bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA
Authors: He Lijie , Wang Jing , Chang Dandan , Lv Dandan , Li Haina , Feng Heqiang
Published: October 2020

Objective

This article aims to investigate the effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA.

Methods

HeLa cells of cervical cancer were divided into five groups: blank control group, negative control group (miRNA-200b mimic NC), miRNA-200b mimic group, RhoA-negative control group, and RhoA overexpression group. Cells were collected 48 h after transfection. The expression levels of miRNA-200b were detected by RT-PCR. Target relationship between miRNA-200b and RhoA was verified by the dual-luciferase reporter assay. RhoA mRNA and protein expression were detected by western blot and RT-PCR methods. Flow cytometry was used to detect the apoptosis of cells in each group, and the CCK8 method was used to detect the proliferation of cells in each group. The mRNA and protein expression of Bax and cyclin D1 were detected by RT-PCR and western blot.

Results

The results of the dual luciferase reporter assay showed that RhoA was the target gene of microRNA 200b. Compared with the blank control group and the miRNA-200b mimic-NC group, the proportion of apoptotic cells increased significantly in the miRNA-200b mimic group, and the proliferation of cells was inhibited (P < 0.05). After overexpression of RhoA, the percentage of apoptotic cells decreased and the ability of cell proliferation increased significantly (P < 0.05).

Conclusion

miRNA-200b can inhibit the proliferation and promote the apoptosis of cervical cancer cells by targeting the RhoA gene.
Rheumatoid arthritis increases the risk of pleural empyema
Authors: Liao Kuang-Ming , Lin Cheng-Li , Shen Te-Chun
Published: October 2020

Background

Rheumatoid arthritis (RA) can lead to various pulmonary manifestations. Evidence shows the possible association between RA and pleural empyema.

Methods

We conducted a retrospective cohort study to investigate the risk of pleural empyema in patients with RA. The RA group (n = 29,061) included newly diagnosed adult patients between 2000 and 2012. The comparison group (n = 1,16,244) included individuals without RA at a 1:4 ratio of frequency matched by age, gender, and diagnosis year. The occurrence of pleural empyema was monitored until the end of 2013.

Results

Patients with RA had a higher risk of developing pleural empyema than those without RA (23.6 vs 1.82 per 10,000 person-years, adjusted hazard ratio = 11.0, 95% confidence interval [CI] = 8.90–13.5). Furthermore, intensive care unit admission rates of pleural empyema were 37.7% in the RA group and 37.2% in the comparison group (adjusted odds ratio [OR] = 1.02, 95% CI = 0.66−1.57). The 30-day mortality rates of pleural empyema were 11.2% in the RA group and 10.9% in the comparison group (adjusted OR = 1.01, 95% CI = 0.51−1.88).

Conclusion

Patients with RA are at a greater risk of developing pleural empyema than those without RA.
The Selfish Meme: Dawkins, Peirce, Freud
Authors: West Joel
Published: October 2020

Biologist Richard Dawkins coined the term “meme” by which he meant a unit of culture. Dan Dennett continued by defining a meme as a bunch of bits of information. This paper explores the “meme” and how it is semiotic, both in its technical sense and in its popular sense and explores how memes signify both in terms of classical semiotics and also in terms of post-structuralist thought.
Bromide hydrogen oxalate salts with the diprotonated 1,4-diazabicyclo[2.2.2]octane counterion
Authors: Ndiaye Mamadou , Diop Mouhamadou Birame , Samb Abdoulaye , Diop Libasse , Oliver Allen G. , Plasseraud Laurent
Published: October 2020

Two new salts composed of the diprotonated 1,4-diazabicyclo[2.2.2]octane (DABCO) molecule as the cations and bromide and hydrogen oxalate as the anions have been isolated and structurally characterized by X-ray diffraction analysis. The salt [DABCOH2]{[HC2O4][Br]} (1) crystallizes in the orthorhombic system, space group P212121 with a = 9.0809(7), b = 9.5156(7), c = 12.3558(9) Å, V = 1067.67(14) Å3 and Z = 4. The salt [DABCOH2]2{[HC2O4][Br]3}·H2O (2) crystallizes in the orthorhombic system, space group Pnma with a = 26.6554(17), b = 7.3711(4), c = 10.7421(7) Å, V = 2110.6(2) Å3 and Z = 4. The compounds were prepared from ethanolic solutions of [DABCOH2][HC2O4]2 (L

1
) and ZnBr2 in molar ratios of 2:1 and 1:1, respectively. The salts 1 and 2 exhibit extended hydrogen bonding networks leading to supramolecular topologies.
DO SONHO DOS INVIDENTES ÀS MIRAGENS DA MEMÓRIA
Authors: Winter Noble André
Published: October 2020

Este ensaio parte do livro “O Que os Cegos Estão Sonhando?” da escritora e crítica literária brasileira Noemi Jaffe, obra que divulga a relação de três mulheres (avó, mãe e filha) com a Shoah, narrativa que tem como cenário, a vivência e a sobrevivência a um dos campos de concentração e extermínio nazista. O livro expõe o distanciamento do acontecimento, do campo, mas igualmente nos permite dizer que quanto mais as gerações vão se afastando do fato, mais rente a ele estão. Para dizer dessas relações, investimos em um discurso que percorre por entre as questões da memória, do esquecimento e da ficcionalização mnemônica, afora a própria construção discursiva e monumental.Palavras-chave: “O que os cegos estão sonhando?”; memória e esquecimento; linguagem da/na guerra.
MEMÓRIA OU METAMEMÓRIA DAS ORIGENS?
Authors: Candau Joël
Published: October 2020

Argumento neste texto que uma conformação cognitiva do grupo nos leva a adotar um discurso mais metamemorial do que memorial quando nos referimos às nossas origens, e, sobretudo, quando as reivindicamos. Desenvolvo meus argumentos em três tempos. No primeiro analiso as possíveis causas da conformação cognitiva do grupo. Num segundo tempo, mostro que o conceito de origem é multidimensional filogeneticamente e culturalmente difuso. Disso resulta que a atribuição, reivindicação ou escolha de uma origem é arbitrária. No entanto, a conformação cognitiva do grupo nos leva a buscar origens próximas associadas a identidades contingentes ou imaginárias, ao invés de origens evolucionárias distantes que fundam nossa identidade imanente, favorecendo, portanto, o que é vago nessa noção. Em um terceiro tempo, depois de evocar três modalidades de compartilhamento de memória que não possuem o mesmo grau de plausibilidade - protomemória, memória e metamemória -, sustento que o privilégio concedido a origens associadas a identidades contingentes ou imaginárias induz mais a uma retórica frequentemente metamemorial do que um processo de memória real. Concluindo, observando a importância das metamemórias de origens em todas as sociedades humanas e sua propensão a excluir aqueles que são classificados como não compartilhando uma suposta origem, faço a pergunta sobre os meios que poderiam torná-las mais inclusivas.Palavras-chave: Identidade imanente; identidades contingentes; metamemória; origens; conformação cognitiva grupal; vivo.
Targeted Stimulation of an Orbitofrontal Network Disrupts Decisions Based on Inferred, Not Experienced Outcomes
Authors: Wang Fang , Howard James D. , Voss Joel L. , Schoenbaum Geoffrey , Kahnt Thorsten
Published: October 2020

When direct experience is unavailable, animals and humans can imagine or infer the future to guide decisions. Behavior based on direct experience versus inference may recruit partially distinct brain circuits. In rodents, the orbitofrontal cortex (OFC) contains neural signatures of inferred outcomes, and OFC is necessary for behavior that requires inference but not for responding driven by direct experience. In humans, OFC activity is also correlated with inferred outcomes, but it is unclear whether OFC activity is required for inference-based behavior. To test this, we used noninvasive network-based continuous theta burst stimulation (cTBS) in human subjects (male and female) to target lateral OFC networks in the context of a sensory preconditioning task that was designed to isolate inference-based behavior from responding that can be based on direct experience alone. We show that, relative to sham, cTBS targeting this network impairs reward-related behavior in conditions in which outcome expectations have to be mentally inferred. In contrast, OFC-targeted stimulation does not impair behavior that can be based on previously experienced stimulus–outcome associations. These findings suggest that activity in the targeted OFC network supports decision-making when outcomes have to be mentally simulated, providing converging cross-species evidence for a critical role of OFC in model-based but not model-free control of behavior.

SIGNIFICANCE STATEMENTIt is widely accepted that the orbitofrontal cortex (OFC) is important for decision-making. However, it is less clear how exactly this region contributes to behavior. Here we test the hypothesis that the human OFC is only required for decision-making when future outcomes have to be mentally simulated, but not when direct experience with stimulus–outcome associations is available. We show that targeting OFC network activity in humans using network-based continuous theta burst stimulation selectively impairs behavior that requires inference but does not affect responding that can be based solely on direct experience. These results are in line with previous findings in animals and suggest a critical role for human OFC in model-based but not model-free behavior.
Asymmetrical Attribution of Performance in China
Authors: Chen Jacqueline Chen , Xiang Jun
Published: October 2020

Existing studies of the impact of economic development on political trust in China have two major gaps: they fail to explain how economic development contributes to the hierarchical trust pattern, and they do not pay enough attention to the underlying mechanisms. In light of cultural theory and political control theory, we propose adapting performance theory into a theory of “asymmetrical attribution of performance” to better illuminate the case of China. This adapted theory leads to dual pathway theses: expectation fulfillment and local blaming. Using a multilevel mediation model, we show that expectation fulfillment mainly upholds trust in the central government, whereas local blaming undermines trust in local governments. We also uncover a rural–urban distinction in the dual pathway, revealing that both theses are more salient among rural Chinese.
Reconstructing Zarzuela Performance Practices ca. 1900
Authors: Rodríguez Eva Moreda
Published: October 2020

This article makes an initial contribution to the largely unexplored field of historical performance practice in zarzuela by examining the earliest surviving recordings of Manuel Fernández Caballero’s Gigantes y cabezudos (1898). One of the greatest successes of the género chico subgenre of zarzuela during the early years of commercial phonography in Spain, it is also the zarzuela of which the most recordings made before 1905 have survived: nineteen, made on wax cylinders by local gabinetes fonográficos and on disc by Gramophone. Both the thriving género chico culture and its singing practices, as well as the technological, commercial, and cultural aspects of the early recording industry in Spain, are discussed to consider how recordings related to live performance in this particular context, what the value is of these recordings as documents of performance practice, and what questions they open up for further study of performance practice in zarzuela.
Modernist Music for Children
Authors: Miller David H.
Published: October 2020

On several occasions in the midcentury United States, the music of Anton Webern was reimagined as music for children. In 1936 conductor and musicologist Nicolas Slonimsky published the score of Webern’s op. 10/4 on the children’s page of the Christian Science Monitor. In 1958 Webern’s op. 6/3 was featured in a New York Philharmonic Young People’s Concert, the first conducted by Leonard Bernstein. Eight years later, Webern’s Kinderstück (Children’s Piece) received its posthumous premiere at Lincoln Center, performed by a nine-year-old pianist. In each case children served as a marker of accessibility, meant to render Webern’s music more palatable to adult audiences; thus was Webern’s music subsumed within the middlebrow circulation of classical music. Although recent scholarship has considered the intersections between modernist music and middlebrow culture, Webern’s music has remained absent from these discussions. Indeed, Webern’s terse, abstract, and severe compositions might at first appear ill suited to middlebrow contexts. Yet, as these three historical moments make clear, children served as a potent rhetorical force that could be used to market even this music to a broad audience of adults.
Children, Accountability and Justice: Advancing Restorative Justice for Child Soldiers and Child Pirates
Authors: Salomé Jacqueline
Published: October 2020

The variance in the international community’s approach to justice for child soldiers and child pirates is curious – why is it that child pirates are faced with impunity or, alternatively, harsh criminal sentences, sometimes in adult courts and prisons, while child soldiers are offered restorative justice with a focus on rehabilitation and reintegration? There are many commonalities in the role and experience of child soldiers and child pirates, most notably in terms of their indistinct role as victim and perpetrator. Nonetheless, the international conception of these children and the legal and policy responses to their crimes are vastly different. Restorative justice is widely accepted as an appropriate response to cope with child soldiers in post-conflict settings due to its ability to uphold the accountability of the child, prioritize rehabilitation, healing, and reintegration, and act as a prevention mechanism for re-entry into conflict. It seems the same should apply to child pirates – strangely, it does not.
Child Soldiery in the Information Age
Authors: O'Bright Ben
Published: October 2020

In 2007, Estonia was the victim of a significant, coordinated cyberattack, which crippled government communications, newspaper websites, banks and other connected entities in Europe’s most Internet-saturated country. At the time, leading theories suggested that Russia, or at the very least elements of its intelligence community, might be somehow involved, spurred by the physical symbolism of Estonia removing Soviet-era monuments from city squares and public spaces (Davis, 2007). Indeed, in an attempt to visibly remove its history of engagement as part of the Soviet Union, Estonian authorities and political figures had become determined to demolish and destroy remaining statues erected pre-1990. Two years after the cyberattack, an event that Wired Magazine colloquially termed “Web War One,” further details of the unexpected perpetrators would begin to emerge. According to reports by the Financial Times and Reuters, Nashi, a pro-Kremlin youth group with an estimated membership of 150,000, claimed responsibility for the digital assault against Estonia; they described to authorities a strategy of repeated denial-of-service (DoS) attacks, (Clover, 2009; Lowe, 2009). Nashi members, based on different sources, range between the ages of 17 and 25 (Knight, 2007).
Commentary: Children and Cyberwar: Victimization through Protection?
Authors: Penney Jon
Published: October 2020

Mr. O’Bright has offered an important essay on the many complex issues and questions raised by child soldiers in the information age. With an aim to supplementing his helpful discussion, this brief comment examines state obligations to prevent children from becoming involved in hostilities as I believe it raises challenges unique to cyberwarfare, while also highlighting the importance of Mr. O’Bright’s central question— which international legal norms can be applied to cyberwar, and which require fundamental changes or rethinking.
Preventing Recruitment to Improve Protection of Children
Authors: Whitman Shelly , Baillie Abidi Catherine
Published: October 2020

In order to progressively end the recruitment and use of children as soldiers, the world must focus on effective prevention. The impacts of violence on children affected by armed conflict, and particularly those recruited and used as soldiers, are substantial. Thus, in order to break endemic cycles of violence and achieve peace and security globally, we need to prioritize the prevention of recruitment and the protection of children. This article features examples of effective prevention-oriented strategies, including tangible and practical methods that can be implemented towards the ultimate goal of preventing the recruitment and use of children as soldiers.Keywords: prevention, child soldiers, violence, children and armed conflict, Vancouver Principles
CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITIES OF HOMALOMENA VIETNAMENSIS BOGNER & V. D. NGUYEN (ARACEAE)
Authors: Van Thien Hong , Nguyen Quang Phuc , Tran Gia Buu , Huynh Nguyen Tuong An
Published: October 2020

Homalomena vietnamensis is a rare species of the Homalomena genus and only found in Middle region of Vietnam. In this study, we found 10 compounds in ethanol extracts of leaf and rhizome of H. vietnamensis, such as cadinane-4β,5α,10α-triol, oplopanone, 4-epi-oplopananol, 2α-hydroxy homalomenol A, 1β,4β,7β-Trihydroxyeudesmane, homalomentetraol, 4-acetoxyoplopananol, 5,7-diepi-2a-acetoxyoplopanone, eudesma 4β, 7α- diol-1β-fumarate), and homalomenol F, via liquid chromatography-mass spectrometry (LC/MS). Moreover, the antibacterial activity of ethanol extracts of leaf and rhizome from this species has been evaluated by disc diffusion method for the first time. The results showed that rhizome extract of could inhibit the growth of 5 tested micro-organisms, including of Bacillus cereus (28.3 ± 1.5 mm), Salmonella enteritidis (19.5 ± 1.5 mm), Staphylococcus aureus (16.3 ± 1.5 mm), Escherichia coli (14.7 ± 1.2 mm), and Pseudomonas aeruginosa (8.2 ± 0.8 mm), while the leaf extract showed antibacterial effect against Bacillus cereus (22.0 ± 2.0 mm), S. enteritidis (14.7 ± 0.6 mm), and S. aureus (12.5 ± 1.8 mm).
ANTI-STAPHYLOCOCCAL POTENTIAL OF FUSARIUM SP: FUNGAL ENDOPHYTE ISOLATED FROM RAUWOLFIA SERPENTINA
Authors: Gambhir Lokesh , Kapoor Neha , Saxena Sanjai
Published: October 2020

Fungal endophytes are considered as repository of potent novel bioactive compounds with profuse chemical diversity. These bioactive compounds have been widely utilized in pharmaceutical and agrochemical industries. The present work was undertaken to bio-prospect the fungal endophytes from Rauwolfia serpentina, a medicinal plant used in multiple indigenous preparations, for possible therapeutic interventions. 21 fungal endophytes were isolated from Rauwolfia serpentina with maximum colonization in leaf (42.8 %) followed by bark (33.3%) and stem (23.8%). In the enzymatic activity screening, #15RSBNEY was found to be potent amylase producer and #3RSSTNEY as potential cellulase producer. Further, three isolates viz. #16RSLBRT, #10RSLBRT and #23RSSTNEY exhibited promising antibacterial activity with maximum activity exhibited by #10RSLBRT against all test strains of Staphylococcus aureus. Interestingly, it was observed that antibacterial activity of #10RSLBRT increased by two fold after fractionation with acetone and chloroform. Based on above result, the culture filtrate of #10RSLBRT was extracted with hexane, chloroform and ethyl acetate followed by agar well gel diffusion method for antibacterial activity. The crude ethyl acetate residue of #10RSLBRT hereby exhibited potent antibacterial activity. The potential isolate i.e. #10RSLBRT was identified by molecular taxonomic tools using internal transcribed spacer rDNA analysis and was clustered in the Fusarium incarnatum-equiseti complex. Further studies on the characterization of bioactive compounds of ethyl acetate extract of # 10RSLBRT are warranted for the development of anti-staphylococcal therapy.
Interventionen in die Produktion algorithmischer Öffentlichkeiten.
Authors: Pöchhacker Nikolaus , Burkhardt Marcus , Geipel Andrea , Passoth Jan-Hendrik
Published: October 2020

Die fortschreitende Digitalisierung des gesellschaftlichen Lebens erzeugt neben vielen anderen Phänomenen auch neue Logiken der Informationsvermittlung. So wird seit einiger Zeit die Problematik der Filter Bubble durch Personalisierung von Informationszugängen intensiv diskutiert. Algorithmische Systeme als Vermittler personalisierter Informationen, hier verstanden als Infomediaries (Morris 2015), können zu einer Zersplitterung von Öffentlichkeiten führen – Individuen werden verstärkt mit selektiven Informationen und Diskursen konfrontiert, welche die eigenen Haltungen bestärken und abweichende Meinungen ausblenden. Diese Transformation stellt vor dem Hintergrund der informationellen Grundversorgung gerade für den öffentlich-rechtlichen Rundfunk eine Herausforderung dar. Der vorliegende Beitrag nimmt dies zum Anlass, um die Beziehung und Möglichkeiten der Realisierung des Programmauftrags in Zeiten non-linearer Medienangebote zu diskutieren. Der Artikel ist ein erstes Ergebnis der Zusammenarbeit zwischen den Autoren und der Softwareentwicklungsabteilung des Bayerischen Rundfunks im Rahmen der Entwicklung einer neuen Mediathek. In einer kollaborativen Ethnographie wurden Rahmenbedingungen und Gestaltungsmöglichkeiten algorithmisch vermittelter Programme, welche dem gesellschaftlichen Auftrag der öffentlichrechtlichen Rundfunkanstalten genügen, erforscht. Entgegen der Annahme, Algorithmen seien unhinterfragbare und dadurch mächtige Akteure, zeigt sich, dass die Realisierung algorithmischer Systeme sowohl von sozio-technischen Aushandlungsprozessen als auch von infrastrukturellen und organisatorischen Bedingungen abhängt, und sich somit gerade in den Entwicklungsprozessen inhaltliche und politische Gestaltungsräume von Recommender Systemeneröffnen.
Die 'Bildung des politischen Subjekts' im Netz?
Authors: Maurer Susanne
Published: October 2020

Der Beitrag reflektiert Fragen in Bezug auf die 'Bildung des politischen Subjekts' im Verhältnis zu 'Digitalität'. Dabei geht es um Prozesse 'politischer Bildung', für die nicht nur die Entwicklung und Ausprägung kritischen Urteilsvermögens ausschlaggebend sind, sondern auch die – Bildungsprozesse insgesamt kennzeichnende – Qualität der Selbst-Transformation. Gerade im Hinblick auf diesen Aspekt der Selbst-Transformation werden Dimensionen wie 'Erfahrung', 'Beziehung/Begegnung', 'Leiblichkeit/Körperlichkeit' und 'Präsenz' relevant. Der Beitrag spricht diese Dimensionen deshalb auch mit Bezug auf (kollektives bzw. verknüpftes) politischaktivistisches Handeln an – in der Spannung zwischen digitalen/digitalisierten und analogen Praktiken. Mit Bezug auf ein konkretes Beispiel, die „militanten Streifzüge durch die Kreisläufe der Prekarität“ der Precarias a la deriva, wird schließlich die politische Bedeutung einer auch analogen aktivistischen Praxis herausgestellt.
Eosinophil otitis media – egy kevéssé ismert kórkép kezelési nehézségei
Authors: Révész Péter , Gerlinger Imre , Kálmán Endre , Koukkoullis Alexandros , Burián András , Tóth István
Published: October 2020

Absztrakt:

Az eosinophil otitis media az utóbbi évtizedben került a kutatók és a klinikum
látóterébe; jellemzője a középfülben termelődő, eosinophil granulocytákkal
telített mucosus, nehezen eltávolítható váladék és az asthma bronchiale,
valamint a krónikus rhinosinusitis társulása. A betegség egyelőre kevéssé ismert
a klinikumban, emiatt nincsenek információk a pontos előfordulási gyakoriságáról
sem. A kórkép nem gyógyítható, de kezelésére beváltak az intratympanalisan
használható szteroidkészítmények, melyek azonban csak enyhébb fokú betegség
esetén vezetnek eredményre. A súlyosabb gradusú eosinophil otitis media dobüregi
granulációs szövet képződésével és idegi halláscsökkenéssel is járhat, ami
sebészi eltávolítást és per os szteroidkezelést is igényel.
Fontos felhívni a figyelmet a kórkép létezésére, mert a megfelelő diagnózis
felállítása után az időben elkezdett kezeléssel elkerülhető lehet az
életminőséget rontó fülváladékozás, felülfertőződés és az idegi halláscsökkenés.
A jelen közleményben a szerzők a nemzetközi szakirodalom áttekintésén túl saját
esetbemutatásokon keresztül demonstrálják a betegség enyhe és súlyos fokú
változatának kezelési lépéseit. Orv Hetil. 2020; 161(41): 1769–1775.
Stigma and Abortion in Argentina
Authors: Drovetta Raquel Irene
Published: October 2020

This paper examines the stigma of abortion among professionals who are providers of the service, considering, in particular, the time when they joined the Network of Healthcare Professionals for the Right to Decide. This network was created in Argentina at the end of 2014 by a joint alliance of women’s and feminist organizations and healthcare professionals. We have conducted an exploratory study, of a descriptive type, based on a qualitative strategy. From 2016 to 2018, we carried out interviews with healthcare professional, with a view to addressing the relationship between the stigma of abortion and the healthcare professionals who are members of the Network. The main results indicate that the professionals have changed their perception of the stigma of abortion by becoming members of a group made up of peers among whom there exists homogeneity regarding their goals, and objectives in their profession. They admit to gaining confidence to resist stigma indicators, such as a negative self-perception of the job done, the fear of information disclosure and the silencing of, and detachment from fellow professionals. The experience permits to show how it is possible to resist stigmatization effects, by performing an active role regarding professional identity.
EARLY PREDICTORS OF HOSPITAL MORTALITY IN PATIENTS WITH COVID-19 PNEUMONIA AT A LEVEL III HOSPITAL. LIMA, PERU.
Authors: Ravelo-Hernández Jorge , Cáceres-Bernaola Ursula , Becerra-Nuñez Claudia , Mendívil-Tuchia Sabina , Vásquez-Rivas María Eugenia , Aguirre-Quispe Wilfor , Quispe-Ayuque Edwin , Reyes-Rocha Gabriela
Published: October 2020

Objective: Determine whether the tomographic characteristics of patients with COVID-19 pneumonia at hospital admission and the initial tomographic severity score (TSS) as well as some laboratory tests or clinical characteristics predict mortality and length of hospital stay.Material and methods: Analytical, retrospective study that included 203 patients with a clinical diagnosis of SARSCoV2 Virus Infection, performed by reverse transcriptase polymerase chain reaction (RT-PCR), reactive serological test (IgM/IgG) and/or spiral computed tomography (CT) chest without contrast, admitted in the period from 6 April to 27 June 2020. Two radiologists (blind evaluators) described the tomographic findings. 15 patients with normal CT were excluded, 188 patients with clinical and laboratory parameters were admitted to the statistical analysis of TSS and mortality; data taken from epidemiological records and clinical histories, divided into two groups: recovered and deceased. Data analysis used the statistical package Stata version 14.2; hospital stay was analyzed by Kaplan – Meier curves and mortality prediction was made by Cox regression with 95% CI and a p value <0.05 as statistically significant.Results: Hypertension was the most frequent associated disease, the most common clinical presentation included cough, malaise, fever and dyspnea , there were no significant differences between studied groups   (Recovered  vs. death patients), 15 cases had normal CT, for this reason, they were excluded from the TSS score and mortality analysis. Mean age of the recovered patients was 53.6 ± 16.4 years and of the deceased 75.9 ± 13.9 years (p <0.0001). A moderate and high TSS (≥ 8) resulted in deaths (p <0.05), as well as a higher degree of lymphopenia and a history of asthma in the deceased (p <0.05). The variable arterial hypertension predicts the increase in days of hospital stay (p <0.05). The ground glass pattern was the most frequent, followed by the consolidation and distortion of the architecture; however, they were not associated with a type of outcome. The pattern of pleural effusion and bronchial dilation showed a significant difference with respect to the outcome, however, but it could be due to the infrequency of presentation of these patterns. Conclusions: TSS is useful in the initial and comprehensive diagnostic evaluation of COVID-19 pneumonia, in conjunction with markers such as lymphopenia and elevated CRP that can predict a poor short-term outcome. A high TSS score is a predictor of mortality. Hypertension predicts the increase in days of hospital stay.
A literature review on delayed ettringite formation: mechanism, affect factors and suppressing methods
Authors: Zhang Yulu , Pan Yifan , Zhang Dakang
Published: October 2020

The expansion deterioration that occurs in concrete structures exposed to high temperature fluctuation in wet environments is often attributed to delayed ettringite formation (DEF). Due to the complex mechanism and various factors that influence DEF, it is difficult to establish effective methods for predicting the expansion and suppressing deterioration. With the aim of improving the durability and long-term maintenance of concrete structures at risk of DEF expansion, this review paper summarises the required conditions and factors influencing DEF and provides a detailed description of the DEF mechanism. Previously proposed methods for suppressing DEF expansion are summarised in detail and their practical applicability is discussed. Furthermore, a review of literature regarding methods for predicting expansion development is provided, considering prevention of DEF expansion. This work clearly highlights the current status of DEF research, and the data summarised in this paper are expected to be a valuable reference for investigating control or suppression of DEF expansion.
Effect of Irrigation Waters in Different Salinity Levels on Crop Yield and Energy Use in Greenhouse Tomato Production in Turkey: A Case Study in Kırklareli Province
Authors: ÇEBİ Ulviye , AYDIN Başak , ÖZER Selçuk , ÖZTÜRK Ozan
Published: October 2020

This study was carried out in a quonset type plastic covered unheated greenhouse on the lands of Atatürk Soil Water and Agricultural Meteorology Institute in Kırklareli, Turkey. In the study, the effect of different salinity and irrigation water levels which were applied to tomato plant, irrigated by drip irrigation in greenhouse, on yield and energy use efficiency was evaluated and the optimum irrigation application was determined. In the study, ‘Swanson F1’ type tomato was grown as plant material. The trial was carried out on 36 parcels with three repetitions according to split plots trial design and four different irrigation water salinity levels were on main plots and three irrigation levels were on sub plots. The best result was obtained from T1S2 subject in terms of yield and energy use efficiency. The average yield was determined as 109060 kg ha-1 and energy output/input ratio, energy productivity and specific energy were found as 1.51, 1.89 kg MJ-1 and 0.53 MJ kg-1 in T1S2 subject, respectively. It was concluded that the optimum method should be on low salinity level and the irrigation water application should be on the level in order to bring the current moisture level to the field capacity.
TRANSIENT ANALYSIS OF SIMULTANEOUS LOFA AND RIA IN RSG-GAS REACTOR AFTER 32 YEARS OPERATION
Authors: Isnaini Muhammad Darwis , Kuntoro Iman , Subekti Muhammad
Published: October 2020

During the operation of the research reactor RSG-GAS, there are many design parameters should be verified based on postulated accidents. Several design basis accidents (DBA) such as loss of flow accident (LOFA) and reactivity-initiated accident (RIA) also have been conducted separately. This paper discusses about possibility of simultaneous accidents of LOFA and RIA. The accident analyses carry out calculation for transient condition during RIA, LOFA, and postulated accident of simultaneous LOFA-RIA. This study aims to conduct a safety analysis on simultaneous LOFA and RIA, and investigate the impact on safety margins. The calculations are conducted by using the PARET code. The maximum temperature of the center fuel meat at nominal power of 30 MW and steady state conditions is 126.10°C and MDNBR of 2.94. At transients condition, the maximum center fuel meat temperature for LOFA, RIA and simultaneous LOFA-RIA are consecutively 132.99°C, 135.67°C and 138.21°C, and the time of reactor trip are 3.2593s, 3.6494s and 2.7118s, respectively. While the MDNBR for LOFA, RIA and simultaneous LOFA-RIA are respectively at transient condition are 2.88, 2.58 and 2.63, respectively. It is shown that, simultaneous LOFA-RIA has the fastest trip time. In this case, the low flow trip occurs first in advance to over power trip.  From these results, it can be concluded that the RSG-GAS has adequate safety margin against transient of simultaneous LOFA-RIA.Keywords: RSG-GAS, Simultaneous, LOFA, RIA, PARET
SAFETY ANALYSIS OF NEUTRON INTERACTION WITH MATERIAL PRACTICUM MODULE FOR THE KARTINI INTERNET REACTOR LABORATORY
Authors: Sadewo Prasetyo Haryo , Wahyono Puradwi Ismu
Published: October 2020

Kartini Research Reactor, which is situated in Yogyakarta, is a 100 kW TRIGA (Training, Research, and Isotope Production by General Atomic)-type reactor mainly used for educational and training purposes. A system for remote learning on nuclear reactor physics named the Internet Rector Laboratory has been developed and is fully operational since 2019. To enrich its curriculum, a new practicum module has been developed, that can be immediately implemented and does not require any additional equipment or materials. To ensure safety in reactor kinetics and radiation protection, a safety analysis on the implementation of the practicum module has been conducted using MCNP and ORIGEN utilizing the current conditions of the reactor regarding its fuel burnup and control rod positions at a certain power level. Based on the results of the analysis, the practicum is safe to perform from a neutronic and radiation protection perspective. Given the long half-life and the large amount of radiation exposure that comes from activation products of iron, it is recommended that only cadmium, boron, graphite, and aluminum are allowed to be irradiated during the practicum.Keywords: Internet Reactor Laboratory, Activation Product, Radiation Protection, Reactor Safety
Synthesis of 4-(1-Adamantyl)-1-Naphthol and 4-(1-Adamantyl)-1-Methoxynaphthalene
Authors: Kondrasenko Alexander A. , Peterson Ivan V. , Rubaylo Anatoly I.
Published: October 2020

Adamantylation of 1-napthol and 1-methoxynaphthol in the mixture of phosphoric and glacial acetic acids leads to the formation of 2- and 4-substituted products. Formed products are less involved into the further oxidative transformations in used conditions
Mercarbide Catalyst for Alcohol Ethoxylation
Authors: Butenko Ella O. , Kapustin Alexey E.
Published: October 2020

Mercarbide catalyst was studied for the ethoxylation of methanol and 1-heptanol. Mercarbide catalyst is very active for the narrow-range ethoxylation of 1-heptanol. The narrow distribution of ethoxylation units in the ethoxylates is elucidated by the constrained reaction on the mercarbide catalyst. In the proposed surface reaction scheme, the following points are presented. The relatively basic reactants, ethylene oxide and alcohols or ethoxylates, are adsorbed on the relatively acidic sites of the surface. There is a decrease of ethoxylation rate in each additional ethylene oxide insertion step, due to a smaller number of the ethylene oxide molecules adsorbed near the growing point of alcohol ethoxylates. The difference in ethylene oxide insertion rates with the numbers of oxyethylene units in the ethoxylate products causes peaking of the distribution
Mjerenje protoka plina na platformi Ivana A
Authors:   Epik d.o.o., Orešković Bruno
Published: October 2020

Danas se na offshore plinskim postrojenjima koristi nekoliko metoda za mjerenje protoka: mjerenje protoka dP (metodom pada tlaka), mjerenje protoka ultrazvukom, mjerenje protoka masenim protokomjerom, mjerenje protoka na temelju fizikalne pojave vrtloga (vortex) i mjerenje protoka termalnim efektom. Cilj ovog članka je obraditi metodu mjerenja protoka metodom pada tlaka (dP) koja se koristi trenutno na Ininoj platformi Ivana A te prikazati ispitna izvješća s platforme. U članku se razmatraju strojarske komponente koje je potrebno ugraditi, instrumente koji se upotrebljavaju prilikom mjerenja, kao i kroz upravljačke sustave (DCS ili SCADA) na kojima se obrađuju izmjerene vrijednosti te prikazuje jedinični protok plina.
Magnitude Calculation without Saturation from Strong-Motion Waveforms
Authors: Hongcai Zhang , Melgar Diego , Goldberg Dara E.
Published: October 2020

After destructive earthquakes, it is a challenge to estimate magnitude rapidly and accurately for dissemination to emergency responders and the public. Here, we propose criteria to calculate peak ground displacement (PGD) from strong-motion records, which can be used to calculate unsaturated event magnitude. Using collocated strong-motion and Global Navigation Satellite Systems observations of five major earthquakes in Japan, we demonstrate the effectiveness and accuracy of our strategy. Our results show that, with the right filtering criteria, PGD estimated from strong-motion acceleration waveforms is consistent with geodetic estimates. The methodology, however, does not allow for calculation of reliable estimates of coseismic deformation or other ground displacement metrics. We demonstrate a simulated real-time magnitude estimation that suggests it is feasible to generate an unsaturated magnitude estimate in real time from near-field strong-motion records. These findings have important implications for early warning and emergency response in seismically active areas, especially where real-time strong-motion data are more widely available than geodetic measurements.
Snoring and dental treatment
Authors: Ali Hassan Shaik , Bhateja Sumit , Arora Geetika , Prathyusha Francis
Published: October 2020

Resting is a significant physiological function in everyday life. A decent giggle and a long rest are the best fixes in the specialist's book. Rest issues of the upper aviation route result from any condition or sickness that causes its fractional or complete obstacle when a patient expects a recumbent position and rests. Rest issues, especially untreated obstructive rest apnoea (OSA) can be related to engine vehicle mishaps, helpless work execution in the workplace, or work environment, and makes an individual inclined to word related mishaps and diminished personal satisfaction. Exhaustive administration of upper aviation route rest issues requires an interdisciplinary methodology. In this article, we will use various approaches to snoring.
In-silico design of epitopes against SARS-CoV-2 based on membrane protein
Authors: Emerson De Lima Procopio Rudi
Published: October 2020

The selection of epitopes has become easier and faster with the aid of bioinformatics. SARS-CoV-2 is a single-stranded positive RNA virus (+ ssRNA) with approximately 30 kilobases, containing four main structural proteins: spike glycoprotein (S); small envelope protein (E); membrane protein (M); and nucleocapsid protein (N), which can generate epitopes. The protein chosen in this study was membrane glycoprotein ORF5, with 669 nt forming 222 amino acids. The analysis of the interaction of the protein with the membrane showed that most of the protein is inside the viral envelope and approximately 25 amino acids outside, where the initial and final regions of the protein are ideal for generating epitopes. The first 20 amino acids (MADSNGTITVEELKKLLEQW) were chosen because they are on the outer surface of the membrane of the viral envelope. For the production of heterologous protein in , two expression systems (pET-28a and pFLAG-ATS) were used to carry out the various immunological tests necessary to validate the results obtained.
Effects of Gilsonite on Performance Properties of Bitumen
Authors: AHMEDZADE Perviz , ALQUDAH Omar , GÜNAY Taylan , GEÇKİL Tacettin
Published: October 2020

The effectiveness of natural Gilsonite on the performance properties of modified bitumens was studied. Three samples having different ratios of Gilsonite that are 6%, 8% and 10% by weight of base bitumen which was PG 64-16 grade were prepared. The physical properties and storage stabilities of four samples were investigated by means of conventional tests. The short-term and long-term aging processes of bitumens were conducted with rolling thin oven and pressure aging vessel tests, respectively. Rheological properties of bitumens were examined by means of Superpave tests such as rotational viscosity, dynamic shear rheometer and bending beam rheometer. After the rheological study, the low and high temperature performance classes of bitumens were determined by the Superpave specification. The results showed that natural Gilsonite-modified bitumens provide improvement in rheological and physical properties of bitumen, and were found highly compatible with base bitumen. Gilsonite additive significantly increased stiffness and viscosity of bitumen, and improved the resistance against fatigue cracking and rutting of bitumen, without causing a reduction in thermal cracking resistance of bitumen.
Socio-economic impacts of migration on Tho Chu island commune, Vietnam
Authors: Le Huong , Phi Hoang , Dao Luu , Nguyen Yen , Le Lien , Nguyen Huu , Le Phuong
Published: October 2020

Population arrangement to islands for settlement is one of the important policies in many ways of each nation. This study was conducted to provide an understanding of the current situation and impacts of the migration to Tho Chu Island, Phu Quoc District, Kien Giang Province, Vietnam. In-depth interviews and survey questions were used to collect preliminary data on displaced people, insular living conditions, positive and negative impacts of the migration process on the socio-economic development on the island. They are also supplemented by secondary data which were collected from various sources in research process. The study shows that the migration to the island not only helps to supplement the labor force for the island, contributes to economic and labor structure restructuring on the island but also contributes to diversifying island economic activities and expand the space, enrich the cultural life of the island. However, the process of migration to the island also poses a number of problems for the people and the government on the island.
MEDIDAS MODERNIZADORAS NO RECIFE DO SÉCULO XIX: ordenamento, progresso e civilidade
Authors: DUARTE JOSÉ LINS
Published: October 2020

O presente artigo objetiva analisar os desdobramentos do Recife no século XIX, mediante a necessidade de implementar melhorias urbanas que envolvessem os aparatos das tecnologias em curso e as medidas de higienização, a fim de atender às carências de uma urbe que se encontrava tencionada pelo adensamento populacional. Além disso, visa avaliar determinadas observações emitidas por estrangeiros e citadinos, quanto às impressões do espaço urbano e à interação com a população. Igualmente, considerar aspectos que levaram, em certo momento, haver maior aproximação entre parcela da sociedade e governo, motivados pela ideia de progresso.
Palavras-chave: Urbe.  Espaço Urbano. Progresso. Higienização.
O COTIDIANO DO HOSPITAL DE CARIDADE DE SÃO LUÍS E A CRISE DA ASSISTÊNCIA NA SEGUNDA METADE DO SÉCULO XIX
Authors: COE AGOSTINHO JÚNIOR HOLANDA
Published: October 2020

A Irmandade da Misericórdia foi fundada em São Luís por volta de 1623. Em 1642, a Irmandade já havia construído uma igreja e um cemitério e, em 1653, já haviam projetos para a construção de um hospital. No século XIX administrava um cemitério, o Hospital de Caridade e dos Lázaros, além da Roda e Casa dos Expostos. Diante de tal crescimento do poderio e importância da assistência praticada pelos congregados na Irmandade da Misericórdia, analisaremos como o tratamento dispensado aos doentes no Hospital de Caridade foi se tornando cada vez mais um “grande fardo” para a Misericórdia, já que, na segunda metade do século XIX, as reclamações eram recorrentes acerca da dificuldade do cuidado para com os enfermos em virtude do acirramento de crises financeiras.  Como o século XIX, em São Luís, foi marcado pelas diversas epidemias que assolavam os aglomerados urbanos, também estudaremos a assistência no contexto dos surtos epidêmicos e as transformações que tais epidemias proporcionaram ao Hospital de Caridade.
Palavras-chave: Hospital. Caridade. Assistência. Crise.
Clústeres regionales como estrategia para superar desventajas competitivas
Authors: Pineda-Ospina Diana Lorena , Rodríguez-Guevara Edgar Guillermo , García-Bonilla Diego Alonso
Published: October 2020

El artículo tiene el objetivo de identificar cuáles son las ventajas de los clúster regionales para incentivar la competitividad de las empresas. Metodológicamente, se aborda un enfoque cualitativo a través de un ejercicio bibliométrico, que permitió la: recopilación, revisión y análisis de documentos publicados entre 2002 y 2019, en las bases de datos Scopus e ISI Web of Science. A partir de una muestra de 170 documentos, se realizó el análisis de contenido para identificar los principales ejes analíticos, que responden al propósito planteado. Entre los resultados se destacan: los avances en la conceptualización de los clústeres; la identificación del clúster como un tipo de aglomeración que facilita la difusión de conocimiento y de transferencia tecnológica entre empresas; y la capacidad del clúster como articulador de instituciones regionales. Los resultados permiten concluir la relevancia de la configuración de los clústeres para el desarrollo productivo regional, y el fortalecimiento de las ventajas competitivas de las organizaciones que lo conforman.
Análisis del comportamiento del turismo informal en la ciudad de Cartagena de Indias, Colombia
Authors: Morelos-Gómez José , Cardona-Arbeláez Diego , Lora-Guzmán Harold
Published: October 2020

En este documento, se analizan el comportamiento de la oferta, demanda y preferencias del turismo de jóvenes mochileros que visitan la ciudad de Cartagena de Indias, Colombia. La investigación es cuantitativa, con alcance descriptivo y de tipo transversal, donde se encuestaron 196 visitantes que utilizaron los servicios turísticos informales de bajo costo, durante 2018. Se encontró que la mayoría de turistas informales, son jóvenes entre 18 y 30 años (68%), profesionales, que buscan una experiencia diferente, de bajo costo, con preferencia para viajar en grupo de amigos, gastar poco dinero y hospedarse en sitios económicos. En el 95% de los casos, eligen sitios que les ofrecen servicio de desayuno y conexión a internet, considerado prioritario, y prefieren alojarse en sitios ubicados principalmente en el centro histórico de la ciudad, por su ambiente bohemio y multicultural. Se destaca que el 67% de los encuestados, posee un nivel de formación universitario. Se concluye con la necesidad de que los operadores turísticos complementen los servicios que ofertan, de modo que satisfagan las expectativas de los turistas mochileros que visitan Cartagena de Indias.