bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of postpartum experience and infant temperament on maternal beliefs about infant crying
Authors: Hiraoka Daiki , Nomura Michio , Kato Masaharu
Published: March 2021

Infant crying is an important signal for their survival and socio-cognitive development, and maternal beliefs about crying predict responsiveness to crying. Most studies have considered caregivers’ reactions to crying to be fixed, and it is unclear how they change with their caregiving experience. Additionally, it has recently been suggested that there is a bidirectional relationship between changes in mothers’ beliefs about crying and infants’ temperament. This study examined that relationship using longitudinal study design. Maternal beliefs about crying and infant temperament of first-time mothers were measured at 1-month intervals over a 4-month period. Prior to the main survey, we conducted a pre-survey to confirm the reliability and validity of the Japanese version of the Infant Crying Questionnaire. We found that parent-oriented beliefs, which focus on the caregiver rather than the crying infant, increased with the mother’s experience, and that infants high on surgency predicted changes in maternal beliefs about infant crying. The current results suggest that the beliefs required by caregivers change with an infant’s development and parenting experience in the early postpartum period. Longitudinal studies of caregivers’ changes, such as the present study, are expected to contribute to the understanding of co-development of caregivers and infants.
Effects of mobility restrictions on mental health among young adults in the context of COVID-19 pandemic. A cross-sectional study
Authors: Carpio-Arias Tannia Valeria , Piedra Santiago , Nicolalde-Cifuentes Tomas Marcelo , Mogrovejo-Arias Diana Carolina , Padilla-Samaniego María Victoria , Tapia-Veloz Estephany Carolina , Vinueza-Veloz María Fernanda
Published: March 2021

Purpose: To explore the effects of mobility restriction on the mental health of Ecuadorian young adults. Methods: The current is a cross-sectional study that included 8426 young adults. Socio-demographic and mental health data were collected through an online survey during May-June 2020 in Ecuador. Data on mobility was extracted from Google Mobility Reports. Four aspects of the participants’ mental health were evaluated: eating behavior (emotional eating), depression, sleep quality and sense of coherence using previously validated instruments. Data were analyzed using linear regression using R. Results: Mean age of the participants was 22.85 (SD = 4.43), most of whom were women (n = 5943, 70.53%). During mandatory confinement, mobility due to retail and recreation, to groceries and pharmacies, to parks, to transit stations, to workplaces were reduced by nearly 50%. In contrast, mobility to places of residence increased by nearly 20%. Less healthy eating behavior was associated with lower mobility to retail/recreation, residential or workplaces. Depression was associated with lower mobility to residential and workplaces. Worse quality of sleep was associated with lower mobility to retail/recreation, residential and workplaces. Higher sense of coherence was associated with higher mobility to residential and to workplaces. Women and youngsters more often showed depression, less healthy eating behavior, worse quality of sleep and lower sense of coherence. Conclusion: Mobility restrictions during COVID-19 pandemic has negative effects on people's mental health. Prevention and health promotion measures directed to ameliorate the effects of confinement on mental health should target risk populations including women and youngsters.
Body Fat Percentage, Waist Circumference and Body Mass Index are Correlated with Nitric Oxide Levels in Young Adults with Central Obesity
Authors: Nauli Feriyandi , Nurhasanah Nurhasanah , Mahati Endang , Bahrudin Udin
Published: March 2021

Background: Central obesity stands for the corner-stone of cardio-metabolic health, while nitric oxide (NO) is a major regulator of cardiovascular function. To day, the correlation between serum NO metabolites nitrate/nitrite and the obesity components in young adults remains elusive. Thus, this current study was conducted to know the correlation between serum NO metabolites levels and body fat percentage, waist circumference (WC) as well as body mass index (BMI) in young adults with central obesity.Materials and Methods: A cross-sectional study was conducted in Riau, Indonesia, involving 79 young adults aged 18-25 years, composing of 39 and 40 subjects with and without central obesity, respectively. Anthropometric measurements were performed to assess WC and BMI. Body fat percentage was measured using bioelectrical impedance analysis and serum NO metabolites levels were assessed using Griess methods.Results: Levels of serum NO metabolites were significant higher in the subjects with central obesity (168.41±12.64 μmol/L) than that of normal subjects (70.57±44.99 μmol/L, p<0.001), but the levels were no significant different between male and female subjects. Serum NO metabolites levels were strongly correlated with total body fat (r=0.618, p<0.001), visceral fat (r=0.733, p<0.001), subcutaneous fat (r=0.547, p<0.001), WC (r=0.717, p<0.001) and BMI (r=0.788, p<0.001).Conclusions: For young adults in Riau, Indonesia, levels of serum NO metabolites are higher in the central obesity group than that of the normal. In this population, body fat percentage, waist circumference and body mass index are correlated with serum nitric oxide metabolites levels.Keywords: nitric oxide, body fat percentage, young adults, central obesity
Sexually Transmitted Infections (STIs) and Its Changing Scenario: A Scoping Review
Authors: Aggarwal Sumit , Singh Amit Kumar , Balaji Sivaraman , Ambalkar Deepti
Published: March 2021

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Sexually Transmitted Infections (STIs) and reproductive tract infections (RTIs) have existed worldwide since ancient times, causing significant morbidity and mortality. To maintain healthy sexual and reproductive life, it is highly essential to prevent STIs, RTIs and related illnesses. STIs are transmitted by transaction of body fluids among people during sexual intercourse. The etiological agents for STIs are bacteria, viruses and parasites in most cases, but proportions by different aetiology are varying. Various studies have shown that STIs are increasing, and their primary aetiology is changing worldwide, which should be considered seriously and needs necessary actions. Several factors related to hosts and disease-causing agents have been identified to influence STIs' current strategies in the prevention and control program. The present study attempts to review the history, changing aetiology and antimicrobial resistance in STIs. This review has also highlighted the prevalence of STIs at the global level and their past and present trends in India, emphasizing future challenges and perspectives for making effective public health policies to prevent and control STIs.
Targeting HIV-1 Envelope Proteins Using a Fragment Discovery All-Atom Computational Algorithm
Authors: Peters Michael H.
Published: March 2021

Introduction:

HIV viral envelope proteins are targets for small inhibitor
molecules aimed at disrupting the cellular entry process. Potential peptide-class inhibitor
molecules (rDNA drugs) have been previously identified, with mixed results,
through biomimicry and phage display experimental methods. Here we describe a
new approach based on computational fragment discovery. The method has the potential
to not only optimize peptide binding affinity but also to rapidly produce alternative
inhibitors against mutated strains.

Methods:

A comprehensive, all-atom implicit solvent method is used to bombard
the C-heptad repeat unit of HIV-1 target envelope protein GP41 with single Damino
acid residues as they exist in their native state. A nascent peptide computational
search process then identifies potential favorable sequences of attached ligands based on four
peptide bond criteria. Finally, dynamic simulations of nascent peptides attached to host targets help refine
potential peptide inhibitors for experimental HIV-1 challenge assays and testing.

Results and Discussion:

Initial testing of the method was done using 64,000 total ligands of D-amino
acid residues at a total computational time of 0.05 microseconds per ligand, which resulted in several
thousand attached ligands. Peptide bond criteria search employing three of the four bond constraints
with a tolerance of 20 percent, resulted in four potential peptide inhibitors of 5 to 6 residues in length.
Only one of the four peptides demonstrated IC50 values and partial viral inhibition based on cell challenge
assays using CEM-SS host cells. That peptide inhibitor also computationally demonstrated longtime
attachment and stability to a helical groove in its C-heptad target. This initial testing of peptide
fragment discovery against HIV-1 has helped us refine the protocols and identify key areas of improvement.

Conclusion:

Our methods demonstrate the potential to design efficient peptide inhibitors to viral target
proteins based on an all-atom dynamic simulation and using a ligand library as fragments of potential
nascent peptides. Our methods can be greatly improved through the use of higher numbers of ligands,
increased time of bombardment, and tighter constraints on the peptide bond search step. Our method
may be important in the need to rapidly respond to target mutations and to advance multiple targeting
methods based multiple peptide inhibitors.
Therapeutically Important Natural Products and their Derivatives as a Target for Treatment of COVID-19 (SARSCoV2)
Authors: Subhash  , Chaudhary Ashu
Published: March 2021

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An epic coronavirus sickness spread into people and quickly gotten the epidemic liable aimed at the existing worldwide emergency. As of late, corona viral plague elevated the problem of creating viable against viral by the most punctual towards forestall additional misfortunes. Sadly, neither medication nor antibody up till now confirmed to forestall and cure the ailments brought about by Corona virus. In this way, viable counteraction and treatment drugs against human coronavirus are in critical need. The article depicts examination and possible manifestations just by way of the existing natural products treatment and furthermore centers around those natural intensifies that demonstrated promising outcomes against corona infections. natural products have consistently assumed a significant job in medicate advancement process against different ailments, which brought about showing these natural products towards the battle rising freaks to CoVs. Also, discoveries of past examinations for the modulation of the immune system and the medicine used for the treatment of viral infection exercises the specific nourishments also natural products proceeding flu infection and COVID-19 came to be ordered, through the point of advancing the utilization of nutritional treatment also natural medication as per corona virus protective treatments.
La anarquía y las facciones tienen múltiples cabezas. La alegoría de la Medusa y la Hidra en el lenguaje decimonónico rioplatense
Authors: Nanni Facundo
Published: March 2021

En forma similar a lo que había ocurrido en la península ibérica con la asimilación de Napoleón Bonaparte y el monstruo bíblico de múltiples cabezas, la cultura rioplatense de las primeras décadas del siglo xix se valió de antiguas imágenes —clásicas y católicas—, para otorgar una figura deslegitimante a sus adversarios. El objetivo del presente trabajo, producto del cruce entre historiografía y análisis del discurso, es analizar el uso de este lenguaje clásico en la cultura política rioplatense de principios del siglo xix, por vía de textos como la Metamorfosis del romano Ovidio, o el General Estoria de Alfonso X “el Sabio”. Los publicistas decimonónicos rioplatenses pusieron en circulación la metáfora de la anarquía y las facciones en términos de regeneración permanente de sus cabezas, instaurando así una suerte de pedagogía política: era conveniente cortar de raíz a los elementos contrarios, emulando el carácter heroico de Perseo y Hércules en los mitos de la Medusa y la Hidra de Lerna. Un abordaje a una temática poco transitada de esta naturaleza, se inserta en un corpus de trabajos que pretenden observar la forma en la que los propios actores sociales rioplatenses dieron sentido e inteligibilidad a los cambios ocurridos en las primeras décadas decimonónicas.
Editorial. El mar y la nave. Construcción de saberes y variaciones iconográficas-históricas en las alegorías del triunfo de la Iglesia católica
Authors: Gaune Rafael , Sanfuentes Olaya
Published: March 2021

En este artículo introductorio al dossier “Emblemas, alegorías y otras imágenes del poder. Historias de éxito y fracaso”, quisiéramos proponer un acercamiento en torno a la lectura de imágenes a través de las claves hermenéuticas “éxito-fracaso” (Rocco-Lozano, 2020). Realizaremos un ejercicio descriptivo y metodológico de indagaciones libres de imágenes sobre los temas “nave” y “mar” en las alegorías del triunfo de la Iglesia católica en su expansión por el mundo, centrándonos, principalmente, en la alegoría atribuida al autor Miguel Jiménez, “El triunfo de la iglesia” (el vaso de la contemplación mística) del siglo xviii (Museo Nacional del Virreinato, Tepotzotlán). Esto nos ha guiado por diversos caminos investigativos y, sobre todo, se ha constituido como una cantera abierta de profundización que no pretende una aproximación teórica, sino más bien de posibilidades metodológicas alimentadas por los estudios de la imagen, la iconología y las trayectorias teóricas de la historia del arte y su profundidad de campo que nutren muchas de las disciplinas humanísticas. Al mismo tiempo, nombres relevantes como Aby Warburg, Erwin Panofsky, Ernst Gombrich, Michael Baxandall, Roberto Longhi, Carlo Ginzburg, Svetlana Alpers, Linda Nochlin, Susan Sontag, Ann Sutherland Harris y Jaynie Louise Anderson, entre otros (Burucúa, 2003), han marcado muchas de las reflexiones sobre las imágenes y el arte en los siglos xx y xxi y nos han ayudado a aproximarnos a los usos e interpretaciones de las imágenes.
Mirar el Cerro Rico. Formas de ver en la Villa Imperial de Potosí, siglos XVI-XVIII
Authors: Vega Palma Alejandra
Published: March 2021

Este artículo discute las condiciones de producción de la iconografía potosina colonial y, en particular, aquella elaborada por artífices que conocieron de primera mano la Villa Rica, ya fuera como pasantes o como vecinos de la ciudad. En el cruce entre el campo de la cultura visual y de la reflexión sobre géneros y tipologías textuales, se propone una revisión de imágenes surgidas del siglo xvi al xviii, las cuales muestran la fijación de una determinada forma de ver. Contra la insistencia habitual en hablar de formas convencionales de representación de Potosí y su Cerro Rico, se muestra que hay en la base de la repetición de estas imágenes un encuentro reiterado con una experiencia compartida del espacio circundante. El resultado, expresado en un doble perfil cónico del Cerro Rico y el Huayna Potosí (o pequeño Potosí) y la presencia de un pequeño cerro cónico que queda situado a la derecha del campo visual del observador, da cuenta de ejercicios de comunicación de una experiencia compartida y familiar.
FOREIGN LEARNERS’ PERCEPTION, SATISFACTION, AND LEARNING OUTCOME IN LEARNING INDONESIAN LANGUAGE
Authors: Suyitno Imam , Andayani Kusubakti , Anggari Peni Dyah , Kurniawan Taufiq , Arista Heni Dwi
Published: March 2021

Indonesian language learning institute for foreign learners emphasizes on increasing the experiences and skills of foreigners to speak Indonesian in the real context. One of the models used to achieve this is by optimizing the learning process. Therefore, this research studied the learning model and its impact on the perceptions, satisfaction, and outcomes using qualitative and quantitative approaches. The sample study consists of 21 foreign learners and 10 tutors. Data were obtained from the experiential-tutorial learning, scores of perception, satisfaction, and outcomes through interviews, questionnaires, and tutor assessment on the speaking abilities recorded on document sheets. The study found that the experiential-tutorial learning was developed based on the learners’ daily communication needs. The statistical analysis results showed that the average scores of their perception, satisfaction, and learning outcomes were in the high category. Therefore, foreign learners have a good perception and high learning satisfaction in conducting experiential-tutorial learning to increase their outcomes. These findings indicate that experiential-tutorial learning is an effective model for foreign language learners.
SELF-ESTEEM, ADVERSITY QUOTIENT AND SELF-HANDICAPPING: WHICH ASPECTS ARE CORRELATED WITH ACHIEVEMENT GOALS?
Authors: Jumareng Hasanuddin , Setiawan Edi
Published: March 2021

Psychology is one of the potential factors to be successful in physical education learning at universities. However, it is still unknown that among self-esteem, adversity quotient, and self-handicapping has more correlation with achievement goals. This quantitative correlational study aims to investigate the correlation among self-esteem, adversity quotient, self-handicapping, and achievement goals. The participants of this study were 80 female students. These student were in the third or fourth years of the participating universities. The instruments to collect the data were self-esteem, adversity quotient, self-handicapping, and achievement goal questionnaires. In statistical analysis, SPSS version 25 was used to find bivariate correlation and regression with a significance level of .05. The results show that self-esteem is positively correlated with adversity quotient, self-handicapping, and goal achievement. Then, the adversity quotient is positively correlated with self-handicapping and achievement goals. Meanwhile, self-handicapping has a negative correlation with achievement goals. To optimally achieve the goals in physical education classes, the aspects of self-esteem and adversity quotient should be correlated. However, self-esteem does not necessarily need to be correlated with self-handicapping. This study benefits the development of science, especially the field of psychology and physical education. The result of this study may be used to produce students with a high level of achievement goals in physical education learning at universities.
Presenteeism Among Nurses in Switzerland and Portugal and Its Impact on Patient Safety and Quality of Care: Protocol for a Qualitative Study (Preprint)
Authors: Pereira Filipa , Querido Ana Isabel , Bieri Marion , Verloo Henk , Laranjeira Carlos António
Published: March 2021

BACKGROUND

Nurses dispense direct care in a wide variety of settings and are considered the backbone of the health care system. They often work long hours, face emotional stress, and are at a high risk of psychosocial and somatic illnesses. Nurses sometimes fall sick but work regardless, leading to presenteeism and subsequent risks to quality of care and patient safety due to the increased likelihood of patients falling, medication errors, and staff-to-patient disease transmission.

OBJECTIVE

This study aims to understand presenteeism among frontline nurses and nurse managers in acute, primary, and long-term health care settings and to contribute to the development of future interventional studies and recommendations.

METHODS

A qualitative study based on online focus group discussions will explore the perceptions of, attitudes to, and experiences with presenteeism among frontline nurses and nurse managers. Using a pilot-tested interview guide, 8 focus group discussions will involve nurses working in acute care hospitals, primary care settings, and long-term residential care facilities in Switzerland’s French-speaking region and Portugal’s Center region. The data collected will be examined using a content analysis approach via NVivo 12 QSR International software.

RESULTS

The University of Applied Sciences and Arts Western Switzerland’s School of Health Sciences and the Polytechnic of Leiria’s School of Health Sciences in Portugal have both approved funding for the study. The research protocol has been approved by ethics committees in both countries. Study recruitment commenced in February 2021. The results of the data analysis are expected by September 2021.

CONCLUSIONS

This present study aims to gain more insight into the dilemmas facing nurses as a result of all causes of presenteeism among frontline nurses and nurse managers in different health care settings. The researchers will prepare manuscripts on the study’s findings, publish them in relevant peer-reviewed journals, exhibit them in poster presentations, and give oral presentations at appropriate academic and nonscientific conferences. Regarding further knowledge transfer, researchers will engage with stakeholders to craft messages focused on the needs of nurses and nurse managers and on disseminating our research findings to deal with the issue of nursing presenteeism.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/27963
Using a Smartphone Application for the Accurate and Rapid Diagnosis of Acute Anterior Intracranial Arterial Occlusion: Usability Study (Preprint)
Authors: Komatsu Teppei , Sakai Kenichiro , Iguchi Yasuyuki , Takao Hiroyuki , Ishibashi Toshihiro , Murayama Yuichi
Published: March 2021

BACKGROUND

Telestroke has developed rapidly as an assessment tool for patients eligible for reperfusion therapy.

OBJECTIVE

To investigate whether vascular neurologists can diagnose intracranial large vessel occlusion (LVO) as quickly and accurately using a smartphone application compared to a hospital-based desktop PC monitor.

METHODS

We retrospectively enrolled 108 consecutive patients with acute ischemic stroke in the middle cerebral artery territory who underwent magnetic resonance imaging (MRI) within 24 hours of their stroke onset. Two vascular neurologists, blinded to all clinical information, independently evaluated magnetic resonance angiography and fluid-attenuated inversion recovery images for the presence or absence of LVO in the internal carotid artery and middle cerebral artery (M1, M2, or M3) on both a smartphone application (Smartphone-LVO) and a hospital-based desktop PC monitor (PC-LVO). To evaluate the accuracy of an arterial occlusion diagnosis, interdevice variability between Smartphone-LVO and PC-LVO was analyzed using κ statistics, and image interpretation time was compared between Smartphone-LVO and PC-LVO.

RESULTS

There was broad agreement between Smartphone-LVO and PC-LVO evaluations regarding the presence or absence of arterial occlusion (Reader 1: κ=0.94; P<.001 vs Reader 2: κ=0.89; P<.001), and interpretation times were similar between Smartphone-LVO and PC-LVO.

CONCLUSIONS

The results indicate the evaluation of neuroimages using a smartphone application can provide an accurate and timely diagnosis of anterior intracranial arterial occlusion that can be shared immediately with members of the stroke team to support the management of patients with hyperacute ischemic stroke.
Impact of a Mobile Telerehabilitation Solution on Metabolic Health Outcomes and Rehabilitation Adherence in Patients With Obesity: Randomized Controlled Trial (Preprint)
Authors: Bughin François , Bui Gaspard , Ayoub Bronia , Blervaque Leo , Saey Didier , Avignon Antoine , Brun Jean Frédéric , Molinari Nicolas , Pomies Pascal , Mercier Jacques , Gouzi Fares , Hayot Maurice
Published: March 2021

BACKGROUND

Obesity is a major public health issue. Combining exercise training, nutrition, and therapeutic education in metabolic rehabilitation (MR) is recommended for obesity management. However, evidence from randomized controlled studies is lacking. In addition, MR is associated with poor patient adherence. Mobile health devices improve access to MR components.

OBJECTIVE

The aim of this study is to compare the changes in body composition, anthropometric parameters, exercise capacity, and quality of life (QOL) within 12 weeks of patients in the telerehabilitation (TR) program to those of usual care patients with obesity.

METHODS

This was a parallel-design randomized controlled study. In total, 50 patients with obesity (BMI>30 kg/m²) were included in a TR group (TRG) or a usual care group (UCG) for 12 weeks. Patients underwent biometric impedance analyses, metabolic exercise tests, actimetry, and QOL and satisfaction questionnaires. The primary outcome was the change in fat mass at 12 weeks from baseline. Secondary outcomes were changes in body weight, metabolic parameters, exercise capacity, QOL, patients’ adhesion, and satisfaction.

RESULTS

A total of 49 patients completed the study. No significant group × time interaction was found for fat mass (TRG: mean 1.7 kg, SD 2.6 kg; UCG: mean 1.2 kg, SD 2.4 kg; P=.48). Compared with the UCG, TRG patients tended to significantly improve their waist to hip ratios (TRG: −0.01 kg, SD 0.04; UCG: +0.01 kg, SD 0.06; P=.07) and improved QOL physical impact (TRG: +21.8, SD 43.6; UCG: −1.2, SD 15.4; P=.005). Significant time effects were observed for body composition, 6-minute walk test distance, exercise metabolism, sedentary time, and QOL. Adherence (95%) and satisfaction in the TRG were good.

CONCLUSIONS

In adults with obesity, the TR program was not superior to usual care for improving body composition. However, TR was able to deliver full multidisciplinary rehabilitation to patients with obesity and improve some health outcomes. Given the patients’ adherence and satisfaction, pragmatic programs should consider mobile health devices to improve access to MR. Further studies are warranted to further establish the benefits that TR has over usual care.

CLINICALTRIAL

ClinicalTrials.gov NCT03396666; http://clinicaltrials.gov/ct2/show/NCT03396666
Pemantauan Parameter Fisika dan Kimia pada Akuademineral di Laboratorium Kimia Anorganik, Departemen Kimia, Fakultas MIPA, UGM
Authors: Nugroho Wahyu
Published: March 2021

Telah dilakukan pengujian parameter fisika dan kimia terhadap akuademineral yang ada di Laboratorium Kimia Anorganik. Kegiatan ini bertujuan untuk memastikan kualitas akuademineral yang ada di Laboratorioum. Pengujian dilakukan terhadap parameter fisika (seperti : bau, zat terlarut, kekeruhan, rasa dan suhu), dan parameter kimia (Seperti : pH, kadar kation, gas-gas terlarut, zat organik, pestisida dan detergen). Metode yang digunakan mengacu pada metode uji SNI dan APHA tentang air bersih. Hasil pengujian menunjukkan semua parameter kimia dan fisika akuademineral memenuhi standar SNI dan lebih baik dibandingkan dengan akuademineral yang ada di pasaran. Akuademineral yang ada di Laboratorium Kimia Anorganik memiliki kualitas yang baik dan layak digunakan untuk kegiatan penelitian dan praktikum di laboratorium.
Validasi Alat Penelitian Hidung Elektronik dengan Senyawa Alkohol Standar
Authors: Widyastuti Widyastuti
Published: March 2021

Laboratorium Fisika Material saat ini tengah mengembangkan alat penelitian untuk mendeteksi sampel-sampel yang mengemisikan senyawa mudah menguap. ”Hidung Elektronik”. Alat ini merupakan sebuah alat sensor yang mempunyai kemampuan untuk mendeteksi zat-zat tertentu, mulai dari kandungan bahan berbahaya pada makanan seperti borax dan formalin, hingga mendeteksi sejumlah penyakit, menganalisa urine dan kebutuhan lainnya. Sehubungan dengan banyaknya pesanan alat Hidung Elektronik atau E-nose tersebut, maka kami memandang perlu adanya validasi terhadap alat yang akan diproduksi berikutnya, supaya hasilnya sama tepat dan cermat. Validasi yang kami lakukan menggunakan senyawa: aseton, etanol, metanol dan toluen. E-nose yang dikombinasikan dengan metode kemometrik memiliki hasil prediksi konsentrasi yang presisi dan memiliki repetabilitas yang baik. Selain itu, hasil penelitian ini menunjukkan bahwa reproduktibilitas sampel etanol, metanol, aseton, dan toluen berpengaruh besar terhadap pola respons masing-masing E-nose.
On ideal sumset labelled graphs
Authors: Mathai Jincy P. , Naduvath Sudev , Sreedharan Satheesh
Published: March 2021

The sumset of two sets A and B of integers, denoted by A + B, is defined as A+B = {a+b : a ∈ A, b ∈ B}. Let X be a non-empty set of non-negative integers. A sumset labelling of a graph G is an injective function f : V (G) → P(X) − {∅} such that the induced function f+ : E(G) → P(X)−{∅} is defined by f+(uv) = f(u) +f(v) ∀uv ∈ E(G). In this paper, we introduce the notion of ideal sumset labelling of graph and discuss the admissibility of this labelling by certain graph classes and discuss some structural characterization of those graphs.
Balancing Entertainment, Cost, and Educational Strength: A Design Framework for Medium-Coupling Educational Games
Authors: Atmaja Pratama Wirya , Sugiarto Sugiarto
Published: March 2021

Games are powerful tools for teaching and learning, especially in the age of Education 4.0. The rapid growth of educational games is hindered by various problems, including their development cost. The medium coupling approach, which allows an educational game to be both engaging and economical, is one potential solution to the problem; unfortunately, it has received only sporadic attention. This study aims to explore the matter of designing medium-coupling educational games through a design framework. The framework dissects an educational game’s game content and educational content into parts to be interconnected. We applied the framework to design and develop an educational role-playing game (RPG). Sixty first-year Informatics students tested the game, which presented three learning topics with different characteristics. A post-test questionnaire’s results validate the game’s entertainment and educational values while also uncovering how it works under different learning contents. A discussion with the participants gathered insightful suggestions and critiques, which, together with the questionnaire’s results, are synthesized into design principles for medium-coupling games. We conclude that the framework is useful for creating games that are entertaining, educational, and cost-efficient.
Design and Implementation LETS (Low Power Cluster Server) for Sustaining UMKM during Pandemic
Authors: Sidharta Hanugra Aulia , Sidharta Sidharta , Filipi Felix , Jaskandi Rafli Attala , Nugroho Febrian
Published: March 2021

Covid pandemic is spreading since end 2019 arround globe, this resulting several countries suffer economic crisis. Due people movement restriction and international border is closed, impact halting on export and import. Indonesia with 267,7 million people manage to overcome global crisis during 1998 and 2008 with encourage small and local industry. According data from BPS, SME support 60% GDP with Rp 7,7 Billion and provide 85 million employment. To sustain SME during customer shifting behavior, we propose small cluster server called as LETS. LETS is modular, and composed with several Raspberry Pi 4, also consume few energies compared with traditional server. Although Raspberry Pi 4 is small size with few limitations, with lightweight application (ansible, k3s, and nginx) it can provide web server service. LETS provide handling traffic up to 742 simultaneus requests, which sufficient of SME requirement.
Strategic Planning IS/IT TO Improve Business Competitiveness in Public Hospital
Authors: Bintang Janaputra Muhammad Ridho , Samopa Febriliyan , Ambarwati Sukmono Rita
Published: March 2021

Hospital competition is getting tighter, making good hospital strategic planning very important so that the Hospital can survive to develop better in a changing environment. Today's competitive advantage cannot be separated from Information Systems (IS) and Information Technology (IT). IS / IT in hospitals is currently used as a tool to create and develop innovative products, systems, and services for hospitals. The problem that occurs today is a large number of IS / IT that is made without looking at the financial side of the Hospital, thus making a number of uses of IS / IT not optimal in Hospital operational and business activities. Based on these problems, IS / IT strategic planning that also considers financial capability is needed. In this research, IS/IT strategic planning that takes into account the financial aspects is achieved using the approach of Ward and Peppard combined with Cost-Benefit Analysis. Value Chain and Critical Success Factor (CSF) analysis methods are used to analyze the current internal condition of the Hospital. Meanwhile, PEST and Porter's Five Forces analysis used external business analysis of the Hospital. The results of this study are in the form of IS business strategy recommendations, IS/IT management strategies, IT strategies, IS application portfolios, and IS/IT investment roadmaps compiled based on costs and benefits. There are 25 IS strategy recommendations, the IT strategy recommends 14 proposals to support the IS strategy based on the cost-benefit, and the IS / IT management strategy recommendations consist of 16 suggestions to support the IS strategy and IT strategy.
PARTICIPAÇÃO FEMININA NO CONSELHO DE ADMINISTRAÇÃO E A SUSTENTABILIDADE EMPRESARIAL
Authors: Nascimento Ítalo Carlos Soares do , Pessoa Adriano Fleck de Paula , Vasconcelos Alessandra Carvalho de , De Luca Márcia Martins Mendes
Published: March 2021

Fundamentado na Teoria dos Stakeholders, investiga-se a correlação entre a participação feminina no conselho de administração e a sustentabilidade empresarial, em 319 companhias listadas na B3. De natureza quantitativa, a pesquisa descritiva utilizou o teste de diferenças entre médias, a análise de correspondência múltipla e a regressão logística. A participação feminina é medida pela proporção do número de mulheres presentes no conselho em relação ao total de seus membros titulares, enquanto a proxy da sustentabilidade empresarial é mensurada a partir da participação da empresa em índices ou rankings de sustentabilidade. Os resultados indicam que as empresas sustentáveis são as que mais incluem mulheres no conselho de administração. Entretanto, os achados sugerem que a participação feminina ainda é baixa, corroborando estudos empíricos estrangeiros. Ao se confrontar as empresas sustentáveis com as demais, identificaram-se diferenças significantes no tocante à participação feminina no conselho de administração, permitindo-se concluir, com base na análise de regressão logística, que as empresas sustentáveis têm maior probabilidade de incluir mulheres no órgão colegiado, alinhando-se aos preceitos da Teoria dos Stakeholders, ao apontar que as mulheres têm uma maior preocupação com a sustentabilidade empresarial.
Enfrentando a pandemia da covid-19: a sustentabilidade empática como medida de união ante a realidade transnacional
Authors: Siqueira Garcia Heloise , Schmitt Siqueira Garcia Denise
Published: March 2021

Este artigo é desenvolvido no contexto de uma pandemia decorrente da doença chamada “covid-19”, que é causada pelo novo coronavírus. Trata-se de uma família de vírus que causa infecções respiratórias e é de fácil contaminação entre humanos e que apresentou rápida disseminação a diversos países em 2020. Diante dessa realidade, a pesquisa e a manifestação acadêmica são necessárias na busca de medidas, instrumentos, políticas e princípios capazes, de alguma forma, de mitigar as consequências negativas da pandemia da covid-19. A partir de critérios filosóficos e teóricos, o artigo tem como objetivo geral apresentar a sustentabilidade empática como medida de união para o enfrentamento das consequências dessa pandemia a partir de uma perspectiva transnacional. Ao final, constata-se que a superação das consequências negativas dependerá da atuação conjunta de pessoas e nações de todo o globo, já que a pandemia é claramente uma demanda desterritorializada, a qual deve acontecer por meio da sustentabilidade empática. Para a elaboração do artigo, foi utilizado o método indutivo, com as técnicas do referente, da categoria, dos conceitos operacionais, da pesquisa bibliográfica e do fichamento.
Molecular characterization of endophytic fungal communities associated with Vitis vinifera L. at Taif region of Saudi Arabia
Authors:   Department of Science and Technology, University College of Ranyah, Taif University, Taif-21974, Saudi Arabia, Sayed S.M. , El-Shehawi A.M. ,   Department of Biotechnology, Faculty of Science, Taif University, Taif-21974, Saudi Arabia, Elarnaouty S.A. ,   Department of Economic Entomology, Faculty of Agriculture, Cairo University, Giza-12613, Egypt, Al-Otaibi S.A. ,   Department of Biotechnology, Faculty of Science, Taif University, Taif-21974, Saudi Arabia, El-Shazly S.A. ,   Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheikh 33511, Egypt, Alotaibi S.S. ,   Department of Biotechnology, Faculty of Science, Taif University, Taif-21974, Saudi Arabia, Ibrahim R. ,   Department of Biology, Faculty of Science, Taibah University, Medina 344, Saudi Arabia, Ahmed M.M. ,   Department of Biochemistry, Faculty of Veterinary Medicine, University of Sadat City, 32958, Egypt, Elseehy M.M. ,   Department of Genetics, Faculty of Agriculture, Alexandria University, Alexandria-21526, Egypt
Published: March 2021

Aim: The current study aimed to characterize the composition of endophytic fungal communities related to Taify grapevine leaves. Methodology: Taify grapevine leaves were collected from three different locations at Taif region. Total DNA was extracted and the endophytic fungal communities were investigated using next generation sequencing in a metagenomics approach. Results: The obtained data detected 26 fungal operational taxonomic units (OTUs) in all locations with variation in most taxa among three locations. The phylum Ascomycota dominated relative sequence abundance (90.83%), followed by Basidiomycota at 1.82%. Other unidentified fungi at phylum level dominated 7.35% abundance level. At genus level, Alternaria and Cladosporium genera were present at all locations, while Filobasidium and Didymella were detected in two locations. Most genera, Penicillium, Hanseniaspora, Fusarium, Chrysocorona and Quambalaria were detected in one location only. Interpretation: The present study confirmed the diversity of endophytic fungi in Taify grapevine, including pathogenic and non-pathogenic species. The detected species have potential to be used as biocontrol species against economically important pathogens such as Alternaria and Hanseniaspora. This will contribute to our understanding of grapevine-endophytic fungi interaction and their utilization to enhance grapevine production and quality. Key words: Endophytes, Fungi, Grapevine, Metagenomic, Next generation sequencing
A alteridade torcedora
Authors: Lopes Felipe Tavares Paes
Published: March 2021

Este trabalho discute a pertinência da abordagem antropológica como instrumento científico para a análise das práticas dos torcedores organizados. Para tanto, baseia-se, principalmente, na discussão feita por François Laplantine sobre essa abordagem. Entre outras coisas, mostra que, ao situar-se na intersecção entre observador e o observado, essa abordagem permite apreender as formas de pensar, de sentir e de viver desses torcedores, reconhecendo sua alteridade.
Narrativas, futebol e ensino
Authors: Trevisam Kleber , Reigota Marcos Antonio dos Santos
Published: March 2021

O presente artigo tem por objetivo apresentar as narrativas resultantes da experiência em se ensinar futebol em Changhua, pequena cidade no interior de Formosa (Taiwan) onde as principais modalidades praticadas por jovens e crianças são o beisebol e o basquetebol. As narrativas apresentam as expectativas criadas com a viagem, a chegada na ilha, o conhecimento sobre o “Summer Camp” e as curiosidades que resultaram em trabalho extra pois, além do futebol, a curiosidade em torno do Brasil que muitas vezes se sobrepunha ao desejo de aprender o esporte.
Das matrizes documentais à memória no futuro
Authors: Araújo Denize Correa
Published: March 2021

Este estudo é parte final de minha pesquisa sobre a trajetória dos diários confessionais e autorretratos desde o período do Renascimento até documentários autobiográficos e biopics atuais, e também reflete a pesquisa de meu pós-doutorado sobre éticas e estéticas em imagens das ditaduras. Esta parte do estudo desenvolve dois conceitos: o da imagem-memória e o da imagem-homenagem. O objetivo central é sugerir que documentários poderão ser, no futuro, a memória do passado. O corpus é formado pelo biopic David Lynch, A Vida de um Artista (2016) e pelo autobiográfico Dor e Gloria (2019). A metodologia é baseada no método histórico-dialético de Gadamer. O referencial teórico inclui conceitos de memória de Halbwachs, Sarlo, Le Goff, Ricoeur, Pollak e Nora, além do conceito de desconstrução de Derrida, dos estudos de Arlindo Machado, Nichols e Penafria sobre documentário e subjetividade, e de Bellour e Lebow sobre o eu ficcional/documental.
The prevalence of HLA-I LOH in Chinese pan-cancer patients and genomic features of patients harboring HLA-I LOH
Authors: Zhao Jian , Xiao Xiaoxiong , Li Yue , Gao Xuan , Zhang Xiuqin , Liu Zeyi , Yi Yuting , Fu Xiaorui , Wang Han , Guan Yanfang , Xia Xuefeng , Zhang Weixing , Huang Jian'an
Published: March 2021

Loss of heterozygosity in HLA-I (HLA-I LOH) may facilitate immune
evasion. However, the large population study of HLA-I LOH in Chinese
pan-cancer patients remains to be explored. In this study, analysis was
performed in 1504 advanced pan-cancer patients and 134 early-stage NSCLC
patients using a 1021-gene panel. The consistency between the 1021-gene
panel and whole-exome sequencing (WES) was evaluated in 45 samples,
where concordant results were obtained in 95.6% (43/45) of the samples.
Analytical results revealed that the prevalence of HLA-I LOH presents
considerable differences across cancer types. HLA-I LOH was relevant to
genomic instability, reflected in higher tumor mutation burden (TMB)
level. The incidence of HLA-I LOH in MSS samples was significantly
higher than that in MSI-H samples. The alteration frequencies of p53
pathway, RTK/RAS pathway, Notch pathway, Hippo pathway, and Nrf2 pathway
in HLA-I LOH group were significantly higher than that in HLA-I stable
group (p<0.0001, p<0.0001, p=0.032, p=0.013,
p=0.003, respectively). In DNA damage response (DDR) pathways,
alterations in CPF pathway and FA pathway are enriched in HLA-I LOH
group (p<0.0001, p=0.023, respectively). Besides, HLA-I LOH
was accompanied by higher mutation rates of several tumor suppressors,
including TP53 and LRP1B. These results may shed light on follow-up
research.
Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report
Authors: Lin Andrea , Mack Jasmine A. , Bruggeman Brittany , Jacobsen Laura M. , Posgai Amanda L. , Wasserfall Clive H. , Brusko Todd M. , Atkinson Mark A. , Gitelman Stephen E. , Gottlieb Peter A. , Gurka Matthew J. , Mathews Clayton E. , Schatz Desmond A , Haller Michael J.
Published: March 2021

Previously, we demonstrated low-dose anti-thymocyte
globulin (ATG) and granulocyte colony stimulating factor (GCSF) immunotherapy preserved
C-peptide for two years in a pilot study of subjects with established type 1
diabetes (n=25). Herein, we evaluated the long-term outcomes of ATG/GCSF in
study participants with five years of available follow-up data (n=15). The
primary endpoint was area under the curve (AUC) C-peptide during a two-hour
mixed-meal tolerance test (MMTT). After five years, there were no statistically significant
differences in AUC C-peptide when comparing subjects who received ATG/GCSF versus
placebo (p = 0.41). A modeling
framework based on mean trajectories in C-peptide AUC over five years, accounting
for differing trends between groups, was applied to re-categorize responders
(n=9) and non-responders (n=7). ATG/GCSF reponders demonstrated nearly
unchanged HbA1c over five years [mean (95% CI) adjusted change = 0.29% (-0.69%, 1.27%)], but the study was not powered for
comparisons against non-responders 1.75% (-0.57%, 4.06%) and placebo 1.44%
(0.21%, 2.66%). These data
underscore the importance of long-term follow up in previous and ongoing phase 2 trials of low-dose ATG in recent-onset
type 1 diabetes.
Seroprevalence and Incidence of Chlamydia Trachomatis on Sperm Quality in Men of Procreating Age in Brazzaville
Authors: Roland M0UKALA David Charles , AH0MB0 Gabriel , AMPA Raoul , SILOU MASSAMBA Jacques François , NGUIMBI Etienne , K0MB0 Yvon Sévérin
Published: March 2021

Chlamydia trachomatis is responsible for male infertility. The mechanism of action of C. trachomatis on male reproductive function is still controversial. The present study aims to evaluate seroprevalence and its influence on sperm quality in a male sample of 307 patients requesting serological examination for C. trachomatis, 73 of whom were examined by sperm analysis - spermocytogram and sperm culture. The patients were aged between 17 and 71 years, consulting for infertility or urology. The analysis of C. trachomatis serologies, based on the enzyme immunoassay dosage of immunoglobulin G, yielded 111 cases of positive serology, i.e. a seroprevalence of 36.2%. The age group over 60 years of age, the least represented group, had the highest frequency at 52.9%. Analysis of the 73 spermograms and spermocytograms revealed a non-significant difference in mean sperm concentration, 49.67 million sperm per milliliter, standard deviation ±45.71, in Chlamydia negative subjects versus 7.66 million sperm per milliliter, standard deviation ±10.98, in Chlamydia positive subjects. A non-significant change in total motility of 39.83%, standard deviation ±27.49, in Chlamydia-negative subjects versus 36.03%, standard deviation ±24.58, in Chlamydia-positive subjects, a 3% drop. Abnormal sperm forms, 51.86%, standard deviation ±19.60, in Chlamydia negative versus 57.17%, standard deviation ±21.41, in Chlamydia positive, an increase of 6%. The global reading of the average spermogram of Chlamydia positive individuals revealed oligospermia and asthenospermia as abnormalities. This suggests that there is a possible link between C. trachomatis infection and decreased sperm quality in Chlamydia positive patients.
Surgical Removal of a Focal Fibrous Hyperplasia: Two Case Reports
Authors: Yousra Zemmouri , Saliha Chbicheb
Published: March 2021

Focal fibrous hyperplasia is the most common epithelial benign tumor of the oral cavity. It is a localized reactive progressive, proliferation of oral mucosa in response to injury or local irritation. Females are twice more likely to develop fibroma than male.
Surgical excision is performed and histological examination of the excised specimen and definitive diagnosis was obtained. This paper reports two cases of focal fibrous hyperplasia in both maxillary and mandibular locations.
Why Asymptomatic COVID19 Patient Could Face a Sudden Death
Authors: Zaher Amr , Ali Sara
Published: March 2021

Since the novel SARS-COV 2 has emerged from its inception in December 2019 till November 2020 about 68,587,138 infected cases,47,482,639 recovered, and 1,563,468 deaths [1,2]. Most of the death cases were diagnosed with critically ill pneumonia correlated with acute respiratory distress syndrome (ARDS) [2]. All of the previous numbers mostly have been recorded based on the patients who displayed symptoms whether from the most common symptoms like fatigue, cough, fever or severe symptoms as trouble breathing, persistent pain, or pressure in the chest. However, there are many infected people but didn't show any symptoms although they were developing COVID 19 complications, and some of them even died before know that they had a COVID 19. This is one of the most mysterious actions of coronavirus and bewildered the physicians how the patient could lose his oxygen gradually without panting to catch up his breath. In other words, asymptomatic patients who look completely fine don’t necessarily far from the risk; they perhaps internally suffer from silent hypoxia or lung damage.