bluuebunny/crossref_metadata_2025 huggingface dataset:
Modification of Glucose Metabolic Pathway to Enhance Polyhydroxyalkanoate Synthesis in Pseudomonas putida
Authors: Dong Yue , Zhai Keyao , Li Yatao , Lv Zhen , Zhao Mengyao , Gan Tian , Ma Yuchao
Published: November 2024

Medium-chain-length polyhydroxyalkanoates (mcl-PHAs) are semi-crystalline elastomers with a low melting point and high elongation at break, allowing for a wide range of applications in domestic, agricultural, industrial, and mainly medical fields. Utilizing low-cost cellulose hydrolyzed sugar as a carbon source and metabolic engineering to enhance synthesis in Pseudomonas putida is a promising strategy for commercializing mcl-PHAs, but little has been attempted to improve the utilization of glucose for synthesizing mcl-PHAs. In this study, a multi-pathway modification was performed to improve the utilization of substrate glucose and the synthesis capacity of PHAs. To enhance glucose metabolism to flow to acetyl-CoA, which is an important precursor of mcl-PHA, multiple genes in glucose metabolism were inactive (branch pathway and negative regulatory) and overexpressed (positive regulatory) in this study. The two genes, gcd (encoding glucose dehydrogenase) and gltA (encoding citrate synthase), involved in glucose peripheral pathways and TCA cycles were separately and jointly knocked out in Pseudomonas putida QSRZ6 (ΔphaZΔhsdR), and the mcl-PHA synthesis was improved in the mutants; particularly, the mcl-PHA titer of QSRZ603 (ΔgcdΔgltA) was increased by 33.7%. Based on the glucose branch pathway truncation, mcl-PHA synthesis was further improved with hexR-inactivation (encoding a negative regulator in glucose metabolism). Compared with QSRZ603 and QSRZ6, the mcl-PHA titer of QSRZ607 (ΔgcdΔgltAΔhexR) was increased by 62.8% and 117.5%, respectively. The mutant QSRZ609 was constructed by replacing the endogenous promoter of gltB encoding a transcriptional activator of the two-component regulatory system GltR/GltS with the ribosome subunit promoter P33. The final mcl-PHA content and titers of QSRZ609 reached 57.3 wt% and 2.5 g/L, an increase of and 20.9% and 27.3% over that of the parent strain QSRZ605 and an increase of 110.4% and 159.9% higher as compared to QSRZ6, respectively. The fermentation was optimized with a feeding medium in shaker flacks; then, the mcl-PHA contents and titer of QSRZ609 were 59.1 wt% and 6.8 g/L, respectively. The results suggest that the regulation from glucose to acetyl-CoA by polygenic modification is an effective strategy for enhancing mcl-PHA synthesis, and the mutants obtained in this study can be used as chassis to further increase mcl-PHA production.
Rising Strong: Does Personal Resilience Drive Civic Engagement During Disasters?
Authors: Blitstein-Mishor Efrat
Published: November 2024

Background: In the crucible of disasters, civic engagement emerges as a dynamic force that channels individual strength and collective willpower toward the common good. Although it has been recognized as a necessary precondition for community resilience, studies on the motivators for citizens’ activities during disasters are relatively limited. This study underscores the interplay of personal resilience, risk perception, and coping strategies in the context of emergency-oriented civic engagement. It provides a robust framework for comprehending the cognitive and emotional processes that drive individuals’ responses to threats and risks to improve knowledge about public behavior, psychological conditions, and mental health during man-made disasters. Method: an online survey was conducted with a sample of 1514 citizens in Israel. A model incorporating both moderation and mediation effects was proposed. Results: The results reveal a consistent positive relationship between personal resilience and emergency-oriented civic engagement and point to the importance of both the intervening role of risk perception and the moderating role of coping strategies. Conclusions: discuss the importance of resilience-building programs and the promotion of positive coping strategies which can empower individuals to navigate the complexities of risk perception and engage actively in civic activities during disasters.
Characterization of the Physicochemical Properties of Salix psammophila Sand Barriers Degradation Under Ultraviolet Irradiation and Synergistic Water Environment
Authors: Wang Ruidong , Liang Yumei , Meng Zhongju , Gao Yong
Published: November 2024

The degradation of Salix psammophila mechanical sand barriers in desert environments can lead to a reduction in their windbreak and sand-fixing benefits, thereby becoming a significant factor limiting the operational lifespan of these structures. Targeting the typical damage types of S. psammophila sand barriers in the desert, we conducted simulations of desert sunlight and rainfall phenomena and investigated the changing characteristics of the physical, mechanical, and chemical properties of sand barriers in the degradation process. The results clearly indicate that (1) accelerated aging for 288 h represents a critical time point for assessing changes in physical, mechanical, and chemical properties during the interaction between ultraviolet irradiation and water. Following 576 h of accelerated aging, compared with a fresh S. psammophila branch sample (CK), the mass loss percentage was 24.33%, while the basic density decreased by 35.87%, and the modulus of rupture and elasticity decreases by 24.93% and 23.03%, respectively. (2) After accelerated aging for 576 h, the contents of lignin, hemicellulose, and cellulose decreased by 35.93%, 33.84%, and 22.38%, respectively. The interaction between simulated ultraviolet irradiation and water under sunlight intensifies the vigorous physical and chemical reactions occurring within the S. psammophila sand barrier, alters its internal structure, diminishes its mechanical properties, and expedites the degradation of its protective capabilities.
Hagge Configurations and a Projective Generalization of Inversion
Authors: Szilasi Zoltán
Published: November 2024

In this article, we provide elementary proofs of two projective generalizations of Hagge’s theorems. We describe Steiner’s correspondence as a projective generalization of inversion.
Effect of Different Irrigation Programs on Structural Characteristics, Productivity and Water Use Efficiency of Opuntia and Nopalea Forage Cactus Clones
Authors: Araujo Jandis Ferreira Nunes de , Santos João Pedro Alves de Souza , Souza Luciana Sandra Bastos de , Souza Carlos André Alves de , Alves Cléber Pereira , Jardim Alexandre Maniçoba da Rosa Ferraz , Eugênio Danielle da Silva , Souza Leonardo Francelino de , Morais José Edson Florentino de , Santos Wilma Roberta dos , Gois Glayciane Costa , Campos Fleming Sena , Silva Marcos Vinícius da , Montenegro Abelardo Antônio de Assunção , Silva Thieres George Freire da
Published: November 2024

The objective of this study was to evaluate the structural characteristics, yield and water use efficiency of forage cactus under daytime and nighttime irrigation in a Brazilian semiarid region. The experiment followed a completely randomized design in a 3 × 2 factorial scheme, with ten replications: three clones of forage cactus (“IPA Sertânia”—IPA, “Miúda”—MIU, “Orelha de Elefante Mexicana”—OEM) and two irrigation schedules (daytime and nighttime). Irrigation was applied once a week using a graduated cylinder. The structural characteristics (i.e., plant height and width, total number of cladode—TNC; cladode number per emergence order—CN1, CN2 and CN3; cladode area—CA; cladode area index—CAI), productive characteristics (fresh mass production per plant—FM and dry mass—DM) and water use efficiency (WUEFM and WUEDM) were obtained from the plant harvests. Our results showed that the irrigation schedules did not lead to significant differences in most of the response variables (p > 0.05), except for the TNC (13.2 und), CN2 (7.4 und) and CAI (1.58 m2 m−2) of MIU. It was observed that OEM presented the highest yield, WUEFM and WUEDM (p < 0.05). Adopting the OEM clone, regardless of the irrigation schedule, is the strategy that achieves the best production.
Deep Learning and Knowledge
Authors: Gillies Donald
Published: November 2024

This paper considers the question of what kind of knowledge is produced by deep learning. Ryle’s concept of knowledge how is examined and is contrasted with knowledge with a rationale. It is then argued that deep neural networks do produce knowledge how, but, because of their opacity, they do not in general, though there may be some special cases to the contrary, produce knowledge with a rationale. It is concluded that the distinction between knowledge how and knowledge with a rationale is a useful one for judging whether a particular application of deep learning AI is appropriate.
Sprint Management in Agile Approach: Progress and Velocity Evaluation Applying Machine Learning
Authors: Pérez Castillo Yadira Jazmín , Orantes Jiménez Sandra Dinora , Letelier Torres Patricio Orlando
Published: November 2024

Nowadays, technology plays a fundamental role in data collection and analysis, which are essential for decision-making in various fields. Agile methodologies have transformed project management by focusing on continuous delivery and adaptation to change. In multiple project management, assessing the progress and pace of work in Sprints is particularly important. In this work, a data model was developed to evaluate the progress and pace of work, based on the visual interpretation of numerical data from certain graphs that allow tracking, such as the Burndown chart. Additionally, experiments with machine learning algorithms were carried out to validate the effectiveness and potential improvements facilitated by this dataset development.
Representing and Quantifying Conformational Changes of Kinases and Phosphatases Using the TSR-Based Algorithm
Authors: Milon Tarikul I. , Rauniyar Krishna , Furman Sara , Orthi Khairum H. , Wang Yingchun , Raghavan Vijay , Xu Wu
Published: November 2024

Protein kinases and phosphatases are key signaling proteins and are important drug targets. An explosion in the number of publicly available 3D structures of proteins has been seen in recent years. Three-dimensional structures of kinase and phosphatase have not been systematically investigated. This is due to the difficulty of designing structure-based descriptors that are capable of quantifying conformational changes. We have developed a triangular spatial relationship (TSR)-based algorithm that enables a unique representation of a protein’s 3D structure using a vector of integers (keys). The main objective of this study is to provide structural insight into conformational changes. We also aim to link TSR-based structural descriptors to their functions. The 3D structures of 2527 kinases and 505 phosphatases are studied. This study results in several major findings as follows: (i) The clustering method yields functionally coherent clusters of kinase and phosphatase families and their superfamilies. (ii) Specific TSR keys are identified as structural signatures for different types of kinases and phosphatases. (iii) TSR keys can identify different conformations of the well-known DFG motif of kinases. (iv) A significant number of phosphatases have their own distinct DFG motifs. The TSR keys from kinases and phosphatases agree with each other. TSR keys are successfully used to represent and quantify conformational changes of CDK2 upon the binding of cyclin or phosphorylation. TSR keys are effective when used as features for unsupervised machine learning and for key searches. If discriminative TSR keys are identified, they can be mapped back to atomic details within the amino acids involved. In conclusion, this study presents an advanced computational methodology with significant advantages in not only representing and quantifying conformational changes of protein structures but also having the capability of directly linking protein structures to their functions.
Spatiotemporal Differentiation of Land Ecological Security and Optimization Based on GeoSOS-FLUS Model: A Case Study of the Yellow River Delta in China Toward Sustainability
Authors: Han Lu , Qu Yanbo , Liang Shufeng , Shi Luyan , Zhang Min , Jia Haiyan
Published: November 2024

Land ecological security (LES) is a crucial issue pertaining to the sustainability of landscapes or land systems. Nevertheless, previous studies largely neglected the impacts of landscape structure on LES. This study, taking the Yellow River Delta (YRD) as the case area, analyzed the spatiotemporal differentiation patterns of regional LES in 19 counties (cities and districts) from 2000 to 2020 through the application of landscape metrics and employed GeoSOS-FLUS to forecast the landscape structure and corresponding land ecological security in 2030 under four different scenarios to advance sustainability. The results show that, first, landscape fragmentation and irregularity are decreasing, while aggregation and connectivity are increasing. The primary landscape change involves the transition from farmland to developed areas. Second, the LES index is rising. In 2020, about 73.68% of the research units reached level IV, while most were at level III. Third, it is projected that by 2030, the LES index will rise under all scenarios, exhibiting an eastward-declining gradient in its geographic distribution, with higher values prevailing in the eastern regions and gradually tapering off towards the west. It is expected that in the business-as-usual scenario, the proportion of LES reaching level V will be the highest. This study not only reveals the impact mechanism of the landscape structure on land ecological security but also provides an important basis for formulating scientific and rational land use planning and management strategies from the perspectives of sustainable land governance and sustainable land use.
Integrated Assessment of Metal Contamination of Soils, Sediments, and Runoff Water in a Dry Riverbed from a Mining Area Under Torrential Rain Events
Authors: Cuevas José , Faz Ángel , Martínez-Martínez Silvia , Beltrá Juan , Acosta José A.
Published: November 2024

Dry riverbeds can transport mining waste during torrential rain events, disseminating pollutants from mining areas to natural ecosystems. This study evaluates the impact of these mine wastes on soils, sediments, and runoff/pore water in the La Carrasquilla dry riverbed (southeastern Spain). An integrated approach utilizing geochemical and mineralogical techniques was employed, analyzing water, soil, and sediment samples from both the headwater and mouth of the riverbed. Soil profiles and pore water were collected at 30 cm, 60 cm, and 90 cm deep, alongside sediment and runoff water samples. The assessment of metal(loid) contamination focused on arsenic, cadmium, chromium, copper, iron, nickel, manganese, zinc, and lead, utilizing sequential extraction to evaluate metal partitioning across soil phases. Various pollution indices, including the contamination factor (Cf), pollution load index (PLI), potential ecological risk index (RI), and metal(loid) evaluation index (MEI), were employed to classify contamination levels. The highest level of contamination was reported in the headwater, which suggested anthropogenic activities linked to the presence of mining residues as the major source of metal(loid)s. However, an active deposition of As, Cd, Cu, Fe, Mn, and Zn was reported in the topsoil at the mouth. In the headwater, a quartz and muscovite-rich zone exhibited the highest Cf for Pb (1022), primarily bound to the soil residual fraction (62.8%). At the headwater and mouth, pore water showed higher concentrations of sulfate, Ca, Na, Cl, Mg, and Mn and higher salinity than acceptable limits for drinking water or irrigation established by the World Health Organization. Runoff-water metal concentrations surpassed established guidelines, with MEI values indicating significant contamination by cadmium (36.1) and manganese (19.0). These findings highlight the considerable ecological risk of Pb and underscore the need for targeted remediation strategies to mitigate environmental impacts in the Mar Menor coastal lagoon.
Necrotizing Pneumonia: A Practical Guide for the Clinician
Authors: Kapania Esha Madhu , Cavallazzi Rodrigo
Published: November 2024

While rare, necrotizing pneumonia is a severe and potentially life-threatening manifestation of lung parenchyma infection. Initially documented in the 1940s, it was a significant contributor to mortality rates in both adults and children, with figures reaching up to 45%. Despite being a disease described in the literature for decades, data on the management of necrotizing pneumonia remain limited. Most available information comes from retrospective observational cohort studies. This article aims to provide a comprehensive summary of the existing literature on the subject.
Size Classification and Material Sorting of Fine Powders with a Deflector Wheel Air Classifier and an Electrostatic Separator
Authors: Abohelwa Mohamed , Wollmann Annett , Benker Bernd , Plack Alexander , Javadi Mehran , Weber Alfred P.
Published: November 2024

In this study, a two-dimensional separation of microparticles based on their settling velocity and triboelectric charge ability is achieved using an air classifier for size fractionation and simultaneous charging, followed by an electrostatic separator. In the first part, considerations for enhancing particle classification with high sharpness and low-pressure drops are discussed through improvements in blade design investigated with CFD simulations and validated experimentally. Blades with extended lengths towards the center of the classifier prevent the formation of high-velocity vortices, thereby minimizing the back-mixing of particles and enhancing separation sharpness. This approach also reduces pressure drops associated with these flow vortices. In the second part of the study, the modified blades within the classifier are utilized for two-dimensional separation. Powders from two different materials are fed into the classification system, where particles become triboelectrically charged, mainly through collisions with the walls of the classification system components. Coarse particles are rejected at the wheel and exit the classifier, while differently charged fine particles of the two materials are directed into an electrostatic separator for material sorting. An enrichment of approximately 25–35% for both materials has been achieved on the electrodes of the separator.
Motherhood in the Making: Key Determinants of Parenthood Motivation in Young Adult Women
Authors: Vučenović Dario , Petrović Matea , Jelić Katarina
Published: November 2024

Background: Demographic changes are often prone to purely social perspectives, while individual differences are overlooked. This research examines the role of attachment and emotional intelligence in childbearing motivation. Methods: In total, 234 female students participated in an online survey, including sociodemographic data, adult attachment, emotional competencies, and parenting-related variables. Results: Statistical analyses revealed that the students express positive and negative childbearing motivation almost equally and moderately. They were both linked to religiosity and emotional management. We further explore the differences in relationship status and address the role of religious beliefs. The demographic measures identified as most important include healthcare availability for both mother and child, subsidizing housing loans or rent, and encouraging fathers to become more actively involved in the care of infants. Conclusion: These emerging trends deserve further investigation and social incentives.
Molecular Perspectives on Prostate Cancer: The Role of microRNAs in Androgen Receptor Regulation
Authors: Garibaldi-Ríos Asbiel Felipe , Rivera-Cameras Alicia , Figuera Luis E. , Zúñiga-González Guillermo Moisés , Gómez-Meda Belinda Claudia , García-Ortíz José Elías , Gallegos-Arreola Martha Patricia
Published: November 2024

Prostate cancer (PCa) is the most prevalent cancer among men globally. In addition to environmental risk factors, genetic factors play a crucial role in its development and progression, highlighting the regulation of key genes as an essential aspect. The androgen receptor gene (AR) plays a pivotal role in this disease, so its post-transcriptional regulation must be meticulously coordinated. In this review, we explore the role of microRNAs (miRNAs) in the regulation of AR in PCa, a field not yet fully investigated. We note that the AR, due to its extensive 3′UTR region, is targeted by numerous miRNAs, and that this regulation can occur at different levels: directly, indirectly, and through mutual regulation, thus amplifying the influence of these molecules on AR regulation.
Exploring the Role of Skin Pigmentation in the Thermal Regulation of Polar Bears and Its Implications in the Development of Biomimetic Outdoor Apparel
Authors: Leroy Arny , Anderson David M. , Marshall Patrick , Stark David , Beckham Haskell W.
Published: November 2024

A popular belief for why polar bears have black skin is to increase solar heat gain from solar radiation that penetrates through a translucent fur layer made of unpigmented hollow hair. To examine the relative importance of skin color on solar heat gain, we measured thermal gradients, heat flux, and solar transmittance through a polar bear pelt under solar irradiation while thermally anchored to a temperature-controlled plate set to 33 °C. We found that for 60–70% of the dorsal region of the pelt where the fur layer is thickest, solar energy cannot reach the skin through the fur (solar transmittance ≤ 3.5 ± 0.2%) and therefore skin color does not meaningfully contribute to solar heat gain. In contrast, skin pigmentation was important in the remaining areas of the pelt that were covered with thinner fur. This information was used to select commercially available materials according to their solar optical properties to build biomimetic outdoor apparel with enhanced solar heat gain by a factor of 3 compared to standard outerwear constructions.
Model-Free Filter-Based Trajectory Tracking Controller for Two-Wheeled Vehicles Through Pole-Zero Cancellation Technique
Authors: Lee Hosik , Oh Sangyoon , Kim Kyung-Soo , Kim Yonghun , Kim Seok-Kyoon
Published: November 2024

Considering the nonlinear dynamics, this paper devises an advanced position trajectory tracking controller with a model-free filter for two-wheeled vehicle (TWV) applications. The proposed technique preserves a simple structure in the form of the proportional–integral (PI) controller involving the model-free filter and nonlinearly structured feedback gains, which make the following contributions: (a) the proposed filter smooths the position and yaw angle measurements according to the first-order convergence rate without any model information; and (b) the PI control with the nonlinearly structured feedback gains robustly stabilizes the position and yaw angle errors along the desired first-order system to accomplish the trajectory tracking mission, which is obtained by the pole-zero cancellation (PZC) in the presence of modeling errors. MATLAB/Simulink was used to emulate the resulting feedback system and validate the effectiveness of the proposed technique.
Patogênese dos leiomiomas uterinos e seu impacto na fertilidade: mecanismos biológicos e abordagens terapêuticas
Authors: Silva Liliane Silveira da , Silva Neto Zélio Soares da , Ataide Marina Flora Santana , Souza Maria Luisa Gomes , Lemos Maria Clara Guedes Santos de , Santana Anna Beatriz Costa , Oliveira Larissa Lorena Santos , Dantas Maria Eduarda Vieira , Araújo Maria Elenira Chagas , Lima Ayssa Beatriz Silva Mateus , Jesus Lara Letícia Rocha de , Siebra Maria Eduarda Amaral
Published: November 2024

Introdução: Os leiomiomas uterinos, ou miomas, são tumores benignos do músculo liso uterino, frequentes em mulheres em idade reprodutiva. Compreender a patogênese dos leiomiomas, especialmente a desregulação hormonal, é crucial para um manejo adequado e para o desenvolvimento de terapias eficazes. Objetivo: Este estudo visa avaliar os fatores hormonais, a microbiota uterina e suas interações com a genética na formação e impacto dos leiomiomas sobre a fertilidade.  Metodologia: Trata-se de uma revisão de literatura que incluiu artigos originais em inglês e português, publicados entre 2019 e 2024, selecionados nas bases de dados “Medline”, “IBECS”  e  “Lilacs”  via  Biblioteca  Virtual  da  Saúde  (BVS),  utilizando  os descritores“Pathogenesis” AND “Uterine Fibroids” AND “Fertility”. Foram analisados 10 artigos  que  preenchiam  os  critérios  de  elegibilidade. Resultados: A desregulação hormonal, especialmente de estrogênio e progesterona, contribui significativamente para o crescimento dos miomas. A microbiota uterina desempenha um papel importante na resposta endometrial e na regulação da inflamação, destacando-se na patogênese. Fatores de risco, como obesidade e diabetes, aumentam a probabilidade de formação de miomas. As intervenções terapêuticas incluem miomectomia, embolização das artérias uterinas e tratamento hormonal, com a escolha das abordagens dependendo das características individuais de cada paciente. Conclusão: A integração dos fatores hormonais, genéticos e ambientais é fundamental para o manejo eficaz dos leiomiomas. Estratégias personalizadas são essenciais para otimizar os resultados e melhorar a qualidade de vida das pacientes.
Motherhood and humanization in the prison system
Authors: Santos Matheus Felipe Aguiar , Silva Yapuena Modena Castro Silveira da , Silva Juliana Mohana Castro Silveira da
Published: November 2024

Motherhood is one of the most important and transformative moments in a woman’s life. It is a period that requires extreme care and attention from the mother in order to promote the physical, psychological and social well-being of her baby. The representation of a favorable environment for pregnancy in which the mother finds herself in a situation of tranquility and well-being while nurturing a new life is not the reality in the prison system. In addition, there is the fear of separation from the child, which can be painful and harmful for both incarcerated mothers and their babies. Considering all these frustrations, fears and the history of these women, it is essential that there be a space for listening, sharing and counseling within prisons.
Os impactos da pandemia do COVID-19 no ganho de peso por crianças e adolescentes e suas repercussões no pós-pandemia: uma revisão integrativa da literatura
Authors: Teles Marina Pacheco Teles , Lima Carolina Schimidt De , Faria Caio Augusto De , Reis Caroline De Souza Reis , Matos Rafaela Amaral Matos , Scherrer Isabela Resende Silva
Published: November 2024

A obesidade infantil emergiu como uma grave preocupação de saúde global, exacerbada pela pandemia de COVID-19. Estilos de vida prejudiciais, como dietas ricas em carboidratos e gorduras saturadas, sedentarismo e aumento do tempo em frente a telas, contribuíram para um aumento significativo na obesidade entre crianças. Durante o isolamento, as mudanças nas rotinas escolares e o estresse emocional levaram a um maior consumo de alimentos não saudáveis, resultando em consequências físicas e psicológicas. Dados indicam que a pandemia pode ter elevado o número de crianças obesas, prevendo-se 75 milhões de casos até 2025. O sedentarismo e a alimentação inadequada se tornaram comuns, destacando a necessidade urgente de intervenções focadas na educação, nutrição e suporte familiar para combater a obesidade infantil. Este trabalho busca realizar uma revisão integrativa da literatura sobre os hábitos que levaram ao aumento da obesidade durante a pandemia e revisar as estratégias de prevenção e tratamento para mitigar esse problema
Síndrome da Ardência Bucal: uma revisão da literatura
Authors: Cavalcante Kaline Bereniz Marinho de Araújo , Ataíde Mayra Kettily Braga de , Silva Luiz Arthur Barbosa da
Published: November 2024

A Síndrome da ardência bucal (SAB) é conceituada como “dor orofacial idiopática com queimação intraoral ou disestesia recorrente, diariamente, por mais de 2 horas por dia e por mais de 3 meses, sem quaisquer lesões causais identificáveis, com ou sem alterações somatossensoriais. Apesar de ainda não ser totalmente compreendida, é amplamente aceito que a etiologia da SAB é complexa e multifatorial. A condição acomete predominantemente mulheres no período de peri e pós-menopausa. Do ponto de vista clínico e em relação à sintomatologia, a queixa mais utilizada pelos pacientes para descrever a SAB é a sensação de queimação na mucosa que se apresenta visivelmente intacta e com paciente apresentando achados clínicos e laboratoriais normais. A abordagem da SAB inclui tratamentos tópicos, sistêmicos e não farmacológicos. As evidências acerca das abordagens terapêuticas disponíveis ainda são escassas e os resultados dos tratamentos podem variar consideravelmente entre os pacientes. O objetivo deste estudo é revisar as informações atuais disponíveis na literatura sobre a SAB com ênfase no perfil do paciente, aspectos clínicos, critérios de diagnóstico e opções de tratamentos propostos. Esta revisão foi baseada em uma pesquisa com abordagem qualitativa e descritiva, utilizando os descritores “Síndrome da Ardência Bucal”; “Cavidade oral” e “Saúde bucal”. Destaca-se a importância do conhecimento sobre a fisiopatologia, perfil do paciente acometido, aspectos clínicos e critérios de diagnóstico e abordagens terapêuticas disponíveis para a SAB. Desta forma, a equipe envolvida terá mais ferramentas para melhorar a qualidade de vida do paciente acometido por esta condição.
A relação do freio labial com diastemas interincisivos: revisão de literatura
Authors: Oliveira Renan Icaro Neves de , Rodrigues Rodrigo Saraiva , Melo Samuel Abreu , Cidade Jessica Tuane Maia
Published: November 2024

O diastema pode trazer problemas estéticos e distúrbios funcionais e de estabilidade, como interferência fonética, dificuldade para higienizar a boca, aumentando acúmulo de biofilme, assim como elevar o risco de doenças como cárie, gengivite e periodontite. Correlacionar os aspectos clínicos que possam associar o freio labial com os diastemas interincisivos, e avaliar o prognóstico positivo da frenectomia quanto ao fechamento de diastema dos incisivos centrais. O tratamento ortodôntico é uma boa alternativa para o fechamento de diastemas, pois também pode tratar qualquer outro problema oclusal associado e ajudar a eliminar hábitos para funcionais, se houver. Para os profissionais odontólogos como: clínicos gerais, odontopediatras, ortodontistas e periodontistas, é de total importância que saibam reconhecer os aspectos morfológicos normais dos freios, e quando há característica do comprometimento funcional estético e saúde, visando saber quando deve-se realizar a intervenção.
Análise Epidemiológica dos aspectos da sífilis congênita no Distrito Federal de 2014 a 2023
Authors: Fernandes Otávio Bosi de Oliveira , Rêgo Victor Augusto Prates do , Sampaio Victor Brunno Pinheiro , Sousa Gabriel Alves Figueiredo de , Oliveira Daniel Vasconcelos de , Perissê Natália Cabral , Sandoval Ana Gabriela de Melo , Santos Henrique de Castro e , Mundim Renato Resende
Published: November 2024

Este estudo teve como objetivo analisar as características epidemiológicas dos casos de sífilis congênita no Distrito Federal de 2014 a 2023. Trata-se de uma pesquisa transversal, quantitativa e descritiva, realizada com dados secundários do Sistema de Informação de Agravos de Notificação (SINAN). A análise incluiu variáveis como faixa etária e escolaridade materna, além da evolução dos casos e o sexo dos recém-nascidos diagnosticados com sífilis congênita. Os resultados indicaram um aumento significativo no número de casos ao longo do período estudado, com maior prevalência em mães na faixa etária de 20 a 29 anos e com ensino fundamental incompleto. Observou-se que 95% dos recém-nascidos evoluíram de forma favorável, sem óbitos relacionados ao agravo. Entretanto, o grande número de dados classificados como "Ignorado/Branco" e "Não se aplica" comprometeu a análise detalhada de alguns aspectos importantes da doença, refletindo uma lacuna na qualidade das notificações. Conclui-se que a sífilis congênita permanece um desafio de saúde pública na região, sendo urgente a implementação de políticas públicas mais eficazes para a prevenção, tratamento e melhoria no preenchimento das fichas de notificação.
Dengue em Maringá: avaliação da incidência e controle entre 2019 e 2023
Authors: Assis Heloisa Giovana , Souza Cristiani Dantas de , Godinho Jacqueline
Published: November 2024

A dengue caracteriza-se como uma infecção viral transmitida aos seres humanos por meio da picada de mosquitos infectados, configurando-se como um problema de saúde pública, principalmente em países tropicais como o Brasil. O estudo direcionou-se à análise de dados epidemiológicos de dengue no município de Maringá, entre os anos de 2019 a 2023 por meio de dados disponibilizados pelo Sistema de Informação de Agravos de Notificação (SINAN). O estudo caracterizou-se como retrospectivo, descritivo, com abordagem quantitativa relacionada às características sociodemográficas (idade, sexo e raça) e características inerentes à infecção tais como sorotipo, mês de notificação e evolução clínica do paciente. Os resultados mostraram que a dengue no município de Maringá é prevalente em mulheres brancas, com idade entre 20 a 39 anos, onde 7,93% dos casos exigiu hospitalização e 98,14% dos casos progrediu para cura. Os sorotipos mais frequentes no município foram o DENV-2 em 2019 e 2020 e o DENV-1 entre 2021 e 2023, com o primeiro semestre do ano caracterizando-se como o período com maior frequência de casos. Espera-se que o presente estudo contribua para melhor compreensão da prevalência da dengue no município de Maringá, com vistas a auxiliar no planejamento de ações de vigilância e controle.
Implicações da terapia com hormônio do crescimento em crianças pequenas para idade gestacional
Authors: Lourenço Samuel Sotero , Martins Ana Júlia Alves , Paulo Isabella Tavares de , Lessa Isabella Batista Souza , Torres Patrícia Sousa Silva , Vinhas Júlia Lottermann , Mundim Renato Resende
Published: November 2024

O objetivo deste estudo foi analisar as implicações do uso da terapia com hormônio do crescimento (GH) em crianças nascidas pequenas para a idade gestacional (PIG). Foi realizada uma revisão de literatura nas bases PubMed/Medline, SciELO e VHL/LILACS, com artigos publicados de 2005 a 2023 em português, inglês ou espanhol. A pesquisa identificou que a deficiência de GH é prevalente em mais de 80% dos casos de crianças PIG, o que as coloca em risco para complicações relacionadas à baixa estatura e alterações metabólicas. A terapia de reposição hormonal com GH mostrou-se eficaz para estimular o crescimento e normalizar a estatura, além de trazer benefícios metabólicos e melhoria da composição corporal. Entretanto, o início precoce do tratamento, preferencialmente antes da puberdade, e o acompanhamento contínuo são cruciais para maximizar a eficácia e minimizar os riscos associados. Embora o tratamento seja seguro e bem tolerado, sua administração requer cautela devido ao risco potencial de malignidades em determinados subgrupos. Dessa forma, conclui-se que a terapia com GH é uma abordagem eficiente para melhorar o crescimento de crianças PIG e prevenir complicações, porém, estudos adicionais são necessários para compreender melhor seus efeitos a longo prazo.
Guía de práctica clínica para la toma de muestra de sangre venosa en pacientes adultos en México
Authors: Valdez Echeverría Raymundo David , Cuéllar Herrera Sandra , Márquez Monzón Dolores , Hernández Caballero Carolina , Valencia Rojas Silvia , Contreras Perea Juan Carlos , Aguirre Chavarría Daniel , Torres Rojo Flor Isela , Rodríguez Padilla Carolina , Galindo Fraga Arturo , Calderón Magallán Nancy M.
Published: November 2024

More than 70 % of medical decisions are based on the results of diagnostic tests from the clinical laboratory. To establish and standardize procedures and technical resources that allow for the generalization of optimal samples obtained by phlebotomy, a multidisciplinary group of experts gathered and developed Guía de práctica clínica para la toma de muestra de sangre venosa en pacientes adultos en México (Clinical Practice Guide for Venous Blood Sampling in Adult Patients in Mexico). This guide includes recommendations on requesting the exam, preparing the area, the patient's preanalytical conditions, required supplies, sample identification, use of the tourniquet, selection and disinfection of the puncture site, extraction and collection of the blood sample, recommendations for phlebotomy in patients with difficult venous access,among other procedures.
The efficacy of acupuncture in animals – Part 2 Considerations about indications, comparative studies, safety and adverse effects, legal regulations and integration with other complementary therapies
Authors: Oliveira Neide Judith Faria de , Martins Emilly Ingrid Silva , Crocomo Letícia Ferrari , Rodrigues Alexandre Oliveira , Mendes Marilda Teixeira , Silveira Elcio da
Published: November 2024

Acupuncture (AP) is practiced for centuries and involves using needles to stimulate several specific points along pathways, the meridians, to promote healing. AP can restore energy balance, or qi, which flows along meridians. This review aimed to describe evidence-based research in animal health, common indications and conditions threated, comparative studies of AP and other treatments, safety and adverse effects, regulatory and legal considerations and integration with other complementary and alternative therapies in animals. AP was effective in treating chronic pain, musculoskeletal disorders, arthritis, depression and anxiety. Monitoring response to AP requires collaboration between veterinarian and owners. As veterinary acupuncture (VA) advances, new treatment applications emerges, offering greater benefits for animals’ health and well-being. The comparative tests continues to provide compelling evidence for the positive effects on animal health. Non-traditional treatments have the potential to revolutionize the way we approach animal care and management. AP is widely accepted as a generally safe treatment when performed by a qualified veterinarian with the majority of treatments resulting in no adverse effects. With the growing recognition of holistic treatments and the potential benefits for animals, there is a clear need for a unified set of best practices and standards to administer the application of these therapies. Collaboration among veterinary professionals and acupuncturists can facilitate knowledge exchange, continued professional development, and the establishment of best practices to enhancing the care quality provided to patients.
Bem-estar na bovinocultura leiteira: revisão de literatura
Authors: Fonseca Layza Lorena Medeiros , Moura Marielly Maria Almeida , Carvalho Cinara da Cunha Siqueira , Santos Keitty Fabiany Alves , Fonseca Silvana Melissia Rabelo , Santos Jaine Aparecida dos , Mendes Anne Karoliny Fernandes , Costa Renê Ferreira , Ribeiro Joyce Costa , Santos Leandra Cristina Soares , Coutinho Juddy de Souza , Soares Renata Barbosa , Lafetá Neto Oscar Vieira , Dias Júnior Carlos Antônio , Mendes Lívia Rodrigues
Published: November 2024

A qualidade do leite é um elemento que impacta diretamente na lucratividade do leite e também na vida do consumidor, deste modo é um elemento importante para o âmbito dos animais de produção. As pesquisas de bem-estar animal são cada vez mais desenvolvidas internacionalmente, no entanto, no cenário brasileiro ainda existe resistência por parte dos produtores, que muitas vezes questionam o retorno financeiro deste tipo de investimento. Com isso, ao analisar a relação entre esses dois elementos, este artigo possui como escopo disseminar a importância do bem-estar animal e de que pesquisas sejam desenvolvidas em âmbito nacional para amparar as necessidades dos bovinos de leite de acordo com as características ambientais do Brasil. Objetivou-se com este trabalho reunir informações sobre bovinocultura leiteira e os efeitos da intensificação no bem-estar animal.
Suplementación de abejas en época de baja floración con lentejas y su efecto en la postura de la reina
Authors: López Francisco Javier Pastor , Valero Azucena Vargas , Requejo Luis Maconetzin Isidro , Cisneros Josueth Alonso Meza , Gaytán Iván Franco
Published: November 2024

En la Comarca Lagunera (región que comprende municipios de Coahuila y Durango en el Desierto Chihuahuense), se presentan sequias prolongadas por el cual las colonias de abejas melíferas manejadas se ven afectadas en cuanto a su alimentación natural, debido a esto, es necesario ofrecerles una alimentación suplementaria en las épocas críticas. Por tanto, el objetivo de este trabajo fue ofrecer un alimentico a base de lenteja para las abejas con un contenido de aminoácidos igual o superior a sus requerimientos. El estudio se realizó en el municipio de Gómez Palacio, Durango, México. Durante los meses de julio y agosto de 2024, se utilizaron ocho colmenas de abejas con reinas de la misma edad, a las cuales se le ofreció una dieta a base de harina de lenteja y maíz, la porción ofrecida fue de 100 g a la semana por colmena durante cuatro semanas consecutivas. Los resultados muestran una diferencia de consumo entre cada colmena, el promedio de consumo fue de 77.25 g por semana por colmena. Se sugiere el uso de la lenteja como fuente de proteína en época de escasez de polen. Es necesario seguir estudiando con más apicultores la aceptación de esta dieta y su efecto.
Uso de un laboratorio remoto como recurso para la disminución del impacto ambiental de la actividad experimental en asignaturas de química en educación superior
Authors: Montero-Miranda Eric
Published: November 2024

Este trabajo muestra algunos de los resultados de una tesis de postgrado en Gestión Ambiental y Desarrollo Local en el ICAP de Costa Rica, sobre el análisis del beneficio ambiental generado por la utilización del Laboratorio Remoto de Valoración Ácido-Base como un complemento a la actividad experimental presencial en los cursos de laboratorio del área de Química de la Universidad Estatal a Distancia. La metodología incluyó un diseño no experimental transversal donde se aplicó una matriz de valoración de impactos ambientales que fue completada por seis expertos, tres para el laboratorio presencial y tres en el laboratorio remoto. Este instrumento se basó en los procesos de preparación previa del laboratorio, transporte de productos químicos, desarrollo de la actividad y generación de residuos. Los resultados mostraron que, en contraste con la actividad experimental presencial, la actividad mediada por el Laboratorio Remoto presenta una significancia de impacto ambiental bajo. En conclusión, se logró estimar que en el caso particular de la actividad experimental presencial el impacto sobre el ambiente posee una significancia media, siendo la propia ejecución de esta experiencia y la generación de los residuos, los procesos que ocasionan un mayor impacto. Finalmente, el Laboratorio Remoto posee una significancia del impacto baja en todos los aspectos evaluados.
El capitalismo contemporáneo explicado científicamente según su estructura interna
Authors:   Universidad Nacional Autónoma de México, Veraza Urtuzuástegui Jorge
Published: November 2024

El presente artículo evidencia que la interrogante por la naturaleza del capitalismo contemporáneo se resuelve dividiendo el problema en dos más sencillos, en concordancia al Principio de Razón Suficiente, forjado por Leibniz tan admirado por Marx. Las nociones expuestas por Marx en su obra El capital constatan el aspecto necesario y fundamental de la respuesta; mientras que, para argumentar suficientemente dicha cuestión, se reconfiguran los conceptos de la crítica de la economía política a fin de generar otros que atiendan más al carácter específico del actual capitalismo. Asimismo, se retoma la conceptualización de medida de capital, y añade el de medida geopolítica de capital que da cuenta del Mercado Mundial hoy realizado, diversas ideas acuñadas por Marx ofrecen un contexto con el propósito de mostrar la estructura y dinámica completas del aludido capitalismo.
Countering the Matthew Effect in Massive Open Online Courses (MOOCs): Policy Recommendations to Promote Inclusive Design
Authors: Meaney Michael
Published: November 2024

Creating inclusive digital education for lifelong learning remains a goal for policymakers in the United States and the United Kingdom. As artificial intelligence (AI) accelerates labor market transformation, expanding access to skill development is crucial for the future of work. MOOCs could have revolutionized open lifelong learning to support workers without tertiary degrees, who are most vulnerable to economic dislocation. After more than a decade of high expectations, evidence suggests MOOCs have yet to fulfill this potential, instead primarily serving the already-educated population, reinforcing the "Matthew Effect."This paper argues that these outcomes result from sociotechnical system biases and constraints optimizing the MOOC ecosystem toward the well-educated. Ten policy recommendations are presented to mitigate these challenges, justified by a critical synthesis of existing literature. As MOOCs continue in their second decade, this agenda can refocus efforts to stimulate research and development supporting economic resilience among workers without tertiary education.
MANEJO DAS REAÇÕES HANSÊNICAS NA ATENÇÃO PRIMÁRIA À SAÚDE: DESAFIOS CLÍNICOS E PERSPECTIVAS PARA A PRÁTICA MÉDICA
Authors: Tereza Abreu Monteiro Ana , do Nascimento Andrade Feitosa Ankilma , Amanda Mota Seabra Cícera , Lima França Jessica
Published: November 2024

Objetivo: investigar as melhores práticas médicas para identificação e o manejo das reações hansênicas na Atenção Primária à Saúde. Método: foi adotada a metodologia de pesquisa bibliográfica. Para construção da revisão, foram utilizadas as seguintes bases de dados e periódicos: Scientific Electronic Library Online - SciELO, Biblioteca Virtual de Saúde, PubMed e Google Acadêmico. Foram selecionadas obras publicadas entre os anos de 2019 e 2024, que abordassem explicitamente a temática em questão. A análise do material coletado seguiu a técnica que inclui as etapas de leitura exploratória, seletiva, analítica e interpretativa. Resultados: Evidenciou-se que as reações hansênicas trazem desafios complexos que requerem uma atuação direcionada aos profissionais de saúde. O tratamento dessas reações pode ser realizado na própria atenção básica, dependendo da gravidade do quadro, para isso são utilizados medicamentos imunomoduladores e anti-inflamatórios. A abordagem deve ser integrada, combinando políticas de saúde, soluções comunitárias e cuidados centrados no paciente. A adesão ao tratamento da hanseníase é um desafio significativo para o sistema de saúde, tornando fundamental uma prática clínica direcionada e holística. A realização de visitas domiciliares também é essencial nesse cenário, visto que elas fortalecem o vínculo entre profissionais de saúde e pacientes. Considerações finais: Na atenção primária, a atuação médica é crucial para o diagnóstico e tratamento eficaz, garantindo acompanhamento contínuo do paciente com Hanseníase. Além disso, é importante que as práticas sigam as diretrizes do Ministério da Saúde e que haja iniciativas de educação continuada para os profissionais. Essas iniciativas devem focar no aprimoramento técnico e na capacitação científica, com o objetivo de aumentar a eficácia no controle e eliminação dessa patologia que continua sendo um grave problema de saúde pública.

Palavras-chave: Reações Hansênicas. Atenção Primária à Saúde. Manejo Clínico.