bluuebunny/crossref_metadata_2025 huggingface dataset:
21st century medicine and emerging biotechnological syndromes: a cross- disciplinary systematic review of novel patient presentations in the age of technology
Authors: Straw Isabel , Rees Geraint , Nachev Parashkev
Published: May 2023

BackgroundBiotechnological syndromes refer to the illnesses that arise at the intersection of human physiology and digital technology. Now that we experience health and illness through so much technology (e.g. wearables, telemedicine, implanted devices), the medium is redefining our expression of symptoms, the observable signs of pathology and the range of diseases that may occur. Here, we systematically review all case reports describing illnesses related to digital technology in the past ten years, in order to identify novel biotechnological syndromes, map out new causal pathways of disease, and identify gaps in care that have disadvantaged a community of patients suffering from these digital complaints.MethodsPubMed, MEDLINE, Scopus, Cochrane Library and Web of Science were searched for case reports and case series that described patient cases involving biotechnological syndromes from 01/01/2012 to 01/02/2022. For inclusion the technology had to play a causative role in the disease process and had to be digital (as opposed to simple electronic).ResultsOur search returned 7742 articles, 1373 duplicates were removed, 671 met the criteria for full review and 372 were included in the results. Results were categorised by specialty, demonstrating that syndromes were most common in Cardiology (n = 162), Microbiology and Infectious Diseases (n = 36), and Emergency and Trauma (n = 26).DiscussionThe 372 unique patient cases demonstrated a range of severity from mild (e.g., injuries related to Pokemon Go) to moderate (e.g. pacemaker-generated rib fractures) and severe (e.g. ventilator software bugs causing cardiac arrest). Syndromes resulted from both consumer technology (e.g. gaming addictions) and medical technologies (e.g. errors in spinal stimulators). Cases occurred at both the individual level (e.g. faulty insulin pumps) and at the population level (e.g. harm from healthcare cyberattacks).LimitationsThis was a retrospective systematic review of heterogeneous reports which may only reflect a small proportion of true prevalence rates in the population.
Prediction of natural gas consumption in residential and commercial buildings; a case of 5 big cities located in the United States
Authors: Nematchoua Modeste Kameni
Published: May 2023

The aims of this study is to predict natural gas consumption and price in residential and commercial building into five big cities (California, Washington, New-York, Texas, and Florida) in the United States. Three different machine learning algorithms such as linear model (LM), Support Vector Machine regression (SVMR), and Random Forest regression (RFR) have been used. Four statistical tests (ANOVA, Chi-square, regression, and Minitab tests) have allowed to select among the eleven weather parameters those that affected significantly the performance of natural gas. Finally, after applied these four tests, only minimum, mean, maximum air temperature and mean air speed have been recognized as principal parameters having a direct impact on the natural gas consumption. To decide on the success of these algorithms, four different statistical metrics (Mean Absolute Error (MAE), Root Mean Squared Error (RMSE), Regression coefficient R², and mean square error (MSE)) were discussed in this study. The results showed that linear model and Random forest regression could be applied to predict the natural gas consumption with a good accuracy, despite this, Random Forest regression model is the best fitting model among all the three models used. It is followed by LMR, and SVMR, respectively.
Analysis of the effects of green infrastructure on flooding in Mexico City
Authors: Vargas Rafael , Torres Marco A. , Reinoso Eduardo
Published: May 2023

Expanding urbanization and imperviousness increase the frequency and severity of flooding in cities. Urban planners and decision-makers have implemented green infrastructure solutions in several cities to reduce the impact flooding. This research aims to investigate the effect of surface permeability and green infrastructure implementation on reducing stormwater flooding in Mexico City. First, we modelled the impact of stormwater flooding using the TR-55 methodology in Mexico City in the present condition, without GI. The model was used to identify the city districts with highest flood hazard. Moreover, a combination of scenarios was tested representing five stages of green infrastructure implementation, from 20% to 100% of all adequate areas, under 10, 25, 50, 100, and 500-years precipitation events. Specific criteria for selecting adequate areas for green infrastructure implementation were used. Open geographic data from was used in QGIS. In addition, the maps of estimated flood heights were classified in five hazard classes, from very low to very high. The results showed that implementing 100% of green infrastructure in the adequate areas, reduces the very high flood hazard an average of 12 km2 for five return periods. This study can serve as a reference to other cities to develop plans for green infrastructure implementations.
The Impact of the Urban Matrix on Arthropod Biodiversity and Ecosystem Services in Community Gardens
Authors: Kaiser Asia , Resasco Julian
Published: May 2023

As the number of humans living in cities increases, there is a growing interest in the value of community gardens to provide agricultural products to city dwellers in their own neighborhoods. However, neighborhoods with different land cover and socioeconomic characteristics often differ in their ecological attributes, leading to potential differences in biodiversity-mediated ecosystem services (i.e., pollination and pest control). The "luxury effect" is a documented phenomenon in urban ecology, showing that higher-income neighborhoods have greater biodiversity. Here we ask, how do the landscape and socioecological features of the urban matrix around community gardens impact arthropod biodiversity and the ecosystem services it provides as measured through crop yield? We collected arthropods across community garden sites in Boulder Co., CO, and used experimental jalapeno pepper plants as a sentinel crop to measure herbivory damage and pollination services. Through structural equation modeling, we found that fruit size increased as a function of pollinator biodiversity, and, unexpectedly, pollinator biodiversity was negatively related to neighborhood wealth. Investing in interventions that maximize bee biodiversity in cities may increase equitable food access from community gardens.
Research on Cognitive Radio Spectrum Allocation Strategy Based on Machine Learning Algorithm and Data Science Technology
Authors: Li Xiaowu , Huang Tangsen , Xiao Huijun , Xiao Fuan
Published: May 2023

With the rapid development of wireless communication technology, radio technology has gradually come into people’s sight. The arrival of the information age also makes people more urgent to need radio technology. However, the allocation of traditional static wireless spectrum resources is extremely uneven, which leads to extreme scarcity of spectrum resources. Many authorized spectrum is idle and spectrum utilization is low. In order to improve the utilization of spectrum resources and make secondary use of idle spectrum, this paper studied the cognitive infinite agent Spectrum Allocation (SA) strategy based on Machine Learning (ML) algorithm and data science technology. This paper compared Cognitive Radio (CR) SA based on ML algorithm and data science technology with traditional methods. The experimental results showed that the average practicability of the two CR SA in the public mobile communication frequency band was 80% and 74% respectively; the average practicability in the terrestrial TV frequency band was 75% and 59.5% respectively. Therefore, CR SA based on ML algorithms and data science and technology could improve the practicability and resource utilization of spectrum.
Anatomical Variations in Living Donors for Liver Transplantation – Prevalence and Correlation
Authors: Khalid Abdullah , Saleem M. Asad , Haq Ihsan , Khan M. Yasir , Rashid Sohail , Dar Faisal Saud
Published: May 2023

Purpose:
Living donor liver transplantation (LDLT) is a widely accepted option to address the lack of a deceased liver program for transplantation. Understanding vascular and biliary anatomy and their variants is crucial for successful and safe graft harvesting. Anatomic variations are common, particularly in the right hepatic lobe. To provide evidence for screening potential liver transplant donors, the presence of vascular and biliary anatomic variations in the preoperative assessment of transplantation donor candidates in Pakistan were explored.
Methods:
The was a retrospective cross-sectional study to evaluate the hepatic artery, portal vein, hepatic vein, and biliary variations in living liver donors. The study included 400 living liver donors, and data was collected from March 2019 to March 2023. We used a CT scan and MRCP to assess the anatomical variations.
Results:
The study examined 400 liver donors aged 18 to 53 years. Conventional arterial anatomy was the most common (65.8%), followed by replaced right hepatic artery (16%) and replaced left hepatic artery (10.8%). Conventional type 1 biliary anatomy was seen in 65.8% of cases. The dominant right hepatic vein was found in 13.3% donors. There was a significant association between the prevalence of variant portal venous anatomy with variant biliary anatomy.
Conclusion:
There was high variability in hepatic venous anatomy and a similar prevalence of variant hepatic arterial anatomy to other studies. A strong relationship between variant portal venous and biliary anatomy was found. These findings can aid in selecting suitable candidates and improving surgical planning for liver transplantation.
Ribo-seq and RNA-seq analysis enrich the regulatory network of tomato fruit cracking
Authors: Zhong Zhaojiang , Wu Zhen , Zhou Rong , Yu Xiaowei , Zhou Yuanyuan , Zhai Yinghao , Lin Haowei , Jiang Fangling
Published: May 2023

Tomato (Solanum lycopersicum), one of the most widely grown vegetable crops in the world, faces cracking problems before and after harvest. Fruit cracking reduces the commercial value and seriously affects the economic performance of the fruits through affecting the appearance and quality of the fruit. Clarifying the molecular mechanism underlying tomato fruit cracking is of great importance for the selection and breeding of crack- resistantvarieties. At present, research on the molecular mechanism of tomato fruit cracking has made progress, but few studies have been conducted to explore the genes related to fruit cracking regulation using combined multi-omics analysis. We applied Ribo-seq (ribosome analysis sequencing) and RNA-seq (RNA-sequencing) techniques to uncover potential fruit cracking regulatory genes and improve the regulatory network of fruit cracking using extremely cracking-resistant (CR) and cracking-susceptible (CS) tomato genotypes. Combining these two sets of histological data and translation efficiency, 41 genes were identified to be associated with fruit cracking. The genes played functions on hormone synthesis (Solyc09g089580.4, Solyc07g049530.3, etc.), cell wall metabolism (Solyc04g071070.2, Solyc03g123630.4, etc.), mineral (Solyc10g006660.3, Solyc01g057770.3, etc.), while 10 of them were transcription factors (Solyc05g015850.4, Solyc08g078190.2, etc.).Based on the investigation of interaction relationship between these genes, the synergistic regulation of multi-gene tomato fruit cracking was predicted. Finally, uORFs (upstream open reading frame) in the 5’ UTR region, which may affect the translation efficiency of downstream mORFs (main open reading frame), were analyzed. This study suggests that the synergistic action of transcription and translation is an important molecular mechanism in regulating tomato fruit cracking.
Platelet/Albumin ratio and plateletcrit levels are potential new biomarkers for assessing endoscopic inflammatory bowel disease severity
Authors: Huang Jun , Lu Jie , Jiang Feiyu , Song# Tiejun
Published: May 2023

Purpose
Endoscopy is currently recognized as the gold standard for assessing inflammatory bowel disease (IBD) severity. However, because the procedure is costly and invasive, endoscopy is not suitable for frequently monitoring intestinal inflammation. In this study, our aim was to identify noninvasive, low cost, and convenient biomarkers for identifying endoscopic IBD activity.
Methods
In total, 246 patients with IBD (131 with ulcerative colitis (UC) and 115 with Crohn’s disease (CD)) and 369 healthy controls were recruited for this retrospective study. IBD activity was evaluated using endoscopic and clinical examinations. The potential of several inflammatory biomarkers, including platelets (PLT), plateletcrit (PCT), albumin (ALB), highly sensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and platelet-to-albumin ratio (PLT/ALB) to assess endoscopic IBD activity was evaluated using receiver operating characteristic (ROC) analyses.
Results
PLT/ALB ratio, PLT, ALB, and hs-CRP levels were correlated with Mayo scores in UC patients, while PCT, PLT, fibrinogen (FIB), PLT/ALB ratio, hs-CRP, and ESR levels were correlated with Simple Endoscopic Scores for CD (SES-CD) in CD patients. ROC analyses showed that the area under the curve (AUC) value for the PLT/ALB ratio (0.705) was greater than hs-CRP (0.607) and ESR (0.552) values in UC patients. The AUC value for PCT (0.779) was greater than hs-CRP (0.698) and ESR (0.746) values in CD patients.
Conclusion
PLT/ALB ratio and PCT biomarkers were the most appropriate of all tested inflammatory biomarkers for assessing endoscopic IBD activity in UC and CD patients, respectively.
Participation of Scheduled Caste Youth in achieving Sustainable Development Goals (SDGs) in Tamil Nadu: A Critical Analysis
Authors: Subramanian Lalitha , Roul Avilash , Natarajan Karpagam , Selvam Sona
Published: May 2023

For achieving the targets of the Sustainable Development Goals (SDGs) it is very much called for the meaningful participation of the youth. The young population in India is sizable, diversified, and affected by a wide range of problems. Due to their social status and caste rigidity, youth from Scheduled Castes (SC) are a vulnerable group. Despite numerous laws and programs, Tamil Nadu's programs designed for SC youth have a lower-than-average active participation rate. Their transition and social development are negatively impacted by poverty, unemployment, illiteracy, discrimination, and the lack of opportunities. Numerous empirical studies have examined at the status of SC in terms of their involvement in work and education, but none have yet studied at their involvement in accomplishing the SDGs. In relation to Goals 4 and 8, this paper examines how SC youth in Tamil Nadu participate in the SDGs. It then offers an inclusive strategy to increase SC youth participation in accomplishing the SDGs.
Polycaprolactone and acylated soy protein isolate to tune the features of brown seaweed biocomposites
Authors: Santana Ismael , Felix Manuel , Bengoechea Carlos
Published: May 2023

Invasive brown seaweed Rugulopteryx okamurae (RO) can be used as basis of biocomposites with different polymers, such as polycaprolactone (PCL) or acylated soy protein isolated (SPIa). The addition of PCL can strengthen the biocomposite and the elastic modulus (E') goes from ~ 110 MPa to ~ 250 MPa. Nevertheless, when SPIa is added, a softening takes place, leading to E’ values around 40 MPa. The addition of PCL or SPIa induces a greater deformability in the systems, with a maximum deformation (~ 2.25 or ~ 23%) for a 70/30 or 25/75 ratio, respectively. The presence of PCL reduces the absorption of water, while SPIa produces a substantial increase to the point of obtaining superabsorbent materials at a 25/75 ratio (~ 2450 wt.%). In conclusion, the adequacy of the seaweed materials for different applications can be modulated through the addition of an adequate filler.
Investigating years of life lost in Belgium, 2004– 2019: A comprehensive analysis using a probabilistic redistribution approach
Authors: Devleesschauwer Brecht , Scohy Aline , Pauw Robby , Gorasso Vanessa , Kongs Anne , Neirynck Elias , Verduyckt Peter , Wyper Grant M. A. , Borre Laura
Published: May 2023

Introduction
Information on years of life lost (YLL) due to premature mortality is instrumental to assess the fatal impact of disease and necessary for the calculation of Belgian disability-adjusted life years (DALYs). This study presents a novel method to reallocate causes of death data.
Materials and methods
Causes of death data are provided by Statistics Belgium (Statbel). First, the specific ICD-10 codes that define the underlying cause of death are mapped to the GBD cause list. Second, ill-defined deaths (IDDs) are redistributed to specific ICD-10 codes. A four-step probabilistic redistribution was developed to fit the Belgian context: redistribution using predefined ICD codes, redistribution using multiple causes of death data, internal redistribution, and redistribution to all causes. Finally, we used the GBD 2019 reference life table to calculate Standard Expected Years of Life Lost (SEYLL).
Results
In Belgium, between 2004 and 2019, IDDs increased from 31% to 34% of all deaths. The majority was redistributed using predefined ICD codes (14-15%), followed by the redistribution using multiple causes of death data (10–12%). The total number of SEYLL decreased from 1.83 to 1.73 million per year. In 2019, the top cause of SEYLL was lung cancer with a share of 8.5%, followed by ischemic heart disease (8.1%) and Alzheimer’s disease and other dementias (5.7%). All results are available in an online tool https://burden.sciensano.be/shiny/mortality2019/.
Conclusion
The redistribution process assigned a specific cause of death to all deaths in Belgium, making it possible to investigate the full mortality burden for the first time. A large number of estimates were produced to estimate SEYLL by age, sex, and region for a large number of causes of death and every year between 2004 and 2019. These estimates are important stepping stones for future investigations on Disability-Adjusted Life Years (DALYs) in Belgium.
In selective patients, chyme reinfusion via distal loop ileostomy reduced anastomotic leakage rate after excision of colonic fistula following severe acute pancreatitis
Authors: Chen Ke , Xu Xin , Zhao Risheng , Luo Shikun , Tian Weiliang , Yang Fan , Yao Zheng
Published: May 2023

Purpose
This study aimed to investigate effect of chyme reinfusion (CR) via distal loop ileostomy, in selective patients with pancreatitis cure, on the reduction of anastomotic leakage rate after excision of colonic fistula following severe acute pancreatitis (SAP)
Methods
From January 2009 to May 2021, patients who were suitable for CR via distal loop ileostomy and underwent excision of colonic fistula following SAP were considered to be eligible. Patients were selected and considered suitable for CR if the following conditions were met: (1) SAP cured; (2) no colon obstruction; (3) colonic fistula drainage tube was in place; and (4) no pus cavity was around the fistula and the sinus mature. Before 2014, CR was not used, whereas it was widely used after 2014 in selected patients. Patients were divided into the CR group and non-CR group according to whether CR was performed. The effect of CR on reduction of postoperative anastomotic leakage were then investigated.
Results
Eighty-five patients were enrolled in the study. There were 40 patients in the non-CR group and 45 patients in the CR group, with a total of 28 (32.9%) patients with anastomotic leakage. CR (OR = 0.48; 95% CI: 0.24–0.95; p = 0.036) reduced the incidence of anastomotic leakage. In addition, CR (HR = 0.51; 95% CI: 0.27–0.86, p = 0.012) was shown to reduce the incidence of postoperative ileus.
Conclusion
In selected patients with pancreatitis cure, CR via distal loop ileostomy for colonic fistula following SAP reduced the anastomotic leakage rate.
A diagnostic framework linking eddy flux ellipse with eddy-mean energy exchange
Authors: Yang Yi , Chen Ru , Flierl Glenn R. , Zhang Hong
Published: May 2023

The performance of non-eddy-resolving numerical models requires a good understanding, with appropriate representation, of eddy-mean flow feedbacks. To help improve our understanding of these feedbacks, we propose here a diagnostic framework \textcolor{black}{that links eddy geometry to the eddy-mean energy exchange terms from the Lorenz energy diagram}. In particular, this framework provides explicit mathematical formulas that link eddy-mean energy exchange rates with both mean state structure and the properties of eddy momentum/buoyancy ellipses. Complimenting previous works that interpret the mean flow shear cases (e.g., ${\partial \overline{u}}/{\partial y}$ and ${\partial \overline{u}}/{\partial z}$) using eddy geometry, this framework also gives a geometric interpretation of the horizontal normal strain component (e.g., ${\partial \overline{u}}/{\partial x}$) of eddy-mean kinetic energy exchange rates ($M_{K_E}$). To test this framework, we use the ECCO2 (Estimating the Circulation and Climate of the Ocean, phase 2) state estimate. In the ECCO2 state estimate, the horizontal normal strain component of the globally integrated $M_{K_E}$ has a magnitude comparable to that of the shear strain component. Regional application of this framework shows that the quasi-meridional orientation of eddy momentum ellipses in the downstream Kuroshio Extension is consistent with the dominance of the horizontal normal strain component of $M_{K_E}$ there. Our key findings \textcolor{black}{also hold} in a submesoscale-permitting model. This framework offers a tool for interpreting eddy-mean energy exchange and eddy ellipse patterns. It may also offer guidance for the parameterizations of eddy stress and eddy-mean flow feedbacks.
Quantitative Evaluation of Plants on the Top Surface of the Great Wall in Dazhuangke Using the Analytical Hierarchy Process——based on the protective repairs of the Great Wall
Authors: Pan Jianbin , Xu Nuo , Tang Yuyang , Cheng Meijing , Zhang Lin , Lan Jingwen
Published: May 2023

The Great Wall is a world-renowned cultural heritage site. The plants growing on top surface of the Great Wall endanger the safety of the Great Wall structure, but the process of removing them may further damage the body of the Great Wall. In this paper, based on Analytic Hierarchy Process and expert consultation, we selected 13 specific index from three constraint layer factors, and then estimated and identified 45 species/categories of plants on top surface of the Dazhuangke section of the Great Wall. The results show that the evaluation grade of the plants, and the factor of Disruptive Effects (Constraint layer) is the core element of the evaluation model, and the index of Impact on the near side wall and top surface of great wall (Standard Layer) plays the main guidance role in the evaluation system. This research provides scientific basis for the protection of cultural landscape of the Great Wall.
Association of gene polymorphisms in ACTA2, MYH11, FBN1 and TGF-β signaling with the susceptibility of DeBakey type III aortic dissection
Authors: Zhou Chengming , Zhao Hongwei , Jiang Peipei , Sun Ling , Chang Yafei , Ma Xiang , Du Zhi-Min , Yuan qinghua
Published: May 2023

Object: To evaluate the contribution of actin alpha 2, smooth muscle (ACTA2), myosin heavy chain protein 11 (MYH11), fibrillin 1(FBN1) and transforming growth factor β signaling-related gene polymorphisms and gene-environment interplay in DeBakey type III aortic dissection (AD).
Methods: Twelve single-nucleotide polymorphisms (SNPs) (rs115364997 and rs117593370 of MYH11, rs11070646, rs145233125 and rs201170905 of FBN1, rs2028493, rs2119685 and rs3781211 of ACTA2, rs1800469 of TGFB1, rs1626340 of TGFBR1, rs900 of TGFB2, rs4522809 of TGFBR2) were analyzed in patients with DeBakey III AD (159) and non-AD controls (390). Generalized multifactor dimensionality reduction (GMDR) was used to assess gene-gene and gene-environment interactions.
Results: MYH11 rs115364997 dominant model AG+GG/AA genotype, TGFBR1 rs1626340 dominant model GA+AA/GG genotype and FBN1 rs201170905 dominant model GG+AG genotype and recessive model GG genotype were identified to be associated with AD risk. Also, the TGFB1 rs1800649 G carrier had an increased AD risk. Two SNPs (rs2119685 and rs3781211) located in ACTA2 were also associated with the susceptibility of AD in the dominant model. The gene-gene interaction of FBN1 rs201170905, ACTA2 rs3781211, TGFB1 rs1800469, TGFBR1rs1626340, TGFB2rs900, TGFBR2rs4522809 was identified as the best model([CVC]) 10/10; p =0.0107). The interaction of gene-gene and gene-environment are associated with the risk of DeBakey type III AD.
Role of macrophages in peripheral nervous system involvement in patient with primary Sjogren’s syndrome
Authors: Zheng Jiaman , Zhang Jiayu , Xu Liying , Li Ziqi , Ye Huihao , Yang Min , Yuan Chao
Published: May 2023

Aims: To explore the role of macrophage in peripheral nervous system involvement in patients with primary Sjogren’s syndrome.
Methods and Results:Methods: Sural nerve biopsy was performed in 12 patients diagnosed with primary Sjogren’s syndrome associated peripheral nervous system involvement (pSS-PN). The structural features of sural nerve stained by hematoxylin-eosin(HE) under light microscope. Immunohistochemistry and immunofluorescence staining were carried out to detect the distribution and polarization of macrophage in peripheral neuropathy, using CD206 and iNOS antibodies to label different types of macrophage. The ultrastructural changes of macrophage and peripheral nerves in pSS-PN were observed by transmission electron microscopy. Results: Sural nerve biopsies were performed in 12 patients with pSS-PN, including four men and eight women whose age was 50.4±16.3 years (means±SD) and the duration was 4.43±4.06 months (means±SD). HE staining showed different degrees of reduction of large and small myelinated fibers, NF staining showed various reduction of non-myelinated fibers (mild in 4 cases, moderate in 5 cases, and severe in 3 cases). Immunohistochemistry revealed that inflammatory cell infiltrated in nerve tracts and around blood vessels in 8 cases, and the remaining four patients presented with mixed peripheral neuropathy, mainly axonal damage. Immunofluorescence also revealed that CD68+ macrophages infiltrated in the small vessels and nerve bundles, and M2 macrophages were the main type. Ultrastructure enlarged by electron microscopy showed infiltration of macrophages around nerve fibers, which engulf nerve myelin and axons. In the early stage we can see local swelling and enlarged of axons, then atrophy of axons, and finally separation of axon membrane from myelin, small axis mutation, and loss of normal proportion to myelin.
Conclusions: Macrophages play an important role in Sjogren's syndrome related peripheral neuropathy, and are involved in the occurrence of vasculitis, demyelination and axonal damage.
Interseismic slip distribution and locking characteristics of the mid-southern segment of the Tanlu fault zone
Authors: YU SHUYUAN , LIU ZHUMEI , LIU ZEMIN , LI LAYUE , ZU LIANGYU , YANG YUANYUAN , LUO JIAJI
Published: May 2023

The central and southern sections of the Tanlu fault zone experience frequent seismic activity and have a dense population distribution. Infrastructure, such as high-speed rail and the South–North Water Diversion project, as well as world heritage sites, such as the Grand Canal, ancient city ruins, and cultural landscapes, is located along the fault. A strong earthquake occurring in the future may cause significant social impacts and property losses. It is necessary to clearly understand the current activity characteristics and potential seismic risk of the fault zone to scientifically and reasonably reduce the losses of earthquake disasters. However, there are little data on its current activity through geodetic data. Based on GPS observation data from 1991 to 2018, the fine slip distribution characteristics between present earthquakes in the mid–southern segment of the Tanlu fault zone were retrieved based on the fastest descent method. On this basis, the lock degree and slip rate deficit characteristics of this section were obtained. The differences in the deformation characteristics between the two phases of the mid–southern segment of the Tanlu fault zone were analysed by comparing the surface strain results from 1991 to 2007 and 2013 to 2018. The results show that the interseismic sliding rate of the mid–southern segment of the Tanlu fault zone was 0–1 mm·a-1. The northern Tancheng–Sihong section showed right-handed thrust, and the sliding rate was 0.2–1 mm·a-1. The southern Sihong–Tongcheng section was stretched left–right, and the sliding rate was 0–0.5 mm.a-1 The degree of blockage in the mid–southern segment of the Tanlu fault zone was segmented along the fault strike. In the northern section, the locking depth of the Changyi–Tancheng section was relatively high, with the deepest reaching 32 km, and the maximum compression-slide loss rate reached -1 mm·a-1; the Tancheng–Wangji closure coefficient decreased significantly, with a concentrated distribution between 0.2 and 0.7. The Wangji–Jiashan section has a high degree of closure, small and medium earthquakes are not active, and it is the unruptured section, being more prone to stress accumulation.
Altered Proinflammatory Cytokine Response in Colorectal Cancer Patients: Insights into Immune Dysregulation
Authors: Shakhpazyan Nikolay , Mikhaleva Liudmila , Bedzhanyan Arkady , Sadykhov Nikolay , Midiber Konstantin , Orekhov Alexander
Published: May 2023

Colorectal cancer (CRC) is a significant global health concern and is the third most common cancer worldwide. The interplay between the tumor microenvironment, immune system, and inflammation is critical in CRC development and progression. Pro-inflammatory cytokines, TNF-alpha and IL-1beta, play distinct and contrasting roles in CRC and modulate inflammation in the tumor microenvironment. This study enrolled 12 patients with newly diagnosed colorectal cancer and 9 age- and sex-matched control subjects. Monocyte cultures were obtained from patient blood samples using CD14 + cell isolation and performed Double LPS Stimulation Assay. TNF-alpha and IL-1beta concentrations were measured using ELISA. Our results showed that TNF-α secretion by monocytes in CRC patients became exhausted following the first LPS stimulation, with significantly lower levels after 7 days and no increase after re-stimulation. The secretion of IL-1beta had higher levels in the non-stimulated culture of CRC patients and more pronounced secretion after LPS re-stimulation. These findings suggest an altered pro-inflammatory cytokine response in CRC patients, which could contribute to the tumor microenvironment and inflammatory processes associated with CRC progression. These results provide valuable insights into potential therapeutic targets for modulating the immune response in CRC patients.
CLOCK 3111 T/C SNP Interacts with evening preference, appetite hormones, late eating and sleep reduction for obesity and food intake in obese Iranian adults
Authors: Rahati Sara , Qorbani Mostafa , Naghavi Anoosh , Pishva Hamideh
Published: May 2023

Background
Previous studies have shown that the Circadian locomotor output cycles protein kaput (CLOCK) gene (rs1801260) variant may be associated with obesity risk. Moreover, lifestyle and biochemical parameters have been shown to elicit favorable effects on the obesity risk potentially. Therefore, this study seeks to investigate the effect of lifestyle, biochemical parameters, and CLOCK interaction on food intake and risk of obesity.
Methods
This cross-sectional study comprised 403 overweight and/or obese subjects aged 20–50 from Iran. The CLOCK rs1801260 data was measured by the PCR-RFLP method. Dietary intake, food timing, sleep duration, appetite, and chronotype were assessed by using validated questionnaires. Ghrelin and Glucagon-like peptide-1 (GLP-1) were measured by radioimmunoassay in plasma samples. Participants were also divided into three groups based on rs1801260 genotype. Univariate linear regression models were used to assess the interaction between CLOCK and study parameters on body weight, and logistic regression models were used for interaction terms between CLOCK and study parameters on food intakes.
Results
After controlling confounding factors, our findings showed significant interactions between the C-allele carrier group with chronotype (Pinteraction = 0.048), appetite (Pinteraction = 0.035), lunch time (Pinteraction = 0.016), dinner time (Pinteraction = 0.047), GLP-1 (Pinteraction = 0.035), and ghrelin (Pinteraction = 0.022) on obesity. Also, there was a significant interaction between evening type, high appetite, short sleep and late lunch with C-allele on food intake.
Conclusion
The results of the present study indicate that differences in sleep, appetite hormones, eating behaviors and chronotype influence the risk of obesity differently by CLOCK genotype. These results highlight that diet, gene variants, lifestyle factors, and their interaction should be considered in obesity risk assessment.
WITHDRAWN: Facilitating Positive Outcomes through DREAM Presence Practice Guidelines in Mental Health Nursing
Authors: Chukwuere Precious
Published: May 2023

Background
Mental health nurses are fundamental in facilitating presence for positive nurse and patient outcomes. Presence is a fundamental component of nursing care that focuses on providing comfort, support, and compassion to patients.
Objective
The objective of this study is to facilitate a workshop series on DREAM presence practice guideline (Dedication, Respect through Relationship, Environment, Art of Nursing, and Motivation) due to the dire need for presence practice to improve quality nurse and patient outcomes in South Africa.
Method
As part of a large pre-test and post-test research, a workshop series was organized with nurses caring for adolescents with various mental health illnesses in the two major psychiatric hospitals in the North West Province, South Africa. Access was granted to the study areas after the researchers obtained approval from the Health Research Ethics Committee, North West University (HREC- Reference Number: NWU-00009-22-A1), South Africa, and the North West Province Department of Health (DoH) and the various study areas. Three workshops were conducted in three separate weeks with nurses as frontline health care providers for adolescents with mental illnesses to educate them on DREAM presence practice guidelines.
Results
The study revealed a comprehensive understanding and appreciation of DREAM presence practice guideline by the mental health nurses. Further revealed that mental health nurses want to care and be there for their patients, but they are constrained by various factors such as understaffing, lack of adequate support, poor working conditions, and lack of available resources. Due to the challenges associated with managing adolescents with mental illnesses and the need for presence practice to improve nurse and patient outcomes, there is a dire need to support the nurses working in these wards including adequate psychosocial support, staffing, and funding of the wards to enable nurses to effectively practice presence, which is crucial in achieving positive outcomes. Generally, the study revealed that DREAM presence practice guideline could be the missing link in facilitating quality care in the management of adolescents with mental health illnesses. Participants suggested that mental health nurses setting boundaries during care, watching out for patients’ body language, being patient with the patients, and being open-minded will facilitate DREAM presence practice in the management of adolescents with mental illnesses.
Development and validation of a clinical prognostic model for BRAF V600E mutated colorectal cancer patients based on pathological stage, microsatellite status, and primary tumor site.
Authors: Ou Kai , Liu Xiu , Ma Xiaoting , Yang Lin
Published: May 2023

Objective
To develop and validate a prognostic model for patients with BRAF V600E-mutated colorectal cancer.
Methods
The clinical and pathological information of 206 patients with BRAF V600E mutated colorectal cancer diagnosed in Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College from 2014 to 2021 was retrospectively collected. LASSO regression, COX regression and Nomograms were used to develop clinical prognostic models. The differentiation was measured by C-statistic and the predicted variability was evaluated by calibration curve. The prognostic model was externally validated with validation set data from 164 patients pooled from 5 studies.
Results
Our clinical prognostic model included three variables: pathological stage, microsatellite status, and primary tumor site. In internal validation, the model had a concordant index of 0.785 (95%CI [0.732–0.839]) and a concordant index of 0.754 (95%CI [0.698–0.810]) using pathological staging. External validation confirmed the robustness of the model with a consistency index of 0.670 (95%CI ([0.617–0.724]) and a consistency index of 0.584 (95%CI [0.546–0.622]) using pathological staging. The calibration graph drawn based on the prediction and the actual situation is close to the 45° diagonal.
Conclusion
By adding microsatellite status and primary tumor site on the basis of pathological stage, we improved the discriminability and prediction accuracy of the model, and successfully established a prognosis model for patients with BRAF V600E mutation of colorectal cancer.
UV-Rays induced Cytomorphological and biochemical variations in Stevia rebaudiana Bertoni
Authors: Kumar Girjesh , Tiwari Naveen Kumar , Pandey Satya , Pandey Priyanka , Yadav Jyoti
Published: May 2023

Stevia rebaudiana Bertoni is a perennial herb of the Asteraceae family and is highly medicinal in number of ways. Abiotic stress such as UV radiation exposure was reported to have a beneficial effect on morphological traits of the plant. Plantlets of Stevia (4–5 cm) were exposedto UV-B rays with differential timeviz. 20, 40, 60, 80, and 100 minutes, respectively along withthe control set. The exposed plantlets were transferred to the greenhouse for further study and growth. After 45 days of plantation, morphological studies were taken out and tabulated. At intermediate doses i.e., 40 and 60 min, an increase in leaf area, leaf width, leaf length, plant height, internodal length and width of stem have been found in relation to morphological traits while in case of cytological study different chromosomal arrangements were observed viz. scattering, precocious movement, stickiness, unorientation and bridge formation,etc. Hence on the basis of morphological and cytological studies performed on Stevia afterUV irradiation,it was concluded that, shorter exposure of UV-B(40 and 60 min)induced some better morphological traits so that the qualitative and quantitative features of the plant were enhanced.
An efficient synthesis of phosphonated cyclopentenones by NaN 3 -catalyzed three-component reaction between trialkyl phosphites, ethyl arylmethylidenecyanoacetates and dialkyl acetylenedicarboxylates
Authors: Derranjia Akram Ranjbar , Anary-Abbasinejad Mohammad
Published: May 2023

NaN3-catalysed three-component reaction between trialkyl phosphites, dialkyl acetylenedicarboxylates and ethyl arylmethylidenecyanoacetates afforded phosphonated cyclopentenone derivatives. The process involves one C-P and two C-C bond formations in one synthetic step. All reactions were conducted in acetone as solvent at room temperature and the products were obtained in high yields as stable solids. The products were isolated and purified by simple washing with water and diethyl ether without need to tedious chromatography methods. The structures of products were proved by 1H, 13C and 31P NMR and IR spectral and elemental analysis data.
Risk Prediction of Second Primary Malignancies in Patients after Rectal Cancer: Analysis Based on SEER Program
Authors: Sun Yong-Chao , Zhao Zi-Dan , Fu Yue , Jiao Yu-Wen , Zhang Jia-Wen , Shi Wei-Hai
Published: May 2023

Background This study will focus on exploring the clinical characteristics of rectal cancer (RC) patients with SPMs and constructing a prognostic nomogram to provide clinical treatment decisions.Methods We determined the association between risk factors and overall survival (OS) while establishing a nomogram to forecast the further OS status of these patients via Cox regression analysis. Finally, we evaluated the performance of the prognostic nomogram to predict further OS status.Results Nine parameters were identified to establish the prognostic nomogram in this study, and, the C-index of the training set and validation set was 0.691 (95%CI, 0.662–0.720) and 0.731 (95%CI, 0.676–0.786), respectively.Conclusions We systematically explored the clinical characteristics of SPMs after RC and constructed a satisfactory nomogram.
Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation
Authors: Okolo Chidinma A. , Khaing Ei-Phyo , Mereacre Valeria , Munro Michelle L , Erickson Jeffery R , Jones Peter P.
Published: May 2023

Background
O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions. We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathological Ca2+ leak through the cardiac ryanodine receptor (RyR2) via Ca2+/calmodulin-dependent kinase II (CaMKII). However, RyR2 is well known to be directly regulated by other forms of serine and threonine modification, therefore, this study aimed to determine whether RyR2 is directly modified by O-GlcNAcylation and if this also alters the function of RyR2 and Ca2+ leak.
Methods
O-GlcNAcylation of RyR2 in diabetic human and animal hearts was determined using western blotting. O-GlcNAcylation of RyR2 was pharmacologically controlled and the propensity for Ca2+ leak was determined using single cell imaging. The site of O-GlcNAcylation within RyR2 was determined using site-directed mutagenesis of RyR2.
Results
We found that RyR2 is modified by O-GlcNAcylation in human, animal and HEK293 cell models. Under hyperglycaemic conditions O-GlcNAcylation was associated with an increase in Ca2+ leak through RyR2 which persisted after CaMKII inhibition. Conversion of serine-2808 to alanine prevented an O-GlcNAcylation induced increase in Ca2+ leak.
Conclusions
These data suggest that the function of RyR2 can be directly regulated by O-GlcNAcylation and requires the presence of serine-2808.
Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression
Authors: Ito Chihiro , Haraguchi Ryuma , Ogawa Kohei , Iwata Miku , Kitazawa Riko , Takada Yasutsugu , Kitazawa Sohei
Published: May 2023

The liver is known to possess remarkable regenerative potential, but persistent inflammation or severe acute injury can lead to liver fibrosis and incomplete regeneration, ultimately resulting in liver failure. Recent studies have shown that the axis of two types of CXCL12 receptors, CXCR4 and CXCR7, plays a crucial role in liver fibrosis and regeneration. The present study is aimed at investigating the regulatory factors involved in CXCR4 expression in injured liver. Immunohistochemical screening of liver tissue samples collected during liver transplantation revealed a reciprocal expression pattern between CXCR4 and MeCP2. An in vitro system involving cultured cell lines and H2O2 treatment was established to study the impact of oxidative stress on signaling pathways and epigenetic alterations that affect CXCR4 mRNA expression. Operating through distinct signaling pathways, H2O2 treatment induced a dose-dependent increase in CXCR4 expression in both hepatocyte- and intrahepatic cholangiocyte-derived cells. Treatment of the cells with trichostatin and azacytidine modulated CXCR4 expression in hepatocytes by modifying the methylation status of CpG dinucleotides located in a pair of TA repeats adjacent to the TATA-box of the CXCR4 gene promoter. Only MeCP2 bound to oligonucleotides representing the TATA-box region when the cytosine residues within the sequence were methylated, as revealed by Electrophoretic Mobility Shift Assay (EMSA). Methylation-specific PCR analysis of microdissected samples revealed a correlation between the loss of CpG methylation and the upregulation of CXCR4 in injured hepatocytes, replicating the findings from the in vitro study. Besides the conventional MEK/ERK and NF-κB signaling pathways that activate CXCR4 in intrahepatic cholangiocytes, the unique epigenetic modifications observed in hepatocytes might also contribute to a shift in the CXCR4-CXCR7 balance towards CXCR4, leading to irreversible liver injury and fibrosis. This study highlights the importance of epigenetic modifications in regulating CXCR4 expression in liver injury and fibrosis.
The Discrete Rational Cubic Spline With Consant Shape Parameter
Authors: YPDUBEY  , Tiwari Jotty
Published: May 2023

In this paper, the problems of Shape Preserving Discrete C2 Rational Cubic Spline(Cubic /Quadratic) has been proposed, positive preserving and Error bound obtained. The Discrete Rational Method have unique representation.
Historia y ficción: una nueva alianza
Authors: Dosse François
Published: May 2023

Los años estructuralistas de la década de 1960 estuvieron marcados en Francia por el deseo de una escritura intransitiva, de espaldas a la sociedad, en nombre de una escritura blanca, intransitiva, como decía Roland Barthes, aislada de la realidad, del referente. Hoy, sin embargo, asistimos a un "retorno" de la ficción, de la novela al mundo social. Podría pensarse que se trata de una vuelta al siglo XIX, al realismo de un Balzac o un Zola, pero en realidad este nuevo acercamiento a lo social se nutre de las aportaciones de la lingüística, la sociología, el psicoanálisis y la historia. La actualidad está marcada por la opacificación del futuro, del proyecto, y recae en el presentismo. La consecuencia de este presentismo es modificar fundamentalmente nuestra relación con el pasado, que ya no corresponde a uno de los elementos que conducen al futuro, sino que se vuelve melancólico, nostálgico, patrimonial, a falta de un proyecto hacia un futuro.
Adolescent Responses to the Social Campaign Video on Kemdikbud.RI Account about Cyber-sexual Harassment
Authors: Rumahorbo Karinda Amilia , Mutiaz Intan
Published: May 2023

The primary purpose of a social campaign is to change a person's behavior or attitude regarding some social issues under the message conveyed by the communicator. It is described as persuasive communication. Furthermore, this study aimed to analyze the video content of the #GerakBersama social campaign from the cerdasberkarakter.kemdikbud.ri account about cyber sexual harassment and the audience's responses to the campaign related to awareness of this new phenomenon on social media. This study used mixed methods with data collection through in-depth interviews and surveys to obtain a thorough understanding from audiences and advertising experts regarding video advertising messages. The authors used Aristotle's theory of persuasion communication with three main pillars, namely ethos, pathos, logos, and the AISAS communication model to analyze the responses of the campaign video. These theories were processed and modified to obtain conclusions about the target audience's response to social advertisement videos regarding cyber-sexual harassment and to identify persuasive communication strategies in social campaigns as a reference for advertising professionals and academics in responding to new social problems in online media. The study results were also expected to reference further communication strategies and understanding related to persuasive communication in advertising and social campaigns.