bluuebunny/crossref_metadata_2025 huggingface dataset:
Interview with Mark Anderson
Authors: Atzenbeck Claus
Published: March 2023

Mark Anderson has worked in the creation and support of information systems for over 40 years. In 2013 he returned to formal study, completing an MSc and PhD in Web Science at Southampton University, looking at sustaining organisations' knowledge held in hypertext. He is now a visiting fellow in the WAIS Group at the University of Southampton. He has previously worked in a range of careers: firstly as a signals officer in the Royal Navy, then co-founding an online start-up in the mid-90s, and latterly as a specialist metadata and Tinderbox consultant.

During his PhD studies, he worked on saving old hypertext systems of note (most notably, Southampton's Microcosm system). His current research continues to look at organisational knowledge systems that include humans in the loop rather than place complete reliance on computer "AI". He is also involved in a number of public projects to improve the durability of knowledge (including Visual-Meta, which was first trialled at Hypertext'21), as well as continuing to contribute to the recovery of other early hypertext systems---while they can still be found. In other research, he has created an in-conference citation dataset for the Hypertext Conference (1987--2020) and then worked with others to generate visualisations based upon it.

Since 2004 he has been the volunteer support leader for the community of users of the Tinderbox and Storyspace hypertextual tools including writing and maintained Tinderbox's "aTbRef" open documentation. He has also worked on digitisation of Ted Nelson's books to make them more accessible to the post-print generations. Most recently, as part of the Future of Text initiative he is also researching the implications for work in VR.

Mark has a particular interest in issues of spatial hypertext and the employment of multiple views on hypertext data. Mark's formal research work may be found at https://scholar.google.co.uk/citations?user=jn8crEAAAAAJ or https://orcid.org/0000-0001-7396-0721; he can be contacted at mwra1r19@soton.ac.uk or via Twitter @mwra.
Web Perspectives in Robotics Applications
Authors: Conti Christopher J. , Varde Aparna S. , Wang Weitian
Published: March 2023

The realms of commonsense knowledge and reasoning, vehicle automation with full as well as partial autonomy, and human-robot collaboration, present growing areas of research in recent times, with much of the concerned data being disseminated through the Web and devices encompassing IoT (Internet of Things); the data per se being heterogeneous including plain text, images, audiovisuals, hypertext and hypermedia. Due to the advent of autonomous vehicles, there is a greater need for the embodiment of commonsense knowledge within their development in order to simulate subtle, intuitive aspects of human judgment. The field of robotics has often encountered collaborative tasks between humans and robots to enhance the respective activities involved and produce better results than humans or robots would achieve working by themselves. Accordingly, this article outlines and organizes some of the research occurring in these areas along with its Web perspectives and applications. Context related to human-robot collaboration and commonsense knowledge appears via a survey of the literature. Vehicle automation is significant with the relevant studies: its definition and methods of improvement are of focus in the article. Some work in this area makes an impact on smart manufacturing. There is discussion on how human-robot collaboration is beneficial, and how commonsense knowledge is useful for the collaboration to occur in an enhanced manner. This article would be potentially interesting to various communities, e.g. AI professionals, Web developers, robotics engineers, and data scientists.
AcTrak: Controlling a Steerable Surveillance Camera using Reinforcement Learning
Authors: Fahim Abdulrahman , Papalexakis Evangelos , Krishnamurthy Srikanth V. , K. Roy Chowdhury Amit , Kaplan Lance , Abdelzaher Tarek
Published: March 2023

Steerable cameras that can be controlled via a network, to retrieve telemetries of interest have become popular. In this paper, we develop a framework called
AcTrak
, to automate a camera’s motion to appropriately switch between (a) zoom ins on existing targets in a scene to track their activities, and (b) zoom out to search for new targets arriving to the area of interest. Specifically, we seek to achieve a good trade-off between the two tasks, i.e., we want to ensure that new targets are observed by the camera before they leave the scene, while also zooming in on existing targets frequently enough to monitor their activities. There exist prior control algorithms for steering cameras to optimize certain objectives; however, to the best of our knowledge, none have considered this problem, and do not perform well when target activity tracking is required.
AcTrak
 automatically controls the camera’s PTZ configurations using
reinforcement learning (RL
), to select the best camera position given the current state. Via simulations using real datasets, we show that
AcTrak
detects newly arriving targets
30%
faster than a non-adaptive baseline and rarely misses targets, unlike the baseline which can miss up to 5% of the targets. We also implement
AcTrak
to control a real camera and demonstrate that in comparison with the baseline, it acquires about
2×
more high resolution images of targets.
Hot Carrier Injection Reliability of Fabricated N- and P-Type Multi FinFETs with Different TiN Stacks
Authors: Chen Yu-Lin , Yeh Wen-Kuan , Hsu Heng-Tung , Chen Ke-Horng , Lin Wen-Chin , Yu Tien-Han , Chou Hung-Ting , Godwin Raj D , Godfrey D
Published: March 2023

Device degradation due to hot carrier injection (HCI) in multi-fin 20 nm and 10 nm N- and P-type FinFET devices are thoroughly analyzed. To further understand the HCI reliability of the four FinFET devices, the device is fabricated with a standard Vt base and low Vt base gate stacks with different work functions. It is evident that: (i) The standard Vt device sustains lower effective stress bias due to the difference in threshold voltage, resulting in a more stable threshold voltage than the low Vt base device, and (ii) the transconductance of the single N- and P-type FinFET is more severely degraded than the multi-fin N- and P-type FinFET, mainly because multi N- and P-type Finfet has coupe effect, which effectively reduces the impact of HCI.
A Novel Pentachlorophenol Electrochemical Sensor Based on Nickel-Cobalt Layered Double Hydroxide Doped with Reduced Graphene Oxide Composite
Authors: Meskher Hicham , Achi Fethi , Ben Moussa Fatah , Henni Abdellah , Belkhelfa Hakim
Published: March 2023

A highly sensitive non-enzymatic electrochemical pentachlorophenol (5-CP) sensor was successfully fabricated employing a multi-component sensing platform made of nickel-cobalt layered double hydroxide (NiCo-LDH) supported on green organic-inorganic nanohybrid (rGO-CuO) drop-casted on a gold electrode (AuE). The chemical and morphological properties of the as-synthesized nanostructures were investigated and confirmed by infrared spectroscopy (ATR) and scanning electron microscopy (SEM). The electrochemical measurements demonstrated that both the good conductivity of and the large active surface area of the hierarchical structure of NiCo-LDH/rGO-CuO favor the electrochemical redox reaction of 5-CP. In the optimized procedure, we have evaluated the analytical performance of the NiCo-LDH/rGO-CuO/AuE using cyclic voltammetry based on the current intensities of the redox peaks. Our findings indicate that the developed NiCo-LDH/rGO-CuO/AuE sensor exhibits a wide linear range from 1 to 50μM while the limit of detection was estimated to be 12.64 nM for 5-CP. Moreover, the suggested 5-CP sensor displayed an excellent stability that might provide a robust sensing platform for the practical and reliable detection of 5-CP in various real samples.
The Health-Promoting Effects and the Mechanism of Intermittent Fasting
Authors: Liu Simin , Zeng Min , Wan Weixi , Huang Ming , Li Xiang , Xie Zixian , Wang Shang , Cai Yu
Published: March 2023

Intermittent fasting (IF) is an eating pattern in which individuals go extended periods with little or no energy intake after consuming regular food in intervening periods. IF has several health-promoting effects. It can effectively reduce weight, fasting insulin levels, and blood glucose levels. It can also increase the antitumor activity of medicines and cause improvement in the case of neurological diseases, such as memory deficit, to achieve enhanced metabolic function and prolonged longevity. Additionally, IF activates several biological pathways to induce autophagy, encourages cell renewal, prevents cancer cells from multiplying and spreading, and delays senescence. However, IF has specific adverse effects and limitations when it comes to people of a particular age and gender. Hence, a more systematic study on the health-promoting effects and safety of IF is needed. This article reviewed the research on the health-promoting effects of IF, providing a theoretical basis, direction for subsequent basic research, and information related to the clinical application of IF.
Synthesis and Characterization of Hydrogel-Based Hyaluronic Acid-Chitosan-Allium sativum Extract for Intraperitoneal Antiadhesion Application
Authors: Widiyanti Prihartini , Priskawati Yolanda Citra Ayu
Published: March 2023

Peritoneal Adhesion is a severe case that frequently occurs in patients after laparotomy surgery. Adhesions are pathological attachment that usually appears between the omentum, intestine, and abdominal wall. Several barriers are made to prevent adhesions, including liquid barriers such as sodium hyaluronate and carboxymethyl cellulose (CMC) but are fast absorbed-time hydrogel. The solid barrier has weakness of difficulty in covering all parts of the wound surface. The study aims to synthesize degradable hydrogel from N,O-Carboxymethyl Chitosan (NOCC), Aldehyde-Hyaluronic Acid, and the addition of Allium sativum (garlic oil). The best sample with the concentration of A-HA/NOCC 30 : 10 g/ml was obtained. The composite hydrogel of NOCC/AHA/Allium sativum has susceptible antimicrobial properties. In vitro cytotoxicity assay showed that hydrogel is nontoxic. The degradation time is for two weeks. The in vivo evaluation in a mouse model with an abrasion defect side was done to identify the effectiveness of the NOCC/AHA/A. sativum as antiperitoneal adhesion. Seven days after surgery, the observation of adhesion was performed. Based on all assay results, it can be resumed that the NOCC/AHA/A. sativum hydrogel possibly acts as an innovation to prevent postoperative intraperitoneal adhesion.
Hospitalised Smokers’ and Staff Perspectives of Inpatient Smoking Cessation Interventions and Impact on Smokers’ Quality of Life: An Integrative Review of the Qualitative Literature
Authors: Epton Leah , Patman Shane , Coventry Tracey , Bulsara Caroline , Ward Kenneth
Published: March 2023

Aim. To identify, integrate, and appraise the evidence on hospitalised smokers’ and staff perspectives of inpatient smoking cessation interventions and the impact on smokers’ quality of life. Design. The integrative review method was used to present hospitalised smokers’ and staff perspectives of inpatient smoking cessation interventions. Search Method. This integrative review consisted of a comprehensive search on smoking cessation interventions that take place during an inpatient admission to hospital for adults (> age 18 years) of the following online databases: Ovid Medline, Joanna Briggs Institute, APA PsycInfo, CINAHL, Cochrane, Google Scholar, PEDro, and Scopus. The search strategy was inclusive of peer-reviewed studies limited to the English language or translated to English. A search of grey literature and manual searching of reference lists was also conducted to identify further studies not identified in the online database search. All studies that produced any qualitative data (i.e., qualitative, mixed methods, and surveys) on inpatient-initiated smoking cessation programs were included. Outcomes of interest are included but were not limited to education, counselling, and the use of pharmacotherapy. Studies undertaken in the psychiatric, adolescent, and paediatric settings were excluded. Results. The key findings from this integrative review included positive evaluations from both patients and staff involved in inpatient smoking cessation interventions, reporting that hospitalisation was an appropriate opportunity to address smoking cessation. A number of facilitators and barriers to inpatient smoking cessation interventions included creating a supportive patient-centred environment and consideration of the cost of nicotine replacement therapy and time to deliver inpatient smoking cessation interventions. Recommendations/preferences for future inpatient smoking cessation interventions included the use of a program champion and ongoing education to demonstrate the effectiveness of the intervention, and despite the cost of nicotine replacement therapy being identified as a potential barrier, it was identified as a preference for most patients. Although quality of life was only evaluated in two studies, statistically significant improvements were identified in both. Conclusion. This qualitative integrative review provides further insight into both clinician and patient participants’ perspectives on inpatient smoking cessation interventions. Overall, they are seen to produce positive benefits, and staff training appears to be an effective means for service delivery. However, insufficient time and lack of resources or expertise appear to be consistent barriers to the delivery of these services, so they should be considered when planning the implementation of an inpatient smoking cessation intervention.
Antitumor Therapy Targeting the Tumor Microenvironment
Authors: Gao Yuewen , Pan Zhengwu , Li Hongqi , Wang Fei
Published: March 2023

The development and progression of tumors in human tissues extensively rely on its surrounding environment, that is, tumor microenvironment which includes a variety of cells, molecules, and blood vessels. These components are modified, organized, and integrated to support and facilitate the growth, invasion, and metabolism of tumor cells, suggesting them as potential therapeutic targets in anticancer treatment. An increasing number of pharmacological agents have been developed and clinically applied to target the oncogenic components in the tumor microenvironment, and in this review, we will summarize these pharmacological agents that directly or indirectly target the cellular or molecular components in the tumor microenvironment. However, difficulties and challenges still exist in this field, which will also be reported in this literature.
Identification and Validation of a Necroptosis-Related Prognostic Signature for Kidney Renal Clear Cell Carcinoma
Authors: Cai Manbo , Yang Qiao , He Junyan , Wu Haibiao , Li Zhimin , Fang Zhe , Li Jianjun
Published: March 2023

Background. Necroptosis is progressively becoming an important focus of research because of its role in the pathogenesis of cancer and other inflammatory diseases. Our study is designed to anticipate the survival time of kidney renal clear cell carcinoma (KIRC) by constructing a prognostic signature of necroptosis-related genes. Materials. Clinical information and RNA-seq data were acquired from Renal Cell Cancer-European Union (RECA-EU) and The Cancer Genome Atlas- (TCGA-) KIRC, respectively. ConsensusClusterPlus was used to identify molecular subtypes, and the distribution of immune cell infiltration, anticancer drug sensitivity, and somatic gene mutations was studied in these subtypes. Subsequently, LASSO-Cox regression and univariate Cox regression were also carried out to construct a necroptosis-related signature. Cox regression, survival analysis, clinicopathological characteristic correlation analysis, nomogram, cancer stem cell analysis, and receiver operating characteristic (ROC) curve were some tools employed to study the prognostic power of the signature. Results. Based on the expression patterns of 66 survival-related necroptosis genes, we classified the KIRC into three subtypes (C1, C2, and C3) that are associated with necroptosis, which had significantly different tumor stem cell components. Among these, C2 patients had a longer survival time and enhanced immune status and were more sensitive to conventional chemotherapeutic drugs. Moreover, in order to predict the prognosis of KIRC patients, five genes (BMP8A, TLCD1, CLGN, GDF7, and RARB) were used to develop a necroptosis-related prognostic signature, which had an acceptable predictive potency. The results from Cox regression and stratified survival analysis revealed that the signature was an independent prognostic factor, whereas the nomogram and calibration curve demonstrated satisfactory survival time prediction based on the risk score. Conclusions. Three molecular subtypes and five necroptosis-related genes were discovered in KIRC using data from TCGA-KIRC and RECA-EU. Thus, a new biomarker and a potentially effective therapeutic approach for KIRC patients were provided in the current study.
Awareness of Dysphagia-Related Complications and Risks and the Importance of Early Intervention in Patients with Parkinson’s Disease: A Qualitative Study
Authors: Yao Kaifeng , Wang Lihua , Zhang Lihua
Published: March 2023

Objective. To investigate the awareness of dysphagia-related complications and risks and the importance of early intervention in patients with Parkinson’s disease (PD). Methods. Using the phenomenological approach of the qualitative study, 18 patients with PD in a Grade A tertiary hospital in Nantong were selected, and semistructured personal in-depth interviews were conducted. The interview content was analyzed using Colaizzi’s seven-step method, and the topics and subtopics were further refined. Results. Awareness of dysphagia-related complications and risks and the importance of early intervention in patients with PD can be summarized into three topics: lack of knowledge about PD and dysphagia, changes in emotional cognition, and low need for early intervention for dysphagia. Conclusions. Patients with PD have a low awareness of dysphagia, do not follow any preventative measures, and have difficulty in recognizing the disease symptoms; hence, there is a vital need for early intervention. Medical staff need to create awareness among patients and their families, provide health education through multiple channels, popularize the knowledge of PD complications such as dysphagia, improve patient compliance with respect to medication, regular consultation, and medical treatment, guide the transformation of negative emotions in patients to positive emotions, and help patients with PD to actively prevent dysphagia and other complications and improve their quality of life.
Delayed Perforation of Colorectal Endoscopic Submucosal Dissection Treated by Endoscopic Ultrasound-Guided Drainage
Authors: Hamada Koichi , Shiwa Yoshiki , Kurita Akira , Todate Yukitoshi , Horikawa Yoshinori , Techigawara Kae , Ishikawa Masafumi , Nagahashi Takayuki , Takeda Yuki , Fukushima Daizo , Nishino Noriyuki , Sakuma Hideo , Honda Michitaka
Published: March 2023

We report a case of a 70-year-old male with delayed perforation in the cecum treated by endoscopic ultrasonography-guided drainage for a pelvic abscess. The lesion was a 50-mm laterally spreading tumor, and endoscopic submucosal dissection (ESD) was performed. No perforation was detected during the operation, and en bloc resection was achieved. He had fever and abdominal pain on postoperative day (POD) 2. Computed tomography (CT) revealed the intra-abdominal free air, leading to a diagnosis of delayed perforation after ESD. Vital signs were stable, the perforation was considered minor, and endoscopic closure was attempted. The colonoscopy under fluoroscopy showed no perforation in the ulcer and no leakage of the contrast medium. He was managed conservatively with antibiotics and nothing per os. Symptoms improved; however, a follow-up CT on POD 13 revealed a 65-mm pelvic abscess, and endoscopic ultrasound (EUS)-guided drainage was successfully performed. The follow-up CT on POD 23 showed the reduction of abscess, and the drainage tubes were removed. Emergent surgical treatment is crucial in delayed perforation because it has a poor prognosis, and reports of conservative therapy for colonic ESD with delayed perforation are few. The present case was managed with antibiotics and EUS-guided drainage. Thus, EUS-guided drainage can be a treatment option for delayed perforation after colorectal ESD, if the abscess is localized.
Checkpoint-Inhibitoren: Wie das Mikrobiom den Behandlungserfolg beeinflusst
Authors: Couto Irving Susana , Hug Adele
Published: March 2023

Host immunity plays a central role in the regulation of anti-tumour responses during checkpoint inhibitor therapy (CIT). The mechanisms involved in long lasting remission remain unclear. Animal studies have revealed that the microbiome influences the host immune response. This is supported by human studies linking a higher microbial richness and diversity with enhanced responses to CIT. This review focuses on the role of diet, the microbiome and the microbiome-derived metabolome in enhancing responses to current CIT in solid tissue cancers. The Western diet has been associated with dysbiosis, inflammation and numerous metabolic disorders. There is preliminary evidence that lifestyle factors including a high fibre diet are associated with improved responses to CIT via a potential effect on the microbiota. The mechanisms through which the microbiota may regulate long-term immunotherapy responses have yet to be determined, although bacterial-metabolites including short chain fatty acids (SCFAs) are recognized to have an impact on T cell differentiation, and may affect T effector/regulatory T cell balance. SCFAs were also shown to enhance the memory potential of activated CD8 T cells. Many therapeutic approaches including dietary manipulation and fecal transplantation are currently being explored in order to enhance immunotherapy responses. The microbiome-derived metabolome may be one means through which bacterial metabolic products can be monitored from the start of treatment and could be used to identify patients at risk of poor immunotherapy responses. The current review will discuss recent advances and bring together literature from related fields in nutrition, oncology and immunology to discuss possible means of modulating immunity to improve responses to current CIT.
Clinical Outcomes in Patients on Hemodialysis with Congestive Heart Failure
Authors: Zhao Xinju , Gan Liangying , Niu Qingyu , Hou Fan Fan , Liang Xinlin , Chen Xiaonong , Chen Yuqing , Zhao Junhui , McCullough Keith , Ni Zhaohui , Zuo Li
Published: March 2023

Introduction: Congestive heart failure (CHF) is one of the common complications in patients with end-stage kidney disease. In the general population, CHF increases the risk of the death. However, there is no well-designed relevant study in the Chinese hemodialysis (HD) population addressing the risks associated with CHF. The aim of this study was to explore the impact of CHF on clinical outcomes in HD patients. Methods: Data from a prospective cohort study, the China Dialysis Outcomes and Practice Patterns Study (DOPPS) 5 (2012–2015), were analyzed. Demographic data, comorbidities, lab data, and death records were extracted. CHF was defined by the diagnosis records upon study inclusion. Our primary outcome was all-cause and cardiovascular (CV) mortality; secondary outcomes were all-cause and cause-specific hospitalization risk. Associations between CHF and outcomes were evaluated using Cox regression models. Stepwise multivariate logistic regression was used to identify the related risk factors, and subgroup analyses were carried out. Results: Of 1,411 patients without missing CHF history information, 24.1% (340) had CHF diagnosis at enrollment. The overall mortality rates were 21.8% versus 12.0% (p < 0.001) in patients with and without CHF during follow-up, respectively. CHF was associated with higher all-cause mortality (adjusted HR: 1.72, 95% confidence interval [CI]: 1.17–2.53, p = 0.006), and the association with CV death was of similar magnitude (HR: 1.60, 95% CI: 0.91–2.81, p = 0.105). CHF patients had more episodes of hospitalization due to heart failure (HR: 2.93, 95% CI: 1.49–5.76, p < 0.01). However, compared with patients without CHF, the all-cause hospitalization risk was not much higher in CHF patients (HR: 1.09, 95% CI: 0.90–1.33, p = 0.39). Subgroup analysis found that the effect of CHF on all-cause mortality was stronger for male patients, patients with residual renal function, the elderly (≥60 years of age), patients with arteriovenous fistulae vascular accesses, nondiabetic patients, low-flux dialyzer users, and inadequately dialyzed patients (standardized Kt/V <2). Conclusion: In HD patients, CHF was found to be associated with a higher risk of all-cause mortality and cause-specific hospitalization risk. Further research is needed to identify opportunities to improve care for HD patients combined with CHF.
Optimization of bakery production by using branch and bound approach
Authors: Rahimullaily Rahimullaily , Darwas Rahmadini , Purwasih Ratih
Published: March 2023

Mommy Ai Kitchen is one the businesses specializing in the bakery business, producing cupcakes, birthday cakes, brownies, and donuts. However, it does not optimally determine each bakery’s production quantity, so it offers fewer profits and becomes a problem. This research aims to find the optimal production quantity so that this business maximizes profits. The method used was integer programming using the branch and bound approach, which counts the decision variable value using the simplex method. This research was based on the number of raw materials on hand-wheat flour, sugar, eggs, modal, and the profits of each bakery. Based on the analysis of the branch and bound approach, it was known that the maximum profit value was IDR 253,200, with eight alternative options for the bakeries that were produced. One of them was Mommy Ai Kitchen, which could produce three cupcakes, five birthday cakes, one brownie, and nine donuts to get that maximum profit. Meanwhile, Mommy Ai Kitchen’s estimation could produce one cupcake, one brownie, and six donuts using available materials with a profit of IDR 78,800. As a result, the profit difference before and after integer programming was IDR 174,400.
The effect of segmentation on the performance of machine learning methods on the morphological classification of Friesien Holstein dairy cows
Authors: Siregar Amril Mutoi , Purwanto Yohanes Aris , Wijaya Sony Hartono , Nahrowi Nahrowi
Published: March 2023

Many classification algorithms are in the form of image pattern recognition; the approach to the complexity of the problem should be a feature of feasibility for representing images. The morphology of dairy cows greatly affects their health and milk production. The paper will apply several classification methods based on the morphology of Holstein Friesian dairy cows. To improve the accuracy of the model used, the segmentation process is the right step. In this paper, we compare several machine learning algorithms to get optimal accuracy. The algorithm used a support vector machine (SVM), artificial neural networks, random forests and logistic regression. Segmentation methods used are mask region-based convolutional neural network (R-CNN) and Canny; optimal accuracy is expected to create intelligent applications. The success of the method is measured with accuracy, precision, recall, and F1 Score, as well as testing by conducting a training-testing ratio of 90:10 and 80:20. This study discovered an artificial neural network optimal model with Canny with an accuracy of 82.50%, precision of 87.00%, recall of 79.00%, F1-score of 81.62%, and testing ratio of 90:10. While the models with the highest 80:20 ratio achieved 84.39% accuracy, 88.46% precision, 80.47%, and 83.00% F1-score with mask R-CNN with logistic regression.
Exploring application portfolio management in Indonesia: a case study of the Indonesia agency for the assessment and application of technology
Authors: Kusumarani Riri , Pramesti Raden Putri Ayu
Published: March 2023

Due to rapid information and communication technology (ICT) growth, government agencies must manage more digital apps to support public service operations and administration. In Indonesia, at least 400,000 applications have been received by various ministries and government agencies. This amount will hurt the ICT budget’s investment and waste if no approach is employed. Problems can be solved with application portfolio management (APM). Indonesian government agencies’ AMP implementation is unclear. APM is applied at the government research institute agency for the assessment and application of technology (BPPT) in this study. BPPT was chosen due to APM’s lack of ICT investment management. This research examined 41 submissions from the 2019 digital transformation initiative. APM selected two mapping models. The outcome indicates how APM may offer ICT strategies for current applications to government entities. This analysis mapped existing applications into two models: McFarlan’s strategic grid and gartner’s TIME model. Mapping findings from these two models-technical health evaluations and regulatory compliance-may be used for application sustainability suggestions. 11 treatments were advised for maintenance and investment, while 4 applications were recommended for removal. This research helps us understand how the Indonesian government institute maintains its application portfolio and how APM might be a valuable method for application management.
Sex Differences in Oral Anticoagulation Therapy in Patients Hospitalized With Atrial Fibrillation: A Nationwide Cohort Study
Authors: Lee Kuan Ken , Doudesis Dimitrios , Bing Rong , Astengo Federica , Perez Jesus R. , Anand Atul , McIntyre Shauna , Bloor Nicholas , Sandler Belinda , Lister Steven , Pollock Kevin G. , Qureshi Ayesha C. , McAllister David A. , Shah Anoop S. V. , Mills Nicholas L.
Published: March 2023

Background

Important disparities in the treatment and outcomes of women and men with atrial fibrillation (AF) are well recognized. Whether introduction of direct oral anticoagulants has reduced disparities in treatment is uncertain.

Methods and Results

All patients who had an incident hospitalization from 2010 to 2019 with nonvalvular AF in Scotland were included in the present cohort study. Community drug dispensing data were used to determine prescribed oral anticoagulation therapy and comorbidity status. Logistic regression modeling was used to evaluate patient factors associated with treatment with vitamin K antagonists and direct oral anticoagulants. A total of 172 989 patients (48% women [82 833 of 172 989]) had an incident hospitalization with nonvalvular AF in Scotland between 2010 and 2019. By 2019, factor Xa inhibitors accounted for 83.6% of all oral anticoagulants prescribed, while treatment with vitamin K antagonists and direct thrombin inhibitors declined to 15.9% and 0.6%, respectively. Women were less likely to be prescribed any oral anticoagulation therapy compared with men (adjusted odds ratio [aOR], 0.68 [95% CI, 0.67–0.70]). This disparity was mainly attributed to vitamin K antagonists (aOR, 0.68 [95% CI, 0.66–0.70]), while there was less disparity in the use of factor Xa inhibitors between women and men (aOR, 0.92 [95% CI, 0.90–0.95]).

Conclusions

Women with nonvalvular AF were significantly less likely to be prescribed vitamin K antagonists compared with men. Most patients admitted to the hospital in Scotland with incident nonvalvular AF are now treated with factor Xa inhibitors and this is associated with fewer treatment disparities between women and men.
Remote Diffusion-Weighted Imaging Lesions and Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis
Authors: Posener Sacha , Hmeydia Ghazi , Benzakoun Joseph , Oppenheim Catherine , Baron Jean-Claude , Turc Guillaume
Published: March 2023

Background:

Remote diffusion-weighted imaging lesions (RDWILs) in the context of spontaneous intracerebral hemorrhage (ICH) are associated with an increased risk of recurrent stroke, worse functional outcome, and death. To update current knowledge on RDWILs, we conducted a systematic review and meta-analysis of the prevalence, associated factors and presumed causes of RDWILs.

Methods:

We searched Pubmed, Embase, and Cochrane up to June 2022 for studies reporting RDWILs in adults with symptomatic ICH of no-identified-cause, assessed by magnetic resonance imaging, and analyzed associations between baseline variables and RDWILs in random-effects meta-analyses.

Results:

Eighteen observational studies (7 prospective), reporting 5211 patients were included, of whom 1386 had ≥1 RDWIL (pooled prevalence: 23.5% [19.0–28.6]). RDWIL presence was associated with neuroimaging features of microangiopathy, atrial fibrillation (odds ratio, 3.67 [1.80–7.49]), clinical severity (mean difference in National Institutes of Health Stroke Scale score, 1.58 points [0.50–2.66]), elevated blood pressure (mean difference, 14.02 mmHg [9.44–18.60]), ICH volume (mean difference, 2.78 mL [0.97–4.60]), and subarachnoid (odds ratio, 1.80 [1.00–3.24]) or intraventricular (odds ratio, 1.53 [1.28–1.83]) hemorrhage. RDWIL presence was associated with poor 3-month functional outcome (odds ratio, 1.95 [1.48–2.57]).

Conclusions:

RDWILs are detected in approximately 1-in-4 patients with acute ICH. Our results suggest that most RDWILs result from disruption of cerebral small vessel disease by ICH-related precipitating factors such as elevated intracranial pressure and cerebral autoregulation impairment. Their presence is associated with worse initial presentation and outcome. However, given the mostly cross-sectional designs and heterogeneity in study quality, further studies are needed to investigate whether specific ICH treatment strategies may reduce the incidence of RDWILs and in turn improve outcome and reduce stroke recurrence.
Early Stroke and Mortality After Percutaneous Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation
Authors: Kogan Edward V. , Sciria Christopher T. , Liu Christopher F. , Wong S. Chiu , Bergman Geoffrey , Ip James E. , Thomas George , Markowitz Steven M. , Lerman Bruce B. , Kim Luke K. , Cheung Jim W.
Published: March 2023

Background:

Percutaneous endocardial left atrial appendage occlusion (LAAO) is an alternative therapy for stroke prevention in patients with atrial fibrillation who are poor candidates for oral anticoagulants. Oral anticoagulation is generally discontinued 45 days following successful LAAO. Real-world data on early stroke and mortality following LAAO are lacking.

Methods:

Using
International Classification of Diseases, Tenth Revision
, Clinical-Modification codes, we performed a retrospective observational registry analysis to examine the rates and predictors of stroke, mortality, and procedural complications during index hospitalization and 90-day readmission among 42 114 admissions in the Nationwide Readmissions Database for LAAO between 2016 and 2019. Early stroke and mortality were defined as events occurring during index admission or 90-day readmission. Data on timing of early strokes post-LAAO were collected. Multivariable logistic regression modeling was used to ascertain predictors of early stroke and major adverse events.

Results:

LAAO was associated with low rates of early stroke (0.63%), early mortality (0.53%), and procedural complications (2.59%). Among patients who had readmissions with strokes after LAAO, the median time from implant to readmission was 35 days (interquartile range, 9–57 days); 67% of readmissions with strokes occurred <45 days postimplant. Between 2016 and 2019, the rates of early stroke after LAAO significantly decreased (0.64% versus 0.46%
P
-for-trend <0.001), while early mortality and major adverse event rates were unchanged. Peripheral vascular disease and a history of prior stroke were independently associated with early stroke after LAAO. Early post-LAAO stroke rates were similar between low, medium, and high LAAO volume tertile centers.

Conclusions:

In this contemporary real-world analysis, the early stroke rate after LAAO was low, with the majority occurring within 45 days of device implantation. Despite an increase in LAAO procedures between 2016 and 2019, there with a significant decline in early strokes after LAAO during that period.
Validation of Brain Injury Guidelines in the Elderly Trauma Patient Presenting at a Level Two Trauma Center
Authors: Wasfie Tarik , Korbitz Holland , Odowd Brendan , Hille Jennifer Lynn , Hella Jennifer , Barber Kimberly , Yapchai Raquel , Brian Shapiro
Published: March 2023

Retrospective analysis, validating the brain injury guideline (BIG) in the management of traumatic head injury in our level II trauma center after implementation of the protocol, and compare the outcomes to those seen before the protocol, of 542 patients seen in the Emergency Department (ED), with head injury between 2017 and 2021 was completed. Those patients were divided into two groups: Group 1 (pre BIG protocol implementation) and Group 2 (post BIG protocol implementation). Data included age, race, length of stay (hospital and ICU), comorbid conditions, anticoagulant therapy, surgical intervention, GCS, ISS, findings of head CT and any subsequent progression, mortality, and readmission within one month. Student’s t-test and Chi-square test were used for statistical analysis. There were 314 patients in group 1 and 228 patients in group 2. Mean age of group 2 was significantly higher than group 1 (67 vs 59 years, p=0.0001), however their gender was similar. Data available on 526 patients were classified as BIG 1=122, BIG 2=73, and BIG 3=331 patients. Post-implementation group were older (70 vs 44 years, P=0.0001) with more females (67% vs 45%, P=0.05) and had significantly more than 4 comorbid conditions (29% vs 8%, P=0.004), with the majority presented with a size of 4 mm or less of acute subdural or subarachnoid hematoma. No patient in either group had progression of their neurological examination, neurosurgical intervention, or readmission.. Elderly trauma patients may benefit from implementation of BIG criteria protocol, thus reducing cost of patient care, however a larger sample size is needed.
Simulation in Surgical Resident Education: A Porcine Hemostasis and Laparoscopic Model
Authors: Cambronero Gabriel E. , Sanin Gloria D. , Patterson James W. , Galli Lucas D. , Garcia Chris , Bosley Maggie E. , Powell Myron S. , Ashburn Jean H. , Jordan James E.
Published: March 2023

The steep learning curve associated with learning laparoscopic techniques and limited training opportunities represents a challenge to general surgery resident training. The objective of this study was to use a live porcine model to improve surgical training in laparoscopic technique and management of bleeding. Nineteen general surgery residents (ranging from PGY 3 to 5) completed the porcine simulation and completed pre-lab and post-lab questionnaires. The institution’s industry partner served as sponsors and educators on hemostatic agents and energy devices. Residents had a significant increase in confidence with laparoscopic techniques and the management of hemostasis ( P = .01 and P = .008, respectively). Residents agreed and then strongly agreed that a porcine model was suitable to simulate laparoscopic and hemostatic techniques, but there was no significant change between pre- and post-lab opinions. This study demonstrates that a porcine lab is an effective model for surgical resident education and increases resident confidence.
Atraumatic Acute Paraspinal Compartment Syndrome in a Patient With McArdle’s Disease
Authors: Pollock Aaron B. , Huggins John C. , Harrell Kevin N.
Published: March 2023

A 60-year-old male presented to the emergency room with complaints of back pain overlying the left lumbar area and ipsilateral thigh numbness. The left erector spinae musculature was rigid, tense, and painful to palpation. An elevated serum creatine kinase was identified, and a computed tomography scan showed evidence of left paraspinal musculature congestion. Past medical/surgical history was significant for McArdle’s disease and bilateral forearm fasciotomies. The patient underwent lumbosacral fasciotomy with no obvious myonecrosis. The patient was discharged home after skin closure and has since been seen in clinic with no residual pain or change in baseline functional status. This case may represent the first reported atraumatic exertional lumbar compartment syndrome in a patient with McArdle’s disease. Prompt operative intervention was effective in this case of acute atraumatic paraspinal compartment syndrome and resulted in an excellent functional outcome.
Gastrointestinal Discontinuity After Emergency Laparotomy
Authors: Liao Peter , Hoffman Kyle , Broussard Andrew , Fuhrman George
Published: March 2023

During laparotomy, patients requiring intestinal resection may be temporarily left in gastrointestinal discontinuity (GID). We performed this study to determine predictors of futility for patients initially left in GID after emergency bowel resection. We divided the patients into 3 groups: never restored continuity and died (group 1), restored continuity and died (group 2), and restored continuity and survived (group 3). We compared the 3 groups for differences in demographics, acuity at presentation, hospital course, laboratory data, comorbidities, and outcomes. From a total of 120 patients, 58 patients died and 62 survived. We identified 31 patients in group 1, 27 patients in group 2, and 62 patients in group 3. On multivariate logistic regression, only lactate ( P = .002) and use of vasopressors ( P = .014) remained significant to predict survival. The results of this study can be used to identify futile situations which can direct end-of-life decisions.
The “Turn Once Again Toward Practice-Based Teacher Education” Revisited
Authors: Zeichner Ken
Published: March 2023

This paper provides an analysis of how work on practice-based teacher education has evolved and remained the same since 2012.
The pathway to the natural gas industry: Financial development, coal consumption, and carbon dioxide emissions in P.R. China
Authors: Tong Teng , Ortiz Jaime , Wang Haibo
Published: March 2023

This paper revisits the causal links between financial development, coal consumption, and CO2 emissions in P.R. China over the 1977–2017 period to validate the development of its natural gas industry. It uses a Bootstrap ARDL bound test with structural breaks to establish stationarity, short- and long-run dynamics, and causality of the series. The results show there are no long-run relationships among these three variables, but a Granger causality test does indicate the presence of both a two-way Granger causality between coal consumption and CO2 emissions, and a one-way Granger causality running from financial development to both coal consumption and CO2 emissions. These results have important policy implications for the Chinese government's efforts to meet its commitment at the 75th UN General Assembly to achieve carbon neutrality. In that context, the promotion of its natural gas industry, including carbon pricing mechanisms and taxation schemes while enacting environmentally friendly energy abatement policies become a must.
Leveraging paradigms to foster theoretical contributions in information systems research
Authors: Marchildon Philippe , Hadaya Pierre
Published: March 2023

Despite all our theorizing efforts and the importance that we and our major information systems (IS) journals ascribe to theory development, making theoretical contributions to our field remains challenging. Recognizing that we cannot develop better theories without improving how we theorize, our field is now engaged in an in-depth discussion of the theorizing process. This manuscript contributes to this discussion by exposing why and how leveraging paradigms when theorizing can foster theoretical contributions within our field. Its premise is that we need to stop working within the confines of a limited set of well-entrenched paradigms and move beyond what is known as true and correct to come up with improvements that significantly alter the way we come to rationalize, explain, and master our world. Anchored on this premise, this manuscript begins by discussing the origin, role, and features of paradigms as well as explaining that they are of three different but interrelated forms (i.e., metaphysical, sociological, and artefactual). The manuscript then adds to this understanding of paradigms by detailing the unique relationships that tie paradigms of each form to theory and explaining why taking advantage of these unique bonds when theorizing may help us make theoretical contributions. Lastly, to foster theoretical contributions within our field, this manuscript proposes a set of guidelines to help us leverage paradigms of the different forms when theorizing.
Short-Term and Long-Term Impacts of Financial Sextortion on Victim’s Mental Well-Being
Authors: O’Malley Roberta Liggett
Published: March 2023

Sextortion occurs when an individual threatens to distribute a victim’s intimate images, videos, or information unless they comply with the perpetrator’s demands. In financially motivated sextortion, these demands include payment of a ransom. Despite global increases in financially motivated sextortion victimization, there is limited research on the psychological impacts of this type of victimization. Leveraging 332 threads (3,276 posts) from a popular sextortion support forum, the purpose of this research was to use inductive qualitative methods to understand how financially motivated sextortion impacts victims’ mental well-being, their online engagement, and how they process and deal with these impacts. The results illustrate four main concepts: short-term impacts, long-term impacts, coping strategies, and getting better over time. Short-term impacts included worry, stress, anxiety, self-blame, and somatic symptoms of stress. Long-term impacts included enduring episodes of anxiety. Some sources of coping reported by forum users were to confide in a trusted friend, stay offline, or seek professional mental health care. Despite these impacts, many forum members expressed a sense that their anxiety and distress “get better overtime,” a concept that was assisted through active coping strategies.