bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of the Acyl Side Chain on Pyrene Excimer Formation as a Model for Asphaltene Aggregation
Authors: D. S. de Alvarenga Suyane , J. Garden Simon , S. B. Forero Josué , S. P. Teixeira Raquel , S. Souza Rodrigo , M. H. Gonçalves Yan , A. C. Horta Bruno , A. G. Gomez Javier , C. dos Santos Luiz H. , S. Ribeiro Emerson , J. Corrêa Rodrigo
Published: October 2024

Asphaltene aggregation mechanism is still a nebulous and controversial issue. Many authors argue that the aggregation of its components is due to p-stacking interactions, nonetheless, alkyl chains, heteroatoms, and even acidic groups are also constituents of asphaltenes and can play an important role in the chemistry of asphaltene. Excimers from pyrene are easily detected by fluorescence and were used in the current study to probe the effect of the side chain on the p-stacking capacity of pyrene. Pyrene was acylated with acyl chains varying from two to twelve carbon atoms, and the effect of the variation of the acyl chain length on excimer formation was followed by fluorescence emission spectroscopy. The results revealed that as the side chain grows from two to twelve carbon atoms the excimer/monomer ratio decreases and the excimer heat of formation drops from DH = -6.00 to -1.29 kcal mol-1. Further, the crystal structure of octanoyl pyrene (PC8) indicates that in the crystal structure, the aromatic moiety faces the acyl chain. This result was corroborated by density functional theory (DFT) calculations. Finally, the results were compared with two different asphaltenes and indicate that p-stacking cannot be assumed as the main driving force for asphaltene aggregation.
Anticancer Drug Discovery from Natural Compounds Targeting PI3K/AKT/mTOR Signaling Pathway
Authors: da Silva Manuele Figueiredo , Lins Arestides Alves , Gomes Midiane Correia , Marinho Washley Phyama de Jesus , de Araújo Rodrigo Santos Aquino , de Moura Ricardo Olimpio , Zhan Peng , Nascimento Igor José dos Santos , da Silva-Júnior Edeildo Ferreira
Published: October 2024

The term cancer is used to describe a complex pathology characterized by the
uncontrollable proliferation of cells, which displays a fast metastatic spread, being a disease
with difficult treatment. In this context, Phosphatidylinositol 3-kinase (PI3K) represents
a promising pathway to be inhibited, aiming to develop anticancer agents, since it
performs a pivotal role in regulating essential cellular processes, including cell proliferation,
growth, autophagy, and apoptosis. In parallel, natural compounds can effectively
represent a therapeutic strategy to fight against malignant cells. Then, compounds derived
from various plant sources, such as flavonoids, terpenoids, alkaloids, coumarins,
and lignans, have exhibited remarkable in vitro and in vivo anticancer properties. This review
focused in the exploration of natural products targeting the PI3K/AKT/m-TOR signaling
pathway, demonstrating that these compounds could even further investigated to
reveal novel and effective anticancer drugs in the future.
Discovery of 5-(Substituted Phenyl)-2-aryl Benzimidazole Derivatives as SIRT1 Activators: Their Design, in silico Studies, Synthesis, and in vitro Evaluation
Authors: Chauhan Shilpi , Kumar Ashwani , Kumar Rajnish , Saini Deepika
Published: October 2024

Aim:

Silent information regulator two homologue one (SIRT1) is an emerging
target for managing metabolic disorders. This study aimed to synthesize novel 5-(-
substituted phenyl)-2-aryl benzimidazole derivatives and evaluate them for SIRT1 activation.

Methods:

The compounds were designed according to the findings of the QSAR models
framed in our previous studies. Molecular docking and dynamics studies were also performed
to explore the interactions of designed compounds with the active site of the
SIRT1 enzyme using AutoDock Vina and Schrödinger Maestro version 11.8.012, respectively.
Compounds with good binding affinity were synthesized by Suzuki-Miyaura
cross-coupling and spectrally characterized. The molecules were evaluated for their in
vitro SIRT1 activation properties using a fluorescent screening kit. Based on the results
of in vitro assay, a structure-activity relationship was established. SwissADME was employed
to calculate the pharmacokinetics characteristics of the synthesized molecules.

Results:

The molecular docking studies revealed that all the activators were effectively
docked in the catalytic active site. All compounds demonstrated interactions with important
amino acids like Glu230 and Arg446. In molecular dynamics simulations, the root
mean square deviation (RMSD) of compound 5m and protein SIRT1 remained stable,
i.e., below 3mm. Compound 5m, 4-(2-(3,4-dihydroxy-5-nitrophenyl)-1H-benzo[d]imidazol-
5-yl)benzaldehyde, was the most potent compound with an EC50 value of 0.006 mM
(±0.001) and maximum activation of 240.5%. All the synthesized compounds had acceptable
theoretical ADME profiles, and drug-likeness properties complied with Lipinski’s
rule.

Conclusion:

According to the findings, synthesized compounds may be viable leads for
SIRT1 activators and may be used to advance preclinical in vivo research utilizing animal
models.
Nanoparticle-Mediated Transcytosis in Tumor Drug Delivery: Mechanisms, Categories, and Novel Applications
Authors: Doaa Nakaooh , Detorgma Signa Lon Rolande , Yang Kaiyun , Salama Rajae , Zhang Wenli
Published: October 2024

The development of nanotechnology-based drug delivery systems has been extensively
investigated across various therapies, leading to the creation of numerous nanomedicines for clinical
use. However, these nanomedicines have yet to achieve the anticipated therapeutic efficacy in
clinical settings, highlighting the urgent need for further research in this area. A primary challenge
in nanomedicine research lies in ensuring that nanoparticles and therapeutic agents can effectively
penetrate and accumulate within tumors. The enhanced permeability and retention (EPR) effect
has been previously explored as a means to enhance drug delivery to tumors, but recent findings
have revealed its limitations, including variable responses, restricted penetration, clearance by the
reticuloendothelial system, and non-specific accumulation. As an alternative approach, transcytosis
has been explored for delivering drugs to specific organs or tissues, potentially bypassing some
of the constraints of the EPR effect. For example, nanoparticles can be guided through barriers by
targeting specific receptors on cell surfaces or by utilizing a different charge compared to tumor
cells' surfaces. Therefore, this article explores transcytosis, including adsorptive, receptor-mediated,
and cell-mediated subtypes, all of which have demonstrated promising results and offer potential
solutions to enhance the effectiveness of nanomedicine delivery for cancer therapy.
Comparative Clinical, Proteomic, and Serologic Evaluation in Non-Hospitalized COVID-19 Patients and Healthy Individuals
Authors: Alihosseini Solmaz , Zali Hakimeh , Majd Ahmad , Movahedi Monireh , Abdollahi Hamed
Published: October 2024

Introduction:

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a
significant global impact since its declaration as a public health emergency in January 2020. Symptoms
of COVID-19 can range from mild to severe, including fever, cough, fatigue, and shortness of
breath. This study aimed to investigate the clinical symptoms and proteomic differences between
non-hospitalized COVID-19 patients and healthy individuals.

Method:

Clinical data of 6231 COVID-19 patients of different age groups and sexes were collected
and analyzed. Proteins were separated by SDS-PAGE and identified by MALDI-TOF. 900 serum
samples were collected, with 100 samples per patient group and one healthy control group.

Result:

In the control group of healthy individuals, five proteins (HAPTO, IGKC, FUT10, CO3,
SESQ2) were expressed with a score of 1+, serving as a reference for the other groups. Group 9,
consisting of individuals who had recovered (IgG positive), showed negative results for all five proteins
due to anti-IgG antibody production in memory cells. The significant differences in protein
expression compared to the control group indicated up-regulation and down-regulation of these proteins.
Positive PCR or IgG and IgM results led to notable differences in protein expression across
all studied groups.

Conclusion:

The altered protein expression in infected individuals compared to healthy controls
may suggest the potential for these proteins to serve as biomarkers for disease diagnosis and prognosis.
Microwave-assisted Extraction and Quantification of Triterpene Acids from Davilla rugosa and Eriope blanchetii-+
Authors: Cunha André B. , David Jorge M. , Cunha Silvio , Santos Rauldenis A.F.
Published: October 2024

Aims:

This study describes the development of methodologies for the isolation, identification,
and quantification of betulinic, oleanolic, and ursolic acids in extracts from Eriope blanchetii
(Lamiaceae) and Davilla rugosa (Dilleniaceae).

Background:

Betulinic, oleanolic, and ursolic acids are compounds with biological activities and
commercial and technological uses. Developing methodologies for their separation from natural
sources are relevant once their synthesis is not easy.

Objectives:

Development of conventional methodology for quantifying and isolating pure betulinic
acid in chloroform extracts of D. rugosa stems and developing methods for obtaining and quantifying
oleanolic, ursolic, and betulinic acids from organic extracts.

Method:

A complete validation "in-house" for the chromatographic method was performed, and
different techniques of extraction – maceration under heating vs. microwave-assisted extraction
(MAE) conditions were compared. Davilla rugosa stems were employed as the source of pure betulinic
acid, and this compound was obtained in a reasonable yield (~ 2.4 x 10-2 % dry weight).

Results:

Chromatographic analysis of the E. blanchetii extracts indicates betulinic acid occurs in
higher concentrations in the leaves (5.53% dry weight), followed by lower concentrations in other
plant parts, together with two other triterpene acids. HPLC analysis of extracts obtained by MAE
extractions and maceration of E. blanchetti indicated that MAE is more efficient than maceration
under heating in relative yield. The HPLC-validated method was rightly selective and accurate, presenting
good linearity (R2 = 0.9993), robustness, and recovery rate values with acceptable limits (LD
= 5.9914; LQ = 18.1557; μg mL-1).

Conclusion:

MAE was the most efficient methodology than maceration under similar conditions.
Furthermore, different parts of E. blanchetii and D. rugosa are affordable sources of bioactive betulinic
acid.
Analysis and Classification of Medical Images Using Deep Learning Algorithms
Authors: Karima Chouchene , Bourbia Nadjla , Messaoudi Kamel , Bourennane El-Bay
Published: October 2024

Introduction:

Nowadays, Artificial intelligence and machine learning have emerged
as a powerful tool for the analysis of medical images such as MRI scans. This technology
holds significant potential to improve diagnostic services and accelerate medical advances by
facilitating clinical decision-making.

Method:

In this work, we developed a Convolutional Neural Network (CNN) model specifically
designed for the classification of medical images. Using a selected database, the model
achieved a classification accuracy of 92%. To further improve the performance, we leveraged
the pre-trained VGG16 model, which increased the classification accuracy to 100%. Additionally,
we preprocessed the MRI images using the Roboflow platform and then developed
YOLOv5 models for the detection of tumors, infections, and cancerous lesions.

Result:

The results demonstrate a localization accuracy of 50.41% for these medical conditions.

Conclusion:

This research highlights the value of AI-driven approaches in enhancing medical
image analysis and their potential to support more accurate diagnoses and accelerate advancements
in healthcare.
KÄSTNER'İN UÇAN SINIF ESERİNİ LİDERLİK EĞİTİMİ BAĞLAMINDA OKUMAK
Authors: Bilgen Mustafa
Published: October 2024

Okuma yeterliliği ile kazanılan üst düzey bilişsel ve duyuşsal edinimler, çocukların dil yetisini, eylemlerini ve kendi kaderini tayin etmesini etkiler ve davranışa dönüşür. Okuma yerliliğine sahip okurlar okuma eylemi ile eğitim de almış olurlar. Çalışmada Kästner'in Uçan Sınıf adlı eseri liderlik eğitimi bağlamında okunması amaçlanmıştır. Alt problem olarak Uçan Sınıf adlı eserde lider karakterlerin Northouse’un liderlik özelliklerinden hangilerine sahip olduklarını tespit etmektir. Araştırmada nitel araştırma yöntemlerinden doküman analizi kullanılmıştır. Çalışmanın verileri Northouse’un liderlik özelliklerinden; zekâ, özgüven, kararlılık, dürüstlük ve cesaretlilik özelliklerinden oluşturulan veri toplama formuyla toplanmıştır. Toplanan veriler betimsel analize göre analiz edilmiştir. Bulgularda ana kahraman olan Martin Thaler’in zekâ, özgüven, kararlılık, dürüstlük ve cesaretlilik özelliklerine sahip olduğu tespit edilmiştir. Rakibi ortaokul öğrencilerinin lideri Egerland’ın ise sadece cesaret, özgüven ve dürüstlük lider özelliklerine sahip olduğu tesbit edilmiştir. Okul romanı okuma yeterliği çerçevesinde okunduğunda Martin Thaler’in tüm liderlik özelliklerini kişiliğinde bulundurması onun liderliğinin etkili, başarılı ve iyi olmasına neden olduğu anlaşılmaktadır. Egerland’ın ise zeki olmayışı, yeterince cesaret ve kararlı olmayışı onun liderliğinin başarısız olmasına neden olduğu anlaşılmaktadır. Sonuç olarak okuma yeterliliğine sahip çocuk, okuma yoluyla bir liderin sahip olması gereken liderlik özelliklerinin neler olduğunu, edebi metin üzerinden sunulan gerçekçi yaşam kesitleri üzerinden öğrenmiş olabilecektir. Erich Kästner’in Uçan Sınıf adlı okul romanındaki lider karakterler farklı liderlik özellikleri açısından incelenebilir.
The Role of Indonesia’s National Health Insurance Cadre: A Case Study in Bali
Authors: Indrayathi Putu Ayu , Prameswari Agung Ratih Surya Prameswari , Kolozsvari Laszlo Robert
Published: October 2024

The management of informal sector participants poses the most significant difficulty to universal coverage attempts throughout Indonesia's National Health Insurance era. As a result, in April 2017, BPJS Kesehatan established the JKN Cadre Program. This program intends to expand the number of participants while also improving the collectability of contributions from the informal sector. This study aims to investigate the role of the cadre and explore the supporting, and inhibiting factors of such a program. This study is a qualitative descriptive case study, with data gathered through in-depth interviews. Informants were chosen purposefully. Thematic Analysis was utilized to examine the data, which Source Triangulation subsequently confirmed. The study found that the JKN KIS cadre has five functions, the most important of which is to remind people and collect contributions. Cadre activities included education and outreach, as well as collecting payment arrears receipts. The study also identified three inhibiting and supportive elements for the role of cadre namely individual, environmental, and organisational factors. To reduce unfavourable perceptions of JKN-KIS, it is vital to increase cadre self-actualization, self-esteem, information dissemination, synergy, and quality.
Assessing the impact of interactive multimedia learning platforms on dance education outcomes
Authors:   Faculty of Social Sciences and Liberal Arts, UCSI University, Kuala Lumpur, Malaysia, Xuan Yin , Della Christiantine ,   Faculty of Social Sciences and Liberal Arts, UCSI University, Kuala Lumpur, Malaysia
Published: October 2024

This study examined the use of interactive multimedia learning platforms in dance education, guided by the Technology Acceptance Model (TAM) and Self-Efficacy Theory. The research used Structural Equation Modelling (SEM) with a random sample of 362 students from four schools in Beijing. It aimed to explore the relationship between perceived usefulness (PU), perceived ease of use (PEOU), attitudes towards these platforms, and the impact of self-efficacy on performance and learning. The results showed that PU and PEOU significantly improved students' attitudes, which in turn enhanced their self-efficacy and performance. The study suggests that multimedia platforms are more effective than traditional teaching methods in improving learning outcomes, engagement, and satisfaction in dance education. These findings contribute to the growing body of research on educational technology in the arts, highlighting the importance of integrating technological advancements with psychological factors when developing digital learning environments. This study stands out by combining TAM with Self-Efficacy Theory in the context of dance education, providing a comprehensive understanding of the cognitive and emotional factors that affect technology acceptance and learning outcomes. It addresses the challenges and benefits of using multimedia in a physically demanding field like dance, which has not been extensively researched. However, the study is limited by its focus on a specific region and demographic group. Future research should include a broader range of participants to ensure the findings are applicable to various contexts. Despite some limitations, this study offers valuable insights for designing more effective multimedia-based learning systems for dance and other fine arts.
A Texting- and Internet-Based Self-Reporting System for Enhanced Vaccine Safety Surveillance With Insights From a Large Integrated Health Care System in the United States: Prospective Cohort Study
Authors: Malden Debbie E , Gee Julianne , Glenn Sungching , Li Zhuoxin , Ryan Denison S , Gu Zheng , Bezi Cassandra , Kim Sunhea , Jazwa Amelia , McNeil Michael M , Weintraub Eric S , Tartof Sara Y
Published: October 2024

Background

SMS text messaging- and internet-based self-reporting systems can supplement existing vaccine safety surveillance systems, but real-world participation patterns have not been assessed at scale.

Objective

This study aimed to describe the participation rates of a new SMS text messaging- and internet-based self-reporting system called the Kaiser Permanente Side Effect Monitor (KPSEM) within a large integrated health care system.

Methods

We conducted a prospective cohort study of Kaiser Permanente Southern California (KPSC) patients receiving a COVID-19 vaccination from April 23, 2021, to July 31, 2023. Patients received invitations through flyers, SMS text messages, emails, or patient health care portals. After consenting, patients received regular surveys to assess adverse events up to 5 weeks after each dose. Linkage with medical records provided demographic and clinical data. In this study, we describe KPSEM participation rates, defined as providing consent and completing at least 1 survey within 35 days of COVID-19 vaccination.

Results

Approximately, 8% (164,636/2,091,975) of all vaccinated patients provided consent and completed at least 1 survey within 35 days. The lowest participation rates were observed for parents of children aged 12-17 years (1349/152,928, 0.9% participation rate), and the highest participation was observed among older adults aged 61-70 years (39,844/329,487, 12.1%). Persons of non-Hispanic White race were more likely to participate compared with other races and ethnicities (13.1% vs 3.9%-7.5%, respectively; P<.001). In addition, patients residing in areas with a higher neighborhood deprivation index were less likely to participate (5.1%, 16,503/323,122 vs 10.8%, 38,084/352,939 in the highest vs lowest deprivation quintiles, respectively; P<.001). Invitations through the individual's Kaiser Permanente health care portal account and by SMS text message were associated with the highest participation rate (19.2%, 70,248/366,377 and 10.5%, 96,169/914,793, respectively), followed by email (19,464/396,912, 4.9%) and then QR codes on flyers (25,882/2,091,975, 1.2%). SMS text messaging–based surveys demonstrated the highest sustained daily response rates compared with internet-based surveys.

Conclusions

This real-world prospective study demonstrated that a novel digital vaccine safety self-reporting system implemented through an integrated health care system can achieve high participation rates. Linkage with participants’ electronic health records is another unique benefit of this surveillance system. We also identified lower participation among selected vulnerable populations, which may have implications when interpreting data collected from similar digital systems.
AI-Based Malware Detection and Classification for Wireless Networks
Authors: Tripathi Dr. Diwakar Ramanuj , Kumbhare Aditi Achal , Kushwaha Bhupendra Ramrup
Published: October 2024

Abstract: This study highlights the shortcomings of conventional detection strategies like signature-based and anomaly-based approaches by examining the application of artificial intelligence (AI) techniques for malware detection and classification in wireless networks. Using machine learning and deep learning algorithms, the study shows notable gains in false positive rates, detection accuracy, and adaptation to changing threats. The acquisition of data from many sources, the extraction of features from malware samples, and the thorough training and assessment of models are important techniques. The results demonstrate how successful AI-based systems are in detecting and reducing malware threats, even in the face of issues like dataset variety and interpretability. The potential of AI technology to improve cybersecurity measures in wireless environments is highlighted by this research.
Improving Legal Regulation in the Field of Reducing Greenhouse Gas Emissions in the Russian Federation
Authors: Kotova E. V.
Published: October 2024

Carbon regulation in Russia is at the stage of formation, which requires the development of an integrated approach based on the principles of sustainable development, taking into account international experience. With an understanding of the importance of the problem of climate change for the future of the country and the entire planet, as well as in fulfillment of international obligations, Russia has adopted a number of measures to nationally regulate greenhouse gas emissions reduction, as well as other mechanisms that help slow down global changes.

The purpose of this article is to develop comprehensive legal solutions to optimize the system of regulatory legal regulation of issues of reducing greenhouse gas emissions. The research problem lies in the formation of such mechanisms of state climate regulation, which, on the one hand, will contribute to achieving the goals of reducing greenhouse gas emissions set by Russia, and on the other hand, will correspond to the current foreign policy challenges, the ambiguous geopolitical and difficult economic situation that affect public policy, the business community and the global interaction on climate issues.
Compulsory and Voluntary Biometrics: Content and Distinction in Russian Law
Authors: Mitianov Z. O.
Published: October 2024

The article examines the peculiarities of separation and differentiation of two areas included in the sphere of biometric personal data processing in Russia: compulsory and voluntary biometrics. The definitions of the concepts of these areas are formulated, the peculiarities of their content are considered. Justification of their differentiation, main criteria and specifics of such differentiation are given. The problems of voluntary biometrics in the context of exceptional cases of compulsory processing of biometric personal data are highlighted. The balance of private and public interests in each of the areas is studied. The conclusions are drawn about the formation of the scope of voluntary biometrics and its differentiation from compulsory biometrics due to the legislative novelties at the end of 2022; the essential difference between compulsory biometrics and voluntary biometrics; the existence of special criteria for differentiating between voluntary and compulsory biometrics; the need to focus lawmaking efforts on voluntary biometrics due to its dynamism and closeness to everyday life.
breve história do estudo dos fármacos e os ganhadores do Nobel
Authors: Ferro Emer Suavinho , Reis Ricardo , Freitas Hércules Rezende
Published: October 2024

Quando se ensina farmacologia aos estudantes de cursos de graduação como medicina, enfermagem, odontologia, medicina veterinária, farmácia, nutrição, educação física, ciências biomédicas, entre outros, nos deparamos com desafios didáticos. O primeiro é decidir quais os conceitos devem ser apresentados, diante de um conhecimento tão vasto adquirido ao longo de mais de um século. Não podem faltar conceitos históricos e primários de interação droga-receptor (agonista, antagonista e curva dose-resposta), a partir dos quais toda farmacologia emerge. É importante que os estudantes compreendam a farmacologia básica como fruto de interações atômicas entre o fármaco e o alvo terapêutico, uma disciplina que interage com muitas outras como a química medicinal, biologia, fisiologia, bioquímica e biologia estrutural. Uma frase mencionada por Earl Sutherland a Alfred Goodman Gilman (ambos ganhadores do prêmio Nobel) para convencê-lo a se inscrever no programa de doutorado na Vanderbilt University School of Medicine em Nashville, Tennessee, EUA, é a síntese desse artigo; Earl Sutherland disse “farmacologia é a bioquímica com propósito”. Tendo como referência o artigo anterior (1), desenvolvemos um resumo histórico da farmacologia, considerando momentos e descobertas marcantes por dezenas de pesquisadores, que levaram a inúmeros prêmios Nobel; para nós, uma certificação de que aquela informação é um marco histórico. Em síntese, apresentaremos um texto propositivo de como o estudo dos fármacos promove melhoria na qualidade e expectativa de vida da população e, por consequente, gera inovação nas mais diferentes áreas do conhecimento.
Factors influencing the attitude of undergraduate students towards mathematical reasoning: An approach using AMOS-structural equation modelling
Authors: Tak Chan Choon , Zulnaidi Hutkemri , Eu Leong Kwan
Published: October 2024

Studies on mathematics achievement status show that mathematical reasoning in Malaysian education is critical, especially among university students. Students' attitude toward mathematics is affected by affective, behavioural and cognitive factors. The present research investigated the connections between these variables and their impact on individuals' attitudes towards mathematics reasoning. A statistical analysis method, namely, AMOS-Structural Equation Modelling, was used in this approach. The survey method involving 378 university education students around the Klang Valley was selected using a proportional stratified random sampling technique. The respondents must complete the mathematics reasoning assessment and answer the questionnaire consisting of three components: affective, behavioural and cognitive towards mathematics reasoning. AMOS-Structural Equation Modelling (AMOS-SEM) was applied using data obtained from questionnaires. Results demonstrated that the measurement models showed acceptable validity and reliability by removing some indications from the scales. The findings illustrate the relationship between students' attitudes and mathematical reasoning. Moreover, attitude is significantly related to students' mathematical reasoning performance in university education. The next study's recommendation involves an interview session to explore more findings that might impact their learning in mathematical reasoning.
Criação de formas expressivas na estratégia de combate à violência contra a mulher
Authors: Elisa Viviani Ana
Published: October 2024

O intuito deste trabalho é investigar as estratégias de mobilização do espectador para causas como a violência contra a mulher à luz da obra Distant Suffering, de Luc Boltanski. Nela, o autor, que analisa o modo como operam as políticas de piedade, elabora uma fórmula que combina aspectos universais e particulares para a criação de formas expressivas, isto é, músicas, filmes, histórias, a fim de engajar o espectador em uma determinada causa por meio da imaginação. Para isso, recorremos a dois vídeos que tratam do tema. O primeiro foi produzido pela ONU Mulheres em parceria com a Rede Globo em 2020 e o segundo foi produzido no mesmo ano pelo Ministério Público de Santa Catarina. Assim, procuramos compreender se tais vídeos atendem à fórmula delineada por Boltanski e podem, assim, engajar o espectador para a causa apresentada.
Adolescência e necropolítica
Authors: Rodrigues Calebe , Martins Helena
Published: October 2024

O artigo propõe analisar a relação entre televisão, adolescência e necropolítica, a partir do conceito de necropolítica, de Achille Mbembe em diálogo com o conceito de criminologia midiática de Raúl Zaffaroni. Procura-se entender como o programa policialesco Cidade 190, veiculado pela TV Cidade, afiliada à Record no Ceará, constrói narrativas que colaboram para a legitimação de ações políticas que promovem exclusões e, em última instância, determinam quem pode permanecer vivo ou deve morrer. Analisou-se 202 matérias do programa Cidade 190, nos anos de 2018 e 2021, a fim de perceber a recorrência da abordagem sobre adolescentes em associação com atos criminosos. A ênfase nesse grupo social se dá, tendo em vista a alta taxa de mortalidade de adolescentes negros e periféricos no Ceará. A partir da análise dos modos de endereçamento, com ênfase no papel do apresentador como mediador e nos temas abordados, comprovou-se a construção de narrativas violadoras de direitos contra adolescentes vulnerabilizados.
Desinformação contemporânea: herança de guerra
Authors: Bourscheid Ana Paula
Published: October 2024

Com base na pesquisa bibliográfica, este artigo tem como objetivo apresentar um resgate histórico dos usos de práticas desinformativas em períodos de guerra, com destaque para as guerras chinesas, a Segunda Guerra Mundial e a Guerra Fria. Além de verificar as relações dessas práticas com a desinformação contemporânea que circula em ambientes digitais, especialmente nas redes sociais online. Como resultado, verifica-se que a diferença entre as práticas desinformativas herdadas dos períodos de guerra e a desinformação contemporânea está no poder de circulação, no alcance desses conteúdos e no quantitativo de vítimas da desinformação. Vítimas que, em um determinado momento do ciclo desinformativo, também se tornam coautoras da desinformação ao compartilhar e disseminar esses conteúdos em seus perfis pessoais nas redes sociais online. Esse cenário de aumento da desinformação reforça a necessidade da efetivação de ações e políticas públicas voltadas para a educação midiática da população, com ênfase nos usuários das redes sociais online, com a finalidade de qualificar o cidadão para que esteja apto a questionar a autoria e a veracidade dos conteúdos midiáticos consumidos diariamente, bem como realizar a checagem das informações que consome.
La minería de datos para desarrollar una estrategia organizacional eficaz en las universidades
Authors: Ovelar Fernández Walter Daniel , RIVEROS QUINTANA RICARDO IGNACIO
Published: October 2024

Introducción: se realiza una investigación con el propósito de identificar los elementos fundamentales, las partes involucradas y las metas de la educación superior reflejadas en las Declaraciones de Misión (DM) de las universidades de Paraguay, para establecer si se ajustan al modelo desarrollado a partir de investigaciones previas. Metodología: Los datos se colectaron con el análisis de contenido directamente de los sitios web de las 44 universidades seleccionadas y fueron analizados con la minería de datos. Se hizo uso de las teorías y de la señalización para respaldar la presencia de las partes interesadas y de los fines de la educación superior del país en las DM. Resultados: Como resultado se encontró que los elementos, a saber, los estudiantes como parte interesada y los fines de la educación superior, están presentes en un bajo porcentaje en las DM. Estos hallazgos sugieren que existen oportunidades significativas para mejorar la elaboración de las DM de las universidades paraguayas de manera que puedan desarrollar una estrategia organizacional eficaz.
Liderazgo apreciativo empresarial como estrategiade formación en administración y economía
Authors: Aular López Andrés
Published: October 2024

Introducción: en este artículo se investigan las dimensiones del liderazgo apreciativo empresarial desde la perspectiva de los estudiantes (Cooperrider, 2020), (Subirana y Cooperrider, 2013), (Varona, 2022). En esta perspectiva se asume el liderazgo apreciativo como catalizador del cambio y, se analiza el liderazgo floreciente (Vásquez, 2020). cuyas dimensiones de análisis permiten analizar las categorías clave que permiten desarrollar un liderazgo apreciativo en empresas y emprendimientos. Metodología: se analizan las dimensiones del liderazgo empresarial desde la perspectiva que tienen los estudiantes del MBA sobre el liderazgo apreciativo. Esta población se escoge porque se están formando a nivel de posgrado para intervenir en procesos de cambio empresarial. Metodológicamente, se utilizó para los estudiantes un cuestionario construido con base en la escala de Likert, que se procesó en el programa para análisis de datos SPSS (Statistical Package for Social Sciences); así como un aparte cualitativo con dos interrogantes abiertas, procesando categorías con codificación abierta. Resultados: La evidencia empírica demostró la utilidad de las dimensiones del liderazgo apreciativo para describir, analizar los aspectos y categorías que definen las empresas de acuerdo a la visión de los estudiantes.
Shariah governance and audit practices in Islamic co-operatives: An audit expectation-performance gap analysis
Authors: Salleh Supiah , Kamaruddin Muhammad Iqmal Hisham , Shafii Zurina , Hanefah Mustafa Mohd , Zakaria Nurazalia , Mahyudin Wan A’tirah , Sabri Nur Amni Mahmud
Published: October 2024

This study focuses on the inclusion of Shariah governance and audit best practices in Islamic co-operatives in Malaysia. The development of Shariah governance and audit is essential to complement the Shariah compliance mechanisms already in place and practiced internally within these Islamic co-operatives. Strong regulations, frameworks, and guidelines are needed to uphold Shariah compliance practices. The Delphi method was used as the study’s methodology, involving a series of discussions with industry practitioners in Islamic co-operatives. Based on the findings, there is an existing expectation-performance gap in regulations, frameworks, and guidelines; independence and competency; and Shariah audit scope in governing Shariah compliance principles in Islamic co-operatives. This is crucial because well-developed regulations, frameworks, and guidelines in Shariah governance and audit will increase stakeholders’ trust that the activities and operations of Islamic co-operatives are Shariah-compliant. Additionally, providing a standardized framework will help manage risks in Islamic co-operatives and, in the broader context, contribute to the industry’s and the economy’s growth by offering stakeholders adequate information to make informed decisions.
Optimizing Distributed Energy Resources in Microgrid SCUC through Seq2Seq Scheduling Algorithms
Authors: Nishtar Zuhaib , Li NA , Soomro Abdul Razzaque , Afzal Jamil
Published: October 2024

In order to optimize Distributed Energy Resources (DERs) inside a microgrid's Security-Constrained Unit Commitment framework, this study investigates the use of Seq2Seq (Sequence-to-Sequence) scheduling methods (SCUC). There is a growing consensus that microgrids are an important part of the future of the electric grid because of the advantages they provide in terms of reliability, renewable energy integration, and overall efficiency. In the context of complicated SCUC issues, efficient scheduling and optimization of DERs are essential for realizing their full potential. Seq2Seq models, a kind of deep learning approach, have shown impressive performance in several applications requiring sequence prediction. Uncertainty in renewable energy production, energy demand forecasts, and security limitations are all addressed in this work as Seq2Seq algorithms are applied to microgrid SCUC. Significant gains in economic efficiency, ecological viability, and compliance with security constraints have been shown. This study lays the way for the development of more effective, sustainable, and resilient energy infrastructure by contributing to the advancement of the area of microgrid optimization.
The study of an Economic Integration of a Microgrid for the University of Management and Technology Sialkot
Authors: Awan Muhammad Mateen Afzal , Abbas Syed Manzar
Published: October 2024

The finest microgrid design has been proposed in this research to ensure a smooth energy supply for the University of Management and Technology (UMT) Lahore, Sialkot Iqbal campus, Pakistan at the cheapest price. The design methodology considered resource availability, environmental feasibility, economic feasibility, and renewable integration. The university can utilize the energy from the Sun, fossil fuel, and national grid. Integrating the available energy resources, data collection, and forecasting multiple parameters were simulated to design the optimal microgrid. The optimal design is selected based on the net present cost (NPC), renewable fraction (RF), operating cost (OC), repair and maintenance cost (O and MC), etc. Out of the 48 viable simulated designs, the optimal design has a PV system, generators, and the grid to fulfill energy demand at a net present cost of $116,987, with a renewable portion of 95%. In contrast, the worst simulated design depends on generators and battery backup, resulting in a $2.93 million NPC with a renewable segment of 24.3%.
AVALIAÇÃO DAS CONDUTAS PROFILÁTICAS NOS ATENDIMENTOS ANTIRRÁBICOS HUMANOS PÓS-EXPOSIÇÃO EM RIO VERDE – GO, ENTRE 2015 E 2019
Authors: Martins Andressa Vaz , Cassimiro Geovana Carolaine Ramos , Cruz Carolina de Alvarenga , Paula Eric Mateus Nascimento de , Sousa Daniel Bartoli de , Braga Ísis Assis , Gitti Clayton Bernardinelli , Nascif Júnior Iucif Abrão , Oliveira Stefan Vilges de , Meirelles-Bartoli Raphaella Barbosa
Published: October 2024

A raiva é uma zoonose, cujo agente etiológico é um vírus do gênero Lyssavirus, da família Rhabdoviridae, e se manifesta como uma encefalomielite aguda, quase sempre fatal. Como não há tratamento específico, o Ministério da Saúde recomenda que todo indivíduo exposto ao vírus da raiva receba a profilaxia pós-exposição, que se inicia com a notificação por meio da Ficha de Investigação do Atendimento Antirrábico Humano, e que, após anamnese completa, permite a indicação da profilaxia adequada. O objetivo deste trabalho foi levantar os tratamentos indicados nos acidentes envolvendo animais potencialmente transmissores da raiva, o cumprimento das profilaxias pelos pacientes, assim como avaliar a conduta profilática instituída, em Rio Verde, Goiás. Para tal, realizou-se levantamento de dados extraídos das fichas de notificação do Sistema de Informação de Agravos de Notificação, acessados e analisados em Microsoft Excel 2019®, entre 2015 e 2019. Obteve-se como tratamento mais recomendado a observação + vacina, em 59,79% dos atendimentos, seguida pela observação do animal agressor apenas, em 29,16% dos casos. A interrupção de tratamento ocorreu em 56,5% dos atendimentos realizados, sendo em 28,40% desses, por abandono. Durante o intervalo analisado, 31,56% das profilaxias indicadas foram incoerentes. O estudo permitiu o levantamento dos tratamentos indicados, seu cumprimento, além de indicar o alto índice de esquemas profiláticos inadequados, apontando para a necessidade de constante capacitação dos profissionais responsáveis pelo atendimento e ações de vigilância epidemiológica.
DO THIRD-PARTY FUNDS AND BANK RISKS AFFECT THE PROFITABILITY OF DIGITAL BANKS ?: INDONESIAN EVIDENCE
Authors: Parlindungan Salomon , Dewi Vera , Widyarini Maria , Soei Catharina , Candradiningrat Ica Rika
Published: October 2024

This study was conducted on five digital banks in Indonesia, examining the effects of third-party funds (TPF) and bank risks, including credit, market, and operational risks, on profitability. This research employs a quantitative-explanatory approach and uses 96 observational data from five Indonesian digital banks' websites using quarterly financial data from 2019-2023. This study presents novel empirical evidence that the CAR has a positive effect on digital banks' profitability (ROA), and operational risk (OCOI) has a negative effect on profitability (ROA). Using panel data regression, this study finds that TPF and market risks do not significantly affect profitability. The study underscores the crucial role of digital banks' operational and credit risks in profitability while also revealing that TPF and market risk are not among the main drivers of digital banks' profitability.
PSS Application on Business Process Improvement of Equipment Pool System in Mining Company
Authors: Firdaus Frans , Mulyono Nur Budi
Published: October 2024

This research identifies challenges in the management of heavy equipment in a mining company, particularly in the face of increasing operational costs. This research aims to explore and implement strategies that can enhance the efficiency and effectiveness of the equipment pool system. The objectives are to increase equipment utilization, improve inter-division collaboration, and propose potential cost-saving measures. The study pinpoints the weaknesses in the current equipment pool system, primarily triggered by sudden and unplanned requests, leading to suboptimal utilization and decision- making. By examining performance availability and utilization metrics for quantitative data and interviewing the respondents for qualitative data, the research highlights the DMAIC framework to produce alternative solutions and answer the research objectives. Each phase of the DMAIC framework is utilized to elaborate the business problem and solution through the utilization of Kepner-Tregoe Problem Analysis, Product-service System, and Business Process Mapping improvements. The results of the study highlight considerable opportunities for improving equipment utilization through enhanced coordination and sharing practices across different divisions. Key contributors to underutilization were identified, leading to the proposal of a centralized equipment pool system. The implications of implementing this system are significant for the company. The introduction of a more collaborative and cost-efficient approach to managing heavy equipment is anticipated to result in notable cost savings and heightened operational efficiency. Furthermore, the insights and framework developed through this study can serve as a valuable model for other large-scale mining operations encountering similar challenges.
Die Übertragung von Routineformeln in andere Kulturen
Authors: Lohkemper Alina
Published: October 2024

Der idiomatische Bereich einer Sprache ist für Fremdsprachenlernende oft schwer zu erfassen. Während sich viele ein- und zweisprachige Wörterbücher mit Sprichwörtern beschäftigen, wird den Konversationsroutinen wenig Aufmerksamkeit geschenkt, obwohl diese auf kommunikative Handlungen mit rituellem Charakter innerhalb einer Gesellschaft hinweisen (vgl. Coulmas 1981, 16). In diesem Aufsatz werden daher einige Routinen in ihrer Übersetzung aus dem Italienischen ins Deutsche in ausgewählten Wörterbüchern und Lehrbüchern untersucht, um zu prüfen, ob sie auf allen relevanten sprachlichen Ebenen kongruent sind. Dabei werden insbesondere die Unterschiede zwischen Form und Funktion hervorgehoben.
Contemporary problems of settlement in the ethnic plain villages of the northwestern regions of Azerbaijan (on the example of the Balakan administrative district)
Authors: Huseynova Bayimkhanim A.
Published: October 2024

The geographical position of the region, ethnic composition, acceleration of the process of polarization among rural settlements, and other factors increase the relevance of the research. The subject of the research is the study of rural settlement problems, and the object of the research is the villages and ethnic minorities of the Balakan district. The study aims to reveal the modern problems of the settlement of ethnic minorities and the formation of rural agglomerations, to study the causes of the emptying of some villages, and to prepare a rural development model to prevent the problems. To conduct research, the literature and statistical materials were analyzed, as well as cartographic, comparative analysis, SWOT, and modelling methods were used. Moreover, a field investigation was conducted in the research area. It was revealed that although a majority of the rural population settles in villages with a high demographic potential, villages with a weak demographic potential, due to their higher number, play a major role in the settlement system. Moreover, some villages form rural agglomerations, while some of them lose their population due to socioeconomic challenges. Due to the intense migration processes, some villages have turned into endangered villages (Mazimustu, Goyrujuluk), and even some villages are on the brink of extinction (Bayrambina, Mazimchay, Abjit). Studying the regulation of rural settlement in the region is of practical importance in terms of ensuring the equal development of the region, ensuring the security of the borders, and protecting ethnic minorities. However, there is still a need for serious research in this field.
Metropolization process in the rural settlement system of the Central Chernozem region of Russia
Authors: Chugunova Nadezhda V. , Lisetskii Fedor N. , Narozhnyaya Anastasiya G. , Polyakova Tatjana A. , Morkovskaya Darja N.
Published: October 2024

The Central Chernozem region of Russia has undergone significant changes in socio-demographic processes over the past half-century. The aim of this study was to establish the impact of metropolization on the demographic transformation of sparsely populated rural settlements for the Central Chernozem region and to develop a demographic forecast for 2030. The study’s goals were to (1) determine the scale of regional metropolises; (2) identify the impact of metropolization on the quantitative indicators of sparsely populated rural settlements; (3) establish trends in their transformation; and (4) compile a medium-term demographic forecast for the Central Chernozem region. The set objectives were achieved by integrating methods for spatial-temporal and comparative geographical analysis, statistical methods, and a combination of official statistics with sociological methods. Analysis of the level of urbanization of the regions in modern conditions (20th and 21st centuries) showed that, although this process was and remained below the national average, it did not prevent the formation of regional metropolises (Belgorod, Stary Oskol, Kursk, Voronezh, Lipetsk, Tambov) as an obvious outcome of urbanization processes. A regional pattern of degradation of the network of rural settlements, mainly the smallest and small in terms of population (1-25, 26-50 people), which make up over one third of all settlements in the Central Chernozem region of Russia, was determined. A stable long-term trend of growth in the number of abandoned villages and hamlets was established. Between the last two All-Russian population censuses (11 years), their number increased by 45%. The forecasting results obtained confirm the established patterns in the medium-term trend of “compression” of rural settlement around regional metropolis (with some exceptions). The medium-term demographic forecast showed that population concentration in metropolitan areas and further socio-demographic desertification in peripheral areas will continue with growing territorial differentiation. The obtained results of the study of the transformation of settlement systems of the Central Chernozem region as a result of the metropolization of regional centers can help government institutions in strategic planning of territorial development.