bluuebunny/crossref_metadata_2025 huggingface dataset:
Content-based information retrieval and anonymisation in data and multimedia streams
Authors: Ζυγομήτρος Αθανάσιος
Published: October 2021

Προσωπικά δεδομένα είναι οποιαδήποτε πληροφορία μπορεί να χρησιμοποιηθεί για την αναγνώριση ενός ατόμου. Αυτά τα δεδομένα μπορούν να λάβουν διάφορες μορφές, όπως ένα πεδίο σε μια βάση δεδομένων, έναν μοναδικό αριθμό, μια φωτογραφία ή ένα πακέτο δικτύου. Τα προσωπικά δεδομένα σχετικά με τα άτομα συλλέγονται και διαχειρίζονται από οργανισμούς στον ιδιωτικό και δημόσιο τομέα. Οι επιχειρήσεις και η επιστημονική κοινότητα έχουν μια ακόρεστη δίψα για δεδομένα. Με τους προηγμένους αλγόριθμους εξόρυξης δεδομένων νέα γνώση μπορεί να αποκαλυφθεί από αυτά τα δεδομένα. Πρέπει να σημειωθεί ότι αυτά τα δεδομένα δεν μπορούν να δημοσιευθούν χωρίς την δέουσα προσοχή αφού υπάρχει πάντα ο κίνδυνος παραβίασης της ιδιωτικής ζωής των ατόμων. Ένας επιστημονικός τομέας αναδείχθηκε, αυτός της ανωνυμοποίησης δεδομένων, για να καλύψει την ανάγκη της προστασίας της ιδιωτικότητας σε δεδομένα που δημοσιεύονται. Η διαδικασία της ανωνυμοποίησης θα πρέπει να εξισορροπήσει την προστασία της ιδιωτικότητας των ατόμων με τη χρησιμότητα του δημοσιευμένου συνόλου δεδομένων. Αυτές οι τεχνικές ανωνυμοποίησης αναλύονται και παρουσιάζονται τα πλεονεκτήματα και μειονεκτήματα τους. Η συμβολή αυτής της διατριβής στο επιστημονικό πεδίο της δημοσίευσης δεδομένων είναι διττή. Πρώτον, την εισαγωγή μιας νέας επίθεσης σε ανωνυμοποιημένα δεδομένα, που ονομάζεται επίθεση συμπερασμού των οιονεί αναγνωριστικών, inference of QI attack, που δείχνει ότι μια αυτοματοποιημένη λύση ανωνυμοποίησης, ειδικά για ιατρικά δεδομένα, είναι δύσκολο να επιτευχθεί χωρίς να ληφθεί υπόψη η σημασιολογία των δεδομένων και χωρίς την συμβολή των εμπειρογνωμόνων του τομέα. Δεύτερον, η ανάπτυξη ενός νέου αλγορίθμου που υλοποιεί km-anonymisation λαμβάνοντας υπόψη τις ιδιότητες των συνεχών χαρακτηριστικών και χωρίς να προαπαιτεί μια ιεραρχία γενίκευσης. Μετά από διεξαγωγή πειραμάτων φαίνεται ότι ο νέος αλγόριθμός διατηρεί περισσότερες πληροφορίες στο δημοσιευμένο σύνολο δεδομένων σε σύγκριση με άλλους αλγόριθμους ανωνυμοποίησης που χρησιμοποιούν ιεραρχίες γενίκευσης. Τα πολυμέσα είναι ένας άλλος τύπος προσωπικών δεδομένων που επίσης εξετάστηκε σε αυτή την έρευνα. Συγκεκριμένα από τα πολυμέσα που διαμοιράζονται στα Online Κοινωνικά Δίκτυα προκύπτουν πολλοί κίνδυνοι ιδιωτικότητας. Παρουσιάζεται μια αναλυτική έρευνα για τους κινδύνους αυτούς και προτείνεται μια λύση με βάση την ψηφιακή υδατογράφηση για την εξάλειψη πολλών από αυτούς τους κινδύνους. Τα έξυπνα τηλέφωνα με την συνεχώς αυξανόμενη υπολογιστική δύναμη συνδυάζονται με αισθητήρες, όπως το GPS, προσφέροντας νέες ευκαιρίες για ανάπτυξη κινητών εφαρμογών με νέες δυνατότητες. Για να δείξουμε πώς μπορεί να παραβιαστεί το απόρρητο ενός χρήστη, επικεντρώσαμε την προσοχή μας σε έναν τομέα ευαίσθητο στην ιδιωτικότητα των εφαρμογών, των εφαρμογών που χρονολογούνται. Η έρευνα βασίζεται στα μεταδιδόμενα πακέτα δικτύου και τα αποτελέσματα είναι ανησυχητικά.
Πολιτιστική συμμετοχή και ποιότητα ζωής
Authors: Παλιάτσιος Γεώργιος
Published: October 2021

Στην παρούσα διατριβή τέθηκε ως στόχος, η διαμόρφωση σαφούς εικόνας για τη σύνδεση των δραστηριοτήτων Πολιτιστικής Συμμετοχής με την Ποιότητα Ζωής και συγκεκριμένα την αίσθηση Ευζωίας, στους φοιτητές ελληνικού πανεπιστημίου. Για τη διερεύνηση αυτής της σύνδεσης πραγματοποιήθηκε παρέμβαση Τέχνης Κοινοτικής-βάσης με ψυχοπαιδαγωγικό σχεδιασμό και εφαρμογή, σε κοινότητα 32 φοιτητών του Πανεπιστημίου Δυτικής Μακεδονίας. Η διάρκεια της παρέμβασης ήταν επτά συναντήσεις σε διάστημα δύο μηνών και η διερεύνηση της έγινε μέσα από τη συλλογή ποσοτικών και ποιοτικών δεδομένων, τόσο από την «ομάδα στόχο» όσο και από την αξιοποίηση «ομάδας ελέγχου» 30 ατόμων, αντίστοιχων χαρακτηριστικών. Για τη συλλογή των ποσοτικών δεδομένων χρησιμοποιήθηκαν δύο ερευνητικά εργαλεία: ένα ερωτηματολόγιο για την Πολιτιστική Συμμετοχή, προσαρμοσμένο στις ανάγκες της έρευνας και το ερωτηματολόγιο Mental Health Continuum-Sort Form (MHC-SF). Η συλλογή των ποιοτικών δεδομένων, έγινε κυρίως μέσα από τη χορήγηση συνεντεύξεων στους συμμετέχοντες και των δύο ομάδων (n=62), αλλά και μέσα από αξιολόγηση που παρείχαν οι φοιτητές της παρέμβασης. Οι χορηγήσεις των ερευνητικών εργαλείων, πραγματοποιήθηκαν πριν και αμέσως μετά την παρέμβαση, ενώ πραγματοποιήθηκε ένα χρόνο μετά, follow-up χορήγηση στα εργαλεία της ποσοτικής διερεύνησης. Στα αποτελέσματα, τα ποσοτικά ευρήματα εμφανίζουν απουσία σύνδεσης των δραστηριοτήτων Πολιτιστικής Συμμετοχής των φοιτητών με την Ποιότητα Ζωής τους. Ωστόσο, η ποιοτική διερεύνηση δείχνει ότι οι φοιτητές αντιλαμβάνονται την Πολιτιστική Συμμετοχή να επιδρά στην αίσθηση Ευζωίας τους και στον Αυτοπροσδιορισμό τους. Από την άλλη, οι συμμετέχοντες μετά την παρέμβαση, εμφανίζουν μικρή έως μέτρια βελτίωση στην αίσθηση της συνολικής Ευζωίας και σε κάθε μία από τις διαστάσεις της, σε σχέση με τους φοιτητές της «ομάδας ελέγχου», όπου εμφανίζεται μείωση στην ίδια αίσθηση. Αντίστοιχα είναι τα αποτελέσματα για την ψυχική υγεία. Η διερεύνηση που πραγματοποιήθηκε, υποδεικνύει ότι αν και οι φοιτητές αντιλαμβάνονταν ότι η Πολιτιστική Συμμετοχή επιδρά ευεργετικά στην Ποιότητα Ζωής τους, το πλήθος των δραστηριοτήτων που εξασκούσαν δεν ήταν από μόνο του αρκετό για να τους ευνοήσει. Η εφαρμογή, ωστόσο, των δομημένων δραστηριοτήτων Τέχνης Κοινοτικής–βάσης ψυχοπαιδαγωγικού σχεδιασμού, παρουσιάστηκε ικανή να αποδώσει οφέλη στην Ευζωία και την ψυχική υγεία της κοινότητας των φοιτητών. Η περαιτέρω μελέτη και εφαρμογή παρόμοιων δράσεων, συνίσταται για την επιδίωξη της θετικής κοινωνικής αλλαγής.
Prediction of Tensile Strength of 3D Printed Bronze PLA Part Using Response Surface Modelling
Authors: Palanisamy Chockalingam , Nagarajan Sugendran
Published: October 2021

Background - 3D printing is a dynamic process with many process parameters influencing the product, including the type of the material; it is often difficult to understand the combined influence of these parameters.  

Purpose - The tensile strength of 3D printed parts is important for the functionality of components. The effects of process parameters on tensile strength must therefore be examined. The objective of this study is to develop a response surface model (RSM) to predict the final quality of a 3D printed bronze part from a different set of input parameters.  

Methods - The tensile test specimen was built in a Makerbot 3D printer with bronze polylactic acid (PLA) material. The three controllable input parameters were; thickness of layers, number of shells, and infill density. The three levels of layer thickness were 0.1mm, 0.2mm and 0.3mm. The number of shells was 2, 3 and 4. The infill densities were 20%, 30% and 40%. A tensile experiment tested the strength of the specimens. RSM is a statistical approach for modelling and analyzing how different variables affect the response of interest, and for optimizing it.  

Results - The result obtained shows that the specimen with a high layer thickness of 0.3mm and infill density of 40% is the best among all the other parameters. Finally, the regression equation produced was used for random values of layer thickness, the number of shells, and infill density, to see whether the values obtained from the tests fall into the range of experimental data.  

Conclusion - Infill density and layer thickness are the two criteria that significantly influence the tensile property. The number of shells has the least influence on the tensile property. However, the best tensile strength is the part printed with higher infill density, a greater number of shells, and higher layer thickness.
Self-management interventions for Type 2 Diabetes: systematic review protocol focusing on patient workload and capacity support
Authors: Hanlon Peter , Bryson Iona , Morrison Holly , Rafiq Qasim , Boehmer Kasey , Gionfriddo Michael R , Gallacher Katie , May Carl , Montori Victor , Lewsey Jim , McAllister David A , Mair Frances S
Published: October 2021

Introduction:

People living with type 2 diabetes undertake a range of tasks to manage their condition, collectively referred to as self-management. Interventions designed to support self-management vary in their content, and efficacy. This systematic review will analyse self-management interventions for type 2 diabetes drawing on theoretical models of patient workload and capacity.

Methods and analysis:

Five electronic databases (Medline, Embase, CENTRAL, CINAHL and PsycINFO) will be searched from inception to 27th April 2021, supplemented by citation searching and hand-searching of reference lists. Two reviewers will independently review titles, abstracts and full texts. Inclusion criteria include Population: Adults with type 2 diabetes mellitus; Intervention: Randomised controlled trials of self-management support interventions; Comparison: Usual care; Outcomes: HbA1c (primary outcome) health-related quality of life (QOL), medication adherence, self-efficacy, treatment burden, healthcare utilization (e.g. number of appointment, hospital admissions), complications of type 2 diabetes (e.g. nephropathy, retinopathy, neuropathy, macrovascular disease) and mortality; Setting: Community. Study quality will be assessed using the Effective Practice and Organisation of Care (EPOC) risk of bias tool. Interventions will be classified according to the EPOC taxonomy and the PRISMS self-management taxonomy and grouped into similar interventions for analysis. Clinical and methodological heterogeneity will be assessed within subgroups, and random effects meta-analyses performed if appropriate. Otherwise, a narrative synthesis will be performed. Interventions will be graded on their likely impact on patient workload and support for patient capacity. The impact of these theoretical constructs on study outcomes will be explored using meta-regression.

Conclusion

This review will provide a broad overview of self-management interventions, analysed within the cumulative complexity model theoretical framework. Analyses will explore how the workload associated with self-management, and support for patient capacity, impact on outcomes of self-management interventions.

Registration number:

PROSPERO CRD42021236980.
Szkoły i studia na włoskim szlaku 2 Korpusu Polskiego
Authors: Draus Jan
Published: October 2021

W niniejszej publikacji przedstawiono zarys problematyki związanej z edukacyjną działalnością 2 Korpusu Polskiego na terenie Włoch. W poszczególnych dywizjach 2 Korpusu funkcjonowało szkolnictwo ogólnokształcące, zawodowe, a ponadto żołnierze odbywali studia na uczelniach włoskich. 2 Korpus gen. Władysława Andersa nie tylko wsławił się na polach bitew, zdobywając m.in. Monte Cassino czy wyzwalając wiele włoskich miast, ale także poprzez działalność edukacyjną przygotował żołnierzy do życia cywilnego w kraju i na obczyźnie.
Uznawanie przez Hiszpanię rządu Rzeczypospolitej Polskiej na uchodźstwie w latach 1945–1968. Historia pewnego mitu
Authors: Ciechanowski Jan Stanisław
Published: October 2021

W latach 1942–1943 stosunki dyplomatyczne między Polską i Hiszpanią zostały zawieszone. Po cofnięciu uznania rządowi RP w Londynie gabinet w Madrycie nie uczynił tego i w latach 1945–1968 pozostawał z polskim poselstwem w stolicy Hiszpanii (w latach 1955–1961 z dwoma) w relacjach półoficjalnych. Przedstawiciele RP nie znajdowali się na liście korpusu dyplomatycznego, za mit należy więc uznać, iż dyktatura gen. Francisco Franco utrzymywała stosunki dyplomatyczne z rządem RP na uchodźstwie.
Subclinical Rejection and Immunosuppression in Pediatric Kidney Transplant Recipients : Single Centre Study
Authors: Fadel Fatina I , Abd ElBaky Abeer M Nour ElDin , Abdel Mawla Mohamed  A , Moustafa Wesam I , Saadi Gamal Eldin , Salah Doaa M
Published: October 2021

Background: By the time of histological confirmation of rejection is achieved, renal scarring may for treatment as a realistic option . This study aims to study the subclinical pathological graft data and to evaluate the histopathological impact of different immunosuppression protocols in pediatric renal transplant recipients. Methods: This is a case series that included twenty living donor renal transplant recipients. All included cases received the classic triple immunotherapy for at least one month post-transplantation [Steroids, calconurine inhibitors (CNI), and mycofenlolic mofetile (MMF)]. Based on their immunological risk stratification; included cases were divided into 2 groups: group (A) continued on CNI based triple therapy protocol; group (B) shifted to evirolimus /low dose CNI protocol. Surveillance biopsies were done for all cases at one and four month post-transplantation. Results: One and four month biopsies revealed subclinical rejection (including borderline changes) in 4 (20%) cases and 6 (30%) cases respectively. The number of patients received tacrolimus/MMF therapy significantly increased (p=0.02) while that of patients on everloimus/low dose CNI significantly decreased (p=0.014) due to drug modifications based on four month surveillance biopsy data. Conclusion: Subclinical rejection is not uncommon in pediatric renal graft recipients which makes surveillance biopsy might be of help. Early usage of evirolimus/low CNI protocol is associated with higher rejection rate than triple therapy.
A Study on High and Low level Drug Resistance Pattern Among Clinical Isolates of Enterococci .
Authors: Rajan Reena , Karthikeyan D
Published: October 2021

Introduction: The combined abilities of colonisation and both inherent and acquired resistance have made Enterococci a significant human pathogen. Aims and Objectives: This study was done to determine the Minimum Inhibitory Concentration of various antibiotics against Enterococci and to correlate the phenotypic and genotypic characteristics of Enterococci with low level and high level drug resistance. Materials and Methods: A total of 774 isolates of Enterococci obtained from various clinical samples were subjected to antimicrobial susceptibility testing by Kirby Bauer Disk Diffusion method. The Minimum Inhibitory Concentration of various antibiotics were determined by Vitek 2 automated system, agar dilution and E test. Results: 15 out of 774 isolates showed the presence of vancomycin resistant genes by Multiplex PCR. 10 (90.91 %) isolates out of 11 E. faecalis with van A gene showed high level resistance to Penicillin (16-64 µg/ml). 8 (72.73 %) out of 11 isolates showed high level resistance to Gentamicin (512-1024 µg/ml). 6 (54.55 %) , out of 11 isolates were resistant to β lactams. One isolate of E. faecalis from urine with van B gene showed showed high level resistance to Penicillin (32 µg/ml), Linezolid (≥ 8µg/ml), high level resistance to Gentamicin (1024 µg/ml), Fluoroquinolones (≥ 8µg/ml) and Macrolides (≥ 8µg/ml). Conclusion: Isolates of Enterococci resistant to glycopeptides, penicillin, Betalactams and aminoglycosides have important clinical implications in the treatment for infection.
The Effect of Regular Physical Activity on the Cardiovascular System in Students
Authors: Pryanikova Natalia G. , . Dorontsev Alexander V , Marandykina Oksana V. , L. Volobuev Alexey , I. Sharagin Victor , N. Komarov Mikhail
Published: October 2021

It has been noticed that dosed muscle activity in the form of regular physical culture exercises is capable of providing a pronounced general health-improving effect at any age. Neglect of systematic rational physical activity always contributes to a persistent weakening of the state of health and especially often leads to the formation of various dysfunctions of the heart and blood vessels. The study was carried out in 2019-2020 on young men living in Central Russia (the city of Moscow and the Moscow region). In the work carried out, it was found that regular muscle activity in healthy adolescents and those with dysfunctions in the cardiovascular system provides a stable normalization of the parameters of cardiac activity. As a result of regular dosed physical training, all those under observation had a statistically significant increase in the vital capacity of the lungs. All physically training young men showed an increase in the level of general physical fitness. In all cases, the boys who increased their physical activity showed an increase in speed-strength capabilities and an increase in overall endurance. It can be considered that an increase in daily physical activity due to an increase in the distance covered on foot is a very effective means of improving the health of adolescents, including when they begin to develop disorders of the cardiovascular system.
A Comparative Study of Safety and Efficacy of Oral Terbinafine and Itraconazole in Patients of Tinea Corporis/ Tinea Cruris Infection, A Randomized Open Label Parallel Group Study
Authors: Brigida S. , Elizabeth Arul Amutha , Soujania G. , Poornima R. Poornima
Published: October 2021

Introduction: Superficial dermatophytosis is a common public health problem in India, due to its tropical climate with heat and humidity. Today, the triazoles, mainly Itraconazole and the allylamines, chiefly Terbinafine, are the main ammunitions against dermatophytes. This study is undertaken to compare the safety and efficacy of both the drugs. Materials and Methods: This study was conducted to find the efficacy of Oral Terbinafine and Oral Itraconazole in Tinea Corporis/Tinea Cruris infection. The primary efficacy parameter was change in composite score (pruritus, erythema, pigmentations) from baseline to end of the treatment period. And to compare the safety of Oral Terbinafine and Oral Itraconazole by comparing the following parameters, Liver enzymes - SGOT/SGPT before and after treatment with the study drugs. Drug Dosage: Group 1: Drug –Tab. Terbinafine: Dose 500 mg per day once daily at bedtime for 2 weeks. Group 2: Drug –Tab. Itraconazole: Dose 200 mg per day, once daily at bedtime for 2 weeks. Results: The study participants show significant reduction in itching at the second follow up (after 2 weeks of drug completion) in both groups. Pruritis was reduced in 92% subjects in group 1 and 97.5% subjects in group 2. There was 87% reduction in erythema in group 1 and 93% reduction in group 2. Pigmentations were seen in 2% subjects in both groups indicating relapse of infection. Conclusion: The significant outcome of the study was that oral Itraconazole 200mg/day for 14 days(2 weeks) can be the better antifungal.
Seroprevalence of Cytomegalovirus Antibodies Among COVID-19 Patients
Authors: Ibrahim Mohamed N.
Published: October 2021

One of the biggest infectious diseases for humans in modern history is the COVID-19 pandemic. The disease mechanisms of human viral infections have been modified by virus-virus interaction. This study was carried out to detect the seroprevalence of CMV in COVID-19 patients. A total of 105 cases (58 females and 47 males) with an age range of 17-65 years (mean age 39.52±11.02 years) were included in this study. HCMV-IgG and IgM were determined in subjects' cases. Sixty-five out of 105 (62%) were positive for SARS-CoV-2, while 40 (38%) had negative SARS-CoV-2. Forty-seven (72.3%) and 11 (16.9%) cases out of 65 SARS-CoV-2 positive patients were positive for CMV-IgG and IgM antibodies, respectively. No significant differences were noted between females and males in terms of seroprevalence rates. A high rate of positive CMV-IgG was observed among 40-64 years COVID-19 patients. It is concluded that the seroprevalence of CMV antibodies amongst COVID-19 cases is high in relation to findings in cases without SARSCoV-2.
Surface modification and effects on tribology by laser texturing in Al2O3
Authors: Jing Xiubing , Zhai Qilei , Zheng Shuxian , Zhang Du , Qi Huan , Zhang Dawei
Published: October 2021

We investigate the surface modification by laser texturing and effects thereof on the tribological performance in

A
l

2

O

3

. By detailed observation for microstructure evolution, it has been shown that there were three distinct modification morphologies by laser treatment: dense surface microfeatures, “coral” dendritic structures, and coarse grains. X-ray diffraction (XRD) results indicated that there was no formation of metastable phases due to low supercooling in solidification in the nanosecond laser regime. The formation of AlN compounds in the laser-treated region was examined by using x-ray photoelectron spectroscopy (XPS), which led to dense surface microfeatures and randomly distributed pores formation in the laser treated region. The formation of “coral” dendritic structures on the edge of groove and coarse grains in the vicinity of the laser surface was attributed to the fast-cooling rates. Wear tests were carried out to analyze the effect of laser texturing on tribological performance. The results of coefficients of friction (COF) illustrated that laser texturing can significantly improve COFs for dry friction; however, it decreases the COFs for wet friction. The mechanism of wear was explained based on a SEM measurement for worn surfaces; the formation of surface texture can store abrasive particles and debris lead to hydrodynamic lubricant film formation and the COFs significantly reducing for wet friction.
Semi-analytical model of the optical properties of a metasurface composed of nanofins
Authors: Borne Jeck , Panneton Denis , Piché Michel , Thibault Simon
Published: October 2021

We propose a method to evaluate the optical propagation properties of a dielectric non-resonant metasurface composed of rectangular nanofins. Our approach is based on a semi-analytical assessment of the effective indices to perform guided vectorial propagation inside the nanostructure. The proposed model is an extension of the commonly used Pancharatnam–Berry model where the effect of the incidence angle can be satisfactorily accounted for. The model shows good agreement with numerical simulations, and it can be inverted to give the nanofin rotation angle for a given output phase function. We show that the far-field distribution of a metalens predicted by our model is in good agreement with data from a simulation code.
Ultra-compact in-core-parallel-written FBG and Mach–Zehnder interferometer for simultaneous measurement of strain and temperature
Authors: Tian Ke , Zhang Mingyuan , Zhao Zhiyuan , Wang Ruoning , Liu Dejun , Wang Xin , Lewis Elfed , Farrell Gerald , Wang Pengfei
Published: October 2021

An ultra-compact in-core-parallel-written fiber Bragg grating (FBG) and Mach–Zehnder interferometer (MZI) for simultaneous measurement of strain and temperature is described. The FBG and MZI are written spatially parallel in the same section of fiber core using a femtosecond laser, forming an ultra-compact device, which is different from the previously developed axial cascade of different structures. Due to the weak coupling between the FBG and the MZI, their individual extinction ratios are traded off by optimizing their writing position and separation, and extinction ratios of 5.9 dB for the FBG and 10 dB for the MZI are achieved. Experimental results show that the FBG and MZI have different sensitivities for strain and temperature, allowing this device to measure strain and temperature simultaneously. In addition, since both the FBG and MZI are written in the fiber core, this ultra-compact device is proven to be impervious to ambient humidity, making it a promising candidate for accurate industrial strain and temperature measurements.
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
Authors: Jack Amanda , Ferro Luke S. , Trnka Michael J. , Wehri Eddie , Nadgir Amrut , Nguyenla Xammy , Fox Douglas , Costa Katelyn , Stanley Sarah , Schaletzky Julia , Yildiz Ahmet
Published: October 2021

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a pandemic that seriously threatens global health. SARS-CoV-2 propagates by packaging its RNA genome into membrane enclosures in host cells. The packaging of the viral genome into the nascent virion is mediated by the nucleocapsid (N) protein, but the underlying mechanism remains unclear. Here, we show that the N protein forms biomolecular condensates with viral genomic RNA both in vitro and in mammalian cells. While the N protein forms spherical assemblies with homopolymeric RNA substrates that do not form base pairing interactions, it forms asymmetric condensates with viral RNA strands. Cross-linking mass spectrometry (CLMS) identified a region that drives interactions between N proteins in condensates, and deletion of this region disrupts phase separation. We also identified small molecules that alter the size and shape of N protein condensates and inhibit the proliferation of SARS-CoV-2 in infected cells. These results suggest that the N protein may utilize biomolecular condensation to package the SARS-CoV-2 RNA genome into a viral particle.
Frank-Starling mechanism, fluid responsiveness, and length-dependent activation: Unravelling the multiscale behaviors with an in silico analysis
Authors: Kosta Sarah , Dauby Pierre C.
Published: October 2021

The Frank-Starling mechanism is a fundamental regulatory property which underlies the cardiac output adaptation to venous filling. Length-dependent activation is generally assumed to be the cellular origin of this mechanism. At the heart scale, it is commonly admitted that an increase in preload (ventricular filling) leads to an increased cellular force and an increased volume of ejected blood. This explanation also forms the basis for vascular filling therapy. It is actually difficult to unravel the exact nature of the relationship between length-dependent activation and the Frank-Starling mechanism, as three different scales (cellular, ventricular and cardiovascular) are involved. Mathematical models are powerful tools to overcome these limitations. In this study, we use a multiscale model of the cardiovascular system to untangle the three concepts (length-dependent activation, Frank-Starling, and vascular filling). We first show that length-dependent activation is required to observe both the Frank-Starling mechanism and a positive response to high vascular fillings. Our results reveal a dynamical length dependent activation-driven response to changes in preload, which involves interactions between the cellular, ventricular and cardiovascular levels and thus highlights fundamentally multiscale behaviors. We show however that the cellular force increase is not enough to explain the cardiac response to rapid changes in preload. We also show that the absence of fluid responsiveness is not related to a saturating Frank-Starling effect. As it is challenging to study those multiscale phenomena experimentally, this computational approach contributes to a more comprehensive knowledge of the sophisticated length-dependent properties of cardiac muscle.
An approach to increase the power output of Karnafuli Hydroelectric Power Station: A step to sustainable development in Bangladesh’s energy sector
Authors: Hossain Fakir Sharif , Rahman Tahmidur , Mamun Abdullah Al , Mannan Omar Bin , Altaf-Ul-Amin M.
Published: October 2021

Renewable energy has become the most prominent source of energy to reduce carbon emissions around the globe. Undoubtedly, hydro energy is very much clean energy among other sources. In Bangladesh, hydro energy is available only in a specific southern area contributing several hundred megawatts to the national grid. This paper devotes to assessing the capacity and practicability of a hydropower plant to boost the power output by implementing the combined cycle hydropower system. The proposed method has been developed by 1) studying the existing plant based on surveyed data, 2) selecting the site for installing the hydrokinetic turbine, 3) designing with consideration of numerous constraints of inter dependability, and 4) creating a prototype model to ensure the practicability. Preliminary results show that a significant amount of additional electric energy can be generated from the plant with higher efficiency.
Distinct responses of frond and root to increasing nutrient availability in a floating clonal plant
Authors: Jin Yu , Zhang Qian , Zhang Li-Min , Lei Ning-Fei , Chen Jin-Song , Xue Wei , Yu Fei-Hai
Published: October 2021

Current knowledge on responses of aquatic clonal plants to resource availability is largely based on studies manipulating limited resource levels, which may have failed to capture the “big picture” for aquatic clonal plants in response to resource availability. In a greenhouse experiment, we grew the floating clonal plantSpirodela polyrhizaunder ten nutrient levels (i.e., 1/64×, 1/32×, 1/16×, 1/8×, 1/4×, 1/2×, 1×, 2×, 4× and 8×full-strength Hoagland solution) and examined their responses in terms of clonal growth, morphology and biomass allocations. The responses of total biomass and number of ramets to nutrient availability were unimodal. A similar pattern was found for frond mass, frond length and frond width, even though area per frond and specific frond area fluctuated greatly in response to nutrient availability. In contrast, the responses of root mass and root length to nutrient availability were U-shaped. Moreover,S.polyrhizainvested more to roots under lower nutrient concentrations. These results suggest that nutrient availability may have distinct influences on roots and fronds of the aquatic clonal plantS.polyrhiza, resulting in a great influence on the wholeS.polyrhizapopulation.
Sustained effects of an early childhood language and literacy intervention through second grade: Longitudinal findings of the SPELL trial in Denmark
Authors: Bleses Dorthe , Dale Philip S. , Justice Laura , Højen Anders , Vind Benedicte D. , Jiang Hui
Published: October 2021

Predictive relations between language and literacy skills during the preschool years and children’s future reading achievement are well-documented, leading to development and evaluation of preschool interventions targeting early skill development. Although educational researchers have developed and found some positive short- and mid-term effects of language and literacy intervention supplements implemented in early childhood education (ECE) settings, fade-out is a concern. Most studies have targeted children experiencing risk, rather than a more representative sample. Additionally, there are very few studies of long-term intervention effects, and heterogeneity of long-term effects has not been well described. In the present study, we build on initial reports of one of the largest studies of a language and literacy intervention supplement, the SPELL randomized controlled trial implemented as part of the universal ECE system in Denmark. SPELL was delivered to an unselected sample of children at 3–5 years of age (n =7,076). Results of the base intervention (SPELL) and two enhanced versions featuring extended professional development for teachers (SPELL+PD) or an add-on home-based program for parents (SPELL+HOME) showed short-term effects for literacy outcomes for all children for all SPELL conditions compared to business as usual (BAU). In this follow-up study, we utilized follow-up assessments of 2,700 SPELL 4-5-year-old participants with national reading tests in second grade. The main analyses based on the whole sample showed no significant differences in reading scores in second grade for those in any of the three SPELL conditions relative to the BAU condition. However, moderation analyses demonstrated heterogeneity in intervention effects with children whose mothers had low-mid education showing sustained and mostly large-sized effects. Other risk factors, including income and immigrant background, and condition interacted with at least one outcome variables. These findings suggest that at-risk children in some cases derive long-term benefits from early language and literacy intervention enhancing learning opportunities in ECE settings.
Neuroinductive properties of mGDNF depend on the producer, E. Coli or human cells
Authors: Shamadykova Dzhirgala V. , Panteleev Dmitry Y. , Kust Nadezhda N. , Savchenko Ekaterina A. , Rybalkina Ekaterina Y. , Revishchin Alexander V. , Pavlova Galina V.
Published: October 2021

The glial cell line‐derived neurotrophic factor (GDNF) is involved in the survival of dopaminergic neurons. Besides, GDNF can also induce axonal growth and creation of new functional synapses. GDNF potential is promising for translation to treat diseases associated with neuronal death: neurodegenerative disorders, ischemic stroke, and cerebral or spinal cord damages. Unproductive clinical trials of GDNF for Parkinson’s disease treatment have induced to study this failure. A reason could be due to irrelevant producer cells that cannot perform the required post-translational modifications. The biological activity of recombinant mGDNF produced byE.colihave been compared with mGDNF produced by human cells HEK293. mGDNF variants were tested with PC12 cells, rat embryonic spinal ganglion cells, and SH-SY5Y human neuroblastoma cellsin vitroas well as with a mouse model of the Parkinson’s diseasein vivo. Bothin vitroandin vivothe best neuro-inductive ability belongs to mGDNF produced by HEK293 cells. Keywords: GDNF, neural differentiation, bacterial and mammalian expression systems, cell cultures, model of Parkinson’s disease.
Reflections on Filming in Svalbard
Authors: Schuppli Susan
Published: October 2021

Video stills from a journey taken in August 2020 with glaciologist Miriam Jackson during which time Susan Schuppli and Henry Bradley worked as crew while documenting the circumnavigation of Spitsbergen Island in the Svalbard Arctic Archipelago.
Performance Analysis of Different Hybrid Precoding Schemes in 5G mmWave massive MIMO Systems
Authors: Hoque Md. Mizanul , Karim Md. Masud , Kamal Md. Mustafa , Kayesh Md. , Osman Sawkat
Published: October 2021

Millimeter-wave (mmWave) communication is most likely to appear as a aspiring technology in the upcoming generation of cellular communication (5G). To confront several challenges (e.g., system complexity, energy consumption etc.), hybrid precoding is largely investigated in mmWave massive MIMO systems due to its low energy consuming nature and reduced system complexity.
A ordem do discurso na lógica do espaço urbano burguês
Authors: Carvalho Carlos Henrique de , Carvalho Luciana Beatriz de Oliveira Bar de
Published: October 2021

A ordem do discurso na lógica do espaço urbano burguês
Tendências espaciais recentes do processo de verticalização em Uberlândia
Authors: Ramires Júlio Cesar de Lima
Published: October 2021

Tendências espaciais recentes do processo de verticalização em Uberlândia
Estrutura pedológica e dinâmica hídrica do "Coval" do córrego da Fortaleza
Authors: Schneider Marilena , Silva Delcimar Bueno da
Published: October 2021

Estrutura pedológica e dinâmica hídrica do "coval" do córrego da Fortaleza
A espacialidade dos royalties da Exploração Petrolífera off-Shore
Authors: Ramirez Júlio Cesar de Lima
Published: October 2021

A espacialidade dos royalties da Exploração Petrolífera off-Shore
Praguicidas e Meio Ambiente - uma reflexão com crianças e jovens de Rio Claro/SP
Authors: Carvalho Maria Bernadete Sarti da Silva , Poltroniéri Lígia Celoria
Published: October 2021

Praguicidas e Meio Ambiente - uma reflexão com crianças e jovens de Rio Claro/SP
As transformações do centro de Uberlândia no contexto da expansão da cidade
Authors: Soares Beatriz Ribeiro , Ramires Julio César de Lima
Published: October 2021

As transformações do centro de Uberlândia no contexto da expansão da cidade
Considerações sobre a produção de Geografia Urbana em Minas Gerais
Authors: Soares Beatriz Ribeiro
Published: October 2021

Considerações sobre a produção de Geografia Urbana em Minas Gerais
Modo de producción capitalista, generación de resíduos y contaminación ambiental
Authors: Godoy Manuel Rolando Berríos
Published: October 2021

Modo de producción capitalista, generación de resíduos y contaminación ambiental
Zona agrícolas do Canton Patate, Província de Tungurahua, Equador: implicações na qualidade de vida e impacto ambiental
Authors: Poltroniéri Ligia Celória , Quintero Rosa Figueiroa de , Moreira Victor Hugo Yépes , Cordova Celso Santacruz
Published: October 2021

Zona agrícolas do Canton Patate, Província de Tungurahua, Equador: implicações na qualidade de vida e impacto ambiental
A situação jurídica e territorial da áreas indígenas de Minas Gerais
Authors: Menezes Maria Lúcia Pires
Published: October 2021

A situação jurídica e territorial da áreas indígenas de Minas Gerais
As geociências como vetor no processo educativo
Authors: Barcelos José Humberto
Published: October 2021

As geociências como vetor no processo educativo
Geoinformática e Educación: aspectos conceptuales de su relación en América Latina
Authors: Buzai Gustavo D. , Desjardins Dora Nelly Salvatierra de
Published: October 2021

Geoinformática e Educación: aspectos conceptuales de su relación en América Latina
Introdução aos sistemas de informação geográfica
Authors: Brito Jorge Luis Silva de , Rosa Roberto
Published: October 2021

Introdução aos sistemas de informação geográfica
Lixo: o que é o lixo?
Authors: Assunção Washington Luiz
Published: October 2021

Lixo: o que é o lixo?
Análise ambiental do córrego Buritizinho, Uberlândia
Authors: Schneider Marilena de Oliveira , Batista Ivone Tavares
Published: October 2021

Análise ambiental do córrego Buritizinho, Uberlândia
Circulação viária em áreas centrais de cidades de porte médio: a questão do pedestre
Authors: Ferreira William Rodrigues , Soares Beatriz Ribeiro
Published: October 2021

Circulação viária em áreas centrais de cidades de porte médio: a questão do pedestre
Fertilidade e compactação dos solos da microbacia do Córrego Pantaninho, em Iraí de Minas (MG)
Authors: Bernardino Andréa Ríspoli , Lima Samuel do Carmo
Published: October 2021

Fertilidade e compactação dos solos da microbacia do Córrego Pantaninho, em Iraí de Minas (MG)
A melhoria do ensino dos conteúdos geológicos das séries iniciais ao ensino médio
Authors: Lopes Juliana Chioca , Santos Adriano Rodrigues dos
Published: October 2021

A melhoria do ensino dos conteúdos geológicos das séries iniciais ao ensino médio
Solos de uma topossequência na Estação Ecológica do Panga: relações entre o material de origem, as formas de relevo e a vegetação
Authors: Borges Viviane Custódia , Ferreira Lezir Montes
Published: October 2021

Solos de uma topossequência na Estação Ecológica do Panga: relações entre o material de origem, as formas de relevo e a vegetação
Contaminação química de mananciais em Rio Claro (SP): a poluição ambiental por deposição de resíduos industriais no Aterro da Granja Rosada em Rio Claro (SP)
Authors: Barcelos José Humberto , Carneiro José Carlos de Carvalho , Carvalho Pompeu Figueiredo de , Marconato José Carlos , Costa José Luiz Riani , Mauro Claudio Antônio di
Published: October 2021

Contaminação química de mananciais em Rio Claro (SP): a poluição ambiental por deposição de resíduos industriais no Aterro da Granja Rosada em Rio Claro (SP)
O pensamento geográfico e Euclides da Cunha: resgatar é preciso
Authors: Antônio  Filho Fadel Davis
Published: October 2021

O pensamento geográfico e Euclides da Cunha: resgatar é preciso
A verticalização de São Paulo e o cinema: uma nova dimensão no estudo das cidades
Authors: Ramires Julio César de Lima
Published: October 2021

A verticalização de São Paulo e o cinema: uma nova dimensão no estudo das cidades
A expansão urbana de Uberlândia e a ação da imobiliária Tubal Vilela
Authors: Martins Ieda Carla , Ramires Julio Cesar de Lima , Soares Beatriz Ribeiro
Published: October 2021

A expansão urbana de Uberlândia e a ação da imobiliária Tubal Vilela
El poder de los cuerpos: el desarrollo de la sexualidad y la práctica del aborto en Del rojo de su sombra de Mayra Montero, Wide sargasso sea de Jean Rhys y Moi, Tituba, sorcière… Noire de Salem de Marysé Condé. Un estudio comparado.
Authors: Swindt Pamela
Published: October 2021

En este trabajo se analizan las manifestaciones de la sexualidad y la práctica del aborto como elementos de subversión respecto al sistema opresivo colonial y patriarcal que constriñe la libertad de las mujeres protagonistas en tres textos literarios producidos por escritoras caribeñas: Del rojo de su sombra (1992) de Mayra Montero, Wide Sargasso Sea (1966) de Jean Rhys y Moi, Tituba sorcière… Noire de Salem (1986) de Marysé Condé. 

Los procesos de reescritura que dieron lugar a los textos revelan voces soslayadas por la historia y la literatura a partir del distanciamiento con los modelos femeninos imperantes y la (re)valorización del descubrimiento del cuerpo, las experiencias sexuales y sus prácticas.
Planeación de trayectorias por Fuzzy C-means para robots móviles
Authors: Useche-Murillo Paula Catalina , Pinzón-Arenas Javier Orlando , Jiménez-Moreno Robinson
Published: October 2021

En este artículo se presenta el diseño y ejecución de un algoritmo de planeación de trayectorias - en un ambiente de trabajo simulado - empleando el método de clustering por Fuzzy C-Means, para determinar el grado de pertenencia de cada punto del espacio a los obstáculos presentes en el área de desplazamiento de un robot móvil. Se desarrolló una herramienta en MATLAB® que permite ingresar la cantidad de objetos en dicha área, y así encontrar todos los posibles caminos que pasen en medio de ellos. El algoritmo logra identificar caminos para un ambiente con máximo 6 obstáculos, y le permite al usuario ingresar datos de control del algoritmo -como el coeficiente de partición del difuso (m) empleado para definir el ancho de cada camino según los requerimientos de la aplicación.
Microturbina operada con biogás generado por estiércol bovino
Authors: Rodríguez-Vargas Ángel David , Morales-García Laura Andrea , Rojas-Cubides Herbert Enrique
Published: October 2021

El artículo presenta los resultados del análisis del comportamiento de un sistema de generación distribuida compuesto por una microturbina operada con biogás, variando una carga característica de una zona no interconectada (ZNI). Para ello, se identifica una ZNI con alto potencial para el aprovechamiento eléctrico del biogás usando datos estadísticos de producción pecuaria y cobertura eléctrica; luego se estima la producción de biogás y su composición aplicando el modelo de digestión anaerobia (ADM1) implementado en MATLAB/Simulink®; posteriormente el sistema de generación distribuida es simulado usando el mismo entorno de programación. Se obtuvo que con el 1% del estiércol producido por la industria bovina de San Vicente del Caguán (66203,6 kg/día) sería posible generar 78868 kg de metano en 100 días; con esta cantidad de biocombustible se podría abastecer la demanda eléctrica promedio (29,97 kW) de la localidad San Juan de Caquetania (Colombia) durante 444 días usando una microturbina de 65 kW.
Análisis de distorsión armónica para controladores dimerizables en luminarias LED
Authors: Rincón-Triana César Andrés , Muñoz-Romero Javier Andrés , Noguera-Vega Luis Antonio
Published: October 2021

El propósito de esta investigación es identificar el comportamiento de los controladores de atenuación empleados para el funcionamiento de lámparas LED, dando cumplimiento a la norma IEC 61000, a través de análisis de distorsión armónica aplicada a controladores tipo TRIAC y PWM, comparando niveles de iluminación, THDi y corriente. Se demuestra que el controlador tipo TRIAC presenta niveles de distorsión armónica que no cumplen con los parámetros establecidos por la norma, en comparación con el controlador tipo PWM. Se evidencia la inconveniencia de implementar controladores tipo TRIAC por afectar la red eléctrica y los circuitos de donde se esté alimentando, a pesar que es el más accesible y económico del mercado.
Generación de condensado con celdas de Peltier
Authors: Moreno-Parra Yeison Dubiel , Pérez-Valdeblanquez Henry Erik , Garzón-González Enrique Yamid
Published: October 2021

En este artículo se detalla la construcción de un dispositivo que emplea las celdas de peltier como forma de obtener agua del medio ambiente mediante la condensación. Para lograrlo se optó por utilizar la tarjeta de desarrollo Freescale FRDM- KL25Z, que permite regular la tensión que llega a la celda mediante una modulación por PWM. Adicionalmente el microcontrolador se encarga de la lectura de variables medio ambientales como la humedad relativa, la temperatura ambiente y la temperatura sobre la cara fría de una Celda de Peltier. Para así poder variar el PWM manteniendo la temperatura de la cara fría de la celda por debajo del punto de roció obteniendo un condensado y un posible goteo de agua.
Struktur Sel Sekresi Daun Jeruk Kalamansi (Citrus microcarpa Bunge.) di Pulau Ambon
Authors: Horowidi Christina , Sinay Hermalina , Karuwal Ritha Lusian , Parinussa Lona
Published: October 2021

Perbedaan lokasi tumbuh dapat mengakibatkan perbedaan penampilan fenotipik tanaman yang dapat diamati secara morfologi dan anatomi seperti struktur anatomi sel sekretori. Tujuan penelitian ini adalah untuk mengetahui struktur sel sekretori daun jeruk kalamansi di pulau Ambon. Metode jelajah dilakukan pada 13 lokasi di Pulau Ambon untuk koleksi sampel, dan pada setiap lokasi diambil 3 tanaman sebagai 3 ulangan. Tiap tanaman diambil 5 daun pada setiap sisi pohon tanaman jeruk kalamansi dengan ukuran panjang 5-7 cm dan warna hijau tua. Pembuatan preparat mengikuti metode free hand section. Pengamatan menggunakan kamera Optilab pada mikroskop Olympus dengan perbesaran 400x. Pengukuran diameter sel menggunakan fitur measure pada software Image Ruster. Data kualitatif berupa struktur sel sekresi daun jeruk Kalamansi ditampilkan dalam bentuk gambar dan dideskripsikan sesuai hasil yang terlihat, sedangkan data hasil pengukuran diameter sel sekresi adalah rerata 3 ulangan dan ditampilkan sebagai mean ± standar deviasi (SD). Hasil penelitian menunjukkan adanya sel sekretori yang berjumlah satu sel. Struktur sel sekretori terdiri dari sel epitel, sel selubung, dan rongga sekretori. Bentuk sel sekresi ada yang bulat dan lonjong. Diameter rongga sekretori berkisar antara 106,08-167,60 µm.  Berdasarkan hasil penelitian, maka dapat disimpulkan bahwa sel sekresi pada daun jeruk kalamansi pada lokasi-lokasi berbeda di Pulau Ambon bervariasi baik bentuk maupun ukurannya. Differences in habitat can induce differences in the phenotypic appearance of plants that can be observed morphologically and anatomically such as the anatomical structure of secretory cells. The purpose of this study was to determine the structure of the secretory cells in the leaves of Calamansy citrus in Ambon island. Tracking method was done for sample collections, and at each location 3 plants were taken as replicates. Each plant was taken 5 leaves with a length of 5-7 cm and dark green color. Prior to be observed, the fresh sample was done with free-hand section method.   Microscopy observations were done by a light microscope at 400x magnification. Measurement of cell diameter was done by the measure feature in Image Ruster software.  Qualitative data such as secretory cell structures of Calamansy citrus leaves were shown in form of images and described according to the results, while the data of the measurement of secretory cell diameters is the average of 3 replications and was shown as mean ± standard deviation (SD).  The results showed the presence of secretory cells which amounted to one cell. The secretory cell structure is composed of epithelial cells, sheath cells, and secretory cavities. Cell shapes vary, including round and oval. The diameter of the secretory cell cavity ranges from 106.08-167.60 µm.
The Position of Local Self-Government in the Constitution of the Republic of Poland
Authors: Rabska Teresa
Published: October 2021

The paper is an English translation of Pozycja samorządu terytorialnego w konstytucji by Teresa Rabska published originally in Polish in the Journal of Law Economy and Sociology from 1995. The text is published as a part of a newly established section of the Adam Mickiewicz University devoted to the achievements of the late Professors of the Facultyof Law and Administration of the Adam Mickiewicz University, Poznań.