Development of New Chemiluminescence Systems for Analysis
Authors: Gao Wenyue , Saqib Muhammad , Hanif Saima , Lan Yixiang , Halawa Mohamed Ibrahim , Wang Chao , Fereja Tadesse Haile , Zhang Yanqun , Xu Jingwei , Xu Guobao 
Published: May 2020

Chemiluminescence (CL) is a light-emitting phenomenon as a result of chemical reactions. Luminol and lucigenin are typical CL luminophores, and hydrogen peroxide is typical coreactant. It is an important analytical technique because of its inherent features, such as high sensitivity, wide dynamic range, fast detection, simple equipment, and low instrumentation costs because no external light source or optics is needed. It has been extensively used for immunoassays, DNA detection, enzymatic biosensors, forensic bloodstain detection, pharmaceutical analysis, metal ion determination, imaging and so on. To improve performance of CL analysis and broaden the applications of CL, it is of great importance to develop new CL systems.

Herein, we present some new CL systems such as artemisinin/luminol, thiourea dioxide/luminol, N-hydroxyphthalimide/luminol, hydroxylamine-O-sulfonic acid/luminol, allantoin/ lucigenin and creatinine/H2O2 systems. We will also demonstrate their applications in forensic bloodstain detection, enzyme detection, metal ions detection, and so on [1-7].

Acknowledgment

We are grateful for financial support from the National Key Research and Development Program of China (No. 2016YFA0201300), National Natural Science Foundation of China (Nos. 21874126,21675148), the Chinese Academy of Sciences (CAS)-the Academy of Sciences for the Developing World (TWAS), President’s Fellowship Program, and the CAS President's International Fellowship Initiative (PIFI) project.

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