bluuebunny/crossref_metadata_2025 huggingface dataset:
PERAN NOTARIS DALAM PENDIRIAN PERSEROAN TERBATAS PASCA UNDANG-UNDANG NOMOR 11 TAHUN 2020 TENTANG CIPTA KERJA
Authors: Putri Bernanti Aryajaya , Mekka Putra Mohammad Fajri
Published: July 2022

ABSTRAK Berlakunya Undang-undang Nomor 11 Tahun 2020 tentang Cipta Kerja membawa perubahan dalam hukum perseroan terbatas di Indonesia, yakni Undang-undang Nomor 40 tahun 2007. Perseroan terbatas kini terbagi menjadi dua yaitu perseroan persekutuan modal dan perseroan perorangan. Sebelum berlakunya Undang-undang Cipta Kerja, diatur bahwa pendirian perseroan harus dengan akta notaris. Notaris merupakan pejabat umum yang berwenang untuk membuat akta otentik, salah satunya adalah akta pendirian perseroan sesuai yang disyaratkan dalam Undang-undang Perseroan Terbatas. Merujuk pada Pasal 153A ayat (1) dan (2) Undang-undang Perseroan Terbatas yang merupakan pasal baru setelah berlakunya Undang-undang Cipta Kerja, diatur bahwa perseroan yang memenuhi kriteria Usaha Mikro dan Kecil dapat didirikan oleh 1 (satu) orang berdasarkan surat pernyataan pendirian yang dibuat dalam Bahasa Indonesia. Dengan diubahnya ketentuan tersebut, pendirian perseroan tidak lagi disyaratkan untuk menggunakan akta notaris bagi perseroan perorangan yang masuk ke dalam kategori Usaha Mikro dan Kecil. Oleh karena itu, penelitian ini bertujuan untuk menganalisis lebih lanjut tentang peran notaris dalam pendirian perseroan terbatas pasca berlakunya Undang-undang Nomor 11 Tahun 2020 tentang Cipta Kerja. Kata kunci: Perseroan Terbatas, Notaris, Perseroan Perorangan, Usaha Mikro dan Kecil ABSTRACT The enactment of Law Number 11 Year 2020 on Job Creation brought changes to the law of limited liability companies in Indonesia, namely Law Number 40 Year 2007. Limited liability company is now divided into two, which are capital partnership and a sole proprietorship company. Prior to the enactment of the Job Creation Act, it was regulated that the establishment of a company must be done with a notarial deed. A notary is a public official who is authorized to make an authentic deed, one of which is the deed of establishment of the company as required by the Limited Liability Company Law. Referring to Article 153A paragraphs (1) and (2) of the Limited Liability Company Law which is a new provision after the enactment of Job Creation Act, it is regulated that a company that meets the criteria for Micro and Small Business can be established by 1 (one) person based on a statement of establishment. With the amendment of these provisions, the establishment of a company is no longer required to use a notarial deed for companies that fall into the category of Micro and Small Enterprises. Therefore, this research aims to further analyze the role of a notary in the establishment of a limited liability company after the enactment of the Job Creation Act. Keywords: Limited Liability Company, Notary Public, Sole Proprietorship, Micro and Small Enterprises
EKSISTENSI DAN PERAN LEMBAGA MAJELIS KEHORMATAN NOTARIS DALAM MEMBERIKAN PERLINDUNGAN HUKUM BAGI NOTARIS (STUDI KASUS PUTUSAN MAHKAMAH AGUNG NO. 20 PK/PID/2020)
Authors: Athira Amira Budi , Hoesin Siti Hajati
Published: July 2022

AbstractA Notary, is one of the professions in the law field, that truly deserves legal protection in carrying out their duties and functions as public officials that are authorized to make authentic deeds. Therefore, in the even of a notary is suspected of committing a violation of criminal law or an unlawful act, the role of the Notary Honorary Council is urgently needed to participate in providing legal protection for notaries. The duties and functions of the Notary Honorary Council itself is to give approval or refusal for the purposes of investigation in the judicial process. This also plays an important role because it aims to maintain the authority of a notary, so that there is no legal process that goes wrong or inappropriate even arbitrarily by criminalizing the act of a notary as a criminal offense, not necessarily an error in criminal law. However, in practice, this function still has several obstacles. This can be seen in the Court Verdict No. 20/PK/Pid/2020, where a notary is criminally charged, even though it is not classified as a criminal realm, but in the administrative realm. Keywords: Notary Honorary Council, criminal law, and legal protection. AbstrakNotaris, merupakan salah satu profesi di bidang hukum yang sudah sepatutnya mendapatkan perlindungan hukum dalam menjalankan tugas dan fungsinya sebagai pejabat publik yang diberi wewenang untuk membuat akta autentik. Oleh karena itu, dalam hal seorang notaris diduga melalukan suatu pelanggaran hukum pidana atau perbuatan melawan hukum, peran Majelis Kehormatan Notaris sangat dibutuhkan untuk turut memberikan perlindungan hukum bagi notaris. Tugas dan fungsi dari Majelis Kehormatan Notaris sendiri, adalah memberikan persetujuan atau penolakan untuk kepentingan penyidikan dalam proses peradilan. Hal ini juga memegang peranan penting karena bertujuan untuk menjaga wibawa notaris, agar tidak terjadi proses hukum yang salah atau tidak tepat bahkan sewenang-wenang dengan mengkriminalisasi perbuatan notaris sebagai tindak pidana, yang belum tentu merupakan kesalahan dalam hukum pidana. Namun, dalam pelaksanaannya, fungsi ini masih memiliki beberapa kendala. Hal ini dapat dilihat dalam Putusan Mahkamah Agung No. 20/PK/Pid/2020, dimana seorang notaris dijerat hukuman pidana, meskipun sebenarnya tidak tergolong ke dalam ranah pidana, tetapi dalam ranah administrasi. Kata Kunci: Majelis Kehormatan Notaris, hukum pidana, dan perlindungan hukum.
AKIBAT HUKUM AKTA JUAL BELI YANG MELANGGAR PASAL 40 AYAT 2 HURUF E UNDANG-UNDANG NOMOR 2 TAHUN 2014 (Studi Kasus Putusan Mahkamah Agung Nomor 156 K/PDT/2020)
Authors: Simanjuntak Christin Novalia , Hoesin Siti Hajati
Published: July 2022

AbstractNotaries as public officials have the function to create perfect evidence, act carefully and do their work in all honesty to maintain the dignity of a notary. In the making of an authentic deed, witnesses who participate in the making of the authentic deed are required. Witnesses and its qualification, or conditions that must be met by the witnesses have been determined by the law that can be found in Article 40 of Law Number 2 of 2014. The issue raised in this case is the Supreme Court Decision Case Number 156 K/PDT/2020. In this case, there are two deeds of sale and purchase which have the siblings of the seller stated as the witnesses . Therefore, this study will discuss what legal consequences arise from these actions and the responsibility of the notary as the party who made the deed of sale and purchase of the land. Keywords: Witness, Sale and Purchase, Deed AbstrakNotaris sebagai pejabat umum memiliki fungsi untuk menciptakan alat pembuktian yang sempurna, bertindak hati-hati serta jujur dalam bekerja dan menjaga martabat Notaris. Dalam pembuatan akta otentik, diperlukan saksi-saksi yang ikut serta dalam pembuatan akta otentik tersebut. Saksi sendiri diatur dalam Pasal 40 Undang-undang Nomor 2 Tahun 2014 Tentang Jabatan Notaris, adapun syarat yang harus dipenuhi oleh saksi telah ditentukan oleh Undang-undang. Permasalahan yang diangkat dalam kasus ini adalah mengenai Kasus Putusan Mahkamah Agung Nomor 156 K/PDT/2020. Pada kasus ini, dua orang kakak beradik menjadi saksi pada akta jual beli tanah yang dibuat oleh satu sama lain. Oleh karena itu, Penelitian ini akan membahas akibat hukum apa yang timbul dari tindakan tersebut serta pertanggungjawaban notaris selaku pihak yang membuat akta jual beli tanah tersebut. Kata Kunci: Saksi, Jual Beli, Akta
Urticaria in Pregnancy and Lactation
Authors: Kocatürk Emek , Podder Indrashis , Zenclussen Ana C. , Kasperska Zajac Alicja , Elieh-Ali-Komi Daniel , Church Martin K. , Maurer Marcus
Published: July 2022

Chronic urticaria (CU) is a mast cell-driven chronic inflammatory disease with a female predominance. Since CU affects mostly females in reproductive age, pregnancy is an important aspect to consider in the context of this disease. Sex hormones affect mast cell (MC) biology, and the hormonal changes that come with pregnancy can modulate the course of chronic inflammatory conditions, and they often do. Also, pregnancy-associated changes in the immune system, including local adaptation of innate and adaptive immune responses and skewing of adaptive immunity toward a Th2/Treg profile have been linked to changes in the course of inflammatory diseases. As of now, little is known about the effects of pregnancy on CU and the outcomes of pregnancy in CU patients. Also, there are no real-life studies to show the safety of urticaria medications during pregnancy. The recent PREG-CU study provided the first insights on this and showed that CU improves during pregnancy in half of the patients, whereas it worsens in one-third; and two of five CU patients experience flare-ups of their CU during pregnancy. The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for urticaria recommends adopting the same management strategy in pregnant and lactating CU patients; starting treatment with standard doses of second-generation (non-sedative) H1 antihistamines, to increase the dose up to 4-folds in case of no response, and to add omalizumab in antihistamine-refractory patients; but also emphasizes the lack of evidence-based information on the safety and efficacy of urticaria treatments during pregnancy. The PREG-CU study assessed treatments and their outcomes during pregnancy. Here, we review the reported effects of sex hormones and pregnancy-specific immunological changes on urticaria, we discuss the impact of pregnancy on urticaria, and we provide information and guidance on the management of urticaria during pregnancy and lactation.
Non-Lethal Blasts can Generate Cavitation in Cerebrospinal Fluid While Severe Helmeted Impacts Cannot: A Novel Mechanism for Blast Brain Injury
Authors: Yu Xiancheng , Nguyen Thuy-Tien , Wu Tianchi , Ghajari Mazdak
Published: July 2022

Cerebrospinal fluid (CSF) cavitation is a likely physical mechanism for producing traumatic brain injury (TBI) under mechanical loading. In this study, we investigated CSF cavitation under blasts and helmeted impacts which represented loadings in battlefield and road traffic/sports collisions. We first predicted the human head response under the blasts and impacts using computational modelling and found that the blasts can produce much lower negative pressure at the contrecoup CSF region than the impacts. Further analysis showed that the pressure waves transmitting through the skull and soft tissue are responsible for producing the negative pressure at the contrecoup region. Based on this mechanism, we hypothesised that blast, and not impact, can produce CSF cavitation. To test this hypothesis, we developed a one-dimensional simplified surrogate model of the head and exposed it to both blasts and impacts. The test results confirmed the hypothesis and computational modelling of the tests validated the proposed mechanism. These findings have important implications for prevention and diagnosis of blast TBI.
Development and Application of a Platform for Multidimensional Urban Earthquake Impact Simulation
Authors: Hsu Chih-Hao , Ke Siao-Syun , Wu Tzu-Hsiu
Published: July 2022

Earthquakes can be devastating to cities. Therefore, accurate and efficient simulation of the potential seismic damage to buildings has become an indispensable part of worldwide efforts to mitigate earthquake hazards. Precise simulation results can highlight potential seismic damage and serve as a reference in urban development and for planning post-earthquake rescue operations. In urban areas, simulation of the structural dynamic response during an earthquake is key for planning an appropriate emergency response. Multidimensional visualization of the effects of earthquakes is a popular technique in current earthquake simulation research. In the present study, a dynamic multidimensional simulation method was developed for analyzing the impact of an earthquake on buildings. This method involved conducting three-dimensional (3D) dynamic analysis of data from a seismic capacity database. Polygonal models and seismic capacity data were used in a high-performance computing process to calculate the seismic response of each building in an urban environment. On the basis of the calculations, a platform was developed for multidimensional urban earthquake impact simulation (MDUES). The developed MDUES platform enables analysis of the impact of long-period earthquakes, simulation of the 3D seismic responses of buildings, and visualization of the disaster risk and earthquake impact in a specified area. In summary, simulation of structural seismic responses in an urban setting necessitates a careful examination of the characteristics of ground and building motion, and the results of this simulation can provide a crucial reference for city planning, post-earthquake rescue operations, and seismic damage assessments.
The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine
Authors: Xiao Zhuoyu , Liu Sun , Li Zengguang , Cui Jinru , Wang Hailan , Wang Zihan , Ren Qihuan , Xia Laixin , Wang Zhijian , Li Yuan
Published: July 2022

The microbiome exerts profound effects on fetal development and health, yet the mechanisms underlying remain elusive. N6-methyladenosine (m6A) plays important roles in developmental regulation. Although it has been shown that the microbiome affects the mRNA m6A modification of the host, it remains unclear whether the maternal microbiome affects m6A epitranscriptome of the fetus so as to impact fetal development. Here, we found that loss of the maternal microbiome altered the expression of m6A writers and erasers, as well as the m6A methylome of the mouse fetal brain and intestine on embryonic day 18. From the m6A profiles, we identified 2,655 and 2,252 m6A modifications regulated by the maternal microbiome in the fetal brain and intestine, respectively, and we demonstrated that these m6A-modified genes were enriched in the neuro/intestinal developmental pathways, such as the Wnt signaling pathway. Finally, we verified that antibiotic treatment mostly recapitulated changes in m6A, and we further showed that the loss of heterozygosity of Mettl3 rescued m6A levels and the expression changes of some developmental genes in the fetal intestine that resulted from antibiotic treatment. Collectively, our data revealed that the maternal microbiome programs the m6A epitranscriptome of the mouse fetal brain and intestine.
Single-Cell RNA Sequencing for Analyzing the Intestinal Tract in Healthy and Diseased Individuals
Authors: Yan Hua , Ye Yumeng , Zhao HanZheng , Zuo Hongyan , Li Yang
Published: July 2022

The intestinal tract is composed of different cell lineages with distinct functions and gene expression profiles, providing uptake of nutrients and protection against insults to the gut lumen. Changes in or damage to the cellulosity or local environment of the intestinal tract can cause various diseases. Single-cell RNA sequencing (scRNA-seq) is a powerful tool for profiling and analyzing individual cell data, making it possible to resolve rare and intermediate cell states that are hardly observed at the bulk level. In this review, we discuss the application of intestinal tract scRNA-seq in identifying novel cell subtypes and states, targets, and explaining the molecular mechanisms involved in intestinal diseases. Finally, we provide future perspectives on using single-cell techniques to discover molecular and cellular targets and biomarkers as a new approach for developing novel therapeutics for intestinal diseases.
A Low-Cost Paper-Based Device for the Colorimetric Quantification of Bilirubin in Serum Using Smartphone Technology
Authors: AuYoung Brittany , Gutha Ravichandran Akshay , Patel Divykumar , Dave Nisarg , Shah Achal , Wronko-Stevens Brianna , Bettencourt Franklin , Rajan Reshma , Menon Nidhi
Published: July 2022

Total bilirubin values have been used as a potential marker to pre-screen and diagnose various liver-based diseases such as jaundice, bile obstruction, liver cancer, etc. A device known as KromaHealth Kit, composed of paper and an acrylic backbone, is developed to quantify total bilirubin in human serum using image processing and machine learning technology. The biochemical assays are deposited on absorbent paper pads that act as reaction zones when serum is added. A dedicated smartphone app captures images of the colorimetric changes on the pad and converts them into quantitative values of bilirubin. The range of bilirubin concentration that can be quantified using the device ranges from 0.5 mg/dl to 7.0 mg/dl. The precision, limit of detection, interference analysis, linearity, stability, and comparison with a predicate are studied in this paper in accordance with clinical and laboratory standards institute. The results indicate that the KromaHealth Kit can be used as an inexpensive alternative to conventional bilirubin testing in clinical settings. With its level of precision, ease-of-use, long shelf-life, and short turnaround time, it will prove to be invaluable in limited-resource settings.
Interface-Coupling of NiFe-LDH on Exfoliated Black Phosphorus for the High-Performance Electrocatalytic Oxygen Evolution Reaction
Authors: Fan Jinchen , Qin Xi , Jiang Wendan , Lu Xiaolei , Song Xueling , Guo Wenyao , Zhu Sheng
Published: July 2022

Electrochemical oxygen evolution reaction (OER) always plays an important role in many electrochemical energy storage and conversion systems. Owing to the slow kinetics mainly brought from multiple proton-coupled electron transfer steps, the design and exploit low-cost, highly active, durable OER electrocatalysts are of significant importance. Although the black phosphorus (BP) shows good electrocatalytic OER performance, it still faces the problems of poor intrinsic activity and low stability due to its instability under ambient conditions. The NiFe-LDH was assembled onto the surfaces of exfoliated BP (EBP) nanoflakes to realize the interfacial coupling between them, achieving an effective improvement in electrocatalytic activity and stability. Benefitting from the interfacial P-O bonding, the NiFe-LDH@EBP hybrid shows high OER activity with a low overpotential of ∼240 mV@10 mA cm−2 toward OER under alkaline conditions, as well as the good stability. Density functional theory (DFT) calculations proved that the interface-coupling of NiFe-LDH on BP promotes charge transfer kinetics and balances the adsorption/desorption of reaction intermediates, ultimately imparting excellent OER electrocatalytic activity.
Strain Effects on the Electronic and Optical Properties of Blue Phosphorene
Authors: Zhang Lin , Cui Zhen
Published: July 2022

Monolayer blue phosphorene (BlueP) systems were investigated under biaxial strain range from −10% to +10%. All these systems exhibit excellent stability, accompanying changes in the electronic and optical properties. BlueP becomes metallic at −10% strain and transforms into a direct semiconductor at 10% strain while maintaining indirect semiconductor behaviors at −8% to +8% strain. The bandgap of BlueP decreases linearly with strain, and tensile strain exhibits a more moderate bandgap modulation than compressive strain. The real part of the dielectric function of BlueP is enhanced under compressive strain, while the optical absorption in the visible and the infrared light regions increases significantly under tensile strain. The maximum absorption coefficient of 0.52 ×105/cm occurs at 530 nm with the 10% strain. Our analysis indicates that the semiconductor–metal transition and the indirect–direct bandgap transition are the competition results of the energy states near the Fermi level under a massive strain. The potent compressive strain leads the py orbitals of the conduction band to move downward and pass through the Fermi level at the K point. The robust tensile strain guides the energy states at the Γ point to approach the Fermi level and become the band edges. Our results suggest that the energy storage capacity of BlueP can be significantly improved by compressive strain, while the visible light photocatalytic performance is enhanced by tensile strains of less than 8%. Our works provide a reference for the practical applications of BlueP in photocatalyst, photovoltaic cells, and electronic devices.
Interspecies Isobaric Labeling-Based Quantitative Proteomics Reveals Protein Changes in the Ovary of Aedes aegypti Coinfected With ZIKV and Wolbachia
Authors: Ramos Luís Felipe Costa , Martins Michele , Murillo Jimmy Rodriguez , Domont Gilberto Barbosa , de Oliveira Danielle Maria Perpétua , Nogueira Fábio César Sousa , Maciel-de-Freitas Rafael , Junqueira Magno
Published: July 2022

Zika is a vector-borne disease caused by an arbovirus (ZIKV) and overwhelmingly transmitted by Ae. aegypti. This disease is linked to adverse fetal outcomes, mostly microcephaly in newborns, and other clinical aspects such as acute febrile illness and neurologic complications, for example, Guillain-Barré syndrome. One of the most promising strategies to mitigate arbovirus transmission involves releasing Ae. aegypti mosquitoes carrying the maternally inherited endosymbiont bacteria Wolbachia pipientis. The presence of Wolbachia is associated with a reduced susceptibility to arboviruses and a fitness cost in mosquito life-history traits such as fecundity and fertility. However, the mechanisms by which Wolbachia influences metabolic pathways leading to differences in egg production remains poorly known. To investigate the impact of coinfections on the reproductive tract of the mosquito, we applied an isobaric labeling-based quantitative proteomic strategy to investigate the influence of Wolbachia wMel and ZIKV infection in Ae. aegypti ovaries. To the best of our knowledge, this is the most complete proteome of Ae. aegypti ovaries reported so far, with a total of 3913 proteins identified, were also able to quantify 1044 Wolbachia proteins in complex sample tissue of Ae. aegypti ovary. Furthermore, from a total of 480 mosquito proteins modulated in our study, we discuss proteins and pathways altered in Ae. aegypti during ZIKV infections, Wolbachia infections, coinfection Wolbachia/ZIKV, and compared with no infection, focusing on immune and reproductive aspects of Ae. aegypti. The modified aspects mainly were related to the immune priming enhancement by Wolbachia presence and the modulation of the Juvenile Hormone pathway caused by both microorganism’s infection.
Case Report: Anomalous Origin of the Right Coronary Artery From the Left Sinus of Valsalva With Aortic Dissection: New Myocardial Ischemia Mechanism
Authors: Xie Zhongshang , Zou Junlin , Zhu Hong , Bu Haisong
Published: July 2022

The aortic anomaly of the right coronary artery (AAORCA) originating from the left aortic sinus (LCS) is a rare malformation that may result in sudden cardiac death (SCD), which may be due to the dilated aorta-pulmonary artery affecting the blood supply of the coronary artery. However, there are still some disputes about the treatment of the AAORCA. Herein, we present a rare case of AAORCA from the LCS with aortic dissection (AD). Considering the risk of dissection rupture and SCD, an emergency surgery of aortic replacement and coronary anomaly correction was performed successfully for the patient. This report illustrated that AAORCA complicated with acute AD (AAD) is lethal and may promote the occurrence of coronary ischemia or sudden death by a new “double-kill” mechanism that myocardial ischemia was based on the extent of a fixed and a dynamic component like slit-like ostium, proximal narrowing, acute take-off angle and intramural course with the elliptic vessel shape. There is no doubt that surgery is the best treatment option for the AAORCA with AAD.
Comparison of the Efficacy of ECMO With or Without IABP in Patients With Cardiogenic Shock: A Meta-Analysis
Authors: Zeng Ping , Yang Chaojun , Chen Jing , Fan Zhixing , Cai Wanyin , Huang Yifan , Xiang Zujin , Yang Jun , Zhang Jing , Yang Jian
Published: July 2022

Objective

Studies on extracorporeal membrane oxygenation (ECMO) with and without an intra-aortic balloon pump (IABP) for cardiogenic shock (CS) have been published, but there have been no meta-analyses that compare the efficacy of these two cardiac support methods. This meta-analysis evaluated the outcomes of these two different treatment measures.

Methods

The PubMed, Embase, Cochrane Library, Web of Science, and Clinical Trials databases were searched until March 2022. Studies that were related to ECMO with or without IABP in patients with CS were screened. Quality assessments were evaluated with the methodological index for nonrandomized studies (MINORS). The primary outcome was in-hospital survival, while the secondary outcomes included duration of ECMO, duration of ICU stay, infection/sepsis, and bleeding. Revman 5.3 and STATA software were used for this meta-analysis.

Results

In total, nine manuscripts with 2,573 patients were included in the systematic review. CS patients who received ECMO in combination with IABP had significantly improved in-hospital survival compared with ECMO alone (OR = 1.58, 95% CI = 1.26–1.98, P < 0.0001). However, there were no significant differences in the duration of ECMO (MD = 0.36, 95% CI = −0.12–0.84, P = 0.14), duration of ICU stay (MD = −1.95, 95% CI = −4.05–0.15, P = 0.07), incidence of infection/sepsis (OR = 1.0, 95% CI = 0.58–1.72, P = 1.0), or bleeding (OR = 1.28, 95% CI = 0.48–3.45, P = 0.62) between the two groups of patients with CS.

Conclusion

ECMO combined with IABP can improve in-hospital survival more effectively than ECMO alone in patients with CS.
Voice Analysis for Neurological Disorder Recognition–A Systematic Review and Perspective on Emerging Trends
Authors: Hecker Pascal , Steckhan Nico , Eyben Florian , Schuller Björn W. , Arnrich Bert
Published: July 2022

Quantifying neurological disorders from voice is a rapidly growing field of research and holds promise for unobtrusive and large-scale disorder monitoring. The data recording setup and data analysis pipelines are both crucial aspects to effectively obtain relevant information from participants. Therefore, we performed a systematic review to provide a high-level overview of practices across various neurological disorders and highlight emerging trends. PRISMA-based literature searches were conducted through PubMed, Web of Science, and IEEE Xplore to identify publications in which original (i.e., newly recorded) datasets were collected. Disorders of interest were psychiatric as well as neurodegenerative disorders, such as bipolar disorder, depression, and stress, as well as amyotrophic lateral sclerosis amyotrophic lateral sclerosis, Alzheimer's, and Parkinson's disease, and speech impairments (aphasia, dysarthria, and dysphonia). Of the 43 retrieved studies, Parkinson's disease is represented most prominently with 19 discovered datasets. Free speech and read speech tasks are most commonly used across disorders. Besides popular feature extraction toolkits, many studies utilise custom-built feature sets. Correlations of acoustic features with psychiatric and neurodegenerative disorders are presented. In terms of analysis, statistical analysis for significance of individual features is commonly used, as well as predictive modeling approaches, especially with support vector machines and a small number of artificial neural networks. An emerging trend and recommendation for future studies is to collect data in everyday life to facilitate longitudinal data collection and to capture the behavior of participants more naturally. Another emerging trend is to record additional modalities to voice, which can potentially increase analytical performance.
Patterns and Failure Modes of Fractures Resulting From Forced Folding of Cohesive Caprocks – Comparison of 2D vs. 3D and Single-vs. Multi-Layered Analog Experiments
Authors: Warsitzka Michael , Kukowski Nina , May Franz
Published: July 2022

Knowledge of the formation mechanisms and geometries of fracture systems in sedimentary rocks is crucial for understanding local and basin-scale fluid migration. Complex fracture networks can be caused by, for instance, forced folding of a competent sediment layer in response to magmatic sill intrusion, remobilisation of fluidized sand or fluid overpressure in underlying porous reservoir formations. The opening modes and geometries of the fractures mainly determine the bulk permeability and sealing capacity of the folded layer. In this study, we carried out laboratory analog experiments to better comprehend patterns and evolution of the fracture network during forced folding as well as differences of the fracture patterns between a 2D and 3D modelling approach and between a homogenous and a multi-layered cover. The experimental layering consisted of a lower reservoir layer and an upper cover, which was either a single high-cohesive layer or an alternation of low- and high-cohesive layers. The two configurations were tested in an apparatus allowing quasi-2D and 3D experiments. Streaming air from the base of the model and air injected through a needle valve was used to produce a regional and a local field of fluid overpressure in the layers. The experimental outcomes reveal that the evolution of the fracture network undergoes an initial phase characterized by the formation of a forced fold associated with dominantly compactive and tensile fractures. The second phase of the evolution is dominated by fracture breakthrough and overpressure release mainly along shear fractures. Structures observed in 2D cross sections can be related to their expressions on the surface of the 3D respective experiments. Furthermore, the experiments showed that the intrusion network is more complex and laterally extended in the case of a multi-layered cover. Our results can be instructive for detecting and predicting fracture patterns around shallow magmatic and sand intrusions as well as above underground fluid storage sites.
Study on Critical Damage Width of Parallel Double-Free Surface Blasting
Authors: Shi Jianjun , Miao Xiaopeng , Meng Haili , An Huaming , Zhang Wei
Published: July 2022

Reserved rock wall is usually used in blasting operation when one side has an important protection object. Rock wall demolition blasting was essentially a parallel double-free surface blasting; blasting is the ideal effect of casting a side fully broken rock mass, throwing, on the other side (protection) of rock mass at the injury status of “broken and do not come loose”; the minimum thickness of the rock wall last could hole to protect the width of side of the free surface, called the critical damage width. First, based on the theory of multi-boundary blasting, the relationship among the throwing effect, boundary condition, and charge quantity of parallel double-free surface blasting is expounded in this article. The model of equivalent sub-charge package was established to deduce the relationship of bilateral resistance lines, and the theoretical value of critical damage width was 2.05 W (minimum resistance line). Second, according to the rock wall demolition and blasting of the Yangtou station renovation project in the second line of Yuhuai, the critical damage width of 2.5 W was measured through a single row and hole-by-hole detonation field test. The results of study on critical damage width of parallel double-free surface blasting can provide theoretical guidance for similar projects.
Differences in Imbibition Efficiency Between Bedding and Tectonic Fractures in the Lucaogou Formation in the Jimusar Sag: Evidence From Simulation Experiments
Authors: Liang Chenggang , Liu Aoran , Luo Qun , Luo Jiaguo , Li Dong , Li Peng
Published: July 2022

In addition to tectonic fractures, the ubiquitous and important bedding fractures are often overlooked in the imbibition processes. Based on the identification of different fracture types in tight sandstone from the middle Permian Lucaogou Formation in the Jimusar Sag, NW China, spontaneous imbibition of water experiments was carried out, aiming to investigate the effect of tectonic and bedding fractures on hydrocarbon recovery efficiency in tight reservoir rocks. The results show that the difference in connectivity between the vertical (tectonic fractures) and horizontal (bedding fractures) directions of pores and pore throats is the main reason for the distinction in microscale permeability and, hence, fluid imbibition. The difference in the time required for imbibition between bedding and tectonic fractures is subtle, but the former is slightly lower than the latter in terms of imbibition depth and efficiency. Higher temperatures can shorten the reaction time of imbibition. On the basis that the tectonic fractures are opened, opening the same scale of bedding can increase the imbibition effectiveness by 8.7% at reservoir conditions (27 MPa, 80°C), and the closer to the fracture, the higher the imbibition efficiency in the matrix. The samples with higher porosity and permeability per unit volume have high imbibition oil recovery. However, the imbibition efficiency of the samples with lower porosity and permeability is higher, i.e., the final imbibition efficiency is inversely proportional to porosity and permeability.
Executive Function Skills and Classroom Behaviors of U.S. Prekindergartners With Special Needs
Authors: Nesbitt Kimberly T. , Farran Dale C.
Published: July 2022

This study explores the executive function (EF) skills in a sample of 4-year-old children enrolled in inclusive prekindergarten (pre-k) classrooms. We compare the EF skills and important classroom behaviors of children with and without identified special needs as well as a sample of English language learners (ELL) in the same classrooms. Identification of special needs and ELL status were each examined as these factors have previously been shown to be associated with young children’s EF skills. Compared to their classroom peers, children with identified special needs not only began the year with lower EF skills but made fewer gains over the school year, a similar pattern was observed for children identified as ELL. Compared to their peers, children with identified special needs were observed as engaging in lower levels of involvement, sequential behaviors, and social learning interactions and higher levels of unoccupied and disruptive behaviors, a pattern that was also found for children’s entering EF skills (e.g., lower entering EF scores associated with lower levels of involvement). Lastly, children’s classroom behaviors differed across teacher-directed and children-directed learning with level of involvement and social-learning interactions higher during child-directed learning, and sequential behaviors higher in teacher-directed learning, a pattern that held across all groups of children.
A Comprehensive Review of the On-Road Wireless Charging System for E-Mobility Applications
Authors: S Yuvaraja , R Narayanamoorthi , Sathik Mohamed Ali Jagabar , Almakhles Dhafer
Published: July 2022

The recent progress in the dynamic wireless power transfer (DWPT) system brings feasibility to increase the driving range of an electric vehicle (EV). The on-road wireless charging system reduces the volume of the EV’s battery and charging the vehicle while driving. So, the powered roadways can potentially decrease the dependency on heavy-sized batteries for EV applications. The capability of transferring maximum power from the ground surface to the vehicle requires the critical design of the entire DWPT system. The various factors such as wireless charging pads, power electronic converters, compensators, and controllers influence the power transfer rate of the system. An appropriate impedance matching network assists the system during power transfer. Moreover, the design of coils in DWPT needs to consider the sensitive misalignment tolerance, safety issues, complex design, and cost factors. In this article, the basic topologies, history, and fundamentals of the DWPT charging system are discussed. In addition, the impact on the power grid due to the DWPT system and factors involved in microgrid integration are discussed. However, the current scenario of different compensators, converters, and design topologies proposed in the dynamic charging system is included. This article presents a comprehensive overview and challenges involved in a DWPT system such as the design of a power converter, charging couplers, compensation network, foreign object detection system, economic factors, and microgrid-integrated DWPT system. An economic analysis, electromagnetic compatibility, and interference of the charging system are also analyzed vastly. The human exposure level with its allowable limits developed for the wireless power transfer system is discussed.
A Hybrid Data-Driven Method to Predict Battery Capacity of Medical Devices and Analyze Component Effects
Authors: Fang Run , Liao Chengsheng , Quan Hong , Zeng Libo , Peng Qiao
Published: July 2022

Lithium-ion batteries are currently the most utilized power source in medical devices due to their long service life, high energy performance, and being portable. The performance of battery-powered medical devices is heavily dependent on battery capacity, which would be directly affected by related battery component parameters. To widen the application of battery-powered medical devices, it is vital to effectively monitor battery capacity and analyze the effects of battery component parameters. This article derives a hybrid data-driven method to achieve accurate early predictions of battery capacity and reliable analysis of battery component effects. To be specific, a Gaussian process regression-based data-driven model is first developed to efficiently capture the underlying fitting among four component parameters and battery capacity. Then two effect analysis tools including the automatic relevance determination kernel-based weights and tree-based local interpretable model-agnostic explanation are equipped to quantify and analyze both global and local effects of these four component parameters, respectively. Illustrative results show that the designed hybrid data-driven method is able to provide accurate battery capacity predictions with 0.97R2, while both global effects and local effects of four component parameters are successfully quantified. Due to the merits of data-driven characteristics, the designed hybrid data-driven method is capable of efficiently helping users to monitor/predict battery capacity and analyze/understand the effects of interested component parameters. This could further benefit battery-powered medical devices for higher-performance and longer-lifetime applications.
Power Grid Monitoring Event Recognition Method Integrating Knowledge Graph and Deep Learning
Authors: Yang Yinbin , Hu Qinran , Liu Yi , Pan Xiaohui , Gao Shang , Hao Baoxin
Published: July 2022

“Eventization” of power grid monitoring is an effective way to deal with massive alarm information. The existing event recognition method adopts the method of text information mining, and the overall recognition accuracy is not high. Therefore, this paper proposes a power grid monitoring event recognition method integrating knowledge graph and deep learning. First, the method constructs the knowledge graph of monitoring equipment and uses the improved GraphSAGE (graph sample and aggregate) algorithm to perform representation learning on the graph, and integrate the structural characteristics of monitoring equipment into the generated alarm vectors. Then, the GRU (Gated Recurrent Unit) neural network trains the alarm vectors and related events. In addition, this paper combines the proposed method with the existing monitoring expert system, and puts forward a monitoring event recognition strategy. Finally, through the case analysis and comparison of the actual data of the power grid, the effectiveness of the proposed method and strategy is verified, which further improves the accuracy of monitoring event recognition.
Monitoring Dryland Trees With Remote Sensing. Part A: Beyond CORONA—Historical HEXAGON Satellite Imagery as a New Data Source for Mapping Open-Canopy Woodlands on the Tree Level
Authors: Marzolff Irene , Kirchhoff Mario , Stephan Robin , Seeger Manuel , Aït Hssaine Ali , Ries Johannes B.
Published: July 2022

Monitoring woody cover by remote sensing is considered a key methodology towards sustainable management of trees in dryland forests. However, while modern very high resolution satellite (VHRS) sensors allow woodland mapping at the individual tree level, the historical perspective is often hindered by lack of appropriate image data. In this first study employing the newly accessible historical HEXAGON KH-9 stereo-panoramic camera images for environmental research, we propose their use for mapping trees in open-canopy conditions. The 2–4 feet resolution panchromatic HEXAGON satellite photographs were taken 1971–1986 within the American reconnaissance programs that are better known to the scientific community for their lower-resolution CORONA images. Our aim is to evaluate the potential of combining historical CORONA and HEXAGON with recent WorldView VHRS imagery for retrospective woodland change mapping on the tree level. We mapped all trees on 30 1-ha test sites in open-canopy argan woodlands in Morocco in the field and from the VHRS imagery for estimating changes of tree density and size between 1967/1972 and 2018. Prior to image interpretation, we used simulations based on unmanned aerial system (UAS) imagery for exemplarily examining the role of illumination, viewing geometry and image resolution on the appearance of trees and their shadows in the historical panchromatic images. We show that understanding these parameters is imperative for correct detection and size-estimation of tree crowns. Our results confirm that tree maps derived solely from VHRS image analysis generally underestimate the number of small trees and trees in clumped-canopy groups. Nevertheless, HEXAGON images compare remarkably well with WorldView images and have much higher tree-mapping potential than CORONA. By classifying the trees in three sizes, we were able to measure tree-cover changes on an ordinal scale. Although we found no clear trend of forest degradation or recovery, our argan forest sites show varying patterns of change, which are further analysed in Part B of our study. We conclude that the HEXAGON stereo-panoramic camera images, of which 670,000 worldwide will soon be available, open exciting opportunities for retrospective monitoring of trees in open-canopy conditions and other woody vegetation patterns back into the 1980s and 1970s.
A Gravity Model Analysis of China’s Trade in Renewable Energy Goods With ASEAN Countries as Well as Japan and South Korea
Authors: Zhang Wei , Yu Kaiyi , Fang Yingying
Published: July 2022

Focusing on the components of both solar photovoltaic technology and wind energy technology and using the gravity model approach with panel data, this study empirically investigated the determinants of bilateral trade in renewable energy goods among ASEAN countries as well as with China, Japan, and South Korea for the period 2012–2019, and also identified China’s export efficiency and export potential. The results showed that the economic sizes of both the exporting and importing countries, the economic freedom of the exporter, and trade agreements and membership of common trade areas significantly encouraged bilateral trade, while geographical distance exerted a significantly negative influence. In general, it was found that China had great potential to export renewable energy goods. We propose that the ASEAN Plus Three region needs to formulate and implement a comprehensive and carefully coordinated renewable energy policy package. We also suggest that China should promote joint efforts with ASEAN, Japan and South Korea to further deepen cooperation on the low-carbon economy and tap the great potential for trade in renewable energy goods.
Identification of circRNA–miRNA–mRNA Regulatory Network and Crucial Signaling Pathway Axis Involved in Tetralogy of Fallot
Authors: Kan Zunqi , Yan Wenli , Wang Ning , Fang Yuqing , Gao Huanyu , Song Yongmei
Published: July 2022

Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart diseases (CHD) worldwide; however, its pathogenesis remains unclear. Recent studies have shown that circular RNAs (circRNAs) act as “sponges” for microRNAs (miRNAs) to compete for endogenous RNA (ceRNA) and play important roles in regulating gene transcription and biological processes. However, the mechanism of ceRNA in TOF remains unclear. To explore the crucial regulatory connections and pathways of TOF, we obtained the human TOF gene, miRNA, and circRNA expression profiling datasets from the Gene Expression Omnibus (GEO) database. After data pretreatment, differentially expressed mRNAs (DEmRNAs), microRNAs (DEmiRNAs), and circRNAs (DEcircRNAs) were identified between the TOF and healthy groups, and a global triple ceRNA regulatory network, including circRNAs, miRNAs, and mRNAs based on the integrated data, was constructed. A functional enrichment analysis was performed on the Metascape website to explore the biological functions of the selected genes. Then, we constructed a protein-protein interaction (PPI) network and identified seven hub genes using the cytoHubba and MCODE plug-ins in the Cytoscape software, including BCL2L11, PIK3R1, SOCS3, OSMR, STAT3, RUNX3, and IL6R. Additionally, a circRNA–miRNA–hub gene subnetwork was established, and its enrichment analysis results indicated that the extrinsic apoptotic signaling pathway, JAK-STAT signaling pathway and PI3K-Akt signaling pathway may be involved in the pathogenesis of TOF. We further identified the hsa_circ_000601/hsa-miR-148a/BCL2L11 axis as a crucial signaling pathway axis from the subnetwork. This study provides a novel regulatory network for the pathogenesis of TOF, revealing the possible molecular mechanisms and crucial regulatory pathways that may provide new strategies for candidate diagnostic biomarkers or potential therapeutic targets for TOF.