bluuebunny/crossref_metadata_2025 huggingface dataset:
OBJECT-ORIENTED IMPLEMENTATION OF A WEB APPLICATION FOR TRAFFIC SIMULATION
Authors:   University of Customs and Finance, Dnipro, Ulianovska Yu.V. , Firsov A.D. ,   University of Customs and Finance, Dnipro, Mormul M.F. ,   University of Customs and Finance, Dnipro, Pikulin D.O. ,   University of Customs and Finance, Dnipro
Published: October 2023

Work is devoted the development of web-appendix for the imitation design of municipal travelling motion on crossing. As on this time a transport system dissatisfies on 100% of demand through the moral ramshackleness and existence of many factors that influence on her, and that it is difficult constantly to take into account a man, an actual task is automation of process of design of transport streams by software development on the basis of modern web technologies. The classes of primary and necessary data are in-process analyzed, boolean variables, classes of necessary functions. The program is worked out in programming of JavaScript language, experimental calculations are done. In the total it is worked out web-appendix, that simplifies research of transport areas due to an imitation design, that allows to perfect monitoring of the travelling crossing and promote them carrying capacity. web-appendix has a simple intuitively-clear interface and does verification of correctness of the entered data, that allows to work with him to the people with minimum skills and without the special knowledge. Software was worked out adaptive, that allows to work with him from any device that has the set web-browser. Due to development of one main file in programming of JavaScript language, him it easily to integrate and use in the prepared decisions on different languages both in web-additions and in programmatic provided, for example in C# or C++. It allows to inculcate the use of programmatic means with the minimum charges of money and time. Due to application of the worked out system of imitation design of travelling motion on crossing efficiency of functioning of the managed crossing will considerably increase with a traffic-light type adjusting.
Comment les organisations pirates construisent-elles leur légitimité ? Le cas de la start-up Heetch
Authors: Massey Maxime , Bureau Sylvain , Naccache Philippe
Published: October 2023

Les organisations pirates développent des activités innovantes qui sont jugées illégales et illégitimes par l'État et les acteurs établis. Dans ce contexte, comment répondent-elles aux pressions institutionnelles qui pèsent sur elles pour construire leur légitimité ? Les auteurs explorent cette question en étudiant le cas de la start-up Heetch, une plateforme numérique de transport considérée comme pirate à ses débuts. Ils révèlent une trajectoire de légitimation en trois phases - pragmatisme clandestin, activisme subversif, radicalisme tempéré - tout en éclairant l'intérêt de la piraterie comme positionnement stratégique pour amorcer la croissance d'une organisation. Cet article offre ainsi une meilleure compréhension du processus de légitimation des organisations pirates.
Thermal protection improvement of building envelope near external corner (Tomsk)
Authors: Ivanova E. A. , Penyavskii V. V.
Published: October 2023

The problem of energy saving is relevant nowadays. Great attention is especially paid to improving the energy efficiency of different building envelopes, since the heat consumption is a significant part of total costs for utility needs.

   Purpose: The aim of the paper is to study the state of the building envelopes nearby the outer corner.

   Research findings: Methods of reduction of the negative impact of the thermal bypass nearby the corner manifest themselves in condensation, mold, and subsequently lead to the envelope destruction. The use of insulated bevel edge leads to better results than that without insulation. But the minimum dew point temperature remains at corners and does not exceed 13.5 °C. Only in this case, the minimum dew point temperature moves to bevel edges.

   Value: The thermal bypass (outer corner) effect on the temperature field of its inner surface is studied. Three wall thicknesses are investigated: 510, 640, and 770 mm. It is shown that in all cases the corner temperature decreases below the dew point temperature.
Historical settlements on territories of Kazan and Kama agglomerations (Kazan)
Authors: Khakimova T. S.
Published: October 2023

Due to the growing interest in the country's resources, including territories, it is worth paying attention to historical settlements, i. e., potential tourist, recreational, cultural objects, integral components of regional, group and district settlement systems, territories with cultural heritage objects. The article considers historical settlements in Kazan and Kama agglomerations of the Re-public of Tatarstan.

   The purpose of the study is to determine the historical settlement position on the territory of these agglomerations.

   Research is based on practice, data from the state statistics service, cartographic materials, documents on territorial planning of the region, municipalities as part of agglomerations, field studies. Methods of analysis, historical and archival documents, cartographic analysis, field studies are applied. The functioning of historical settlements on the territory of Kazan and Kama agglomerations is investigated. The article defines problems and tasks of including historical settlements in the functional framework of the territory.
Spectral pyrometry of non-metallic materials at plasma heating, melting and cooling (Tomsk)
Authors: Shekhovtsov V. V.
Published: October 2023

Spectral pyrometry of non-metallic materials under plasma heating, melting and cooling is used in nanotechnology, medicine, energy, metallurgy and other industries, where accurate temperature control is required during processing various materials.

   Purpose: The aim of this work is to create new spectral pyrometry technique for temperature measurement in difficult conditions of material processing and synthesis, such as plasma heating, melting and cooling of non-metallic materials.

   Methodology/approach: Small-sized spectrometers for diagnostics of heating, melting and cooling of the quartz target using the plasma jet. HPCS300 Mini Spectrometer with the wavelength range of 380 to 780 nm is used to determine the color temperature of the reference radiation source and for fiber optic calibration. The STS-VIS Microspectrometer based on a 1024×1 element CCD photodetector array with the wavelength range of 350 to 800 nm is used to record the emission spectrum of the object.

   Research findings: Improvement of production processes, fuel and material cost reduction, increase in the efficiency of plants and equipment, reliability and quality improvement of the final product.

   Value: During the plasma jet and quartz target interaction, three stages are observed: surface deformation, stable temperature of heating, and cooling of the condensed material with phase-transition points of liquid–pyroplastic–solid states.
Model of Building Maintenance Planning Using The Building Information Modeling (BIM)
Authors: Soetjipto Jojok Widodo , Zarkasi Ilham Kahfi , Trisiana Anita
Published: October 2023

Building maintenance is essential for the operation of the building to maintain the reliability and performance of the building to match its economic age. There are many buildings whose maintenance is inferior from a technical, administrative, and budgetary perspective, so an appropriate maintenance design model is needed according to the operational needs of the building. On the other hand, the development of digital information technology is getting faster and more widely used. One is Building Information Modeling (BIM), where the entire activity process works in collaboration and integration. Therefore, this study aims to develop a proper building maintenance design model using BIM. The method used is to apply building maintenance standards in Indonesia (Public  Works  Ministrial  Regulation No 24/PRT/M/2008) in BIM supporting applications, namely Autodesk Revit (for visualizing 3D buildings) and Autodesk BIM 360 Ops (for maintenance management), as a case study using the Maintenance Management Design of Walini Station which is one of the Jakarta-Bandung fast train stations with very modern, complex and complicated building components. The maintenance design model is carried out through the following stages: (i) building modeling using Autodesk Revit based on shop drawings in 3D and can be applied to 4D and 5D needs; (ii) export Autodesk Revit results to the Autodesk BIM 360 Ops application because this application can store a database of all building operations; and (iii) conducting a maintenance design simulation using the Autodesk BIM 360 Ops application. The study results show that BIM technology can be used as a detailed, accurate, effective, efficient, and integrated maintenance design model.
Keywords: Building Maintenance, Building Information Modeling (BIM), Autodesk Revit, Autodesk BIM 360 Ops, building maintenance model
Genetic Correlation of Conformation Traits with Semen Traits in Chinese Holstein Bulls: A Preliminary Investigation
Authors: Yang Jian , Wang Xiao , Xue Jie , Gao Yundong , Li Jianbin
Published: October 2023

The current study conducted a preliminary investigation of genetic correlations in Chinese Holstein bulls to improve their semen quantity and quality by indirect selection of conformation traits. The results of seven semen traits and nine conformation traits showed that the heritability estimates of semen traits ranged from 0.24 (post-thaw motility) to 0.63 (volume per ejaculation), while the conformation traits ranged from 0.29 (pin width) to 0.80 (withers height). Phenotypic correlation between scrotal circumference (SC) and semen concentration per ejaculation (SCPE), SC and total number of sperm per ejaculation (TNS), and SC and total number of motile sperm per ejaculation (TNMS) was 0.22, 0.25, and 0.24, respectively. Genetic correlation between SC and SCPE, SC and TNS, and SC and TNMS was 0.41, 0.40, and 0.38, respectively. To summarize, moderate or high heritability of semen traits indicated that genetic improvement of semen quality by selection is feasible, where SC could be a useful trait for indirect selection or as correlated information to improve semen quantity and production.
ARTIFICIAL INTELLIGENCE IN EDUCATION: TOOL, OBJECT,
“SUBJECT” OF LEARNING
Authors: Varynskyi Vladyslav , Donnikova Iryna , Savinova Nataliia
Published: October 2023

The active development of innovative technologies led to the introduction of artificial intelligence in all spheres of human activity, particularly, in education. As an educational technology, artificial intelligence integrates social, cultural, pedagogical, and legal aspects of application, thereby opening up new opportunities for learning and generating knowledge. At the same time, education faces new problems and challenges, one of which is determining the role of artificial intelligence in the generation of knowledge. The article analyzes the main representations of artificial intelligence in education: as a tool of education, an object of learning, and a “simulative subject”. In the complex system of “artificial intelligence & education & knowledge”, representations of artificial intelligence are considered evolving and becoming more complicated by overcoming contradictions
embedded in systems. To understand the impact of artificial intelligence on education, its
features as a tool of education and as an object of learning are revealed, and productivity and problems that arise are clarified. Special attention is paid to the status of AI as a “simulative subject” in education, whose role in the transformation of “knowledge” into “understanding” is determined by the human teacher. The interdisciplinary theoretical base is represented by studies of thinking, knowledge, and education as complex systems. A phenomenological approach was used to justify the content of learning as a transformation of knowledge into meaning and understanding of the teacher’s role in digital education.
INTERCULTURAL COMMUNICATION AND TOURISM
TRENDS IN POST-PANDEMIC CONTEXT: THEORETICAL
CONSIDERATIONS
Authors: Juraković Linda , Legović Matteo
Published: October 2023

We live in a time where changes in technology, travel and tourism trends,
economic and political systems, migration, and population density have created a world
where we increasingly come into contact with and interact with people of different cultures.
This paper explores and analyzes the connection between intercultural communication
and, one of the most closely related concepts, tourism. On the other hand, in recent years,
all economic structures, including tourism, have been strongly affected by the negative
consequences of the Covid-19 pandemic. In this, already post-pandemic time, all key
stakeholders in tourism are encouraged to reconsider and rethink new, modern, and
innovative post-pandemic tourism characterized by new tourist trends. In this paper the
authors present and elaborate, by analyzing and systematizing key and current literature,
the connection between intercultural communication and tourism, emphasizing current
tourist trends in the post-pandemic context.
Analisis Otentisitas Pengalaman Wisatawan pada Virtual Event Suatu Sanggar Budaya di Saung Angklung Ujo
Authors: Agoes Adrian , Lesmana Andhika Chandra
Published: October 2023

The digital technology that has been around us for a long time has had a significant impact on our lives today. Digital technology is prevalent in many sectors of life, such as entertainment, information search tools, and online shopping and purchasing. It is by far the best choice for society in general during the current pandemic. Saung Angklung Udjo is one of West Java's tourist attraction offering traditional Sundanese arts and culture. With the Covid-19 pandemic, SAU must innovate in order to help the government's agenda in controlling the virus's spread, thus to survive under present conditions. This research examines the authenticity of a tourist's experience after virtually participating in an event hosted by SAU. The study's findings suggest that a virtual show in general has not been able to complete the authenticity of the visitor experience in seeing a cultural performance. However, based on the kind of performances presented by SAU, tourists can still have a genuine experience, particularly in the dimension of Existential Authenticity. This means that, to some extent, the experience of viewing virtual performances offers a sense of authenticity to personal experience, but the experience is not perfect, particularly in the aspects of involvement and interactivity.
Problematic Smartphone Use Among High School Students
Authors: Spiratos Kiva , Ratanasiripong Paul
Published: October 2023

The world currently has more than three billion smartphone users. The smartphone is fully integrated into the daily life of individuals, including 95% of American teenagers. Excessive use of the smartphone leads to smartphone addiction and problematic smartphone use (PSU) which has been associated with depression, stress, reduced self-esteem, and decreased academic performance. This PSU study surveyed high school students grades nine thru twelve from a comprehensive and demographically diverse high school in the United States. This study was conducted with 319 high school students to assess for associations among PSU, depression, stress, self-esteem, grit, and academic performance. Results of this study indicated that students use the smartphone to support learning both inside and outside of the classroom. Results also indicated significant correlations among PSU, depression, stress, self-esteem, grit, and academic performance. Multiple regression analysis found stress, self-esteem, and grit to be significant predictors of PSU.  Implications of this study included informing families, educators, district administrators, and policymakers to more fully and rigorously utilize the electronic device policy provided in California Assembly Bill 272 and to implement more robust and thoughtful classroom smartphone policies and practices. Recommendations are to continue to assess and build awareness of PSU among adolescents, especially post COVID-19 pandemic, when interpersonal relationships and personal connections are a focus of social emotional pandemic recovery.
ТРАНСФОРМАЦІЯ ПІДХОДІВ ДО ЗАБЕЗПЕЧЕННЯ ЕФЕКТИВНОСТІ ВИКОРИСТАННЯ УСТАТКУВАННЯ В ЗАКЛАДАХ РЕСТОРАННОГО БІЗНЕСУ
Authors: Братіцел Марина , Даниленко Ольга , Красовський Сергій
Published: October 2023

Мета наукової статті полягає у дослідженні ефективності використання ресторанного обладнання. Дослідження проводилось шляхом опитування барменів, кухарів та менеджера; розрахунком фактичного коефіцієнта використання встановленого устаткування. Результати опитування показали, що не все устаткування ресторану використовується ефективно. Запропоновано замінити обладнання на більш ефективне. У виробничому процесі ресторану слід задіяти більш дороге обладнання, яке більшу частину часу простоює, деяке обладнання купити, а частину необхідно замінити. Досліджено використання ресторанного обладнання під час блекауту у 2022-2023 рр. Виявлено, що ефективність використання устаткування ресторану зменшилась. Отримані результати можуть бути використані в практичній діяльності досліджуваного ресторану для підвищення його конкурентоспроможності та прибутковості.
РИЗИК-МЕНЕДЖМЕНТ ЯК ІНСТРУМЕНТ УПРАВЛІННЯ ДІЯЛЬНОСТІ СУБʼЄКТІВ ГОСПОДАРЮВАННЯ
Authors: Балдинюк Василь
Published: October 2023

У статті досліджено важливості та ефективності ризик-менеджменту у сучасному бізнесі. Систематизовано основні аспекти ризиків, що виникають на підприємствах. Здійснено аналіз ролі ризик-менеджменту в їх ефективному управлінні. Наголошено на результативності ризик-менеджмент у сприянні зниженню витрат, збільшенню конкурентоспроможності та забезпеченню стійкого розвитку підприємства. Досліджуються ключові методи та стратегії ризик-менеджменту, такі як ідентифікація, оцінка, контроль та мінімізація ризиків, а також прийняття обґрунтованих рішень на основі аналізу ймовірних наслідків. Розглядаються сучасні тенденції у сфері ризик-менеджменту, зокрема, врахування впливу цифровізації та технологічних інновацій на ризики, з якими стикаються підприємства. Наголошено на важливості адаптації стратегій ризик-менеджменту до швидкозмінюваних умов ринку та високих технологічних темпів розвитку. Запропоновано конкретні рекомендації щодо впровадження ефективних моделей ризик-менеджменту на підприємствах різного масштабу, які спрямовані на забезпечення адаптивності та реагування на непередбачувані обставини. Розглядаються приклади успішного застосування ризик-менеджменту в сучасних підприємствах різних секторів економіки, що демонструють його потужний вплив на підвищення стійкості та забезпечення довгострокового успіху. Здійснено вичерпний огляд важливості ризик-менеджменту як стратегічного інструменту управління господарськими ризиками, підкреслюючи його критичну роль у забезпеченні стабільності та стійкого розвитку підприємств у сучасному бізнес-середовищі. Підкреслено важливість впровадження системи ризик-менеджменту на підприємствах для забезпечення їх стійкості та успішності у глобальному економічному середовищі.
ОСОБЛИВОСТІ ТИПОЛОГІЇ ДЕРЖАВНОГО УПРАВЛІННЯ РОЗВИТКОМ СИСТЕМИ ОХОРОНИ ЗДОРОВ’Я
Authors: Шалько М. Н.
Published: October 2023

В статті розглянуто сучасний етап формування системи охорони здоров’я в Україні, який характеризується специфікою економічних взаємин у кризових умовах. У результаті політика у сфері охорони здоров’я, що проводиться державою, впливають на такі основні положення, як: відносини власності; джерела фінансування; механізми стимулювання виробників та споживачів; контроль якості. Охорона здоров’я дозволяє провести диференціацію типів систем охорони здоров’я за різними ознаками. У зв’язку з домінуючим впливом в розвитку соціальної сфери загалом політичних і громадських чинників, саме це становило основу диференціації систем охорони здоров’я і набуло найбільшого поширення розробки теоретичних підходів і практичних методів. В результаті системи охорони здоров’я можна класифікувати за такими типами: класична; соціалістична; національна; плюралістична; страхова. Окрім політичного та суспільного впливу на систему охорони здоров’я впливають інші чинники. Виявлення суті систем охорони здоров’я дозволило виділити такі типи: утилітарна; комунотарна; ліберальна. Запропоновано диференціацію систем охорони здоров’я за принципом виникнення правових відносин між постачальником медичної послуги та її споживачем. Крім того, домінування тих чи інших факторів довкілля дозволило класифікувати систему охорони здоров’я таким чином: державна; страхова; ринкова (приватна). Визначено, що роль держави у формуванні системи охорони здоров’я людини вплинула на виділення наступних типів систем охорони здоров’я: універсалістська; соціального страхування; «Південна модель», де фінансування системи охорони здоров’я здійснюється значною мірою за рахунок коштів, пов’язаних із зайнятістю; інституційна чи соціал-демократична «Скандинавська модель» (Швеція, Данія, Фінляндія), де фінансування охорони здоров’я здійснюється у здебільшого за рахунок прибуткового податку (стягуваного як на національному, так і на місцевому рівні), причому розмір виплачуваної допомоги безпосередньо залежить від заробітку; Континентальна модель (Німеччина, Австрія, Франція, Нідерланди, Бельгія), де фінансування здійснюється за допомогою відрахувань із фонду заробітної плати та зі спеціальних державних фондів, які становлять приблизно ¾ сукупних витрат на охорону здоров’я; Переважно приватна модель (США), де фінансування охорони здоров’я здійснюється за рахунок приватних і, значно меншою мірою, державних джерел, причому надання медичної допомоги здійснюється приватними виробниками медичні послуги.
Activity Reduction as Resilience Indicator: Evidence with Filomena Data
Authors: Santiago-Iglesias Enrique , Schmöcker Jan Dirk , Carpio-Pinedo Jose , García-Palomares Juan Carlos , Sun Wenzhe
Published: October 2023

We explore how different socioeconomic groups adapt to the snowstorm Filomena that occurred in Madrid in 2021. A reverse interpretation of the resilience triangle is proposed, where smaller triangle areas indicate less resilient populations continuing to travel despite disruptions, while larger demand losses indicate greater adaptability. Using Google Popular Times data, the study measures activity levels in neighborhoods, focusing on essential and non-essential trips. Vulnerable groups with lower incomes show limited adaptability, resulting in a smaller reduction in commercial activities compared to affluent neighborhoods. The study emphasizes the significance of considering demand adaptability and socioeconomic factors in assessing resilience.
Invisible Identity in the Workplace: Intersectional Madness and Processes of Disclosure at Work
Authors: Pilling Merrick
Published: October 2023

In this article I draw on recent work regarding disabilities that are not readily apparent to analyze the experiences of lesbian, gay, bisexual, queer, and/or trans (LGBQT) mad people in the workplace. Based on interviews with LGBQT people about madness and everyday life, I use an intersectional approach to examine participants’ work lives. I argue that decisions about disclosure of mental health related information are particularly pressing and high risk at work, given the economic stakes and the effects on health and well-being. As is the case for others with invisible disabilities, notions of authenticity shape processes of disclosure and access to accommodations for LGBQT mad people in the workplace. An intersectional analysis shows how madness cannot be considered the only salient aspect of my participants’ subject positions and how multiple identities operate together to shape their experiences.
Rural Festivals and Rural Cultural Spaces Creation: A Case Study of the “Yim Tin Tsai Arts Festival”
Authors: WENZHEN Minghua Liu , Li Xinyao , Ren Qiyue
Published: October 2023

The “Yim Tin Tsai Arts Festival”, a three-year artistic program, represents a pioneering effort to revitalize rural areas using art as a catalyst. This initiative is designed to explore and address various social issues arising from urbanizing. While rural festivals, including the “Yim Tin Tsai Arts Festival”, play a pivotal role in promoting regional economic development through the creation of cultural spaces, they face the challenge of homogenizing their tourism destination image. This article applies design strategy concepts to explore the impact of rural festivals and cultural spaces on the cultural benefits of the host region, using the “Yim Tin Tsai Arts Festival” in Hong Kong as a case study. Utilizing methods such as desk research and data analysis, this study examines and discusses the significant issues within the field of research regarding the influence of rural festivals and cultural space development. Furthermore, we present the following research focus and development directions for the study of the impact of rural festivals and cultural space development.
The Effect of Profitability, Liquidity and Leverage on Earning Quality with Company Size as a Moderation Variable
Authors: Masruroh Dewi , Apollo
Published: October 2023

The purpose of this study is to examine the Effect of Profitability, Liquidity, and Leverage on Earnings Quality with Company Size as a Moderation Variable (Case Study on the Food and Beverage Sub-Sector Listed on the Indonesia Stock Exchange and Malaysia Stock Exchange in 2018-2021. This research applies secondary data gained from annual reports obtained from the Indonesian Stock Exchange and Malaysia Stock Exchange company websites. The total sampling used in this study is 88 data. The results of this study reveal that profitability significantly negatively affects earnings quality. Significantly, leverage and liquidity do not affect earnings quality. Profitability, liquidity and leverage do not affect earnings quality on company size as a moderation variable. Researchers can develop this study by using different proxies for each variable in order to obtain more robust results.
Pengaruh Kualitas Pelayanan, Nilai Pelanggan dan Citra Merek Terhadap Keputusan Pembelian pada Nadira Hijab Yogyakarta
Authors: Nurhidayati Baiq , Lukitaningsih Ambar , Hutami Lusia Tria Hatmanti
Published: October 2023

This study aims to determine the effect of service quality, customer value and brand image on purchasing decisions. This study took samples who had purchased Nadira Hijab products using a quantitative method. Data collection was carried out using a Google form and the amount of data processed was 66 respondents. The research data were analyzed using multiple linear analysis and the processing was carried out using SPSS version 25. The results of this study indicate that service quality and brand image have a positive effect on purchasing decisions at Nadira Hijab Yogyakarta. Meanwhile, customer value has no positive effect on purchasing decisions at Nadira Hijab Yogyakarta.
Penerapan Konsep Green Marketing dalam Menghasilkan Produk yang Ramah Lingkungan: Sebuah Kajian Konseptual Sebagai Panduan Bagi Peneliti
Authors: Yandi Andri , Muklhlis Imam , Zagladi Arief Noviarakhman
Published: October 2023

This study raises environmental and sustainability issues. This research consists of several parts. First, the literature review focuses on green marketing orientation. Second, the research model and propositions developed in this study are based on a literature review of previous studies, such as the relationship between green marketing orientation towards green innovation and green competitive advantage, the relationship between green innovation and green marketing performance and green competitive advantage, and the relationship between excellence. environmentally friendly competitive. Next, environmentally friendly marketing performance is explored and linked to environmentally friendly marketing performance. In the context of a green marketing orientation strategy, an important role of social marketing theory is that organizational awareness in producing environmentally friendly products is very important for building sustainable competitive advantages in the long term. Thus, this research also shows that environmentally friendly product innovation and environmentally friendly competitive advantages are important strategies for reducing environmentally friendly organizational behavior.
Factor VIII genotype and the risk of developing high-responding or low-responding inhibitors in severe hemophilia A: data from the PedNet Hemophilia Cohort of 1,202 children
Authors: Andersson Nadine G. , Labarque Veerle , Kartal-Kaess Mutlu , Pinto Fernando , Mikkelsen Torben Stamm , Ljung Rolf , Group PedNet Study
Published: October 2023

Not available.
Disease Severity and Clinical Outcome of Coronavirus Vaccinated Patients Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Authors: Sarkar Nirmal Kanti , Roy Moumita , Feroz Salahuddin , Rahman Md Ashadur
Published: October 2023

Background and aims: The severity of illness and mortality in coronavirus disease (COVID-19) may be curtailed byvaccination. We assessed the disease severity and clinical outcome in coronavirus vaccinated patients following SARSCoV-2 infection.
Methods: We conducted an observational study among theSARS-CoV-2 infected patients who received one or two doses of a single generic type of coronavirus vaccine (ChAdOx1nCoV-19, Covishield®, Serum Institute of India) at the outset of vaccine rollout program in Bangladesh. Eligible patients treated at home, outpatient basis, or hospitalized between April 10, 2021, and June 18, 2021, were included. Demographic characteristics, clinical presentation, comorbidities, radiological features, disease severity, treatment protocol, and outcomes were evaluated. The primary end point was disease severity (mild, moderate, severe, and critical).The secondary endpoint was clinical outcome (complete recovery or death) at day 28.
Results: The cohort included total 61 patients. Age ranged between 23–82 year; majority were male (62.3%). Ninety-five percent patients received a single dose of vaccine. Most of the patients had mild symptoms (63.9%), and treated at home (67.2%). Most of the patients recovered utterly (95.1%) without any death. Vaccination showed reduced disease severity (RR 0.93, 95% CI, 0.87-0.99).
Conclusions: In this study it was observed that coronavirus vaccine may significantly lessen disease severity, improve clinical outcome, and prevent death among SARS-CoV-2infected patients.

J Bangladesh Coll Phys Surg 2023; 41(4): 294-297
A Single-Center Experience of Robotic-Assisted Spine Surgery in Korea : Analysis of Screw Accuracy, Potential Risk Factor of Screw Malposition and Learning Curve
Authors: Oh Bu Kwang , Son Dong Wuk , Lee Jun Seok , Lee Su Hun , Kim Young Ha , Sung Soon Ki , Lee Sang Weon , Song Geun Sung , Yi Seong
Published: October 2023

Objective : Recently, robotic-assisted spine surgery (RASS) has been considered a minimally invasive and relatively accurate method. In total, 495 robotic-assisted pedicle screw fixation (RAPSF) procedures were attempted on 100 patients during a 14-month period. The current study aimed to analyze the accuracy, potential risk factors, and learning curve of RAPSF.Methods : This retrospective study evaluated the position of RAPSF using the Gertzbein and Robbins scale (GRS). The accuracy was analyzed using the ratio of the clinically acceptable group (GRS grades A and B), the dissatisfying group (GRS grades C, D, and E), and the Surgical Evaluation Assistant program. The RAPSF was divided into the no-breached group (GRS grade A) and breached group (GRS grades B, C, D, and E), and the potential risk factors of RAPSF were evaluated. The learning curve was analyzed by changes in robot-used time per screw and the occurrence tendency of breached and failed screws according to case accumulation.Results : The clinically acceptable group in RAPSF was 98.12%. In the analysis using the Surgical Evaluation Assistant program, the tip offset was 2.37±1.89 mm, the tail offset was 3.09±1.90 mm, and the angular offset was 3.72°±2.72°. In the analysis of potential risk factors, the difference in screw fixation level (p=0.009) and segmental distance between the tracker and the instrumented level (p=0.001) between the no-breached and breached group were statistically significant, but not for the other factors. The mean difference between the no-breach and breach groups was statistically significant in terms of pedicle width (p<0.001) and tail offset (p=0.042). In the learning curve analysis, the occurrence of breached and failed screws and the robot-used time per screw screws showed a significant decreasing trend.Conclusion : In the current study, RAPSF was highly accurate and the specific potential risk factors were not identified. However, pedicle width was presumed to be related to breached screw. Meanwhile, the robot-used time per screw and the incidence of breached and failed screws decreased with the learning curve.
OPTIMALISASI SEARCH ENGINE & SOCIAL MEDIA MARKETING : STRATEGI MENINGKATKAN MINAT WISATAWAN DI KABUPATEN BANDUNG BARAT (KBB)
Authors: Dinda Kayani Putri Bestari  , Gina Apryani Nurunnisha
Published: October 2023

Indonesia has incredible natural beauty, cultural diversity, and interesting historical values. West Bandung Regency (KBB), is one of the places where tourism is growing rapidly. This is indicated by the number of tourist destinations spread across two divisions (12) sub-districts in the West Bandung Regency (KBB) area, currently the total number of tourist destinations in the KBB area is forty-one destinations. However, based on data from the West Java Regional Opinion Agency, in 2021 there was a decrease in the number of tourists by 44%, this cannot be ignored considering the large potential for regional income from natural tourism in the KBB region. Through this research, the author aims to analyze the utilization of search engine optimization, social media marketing as an effort to increase tourist interest in the West Bandung Regency (KBB) area which ultimately has an impact on customer live value for the tourism sector. The respondents in this study were 150 people who live in Bandung and Jabodetabek. The results of this study indicate that there is a significant influence of the application of SMM and SEO on the formation of brand knowledge and indirectly has an impact on interest in traveling to Sarae Hills tourist area, West Bandung Regency, precisely has a significant impact on preferential and exploratory interest. However, the interactivity indicator in the SMM variable has a fairly low influence, this is because the information conveyed through Sarae Hills social media content is considered informative enough. Furthermore, in the SEO variable, organic search engine optimization is still a solution, considering the impact of organic search optimization has a long-term impact on the formation of company value.
TRABZON'DA PARA VAKIFLARI (1702-1732)
Authors: ÇİÇEK Fatih
Published: October 2023

Vakıflar, Osmanlı Devleti’nde sosyo-iktisadi yönden toplumun yararına olan hizmetlerin düzenli ve sürekli olması adına önemli işlevler üstlenmişlerdir. Osmanlı toplum hayatında vakıflar, kamunun ulaşmadığı şehircilik, eğitim, kültür, dini hizmetler, sosyal hizmetler ve iskân gibi pek çok alan da hizmet götürerek önemli katkılar sunmuştur. Osmanlı vakıf müessesi içinde bir çeşit kredi ve finansman kurumu olan para vakıfları önemli bir yere sahiptir. Osmanlı arşiv belgelerinde vakf-ı nukud olarak ifade edilen para vakıfları XVI. yüzyılın ortalarında itibaren yaygınlaşmaya başlamıştır. Para vakıfları Osmanlı vakıf tecrübesi ekseninde kendine özgü metotları ile Osmanlı Devleti’nde yaklaşık 400 yıl süre ile kendine önemli bir uygulama alanı bulmuştur. Para vakıfları sermayelerini belirli faiz oranları ile ihtiyacı olan kesimleri borç vererek gelir elde etmişlerdir. Para vakıfları Osmanlı Devleti’nde piyasanın ihtiyaç duyduğu finansmanı karşılamanın yanında toplumun ihtiyaç duyduğu hizmetlerin yürütülmesinde parasal destek sunmuştur. Para vakıfları elde ettikleri bu gelirler ile eğitim hizmetleri, maaş ödemeleri, vakıf eserlerinin tamiri, dini yapıların aydınlatılma işleri ve şehircilik hizmetlerinin yürütülmesine katkı sunmuştur.
Bu çalışma, Trabzon şehrine ait şer’iye sicillerinden 1702-1732 yılları arasını ihtiva eden ve bu sicillerden seçilen vakfiye ve vakıf kayıtları esas alınarak hazırlanmıştır. Bu dönemde Trabzon’da para vakıflarının sosyo-iktisadi açıdan vakıf müessesi içerisinde nasıl bir rol oynadıkları irdelenmiştir. Dönemin para vakıfları Trabzon’da vakıf şehir ilişkisi bağlamında hangi alanlara katkı sunduğu görülmeye çalışılmıştır. Trabzon’da para vakfı kuran kesimlerin hangi sosyal sınıfa mensup olduğuna dair bilgiler verilmeye çalışılmıştır. Yine Trabzon para vakıflarının nemalandırma yöntemleri ve kar oranları hakkında belgelere göre değerlendirmeler yapılmıştır. Bu süreçte Trabzon’da para vakıflarının şehrin sosyo-iktisadi hayatının hangi alanlarına destek oldukları tespit edilmeye çalışılmıştır.
Öğretmene Güven ve Algılanan Öğretmen Desteği: Ortaokul ve Lise Öğrencileri Üzerine Bir Araştırma
Authors: Özer Niyazi , Okumuş Hatice , Yıldırım Güven
Published: October 2023

Olumlu öğretmen-öğrenci ilişkilerinin eğitimsel ve davranışsal açıdan öğrenciler üzerinde olumlu etkileri olduğu belirtilmektedir. Bu araştırma ile destekleyici öğretmen davranışları ile öğretmene güven arasındaki ilişkinin ortaokul ve lise öğrencilerinin görüşlerine dayalı olarak belirlenmesi amaçlanmıştır. Ayrıca araştırmada algılanan öğretmen desteği ile öğretmene güven düzeyinin cinsiyet ve okul türü değişkenleri açısından anlamlı farklılık gösterip göstermediği belirlenmeye çalışılmıştır. Veriler 2022-2023 eğitim-öğretim yılında Malatya ili Battalgazi ve Yeşilyurt ilçelerinde bulunan ortaokul (n=759) ve liselerde (n=426) öğrenim gören toplam 1185 öğrenciden toplanmıştır. Araştırmada katılımcılara Öğretmene Güven ve Okul İklimi ölçekleri uygulanmıştır. Araştırma sonucunda cinsiyet ve okul türü açısından anlamlı farklılıklar olduğu belirlenmiştir. Algılanan öğretmen desteği ile öğretmene güven arasında pozitif yönde bir ilişki olduğu, algılanan öğretmen desteğinin öğretmene güvene ait varyansın yaklaşık %71'ini açıkladığı belirlenmiştir.
Emevî Dönemi Su‘lûk Şairlerinden Kattâl el-Kilâbî’nin Şiirlerinde Hapis Teması
Authors: Buhan Yusuf
Published: October 2023

Arap edebiyatı ve kültürüne dair ögelerin bilinmesi ve aktarılmasında şiirlerin rolü yadsınamaz. Toplum içerisinde yaşanan eşitsizlik ve adaletsizliklere bir tepki olarak ortaya çıkan su‘lûk şairlerin kaleme aldıkları şiirler de bu amaca hizmet etmektedir. Klasik Arap şiirinden kısa dizelerden oluşmaları ve atlâl geleneğinin terk edilmesi gibi yönlerden ayrılan bu tür şiirler, dönemin siyasi, sosyal ve kültürel yapısına ışık tutmaktadır. Bu çalışmada su‘lûk hareketi ve su‘lûk şairlerin temel özellikleri Cahiliye, Sadru’l-İslam ve Emevî dönemleri çerçevesinde ele alınmıştır. Buna göre su‘lûk hareketinin başlangıcında bir hak arayışı ve zenginden alıp fakire vermek söz konusuyken özellikle Emevî dönemine gelindiğinde su‘lûk olmanın bir meslek haline geldiği ve siyasi bir anlam içerdiği belirtilebilir. Ayrıca bu çalışmada Emevî döneminde işlediği cinayetlerin çokluğuyla tanınan Kattâl el-Kilâbî’nin hayatına, kişiliğine ve hapis teması bağlamında kaleme aldığı bazı şiirlerine değinilmiştir. Önceki dönemlerde de var olmakla birlikte hapis olgusunun Emevî döneminde yaygınlaştığı ifade edilebilir. Bu çerçevede Kattâl da özgürlüklerine düşkün diğer su‘lûk şairler gibi hapis hayatını, yaşadığı ruhsal gerilimleri, görevlilerin kendisine karşı tutumunu vb. hususları şiirlerine yansıtmıştır. Kabileden soyutlanma, devlet tarafından aranma ve hapse atılma durumu Kattâl’ın göçebe hayat sürdürmesine, yalnızlık, çaresizlik ve karamsarlık duygularına kapılmasına sebebiyet vermiştir. Kattâl’ın hapis hayatına dair yazdığı şiirler üzerinden dönemin hapishane kültürünün yanı sıra bölge, şehir ve yer-mekân isimlerine de ulaşılabilmektedir. Su‘lûk şairlerin ekseriyetinin divanının günümüze ulaşmadığı göz önüne alındığında Kattâl’ın şiirleri, bu alandaki önemli bir boşluğu doldurmaktadır.
Enhancing the deployment of solar energy in Norwegian high-sensitive built environments: challenges and barriers—a scoping review
Authors: Akbarinejad Tahmineh , Machlein Esther , Bertolin Chiara , Lobaccaro Gabriele , Salaj Alenka Temeljotov
Published: October 2023

Heritage and historical buildings often face climate vulnerabilities, decay of technical performance and energy inefficiency that threaten their use and consequently their long-term preservation. Due to urban densification and escalating energy consumption, addressing these vulnerabilities is crucial to protect, rehabilitate and keeping in use historical buildings in cities and utilizing renewable energy sources like solar energy should have a pivotal role towards sustainable cities and communities. However, integrating solar technology into historical buildings faces unique challenges mainly because of the significance, non-standard construction methods adopted, and the valuable original materials. Norway, with its Climate Action Plan and a substantial portion of cultural historic buildings in its building stock, aims to significantly reduce emissions and is seeking for novel solutions. This paper discusses challenges and barriers associated with adoption of solar energy in high-sensitive built environment in Norway, through a scoping review. The results outline conservation criteria as challenges, which include viability, feasibility, integration, reversibility, compatibility, reliability and safety, non-invasiveness, and acceptability. Additionally, the review identifies barriers such as economic, geographic, technical, conservative, legislative, and social factors. Initially, the frequency with which these challenges and barriers appear in academic papers is examined. Subsequently, the interconnections between these challenges and barriers are explored to assess their specific impacts within the Norwegian context. Recognizing these challenges and understanding their interconnection can represent the strength of the relationship between them and can allow to identify potential solutions and strategies to support stakeholders, experts, or public authorities for successfully implementation and integration of solar energy systems in high-sensitive built environments in the future.
Valproic acid reprograms the metabolic aberration of cisplatin treatment via ALDH modulation in triple-negative breast cancer cells
Authors: Granit Mizrahi Avital , Gugenheim Ahinoam , Hamad Haneen , Hamed Roa’a , Tetro Nino , Maimon Ofra , Khutsurauli Salome , Nechushtan Hovav , Nisman Benjamin , Duran Deborah , Samman Widad , Birimberg-Schwartz Liron , Grunewald Myriam , Eyal Sara , Peretz Tamar
Published: October 2023

We recently demonstrated that the histone deacetylase inhibitor valproic acid (VPA) reprograms the cisplatin-induced metabolome of triple-negative breast cancer (TNBC) cells, including a shift in hexose levels. Accordingly, here, we tested the hypothesis that VPA alters glucose metabolism in correlation with cisplatin sensitivity. Two TNBC cell lines, MDA-MB-231 (a cisplatin-resistant line) and MDA-MB-436 (a cisplatin-sensitive line), were analyzed. The glycolysis and oxidative metabolism were measured using the Glycolysis Stress Test kit. The expression of aldehyde dehydrogenases (ALDHs), enzymes linked to drug resistance, was investigated by Western blot and real-time PCR analyses. We additionally studied the influence of ALDH inhibition by disulfiram on the viability of MDA-MB-231 cells and on a TNBC patient-derived organoid system. Cisplatin treatment reduced the extracellular acidification rate in MDA-MB-436 cells but not MDA-MB-231 cells, whereas VPA addition increased the extracellular acidification rate in both cell lines. VPA further reduced the oxygen consumption rate of cisplatin-treated MDA-MB-436 cells, which correlated with cell cycle alterations. However, in MDA-MB-231 cells, the cell cycle distribution did not change between cisplatin/VPA–cisplatin treatments. In both cell lines, VPA increased the expression of ALDH isoform and ALDH1A1 expression. However, only in MDA-MB-231 cells, VPA synergized with cisplatin to augment this effect. Disulfiram sensitized the cells to the cytotoxic effects of the VPA–cisplatin combination. Furthermore, the disulfiram–VPA–chemotherapy combination was most effective in TNBC organoids. Our results show that ALDH overexpression may act as one mechanism of cellular resistance to VPA in TNBC and that its inhibition may enhance the therapeutic efficacy of VPA–chemotherapeutic drug combinations.
Unravelling the functional development of vertebrate pathways controlling gaze
Authors: Barandela Marta , Núñez-González Carmen , Suzuki Daichi G. , Jiménez-López Cecilia , Pombal Manuel A. , Pérez-Fernández Juan
Published: October 2023

Animals constantly redirect their gaze away or towards relevant targets and, besides these goal-oriented responses, stabilizing movements clamp the visual scene avoiding image blurring. The vestibulo-ocular (VOR) and the optokinetic reflexes are the main contributors to gaze stabilization, whereas the optic tectum integrates multisensory information and generates orienting/evasive gaze movements in all vertebrates. Lampreys show a unique stepwise development of the visual system whose understanding provides important insights into the evolution and development of vertebrate vision. Although the developmental emergence of the visual components, and the retinofugal pathways have been described, the functional development of the visual system and the development of the downstream pathways controlling gaze are still unknown. Here, we show that VOR followed by light-evoked eye movements are the first to appear already in larvae, despite their burrowed lifestyle. However, the circuits controlling goal-oriented responses emerge later, in larvae in non-parasitic lampreys but during late metamorphosis in parasitic lampreys. The appearance of stabilizing responses earlier than goal-oriented in the lamprey development shows a stepwise transition from simpler to more complex visual systems, offering a unique opportunity to isolate the functioning of their underlying circuits.
Unravelling the sexual developmental biology of Cystoisospora suis, a model for comparative coccidian parasite studies
Authors: Cruz-Bustos Teresa , Dolezal Marlies , Feix Anna Sophia , Ruttkowski Bärbel , Hummel Karin , Razzazi-Fazeli Ebrahim , Joachim Anja
Published: October 2023

Introduction

The apicomplexan parasite Cystoisospora suis has global significance as an enteropathogen of suckling piglets. Its intricate life cycle entails a transition from an asexual phase to sexual development, ultimately leading to the formation of transmissible oocysts.

Methods

To advance our understanding of the parasite’s cellular development, we complemented previous transcriptome studies by delving into the proteome profiles at five distinct time points of in vitro cultivation through LC/MS-MS analysis.

Results

A total of 1,324 proteins were identified in the in vitro developmental stages of C. suis, and 1,082 proteins were identified as significantly differentially expressed. Data are available via ProteomeXchange with identifier PXD045050. We performed BLAST, GO enrichment, and KEGG pathway analyses on the up- and downregulated proteins to elucidate correlated events in the C. suis life cycle. Our analyses revealed intriguing metabolic patterns in macromolecule metabolism, DNA- and RNA-related processes, proteins associated with sexual stages, and those involved in cell invasion, reflecting the adaptation of sexual stages to a nutrient-poor and potentially stressful extracellular environment, with a focus on enzymes involved in metabolism and energy production.

Discussion

These findings have important implications for understanding the developmental biology of C. suis as well as other, related coccidian parasites, such as Eimeria spp. and Toxoplasma gondii. They also support the role of C. suis as a new model for the comparative biology of coccidian tissue cyst stages.