bluuebunny/crossref_metadata_2025 huggingface dataset:
Bisphenol S Impairs Oestradiol Secretion during In Vitro Basal Folliculogenesis in a Mono-Ovulatory Species Model
Authors: Vignault Claire , Cadoret Véronique , Jarrier-Gaillard Peggy , Papillier Pascal , Téteau Ophélie , Desmarchais Alice , Uzbekova Svetlana , Binet Aurélien , Guérif Fabrice , Elis Sebastien , Maillard Virginie
Published: August 2022

Bisphenol S (BPS) affects terminal folliculogenesis by impairing steroidogenesis in granulosa cells from different species. Nevertheless, limited data are available on its effects during basal folliculogenesis. In this study, we evaluate in vitro the effects of a long-term BPS exposure on a model of basal follicular development in a mono-ovulatory species. We cultured ovine preantral follicles (180–240 μm, n = 168) with BPS (0.1 μM (possible human exposure dose) or 10 μM (high dose)) and monitored antrum appearance and follicular survival and growth for 15 days. We measured hormonal secretions (oestradiol (at day 13 [D13]), progesterone and anti-Müllerian hormone [D15]) and expression of key follicular development and redox status genes (D15) in medium and whole follicles, respectively. BPS (0.1 µM) decreased oestradiol secretion compared with the control (−48.8%, p < 0.001), without significantly impairing antrum appearance, follicular survival and growth, anti-Müllerian hormone and progesterone secretion and target gene expression. Thus, BPS could also impair oestradiol secretion during basal folliculogenesis as it is the case during terminal folliculogenesis. It questions the use of BPS as a safe BPA substitute in the human environment. More studies are required to elucidate mechanisms of action of BPS and its effects throughout basal follicular development.
Recent Updates on mRNA Vaccines
Authors: Sydow Emily , Mustafa Abu Salim , Hanif Asma , Tunio Javed , Hanif Shumaila Nida Muhammad
Published: August 2022

Messenger RNA has been studied by everyone, from vaccine developers to high school biology students, since the discovery of its isolation in 1961 [...]
The Evolution of Medical Countermeasures for Ebola Virus Disease: Lessons Learned and Next Steps
Authors: Crozier Ian , Britson Kyla A. , Wolfe Daniel N. , Klena John D. , Hensley Lisa E. , Lee John S. , Wolfraim Larry A. , Taylor Kimberly L. , Higgs Elizabeth S. , Montgomery Joel M. , Martins Karen A.
Published: August 2022

The Ebola virus disease outbreak that occurred in Western Africa from 2013–2016, and subsequent smaller but increasingly frequent outbreaks of Ebola virus disease in recent years, spurred an unprecedented effort to develop and deploy effective vaccines, therapeutics, and diagnostics. This effort led to the U.S. regulatory approval of a diagnostic test, two vaccines, and two therapeutics for Ebola virus disease indications. Moreover, the establishment of fieldable diagnostic tests improved the speed with which patients can be diagnosed and public health resources mobilized. The United States government has played and continues to play a key role in funding and coordinating these medical countermeasure efforts. Here, we describe the coordinated U.S. government response to develop medical countermeasures for Ebola virus disease and we identify lessons learned that may improve future efforts to develop and deploy effective countermeasures against other filoviruses, such as Sudan virus and Marburg virus.
Adapting Simon’s Two-Stage Design for Efficient Screening of Filovirus Vaccines in Non-Human Primates
Authors: Niemuth Nancy A. , Sabourin Carol L. , Ward Lucy A.
Published: August 2022

The cynomolgus monkey (Macaca fascicularis) non-human primate (NHP) is widely used for filovirus vaccine testing. To use limited BSL-4 resources efficiently and minimize NHP usage, Simon’s two-stage design was adapted to screen candidate Ebola virus (EBOV) vaccines in up to six NHPs with two (optimal), three, or four NHPs in Stage 1. Using the optimal design, two NHPs were tested in Stage 1. If neither survived, the candidate was rejected. Otherwise, it was eligible for Stage 2 testing in four NHPs. Candidates advanced if four or more NHPs were protected over both stages. An 80% efficacious candidate vaccine had 88.5% probability of advancing, and a 40% efficacious candidate vaccine had 83% probability of rejection. Simon’s two-stage design was used to screen 27 EBOV vaccine candidates in 43 candidate regimens that varied in dose, adjuvant, formulation, or schedule. Of the 30 candidate regimens tested using two NHPs in Stage 1, 15 were rejected, nine were withdrawn, and six were tested in Stage 2. All six tested in Stage 2 qualified to advance in the product development pipeline. Multiple regimens for the EBOV vaccines approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) in 2019 were tested in this program. This approach may also prove useful for screening Sudan virus (SUDV) and Marburg virus (MARV) vaccine candidates.
Population Pharmacodynamic Analyses of Human Anti-Rabies Virus Monoclonal Antibody (Ormutivimab) in Healthy Adult Subjects
Authors: Zhang Junnan , Shi Nianmin , Li Guohua , Li Li , Bai Yunhua , Yang Liqing , Zhao Weimin , Gao Jian , Wei Jingshuang , Zhao Wei , Zhai Lili , Huo Peiyuan , Ren Lemin , Yu Lan , Li Yufeng
Published: August 2022

Ormutivimab is the first recombinant human anti-rabies monoclonal antibody (rhRIG) approved for clinical application in China. In this study, a population pharmacodynamic (PPD) model was established to compare the neutralizing antibody activities of Ormutivimab and human rabies immunoglobulin (HRIG), alone or combined with human rabies vaccine (Vero), in a phase II clinical trial, and to recommend a target dose for the phase III trial. The model was verified to fit the PPD data well. The stability of the model was verified by the bootstrap method. The level of neutralizing antibodies in vivo increased rapidly after administration of Ormutivimab or HRIG. Neutralizing antibodies with a strong activity were produced at 7 days (Ormutivimab + vaccine) or 10 days (HRIG + vaccine) after induction by the vaccine in vivo. Compared to that induced by HRIG + vaccine, the level of the neutralizing antibodies induced by Ormutivimab + vaccine peaked higher and faster. The levels of neutralizing antibodies induced by Ormutivimab + vaccine and HRIG + vaccine were similar within 21 days after administration. According to these results and the safety data, 20 IU·kg−1 was recommended as the target dose in the confirmatory study of Ormutivimab. Registration: ClinicalTrials.gov #NCT02559921.
COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects
Authors: Zarębska-Michaluk Dorota , Hu Chenlin , Brzdęk Michał , Flisiak Robert , Rzymski Piotr
Published: August 2022

In the light of the lack of authorized COVID-19 vaccines adapted to the Omicron variant lineage, the administration of the first and second booster dose is recommended. It remains important to monitor the efficacy of such an approach in order to inform future preventive strategies. The present paper summarizes the research progress on the effectiveness of the first and second booster doses of COVID-19. It also discusses the potential approach in vaccination strategies that could be undertaken to maintain high levels of protection during the waves of SARS-CoV-2 infections. Although this approach can be based, with some shortcomings, on the first-generation vaccines, other vaccination strategies should be explored, including developing multiple antigen-based (multivariant-adapted) booster doses with enhanced durability of immune protection, e.g., through optimization of the half-life of generated antibodies.
The Relative Positioning of B and T Cell Epitopes Drives Immunodominance
Authors: Biavasco Riccardo , De Giovanni Marco
Published: August 2022

Humoral immunity is crucial for protection against invading pathogens. Broadly neutralizing antibodies (bnAbs) provide sterilizing immunity by targeting conserved regions of viral variants and represent the goal of most vaccination approaches. While antibodies can be selected to bind virtually any region of a given antigen, the consistent induction of bnAbs in the context of influenza and HIV has represented a major roadblock. Many possible explanations have been considered; however, none of the arguments proposed to date seem to fully recapitulate the observed counter-selection for broadly protective antibodies. Antibodies can influence antigen presentation by enhancing the processing of CD4 epitopes adjacent to the binding region while suppressing the overlapping ones. We analyze the relative positioning of dominant B and T cell epitopes in published antigens that elicit strong and poor humoral responses. In strong immunogenic antigens, regions bound by immunodominant antibodies are frequently adjacent to CD4 epitopes, potentially boosting their presentation. Conversely, poorly immunogenic regions targeted by bnAbs in HIV and influenza overlap with clusters of dominant CD4 epitopes, potentially conferring an intrinsic disadvantage for bnAb-bearing B cells in germinal centers. Here, we propose the theory of immunodominance relativity, according to which the relative positioning of immunodominant B and CD4 epitopes within a given antigen drives immunodominance. Thus, we suggest that the relative positioning of B-T epitopes may be one additional mechanism that cooperates with other previously described processes to influence immunodominance. If demonstrated, this theory can improve the current understanding of immunodominance, provide a novel explanation for HIV and influenza escape from humoral responses, and pave the way for a new rational design of universal vaccines.
Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology
Authors: Bhoj Priyanka , Togre Namdev , Khatri Vishal , Goswami Kalyan
Published: August 2022

Human lymphatic filariae have evolved numerous immune evasion strategies to secure their long-term survival in a host. These strategies include regulation of pattern recognition receptors, mimicry with host glycans and immune molecules, manipulation of innate and adaptive immune cells, induction of apoptosis in effector immune cells, and neutralization of free radicals. This creates an anti-inflammatory and immunoregulatory milieu in the host: a modified Th2 immune response. Therefore, targeting filarial immunomodulators and manipulating the filariae-driven immune system against the filariae can be a potential therapeutic and prophylactic strategy. Filariae-derived immunosuppression can also be exploited to treat other inflammatory diseases and immunopathologic states of parasitic diseases, such as cerebral malaria, and to prevent leishmaniasis. This paper reviews immunomodulatory mechanisms acquired by these filariae for their own survival and their potential application in the development of novel therapeutic approaches against parasitic and inflammatory diseases. Insight into the intricate network of host immune-parasite interactions would aid in the development of effective immune-therapeutic options for both infectious and immune-pathological diseases.
Orthodontic Treatment of Dogs during the Developmental Stage: Repositioning of Mandibular Canine Teeth with Intercurrent Mandibular Distoclusion
Authors: Peruga Małgorzata , Piątkowski Grzegorz , Kotowicz Jakub , Lis Joanna
Published: August 2022

Linguoverted mandibular canines are relatively rare among craniofacial abnormalities, and they are an isolated anomaly. They are most often caused by non-genetic factors such as persistent deciduous canine teeth or trauma coinciding with the eruption of permanent teeth. Another factor may be mandible narrowing or underdevelopment in the transverse dimension and vestibular inclination of the maxillary canine teeth. This article presents a procedure based on three cases where the position of the mandibular canine tooth was corrected using human orthodontic appliances modified to affect the canine dental system. The incline of the appliance was made to stimulate the protrusion of the mandible while the teeth were closing. After approximately 4 weeks, the lower canine teeth moved along the incline of the appliance, and tilt toward the flews was achieved.
Removal of Pharmaceuticals in a Macrophyte Pond-Constructed Wetland System and the Effect of a Low Effluent Recirculation
Authors: Guedes-Alonso Rayco , Herrera-Melián José A. , Sánchez-Suárez Francisca , Díaz-Mendoza Verónica , Sosa-Ferrera Zoraida , Santana-Rodríguez José J.
Published: August 2022

Waste stabilization ponds and constructed wetlands (CWs) are effective at eliminating pharmaceutical residues, but removals are not usually complete. Their combination is regarded as an efficient, robust wastewater treatment method, but their efficiency in the removal of pharmaceuticals and the effect of a mild effluent recirculation has not been sufficiently studied in full-scale systems. Effluent recirculation can help to improve performance by increasing hydraulic residence time and, eventually, dissolved oxygen concentration. In this work, the presence of pharmaceuticals in wastewater from a university campus, their removal in a macrophyte pond–CW system, and the effect of effluent recirculation on removal and ecological risk were evaluated. Stimulants (caffeine and nicotine) and non-steroidal anti-inflammatories (naproxen and ibuprofen) were the most detected compounds in the influent and showed the highest concentrations, ranging from 0.5 to 300 µg·L−1. The pond–CW combination showed notable elimination for these compounds, achieving 87% on average. The ecological risk was also reduced by between 5.5 and 12.4 times, but it was still over values that indicates high ecological risk, mainly because of the concentrations of nicotine and ibuprofen. The effect of effluent recirculation was not as high as expected since the removals of caffeine, paraxanthine and naproxen were significantly improved, but those of atenolol and ibuprofen were lower. These results suggest that a higher recirculation ratio should be tested.
Conceptual Framework for Modeling Dynamic Complexities in Produced Water Management
Authors: Sabie Robert , Langarudi Saeed P. , Perez Kevin , Thomson Bruce , Fernald Alexander
Published: August 2022

This research addresses a gap in the produced water management (PWM) literature by providing a conceptual framework to describe the connections of PWM to regional water budgets. We use southeastern New Mexico as a case study, because the region is facing looming shortfalls in water availability, and oil and gas production generate high volumes of produced water in the region. The framework was developed through expert interviews, analysis of industry data, and information gained at industry meetings; it is supported by detailed descriptions of material flows, information flows, and PWM decisions. Produced water management decisions may be connected to regional water budgets through dynamic complexities; however, modeling efforts exploring PWM often do not capture this complexity. Instead, PWM is most often based on the least expensive management and disposal alternatives, without considering short and long-term impacts to the regional water budget. On the other hand, regional water budgets do not include treated produced water as a potential resource, thus missing opportunities for exploring the impact of potential beneficial reuse. This is particularly important when there is a need to address water shortages in chronically water-short regions of the United States. At the same time, oil and gas production in the western United States is challenged by the need to dispose of large volumes of produced water. The framework is useful for developing improved models of PWM to identify the impact of alternative management decisions on regional water budgets.
Visualization Assisted Approach to Anomaly and Attack Detection in Water Treatment Systems
Authors: Meleshko Alexey , Shulepov Anton , Desnitsky Vasily , Novikova Evgenia , Kotenko Igor
Published: August 2022

The specificity of the water treatment field, associated with water transmission, distribution and accounting, as well as the need to use automation and intelligent tools for various information solutions and security tools, have resulted in the development of integrated approaches and practical solutions regarding various aspects of the functioning of such systems. The research problem lies in the insecurity of water treatment systems and their susceptibility to malicious influences from the side of potential intruders trying to compromise the functioning. To obtain initial data needed for assessing the states of a water treatment system, the authors have developed a case study presenting a combination of a physical model and a software simulator. The methodology proposed in the article includes combining methods of machine learning and visual data analysis to improve the detection of attacks and anomalies in water treatment systems. The selection of the methods and tuning of their modes and parameters made it possible to build a mechanism for efficient detection of attacks in data from sensors with accuracy values above 0.95 for each class of attack and mixed data. In addition, Change_Measure metric parameters were selected to ensure the detection of attacks and anomalies by using visual data analysis. The combined method allows identifying points when the functioning of the system changes, which could be used as a trigger to start resource-intensive procedures of manual and/or machine-assisted checking of the system state on the basis of the available machine learning models that involve processing big data arrays.
Effects of Algae on the Formation of Black Blooms and Bacterial Community Structure Changes in Sediments and Black Floats
Authors: Tang Tingting , Ma Yingxiao , Shen Wendi , Li Zihao , Dai Ruihua , Ye Jianfeng
Published: August 2022

Black bloom is a phenomenon of serious deterioration in shallow-water ecosystems worldwide. This study investigated the effects of algae on the formation of black blooms and the changes of the bacterial community using nearly in-situ cores for a 40-day indoor simulation. We designed experiments with different combinations of water (W), sediments-water (SW), and sediments-water-algae (SWA), and made a comparative analysis of bacterial communities in sediments and black floats. The results demonstrated that the severity of black blooms was considerably affected by the presence of cyanobacteria. The concentration of total nitrates (TN) and NH4+-N in the SWA group increased to 25.1 and 22.47 mg/L (4.05 and 5.5 times of their initial concentrations), respectively. The abundance of microorganisms in the sediments was significantly higher than that of the black floats. The dominant species in both sediments were Proteobacteria and Chloroflexi, whose total proportion exceeded 50%. The addition of algae did not change the dominant community of the sediments. In black floats, the dominant species of the SW group were Proteobacteria (39%) and Actinobacteria (16%), and these of the SWA group were Proteobacteria (38%) and Cyanobacteria (35%). The dominant species in black floats changed significantly. Cyanobacteria increased remarkably in black floats in the group of algae additions. The possible reason may be that the Actinobacteria were suppressed by Cyanobacteria. Therefore, the addition of algae has a significant promoting effect on black blooms and significantly affects the microbial community structure of black floats.
Evaluating Impacts of Detailed Land Use and Management Inputs on the Accuracy and Resolution of SWAT Predictions in an Experimental Watershed
Authors: Qi Junyu , Kang Xiaoyu , Li Sheng , Meng Fanrui
Published: August 2022

Land use and management practice inputs to the Soil and Water Assessment Tool (SWAT) are critical for evaluating the impact of land use change and best management practices on soil erosion and water quality in watersheds. We developed an algorithm in this study to maximize the usage of land use and management records during the setup of SWAT for a small experimental watershed in New Brunswick, Canada. In the algorithm, hydrologic response units (HRUs) were delineated based on field boundaries and associated with long-term field records. The SWAT model was further calibrated and validated with respect to water flow and sediment and nutrient (nitrate and soluble phosphorus) loadings at the watershed outlet. As a comparison, a baseline version of SWAT was also set up using the conventional way of HRU delineation with limited information on land use and management practices. These two versions of SWAT were compared with respect to input and output resolution and prediction accuracy of monthly and annual water flow and sediment and nutrient loadings. Results show that the SWAT set up with the new method had much higher accuracies in generating annual areas of crops, fertilizer application, tillage operation, flow diversion terraces (FDT), and grassed waterways in the watershed. Compared with the SWAT set up with the conventional method, the SWAT set up with the new method improved the accuracy of predicting monthly sediment loading due to a better representation of FDT in the watershed, and it also successfully estimated the spatial impact of FDT on soil erosion across the watershed. However, there was no definite increase in simulation accuracy in monthly water flow and nutrient loadings with high spatial and temporal management inputs, though monthly nutrient loading simulations were sensitive to management configuration. The annual examination also showed comparable simulation accuracy on water flow and nutrient loadings between the two models. These results indicate that SWAT, although set up with limited land use and management information, is able to provide comparable simulations of water quantity and quality at the watershed outlet, as long as the estimated land use and management practice data can reasonably represent the average land use and management condition of the watershed over the target simulation period.
Potable Water Treatment in a Batch Reactor Benefited by Combined Filtration and Catalytic Ozonation
Authors: Ikhlaq Amir , Qazi Umair Yaqub , Akram Asia , Rizvi Osama Shaheen , Sultan Adeel , Javaid Rahat , Al-Sodani Khaled A. Alawi , Ibn Shamsah Sami M.
Published: August 2022

Due to continuous contamination of groundwater by anthropogenic activities, potable water fetches numerous pollutants such as pathogens, pharmaceuticals, and heavy metals, with these being severe health hazards. The main aim of the current study was to develop a hybrid unit based on catalytic ozonation and the filtration process to effectively remove the contaminants in drinking water. To the best of our knowledge, in the current study, the Fe-Zeolite 4A (Fe-Z4A)/O3 process followed by filtration involving rice husk and activated carbons were studied for the first time in order to treat drinking water. In the current investigation, fecal coliforms, arsenic, pharmaceuticals, turbidity, and TDS removal were investigated in a novel hybrid reactor. The results showed 100%, 45%, 40%, 70%, and 95% fecal coliform, arsenic, TDS, paracetamol, and turbidity removal efficiency, respectively. The results further indicated that all the studied drinking water samples followed WHO guidelines and NEQS for drinking water quality after the proposed treatment. Therefore, it is concluded that the proposed hybrid process implies a single unit is highly efficient for drinking water treatment. The designed novel hybrid reactor treatment can be scaled up in the future for household or commercial use.
Effects of the Digital Elevation Model and Hydrological Processing Algorithms on the Geomorphological Parameterization
Authors: Dávila-Hernández Sandra , González-Trinidad Julián , Júnez-Ferreira Hugo Enrique , Bautista-Capetillo Carlos Francisco , Morales de Ávila Heriberto , Cázares Escareño Juana , Ortiz-Letechipia Jennifer , Robles Rovelo Cruz Octavio , López-Baltazar Enrique A.
Published: August 2022

Hydrological cycle research requires a detailed analysis of the involved parameters to understand watershed behavior comprehensively. In recent decades, both Geographic Information Systems (GIS) and Digital Elevation Models (DEMs) were implemented and took a substantial role in watershed geomorphological parameterization; however, the variability of these instruments remains a challenge, together with high-resolution DEMs being unavailable, requiring digital processing to improve resolution. This research aims to merge DEMs and evaluate GIS geoprocessing algorithms to determine drainage networks and the geomorphological parametrization of a semiarid watershed. DEMs with resolutions of 1.5, 5, 12.5, and 30 m, the Jenson/Domingue (J/D) and Wang/Liu (W/L) fill algorithms; and D8, D, KRA, and MFD flow routing algorithms were used. One of the research findings proved that the divergences of the drainage networks are mainly attributed to filling algorithms and not flow routing algorithms; the shifts between the networks obtained in the processes reach horizontal distances up to 300 m. Since the water movement within the watershed depends on geomorphological characteristics, it is suggested that DEM-based hydrological studies specify both the resolution and the algorithms used in the parametrization to validate the rigidity of the research, improving estimate areas of high hydrological risk.
Trigeminal neuropathic pain in tumors of anterior and middle cranial base
Authors:   Federal State Autonomous Institution «N. N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian Federation, Yakimchuk V. N. , Kadasheva A. B. ,   Federal State Autonomous Institution «N. N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian Federation, Lasunin N. V. ,   Federal State Autonomous Institution «N. N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian Federation, Isagulyan E. D. ,   Federal State Autonomous Institution «N. N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian Federation, Aslakhanova K. S. ,   Federal State Autonomous Institution «N. N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian Federation
Published: August 2022

With cranial base neoplasms, the trigeminal nerve's function can often be disrupted, which is accompanied by both symptoms of insufficiency and irritation phenomena, including chronic neuropathic facial pain. In this situation, the problems of diagnosis and treatment are due to the complexity of the topographic structure of the mentioned anatomical region and various pathogenetic mechanisms for the development of pain syndrome. Thus, this issue is an interdisciplinary problem. A single approach to the treatment of such patients has not been developed yet. Material and methods. A selection of publications was made in the PubMed, Сochrane library and eLibrary systems using the following keywords: neuropathic facial pain, skull base tumors, trigeminal and cancer pain, facial pain and cancer/tumor, pain and depression, neuropathic facial pain, trigeminal neuropathy. Publications with a high degree of evidence were not found. 42 out of the 112 papers were selected as the most relevant. Results and discussion. Trigeminal neuropathic pain syndrome develops in about 5 % of patients with skull base tumors.Remaining after treatment (surgical or radiological), it dictates the need for the prescription of symptomatic therapy, taking into account the pathogenesis of the pathological process. The efficacy of drugs widely used for neuropathic pain in this category of patients has not been studied extensively. Conclusion. In the analyzed literature, it was not possible to find a unified approach to the management of such patients. As a rule, the authors offer well-established methods of conservative therapy used in the treatment of neuropathic facial pain as such, regardless of the mechanism of its occurrence. The question of the tactics of treating such pain caused by tumor lesions of the skull base remains unresolved.
Accounting of expenses and income from ordinary activities and their reflection in the reporting of agricultural organizations
Authors:   Federal State Budgetary Educational Institution of Higher Education «Stavropol State Agrarian University», Stavropol, Russia, Tunin S. A. , Frolov A. V. ,   Federal State Budgetary Educational Institution of Higher Education «Stavropol State Agrarian University», Stavropol, Russia, Khoruzhy V. I. ,   Federal State Budgetary Institution of Higher Education «Financial University under the Government of the Russian Federation», Moscow, Russia, Vorozheykina T. M. ,   Federal State Budgetary Institution of Higher Education «Russian Timiryazev State Agrarian University», Moscow, Russia
Published: August 2022

The article presents the results of the development and testing of methods for managing income and expenses from ordinary activities and their reflection in the reporting of agricultural organizations. The subject of the study is the accounting system for managing income and expenses, the object is the organization of the agro-industrial complex of the Stavropol Territory. Forms of specialized reporting of agricultural organizations of the Stavropol Territory served as the information base.
Reflection of the life cycle of an intangible asset in the accounting of a budgetary institution of the agro-industrial complex
Authors:   Stavropol State Agrarian University, Tunin S. A. , Frolov A.V. ,   Stavropol State Agrarian University, Khoruzhy V.I. ,   Financial University under the Government of the Russian Federation, Vorozheykina T.M. ,   Federal State Budgetary Educational Institution of Higher education “RGAU — MSHA named after K. A. Timiryazev”
Published: August 2022

The development of accounting in the public sector of the agro-industrial complex has significantly affected the accounting of intangible assets. With the application of the Standard, the approach to accounting for intangible assets has changed, now it is based on the principles of IFRS, therefore, intangible assets themselves can be presented from a different point of view. The authors of the article attempt to consider intangible assets as a life cycle model, which has not yet been applied to the concept of intangible assets. The algorithm of managerial decision-making and accounting of intangible assets at each stage of its life cycle is also proposed.
Analysis of the resource potential of digitalization in Russian agriculture
Authors:   Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Institute of Economics and Management of Agroindustrial Complex, Moscow, Russia, Kagirova M. V. , Demichev V. V. ,   Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Institute of Economics and Management of Agroindustrial Complex, Moscow, Russia, Tokarev V. S. ,   Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Institute of Economics and Management of Agroindustrial Complex, Moscow, Russia, Lebedev K. A. ,   Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Institute of Economics and Management of Agroindustrial Complex, Moscow, Russia
Published: August 2022

The paper is devoted to the study of the results and features of the process of import substitution in agriculture of the Russian Federation. Based on the use of time series analysis methods, calculation of structure indicators, comparison and differentiation indicators, trends were revealed towards an increase in the volume of production of main import-substituting products, a decrease in the share of imports in the resources of products, and an increase in the self-sufficiency ratio for a number of products. Particular attention is paid to the factors that limit the effectiveness of import substitution, such as the insufficient development of breeding and seed production in Russia, the high proportion of intermediate consumption of the cost of digital equipment and software of foreign production, insufficient funding from the government, the low level of income of producers and the unavailability of credit resources for implementation of the transition to modern production technologies in order to increase it on the basis of domestic resources.
Carencia de la investigación formativa en las universidades latinoamericanas en el periodo lectivo 2020 – 2021
Authors: Cornejo Bravo Daniela , Paucar Córdova Rosman , Córdova Aguilar Jhonny , De La Cruz Lozado Juan
Published: August 2022

La formación de competencias científicas permite manifestar conflictos societales que implican al hallazgo de nuevos conocimientos, evidenciando la necesidad de instruir al ser humano partiendo desde un enfoque científico y humanístico. Bajo esta premisa, persigue realizar una revisión sistemática de la carencia de la formación de competencias científicas en estudiantes por las universidades latinoamericanas, periodo lectivo 2020 – 2021. La metodología empleada fue de alcance descriptivo–explicativo, enfoque cualitativo; que consistió en una sistematización de una base de datos consultados como Scopus, Scielo, Dialnet, Journal, Delectus; extrayendo aportaciones del 2018 al 2021, incluyendo 50 artículos de revisión y solo 12 evidencias seleccionadas. Concluyendo que las universidades carecen de procesos de formación investigativa; sin embargo, existe una preocupación para gestionar y darle la importancia a las competencias científicas en estudiantes, crear una cultura investigativa en la gestión de enseñanza y aprendizaje e incentivar la construcción de nuevos saberes a partir del análisis social.
Aspectos neurológicos do SARS-COV-2 e os desafios e perspectivas da fisioterapia: revisão de literatura
Authors: Marques Nayara , Matias Júnior Ivair
Published: August 2022

Introdução. O SARS-CoV 2 vem sendo associado às manifestações neurológicas e a reabilitação física nesses tempos, desempenha um papel importante no atendimento destes pacientes em estado crítico até à alta hospitalar, visando a recuperação funcional após a fase aguda da doença. Objetivo. Investigar os aspectos neurológicos decorrentes do COVID-19 e descrever os desafios e perspectivas da fisioterapia neurofuncional na melhora da qualidade de vida destes indivíduos. Método. Foi realizando um levantamento bibliográfico em base de dados confiáveis como PubMed, SciELO, Science Direct, PMC e plataforma PEDro. Resultados. Foram selecionados 12 trabalhos de ensaios clínicos. Os autores relatam que os eventos tromboembólicos são considerados como maior preditor de óbito, sendo o AVCi o mais acometido, assim como que as manifestações neurológicas ocorreram no início da doença. A fisioterapia demonstra que o tempo de permanência foi um preditor significativo de melhora na força muscular e no estado funcional, quando comparado ao tempo total de internação. Conclusão. As manifestações neurológicas associadas ao COVID-19 tiveram um grande impacto na saúde pública e que compete aos fisioterapeutas neurofuncionais promover qualidade de vida, devolvendo a funcionalidade para estes indivíduos.
Diversión y funciones simbólicas de los enanos y jorobados en la sociedad mexica
Authors: Mazzetto Elena
Published: August 2022

Este artículo propone un acercamiento a las funciones desempeñadas por enanos y jorobados en la sociedad mexica y, en particular, en la vida palaciega del soberano. En primer lugar, el trabajo pretende estudiar estos personajes a través de sus papeles cotidianos, como emisarios y confidentes del tlatoani. Sucesivamente, el estudio se centrará en las actividades de entretenimiento puestas en escena por estos individuos, mismas que abarcaban desde la música y danza hasta la acrobacia. Otro tema que se analizará será el sacrificio de enanos y jorobados para acompañar al soberano difunto en el más allá y en caso de sequía o eclipse solar. A través de la información rastreada en las fuentes documentales del siglo XVI, el artículo proporciona nuevas pistas interpretativas para comprender la importancia de estos personajes en la sociedad nahua prehispánica.
¿Quiénes son los trigueños? Análisis de una categoría racial intersticial (1810-1830).
Authors: Guzmán Florencia
Published: August 2022

El término trigueño es una categoría intersticial y ambigua con la que fue clasificado un importante porcentaje de soldados y reclutas de condición libre a partir de 1810. Esta investigación tiene un doble propósito. Por un lado, examinar el contenido histórico de la expresión trigueño a través de las fichas de filiación relativas a los reclutas militarizados entre 1810-1830, articulando la dimensión racial con otras variables como la procedencia, el modo de vida y la instrucción; por el otro, enfatizar la posibilidad mestiza que asume esta expresión, pues matiza la idea del traslado estadístico de la población africana a esta categoría y remite invariablemente al estudio del mestizaje colonial y de las categorías raciales de la hibridez. El dialogo entre corpus documentales del temprano republicanismo posibilita una mayor comprensión de las lógicas de clasificación en tanto éstas revelan -o son indicios de- las políticas que crearon esos instrumentos y también quienes las produjeron.
"Los que caminan". Un acontecimiento narrativo calchaquí valorado desde la arqueología y la etnohistoria
Authors: De Hoyos María
Published: August 2022

El arte rupestre Tardío registrado en la cueva Quillivil, ubicada en los Valles Calchaquíes, en el Noroeste argentino, exhibe una serie de hileras de figuras humanas pintadas, caminando en una u otra dirección. Estas figuras lucen atuendos decorados e importantes tocados cefálicos sugiriendo que se trata de personajes de elite ¿Quiénes son estos personajes y cuál era su destino? Para intentar responder a estas preguntas adopté, como metodología, una perspectiva narrativa que tiene como fundamento el transcurrir de actores a través de diferentes soportes; es decir, identificar romerías similares en otros sitios con arte o en piezas arqueológicas de la región. Estos cambios de escenario van conformando el hilo de una narración y las comparaciones facilitan la identificación de los atavíos y objetos presentes en las pinturas. Esta información sumada a la proveniente de fuentes etnohistóricas andinas -locales y regionales- permite formular hipótesis acerca del acontecimiento que se está escenificando.
Una propuesta teórico-metodológica en el devenir territorial. Pulmarí y sus rizomas
Authors: Papazian Alexis
Published: August 2022

Este artículo repone parte de los estudios y viajes de campo realizados en la región de Pulmarí -departamento de Aluminé, provincia del Neuquén, Argentina- entre 2007 y 2017. A partir del trabajo de campo, el relevamiento de diferentes archivos y los aportes generados desde la geografía y la cartografíacrítica, se propone una forma de comprensión territorial que observa los intersticios y los vaso-comunicantes entre lógicas que, en principio, se presentan paralelas y sin conexión posible. Este tipo de acercamiento al territorio requiere cruzar el espacio con el tiempo, generando una profundidad histórica que permita explicar las agencias y las reemergencias particulares de cada territorio. Asimismo, proponemos conexiones con “el afuera” que tensiona y pliega el territorio. Al igual que un río, el territorio está en constante movimiento, pero esos movimientos son capas, de ahí la importancia de incluir estos pasados-presentes en las formas de ser en el territorio.
No hay dacalapata (carne), no hay reducción. La fuga de los indios de San Ignacio de los Tobas a comienzos del siglo XIX
Authors: Cutrera María Laura
Published: August 2022

El trabajo toma como punto de partida un artículo de Martha Bechis en que se utiliza la teoría matemática del drama o teoría de la confrontación. Se recurre a ella en tanto herramienta metodológica que permite entender un episodio histórico cuyos sentidos profundos se encuentran en un proceso más amplio, dentro del que se cargan de significados y relaciones. Analizamos la fuga de los tobas de la reducción de San Ignacio jurisdicción de Jujuy- a comienzos del siglo XIX. Para ello, ubicamos el episodio dentro del drama de la crónicainestabilidad fronteriza y la escasez de recursos destinados al mantenimiento de fuertes y reducciones, y lo cruzamos con episodios del mismo drama y de otro -la suspensión de las raciones al pueblo, la explotación indígena en las haciendas y las malas conductas del fray Ortiz. Proponemos que la fuga era una estrategia a la que los indígenas recurrían para hacer valer sus intereses y necesidades frente a los hispanocriollos.
Reseñas de: Catálogos del Fondo “Tribunales de Justicia”, Escribanía I (1574-1616) y (1624-1655). Archivo Histórico de la Provincia de Córdoba (República Argentina). Córdoba, Centro de Estudios Históricos “Prof. Carlos S. A. Segreti” (2019 y 2021)
Authors: Boixados Roxana
Published: August 2022

Las ediciones digitales -en 2019 y 2021- de estos dos catálogos elaborados sobre los Fondos Tribunales de Justicia de la Escribanía 1, uno de los acervos coloniales más importantes que custodia el Archivo Histórico de la Provincia de Córdoba (AHPC), comprenden las fichas elaboradas sobre la base de descriptores multinivel sobre un conjunto de expedientes judiciales (1574-1616 y 1624-1655), realizado por un equipo intediciplinario de especialistas bajo la dirección de C. González Navarro (el primer volumen) y de C. González navarro y R. Grana (el segundo volumen).
¿Sepulturas de charrúas en la Sierra del Arbolito? Aproximación desde la Historia y la Arqueología a partir de un plano de 1834 que las señala en la República Oriental del Uruguay
Authors: Bracco Diego , L´ópez Mazz Jos´é M.
Published: August 2022

A partir de un plano de 1834 indicando la ubicación de sepulturas de charrúas se procedió a una investigación interdisciplinaria histórico-arqueológica. La información se consideró excepcional debido a que no se conocen otras fuentes que indiquen con precisión sitios de esa naturaleza referidos a la nación charrúa.También se consideró relevante la escasa distancia entre el sitio y aquellos lugares en donde sucedieron los hechos que pusieron fin a la presencia de la nación charrúa en la naciente República Oriental del Uruguay. También se tomó en cuenta el breve lapso transcurrido entre aquellos hechos y la confección del plano -1831 y 1834 respectivamente. Los principales resultados de la investigación fueron la ubicación del sitio sobre el terreno, el reconocimiento inicial de sus características, así como la identificación de patrones y regularidades en el entorno. Además se buscaron similitudes entre el sitio, su contexto y las fuentes etnohistóricas disponibles.
Espacios y actividades cotidianas de la infancia nahua prehispánica
Authors: Díaz Barriga Cuevas Alejandro
Published: August 2022

En el presente artículo se analizan los diferentes espacios donde transcurría la vida cotidiana de niñas y niños nahuas del Altiplano Central mesoamericano, a partir de fuentes documentales. Se inicia con el análisis de la vida cotidiana en las casas y las unidades domésticas. Posteriormente, se estudia su presencia en lugares como el mercado, la milpa, el monte y la laguna, sitios en donde mediante su participación en las labores económicas, iban aprendiendo las actividades que tendrían que desempeñar en su vida adulta. De igual forma, se presenta brevemente su paso por los templos de educación; y finalmente se proponen otros lugares en donde se desenvolvía la niñez prehispánica.
Innovaciones industriales tempranas, empresarios, mujeres letradas y comerciantes mapuche en la frontera de Concepción y la Araucanía. El Correo del Sur 1849-1865
Authors: Inostroza Córdoba Luis Iván , González Gómez Yéssica , Del Valle Rojas Carlos
Published: August 2022

Este artículo emplea el registro del periódico El Correo del Sur, publicado en la ciudad de Concepción -situada al sur del naciente Estado de Chile- entre 1849 y 1865, para examinar las percepciones acerca del cambio histórico desencadenado por las innovaciones de la revolución industrial, vinculadas con la instalación de fábricas molineras, el desarrollo de la minería del carbón de piedra, el uso de motores a vapor y la edición de periódicos. Particularmente, lo hace desde la óptica del surgimiento de nuevos agentes sociales como empresarios, mujeres letradas de la elite y obreros asalariados, a los que se suman actores tradicionales como los comerciantes mapuches de la frontera de la Araucanía que se mantenían al margen del Estado republicano. Estas figuras son relevadas en el periódico como personajes que articulan la transición haciauna economía de mercado global.
Reseña de: Flechas invisibles. La agresión mágica entre las sociedades indígenas de la Araucanía, Pampas y Norpatagonia (siglos XVI-XIX), de Joaquín García Insausti (2021). Rosario, Prohistoria.
Authors: Rodriguez Lauro Ezequiel
Published: August 2022

Este trabajo de García Insausti, doctor en Historia por la Universidad Nacional del Sur (Bahía Blanca, Buenos Aires, Argentina), nos propone a lo largo de nueve capítulos introducirnos en el estudio de una temática que aborda parte de la cosmovisión de las antiguas sociedades indígenas de la región Araucanía, Pampas y Norpatagonia y que ha sido poco estudiada hasta el momento. El autor centra su investigación en torno a las creencias sobre la agresión mágica, o kalkatun, que existía entre estas poblaciones. A partir de un diverso conjunto de fuentes registradas entre los siglos XVI y XIX, analiza en profundidad tanto las creencias como las dinámicas sociales relacionadas con esta práctica mágica.
Reseña de: El país indiviso, de Roxana Boixadós y Judith Farberman (2021). Ciudad Autónoma de Buenos Aires, Prometeo Libros
Authors: Larreburo Mario Emanuel
Published: August 2022

El libro tiene como objetivo estudiar la configuración de la región de Los Llanos -actual Argentina- durante el largo siglo XVIII, analizando sus dinámicas geográficas y sociales y los conflictos en torno a las tierras; es un importante aporte para el campo de los estudios histórico antropológicos de de dicha región pues da cuenta de las condiciones de formación y las transformaciones de los campos comunes o estancias indivisas durante el siglo XVIII.  El análisis de los pleitos por tierras permitió a las autoras dar cuenta de  la propiedad indivisa, funcional a la actividad ganadera ya que evitaba la fragmentación de las estancias.