bluuebunny/crossref_metadata_2025 huggingface dataset:
How Does Organizational Career Management Benefit Employees? The Impact of the “Enabling” and “Energizing” Paths of Organizational Career Management on Employability and Job Burnout
Authors: Xie Mengying , Wang Guorui , Wu Yenchun Jim , Shi Haohua
Published: January 2023

Organizational career management (OCM) is believed to be a useful practice to stimulate the potential of employees. However, how this can be achieved is still under investigation. This research aims to explore the mechanisms that explain the effects of OCM by clarifying its impact on employees’ psychological states and their capability, based on a socially embedded model of thriving. To examine our hypotheses, we conducted a three-wave survey study with 272 full-time employees in China from diverse industries. The study lasted for three months and there was a one-month interval after each wave. We asked the participants to report OCM, career plateau and demographic variables at Time 1, their appraisal of learning and vitality at Time 2, and their self-perceived employability and job burnout at Time 3. We utilized regression analysis to examine our theoretical model and path analysis using the bias-corrected bootstrap method to test the significance of the indirect and moderation effects. The findings showed that OCM positively affected employees’ learning and vitality at work, which increased their self-perceived employability and subsequently decreased job burnout. Furthermore, the effects of OCM were found to be weaker for employees with a high degree of career plateau. These findings demonstrate that OCM benefits employees by “enabling” and “energizing” them to better themselves in terms of their employment and they shed light on the boundary condition of the career plateau. Therefore, organizations may provide OCM to facilitate employees’ capability and their motivation to engage in self-development, and to further enhance the effects by decreasing their perception of a career plateau.
Preeclampsia and Obesity—The Preventive Role of Exercise
Authors: Poniedziałek-Czajkowska Elżbieta , Mierzyński Radzisław , Leszczyńska-Gorzelak Bożena
Published: January 2023

Obesity is now recognized as a worldwide epidemic. An inadequate diet and reduced physical activity are acknowledged as the leading causes of excess body weight. Despite growing evidence that obesity is a risk factor for unsuccessful pregnancies, almost half of all women who become pregnant today are overweight or obese. Common complications of pregnancy in this group of women are preeclampsia and gestational hypertension. These conditions are also observed more frequently in women with excessive weight gain during pregnancy. Preeclampsia is one of the most serious pregnancy complications with an unpredictable course, which in its most severe forms, threatens the life and health of the mother and her baby. The early identification of the risk factors for preeclampsia development, including obesity, allows for the implementation of prophylaxis and a reduction in maternal and fetal complications risk. Additionally, preeclampsia and obesity are the recognized risk factors for developing cardiovascular disease in later life, so prophylaxis and treating obesity are paramount for their prevention. Thus, a proper diet and physical activity might play an essential role in the prophylaxis of preeclampsia in this group of women. Limiting weight gain during pregnancy and modifying the metabolic risk factors with regular physical exercise creates favorable metabolic conditions for pregnancy development and benefits the elements of the pathogenetic sequence for preeclampsia development. In addition, it is inexpensive, readily available and, in the absence of contraindications to its performance, safe for the mother and fetus. However, for this form of prevention to be effective, it should be applied early in pregnancy and, for overweight and obese women, proposed as an essential part of planning pregnancy. This paper aims to present the mechanisms of the development of hypertension in pregnancy in obese women and the importance of exercise in its prevention.
Identification of Alzheimer’s Disease by Imaging: A Comprehensive Review
Authors: T. Prasath , V. Sumathi
Published: January 2023

In developing countries, there is more concern for Alzheimer’s disease (AD) by public health professionals due to its catastrophic effects on the elderly. Early detection of this disease helps in starting the therapy soon and slows down the progression of the disease. Imaging techniques are considered to be the best solutions for its detection. Brain imaging was initially used to diagnose AD. Different techniques for identifying protein accumulation in the nervous system, a sign of Alzheimer’s disease, are identified by MRI imaging. Although they were initially attributed to cortical dysfunction, visual system impairments in Alzheimer’s patients were also found in the early 1970s. Several non-invasive approaches reported for screening, prevention, and therapy were unsuccessful. It is vitally necessary to develop new diagnostic methods in order to accurately identify patients who are in the early stages of this disease. It would be wonderful to have a quick, non-invasive, affordable, and easily scalable Alzheimer’s disease screening. Researchers may be able to identify biomarkers for Alzheimer’s disease and understand more about its aetiology with imaging and data processing. This study clarifies the need for medical image processing and analysis strategies which aid in the non-invasive diagnosis of AD.
Prevalence of Attention Deficit Hyperactivity Disorder (ADHD) among Substance Use Disorder (SUD) Populations: Meta-Analysis
Authors: Rohner Henrik , Gaspar Nikolas , Philipsen Alexandra , Schulze Marcel
Published: January 2023

(1) Background: Attention deficit hyperactivity disorder (ADHD) is characterized by a persistent pattern of age-inappropriate levels of inattention and/or hyperactivity/impulsivity that results in functional impairment at work, education, or hobbies and affects family life, social contacts, and self-confidence. ADHD is a comorbid condition associated with a prognosis of severe substance use disorder (SUD) and the early onset of such. The aim of this meta-analysis was to obtain the best estimate of the prevalence of ADHD in SUD populations. (2) Methods: A literature research was conducted using PUBMED® and Web of Science®. The following search terms were used: [ADHD], [prevalence], and [substance use disorder]. RStudio® was used for meta-analysis methods. (3) Results: In total, 31 studies were included. We estimate the prevalence of ADHD among SUD patients at 21%.
Do Higher Transcranial Direct Current Stimulation Doses Lead to Greater Gains in Upper Limb Motor Function in Post-Stroke Patients?
Authors: Pires Raylene , Baltar Adriana , Sanchez Maria Paz , Antonino Gabriel Barreto , Brito Rodrigo , Berenguer-Rocha Marina , Monte-Silva Katia
Published: January 2023

Objective: To investigate whether a higher number of transcranial direct current stimulation (tDCS) sessions results in a greater improvement in upper limb function in chronic post-stroke patients. Materials and methods: A randomized, sham-controlled, double-blind clinical trial was conducted in 57 chronic post-stroke patients (≥ 3 months after their injuries). The patients were allocated to receive sessions of tDCS combined with physiotherapy and divided into three groups (anodal, cathodal, and sham). The Fugl-Meyer Assessment of Upper Extremity (FMA-UE) was used to assess the sensorimotor impairment of the patients’ upper limbs before (baseline) and after five and ten sessions. The percentage of patients who achieved a clinically significant improvement (> five points on the FMA-UE) was also analyzed. Results: The FMA-UE score increased after five and ten sessions in both the anodal and cathodal tDCS groups, respectively, compared to the baseline. However, in the sham group, the FMA-UE score increased only after ten sessions. When compared to the sham group, the mean difference from the baseline after five sessions was higher in the anodal tDCS group. The percentage of individuals who achieved greater clinical improvement was higher in the stimulation groups than in the sham group and after ten sessions when compared to five sessions. Conclusions: Our results suggest that five tDCS sessions are sufficient to augment the effect of standard physiotherapy on upper limb function recovery in chronic post-stroke patients, and ten sessions resulted in greater gains.
The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer
Authors: Preda Mădălina , Tănase Bogdan Cosmin , Zob Daniela Luminița , Gheorghe Adelina Silvana , Lungulescu Cristian Virgil , Dumitrescu Elena Adriana , Stănculeanu Dana Lucia , Manolescu Loredana Sabina Cornelia , Popescu Oana , Ibraim Elmira , Mahler Beatrice
Published: January 2023

Lung cancer and pulmonary tuberculosis are two significant public health problems that continue to take millions of lives each year. They may have similar symptoms and, in some cases, are diagnosed simultaneously or may have a causal relationship. In tuberculosis disease, the chronic inflammation, different produced molecules, genomic changes, and fibrosis are believed to be important factors that may promote carcinogenesis. As a reverse reaction, the development of carcinogenesis and the treatment may induce the reactivation of latent tuberculosis infection. Moreover, the recently used checkpoint inhibitors are a debatable subject since they help treat lung cancer but may lead to the reactivation of pulmonary tuberculosis and checkpoint-induced pneumonitis. Pulmonary rehabilitation is an effective intervention in post-tuberculosis patients and lung cancer patients and should be recommended to improve outcomes in these pathologies.
Association between Social Participation and Remaining Teeth and Urban–Rural Difference among Older Adults in China
Authors: Yang Le , Guo Dan , Zheng Jiaming , Guo Yuting , Li Zeyuan
Published: January 2023

Oral health is an important part of older adults’ general health. The study examined the association between social participation (formal and informal) and remaining teeth and the urban–rural difference based on a national survey of older adults in China. The data of older adults were extracted from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and analyzed. A total of 11,948 respondents were ultimately involved, including 6836 urban respondents and 5112 rural respondents. Informal social participation and formal social participation were used to assess social participation. The number of remaining natural teeth was measured. Social participation was significantly associated with remaining teeth among older adults, after adjusting for confounders, a one-level increase in the informal social participation was associated with a decrease in natural teeth by 0.152 (95% CI = −0.274; −0.030) and a one-level increase in the formal social participation was associated with a decrease in natural teeth by 0.370 (95% CI = −0.585; −0.156). In addition, the association between social participation (formal and informal) and remaining teeth was observed among urban older adults, but not rural older adults. A high level of social participation may effectively decrease the risk of oral-health problems for the Chinese older adults. The findings suggest recommendations for an older adults-targeted policy and the practice of oral-health promotion. However, the urban–rural difference should be taken into full consideration in social-participation-driven oral-health promotion interventions.
Impact of Psychological Factors on Functional Performance among Patients with Chronic Obstructive Pulmonary Disease
Authors: Aldhahi Monira I. , Baattaiah Baian A. , Nazer Rakan I. , Albarrati Ali
Published: January 2023

The role of anxiety and depression in functional performance during walking in patients with chronic obstructive pulmonary disease (COPD) is controversial. In this cross-sectional study, we aimed to assess the effects of anxiety, depression, and health-related quality of life (HRQOL) on the functional performance of this patient population. Seventy COPD patients aged 63 ± 11 years participated in the study. To measure their functional performance, the six-minute walk test (6MWT) was used. Anxiety and depression were assessed using two questionnaires: the Anxiety Inventory for Respiratory Disease (AIR) scale and the Hospital Anxiety and Depression Scale (HADS). The St. George’s Respiratory Questionnaire (SGRQ) was used to assess HRQOL. Based on their anxiety levels, the patients were divided into a no anxiety group and a high anxiety group. There were no significant differences between the two groups in terms of pulmonary function profile or smoking status. The mean AIR and HADS (depression) scores were high (12.78 ± 4.07 and 9.90 ± 3.41, respectively). More than one-third of the patients (46%) reported high anxiety levels (above the standard cutoff score of 8). The mean score of the aggregated HADS scale was significantly higher in the high anxiety group (20.87 ± 6.13) than in the no anxiety group (9.26 ± 4.72; p = 0.01). Patients with high anxiety had poorer functional performance (6MWT: 308.75 ± 120.16 m) and HRQOL (SGRQ: 56.54 ± 22.36) than patients with no anxiety (6MWT: 373.76 ± 106.56 m; SGRQ: 42.90 ± 24.76; p < 0.01). The final multivariate model explained 33% of the variance in functional performance after controlling for COPD severity (F = 8.97). The results suggest that anxiety, depression, and poor health status are significantly associated with poor functional performance. This study highlights the need to screen patients with COPD at all stages for anxiety and depression.
Reflection and Foresight on Personal Information Protection and Optimization in Public Health Emergencies in China—From the Perspective of Personal Information Collection during the Period of China’s Dynamic-Zero COVID-19 Prevention and Control Policy
Authors: Wang Huimin
Published: January 2023

Public health emergencies threaten the overall public health security of the country. Based on the need to control the ways of infection, the collection and processing of personal information by the government have become an important part of epidemic prevention and control. However, personal information related to the epidemic is highly sensitive, which contains other personal information and even private information in addition to information on personal health. In the early days of China’s response to the public health emergency of COVID-19, a great deal of non-desensitized information was transmitted in an unaccredited manner. With the implementation of epidemic prevention and control measures, the collection and processing of personal information in China have gradually transited from the initial disorder and chaos to the current orderly, legal, and effective situation, continuously optimizing the processing paths of personal information. Serious summary and reflection on the optimization path of China’s epidemic-related information collection and processing methods by looking for a border at which the way and scope of personal information disclosure in future major public health emergencies are compatible with its purpose and role may help to improve the development of China’s personal information protection legal system from a long-term perspective.
The Amount of Light to Vigorous Physical Activity (Met’s-Hours/Day) in Children with and without Down Syndrome Attending Elementary School in Japan
Authors: Yamanaka Erika , Inayama Takayo , Okazaki Kanzo , Nakada Tsubasa , Kojima Michio , Kita Ichiro , Ohkawara Kazunori
Published: January 2023

Children with Down syndrome (DS) have physical characteristics such as hypotonus of the musculature. Therefore, their attainment rate of physical activity guidelines is low, and guidelines alone may not be sufficient in assessing the amount of physical activity in children with DS. Compared with normal children (NC) of the same grade, light physical activity (LPA) must be considered while assessing physical activity of children with DS, owing to muscle hypotonia. This study included 69 children with DS and 68 NC in grades 4–6 attending elementary school in Japan. The measurements for physical characteristics included age, height, weight, and body mass index. Physical activity was measured using a triaxial accelerometer, which indicated physical activity volume. Children with DS had less moderate-to-vigorous physical activity duration (DS: 53.1 min/day, NC: 65.0 min/day; p < 0.001) but significantly longer LPA duration (DS: 376.4 min/day, NC: 287.7 min/day; p < 0.001) than NC. Conversely, the amount of light to vigorous physical activity (Met’s-hours/day) was greater in children with DS (DS: 16.0 Met’s-hours/day, NC: 14.4 Met’s-hours/day; p = 0.037). In children with DS with muscular hypotonia, vigorous physical activity is challenging, but LPA is feasible. Developing and validating educational programs that promote physical activity with intensity level depending on individual’s physical characteristic are warranted.
Association of Psychosocial Factors on COVID-19 Testing among YWCA Service Recipients
Authors: Blasingame Miaya , Mallett Veronica , Cook Mekeila , Im Wansoo , Wilus Derek , Kimbrough Robin , Ikwuezunma Gini , Orok Ekemini , Reed Breia , Akanbi Victoria , Amoo-Asante Aurdie , Sanderson Maureen
Published: January 2023

The purpose of this study was to examine how psychosocial factors affect receipt of COVID-19 testing among Black and Hispanic women. In this cross-sectional study of Black and Hispanic women who received services from the YWCAs in Atlanta, El Paso, Nashville, and Tucson between 2019 and 2021 (n = 662), we used Patient-Reported Outcomes Measurement Information Systems (PROMIS) item bank 1.0 short forms to examine the impact of psychosocial factors (i.e., depression, anxiety, social isolation, instrumental support, emotional support, and companionship) on COVID-19 testing. Multivariable logistic regression models were used to estimate odds ratios and 95% confidence intervals for receipt of a COVID-19 test associated with psychosocial factors while adjusting for confounders. There was little effect of moderate/severe depressions or anxiety on receipt of COVID-19 testing. Black (odds ratio [OR] 0.58, 95% confidence interval [CI] 0.26–1.29) and Hispanic (OR 0.61, 95% CI 0.38–0.96) women with high levels of emotional support were less likely to receive the COVID-19 test. While high levels of instrumental support was associated with less likely receipt of the COVID-19 test among Black women (OR 0.75, 95% CI 0.34–1.66), it was associated with more likely receipt among Hispanic women (OR 1.19, 95% CI 0.74–1.92). Our findings suggest that certain psychosocial factors influence one’s decision to get a COVID-19 test which can be useful in encouraging preventive healthcare such as screening and vaccination.
Chronic Kidney Disease and Periodontitis Interplay—A Narrative Review
Authors: Baciu Sorana Florica , Mesaroș Anca-Ștefania , Kacso Ina Maria
Published: January 2023

Periodontitis (PO), a chronic microbially-induced inflammation of the supporting tissues of the tooth, is linked to various systemic diseases. We analyze its bidirectional relationship to chronic kidney disease (CKD), a major health-care problem with impressive excess mortality. Overwhelming associative relationship between CKD and PO are analyzed. Major pathophysiologic mechanisms that link CKD to PO are then presented: systemic inflammation, endothelial dysfunction, and imbalance of oxidative stress characteristic of CKD have a role in PO development and might influence escape mechanisms of oral microbiota. Subclinical local and systemic inflammation induced by PO might influence in turn CKD outcomes. Homeostatic changes induced by CKD such as mineral bone disorders, acidosis, uremic milieu, or poor salivary flow are also relevant for the occurrence of PO. There is insufficient evidence to recommend a standardized diagnostic and therapeutic approach regarding association of PO to CKD.
Are Women More Vulnerable to Flooding Than Men in an Aging Japanese Society?
Authors: Fan Juan , Huang Guangwei
Published: January 2023

It is a well-accepted notion that women are more vulnerable to natural disasters than men, especially in developing countries. However, in developed countries, how women’s empowerment by economic and social development has reduced the gender gap in vulnerability remains insufficiently answered. As Japan passed its golden age, moving into an aging society, a study on how the gender difference in flood vulnerability has evolved can contribute to a better understanding of the types and causes of vulnerability, leading to better flood risk management in a new social context. Following this thinking, the present study conducted a longitudinal analysis using representative flooding cases in Japan over a period of forty years. It found that the women’s fatality rate increased with age much faster than men’s in the 1980s but reversed in a recent major flood disaster. It also revealed that most flood disaster victims were elderly in recent years. These findings suggest that the flood vulnerability at present is more driven by age-related physical ability decline, much less relevant to gender. Based on the results, it proposed a new framework for assessing flood vulnerability in an aging society. Such outcomes can help with the better formulation of flood management policies and probing into solutions.
Laser Surgical Approach of Upper Labial Frenulum: A Systematic Review
Authors: Inchingolo Angelo Michele , Malcangi Giuseppina , Ferrara Irene , Viapiano Fabio , Netti Anna , Buongiorno Silvio , Latini Giulia , Azzollini Daniela , De Leonardis Nicole , de Ruvo Elisabetta , Mancini Antonio , Rapone Biagio , Venere Daniela Di , Patano Assunta , Avantario Pasquale , Tartaglia Gianluca Martino , Lorusso Felice , Scarano Antonio , Sauro Salvatore , Fatone Maria Celeste , Bordea Ioana Roxana , Inchingolo Francesco , Inchingolo Alessio Danilo , Dipalma Gianna
Published: January 2023

An abnormal and hypertrophied upper labial frenulum (ULF) can cause diastemas, gingival recession, eruption abnormalities, and the onset of carious and periodontal problems in the upper central incisors, as well as aesthetic and functional disorders of the upper lip. The goal of this investigation is to review the evidence on the surgical techniques that are currently available for treating ULF in order to identify the best approach. PubMed, Scopus, Cochrane Library, and Embase were searched for papers that matched our topic from 13 November 2012 up to 22 November 2022 using the following Boolean keywords: “frenulum” and “surgery*”. A total of eight articles were selected for the purpose of the review. ULF can be surgically treated using either traditional scalpel surgery or laser surgery. The latter is the better option due to its intra- and post-operative benefits for both the patients and the clinicians, in terms of faster healing, fewer side effects and discomfort, and greater patient compliance. However, a higher learning curve is required for this technique, especially to calibrate the appropriate power of the laser. To date, it is not possible to identify which type of laser achieves the best clinical results for the treatment of ULF.
The Effectiveness of Mental Health First Aid Training among Undergraduate Students in Switzerland: A Randomized Control Trial
Authors: Dzemaili Shota , Pasquier Jérôme , Oulevey Bachmann Annie , Mohler-Kuo Meichun
Published: January 2023

Half to three-fourths of mental disorders appear during adolescence or young adulthood, and the treatment gap is mainly due to lack of knowledge, lack of perceived need, and the stigmatization of mental illness. The aims of this study were to implement and evaluate a Mental Health First Aid (MHFA) training program among undergraduates. Participants were second-year students from two universities in the French-speaking region of Switzerland (N = 107), who were randomly assigned to an intervention group (n = 53) or control group (n = 54). The intervention group received a 12-h MHFA course. Online questionnaires were completed before the intervention (T0), and both 3 months (T1) and 12 months (T2) after the intervention in order to evaluate the participants’ mental health knowledge, recognition of schizophrenia, and attitudes and behaviors towards mental illness. We used Generalized Estimating Equations (GEE) to examine the effects of intervention over time. After the MHFA course, the intervention group showed significantly increased basic knowledge and confidence helping others with mental illness and reduced stigmatization at both T1 and T2 compared to their baseline scores and compared to control groups. This suggests that the MHFA training program is effective and has significant short-term and long-term impacts, in terms of enhancing basic knowledge about mental health and improving attitudes towards mental illness among undergraduate students.
Efficient Removal of Heavy Metals from Contaminated Sunflower Straw by an Acid-Assisted Hydrothermal Process
Authors: Song Huijuan , Zhou Jun , He Shilong , Ma Qiao , Peng Liang , Yin Miaogen , Lin Hui , Zeng Qingru
Published: January 2023

The removal of heavy metals is crucial to the utilization of contaminated biomass resources. In this study, we report an efficient process of hydrothermal conversion (HTC) of sunflower straw (Helianthus annuus L.) to remove heavy metals. The effect of different HTC temperatures and concentrations of HCl additives on heavy metal removal efficiency was investigated. The results revealed that increasing the temperature or concentration of HCl promoted the transfer of heavy metals from hydrochar to liquid products during HTC. The heavy metals removed to the liquid products included up to 99% of Zn and Cd, 94% of Cu, and 87% of Pb after hydrothermal conversion with a temperature of 200 °C and HCl 2%. The species of heavy metals in hydrochars converted from unstable to stable with an increase in temperature from 160 °C to 280 °C. The stable fractions of heavy metals in the acidic condition decreased as the acid concentration increased. This aligns well with the high transfer efficiency of heavy metals from the solid phase to the liquid phase under acidic conditions. The FTIR indicated that the carboxy and hydroxy groups decreased significantly as the temperature increased and the concentration of HCl increased, which promoted the degradation of sunflower straw. A scan electron microscope showed that the deepening of the destruction of the initial microstructure promotes the transfer of heavy metals from hydrochars to liquid phase products. This acid-assisted hydrothermal process is an efficient method to treat biomass containing heavy metals.
Living in an Age-Friendly Community: Evidence from a Masterplanned Development in Southwest Sydney
Authors: Jones Alasdair , Parham Susan
Published: January 2023

This paper is situated at the interface of a growing urban studies literature concerned with ‘masterplanning’ practices in urban planning and another, hitherto relatively discrete, body of research concerned with age-friendly cities and communities. The authors are interested in exploring a gap in aging in place literature around how neighbourhoods and residential settings developed with aging in place principles in mind are experienced and perceived by residents. To explore this research gap, the authors analyse qualitative (primarily interview and focus group) data collected in Park Central, a masterplanned development located in the Campbelltown suburb in the southwest region of the Sydney metropolitan area, Australia. This development was delivered in response to a need identified by the state’s land and property development agency, Landcom, for more diverse and affordable medium-density housing in Campbelltown. In particular, a need was identified for housing developments that would be able to sustainably accommodate the changing lifestyle needs of a maturing population in the region. Drawing on our thematic analysis of our data, we discern three key themes in research participants’ experiences of Park Central as a place for aging. These themes are elaborated via recourse to excerpts from our data and discussed with a view to informing how the conception, development and practice of further age-friendly communities is approached.
Prevalence of Dry Eye Symptoms and Associated Risk Factors among University Students in Poland
Authors: Wróbel-Dudzińska Dominika , Osial Natalia , Stępień Piotr Witold , Gorecka Adrianna , Żarnowski Tomasz
Published: January 2023

Aim: The aim of the study was to demonstrate the prevalence and risk factors of dry eye symptoms (DES) among university students in Poland. Material and methods: A cross-sectional study survey was conducted among 312 Polish university students. The questionnaire consisted of the Ocular Surface Disease Index (OSDI), the 5-Item Dry Eye Questionnaire (DEQ-5) and questions regarding medical history and risk factors. Results: According to the OSDI, more than half of respondents (57.1%) have symptoms of ocular surface disease. Time spent using electronic devices is correlated with scores gathered in both OSDI and DEQ-5 (p < 0.001). There is a statistically significant dependence between psychotropics (p = 0.002), glucocorticosteroids usage (p = 0.026), the presence of depression (p < 0.001), diabetes (p = 0.01) or allergy (p = 0.008) and dry eye symptoms proved in both questionnaires. Respondents with refractive errors and those living in metropolitan areas have a statistically higher symptom intensity(p < 0.022). Stress felt by students is associated with higher DES risk. No correlation between DES and smoking habits was observed. The history of SARS-CoV-2 infection was associated with the severity of DES (p = 0.036). Conclusion: Pathogenesis of DES is multifactorial and its severity depends on several factors, both genetic and environmental. Its prevalence among the young population is underestimated. Determining risk factors will enable the implementation of appropriate prophylaxis and early diagnosis.
Heat Adaptation among the Elderly in Spain (1983–2018)
Authors: Navas-Martín Miguel Ángel , López-Bueno José Antonio , Ascaso-Sánchez María Soledad , Follos Fernando , Vellón José Manuel , Mirón Isidro Juan , Luna María Yolanda , Sánchez-Martínez Gerardo , Linares Cristina , Díaz Julio
Published: January 2023

The capacity for adaptation to climate change is limited, and the elderly rank high among the most exposed population groups. To date, few studies have addressed the issue of heat adaptation, and little is known about the long-term effects of exposure to heat. One indicator that allows the ascertainment of a population’s level of adaptation to heat is the minimum mortality temperature (MMT), which links temperature and daily mortality. The aim of this study was to ascertain, firstly, adaptation to heat among persons aged ≥ 65 years across the period 1983 to 2018 through analysis of the MMT; and secondly, the trend in such adaptation to heat over time with respect to the total population. A retrospective longitudinal ecological time series study was conducted, using data on daily mortality and maximum daily temperature across the study period. Over time, the MMT was highest among elderly people, with a value of 28.6 °C (95%CI 28.3–28.9) versus 28.2 °C (95%CI 27.83–28.51) for the total population, though this difference was not statistically significant. A total of 62% of Spanish provinces included populations of elderly people that had adapted to heat during the study period. In general, elderly persons’ level of adaptation registered an average value of 0.11 (°C/decade).
Global Trends in Green Space and Senior Mental Health Studies: Bibliometric Review
Authors: Wu Xialu , Shen Yu-Sheng , Cui Shenghui
Published: January 2023

The Sustainable Development Goals and the World Health Organization have prioritized senior mental health as an important goal. Senior mental health is a critical issue within the global public health sphere. Notably, green spaces are a useful alternative for improving senior mental health. Many studies have focused on green space and senior mental health, especially on their connection and relationship. However, this research topic lacks a comprehensive and systematic review. Owing to the lack of critical reviews, this study clarified the trend, progress, status, and focus of studies on green spaces and senior mental health using bibliometric analysis of literature within the Web of Science database. The literature analysis within this study specifically focused on the following, including the country/region contribution analysis, institution contribution analysis, keyword analysis, and highly productive journal analysis. Furthermore, this study systematically recorded the content of green space and senior mental health, identified the gap that exists, and provided future frontier directions or issues for research. These contribute toward comprehending the progress and content of this research topic and further provide a guide, reference, and inspiration for possible future research.
Haptic and Force Feedback Technology in Dental Education: A Bibliometric Analysis
Authors: Hsu Min-Hsun , Chang Yu-Chao
Published: January 2023

The haptic and force feedback technology has received an increasing attention in dental schools due to its effectiveness in psychomotor skill training. However, the bibliometric analysis on haptic and force feedback technology in dental education is still scarce. Therefore, the aim of this study was to perform a bibliometric analysis of the development of haptic and force feedback technology and its changing trends in dental education. From 1 January 2001 to 30 November 2022, all papers published on haptic and force feedback technology were searched from the Web of Science Core Collection database. These data were then entered into Apple Numbers for descriptive bibliometric analysis and visualized using VOSviewer software. A total of 85 articles were retrieved following the inclusive and exclusive criteria. The results demonstrated that USA and China exhibited the most publications. The combination of correspondence author and author co-citation analysis identified the more prominent authors in this research field. The top-cited and the average citation count per year ranking led to different views of popularity. A significant increase in the number of haptic and force feedback technology publications were found in the last two years. Virtual reality is the main keyword that indicates more new integrative applications currently underway. Taken together, this study provides a detailed bibliographic analysis of haptic and force feedback technology in dental education to indicate representative authors, literatures, keywords, and trends. These detailed data will help researchers, teachers, and dental students as a very useful information when trying to make haptic and force feedback technology more prevalent in dental education in the near further.
Relationship between Body Composition and Specific Motor Abilities According to Position in Elite Female Soccer Players
Authors: Stanković Mima , Čaprić Ilma , Đorđević Dušan , Đorđević Stefan , Preljević Adem , Koničanin Admira , Maljanović Džejla , Nailović Hamza , Muković Iso , Jelaska Igor , Sporiš Goran
Published: January 2023

Contemporary top-division soccer is characterized by high-intensity activity throughout the entire match, which also requires high levels of a wide range of the players’ functional and motor abilities. Furthermore, motor and functional requirements vary in relation to the players’ position on the pitch. In view of the above, the objective of this study was to determine any differences in body composition and specific motor abilities in relation to position. Twenty elite female soccer players (age: 20.90 ± 3.70 years; height: 166.95 ± 5.83 cm; weight: 58.97 ± 7.50 kg; training experience: 9.50 ± 4.11 years) were recruited for the purpose of this study. Based on their position within the team, the players were divided into three groups: defenders (N-7), midfielders (N-6), and forwards (N-7). The instruments used included the InBody770 (for body composition assessment), Optojump and Polar for the assessment of specific motor abilities. The results obtained indicate a strong link between the parameters body composition and specific motor abilities; however, the level of significance varies, as do the variables concerning specific motor abilities and body composition in relation to the players’ position on the pitch. In accordance with these results, coaches and others working in the soccer industry should be apprised of the necessity of a tailored approach when it comes to planning the development of specific motor abilities, as well of with the importance of balanced body composition as prerequisites for achieving top results.
Public Engagement in Digital Recommendations for Promoting Healthy Parental Behaviours from Preconception through the First 1000 Days
Authors: Cinelli Giulia , Croci Ileana , Gesualdo Francesco , Pandolfi Elisabetta , Miller Kiersten Pilar , Tozzi Alberto Eugenio
Published: January 2023

Web-based digital interventions may play a central role for health promoting strategies in the first “1000 days”, from conception through the first 2 years of life. We developed a web platform providing evidence-based recommendations in the first 1000 days through short videos, and we studied engagement by users from preconception through parenthood in the second year of life. We described the access to videos by topic and used a multilevel model to explore the user characteristics associated with access to the video recommendations. Overall, breastfeeding, physical activity and nutrition were the most popular topics (normalized views: 89.2%, 87.2% and 86.4% respectively), while content on paternal health and smoking and alcohol was less engaging (37.3% and 42.0%). Nutrition content was the most viewed in the preconception period and during the first two trimesters of pregnancy. Nutrition and breastfeeding were also the most popular topics for users with children less than 2 years old. Higher levels of health literacy were associated only with child health content. The study findings indicate that digital strategies should be adapted according to the time period in the first 1000 days. Alternative digital promotion strategies for the less engaging topics should be considered.
Measuring Metro Accessibility: An Exploratory Study of Wuhan Based on Multi-Source Urban Data
Authors: Wu Tao , Li Mingjing , Zhou Ye
Published: January 2023

Metro accessibility has attracted interest in sustainable transport analyses. Hence, the accuracy of metro-accessibility measures have become increasingly vital. Various spatiotemporal factors, including by-metro accessibility, land-use accessibility and to-metro accessibility, affect metro accessibility; however, measuring metro accessibility while considering all these components simultaneously is challenging. By integrating these factors into a unified analysis framework, this study aims to strengthen the method for metro-accessibility assessment. Specifically, we proposed the “By metro–Land use–To metro” model to conduct a metro-accessibility index and develop an accessibility-based station typology. The results show that Wuhan metro system accessibility presented a “high-medium-low” spatial disparity from the urban center to the periphery. Meanwhile, the variety of metro-accessibility characteristics and typologies in Wuhan will equip urban planners and policymakers with a useful tool for better organising by-metro accessibility, land-use accessibility and to-metro accessibility.
Automatic Clustering of Indoor Area Features in Shopping Malls
Authors: Gao Ziren , Shen Yi , Ma Jingsong , Shen Jie , Zheng Jing
Published: January 2023

The comprehensive expression of indoor maps directly affects the visualization effect of the map and the user’s map reading experience. Currently, only the points, lines, and polygons of outdoor maps are used as objects of cartographic generalization. Therefore, this study considers indoor map area features as generalization objects and deems the automatic clustering of the indoor area features of shopping malls as the research goal. The approach is used to construct an encoder-decoder clustering model, where the encoder consists of a graph convolutional network and its variant models. The results show that the proposed model framework effectively extracts the area features suitable for the indoor space clustering of shopping malls and improves clustering efficacy. Specifically, the model with the Relational Graph Convolutional Network as the encoder demonstrated the best performance, time complexity, and accuracy of clustering results, with accuracy up to 95%. This study extends the research object of cartographic generalization to indoor maps, enabling the automatic clustering of indoor area features, and proposes a clustering model for the important indoor scene of shopping malls. This is valuable for scholars interested in the cartographic generalization of indoor maps.
The Bright Side of Psychedelics: Latest Advances and Challenges in Neuropharmacology
Authors: Mastinu Andrea , Anyanwu Margrate , Carone Marinella , Abate Giulia , Bonini Sara Anna , Peron Gregorio , Tirelli Emanuela , Pucci Mariachiara , Ribaudo Giovanni , Oselladore Erika , Premoli Marika , Gianoncelli Alessandra , Uberti Daniela Letizia , Memo Maurizio
Published: January 2023

The need to identify effective therapies for the treatment of psychiatric disorders is a particularly important issue in modern societies. In addition, difficulties in finding new drugs have led pharmacologists to review and re-evaluate some past molecules, including psychedelics. For several years there has been growing interest among psychotherapists in psilocybin or lysergic acid diethylamide for the treatment of obsessive-compulsive disorder, of depression, or of post-traumatic stress disorder, although results are not always clear and definitive. In fact, the mechanisms of action of psychedelics are not yet fully understood and some molecular aspects have yet to be well defined. Thus, this review aims to summarize the ethnobotanical uses of the best-known psychedelic plants and the pharmacological mechanisms of the main active ingredients they contain. Furthermore, an up-to-date overview of structural and computational studies performed to evaluate the affinity and binding modes to biologically relevant receptors of ibogaine, mescaline, N,N-dimethyltryptamine, psilocin, and lysergic acid diethylamide is presented. Finally, the most recent clinical studies evaluating the efficacy of psychedelic molecules in some psychiatric disorders are discussed and compared with drugs already used in therapy.
The Machinery of Exosomes: Biogenesis, Release, and Uptake
Authors: Krylova Sofia V. , Feng Daorong
Published: January 2023

Exosomes are a subtype of membrane-contained vesicles 40–200 nm in diameter that are secreted by cells into their surroundings. By transporting proteins, lipids, mRNA, miRNA, lncRNA, and DNA, exosomes are able to perform such vital functions as maintaining cellular homeostasis, removing cellular debris, and facilitating intercellular and interorgan communication. Exosomes travel in all body fluids and deliver their molecular messages in autocrine, paracrine as well as endocrine manners. In recent years, there has been an increased interest in studying exosomes as diagnostic markers and therapeutic targets, since in many disease conditions this machinery becomes dysregulated or hijacked by pathological processes. Additionally, delivery of exosomes and exosomal miRNA has already been shown to improve systemic metabolism and inhibit progression of cancer development in mice. However, the subcellular machinery of exosomes, including their biogenesis, release and uptake, remains largely unknown. This review will bring molecular details of these processes up to date with the goal of expanding the knowledge basis for designing impactful exosome experiments in the future.
FISH Diagnostic Assessment of MDM2 Amplification in Liposarcoma: Potential Pitfalls and Troubleshooting Recommendations
Authors: Gambella Alessandro , Bertero Luca , Rondón-Lagos Milena , Verdun Di Cantogno Ludovica , Rangel Nelson , Pitino Chiara , Ricci Alessia Andrea , Mangherini Luca , Castellano Isabella , Cassoni Paola
Published: January 2023

MDM2 amplification represents the leading oncogenic pathway and diagnostic hallmark of liposarcoma, whose assessment is based on Fluorescence In Situ Hybridization (FISH) analysis. Despite its diagnostic relevance, no univocal interpretation criteria regarding FISH assessments of MDM2 amplification have been established so far, leading to several different approaches and potential diagnostic misinterpretations. This study aims to address the most common issues and proposes troubleshooting guidelines for MDM2 amplification assessments by FISH. We retrospectively retrieved 51 liposarcomas, 25 Lipomas, 5 Spindle Cell Lipoma/Pleomorphic Lipomas, and 2 Atypical Spindle Cell Lipomatous Tumors and the corresponding MDM2 FISH analysis. We observed MDM2 amplification in liposarcomas cases only (43 out of 51 cases) and identified three MDM2-amplified patterns (scattered (50% of cases), clustered (14% of cases), and mixed (36% of cases)) and two nonamplified patterns (low number of signals (82% of cases) and polysomic (18% of cases)). Based on these data and published evidence in the literature, we propose a set of criteria to guide MDM2 amplification analysis in liposarcoma. Kindled by the compelling importance of MDM2 assessments to improve diagnostic and therapeutic liposarcoma management, these suggestions could represent the first step to develop a univocal interpretation model and consensus guidelines.
The Role of ATP-Binding Cassette Subfamily A in Colorectal Cancer Progression and Resistance
Authors: Alketbi Latifa , Al-Ali Abeer , Talaat Iman M. , Hamid Qutayba , Bajbouj Khuloud
Published: January 2023

Colorectal cancer (CRC) is one of the most common malignancies worldwide; it is the fourth leading cause of cancer-related deaths. CRC arises due to mutations that can affect oncogenes, tumour suppressor genes and DNA repair genes. The lack of novel diagnostic and therapeutic targets and the development of chemoresistance are some of the major issues when dealing with CRC. The overexpression of ATP-binding cassette (ABC) transporters is considered one facilitating mechanism for chemoresistance. Furthermore, ABC transporters have additional roles in cancer development beyond multidrug resistance. In CRC, lipid dysregulation has a key role in tumour development and progression, as cancer cells rely on lipids for energy and rapid cell proliferation. ABC subfamily A (ABCA) contains the largest members of ABC proteins, mainly known for their role in lipid transport, mostly membrane lipids such as cholesterol and phospholipids. Although the exact mechanism of action of these members is not confirmed, their expression is usually correlated with tumour progression and therapy resistance, probably due to their role in lipid homeostasis. CRC shows alteration in the expression of ABCA transporters, which is usually linked to poor prognosis and overall survival. Therefore, as lipid transporters, their role in CRC is investigated, and their diagnostic and prognostic potential is evaluated. This minireview presents evidence from various studies suggesting that ABCA transporters might have an active role in CRC and can be utilized as potential diagnostic and therapeutic targets.