bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review on Froth Washing in Flotation
Authors: Jera Tawona Martin , Bhondayi Clayton
Published: November 2022

In the attempt to process lower-grade ores, mineral flotation has taken centre stage as the preferred recovery route. However, in many instances, the froth product does not have a high grade due to the entrainment of gangue minerals. Industry has solved this challenge by introducing froth washing mechanisms. Clean wash water is introduced into or on top of the froth to reduce the amount of entrained gangue in the final concentrate. This article reviews froth-washing systems in detail and highlights the advantages and disadvantages of each wash-water delivery mechanism. Comments on industrial uptake are provided. The indications are that froth washing improves the grade of the concentrate and influences froth stability and mobility. Other researchers have reported an improvement in recovery—especially of coarse particles—with wash water being added, while others have reported a reduction in recovery, especially with composite particles. Froth washing is generally applied in mechanical flotation cells by washing at the lip. In column flotation cells and Jameson cells, wash water is added to the entire froth surface. The literature also indicates that the wash-water rate, wash-water quality, type of wash-water delivery/ distribution mechanism and the area covered by wash water are critical parameters that dictate the efficacy of the washing system. Further research is necessary on the impact of wash-water quality on the froth phase sub-processes including froth rheology.
A Novel Enhanced Total Gradient (ETG) for Interpretation of Magnetic Data
Authors: Prasad Korimilli Naga Durga , Pham Luan Thanh , Singh Anand P. , Eldosouky Ahmed M. , Abdelrahman Kamal , Fnais Mohammed S. , Gómez-Ortiz David
Published: November 2022

Edge detection techniques identify the horizontal extents of the underground geological bodies and work well in association with magnetic as well as seismic data. Even though the detected edges might not be a lithological contact, they offer first-hand information regarding various rocks that ultimately offers an extra argument for existing tectonics. Most of the edge enhancement techniques depend either on the horizontal gradient or total gradient of the potential fields. As of now, no single edge detection filter performance is best in all conditions. The study proposes a novel edge detection filter called “ETG-Enhanced Total Gradient” that combines the derivatives of the analytic signal (AS) (in the third dimension). The maximum amplitude of the AS is less dependent of the direction of magnetization and is critical in mapping the borders of the buried magnetic sources beneath the Earth. As the ETG filter is based on the total gradient of the field, there is no need to apply reduction to the pole process on the magnetic data. One limitation of the method is that the filter is unable to perform better at the corners where the other conventional methods miserably failed. The filter’s behavior is examined and validated using 2D and 3D synthetic magnetic data. The reliability of the ETG filter is examined by applying it to the magnetic data of the Seattle uplift region, USA. A new structural map of the region is generated by using the proposed ETG filter. The observed peak response of the ETG filter is well correlated with major tectonic features such as the Seattle Fault Zone (SFZ), Hood Canal Fault (HCF), and Dewatto Fault (DF).
Limoniastrum monopetalum–Mediated Nanoparticles and Biomedicines: In Silico Study and Molecular Prediction of Biomolecules
Authors: Mohammed Afrah E. , Alghamdi Sahar S. , Alharbi Nada K. , Alshehri Fatma , Suliman Rasha Saad , Al-Dhabaan Fahad , Alharbi Maha
Published: November 2022

An in silico approach applying computer-simulated models helps enhance biomedicines by sightseeing the pharmacology of potential therapeutics. Currently, an in silico study combined with in vitro assays investigated the antimicrobial ability of Limoniastrum monopetalum and silver nanoparticles (AgNPs) fabricated by its aid. AgNPs mediated by L. monopetalum were characterized using FTIR, TEM, SEM, and DLS. L. monopetalum metabolites were detected by QTOF–LCMS and assessed using an in silico study for pharmacological properties. The antibacterial ability of an L. monopetalum extract and AgNPs was investigated. PASS Online predictions and the swissADME web server were used for antibacterial activity and potential molecular target metabolites, respectively. Spherical AgNPs with a 68.79 nm average size diameter were obtained. Twelve biomolecules (ferulic acid, trihydroxy-octadecenoic acid, catechin, pinoresinol, gallic acid, myricetin, 6-hydroxyluteolin, 6,7-dihydroxy-5-methoxy 7-O-β-d-glucopyranoside, methyl gallate, isorhamnetin, chlorogenic acid, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-β-l-mannopyranosyl)-β-d-glucopyranoside) were identified. The L. monopetalum extract and AgNPs displayed antibacterial effects. The computational study suggested that L. Monopetalum metabolites could hold promising antibacterial activity with minimal toxicity and an acceptable pharmaceutical profile. The in silico approach indicated that metabolites 8 and 12 have the highest antibacterial activity, and swissADME web server results suggested the CA II enzyme as a potential molecular target for both metabolites. Novel therapeutic agents could be discovered using in silico molecular target prediction combined with in vitro studies. Among L. Monopetalum metabolites, metabolite 12 could serve as a starting point for potential antibacterial treatment for several human bacterial infections.
HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells
Authors: Suk Fat-Moon , Wu Chien-Ying , Chiu Wan-Chun , Chien Chia-Ying , Chen Tzu-Lang , Liao Yi-Jen
Published: November 2022

Primary liver cancer is the fifth leading death of cancers in men, and hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancer cases. Sorafenib is a first-line drug for advanced-stage HCC patients. Sorafenib is a multi-target kinase inhibitor that blocks tumor cell proliferation and angiogenesis. Despite sorafenib treatment extending survival, some patients experience side effects, and sorafenib resistance does occur. 3-Hydroxymethyl glutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme for ketogenesis, which synthesizes the ketone bodies, β-hydroxybutyrate (β-HB) and acetoacetate (AcAc). β-HB is the most abundant ketone body which is present in a 4:1 ratio compared to AcAc. Recently, ketone body treatment was found to have therapeutic effects against many cancers by causing metabolic alternations and cancer cell apoptosis. Our previous publication showed that HMGCS2 downregulation-mediated ketone body reduction promoted HCC clinicopathological progression through regulating c-Myc/cyclin D1 and caspase-dependent signaling. However, whether HMGCS2-regulated ketone body production alters the sensitivity of human HCC to sorafenib treatment remains unclear. In this study, we showed that HMGCS2 downregulation enhanced the proliferative ability and attenuated the cytotoxic effects of sorafenib by activating expressions of phosphorylated (p)-extracellular signal-regulated kinase (ERK), p-P38, and p-AKT. In contrast, HMGCS2 overexpression decreased cell proliferation and enhanced the cytotoxic effects of sorafenib in HCC cells by inhibiting ERK activation. Furthermore, we showed that knockdown HMGCS2 exhibited the potential migratory ability, as well as decreasing zonula occludens protein (ZO)-1 and increasing c-Myc expression in both sorafenib-treated Huh7 and HepG2 cells. Although HMGCS2 overexpression did not alter the migratory effect, expressions of ZO-1, c-Myc, and N-cadherin decreased in sorafenib-treated HMGCS2-overexpressing HCC cells. Finally, we investigated whether ketone treatment influences sorafenib sensitivity. We showed that β-HB pretreatment decreased cell proliferation and enhanced antiproliferative effect of sorafenib in both Huh7 and HepG2 cells. In conclusion, this study defined the impacts of HMGCS2 expression and ketone body treatment on influencing the sorafenib sensitivity of liver cancer cells.
Morphology-Controlled Synthesis of V1.11S2 for Electrocatalytic Hydrogen Evolution Reaction in Acid Media
Authors: Chen Qiuyue , Tian Siqi , Liu Xiaonan , An Xuguang , Zhang Jingxian , Xu Longhan , Yao Weitang , Kong Qingquan
Published: November 2022

High-performance low-cost catalysts are in high demand for the hydrogen evolution reaction (HER). In the present study, we reported that V1.11S2 materials with flower-like, flake-like, and porous morphologies were successfully synthesized by hydrothermal synthesis and subsequent calcination. The effects of morphology on hydrogen evolution performance were studied. Results show that flower-like V1.11S2 exhibits the best electrocatalytic activity for HER, achieving both high activity and preferable stability in 0.5 M H2SO4 solution. The main reason can be ascribed to the abundance of catalytically active sites and low charge transfer resistance.
Natural Deep Eutectic Solvent-Assisted Extraction, Structural Characterization, and Immunomodulatory Activity of Polysaccharides from Paecilomyces hepiali
Authors: Wang Yanbin , Xu Feijia , Cheng Junwen , Wu Xueqian , Xu Juan , Li Chunru , Li Weiqi , Xie Na , Wang Yuqin , He Liang
Published: November 2022

Polysaccharides, which can be affected by different preparations, play a crucial role in the biological function of Paecilomyces hepiali (PHPS) as a health food. To explore high-valued polysaccharides and reduce the negative influence of human involvement, a green tailorable deep eutectic solvent (DES) was applied to optimize the extraction of polysaccharides (PHPS-D), followed by the evaluation of the structural properties and immunomodulation by comparison with the hot-water method (PHPS-W). The results indicated that the best system for PHPS-D was a type of carboxylic acid-based DES consisting of choline chloride and succinic acid in the molar ratio of 1:3, with a 30% water content. The optimal condition was as follows: liquid–solid ratio of 50 mL/g, extraction temperature of 85 °C, and extraction time of 1.7 h. The actual PHPS-D yield was 12.78 ± 0.17%, which was obviously higher than that of PHPS-W. The structural characteristics suggested that PHPS-D contained more uronic acid (22.34 ± 1.38%) and glucose (40.3 ± 0.5%), with a higher molecular weight (3.26 × 105 g/mol) and longer radius of gyration (78.2 ± 3.6 nm), as well as extended chain conformation, compared with PHPS-W, and these results were confirmed by AFM and SEM. Immunomodulatory assays suggested that PHPS-D showed better performance than PHPS-W regarding pinocytic activity and the secretion of NO and pro-inflammatory cytokines (IL-6, TNF-α and IL-1β) by activating the corresponding mRNA expression in RAW264.7 cells. This study showed that carboxylic acid-based DES could be a promising tailorable green system for acidic polysaccharide preparation and the valorization of P. hepiali in functional foods.
Preparation of Nitrogen and Sulfur Co-Doped Fluorescent Carbon Dots from Cellulose Nanocrystals as a Sensor for the Detection of Rutin
Authors: Zhang Tao , Ji Qingxue , Song Jiayi , Li Haiming , Wang Xing , Shi Haiqiang , Niu Meihong , Chu Tingting , Zhang Fengshan , Guo Yanzhu
Published: November 2022

The poor water solubility, large particle size, and low accessibility of cellulose, the most abundant bioresource, have restricted its generalization to carbon dots (CDs). Herein, nitrogen and sulfur co-doped fluorescent carbon dots (N, S-CDs) were hydrothermally synthesized using cellulose nanocrystals (CNC) as a carbon precursor, exhibiting a small particle size and excellent aqueous dispersion. Thiourea was selected as a nitrogen and sulfur dopant to introduce abundant fluorescent functional groups into N, S-CDs. The resulting N, S-CDs exhibited nanoscale size (6.2 nm), abundant functional groups, bright blue fluorescence, high quantum yield (QY = 27.4%), and high overall yield (16.2%). The excellent optical properties of N, S-CDs endowed it to potentially display a highly sensitive fluorescence “turn off” response to rutin. The fluorescence response for rutin allowed a wide linear range of 0–40 mg·L−1, with a limit of detection (LOD) of 0.02 μM, which revealed the potential of N, S-CDs as a rapid and simple sensing platform for rutin detection. In addition, the sustainable and large-scale production of the N, S-CDs in this study paves the way for the successful high-value utilization of cellulose.
The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
Authors: Rahmani Arshad Husain , Almatroudi Ahmad , Khan Amjad Ali , Babiker Ali Yousif , Alanezi Malak , Allemailem Khaled S.
Published: November 2022

The roles of medicinal plants or their purified bioactive compounds have attracted attention in the field of health sciences due to their low toxicity and minimal side effects. Baicalein is an active polyphenolic compound, isolated from Scutellaria baicalensis, and plays a significant role in the management of different diseases. Epidemiologic studies have proven that there is an inverse association between baicalein consumption and disease severity. Baicalein is known to display anticancer activity through the inhibition of inflammation and cell proliferation. Additionally, the anticancer potential of baicalein is chiefly mediated through the modulation of various cell-signaling pathways, such as the induction of apoptosis, autophagy, cell cycle arrest, inhibition of angiogenesis, signal transducer and activator of transcription 3, and PI3K/Akt pathways, as well as the regulation of other molecular targets. Therefore, the current review aimed to explore the role of baicalein in different types of cancer along with mechanisms of action. Besides this, the synergistic effects with other anti-cancerous drugs and the nano-formulation based delivery of baicalein have also been discussed.
Synthesis of Tetrasubstituted Phosphorus Analogs of Aspartic Acid as Antiproliferative Agents
Authors: del Corte Xabier , Maestro Aitor , López-Francés Adrián , Palacios Francisco , Vicario Javier
Published: November 2022

An efficient general method for the synthesis of a wide family of α-aminophosphonate analogs of aspartic acid bearing tetrasubstituted carbons is reported through an aza-Reformatsky reaction of α-iminophosphonates, generated from α-aminophosphonates, in an umpolung process. In addition, the α-aminophosphonate substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV3 (human ovarian carcinoma). In view of the possibilities in the diversity of the substituents that offer the synthetic methodology, an extensive profile structure–activity is presented, measuring IC50 values up to 0.34 µM in the A549 and 9.8 µM in SKOV3 cell lines.
Recent Development of Tunable Optical Devices Based on Liquid
Authors: Wu Qi , Zhang Hongxia , Jia Dagong , Liu Tiegen
Published: November 2022

Liquid opens up a new stage of device tunability and gradually replaced solid-state devices and mechanical tuning. It optimizes the control method and improves the dynamic range of many optical devices, exhibiting several attractive features, such as rapid prototyping, miniaturization, easy integration and low power consumption. The advantage makes optical devices widely used in imaging, optical control, telecommunications, autopilot and lab-on-a-chip. Here, we review the tunable liquid devices, including isotropic liquid and anisotropic liquid crystal devices. Due to the unique characteristics of the two types of liquids, the tuning principles and tuning methods are distinguished and demonstrated in detail firstly and then some recent progress in this field, covering the adaptive lens, beam controller, beam filter, bending waveguide, iris, resonator and display devices. Finally, the limitations and future perspectives of the current liquid devices are discussed.
Role of AuNPs in Active Food Packaging Improvement: A Review
Authors: Ahari Hamed , Fakhrabadipour Mostafa , Paidari Saeed , Goksen Gulden , Xu Baojun
Published: November 2022

There is a worldwide concern about food loss due to reduced shelf life among food science researchers. Hence, it seems that any techniques contributing to improved food packaging are most welcome in the food sector. It has been demonstrated that the administration of nanotechnology-based techniques such as metal-based nanoparticles can fade away the unresolved obstacles in shortened shelf life and environmental concerns. Along with substantial signs of progress in nanoscience, there is a great interest in the usage of green synthesis-based methods for gold nanoparticles as the most advantageous metals, when compared to conventional chemistry-based methods. Interestingly, those aforementioned methods have significant potential to simplify targeted administration of gold nanoparticles due to a large surface-volume ratio, and diminished biohazards, aimed at increasing stability, and induction of anti-microbial or antioxidant properties. However, it is necessary to consider the hazards of gold nanoparticles including migration for food packaging purposes.
Preparation of Low Volatile Organic Compounds Silver Paste Containing Ternary Conductive Fillers and Optimization of Their Performances
Authors: Cheng Youliang , Zhang Jin , Fang Changqing , Qiu Wenke , Chen Hao , Liu Haonan , Wei Ying
Published: November 2022

Conductive silver paste is a key material in the fields of printed circuits and printed electronic devices. However, the preparation of conductive silver paste with low-cost and volatile organic compounds (VOCs) is still a challenge. In this work, conductive silver pastes with excellent comprehensive performances were developed by using water-borne polyurethane (WPU) as the bonding phase and using the ternary mixture of Ag microflakes (Ag MFs), Ag nanowires (Ag NWs), and Ag nanoparticles (Ag NPs) as the conductive phase. WPU endowed conductive silver pastes with the adhesion along with releasing a few VOCs during the curing. Results showed that a small amount of Ag NPs or Ag NWs dramatically enhanced the electrical conductivity of silver paste paint film filled only with Ag MFs. The electrical resistivity for optimal ternary mixture conductive silver paste was 0.2 × 10−3 Ω∙cm, and the conductive phase was composed of 20.0 wt% Ag MFs, 7.5 wt% Ag NWs, and 2.5 wt% Ag NPs. Meanwhile, the adhesive strength and hardness of silver paste paint film were effectively improved by increasing the curing temperature. The optimal overall performance of the conductive silver pastes was achieved at the curing temperature of 160 °C. Therefore, this work can provide a new route for preparing conductive silver pastes with high performances.
The Effect of Different Growth Stages of Black Chokeberry Fruits on Phytonutrients, Anti-Lipase Activity, and Antioxidant Capacity
Authors: Sosnowska Dorota , Kajszczak Dominika , Podsędek Anna
Published: November 2022

The present study investigated the nutrients, biologically-active compounds, as well as antioxidant and anti-lipase activities of chokeberry fruits across four different stages of development, from the unripe green to mature black forms. The highest content of total phenolics (12.30% dry weight (DW)), including proanthocyanidins (6.83% DW), phenolic acids (6.57% DW), flavanols (0.56% DW), flavonols (0.62% DW), and flavanones (0.10% DW), was observed in unripe fruits. The unripe green fruits were also characterized by the highest content of protein (2.02% DW), ash (4.05% DW), total fiber (39.43% DW), and chlorophylls (75.48 mg/100 g DW). Ripe black fruits were the richest source of total carotenoids (8.53 mg/100 g DW), total anthocyanins (2.64 g/100 g DW), and total sugars (33.84% DW). The phenolic compounds of green fruits were dominated by phenolic acids (above 83% of the total content), the semi-mature fruits by both phenolic acids and anthocyanins (90%), while the mature berries were dominated by anthocyanins (64%). Unripe fruits were the most effective inhibitor of pancreatic lipase in triolein emulsion, scavenger of 2,2’-azinobis-(3-ethylbenzothiazolin-6-sulfonic acid) radical cation, and reducer of ferric ion. Biological activities were mainly correlated with total proanthocyanidins and total phenolics. Considering their strong anti-lipase and antioxidant activities, unripe chokeberry fruits may have potential applications in nutraceuticals and functional foods.
Nanocellulose: A Fundamental Material for Science and Technology Applications
Authors: Poulose Aiswarya , Parameswaranpillai Jyotishkumar , George Jinu Jacob , Gopi Jineesh Ayippadath , Krishnasamy Senthilkumar , Dominic C. D. Midhun , Hameed Nishar , Salim Nisa V. , Radoor Sabarish , Sienkiewicz Natalia
Published: November 2022

Recently, considerable interest has been focused on developing greener and biodegradable materials due to growing environmental concerns. Owing to their low cost, biodegradability, and good mechanical properties, plant fibers have substituted synthetic fibers in the preparation of composites. However, the poor interfacial adhesion due to the hydrophilic nature and high-water absorption limits the use of plant fibers as a reinforcing agent in polymer matrices. The hydrophilic nature of the plant fibers can be overcome by chemical treatments. Cellulose the most abundant natural polymer obtained from sources such as plants, wood, and bacteria has gained wider attention these days. Different methods, such as mechanical, chemical, and chemical treatments in combination with mechanical treatments, have been adopted by researchers for the extraction of cellulose from plants, bacteria, algae, etc. Cellulose nanocrystals (CNC), cellulose nanofibrils (CNF), and microcrystalline cellulose (MCC) have been extracted and used for different applications such as food packaging, water purification, drug delivery, and in composites. In this review, updated information on the methods of isolation of nanocellulose, classification, characterization, and application of nanocellulose has been highlighted. The characteristics and the current status of cellulose-based fiber-reinforced polymer composites in the industry have also been discussed in detail.
Preparation of Graphene Oxide-Maghemite-Chitosan Composites for the Adsorption of Europium Ions from Aqueous Solutions
Authors: Lujanienė Galina , Novikau Raman , Joel Edith Flora , Karalevičiūtė Karolina , Šemčuk Sergej , Mažeika Kęstutis , Talaikis Martynas , Pakštas Vidas , Tumėnas Saulius , Mažeika Jonas , Jokšas Kęstutis
Published: November 2022

The adsorption of Eu(III) on composites synthesised from graphene oxide (GO), maghemite (MGH), and chitosan (CS) has been studied using different approaches. The physicochemical and morphological characteristics of the composites GO-MGH, GO-CS, GO-MGH-CS I, II, and III were determined by XRD, Mössbauer spectroscopy, FTIR, Raman spectroscopy, and TEM. According to the results of batch experiments, the maximum experimental adsorption capacity was 52, 54, 25, 103, and 102 mg/g for GO-MGH, GO-CS, GO-MGH-CS I, II, and III, respectively. The data obtained are in better agreement with the Langmuir, pseudo-second-order, and pseudo-first-order models only for GO-MGH. Thus, the adsorption of Eu(III) on the composites was a favourable, monolayer, and occurred at homogeneous sites. The nature of adsorption is chemical and, in the case of GO-MGH, physical. Tests of the composites in natural waters showed a high removal efficiency for Eu(III), Pu(IV), and Am(III), ranging from 74 to 100%. The ANFIS model has quite good predictive ability, as shown by the values for R2, MSE, SSE, and ARE. The GO-MGH-CS composites with the high adsorption capacity could be promising candidates for the removal of Eu(III) and the pre-concentration of Pu(IV) and Am(III) from natural waters.
Biosorption Characteristic and Cytoprotective Effect of Pb2+, Cu2+ and Cd2+ by a Novel Polysaccharide from Zingiber strioatum
Authors: Jiang Wei , Hu Ying , Zhu Zhenyuan
Published: November 2022

The pollution of heavy metal ions can cause damage to the human body through food, so developing a new biocompatible material that can remove the damage of heavy metal ions has a good application prospect. In this study, we obtained a new homogeneous polysaccharide composed of seven monosaccharides from Zingiber strioatum by using the method of separation and purification of polysaccharide. The results of adsorption behavior showed that the concentration, temperature and pH value could affect the adsorption effect of Zingiber strioatum polysaccharide (ZSP). Through model fitting of the data of adsorption time and metal concentration, the pseudo second-order kinetic model can well describe the kinetics of the adsorption process, and the adsorption isotherm data fit well with the Langmuir model. In the preliminary research results of adsorption mechanism, SEM showed the appearance of ZSP as flake and porous surface; EDX analysis confirmed the metal adsorption capacity of ZSP. Meanwhile, XPS and FT-IR further clarified the adsorption based on functional groups composed of C and O. The cells preprotected by ZSP can resist heavy metal ions. The above results show that ZSP can be used as a new macromolecule to bind heavy metal ions, which can broaden the research scope of polysaccharides in contaminated food systems.
Effect of Co-Existing Cations and Anions on the Adsorption of Antibiotics on Iron-Containing Minerals
Authors: Guan Xiaoyu , Guo Juntao , Zhang Hui , Tao Shiyong , Mailhot Gilles , Wu Feng , Xu Jing
Published: November 2022

The adsorption of antibiotics on minerals is an important process in their environment behavior. The adsorption behavior of antibiotics on iron-containing minerals and the effect of co-existing cations and anions were studied in this work. Magnetite, hematite, goethite and kaolin were selected as the representative minerals and characterized by SEM, XRD and BET. A total of eight antibiotics, including three quinolones, three sulfonamides and two mycins were chosen as the research targets. Results showed a higher adsorption amount of quinolones than that of sulfonamides and mycins on the surface of iron-containing minerals in most mineral systems. The adsorption isotherms of quinolones can be well fitted using the Freundlich models. The effects of five cations and five anions on the adsorption of quinolones were investigated, among which Mg2+, Ca2+, HCO3− and H2PO4− mainly showed significant inhibition on the adsorption, while the effects of K+, Na+, NH4+, Cl−, NO3− and SO42− showed less. Natural surface water samples were also collected and used as media to investigate the adsorption behavior of quinolones on iron-containing minerals. The buffering capacity of the natural water kept the reaction solution at circumneutral conditions, and the adsorption amount was mostly promoted in the goethite system (from 0.56~0.78 μmol/g to 0.52~1.43 μmol/g), but was inhibited in the other systems (magnetite: from 1.13~1.33 μmol/g to 0.45~0.76 μmol/g; hematite: from 0.52~0.65 μmol/g to 0.02~0.18 μmol/g; kaolin: from 1.98~1.99 μmol/g to 0.90~1.40 μmol/g). The results in this work help to further understand the transportation and fate of antibiotics in an aqueous environment.
Characterization of Various Titanium-Dioxide-Based Catalysts Regarding Photocatalytic Mineralization of Carbamazepine also Combined with Ozonation
Authors: Kocsis Gábor , Szabó-Bárdos Erzsébet , Fónagy Orsolya , Farsang Evelin , Juzsakova Tatjána , Jakab Miklós , Pekker Péter , Kovács Margit , Horváth Ottó
Published: November 2022

Titanium-dioxide-based semiconductors proved to be appropriate for photocatalytic application to efficiently degrade emerging organic pollutants such as various herbicides, pesticides, and pharmaceuticals in waters of environmental importance. The characterization of various TiO2 catalysts, both bare and modified (Ag- and/or N-doped), by mechanochemical treatment was carried out in this work, regarding their structure, morphology, and photocatalytic activity. For the latter investigations, carbamazepine, an antidepressant, proved to be applicable and versatile. The photocatalytic behavior of the catalysts was studied under both UV and visible light. Besides the decomposition efficiency, monitoring the intermediates provided information on the degradation mechanisms. Mechanochemical treatment significantly increased the particle size (from 30 nm to 10 μm), causing a considerable (0.14 eV) decrease in the band gap. Depending on the irradiation wavelength and the catalyst, the activity orders differed, indicating that, in the mineralization processes of carbamazepine, the importance of the different oxidizing radicals considerably deviated, e.g., Ag-TiO2 < DP25-TiO2 < ground-DP25-TiO2 < N-TiO2 ≈ N-Ag-TiO2 for O2•− and N-TiO2 ≈ Ag-TiO2 < N-Ag-TiO2 < ground-DP25-TiO2 ≈ DP25-TiO2 for HO• generation under UV irradiation. Toxicity studies have shown that the resulting intermediates are more toxic than the starting drug molecule, so full mineralization is required. This could be realized by a synergistic combination of heterogeneous photocatalysis and ozonation.
The Impact of Nitrile-Specifier Proteins on Indolic Carbinol and Nitrile Formation in Homogenates of Arabidopsis thaliana
Authors: Chroston Eleanor C. M. , Hielscher Annika , Strieker Matthias , Wittstock Ute
Published: November 2022

Glucosinolates, specialized metabolites of the Brassicales including Brassica crops and Arabidopsis thaliana, have attracted considerable interest as chemical defenses and health-promoting compounds. Their biological activities are mostly due to breakdown products formed upon mixing with co-occurring myrosinases and specifier proteins, which can result in multiple products with differing properties, even from a single glucosinolate. Whereas product profiles of aliphatic glucosinolates have frequently been reported, indole glucosinolate breakdown may result in complex mixtures, the analysis of which challenging. The aim of this study was to assess the breakdown of indole glucosinolates in A. thaliana root and rosette homogenates and to test the impact of nitrile-specifier proteins (NSPs) on product profiles. To develop a GC-MS-method for quantification of carbinols and nitriles derived from three prominent indole glucosinolates, we synthesized standards, established derivatization conditions, determined relative response factors and evaluated applicability of the method to plant homogenates. We show that carbinols are more dominant among the detected products in rosette than in root homogenates of wild-type and NSP1- or NSP3-deficient mutants. NSP1 is solely responsible for nitrile formation in rosette homogenates and is the major NSP for indolic nitrile formation in root homogenates, with no contribution from NSP3. These results will contribute to the understanding of the roles of NSPs in plants.
Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
Authors: Suwannasom Nittiya , Thepmalee Chutamas , Khoothiam Krissana , Thephinlap Chonthida
Published: November 2022

The phytochemical constituents of red (RR) and black (BR) rice extracts were determined using high-pressure liquid chromatography (HPLC). Phytochemical screening revealed the presence of catechin, rutin, isoquercetin, cyanidin 3-glucoside, cyanidin 3-O-rutinoside, peonidin and quercetin. The anti-diabetic activities of RR and BR extracts on diabetic complications were examined in a streptozotocin-induced diabetic rat model. Rats (n = 80) were divided into 10 groups (n = 8 rats per group). Healthy and diabetic RR or BR-treated groups received 10, 50, or 200 mg of RR or BR per kg of body weight daily for 45 days. The results demonstrated significantly improved glucose control in rats administered RR or BR, while triglyceride and cholesterol levels were reduced in the diabetic groups. Moreover, RR or BR treatment led to decreased levels of malondialdehyde, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and creatinine. Further, glutathione concentration was significantly increased in both serum and liver tissue from RR- and BR-treated diabetic rats.
Borate-Based Compounds as Mixed Polyanion Cathode Materials for Advanced Batteries
Authors: Sanglay Giancarlo Dominador D. , Garcia Jayson S. , Palaganas Mecaelah S. , Sorolla Maurice , See Sean , Limjuco Lawrence A. , Ocon Joey D.
Published: November 2022

Rational design of new and cost-effective advanced batteries for the intended scale of application is concurrent with cathode materials development. Foundational knowledge of cathode materials’ processing–structure–properties–performance relationship is integral. In this review, we provide an overview of borate-based compounds as possible mixed polyanion cathode materials in organic electrolyte metal-ion batteries. A recapitulation of lithium-ion battery (LIB) cathode materials development provides that rationale. The combined method of data mining and high-throughput ab initio computing was briefly discussed to derive how carbonate-based compounds in sidorenkite structure were suggested. Borate-based compounds, albeit just close to stability (viz., <30 meV at−1), offer tunability and versatility and hence, potential effectivity as polyanion cathodes due to (1) diverse structures which can host alkali metal intercalation; (2) the low weight of borate relative to mature polyanion families which can translate to higher theoretical capacity; and a (3) rich chemistry which can alter the inductive effect on earth-abundant transition metals (e.g., Ni and Fe), potentially improving the open-circuit voltage (OCV) of the cell. This review paper provides a reference on the structures, properties, and synthesis routes of known borate-based compounds [viz., borophosphate (BPO), borosilicate (BSiO), and borosulfate (BSO)], as these borate-based compounds are untapped despite their potential for mixed polyanion cathode materials for advanced batteries.
Ginsenoside Rb1 from Panax notoginseng Suppressed TNF-α-Induced Matrix Metalloproteinase-9 via the Suppression of Double-Strand RNA-Dependent Protein Kinase (PKR)/NF-κB Pathway
Authors: Sun Wen-Tao , Yang Cindy L. H. , Or Terry C. T. , Luo Dan , Li James C. B.
Published: November 2022

Chronic inflammation is commonly accompanied by the stimulation of matrix metalloproteinases (MMPs) production and the degradation of the extracellular matrix. The overexpression of MMP-9 (Gelatinase B) highly participates in the progression of pathetic cardiac remodeling and liver cancer metastasis. Panax notoginseng (Burkill) F. H. Chen (Sanqi), a widely used traditional Chinese medicinal herb, shows myocardial protective and anti-tumor effects. In this study, we examined the inhibitory effect of different PNG extracts on tumor necrosis factor (TNF)-α-induced MMP-9 expression in cardiac myoblast H9c2 cells. Using a bioassay-guided fractionation scheme, the most active extract was fractionated by silica gel column chromatography and high-performance liquid chromatography until an active compound was obtained. The compound was identified as Ginsenoside Rb1 by nuclear magnetic resonance. Ginsenoside Rb1 inhibited TNF-α-induced MMP-9 production in both H9c2 and liver carcinoma HepG-2 cells. Interestingly, it did not affect the MMP-2 (Gelatinase A) level and the cell proliferation of the two cell lines. The inhibitory effects of Ginsenoside Rb1 may be due to its modulation of double-strand RNA-dependent protein kinase and nuclear factor kappa B signaling pathways. The results reveal the potential use of Ginsenoside Rb1 for the treatment of inflammatory and MMP-9-related cardiac remodeling and metastasis of hepatocellular carcinomas.
Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted
Authors: Westphal Regina , Venturini Filho Eclair , Loureiro Laiza Bruzadelle , Tormena Cláudio Francisco , Pessoa Claudia , Guimarães Celina de Jesus , Manso Mariana Palmeira , Fiorot Rodolfo Goetze , Campos Vinicius Rangel , Resende Jackson Antônio Lamounier Camargos , Medici Fabrizio , Greco Sandro José
Published: November 2022

In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds. The reaction conditions considered ideal were determined from a methodological study varying solvent, catalyst, amount of catalyst, temperature, and heating mode. Finally, the generality of the methodology was evaluated by exploring the scope of the reaction, varying the starting materials (isatin, malononitrile, and barbituric acid). Overall, the twelve spiro compounds were synthesized in good yields (43–98%) and the X-ray structure of compound 1b was obtained. In addition, the in vitro antiproliferative activities of the spirocycles against four types of human cancer cell lines including HCT116 (human colon carcinoma), PC3 (prostate carcinoma), HL60 (promyelocytic leukemia), and SNB19 (astrocytoma) were screened by MTT-based assay. It is noteworthy that spiro compound 1c inhibited the four cell lines tested with the lowest IC50 values: 52.81 µM for HCT116, 74.40 µM for PC3, 101 µM for SNB19, and 49.72 µM for HL60.
Towards Heterogeneous Catalysis: A Review on Recent Advances of Depositing Nanocatalysts in Continuous–Flow Microreactors
Authors: Feng Hao , Zhang Ying , Liu Jian , Liu Dong
Published: November 2022

As a promising technology, microreactors have been regarded as a potential candidate for heterogeneous catalytic reactions as they inherently allow the superior advantages of precise flow control, efficient reactant transfer, flexible operation, etc. However, the wide market penetration of microreactors is still facing severe challenges. One of the most important reasons is the preparation of a high–performance catalytic layer in the microreactor because it can directly influence the catalytic activity and stability the reactor and thus the deployment the microreactor technology. Hence, significant progress in depositing nanocatalysts in microreactors has been made in the past decades. Herein, the methods, principles, recent advances, and challenges in the preparation of the catalyst layer in microreactors were presented. A general description of the physicochemical processes of heterogeneous catalytic reactions in microreactors were first introduced. Then, recent advances in catalyst layer preparation in microreactors were systematically summarized. Particular attention was focused on the most common sol–gel method and its latest developments. Some new strategies proposed recently, including bio–inspired electroless deposition and layer–by–layer self–assembly, were also comprehensively discussed. The remaining challenges and future directions of preparing the catalytic layer in microreactors with high performance and low cost were highlighted.
Triplet Emitting C^N^C Cyclometalated Dibenzo[c,h]Acridine Pt(II) Complexes
Authors: Friedel Joshua , Krause Maren , Jordan Rose , Maisuls Iván , Brünink Dana , Schwab Dominik , Doltsinis Nikos L. , Strassert Cristian A. , Klein Axel
Published: November 2022

In a series of Pt(II) complexes [Pt(dba)(L)] containing the very rigid, dianionic, bis-cyclometalating, tridentate C^N^C2− heterocyclic ligand dba2– (H2dba = dibenzo[c,h]acridine), the coligand (ancillary ligand) L = dmso, PPh3, CNtBu and Me2Imd (N,N’-dimethylimidazolydene) was varied in order to improve its luminescence properties. Beginning with the previously reported dmso complex, we synthesized the PPh3, CNtBu and Me2Imd derivatives and characterized them by elemental analysis, 1H (and 31P) NMR spectroscopy and MS. Cyclic voltammetry showed partially reversible reduction waves ranging between −1.89 and −2.10 V and increasing along the series Me2Imd < dmso ≈ PPh3 < CNtBu. With irreversible oxidation waves ranging between 0.55 (L = Me2Imd) and 1.00 V (dmso), the electrochemical gaps range between 2.65 and 2.91 eV while increasing along the series Me2Imd < CNtBu < PPh3 < dmso. All four complexes show in part vibrationally structured long-wavelength absorption bands peaking at around 530 nm. TD-DFT calculated spectra agree quite well with the experimental spectra, with only a slight redshift. The photoluminescence spectra of all four compounds are very similar. In fluid solution at 298 K, they show broad, only partially structured bands, with maxima at around 590 nm, while in frozen glassy matrices at 77 K, slightly blue-shifted (~580 nm) bands with clear vibronic progressions were found. The photoluminescence quantum yields ΦL ranged between 0.04 and 0.24, at 298 K, and between 0.80 and 0.90 at 77 K. The lifetimes τ at 298 K ranged between 60 and 14040 ns in Ar-purged solutions and increased from 17 to 43 µs at 77 K. The TD-DFT calculated emission spectra are in excellent agreement with the experimental findings. In terms of high ΦL and long τ, the dmso and PPh3 complexes outperform the CNtBu and Me2Imd derivatives. This is remarkable in view of the higher ligand strength of Me2Imd, compared with all other coligands, as concluded from the electrochemical data.
Highly Luminescent Crystalline Sponge: Sensing Properties and Direct X-ray Visualization of the Substrates
Authors: Demakov Pavel A. , Ryadun Alexey A. , Dybtsev Danil N.
Published: November 2022

A phenomenon of crystalline sponge is represented by guest-dependent structural fluidity of the host polymeric lattice in highly crystalline sorbents, such as metal-organic frameworks, driven by multiple weak intermolecular interactions. Such induced fitting in MOFs is a valuable property in selective adsorption, guest determination by single-crystal XRD and in-situ structural analysis under external stimuli. In this work, a porous three-dimensional metal-organic framework [Eu2(DMF)4(ttdc)3]·4.45DMF (1DMF; DMF = N,N-dimethylformamide, ttdc2– = trans-thienothiophenedicarboxylate anion) was applied as a crystalline sponge bearing luminescent functionality to couple its sensing properties with direct structural determination of the adsorbed molecules. As a result, the paper discusses crystal structures and luminescent properties for the successfully obtained new adducts with the crystallographic formulae [Eu2(DMSO)4(ttdc)3]·2.5DMSO·2.2H2O (1DMSO; DMSO = dimethylsulfoxide), [Eu2(DMF)4(ttdc)3]·3phet (1phet; phet = phenylethanal) and [Eu2(DMF)3.5(cin)0.5(ttdc)3]·1.64cin (1cin; cin = trans-cinnamaldehyde). As a result of inclusion of DMSO into 1, a slight increase in the quantum yield and excited state phosphorescence lifetime was observed, while the adsorption of phet leads to a considerable (up to three times) decrease in the corresponding values. The incorporation of cinnamal results in a full quenching of QY, from 20% down to zero, and a more than order of magnitude diminishing of the excited state lifetime compared to the initial 1DMF. The effective sensing of cinnamal was explained from the structural point of view by its direct coordination to the Eu3+ emitter, as well as by multiple weak intermolecular interactions with ttdc antenna ligand, both capable of enhancing the non-radiative energy dissipation.
Hydrothermal Synthesis of Siderite and Application as Catalyst in the Electro-Fenton Oxidation of p-Benzoquinone
Authors: Görmez Özkan , Saçlı Barış , Çağlayan Uğur , Kalderis Dimitrios , Gözmen Belgin
Published: November 2022

A weak aspect of the electro-Fenton (EF) oxidation of contaminants is the dependence of the Fenton reaction on acidic pH values. Therefore, the rationale of this work was to develop a novel catalyst capable of promoting the EF oxidation process at near-neutral and basic pH values. In this framework, rhombohedral FeCO3 was synthesized hydrothermally and used as a catalyst in the EF oxidation of p-benzoquinone (BQ). The catalyst was characterized using various surface and spectroscopic methods. Moreover, the effects of applied current (100–500 mA), time (1–9 h), catalyst dosage (0.25–1.00 g L−1), and initial concentration of BQ (0.50–1.00 mM) on the total organic carbon removal efficiency were determined. The results indicated that a 400 mA current was sufficient for a 95% total organic carbon removal and that the increase in catalyst dosage had a positive effect on the mineralization of BQ. It was determined that at pH 3, FeCO3 behaved like a homogeneous catalyst by releasing Fe3+ ions; whereas, at the pH range of 5–7, it shifted to a homogeneous/heterogeneous catalyst. At pH 9, it worked solely as a heterogeneous catalyst due to the decrease of Fe ions passing into the solution. Finally, the spent catalyst did not undergo structural deformations after the EF treatment at higher pH values and could be regenerated and used several times
Effect of Bentonite Addition to Pedro Ximénez White Grape Musts before Their Fermentation with Selected Yeasts on the Major Volatile Compounds and Polyols of Wines and Tentative Relationships with the Sensorial Evaluation
Authors: Muñoz-Castells Raquel , Moreno-García Jaime , García-Martínez Teresa , Mauricio Juan Carlos , Moreno Juan
Published: November 2022

In this work, we study the effect of bentonite addition to the grape must before alcoholic fermentation on the chemical composition and sensorial profile of the obtained wines. Fermentations were carried out with two Saccharomyces cerevisiae commercial active dry yeasts treated or not with bentonite and were compared with a control wine obtained by spontaneous fermentation (using the grape must microbiota). Several significant effects on the chemical and sensorial attributes were established by statistical treatments. The selection by multiple variable analysis of seven volatile molecules (ethyl acetate; methanol; 1-propanol; isobutanol; 2-methyl-1-butanol; 3-metyl-1-butanol and 2-phenylethanol) provided several footprints that provide an easy visualization of bentonite effects on wine volatile compounds. A Principal Component Analysis carried out with all the compounds quantified by Gas-Chromatography revealed that the first two Principal Components explain 60.15 and 25.91%, respectively, of the total variance and established five groups that match with the five wines analyzed. Lastly, predictive models at p ≤ 0.05 level for the attributes sight, smell and taste were obtained by Partial Least Squared regression analysis of selected chemical variables.
Rapid Removal of Organic Pollutants from Aqueous Systems under Solar Irradiation Using ZrO2/Fe3O4 Nanoparticles
Authors: Banić Nemanja , Šojić Merkulov Daniela , Despotović Vesna , Finčur Nina , Ivetić Tamara , Bognár Szabolcs , Jovanović Dušica , Abramović Biljana
Published: November 2022

Pure water scarcity is an emerging, all-around problem that globally affects both the life quality and the world’s economy. Heterogeneous photocatalysis under solar irradiation is a promising technique for the organic pollutants (e.g., pesticides, drugs) removal from an aqueous environment. Furthermore, the drawbacks of commercially available photocatalysts can be successfully overcome by using innovative nanoparticles, such as ZrO2/Fe3O4. Four ZrO2/Fe3O4 nanopowders with a different mass ratio of ZrO2 and Fe3O4 were synthesized using the chemical co-precipitation method. XRD analysis showed the presence of magnetite and hematite Fe-oxide phases in all samples. The content of the magnetite phase increased with the addition of 19% ZrO2. The efficiency of the newly synthesized ZrO2/Fe3O4 nanoparticles was investigated in the rapid removal of selected pollutants under various experimental conditions. Nevertheless, the influence of the water matrix on photocatalytic degradation was also examined. The obtained data showed that using ZrO2/Fe3O4 nanosystems, an appropriate removal rate of the selected pesticides and pharmaceuticals can be reached after 120 min of solar irradiation. Further, the total organic carbon measurements proved the mineralization of the target emerging pollutants. ZrO2/Fe3O4 nanoparticles are economically feasible, as their removal from the suspension can be easily achieved using affordable, environmentally-friendly magnetic separation.