bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Process Parameters in Electrochemical Micromachining of AMCs by Using Different Techniques of Weight Evaluation
Authors: Maniraj S. , Thanigaivelan R. , Gunasekaran K. , Saravanan K. G.
Published: February 2023

The application of electrode heating is proposed in electrochemical micromachining (EMM). In the EMM process, the temperature of the electrode, voltage, duty cycle, and electrolyte concentration are considered process parameters. Taguchi L18 mixed-level orthogonal array (OA) design was adopted for designing the experiments and this study highlights the effect of temperature on responses such as radial overcut (ROC), material removal rate (MRR), and conicity factor (CF). In addition, multicriterion design making (MCDM) with VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje, i.e., multi-criteria optimization and compromise solution) technique is used for finding the best alternatives based on the distinct weight assessing methods such as equal weights method (EWM), analytic hierarchy process (AHP), and entropy-based weights method (EBWM). Furthermore, a confirmation test is also conducted to find the best optimal parameters and their levels among the EWM-VIKOR, AHP-VIKOR, and EBWM-VIKOR. The results revealed that AHP-VIKOR provides a maximum improvement of 0.945 among the three methods.
The Correlation between Altmetric Attention Score and Traditional Bibliometrics in Top Nursing Journal Articles
Authors: Chen Lingmin , Yang Mutong , Li Nian , He Ying , Zhang Yonggang
Published: February 2023

Background. Altmetric Attention Score (AAS) is a quantitative measurement of the online impact of research and has a potential correlation with traditional bibliometrics. However, the correlation for nursing journal articles is still unknown. The objective of the study was to analyze the correlation between AAS and traditional bibliometrics in the top nursing journal articles. Materials and Methods. Articles published in top nursing journals (the journals with the top 20 5-year impact factors) from 2010 to 2019 were included. The correlations between AAS and citations, AAS and Relative Citation Ratio (RCR) score, AAS and Category Normalized Citation Impact (CNCI) value, and AAS and impact factors were analyzed. Statistical analyses were performed using Stata 25.0 software. Results. A total of 15,212 journal articles were included in the study. Very weak correlations were found between AASs and citations [0.124 (95% CI, 0.108–0.14)], AASs and RCRs [0.26 (95% CI, 0.244–0.275)], and AASs and CNCIs [0.207 (95% CI, 0.192–0.223)]. The weak correlations were also found between AASs and impact factors in several journals. The weak correlations between AASs and citations, AASs and CNCIs, and AASs and RCRs were also found for most journals based on subgroup analysis. Conclusions. There is very weak correlations between AASs and traditional bibliometrics in top nursing journal articles. More studies should be conducted to assess how AAS influence bibliometrics, and how they can help manage nursing journal articles and research.
Design of Particle Swarm Optimization Adaptive Sliding Mode Controller Based on an Extended State Observer for the Longitudinal Motion of a Supercavitating Vehicle with Input Saturation
Authors: Yang Guang , Lu Faxing , Wu Ling , Xu Junfei
Published: February 2023

The aim of this paper is to present a novel sliding mode control scheme for the supercavitating vehicle trajectory tracking problem that subjects to external disturbances and actuator saturation with two symmetric elevators and a cavitator as actuators by analytical methods and computer simulations. Firstly, the nonlinear and highly coupled dynamic and kinematic models of a supercavitating vehicle are presented in a comprehensive way by taking the cavity memory effect and time‐variant planing force into consideration. The PSO algorithm is employed to optimize the control parameters for achieving better and more practical tracking performance by minimizing the objective function. A second‐order extended state observer (ESO) is utilized to estimate the unknown external and state‐dependent disturbances and compensates for control inputs. In addition, an antiwindup compensator is adopted to cope with actuator saturation. Finally, the proposed control scheme is employed for complex trajectory tracking of a supercavitating vehicle under various conditions by conducting comparative numerical simulations. Rigorous theoretical analysis and simulation results indicate that the proposed control scheme can achieve satisfactory tracking performance and have a good capability of robustness.
A Deep Neural Network-Based Approach to Media Hotspot Discovery
Authors: Luo Pan
Published: February 2023

In recent years, with the rapid development of social network media, it has become a valuable research direction to quickly analyze these texts and find out the current hotspots from them in real time. To address this problem, this paper proposes a method to discover current hotspots by combining deep neural networks with text data. First, the text data features are extracted based on the graphical convolutional neural network, and the temporal correlation of numerical information is modeled using gated recurrent units, and the numerical feature vectors are fused with the text feature vectors. Then, the K-means algorithm is optimized for the initial point selection problem, and a clustering algorithm based on the maximum density selection method in the moving range is proposed. Finally, the text feature representation method based on graph convolutional neural network is combined with the clustering algorithm based on the moving range density maximum selection method to build a deep learning-based media hotspot discovery framework. The accuracy of the proposed media hotspot discovery method and the comprehensive evaluation of the computing time have been verified experimentally.
Toward High Capacity and Robust JPEG Steganography Based on Adversarial Training
Authors: Yang Jianhua , Shang Fei , Liao Yi , Chen Yifang
Published: February 2023

JPEG steganography has become a research hotspot in the field of information hiding. However, the capacity of conventional JPEG steganography methods is hard to meet the requirements in high-capacity application scenarios and also can not extract secret messages accurately after JPEG compression. To mitigate these problems, we propose a high-capacity and robust JPEG steganography based on adversarial training called HRJS, which implements an end-to-end framework in the JPEG domain for the first time. The encoder is responsible for embedding the secret message while the decoder can reconstruct the original secret message. To enhance robustness, an attack module forces the neural network to automatically learn how to correctly recover the secret message after an attack. Experimental results show that our method achieves near 100

%

decoding accuracy against JPEG_50 compression at 1/3 bits per channel (bpc) payload while preserving the imperceptibility of the stego image. Compared with conventional JPEG steganography methods, the proposed method is feasible with high capacity (e.g., 1 bpc) and has an obvious advantage in terms of robustness against JPEG compression at the same time.
Minimal Change Nephrotic Syndrome with Acute Kidney Injury after the Administration of Pfizer-BioNTech COVID-19 Vaccine
Authors: Gulumsek Erdinc , Ozturk Dilan Damla , Ozturk Huseyin Ali , Saler Tayyibe , Erdogan Kivilcim Eren , Bashir Ahmed Muhammad , Sumbul Hilmi Erdem
Published: February 2023

Nephrotic syndrome progresses with various metabolic disturbances, such as proteinuria over 3.5 grams in 24 hours, hypoalbuminemia, and hypercoagulability. Patients usually complain about diffuse edema throughout the body, which is secondary to hypoalbuminemia. It has many primary and secondary causes. Patients may require a renal biopsy to confirm the diagnosis. Besides, many secondary causes of nephrotic syndrome should be examined and excluded. Although many vaccines were developed due to the COVID-19, many side effects are still reported because of the Pfizer-BioNTech COVID-19 vaccine (COVID-19 mRNA and BNT162b2), which is widely used in Turkey. This study examines a case of nephrotic syndrome with acute renal injury after Pfizer-BioNTech vaccine.
Novel Gene Signatures Promote Epithelial-Mesenchymal Transition (EMT) in Glucose Deprivation-Based Microenvironment to Predict Recurrence‐Free Survival in Hepatocellular Carcinoma
Authors: Huang Yuan , Li Shi-Rong , Gao Ying-Jie , Zhu Yan-hua , Zhang Xiao-feng
Published: February 2023

Background. Current research studies have suggested that glucose deprivation (GD)-based tumor microenvironment (TME) can promote epithelial-mesenchymal transition (EMT) of tumor cells, leading to tumor invasion and metastasis. However, no one has yet studied detailedly the synthetic studies that include GD features in TME with EMT status. In our research, we comprehensively developed and validated a robust signature regarding GD and EMT status to provide prognostic value for patients with liver cancer. Methods. GD and EMT status were estimated with transcriptomic profiles based on WGCNA and t-SNE algorithms. Two cohorts of training (TCGA_LIHC) and validation (GSE76427) datasets were analyzed with the Cox regression and logistic regression analyses. We identified a 2-mRNA signature to establish a GD-EMT-based gene risk model for the prediction of HCC relapse. Results. Patients with significant GD-EMT status were divided into two subgroups: GDlow/EMTlow and GDhigh/EMThigh, with the latter having significantly worse recurrence-free survival (

P
<
0.01

). We employed the least absolute shrinkage and selection operator (LASSO) technique as a method for HNF4A and SLC2A4 filtering and constructing a risk score for risk stratification. In the multivariate analysis, this risk score predicted recurrence-free survival (RFS) in both the discovery and validation cohorts and remained valid in patients stratified by TNM stage and age at diagnosis. The nomogram that combines risk score and TNM stage as well as age produces improved performance and net benefits in the analysis of calibration and decision curves in training and validation groups. Conclusions. The GD-EMT-based signature predictive model may provide a prognosis classifier for HCC patients with a high risk of postoperative recurrence to decrease the relapse rate.
A Survival Model Based on the ASB Genes and Used to Predict the Prognosis of Kidney Renal Clear Cell Carcinoma
Authors: Xie Deqian , Dai Lu , Yang Xiaolei , Huang Tao , Zheng Wei
Published: February 2023

Kidney renal clear cell carcinoma (KIRC) is increasing in incidence worldwide, with poor and unpredictable patient prognosis limited by diagnostic and therapeutic approaches. New genes are urgently needed to improve this situation. The ankyrin repeat and suppressor of the cytokine signaling (SOCS) box (ASB) family are a promising class of tumorigenesis-related genes. We examined the expression and mutation of 18 ASB genes in various tumors for this study. The findings revealed that ASB genes exhibit significant copy number variation (CNV) and single nucleotide variation (SNV). There were substantial variations in ASB gene expression in different tumor tissues, and different levels of methylation of ASB genes affected the gene expression and tumor progression. By applying LASSO regression analysis, we established a KIRC survival model based on five ASB genes (ASB6, ASB7, ASB8, ASB13, and ASB17). Additionally, ROC curve analysis was used to assess the survival model’s accuracy. Through univariate and multivariate COX regression analysis, we demonstrated that the model’s risk score might be an independent risk factor for individuals with KIRC. In summary, our KIRC survival model could accurately predict patients’ future survival. Further, we also quantified the survival model through a nomogram. This series of findings confirmed that ASB genes are potential predictive markers and targeted therapies for KIRC. Our KIRC survival model based on five ASB genes can help more clinical practitioners make accurate judgments about the prognosis of KIRC patients.
Identification of a Necroptosis-Related Prognostic Signature and Associated Regulatory Axis in Lung Adenocarcinoma
Authors: Sun Libo , Li Wenwen , Zhao Zhenhuan , Zuo Yanhua , Han Zhiwu
Published: February 2023

Background. Lung cancer is considered to be the second most aggressive and rapidly fatal cancer after breast cancer. Necroptosis, a novel discovered pattern of cell death, is mediated by Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), Receptor-interacting serine/threonine-protein kinase 3 (RIPK3), and Mixed Lineage Kinase Domain Like Pseudokinase (MLKL). Methods. For the purpose of developing a prognostic model, Least absolute shrinkage and selection operator (LASSO) Cox regression analysis was conducted. Using Pearson’s correlation analysis, we evaluated the correlation between necroptosis-related markers and tumor immune infiltration. A bioinformatics analysis was conducted to construct a necroptosis-related regulatory axis. Results. There was a downregulation of most of necroptosis-related genes in lung adenocarcinoma (LUAD) versus lung tissues but an increase in PGAM5, HMGB1, TRAF2, EZH2 levels. We also summarized the Single Nucleotide Variant (SNV) and copy number variation (CNV) of necroptosis-related genes in LUAD. Consensus clustering identified two clusters in LUAD with distinct immune cell infiltration and ESTIMATEScore. Genes related to necroptosis were associated with necroptosis, Tumor necrosis factor (TNF) signaling pathway, and apoptosis according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Four prognostic genes (ALDH2, HMGB1, NDRG2, TLR2) were combined to develop a prognostic gene signature for LUAD patients, which was highly accurate in predicting prognosis. Univariate and multivariate analysis identified HMGB1, pT stage, and pN stage as independent factors impacting on LUAD patients’ prognosis. A significant correlation was found between the level of TLR2 and NDRG2 and clinical stage, immunity infiltration, and drug resistance. Additionally, the progression of LUAD might be regulated by lncRNA C5orf64/miR-582-5p/NDRG2/TLR2. Conclusion. The current bioinformatics analysis identified a necroptosis-related prognostic signature for LUAD and their relation to immunity infiltration. This result requires further investigation.
Guttiferone BL from the Fruits of Allanblackia gabonensis Induces Mitochondrial‐Dependent Apoptosis in PA‐1 Ovarian Cancer Cells
Authors: Fankam Aimé Gabriel , Mondal Susmita , Dongmo Faustine L. M. , Nganou Blaise Kemajou , Konga Ingrid Simo , Mandal Chitra , Kuete Victor
Published: February 2023

Despite the recent advancement of treatment strategies, cancer ranks 2nd among the causes of death globally. Phytochemicals have gained popularity as an alternate therapeutic strategy due to their nontoxic nature. Here, we have investigated the anticancer properties of guttiferone BL (GBL) along with four known compounds previously isolated from Allanblackia gabonensis. The cytotoxicity was assessed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) assay. The study was extended for the assessment of the effect of GBL in PA‐1 cells apoptosis induction, cell cycle distribution, and change in mitochondrial membrane potential using flow cytometry, Western blot analysis, and real‐time PCR. Among the five tested compounds, GBL displayed significant antiproliferative effects against all tested human cancer cells (IC50 < 10μM). Moreover, GBL exhibited no significant cytotoxicity towards normal ovarian epithelial cell line (IOSE 364) up to 50 μM. GBL induced sub‐G0 cell cycle arrest and significant upregulation of cell cycle regulatory proteins of ovarian cancer cell PA‐1. Furthermore, GBL induced its apoptosis as depicted by the accumulation of cells both at the early and late apoptotic phase in Annexin V/PI assay. In addition, it decreased the PA‐1 mitochondrial membrane potential and promoted upregulation of caspase‐3, caspase‐9, and Bax and downregulation of Bcl‐2. GBL also showed a dose‐dependent inhibition of PA‐1 migration. Altogether, this study reveals that guttiferone BL, studied herein for the first time, exhibits efficient antiproliferative activity by the induction of apoptosis through the mitochondrial‐dependent pathway. Its investigation as a therapeutic agent against human cancers especially ovarian cancer should be envisaged.
Potential for Concentrated Microalgae as Replacement Diets for Juvenile Green-Lipped Mussels, Perna canaliculus
Authors: Supono Supono , Mugica Maria , Spreitzenbarth Stefan , Jeffs Andrew
Published: February 2023

The nursery culture of bivalves typically relies on the feeding of costly live microalgae, while the use of natural sources of phytoplankton for feed is uncertain due to their variable quality and abundance. Replacement diets have been applied in bivalve nursery culture to replace live microalgae with varying success. This study investigated the potential use of two concentrated microalgal diets at a range of levels of substitution with live microalgae. Shellfish Diet 1800® (called SD) and LPB™ Frozen Shellfish Diet® (called LPB) were fed to juvenile green-lipped mussels (Perna canaliculus) at five levels of substitution for live microalgae (i.e., 0, 25, 50, 75, and 100%) for 27 days. The mortality of mussels fed with 100% LPB replacement was significantly higher than the mortality of mussels fed at the lower levels of replacement, i.e., 0 and 25%. The overall final size of spat tended to decrease with the increasing level replacement of live microalgae. Proximate analysis (i.e., crude ash-free dry weight, crude protein, crude lipid, and carbohydrate) showed that only the proportion of carbohydrate content of spat was influenced by feeding treatments, with the mean total carbohydrate content of mussels tending to decrease with increasing levels of replacement of live microalgae. The results indicate that both concentrated microalgal feeds (SD and LPB) are effective at replacing live microalgae by up to 50% without compromising the survival and nutritional profile (AFDW, protein, lipid, and carbohydrate content) of juvenile green-lipped mussels and are therefore a useful resource for improving the efficiency of production.
Analysis on Efficacy of Hepatic Artery Infusion Chemotherapy with or without Lenvatinib for Unresectable Hepatocellular Carcinoma
Authors: Yuan Wei , Yue Wenchao , Wen Huabing , Wang Xueqin , Wang Qi
Published: February 2023

Introduction: For patients with advanced hepatocellular carcinoma (HCC), hepatic artery infusion chemotherapy (HAIC) is a common and mature treatment, but the safety and efficacy of HAIC combined with lenvatinib for advanced HCC patient treatment remains unclear. Therefore, this study compared the safety and efficacy of HAIC with or without lenvatinib in unresectable HCC patients. Methods: We retrospectively analyzed 13 unresectable advanced HCC patients who received HAIC monotherapy or combination therapy of HAIC and lenvatinib. Overall survival (OS), disease control rate (DCR), objective response rate (ORR), progression-free survival (PFS), incidence of adverse events (AEs), and changes in liver function were compared between the two groups. We applied a Cox regression analysis to evaluate the independent risk factors affecting survival outcomes. Results: The ORR in the HAIC+lenvatinib group was markedly increased compared to the HAIC group (p < 0.05), while the DCR in the HAIC group was higher (p > 0.05). No notable difference was found between the two groups in median OS and PFS (p > 0.05). Compared to the HAIC+lenvatinib group, more patients had improved liver function in the HAIC group after treatment, but the difference was not dramatical (p > 0.05). The AEs incidence was 100.00% in both groups, which was relieved with corresponding treatment. Besides, Cox regression analysis did not identify independent risk factors related to OS and PFS. Conclusion: Combination therapy of HAIC and lenvatinib notably performed better than the HAIC monotherapy in patients with unresectable HCC in terms of ORR and was well tolerated, which deserves further investigation with large-scale clinical trials.
Aortic Stenosis and Aortic Valve Replacement among Patients with Chronic Kidney Disease: A Narrative Review
Authors: Rivera Frederick Berro , Cu Maria Victoria Valenzona , Cua Sharmaine Jesselyn , De Luna Deogracias Villa , Lerma Edgar V. , McCullough Peter A. , Kazory Amir , Collado Fareed Moses S.
Published: February 2023

Background: Aortic stenosis (AS) can present with dyspnea, angina, syncope, and palpitations, and this presents a diagnostic challenge as chronic kidney disease (CKD) and other commonly found comorbid conditions may present similarly. While medical optimization is an important aspect in management, aortic valve replacement (AVR) by surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR) is the definitive treatment. Patients with concomitant CKD and AS require special consideration as it is known that CKD is associated with progression of AS and poor long-term outcomes. Aims and Objectives: The aim of the study was to summarize and review the current existing literature on patients with both CKD and AS regarding disease progression, dialysis methods, surgical intervention, and postoperative outcomes. Conclusion: The incidence of AS increases with age but has also been independently associated with CKD and furthermore with hemodialysis (HD). Regular dialysis with HD versus peritoneal dialysis (PD) and female gender have been associated with progression of AS. Management of AS is multidisciplinary and requires planning and interventions by the heart-kidney team to decrease the risk of further inducing kidney injury among high-risk population. Both TAVR and SAVR are effective interventions for patients with severe symptomatic AS, but TAVR has been associated with better short-term renal and cardiovascular outcomes. Implications for Practice: Special consideration must be given to patients with both CKD and AS. The choice of whether to undergo HD versus PD among patients with CKD is multifactorial, but studies have shown benefit regarding AS progression among those who undergo PD. The choice regarding AVR approach is likewise the same. TAVR has been associated with decreased complications among CKD patients, but the decision is multifactorial and requires a comprehensive discussion with the heart-kidney team as many other factors play a role in the decision including preference, prognosis, and other risk factors.
Multi-view Feature Learning for the Over-penalty in Adversarial Domain Adaptation
Authors: Zhang Yuhong , Wu Jianqing , Zhang Qi , Hu Xuegang
Published: February 2023

Domain adaptation aims to transfer knowledge from the labeled source domain to an unlabeled target domain that follows a similar but different distribution. Recently, adversarial-based methods have achieved remarkable success due to the excellent performance of domain-invariant feature presentation learning. However, the adversarial methods learn the transferability at the expense of the discriminability in feature representation, leading to low generalization to the target domain. To this end, we propose a Multi-view Feature Learning method for the Over-penalty in Adversarial Domain Adaptation. Specifically, multi-view representation learning is proposed to enrich the discriminative information contained in domain-invariant feature representation, which will counter the over-penalty for discriminability in adversarial training. Besides, the class distribution in the intra-domain is proposed to replace that in the inter-domain to capture more discriminative information in the learning of transferrable features. Extensive experiments show that our method can improve the discriminability while maintaining transferability and exceeds the most advanced methods in the domain adaptation benchmark datasets.
Integrating Functional Status Information into Knowledge Graphs to Support Self-Health Management
Authors: Dragoni Mauro , Bailoni Tania , Donadello Ivan , Martin Jean-Claude , Lindgren Helena
Published: February 2023

Functional Status Information (FSI) describes physical and mental wellness at the whole-person level. It includes information on activity performance, social role participation, and environmental and personal factors that affect the well-being and quality of life. Collecting and analyzing this information is critical to address the needs for caring for an aging global population, and to provide effective care for individuals with chronic conditions, multi-morbidity, and disability. Personal knowledge graphs (PKGs) represent a suitable way for meaning in a complete and structured way all information related to people's FSI and reasoning over them to build tailored coaching solutions supporting them in daily life for conducting a healthy living. In this paper, we present the development process related to the creation of a PKG by starting from the HeLiS ontology in order to enable the design of an AI-enabled system with the aim of increasing, within people, the self-awareness of their own functional status. In particular, we focus on the three modules extending the HeLiS ontology aiming to represent (i) enablers and (ii) barriers playing potential roles in improving (or deteriorating) own functional status and (iii) arguments driving the FSI collection process. Finally, we show how these modules have been instantiated into real-world scenarios.
THE GENUS PLACOSPONGIA (DEMOSPONGIAE: CLIONAIDA) FROM THE COLOMBIAN CARIBBEAN
Authors: DAVID-COLÓN JESÚS , ZEA SVEN , MARÍN-CASAS DAIRO
Published: February 2023

The genus Placospongia Gray, 1867 is a group of sponges widely distributed in the world. It currently has 11 valid species, where five of those, Placospongia caribica Rützler et al., 2014, P. cristata Boury-Esnault, 1973, P. intermedia Sollas, 1888, P. ruetzleri van Soest, 2017 and P. giseleae Mácola & Menegola, 2021, are distributed in the Central Western Atlantic. The Colombian Caribbean has the records of P. intermedia and P. ruetzleri. In this research, the taxonomy of the genus Placospongia in Colombia was reviewed, describing four species, two of which are new to science: P. colombiensis sp. nov. and P. soesti sp. nov.; and P. cristata is a new record for the Colombian Caribbean. Therefore, the number of species of the genus is expanded to 13 for the world, to eight for the Western Atlantic, and to five for Colombia, ranking it as the country with the most species of the genus for the Western Atlantic. Some of the misassigned records for Indo‒Pacific species are relocated to species present in the Caribbean. Finally, a taxonomic key is given to identify the species of the Caribbean Sea.
Inorganic pyrophosphatase, a human prostate cancer activator
Authors: Wang Cezheng , Cui Zhiqiang , Xu Lei , Li Ming
Published: February 2023

Prostate cancer (PCa) represents a common tumor in men. Inorganic pyrophosphatase (PPA1) can promote inorganic pyrophosphate (PPi) hydrolysis. However, whether PPA1 participates in castration-resistant prostate cancer (CRPC) is unclear. PPA1 expression was herein determined by immunohistochemistry
along with analysis of cell behaviors by flow cytometry and CCK-8 assay. Cell invasion was measured by BD Matrigel matrix. PPA1 was found to be significantly upregulated and positively correlated with Gleason grade of PCa. PPA1 expression was significantly higher in the PC-3 and DU145 cells
than LNCaP cells and Benign prostatic hyperplasia (BPH)-1 cells. Additionally, stable overexpression of AR reduced PPA1 expression, implying the important roles of PPA1 in CRPC pathogenesis. Moreover, knockdown of PPA1 inhibited cell activities and behaviors. Furthermore, silencing of PPA1
reduced the expression of cell proliferation markers Ki-67 and PCNA, cell cycle protein cyclin D1, cyclin E, c-Myc, and MMP-2/9. Moreover, it also inhibited epithelial to mesenchymal transition (EMT) by upregulating E-cadherin and ZO-1, but downregulating N-cadherin and ZEB-2. Mechanistically,
silencing of PPA1 inhibited NF-κB activation through reduction of IκBα and p65 phosphorylation. Our findings provide a critical link between PPA1 and CRPC.
Treatment activity of budesonide-loaded poly(lactic-co-glycolic acid) microspheres in infant bronchiolitis
Authors: Yu Ping , Tian Jianhong
Published: February 2023

Bronchiolitis is a common respiratory disease in infants with poor autoimmune function and narrow airways, resulting in a higher incidence. Despite great advances in medical technology, infants remain vulnerable to complications affecting the effectiveness of treatments. Therefore,
suitable drug carriers for long-term local administration are the key to improve treatment efficiency. In this study, budesonide-loaded PLGA microspheres were successfully prepared by emulsification–solvent volatilization method. The microspheres had smooth and nearly spherical surfaces,
and the size was 8.0–11.8 μm, with a high encapsulation rate and drug loading capacity. The slow degradation of PLGA allows enables budesonide to exert long-term and sustained effects, representing a novel method for treating infant bronchiolitis. The application value of the
method for infant bronchiolitis was determined, and the relevant mechanism was explored.
A review of quality of recycled aggregate and its effect on durability of recycled aggregate concrete
Authors: Sun Daosheng , Shen Shansan , Huang Wei , Liu Kaiwei , Wang Aiguo , Chen Jing
Published: February 2023

Due to their high porosity and many interface transition zones, the low-quality recycled aggregates (RA) used in recycled concrete have a higher permeability than those used in new concrete. This makes it easier for hazardous ions to enter the concrete and increases the permeability.
The components of the aggregates, the content of the mortar attached to aggregates, and the original concrete strength all play a role in the recycled aggregate’s quality. The components of recycled aggregate are complex, and the loose porous structure of bricks will increase the amount
of water that recycled concrete absorbs. Additionally, external moisture and ions are more likely to reach the core of the concrete, reducing its durability. If more adhesive mortar is attached or if the original concrete’s strength is decreased, recycled concrete may absorb more water.
The attached mortar can be filled using slurry soaking, microbial mineralization deposition, carbonization curing, and other methods to strengthen recycled concrete. Finally, this work offers a reference for future research on the use of recycled aggregates in engineering.
Variations in Summer Extreme Hot–Humid Events over Eastern China and the Possible Associated Mechanisms
Authors: He Wenyue , Chen Huopo , Ma Jiehua
Published: February 2023

This study aimed to explore the changing characteristics of summer, compound, extreme hot–humid events over eastern China in recent decades and the associated underlying mechanisms. Results showed that the summer extreme hot–humid events over eastern China have tended to increase but with strong interannual variability in recent decades. Further analyses indicated that the summer sea surface temperature (SST) anomalies over the northwest Pacific (NW Pacific) and western tropical Pacific, and the May Arctic sea ice concentration (SIC) anomalies are the key elements that are closely connected to the variations in extreme hot–humid events over eastern China. The positive SST anomalies over the NW Pacific in summer, on the one hand, could strengthen the local circulation patterns that lead to the anomalous anticyclonic circulation over eastern China. On the other hand, the positive SST anomalies over the western tropical Pacific excite an anomaly pattern similar to the Pacific–Japan pattern that weakens the westerly jet and enhances the anticyclone circulation anomalies over the upper level of eastern China. Both of them provide favorable conditions for extreme hot–humid events over eastern China with increased moisture and temperatures. The sensitivity experiments by the Community Atmosphere Model, version 5 (CAM5), with SST forcing yield similar influencing processes to the observations. Additionally, the effect of SIC may be potentially responsible for the hot conditions in extreme hot–humid events over eastern China. The signal of declining May SIC could persist to summer and then influence the SST anomalies to its south, which could also produce a beneficial background for extreme hot–humid events to increase over eastern China by exciting the Rossby wave train propagating southeastward across the Mongolia–Lake Baikal region.
Text mining attitudes towards climate change: Emotion and sentiment analysis of the Twitter corpus
Authors: Mi Zhewei , Zhan Hongwei
Published: February 2023

Media such as Twitter has become a platform for contemporary Americans to express their opinions and allow for reaction to public opinion. Climate change is a topic of ongoing social concern. Machine-automated processing facilitates big data analysis and is suitable for analyzing a large corpus of tweets. This paper uses R tools to conduct sentiment calculation and emotion analysis on the tweet corpus from 2015 to 2018 to present the overall tendency of citizens’ attitudes toward climate change topics. The keyword analysis finds that people focus on the message’s source; CLIMATE CHANGE and GLOBAL WARMING make an association. Supporters express FEAR and SURPRISE about extreme weather and opponents’ behavior, while opponents show ANGER, DISGUST and SADNESS about politicians manufacturing climate change stories about which they have no real feelings. This study also reveals that the automatic annotation tools are still inadequate, with limited emotion lexicon and identification of negation and sarcasm.
Braiding procedure and axial compressive behaviors of three-dimensional integrated braided composite three-way circular tubes
Authors: Gao Xinyu , Wang Qihang , Sun Baozhong , Gu Bohong , Hu Meiqi
Published: February 2023

The three-dimensional braided composite multi-way tube is one kind of high strength joint with a unique seamless braided microstructure. Here we report a new method to prepare the three-way integrated braided preform. Quasi-static axial compressive damages and strengths of the three-way braided composite tubes were tested for revealing the effects of braided structure on the compressive behaviors. We have paid more attention to braiding yarn strain distribution at the connection region and have found the braided yarns are in a uniform braided structure in this region. Compressive strength and initial stiffness can be improved by reducing branch length or increasing braiding layers. The surface strain on the branch tube shows obvious periodicity related to the braided structure while that on the connection region is affected by the bulging movement due to the compression of the three branch tubes. The main damage mechanisms are yarn breakage, yarn debonding, and kink band. This uniform braided structure paves the way to form the seamless braided structure among three branch tubes with high compressive strength.
At the Very Apex: What the Supreme Court’s Student Speech Cases Have to Teach Us About a Constitutional Right to Education
Authors: Warnick Bryan R. , Thomas Christopher D.
Published: February 2023

Background/Context:

In the 1973 Rodriguez decision, the U.S. Supreme Court held that the Constitution does not guarantee a substantive federal right to education. So far, this holding has not been adequately contextualized with many other statements the Court has made concerning the nature of education in the constitutional order. For example, since the 1969 Tinker decision, the Court has repeatedly justified curtailing student free speech by appealing to important educational goods, but the necessity of providing these educational goods has not been harmonized with the Court’s denial of a federal right to education.

Purpose/Objective/Research Question or Focus of Study:

Is the Court’s denial of a constitutional right to education consistent with how education is formulated in the Court’s other decisions related to education, particularly as found in the student speech cases?

Research Design:

A “holistic analysis” is employed to examine the Supreme Court decisions related to education. This approach interprets the different strands of the Court’s decisions related to education in light of one another (a “dialogic task”) and places the Court’s decisions into a larger context of educational thought (a “contextual task”). Specifically, with respect to the dialogic task, the focus is on reading the Court’s decisions related to a federal right to education in light of its jurisprudence related to student speech; with respect to the contextual task, the focus is on clarifying the Court’s statements related to educational goods by putting them into context with educational philosophy and theory.

Conclusions/Recommendations:

The holistic analysis leads to three observations. First, the authors find that the Supreme Court has endorsed a range of goods associated with education, including both public and private goods. Second, the Court has framed these educational goods as being closely associated with constitutional norms and the democratic order. Third, in the student speech cases, the Court has argued that these public and private educational goods are so critical that they justify the curtailment of student speech rights under the First Amendment. Bringing these observations together, it is concluded that, because education is being linked to constitutionally relevant private individual goods, and because the attainment of those goods is critical enough to overcome student speech rights, then the attainment of those goods should itself be considered a substantive, individual, constitutional right.
The Role of Vitrification in Spanish Reproductive Labs: A Cryo-revolution Led by Strategic Freezing
Authors: Lafuente-Funes Sara
Published: February 2023

Assisted reproductive technologies have expanded vastly and are frequently addressed using the language of revolution. The last two decades witnessed important transformations in Spanish repromarkets, some of which are linked to one freezing technique: vitrification. This cryotechnique tends to be presented by professionals as revolutionary as well, even if in a humbler way: a technique with the capacity to revolutionize reproductive labs. Celebrated for its ability to freeze oocytes, the introduction and assimilation of vitrification have implied many transformations in Spanish clinics and the broader reproductive industry in Spain. This paper describes the role of vitrification from the point of view of the labs, drawing on interviews with professionals and observations of laboratory work, and focusing on the changes, which include but are not restricted to freezing oocytes. I argue that vitrification has increased the role of cryopreservation in reproductive labs overall in Spain, expanding the use of strategic, short-term freezing of embryos. This is discussed as part of a “cryomedicalized” turn, using Charlotte Kroløkke and Anna Sofie Bach’s term, which enlarges the scope of medicalization through optimization and prevention, in the context of late reproduction and a strong reproductive market.
Intellectual Profiles of Clinic-Referred Preschoolers
Authors: Labelle Fannie , Béliveau Marie-Julie , Jauvin Karine , Akzam-Ouellette Marc-Antoine
Published: February 2023

Intellectual impairments in preschoolers have been widely studied. A regularity that emerges is that children’s intellectual impairments have an important impact on later adjustments in life. However, few studies have looked at the intellectual profiles of young psychiatric outpatients. This study aimed to describe the intelligence profile of preschoolers referred to psychiatry for various cognitive and behavioral problems in terms of verbal, nonverbal, and full-scale IQ and to examine their association with diagnoses. Three hundred four clinical records from young children aged under 7 years and 3 months who consulted at an outpatient psychiatric clinic and who had one intellectual assessment with a Wechsler Preschool and Primary Scale of Intelligence were reviewed. Verbal IQ (VIQ), Nonverbal IQ (NVIQ), and Full-scale IQ (FSIQ) were extracted. Hierarchical cluster analysis using Ward’s method was employed to organize data into groups. The children had, on average, a FSIQ of 81, which is significantly lower than that expected in the general population. Four clusters were identified by the hierarchical clusters analysis. Three were characterized by low, average, and high intellectual ability. The last cluster was characterized by a verbal deficit. Findings also revealed that children’s diagnoses were not related to any specific cluster, except for children with an intellectual disability with, as expected, low abilities. Children referred to an intellectual assessment in an early childhood mental health clinic showed an altered intellectual development, more specifically in the verbal domain.
Doctor, Indian nationalist and humanitarian: Mukhtar Ahmad Ansari (1880–1936)
Authors: Cihat İzgi Mahmut , Ekin Ümit
Published: February 2023

Mukhtar Ahmad Ansari was a doctor and remarkable political figure in the late 19th century and the first half of 20th century. After studying medicine in Edinburgh, he returned to his country and became interested in political issues. Not unlike other educated Indian Muslims, Ansari first expressed his concerns about the situation in the Ottoman empire and went to Istanbul as the head of the medical mission. Ansari, who became more interested in politics after his days in Istanbul, came to the forefront as one of the leading figures of the Indian independence movement. Along with Mahatma Gandhi (1869–1948), Ansari did not engage in violence but supported the unity of Muslims and Hindus and opposed communalism. Despite his active political life, Ansari continued his medical studies with great seriousness and played an active role in establishing the Delhi Medical Association in 1914. During this period, his most important aim was to graft animal testicles onto human beings.
Australia’s Pharmacology Research: A Scientometric Assessment of High-Cited Papers During 2002–2021
Authors: Ahmed K.K. Mueen , Gupta B.M. , Mamdapur Ghouse Modin
Published: February 2023

Objectives

To analyze Australia’s high-cited papers (HCPs) receiving ≥100 citations in pharmacology during 2002–2021 and examine the research characteristics, study performance of the top 30 leading participating organizations and authors, and identification of top 30 journals publishing in this area and sub-fields of their research.

Materials and Methods

Australia’s HCPs on pharmacology research from the top 30 most productive organizations were identified and extracted from the Scopus database from 2002 to 2021 on 21 September 2022 using a search strategy. Select bibliometric measures were utilized to evaluate the publication productivity of important players in this area. The network analysis was performed to evaluate the collaborative interactions amongst the countries, organizations, authors, and keywords.

Results

Of the 19,418 Australia’s publications (articles) in pharmacology from the top 30 most productive organizations during 2002–2022, only 685 (3.53%) were HCPs, which together received 1,14,623 citations, averaging 164.4 citations per paper (CPP) and the citations ranged from 100 to 1,230. Two papers had more than 1,000 citations and 16 papers had 500 citations. Of the 685 HCPs, 40.58% (278) and 11.39% (78) received external funding support and were international collaboratives. The most productive organizations were Monash University (n = 155), the University of Queensland (n = 111) and the University of Melbourne (n = 97). The most impactful organizations in terms of CPP and relative citation index (RCI) were James Cook University (203.22 and 1.21), Australian National University (196.67 and 1.18) and Queensland University of Technology (193.45 and 1.16). The most productive authors were J. Li (n = 24), C. J. H. Porter (n = 24) and R. L. Nation (n = 23) (Monash University, Melbourne); and the most impactful authors in terms of CPP were A. Christopoulos (Monash Institute of Pharmaceutical Sciences, Melbourne) (288.21), C.W. Pouton (Monash University, Melbourne) (241.50), and D.L. Peterson (University of Queensland, Brisbane) (225.58). The most productive journals were Antimicrobial Agents and Chemotherapy (n = 59), Environmental Pollution (n = 43) and Journal of Medicinal Chemistry (n = 42). The most impactful journals in terms of CPP were Nature Reviews Drug Discovery (371.8), Antiviral Research (286.86) and European Journal of Pharmaceutical Sciences (253.0). The most important keywords with their frequency of appearances were Animal Experiments (108), Metabolism (76), Drug Effects (67), Animal Models (65), Protein Expression (64), Anti-Bacterial Agents (62), Drug Delivery Systems (54), Drug Formulation (44), Signal Transduction (42), and so on.

Conclusion

There is an urgent need to increase national funding and expand international collaboration in priority areas, which will help to increase and diversify research output and improve research impact.
Congenital Pulmonary Airway Malformations With a Reconsideration and Current Perspective on the Stocker Classification
Authors: Dehner Louis P. , Schultz Kris Ann P. , Hill D. Ashley
Published: February 2023

Congenital cystic pulmonary lesions (CCPLs) are represented by the following entities: congenital pulmonary airway malformation (CPAM), formerly congenital cystic adenomatoid malformation, extra- and intralobar sequestration (EIS), congenital lobar emphysema (overexpansion), and bronchogenic cyst. The developmental model of CPAM histogenesis by Stocker proposed perturbations designated as CPAM type 0 to type 4 without known or specific pathogenetic mechanisms along the airway from the bronchus to the alveolus. This review highlights mutational events either at the somatic level in KRAS (CPAM types 1 and possibly 3) or germline variants in congenital acinar dysplasia, formerly CPAM type 0, and pleuropulmonary blastoma (PPB), type I, formerly CPAM type 4. The potential for overt malignant progression exists in the case of PPB type I and CPAM type 1 in some cases to well-differentiated mucinous adenocarcinoma. On the other hand, CPAM type 2 is an acquired lesion resulting from interruption in lung development secondary to bronchial atresia. The latter is also regarded as the etiology of EIS whose pathologic features are similar, if not identical, to CPAM type 2. These observations have provided important insights into the pathogenetic mechanisms in the development of the CPAMs since the Stocker classification.