bluuebunny/crossref_metadata_2025 huggingface dataset:
Geriatric assessment and management with question prompt list using a web-based application for elderly patients with cancer (MAPLE) to communicate ageing-related concerns: J-SUPPORT 2101 study protocol for a multicentre, parallel group, randomised controlled trial
Authors: Matsuoka Ayumu , Fujimori Maiko , Narikazu Boku , Takashima Atsuo , Okusaka Takuji , Mori Keita , Akechi Tatsuo , Shimazu Taichi , Okizaki Ayumi , Miyaji Tempei , Majima Yoshiyuki , Nagashima Fumio , Uchitomi Yosuke
Published: September 2022

Introduction

Elderly cancer patients often have ageing-related physical and psychosocial problems that should be fully shared with their oncologists. Geriatric assessment (GA) can assess these ageing-related problems and guide management. Communication support might also facilitate implementation of GA-guided management. We will conduct a multicentre, randomised controlled trial to examine the efficacy of a programme that combines a GA summary, management recommendations and communication support to facilitate ageing-related communications between elderly Japanese patients with cancer and their oncologists, and thus to implement programme-guided management.

Methods and analysis

We plan to recruit a total of 210 patients aged ≥70 years, diagnosed with incurable cancers of gastrointestinal origin, and referred for first-line or second-line chemotherapy. In the intervention arm, a summary of management recommendations based on a GA and question prompt list (QPL) will be provided to patients and shared with their oncologists at the first outpatient visit after randomisation by trained intervention providers. For 5 months after the initial intervention, implementation of GA-guided management recommendations will be reviewed monthly with the patients and their oncologists to implement management as needed. The GA and QPL will be re-evaluated at 3 months, with a summary provided to patients and their oncologists. Those participants allocated to the usual care arm will receive usual oncology care. The primary endpoint is the number of conversations about ageing-related concerns at the first outpatient visit after randomisation.

Ethics and dissemination

This study was approved by the institutional review board of the National Cancer Center Japan on 15 April 2021 (ID: 2020–592). Study findings will be disseminated through peer-reviewed journals and conference presentations.

Trial registration number

UMIN000045428.
Pregnancy outcomes in women with gestational diabetes mellitus by models of care: a retrospective cohort study
Authors: Harrison Jackson , Melov Sarah , Kirby Adrienne C , Athayde Neil , Boghossian Araz , Cheung Wah , Inglis Emma , Maravar Kavita , Padmanabhan Suja , Luig Melissa , Hook Monica , Pasupathy Dharmintra
Published: September 2022

Objective

To compare birth outcomes of women with gestational diabetes mellitus (GDM) with background obstetric population, stratified by models of care.

Design

Retrospective cohort study.

Setting

A tertiary referral centre in Sydney, Australia.

Participants

All births 1 January 2018 to 30 November 2020. Births <24 weeks, multiple gestations and women with pre-existing diabetes were excluded.

Methods

Data were obtained from electronic medical records. Women were classified according to GDM status and last clinic attended prior to delivery. Model of care included attendance at dedicated GDM obstetric clinics, and routine antenatal care.

Main outcome measures

Hypertensive disorders of pregnancy (HDP), pre-term birth (PTB), induction of labour (IOL), operative delivery, small for gestational age (SGA), large for gestational age, postpartum haemorrhage, obstetric anal sphincter injury (OASIS), neonatal hypoglycaemia, neonatal hypothermia, neonatal respiratory distress, neonatal intensive care unit (NICU) admission.

Results

The GDM rate was 16.3%, with 34.0% of women managed in dedicated GDM clinics. Women with GDM had higher rates of several adverse outcomes. Only women with GDM attending non-dedicated clinics had increased odds of HDP (adjusted OR (adj OR) 1.6, 95% CI 1.2 to 2.0), PTB (adj OR 1.7, 95% CI 1.4 to 2.0), OASIS (adj OR 1.4, 95% CI 1.0 to 2.0), similar odds of induction (adj OR 1.0, 95% CI 0.9 to 1.1) compared with non-GDM women. There were increased odds of NICU admission (adj OR 1.5, 95% CI 1.3 to 1.8) similar to women attending high-risk GDM clinics.

Conclusions

Women with GDM receiving care in lower risk clinics had similar or higher rates of adverse outcomes. Pathways of care need to be similar in all women with GDM.
Clinical utility of anti-interleukin 5 monoclonal therapy in asthma using a national, centralised, outcome-based system of drug access
Authors: O'Leary Caroline , Schultz Christopher , Walsh Cathal , Adams Roisin , Casey Deborah , Lane Stephen , Harrison Michael , Doyle Shane , Costello Richard W , King Fionnuala , Murphy Desmond M
Published: September 2022

Introduction

Interleukin 5 (IL-5) inhibitors are an important therapeutic advance in the management of severe, refractory, eosinophilic asthma. However, their utilisation should be targeted to maximise their benefits. This study used multisite, centralised, national data collected over 18 months to perform an observational integrated, retrospective, cohort study of selection criteria for initiation and continuation of IL-5 inhibitor treatment in Ireland.

Materials/patients and methods

We used data from 230 patients who were given anti-IL-5 monoclonal therapy (reslizumab, mepolizumab or benralizumab) in Ireland between 2018 and 2020. Reimbursement of these drugs in Ireland requires fulfilling eligibility criteria defined by the Acute Hospitals Drugs Management Programme with continued reimbursement requiring ongoing submission of clinical data demonstrating clinical effectiveness.

Results

IL-5 inhibitor use for 18 months was associated with a total reduction in asthma-associated hospital admissions of 108 (p=0.036) and in non-hospital exacerbations of 85 in 18 months (p=0.014). Respiratory-associated GP visits were reduced from 637 in 12 months to 89 at 6 months and 210 at 18 months of treatment (p<0.001). Oral corticosteroid requirement was reduced or stopped entirely (p<0.001). Subgroup analysis of one site replicated these results and showed a significant reduction in the Asthma Control Questionnaire Score (p<0.001)

Conclusions

Selected patients continued on IL-5 treatment to 18 months had significantly reduced exacerbations, GP visits, oral corticosteroid use and asthma-associated hospitalisations. These results show that anti-IL-5 therapy, in carefully selected and monitored patients with asthma, results in significant improvements in clinical outcomes in a real-world setting.
Nonlinear dynamics of a liquid film flow over a solid substrate in the presence of external shear stress and electric field
Authors: Zakaria Kadry , Sirwah Magdy A.
Published: September 2022

Using approximation techniques, long-wave length framework and boundary-layer, the effects of electrostatic force and induced shear stress on the flow behavior down an inclined solid substrate are investigated. In general case, the considered model accounts in the presence of inertia regime and streamwise viscous diffusion with the influence of normal electric field and an imposed shear stress. Using the Galerkin weighted residual, two coupled evolution equations for the flow rate and film thickness are extracted. In the appropriate limit cases, the evolution equations obtained by previous authors are recovered. The primary instability has been analyzed using the Whitham wave hierarchy framework. In the nonlinear regime, the behavior of solitary waves arose on the surface of liquid film due to the effects of electrostatic force and imposed shear stress throughout three-dimensional dynamical systems. Some bifurcation points are reported. In both extremely viscous and electrogravity regimes, the Benney-like equation is extracted in a new form. By excluding contribution of external shear stress and viscous dispersion parameter, the interesting results of previous authors are recovered. In both weakly nonlinear and inertialess regimes, the bifurcation points of the three dynamical systems are discussed within the Kuramoto–Sivashinsky type equation.
Fully heavy hexaquark states via the QCD sum rules
Authors: Wang Zhi-Gang
Published: September 2022

In this paper, we construct the diquark–diquark–diquark-type vector six-quark currents to investigate the vector and scalar hexaquark states in the framework of the QCD sum rules in a consistent way, and make predictions for the hexaquark masses. We can search for the fully heavy hexaquark states in the di-[Formula: see text] and di-[Formula: see text] invariant mass spectra in the future. Combined with our previous works on the fully heavy tetraquark states and pentaquark states, the present predictions can shed light on the nature of the fully heavy multiquark states.
Resolving an ambiguity of Higgs couplings in the FSM, greatly improving thereby the model’s predictive range and prospects
Authors: Bordes José , Chan Hong-Mo , Tsou Sheung Tsun
Published: September 2022

We show that, after resolving what was thought to be an ambiguity in the Higgs coupling, the FSM gives, apart from two extra terms (i) and (ii) to be specified below, an effective action in the standard sector which has the same form as the SM action, the two differing only in the values of the mass and mixing parameters of quarks and leptons which the SM takes as Γinputs from experiment while the FSM obtains as a result of a fit with a few parameters. Hence, to the accuracy that these two sets of parameters agree in value, and they do to a good extent as shown in earlier work, 1 the FSM should give the same result as the SM in all the circumstances where the latter has been successfully applied, except for the noted modifications due to (i) and (ii). If so, it would be a big step forward for the FSM. The correction terms are: (i) a mixing between the SM’s [Formula: see text] with a new vector boson in the hidden sector, (ii) a mixing between the standard Higgs with a new scalar boson also in the hidden sector. And these have been shown a few years back to lead to (i[Formula: see text]) an enhancement of the W mass over the SM value, 2 and (ii[Formula: see text]) effects consistent with the [Formula: see text] and some other anomalies, 3 precisely the two deviations from the SM reported by experiments 4 , 5 recently much in the news.
Noncommutative (2+1)-dimensional Anandan effects
Authors: Jing Jian , Wang Ya-Li , Wang Qing , Kong Ling-Bao , Dong Shi-Hai
Published: September 2022

By identifying the model of a relativistic spin-half neutral particle which possesses magnetic and electric dipole moments interacting with an electromagnetic field as the [Formula: see text] gauge theory, we study the Anandan phase in [Formula: see text]-dimensional noncommutative space–time by applying the Seiberg–Witten map. We find that up to the first order of the noncommutative parameter, Anandan phase does not receive any corrections due to the spatial noncommutativity. Our result also indicates that phases of either Aharonov–Casher or He–Mckellar–Wilkens effects can receive corrections due to spatial noncommutativity.
Travelling Route Recommendation Method Based on Graph Neural Network for Improving Travel Experience
Authors: Wang Lang
Published: September 2022

With the rapid development of Internet technology, people can learn all kinds of travel information anytime and anywhere. However, the serious information overload causes travelers to be unable to make accurate and reasonable travel routes that meet tourists’ tastes for a while, thus reducing the quality of travel. The recommendation system as the mainstream solution to the information explosion of two means has received the attention of the majority of scholars and industry. Based on the research theory of tourist route recommendation, this paper analyzes the characteristics of attractions, factors affecting travelers’ travel experience when touring attractions and factors affecting travelers’ travel experience along tourist routes. Furthermore, we propose a tourist route recommendation model that meets tourists’ preferences. Then, this paper uses the graph neural network (GNN) algorithm to build a framework for tourist route recommendations based on the GNN using the relationship of preference and commonality existing among groups, tourists and attractions. The GNN algorithm is optimized and improved using multiple graphs and an attention mechanism. Finally, the effectiveness of this paper’s algorithm is verified by conducting experiments on different data sets.
Financial Time Series Forecasting: A Combinatorial Forecasting Model Based on STOA Optimizing VMD
Authors: Yao Tianxiang , Liu Xichun
Published: September 2022

The complexity and frequent fluctuations of economic data pose a significant challenge to forecasting studies. In order to predict financial data more accurately, we build a fusion model for predicting financial data based on the idea of decomposition-recombination by combining the Sooty Tern Optimization Algorithm (STOA), Variational Mode Decomposition (VMD), Support Vector Machine (SVM) and Back Propagation Neural Network (BPNN). Firstly, after finding the optimal parameters of the VMD by the STOA, adjust the parameters of the VMD and decompose the financial data, remove the residual from the series, and constitute the remaining necessary information within the financial data into new series modeled by applying the SVM. Finally, calculate the error between the predicted and actual values. Notably, the residual is treated specially in the modeling. A Double-layer BPNN model is used to establish a mechanism to increase the sensitivity of the model fluctuations. The influence factor series and the residual are introduced as input variables to the BPNN to establish a mapping relationship between them and the error series. The results show that the model improves data utilization through five experiments, solves the problem of the VMD insensitivity to fluctuations, and improves the prediction accuracy of financial time series effectively.
A FINITE ELEMENT ANALYSIS OF SEMI-RIGID SINGLE AND TWO LEVEL PEDICLE SCREW-ROD FIXATION IN LUMBAR SPINE
Authors: BISWAS JAYANTA KUMAR , MALAS ANINDYA , RANA MASUD
Published: September 2022

For the treatment of degenerative disc disease (DDD) and associated back pain and instability in the spinal segments, the success of pedicle screw-based spinal implant system has been found in the literature. Over the last couple of years, various nonfusion implants are made for the treatment of minor DDD. In this study, the biomechanical response of pedicle screw-based implant with semi-rigid rod material on the lumbar spine is evaluated. Computed tomography (CT) scan-based finite element (FE) model is used to evaluate the performance of pedicle screw fixation with flexible rods made of carbon fiber-reinforced polyetheretherketone (CFR PEEK). Typical physiological loadings are applied to the intact and implanted lumbar spine model. It is observed that the pediclescrew with the CFR-PEEK rod can restore the range of motion (ROM) on the surgical segment. The CFR-PEEK RODs carried out more loads and reduced the stress on the vertebral body. Using traditional rigid rods, ROM is generally almost restricted on the fusion zone, which can be improved by CFR-PEEK rod system to a certain degree. After successful experimental validation and clinical trial, the CFR-PEEK rod may be recommended for improved clinical outcomes.
NONINVASIVE DETERMINATION OF PROPAGATION PARAMETERS IN THE CAROTID ARTERY
Authors: AYADI ASMA , SAHTOUT WASSILA , BALEDENT OLIVIER
Published: September 2022

Few studies are interested in the noninvasive determination of propagation parameters. Reflected waves can be used as an intelligent tool for therapeutic measures. The amplitude and arrival time of reflected wave play an interesting role in investigating cardiovascular diseases. Therefore, this study aims to implement a method based on cepstral analysis for noninvasive decomposition of the incident and reflected waves and determination of local propagation parameters. The cepstral analysis is applied to the blood velocity, which is measured by using phase-contrast magnetic resonance imaging (PCMR) in 20 subjects. The determination of propagation parameters: arrival time, attenuation coefficient, reflection amplitude, and reflection coefficient is based on a mathematical model developed in the previous work. To evaluate the precision of the proposed approach, we focused on the effect of age. In addition, we intended to compare the obtained results to those obtained by the wave intensity analysis (WIA) method. A statistical test analysis was conducted to establish the relationship between the propagation parameters and the age. Our experimental results showed that there is no significant difference in terms of propagation parameters with age ([Formula: see text]). Our experimental results correlated with reference values reported in previous studies conducted on the internal arterial carotid. The propagate parameters obtained by the proposed method varied slightly with age. Moreover, the reflection coefficient detected using our proposed method was close to that detected using WIA. We can conclude that the technique described in this paper offers a promising and efficient approach to separating measured velocity waveforms into their incident and reflected components noninvasively.
Transmission dynamics of Hand–Foot–Mouth Disease with partial immunity through non-integer derivative
Authors: Jan Rashid , Boulaaras Salah , Alyobi Sultan , Jawad Muhammad
Published: September 2022

In this paper, we formulate the transmission phenomena of Hand–Foot–Mouth Disease (HFMD) through non-integer derivative. We interrogate the biological meaningful results of the recommended system of HFMD. The basic reproduction number is determined through next generation method and the impact of different parameters on the reproduction number is examined with the help of partial rank correlation coefficient (PRCC) technique. In addition, we concentrated on qualitative analysis and dynamical behavior of HFMD dynamics. Banach’s and Schaefer’s fixed-point theorems are used to analyze the uniqueness and existence of the solution of the proposed HFMD model. The HFMD system’s Ulam–Hyers stability has been confirmed to be sufficient. To highlight the impact of the parameters on the dynamics of HFMD, we performed several simulations through numerical scheme to conceptualize the transmission route of the infection. To be more specific, numerical simulations are used to visualize the effect of input parameters on the systems dynamics. We have shown the key input parameters of the system for the control of infection in the society.
A computational micromechanical approach to predicting Young’s modulus of continuous banana and palmyra fiber-reinforced epoxy composites
Authors: Bhaskar Vennapusa Vijaya , Srinivas Kolla , Devireddy S. B. R.
Published: September 2022

The prediction of Young’s modulus properties of a hybrid composite using micromechanical models based on the geometrical characteristics and individual constituent properties of materials is a challenging task for the researchers. In this work, the micromechanical and experimental approaches are used to evaluate the hybrid effect on the Young’s modulus properties of continuous banana and palmyra fiber-reinforced epoxy composites. In computational modeling, a square unit cell is employed by using ANSYS to study the effect of the fiber weight percentage and weight ratio over Young’s modulus properties along the longitudinal and transverse direction. The effectiveness of the numerical predictions is evaluated by comparing with the experimental results and analytical micromechanical models (Rule of hybrid Mixture, Halpin–Tsai (HT), and Lewis and Nielsen). In the experimental approach, the hybrid composites were fabricated with the continuous banana and palmyra fibers reinforced with epoxy by varying the fiber percentages (10%, 20%, 30% and 40%) and weight ratios (1:1, 1:3, and 3:1). The micromechanical approaches show that Young’s modulus of the hybrid composites is consistently increased with the fiber percentages. The longitudinal Young’s modulus obtained by the Lewis and Nielsen equation gave good agreement with numerical and experimental results. On the other hand, the experimental transverse Young’s modulus gave a better fit with the inverse rule of hybrid mixture as compared with other analytical model predictions.
Numerical simulation of shear behaviour of echelon rock joint using localising gradient damage model
Authors: Rajput Anshuman , Shedbale Amit Subhash , Khan Debashis
Published: September 2022

In this work, the crack growth behaviour in rock joints under shear load is investigated using the localised gradient damage model (LGDM). The LGDM is shown to capture the mixed-mode fracture phenomena with mesh-independent structural response and sharp localising crack profiles using a simple isotropic scalar damage variable. A simplified staggered scheme based on an operator-split approach is adopted for numerical analyses. The shear box experiments are considered to demonstrate the predictive capabilities of the proposed scheme. Two different crack joint configurations i.e., non-overlapping and overlapping are numerically simulated and the results in terms of crack profiles and structural responses are compared with the experimental results. It is observed that the non-overlapping crack joints fail in mixed-mode whereas overlapping crack joints fail in tensile mode. Further, the non-overlapping crack joints show higher shear load capacity as compared to overlapping crack joints.
A Statistical Design Approach on Electrochemical Impedance Spectroscopy of NMC Li-Ion Battery
Authors: Erol Salim
Published: September 2022

Robust development of energy storage materials requires a deep understanding of the relationship between the operation conditions and electrochemical properties. The influences of cell potential and environmental temperature on battery dynamics of commercially available LiNiMnCoO2(NMC)/graphite(C) coin cells were statistically investigated and discussed by using electrochemical impedance spectroscopy measurements and Taguchi statistical design. The Taguchi method reduced the variation in the electrochemical process with an experimental design; therefore, number and duration of impedance measurements were minimized. This design tested three levels for each categorical factor that are the cell potential and the cell temperature. The third level of both potential and temperature optimized the dynamic parameters of the batteries. The calculated signal-to-noise ratio and delta values for the cell temperature were higher for each battery resistance than that of the cell potential. In addition, the calculated probability, P value, was also lower (around zero) for the cell temperature. Thus, the temperature was determined to be the most significant factor, suggesting that this factor should be constrained carefully when the battery dynamics is desired to be optimized. In this paper, the electrochemical impedance spectroscopy method combined with the Taguchi design was performed to offer an unprecedented insight into the effects of the factors on the elements of the equivalent circuit model of the Li-ion coin cells.
A Novel Chronoimpedimetric Cytosine Modified Molecularly Imprinted Sensor for Label-Free Detection of 8-Hydroxydeoxyguanosine in Urine Samples
Authors: Ertugrul Uygun Hilmiye Deniz , Uygun Zihni Onur , Girgin Sagin Ferhan
Published: September 2022

First time in the literature, we imprinted 8-hydroxyguanosine (8OHG) to engineer an impedimetric sensor on a polymer from three different main non-covalent structures. Considering the chemical structure of the molecule and its potential non-covalent bonding behaviors, we designed a special electrode with molecular imprinting technology (MIT). Therefore, 8OHG, which serves as an important biomarker of oxidative stress, was imprinted on an electrode to form an 8OHG sensor. In this imprinting method, firstly, a gold electrode was modified with Cytosine-1yl-acetic acid (CAA) to increase selectivity and form DNA hydrogen bond-like structures. Afterward, pyrrole and aminophenyl boronic acid monomers were polymerized from three different points by electropolymerization, and a selective and sensitive sensor technology was developed. 8OHG measurement was carried out impedimetrically in six minutes (R2 value in the range of 500–10000 pg ml−1 is 0.9928 ± 0.006). LOD and LOQ was calculated 155.8 pg ml−1 and 472 pg ml−1, respectively. In conclusion, a sensitive, low-cost, fast and innovative technique with higher selectivity has been introduced. We believe that novel imprinting techniques will provide the important potential for MIP techniques for medical diagnostics.
Three-Dimensional Image Analysis and Training Method of Action Characteristics of Sanda Whip Leg Technique Based on Wavelet Transform
Authors: Song Lei
Published: September 2022

The whip leg technique is an indispensable offensive action for high-level Sanda athletes in the competition. In order to improve the effective guidance of the action of Wushu Sanda whip leg, based on wavelet transform, the three-dimensional image analysis of Sanda whip leg technical action characteristics, to explore the movement speed of each link of the attacking leg, the contraction form, and force sequence of major muscles or muscle groups and put forward correct and reasonable movement techniques, is expected to provide theoretical basis and reference for coaches and athletes in the training of Sanda whip leg movement. Based on this, this paper attempts to use the three-dimensional image analysis system and surface electromyography acquisition system from the perspective of wavelet transform to collect the speed of the attacking leg movement and the parameters related to muscle discharge and to quantitatively analyze and evaluate its movements. The sequence of activities of the whip leg strike is hip joint-knee joint-hip joint-knee joint-ankle joint. It is suggested to strictly follow the principle of link movement in practice, and the completion of the whole movement should be relaxed and natural.
Neutrosophic Fuzzy Association Rule Generation-Based Big Data Mining Analysis Algorithm
Authors: Wei Qunfeng , Qi Bin
Published: September 2022

As a very common and classic big data (BD) mining algorithm, the association rule data mining (DM) algorithm is often used to determine the internal correlation between different items and set a certain threshold to determine the size of the correlation. However, the traditional association rule algorithm is more suitable for establishing Boolean association rules between different items of different types of data, and hardening the sharp boundaries of the data causes the performance of the association rules to decrease. In order to overcome this shortcoming of classic DM, this article introduces association rules, support and confidence, the Apriori algorithm and fuzzy association rules based on the neutrosophic fuzzy association rule (NFAR). This paper is based on the data set of the supermarket purchase goods database, by drawing a radar chart to describe the correlation between different goods and different item sets support, and confidence calculation based on association rules support. Finally, the association rules are generated. Compared to the results produced by NFAR and ordinary association rules, the accuracy of the NFAR association rules algorithm in small data sets is 88.48%, while the accuracy of traditional association rules algorithm is only 80.87%, nearly 8 percentage points higher. On large data sets, the prediction accuracy of the neutral fuzzy association rules algorithm is 95.68%, while that of the traditional method is only 89.63%. Therefore, the NFAR algorithm can improve the accuracy and effectiveness of DM. This algorithm has great application prospects and development space in big DM and analysis.
Protein Motifs to Hide GA-Based Encrypted Data
Authors: Mawla Noura A. , Khafaji Hussein K.
Published: September 2022

The arms of the Internet octopus have reached the ends of the planet. As it has become indispensable in our daily lives, huge amounts of information are transmitted through this network, and it is growing momentarily, which has led to an increase in the number of attacks on this information. Keeping the security of this information has become a necessity today. Therefore, the scientists of cryptography and steganography have seen a great and rapid development in the previous years to the present day, where various security and protection techniques have been used in these two technologies. In this research, it was emphasized to secure the confidentiality and security of the transmitted data between the sending and receiving parties by using both techniques of encryption and steganography. In contrast, where genetic algorithms and logic gates are exploited in an encryption process, in an unprecedented approach, protein motifs are used to mask the encoded message, gaining more dispersion because there are 20 bases used to represent the protein. The real payload gained ranges between 0.8 and 2.666, which outperforms the algorithms that depend on DNA sequences.
Building Protection Data Release Planning Based on Multifeature Deep Learning
Authors: Guo Chunhuan , Zang Yajun , Gao Yu
Published: September 2022

With the rapid development of China’s economy, the protection of buildings has attracted the attention of many researchers. Although there is no such massive demolition in the past, natural damage still exists. Identify the collected historical building protection data through multifeature deep learning, and provide protection plans through the information in the database. In order to solve the problem of restoration of natural damage more professionally and efficiently, this paper collects the architectural features and restoration methods of each building in different processes through multifeature deep learning based on the current state of building information in China. Based on the collected information, this paper establishes the building information model, and stores and manages the building information. According to the Newton deep learning optimization algorithm, this paper enhances the algorithm to accurately collect building information and uses the collaborative filtering algorithm to provide users with a repair plan. This paper uses the GRU-based recommendation model to pass the threshold cycle unit algorithm for the probability of each building being selected in the list of similar buildings at a time point. Under the two conditions of 10 and 20 recommended numbers, the user coverage rate of the recommended case of deatomized building photos can reach 100%. And this paper recommends high-probability solutions for users to achieve automation, diversification, and intelligence.
Repeated Uniaxial Compression Test of Permeable Friction Courses Mixtures under Seepage Field and Stress Field Coupling
Authors: Xingmei Zhang , Yarui Li , Datian Yang
Published: September 2022

In order to study the variations of the non-Darcy flow permeability coefficient and the porosity of permeable friction courses (PFCs), as well as the effects of the coupled seepage and stress fields on them, repeated uniaxial compression tests were carried out under the coupled action of water and a load. A set of water and load coupling tests were conducted, and a non-Darcy flow permeability coefficient tester was also made. After the PFC-13 specimen was carried out by the repeated uniaxial compression test under the water and load coupling, the total air void ratio and effective air void ratio were measured by the vacuum sealing method, and the non-Darcy flow permeability coefficients were obtained by a non-Darcy flow permeability coefficient tester. It was found that the coupled action of water and a load caused the total air void ratio, effective air void ratio, and permeability coefficient to sharply increase and reduced the number of repeated uniaxial compression cycles. These results are helpful for the design, construction, and maintenance of PFC mixtures.
Hydrate-Bearing Sediment Imaging of Ghost Reflection in Vertical Cable Seismic Data Using Seismic Interferometry
Authors: Wang Linfei , Wang Zhong , Liu Huaishan , Zhang Jin , Xing Lei , Yin Yanxin
Published: September 2022

Marine vertical cable seismic (VCS) collects seismic waves by hydrophone array vertically suspended in seawater to prospect the offshore geological structure and monitor the reservoir. Due to its irregular source-receiver geometry, the primary imaging has narrow illustration coverage. Here, we proposed a cross-correlation transformation based on ghost wave interferometry. This method can transform the ghost reflections from the vertical cable seismic profile into the virtual surface seismic primaries just like those excited by the source and recorded by marine seismic towed-streamer below sea surface. After processing these virtual primaries with conventional method, we can obtain the ghost reflection imaging section with high resolution which effectively extend the illustration footprints in the subsurface. By application of this transform, virtual primaries are generated from the first-order ghost reflections of the actual VCS data. Then, migration of these virtual primaries provides a high-resolution image of hydrate-bearing sediments.
Design of Dual-Band, 4-Ports MIMO Antenna-Diplexer Based on Quarter-Mode Substrate Integrated Waveguide
Authors: Almalki Mansour H. , Affandi Adnan , Syed Avez
Published: September 2022

Here, a compact, dual band, 4-elements multi-input and multi-output (MIMO) antenna diplexer is designed to use in wireless local area network (WLAN) applications. The antenna is accomplished in a planar profile by employing Substrate Integrated Waveguide (SIW) technology. To reduce the size of a single element by 75%, a quarter-mode substrate integrated waveguide (QMSIW) technology is introduced. The QMSIW is realized by bisecting the full-mode SIW along the two magnetic walls and considering the quarter-mode for the operation. Initially, two-QMSIW cavities of distinct dimensions are designed to operate in two frequency bands, 5.2 GHz and 5.8 GHz, respectively. Later, two more radiating elements operating at the same frequencies are integrated with a 2-elements antenna. For better polarization decoupling, the identical elements are placed perpendicular to each other, and a parasitic metallic strip loaded with shorting vias is placed between two identical frequency antenna elements; hence, the port isolation is improved up to −25 dB. The antenna covers a bandwidth of 1.8% in the lower frequency band while 2.2% in the upper frequency band. The antenna prototype is fabricated, and its results are verified with experimental data. It is observed that the measured results are closely following the simulated results.
[Retracted] The Role of 12/15‐Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses
Authors: Tan Ruyu , Yan Bing , Wang Chengshuo , Zhang Luo
Published: September 2022

12/15‐lipoxygenase (12/15‐LOX) is a member of the lipoxygenase family, which can catalyze a variety of polyunsaturated fatty acids (PUFA) to produce different metabolites, such as 12‐hydroxyeicosatetraenoic acid (12‐HETE), 15‐HETE, lipoxin (LX), hepoxilin, resolvin, protectin, and maresins. 12/15‐LOX and its metabolites take part in inflammatory responses and mediate related signalling pathways, playing an essential role in various inflammatory diseases. So the definition, catalytic substrates, metabolites of 12/15‐lipoxygenase, and their roles in inflammatory responses are reviewed in this article.
Factors Affecting Physical Activity of People with Knee Osteoarthritis in Southern Taiwan: A Multiple Logistic Regression Analysis
Authors: Hsu Min-Fen , Hsieh Chun-Man , Chiu Aih-Fung
Published: September 2022

Background. Physical activity (PA) is a basic and initiative conservative management for people with knee osteoarthritis (KOA). This study aimed to explore the potential indicators of PA levels in people with KOA. Methods. We designed a cross-sectional study where people with KOA were consecutively approached by the Orthopedic Outpatient Department in a hospital in southern Taiwan. People older than 50 years that could communicate and consent to the present study were enrolled. As a dependent variable, the Chinese version of the Physical Activity Scale for the Elderly (PASE-C) was used to assess the participant’s PA levels. Considering differences in sex, a PASE-C score cut-off point of 140 for men and 120 for women was used. Participants were then divided into “active” and “inactive” groups. We measured independent variables consisting of the demographic and clinical characteristics, such as comorbidities measured by the Charlson Comorbidity Index (CCI), depression status measured by the Geriatric Depression Scale-5, body mass index, KOA history (<5, 5–<10, and ≥10 years), knee pain (unilateral or bilateral), the severity of symptoms measured by the Western Ontario and McMaster Universities Osteoarthritis Index, and 6-meter preferred walking speed. Multiple logistic regression was performed to identify significant relationships between PA among people with KOA. Results. We analyzed a total of 188 people with KOA (56 men and 132 women) with a mean age of 69.4 ± 7.9 (range: 51 to 90 years). Approximately 72.9% (n = 137) were categorized as “inactive PA,” while 27.1% (n = 51) of participants were categorized as “active PA” (male: 32.1%; female: 25.0%). Multiple logistic regression showed a positive association of 6-meter preferred walking speed with active PA (OR: 7.08; 95% CI:1.14–44.13), whereas advanced age and comorbidity (CCI≥1 vs. CCI<1) were negatively associated with active PA with an OR (95% CI) score of 0.91 (0.86–0.97) and 0.37 (0.15–0.87), respectively. Conclusions. People with KOA require appropriate lifestyle management to increase PA. Walking speed may be an effective factor for predicting PA among people with KOA. Healthcare providers treating KOA patients should be aware of their PA levels, especially those at risk.
Camrelizumab and Apatinib Combined with Radiotherapy Is Effective in Advanced Oligometastatic Non-Small-Cell Lung Cancer
Authors: Ye Wei , Song Zhonghua , Lin Zhongkun
Published: September 2022

Objective. To investigate the effect of camrelizumab + apatinib combined with radiotherapy on the expression of TRIM27, SCC-Ag, and CYFRA21-1 in advanced oligometastatic non-small-cell lung cancer (NSCLC). Methods. A retrospective analysis of patients with oligometastatic NSCLC who were treated at our hospital from January 1, 2021, to March 31, 2022. Patients who met the inclusion criteria were summarized into an observation group (camrelizumab on the basis of the control group), or a control group (radiotherapy combined with oral apatinib). The disease control rate, immune function, changes in the levels of TRIM27, SCC-Ag, CYFRA21-1, and the occurrence of adverse effects were compared between the two groups. Result. There were 86 patients who met the inclusion criteria, with 53 cases in the observation group and 33 cases in the control group. There were significant differences in complete remission (CR, 25/53 vs. 10/33), partial remission (PR, 17/53 vs. 12/33), disease control (DC, 7/53 vs. 4/33), disease progression (DP, 4/53 vs. 7/33), and disease control rate (49/53 vs. 26/33) between the observation group and the control group. There was no significant difference in immune function between the two groups before treatment (

p
>
0.05

). After treatment, the levels of CD3+, CD4+, CD4+/CD8+t cells, and NK cells in the observation group were higher (

p
=
0.015

, 0.035, 0.003, 0.001, respectively), while the level of CD8+t cells was lower (

p
<
0.001

). There were no significant differences in TRIM27, SCC-Ag, or CYFRA21-1 between the two groups before treatment (

p
>
0.05

). After treatment, the observation group had lower levels of TRIM27 (

p
=
0.035

), SCC-Ag (

p
=
0.045

), and CYFRA21-1 (

p
=
0.003

). There was no significant difference in the occurrence of adverse events between the two groups (

p
<
0.05

). Conclusion. Treatment of camrelizumab + apatinib combined with radiotherapy is effective for advanced oligometastatic NSCLC, with mild adverse effects.
Integrated Application of AR Technology Development and Drama Stage Design
Authors: Xu Sicheng , Zhang Gedong
Published: September 2022

With the continuous development of science and technology in China, more and more high-tech tools are appearing in our lives, one of which is AR technology. Augmented reality is now widely used in gaming, e-commerce shopping, and interior design. With the development of digital media technology, contemporary theatre design often incorporates new technologies, one of which is augmented reality, which uses Internet of Things (IoT) technology to build different devices onstage, allowing images from computers to be shown virtually on stage. Augmented reality technology can enhance the appeal of theatre and create a new theatre atmosphere for the audience. At the same time, the deep involvement in the narrative is conducive to the creative transformation and innovative development of the art of theatre in the new media era. The following question is how to make AR technology more suitable to enter the theatre without dramatically affecting the core content of the play. This study will elaborate on the media characteristics and interactive relationship of AR technology and analyse and demonstrate the expansion space brought by augmented reality technology to theatre art by some case studies. In addition, it also attempts to put forward some ideas and suggestions on design aspects such as presentation, communication, and styling and to study the pros and cons of the new technology on theatre stage design so as to make a judgement on the future prospects of AR technology in a wide range of entertainment applications.
Role of Carbon Monoxide in Oxidative Stress-Induced Senescence in Human Bronchial Epithelium
Authors: Cai Meng-yun , Yip Chung-Yin , Pan Kewu , Zhang Yan , Chan Renee Wan-Yi , Chan Wood Yee , Ko Wing-Hung
Published: September 2022

Prolonged or excessive stimulation from inhaled toxins may cause oxidative stress and DNA damage that can lead to stress-induced senescence in epithelial cells, which can contribute to several airway diseases. Mounting evidence has shown carbon monoxide (CO) confers cytoprotective effects. We investigated the effects of CO on oxidative stress-induced senescence in human airway epithelium and elucidated the underlying molecular mechanisms. Here, CO pretreatment reduced H2O2-mediated increases in total reactive oxygen species (ROS) production and mitochondrial superoxide in a human bronchial epithelial cell line (BEAS-2B). H2O2 treatment triggered a premature senescence-like phenotype with enlarged and flattened cell morphology accompanied by increased SA-β-gal activity, cell cycle arrest in G0/G1, reduced cell viability, and increased transcription of senescence-associated secretory phenotype (SASP) genes. Additionally, exposure to H2O2 increased protein levels of cellular senescence markers (p53 and p21), reduced Sirtuin 3 (SIRT3) and manganese superoxide dismutase (MnSOD) levels, and increased p53 K382 acetylation. These H2O2-mediated effects were attenuated by pretreatment with a CO-containing solution. SIRT3 silencing induced mitochondrial superoxide production and triggered a senescence-like phenotype, whereas overexpression decreased mitochondrial superoxide production and alleviated the senescence-like phenotype. Air-liquid interface (ALI) culture of primary human bronchial cells, which becomes a fully differentiated pseudostratified mucociliary epithelium, was used as a model. We found that apical and basolateral exposure to H2O2 induced a vacuolated structure that impaired the integrity of ALI cultures, increased goblet cell numbers, decreased SCGB1A1+ club cell numbers, increased p21 protein levels, and increased SASP gene transcription, consistent with our observations in BEAS-2B cells. These effects were attenuated in the apical presence of a CO-containing solution. In summary, we revealed that CO has a pivotal role in epithelial senescence by regulating ROS production via the SIRT3/MnSOD/p53/p21 pathway. This may have important implications in the prevention and treatment of age-associated respiratory pathologies.
APOBEC3B and CD274 as Combined Biomarkers for Predicting Response to Immunotherapy in Urothelial Carcinoma of the Bladder
Authors: Zhang Chuanhao , Cheng Zhichao , Wang Zhe , Zhao Genghao , Yuan Yonghui , Wang Ruoyu
Published: September 2022

Immunotherapy has become a promising form of treatment for cancers. There is a need to predict response to immunotherapy accurately. In the UCSC Xena, pan-cancer analysis revealed a positive relationship between APOBEC3B (A3B) and tumor mutational burden (

R
=
0.28

,

P
<
0.001

) and microsatellite instability (

R
=
0.12

,

P
<
0.05

). Naturally, the A3B high expression group had higher tumor mutational burden and microsatellite instability than the low expression group. The bladder cancer (BLCA) cohort in The Cancer Genome Atlas (TCGA) revealed tumor mutational signatures of A3B high and low expression groups. Compared to the low expression group, the high expression group had a higher number of SNPs and mutations. Subsequently, A3B was profiled for immune cell infiltration and immune checkpoints in bladder cancer. The results showed that A3B was positively correlated with most immune cells. Compared with the A3B low expression group, the A3B high expression group had higher expression of immune checkpoints. A3B was positively correlated with CD274 (

R
=
0.12

,

P
=
0.016

). This indicated that the high expression of A3B may have a better response to immunotherapy. Furthermore, data from the IMvigor210 immunotherapy clinical trial was used to confirm the findings of this study. The combined survival analysis of A3B and CD274 showed that the group of patients with high expression of CD274 and A3B was found to have a significantly higher survival rate than the rest of the patient group (

P
<
0.047

). The results demonstrated that A3B has a significant role in immunotherapy. Moreover, the combined biomarkers of A3B and CD274 were more effective in predicting response to immunotherapy in bladder urothelial carcinoma. The findings of this study provide valuable insights for precision medicine.
Mastication Wear of Two Low Profile Attachment Systems for Overdenture: An In Vitro Study
Authors: Sassi Alessandra Nicole , Todaro Claudia , Isola Gaetano , Bortolini Ivano , Rodriguez y Baena Ruggero , Storelli Stefano , Lupi Saturnino Marco
Published: September 2022

Background. Edentulism is still a major problem in the world’s population today. Implant‐retained overdenture has proven to be a valid therapeutic solution in the mandible. This type of rehabilitation requires replacement of the matrices when those reach inadequate retention due to wearing processes. This study is aimed at evaluating the drop in retention of low‐profile precision attachments following the application of vertical chewing forces. Two different attachment designs were compared. Methods. This in vitro study simulated an implant‐retained overdenture on an edentulous mandible. Two low‐profile attachments were compared. Loaded and unloaded sides were considered. Tests were performed by exerting a vertical cyclic force on the prosthesis at the level of the first molar of a hemiarch. Retention tests were performed before and after 400.000 chewing cycles, comparable to one year of use. Results. The presence of vertical load wear was identified and characterized. Retention never fell below the values indicated by the manufacturer. Furthermore, significant differences were identified between the two retention systems. Conclusions. Loss of occlusal load retention is a component that must be evaluated by the clinician during the design of implant‐prosthetic rehabilitation, particularly in those cases where elevated occlusal forces or parafunctions are present.