bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of the type of anesthesia on early movement after hip and knee joint replacement operations: A comparative study between general and spinal anesthesia
Authors: alatmah Mohammad amin alsaleh , kayed Fadi mohammed , Raqamani Najwa
Published: July 2024

Introduction
The type of anesthesia affects postoperative patient outcomes (morbidity and mortality, length of hospital stay), as spinal anesthesia is associated with a shorter length of stay in the hospital and fewer complications compared to general anesthesia. Early movement after joint surgery is essential for optimal rehabilitation and to reduce Complications. Our study aimed to determine the effect of the type of anesthesia on early movement after hip and knee replacement operations.
Methods
Cross-sectional study, conducted in Damascus Hospital (Al-Mujtahid) from 4/4/2024 to 6/10/2024. Patients were studied in the Department of Orthopedic Surgery, and the number of patients studied was 100 patients (undergoing general and spinal anesthesia).
Results
Out of 100 patients, the percentage of males was (63%) compared to females (37%). Their ages ranged from 30–89 years, with an average age of 73.41 years. Type of anesthesia was spinal anesthesia (51%) versus general anesthesia (49%). Type of surgery, “hip arthroplasty” (62%) versus “knee arthroplasty” (38%). The time for return to movement was as follows: “after 6 weeks” (44%), “after a day” (38%), “after a week” (18%).
Conclusion
We found that operations performed under spinal anesthesia have more positive effects compared to general anesthesia, in terms of the intensity of pain immediately after surgery, patients not suffering from annoying symptoms, and an early return to movement.
Suppressed Blinking and Pure Single-Photon Emission in Near-Infrared InAs Colloidal Quantum Dots with Strong Exciton Confinement
Authors: Yang Yi , Li Jialu , Zhai Jingwen , Li Binghan , Zhang Jiancheng , Chen Zhihao , Xiao Liantuan , Lai Runchen , Zeng Zaiping , Zhang Guofeng , Ji Botao
Published: July 2024

Colloidal quantum dots (QDs) have emerged as potential single-photon emitters for quantum information processing due to their high color tunability and scalable production. However, strong Auger non-radiative recombination, while enabling photon antibunching in single QDs, also causes fluorescence blinking when QDs become charged. This poses a significant challenge in achieving both blinking-free emission and high-purity single-photon emission. Here, we address this issue with highly bright near-infrared (NIR) emitting InAs/InP/ZnSe/ZnS QDs, where the ZnSe layer acts as a confining layer to create a straddling band alignment. Single-QD measurements reveal that QDs with a thin ZnSe shell exhibit frequent Auger-related blinking. In contrast, increasing the thickness of the ZnSe shell reduces photo-charging by isolating excitons from the surface, significantly suppressing blinking. Importantly, these thick-shell QDs maintain high single-photon purity, with a g(2)(0) value below 1%. This results from strong exciton confinement in the cores, confirmed by an ultrafast biexciton Auger decay rate. These findings offer a solution to achieve non-blinking characteristics without compromising single-photon purity, highlighting the potential of InAs-based QDs as efficient quantum light sources for telecommunication applications.
ETIOLOGY AND DENTAL STATUS IN PATIENTS WITH DENTITION DEFECTS IN THE RESIDENTS OF THE TRANSCARPATHIA
Authors: Klytinska Oksana , Martyts Yurii , Dunec Roman , Tymchak Vasyl
Published: July 2024

The aim of the study. To evaluate the dental status of patients with dentition defects, residents of the Transcarpathia, and to establish the causes of their occurrence.
Materials and methods. The dental status was determined in 450 middle-aged people, residents of the Transcarpathia. The etiology of dentition defects was established, and an index assessment of hygiene, inflammatory and destructive changes in the periodontium, resorption of alveolar processes, and bone type was performed. The mathematical analysis and verification of the results, as well as the calculation of the arithmetic mean and standard errors were performed using the Statistica 6.0 software.
Results and discussion. In the case of bounded edentulous spaces of 1–2 adjacent teeth, complicated caries prevailed in the etiology in 57.0 %; in the case of bounded edentulous spaces of 3 or more adjacent teeth, periodontal tissue diseases prevailed in 58.0 % (25.8 % – 16 in the upper jaw, 32.2 % – 20 in the lower jaw). In free-end edentulous spaces, periodontal tissue diseases prevailed among the etiologic factors: unilateral – in 75.0 %, bilateral – in 79.4 %. The hygiene was not satisfactory, the presence of moderate and severe gingivitis and periodontitis was observed with the prevalence of D2 bone type in 53.3 % of patients with bounded edentulous spaces, and 54.5 % of patients with free-end edentulous spaces.
Conclusions. In the middle-aged adult population of the Transcarpathia, bounded edentulous spaces account for 26.6 %, and free-end edentulous spaces account for 73.4 %.
INDEX ASSESSMENT OF THE CONDITION OF PERIODONTAL TISSUES IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE
Authors: Hasiuk Petro , Bezushko Alina , Vorobets Anna , Dzetsiukh Tetiana
Published: July 2024

Introduction. Significant prevalence of periodontal diseases, tendency to progress with the subsequent loss of teeth, onset at a young age, decrease in the quality of life of patients and significant financial costs determine the relevance of this medical and social problem. The problem of gastroesophageal reflux disease (GERD) is being increasingly paid attention by researchers and doctors due to the high prevalence and variety of its clinical manifestations. One of the atypical (extraordinary) syndromes of gastroesophageal reflux disease is dental. The purpose of the research was to assess the condition of periodontal tissues in patients with gastroesophageal reflux disease.
Materials and methods. For the study, 65 patients with GERD were selected who had been hospitalized to the gastroenterology department of Ternopil City Hospital No. 2. In total, the sample included 34 (52.31 %) men and 31 (47.69 %) women. To identify inflammatory changes in the gum mucosa, the papillary-marginal-alveolar index (PMA) and the complex periodontal index (CPI) according to P.O. Leus (1989) were used. Statistical processing of the data obtained during the study was carried out using the licensed Microsoft Excel 2016 and Statsoft Statistica 12 statistical analysis packages.
Results. As a result of our study, we found that only 18.5 % of patients suffering from GERD had clinically healthy gums. 9.2 % of patients showed signs of mild gingivitis (PMA index values were within 20 %). According to the RMA index, 33.8 % of patients in the main group were diagnosed with moderate gingivitis (values ranged from 25–50 %). In 38.5 %, manifestations of severe gingivitis were visualized (the PMA index value was more than 51 %). We have found that in patients with GERD, the manifestations of inflammatory phenomena in periodontal tissues increase with age and their severity increases. According to the data obtained when determining the CPI index, 11.2 % of patients with erosive lesions of the esophagus were diagnosed with moderate periodontal tissue damage (CPI value was (2.9 ± 0.1)). In 44.4 % of patients with the erosive form of GERD, mild periodontal tissue damage was visualized (CPI = (1.6 ± 0.1)). All patients with periodontitis secondary to erosive GERD were elderly (45–59 years, according to WHO). Only 44.4 % of patients with the erosive form of GERD and 100.0 % of patients with non-erosive GERD had no inflammation of periodontal tissue (the average CPI value did not exceed 1.0).
Conclusions. Based on the studies described above, we can come to the conclusion that inflammatory processes in the tissues of the periodontal complex and oral mucosa in patients suffering from gastroesophageal reflux disease are interconnected processes that aggravate each other.
UNIVERSAL CLASSIFICATION OF SOMATOTYPES BASED ON BIOIMPEDANCE ANALYSIS OF BODY COMPOSITION
Authors: Feketa Volodymyr , Palamarchuk Olha , Rishko Oleksandr , Nemesh Marianna , Krichfalushii Oksana , Patskun Sylviia
Published: July 2024

Introduction. In connection with the progressive spread of obesity in most countries of the world, early identification of overweight individuals and prevention of related metabolic disorders remains an urgent problem. Traditional body mass index (BMI) has limited specificity, making it difficult to identify risks.
The goal of our work is to create a universal classification of somatotypes based on bioimpedance survey data, which will take into account the component composition of the body and its role in the pathogenesis of obesity.
Methods: The study included 192 children aged 9 to 14 years. The "TANITA MC-780 MA" bioelectric impedance analyzer was used to measure indicators of body composition, with the help of which body weight, body mass index, total fat content, and absolute limb muscle mass were estimated. In addition, in order to determine the type of fat distribution in the body, the ratio of waist circumference to hip circumference was determined.
Results: Analysis of body composition indicators and waist-to-hip ratio (WHR) in three groups of girls and boys, formed according to body mass classification by BMI, showed that most indicators of body composition and WHR did not differ statistically significantly between groups. The exception was the indicator of total fat content (TF), which distinguished the group of children with obesity from others. Despite this, other parameters, in particular MML%, did not show statistically significant differences between groups. In connection with the heterogeneity of the studied samples and the limitations of BMI as an indicator of obesity, we have proposed a new approach to the classification of somatotype, which is based on the ratio of the content of skeletal muscles, total fat and its distribution in different regions of the body. This classification, which is denoted by the abbreviation MFD (Muscles, Fat, Distribution), uses three key parameters and divides patients into 27 combinations according to the gradations of BMI%, TF% and WHR. This approach makes it possible to increase the accuracy of the classification of risk groups in relation to overweight and obesity.
Mapping the Locations of Medical Specialists in the Ministry of Health’s Hospitals in Malaysia by Specialty, Subspecialty and Area of Interest
Authors: Ismail Hirman ,   Medical Development Division, Ministry of Health Malaysia, Putrajaya, Malaysia, Abdullah Mohamed Hirman , Osman Sabrizan , Che Arshad Faarhana , Jalaluddin Siti Norsyazwanis , Osman Nur Fadzilah , Kamarulzaman Nor Akmal Hakim , Abd Kadir Badiuzzaman ,   Medical Development Division, Ministry of Health Malaysia, Putrajaya, Malaysia,   Medical Development Division, Ministry of Health Malaysia, Putrajaya, Malaysia,   Medical Development Division, Ministry of Health Malaysia, Putrajaya, Malaysia,   Medical Development Division, Ministry of Health Malaysia, Putrajaya, Malaysia,   Medical Development Division, Ministry of Health Malaysia, Putrajaya, Malaysia,   Medical Development Division, Ministry of Health Malaysia, Putrajaya, Malaysia,   Medical Development Division, Ministry of Health Malaysia, Putrajaya, Malaysia
Published: July 2024

Mapping the distribution of medical specialists in the Ministry of Health (MOH) Malaysia facilities is expected to be more complex as the demand for specialty and subspecialty services increases in the future. A more robust and definitive gap analysis is needed to facilitate planning and resource allocation. The Medical Development Division developed a master list of framework of specialties, subspecialties and areas of interest, and Specialist Database Module in the Medical Programme Information System (MPIS) as tools to facilitate mapping of services. Relational database of specialists’ location, facilities, workload, population profile and other relevant parameters were developed to provide data visualisation in specific dashboard. Needs versus supply ratio is proposed as one of parameters to visualise specialised medical services distribution by geographical localities.
Risk Factors Associated with Cutaneous Reactions Following COVID-19 Vaccine Immunisation: A Registry-Based Case-Control Study
Authors: Hwei Lin Teh ,   Pharmacy Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia, Keowmani Thamron , Min Moon Tang ,   Pharmacy Department, Hospital Wanita dan Kanak-Kanak, Sabah, Malaysia,   Department of Dermatology, Sarawak General Hospital, Sarawak, Malaysia
Published: July 2024

Background: In Malaysia, following extensive COVID-19 vaccination, Hospital Kuala Lumpur reported an increase in cutaneous reactions post-immunisation. To understand this, a case-control study was initiated to identify potential risk factors. Methods: This registry-based, unmatched case-control study encompasses all adverse event following immunisation (AEFI) reports associated with COVID-19 vaccines, received by the Department of Pharmacy at Hospital Kuala Lumpur through the Malaysian Adverse Drug Reactions Advisory Committee (MADRAC) AEFI reporting forms. Twenty-four potential risk factors were evaluated, including demographic information, medical history, food allergies, COVID-19 vaccination history and prior SARS-CoV-2 infection, were evaluated using MADRAC AEFI reporting forms. Odds ratio (OR) with 95% confidence interval (CI) were estimated using univariable and multivariable logistic regression. Results: Cutaneous reactions were more frequent in middle-aged females, especially after the first COVID-19 vaccine dose. These reactions, primarily mild and generalised, included pruritus and urticaria. Notably, 52% were delayed reactions (more than 4 h post-vaccination). Factors associated with increased risk of cutaneous reaction following COVID-19 immunisation included history of seafood and shellfish allergy (adjusted odds ratio [adjOR]: 2.11; 95% CI: 1.12, 3.96; P = 0.020), history of vaccine allergy (adjOR: 4.07; 95% CI: 1.44, 11.54; P = 0.008) , past dermatological diseases (adjOR: 5.48; 95% CI: 2.03, 14.78; P = 0.001), and past medication allergy (adjOR: 2.12; 95% CI: 1.36, 3.31; P = 0.001). Conclusion: Self-reported histories of allergies to vaccines, foods or medications were found to increase the likelihood of cutaneous reactions following COVID-19 vaccination. These reactions, which were predominantly mild, did not hinder the administration of the second vaccine dose. The majority of reactions occurred after the first dose, manifesting as generalised pruritus and urticaria. They were effectively managed with oral antihistamines and low-dose corticosteroids, thereby avoiding the need for hospitalisation.
First 100 Reported Cases of Supine Percutaneous Nephrolithotomy in Malaysia: An Alternative Effective and Safe Approach to Treat Renal Stones
Authors: Han Kun Ng ,   Department of Urology, Sarawak Heart Centre, Sarawak, Malaysia, Chee Hoong Loo , Meng Shi Lim ,   Department of Urology, Sarawak Heart Centre, Sarawak, Malaysia,   Department of Urology, Sarawak Heart Centre, Sarawak, Malaysia
Published: July 2024

Background: Supine percutaneous nephrolithotomy (s-PCNL) offers great benefits from urological and anaesthetic points of view. We present the first evaluation of the outcomes of s-PCNL in Malaysia. Our aim was to explore the safety and efficacy of s-PCNL. Methods: Institutional review board approval was obtained from the National Medical Research Register (NMRR ID-21002225-WLP). We retrospectively reviewed 115 patients with renal pelvis stones who underwent single renal access during s-PCNL between November 2020 and May 2023. Patients who underwent simultaneous ipsilateral or contralateral endourological procedures were included. The data were analysed to determine stone-free rates (SFR), major complication rates, blood transfusion rates, operative times and lengths of hospital stay (LOS). Results: The SFR was higher for the single middle calyceal renal access (MCA) group than for the lower calyceal renal access (LCA) or upper calyceal renal access (UCA) groups (OR: 1.76; 95% confidence interval [CI]: 0.63, 4.92). In total, 0, 1 and 2 patients had major complications in the UCA, MCA and LCA groups, respectively (P = 0.453). One of the 115 patients (0.9%) needed blood transfusion. Subgroup analysis revealed mean operative times of 76.3 min and 78.6 min for patients who underwent sole s-PCNL (PCNL-only group) and those who had simultaneous ipsilateral and contralateral endourological procedures (PCNL-plus group), respectively (P = 0.786). The overall mean LOS was 2.9 days. Conclusion: s-PCNL is a safe and effective alternative treatment for renal stones. We would recommend s-PCNL for patients who require an ipsilateral/contralateral endourological procedure (URS/RIRS) because it is time-efficient. All renal accesses are safe. Single MCA is recommended for complete stone clearance.
Прогностическое значение цитотоксических CD8-позитивных Т-лимфоцитов реактивного микроокружения опухоли при диффузной В-крупноклеточной лимфоме
Authors: Ванеева Елена Викторовна , Росин В. А. , Дьяконов Д. А. , Глубоковских Н. В.
Published: July 2024

AIM. To assess the prognostic value of cytotoxic CD8-positive Т-lymphocytes of the reactive tumor microenvironment in diffuse large B-cell lymphoma (DLBCL).
MATERIALS & METHODS. The study enrolled 124 patients with newly diagnosed DLBCL. All patients received the standard R-CHOP first-line immunochemotherapy. Immunochemistry and morphometry were used to assess the relative count of CD8-positive Т-lymphocytes in the biopsy samples of lymph nodes or other tumor tissues. In each biopsy sample, 20 fields of view were analyzed to assess the mean relative count of CD8-positive Т-lymphocytes in the reactive tumor microenvironment. Т-cells were counted by double-blind technique. Patients were aged 23–80 years (median 59 years); there were 62 women and 62 men.
RESULTS. Obtained by ROC-analysis, the threshold value of the CD8-positive Т-lymphocyte count in the reactive tumor microenvironment was 13 %. The subthreshold relative count of cytotoxic CD8-positive Т-lymphocytes (≤ 13 %) was associated with extranodal lesions in DLBCL patients as well as with the lack of complete response to the R-CHOP first-line therapy and worse progression-free (PFS) and overall survival (OS) rates. In the group with the above-threshold (> 13 %) count of CD8-positive Т-lymphocyte, the 5-year PFS was 60 % (median not reached), in the group with the subthreshold count it was 45.3 % (median 39 months; p = 0.036); the 5-year OS was 78.3 % (median not reached) and 45.3 % (median 40 months) in the groups with the above- and subthreshold CD8+ T-cell counts, respectively (p = 0.001).
CONCLUSION. The results of the present study clearly indicate the need to assess the count of cytotoxic CD8-positive Т-lymphocytes of the reactive tumor microenvironment in DLBCL patients as early as on diagnosis verification. It is likely that this approach will allow clinicians to more accurately predict the course of DLBCL.
Sound Fragments: From Field Recording to African Electronic Stories
Authors: De Vries Lee-Ann
Published: July 2024

Review of: Sound Fragments: From Field Recording to African Electronic Stories. Noel Lobley, 2022. Middletown, Connecticut: Wesleyan University Press. 16 illustrations, bibliography, index. 348 pages. ISBN: 978-0-8195-8077-1
Source credibility of beauty vloggers and consumer purchases of vegan cosmetics: The mediating role of cognitive and affective attitude
Authors: Ngoc Le Bao , Tien Vu Viet , Thi Le Mai
Published: July 2024

Vegan cosmetics have become more popular among consumers due to increased environmental awareness and health consciousness after the COVID-19 pandemic. This study aims to investigate the influence of beauty vloggers’ credibility on consumers’ purchase intention toward vegan cosmetics. An integrated research model was built based on the source credibility and stimulus-organism-response theory. Data were collected from a questionnaire survey with 382 Vietnamese consumers at the minimum age of 18 who had experience watching beauty vloggers reviewing vegan cosmetics on YouTube. Partial least squares structural equation modeling was applied to analyze the collected data. The results show that the beauty vloggers’ expertise, trustworthiness, and physical attractiveness all positively impact cognitive and affective attitudes, influencing consumers’ purchase intention. Furthermore, these factors positively impact consumers’ intention to purchase vegan cosmetics. Therefore, cognitive and affective attitudes partially mediate the relationship between the beauty vloggers’ credibility and consumers’ purchase intentions. Given that the direct and indirect effects point in the same direction, these mediators are classified as complementary. This study contributes to deeper understanding of consumers’ intention to purchase vegan cosmetics recommended by beauty vloggers.
Acknowledgment The authors would like to thank the Posts and Telecommunications Institute of Technology (PTIT) and the International School, Vietnam National University (VNU), Hanoi, Vietnam, for providing research assistance.
IDENTIFICATION OF QUINOLONE-TRAIZOLE HYBRIDS AS POTENTIAL INHIBITORS USING IN SILICO APPROACH
Authors: Ejaz Syeda , Alsfouk Aisha , Shamim Tahira , Sumreen Laila , Mahmood Hafiz , Li Chen
Published: July 2024

Alzheimer’s disease (AD) is a most common form of dementia and results in memory loss, disorientation, impaired thinking and changes in personality as well as mood. The dementia cases mostly turn into the Alzheimer’s disease (AD). Another disease, the Parkinson’s disease (PD), mainly affects dopaminergic neurons in substantia nigra. A series of previously synthesized quinolone-triazole hybrids were investigated and evaluated for their anti-acetyl cholinesterase and against monoamine oxidase reactive properties through in silico characterization. The ground state electronic properties were determined by electron density of the compounds through DFTs (density functional theory) calculation. The geometries of all compounds were optimized using Becke-3-parameter-Lee-Yang-Parr (B3LYP) method and 6-311g basis set. Docking studies were conducted using the AutoDock and Molecular Operating Environment (MOE) software and the results of the potent derivatives found to be encouraging. The data confirmed that all the compounds have drug-like properties and was further confirmed by ADMET (absorption, distribution, metabolism, excretion and toxicity) properties.
CEO’s tendency to narcissism and optimism: The impact on a company’s debt burden before and during the COVID-19 pandemic
Authors: Fedorova Elena A. ,   Financial University under the Government of the Russian Federation, Krotov Dmitry P. , Anosova Anastasia O. ,   Financial University under the Government of the Russian Federation,   Financial University under the Government of the Russian Federation
Published: July 2024

Goal: to assess the impact of the level of the CEO’s optimism and narcissism on the capital structure of companies in the developed and emerging markets before and during the COVID-19 pandemic. Metodology: the study is based on 100 Western companies from the “Forbes Global 2000” list and 50 leading Russian companies in terms of revenue and capitalization. The assessment of narcissism and optimism was carried out by application of text analysis based on the bag of words and the pronoun counting method. Using the Anglin dictionary, four manifestations of narcissism were assessed — superiority (manifestation of superiority), vanity (vanity), exhibitionism (narcissism), self-sufficiency (arrogance). The hypotheses about the relationship between a CEO’s personality characteristics (narcissism and optimism) and the company’s capital structure were tested by using panel regression with fixed effects. Findings: the study revealed that the influence of the behavioral characteristics of a CEO increased during the crisis period (pandemic), which may indicate the tendency of managers to act less rationally and more impulsively; the result was confirmed for both domestic and foreign managers. The interplay between narcissism and optimism has a similar trend with the level of debt burden in Russian and international companies, i.e. for decision-making, the personal characteristics of management are more important than regional business specifics. Originality and contribution of the authors: the study contributes to the literature on behavioral finance by assessing the impact of a CEO’s narcissism and optimism in the context of the COVID-19 pandemic and expanding the existing work towards the analysis of crisis situations as well as behavioral finance in different economic and sociocultural areas. The paper proposes text analysis to assess personal characteristics of CEOs.
Knowledge management practices in Russian educational institutions
Authors: Pleshkova Anastasia Yu. ,   HSE University
Published: July 2024

Goal: the aim of this study is to analyze the practices of knowledge management in Russian educational institutions and compare the obtained results with foreign practices. Metodology: the systematic analysis of literature and the quantitative survey of respondents of Russian educational institutions were carried out. The content of 57 scientific articles was analyzed; 74 unique knowledge management practices were identified and grouped for the survey. Based on the responses of 120 heads of administrative divisions of educational organizations, redistribution of the identified practices was carried out in the key areas of application, thereby forming a different set of practices from foreign countries. Findings: the analysis and systematization of secondary sources of information revealed a set of knowledge management practices in Russian educational institutions that differ from the foreign practices. The descriptive research and literature review identified the mostly used knowledge management practices in Russia. Originality and contribution of the authors: the work contributes to the field of knowledge management by proposing the differences between foreign and Russian knowledge management practices, as well as supplementing and modifying the existing set of practices in the context of educational organizations.
REFLEXÕES NO CAMPO DA CIÊNCIA DA INFORMAÇÃO SOBRE A CONSTRUÇÃO DA MEMÓRIA SOCIAL NAS REDES DIGITAIS
Authors: Silva Campos Erica , Marques Gerlin Meri Nadia , Farias de Moraes Margarete , Da Silva Luiz Carlos
Published: July 2024

Researchers in the field of Information Science have made efforts to understand the processes of construction of social memory in the context of social networks, resulting in research with multiple perspectives and  differentiated areas, which have great scientific and social relevance. Having said that, the objective was to analyze the frequency of the approach to the concept of social memory in digital networks and the issues related to this theme that are of interest to researchers in this science. This is an exploratory research of a qualitative and quantitative nature, using the content analysis technique as inspiration for the composition of the methodology, and, thus, for the creation of analysis categories so that it was possible to identify variations in terms used for the concepts “patrimony” and “memory”, and also making it possible to understand how these concepts have been debated by Information Science researchers. Studies were found that address different variations of the concepts of memory and patrimony in contemporary times and reflect on the informational phenomena that permeate the construction of social memory in digital media. The availability of information through the sharing of digital collections from libraries, museums, personal, public and institutional archives are constituents of digital heritage and emerge as channels for maintaining social memory and building knowledge. Faced with this, it explains the need to preserve digital heritage and improve content description mechanisms, implement metadata standards in the processes of describing and retrieving information in digital media. It also addresses the survey of ethical issues such as the social responsibility of citizens in the production and sharing of information on the web, much of which still needs to be discussed.
 
Keywords: memory; social memory; patrimony;  social networks.
CDK1 Acts as a Prognostic Biomarker Associated with Immune Infiltration in Pan-Cancer, Especially in Gastrointestinal Tumors
Authors: Shen Jiemiao , Gong Xing , Tan Siyue , Zhang Yuxin , Xia Rong , Xu Shuyu , Wang Shaozhuo , Zhou Haojie , Jiang Yinyue , Zhao Tie , Zhang Yi , Tang Hua , Wang Chao
Published: July 2024

Objective:

Cyclin-dependent kinase 1 (CDK1) regulates the cell cycle and is highly expressed
in most tumors. CDK1 expression has been associated with poor disease prognosis. This
study aimed to identify the prognostic value of CDK1 in pan-cancer and investigate the association
between CDK1 expression and immune cell infiltration.

Methods:

CDK1 expression and its correlation with prognosis in pan-cancer were analyzed using
online databases. Immune infiltration was assessed by ESTIMATE and CIBERSORT algorithms.
We then evaluated the relationship between CDK1 expression and tumor mutational burden
(TMB), microsatellite instability (MSI), or tumor-infiltrating immune cells. In addition, we
performed the co-expression analysis of immune-related genes and GO analysis with CDK1 expression
in pan-cancer. Finally, we compared the CDK1 expression profile with the immune-related
genes in 30 pairs of clinical gastrointestinal tumor samples.

Results:

Our analysis demonstrated overexpression of CDK1 in most tumor tissues, especially in
gastrointestinal tumors. The high expression of CDK1 was associated with poor overall survival,
disease-specific survival, disease-free interval, and progression-free interval in kidney renal papillary
cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD),
pancreatic adenocarcinoma (PAAD), prostate adenocarcinoma (PRAD), and sarcoma (SARC).
Besides, CDK1 expression was significantly associated with TMB in 22 cancer types and
MSI in 8 cancer types as well as greater frequencies of MSI-high (MSI-H) status and high tumor
mutational burden (TMB-H) in uterine corpus endometrial carcinoma (UCEC), stomach adenocarcinoma
(STAD), sarcoma (SARC), rectum adenocarcinoma (READ), mesothelioma (MESO),
head and neck squamous cell carcinoma (HNSC), and colon adenocarcinoma (COAD). In addition,
CDK1 expression correlated with immune cell infiltrating levels, such as M0, M1, or M2
macrophages, memory CD4 T cells, T follicular helper cells, and naive B cells. Our data showed
that CDK1 was remarkably correlated with 47 immune-related and immune checkpoint genes in
many cancer types. Furthermore, CDK1 was up-regulated in gastrointestinal tumor samples, especially
in gastric cancer and intestinal cancer. CDK1 was positively correlated with IDO1 in gastric
cancer and PD-1 in intestinal cancer.

Conclusion:

Taken together, our data demonstrated the roles of CDK1 in oncogenesis and metastasis
in pan-cancer. Thus, CDK1 is a potential prognostic biomarker and a target for tumor immunotherapy.
Review of the Different Outcomes Produced by Genetic Knock Out of the Long Non-coding microRNA-host-gene MIR22HG versus Pharmacologic Antagonism of its Intragenic microRNA product miR-22-3p
Authors: Thibonnier Marc , Ghosh Sujoy
Published: July 2024

Background:

Publications reveal different outcomes achieved by genetically knocking
out a long non-coding microRNA-host-gene (lncMIRHG) versus the administration of pharmacologic
antagomirs specifically targeting the guide strand of such intragenic microRNA. This
suggests that lncMIRHGs may perform diverse functions unrelated to their role as intragenic
miRNA precursors.

Objective:

This review synthesizes in silico, in vitro, and in vivo findings from our lab and others
to compare the effects of knocking out the long non-coding RNA MIR22HG, which hosts miR-
22, versus administering pharmacological antagomirs targeting miR-22-3p.

Methods:

In silico analyses at the gene, pathway, and network levels reveal both distinct and
overlapping targets of hsa-miR-22-3p and its host gene, MIR22HG. While pharmacological antagomirs
targeting miR-22-3p consistently improve various metabolic parameters in cell culture
and animal models across multiple studies, genetic knockout of MIR22HG yields inconsistent
results among different research groups.

Results:

Additionally, MIR22HG functions as a circulating endogenous RNA (ceRNA) or
"sponge" that simultaneously modulates multiple miRNA-mRNA interactions by competing for
binding to several miRNAs.

Conclusions:

From a therapeutic viewpoint, genetic inactivation of a lncMIRHG and pharmacologic
antagonism of the guide strand of its related intragenic miRNA produce different results.
This should be expected as lncMIRHGs play dual roles, both as lncRNA and as a source for
primary miRNA transcripts.
Semiotic Analysis of Curative Preservation in the Jaran Kepang Art Tradition of Temanggung, Central Java
Authors: Nur 'Aini Iftitah ,   Universitas Brawijaya, Rahadatul ‘Aisy Kamiliya , Aulia Citra Nur Sakinah Karina , Surya Ningtyas Rosa , Yuni Pratiwi Kurniasih
Published: July 2024

Art is a skill in creating a quality of work. Indonesia itself is famous for its many arts from Sabang to Merauke. The number of arts that exist around the community makes every region in Indonesia have dances, paintings, or carvings typical of their respective regions, especially in the Java Island area there is the art of Kuda Lumping. Kuda Lumping art performance commonly called Jaran Kepang is one of the original Indonesian traditional arts originating from Temanggung Regency, Central Java. This art is a featured art in Temanggung which is marked by the Jaran Kepang statue located in the eastern district park. Along with its development, the Jaran Kepang Temanggung dance no longer features stories about Diponegoro soldiers that characterize this dance. Some cultural initiators in Temanggung have modified the dance to include elements of Balinese art. Therefore, preservation is a fitting way to preserve and maintain an object or thing that does require protection, care, or preservation in the hope that the information remains. This research aims to preserve the performing arts of Jaran Kepang Temanggung with curative preservation through visual media, namely photography. This research uses a qualitative descriptive approach method that aims to describe fully and deeply about various phenomena studied and the use of semiotic analysis techniques. The results of this research will be in the form of a photo presentation of the visual preservation of jaran kepang which is useful to facilitate the delivery of messages from the photo of jaran kepang itself. Although this cultural heritage has begun to compete fiercely with the influx of foreign cultures and arts, this dance still shows high appeal and becomes a performance that captivates the hearts of its audience. In this case, the protection and preservation of the art of jaran kepang is needed so that it will always be recognized by future generations.
Efektivitas dan keamanan terapi dengan rejimen yang mengandung linezolid dalam pengobatan multidrug-resistant tuberculosis (MDR-TB): Kajian Sistematik
Authors: Sari Gusti Ayu Putu Laksmi Puspa ,   Program Studi Magister Farmasi Fakultas Farmasi Universitas Surabaya, Surabaya, Indonesia, Herawati Fauna ,   Departemen Farmasi Klinis dan Komunitas, Fakultas Farmasi, Universitas Surabaya
Published: July 2024

Objective: To systematically evaluate the existing evidence regarding the efficacy and safety of therapy with regimens containing linezolid in the treatment of Multidrug‐ resistant tuberculosis (MDR-TB). Data source: The search strategy was undertaken using PubMed, Cochrane, and ScienceDirect databases. Review method: Searching the literature without changing the type of research or year of publication in which articles published until March 14, 2021, are involved in this literature review. The search strategy undertaken using PubMed, Cochrane, and ScienceDirect with the keywords "linezolid", "treatment", "tuberculosis" and "multidrugresistant" which were combined with the use of a Boolean operator "AND". Results: A total of seven studies were included in the final study. Linezolid had efficacy in MDR-TB patients with a much higher level of treatment support in the linezolid therapy group than in the control group (not using linezolid). However, the side effects that occurred were categorized as hematologic, gastrointestinal, neurological, and dermatological which generally occurred after 278 days of use. Severe diarrhea and nausea shortly after starting treatment were felt in 12.5% of patients. The main side effects controlled with linezolid (anemia, thrombocytopenia, and/or polyneuropathy), which generally required discontinuation were reported in 1 study and required discontinuation in 27 (77%) cases. The most important side effect is peripheral neuropathy, necessary to monitor the report by the 5 articles included in the final study. Conclusion: Available evidence has shown linezolid therapy to be effective against MDR-TB treatment. Monitored for the incidence of major adverse neurotoxicity (peripheral or optic neuropathy). To follow side effects and improve clinical outcomes, a combined high dose (1200 mg daily) for the intensive phase followed by a lower dose (300-600 mg daily) for the continuous phase is recommended along with an effective patient to increase the current dose and monitoring.
Flora Farallonensis IV: Gentianales del bosque montano bajo de Pico de Águila en Colombia
Authors: Gamboa-Gaitán Miguel A
Published: July 2024

Este es el cuarto artículo de una serie dedicada a la flora de Los Farallones de Cali. El propósito general de la serie es hacer un inventario de las plantas, algas y hongos estudiando localidades puntuales en Los Farallones. Este artículo está dedicado a las especies del orden Gentianales, familias Asclepiadaceae y Rubiaceae del bosque de Pico de Águila, en el departamento del Valle del Cauca, Colombia. Para hacer este inventario se recolectaron especímenes que fueron secados en el herbario CUVC y enviados a especialistas para su identificación. Se presentan datos sobre la distribución altitudinal y biogeografica de las especies para Colombia por departamentos y algunas ilustraciones para facilitar su identificación. Varias de las especies halladas tienen potencial para estudios de bioprospección.
‘Mala moneda de la plata corriente’. Los intereses mercantiles y la ceca de Cartagena de Indias, 1618-1635
Authors: Amaya Palacios Sebastian
Published: July 2024

Para finales de su reinado, Felipe ii modificó la ley de la moneda como mecanismo económico para mantener los gastos imperiales; sus sucesores Felipe iii y iv recurrieron a la misma medida, pero en una escala aún mayor. Estas decisiones supeditaron la política monetaria a la política fiscal y permitieron a los mercaderes caribeños alinear sus intereses a las necesidades de la Corona. En Cartagena de Indias solicitaron liquidar las monedas de plata baja y fundar una ceca que emitiera moneda fraccionaria para dinamizar sus acuerdos comerciales.
Este artículo busca identificar los intereses de la élite mercantil cartagenera y la primera acuñación de numerario neogranadino. Además, contribuye a sinterizar la efímera existencia de la ceca cartagenera, clausurada por infringir los topes de peso y ley autorizados para sus piezas, dejando a la Casa de la Moneda de Santa Fe de Bogotá como único centro financiero del Nuevo Reino de Granada.
Theological perspectives for post-war Christianity in Ukraine. "Тheology after Bucha"
Authors: Pavlenko Pavlo
Published: July 2024

The town of Bucha became a collective symbol of the modern genocide of Ukrainian people, because it was there where the scale of all the crimes committed against Ukrainians was revealed during the liberation of Kyiv Oblast from the Russian occupiers in March-April 2022. It was Bucha that gave many people in Ukraine the reason to debate if there is God at all. Today, Ukrainian churches began to consider the possibility of "theology after Bucha", asking practically the same questions that Christians and Jews were concerned with after World War II. As then the main question was "Where was God at Auschwitz?" Now the question is where Biblical God was during Bucha genocide, and in a broader context, where God is with the love and mercy in Ukraine after February 24, 2022. The article is nearly the first scientific research of Christianity in Ukrainian academic religious studies during the ongoing Russian-Ukrainian war. The author examines the conditions for the foundation of a new theological system in the realm of Ukrainian Christianity after the victory over rushism, following the example of the theology after the Holocaust/Shoa in Western Christianity after WWII. The article analyses a number of caveats that, if not addressed today, could make the constructive development of the abovementioned theology impossible. The author predicts possible parallels between "theology after Auschwitz" and the future "theology after Bucha". In fact, “theology after Auschwitz" did not radically affect Western, primarily European Christianity after 1945 because it did not provide unambiguous answers to a range of urgent essential questions related to the existence of a believer in the world recovering from the great war. So, with a considerable degree of probability (already evident from the remarks of individual representatives of different religious denominations) there is concern that "theology after Bucha" may fail practically at its beginnings, becoming a "pure theory", having no chances to be applied at the all-Christian level. It is partially clear today that an attempt would be made to launch "theology after Bucha" exactly along the ideological tracks of "theology after Auschwitz", that is, to direct it exclusively to the search for the arguments shifting the burden of responsibility for "Bucha" from God and thereby possibly save Christianity from the ideological crisis it has been in Ukraine after February 24, 2022. The author concludes that if "theology after Bucha" really begins to move along the similar ideological fairway like "theology after Auschwitz", the post-war Christianity in Ukraine will face a disappointing perspective to lose social relevance and, as a result, will be radically reduced to ritualism.
Worldview and religious-cultural orientations of the "Digital Age Human"
Authors: Medzhidova Nargiz
Published: July 2024

This article explores the impact of the digital era on fundamental aspects of human life, including issues of faith, morality, and cultural identity. It highlights that digital technologies have become an integral part of modern human life, making it impossible to ignore their obvious cultural significance today. The focus is on analyzing how contemporary technologies, such as artificial intelligence and the Internet of Things, are reshaping traditional religious practices, facilitating the emergence of new forms of spirituality, and altering traditional religious structures. Both positive and negative consequences of such transformations for individuals and society are discussed. By utilizing digital products and technologies and entering cyberspace, religion strives to make religious heritage, culture, and tradition more understandable and accessible to a larger number of people. The adaptation and transformation of religion can be traced in various directions of activity related to the implementation and mastery of cyberspace and digital space. Examples of the digitalization of religion and religious digital products are provided to substantiate the transformation of religion. The idea is substantiated that studying digital culture today means not so much analyzing its phenomena and artifacts per se, but rather studying the broad transformations occurring with the spread of digital technologies in culture at large.
Features of the social beliefs of the Orthodox Church and Christians of the Evangelical Faith
Authors: Stadnyk Mykola , Kharchenko Vladyslav
Published: July 2024

The article examines the peculiarities of social beliefs of the Orthodox Church and Christians of the Evangelical Faith and their reflection in educational practices. It is shown that the formation of social doctrines is one of the basic tasks of modern Christianity. Social doctrine systematizes and actualizes the role and significance of social beliefs of Christianity, in their essence multi-vector, multi-dimensionality, inte-gration as the main characteristics of the spiritual sphere of the church. Social doc-trines are based on various aspects of theological and ecclesiological beliefs. They can be expressions of the theological tradition’s response to historical problems, social transformations of the digital age, in the confessional discourse, and can also reflect the modern view of a certain church on the issue of the relationship between faith and reason, science and religion, and humanitarian security. Approaches to social beliefs may differ depending on the "confessional color" of a certain religious organization and the information support of this process. According to this study, the implementation of the social doctrines of Christianity is impossible without an analysis of their beliefs aimed at solving both social issues in general and educa-tional ones. The need to develop basic strategies of spiritual education is empha-sized, outline the priorities facing education in a secularized world, but also suggest the development of sustainable concepts in the direction of highlighting the confes-sional worldview regarding the challenges of modern humanitarianism. It is proposed to consider the peculiarities of social beliefs in the system of educational processes of the Orthodox Church and the Christian Church of the Evangelical Faith. The con-clusions emphasize that the social doctrine of the Ecumenical Patriarchate presup-poses a progressive attitude to science and technological progress, encourages the church to use the resources of technological progress and informational resources for preaching. The need for the introduction of an integrated approach in spiritual education, constant informational innovations in the field of training of qualified min-isters who are able to conduct missionary preaching activities taking into account the conditions of the time for an efficient educational process and humanitarian security in the context of transformations of the digital age is being updated.