bluuebunny/crossref_metadata_2025 huggingface dataset:
Off-the-shelf vasculature: Biofabrication of compliant decellularized vascular grafts
Authors:   , Weekes Angus
Published: July 2024

Regenerative medicine is a promising approach to produce vascular grafts for treatment of cardiovascular disease. However, current small diameter tissue-engineered vascular grafts (TEVGs) possess unsuitable mechanical properties, reflected by low patency rates in vivo. In this thesis, TEVGs were biofabricated using biomimetic melt-electrowritten (MEW) tubular scaffolds as substrates for cell culture. Through dynamic culture, TEVGs developed collagen-rich extracellular matrix and physiological mechanical performance. TEVGs were successfully decellularized, toward the development of non-immunogenic off-the-shelf products.
Pembelajaran Matematika Melalui Media Game Quizizz Untuk Meningkatkan Hasil Belajar Siswa
Authors: Dermawan Dwi Ardy , Ramadhan Alfitrah
Published: July 2024

The advancement of science and information and communication technology as one of the products of changing times has had a positive impact on the progress of today's education world. The era of digitalization called the era of the industrial revolution 4.0 made changes very quickly. Many digital learning applications can be used effectively and efficiently as learning support media. This research requires learning media innovation so that students do not feel bored during the teaching and learning process. Many digital learning applications that can be used effectively and efficiently as learning support media The purpose of this research is: to find out the increase in student learning outcomes in the VIIIath Pythagorean theorem material at SMPN 2 Bojonegara. This type of research is Classroom Action Research (CAR). Data collection using the test and observation methods from January to February 2020. The results of this study are; there is an increase in learning outcomes on average learning outcomes 63 in cycle I and 78 in cycle II.
MICROBIAL ECZEMA, ASSOCIATED WITH KLEBSIELLA PNEUMONII AND STAPHYLOCOCCUS EPIDERMIDIS (Clinical case)
Authors: ShAN'ShIN S.
Published: July 2024

Microbial eczema is a chronic recurrent dermatosis characterized by evolutionary polymorphism of the rash elements, weeping, itch, and a peculiar allergic reaction of the sensitized skin to the decay products and toxins of microorganisms. The article cites a clinical case of microbial eczema with an atypical causative agent – Klebsiella pneumonii combined with Staphylococcus epidermidis
DUAL-ENERGY RADIOGRAPHY IN THE DIAGNOSTICS OF THE THORACIC DISEASES: PROSPECTIVE STUDY
Authors: VASIL'EV A. , NAUMOVA D. , NEChAEV V.
Published: July 2024

The article demonstrates capabilities of the dual-energy radiography to identify most frequent radiological symptoms of the pathology of thoracic organs and bone structures
Crateús ComCiência: Ciência Cidadã, Extensão Universitária e Formação Profissional
Authors: Nascimento Edilane Ribeiro do , Rodrigues Marcos Paulo Lopes , Moura Francisco Nunes de Sousa , Paiva Aparecida Barbosa de , Holanda Deborah Ximenes Torres , Sousa Shirliane de Araújo , Menezes Jones Baroni Ferreira de
Published: July 2024

A extensão visa realizar uma troca de conhecimento entre a comunidade e a universidade. Nesse aspecto, o projeto Crateús ComCiência é desenvolvido em uma instituição de ensino superior em Crateús/CE, buscando exercer esse papel dentro do contexto educacional. Assim, objetiva-se neste artigo compreender o impacto do projeto na formação profissional dos discentes participantes. Com a aplicação de um formulário eletrônico, buscou-se responder indagações pautadas na contribuição deste para a formação acadêmica dos partícipes. O projeto foi descrito como interdisciplinar pelos pesquisados, refletindo uma das bases do projeto, ao incluir discentes dos variados cursos e semestres. Quanto à importância, relataram sobre o desenvolvimento de habilidades tanto no profissional como no pessoal. Este fato condiz com a extensão por ser uma experiência de troca, onde não somente os receptores são beneficiados, mas como quem está passando o conhecimento. Com isso, é possível perceber que o projeto exerce papel fundamental para eles.
Penggunaan Media Pembelajaran Aplikasi Quizizz pada Masa Pandemi Di SMK N 5 Palembang
Authors: Kushendratno Kushendratno
Published: July 2024

This article aims to illustrate how to use Quizizz as a learning tool. This article is a study of the literature, including references to books, journals, and Internet postings. This article explores how the Quizizz application can generate creative, innovative, and interesting learning media, and why educators should use it as a learning tool, particularly during the pandemic of Covid-19.
The Effect of Digital Literacy and Motivation on Teacher’s Performance
Authors: Nugraha Filipus Chinmi Adin , Ahyani Nur , Rohana Rohana
Published: July 2024

This research aims to know and examine: (1) The effect of digital literacy on teacher performance; (2) The effect of motivation on teacher performance; and (3) The effect of digital literacy and motivation together on teacher performance. This research is quantitative research with an ex post facto approach. This research was conducted in public and private junior high schools in Ilir Timur 1 Palembang District with a population of 240 teachers, and a random sample of 150 people was taken. The data collection technique used a questionnaire. The validity test uses construction validity and content validity, while the reliability test uses Cronbach’s Alpha. The analysis requirements test uses normality test, linearity test, multicollinearity test, and heteroscedasticity test, and the data is analyzed using multiple linear regression techniques. The results showed that digital literacy, motivation, and teacher performance can still be said to be sufficient, there is a positive and significant influence between digital literacy and motivation together on teacher performance by 65.2% while 34.8% is determined by other factors not mentioned in this study.
The Effect of Principal’s Leadership and Organizational Justice on Elementary School Teacher’s Performance
Authors: Wistiany Rahma , Arafat Yasir , Rahman Andi
Published: July 2024

Because of a phenomenon he noticed in earlier researchers’ work and the empirical finding that principal leadership and organizational justice affect teacher performance, the author was inspired to conduct this study. To better understand how these two factors affect the performance of State Elementary School (SD) teachers in Cluster 1 Koba District, Central Bangka Regency, Bangka Belitung Islands Province, the author conducted this study. application of quantitative research techniques. 84 instructors from 8 public elementary schools located in Cluster 1 made up the sample, which was determined using random sampling. Koba District. By distributing questionnaires with a Likert scale of 1 to 4, the data were collected. The SPSS-26 program was used to statistically process the data. The outcomes of the data analysis support the finding that organizational justice and the principal’s leadership have a favorable and significant impact on teacher performance, either separately or collectively. According to the coefficient of determination test, organizational fairness and the principal’s leadership had a combined 52.2% effect on teacher performance.
Designing of Stable Co-crystals of Clotrimazole using suitable Coformers
Authors: Prabhu Nishank , Pooja Srinivas Poojary , Ravi Gundawar , Pai Aravind , Pai Girish , Pai Vasudev , S.G. Vasanthraju , Sathyanarayana Muddukrishna Badamane
Published: July 2024

The present study involves the preparation of co-crystal forms of clotrimazole with co-formers namely nicotinic acid and naringenin. Clotrimazole is a BCS class II drug withlow solubility and high permeability. Hence by preparing the co-crystal, an attempt has been made to improve its solubility. Based on thehydrogen bond formation between the API and co-former, two co-formers were selected: nicotinic acid and naringenin. The co-crystals of clotrimazole with nicotinic acid and naringenin were prepared in the molar ratios of 1:1, 1:2, and 2:1 using dry grinding and solvent evaporation. PXRD, DSC and FTIR confirmed the formation of co-crystals. The solubility of co-crystals of clotrimazole with nicotinic acid was increased 2.07 folds for the ratios 1:2 prepared by solvent evaporation method compared to pure clotrimazole. The saturation solubility was also increased for the co-crystals of clotrimazole with naringenin by 2 folds for the ratio 2:1 prepared by solvent evaporation method compared to pure clotrimazole.
Exploring the Biofilm Inhibiting potential of Bunium persicum Essential Oil: A Promising Strategy for Combating Microbial Biofilm
Authors: A. Sawarkar Hemant , C. Kale Sachin , D. Bawankar Ram , R. Biyani Kailas
Published: July 2024

This research aimed to investigate the biofilm inhibiting activity of essential oil derived from Bunium persicum and determine its potential as a natural alternative for combating biofilm-related infections. The essential oil from Bunium persicum was extracted using the steam distillation method. The antimicrobial activity of the oil was evaluated using the cup plate method against selected pathogenic microorganisms. The minimum inhibitory concentration (MIC) values were determined to assess the concentration at which the oil effectively inhibited microbial growth. The biofilm inhibitory potential of the oil was evaluated using the micro titer plate assay. The oil exhibited significant antimicrobial activity against Streptococcus mutans, Staphylococcus aureus, Lactobacillus sporogens, Bacillus coagulans, and Candida albicans, as evidenced by the substantial zones of inhibition observed in agar well diffusion assay. The MIC values indicated effective inhibition of microbial growth at a range of concentrations. Moreover, the oil demonstrated remarkable suppression of biofilm formation for all tested organisms in the micro titer plate assay. To the best of our knowledge, this is one of the pioneering studies investigating the biofilm inhibitory activity of essential oil from Bunium persicum. While previous research has focused on the antimicrobial properties of this oil, its potential as a biofilm inhibitor has not been extensively explored.
ФЛОРА ВОДОРОСЛЕЙ НЕКОТОРЫХ ПРИТОКОВ РЕКИ ЧАТКАЛ НА ТЕРРИТОРИИ БЕШ-АРАЛЬСКОГО ЗАПОВЕДНИКА
Authors: Моомбеков Сапарбек
Published: July 2024

В данной статье изложены результаты исследования альгофлоры притоков р. Чаткал, где обнаружено 71 видов водорослей относящихся 4 классам. Флористические исследование водорослей для горных и высокогорных водоемов Кыргызской Республики являются актуальными. Камеральную обработку проб производили в 2 приема. Сначала определяли сине-зелёные, зеленые, жёлто-зелёные, золотистые, динофитовые, красные.  Редкие и новые для Кыргызстана виды при определении зарисовывали аппаратом РА-6 и фото насадкой.  Прозрачность воды устанавливали дискам Секки. Величину рН определяли наборам индикаторов по Михалэису и универсальным индикатором. Видовую принадлежность водорослей определяли с помощью микроскопа МБИ-3 и Оlumpus. Изучение их флоры водорослей позволяет расширить представление о редких, уникальных и ценных видах этих растений, выявить закономерности  их распределения, наметить пути наиболее рационального использования.
A Survey of Fast Charging Systems in Electrical Vehicles using Solar and Grid Sources
Authors: Sandeep Bishla
Published: July 2024

Electric vehicles (EVs) offer green mobility, however, the market for electric cars experiences very low annual growth due to a need for EV charging stations, a drawn-out charging process, and grid variability during periods of high demand. The automotive industry strives to offer clean and adequate fuel-based transportation, and EVs are the best alternatives to conventional Integrated Circuit (IC) engine-based automobiles. Fast charging of EVs is necessary to overcome the main obstacle to EV adoption, which is the length of the charging process. Various solutions have been put forth with the adoption and absorption of fast public charging. With the development of EVs, there is a rising need for charging stations. In the charging station, a many power is needed. The energy required is significantly larger in a Fast Charging Station (FCS). Power loss, Voltage instability, harmonic distortion, and transformer overloading are all effects of the unexpectedly increased demand for electricity in the distribution system. So in this survey, fast charging techniques with two sources, such as grid and solar, were analyzed and discussed. This review paper aims to address a major challenge hindering the widespread adoption of electric vehicles (EVs) - the time-consuming charging process. The article focuses on fast charging techniques using grid and solar power sources. As the demand for EVs increases, the need for charging stations also grows, including the power requirements of Fast Charging Stations (FCS). The paper analyzes and discusses the techniques used in FCS and the pros and cons of utilizing grid and solar power sources. The primary contribution of this work is to assess rapid charging systems that use both solar and grid references, identifying the challenges and issues associated with current EVs. The paper concludes that the development of fast charging systems that incorporate both grid and solar power sources is essential to promote the widespread adoption of EVs and offers a promising solution to the challenges facing the transition to a sustainable transportation system.
Intervensi Keperawatan Fisioterapi Sinar Infrared Dapat Menurunkan Skala Disabilitas Aktifitas Sehari-Hari Pada Pasien Low Back Pain Myogenik
Authors: Widiyono Widiyono , Suwarni Anik , Aryani Atik , Wulansari Agix
Published: July 2024

Low Back Pain Myogenic mengakibatkan penderita mengalami kesulitan beraktifitas dan kesusahan dalam melakukan pekerjaan sehari-hari. Jika Activity day livings (ADLs) terganggu, hal ini akan berdampak pada menurunya kualitas hidup penderitanya. Adapun upaya untuk mengurangi disabilitas pada pasien low back pain myogenic adalah dengan pemberian terapi sinar infra red (IR). Terapi sinar infra red (IR) dapat menghilangkan rasa sakit, meningkatkan suplai darah dan relaksasi otot.Tujuan Penelitian ini adalah untuk mengetahui pengaruh fisioterapi sinar infra red (IR) terhadap disabilitas pada pasien low back pain myogenic. Rancangan penelitian menggunakan quasy experimental dengan pendekatan one group pre and post test design without control. Sampel penelitian berjumlah 20 penderita Low Back Pain Myogenic. Pemilihan sampel menggunakan teknik purposive sampling. Intervensi penelitian yang digunakan yaitu terapi infra red (IR) yang diberikan sebanyak 6 kali selama 2 minggu, pengukuran tingkat disabilitas Low Back Pain Myogenic menggunakan alat ukur berupa kuesinoer Oswestry Disabilirty Index. Analisis data menggunakan uji Paired sample test. Uji statistik dengan uji paired sample test diperoleh nilai rerata tingkat disabilitas pasien low back pain myogenic  sebelum intervensi sebesar 32,1 dan sesudah intervensi sebesar 15,4 dengan selisih 16,7. Hasil nilai p= 0,001 (p<0,05) yang artinya ada pengaruh signifikan tindakan fisioterapi sinar infra red (IR) terhadap disabilitas pada pasien low back pain myogenic secara statistik. Kesimpulan penelitian ada pengaruh tindakan fisioterapi sinar infra red (IR) terhadap terhadap tingkat disabilitas pada pasien low back pain myogenic di RSU Fitri Candra Wonogiri.
Hubungan Komunikasi SBAR Handover Dengan Kepuasan Kerja Perawat Di RSUD
Authors: Handayani Tuti , Hasanah Nur , Wargiah Wargiah
Published: July 2024

Komunikasi SBAR saat pelaksanaan handover masih dijumpai kurang disiplin. Komunikasi SBAR tidak dilengkapi dengan mendokumentasikan keadaan baru, namun mengikuti keadan lama. Sistematis pelayanan ke pasien tidak berkurang, namun dalam pencatatan di SBAR kurang update jika tidak dilakukan sistematis SBAR setiap overan. Tujuan penelitian ini adalah mengetahui hubungan penerapan komunikasi SBAR saat handover dengan kepuasan kerja perawat di RSUD Demang Sepulau Raya Kabupaten Lampung Tengah tahun 2023. Jenis penelitian yang diguanakan adalah kuantitatif dengan design penelitian analitik dan pendekatan cross sectional. Populasi dalam penelitian ini sebanyak 150Â  perawat, dengan perhitungan sampel didapatkan sebanayk 60 perawat sebagai responden. Teknik pengambilan sampel dengan cluster random sampling. Penelitian dilakukan dengan menggunakan kuesioner yang dibagikan kepada responden. Analisa data menggunakan uji chi square. Hasil analisa menggunakan uji statistic chi-square didapat p-value 0,000 (p <0,05), hal ini menunjukan bahwa ada hubungan penerapan komunikasi SBAR saat handover dengan kepuasan kerja perawat. Perawat diharapkan meningkatkan pelaksanaan dan penerapan komunikasi SBAR saat handover sehingga dapat meningkatkan kepuasan kerja perawat. Rumah Sakit dapat memberikan in house training penerapan komunikasi SBAR saat handover dalam meningkatkan kualitas pelayanan kesehatan
Kajian Kebijakan Stategis Dalam Pencegahan Stunting Di Kabupaten Keerom Provinsi Papua
Authors: Manangsang Frans , Rumaseb Ester , Purba Ellen R.V , Swastika I Ketut , Nuburi Dorci
Published: July 2024

Terjadi peningkatan akses layanan kesehatan dan partisipasi masyarakat dalam pencegahan stunting di Wilayah Papua, akan tetapi tantangan signifikan terdapat pada keterbatasan infrastruktur, kekurangan tenaga kesehatan, isolasi geografis, dan hambatan budaya dalam pencegahan stunting. Tujuan penelitian yaitu mengevaluasi kebijakan strategis dalam pencegahan stunting di Kabupaten Keerom, Provinsi Papua, dengan menyoroti intervensi gizi spesifik dan sensitif, serta kampanye edukasi yang telah diimplementasikan. Metode penelitian yang digunakan yaitu studi kasus dengan mengkaji kebijakan penanganan stunting. Pengumpulan data dilakukan dengan fokus group discussion dan round table discussion. Analisis data menggunakan metode kualitatif dan kuantitatif. Hasil penelitian menunjukan bahwa kebijakan strategis dalam pencegahan stunting di Kabupaten Keerom, Provinsi Papua, telah mencakup intervensi gizi spesifik dan sensitif, serta kampanye edukasi yang efektif dalam meningkatkan kesadaran masyarakat tentang pentingnya gizi seimbang. Meskipun demikian, penelitian mengidentifikasi tantangan utama yang menghambat efektivitas kebijakan tersebut, termasuk keterbatasan infrastruktur, kekurangan tenaga kesehatan, dan isolasi geografis. Selain itu, kebiasaan budaya lokal juga memainkan peran dalam menghambat penerapan praktik gizi yang baik. Untuk meningkatkan efektivitas kebijakan ini, rekomendasi yang diberikan meliputi peningkatan infrastruktur, penambahan dan pelatihan tenaga kesehatan, serta penyesuaian pendekatan kampanye edukasi yang lebih sesuai dengan konteks budaya lokal.
Pelatihan Pertanian Organik dan Pembuatan Eco-Ezyim Serta Biopestisida : Solusi Mengatasi Dampak Karhutla
Authors: Supriati Lilies , Jaya Adi , Veronica Evi , Uda Saritha Kittie , Zubaidah Siti , Mulyani Rahmawati Budi , Saragih Osi Karina , Subianto Pratiwi , Adventa Alma , Page Susan E. , Upton Caroline
Published: July 2024

Kegiatan pengabdian kepada masyarakat dilaksanakan di Kelurahan Tumbang Tahai, Kecamatan Bukit Batu.  Sasaran kegiatan pengabdian ini adalah kelompok tani yang menginginkan tentang pertanian organik, karena sebagian masyarakatnya berkeinginan terbentuknya kelompok pertanian organik.  Tahapan pelaksanaan diawali dengan ceramah dan diskusi tentang pertanian organik, pelatihan pembuatan eco-enzim, pelatihan pembuatan biopestisida PGPR, dilanjutkan dengan pendampingan cara aplikasi pupuk organik kompos dan PGPR pada tanaman mentimun mitra.  Hasil kegiatan pengabdian kepada masyarakatnya dapat terselenggara dengan lancar, mendapat respon positif dan mitra sangat antusias mengikuti kegiatan ini.
Pengaruh Back massage terhadap Kualitas Tidur Ibu Hamil Trimester III di Praktik Mandiri Bidan Dince Syafrina Kota Pekanbaru
Authors: Yanti Yanti , Deswita Afriyeni  , Susilawati Elly , Rahmadona Rahmadona
Published: July 2024

Sleep disturbances are one of the discomforts of third-trimester pregnant women that affect the quality of sleep. One of the non-pharmacological methods to help reduce sleep disturbances is back massage. The study aimed to determine the effect of back massage on third-trimester pregnant women's sleep quality. This type of research was pre-experimental, using the One Group Pretest Posttest Design approach. The population in this study was a third-trimester pregnant woman who checked her pregnancy at PMB Dince Safrina Pekanbaru City in February-March 2023. The sample in this study amounted to 15 pregnant women in the third trimester who had a PSQI score > 5, which was taken by purposive sampling. The data collection method was observation using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The results showed that the average sleep quality of pregnant women before the intervention was 7.67 (Sd = 1.34), and the average sleep quality after the back massage intervention. 5.73 (Sd = 0.69). Based on statistical tests, back massage affected the sleep quality of pregnant women in the third trimester (pvalue= 0.001). It is expected that health workers, especially midwives at PMB Dince Safrina, can apply back messaging as a non-pharmacological therapy for treating sleep disorders in third-trimester pregnant women.
Analysis of sustainable tourism practices and sustainability reports of environmentally friendly five star hotels in Antalya destination
Authors: Türkay Bahar
Published: July 2024

Sustainable and sensitive practices in the hotel industry have an important place in ensuring sustainability in tourism. These applications are in a wide range covering many dimensions such as energy management in hotel businesses, renewable energy applications, environmentally friendly accommodation business applications, carbon footprint, blue flag, and biodiversity protection. Efficient use of energy, water, and natural resources, benefiting from solar energy, reducing waste and environmental pollution, zero waste, healthy interior, and exterior decorations, preserving the balance of nature with green building, and all practices aimed at protecting natural resources are among the dimensions that show sustainable practices in hotel businesses. In this sense, hotel businesses in Turkey, which are described as environmentally friendly accommodation businesses, report their sustainability efforts along with current developments and share various sustainability practices on their websites. Some of the businesses that include different dimensions and studies in their sustainability reports reflect these studies on their websites and make them accessible to consumers under the "sustainability" heading on their websites. Considering that websites are an important digital marketing tool, using this tool up to date and creating a sustainable policy supported by technological developments will make these policies more permanent. This study aims to examine the sustainability-related posts and sustainability reports on the websites of five-star and environmentally friendly hotels in the Antalya destination, taking into account the 2030 Sustainable Development Goals of the United Nations, to identify sustainable tourism practices through their websites and to present a comparative analysis.
Produtividade e valor nutricional de silagens de sorgos normais e mutantes BRM
Authors: Moura Marielly Maria Almeida , Monção Flávio Pinto , Pires Daniel Ananias de Assis , Lima Maria Clara Chaves , Madureira Mariana Rabelo , Silva Leandra Cristina Soares , Pires Neto Otaviano de Souza , Costa Renê Ferreira , Castro Sabrina Gonçalves Vieira de , Nogueira Isadora Alves , Versiani Ana Ariela Gusmão , Dias Júnior Carlos Antônio , Santos Keitty Fabiany Alves , Araujo Isadora Vieira Santos , Mizobutsi Edson Hiydu , Santos Adriane Stefany Batista dos
Published: July 2024

O sorgo é o 5° cereal mais produzido no mundo, levando esforços dos pesquisadores na obtenção de um maior número de variedades e híbridos, resultando em silagens com diferentes qualidades. O objetivo deste trabalho foi avaliar a produção de massa e o valor nutricional de silagens de diferentes genótipos de sorgo. Foram utilizados 14 genótipos de sorgo forrageiro (7 normais e 7 mutantes brm), seguindo um delineamento inteiramente casualizado. Esses dados foram submetidos à análise de variância em modelos mistos, utilizando o procedimento MIXED do SAS. Os genótipos mutantes brm apresentaram produção de massa verde (P < 0,01) e número de florescimento 28,7% e 9,5% superior aos genótipos normais. Para as características fermentativas das silagens de diferentes genótipos não foi encontrada diferença nos valores de pH (média 4,2; P = 0,50). Para os valores de composição química não foi observada diferença significativa para os teores de MS (21,2%; P = 0,24), FDN (66,1% MS; P = 0,46), FDA (35,8% MS; P = 0,56), lignina (4,8 % MS; P = 0,11), hemecelulose (30,4% MS; P = 0,96), celulose (31% MS; P = 0,79) e CT (77,5% MS; P = 0,57). Entretanto, as silagens de sorgo dos genótipos brm apresentaram PB médio 6,8 unidades percentuais inferior às silagens de sorgo normais (13,28%; P = 0,01). Genótipos de sorgo mutante (brm) para produção de silagem apresentam maior potencial de produção de massa seca por unidade de área, além de melhor valor nutricional da forragem ensilada em relação às silagens normais de sorgo.
Combining PD-1/PD-L1 and CTLA-4 inhibitors for the treatment of colorectal cancer: A systematic review and meta-analysis
Authors: Fan Xiaolu
Published: July 2024

Objective: The objective of this study is to evaluate the effectiveness of employing both PD-1/PD-L1 and CTLA-4 inhibitors in the treatment of cancer, with a specific emphasis on colorectal cancer (CRC). Approaches: A methodical search of internet databases was performed to discover pertinent studies. The eligible studies included those that examined the management for those had colorectal cancer with the combined medications. Afterwards, the pertinent indicators were computed. Results: Eight publications were included in the study, and they provided data on the objective response rate, disease control rate, progression-free survival rate, and overall survival rate. The reported rates were 64.6%, 82.68%, 64.60%, and 73.11%, respectively. Conclusion: The findings of this investigation suggest that using both PD-1/PD-L1 and CTLA-4 inhibitors together is of great development potential when treating CRC with mismatch repair errors. Additionally, the treatment-related side effects are manageable.
Role of Gut Microbe in Cancer Immunotherapy
Authors: Wang Shiyu
Published: July 2024

Gut microbes have become more and more popular as their balance is closely related to human health and immunity. The gut has its own mucosal structure which helps prevent pathogenic bacteria from invasion and working with gut microbes to deal with diseases. The gut microbe can affect human immunity through its metabolite and its connection with the mucosal system. They can also help build barriers to prevent hosts from the pathogens. While the dysregulation of gut microbe will cause inflammation, diseases, and tumor growth. The growth of pathogens and the drop of probiotics destroy the function of the host’s immunity and thus result in some gut diseases, such as autoimmune diseases and colorectal cancer. Also, clinical trials have shown that the gut microbe has a great effect on cancer immunotherapy, especially immune checkpoint inhibitors. Research has proved many kinds of bacteria in the human gut can help regulate and promote the blocking of common immune checkpoints like CATL-4. They can take part in cancer immunotherapy by their secretion to trigger the human immune system and help patients deal with tumors as well. Here the structure of the gut immune system, the common gut diseases, and the roles played by gut microbes in them are discussed. Also, the link between gut microbe and cancer immunotherapy will be included. Finally, the challenges and future development of the gut microbe in cancer treatment are briefly mentioned.
A Study of Utilizing Social Media for Luxury Brand Promotion
Authors: Li Jiakun
Published: July 2024

With the development of the times and the increasing popularity of the Internet, the traditional market has long since ceased to be the main track for the promotion of luxury brands. Nowadays, social media has profoundly changed people's daily behavior throughout all their daily lives and has also profoundly changed the way luxury brands market today, becoming the spring of luxury marketing. This paper discusses how luxury brands utilize social media for product promotion. Using the PEST framework to analyze the macroenvironment affecting the luxury industry, it introduces the types of promotional strategies on social media platforms and analyzes the study through a successful case study of the current application by LVMH Group. The research results show that there are a series of challenges and opportunities in the promotion of the luxury market on social media. Given the lack of integration of digital and physical outlets, the research suggests that luxury brands strengthen the deep integration of web-based and brick-and-mortar platforms, enhance the shopping experience by directly linking online malls, and set up digital displays and fitting areas to increase sales conversion rates and better meet consumers' shopping needs. In addition to facing the risk of brand popularization, luxury brands need to pay attention to brand uniqueness and high-end image, maintain excellent quality of product design and marketing strategy, emphasize the traditional craftsmanship and historical pedigree of the brand, attract customers who truly understand and value the luxury culture, and carefully choose partners and promotion channels to maintain the high-end reputation and unique charm of the brand.
Challenges In County Economic Development in China: A Case Study of Huan Xian
Authors: Wang Jiayao
Published: July 2024

County is one of the basic units of China's economy. An in-depth understanding of the county economic development situation is helpful to grasp the overall trend of China's economy, and to provide a foundation for the government to formulate policies and allocate resources more effectively. The key to the realization of rural revitalization strategy lies in the development of county economy. Through the study of county economy, local people can find out the effective ways and methods to promote rural revitalization, promote the transformation and upgrading of rural economy, and realize the sustainable development of economic and social development. Huan Xian is a representative of the counties in Northwest China. By studying the economic development strategies of Huan Xian, this paper analyzes the current advantages and challenges, and evaluates the characteristic policy "sheep +" that has been implemented by the local government. Suggestions are put forward to establish a market information sharing platform and pay attention to ecological protection, so as to make a contribution to the development of the Western China.
Maternal And Child Health Study Based on Decision Tree and Partial Least Squares Regression
Authors: Xu Risheng
Published: July 2024

The physical and mental health of mothers plays a crucial role in the development of infants. In this paper, the influence of mothers' physical and mental indicators on infants' behavioral characteristics, the comprehensive sleep quality assessment system, and the treatment plan for mental illnesses are studied in depth. First, the decision tree model is used to explore the relationship between mothers' physical and psychological indicators on infants' behavioral characteristics. Second, a linear programming model was developed between the degree of illness and the scores of the three psychological indicators to derive the minimum cost of the mother's psychotherapeutic program that can change the infant's behavioral characteristics. Finally, the infant sleep quality indicators were graded, the weights of each sleep quality indicator were calculated using AHP hierarchical analysis, and the formula for calculating the sleep quality grade was derived using a partial least squares regression model. The study in this paper evaluates the physical and psychological indicators of mothers in a scientific way, thus ensuring the quality of mother-infant interaction.
A Study of Tennis Momentum Based on Markov Chains and Lgbms
Authors: Xie Yilan
Published: July 2024

The heightened focus on competition has captured people's attention, elevating the significance of athletic endeavors. This study aimed to explore the effects of changes in sports competition. Through data preprocessing and principal component analysis, 13 factors influencing posture were confirmed and dynamic expressions were derived to measure athlete performance using entropy weighting. We further investigated the effect of competition fluctuations on the performance of future athletes, revealing the close relationship between situation size and subsequent scoring. Specifically, we used two methods, Markov Chain and Light Gradient Boosting Machine (LGBM), to predict match swings. Overall, this study deeply dissected the dynamic changes in athlete performance, reveals the interaction between posture and athlete outcomes, and provides practical suggestions for optimizing athlete status and competition strategies.
Research and Thinking Based on Credit Suisse Bank Crisis
Authors: Yin Mengli
Published: July 2024

In view of the acquisition of the global systemically important bank Credit Suisse, this paper objectively describes the beginning and end of the crisis of Credit Suisse, focuses on the analysis of the difficulties faced by Credit Suisse before the acquisition, the reasons behind and the impact on the financial market, and carries out deeper thinking and analysis. First, it provides reference for the development of banking industry and risk prevention and control; Secondly, strengthening the importance of bank risk management; Finally, it provides some feasible suggestions for the stability of financial market.
Research on Supplier Development Strategy Considering Spillover Effect in Competitive Environment
Authors: Cui Guodong
Published: July 2024

Aiming at the optimal investment strategy of the manufacturer to the supplier, considering the film stars brought by the spillover effect in the investment process, the profit, investment level and the impact on the supply chain members of the manufacturer under the three investment strategies are studied. It is found that: (1) As long as the manufacturer invests, the profit obtained under the three investment strategies is always higher than that without investment and investment is always beneficial to suppliers; (2) In the case of one manufacturer's investment, the equilibrium solution of the manufacturer under three investment strategies is analyzed, and it is found that the investment manufacturer is more willing to invest in the supplier's portfolio; (3) When the manufacturer 's investment ability is high, the profit of non-investors may be higher due to the spillover effect, and the investment manufacturer will gradually reduce its investment level.
Conflicts and Struggles in the Shadow of Colonialism: A Corpus-based Study of Address Terms in Gurnah’s Paradise
Authors: Li Fangfang , Li Junjie
Published: July 2024

This paper employs a research methodology based on corpus linguistics, utilizing the corpus retrieval software AntConc focusing on the address terms in Abdulrazak Gurnah's novel Paradise. It's found that under the shadow of colonialism, conflicts become inevitable and pronounced. Even though, amid various conflicts, the colonized individuals with different races, religions, and identity backgrounds are not deeply entrenched in conflicts. Instead, they choose to struggle for survival, love and belief. The coexistence of cruelty and warmth, opposition and harmony, conflicts and struggles collectively shapes the complex and diverse socio-cultural situation in the region under colonial shadows.
Beneficiaries of educational technology in universities ——A Study on the Equity of Urban and Rural Education in Henan Province
Authors: Shi Yaning
Published: July 2024

The research in this paper combines educational equity and educational technology, based on the theory of educational equity and the theory of stages of educational equity, with the aim of exploring the use of educational technology in rural and urban schools in Henan Province, both during and after the teaching programme. From the perspective of retrospective research, this paper used the questionnaire survey method to survey five colleges and universities in Henan Province, with a total of 203 students; and the semi-structured interview method to interview nine students, four teachers, and two leaders of the Education Bureau. The results of the study show that there is a disproportionate difference in the allocation of basic education resources between rural and urban schools, an unbalanced distribution of education funds, and different levels of importance attached to educational technology by teachers. In addition, students' information literacy skills and family economic status are factors that affect equity in educational technology between urban and rural areas in Henan Province. In view of the current problems, the state, schools and other subjects should promote urban-rural education equity in the system, guarantee urban-rural education equity in the funding, and cultivate information technology talents in the concept to promote the equitable development of urban-rural education technology.
Cancer prognosis prediction models based on deep learning
Authors: Sun Chengyu
Published: July 2024

Cancer is a hot issue that more and more people are concerned about at present. In recent years, the incidence of cancer in the world has been rising, but the treatment methods for cancer have been lacking in specificity. Some researchers have proposed the use of deep learning algorithms to assist cancer treatment, which can be analyzed according to the characteristics of patients, and has made progress in the prediction and treatment of a diverse of different cancers. However, there are few articles summarizing the application of deep learning in cancer prognosis. Therefore, this paper summarizes some advances in deep learning in the field of cancer prognosis in recent years, and discusses the limitations of deep learning and possible future development directions. The research believes that the current limitations of deep learning mainly come from the characteristics of data sets and algorithms themselves, and proposes their own solutions to the problems.
Comparative Analysis of Lazada and Shopee E-commerce Firms in Southeast Asia: Alibaba Strategies for Competing in the Regional Market
Authors: Qiu Qiaoying
Published: July 2024

This thesis aims to compare Lazada with Shopee, a Southeast Asian e-commerce enterprise, to assess the efficacy of Alibaba's strategies for entering and succeeding in the Southeast Asian e-commerce sector. Within this thesis, It gives an in-depth analysis of the current state of e-commerce in South East Asia. Due to its diversified consumer behaviors and specific commercial constraints, this region has recently emerged as a worldwide focal point for digital commerce. Alibaba, the world's largest e-commerce company, is a significant Southeast Asian player through its subsidiary Lazada. However, local e-commerce businesses may provide unique perspectives and approaches based on location. This research examines the similarities and differences between Lazada and regional e-commerce competitor Shopee to identify the primary market forces in each firm's practice in the industry. The study compares and contrasts the two kinds of online retailers by looking at how each one approaches the market, handles logistics, and interacts with customers in Southeast Asia. The research provides a framework of best practises, actionable insights, and recommendations by identifying the strategies that have allowed Alibaba's success in Southeast Asia and comparing them to those adopted by local companies.
Research on Joint Venture Transformation in China's Automobile Market under the New Energy Trend
Authors: Zhang Yuhui
Published: July 2024

In recent years, the rapid development of China's automobile market has made its self-developed automobile enterprises gradually erode the market share, and foreign joint venture automobile enterprises are facing the dilemma of transformation. The purpose of this paper is to study the transformation strategies of foreign joint ventures in China's new energy vehicle market, analyze how they respond to competition from local Chinese car brands, and explore the key factors for foreign firms to regain their position in the Chinese market. By analyzing the development status of China's new energy vehicle market and the challenges faced by foreign brands, this paper puts forward the analysis of the response measures of foreign enterprises, including price reduction strategy, technology research and development and market strategy. Foreign brands face severe challenges in the Chinese market, but there are also opportunities for transformation and adaptation. Localization strategies are crucial in product pricing, marketing strategies, and sales channel management. Foreign enterprises need to shorten the decision-making chain, speed up the market response, and realize the change of organizational structure. Therefore, the conclusion of this paper is that the strategic transformation of foreign automobile enterprises needs to flexibly respond to market changes and learn from the practices of local Chinese brands, especially in the field of new energy vehicles. Foreign enterprises need to constantly observe the changes in the demand of the Chinese market and constantly optimize their product and market strategies to cope with the fierce competitive environment.
Evaluating Audience Attitudes Towards Chinese National Orchestra Concerts
Authors: Lin Yuanhang , Tham Jacquline
Published: July 2024

This study aims to assess audience attitudes towards Chinese National Orchestra concerts. Quantitative research methodology was adopted, and the sample was determined using convenience sampling, with 514 Chinese National Orchestra concert consumers in China selected as the study sample through an online questionnaire. The questionnaire consisted of five questions and was scored on a 5-point Likert scale with a reliability of 0.918. Descriptive analysis was used to analyses the data. The results confirmed that the overall attitude of the audience towards national orchestra concerts was moderate. A pleasant experience is the most prominent manifestation of positive audience attitudes. This therefore provides valuable input for managers to develop and implement strategies to encourage consumers to purchase tickets to go to National Orchestra concerts.
Disney's Approach to Racial Representation: Superficial Changes or Genuine Cultural Engagement?
Authors: Huang Zhenqi
Published: July 2024

This paper explores Disney's approach to racial representation in its films, focusing on whether changes are superficial or reflect genuine cultural engagement. Using Stuart Hall's theory of encoding and decoding, this study examines the impact of character changes in "The Little Mermaid" (2023) on cultural representation.
Genetic Algorithm and LSTM Based Approach for Diver Search and Path Prediction
Authors: Liu Xiangyang , Wang Zhengyang , Xiong Jintong , Liu Zhaoyu
Published: July 2024

With the rapid development of submersible technology, exploring the deep sea is no longer a distant dream. In this paper, a set of safety procedures for manned submersibles is designed to ensure that the main ship can respond in time and launch search and rescue in case of loss of connection. The digital elevation model and Kalman filter algorithm are used to process the deep-sea data, combined with the Monte Carlo method to estimate the position of the submersible, and the water depth of 2000m is taken as the working depth. The genetic algorithm is used to optimize the SAR strategy, and environmental factors are considered to affect the sailing speed. For the case of multi-diver lost connection, CNN and LSTM models are combined to predict the 3D path to avoid the risk of collision. These methods will significantly improve the safety of the submersible and the efficiency of search and rescue and promote the sustainable development of deep-sea exploration.
Research on the Relationship between ESG and Financial Indicators in the New Energy Vehicle Industry
Authors: Cao Siqiang
Published: July 2024

In recent years, sustainable development is an important issue for human social progress, which has become a key focus of attention in the capital market. Therefore, the importance of ESG concepts is becoming increasingly prominent in this context. More and more manufacturing firms seeking development which beginning to incorporate ESG concepts into their plans, and the impact of ESG performance on financial indicators is receiving widespread attention. research adopts a case study method, taking different enterprises in the automotive industry as research objects, and elaborates on their impact on profitability, operational ability, and development ability. Research has found that the good environmental performance of ESG is positively correlated with the excellence of financial indicators in automotive companies, providing financial support for the sustainable development of subsequent enterprises. It can be used as one of the indicators for the investing decision. Finally, research provides relevant recommendations from the perspectives of investors, managers, and future development.
Innovation Strategies and Challenges of Enterprise Supply Chain Management in Digital Age
Authors: Zhang Xinyu
Published: July 2024

This paper analyzes the low penetration rate of digital technology, the lack of security of supply chain management and the sustainability of supply chain in Chinese enterprises Insufficient challenge. In order to cope with these challenges, it is necessary to consolidate the foundation of digital hardware and software and improve the application level of digital technology. Strengthen enterprise data and communications Security protection of interest assets; Increase capital investment, node enterprises to promote the digital transformation of supply chain upstream and downstream and other countermeasures. Finally, the Internet of Things and big data are proposed Analysis, supply chain digital collaboration platform, intelligent warehouse management and supply chain financial services and other innovative ways to meet the supply chain management in the context of enterprise digital transformation requirement.
Research on the Current Situation and Development of Chinese Market and Brand Marketing of Sports Events under the Perspective of Fan Economy: Taking NBA as an Example
Authors: Hu Jialin , Li Jiaxuan , Shi Wenghan
Published: July 2024

In the 1980s, the NBA (National Basketball Association) made its inaugural appearance in China, establishing itself in the Chinese public consciousness. Over the following decades, the NBA gradually evolved into a household name in China, becoming synonymous with basketball. The industrial chain formed around the NBA has also generated significant profits. It is evident that NBA's brand marketing plays a pivotal role in this context. However, in recent years, there has been a decline in the popularity of NBA in China. This phenomenon is complex and is associated with a range of factors, including economic conditions and political perspectives. This study reviews the history of NBA brand marketing in China, the strategies that have been employed. At the same time, this study will combine the interview method to analyze the current image of NBA in the minds of Chinese consumers and point out the current marketing problems of NBA China on this basis. It also combines this with the fan economy to describe the future development direction of NBA brand marketing in China.