bluuebunny/crossref_metadata_2025 huggingface dataset:
Los niños prodigio del cine español: aproximación a la educación de los años 50 y 60
Authors: Durán Manso Valeriano
Published: July 2018

El cine español protagonizado por los denominados niños prodigio ofrece una aproximación a la educación de las décadas de los cincuenta y sesenta del siglo XX. Durante el régimen de Francisco Franco, la gran pantalla se convirtió en un vehículo de propaganda mediante películas históricas que ensalzaban valores patrióticos, y otras de evasión como comedias románticas, musicales y folklóricas interpretadas por cantantes. Tras veinte años de dictadura, España decidió salir de su aislamiento económico, y, en consecuencia, el modelo de cine imperante empezó a cambiar para dar una imagen de modernidad ante Europa. Así, el más comercial incorporó a niños que además de actuar cantaban, y estas películas –que son patrimonio cultural español-, tuvieron una gran repercusión tanto en el público infantil y familiar nacional como a nivel internacional. Los filmes de Pablito Calvo, Joselito, Marisol y Rocío Dúrcal –los cuatro niños prodigio más importantes-, siguieron los cánones morales establecidos por el franquismo pero intentaron a la vez mostrar una sociedad moderna, sobre todo, los de las niñas. Esto se reflejó especialmente en la educación a través del tipo de familia de los protagonistas, su arraigada religiosidad, el ámbito escolar al que pertenecían y el vínculo con sus docentes, y, además, las relaciones entre chicos y chicas. Desde estas consideraciones, este trabajo reflexiona sobre cómo era la educación en estas décadas y cómo la representación de la escuela, el profesor, los centros educativos, y la enseñanza en el cine español de los niños prodigio constituyó un arma propagandística del franquismo.
Missões de pesquisa: inventariando a documentação escolar do sertão baiano
Authors: Santos Vânia Muniz dos , Miguel Antonieta
Published: July 2018

O Projeto Missões de Pesquisa: levantamento e catalogação de fontes sobre a História da Educação no interior baiano consiste em ações que viabilizem o inventário e a construção de um banco de dados sobre a documentação escolar dispersa entre arquivos de diferentes natureza e envolve discentes, docentes e egressos do Departamento de Ciências Humanas – DCH – Campus VI, da Universidade do Estado da Bahia. O projeto se iniciou em 2014, como desdobramento das atividades do Núcleo de Pesquisa sobre História Social e Prática de Ensino (NHIPE) e do Laboratório de Pesquisa e Didática da História (LAPEDHI) e já realizou quatro viagens de campo para municípios circunvizinhos. Os documentos localizados foram fotografados e catalogados em ficha específica, posteriormente estas informações são digitadas, formando um banco de dados que será disponibilizado para pesquisadores da área. A necessidade de conservação de documentos relacionados e advindos de escolas em quaisquer ambientes é de extrema importância para as pesquisas na temática. Alguns resultados já foram alcançados com as Missões, entre eles duas monografias que discutem a História da Educação e das Instituições escolares, bem como, três projetos de pesquisa na temática, dois projetos de iniciação científica e produções científicas como artigos e relatos de experiência apresentados em eventos regionais e internacionais. Dessa maneira, o Projeto Missões de Pesquisa: levantamento e catalogação de fontes sobre a História da Educação no interior baiano contribui para a difusão e proteção do patrimônio histórico educativo da Bahia ao inventariar documentos escolares dispersos que servirão de fonte para futuras pesquisas.
A organização da biblioteca da Escola Normal de Campinas - o mapeamento das coleções pedagógicas (1930-1960) nos apontamentos de uma pesquisa
Authors: Menezes Maria Cristina , Pinheiro Maria de Lourdes
Published: July 2018

A presente discussão articula-se ao projeto “Patrimônio Histórico Educativo: a organização da Biblioteca da Escola Normal de Campinas” e vincula-se às ações desenvolvidas nos projetos do CIVILIS (Grupo de Estudos e Pesquisas em História da Educação, Cultura Escolar e Cidadania), da Faculdade de Educação da UNICAMP, sob a coordenação da Profa. Dra. Maria Cristina Menezes. A discussão parte de uma proposta de pesquisa que tem como objetivo fazer o levantamento das coleções pedagógicas da biblioteca da antiga Escola Normal de Campinas. Os títulos foram organizados por coleções e a pesquisa busca procedimentos de identificação e descrição dos itens. A organização desses espaços, por consequência, é uma importante contribuição para a preservação do patrimônio históricoeducativo.
Reivenções de si: acervos pessoais e o uso de escritas ordinárias como fontes para produção histórica
Authors: Vieira Letícia
Published: July 2018

“Viver e Escrever: cadernos de escritas ordinárias de um professor catarinense (Sec XX)”, livro de autoria de Maria Teresa Santos Cunha e Flávia de Freitas Souza, configura-se como escrito de base por trazer à cena estudos acerca dos cadernos e colocar em pauta a questão das escritas ordinárias enquanto testemunhos de construções de si. Tomando por objeto de estudo parte do acervo pessoal do intelectual catarinense Victor Márcio Konder, e destinando atenção à descrição do processo de restauro, organização e salvaguarda do material componente desta parcela do acervo - especificamente um conjunto de quarenta e cinco cadernos manuscritos produzidos pelo professor entre as décadas de 1960 e 1980 -, a obra convida-nos ao debate acerca do uso de cadernos enquanto fonte para produção histórica, levando-nos a atentar à estes documentos, “portadores de ressonâncias”, e aos rastros que habitam cada espaço destes enquanto suportes de escrita.
As conferências do curso para professores do Barão Degerando – 1839
Authors: Cason Silvia Regina
Published: July 2018

O documento trata-se do: Curso Normal Para Professores de 1ªs letras ou Direções Relativas a Educação Physica, Moral e intelectual. Nas Escolas Primárias - Pelo Barão Degerando - Impresso por ordem do Governo Provincial do Rio de Janeiro. Para uso dos Professores, Traduzido e acrescentado com um apêndice de Leis Gerais e Provinciais Sobre escolas. pelo Dr. João Candido de Deos e Silva. Nictheroy. Typographia Nictheroy de M.G. de S. Rego, Praça Municipal – 1839; 421 páginas, que se encontra na Biblioteca Nacional do Rio de Janeiro, cujo original está na Biblioteca Nacional da França.
A produção do inventário da coleção da Profª. Maria Luiza Cardoso sobre a história do ensino militar: perspectivas e desafios
Authors: Cardoso Maria Luiza
Published: July 2018

Este trabalho teve como objetivo descrever o processo de organização do acervo de documentos pessoais da Profa. Dra. Maria Luiza Cardoso sobre o ensino nas instituições militares. A referida docente trabalhou mais de 31 anos, como militar, na área educacional da Força Aérea Brasileira (FAB). A organização da Coleção envolve: 1) a viabilização do trabalho de higienização, acondicionamento e tratamento adequado dos documentos que compõem os seus subfundos arquivísticos; 2) a identificação, a descrição e a classificação do acervo histórico; 3) a digitalização dos documentos referentes aos subfundos, visando constituir um banco de dados sobre a documentação manuseada; e 4) a disponibilização para consultas e pesquisas de todo o material registrado do acervo através da elaboração de um DVD.
Arrièrés Pédagogiques: naissance de l’élève capacitaire dans les dernières recherches de Binet dans les écoles parisiennes en 1908-1910
Authors: Andrieu Bernard
Published: July 2018

L’élève capacitaire est autant celui qui pathologiquement manifesterait des carences et des déficits neurocognitifs que Binet et Simon décrivent comme un enfant anormal mais concerne aussi avec Vaney et les commissions pédagogique de la Société Binet-Simon les classes ordinaires dans lesquelles les différences de niveau d’intelligence ne sont pas réalisés. Epistémologiquement le projet de Binet avec d’une part le psychiatre Théodore Simon et d’autre part avec le directeur d’école Victor Vaney est double: - L’éducabilité peut être comprise dans une classification psychiatrique qui, depuis Belhomme jusqu’à Bourneville, propose une graduation dans les capacités d’apprentissage en délimitant les possibilités d’apprentissage, ce que nous appelons le niveau capacitaire de lélève dès la petit école de Borneville; - Alfred Binet travaillant avec Victor Vaney au laboratoire de l’école de la Grange aux Belles mais aussi dans les autres écoles parisiennes via les autorisations obtenues auprès de l’inspecteur Belot pour enquêter comme nous le montrons dans ces  archives auprès des arriérés pédagogiques des classes ordinaires.
Las misiones culturales: un proyecto de educación y salud en el medio rural mexicano del siglo XX
Authors: Martínez Moctezuma Lucia
Published: July 2018

Una vez terminado el periodo de guerra civil en México (1910-1917) se implementó una vasta campaña de educación higiénica que identificó la influencia de la escuela para difundir diferemtes ideas sobre los beneficios de la vacunación  y el cuidado de la salud del ciudadano. En este trabajo, me propongo dar cuenta de la práctica de las Misiones Culturales que llegarán a las comunidades rurales para desarrollar una cultura física y educar a los ciudadanos para combatir enfermedades y proteger su salud. En este cambio se percibe una transformación del proyecto educativo mexicano, a saber,  la sustitución del modelo escolar europeo que privilegia el entorno urbano desde 1880, por otro norteamericano en las primeras décadas del siglo XX, que atiende a la comunidad rural con el apoyo de un equipo de trabajo en el que participan inspectores, directores, profesores de diferentes especialidades, médicos, enfermeras, padres de familia y la comunidad rural en su conjunto.
La atención sanitaria infantil como preocupación educativa
Authors: Padrós Núria , Prat Pilar , Collelldemont Eulàlia
Published: July 2018

El análisis de la normativa oficial nos permite proponer la hipótesis de estudio que la atención sanitaria infantil ocupó un lugar predominante en las preocupaciones educativas de la primera mitad del siglo XX en España. Para realizar la investigación nos hemos centrado en analizar los filmes de propaganda educativa que se realizaron en este contexto. Concretamente, hemos secuenciando aquellos elementos de forma y de contenidos que aparecen en los filmes. En este artículo se presentan los resultados de la investigación llevada a cabo para contrastar dicha hipótesis.
Enfermería en lña educación y salud en la escuela: un asunto de cuidado y poder. 1920-1990
Authors: Gomez Ochoa Ana Maritza
Published: July 2018

El trabajo, de orientación arqueológica-genealógica, describe la relación educación y salud a partir de la práctica pedagógica debatida entre el cuidado y el poder en la escuela Colombiana: 1920-1990, como asunto de gobierno; revisa el paso de un sujeto higiénico a un sujeto saludable y cuestiona la potencia que tuvo esta relación como proyecto político y social, a partir de la prevención y promoción. La enfermera en su condición de género y educadora se hizo necesaria en la escuela, su práctica involucró acciones pedagógicas para cambiar hábitos en pro de un país moderno.
Colégio Estadual Governador Luiz Viana Filho (1956-1994): história, arquivo escolar e produção de catálogo de fontes
Authors: Souza Maryana Gonçalves , Miguel Antonieta
Published: July 2018

O presente texto é resultado do projeto Colégio Estadual Governador Luiz Viana Filho: instituição, arquivo escolar e possibilidades de pesquisa (1956-1994), com apoio financeiro do PICIN/UNEB que almeja conhecer, inventariar e catalogar os documentos da instituição e produzir um Catálogo de Fontes Primárias, apresentando a documentação pesquisada e suas possibilidades de pesquisa em História da Educação. Os documentos foram levantados e catalogados, realizando a análise do seu conteúdo e seu estado. Depois se realizou a produção escrita e gráfica do Catálogo. A pesquisa desenvolvida permitiu visualizar a potencialidade das instituições escolares e seus arquivos e a situação crítica deste local, necessitando descontruir a invisibilidade social perante os espaços escolares e seu patrimônio.
Apresentação de livro
Authors: Domínguez Pablo Álvarez
Published: July 2018

El patrimonio educativo tiene un importante valor histórico como fuente para el conocimiento del pasado y, tanto por esta condición, como por su capacidad para estimular el recuerdo y perpetuar la memoria de la educación, requiere y merece ser estudiado, preservado, difundido y puesto al servicio de la comunidad.
Apresentação de livro
Authors: Menezes Maria Cristina
Published: July 2018

Livro organizado como volume 1 da COLEÇÃO PATRIMÔNIO HISTÓRICO EDUCATIVO, coordenada por Maria Cristina Menezes e Carmen Sylvia Vidigal Moraes.
Arte, cine, educación. Aprender arte con el cine
Authors: Martínez-Salanova Sánchez Enrique
Published: July 2018

El cine compendia y se basa en todas las artes. Más que ninguna otra las utiliza, trasvasa y recrea, necesita de ellas, las mejora y las difunde. Sin la literatura y los escritores, sean de novela, cuento, guión o poesía, el cine no tendría argumentos. Sin la fotografía, la pintura, la escultura y la arquitectura, no tendrían soporte estético ni justificación teórica. Sin la música y la danza, la luz o el color no podría expresarse en su plenitud. Sin las ciencias, la física y la química, la tecnología o la informática, el cine no tendría base material en que sustentarse. El cine, además, conduce a la tecnología hacia el arte, reproduce la luz y el color y eleva el movimiento y el ritmo a las alturas de las artes llamadas ‘nobles’ para generar la fantasía, la ficción y la realidad. El cine, además, reproduce historias de pintores, literatos y escultores, utiliza para sus mensajes alternativas y cromatismos que nacieron para otras artes.
Potencialidades de um arquivo escolar: o caso do Núcleo de Documentação e Memória do Colégio Pedro II
Authors: Cardoso Tatyana Marques de Macedo , Oliveira Claudia Maria Costa Alves de
Published: July 2018

O presente trabalho tem como objetivo apresentar o potencial histórico arquivístico do Núcleo de Documentação e Memória do Colégio Pedro II (NUDOM) para as pesquisas acadêmicas a partir do seu vasto acervo. Essa instituição secular de ensino, criada em 1837, localizada no Centro do Rio de Janeiro, se constitui em um “lugar de memória”, personagem/objeto, patrimônio da História da Educação Brasileira. O acervo documental deste Núcleo tem valor inestimável para a instituição e alto grau de relevância para a pesquisa, pois dimensiona a importância do Colégio no desenvolvimento da Educação Brasileira.
Do Ginásio Industrial de Petrolina à Escola Marechal Antônio Alves Filho: vestígios da cultura escolar (1962-1971)
Authors: Ávila Virgínia Pereira da Silva de , Santos Kalline Laira Lima dos
Published: July 2018

Neste texto, apresentam-se resultados da pesquisa investigativa que analisou vestígios da cultura escolar presentes na documentação do primeiro ginásio do município de Petrolina, no Sertão do São Francisco, no período entre 1962 e 1971. A pesquisa se apoiou nos textos legislativos, bem como nas fichas individuais e antropométricas, por meio dos quais buscou identificar as práticas culturais e o perfil socioeconômico e educacional dos(as) alunos(as). A delimitação temporal compreende o ano de fundação do ginásio e a mudança de nomenclatura advinda com a Lei n. 5.692/71. Com relação ao referencial teórico, privilegiou-se o diálogo entre autores (as) do campo da História e da Historiografia da Educação, mais especificamente aqueles relacionada à História Cultural. Os dados iniciais permitiram identificar o papel do antigo ginásio na difusão da cultura, das atividades esportivas e da fé nos diferentes espaços da cidade. Por fim, o trabalho aponta para um conjunto de possibilidades para investigações futuras.
A Maison Deyrolle, de Paris, na Escola Normal de Campinas
Authors: Menezes Maria Cristina , Castro Wagner Borges , Silva Cecília Melo da , Alves Débora Pereira
Published: July 2018

O documento em destaque traz ofício do Diretor da Escola Complementar de Campinas, que foi a denominação que a Escola Normal de Campinas carregou de 1903 a 1911, ao Secretario do Interior de São Paulo, com os dados para a compra dos Gabinetes de physica, chimica e história natural, que já havia sido autorizada.
A Systematic Review Research: ‘Mathematics Anxiety’ in Turkey
Authors: Alkan Vesile
Published: July 2018

The aim of this study was to conduct a
systematic review research concentrating on studies regarding ‘Mathematics anxiety’. 59 papers were
reanalyzed in order to answer the questions derived from the main aim in terms
of the rules of systematic review method. These studies were reviewed and
analyzed by taking account of their aims, designs, sampling and results. While
doing this, the similarities and differences of the reviewed studies were also
found. It was seen that most of these studies conducted with middle school
students. It was also found that the majority of reviewed studies were designed
according to quantitative approaches. The review shows that mathematics anxiety
is resulted from students’ achievement, self-efficacy and fear along with
parents’ and teachers’ lack of supports in mathematics. The results gathered
from reviewed studies suggest that studies designed with approaches like
qualitative and mixed-method and studies focused on various topics related with
‘Mathematics anxiety’ with different
sampling are needed. In conclusion, this systematic review study provides some
fruitful information for the area and so for the further studies.
Mesoscopic electron transport and atomic gases, a review of Frank W. J. Hekking's scientific work
Authors: Amico Luigi , Basko Denis , Bergeret F. Sebastian , Buisson Olivier , Courtois Hervé , Fazio Rosario , Guichard Wiebke , Minguzzi Anna , Pekola Jukka , Schön Gerd
Published: July 2018

In this article, we provide an overview of the scientific
contributions of Frank W. J. Hekking to the fields of mesoscopic
electron transport and superconductivity as well as atomic gases. Frank
Hekking passed away in May 2017. We hope that the present review gives a
faithful testimony of his scientific legacy.
On the coupling of Galilean-invariant field theories to curved spacetime
Authors: Jensen Kristan
Published: July 2018

We consider the problem of coupling Galilean-invariant quantum field
theories to a fixed spacetime. We propose that to do so, one couples to
Newton-Cartan geometry and in addition imposes a one-form shift
symmetry. This additional symmetry imposes invariance under Galilean
boosts, and its Ward identity equates particle number and momentum
currents. We show that Newton-Cartan geometry subject to the shift
symmetry arises in null reductions of Lorentzian manifolds, and so our
proposal is realized for theories which are holographically dual to
quantum gravity on Schrödinger spacetimes. We use this null reduction to
efficiently form tensorial invariants under the boost and particle
number symmetries. We also explore the coupling of Schrödinger-invariant
field theories to spacetime, which we argue necessitates the
Newton-Cartan analogue of Weyl invariance.
Biogas as an alternative energy resource for Ukrainian companies: EU experience
Authors: Yevdokimov Yuri , Chygryn Olena , Pimonenko Tetyana , Lyulyov Oleksii
Published: July 2018

The paper deals with analysis of the preconditions of alternative energy market development in Ukraine. In this case study, the authors analyzed the EU experience. The results of analysis showed that the leader of the EU countries in renewable energy has already achieved the target (20%), which had been indicated. In addition, the findings showed that the share of renewable energy in gross final energy consumption has been increasing from year to year. The authors allocate that, according to the Ukrainian potential, biogas is the most perspective one among alternative resources. Moreover, results of analysis showed that Ukraine has the huge potential of agricultural sector. In this direction, the authors allocated the main types of the agricultural activities, which have the highest potential of biogas production: sugar factories, corn silage and poultry farms. The authors underlined that biogas spreading is restrained by the stereotypes that green investments are not attractive for investors. In order to analyze the economic efficiency of investments to the biogas installation, the authors calculated the profit from the biogas installation for poultry farm. The authors made two scenarios for calculation. The first – the whole volume of energy, which was generated from the biogas unit, will be sold with feed-in tariff. The second – the farm covers its own needs in electricity, the rest will be sold with feed-in tariff. The findings showed that the first scenario is more attractive. Moreover, the farm could receive higher profit if it installed the biogas in 2016, not in 2017. In addition, based on the EU experience and features of farm functioning, the authors approved that the biogas installation has not only the economic effect (profit and additional profit) for company, but also ecological and social effects for rural area, where this farm was located.
Serebral Palsili Öğrenciler İçin Düzenlenmiş Bir Okulda Gerçekleştirilen Kaynaştırma Modeline İlişkin Paydaş Görüşleri
Authors: YAZICIOĞLU Tansel , KARGIN Tevhide
Published: July 2018

Çoğunlukla
tam zamanlı olarak yapılan kaynaştırma eğitimi ülkemizde 1983 yılından beri
uygulanmaktadır. O tarihten günümüze kaynaştırma eğitimi uygulamalarının arttığı
ancak kaynaştırma eğitimi modeli girişimlerinin sınırlı kaldığı dikkat
çekmektedir. Bu araştırmanın genel amacı Türkiye’de ilk defa Serebral Palsili
öğrencilerin devam ettiği bir okulda pilot proje olarak geliştirilen
kaynaştırma eğitimi modelinin uygulanmasına ilişkin öğretmenler, özel
gereksinimli olan ve olmayan öğrenciler, özel gereksinimli olan ve olmayan
öğrencilerin aileleri gibi tüm paydaşların görüşlerini belirlemektir. Bu amaç
doğrultusunda kaynaştırma eğitimi modeli uygulayan okulda görev yapan
öğretmenlerin, okulda öğrenim gören öğrencilerin ve bu öğrencilerin ailelerinin
görüşleri alınmıştır. Nitel araştırma yöntemlerinden betimsel yöntemin
kullanıldığı araştırmada veriler görüşmeye dayalı tümevarım analiz tekniği ile
analiz edilmiştir. Uygulanan kaynaştırma eğitimi modelinin sorunlarını
çözebilmek ve modeli daha etkili hale getirebilmek için öğretmen, öğrenci ve
ailelerin önerilerinin dikkate alınması gerekmektedir.
Effect of Doxycycline on Aseptic Reperfusion Injury in Ovarian Torsion
Authors: Bektas Gizem , Karasu Yetkin , Yurtcu Engin , Togrul Cihan , Özyer Sen Sebnem , Onder Dirican Aylin , Uzunlar Ozlem , Gungor Tayfun , Caydere Muzaffer
Published: July 2018

Objective: Reperfusion injury occurs when the condition causing ischemia in ovarian torsion is corrected and the blood supply is re-established. The aim of this study is to evaluate whether doxycycline treatment reduces reperfusion injury in a rat model.Study Design: Thirty-five female albino Wistar rats were split into the five groups. Sham: Sham operation; ischemia (I): 2 hours of ischemia; ischemia and reperfusion (I/R): 2 hours of ischemia followed by 2 hours of reperfusion; Sham-Dc: Sham operation and doxycycline 10-mg/kg (2 hours prior to surgery); I/R-Dc: 2-hours of ischemia and doxycycline 10-mg/kg and 2-hours of reperfusion. The groups were compared in terms of histological and biochemical features. A semi-quantitative histological assessment scoring system was used for the histological examination. Follicular cell degeneration, vascular congestion, haemorrhage and inflammatory cell count were evaluated for histological analysis. For biochemical analysis of reperfusion injury, the body's total antioxidant status and total oxidant status were measured using a fully automatic method. The oxidative stress index was calculated by dividing total antioxidant status by total oxidant status.Results: In the sham group the ovaries were histologically normal. Oedema, vascular congestion, bleeding, leukocyte infiltration and follicle degeneration were increased in other groups (p<0.05). There was less leukocyte infiltration in the I/R-Dc group compared to I/R group. Other histological features were similar in these groups. Doxycycline increased the malondialdehyde, total antioxidant and total oxidant status levels in Sham-Dc and I/R-Dc groups. This increase was statistically significant between Sham and Sham-Dc groups. However, although there was an increase in the biochemical markers in the I/R-Dc group, this increase was not significant compared to I/R group.Conclusion: Doxycycline treatment in ovarian torsion does not reduce I/R injury. Doxycycline may even increase reperfusion injury, according to biochemical findings.
Venlafaxine Determination in Pharmaceutical Formulation and Serum by Ion-Selective Electrodes
Authors: Mansour Marwa F. , El-Moety Mona M. Abd , El Kady Ehab F. , El Guindi N.M. , Schepdael Ann Van , Aly S.M. El-Moghazy
Published: July 2018

Background:

The application of an ion selective technique for the determination of analyte concentrations
is considered one of the most economical techniques for quality control purposes.

Objective:

To elaborate and investigate the construction and general performance characteristics of potentiometric
PVC membrane sensors for venlafaxine cation (Ven+).

Method:

The sensors are based on the use of the ion association complexes of the venlafaxine cation with phosphotungstate
(PT) and silicotungstate (ST) counter anions as ion exchange sites in the plasticized PVC matrix.
They are characterized by potentiometric and conductimetric measurements, performed under various conditions.

Results:

The electrodes showed a fast (response time around 15 s), stable (life span 45 days) and linear (r2 0.995)
response for venlafaxine over the concentration range of 5x10-5 - 1x10-2 M venlafaxine hydrochloride. The solubility
product of the ion pair and the formation of the precipitation reaction leading to the ion pair, were determined
conductimetrically. The electrodes were found to be very selective, precise (RSD < 1%) and applicable to
the potentiometric determination of venlafaxine hydrochloride in pure solutions or in pharmaceutical preparation
and in biological fluid (serum), without any interference. Validation of the method shows the suitability of the
proposed electrodes for use in the quality assessment of venlafaxine hydrochloride.

Conclusion:

Using only a pH meter in combination with the selective electrodes, drug substance or drug product
could be determined accurately in a few seconds. In addition, the in-house made electrodes were tested to monitor
venlafaxine in serum. Acceptable results were achieved using the standard addition technique.
Next-generation Metabolomics in the Development of New Antidepressants: Using Albiflorin as an Example
Authors: Han Jian , Xia Yonghong , Lin Lejun , Zhang Zuoguang , Tian Hui , Li Kefeng
Published: July 2018

Depression is a highly prevalent disorder that affects more than 300 million adults worldwide in 2015.
Depression also frequently coexists with many other conditions such as osteoporosis and one-third of the
Intensive Care Unit (ICU) survivors had depressive symptoms. Antidepressants have become the most commonly
prescribed drugs in the United States. In addition to the regular process, drug discovery and development (R&D)
for depression presents extra challenges because of the heterogeneity of the symptoms and various co-occurring
disorders. Botanical medicine with multi-functional nature has been proposed to be more effective, providing
rapid control of core and comorbid conditions of depression. With the technical advances in analytical instruments,
metabolomics is entering into a “new generation”. Next-generation metabolomics (NGM) has the capability
to comprehensively characterize drug-induced metabolic changes in the biological systems. NGM has demonstrated
great potential in all the stages of pharmaceutical R&D in the last 10 years. Albiflorin isolated from Peony
roots is a promising drug candidate with multi-target for depression and is currently under development by Beijing
Wonner Biotech. In this work, we summarized the common analytical platforms for NGM and its main applications
in drug R&D. We used albiflorin as an example to illustrate how NGM improves our understanding of
drug candidate actions and facilitates drug safety evaluation. Future directions on how to expand the use of NGM
for new antidepressant development in pharmaceutical industry were also discussed.
Medicinal Plants: A Complementary and Alternative Antidepressant Therapy
Authors: Ismail Hammad , Amanat Muhammad Ammar , Iqbal Adnan , Mirza Bushra
Published: July 2018

There is enough data available now to believe that nature has provided cure of almost every ailment
through herbal medicine or management. Therefore, now there is lot of emphasis on identification, evaluation,
development and characterization of numerous plants and their active constituents against several diseases including
depression. Depression is not only one of the most common ailments but also a highly complex condition to
study. Even though several antidepressant drugs are available now, yet their effectiveness and usefulness are
highly questionable especially because of their side effects. As herbal remedies are generally associated with
favourable safety profiles therefore they have the possible potential to deliver effective replacements to currently
available synthetic antidepressants. More recently, efforts have been focused on characterization of pharmacologically
active ingredients and to identify the mode of action of herbal antidepressant medicines. This review
describes a brief introduction of different animal models for depression and discusses the advantages and disadvantages
for each approach. Then we have summarized possible plant phytochemicals as antidepressant drug and
their underlying mechanisms. In the main body of the review, we have discussed in detail the most frequently
used plants (21) being investigated for the treatment of depression. Additionally, we have provided the list of
medicinal plants (92) representing their origin, parts used, extraction method, evaluation method and possible
active ingredient. In the final part of the review we have presented the summary of clinical trials on the use of
medical plants for depression and their active constituents.
Biological Effects of Licochalcones
Authors: Maria Pia Gatta Daniela , Sara Franceschelli , Mario Felaco , Lorenza Speranza
Published: July 2018

Medicinal plants and their natural bioactive molecules, are evaluated as the foundation for health preservation and care of humanity. The licorice root, known as “Radix Glycyrrhizae”, is a perennial plant that comes from Mediterranean countries, central to southern Russia, Asia, Turkey, Iraq and Iran. The licorice root has been used in traditional Chinese medicines for centuries and has been defined as "the progenitor of herbs". The name 'Licorice' is derived from the ancient Greek word Glukurrhiza, meaning 'sweet root'. It consists of approximately 30 species, however, the most common ones consist of Glycyrrhiza glabra L., Glycyrrhiza uralensis Fisch and Glycyrrhiza Inflata. In addition, the licorice root contains chalcones, which are a part of an important class of natural products and are precursors of flavonoids. Chemically, chalcones are composed of two aromatic rings associated with α, β-unsaturated α-carbon ketone, representing the prima nucleus of the structure. They have been classified, according to chemical structures, in Licochalcone A, B, C, D, E, F and G. This review aims to highlight all the in vitro and in vivo studies that have been conducted on the licochalcones, extracted from Glycyrrhiza species. The main effects are as follows: anti-inflammatory, antioxidant, anticancer, antimicrobial, antiviral, antiallergic, antidiabetic, hepatotoxic and osteogenic. It is important to implement the introduction of biologically active natural molecules from the bench (research) to the bedside (clinical practice). However, in the future, it is required to conduct additional studies to validate these biological effects.
Preparation and Antitubercular Activities of Palindromic Hydrazinecarbothioamides and Carbonothioic Dihydrazides
Authors: Hearn Michael Joseps , Towers Gwendolyn , Cynamon Michael Henry
Published: July 2018

Background:

With approximately one-third of the world’s population infected, tuberculosis continues to be a global public health crisis. The rise of strains that are unusually virulent or highly resistant to current drugs is a cause of special concern, prompting research into new classes of compounds, as well as the re-evaluation of known chemotherapeutic agents.

Objectives:

The antimycobacterial activities associated with some recently-reported thiocarbonyl compounds kindled our interest in the synthesis of substituted hydrazinecarbothioamides (3) and carbonothioic dihydrazides (4), with the aim of investigating their potential in antitubercular drug design and discovery.

Methods:

In the present study, the title compounds 3 and 4 were prepared by the condensation of hydrazines with isothiocyanates in reactions readily controlled by stoichiometry, temperature and solvent. The compounds were assessed against Mycobacterium bovis BCG in Kirby-Bauer disc diffusion, and minimum inhibitory concentrations were determined against the virulent strain M. tuberculosis Erdman.

Results:

The chemical structures of these thermally stable compounds were determined by IR, 1HNMR, 13C-NMR, high-resolution mass spectrometry and elemental analysis. In the Kirby-Bauer disc diffusion assay, some of the compounds showed substantial diameters of inhibition against BCG. In some cases, the zones of inhibition were so large that no growth at all was observed on the assay plates. Against M. tuberculosis Erdman, several of the compounds showed significant activities. Compound 3h was the most active, demonstrating a minimum inhibitory concentration of 0.5 µg/mL.

Conclusion:

We found that the title compounds may be prepared conveniently in excellent purity and good yields. They are readily identified on the basis of their characteristic spectra. Some members of this class showed significant activities against mycobacteria. We conclude that further work will be warranted in exploring the antitubercular properties of these compounds.
Exploring the Potential Bioactive Properties of Marine Natural Products
Authors: Zarena Arasali S.
Published: July 2018

Background:

The marine world is highly diversified and is of great importance for its sustainable
utilization as resources for human life. Although marine resource economy has its own share in
the international market, there is only a handful of research occurring, the probability of not being completely
explored. It has now become virtually possible to characterize the metabolites by bioanalytical
techniques and molecular biology methodology. The marine biomes harbour largely diatoms, bacteria,
fungi, actinomycetes, and cyanobacteria that are harnessed for their rich structurally diverse secondary
metabolites. Recently, sponges and algae have gained commercial importance. Focuses are now shifting
towards ascomycota, actinobacteria, cyanobacteria and other classes due to the advanced technology in
extraction of the active components from these phyla and deeper exploration of the oceans.

Method:

A vast report on marine natural products have been regularly updated and published which
clearly indicates the immense research undertaken in ocean flora and fauna. Herein we focus on providing
information on the potential uses of marine natural products as bioactive agents in the last five years.
The data were collected from research and review articles from peer-reviewed journals.

Results:

A total of 128 articles are citied in the present review covering broad spectrum of marine organism
and their importance in the field of medical biology. Information on source organisms, collection
sites, was assembled and a total of 120 biologically important compounds are described here.

Conclusion:

The present study provides information to bioprospecting efforts in the field of marine
science. Herein, I have emphasized diverse biological activities isolated from marine microbes to invertebrate
against many pathogenic microorganisms and cancer, thus making marine-derived natural products
valuable commodities. Future prospects for the discovery of new marine products and process development
could add to the economic importance.
Nanoparticles as Therapeutic Delivery Systems in Relation to Cancer Diagnosis and Therapy
Authors: Dastmalchi Narges , Safaralizadeh Reza , Latifi-Navid Saeid
Published: July 2018

Background:

In recent years, nanotechnology has been known as an integrated knowledge collection which involves various fields. One of the developing fields of nanotechnology which has achieved significant approval is named nanobiotechnology. Nanobiotechnology is a combined form of biology and nanotechnology that incorporates the synthesis of nanoparticles(NPs) that are less than 100nm in size and have following use in biological applications.

Objective:

The present review study is focused on the variety of nanocarriers and their use in biomedicine and tumor diagnosis and treatment.

Results:

Conventional therapeutic drugs have exhibited substantial limitations. Therefore, significant attainments have efficiently been made in nanobiotechnology for delivering drugs to the position of action, and reducing their side-effects and limiting radiation therapy toward tumorous sites. So far, several polymeric nanocarriers integrating cytotoxic therapeutics have been made. There is a need for modulation of size and surface features of NPs because unchanged NPs are cleaned from blood circulation. In order to increase biological distribution of therapeutic drugs, irradiation effect, and better tumor imaging, several modified nanocarriers have been developed in optimum size as well as altered external part.

Conclusion:

In this way, NP is known as an efficient and alternative approach for various aims, including drug delivery, PTT, gene therapy, imaging and diagnosis. There is an anticipation about the contribution of NPs in the field of efficient cancer treatment. Furthermore, NPs may be a proper approach in the treatment of other diseases such as HIV/AIDS. The present review focuses on the variety of nanocarriers and their use in biomedicine and tumor diagnosis and treatment.
Assessment of Physiological Equivalent Temperature (PET) in Transitional Spaces of a High-Rise Building
Authors: Taib Nooriati
Published: July 2018

One passive approach that can significantly reduce energy usage in high-rise buildings is through the creation of non-air conditioned spaces such as transitional spaces. Optimizing passive design would reduce wastage associated with the building’s energy consumption. The study measures the thermal comfort of three types of transitional spaces (sky court, balcony, and rooftop) in a high-rise office building. Based on the assessment of Physiological Equivalent Temperature (PET), the outcome showed significant differences in PET in all locations in both wet and dry season. The effectiveness of such area can be improved with the contributions of landscape, maximizing natural ventilation and day lighting where possible.Keywords: Thermal comfort; transitional spaces; high-rise; Physiological Equivalent TemperatureeISSN 2398-4295 © 2018. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
The Influential Factors of Successful Public Parks in Malaysia
Authors: Md Sakip Siti Rasidah , Mt Akhir Norizan , Omar Siti Syamimi
Published: July 2018

The main factors that contribute in successful of the park are good of access and linkage (GAL), degree of comfort and image (DCI), user and activities (UAC) and sociability (SOC). Six public park in Malaysia involved in this study conducted through a survey using a questionnaire. The validation and reliability of four constructs were done using Cronbach’s Alpha. The result found that all construct achieved Cronbach’s Alpha coefficient level exceeding 0.60 (GAL=0.89, DCI=0.82, UAC=0.82, SOC=0.82). These results explain all items in GAL, DCI, UAC and SOC construct have good internal consistency, indicating that all dimensions have a good reliability value.Keywords: public park, perception, accessibility, lingkageseISSN 2398-4295 © 2018. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
Пріоритетні напрями хірургічного лікування поранених з ушкодженням периферичних нервів верхньої кінцівки при поліструктурних травмах
Authors: Strafun S.S. , Borzykh N.O. , Haiko O.G. , Borzykh O.V. , Gayovich V.V. , Tsymbaliuk Ya.V.
Published: July 2018

Актуальність. Стаття присвячена тактиці хірургічного лікування постраждалих з ушкодженням периферичних нервів унаслідок вогнепальних поліструктурних поранень верхньої кінцівки. Визначено, що особливістю вогнепальних ушкоджень нервів є нерівномірність ураження в різних ділянках або на декількох рівнях у різних анатомічних ділянках, що диктує персоніфіковані підходи до лікування. Метою дослідження було удосконалення хірургічної тактики лікування поранених з ушкодженням периферичних нервів унаслідок вогнепальних поліструктурних ушкоджень верхніх кінцівок. Матеріали та методи. Проаналізовані результати хірургічного лікування 202 поранених з ушкодженням периферичних нервів унаслідок вогнепальних поліструктурних ушкоджень верхніх кінцівок. Результати. Важливими аспектами у лікуванні таких пацієнтів є: обов’язкова стабілізація кісткових уламків при вогнепальному переломі перед відновленням нерва, адекватне заміщення м’якотканинних дефектів, що відкриває можливості для створення сприятливих умов оточення ушкодженого нерва та стимуляції регенерації останнього з відновленням тканини «ковзання». Висновки. Своєчасне, раннє відновлення периферичних нервів, яке виконувалось одночасно з остеосинтезом та заміщенням дефекту тканин, дозволяє отримати раннє відновлення функції верхньої кінцівки.
Взаємозв’язок сироваткового вмісту цитокінів і нейропептидів у дітей з рекурентним бронхітом і синдромом вертебробазилярної артеріальної системи
Authors: Ovcharenko L.S. , Slutska T.V.
Published: July 2018

Актуальність. Наявність дисбалансу нервової регуляції у дітей зумовлює тяжкий клінічний перебіг бронхолегеневої патології. Вивчення нейроімунних взає­мин у дітей з синдромом вертебробазилярної артеріальної системи і гострими бронхітами дозволить встановити важливі елементи патогенезу даної комбінації. Мета дослідження: визначення нейроімунних взаємин у дітей з синдромом вертебробазилярної артеріальної системи, що сприяють формуванню частих повторних (рекурентних) гострих бронхітів. Матеріали та методи. Під спостереженням знаходилося 60 дітей віком від 7 до 12 років. Сформовано 2 групи спостереження (по 30 дітей у кожній): 1) діти з синдромом вертебробазилярної артеріальної системи, які хворіють на гострий бронхіт; 2) діти без синдрому вертебробазилярної артеріальної системи, які хворіють на гострий бронхіт. Результати. У дітей 1-ї групи порівняно з дітьми 2-ї групи частіше реєструється зниження фагоцитарного числа (на 56,7 %; р < 0,05), фагоцитарного індексу (на 53,3 %; р < 0,05), індексу завершеності фагоцитозу (на 66,7 %; р < 0,05), стимульованого НСТ-тесту (на 40 %; р < 0,05). При дослідженні адаптивного імунітету виявлено збільшення кількості дітей 1-ї групи з підвищеним вмістом в крові CD3+ (на 40 %; р < 0,05), CD4+ (на 33,4 %; р < 0,05), CD8+ (на 46,7 %; р < 0,05), CD25+ (на 83,3 %; р < 0,05), збільшенням в сироватці крові концентрації IgG (на 33,3 %; р < 0,05) і IgМ (на 54,3 %; р < 0,05) на тлі зниження IgА (на 40 %; р < 0,05). У дітей 1-ї групи частіше реєструвався підвищений вміст в сироватці крові фактора некрозу пухлини a (на 70 %; р < 0,05) і зниження інтерлейкіну 10 (на 40 %; р < 0,05) одночасно зі збільшенням концентрації субстанції Р (на 40 %; р < 0,05) і зниженням вазоактивного інтестинального пептиду (на 30 %; р < 0,05). Висновки. У дітей з синдромом вертебробазилярної артеріальної системи, які хворіють на гострі бронхіти, має місце переважання в сироватці крові прозапальних цитокінів і нейропептидів з недостатністю протизапальних.
Скринінг бронхіальної астми як ефективний метод вчасного її виявлення у дітей шкільного віку
Authors: Fedortsiv O.Ye. , Volyanska L.A. , Burbela E.I. , Pospikh N.Yu.
Published: July 2018

Проведене епідеміологічне дослідження бронхіальної астми шляхом анкетування батьків і дітей міської та сільської місцевості Тернопільської області з метою вивчення поширеності, визначення та репрезентації основних маркерів захворюваності серед дітей старшого та середнього шкільного віку. Дітям проводилися детальний збір анамнезу, анкетне опитування, розроблене згідно з методологією ISAAC, та об’єктивне клінічне обстеження. Даний фрагмент епідеміологічних досліджень засвідчив, що показники поширення бронхообструктивних захворювань у регіоні (5,62 %) суттєво відрізняються від показників офіційної статистики (1,7 %).
Застосування лікувально-профілактичного комплексу при карієсі та гінгівіті у дітей шкільного віку
Authors: Trubka I.A.
Published: July 2018

Актуальність. Єдність найбільш значущих патогенетичних механізмів розвитку карієсу та захворювань тканин пародонту обґрунтовує сучасну концепцію профілактики цих захворювань, що включає розробку лікувально-профілактичних програм з урахуванням клінічних особливостей поєднаного перебігу карієсу та захворювань пародонту в дітей та основних патогенетичних механізмів розвитку цих захворювань. Мета дослідження: оцінити вплив розробленого лікувально-профілактичного комплексу в дітей шкільного віку при поєднаному перебігу карієсу та хронічного катарального гінгівіту з урахуванням основних патогенетичних механізмів розвитку цих захворювань. Матеріали та методи. Клінічні дослідження проводили за участю 138 дітей віком від 7 до 10 років, у яких визначали індекс кп + КПУ, приріст інтенсивності карієсу зубів, редукцію та карієспрофілактичний ефект, ТЕР-тест, індекс Greenn — Wermillion, спрощений індекс зубного нальоту О’Leary, індекс ефективності гігієни порожнини рота (РНР), індекс РМА, Basic Periodontal Examination-Simplified (BPES) перед проведенням лікувально-профілактичного комплексу (ЛПК) та через 18 місяців після його триразового застосування. Результати. Результати клінічного дослідження показали, що при позитивній динаміці клінічних показників у дітей всіх досліджуваних груп, у підгрупах, де ми застосовували розроблений і запропонований ЛПК, ми визначили добрий стан гігієни порожнини рота (0,37 ± 0,03; 0,46 ± 0,04) та добру ефективність проведення гігієнічних заходів (0,58 ± 0,05; 0,60 ± 0,03); низький рівень приросту інтенсивності карієсу (0,11–0,18) із редукцією 67,27–80,70 % при карієспрофілактичній ефективності 66,53–76,79 % на відміну від контрольних груп дітей, в яких рівень приросту інтенсивності карієсу становив 0,35–0,57, гігієнічний стан порожнини рота залишився на задовільному рівні. Серед дітей із хронічним катаральним гінгівітом повне усунення основних клінічних ознак запалення з подальшою довготривалою ремісією при застосуванні ЛПК ми спостерігали в більшому відсотку випадків на відміну від дітей, при лікуванні яких використовували стандартні підходи. Висновки. Отримані результати клінічних досліджень, а саме запобігання подальшому розвитку карієсу та усунення основних клінічних проявів запалення ясен із тривалою ремісією, свідчать про позитивний вплив та ефективність розробленого ЛПК.