Nevertheless, very limited research exists on the effect AI may cause to the human rights and fundamental rights of the individuals. Issues further exist on the role the state may play in determination and protection of rights of the individual. Therefore, in this chapter, the authors show the impact of AI on human rights. The role the state may play in protection of those rights and the best method to regulate the AI are explored. The authors ultimately assert that AI is a beneficial tool and some regulations from the side of the state will protect the fundamental rights of the citizens.
A Study on Exploring the Intersectionality Between India's Data Protection Laws and Consumer Digital Privacy
Authors: Singh Gargi , Sadique Md Zafar
Published: July 2024

The internet's pervasive influence has transformed global financial transactions and reshaped market dynamics. The late 20th-century IT revolution in India gave rise to online-focused IT companies, dominating various aspects of life. The subsequent 4G internet revolution accelerated internet accessibility, fostering the establishment of new technologies and companies enhancing user experiences. E-commerce flourished, with cloud-based entities, reshaping consumer preferences towards online shopping. This paradigm shift comes with challenges. As online transactions surged, data became the cornerstone sought by companies for feedback and analysis. This led to a complex scenario with vast data storage across companies, posing security risks from potential hackers. In the past decade, hacking incidents exposed customer data, risking privacy and well-being. Despite enacted legislation, success, especially in India, remains elusive. This chapter analyzes the nexus between data privacy and E-commerce, conducting an in-depth global study on laws governing data commerce.
The Right to Work in Light of Encroaching Automation
Authors: Danielsson Alicia , Abdel-Haq Mohammed
Published: July 2024

Technologies have revolutionized industries by enhancing operational efficiency, fostering productivity, and creating new job sectors. For example, machine learning algorithms now facilitate predictive maintenance in manufacturing, reducing downtime and optimizing maintenance schedules. Similarly, AI-powered chatbots have revolutionized customer service by offering round-the-clock support, thereby transforming the role of human customer service representatives. Autonomous vehicles represent another breakthrough, poised to disrupt the transportation industry by affecting logistics, trucking, and ride-sharing services. This transformation, however, presents a dual challenge. While it drives economic growth and innovation, it also raises concerns about job displacement, the erosion of traditional employment opportunities, and the widening gap between skilled and unskilled workers. The rapid pace of automation has ignited a crucial debate on the future of work, emphasizing the need to balance technological benefits with their impact on employment and workers' rights.
Quantifying the relationship between uniaxial compressive strength and slake durability index in gneiss rocks: an experimental approach
Authors: Kanagasundaram G. , Dassanayake A.B.N. , Jayawardena C.L. , Chaminda S.P.
Published: July 2024

This study investigated the relationship between Uniaxial Compressive Strength (UCS) and slake durability index (SDI) in gneiss rocks collected from two aggregate quarry sites. The analysis revealed varying correlations between these two parameters depending on the grouping and categorisation of the data. Initially, a moderate correlation was observed between experimental and estimated UCS values when considering all the data together. However, further examination of the data by dividing it into two categories based on UCS values greater than or equal to 40 MPa and less than 40 MPa yielded insightful results. Within these divided categories, a robust correlation was found between experimental and estimated UCS values for cycles two and four of SDI. Moreover, this study reveals that fresh rock samples from the quarry locations maintained a durability of over 98% through four cycles of the slake durability test. Nonetheless, these same samples exhibited decreased strength, which can be attributed to their mineral composition and internal structural arrangements of the rock samples tested. Therefore, this study incorporated complementary testing methods such as Ultrasonic Pulse Wave Velocity (UPV) and Scanning Electron Microscope/Energy Dispersive X-ray Spectroscopy (SEM/EDX). These tests served as valuable tools for validating the results and enhancing the understanding of micro-scale changes within the gneiss rock samples. The comparison of test values and the exploration of underlying factors confirmed the reliability and usefulness of UPV and SEM/EDX as supporting tools for this study. The study also recommended that the developed equations can be useful for engineers and researchers in estimating rock strength quickly and inexpensively by replacing the laborious tasks involved in traditional laboratory testing.
The 'small Greek cities' of the Cape Peninsula
Authors: Van Heyningen Elizabeth B.
Published: July 2024

At the turn of the nineteenth century the numerous small municipalities of the Cape Peninsula were clearly in need of reorganisation. For this reason the Cape Peninsula Commission of 1902 was instituted to investigate the position and make recommendations for improvement. The majority report urged the amalgamation of most of the towns into a single body, while the minority report suggested two smaller corporations. Neither recommendation was adopted, however, for despite their dependence on one another for basic utilities the municipalities clung fiercely to their autonomy and resisted any change.
The old buildings of the Cape
Authors: Oberholster A.G.
Published: July 2024

No abstract available.
The Fort England chapel
Authors: Sampson Sally
Published: July 2024

The story of religious ministry at Fort England is much older than the chapel itself. The Rev. William Shaw held his first local services in the rough army barracks manned by the Hottentot Cape Corps. He conceived the idea of a chapel and Sunday-school for the men on the site, but it was many years before this could be realised. It was not until 1861 that the Methodist Church built the Fort England Chapel just outside the military boundary, primarily for the use of the garrison. When the old fort became an asylum in 1875, the resident chaplain conducted his own services inside the wards; the chapel was out of bounds to patients until 1891, when services began to be held for them there. Eventually, in 1913, the government bought the chapel from the Methodists for £2 000, since when it has served the Fort England Hospital exclusively.
Die mynwerkerstaking Witwatersrand, 1922
Authors: Nöthling F.J.
Published: July 2024

No abstract available.
Bloemfontein - die ontstaan van 'n stad 1846-1946
Authors: Eloff C.C.
Published: July 2024

No abstract available.
Investigating the Involvement of Mediastinal Lymph Nodes in Patients with Papillary Thyroid Carcinoma
Authors: Tabatabaei Sayed Abbas , Kolahdouzan Mohsen , Tabatabaei Sayed Esmaeil
Published: July 2024

Background:

Papillary thyroid carcinoma (PTC) is also the most common endocrine malignancy. In the present study, we aimed to evaluate the metastasis pattern of upper mediastinal lymph node involvement in patients with PTC.

Materials and Methods:

This is a descriptive cross-sectional study that was performed in 2020 in Isfahan, Iran, on 73 patients with PTC who were candidates for total thyroidectomy. Demographic data including age and gender were collected. The frequency distribution of upper mediastinal lymph node involvements and their relationships with mass size, gender, and age, location of tumor in the thyroid gland and involvement of lateral lymph nodes in the neck were evaluated.

Results:

The mean mass size was 17.27 mm. The most involved thyroid lobe in patients with upper mediastinal lymph node involvement was the right lobe (16.5%). In terms of mediastinal lymph node involvement, there were no significant relationships between the two sexes (P = 0.161), primary mass size (P = 0.151), and thyroid mass location (P = 0.739) with mediastinal lymph node involvement. There was a significant relationship between lateral lymph node involvement of the neck (P = 0.007) and age groups (P = 0.042) with involvement of the upper mediastinal lymph nodes. Based on our results, the upper mediastinal lymph node involvement was more frequent among patients under 40 years of age.

Conclusion:

Upper mediastinal lymph node metastasis in PTC was significantly more frequent in cases with younger ages (lower than 40 years) and involvements of lateral lymph nodes in the neck.
MRI Evaluation of Mass-Like and None-Mass-Like-Proven Breast Cancer from Moderate-to-High Background Enhancement
Authors: Farghadani Maryam , Sanei Parinaz
Published: July 2024

Background:

Breast cancer is considered one of the most prevalent cancers among females worldwide. The aim of this study was to assess the magnetic resonance imaging (MRI) patterns of female breast cancer, and also the prevalence of mass-like and nonmass-like lesions among these patients.

Materials and Methods:

32 patients with proven breast cancer (based on their pathologic findings and background parenchymal enhancement [BPE] of their magnetic resonance [MR] images) were included in this cross-sectional study which was performed from 2017 to 2019 in Isfahan, Iran, using a1.5 Tesla (Achieva Philips, Netherland) MRI scanner system. The MR sequences (noncontrast image and at least two contrast-enhanced images) were done in the prone position for studied patients.

Results:

It was found that 68.8% (n = 44) and 31.2% (n = 20) of breast cancers were suffered from moderate and severe BPE, respectively. Furthermore, the prevalence of mass-like nonmass-like and both tumors were 43.8%, 43.8%, and 12.4%, respectively. Pathological studies indicated that 50%, 37.5%, and 12.5% of cancers were ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC), and DCIS, respectively. In addition, a significant relationship between MRI characteristics and pathologic findings was found for IDC and DCIS (P = 0.03).

Conclusion:

Based on the results of this study, the relationship between BPE level and MRI finding including mass-like or nonmass-like lesions in biopsy-proven breast cancers was not significant.
A Longitudinal Study of Acute Diarrhoeal Diseases Among Children Under Five Years in an Urban Area of Goa
Authors: Sawant Apika K , Dhupdale Nitin Y
Published: July 2024

Background:

Acute diarrhoeal diseases (ADD) account for a large number of preventable deaths in India, especially in children less than five years who are more at risk than adults with respect to the degree of dehydration and complications. (1) To measure the incidence of ADD among children under 5 years; (2) Determine risk factors associated among children; (3) Study treatment-seeking behaviour of their mothers. Community-based, prospective, longitudinal study conducted in an urban area of Goa.

Material and Methods:

250 children enrolled in the study with their mothers by stratified random sampling technique, conducted house-to-house visits every three months and mothers were interviewed with pre-tested semi-structured questionnaire. The duration of study was one year from January to December 2018. Data entered using EpiData Entry Client®, Analysed using SPSS® software version 22. Student’s t-tests and Chi-square tests were used.

Results:

The incidence of ADD was 0.124 episodes/child/year. Significant association was noted between ADD in children and certain socio-demographic factors like child’s sex, birth order, birth weight, immunization status, malnutrition, mother’s age group, mother’s education, and mothers’ hygiene practices.

Conclusions:

Efforts should be made to educate all mothers about the seeking timely treatment, awareness about home-based management and their types, awareness of ORS, zinc, importance of hygienic practices like hand washing for mother and child.
Awareness and Attitude of Pregnant Couple Toward Umbilical Cord Blood Banking in Telangana: A Cross-sectional Study
Authors: Anandgaonkar Rohan K. , Motwani Rohini , Ramaswamy Gomathi , Patnaik Nabnita
Published: July 2024

Banking of umbilical cord blood (UCB) is performed to collect and store umbilical cord stem cells. Both public and private cord blood banks have been established around the world. The study aimed to determine the level of awareness of UCB banking among pregnant couples and to assess the attitude of the couples toward UCB banking. We also tried to explore the factors influencing the UCB banking donation and the couple’s expectations of UCB banking in the future. A prevalidated questionnaire on UCB banking was administered, and the interview was conducted among the same pregnant couples (both husband and wife) attending the obstetrics and gynecology (OBG) outpatient department (OPD). Only 28% (N = 121) of the participants had heard of UCB banking, and only 12% had correct knowledge of UCB banking. Only 4.9% of participants had heard of public or private UCB banks. Only one couple of 121 has stored UCB in their previous pregnancy, and about 36% of couples were willing to store their newborn’s UCB in the present pregnancy. Poor understanding continues to be a significant barrier to reaping the benefits of UCB and preservation. Obstetricians and pediatricians should take a more active role in educating patients about the benefits and drawbacks of UCB banking.
Effects of visual neuroplasticity training on visual perception, visual quality, and macular blood flow in patients with strabismus
Authors: Tian Min , Luo Linbi , Zhang Peilin , Cheng Zixuan , Liu Siyan , Zhang Xibo , Wu Jinchuan , Lv Hongbin
Published: July 2024

Purpose:

To observe the effects of visual neuroplasticity training on visual perception, visual quality, and macular blood flow in patients with concomitant strabismus postoperatively.

Methods:

In total, 108 patients underwent binocular strabismus correction operation, and some patients underwent neuroplasticity training. All patients underwent clinical ophthalmic examination, including measurement of best-corrected visual acuity, spherical equivalent, axis length, optical coherence tomography angiography, optical quality analysis system, and visual perception examinations.

Results:

A total of 78 patients received neuroplasticity training for 1 month postoperatively, and 30 patients did not receive training. All patients underwent a visual perception examination preoperatively and at 1 day, 1 week, and 1 month postoperatively. Macular blood flow and visual quality were examined preoperatively and at 1 month postoperatively. Postoperative visual perception was better than preoperative visual perception (P < 0.05). After neuroplasticity training, the visual perception of the trained subjects was better than that of the untrained subjects (P < 0.05), and the blood flow in the macular area of the trained patients was lower than that of the untrained subjects (P < 0.05). The visual quality of the untrained subjects was lower than that of the trained patients (P < 0.05).

Conclusions:

Visual inspection system could accurately evaluate binocular visual perception in patients with concomitant strabismus. After surgical alignment of the strabismus patient, training can stimulate and integrate the formation of stereovision in a short period of time, maintain the visual quality of patients after surgery, and provide conditions for the formation of binocular visual signals and binocular stereovision, but in the short term, it will lead to the decrease of macular blood vessel density and perfusion density. However, the long-term effects of training have not been proven.
Intraocular lens tilt and decentration after primary and delayed implantation in phacovitrectomy for macula-off rhegmatogenous retinal detachment repair
Authors: Li Qingchen , Yang Zhou , Liu Rui
Published: July 2024

Purpose:

To evaluate the tilt and decentration of intraocular lenses (IOLs) in eyes that underwent phacovitrectomy for macula-off rhegmatogenous retinal detachment (RRD) repair.

Methods:

In this retrospective cohort study, 63 patients with macula-off RRD who underwent phacovitrectomy were enrolled and divided into a primary implantation group (group A) and a delayed implantation group (group B) according to the time of IOL implantation. Routine ocular examinations, including optometry, were performed, and the IOL tilt and decentration were measured. Postoperative refractive prediction error and IOL tilt and decentration were compared between the two groups, and the relevant factors of IOL positions were analyzed.

Results:

The mean spherical refractive prediction error (MSE) was − 0.53 ± 0.39 D in group A and − 0.09 ± 0.55 in group B. The mean absolute spherical refractive prediction error (MASE) was 0.61 ± 0.23 D in group A and 0.50 ± 0.22 D in group B. The difference in MSE (t = −3.623, P < 0.05) but not in MASE (t = 1.866, P = 0.067) between the two groups was significant. The mean IOL tilt and mean decentration were 8.54° ±3.65° and 0.55 ± 0.18 mm in group A and 10.62° ±3.29° and 0.66 ± 0.14 mm, respectively, in Group B. Differences in tilt (t = −2.373, P < 0.05) and decentration (t = −2.698, P < 0.05) between the two groups were both significant. In group B, the mean time interval between phacovitrectomy and IOL implantation (TV-I) was 25.2 ± 6.9 weeks, and the absolute values of both IOL tilt and decentration were positively correlated with TV-I.

Conclusion:

In phacovitrectomy for macula-off RRD repair, primary IOL implantation leads to a postoperative myopic shift, while delayed IOL implantation may cause greater IOL tilt and decentration.
Efficacy of adalimumab in noninfectious pediatric uveitis: Analysis of 29 eyes from a tertiary eye care center in India
Authors: Khan Nida , Dutta Majumder Parthopratim , Janarthanan Mahesh , Biswas Jyotirmay
Published: July 2024

Purpose:

To describe the treatment outcomes of adalimumab in noninfectious pediatric uveitis.

Methods:

The electronic medical records of children with noninfectious uveitis were reviewed retrospectively. The visual improvement and ocular inflammation were assessed according to the Standardization of Uveitis Nomenclature criteria before and after treatment with adalimumab.

Results:

Twenty-nine eyes of 16 patients were included. The mean age of children was 9.4 ± 3.8 years. There were eight (50%) males and eight (50%) females. Juvenile idiopathic arthritis was the most common cause of uveitis in these children (N = 10, 62.5%), followed by Behçet’s disease (N = 3, 18.75%) and Vogt–Koyanagi–Harada disease (N = 2, 12.5%). One child (6.25%) was diagnosed with Crohn’s disease. Nine (56.3%) children were previously treated with methotrexate, one each with mycophenolate mofetil (MMF) (6.3%), azathioprine (6.3%), and tofacitinib (6.3%), and one child received MMF followed by azathioprine and cyclosporine before shifting to adalimumab. Three (18.8%) children did not receive prior immunosuppressive therapy. The average number of adalimumab injections given was 20.3 ± 12.0 at an interval of 2 weeks. The mean follow-up duration was 22.2 ± 16.6 months. Disease inactivity was achieved in 28 (96.6%) eyes at last visit (P < 0.001). The best-corrected visual acuity (BCVA) improved from 0.48 ± 0.6 logMAR (logarithm of minimum of resolution) units at baseline to 0.20 ± 0.2 logMAR units at last visit (P = 0.018). Disease remission was achieved in 23 (79.3%) eyes at the third month (P = 0.001).

Conclusion:

Adalimumab is effective in the treatment of pediatric noninfectious uveitis by achieving disease inactivity, reducing the recurrence rate and improving BCVA. The drug is safe and well tolerated.
Development and validation of the Thai version of MNREAD acuity charts
Authors: Leeungurasatien Thidarat , Srinut Songporn , Duenpen Yonlada , Tantraworasin Apichat
Published: July 2024

Purpose:

To develop and validate MNREAD acuity charts in the Thai language (MNREAD-TH).

Methods:

In total, 180 Thai sentences were generated using words specific to the primary 1–3 students. Each sentence contained 60 characters divided into three lines with even left and right margins and was evaluated by instructors in the education program in Thai. The selected 118 sentences were tested in 20 adults and 20 children by measuring reading time and recording the errors. Sentences with extremely high or low mean reading speeds were excluded. The remaining sentences were selected for contributing to the MNREAD-TH charts. For validation, the charts were tested in another 20 normal-sighted adult groups.

Results:

In total, 118 sentences were tested on 20 adults (range: 23–58 years) and 20 primary school students (age: 8–9 years). The mean (SD) reading speeds in adult and children’s groups were 134.09 (12.45) and 71.33 (10.77) words/min (wpm), respectively. After removing the sentences that deviated by ±1 SD from the mean reading speed, repeatedly had difficulty words, and had low subjective scoring, 60 matched sentences between the groups were selected to develop three versions of the MNREAD-TH chart. The intraclass correlation coefficients between charts were 0.85 for reading acuity, 0.94 for maximum reading speed, and 0.79 for critical print size.

Conclusion:

The MNREAD-TH charts can be reliably used for evaluating reading performance in Thai people for both children and adults with either normal sight or low vision. These charts are standardized and helpful in clinical trials involving reading.
Efficacy of dexamethasone implant in the management of chronic central serous chorioretinopathy without choroidal neovascularization
Authors: Behera Umesh Chandra , Brar Anand S , Kelgaonkar Anup , Sahoo Jyotiranjan , Narayanan Raja , Sadda SriniVas R
Published: July 2024

Purpose:

To demonstrate the treatment efficacy of intravitreal dexamethasone (DEX) implant in chronic recurrent/persistent central serous chorioretinopathy (CSC).

Design:

Prospective, non-randomized, open-label study.

Methods:

In this study, subjects with chronic CSC without signs of choroidal neovascularization (CNV) received intravitreal DEX implant therapy. The primary outcome measure was the change in visual acuity. Changes in central macular thickness (CMT) and change in subfoveal choroidal thickness (SFCT) on optical coherence tomography (OCT), incidence of recurrent fluid, and safety of DEX implant were secondary outcome measures. Subjects were followed up for a minimum of 3 months after DEX implantation.

Results:

In total, 20 eyes of 20 subjects (mean age: 47 ± 9 years) with a median disease duration of 23.5 months were enrolled. With a single injection of DEX implant, a reduction in CMT was noted in 90% of eyes. Complete resolution of subretinal and intraretinal fluid was noted in 55% of eyes within 3 months of injection. A significant improvement in vision (mean Log MAR visual acuity: 0.66 ± 0.49 vs. 0.54 ± 0.45; P = 0.020), mean CMT (338 ± 110 microns to 238 ± 73 microns; P < 0.001) and SFCT (514 ± 95 microns to 445 ± 111 microns; P < 0.001) was noted over 3 months. Recurrent fluid was noted in 50% of eyes after a mean follow-up duration of 7 ± 4 months. Elevated intraocular pressure, managed by topical therapy, was noted in six eyes.

Conclusion:

The consistent improvement in visual acuity, fluid resolution, and reduction in choroidal thickness suggests a possible role for DEX implants in managing chronic CSC. A larger randomized trial is warranted.
Is Partial ACL Tear a Cause of Painful Swollen Knees?
Authors: Bakr Hany Mohammed Abdelfattah , Abdelkader Salah Mahmoud , Safwat Yamen
Published: July 2024

Study Design:

Retrospective case series.

Objective:

In this study, we will identify if partial ACL tear is a common hidden cause of chronic pain and swelling of the knee in adults. And we will evaluate the effectiveness of arthroscopic selective bundle reconstruction in the management of this condition.

Background:

The Anterior Cruciate Ligament (ACL) has two anatomical bundles, the anteromedial (AM) and the posterolateral (PL), each bundle was named according to the site of its tibial insertion.[1] Partial ACL tear is evident and symptomatic when the percentage of the torn fibers is more than 50% of ligament fibers. AM bundle is more liable to injury than PL.[2] Symptomps of partial ACL tear may be giving way and instability but persistent knee pain and swelling is often present as the main presenting symptom of the patient due to micro-instability of the knee, The primary complication of longstanding partial ACL tears is early knee degeneration.[3]

Patients and Methods:

37 patients with chronic knee pain and swelling, related to activity and resistant to non-operative treatment, underwent diagnostic knee arthroscopy. In 3 cases diagnostic arthroscopy revealed osteochondral ulcers of the medial compartment of the knee managed by drilling and 4 cases showed non-specific synovitis managed by arthroscopic synovectomy. 30 of these patients, who were included in this study, were found to suffer from partial ACL tear and underwent single bundle reconstruction, 18 of them underwent selective AM bundle reconstruction while preserving PL bundle. Twelve patients underwent selective PL bundle reconstruction with AM bundle preservation. Semitendinosus tendon graft was utilized for all reconstructions. The femoral side was always fixed with an adjustable loop (Zimmer), and the tibial side with a biodegradable interference screw. Lysholm score[4] was used to assess the outcomes. Patients with severe degenerative disorders, lower limb mal-alignment and multiple ligamentous injuries of the knee were excluded from our study.

Results:

Marked decrease in the knee pain and swelling postoperatively. The preoperative score had a mean value of 66.17±10.39. At 2 years, the postoperative score was 96.1±6.71, indicating a highly statistically significant improvement (P value 0.001).

Hypothesis:

Partial ACL tears are the commonest hidden cause of pain and swelling of the knee among young adults.

Conclusion:

Arthroscopic selective bundle reconstruction diminishes knee pain and swelling with a very satisfactory postoperative clinical outcomes.
An enigmatic combined tumour of oral malignant melanoma and oral squamous cell carcinoma – A rare case report
Authors: Renuga S , Sahana NS , Suganya G , Kulkarni Meghashyama
Published: July 2024

Combined tumours are those composed of two benign tumours or a benign and malignant tumour or two malignant tumours occurring within the same tumour population. The incidence of combined tumours is very rare. Due to the rarity of these tumours, their biological behaviour remains unlashed. Incisional biopsy of a 48 years old female patient with single, diffuse tumour mass in the oral cavity showed combined tumour or collision tumour of malignant melanoma and squamous cell carcinoma. This was confirmed with immunohistochemistry study. The incidence of combined tumour of malignant melanoma and squamous cell carcinoma in oral cavity is extremely rare. To the best of our knowledge based on the previous literature records, this is the first case report of its kind where there is incidence in the human oral cavity.
Paediatric oral hyaline ring granuloma associated with an impacted tooth and its management preserving the tooth germ: A case report
Authors: Deo Jaspreet Kaur , Mehra Pravesh , Shukla Shailaja
Published: July 2024

Oral hyaline ring granuloma is an unusual granulomatous lesion affecting the jaws characterized by the presence of numerous eosinophilic rings with multinucleated giant cells. The lesion can be of central or peripheral variety, caused by the impaction of foreign particles in the oral cavity. While literature describes this lesion in association with dentures, carious teeth and extraction socket, this paper reports the first case of an oral hyaline ring granuloma associated with an impacted premolar tooth and its surgical management.
A systematic review on odontogenic cysts and tumours
Authors: Singh Harkanwal P. , Chahal Gagandeep K. , Sharma Geeta , Gandhi Piyush
Published: July 2024

Background:

There are still certain gaps in the research that need to be filled despite the fact that numerous studies have looked into the transformation of odontogenic cysts into neoplastic lesions. To identify pertinent research that had been published and to synthesise the available data and provide an overview of the current body of knowledge, this review also sought to do so.

Materials and Methods:

Adopting the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a search strategy was implemented across several online databases to search for relevant articles as per the defined selection criterion.

Results:

After the search strategy was complete, 31 studies were chosen. Men tended to have more cancer than women. Swelling and discomfort were the primary pathology-related complaints. Although two cases were not detailed, radiologically, well-defined and poorly defined borders were reported in 18 and 11 participants, respectively. Squamous cell carcinoma with good differentiation (n = 12) was the most common cancer kind. More than 74% of patients were still living 6 months to 10 years following follow-up, four (12.90%) experienced recurrences and/or metastases and two (6.45%) experienced a disease-related mortality between 2 months and a year.

Conclusion:

Prompt surgical follow-ups and cautious excision of odontogenic cysts are essential to avoiding neoplastic change and recurrence. Future research is required to look at possible reasons why odontogenic cysts can convert neoplastically.
Salivary α-amylase as a stress biomarker in mentally and physically disabled individuals during COVID-19 times
Authors: Gaurav Ashish , Sharma Gaganjot Kaur , Chhabra Ajay , Bamba Sakshi , Sahoo Sabashish , Chhabra Vandana
Published: July 2024

Background:

Stress is faced by every individual in their day-to-day life activities. During pandemic, most people have experienced multiple episodes of depression, anxiety, and insomnia. Several medical and dental problems are reported with stress and the fastest and easiest way to study and investigate is through body fluids, mainly saliva. Hence, we aim to study salivary α amylase in disabled individuals and hypothesize that salivary α amylase could be a reliable stress biomarker in disabled individuals.

Materials and Methods:

Cross-sectional study was conducted including 200 individuals grouped into controls (100) and disabled individuals (100). Disabled individuals were further grouped into physically (50) and mentally (50) disabled. Stimulated and unstimulated saliva was collected from all the participants and were investigated for salivary α-amylase by direct substrate method. The enzyme activity was analyzed using a spectrophotometer and the obtained were analyzed statistically.

Result:

Salivary α-amylase showed significant difference between controls and disabled group (p = 0.000). Salivary α-amylase was least in the mentally disabled group compared to physically disabled group. Age related comparison of salivary α-amylase was higher in physically disabled whereas gender related comparison showed females in physically disabled group to be more affected than controls.

Conclusion:

Saliva, the easy and most researched fluid, is rich in salivary α-amylase. Salivary α-amylase is a potential biomarker to assess stress. Further diagnostic studies are required to know the salivary changes and their influence on individual general health status.
Auto imputation enabled deep Temporal Convolutional Network (TCN) model for pm2.5 forecasting
Authors: Samal K. Krishna Rani
Published: July 2024

Data imputation of missing values is one of the critical issues for data engineering, such as air quality modeling. It is challenging to handle missing pollutant values because they are collected at irregular and different times. Accurate estimation of those missing values is critical for the air pollution prediction task. Effective forecasting is a significant part of air quality modeling for a robust early warning system. This study developed a neural network model, a Temporal Convolutional Network (TCN) with an imputation block (TCN-I), to simultaneously perform data imputation and forecasting tasks. As pollution sensor data suffer from different types of missing values whose causes are varied, TCN is attempted to impute those missing values in this study and perform prediction tasks in a single model. The results prove that the TCN-I model outperforms the baseline models.
Integrated Transcriptomic Landscape and Deep Learning Based Survival Prediction in Uterine Sarcomas
Authors: Song Yaolin , Li Guangqi , Zhang Zhenqi , Liu Yinbo , Jia Huiqing , Zhang Chao , Wang Jigang , Hu Yanjiao , Hao Fengyun , Liu Xianglan , Xie Yunxia , Ma Ding , Li Ganghua , Tai Zaixian , Xing Xiaoming
Published: July 2024

Purpose The genomic characteristics of uterine sarcomas have not been fully elucidated. This study aimed to explore the genomic landscape of the uterine sarcomas (USs).Materials and Methods Comprehensive genomic analysis through RNA-sequencing was conducted. Gene fusion, differentially expressed genes (DEGs), signaling pathway enrichment, immune cell infiltration, and prognosis were analyzed. A deep learning model was constructed to predict the survival of US patients.Results A total of 71 US samples were examined, including 47 endometrial stromal sarcomas (ESS), 18 uterine leiomyosarcomas (uLMS), three adenosarcomas, two carcinosarcomas, and one uterine tumor resembling an ovarian sex-cord tumor. ESS (including high-grade ESS [HGESS] and low-grade ESS [LGESS]) and uLMS showed distinct gene fusion signatures; a novel gene fusion site, MRPS18A–PDC-AS1 could be a potential diagnostic marker for the pathology differential diagnosis of uLMS and ESS; 797 and 477 uterine sarcoma DEGs (uDEGs) were identified in the ESS vs. uLMS and HGESS vs. LGESS groups, respectively. The uDEGs were enriched in multiple pathways. Fifteen genes including LAMB4 were confirmed with prognostic value in USs; immune infiltration analysis revealed the prognositic value of myeloid dendritic cells, plasmacytoid dendritic cells, natural killer cells, macrophage M1, monocytes and hematopoietic stem cells in USs; the deep learning model named Max-Mean Non-Local multi-instance learning (MMN-MIL) showed satisfactory performance in predicting the survival of US patients, with the area under the receiver operating curve curve reached 0.909 and accuracy achieved 0.804.Conclusion USs harbored distinct gene fusion characteristics and gene expression features between HGESS, LGESS, and uLMS. The MMN-MIL model could effectively predict the survival of US patients.
Self-similarity and limit spaces of substitution tiling semigroups
Authors: Walton James , Whittaker Michael F.
Published: July 2024

We show that Kellendonk’s tiling semigroup of a finite local complexity substitution tiling is self-similar, in the sense of Bartholdi, Grigorchuk and Nekrashevych. We extend the notion of the limit space of a self-similar group to the setting of self-similar semigroups, and show that it is homeomorphic to the Anderson–Putnam complex for such substitution tilings, with natural self-map induced by the substitution. Thus, the inverse limit of the limit space, given by the limit solenoid of the self-similar semigroup, is homeomorphic to the translational hull of the tiling.
Singularities of the network flow with symmetric initial data
Authors: Novaga Matteo , Sciaraffia Luciano
Published: July 2024

We study the formation of singularities for the curvature flow of networks when the initial data is symmetric with respect to a pair of perpendicular axes and has two triple junctions. We show that, in this case, the set of singular times is finite.
Investigación antropológica forense para casos de desaparición forzada: Rol del criminalista en formación de universidades de Tamaulipas y Antioquia
Authors: Zapata-Nieto Marcela , Restrepo-Hernández Natalia Andrea , Villarreal-Sotelo Karla , Gil-Villa Aura María
Published: July 2024

La desaparición forzada representa una problemática de índole mundial que ha afectado a diferentes países de América Latina, entre ellos a México y Colombia, que ha obligado a buscar diferentes estrategias desde la academia y la pedagogía con el fin de formar profesionales idóneos y capacitados, que enfrenten de manera acertada la investigación de este delito.
Esta investigación tuvo como finalidad, revisar las competencias de los estudiantes en formación que como egresados integrarán equipos multidisciplinares en investigaciones antropológicas en casos de desaparición forzada, que pueden hacer parte de los equipos multidisciplinarios de ciencias forenses; identificar las competencias mínimas requeridas desde la investigación Antropológica Forense para la investigación de casos de personas desaparecidas, con lo cual se planea proponer el diseño de una herramienta virtual tipo simular en las instituciones de nivel superior, que refuerce el conocimiento de nuestros estudiantes desde diferentes estrategias pedagógicas y propenda por una formación que esté actualizando y avanzando según las necesidades de la sociedad.
La experiencia política de un grupo de vecinos del Barrio Pila del Ganso, comuna de Estación Central
Authors: Zambra Rafaela
Published: July 2024

En el Barrio Pila del Ganso en la comuna de Estación Central, ciudad de Santiago, hay vecinos y vecinas que resienten el “choc” del cambio abrupto de una vida vecinal y barrial que es valorada. Producto de esta perturbación del curso de la existencia, un grupo de vecinos decide organizarse el año 2014 con el objetivo de defender su barrio contra un intenso proceso de verticalización. El presente artículo tiene por objetivo analizar el desarrollo de esta experiencia, poniendo de relieve su dimensión afectiva y moral, así como también, su carácter ambivalente y contradictorio; dimensiones que han tendido a ser ignoradas en los estudios de movimientos urbanos en Chile. Enfocándonos específicamente en los procesos de politización, el artículo busca ahondar en la manera en cómo los vecinos movilizan la figura de vecino en medio de complejos procesos y sucesos cotidianos que los empujan, a veces, en direcciones contradictorias.
Baitouweng decoction suppresses growth of esophageal carcinoma cells through miR-495-3p/BUB1/STAT3 axis
Authors: Yang Hui , Chen Xiao-Wei , Song Xue-Jie , Du Hai-Yang , Si Fu-Chun
Published: July 2024

BACKGROUND

Esophageal carcinoma (EC) is one of the most prevalent cancers in human populations worldwide. Baitouweng decoction is one of the most important Chinese medicine formulas, with the potential to treat cancer.

AIM

To investigate the role and mechanism of Baitouweng decoction on EC cells.

METHODS

Differentially expressed genes (DEGs) in EC tissues and normal tissues were screened by the cDNA microarray technique and by bioinformatics methods. The target genes of microRNAs were predicted based on the TargetScan database and verified by dual luciferase gene reporter assay. We used Baitouweng decoction to intervene EC cells, and detected the activity of EC9706 and KYSE150 cells by the MTT method. Cell cycle and apoptosis were measured by flow cytometry. The expression of BUB1 mRNA and miR-495-3p was measured by qRT-PCR. The protein levels of BUB1, STAT3, p-STAT3, CCNB1, CDK1, Bax, Caspase3, and Caspase9 were measured by Western blot analysis. The migration and invasion abilities of the cells were measured by wound-healing assay and Transwell invasion assay, respectively.

RESULTS

DEGs identified are involved in biological processes, signaling pathways, and network construction, which are mainly related to mitosis. BUB1 was the key hub gene, and it is also a target gene of miR-495-3p. Baitouweng decoction could upregulate miR-495-3p and inhibit BUB1 expression. In vitro experiments showed that Baitouweng decoction significantly inhibited the migration and invasion of EC cells and induced apoptosis and G2/M phase arrest. After treatment with Baitouweng decoction, the expression of Bax, Caspase 3, and Caspase 9 in EC cells increased significantly, while the expression of BUB1, CCNB1, and CDK1 decreased significantly. Moreover, the STAT3 signaling pathway may play an important role in this process.

CONCLUSION

Baitouweng decoction has a significant inhibitory effect on EC cell growth. BUB1 is a potential therapeutic target for EC. Further analysis showed that Baitouweng decoction may inhibit the growth of EC cells by upregulating miR-495-3p targeting the BUB1-mediated STAT3 signal pathway.
Canopy FGF signaling regulator 3 affects prognosis, immune infiltration, and PI3K/AKT pathway in colon adenocarcinoma
Authors: Gao Xu-Can , Zhou Biao-Huan , Ji Zhou-Xin , Li Qiang , Liu Hui-Ning
Published: July 2024

BACKGROUND

Colon adenocarcinoma (COAD) is a malignant tumor of the digestive system. The mechanisms underlying COAD development and progression are still largely unknown.

AIM

To identify the role of canopy FGF signaling regulator 3 (CNPY3) in the development and progression of COAD by using bioinformatic tools and functional experiments.

METHODS

Bioinformatic data were downloaded from public databases. The associations of clinicopathological features, survival, and immune function with the expression of CNPY3 were analyzed. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses and Gene Set Enrichment Analysis were used to explore the related pathways. Then, quantitative real-time PCR and immunohistochemistry were used for validation of CNPY3 expression in clinical samples and tumor cell lines. Cell lines with CNPY3 knockdown were constructed to further analyze gene functions. The functional experiments included proliferation, invasion, migration and apoptosis assays.

RESULTS

In both the TCGA cohort and the merged dataset, elevated CNPY3 expression was observed in tumor tissues. High CNPY3 expression correlated with adverse survival and compromised immune functions. Functional enrichment analysis suggested that the pro-oncogenic properties of CNPY3 might be linked to the PI3K-AKT signaling pathway. CNPY3 expression was validated at both the RNA and protein levels. Functional assays indicated that cell proliferation, invasion, and migration were inhibited and cell apoptosis was promoted after CNPY3 knockdown. Additionally, Western blot results revealed the downregulation of key proteins in the PI3K/AKT pathway following CNPY3 knockdown. PI3K/AKT pathway activator reversed the decrease in proliferation, invasion, and migration and the increase in apoptosis. Notably, CNPY3 knockdown still affected the cells when the pathway was inhibited.

CONCLUSION

This study showed that CNPY3 is upregulated in COAD and might regulate COAD development and progression by the PI3K/AKT pathway. Thus, CNPY3 might be a promising therapeutic target.
Ghanaian Institutions and Supply Chain Management Practices: A Systematic Review of Evidence
Authors: Ayam Justice Ray Achoanya
Published: July 2024

This systematic review aims to enhance the current understanding of supply chain management (SCM) practices in Ghana by examining emerging trends in the literature. The analysis considered 43 peerreviewed articles published in the last 20 years to identify the features, SCM components, research types, methodologies, and contributions to SCM theory. The results indicate that previous research on SCM practices in Ghana has mainly focused on particular attributes, such as supply chain (SC) risk planning and management, communication and information sharing, quality, strategic supplier partnership, inventory, and logistics management. However, benchmarking, customer relationship, and demand forecast, were list examined. Additionally, research on SCM practices has been concentrated in industries, such as manufacturing, banking and finance, agriculture value chain, health and allied areas, and retail and SMEs. The study also reveals that while quantitative research methods have gained increasing interest, qualitative research methods are still prevalent in the field. The results further highlighted a variety of SCM theories, namely resource-based view, transaction cost theory, agency, SC operations reference (SCOR), network theory, diffusion of innovation theory, contingency theory, and service demand logic, are focal areas of understanding SCM practices, performance, and their critical success factors in Ghanaian industries. This study provides practical insights for industry practitioners to better understand SCM deployment, design, and implementation steps, as well as suggestions for future research directions for SCM theory and practice in Ghana. These include exploring other areas and industries to gain a more comprehensive understanding of SCM practices in the country.
Reimagining Tertiary Education: Issues, Challenges And Solutions
Authors: Uduak Imo Ekpoh , Ovat Egbe Okpa , Terfa Swem
Published: July 2024

Tertiary education in Nigeria is in crisis that requires urgent attention. The reason for this crisis is the failure to appreciate and come to terms with the fact that education is fundamental to national development. Thus, stakeholders in education have come to a consensus that there is a need to save the tertiary education sector from imminent collapse. Hence, the need to reimagine the tertiary education sector by setting the conditions whereby it can perform at its best and compete globally. This paper on reimagining tertiary education: Issues, challenges and solutions have as its main thrust: the meaning of tertiary education, the historical development of tertiary education, the goals of tertiary education, the importance of tertiary education, the needs of tertiary education in Nigeria, issues confronting tertiary education, challenges and possible solutions to issues and challenges of tertiary education in Nigeria. These sub-headings provided the direction for this paper.