bluuebunny/crossref_metadata_2025 huggingface dataset:
Parenteral Nutrition in Patients with Inflammatory Bowel Disease. Systematic Review, Meta-Analysis and Meta-Regression
Authors: Comeche Jose Miguel , Comino Iris , Atavilla Cesare , Tuells Jose , Gutierrez-Hervas Ana , Caballero Pablo
Published: October 2019

Inflammatory bowel disease (IBD) is a chronic disease mediated by the immune system and characterized by the inflammation of the gastrointestinal tract. This study is to understand how the use of parenteral nutrition (PN) can affect the adult population diagnosed with IBD. We conducted a systematic review, meta-analysis and a meta-regression. On the different databases, (MEDLINE, Scopus, Cochrane, LILACS, CINAHL, WOS) we found 119 registers, the accuracy was 16% (19 registers); After a Full-text review, only 15 research studies were selected for qualitative synthesis and 10 for Meta-analysis and Meta-regression. The variables used were Crohn’s Disease Activity Index (CDAI), albumin, body weight (BW) and post-operative complications (COM). PN has shown to have efficacy for the treatment of IBD and is compatible with other medicines. The CDAI and albumin improve although the effect of PN are greater after a while. However, the effect on the albumin could be less than the observed value in the meta-analysis, due to a possible publication bias. The BW does not change after intervention. COM utilizing PN has been observed, although the proportion is low.
Aptamer Bead-Mediated Separation of Gram-Negative Bacteria Using Acoustophoresis
Authors: Lee Sang Woo , Kim Byungw Woo , Shin Hye-Su , Go Anna , Lee Minho , Lee Dong-ki , Kim Soyoun , Jeong Ok Chan
Published: October 2019

Here, we report a simple and effective method for separation of gram-negative bacteria using aptamer-modified microbeads and acoustophoresis. As acoustophoresis allows for simultaneous washing and size-dependent separation in continuous flow mode, we efficiently obtained gram-negative bacteria that showed high affinity without any additional washing steps. The proposed device has a simple and efficient channel design, utilizing a long, square-shaped microchannel that shows excellent separation performance in terms of the purity, recovery, and concentration factor. Microbeads (10 µm) coated with the GN6 aptamer can specifically bind gram-negative bacteria. Using acoustophoresis, gram-negative bacteria-bound microbeads and other unbound/contaminants can be separated by size with high purity and recovery. The device demonstrated excellent separation performance, with high recovery (up to 98%), high purity (up to 99%), and a high volume rate (500 µL/min), and a concentration factor of up to 20×. The acoustophoresis microfluidic device also showed binding affinity to multiple strains of gram-negative bacteria, but not to gram-positive bacteria. This study presents a new paradigm for early diagnosis of bacterial infectious diseases. In addition to detecting living bacteria or bacteria-derived biomarkers, this protocol can be extended to monitoring the contamination of water resources, and may aid quick responses to bioterrorism and pathogenic bacterial infections.
Topological Quantum Interplay between Magnetic Flux and Mass in an Electron
Authors: Vinciguerra Vincenzo
Published: October 2019

A topological quantum interplay between the magnetic flux and the mass has been investigated, for the case of an electron, by evaluating a gauge-invariant phase factor (a Wilson loop) linked to the electromagnetic gauge field of the particle. In particular, from this phase factor and the quantization of the magnetic flux variations, a relationship between the mass at rest of the electron and its self-energy , arising from radiative corrections, has been obtained also within a QED approach. Besides, a formulation of an energy scale comparable to the energy at rest of an electron-positron pair is proposed. Remarkably, a reckoning of the Bohr energy of a W+ W- pair is compatible with constants and parameters usually employed within the electroweak theory and comparable to the energy at rest of an electron-positron pair.
Quantification of Carotid Intraplaque Hemorrhage: Comparison between Manual Segmentation and Semi-Automatic Segmentation on Magnetization-Prepared Rapid Acquisition with Gradient-Echo Sequences
Authors: Song Young Ju , Kwak Hyo Sung , Chung Gyung Ho , Jo Seongil
Published: October 2019

Purpose: Carotid intraplaque hemorrhage (IPH) increases risk of territorial cerebral ischemic events, but different sequences or criteria have been used to diagnose or quantify carotid IPH. The purpose of this study was to compare manual segmentation and semi-automatic segmentation for quantification of carotid IPH on magnetization-prepared rapid acquisition with gradient-echo (MPRAGE) sequences. Methods: Forty patients with 16–79% carotid stenosis and IPH on MPRAGE sequences were reviewed by two trained radiologists with more than five years of specialized experience in carotid plaque characterization with carotid plaque MRI. Initially, the radiologists manually viewed the IPH based on the MPRAGE sequence. IPH volume was then measured by three different semi-automatic methods, with high signal intensity 150%, 175%, and 200%, respectively, above that of adjacent muscle on the MPRAGE sequence. Agreement on measurements between manual segmentation and semi-automatic segmentation was assessed using the intraclass correlation coefficient (ICC). Results: There was near-perfect agreement between manual segmentation and the 150% and 175% criteria for semi-automatic segmentation in quantification of IPH volume. The ICC of each semi-automatic segmentation were as follows: 150% criteria: 0.861, 175% criteria: 0.809, 200% criteria: 0.491. The ICC value of manual vs. 150% criteria and manual vs. 175% criteria were significantly better than the manual vs. 200% criteria (p < 0.001). Conclusions: The ICC of 150% and 175% criteria for semi-automatic segmentation are more reliable for quantification of IPH volume. Semi-automatic classification tools may be beneficial in large-scale multicenter studies by reducing image analysis time and avoiding bias between human reviewers.
Solar Powered Automatic Pattern Design Grass Cutting Robot System Using Arduino
Authors: Khan Dost Muhammad , Mumtaz Zain , Saleem Majid , Ilyas Zeeshan , Ma Qinglu , Ghaffar Sahrish , ullah Saleem
Published: October 2019

We present an Arduino-based automatic robotic system which is used for cutting grass or lawns, mostly healthy grass which needs to cut neatly like in a public park or a private garden. The purpose of this proposed project is to design a programmable automatic pattern design grass cutting robot with solar power which no longer requires time-consuming manual grass-cutting, and that can be operated wirelessly using an Android Smartphone via Bluetooth from a safe distance which is capable of cutting the grass in indeed required shapes and patterns; the cutting blade can also be adjusted to maintain the different length of the grass. The main focus was to design a prototype that can work with a little or no Physical user interaction. The proposed work is accomplished by using an Arduino microcontroller, DC geared Motors, IR obstacle detection sensor, motor shield, relay module, DC battery, solar panel, and Bluetooth module. The grass-cutting robot system can be moved to the location in the lawn remotely where the user wants to cut the grass directly or in desired patterns. The user can press the desired pattern button from the mobile application, and the system will start cutting grass in the similar design such as a circle, spiral, rectangle, and continue pattern. Also, with the assistance of sensors positioned at the front of the vehicle, an automatic barrier detection system is introduced to enhance safety measurements to prevent any risks. IR obstacle detector sensors are used to detect obstacles, if any obstacle is found in front of the robot while traveling; it avoids the barrier by taking a right/right turn or stop automatically appropriately, thereby preventing the collision. Also, the main aim of this project is the formation of a grass cutter that relieves the user from mowing their own grasses and reduces environmental and noise pollution. The proposed system is designed as a lab-scale prototype to experimentally validate the efﬁciency, accuracy, and affordability of the systems. The experimental results prove that the proposed work has all in one capability (Simple and Pattern based grass cutting with mobile-application, obstacle detection), is very easy to use, and can be easily assembled in a simple hardware circuit. We note that the systems proposed can be implemented on a large scale under real conditions in the future, which will be useful in robotics applications and cutting grass in playing grounds such as cricket, football, and hockey, etc.
Exponential Disruptive Technologies and the Required Skills of Industry 4.0: A Review
Authors: Bongomin Ocident , Ocen Gilbert Gilibrays , Nganyi Eric Oyondi , Musinguzi Alex , Omara Timothy
Published: October 2019

The 21st century has witnessed a number of incredible changes ranging from the way of life and the technologies that emerged. Currently, we have entered a new paradigm shift called industry 4.0 where science fictions have become science facts, and technology fusion is the main driver. Therefore, ensuring that any advancement in technology reach and benefit all is the ideal opportunity for everyone. In this paper, disruptive technologies of industry 4.0 have been explored and quantified in terms of the number of their appearances in literature. This research mainly aimed at identifying industry 4.0 key technologies which have been ill-defined by previous researchers and to enlighten the required skills of industry 4.0. Comprehensive literature survey covering the field of engineering, production, and management from both academia and business was done from publication databases: Google scholar, ScienceDirect, Scopus, Sage, Taylor & Francis and Emerald insight. The results of the study show that 35 disruptive technologies were quantified and 13 key technologies: Internet of things, Big data, 3D printing, Cloud computing, Autonomous robots, Virtual and augmented reality, Cyber physical system, Artificial intelligence, Smart sensors, Simulation, Nanotechnology, Drones and Biotechnology were identified. Moreover, both technical and personal skills to be imparted into the human workforce for industry 4.0 were identified. The study reveals the need to investigate the capabilities and the readiness of some developing countries in adapting industry 4.0 in terms of the changes in the education systems and industrial manufacturing settings. In addition, the study proposes the need to address the ways for integration of industry 4.0 concepts into the current education system.
Critical Commentary: Need for an Integrated Deprived Area “Slum” Mapping System (IDeAMapS) in LMICs
Authors: Thomson Dana , Kuffer Monika , Boo Gianluca , Hati Beatrice , Grippa Tais , Elsey Helen , Linard Catherine , Mahabir Ron , Kyobutungi Catherine , Mulandi Joshua , Mwaniki Dennis , Ndugwa Robert , Makau Jack , Sliuzas Richard , Cheruiyot Salome , Nyambuga Kilion , Mboga Nicholus , Wanjiru Nicera , Porto De Albuquerque Joao , Kabaria Caroline
Published: October 2019

Ninety percent of the people added to the planet over the next 30 years will live in African and Asian cities, and a large portion of these populations will reside in deprived neighborhoods defined by slum conditions, informal settlement, or inadequate housing. The four current approaches to neighborhood deprivation mapping are largely silo-ed, and each fall short of producing accurate, timely, comparable maps that reflect local contexts. The first approach, classifying “slum households” in census and survey data and aggregating to administrative areas, reflects household-level rather than neighborhood-level deprivation. The second approach, field-based mapping, can produce the most accurate and context-relevant maps for a given neighborhood, however it requires substantial resources, preventing up-scaling. The third and fourth approaches, human interpretation and machine classification of satellite, aerial, or drone imagery, both overemphasize informal settlements, and fail to represent key social characteristics of deprived areas such as lack of tenure, exposure to pollution, and lack of basic public services. The latter, machine classification of imagery, can be automated and extended to incorporate new and multiple sources of data. This diverse collection of authors represent experts from these four approaches to neighborhood deprivation mapping. We summarize common areas of understanding, and present a set of requirements to produce maps of deprived urban areas that can be used by local-to-international stakeholders for advocacy, planning, and decision-making.
ALTERNATIVE DEVELOPMENT FROM FORDISM TO NICHISM FOR ASIAN AGRICULTURE IN GLOBALIZING ERA
Authors: Kawamura Yoshio
Published: October 2019

The 21st Century has become a more globalized society which is directly associated with very quick development of high technology in the field of information science. Any country has to face the problem to develop itself under this international environment. Especially agriculture is the most difficult industry to adjust this change because of its peculiarity which is directly determined by the natural and social environment within the country. This paper deals with a basic strategy for agricultural development in the globalizing economy, based on its socioeconomic characteristics. The paper argued that the relationship between industries and economic globalization is directly determined by the combinations of mobility of inputs (resources) and mobility of outputs (products). Most of industries have a significant positive correlation between these mobility but agriculture is placed in a peculiar position: land, which is the most important and basic input for agricultural production, has no mobility and can be supplied only locally, while its outputs, farm products or food, are traded commodities with a relatively high degree of mobility and are demanded globally across national boundaries. For this reason, agriculture is the industry for which it is most difficult to cope with globalization. This paper clarifies the peculiarity of agriculture by socioeconomic approach to get a sustainable development in globalizing economy.
FOOD CONSUMPTION AND PRODUCTION IN TEMPE LAKE, SOUTH SULAWESI, INDONESIA
Authors: Ali M. Saleh S. , Majika Amrullah , Salman Darmawan
Published: October 2019

Challenges in providing sufficient food is a society problem and it will exist along with human civilization history.In this modern civilization, when the population reach more than 7 million people in the world, food consumption and production become a civilization problem and nature becomes a victim of it. Nowadays, almost 1 million people facing undernutrition and malnutritionThis study aimed to identify the pattern of food consumption and production in Tempe Lake, the biggest lake in the province or in Sulawesi island. A fieldwork conducted on February 2016 at Laelo Village (Kelurahan Laelo) that belongs to Tempe Sub-district (Kecamatan Tempe).  Total respondents in this study were 72 people who were selected randomly from those have use the lake as main source of livelihood. Some informants who know more about the lake were also interviewed. Data gathered mainly about  land use of the lake during dry season and wet (flood) season, and food consumption and production pattern, This research found that fish production of the lake has decreased significantly in the last 20 years due to sedimentation, overfishing and environmental contamination.   People consumed various foods for their dietary but mostly consuming rice that they purchased from market and fish and vegetables from the lake. There was no different in amount of rice and fish consumed during wet and dry season.
ASSESSMENT OF GENDER ACCESS TO AGRICULTURAL LOANS FROM COOPERATIVE SOCIETIES IN DEKINA LOCAL GOVERNMENT AREA OF KOGI STATE, NIGERIA
Authors: P.E Adejo , E.G Adejo , U.M Shaibu
Published: October 2019

This study assessed gender access to agricultural loans from cooperative societies in Dekina Local Government Area of Kogi State, Nigeria. Primary data used were collected from 160 registered cooperative members in the study area. Data collected were analysed using descriptive statistics, binary Logit regression analysis, and mean score. Results of the findings showed that 62.9% and 54.3% of the male and female cooperative members were married with household size of 1 – 5 members. Most of the respondents were within the age bracket of 31 – 50 years. Finding on gender difference indicated that male cooperative members had more access (3.52) to loan than the female (2.88). Estimates of the binary logit model showed that the slope coefficients of household size, educational status, years of membership, and income were positive and statistically significant at 10% and 5% for the male and female cooperative members respectively. Furthermore, the major problems faced by cooperative members in accessing loans are reluctance from financial institutions (M=2.8) and fear of repayment by borrowers (M=2.7). Amongst others, comprehensive development of gender specific policy interventions by government to enhance access to loan by female cooperative members was recommended.
Sublacustrine geomorphology and modern sedimentation in a glacial scour basin, June Lake, eastern Sierra Nevada, U.S.A.
Authors: Lyon Eva C. , McGlue Michael M. , Woolery Edward W. , Kim Sora L. , Stone Jeffery R. , Zimmerman Susan R.H.
Published: October 2019

Small sub-alpine glacial lakes are often targeted as Holocene paleoclimate archives, but their evolution as landforms and depositional basins is understudied. At June Lake in the eastern Sierra Nevada of California (USA), bathymetry, surface sediment composition, and seismic stratigraphy are studied to assess the modern sedimentary system and gain insight into the basin's origins. A basin-wide seismic survey reveals sublacustrine morphological features that attest to the role of ice in scouring the June Lake basin, including a prominent abraded bedrock shoal and an adjacent overdeepened depression. The seismic survey reveals four acoustically distinct stratigraphic units that reflect the history of sedimentation following glacial scouring. The youngest of these is represented in the recovered lacustrine core records as hemipelagically deposited, organic-rich, laminated diatomaceous oozes alternating with coarse tephra beds. The organic-rich oozes are characterized by low carbon and nitrogen stable-isotope values and occur in profundal areas of the modern lake floor. These sediments suggest an algae-dominated productivity regime and preservation of organic matter at depth. With no perennial streams entering June Lake, surface-sediment grain-size distribution and geochemistry are controlled by water depth and basin morphology. Additional modern facies types include poorly sorted coarse detrital landslide deposits below steep basin walls and volcaniclastic sandy gravel in windward littoral areas. These data provide a modern facies model for sedimentation in ice-scoured, hydrologically closed sub-alpine lakes and a baseline for future paleoclimate studies using June Lake sediment cores.
Comparison of open liver resection and RFA for the treatment of solitary 3-5 cm hepatocellular carcinoma: a retrospective study
Authors: Lei Jianyong , Yan LN , Li DJ , Wang WT
Published: October 2019

Aim: The goal of this study was to compare the postoperative results of liver resection and radiofrequency ablation (RFA) for the treatment of small hepatocellular carcinoma (HCC) (3-5 cm).
Patients and methods: We retrospectively collected 122 patients with small solitary HCC treated at our center from Jan 2011 to Dec 2015, with diameters in the range of 3-5 cm. According to the treatment program received at our center, they were divided into the liver resection group (72 patients) and the RFA group (50 patients).
Result: In comparison with the RFA group, the resection group had a longer operative time, and greater intra-operative blood loss (P<0.01), more hepatic inflow occlusion, and longer postoperative hospital stay (P<0.01). The 1-, 3-, and 5-year expected overall survival rates and tumor-free survival rates were comparable between the two groups. Cox regression analysis showed that resection or RFA was not a significant risk factor for overall or tumor-free survival for HCC.
Conclusions: For solitary HCC of 3-5 cm in diameter, RFA can achieve better in-hospital clinical results and similar long-term outcomes, and RFA can be considered for wide application, especially for central cases.
Generation of Gaussian 09 Input Files for the Computation of 1H and 13C NMR Chemical Shifts of Structures from a Spartan’14 Conformational Search
Authors: Willoughby Patrick , Reisbick Spencer
Published: October 2019

This protocol describes an approach to preparing a series of Gaussian 09 computational input files for an ensemble of conformers generated in Spartan’14. The resulting input files are necessary for computing optimum geometries, relative conformer energies, and NMR shielding tensors using Gaussian. Using the conformational search feature within Spartan’14, an ensemble of conformational isomers was obtained. To convert the structures into a format that is readable by Gaussian 09, the conformers were first exported to a single “.sdf” file. A Python script was used to \(i) read the structural information of each conformer within the “.sdf” file and \(ii) write the corresponding atomic coordinates into a series Gaussian 09 input files. This approach decreases the amount of active effort required to compute NMR chemical shifts of a structure that populates an ensemble of conformers.
Contaminating reactivity of a monoclonal CCAAT/Enhancer Binding Protein β antibody in differentiating myoblasts
Authors: AlSudais Hamood , Wiper-Bergeron Nadine
Published: October 2019

Objective
CCAAT/Enhancer Binding proteins (C/EBPs) are transcription factors involved in the regulation of a variety of cellular processes. We used the Abcam Recombinant Anti-C/EBP beta antibody (E299) to detect C/EBPβ expression during myogenesis. Though the antibody is monoclonal, and the immunogen used is highly specific to C/EBPβ, we identified an intense band at 23 kDa on western blot that did not correspond to any of the known isoforms of C/EBPβ, or family members predicted to cross-react. Absent in myoblast cells overexpressing C/EBPβ, the band was present when C/EBPβ was knocked down, confirming specificity for a protein other than C/EBPβ. The objective of this work was to identify the contaminating reactivity.
Results
We performed immunoprecipitation followed by mass spectrometry to identified myosin light chain 4 (MYL4) as the unknown band, suggesting that the Abcam monoclonal antibody directed against C/EBPβ is not pure, but contains a contaminating antibody against MYL4. Caution should be used when working in cells lines that express MYL4 to not confound the detection of MYL4 with that of C/EBPβ isoforms.
Controlled Trial to compare the Achilles Tendon load during running in flatfeet participants using a customized arch support orthoses vs an orthotic heel lift
Authors: Lee Kawin KW , Ling Samuel Ka Kin , Yung Patrick SH
Published: October 2019

Achilles tendinopathy is one of the most common overuse injuries in running, and forefoot pronation, seen in flatfeet participants, has been proposed to cause additional loading across the Achilles tendon. Foot orthoses are one of the common and effective conservative treatment prescribed for Achilles tendinopathy, it works by correcting the biomechanical malalignment and reducing tendon load. Previous studies have shown reduction of Achilles Tendon load (ATL) during running by using customized arch support orthosis (CASO) or an orthotic heel lift (HL). However, there are still little biomechanical evidence and comparative studies to guide orthotic prescriptions for Achilles tendinopathy management. Therefore, this study seeks to investigate the two currently employed orthotic treatment options for Achilles tendinopathy: CASO and HL for the reduction of ATL and Achilles tendon loading rate (ATLR) in recreational runners with flatfeet.
Methods:
12 participants were recruited and run along the runway in the laboratory for three conditions: (1) without orthoses, (2) with CASO (3) with HL. Kinematic and kinetic data were recorded by 3D motion capturing system and force platform. Ankle joint moments and ATL were computed and compared within the three conditions.
Results:
Participants who ran with CASO (p=0.001, d=0.43) or HL (p=0.001, d=0.48) associated with a significant reduction in ATL when compared to without orthotics. There was no difference between the two types of orthoses, the mean peak ATL of CASO was slightly lower than HL. Regarding the ATLR, both orthoses, CASO (p=0.003, d= 0.93) and HL (p=0.004, d= 0.78), exhibited significant lower value than the control but similarly, no significant difference was noted between them in which the use of CASO yielded a slightly lower loading rate than that of HL.
Conclusion:
Both CASO and HL were able to cause a significant reduction in peak ATL and ATLR comparing to without orthotics condition. There were subtle but no statistically significant differences in the biomechanical effects between the two types of orthoses. The findings help to quantify the effect of CASO and HL on load reduction of Achilles tendon and suggests that foot orthoses may serve to prevent the incidence of Achilles tendon pathologies.
Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort
Authors: Hassiotis Angela , Brown Emma , Harris James , Helm David , Munir Kerim , Salvador-Carulla Luis , Bertelli Marco , Baghdadli Amaria , Wieland Jannelien , Novell-Alsina Ramon , Cid Jordi , Vergés Laura , Martínez-Leal Rafael , Mutluer Tuba , Ismayilov Fuad , Emerson Eric
Published: October 2019

Background: To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity.
Methods: We performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predict adult mental distress as measured by the Malaise Inventory. Factor analysis was used to derive a proxy measure of IQ from cognitive testing at age 10 or 5. Variables that could be indicators of exposure to Adverse Childhood Experiences were identified and grouped into health related and socio-economic related adversity.
Results: Children with BIF were significantly more likely than their peers to have been exposed to Adverse Childhood Experiences (BIF mean 5.90, non-BIF mean 3.19; Mann-Whitney z=31.74, p<0.001). As adults, participants with BIF were significantly more likely to score above the cut-off on the Malaise Inventory. We found statistically significant relationships between the number of socio-economic Adverse Childhood Experiences and poorer adult psychiatric morbidity (r range 0.104-0.141, all p<001). At all ages the indirect mediating effects of Adverse Childhood Experiences were significantly related to adult psychiatric morbidity.
Conclusions: The relationship between BIF and adult psychiatric morbidity appears to be partially mediated by exposure to Adverse Childhood Experiences. Where possible, targeting Adverse Childhood Experiences through early detection, prevention and interventions may improve psychiatric morbidity in this population group.
Heart rate agreement between the 20-meter shuttle run test and virtual system in healthy children: a cross-sectional study
Authors: moran cristiane , CORSO SIMONE DAL , BOMBIG MARIA TERESA , SERRA ANDREY JORGE , PEREIRA SILVANA ALVES , PECCIN MARIA STELLA
Published: October 2019

Background: Earlier studies evaluated the physiological responses to video games in children with different clinical conditions; however, no study has compared active video games with an incremental field test in healthy children. The purpose of this study was to verify the agreement between the 20-meter shuttle run test (20m-SRT) and virtual system (VS). Methods : This is a cross-sectional study of 235 children (9.0 ± 0.8 years, 109 boys). The two tests were performed one week apart and the children were instructed not to engage in any physical exercise or sports in the 24 hours preceding each test. Their resting heart rate was monitored for one minute and then throughout the tests. To evaluate the influence of motivation on the 20 m SRT and (VS), at the end of the tests the children were asked to rate their motivation on a scale of zero to 10, zero being “not cool” and 10 “awesome”. Perceived exertion at the end of the tests was assessed using the modified Borg scale. Results : Maximum heart rate (HRmax) did not differ between the 20m-SRT and VS (194.4 ± 10.2 bpm vs. 193.2 ± 13.8 bpm, respectively). Both tests were similar for intensity > and < 96% HRmax. The children showed greater exertion on the Borg scale and motivation during the VS. The multiple logistic regression model showed that motivation (p=0.98), sex (p=0.53), age (p=0.61), nutritional status (p=0.65), and speed (p=0.18) were not predictive factors of the child’s reaching HRmax. Conclusion : VS can be used as a tool to evaluate the intensity of maximal exercise tests, given that the percentage of children who achieved HRmax did not differ between the VS and 20m SRT. The perceived exertion scales were correlated, but only the modified Borg scale correlated with HRmax in the 20m SRT. The tests are motivational, and most children obtained the maximum VS score.
Keywords: cardiology; child; exercise; physical fitness; virtual reality; Incremental stress test
Accuracy of Planar Anteversion Measurements using Anteroposterior Radiographs
Authors: Lee Gwang Chul , Lee Sang Hong , Kang Sin Wook , Park Hyung Suk , Jo Suenghwan
Published: October 2019

Introduction
Several methods have been suggested to measure anteversion of the cup component after total hip arthroplasty using simple anteroposterior (AP) radiographs. Herein, we compared six widely used anteversion measurement methods using two different AP radiographs (conventional pelvis AP vs. hip-centered AP) in order to identify the measurement method and radiograph that provide the highest accuracy and reliability.

Methods
We developed two custom-made bi-planar anteversion measurement models for the validation. Each model was designed for pelvis AP and hip-centered AP radiographs. The radiographs were acquired with both models’ inclination angle changing from 10° to 70° at 10° increments, and for each inclination angles, anteversion was changed from 0° to 30° at 5° increments. The measurements were obtained independently by two orthopedic surgeons blinded from each other using 6 methods: 1) Pradhan et al., 2) Lewinnek et al., 3) Widmer et al., 4) Liaw et al., 5) Hassan et al., and 6) Ackland et al. The measurements were repeated after 2 months. The accuracy, compared to the reference angle, and intra- and inter-observer reliabilities of each method were calculated.

Results
The highest accuracy was found when Liaw et al.’s method was used in hip-centered AP radiographs, which showed a difference of 1.37° ± 1.73 from the reference. Moreover, regardless of the type of the radiograph, the methods by Pradhan et al., Lewinnek et al., and Liaw et al. showed excellent correlations with the reference anteversion. However, substantial differences were found when the methods by Widmer et al., Hassan et al., and Ackland et al. were utilized, regardless of the type of radiograph used. When the anteversion was measured in the inclination between 30° and 50°, Pradhan et al.’s method in pelvis AP radiographs showed the highest accuracy (1.23° ± 0.92°). We also found no significant difference when the measured anteversions were compared between pelvis AP and hip-centered AP radiographs. Both inter- and intra-observer reliabilities were high for all measurements tested.

Conclusions
The methods by Pradhan et al., Liaw et al., and Lewinnek et al. may provide relatively accurate anteversion measurements with high reliability, regardless of the type of radiograph.
Postoperative diastolic perfusion pressure is associated with the development of acute kidney injury in patients after cardiac surgery: A retrospective analysis
Authors: Jin Jifu , Yu Jiawei , Chang Su Chi , Xu Jiarui , Xu Sujuan , Jiang Wuhua , Shen Bo , Zhuang Yamin , Wang Chunsheng , Ding Xiaoqiang , Teng Jie
Published: October 2019

Background:We aimed to investigate the relationship between the perioperative hemodynamic parameters and the occurrence of cardiac surgery-associated acute kidney injury.
Methods:A retrospective study was performed in patients who underwent cardiac surgery at a tertiary referral teaching hospital. Acute kidney injury was determined according to the KDIGO criteria. We investigated the association between the perioperative hemodynamic parameters and cardiac surgery-associated acute kidney injuryto identify the independent hemodynamic predictors for acute kidney injury.Subgroup analysis was further performed in patients with chronic hypertension.
Results:Among 300 patients, 29.3% developed acute kidney injury during postoperative intensive care unit period. Multivariate logistic analysis showed the postoperative nadir diastolic perfusion pressure, but not mean arterial pressure, central venous pressure and mean perfusion pressure, was independently linked to the development of acute kidney injury after cardiac surgery (odds ratio 0.945, P= 0.045). Subgroup analyses in hypertensive subjects (n = 91)showed the postoperative nadir diastolic perfusion pressure and peak central venous pressure were both independently related to the development of acute kidney injury (nadir diastolic perfusion pressure, odds ratio 0.886, P= 0.033; peak central venous pressure, odds ratio 1.328, P= 0.010, respectively).
Conclusions:Postoperative nadir diastolic perfusion pressure was independently associated with the development of cardiac surgery-associated acute kidney injury. Furthermore, central venous pressure should be considered as a potential hemodynamic target for hypertensive patients undergoing cardiac surgery.
Genome-Wide identification and Analysis of the AP2/ERF Gene Family in Fragaria vesca
Authors: Li Zekun , Hong Yanhong , Chen Changmei , Wang Zhennan , Zheng Aiying , Chen Jianqing , chen qingxi
Published: October 2019

Background: The AP2/ERF superfamily consists of primary transcription factors in plants that play a critical role in numerous aspects of various physiological stages and responses to stress stimuli. Nevertheless, there is little information related to AP2/ERF in strawberry, an important perennial fruit and model plant for horticulture. Results: In this study, 117 AP2/ERF genes were identified in strawberry and were grouped into four types of genes, AP2 (17), ERF (94), RAV (5) as well as soloist (1), according to the gene structure, phylogenetic tree and conserved domains. The duplication events and synteny analysis combination of genes offered a good opportunity to understand the evolutionary process of the FvAP2/ERF family. Moreover, identified orthologous genes and expression profiles of genes across various tissue, developmental stages and different treatments predicted potential functions of some AP2/ERF genes in strawberry. Conclusions: In this study, 117 genes were identified in the AP2/ERF family of strawberry, and their structure, chromosomes location, evolutionary relationship, promoter sequence and expression profile were investigated. Our findings provide valuable clues to gain better insights into each FvAP2/ERF gene under different types of biological developments and in response to stressors.
Superoxide dismutase gene polymorphism is associated with ischemic stroke risk in the Chinese Han population
Authors: Xitong Yang , Sulian Yang , Hongyang Xu , Yuanyuan Zhang , guangming wang
Published: October 2019

Background:Stroke is a serious cardiovascular disease and a major cause of disability and death in both developed and developing countries. Superoxide dismutases (SODs ) are enzymes that catalyze the breakdown of superoxide into oxygen and hydrogen peroxide and play a key role in the antioxidant response. This study explored the relationship between single nucleotide polymorphisms (SNPs) in SOD genes and the risk of ischemic stroke (IS) in the Chinese Han population of Dali city.Methods: For this case-control study, we enrolled 144 IS patients and 128 healthy controls. The SNPs rs17880487 and rs80265967 of the SOD1 gene, rs4880 and rs284296 of the SOD2 gene, rs2695232 and rs7655372 of the SOD3 gene were detected via Taqman-polymerase chain reaction (PCR). Genotypes and allele frequencies of the two groups were compared. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression, and environmental factors were corrected with multivariate logistic regression analysis.Results: Rs7655372 of SOD3 was associated with a significantly increased risk of IS. Moreover, this the G and GA genotypes of SNP rs7655372 were associated with an increased risk of IS, whereas the A and GA genotypes were risk factors for IS. Furthermore, multivariate logistic regression analysis showed that fasting blood glucose level, red blood cell count, white blood cell count, low-density lipoprotein level, systolic pressure, diastolic pressure, and rs7655372 GA/GG were independent risk factors for IS.Conclusions: The SOD3 gene rs7655372 locus polymorphism is a risk factor for IS, and its frequency in the Chinese Han population of Dali City denotes that this population is at increased risk of IS.
Vancomycin Resistance Enterococcus in Africa in Onehealth approach: A systematic review and meta-analysis
Authors: Begashaw Tsegaye Alemayehu , Hailemariam Mengistu
Published: October 2019

Background Vancomycin resistance enterococci are enterococci that cannot be cured with vancomycin treatment. To combat this resistance, an integrated disciplinary action is mandatory. Therefore, this study aimed to show the prevalence of these agents with the concept of one health approach.Methods Literature search was conducted on PubMed, Google scholar and Hinari with the term “Vancomycin resistance enterococcus in Africa” in august 1-3, 2019. All available articles exported to “Endnote version 7.1” then to Microsoft word. All the articles checked to meet our criteria for the review. Those articles reported the prevalence of vancomycin resistance Enterococcus and published from 2010 to present in the English language was included for the review. There were 151 articles from the databases; of this, 37 articles included after extensive review with two independent authors.Result Out of 4112 samples collected, 1527 isolates identified with overall magnitude of VRE as 28.8% (12.9%-44.7%) in Africa with a one-health perspective. The meta-analysis indicates that there was substantial heterogeneity among the articles with consistency index (I 2 ) =99.9%. A higher rate of Vancomycin resistance enterococci was identified from South Africa 74.8%, followed by Egypt 37. 2%. Laboratory method employed for identification showed that a higher rate was from BacTec 98.8%, followed by PCR 59.2%. It is also a non-human sample source was with higher rates of VRE i.e. 32.5%.Conclusion This meta-analysis indicates there was a high rate of Vancomycin resistance enterococcus in African continent. A lot should be done to prevent and control the transmition of this resistance gene circulating in the environment.
Semi-constrained posterior stabilized total knee arthroplasty reproduces natural deep knee bending kinematics
Authors: Sumino Takanobu , Tomita Tetsuya , Sugamoto Kazuomi , Yamazaki Takaharu , Okazaki Ken
Published: October 2019

Background The Flexible Nichidai Knee Posterior Stabilized (FNK-PS) system was designed to provide relatively high varus-valgus stabilities without the stem extensions to patients with severe knee joint disorders. This is a combination of a large tibial post and high femoral cam adapted to a PS system. The aim of our study was to analyze the in vivo two-dimensional/three-dimensional registration kinematics of the FNK PS-total knee arthroplasty (TKA) system during deep knee bending.Methods Nineteen knees from 15 total knee arthroplasty (TKA) patients who were able to squat with enough knee flexion were selected. During deep knee bending under weight bearing (WB) and non-weight bearing (NWB) conditions, we quantified range of motion, axial rotation, femoral anteroposterior translation, and post-cam engagement angle.Results The maximum-flexion was significantly different between the two conditions. The mean axial femoral external rotation was 4.8° and 6.2° under WB and NWB conditions, respectively, at 120° flexion. Anteroposterior translation based on bicondylar posterior roll-back patterns was noted with increasing knee flexion. Both the medial and lateral femoral aspects were significantly more posterior during early to mid-flexion. Initial post-cam engagement occurred significantly earlier during flexion under NWB than under WB conditions. Under WB, the timing of the post-cam engagement correlated with the maximum flexion.Conclusions The kinematics of the semi-constrained PS system reproducibly exhibited a mild external rotation with smooth posterior roll-back, comparable to that of standard PS-TKAs. This was assisted by the engagement of the large tibial post and high femoral cam during the early phase of flexion.
Psychological resilience and health-related quality of life in Swedish women with newly diagnosed breast cancer
Authors: Mohlin Åsa , Axelsson Ulrika , Bendahl Pär-Ola , Borrebaeck Carl A. K. , Hegardt Cecilia , Johnsson Per , Hallberg Ingalill Rahm , Rydén Lisa
Published: October 2019

Purpose Psychological resilience appears to be an important influencing factor in various aspects of health-related quality of life (HRQoL) in a context of adversity, e.g., being informed of a cancer diagnosis. The purpose was to investigate psychological resilience and health-related quality of life in Swedish women with newly diagnosed breast cancer in relation to demographic and clinicopathological characteristics.Methods A population-based cross-sectional study was conducted including 517 women with breast cancer in the South Swedish Health Care Region. Participants were enrolled at the time of consultation for the diagnosis. Psychological resilience was assessed with the Connor-Davidson Resilience Scale 25 (CD-RISC25), and HRQoL was assessed with the Short Form Health Survey. The participants responded to questions regarding demographic variables. Clinicopathological data were collected from the Swedish National Quality Register for Breast Cancer.Results The mean score for psychological resilience was 70.6, identifying 15% of included patients with a score lower than 58 (-1 standard deviation). The study cohort had significantly lower mean scores for several aspects of HRQoL compared with Swedish normative data. Multiple regression analyses demonstrated that psychological resilience was significantly associated with all domains of HRQoL after adjustment for demographic and clinicopathological factors.Conclusions Higher levels of psychological resilience were significantly related to higher levels of HRQoL in Swedish women with newly diagnosed breast cancer and no modifying factor was identified. The assessment of psychological resilience at the time of breast cancer diagnosis might allow for early identification of women in need of more intense psychosocial support. Future studies are needed to identify a clinically relevant threshold of the CD-RISC25.
Attitude, Practice and its Associated Factors towards Diabetes Complications among Type 2 Diabetic Patients at Addis Zemen District Hospital, Northwest Ethiopia
Authors: belsti yitayeh , Akalu Yonas , Animut Yaregal
Published: October 2019

Background The aim of this study was to assess the level of attitude, practices, and its associated factors towards complications of diabetes mellitus among type 2 diabetes patients.Methods A cross-sectional study was conducted among Type 2 diabetes patients visiting the diabetes clinic at Adiss Zemen District Hospital in Northwest Ethiopia. Interviewer administered structured questionnaire was used to collect data from 402 patients. Multivariable logistic regression was used to determine factors associated with attitudes and practices towards diabetes complications. AOR with 95% CI and p-value less than 0.05 was considered to identify significant associated factors.Results Two third of the study participants 65.5% (95% CI: 60.2, 69.4) had a good attitude level while less than half of study participants 48.8% (95% CI: 44.0, 53.5) had a good practice on diabetes complications. Educational status of: read and write (AOR=2.32, 95% CI=1.26 4.27), primary school (AOR= 4.31, 95% CI= 2.06, 9.02), high school and above (AOR=2.79, 95% CI=1.41, 5.50), and urban residence (AOR=1.80, 95% CI=1.12 2.91) were significant factors for good attitude while educational status of: read and write (AOR=1.96, 95% CI=1.06, 3.61), high school and above (AOR=2.57, 95% CI=1.32, 5.02) were associated with diabetes complication practices.Conclusions Greater proportion of diabetes patients had relatively good attitude but poor practice towards diabetes complication preventions. Residence was significant contributing factor for good attitude whereas educational status was significantly associated with both attitude and practice. The current study suggests the need of structured educational programs about diabetes complications on a regular basis to improve patient’s attitude and practice.
Growth and Photosynthetic Capacity of Basil Grown for Indoor Gardening under Constant or Increasing Daily Light Integrals
Authors: Solis-Toapanta Elisa , Gómez Celina
Published: October 2019

In the quest to identify minimum daily light integrals (DLIs) that can sustain indoor gardening, we evaluated DLIs less than the recommended ranges for commercial production of basil (Ocimum basilicum). Experiments were conducted for 8 weeks to evaluate the effect of providing a constant vs. an increasing DLI over time (DLIInc) on growth and photosynthetic capacity of green (‘Genovese Compact’) and purple (‘Red Rubin’) basil grown hydroponically under a constant ambient temperature of 21 °C. Plants were grown under a 14 h·d–1 photoperiod and were subjected to the following DLI treatments: 4 (DLI4), 6 (DLI6), 8 (DLI8), or 10 (DLI10) mol·m–2·d‒1 (80, 119, 159, and 197 µmol·m‒2·s‒1, respectively); DLIInc was used as a fifth treatment and was achieved by transitioning hydroponic systems systematically to treatments with greater DLIs every 2 weeks. In general, regardless of cultivar, leaf area, leaf number, and overall growth [shoot fresh weight (SFW) and shoot dry weight (SDW)] were similar for plants grown under DLIInc to DLI4 and DLI6 during weeks 2, 4, and 6. However, plants grown under DLIInc produced the same leaf area as those grown under DLI10 at week 8. Nonetheless, across weeks, growth was significantly less under DLIInc compared with DLI10, but similar to that produced by DLI8 at week 8. Photosynthetic responses were significant only at week 8, for which leaves of plants grown under DLI8, DLI10, and DLIInc had 15% to 25% greater maximum gross carbon dioxide (CO2) assimilation (Amax) than plants grown under DLI4. The light saturation point of photosynthesis was unaffected by DLI, but showed a general increasing trend with greater DLIs. Overall, our results suggest that providing a constantly high DLI results in greater growth and yield than increasing the DLI over time. In addition, we found that changes in Amax and the light saturation point are not good indicators of the capacity of whole plants to make use of the available light for photosynthesis and growth. Instead, morphological and developmental traits regulated by DLI during the initial stages of production are most likely responsible for the growth responses measured in our study.