bluuebunny/crossref_metadata_2025 huggingface dataset:
Penyuluhan Pencegahan Demam Berdarah dan Pelatihan Pembuatan Abate Alami dari Tanaman Sereh di Desa Bendiljati Wetan Sumbergempol
Authors: Susanto Heru , Elistya Novintan
Published: August 2022

ABSTRAK Peningkatan penderita DBD dipengaruhi faktor cuaca dan tingkat kesadaran masyarakat dalam menjaga kebersihan lingkungan, diperkirakan tahun ini yaitu 2022 terjadi ledakan kasus. Khususnya pada desa Bendiljati Wetan berdasarkan pemaparan tenaga kesehatan dari sarana kesehatan atau Ponkesdes, kasus DBD pada daerah tersebut masih sangat tinggi hingga menyebabkan kematian pada warga desa Bendiljati Wetan. Tujuan dari pengabdian ini adalah meningkatakan pengetahuan tentang demam berdarah dan pembuatan abate alami dari tanaman sereh masyarakat Desa Bendiljati Wetan Sumbergempol. Kegiatan berupa pelatihan pembuatan abate yang terbuat dari batang sereh dan penyuluhan terkait pencegahan dan pemberantasan nyamuk dan jentik nyamuk, khususnya penyebab demam berdarah. Kegiatan penyuluhan dan pelatihan pembuatan abate batang sereh dapat meningkatkan manfaat dari batang sereh dan juga meningkatkan pengetahuan masyarakat sebesar 80% tentang pencegahan penyakit DBD secara alami. Kata Kunci: Demam Berdarah, Sereh, Jentik Nyamuk.  ABSTRACT The increase in dengue fever sufferers is influenced by weather factors and the level of public awareness in maintaining environmental cleanliness, it is estimated that this year, namely 2022, there will be an explosion of cases. Especially in the village of Bendiljati Wetan, based on the exposure of health workers from health facilities or Ponkesdes, cases of DHF in the area are still very high, causing death to residents of Bendiljati Wetan village. The purpose of this service is to increase knowledge about dengue fever and the manufacture of natural abate from the lemongrass plant of the people of Bendiljati Wetan Sumbergempol Village. Activities in the form of training in making abate made from lemongrass stems and counseling related to the prevention and eradication of mosquitoes and mosquito larvae, especially the cause of dengue fever. Extension activities and training on making lemongrass stem abate can increase the benefits of lemongrass stems and also increase community knowledge by 80% about natural prevention of dengue disease.Keywords: Dengue Fever, Lemongrass, Mosquito Larvae
Penyuluhan Kesehatan tentang Pencegahan Stunting dengan Perbaikan Pola Asuh Gizi Mulai dari Masa Hamil sampai Balita
Authors: Abdurrahman Abdurrahman , Amiruddin Amiruddin , Bustami Bustami , Anasril Anasril , Husaini Muhammad , Mutiah Cut
Published: August 2022

ABSTRAK Balita merupakan kelompok umur yang sering mengalami kekurangan gizi dan stunting merupakan dampak dari masalah gizi balita. Stunting merupakan gambaran terhambatnya pertumbuhan sebagai akibat dari kurangnya asupan zat gizi dalam jangka waktu yang lama. Persentasi status gizi balita pendek di Indonesia Tahun 2013 mencapai 37,2%, angka ini lebih besar dari Tahun 2010 sebesar 35,6%, dan Tahun 2017 sebesar 36,8%, tidak menunjukkan penurunan/perbaikan yang signifikan. Pola asuh orang tua merupakan masalah yang dapat mempengaruhi terjadinya stunting pada balita. Pola asuh orang tua yang kurang memiliki peluang lebih besar anak terkena stunting. Maka dari itu pola asuh gizi pada ibu hamil dan juga ibu balita sangat penting ditingkatkan untuk menjadi lebih baik. Karena apabila pola asuh gizi sudah baik, tentunya akan berdampak pada pemenuhan kebutuhan gizi pada ibu hamil dan juga pada anak balita. Hasil dari penyuluhan kesehatan yang dilakukan dalam kegiatan pengabdian masyarakat ini telah meningkatkan pengetahuan ibu tentang pencegahan stunting dengan perbikan pola asuh gizi mulai dari masa kehamilan hingga usia anak balita. Kata Kunci: Kekurangan Gizi, Stunting, Penyuluhan  ABSTRACT Toddlers are an age group that often experience malnutrition and stunting is the impact of under-five nutrition problems. Stunting is a picture of stunted growth as a result of lack of nutrient intake for a long time. The percentage of short toddlers' nutritional status in Indonesia in 2013 reached 37.2%, this figure was higher than in 2010 at 35.6%, and in 2017 at 36.8%, showing no significant decline/improvement. Parenting is a problem that can affect the occurrence of stunting in toddlers. Poor parenting has a greater chance of children being stunted. Therefore, it is very important to improve the nutritional parenting pattern for pregnant women and mothers under five. Because if the nutritional parenting pattern is good, it will certainly have an impact on meeting the nutritional needs of pregnant women and also children under five. The results of health counseling carried out in this community service activity have increased mother's knowledge about stunting prevention by improving nutritional parenting patterns from pregnancy to toddler age.Keywords:  Malnutrition, Stunting, Counseling
Penyuluhan Kesehatan tentang Asam Urat Pada Masyarakat di Kampung Nendali Distrik Sentani Timur Kabupaten Jayapura
Authors: Thome Angela Librianty , Amir Nurhidayah , Said Fathia Fakhri Inayati , Nompo Rifki Sakinah , Patungo Viertianingsih , Iksan Ricky Riyanto , Yeni Roza Indra
Published: August 2022

ABSTRAK Kampung Nendali merupakan salah satu Kampung di Distrik Sentani Timur yang masih terdapat keluhan nyeri sendi. Tujuan pengabdian kepada masyarakat ini adalah untuk menjelaskan definisi sampai dengan pencegahan tentang asam urat melalui penyuluhan. Metode yang digunakan berupa penyuluhan Kesehatan yang dilakukan dengan bantuan leaflet serta metode ceramah, tanya jawab serta diskusi. Dari 30 peserta yang hadir pada penyuluhan seperti stakeholder kampung dan masyarakat kampung Nendali, sebelum dilakukan penyuluhan peserta telah mengetahui apa itu asam urat dan jenis makanan apa saja yang dapat menimbulkan hiperurisemia, namun untuk pencegahan serta penangannya belum tahu cara yang benar. Setelah dilakukan penyuluhan Kesehatan tentang asam urat, peserta secara keseluruhan dapat memahami dengan benar. Peserta tampak antusias mendengarkan dan mengikuti penyuluhan. Kegiatan penyuluhan ini berjalan kondusif disebabkan peserta memperhatikan materi yang disampaikan oleh penyaji dengan baik. Kata kunci: Asam Urat, Penyuluhan Kesehatan, Masyarakat  ABSTRACT Nendali Village is one of the villages in the East Sentani District where there are still complaints of joint pain. The purpose of this community services is to explain the definition to prevention of gout through counseling.The method used is in the form of health education which is carried out with the help of leaflets as well as lecture, question and answer and discussion methods. The 30 particicipants who attended the counselling such as village stakeholders and the Nendali village community, before the counselling the participants knew what uric acid was and what types of food could cause hyperuricemia, buat for prevention and handling they did not know the right way. Afte conducting health education about gout, the participants as a whole could understand correctly. Participant seemed enthusiastic to listen and follow the counselling. This outreach activity was conducive because the participants paid close attention to the education. Keywords : Uric acid, Health education, Community
Pelaksanaan Kelas Ibu Balita dengan Metode Focus Group Discussion (Fgd) dan Multimedia Di Posyandu Anyelir Wilayah Kerja Puskesmas Dempo Palembang
Authors: Virgian Kharisma , Setiawati Desy , Asmalinda Wita , Veratiwi Veratiwi
Published: August 2022

ABSTRAK Pemenuhan gizi yang adekuat pada balita merupakan hal yang sangat penting dalam mendukung pertumbuhan dan perkembangannya. Pengetahuan ibu yang baik tentang gizi balita juga merupakan faktor terpenting dalam mendukung tercapainya pemberian gizi yang adekuat bagi balita. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan ibu tentang gizi pada balita. Melalui pelaksanaan kelas ibu balita dengan menggunakan metode Focus Group Discussion (FGD) dan penggunaan multimedia berupa video sebagai media edukasi. Kegiatan kelas ibu balita ini dilaksanakan di Posyandu Anyelir Wilayah Kerja Puskesmas Dempo kota Palembang. Dilakukan pengukuran pengetahuan ibu dengan metode pre-test dan dan post-test. Evaluasi dari pelaksanaan kelas ibu balita dari kegiatan pre-test, nilai rata-rata sebesar 76,30, nilai tertinggi 81 dan terendah 50. Pada kegiatan post-test didapatkan nilai rata-rata sebesar 77,08, nilai tertinggi 89 dan terendah 45. Terdapat kenaikan nilai rata-rata sebelum dan sesudah dilaksanakan kelas ibu balita. Peningkatan pengetahuan ibu melalui kelas ibu balita merupakan salah satu cara yang sangat efektif untuk mendukung tumbuh kembang balita yang optimal. Dapat dilakukan dengan metode-metode lain yang lebih edukatif dan variatif. Kata Kunci: Kelas Ibu Balita, Metode Focus Group Discussion (FGD), Multimedia  ABSTRACT Adequate nutrition fulfillment in toddlers is very important in supporting their growth and development. Good maternal knowledge about toddler nutrition is also the most important factor in supporting the achievement of adequate nutrition for toddlers. This community service activity aims to increase maternal knowledge about nutrition in toddlers. Through the implementation of toddler mother classes using the Focus Group Discussion (FGD) method and the use of multimedia in the form of video as an educational medium. This toddler mother class activity was held at Posyandu Anyelir Working Area of Puskesmas Dempo Palembang city. Measurement of maternal knowledge by pre-test and post-test methods. Evaluation of the implementation of the toddler mother class from pre-test activities, an average score of 76.30,  a high score of 81, and a low of 50. In post-test activities, an average score of 77.08 was obtained, a high of 89 and a low of 45. There was an increase in average grades before and after the toddler mother class. Conclusion: Increasing maternal knowledge through the toddler mother class is one of the most effective ways to support optimal toddler growth and development. It can be done with other methods that are more educative and varied. Keywords: Mother-Toddles Class, Focus Group Discussions, Multimedia
Edukasi Pengolahan Makanan Pendamping Asi (MP-Asi) sebagai upaya Pencegahan Stunting pada Balita
Authors: Nurdin Sulkifli , Samson Meriem Meisyaroh , Sakinah Sri , Asnuddin Asnuddin , Hasrul Hasrul , Murtini Murtini
Published: August 2022

ABSTRAK Tingginya angka stunting di Kabupaten Sidenreng Rappang Provisnsi Sulawesi Selatan, Indonesia. Salah satu Desa yang cukup tinggi adalah Desa Cenrana Kecamatan Panca Lautang. Survai awal yang dilakukan ditemukan kelompok Ibu cenderung kurang memeiliki pengetahuan dan keterampilan dalam upaya pencegahan stunting, ITKeS Muhammadiyah Sidrap merupakan salah satu perguruan tinggi swasta dibidang Kesehatan yang berperan dalam program pemerintah dalam pencegahan dan penanganan stunting. Tujuan Pelaksanaan pengabdian kepada masyarakat ini merupakan upaya peningkatan gizi anak dalam pencegahan stunting melalui kegiatan pemberian edukasi pengolahan makanan pendampinga ASI (MP-ASI). Metode edukasi dalam bentuk dialog interktif dan mendemostrasikan pembuatan makanan tambahan pendamping asi (MP-ASI) yang mudah diolah dan kaya akan gizi balita untuk mencegah stunting. Kegiatan ini berhasil meningkatkan pengetahuan dan kemampuan dalam pengolahan makanan tambahan pendamping ASI berbahan lokal. Setelah kegiatan ini dilakukan terdapat perubahan perilaku peserta dalam memilih dan mengolah makanan tambahan untuk anak balitanya untuk pencehagan stunting.   Kata Kunci: MP-ASI, Stunting;, Masyarakat;, Pangan Lokal  ABSTRACT The high stunting rate in Sidenreng Rappang Regency, South Sulawesi Province, Indonesia. One of the villages that is quite high is Cenrana Village, Panca Lautang District. The preliminary data found that the mother group tended to lack knowledge and skills in prevention stunting, ITKeS Muhammadiyah Sidrap is one of the private universities in the health sector that plays a role in government programs in stunting prevention and management. The purpose of implementing this community service is an effort to improve children's nutrition in preventing stunting through providing education on processing complementary foods for breastfeeding (MP-ASI). The educational method is in the form of interactive dialogue and demonstration of making complementary food for complementary feeding (MP-ASI) which is easy to process and rich in toddler nutrition to prevent stunting. This activity succeeded in increasing knowledge and ability in processing complementary foods made from local complementary foods. After this activity was carried out there was a change in the behavior of participants in choosing and processing additional food for their toddlers to prevent stunting. Keyword: MP-ASI, Stunting, Public, Local Food
Pengaruh Lama Penggunaan Gadget dan Indeks Massa Tubuh terhadap Kelelahan Fisik Mahasiswa Fk Ums pada Masa Pandemi Covid-19
Authors: Rosyida Hindun Luthfia , Agustina Tri , Lestari Nining , Pramuningtyas Ratih
Published: August 2022

ABSTRACT Indonesia is one of the countries affected by the Covid-19 virus, so many activities are diverted online, leading to increased duration of using gadgets and decreased physical activity, so that it give rise to physical fatigue. The purpose of this study was to find out how much effect duration of using gadgets and body mass index on physical fatigue of FK UMS students during the COVID-19 pandemic. The research data was obtained from the distribution of online questionnaires. Respondents in this research were medical student from Muhammadiyah University of Surakarta 2018, were obtained as many as 114 people, consisting of 90 women and 24 men, with an average age of 21 years. In the analysis of the results with bivariate tests, it was found that the effect of duration of using gadgets to physical fatigue of FK UMS students during the COVID-19 pandemic was p=0,021 (p<0,05), and the effect of Body Mass Index to physical fatigue of FK UMS students during the COVID-19 pandemic p=0,021 (p<0,05). The result with multivariate test The duration of using gadgets and Body Mass Index affect the physical fatigue of FK UMS students during the COVID-19 pandemic is not significal, because Exp (b) OR = 5,308 and p value was 0,119 (p>0,05).  Keywords: Duration Of Using Gadgets, Body Mass Indeks, Physical Fatigue  ABSTRAK Indonesia merupakan salah satu negara yang terkena dampak dari virus Covid-19, sehingga banyak kegiatan yang dialihkan secara online (daring) menyebabkan meningkatnya penggunaan gadget dan menurunnya aktivitas fisik, sehingga mengakibatkan kelelahan fisik. Tujuan penelitian ini mengetahui seberapa pengaruh lama penggunaan gadget dan indeks massa tubuh terhadap kelelahan fisik mahasiswa FK UMS pada masa pandemi COVID-19. Penelitian ini menggunakan jenis penelitian analitik observasional dengan pendekatan cross sectional. Data-data penelitian diperoleh dari pembagian kuesioner secara daring. Responden pada penelitian ini merupakan mahasiswa FK UMS angkatan 2018 didapatkan sebanyak 114 orang, terdiri dari 90 perempuan dan 24 laki-laki, dengan usia rata-rata 21 tahun. Pada analisis hasil dengan uji bivariate didapatkan pengaruh lama penggunaan gadget berpengaruh terhadap kelelahan fisik dengan p=0,021 (p<0,05), dan Indeks Massa Tubuh berpengaruh terhadap kelelahan fisik dengan p=0,021 (p<0,05), tertapi secara multivariate (bersamaan) tidak ada pengaruh yang signifikan, memiliki nilai Exp (b) atau OR = 5,308 dan p sebesar 0,119 (p>0,05). Kata Kunci: Lama Penggunaan Gadget, Indeks Massa Tubuh, Kelelahan Fisik
Application of the IRAP Method Combined with GIS to Improve Road Safety on New Highway Projects in Algeria
Authors: Derras Abdelhak , Amara Khaled , Oulha Ramdane
Published: August 2022

This article aims to proactively predict high-risk accident areas in a new highway project in terms of its technical and geometric characteristics. The purpose of this study is to provide road project managers with better road safety assessment tools for the vehicle occupant category. The methodology used combines the International Road Assessment Program (IRAP) methodology and the Geographic Information System (GIS). The IRAP program enables the calculation and classification of risks for each 100-meter segment besides their categorization using a star rating; whereas, the GIS is used to map the risks and identify high-risk accident segments. This method was applied to a new highway project of 110 hectometres located in GHAZAOUET in Algeria. The results of the study revealed that this combined method is innovative in more than one way as it is an effective decision-making aid tool for road safety experts. It, therefore, makes it possible to target accident-prone sections in a faster way before carrying out on site road safety inspections. Technically speaking, this study shows that the existence of closely curved radii mixed at traffic speeds exceeding 80 km/h and the presence of road exits are the main factors affecting the safety of vehicle occupants. Speed control; thus, remains one among the cheapest measures to improve safety.
A MARC21 tételfejének és kódolt tartalmi jellemzőinek feldolgozási minősége néhány nemzeti könyvtárban
Authors: Rudolf Ungváry , Péter Király
Published: August 2022

Előző munkánkban összevetettük a nagyobb nemzeti könyvtárak MAR21 állományában a tartalmi adatmezők (648, 65X) feldolgozottságát. E tanulmányban a kötelezően kitöltendő tételfej és bizonyos kódolt tartalmi jellemző (007 és 008) feldolgozottságával foglalkozunk. Ezekben egy karakteres alfanumerikus jelzetekből („kódokból”) álló enumeratív osztályozási rendszerek szerint kell, illetve kellene minősíteni a forrásokat. Kiderült, hogy az utóbbi két mező pozícióinak használata rendkívül szegényes. Ez egyrészt összefügg a nem kötelező voltukkal, másrészt a MARC vonatkozó osztályozási rendszereinek hiányosságaival, ill. azzal, hogy más adatmezőkhöz képes (megjegyzés mezők és tartalmi adatmezők) tapasztalható redundanciákkal, ami miatt a 00X mezők feldolgozását elhanyagolják. Holott egyrészt kitöltésük az információkeresés szempontjából rendkívül hasznos lenne – ha a könyvtári rendszerek keresőit felkészítenék a keresésben a felhasználóbarát lehetőségekre.
O sentido social e os desafios da função pública no Brasil e na França
Authors: Venco Selma , Aschieri Gérard , Kenji Seki Allan
Published: August 2022

O presente artigo tem como objetivo analisar a constituição e o desenvolvimento da função pública em dois países com trajetórias históricas e contextos social, político e econômico díspares: Brasil e França. Toma-se como hipótese que os processos de descaracterização – e mesmo o ocaso - da função pública atingem, ainda que de maneiras diferenciadas, ambos os países. A pesquisa documental abarcou os marcos legais concernentes à edificação da função pública na França e no Brasil, com vistas a compreender os direitos constituídos ao longo da história ao funcionalismo público, cujo trabalho volta-se ao interesse geral da população, é dotado de autonomia e, porta, assim, responsabilidade social. O tema adquire especial relevância, em virtude de estar em curso no Brasil o debate acerca da Reforma Administrativa, a qual está igualmente pautada na França. Constata-se que mesmo a França com forte adesão ao Estado do Bem-Estar-Social vem gradativamente adotando a Nova Gestão Pública e com tentativas de alterar o estatuto do funcionalismo público. No Brasil, por sua vez, desde o fim da ditadura empresarial-militar adotam-se políticas neoliberais, com nítido aprofundamento da cassação de direitos desde o golpe de 2016.  Indica-se, ainda que com as devidas proporções, os dois países analisados convergem na adoção de medidas de caráter ultraliberal, com vistas a padronizar políticas de contratação e salariais para os setores público e privado.

PALAVRAS-CHAVE: Função pública brasileira; Função pública francesa; Funcionalismo Público.
Метаболітотропні кардіо- та ендотеліопротектори: сучасний погляд і перспективи створення
Authors: Риженко В. П. , Горчакова Н. О. , Бєленічев І. Ф. , Бухтіярова Н. В. , Кучковський О. М. , Бесcараб Г. І. , Нефьодов О. О.
Published: August 2022

Мета дослідження – проаналізувати дані літератури та результати власних досліджень щодо механізмів розвитку ендотеліальної дисфункції при серцево-судинних захворюваннях та створення нових метаболітотропних кардіо- та ендотеліопротекторів. У дослідженні використані бібліосемантичний, аналітичний, логічний методи та метод узагальнення. У бібліографічній базі даних медико-біологічної та біомедичної інформації MEDLINE, EMBASE, Medline (PubMed), Web of Science та Cochrane Central проведено пошук публікацій англійською мовою, що відповідають ключовим словам цього дослідження: метаболітотропні кардіопротектори, ендотеліопротекторна активність, кардіопротекторна актівність, лікування, сердцево-судинні захворювання, дисфункція ендотелію. Обговорюється зв’язок між ендотеліальною дисфункцією та розвитком або прогресуванням серцево-судинних захворювань, станів, що супроводжуються метаболічними порушеннями. Показано роль нітроксидергічної системи в молекулярних механізмах дисфункції ендотелію. Наведено фармакологічні характеристики відомих метаболітотропних кардіопротекторів – тіотриазоліну, мілдронату та мексидолу, а також результати експериментальних досліджень нового метаболітотропного ендотеліопротектора Ангіоліну. Зроблено висновок про доцільність подальшого пошуку кардіопротекторів серед похідних L-лізину. Враховуючи роль нітроксидергічної системи в ішемічному пошкодженні міокарда перспективним може бути віртуальний скринінг пасток оксиду азота серед похідних L-лізину, структури яких є в комбінаторних бібліотеках відкритого доступу.
Анксіолітичні властивості аналога кінцевого фрагмента нейропептиду Y та його вплив на вміст нейроактивних амінокислот у головному мозку
Authors: Гаврилов І. О. , Штриголь С. Ю. , Горбач Т. В.
Published: August 2022

Мета дослідження – поглиблено вивчити анксіолітичні властивості нонапептиду NP9 на мишах і щурах, з’ясувати його вплив на вміст нейроактивних амінокислот у головному мозку. Експеримент проведено на 45 білих нелінійних мишах (24 самки, 21 самець) і на 24 нелінійних щурах-самцях. Нонапептид NP9 вводили інтраназально в дозі 0,2 мг/кг мишам і в дозах 0,05 та 0,1 мг/кг щурам. Як препарати порівняння використовували Семакс (Пептоген, РФ) у дозі 0,1 мг/кг інтраназально мишам і гідазепам (Гідазепам IC, Інтерхім, Україна) у дозі 5 мг/кг внутрішньошлунково щурам. Поведінкові реакції вивчали в тестах «Відкрите поле» і «Піднесений хрестоподібний лабіринт» на мишах. Анксіолітичні властивості вивчали також у тесті конфліктної ситуації за H. G. Vogel на щурах. Визначали вміст гліцину, гамма-аміномасляної кислоти (ГАМК), глутамату й аспартату в головному мозку мишей. Нонапетид NP9 суттєво знижував тривожність мишей без пригнічення рухової активності та будьяких ознак седації в тестах «Відкрите поле» і «Піднесений хрестоподібний лабіринт», що відповідає результатам попередніх досліджень на щурах. Його анксіолітична активність була стабільнішою, ніж у Семаксу. У тесті конфліктної ситуації за H. G. Vogel на щурах підтверджені анксіолітичні властивості нонапептиду в дозах 0,05 мг/кг та особливо 0,1 мг/кг, за протитривожною дією він не поступався гідазепаму в дозі 5 мг/кг. Після триденного інтраназального введення NP9 (0,2 мг/кг) мишам у гомогенаті головного мозку збільшувався вміст глутамату та аспартату при зниженні вмісту гліцину та ГАМК. Таким чином, анксіолітичні властивості нонапептиду NP9 підтверджено як на мишах, так і на щурах. Його дія є анксіоселективною, оскільки не супроводжується загальним пригніченням тварин. Досліджуваний нонапептид після триденного інтраназального введення мишам підвищує вміст глутамату й аспартату, а також знижує вміст гліцину та ГАМК у головному мозку.
Гіпоурикемічна дія та гостра токсичність екстракту листя любистку лікарського (Levisticum оfficinale Koch)
Authors: Койро О. О. , Шемаруліна А. І. , Кононенко А. В. , Штриголь С. Ю.
Published: August 2022

Мета дослідження – з’ясувати в експерименті вплив рідкого водно-спиртового екстракту листя любистку лікарського (ЕЛЛЛ) на обмін сечової кислоти (СК) у нормі та на моделі гіперурикемії, визначити гостру токсичність зазначеного екстракту. ЕЛЛЛ отримано методом перколяції, як екстрагент використано 70 % етиловий спирт. В експерименті на мишах визначали вплив 7-денного введення ЕЛЛЛ (з якого попередньо відганяли спирт відновлювали об’єм водою) у дозах 1 мл/кг і 5 мл/кг на вміст СК у крові, на ниркову екскрецію СК в інтактних мишей і на моделі гіперурикемії, викликаної калію оксонатом, а також на активність ксантиноксидази (КО) у печінці. Як препарат порівняння використано алопуринол (10 мг/кг у шлунок). Аналізували кореляційні зв’язки між зазначеними показниками пуринового обміну. Експрес-методом визначали гостру токсичність ЕЛЛЛ. Позбавлений спирту ЕЛЛЛ в інтактних тварин чинив помірний, а на моделі оксонат-індукованої гіперурикемії – виразніший гіпоурикемічний вплив (у дозі 5 мл/кг знижував вміст СК у крові на 47 %, p < 0,01). За виразністю гіпоурикемічного ефекту ЕЛЛЛ поступався алопуринолу. Механізм гіпоурикемічного впливу ЕЛЛЛ, як і алопуринолу, полягає в інгібуванні КО (активність ензиму зменшувалась на 37–51 % за нормоурикемії та на 51–57 % за гіперурикемії). Роль цього механізму підтверджується результатами кореляційного аналізу зв’язку між урикемією та активністю КО. Як ЕЛЛЛ у дозі 5 мл/кг, так і алопуринол в умовах оксонат-індукованої моделі гіперурикемії відновлювали прямий кореляційний зв’язок між концентрацією в крові СК та активністю КО (відповідно ρ = 0,68 і ρ = 0,88), притаманний інтактним тваринам (ρ = 0,86) і порушений оксонатом калію (ρ = –0,04). Ниркова екскреція СК під впливом ЕЛЛЛ зменшувалась. ЕЛЛЛ належить до практично нетоксичних речовин (V клас токсичності, 5000 < LD50 < 15 000 мг/кг при визначенні експрес-методом).
EFL classroom learning environment at a Thai university: What variables matter for low-proficiency students?
Authors: Waluyo Budi , Arsyad Safnil
Published: August 2022

This study investigated the EFL classroom learning environment at a university in Thailand from the perspective of low-English proficiency students. Using structural equation modelling, five hypotheses involving variables generated by students and teachers were investigated (SEM). According to the findings, task orientation in low-proficiency students was the key to boosting students' English course grades. In the case of low-proficiency students, equity, teacher support, and student cooperation were not found to be important. Student cohesion was also found to be an unreliable predictor of students' English grades. Because research on the classroom learning environment engaging low students is still limited, these findings suggest future investigation.
INTESTINAL PARASITE INFECTIONS AND ASSOCIATED RISK FACTORS IN INHABITANTS OF THE CITY OF YAOUNDÉ, CAMEROON
Authors: LAURELLE Djıeukap , AWONO-AMBENE Herman Parfait , ANTONİO-NKONDJİO Christophe , BALİFELİ Bienvenu , FRU Chi Tchampo , NDO Cyrille , DOLOGUELE Nicolas Félicien , ZEBAZÉ TOGOUET Serge Hubert , NJİOKOU Flobert
Published: August 2022

Intestinal parasite infections are still prevalent in developing countries and in Cameroon where over 90% of the population is at high risk. To assess the distribution of intestinal parasitic infections and risk factors of the city of Yaoundé, both household and parasitological surveys were conducted from October to December 2019 among inhabitants of lowlands aged from 15 years and over. Stools samples were collected and screened for intestinal parasites presence using Kato Katz and Formol-Ether methods. Sociodemographic status, prevention measures against intestinal parasitic diseases and practices with increase exposition to risky environments were then recorded.

A total of 229 participants (142 females: 62.0%; 87 males: 38.0%) were enrolled for the study, and 24.02% (55/229) were found infected by helminthes (ten species) and/or protozoans (one species). Participant infection rates and risk varied by parasite species and socio-demographic factors. Global risk analysis showed that age (OR ranges: 3.78-15.96), anti-parasitic drug consumption (OR: 2.53), eating behavior,,hygiene (OR: 22.4), occupation (OR ranges: 1.92-3.53) and type of toilets (OR: 3.4) were strongly associated with risk of infection by intestinal parasites. The risk increased in 15-30 years age group for A. lumbricoïdes, T. trichiura and Schistosoma mansoni, unpredictably in those washing their hands before meals for A. lumbricoïdes and H. nana, in respondents using antiparasitic drugs as auto-medication for H. nana and in those using traditional toilets for A. lumbricoïdes. However, other variables with high OR values (> 5.0) might be potential risk factor for the occurrence of specific parasite infections. The study suggests the need for household sensitization and community actions including integrated environmental management as complement strategy to reduce intestinal parasite transmission in the city of Yaoundé.
Keefektifan buku ajar berbasis literasi matematika untuk materi “persamaan kuadrat dan fungsi kuadrat”
Authors: Ladyawati Erlin , Rahayu Sri
Published: August 2022

Tujuan utama dari penelitian ini adalah untuk mengembangkan suatu produk buku ajar berbasis literasi matematika serta untuk mengetahui keefektifan pengembangan buku ajar berbasis literasi. Syarat kevalidan buku ajar ini ditentukan dari kelayakan isi, sajian dan grafik sedangkan keefektifan ditentukan dari angket respon siswa yang bernilai positif dan ketuntasan belajar secara klasikal. Penelitian ini merupakan jenis penelitian Research and Development (R&D), sedangkan pengembangan buku ajar ini menggunakan model ADDIE kependekan dari Analyze, Design, Development, Implementation, and Evaluation. Produk yang dihasilkan pada penelitian ini adalah bahan ajar matematika yang berbasis literasi untuk jenjang Sekolah Menengah Pertama dengan model pengembangan ADDIE. Subyek penelitian ini adalah siswa SMP Mutiara Bunda kelas IX yang berjumlah 15 orang. Dari penelitian ini dihasilkan produk buku ajar Persamaan Kuadrat dan Fungsi Kuadrat untuk kelas IX Sekolah Menengah Pertama yang memenuhi hasil uji kelayakan isi, sajian dan grafik mencapai kriteria “sangat baik” dengan revisi secukupnya dan uji keterbacaan diperoleh kriteria “sangat baik” tanpa revisi. Data respon siswa terhadap penggunaan buku ajar memenuhi kriteria positif dan tes hasil belajar mencapai ketuntasan klasikal. Dari hasil tersebut dapat disimpulkan bahwa pengembangan buku ajar berbasis literasi matematika untuk materi Persamaan Kuadrat Dan Fungsi Kuadrat memenuhi kriteria valid dan efektif.
Penerapan Relaksasi Otot Progresif Untuk Menurunkan Tingkat Kecemasan Pada Remaja Di Masa Pandemi Covid-19
Authors: Nurfitriyani Eka , Sugiyanto Emilia Puspitasari
Published: August 2022

COVID-19 merupakan penyakit baru yang dapat menyebabkan terjadinya gangguan pernafasan dan radang paru. Menyebarnya COVID-19 di seluruh dunia membuat WHO menyatakan situasi ini sebagai pandemi. Kondisi yang baru ini dapat menimbulkan kecemasan bagi segala kalangan, salah satunya remaja. Tujuan studi kasus ini untukmenyusun resume asuhan keperawatan dalam penerapan teknik relaksasi otot progresif untuk menurunkan kecemasan pada remaja di masa pandemi COVID-19. Jenis penelitian ini adalah deskriptif dengan metode studi kasus dalam rancangan one group pretest posttest. Subyek dari penelitian ini adalah dua pasien dengan kriteria inklusi berupa pasien yang bersedia menjadi responden, responden termasuk dalam usia remaja, responden mengalami kecemasan di masa pandemi COVID-19. Pengambilan data menggunakan kuisioner penilaian skala HARS. Hasil studi menunjukkan bahwa dua pasien yaitu pasien I dan pasien II yang telah diberikan terapi relaksasi otot progresif sebanyak satu kali sehari selama tiga hari mengalami penurunan tingkat kecemasan yaitu pasien I dengan skor 26 (cemas sedang) menjadi 4 (tidak cemas) dan pasien II dengan skor awal 22 (cemas sedang) menjadi 3 (tidak cemas). Disimpulkan bahwa terapi relaksasi otot progresif dapat menurunkan kecemasan pada remaja yang mengalami kecemasan di masa pandemi COVID-19.
A Rift between Worlds: The Retro-1980s and the Neoliberal Upside Down in Stranger Things
Authors: Fhlainn Sorcha Ní
Published: August 2022

The Netflix series Stranger Things (2016–) is one of a host of recent 1980s-set texts that returns to the decade through the lens of cultural nostalgia. Recalling and resituating its viewers in the Reagan era, the series presents a contemporary Gothic narrative by returning to the 1980s as a period of profound cultural importance, setting its secondary Gothic space, The Upside Down, as a Gothic neoliberal shadow world that conveys profound implications for a terrifying future. Examining the 1980s as a nexus point for socio-political anxieties and nostalgic recall, which has dominated the economic landscape and many Hollywood films and shows in the twenty-first century, this article argues that Stranger Things situates its characters at the precipice of a wrong turn in history, a period in which its youthful band of heroes, like their 1980s counterparts in its science fiction and fantasy cinema before them, must chase down their own futures to prevent a terrible fate. Through ‘reflective nostalgia’, this rift between the 1980s onscreen and the shadow future of the Upside Down is presented as a diachronic narrative, a return to the past to identify and critique the 1980s as a point of origin for numerous socio-economic anxieties and ills in our contemporary neoliberal Gothic world. Stranger Things, alongside other 1980s retro-texts, articulates our own Gothic terrors in the contemporary moment. Moreover, this article argues how and why the Gothic 1980s is a revisited site of return from which we need to learn, particularly following the post-2008 financial crisis, to overcome the necro-economic consequences of the ‘Upside Down’ neoliberal wasteland of the twenty-first century.
HUBUNGAN STATUS GIZI DENGAN KEJADIAN ANEMIA PADA REMAJA PUTRI DI SMP ALALAK KABUPATEN BARITO KUALA TAHUN 2019
Authors: Purwanti Purwanti , Iswandari Novita Dewi , Ulfa Ika Mardiatul
Published: August 2022

Â Latar Belakang: Angka kejadian anemia di Puskesmas Semangat Dalam pada remaja putri berdasarkan data penjaringan tahun 2018 dari total 328Â  remajaÂ  putri 114 mengalami anemia (35%), tahun 2019 dari total 223 remaja putri 92 orang mengalami anemia (41,26%).Tujuan: MengetahuiÂ  hubungan status gizi dengan kejadian anemia pada remajaÂ Â  putriÂ  di SMP Alalak Kabupaten Barito Kuala.Metode: Metode penelitian ini kuantitatif, dengan rancangan penelitian Cross Sectional. Populasi yang di gunakan dalam penelitian ini adalah remaja putri yang baru masuk di bangku SMP Alalak Kabupaten Barito Kuala pada tahun ajaran 2019-2020,dengan jumlah 223 orang dan jumlah sampel 100 orang dengan alat pengumpulan data adalahÂ  checklist. Data dianalisis menggunaka uji Chi-Square.Hasil: hubungan status gizi dengan kejadian anemia pada remaja yaitu p value =0,000.Kesimpulan: Ada hubungan status gizi dengan kejadian anemia pada remaja putri di SMP Alalak Kabupaten Barito Kuala.Saran: Dapat dijadikan acuan dalam menyusun rencana program kegiatan remaja ke sekolah pada tahun selanjutnya, dimana program tersebut meliputi pembagian tablet tanbah darah, penyuluhan gizi seimbang, penyuluhan kesehatan reproduksi dan pembinaan konselor sebaya.Kata Kunci: Anemia Pada Remaja Puteri, Gizi Remaja Putri, Status GiziÂ Background: The incidence of anemia at the Semangat Dalam Health Center for young women based on 2018 data from a total of 328 young women 114 experienced anemia (35%), in 2019 out of a total of 223 young women 92 people experienced anemia (41.26%).Objective: To determine the relationship between nutritional status and the incidence of anemia in teenage girls at SMP Alalak, Barito Kuala RegencyMethods: This research method was quantitative, with a cross-sectional research design. The population used in this study were teenage girls who had recently entered SMP Alalak, Barito Kuala Regency in the 2019-2020 school year, with a total of 223 people and a sample size of 100 people with the data collection instrument using the checklist. Data were analyzed using the Chi-Square test.Results: The relationship between nutritional status with the incidence of anemia in adolescents is p-value = 0.000.Conclusion: There is a relationship between nutritional status and the incidence of anemia in teenage girls at SMP Alalak, Barito Kuala Regency.Advice: This canÂ be used as a reference in planning youth activity programs to school in the following year, where the program includes distribution of blood tablets, balanced nutrition education, reproductive health education, and peer counselor development.Â Keywords: Anemia in Teenage Girls, Nutrition for Young Women, Nutritional Status
Nasal carriage of CTX-M-55-producing Escherichia coli ST8369 in a healthy cohort in the city of Yangzhou, China
Authors: Wang Zhen-Yu , Jiang Yue , Shao Yi-Qiao , Lu Heng-Fan , Lu Meng-Jun , Jiao Xinan , Li Qiu-Chun , Wang Jing
Published: August 2022

This study aimed to investigate the prevalence and diversity of extended-spectrum β-lactamases (ESBL)-producing Escherichia coli isolates from healthy individuals in a community and to elucidate their dissemination mechanism. Cefotaxime-resistant E. coli were isolated from 95 samples of healthy persons from one community in Yangzhou, China, and were tested for minimal inhibitory concentrations of 14 antimicrobial agents. The isolates were subjected to whole genome sequencing by Illumina Hiseq or PacBio single-molecule real-time sequencing. A total of 30 cefotaxime-resistant E. coli isolates were obtained, carrying blaCTX-M (n=29) or blaDHA (n=1), of which the blaCTX-M-55 (n=19) was the most predominant genotype. One novel blaCTX-M variant blaCTX-M-252 was identified. Thirteen CTX-M-55-producing E. coli isolates belonged to ST8369 from nasal (n=12) or faecal (n=1) samples shared the identical cgMLST type, resistance profiles, resistance genes, plasmid replicons, and a 5,053-bp blaCTX-M-55 structure ΔIS26-ΔISEcp1-blaCTX-M-55-Δorf477-ΔTn2. The blaCTX-M-55 gene was located on IncHI2/ST3 plasmid in E. coli ST8369. The lengths of blaCTX-M/blaDHA-carrying contigs in the remaining 17 E. coli strains ranged from 1,663 to 382,836 bp, located on chromosome (n=4) or plasmids (n=5); the location of the other eight contigs could not be determined due to incomplete assembly. The blaCTX-M was associated with ISEcp1 as previously reported. Nasal colonization of CTX-M-55-producing ST8369 E. coli strains has occurred among healthy individuals in one community. There is a potential risk of antimicrobial resistance dissemination between humans within one community through close contact or environment via aerosols or dust. Therefore, surveillance of nasal carriage of blaCTX-M in communities is warranted to further monitor the spread of the antimicrobial resistance genes in China.
The contribution of different face parts to deep face recognition
Authors: Lestriandoko Nova Hadi , Veldhuis Raymond , Spreeuwers Luuk
Published: August 2022

The development of face recognition improvements still lacks knowledge on what parts of the face are important. In this article, the authors present face parts analysis to obtain important recognition information in a certain area of the face, more than just the eye or eyebrow, from the black box perspective. In addition, the authors propose a more advanced way to select parts without introducing artifacts using the average face and morphing. Furthermore, multiple face recognition systems are used to analyze the face component contribution. Finally, the results show that the four deep face recognition systems produce a different behavior for each experiment. However, the eyebrows are still the most important part of deep face recognition systems. In addition, the face texture played an important role deeper than the face shape.
Case report: Minimally invasive excision of multifocal cardiac papillary fibroelastomas involving right atrium and aortic valve
Authors: Teng Peng , Hu Peng , Yuan Shuai , Ma Liang
Published: August 2022

Background

Cardiac papillary fibroelastomas (CPFs) are rare benign cardiac tumors most commonly found on left-sided cardiac valves. Right atrial CPFs are extremely rare, accounting for only 2% of all CPFs. Median sternotomy is a typical approach for surgical excision of CPFs in most cases. Herein, we report an extremely rare case of multifocal CPFs involving the right atrium and aortic valve that were surgically excised via minimally invasive right anterolateral thoracotomy.

Case Summary

A 59-year-old Chinese man was admitted because of an incidental finding of a right atrial mass on transthoracic echocardiography during a routine check-up. The mass was initially diagnosed as a myxoma, and the patient was scheduled for minimally invasive excision via right anterolateral thoracotomy. An additional mass on the non-coronary cusp of the aortic valve was identified using intraoperative transesophageal echocardiography. The patient still underwent complete tumor excision via right anterolateral thoracotomy. Both neoplasms were pathologically diagnosed as CPFs.

Conclusions

This case highlights the need for a comprehensive cardiac evaluation of cardiac tumors because CPFs can manifest as multifocal lesions. Moreover, minimally invasive surgery is highly feasible as the CPF can be easily excised, and the valve can usually be preserved.
Anthracycline-induced cardiotoxicity: From pathobiology to identification of molecular targets for nuclear imaging
Authors: Jong Jeremy , Pinney James R. , Packard René R. Sevag
Published: August 2022

Anthracyclines are a widely used class of chemotherapy in pediatric and adult cancers, however, their use is hampered by the development of cardiotoxic side-effects and ensuing complications, primarily heart failure. Clinically used imaging modalities to screen for cardiotoxicity are mostly echocardiography and occasionally cardiac magnetic resonance imaging. However, the assessment of diastolic and global or segmental systolic function may not be sensitive to detect subclinical or early stages of cardiotoxicity. Multiple studies have scrutinized molecular nuclear imaging strategies to improve the detection of anthracycline-induced cardiotoxicity. Anthracyclines can activate all forms of cell death in cardiomyocytes. Injury mechanisms associated with anthracycline usage include apoptosis, necrosis, autophagy, ferroptosis, pyroptosis, reactive oxygen species, mitochondrial dysfunction, as well as cardiac fibrosis and perturbation in sympathetic drive and myocardial blood flow; some of which have been targeted using nuclear probes. This review retraces the pathobiology of anthracycline-induced cardiac injury, details the evidence to date supporting a molecular nuclear imaging strategy, explores disease mechanisms which have not yet been targeted, and proposes a clinical strategy incorporating molecular imaging to improve patient management.
Translational research in health technologies: A scoping review
Authors: Mayrink Nadja N. V. , Alcoforado Luís , Chioro Arthur , Fernandes Felipe , Lima Thaisa S. , Camargo Erika B. , Valentim Ricardo A. M.
Published: August 2022

Introduction

The current debate on the process of technological innovation points out as a challenge for universities consolidation of competencies that allow the generation and transfer of knowledge to society. The Translational Research (TR) approach has as one of its main objectives the acceleration of the innovation process, based on the transposition from basic science to applied science and innovation, which comprises the different stages of research, development and innovation. The literature points out that the dynamics of translation, which results in new technologies, are complex, transdisciplinary, inter-institutional, systemic, and non-linear. The main objective of this review is to contribute to the adoption of institutional strategies and the formulation of public policies aimed at solving today’s social and economic challenges, ensuring access to technologies and sustainability for the health system. The specific objectives were: (i) to systematize studies that characterized translational research in medical devices; (ii) map the challenges for the implementation of translational health research; (iii) contribute to the design of institutional strategies; and (iv) support the formulation of public policies.

Methods

This study used the scoping review technique, according to PRISMA-ScR and the Joanna Briggs Institute guidelines. Concerning the extraction of relevant articles, the journals indexed in Bireme, Pubmed, Scopus, Web of Science, and Google Scholar were consulted for selecting relevant articles. The search was carried out on November 28, 2021, updated on April 29, 2022, and there were no restrictions as to the year of publication, language or type of analysis. Studies that did not answer the research question were excluded, as they dealt exclusively with the pharmaceutical segment, the translation of knowledge into clinical practice, or addressed the process of translational research applied to specific diseases or technologies.

Results

Thirty-three articles were included indicating that the approach of translation of research is multidisciplinary and transdisciplinary and encompasses knowledge and aspects that go beyond basic and applied research and incorporates final steps concerning regulatory aspects, clinical research, market analysis, technology transfer, production and incorporation of technologies into the health system.
Integrating Data Science and the Internet of Things Into Science, Technology, Engineering, Arts, and Mathematics Education Through the Use of New and Emerging Technologies
Authors: Liston Maeve , Morrin Anne M. , Furlong Trevor , Griffin Leona
Published: August 2022

This paper reports on the implementation of a collaborative approach to STEAM (Science, Technology, Engineering, Arts, and Mathematics) education within the context of a college of education and an elementary school in Ireland. The project is novel in that it explores a transdisciplinary approach of supporting STEAM education in a school, using data science and an Internet of Things (IoT) based Environment Monitoring System. This case study contributes to an emerging field of research within STEAM that is informed by practice with emphasis placed on the value of collaboration and transdisciplinary pedagogical approaches. The multi collaborators included lecturers from a college of education with expertise in STEM and Visual Arts education, creative professionals (artists, scientists, and architects), teachers, students, and children. Encompassing all the mentioned stakeholders was important and placed transdisciplinarity at the core of the learning. Qualitative data was collected using questionnaires, focus groups and interviews to research how the participants interpreted their experiences and what meaning they attributed to their experiences. It was found that a program of STEAM education integrating new and emerging technologies with data science and the IoT can promote and encourage the delivery of a transdisciplinary model of STEAM education and the overall reconceptualization of how individual subject areas are taught at elementary level. Innovative data capturing technologies, exploring real-life data within their local educational contexts can positively impact children and teachers’ knowledge and skills in STEAM supporting the development of artistic concepts, engineering habits of mind, imagination, and creativity. The success of the project can be attributed to the collaboration between various stakeholders in the design and implementation of the project. This paper has provided valuable insights into teachers’, scientists’, and artists’ perspectives, children’s experiences, and the role of innovative technology in STEAM education.