bluuebunny/crossref_metadata_2025 huggingface dataset:
Intravitreal Injections for Macular Edema Secondary to Retinal Vein Occlusion: Long-Term Functional and Anatomic Outcomes
Authors: Maggio Emilia , Mete Maurizio , Maraone Giorgia , Attanasio Marcella , Guerriero Massimo , Pertile Grazia
Published: February 2020

Purpose. To report the long-term visual and anatomic outcomes of intravitreal injections for macular edema (ME) secondary to retinal vein occlusion (RVO) in a real-life clinical setting. Design. Retrospective interventional case series. Methods. A total of 223 consecutive eyes with ME secondary to RVO, treated with the first three intravitreal Ranibizumab or dexamethasone injections between August 2008 and September 2018, were enrolled in the study. Subsequent retreatment was guided by best-corrected visual acuity (BCVA) and central macular thickness (CMT) measurements, aimed at achieving macular fluid regression and BCVA stability. BCVA and CMT were recorded at baseline and at subsequent annual time points. The mean number of injections administered each year and the incidence of adverse events were recorded. Results. The mean BCVA and CMT at baseline were 0.79 logMar (SD 0.71) and 615.7 μm (SD 257.5), respectively. The mean follow-up (FU) period was 47.8 months (min 12–max 120). At 12 months, the mean BCVA and CMT had significantly improved to 0.62 logMar (SD 0.68; p<0.0001) and 401.04 μm (SD 183.8; p<0.0001). Improvements remained significant at the final FU visit. Eyes with BRVO and nonischemic RVO showed significantly better visual outcomes when compared to eyes with CRVO and ischemic RVO, over the entire FU period. An average of 4.08 (SD 2.1) Ranibizumab and 1.5 (SD 0.6) Ozurdex injections were administered over the first 12 months. The number of injections decreased thereafter progressively. One eye with CRVO developed endophthalmitis and one with BRVO developed an intraocular pressure increase that was refractory to topical medications and ultimately treated with trabeculectomy. Conclusion. Intravitreal Ranibizumab and/or dexamethasone injections were found to be effective at inducing a long-lasting improvement of BCVA and CMT in a real-life clinical setting. A safety profile similar to that already well-established in Ranibizumab and dexamethasone treatment was observed, as well as a steady decrease in the number of intraocular injections required. The results support intravitreal treatments for BRVO and CRVO in patient populations with similar characteristics in similar settings.
Association between Normal Thyroid Hormones and Diabetic Retinopathy in Patients with Type 2 Diabetes
Authors: Zou Jian , Li Zeping , Tian Feng , Zhang Yi , Xu Chao , Zhai Jiajia , Shi Min , Wu Guangxian , Zhang Zheng , Yang Chao , Chen Haixu , Li Xiaomiao
Published: February 2020

The relationship between normal thyroid function and type 2 diabetes mellitus (T2DM) has been a particular focus for concern. The present study determined the relationship between thyroid hormone levels and the prevalence of diabetic retinopathy (DR) in T2DM patients. A cross‐sectional study (n = 633) was performed in Xi’an, Shaanxi Province, China. Subjects were evaluated for anthropometric measurements, thyroid function, and diabetic retinopathy. Logistic regression models were used to assess the relationships between thyroid hormones and DR. Of 633 patients, 243 (38.4%) patients suffered from DR. The prevalence of DR showed a significantly decreasing trend across the quartiles based on free triiodothyronine (FT3) (FT3 quartile 1 group [FT3‐Q1] <4.35 pmol/L, FT3 quartile 2 group [FT3‐Q2] 4.35–4.70 pmol/L, FT3 quartile 3 group [FT3‐Q3] 4.70–5.08 pmol/L, and FT3 quartile 4 group [FT3‐Q4] ≥5.08 pmol/L) (56.7%, 42.5%, 33.1%, 23.8%, P < 0.001). In comparison with all participants categorized in FT3‐Q1, the multivariable adjusted odds ratios (95% confidence interval) of DR in FT3‐Q2, FT3‐Q3, and FT3‐Q4 were 0.587 (0.340–1.012), 0.458 (0.258–0.813), and 0.368 (0.201–0.673), (P = 0.055, P = 0.008, P = 0.001), respectively. FT3 levels within the normal range are negatively associated with DR in euthyroid patients with type 2 diabetes. Further studies should be aimed at clarifying the relationship between thyroid hormones and T2DM.
Completeness Theorem for Eigenparameter Dependent Dissipative Dirac Operator with General Transfer Conditions
Authors: Li Kun , Zhang Maozhu , Cai Jinming , Zheng Zhaowen
Published: February 2020

This paper deals with a singular (Weyl’s limit circle case) non-self-adjoint (dissipative) Dirac operator with eigenparameter dependent boundary condition and finite general transfer conditions. Using the equivalence between Lax-Phillips scattering matrix and Sz.-Nagy-Foiaş characteristic function, the completeness of the eigenfunctions and associated functions of this dissipative operator is discussed.
Comparison between Arm Port and Chest Port for Optimal Vascular Access Port in Patients with Breast Cancer: A Systematic Review and Meta‐Analysis
Authors: Liu Ye , Li Li-li , Xu Lei , Feng Dong-dong , Cao Yu , Mao Xiao-yun , Zheng Jin , Jin Feng , Chen Bo
Published: February 2020

Objectives. This meta‐analysis was conducted to compare the complication rates between arm and chest ports in patients with breast cancer. Design and Data Sources. PubMed, Embase, Cochrane library, Chinese National Knowledge Infrastructure (CNKI), and Wanfang database were used to perform a systematic review and meta‐analysis of publications published from the inception of the database to 11, October 2019. Our search generated a total of 22 articles published from 2011 to 2019, including 6 comparative studies and 16 single‐arm articles, involving 4131 cases and 5272 controls. Single‐arm studies combined with comparative studies were also pooled and analyzed. Finally, subgroup analysis was performed to compare the rates of infection and thrombosis between these two ports. Eligibility Criteria. Included articles were research studies comparing complication rates of arm ports with chest ports in patients with breast cancer. Any review or meta‐analysis article would be removed. Data Extraction and Synthesis. Demographic data and information for the following analysis were extracted. DerSimonian and Laird random effect meta‐analysis was conducted to analyze comparative studies while Begg’s and Egger’s tests were used for assessment of publication bias. Meta‐regression analysis was performed to explain the sources of heterogeneity. Results. There was no difference in the risk of overall complications between arm and chest ports for comparative studies (P = 0.083). While results of pooled comparative and single‐arm studies indicated that arm port would increase the overall complication risks with RR of 2.64, results of the subgroup analysis showed that there was no difference in the risk of catheter‐related infection between these two ports. However, arm port might be associated with the higher thrombosis rates compared with chest port according to the results of the analysis for only comparative studies (RR = 2.23, P = 0.041) as well as pooled comparative and single‐arm studies (RR = 1.21, P = 0.029). Conclusions. This study indicated that the arm port might increase the risk of overall complication risks as well as the risk of catheter‐related thrombosis compared with the chest port. However, these reported findings still need to be verified by large randomized clinical trials.
Exploring the Benefits of Annular Rectangular Rib for Enhancing Thermal Efficiency of Nonpremixed Micro-Combustor
Authors: Wang Hongcai , Fang Hongru , Lou Bingqian , Abubakar Shitu , Li Yuqiang , Meng Lei
Published: February 2020

Micro-combustor can provide the required thermal energy of micro-thermal photovoltaic (MTPV) systems. The performance of MTPV is greatly affected by the effectiveness of a micro-combustor. In this study, a numerical simulation was conducted to explore the benefits of annular rectangular rib for enhancing the thermal performance of a nonpremixed micro-combustor. Based on the investigations under various rib heights, rib positions, and inlet mass flow rates, it is found that the addition of annular rectangular ribs in the micro-combustor creates a turbulent zone in the combustion chamber, thereby enhancing the heat transfer efficiency between the inner wall of the combustion chamber and the burned gas. The micro-combustor with annular rectangular rib shows a higher and more uniform wall temperature. When the H2 mass flow is 7.438 × 10−8 kg/s and the air mass flow is 2.576 × 10−6 kg/s, the optimum dimensionless rib position is at l = 6/9 and r = 0.4. At this condition, the micro-combustor has the most effective and uniform heat transfer performance and shows significant decreases in entropy generation and exergy destruction. However, the optimum l and r significantly depend on the inlet mass flow of H2/air mixture.
LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance
Authors: Roberts Melyssa S. , Sahni Jennifer M. , Schrock Morgan S. , Piemonte Katrina M. , Weber-Bonk Kristen L. , Seachrist Darcie D. , Avril Stefanie , Anstine Lindsey J. , Singh Salendra , Sizemore Steven T. , Varadan Vinay , Summers Matthew K. , Keri Ruth A.
Published: February 2020

A significant therapeutic challenge for patients with cancer is resistance to chemotherapies such as taxanes. Overexpression of LIN9, a transcriptional regulator of cell-cycle progression, occurs in 65% of patients with triple-negative breast cancer (TNBC), a disease commonly treated with these drugs. Here, we report that LIN9 is further elevated with acquisition of taxane resistance. Inhibiting LIN9 genetically or by suppressing its expression with a global BET inhibitor restored taxane sensitivity by inducing mitotic progression errors and apoptosis. While sustained LIN9 is necessary to maintain taxane resistance, there are no inhibitors that directly repress its function. Hence, we sought to discover a druggable downstream transcriptional target of LIN9. Using a computational approach, we identified NIMA-related kinase 2 (NEK2), a regulator of centrosome separation that is also elevated in taxane-resistant cells. High expression of NEK2 was predictive of low survival rates in patients who had residual disease following treatment with taxanes plus an anthracycline, suggesting a role for this kinase in modulating taxane sensitivity. Like LIN9, genetic or pharmacologic blockade of NEK2 activity in the presence of paclitaxel synergistically induced mitotic abnormalities in nearly 100% of cells and completely restored sensitivity to paclitaxel, in vitro. In addition, suppressing NEK2 activity with two distinct small molecules potentiated taxane response in multiple in vivo models of TNBC, including a patient-derived xenograft, without inducing toxicity. These data demonstrate that the LIN9/NEK2 pathway is a therapeutically targetable mediator of taxane resistance that can be leveraged to improve response to this core chemotherapy.

Significance:

Resistance to chemotherapy is a major hurdle for treating patients with cancer. Combining NEK2 inhibitors with taxanes may be a viable approach for improving patient outcomes by enhancing mitotic defects induced by taxanes alone.
Pharmacodynamic Analysis of BTK Inhibition in Patients with Chronic Lymphocytic Leukemia Treated with Acalabrutinib
Authors: Alsadhan Anfal , Cheung Jean , Gulrajani Michael , Gaglione Erika M. , Nierman Pia , Hamdy Ahmed , Izumi Raquel , Bibikova Elena , Patel Priti , Sun Clare , Covey Todd , Herman Sarah E.M. , Wiestner Adrian
Published: February 2020

Purpose:

To determine the pharmacodynamic relationship between target occupancy of Bruton tyrosine kinase (BTK) and inhibition of downstream signaling.

Patients and Methods:

Patients with chronic lymphocytic leukemia (CLL) enrolled in a phase II clinical trial (NCT02337829) with the covalent, selective BTK inhibitor acalabrutinib donated blood samples for pharmacodynamic analyses. Study design included randomization to acalabrutinib 100 mg twice daily or 200 mg once daily and dose interruptions on day 4 and 5 of the first week. BTK occupancy and readouts of intracellular signaling were assessed sequentially between 4 and 48 hours from last dose.

Results:

Four hours from last dose, BTK occupancy exceeded 96% and at trough, was higher with twice daily, median 95.3%, than with once daily dosing, median 87.6% (P < 0.0001). By 48 hours from last dose, median free BTK increased to 25.6%. Due to covalent binding of acalabrutinib, free BTK is generated by de novo synthesis. The estimated rate of BTK synthesis varied widely between patients ranging from 3.6% to 31.4% per day. Acalabrutinib reduced phosphorylation of BTK and inhibited downstream B-cell receptor (BCR) and NFκB signaling. During dosing interruptions up to 48 hours, expression of BCR target genes rebounded, while phosphorylation of signaling molecules remained repressed. In vitro cross-linking of IgM on CLL cells obtained 36 to 48 hours from last dose upregulated CD69, with high correlation between cellular free BTK and response (R = 0.7, P ≤ 0.0001).

Conclusions:

Higher BTK occupancy was achieved with twice daily over once daily dosing, resulting in deeper and more sustained inhibition of BCR signaling.
Chronic Lymphocytic Leukemia with Divergent Richter’s Transformation into a Clonally Related Classical Hodgkin’s and Plasmablastic Lymphoma: A Case Report
Authors: Gasljevic Gorana , Grat Mateja , Kloboves Prevodnik Veronika , Grcar Kuzmanov Biljana , Gazic Barbara , Lovrecic Luca , Podgornik Helena
Published: February 2020

Chronic lymphocytic leukemia (CLL) typically pursues a prolonged course. Its transformation into a more aggressive lymphoma occurs in 2–8% of all patients. Most commonly, diffuse large B-cell lymphoma develops. Transformation into a classical Hodgkin’s lymphoma (cHL) occurs in <1%. Plasmablastic transformation has been only rarely reported. Cases of synchronous divergent transformation of CLL into a composite lymphoma are exceedingly rare. We describe the unique occurrence of the transformation of a long-standing CLL into a synchronous clonally related cHL as well as plasmablastic lymphoma (PBL) in an 85-year-old female patient. After 10 years of asymptomatic CLL, our patient was treated with a rituximab-chlorambucil scheme in combination with pegfilgrastim for recurrent infections and the development of B symptoms. Five cycles (of six planned) were administrated with no adverse effects. After the fifth cycle, lymphadenopathy with pronounced B symptoms appeared. Histology showed the presence of cHL in the lymph node, while the bone marrow was infiltrated by PBL. Our patient died in sepsis not receiving further specific oncologic treatment due to her poor general condition. Additional cytogenetic and molecular studies showed that this was a case of mutated CLL with trisomies of chromosomes 12, 3, and 18 (a rare specific +12 plus other-non+19 CLL subgroup). The presence of trisomy 12 has also been proved in plasmablasts and in cHL cells.
Breast Cancer Patient with Li-Fraumeni Syndrome: A Case Report Highlighting the Importance of Multidisciplinary Management
Authors: Cirauqui Beatriz , Morán Teresa , Estival Anna , Quiroga Vanesa , Etxaniz Olatz , Balana Carmen , Navarro Matilde , Villà Salvador , Ballester Rosa , Margelí Mireia
Published: February 2020

Germline mutations in TP53, a tumor suppressor gene, are involved in the development of Li-Fraumeni syndrome, a rare disorder that predisposes carriers to multiple tumors. TP53 mutations have been associated with resistance to treatment and poor prognosis. A young female with the pathogenic germline TP53 mutation c.844C > T (p.R282W) was diagnosed with two metachronous breast tumors, one HER2-negative and the other HER2-positive. She was later diagnosed with synchronous glioblastoma, epidermal growth factor receptor-mutated lung adenocarcinoma, and HER2-negative breast cancer metastases. The patient was treated with local therapies, including brain surgery and radiotherapy, lung surgery, and a bilateral mastectomy, as well as with targeted systemic treatment. She proved to be highly sensitive to systemic therapy, and 13 years after the initial diagnosis of breast cancer and 6 years after the diagnosis of the two new primary tumors and recurrence of a prior cancer, she is alive with an excellent performance status. This surprising positive evolution may well be partly due to the pronged multidisciplinary approach to managing her disease and her extraordinary response to treatment: the lung adenocarcinoma showed excellent response to erlotinib; the breast cancer responded extremely well to eribulin and pegylated liposomal doxorubicin; and the glioblastoma has remained in response to surgery and radiotherapy. Despite harboring a TP53 mutation and having multiple tumors, this patient has shown an unexpectedly favorable evolution. The coordinated participation of a multidisciplinary team and the patient’s own extraordinarily high sensitivity to systemic treatment played a major role in this evolution.
Atitudes dos professores de ensino fundamental e médio frente ao uso de substâncias psicoativas
Authors: Perez Ana Beatriz Nogueira , Zerbetto Sônia Regina , Gonçalves Angelica Martins de Souza
Published: February 2020

O objetivo do estudo foi avaliar as atitudes dos professores de Ensino Fundamental e/ou Médio diante do uso de substâncias psicoativas, em sua função laboral. Trata-se de estudo descritivo e transversal. Participaram 75 professores de quatro instituições municipais e estaduais de dois municípios, que responderam um questionário contendo informações sociodemográficas e Drug and Drug Problems Perceptions Questionnaire. Utilizaram-se estatísticas descritivas e inferenciais para análise dos dados. Os resultados mostraram indiferença dos professores acerca do tema; aqueles que já haviam participado de capacitação tiveram atitudes mais negativas; os do sexo masculino, entretanto, atitudes mais positivas. Concluiu-se que tais atitudes evidenciam emergência de ações coletivas, preventivas que vinculem saúde e educação.
Ontogenetic and sexual variation in the sagitta otolith of Menticirrhus americanus (Teleostei; Sciaenidae) (Linnaeus, 1758) in a subtropical environment
Authors: Carvalho Barbara Maichak de , Volpedo Alejandra Vanina , Fávaro Luís Fernando
Published: February 2020

This study aimed to verify variations in the form of the sagitta otolith of Menticirrhus americanus as to their ontogeny, sex and stage of such structure. Ontogenetically were found significant differences (p < 0.05) for all shape indices (aspect ratios, shape factor, rectangularity, ellipticity, relative surface of sulcus acusticus) and also in the wavelet of the otolith. The CVA presented a 98.6% correct reclassification of the otolith between interval class. Sexual variations were found in the wavelet and in the relative surface of sulcus acusticus index. Between adult females and young females, differences were not detected in the wavelet and rectangularity, but significant differences were found in all other shape indices. The CVA presented a 79.6% correct reclassification of the otolith of the sexes and stages of life sampled. Young females and adults females showed highest correct percentage of classification. The results of this study demonstrate for the first time the influence of the ontogenetic variation and sexual in the form of the otoliths.
A new synonym and seventeen new distributional records in South American Cerambycidae (Coleoptera), with notes on Chlorethe scabrosa Zajciw, 1963
Authors: Santos-Silva Antonio , Botero Juan Pablo , Nascimento Francisco Eriberto de Lima , Silva Weliton Dias
Published: February 2020

We studied 18 cerambycid beetle species native to South America. Seventeen represent new state records in Brazil. Particularly, Chlorethe scabrosa Zajciw, 1963 is newly reported for the state of Rio de Janeiro with exclusion of C. brachyptera Zajciw, 1963. The Brazilian state of the type locality of Dufauxia guaicurana Lane, 1955 is fixed. Pirangoclytus mendosus (Galileo & Martins, 1996) is synonymized with P. mniszechii (Chevrolat, 1862), and its holotype is a female. Variation on Trypanidius maculatus Monné & Delfino, 1980 is commented. New country and department records for Paraguay are also provided.
A influência das relações e o uso de álcool por adolescentes
Authors: Benincasa Miria , Tavares Ana Luiza , Barbosa Vivian Miucha Moura , Lajara Mayara De Paula , Rezende Manuel Morgado , Heleno Maria Geralda Viana , Custódio Eda Marconi
Published: February 2020

O álcool é a substância cada vez mais presente no consumo de adolescentes. O presente estudo teve como objetivo descrever sobre uso de álcool e a qualidade das relações sociais entre familiares, amigos e identificar como estas influenciam no consumo de álcool. Trata-se de um estudo transversal cujos dados coletados foram com uma amostra de 2423 estudantes, matriculados no Ensino Médio. Os dados expressam a significante presença do álcool nas relações e a ligação de uso com as relações tanto familiares como sociais de pares, independente da qualidade percebida nessas relações. Os dados são relevantes para se pensar na efetividade das intervenções de políticas públicas considerando os vínculos familiares e sociais.
O auto-estigma dos usuários de álcool e drogas ilícitas e os serviços de saúde
Authors: Fernandes Raquel Helena Hernandez , Ventura Carla Aparecida Arena
Published: February 2020

Identificar, analisar e sintetizar evidências científicas sobre a relação entre o estigma existente nos serviços de saúde no que se refere aos usuários de álcool e drogas ilícitas e o auto-estigma destes usuários. Método: revisão integrativa da literatura, através de cinco etapas distintas. Resultados: do total de artigos encontrados nas bases de dados, 07 foram selecionados e analisados, resultando nas categorias “O estigma público nos serviços de saúde” e “A relação entre o estigma nos serviços de saúde e o auto-estigma em usuários de álcool e drogas ilícitas”. Conclusão: o auto-estigma é influenciado pelo estigma público propagado, principalmente, por autoridades e por profissionais de saúde. Uma das alternativas para atenuar o cenário do auto-estigma é o apoio social.
Identificação do consumo de substâncias psicoativas entre indivíduos com esquizofrenia
Authors: Contin Mayara Rodrigues , Corradi-Webster Clarissa Mendonça , Vieira Fernanda De Sousa , Zanetti Ana Carolina Guidorizzi
Published: February 2020

Este estudo teve por objetivo identificar o consumo problemático de substâncias em uma amostra de 45 pessoas diagnosticadas com esquizofrenia, tratadas em Centro de Atenção Psicossocial II, e verificar a associação desse consumo a características sociodemográficas e clínicas dos participantes. Estudo transversal. Foram aplicados questionários sobre as substâncias mais consumidas ao longo da vida: tabaco (67%), álcool (73%) e maconha (22%). Dos participantes, 62% faziam uso problemático de pelo menos uma droga. Encontrou-se associação entre uso problemático de substâncias e satisfação financeira, impulsividade e experiências de discriminação. Conhecer as características relacionadas ao uso de drogas entre pessoas em tratamento para esquizofrenia auxilia a propor estratégias de cuidado para essa população.
Atitudes de estudantes iniciantes da graduação em enfermagem diante do paciente alcoolista
Authors: Rodrigues Samuel Barroso , De Souza Jacqueline
Published: February 2020

Objetivo: analisar as atitudes de alunos iniciantes do curso de graduação em enfermagem diante do alcoolista. Método: estudo quanti-qualitativo, no qual foi aplicada a Escala de Atitudes Frente ao Álcool e ao Alcoolista, um questionário sociodemográfico e realizada uma simulação realística. Resultados: as atitudes foram mais positivas e houve associação significativa entre a atitude e a faixa etária (p = 0,014). Identificaram-se três categorias: 1) Aspectos de âmbito comportamental; 2) Aspectos de âmbito conceitual; e 3) Aspectos de âmbito emocional. Conclusão: é importante conhecer as atitudes dos estudantes diante do alcoolista por meio de abordagens também qualitativas a fim de que as práticas educacionais lhes assegurem um preparo mais adequado no cuidado prestado a essa clientela.
Efeitos do consumo de drogas parental no desenvolvimento e saúde mental da criança
Authors: Campelo Lany Leide de Castro Rocha , Santos Raionara Cristina de Araujo , Angelo Margareth , Nóbrega Maria Do Perpétuo Socorro de Sousa
Published: February 2020

Objetivo: analisar as publicações que abordam o impacto do consumo de drogas parental no desenvolvimento e na saúde mental das crianças. Método: revisão integrativa na Biblioteca Virtual em Saúde e no PUBMED, utilizando-se os descritores “Child development”, “Mental health”, “Parents”, “Mothers”, “Drug users” e “Child”. Resultados: a amostra final totalizou 11 artigos sobre efeitos neonatais do consumo de drogas em gestantes e consequências do uso de drogas no desenvolvimento cognitivo, motor e psicossocial das crianças. Conclusão: o consumo de drogas parental compromete o crescimento e o desenvolvimento da criança, podendo ocasionar problemas comportamentais e de saúde mental, seja pelas consequências diretas ou pelos efeitos indiretos do consumo dessas substâncias na criança.
Criatividade S.A.
Authors: Bezerra Camila Paschoal
Published: February 2020

Este livro inventivo ilustra a fascinante narrativa contemplando detalhes sobre como a Pixar nasceu. Escrito por Ed Catmull, co fundador da Pixar Animation Studios e presidente da Pixar Animation e da Disney Animation, este livro permite aos leitores navegarem uma bonita jornada rumo à criatividade, comunicação e gestão.Esta narrativa única contém múltiplos exemplos sobre como a inovação pode ser gerenciada através de diversas metodologias e métricas.Certamente é uma excelente leitura que irá deliciar os entusiastas do entretenimento assim como especialistas em comunicação.
Identificação e ativação de circuitos comunicacionais como estratégia de relacionamento entre marcas e seus stakeholders
Authors: Carvalho Eric De
Published: February 2020

O artigo propõe uma estratégia de inovação no relacionamento entre marcas e seus stakeholders por meio de um protocolo de identificação e ativação de circuitos comunicacionais entre as organizações e seus públicos. A construção desse protocolo considera a teoria das mediações em diálogo com a perspectiva da midiatização, propondo uma metodologia que orienta estudos de mercado que alinham valores de marca com matrizes culturais de seus públicos.
Nova relação entre ser humano e máquina computacional
Authors: Lima Junior Walter Teixeira
Published: February 2020

A comunicação social adota inovações tecnológicas desde o surgimento e popularização das redes telemáticas, que modificaram a forma como a audiência se relaciona nas plataformas digitais conectadas. Nesse ambiente comunicacional, em contraponto a um sistema embasado na relação implementada computacionalmente via master-slave (relação informativa assimétrica), um novo patamar do relacionamento entre ser humano e máquina computacional está sendo modelado pela introdução de sistemas computacionais dotados de arquitetura cognitiva, ou seja, capazes de interação com o ser humano, de forma cognitiva.
From ‘Fetish’ to ‘Aura’: The Charisma of Objects?
Authors: Radermacher Martin
Published: February 2020

In the history of religions, material artifacts have often played an important role as mediations of the ‘sacred.’ They were and are worshipped, venerated, and sometimes destroyed for their assumed supernatural powers. The article reviews theoretical concepts that engage with the charismatic capacities of objects (‘fetish,’ ‘cultic image,’ and ‘aura’) and discusses literature about ‘charismatic objects.’ It deals with the question of what kind of charisma objects may have and suggests that the term ‘charisma,’ when defined in a specific way, is a useful concept to describe and compare specific material objects from different religious traditions. These conceptual and methodological considerations are illustrated by a brief discussion of Christian relic veneration.
Range extension of the Bengal monitor (Varanus bengalensis) for the Trans-Himalayan Region with an altitude record for monitor lizards
Authors: SINGH ASHUTOSH , RANA BHUPINDER SINGH , THAKUR MUKESH , TRIPATHY BASUDEV , SHARMA LALIT KUMAR , CHANDRA KAILASH
Published: February 2020

The Bengal monitor lizard or Common Indian monitor lizard (Varanus bengalensis Daudin, 1802) is classified as Least Concern under the IUCN and listed under the Schedule-I of the Indian Wildlife Protection Act 1972. Further, the trade of the species is prohibited as the species is listed in Appendix I of CITES. It is widely distributed over Western Asia, the Indian Subcontinent, and Southeast Asia (Koch et al. 2013). It is reported to occupy both terrestrial as well as freshwater habitats from desert areas to floodplains, scrubland to forests, in different types of terrains at elevations below 1500m (Auffenberg 1994; Papenfuss et al. 2010). Body size of individuals varies from 61 to 175 cm from the tip of the snout to the end of the tail (Auffenberg 1994; Losos and Greene, 1998). Adults are generally grey or greenish-grey in color, with a ventral pattern of grey to black crossbars from the chin to the tail. Adult individuals are less contrasting and have a less distinct pattern than younger individuals. The species shows a sexual dimorphism, with males being heavier (around 7.18 to 10 kg) than females which are about 40% smaller in size (Papenfuss et al. 2010).
Description of a new species of Dascillus Latreille from Henan, China (Coleoptera: Dascillidae)
Authors: FANG YAN , YAN YIJIE , JIN ZHENYU
Published: February 2020

Dascillus Latreille, 1797 (Coleoptera: Dascillidae) currently contains about 40 species, of which 32 have been reported from China (Jin et al. 2013, 2018; Hájek 2016; Terzani et al. 2017; Wang et al. 2019). The Baotianman National Nature Reserve of Henan (33°20ʹ–33°36ʹN, 111°47ʹ–112°04ʹE) which is one of the “world biosphere reserves” recognized by United Nations Educational, Scientific and Cultural Organization for their high ecosystem and species diversity (Zhu et al. 2002). While examining specimens collected from the survey of the Baotianman National Nature Reserve in 2017, conducted by the Hunan Agricultural University (Changsha, China), a new species of Dascillus was identified and is described in this paper.
Description of Bradyetes paramatthei sp. nov. (Copepoda: Calanoida), a new aetideid species from the deep Pacific Ocean with notes on the genus Bradyetes
Authors: MARKHASEVA ELENA L. , PETROV ANATOLY , RENZ JASMIN
Published: February 2020

A new and rare aetideid species of the benthopelagic genus Bradyetes Farran, 1905 is described from female specimens collected near the seafloor from the abyss of the Pacific, Atlantic and Southern Oceans between 2000 and 2014. The new species, Bradyetes paramatthei sp. nov., is described from the Kurile-Kamchatka Trench (Pacific Ocean) and is additionally reported from the Angola and Guinea basins and from the Meteor Seamount of the Atlantic Ocean. Bradyetes paramatthei sp. nov. is related to the species B. matthei Johannessen, 1976, but differs in the shape of the prosome posterior corners, which are oval-rounded, and in the proximal segment of the antennal exopod, which is supplied with one seta. These two species are shown to constitute a separate species group within the genus Bradyetes. The other species group contains the remaining congeners including Bradyetes inermis Farran, 1905, for which morphological variability is discussed. Specimens of this species show diverse morphology and comprise 3 morphotypes distinguished by the P1, with a developed or absent lateral lobe , the P1 basal medial seta, which is either nude or supplied with setules, and by the different number of setae of the maxillule praecoxal arthrite.
Three new ghost moths of the genus Oxycanus Walker, 1856 from Australia (Lepidoptera: Hepialidae)
Authors: BEAVER ETHAN P. , MOORE MICHAEL D. , VELASCO-CASTRILLÓN ALEJANDRO , STEVENS MARK I.
Published: February 2020

Three new species of ghost moth, Oxycanus ephemerous sp. nov., O. flavoplumosus sp. nov., and O. petalous sp. nov. are described from South Australia, New South Wales, and south-west Western Australia, respectively. We illustrate these species and compare morphological and molecular (mtDNA COI gene) characters with similar Oxycanus Walker, 1856 species from Australia. Comparative images of Oxycanus subvaria (Walker, 1856), O. byrsa (Pfitzner, 1933), and O. determinata (Walker, 1856) are figured. The type material of the three new species are held in the Australian National Insect Collection, Canberra, the Western Australian Museum, Perth, and in the South Australian Museum, Adelaide. The type specimens of Oxycanus hildae Tindale, 1964 syn. n. were also examined and the taxon is here considered synonymous with O. subvaria. Concerns are raised about the conservation status of all three new species due to few or localised distribution records.
Another new Cyrtodactylus (Squamata: Gekkonidae) from Guwahati, Assam, India
Authors: PURKAYASTHA JAYADITYA , DAS MADHURIMA , BOHRA SANATH CHANDRA , BAUER AARON M. , AGARWAL ISHAN
Published: February 2020

We describe a new species of Cyrtodactylus from Guwahati city in the state of Assam, India and provide additional data on the recently described Cyrtodactylus guwahatiensis. Cyrtodactylus urbanus sp. nov. falls in the newly defined khasiensis group within the Indo-Burma clade of Cyrtodactylus and is the poorly supported sister taxon to Cyrtodactylus khasiensis. The new species differs from other members of the khasiensis group in mitochondrial sequence data (12.5–17.1 % uncorrected pairwise ND2 sequence divergence) as well as aspects of morphology including the number and arrangement of precloacal pores in males, the number of mid-ventral scales and paravertebral tubercles, and colour pattern. This is the second Cyrtodactylus endemic to the Guwahati region, the fourth from Assam and the twelfth from Northeast India.
Osteological evidence for monophyly of the Leiognathidae (Teleostei: Acanthomorpha: Acanthuriformes)
Authors: GILL ANTHONY C. , MICHALSKI STEFFI
Published: February 2020

Osteological characters supporting monophyly and identification of extant Leiognathidae are reviewed. Ten osteological synapomorphies support monophyly of the Leiognathidae, involving modification of the ribs, gill arches, palatoquadrate, median fins and branchiostegals. Fourteen additional characters are noted that nest the Leiognathidae within the Acanthuriformes (sensu Gill & Leis). Nine further characters are noted as useful for identification of leiognathids, though each occurs more widely among acanthuriforms and other fishes. Three fossil genera that have been assigned to the Leiognathidae are briefly reviewed for the various leiognathid characters. Only one fossil genus, †Euleiognathus Yabumoto & Uyeno, appears correctly placed in the family.
Morphological Redescriptions and Molecular Phylogeny of Three Stentor Species (Ciliophora: Heterotrichea: Stentoridae) from Korea
Authors: TAHER MD ABU , KABIR AHMED SALAHUDDIN , SHAZIB SHAHED UDDIN AHMED , KIM MIN SEOK , SHIN MANN KYOON
Published: February 2020

The morphologies of the three freshwater stentorid ciliates in Korea, Stentor coeruleus (Pallas, 1766); Stentor muelleri Ehrenberg, 1831, and Stentor tartari Murthy & Bai, 1974, were investigated based on live observations and protargol impregnation. The Korean population of S. tartari exhibits the following characteristics: body size 200–355 × 85–135 µm in vivo, 62–106 somatic kineties, 8–13 peristomial kineties, 110–180 adoral membranelles, mostly two macronuclear nodules and 5–18 micronuclei, reddish and colorless cortical granules and the presence of symbiotic algae. We identified S. tartari based on unique characteristics compared to close congeners. Korean populations of S. coeruleus and S. muelleri are congruent with previously described populations in most aspects of their morphologies. Here, for the first time, we report molecular gene sequence information for S. tartari. Small subunit (SSU) rRNA gene sequence-based phylogeny indicates that S. tartari, which has multiple macronuclei, forms a monophyletic group with other Stentor species having a single macronucleus. Our findings based on morphology and SSU rRNA gene sequence information corroborate the hypothesis that the elongated macronucleus evolved from the compact single or multi macronucleus state.
Notes on the tribe Petrognathini Blanchard, 1845 from China, with description of a new species from Yunnan (Coleoptera, Cerambycidae, Lamiinae)
Authors: BI WEN-XUAN , CHEN CHANG-CHIN , LIN MEI-YING
Published: February 2020

Ithocritus ruber (Hope, 1839), the type species of the genus Ithocritus Lacordaire, 1872 is reinvestigated, and a partially sympatric species, Ithocritus similis Bi & Lin, sp. nov. (相似短柄天牛, Xiāng sì duǎn bǐng tiān niú), is described. The genus Falsimalmus Breuning, 1956 is newly recorded from China, based on the discovery of Falsimalmus niger Breuning, 1956 from Yunnan. New localities, illustrations of habitus, endophallic structure and major diagnostic features for all involved taxa are provided.
Dermaptera (Insecta): a guide for hind wing stretching and hind wing preservation
Authors: HELEODORO RAPHAEL AQUINO , RAFAEL JOSÉ ALBERTINO
Published: February 2020

The Dermaptera (earwigs) have the most complex folding system of the posterior wing among insects. We provide an illustrated guide describing how to stretch a dermapteran hind wing and mount it on slides in Hoyer’s medium.
Ultrasound-Based Mechanical Adaptation of Achilles Tendon After 12-Week Running with Minimalist Shoes
Authors: Zhang Xini , Luo Zhen , Wang Junqing , Yang Yang , Fu Weijie
Published: February 2020

This study aimed to investigate the effect of a 12-week running program using minimalist shoes on ultrasoundbased mechanical adaptation of Achilles tendon (AT). Fifteen male recreational runners accustomed to run in standard cushioned shoes with rearfoot strike pattern were recruited.
They were required to wear minimalist shoes without a compulsory transition in foot strike pattern, and be involved in a 12-week running program. Before and after the intervention, the cross-sectional area of AT was collected in the prone position via an ultrasound device. The ankle plantarflexion
moment, recorded on an isokinetic dynamometer, was synchronized to the image changes in vivo AT length. Intraclass correlation coefficient was determined to evaluate the intraand interobserver variabilities. Paired t-test was used to quantify the effects of training program (pre-
and posttraining) on each variable of the cross-sectional area, AT force, AT stress, and AT strain during an isometric contraction. Seven participants dropped out after the intervention. The results showed that the intraclass correlation coefficients for the intra- and interobserver reliabilities
were good to excellent (intraclass correlation coefficients = 0.895–0.996) for the cross-sectional area and elongation. After 12-week running with minimalist shoes, plantarflexion moment, AT force, AT stress, and AT strain significantly increased during an isometric contraction (P
< 0.05). The mechanical adaptation of AT improved after 12-week running with minimalist shoes by more efficient energy storage and release, which could prevent or reduce the risk of injury potentially.
Sports Related Injury Mechanism on Ice Hockey Skills: A System Review
Authors: Jiang Xinyan , Song Yang , Sun Dong , Rong Ming , Mao Lijuan , Fekete Gusztav
Published: February 2020

As one of the official sports in the Winter Olympics Games, ice hockey is a competitive team activity combining changeable skating skills with agile hockey skills. The biomechanical studies of different skills used by ice hockey players are considered to be effective ways to improve
performance and reduce injury risks. The purpose of this study was to conduct a review that elucidated the biomechanical research about those techniques. Englishlanguage literature searches of the electronic databases in Google Scholar, Web of Science, and ScienceDirect were performed from
1999 to June 2019, using the following key words: ‘Biomechanics’ AND ‘Ice hockey player’ OR ‘Ice hockey athlete.’ Of the 455 identified articles, 17 studies met the inclusion criteria and were included in this review. Most of the studies were conducted by
Canadians and it is consistent with the country’s dominant position in ice hockey competitions. Forward skating, skating start, and shooting were the most studied skills in order to optimize sports performance and reduce injury risks. Players with different levels or sex would exhibit
different biomechanical characteristics during forward skating and skating start, and those characteristics may also alter with each stride. In addition, several factors, including the players and sticks’ characteristics, may be associated with the shot accuracy. While ice hockey is
always considered as a high-risk sport, little biomechanical studies have been conducted to explore the injury mechanisms and preventions of specific ice hockey techniques. Future research on the biomechanical analysis of ice hockey players’ skills, especially the injuries during some
specific ice hockey skills, is much needed.
Deep Learning Approach Applied to Prediction of Bone Age Based on Computed Tomography Orthopedic Image Processing
Authors: Tan Gefei , Wang Daoshun
Published: February 2020

Objective: Deep learning and neural network models are new research directions in the field of machine learning and artificial intelligence. Deep learning has made breakthroughs in image recognition and speech recognition applications, and has also shown unique advantages in
face recognition and information retrieval, and has been widely used. Methods: Thin-layer computed tomography (CT) scan and multiplanar reconstruction (MPR) and volume reconstruction (VR) techniques were used to perform CT thin-slice scan and volume of the bilateral clavicle sternum
at 548 number of l5~25 years old. Reproduction (volume rendering, VR) and three-dimensional image recombination, measuring and calculating the longest diameter of the sternal end of the bilateral clavicle, the longest diameter of the metaphysis and its length ratio, the area of the epiphysis,
the area of the metaphysis and its area ratio, etc. We establish a mathematical model of bone age inference, and then substitute 50 training samples into the mathematical model to test the accuracy of the model. Results: There was a statistically significant difference between the male
and female sex ratios in the same age group (P < 0.05). The established mathematical model shows that the developmental law of the sternal skeletal bone is highly correlated with the biological age. The accuracy of all models is 70.5% (±1.0 years old) and 82.5% (±1.5
years). Skeletal X-ray images show different gradation changes in black and white, with black-and-white contrast and hierarchical image features. Based on the advantages of deep learning in image recognition, we combine it with bone age assessment research to build a forensic bone age automation.
Conclusions: This paper harnesses the basic concepts of deep learning and its network structure, and expounds the research progress of deep learning in image recognition in different research fields at home and abroad in recent years, as well as the advantages and application prospects
of deep learning in bone age assessment.
Rational Design of Co3O4 Nano-Flowers for High Performance Supercapacitors
Authors: Li Yucai , Zhao Yan , Zhang Dong , Song Shiwei , Wang Jian , Ke Yunjie
Published: February 2020

Electrochemical performance of the electrode materials is seriously dependent on the structure and morphology of the electrode material. In this work, the nanoflower-like Co3O4 samples are successfully prepared on Ni foam via a facile hydrothermal method. The as-fabricated
Co3O4 samples exhibit superior electrochemical performance with a high specific capacitance of 382.6 C g-1 at 1 A g-1 and excellent capacitance retention. In addition, the as-fabricated device presents a high energy density of 23.6 Wh kg-1
at a power density of 508.6 W kg-1 and excellent cycle stability with a capacitance retention of 81.2% after 10000 cycles, indicating a promising application as electrodes for energy storage device.
NEED: The Northern European Enclosure Dam for if Climate Change Mitigation Fails
Authors: Groeskamp Sjoerd , Kjellsson Joakim
Published: February 2020

It might be impossible to truly fathom the magnitude of the threat that global-mean sea level rise poses. However, conceptualizing the scale of the solutions required to protect ourselves against global-mean sea level rise aids in our ability to acknowledge and understand that threat. On these grounds, we here discuss a means to protect over 25 million people and important economical regions in northern Europe against sea level rise. We propose the construction of a Northern European Enclosure Dam (NEED) that stretches between France, the United Kingdom, and Norway. NEED may seem an overwhelming and unrealistic solution at first. However, our preliminary study suggests that NEED is potentially favorable financially, but also in scale, impacts, and challenges compared to that of alternative solutions, such as (managed) migrations and that of country-by-country protection efforts. The mere realization that a solution as considerable as NEED might be a viable and cost-effective protection measure is illustrative of the extraordinary global threat of global-mean sea level rise that we are facing. As such, the concept of constructing NEED showcases the extent of protection efforts that are required if mitigation efforts fail to limit sea level rise.
Forecasting the Past: Views of Earth from the Moon and Beyond
Authors: Lopez Philippe
Published: February 2020

As we celebrate the fiftieth anniversary of NASA’s Apollo missions, images of Earth simulated with the ECMWF Integrated Forecasting System (IFS) are visually compared with pictures collected during space missions of the past five decades, in particular from the Apollo missions (1968–72). The numerical weather reforecasts use the latest version of the IFS and are initialized from (re)analysis data, which provide our current best representation of the atmospheric state for any given date back to the 1950s. Visible images of our planet are produced from the IFS with a simple simulator whose main inputs are the solar fluxes at the top of the atmosphere. First, a comparison to recent imagery from deep space illustrates the high level of performance of the IFS on recent dates. Then, the validation of the IFS against photographs taken by Apollo 11 and 17 both in-flight and from the lunar surface exhibits a significant level of agreement, despite the absence or very limited number of satellite observations available. This short study confirms that the combination of high-quality initial conditions with a modern numerical weather prediction model can yield reasonably accurate reforecasts of global meteorological conditions, especially cloud systems, for dates as far back as the late 1960s.