bluuebunny/crossref_metadata_2025 huggingface dataset:
Critical Analysis of Neuronal Cell and the Mouse Bioassay for Detection of Botulinum Neurotoxins
Authors: Pellett Sabine , Tepp William H. , Johnson Eric A.
Published: December 2019

Botulinum Neurotoxins (BoNTs) are a large protein family that includes the most potent neurotoxins known to humankind. BoNTs delivered locally in humans at low doses are widely used pharmaceuticals. Reliable and quantitative detection of BoNTs is of paramount importance for the clinical diagnosis of botulism, basic research, drug development, potency determination, and detection in clinical, environmental, and food samples. Ideally, a definitive assay for BoNT should reflect the activity of each of the four steps in nerve intoxication. The in vivo mouse bioassay (MBA) is the ‘gold standard’ for the detection of BoNTs. The MBA is sensitive, robust, semi-quantitative, and reliable within its sensitivity limits. Potential drawbacks with the MBA include assay-to-assay potency variations, especially between laboratories, and false positives or negatives. These limitations can be largely avoided by careful planning and performance. Another detection method that has gained importance in recent years for research and potency determination of pharmaceutical BoNTs is cell-based assays, as these assays can be highly sensitive, quantitative, human-specific, and detect fully functional holotoxins at physiologically relevant concentrations. A myriad of other in vitro BoNT detection methods exist. This review focuses on critical factors and assay limitations of the mouse bioassay and cell-based assays for BoNT detection.
Revitalizing the Successful Past in the North: Narratives of Change in the Peripheral Post-Industrial City of Kajaani, Finland
Authors: Häyrynen Simo , Semi Jussi
Published: December 2019

Finding a new destination for declining industrial communities is a common European trend, wherein local, national and EU interests are intertwined and sometimes contested. New meaning is sought, among other things, in economics, political activity, and images of the past. This article analyzes local development narratives in the case of the “northern periphery”. This paper highlights how the shrinking town of Kajaani, Finland, reacts to the state’s changing role in regional industrial strategies by comparing different local interpretations of future expectations. The research material comprises interviews, city strategies, and editorials from a local newspaper. This paper suggests that the previously dominant narrative of decentralization still holds sway in the minds of the local advocates. However, it is flavored by the narrative of the knowledge-based economy forming three interrelated local narratives: the narrative of the small town; the narrative of closure; and the narrative of traction. The analysis shows that a northern model city of former industrial policy is seeking to reform and develop its original strengths. However, strong links to previous doctrines of state regional policy still frame the potential of local interpretations and make them specifically Nordic development narratives.
Chimeric Capsid Proteins Impact Transduction Efficiency of Haploid Adeno-Associated Virus Vectors
Authors: Chai Zheng , Zhang Xintao , Dobbins Amanda Lee , Frost Ellie Azure , Samulski R. Jude , Li Chengwen
Published: December 2019

Our previous studies have demonstrated that haploid AAV vectors made from capsids of two different serotypes induced high transduction and prevented serotype-specific antibody binding. In this study, we explored the transduction efficiency of several haploid viruses, which were made from the VP1/VP2 of one serotype and VP3 of another compatible serotype. After systemic injection of 2 × 1010 vg of AAV vectors into mice, the haploid AAV vectors, composed of VP1/VP2 from serotypes 8 or 9, and VP3 from AAV2, displayed a two to seven-fold increase in liver transduction compared with those of parental AAV2 vectors. Furthermore, a chimeric AAV2/8 VP1/VP2 with N-terminus of VP1/VP2 from AAV2 and C-terminus (VP3 domain) from AAV8 was constructed, and produced the haploid vector 28m-2VP3 with AAV2 VP3. The haploid 28m-2VP3 vector showed a five-fold higher transduction than that of the vectors composed solely of AAV2 VPs. Remarkably, the 28m-2VP3 vectors also induced a significant increase in transgene expression compared to the vectors composed of AAV8 VP1/VP2 with AAV2 VP3. The results suggest that the difference in the VP1/VP2 N-terminal region between AAV2 and AAV8 may allow better “communication” between the VP1/VP2 N-terminus of AAV2 with its cognate VP3. Similarly, the haploid vectors, VP1/VP2 from serotypes 8 or 9 and VP3 from AAV3, achieved higher transductions in multiple tissue types beyond typical tropism compared with those of AAV3 vectors. Consistently, higher vector genome copy numbers were detected in these tissues, indicating that an incorporation of non-cognate VP1/VP2 might influence the cellular tropism of the haploid vectors. However, there was no significant difference or even decreased transductions when compared with those of parental AAV8 or AAV9 vectors. In summary, these studies provide insight into current development strategies of AAV vectors that can increase AAV transduction across multiple tissues.
Treatment of Harvest Mite Infestation in Dogs Using a Permethrin 54.5% and Fipronil 6.1% (Effitix®) Topical Spot-On Formulation
Authors: Lecru Line-Alice , Combarros Daniel , Castilla-Castaño Eloy , Navarro Christelle , Cadiergues Marie
Published: December 2019

Background—The study aims to assess the efficacy of a permethrin 54.5%-fipronil 6.1%-based spot-on solution in dogs naturally infested with Neotrombicula in an open-label controlled study. Methods—Ten naturally infested dogs received one drop per affected site on day (D) 0, and on D14, the rest of the pipette was applied on the skin between the shoulders. Five dogs served as sentinels. Parasite score (0–3), skin lesions (0–4), and investigator pruritus scale (0–4) were assessed on D0, D1, D14, and D28. Results—No treated dogs developed adverse reactions. Parasite score of sentinel dogs was maintained between 1.8 (D0, D1, and D28) and 2.2 (D14). In treated dogs, D0 parasite score was 2.4. It was significantly reduced from D1 (0.5; p < 0.002) to D28 (0.1; p < 0.002). The lesion score was 2.9 on D0 and D1; it was significantly reduced on D14 (0.6; p < 0.002) and D28 (0.1; p < 0.002). Similarly, investigator pruritus scale (D0, 2.2) scores significantly decreased on D14 (0.4; p < 0.004) and D28 (0.2; p < 0.002). Conclusions—The combination permethrin-fipronil appears to be well-tolerated, rapidly and durably effective in the control of localized canine harvest mite infestation.
Green Water on A Fixed Structure Due to Incident Bores: Guidelines and Database for Model Validations Regarding Flow Evolution
Authors: Hernández-Fontes Jassiel V. , Esperança Paulo de Tarso T. , Graniel Juan F. Bárcenas , Sphaier Sergio H. , Silva Rodolfo
Published: December 2019

This paper presents a two-dimensional experimental study of the interaction of wet dam-break bores with a fixed structure, regarding the evolution of the incident flows and the resultant green water events on the deck. The study employs image-based techniques to analyse flow propagation from videos taken by high-speed cameras, considering five different shipping water cases. The features of small air-cavities formed in some green water events of the plunging-dam-break type were analysed. Then, the spatial and temporal distribution of water elevations of the incident bores and green water were investigated, providing a database to be used for model validations. Some guidelines for the selection of the freeboard exceedance, which is of relevance for green water simulations, were provided. Finally, the relationship between the incident bore and water-on-deck kinematics was discussed. The proposed study can be used as a reference for performing simplified and systematic analyses of green water in a different two-dimensional setup, giving high-resolution data that visually capture the flow patterns and allow model validations to be performed.
Variation of the Water Level in the Yangtze River in Response to Natural and Anthropogenic Changes
Authors: Liu Jinxin , Deng Jinyun , Chai Yuanfang , Yang Yunping , Zhu Boyuan , Li Sixuan
Published: December 2019

The water level in the Yangtze River has significantly changed due to the effects of varied precipitation and dam operations, which have exerted significant effects on irrigation, navigation, and ecosystems. Based on the measured data and the proposed calculation method, we analyzed the adjustment mechanisms of the seasonal water level in the whole Yangtze River. The results were as follows. During the dry season, the rising precipitation and dam operation both increased the water level in the upper reaches and in the reaches from the Jianli to Datong stations during 1981–2014. Moreover, dam operations were the dominant factor (except at Datong station). In the reaches from the Yichang to Shashi stations, dam operations are the reason for the reduction of the measured water level in the dry season, while the rising precipitation had an opposite influence. During the flood season, dam operations helped to reduce the water level from the upper reaches to the estuary during 1981–2014, while climate variation stresses adversely affected the entire river basin. In the reaches between the Luoshan and Jianli stations, climate variation is the dominant factor for the increased water level during the flood season, while dam operation is the reason for the reduced water level at the other six hydrological stations.
Microbial contamination in food, food- handlers’ hands and surfaces and evaluation of contamination sources by the similarity between isolates
Authors: ERDOĞAN Metin , PAMUK Şebnem
Published: December 2019

Food can be contaminated with surfaces and food
workers during chopping, shredding and serving. Pathogenic microorganisms are
transmitted by direct contact with food or indirectly with airborne particles.
The aim of this study was to determine the prevalence and the relationship
between pathogenic microorganisms isolated from food, kitchen equipment and
foodhandler’s hands. A total of 212 microbiological samples were collected from
surfaces, foods and food handlers’ hands at different six canteens inside of the
Afyon Kocatepe
University campus during the period 2017-2018. Following biochemical tests,
identification of Staphylococcus species
were performed from a specific region of 23S rRNA gene. The genetic
relationships between totally 25 Staphylococcus
spp. and Proteus mirabilis isolates
were determined. S.epidermidis was
detected in two samples from knife handle (5%), nine samples from hands (20%)
and in one of food sample (1%), too. S.aureus
was found to be existed in one sample from hands (2.2%), two samples of soujouk
(2%) and in one sample pancakes (3%) obtained from the university canteens.
Besides from one of food sample (1%) S.sciuri,
from one of hand sample (2.2%) S.haemolyticus
and one of the food samples (1%) S.saprophyticus bacteria were identified. As a
result, foods, food preparation surfaces and foodhandler’s hands were
contaminated with microorganisms in canteens and they were similar/same to each
other. Also, considering the number of isolates, the highest of contamination
is the hands of food-handler.
Conditions de cristallisation et évolution paragénétique d'une charnockite hercynienne : le complexe granulitique d'Ansignan (Massif de l'Agly, Pyrénées-Orientales)
Authors: Andrieux Pascal
Published: December 2019

L'intrusion charnockitique d'Ansignan (massif de l'Agly, Pyrénées-Orientales) comporte des paragenèses granulitiques à orthopyroxène ± grenat + plagioclase + feldspath K + biotite + quartz et, dans les roches basiques associées, à orthopyroxène + clinopyroxène + plagioclase ± biotite + quartz. Les calibrations effectuées sur les couples grenat-biotite, grenat-orthopyroxène, orthopyroxène-clinopyroxène et clinopyroxène-plagioclase fournissent des indications sur les pressions et les températures de stabilité des assemblages primaires : Ils auraient cristallisé dans les conditions du faciès granulite de pression intermédiaire entre 7 et 800 °C pour 6 (± 1) kbar de pression totale, en équilibre avec l'encaissant gneissique (gneiss de Caramany) à grenat + cordiérite + feldspath K + plagioclase + biotite ± sillimanite + quartz.

Les réactions :

OPX + FK + Eau → Bi + Qtz

Gt + FK + Eau → Bi + Cdt + Qtz

Gt + Cdt + FK + Eau → Bi + Si.Al + Qtz

observées dans les unités granulitiques, permettent de définir une rétromorphose marquée par une diminution dans le temps des conditions de pression et de température.

Sa situation actuelle, au sein d'une série métamorphique caractérisée par des assemblages de basse pression (Fonteilles, 1970, 1976) suggère par conséquent un changement de niveau structural de cet ensemble catazonal. Cette ascension est interprétée comme le résultat d'un processus de diapirisme basicrustal.
Estágio Docência: uma atividade do Programa de Pós-graduação em Educação da Universidade Tuiuti do Paraná
Authors: Dos Santos Amaral Filho Fausto , Almeida Veiga Adriana , Baumgarten Gebert Angélica , Romaniuk Cláudia
Published: December 2019

O artigo é resultado do estágio docência de três mestrandas em educação na Universidade Tuiuti do Paraná, assim é um relato de caso, embasado teoricamente por meio de pesquisa bibliográfica. O estágio docência é uma atividade ofertada pela Universidade Tuiuti do Paraná que objetiva a preparação para a docência. A articulação e a contextualização dos princípios teóricos da formação dos pós-graduandos com a vivência em sala de aula aproxima a teoria com a prática. Aos discentes são oportunizadas experiências formativas sob a supervisão de um professor com atividades dirigidas para alunos da graduação. Neste caso,a experiência de estágio das três alunas se realizou em duas disciplinas do Curso de Pedagogia: Filosofia da Educação e Filosofia da Educação Contemporânea. Com base em uma perspectiva formativa concluíram o estágio docência acarretando subsídios para reflexões e socialização da experiência vivenciada. Para tanto, como fundamentação teórica serão abordados autores como: Martins; Romanowski; Cartaxo (2014), Boas, Carrieri (2013) e Franco (2012). Após a conclusão deste estudo, recomenda-se a inserção da atividade de estágio docência nos cursos de pós-graduação como perspectiva de promoção de avanços em prol da formação docente.
Padronização e redução de custos: o caso da unificação de shelf life de embalagens plásticas frigorificadas
Authors: Pauletti Dadiane , Aralde Regiane , Feliciano Jorge Marcos , De Lima Miguelangelo Geimba
Published: December 2019

A padronização de produtos de origens diversas não impacta tão somente em agilidade e controle de operações, mas também na identificação e eliminação de custos ocultos. Seguindo esta orientação, neste trabalho foi realizado um estudo de caso em uma Multinacional Brasileira do Ramo Alimentício em que foram levantados e posteriormente padronizados os prazos de validade (shelf life) das embalagens plásticas frigorificadas. Os resultados indicaram que a gestão de estoques de diversos prazos de validade para as mesmas categorias de embalagens de fornecedores distintos, causavam transtornos no controle de estoques e desperdícios com descartes indesejados de itens vencidos, aumentando o custo final dos produtos acabados.
Análise entoacional na Amazônia: um estudo comparativo interdialetal das variedades do português falado em Mocajuba e Cametá (PA)
Authors: Costa Maria Sebastiana da Silva , Cruz Regina Célia Fernandes
Published: December 2019

Este trabalho compreende um estudo comparativo das descrições prosódicas prévias sobre as variedades de Mocajuba e Cametá (PA) no seio do projeto AMPER-POR (COSTA, em andamento). Visa-se à descrição do comportamento entoacional de sentenças nas modalidades declarativa neutra e interrogativa total. Os parâmetros acústicos de frequência fundamental (doravante F0), duração e intensidade foram foco de análise. Os procedimentos metodológicos adotados foram previamente estabelecidos pelo projeto AMPER-POR (CRUZ et al., 2012). Os movimentos melódicos das curvas de F0, nas modalidades frasais interrogativas e declarativas, para a variedade de Cametá, registraram menos variação intersilábica de F0, em relação a Mocajuba, indicando, portanto, essa variedade como tendo maior musicalidade, nos três tipos de acento lexical. Desta forma, apenas os resultados concernentes à variação melódica de F0 da variedade falada em Mocajuba assemelha-se com padrões entoacionais encontrados para outras regiões brasileiras, mais precisamente para o Norte e Nordeste brasileiro conforme descrito por Moraes (2003 apud SILVA e CUNHA, 2012, p. 10) e Silva e Cunha (2012). O parâmetro acústico de duração apresentou uma distinção dialetal significativa, posto que os dados de Cametá registraram sílabas mais longas, em relação a Mocajuba. A intensidade não apresentou variação significativa entre os dialetos estudados.
A variação linguística nos livros didáticos do ensino fundamental II
Authors: Pedreira Carlos Wilson de Jesus , Pedrosa Juliene Lopes
Published: December 2019

Neste capítulo, analisa-se o tratamento da variação linguística em dois livros didáticos de Língua Portuguesa do Ensino Fundamental II. Para realização desta pesquisa, foram selecionadas como material de investigação as obras Jornadas.port de Dileta Delmanto e Laiz B. de Carvalho e Singular &  plural:  leitura, produção e estudos de linguagem de Laura de Figueiredo, Marisa Balthasar e Shirley Goulart - ambas  indicadas pelo Programa Nacional do Livro Didático,  PNLD, em 2012 – com o objetivo de verificar e avaliar como os livros didáticos supracitados tratam o fenômeno da variação linguística. A pesquisa parte de um trabalho bibliográfico/documental, ou seja, coleta de dados nos livros didáticos sobre a inserção da variação no ensino, observando o tratamento dado à variação, com base nos textos de alguns estudiosos como Bagno (2002, 2003, 2007), Bortoni-Ricardo (2004, 2005, 2008), Faraco (2008) e os PCNs (BRASIL, 1997, 1998). Como os livros didáticos foram aprovados pelo processo de avaliação do PNLD, isso significa que são considerados satisfatórios ao que se propõem. A análise conclui que os livros didáticos analisados apresentam deficiência na apresentação e tratamento da variação linguística, dando pouca contribuição para que o aluno assuma uma posição teórica, crítica e investigativa a respeito de regras variáveis.
Variação linguística e sua inter-relação com letramento
Authors: Costa Jaciara Carvalho , Carneiro Mônica Fontenelle
Published: December 2019

Associando a variação linguística aos processos de letramento, levantamos a problemática de como esses dois temas se relacionam com a fala de pessoas de baixa escolaridade em ambientes industriais com exigências de práticas letradas. O objetivo esteve em analisar realizações de concordância verbal em 3ª pessoa (CV3) de trabalhadores da cidade de São Luís, MA, de baixa escolaridade. Como hipótese, estabeleceu-se, inicialmente, que a vivência em espaços laborativos letrados interfere no aspecto linguístico de concordância verbal desse trabalhador. Ancoramo-nos em trabalhos de estudiosos como Street (2014 [1995]), (1991); Kleiman (1995), Kleiman e Assis (2016), Labov (2006[1968]; 2008[1972]), Weinreich, Labov e Herzog (2006 [1968]), Lucchesi (2015a, 2015b), Bortoni-Ricardo (2011, 2014), Mollica (2014) e Castilho (2016). Desenvolvida a partir do método sociolinguístico, trata-se de pesquisa quali-quantitativa cujo corpus foi extraído da fala dos indivíduos, a partir de aplicação de eventos discursivos, obtendo-se cinquenta e dois registros para análise. Como resultado, obtivemos que mais de cinquenta por cento da materialização linguística da CV3 realizada pelos falantes dá-se no padrão da norma culta do Português Brasileiro, destacando-se o uso do sujeito pronominal não explícito e da saliência fônica com alteração da qualidade da vogal final como um dos principais recursos linguísticos usados por esses falantes.
Penggunaan Mabādī ‘Asyroh dalam Pembelajaran Biologi untuk Meningkatkan Motivasi dan Hasil Belajar
Authors: Setiawan Adib Rifqi
Published: December 2019

Mabādī ‘asyroh adalah sepuluh indikator yang dipakai untuk mengidentifikasi setiap disiplin ilmu. Penelitian ini bertujuan untuk menerapkan mabādī ‘asyroh dalam pembelajaran biologi untuk meningkatkan motivasi dan hasil belajar siswa. Data diperoleh menggunakan metode weak-experimental dengan desain one-group pretest-posttest terhadap sampel sebanyak 41 siswa sekolah menengah yang dipilih melalui teknik convenience sampling di Kabupaten Kudus. Peningkatan ditentukan berdasarkan nilai gain yang dinormalisasi terhadap hasil pretest-posttest menggunakan Science Motivation Questionnaire (SMQ) untuk mengukur motivasi belajar dan tes tipe uraian dengan keandalan sebesar 0,810 sebagai pengukur hasil belajar siswa kemudian dikaitkan menggunakan Pearson r. Hasil penelitian menunjukkan bahwa motivasi belajar mengalami peningkatan dalam kategori tinggi dengan nilai 0,809 dan hasil belajar mengalami peningkatan dalam kategori tinggi dengan nilai 0,709, yang keduanya memiliki kaitan positif sebesar 0,840 setelah diterapkan mabādī ‘asyroh ke dalam pembelajaran biologi. Melalui penelitian ini terungkap bahwa mabādī ‘asyroh bisa dipakai dalam pembelajaran biologi untuk meningkatkan motivasi dan hasil belajar siswa.
MANAGING THE SURFACE PROPERTIES OF MATERIALS OF DISPLAY TECHNOLOGY BY MEANS OF TREATMENT IN ATMOSPHERIC DISCHARGE PLASMA
Authors: Zaporozhchenko Y. V. , Kotov D. A. , Aksyuchits A. V. , Osipov A. N. , Paceev S. V.
Published: December 2019

The results of research the surface of single-crystal silicon, glass, and stainless steel after processing in a plasma at atmospheric pressure are presented. It has been experimentally proved that after processing, the adhesive properties of the surface of materials are significantly improved.
GRADIENT ALIGNMENT MATERIALS WITH DIFFERENT PHOTOSENSITIVITY FOR TUNABLE POLARIZATION-INDEPENDENT LIQUID CRYSTAL LENS
Authors: Bezruchenko V. S. , Muravsky A. A. , Murauski A. A. , Stankevich A. I. , Mahilny U. V.
Published: December 2019

The development of electrically tunable liquid crystal (LC) lenses is perspective and promising for a wide range of applications, for example, for imaging system, pico projectors, optical zoom systems, ophthalmology applications and other. Of particular note is the development of polarization-independent LC lenses, as eliminates polarizers from application devices that reduce the efficiency of light transmission through optical systems. Alignment benzaldehyde photosensitive materials, capable of changing the pretilt angles of nematic LC from 90 to 0 ºС in a controlled manner under UV exposure are developed. The anisotropy of the benzaldehyde alignment layers is generated by a two-stage treatment consisting of uniform rubbing with a cloth and subsequent non-polarized UV exposure. Inhomogeneous UV exposure of uniformly rubbed alignment layers allows formation of refractive index gradient inside the LC cell. The concept of tunable polarization-independent self-aligned LC lens based on gradient pretilt angle alignment materials with different photosensitivity is demonstrated. Self-alignment of two polarization-dependent sub-lens is achieved due to a single UV exposure act of two alignment layers, which are located on the same piece of glass on both sides, forming one common optical axis for a polarization-independent LC lens. The independence of the polarization of LC lenses is achieved by setting the azimuthal rubbing direction of the alignment layers of two polarizationdependent LC lenses perpendicular to each other. The sub-lens cells have uniform cell gap and are independently controlled using low-voltage driving. Devices based on gradient benzaldehyde alignment materials can be used in many modern optical and photonic devices.
ELECTRO-OPTICAL SWITCHING OF THE MAIN OPTICAL AXIS OF A FERROELECTRIC LIQUID CRYSTAL SPIRAL NANOSTRUCTUREIN A PLANAR-ORIENTED DISPLAY CELL
Authors: Pozhidaev E. P. , Tkachenko T. P. , Kuznetsov A. V. , Kompanets I. N.
Published: December 2019

In a known display cell with the nematic liquid crystal (NLC) and interdigital electrodes on one of the glass substrates, the “In-Plane Switching” (IPS) mode is implemented, in which the NLC main optical axis reorients in a plane parallel to substrates, providing the most correct color reproduction at different angles view, up to 178 ° horizontally and vertically. Unfortunately, the creation of interdigital metal electrodes complicates and increases the technological process cost and causes a decrease in image contrast. At the same time, experimental results and calculations based on classical electro-optics of crystals indicate that electrooptical switching in the IPS mode is a natural and intrinsic feature of a conventional (with continuous electrodes) display cell with a planar-oriented layer of the ferroelectric liquid crystal (FLC), in which the effect of the deformed (by the electric field) helix FLC nanostructure is realized (DHF effect). In such a cell, the reorientation of the main optical axis under the influence of a weak electric field also occurs in the substrate plane if the FLC has a small pitch (about 100 nm or less) and a large tilt angle of molecules in the layer (about 38 ° or more). The dependences of the FLC cell light transmittance measured in this work, confirmed the achievement of the IPS electro-optical mode in the DHF FLC cell; moreover, the light modulation frequency was 1 kHz. Thus, while maintaining all the advantages of the IPS mode known in NLC, its implementation in FLC allows additionally obtaining technological advantages and multiple increase in modulation frequency.
PHOTOTUNABLE SELECTIVE REFLECTION OF CHOLESTERIC LIQUID CRYSTALS
Authors: Chepeleva D. S. , Yakovleva A. S. , Murauski A. A. , Kukhta I. N. , Muravsky A. A.
Published: December 2019

The dependence of the helical pitch of a cholesteric liquid crystal based on a composite photosensitive chiral dopant (cChD) on the intensity of light irradiation was studied. The transmission spectra and the selective reflection spectra of cholesteric liquid crystal cells were measured. The concentration of the cChD additive is calculated, so that the peak of selective reflection and its rearrangement occurs in the visible range of the electromagnetic radiation spectrum (380-780 nm). The possibility of photo-control by shifting the peak of the selective reflection of the cChD additive was studied, when exposed to LEDs with wavelengths of 365 nm and 450 nm, while reducing or increasing the intensity, a change in the spiral pitch was observed. Depending on the light intensity, part of the molecules of the chiral additive containing the azo group underwent isomerization, i.e. molecules in the trans-form passed to the cis-form, which led to a spectral shift of the selective reflection peak. If a small intensity of the 365 nm LED was applied, then some of the molecules were forced to transition from the trans- to the cis-form, and then, when illuminated with a 450 nm LED, from the cisto the trans-form. After reversible rearrangement, the properties of cholesteric liquid crystal changes due to interaction with light, because under the influence of light, the equilibrium ratio of the trans- and cis-isomers of the molecules of the substance changed, which macroscopically changed the torsion force of the chiral additive. Using two LEDs of 365 nm and 450 nm with different emission spectra, a reversible control of the cChD selective reflection peak in the visible range was obtained. The maximum displacement occurred at approximately 145 nm.
LED ULTRAVIOLET EXPOSURE UNIT WITH ADJUSTABLE EXPOSURE TIME
Authors: Cheliapin A. E. , Begunov P. S. , Trofimov Y. V. , Zhavnerko G. K.
Published: December 2019

The possibilities of improving the quality of the topological pattern in the exposure of thick-film photoresists due to uniform irradiation with ultraviolet light-emitting diodes are investigated. The results of an experimental study of the developed LED ultraviolet photolithographic irradiator with a controlled exposure time are presented.
AUTOELECTRONIC CATHODES BASED ON ARRAYS OF NIOBIUM-OXIDE COLUMNAR NANOSTRUCTURES FOR FIELD EMISSION DISPLAYS
Authors: Gorokh G. G. , Taratyn I. A. , Pligovka A. N. , Lazavenka A. A. , Zakhlebayeva A. I.
Published: December 2019

The article discusses the prospects of creating controlled field-effect cathodes based on arrays of columnar oxide niobium nanostructures for field emission displays. Geometrical models of field-emission cathodes and vacuum elements have been developed and investigated. The distribution of the electric field in the vacuum device at various distances between the cathode and the anode, the applied voltages between them, the shape and microgeometry of the cathodes were obtained. The optimal geometric parameters of nanostructured autoelectronic cathodes and matrices of these were calculated based on the simulation. The technological route has been developed for the production of autoelectronic cathode matrices based on arrays of niobium-oxide columnar nanostructures formed by electrochemical anodization of Al/Nb thin-film system. The samples of controlled arrays of autoelectronic cathodes were fabricated and the current-voltage characteristics with interelectrode gap of 2, 5 and 10 μm in various electric modes with change in the electric field strength from 3 to 85 V/μm were studied. At 2 μm gap between the anode and cathode, the emission occurs at minimum threshold voltages, but it is characterized by limited current values. The increasing in the interelectrode gap allows rising the emission currents, however, the threshold voltages increase. In the pulsed mode, the large emission currents are achieved. The threshold voltage of autoelectronic cathode matrices with interelectrode gap of 5 μm was 9.16 V, the maximum currents reached 350 μA at voltage of 22.5 V. In the pulsed mode, the emission arose at 11.06 V, the maximum current reached 1500 μA at 40 V.
MICRODISPLAY STRUCTURES BASED ON ORGANIC GREEN LIGHT EMITTING DIODES USING THERMALLY ACTIVATED DELAYED FLUORESCENCE MATERIALS
Authors: Grachev O. A. , Kudryashova E. F. , Usov N. N.
Published: December 2019

The aim of the work is to develop a new highly efficient light-emitting structure of microdisplays based on organic light-emitting diodes (OLED) for the modernization of the microdisplayes MDO 02 of the mass production. It is also intended to use the new OLED structure in subsequent developments of new series of microdisplays, including a green glow. Сomplete microdisplay element consists of а active matrix and OLED structure, which is a set of layers of low molecular weight organic materials. The active matrix of the microdisplay MDO 02 contains 800×3(RGB)×600 pixels for the full-color version and 800×600 pixels for the monochrome version. Microdisplay MDO 02 has the following characteristics: the nominal brightness of the full-color glow is 140 cd/m2, the monochrome glow is – 560 cd/m2, the unevenness of the brightness is not more than 15 %, the contrast in relative units is not less than 100:1, the power consumption is not more than 450 mW, the operating time on refusal not less than 5000 hours. To improve these characteristics, it is proposed to use OLED structure, including materials with thermally activated delayed fluorescence (TADF). Materials with TADF have a much simpler synthesis scheme, an expanded selection of starting components and do not need expensive rare and rare-earth metals, which are used for the synthesis of phosphorescent materials. A structure with high light (external quantum yield up to 26.2 %) and electrical parameters with the described dopant synthesis process was selected from a number of OLED structure. This structure consists of four organic layers: hole-injection, hole-transport, emission and electron-transport. As a dopant for the emission layer, material aICTRZs based on indocarbosol derivatives was used. The dopant aICTRZs was synthesized by us according to the proposed synthesis method. The characteristics of this structure were evaluated using an ITO / TAPC (30 nm) / TCTA (10 nm) / CBP (25 nm) / Bphen (30 nm) / LiF (0.5 nm) / Al (150 nm). Although the optical characteristics of such an LED did not reach the declared values, they showed quite good results. As a result, such an OLED structure can be used as an initial one and, with its further development, one can count on stable and high results of the optical and electrical characteristics of MDs.
TUMOR DE MAMA FILOIDE MALIGNO COM COMPONENTE SARCOMATOSO: REVISÃO INTEGRATIVA
Authors: de Lima Caldas Gervásio Liliane , Emanuele Garrido Torres Thais , de Lira Silva Macerlane , Vilar de Assis Elisângela , do Nascimento Andrade Feitosa Ankilma
Published: December 2019

Introdução: o tumor filoide (TF) da mama é uma neoplasia fibroepitelial, responsável por menos de 1% dos tumores de mama. É o único tumor benigno da mama em 80% dos casos, capaz de malignar-se, o que ocorre em até 20% dos casos. A mama esquerda é mais acometida. Seu diagnóstico geralmente é clínico, no entanto, suas características e comportamento clínico são imprevisíveis. Diante disso, o diagnóstico é estabelecido por meio de mamografia, ultrassonografia mamária e biópsia. O tratamento baseia-se na cirurgia, dependendo da extensão, tipo histológico e diferenciação do tumor. Objetivo: realizar uma análise da literatura vigente acerca do tumor filoide maligno com componente sarcomatoso, levando em consideração a importância do diagnóstico precoce correto, possíveis métodos diagnósticos, identificar as limitações e chances de sucesso e fatores que podem agravar o quadro. Metodologia: Trata-se de uma revisão integrativa da literatura, onde se realizaram a seleção e a identificação da bibliografia dentro da temática alvo, utilizando-se artigos científicos em bases de dados publicados entre os anos de 2015 e 2018. Como base para a realização do estudo, foram selecionados sete artigos, encontrados nas bases de dados SciELO, LILACS e PubMED, onde um trata-se de um estudo retrospectivo, um estudo quantitativo, duas revisões integrativas e três estudos de caso. Ressalta-se a carência de artigos em português abordando a temática em questão. Conclusões: diante do exposto, constata-se que a fragilidade no diagnóstico, pela indisponibilidade de uma rede de atenção e de equipamentos de saúde, predispõe a um pior prognóstico, especialmente pelo retraso no diagnóstico, que, quando precoce, influi positivamente para celeridade no tratamento e melhoria do prognóstico. Palavras chaves: Câncer de mama. Componente sarcomatoso. Filoide.
DYNAMICS OF SUBJECT-OBJECT INTERACTIONS IN THE TRANSLATION SPACE
Authors: Kushnina L.V. , Pogorelaya N.G.
Published: December 2019

The article is based on two models of texts’ semantic analysis: the synergetic model of translation named as “translation space” conception and the extralinguistic model of scientific text defined as epistemic situation. The short of the approach is that translator studies both objective, - textocentric, -and subjective, - subject oriented, - meanings of the text; their formation can be traced in the fields of the translation space. At that, subject-object interactions characterize also an epistemic situation that is formed by ontological, methodological and axiological features of source and target texts included in the orbit of the translation space. The result of dynamical interaction of all textual meanings and their synergy is a harmonious text of translation determining reciprocal understanding of the author and the recipient that belong to different lingo cultures.
THE STRUCTURAL FEATURES OF ENGLISH SI SYSTEM EPONYMS
Authors: Buran A.L. , Solodovnikova O.V. , Ryabova E.S. , Fedorinova Z.V.
Published: December 2019

The paper analyzes the structural features of the English-language eponyms of the International System of Units, which have not been studied in linguistic works. Structural features are understood as belonging to certain parts of speech (nouns, adjectives, etc.) and composition features (such as one-element, two-element, three-element and multicomponent eponyms). The aim of this study is to analyze the structural features of English-language terminological units, derived from proper names (joule, pascal, etc.) in the International System of Units. The research material includes 150 SI terminological units presented in English. Finally, regarding the achieved results, it can be concluded from the research that the predominance of two-element eponymic models in the terminological system of SI tends to express scientific concepts laconically.
THEORETICAL AESTHETICS OF L. TOLSTOY AS A MANIFEST OF ANTI-MODERNISM
Authors: Darenskiy V.Yu.
Published: December 2019

The article is devoted to the interpretation of L. Tolstoy’s theoretical aesthetics as a part of the literary process - as a kind of “manifesto” directed against the emerging modernism (anti-traditionalism). The main components of L. Tolstoy’s aesthetic theory, which are interpreted as worldview principles that most effectively oppose the “death of art” (V. Weidle) in the “postmodern situation” and anti-artistic requirements of the “consumer society”, are considered. The aesthetic concept of L. Tolstoy is interpreted as a strategy to combat the imposition of perverted tastes and immorality in art. The main components of this theory and their interrelation are allocated. L. Tolstoy's aesthetics is considered as an important value basis of modern art education.
THE PHENOMENON OF REPLACEMENT OF VOICEd-VOICELESS CONSONANTS IN RUSSIAN POETRY (BY THE EXAMPLE OF EXACT RHYMES IN LERMONTOV’s EARLY LYRICS (1828-1832))
Authors: He Fan
Published: December 2019

The aim of the article is to identify the phenomenon of the replacement of voiced-voiceless consonants in Russian poetry and to study its use for exact rhymes in Lermontov’s early lyrics. The main content of the article is the analysis of replacement of voiced-voiceless consonants as a phonetic phenomenon and a corresponding method of rhyming in Russian poetry, the history of its employment in Russian poetry. The analysis helps to reveal the conditions of the use of replacement of voiced-voiceless consonants in exact rhymes of Lermontov’s early lyrics. In the article, the new materials and statistical data of different kinds of rhymes in Lermontov’s early lyrics are summarized. The article is directed to the specialists in the history of Russian literature and the researchers of Lermontov’s works in general.
THE SOPHIAN MYTH IN THE NOVEL BY V.P. ASTAFYEV “THE SHEPHERD AND THE COWGIRL”
Authors: Ibatullina G.M. , Alekseenko M.V.
Published: December 2019

The article discusses the figurative and semantic paradigms of the sophiological myth in the story by V.P. Astafyev “The Shepherd and the Cowgirl”. The image of the main character of the story Lucy is endowed with a number of symbolic connotations and has a complex archetypal structure. The Sophian archetype is represented here in its two invariants: the Christian and the Gnostic; the keys to understand the heroine are also the Theotokos archetype, the archetypes of the Virgin, the Beloved, the Mistress, Psyche, and the Kabbalistic archetype Shekhinah, which is closely related to the original image of Sophia. The Sophian model of a feminine principle is reflected both in the personality-psychological, spiritual and moral characteristics of the heroine, and in the logic of the image of her fate. The study leads to the conclusion that the mythologeme of Sophia in its different modes (Sophia the Wisdom of God, Sophia the Gnostic, Eternal Femininity) in the paradigm of Lucy's image is one of the semantic dominants; in addition, in the mythopoetic sign system of the work, the Sophian archetype, along with the archetypes of Theotokos and Shekhinah, can be considered the cultural representative of the “feminine” archetype - the archetype of a Woman in its specific gender-existential aspect.
SWITCH ASSEMBLY OF THE BUILT-IN POWER SUPPLY OF A PORTABLE ELECTRONIC DEVICE
Authors: Belevskaya E. , Belevsky P. , Ozerchuk I.
Published: December 2019

This article describes schematic diagrams of automatic load switching between a battery power source and an external (network adapter) power supply. In this work, a circuit diagram of the electrical circuit of the switching power source of a portable electronic device is proposed. The algorithm of operation of the node when changing the voltage value of the battery power source is considered.
Review the Success of the Mobile Government from the Government Perspective
Authors: Azeez Noor Dheyaa
Published: December 2019

The researchers agreed on the potential of the mobile government as a new channel of communication between the government and citizens if the mobile government eliminates the traditional organizational structure of government, thus changing the way information is exchanged between them, and provide government services in a transparent manner at anytime and anywhere. For the education sector, mobile education initiatives must be successful in educational institutions must choose the appropriate technology in proportion to its infrastructure to conserve resources and reduce the stress of change.  Therefore, this research seeks to present the most important factors of success explored by researchers in their studies, using different research methods in different countries, and trying to classify these factors from the perspective of the government and citizens. The methodology used in this research is to review the literature on the success of mobile government from a government perspective, in order to determine the success factors adopted by each study, and then categorize the success factors according to the degree of their impact on the successful implementation of the mobile government. The final stage is a model proposal for mobile government success.
Efectos de aplicar la gestión de ingresos en la industria aeronáutica
Authors: Álvarez Daniela , Quiliche Renato , Chong Mario
Published: December 2019

Las aerolíneas alrededor del mundo se han visto afectadas por los desafíos de rentabilidad, participación de mercado y el comportamiento de la demanda, lo cual ha contribuido al desarrollo de la gestión de ingresos o Revenue Management. El modelo de gestión busca maximizar el nivel de ingreso en las empresas con la gestión de la demanda. La aplicación de este modelo en empresas de diversos rubros ha generado un incremento en sus ingresos anuales en orden del 4 a 5% favoreciendo oportunidades de negocio a través del desarrollo de nuevos mercados basados en la rentabilidad empresarial. La industria aeronáutica fue una de las pioneras en aplicar este modelo de gestión a nivel mundial. En esta oportunidad, el caso aplica el modelo en un mercado dinámico y con nuevas restricciones: mercado regional, vuelos cortos, tarifas desreguladas e impacto de las aerolíneas de bajo costo.
Modelo de minimización de costos asociados al consumo de agua en una industria de refrescos
Authors: Russi da Cunha Andrea , Pawlowsky Urivald
Published: December 2019

En Brasil algunas industrias hidro-intensivas vienen actuando de forma preventiva con respecto a la potencial aprobación de leyes que autoricen el cobro por uso de agua de pozos artesanales. Con el objetivo de conocer posibilidades para minimizar el impacto en los cotos, derivados del consumo de agua en las operaciones de la planta, se evaluaron alternativas para la resolución de un modelo de optimización del uso de recursos hídricos en una planta de refrescos. Específicamente se presenta en este trabajo, el resultado de la aplicación del algoritmo Generalized Bender´s Decomposition. El problema se planteó como una superestructura de distribución con el objetivo de minimizar el costo por consumo de agua en las operaciones de la planta. El modelo NLP resultante es del tipo no-convexo. La resolución utilizando descomposición permitió alcanzar sin embargo una respuesta óptima global que derivó en una estructura de distribución de agua con costos menores que la obtenida por la resolución tradicional, que sólo produjo un óptimo local con mayor costo. El problema se resolvió en Gams ® con Minos y BDM-LP, obteniendo en menos de 1 segundo los valores que conforman una estructura de distribución con el potencial de reducir los costos por consumo de agua en hasta 17,5% durante la temporada alta.
Penerapan Aspek Rasionalitas Dalam Pemilu 2019 (Studi Terhadap Tingkat Partisipasi Politik ODGJ di Kabupaten Hulu Sungai Utara)
Authors: Lesmana Budi
Published: December 2019

Election as a means of popular sovereignty is a vehicle for every citizen who has the right to choose to use his political rights and voice in choosing a leader. Without exception, based on the provisions in the legislation, every citizen can use this right.

In the implementation of the 2019 Election, the KPU strives maximally to accommodate all citizens who have the right to vote in the DPT. Repairs made many times are as an effort to increase voter involvement in elections.

One voter group that is a public concern and discourse is mental accessibility or more commonly referred to as People with Mental Disorder (ODGJ) who voted in the 2019 election. Outside the context that these mentally ill people are under forgiveness according to civil law, the constitution itself basically gives the same rights to people who have mental illness to choose. Even in the Election Law itself there is no prohibition explicitly governing this. This means that mentally ill people also have the right to exercise their right to vote. Not all mentally ill people have the awareness to choose. Of course, if there are certain conditions that are allowed to choose.

But how is the implementation of the business and rules in the field as an effort to increase voter participation by the organizers? And what is important is whether the application of direct, general, free, confidential and fair election principles can also be felt by ODGJ voters. Can their rights be used, but only choose formalities without secrecy. Don't let the voting rights of citizens with certain conditions be given an opportunity to commit fraud in the election. Fraud is detrimental to the voting rights of people who have mental disorders because it is considered easy to be cheated.

Keywords: Elections, Mental Disability (ODGJ), Voting Rights, Participation.