bluuebunny/crossref_metadata_2025 huggingface dataset:
Silver-Doped Zirconia Nanoparticles as Possible Bactericide in Water Filters
Authors: Rodrigues Ermerson Ney Leite , Miranda Jr. Edson Jansen Pedrosa , Oliveira M.M.
Published: June 2014

The objectives of this study were to produce ZrO2-based nanoparticles doped with silver, using the polymeric precursor method (Pechini), and to verify their bactericidal activity againstEscherichiacoliandStaphylococcusaureus. Zirconium and silver oxides were chosen due to their bactericidal activity. The oxides were characterized by X-ray diffraction and field emission gun-scanning electron microscopy. The support for the oxides was a porous surface used in gravity filters. The method was not effective against the bacteriumEscherichiacoliin the sample subjected to UV light for 45 min, since it did not eliminate the bacterium, and did not inhibit colony growth and formation. However, the bactericidal activity test proved effective againstStaphylococcusaureus, eliminating the bacterium when the sample was subjected to UV light for 45 min, thus preventing colony growth and formation.
Compaction of ZrO2(Y2O3) Powders with Different Particle Sizes and Effects on the Sintering
Authors: da Silva Camila Aparecida Araújo , de Assis Luiz Cláudio Lemos , Magnago Roberto de Oliveira , Palmeira Alexandre Alvarenga , Villanova Gabriel Rocha Lellis , dos Santos Claudinei
Published: June 2014

In this work, compacting powders of different ZrO2(Y2O3) are investigated relating the particle size, compaction pressure, and use of binders. Powders of ZrO2stabilized with 3mol % Y2O3with an average particle size of 0.15 to 0.7μm presence of both bonding and 0.15μm without addition of binder, were uniaxially compacted with pressures of 30 to 115MPa. Green density between 40% and 50% were obtained. The results indicate that powders sized less densification above 1400°C, while the larger sizes only after reaching full densification above 1500°C. Crystallographic characterization indicates that the powders have a percentage of monoclinic phases in the range of 15% to 26%, but only after sintering tetragonal phase is identified.
Experimental Planning of Mixtures to Obtain Geopolymer
Authors: Pereira Carlos Eduardo , Alves José Jailson Nicácio , Menezes Romualdo Rodrigues , Santos José Otávio Peroba Nascimento , de Sousa Bianca Viana
Published: June 2014

This work had the aim to optimize the synthesis process of a geopolymer using experimental planning of mixtures. The geopolymer was prepared with different proportions of bauxite mud (R), rice husk ash (C) and metakaolin (M). The aluminosilicatealkaline activation was made with sodium hydroxide (NaOH) solution of 12 mol/L. Afterwards, the obtained material was submitted through a thermal treatment for 6 hours in an oven followed by a cure time of 28 days at room temperature. The final material was characterized through combinations of different techniques such as Scanning Electron Microscopy (SEM) and X-Ray Diffraction. Through carefully analysis of the flexural strength results, it was possible to conclude that the geopolymeric material (R6C2M) had a greater resistance in the seventh cure day at 0.6 MPa, however, it also can be said that the other samples presented an increase in the resistance over the 28 days of cure time.
Use Residue of Bagasse Sugar Canein Synthesis of Molecular Sieve MCM-41
Authors: Lima L.A. , Menezes Virgínia Maria Ramalho , Freire Rodrigues Meiry Glaúcia
Published: June 2014

A mesoporous molecular sieve MCM-41 dimensional hexagonal arrangement has a diameter of 2-10 nm, thermal stability, high pore volume and high surface area. In the synthesis of MCM-41 is used as the CTMABr directing agent and tetraethyl orthosilicate (TEOS) as silica source. Several studies have been developed using the residue of bagasse sugar cane, due to the high percentage of silica in its composition, making it a promising source for materials synthesis, favoring the use of this product impactful to the environment. This paper aims at the synthesis and characterization of MCM-41 with molar composition: 1.0 CTMABr: 4.0 SiO2: 1 Na2O: 200 H2O using waste. The materials were characterized by the techniques of X-ray Diffraction (XRD), chemical analysis by X-ray spectrometry, energy dispersive (EDX) spectroscopy and in the infrared (IR). ). By XRD and IR verified the formation of mesoporous molecular sieve MCM-41. The XRD of the as-synthesized samples MCM-41 displayed the characteristic (1 0 0) reflection of typical MCM-41, with EDX was observed high silica content in the residue of bagasse sugar cane.
On the role of Susanna in Susanna: A Greimassian contribution
Authors: Kanonge Dickh M. , Jordaan Pierre J.
Published: June 2014

This article addresses the highly disputed distribution of roles in the story of Susanna. Susanna consists of a number of actors of whom only a few such as Susanna, the two elders, the Jewish people and Daniel are directly related to the central action of the story. With regard to roles of these actors in the story however, a question arises: ‘who is the subject of the story of Susanna?’ Most scholars question the attribution of the role of subject to Susanna.Their contention however, has not yet been sustained by convincing evidence stemming from the use of a suitable method.  This study attempts to fill this gap by using the Greimassian approach to narratives, as refined by Everaert-Desmedt. The approach comprises three levels of analysis: the figurative, the narrative and the thematic. The contribution focuses only on the narrative level of analysis, particularly on the actantial model because the main role of this structure is to reveal different functions of actors called here actants. It is the contention here that following the actantial model of the Greimassian approach of analysis Susanna emerges as the subject of the aim concern of the story.
Aspekte van ’n omkeerproses
Authors: Van Helden Sophia
Published: June 2014

In hierdie artikel word gefokus op aspekte wat deel uitmaak van ’n omkeerproses. Sodanige proses behoort oorweeg te word waar krimpende gemeentes in ’n doodloopstraat verkeer. Alhoewel die kompleksiteit van so ’n proses duidelik na vore kom, is ’n omkeerproses tog moontlik. Die Skrifbeginsels wat so ’n proses moontlik maak, behoort binne elke gemeentelike konteks uniek ontdek en toegepas te word. Die diepgrondige selfleerproses en die voordele wat ’n waarderende taalaanpak (‘Waarderende Ondersoek’) in die proses het, lei tot die besef dat nie net die inhoud nie, maar ook die manier waarop dit gedoen word van ’n omkeer behoort te getuig. Die talle verweefde aspekte waaraan aandag gegee word, kan rigtinggewend wees vir diegene wat erns maak met die moontlikheid om groeiende en gesonde kerkpraktyke daar te stel.This article focuses on aspects regarding a turnaround process. Such a process ought to be considered where declining congregations face a dead end. Although the complexity of a turnaround is clear, such a process is still possible. The scriptural principles regarding the possibility of such a process ought to be discovered and contextually applied by each unique congregation. A deep whole-hearted self-learning process, as well as the positives of an appreciative language approach (Appreciative Inquiry), conclude that not only the contents of the turnaround, but also the manner in which it is done, ought to speak of a turnaround. The many intertwined aspects discussed in this article can direct those who are serious about the possibility of establishing growing and healthy church practices.
Steroids in critically ill-patients with septic shock and acute respiratory distress syndrome: A limited review of current knowledge
Authors: De Regt Jouke
Published: June 2014

The role of corticosteroids in critically ill patients has always been discussed by researchers and clinicians dedicated in the related field. Despite several decades of clinical studies exploring their role in both sepsis and treatment of acute respiratory distress syndrome (ARDS), their use remains controversial. This short review highlights current knowledge and opinions.
The Relationship between Return on Investment and Quality of Study Methodology in Workplace Health Promotion Programs
Authors: Baxter Siyan , Sanderson Kristy , Venn Alison J. , Blizzard C. Leigh , Palmer Andrew J.
Published: June 2014

Objective.

To determine the relationship between return on investment (ROI) and quality of study methodology in workplace health promotion programs.

Data Source.

Data were obtained through a systematic literature search of National Health Service Economic Evaluation Database (NHS EED), Database of Abstracts of Reviews of Effects (DARE), Health Technology Database (HTA), Cost Effectiveness Analysis (CEA) Registry, EconLit, PubMed, Embase, Wiley, and Scopus.

Study Inclusion and Exclusion Criteria.

Included were articles written in English or German reporting cost(s) and benefit(s) and single or multicomponent health promotion programs on working adults. Return-to-work and workplace injury prevention studies were excluded.

Data Extraction.

Methodological quality was graded using British Medical Journal Economic Evaluation Working Party checklist. Economic outcomes were presented as ROI.

Data Synthesis.

ROI was calculated as ROI = (benefits − costs of program)/costs of program. Results were weighted by study size and combined using meta-analysis techniques. Sensitivity analysis was performed using two additional methodological quality checklists. The influences of quality score and important study characteristics on ROI were explored.

Results.

Fifty-one studies (61 intervention arms) published between 1984 and 2012 included 261,901 participants and 122,242 controls from nine industry types across 12 countries. Methodological quality scores were highly correlated between checklists (r = .84–.93). Methodological quality improved over time. Overall weighted ROI [mean ± standard deviation (confidence interval)] was 1.38 ± 1.97 (1.38–1.39), which indicated a 138% return on investment. When accounting for methodological quality, an inverse relationship to ROI was found. High-quality studies (n= 18) had a smaller mean ROI, 0.26 ± 1.74 (.23–.30), compared to moderate (n= 16) 0.90 ± 1.25 (.90–.91) and low-quality (n= 27) 2.32 ± 2.14 (2.30–2.33) studies. Randomized control trials (RCTs) (n= 12) exhibited negative ROI, −0.22 ± 2.41(–.27 to –.16). Financial returns become increasingly positive across quasi-experimental nonexperimental, and modeled studies: 1.12 ± 2.16 (1.11–1.14), 1.61 ± 0.91 (1.56–1.65), and 2.05 ± 0.88 (2.04–2.06), respectively.

Conclusion.

Overall, mean weighted ROI in workplace health promotion demonstrated a positive ROI. Higher methodological quality studies provided evidence of smaller financial returns. Methodological quality and study design are important determinants.
Evaluating the accuracy of NOx emission fluxes over East Asia by comparison between CMAQ-simulated and OMI-retrieved NO2 columns with the application of averaging kernels from the KNMI algorithm
Authors: Han K. M. , Lee S. , Chang I. S. , Song C. H.
Published: June 2014

Abstract. To evaluate the accuracy of bottom-up NOx emissions in East Asia, CMAQ-calculated NO2 columns were compared with OMI-retrieved NO2 columns. For a direct comparison between the two NO2 columns, the averaging kernels (AKs) retrieved from the Royal Netherlands Meteorological Institute (KNMI) algorithm were applied to the CMAQ model simulations. When the two NO2 columns before and after the applications of AKs were compared over East Asia, it was found that, for example, the normalized mean errors (NMEs) between the CMAQ-estimated and OMI-retrieved NO2 columns were reduced significantly, from ∼103% to ∼46%, from ∼112% to ∼ 45%, and from ∼135% to ∼40% during spring, fall, and winter, respectively. Also, the two tropospheric NO2 columns were better correlated spatially in East Asia (R = 0.71–0.94) after the application of the AKs. From this study, it was found that the NOx emissions used were, on annual average, ∼28% underestimated in East Asia, although some overestimates were also found, partly over southern Central East China, the Sichuan Basin, and South Korea regions during the winter. However, these results can also be influenced by several uncertainty factors in the CMAQ model simulations, such as monthly variation and the strength of the NOx emissions. Thus, we also applied different monthly variation and different strengths of the NOx emissions to the CMAQ model simulations over East Asia. The results showed strong impacts on the tropospheric NO2 columns in East Asia, indicating that these two factors are also important. Further sensitivity analysis was conducted with reaction probabilities of N2O5 onto atmospheric aerosols. Those results are also discussed in detail in this manuscript. Although several uncertainty factors are discussed, it was concluded that the consideration of the AKs is the single most important factor in investigating the accuracy of bottom-up NOx emissions generally being used in CTM simulations.
Water vapor retrieval from OMI visible spectra
Authors: Wang H. , Liu X. , Chance K. , González Abad G. , Chan Miller C.
Published: June 2014

Abstract. There are distinct spectral features of water vapor in the wavelength range covered by the Ozone Monitoring Instrument (OMI) visible channel. Although these features are much weaker than those at longer wavelengths, they can be exploited to retrieve useful information about water vapor. They have an advantage in that their small optical depth leads to fairly simple interpretation as measurements of the total water vapor column density. We have used the Smithsonian Astrophysical Observatory (SAO) OMI operational retrieval algorithm to derive the slant column density (SCD) of water vapor using the 430–480 nm spectral region after extensive optimization. We convert from SCD to vertical column density (VCD) using the air mass factor (AMF), which is calculated using look-up tables of scattering weights and assimilated water vapor profiles. Our Level 2 product includes not only water vapor VCD but also the associated scattering weights and AMF. In the tropics, our standard water vapor product has a median SCD of 1.3 × 1023 molecules cm−2 and a median relative uncertainty of about 11%, about a factor of 2 better than that from a similar OMI algorithm that uses a narrower retrieval window. The corresponding median VCD is about 1.2 × 1023 molecules cm−2. We have examined the sensitivities of SCD and AMF to various parameters and compared our results with those from the GlobVapour product, the Moderate Resolution Imaging Spectroradiometer (MODIS) and the Aerosol Robotic NETwork (AERONET).
Projected impacts of climate change and ocean acidification on the global biogeography of planktonic foraminifera
Authors: Roy T. , Lombard F. , Bopp L. , Gehlen M.
Published: June 2014

Abstract. Planktonic foraminifera are a major contributor to the deep carbonate-flux and the planktonic biomass of the global ocean. Their microfossil deposits form one of the richest databases for reconstructing paleoenvironments, particularly through changes in their taxonomic and shell composition. Using an empirically-based foraminifer model that incorporates three known major physiological drivers of foraminifer biogeography – temperature, food and light – we investigate (i) the global redistribution of planktonic foraminifera under anthropogenic climate change, and (ii) the alteration of the carbonate chemistry of foraminifer habitat with ocean acidification. The present-day and future (2090–2100) 3-D distributions of foraminifera are simulated using temperature, plankton biomass, and light from an Earth system model forced with historical and a future (IPCC A2) high CO2 emission scenario. The broadscale patterns of present day foraminifer biogeography are well reproduced. Foraminifer abundance and diversity are projected to decrease in the tropics and subpolar regions and increase in the subtropics and around the poles. In the tropics, the geographical shifts are driven by temperature, while the vertical shifts are driven by both temperature and food availability. In the high-latitudes, vertical shifts are driven by food availability, while geographical shifts are driven by both food availability and temperature. Changes in the marine carbon cycle would be expected in response to (i) the large-scale rearrangements in foraminifer abundance, and (ii) the reduction of the carbonate concentration in the habitat range of planktonic foraminifers: from 10–30 μmol kg−1 in the polar/subpolar regions to 30–70 μmol kg−1 in the subtropical/tropical regions. High-latitude species are most vulnerable to anthropogenic change: their abundance and available habitat decrease and up to 10% of their habitat drops below the calcite saturation horizon.
Recurrent cerebral ischaemia in a pregnant woman with patent foramen ovale II° and thrombophilia
Authors: Hendelmeier M. , von Bardeleben R. , Gröschel K. , Schinzel H. , Hecking C.
Published: June 2014

This case report concerns a pregnant multipara (age: 27 years) in the 16th gestational week. She developed a sudden onset of paraesthesia in her left lower arm although injecting dalteparin 5000 IU once daily subcutaneously (s. c.) due to a heterozygous factor V Leiden mutation and a prior miscarriage in the first pregnancy and preeclampsia in her third pregnancy. After the miscarriage she delivered two healthy children under prophylactic anticoagulation with low molecular weight heparin (LMWH). Now via magnetic resonance imaging (MRI) she was diagnosed as having multiple cerebral ischaemic lesions. Further workup revealed the presence of a patent foramen ovale (PFO) II° but no venous thrombosis in her legs. She was then treated with dalte parin 5000 IU twice daily by subcutaneous injections.

At 19th gestational week she developed paraesthesia in her left lower arm again. The MRI showed a cortical lesion in the territory of the right median cerebral artery. The anticoagulation dose was increased stepwise under surveillance of the anti-FXa-level 3–4 h after subcutaneous injections aiming to achieve the supratherapeutic range of 1.2–1.5 IU/ml anti-Xa-units. No more neurological symptoms appeared under this antithrombotic therapy. The patient delivered by induction of labor at the 38th gestational week.
Evaluación de la competencia profesional en personas con discapacidad intelectual. Una propuesta de adaptación de la metodología e instrumentos INCUAL para la igualdad de oportunidades
Authors: Docampo Núñez Gonzalo , Morán de Castro M. Carmen
Published: June 2014

La incorporación efectiva al empleo de las personas con discapacidad intelectual requiere atender especialmente a los procesos de transición a la vida adulta, con la formación y la orientación laboral como estrategias relevantes. La posibilidad de demostrar lo que son capaces de hacer mediante pruebas adecuadas para ello, además de avanzar en la igualdad de oportunidades, representaría un proceso de habilitación para la inserción laboral. Desde esta perspectiva, tomando como referencia las orientaciones del Instituto Nacional de las Cualificaciones (INCUAL), se ha procedido a adaptar y aplicar los instrumentos de evaluación de competencias profesionales para determinar la capacidad de desempeño del perfil profesional de operaciones básicas de montaje del alumnado con discapacidad intelectual de un centro ocupacional. Los resultados confirman la validez de la adaptación, la ampliación de posibilidades de inserción laboral en la Comarca do Sar (Galicia), así como el efecto retroalimentador en los itinerarios formativos y de orientación laboral del centro.
Los recursos educativos que los profesores de Secundaria estiman necesarios para desarrollar procesos educativos inclusivos
Authors: Díaz Gandasegui Vicente
Published: June 2014

El presente artículo se ha elaborado a partir de una investigación llevada a cabo por profesores del departamento de Análisis Social de la Universidad Carlos III de Madrid y financiada por la Fundación ONCE. En ella se han utilizado encuestas y entrevistas en profundidad para conocer las necesidades y carencias del profesorado de secundaria para desarrollar procesos educativos inclusivos. La información recogida refleja que tanto los profesores como los centros educativos no disponen, de manera homogénea, de los recursos necesarios para que todos los estudiantes puedan educarse de manera conjunta. Disponer de políticas y proyectos educativos inclusivos, un centro adaptado arquitectónicamente, materiales adaptados a cada discapacidad, apoyos a la docencia y una disminución de la ratio profesor/alumno son recursos que facilitan la inclusión de los alumnos con discapacidad. No obstante, la ausencia de estos recursos genera exclusión y crea barreras para desarrollar un proceso inclusivo educativo.
La Accesibilidad Universal y el Diseño para todos desde la perspectiva de género
Authors: de la Fuente Robles Yolanda Mª , Hernández-Galán Jesús
Published: June 2014

Ser mujer con discapacidad hoy, supone un reto añadido si se aplica a los diferentes modelos de mujer que conviven en la realidad social. Aunque las políticas destinadas a este sector de mujeres deban ser específicas, una necesidad vital une a las mujeres con y sin discapacidad: desarrollarse como mujeres completas en un mundo en demasiada ocasiones hostil, donde todo tipo de servicios relacionados con las tecnologías de la información y de la comunicación (TIC), los entornos físicos, etc., se convierte en nada cuando se obvia la premisa principal, diseñar pensando en todos y en todas. Por ello presentamos esta reflexión sobre la situación actual y las actuaciones que son necesarias para posicionar a las mujeres con discapacidad en igualdad con el resto de la ciudadanía.
Los signos manuales como sistema de comunicación alternativa y aumentativa. Artículo de revisión
Authors: Vega Llobera Fàtima , Gràcia Garcia Marta
Published: June 2014

Hay una larga tradición científica sobre el uso de los signos manuales de manera simultánea a la lengua oral para promover el desarrollo de la comunicación y el lenguaje en niños con o sin discapacidad. Este artículo tiene como objetivo revisar y analizar trabajos de intervención centrados en el uso de signos manuales como sistema de comunicación aumentativa (AAC) en participantes oyentes. Se han utilizado diversos criterios para delimitar la búsqueda, selección, codificación y síntesis de los 50 artículos científicos originales que finalmente han formado parte de la revisión. Se han incluido estudios publicados desde 1970 hasta la actualidad, nacionales e internacionales, en lengua inglesa y española, utilizando búsquedas mediante palabras clave en bases de datos bibliográficas, en motores de búsqueda (Google Académico) y en citas bibliográficas. La información obtenida mediante los artículos científicos seleccionados ha puesto de manifiesto que, a pesar de la diversidad en cuanto a resultados, el uso de los signos como sistema de comunicación aumentativo es efectivo para mejorar el desarrollo del lenguaje, en el aspecto receptivo y expresivo.
Aspectos éticos en la participación de personas con diversidad funcional en proyectos de investigación tecnológica
Authors: Sainz de Salces Fausto Javier , Bustamante Donas Javier
Published: June 2014

La involucración de personas con diversidad funcional en proyectos de investigación tecnológica tiene ciertas peculiaridades en el plano ético que deben ser consideradas por todos aquellos implicados en el proceso. El estudio de estas consideraciones desde un punto de vista teórico sustentado por la praxis nos lleva a presentar una aproximación a los problemas de orden práctico que plantean estas actividades. Ante la carencia de protocolos establecidos, presentamos en este artículo un marco integrado de evaluación ética que considere como parámetros principales a tener en cuenta el trato adecuado, el respeto a la privacidad, el estímulo a la expresión de opiniones, la gestión de las relaciones personales establecidas y la decepción por parte de los sujetos participantes
La Atención Temprana Infantil y su praxis
Authors: Belda Oriola Juan Carlos
Published: June 2014

Belda Oria, J.C. (2014): “La Atención Temprana infantil y su praxis”. Revista Española de Discapacidad, 2 (1): 195-201.
Asociaciones de padres y seguimiento multidisciplinar de la gran prematuridad
Authors: Gómez Esteban Concepción
Published: June 2014

Gómez Esteban, C. (2014): “Asociaciones de padres y seguimiento multidisciplinar de la gran prematuridad”. Revista Española de Discapacidad, 2 (1): 203-213.
Inversión necesaria, urgente y asequible en salud mental. Propuestas de FEAFES
Authors: Sánchez Monge José Mª
Published: June 2014

Sánchez Monge, J.M. (2014): “Inversión necesaria, urgente y asequible en salud mental. Propuestas de FEAFES”. Revista Española de Discapacidad, 2 (1): 215-221.
Propuesta de intervención en el ámbito del ocio y tiempo libre de usuarios/as de COCEMFE Cáceres
Authors: Rebolledo Gutiérrez Juan Carlos , Rohlfs Domínguez Paloma
Published: June 2014

Rebolledo Gutiérrez, J.C. y Rohlfs Domínguez, P. (2014): “Propuesta de intervención en el ámbito del ocio y tiempo libre de usuarios/as de COCEMFE Cáceres”. Revista Española de Discapacidad, 2 (1): 223-231.
Human-robot Team Coordination That Considers Human Fatigue
Authors: Zhang Kai , Li Xiaobo
Published: June 2014

Many applications for robots require them to work alongside people as capable members of human-robot teams and to collaborate in order to perform tasks and achieve common goals. These tasks can induce strain on the human due to time constraints. Additionally, humans can become highly stressed due to fatigue, resulting in decreased efficiency. The contribution of this paper is in the introduction of a human fatigue model and the application of this model to a mixed team coordination framework in order to predict team performance given the constraints of human fatigue. The human fatigue model - namely a FAtigue Prediction (FAP) model - is used to conduct numerical simulations that predict mixed team performances. Specifically, extensive simulations are performed to determine how human fatigue influences the choice of the number of agents for a given number of tasks. The novel mixed team coordination framework is a Stochastic Clustering Auction (SCA), which is based on a modification of the Swendsen-Wang method, called SW2SCA. It enables complex and efficient movement between clusters by connecting tasks that appear to be synergistic and then stochastically reassigning these connected tasks. In SW2SCA, the auctioneer makes stochastic movements with homogeneous or heterogeneous agents. The final discussion outlines a systematic procedure to predict the performance of human-robot systems with the FAP model in SCA.
Antithrombin Levels Are Unaffected by Warfarin Use
Authors: Sanfelippo Michael J. , Engel Jessica M. , Onitilo Adedayo A.
Published: June 2014

Context.—The results of studies among patients with antithrombin deficiency have suggested that the use of warfarin will increase the level of antithrombin.

Objective.—To reevaluate the effect of warfarin on antithrombin levels using an automated amidolytic method in current use.

Design.—Antithrombin levels were measured in patients who were receiving warfarin for atrial fibrillation and were compared with antithrombin levels in preoperative patients who had not received warfarin.

Results.—Patients receiving warfarin had a mean antithrombin level of 100.40% (range, 81%–153%). Patients not receiving warfarin had a mean antithrombin level of 99.97% (range, 79%–120%). The Student t test was not significant for a difference between the mean antithrombin levels of the 2 populations.

Conclusions.—The use of warfarin does not increase the level of antithrombin in patients receiving the drug.
De Novo CD3 Negative Hepatosplenic T-cell Lymphoma: Diagnostic Challenges and Pitfalls
Authors: Kapur Lucy Harn , Khaled Yasser , Solh Melhem , Ward David , Chang Chung-Che
Published: June 2014

Hepatosplenic T-cell lymphoma is a rare and aggressive peripheral T-cell malignancy that is distinctively characterized by sinusoidal infiltration of mature medium-sized T lymphocytes in the spleen and liver. The neoplastic cells are classically surface CD3+, CD2+, CD5−, CD4−, and CD8+/− and manifest variable expression of markers associated with natural killer (NK) cells such as CD16 and CD56. In this article, we report the first case to date of a newly diagnosed de novo surface CD3− hepatosplenic T-cell lymphoma with circulating blastlike neoplastic cells expressing NK-cell–associated markers. The lack of surface CD3 expression, together with the expression of NK-cell–associated markers and the leukemic presentation, leads to significant diagnostic challenges in differentiating this CD3− hepatosplenic T-cell lymphoma from NK-cell neoplasms, in particular aggressive NK-cell leukemia. The related literature is reviewed, and the approaches for adequate diagnosis of this novel situation are described.
A Newly Developed Uroplakin II Antibody With Increased Sensitivity in Urothelial Carcinoma of the Bladder
Authors: Hoang Laura L. , Tacha David E. , Qi Weimin , Yu Charlie , Bremer Ryan E. , Chu Joseph , Haas Thomas S. , Cheng Liang
Published: June 2014

Context.—Uroplakin II is a 15-kDa protein component of the urothelial plaques that enhance the permeability barrier and strength of the urothelium. Studies have shown uroplakin II messenger RNA to be expressed in bladder cancer tissues and peripheral blood of patients with urothelial carcinoma. Little is known about the protein expression of uroplakin II in urothelial carcinoma, possibly because of the absence of a commercially available uroplakin II antibody. Pathologists have used the uroplakin III antibody (AU1) to identify tumors of urothelial origin; however, the use of AU1 is limited because of its poor sensitivity.

Objectives.—To evaluate a newly developed mouse monoclonal uroplakin II antibody (BC21) in urothelial carcinoma and to compare it with previously developed mouse monoclonal uroplakin III (BC17 and AU1).

Design.—Uroplakin II and III antibodies were optimized for staining using a horseradish peroxidase-polymer detection system and were visualized with 3,3′-diaminobenzidine.

Results.—BC21, BC17, and AU1 demonstrated sensitivities in urothelial carcinoma of the bladder of 79% (44 of 56), 55% (31 of 56) (P = .002), and 34% (19 of 56) (P < .001), respectively. Subsequently, the increased staining sensitivity and intensity of BC21, compared with BC17, was validated in a larger study (134 of 174; 77% and 94 of 174; 54%, respectively) (P < .001). BC21 was found to be highly specific when evaluated in various normal and neoplastic tissues, including prostatic and renal carcinomas.

Conclusions.—The mouse monoclonal uroplakin II antibody (BC21) demonstrated superior sensitivity and specificity in urothelial carcinoma, compared with uroplakin III (BC17 and AU1), suggesting its advantages in the differential diagnosis of urothelial carcinoma and in the detection of tumors of unknown origin.
Utility of Quantitative Flow Cytometry Immunophenotypic Analysis of CD5 Expression in Small B-Cell Neoplasms
Authors: Challagundla Pramoda , Jorgensen Jeffrey L. , Kanagal-Shamanna Rashmi , Gurevich Inga , Pierson Diane M. , Ferrajoli Alessandra , Reyes Steven R. , Medeiros L. Jeffrey , Miranda Roberto N.
Published: June 2014

Context.—The value of assessing CD5 expression in the differential diagnosis of small B-cell neoplasms is well established. Assessment is usually done qualitatively.

Objectives.—To assess CD5 expression levels by quantitative flow cytometry immunophenotyping and to determine possible differences among various small B-cell neoplasms.

Design.—We performed 4-color flow cytometry analysis on specimens of peripheral blood and bone marrow aspirate and quantified CD5 expression in various small B-cell lymphomas and leukemias. We also assessed CD5 levels in peripheral blood samples of healthy blood donors.

Results.—Cases of chronic lymphocytic leukemia and mantle cell lymphoma had higher levels of CD5 compared with control B cells (P < .001). Cases of marginal zone lymphoma and hairy cell leukemia had CD5 levels similar to control B cells (P = .35 and P = .14, respectively), whereas cases of follicular lymphoma and lymphoplasmacytic lymphoma had significantly lower CD5 levels than control B cells (P < .001 and P = .04, respectively). In B-cell neoplasms, a high level of CD5 expression was correlated with a homogeneous pattern of positive events, whereas lower CD5 levels were correlated with heterogeneous patterns of positive events.

Conclusions.—Using flow cytometric immunophenotypic analysis to quantify CD5 levels can aid in diagnosis. CD5 expression levels are higher in patients with chronic lymphocytic leukemia and mantle cell lymphoma, and expression is observed in a homogeneous pattern, as compared with other B-cell neoplasms that are either negative for CD5 or express CD5 at lower levels with a heterogeneous pattern. However, there is some overlap in CD5 expression levels between a subset of atypical chronic lymphocytic leukemia and marginal zone lymphoma cases.
Optimizing Outpatient Phlebotomy Staffing: Tools to Assess Staffing Needs and Monitor Effectiveness
Authors: Mijailovic Aleksandar S. , Tanasijevic Milenko J. , Goonan Ellen M. , Le Rachel D. , Baum Jonathan M. , Melanson Stacy E.F.
Published: June 2014

Context.—Short patient wait times are critical for patient satisfaction with outpatient phlebotomy services. Although increasing phlebotomy staffing is a direct way to improve wait times, it may not be feasible or appropriate in many settings, particularly in the context of current economic pressures in health care.

Objective.—To effect sustainable reductions in patient wait times, we created a simple, data-driven tool to systematically optimize staffing across our 14 phlebotomy sites with varying patient populations, scope of service, capacity, and process workflows.

Design.—We used staffing levels and patient venipuncture volumes to derive the estimated capacity, a parameter that helps predict the number of patients a location can accommodate per unit of time. We then used this parameter to determine whether a particular phlebotomy site was overstaffed, adequately staffed, or understaffed. Patient wait-time and satisfaction data were collected to assess the efficacy and accuracy of the staffing tool after implementing the staffing changes.

Results.—In this article, we present the applications of our approach in 1 overstaffed and 2 understaffed phlebotomy sites. After staffing changes at previously understaffed sites, the percentage of patients waiting less than 10 minutes ranged from 88% to 100%. At our previously overstaffed site, we maintained our goal of 90% of patients waiting less than 10 minutes despite staffing reductions. All staffing changes were made using existing resources.

Conclusions.—Used in conjunction with patient wait-time and satisfaction data, our outpatient phlebotomy staffing tool is an accurate and flexible way to assess capacity and to improve patient wait times.
Reliability of Point-of-Care Capillary Blood Glucose Measurements in the Critical Value Range
Authors: Schifman Ron B. , Nguyen Tan T. , Page Susan T.
Published: June 2014

Context.—Point-of-care glucose (POCG) testing on capillary blood specimens is central to maintaining glycemic control in patients with diabetes. Although there are known performance issues with POCG methods, especially for maintaining tight glucose control, there is little information about the accuracy of results in the critical ranges that may involve life-threatening conditions.

Objectives.—To evaluate the reliability of POCG measurements in critical, high (>600 mg/dL) and low (<40 mg/dL) ranges.

Design.—One-year retrospective analysis of POCG (ACCU-CHEK glucose meter, Roche Diagnostics Corporation, Indianapolis, Indiana) results for routine patient care were obtained. The frequency and accuracy of repeat testing after critical POCG results was analyzed. A convenience sample of noncritical capillary POCG measurements retested on venous blood specimens by another point-of-care device (RAPIDPoint 405 analyzer, Siemens Medical Solutions USA, Malvern, Pennsylvania) was also evaluated.

Results.—Critical values were observed in 2.4 per 1000 POCG tests (256 of 105,928; 0.24%), with the highest rate (76 of 2289; 3.32%) from the emergency department. Twice as many critical high values as critical low values were seen. Nearly 80% of critical POCG tests (204 of 256) were repeated within 10 minutes. Of these 204 repeat measurements, 112 (54.9%) met accuracy criteria (±15 mg/dL of low and ±20% of high initial values). Accuracy was significantly higher when retesting was performed on the same meter or by the same operator (P ≤ .05). Comparison of capillary and venous POCG testing of noncritical results showed no significant difference (P = .95), with 89.8% (125 of 139) meeting accuracy criteria.

Conclusions.—POCG measurements in the critical range are frequently erroneous, which is likely caused by preanalytic factors associated with sampling capillary blood. POCG testing practices should include retesting to confirm critical results.
Undergraduates’ Use of Social Media as Information Sources
Authors: Kim Kyung-Sun , Sin Sei-Ching Joanna , Yoo-Lee Eun Young
Published: June 2014

Social media have become increasingly popular among different user groups. Although used for social purposes, some social media platforms (such as Wikipedia) have been emerging as important information sources. Focusing on undergraduate students, a survey was conducted to investigate the following: (1) which social media platforms are used as information sources; (2) what are the main reasons for using these social media platforms for information seeking; and (3) what kinds of actions are taken to evaluate the quality of the information gained from such sources. The study provides a snapshot of current trends in terms of the use of social media as information sources. It also sheds lights on the actions that the undergraduate students took to evaluate information from social media, including social networking and video sharing sites that have rarely been studied previously. Based on the findings, suggestions are made for information literacy programs and roles of librarians and educators.
Dealing with Data: Science Librarians’ Participation in Data Management at Association of Research Libraries Institutions
Authors: Antell Karen , Foote Jody Bales , Turner Jaymie , Shults Brian
Published: June 2014

As long as empirical research has existed, researchers have been doing “data management” in one form or another. However, funding agency mandates for doing formal data management are relatively recent, and academic libraries’ involvement has been concentrated mainly in the last few years. The National Science Foundation implemented a new mandate in January 2011, requiring researchers to include a data management plan with their proposals for funding. This has prompted many academic libraries to work more actively than before in data management, and science librarians in particular are uniquely poised to step into new roles to meet researchers’ data management needs. This study, a survey of science librarians at institutions affiliated with the Association of Research Libraries, investigates science librarians’ awareness of and involvement in institutional repositories, data repositories, and data management support services at their institutions. The study also explores the roles and responsibilities, both new and traditional, that science librarians have assumed related to data management, and the skills that science librarians believe are necessary to meet the demands of data management work. The results reveal themes of both uncertainty and optimism—uncertainty about the roles of librarians, libraries, and other campus entities; uncertainty about the skills that will be required; but also optimism about applying “traditional” librarian skills to this emerging field of academic librarianship.
Les manifestes de Georg Baselitz, 1961-1994
Authors: Ziane Audrey
Published: June 2014

L’artiste Georg Baselitz ne « renverse » pas uniquement ses tableaux ; il réinvente, dans ses huit manifestes publiés entre 1961 et 1994, l’écriture manifestaire, liant et déliant volontairement le texte aux oeuvres picturales. Baselitz renoue ainsi avec la vision parnassienne de « l’art pour l’art », ne vit que dans son créatorium intérieur, où plane l’ombre d’Antonin Artaud, invente sous nos yeux son propre mythe. Comme Yves Klein et comme Orlan, Baselitz lira ensuite ses manifestes lors de conférences, tel un artiste-prédicateur. Si ses manifestes se sont délestés de leurs revendications tapageuses, ils gardent le goût de la subversion, créant un discours dans lequel se confrontent la création d’une mythologie personnelle et l’écrit-confession, qui amène l’artiste à exposer son intimité.
Le manifeste récupéré
Authors: Dubois Sophie
Published: June 2014

Reconnu comme une prise de position ponctuelle, le manifeste semble voué à une existence éphémère : une fois séparé de son époque, il perd de sa pertinence et de son efficacité. Aussi, lorsqu’une oeuvre commeRefus globalau Québec survit à l’épreuve du temps et acquiert le statut de « classique », son parcours mérite-t-il d’être interrogé. Il s’agit ici de poser la question de la survie du genre à partir de trois mécanismes — la réduction, la réutilisation et le recyclage — qui permettent au manifeste de s’inscrire dans l’histoire.
Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks
Authors: Zhao Suwen , Sakai Ayano , Zhang Xinshuai , Vetting Matthew W , Kumar Ritesh , Hillerich Brandan , San Francisco Brian , Solbiati Jose , Steves Adam , Brown Shoshana , Akiva Eyal , Barber Alan , Seidel Ronald D , Babbitt Patricia C , Almo Steven C , Gerlt John A , Jacobson Matthew P
Published: June 2014

Metabolic pathways in eubacteria and archaea often are encoded by operons and/or gene clusters (genome neighborhoods) that provide important clues for assignment of both enzyme functions and metabolic pathways. We describe a bioinformatic approach (genome neighborhood network; GNN) that enables large scale prediction of the in vitro enzymatic activities and in vivo physiological functions (metabolic pathways) of uncharacterized enzymes in protein families. We demonstrate the utility of the GNN approach by predicting in vitro activities and in vivo functions in the proline racemase superfamily (PRS; InterPro IPR008794). The predictions were verified by measuring in vitro activities for 51 proteins in 12 families in the PRS that represent ~85% of the sequences; in vitro activities of pathway enzymes, carbon/nitrogen source phenotypes, and/or transcriptomic studies confirmed the predicted pathways. The synergistic use of sequence similarity networks3 and GNNs will facilitate the discovery of the components of novel, uncharacterized metabolic pathways in sequenced genomes.
The world in Arab eyes: A reassessment of the climes in medieval Islamic scholarship
Authors: Olsson J.T.
Published: June 2014

Many Arabic geographical texts from the medieval period portray the oecumene as comprising seven latitudinal climes. In general the middle clime, in which the majority of Muslim territories were located, was viewed as possessing the best environmental conditions, which progressively deteriorated the further one travelled north or south of this central territory. This theory of the climes was combined with ideas of humoral pathology in order to argue that those living in the central zones of the oecumene received numerous physiological and psychological benefits. Conversely, those like the Africans and the Turks, living at the peripheries of the oecumene, had neither rationality nor proportionate physiognomies because their humours were distorted by the harsh environmental conditions of these regions. This article, however, seeks to nuance the outline given above. While secondary studies have generally been happy to adopt uncritically this superficial understanding of the medieval Islamic worldview, which is gained from skimming the introductions to a few geographical works, few have questioned what (and where) is meant by the centre of the world, where did human habitation supposedly end, and was the medieval understanding of the seven climes uniform. These are some of the questions posed by the present investigation. I then go on to assess how far the notions derived from the theory of the climes were implemented in ethnological accounts of the inhabitants of the far north and south. In doing so I shall conclude that the standard conception of the medieval Islamic worldview masks numerous disagreements and debates in the writings of medieval scholars.
Regional population health index as a major factor in planning the health care system
Authors: Петрашенко Дмитрий , Petrashenko Dmitriy , Левин Исраиль , Levin Israil , Пономарева Юлия , Ponomareva Yuliya
Published: June 2014

The health care system of the country and the development of Health must take into account the distribution and planning costs for medical services. The selection of these indicators takes into account the health index as part of the integral index of quality and standard of living, as measured by life expectancy at birth , and at the regional level. At this level of measurement of health, regions should not be limited to one exponent and objectively consider more of them.
Command Structure Design of a Robot for the Vibro-Acoustic with Scanning Testing
Authors: Comeagă Daniel Constantin , Udrea Constantin , Donţu Octavian , Necula Cristian
Published: June 2014

This paper is presenting the command system improvement of a scanning robot for acoustical testing. The evaluation of noise emitted by an object by measuring the acoustic intensity according with the ISO 9614-3:2002 international standard requires displacement of the probe on spatial trajectories with constant speed and maintaining the spatial orientation of the probe. In a previous work a robot was design by the authors for performing this task, including a unit with 3 translations and an orientation unit with 2 rotations.The practical tests of the first system shown high difficulties in maintaining the constant speed due to the robot dimensions and inertia. Also the noise produced by the translational units during scanning was too high. The system is improved by adding 1 degree of freedom at the orientation unit, reduction of noise and new software version. The new mechanical structure is the subject of another paper. This article is presenting the control system of the robot based on Festo controllers, DSP board and programs derived using LabVIEW. The new version is based on a positioning of the scanning unit in the vicinity of the scanning plane, using translation axis, and then the displacement of the acoustic probe for scanning using only the orientation unit, having DC motors, much lower inertia. This allowed a better control of scanning and lower noise.
Mesoscopic Simulation Analysis of the Influence of Die Wall Friction on Compression Process of Powder Particles
Authors: Jiao Ming Hua , Li Da , Sun Long , Gu Man
Published: June 2014

Discrete element method is applied to investigate the rules of particle flowing by using mesoscopic simulation in the process of compaction. The strain processes,the deformation differences of the particles in typical positions, and the porosities change in different areas under various Die-wall friction coefficients were investigated. The results showed that Die-wall interface friction causes diagonal flow of particles from upper surface edges to the center of compact, which has a significant influence on deformation and density uniformity of powder particles.
A Laser TV Signal Dynamic Filtering Based on FPGA
Authors: Han Shi Jie , Yu Yi Zhong , Xue Chao
Published: June 2014

The regular TV signal is converted to a Laser TV signal, the displayed video after conversion is not perfect and jitters in serious condition. The converted image is not clear, and there also exists chromatic aberration. According to gamut mapping matrix, this paper presents a dynamic real-time signal processing filter, which eliminates the noise generated in the color gamut mapping. It can effectively handle signals mapped to reduce errors and eliminate noise. We verified the feasibility of this design on a development board of Virtex-5 FPGA chip as the core ML50x.