bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategic imperatives of planning of higher education institutions development
Authors: Polyanska Alla S. , Tymoshenko Dmytro V.
Published: February 2023

The authors substantiate the importance of working out the strategy for the development of higher education institutions (HEI) in Ukraine. The purpose of this publication is the theoretical justification of the importance of developing a strategy for a higher education institution, determining priorities for its functioning and development, with the subsequent allocation of criteria for the formation of competitive advantages of the HEI. It will contribute to collective inspiration, systematic thinking and the disclosure of the talents of the faculty and students, and settling the tasks of Ukraine’s future progress. In order to achieve the purpose, the authors determine the concept of imperative as a criterion for strategic planning of an HEI development, based on the consideration of development priorities and grounded by objective preconditions and subjective vision of the ways to realize selected strategic priorities. It is emphasized that the present-day priorities of the higher education development should take into account the achievements of world practice, the trends of global development, the peculiarities of the domestic market of educational services, trends in the development of the national science as well as the preconditions for the formation and development of human capital. The peculiarities of philosophical and organizational-managerial concepts underlying the formation of an organization’s strategy are considered and identified, followed by their practical evaluation for HEI. The authors outline the methodological basis for strategic planning that can be used to develop HEI strategies. The process of strategic planning of HEI development is generalized, highlighting the main stages involved in the formation of a strategy based on the system approach application.
“Academic Capitalism”: Pros and Cons of the Development of Science and Higher Education
Authors: Romanovskyi Oleksandr O. , Romanovska Yuliia Yu.
Published: February 2023

The environment of academic capitalism, which has covered almost the entire field of science and higher education, has both positive (PROS) and negative (KONS) influences on them. Academic capitalism has sharply accelerated the commercialization of the results of applied research and development of universities and research institutes and has allowed these organizations and institutions to significantly capitalize on their intellectual capital. This gave impetus to the development of progressive innovations and outstanding inventions. For example, in the system of higher education there is an intensive innovative development, which, of course, can be attributed to the positive impact of academic capitalism on the development of material, technical, scientific and engineering potential of universities and colleges.On the other hand, the pursuit of profit and the general search for opportunities to commercialize R&D results, mainly the results of applied research and experimental development, leads to a significant reduction in demand and attention to the development of fundamental science and the search for basic scientific values. This leads to a slowdown in the production of new basic fundamental knowledge and a slowdown in the intellectual development of society.Many recent scientific publications have also criticized the impact of academic capitalism on science and higher education. Excessive entrepreneurial activity of universities in the direction of profiting from the development and commercialization of applied research instead of purely scientific activities and basic basic research leads to the loss of the position of universities and colleges as “temples of science”. There may still be a small number of academic institutions of higher education and research that continue to conduct basic research that is difficult to commercialize but that is genuine “scientific knowledge,” or in other words, knowledge of humanity.This paper analyzes the innovative changes in the higher education system caused by the environment of academic capitalism. The negative impact of academic capitalism on the sphere of higher education and science is also analyzed.
Teaching Multi-Stakeholder Sustainable Innovation
Authors: Thomas Paul R.
Published: February 2023

Higher education has a crucial role to play in the global transition sustainable devbelopment. A shift from an educational paradigm that teaches linear and unsustainable innovation activity, to one that teaches circular and sustainable innovation activity, is a fundamental requirement if global sustainable development goals are to be met through future innovation. The educational model currently forming the foundation for most MBA programs remains primarily focused on teaching maximization of shareholder profit within a private, for-profit business context. A ‘sustainable’ business is usually defined as one that has successfully met purely financial goals for the benefit of shareholders, often ignoring other vital stakeholder interests, most importantly: natural, human and social capital. On the base of UACU we grounded that today models of business instruction must focus student innovation activity on the design and implementation of multi-stakeholder innovations. Innovations that meet a need or solve a problem within foundational sectors of civilization. Innovations that are adaptable and applicable to widely divergent sectors, from private for-profit business to social charities. Business education must be built upon a foundation of analytic skills, an ethical framework, and a commitment to promoting ‘sustainable’ innovations.
Gerçek Dünya’da Kendini Evinde Hissetmeyenlere Yeni Bir Dünya: "Başlat: Ready Player One" Filmine Bir Bakış
Authors: AYDINALP Prof Dr. Şükran Güzin Ilıcak
Published: February 2023

“OASIS’i yarattım çünkü gerçek dünyada kendimi hiç evde hissetmedim, insanlarla nasıl bağ kurulur bilemedim. Gerçeklik çok korkutucu ve acı veren bir yer olsa da düzgün bir yemek yiyebildiğim tek yer. Gerçeklik gerçektir”. OASIS dünyasının mucidi dahi James Halliday (Mark Rylance) “Ready Player One” filmin son sahnelerindeki repliğiyle aslında filmi ve vermek istediği mesajı çok güzel bir biçimde özetliyor. Film yalnız, arayış içinde, mutsuz ve kendini gerçek dünyaya ait hissetmeyen bireylerin, haz yaşamak üzere ütopik bir dünyaya adım atması ve sonrasında bu dünyayı da eleştirmelerini ele alıyor.
Percepción sobre la enseñanza presencial y el aprendizaje virtual en pre y pospandemia
Authors: Rodriguez Velasquez Jaime Ricardo , Flores Marchan Dr Guido , Mora Santiago Dr Ruben Jose , Riquez Livia Dr. Pablo , Villena Rojas Mag Moisés Alberto
Published: February 2023

El objetivo del presente estudio titulado Percepción sobre la Enseñanza Presencial y el Aprendizaje Virtual en pre y pospandemia

Nos ha permitido hacer un estudio comparativo entre la opinión de la percepción sobre estas dos variables. Logramos analizar la percepción sobre la enseñanza virtual y luego sobre el aprendizaje virtual en un grupo de 185 estudiantes de las promociones de estudiantes de educación física: 2016, 2027y 2018 de los cuales el mayor porcentaje de los estudiantes eran varones cuya edad promedio es entre los 19 y 25 años. el estudio se concretizo mediante aplicación de un cuestionario denominado ENCUESTA JRV 21 con un total de 30 ítems.  Nuestra hipótesis central fue determinar el nivel de pr4eferenvia entre la enseñanza presencial frente al aprendizaje virtual en la percepción de los estudiantes en mención, la respuesta fue contundente los estudiantes prefieren el proceso pedagógico el cual debería estar basado en la enseñza presencial con una diferencia significativa en las medias y en la desviación estándar entre estos dos tipos de trabajo didáctico., esto se demuestra en los tres grupos de nuestra muestra. Por lo tanto, se acepta la hipótesis de trabajo donde se señala que si existe diferencias significativas. En valores de 45 puntos de enseñanza ´presencial frente a 39 de aprendizaje virtual.  Así mismo la opinión sobre la enseñanza presencial es más homogénea que en el aprendizaje virtual, esto demostrado en el nivel de desviación estándar de los dos grupos, en valores de 4.99 de enseñanza presencial frente a 6.99 de aprendizaje virtual
Establecimiento de diversos esquemas de promoción y crecimiento de parajes turísticos en Tamazunchale, San Luis Potosí, México
Authors: Fernández Pérez Tejada Mtro. Oscar , Olivares Bazán Mtro. León Donizetty , Amaro Hernández Mtro. José Alejandro , Sánchez Miguel Dra. Denison Selene , Espinoza Hernández Mtro. Jaime
Published: February 2023

El presente proyecto de investigación presenta una temática relacionada con el desarrollo del Turismo en Tamazunchale, San Luis Potosí, México, con el fin de establecer de diversos esquemas de promoción y crecimiento de parajes turísticos. Se desarrollo una propuesta de estructura de proyecto de desarrollo local con la información proporcionada por el Ayuntamiento de Tamazunchale y con los resultados obtenidos de la matriz FODA, aunado a lo anterior, también se realizó un muestreo no probabilístico por conveniencia para recolectar información de los empresarios que se dedican a este giro del turismo y se les entrevisto.
Improving speaking skills by implementing self-assessment and self-regulation facilitated by whatsapp in 8th year students
Authors: Vera Sánchez Diana Maritza , Pinargote Sánchez María Juliana , Lara Alcívar Dolores Katerine
Published: February 2023

This study aimed to improve the Speaking skills of a group of young learners by implementing Self-regulation and Self-assessment facilitated by WhatsApp. Students could upload five audios and self-assess their learning. The sample involved twenty-eight 8th-grade learners with an A1 English level from a public school in Pedernales, Manabi. The facilitator provided meaningful activities designed in a lesson plan, where learners, through effective practice, uploaded and self-assessed their work contrasting them against a rubric, obtaining a significant and positive effect size of 2.42 as the global speaking skill improvement at the final part of the innovation. Findings also showed a significant improvement in teacher and students' average scores on the audio, with a slight difference between both means. The instruments included a pre & post-test, a rubric, a checklist, and an interview. Since self-regulation was beneficial, EFL teachers may find the results and discussion of this research valuable for its implementation in classes.
La dialéctica de los cambios ambientales El antagonismo del cambio climático
Authors: García Saldaña Arturo , Alcantara Mendez Virginia , Mata Alejandro Humberto
Published: February 2023

El ensayo presenta al Panel Intergubernamental del Cambio Climático y al grupo antagónico de científicos Escépticos que promueven el Calentamiento Global. El objetivo fue analizar ambas posturas que tratan del origen o causas de los cambios ambientales que existen a la fecha. Se revisó literatura en diferentes bases de datos para argumentar sus características a través del ejercicio epistémico que aplica la dialéctica crítica en la comparación de los conceptos Cambio Climático y Calentamiento Global. Como resultado se elaboró la síntesis para comprender ambas posturas analizadas desde sus fortalezas como resultado del pensamiento crítico. El ensayo contribuye para que los lectores comprendan y se apropien de perspectivas claras de las posturas, con respecto de temas en común. Además, fueron proporcionadas las bases para crear conciencia con respecto a la temporalidad de los cambios en el medio ambiente, sus efectos, consecuencias y su mitigación. Se concluyó que aún en la actualidad, aunque se observan los efectos comprobados o no de un desequilibrio ecológico, existe una realidad en la mayoría de la humanidad de una falta de conciencia colectiva dañina para los seres vivos y el medio ambiente.
Estrategias de puesta en valor turístico de las lagunas y cascadas de la región Lambayeque-Perú
Authors: Rodríguez-Serquén Segundo Arturo
Published: February 2023

En la presente investigación se encontraron estrategias de puesta en valor turístico de las lagunas y cascadas que poseen las comunidades de Laquipampa (Incahuasi), Mayascón (Pítipo), El Espinal (Oyotún) ubicadas en la Región Lambayeque-Perú, atractivos naturales de los más cotizados por el turista moderno, con la finalidad de integrarlas al circuito turístico nacional y viabilizar a través del turismo el desarrollo socio-económico de las comunidades mencionadas. Ello se logró después de registrar la oferta turística existente y potencial e identificar las necesidades prioritarias en materia de servicios básicos, infraestructura y recursos humanos requeridos por el turista. La investigación tuvo un enfoque cualitativo, de corte transversal, descriptivo y exploratorio; el método de investigación empleado fue del tipo inductivo. Se empezó efectuando una amplia indagación bibliográfica, visitas de campo y practicando entrevistas y cuestionarios  acerca de la oferta turística y la infraestructura existente. Luego se analizó y ejecutó un  diagnóstico con la información para finalmente plantear estrategias de marketing, de gestión de inversión pública y privada, de capacitación turística y de desarrollo sostenible para la puesta en valor de los valiosos recursos naturales de las comunidades. Las estrategias encontradas posibilitarán el desarrollo de las comunidades rurales empobrecidas del país objeto de estudio, dueñas de ricos escenarios naturales, valores culturales ancestrales y también importantes lugares arqueológicos.
Cost-effectiveness of Tamoxifen versus Anastrozole in post-menopausal women with breast cancer: Saudi Arabia perspective
Authors: Alharbi Adnan
Published: February 2023

Background: Tamoxifen and Anastrozole are widely used as adjuvant therapy for Hormone-sensitive early breast cancer patients. Although these medications are expensive, we lack cost-effectiveness analysis to inform decision-making.
Aim: We aim to assess the cost-effectiveness of Anastrozole versus Tamoxifen for the adjuvant therapy of hormone-positive tumors among postmenopausal women with early breast cancer.
Methods: A probabilistic Markov model was built considering The Arimidex, Tamoxifen, Alone, or in Combination (ATAC) trial outcomes for the model assumptions. The model is built from the Saudi perspective. Probabilistic sensitivity analysis was conducted for uncertainty.
Results: Anastrozole has been cost-effective with an incremental cost-effectiveness ratio of 80333.88 SAR/quality-adjusted life-year at a Willingness-to-pay of 100,000 USD (equivalent to 375,000 SAR). The probabilistic sensitivity analysis was conducted, and Anastrozole was still cost-effective under changing parameters.
Conclusion: Anastrozole offers a cost-effective adjuvant option for hormone-positive early breast cancer patients and can be considered for reimbursement.
DEVELOPMENT OF THE STRUCTURE OF AN AUTOMATED SYSTEM FOR DIAGNOSING DISEASES
Authors: Myrzakerimova Alua , Kolesnikova Katerina , Nurmaganbetova Mugulsum
Published: February 2023

Today, the importance of information support for various medical technologies has increased significantly. The use of modern information technologies is becoming a critical factor in the development of most branches of knowledge and areas of practice, so the development and implementation of information systems is an urgent task. The clinical decision support system provides clinicians and stakeholders with individualized patient assessments and recommendations to assist in the clinical decision-making process.

Knowledge-based information systems are widely used in medicine around the world. Modern technical capabilities make it possible to reach a qualitatively new level of presentation of the course of the disease, namely, based on appropriate mathematical models, to model the typical development of the pathological process in a particular disease, to speed up the process of diagnosing and receiving recommendations on treatment protocols.

In Kazakhstan, there is no variety of decision support systems in medicine, especially in the process of diagnosing diseases. The purpose of this study is to develop the structure of an automated system for diagnosing diseases. The Unified Modeling Language (UML) is used as a design tool. The structure of the automated system is presented; the main components and key terms are considered. A mathematical model of diagnostics is shown (in the example of diseases of intestinal and pancreatic insufficiency) based on decision-making methods with fuzzy initial data. A diagram of the data flows of the system is presented. Thus, the paper proposes the structure of an automated system that will contribute to high-quality diagnostics due to an effective method of system organization and the use of fuzzy set theory methods.
Trajetória ocupacional de serviços de tecnologia da informação e bem-estar social no Poder Executivo brasileiro entre 2004 e 2019
Authors: Silveira Leonardo
Published: February 2023

Este estudo faz uma descrição da participação de grupos ocupacionais e profissionais no Poder Executivo nas esferas federal, estadual e municipal entre 2004 e 2019. Com isso, tem-se o foco em áreas do Estado de bem-estar social (saúde e educação) e ocupações tecnológicas. Além disso, observa-se se as tendências deste intervalo são similares nos municípios, dependendo do seu tamanho.
NT - 92 - Diset - Políticas públicas para ciência e tecnologia no Brasil : cenário e evolução recente
Authors: De Negri Fernanda
Published: February 2023

Antes de analisarmos a evolução dos investimentos públicos e privados em P&D no país, é necessário elaborar um quadro geral das principais políticas públicas adotadas no país para estimular essas atividades, bem como suas principais fontes de recurso e as instituições responsáveis por sua execução.
NT - 98 - Disoc - Mortalidade por covid-19 e queda do emprego no Brasil e no mundo
Authors: Hecksher Marcos
Published: February 2023

Para situar no contexto mundial a intensidade relativa de danos causados pela covid-19 no Brasil, esta nota compara alguns indicadores, ressaltando suas principais limitações e vantagens. O Brasil registrou, em proporção de sua população total, mais mortes por covid-19 em 2020 do que 89,3% dos demais 178 países com dados compilados pela Organização Mundial de Saúde (OMS). Quando a comparação desses registros é ajustada à distribuição populacional por faixa etária e sexo em cada país, o resultado brasileiro se torna pior que os de 94,9% dos mesmos 178 países. Com base em dados de nível de ocupação compilados pela Organização Internacional do Trabalho (OIT), o Brasil registrou queda do indicador mais intensa do que as de 84,1% dos demais 63 países analisados entre os três últimos trimestres de 2019 e de 2020.
The performance of radar absorption of MnxFe3–xO4/rGO nanocomposites prepared from iron sand beach and coconut shell waste
Authors: Prakasa Yana Fajar , Sumari Sumari , Santoso Aman , Asrori Muhammad Roy , Cahyanti Ririn
Published: February 2023

In this work, the Fe3O4 nanoparticles from natural iron sand were doped with Mn and combined with reduced-graphene oxide (rGO) to obtain MnxFe3–xO4/rGO nanocomposites with mole fraction variations of the Mn of 0.25, 0.5, and 0.75. The crystalline phase of the synthesized MnxFe3–xO4/rGO nanocomposites formed an amorphous phase. The presence of rGO was observed through EDX results. The magnetical properties of MnxFe3–xO4/rGO nanocomposites were shown by decreasing the Br, HcJ, Hmax along with increasing of Mn doping. Interestingly, increasing rGO and Mn composition made the absorption bandwidth of the MnxFe3–xO4/rGO nanocomposites wider, so that the radar absorption also increased marking by the greater reflection loss that reached −11.95 dB. The increase in the radar absorption performance of MnxFe3–xO4/rGO nanocomposites came from the efficient complementarity between dielectric loss and magnetic loss and interfacial polarization between Fe3O4 doped Mn and rGO.
q-Spherical fuzzy rough sets and their usage in multi-attribute decision-making problems
Authors: Azim Ahmad Bin , ALoqaily Ahmad , Ali Asad , Ali Sumbal , Mlaiki Nabil , Hussain Fawad
Published: February 2023

This article's purpose is to investigate and generalize the concepts of rough set, in addition to the q-spherical fuzzy set, and to introduce a novel concept that is called q-spherical fuzzy rough set (q-SFRS). This novel approach avoids the complications of more recent ideas like the intuitionistic fuzzy rough set, Pythagorean fuzzy rough set, and q-rung orthopair fuzzy rough set. Since mathematical operations known as "aggregation operators" are used to bring together sets of data. Popular aggregation operations include the arithmetic mean and the weighted mean. The key distinction between the weighted mean and the arithmetic mean is that the latter allows us to weight the various values based on their importance. Various aggregation operators make different assumptions about the input (data kinds) and the kind of information that may be included in the model. Because of this, some new q-spherical fuzzy rough weighted arithmetic mean operator and q-spherical fuzzy rough weighted geometric mean operator have been introduced. The developed operators are more general. Because the picture fuzzy rough weighted arithmetic mean (PFRWAM) operator, picture fuzzy rough weighted geometric mean (PFRWGM) operator, spherical fuzzy rough weighted arithmetic mean (SFRWAM) operator and spherical fuzzy rough weighted geometric mean (SFRWGM) operator are all the special cases of the q-SFRWAM and q-SFRWGM operators. When parameter q = 1, the q-SFRWAM operator reduces the PFRWAM operator, and the q-SFRWGM operator reduces the PFRWGM operator. When parameter q = 2, the q-SFRWAM operator reduces the SFRWAM operator, and the q-SFRWGM operator reduces the SFRWGM operator. Besides, our approach is more flexible, and decision-makers can choose different values of parameter q according to the different risk attitudes. In addition, the basic properties of these newly presented operators have been analyzed in great depth and expounded upon. Additionally, a technique called multi-criteria decision-making (MCDM) has been established, and a detailed example has been supplied to back up the recently introduced work. An evaluation of the offered methodology is established at the article's conclusion. The results of this research show that, compared to the q-spherical fuzzy set, our method is better and more effective.
Modelling exchange rate volatility under jump process and application analysis
Authors: Liu Guifang , Zheng Yuhang , Hu Fan , Du Zhidi
Published: February 2023

Exchange rate is an important part of financial markets. Our analysis finds that the fluctuations of exchange rates have several obvious features, such as spikes, thick tails, fluctuation aggregations and asymmetry. Based on this, we build novel GARCH class model by introducing a jumping process to describe the dynamics of their fluctuations. Our empirical results show that the models with jump factors can better characterize the agglomeration and thick tail characteristics of these return fluctuations than the models without jump factors. In particular, the model with double exponential jumps can fully handle and capture the fluctuation characteristics of the returns. Our findings will be useful for individuals and governments to predict exchange rate fluctuations, provide reference for the effective management of exchange rate risk in China, and further improve the financial risk management mechanism.
Assessment of Quality of the Electronic Education System in the Corona Crisis Period: Applied Study on Al al-Bayt University
Authors: Alsharafat Wafa , Alrashdan Wesam Kurdi , Munther Omar , Yamman Mohammad , Khalid Amaar
Published: February 2023

In response to the coronavirus crisis, higher education institutions have partially or fully transformed into electronic education systems (EESs). This paper presents the results of a student survey conducted at  AL al-Bayt University to assess the quality of the electronic educational system (EES) during the coronavirus pandemic. The study variables addressed by the questionnaire were tangible physical features (TPFs), flexibility (FEES), examination construction and management (ECM); admission, storage, and registration management (ASRM), security and privacy (S&P), learning site content (LSC); and students’ level of satisfaction (LoS). The exploratory study methodology was applied to 324 students at AABU, where the research data were collected using a Google Docs questionnaire and distributed to students. The results highlighted that students were satisfied with the quality of EES implemented by  AABU during the lockdown period in terms of tangible physical features (TPF) and learning site content (LSC) and there was a statistically significant relationship between TPF and LSC. However, some undesirable features were reported, such as a lack of adequate infrastructure for students, which enabled them to interact effectively with their teachers to gain the target of applying EES.  Consequently, AABU needs to implement effective measures to improve and increase the quality and level of satisfaction with EES. Finally, electronic education is a more adapted, smooth, and affordable alternative than traditional face-to-face education.
IoT-Based Pulse Oximetry Design as Early Detection of Covid-19 Symptoms
Authors: Wahyuni Refni , Herianto  , Ikhtiyaruddin  , Yuda Irawan
Published: February 2023

Covid-19 patients experience several symptoms such as shortness of breath, abnormal heart rate, lung function abnormalities that are similar to pneumonia symptoms. These symptom conditions indicate that the saturation of oxygen (O2) levels dissolved in the blood is not normal. To measure oxygen levels in the blood using a medical device, one of which is a Pulse Oximeter. Covid-19 patients in the Sapta Taruna Health Center were 665 patients, of which this patient was counted from January 2022 to April 2022. Based on information obtained from the Sapta Taruna Health Center, the only patients that were counted were those who did the PCR/Swab test, while the people who were suspected infected with Covid-19 there are still many who do not do PCR/Swab tests, this refusal is due to fear because Hoax information is spread in the community such as: PCR/Swab tests are painful, if the PCR/Swab test results are positive, fear of being ostracized, feel healthy and other reasons. other. Patients who have been tested positive for Covid-19 will be given drugs such as fever medicine, antibiotics, anti-virus, Vitamin C, and others according to the level of symptoms they feel, if the symptoms are felt at a moderate, mild or even asymptomatic stage, they will be advised to isolate independently (Isoma) at home, but there is no further monitoring from the Sapta Taruna Health Center, even though patients who are self-isolating at home may experience a decrease in blood oxygen levels drastically, so these patients need medical devices such as pulse oximetry so that patients who are isoma can perform independent checking, henceforth the current pulse oximetry cannot provide remote information related to the condition of oxygen saturation in the patient's blood. Judging from the problems above, the research team made a product, namely Pulse Oximetry based on IoT, this tool is to measure oxygen saturation in the patient's blood and the data from the measurements made by the patient will be automatically sent to the server and can be viewed on the Sapta Taruna Health Center website, so that the Sapta Taruna Health Center can monitoring the condition of the patient in real time without having to meet directly with the patient.
Mapping of Mobile Learning Research Directions and Trends in Scopus-Indexed Journals: A Bibliometric Analysis
Authors: Turmuzi Muhammad , Suharta I Gusti Putu , Astawa I Wayan Puja , Suparta I Nengah
Published: February 2023

Compared to traditional classroom lessons, mobile learning is hailed as a simple, convenient, engaging, innovative, and modern means of learning. Students exhibit more self-discipline and organization during the mobile learning process. Mobile learning is becoming increasingly prevalent in the classroom. It is crucial to develop a shared understanding of the research conducted to comprehend how mobile learning is used. The goal of the study is to summarize the literature on mobile learning based on a bibliometric evaluation of several journal articles published in the Scopus database and to determine fresh ideas and knowledge gaps as a resource for more research. The technique is a bibliometric analysis using the programs VOSviewer, SEforRA, and Publish or Perish. The findings of this analysis show that from 2000 to 2018, the growth of mobile learning research on the Scopus database trended upward and peaked. The expanding trend of research on mobile learning has led to the discovery of numerous themes or keywords that might be used as the basis for further study. In conclusion, the bibliometric analysis provides knowledge and information about the development of mobile learning research for the possibility of a new study
Let's CLIL!
Authors: Ferrero Valerio
Published: February 2023

This chapter articulates its reflection on content and language integrated learning (CLIL) methodology in Italian primary schools from a pedagogical-linguistic perspective, emphasising its educational potential for the personal growth of children. Moving between teacher training and didactic action in the classroom, it will highlight how CLIL is useful in making students citizens capable of acting in the globalal world as people in possession of linguistic, cognitive, metacognitive, and emotional tools for analysing reality. An example of a teaching project using CLIL methodology will be proposed to anchor theoretical reflection to educational practice.
University and Primary Schools Co-Teaching Together
Authors: Manchado-Nieto Cristina , Delicado-Puerto Gemma , Alonso-Díaz Laura
Published: February 2023

Bilingual education is getting great achievements because of the performance of bilingual programs. In Spain, these programs have been developed at the university thanks to the efforts made during the previous decades of their implementation. The autonomous region of Extremadura has been working cooperatively with other institutions since then, and now it is time to look back to recapitulate what has been done and what needs to be done from now on. This chapter aims to gather the main milestones of this process in order to review its internal and external aspects, as well as to reconsider the ways of improving bilingual programs. Final remarks show that bilingual programs have brought benefits, but there are still some aspects that require attention, such as a homogeneous national regulation or minding the methodological qualification of bilingual teachers. These issues need to be addressed in future research for the welfare of bilingual education.
CLIL
Authors: Ting Y. L. Teresa
Published: February 2023

By integrating content and language learning-objectives, one gains a transdisciplinary literacy-focused perspective that brings into focus the thinking skills, literacies, and soft skills that all children need to succeed. This proposition is grounded in two sets of CLIL-materials. For preschoolers, this transdisciplinary literacy-focused perspective transformed must-learn vocabulary and grammar into tasks for cultivating early numeracy, logical thinking, and self-regulatory behaviours. For primary-level learners, this approach recognized the cognitive maturity and reasoning abilities of 8-year-olds: age-appropriate disciplinary concepts regarding natural history were presented through materials using age-matched academic language, thus providing children whole complex discourses for thinking whole complex thoughts. To help readers incorporate such a perspective into their own practice, a workshop format presents some cognitive-neuroscience principles guiding the development of these materials alongside specific design considerations, implementation processes, and classroom observations.
Example of a CLIL Teaching-Learning Sequence About Geology and Evolution for Pre-Service Teachers
Authors: Pla-Pueyo Sila , González-García Francisco , Ramos-García Ana María , Torres-Zúñiga Laura
Published: February 2023

The present chapter describes in detail a teaching-learning sequence using the CLIL approach to teach contents related to sedimentary rocks, fossils, and evolution to pre-service primary education teachers. The sequence was designed and implemented during two consecutive semesters of the academic year 2021-2022. The target students belong to the bilingual strand of the courses ‘Didactics of Experimental Sciences' I and II, dealing with physics, chemistry, geology, and astronomy contents (course I) and life sciences contents (course II). The courses are taught mainly in Spanish, but this particular sequence was delivered, produced, and assessed in English. Students' performance was assessed by means of self-evaluation, peer-evaluation, as well as immediate or delayed feedback from the lecturer.
Opportunities and Challenges in Educational Chatbots
Authors: Hammad Rawad , Bahja Mohammed
Published: February 2023

The rapid technological developments have revolutionised approaches toward learning. The adoption of eLearning technologies such as chatbots has been increasing in the past few years, as there are various opportunities that can be identified to integrate educational chatbots with online learning process. For example, chatbots in education can provide various services such as personal tutoring, personal support, assessment and evaluation, etc. Iissues in remote learning—such as real-time assistance, feedback, and support—can be addressed by deploying educational chatbots. Yet, there are various challenges associated with chatbot technologies in education, e.g., novelty effect, cognitive load, the readiness of students and teachers, etc. This study reviews the various opportunities and challenges associated with educational chatbots in learning. These findings would help future researchers and designers to identify the core functionality and design aspects of educational chatbots, and also aids future research by the recommendations of research propositions.
Perceived level of stress in patients with acute coronary syndrome in Sri Lanka: associations and short-term outcomes
Authors: Matthias A. T. , De Silva D. K. N. , Indrakumar J. , Gunatilake S. B.
Published: February 2023

Background: Chronic stress is a known risk factor for cardiovascular disease. This study sought to determine the association between the ‘perceived level of stress’ in patients with acute coronary syndrome (ACS) and its short-term outcome. This is the first study done on the perceived level of stress in patients with ACS in Sri Lanka.
Methods: A total of 313 ACS patients from the Professorial Unit of the Colombo South Teaching Hospital completed the Perceived Stress Scale-10. The scale assesses the stress perceived by the patient based on ten questions. The sum of scores ranges from 0-40. High stress was defined as scores of 20 or above.
Results: High-stress levels were found in 238 (76%) patients and low stress in 75 (24%). There was no difference in the level of stress perceived by males and females (p=.5). Stress levels did not change the nature of the presenting complaint: typical chest pain versus another complaint (p=.09). Patients with high-stress levels presented early (within 12 hours) to the hospital (p<.05). There was no difference in the stress levels of patients presenting with different types of ACS: ST-Elevation Myocardial Infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), or unstable angina (UA) (p=.147).
Conclusions: High-stress levels were seen in most patients with ACS and steps need to be taken to reduce stress. The stress levels did not influence the severity or the type of ACS. Patients with high-stress levels were likely to present early to the hospital.
SLCIM Picture Quiz
Authors: Singhapathirana Suranga , Karunarathna Shashi , Hettiarachchi N. Madhuwanthi
Published: February 2023

No abstract available
Docetaxel- induced organising pneumonia in a patient with advanced breast cancer: case report
Authors: Liyanage L. , Perera C. C. , Ranaweera N.
Published: February 2023

Pulmonary toxicity is a rare complication of taxanes, which are used in chemotherapy regimes in advanced breast carcinoma. We report a case of a 47- year- old woman with locally advanced breast carcinoma who developed organizing pneumonia following docetaxel based neoadjuvant chemotherapy. Following exclusion of infective causes, she was treated with prednisolone, resulting in a remarkable clinical and radiological resolution on high resolution computed tomography. Early identification and judicious steroid therapy can provide excellent outcomes in patients with docetaxel induced interstitial lung disease despite reported high morbidity and mortality.
Inflammatory aorta in Giant Cell Arteritis disease: a case study of 5 patients
Authors: Chabchoub I. , Snoussi M. , Frikha F. , Dammak C. , Marzouk S. , Bahloul Z.
Published: February 2023

Introduction: Aortitis defined as the inflammation of the aortic wall can be due to various diseases including giant cell arteritis (GCA). Aortic involvement in GCA, reported since 1940, is rarely described. The main objective of this study was to analyse the epidemiological, clinical, radiological and evolutionary characteristics of patients with inflammatory aortitis in a cohort of patients diagnosed with GCA. We conducted a review of the literature to study the clinical and paraclinical aspects of this entity and to describe a diagnostic and therapeutic approach to inflammatory aortitis in GCA.
Methods: This is a retrospective descriptive study of 109 patients with giant cell arteritis fulfilling the diagnostic criteria established by the American College of Rheumatology (ACR), conducted over a period of 25 years (1996-2020) in the internal medicine department in Hedi Chaker University Hospital, Sfax, Tunisia. The diagnosis of inflammatory aortitis was made on the basis of aortic tomography.
Results: Five patients out of 109 (4.5%) had an aorta authenticated by aortic tomography. They were 2 men and 3 women with an average age of 64.2 years. The aortitis was revealed by non-specific systemic signs in all cases, namely fever, a biological inflammatory syndrome and abdominal pain in 1 patient. Clinical examination revealed a vascular murmur in one patient. A biological inflammatory syndrome (BIS) was present in all cases. Aortic involvement was discovered at the time of diagnosis of GCA in all cases. It was detected by thoracoabdominal aortic tomography in all cases and aortic MRI in one case. It involved the thoracoabdominal aorta in 4 cases and the abdominal aorta in one case. Treatment was based on high-dose corticosteroid therapy combined with an antiplatelet agent in the five patients. The evolution was marked by the achievement of apyrexia and regression of the BIS in all cases. A radiological check-up was carried out in only one patient, initially showing a stable appearance and then partial regression of the thoracoabdominal aorta at 6 and 18 months respectively.
Conclusion: Inflammatory involvement of the aorta in giant cell arteritis. remains a serious and potentially life-threatening complication in the case of aneurysm rupture or aortic dissection. Initially, the diagnosis may be difficult due to the non-specific clinical presentation. Systematic screening for this condition by aortic tomography is increasingly recommended. Prompt intensive drug treatment based mainly on corticosteroids may reduce short and long-term morbidity.
Gut microbiota modulate susceptibility to bleomycin-induced lung injury.
Authors: Yoon Young me , Barrón Gabe M , Hrusch Cara L , Fei Na , Leone Vanessa A , Sperling Anne I
Published: February 2023

Acute lung injury (ALI) resulting in acute respiratory distress syndrome (ARDS) affects almost 200,000 people in the US each year, leading to 75,000 deaths. Airway instillation of bleomycin (BLM) in mice is a widely used, yet challenging model for ALI due to high variability. We have observed that B6 mice from two SPF facilities at our University exhibit significantly different mortality and weight loss in response to BLM. To test whether the facility-dependent response to BLM can be transferred by the microbiome, we conventionalized germ-free (GF) B6 littermates in each facility and challenged with BLM. Conventionalized GF mice recapitulated the respective donors’ response to BLM. Further, fecal microbiota transfer from the facility where the mice had worse mortality into the mice in the facility with more survival rendered recipient mice more susceptible to BLM compared to controls, indicating that the differential gut microbiome between two facilities were sufficient to modulate BLM response. To identify microorganisms that drive the phenotype, we compared gut microbial community memberships by 16S rRNA and metagenomics sequencing. Interestingly, BLM highly susceptible mice had greater alpha diversity and harbored specific species of Bacteroides, Prevotella, and Helicobacter genera. Flow cytometry of the lung immune cell landscape at baseline revealed comparable composition and phenotype of adaptive immune cells regardless of facility. However, lung NK cells were significantly increased BLM highly susceptible mice. Thus, we demonstrate that distinct gut microbiota communities modulate death and weight loss in response to BLM-induced lung injury, implicating host-commensal interactions in regulating ALI outcomes.
Consequences of maternal breast milk antibodies on neonatal mucosal immunity and intestinal microbe composition
Authors: Wang Bingjie , Koch Meghan
Published: February 2023

Breastfeeding is associated with decreased risk of acquiring inflammatory bowel disorders later in life. As breastfeeding is not possible for all mothers and children, having a mechanistic understanding of this process can lead to the development of early-life interventions to foster beneficial host-microbiota relationships, particularly in neonates who are not breastfed.

We have shown that mice lacking breast milk antibodies (bmAbs) exhibit dysregulated intestinal homeostasis. These mice harbor increased numbers of live bacteria in the mesenteric lymph nodes and exhibit perturbations in mucosal immunity, including elevated T follicular helper (Tfh) cell and germinal center (GC) B cell responses in the gut-associated lymphoid tissues. Antibodies are key regulators of host-microbiome interactions, and T-dependent (TD) GC derived B cells can persist up to the lifetime of the host. We hypothesize that the TD antibodies generated by the neonate in the absence of bmAbs target resident gut bacteria and lead to long-term alterations in the composition of the microbiota.

We performed RT-PCR of the bacterial 16s rRNA gene to quantify the amount of wall-associated microbes in the small and large intestine of mice that received or did not receive bmAbs. To probe the effects of Tfh cells and TD antibodies, we treated half of the mice from each group with anti-ICOS ligand antibody, which blocks Tfh and GC cell formation. We found no significant difference in bacterial burden across all four groups in the small or large intestine. These data suggest that Tfh-cell dependent, bmAb-dependent antibodies do not alter the abundance of wall-associated microbes. Studies are ongoing to determine if bmAbs affect intestinal microbe composition later in life.
Tissue localization and virus specificity shape the maintenance and function of human virus-specific memory T cells recognizing HCMV and influenza A
Authors: Poon Maya M.L. , Byington Eve , Meng Wenzhao , Dogra Pranay , Lam Nora , Szabo Peter Anthony , Ural Basak , Grifoni Alba , Weiskopf Daniela , Kubota Masaru , Matsumoto Rei , Sette Alessandro , Shen Yufeng , Prak Eline T Luning , Farber Donna L
Published: February 2023

Generation and maintenance of memory T cells within tissue sites of infection is critical for long-term antiviral protection. Current knowledge of human antiviral responses is largely derived from studies sampling peripheral blood. Yet, little is known about human tissue-localized antiviral immunity. Utilizing our human donor tissue resource established in collaboration with LiveOnNY, we investigated how tissue, virus, and age shape T cell maintenance across diverse tissues and their function when presented with antigens derived from human cytomegalovirus (HCMV) or influenza A virus (flu). Using flow cytometry, we show that virus-specific CD8 T cells are maintained in diverse tissues with subset differentiation and distribution shaped by virus specificity and age. Compared to T cells recognizing HCMV, flu-specific T cells display higher levels of residency markers—CD69 and CD103—particularly in adult compared to pediatric donors. In contrast, HCMV-specific T cells are maintained in greater abundance as terminally-differentiated effector T cells. Sequencing of the T cell receptor CDR3b chain reveals that, while both HCMV- and flu-specific T cells demonstrate clonal overlap across multiple tissues, HCMV-specific T cells display greater clonality and less diversity. When presented with viral antigens, HCMV- and flu-specific T cells are polyfunctional. Additionally, single-cell transcriptome profiling reveals tissue localization is the primary determinant of antigen-driven responses. Together, these studies demonstrate the dynamics of T cell differentiation and maintenance throughout the human body, which is primarily driven by virus specificity, and the role of tissue localization in shaping antiviral response.
Identifying mechanisms that enhance the longevity of tissue-resident memory CD8+ T cells in the lung
Authors: Lobby Jenna L , Uddback Ida Elin Maria , Scharer Christopher D. , Mi Tian , Boss Jeremy M. , Thomsen Allan R , Christensen Jan Pravsgaard , Kohlmeier Jacob E
Published: February 2023

Lung tissue-resident memory CD8+ T cells (TRM) are crucial mediators of cellular immunity against influenza viruses, but the number of these cells in the lung tissue gradually declines in the months following influenza infection. Recently, we showed that intranasal immunization with a replication-deficient adenovirus that expresses the nucleoprotein from influenza A virus (AdNP) results in long-term maintenance of lung CD8+ TRM for up to 1-year post-immunization. However, the mechanism(s) that promote this enhanced longevity of FluNP-specific CD8+ lung TRM remain unknown. Using a combination of mouse infection models, flow cytometry, and RNA-sequencing, we compared CD8+ T cells from the airways, lungs, and spleen of AdNP-immunized or influenza x31-infected mice. We found that CD8+ TRM in the lungs of AdNP-immunized mice show increased homeostatic turnover and hallmarks of persistent antigen stimulation in the lung. However, RNA-sequencing analysis comparing lung CD8+ TRM from AdNP-immunized and x31-infected mice at 1-month and 1-year post-immunization showed only minor variations that did not fully explain the differences in lung TRM persistence. Lineage tracing experiments using a Cre recombinase-expressing Adenovirus (AdCre) identified alveolar macrophages as the primary cell type harboring persistent antigen in the lung. Together, these results define one mechanism for enhancing the durability of lung TRM, which is an important consideration for the design of future cell-mediated influenza vaccines