bluuebunny/crossref_metadata_2025 huggingface dataset:
Usp18 Expression in CD169+ Macrophages is Important for Strong Immune Response after Vaccination with VSV-EBOV
Authors: Friedrich Sarah-Kim , Schmitz Rosa , Bergerhausen Michael , Lang Judith , Cham Lamin B. , Duhan Vikas , Häussinger Dieter , Hardt Cornelia , Addo Marylyn , Prinz Marco , Asano Kenichi , Lang Philipp Alexander , Lang Karl Sebastian
Published: March 2020

Ebola virus epidemics can be effectively limited by the VSV-EBOV vaccine (Ervebo) due to its rapid protection abilities; however, side effects prevent the broad use of VSV-EBOV as vaccine. Mechanisms explaining the efficient immune activation after single injection with the VSV-EBOV vaccine remain mainly unknown. Here, using the clinically available VSV-EBOV vaccine (Ervebo), we show that the cell-intrinsic expression of the interferon-inhibitor Usp18 in CD169+ macrophages is one important factor modulating the anti-Ebola virus immune response. The absence of Usp18 in CD169+ macrophages led to the reduced local replication of VSV-EBOV followed by a diminished innate as well as adaptive immune response. In line, CD169-Cre+/ki x Usp18fl/fl mice showed reduced innate and adaptive immune responses against the VSV wildtype strain and died quickly after infection, suggesting that a lack of Usp18 makes mice more susceptible to the side effects of the VSV vector. In conclusion, our study shows that Usp18 expression in CD169+ macrophages is one important surrogate marker for effective vaccination against VSV-EBOV, and probably other VSV-based vaccines also.
Vaccination with Consensus H7 Elicits Broadly Reactive and Protective Antibodies against Eurasian and North American Lineage H7 Viruses
Authors: Fadlallah Gendeal M. , Ma Fuying , Zhang Zherui , Hao Mengchan , Hu Juefu , Li Mingxin , Liu Haizhou , Liang Biling , Yao Yanfeng , Gong Rui , Zhang Bo , Liu Di , Chen Jianjun
Published: March 2020

H7 subtype avian influenza viruses have caused outbreaks in poultry, and even human infection, for decades in both Eurasia and North America. Although effective vaccines offer the best protection against avian influenza viruses, antigenically distinct Eurasian and North American lineage subtype H7 viruses require the development of cross-protective vaccine candidates. In this study, a methodology called computationally optimized broadly reactive antigen (COBRA) was used to develop four consensus H7 antigens (CH7-22, CH7-24, CH7-26, and CH7-28). In vitro experiments confirmed the binding of monoclonal antibodies to the head and stem domains of cell surface-expressed consensus HAs, indicating display of their antigenicity. Immunization with DNA vaccines encoding the four antigens was evaluated in a mouse model. Broadly reactive antibodies against H7 viruses from Eurasian and North American lineages were elicited and detected by binding, inhibition, and neutralizing analyses. Further infection with Eurasian H7N9 and North American H7N3 virus strains confirmed that CH7-22 and CH7-24 conferred the most effective protection against hetero-lethal challenge. Our data showed that the consensus H7 vaccines elicit a broadly reactive, protective response against Eurasian and North American lineage H7 viruses, which are suitable for development against other zoonotic influenza viruses.
Variaciones de las políticas de cooperación Sur-Sur en América Latina. Estudios de casos.
Authors: Malacalza Bernabé
Published: March 2020

La trayectoria de la cooperación Sur-Sur para el desarrollo (CSSD) de América Latina presenta altibajos, con ciclos de auge, retracción y estancamiento. Los vaivenes se deben a factores estructurales y de agencia, tales como la crisis de la globalización, las diversas coyunturas políticas y económicas internacionales y re- gionales, las agendas de los donantes del Comité de Ayuda al Desarrollo (CAD) de la Organización para la Cooperación y el Desarrollo Económicos (OCDE), así como a las vulnerabilidades y giros de las políticas de cooperación latinoamericanas. El presente estudio analiza las continuidades y cambios de las políticas de CSSD de Argentina, Brasil, Chile, Colombia, Costa Rica, Cuba, Ecuador, México, Perú, Uruguay y Ve- nezuela desde 2015. Serán abordados discursos, planes nacionales de desarrollo, estrategias-país o linea- mientos de política, asignación geográfica y sectorial de iniciativas y modelos institucionales. En cada caso serán apuntados los dilemas políticos que determinan las principales trabas que obstaculizan que la CSSD opere como motor de cambio internacional y desarrollo sostenible.
Production’s digital transformation analysis using Industry 4.0 technologies
Authors: Novikov Sergey V. , Sazonov Andrey A.
Published: March 2020

The article is devoted to a detailed analysis of the industry’s digital transformation processes based on the use of Industry 4.0 technologies. The theoretical analysis made it possible to establish that technological trends are often in the spotlight, however, the need for transformation is not posed by technology as such, but by deep shifts in the enterprise’s external environment caused by digitalization. The study of industry transformation global mechanisms allowed the article’s authors to identify eight key levers necessary for creating value due to the Industry 4.0 technologies implementation at a high-tech production. In conclusion, the authors consider the technological transformation process in Russia, as well as the main directions that can effectively accelerate it.
The problems of reproduction of traditional culture in Russian regions in the XX century on the example of the Kirov region
Authors: Trushkova Irina Yuryevna , Titova Elena Ivanovna , Sapozhnikova Vera Viktorovna
Published: March 2020

Combinatorics of industrial and post-industrial processes are manifested differently in different countries and regions of the world. Ethnographic / anthropological research reveals their focus, speed, territorial specificity. The purpose of the work is the study of life support systems, the reproduction of ethnic cultures, which is relevant today due to problems with natural resources, environmental pollution, increased stress in everyday life, a decrease in the ecology of life, immunity, etc. The methodology is based on the methods of ethnographic expeditions, ethnomonitoring in specific Russian territory (the Vyatka province in the past, the Kirov region - now). For several decades, patterns have been identified and formulas for consolidating industrial and post-industrial changes in the 20th - early 21st centuries have been presented. Results. There is a change in the types of settlements, from the location and size in the cultural landscape. The structure of the settlement was changing, new, industrial facilities — new socio-political institutions, complicated production — were “implanted” in them.  Ethnoeconomics, along with industrial elements, continued to maintain traditional, peasant household occupations, which served as an aid in crises. Cultural inversions were also observed in the use of clothing, utensils, and the food system. The mainstay of the life support system was health conservation. It included a balance of physical labor and rest, disease prevention, herbal medicine, maintaining immunity and stress prevention. The spiritual abandonment of ethnic cultures during the Soviet time has undergone a maximum of changes. Religious holidays were forbidden, part of the Orthodox and Muslim rites was reproduced secretly, ethnopedagogy was partially preserved only at home. New communication expanded in communities, names, communication style and relationships. Ethnomonitoring in such Russian regions as the Kirov region demonstrates the non-linearity of the change of the agrarian to the industrial and post-industrial era, and their parallel co-existence in crises shows cultural inversions. Such adjustments to common theories can increase efficiency in managing the economy and socio-political life of these complex territories.
Entrepreneurship in national economics: significance and potential of development
Authors: Pinkovetskaia I. S. , Aleksandrova N. R. , Mingazova O. N.
Published: March 2020

The purpose of the study was to develop proposals for the use of two comprehensive indexes to assess the social significance and the existing potential for entrepreneurship development in different countries. The study used information provided in the report on the Global entrepreneurship monitoring project. At the same time, the opinions of residents of 48 countries for 2018 were considered. The first index included four indicators, and the second index included five indicators. Mathematical models were developed and the values of these two complex indexes were calculated. The average values of the indexes and their ranges of change for most countries are determined. Lists of countries with high and low index values are given. A comparative analysis of the values of complex indexes typical for Russia and other countries is presented. The results of research are new and original, have scientific and practical significance.
Information and Communication Technologies of Teaching Higher Mathematics To Students of Engineering Specialties At Technical Universities
Authors: Terekhova Natalya Vladimirovna , Zubova Elena Aleksandrovna
Published: March 2020

Excessive anthropogenic pressure on land resources in Ukraine leads to a deterioration of their quality, and consequently they lose their potential. Human impact on the change of land quality can be direct (by involving land lots in use, carrying out economic activities) and indirect (as a result of such activity, enhancing the natural degradation of soils). The tendency of deterioration of the state of land resources requires the subordination of land relations to the main goal – to ensure comprehensive protection of this major national wealth of Ukraine.
Legal support for the protection of agricultural land is considered as a single complex of interdependent elements: legal standards for the protection of land, soil, agricultural landscapes, and the mechanism for their implementation – legally significant measures: economic, organizational, scientific and technical. At the same time, it was concluded that the system of legal regulation of the use of agricultural land is not sufficiently saturated with mechanisms for regulating agricultural activity.
A STUDY ON THE VARIATION IN CA 72-4 LEVELS OF THE GASTRIC CANCER’S PATIENTS BEFORE AND AFTER SURGERY TREATMENT
Authors: Hoang Thi Thu Huong , Nguyen Minh Vuong
Published: March 2020

Objectives: Studying on the variation in CA 72-4 levels of the gastric cancer’s patients before and after 10 days and 30 days surgery treatment. Materials and methods: The studying group included 42 gastric cancer’s patients who were examinated and treated in cancerology service of Hue University Hospital and gastroenterology service of Hue Central Hospital. The control group included 30 healthy normal examinated at Hue University Hospital. The study groups were clinical, endoscopic anatopathologic examination diagnosed with gastric cancer and quantitative levels of CA 72-4 in three times points: before surgerying, after surgerying 10 days and 30 days postoperatively. Rerults: The concentration of CA 72-4 in gastric cancer’s patients was 10.06 ± 16.49 U/ml. Clearly higher than the control group 1.2 ± 0.4 U/ml(p <0.01). The rate increased levels of CA 72-4 in gastric cancer’s patients before surgerying was 27.5% and the control group was 0%. After 10 days of surgery, CA 72-4 level was 5.56 ± 8.55 U/ml; 82.5% of patients have reduced levels of CA 72-4 and 17.5% no changes; there are 0% increased cases. After 30 days of surgery, CA 72-4 level was 3.79 ± 6,52 U/ml. CA 72-4 level 10 days after surgering have decreased significantly compared to before surgery (p < 0.05) and 30 days after surgery have decreased significantly compared to after 10 days (p < 0.05). 30 days postoperatively, 90% patients had reduced levels of CA 72-4, 10% no changes, no patient had increased levels of CA 72-4 and no patient be relapsed after 30 days of treatment. Conclusions: CA 72-4 concentrations before surgerying increased 27.5%, after surgery 10 days and 30 days reduced step by step, no case have increased CA 72-4 levels, no case relapsed after 30 days.
AN ULTRASOUND SURVEY ON THE PLACENTA AND AMNIOTIC CHARACTERISTICS IN THE SINGLE POSTTERM PREGNANCY
Authors: Ha Thi My Dung , Cao Ngoc Thanh , Tran Thi Song Huong
Published: March 2020

Objective: To characterize ultrasound images of placenta and amniotic fluid in cases of singleton pregnancies beyond term predictions, and also explore the relationship between placenta, amniotic fluid and labor transfer status, postpartum child status. Image properties of prenatal placenta and amniotic fluid are immediately examined with ultrasound in 267 cases of postterm pregnancy beyond prediction at Obstetric Department, Hue Central Hospital. Results: In postterm pregnancy, placenta thickness decreases gradually according to gestational age. Oligohydramnios is 30.3%. There is a correlation between amniotic fluid index and birth method with r = 0.41. Sensitivity is 89.15%. Specificity is 48.55%. There is also a correlation between amniotic fluid echogenicity and method of birth: r = 0.478. Sensitivity is 97.67%. Specificity is 42.75%. Amniotic fluid index and baby Clifford's syndrome are also relevant, with r=0.466. Sensitivity is 83.78%. Specificity is 78.26%. Conclusions: Ultrasound scanning of amniotic fluid properties should be noted in the case of postterm pregnancy.
QUANTITATIVE ANALYSIS OF BETULINIC ACID IN THE PLANT TETRACERA SCANDENS USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: Nguyen Thi Hoai
Published: March 2020

Objective: Betulinic acid is a compound that has many valuable biological activity, the determination of betulinic acid in Tetracera scandens (Dilleniaceae) makes accommodate the exploitation of medicinal will be used in the future. Materials and method: Tetracera scandens had been collected in Huong Thuy District - Thua Thien Hue Province. The quantification were made by a HPLC system using a C18 column. Results: From species Tetracera scandens collected at Huong Thuy - Thua Thien Hue, by a HPLC system, UV-VIS detector, the result showed that accumulation of the principle compound in the aerial parts of the plant is 1.069%.
EVALUATION OF RESULTS OF THE PROSTHODONTICS ON THE DENTAL IMPLANTS AT HUE UNIVERSITY HOSPITAL
Authors: Tran Thanh Phuoc , Nguyen Toai , Le Hong Lien , et al
Published: March 2020

Objective: Implant is made ​​of titanium fixture implanted into the jawbone to replace lost teeth, allows for recovery of function and aesthetics. In Vietnam, dental implant has become a popular technique in the Odonto-stomatology Hospital since 10 years ago. Since January 2009, dental implant has been made for patients at the Dentistry Clinic, Hue University Hospital. The purpose of this study is to evaluate the effectiveness of the prosthodontics on implant. Subjects and method: The study consisted of 34 patients with 53 fixtures have been implanted. The patients were located periodontal healing and prosthodontics on implant after 2-3 weeks. Evaluation results for the next one week, after 6 months according to the criteria. Result: The effect of prosthodontics on implant after 1 week: 90.57% achieved good, only 9.43% to the average. After 6 months: 96.97% achieved good, average 3.03%, no bad results. Conclusion: The above results demonstrate the effectiveness of dental implants to restore function and aesthetics for people with missing teeth.
STUDY ON THE CORRELATION BETWEEN PLASMA NT-PROBNP CONCENTRATION AND STRUCTURAL CHANGE AND DYSFUNCTION OF LEFT VENTRICLE IN DIABETIC TYPE 2 PATIENTS
Authors: Nguyen Hai Thuy , Le Thanh Tung
Published: March 2020

Objectives: 1.To measure plasma NT- proBNP levels, shape and function of left ventricle of diabetic type 2 patients, and (2) To explore the correlation between plasma NT-proBNP levels and the shape and function of the left ventricle, and heart failure according to Framingham, NYHA, and ACC/AHA criteria. Materials and Methods: Cross-sectional and descriptive study on 104 diabetic type 2 patients through the measurements of plasma NT-proBNP levels, ECG and Doppler echocardiography. Results: Average plasma NT-proBNP level: 142.17 ± 186.95 pg/ml. The results highlighted that: (1) Plasma NT-proBNP level significantly increases with age, the detection time, the severity of clinical heart failure, left ventricle hypertrophy, and diastolic-systolic dysfunction of left ventricle (p <0.05), and (2) Plasma NT-proBNP level significantly correlates with heart failure based on Framingham criteria (r = 0.66; p < 0.001), functional heart failure based on NYHA classification (r = 0.676; p < 0.001), the stage of heart failure based on the ACC/AHA guidelines (r = 0.709; p < 0.001), left ventricle hypertrophy based on Sokolow-Lyon (r = 0.346; QTc (r = 0.471; p < 0.001), LVMI (r = 0,701; p < 0,001), diastolic dysfunction grades (r = 0.604; p < 0.001), DTE (r = 0.437; p < 0.001), IVRT (r = 0.29; p = 0.003), EF (r = - 0.414; p < 0.001), and systolic dysfunction grades (r = 0.502; p < 0.001). Conclusion : At the cut-point of 125 pg/ml, plasma NT-proBNP level has the prognostic value of left ventricle hypertrophy, and diastolic-systolic dysfunction of left ventricle in diabetic type 2 patients.
ANTI-CANCER COMPOUNDS ISOLATED FROM SOFT CORAL SINULARIA CRUCIATA - ALCYONIIDAE
Authors: Vo Quoc Hung , Doan Nguyen Phuong Nhi , Nguyen Dinh Quynh Phu , Ho Thi Dieu Tram , Nguyen Thi Hoai
Published: March 2020

Objectives: Nowadays, bioactive substances isolated from marine organisms which are abundant and varied in Vietnamese sea attracted more and more the attention of scientists in the world and Vietnam as well. We have studied on soft coral Sinularia cruciata – Alcyoniidae, which has never been studied in Vietnam before, to find substances which are useful in medical field, especially in anti-cancer therapy. Materials and method: Specimens of soft coral Sinularia cruciata were collected from Con Co, Quang Tri province in May 2011. Pure compounds were isolated by using Thin Layer Chromatography; Column Chromatography normal phase and inverse phase; Shephadex LH 20. Structures of them were determined by spectral data of Nuclear Magnetic Resonance (NMR), Electrospray Ionization Mass Spectrometry (ESI-MS). Results & Conclusion: Structures of 4 compounds were identified: (1) 5.8-epidioxycholest-6-en-3-ol (2) Cholesterol (3) 1-O-hexadecyl-glycerol (Chimyl alcohol) (4) Glycerol 1-O-octadecyl ether (Batyl alcohol). The substance (1) was demonstrated to have strong anti-cancer effects in previous study. Key words Sinularia cruciata, Alcyoniidae, 5,8-epidioxycholest-6-en-3-ol, soft coral, cancer.
DESIGN AN “IN-HOUSE” SOFTWARE FOR CALCULTING THE RISK OF TRISOMY 21 AND OPEN NEURAL TUBE DEFECTS IN THE GESTATIONAL AGE 15 – 22 WEEKS
Authors: Le Phan Tuong Quynh , Nguyen Viet Nhan
Published: March 2020

Objectives: Design an “in-house” software for calculating the risk of fetus has Down syndrome, Edwards syndrome and open neural tube defects in prenatal screening at the gestational age 15-22. Methods: Based on the Excel program of Microsoft Office and the articles with the Excel of Microsoft Office and the related articles have been published. Results: In cases have the risk of trisomy 21 with the range from 1/251 to 1/350: the risk tends to be lower than Prisca (83.7%). In cases have the high risks of trisomy 21 in screening but the results of prenatal diagnosis are not trisomy: the risks of “in house” software are lower than the risks of Prisca (73%) with 29% of cases has the risks less than 1/250. In cases of trisomy 18 with the risks are lower than 1/150: there are statistical significant differences between the two softwares (P <0.05). In screening open neural tube defects, the cases have the threshold higher than 1.50 MoM AFP: The results in the “in house” software tend to higher than Prisca (94%). The cases have the threshold lower than 1.50 MoM AFP: Where the disability screening of neural tube openings with thresholds lower than 1.5 MoM AFP: there are no statistical significant differences between the two softwares (P >0.05). Conclusion: The “in house” software has all the necessary functions for calculating the risk of Down syndrome, Edwards syndrome and open neural tube at the gestational age 15-22.
EVALUATION OF PATIENT FEATURES AND CLINICAL OUTCOMES IN PARTIAL EDENTULOUS PATIENTS SUFFERING IMPLANT SURGERY
Authors: Nguyen Van Minh , Nguyen Toai , Tran Thanh Phuoc
Published: March 2020

Background: Dental implants have been used to restore teeth loss in Thua Thien Hue province. However, no study reports on the outcome of using implants for this purpose. The aim of this study was evaluated the patient features and clinical outcome in partial edentulous patients suffering implant surgery. Materials and methods: 34 patients treated with 62 implants Mis from 01/01/2009 to 30/12/2010 were prospective analyzed with regard to implant success after 3 to 6 months follow-up. Results: Patients are mostly female patients, the most common age group is 18-39. Tooth loss is often mandibular first molars, mainly due to caries. Without significant complications occurred in the course of surgery, good initial stability accounts for 96.77%. After follow-up periods of 3 to 6 months, good osseointegration is 93.55%. Conclusions: Dental implant surgery is highly successful treatment, restores funtions and esthetics for patients with tooth loss.
EVALUATE THE EFFECTIVENESS OF PARTIALLY EDENTULOUS PATIENT WITH FIXED CERAMIC PROSTHODONTICS
Authors: Tran Thi My Lan
Published: March 2020

Background: With the higher development of our society, nowadays people more and more care about their oral problems. Ceramic fixed prosthodontics is the first solution which people choose to satisfy them both the esthetics and function.
Materials and Methods: The method is clinical progress treated on 50 patients who want to make ceramic prosthodontics at the Faculty of Odonto – Stomalogy, Hue University of Medicine and Pharmacy and the Departement of Odonto – Stomalogy, Hue Central Hospital from March 2010 to April 2011.
Results: After fixing: color of crown: 82.27% good, 17.73% rather, shape of crown: 88.61% good, 11.39% rather. After fixing 3 months: color of crown: 88% patients evaluate well. Shape of crown: 90% patients evaluate well.
Conclusion: 94% patients feel fixed ceramic prosthodontics satisfy them both the esthectics and function.
THE SERUM CONCENTRATIONS LEVEL OF CK, CK-MB AND CARDIAC TROPONIN T IN EARLY NEONATES WITH ASPHYXIA
Authors: Nguyen Ngoc Minh Chau , Phan Hung Viet
Published: March 2020

Objective: Investigate the change of serum Creatine kinase (CK), CK-MB and cardiac troponin T concentrations in early neonates with asphyxia. The relation between the change of serum Creatine kinase (CK), CK-MB and cardiac troponin T concentrations and degree of asphyxia. The serum CK, CK-MB and cardiac troponin T concentrations of asphyxiated newborn were measured in the first 24 hours after admission.
Material and methods: Patients: 27 early asphyxiated neonates with apgar mark at 5 minutes from 0-7.Study site: Neonatal of Pediatric department, Hue central hospital. Methods: Prospective, description study.
Results: Asphyxiated neonates had significantly higher concentration of CK, CK-MB and Troponin T than controls: mean CK 1146.7±711.7U/L vs 145.6±26.4, p<0.01; mean CK-MB 22.15±13.78ng/ml vs 2.77±1.08, p<0.01; mean Troponin T 0.099±0.08ng/ml vs ≤0.01, p<0.05. The serum CK, CK-MB and cardiac troponin T concentrations increased significantly with severity of asphyxia.
Conclusion: There is an increase in CK, CK-MB and Troponin T levels in neonates with asphyxia. Correlation with statistical significance between the concentration of CK, CK-MB and troponin T with severity of asphyxia.
THE ROLE OF NT-PROBNP IN DIABETIC PATIENTS
Authors: Tran Viet An , Tran Huu Dang
Published: March 2020

Background: Moist Heat Sterilization validation process comprises several steps. The IQ, OQ have to follow the specified SOPs of manufacturer or equipment supplier. However, the efficiency of the sterilization process must be expressed in numberized values based on sterilization coefficient D, Z value, F value and SAL value. Materials and methods: Studying to calculate the total Moist Heat Sterilization time based on the survey results process validation at 13 pharmaceutical factories having chains of sterile drugs and the other published documents. Results: The researched results were calculated the total sterilization time C (if the assumption that SAL = 10-6), this time will be compared with the real time of the process. Conclusion: The real time of the sterilization process is as similar as the C value, the efficiency of sterilization process is highlier. Keywords: Sterile drug, Moist Heat Sterilization, D value, Z value, F value, Biological indicator, process validation.
A STUDY OF HYPOGLYCEMIA IN EARLY NEONATAL PERIOD AT PEDIATRIC SERVICE IN HUE UNIVERSITY HOSPITAL
Authors: Nguyen Thi Kieu Nhi
Published: March 2020

Objectives: 1. To describe prevalence of hypoglycemia according to neonatal classification and early neonatal 2. To define the relation between early neonatal hypoglycemia with neonatal classification and early neonatal diseases. Materials and method: Pathological newborns of 1- 7 days after birth transfered from Maternity to Neonatal Unit of Hue University Hospital for illness after immediate resuscitation at Delivery Room or not well beside mother in rooms at maternity. These babies were be checked glucose test at hospitalization from 1st May, 2009 to 31st May, 2010 (12 months). Case – control longitudinal study. Results: Highest prevalence of hypoglycemia was in premarures < 37 W (36.59%), then post-mature (19.78%) and lowest in term babies 38-42 W (10.42%). Prevalence of hypoglycemia was highest in large birth weight proportional to gestational age (50%), low birth weight (65.4%); and lowest in proportional birth weight (14.29%). Hypoglycemia occured on early neonatal infection (23.31%), asphyxia (15.38%), respiratory distress without neonatal infection (10%), congenital malformation (6.67%). Risk factors identified as prematures < 37 W (OR = 3.2767; p<0.01); large birth weigh (OR = 4.7368; p<0.05); low birth weight (OR = 4.2857; p<0.05); early neonatal infection (OR = 2.6057; p<0.05). Conclusion: It is necessary to classify newborns according to gestational age and birth weight for screening hypoglycemia as soon as possible during care of premature < 37 W, large birth weight, low birth weight, early neonatal infection.
EXTRACTING THE CAUSE-EFFECT RELATIONSHIPS FROM FORMULATION DATA OF CONTROLLED RELEASE PRODUCT USING VISUALISATION METHOD
Authors: Do Quang Duong
Published: March 2020

Background: The study of examining the influence of ingredients to the properties of the product especially the release of active ingredients is regular job and is very important. This paper presents a method to support surveying the cause-effect relationships from experimental data of controlled release tablet formulation with an intuitive method - parallel coordinates. Materials and methods: In the survey of cause-effect relationships, the experimental data of tablets controlled release formulation referenced from a published article and parallel techniques will be applied to extracting the intuitive relationships between the variables of ingredients and properties. Results: With the parallel coordinates technique combined to neural network for modeling formulation data, the formulator can manipulate to change the value of independent variable X by selecting the values ​​to be examined to see the change of the dependent variable Y. Compared with the predicted quadratic form from the published result, parallel coordinates view has taken the cause and effect relationship and a more accurate visualisation. Conclusion: This result will lead formulators to understanding their products more precisely and saving a lot of time and labor in R&D process. Keywords: neural networks, visualisation, cause-effect relationships, controlled release
Key words: neural networks, visualisation, cause-effect relationships, controlled release
UPDATE ON PHARMACOLOGICAL THERAPY OF NAUSEA AND VOMITTING
Authors: Le Chuyen , Tran Van Huy
Published: March 2020

Vomiting is a very common symptom in some clinical gastrointestinal diseases, after cancer chemotherapy, surgery, pregnancy, infections,...Taking anti-nausea medication without doctor's prescription or improper doctor's prescription can lead to missed or hide the symptoms of some serious disease or unwanted effects of antiemetics that are very common and very complexity. Therefore, the indication of anti-nausea medication is not as simple as many people think, but need to have exactly indication after determining the cause and mechanism of vomiting, or after excluding dangerous diseases that vomiting just symptoms, especially in cases such as pregnant women and breastfeeding mothers, patients with radiotherapy or chemotherapy for cancer. Now there are many treatments for vomiting applying in recent times such as anti-Neurokinin receptors (NK1), corticosteroids (dexamethasone),...be seen as an effective anti-nausea therapy. The appropriate selection of each drug or treatment methods to specific cases as indication will be effective and safe treatment.
MANİSA’DA 5-14 YAŞ ARASI ÇOCUKLARDA ENÜREZİS NOKTURNA SIKLIĞI VE İLİŞKİLİ FAKTÖRLER
Authors: BİLGİN ŞAHİN Berna , ERBAY DÜNDAR Pınar
Published: March 2020

Amaç: Manisa’da seçilen kentsel ve
yarı-kentsel iki bölgede 5-14 yaş çocuklarda enürezis nokturna (EN) prevalansı
ve etkili risk faktörlerinin belirlenmesidir.

Gereç ve Yöntem: Araştırmanın evreni
Manisa’da kentsel ve yarıkentsel iki aile sağlığı merkezi bölgesinden 2674
çocuktur. Araştırmada küme örneklem
yöntemi kullanılmış, %15 beklenen prevalans, %95 güven sınırında %5 sapma ve
1.5 desen etkisi ile 274 kişiye ulaşılması gerektiği hesaplanmış ve 300 kişi
hedeflenmiştir. Katılım oranı %93.6’dır (n=281). Araştırmanın bağımlı değişkeni
EN, bağımsız değişkenleri sosyodemografik özellikler, aile öyküsü, tuvalet
eğitim yaşı/biçimi, EN ile ilgili olduğu düşünülen sağlık sorunları, anne ve
çocuğun duruma yaklaşımıdır. Veriler yüzyüze görüşme tekniği ile çocukların
evlerinde annelerinden toplanmıştır. Veri analizinde ki kare, Student’s t testi
ve lojistik regresyon modeli uygulanmıştır. Tüm analizlerde p<0.05
istatistiksel olarak anlamlı kabul edilmiştir.

Bulgular: EN prevalansı %14.9’dur. Tek
değişkenli analizde bölge, yaş, odada yalnız yatmama, tuvalet eğitiminde ve
çocuğu uyandırmakta zorlanma, konstipasyon, enkoprezis, ıkınarak işeme, idrar
tutma alışkanlığı, dikkat eksikliği/hiperaktivite/tırnak yeme alışkanlığı,
babada EN öyküsü EN ile ilişkili bulunmuştur. Anne/baba eğitimi ve baba mesleğinin
niteliği azaldıkça, günlük sıvı alımı arttıkça prevalans artmıştır. Anlamlı
değişkenlerle kurulan lojistik regresyon modelinde babada EN öyküsü
5.66(GA1.97- 16.27), enkoprezis varlığı 5.26(GA1.23-22.53) annelerin tuvalet
eğitimi verirken zorlanması 5.35(GA1.95-14.64) kat EN riskini artırmaktadır. EN
tanısı alan çocukların %28.6’sı tedavi almaktadır ve tedavi almayanların
annelerinin %60.0’ı bu durumu normal karşılamaktadır.

Sonuç: : EN sıklığı %14.9’dur. EN ile ilişkili değişkenler; babada EN öyküsü,
enkoprezis ve annelerin tuvalet eğitimi verirken zorlanmasıdır.
Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections
Authors: Xiu Weijun , Gan Siyu , Wen Qirui , Qiu Qiu , Dai Sulai , Dong Heng , Li Qiang , Yuwen Lihui , Weng Lixing , Teng Zhaogang , Mou Yongbin , Wang Lianhui
Published: March 2020

The formation of bacterial biofilms closely associates with infectious diseases. Until now, precise diagnosis and effective treatment of bacterial biofilm infections are still in great need. Herein, a novel multifunctional theranostic nanoplatform based on MnO
2
nanosheets (MnO
2
NSs) has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy (aPDT) of bacterial biofilm infections. In this study, MnO
2
NSs were modified with bovine serum albumin (BSA) and polyethylene glycol (PEG) and then loaded with chlorin e6 (Ce6) as photosensitizer to form MnO
2
-BSA/PEG-Ce6 nanosheets (MBP-Ce6 NSs). After being delivered into the bacterial biofilm-infected tissues, the MBP-Ce6 NSs could be decomposed in acidic biofilm microenvironment and release Ce6 with Mn
2+
, which subsequently activate both fluorescence (FL) and magnetic resonance (MR) signals for effective dual-mode FL/MR imaging of bacterial biofilm infections. Meanwhile, MnO
2
could catalyze the decomposing of H
2
O
2
in biofilm-infected tissues into O
2
and relieve the hypoxic condition of biofilm, which significantly enhances the efficacy of aPDT. An
in vitro
study showed that MBP-Ce6 NSs could significantly reduce the number of methicillin-resistant S
taphylococcus aureus
(MRSA) in biofilms after 635 nm laser irradiation. Guided by FL/MR imaging, MRSA biofilm-infected mice can be efficiently treated by MBP-Ce6 NSs-based aPDT. Overall, MBP-Ce6 NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm, which provides a promising theranostic nanoplatform for bacterial biofilm infections.
Visión Histórica de la Gerencia: desde la perspectiva universitaria para la Atención de los Adultos Mayores
Authors: Bueno-Medina Aurié del Valle
Published: March 2020

El presente artículo tuvo como propósito la revisión sobre la visión histórica de la Gerencia, permitiendo así la construcción de los momentos representativos que aportaron a esta ciencia, trayendo consigo aportes científicos y humanos en aras satisfacer las demandas contextuales a través del mundo complejo de las organizaciones. Además, la reflexión de hoy en día supone la episteme del cambio donde se pudieran vislumbrar las organizaciones universitarias cuya formación esté dirigida a la gerontología y cómo ésta trasciende el sentido del conocimiento hacia la contribución social para los adultos mayores por medio de las prácticas gerenciales de este tipo de organización.
Rol del profesional de enfermería en la educación para el autocuidado en pacientes con diábetes tipo II
Authors: Cedeño-Holguin Dolores Mirella , Macias-Alvia Aida Monserrate , Batista-Ramírez Reisey , Mejía-Valdez Yadira
Published: March 2020

Son los profesionales de la enfermería, los  expertos en las estrategias relacionadas con el cuidado individual, familiar y grupal y el profesional con mayor cualificación en lo que se refiere a disponer de herramientas específicas sobre metodología persuasiva, educativa y participativa y por tanto , para plantear y dirigir las estrategias de autocuidados en  pacientes con diabetes tipo II. A partir de ello en este artículo se caracterizó el rol del profesional de enfermería en la educación para el autocuidado, a través de una metodologia de tipo documental y con un diseño bibliográfico. El corpus de la investigación estuvo constituido por aspectos teóricos relacionados con el rol de la enfermería en la educación para el autocuidado.  Los resultados del análisis hermenéutico permitieron deducir que el personal de la enfermería debe  mantener un sistema de atención basado en un modelo participativo, en el que los pacientes expresen sus opiniones sobre su enfermedad y decidan sobre las alternativas disponibles a seguir.
Los programas nacionales de formación una política educativa para la transformación social de la salud
Authors: Romero de Jaimes Sandra C
Published: March 2020

La educación como derecho fundamental de todo ser humano permite el desarrollo como ciudadano para lograr una calidad de vida. Esta debe responder a las exigencias del mundo de hoy, en donde las instituciones universitarias asumen una misión que les lleva a revaluar sus funciones y su pertinencia social con el momento histórico. El objetivo de esta investigación fue analizar a través de una metodología documental los Programas Nacionales de Formación como política educativa para la transformación social de la salud. Se concluyó que las universidades a través de los Programas Nacionales de Formación del área de la salud responden a las necesidades que se plantean en el Sistema Nacional de Salud formando profesionales con calidad educativa y con responsabilidad social, para una sociedad más humanizada, en el desarrollo individual y colectivo. Alcanzar el progreso de forma sostenible y sustentable atendiendo los derechos  fundamentales de la salud para la prevención de enfermedades.
En el interior de los materiales superabsorbentes
Authors: Pérez Puyana Víctor Manuel , Jiménez Rosado Mercedes , Félix Ángel Manuel , Romero García Alberto
Published: March 2020

Los materiales superabsorbentes son aquellos materiales capaces de retener al menos 1000 veces su peso en agua (u otras sustancias) sin desintegrarse. Sus aplicaciones son muy variadas, desde productos para la higiene personal (toallitas, pañales) a la horticultura (fuente de agua). Estos materiales pueden elaborarse a partir de muchas materias primas, pero las más novedosas son las proteínas debido a su carácter biodegradable. A simple vista, estos materiales no tienen nada de especial, pero su microestructura está llena de poros. Esta cualidad, junto con sus propiedades mecánicas, hacen que estos materiales puedan retener el agua en los huecos libres mientras que se hinchan.

Para caracterizar estos materiales es necesario observar su microestructura, para ello se utiliza la microscopía electrónica de barrido, debido a que esta técnica es capaz de obtener fotografías de calidad a escala micro.

El Recurso creado ayuda a enseñar aspectos de extraordinaria relevancia de estos materiales como es su microestructura, dando a conocer puntos claves para el entendimiento de las imágenes así como de la interacción con ella.

El Recurso puede experimentarse directamente con el navegador en modo 360º tanto en equipos de escritorio como con dispositivos móviles. No obstante, es altamente recomendable una mejor experiencia inmersiva introduciéndose dentro de la esfera para apreciar bien su estructura, la cual puede obtenerse ayudándose de unas gafas de Realidad Virtual con las que pueda conectarse mediante Mozilla Firefox (Oculus, HTC Vive, Daydream o Cardboard).
A new kind of unified nuclear binding energy formula and its consequences
Authors: UVS Seshavatharam , S Lakshminarayana
Published: March 2020

Starting from Z=3 to 120, energy coefficient being 10.1 MeV - nuclear binding energy increases with increasing mass number, decreases with increasing number of free or unbound nucleons, decreases with increasing radius and decreases with increasing asymmetry about the mean stable mass number. Proceeding further, by considering the number of free or unbound nucleons, an attempt is made to understand the mass limits of nuclear stability zone. With further study, stable zones of relatively long living super heavy elements can be identified.
Hibernation Records on the Incisor Surface in the Turkish Hamster (Mesocricetus brandti) (Rodentia, Cricetidae)
Authors: Zaytseva E. A. , Chunkov M. M. , Omarov K. Z.
Published: March 2020

The teeth of an adult female of the Turkish hamster (Mesocricetus brandti) after hibernation in semi-natural conditions were examined to reveal a relationship between the hibernation pattern on the incisor surface and the data of a temperature logger. The female spent the winter in a burrow prepared by herself inside a wintering cage from October 2018 till May 2019. A temperature logger was implanted to the animal intraperitoneally to record body temperature at 20-min intervals. Regular bouts of hypothermia started in mid-October. The longevity of each hypothermia bout increased whereas the minimum body temperature decreased and reached its lowest value in March. Later, the process proceeded backwards until the end of the heterothermia period. In the apical region of the incisor, daily increments were wide and well-distinguished which indicates that they had formed before the onset of the heterothermal period. In the basal region, closer to the growth zone, the increments were narrow and distinct, and their number corresponded in general to the number of normothermia episodes bouts. At the very base of the incisor as well as at its apical part, typical daily increments were revealed again. However, no correlation between the longevity of normothermia bouts and the width of increments was found. These data varied greatly from two other hamsters. In the Ciscaucasian hamster (Mesocricetus raddei) the number and character of increments comply with the number and duration of normothermia bouts, in the Common hamster (Cricetus cricetus), the “hibernation zone” was not recorded on the incisor surface. The Turkish hamster demonstrate an intermediate pattern, which we explain by quite different hibernation conditions of these species.
Climatic Causes of Plant Flowering Time Displacement in the Central Forest Reserve
Authors: Zorina A. A. , Shuyskaya E. A. , Kurakina I. V. , Volkov V. P. , Ogurtsov S. S. , Stepanov S. N.
Published: March 2020

Meteorological series and phenological data in the framework of our environmental monitoring in the South taiga Central Forest Reserve were analyzed. During 1984– 2017, the average annual air temperature was 4.63±0.41°C, and the average annual rainfall was 2.14±0.12 mm/day. For eight of the 43 (19%) climatic parameters, reliable linear trends of variability were found: an increase of air temperature in July, August, September, and December; an increase of soil temperature in December; an increase of precipitation in November and December; and a decrease of precipitation in September. Three causes of their directed long-term changes were revealed, namely: a shift of the winter timing, violation of the annual dynamics of climatic parameters and a change in the precipitation type during a longer autumn – snow to be replaced by rain. Of the 11 species of vascular plants, the statistical significance of the long-term displacement of phenological dates was proven for Anemone nemorosa: the longer the autumn and softer the beginning of the winter, the earlier the onset of its flowering. Two classification types of vascular plants in identifying interspecific synchrony in the phenological events variation were considered. Variability components of phenological phenomena occurrence was estimated: the share of long-term trends of the shift in phenological dates timing due to changes in reserve climatic system is from 20 to 68% of the total sign dispersion; interannual climatic fluctuations explain 5–34% of its variability; and the proportion of variability under unaccounted factors influence is high (21–64%). Species with a high proportion of their long-term variability components (Anemone nemorosa: more than 60%) are recommended to use as indicators of climate change under the conditions of the study area.
Impact of Iron, Copper and Nickel Ions Introduced Into the Soil Separately and in Various Combinations on Soil Microbiota
Authors: Pleshakova Ye. V. , Zelenova N. A. , Ngun C. T. , Reshetnikov M. V.
Published: March 2020

In a long-term model experiment, the abundance dynamics of soil microorganisms was studied as affected by pollution of southern chernozem soils with various concentrations and combinations of iron, nickel and copper ions. In the course of this study, soil microbiocenoses were seeded on solid nutrient media and the following values were estimated: the total numbers of heterotrophic microorganisms on meat–peptone agar, the numbers of iron-oxidizing microorganisms on a selective medium in 0, 30, 90 and 210 days after the introduction of heavy metal ions into the soil. A characteristic diverse impact of heavy metal ions on soil microorganisms was established, and the degree of stability of soil microbocenoses of southern chernozem was revealed. Iron and copper concentrations of 10 and 50 RGCB/MPC in 30 days after soil contamination by individual metal ions or their combinations stimulated the proliferation of heterotrophic microorganisms in the soil microbocenoses and 90 days later the number of this microbial group decreased to the control levels and below. After 210 days, the microbiocenoses returned to a stable state. Nickel ions, introduced into the soil at a concentration of 50 MPC separately and in a number of combinations with other heavy metal ions, did not stimulate the proliferation of heterotrophic microorganisms. Opposite trends were observed in the abundance dynamics of iron-oxidizing microorganisms. With the exception of some model variants such as 10 and 50 MPC of Cu (II), iron, nickel and their combinations in various concentrations inhibited the proliferation of ironoxidizing microorganisms in the first month after soil contamination. The inhibitory effect of a combination of heavy metal ions was stronger than that of individual metals. After 90 days, the numbers of iron-oxidizing microorganisms restored to the control level or even exceeded it. After 210 days, an inhibition of the proliferation of ironoxidizing microorganisms was observed in the microbocenoses, or their abundance corresponded to the value in the control soil sample.
Formation of Forest Biogeocenoses on Disturbed Lands of the Northern Caspian Region
Authors: Sizemskaya M. L. , Elekesheva M. M. , Sapanov M. K.
Published: March 2020

Features, trends and the rates of formation of new forest biogeocenoses on anthropogenically disturbed lands, in particular, on an unused pond created on heavy loamy soils in the semi-desert of the Northern Caspian region are analyzed. At an early stage of spontaneous pond colonization by vegetation, the maximum influence on its development was exerted by the presence of a seed source 300 meters away – in the Arboretum of the Dzhanybek Research Station of the Institute of Forest Sciences (Russian Academy of Sciences) with 120 species of introduced tree and shrub plants. Initially 34 pioneer species colonized the lower parts of the unused pond, and 29 species survived by 2018. The formation of intrazonal willow-oleaster-poplar communities of a quasitugai type with a grass-wet-meadow association has been revealed. Their development was influenced by geographical isolation, self-regulation under rather unstable moisture conditions caused by occasional flooding by melt snow waters and bogging. A differentiation of the upper part of the soil-forming rock brought to the surface has occurred. The forest leaf litter has been formed from uncut moquette with a thickness of 1–2 cm, reaching currently quite substantial deposits of 0.953±0.196 kg/m2 , with the ash content reaching 13.85%. Ca prevails absolutely in the ash composition; while the amounts of Mg, Fe, and K are significantly lower. A humus horizon has been formed and the soil effervescence depth has changed. In the whole, for almost 40 years of vegetation colonization, the previously infertile substrate has acquired features of an immature soil, which is characterized by manifesttion of humus-accumulative process, gradual humification of organic matter and decarbonization of the material. In general, compact, diverse in structure, spontaneously arising self-developing forest biogeocenoses could significantly transform disturbed semi-desert territories. The peculiarities of their structure and the composition of emerging species make it possible to properly choose species preferred for landscaping.