bluuebunny/crossref_metadata_2025 huggingface dataset:
The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT / Cyclin D signaling
Authors: Zhang He , Zhang Li-Qun , Yang Cheng-Cheng , Li Jin , Tian Xin-Yuan , Li Dan-Ni , Cui Ju , Cai Jian-Ping
Published: February 2021

NUDIX hydrolase type 5 (NUDT5) is a kind of ADP-ribose pyrophosphatase and nucleotide metabolizing enzyme in cell metabolism. Previous studies have shown NUDT5 expression affected chromosome remodeling, involved in cell adhesion, cancer stem cell maintenance and epithelial to mesenchyme transition in breast cancer cells. Nevertheless, the role of NUDT5 in breast cancer progression and prognosis has not yet been systematically studied. This study explored the association of NUDT5 with the tumor development and poor prognosis in patients with breast cancer. Our results show that the levels of NUDT5 were upregulated in breast cancer cell lines and breast tumor tissues, and the expression of NUDT5 in breast tumor tissues increased significantly when compared with adjacent non-tumorous tissues by immunohistochemical staining of tissue microarrays. Breast cancer patients with high NUDT5 expression had a worse prognosis than those with low expression of NUDT5. In addition, the knockdown of NUDT5 suppressed breast cancer cell lines proliferation, migration and invasion, and dramatically inhibited the AKT phosphorylation at Thr308 and expression of Cyclin D1. The opposite effects were observed in vitro following NUDT5 rescue. Our findings indicated that the high expression of NUDT5 is probably involved in the poor prognosis of breast cancer via the activation of the AKT / Cyclin D pathways, which could be a prognostic factor and potential target in the diagnosis and treatment of breast cancer.
Context dependency in risky decision making: Is there a description-experience gap?
Authors: Park Inkyung , Windschitl Paul D. , Smith Andrew R. , Rule Shanon , Scherer Aaron M. , Stuart Jillian O.
Published: February 2021

When making decisions involving risk, people may learn about the risk from descriptions or from experience. The description-experience gap refers to the difference in decision patterns driven by this discrepancy in learning format. Across two experiments, we investigated whether learning from description versus experience differentially affects the direction and the magnitude of a context effect in risky decision making. In Study 1 and 2, a computerized game called the Decisions about Risk Task (DART) was used to measure people’s risk-taking tendencies toward hazard stimuli that exploded probabilistically. The rate at which a context hazard caused harm was manipulated, while the rate at which a focal hazard caused harm was held constant. The format by which this information was learned was also manipulated; it was learned primarily by experience or by description. The results revealed that participants’ behavior toward the focal hazard varied depending on what they had learned about the context hazard. Specifically, there were contrast effects in which participants were more likely to choose a risky behavior toward the focal hazard when the harm rate posed by the context hazard was high rather than low. Critically, these contrast effects were of similar strength irrespective of whether the risk information was learned from experience or description. Participants’ verbal assessments of risk likelihood also showed contrast effects, irrespective of learning format. Although risk information about a context hazard in DART does nothing to affect the objective expected value of risky versus safe behaviors toward focal hazards, it did affect participants’ perceptions and behaviors—regardless of whether the information was learned from description or experience. Our findings suggest that context has a broad-based role in how people assess and make decisions about hazards.
Running behaviors, motivations, and injury risk during the COVID-19 pandemic: A survey of 1147 runners
Authors: DeJong Alexandra F. , Fish Pamela N. , Hertel Jay
Published: February 2021

The COVID-19 pandemic has influenced activity behaviors worldwide. Given the accessibility of running as exercise, gaining information on running behaviors, motivations, and running-related injury (RRI) risk during the pandemic is warranted. The purpose of this study was to assess the influence of the COVID-19 pandemic on running volume, behaviors, motives, and RRI changes from the year prior to the pandemic to the timeframe during social isolation restrictions. Runners of all abilities were recruited via social media to complete a custom Qualtrics survey. Demographics, running volume, behaviors, motivations, and injury status were assessed for the year prior to the pandemic, and during social isolation measures. Descriptive statistics and Student’s t-tests were used to assess changes in running outcomes during the pandemic. Logistic regressions were used to assess the influence of demographics on running behaviors and injury. Adjusted RRI risk ratios were calculated to determine the odds of sustaining an injury during the pandemic. Alpha was set to.05 for all analyses. A total of 1147 runners (66% females, median age: 35 years) across 15 countries (96% United States) completed the survey. Runners reported increased runs per week (Mean Difference with Standard Error [MD]: 0.30 [0.05], p < .001), sustained runs (MD: 0.44 [0.05], p < .001), mileage (MD: 0.87 [0.33], p = .01), and running times of day (MD: 0.11 [0.03], p < .001) during the pandemic, yet reported less workouts (i.e. sprint intervals; MD: -0.33 [0.06], p < .001), and less motives (MD [SE]: -0.41 [0.04], p < .001). Behavior changes were influenced by running experience and age. There was 1.40 (CI: 1.18,1.61) times the RRI risk during the pandemic compared to prior to the social isolation period. The COVID-19 pandemic influenced runners’ behaviors with increased training volume, decreased intensity and motivation, and heightened injury risk. These results provide insights into how physical activity patterns were influenced by large-scale social isolation directives associated with the pandemic.
Associations between smoking trajectories, smoke-free laws and cigarette taxes in a longitudinal sample of youth and young adults
Authors: Apollonio Dorie E. , Dutra Lauren M. , Glantz Stanton A.
Published: February 2021

Cigarette smoking patterns vary within the population, with some individuals remaining never smokers, some remaining occasional users, and others progressing to daily use or quitting. There is little research on how population-level tobacco control policy interventions affect individuals within different smoking trajectories. We identified associations between tobacco control policy interventions and changes across different smoking trajectories among adolescents and young adults. Using 15 annual waves of data drawn from the National Longitudinal Survey of Youth 1997 (NLSY97), we applied a group-based trajectory model to identify associations between days smoked per month, comprehensive smoke-free laws, cigarette tax rates, and known socio-demographic risk factors for membership in different smoking trajectories. Comprehensive smoke-free laws were associated with reduced risk of initiation and reductions in days smoked per month for all trajectories other than occasional users. Higher tax rates were associated with reduced risk of initiation and days smoked for all trajectories other than established users. Overall, population-based tobacco control policies, particularly comprehensive smoke-free laws, were associated with reduced smoking. Tobacco taxes primarily reduced risk of initiation and use among never smokers, experimenters, and quitters, consistent with previous research suggesting that tobacco manufacturers lower prices after tax increases to reduce the cost of continued smoking for established users. These results provide support for expanding smoke-free laws and establishing a minimum tobacco floor price, which could improve public health by reducing the risk of initiation as well as use among occasional and established smokers.
Early dynamic changes in circulating tumor cells and prognostic relevance following interventional radiological treatments in patients with hepatocellular carcinoma
Authors: Vogl Thomas J. , Riegelbauer Linda J. , Oppermann Elsie , Kostantin Michel , Ackermann Hanns , Trzmiel Annette , Stein Stefan , Eichler Katrin , Zharov Vladimir P. , Roy Dhruvajyoti , Schnitzbauer Andreas A. , Strücker Benjamin , Pascher Andreas , Bechstein Wolf O. , Juratli Mazen A.
Published: February 2021

The aim of this study was to investigate the dynamic changes of circulating tumor cells (CTCs) in patients with hepatocellular carcinoma (HCC) before and immediately after conducting a microwave ablation (MWA) and conventional transarterial chemoembolization (C-TACE). Additionally, the CTCs short-term dynamics were compared with the clinical course of the HCC-patients. Blood samples from 17 patients with HCC who underwent MWA (n = 10) or C-TACE (n = 7) were analyzed. Venous blood was taken before and immediately after the radiological interventions to isolate and quantify CTCs using flow cytometry. CTCs were identified as CD45- and positive for the markers ASGPR, CD146 and CD274 (PD-L1). Patients were followed of up to 2.2 years after the radiological intervention. CTCs were detected in 13 HCC patients (76%) prior to the radiological interventions. The rate of CTCs was significantly decreased after the intervention in patients treated with MWA (0.4 CTCs/mL of blood, p = 0.031). However, no significant differences were observed in patients who received C-TACE (0.3 CTCs/mL of blood, p = 0.300). Overall, no correlation was found between the CTCs rate before and after the radiological intervention and recurrence rate of HCC. This preliminary data could confirm the tumoricidal effects of MWA in patients with HCC by significantly decreasing CTCs rate. In our study, we were able to detect CTCs in HCC patients using 3 different tumor markers. This preliminary data shows significant lower CTCs detected in response to MWA. However, large-scale randomized clinical trials are needed to determine the future role and the prognostic relevance of CTCs following this treatment.
Improved cancer biomarkers identification using network-constrained infinite latent feature selection
Authors: Cai Lihua , Wu Honglong , Zhou Ke
Published: February 2021

Identifying biomarkers that are associated with different types of cancer is an important goal in the field of bioinformatics. Different researcher groups have analyzed the expression profiles of many genes and found some certain genetic patterns that can promote the improvement of targeted therapies, but the significance of some genes is still ambiguous. More reliable and effective biomarkers identification methods are then needed to detect candidate cancer-related genes. In this paper, we proposed a novel method that combines the infinite latent feature selection (ILFS) method with the functional interaction (FIs) network to rank the biomarkers. We applied the proposed method to the expression data of five cancer types. The experiments indicated that our network-constrained ILFS (NCILFS) provides an improved prediction of the diagnosis of the samples and locates many more known oncogenes than the original ILFS and some other existing methods. We also performed functional enrichment analysis by inspecting the over-represented gene ontology (GO) biological process (BP) terms and applying the gene set enrichment analysis (GSEA) method on selected biomarkers for each feature selection method. The enrichments analysis reports show that our network-constraint ILFS can produce more biologically significant gene sets than other methods. The results suggest that network-constrained ILFS can identify cancer-related genes with a higher discriminative power and biological significance.
Total plaque score helps to determine follow-up strategy for carotid artery stenosis progression in head and neck cancer patients after radiation therapy
Authors: Liu Chi-Hung , Chang Joseph Tung-Chieh , Lee Tsong-Hai , Chang Pi-Yueh , Chang Chien-Hung , Wu Hsiu-Chuan , Chang Ting-Yu , Huang Kuo-Lun , Lin Chien-Yu , Fan Kang-Hsing , Chu Chan-Lin , Chang Yeu-Jhy
Published: February 2021

Background

To identify predictors of carotid artery stenosis (CAS) progression in head and neck cancer (HNC) patients after radiation therapy (RT).

Methods

We included 217 stroke-naïve HNC patients with mild carotid artery stenosis after RT in our hospital. These patients underwent annual carotid duplex ultrasound (CDU) studies to monitor CAS progression. CAS progression was defined as the presence of ≥50% stenosis of the internal/common carotid artery on follow-up CDU. We recorded total plaque score (TPS) and determined the cut-off TPS to predict CAS progression. We categorized patients into high (HP) and low plaque (LP) score groups based on their TPS at enrolment. We analyzed the cumulative events of CAS progression in the two groups.

Results

The TPS of the CDU study at enrolment was a significant predictor for CAS progression (adjusted odds ratio [aOR] = 1.69, p = 0.002). The cut-off TPS was 7 (area under the curve: 0.800), and a TPS ≥ 7 strongly predicted upcoming CAS progression (aOR = 41.106, p = 0.002). The HP group had a higher risk of CAS progression during follow-up (adjusted hazard ratio = 6.15; 95% confident interval: 2.29–16.53) in multivariable Cox analysis, and also a higher trend of upcoming ischemic stroke (HP vs. LP: 8.3% vs. 2.2%, p = 0.09).

Conclusions

HNC patients with a TPS ≥ 7 in any CDU study after RT are susceptible to CAS progression and should receive close monitoring within the following 2 years.
Can we detect conditioned variation in political speech? two kinds of discussion and types of conversation
Authors: Sloman Sabina J. , Oppenheimer Daniel M. , DeDeo Simon
Published: February 2021

Previous work has demonstrated that certain speech patterns vary systematically between sociodemographic groups, so that in some cases the way a person speaks is a valid cue to group membership. Our work addresses whether or not participants use these linguistic cues when assessing a speaker’s likely political identity. We use a database of speeches by U.S. Congressional representatives to isolate words that are statistically diagnostic of a speaker’s party identity. In a series of four studies, we demonstrate that participants’ judgments track variation in word usage between the two parties more often than chance, and that this effect persists even when potentially interfering cues such as the meaning of the word are controlled for. Our results are consistent with a body of literature suggesting that humans’ language-related judgments reflect the statistical distributions of our environment.
Development of a time-resolved mirrorless scintillation detector
Authors: Cheon Wonjoong , Jung Hyunuk , Lee Moonhee , Lee Jinhyeop , Kim Sung Jin , Cho Sungkoo , Han Youngyih
Published: February 2021

Purpose

We developed a compact and lightweight time-resolved mirrorless scintillation detector (TRMLSD) employing image processing techniques and a convolutional neural network (CNN) for high-resolution two-dimensional (2D) dosimetry.

Methods

The TRMLSD comprises a camera and an inorganic scintillator plate without a mirror. The camera was installed at a certain angle from the horizontal plane to collect scintillation from the scintillator plate. The geometric distortion due to the absence of a mirror and camera lens was corrected using a projective transform. Variations in brightness due to the distance between the image sensor and each point on the scintillator plate and the inhomogeneity of the material constituting the scintillator were corrected using a 20.0 × 20.0 cm2 radiation field. Hot pixels were removed using a frame-based noise-reduction technique. Finally, a CNN-based 2D dose distribution deconvolution model was applied to compensate for the dose error in the penumbra region and a lack of backscatter. The linearity, reproducibility, dose rate dependency, and dose profile were tested for a 6 MV X-ray beam to verify dosimeter characteristics. Gamma analysis was performed for two simple and 10 clinical intensity-modulated radiation therapy (IMRT) plans.

Results

The dose linearity with brightness ranging from 0.0 cGy to 200.0 cGy was 0.9998 (R-squared value), and the root-mean-square error value was 1.010. For five consecutive measurements, the reproducibility was within 3% error, and the dose rate dependency was within 1%. The depth dose distribution and lateral dose profile coincided with the ionization chamber data with a 1% mean error. In 2D dosimetry for IMRT plans, the mean gamma passing rates with a 3%/3 mm gamma criterion for the two simple and ten clinical IMRT plans were 96.77% and 95.75%, respectively.

Conclusion

The verified accuracy and time-resolved characteristics of the dosimeter may be useful for the quality assurance of machines and patient-specific quality assurance for clinical step-and-shoot IMRT plans.
Could social interaction reduce the disposition effect? Evidence from retail investors in a directed social trading network
Authors: Jin Xuejun , Li Rui , Zhu Yu
Published: February 2021

With data collected from a directed social trading network, this paper investigates how social interaction affects the disposition effect. We constantly observe a negative association between them: After being exposed to social interaction, a trader’s odds ratio to sell a paper gain stock decreases by 9% to 10%, depending on different model settings. We then test the mechanisms of social interaction by decomposing it into three channels: learning intensity (willingness to learn), learning quality (information advantage through learning), and public scrutinization (exposure of trading outcome to others). We find that all three channels contribute to a smaller disposition effect. Specifically, our findings support the claim that public scrutinization promotes self-consciousness and reduces disposition effect. Also, our results extend previous studies on investors’ information advantage by suggesting that it could also help to mitigate the disposition effect through the reduction of uncertainty. Overall, this paper suggests a positive role of social trading platforms in helping investors make better decisions.
Chemical characterization and in vitro immunomodulatory effects of different extracts of moss Hedwigia ciliata (Hedw.) P. Beauv. from the Vršačke Planine Mts., Serbia
Authors: Mandić Marija R. , Oalđe Mariana M. , Lunić Tanja M. , Sabovljević Aneta D. , Sabovljević Marko S. , Gašić Uroš M. , Duletić-Laušević Sonja N. , Božić Bojan Dj. , Božić Nedeljković Biljana Dj.
Published: February 2021

Bioactive compounds from natural sources are of great importance because of their potential pharmacological activity and tremendous structural diversity. In this study, the chemical composition of different moss extracts ofHedwigia ciliataP. Beauv. have been examined, as well as their antioxidant, antineurodegenerative/anti-neuroinflammatory, antidiabetic, and antiproliferative potential. The extracts were prepared by Soxhlet extractor using solvents of different polarity. Chemical characterization of the extracts revealed the presence of phenolics and flavonoid compounds, together with triterpenoids as secondary metabolites of high biological activity. Significant antioxidant properties of all the extracts were exhibited using the β-carotene assay. The highest activities were found for water:ethanol extract (with the highest inhibition rate of 96%), but also significant inhibition was measured for ethanol and ethyl acetate extracts (80% and 70%, respectively). Confirmation of biocompatibility of investigated moss extracts has been performed using normal human fibroblast cell line, MRC-5. TheH.ciliataextracts exhibited significant antiproliferative activity (~ 50%) against the MDA-MB-231 (human breast adenocarcinoma cell line), which has not previously been reported elsewhere. The Griess assay confirmed the potential anti-neuroinflammatory activity of the extracts, as significant effects in reducing NO production by LPS-stimulated BV2 (normal murine microglia cell line) was observed. This data is in line with noted antineurodegenerative potential measured by the inhibition of acetylcholinesterase (with the highest inhibition rate of 60% for ethyl acetate extract) and tyrosinase (with the highest inhibition rate of 70% for ethanol extract). Additionally, theH.ciliataextracts exhibited significant antidiabetic effect mediated by α-glucosidase inhibition (with the highest inhibition rate of 80% for ethyl acetate extract). The obtained data suggest the presence of immunomodulatory effects of the moss extractsin vitro, which allows the design of new experiments aimed at detecting and characterizing bioactive compounds of the extracts and additionally elucidate detailed mechanisms of their effects.
Early detection of neutralizing antibodies against SARS-CoV-2 in COVID-19 patients in Thailand
Authors: Putcharoen Opass , Wacharapluesadee Supaporn , Chia Wan Ni , Paitoonpong Leilani , Tan Chee Wah , Suwanpimolkul Gompol , Jantarabenjakul Watsamon , Ruchisrisarod Chanida , Wanthong Phanni , Sophonphan Jiratchaya , Chariyavilaskul Pajaree , Wang Lin-Fa , Hemachudha Thiravat
Published: February 2021

Background

The presence of neutralizing antibodies (NAbs) is an indicator of protective immunity for most viral infections. A newly developed surrogate viral neutralization assay (sVNT) offers the ability to detect total receptor binding domain-targeting NAbs in an isotype-independent manner, increasing the test sensitivity. Thus, specimens with low IgM/ IgG antibody levels showed strong neutralization activity in sVNT.

Methods

This study aimed to measure the %inhibition of NAbs measured by sVNT in PCR-confirmed COVID-19 patients. The sensitivity of sVNT for the diagnosis of SARS-CoV-2 infection and its kinetics were determined.

Results

Ninety-seven patients with PCR-confirmed SARS-CoV-2 infection were included in this study. Majority of the patients were 21–40 years old (67%) and 63% had mild symptoms. The sensitivity of sVNT for the diagnosis of SARS-CoV-2 infection was 99% (95% confidence interval (CI) 94.4–100%) and the specificity was 100% (95% CI 98.3–100%). The negative predictive value of sVNT from the samples collected before and after 7 days of symptom onset was 99.5% (95% CI 97.4–100%) and 100% (95% CI 93.8–100%), respectively. The level of inhibition at days 8–14 were significantly higher than days 0–7 (p<0.001). The median %inhibition values by severity of COVID-19 symptoms were 79.9% (interquartile range (IQR) 49.7–91.8%); 89.0% (IQR 71.2–92.4%); and 86.6% (IQR 69.5–92.8%), for mild, moderate and severe/critical symptoms respectively. The median level of sVNT %inhibition of severe was significantly higher than the mild group (p = 0.05).

Conclusion

The sVNT is a practical and robust serological test for SARS-CoV-2 infection and does not require specialized biosafety containment. It can be used clinically to aid diagnosis in both early and late infection especially in cases when the real-time RT-PCR results in weakly negative or weakly positive, and to determine the protective immune response from SARS-CoV-2 infection in patients.
Serum levels of anti-PspA and anti-PspC IgG decrease with age and do not correlate with susceptibility to experimental human pneumococcal colonization
Authors: Araujo Adriano P. , Colichio Gabriela B. C. , Oliveira Maria Leonor S. , German Esther , Nikolaou Elissavet , Chen Tao , Adler Hugh , Ferreira Daniela M. , Miyaji Eliane N.
Published: February 2021

Older adults are at increased risk of pneumococcal disease. This work aims to evaluate whether there is any decrease in serum IgG against variants of the antigens Pneumococcal surface protein A (PspA) and Pneumococcal surface protein C (PspC) in healthy adults with increasing age. Levels of IgG against PspA and PspC variants were determined by ELISA in serum samples comparing volunteers 18–30 years of age with volunteers who were 50–70+ before and after an experimental pneumococcal colonization challenge. The serotype 6B strain used in the challenge belongs to a minor group of pneumococcal isolates expressing two PspC variants. There was a decrease in levels of IgG with increasing age for the most common PspA variants and for all PspC variants analyzed. No correlation was found between basal levels of IgG against these antigens and protection against colonization. There was an increase in levels of IgG against PspA variants that are more cross-reactive with the variant expressed by the challenge strain post challenge in younger individuals who became colonized. Since the challenge strain used in our study expresses two different PspC variants, an increase in serum IgG against all PspC variants tested was observed in younger individuals who became colonized. For some of the antigen variants tested, a decrease in serum IgG was observed in young volunteers who were challenged but did not become colonized. Serum IgG antibodies against PspA and PspC variants thus decrease with age in healthy adults, but there is no correlation between levels of IgG against these antigens and protection against human experimental colonization. Though no correlation between naturally induced serum IgG antibodies against PspA and PspC and protection against colonization was observed, these results do not rule out the protective potential of these antigens as vaccines against pneumococcal infections.
Transocular sonography in acute arterial occlusions of the eye in elderly patients: Diagnostic value of the spot sign
Authors: Czihal Michael , Lottspeich Christian , Köhler Anton , Prearo Ilaria , Hoffmann Ulrich , Priglinger Siegfried G. , Mackert Marc J.
Published: February 2021

Purpose

To characterize the diagnostic yield of the spot sign in the diagnostic workup of acute arterial occlusions of the eye in elderly patients.

Methods

Clinical characteristics of consecutive patients aged ≥ 50 years with acute central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) or anterior ischemic optic neuropathy (AION) were recorded. Videos of transocular sonography were assessed for the presence of the spot sign by two blinded readers. Group comparisons were made between CRAO-patients with and without the spot sign. Two experienced cardiovascular physicians allocated CRAO-cases to a presumed aetiology, without and with knowledge on the presence/absence of the spot sign.

Results

One-hundred-twenty-three patients were included, 46 of whom suffered from CRAO. A spot sign was seen in 32 of 46 of patients with CRAO and in 7 of 23 patients with BRAO. Interobserver agreement was excellent (Cohen`s kappa 0.98). CRAO-patients with the spot sign significantly more frequently had a medical history of cardiovascular disease (62.8 vs. 21.4%, p = 0.03) and left heart valve pathologies (51.9 vs. 10%, p = 0.03). The spot sign was not found in any of the three patients with CRAO secondary to cranial giant cell arteritis. The assumed CRAO aetiology differed in 37% of cases between two cardiovascular physicians, regardless whether transocular sonography findings were known or not.

Conclusion

The spot sign is a simple sonographic finding with excellent interobserver agreement, which proofs the embolic nature of CRAO, but does not allow exact attribution of the underlying aetiology.
Nutritional education through recreational activities as an entertainment tool in Hotel businesses
Authors: Melo Priscila Fernandes Carvalho de , Mota Edilaine da Silva , Vieira Patrícia Pinheiro Fernandes
Published: February 2021

Food, with its different flavors, is introduced into a child’s life by the family and through nutritional education. Recreational activities also give children the ability to understand what to eat, and how to eat it. Due to the high demand for tourist accommodation that focuses on the family segment, the tourist trade, particularly hotel business, is hiring more employees in the recreation and leisure sector, in order to assist children and parents who want to enjoy a few hours of carefree leisure and rest. This article aims to show that recreational activities that provide nutritional education can be developed by hotel businesses as a form of children’s entertainment, stimulating creativity, teamwork, imagination, interpersonal relationships, the comfort of parents, along with an improvement in dietary habits. This study involves applied, exploratory, descriptive and bibliographic research, with a quantitative analysis to evaluate the level of children's satisfaction, using a visual 3-point Likert Scale. As an action strategy, we organized lectures with fun activities. We conclude that activities associated with nutritional learning are accepted by children as a means of socialization and entertainment, making them tools for use in accommodation establishments, as a recreational activity aimed at encouraging healthy eating.
P4TREE TECHNOLOGY APPLICATION AT THE BELO HORIZONTE CARNIVAL
Authors: Cruvinel Eduardo Henrique de Paula , Santos Idelaine Capanema da Cunha , Boffa Marcos Vinicius
Published: February 2021

The Brazilian Carnival is considered one of the best known tourist products internationally, and is responsible for the movement and composition of flows of people, motivation for travel, generation of income and jobs, changes in supply and demand and changes in consumption habits. The events surrounding the carnival also have social, cultural, economic, political and environmental impacts on the host cities. These impacts deserve attention, along with efforts to reduce the more negative ones. The Belo Horizonte Tourism Office - Belotur, an organization linked to the Belo Horizonte City Hall, in partnership with the Department of Chemistry of the Federal University of Minas Gerais – UFMG  introduced measures for the “P4Tree Technology Application at Belo Horizonte Carnival”. P4Tree is a technology developed at UFMG that consists of in the formulation of a tablet capable of holding the phosphorus element in contact with waste. This material is manipulated in the laboratory and transformed into fertilizer for use in various crops. This is because phosphorus is a fundamental nutrient for the development of any living being. The project was tested at the Belo Horizonte Carnival in 2018 and based on the results, it was replicated at the 2019 Carnival. It consisted of the application of P4Tree technology in 100 chemical toilets around the stage dedicated to the family and children’s programming of the Carnival, in the central region of Belo Horizonte, with high flow and movement of people. The toilets supplied and installed by Belotur were labeled with the project's visual identity, and were later equipped by the team of students from the UFMG Chemistry Department with P4Tree tablets in the tanks. The tablets were left in the toilets until the end of each day, before suction of the waste by the company responsible for cleaning the toilets. The P4Tree material collected was properly packaged and transferred to the University Laboratory where it was handled and made into fertilizer. This fertilizer was used/tested on five different crops at the Belo Horizonte Zoobotany Foundation, including Ipê, a tree symbol of Belo Horizonte. Tests were conducted to compare with traditional fertilizer used by the Zoobotany Foundation. The proposal is to use the seedlings of these crops to replant other areas of the city. Actions  to promote the use of technology that enables the sustainability to be incorporated at one of the biggest urban events in Belo Horizonte. Due to the visibility and results achieved, it can be replicated at events with different characteristics. Interdisciplinary combination relevant to the sector, considering events as one of the main links in the tourism production chain.
An integrated system for tourism destination management: reflections and proposal of a conceptual model from the perspective of hospitality
Authors: Santos Aristides Faria Lopes dos
Published: February 2021

This report presents the experience of the implementation of the “Tourism Observatory | SIGESTur” project, an action developed at the Federal Institute of São Paulo (IFSP Campus Cubatão). The project began in 2016, as result of academic research and university extension activity. This work reports and analyzes the results of the project, and proposes a model for innovative management of tourism destinations in the Brazilian context. In its first year, the project was considered one of the ten most innovative ideas in Brazilian tourism, at the I Tourism Innovation Camp, a contest promoted by the Panrotas portal with technical support from Sebrae (national development agency). In 2017, the case entitled “Hospitality and hostility relations among stakeholders: Influences in the competitiveness of tourist destinations” received an award during the IV World Research Summit for Tourism and Hospitality, a congress held in Orlando (USA). The project consists of two work fronts. For the elaboration of this report of experience, bibliographical and documentary research were carried out. The data analysis was done in 2019 to ensure that all previous actions were recorded. In the results, the establishment of a model is highlighted, for collecting, processing and analyzing data and distributing information to professionals in the travel and tourism industry.
Tourism in a small town: the Peabiru Way in the state of Paraná
Authors: Rocha Arléto Pereira , Silva Washington Luiz Henrique da
Published: February 2021

This is a case study on actions to generate jobs and income through historical, adventure, cultural and ecological tourism. Its purpose is to analyze the use of the repressed tourist potential of the ancient Caminhos de Peabiru, or Peabiru Way, a walking trail in the municipality of Peabiru, through the Projeto Caminhos de Peabiru: História, Cultura e Turismo (Peabiru Way Project: History, Culture and Tourism), which was started in 2016. The name of the town of Peabiru, in northwestern Paraná, is steeped in history, as it refers to the legendary Peabiru Way. Historical studies were carried out that led to the creation of the Peabiru Way Project. Hiking trails with varying levels of difficulty were mapped out along the course of the original trails of Peabiru, and taking in sights such as waterfalls, water mines, old buildings, mountains, valleys and rivers. These trails began to attract visitors to Peabiru; initially around ten or twenty visitors on weekends, with the numbers gradually increasing to as many as eight hundred visitors on one particular weekend. Nowadays, the region hosts visitors from the USA, Japan, Spain, Australia, and all over South America. As a result, local bakeries, restaurants, hotel, and gas stations have flourished, generating an increase in local commerce, while fulfilling the initial intentions of generating jobs, income and a sense of belonging and attracting tourists and income to the town. The work is justified by the fact that the Peabiru-PR is classed as a region of poverty, due to land concentration in the hands of a few, social and economic inequality, incipient industry and trade, and stagnant services. Tourism has emerged as a sector with good prospects for the region. Methodologically, this work is characterized as qualitative study, with a literature review of books, magazines and other materials, both printed and electronic, as well as the use of measured data in the application of the Peabiru Way Project in the town of Peabiru-PR. The next step is to train official guides, working voluntarily, with the aim of reducing the number of people, but increasing increase generation and income compared to today's huge flow. Today the Peabiru Way is visited by about one thousand people a month. The Associação Caminhos de Peabiru de Artesenato e Culinária (Peabiru Way Handicrafts and Culinary Association) was created, which is marketing specific products and generating opportunities for street vendors to earn more income. It was noticed that through the work already carried out, even though it still in the initial stages, there have been positive effects on the local economy, bringing more income for the population, restaurants, bakers, and gas stations and creating direct and indirect jobs during the weekly events, particularly the walks along the Peabiru Way in the form of Acquatrekking.
A siker szerepe és jelentése a vevő-beszállító kapcsolatban (The meaning and role of success in buyer-supplier relationship)
Authors: Bódi-Schubert Anikó
Published: February 2021

A cikk komplex kvalitatív kutatás eredményeit mutatja be, amelynek célja az volt, hogy feltárja a siker jelentését és szerepét a vevő-beszállító kapcsolatban, s ehhez kapcsolódóan elemezze a siker időbeli viselkedését és az üzleti kapcsolat fejlődésére gyakorolt hatását. A kutatás alapegységét a vevő és beszállító pozícióban levő vállalatok között kialakuló kapcsolatok jelentik, az empirikus vizsgálatok e diadikus kapcsolatok elemzésére összpontosítottak. A kutatás fogalmi kerete megkülönbözteti az üzleti és kapcsolati siker B2B kontextusban értelmezhető tartalmát, ez empirikus vizsgálatok során az utóbbira fókuszálva. A feltáró-fogalomalkotó kutatási célhoz illeszkedően a cikkben ismertetendő kutatási eredmények összehasonlító esettanulmány-feldolgozáson, illetve a megalapozott elmélet segítségével történő szisztematikus tartalomelemzésen nyugszanak. _______ This paper focuses on to introduce the results of an empirical research, which aims to create a conceptual framework on the meaning and role of success in buyer-supplier relationship’s operation and development. Related to this, a further research point is to analyze the time-dimension of success: how success changes and develops over time. The basic elements of this research are the relationships between supplier and buyer business partners, so the empirical study will focus on these dyads. At the theoretical grounding of the paper I highly focused on making a difference between business and relationship success. The introduced research definitely had an exploratory scope. That is why; two qualitative methodologies were applied: the grounded theory and the case study ones.
Kis- és középvállalatok innovációs tevékenysége a válság idején – hálózatok szerepe (Innovation of small and medium-sized enterprises in times of crises – The role of networks)
Authors: Ferincz Adrienn
Published: February 2021

A hálózati megközelítés alapján a vállalatok nem izoláltan működő szervezetek. A kis- és középvállalkozások számára a hálózatok, a partnerkapcsolatok jelentős támogatást képesek biztosítani a növekedés, a tanulás és az innovációs tevékenység során. A szerző a hálózati, partneri kapcsolatok szerepét a válság idején vizsgálta, kvalitatív kutatás keretében. A tanulmány fontos megállapítása, hogy nem kizárólag a hálózatban rejlő lehetőségek, hanem a korábban biztos partneri kapcsolatok megszűnése is indukálhat innovációt a válság idején, valamint a biztonság, a tartalék-erőforrások megléte esetén lassabb a piaci reagálás, kevésbé kerül előtérbe a változás, s főként az innovációs tevékenység ______ Based on the network perspective companies are not isolated organizations. Networks and partnerships mean a significant support for SMEs in growth, learning and innovation. The author examines the role of networks and partnerships during the crisis, in a qualitative research. An important result of the paper is that not only the opportunities in networks but also the decomposition of prior secure relationships can induce innovation during the crisis. Moreover in case of safety and slack resources the reaction is slower, change and innovation come to the front less.
La metáfora biológica en la obra de Manuel González Prada
Authors: Fernández-Cozman Camilo Rubén
Published: February 2021

Manuel González Prada is one of the most important Latin American authors. He used the biological metaphor to criticize Peruvian society in the late nineteenth century. The metaphor of disease, animal and plant are three kinds of analog procedures that González Prada uses according to a naturalistic vision, heiress of Spencer's evolutionism. González Prada questions the imitation and lack of stylistic precision of writers in the nineteenth century, as well as conceiving that Peru is a sick organism
Telemanipulation of an Articulated Robotic Arm using a Commercial Virtual Reality Controller
Authors: Schäfer Max B. , Stewart Kent W. , Lösch Nico , Pott Peter P.
Published: February 2021

Access to systems for robot-assisted surgery is limited due to high costs. To enable widespread use, numerous issues have to be addressed to improve and/or simplify their components. Current systems commonly use universal linkage-based input devices, and only a few applicationoriented and specialized designs are used. A versatile virtual reality controller is proposed as an alternative input device for the control of a seven degree of freedom articulated robotic arm. The real-time capabilities of the setup, replicating a system for robot-assisted teleoperated surgery, are investigated to assess suitability. Image-based assessment showed a considerable system latency of 81.7 ± 27.7 ms. However, due to its versatility, the virtual reality controller is a promising alternative to current input devices for research around medical telemanipulation systems.
Building Characters and Socio-Culture Values to Generation Z of Batik Craftsman Family in Pekalongan
Authors: Mayangsari Cintya Anindita , Utomo Cahyo Budi , Pujiati Amin
Published: February 2021

The use of internet technology allows parents and children activities to be higher and more diverse. From the family aspect, this condition allows changes in the parents’ roles in educating their children. Furthermore, when it is viewed from the children aspect, it is possible to change the meaning of social values ​​by the generation Z. Based on this phenomenon, there are two important issues that need to be studied. First, this research aims to reveal the parents’ roles in building characters of socio-cultural values ​​to Generation Z. Second, it aims to reveal the meaning of socio-cultural values ​​by Generation Z. The research used a qualitative approach with the Habitus theory initiated by Bourdieu as the data analysis technique. The research findings showed that the parents’ roles in building socio-cultural character can be divided into two categories. The first category is families that always provide parental accompaniment to their children and the second category is families that barely provide parental accompaniment to their children. Furthermore, based on the meaning of socio-cultural values, the social interaction value was interpreted as a communication with other people that does not have social implications. The other interpreted social interaction as a communication between two or more people with social implications. The value of solidarity was interpreted as a form of concern for others, while lifestyle was interpreted as a form of appearance that has no social implications and others considered it to have social implications. The value of tolerance was interpreted as the behavior of respecting differences.
The Integration of Living Environmental Education in the Behavior of High School Students in Brebes Regency
Authors: Leksono Karyono Budi , Setyowati Dewi Liesnoor , Hardati Puji
Published: February 2021

Life environment education gains the main priority for formal education. For school stakeholders, this condition should be responded to immediately. Schools have to struggle to improve their learners’ environmental awareness. This research describes and analyzes the Living Environmental education policy, its integration to a geographic lesson, and learners’ environmental awareness behaviors of Senior High Schools in Brebes. This research is qualitative. The data were collected by interviewing, observing, and studying the document. The applied data analysis stages were data reduction, display, and conclusion. The findings showed that 1) the Living Environmental education policy was determined by the school since there were no obligated rules from the government. 2) Living Environmental education integration had been promoted well in a geography lesson. It was realized into learning instrument administration and the learning process. This life environment education could be integrated into almost all basic competencies of all geographic materials. 3) learners were aware of a better living environment. They were aware and could understand the problems and negative impacts. In addition to these, learners also acted and were committed to keeping their life environment.
The Effectiveness of Writing Editorial Texts Learning with the Plural Partner Model A-21 Based on Vocation
Authors: Wulandari Sri , Zulaeha Ida , Wagiran Wagiran
Published: February 2021

Editorial text writing skills involve the students’ abilities to collect references based on experience. Collaboration, communication, and critical and creative thinking activities are indispensable for learning in the 21st century. Plural Partner Model A-21 is used in learning activities to write editorial texts. This study aims to determine the effectiveness of learning to write editorial texts using the Plural Partner A-21 model based on the specialization of vocational students. The research design used was quasi-experimental with a population of XII grade students of SMK in the 2019/2020 academic year. Data collection techniques using test and non-test techniques. The test technique was carried out by measuring the skills of students in writing editorial texts, while the non-test technique was carried out by using questionnaire sheets, observation, and documentation. The data were analyzed using the T-test and analysis of variance (Anova). The results prove that the use of the Plural Partner A-21 model is effective in learning editorial text writing skills based on the specialization of vocational students. Research benefits provide theoretical and practical advantages. Theoretically, this study can enrich the theory of learning to write editorial texts using a combination of the Plural Partner model with 21st century learning skills. The importance of this research for educators to increase the sense of responsibility for the quality of education in an era of disruption.
Phonology of Malay Language in Karimun Regency, Riau Islands
Authors: Kustiah Hariani , Zulaeha Ida , Mardikantoro Hari Bakti
Published: February 2021

The Malay language that is spoken in Karimun Regency is a unique and diverse language. The uniqueness and diversity of the Malay language lies in phonology. The purpose of this study is to analyze the phonological variations and phonological differences of the Malay language in Karimun Regency, Riau Islands. The focused places of this study are located in three districts, namely Karimun District, West-Kundur District and Moro District. This study uses a dialect geography approach and qualitative descriptive. The data were collected by using the listening that is followed by simak libat cakap method, recording, and taking notes technique. The results showed that the Karimun Malay language has phonological variations in the form of vowel and consonant variations. Phonological variations happen due to geographic locations between different observation areas and they are obliviously limited to other regions. The phonological differences of the Karimun Malay language in the three observation places are categorized in speech difference. The results of data calculated is analyzed the phonological dialectometric method of Karimun Malay language in the three observation places is 4-7% in percentage.