bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness
Authors: Wang Chun-I , Kao Huang-Kai , Chen Ting-Wen , Huang Yenlin , Cheng Hsing-Wen , Yi Jui-Shan , Hung Shao-Yu , Wu Chi-Sheng , Lee Yun-Shien , Chang Kai-Ping
Published: July 2019

Background

DNA copy number variations (CNVs) are a hallmark of cancer, and the current study aimed to demonstrate the profile of the CNVs for oral cavity squamous cell carcinoma (OSCC) and elucidate the clinicopathological associations and molecular mechanisms of a potential marker derived from CNVs, mixed-lineage leukemia translocated to chromosome 3 protein (MLLT3), in OSCC carcinogenesis.

Materials and Methods

CNVs in 37 OSCC tissue specimens were analyzed using a high-resolution microarray, the OncoScan array. Gene expression was analyzed by real-time polymerase chain reaction in 127 OSCC and normal tissue samples. Cell function assays included cell cycle, migration, invasion and chromatin immunoprecipitation assays.

Results

We found a novel copy number amplified region, chromosome 9p, encompassing MLLT3 via the comparison of our data set with six other OSCC genome-wide CNV data sets. MLLT3 overexpression was associated with poorer overall survival in patients with OSCC (p = .048). MLLT3 knockdown reduced cell migration and invasion. The reduced invasion ability in MLLT3-knockdown cells was rescued with double knockdown of MLLT3 and CBP/p300-interacting transactivator with ED rich carboxy-terminal domain 4 (CITED4; 21.0% vs. 61.5%). Knockdown of MLLT3 impaired disruptor of telomeric silencing-1-like (Dot1L)-associated hypermethylation in the promoter of the tumor suppressor, CITED4 (p < .001), and hence dysregulated HIF-1α-mediated genes (TWIST, MMP1, MMP2, VIM, and CDH1) in OSCC cells.

Conclusion

We identified unique CNVs in tumors of Taiwanese patients with OSCC. Notably, MLLT3 overexpression is related to the poorer prognosis of patients with OSCC and is required for Dot1L-mediated transcriptional repression of CITED4, leading to dysregulation of HIF-1α-mediated genes.

Implications for Practice

This article reports unique copy number variations in oral cavity squamous cell carcinoma (OSCC) tumors of Taiwanese patients. Notably, MLLT3 overexpression is related to the poorer prognosis of patients with OSCC and is required for Dot1L-mediated transcriptional repression of CITED4, leading to dysregulation of HIF-1α-mediated genes.
Las vías de hecho estudiantiles y los derechos a la defensa y el debido proceso del profesorado universitario
Authors: Ulrich Astaiza William Eugene , Campo Baena Ingrid Jimena
Published: June 2019

Introducción: en las relaciones del estudiantado universitario tanto en el ámbito público como en el privado a menudo se presentan inconformidades, bien sea metodológicas o bien personales, que ponen en evidencia la debilidad de los sistemas educativos de categoría universitaria en cuanto al manejo de conflictos y su oportuna resolución. Esto ha creado procedimientos de facto como el “veto que se torna en una vía de hecho”.

Objetivo: determinar por medio de la jurisprudencia y la ley un procedimiento disciplinario jurídico obediente a los derechos fundamentales que rija las diferencias del estudiantado con el profesorado y viceversa.

Metodología: mediante el análisis de la jurisprudencia de la Corte Constitucional y de la aplicación de procedimientos determinados en la ley colombiana se buscará hacer una propuesta de procedimiento viable para resolver las diferencias que surgen entre el estudiantado y el profesorado.

Resultados: se propone una forma de juicio que permita, de acuerdo con los manuales de convivencia o reglamentos disciplinarios existentes, ejercer la defensa, la contradicción, la presentación y la práctica de pruebas, además del derecho a un veredicto en condiciones de imparcialidad e igualdad con la opción de presentar los recursos que se estimen necesarios.

Conclusiones: se anima a los profesores y estudiantes universitarios a plantear este tipo de situaciones en sus reuniones internas, de modo que se genere discusión, a fin de lograr un consenso que permita la visibilización de este problema y que, claro está, se busquen soluciones jurídicas a ellos a fin de evitar que este tipo de situaciones se perpetúen como mecanismo de acción de facto.
Analysis of the influence of cold pipe rolling technological factors on the change in Q-factor distribution along the deformation cone
Authors: Pilipenko S. V.
Published: July 2019

The paper provides the results of studying the effect of technological factors of the cold pipe rolling process on the changingof Q-factor distribution along the deformation cone. The Q-factor value, which is the relationship between actual deformation on the wall thickness and actual deformation on the pipe mean diameter, and the pattern of its distribution along the deformation cone are controlledvalues when rolling pipes from titanium and zirconium alloys of a certain range. The Q-factor defines whether metal grains will be oriented radially or tangentially. It is desirable that Q-factor f luctuate around its definite value with low amplitude along the entire deformation cone. It is determined that the method used to calculate the pipe wall thickness distribution along the deformation cone has a significant effect on the change in the Q-factor distribution along the deformation cone. The advantages of using mandrels with a curvilinear generatrix of the working surface profile are confirmed. Dependences ascertained in the article can be used to calculate the schedules of rolling and calibration of cold pilgering mill tools.
11th International Symposium «Powder Metallurgy: Surface Engineering,New Powder Composite Materials, Protective Coatings.Welding»
Authors: Editorial Article
Published: July 2019

April 10–12, 2019, Minsk, Belarus
Nihongo Speech Trainer: A Pronunciation Training System for Japanese Sounds
Authors: Trakantalerngsak Tanporn
Published: June 2019

This article will present the methodology, as well as the results, of a pilot study of the ‘Nihongo Speech Trainer’ aimed at helping Thai learners improve their ability to identify Japanese contrasts. The pilot study was performed on 15 participants. The tool focuses on specific contrasts that are problematic for Thai learners such as Japanese fricatives and affricates. Perceptual training uses a high-variability phonetic training method (hereafter referred to as “HVPT perceptual training”). Each training session included 90 minimal pairs in which the target contrasts were embedded in initial, medial and final positions. The training stimuli were produced by seven Japanese native speakers. The results of the pilot study showed that the use of the Nihongo Speech Trainer can lead to better perception of the trained Japanese sounds. The results of a questionnaire among the participants also showed that the system helped to improve their perception and production ability. However, despite these positive results with the use of the Nihongo Speech Trainer, there is room for improvement, which may lead to better training results.
Efforts to transform Heterosigma akashiwo using an Agrobacterium-mediatedapproach v3
Authors: K Nagarajan Vinay , Accerbi Monica , J Green Pamela
Published: June 2019

This protocol was developed for transformation of Heterosigma akashiwo byAgrobacterium tumefaciens.H. akashiwodoes not grow on solid medium, so transformants are grown "in bulk" and should not be considered clonal. We have had limited success with this protocol and mayrequire further optimization.
PERAN RELIJIUSITAS DALAM MENINGKATKAN NIAT MEMBELI PRODUK ASURANSI MIKRO SYARIAH
Authors: Hamdan Firmandhani
Published: July 2019

This study describes the factors which affecting micro society’s intention on purchasing sharia micro insurance. Taking sample at the Koperasi Baytul Ikhtiar Bogor where the entire financing for its participants already protected by sharia credit insurance. This research uses descriptive quantitative approach based on study literature, observation, and quetionaire using the method of  Partial Least Square (PLS) yang which the alternative method of Structural Equation Modeling (SEM). The variable consist of intention as dependent variable and Religiousity with Islamic belief and practice dimension as Independent variable. From these Islamic practice has more affect the micro society’s intention to purchase sharia micro insurance than Islamic Belief.Keyword: micro insurance, sharia micro insurance, religiousity, TPB, SEM PLS
İlköğretim Matematik Öğretmen Adaylarının Lisans Eğitiminde Alınan Matematik Konu Alan Derslerine İlişkin Görüşleri
Authors: GENÇ Murat , AKINCI Mustafa
Published: July 2019

Bu
araştırmanın amacı, ilköğretim matematik öğretmenliği programında öğrenim gören
öğretmen adaylarının matematik konu alan derslerine ilişkin görüşlerini
belirlemektir. Bu araştırma nitel araştırma desenlerinden biri olan olgu bilim
deseni kapsamında yürütülmüştür. Çalışmanın araştırma gurubunu oluşturan 43
matematik öğretmen adayı seçiminde bir amaçlı örnekleme yöntemi olan ölçüt
örnekleme yönteminden yararlanılmıştır. Veri toplama aracı olarak açık uçlu bir
anket formu uygulanarak öğretmen adaylarının görüşleri yazılı olarak
alınmıştır. Veri analizi nitel veri analizi yazılımı olan NVivo 11 yardımıyla
içerik analizi yöntemi kullanılarak gerçekleştirilmiştir. Araştırmanın
sonuçları, lisans matematik derslerinin, öğretmen adaylarının matematiksel
becerilerinin genel gelişimine odaklanması gerektiğini ve sadece konu alan
bilgisinin aktarılması yerine, kavramsal ilişkileri kurmak için dikkatli bir
akıl yürütme ve matematiksel sağduyu geliştirerek matematiğin derinlemesine
anlaşılmasının gerekliğini ortaya çıkarmıştır. Ayrıca, diğer matematiksel
kavramlar ve gerçek yaşam durumlarıyla ilişkili geniş kapsamlı ve detaylı
matematiksel konu alan bilgisinin öğretimi, öğretmen adaylarının matematik
derslerine yönelik motivasyonlarını artıracak ve öğretilen matematiği daha
anlamlı kılacaktır.
Strategies to combat on the resurgence of leprosy: Points to be emphasized
Authors: VENKATESAN Sajitha , THANGARAJU Pugazhenthan
Published: July 2019

COMMENT TO A WORLD REPORT PUBLISHED
Del marketing tradicional al marketing de liberación
Authors: Filgueiras Nodar José María
Published: July 2019

Este artículo presenta una descripción (en sentido rortiano) del marketing capaz de hacer frente a las principales críticas que se lanzan contra el mismo. Se comienza haciendo un repaso de dichas críticas, para posteriormente analizar tres variedades empresariales en las cuales el marketing tradicional contribuye al logro de beneficios sociales: las cooperativas, las empresas sociales y las empresas de base comunitaria. Luego, se presenta el marketing social, cuyo principal objetivo es difundir ideas beneficiosas para toda la sociedad. Después se introduce el ‘marketing de liberación’ propiamente dicho, encaminado a liberar a los consumidores de ciertas prácticas negativas del propio marketing. El texto finaliza con unas reflexiones que tratan de poner en relación el enfoque aquí presentado con los conceptos de emancipación y alienación.
Branding en la fidelización de clientes de Starbucks en la ciudad de Guadalajara
Authors: Aguilar Pérez Pedro , Cruz Covarrubias Lucila Patricia , Aguilar Cruz Pedro Daniel , Garza Estrada Rosalinda
Published: July 2019

El poder de una marca sobre los públicos, ha sido últimamente tema de estudio, dada la incidencia que esta ejerce sobre el comportamiento de compra y consumo de productos y servicios. De allí nace la aplicación del branding emocional herramienta adecuada para posicionar a la compañía a través de las emociones y lograr la fidelización de sus clientes. El propósito del presente trabajo es exponer si esta herramienta de gestión de marca influye en la fidelización de los clientes de Starbucks en la ciudad de Guadalajara. Se optó por el método cuantitativo, empleando la técnica de la encuesta y utilizando como instrumento un cuestionario en una muestra representativa conformada por 329 clientes. Los resultados nos permitieron explicar la influencia del branding emocional positivamente en la fidelización de los clientes.
La reparación en casos de violencia de género en Ecuador. Apuntes preliminares sobre los desafíos de los Centros de Atención = Reparation in the Area of Gender-Based Violence in Ecuador. Preliminary Notes on the Challenges of Care Centers
Authors: Guarderas Albuja Paz , Verdú Delgado Ana Dolores , Carrión Berrú Celsa Beatriz , Gordillo Placencia Lucianne Anabel
Published: July 2019

ResumenEn el 2018 entró en vigencia en Ecuador una nueva ley de erradicación de la violencia de género que enfatiza la reparación. En este artículo nos proponemos indagar en las concepciones en torno a la reparación en la normativa nacional, así como evidenciar las transformaciones en la atención a las víctimas de violencia de género en el país. El análisis se orienta al objetivo de identificar los obstáculos y desafíos que presenta la aplicación de la nueva ley a nivel local. Como conclusión se señala la necesidad de una mayor institucionalización de los procesos de reparación de las víctimas en un contexto en el que estos recaen principalmente sobre organizaciones no gubernamentales con escasos recursos o gobiernos locales.AbstractIn 2008, a new law for eradicating gender-based violence takes effect in Ecuador, with a new emphasis on reparation. In this paper we aim to review the conceptions regarding reparation in national norms, as well as highlighting the transformations on the attention on the victims of gender-based violence in the country. Analysis is guided by the objective of identifying the obstacles and challenges present in the implementation of the new law at local level. As a conclusion we point out that need for a greater institutionalization of the processes of victims reparation in a context in which these processes lie mainly with non-governmental organizations with scant resources or local governments.
Impacto de la concentración de suero fetal bovino sobre las células epiteliales dentales
Authors: Simancas Escorcia Victor , Diaz Caballero Antonio
Published: July 2019

El esmalte dental, tejido más duro del cuerpo humano, es formado por medio de la diferenciación de células epiteliales conocidas como ameloblastos. Recientemente, las células epiteliales dentales de incisivo de rata han sido utilizadas como modelo celular de eventos fisiopatológicos durante la formación del esmalte dental. Sin embargo, en función de los eventos estudiados es meritorio comprender su comportamiento, particularmente cuando la concentración del Suero Fetal Bovino (SFB) varia. El propósito de este trabajo es evaluar el impacto de la concentración del SFB sobre el crecimiento, proliferación y supervivencia de las células epiteliales dentales. Células epiteliales dentales fueron cultivadas en DMEM/F12, en presencia y ausencia de SFB. Observaciones morfológicas e inmunohistoquímicos de la actina, vimentina y fibronectina fueron realizados. Los resultados permitieron constatar que la ausencia de SFB afectó negativamente la proliferación de las células epiteliales dentales, pero mantuvo una expresión optima de la actina y vimentina. Se identificó una alteración en la expresión de la fibronectina en las células tratadas en ausencia de SFB. En conclusión, la carencia de SFB disminuyo drásticamente la supervivencia, proliferación y expresión de la fibronectina en las células epiteliales dentales de rata.
Comparative study to evaluate the efficacy and safety of oral Mifepristone versus intracervical Dinoprostone gel for induction of labour and their effects on fetomaternal outcome
Authors: Pathak Anu , Singh Saroj , Singh Shikha , Kumar Rajesh , Tyagi Arpita
Published: June 2019

Background: Mifepristone and Dinoprostone are used in inducing labour in pregnancy by acting as cervical ripening drugs. A randomized case control study to evaluate the efficacy, safety and fetomaternal outcome of induction of labour with oral Mifepristone and intracervical Dinoprostone gel was done.Methods: About 300 patients were included after taking informed consent. 150 patients were placed in each group A and B. In group A patients received 200 mg oral Mifepristone tablet and in group B 0.5 mg Dinoprostone gel was given intracervically and 2nd dose was repeated after 6 hours later if adequate uterine contractions were not achieved. A detailed analysis was carried out in both groups regarding efficacy and safety of drugs in terms of necessity of augmentation of labour with oxytocin, induction to delivery interval, fetal outcome in terms of NICU admission.Results: 59.33% cases in Mifepristone group and 72% case in Dinoprostone group required augmentation with oxytocin. Mean induction delivery interval in Mifepristone group in primigravida was 17.998±1.128 hrs and mean induction delievery interval in multigravida was 11.648±1.112 hours. 88% cases in mifipristone group and 80% cases in Dinoprostone group delivered vaginally. NICU admission was 1.33% in Mifepristone group and 2.66% in PGE2 gel group.Conclusions: Mifepristone when compared with intracervical Dinoprostone gel, acts as a better cervical ripening agent and requires lesser need for Oxytocin augmentation. Though, mean induction delivery interval was more with Mifepistone, the incidence of successful vaginal delivery was higher as compared to Dinoprostone.
Gynecological problems and reproductive health awareness amongst late adolescent girls pursuing professional courses: a questionnaire based survey
Authors: Chennuru Rambabu , Begum Jarina
Published: June 2019

Background: Dysmenorrhoeais a debilitating menstrual problem and may be related to body mass index (BMI). This study was done to explore the various gynecological problems in girls in their late adolescence that is pursuing professional courses in medicine, dental and nursing.Methods: This was a prospective, questionnaire based study conducted between January and February 2019 in a medical college in Visakhapatnam, India. The survey included female undergraduate students of the Medical, Dental and Nursing colleges to find out their menstrual history and reproductive awareness with the help of a self-structured questionnaire. Participants were categorized based on BMI. Data was reported as number and percentage.Results: Of the 190 participants, 154 participants (age range; 16-19 years) were included in the study. Fifty percent of the total participants reported to have dysmenorrhoea, of which 21% reported severe dysmenorrhoea. A very high % of participants in the obese category (77.8%) reported severe dysmenorrhoea, followed by 27.3% in the underweight category. A U-shaped relationship between percentage of participants with severe dysmenorrhoea and increasing BMI was observed. A fair percentage of obese participants reported for infrequent periods beyond 35-45 days and androgenic features like excess hair, acne and dark pigmentation around neck, suggestive of polycystic ovarian syndrome (PCOS). The participants possessed a high level of awareness and reported in the range of 87.1 to 96.8% related to reproductive health.Conclusions: Despite high level of awareness among the participants we observed a considerably high prevalence of dysmenorrhoea which was even more prevalent, in the obese category.
Cases of management of paediatric tubo-ovarian torsion
Authors: Bhandari Ruchi , Khemani Manju , Mustafa Asif
Published: June 2019

Ovarian torsion is the fifth most common cause of gynaecologic surgical emergency. It warrants early diagnosis as timely surgical management will avoid the further adnexal injury. In paediatric population, this is especially dangerous as the condition can go undiagnosed because of its rarity and nonspecific presentation. This leads to delay in surgical exploration and loss of ovarian function. In these cases, the ovary and often the ipsilateral fallopian tube twist with the vascular pedicle, resulting in vascular compromise. Unrelieved torsion leads to haemorrhagic infarction. We encountered 3 cases of ovarian torsion in paediatric age group during a period of 12 months. All cases presented with acute pain abdomen for 3-7 days period with loss of appetite and unable to pass motion with varied disappearance of pain. On ultrasound all the cases were diagnosed with ovarian cyst with torsion and underwent laparoscopic cystectomy. This case series is written just to show the results of de-torsion and conserving the fallopian tube and ovary after vascular damage. This type of conservative management may give chance to ovary to return to viability. This was seen in all 3 cases dealt by us on repeat scan on follow up. Even on de-torsion if ovary does not regain its colour immediately it should be conserved, and cystectomy should be performed rather than oophorectomy. Conservative surgery, in the form of ovarian de-torsion can be tried in cases of ischemia but if ovarian necrosis has occurred, then salpingo-oophorectomy is performed as the last resort.
Comparative study between laparoscopic common bile duct exploration and endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy for choledocholithiasis
Authors: Salem Mohamed Mohsen , Esmat Mohamed Emad , Hassan Ahmed Mohamed Abdelaziz , Amer Yaser , Abdelaziz Hisham , Rady Mahmoud
Published: June 2019

Background: Endoscopic retrograde cholangiopancreatography (ERCP) with consequent laparoscopic cholecystectomy (LC) has been the favored approach for the treatment of choledocholithiasis for a long time; however recently, laparoscopic common bile duct exploration (LCBDE) has been offered to patients with suspected choledocholithiasis. Objective and aim of this work was to compare the efficacy, safety, and the surgical outcomes of LCBDE with ERCP followed by LC and determine the most appropriate approach for patients with choledocholithiasis.Methods: A prospective clinical study was carried out from March 2017 to September 2018. It included 50 patients with cholecysto-choledocholithiasis who were divided into two groups: group A (25 patients) included patients who underwent transcystic LCBDE and stone extraction with LC in one stage, and group B (25 patients) included patients who underwent ERCP followed by LC in two stages. The common bile duct (CBD) stone clearance rate, postoperative bile leakage, postoperative morbidity, mortality, overall hospital stay, and patient satisfaction were analyzed.Results: LCBDE and ERCP+LC were similar in terms of clearance rate, operative time, postoperative complications, retained CBD stones, and postoperative length of stay, but there was a significant difference in number of procedures and patient satisfaction.Conclusions: Although both approaches have equivalent success rates, LCBDE is better in terms of fewer procedures, and better satisfaction compared with ERCP + LC. Our study suggests that one-stage management is the treatment of choice for patients with cholecysto-choledocholithiasis.
Mesh fixation versus non fixation in open herrnioplasty
Authors: Elkasem Hossam Abd Ellatif Abo , Aldardeer Ahmed Abdelkahaar
Published: June 2019

Background: The goal of this study was to compare herrnioplasty with or without mesh fixation for inguinal hernias, paraumbilical hernia and epigastric hernia.Methods: This study included 288patients (170 males and 118 females) of different age groups with hernia  who were admitted to general surgery department of sohag university hospital during the period from April 2018 to march 2019. Analysis of the clinical presentation, type of hernia and patients risk factors was done. All patients with above mentioned hernias without history of previous operations, was eligible for the study.Results: A total of 288 patients, 123 patients (42.7%) had oblique inguinal hernia, 75 patients (26%) had epigastric hernia, 77 (26.7%) had Para umbilical hernia and 13 (4.5%) had direct inguinal hernia. We had two groups, group (I) with mesh fixation included 141 patients (49%), while group (II) included patients (51%) without fixation of the mesh. Methods of fixation of the mesh in group (I) included suturing in 94 patients (32.6%), while using staples in 47 patients (16.3%). From 288 patients, 26 patients (9%) were hypertensives, 13 patients (4.5%) were diabetic and 13 patients (4.5%) were smokers. Follow up period extended for eight months post operatively, patients without fixation to their mesh had less pain and infection.Conclusions: Herrnioplasty can be carried out either with fixation of the mesh or not, it will not affect recurrence of the hernia and has less cost and operative time.
Anatomical variations of the inguinal morphometric features in patients with inguinal hernia and its association with the type of inguinal hernia: a prospective clinical study
Authors: Anitha Balaiya , Sureshkumar Sathasivam , Aravindhan Karuppusamy , Ali Manwar
Published: June 2019

Background: Variations of inguinal canal and inguinal nerves are not uncommon. Knowledge about those variations is important to avoid inadvertent injury to the vital structures and to prevent recurrence.Methods: This prospective clinical study included all patients undergoing open inguinal hernia repair. Laparoscopic hernia repair, emergency surgery for complication and recurrent inguinal hernia were excluded. Parameters studied include interspinous distance, length and obliquity of inguinal ligament, attachment of conjoint tendon, condition of transversalis fascia and position and variations of ilioinguinal nerve.Results: The study included 192 patients. The mean interspinous distance (ISD) was 22±3.45 cm (CI: 30-32). ISD was not significant different among the two types of hernia. The mean length of internal oblique on inguinal ligament from anterior superior iliac spine was significantly longer in patients with indirect inguinal hernia (4±0.791 vs. 4.27±1.34; p=0.000). Significant patients in the direct hernia had weak transversalis fascia ((95% vs. 43%). 80% of the patients with direct hernia had defect in the transversalis fascia compared to only 8.8% in the indirect hernia. The difference is statistically significant. The nerve variation was present in only 1.3% in direct hernia group compared to 3.5% in the indirect hernia group.Conclusions: It was observed that the type of hernia did not significantly influenced by the length of inguinal ligament, the mean distance of midinguinal point, obliquity of the inguinal ligament. The nerve variation was present in only 1.3% in direct hernia group compared to 3.5% in the indirect hernia group.
Pancreatico-biliary pathologies: correlation of USG and MRCP
Authors: Khopde Priyanka Ashok , Kelkar Abhimanyu , Joshi Priscilla , Bandgar Amol , Mahajan Mangal
Published: June 2019

Background: Obstructive jaundice is the most frequent form of hepato-biliary pathologies. The main aim is to confirm the presence of obstruction and to identify its cause, location and extent of the lesion. This study evaluated the role of USG and MRCP in hepato-biliary pathology.Methods: Twenty-five patients of all age groups with suspicion of obstructive jaundice referred for Ultrasound were included in our study. The patients with findings suggestive of biliary obstruction underwent MRCP.Results: Out of 25 patients, maximum patients were in the age group of 61-80 yrs. 52% were male and 48% were female. The jaundice was due to a benign etiology in 64% patients and malignant etiology in 36%. The most common benign pathology was choledocholithiasis (25%) and malignant pathology was periampullary carcinoma (44%). Overall 11 cases were inconclusive on ultrasound study while 2 cases were false positive for malignancy on MRCP. In 92% cases the correct diagnosis was detected on MRCP.Conclusions: USG is the initial and sometimes the only imaging modality in obstructive biliary disease. However the distal CBD which is poorly seen on USG can be well evaluated on MRCP thus improving the diagnosis in pancreatico-biliary pathologies.
Management and outcome of lower limb varicose veins: a hospital based follow up study
Authors: Reddy G. V. Ramana , Abhilash V. , Harshavardhan Y. , Ravikiran B.
Published: June 2019

Background: Disorders of veins which are chronic in nature and very common are the varicose veins. Surgery is required at any one stage of the disease. There have been considerable advances that took place in the diagnostics of the varicose veins, but the treatment outcomes may not be good in many cases. To study the management and outcome of lower limbs varicose veins.Methods: This was a hospital based follow up study. Patients who presented with varicose veins signs and symptoms were included. During the study period it was possible to include 40 patients who were willing to get included in the present study. Various presentations, complications and treatments were noted and finally followed up for minimum of 3 months.Results: Most commonly affected age group was 36-45 years. Males were four times more affected than females. Most commonly affected limb was left side in 48%. Long saphenous system was involved in 55%. The predominant symptom was dilated and tortuous veins (32%) followed by pain (25%). 65 incompetent perforators identified by clinical examination and 130 by Doppler with above ankle being the commonest incompetent perforator. With the mean follow up of six months, no serious complications were noted. It was found that the sensitivity of the clinical examination was 82% when doppler scan was taken as gold standard. On follow up no one developed deep vein thrombosis. Incompetence recurrence rate at SFJ was 8% and at SPJ was 18%.Conclusions: We conclude that surgery is the first line of management and if done accurately, complications are minimal.
Poezja, muzyka i sumienie. O Lukanie w Koronacji Poppei Giovanniego Francesco Busenellego i Claudio Monteverdiego
Authors: Puchalska Iwona
Published: July 2019

The article discusses the role of Lucano in the dramatic structure of The Coronation of Poppaea. After a deeper analysis, the poet, an episodic figure, turns out to be an important element in the reconstruction of the ideological background of the works by Busenello and Monteverdi. This is achieved by context reading of the opera libretto in two fundamental aspects – biographical and literary, based on two groups of textual sources related to Lucano – the first consisting of information about his life and work, and the second, which is his own works. Particular attention was paid to the analysis of Farsalia, a poem that shows numerous ideological affinities to Busenello’s libretto. A detailed analysis of literary contexts also reveals the self-thematic aspect of the scene with Lucano’s participation and the moral aspects of poetic creation that emerge in connection with it.
Oświeconych nie trzeba oświecać… Refleksje o szkole, powadze czytania i szaleństwie ideologii
Authors: Zając Grzegorz
Published: July 2019

Pointing to the progressive marginalization of the Enlightenment literature in the Polish language curricula implemented in secondary schools over the last several years, the author focuses on the related phenomenon of biased reception of that literature, dominated by stereotypes and simplifications. The author asks how the 18th and early-19th-century texts should be read – with the aim of restoring their proper rank in the cultural tradition – to perceive them not only in the historical and social context, and thus not to reduce their meaning to a didactic or political message. In the face of the disturbing trends in the field of literary studies, which instrumentalise a literary work, the author also stresses the need to avoid a situation in which the ideological beliefs of the researcher projected on an older text seem to dominate it, distorting its image.
Dlaczego preromantyzm? Literatura przełomu XVIII i XIX stulecia w terminologii historyka literatury
Authors: Pluta Paweł
Published: July 2019

The article is an attempt to look at the meaning of the term “pre-Romanticism” through the prism of its functioning in literary texts. The subject of analysis are texts published in two book by Alina Aleksandrowicz and Ewa Grzęda. The two books are different in terms of the date (1991 and 2007) and the nature of the publication (collective volume and author’s anthology of literary works), but also linked to each other through the use of the term pre-Romanticism in their titles. The reconstructed senses of the term pre-Romanticism refer to aesthetic and literary phenomena which have their specific names in literary studies: Sentimentalism, Gothicism, Ossianism or Rococo. The observations of other literary researchers (T. Kostkiewiczowa, A. Kowalczykowa, J. Krzyżanowski, Z. Libera, J. Lyszczyna, J. Maciejewski), who previously considered the problem of pre-Romanticism, constitute a complementary or comparative material for the formulated conclusions.
Diffusiontensor MRI tractography in patients with children’s cerebral palsy: assessment of structural lesions of conduction tracts
Authors: Ermolina Yulia V. , Namazova-Baranova L. S. , Mamedyarov A. M. , Anikin A. V. , Maslova O. I.
Published: July 2019

Introduction. The application of diffusion-tensor (DT)-MRI tractography in patients with children S cerebral palsy (CP) allows to establish pathophysiological mechanisms of the development of motor and sensory impairments, to perform a clinical and neuroimaging comparison, as well as to determine correlations between lesions of the conduction tracts and neurological deficits. Aim. For the determination of changes in fractional anisotropy (FA) and mean diffusivity coefficient (MDC), obtained with DT-MRI in the corticospinal and sensory tracts, structures of the corpus callosum in spastic forms of CP. Materials and methods. There were examined 105 children with spastic forms of CP (spastic tetraparesis - 47, spastic diplegia - 38, hemiparetic form - 20) and 50 children without neurological deficit, at the age of 2-18 years. In all CP patients the severity of motor deficit was evaluated according to Gross Motor Function Classification System (GMFCS). DT-MRI was performed in all cases with the use of devices of General Electric (US), under magnetic field strength of 1.5T and 3T, with the calculation of the FA and the MDC in areas of interest - cerebral peduncles the brain stem, the posterior limb of the internal capsule, the genu and splenium of the corpus callosum, posterior thalamic radiation, postcentral gyrus, the thalamus. Results. There was established the distribution of children according to the GMFCS scale: I - 14 (13,4%), II - 19 (18,1%), III - 20 (19%), IV- 10 (9,5%), V- 42 (40%) cases. The severity of motor impairment on the GMFCS scale closely correlated with the values of FA and ADC in cerebral peduncles, posterior limb of the internal capsule, posterior thalamic radiance, genu of the corpus callosum. Conclusion. DT-MRI enables to assess adequately the changes in the white matter of the brain, structural andfunctional state of the motor and sensory conduction tracts, gives a possibility to predict the development of a child with CP.
The profile of cytokines in adolescents with pollinoses
Authors: Balabolkin I. I. , Bulgakova Vilya A. , Smirnov I. E. , Belyaeva E. V. , Botvinyeva V. V. , Filyanskaya E. G.
Published: July 2019

The formation of hay fever as a form of allergic pathology in children is determined by the sensitization of the growing organism to pollen allergens with the production of specific IgE and significant influence of atopy. Comprehensively there were examined 45 adolescents of 10-17 years, suffering from hay fever. Serum cytokine content was determined by ELISA. Adolescents suffering from hay fever, in the remission of the disease were established to show an increase of production IL-4, IL-5, IL-10, IL-12, accompanied by an increase in total serum IgE level. It indicates to the prevalence of Th2-immune response and participation of atopy in their development. The elevation of the IL-12 serum level in adolescents suffering from hay fever, more pronounced in patients with chronic inflammatory pathology of the upper respiratory tract, is possibly aimed at the reinforcement of the synthesis of IFN-a and suppression of the excessive Th2- immune response. The development of Th1/Th2 imbalance with predominance of Th2 immune response and changes in the cytokine status in examined adolescents are the determining factors for the occurrence of diseases due to pollen sensitization in them. The study of the assembly of various cytokines in pollenoses permits to destine about the functional activity of various cells of the immune system, the severity of the allergic process, the degree of activation of Th2 and Th1 lymphocytes, which should be considered in the treatment of these forms of allergic diseases in children.
Serum calprotectin, C-reactive protein and procalcitonin in preterm infants with necrotizing enterocolitis
Authors: Shishkina Tatyana N. , Smirnov I. E. , Kucherenko A. G. , Kucherov Yu. I. , Rekhviashvili M. G.
Published: July 2019

Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in preterm infants. The development of NEC is associated with changes in the expression of a number of acute phase proteins and cytokines, such as C-reactive protein (CRP), procalcitonin (PCT), calprotectin (CP). To determine their diagnostic and prognostic significance there were performed studies of the dynamics of the blood levels of CRP, PCT and CP in preterm infants with NEC. A total of 68 premature infants with conservative and surgical stages of the NEC were examined. In all patients at admission, 3rd and 7th day of the treatment there was determined the serum concentration of CRP, PCT and CP. The gradual significant decline in CRP, PCT and CP. Blood concentrations was established at the 7th day of the observation ofpatients with conservative stage of NEC, which was associated with a favorable outcome of the treatment of NEC in this group of preterm infants. More pronounced changes in these markers in the blood of patients with surgical stage of the SEC due to a sharp increase in concentration and a lack of the decline in their content in the course of treatment, are associated with severe NEC and are a formidable sign of unfavorable course of the NEC, which requires timely revision and optimization of the treatment of such patients.
Ultrasonic evaluation of the hepatic parenchyma in the end-stage cirrhosis in children with rare metabolic diseases
Authors: Dvoryakovskiy Igor V. , Ivleva S. A. , Dvoryakovskaya G. M. , Potapov A. S. , Volynets G. V. , Smirnov I. E.
Published: July 2019

There were examined 209 children, agedfrom 3 months to 18years with metabolic liver diseases (MLD) of various etiology. The diagnosis of MLD was based on data of totality of clinical laboratory indices and data of molecular genetic studies. By means of ultrasonic (US) methods there was performed an evaluation both of the structure of the liver parenchyma and the grade of the pronouncement offibrosis with the use of traditional US method and non-invasive method for the quantitative assessment of the structure of liver parenchyma Acoustic Structure Quantification (ASQ) with the determination of density index (DI). At that US data were compared with morphological observations. According to data of the traditional US examination the signs of liver cirrhosis were of the «streaking» of the hepatic image, cirrhotic nodes and signs of portal hypertension. According to ASQ data in the end-stage cirrhosis DI was in the range of from 2.77 to 4.58 in dependence on etiologic factor: in glycogen storage disease in the average accounted of 2.88, in patients with Wilson disease -3.08, in hereditary tyrosinemia type 1 (HT-1) - 3.37, in cystic fibrosis patients - 3.89 and in congenitalfibrosis - 4.18. Comparative analysis of US and morphological data showed the expediency of complex non-invasive US observations in the assessment of the pronouncement of the stage of liver fibrosis in MLD children.
Reproductive health of adolescents: problems and solutions
Authors: Simakhodskiy Anatoly S. , Ippolitova M. F.
Published: July 2019

Development and preservation of reproductive potential is the actual practical direction of national health care. There are presented results of the medical examination of the child population of St. Petersburg, there are noted gender-age features of somatic, urological and gynecological pathology in adolescents. The effectiveness of medical and social system of the care of adolescent reproductive health was established to manifest by the increased their interest and demand for special consultative structures, the decrease in the number of abortions and sexually transmitted infections. Primary health care activities of youth consultation specialists in conjunction with the teaching teams on moral and sexual education and shaping of healthy lifestyle provide the reduction in the level of risk sexual behavior of adolescents and the improvement of their medical activity. There was shown the necessity of the further improvement of the system of medical and social care for adolescents for the prevention of unwanted pregnancies, sexually transmitted diseases, bad habits and shaping of healthy lifestyle skills.
VITAMIN D AND ALLERGIC DISEASES IN CHILDREN
Authors: Smirnova Galina I. , Rumyantsev R. E.
Published: July 2019

There are presented data on the participation of vitamin D in the formation of various forms of allergic pathology in children. The spectrum of knowledge about the biological properties of vitamin D has recently expanded significantly. There are described peculiarities of metabolism of vitamin D and its participation in the leading links of the pathogenesis of atopic dermatitis (AD): in the regulation of the immune response, violations of the integrity of the epidermal barrier and the realization of allergic inflammation in the skin. The pathogenetic significance of vitamin D deficiency in the formation of bronchial asthma (BA) is discussed. Possibilities of the use of vitamin D and its analogues in AD and BA patients are indicated. The authors believe the compensation for vitamin D (hormone) D deficiency in allergic pathology to be an important preventive and curative task within the framework of therapeutic strategies aimed at improving the quality of life of sick children.
IMMUNIZATION OF BRONCHOPULMONARY DYSPLASIA PATIENTS AGAINST RESPIRATORY PATHOGENS
Authors: Davydova Irina V. , Namazova-Baranova L. S. , Fedoseenko M. V. , Kazakova K. A. , Tkachenko N. E. , Akoev Yu. S.
Published: July 2019

Prevention of exacerbations of bronchopulmonary dysplasia (BPD) directly affects the outcome of the disease and belongs to the priority areas of pulmonology of early childhood age. Seasonal immunoprophylaxis of the severe course of respiratory syncytial viral infection (RSVI) with palivizumab and vaccine prophylaxis of pneumococcal and hemophilic infections in children who have formed BPD has been established to allow to reduce the frequency of hospitalization, resuscitation and death. The authors present their own data on results of passive and active immunization of BPD children against pathogens of the respiratory spectrum.
NEW APPROACHES TO HELPING CHILDREN AT THE CHILDREN’S CITY ADVISORY-DIAGNOSTIC CENTER
Authors: Zdanova L. A. , Salova Marina N. , Knyazeva I. V. , Kochetova A. V. , Laykova T. L.
Published: July 2019

There are presented data of a comprehensive study of the health status of schoolchildren, there is given the characteristics of their physical and neuropsychic development, as well as the morbidity rate of children, with taking into account sequellae of perinatal lesions of the central nervous system. In children with chronic somatic pathology, neurological disorders and disorders of the psychoemotional sphere were established to be often detected. This determines the need for a comprehensive neuro- and psychosomatic approach to their treatment and rehabilitation. One of the forms of personification of medical and social assistance for such children was shown to be a modular approach allowing form complex programs consisted of these modules for correction of various health disorders. The use of these modules has prospects, as it optimizes the activity of consulting and diagnostic centers.
Hidrovia do Rio Madeira como indutor de desenvolvimento microrregional das comunidades tradicionais do Baixo Madeira em Porto Velho
Authors: Lopes Iasmin de Magalhães Oliveira , Magalhães Marcos Thadeu Queiroz
Published: July 2019

De acordo com órgãos responsáveis pelas hidrovias e transportes de cargas, atualmente a hidrovia do Rio Madeira, é a segunda via mais importante para o transporte de cargas e escoamento de produtos na Amazônia, ficando atrás somente do rio Amazonas. Além dessa função comercial, por ela trafegam também moradores de comunidades tradicionais pertencentes ao Município de Porto Velho que desenvolvem uma relação de sustentabilidade para com o rio. O presente artigo tem o objetivo de levantar aspectos empíricos relacionados ao uso do transporte hidroviário na região. Para levantamento de dados das comunidades foram feitas entrevistas e aplicação de questionários com moradores das comunidades tradicionais dos distritos de São Carlos, Nazaré, Calama e Demarcação, visitas em órgãos competentes ao tema e consulta a bibliografias específicas. Espera-se na conclusão deste trabalho, ter subsídios técnicos para auxiliar no planejamento da mobilidade das comunidades em questão, facilitando o acesso a serviços básicos e ampliar o campo de estudo sobre a temática.
As intervenções contemporâneas em bens culturais patrimonializados. O caso de Portugal.
Authors: Schlee Andrey de Aspiazu , Medeiros Ana Elisabete De Almeida
Published: July 2019

O artigo instiga o leitor a refletir sobre intervenções contemporâneas em bens culturais patrimonializados. Se no Brasil pode ser constatada certa dificuldade na aceitação dessas intervenções, em outros lugares é possível encontrar exemplos a serem considerados. No cenário internacional, Portugal se revela um objeto de estudo em potencial. De que maneira os portugueses têm alcançado qualidade reconhecida em suas intervenções contemporâneas em bens culturais patrimonializados? As intervenções têm contribuído com a sustentabilidade de tais bens? Para responder a essas questões, o artigo se divide em introdução, conceitos de cultura e patrimônio, referencial teórico, estudos de caso e conclusões. No referencial teórico exploramos os termos “cultura” e “patrimônio”, bem como recuperamos a “Teoria do valor dos monumentos” de Alois Riegl. Tais conceitos e teoria serão retrabalhados e contextualizados em três estudos de caso, todos localizados na cidade do Porto, Portugal. O primeiro, considera a escala urbana, e analisa a intervenção ocorrida na Ribeira, junto às margens do Rio Douro. O segundo, trabalha entre o urbano e o edificado, estudando a Praça Lisboa, localizada no entorno imediato da Igreja dos Clérigos. Por fim, o terceiro estudo de caso explora o novo edifício da fundação Serralves, uma intervenção afastada da cidade, mas junto a jardim e residência-museu. Por fim, as conclusões apontam para o fato de que os portugueses têm alcançado grande qualidade em suas intervenções contemporâneas, sempre agregando novos valores aos espaços ou edifícios já patrimonializados, o porto, a igreja, a fundação.