bluuebunny/crossref_metadata_2025 huggingface dataset:
Breast cancer and paraneoplastic dermatomyositis: A literature review
Authors: Ribeiro Laíse Alves , Aranha Carlos Eduardo Nunes , Camargo João Victor Monteiro de , Santos Daiane Rose Dantas , Resende Geovana Sousa , Galli Alexandre Pelícolla
Published: January 2024

Objective: Breast cancer (BC) is the most common malignancy in women. Contrastingly, dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by symmetric proximal muscle weakness and skin lesions. Gottron’s papules and heliotrope are pathognomonic signs. This article aimed to describe how the diagnosis and treatment of patients with both diseases have been performed. Methodology: As this study consists of a literature review, submission to the Research Ethics Committee was not necessary. Articles indexed in the PubMed and SciELO electronic databases were collected. Cross-sectional and retrospective observational studies were selected using the following descriptors: (Breast Cancer) AND (Dermatomyositis). Finally, 19 studies were read in full and included in this systematic review. Results: An underlying neoplasm is present in 50% of DM patients older than 45 years. A newly diagnosed DM in the latter, should, therefore, be associated with an etiologic search of paraneoplastic origin. This may allow an early BC detection. This is corroborated by the significant stage 1 BC detected in patients with rheumatic diseases, according to a cohort analysis. Furthermore, cases in which DM indicated cancer recurrence have been reported. DM is associated with higher BC mortality, and the most correlated histotype is invasive ductal carcinoma. Currently, there are no guidelines or randomized trials for the management of BC complicated by DM. Therapeutic management of DM is mainly based on corticosteroids and immunosuppressive agents. However, previously published case reports indicated that surgical excision of the tumor is successful, as it can stop the progression of DM and prevent deterioration of muscle function. Conclusion: BC can feature uncommon presentations, such as paraneoplastic DM. Due to the absence of guidelines for the management of BC concomitant with DM, a multidisciplinary approach, including oncologists, dermatologists, and rheumatologists, is mandatory.
Scope of diagnostic and screening methods for breast cancer among women in the state of pernambuco: Knowing in order to intervene
Authors: Ferreira Filho Darley de Lima , Ferreira Nancy Cristina Ferraz de Lucena , Ferreira Thais de Lucena
Published: January 2024

Objective: The objective of this study was to know the diagnostic and screeming methods for breast cancer, made available by public health services and their reach among women in the state of Pernambuco. Methodology: This is a cross-sectional, descriptive, and retrospective study, whose data were obtained by consulting the Siscan database, made available by datasus. This study population consisted of female patients of all age groups in the state, from January to December 2021. The variables were grouped taking into account three indicators: mammography, cytology, and histology. Results: A total of 147,852 mammograms were performed, with the 50–54-year-old group being the most prevalent. Of the total, 145,745 were for screening purposes and 2,136 for diagnostic purposes of the mammographic reports obtained results with BI-RADS 4 and 5. There was a predominance BI-RADS 1. The number of cytology performed was only 404, with the most prevalent age group between 45 and 49 years, with 180 tumors of solid type, where 12.6% were positive, suspected, or indeterminate for malignancy. According to the histopathological report, the rate of malignant breast lesions was approximately 47.92%, with prevalence in the age group between 45 and 49 years. Only 1,810 of the lesions could be diagnosed by imaging and 879 were palpable on clinical breast examination. Conclusion: This study demonstrated the need to expand the age group recommend by the ministry of health for breast cancer screeming, for an earlier onset, from the age of 40 years. In addition, the scope of diagnostic methods is still frustrating, as a small number of women progress in the investigation.
Survival analysis of patients with 10 or more axillary lymph nodes compromised by breast cancer
Authors: Carvalho Débora Medeiros de , Bacelar Josielly Ferreira , Estevão Joarla Ayres de Morais , Barros Emanuelle de Lima , Leão Mariana de Souza Arêa , Paranaguá Josie Haydée Lima Ferreira , Lima Carlos Eduardo Moura de , Vieira Sabas Carlos
Published: January 2024

Objective: The objective of this study was to evaluate survival in patients with 10 or more compromised axillary lymph nodes. Methodology: This is a retrospective cohort study conducted in a private oncology clinic in Teresina, Piauí, Brazil, in the period 1999–2023, where medical records of 12 patients with breast cancer who had 10 or more compromised axillary lymph nodes were analyzed. The following variables were observed: patient age, histological type of tumor, tumor size, lymphatic invasion, vascular invasion, perineural invasion, number of lymph nodes dissected, number of axillary lymph nodes compromised, treatment with radiotherapy and/or chemotherapy, occurrence of recurrence and/or metastasis, and patient survival. Survival functions were calculated using the Kaplan-Meier method. This study was approved by the Research Ethics Committee of the Universidade Estadual do Piauí (CEP-UESPI), Teresina, Piauí, Brazil, opinion number 4.311.835. Results: The mean age of the patients was 58.66 years. The mean tumor size was 4.6 cm. There was a predominance of invasive carcinoma of the non-special histological type (10–83.33%), followed by invasive lobular carcinoma (1–8.33%) and invasive tubular carcinoma (1–8.33%). As for lymphovascular invasion, 6 (50%) patients had vascular invasion, 7 (58.33%) had lymphatic invasion, and 3 (25%) had perineural invasion. The mean number of LAX compromised was 13.17, while the mean number of lymph nodes dissected was 20.25. Of the 12 patients, 9 were treated with radiotherapy (75%) and 10 were treated with chemotherapy (83.33%). Of the total, 6 (50%) patients had some form of recurrence, of whom 4 progressed to death. Distant metastasis occurred in 4 (30%) patients. Conclusion: The survival rate in a time interval of 5 years for patients with 10 or more compromised axillary lymph nodes was 51.6%.
Prepectoral breast reconstruction. Report after 4 years of follow-up: Experience of a Chilean tertiary general hospital
Authors: Letzkus Jaime , Belmar Florencia , Lagos Jose M. , Río Maria José del , G. Jorge Gamboa , Gonzalez Rodrigo , Belmar Guillermo A. , Hidalgo Daniela B.
Published: January 2024

Objective: Implant-based breast reconstruction (IBBR) has become the leading method for immediate breast reconstruction worldwide, for several years using the sub-pectoral plane. Post-mastectomy radiotherapy (PMRDT) and breast reconstruction are associated with complications including implant loss and animated breast deformity. The animated breast deformity can be avoided using the pre-pectoral plane IBBR. The objective of this report is to show 4 years of experience and results on pre-pectoral IBBR (PPIBBR) at a University Clinical Hospital. Methodology: The data were collected prospectively from a personal database. Selection criteria were based upon oncological considerations, multidisciplinary committee evaluation, and indication of mastectomy. The distance of tumors from the skin and proper subcutaneous fat thickness were evaluated. A review of general comorbidities, body mass index, smoking, breast weight, pathology report, and complications of any kind, including implant loss and its association with radiotherapy, was included. Results: The cohort study included 77 patients (81 PPIBBR procedures), from July 2019 to March 2023. The mean age was 47 (27–70) years. Eight (9.7%) patients were mutation carriers (4 BRCA1, 2 BRCA2, and 2 TP53). Out of 10 patients, 6 with bilateral breast reconstruction had a PPIBBR. Most of the procedures were done following the same technique and by the same senior surgeons’ team. Mesh was used in 38% (31/81), mostly absorbable synthetic mesh. Most complications were considered mild (14.8%, n=12/81) or moderate (19.7%, n=16/81) and were managed as outpatient treatment. We have only 3 (3.7%) breast implant losses among 81 procedures and only one was related to PMRDT prior to actual reconstruction. Conclusion: PPIBBR is so far a safe and feasible breast reconstructive technique, with a very low complication rate in well-selected patients. It can be used for therapeutic or risk reduction purposes, and the aesthetic results are mostly good and excellent according to the Harris Scale evaluation and avoid the disadvantage of subpectoral implant placement.
Implementasi Kegiatan Ekstrakurikuler Cilokaq dalam Membangun Karakter Cinta Tanah Air (Studi di SMAN 1 Praya Timur)
Authors: Maharani Maharani , Yuliatin Yuliatin , Algadri Bagdawansyah , Zubair Muh.
Published: January 2024

Pendidikan karakter khususnya karakter cinta tanah air terutama di sekolah menjadi sangat penting keberadaannya di tengah perkembangan arus globalisasi. Penelitian ini bertujuan untuk mendeskripsikan implementasi kegiatan ekstrakurikuler cilokaq dalam membangun karakter cinta tanah air di SMAN 1 Praya Timur dan faktor yang mempengaruhinya. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian deskripstif. Adapun teknik pengumpulan data yang digunakan adalah teknik wawancara, observasi, dan dokumentasi. Teknik analisis data yang digunakan adalah model Miles and Huberman dengan langkah-langkah yang meliputi mengumpulkan data, reduksi data, penyajian data, dan penarikan kesimpulan. Uji keabsahan data yang digunakan dalam penelitian ini merujuk pada teori Sugiyono yaitu triagulasi sumber, triagulasi teknik, dan triangulasi waktu. Hasil penelitian ini menunjukan bahwa implemetansi kegiatan ekstrakurikuler cilokaq dalam membangun karakter cinta tanah air di SMAN 1 Praya Timur terdapat beberapa aspek yang berorientasi pada karakter cinta tanah air yaitu, kegiatan menyanyikan lagu daerah, menggunakan busana daerah, dan memainkan musik tradisional. Adapun faktor yang mempengaruhi implemetasi kegiatan ekstrakurikuler cilokaq dalam membangun karakter cinta tanah air di SMAN 1 Praya Timur meliputi faktor pendukung dan faktor prnghambat. Faktor pendukung meliputi: (1) kompetensi pelatih, (2) dukungan pendidik, (3) ketersediaan tempat pelaksanaan ekstrakurikuler cilokaq, (4) ketersediaan fasilitas alat kesenian. (5) partisipasi peserta didik dalam pelaksanaan ekstrakurikuler cilokaq,dan (6) dukungan orang tua. Sementara faktor penghambat yaitu (1) tidak ada panduan kegiatan ekstrakurikuler cilokaq yang dibuat secara khusus. Dapat disimpulkan bahwa implementasi kegiatan ekstrakurikuler cilokaq dalam membangun karakter cinta tanah air di SMAN 1 Praya Timur dapat diwujudkan melalui menyanyikan lagu daerah Sasak yang berorientasi pada karakter cinta tanah air, penggunaan busana daerah suku Sasak, dan permainan alat musik tradisional suku Sasak cilokaq.
ANALISIS USAHA DAN EFISIENSI PEMASARAN PENGOLAHAN IKAN ASIN DI KAWASAN TOKO LIMA KECAMATAN MUARA BADAK
Authors: Mangalle Ingrid Maylivia , Syafril Muhammad , Susilo Heru
Published: January 2024

Pengolahan hasil perikanan dilakukan untuk menambah nilai ekonomis komoditi perikanan sehingga dapat meningkatkan harga jual komoditi ini selain untuk menjaga kualitas produk perikanan. Ikan asin merupakan satu diantara produk olahan hasil perikanan.  Penelitian ini bertujuan untuk menganalisis kelayakan usaha pengolahan ikan asin di kawasan Toko Lima Kecamatan Muara Badak berdasarkan indikator Revenue Cost Ratio (RCR), Payback Period (PP) dan Return on Investment (ROI), serta mengetahui pola saluran dan efisiensi pemasaran. Pengumpulan data dilakukan dengan melakukan pengamatan langsung di lapangan dan wawancara dengan responden berdasarkan kuesioner yang telah disiapkan. Hasil penelitian ini menunjukkan bahwa usaha pengolahan ikan asin di Kawasan Toko Lima Kecamatan Muara Badak menguntungkan dan berada pada kondisi layak untuk dilaksanakan. Jumlah rata-rata keuntungan yang diperoleh sebesar Rp. 15.579.063/bulan/responden dengan nilai RCR sebesar 1,73, payback period selama 11 bulan, dan ROI sebesar 109%. Pemasaran ikan asin menghasilkan dua saluran pemasaran yaitu saluran pemasaran tingkat I dan saluran pemasaran tingkat II. Efisiensi pemasaran setiap jenis komoditi berada diatas 50%, sehingga usaha pemasaran tersebut berada pada kondisi efisien dan layak untuk dilaksanakan.
ANALISIS DAYA SERAP LOGAM BERAT CUPRUM (CU) OLEH KIAMBANG (Salvinia molesta) DAN KAYU APU (Pistia stratiotes) DALAM PENGELOLAAN LIMBAH INDUSTRI
Authors: Nisa Andina Chairun
Published: January 2024

Perluasan kegiatan industri saat ini dapat berdampak positif terhadap kesempatan kerja, penyerapan tenaga kerja, dan pendapatan daerah. Namun, ada kekurangan seperti limbah industri yang jika tidak dikelola dengan baik dapat merugikan masyarakat. Metode alternatif pengolahan limbah melibatkan tanaman air. Tumbuhan fitoremediator atau yang dapat mengolah limbah secara biologis antara lain Kiambang (Salvinia molesta) dan kayu apu (Pistia stratiotes). Penelitian ini bertujuan untuk mengetahui konsentrasi logam berat Cuprum (Cu) yang dapat diserap oleh Kiambang (Salvinia molesta) dan kayu apu (Pistia stratiotes) pada konsentrasi 1 mg/l logam dalam media air selama 8 hari penanaman. Metode penelitian yang digunakan adalah metode eksperimen dengan Rancangan Acak Lengkap Faktorial. Variasi perlakuan yang digunakan yaitu Kiambang dan Kayu Apu sebagai faktor A dan durasi tanam sebagai faktor B. Data dianalisis menggunakan analysis of variance (ANOVA). Menurut hasil penelitian konsentrasi logam berat Cuprum (Cu) dalam air hingga 8 hari setelah tanam menurun menjadi 95,3 % pada perlakuan yang diberikan Kiambang dan 78,7 % pada perlakuan yang diberikan pada Kayu Apu. Parameter kualitas air seperti suhu, pH, dan kadar oksigen terlarut dalam air berada dalam kisaran yang baik untuk mendukung kehidupan tanaman selama masa pemeliharaan hingga 8 hari sebelum tanam.
PEMANFAATAN SILASE DAUN KELOR (Moringa oleifera) DALAM FORMULASI PAKAN TERHADAP EFISIENSI NUTRIEN DAN PERTUMBUHAN IKAN NILA (Oreochromis niloticus)
Authors: Akbarurrasyid Muhammad , Prajayati Vini Taru Febriani , Sofian Achmad , Sudinno Dinno , Prama Ega Aditya , Astiyani Wahyu Puji , Kristiana Indra
Published: January 2024

Daun kelor (Moringa oleifera) merupakan bahan baku lokal yang memiliki kandungan protein nabati sebesar 21,49% sehingga dapat dijadikan alternatif dalam penyusunan formulasi pakan buatan. Potensi penggunaan daun kelor sebagai bahan baku dalam formulasi pakan dapat dilakukan dalam bentuk silase. Penelitian ini bertujuan mengetahui pengaruh penggunaan dan persentase silase daun kelor dalam formulasi pakan terhadap efisiensi nutrient dan pertumbuhan ikan nila (Oreochromis niloticus). Penelitian dilakasana dengan menggunakan metode Rancangan Acak Lengkap dengan 4 perlakuan dan 3 kali ulangan. Penelitian dilakukan dengan mengindetifiksi potensi silase daun kelor, persiapan pakan perlakuan dan uji biologi terkait efesiensi nutrient dan pertumbuhan ikan nila. Hasil penelitian menunjukan pemanfaatan silase daun kelor memiliki potensi yang sama seperti pakan komersial terhadap efisiensi nutrient dan pertumbuhan ikan nila. Nilai efisiensi nutrient tidak menunjukan perbedaan signifikan antara pakan formulasi silase dan tanpa silase daun terhadap rasio konversi pakan dan retensi energi (P>0.05), sebaliknya mengalami perbedaan signifikan terhadap rasio efisiensi protein (P<0.05). Pertumbuhan ikan nila yang diperoleh tidak menunjukan perbedaan signifikan antara formulasi silase dan tanpa formulasi terhadap pertumbuhan bobot mutlak, Laju Pertumbuhan Spesifik (LPS) dan tingkat kelangsungan hidup (P>0.05), hal ini menujukan bahwa kualitas pakan formulasi silase sama dengan pakan tanpa formulasi tapi memiliki tingkat rasio efisiensi protein yang rendah.
A QUALIDADE DE ÁGUA NO LAGO DE BALBINA, PRESIDENTE FIGUEIREDO-AM
Authors: Fernandes Cristiane Nunes , Marinho Rogério Ribeiro
Published: January 2024

A Bacia Hidrográfica do rio Uatumã representa 1,13% da área da Bacia Amazônica, é formada pelo rio Uatumã, possui como formadores os igarapés Santo Antônio do Abonari e Taquari, e os principais tributários são os rios Pitinga e Jatapu (BALDISSERI, 2005). A partir de 1979 iniciou-se a construção da Usina Hidrelétrica (UHE) de Balbina, onde o alto curso do rio Uatumã foi represado e formou o lago de Balbina.
A UHE teve sua construção finalizada em 1987 para a atividade de produção de energia elétrica a partir de turbinas hidrocinéticas. É considerado um dos maiores erros ambientais da Amazônia, pois foi uma realização antrópica que provocou alterações na rede de drenagem afetando populações indígenas e ribeirinhas, além do impacto negativo na vegetação, gerando milhares de árvores “mortas” conhecidas como “paliteiros”. Esta floresta submersa e morta, emitem até hoje metano e contribui para o aumento de gases de efeito estufa (FEITOSA et al., 2015).
GEOGRAFIA E LITERATURA: A MIGRAÇÃO NARRADA NA OBRA A HORA DA ESTRELA, DE CLARICE LISPECTOR
Authors: Silva Dalila Naiara Costa Henrique da , Nogueira Amélia Regina Batista
Published: January 2024

O referido texto busca discutir o fenômeno social da migração representado na literatura clariceana, através da obra A Hora da Estrela, buscando ressaltar a relação epistemológica entre a linguagem literária e a ciência geográfica, a partir da abordagem teórico-metodológica da geografia humanista cultural, na perspectiva fenomenológica. Este ensaio objetiva refletir o ser migrante como um sujeito que transforma o espaço desconhecido de uma cidade em seu lugar vivido.
Neste sentido, buscaremos refletir a dimensão existencial da migração, unificando a teoria a partir da obra literária selecionada, que se materializa nas vivências dos migrantes internos ou migrantes interestaduais da cidade de Manaus.
Representar o processo dinâmico da migração através da arte literária nos conduz a um diálogo com outros campos de conhecimento, assim, buscar-se-á na literatura o ser-no-mundo.
CLIMA E SAÚDE: DIARREIAS AGUDAS E SEUS CONTEXTOS URBANOS DE TRANSMISSÃO EM MANAUS-AM
Authors: Castro Marcela Beleza de , Silva Neto João Cândido André da
Published: January 2024

este estudo buscou analisar as condições socioambientais que conferem risco e vulnerabilidade à incidência da diarreia aguda na cidade de Manaus, bem como identificar padrões de ocorrência da doença (período de incubação) com a sazonalidade hidroclimática, verificar as condições socioeconômicas e ambientais de transmissão, o perfil epidemiológico dos infectados e, por fim, a construção de um índice de risco e vulnerabilidade à doença para a cidade de Manaus.
O PAPEL DO PODER PÚBLICO NA VULNERABILIDADE AMBIENTAL DAS ÁREAS DE RISCO A VOÇOROCAMENTO EM MANAUS-AM
Authors: Molinari Deivison Carvalho , Vieira Antonio Fábio Sabbá Guimarães
Published: January 2024

O município de Manaus possui uma população de 2.063.547 habitantes distribuídos numa área territorial de 11.401 km² (IBGE, 2023). Deste total, aproximadamente 99,5% da população reside no setor urbano, ocupando apenas 4% da extensão territorial municipal, o que, portanto, demonstra a elevada densidade demográfica de Manaus de 4832,66 hab./km², quando comparada com a densidade do município de 180,99 hab./km².
A expansão da área urbana manauara e seus problemas ambientais são reflexos diretos e/ou indiretos da criação da Zona Franca de Manaus (ZFM) e da falta (ou não aplicação ou ineficácia) de políticas públicas habitacionais e ambientais. Sabe-se que a Zona Franca propiciou um novo ciclo econômico regional manifestado principalmente pelo crescimento econômico e pela elevada oferta de trabalho voltada basicamente para atender o parque industrial instalado. Essa reestruturação econômica motivou a migração de diversos amazônidas (RIBEIRO FILHO, 1999; OLIVEIRA, 2010a; OLIVEIRA, 2010b), principalmente do interior do Amazonas e/ou dos estados vizinhos, em especial dos municípios a oeste do estado do Pará, do Maranhão e do Ceará, com a esperança de oportunidades de emprego para a capital amazonense.
CONFORTO TÉRMICO E SAÚDE DOS CAMPONESES: ESTUDO DE CASO NA COMUNIDADE AGROVILA NO MUNICÍPIO DE TEFÉ-AM
Authors: Miranda Rozilene da Silva , Aleixo Natacha Cíntia Regina
Published: January 2024

A produção camponesa é extremamente importante para a agricultura do país, uma vez que segundo Serenini (2014) ela é responsável por 70% dos alimentos básicos consumidos pelos brasileiros, se fazendo fundamental para o desenvolvimento local, pois, parte de sua produção tem como destino final a comercialização para o mercado local e regional.
No município de Tefé, localizado a 522 km da capital do estado do Amazonas, a agricultura é indispensável para o seu desenvolvimento uma vez que ela contribui para a economia local, além de sua produção ser base alimentar para a população em geral. Apesar disso, a prática do seu trabalho gera impactos relevantes à saúde dos trabalhadores que executam essa atividade devido à precariedade e condições de trabalho que aos mesmos são impostos.
Com relação aos agravos à saúde, um dos fatores potencializadores relacionados ao trabalho no campo é o desconforto térmico devido às extensas jornadas de exposição direta aos raios solares. Leal et al. (2017) afirmam que o conforto térmico é determinado pela interação de variáveis ambientais e pessoais. As condições térmicas interferem no rendimento do trabalho dos indivíduos e podem provocar desconforto térmico, acarretando complicações associadas à saúde e bem-estar do indivíduo.
Management and use of Ash in Britain from the Prehistoric to the Present: Some implications for its Preservation
Authors: Jim Pratt
Published: January 2024

The properties that make the wood of fast-grown Ash pliable, strong, and resilient have been exploited by man for thousands of years, and are illustrated by reference to the probable use of Ash timber for tools, arms, and transport by the Roman Army of Occupation in Britain two thousand years ago. Militarily organized and disciplined, the Roman Army was responsible for changing the face of Britain with huge infrastructure projects that required significant numbers of tools, equipment, and fuel, in addition to the arms it used to maintain control over the fractious tribes of the north. The extent to which it maintained supplies of this valuable resource by managing its woods, possibly by coppicing, is discussed and raises the question as to the degree of genetic selection involved in coppicing. Ash: Fraxinus excelsior: extinction: prehistoric and historic uses: Roman army military use of Ash.
Case Series of Metastatic Cutaneous Malignant Melanoma to the Gallbladder and the First Reported Case of Metachronous Adenocarcinoma of the Colon
Authors: Nourdin Kadi , Abid Chowdhury , Matthew Hanks , Abed M Zaitoun
Published: January 2024

Two female patients in their fifties with a previous history of cutaneous malignant melanoma were found during follow-up to have a 'hot' lesion in the gallbladder on a Positron Emission Tomography scan. Imaging showed a gallbladder polyp. Histology revealed infiltration of the polyp mucosa by metastatic malignant melanoma. One case had a BRAF mutation. A male in his 70s was found on a staging computed tomography scan to have a suspicious intraluminal lesion in the gallbladder and thickening of the sigmoid colon. Subsequent histology confirmed metastatic malignant melanoma in the chest wall and to the gallbladder and adenocarcinoma in the colon. Molecular testing showed BRAF mutation. The metachronous adenocarcinoma in the colon was mismatch repair protein proficient and had no KRAS mutation. Histology from all cases showed that metastatic malignant melanoma to the gallbladder is superficial. Discussion: Reports from autopsy examinations revealed that metastasis from malignant melanoma to the gallbladder can be up to 15% - 20%. Most patients have mild symptoms or are asymptomatic which explains the paucity of cases reported in living patients within the published literature. Most of the previous reports showed the metastatic malignant melanoma to the gallbladder presented macroscopically as a polyploidal lesion. Conclusion: Our histological observation and previous reports showed that metastatic malignant melanoma in the gallbladder tends to be superficial. All our cases show no lymphatic or vascular invasion in the histological examination as previously published reports, however, the hematological spread is the most commonly suggested mechanism of spread.
Pediatric Dysgerminoma: Unveiling a Rare Ovarian Tumor
Authors: Faten Limaiem , Khalil Saffar , Ahmed Halouani
Published: January 2024

Background: Dysgerminomas, account for only 1% - 2% of all malignant ovarian neoplasms. Objective: This case report aims to present a rare occurrence of dysgerminoma in a pediatric patient, highlighting the clinical characteristics, diagnosis, and management. Case presentation: We present a case of dysgerminoma in a 12-year-old girl who presented with a three-week history of pelvic pain and progressive abdominal swelling. Physical examination revealed a distended abdomen with evident suprapubic fullness, and a palpable abdominopelvic mass measuring approximately 20 weeks in size. Imaging studies confirmed the presence of a solid heterogeneous mass originating from the pelvis. The patient underwent a right salpingo-oophorectomy without complications. Histological examination coupled with an immunohistochemical study confirmed the diagnosis of dysgerminoma. The patient had an uneventful postoperative course and was discharged without adjuvant treatment. Regular follow-up visits, physical examinations, ultrasound scans, and lactate dehydrogenase assays were initiated for monitoring. Conclusion: Prompt recognition and appropriate surgical intervention, followed by regular monitoring, are crucial for optimal outcomes in pediatric dysgerminoma cases.
Generation of Curved Spacetime in Quantum Field
Authors: Sarfraj Khan
Published: January 2024

To reach such a consistent theory which contains the quantum field theory of particle physics and Einstein’s theory of gravitation as limiting cases, one may proceed in the following way: Standard quantum field theory just ignores the effects of gravity. This is justified in many cases due to the weakness of gravitational interactions at the presently accessible scales. In a first step beyond this approximation, one may consider an external gravitational field that is not influenced by the quantum fields. Here one may think of sources of gravitational fields that are not influenced by the quantum fields under consideration, as high-energy experiments in the gravitational field of the earth or quantum fields in the gravitational field of dark matter and dark energy. This approach amounts to the treatment of quantum field theory on curved spacetimes. The problem of quantization in curved spacetimes is now clearly visible. In Minkowski spacetime, there is a large group of symmetries that enforces a particular choice of vacuum by demanding the vacuum to be invariant. Such a criterion is absent for a general spacetime (M,g). We therefore do not know which state to choose as the vacuum. One might hope that the different prescriptions might be unitarily equivalent such that it doesn’t matter which state one takes to define the theory. Sadly this is not the case: The Stone-Von Neumann theorem is no longer valid for systems with an infinite amount of degrees of freedom. This means that unitarily inequivalent representations of the canonical commutation relations will arise, and it is not clear which equivalence concept representation is the physical one. In the second section of this chapter, we review the notions of Cauchy surfaces and global hyperbolicity.
Quality by Design (QbD) in pharmaceutical development: A comprehensive review
Authors: Pratik B. Aru  , Mayur S. Gulhane  , Vinayak A. Katekar  , Swati P. Deshmukh
Published: January 2024

Quality by Design (QBD) represents a transformative approach to pharmaceutical development, emphasizing a systematic and science-driven methodology to ensure consistent product quality. This article explores various facets of QBD, ranging from its foundational principles to challenges, opportunities, and future perspectives. The journey begins with an introduction to QBD, outlining its key concepts and objectives. The article then delves into the key principles of QBD, such as the establishment of a design space and the importance of risk assessment. Real-time Release Testing (RTRT) is discussed as a critical element in ensuring product quality and consistency. Case studies are presented, showcasing successful implementations of QBD in drug development and highlighting their impact on product quality and regulatory compliance. The regulatory landscape is examined, focusing on expectations and requirements related to QBD, as well as the integration of QBD concepts into regulatory submissions. Challenges and opportunities associated with QBD implementation are thoroughly explored, addressing industry-wide adoption challenges and strategies to overcome resistance to change. Continuous improvement emerges as a central theme, with a focus on its role in refining processes, learning from experiences, and fostering a culture of innovation. The article then looks towards the future, discussing the integration of advanced technologies, including analytical tools and Industry 4.0, and their implications for QBD. Global harmonization efforts are examined, emphasizing collaborative initiatives and their impact on aligning regulatory expectations globally.
Artificial intelligence (AI) in renewable energy: A review of predictive maintenance and energy optimization
Authors: Shedrack Onwusinkwue  , Femi Osasona  , Islam Ahmad Ibrahim Ahmad  , Anthony Chigozie Anyanwu  , Samuel Onimisi Dawodu  , Ogugua Chimezie Obi  , Ahmad Hamdan
Published: January 2024

The integration of Artificial Intelligence (AI) in the renewable energy sector has emerged as a transformative force, enhancing the efficiency and sustainability of energy systems. This paper provides a comprehensive review of the application of AI in two critical aspects of renewable energy in relation to predictive maintenance and energy optimization. Predictive maintenance, enabled by AI, has revolutionized the renewable energy landscape by predicting and preventing equipment failures before they occur. Utilizing machine learning algorithms, AI analyzes vast amounts of data from sensors and historical performance to identify patterns indicative of potential faults. This proactive approach not only minimizes downtime but also extends the lifespan of renewable energy infrastructure, resulting in substantial cost savings and improved reliability. Furthermore, AI plays a pivotal role in optimizing the energy output of renewable sources. Through advanced data analytics and real-time monitoring, AI algorithms can adapt to changing environmental conditions, predicting energy production patterns and optimizing resource allocation. This ensures maximum energy yield from renewable sources, making them more competitive with traditional energy sources. The paper delves into specific AI techniques such as deep learning, neural networks, and predictive analytics employed for predictive maintenance and energy optimization in various renewable energy systems like solar, wind, and hydropower. Challenges and opportunities associated with implementing AI in renewable energy are discussed, including data security, interoperability, and the need for standardized frameworks. The synthesis of AI technologies with renewable energy not only addresses operational challenges but also contributes to the global transition towards sustainable and clean energy solutions. This review serves as a valuable resource for researchers, practitioners, and policymakers seeking insights into the evolving landscape of AI applications in the renewable energy sector. As technology continues to advance, the synergies between AI and renewable energy are poised to shape the future of the global energy paradigm.
A Classroom Interaction Analysis of Teacher and Students by Using FIACS
Authors: Sainyakit Paulus , Santoso Yan Imam
Published: January 2024

Classroom interaction plays an important role in the teaching and learning process. It is because it involves the interaction between teacher, student and student-student in which they influence each other in the classroom interaction. It is also said that classroom interaction gives a chance to ask, to guess, to think even to the course material in order to make interaction between the teacher and students their selves in the classroom. This research is aimed to analyze the classroom interaction by using FIACS. This research is included as a quantitative content analysis design. This research involves a teacher and the 2nd semester students of STKIP Terang Bangsa. The observation is employed in this research as the method of collecting data. After that, the data would be calculated by using a formula. The results show that the Teacher Initiated category is the highest dominant in the classroom interaction. It has 3.422 or 95,50% out of 3.583 interactions in the classroom. Then, the Student-Initiated category has 161 or 4,50% of the total. Lastly, the Student-student initiated category has no interactions. Due to the limitations of the research, the researcher suggests that future research on this topic should involve more participants in interacting not only teacher to student but student to student, so the conclusion can be drawn more valid.
Analisis Pengawasan Ketertiban Lalu Lintas Pada Daerah Rawan Kemacetan dan Kecelakaan di Kabupaten Gresik
Authors: Wibisono R Endro , Rizki Fitroh Maulana
Published: January 2024

Kabupaten Gresik merupakan salah satu kabupaten dengan tingkat kemacetan dan kecelakaan yang cukup tinggi sehingga perlu adanya analisis mengenai langkah kerja hingga penilaian pengawasan ketertiban lalu lintas. Metode penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif melalui survei pengamatan, wawancara dan studi pustaka serta pengolahan data. Tujuan penelitian ini adalah untuk mengetahui langkah kerja, pelaksanaan, permasalahan dan solusi pengawasan dan penilaian pengawasan pada daerah rawan kemacetan dan kecelakaan di Kabupaten Gresik. hasil pengamatan adalah Langkah kerja dan K3 yang menjadi pedoman oleh petugas pengawasan. Dalam pelaksanaan pengawasan terdapat beberapa data yang perlu diperoleh, diantaranya data lingkungan, data lalu lintas, data geometri, dll. Dalam perhitungan Kinerja ruas jalan perkotaan dengan menggambil salah satu lokasi dan diperoleh nilai derajat kejenuhan 0.43, kecepatan kendaraan ringan rata-rata dan indeks tingkat pelayanan jalan adalah B yaitu lalu lintas masih stabil. Namun, untuk peramalan untuk 5 tahun mendatang diperoleh nilai derajat kejenuhan 3.49, kecepatan rata â€“ rata kendaraan dan indeks tingkat pelayanan adalah F yaitu kondisi lalu lintas buruk. Permasalahan kerap kali muncul namun, akan diselesaikan dengan solusi yang berdasar pada hasil diskusi. Kriteria penilaian pelaksanaan pengawasan terdiri atas penilaian ketepatan, kedisiplinan, Kesesuaian Petugas dalam melaksanakan tugas pengawasan ketertiban lalu lintas dan keakuratan.
ANALISA PERKUATAN LERENG PADA TANAH LUNAK YANG DIPENGARUHI OLEH KEMIRINGAN LERENG DAN JUMLAH LAPIS GEOTEKSTIL
Authors: Muzaidi Irwandy , Anggarini Elia
Published: January 2024

Kondisi lereng dengan beban yang besar dan kemiringan yang curam dapat menyebabkan terjadinya kelongsoran sehingga diperlukan suatu perkuatan lereng, salah satunya dengan menggunakan geotekstil. Geotekstil sering digunakan karena memiliki beberapa keunggulan, diantaranya adalah mudah dalam pelaksanaan dan dapat meningkatkan stabilitas lereng dengan efektif. Penelitian ini bertujuan untuk mengetahui pengaruh kemiringan lereng dan jumlah lapis geotekstil terhadap angka keamanan lereng (SF) dengan menggunakan program geoslope. Hasil analisis yang didapatkan dari program Geoslope dengan kemiringan lereng 45Â° tanpa adanya perkuatan didapatkan nilai SF adalah 0,784 dan tegangan air pori 32,415 dan pada kemiringan lereng 65Â° tanpa adanya perkuatan nilai SF adalah 0,714 dan tegangan air pori 39,686, Sedangkan untuk perkuatan 1 lapis pada kemiringan 45Â° didapatkan nilai SF 0,923 dan tegangan air pori 61,786 dan pada kemiringan lereng 65Â° didapatkan nilai SF 0,813 dan tegangan air pori 61,786, dengan perkuatan 2 lapis pada kemiringan lereng 45Â° didapatkan nilai SF 0,979 dan tegangan air pori 61,786 pada kemiringan lereng 65Â° didapatkan nilai SF 0,866 dan tegangan air pori 61,786, kemudian dengan perkuatan 3 lapis pada kemiringan 45Â° didapatkan nilai SF 1,022 dan tegangan air pori 61,786,Â  pada kemiringan lereng 65Â° didapatkan nilai SF 0,917 dan tegangan air pori 61,786. Berdasarkan hasil penelitian didapatkan kenaikan pada kemiringan lereng 45Â° dan 65Â° setelah adanya perkuatan geotekstil seiring dengan bertambahnya lapisan geotekstil.
PENGGUNAAN SODA ASH UNTUK PENINGKATAN KUALITAS AIR GAMBUT PADA BETON
Authors: Efendy Syahrial
Published: January 2024

Air gambut sering digunakan sebagai komponen bahan pencampur beton di wilayah Palangka Raya. Air adalah komponen penting dari bahan pencampur beton. Air gambut sebenarnya tidak disarankan untuk digunakan dalam pencampuran beton karena bersifat asam dan bahan organik yang dikandungnya dapat merusak beton. Garam natrium dari asam karbonat, juga dikenal sebagai soda abu atau natrium karbonat Na2CO3, mudah larut dalam air dan menghasilkan larutan alkali atau basa yang kuat. Ph air gambut dapat diubah dengan menambahkan soda abu, yang juga dapat mengurangi konsekuensi negatif dari penggunaan air gambut untuk pencampuran beton. Penelitian ini menggunakan teknik eksperimen untuk menentukan kemanjuran tekan dan porositas beton menggunakan air gambut yang telah ditambahkan soda ash dengan variasiÂ  pH Air 6,5 ;7,5 ;8,5 dan tanpa penambahan soda ash. Berdasarkan hasil penelitian,Â  penambahan variasi soda ash ke air pH rendah dengan 0,420 g/l diperoleh pH 6,65 ; 0,470 g/lÂ  diperoleh pH 7,52 ; 0,511 g/l diperoleh pH 8,34. Hasil pengujian yang dilakukan kuat tekan dan porositas pada beton tanpa penambahan soda ash terjadi penurunan kuat tekan beton pada usia perendaman 56 hariÂ  sebesar 26 % dan terjadi peningkatan selisih persentase porositas sebesar 0,115 %. Kuat tekan beton dengan penambahan variasi soda ash mengalami peningkatan seiring lamanya umur perendaman. Kuat tekan beton tertinggi diperoleh pada beton dengan pH air 6,5Â  sebesar 37 MPa di umur perendaman 56 hari. Presentase porositas dengan penambahan variasi soda ash, seiring lamanya perendaman semakin kecil. Variasi terkecil diperoleh pada beton dengan pH air 6,5 dengan selisih persentase 0,027%.
PENGARUH KOMUNIKASI YANG BURUK TERHADAP PELAKSANAAN PROYEK KONSTRUKSI DI KOTA LAMONGAN
Authors: Wazir Maulana Albi
Published: January 2024

Komunikasi dalam suatu proyek merupakan suatu kunci keberhasilan dalam pengelolaan proyek. Kesalahan atau kurang baiknya pola komuniksai dalam suatu proyek dapat berdampak pada kinerja yang kurang baik. Penelitian ini bertujuan untuk menganalisa keberhasilan proyek yang ditinjau dari sisi komunikasi antara pihak pemilik proyek, kontraktor dan konsultan. Variabel independen yang dipakai dalam penelitian ini adalah komunikasi dalam penggunaan biaya, komunikasi dalam penyaluran material, dan komunikasi dalam perancangan jadwal. Variabel dependen yang digunakan adalah komunikasi untuk penunjang keberhasilan proyek. Sampel pada penelitian ini adalah 31 orang yang terlibat langsung pada proyek konstruksi yang ada di kota Lamongan. Hasil dari penelitian yang sudah dilakukan adalah seluruh variabel independen berpengaruh terhadap variabel dependen, dan variabel yang paling dominan berpengaruh terhadap variabel dependen adalah komunikasi dalam penyaluran material dengan nilai koefesien regresi 0,618. Secara simultan terdapat pengaruh yang signifikan antara variabel independen terhadap variabel dependen dengan hasil nilai F hasil penghitungan dibandingkan dengan Ftabel, maka Fhitung hasil penghitungan lebih besar daripada Ftabel (28,072> 2,960). Secara parsial terdapat pengaruh yang signifikan antara masing- masing variabel independen pembentuk model regresi linier secara individu terhadap variabel dependen.
Klasifikasi Ragam Kendaraan Menggunakan Metode Convolutional Neural Network (Cnn)
Authors: Prasetyo Muhammad Eko , Faza Muhammad Reyno , Pratama Rifki , Alhabsy Said Nabil Hasan , Purwanti Hani , Masa Amin Padmo Azam
Published: January 2024

Proses klasifikasi citra ragam kendaraan menjadi suatu tantangan yang menarik untuk dilakukan penelitian. Proses klasifikasi ragam kendaraan banyak digunakan diberbagai banyak hal seperti pada proses e-tilang, e-parkir, maupun pada bidang yang lainnya. Salah satu metode yang biasa digunakan untuk proses klasifikasi adalah menggunakan metode Convolutional Neural Network (CNN). Metode CNN banyak digunakan untuk melakukan proses klasifikasi karena teruji dan telah terbukti efektif dalam pengolahan citra dan pengenalan pola. Dalam klasifikasi ragam kendaraan, CNN mampu mengekstrak fitur secara otomatis dan mengenali pola kompleks dalam data citra. Metode CNN memberikan efisiensi dan akurasi yang tinggi dalam klasifikasi ragam kendaraan, dengan berbagai aplikasi praktis seperti pengawasan lalu lintas dan sistem pengenalan plat nomor. Penelitian yang dilakukan yaitu melakukan pengenalan citra kendaraan bermotor untuk mengetahui jenis kendaraan roda dua (motor) dan kendaraan roda 4 (mobil) dengan menggunakan kombinasi metode otsu thresholding dan CNN. Hasil dari penelitian yang telah dilakukan dapat melakukan pengenalan kedua jenis kendaraan tersebut dengan baik dengan menampilkan tingkat keyakinan pada proses klasifikasi.
Pengukuran Tingkat Kepuasan Pengguna terhadap Website Sistem Pengadaan Secara Elektronik (SPSE) menggunakan Metode PIECES
Authors: Nanda Nidya Putri , Islamiyah  , Kamila Vina Zahrotun
Published: January 2024

Sistem Pengadaan Barang dan Jasa Secara Elektronik (SPSE) yaitu sebuah website yang dikelola oleh bidang Layanan Pengadaan Barang dan Jasa Secara Elektronik (LPSE) untuk meningkatkan akses informasi kepada masyarakat, mengembangkan media teknologi informasi dalam rangka menunjang pertumbuhan ekonomi dan pelestarian budaya, dan meningkatkan pemberdayaan teknologi informasi, pos dan telekomunikasi dalam rangka pelayanan publik. Tujuan dari penelitian ini untuk menghitung tingkat kepuasan pengguna terhadap website Sistem Pengadaan Secara Elektronik (SPSE) sekaligus menjadi bahan pertimbangan pengembangan dan perbaikan sistem menjadi lebih baik lagi. Penelitian ini bersifat kuantitatif yang menggunakan metode PIECES yaitu (Performance, Information and Data, Economics, Control and Security, Efficiency, serta Service). Hasil penelitian ini berhasil mendapatkan total rata-rata tingkat kepuasan pengguna dari semua variabel yaitu nilai 3,95 yang berarti bahwa pengguna sudah merasa puas dalam menggunakan website SPSE. Selanjutnya pada variable Control and Security mendapatkan nilai terendah 3,73 yang dapat dijadikan rekomendasi untuk  pengembangan dan perubahan prioritas dalam website SPSE kedepannya.
Aplikasi Proses Pembelajaran Mahasiswa Keperawatan Berbasis Android
Authors: Aristoteles Aristoteles , Kusuma Abie Perdana , Irawati Anie Rose , Sakethi Dwi , Suarni Lisa
Published: January 2024

Perawat adalah tenaga profesional yang dalam memberikan pelayanan medis menggunakan proses ilmiah yang disebut keperawatan. Dalam keperawatan, pemecahan masalah menggunakan proses keperawatan yang merupakan metode berfikir kritis, selama ini perawat harus menganalisis data-data yang ditemukan pada pasien untuk mendiagnosis, menentukan rencana luaran dan intervensi dengan tepat. Mahasiswa yang merupakan calon perawat dengan keahliannya harus mampu menerapkan proses keperawatan dalam kinerja asuhan keperawatan sesuai dengan standar keperawatan yang ada, tentunya dengan adanya pengawasan oleh ahli pengajar keperawatan untuk menghasilkan tenaga perawat yang lebih baik dalam upaya meningkatkan kualitas pelayanan medis. Penelitian ini bertujuan untuk mengembangkan aplikasi android dengan bantuan expert system sebagai alat bantu diagnosa keperawatan, yang membantu mahasiswa keperawatan dalam mempelajari proses keperawatan dan membantu dosen dalam pemantauan proses keperawatan yang dilakukan oleh mahasiswa calon perawat. Sistem pakar menggunakan metode forward chaining, dan pembangunan aplikasi menerapkan metode waterfall. Hasil dari penelitian merupakan aplikasi berbasis android yang diuji menggunakan metode blackbox testing.
Analysis of New 4D Hyperchaotic Systems MACM and Implementation Using Runge-kutta
Authors: Abdullah Taufik , Aqila Aqila , Karo Karo Ichwanul Muslim
Published: January 2024

In general, hyperchaotic system is defined as a chaotic system with more than one positive Lyapunov exponent, this implies that its chaotic dynamics extend in several different directions simultaneously. The discovery of reliable and effective methods for solving hyperchaotic systems is carried out extensively. The aim of this research is to implement nonlinear hyperchaotic using runge-kutta. The NHS system is built by inspecting, modifying and adding one state to the MACM chaotic system. In this study, we use the same initial conditions x_0=y_0=z_0=w_0=1 and the parameters a = 2,b = 2,c = 0.5, and d = 14.5. At first we experiments modified approaches, namely Classic Runge-Kutta Method 3 Order, Runge-Kutta Method Based On Arithmetic Mean, Metode Runge-Kutta Method Based On Geometric Mean, Modified Runge-Kutta Geometric Mean Based Method-1, RKLCM Approaches Instead of RKGM using MAPLE software as a calculation tool. In this work, we observe that the Runge-Kutta Method Based on Arithmetic Mean has the smallest error value with an average variable x of 0.000606953, variable y of 0.009280181, variable z of 0.000378639 and variable w of 0.60781585. Then also in RKLCM Approaches Instead of RKGM it has the largest error value with an average variable x of 0.483789793, variable y of 0.620803849, variable z of 0.92097139, and variable w of 0.596137549.
Klasifikasi COVID 19 dengan Metode EfficientNet berdasarkan CT scan Paru-paru
Authors: Irsyad Akhmad , Islamiyah Islamiyah , Setyadi Hario Jati , Amal Fakhmul
Published: January 2024

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) adalah virus penyebab Covid-19. Covid-19 adalah virus mematikan yang oleh Organisasi Kesehatan Dunia (WHO) ditetapkan sebagai pandemi karena penyebarannya yang cepat. Dua metode yang kini paling sering digunakan untuk mendeteksi Covid-19 adalah Rapid Diagnostic Test (RDT) dan Real-Time Reverse Transcription Polymerase Chain Reaction (RT-PCR). Menemukan strategi baru yang cepat dan tepat sangat penting karena kedua strategi memiliki kelebihan dan kekurangan. Penggunaan CT scan untuk menemukan Covid-19 adalah salah satu metode yang direkomendasikan. Makalah ini merekomendasikan identifikasi Covid-19 pada gambar CT menggunakan EfficientNet B0. tampil lebih unggul dari model tanpa CLAHE. Untuk performa EfficientNet B0 dengan CLAHE, akurasi, F-measure, recall, dan precision adalah 91,95%, 92,06%, 92,43%, dan 91,69%.
Sistem Pendukung Keputusan Rekomendasi Penginapan di Kawasan Pariwisata Guci Menggunakan Metode Vikor
Authors: Surorejo Sarif , Aini Atika Qurrotu , Gunawan Gunawan
Published: January 2024

Guci merupakan destinasi wisata yang terkenal dengan keindahan alamnya, seperti air terjun, sumber air panas dan pemandangan alam yang menakjubkan. Dengan semakin banyaknya pengunjung dari berbagai daerah, penting bagi pengunjung untuk bisa mendapatkan rekomendasi penginapan yang sesuai dengan preferensi dan kebutuhannya. Namun dalam memilih penginapan di kawasan Guci, pengunjung seringkali dihadapkan pada berbagai pilihan yang rumit. Mereka harus mempertimbangkan faktor-faktor seperti lokasi, fasilitas, dan harga. Keputusan ini bisa jadi sulit dan memakan waktu. Kemudian dirancanglah Sistem Pendukung Keputusan yang bertujuan untuk memberikan rekomendasi penginapan di kawasan Guci Tegal. Metode yang digunakan dalam sistem ini adalah VIKOR yang membantu pengunjung dalam memilih penginapan yang sesuai dengan kriteria yang diinginkan. Sistem Pendukung Keputusan ini akan membantu pengguna dalam mengambil keputusan dengan memberikan rekomendasi akomodasi terbaik berdasarkan semua kriteria. Metode VIKOR akan memberikan rekomendasi penginapan terbaik sesuai preferensi pengunjung.