bluuebunny/crossref_metadata_2025 huggingface dataset:
The combination of very-small size proteoliposomes and alum is a safe adjuvant alternative for inducing anti-EGF antibodies: a preclinical study
Authors: Mabel Cruz Rodríguez , Gretchen Bergado Báez , Yerandy Hechevarría Luna , Diana Rosa Hernández Fernández , Addys González Palomo , Narjara González Suárez , Carlos Yordan González Castillo , María del Carmen Luzardo Lorenzo , Lisset Chao García , Belinda Sánchez Ramírez
Published: September 2022

Immunization with human recombinant EGF chemically bound to the P64k protein of Neisseria meningitides (hrEGF-P64k) and adjuvanted in Montanide ISA 51 VG (Montanide) is an efficient strategy to induce polyclonal antibodies (PAbs) response targeting this self -antigen in cancer patients, which is the basis of the CIMAvax-EGF vaccine. The neutralizing potential of EGF-specific induced PAbs supports promising clinical data obtained to date with this vaccine. Herein, we evaluated a combination of very small-size proteoliposomes (VSSP) and aluminum hydroxide (Alum) as a novel adjuvant to induce specific PAbs with neutralizing and anti-proliferative properties on tumor cells, considering EGF as a model antigen. Toxicity at the injection site was not detected for the vaccine formulation containing VSSP/Alum, and it was immunogenic in BALB/c mice, as evidenced by the induction of high titers of EGF-specific polyclonal antibodies (PAbs). While schedule optimization increased the magnitude of the PAbs response induced by VSSP/Alum, induced PAbs’s avidity and intrinsic neutralizing potential were comparable to the humoral response induced by Montanide. Also, VSSP addition switched IgG subclasses distribution into a Th1-like pattern, as obtained with Montanide and desirable for a cancer vaccine. Finally, equivalent PAbs titers were induced by the vaccine formulations adjuvanted in VSSP/Alum or Montanide in tumor-bearing-mice, and immunosuppressed mice, suggesting the feasibility of the VSSP/Alum combined adjuvant for inducing anti-EGF antibodies in cancer patients at advanced stages of the disease.
A longitudinal analysis of MPOWER implementation, 2008-2018
Authors: Hagen Les , Heydari Gholamreza , Hammal Fadi
Published: September 2022

Background

In 2008, the World Health Organization (WHO) introduced MPOWER-a package of evidence-based, high-impact policy measures to help countries reduce tobacco use. These measures align with selected articles within the World Health Organization’s Framework Convention on Tobacco Control (FCTC), a global public health treaty to prevent and reduce tobacco use.

Methods

Observational longitudinal study involving 195 countries that submitted biannual national reports between 2008 and 2018. To report changes in MPOWER scores, countries were assessed using a validated checklist of the seven MPOWER indicators and a maximum possible unweighted composite score of 34 points. Covariate analysis was conducted among selected health, sociopolitical, and economic indicators.

Results

176 out of 195 countries improved their MPOWER scores between 2008 and 2018, with two achieving full implementation (Brazil and Turkey). Twenty-three (23) countries representing 11.2% of the global population recorded an MPOWER scoring increase of at least 10 points between 2008 and 2018. The overall mean 10-year scoring increase was 5.1 points or a relative improvement of 27.1%. In 2018, 20 countries representing 10.4% of the global population excelled in MPOWER implementation by receiving a total composite score of at least 30 of 34 possible points. The MPOWER elements with the highest degree of implementation in 2018 include Warn (package), Protect (smoking ban) and Enforce (ad ban). Several covariates were positively associated with higher levels of MPOWER implementation, including cigarette affordability, the existence of national tobacco control objectives, the human development index score, the national corruption index score, national literacy rates and the political regime index score.

Conclusions

MPOWER implementation increased markedly between 2008 and 2018 in all seven WHO regions and countries representing all four World Bank income classifications. However, only two countries achieved full implementation by 2018. More work is needed to improve MPOWER implementation. Countries with low-income levels, compromised human development, reduced literacy rates, higher rates of corruption, and autocratic political regimes appear to struggle more with MPOWER implementation.
Pivoting during the pandemic: adapting research priorities to address community engagement with COVID-19 in Western Kenya
Authors: Ogola Evance , Pande Elias Owour , Dusek Alex , Singaraju Marali , Odhiambo John , Mattah Brian , Karan Samwel , Marshall David , Atieno Scholarstica , Vigneswari Anebarassou Ananda , Elsayed Neamatallah , Chikamai Lavinah , Carlson Aimee , Muldoon Lily , Wilsey David , Ndunyu Louisa , Salmen Charles
Published: September 2022

Among the many profound disruptions created by COVID-19 around the world, the pandemic has greatly tested community-based research endeavours that rely upon international collaboration and face-to-face interactions in rural communities. Our group of Kenyan and American investigators based on remote Mfangano Island on Lake Victoria experienced numerous challenges due to travel restrictions, safety guidelines, and funding interruptions, forcing us to rapidly adapt objectives as conditions evolved in real time. Here we describe our effort to adjust the priorities of the MOMENTUM study, a longitudinal maternal health study, to support a community-driven response to the initial COVID-19 surge in 2020 and the subsequent Delta wave in 2021. Through a dynamic participatory process, our group identified and implemented three COVID-19 engagement strategies including, (i) printed COVID-19 factsheets for local distribution, (ii) vernacular radio programming on a popular local radio station, and (iii) targeted COVID-19 vaccine promotion among key community opinion leaders. We provide a review of the strengths, challenges, and local perspectives regarding these strategies. Due to notable limitations, such as our inability to compare outcomes with similar control populations, and the nature of the specific strategies designed to address the unique needs of these island populations, this report is not intended to provide definitive or generalizable conclusions regarding the impact of a COVID-19 intervention. We present our experience as an illustrative example of how community-based research collaborations can utilize their embedded networks to develop adaptive responses to unexpected public health threats. Most notably, the transition to virtual collaboration facilitated a long-overdue recentering of operational and strategic leadership into the hands of our Kenyan team. This aligned reality on the ground with our long-stated rhetoric regarding North-South equity in design and implementation. Ultimately, our experience in Kenya suggests that amid ongoing disruptions created by a pandemic, there exists both a responsibility to respond to evolving community needs and an opportunity to remodel global health partnerships for improved equity and long-term impact.
Ontology Data Modeling of Indonesian Medicinal Plants and Efficacy
Authors: Afifa Rizky Maulidya , Kusuma Wisnu Ananta , Annisa Annisa
Published: September 2022

People use medicinal plants for as early prevention and treating disease. Medicinal plants must be careful not to cause side effects, so knowledge is needed. Medicinal plant knowledge is stored using an ontology data model. In some ontology studies, there are still shortcomings in managing information, namely the absence of a relationship between scientific terms related to medicinal plants and phrases already known to the public. Hence, it is necessary to have this relationship. In other studies, there is no information related to disease protein, so this research also develops ontologies to enrich knowledge about medicinal plants and their efficacy. Based on the results, the developed ontology test can build a relationship between scientific terms of therapeutic pants and phrases that are known to the public. The public also knows which proteins affect a disease, so public knowledge about medicinal plants is getting wider.
Similarity Identification Based on Word Trigrams Using Exact String Matching Algorithms
Authors: Fadlil Abdul , Sunardi Sunardi , Ramdhani Rezki
Published: September 2022

Several studies regarding excellent exact string matching algorithms can be used to identify similarity, including the Rabin-Karp, Winnowing, and Horspool Boyer-Moore algorithms. In determining similarities, the Rabin-Karp and Winnowing algorithms use fingerprints, while the Horspool Boyer-Moore algorithm uses a bad-character table. However, previous research focused on identifying similarities using these algorithms based on character n-gram. In contrast, identification based on the word n-gram to determine the similarity based on its linguistic meaning, especially for longer strings, had not been covered yet. Therefore, a word-level trigram was proposed to identify similarities based on the word trigrams using the three algorithms and compare each performance. Based on precision, recall, and running time comparison, the Rabin-Karp algorithm results were 100%, 100%, and 0.19 ms, respectively; the Winnowing algorithm results with the smallest window were 100%, 56%, and 0.18 ms, respectively; and the Horspool algorithm results were 100%, 100%, and 0.06 ms. From these results, it can be concluded that the performance of the Horspool Boyer-Moore algorithm is better in terms of precision, recall, and running time.
DESIGN OF ROV STRAIGHT MOTION CONTROL USING PROPORTIONAL SLIDING MODE CONTROL METHOD
Authors: Yudianto Firman , Herlambang Teguh , Susanto Fajar Annas , Suryowinoto Andy , Tomasouw Berny Pebo
Published: September 2022

The development of underwater defense technology is commonly related to its usage for security and defense of a country. The need of NKRI (the Republic of Indonesia) for an applicable and multifunctional technology for highly improved unmanned submarines is urgent considering the current necessity of unmanned technology modernization functioning as The Main Weapon System Equipments (ALUTSISTA) to be applied as a spy technology or automatic weapon. This paper focus is on a motion control system design with the motion equation of 2 Degree of Freedom (DOF) applied to an unmanned submarine system or also called a Remote Operated Vehicle (ROV). ROV requires a control system to control its maneuvering motion when underwater, especially in a straight line motion. The ROV motion equation of 2-DOF consisting of surge and roll motions is in the form of a nonlinear equation. The system control design applied to the ROV system used the Proportional Controller method combined with Sliding Mode Control. The simulation results of the Proportional SMC control system with the motion equation of 2-DOF on the ROV system show that the system is stable with an accuracy of surge and roll motions of 95% - 99%.
Downhole Detection and Geological Prediction of Halite Cement
Authors:   Consultant, Bootle Richard , Moss Adam ,   AKM Geoconsulting Ltd, Omma Jenny ,   Rockytpe
Published: September 2022

The presence of halite cement is a little appreciated problem in petrophysical interpretation. Yet halite is common as a late diagenetic cementing phase associated with high salinity formation water and is recognized in many of the world’s major petroleum basins. Undetected halite cement leads to a significant overestimation of porosity and permeability during petrophysical interpretation. However, halite cement does not have a unique signature on electric logs and is often not represented in core samples. Current best logging practices are inadequate for the quantification of halite cement. Open hole sigma is a recommended logging solution. Scanning Electron Microscopy with Energy Dispersive Spectroscopy can detect halite. This is a rock imaging technique, performed on either cuttings or core. The images can distinguish between layered depositional halite and pore-filling diagenetic halite cement. Occurrences of non-authigenic halite, precipitated as the rock sample is brought to the surface, have a high surface area and are easily removed by sample cleaning. Conventional core analysis can both identify and quantify halite cement. However standard core cleaning methods operate on the premise that all halite is non-authigenic and thus intentionally remove it. Best practice core handling, processing and testing protocols must be followed and, because halite cement is commonly patchy and discontinuous, the core cleaning and drying study must comprise a large number of plugs. Oil-based mud must be used to cut the core. The effects on porosity and permeability of halite cement can be understood with reference to pore and halite size distributions. Halite cement in sandstones occurs as intergranular pore-occluding cement and is observed most commonly in ~5p.u. layers just a few meters thick. These layers have the same density and neutron log responses as a ~8-12p.u. sandstone filled with gas or light hydrocarbons. Detailed sample-bysample log interpretation in the context of the regional geology is the only way to correctly identify these features. Halite cement is usually found best developed in the cleanest and thickest parts of the reservoir. It most commonly occurs in terrigenous clastic sediments. Proximity to bedded salt is the critical factor. Case studies from the North Sea, the Berkine Basin, the West African PreSalt and East Siberia are discussed.
Assessment of Water Saturation in Carbonate Formations Honoring Complex Pore Structure: A New Insight Into Physics-Based Calibration
Authors:   The University of Texas at Austin, Alhadi Almostafa , Azizoglu Zulkuf ,   The University of Texas at Austin, Heidari Zoya ,   The University of Texas at Austin
Published: September 2022

The conventional rock physics models used for interpretation of resistivity measurements (e.g., Archie’s model) need to be calibrated using core measurements. This becomes challenging when core measurements are not available or significant vertical variation in rock types and pore structure is commonplace. Conventional models also assume homogeneous pore structure and uni-modal pore-size distribution. To overcome these challenges, we introduce a new workflow for water/hydrocarbon saturation assessment, in which model parameters are geometry related and can be estimated from analysis of the pore structure. Such workflow enables reliable interpretation of resistivity measurements in the presence of complex multi-modal pore structure. Furthermore, we investigate the consistency of the estimated model parameters (i.e., electrical constriction factor and tortuosity) in the pore-scale domain through the same rock types, for the purpose of developing a workflow for field applications. We first obtain high-resolution pore-scale computerized tomography (CT) images from rock samples in the same rock type and quantify pore-network characteristics (e.g., constriction factor, pore- and throat-size distributions) of the samples at different water saturation levels. Image analysis is used to obtain geometrical constriction factor. We obtain electrical resistivity of the samples through numerically solving Maxwell’s equations, which is used as an input in the introduced model. We successfully applied the introduced method to pore-scale images from three carbonate formations. We verified the consistency of the obtained parameters in the pore-scale domain by applying the method in other rock samples of the same rock type. Results demonstrated consistency in estimated electrical constriction factors and tortuosity values in each rock type. We observed variation of model parameters in different rock types. The introduced method successfully captured the variation of the pore structure within the formation and honored the geometrical heterogeneity of the complex carbonate rocks. Finally, we used the new workflow and Archie’s model to estimate water saturation. The new workflow enhanced water saturation estimates by 30% compared to Archie’s model with default parameters (i.e., a=1 and m=n=2). The outcomes of this paper can potentially minimize core-based calibration efforts for well-log-based water saturation assessment in rocks with complex pore structures such as carbonates. The introduced rock physics model captures the complexity of pore-network geometry and rock fabric and converged toward a more mechanistic model where most parameters have physical and geometrical meaning. The results are promising for enhanced assessment of water saturation in carbonate formations with minimal calibration efforts.
Extended Fractional Flow Theory for Steady State Relative Permeability Experiments With Capillary End Effects – Transient Solutions and Time Scales
Authors:   University of Stavanger, Andersen Pål Østebø
Published: September 2022

Steady state core flooding experiments are regularly performed for estimation of relative permeability functions which are key inputs for simulation of multiphase flow in porous media. Such tests can be time demanding, thus it is valuable to find the relation between fluid flow properties, injection conditions and the time for the desired measurements of stabilized average saturation and pressure drop to be obtained. The phases we consider are oil and water but could be any immiscible phases. An injection condition is specified by the total injected volumetric rate Qt and the fraction F of the total rate due to water. At steady state at these injection conditions there is no change with time in pressures or saturations. We consider the transition from the steady state of one injection condition, when one or both of Qt and F are changed, until the steady state of the new injection conditions have developed. The spatial saturation distributions at steady state are known analytically from solutions derived by Andersen (2021a). From the method of characteristics, a solution is constructed to describe the velocity of each saturation traveling between the two steady state profiles. The velocity for each saturation is estimated based on an effective fractional flow function that combines contributions of advective and capillary forces to one saturation dependent function. The solution allows us to interpret experimental data, forecast the time scale of the tests at each condition and suggest a more optimal scheme to conduct the experiments as they proceed. Assuming an imbibition setup, the solution implies frontal displacement and short time scales when increasing the fraction F where the flow function is convex. This is the case at sufficiently low saturations. At higher saturations the flow function becomes concave and the saturations travel with individual speeds proportional to the flow function derivative. The time scale is limited by the slowest saturation. At high saturations the saturation speed approaches zero giving an infinite time scale. In a water-wet case, capillary end effects shift the saturation profiles up to include slower high saturations and increase the time scale. In an oil-wet case the saturation profiles are shifted down such that the slowest saturations are faster or travel a shorter distance, thus reducing the time scale. The model is validated by comparing the proposed analytical solution with numerical solutions.
Spatial Sensitivity Study Essential to Geosteering Interpretation
Authors:   China National Logging Corporation, Zhu Jun , Die Yong ,   China National Logging Corporation, Tian Yuanshi ,   China National Logging Corporation, Song Yongyang ,   China National Logging Corporation, Yang Shansen ,   China National Logging Corporation, Yang Ting ,   China National Logging Corporation, Chen Yanjun ,   Maxwell Dynamics Inc., Zhou John ,   Maxwell Dynamics Inc.
Published: September 2022

To appraise the look-around and look-ahead technologies used in geosteering, an extension to the sensitivity function is presented by considering jointly with the resolution. The development is of critical importance to the data interpretation of LWD azimuthal electromagnetic tools introduced in the recent years. The extended sensitivity distribution describes the geologic boundary detectability. The spatial distribution of low-frequency electro-magnetic fields in conductive medium is dominated by two factors, namely the exponential decay as function of skin-depth and the geometric spreading which is inversely proportional to the distance cubed. The electromagnetic fields fade away rapidly and consequently so is the associated sensitivity function. The smaller field strength or poorer sensitivity far away from the tool also dictates that the resolution farther away from the tool is much worse than that near the tool. To improve the detectability of geologic target, based on the physics observed, this paper extends the spatial sensitivity function by taking the tool resolution into consideration. The space is divided into cells with the cell-size conforming approximately to the natural resolution, for example, geometric progression. The new sensitivity function is the traditional one multiplied with the cell size to better describe the look-around and look-ahead capabilities, where the emphasis is on the detection of the bed-boundaries as far ahead or around as possible. It is observed that the iso-sensitivity envelope encompassing 50% of cumulative contribution from the tools is within the distance of about one source-receiver coil-separation, L, or less. This is consistent with the depth of investigation for wireline induction logging tools defined through the integrated geometric factor at the same percentage. The observed iso-sensitivity envelope for 90% of cumulative contribution is about 2 to 3 L’s away from the tool, while the iso-sensitivity surface for 99% is observed to be from a volume of about 4L to 5L or slightly more around the tool. For various coil-configurations, it finds that the X-X (likewise Y-Y) coil-combination is more sensitive to look-ahead boundary-detection when the geologic boundary is perpendicular to the sensor. The look-around investigation with sensor parallel to the beddings may benefit relatively more from, for example, the 45-degree tilted-coil configuration.
Constructing the Public Discourse of Innovative Development (The Case of Russia)
Authors:   Southern Federal University, Kurysheva A. A. , Pokusaenko M. A. ,   Southern Federal University, Volchik V. V. ,   Southern Federal University
Published: September 2022

The discourse of innovative development has gained currency over the past decade in Russia as governmental agencies have been putting considerable effort into promoting narratives about the role of innovation in the national economy. In contrast with the post-Soviet period of the 1990s and 2000s, the 2010s in Russia have seen a shift in the public discourse as more significance started to be attached to university-business-government partnership. The study uses the empirical data collected from Integrum, an archive of mass-media sources from Russia and other ex-Soviet countries, over a 10-year period (from January 1, 2010 to July 1, 2021). Methodologically, the study relies on methods of applied narrative analysis. The study identifies five key narratives of innovative development propagated by governmental agencies and the Russian academia. Advances in science and technology were among the key priorities set by Russia’s National Security Strategy, a milestone document adopted in 2015. The government saw university-business-government partnership as the best way of ensuring innovative development. However, members of the academia as well as governmental officials themselves admitted the lack of actual cooperation and effective dialogue between business and universities. Moreover, scientists emphasized the need for more academic freedom and criticized the government for excessive control (including financial matters), which led them to underestimate the role of the state in innovative development.
Meso-Economic Modelling of the Impact of Structural Shifts in Industry on High-Tech Exports
Authors:   Ryazan State Agrotechnological University named after P. A. Kostychev, Minat V. N.
Published: September 2022

The paper aims to provide a theoretical and empirical evaluation of the impact of structural shifts in the US industry on high-tech exports. The article tests the hypothesis that there is a direct relationship between the comparative advantages of US subregions and states and the complexity of high-tech exports. The methodo­logical framework is based on meso-economic modelling, which includes the principles and technologies of index and regression analysis of US industrial development in 2011-2020. The results of the study confirm the hypotheses. More specifically, they reveal an increase in the spatial heterogeneity and asymmetry (on the level of subregions and states) that accompanies an increase in the economic and product complexity of production /distribution and regional exports. In the subregions of the country’s ‘geo-economic centre’, export meso-industry is developing faster. Interestingly, in some of the ‘semi-peripheral’ subregions, high-tech exports demonstrate a potential for growth as the groups of manufactured and exported products are becoming more complex. Thus, regional meso-economy creates competitive advantages of innovative type determined by the structural shifts in the US industry. These factors create many combinations for sustained development of territories and their export baskets, both at present and in the future.
'Law and'...a new perspective
Authors: Cati Matteo Maria
Published: September 2022

This paper reinterprets, differently from the existing literature, the relationship between law and economics not from the point of view of a lawyer-economist but rather from the point of view of an economist-mathematician, and it raises a methodological issue. To do so, some of the elements of the theory of sets are borrowed to argue that behavioral economics, its application to behavioral law and economics, and behavioral economists have generalized the pioneering work of Judge Calabresi, with reference to the famous books ‘Tragic Choices’ and ‘The Future of Law and Economics – Essays in Reform and Recollection’. Even if the usage of the theory of sets made in this paper is intuitive, some of its basics are reviewed in the appendix.
Influence of biotic and economic-anthropogenic factors on the attendance of artificial salt licks and the sex-age structure of the flock of the European moose, Alces alces (Linnaeus, 1758), in the conditions of the North-West of Russia
Authors: Sedikhin N.V. , Razygraev A.V.
Published: September 2022

The relationship between the attendance of artificial salt licks by European moose, Alces alces (Linnaeus, 1758), and biotic and economic-anthropogenic factors in the territory of the Leningrad Province was assessed. Data on the attendance of 19 mineral feeding sites obtained from automatic photo-video recorders (camera traps) were used in the analysis. Among the biotic factors that have a significant impact on attendance, the remoteness of the salt lick from the perennial water pool and the category of biotope according to the ground cover were revealed. Among the economic and anthropogenic factors – the remoteness of the salt lick from settlements with a population of more than 500 people. Similarly, the relationship between the sex-age structure of the registered moose flock with factors from the same categories was assessed. In addition, the effect of the recorded numbers of different sex-age groups on each other was assessed. A significant dependence of the registration of adult males on the area of wetlands and linear objects (power lines and gas pipelines) located within the boundaries of 1500 ha around the salt lick, as well as on remoteness from settlements, has been established. A significant dependence of the registration of yearling males on the area of wetlands around the salt lick and the number of registered adult males was established. A significant dependence of the number of registered adult females on the remoteness of the salt licks from a perennial water pool was noted. At the same time, the effect of any of the habitat groups on the recorded number of females has not been confirmed. Estimated population growth in sample areas depends on the sex ratio of registered individuals. The influence of limiting factors (predation, feed availability, hunting press) acting on moose populations in sample areas according to the methods used has not been revealed.
The range of marsh frogs (complex Pelophylax ridibundus, Amphibia, Ranidae) in Kazakhstan: Progressive dispersal or cyclic fluctuations?
Authors: Kaptyonkina A.G. , Dujsebayeva T.N. , Akhmedenov K.M. , Khromov V.A. , Krainyuk V.N. , Sarzhanov F. , Starikov S.V. , Tarasovskaya N.E. , Timoshenko A.Yu. , Titov S.V.
Published: September 2022

According to 2005 data, during the second half of the 20th century, the range of marsh frogs (Pelophylax ridibundus complex) in Kazakhstan almost doubled, which was facilitated by the unintentional introduction of these amphibians in the central and eastern regions of the country against the backdrop of favorable climate change. This paper analyzes the results of the next monitoring of the distribution of the marsh frogs in Kazakhstan in the light of the hypothesis of the ongoing dispersal of amphibians throughout the country. During the revision of literature, museum and archival materials over the past 15 years and the analysis of the authors’ field data for 2021, about 500 amphibian sighting points were collected, which is almost 2 times higher than previously known information. It has been established that the modern range of the complex occupies the territory of all major hydrographic basins of Kazakhstan: The Ural-Emba, Aral-Syrdarya, Nura-Tengiz, Balkhash-Alakol, Tobol-Ishim and Irtysh basins, of which only the last two belong to the area of oceanic runoff, the rest are the drainless inland. A chronological analysis of the data obtained for each basin made it possible to conclude that over the historical period the area of the marsh frogs’ range has changed, but mainly due to periodic reductions or expansions within the drainless inland basins, the level and mineralization of water bodies of which are determined by cyclic climate fluctuations. In a broad sense, it is proposed to talk about the constancy of the autochthonous range of the marsh frogs in the west, south and southeast of Kazakhstan. The phenomenon of “settlement” includes the movements of lake frogs within the Nura-Tengiz and Irtysh basins, where they did not live in the historical past. In geological retrospect, this process probably restores the boundaries of the Neogene distribution of representatives of the P. ridibundus complex. From the point of view of the genetic composition of the complex, one can speak of the dispersal or even expansion of the Anatolian P. cf. bedriagae, which has successfully advanced to all regions of Kazakhstan from the eastern borders of its autochthonous range in the Caspian Plain and the coasts of the Mangyshlak Peninsula.
FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUASAN KERJA KARYAWAN RUMAH SAKIT MATA PBEC
Authors: B. Isyandi  , Agus Taufiq  , Saputra Trio
Published: September 2022

This study aims to analyze the factors that affect employee job satisfaction at PBEC Eye Hospital. The data of this study consisted of primary and secondary data, which were taken through a questionnaire to 81 employees of the PBEC Eye Hospital with a sample census. The variables used are psychological factors, social factors, physical factors, and financial factors as independent variables and job satisfaction as the dependent variable. The data obtained were processed using SmartPLS. The results of this study indicate that psychological factors, social factors, and physical factors have a positive and significant effect on employee job satisfaction. And financial factors have no significant effect on employee job satisfaction
Review on the Development of Plastic Road
Authors: Wang Bo , Wang Tao , Hao Gang
Published: September 2022

Disposal of waste plastics is a serious global problem as they are not biodegradable and harmful to human health, and since these waste plastics are not scientifically treated, they cause ground and water pollution. If waste plastics are applied to road construction, it can not only solve the problem of disposal of waste plastics, but also improve the phenomenon of long construction period, frequent repairs and environmental pollution of traditional roads, and achieve the sustainable development. This article mentions two methods, one of which is to add waste plastic to bitumen, and this modified asphalt mixture and aggregate have better cohesion, stability, density and more water resistance, thus increasing the road the durability of the road increases the wear resistance and tear resistance of the road. Another method is to use waste plastics instead of bituminous mixes, with the introduction of newer industrially produced products to the market, the plastic road is making a circular infrastructure made from plastic waste a reality.
Study on Rheology and Stability of Light Curing Silicon Oxide Ceramic Slurry
Authors: Qian Jianming , Sun Baofu , Zhao Qingjuan , Sun Jinchao , Zhang Hui
Published: September 2022

In this paper, the preparation process of low viscosity light curing silicon oxide ceramic slurry and the properties of sintered samples were studied. By studying the effects of the type and concentration of dispersant and the solid content of ceramic powder on the viscosity and stability of slurry, silicon oxide ceramic slurry with low viscosity, high solid content and good stability was prepared. The properties of sintered samples of silicon oxide ceramics were verified by the compressive strength, shrinkage test and SEM observation. The results show that with stearic acid as dispersant, the mass fraction is 2wt % and the particle size of silicon powder is 10μm. When the solid content is 45wt%, the light curing ceramic slurry with the lowest viscosity and the most stable can be obtained. After curing, degreasing and sintering, the compressive strength of the SiO2 ceramic sample prepared with the optimized parameters is 70.01 MPa, and the average shrinkage is 94.67%. It has good performance. The silicon oxide grains are arranged orderly, the structure is dense.
Hüzün Turizmi Üzerine Bibliyometrik Bir Analiz
Authors: ÖZDEMİR Filiz , ÇAKMAK Tolga Fahri
Published: September 2022

Bu çalışmanın amacı, alan yazında “Hüzün Turizmi” olarak tanımlanan özel ilgiye dayalı turizm türünün, akademik çalışmalarda nasıl ve hangi kavramlar ile tanımlandığının araştırılmasıdır. Araştırmanın evrenini; 2000- 2021 yılları arasında Türkiye’de ulusal ve uluslararası dergilerde yayımlanan çalışmalar, konu ile ilgili yazılmış tezler ve kongre bildirileri oluşturmaktadır. Bu kapsamda “Google Akademik, TR Dizin ile Ulusal Tez Merkezi”nde ulaşılabilen 14 lisansüstü tez, 40 makale ve Türkiye’deki kongrelerde sunulan konuya ilişkin 6 bildiri (tebliğ) olmak üzere toplamda 60 yayın değerlendirmeye tabi tutulmuştur. Hüzün turizmine yönelik gerçekleştirilen araştırmaların literatür taraması için ikincil kaynaklardan veri toplama yöntemi kullanılmıştır. Elde edilen veriler çeşitli parametreler çerçevesinde analiz edilerek çalışmaların; yayımlandığı yıllar, anahtar kelimeler, kavramsal ve görgül olma durumları, araştırma türü, veri toplama ve veri analiz yöntemleri ile yazarların sayılarına ilişkin dağılımı incelenmiştir. Araştırma neticesinde elde edilen analize göre çalışmaların ilk olarak 2006 yılında başladığı, 2017 yılı itibariyle artış gösterdiği tespit edilmiştir. Yüzde ve frekans analizi üzerinden değerlendirilen anahtar kelimelerde ise “Savaş Alanları Turizmi” anahtar kelimelerinin ön plana çıktığı görülmektedir. Araştırmalar çok yazarlılık açısından incelendiğinde çoğunluğunun iki yazarlı çalışmalardan oluştuğu belirlenmiştir. Bu çalışmalar araştırma yöntemine göre değerlendirildiğinde tezlerde nicel yöntem tercih edilirken makale ve bildirilerde ise ağırlıklı olarak nitel yöntemin tercih edildiği gözlemlenmiştir.
Yerel Gıda Ürünlerinin Sürdürülebilirliğinde Gastronomi Müzelerinin Önemi: Kars Zavot Ekomüze Örneği
Authors: KIRBAÇ Kübra , BUCAK Turgay
Published: September 2022

Bu çalışmada gastronomi müzelerinin yerel gıda ürünleri üzerindeki sürdürülebilirlik etkisini araştırmak amacıyla yarı yapılandırılmış görüşme yönteminden yararlanılarak Kars Zavot Ekomüze üzerine bir çalışma yapılmıştır. Çalışma kapsamında Kars ilinde yaşayan yerel yöneticiler, akademisyenler ve müze kurucuları olmak üzere toplamda 14 katılımcı ile telefon aracılığıyla 30-45 dakika arasında görüşmeler gerçekleştirilmiştir. Buna göre gastronomi müzeleri, genel itibariyle yerel gıda ürünlerinin sürdürülebilir olmasında katkı sağlarken, Türkiye’de kurulan örneklerinde başta tanıtım eksikliği olmak üzere müzelerin ilgi çekici olmaması, bütçe eksikliği gibi engellerin olması sebebiyle bu alanda hedeflenen etkiye ulaşılamamaktadır. Ürünlerin üretiminin gösterilmesi, devlet desteği, sosyal medya kullanımı gibi uygulamalarla gastronomi müzelerinin bölgeye ekonomi, markalaşma, bilinirlik, sürdürülebilirlik ve sosyo-kültürel alanlarda fayda sağlayacağı düşünülmektedir. Çalışmanın sonucunda, Zavot Ekomüze’nin bölgede çekicilik rolü olduğunu, turistik hareketlilik oluşturduğunu ve bölgenin markalaşmasına fayda sağladığını göstermektedir. Elde edilen sonuçlar müzenin açılması ile birlikte unutulan ürünlerin yeniden üretilmeye başlanıldığına, var olan ürünlerin ise daha çok üretildiğine, bilinir olduğuna, satışlarının fazlalaştığına ve yerel gıda ürünlerinin sürdürülebilir olmasında fayda sağladığına işaret etmektedir.
CNN-Based Fabric Defect Detection System on Loom Fabric Inspection
Authors: TALU Muhammed Fatih , HANBAY Kazım , HATAMİ VARJOVİ Mahdi
Published: September 2022

Fabric defect detection is generally performed based on human visual inspection. This method is not effective and it has various difficulties such as eye delusion and labor cost. To deal with these problems, machine learning, and computer vision-based intelligent systems have been developed. In this paper, a novel real-time fabric defect detection system is proposed. The proposed industrial vision system has been operated in real-time on a loom. Firstly, two fabric databases are constructed by using real fabric images and defective patch capture (DPC) algorithm. Thanks to the novel developed fast Fourier transform-based DPC algorithm, defective texture areas become visible and defect-free areas are suppressed, even on complex denim fabric textures. Secondly, an appropriate convolution neural networks (CNN) model integrated negative mining is determined. However, traditional feature extraction and classification approaches are also used to compare classification performances of deep models and traditional models. Experimental results show that our proposed CNN model integrated negative mining can classify the defected images with high accuracy. Also, the proposed CNN model has been tested in real-time on a loom, and it achieves 100% detection accuracy.
Form of Conservation and spatial planning of House Betang, Suku Dayak Central Kalimantan
Authors: Bharuna S Anak Agung Gde Djaja , Dwijendra Ngakan Ketut Acwin
Published: September 2022

The development of the Betang house of the Dayak tribe in Central Kalimantan from a long house model inhabited by several families into a private house with a much changed shape and spatial pattern. Factors that cause changes that occur in general, include: changes in residents' needs; Changes in local customs and traditions, with the loss of gathering habits such as traditional feasts and tiwah rituals; and changes in the form of building elements, both in form and in the materials used. Changes in the form of houses and spatial patterns that occur are caused by changes in the functions and demands of residents as well as cultural acculturation. There needs to be conservation efforts as a tangible form of conservation in this Betang house to preserve the shape of the Betang house as before.
Psychotherapy under lockdown: The use and experience of teleconsultation by psychotherapists during the first wave of the COVID-19 pandemic
Authors: Notermans Jessica , Philippot Pierre
Published: September 2022

Background

Facing the COVID-19 pandemic, some psychotherapists had to propose remote consultations, i.e., teleconsultation. While some evidence suggests positive outcomes from teleconsultation, professionals still hold negative beliefs towards it. Additionally, no rigorous and integrative practice framework for teleconsultation has yet been developed. This article aims to explore the use and experience of teleconsultation by 1) investigating differences between psychotherapists proposing and not proposing it; 2) evaluating the impact of negative attitudes towards teleconsultation on various variables; 3) determining the perceived detrimental effect of teleconsultation, as opposed to in-person, on the therapeutic relationship and personal experience; and 4) providing insights for the development of a teleconsultation practice framework.

Method

An online survey was distributed via different professional organisations across several countries to 246 (195 women) French-speaking psychotherapists.

Results

Psychotherapists who did not propose teleconsultation believed it to be more technically challenging than psychotherapists who proposed it, but felt less constrained to propose it, and had less colleagues offering it. Attitudes towards teleconsultation showed no significant associations with therapeutic relationship, personal experience, and percentage of teleconsultation. As compared to in-person, empathy, congruence, and therapeutic alliance were perceived to significantly deteriorate online, whereas work organisation was perceived to be significantly better. While most psychotherapists proposed remote consultations, they did not provide adaptations to such setting (e.g., ascertaining a neutral video background); nor used videoconferencing platforms meeting privacy and confidentiality criteria.

Conclusion

Training and evidenced-based information should be urgently provided to practitioners to develop rigorous guidelines and an ethically and legally safe practice framework.
Multidisciplinary approach in the treatment of chronic tension headache on the background of COVID-19
Authors: Novikov Yu. О. , Akopian A. P. , Amigues F. A.
Published: September 2022

The new coronavirus infection probably affects the pathomorphosis of the disease, aggravating the course of the tension headache that the patient previously had. In the above clinical observation, the high effectiveness of the complex treatment of TH and autonomic dysfunction with central thermoregulation disorder in the framework of postcovid syndrome with the use of osteopathic correction, acupuncture and drug treatment was noted. The effectiveness of osteopathic techniques can be reinterpreted and explained through the identiﬁcation of the glymphatic system. Further studies are needed to clarify the main mechanisms of action of osteopathy in patients with the consequences of a coronavirus infection.
The content of microand macroelements in the oral ﬂuid at different intensity of dental caries
Authors: Uspenskaya O. A. , Zhdanova M. L , Kostrova E. L. , Potekhina Yu. P.
Published: September 2022

Introduction. Due to the high prevalence of caries, the monitoring of enamel and dentin state remains an actual problem in dentistry and contributes to the development of new methods for diagnosing and predicting a cariogenic situation in the oral cavity. One of these methods is the study of the remineralization and demineralization processes in the oral cavity and of the microelements′ and macroelements′ level in the oral ﬂuid.

The aim of the study is to research the level of macroand microelements in the oral ﬂuid in patients with different intensity of dental caries.

Materials and methods. 13 people aged 21 to 35 were examined, including 10 women and 3 men. Based on the results of the dental examination, 2 groups of subjects were formed: 1st (n=4) healthy individuals and patients with a compensated form of caries; 2st (n=9) patients with decompensated form of caries. The subjects collected oral ﬂuid by spitting into a test tube on an empty stomach, after brushing their teeth and rinsing their mouth three times with distilled water. Three samples were taken from each subject on different days, a total of 39 samples. The content of elements (Na, K, Ca, Mg, Fe, P, Mn) was determined by inductively coupled plasma atomic emission spectrometry.

Results. An increase in the content of most microand macroelements (Na, K, Ca, Mg and P) in the oral ﬂuid was found in patients with decompensated caries compared with the compensated form and healthy people (p<0,05). Perhaps, in the absence of a carious process or compensated caries, the mineral components are concentrated in hard tissues and the remineralization-restoration processes of the tooth mineral structures prevail.

Conclusion. The study of the content of Na, K, Ca, Mg and P in the oral ﬂuid can be used to diagnose and predict the course of the carious process.
Korean Nursing Women who emigrated to Germany and the 68th Movement
Authors:   Korea Association of World History and Culture, Na Hye-Sim
Published: September 2022

The process of immigration and settlement of Korean nursing women in Germany in the 1960s and 1970s was a process in response to the various social changes that were going on in German society. Their period of living in Germany mostly overlaps with the period of the 68th Movement and the social changes that resulted from it. The social changes caused by the 68th movement have an impact on some of Korean women's recognition of their identity as migrant women workers from the Third World. It was not simply a passive learning process, but an active self-discipline process. Based on the self-identity learned in this process, women play a central role in leading the struggle for the right to stay in 1977-78 to success. They revealed their identity as women from the Third World who live as transnational beings in German society. The awakening of its identity led to an organized new social movement and led to solidarity with various underprivileged people living outside the boundaries.
Factores que inciden en el envejecimiento digno de los adultos mayores de la parroquia Santa Rosa– Ambato
Authors: Chango Andagana Martha María , Barahona Néjer Amílcar Alexander , Cárdenas Lata Bertha Janneth , Herrera Hugo Blanca de los Ángeles
Published: September 2022

El objetivo de la investigación  fue analizar las características de los factores que inciden en el envejecimiento de los adultos mayores en Ambato,  para lograr este objetivo se utilizó el método descriptivo-analítico, los hallazgos encontrados se refieren a que los factores son  diversos en función de las necesidades y carencias que tienen las personas que han llegado a esta etapa de sus vidas, ya que la realidad de un jubilado que cuenta con su pensión económica mensual no es igual a quienes no la poseen, y más aún a quienes viven el desarraigo de su familia, sin dejar de mencionar que a una precaria situación de vida de los mayores, generalmente se suman problemas serios de salud e incapacidades las cuales demandas significativos recursos que no están en posibilidades de solventar, por esta razón la corresponsabilidad que debe existir entre los organismos del Estado, sean estos nacional o locales, debe estar asociado a las atenciones del núcleo familiar más cercano al adulto mayor, un hallazgo importante de esta investigación explica los factores que inciden en un envejecimiento digno que encierran atención médica y psicológica, accesos seguros para una movilidad sin peligros, ingresos económicos necesarios para cubrir sus necesidades básicas y apoyo familiar para quienes tienen esta posibilidad.