bluuebunny/crossref_metadata_2025 huggingface dataset:
Divergent effects of cold water immersion versus active recovery on skeletal muscle fiber type and angiogenesis in young men
Authors: D’Souza Randall F. , Zeng Nina , Markworth James F. , Figueiredo Vandre C. , Roberts Llion A. , Raastad Truls , Coombes Jeff S. , Peake Jonathan M. , Cameron-Smith David , Mitchell Cameron J.
Published: February 2018

Resistance training (RT) increases muscle fiber size and induces angiogenesis to maintain capillary density. Cold water immersion (CWI), a common postexercise recovery modality, may improve acute recovery, but it attenuates muscle hypertrophy compared with active recovery (ACT). It is unknown if CWI following RT alters muscle fiber type expression or angiogenesis. Twenty-one men strength trained for 12 wk, with either 10 min of CWI ( n = 11) or ACT ( n = 10) performed following each session. Vastus lateralis biopsies were collected at rest before and after training. Type IIx myofiber percent decreased ( P = 0.013) and type IIa myofiber percent increased with training ( P = 0.012), with no difference between groups. The number of capillaries per fiber increased from pretraining in the CWI group ( P = 0.004) but not the ACT group ( P = 0.955). Expression of myosin heavy chain genes ( MYH1 and MYH2), encoding type IIx and IIa fibers, respectively, decreased in the ACT group, whereas MYH7 (encoding type I fibers) increased in the ACT group versus CWI ( P = 0.004). Myosin heavy chain IIa protein increased with training ( P = 0.012) with no difference between groups. The proangiogenic vascular endothelial growth factor protein decreased posttraining in the ACT group versus CWI ( P < 0.001), whereas antiangiogenic Sprouty-related, EVH1 domain-containing protein 1 protein increased with training in both groups ( P = 0.015). Expression of microRNAs that regulate muscle fiber type (miR-208b and -499a) and angiogenesis (miR-15a, -16, and -126) increased only in the ACT group ( P < 0.05). CWI recovery after each training session altered the angiogenic and fiber type-specific response to RT through regulation at the levels of microRNA, gene, and protein expression.
Learned rather than online relative weighting of visual-proprioceptive sensory cues
Authors: Mikula Laura , Gaveau Valérie , Pisella Laure , Khan Aarlenne Z. , Blohm Gunnar
Published: February 2018

When reaching to an object, information about the target location as well as the initial hand position is required to program the motor plan for the arm. The initial hand position can be determined by proprioceptive information as well as visual information, if available. Bayes-optimal integration posits that we utilize all information available, with greater weighting on the sense that is more reliable, thus generally weighting visual information more than the usually less reliable proprioceptive information. The criterion by which information is weighted has not been explicitly investigated; it has been assumed that the weights are based on task- and effector-dependent sensory reliability requiring an explicit neuronal representation of variability. However, the weights could also be determined implicitly through learned modality-specific integration weights and not on effector-dependent reliability. While the former hypothesis predicts different proprioceptive weights for left and right hands, e.g., due to different reliabilities of dominant vs. nondominant hand proprioception, we would expect the same integration weights if the latter hypothesis was true. We found that the proprioceptive weights for the left and right hands were extremely consistent regardless of differences in sensory variability for the two hands as measured in two separate complementary tasks. Thus we propose that proprioceptive weights during reaching are learned across both hands, with high interindividual range but independent of each hand’s specific proprioceptive variability.

NEW & NOTEWORTHY How visual and proprioceptive information about the hand are integrated to plan a reaching movement is still debated. The goal of this study was to clarify how the weights assigned to vision and proprioception during multisensory integration are determined. We found evidence that the integration weights are modality specific rather than based on the sensory reliabilities of the effectors.
A General Maximum Progression Model to Concurrently Synchronize Left-Turn and through Traffic Flows on an Arterial
Authors: Jing Binbin , Xu Jianmin
Published: February 2018

In the existing bandwidth-based methods, through traffic flows are considered as the coordination objects and offered progression bands accordingly. However, at certain times or nodes in the road network, when the left-turn traffic flows have a higher priority than the through traffic flows, it would be inappropriate to still provide the progression bands to the through traffic flows; the left-turn traffic flows should instead be considered as the coordination objects to potentially achieve better control. Considering this, a general maximum progression model to concurrently synchronize left-turn and through traffic flows is established by using a time-space diagram. The general model can deal with all the patterns of the left-turn phases by introducing two new binary variables into the constraints; that is, these variables allow all the patterns of the left-turn phases to deal with a single formulation. By using the measures of effectiveness (average delay time, average vehicle stops, and average travel time) acquired by a traffic simulation software, VISSIM, the validity of the general model is verified. The results show that, compared with the MULTIBAND, the proposed general model can effectively reduce the delay time, vehicle stops, and travel time and, thus, achieve better traffic control.
The Potential Virulence Factors ofProvidencia stuartii: Motility, Adherence, and Invasion
Authors: Kurmasheva Naziia , Vorobiev Vyacheslav , Sharipova Margarita , Efremova Tatyana , Mardanova Ayslu
Published: February 2018

Providencia stuartiiis the most commonProvidenciaspecies capable of causing human infections. CurrentlyP. stuartiiis involved in high incidence of urinary tract infections in catheterized patients. The ability of bacteria to swarm on semisolid (viscous) surfaces and adhere to and invade host cells determines the specificity of the disease pathogenesis and its therapy. In the present study we demonstrated morphological changes ofP. stuartiiNK cells during migration on the viscous medium and discussed adhesive and invasive properties utilizing the HeLa-M cell line as a host model. To visualize the interaction ofP. stuartiiNK bacterial cells with eukaryotic cellsin vitroscanning electron and confocal microscopy were performed. We found that bacteriaP. stuartiiNK are able to adhere to and invade HeLa-M epithelial cells and these properties depend on the age of bacterial culture. Also, to invade the host cells the infectious dose of the bacteria is essential. The microphotographs indicate that after incubation of bacterialP. stuartiiNK cells together with epithelial cells the bacterial cells both were adhered onto and invaded into the host cells.
Retailer’s Joint Ordering, Pricing, and Preservation Technology Investment Policies for a Deteriorating Item under Permissible Delay in Payments
Authors: Mishra Umakanta , Tijerina-Aguilera Jacobo , Tiwari Sunil , Cárdenas-Barrón Leopoldo Eduardo
Published: February 2018

This article develops an inventory model for deteriorating items with controllable deterioration rate (by using preservation technology) under trade credit policy. As in practical scenarios the demand of an item is directly associated with its selling price, keeping this in mind, it is assumed to be a price dependent demand. The main objective of the inventory model is to determine jointly the optimal ordering, pricing, and preservation technology investment policies for retailer so that the total profit is maximized. The effects of key parameters on optimal solution are studied through a sensitivity analysis with the aim of examining the behavior of the inventory model with controllable deterioration under the permissible delay in payments.
Mechanism Analysis of Spalling Defect on Rail Surface under Rolling Contact Conditions
Authors: Yang Rongshan , Cao Shihao , Kang Weixin , Li Jiali , Jiang Xiaoyu
Published: February 2018

Under the wheel/rail contact loading conditions, the microcracks on the rail surface propagate, leading to spalling defect or rail fracture and threatening the travelling safety of high-speed railway directly. In order to analyze the mechanism of the crack propagation on the rail surface, the calculation model of the wheel/rail contact fatigue was established, and the variation of the stress intensity factor at the crack tip when the crack length was increased from 0.1 mm to 2 mm was obtained. Based on the mixed-mode fracture criterion and Paris growth theory, the mechanism of the crack propagation on the rail surface was analyzed. The results show that when the microcrack grows to macrocrack, the mode of the fatigue crack on the rail surface is mixed including sliding mode and open mode. With the increase of the crack length, the stress intensity factor KI increases first and then decreases gradually, and the relative dangerous location of the open-mode crack moves from the inner edge of the contact area to the outer edge, while the factor KII is increasing during the whole propagation process, and the relative dangerous location of the sliding-mode crack remains unchanged basically. The main failure mode of crack is open during the initial stage and then transforms into sliding mode with the crack length increasing. The crack tends to propagate upward and leads to spalling defect when the crack length is between 0.3 and 0.5 mm. This propagation path is basically identical with the spalling path of the service rail. The research results will provide a basis for improving the antifatigue performance of rail and establishing the grinding procedure.
Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms
Authors: Banawas Saeed S.
Published: February 2018

Clostridium difficile (C. difficile) is the most prevalent causative pathogen of healthcare-associated diarrhea. Notably, over the past 10 years, the number of Clostridium difficile outbreaks has increased with the rate of morbidity and mortality. The occurrence and spread of C. difficile strains that are resistant to multiple antimicrobial drugs complicate prevention as well as potential treatment options. Most C. difficile isolates are still susceptible to metronidazole and vancomycin. Incidences of C. difficile resistance to other antimicrobial drugs have also been reported. Most of the antibiotics correlated with C. difficile infection (CDI), such as ampicillin, amoxicillin, cephalosporins, clindamycin, and fluoroquinolones, continue to be associated with the highest risk for CDI. Still, the detailed mechanism of resistance to metronidazole or vancomycin is not clear. Alternation in the target sites of the antibiotics is the main mechanism of erythromycin, fluoroquinolone, and rifamycin resistance in C. difficile. In this review, different antimicrobial agents are discussed and C. difficile resistance patterns and their mechanism of survival are summarized.
The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis
Authors: Rosito Letícia Petersen Schmidt , Sperling Neil , Teixeira Adriane Ribeiro , Selaimen Fábio André , Costa Sady Selaimen da
Published: February 2018

Objective. To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE.Methods. Videotoscopy of both ears in 432 patients with cholesteatomas classified as posterior epitympanic (PEC), posterior mesotympanic (PMC), two routes, or undetermined. Tympanic membrane (TM) retractions were classified by location and severity and TM perforations according to signs of previous TM retraction.Results. TM retraction was the most prevalent alteration in the CLE (42.6%). Cholesteatoma was observed in 17.4%. In patients with PEC, the retraction in the CLE was more frequent in the PF (66.7%) than in the PT (1.4%), and in those with two-route cholesteatoma, the retraction in the CLE most frequently involved both the PT and PF (65.6%;p<0.0001).Conclusion. Our results confirm the essential role of TM retraction at least in the earlier phases of cholesteatoma pathogenesis.
Changes in Dietary Patterns and the Nutritional Status in Men in the Metallurgical Industry in Poland Over A 21-Year Period
Authors: Charkiewicz Angelika Edyta , Jamiołkowski Jacek , Pędziński Bartosz , Krzyżak Michalina , Maślach Dominik , Szpak Andrzej , Omeljaniuk Wioleta Justyna
Published: February 2018

Background/Aims: The study was carried out to evaluate the changes in the eating habits and lipid parameters in a 21-year follow-up on a group of 435 men living in Poland. Methods: The studied population was composed of the same subjects: a group of men who were first studied in the years 1987–1989 and in 2008–2010. The following data was gathered: body mass, body mass index (BMI), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride concentration in blood serum. Results: The changes in the eating habits among the studied men registered throughout the 21-year period were positive since they showed a reduction in the caloric content of their diet (p < 0.001), lower total fat content (p < 0.001), total amount of carbohydrates (p < 0.001), sucrose (p < 0.001), iron (p < 0.001), and featured more vitamins: A (p < 0.002), B1 (p < 0.001), and C (p < 0.001). An adverse trend was observed in terms of constant calcium shortages in their food portions (ns). A 21-year follow-up of the studied group showed significant differences in terms of weight (p < 0.001), BMI (p < 0.001), and all cholesterol fractions (p < 0.001) in their blood serum, except cholesterol alone (ns). Conclusion: It is important to continue observing the dietary trends in the studied group, with the focus on the occurrence of potential changes in their bodies.
A Surgically Resected Pancreatic Schwannoma with Obstructive Jaundice with Special Reference to Differential Diagnosis from Other Cystic Lesions in the Pancreas
Authors: Watanabe Takayoshi , Araki Kenichiro , Ishii Norihiro , Igarashi Takamichi , Watanabe Akira , Kubo Norio , Kuwano Hiroyuki , Shirabe Ken
Published: February 2018

Pancreatic schwannomas are uncommon. About 60% of pancreatic schwannomas develop cystic lesions, and the differential diagnosis from other cystic pancreatic tumors is difficult. A 43-year-old man presented for evaluation of liver dysfunction detected during a medical checkup. Blood testing detected obstructive jaundice. A computed tomography scan revealed a well-defined polycystic tumor of about 5 cm at the pancreatic head. We performed surgical resection to treat the patient’s symptoms and facilitate long-term management. Histopathological examination revealed spindle-shaped cells. Immunohistochemical studies showed S100 protein expression and the absence of CD34 and c-kit protein expression. Finally, we diagnosed a schwannoma. Pancreatic schwannoma is usually asymptomatic. The present case presented with obstructive jaundice, which is reportedly a rare symptom. Pancreatic schwannomas should be considered as a differential diagnosis of pancreatic cystic tumors. Dilatation of the pancreatic duct and the 18-fluorodeoxyglucose positron emission tomography findings are important for the differential diagnosis.
Grandiose and Vulnerable Narcissism in Borderline Personality Disorder
Authors: Euler Sebastian , Stöbi Dominik , Sowislo Julia , Ritzler Franziska , Huber Christian G. , Lang Undine E. , Wrege Johannes , Walter Marc
Published: February 2018

Background: Little is known about narcissistic traits in borderline personality disorder (BPD). This exploratory study aimed to illustrate the associations between total, grandiose, and vulnerable narcissism and gender, diagnostic features of BPD and narcissistic personality disorder (NPD), and psychopathology in BPD patients. Sampling and Methods: The Pathological Narcissism Inventory and psychometric measures for impulsivity, anger, borderline symptom severity, personality organization, depression, and rejection sensitivity were completed by 65 BPD patients. Statistical analyses were conducted using the t test, Pearson correlation, and multivariate regression analyses. Results: Male BPD patients displayed higher narcissistic scores than females (p < 0.01). Grandiose narcissism showed a stronger association with NPD than with BPD (p < 0.01) while vulnerable narcissism was only associated with BPD (p < 0.01). Rejection sensitivity (p < 0.01) and depression (p < 0.001) predicted vulnerable narcissism. Conclusion: Vulnerable narcissism is closely associated with BPD and appears to be more dysfunctional than grandiose narcissism. A comprehensive consideration of both traits is recommended. Our results might help to generate hypotheses for further research on pathological narcissism in the spectrum of personality disorders. Future studies are advised to apply complementary measures and take new diagnostic approaches of DSM-5 and ICD-11 into account.
Benzodiazepines as a Monotherapy in Depressive Disorders: A Systematic Review
Authors: Benasi Giada , Guidi Jenny , Offidani Emanuela , Balon Richard , Rickels Karl , Fava Giovanni A.
Published: February 2018

Background: The aim of this paper was to perform a systematic review and, when feasible, a meta-analysis of randomized controlled trials (RCT) which used benzodiazepines (BZD) as a monotherapy versus placebo, antidepressant drugs (AD), or both. Methods: Keyword searches were conducted for identifying RCT comparing BZD and AD, and/or placebo in the treatment of depression, using electronic databases from their inception up to April 2017. We selected reports of RCT in which BZD were compared to AD and/or placebo in the treatment of adult patients with a primary diagnosis of depressive disorder or anxious depression. When feasible, data were subjected to meta-analysis. Results: A total of 38 studies met the criteria for inclusion and were then included in the systematic review. Only 1 study concerned a newer AD, fluvoxamine. For the meta-analysis, we submitted data on response rate from 22 RCT, considering BZD versus placebo (8 comparisons) and BZD versus tricyclic antidepressants (TCA) (20 comparisons). There was a lack of significant differences as to response rate between BZD and placebo, as well as between BZD and TCA. Analysis of individual studies disclosed that, in more than half of the studies comparing BZD to TCA and/or placebo, BZD were significantly more effective than placebo and as effective as TCA. Conclusions: BZD are a therapeutic option in anxious depression and there are no indications that AD are preferable. There is a pressing need for RCT of adequate methodological quality and follow-up comparing BZD to second-generation AD and placebo in anxious depression.
A Prospective Cohort Study in Patients with Type 2 Diabetes Mellitus for Validation of Biomarkers (PROVALID) – Study Design and Baseline Characteristics
Authors: Eder Susanne , Leierer Johannes , Kerschbaum Julia , Rosivall Laszlo , Wiecek Andrzej , de Zeeuw Dick , Mark Patrick B. , Heinze Georg , Rossing Peter , Heerspink Hiddo L. , Mayer Gert
Published: February 2018

Background/Aims: The prevalence of diabetes mellitus type 2 and kidney disease in these patients varies widely between European countries. Methods: In addition to store bio-samples the “Prospective cohort study in patients with type 2 diabetes mellitus for validation of biomarkers” collects information on history, physical status, laboratory measurements and medication in 4000 patients with diabetes mellitus type 2, being taken care of at the primary level of healthcare in 5 European countries (Austria, Hungary, Netherlands, Poland and Scotland). Next to comparing the rate of loss of eGFR between the countries, a further objective of the PROVALID study is to determine the 5-year cumulative incidence of renal and cardiovascular outcomes. Results: The mean age of the population recruited is 62.9±10 years, 54.6% are male and the mean BMI is 30.9±5.4 kg/m2. Metabolic control (median HBA1c 6.8 % (6.2; 7.5)) is achieved via administration of metformin in 67.4% of the patients and insulin in 30.3%. Median systolic and diastolic blood pressure at recruitment is 135 (125; 146) and 80 (72; 85) mmHg, 65.4% of subjects received RAAS blocking agents. Mean eGFR is 80.7±29.2 ml/min/1.73m2 and median baseline albumin/creatinine ratio 8.3 mg (IQR: 3.8 and 25.1). Conclusion: PROVALID will provide information on incidence and progression of renal and cardiovascular disease and therapy in patients with type 2 diabetes mellitus in different European countries. Thus, in contrast to many other cohort studies we will be able to associate national clinical practise pattern with outcome in this highly vulnerable patient population.
Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis
Authors: Fan Yanbo , Lu Haocheng , Liang Wenying , Garcia-Barrio Minerva T. , Guo Yanhong , Zhang Ji , Zhu Tianqing , Hao Yibai , Zhang Jifeng , Chen Y. Eugene
Published: February 2018

Rationale:

Postischemic angiogenesis is critical to limit the ischemic tissue damage and improve the blood flow recovery. The regulation and the underlying molecular mechanisms of postischemic angiogenesis are not fully unraveled.
TFEB
(transcription factor EB) is emerging as a master gene for autophagy and lysosome biogenesis. However, the role of TFEB in vascular disease is less understood.

Objective:

We aimed to determine the role of endothelial TFEB in postischemic angiogenesis and its underlying molecular mechanism.

Methods and Results:

In primary human endothelial cells (ECs), serum starvation induced TFEB nuclear translocation. VEGF (vascular endothelial growth factor) increased TFEB expression level and nuclear translocation. Utilizing genetically engineered EC-specific TFEB transgenic and KO (knockout) mice, we investigated the role of TFEB in postischemic angiogenesis in the mouse hindlimb ischemia model. We observed improved blood perfusion and increased capillary density in the EC-specific TFEB transgenic mice compared with the wild-type littermates. Furthermore, blood flow recovery was attenuated in EC-TFEB KO mice compared with control mice. In aortic ring cultures, the TFEB transgene significantly increased vessel sprouting, whereas TFEB deficiency impaired the vessel sprouting. In vitro, adenovirus-mediated TFEB overexpression promoted EC tube formation, migration, and survival, whereas siRNA-mediated TFEB knockdown had the opposite effect. Mechanistically, TFEB activated AMPK (AMP-activated protein kinase)-α signaling and upregulated autophagy. Through inactivation of AMPKα or inhibition of autophagy, we demonstrated that the AMPKα and autophagy are necessary for TFEB to regulate angiogenesis in ECs. Finally, the positive effect of TFEB on AMPKα activation and EC tube formation was mediated by TFEB-dependent transcriptional upregulation of MCOLN1 (mucolipin-1).

Conclusions:

In summary, our data demonstrate that TFEB is a positive regulator of angiogenesis through activation of AMPKα and autophagy, suggesting that TFEB constitutes a novel molecular target for ischemic vascular disease.
Delimitation of Flatness in Paintings
Authors: Schinckus Christophe
Published: February 2018

This essay is a double exemplification: the first is a visual one based on Goodman’s theory of symbols showing that art can exemplify the delimitation of the flatness. I illustrate this claim with five achromatic paintings contrasting the materiality of the canvas with its visual elements. By emphasizing the epistemic nature of arts, this article also suggests a second exemplification: the use of visual elements to question their geometric associations.
Simulating Extreme Etesians over the Aegean and Implications for Wind Energy Production in Southeastern Europe
Authors: Dafka Stella , Toreti Andrea , Luterbacher Juerg , Zanis Prodromos , Tyrlis Evangelos , Xoplaki Elena
Published: February 2018

Episodes of extremely strong northerly winds (known as etesians) during boreal summer can cause hazardous conditions over the Aegean Archipelago (Greece) and represent a threat for the safe design, construction, and operation of wind energy turbines. Here, these extremes are characterized by employing a peak-over-threshold approach in the extended summer season (May–September) from 1989 to 2008. Twelve meteorological stations in the Aegean are used, and results are compared with 6-hourly wind speed data from five ERA-Interim–driven regional climate model (RCM) simulations from the European domain of the Coordinated Regional Climate Downscaling Experiment (EURO-CORDEX). The main findings show that, in the range of wind speeds for the maximum power output of the turbine, the most etesian-exposed stations could operate 90% at a hub height of 80 m. The central and northern Aegean are identified as areas prone to wind hazards, where medium- to high-wind (class II or I according to the International Electrotechnical Committee standards) wind turbines could be more suitable. In the central Aegean, turbines with a cutout wind speed > 25 m s−1are recommended. Overall, RCMs can be considered a valuable tool for investigating wind resources at regional scale. Therefore, this study encourages a broader use of climate models for the assessment of future wind energy potential over the Aegean.
Sensitivity of Surface Temperature to Oceanic Forcing via q-Flux Green’s Function Experiments. Part I: Linear Response Function
Authors: Liu Fukai , Lu Jian , Garuba Oluwayemi , Leung L. Ruby , Luo Yiyong , Wan Xiuquan
Published: February 2018

This paper explores the use of the linear response function (LRF) to relate the mean sea surface temperature (SST) response to prescribed ocean heat convergence (q flux) forcings. Two methods for constructing the LRF based on the fluctuation–dissipation theorem (FDT) and Green’s function (GRF) are examined. A 900-yr preindustrial simulation by the Community Earth System Model coupled with a slab ocean model (CESM–SOM) is used to estimate the LRF using FDT. For GRF, 106 pairs of CESM–SOM simulations with warm and cold q-flux patches are performed. FDT is found to have some skill in estimating the SST response to a q-flux forcing when the local SST response is strong, but it fails in inverse estimation of the q-flux forcing for a given SST pattern. In contrast, GRF is shown to be reasonably accurate in estimating both SST response and q-flux forcing. Possible degradation in FDT may be attributed to insufficient data sampling, significant departure of the SST distribution from Gaussianity, and the nonnormality of the constructed operator. The GRF-based LRF is then used to (i) generate a global surface temperature sensitivity map that shows the q-flux forcing in higher latitudes to be 3–4 times more effective than low latitudes in producing global surface warming, and (ii) identify the most excitable SST mode (neutral vector) that shows marked resemblance to the interdecadal Pacific oscillation (IPO). The latter discovery suggests that the IPO-like fluctuation exists in the absence of the coupling to the ocean dynamics. Coupling to the ocean dynamics in CESM, on the other hand, only enhances the spectral power of the IPO at interannual time scales.
Climatological Aspects of Convective Parameters over Europe: A Comparison of ERA-Interim and Sounding Data
Authors: Taszarek Mateusz , Brooks Harold E. , Czernecki Bartosz , Szuster Piotr , Fortuniak Krzysztof
Published: February 2018

We compare over 1 million sounding measurements with ERA-Interim reanalysis for the 38-yr period from 1979 to 2016. The large dataset allows us to provide an improved insight into the spatial and temporal distributions of the prerequisites of deep moist convection across Europe. In addition, ERA-Interim is also evaluated. ERA-Interim estimates parameters describing boundary layer moisture and midtropospheric lapse rates well, with correlation coefficients of 0.94. Mixed-layer CAPE is, on average, underestimated by the reanalysis while the most unstable CAPE is overestimated. Vertical shear parameters in the reanalysis are better correlated with observations than CAPE, but are underestimated by approximately 1–2 m s−1. The underestimation decreases as the depth of the shear layer increases. Compared to radiosonde observations, instability in ERA-Interim is overestimated in southern Europe and underestimated over eastern Europe. High values of instability are observed from May to September, out of phase with the climatological pattern of wind shear, which peaks in winter. From September to April, favorable conditions for thunderstorms occur mainly over southern and western Europe with the peak location and higher frequency shifting to central and eastern Europe from May to August. For southern Europe, the annual cycle peaks in September with high values of inhibition suppressing thunderstorm activity in July and August. The area with the highest annual number of days with environmental conditions favorable for thunderstorms extends from Italy and Austria eastward through the Carpathians and Balkans.
Counseling Psychology Model Training Program
Authors: Scheel Michael J. , Stabb Sally D. , Cohn Tracy J. , Duan Changming , Sauer Eric M.
Published: February 2018

The counseling psychology Model Training Program (MTP) was written to reflect new developments in counseling psychology, the American Psychological Association, and the world. The updated MTP is aspirational, intended to guide the development and maintenance of counseling psychology programs. The MTP conforms to the American Psychological Association’s and the Society of Counseling Psychology’s standards and guidelines. A strategic task group appointed by 2015 Society president James W. Lichtenberg sought feedback from the field to assist in its formulation, and the executive boards of the Society and the Council of Counseling Psychology Training Programs approved the final version. The 2017 MTP consists of four core values (i.e., growth toward full potential, holistic and contextual, diversity and social justice, communitarian perspective) as well as 20 principles grouped into six clusters: counseling psychology identity; multiculturalism, diversity, and social justice; health service psychology; developmental, prevention, and strengths orientation; science–practice integration; and relationships within and between professional communities.
Theorizing an Africana Womanist’s Resistance to Patriarchy in Monyaise’s Bogosi Kupe
Authors: Makgato Mary , Chaka Chaka , Mandende Itani
Published: February 2018

This article examines the resistance of an African woman to patriarchy in the Setswana novel, Bogosi Kupe. To illustrate this resistance, it analyzes a woman protagonist, Matlhodi, in this Setswana novel. The article contends that Matlhodi employs self-defining and authentic stratagems to counteract both patriarchal hegemony, and familial, cultural, and ideological hegemony. Employing Africana womanism and Africana critical theory, it argues that Matlhodi deploys her body, her clandestine love affair, her pregnancy, and her husband’s death as weapons to resist the patriarchal ethos foisted on her by her family.
Experimental test and analytical modeling of mechanical properties of graphene-oxide cement composites
Authors: Duan Zhongcheng , Zhang Li , Lin Zhiyuan , Fan Ding , Saafi Mohamed , Castro Gomes João , Yang Shangtong
Published: February 2018

Graphene oxide has recently been considered as an ideal candidate for enhancing the mechanical properties of the cement due to its good dispersion property and high surface area. Much of work has been done on experimentally investigating the mechanical properties of graphene oxide-cementitious composites; but there are currently no models for accurate estimation of their mechanical properties, making proper analysis and design of graphene oxide-cement-based materials a major challenge. This paper attempts to develop a novel multi-scale analytical model for predicting the elastic modulus of graphene oxide-cement taking into account the graphene oxide/cement ratio, porosity and mechanical properties of different phases. This model employs Eshelby tensor and Mori-Tanaka solution in the process of upscaling the elastic properties of graphene oxide-cement through different length scales. In-situ micro-bending tests were conducted to elucidate the behaviour of the graphene oxide-cement composites and verify the proposed model. The obtained results showed that the addition of graphene oxide can change the morphology and enhance the mechanical properties of the cement. The developed model can be used as a tool to determine the elastic properties of graphene oxide-cement through different length scales.
Mixed-mode I/II interlaminar fracture toughness of carbon fiber/epoxy composites with the addition of multiwalled carbon nanotubes by spraying technique
Authors: Rodríguez-González JA , Rubio-González C
Published: February 2018

This work reports the effect of multiwalled carbon nanotubes on mixed-mode I/II interlaminar fracture toughness ([Formula: see text]) of unidirectional carbon fiber/epoxy composite laminates made by prepregs. The carbon fiber/epoxy laminates were fabricated in an autoclave with a previous deposition of different multiwalled carbon nanotube contents at their middle plane interface by spraying technique. Mixed-mode bending tests were conducted on carbon fiber/epoxy laminate specimens under different mixed-mode ratios. The results of mixed-mode bending tests showed that the addition of multiwalled carbon nanotubes can effectively improve the [Formula: see text] of carbon fiber/epoxy laminates. With a 0.2 wt.% multiwalled carbon nanotubes content in carbon fiber/epoxy laminates, the [Formula: see text] under mixed-mode ratios of 0.2, 0.5 and 0.8 increased by 25%, 12% and 19%, respectively. These results were explained in terms of the damage mechanisms observed at the fracture surfaces of tested specimens by scanning electron microscopy.
Practice Patterns of Referring Physicians in Management of the Dysphonic Patient
Authors: Holcomb Andrew J. , Hamill Chelsea S. , Irwin Thomas , Sykes Kevin , Garnett James D. , Kraft Shannon
Published: February 2018

Objective

Dysphonia is commonly encountered by primary care physicians and general otolaryngologists. We examine practice patterns of referring physicians to a tertiary voice clinic, including adherence to evidence‐based guidelines.

Study Design

Retrospective case series with chart review.

Setting

Academic tertiary care hospital.

Subjects and Methods

In total, 821 charts of patients with voice complaints seen at a tertiary voice clinic between January 2011 and June 2016 were reviewed. Included charts (n = 755) were reviewed for type of referring provider, prior diagnoses, and treatments employed by referring physicians. Additional information regarding findings at the time of laryngoscopy/stroboscopy and diagnoses provided by a laryngologist were also obtained. Statistical analysis was performed to determine significant relationships between variables of interest.

Results

A total of 244 patients (32.2%) received a diagnosis prior to evaluation in the voice clinic, most commonly laryngopharyngeal reflux disease (n = 134). Prior medical treatment was attempted in 221 (29.3%) patients, typically antireflux medications (n = 141). Of the patients treated with proton pump inhibitors by referring physicians, 65.1% lacked symptoms of gastroesophageal reflux disease. Patients with prior treatment had a median duration of symptoms 6 weeks longer than those without prior treatment (P =. 04). Among previously diagnosed patients, 199 (81.6%) of diagnoses changed after evaluation in the voice clinic.

Conclusion

Referring physicians frequently treat dysphonic patients empirically, often with antireflux medications. Subspecialist evaluation results in changes in diagnosis in many patients. Empiric treatment can delay referral and appropriate treatment.
Utility of DWI with quantitative ADC values in ovarian tumors: a meta-analysis of diagnostic test performance
Authors: Pi Shan , Cao Rong , Qiang Jin Wei , Guo Yan Hui
Published: February 2018

Background

Diffusion-weighted imaging (DWI) and quantitative apparent diffusion coefficient (ADC) values are widely used in the differential diagnosis of ovarian tumors.

Purpose

To assess the diagnostic performance of quantitative ADC values in ovarian tumors.

Material and Methods

PubMed, Embase, the Cochrane Library, and local databases were searched for studies assessing ovarian tumors using quantitative ADC values. We quantitatively analyzed the diagnostic performances for two clinical problems: benign vs. malignant tumors and borderline vs. malignant tumors. We evaluated diagnostic performances by the pooled sensitivity and specificity values and by summary receiver operating characteristic (SROC) curves. Subgroup analyses were used to analyze study heterogeneity.

Results

From the 742 studies identified in the search results, 16 studies met our inclusion criteria. A total of ten studies evaluated malignant vs. benign ovarian tumors and six studies assessed malignant vs. borderline ovarian tumors. Regarding the diagnostic accuracy of quantitative ADC values for distinguishing between malignant and benign ovarian tumors, the pooled sensitivity and specificity values were 0.91 and 0.91, respectively. The area under the SROC curve (AUC) was 0.96. For differentiating borderline from malignant tumors, the pooled sensitivity and specificity values were 0.89 and 0.79, and the AUC was 0.91. The methodological quality of the included studies was moderate.

Conclusion

Quantitative ADC values could serve as useful preoperative markers for predicting the nature of ovarian tumors. Nevertheless, prospective trials focused on standardized imaging parameters are needed to evaluate the clinical value of quantitative ADC values in ovarian tumors.
Aesthetic gestures, moral frameworks: Performing landlessness in Brazil
Authors: Flynn Alex
Published: February 2018

This article, focusing on the Landless Workers’ Movement (MST) of Brazil, demonstrates how members of Latin America’s largest social movement perform the diverse compacts of obligation and reciprocity that characterise an MST occupation. MST encampments seek to enact a transformation of the land on which members are situated, but also emphasise a transformation of the human subject itself, from unproductive to productive. Performing this transformation and becoming truly ‘landless’, however, goes beyond merely being a willing new member: equally as important is the creation and maintenance of an ‘aesthetics of orderliness’ which makes visible the moral connotations that structure or undermine one’s right to become sem terra, landless. Through an analysis that foregrounds the temporality and territoriality of how the MST occupy and drawing a distinction between the precariousness of an MST encampment and the relative stability of an MST settlement, I suggest that movement members are content to perform in the former, but increasingly seek to issue performative acts in the latter. Building on Judith Butler’s distinction between performativity and performance, I argue that individual MST members, embedded in relational spheres, ultimately seek not only to transform themselves but also the wider movement by reconfiguring the very moral framework that structures their social movement from the ground up.
Poly(lactic acid) phase transitions in the presence of nano calcium carbonate: Opposing effect of nanofiller on static and dynamic measurements
Authors: Yousefzade Omid , Jeddi Javad , Vazirinasab Elham , Garmabi Hamid
Published: February 2018

The effect of stearic acid-coated nano calcium carbonate (NCC) on transitions and chain mobility of poly(lactic acid) (PLA) was investigated. Dispersion state of NCC in polymeric matrix was explored using scanning electron microscopy and surface tension component measurements. Trends of PLA transitional phenomena were investigated using the results of dynamical mechanical analysis (DMA) and differential scanning calorimetry (DSC) in the nanocomposite systems based on PLA and NCC. In addition, two types of crystal structures and decreasing the glass transition temperature were distinguished using temperature-modulated DSC (TMDSC). Higher melting points of polymer crystals were found in TMDSC experiments due to low and dynamic heating rate compared to the conventional DSC. Dynamics of polymer chains, affected by NCC, were quantified using cooperativity length, ξ α, and the number of relaxing structural units, Nα, in the glass transition region. NCC particles hindered the cooperative motion of polymer chains at glass transitions and crystallization in TMDSC measurements, whereas the DMA results indicated that NCC particles may act as lubricant and simplified chain mobility.
From Donor to Recipient: Considerations for Blood Transfusion Outcomes Research
Authors: Jones Allison R. , Brown Michelle R. , Vance David E.
Published: February 2018

Donated blood can be broken down into blood components for use in patient care. This article focuses primarily on packed red blood cells (PRBCs), as they experience breakdown during storage that may adversely impact patient outcomes. Patients require PRBC transfusions for a number of clinical reasons. Although transfusions of PRBCs provide some clinical benefit, they are also associated with increased morbidity and mortality across multiple patient populations, albeit the mechanisms underlying this relationship remain unclear. With an aging, more acutely ill population requiring aggressive treatment and a lack of transfusion alternatives, research focused on PRBCs has gained momentum. Proper interpretation of research findings on the part of clinicians depends on accurate data collection that includes aspects of both the transfused blood components and the recipients. The purpose of this article is to examine stored PRBC factors, blood-donor characteristics, transfusion-specific factors, and patient-specific characteristics as they relate to patient outcomes research. Challenges associated with performing and interpreting outcomes of transfusion-related research are presented. Implications of current evidence for patient care, such as awareness of benefits as well as risks associated with blood component transfusion, are also provided.
Symptom Science: Omics Supports Common Biological Underpinnings Across Symptoms
Authors: McCall Maura K. , Stanfill Ansley Grimes , Skrovanek Elizabeth , Pforr Jessica Renee , Wesmiller Susan W. , Conley Yvette P.
Published: February 2018

For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar symptoms (sleep disruption, cognitive impairment, fatigue, gastrointestinal [GI] distress, and pain) to identify genes associated with the symptom or symptoms across disease processes. The review yielded 27 genes associated with more than one symptom. ABCB1 (MDR1), APOE, BDNF, CNR1, COMT, DAT1 (SLC6A3), DRD4, ESR1, HLA-DRB1, IL10, IL1B, IL6, LTA, PTGS2 (COX-2), SLC6A4, and TNF were associated with cognitive impairment and pain, which had the most genes in common. COMT and TNF were related to all symptoms except sleep disruption. IL1B was associated with all symptoms except cognitive impairment. IL10, IL1A, IL1B, IL1RN, IL6, and IL8 (CXCL8) were linked with all the exemplar symptoms in various combinations. ABCB1 (MDR1) and SLC6A4 were associated with cognitive impairment, GI distress, and pain. IL10 and IL6 were linked to cognitive impairment, fatigue, and pain. APOE and BDNF were associated with sleep disruption, cognitive impairment, and pain. The 27 genes were associated with canonical pathways including immune, inflammatory, and cell signaling. The pathway analysis generated a 15-gene model from the 27 as well as 3 networks, which incorporated new candidate genes. The findings support the hypothesis of overlapping biological underpinnings across the exemplar symptoms. Candidate genes may be targeted in future omics research to identify mechanisms of co-occurring symptoms for potential precision treatments.
Effects of Gender-Specific Differences, Inflammatory Response, and Genetic Variation on the Associations Among Depressive Symptoms and the Risk of Major Adverse Coronary Events in Patients With Acute Coronary Syndrome
Authors: Sanner Jennifer , Grove Megan L. , Yu Erica , Moeller F. Gerard , Cron Stanley G. , Boerwinkle Eric , Morrison Alanna C. , Frazier Lorraine
Published: February 2018

Depressive symptoms independently contribute to major adverse coronary events (MACEs), with the biological immune response to depression being a likely mediator of this relationship. To determine whether genetic- and/or gender-specific phenotypic differences contribute to associations among depressive symptoms, inflammatory response, and risk of MACE in patients with acute coronary syndrome (ACS), we conducted a prospective study of 1,117 ACS patients to test a gender-specific model in which depressive symptoms (Beck Depression Inventory-II [BDI-II]) are associated with risk of MACE. Cox proportional hazards models were used to model time to incident MACE and determine whether single-nucleotide polymorphisms (SNPs) in specific inflammatory protein-coding genes and depressive symptoms interact to influence levels of inflammatory proteins or risk of MACE. Females had significantly higher high-sensitivity C-reactive protein and monocyte chemoattractant protein-1 levels. Depression status differed by gender (29.9% of females and 21.1% of males had BDI-II scores indicative of depression [ p = .0014]). Depressive symptoms were associated with MACE; however, the interaction between these symptoms and gender was not significant. SNPs and depressive symptoms did not interact to influence inflammation or MACE. More females than males had BDI-II scores indicative of depression, yet the association between positive depressive symptom status and MACE did not vary by gender. Nor did the SNPs interact with depressive symptoms to influence inflammation or MACE. It remains of interest to identify a high-risk subgroup of ACS patients with genetic polymorphisms that result in immunoinflammatory dysregulation in the presence of depressive symptoms.