The Combined Effects of Long Term Mixture Exposure to Temperature and Relative Humidity on Asthma in China
Authors:   Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China, Huang, MPH Zhongguo , Liu,PhD Tao ,   Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China, Shi Yan ,   Shanghai Municipal Centre for Disease Control and Prevention, Shanghai, 200336, China, Guo Yanfei ,   Shanghai Municipal Centre for Disease Control and Prevention, Shanghai, 200336, China, He PhD Guanhao ,   China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou, 510632, China, Hu, PhD JianXiong ,   China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou, 510632, China, Dong, PhD Xiaomei ,   China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou, 510632, China, Xiao, PhD Jianpeng ,   Shanghai Medical College, Fudan University, Shanghai, 200032, China, Lin, PhD Ziqiang ,   Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China, Wu, PhD Fan ,   Shanghai Medical College, Fudan University, 130 Dong-An Road, Xuhui District, Shanghai, Ma, PhD. Wenjun ,   Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China
Published: May 2024

Background: Few previous stud ies ha ve examined the joint effect of long term exposure to temperature and relative humidity ( RH on ast hma This study endeavors t o explore the combined association between long term co exposure to temperature and R H and asthma in China. Methods: The individual data of asthma were collected from the wave 1 to wave 3 (2007 2019) of the Study on global AGEing and adult health in China. M eteorological factors data were obtained from the European Center for Medium range Weather Forecasts Reanalysis 5 (ERA5) and extracted from the corresponding interpolated grid according to individual residential latitude, longi tude and survey time. Individual and joint association of long term exposure to annual mean temperature and RH with asthma were estimated using Cox regression model and Quantile Based g Computation model Q gcomp)gcomp), respectively Then , the joint effects of different temperature RH compound events w ere further estimated Results: We observed negative association between both temperature and RH with asthma. In individual effect analysis, for 1 °C or 1% decrease in 3 year average temperature and RH , asthma increased 4 44 (95% 1 76 7 0 5) and 6 45 (95% 2 79 9 98 respectively. The joint effect of long term exposure to temperature and RH on asthma was also negative . F or each percentile decreasing of both temperature and RH asthma decreased 1.50% (95%CI: 0.85% 2.15%) in total population . People 60 years old and female were more susceptible to mixture exposure to low temperature and low RH. W e also observed a higher risk of asthma in dry cold event ( 2.44 , 95%CI: 1 67 3 55 than wet cold, wet hot and dry hot events Conclusion: Long term exposure to t emperature and RH may jointly associate with asthma , and low RH and cold may have higher risk on asthma onset .