bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelaksanaan Peraturan Menteri Sosial
Authors: Nadiah Nadiah , Dalimunthe Dermina
Published: December 2023

Karang Taruna ia a community organization as a means of developing every member of the community that grows and develops on the basis of awareness and responsibility. However in Muaratais II Village Angkola Muaratais sub district, south Tapanuli Regency, the fuction of the youth Organization is still experiencing various promlems, one of wich is the potential of the younger generation and the community, the lack of attention from youth organization to providers of education and training for the community, and the lack community empowerment providers, especially the younger generation and the environment in a comprehensively integrated and directed manner and still experiencing many promlems due to thee lack of a sense of responsibility of society as individuals who have the potential and have a strong social sprit. From these problems, I want to know how the implementation of the Minister of Social Affairs Regulation Number 25 Year 2019 concerning the Function of Youth Organization in Muaratais District, Tapanuli Selatan Regency, what are the supporting and inhibiting factors, and how to riview Siyasah Fiqh on the implementation of the Minister of Social Affairs Regulation Number 25 of 2019 regarding the function youth organization in Muaratais II Village, Angkola Muaratais Sub-district, south Tapanuli Regency. The type of research used in this research I field research, using qualitative descriftive analysis methods, namely describing phenomena or events that data collection instruments used consisted of interviews, observations, and documentation. The result of this study are that the imolementation of the minister of social Affairs Regulation Number 25 of 2019 Article 6 paragraph (1) concerning yhe function of youth Organization in Muaratais
Persepsi KPU Terhadap Caleg Perempuan
Authors: HSB Siti Fatimah , Gunawan Syafri , Siregar Khoiruddin Manahan
Published: December 2023

This thesis is entitled the perception of the general election commission on the representation of women in the list of legislative candidates for the 2014-2019 period in the Mandailing Natal district (study of law number 7 of 2017 article 1 regarding elections. The general election commission has issued pkpu number 20 of 2018 regarding nominations for members of the DPR, the provincial dprd and district or city dprd and have been ratified by the ministry of law and human rights. But the birth of this pkpu did not go smoothly, especially regarding ex-corruptors not being allowed to nominate as members of the legislature. The involvement of women in politics from time to time continues to increase, one of the indicators is an increasing trend of women in the legislature, especially since the 1999 election until the 2009 election. However, in the 2014 election, women's representation has decreased and in law number 7 of 2017 concerning elections, it is necessary to have at least 30% of women's representation in the list of candidates to be legally registered. As a legislative candidate. This research is a type of qualitative research that emphasizes the analysis more on the inductive deductive inference process and on the analysis of the dynamics of the relationship between observed phenomena, using scientific logic. Qualitative research emphasizes efforts to answer research questions through a formal, argumentative way of thinking. This type of research is in the form of a field study. In this study the researcher found the results that the perception of the general election commission that the 30% quota of women's representation in legislative members in Mandailing Natal had not been fully implemented because of the individual factors of each woman and the lack of public trust in women due to negative views about gender
Pengangkatan Perangkat Desa Dalam Hukum Islam
Authors: Harianto Bambang , Siregar Fatahuddin Aziz , Harahap Ikhwanuddin
Published: December 2023

The purpose of this research is to know implementation of Law Number 6 of 2014 concerning the appointment of village officials in Gapuk Tua Village, Marancar District, South Tapanuli Regency in 2016, and a review of Islamic law on the implementation of Law Number 6 of 2014 concerning the appointment of village officials in Gapuk Tua Village. Marancar District, South Tapanuli Regency. The method used is a descriptive qualitative research method. The technique of collecting data in this research is through interviews, and observations. The results of this study concluded that the appointment of the Gapuk Tua Village Apparatus, Marancar District, South Tapanuli Regency as the implementation of Law Number 6 of 2014 concerning the appointment of village officials has not been fully implemented due to the lack of Village Apparatus requirements contained in the Act. The appointment of village officials through a process of direct appointment by the Village Head without an election process and deliberation with the residents and village officials. This is because there is an element of kinship between the village head and village officials. The review of Islamic law on the appointment of the Gapuk Tua village apparatus, Marancar District, South Tapanuli Regency has not fully implemented Islamic law, namely a leader must be fair and trustworthy.
Analisi Yuridis Akad Perjanjian Jual Beli Perumahan
Authors: Pane Abdul Hadi , Ahmatnijar Ahmatnijar
Published: December 2023

Population growth that is increasingly dense, especially in Indonesia, causes a large community need for a decent settlement. Because housing is a necessity that is very necessary for humans. This is what makes business actors take advantage of housing sales and purchase agreements that are detrimental to consumers whose economy is low and are pressed for housing needs that are livable. So it is feared that it can harm one of the parties who should run in harmony considering that the relationship between the two is a symbiotic mutualism. The problem in this research is the practice of the sale and purchase agreement of cash housing and credit PT. Nato Jaya Group Purwodadi Village, Padangsidimpuan District Batunadua and juridical analysis of the sale and purchase agreement that has been promised by PT. Nato Jaya Group, Purwodadi Village, Padangsidimpuan District, Batunadua.This type of research is field research, where researchers go directly to the field to examine a problem. Sources of data used are primary data and secondary data. Methods of data collection using direct observation, interviews, and documentation.The results of this study and the discussion explain the rights and obligations of the parties in the house sale and purchase agreement are reciprocal. This means that the obligation of the developer (PT. Nato Jaya Group) is the right of the home buyer/consumer. Likewise, the consumer's obligations become the rights of the developer. The developer's obligations include submitting ownership rights to the houses being traded. The obligation to surrender ownership rights includes all actions that are legally required to transfer ownership rights to the house being traded from the seller to the buyer. while the obligation of the buyer/consumer of the house unit is to pay the purchase price at the time and place as determined according to the agreement.
Interpretasi Karel A. Steenbrink terhadap Al-Masih
Authors: Hasibuan Rani
Published: December 2023

The Qur'an is the first source of Islamic law that was revealed to the prophet Muhammad SAW. However, the Qur'an is also not only the object of study by Muslim scientists, many non-Muslims also study the Qur'an such as Western scientists and they are said to be Orientalists. One of them is Karel A. Steenbrink who studies the relationship between Jesus AS and the God they believe in today, while Jesus AS is considered by Muslims only as an apostle and messenger of Allah SWT. In understanding this difference Karel refers to the verses of the Qur'an and gives a positive attitude and outlook, unlike other Christians. The formulation of the problem of the author is how Karel A. Steenbrink's attitude and views towards Isa Al-Masih and towards Isa Al-Masih's verses. The aim is to find out the attitudes and views of Karel A. Steenbrink towards Isa Al-Masih and the verses of Isa Al-Masih. The type of research used by the author is library research. The results of this study indicate that Karel A. Steenbrink does not blame and refute the Muslim understanding of Isa Al-Masih who is considered only a creature created by God who is made as a prophet as well as His apostle, while in the Christian understanding of the prophet Isa Al-Masih is a figure of God. known as Jesus Christ, the son of Mary. Karel also believes that the explanation of the verses about Isa Al-Masih has almost the same similarities, such as the process of the birth of Isa Al-Masih in the Qur'an and Christian books.
Perlindungan Hukum bagi Lanjut Usia Terlantar
Authors: Lestari Gita Ayu
Published: December 2023

The problem in this research is the extent to which the implementation of Law Number 11 Year 2009 Article 9 concerning Social Welfare Against Legal Protection for Abandoned Elderly in Public Services at the Titian Ridho Divine Nursing Home, Huta Holbung Village, Batang Angkola District, South Tapanuli Regency because of the process of organizing social welfare in protection. and the services provided by the Titian Ridho Divine Nursing Home Al Yusufiyah Foundation are not in accordance with Article 9 of Law Number 11 of 2009 concerning Social Welfare. The needs given to the elderly are not in accordance with those stipulated in Law Number 11 of 2009 namely the need for food and clothing, the need for peace, social needs and self-actualization needs. The purpose of this study is to describe and analyze the implementation of Law Number 11 of 2009 Article 9 concerning Social Welfare for Legal Protection for Abandoned Elderly in Public Services at the Titian Ridho Divine Nursing Home Al Yusufiyah Foundation, Huta Holbung Village, Batang Angkola District, South Tapanuli Regency. The formulation of the research problem is how to implement Law Number 11 of 2009 Article 9 concerning Social Welfare towards Legal Protection for Abandoned Elderly in Public Services at the Titian Ridho Divine Nursing Home, Al Yusufiyah Foundation, Huta Holbung Village, Batang Angkola District, South Tapanuli Regency and what are the factors? which affects the implementation of Law Number 11 of 2009 concerning Social Welfare at the Titian Ridho Divine Nursing Home Al Yusufiyah Foundation. The research method used in this study is a qualitative approach using descriptive methods, which describe phenomena that occur in the field. The data collection instruments used in this study consisted of interviews, observations, and documentation. The result of this research is the implementation of Law Number 11 Year 2009 Article 9 concerning Social Welfare Against Legal Protection for Abandoned Elderly in Public Services at the Titian Ridho Divine Nursing Home, Huta Holbung Village, Batang Angkola District, South Tapanuli Regency. The caretaker of the Titian Ridho Divine Nursing Home Al Yusufiyah Foundation is lacking in meeting the needs given because the orphanage only provides cottages and the activities provided are only recitation activities.
Motivation, Phrase, and Illusion Tutor on Instagram Accounts: Pragmatic Analysis Study
Authors: Sufyana Sufyana , El-Feyza Muhafizah , Hidayat M. Riyan , Imron Kristina , Amir Bakhrum
Published: December 2023

Lately, social media platforms, especially Instagram, are busy making memes as icons in every upload of message delivery. The creative design presented can attract the attention of netizens so that they can make the meme something that is favored by social media audiences. This article aims to describe the speech forms presented and uploaded by the Instagram account @motivasi.penghafal.al-quran and to describe how the function of the speech it conveys in the form of sentences designed into memes. The method used is descriptive-qualitative. The data collected was obtained from meme uploads about the motivation of memorizing the Qur'an on the Instagram account @motivasi.penghafal.al-quran. The utterances contained in each upload are analyzed using pragmatic theory. The results of this study indicate that the utterances uploaded to the Instagram account @motivasi.penghafal.al-quran are grouped based on their form and function, including; declaration, representation, expressive, directive, and commissive functions.
SCIENCE IN THE DEVELOPMENT OF ISLAMIC EDUCATION: Dialectics of Muslim Scientific Thought
Authors: Sumadi Eko
Published: December 2023

Islamic education is still understood traditionally as containing the sciences of tafaqquh fiddin. On the other hand, science is still considered a separate scientific discipline from Islamic Education. This study aims to explain and analyze the dialectics of scientists regarding Islamic Science and the urgency of science for the development of Islamic Education. This article is the result of a systematic literature review through the identification, evaluation and synthesis of the thoughts of Muslim scientists. This study concluded that science education is the peak achievement of Muslims' dialectic towards science. Science education is necessary for Islamic education, which will provide a way forward towards the revival of Islamic civilization—namely, science that uses metaphysics in an Islamic perspective to guide in formulating concepts about the universe. Finally, science education will only be realized if scientists and religionists have a harmonious relationship. So, it is necessary to create a dialogical, pluralist and democratic climate so science education can grow and run well.
Affirmative Policy A Necessity for Fulfilling the Political Rights of Persons with Disabilities
Authors: Pane Erina , Yanis Tryan Zaki Aulia
Published: December 2023

Persons with disabilities have political rights. The right to vote and the right to be elected in general elections. This article examines the political rights of persons with disabilities to be elected in general elections. This is important because the representation of persons with disabilities in the public sphere will voice the rights of persons with disabilities. The purpose of this research is to identify the factors that influence the lack of fulfillment of these political rights for persons with disabilities and to examine the fulfillment of their political rights through affirmative policies. The method used in this research is qualitative with a descriptive analytical approach. Primary data was obtained through in-depth interviews with several informants. Factors contributing to the lack of fulfillment of the political rights of persons with disabilities include education level, welfare, and lack of support from the environment and family. Affirmative policies can serve as an alternative to represent persons with disabilities in the public sphere.
Artificial intelligence applications in disease diagnosis and treatment: recent progress and outlook
Authors: Goswami Meenakshi , Sachan Pranjal , Goswami Kavita
Published: December 2023

The use of computers and other technologies to replicate human-like intelligent behaviour and critical thinking is known as artificial intelligence (AI).The development of AI-assisted applications and big data research has accelerated as a result of the rapid advancements in computing power, sensor technology, and platform accessibility that have accompanied advances in artificial intelligence. AI models and algorithms for planning and diagnosing endodontic procedures. The search engine evaluated information on artificial intelligence (AI) and its function in the field of endodontics, and it also incorporated databases like Google Scholar, PubMed, and Science Direct with the search criterion of original research articles published in English. Online appointment scheduling, online check-in at medical facilities, digitization of medical records, reminder calls for follow-up appointments and immunisation dates for children and pregnant women, as well as drug dosage algorithms and adverse effect warnings when prescribing multidrug combinations, are just a few of the tasks that already use artificial intelligence. Data from the review supported the conclusion that AI can play a significant role in endodontics, including the identification of apical lesions, classification and numbering of teeth, detection of dental caries, periodontitis, and periapical disease, diagnosis of various dental problems, aiding dentists in making referrals, and helping them develop more precise treatment plans for dental disorders. Although artificial intelligence (AI) has the potential to drastically alter how medicine is practised in ways that were previously unthinkable, many of its practical applications are still in their infancy and need additional research and development. Over the past ten years, artificial intelligence in ophthalmology has grown significantly and will continue to do so as imaging techniques and data processing algorithms improve.
Nephroprotective Effect of Vinpocetine against Vancomycin-induced Nephrotoxicity in Rats
Authors: Abdulameer Hassanen Ayad , Al-Zubaidy Adeeb Ahmed
Published: December 2023

Background:  The kidney is a vital organ for the body and is vulnerable to drug toxicity. For methicillin-resistant Staphylococcus aureus, vancomycin is the antibiotic of choice. It has been accompanied by nephrotoxicity, which restricts its use. Numerous studies have reported that nephrotoxicity was linked to oxidative stress and inflammatory response. Vinpocetine is a derivative of vincamine alkaloid used to treat some neurological disorders and has antioxidant and anti-inflammatory effects. 
The objective of the study: To evaluate the nephroprotective effect of vinpocetine against vancomycin-induced nephrotoxicity in rats.
Methods: Twenty-four albino male rats were randomly selected and divided into three groups (n = 8): (1) Normal group: apparently healthy rats. (2) Induction group: treated with vancomycin (200mg/kg) twice daily intraperitoneally for 14 days. (3) Vinpocetine group: As the group (2) and treated with vinpocetine (2.5mg/kg) twice daily orally, an hour before vancomycin administration.
Results: Vinpocetine group demonstrated a significant decrease in urea, creatinine, and cystatin C serum levels compared to the induction group. Also, it showed a significant reduction in the renal tissue level of malondialdehyde and a significant elevation in the renal tissue level of glutathione as compared to the induction group. Furthermore, the vinpocetine group showed a significant decrease in the renal tissue levels of tumour necrosis factor-alpha and neutrophil gelatinase-associated lipocalin. Histologically, all rats in vinpocetine group showed a significantly reduced level of renal tissue damage.
Conclusion: The present study shows that vinpocetine exhibited nephroprotective due to its antioxidant and anti-inflammatory effects.
Keywords: Nephrotoxicity, Oxidative stress, Vancomycin, Vinpocetine.
Evaluation of Serum Level and Interleukin-4 Receptor (rs1805010) Gene Polymorphism in a Sample of Osteoporosis Women
Authors: Hammadi Zainab Abdulrahman , Salih Maan Hasan , Rija Firas Faris
Published: December 2023

Background: Osteoporosis is characterized by subtle skeletal degeneration and bone loss, generally defined as a systemic metabolic disease. Interleukin-4 receptor (IL-4) R has been associated with osteoimmune, the relationship between the immune system and the skeleton (osteoimmune system) is studied in osteoimmunology.
Objectives: In this study, we aimed to investigate the serum level and polymorphisms to genotype IL-4R )rs1805010 ( and their effect on osteoporosis in Iraqi women.
Methods: ELISA was used to determine the serum level of the IL-4R and polymerase chain reaction (PCR) to genotype the IL4R gene in 90 Iraqi women (60 patients with osteoporosis and 30 control groups).
Results: The main findings on the IL-4R polymorphism (rs1805010) indicated that there was no association for the prediction of osteoporosis in Iraqi women. Whereas, there was a significant increase in serum levels of interleukin-4 receptor in women with osteoporosis compared to healthy women, (P = 0.018).
Conclusion: The study supposes that there is a link between the serum level of IL4R and how osteoporosis develops, but IL4R gene polymorphisms may not play a role in osteoporosis in women.
Keywords: Osteoporosis, rs1805010,  IL4R, Polymorphism.
In Vitro Study of the Effect of Vanillin Derivatives on Aryl Esterase, Troponine and Lipid Profile in Atherosclerosis Patients as Compared to Normal Subjects
Authors: Atallah Murooj Mousa , Khalid Fadhil Dawood , Sulaiman Yaser A.M.
Published: December 2023

The study describes the effect of vanillin derivative on the activity of aryl esterase in vitro. After that, the Estimated effectiveness of the enzyme aryl esterase, troponin T, and lipids. The research included the collection of 120 blood samples distributed to 60 blood samples of healthy people as a control group and 60 blood samples of patients with atherosclerosis who were diagnosed under the supervision of specialized doctors at Salah Eddin General Hospital / Catheterization Unit.
Results showed that the vanillin derivative has an invigorating effect on the activity of aryl esterase, and that the degree of enzyme activation increases with the increase in the concentration of the derivative, while there was lower with a probability level (P≤ 0.0006) in the activity of aryl esterase from the serum of patients with atherosclerosis in addition, a significant increase at the probability level ( P ≤ 0.001) in the level of total cholesterol, triglycerides, LDL-C and VLDL-C, while there was decrease at the probability level (P ≤ 0.0004) in the level of  HDL-C.
Keywords: Aryl esterase, Vanillin derivative, Lipids, Atherosclerosis.
The Cornerstone of the Ecumene: on the question of the medieval Church center of Zichia
Authors: Kostanenko Leonid Andreevich
Published: December 2023

The subject of the study is the history of Christianization of the part of the Caucasian Black Sea region located in the South of Russia and the adjacent territory. Since its inception, in the 1st century AD, Christianity has formed a complex structured organization that gradually spread its influence over the territory of the Roman Empire and a number of other states. In the Western Caucasus, the presence of a church organization has been recorded since the sixth century, however, a large amount of archaeological data indicates that the first Christian communities in Southern Russia arose much earlier. Special attention is paid to the consideration of issues related to the formation and development of the Christian mission on the Black Sea coast of the Western Caucasus in the medieval period. The author examines the stages of Christianization of the autochthonous peoples of the region, paying special attention to the complex aspects of their ethnogenesis and political development, as well as the evolution of geographical representations of this territory in the consciousness of the civilized world represented by the Byzantine Empire. The importance of the problem of localization of the largest religious center – Nikopsia of Zikhi leads to the need for a thorough analysis of the available narrative sources, the conclusions of which are comprehensively included in the results of this study and are additionally illustrated in the table. The main result of this study is the identification of an obvious contradiction in approaches to the localization of Zikhian Nicopsia. Despite the fact that a fairly large number of researchers have addressed this problem, it should be noted that this problem has not yet been definitively resolved. The main premise characterizing the approach of most researchers who have addressed this topic is the idea of the uniqueness of the oikonym "Nikopsia" for the Caucasian Black Sea region. This idea gave rise to numerous versions of the localization of the famous, according to a number of medieval sources, Nicopsia of Zikhi. At the same time, most medieval literary monuments of Caucasian origin are united in the issue of localization of this, one of the oldest, Christian centers of the Western Caucasus. Nikopsia of Zikhi, which changed its name in the early tenth century, later became known as Anakopia.
Art Nouveau in the architecture of South-coast villas and palaces as a contribution of outstanding personalities of their owners and architects to the cultural landscape of Crimea
Authors: Kotliar Elena Romanovna , Khlevnoi Vladimir Aleksandrovich
Published: December 2023

The Art Nouveau style in architecture of the late XIX-the first third of the twentieth century was distinguished by the synthesis of all previous styles and the free variability of the composition of both the main architectural volumes and their decor. Depending on the predominance of a particular style in a particular building, it is classified as a sub-style, for example, Neo-Gothic, Neo-Baroque, Neo-Renaissance, Neo-Russe, etc. A characteristic feature of modernity is also the use of various ethnic elements by architects. The subject of the article is the cultural characteristics of villas and palaces on the Southern coast of Crimea and the individual character reflected in them by architects in accordance with the requirements of customers, their national and professional affiliation, interests and hobbies. A special contribution of the authors is the analysis of the examples of architecture and its decoration, not abstractly, but in close connection with the personality of their owners and customers. The article uses the methods of historicism and the comparative method in the analysis of the belonging of an architectural object to a particular style; methods of analysis and synthesis in the characteristics of styles of both individual parts of architectural monuments and the entire building as a whole. The scientific novelty of the study lies in the fact that for the first time the authors described the villas and palaces of the Southern coast of Crimea not only from a historical, architectural and historical-art historical point of view, but from the point of view of matching the styles of buildings to the individual characteristics of the personalities of their owners. Conclusions. 1. The Art Nouveau style spread in Western and Eastern Europe, including Crimea, from the end of the XIX century, and existed on the peninsula until the 1930s. The elegant character of country villas and palaces, mostly white, was especially relevant in Crimea, contrasting with the blue sky and sea and bright vegetation, creating a typical southern the color of the resort area. 2. The cultural landscape of Crimea is made up of a diverse variety of ethnic cultures, the heritage of state entities, as well as outstanding personalities who have contributed to it. In this sense, the unique buildings and their connection with the personalities of their owners represent one of the characteristic features of the historical and cultural landscape of Crimea.
Pelatihan Elektronika Dasar untuk Guru dan Siswa Kelas VIII SMP di Cilincing Jakarta Utara
Authors: Rippun G. Manalu Ferry , Octaviani Sandra , Octavianus Bachri Karel , Surya Permana Rizky , Olivia Sereati Catherine
Published: December 2023

Pada Juni 2019, prodi Teknik Elektro Fakultas Teknik Unika Atma Jaya telah menyelenggarakan program pengabdian kepada masyarakat dengan tema memberi pembekalan tangan keterampilan dasar elektronika kepada SMP Kristen Harapan bagi Bangsa di Cilincing Jakarta Utara. Program ini mendapatkan tanggapan yang positif dari guru dan siswa. Berdasarkan hasil evaluasi kegiatan sebelumnya, seluruh siswa (100%) ingin kegiatan ini diadakan lagi dengan materi lanjutan. Pada kegiatan sebelumnya guru belum dilibatkan dalam proses, sehingga keberlanjutan program tidak dapat dilaksanakan secara rutin di sekolah. Oleh karena itu, pada program ini, selain melanjutkan pelatihan kepada siswa kelas VIII, guru juga dilibatkan dalam pembekalan untuk menyelenggarakan program ekstrakurikuler mengenai dasar elektronika selanjutnya. Pelatihan elektronika yang akan dilaksanakan pada pengabdian masyarakat ini difokuskan untuk siswa kelas VIII dan meliputi materi membuat PCB, pengenalan project board, pengenalan komponen elektronika dan fungsi-fungsinya. Pada tahapan ini peserta sudah mampu membuat rangkaian sederhana, membuat prototipe rangkaian elektronika menggunakan project board dan diimplementasikan dalam electronic kit. Kegiatan pengabdian ini diharapkan dapat melengkapi keterampilan siswa dan guru dalam bidang elektronika sehingga siap dalam menghadapi kemajuan teknologi, khususnya di bidang Teknik Elektro
Program Kewirausahaan untuk Membiayai Kegiatan Sosial di Pantai Asuhan Hati Suci: AKEGISO Aksi Kegiatan Sosial
Authors: Widiasari Natalia , Intanya Variantika , Ardila Preti , Benaya Manuel , Michelle Michelle , Sunita Sunita
Published: December 2023

Adanya kesadaran pola konsumsi berlebihan terkait produk fashion di kalangan anak muda. Dinamika dunia modern mendorong pakaian tidak lagi hanya kebutuhan yang memenuhi fungsinya, tetapi juga memenuhi kebutuhan sosialisasi dan dekoratif. Hal ini membuat anak muda zaman ini cenderung membeli pakaian berdasarkan selera dan pergantian gaya yang berubah-ubah dalam tempo singkat. Kecenderungan tersebut membuat pakaian menumpuk melebihi kapasitas penyimpanan. Banyak di antara pakaian tersebut hanya dipakai satu atau dua kali. Kesadaran hal ini mendorong Tim untuk melakukan karya sosial bermodalkan pakaian tersebut. Pakaian tersebut dibagi ke dalam dua kategori: yang dapat didonasikan (memenuhi selera umum dan sopan digunakan dalam situasi apa pun, dan yang kedua tidak dapat didonasikan (karena kurang sopan potongannya) sehingga akan dijual melalui “Thrift Store Online Akegiso”. Kegiatan ini terdiri atas tiga kegiatan utama. Pertama, terkait pengelolaan pakaian bekas; kedua, kegiatan mengumpulkan uang atau mencari donatur; ketiga, melaksanakan kegiatan sosial di panti asuhan. Pola utama yang dimunculkan ialah bagaimana kegiatan sosial dapat didanai dengan kegiatan bisnis. Memang ada pengumpulan dana tunai untuk menutup kekurangan. Meskipun demikian jumlah pendanaan tetap didominasi dari hasil penjualan pakaian bekas.
Edukasi Pemberian ASI Eksklusif di Cisalak Pasar
Authors: Harumsari Novita , Malkan Bakhrul Ilmi Ibnu , Intania Sofianita Nur , Ayu Arini Firlia
Published: December 2023

Air Susu Ibu (ASI) eksklusif adalah ASI yang diberikan kepada bayi sejak dilahirkan sampai bayi berusia 6 bulan tanpa menambahkan dan/atau mengganti dengan makanan atau minuman lain (kecuali obat dan vitamin). Cakupan pemberian ASI eksklusif tahun 2021 di Depok sebesar 73,61% dan di Puskesmas Cisalak Pasar sebesar 75,51%. Intervensi yang dapat dilakukan dalam meningkatkan cakupan adalah penyuluhan berupa pemberian edukasi terkait pemberian ASI eksklusif. Kegiatan ini bertujuan untuk memberikan edukasi pemberian ASI eksklusif pada bayi 0-6 bulan di wilayah kerja UPTD Puskesmas Cisalak Pasar. Metode yang digunakan adalah penyuluhan secara door-to-door menggunakan media booklet dan brosur kepada pengasuh bayi 0-6 bulan di wilayah kerja Puskesmas Cisalak Pasar. Analisis statistik yang digunakan adalah uji wilcoxon. Hasil yang didapatkan adalah terdapat perbedaan antara nilai pretest dan postes setelah diberikan penyuluhan pemberian ASI eksklusif, dengan nilai p-value = 0,006. Simpulan yang dapat diambil ialah terdapat pengaruh kegiatan intervensi berupa penyuluhan terkait pemberian ASI eksklusif di wilayah kerja UPTD Puskesmas Cisalak Pasar.
Pelatihan Pengembangan Bisnis Mahasiswa Asing di Tiongkok
Authors: Hariyanti Nunik , Pranolo Andri , Salim Agus , Fadillah Dani , Khotimah Husnul , Firdaus Nalendra
Published: December 2023

Tiongkok merupakan salah satu pusat negara tujuan untuk melanjutkan studi. Salah satu kota tujuan studi adalah kota Nanjing. Bisnis ekspor-impor merupakan peluang yang dapat dilakukan oleh para mahasiswa untuk meningkatkan penghasilan tambahan bagi mahasiswa. Selama ini mahasiswa hanya berbisnis dalam skala kecil, tetapi belum menjangkau pasar antarnegara. Tidak jarang mahasiswa kesulitan menemukan cara untuk memulai bisnis ekspor-impor ini. Tujuan pengabdian ini adalah memberikan pelatihan pengembangan bisnis ekspor-impor bagi mahasiswa asing di Tiongkok melalui kegiatan pelatihan penentuan produk ekspor-impor, pelatihan mempersiapkan dokumen ekspor-impor, dan pengenalan membangun bisnis ekspor-impor. Kegiatan ini dilaksanakan secara luring di Tiongkok dengan metode presentasi, diskusi, dan pendampingan yang dilakukan sejak Juli hingga September 2023. Pelatihan meliputi kegiatan penentuan produk ekspor-impor, pelatihan mengenal dokumen ekspor-impor dan pembuatan perusahaan ekspor-impor. Hasil pretest dan post-test kegiatan ini menunjukkan bahwa pengetahuan peserta meningkat dari rata-rata 7,2 menjadi 9,7 terkait dengan ekspor-impor.
GENETICAL ANALYSIS OF INFLUENZA VIRUS AND SARS-COV-2 FROM COINFECTION CASES IN RUSSIAN FEDERATION IN EPIDEMIOLOGICAL SEASON 2022–2023
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Boldyrev N.D. , Kolosova N.P. , Danilenko A.V. , Svyatchenko S.V. , Onkhonova G.S. , Starchevskaya M.E. , Marchenko V.Yu. , Ryzhikov A.B.
Published: December 2023

In the pandemic context of a novel coronavirus infection SARS-CoV-2, after a year break, the seasonal circulation of influenza continues. With such cocirculation, there is a risk of a mixed infection, which can lead to a more severe course of the disease. Monitoring of respiratory infections in the epidemic season 2022-2023 showed the presence of mixed influenza viruses and SARS-CoV-2 infection cases. Most specimens were received from people at risk group. Among detected cases of coinfection, a higher incidence of cases with a fatal outcome was detected than among detected cases of influenza and COVID-19 separately. Cases of coinfection require special attention in epidemiological monitoring, diagnosis and treatment. Identified cases of coinfection are associated with higher severity and mortality than cases of influenza and COVID19 separately. Such cases require special attention in epidemiological monitoring, diagnosis and treatment.
STUDY OF FALSE POSITIVE AGGLUTINATION DUE TO NEURAMINIDASE ACTIVITY IN MODERN INFLUENZA A (H3N2) VIRUSES
Authors:   Smorodintsev Research Institute of Influenza, Saint Petersburg, Boyarintseva A.Yu. , Petrova P.A. , Konovalova N.I. , Danilenko D.M. , Eropkin M.Yu.
Published: December 2023

In the result of evolution, neuraminidase (NA) has acquired the ability to bind to guinea pig erythrocytes and give false agglutination, which makes it difficult to interpret the results of hemagglutination test and HI-test. From 2013 to 2023 more than 700 A(H3N2) strains have been studied. Viruses from 2013 to 2017 showed a trend towards a decrease in hemagglutination titers with the addition of an inhibitor NA by 2, 8 and 16 times. False agglutination is not observed in isolates 2018-2023 and the HA titer stays the same.
THE INFLUENCE OF EXOSOMES SECRETED BY BOTH INFLUENZA VIRUS-INFECTED AND NON-INFECTED CELLS ON VIRUS REPLICATION
Authors:   Smorodintsev Research Institute of Influenza, Saint Petersburg, Zabrodskaya Y.A. , Gavrilova N.V. , Plotnikova M.A. , Lozhkov A.A. ,   Peter the Great Saint Petersburg Polytechnical University
Published: December 2023

Exosomes secreted by both influenza virus infected (EV) and non-infected (E) cells were isolated. It was demonstrated that EVs could suppress the immune response of cells. When cells were infected with the influenza virus in the presence of either E or EV, it was observed that E had a protective effect, reducing virus replication. Conversely, EV had a proviral effect, meaning it enhanced virus replication.
A STUDY OF CLASS M ANTIBODY TITER IN RECOVERED COVID-19 PATIENTS TO THE RECEPTOR-BINDING DOMAIN OF THE SARS-COV-2 SPIKE PROTEIN
Authors:   Altai State University, Barnaul, Zyabliczkaya E.O. , Shcherbakov D.N. , Elchaninova S.A. , Kolosova E.A. ,   State Research Center of Virology and Biotechnology VECTOR, Koltsovo,   Altai State Medical University, Barnaul
Published: December 2023

Despite the cancellation of the COVID-19 pandemic status, the question of the dynamics of specific antibodies to the new coronavirus is still relevant. The aim of this study is to assess the level of class M antibodies to the receptor-binding domain of the SARS-CoV-2 spike protein in recovered COVID-19 patients and to search for its relationship with such indicators and characteristics as the positivity coefficient, sex, age, severity and duration of the period after the disease.
RECOMBINANT VIRUS EXHIBITING GP38 OF CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Ivkina D.I. , Imatdinov A.R. , Dubrovskaya E.V. , Imatdinov I.R. ,   Novosibirsk State University
Published: December 2023

Crimean-Congo hemorrhagic fever (CCHF) is a widespread arbovirus disease with a mortality rate of up to 40 % in humans. Despite the severity of the disease and the geographic distribution of CCHF, no vaccine or therapeutic agents are currently registered. The paper presents data on a recombinant rhabdovirus expressing a modified glycoprotein GPC of the CCHF virus, an isolate epidemiologically relevant for the Russian Federation.
COMPARISON OF ONCOLYTIC EFFECT OF MYXOMA VIRUS, VESICULAR STOMATITIS VIRUS AND NEWCASTLE DISEASE VIRUS
Authors:   I.M. Sechenov First Moscow State Medical University, Isaeva A.S. , Volodina S.I. , Porozova N.O. , Idota E.E. , Babaeva G. , Pokrovsky V.S. , Malogolovkin A.S. ,   Moscow Institute of Physics and Technology, Dolgoprudny,   Peoples’ Friendship University of Russia (RUDN University), Moscow,   N.N. Blokhin Cancer Research Center, Moscow,   Sirius University of Science and Technology, Sochi
Published: December 2023

Compared to conventional methods for tumor treatment, oncolytic viruses have a number of advantages: tropism to tumors of various origins, lytic and immunostimulating effect. In our study, we compared the oncolytic effect of myxoma viruses, vesicular stomatitis and Newcastle disease using in vitro and in vivo cancer models.
COMPARATIVE ANALYSIS OF THE BIOLOGICAL PROPERTIES OF VIRULENT AND ATTENUATED STRAINS OF AFRICAN SWINE FEVER VIRUS
Authors:   Federal Research Center for Virology and Microbiology, Volginsky, Koltsov A.Yu. , Kholod N.S. , Krutko S.A. , Belov S.V. , Korotin A.V. , Rudakova S.V. , Sukher M.M. , Koltsova G.S.
Published: December 2023

African swine fever is a contagious disease of pigs caused by the ASF virus. The main problem in the field of ASF control is the lack of vaccines. Attempts to obtain vaccines by attenuating the ASFV on cultured cell lines led to the production of attenuated viruses, some of which provided protection against infection with a homologous virus. Here we report on the biological and genomic features of the attenuated Congo-a virus compared to its virulent homologue Congo-v.
LOW-DOSE SMALLPOX VACCINATION IN A MOUSE MODEL
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Konyakhina Yu.V. , Sergeev A.A. , Titova K.A. , Pyankov S.A. , Yakubitskiy S.N. , Shchelkunov S.N.
Published: December 2023

Vaccinia virus (VACV) strains caused a more pronounced production of antibodies with intradermal (i.d.) injection compared to scarification (s.s.) inoculation. To test for developed protective immunity at 62 day post vaccination (dpv), mice were intranasally infected with a cowpox virus. The results showed that i.d. injection provided the development of protective immunity in mice to a much greater extent compared to s.s. inoculation with VACV strains.
RESISTANCE OF VIRAL RNA STRUCTURES OF FLAVI-LIKE VIRUSES WITH SEGMENTED GENOME TO XRN1 EXONUCLEASE
Authors:   Lomonosov Moscow State University, Okhezin E.V. , Litov A.G. , Karganova G.G. ,   Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products RAS, Moscow
Published: December 2023

Subgenomic orthoflaviviral RNA is a product of incomplete degradation of genomic orthoflavivirus RNA by 5’-3’ cell exoribonuclease XRN1. Resistance to complete hydrolysis is determined by conserved secondary structure motifs localized at the 3’ end of the genomic RNA. In this research, we study the exonuclease resistance of genomic RNA segments Alonghan virus in an in vitro assay
VIRUSES OF GRANULOSIS OF THE APPLE MOTH FROM THE BIORESOURCE COLLECTION OF THE FSBSI FRCBPP WITH INSECTICIDAL ACTIVITY
Authors:   Federal Research Center of Biological Plant Protection, Krasnodar, Tsygichko A.A.
Published: December 2023

The entomopathogenic activity of the 18 apple codling moth granulosis virus strains from the bioresource collection of the Federal Research Center of Biological Plant Protection «State Collection of Entomoacariphages and Microorganisms» against Cydia pomonella caterpillars was assessed in vitro. The most effective strains of the apple moth granulosa virus (BZR GV 11 and BZR GV L-3) were revealed, the level of entomopathogenic activity of which was 90,3-100 % on the 10th day of the experiment.
HIGH THROUGHPUT DNA SEQUENCING OF HEPATITIS B VIRUS
Authors:   Central Research Institute of Epidemiology, Moscow, Chanyshev M.D. , Vlasenko N.V. , Kotov I.A. , Khafizov K.F. , Akimkin V.G. ,   Moscow Institute of Physics and Technology, Dolgoprudny
Published: December 2023

It was shown that Hepatitis B Virus (HBV) genotype and individual mutations influence the course of the disease. There is a need for a simple and reliable method for sequencing the entire genome of hepatitis B virus. We have developed an NGS amplification panel for hepatitis B virus genome sequencing. The panel was validated using Sanger sequencing. More than 300 HBV samples were sequenced and genotypes and mutations described in the literature were identified.
RETROSPECTIVE DETECTION OF CASES OF MONKEYPOX VIRUS DISEASE BY IMMUNODIAGNOSIS IN THE REPUBLIC OF GUINEA
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Shulgina I.S. , Pyankov S.A. , Tyurtin V.Yu. , Pyankov O.V.
Published: December 2023

The thesis present the results of a study conducted in the Republic of Guinea. The paper used a recombinant protein unique to the MPXV. Specific IgG to MPXV antibodies serum found in blood serum samples. Conclusions have been drawn about the possible expansion of work and improvement of diagnostic tools in West Africa.
Status de vitamina D: estudo comparativo entre indivíduos com doenças autoimunes e saudáveis
Authors: Silva Aline Lima da , De Andrade Clara Maria Trevisani , Corrêa Gabriel Bonato , Paiva Géssica Campos , Lopes Giovanna Amaral , Lima Josânia da Silva , Calil Raquel Andrade Soares , Dias Anna Marcella Neves , Mendes Nathália Barbosa do Espírito Santo , Franco Danielle Cristina Zimmermann
Published: December 2023

Objetivo: Comparar os valores de Vitamina D (VD) entre pacientes com e sem o diagnóstico de doença autoimune, caracterizando-os quanto ao sexo, idade, tipo de enfermidade e nível desta vitamina. Métodos: Estudo transversal utilizando dados coletados entre janeiro a agosto de 2019, por meio de prontuários de pacientes acima de 18 anos, de ambos os sexos, que realizaram dosagem sérica de calcidiol (25(OH)D) e classificados com ou sem diagnóstico de doença autoimune. Os dados foram analisados por meio de estatística descritiva, teste t, ANOVA e qui quadrado (p<0,005). Resultados: Em ambos os grupos predominaram pacientes com valores de VD entre 20 e 60 ng/ml e não houve distribuição discrepante entre os indivíduos dos grupos pelos intervalos propostos para avaliação da vitamina. Com relação ao sexo e faixa etária, houve predomínio do sexo feminino (90%) e a mediana da idade foi de 57 anos. Observou-se que, a artrite reumatoide foi a doença autoimune mais frequente em indivíduos com valores inconformes de vitamina D, seguido de lúpus eritematoso e esclerose múltipla. Conclusão: A prevalência de valores de VD inferiores a recomendação para pacientes com doenças autoimunes encontrada nesse estudo ressalta a necessidade de monitoramento assíduo e suplementação adequada para este grupo.
Doença de chagas e envelhecimento: avaliação cognitiva e funcional em adultos com doença de chagas
Authors: Santiago Caroline Nunes , Bueno Giovanna Hass , Almeida Eros Antonio de , Martins Luiz Claudio
Published: December 2023

Objetivo: Investigar as repercussões funcionais e cognitivas da Doença de Chagas e sua relação com características epidemiológicas. Métodos: Estudo epidemiológico analítico transversal quantitativo realizado com adultos em acompanhamento em ambulatório especializado. Foram utilizadas as escalas de Lawton e Katz para avaliar funcionalidade, a Escala de Depressão Geriátrica foi utilizada para triagem de sintomas depressivos. Para avaliar as condições cognitivas, foram usadas as escalas de Mini-Exame do Estado Mental (MEEM) e uma bateria breve de triagem cognitiva. Resultados: O estudo foi composto por 60 pacientes com DC, sendo o grupo dividido em: cardíaco, digestivo, indeterminado. Pacientes do grupo cardíaco (p = 0,043) e indeterminado (p = 0,018) apresentaram maior probabilidade de apresentar sintomas depressivos. Os grupos "cardíaco" (p = 0,044) e "digestivo" (p = 0,028) apresentaram pior desempenho nos testes cognitivos. O grupo cardíaco também apresentou pior desempenho para o teste de fluência verbal (p = 0,007) e para o teste do relógio (p = 0,001). Conclusão: Os resultados indicam a presença de associação entre as manifestações clínicas da doença e piores resultados nos testes cognitivos, também foi encontrada em pacientes com a doença propensão para sintomas depressivos. Não houve associação entre a doença e perda de funcionalidade.
Granulomatous cheilitis and lingua plicata – An incomplete triad of Melkersson–Rosenthal syndrome
Authors: Vijay V. , Arumugam Iswarya , David Brinda , Singh Yogindher
Published: December 2023

Granulomatous cheilitis is a rare granulomatous inflammatory disorder characterized by chronic swelling of the lips. It is an oligosymptomatic form or an incomplete form of Melkersson–Rosenthal syndrome, which comprises recurrent orofacial edema, facial nerve palsy, and fissured tongue. Here, we present a case of a 45-year-old female with persistent upper lip swelling for three months.
Does the size of unifocal papillary thyroid carcinomas affect the status of the cervical lymph nodes?
Authors: Rezkallah Emad Mofid Nassif , Mahmoud Yousif , Mekhaeil Kamel , Hanna Ragai Sobhi
Published: December 2023

Objectives:

Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy in humans. Cervical lymph node (LN) involvement is one of the major prognostic factors in disease recurrence and morbidity. Despite central lymph node dissection (CLND) is recommended in the case of involved LNs, prophylactic neck dissection is still controversial due to the potential complications associated with this procedure. The aim of the current review is to assess the correlation between the sizes of unifocal PTC with cervical LN involvement, which could help to choose the best treatment plan for patients with PTC.

Materials and Methods:

We performed a retrospective review for all patients who had unifocal PTC in our department from 2013 to 2019 with a minimum of 3 years of follow-up. SPSS software was used to calculate this correlation.

Results:

Fifty-nine patients (38 females and 21 males) were included in our study with an average age of 45.4 ± 17 years of age. Out of 17 patients (28.8%) with microcarcinomas, six of them (10.2%) had cervical LN involvement, whereas of the 42 patients (71.2%) with macrocarcinomas, 17 of them (28.8%) had cervical LN metastasis. The correlation between the tumor size and the number of metastatic LNs in our study was weakly positive (r = 0.332, P < 0.05).

Conclusion:

The decision regarding CLND should be selected on an individual base as even small micro PTC could metastasize to the local LNs.