bluuebunny/crossref_metadata_2025 huggingface dataset:
THU348 Thyroid Dysfunction And Diabetes In Pregnancy - Is There A Link?
Authors: Kumar Sahay Rakesh , Abdul Kalam Sumayya , Kudugunti Neelaveni , Togarla Srujana
Published: October 2023

Disclosure: R.K. Sahay: Speaker; Self; Novo Nordisk, Roche Diagnostics. S.A. Kalam: None. N. Kudugunti: Speaker; Self; Novo Nordisk. S. Togarla: None.

Background: The Indian subcontinent has shown higher prevalence for both thyroid dysfunction and diabetes complicating pregnancy when compared to the Western population. The association between both has been studied in multiple small studies which have however shown discordant results. Hence the need for exploring this further. Aims: To assess the proportion of women with thyroid autoimmunity and thyroid dysfunction in pregnancy complicated by diabetes mellitus and determine association of the same with diabetes in pregnancy and maternal and perinatal outcomes. Methods: 150 pregnant women with gestational/pregestational diabetes were enrolled in this cross sectional study and the proportion of those with thyroid dysfunction were assessed. Thyroid autoimmunity was evaluated in the same population using antiTPO and anti-thyroglobulin antibodies. The proportion of women with thyroid autoimmunity as well as thyroid dysfunction was calculated and the association of these with diabetes in pregnancy was evaluated along with maternal and perinatal outcomes. The same tests were done on 26 pregnant women without diabetes who served as controls. Results: The mean age of the study population was 26.62 ± 4.34 years. 56% were diagnosed with GDM and the rest had pre-GDM. 26.6% of the study population were diagnosed with hypothyroidism. Of these,45% were newly diagnosed during the current pregnancy. The prevalence of antiTPO antibody positivity was found to be 9.33% whereas that of anti-thyroglobulin antibody was 3.33%. Maternal and perinatal complications were higher in the group with combined endocrinopathy with gestational hypertension and preterm delivery showing statistically significant increase among the latter group. Among those women with combined endocrinopathy who developed gestational hypertension,76.9% had GDM. All of them were found to have subclinical hypothyroidism which was newly diagnosed in third trimester. Conclusion: The prevalence of hypothyroidism in pregnancy complicated by diabetes is higher than the prevalence in normal pregnancy. Undiagnosed subclinical hypothyroidism was found to be strongly associated with development of gestational hypertension. Our study emphasises the fact that women with diabetes in pregnancy should receive early and periodic screening for thyroid dysfunction in pregnancy.

Presentation: Thursday, June 15, 2023
THU355 Tingling Over Cheek, An Atypical Presentation Of Invasive Fungal Sinusitis In An Ambulatory Patient With Type 2 Diabetes
Authors: Udayasankar Jayalakshmi , Vaezeafshar Reza , Patel Natalie
Published: October 2023

Disclosure: J. Udayasankar: None. R. Vaezeafshar: None. N. Patel: None.

A 61 year old female with uncontrolled type 2 Diabetes, A1c over 11% for over 3 years was seen in Diabetes clinic for follow up after a 2 year hiatus. She happened to mention an isolated 1 inch area of tingling over Right (R) cheek. She was previously seen in ED and discharged home on Benadryl. She had also seen an acupuncturist, a dentist and family physician, latter 2 providers treated her with 2 different antibiotics without change in symptoms. She denied fever, headaches, visual acuity changes, diplopia or nasal discharge. Exam in clinic revealed hypoesthesia below eye and towards nasal dorsum, no changes in skin warmth or color noted, eye movements were intact and mild tenderness was elicited on pressure over R maxillary sinus. Atypical presentation of Invasive fungal sinusitis (IFS) was suspected clinically. Seen by ENT and CT and MRI of Sinuses and Orbits showed R maxillary sinusitis, mild enhancement and enlargement of the inferior rectus muscle and infraorbital nerve / foramen present with stranding within the extraconal fat of the R inferior orbit thought to be related to extension of inflammation. Endoscopic sinus surgery showed R maxillary sinusitis with necrotic mucosa along orbital floor and orbital floor dehiscence concerning for invasive infection. Frozen section showed necrotic, inflammatory tissue. Discharged home from ED. Surgical pathology showed necrotic tissue and fungal hyphae with acute angle branching on GMs and PAS stains. Presence of crystals and pigmentation raised possibility of Aspergillus Niger infection. She was readmitted to hospital for repeat surgery - R medial maxillectomy and R pterygopalatine fossa dissection - biopsy of R maxillary sinus walls, right periorbital area and pterygopalatine fossa showed presence of fungal organism. Mold PCR panel showed Aspergillus niger. She received therapy with IV Amphotericin B and was discharged home on Oral Voriconazole. She is doing well and her diabetes control improved on insulin therapy. Patients with uncontrolled Diabetes are immunocompromised and vulnerable to atypical infections that can be potentially lethal if not diagnosed and treated timely. Patient presented with isolated tingling over R cheek for months. Lack of symptom improvement despite two courses of antibiotics and A1c over 11% raised clinical suspicion of IFS . Interestingly frozen path did not reveal hyphae that led to her first discharge from hospital. Surgical pathology and PCR of biopsied material made the diagnosis of IFS - Aspergillus sinusitis and treatment with antifungal medication prevented orbital and cerebral complications of IFS and death. Therefore, awareness of this disease entity in ambulatory patients is important and could be life saving for patients.

Presentation: Thursday, June 15, 2023
FRI641 Assessing Insulin Prescription Adequacy At Hospital Discharge And Its Association With Characteristics Of Diabetic Patients
Authors: Akcan Tugce , Sharma Shivy , Liu Junting , Jayarangaiah Amog , Gilani Muhammad , Surendran Alumparambil , Imamudeen Nasvin , Gabor Rachel , Pathak Ram D
Published: October 2023

Disclosure: T. Akcan: None. S. Sharma: None. J. Liu: None. A. Jayarangaiah: None. M. Gilani: None. A. Surendran: None. N. Imamudeen: None. R. Gabor: None. R.D. Pathak: None.

Diabetes is becoming increasingly prevalent, and appropriate insulin therapy during the post-discharge period is essential to improve glycemic control and reduce readmissions. Despite extensive research on insulin use during hospitalization, little is known about insulin dosing at discharge and patient factors that affect post-discharge needs. Therefore, this retrospective study aimed to evaluate the adequacy of insulin dosing at hospital discharge for diabetic patients and identify patient characteristics impacting post-discharge insulin requirements. Using a retrospective study design, we identified 350 patients meeting the inclusion criteria. The results showed that 19.1% of patients required a decrease in insulin total daily dose (TDD) at follow-up, 50.9% experienced no change, and 30.0% necessitated an increase. Factors found to impact insulin dose adjustments post-discharge include BMI, CKD, discharge TDD, and HbA1c levels. The multivariate analysis revealed that CKD was associated with a decrease in insulin TDD at follow-up (95% CI: -9.65- -0.47, p=0.031). Additionally, insulin TDD at discharge was negatively associated with follow-up dose, with a 0.37 unit decrease (95% CI: -0.44- -0.30, p<0.001) in insulin TDD for each additional unit prescribed. Finally, there was a marginal significance observed in the discharge regimen. Patients on a premixed regimen had a decrease in insulin TDD at follow-up compared to those on a basal-bolus regimen (95% CI: -21.85- 0.27, p=0.057). Our study findings suggest the need for improved estimation of insulin doses at discharge and emphasize the importance of short-term follow-up for insulin titration post-discharge. Patient factors such as body weight, kidney disease, insulin dose at discharge, and HbA1c levels influence these changes. These findings have significant implications for optimizing patient outcomes and reducing hospital readmissions, underscoring the importance of carefully evaluating these factors when tailoring individualized insulin regimens.

Presentation: Friday, June 16, 2023
FRI647 Hemiballismus - A Rare Presentation Of Uncontrolled Diabetes Mellitus Type 2
Authors: Lontoc Macrohon Calvin , Landicho Kanapi Maria Princess
Published: October 2023

Disclosure: C.L. Macrohon: None. M.L. Kanapi: None.

Background: Diabetic Striatopathy is a rare disease with a prevalence of 1 in 100,000 and is more commonly seen in elderly women with poor glycemic control. It is an acute movement disorder characterized by sudden, non-purposeful jerking movements secondary to non-ketotic hyperglycemia. This is associated with high-intensity signals on T1-weighted magnetic resonance imaging of the brain noted at the basal ganglia. Case: We have a case of an 80-year old female who came in due to a four-day history of persistent involuntary, non-purposeful jerking of her right upper extremity accompanied by episodes of agitation and visual hallucinations. She has Diabetes Mellitus Type 2 for the past 20 years on Glibenclamide and Metformin. However, self-monitoring of blood glucose revealed fasting glucose levels as high as 300mg/dl. She was asymptomatic hence did not have regular follow-up with her primary care physician. She had no history of previous cerebrovascular disease. Family history was unremarkable. Upon examination, she was disoriented to place but answers appropriately to questions and did not have any speech abnormalities. On inspection it was noted that she had high amplitude involuntary flailing of the right upper extremity accompanied by non-purposeful jerking of her right lower extremity. Initial blood glucose level was 354mg/dl with an Hba1c of 13.7%. Serum ketones was within normal limits with a value of 0.1mmol/L. A plain Magnetic Resonance Imaging of the brain was done which showed a region of T1 weighted hyperintensity with no corresponding abnormal restricted diffusion nor increased susceptibility signals involving the left lentiform nucleus with no evidence of acute infarction nor intracranial hemorrhage noted. At this time, patient was co-managed by Endocrinology and Neurology service with an impression of a Diabetic Striatopathy. For the hemiballism and other neurologic manifestations such as agitation, visual hallucinations and disorientation patient was given risperidone and clonazepam. Blood glucose was then managed through cautious insulin therapy as well as hydration. On the third hospital day, there was noted resolution of right-sided hemiballismus and at this time glycemic control was improved. Conclusion: Proper identification and diagnosis is essential in managing Diabetic striatopathy. Although this may be a rare presentation of uncontrolled diabetes mellitus, clinicians should be aware of the possibility of an acute movement disorder as an unveiling symptom. This shows the importance of prompt blood glucose measurement in these acute cases. Once identified, adequate glycemic control through insulin therapy remains to be the center and most effective therapeutic management for the resolution of these hyperkinetic symptoms.

Presentation: Friday, June 16, 2023
SAT046 Canagliflozin Leads To Less Weight Gain, Confers Changes In The Gut Microbiota And Extends Life Span In Male C57BL6 Mice
Authors: Habeos Evagelia E , Filippopoulou Fotini , Kanakis Menelaos , Habeos George I , Belmokhtar Naima , Stathopoulou Panagiota , Tsiamis George , Taraviras Stavros , Lagoumintzis George , Chartoumpekis Dionysios V
Published: October 2023

Disclosure: E.E. Habeos: None. F. Filippopoulou: None. M. Kanakis: None. G.I. Habeos: None. N. Belmokhtar: None. P. Stathopoulou: None. G. Tsiamis: None. S. Taraviras: None. G. Lagoumintzis: None. D.V. Chartoumpekis: None.

Introduction: SGLT2 inhibitors (SGLT2i) are widely prescribed drugs for the treatment of diabetes. Their beneficial health effects appear to be pleiotropic and are not limited to the amelioration of glycemic profile. The SGLT2i-induced glycosuria is suggested to provoke a metabolic shift that mimics the fasting response. Since calorie restriction has been shown to enhance longevity in mice, we hypothesized that treating mice with SGLT2i would also increase their life span. Methods: To this end, 4-months old male C57BL6 mice were fed with a standard chow diet (Control, n=83) or a diet supplemented with 200 mg/kg canagliflozin (Cana, n=92) and were observed up to the natural end of their life. Results: The canagliflozin-treated mice gained less weight over time. For instance, at the age of 10 months, the body weight of control mice was higher (means ± SEM: 33.1 ± 0.26 g) than the body weight of their canagliflozin-treated counterparts (means ± SEM: 31.4± 0.21 g; p<0.01). The development and severity of age-related cataracts were also examined at the age of 14 months, but no statistically significant difference was found in the severity score between the 2 groups. The survival curves of the control and the Cana mice diverged significantly, with the median survival of the control being 107.5 weeks versus 112.5 weeks of the Cana group (p=0.011). As the gut microbiome is known to change with age and be associated with the development of age-related diseases, feces were collected from 17-month-old mice (n=10 per group) and analysis of fecal bacterial 16S rRNA sequences was performed. Differences in beta diversity (diversity of bacterial species across samples) and relative abundance of bacterial species were noted between the Control and the Cana groups. Conclusions-Discussion: Our study highlights the effect of SGLT2i on longevity in a widely used mouse model (C57BL6). The underlying mechanisms leading to the enhancement of longevity are not clear yet. Some microbiota changes associated with the SGLT2i treatment, as described in other mouse models with enhanced longevity, warrant further investigation and analysis. It would be useful to extend these studies employing various SGLT2i with different potencies and selectivity against SGLT so as to determine if the observed effect on longevity is independent of the type of the drug.

Presentation: Saturday, June 17, 2023
SAT102 Natural History Of Type 1 Diabetes In Humanized Mouse Model
Authors: Aldasouqi Ahmad , Rafiqi Shafiya Imtiaz , Jaume Juan Carlos , Imam Shahnawaz
Published: October 2023

Disclosure: A. Aldasouqi: None. S. Rafiqi: None. J.C. Jaume: None. S. Imam: None.

Type 1 diabetes (T1D) is an autoimmune disease caused by an imbalance in T-regulatory and T-effector cells characterized by the destruction of insulin-producing beta cells by T-effector cells, leading to insulin deficiency and complexities like diabetic nephropathy, retinopathy, and neuropathy. Researchers at The University of Toledo have developed a humanized mice model which spontaneously develops T1D at 3-5 weeks of age and mimics human T1D. This study aims to monitor blood glucose levels before the onset of T1D (preweaning stage mice) and track the dynamics of immune cells using flow cytometry throughout the progression of the disease. Our results show that T-regulatory cells constitute 4.773% ± 0.81% cells at preweaning which drops to 2.60± 0.35 (%) in males and 1.78 ± 0.58 (%) in females at the 10th week while CD8+ T cells producing interferon-gamma (cytotoxic lymphocytes, CTLs) constitute 3.32 ± 0.60 (%) at preweaning, which increased to 27.625± 1.43 (%) in males and 21.13± 2.87 (%) in females as the disease progresses. This reduction in T-regulatory cells and enrichment of CD8s and CTLs leads to the destruction of beta cells as seen in humans as well. Dysregulation of immune responses can be correlated with the progression of diabetes in terms of blood glucose levels which increased from 147mg/dl (preweaning), peaked to 373mg/dl in 5th week, and was observed in partial remission stage around the 8th week as observed in human T1D ‘honeymoon period’. This study will help us to understand the immune dynamics in the progression of T1D as it helps us to present a better picture of the status of immune cells in a human-like immune system and provides benchmark data of the interplay of the immune system.

Presentation: Saturday, June 17, 2023
SAT105 Frequent Monitoring Of Blood Glucose Levels Via A Remote Patient Monitoring System Helps Improve Glycemic Control
Authors: Sachmechi Issac , Amini Masoud , Salam Sanna , Khan Rubba , Spitznogle Andrew , Belen Tasheena
Published: October 2023

Disclosure: I. Sachmechi: None. M. Amini: None. S. Salam: None. R. Khan: None. A. Spitznogle: None. T. Belen: None.

Objective: This study aims to evaluate the effectiveness of the Vivovitals telehealth platform on improving glycemic control and reducing A1C in patients with uncontrolled type II diabetes mellitus by providing more accessible and frequent patient care under the monitoring by their physician. Methods: This 12-week, prospective, pragmatic, single-center, double-arm study assessed the impact of the Vivovitals diabetes platform on glycemic control among 78 adults ≥ 18 years of age, with A1C ≥ 7.5% (58 mmol/mol) at baseline. The participants were randomized into two groups. The control group received standard care, while the intervention group was assisted to install the application on their smartphones and connect it to a Bluetooth Glucometer, and access to an online data portal. Blood glucose measurements were transmitted to the provider daily. Patients were contacted twice weekly regardless of their blood sugar measurements and additional call was made if blood glucose levels were <70 mg/dL or >180 mg/dL and modifications were made to diet and medication. The control group was allowed to call the provider if they have questions regarding their blood sugar levels or their medications. The two groups were compared at baseline and 12 weeks using nonparametric tests with p<0.05 considered statistically significant. Results: The mean A1C in the intervention group (n=39) was 9.53 (81 mmol/mol) +1.68 at baseline. Post-trial, mean A1C decreased to 7.99 (64 mmol/mol) + 1.40 (p < 0.001). In comparison, the mean A1C in the control group (n=39) was 9.63 (64 mmol/mol) + 1.47 at baseline with little change in post-trial mean A1C averaging 9.16 (77 mmol/mol) + 1.51 (p = 0.87). Discussion: In this study, patients who utilized the Vivovitals platform saw a significant decrease in A1C at an average of 1.56% compared to the non-significant 0.47% A1C reduction in the control group participants. We believe the A1C-reducing effect in the intervention group was due to the more frequent interactions with the physician and subsequent medication adjustments based on the data provided. The Vivovitals platform allows an affordable closer monitoring of blood glucose levels, identification of the direction of glycemic trends, and earlier intervention. While not explored in this study, it is reasonable to believe that the use of the Vivovitals diabetes platform could reduce Emergency Department visits and inpatient hospitalizations for hypoglycemia or hyperglycemia as the clinician can intervene before a patient becomes symptomatic. Conclusion: We conclude that the Vivovitals platform may help to reduce A1C in adults with uncontrolled type 2 diabetes mellitus in conjunction with lifestyle modifications and anti-diabetic medications.

Presentation: Saturday, June 17, 2023
Radiosurgery With Prior Embolization Versus Radiosurgery Alone for Intracranial Arteriovenous Malformations: A Systematic Review and Meta-Analysis
Authors: Maroufi Seyed Farzad , Fallahi Mohammad Sadegh , Khorasanizadeh MirHojjat , Waqas Muhammad , Sheehan Jason P.
Published: October 2023

BACKGROUND AND OBJECTIVES:

The addition of adjuvant embolization to radiosurgery has been proposed as a means of improving treatment outcomes of intracranial arteriovenous malformations (AVMs). However, the relative efficacy and safety of radiosurgery with adjuvant embolization vs radiosurgery alone remain uncertain. Moreover, previous systematic reviews and meta-analyses have included a limited number of studies and did not consider the effects of baseline characteristics, including AVM volume, on the outcomes. This systematic review aimed to evaluate the efficacy of preradiosurgery embolization for intracranial AVMs with consideration to matching status between participants in each treatment group.

METHODS:

A systematic review and meta-analysis were conducted by searching electronic databases, including PubMed, Scopus, and Cochrane Library, up to January 2023. All studies evaluating the utilization of preradiosurgery embolization were included.

RESULTS:

A total of 70 studies (9 matched and 71 unmatched) with a total of 12 088 patients were included. The mean age of the included patients was 32.41 years, and 48.91% of the patients were female. Preradiosurgery embolization was used for larger AVMs and patients with previous hemorrhage (P < .01, P = .02, respectively). The obliteration rate for preradiosurgery embolization (49.44%) was lower compared with radiosurgery alone (61.42%, odds ratio = 0.56, P < .01), regardless of the matching status of the analyzed studies. Although prior embolization was associated higher rate of cyst formation (P = .04), it lowered the odds of radiation-induced changes (P = .04). The risks of minor and major neurological deficits, postradiosurgery hemorrhage, and mortality were comparable between groups.

CONCLUSION:

This study provides evidence that although preradiosurgery embolization is a suitable option to reduce the AVM size for future radiosurgical interventions, it may not be useful for same-sized AVMs eligible for radiosurgery. Utilization of preradiosurgery embolization in suitable lesions for radiosurgery may result in the added cost and burden of an endovascular procedure.
Physical Activity Associates with T1rho MRI of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction
Authors: Davis-Wilson Hope C. , Thoma Louise M. , Franz Jason R. , Blackburn J. Troy , Longobardi Lara , Schwartz Todd A. , Hackney Anthony C. , Pietrosimone Brian
Published: October 2023

Purpose

Less physical activity has been associated with systemic biomarkers of cartilage breakdown following anterior cruciate ligament reconstruction (ACLR). Yet, previous research lacks analysis of deleterious cartilage compositional changes and objective physical activity following ACLR. The purpose of this study was to determine the association between physical activity quantified via accelerometer-based measures of daily steps and time in moderate-to-vigorous physical activity (MVPA), and T1rho magnetic resonance imaging (MRI) of the femoral articular cartilage, a marker of proteoglycan density in individuals with ACLR.

Methods

Daily steps and MVPA were assessed over 7 days using an accelerometer worn on the hip in 26 individuals between 6-12 months following primary unilateral ACLR. Resting T1rho MRI were collected bilaterally, and T1rho MRI inter-limb ratios (ILR: ACLR limb/contralateral limb) were calculated for lateral and medial femoral condyle regions of interest. We conducted univariate linear regression analyses to determine associations between T1rho MRI ILRs and daily steps and MVPA with and without controlling for sex.

Results

Greater T1rho MRI ILR of the central lateral femoral condyle, indicative of less proteoglycan density in the ACLR limb, was associated with greater time in MVPA (R2 = 0.178, P = 0.032). Sex-adjusted models showed significant interaction terms between daily steps and sex in the anterior (P = 0.025), central (P = 0.002), and posterior (P = 0.002) medial femoral condyle.

Conclusions

Lesser physical activity may be a risk factor for maintaining cartilage health following ACLR; additionally, the relationship between physical activity and cartilage health may be different between males and females.
Μέτρηση της διαφορικής ενεργού διατομής του ζεύγους Top Anti-Top quark με τον ανιχνευτή CMS στο LHC
Authors: Παπακριβόπουλος Ιωάννης
Published: October 2023

Η παρούσα διατριβή είναι αποτέλεσμα της δουλειάς που έγινε για την μέτρηση της διαφορικής ενεργού διατομή του ζεύγους τοπ/αντί-τοπ κουάρκ μεγάλης εγκάρσιας ορμής τα οποία διασπούνται αδρονικά. Για την πραγματοποίηση της χρησιμοποιήθηκαν δεδομένα τα οποία συλλέχθηκαν από τον ανιχνευτή CMS κατά τη διάρκεια του"Run-II" του LHC. Τα δεδομένα αυτά αντιστοιχόυν σε ϕωτεινότητα 137.1f b−1 και για να παραχθούν έγιναν συγκρούσεις με ενέργεια κέντρου μάζας 13 TeV. Η παρούσα μέτρηση είναι μια μέτρηση ακρίβειας. Στο παρελθόν τα έχει ξαναπραγματοποιησεί τόσο από το πείραμα CMS όσο και απλό το πείραμα ATLAS. Στην παρόυσα εργασία έγινε προσπάθεια μέτρησης με μεγαλύτερη ακρίβεια τροποποπιώντας τη μέθοδο που είχε χρησιμοποιήσει παλαιότερα το πείραμα CMS αλλά και χρησιμοποιώντας κάποια διαφορετικά εργαλέια σε συγκεκριμένα σημεία. ΄Ενα ακόμα στοιχείο το οποίο ϐοηθάει στην επίτευξη μεγαλύτερης ακρίβειας είναι οτι χρησιμοποιήθηκαν σχεδόν τετραπλάσια δεδομένα σε σχέση με την προηγούμεη μέτρηση του CMS. Μία ακόμα προσθήκη στη μελέτη αυτή είναι στο κομμάτι της σύγκρισης με τη ϑεωρία. Οι προηγούμενες μετρήσεις και από τα δύο ξεχωριστά πειράματα είχαν παρατηρήσει μια ασυμϕωνία μεταξύ των δεδομένων και των ϑεωρητικών προβλέψεων. Στη παρούσα ανάλυση γίνεται μια προσπάθεια ποσοτικοποίησης αυτής της ασυμφωνίας. Αυτό γίνεται σε πρώτο στάδιο με την χρήση συστηματικών σφαλμάτων στα διάφορα ϑεωρητικά μοντέλα. Στη συνέχεια για τον σκοπό αυτό, υπολογίζονται οι τιμές του χ2 αλλά και ταp-values. Κατα τη διάρκεια της διατριβής αυτής, έγινε και εκτεταμένη δουλειά στο σύστημα αυτομάτου ελέγχου του ανιχνευτή CMS. Η δουλειά αυτή, έγινε σαν service work στο CMS collaboration. Η δουλειά αυτή περιστράφηκε κυρίως γύρω από την συντήρηση και ϐελτίωση του συστήματος αυτού με σκοπό την καλύτερη λειτουργία του ανιχνευτή κατά τη διάρκεια του "Run-II". Η δουλεία αυτή δεν επηρέασε μόνο την παρούσα διατριβή αλλά ολόκληρο το πείραμα καθώς επέτρεψε την ομαλότερη λειτουργία του ανιχνευτή. Σαν αποτέλεσμα ο ανιχνευτής λειτούργησε με τις ϐέλτιστες δυνατές συνθήκες επιτρέποντας έτσι τη συλλογή υψηλής δεδομένων ποιότητας.
Προσφυγικά υποκείμενα και ευάλωτοι πολίτες στη σύγχρονη φεμινιστική θεωρία
Authors: Πολυχρονίου Αριάδνη
Published: October 2023

Η παρούσα διατριβή διερευνά το σχεσιακό θεμέλιο της ηθικοπολιτικής συνδεσιμότητας προσφυγικών υποκειμένων και ευάλωτων Δυτικών πολιτών μέσα από τη μεταδομιστική φιλοσοφία της Judith Butler και την κοινωνική θεωρία της Iris Young. Ειδικότερα, η σύγχρονη ανάδυση πλουραλιστικών μορφών φιλοπροσφυγικής αλληλεγγύης επαναπροσεγγίζεται δια της κριτικής ανασύνθεσης της μπατλερικής ευαλωτότητας και της γιανγκιανής πολιτικής ευθύνης. Στην πρώτη ενότητα επικεντρωνόμαστε στην ερωτητική της συγκρότησης του υποκειμένου στη θεωρητική παραγωγή των δύο στοχαστριών. Στη δεύτερη ενότητα προβαίνουμε στη θεωρητική ανασύσταση της μπατλερικής εννόησης της ευαλωτότητας και στην κριτική συστηματοποίηση της γιανγκιανής κατασκευής του Μοντέλου της Κοινωνικής Διασύνδεσης της ευθύνης. Στην τρίτη ενότητα επιχειρούμε πρωτογενώς να εφαρμόσουμε την μπατλερική ηθικοπολιτική της ευαλωτότητας και τη γιανγκιανή θεωρητική κατασκευή σε μείζονες ερωτητικές του τρέχοντος προσφυγικού φαινομένου. Η λογοθετική συγκρότηση του προσφυγικού υποκειμένου, η επιτελεστική προσφυγική αγωνιστικότητα, ο συστημικός χαρακτήρας των κοινωνικο-δομικών αδικιών που επωάζονται στο εσωτερικό του σύγχρονου βιοπολιτικού καθεστώτος των συνόρων και η υφή των ηθικοπολιτικών υποχρεώσεων των Δυτικών κοινωνικών δρώντων απέναντι στα προσφυγικά υποκείμενα αναδεικνύονται σε κεντρικούς άξονες προβληματισμού. Καταληκτικά, αποπειρόμαστε να ιχνηλατήσουμε μια κριτική φεμινιστική διαλεκτική ευαλωτότητας και ευθύνης, σκιαγραφώντας μια μεικτή θεωρία αταυτοτικής αλληλεγγύης μέσα από την παραγωγική ώσμωση του ύστερου μπατλερικού ηθικοπολιτικού στοχασμού με την κριτική κοινωνική θεωρία της Young.
Nursing Education for Pediatric Cardiac Care Centers in Developing Countries
Authors: Peterson Jennifer
Published: October 2023

Summary

Pediatric cardiac programs achieve excellent patient outcomes through the teamwork of a highly capable interdisciplinary team. Nurses are key members of this team, and must possess and highly specialized set of skills and knowledge. A comprehensive nursing education program is needed to develop the necessary skills and knowledge to care for critically ill infants and children with heart disease who are often highly unstable, complex, and vulnerable. Orientation of novice nurses or those who are new to the unit begins with a needs assessment, resulting in a comprehensive plan to achieve required competencies. Nurse residency programs are one method to provide a comprehensive orientation to novice nurses, using a combination of didactic instruction, preceptored clinical experiences, and simulation. An ongoing nursing education plan is also important to refresh skills, especially with high-risk, low-volume procedures, as well as to meet regulatory requirements and develop new skills and knowledge. A key component of the pediatric cardiac nursing education plan is development of preceptors, who provide hands-on instruction to mentor new nurses to develop the needed skills and knowledge, while ensuring that patients receive safe care. Preceptor development can also provide experienced bedside nurses with opportunities to develop their own knowledge and to continue professional development, which helps to positively influence job satisfaction. Numerous resources are available to develop a curriculum or the pediatric cardiac program. Evaluation is also an important component of the nursing education program, to quantify individual as well as programmatic outcomes.
The South American paradigm of Congenital Heart Disease care
Authors: Lugones Ignacio , Biancolini María Fernanda
Published: October 2023

South America is a land of contrasts. These contrasts encompass both nature and human activity. The health of individuals takes place within this context. In particular, congenital heart diseases, due to the complexity of their diagnosis and treatment, present a significant challenge for the region. Despite a large portion of the population lacking access to these services, the region is a pioneer in innovation in this field. Great surgeons from there have left an indelible legacy that still impacts the lives of people around the world today.
Methodological support of the educational process: digital control and evaluation tools for conducting current control and intermediate certification in the discipline "Tourism and sports orienteering" for students of the training direction 44.03.01 Pedagogical education, orientation (profile) Physical Culture
Authors: Goncharova Oksana V.
Published: October 2023

Digital control and evaluation tools for conducting current control and intermediate certification in the discipline "Tourism and sports orienteering" are intended for students of the training direction 44.03.01 Pedagogical education, orientation (profile) Physical Culture. The goal is to control the generated systematized knowledge in the field of teaching methods for the basics of sports tourism and orienteering.
El Galba de Historias, ¿una etopeya de Nerva?/Galba in Histories, an ethopoeia of Nerva?
Authors: Castillo Pascual Pepa
Published: October 2023

El objetivo de esta contribución es demostrar que el Galba que Tácito nos presenta en Historias es una crítica velada a Nerva, sobre todo en lo referente a su avanzada edad. La forma en como ambos alcanzaron el poder, su prestigioso origen, su avanzada edad y la falta de descendencia eran elementos suficientes para que los lectores de Tácito viesen en Galba un trasunto de Nerva. Por otra parte, el discurso que Tácito pone en boca de Galba en ocasión de la adopción de Pisón muestra mucho más esta vinculación entre Galba y Nerva. Es evidente que se trata de una proyección de otro proceso de adopción más cercano para él y sus lectores, el de Trajano por Nerva.
Tácito y los hombres de mérito bajo el reinado de Tiberio/Tacitus and the men of merit under the reign of Tiberius
Authors: Balmaceda Errázuriz Catalina
Published: October 2023

Este trabajo busca analizar los personajes que Tácito destaca como dignos de mérito durante el nuevo sistema político del Principado y que reciben una alabanza o elogio por parte del historiador en la primera héxada de sus Anales. Se examinan también los factores que se constituyen como meritorios bajo el reinado de Tiberio y que reciben algún tipo de compensación política por parte del emperador.
¿Qué es la Escuela de Salamanca? Nuevas perspectivas/What is the School of Salamanca? New perspectives
Authors: Belda Plans Juan
Published: October 2023

Se analiza el debate actual sobre el concepto de Escuela de Salamanca. Se muestran las nuevas propuestas de los estudiosos: su carácter global (no solo Salamanca); su alcance interdisciplinar (no solo teológico, también jurídico, económico, sociopolítico, etc); la cuestión de los miembros también experimenta una ampliación, aunque siempre se señala un cierto cordón umbilical con los Maestros salmantinos; todo ello dentro de un marco temporal que se extiende durante el siglo XVI y primera mitad del XVII. Estas nuevas perspectivas no excluyen los elementos tradicionales, sino que amplían y desarrollan el concepto primitivo, pero con carácter inclusivo. Por último, se aborda el tema de las condiciones de posibilidad de la Escuela, que se con-textualiza en un ámbito histórico que la hace posible. Al término del estudio se ofrece un posible nuevo concepto de la Escuela, todavía in fieri.
Metodologia de utilização do Microscale Audit of Pedestrian Streetscapes-MAPS na cidade de São Paulo
Authors: Oliveira Elaynne Silva de , Paula Ítalo Vinícius Floriano de , Silva Alexandre Augusto de Paula , Hino Adriano Akira Ferreira , Teixeira Inaian Pignatti , Prado Raul Cosme Ramos , Lacerda Jader Correia de , Oliveira Larissa Felix de , Florindo Alex Antonio
Published: October 2023

O Microscale Audit of Pedestrian Streetscapes-Global (MAPS-Global) é um instrumento internacional que visa caracterizar a variabilidade de ambientes de pedestres relacionados à atividade física ao nível de microescala, sendo uma ferramenta confiável que permite comparações entre locais com diferentes contextos. Neste sentido, o objetivo do presente estudo é descrever o processo metodológico adotado na pesquisa Inquérito de Saúde de São Paulo (ISA) - Atividade Física e Ambiente para a avaliação da microescala do ambiente com o instrumento MAPS-Global. A utilização do método na cidade de São Paulo envolveu diversas etapas e adaptações relevantes para o contexto do estudo, inicialmente foram realizadas reuniões com o grupo responsável por validar o método no Brasil, treinamento dos pesquisadores para coletas de dados, revisão dos blocos e questões, hospedagem do instrumento no Google forms, georreferenciamento dos domicílios, elaboração das rotas, treinamento e certificação dos avaliadores e procedimentos de coletas de dados. A auditagem do ambiente apresentou desafios, mesmo se tratando de um processo exclusivamente online, foram necessários 25 meses para o desenvolvimento de todas as etapas do estudo, pois a avaliação envolveu 1.434 sujeitos, aumento da cobertura da avaliação nas seções dos segmentos e cruzamentos e uma equipe de sete avaliadores. Sugere-se para coletas futuras que seja observado o tempo disponível para auditagem, o tamanho da equipe para a amostra selecionada, bem como a possibilidade realizar adaptações no instrumento como a inclusão ou retirada de itens conforme contexto ou realidade local do estudo.
Optimal and Differentially Private Data Acquisition: Central and Local Mechanisms
Authors: Fallah Alireza , Makhdoumi Ali , Malekian Azarakhsh , Ozdaglar Asuman
Published: October 2023

The data for many machine learning tasks are owned by individuals who are typically concerned about privacy. Here, the authors study the optimal design of a data acquisition mechanism aimed at learning the mean of a population. This data acquisition scheme includes the design of a payment rule to compensate users for their privacy loss. It also involves selecting an estimator that minimizes estimation error while simultaneously providing privacy guarantees to users in line with their privacy preferences. The authors formulate this problem as a Bayesian mechanism design problem and propose approximately optimal data acquisition mechanisms.
Effect of oil and tannin supplementation on intake, milk yield and milk composition of dairy cows
Authors:   Department of Animal Sciences, College of Agriculture, Can Tho University, Ninh Kieu, Can Tho 94000, Viet Nam, Thanh Lam Phuoc , Kha Pham Truong Thoai ,   Department of Animal Sciences, College of Agriculture, Can Tho University, Ninh Kieu, Can Tho 94000, Viet Nam, Ha Nguyen Thi Thu ,   Department of Animal Sciences, College of Agriculture, Can Tho University, Ninh Kieu, Can Tho 94000, Viet Nam, Mai Duong Tran Tuyet ,   Department of Animal Sciences, College of Agriculture, Can Tho University, Ninh Kieu, Can Tho 94000, Viet Nam, Tu Mai Hoan ,   Department of Animal Sciences, College of Agriculture, Can Tho University, Ninh Kieu, Can Tho 94000, Viet Nam, Hang Tran Thi Thuy ,   Department of Agricultural Technology, College of Rural Development, Can Tho University, Phung Hiep, Hau Giang 95000, Viet Nam
Published: October 2023

Supplementation of oils rich in polyunsaturated fatty acids and condensed tannin has been known as a feeding approach to improve healthy fatty acids in ruminant milk, but it can cause an adverse effect on feed intake and animal performance. This study aimed to investigate the effect of feeding oil alone or in combination with grape seed tannin extract (GSTE) on feed intake, milk yield and composition of dairy cows. Sixteen low production dairy cows in mid-lactation fed a basal diet based on agro-industrial by-products were arranged to a completely randomized design for a 6-week duration. Animals were fed basal diet without oil and GSTE inclusion (CON), 2.5% DM soybean oil (SBO), 2.5% DM blend of soybean oil and tuna fish oil at 3:2 w:w (SFO), or SFO plus 0.4% DM GSTE (OCT). The results showed that DM intake was reduced (P < 0.05) by 14.4% in OCT relative to CON. Milk yield was not affected by oil and GSTE supplementation, but SFO and OCT strongly depressed milk fat, protein and total solids (P < 0.001). In conclusion, in a low production cow diet based on agro-industrial by-products containing high lipid, supplementation of oil and GSTE should be considered in the aspects of feed intake and milk composition.
Cultural Networks of the Chungin : Chosŏn Interpreters' Participation in Poetry Societies
Authors: Hu Jing
Published: October 2023

Abstract: This paper illuminates the cultural performance of Chosŏn (1392–1910) interpreters in the nineteenth century, with a particular focus on interpreters' participation in poetry societies ( sisa 詩社). The study aims to explore the cultural status of interpreters by examining the networks they built within poetry societies and to investigate whether engagement in cultural activities contributed to their social mobility in the late nineteenth century. Existing scholarship on the social mobility of the chungin (中人, "middle people") heavily relies on the influence of demographic expansion and position monopoly, at the expense of other indicators reflecting the chungin's social position such as economic, cultural, and political standing. To bridge this research gap, this research uses the cultural life of Chosŏn interpreters as a lens to examine how the chungin interacted with other groups. I use Kang Wi's (姜瑋 1820–1884) Kohwandang such'o (古歡堂收艸, "Collected Works of Kang Wi") as the primary source to extract social connections between the Poetry Society of the Sixth Bridge (Yukkyo sisa 六橋詩社), of which most members were official interpreters and medical doctors living in Hanyang, and the South Poetry Society, which was a poetry community organized by the yangban . Through analyzing clusters and patterns based on the concurrence of the participants, this study concludes that the cultural status of the chungin did not fully align with their categorization in the social hierarchy, and the social gap between the yangban and the chungin did not cease because of cultural exchanges.
Intrigues for Power: The Tokugawa Shogunate, the Japanese Court, and the Korean Embassy in the Seventeenth and Eighteenth Centuries
Authors: Lee Jeong-Mi
Published: October 2023

Abstract: This article discusses the perspectives of three parties: the Korean embassy officials dispatched from the Chosŏn court (1392–1910), the Tokugawa shogunate (1603–1868), and the imperial court in Kyoto. Immediately after establishing the military government in 1603, the Tokugawa shogunate attempted to consolidate its own military foundation and complete the unification of the country. During this process, inviting the Korean embassy to the Tokugawa shogunate was one of the most important events undertaken by the shogunate, demonstrating to other samurai families that the Tokugawa house was the strongest political authority in the country. Under the Tokugawa regime, the imperial court played a nominal role without political influence. Nonetheless, the shogunate may have considered the imperial court as a latent threat. The members of the imperial family were willing to engage with the Korean embassy for further cultural exchange. In the travelogues to Japan, the officials of the Korean embassy recorded their concerns on the relationship between the imperial court and the shogunate. Their analysis of the matter mentioned the ambiguity of the neighborly relations in the future if the emperor were to recapture political power and thus alarmed whether the new ruler would have maintained amicable relations with Chosŏn. This research focuses on how Korean embassy officials viewed the imperial court, and also the shogunate's reaction to communication between the embassy officials and members of the imperial family who were interested in both the embassy officials and Korean culture.
Riding the Wave to Ni-Chōme: Tokyo's Korean Gay Bars in the 2000s
Authors: Graves Albert
Published: October 2023

Abstract: This article introduces Korean gay space, place, and identity in Japan, as revealed in Tokyo's Korean gay bars that emerged at the start of Japan's Korean Wave in the 2000s. It focuses on the intersections of race and sexuality in interactions among the actors that produce and consume these establishments, exposing racialized spaces of desire besides those limited to white Westernness. It presents an overview of Korean gay identity against the backdrop of Koreaphobia in Japan and homophobia among zainichi , along with an examination of the Korean Wave, its impact on the queer diaspora, and the gay commodification of Koreanness. The study comparatively analyzes racial groupings in the bar, seeking clarity on the representations of self and other among gay Koreans and with gay Japanese. A series of conclusions are made: (1) Korean gay men's experience in Japan is shaped by having to contend with separate closets for race and sexuality, compounded by racism and homophobia from within their own communities dissociated from "Japan." (2) The Korean Wave has created a new category of desire among gay men through a middle ground or third space around a borderless, hybridized community of communities. (3) Korean gay bars simultaneously function as consumer spaces for what the author terms "proximate opposites" with Japanese, and as community centers for racially one yet ideologically divided Koreans. The study sets out to recover and preserve a history that would otherwise have been lost from memory with decades of scholarly inattention to its existence.
Meeting Users’ Information Needs Online during the Russian-Ukrainian War
Authors: Prokopenko Liudmyla , Skachenko Olena
Published: October 2023

abstract: This article explores users’ level of satisfaction with the information in the online space of a university library during the pandemic and the russian-Ukrainian war. The authors analyzed the services and activities that the library provided online and examined whether they satisfied users’ information needs. Using a questionnaire, the study surveyed students and faculty members of the Kyiv National University of Culture and Arts in 2023. The study revealed that users rely on online library services for many different information needs. The authors do not rule out that their results were influenced by current conditions in Ukraine, such as intensive military operations lasting more than a year, forced relocation of students and teachers to less dangerous regions, concern for the safety of educational and informational activities during constant rocket attacks, power outages, and unstable Internet connection. This article will be useful to those interested in meeting library users’ information needs during a pandemic, war, or other instability. Respondents’ suggestions for service improvement, conclusions, and recommendations will help university libraries to organize their activities more effectively to maximize users’ satisfaction in the online space.
Place Attachment, Libraries, and Student Preferences
Authors: Diller Karen R. , Wallin Sam B.
Published: October 2023

abstract: This study examines student use of and reaction to study spaces in academic libraries through the lenses of place attachment, including appropriation, affordance, and attention restoration theories. Experimenting with new methods of research (four of six methods were new), researchers identified the walking interview as the best for examining their research questions. They found that students identify the library as a study space, and they rely on the library and those within it to reinforce the discipline of study. Findings include more detailed insight into the “study ethos,” noise or distraction levels, decor, and other aspects of study spaces.