bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Phosphabenzenes by an Iron‐Catalyzed [2+2+2] Cycloaddition Reaction of Diynes with Phosphaalkynes
Authors: Nakajima Kazunari , Takata Shohei , Sakata Ken , Nishibayashi Yoshiaki
Published: May 2015

A method for the synthesis of phosphabenzenes under iron catalysis is described. Thus, the FeI2‐catalyzed [2+2+2] cycloaddition of diynes with phosphaalkynes in m‐xylene gave a variety of phosphabenzenes in good to high yields (up to 87 % yield).
Cooperative Crystallization of Heterometallic Indium–Chromium Metal–Organic Polyhedra and Their Fast Proton Conductivity
Authors: Zhai Quan‐Guo , Mao Chengyu , Zhao Xiang , Lin Qipu , Bu Fei , Chen Xitong , Bu Xianhui , Feng Pingyun
Published: May 2015

Metal–organic polyhedra (MOPs) or frameworks (MOFs) based on Cr3+ are notoriously difficult to synthesize, especially as crystals large enough to be suitable for characterization of the structure or properties. It is now shown that the co‐existence of In3+ and Cr3+ induces a rapid crystal growth of large single crystals of heterometallic In‐Cr‐MOPs with the [M8L12] (M=In/Cr, L=dinegative 4,5‐imidazole‐dicarboxylate) cubane‐like structure. With a high concentration of protons from 12 carboxyl groups decorating every edge of the cube and an extensive H‐bonded network between cubes and surrounding H2O molecules, the newly synthesized In‐Cr‐MOPs exhibit an exceptionally high proton conductivity (up to 5.8×10−2 S cm−1 at 22.5 °C and 98 % relative humidity, single crystal).
Mechanistic Insight into the Stereochemical Control of Lactide Polymerization by Salan–Aluminum Catalysts
Authors: Press Konstantin , Goldberg Israel , Kol Moshe
Published: May 2015

Alkyl aluminum complexes of chiral salan ligands assembled around the 2,2′‐bipyrrolidine core form as single diastereomers that have identical configurations of the N donors. Active catalysts for the polymerization of lactide were formed upon the addition of benzyl alcohol. Polymeryl exchange between enantiomorphous aluminum species had a dramatic effect on the tacticity of the poly(lactic acid) (PLA) in the polymerization of racemic lactide (rac‐LA): The enantiomerically pure catalyst of the nonsubstituted salan ligand led to isotactic PLA, and the racemic catalyst exhibited lower stereocontrol. The enantiomerically pure catalyst of the chloro‐substituted salan ligand led to PLA with a slight tendency toward heterotacticity, whereas the racemic catalyst led to PLA of almost perfect heterotacticity following an insertion/auto‐inhibition/exchange mechanism.
Rhodium(I)‐Catalyzed Sequential C(sp)C(sp3) and C(sp3)C(sp3) Bond Formation through Migratory Carbene Insertion
Authors: Xia Ying , Feng Sheng , Liu Zhen , Zhang Yan , Wang Jianbo
Published: May 2015

A RhI‐catalyzed three‐component reaction of tert‐propargyl alcohol, diazoester, and alkyl halide has been developed. This reaction can be considered as a carbene‐involving sequential alkyl and alkynyl coupling, in which C(sp)C(sp3) and C(sp3)C(sp3) bonds are built successively on the carbenic carbon atom. The RhI‐carbene migratory insertion of an alkynyl moiety and subsequent alkylation are proposed to account for the two separate CC bond formations. This reaction provides an efficient and tunable method for the construction of all‐carbon quaternary center.
Multicolor Fluorescence Writing Based on Host–Guest Interactions and Force‐Induced Fluorescence‐Color Memory
Authors: Matsunaga Yuki , Yang Jye‐Shane
Published: May 2015

A new strategy is reported for multicolor fluorescence writing on thin solid films with mechanical forces. This concept is illustrated by the use of a green‐fluorescent pentiptycene derivative 1, which forms variably colored fluorescent exciplexes: a change from yellow to red was observed with anilines, and fluorescence quenching (a change to black) occurred in the presence of benzoquinone. Mechanical forces, such as grinding and shearing, induced a crystalline‐to‐amorphous phase transition in both the pristine and guest‐adsorbed solids that led to a change in the fluorescence color (mechanofluorochromism) and a memory of the resulting color. Fluorescence drawings of five or more colors were created on glass or paper and could be readily erased by exposure to air and dichloromethane fumes. The structural and mechanistic aspects of the observations are also discussed.
One‐Step Formation of “Chain‐Armor”‐Stabilized DNA Nanostructures
Authors: Cassinelli Valentina , Oberleitner Birgit , Sobotta Jessica , Nickels Philipp , Grossi Guido , Kempter Susanne , Frischmuth Thomas , Liedl Tim , Manetto Antonio
Published: May 2015

DNA‐based self‐assembled nanostructures are widely used to position organic and inorganic objects with nanoscale precision. A particular promising application of DNA structures is their usage as programmable carrier systems for targeted drug delivery. To provide DNA‐based templates that are robust against degradation at elevated temperatures, low ion concentrations, adverse pH conditions, and DNases, we built 6‐helix DNA tile tubes consisting of 24 oligonucleotides carrying alkyne groups on their 3′‐ends and azides on their 5′‐ends. By a mild click reaction, the two ends of selected oligonucleotides were covalently connected to form rings and interlocked DNA single strands, so‐called DNA catenanes. Strikingly, the structures stayed topologically intact in pure water and even after precipitation from EtOH. The structures even withstood a temperature of 95 °C when all of the 24 strands were chemically interlocked.
A PEGylated Photocleavable Auxiliary Mediates the Sequential Enzymatic Glycosylation and Native Chemical Ligation of Peptides
Authors: Bello Claudia , Wang Shuo , Meng Lu , Moremen Kelley W. , Becker Christian F. W.
Published: May 2015

Research aimed at understanding the specific role of glycosylation patterns in protein function would greatly benefit from additional approaches allowing direct access to homogeneous glycoproteins. Herein the development and application of an efficient approach for the synthesis of complex homogenously glycosylated peptides based on a multifunctional photocleavable auxiliary is described. The presence of a PEG polymer within the auxiliary enables sequential enzymatic glycosylation and straightforward isolation in excellent yields. The auxiliary‐modified peptides can be directly used in native chemical ligations with peptide thioesters easily obtained by direct hydrazinolysis of the respective glycosylated peptidyl resins and subsequent oxidation. The ligated glycopeptides can be smoothly deprotected by UV irradiation. We apply this approach to the preparation of variants of the epithelial tumor marker MUC1 carrying one or more Tn, T, or sialyl‐T antigens.
Design of hemocompatible poly(DMAEMA‐co‐PEGMA) hydrogels for controlled release of insulin
Authors: Tayo Lemmuel L. , Venault Antoine , Constantino Vryan Gil R. , Caparanga Alvin R. , Chinnathambi Arunachalam , Ali Alharbi Sulaiman , Zheng Jie , Chang Yung
Published: May 2015

This works aims at (i) studying the antiadhesive properties and the hemocompatibility of poly[2‐(dimethylamino)ethyl methacrylate]‐co‐poly[(ethylene glycol)methacrylate] [poly(DMAEMA‐co‐PEGMA)] copolymers and (ii) investigating the insulin delivery kinetics through hydrogels at physiological pH. A series of poly(DMAEMA‐co‐PEGMA) hydrogels have been synthesized, and their controlled composition was confirmed by X‐ray photoelectron spectroscopy. Then, antibiofouling properties of hydrogels—fibrinogen, erythrocytes, and thrombocytes adhesion—are correlated to their molecular compositions through their hydrophilic properties. As DMAEMA/PEGMA ratio of 70/30 (D70) offers the best compromise between pH sensitivity and hemocompatibility, it is selected for investigating the kinetic rate of insulin release at physiological pH, and the diffusion coefficient of insulin in gel is found to be 0.64 × 10−7 cm2 s−1. Overall, this study unveils that poly(DMAEMA‐co‐PEGMA) copolymers are promising hemocompatible materials for drug delivery systems. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42365.
Coagulation factor IX regulates cell migration and adhesion in vitro
Authors: Kitano Hisataka , Mamiya Atsushi , Tomomi Ishikawa , Shinichiro Kokubun , Chiaki Hidai
Published: May 2015

Coagulation factor IX is thought to circulate in the blood as an inactive zymogen before being activated in the coagulation process. The effect of coagulation factor IX on cells is poorly understood. This study aimed to evaluate the effects of intact coagulation factor IX and its cleavage fragments on cell behavior. A431 cells (derived from human squamous cell carcinoma), Pro5 cells (derived from mouse embryonic endothelial cells), Cos7 cells, and human umbilical vein endothelial cells were utilized in this study. The effects of coagulation factor IX and its cleavage fragments on cell behavior were investigated in several types of experiments, including wound‐healing assays and modified Boyden chamber assays. The effect of coagulation factor IX depended on its processing; full‐length coagulation factor IX suppressed cell migration, increased adhesion to matrix, and enhanced intercellular adhesion. In contrast, activated coagulation factor IX enhanced cell migration, suppressed adhesion to matrix, and inhibited intercellular adhesion. An activation peptide that is removed during the coagulation process was found to be responsible for the activity of full‐length coagulation factor IX, and the activity of activated coagulation factor IX was localized to an EGF domain of the coagulation factor IX light chain. Full‐length coagulation factor IX has a sedative effect on cells, which is counteracted by activated coagulation factor IX in vitro. Thus, coagulation factor IX may play roles before, during, and after the coagulation process.
Supercubooctahedron (Cs6Cl)2Cs5[Ga15Ge9Se48] Exhibiting Both Cation and Anion Exchange
Authors: Huang‐Fu Shang‐Xiong , Shen Jin‐Ni , Lin Hua , Chen Ling , Wu Li‐Ming
Published: May 2015

A novel type of supertetrahedral connectivity is exhibited by the 72‐atom discrete supercubooctahedron in (Cs6Cl)2Cs5[Ga15Ge9Se48] (1), which undergoes both cation and anion exchange, as revealed by unambiguous single‐crystal X‐ray diffraction data. Electronic‐structure studies helped to understand the Ge/Ga distribution.
Yolk‐Shell Porous Microspheres of Calcium Phosphate Prepared by Using Calcium L‐Lactate and Adenosine 5′‐Triphosphate Disodium Salt: Application in Protein/Drug Delivery
Authors: Ding Guan‐Jun , Zhu Ying‐Jie , Qi Chao , Sun Tuan‐Wei , Wu Jin , Chen Feng
Published: May 2015

A facile and environmentally friendly approach has been developed to prepare yolk‐shell porous microspheres of calcium phosphate by using calcium L‐lactate pentahydrate (CL) as the calcium source and adenosine 5′‐triphosphate disodium salt (ATP) as the phosphate source through the microwave‐assisted hydrothermal method. The effects of the concentration of CL, the microwave hydrothermal temperature, and the time on the morphology and crystal phase of the product are investigated. The possible formation mechanism of yolk‐shell porous microspheres of calcium phosphate is proposed. Hemoglobin from bovine red cells (Hb) and ibuprofen (IBU) are used to explore the application potential of yolk‐shell porous microspheres of calcium phosphate in protein/drug loading and delivery. The experimental results indicate that the as‐prepared yolk‐shell porous microspheres of calcium phosphate have relatively high protein/drug loading capacity, sustained protein/drug release, favorable pH‐responsive release behavior, and a high biocompatibility in the cytotoxicity test. Therefore, the yolk‐shell porous microspheres of calcium phosphate have promising applications in various biomedical fields such as protein/drug delivery.
Aromatic Interactions in Organocatalyst Design: Augmenting Selectivity Reversal in Iminium Ion Activation
Authors: Holland Mareike C. , Metternich Jan Benedikt , Daniliuc Constantin , Schweizer W. Bernd , Gilmour Ryan
Published: May 2015

Substituting N‐methylpyrrole for N‐methyindole in secondary‐amine‐catalysed Friedel–Crafts reactions leads to a curious erosion of enantioselectivity. In extreme cases, this substrate dependence can lead to an inversion in the sense of enantioinduction. Indeed, these closely similar transformations require two structurally distinct catalysts to obtain comparable selectivities. Herein a focussed molecular editing study is disclosed to illuminate the structural features responsible for this disparity, and thus identify lead catalyst structures to further exploit this selectivity reversal. Key to effective catalyst re‐engineering was delineating the non‐covalent interactions that manifest themselves in conformation. Herein we disclose preliminary validation that intermolecular aromatic (CH–π and cation–π) interactions between the incipient iminium cation and the indole ring system is key to rationalising selectivity reversal. This is absent in the N‐methylpyrrole alkylation, thus forming the basis of two competing enantio‐induction pathways. A simple L‐valine catalyst has been developed that significantly augments this interaction.
Alloyed ZnS–CuInS2 Semiconductor Nanorods and Their Nanoscale Heterostructures for Visible‐Light‐Driven Photocatalytic Hydrogen Generation
Authors: Ye Chen , Regulacio Michelle D. , Lim Suo Hon , Li Shuang , Xu Qing‐Hua , Han Ming‐Yong
Published: May 2015

A promising photocatalytic system in the form of heterostructured nanocrystals (HNCs) is presented wherein alloyed ZnS–CuInS2 (ZCIS) semiconductor nanorods are decorated with Pt and Pd4S nanoparticles. This is apparently the first report on the colloidal preparation and photocatalytic behavior of ZCIS–Pt and ZCIS–Pd4S nanoscale heterostructures. Incorporation of Pt and Pd4S cocatalysts leads to considerable enhancement of the photocatalytic activity of ZCIS for visible‐light‐driven hydrogen production.
Can Helical Peptides Unwind One Turn at a Time? ‐ Controlled Conformational Transitions in α,β2,3‐Hybrid Peptides
Authors: Balamurugan Dhayalan , Muraleedharan Kannoth M.
Published: May 2015

Unfolding of helical trans‐β2,3‐hybrid peptides with (α–β)nα composition, when executed by increasing solvent polarity or temperature, proceeded in a systematic manner with the turns unwinding sequentially; C‐terminal region of these peptides were first to unwind and the process propagated towards N terminus with more and more β residues equilibrating from the gauche to the anti rotameric state across CαCβ. This is evidenced by clear change in their CβH signal splitting, 3JCαH–CβH values, and sequential disappearance of i,i+2 NOEs.
ChemInform Abstract: Synthesis and Crystal Structures of Rb4Al2S5 and Cs4In2S5.
Authors: Winkler Verena , Schlosser Marc , Pfitzner Arno
Published: May 2015

The new compounds Rb4Al2S5 (I) and Cs4In2S5 (II) are prepared by the azide route using RbN3 (CsN3), Al (In), and S in the molar ratio of 4:2:5 (evacuated quartz tubes, 500 °C, 8‐10 d) which in case of compound (II) is repeated for 15 d.
ChemInform Abstract: Synthesis and Characterization of Mid‐Infrared Transparency Compounds: Acentric BaHgS2 and Centric Ba8Hg4S5Se7.
Authors: Wu Kui , Su Xin , Pan Shilie , Yang Zhihua
Published: May 2015

Crystalline acentric BaHgS2 (I) and centric Ba8Hg4S5Se7 (II) are prepared by solid state reaction of stoichiometric amounts of BaS (and BaSe) and HgS (evacuated quartz tubes, 850 °C resp.
ChemInform Abstract: A Facile Route to Aqueous Ag:ZnCdS and Ag:ZnCdSeS Quantum Dots: Pure Emission Color Tunable over Entire Visible Spectrum.
Authors: Zeng Ruosheng , Sun Zhiguo , Cao Sheng , Shen Rongan , Liu Zuoji , Long Jintao , Zheng Jinju , Shen Yayun , Lin Xiangnan
Published: May 2015

Aqueous Ag:ZnCdS quantum dots (QDs) are prepared based on a co‐nucleation doping strategy using aqueous solutions of Cd(OAc)2, Zn(OAc)2 (in presence of mercaptopropionic acid; Cd:Zn molar ratio of 1:1), and AgNO3 at pH 7 to which a reactive S (and Se) powder precursor (hydrothermal S (Se) solution in presence of NaBH4) is given (autoclave, 180 °C, 2 h).
ChemInform Abstract: Structural and Magnetic Properties of Nd2NiGe3.
Authors: Sarkar Sumanta , Kalsi Deepti , Rayaprol Sudhindra , Peter Sebastian C.
Published: May 2015

The title compound is prepared by arc melting of stoichiometric amounts of the elements followed by annealing (1173 K, 10 d).
ChemInform Abstract: New Hard Magnetic Phase in Mn—Ga—Al System Alloys.
Authors: Saito Tetsuji , Nishio‐Hamane Daisuke
Published: May 2015

Ingots of Mn65Ga35‐xAlx (x = 0‐25) are prepared by arc melting of the elements followed by melt spinning and annealing of the resulting ribbons (973 K, 1 h).
ChemInform Abstract: (BiSe)1.23CrSe2 and (BiSe)1.22(Cr1.2Se2)2: Magnetic Anisotropy in the First Structurally Characterized Bi—Se—Cr Ternary Compounds.
Authors: Clarke Samantha M. , Freedman Danna E.
Published: May 2015

The misfit layer compounds (BiSe)1.23CrSe2 (I) and (BiSe)1.22(Cr1.2Se2)2 (II) are prepared by solid state reaction of Bi2Se3 and Cr2Se3 (C‐coated evacuated silica tubes, 780 °C, 165 h; controlled cooling).
ChemInform Abstract: Ga4B2O9: An Efficient Borate Photocatalyst for Overall Water Splitting Without Cocatalyst.
Authors: Wang Guangjia , Jing Yan , Ju Jing , Yang Dingfeng , Yang Jia , Gao Wenliang , Cong Rihong , Yang Tao
Published: May 2015

Ga4B2O9 is prepared by hydrothermal (HY), sol‐gel (SG), and high‐temperature solid state (HTSSR) reactions.
ChemInform Abstract: Positional Flexibility: Syntheses and Characterization of Six Uranium Chalcogenides Related to the 2H Hexagonal Perovskite Family.
Authors: Mesbah Adel , Prakash Jai , Beard Jessica C. , Pozzi Eric A. , Tarasenko Mariya S. , Lebegue Sebastien , Malliakas Christos D. , Van Duyne Richard P. , Ibers James A.
Published: May 2015

Ba4USe6 (I), Ba3FeUSe6 (II), Ba3MnUSe6 (III), Ba3MnUS6 (IV), Ba3.3Rb0.7US6 (V), and Ba3.2K0.8US6 (VI) are prepared by solid state reaction of stoichiometric amounts of the elements and CsCl, RbCl, and KCl acting as a flux (C‐coated evacuated silica tubes, 1173 K, 4 d; cooling to 673 K at a rate of 2.5 K/h).
ChemInform Abstract: The [U2(μ‐S2)2Cl8]4‐ Anion: Synthesis and Characterization of the Uranium Double Salt Cs5 [U2(μ‐S2)2Cl8]I.
Authors: Ward Matthew D. , Pozzi Eric A. , Lee Minseong , Van Duyne Richard P. , Choi Eun Sang , Ibers James A.
Published: May 2015

Single crystals of Cs5[U2(μ‐S2)2Cl8]I are obtained by solid state reaction of U, GeI2 or SnI4, S, and CsCl as flux in a 1:1:3:3.5 molar ratio (C‐coated evacuated silica tubes, complex heating and cooling schedule, 75 wt% yield).
ChemInform Abstract: Chemoselective Reductive Nucleophilic Addition to Tertiary Amides, Secondary Amides, and N‐Methoxyamides.
Authors: Nakajima Minami , Oda Yukiko , Wada Takamasa , Minamikawa Ryo , Shirokane Kenji , Sato Takaaki , Chida Noritaka
Published: May 2015

The title transformation consists of (i) reduction of the amide carbonyl group, (ii) formation of an iminium ion with an acid, and (iii) C—C bond formation with a mild nucleophile.
ChemInform Abstract: New 1,4‐Anthracenedione Derivatives with Fused Heterocyclic Rings: Synthesis and Biological Evaluation.
Authors: Castro Ma. Angeles , Gamito Ana Ma. , Tangarife‐Castano Veronica , Roa‐Linares Vicky , Miguel del Corral Jose Ma. , Mesa‐Arango Ana C. , Betancur‐Galvis Liliana , Francesch Andres M. , San Feliciano Arturo
Published: May 2015

Various terpenylquinones are synthesized by nucleophilic addition or substitution reactions of 1,4‐anthracenediones and further transformed into extended polycyclic systems, which mainly keep the 1,4‐quinone moiety fused to different nitrogen‐ heterocyclic rings into the structure.
ChemInform Abstract: Iridium‐Catalyzed Reductive Nitro‐Mannich Cyclization.
Authors: Gregory Alex W. , Chambers Alan , Hawkins Alison , Jakubec Pavol , Dixon Darren J.
Published: May 2015

The synthetic utility of this highly diastereoselective cyclization is demonstrated in the synthesis of racemic epi‐epiquinamide (VIII).
ChemInform Abstract: Air‐Stable Cationic Gold(I) Catalyst Featuring a Z‐Type Ligand: Promoting Enyne Cyclizations.
Authors: Inagaki Fuyuhiko , Matsumoto Chiaki , Okada Yasuhiko , Maruyama Naoya , Mukai Chisato
Published: May 2015

An air‐stable cationic AuI complex featuring a Z‐type ligand (boron atom) as a σ‐acceptor is developed for elucidating the effect of B on catalytic reactions.
ChemInform Abstract: Intramolecular Annulation of Aromatic Rings with N‐Sulfonyl 1,2,3‐Triazoles: Divergent Synthesis of 3‐Methylene‐2,3‐dihydrobenzofurans and 3‐Methylene‐2,3‐dihydroindoles.
Authors: Tang Xiang‐Ying , Zhang Yong‐Sheng , He Lv , Wei Yin , Shi Min
Published: May 2015

The controllable and chemoselective synthesis of the title benzofurans and indoles is established through annulation of aromatic rings with N‐sulfonyl 1,2,3‐triazoles.
ChemInform Abstract: Lewis Acid‐Catalyzed Generation of C—C and C—N Bonds on π‐Deficient Heterocyclic Substrates.
Authors: Staderini Matteo , Bolognesi Maria Laura , Menendez J. Carlos
Published: May 2015

By the microwave irradiation of chlorinated N‐heterocycles in presence of nucleophiles aromatic C—C or C—N bonds are generated regioselectively.
ChemInform Abstract: Silver‐Catalyzed Radical Fluorination of Alkylboronates in Aqueous Solution.
Authors: Li Zhaodong , Wang Zhentao , Zhu Lin , Tan Xinqiang , Li Chaozhong
Published: May 2015

The transformation of primary and secondary boronic acids as well as primary, secondary and tertiary pinacolates and bispinacolates to the corresponding fluorides is described.
ChemInform Abstract: IrIII‐Catalyzed Direct C‐7 Amidation of Indolines with Sulfonyl, Acyl, and Aryl Azides at Room Temperature.
Authors: Hou Wei , Yang Yaxi , Ai Wen , Wu Yunxiang , Wang Xuan , Zhou Bing , Li Yuanchao
Published: May 2015

A general procedure for an IrIII‐catalyzed C‐7 selective C—H amidation and amination of indolines is reported.
ChemInform Abstract: Hybrid Au/Pd Nanoparticles as Reusable Catalysts for Heck Coupling Reactions in Water under Aerobic Conditions.
Authors: Nasrollahzadeh Mahmoud , Banaei Alireza
Published: May 2015

Ligand‐free Heck coupling reactions of styrenes and alkyl acrylates with aryl bromides and iodides provide the corresponding products in high yields.
ChemInform Abstract: A Nickel‐Mediated Oxidative α‐C(sp3)—H Functionalization of Amides with Allylic Alcohols Terminated by Radical 1,2‐Aryl Migration.
Authors: Song Ren‐Jie , Tu Yong‐Qiang , Zhu Dao‐Yong , Zhang Fu‐Min , Wang Shao‐Hua
Published: May 2015

The reaction of symmetric α,α‐diaryl allylic alcohols (I) with ureas and amides is accompanied by a 1,2‐aryl migration leading to ketones (III) and (VIII).
ChemInform Abstract: Copper‐Catalyzed Cascade Reactions of α,β‐Unsaturated Esters with Keto Esters.
Authors: Li Zhengning , Wang Chongnian , Li Zengchang
Published: May 2015

The reaction proceeds through conjugate addition of copper hydride, generated in situ, to α,β‐unsaturated esters, followed by the aldolization with a keto ester and lactonization.
ChemInform Abstract: A Sulfonate‐Based Cu(I) Metal‐Organic Framework as a Highly Efficient and Reusable Catalyst for the Synthesis of Propargylamines under Solvent‐Free Conditions.
Authors: Li Peng , Regati Sridhar , Huang Hui‐Cai , Arman Hadi D. , Chen Bang‐Lin , Zhao John C.‐G.
Published: May 2015

via three‐component reaction of cyclic amines, aromatic aldehydes and alkynes
ChemInform Abstract: 2‐Aminobenzimidazole Organocatalyzed Asymmetric Amination of Cyclic 1,3‐Dicarbonyl Compounds.
Authors: Trillo Paz , Gomez‐Martinez Melania , Alonso Diego A. , Baeza Alejandro
Published: May 2015

In contrast to cyclic 1,3‐dicarbonyl compounds, which are aminated in high yields and with low to good enantioselectivities, acyclic derivatives afford racemic mixtures.
ChemInform Abstract: Rhodium(III)‐Catalyzed C—H Allylation of Electron‐Deficient Alkenes with Allyl Acetates.
Authors: Feng Chao , Feng Daming , Loh Teck‐Peng
Published: May 2015

A novel rhodium‐catalyzed intermolecular direct C—H olefinic allylation of electron‐deficient alkenes with easily available allyl acetates as electrophiles is developed.
ChemInform Abstract: Ligand‐ and Base‐Free CuII‐Mediated Selective S‐Arylation of α‐Enolic Dithioesters by Chan‐Lam Coupling at Room Temperature.
Authors: Koley Suvajit , Chowdhury Sushobhan , Chanda Tanmoy , Ramulu B. Janaki , Anand Namrata , Singh Maya Shankar
Published: May 2015

The ligand‐ and base‐free copper(II)‐mediated Chan—Lam cross‐coupling of arylboronic acids with α‐enolic dithioesters is achieved at room temperature under aerobic neutral conditions to afford unsymmetrical α‐oxoketene S,S‐acetals for the first time.
ChemInform Abstract: Visible Light Induced Cyclopropanation of Dibromomalonates with Alkenes via Double‐SET by Photoredox Catalysis.
Authors: Zhang Yanbin , Qian Rong , Zheng Xingliang , Zeng Yi , Sun Jing , Chen Yiyong , Ding Aishun , Guo Hao
Published: May 2015

The green synthesis of cyclopropanes (III) is carried out under visible light or sunlight with similar high yields.
ChemInform Abstract: Asymmetric Synthesis of Fully Substituted Cyclopentane‐Oxindoles Through an Organocatalytic Triple Michael Domino Reaction.
Authors: Zou Liang‐Hua , Philipps Arne R. , Raabe Gerhard , Enders Dieter
Published: May 2015

An efficient, highly stereoselective asymmetric synthesis of fully functionalized cyclopentanes bearing an oxindole moiety and several other functional groups in one pot is developed.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Benzoin Strategy for Divergent Synthesis of Cyclitol Derivatives from Alditols.
Authors: Kang Bubwoong , Sutou Toshiaki , Wang Yinli , Kuwano Satoru , Yamaoka Yousuke , Takasu Kiyosei , Yamada Ken‐ichi
Published: May 2015

The synthesis of cyclitol derivatives from C2‐symmetrical dialdoses is reported.
ChemInform Abstract: Remote meta‐C—H Olefination of Phenylacetic Acids Directed by a Versatile U‐Shaped Template.
Authors: Deng Youqian , Yu Jin‐Quan
Published: May 2015

Meta‐C—H olefination of phenylacetic acid derivatives has been achieved using a commercially available nitrile‐containing template.
ChemInform Abstract: Highly Enantioselective Hydrogenation of N‐Aryl Imines Derived from Acetophenones by Using Ru‐Pybox Complexes under Hydrogenation or Transfer Hydrogenation Conditions in Isopropanol.
Authors: Menendez‐Pedregal Estefania , Vaquero Monica , Lastra Elena , Gamasa Pilar , Pizzano Antonio
Published: May 2015

The asymmetric reduction of N‐aryl imines derived from acetophenones by using Ru complexes bearing both a pybox and a monodentate phosphite ligand is described.
ChemInform Abstract: Ceric Ammonium Nitrate (CAN) Promoted PdII‐Catalyzed Substrate‐Directed o‐Benzoxylation and Decarboxylative o‐Aroylation.
Authors: Santra Sourav Kumar , Banerjee Arghya , Khatun Nilufa , Patel Bhisma K.
Published: May 2015

Inexpensive ceric ammonium nitrate (CAN) is an efficient oxidant for Pd‐catalyzed substrate‐directed o‐benzoxylation and decarboxylative o‐aroylation processes.
ChemInform Abstract: A Lewis Acid Activated Reaction of Zn with EtI to Promote Highly Enantioselective Alkyne Additions to Aldehydes.
Authors: Chen Shan‐yong , Liu Winnie , Wu Xuedan , Ying Jun , Yu Xiaoqi , Pu Lin
Published: May 2015

The reaction of Zn with EtI is activated at room temperature by using BINOL and Ti(OiPr)4 which can then promote the highly enantioselective alkyne addition to aromatic aldehydes.
ChemInform Abstract: Metal‐Free Protocol for the Synthesis of α‐Bromo Ketones from Olefins Using TsNBr2.
Authors: Rajbongshi Kamal Krishna , Hazarika Debojit , Phukan Prodeep
Published: May 2015

This simple protocol allows the efficient conversion of aromatic and aliphatic olefins into α‐bromo ketones in short reaction times.
ChemInform Abstract: Copper‐Catalyzed Amide Bond Formation from Formamides and Carboxylic Acids.
Authors: Liu Hong‐Qiang , Liu Jun , Zhang Yang‐Hui , Shao Chang‐Dong , Yu Jing‐Xun
Published: May 2015

39 examples in all
ChemInform Abstract: Synthesis of Secondary Amides from N‐Substituted Amidines by Tandem Oxidative Rearrangement and Isocyanate Elimination.
Authors: Debnath Pradip , Baeten Mattijs , Lefevre Nicolas , Van Daele Stijn , Maes Bert U. W.
Published: May 2015

This new, efficient tandem process for the transformation of N‐substituted amidines into secondary amides is applicable for aliphatic and (hetero)aromatic compounds.
ChemInform Abstract: Direct Conversion of Aromatic Aldehydes into Benzamides via Oxidation with Potassium Permanganate in Liquid Ammonia.
Authors: Antoniak Damian , Sakowicz Arkadiusz , Loska Rafal , Makosza Mieczyslaw
Published: May 2015

The scope of the title reaction may be limited by the formation of the corresponding carboxylic acid as a side product.
ChemInform Abstract: Fast and Highly Chemoselective Alkynylation of Thiols with Hypervalent Iodine Reagents Enabled Through a Low Energy Barrier Concerted Mechanism.
Authors: Frei Reto , Wodrich Matthew D. , Hari Durga Prasad , Borin Pierre‐Antoine , Chauvier Clement , Waser Jerome
Published: May 2015

The reaction tolerates alkyl and aryl ethynyl substituted benziodoxolone reagents equipped with various functional groups.
ChemInform Abstract: Organocatalytic Enantioselective Sulfur‐Michael Addition of Thioacetic Acid to Arylmethylidenemalonates.
Authors: Wang Renchao , Liu Jing , Xu Jiaxi
Published: May 2015

The novel protocol for the metal‐free catalysis of the sulfur‐Michael addition furnishes acetylthiomethylmalonate in high yields and high enantiomeric excess.
ChemInform Abstract: Pd(II)‐Catalyzed C—H Arylation of Aryl and Benzyl Weinreb Amides.
Authors: Wang Yan , Zhou Kai , Lan Quan , Wang Xi‐Sheng
Published: May 2015

Whereas 3‐ and 4‐substituted aryl Weinreb amides react with 3‐ and 4‐substituted aryl iodides to afford monoarylated products and only trace amounts of diarylated compounds, 2‐substituted aryl Weinreb amides as well as 2‐substituted aryl iodides are unreactive.
ChemInform Abstract: Synthesis, Characterization and the Suzuki—Miyaura Coupling Reactions of N‐Heterocyclic Carbene—Pd(II)—Pyridine (PEPPSI) Complexes.
Authors: Yasar Sedat , Sahin Caglar , Arslan Murat , Oezdemir Ismail
Published: May 2015

A series of new air and moisture‐stable PEPPSI complexes are developed and evaluated for their catalytic performance in Suzuki cross‐coupling reactions.
ChemInform Abstract: Palladium‐Catalyzed α‐Arylation of Arylketones at Low Catalyst Loadings.
Authors: Marelli Enrico , Corpet Martin , Davies Sian R. , Nolan Steven P.
Published: May 2015

A general protocol for the α‐arylation of ketones with aryl chlorides is developed.
ChemInform Abstract: Erbium Trifluoromethanesulfonate Catalyzed Friedel—Crafts Acylation Using Aromatic Carboxylic Acids as Acylating Agents under Monomode‐Microwave Irradiation.
Authors: Tran Phuong Hoang , Hansen Poul Erik , Nguyen Hai Truong , Le Thach Ngoc
Published: May 2015

The reaction is conducted under environmentally benign conditions.
ChemInform Abstract: Synthesis of 4‐Sulfonatobenzylphosphines and Their Application in Aqueous‐Phase Palladium‐Catalyzed Cross‐Coupling.
Authors: Moore Jane N. , Laskay Nicholas M. , Duque Kevin S. , Kelley Steven P. , Rogers Robin D. , Shaughnessy Kevin H.
Published: May 2015

Two new air‐stable, zwitterionic phosphonium salts are synthesized and applied as ligands in Pd‐catalyzed cross coupling reactions in aqueous phases.
ChemInform Abstract: Synthesis of 2‐Acyl‐1‐naphthols by Gold‐Catalyzed Oxidative Cyclization of 2‐Alkenylphenyl Alkynyl Ketones.
Authors: Matsuda Takanori , Nishida Yahiro , Yamanaka Kentaro , Sakurai Yusuke
Published: May 2015

2‐Acyl‐1‐naphthols [(II) and (IV)] as well as benzothiophenol (VI) and 10‐acyl‐9‐phenanthrenol (VIII), e.
ChemInform Abstract: Central—Axial—Central Chirality Transfer: Asymmetric Synthesis of Highly Substituted Indenes Bearing a Stereogenic Quaternary Carbon Center from Optically Active Propargyl Alcohols.
Authors: Egi Masahiro , Shimizu Kaori , Kamiya Marin , Ota Yuya , Akai Shuji
Published: May 2015

A new, convenient, and environmentally benign route to synthesize a variety of highly substituted indene derivatives bearing a quaternary stereogenic carbon center is reported.
ChemInform Abstract: Synthesis of Novel Symmetrical 2‐Oxo‐spiro[indole‐3,4′‐pyridines] by a Reaction of Oxindoles with 1,2‐Diaza‐1,3‐dienes.
Authors: Attanasi Orazio A. , Campisi Linda A. , De Crescentini Lucia , Favi Gianfranco , Mantellini Fabio
Published: May 2015

The practical two‐step reaction sequence is based on a Michael addition/cyclization approach.
ChemInform Abstract: Rhodium(III)‐Catalyzed Three‐Component Reaction of Imines, Alkynes, and Aldehydes through C—H Activation.
Authors: Huang Ji‐Rong , Song Qiang , Zhu Yu‐Qin , Qin Liu , Qian Zhi‐Yong , Dong Lin
Published: May 2015

The operationally simple and atom‐economical reaction allows for the regio‐ and diastereoselective formation of four bonds, thus offering a powerful strategy toward polycyclic skeletons with potential biological activity.
ChemInform Abstract: Iron‐Catalyzed Acylation‐Oxygenation of Terminal Alkenes for the Synthesis of Dihydrofurans Bearing a Quaternary Carbon.
Authors: Lv Leiyang , Lu Shenglin , Guo Qiaoxia , Shen Baojian , Li Zhiping
Published: May 2015

A new and practical strategy for the acylation‐oxygenation of terminal alkenes in the presence of an iron catalyst is described.
ChemInform Abstract: Electrochemical Selenium‐ and Iodonium‐Initiated Cyclization of Hydroxy‐Functionalized 1,4‐Dienes.
Authors: Roese Philipp , Emge Steffen , Yoshida Jun‐ichi , Hilt Gerhard
Published: May 2015

The electrochemical selenium‐initiated cyclization goes along with oxidation of the corresponding alcohol in less than 10%.
ChemInform Abstract: Synthesis of Highly Substituted γ‐Butyrolactones by a Gold‐Catalyzed Cascade Reaction of Benzyl Esters.
Authors: Blanco Jaimes Maria Camila , Ahrens Alexander , Pflaesterer Daniel , Rudolph Matthias , Hashmi A. Stephen K.
Published: May 2015

γ‐butyrolactones are obtained through a gold‐catalyzed cyclization/rearrangement cascade reaction.
ChemInform Abstract: Asymmetric Pauson—Khand‐Type Reactions of 1,6‐Enynes Using Formaldehyde as a Carbonyl Source by Cooperative Dual Rhodium Catalysis.
Authors: Furusawa Takuma , Morimoto Tsumoru , Ikeda Keiichi , Tanimoto Hiroki , Nishiyama Yasuhiro , Kakiuchi Kiyomi , Jeong Nakcheol
Published: May 2015

The synthesis of cyclopenta[c]furanones (III) and cyclopenta[c]pyrrolones (V) by the title reaction is accomplished by simultaneous use of neutral and cationic rhodium(I) complexes for efficient cooperative catalysis, which involves neutral rhodium(I)‐catalyzed decarbonylation of formaldehyde (II) and cationic rhodium(I)‐catalyzed cyclocarbonylation of 1,6‐enynes [(I) and (IV)] with the free carbonyl moiety.
ChemInform Abstract: Palladium(0)‐Catalyzed Single and Double Isonitrile Insertion: A Facile Synthesis of Benzofurans, Indoles, and Isatins.
Authors: Senadi Gopal Chandru , Hu Wan‐Ping , Boominathan Siva Senthil Kumar , Wang Jeh‐Jeng
Published: May 2015

A palladium(0)‐catalyzed cascade process consisting of isonitrile insertion and α‐Csp3—H cross‐coupling can be achieved for the synthesis of benzofurans and indoles.
ChemInform Abstract: 2‐(1‐Hydroxypropyn‐2‐yl)‐1‐vinylpyrroles: The First Successful Favorsky Ethynylation of Pyrrolecarbaldehydes.
Authors: Ivanov A. V. , Shcherbakova V. S. , Ushakov I. A. , Sobenina L. N. , Petrova O. V. , Mikhaleva A. I. , Trofimov B. A.
Published: May 2015

The reaction is achieved by the super basic catalytic composition NaOH/EtOH/DMSO.
ChemInform Abstract: Copper(I)‐Catalyzed One‐Pot Synthesis of Highly Functionalized Pyrrolidines from Sulfonyl Azides, Alkynes, and Dimethyl 2‐(Phenylamino)maleate.
Authors: Ramanathan Devenderan , Pitchumani Kasi
Published: May 2015

This cascade reaction consists of an azide—alkyne [3 + 2] cycloaddition/ring rearrangement, ketenimine formation, an intermolecular nucleophilic addition sequence and subsequent intramolecular cyclization followed by [1,3]‐H shift.
ChemInform Abstract: Preparation of 3‐Sulfonylated 3,3‐Disubstituted Oxindoles by the Addition of Sulfinate Salts to 3‐Halooxindoles.
Authors: Zuo Jian , Wu Zhi‐Jun , Zhao Jian‐Qiang , Zhou Ming‐Qiang , Xu Xiao‐Ying , Zhang Xiao‐Mei , Yuan Wei‐Cheng
Published: May 2015

The title reaction is catalyzed by K3PO4.
ChemInform Abstract: A New Synthesis of Indoles via Intramolecular Cyclization of o‐Alkynyl N,N‐Dialkylanilines Promoted by KOt‐Bu/DMSO.
Authors: Chen Yan‐yan , Chen Jia‐hua , Zhang Niu‐niu , Ye Lin‐miao , Zhang Xue‐Jing , Yan Ming
Published: May 2015

It is suggested, that a DMSO radical generated in tBuOK/DMSO systems works as the crucial initiator for the title cyclization process.
ChemInform Abstract: A Highly Efficient Approach to Unnatural Amino‐Acids Containing 3‐Hydroxyoxindole Skeleton via a One‐Pot, Three‐Component Procedure.
Authors: Huang Huang , Xu Yong , Mao Fei , Zhu Jin , Jiang Hualiang , Li Jian
Published: May 2015

The reaction is conducted under catalyst free conditions with high atom economy.
ChemInform Abstract: Synthesis of Indoles via Dehydrogenative N‐Heterocyclization by Supported Platinum Catalysts.
Authors: Moromi Sondomoyee Konika , Touchy Abeda Sultana , Hakim Siddiki S. M. A. , Ali Md. Ayub , Shimizu Ken‐ichi
Published: May 2015

Platinum supported on Nb2O5 or zeolite HBEA‐500 are found to be effective heterogeneous catalysts for the synthesis of indoles via acceptorless dehydrogenative cyclization of 2‐(2‐aminophenyl)ethanol.
ChemInform Abstract: Utilizing Mor‐DalPhos/Palladium‐Catalyzed Monoarylation in the Multicomponent One‐Pot Synthesis of Indoles.
Authors: Rotta‐Loria Nicolas L. , Borzenko Andrey , Alsabeh Pamela G. , Lavery Christopher B. , Stradiotto Mark
Published: May 2015

Two classes of transformation, Buchwald—Hartwig amination and ketone mono‐α‐arylation, are combined to an one‐pot, multicomponent protocol in an inert atmosphere in presence of a diadamantyl‐phosphorus catalyst.
ChemInform Abstract: Silver(I)‐Mediated C—H Amination of 2‐Alkenylanilines: Unique Solvent‐Dependent Migratory Aptitude.
Authors: Youn So Won , Ko Tae Yun , Jang Min Jung , Jang Su San
Published: May 2015

The amination protocol for the synthesis of substituted indoles from 2‐ alkenylanilines is highly effective.
ChemInform Abstract: A Novel Fischer Pseudo‐Benzylic Decarboxylation Approach to the 1,2,3,4‐Tetrahydro‐cyclopenta[b]indol‐3‐yl System.
Authors: Garrido Montalban Antonio , Ma You‐An , Johannsen Steve , Tandel Sagun , Martinelli Michael J.
Published: May 2015

A three step sequence including Fisher indolization of cyclopentanones (II), hydrolysis, and pseudo‐benzylic decarboxylation is presented for the synthesis of the title system.
ChemInform Abstract: Nano Copper and Cobalt Ferrites as Heterogeneous Catalysts for the One‐Pot Synthesis of 2,4,5‐Tri Substituted Imidazoles.
Authors: Sanasi Paul Douglas , Santhipriya D. , Ramesh Y. , Kumar M. Ravi , Swathi B. , Rao K. Jaya
Published: May 2015

A simple one‐pot synthesis is presented for the synthesis of trisubstituted imidazoles using magnetic recyclable spinel nano copper and cobalt ferrites by the condensation of benzil, different aromatic aldehydes, and ammonium acetate in ethanol.
ChemInform Abstract: The Rapid Synthesis of Oxazolines and Their Heterogeneous Oxidation to Oxazoles under Flow Conditions.
Authors: Gloeckner Steffen , Tran Duc N. , Ingham Richard J. , Fenner Sabine , Wilson Zoe E. , Battilocchio Claudio , Ley Steven V.
Published: May 2015

2‐Aryl, hetaryl, alkenyl, and alkyl substituted oxazolines are prepared and oxidized to the corresponding oxazole derivatives.
ChemInform Abstract: Synergistic Catalysis: Enantioselective Addition of Alkylbenzoxazoles to Enals.
Authors: Meazza Marta , Ceban Victor , Pitak Mateusz B. , Coles Simon J. , Rios Ramon
Published: May 2015

The reaction proceeds with low diastereoselectivity and all products are isolated as mixtures of diastereomers.
ChemInform Abstract: An Enolate‐Mediated Organocatalytic Azide‐Ketone [3 + 2]‐Cycloaddition Reaction: Regioselective High‐Yielding Synthesis of Fully Decorated 1,2,3‐Triazoles.
Authors: Shashank Adluri B. , Karthik S. , Madhavachary R. , Ramachary Dhevalapally B.
Published: May 2015

The presented approach tolerates various functional group, thus offering a high‐yielding, regioselective access to a library of 1,2,3‐triazoles most of which have hitherto not been achievable by established methods.
ChemInform Abstract: A Novel and Facile Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles from Benzylic Alcohols Through a One‐Pot, Three‐Component System.
Authors: Gonzalez‐Calderon Davir , Santillan‐Iniesta Itzel , Gonzalez‐Gonzalez Carlos A. , Fuentes‐Benites Aydee , Gonzalez‐Romero Carlos
Published: May 2015

DBU promoted [3 + 2] cycloaddition of in situ generated azides and enolates gives highly functionalized triazoles under mild conditions.
ChemInform Abstract: CAN Catalyzed One‐Pot Synthesis and Docking Study of Some Novel Substituted Imidazole Coupled 1,2,4‐Triazole‐5‐carboxylic Acids as Antifungal Agents.
Authors: Nikalje Anna Pratima G. , Ghodke Mangesh S. , Kalam Khan Firoz A. , Sangshetti Jaiprakash N.
Published: May 2015

Some of the new compounds are found to be equipotent to fluconazole against Candida albicans, e.g. (IVd), (IVg), or show higher activity against Streptococcus pneumonia, Escherichia coli, and Streptococcus pyogenes, compared to ampillicin, e.g. (IVa), (IVe), and (IVf).
ChemInform Abstract: Copper Nanoparticles Generated from Aggregates of a Hexarylbenzene Derivative: A Reusable Catalytic System for ′Click′ Reactions.
Authors: Kaur Sharanjeet , Bhalla Vandana , Kumar Manoj
Published: May 2015

The new hexarylbenzene derivative (HAB) serves as stabilizer of in‐situ formed copper nanoparticles with high catalytic activity to perform alkyl‐azide click reaction under solvent free conditions.
ChemInform Abstract: 4‐(Succinimido)‐1‐butane Sulfonic Acid as a Broensted Acid Catalyst for Synthesis of Pyrano[4,3‐b]pyran Derivatives under Solvent‐Free Conditions.
Authors: Khaligh Nader Ghaffari
Published: May 2015

The title sulfonic acid (SBSA) efficiently catalyzes the three‐component reaction of 4‐hydroxypyranone (I), aromatic aldehydes, and malonitrile furnishing pyranopyran derivatives (IV) (14 examples) in good yield, in general.
ChemInform Abstract: Solvent‐Free and One‐Pot Synthesis of Trisubstituted Methanes Containing Coumarin Catalyzed by Yttrium(III) Nitrate.
Authors: Khodabakhshi Saeed , Shahamirian Mozhgan , Baghernejad Mojtaba
Published: May 2015

Yttrium(III) nitrate is a safe and powerful catalyst for the synthesis of the title compounds (IV) by reaction of 4‐hydroxycoumarin with aryl glyoxals and benzamide under solvent‐free conditions.
ChemInform Abstract: Synthesis of Coumarin‐3‐carboxylic Esters via FeCl3‐Catalyzed Multicomponent Reaction of Salicylaldehydes, Meldrum′s Acid and Alcohols.
Authors: He Xinwei , Shang Yongjia , Zhou Yao , Yu Zhiyu , Han Guang , Jin Wenjing , Chen Jiaojiao
Published: May 2015

Title compounds [(IV) and (VI)] are synthesized using an environmentally friendly and highly atom‐economic procedure and readily available educts.
ChemInform Abstract: Iron‐Catalyzed Alkenylation of Isochroman Acetals with Simple Alkenes.
Authors: Qian Bo , Qiao Cuifang , Xie Yinjun , Huang Hanmin
Published: May 2015

Iron(III) p‐toluenesulfonate is found to be an efficient and inexpensive catalyst for the nucleophilic addition of alkenes to 1‐methoxyisochromans under redox‐neutral conditions.
ChemInform Abstract: Direct and Metal‐Free Arylsulfonylation of Alkynes with Sulfonylhydrazides for the Construction of 3‐Sulfonated Coumarins.
Authors: Wei Wei , Wen Jiangwei , Yang Daoshan , Guo Mengyuan , Wang Yingying , You Jinmao , Wang Hua
Published: May 2015

A series of 3‐sulfonated coumarins is readily prepared by Bu4NI‐catalyzed oxidative arylsulfonylation of alkynes.
ChemInform Abstract: A Facile One‐Pot Synthesis of 2‐(2‐Pyridyl)quinolines via Povarov Reaction.
Authors: Ribeiro Borel Carmindo , Almeida Barbosa Luiz Claudio , Alvares Maltha Celia Regina , Fernandes Sergio Antonio
Published: May 2015

The title reaction starts from anilines, hetaryl aldehydes, and ethyl vinyl ether and is incompatible with sterically hindered or halogen‐containing anilines.
ChemInform Abstract: N‐Bromosuccinimide‐Mediated Radical Cyclization of 3‐Arylallyl Azides: Synthesis of 3‐Substituted Quinolines.
Authors: Wang Wei‐Xia , Zhang Qing‐Zhao , Zhang Tian‐Qi , Li Zhan‐Shan , Zhang Wei , Yu Wei
Published: May 2015

Under visible light irradiation of N‐bromosuccinimide methyl 2‐(azidomethyl)‐3‐aryl‐propenoates and ‐acrylonitriles convert to the corresponding iminyl radicals which undergo intramolecular ortho attack on the aryl ring, affording methyl quinoline‐3‐carboxylates and 3‐carbonitriles, respectively.
ChemInform Abstract: An Expedient Approach to 1,2‐Dihydroisoquinoline Derivatives via Cobalt Catalyzed 6‐endo dig Cyclization Followed by Mannich Condensation of o‐Alkynylarylaldimines.
Authors: Urvashi Urvashi , Rastogi Gaurav K. , Ginotra Sandeep K. , Agarwal Alka , Tandon Vibha
Published: May 2015

A Co‐catalyst for the direct addition of nitromethane (II) to imines (I) furnishing 1,2‐dihydroisoquinolines (III) is reported.
ChemInform Abstract: Diastereoselective Palladium‐Catalyzed Arylcyanation/Heteroarylcyanation of Enantioenriched N‐Allylcarboxamides.
Authors: Yoon Hyung , Petrone David A. , Lautens Mark
Published: May 2015

The title reaction affords neopentyl nitrile‐containing dihydroisoquinolinone products such as (III), (V), (VII), and (IX) in high yields and diastereoselectivities with full preservation of enantioenrichment.
ChemInform Abstract: Iron‐Mediated Carboarylation/Cyclization of Propargylanilines with Acetals: A Concise Route to Indeno[2,1‐c]quinolines.
Authors: Yang Qin , Xu Tongyu , Yu Zhengkun
Published: May 2015

The formation of N‐tosyldihydroindenoquinoline derivatives is mediated by a catalytic or stoichiometric amount of iron trichloride, whereas the formation of indenoquinolines requires excess amounts of iron trichloride or bromide, respectively.
ChemInform Abstract: Highly Enantioselective Intramolecular 1,3‐Dipolar Cycloaddition: A Route to Piperidino‐Pyrrolizidines.
Authors: Vidadala Srinivasa Rao , Golz Christopher , Strohmann Carsten , Daniliuc Constantin‐G. , Waldmann Herbert
Published: May 2015

A highly enantioselective synthesis of natural‐product‐inspired pyrrolidino‐piperidines by means of an intramolecular 1,3‐dipolar cycloaddition with azomethine ylides is reported.
ChemInform Abstract: Cyclohexane‐Fused Pyridine Derivatives with Photophysical Properties: Synthesis by “Three‐Component” Domino Reaction and Structural Optimization by DFT Calculations.
Authors: Guo Cheng , Wang Jianqiang , Li Ziping , Wang Xinzhi , Zhou Yixin
Published: May 2015

The photophysical properties of the products are investigated in EtOH.
ChemInform Abstract: Visible‐Light‐Driven Electrocyclization of Activated Allylic Amines via Azomethine Ylide Formation.
Authors: Yadav Arvind K. , Yadav Lal Dhar S.
Published: May 2015

The method serves for the synthesis of substituted tricyclic N‐heterocycles.
ChemInform Abstract: Synthesis, Antimycobacterial and Antifungal Evaluation of Some New 1‐Ethyl‐5‐ (hetero)aryl‐6‐styryl‐1,6‐dihydropyrazine‐2,3‐dicarbonitriles.
Authors: Verbitskiy Egor V. , Slepukhin Pavel A. , Kravchenko Marionella A. , Skornyakov Sergey N. , Evstigneeva Natal'ya P. , Kungurov Nikolay V. , Zil'berberg Natal'ya V. , Rusinov Gennady L. , Chupakhin Oleg N. , Charushin Valery N.
Published: May 2015

A series of title compounds of type (III), (V), and (VI) are prepared and screened for their antimycobacterial and antifungal activities.
ChemInform Abstract: One‐Pot Synthesis of 2‐Arylquinazolines and Tetracyclic Isoindolo[1,2‐a]quinazolines via Cyanation Followed by Rearrangement of ortho‐Substituted 2‐Halo‐N‐arylbenzamides.
Authors: Gawande Sachin D. , Zanwar Manoj R. , Kavala Veerababurao , Kuo Chun‐Wei , Rajawinslin R. R. , Yao Ching‐Fa
Published: May 2015

The base‐catalyzed one‐pot reaction of 2‐halo‐N‐arylbenzamides with CuCN furnishes 2‐arylquinazolines or tetracyclic isoindoloquinazolines in DMSO at 135°C or dioxane at 101°C, respectively.
ChemInform Abstract: Ultrasound‐Mediated One‐Pot Synthesis of 7‐Methyl‐Substituted Pyrido[4,3‐d]pyrimidine Scaffolds by a Catalyst‐Free Protocol.
Authors: Sarmah Manas M. , Prajapati Dipak
Published: May 2015

The reaction succeeds using aryl aldehydes as the reaction partner, but fails with alkyl aldehydes and phenyl glyoxal derivatives.