bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Ways of Targeting Triple Negative Breast Cancer (TNBC) with the Latest Research - will it Improve Prognoses
Authors: Kochar Kaur Kulvinder
Published: September 2022

Breast Cancer, is the commonest malignancy that gets diagnosed in women, leading to the greatest cancer associated deaths all over the world. Triple negative breast cancer (TNBC) refers to the absence of estrogen, progesterone and HER2 receptors, possesses an aggressive clinical nature, having the high metastases rat es . Thus here in this review we have tried to study the mechanism responsible for the high metastases rates by studying the role of Haematopoietic protein tyrosine phosphatases (HePTP) which had a crucial role in metastases of TNBC through activation of Wn t/β - catenin signaling. Further we examined, how certain regional anesthetics like ropivacaine and levobupivacaine had a protective effect in BC, roles of some novel therapies like those combining embelin (EMB)/TRAIL - HA(hyaluronic acid)/ poly(1,6 - hexanediol ) - diacrylate – β - 5 - hydroxyamylamine(PBAE) - polyethylamine (PEI) as cytotoxix and proapoptotic agents against TNBC, how regulation of miR 122 - 5p that causes aggression via epithelial mesenchymal transition(EMT) in TIMC via suppression of charged multivesicul ar body protein 3(CHMP3)through MAPK signaling might help in controlling TNBC. Further combining thiosemicarbazone compound 4 with cisplatin increased p53 phosphorylation, along with Bax level induction, as well as a decreased Bcl2 protein amounts ,increas ed PARP cleavage and modulated miR expression levels in TNBCs with special overexpression of miR - 125a - 5p ,and miR - 181a - 5p and thus role of miR control utilization by other way by thiosemicarbazone compound 4 targeting TNBC apoptosis might be utilized. More over how combining Src inhibitor dasatinib, with the PARP inhibitor veliparib, and the DNA damaging drug carboplatin in TNBC might prove effective in TNBC. Further role of DDB2 in causing resistance to PARP, combination of PARP with metabolic inhibitors is discussed. Additionally liposomes modified by fructose and RGD had >potential for forming a targeted TNBC therapy, particularly the covalently modified Fru - RGD – Lip, marking them as good liposomes having multiple functions. Thus novel therapies for TNBC wh ich might help in developing novel therapies further for controlling TNBC has been emphasized.
Successful IVF Pregnancy with the Help of PRP in Woman with Systemic Lupus Erythematosus
Authors: P Kumari
Published: September 2022

Patients with systemic lupus erythematosus suffer from varying degree of subfertility & some of them have infertility. It is associated with obvious maternal and fetal complications including spontaneous abortion in first trimester. We report a case with IVF pregnancy who conceived successfully in a patient with systemic lupus erythematosus. A 32 years old nulliparous woman suffering from infertility since 7 years diagnosed with SLE 5 years back presented for IVF. She underwent frozen- thawed embryo transfer after antagonist cycle of ovum pick & received autologous PRP intrauterine instillation. The patient responded well & conceived in 1st attempt of IVF. Now she has continued her pregnancy up to 6 weeks of GA without any complications. This case report indicates that the PRP can be an emerging option for improving endometrial receptivity and good outcome in IVF patients in coming years.
Gas-Phase Isotopic Immunometry based on Reflectron-Assisted in Situ Detection of Products of Gas Chromatographic Separation of Antibodies and Antigens
Authors: SK Pankratov
Published: September 2022

The system for gas-phase immunometric measurements with isotopic resolution is proposed. This system based on the reflectron-based Finnigan MAT mass spectrometer can be used in combination with gas chromatograph or gasliquid chromatographic device. The IMMUNOREFLECTRON-2016 project has been quickly closed for the organizational \ administrative reasons, and all the schemes are now confined in the room where this project has been started. Consequently, it is only possible to propose the variants of similar research and development task solutions in different conditions.
Certain Inflammatory Changes in Scabies Stressed Patients Treated with Permethrin 5%
Authors: MM Majid
Published: September 2022

The main manifestations of scabies disease are mediated through inflammatory and hypersensitivity like-reactions to mite products that lead to itching with different lesions. The initial inflammatory response is towards the mite and its products. The aim of this study is to Determinate certain inflammatory elements including eosinophil, CRP and ESR in Scabies patients (ordinary and Prisoners) treated with Permethrin 5%. The study included (28) Ordinary, (32) prisoners scabies patients as well as (30) healthy person as a control group. Determination of CRP was done by Ichroma, ESR by using (Mix RAT 20, VITAL) and Eosinophil count determined from complete blood count (CBC). The results showed that the level of CRP in sera of ordinary scabies patients was somewhat higher (non- significantly) as compared to prisoners (3.60±0.44 vs.2.75±0.35 mg/L), in pre-treatment stage, while in post-treatment, the levels were elevated in prisoners (non- significantly) as compared to ordinary scabies patients (3.57± 0.59 vs. 3.29±0.31mg/L) respectively. ESR levels were significantly increased in both patient groups (ordinary 25.68±2.97 and prisoners 25.34±0.77 mm/hr ) in comparison to control (8.0±1.06 mm/hr), but significantly decreased values (9.46±0.17 mm/hr) were recorded post-treatment in ordinary patients compared to that (19.78±0.17 mm/ hr) in prisoners. Eosinophil count in (ordinary and prisoners) groups of patients pre-treatment was significantly higher compared to control group (5.9±0.77, 5.2±0.5 and 2.2±0.17 cell/ µl ) respectively., while a decreased mean values of ( 2.4 ±0.17 cell/ µl, 1.7 ±0.17cell/ µl ) were recorded in ordinary and prisoners patients post-treatment.
Development of Techniques about Production of Recombinant vaccines and cells with Activated Immunogenic potential
Authors: IV Sainova
Published: September 2022

Methods about derivation of myeloid-like and lymphoid-like cells from normal embryonic fibroblasts were developed and tested. Balb/c mice normal mouse embryonic cells from line 3T3 were co-cultivated with mouse malignant myeloma cells, containing inserted. Murine Leukemia Virus (MuLV) (with RNA-genome, Retroviridae family). For this goal, separate subpopulation of normal mouse embryonic fibroblasts were pre-incubated in cultural fluid, supplemented by previous incubation of myeloma cells in it, after subsequent centrifugation and filtration. Other sub-populations of 3T3 cells were co-cultivated with myeloma cells, by addition of cultural fluids plus cellular suspensions of both types. Subsequently, all mixed cultures were freezed after addition of cryo-protector Dimethylsufoxide (DMSO), subsequently thawed and re-incubated in standard laboratory conditions. In the cultures, pre-incubated in cultural fluid, supplemented by previous incubation of mouse malignant myeloma cells, cells in different stages of myeloid/phagocyte and lymphoid/plasmatic cell differentiation were observed, but in addition of suspensions of cells from both types, appearance of hybrid cells of myeloid-like and phagocyte-like, as well as of lymphoid-like and plasmatic cells-like with mouse malignant myeloma cells were noted. The established changes could be explained with the eventual existence of capable to differentiate to various lineages stem-like cellular sub-populations in the general 3T3 cell line. Also, activated fusion between different cells, as well as between cells and viral particles on the influence of DMSO and of the drastic temperature changes was proposed, which could also lead to transfer of nucleotide sequences. On this principle, a possibility for production of recombinant viral vaccines by exchange of nucleotide sequences between cells and viral particles could be suggested. Furthermore, in confirmation of the literature findings, a capability of non-myeloid and non-lymphoid cells to produce membrane receptor glycoproteins was proposed.
A Holistic Review on Chloroquine/Hydroxychloroquine the AntiParasitic Therapeutics
Authors: A Abdelmoktader
Published: September 2022

Hydroxychloroquine and chloroquine have driven attention as potential anti-parasitic therapeutics with extended influences against other various medical conditions. Recently, these drugs were presented against the pandemic of COVID-19. In addition, there is a growing data concerning the resistance to the traditional anti-parasitic regimens. Here, we introduce a general descriptive review to demonstrate (1) a rapid historical view for these drugs, (2) their pharmacokinetics, (3) mode of action and how this affected malaria and whether it can applied in other parasitic diseases or not, and (4) their medical manipulations in other medical conditions involving COVID-19 in the top of the list. The review also tried to introduce their limitations of usage in accordance to previous in vitro and clinical settings. We call for further development in their formula for less toxic and more effective pharmaceutical versions.
Covid-19 Pandemic and Its Novel Virus: Lessons Learnt so Far
Authors: Anusiem Chikere Atulaegwu
Published: September 2022

When an epidemic broke out in Wuhan, a Chinese city, late 2019 it resulted in horrifying high morbidity and mortality in the city and subsequently began spreading like wild fire.
Could SARS-Cov-2 Establish Persistent Infection in a Certain Population of Infected Individuals
Authors: K Ikuta
Published: September 2022

Novel coronavirus (SARS-CoV-2) is the causative agent for a new type of pneumonia (COVID-19) that firstly appeared in Wuhan, China, in December, 2019. The virus spread globally throughout the world within just three months next to its eruption, according to the Center for System Science and Engineering (CSSE), Johns Hopkins University, with nearly 2 million infected as of April 14, 2020, and nearly 120,000 deaths.
Pianura Padana Geomorphology, Climate Condition and Diffusion of COVID -19 Hypotesys of Work
Authors: M Luisetto
Published: September 2022

In recent study was verified the statistical hypothesis of diffusion of COVID 19 related some relevant high way of itlay (especially north regions). The geomorphological characteristic of PIANURA PADANA, whit at north closed be ALPI mountain and in south by APPENIMI MOUNTAINS have created since ancient time particular climate condition. If we observe diffusion of Covid 19 in italy at today date is possible to verify a sort of different velocity in diffusion between north region vs the other. There are relationship between this “closed environment “and diffusion of some relevant virus? Pianura padana is famous for its kind of climate with lots of fog, but also for air pollution as reported by EPHA and other organization.
Could UPR Manipulation Help to Tune the Inflammatory Response in the Course of COVID-19?
Authors: M Cirone
Published: September 2022

Highly pathogenic coronavirus SARS-CoV2, belonging to coronaviridae family, preferentially infects alveolar epithelial cells and immune cells resident or recruited in the lung, causing the disease known as COVID-19. As for other viruses, SARS-CoV2 is sensed by several PRRs, particularly TLR3 that triggers an intracellular signaling culminating in activation of transcription factors that promote the release of inflammatory and anti-viral cytokines, deeply shaping immune response. In a subgroup of patents, a massive release of inflammatory cytokines may also occur, strongly contributing to destroy alveolar cells, fibrosis and endothelial injury, thus favoring the activation of coagulation cascade. Viral infection also triggers UPR, an integrated response to stress, by activating the antiviral kinase PKR and by perturbing ER homeostasis. ER stress/UPR strongly contributes to the regulation of cytokine release also because its signaling intersects with PRR signaling at multiple levels. In this perspective we will discuss the possibility to tune the inflammatory/immune response to SARS-CoV2 infection by reducing ER stress, manipulating the different arms of UPR or inducing autophagy.
Evaluation of the Immunomodulatory Activity of the MethanolMethylene Chloride Extract of Parkia Biglobosa Jacq Benth. (Fabaceae) Stem Bark in Mice
Authors: AM Onwuka
Published: September 2022

The study was carried out to assess the effect of methanol/methylene chloride extract (MME) of Parkia biglobosa stem bark on specific and non-specific immune responses in rodents. Adult Swiss albino mice (20-35 g) of either sex were divided into five groups (n=5) and treated for 10 days. The effect of MME on adaptive immunity was evaluated using neutrophil adhesion test and cyclophosphamide-induced neutropenia while mice lethality test was used to evaluate its effect on non-specific immunity. Results of the neutrophil adhesion test showed a significant (P<0.05) increase in neutrophil adhesion at 250 mg/kg. However, there was decrease in neutrophil adhesion at 500mg/kg and 750 mg/kg respectively. The extract also gave no significant protection from cyclophosphamide-induced immunosuppression. Phytochemical analysis revealed the presence of alkaloids, glycosides, saponins, terpenoids, flavonoids and tannins. The oral LD50 of the extract was greater than 5000 mg/kg and considered to be relatively safe. The findings above show that the stem barks extract of the plant enhanced some aspects of specific immunity and therefore to some extent, hold promise for use as an immunostimulatory agent though it may not offer good protection from the effect of cyclophosphamide on the haematopoietic system.
Nanotechnology: An Aid to Human Welfare in COVID-19 Pandemic Era
Authors: M Tripathi
Published: September 2022

The novel coronavirus disease 2019 (COVID-19) outbreak has led to a worldwide demand for efficacious identification and medication as well as preventing the spread of infection. Based on an abundance of engineered materials recognizable through their useful physicochemical properties, nanotechnology provides a number of perspectives to tackle with this pandemic disease. Nanotechnology can aid to fight against COVID-19, infectious diseases in general, as well as future pandemics. It works on nano scale level ranging from 0 to 100 nanometers. Nanoparticles are small in size but they have greater surface area in comparison to large sized molecules which increase its efficiency. The technology has potential to manipulate the molecules in our desired nature. Nanoparticles are used in almost every area for human welfare. It can be also be a useful tool for the treatment of COVID-19 outbreak like development of rapid detection kits for the testing of COVID-19 infection. Nano biotechnology may also be helpful to cure many other chronic diseases, in development of improved personal protective equipment including facemasks, effective vaccines and targeted drug delivery systems. Summarily, nanotechnology can be crucial in preventing COVID-19 and future pandemics.
Sperm Cell Damage Induced by Urogenital Tract Infections
Authors: V Kumar
Published: September 2022

Male infertility has traditionally been diagnosed by microscopic assessment of concentration, motility and morphology of sperm in the ejaculate. These tests are essential to provide the fundamental information on sperm quality. However, evidence based medicine shows that sperm DNA fragmentation (SDF) tests can also differentiate fertile from infertile males.
In Silico Study by Quantum MicroRNA Language for the Development of Anti-COVID-19 Agents: COVID-19 Is Prevented by Rice MIR2097-5p through Suppression of SARS-Cov-2 Viral MicroRNAs plus HIPK2 Target Proteins
Authors: YR Fujii
Published: September 2022

Objective: The pandemic of coronavirus disease 2019 (COVID-19) is caused by severe respiratory syndrome human coronavirus 2 (SARS-CoV-2). We have previously found that mutations in haplotype C79F upon MAVS/VISA in CaucasianAmerican and African-American were fatal to COVID-19 compared to Asian-American in the USA model (approximate 100 times to Asian), which showed that there is a risk factor of people in Europa/America. This result was simulated by the integrated network algorithm as the MicroRNA (miRNA) entangling sorter (METS) analysis with quantum miRNA language. Since SARS-CoV-2 replication has been blocked in vitro and in patients by Honeysuckle, traditional Chinese herbal medicine, MIR2911, it was further investigated in silico that Japanese people might have some advantages into their culture against COVID-19 for prevention of SARS-CoV-2. Materials and Methods: The METS computer analysis was performed as previously described. Information about coronavirus and miRNAs was extracted from the Viral Genomes and miRBase databases, respectively. The binding affinity between SARSCoV-2 miRNAs and their targets was computed by mfold analysis. Sequence homology analysis among honeysuckle MIR2911 and other miRNAs was performed by BLASTN database. Results and Discussion: The sequences of rice osa-MIR2097-5p was 52% homologous to those of MIR2911 and both plant miRNAs had similar properties in the quantum miRNA language. MIR2097-5p showed binding activity to SARS-CoV-2 viral miRNAs derived from the orf10 region and the 3’ untranslated region (3’UTR) of the SARS-CoV-2 genome. Since MIR2097-5p simultaneously inhibited human homeodomain-interacting protein kinase 2 (HIPK2) protein target in silico, the expression of hypoxia inducible factor 1 subunit α (HIF1A) increased via viral miRNA and HIPK2 suppression by computer simulation with METS analysis. In addition, MIR2097-5p showed high affinity for 11 SARS-CoV-2 genome sites, including the 5’UTR. As a result, MIR2097-5p would prevent viral proliferation, and serious symptoms of COVID-19 could be remedied by MIR2097-5p. Since in Japan, both the number of patients and that of deaths per million people are much lower than USA, approximate 1/33 and 1/50, respectively. There are significant differences in the geographic distribution of infected patients between Asia and Europa/America. The cause of this regional difference in the number of patients and deaths per million people in Japan and USA may be due to the staple rice diet in Japan. Conclusion: Thus, we found plant MIR2097-5p, a candidate for a ‘quantum miRNA agent’ against COVID-19.
A Review on: Lumpy Skin Disease: Enhance Awareness on the Epidemiological situation and Diagnosis; Prevention and Control Measures in Ethiopia
Authors: G Zewdie
Published: September 2022

Lumpy skin disease (LSD) is an economically significant viral disease of cattle and caused by lumpy skin disease virus (LSDV). The virus is belonging to the genus Capri poxvirus (CaPV) of the family Poxviridae. Recently, the disease has been rapidly spreading to the Middle East, South east Europe and parts of Russian federation. The disease causes significant economic loss due to hide damage, loss of milk production, mastitis, infertility and death. Clinically, LSD is characterized by circumscribed skin nodules, fever, and abortions in females and sterility in males. LSD damages hides and causes death due to secondary bacterial infections. LSD is principally transmitted by blood-feeding arthropod vectors. However, transmission of the disease between animals is inefficient. Diagnosis is mainly based on observation of clinical signs and identification of the agent using conventional and real-time PCR methods, electron microscopy, and isolation of the virus in cell cultures, and using conventional serological tests. In endemic countries, vaccination is the only effective method to control the disease using live attenuated vaccines derived from Kenyan sheep and goat pox virus (KSGP) strains. However, there are reports of insufficient protection of the existing vaccines. Therefore; there is a need for more extensive data from the field and for larger-scale clinical trials to ensure the efficacy and safety of the current vaccines
Analisis Produktivitas Alat Berat Dan Biaya Pekerjaan Pemindahan Tanah Pada Pembangunan RSUD Pondok Aren Tangerang Selatan
Authors: Listyawan Anto Budi , Sahid Muhammad Nur , Mulyono Gotot Slamet , Fadhlullah Hanry Khairurizal
Published: September 2022

Proyek pembangunan RSUD Pondok Aren menggunakan alat-alat berat pada dalam pekerjaan tanahnya. Untuk mengetahui kemampuan alat berat dalam setiap pekerjaan perlu dilakukan analisis alat berat excavator Komatsu PC50, excavator Hitachi Zx 210-5, three wheel roller Sakai KD7610 dan dump truck Colt FE SHD yang digunakan sehingga dapat mengetahui jumlah produktivitas dan biaya alat berat. Dalam penelitian ini dilakukan analisis untuk mendapatkan besarnya produktivitas, waktu, dan biaya alat berat berdasarkan data rencana dan data saat pelaksanaan untuk dilakukan perbandingan antara saat perencanaan dan pelaksanaan. Berdasarkan hasil analisis didapatkan produktivitas alat berat berdasarkan data pabrikasi lebih besar dibandingkan dengan saat pelaksanaan sehingga pada pelaksanaan dibutuhkan waktu 95 hari lebih lama dibandingkan waktu rencana. Besarnya biaya yang dikeluarkan pada pelaksanaan sebesar Rp 205.800.000 sedangkan pada perencanaan sebesar Rp.559.397.556 dengan selisih biaya pelaksanaan dan biaya perencanaan sebesar Rp 353.597.556 dimana biaya pada pelaksanaan lebih murah dibandingkan dengan perencanaan.
Deteksi Konflik Pada Perencanaan Struktur Gedung Bertingkat Dengan Software Revit Dan Navisworks Manage
Authors: Pradiptha Ariani Agung , Pangestuti Endah Kanti
Published: September 2022

Perangkat lunak dalam bidang atau sektor Architecture, Engineering, and Construction (AEC Industry) kini mulai mengalami banyak perkembangan dalam rangka meminimalkan kesalahan pekerjaan manual oleh manusia. Usaha untuk mengantisipasi adanya kekeliruan suatu perencanaan konstruksi (sebagai contoh yaitu pembangunan gedung bertingkat), dapat dideteksi sedari awal melalui fitur-fitur yang disediakan dalam software BIM atau Building Information Modeling (dalam hal ini Revit dan juga Navisworks Manage). Adanya teknologi BIM (Building Information Modeling) yang mampu melakukan deteksi sedari awal terhadap ada/tidaknya suatu clash atau konflik antar sistem struktur maupun dengan sistem yang lainnya menjadikan teknologi BIM ini mampu mengantisipasi/meminimalisir adanya pekerjaan ulang atau tambahan ketika telah dilaksanakan pembangunan di lapangan. Tujuan dilakukannya penelitian ini yaitu untuk menganalisis adanya temuan clash atau konflik pada perencanaan struktur gedung bertingkat dengan software yang digunakan yaitu Revit dan Navisworks Manage. Alur identifikasi deteksi konflik dapat dilakukan dengan terlebih dahulu membuat pemodelan di Revit dengan data gambar rencana yang telah dikumpulkan, kemudian model tersebut di-input ke dalam software Navisworks Manage. Di dalam Navisworks dapat digunakan fitur Clash Detective untuk mengidentifikasi konflik antar struktur bangunan. Ditemukan adanya empat clashes pada sistem struktur fondasi dengan struktur balok. Bagian yang mengalami konflik ada pada salah satu bagian fondasi dengan dua balok pada lantai satu. Pada sistem struktur kolom dan balok, ditemukan adanya dua clashes. Konflik terjadi pada bagian di antara kolom yang terdapat di lantai satu dengan balok yang ada pada lantai dua. Navisworks Manage memberikan informasi detail mengenai konflik yang terjadi dalam bentuk tabel sehingga dapat dilihat kembali letak/koordinat bagian struktur yang mengalami konflik. Pada sistem struktur fondasi dengan struktur kolom, struktur kolom dengan pelat, serta struktur balok dengan pelat tidak ditemukan adanya konflik.
Optimasi Semen Pada Pembuatan Batu Bata Tanpa Bakar
Authors: Widodo Bambang , Artiningsih Ni Komang Ayu
Published: September 2022

Batu bata merupakan bahan utama dalam pekerjaan pasangan dinding batu bata, oleh karena itu perlu diperhatikan dalam penyediaannya dengan mutu atau kualitas yang baik. Penelitian ini bertujuan untuk mengetahui nilai mutu bata dengan mengetahui nilai kuat tekan bata dengan menggunakan campuran antara semen dan tanah lempung tanpa proses pembakaran. Proses pengerasan bata dilakukan pengeringan selama (7) tujuh hari dalam suhu kamar dan kering oven selama 24 jam dengan suhu 40ºC. Metoda penelitian ini adalah membuat percobaan bata dengan tanah lempung yang dicampur semen portland type I, dengan berbagai proporsi campuran semen sebesar 0%, 5%, 10%, 20%, dan 30%. Sampel dalam penelitian ini diperoleh dari Kecamatan Gunungpati Kota Semarang, dengan spesifikasi Berat jenis tanah 2.65, batas cair (LL) 44.5 %, batas plastis (PL) 29.87 % dan indeks platisitas (PI) 14.63 %, kadar air kering udara 44.5 %.  Hasil penelitian menunjukkan bahwa untuk bata semen-lempung tanpa pembakaran dengan prosentase campuran semen sebesar 17% merupakan prosentase yang optimal dengan kekuatan tertinggi yaitu sebesar 52 kg/cm2.
Review Model Waktu Pelaksanaan Konstruksi Bandara Sultan Aji Muhammad Sulaiman (SAMS) Sepingan
Authors: Yanti Yanti , Magfirona Alfia
Published: September 2022

Landasan pacu merupakan salah satu hal sederhana yang minimal dimiliki oleh bandar udara sebagai jalur perkerasan yang dipergunakan oleh pesawat terbang untuk mendarat (landing) dan melakukan lepas landas (take off). Kualitas landasan pacu diharapkan dapat memberikan kenyamanan dan keselamatan penerbangan sebagai infrastruktur yang digunakan untuk akses utama pesawat terbang dalam melakukan pergerakan. Metode penelitian ini menggunakan metode kualtitatif, studi literatur, serta kajian model SmartPLS. Berdasarkan hasil studi literature yang dilakukan diperoleh beberapa faktor yang mempengaruhi pelaksanaan proyek konstruksi meliputi pembebasan lahan, rehabilitasi, izin lingkungan, teknologi atribut, klien, kontraktor, konsultan berdasarkan frekuensi, tingkat keparahan, indeks kepentingan, dan kebutuhan tim proyek dari semua pemangku kepentingan. Selain itu, pada proyek bandara beberapa hal yang berpengaruh terkait dengan pengembangkan model kuantitatif yang mengintegrasikan beberapa elemen yang relevan dalam perencanaan MR trotoar landasan pacu bandara, analisis secara visual kerusakan landasan pacu dengan PC serta perampingan informasi yang berpengaruh dalam implementasi sistem berbasis web pada proyek, serta analisis dimensi kualitatif (penyebab penundaan) dan kuantitatif (kinerja waktu) dari masalah penundaan menggunakan dua indikator yaitu Reason for Noncompliance (RNC) sebagai penyebab keterlambatan dan Delay Index (DI) sebagai indikator penundaan. Oleh karena itu, dilakukan penelitian review ini untuk menentukan variabel yang dapat dianalisis dengan smartPLS untuk menentukan berapa besar pengaruh faktor tersebut.
Pemanfaatan Limbah Plastik dengan Teknologi Daur Ulang pada Hot Rolled Asphalt Ditinjau dari Aspek Properties Marshall, Nilai Ketidakrataan, dan Durabilitas
Authors: Riyanto Agus , Pramesti Yan
Published: September 2022

Hot Rolled Asphalt (HRA) merupakan campuran aspal – agregat bergradasi senjang yang memiliki workablitas tinggi sehingga mudah dalam pengerjaannya. Penelitian ini menggunakan aditif limbah plastik jenis PET (Polietilena Tereftalat) sebagai aditif. Tujuan penelitian ini untuk mencari nilai KPO (Kadar Plastik Optimal), Properties Marshall, Nilai Ketidakrataan, dan Durabilitas campuran. Penelitian menggunakan data primer dan data sekunder. Data primer merupakan hasil dari pengujian ekstraksi, aspal, dan agregat oleh peneliti, sedangkan data sekunder didapatkan dari BPPJN VII, 2020. Membuat benda uji dengan kadar aspal 7%, 8%, dan 9% masing-masing 2 sampel untuk mendapatkan nilai Kadar Aspal Optimum (KAO). Dilanjutkan membuat benda uji dengan penambahan limbah plastik dengan kadar 0%, 2%, 4%, dan 6% terhadap nilai KAO masing-masing 2 sampel untuk mencari nilai Kadar Plastik Optimum (KPO). Dilakukan pengujian volumetric, uji Marshall test untuk mendapatkan nilai KPO, dilanjutkan membuat benda uji untuk mencari nilai ketidakrataan dan durabilitas campuran. Hasil penelitian dengan penambahan limbah plastik pada campuran didapatkan KPO sebesar 4,7% dengan Stabilitas 2133,67 kg, flow 3,67 mm, VFWA 83,48 %, VMA 21,13 %, VIM 3,49 %, dan MQ 499,76 kg/mm. Didapatkan nilai ketidakrataan sebesar 1,692 m/km sehingga menurut indikator kondisi perkerasan jalan benda uji termasuk dalam kondisi baik. Penambahan limbah plastik meningkatkan nilai Indeks Kekuatan Sisa (IKS) sebesar 91,60% dengan spesifikasi IKS yaitu 80% dari nilai stabilitas normal sehingga campuran dinyatakan durabel. Hasil penelitian ini, campuran HRA dengan penambahan limbah plastik dapat meningkatkan kekuatan dan mengurangi nilai ketidakrataan pada lapis perkerasan, serta mengurangi jumlah limbah plastik yang ada di Indonesia.
Perencanaan Fondasi Tiang Pancang Pada Gedung Perkuliahan Universitas Slamet Riyadi (Variasi Diameter Tiang Pancang)
Authors: Wiqoyah Qunik , Nugroho Iwan Setyo
Published: September 2022

Uji sondir dilakukan pada 3 titik di lokasi pembangunan Gedung perkuliahan Universitas Slamet Riyadi. Didapatkan bahwa tanah keras terletak pada kedalaman 4,4 m dari permukan tanah. Berdasarkan hasil uji sondir tersebut maka jenis fondasi yang digunakan dalam perencanaan ini adalah pondasi tiang pancang beton dengan 3 jenis variasi diameter yaitu dengan diameter 0,3; 0,4; 0,5 m dengan kedalaman tiang 4 m. Tujuan dari perencanaan ini adalah menentukan beban struktur yang diterima oleh fondasi, mendesain jumlah tiang pancang yang dibutuhkan, mendesain penulangan pada Pile Cap serta penulangan tiang pancang. Perencanaan diawali dengan menentukan beban struktur yang diterima oleh fondasi, mendesain jumlah tiang pancang yang dibutuhkan, mendesain penulangan pada Pile Cap serta penulangan tiang pancang. Hasil perhitungan kapasiktas dukung tiang pancang mengunakan metode Meyerhof pada tanah pasir dan metode deRuiter dan Beringen pada tanah lempung didapatkan hasil sebagai berikut : untuk tiang diameter 0,3 m sebesar 534,856 kN, diameter 0,4 m sebesar 780,257 kN, diameter 0,5 m sebesar 827,689 kN. Perhitungan beban struktur atas didapatkan nilai beban aksial kolom terbesar 2293,510 kN. Jumlah tiang pancang yang dibutuhkan diameter 0,3 m jumlahnya 6 tiang, diameter 0,4 dan 0,5 m sebanyak 4 tiang.
Tinjauan Kuat Dukung Tanah Lempung Bayat – Klaten dengan Bahan Stabilisasi Slag Baja
Authors: Susanto Agus , Monico Krisindo , Renaningsih Renaningsih
Published: September 2022

Berdasarkan penelitian tanah dari Desa Talang Kidul, Kecamatan Bayat, Klaten merupakan tanah lempung dengan nilai plastisitas yang tinggi dikarenakan nilai PI nya 17 %. Perbaikan dilakukan dengan bahan tambah slag baja. Penambahan campuran slag baja dengan persentase 0%,5%,10%, dan 15%, dan adanya variasi ukuran butiran slag baja lolos saringan No.4 dan No.40 bertujuan untuk mengetahui sifat fisis dan mekanisnya. Hasil pengujian mekanis diperoleh Nilai berat volume kering maksimum terbesar pada penambahan 15% No.40 sebesar 1,57 gr/cm3, sedangkan berat volume kering maksimum tanah campuran slag baja terkecil pada panambahan 5% No.4 yaitu 1,41 gr/cm. Nilai kadar air optimum paling besar didapat 21% pada slag baja 5% No.4, sedangkan nilai kadar air optimum paling kecil didapat pada slag baja 15% No.40 sebesar 19%. Semakin kecil ukuran slag baja, nilai berat volume kering maksimum mengalami peningkatan dan nilai kadar air optimumnya mengalami penurunan. Semakin kecil ukuran slag baja menyebakan nilai CBR semakin meningkat. Dan untuk pengujian nilai pengembangan tanah (swelling) pada tanah asli sebesar 1,53. Penambahan campuran slag baja No.4 dan No.40 menyebabkan nilai pengembangan (swelling) mengalami penurunan. Hasil dari nilai pengembangan yang terendah pada slag baja 15% No.40 sebesar 1,20 %. Semakin kecil ukuran butiran slag baja, semakin kecil nilai pengembangan (swelling).
A FORMAÇÃO CONTINUADA DO PROFESSOR DE CIÊNCIAS E BIOLOGIA DA EDUCAÇÃO BÁSICA: UMA PROPOSTA USANDO COLEÇÕES BIOLÓGICAS
Authors: Lobato Lima Nayra Rafaela , Charles da Silva Natanael , Miranda Costa Jeferson , Vasconcelos Montenegro Adauto de
Published: September 2022

Na busca pela qualidade do processo formativo contínuo, melhoria na carreira e valorização docente, o objetivo desta pesquisa foi propor um modelo de formação continuada de professores de Ciências e Biologia da Educação Básica, utilizando elementos de uma coleção biológica como recurso didático, bem como discutir sobre a necessidade de formação continuada desses profissionais a parir da percepção dos professores cursistas. O curso de formação continuada ocorreu no Instituto Federal do Pará, Campus Abaetetuba, durante três dias, com a participação de 20 professores e com carga-horária de 20 horas de atividades. Após a formação, foi possível construir uma estrutura para a proposta do curso, contendo as características gerais, temas abordados, métodos utilizados, cronograma de execução e método avaliativo. Com a pesquisa, ficou evidente a necessidade e importância na realização de ações voltadas para a formação continuada professoral, utilizando recursos metodológicos diversificados e, principalmente, tendo como base a vivência socioambiental dos docentes e discentes envolvidos.
Comparative Research on the Low-Carbon Urban Block Morphological Design
Authors: Xia Bing , Pan Shengzhang
Published: September 2022

Reducing carbon emissions to mitigate global warming is a major problem facing mankind. Since city is the main region of global carbon emission, it is of great significance to promote low-carbon development and build low-carbon city. The urban block scale is the key aspect of the construction of low-carbon city, thus the scientifically compiled urban design guidelines have a kind of quite essential practical guiding value for the construction of low-carbon cities. For this reason, the shortcomings of the methods are summarized in this paper through combing, comparing and analyzing the relevant literature from four aspects of calculation and evaluation of carbon emission in block scale, carbon emission and block shape, optimization design method of low carbon block shape, scientific guidance and control of low carbon block form. Furthermore, the key issues, main problems to be solved and aims of future study are discussed.
PEMANFAATAN POWTOON SEBAGAI MEDIA PEMBELAJARAN YANG KREATIF DAN INTERAKTIF
Authors: Ayuningtyas Ayuningtyas , Suhandiah Sri
Published: September 2022

Generasi Z merupakan generasi yang sangat paham pada teknologi dan memiliki kemampuan visual yang baik. Pembelajaran yang disampaikan oleh guru-guru jika tanpa melibatkan teknologi dalam penyampaiannya kurang disukai oleh generasi ini. Di sisi lain, secara umum permasalahan yang dirasakan oleh guru-guru SMA Tanada Surabaya adalah kurangnya pengetahuan dan keterampilan untuk membuat materi pelajaran yang menarik. Permasalahan ini kemudian diselesaikan dengan memberikan pelatihan pembuatan materi ajar yang menarik dengan menggunakan aplikasi animasi video online Powtoon. Pelatihan dilakukan dengan tiga tahapan kegiatan, pertama tahap persiapan dengan studi literatur dan pembuatan modul, kedua tahap pelaksanaan pelatihan yang dilakukan dalam dua sesi, dan tahap akhir yaitu tahap evaluasi. Dari pelatihan ini dapat disimpulkan bahwa pelatihan yang dilakukan dapat menambah wawasan pengetahuan dan keterampilan guru-guru dalam membuat materi ajar berbasis video animasi. Selain itu, dengan adanya rancangan kegiatan maka pelatihan dapat berjalan dengan lancar dan modul pelatihan yang diberikan dapat dipahami oleh seluruh peserta dengan baik.
Introduction to questionnaire data patterns using Perceptron Algorithm for lecturer improvement and development in higher education
Authors: Irwan Irwan , Putra Rusnardi Rahmat , Krismadinata Krismadinata , Jalinus Nizwardi
Published: September 2022

This artificial neural network research article aimed to overview the current teaching process focusing on lecturer performance using the perceptron algorithm, improving the teaching process, developing the lecturer based on the perceptron algorithm's results, evaluating the speed and accuracy of the perceptron algorithm in evaluating performance lecturer and learning the rules of the perceptron algorithm in processing assessment criteria for lecturers in tertiary institutions. In this case, the perceptron algorithm was used to recognize the questionnaire data input patterns. The perceptron algorithm was trained and tested to recognize input data patterns so that this neural network could identify input data patterns from questionnaire data.
Ideal mortar composition with rice husk ash addition and addictive for maximum mortal strength
Authors: Putra Rusnardi Rahmat
Published: September 2022

The intensity of earthquakes increases from time to time both in number and in strength; recently, in Indonesia, damage to buildings by earthquake acceleration usually begins with damage to walls. Besides having a function as a barrier between spaces in construction, walls also have an essential role in increasing a building structure's rigidity. Mortar, which is usually used as a wall and plastering, has a role as a binder between the walls themselves' components so that quality mortar will help the walls be stronger. This research aims to produce the ideal mortar mixture with low price, high quality, and easy to obtain material. The proposed added composition was husk ash and Fosroc SP 337 additive, varied based on cement's weight. The yield of mortar with added ingredients will be compared with ordinary mortar without added ingredients. The specimens' manufacture used 20 samples of 5cm x 5cm x 5cm cubes with five variations of mortar composition, and mortar compressive strength testing was carried out at 7, 14, and 28 days of age. The maximum compressive strength obtained for mortar with the addition of 15% rice husk ash, 1% fosroc sp 337, and the combination of the two experienced an increase in the compressive strength value, the ratio of the average compressive strength of the mortar, the highest average compressive strength results in the mixture 1 PPC cement: 4 Sand with the addition of 15% rice husk ash: 1% fosroc sp 337 with an average compressive strength yield of 116.6 kg / cm² at the age of 7 days, 145.6 kg / cm² at the period of 14 days and 154.6 kg / cm² at the age of 28 days.
Portable power supply design with 100 Watt capacity
Authors: Azhari Zakri Azriyenni , Syahza Almasdi , Hanafi Dirman , Syahadat Hanggun
Published: September 2022

Renewable energy from solar cells is a type of alternative energy for consumers, especially those far from electricity, and saves electrical energy. This research developed an innovative tool for portable solar power generators as a source of energy, which stores electrical energy in two ways, namely solar cells and transformers. Furthermore, this research is expected to improve innovation tools for more efficient electricity supply and energy use, especially for rural communities. It also uses a variety of battery capacities to test portable power supplies. The results showed that the power supply using 100 Wp solar cells produced a capacity of 20 Ah, 60 Ah, and 100 Ah on the battery. Charging with a solar energy source on a 20 Ah battery takes a duration of 5 hours to be fully charged, while 60 Ah and 100 Ah batteries cannot be fully charged in one day. Charging a battery that has been run at a full level takes a duration of 15 hours at a temperature of 30oC to 34oC. Finally, this tool is expected to add variety to locally manufactured products.
ICT portal for the development of mathematic teachers competence: The development and the feasibility
Authors: Marzal Jefri , Syafmen Wardi , Sabil Husni
Published: September 2022

One of the problems in improving the competence of Information and Communication Technology (ICT) for mathematics teachers is that the teacher has to leave his / her teaching activities to participate in various improving competence events. This study aims to develop an ICT house portal that will be managed by the Mathematics Subject Teacher Forum in Indonesia or known as MGMP  that allows teachers to interact with fellow teacher communities to improve ICT competence without having to leave their teaching activities at school. Furthermore, the researchers also conducted a usability test of the developed portal. The application development model used is the ADDIE model which stands for Analysis, Design, Development, Implementation, Evaluation. Meanwhile, application usability testing was carried out by distributing usability questionnaires to 30 respondents consisting of postgraduate students and lecturers of mathematics education. The results showed that the ADDIE model can be used to design and create the ICT house portal called RumahTIK where the procedures in the development section include making applications, testing by experts, testing content filling, testing the use of clinical features. Based on the results of the usability questionnaire processing, the percentage of usability was 81% which was classified as very feasible. Although this research was not implemented for real teacher groups, the ICT house portal is very suitable for use by the MGMP group. In the future, it is necessary to implement this portal in various MGMP groups so that recommendations can be obtained to improve teachers' ICT competence in mathematics.
The influence of project based learning on student's intrinsic learning motivation
Authors: Muslim Muslim , Saputra Hendra Dani , Setiawan Muhammad Yasep , Martias Martias , Nasir Muhammad
Published: September 2022

The lack of total student involvement in the learning process is due to a lack of effort in finding information independently and not achieving active learning. The purpose of this study was to investigate the effect of intrinsic motivation on project-based learning in the automotive engineering education student workforce transfer system course. The method used was a quasi-experimental research design with a 2x2 factorial. The population used was students of the Automotive Engineering Department, Faculty of Engineering, Padang State University, 2020/2021 academic year. The results showed that students who applied project-based learning had higher learning outcomes than using conventional methods. This was based on the value of Fcount greater than Ftable, 7.866 > 3.34 at the 0.05 significance level. There is an interaction between learning methods and students' intrinsic motivation towards learning outcomes, this is evidenced by the value of Fcount is greater than Ftable, 7.602> 3.34 at the 0.05 significance level. There is a significant difference in student learning outcomes between project-based learning and conventional learning which has high intrinsic motivation. The final research result is that there is no significant difference in student learning outcomes between project-based learning and conventional learning which has low intrinsic motivation
Structural assessment of building Elementary School 28 Air Tawar Timur Padang
Authors: Putri Prima Yane , Candra Candra
Published: September 2022

Abstrak ˗˗ Sekolah Dasar Negeri 28 Air Tawar Timur Padang termasuk Sekolah Inpres yang dibangun pada tahun 1982. Kondisi bangunan sekolah saat ini mengalami kerusakan seperti retak (crack), lepasnya bagian beton (spalling), lendutan dan lantai yang bergetar. Penelitian ini bertujuan untuk memberikan rekomendasi perbaikan atau perawatan pada bangunan sekolah tersebut. Metode assessment yang digunakan dalam penelitian ini adalah metode NonDestructive Test (NDT). Pengujian kuat tekan beton menggunakan alat Schmidt Rebound Hammer. Untuk mengetahui jumlah baja tulangan, diameter baja tulangan serta dimensi elemen struktur menggunakan alat Rebar Locator, Kaliper, dan meteran. Pengujian geometri bangunan dan lendutan pelat lantai menggunakan alat Total Station dan Laser Measurement. Struktur bangunan dianalisis menggunakan program SAP2000. Hasil pengujian kuat tekan beton (fc’) rata-rata sebesar 20,40 MPa pada kolom, 22,23 MPa pada balok, dan 23,43 MPa pada pelat lantai.Hasil pengamatan visual bangunan termasuk kategori rusak berat dengan persentase kerusakan diatas 20%. Dimana tingkat persentase kerusakan kolom sebesar 32%, balok 20,35%, dan pelat lantai 65%. Hasil evaluasi struktur bangunan menunjukan hampir semua elemen termasuk kategori tidak aman kecuali Balok 3, Balok 4, dan Kolom 2. Lendutan maksimum pelat lantai sebesar 73 mm melebihi lendutan izin yaitu 18,9 mm. Rekomendasi perbaikan sekolah tersebut adalah renovasi bangunan.
Cultural and Social Welfare Approaches in Komodo National Park To Support National Security
Authors: Safarani Jeihany Anggrilla , Adriyanto Agus , Saragih Herlina Juni Risma
Published: September 2022

Komodo National Park is a medium in maintaining national identity to support the implementation of national defense and maintain national security. Komodo National Park is one of five national parks that were first designated in Indonesia with the main icon being the endemic animal, the Komodo. Then, the Government runs this park management model using a participatory approach to tourism development accompanied by the provision of training to develop human resources, capital assistance, to equipment assistance which is synergized and integrated with environmental care institutions and conservation organizations. This research uses a qualitative approach with a literature study by searching and studying various literatures related to culture and welfare in Komodo National Park so that the data in this study uses secondary data. The legacy of the Ora legend that provides behavioral construction to the local community until the next generation builds a sense of belonging among the people to maintain the unity of Indonesia and live peacefully side by side with Komodo according to the provisions of the zoning area. This is the basis for how the government carries out development efforts with community participation which is accommodated in activities that accommodate creativity, interest, and potential such as creative economic training to improve the level of community welfare. The conclusion in the research: national security which is manifested in the management of Komodo National Park describes the societal security and environmental security sectors.
IMPLEMENTASI CONTINUOUS INTEGRATION/CONTINUOUS DELIVERY (CI/CD) PADA PERFORMANCE TESTING DEVOPS
Authors: Jaeni Jaeni , S. Nicko Aji , Laksito Arif Dwi
Published: September 2022

Secara umum proses pengembangan aplikasi terdiri dari proses perancangan, pengujian, dan deployment. Pengembangan dengan cara tradisional seringkali menimbulkan masalah seperti keterlambatan aplikasi dan kualitas produknya. Hal ini dapat terjadi karena tim operasional harus menunggu developer agar menyelesaikan proses uji coba terlebih dahulu sebelum aplikasi tersebut dapat dirilis dan diguankan. Selain itu, setelah proses pengujian selesai, sering didapati adanya konflik akibat environment yang berbeda, yang memperlambat proses rilis. Keterlambatan ini membuat klien kecewa dan memberikan efek yang tidak baik bagi perusahaan. Continuous Integration / Continuous Delivery (CI/CD) dapat dijadikan solusi untuk memecahkan masalah ini. CI/CD dapat menjadi jembatan antara tim pengembang dan tim operasional..
 
Kata Kunci:
Continuous Integration, Continuous Delivery, Gitops, Perfomance testing