bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the outcomes of post-diverticulitis investigations, A multicentre cohort study including 1052 patients
Authors: Abdelrahim Ahmed , Ali Omer , Kamali Dariush , Reddy Anil , Harrison Sanjay , Boshnaq Mohamed , Abudeeb Haytham , Ashoush Fouad , Qulaghassi Muhaned , Rahman-Casans Syed-Fida , Osman Khalid
Published: January 2024

Aim: This is the largest single study, to date, which aims to assess the yield of the endoscopic investigations performed following acute diverticulitis.
Method: A retrospective multi-centre study included patients with multislice computed tomography (MSCT) proven diverticulitis, in three NHS hospitals, between January 2016 and December 2022. The primary outcome was the rate of colonic cancer in the diseased segment. Secondary outcomes included the rate of malignancy in the non-diseased colonic segments, the benign colonic polyp detection rate, the rate of malignancy in the resected surgical specimens in patients who underwent an emergency surgery on the index admission and the rate of complications in the investigated group.
Results: 1052 patients were included in the study; out of which 680 (64.6%) were females with median age of 65 (21-91) years. 694 patients (66%) had uncomplicated diverticulitis (Hinchey stage 1A) while 358 (39%) had complicated diverticulitis (Hinchey stage 1B - 4). Following the acute episode, 715 (68%) patients had subsequent endoscopic evaluation. The incidence of colorectal cancer (CRC) or advanced adenomas (AA) in patients with uncomplicated (Hinchey 1A) diverticulitis was 0.14%. The incidence of CRC/AA in patients with Hinchey 1b and Hinchey 2 was 1.4 % and 4.4% respectively. 18/98 patients (18.4%) out of the patients who underwent emergency colonic resection for suspected perforated diverticulitis had histological evidence of colonic malignancy.
Conclusion: Colonoscopy following uncomplicated diverticulitis has a low yield. It should be reserved for patients with complicated diverticulitis and those with uncomplicated diverticulitis who have suspicious radiological or clinical manifestations. In patients who undergo emergency surgery, oncological principles should be applied whenever possible.
Empirical identification of feasible and strategic climate policies
Authors: Mealy Penny , Ganslmeier Michael , Godinho Catrina , Hallegatte Stephane
Published: January 2024

The political and institutional feasibility of implementing climate policy appears as a key impediment to accelerating climate action. Drawing on a rich dataset of climate policies introduced globally over the last 50 years, this paper explores global patterns in climate policy adoption to understand how climate policy feasibility is shaped by countries’ existing policies and institutional capacity. By constructing a ‘Climate Policy Space’ network based on the co-occurrence of climate policies across countries, we show that climate policy adoption is path-dependent, and therefore predictable: countries are significantly more likely to introduce policies that require similar institutional capacity and policy know-how to policies they have previously introduced. Exploiting this finding, we construct empirically validated ‘Climate Policy Feasibility Frontiers’ which, for a given country, identify policies that are (1) likely to be easiest to introduce; (2) have the greatest advantages in terms of capacity building and therefore facilitate further climate action; and (3) have the largest emissions reduction potential. As a complement to traditional cost-benefit analysis, such feasibility frontiers can inform more realistic and strategic climate policy prioritization across countries.
CD61 + LDNs drive cancer metastasis by upregulating CCDC25 expression via DNA-TLR9-NF-kB axis in HCC
Authors: Guan Xiangqian , Lu Yuyan , wang Chuanzheng , Zhan Ping , Chen Zhigao
Published: January 2024

Background
A subset of neutrophils isolated from peripheral blood mononuclear cells (PBMC) has recently been described in cancer patients.
Methods
Double gradient centrifugation was used to separate neutrophil subset. Western blot assay was performed to assess CCDC25 expression level.
Results
In this study, we found that low density neutrophils(LDNs) were highly enriched in metastatic hepatocellular carcinoma (HCC) patients compared to non-metastatic HCC patients. Then, we showed that the most prominent marker on LDNs was CD61, compared to high density neutrophils(HDNs). The CD61+LDNs subset displayed an increased ability in triggering metastasis, producing free DNA, and synthesizing cytokine CCL5, and a decreased ability in forming NETs, synthesizing cytokine TNF-α and producing ROS, as compared with CD61−LDNs or HDNs. Transcriptomic analysis revealed that CD61+LDNs displayed distinct gene transcribe from CD61−LDNs and HDNs. The abundance of circulating CD61+LDNs was negatively correlated with disease prognosis, and positively correlated with the expression of CCDC25 within tumor. These CD61+LDNs increased the invasion of HCC cells by upregulating CCDC25. Mechanistically, the CD61+LDN-derived free DNA, excluding the NETs-DNA, enhanced the invasiveness of HCC cells and triggered their metastatic potential, which was mediated by TLR9-NF-κB-CCDC25 signaling. Blocking this signaling reversed the invasion of the CD61+LDNs-evoked HCC cells. In vivo, we consistently showed that CD61+LDNs enhanced HCC metastasis to the lungs.
Conclusions
Overall, our findings showed that a subset of CD61+LDNs has pro-metastatic effects on HCC, which might be used for targeting HCC in the clinical setting.
Basque Optimization: a new cost function prediction based optimization algorithm
Authors: Zulueta Asier , Zulueta Ekaitz , Garcia-Ortega Joseba , Ispas-Gil Decebal Aitor , Fernandez-Gamiz Unai , Lopez-Guede Jose Manuel
Published: January 2024

Authors propose a new intelligent optimization algorithm. This algorithm tries to learn the cost function shape in order to decide which points must be evaluated, and how many optimization iterations are enough. As far as the authors know, there is no optimization algorithm that applies prediction with all the evaluated points. Authors have performed a comparison study of the error prediction made by both the proposed algorithm, and the best-known intelligent optimization algorithm: Particle Swarm Optimization. The results show that this new algorithm is able to learn different cost functions more accurately. The cost function set proposed in this article are continuous evaluated functions which have very diverse mathematical shapes. The authors have concluded that the proposed algorithm is able to choose the evaluation points more appropriately.
Studies on diffusion of moisture through nanoclay/vinylester/glass nanocomposites
Authors: Kamanna Bommanna , Anupama B S , Hatti Prashant S
Published: January 2024

The goal of this study was to see how mud content affected nanoclay/vinylester/glass composites submerged in 13.5 pH soluble solutions for up to 100 days. The corruptions in UTS, Impact characteristics, Flexural Strength and Interlaminar Shear Strength were investigated, as well as the samples' diffusivity. Vinylester/glass composites, have the highest dampness retention of 0.85 percent, while 8wt percent nanoclay/vinylester/glass nanocomposites have the lowest dampness retention of 0.55 percent. The diffusion co-efficient was determined to be 9.53X10− 13 m2/sec for nanoclay/vinyl ester/glass composites with 8wt percent and 2.98X10− 13 m2/sec for nanoclay/vinyl ester/glass composites with 8wt percent.Mechanical characteristics dropped at a faster rate as a result of moisture retention. In comparison to vinylester/glass composites, 4wt% nanoclay/vinylester/glass composites displayed improved performance in salt environment moulding of all composite classes. XRD was used to concentrate scattering, and Scanning Electron Microscopy was used to focus on the ductile cracked samples.
Elucidating the Mechanism and Selectivity of [3+2] Cycloaddition: A DFT and Molecular Docking Investigation of the Reaction of 6-Butoxy-5,6- Dihydro-4H-1,2-Oxazine 2-Oxide with Dimethyl Maleate
Authors: Mohammad-Salim Haydar , de Julián-Ortiz Jesus Vicente , Islam Mohammad Shahidul , Almutairi Tahani Mazyad , Benmetir Sofiane
Published: January 2024

The [3 + 2] cycloaddition (32CA) reactions involving 6-butoxy-5,6-dihydro-4H-1,2-oxazine 2-oxide and dimethyl maleate are examined in this study. Molecular electron density theory (MEDT) is applied at the M06-2X/6-311G(d,p) level, coupled with the D3 dispersion correction. The nitrone species are identified as zwitterionic entities through an analysis of the electron localization function (ELF). Conceptual DFT indices are utilized to classify dimethyl maleate as the electrophilic component and the nitrone as the nucleophilic counterpart. The [3 + 2] cycloaddition processes are predominantly governed by kinetic control, as indicated by activation free energies of -23.64 and − 11.42 kcal.mol − 1 for the exo and endo pathways, respectively, aligning with experimental findings. The formation of a pseudoradical center initiates at carbon atoms C3 and C4. A subsequent docking analysis is conducted on cycloadducts 3 and 4 in relation to the main protease of SARS-CoV2 (6LU7), alongside the co-crystal ligand. The results of this analysis reveal that cycloadducts 3 exhibit higher binding energy, while cycloadducts 4 display lower binding energy compared to the co-crystal ligand.
Some Identities Linking Number Theory and Graph Theory
Authors: Bhaskar L. , Rao A. K.S. Chandrasekhar
Published: January 2024

In this paper, we obtain some identities linking number theory and Graph theory, Examples are provided for illustration.
AMS Subject Classification: 68R10, 68R01, 05C05, 05C10.
Abnormal brain networks in Meiges Syndrome based on centrality analysis and functional network connectivity
Authors: Wang Yifei , Yang Aocai , Song Zeyu , Chen Yu , Ma Guolin , Tang Xiaoying
Published: January 2024

Background
Meige's syndrome (MS) is a neurologically disabling disorder characterized by visual impairment, mastication, and swallowing difficulties. Emerging evidence suggests that MS may stem from disturbances in brain networks. However, current literature inadequately probes the centrality and functional connectivity within these networks.
Purpose
This study aims to compare the brain networks of MS patients with those of healthy controls (HC). We focus on examining changes in intrinsic connectivity, the significance of nodes within the global brain network, and functional network connectivity (FNC). Additionally, we seek to identify potential correlations between neuroimaging findings and clinical scales.
Method
We employed centrality analysis and mediation analysis of brain networks using resting-state fMRI data. Voxel-level degree centrality (DC) and eigenvector centrality (EC) served as key features. Independent component analysis was utilized to assess functional connectivity at the network level.
Results
Analyses of EC and DC identified abnormal areas in MS patients predominantly in the right thalamus, left middle occipital gyrus, and Cerebellum Inferior. Mediation analysis indicated that disease severity and course of disease are fully mediated by DC values in the right cerebellum. FNC results highlighted abnormal connections in cerebellar-subcortical, memory retrieval-cingulo-opercular task control, and ventral attention-sensory/somatomotor hand networks in MS patients.
Conclusions
Our findings reveal multiple abnormalities in centrality and functional connectivity of brain networks in MS patients. Notably, disease severity correlates with alterations in these, potentially influencing disease progression.
The role of moisture and salt distribution in the weathering of the medieval cave town of Uplistsikhe, Georgia
Authors: Sass Oliver , Heil Stefanie
Published: January 2024

Knowledge of salt and moisture distribution is a key factor for understanding rock decay at cultural heritage sites. The cave town of Uplistsikhe in Georgia, carved from sandstone in late bronze age to medieval times, suffers from progressive scaling and flaking processes. Multi-method investigations of rock moisture and salt distribution were carried out in order to better understand the patterns of decay. Salt distribution was investigated using drill dust samples and paper pulp poultices; moisture was determined by 2D-resistivity and handheld microwave sensors, supplemented by infrared thermography. The combined results from the different methods revealed a complex pattern of salt and moisture distribution. An most sites, K2SO4 (arcanite) and its hydrates dominate, sometimes in combination with CaSO4 (gypsum). At one site (Grandhall), halite (NaCl) and niter (KNO3) prevail. Sulphates are assumed to be a legacy of air pollution; origin of halite and niter remains unsolved but might be due to concrete reinforcements. Two main sources of moisture were evidenced depending on season and spatial situation: (1) Condensation of air humidity at cool cave backwalls in spring (combined with and aided by salt efflorescence), evidenced by 2D-resistivity and infrared thermography; (2) seepage along joints particularly at the cave backwalls and roofs, evidenced by handheld microwave sensors. Further investigations should focus on identifying seepage pathways and on clarifying the origin of destructive halite and nitrates.
Shape stability of a quadrature surface problem in infinite Riemannian manifolds
Authors: DJITE Ababacar Sadikhe , SECK Diaraf
Published: January 2024

In this paper, we give a simple control on how an optimal shape can be characterized. The framework of Riemannian manifold of infinite dimension is essential. And the covariant derivative plays a key role in the computation and in the analysis of qualitative properties from the shape hessian. The control depends only on the mean curvature of the domain which is a minimum or a critical point. In the two dimensional case, the Gauss Bonnet theorem gives a control in the setting of the algorithm for the minimum.
Mathematical classification subject: 49Q10, 53B20
Multimodal imaging and genetic screening in Mexican patients with Gyrate Atrophy. Identification of novel OAT pathogenic variants.
Authors: Díazceballos-García Ana Lía , Matsui Rodrigo , Miranda María Graciela Chairez , Padrón Jaime Francisco Rosales , Graue-Wiechers Federico , Zenteno Juan Carlos
Published: January 2024

Purpose
Description of retinal phenotype by structural and functional testing, ornithine plasma levels and mutational data of OAT gene in patients with Gyrate Atrophy (GA).
Methods
Ophthalmologic examination, fundus photography (CFP), autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), Goldmann perimetry (GP), full-field electroretinogram (ffERG) and chromatic perimetry (CP) testing were performed. Ornithine plasma levels were measured. Sanger sequencing mutational analysis of the coding exons and exon-intron junctions of the OAT gene were analyzed.
Results
Twelve eyes of seven Mexican patients with GA were included. CFF showed peripheric patches of chorioretinal atrophy; FAF revealed peripheric oval areas of hypoautofluorescence; SD-OCT exhibited outer retinal tubulations in 58%, cystoid macular edema in 50%, epiretinal membrane in 42%, foveoschisis and staphyloma in 17%, and hyperreflective deposits in 100% of the eyes; GP showed constricted visual fields in 100% of the eyes; ffERG revealed preserved photopic response in 17% and preserved scotopic response in 17% of the eyes; CP exposed a deficit in generalized response of rods and cones in 100% of the eyes. Mean ornithine plasma levels were 509.5 µmol/L. One patient with genetic confirmation of GA had normal ornithine plasma levels (48 µmol/L). Molecular findings in OAT gene detected two novel pathogenic variants: c.796 C > T (p.Gln266*) and c.721_722dupCC (p.Asp242ArgfsTer6).
Conclusion
This study provides new information regarding functional and structural diagnosis in patients with GA, expands the understanding of retinal phenotype in patients with GA, reports two novel mutations and presents the first case of GA confirmed by genetic testing with normal ornithine levels.
Antitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
Authors: Han Jung-Min , Oh Kyu-Young , Choi Su-Jung , Lee Won-Woo , Jin Bo-Hwan , Kim Ji-Hoon , Yu Hyun-Ju , Kim Ryan Jin Young , Yoon Hye-Jung , Lee Jae-Il , Hong Seong-Doo , Cho Sung-Dae
Published: January 2024

Purpose: This study investigates the role and effectiveness of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in oral cancer, focusing on the clinical relevance of EGFR and myeloid cell leukemia-1 (Mcl-1) in head and neck cancers (HNCs). It aims to explore the molecular mechanism of afatinib, a TKI, in treating human oral cancer.
Methods: We conducted an in silicoanalysis using databases like The Cancer Genome Atlas, Gene Expression Omnibus, and Clinical Proteomic Tumor Analysis Consortium, along with immunohistochemistry staining, to study EGFR and Mcl-1 expression in HNCs. For investigating afatinib's anticancer properties, we performed various in vitro and in vivo analyses, including trypan blue exclusion assay, Western blotting, 4′-6-diamidino-2-phenylindole staining, flow cytometry, quantitative real-time PCR, Mitochondrial membrane potential assay, overexpression vector construction, transient transfection, and a tumor xenograft model.
Results: Higher expression levels of EGFR and Mcl-1 were observed in HNC patient tissues compared to normal tissues, with their co-expression significantly linked to poor prognosis. There was a strong correlation between EGFR and Mcl-1 expressions in oral cancer patients. Afatinib treatment induced apoptosis and suppressed Mcl-1 in oral cancer cell lines without the EGFR T790M mutation. The mechanism of afatinib-induced apoptosis involved the EGFR/mTOR/Mcl-1 axis, as shown by the effects of mTOR activator MHY1485 and inhibitor rapamycin. Afatinib also increased Bim expression, decreased mitochondrial membrane permeabilization, and reduced cytochrome c release. It significantly lowered tumor volume without affecting body, liver, and kidney weights.
Conclusion: Afatinib, targeting the EGFR/mTOR/Mcl-1 axis, shows promise as a therapeutic strategy for oral cancer, especially in patients with high EGFR and Mcl-1 expressions.
UV-curable polyurethane-based, halogen-free, CaB4O7 nanoparticles decorated, flexible flame-retardant films
Authors: Beyler-Çiğil Aslı , Aytekin Yusuf Samet , Ceren Özde , Yılmaz Ayşen , Esenturk Okan
Published: January 2024

In this study, combinations of phosphorous silicone methacrylate monomer (PSiMA) and CaB4O7 nanoparticles (CBO NPs) were prepared for formation of halogen-free, flame-retardant, UV-curable polyurethane acrylate (PUA) films. The addition of either PSiMA or CBO NPs to PUA increased the flame-retardancy as expected, but the PSiMA-only addition, unfortunately, had adverse effects on the physical properties. However, the combined addition of PSiMA and CBO NPs not only resulted in the best performance on flame retardancy but also recovered the polymer’s thermal and physical properties. With additives high initial decomposition temperatures were observed in the range of 175–216°C. Among the combinations, PLU-60PSi-10NP (60 phr PSiMA + 10 phr CBO NPs) resulted in the best LOI performance of 27, which is 40% more than the PLU film (PUA-based film). In addition, the film had a remarkable char formation ability of 14.5% compared to PLU. The observed high LOI values could not be explained by the high percentages of P, Si, B, and N in the films, but the synergy among the additives was also considered. In this study, we have investigated the use of a promising technique, THz spectroscopy, on the characterization of these films as well. Very interestingly, the results showed a nice correlation between the dielectric responses measured by THz spectroscopy and the mechanical properties of the films. Observed great performances along with the simple preparation methods of these newly developed halogen-free, flame-retardant, PUA-based films are expected to significantly increase their potential use in many practical applications such as automobile, leather, printing, and coatings.
Improved Path Planning Algorithm Based on EB-RRT and APF
Authors: Jing Wenhao , Gao Kai , Li Shanze
Published: January 2024

In practical operating environments, it is extremely important for mobile robots to reach the target area quickly and safely. Therefore, a new path planning algorithm, APF-EB-RRT, based on the EB-RRT algorithm was proposed in this article. The artificial potential field algorithm was introduced into the APF-EB-RRT algorithm. By adding potential field constraints that simulate the interaction between objects to the dynamic reprogramming structure, the EB-RRT algorithm can avoid the problems of high randomness and poor directionality caused by the EB algorithm. Meanwhile, the APF-EB-RRT algorithm can effectively avoid collisions between robots and obstacles, and guide robots to the target area. The effectiveness of the APF-EB-RRT algorithm was demonstrated by numerical simulation results. The APF-EB-RRT algorithm exhibited better performance in various environments than the other four algorithms. In a real dynamic environment, this algorithm can provide better path planning for mobile robots, and has good application prospects in the field of path planning.
Plate Fixation of Inferior Ramus in Pubis-Ischium Ramus Improves Mechanical Stability in Tile B Pelvic Injures: A Cadaveric Biomechanical Analysis and Early Clinical Experience
Authors: Pan Zhongjie , Hu Feng , Li Yuquan , Li Muwen , Chen Min , Huang Wengui , Qin Lili , Li Yuanjun , Liu Wei
Published: January 2024

Background
Management of inferior ramus of the pubis-ischium ramus remains controversial, and related research is sparse. The main intention of this study is to describe the biomechanical and clinical outcomes of pubis-ischium ramus fractures in Tile B pelvic injuries and to identify the feasibility and necessity of fixation of the inferior ramus of the pubis-ischium ramus.
Methods
This study comprised two parts: a biomechanical test and a retrospective clinical study. For the biomechanical tests, Tile B-type pelvic injuries were modeled in six cadaver specimens by performing pubis-ischium osteotomies and disruption of the anterior and interosseous sacroiliac ligaments. The superior and/or inferior rami of the pubis-ischium ramus were repaired with reconstruction plates and separated into three groups (A, B, and C). Specimens were placed in the standing position and were loaded axially with two-leg support for three cycles at 500 N. The displacements of sacroiliac joints at osteotomy were measured with Vernier calipers and compared using statistical software. To investigate the clinical outcomes of this technique, 26 patients were retrospectively analyzed and divided into a superior ramus fixation group (Group D) and a combined superior and inferior ramus of the pubis-ischium ramus fixation group (Group E). The main outcome measures were time of operation, blood loss, postoperative radiographic reduction grading, and functional outcomes.
Results
In the vertical loading test, Group E showed better pelvic ring stability than Group D (P < 0.05). However, the shift of the sacroiliac joints was almost identical among the three groups. In our clinical case series, all fractures in Group E achieved bony union. Group E demonstrated earlier weight-bearing functional exercise (2.54 ± 1.45 vs. 4.77 ± 2.09; P = 0.004), earlier bony union (13.23 ± 2.89 vs. 16.55 ± 3.11; P = 0.013), and better functional outcomes (89.77 ± 7.27 vs. 82.38 ± 8.81; P = 0.028) than Group D. The incidence of sexual dysfunction was significantly lower in Group E than that in Group D (2/13 vs. 7/13; P = 0.039). Bone nonunion occurred in two patients in Group D, and two patients in Group E had heterotopic ossification. None of the patients exhibited wound complications, infections, implant failures, or bone–implant interface failures.
Conclusion
Fixation of the inferior ramus of a pubis-ischium ramus fracture based on conventional fixation of the anterior pelvic ring is mechanically superior in cadaveric Tile B pelvic injury and shows rapid recovery, good functional outcomes, and low incidence of complications.
Object-oriented concept approach on rough granular lattice with discernibility object granular
Authors: Srir B. , Sathish Shakeela , Kartthik Krishnasamy , Mallik Saurav , Li Aimin , Shah Mohd Asif
Published: January 2024

The discernibility matrix acts as an efficient tool to determine decision-making problems. The discernibility matrix enhances both the logical and theoretical knowledge of an information system. Also, it evaluated the boolean function for enhancing its relevant properties. In this paper, a granular lattice has been discussed to define a consistent set, based on object-oriented concepts. An ordered pair of attributes and objects was constructed to determine the granular lattice using indiscernibility relation. We have introduced two sets, namely the maximum and minimum sets to analyze the indiscernibility object. The indiscernibility object investigates the upper approximation space and extended its effectiveness towards maximum and minimum sets. Furthermore, the properties of the maximum set and minimum set are classified using the granularity concept. An equivalency condition is framed by the maximum set and its results are examined with the help of some theorems and lemma.
Papillary thyroid carcinoma synchronous with high-grade non-Hodgkin's lymphoma: A case report
Authors: Hafi Zakaria El , Hjaouj khalil , Bencheikh Razika , Benbouzid Mohamed Anas , Oujilal Abdelilah , Essakalli Leila
Published: January 2024

Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma, accounting for up to 90% of all thyroid malignancies. The association with an hematological malignancy is very rare, representing an incidence of only 7%.
We present a case of synchronous papillary thyroid cancer and non-Hodgkin's lymphoma (NHL) and discuss possible dilemmas in diagnosis and treatment.
A 60-year-old woman with no medical or radiation history presented with a hard, immobile left supraclavicular swelling. Cervical ultrasound showed the presence of a suspicious-looking supraclavicular adenopathy with two right lobar thyroid nodules classified EU-TIRADS 4. We performed a total thyroidectomy with right central latero-cervical functional left curage and excision of the left supraclavicular adenopathy. Pathological examination revealed papillary thyroid carcinoma synchronous with high-grade non-Hodgkin's lymphoma.
After a multidisciplinary consultation, the patient received six courses of chemotherapy before undergoing irratherapy. This article highlights the importance of a multidisciplinary approach in the absence of consensus, given the rarity of this case.
Test-Retest reliability of prepulse inhibition (PPI) and PPI correlation with working memory
Authors: Freudenberg Florian , Althen Heike , Falk Kim , Bittner Robert A. , Reif Andreas , Plichta Michael M.
Published: January 2024

Objective: Sensorimotor gating is experimentally operationalized by the prepulse inhibition (PPI) of the startle response (SR). Previous studies suggest high test-retest reliability of PPI and potential correlation with working memory (WM). Here we aimed to validate and extend the test-retest reliability of PPI in healthy humans and its correlation with working memory (WM) performance.
Methods: We applied an acoustic startle PPI paradigm with four different prepulse intensities (64, 68, 72, and 76 dB) and two different WM tasks (n-back, change detection task [CDT]) in a group of 26 healthy adults (final sample size n=23). To assess test-retest reliability, we performed all tests on two separate days 28 days apart.
Results: We were able to confirm high test-retest-reliability of the PPI with a mean intraclass correlation (ICC) of >0.80 and significant positive correlation of PPI with n-back but not with CDT performance. Detailed analysis showed that PPI across all prepulse intensities significantly correlated with both the 2-back and 0-back conditions, suggesting regulation by cross-conditional processes (e.g. attention). However, when removing the 0-back component from the 2-back data, we found a specific and significant correlation with WM for the 76 dB PPI condition.
Conclusion: With the present study we were able to confirm the high test-retest reliability of the PPI in humans and could validate and expand on its correlation with WM performance.
Mit Schüler*innen über Anspruchsdimensionen eines inklusiven Sportunterrichts reflektieren - Entwicklung eines anforderungssituationsbezogenen Kompetenzprofils für Sportlehrkräfte
Authors: Meister André , Brandes Björn , Erhorn Jan
Published: January 2024

Im Rahmen eines inklusiven Sportunterrichts, an den die Ansprüche der Teilhabe, Anerkennung und individuellen Förderung aller Schüler*innen gestellt werden, werden Sportlehrkräfte mit verschiedenen Anforderungssituationen konfrontiert. Dazu zählt u.a. mit den Schüler*innen über die Ansprüche und Situationen, in denen diese verletzt werden, zu reflektieren (Greve, 2016). Jedoch ist bislang unklar, welche Kompetenzen Lehrkräfte benötigen, um diese Anforderungssituationen zu bewältigen. Einem Ansatz folgend, der Kompetenzen als Kontinuum zwischen Performanz, situationsspezifischen Fähigkeiten und Dispositionen betrachtet (Blömeke, Gustafsson & Shavelson, 2015), nimmt sich der Beitrag diesem Desiderat an. Unter der Verwendung eines integrativen Verfahrens, das sowohl kontextualisiert-performanzorientierte also auch dekontextualisiert-dispositionsorientierte Zugänge zur Modellierung miteinander verknüpft, wird ein Kompetenzprofil zur Anforderungssituation „Mit Schüler*innen über Anspruchsdimensionen eines inklusiven Sportunterrichts reflektieren“ (Erhorn & Langer, 2022, S. 108) entwickelt.
Abstract
In the context of inclusive physical education, which demands participation, recognition and individual support of all students, physical education teachers have to face different requirement situations. This includes reflecting with students on situations in which these demands are violated (Greve, 2016). However, it is not yet clear what competencies teachers need to meet these requirement situations. Following an approach that views competencies as a continuum between performance, situation-specific skills, and dispositions (Blömeke et al., 2015), this paper addresses this desideratum. Using an integrative procedure that combines both contextualized-performance-oriented and decontextualized-disposition-oriented approaches of modeling, a competency profile for the requirement situation "Reflecting with students on demands of inclusive physical education" (Erhorn & Langer, 2022, S. 108) is developed.
Finnland als Vorbild? Leistung und Körper im (inklusiven) Sportunterricht aus einer ableismuskritischen Perspektive
Authors: Mihajlovic Christopher
Published: January 2024

Dieser Beitrag wirft einen ableismuskritischen Blick auf das Leistungs- und Körperverständnis in den finnischen Sportlehrplänen. Mit Hilfe einer qualitativen Inhaltsanalyse der aktuell gültigen curricularen Richtlinien soll aus einer fähigkeitskritischen Perspektive untersucht werden, ob bzw. welches Exklusionspotenzial in den Vorgaben der finnischen Curricula eingelagert ist. Die Ergebnisse der Analyse zeigen, dass die curricularen Vorgaben zur Leistungsbewertung in Finnland kaum mit normierten Fähigkeitserwartungen und einer Orientierung an körperbezogenen Idealen einhergeht. Lediglich an vereinzelten Stellen wird ein exkludierendes Potenzial deutlich, welches sich in erster Linie auf die implizit angenommene uneingeschränkte Reflexionsfähigkeit der Lernenden bezieht.
Abstract
The purpose of the present article is to analyse the current PE curriculum in Finland from the perspective of ableism by employing qualitative content analysis. This paper particularly draws attention to the Finnish curricular approaches of assessing student performance in (inclusive) PE. The analysis examines and discusses the assessment approaches in the PE curriculum in Finland. The findings indicate that the Finnish curricular approaches provide a holistic understanding of the body and performance to deal with the increasing diversity in the student population. However, the PE curriculum also contains some exclusionary potential for those students who are not able to participate in physical activities that focus on certain normative performances, or who do not have the ability to reflect on themselves and their learning experiences.
Spatial and temporal variability analysis of snow cover parameters according to the urbanized area profile system
Authors: Lanko A. V. , Sarapulova G. I.
Published: January 2024

The purpose of the study is to analyze the spatial and temporal variability of snow cover parameters in the urbanized area of the city of Irkutsk and its adjacent areas according to the system of profiles reflecting the features of the area microrelief. Field surveys were conducted in accordance with standard recommendations for snow and geochemical surveys. Snow sampling was carried out at the entire snow depth, with the exception of the snow depth of 0.5-1 cm. Sampling points located at least 25 meters away from the roads. Snow sampling in the residential areas of the city was carried out in the places with undisturbed snow cover and free from extraneous snow banks and landfills. Global Mapper, Golden Software Surfer, Statistica software were used to carry out statistical analysis, build the models of profile sections and obtain the diagrams of snow cover parameter distribution. A 3D relief model was obtained on the basis of radar topographic survey data, which revealed a multiple formation relief of the studied area featuring mountains, high plains with undulating flat gently sloping watersheds, valleys, hollows and depressions. The height difference is up to 230 m. The diagrams of snow depth distribution built with regard to the profiles made it possible to identify the territories with the deepest snow cover. A geochemical analysis of the melt water filtrate was carried out over a three-year period. In 2021 a high correlation with electrical conductivity was found for the contents of tungsten, sodium, bromine, calcium, molybdenum, sulfur, barium, magnesium, antimony, tantalum, cesium, titanium, chromium, and silicon. The average correlation level with electrical conductivity was recorded for arsenic, copper, and lead. The analysis data obtained indicate a different contamination level of the area as a result of atmospheric precipitation in those years due to the activity of industrial facilities. The distribution patterns of the pH snow index have been revealed. It is shown that zones with pH<6 are mostly confined to the Irkutsk aluminum smelter. The zones with pH >6 are caused by the influence of the power plants using hydrocarbon fuels: gasoline, kerosene, fuel oil, diesel fuel, coal. The snow cover was subjected to field and laboratory studies using GIS technologies and physico-chemical methods. The distribution and migration of pollutants in various spatial and temporal aspects have been revealed taking into account the terrain relief. The conducted study opens up opportunities for modeling the landscape structure, taking into account meteorological parameters, phenological processes and snow cover state for the purposes of the national economy and the location of construction of various facilities.
Analisis Penerapan Konsep Desain Arsitektur Tropis pada Hotel Alila Seminyak, Bali
Authors: Nurjani Ni Putu Suda
Published: January 2024

Title: Implementation’s Analysis of Tropical Architectural Design Concepts at Alila Seminyak Hotel, Bali
 
Tropical architecture is born from efforts to adjust to the climate in the tropics. Tropical architectural design always shows the form of adaptation of buildings to the environment. Traditional Balinese houses that function as community residential units are one of the tropical architectural typologies with the main advantage of thermal comfort, especially on air circulation flow that flows well throughout the building. However, when reviewing further commercial buildings in Bali, especially star hotels, the implementation of tropical architecture is a theme that requires deep design thinking. Adjustment to Balinese regional regulations on buildings is very binding; limited sites and demands for comfort and suitability of building functions are challenging for architects to design an accommodation building with a tropical architectural concept. Alila Seminyak Hotel is one of the five-star hotels outside the ITDC Nusa Dua area, which tries to form a tropical architectural identity as the main attraction. This qualitative descriptive research takes the case study of Alila Seminyak Hotel. Assessment analysis was carried out on the physical form of the hotel building, which was then appropriated and compared with tropical architectural theory. The results of this study show that the implementation of tropical architecture in the Alila Seminyak hotel building can be classified into several main elements, namely, first is the form of laying the building period on-site, second is the orientation pattern of the building, and third is The physical design of the building emphasizes, that this building have three main concept designs, it is namely insulation, shading, and cross ventilation.
LEGAL AND TECHNICAL PROBLEMS OF DIGITISING THE MOROCCAN TAX SYSTEM
Authors:   Mohammed V University, Rabat., Rhorfi Abdelkhalek EL , Ouafa Filali ,   Souissi Faculty of Legal, Economic and Social Sciences.
Published: January 2024

Most of the economic, social and environmental reforms envisaged by countries attach crucial importance to the information revolution, which has become the major challenge of our time. Most nations are embracing it wholeheartedly, including Morocco, which has introduced a new tax reform plan with the enactment of Framework Law 19.69. This plan focuses on digitising and strengthening administrative services by relying on electronic media, which have become a pressing necessity in all Moroccan administrations. Electronic filing and electronic enforcement of all taxes are the main objective of the tax services. The 2020 pandemic has played a fundamental role in accelerating the adoption of digitisation, offering an alternative to physical interactions in various locations such as administrative departments, public institutions, markets, and others. However, this development has raised a number of tax and legal issues, particularly in terms of the technology used for electronic tax filing and payment. These changes have also had an impact on the worlds tax systems, some of which are unable to keep pace with these advances. In addition, the emergence of e-commerce has added further complexity, particularly in terms of taxation and the challenges faced with social influencers generating significant revenues. Thus, the increasing adoption of electronic means in the tax field has raised legal and technical issues related to electronic tax filing and enforcement, just as e-commerce has become a major pillar of the global economic fabric, creating its own legal and technical challenges.
LA DOCTRINE BEN GOURION DE SECURITE NATIONALE : REFERENCE INCONTOURNABLE ET CRITIQUES MULTIPLES
Authors:   Chercheur Doctorant Sous la Direction du Pr. Ahmed Ouedghiri Ben Otmane a lUniversite Mohammed V, Royaume du Maroc., Aiche Karim , Ouedghiri Ben Otmane Ahmed ,   Professeur de Lenseignement Superieur, Laboratoire de Droit Public et Sciences Politiques, Faculte des Sciences Juridiques, Economiques et Sociales de Rabat - Agdal, lUniversite Mohammed V, Royaume du Maroc.
Published: January 2024

Human societies development leads to the evolution of the national security concept for its classic definition which turns around the military action, to move to multidimensional concept-based definition with different characteristics. Ben Gurion, Israels former Prime Minister, is always highlighted in all studies of the Israels national security doctrine fundamental founding concepts, emphasizing his role in shaping this doctrine, as he was also Israels Defence Minister at the time of its creation in 1948. This article will look at the concept of national security conceived by Ben-Gurion, starting with work focusing on the military aspects in the first instance, the nature of the military response in all the conflicts threatening Israel from its Arab neighbors, and finally highlighting the civil perspective underlying all the measures taken to contain the threats.
CRACKS IN THE PILLARS: ASSESSING LIMITATIONS IN THE LEGAL SERVICES AUTHORITY ACT FOR EQUITABLE JUSTICE
Authors:   Research Scholar, Mahatma Gandhi University, Meghalaya., Thaneswar Kalita Shri , Chandra Dash Pratap ,   Supervisor, Mahatma Gandhi University, Meghalaya.
Published: January 2024

This doctrinal research delves into the Legal Services Authority Act, 1987, scrutinizing its effectiveness in fostering equitable justice within the Indian legal system. Unraveling the historical context and key provisions, the study critically examines its impact, identifies limitations, and proposes innovative solutions. Navigating through literature, cases, and legal papers, the research pioneers a discourse on the challenges impeding the acts implementation. Crafting a roadmap for the future, the paper concludes with a compelling call to action for stakeholders and legal policymakers, emphasizing the imperative of achieving true equitable justice.
STUDIES ON THE FLORISTIC DIVERSITY OF PUTHUKULANGARA KAVU, PAYYANNUR, KERALA, INDIA
Authors:   Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, Mahatma Gandhi Govt. Arts College, Mahe, U.T. of Puducherry., K. Jeena , Kumar G. Pradeep ,   Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, Mahatma Gandhi Govt. Arts College, Mahe, U.T. of Puducherry., K. Sasikala ,   Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, Mahatma Gandhi Govt. Arts College, Mahe, U.T. of Puducherry., Kumar E. Girish ,   Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, Mahatma Gandhi Govt. Arts College, Mahe, U.T. of Puducherry., M.E Anushree ,   Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, Mahatma Gandhi Govt. Arts College, Mahe, U.T. of Puducherry.
Published: January 2024

Maintenance of high level of biodiversity is essential for the stability and sustainability of an ecosystem. In natural habitats, the biodiversity represents an important pool of species and genetic material having immense potential use to human society. The floristic diversity of the Puthukulangara Kavu, situated in Karivellur - Peralam Grampanchayath of Payyannur Taluk, Kannur District and Kerala state was surveyed. A total of 108 plant species were recorded. Of this, 98 species belonging to 92 genera and 49 families constituted angiosperms. In addition, Gymnosperm and Pteridophytes were represented by one species each, Bryophytes and Fungi with 4 species each were recorded.
SUB-MINUTE CAPILLARY ZONE ELECTROPHORESIS METHOD FOR DETERMINATION OF HYDROCHLOROTHIAZIDE IN COMBINATION WITH OTHER ACTIVE INGREDIENTS IN NINE DIFFERENT PHARMACEUTICAL SAMPLES
Authors: Marra Mariana , Munoz Rodrigo , Richter Eduardo
Published: January 2024

Capillary electrophoresis (CE) methods have unique potential for applications in quality control of pharmaceutical formulations. Here, we show that a single and ultra-fast CE method can be used for the determination of hydrochlorothiazide (HCT) in combination with nine other active ingredients in a single run in different pharmaceutical samples: atenolol (ATE), metoprolol (MET), propranolol (PRO), benazepril (BEN), captopril (CAP), enalapril (ENA), lisinopril (LIS), ramipril (RAM), and valsartan (VAL). This goal was achieved using a single and simple background electrolyte (BGE) composed of 10 mmol L-1 of boric acid with pH adjusted to 9.0 with sodium hydroxide. All samples can be analyzed in less than 1 min with the attainment of good analytical performance, such as high-resolution separation (r > 1.3), low sample and reagents consumption (environmentally friendly method), low relative standard deviation (RSD) values for peak area (< 4.0%) and migration times (< 1.7%), and linear relationships with good correlation coefficients (> 0.995). Furthermore, recovery tests showed good results (100 ± 5%) for all evaluated compounds.
Potential impact of food inflation on households’ welfare: Evidence from Pakistan
Authors:   The University of Agriculture Peshawar, Ullah Irfan , Uçak Harun ,   Alanya Alaadin Keykubat University
Published: January 2024

The global food price crises of 2007–2008 and the recent resurgence of food inflation have gained attention of the researchers about the causes and consequences of this volatility in food prices around the globe. This paper aims to examine the potential impact of food inflation on households’ welfare in Pakistan. For this purpose, the authors used a flexible Linear Approximate Almost Ideal demand System (LA/AIDS) to estimate the food demand pattern using the recently available Household Integrated Economic Survey of Pakistan for the year 2018–2019. Food products were categorized into thirteen food groups including milk, meat, fruits, vegetables, sugar, beverages, cereals, wheat, rice, oil & fats, tea, condiments and baked products. The estimated model was used to simulate different price increase scenarios in each of the currently own price. We found out that the estimated loss in the consumption was consistently high for milk, sugar, cereals, rice, wheat, meat and oil & fats. The issue of limited diversity in the dietary pattern and persistently food inflation will result in alarming food security in the country. The Effect of an increase in the general price level on food consumption could only be reduced by enhancing households’ purchasing power in the current scenario. The outcome of this research study will help policymakers in the agriculture sector to develop reliable and sound policy designs that will help control the implications of food inflation on household welfare loss.