bluuebunny/crossref_metadata_2025 huggingface dataset:
Adrenal insufficiency in immunochemotherapy for small-cell lung cancer with ectopic ACTH syndrome
Authors: Nakajima Hiroki , Niida Yasuhiro , Hamada Eriko , Hirohito Kuwata , Ota Masahide , Okada Sadanori , Mohri Takako , Kurematsu Yukako , Hontsu Shigeto , Muro Shigeo , Takahashi Yutaka
Published: September 2021

Ectopic ACTH (adrenocorticotrophic hormone) syndrome (EAS) is rarely associated with small-cell lung cancer (SCLC). Although chemotherapy is initially effective for SCLC, complicated EAS scarcely improves. Recently, immune checkpoint inhibitors have been used to treat SCLC. Atezolizumab plus chemotherapy for SCLC improved progression-free survival compared to conventional chemotherapy. However, little has been reported on the efficacy of the combination therapy for SCLC with EAS. We report a 72-year-old male who presented with 4-week history of leg oedema, proximal myopathy, weight loss, and worsened symptoms of diabetes and hypertension. Laboratory findings revealed hypokalaemia, increased plasma ACTH, and serum cortisol levels. Cortisol levels were not suppressed by the high-dose dexamethasone test. Chest and abdominal CT revealed a right lower lobe tumour with multiple metastases on the hilar lymph nodes, liver, lumbar spine, and bilateral enlarged adrenal glands. The patient was diagnosed with stage 4B SCLC with EAS. Hypercortisolaemia was then treated with metyrapone and atezolizumab plus chemotherapy, which was started for SCLC. After 10 days, the tumour shrank noticeably, and the ACTH level drastically decreased concomitantly with low cortisol levels with symptoms of fever, appetite loss, and general fatigue. Hydrocortisone treatment was initiated, and the symptoms resolved immediately. We describe a case of SCLC with EAS treated with atezolizumab plus chemotherapy, presenting with adrenal insufficiency. Close observation is required for patients with adrenal insufficiency receiving atezolizumab plus chemotherapy because of its stronger effect. Furthermore, advances in cancer therapy and care for endocrine paraneoplastic syndrome needs to be adapted.

Learning points

The immune checkpoint inhibitor atezolizumab has recently been approved for the treatment of small-cell lung cancer (SCLC).

Approximately 1–6% of tumour ectopically produce ACTH and cause ectopic ACTH syndrome (EAS) as an endocrine paraneoplastic syndrome.

The use of combined chemotherapy and atezolizumab in the ectopic ACTH syndrome secondary to small-cell lung cancer may cause a precipitous fall in circulating ACTH/cortisol, resulting in symptomatic adrenal insufficiency

The advances in cancer therapy and treatment for endocrine paraneoplastic syndrome need to be adapted.
Synthesis and characterization of graphene oxide flakes for transparent thin films
Authors: Abaszade R.G. , Mamedova S.A. , Agayev F.G. , Budzulyak S.I. , Kapush O.A. , Mamedova M.A. , Nabiyev A.M. , Kotsyubynsky V.O.
Published: September 2021

We have synthesized large scale, thin, transparent graphene oxide (GO) flakes by Hummer’s method and investigated their suitability for fabrication of transparent nanocomposites. The GO flakes were comprehensively characterized by X-ray diffraction, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX), Raman spectroscopy and Differential Scanning Calorimetry (DSC). X-ray diffraction displayed the peak of graphene oxide at 9°degree, which is characteristic peak of GO in agreement with the literature results. Scanning Electron Microscopy images revealed that thin, transparent, flake form GO with 14,8 µm lateral size and 0,31µm thickness were synthesized. The comparison with literature results show that for the first time, our group could synthesize large scale, thin and more transparent GO flakes by simple Hummer’s method using simple dispersed graphite. EDX measurements indicate the formation of layered structure with oxygen containing functional groups. The intensity ratio between D and G peaks in the Raman spectra proves that less defective GO flakes have been synthesized. The solution ability of the synthesized material indicate that high quality GO flakes were synthesized, which make them effective soluble material due to oxygen containing groups formed on the graphene plane during synthesis process.DSC results shows that these flakes are thermally stable till 200°C.  Due to high solubility properties, large scale and transparency they can be very useful in fabrication of high optical transparent nanocompoties for replacement indium tin oxide transparent conductors in solar panels, biomedical applications and microwave absorbers for electromagnetic interference (EMI) environmental protection.
Preparation and performance of modified montmorillonite-reinforced wood-based foamed composites
Authors: Li Qingde , Liang Yingyi , Chen Feng , Sang Tonghui
Published: September 2021

Wood fiber was modified by impulse-cyclone drying treatment with poplar and montmorillonite as reinforcing materials; mMMT/polypropylene/wood fiber foaming composite was prepared by the hot compression process. The effects of modification, temperature, and content of montmorillonite on physical and mechanical properties of the composite were analyzed. Mechanical properties, porosity, shrinkage, water absorption, and thickness swelling tests showed that when mMMT reinforcement was 5 wt%, the best performance was achieved. The scanning electron microscopy observations showed that bubble holes were distributed widely and evenly, and mMMT appeared in the cell gap and was encapsulated by polypropylene, which maximized the bonding effect. Flexural strength was 27.5 MPa, flexural modulus was 2110 MPa, tensile strength was 20.0 MPa, and impact strength was 6.30 KJ/m2. When absolute volume of dense solid reached 70.8 cm3, porosity was 21.4% and shrinkage was 1.17%, which indicated that the water absorption increased most remarkably under that test condition. When equilibrium water absorption reached 9.28%, the thickness swelling decreased by 25%. The results showed that mMMT effectively optimized mechanical properties of wood-based foamed composites and improved hygroscopic properties.
Direct conversion of fructose to 5-ethoxymethyl-furfural catalyzed by ultra stable Y zeolite
Authors: Xu Guizhuan , Zhang Shaohao , Zheng Zhangbin , Wang Chen , Wang Shijie , Tao Hongge
Published: September 2021

5-Ethoxymethylfurfural (EMF) is a new type of biofuel with a high energy density and excellent fuel properties. One-pot production of EMF from renewable carbohydrate catalyzed by heterogeneous catalysts has the potential to be an attractive reaction pathway. In this study, fructose was directly converted to EMF in ethanol medium catalyzed by ultra stable Y zeolite (USY). The effects of different reaction conditions on EMF yields were investigated, and an optimum reaction condition was obtained by utilizing response surface methodology. Under the optimum reaction conditions, which were a temperature of 132 °C, substrate density of 60 g/L, and catalyst dosage of 2.1 wt%, a maximum EMF yield of 73.8 mol% with the prediction error of 1.6% was achieved in 25 min. Moreover, the reusability of USY and characterization were evaluated. This study demonstrated a promising strategy for EMF production from fructose.
A randomized comparative study of platelet-rich fibrin along with hydroxyapatite graft for the treatment of 3-walled defects in chronic periodontitis
Authors: Thetay Anshuj Ajayrao , Kumar Santosh , Irfan Mohammed , Lund Rafael Guerra , Desai Khushboo , Hirani Tanvi , Sevak Jeel
Published: September 2021

Background. Platelet Rich Fibrin (PRF) is a concentrate of leucocyte and platelets that contains various polypeptide growth factors. It has immense potential for use as a periodontal regenerative material in periodontal defects. Porous hydroxyapatite (HA) has long been used as bone grafting material. Recently it has been reported that when PRF is used in combination with HA, itgives a synergistic effect and results in a better periodontal regeneration. The present study aims to explore the clinical and radiographic effectiveness of autologous PRF versus PRF+HA in the regenerative treatment of intrabony defects (IBD) in patients with chronic periodontitis.

Methods. Sixty patients with IBDs were divided into test and control groups. The test group patients were treated with autologous PRF, whereas the control group patients were treated with PRF+HA. Clinical parameters were recorded at baseline, three months, six months and nine months’ time interval. Radiographic measurements were recorded at baseline and nine months.

Results. A reduction in PI, MGI, PPD, RAL, and IBD was observed in both the groups at nine months. Mean IBD reduction in the control group was 3.70 ± 1.16 mm, whereas, the mean reduction in the test group was 4.80 ± 1.03 mm, showing a significant reduction in IBDs. Similarly, the percentage of bone fill in the test group was 65% ± 3.67%, whereas bone fill in controls was 56.7% ± 3.56%, showing a significant bone fill in the study group.

Conclusion. Treatment of IBDs with PRF+HA showed a significant improvement in all the clinical and radiographic parameters. When HA was added to PRF, it increased the regenerative effect in the treatment of 3 wall IBDs.
A survey on dental students’ perception regarding online learning during COVID-19 pandemic
Authors: Kui Andreea , Jiglau Anca Labunet , Chisnoiu Andrea , Negucioiu Marius , Balhuc Silvia , Constantiniuc Mariana , Buduru Smaranda
Published: September 2021

Background and aims. This study aimed to assess the students’ opinion about the efficiency of online teaching and also about the methods and features to be implemented even after this pandemic period would pass.

Methods. A questionnaire was formulated in order to evaluate the students’ perception about the teaching methods used by the Faculty of Dentistry, which was distributed through email.

Results. The answers of 208 students were analyzed. There were 157 women and 51 men, 119 were from Cluj County, while 89 were from other Romanian counties; 102 of the students were in the 4th year of study, while 62 were still in the preclinical years (1st, 2nd, 3rd), and the rest of 44 of the subjects, were in the 5th or 6th year of study. 85.8% of the respondents were satisfied with the traditional lectures, 51.7% considered that online lectures were more useful than the traditional. 187 (88.6%) of the students were satisfied with the traditional practical activities, while 37 (16.1%) believed that online activities were more useful to them, 111 (52.6%), believed that they were able to communicate better with the teacher during the online lectures.

Conclusions. Overall positive responses were reported regarding the acceptability and usability of online learning. The students viewed online learning helpful as a supplement to their learning rather than a replacement for traditional teaching methods.
Regional measurement of the hotel sector development of a tourist destination (on the example of Odessa region, Ukraine)
Authors: Nezdoyminov Sergii G. , Baldzhy Maryna D. , Kniazhkovska Hanna O.
Published: September 2021

In the conditions of transformation of the national economy and intensification of competition in the regional tourist markets, Ukrainian hotel business enterprises have an important problem related to increasing the efficiency of filling hotel places and attracting tourist flows. One of the ways to solve this problem is to form a management measures based on forecasting the length of stay of tourists in accommodation facilities, load levels of hotel enterprises in tourist destinations of Ukraine, planning the production of competitive hotel services that can meet the needs of foreign and domestic consumers, market demand. This problem is especially important in the context of overcoming the effects of the global COVID-19 pandemic. The purpose of the article is to identify trends in the hotel business in the tourist regions of Ukraine and outline the prospects that can be realized in post-crisis conditions. The study used a statistical method of trend analysis of the dynamics of the duration of tourists in hotels, which aims at the establishing patterns of changes in the levels of the studied indicators over time, to identify the main trend of this phenomenon. The example of Odessa region proved that the evaluation of the hotel business areas are the basis for predicting spatial and temporal relationships in the regional economy for the development of hotel business in other tourist destinations, increase their competitiveness and improve the marketing of tourist flows. According to the calculations, the annual decrease in the length of stay of tourists for the period 2021-2022 in hotel establishments of the Odessa region is forecasted. The experience of experimental verification of the proposed approach to forecasting the length of stay of tourists in hotel establishments shows that the proposed research methods can form modern tools for diagnosing the current state of regional markets for hotel services and making management decisions.
Continuous operator method application for direct and inverse scattering problems
Authors: Boykov Ilya V. , Roudnev Vladimir A. , Boykova Alla I. , Stepanov Nikita S.
Published: September 2021

Abstract. We describe the continuous operator method for solution nonlinear operator equations and discuss its application for investigating direct and inverse scattering problems. The continuous operator method is based on the Lyapunov theory stability of solutions of ordinary differential equations systems. It is applicable to operator equations in Banach spaces, including in cases when the Frechet (Gateaux) derivative of a nonlinear operator is irreversible in a neighborhood of the initial value. In this paper, it is applied to the solution of the Dirichlet and Neumann problems for the Helmholtz equation and to determine the wave number in the inverse problem. The internal and external problems of Dirichlet and Neumann are considered. The Helmholtz equation is considered in domains with smooth and piecewise smooth boundaries. In the case when the Helmholtz equation is considered in domains with smooth boundaries, the existence and uniqueness of the solution follows from the classical potential theory. When solving the Helmholtz equation in domains with piecewise smooth boundaries, the Wiener regularization is carried out. The Dirichlet and Neumann problems for the Helmholtz equation are transformed by methods of potential theory into singular integral equations of the second kind and hypersingular integral equations of the first kind. For an approximate solution of singular and hypersingular integral equations, computational schemes of collocation and mechanical quadrature methods are constructed and substantiated. The features of the continuous method are illustrated with solving boundary problems for the Helmholtz equation. Approximate methods for reconstructing the wave number in the Helmholtz equation are considered.
Weighted Measures of Pseudorandom Binary Lattices
Authors: Liu Huaning , Yang Yinyin
Published: September 2021

In cryptography one needs pseudorandom sequences whose short subsequences are also pseudorandom. To handle this problem, Dartyge, Gyarmati and Sárközy introduced weighted measures of pseudorandomness of binary sequences. In this paper we continue the research in this direction. We introduce weighted pseudorandom measure for multidimensional binary lattices and estimate weighted pseudorandom measure for truly random binary lattices. We also give lower bounds for weighted measures of even order and present an example by using the quadratic character of finite fields.
Localization Operators and Uncertainty Principles for the Hankel Wavelet Transform
Authors: Ghobber Saifallah , Hkimi Siwar , Omri Slim
Published: September 2021

The aim of this paper is to prove some uncertainty inequalities for the continuous Hankel wavelet transform, and study the localization operator associated to this transformation.
Some Functional Upper Bounds for Fejér’s Sine Polynomial
Authors: Chong Jing Quan , Huang Xing Chen , Lee Tuo Yeong , Li Jing Tao , Sim Hui Xiang , Soh Jing Ren , Tan Gabriel Jiaxu , Tai Jay Kin Heng
Published: September 2021

We prove that

for all integers n ≥ 1 and ɵ ≤ 8 ≤ π. This result refines inequalities due to Jackson (1911) and Turán (1938).
A ghost in the mist: extension of the known range of Colombian Weasel, Neogale felipei (Izor & de la Torre, 1978) (Carnivora, Mustelidae), in the Cordillera Occidental
Authors: Cepeda-Duque Juan C. , Link Andrés , Mazariegos Luis , Ledesma-Castañeda Elver , Rendón-Jaramillo Uriel , Ramírez-Chaves Héctor E.
Published: September 2021

The Colombian weasel, Neogale felipei (Izor & de la Torre, 1978), is one of the most enigmatic and threatened carnivores in South America, with only six confirmed records in the Andes of Ecuador and Colombia. During a long-term trail camera survey conducted at Mesenia-Paramillo Natural Reserve, we recorded the northernmost occurrence of the species, which extends its distribution by approximately 120 km to the north from the nearest previously known locality in Colombia. We also provide some comments on its natural history.
Odpowiedzialność Skarbu Państwa wobec akcjonariuszy (udziałowców) upadłego za szkodę wyrządzoną przez sąd upadłościowy poprzez niesłuszne orzeczenie o upadłości
Authors:   Uniwersytet Opolski, Polska, Adamus Rafał
Published: September 2021

This study addresses the issues related to the State Treasury’s liability for damages towards the debtor’s shareholders due to an erroneous decision on the bankruptcy option instead of the restructuring option. The proceedings are initiated at the request of the entitled person. The court decides about opening the proceedings. In practice, there may be a situation in which competing applications are submitted, either aimed at liquidating the debtor’s assets or at its restructuring. The study refers to two legal states: the legal state in force in 2003–2015 and the legal state in force since 2016. The study analyzes the statutory criteria for resolving the conflict between the liquidation and restructuring option, and the premises of the State Treasury’s liability for damages. In the event of such a conflict, the insolvency law gives priority to restructuring over liquidation.
Skarga kasacyjna a sprawy zakwalifikowane do postępowania uproszczonego
Authors:   Uniwersytet Gdański, Polska, Mróz-Szarmach Dominika
Published: September 2021

The article examines the admissibility of cassation in the field of labour law cases and social security cases, which are classified in simplified proceedings and, as the case may be, heard in those proceedings or heard without the application of the provisions on those proceedings. The paper refers to the current wording of the Polish Civil Proceedings Code and also discusses the legal situation prior to the amendments of the Polish Civil Proceedings Code of 2017 and of 2019, as well as provides de lege ferenda comments.
Komunikacja niewerbalna w mediacjach
Authors:   Uniwersytet Rzeszowski, Polska, Plis Jan
Published: September 2021

In Poland there is no system or comprehensive approach to the issue of using non-verbal communication in mediation. Usually, the matter ends with a description of some forms of body language. A lack of knowledge and skills in the scope of non-verbal communication has a negative impact on the mediation practice. The aim of this paper is to present a structured compilation of non-verbal forms and signals which can be applied in mediation. Furthermore, mediators’ skills in this scope were underlined. The analytical-functional method was used herein. An attempt was made to look at the matters related to using non-verbal communication in mediation from the theoretical and practical perspective. Due to the limited frameworks of the paper, the most significant and dominant non-verbal signals in mediation were selected for presentation. Firstly, the essence of non-verbal communication was addressed. Then, the principles of reading body language were presented. Next, signals occurring in non-verbal communication were discussed. Their role in communication and issues related to reading them properly were underlined. The paper ends with conclusions drawn from the conducted analysis.
Detenčné konanie v Slovenskej Republike
Authors:   Univerzita Pavla Jozefa Šafárika v Košiciach, Slovenská republika, Sudzina Milan
Published: September 2021

In the article entitled “The Detention Proceedings in the Slovak republic”, the author analyzes the issue of proceedings for the admissibility of taking and holding in a medical facility. The article pays attention to the reasons, principles and course of the detention proceedings. The aim of this article is through the analytical method to deal in detail with the rights and obligations of a person taken over and held in a medical facility and in particular the protection of his personal freedom.
Instytucjonalizacja społeczeństwa obywatelskiego z perspektywy prawa Unii Europejskiej
Authors:   Uniwersytet Jana Kochanowskiego w Kielcach, Polska, Świerczyński Piotr
Published: September 2021

The institutionalization of civil society in European Union law is a mechanism created as a result of various political, historical and cultural events. Civic society is the result of a specific historical process, but nevertheless it is constantly subjected to various changes, therefore it can be said that it is constantly being created “before our eyes”. Europe of citizens, understood as a postulate to identify the citizens of the European Union with European structures, is manifested, inter alia, in the institutions of European civil society shaped by these structures. These institutions include, for example, citizenship of the European Union and the rights constituting its constituent element, such as the right to petition the European Parliament, the right to lodge a complaint to the European Ombudsman, and the European Citizens’ Initiative. Therefore, these institutions of EU law are undoubtedly a legislative attempt to implement the idea of a European civil society. The citizens of the European Union are more and more willing to use from the institutions concerned, which to some extent proves their effectiveness. However, a hindrance the ubiquitous EU bureaucracy and far-reaching formalism, which results in, inter alia, declare many complaints, petitions and initiatives inadmissible. The assessment of the institutionalization of the European civil society, based on the analysis of the intensity of use and usefulness of the above-mentioned institutions by the citizens of the European Union, is therefore rather positive, although the European Union still has a long way to go to a state that could be considered satisfactory.
O możliwości kumulacji roszczeń w postępowaniu uproszczonym
Authors:   Katolicki Uniwersytet Lubelski Jana Pawła II w Lublinie, Polska, Wójcik Dominika
Published: September 2021

The article presents the issue of the cumulation of claims in simplified proceedings. In order to present the subject, reference was made to the purposes of the separate proceedings, as well as the institution of the cumulation of claims in ordinary proceedings. The article also refers to the issue of joint participation and indicates the consequences of unacceptable cumulation of claims in simplified proceedings. An attempt was also made to evaluate the changes introduced to the Act of 17 November 1964 – Code of Civil Procedure in the scope of the subject discussed in the article, which have been in force in the legal order since November 2019.
Prawna ochrona nazw jako wartości niematerialnych na gruncie ustawy o ochronie zabytków i opiece nad zabytkami
Authors:   Uniwersytet Rzeszowski, Polska, Lizak Agata
Published: September 2021

Regulations of the Act from 23 July 2003 on the Protection of Monuments and the Guardianship of Monuments concerns especially material heritage. Nevertheless, the legislator in several articles of mentioned act has referred also to intangible values, such as geographical, traditional and historic names. As regards the question of their protection, it has been mentioned only in two laconic provisions – one of them concerns possibility of names’ protection in general (art. 6 par. 2), while the second one stipulates that the name of immovable historic monument entered in the register of monuments may be also listed in such register. Bearing this in mind, the reflection is needed under which circumstances name may be protected and what are the specific rules of such a protection. Given the above, in the article, as a first issue, status of the names has been analyzed. Furthermore, attention has been paid to the scope of protection.
Dochodzenie cywilnoprawnych roszczeń pacjentów w postępowaniach przyspieszonych – uwagi na tle pandemii COVID-19
Authors:   Uniwersytet Kardynała Stefana Wyszyńskiego, Warszawa, Polska, Manikowski Filip
Published: September 2021

The currently prevailing COVID-19 pandemic and the associated heavy burden on the Polish health care system are conductive to medical errors committed by medical personnel, violating patients’ rights, as well as their personal rights. The pandemic also negatively affects the justice system. It is related to the staff shortages both among judges and the administrative staff of courts. Bearing in mind, on the one hand, the possible increase in claims brought by the patients and, on the other hand, the reduction of the efficiency of Polish courts, it seems advisable to establish whether these claims can be heard in accelerated proceedings, the execution of which seems to be a lesser burden for courts. This analysis is justified because the amendment to the Code of the Civil Procedure in 2019 significantly changed the provisions regulating the above-mentioned proceedings. This study outlines the claims that patients are entitled to in relation to the COVID-19 pandemic and which of them can be considered in a particular accelerated procedure.
Una caracterización sociolingüística de la comunidad de habla de Miraflores (Boyacá-Colombia)
Authors: D’Olivare Nelson , Casteblanco Liliana
Published: September 2021

Este artículo se desprende de la investigación sociolingüística titulada “Caracterización del español hablado en Miraflores (Boyacá)”, cuyo objetivo fue caracterizar la comunidad de habla de Miraflores (Boyacá). Siguiendo la metodología sociolingüística se recolectó un corpus del habla espontánea de dieciocho usuarios del español en Miraflores (Boyacá). La comunidad de habla de Miraflores (Boyacá) se caracteriza no solo porque comparten territorio, sino también porque comparten el habla y sus variables manifestadas en sus turnos de habla. La relevancia de este trabajo radica en distinguir al municipio de Miraflores (Boyacá) como una comunidad de habla; en este sentido, se abordaron aspectos sociales, económicos, históricos, culturales y lingüísticos, desde el campo de la sociolingüística.
Perbandingan Pemberian Ketorolak dengan Parecoxib Intravena terhadap Kadar Trombosit, Aggregasi Trombosit, dan Profil Koagulasi pada Operasi Seksio Sesarea
Authors: Salim Hendra , Ahmad Muhammad Ramli , Arif Syafri Kamsul , Salam Syamsul Hilal , Arrasjid Zulkarnain , Tan harles Wijaya
Published: September 2021

Pengelolaan nyeri pascabedah bertujuan menghasilkan analgesia yang optimal serta menghambat respons stres akibat pembedahan. Pengaruh OAINS baik COX 1 dan COX 2 terhadap trombosit baik jumlah maupun aggregasinya perlu dinilai untuk menentukan obat terpilih yang aman dalam mengatasi nyeri pascabedah. Penelitian ini bertujuan membandingkan pemberian ketorolak dengan parecoxib intravena terhadap jumlah trombosit, aggregasi trombosit, dan profil koagulasi pada operasi seksio sesarea. Penelitian ini menggunakan uji klinis acak tersamar ganda. Penelitian dilakukan di RSUP Wahidin Sudirohusodo Makassar pada bulan Oktober 2020–Maret 2021. Pengukuran dilakukan di awal dan setelah perlakuan dengan jumlah sampel masing-masing 11 orang. Data dianalisis menggunakan uji statistik Independen T-Test. Tidak berbeda bermakna perubahan kadar trombosit pada pemberian ketorolak dengan parecoxib sebagai analgesia pascabedah seksio pasca 24 jam dan pasca 48 jam (p>0,05). Berbeda bermakna perubahan agregasi trombosit pada pemberian ketorolak dengan parecoxib sebagai analgesia pascabedah seksio pasca 48 jam (p<0,05). Parecoxib tidak menyebabkan penurunan agregasi trombosit sehingga dapat digunakan sebagai alternatif untuk analgetik pascabedah terutama untuk pasien yg mengalami gangguan hemostatis. Parecoxib tidak menyebabkan gangguan faal hemostasis dibanding dengan ketorolak. Parecoxib dan ketorolak tidak memengaruhi jumlah trombosit.
Experiencia del cliente, confianza y lealtad de los millennials en el sector bancario de la ciudad de Cuenca-Ecuador
Authors: Vallejo Bojorque Adriana Priscila , Cavazos-Arroyo Judith , Lagunez-Pérez Mario Alberto , Vásquez-Herrera Sofía Elba
Published: September 2021

El objetivo de esta investigación fue explicar el efecto de la experiencia del cliente bancario sobre la confianza y el efecto de esta última sobre la lealtad del cliente, logrando así complementar investigaciones anteriores donde se sugiere explorar con claridad la red nomológica de los constructos que actúan como mediadores en la relación entre la experiencia del cliente y la fidelidad del mismo. La muestra estuvo conformada por 1231 usuarios de la banca de la ciudad de Cuenca-Ecuador que forman parte de la generación conocida como millennials, segmento de interés por sus características y comportamiento de compra. Para el análisis de los datos se utilizó el modelo de ecuaciones estructurales y el software PLS (Partial Least Square). Los resultados evidencian que existe un efecto significativo de la experiencia del cliente sobre la confianza en la banca y a su vez un efecto similar entre la confianza y lealtad del cliente; además, se confirma que la confianza representa una variable que antecede a la lealtad. Los rasgos y comportamientos de los millennials, conocedores de la tecnología e Internet, evidencian una relación entre las variables que son parte del modelo propuesto y aplicado en el sector bancario.
Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
Authors: Wang Di , Li Yan , Zhai Qian-qian , Zhu Yun-feng , Liu Bei-yan , Xu Yun
Published: September 2021

Testicular damage and testosterone secretion disorder are associated with diabetes mellitus. Quercetin,  a common flavonoid, has antioxidant, anti-cancer,  and blood sugar lowering effects. Therefore, this study aims to investigate the effect of quercetin on the reproductive system of male rats with diabetes in vivo and in vitro and elucidate its mechanism. Streptozotocin (STZ)  induction was used to establish a diabetes model in forty male Sprague Dawley (SD) rats, which were subsequently administered with 20 or 50 mg/kg of quercetin. Leydig cells of rat testes were treated by high glucose (HG) followed by 5 or 10 μM quercetin. Two doses of quercetin increased rat body weight and testicular weight, decreased blood glucose,and inhibited oxidative stress. RT-qPCR and Western blotting revealed that quercetin alleviated STZ-induced testicular damage and promoted testosterone synthesis. Both doses of quercetin reduced ROS and MDA levels, and increased SOD level in HG-treated cells. Both, in vivo and in vitro results confirmed that a high dose of quercetin was more effective. MiR-1306-5p was upregulated in testicular tissue of diabetic rats and HG-treated cells. 17β-hydroxysteroid dehydrogenase (HSD17B7) was a target of miR-1306-5p and HSD17B7 was downregulated in STZ-induced rat tissues and HG-treated cells. HSD17B7 overexpression reversed the increase of C/EBP homologous protein (CHOP) and glucose-regulated protein 78 (Grp78) protein levels as well as eIF2α phosphorylation level and promotion of cell apoptosis caused by miR-1306-5p overexpression. Moreover, overexpression of HSD17B7 activated the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) axis in HG-treated cells. In conclusion, quercetin inhibits ER stress and improves testosterone secretion disorder through the miR-1306-5p/HSD17B7 axis in diabetic rats.
СТАНОВЛЕНИЕ КОМПЕТЕНЦИИ СУБЪЕКТОВ РОССИЙСКОЙ ФЕДЕРАЦИИ В СФЕРЕ ИНФОРМАЦИОННОГО, АДМИНИСТРАТИВНОГО И ИНЫХ ОТРАСЛЕЙ ПРАВА ДО ПРИНЯТИЯ КОНСТИТУЦИИ РОССИЙСКОЙ ФЕДЕРАЦИИ 1993 Г.
Authors: MERKULENKO Alexander Alexandrovich
Published: September 2021

Период с момента образования советского государства до принятия Конституции Российской Федерации 1993 г. является условно переходным: федерация уже была провозглашена, но у субъектов этой федерации реальные собственные полномочия появились и окончательно оформились только через семьдесят лет. Хотя объём этих полномочий изменялся в ходе существования Российской Федерации, основа формирования компетенции субъектов была заложена именно в предшествующие этапы развития федерализма. Конечный результат, который мы сейчас имеем, определён теми правовыми аксиомами, которые были созданы в советское время и в ходе подготовки Конституции Российской Федерации 1993 г. После распада СССР у Российской Федерации имелись выраженные черты асимметрии, связанные с подъемом национализма, а порой и сепаратизма в отдельных республиках. Асимметрия выражалась в закреплении более широкого объема полномочий республик в основных конституционноправовых актах того времени — Федеративном договоре и Конституции 1978 г. В последующем, однако, произошёл сдвиг в сторону симметрии и централизации, республики были фактически приравнены к остальным субъектам и многие конституционно- правовые гарантии компетенции субъектов РФ были исключены.
СООТНОШЕНИЕ СВОБОДЫ ИНФОРМАЦИИ И ПОТРЕБНОСТИ ОХРАНЫ ЗДОРОВЬЯ НАСЕЛЕНИЯ В МЕЖДУНАРОДНОМ ПРАВЕ
Authors: Richter Andrei Georgievich
Published: September 2021

В статье исследуются вопросы определения понятия «защиты общественного здоровья» как возможного ограничителя свободы информации, соотношения права на здоровье, права на получение информации, права на свободу слова и общественной потребности в защите здоровья населения. Автор обращается к практике Европейского суда по правам человека и других правозащитных межгосударственных органов.
ПАНДЕМИЯ И ИНФОРМАЦИОННЫЕ ПРАВА ГРАЖДАН: ОПЫТ УЗБЕКИСТАНА
Authors: Saidov Akmal Kholmatovich
Published: September 2021

статье рассматриваются вопросы обеспечения прав и свобод человека и гражданина в период пандемии, делая акцент на том, что органы государственного управления должны в полном объеме уважать право на свободное выражение мнений и право на доступ к информации, ограничивая их только в пределах, допускаемых международными стандартами. Дается краткий обзор принимаемых мер, направленных на защиту информационных прав граждан в Республике Узбекистан.
ПРОБЛЕМЫ СУДЕБНОЙ ЗАЩИТЫ АВТОРСКИХ И СМЕЖНЫХ ПРАВ И ПОДСУДНОСТИ СУДЕБНЫХ ДЕЛ О НАРУШЕНИИ ПРАВ В ИНТЕРНЕТЕ
Authors: Buzova Natalia Vladimirovna
Published: September 2021

Как правило, объекты авторского права и смежных прав обладают внешними характеристиками формы, которые позволяют однозначно их идентифицировать и отличать один вид результата интеллектуальной деятельности от другого. В отдельных случаях отличия формы внешнего выражения объекта состоят в деталях. Примерами таких близких по форме выражения объектов могут служить аудиовизуальные произведения, видеозаписи, записи сообщений телепередач. Несмотря на внешнее сходство объектов, защита прав на такие объекты, в том числе в судебном порядке, будет отличаться. В статье проводится сравнительный анализ указанных объектов. Автор обращает внимание на проблемы защиты прав на рассматриваемые объекты в условиях ограниченной сферы действия международных договоров в области смежных прав.
LEARNING AMID COVID-19: MEDICAL STUDENTS INVOLVEMENT IN PATIENT EDUCATION & DISEASE AWARENESS
Authors:   Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico, Segura-Azuara NA , Lopez M ,   Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico
Published: September 2021

The COVID-19 pandemic has nurtured meaningful transformations in educational contexts; even highly traditional contexts were open about transforming approaches and methodologies. Medical professionals' education relies heavily on presence-based interaction with patients, for example, to develop community activities such as patient education, which needed to continue despite the school lockdown. As part of an intervention, medical students designed a patient education and disease awareness campaign through social media. The objective of this study was to assess the transformation of patient education and disease awareness strategies to the new remote format. The methodology considered a quantitative approach with a descriptive, and crosssectional design. The sample consisted of 34 medical students enrolled in an endocrine diseases course. Each team designed the material for the campaign based on the literature research they performed. Three tutors evaluated each team using a 5-point Likert scale addressing: disease, posts, survey, and overall assessment. Analysis of results included mean, standard deviation, and linear regression. With a correlation coefficient of 0.745 and a standard error of 0.21, the study found a high correlation between variables for each team. The results show that the transformation of this educational experience was key to offer an engaging educational learning experience for medical students. The campaigns held on social media platforms received a favorable response, as the engagement through comments and likes from their followers show, which helped on tunning the contents to relate closely to the specific audience. Keywords: higher education, educational innovation, professional education, COVID-19 pandemic adaptations, patient education
REMOTE-SYNCHRONOUS SIMULATION OF AN EMERGENCY ROOM FOR MEDICAL STUDENTS
Authors:   Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico, Hambleton A , Lopez M ,   Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico
Published: September 2021

The pandemic’s historical challenge has forced the international academic community to design new learning strategies, explore teaching methods, and develop skills through digital education. Particularly in medical education, early hands-on training is vital for the development of clinical skills. Remote simulations pose an innovative opportunity to encourage reflection on performance and transfer knowledge towards a demonstrable experience. The objective of this study was to develop and assess a remotesynchronous simulation experience. The study considered a quantitative approach with a descriptive and cross-sectional design. The sample consisted of 54 fourth-year medical students enrolled in a distance course on respiratory pathophysiology. The strategy was implemented through remote-synchronous simulations of 90 minutes using a videoconference platform. Students experienced the images, sounds, voices, and tension of an emergency room setting. The process considered 3 phases: 1)Design 2) Implementation 3)Reflective moment. To assess the experience, students were asked to participate in a survey with a 5-point Likert scale, where 5 depicts a more favorable response. Results show that students believe adapting to the remote-simulation was easy (3.92), and participating in the innovation was satisfactory for them (4.70). This remote-synchronous simulation of an emergency room for medical students provided a significant learning experience and a space for reflection that was highly valued for students. It is essential to highlight that it was easy to implement for the faculty members, and it was a low-cost alternative to offer early training experience amid the pandemic. This model may be transferable for other contexts and professions to enrich training in blended-learning formats. Keywords: Educational innovation, medical education, remote-simulation, pandemic adaptations, distance learning
DESIGN AND EVALUATION OF A MOOC FOR CLINICAL EDUCATORS
Authors:   Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico, Olivares-Olivares SL , Turrubiates-Corolla ML ,   Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico, EsperónHernández RI ,   Universidad Westhill, Facultad de Medicina, Mexico, Sánchez-Mendiola M ,   Universidad Nacional Autónoma de México, Facultad de Medicina, Mexico
Published: September 2021

The MOOCs offer education with high quality standards and have the potential to offer better educational experiences within learning communities where students and teachers from multiple institutions and areas participate. Clinical professors need to be continuously trained with new alternatives that reduce the gap of traditional education with the needs of students. In addition, it is essential to move from education focused exclusively on science, towards a comprehensive education focused on the needs of the most important actor: the patient. The purpose was to design, implement, and evaluate a MOOC on educational evaluation in health sciences. The content of the MOOC was designed and developed with the participation of 15 professors from three universities in Mexico. A pilot was implemented during September-October 2019 to train at least 30 teachers from the three universities. An instrument was designed to measure the fulfillment of teachers' expectations. The pre-test was applied before starting the pilot course and the post-test at the end of the program. The tests were answered by 29 of 57 professors, whose data were analyzed using the t-student statistical test. The course was successfully completed by 33 of 57 teachers. The results of the statistical test show that there is a significant difference. The expectations of the teachers who completed the course were exceeded. For the educational proposal to be considered valuable, it must consistently meet the participant's learning needs according to the effort and cost invested. Knowing the perceived value indicates how participants conceive the value of the program. In this sense, MOOCs represent opportunities for teacher training in educational evaluation. The project has great potential for impact at the Latin American level. Keywords: MOOC, clinical teachers, health sciences, clinical competence, patientcentered learning, educational innovation
DEVELOPMENT OF CASE STUDIES TO IMPROVE ATTITUDINAL ENTREPRENEURSHIP COMPETENCIES: AN EXPERIMENTAL STUDY WITH STUDENTS FROM TEC DE MONTERREY
Authors:   EGADE Business School and Tecnológico de Monterrey, Mexico, Granados C , Tena V ,   EGADE Business School and Tecnológico de Monterrey, Mexico, Tame JA ,   EGADE Business School and Tecnológico de Monterrey, Mexico, Mendiola C ,   EGADE Business School and Tecnológico de Monterrey, Mexico
Published: September 2021

The way in which entrepreneurship is taught has a high impact on students' entrepreneurial capacity. In this sense, there have been several studies that analyze the impact that different forms of teaching have on the development of entrepreneurship skills. Different research indicates, in a general sense, that the more education concerning entrepreneurship, the more entrepreneurship skills are developed. Other studies report that students that were involved in a more practical and reflective educational model, reported greater intentions of undertaking an entrepreneurial experience. However, none of these studies use the development of “case studies” as a means of developing entrepreneurship skills. In this sense, this research project proposes an experimental study, with a control group of 30 students and three intervention groups of 90 students (from fifth semester forward), in order to measure the impact that the development of real entrepreneurs case studies (either of success or failure) had on students. All of this, in order to improve the attitudinal competencies of: (i) problem analysis mentality before proposing early solutions, ii) mentality of testing low-cost solutions before investing, and (iii) data-driven decision-making mentality rather than intuition. Results suggest that there were noticeable improvements in the soft skills learned by the students. There was a percentage change in the results of the intervention groups in comparison with the control group (even when the control group also registered improvements). Further studies may test this intervention in different settings or measure other soft/hard skills using the same intervention. Keywords: educational innovation, higher education, entrepreneurship, competencies, experiential learning, case studies
Trends in antibiotic consumption in Colombian intensive care units, 2010-2017 v1
Authors: Machado Alba Jorge
Published: September 2021

Trends in antibiotic consumption in Colombian intensive care units, 2010-2017 Introduction: Antibiotics are frequently used in intensive care units (ICUs). The objective of this study was to describe the trends of antibiotic use in Colombian ICUs across 8 years. Methods: This was a descriptive study that analyzed the consumption of antibiotics in 11 ICUs in 7 different cities. Patients older than 18 years in the period 2010 to 2017 were included. Demographic, pharmacological and cost variables were analyzed. Results: A total of 31,886 patients (50.8% men), with a mean age of 60.3±19.8 years, were treated with antibiotics. The most widely used antibiotics were piperacillin-tazobactam (25.2%), ampicillin-sulbactam (21.8%), and vancomycin (21.4%). The use of cefepime increased from 5.7 defined daily doses per 100 bed-days (DBD) in 2010 to 11.3 in 2017, followed by the use of meropenem (14.73 to 20.18 DBD). The average cost per patient/day decreased from USD 16.1 to USD 8.0 (reduction of 50.3%). A total of 41.3% of the cost corresponded to meropenem and 25.8% to piperacillin-tazobactam. Conclusions: The antimicrobials used in the ICU correspond to those recommended by the clinical practice guidelines. An increase in the DBD of some cephalosporins, carbapenems and penicillins and a significant reduction in the cost per patient day were observed.
Effect of postoperative coffee consumption on postoperative ileus after abdominal surgery: An updated systematic review and meta-analysis (protocol) v1
Authors: Watanabe Jun , Miki Atsushi , Kotani Kazuhiko , Sata Naohiro
Published: September 2021

Introduction: Coffee, a popular and cheap beverage worldwide, may have an important effect on postoperative ileus (POI). However, previous systematic reviews have not clarified whether the effect is due to caffeine or coffee itself, or shortening hospital stay. We will aim to assess the effect of postoperative coffee consumption on POI. Methods: Studies evaluating the effect of postoperative coffee consumption will be searched using the electronic databases and the trial registries. Meta-analyses will be performed using random-effects models. The Grading of Recommendations, Assessment, Development, and Evaluation approach will be used to assess the certainty of evidence.