bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategies for Successful Survivorship Care Plan Implementation: Results From a Qualitative Study
Authors: Birken Sarah A. , Clary Alecia S. , Bernstein Shampa , Bolton Jamiyla , Tardif-Douglin Miriam , Mayer Deborah K. , Deal Allison M. , Jacobs Sara R.
Published: July 2018

Introduction:

Care for US cancer survivors is often fragmented, contributing to poor health outcomes. Care and outcomes may improve when survivors and follow-up care providers receive survivorship care plans (SCPs), written documents containing information regarding cancer diagnosis, treatment, surveillance plans, and health promotion. However, implementing SCPs is challenging. As such, we sought to identify strategies for successfully implementing SCPs.

Methods:

We measured SCP implementation using performance data from cancer programs participating in the American Society of Clinical Oncology Quality Oncology Practice Initiative, an oncologist-led quality assessment and improvement program. We used semistructured interviews with cancer program employees (eg, physicians) to identify strategies for successfully implementing SCPs by comparing approaches in cancer programs that, according to Quality Oncology Practice Initiative performance indicators, developed and delivered SCPs to a relatively small proportion of eligible survivors and their follow-up care providers (ie, low performers; n = 6 participants in five programs) with approaches among programs with better performance (ie, moderate performers; n = 15 participants in nine programs).

Results:

Ten of 14 cancer programs developed SCPs for ≥ 50% of eligible survivors; two of 14 delivered SCPs to any survivors; and eight of 14 delivered SCPs to ≥ 25% of follow-up care providers. We found that moderate performers proactively addressed SCP requirements, leveraged requirements to improve survivorship care, set internal targets, automated implementation, had active leaders and champions, and tasked appropriate employees with SCP implementation.

Conclusion:

SCP implementation remains challenging. We identified strategies for successfully implementing SCPs. Future research should examine how cancer programs have achieved these strategies; findings could contribute to an understanding of the changes needed to implement comprehensive survivorship care.
Electricity: How Much for the Contemporary Tertiary Care Operating Room? A Case Report
Authors: Shamir Micha Y. , Weissman Charles
Published: July 2018

Surgery requires many electrically driven devices. Three events occurred recently in an operating room (OR) suite circa the 1980s wherein circuit breakers tripped due to overloaded circuits. This led to us to (1) increase OR electric capacity; (2) record each instrument’s power requirements, map their OR location, and determine when during surgery they were used; (3) provide users with instruction and diagrams into which outlet to plug each instrument. When introducing surgeries requiring devices, especially with high electrical power (current or amperage) demands, or renovating older or planning new ORs, it is important to provide ORs with sufficient electric current, circuits, and outlets.
Presidential Address: Eighteenth-Century Indian Trading Villages in the Wabash River Valley
Authors: Sleeper-Smith Susan
Published: July 2018

In the eighteenth-century western Great Lakes, the French and British established forts to guard a highly profitable fur trade. Places like Fort Michilimackinac became synonymous with the fur trade. In warmer regions an equally profitable Indian-controlled fur trade also took place. This article examines the Wabash River valley trade and shows how two Indian villages, Kethtippecanuck and Miamitown, dominated the exchange process. Economics and sociability were intertwined in this flourishing region. Trade took place between friends and relatives, defined by the reciprocity embedded in the kin networks of Indian women. Indian women processed the furs, which allowed them to exert pressure on the exchange process, transforming the fur trade into the cloth trade. Women’s access to trade goods enhanced their authority, and their access to cloth led to a flowering of Indian clothing styles, situating them at the heart of a highly prosperous fur trade.
Threads, Traces, and the Affective Foundation of a Region: The Case Study of the Slate Falls First Nation (Canada)
Authors: Oliveira Frederico
Published: July 2018

For many generations, the seasonal mobility pattern over the territory has been an important factor defining family relations and land-use systems for the northern Anishinabeg in Canada. Using the case study of Slate Falls First Nation, this article, going beyond ecologically and economic-driven explanatory models, integrates history and indigenous perceptions of the environment as powerful instruments to record the people’s knowledge of the land and to assert self-determination. The emphasis is placed on people’s daily itineraries and cyclical practices with their ancestral territory, by using their year-round activities as the guiding temporal framework to connect their current lives with the old process of creating and maintaining a region that became their homeland.
Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells
Authors: Ghosh Somadri , Scozzaro Samuel , Ramos Ana Raquel , Delcambre Sébastien , Chevalier Clément , Krejci Pavel , Erneux Christophe
Published: July 2018

Metastasis of breast cancer cells to distant organs is responsible for ∼50% of breast cancer-related deaths in women worldwide. SHIP2 (also known as INPPL1) is a phosphoinositide 5-phosphatase for phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2]. Here we show, through depletion of SHIP2 in triple negative MDA-MB-231 cells and the use of SHIP2 inhibitors, that cell migration appears to be positively controlled by SHIP2. The effect of SHIP2 on migration, as observed in MDA-MB-231 cells, appears to be mediated by PI(3,4)P2. Adhesion on fibronectin is always increased in SHIP2-depleted cells. Apoptosis measured in MDA-MB-231 cells is also increased in SHIP2-depleted cells as compared to control cells. In xenograft mice, SHIP2-depleted MDA-MB-231 cells form significantly smaller tumors than those formed by control cells and less metastasis is detected in lung sections. Our data reveal a general role for SHIP2 in the control of cell migration in breast cancer cells and a second messenger role for PI(3,4)P2 in the migration mechanism. In MDA-MB-231 cells, SHIP2 has a function in apoptosis in cells incubated in vitro and in mouse tumor-derived cells, which could account for its role on tumor growth determined in vivo.
Cardiorespiratory interactions in the Pacific spiny dogfish,Squalus suckleyi
Authors: Acharya-Patel Neha , Deck Courtney A. , Milsom William K.
Published: July 2018

Elasmobranchs are a group of cartilaginous fish with no direct sympathetic innervation of the heart or gills. Fast cardiorespiratory regulation is controlled solely by the parasympathetic branch of the autonomic nervous system. Cardiovascular changes associated with ventilation are commonly present in the form of respiratory sinus arrhythmia (RSA) and as cardiorespiratory synchrony (CRS in which there is a 1:1 beat to breath ratio). The latter has been hypothesized to maximize oxygen uptake coupling the pulsatile flows of blood and water in the gills. Given this, we hypothesized that CRS should be more prevalent in situations of low oxygen supply and RSA should be abolished by vagotomy. To test this, we investigated the role of the vagus nerve in mediating cardiorespiratory responses to changing environmental oxygen conditions in the elasmobranch; Squalus suckleyi. Hypoxia and hyperoxia had little effect on heart rate but did alter breathing frequency and amplitude. Atropine yielded an overall tachycardia in all oxygen conditions and abolished all heart rate variability (HRV) suggesting that HRV solely reflects fluctuating vagal tonus on the heart. Regardless of the presence of atropine, hypoxia still induced an increase in ventilation rate and depth. CRS was only found during progressive hyperoxia post atropine when heart rate was uninhibited and ventilation was slowed due to the increase in oxygen supply suggesting that in Squalus suckleyi CRS is an epiphenomenon and not actively regulated to maximize gas exchange efficiency.
High resolution isotropic diffusion imaging in post-mortem neonates: a feasibility study
Authors: McDowell Amy R , Shelmerdine Susan C , Carmichael David W , Arthurs Owen J
Published: July 2018

Objective:

To investigate the potential of advanced diffusion weighted imaging (DWI) in post-mortem MRI (PMMR) at 3T.

Methods:

We acquired PMMR brain and body imaging in 12 neonates, mean gestational age 33.4 weeks (range 29–37 weeks) at 3T and 1.5T. Head and body diffusion imaging at 1.5T consisted of bipolar diffusion encoding and single-shot spin-echo echo-planar imaging (SE-EPI) for acquisition (echo time (TE) 96 ms; repetition time (TR) 2700 ms; voxel size 1.8 x 1.8 mm in-plane with slice thickness 5 mm; b-values of 500 and 1000 s/mm2 applied in three orthogonal directions; total acquisition time 2:12). A whole-body 3T diffusion imaging protocol using monopolar diffusion encoding and simultaneous multislice EPI acquisition with gradients applied in 12 uniformly distributed directions was obtained (TE 53.4 ms; TR 5600 ms; 1.8 mm isotropic; multiband factor 2; b-values of 250, 750, 1250 and 1750 s/mm2; acquisition time 2:09 for a single b-value).

Results:

There was significant improvement in image quality in multiband, multislice diffusion PMMR protocol. On visual assessment of image quality, 1.5T DWI scored poorly (mean 2.4 SD ± 0.47), and all 3T b-values individually scored significantly higher (p < 0.001) apart from b = 250 s/mm2 which was not significantly different.

Conclusion:

Recent advances in diffusion sequences and hardware utilising higher field strengths and gradient performance allows whole-body diffusion PMMR imaging at high resolution with improved image quality compared to the current clinical approach.

Advances in knowledge:

We have demonstrated feasibility of a multislice, multiband quantitative diffusion imaging sequence in the perinatal post-mortem setting. This will allow more detailed and quantitative clinical PMMR investigations using diffusion MRI in the future.
Budd-Chiari syndrome: imaging review
Authors: Bansal Varun , Gupta Pankaj , Sinha Saroj , Dhaka Narender , Kalra Naveen , Vijayvergiya Rajesh , Dutta Usha , Kochhar Rakesh
Published: July 2018

Budd-Chiari syndrome (BCS), also known as hepatic venous outflow tract obstruction includes a group of conditions characterized by obstruction to the outflow of blood from the liver secondary to involvement of one or more hepatic veins (HVs), inferior vena cava (IVC) or the right atrium. There are a number of conditions that lead to BCS-ranging from hypercoagulable states to malignancies. In up to 25% patients, no underlying disorder is identified. Diagnosis of BCS is based on a combination of clinical and imaging features. A major part of the literature in BCS has been devoted to interventions; however, a detailed description of various imaging manifestations of BCS is lacking. In this review, we highlight the importance of various imaging modalities in the diagnosis of BCS.
DESENVOLVIMENTO E ACEITAÇÃO SENSORIAL DE KEFIR COM GELEIA DE GOIABA E AVALIAÇÃO DE COMPOSTOS BIOATIVOS
Authors: Cavararo Carollyne Dos Santos , Silva Jr Jorge Pinho , Domingues Josiane Roberto , Chiappini Claudete Corrêa de Jesus
Published: July 2018

Introdução: Compostos bioativos são definidos como nutrientes ou não nutrientes que possuem ação metabólica ou fisiológica específica no organismo, como as ações antitumoral, antifúngica, antibacteriana, imunomoduladora, anti-inflamatória e antioxidante. Os probióticos presentes nos leites fermentados e os carotenoides presentes nas frutas são descritos, na literatura, como benéficos à saúde. Objetivo: Desenvolver, avaliar a aceitação sensorial, a atividade antioxidante e determinados compostos bioativos de kefir com geleia de goiaba. Metodologia: O kefir foi desenvolvido e sua aceitação avaliada pelo teste de escala hedônica; a composição centesimal foi determinada pelos métodos oficiais; a atividade antioxidante foi avaliada pelo ensaio ORAC; os compostos fenólicos totais e os carotenoides totais foram determinados por método espectrofotométrico. Resultados: A adição dos 30% de geleia de goiaba elevou a atividade antioxidante, os compostos fenólicos e os carotenoides totais do kefir. O produto elaborado foi bem aceito pelos consumidores, que também comprariam o produto caso este fosse comercializado. Conclusão: Concluiu-se que adição de geleia contribuiu para o aumento dos compostos bioativos avaliados e a bebida fermentada poderia contribuir para a saúde dos consumidores.DOI: 10.12957/demetra.2018.31290
Violência e agressividade: Diferenças a partir da linguagem e do inominável da feminilidade
Authors: Laia Sérgio , Caldas Heloisa
Published: July 2018

Norteado por referenciais psicanalíticos, este artigo aborda a distinção entre agressividade e violência a partir dos limites da linguagem para se nomear o feminino. São discutidos aspectos da violência em seu estágio atual, tais como: sua escalada, seu deslocamento do espaço privado ao público, suas formas de manifestação nas famílias. Abordando mais especificamente a violência dirigida contra o feminino, investiga-se as condições que a propiciam assim como perspectivas de saída dos embates que ela implica. Um novo modo de abordar o feminino é configurado como uma saída, na medida em que se possa dar um passo adiante das políticas de empoderamento da mulher, mais assentadas na igualdade sexual, e que se possa lidar mais efetivamente com as disparidades subjetivas.
Paying attention to the small things: trace minerals and vitamins impact pregnancy wastage
Authors: Van Saun Robert J
Published: July 2018

Pregnancy wastage resulting from abortion and stillbirth are a confounding problem for practitioners given the low rate of confirmatory diagnosis. The role of nutrition has been implicated in fetal development and postnatal survival yet minimal evidence has been provided to support a diagnostic connection. This clinical review will provide the background to understanding trace mineral and fat-soluble vitamin metabolism during gestation, implications on abortion, stillbirth, and neonatal survival, and opportunities for diagnosis and prevention. Histologic lesions in aborted or stillborn calves consistent with either iodine or selenium deficiency support a direct role of these trace minerals. Comparison of hepatic mineral concentrations in aborted, stillborn, and abattoir calves suggests other trace mineral and vitamin A deficiencies in these losses, but a more definitive cause and effect association is needed. Maternal nutrition during gestation is critical to ensuring adequate trace mineral and vitamin status during fetal development and into early postnatal life.
CattleReview
Authors: Barrett David C
Published: July 2018

Introduction:

This edition of Cattle Review considers recent publications looking at veterinary attitudes to selective dry cow therapy (SDCT) in the Netherlands, the use of milk antibody tests for Ostertagia ostertagi and genomic testing of dairy heifers in grazed systems.
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT
Authors: Nascimento Sâmia Israele Braz do , Santos Sheezara Teles Lira dos , Alves Bárbara Torquato , Aguilera Kevellyn Cruz , Menezes Airton César Pinheiro de , Alencar Ana Maria Correia , Andrade Ana Maria Lima Carneiro de , Leite Daniel Gonçalves , Melo Antonio Marlos Duarte de
Published: July 2018

Since the twentieth century, humanity has been experiencing a public health reality marked by numerous mosquito-borne diseases (belonging to the arthropod class), known as arboviruses. The Zika virus has become in recent years a risk to Brazilian and international public health due to its devastating effect due to its pathogenesis but also to fetal neurological development, causing serious health problems such as microcephaly and Guillain-Barré Syndrome, but also myelitis and meningoencephalitis. However, scientists studying the Zika virus have been trying to use the agent's ability to cause infections in healthy cells to attack and destroy cancer cells, such as the case of grade IV astrocytoma known as Gliobastoma Multiforme (GBM), which is a tumor of the very aggressive central nervous system and worse prognosis among primary cancers. As a result of effective therapy for GBM and the tropism of this etiological agent for brain cells, the hypothesis is that this virus would cause cell death in glioblastomas through metabolic alterations induced by the induced viral infection, but further studies must be carried out to demonstrate this therapeutic advantage in using the virus for the treatment of this malignant disease. Keywords: Zika virus; Gliobastoma Multiforme; Tumor of the Central Nervous System.
THE INNOVATIONS, ADVANCES AND OUTLOOKS OF LIQUID BIOPSY IN ONCOLOGY: A LITERATURE REVIEW
Authors: Melo Antonio Marlos Duarte de , Silva Filho Messias Silvano Da , Alves Bárbara Torquato , Aguilera Kevellyn Cruz , Alencar Ana Maria Correia , Andrade Ana Maria Lima Carneiro de , Leite Daniel Gonçalves , Quidute Ricardo Souto
Published: July 2018

Studies on the biology of cancer are multiplying and have been giving significant repercussions on the care of cancer patients, and there is a growing need to evaluate the biology of the tumor. Conventional tissue biopsies currently represent the gold standard in the diagnosis of cancer, but they are not suitable for serial analysis because of the need for invasive procedures, besides being able to present a high risk of life and also impossibility of reaching surgical in some tumors. To solve this obstacle, the use of the Liquid Biopsy, which analyzes the presence of biomarkers released by cancer cells, such as circulating tumor cells (CTCs), tumor cell DNA (ctDNA) and exosomes is being discussed. These techniques are non-invasive or minimally invasive and collect their samples from peripheral blood, plasma and serum, urine, saliva and cerebrospinal fluid (CSF). As they are already being used in the treatment of several histopathological types of cancer, these new techniques generally represent a revolution in the understanding of early diagnosis, choice of personalized treatment, follow-up of the treatment response in real time, detection of minimal residual disease and prognosis for malignant neoplasms. The objective of this study was to present a literature review to clarify the fundamental molecular and clinical aspects involved in this revolutionary diagnostic technique by extracting the data from the sample. Keywords: Liquid Biopsy. Oncology.: literature review
Modern Dilbilime Göre Nahiv Terimlerinin Delaleti
Authors: ELSHAHHAT ABDELHAMİT SHOEİR Mohamed Rızk
Published: July 2018

“Mustalah” (terim) kelimesi, “anlaşmak, uzlaşmak” anlamına gelmektedir. Zira “mustalah” (terim), bir ilmî disiplin mensuplarının, belirli bir bilimsel kavramı ifade etmek için kullandıkları kelime üzerindeki uzlaşımına delalet eder. Terimler, el-Hârizmî’nin ifadesiyle, bilimlerin anahtarlarıdır. Bunun yanı sıra “Terimleri anlamak, ilmin yarısıdır.” denilmiştir. Çünkü terim, bir kavrama delalet eden lafızdır; bilgi de, birbiriyle sistematik şekilde irtibatlı kavramlardan oluşmaktadır. Terimbilim ile dilbilim arasında sıkı bir bağ vardır: Terimbilim, uygulamalı dilbilimin kapsamına girmekte olup ikisi arasındaki ilişki âmm-hâss ilişkisidir. Terimbilim, kavramların net bir şekilde tanımlanmasından sonra başlar. Terimbilim, kelime üzerine araştırma yapmak ile sınırlı olup kavramlara delalet eden terimlere –ki terimler de bu kavramları ifade etmeye yarar- ağırlık verir. Dilbilim ise, kelimelerin yanı sıra cümle yapısı, ses gibi birçok farklı alanı inceler.Terimbilim, terimlerin belirli alanlarda sunumunu gerektirir. Ayrıca bir alanın terimleri, fikrî bir temele göre birbiri ardına gelir/art arda gelir. Bu yönüyle terimbilim, anlam sahalarına göre kelimelerin sunulması temeline dayalı sözlükçülük yaklaşımlarıyla ortaklık gösterir. Arap mirasında, kelimelerin konularına göre sınıflandırılması fikrine yönelik çok sayıda uygulama bulunmaktadır. Sözlük yazımının bu türünün en meşhur örneği İbn Sîde’nin “el-Muhassas” adlı sözlüğüdür. Dilbilim de –en azından- aynı dilde birçok dilbilim terimleri sözlüğünün olduğu bir ortamda terimlerin ortak olması/standartlaşması açısından terimbilime ihtiyaç duyduğu gibi dilbilim temellerinin oturduğu teknik ve dilsel esasları açıklamak için terimbilimin verilerine ihtiyaç duyar. Makale PlanıNahiv terimleri, eski ya da yeni dilbilim çalışmalarında büyük bir yekün teşkil etmektedir. Bundan dolayı, nahiv terimleri için –asgari olarak temel noktaları karşılayacak şekilde- özel bir sözlüğe ihtiyaç vardır. Ancak çalışmamız, en meşhur ve en yaygın terimlerle sınırlı olup bir giriş ve üç bölümden oluşmaktadır. Her bölüm, aşağıda olduğu üzere bazı terimleri kapsamaktadır. Birinci Bölüm: Cümle yapısı ve cümlenin anlamına dair terimler: Dil, olay, sözdizim düzeyi, nazm, nahvî delalet, fonksiyonel delalet, irab, mana ve nahvî zaman terimleri ele alınmaktadır. İkinci Bölüm: Dilbilgisi kuralları ve anlam ile olan ilişkisine dair terimler: Nahiv, gramatikal sistem, cümle, kelime grubu (et-terkib en-nahvî), âmil, nesh ve mefuller terimleri ele alınmaktadır. Üçüncü Bölüm: Nahiv ve anlam açısından “isnad” terimi: İsnad, müsned, müsned ileyh, umde ve fadle terimleri ele alınmaktadır.
Kadar High Density Lipoprotein (HDL) Telur Puyuh Jepang (Coturnix japonica L.) setelah Pemberian Tepung Kunyit (Curcuma longa L.) pada Pakan
Authors: Zulhaidar Muhammad Hisyam , Saraswati Tyas Rini , Tana Silvana
Published: July 2018

Telur puyuh memiliki kandungan gizi yang cukup tinggi dibandingkan dengan jenis telur yang lain, namun kadar High Density Lipoprotein (HDL) di dalamnya tergolong rendah. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis kadar HDL telur puyuh Jepang (Coturnix coturnix japonica L.) yang diproduksi setelah pemberian suplemen serbuk kunyit dalam pakan sebelum masak kelamin. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 15 ekor puyuh betina yang dibagi ke dalam 3 kelompok perlakuan dengan 5 kali ulangan. P0: kontrol. P1: kelompok perlakuan yang diberi suplemen serbuk kunyit dengan dosis 54 mg/ekor/hari. P2: kelompok perlakuan yang diberi suplemen serbuk kunyit dengan dosis 108 mg/ekor/hari. Perlakuan dimulai saat puyuh berusia 14 hari dan berlangsung selama 30 hari. Parameter yang diamati adalah kadar HDL telur puyuh, bobot kuning telur, dan konsumsi pakan. Data yang diperoleh dianalisis menggunakan Analysis of Variance (ANOVA) dan dilanjutkan dengan uji Duncan pada taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa pemberian suplemen serbuk kunyit dengan dosis 108 mg/ekor/hari terhadap kadar HDL telur puyuh kontrol (P0) dan P1 menunjukan hasil yang berbeda nyata, namun berbeda tidak nyata terhadap konsumsi pakan, dan bobot kuning telur. Kesimpulan penelitian ini adalah pemberian suplemen serbuk kunyit dengan dosis 108 mg/ekor/hari dapat meningkatkan kadar HDL yang terkandung di dalam telur puyuh jepang. Kata kunci : HDL, kuning telur, puyuh jepang (Coturnix coturnix japonica L.), serbuk kunyit (Curcuma longa L.)
Pengaruh Pupuk Nanosilika Terhadap Jumlah Stomata, Kandungan Klorofil dan Pertumbuhan Padi Hitam (Oryza sativa L. cv. japonica)
Authors: Putri Fevi Mawadhah , Suedy Sri Widodo Agung , Darmanti Sri
Published: July 2018

Tanaman padi membutuhkan silika lebih banyak dari pada tanaman lainnya, sementara lahan pertanian di Indonesia banyak yang mengalami leaching unsur hara mikro termasuk Si.Unsur hara Si untuk tanaman padi selama ini hanya didapat dari keberadaannya di lahan sawah dan tidak dilakukan penambahan dari luar, hal ini menyebabkan ketersediaan Si akan terus berkurang dari waktu ke waktu, untuk mengatasi hal tersebut perlu dilakukan pemupukan silika. Penggunaaan pupuk silika dalam bentuk nano lebih menguntungkan bagi tanaman karena lebih reaktif, distribusi lebih merata dan langsung mencapai target, serta hanya dibutuhkan dalam jumlah sedikit. Penelitian ini bertujuan menganalisis pengaruh pemberian pupuk nanosilika terhadap jumlah stomata,kandungan klorofil dan pertumbuhan padi hitam (Oryza sativa L. cv.  Japonica). Penelitian ini dilakukan menggunakan Rancangan Acak Lengkap (RAL) satu faktor, yaitu konsentasi pupuk nanosilika dengan lima taraf perlakuan:0 ml/L; 2,5 ml/L; 5 ml/L; 7,5 ml/L; 10 ml/L.Data yang diperoleh dianalisis menggunakanAnalisys of Variance (ANOVA) dan dilanjutkan dengan uji jarak berganda Duncan’s Multiple Range Test(DMRT) pada taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa pemberian pupuk nanosilika dengan konsentrasi 7,5 ml/L dapat meningkatkan pertumbuhan yaitu; jumlah stomata sebesar 142 %, tinggi tanaman sebesar 33% dan tebal daun sebesar 100% dibandingkan kontrol. Namun pemberian pupuk nanosilika tidak berpengaruh nyata terhadap jumlah anakan, bobot basah, bobot kering dan kandungan klorofil. Kata kunci: beras hitam, nanosilika, pertumbuhan, stomata, klorofil
Peran Cahaya bagi Kehidupan Unggas: Respons Pertumbuhan dan Reproduksi
Authors: Kasiyati Kasiyati
Published: July 2018

Aves merupakan hewan model terbaik yang memberikan respons dengan adanya paparan cahaya artifisial. Pemanfaatan cahaya pada budi daya unggas telah lama diterapkan karena memiliki beragam keuntungan. Cahaya memiliki fungsi penting untuk mengatur ritme harian, pertumbuhan, hingga reproduksi, selain sebagai penerangan. Sistem perkandangan unggas modern menggunakan beragam sumber cahaya, salah satunya adalah light emitting diode (LED). Aspek pencahayaan yang diterapkan pada budi daya unggas dan masih terus diteliti hingga saat ini terdiri atas tiga hal penting, yaitu intensitas, warna, dan fotoperiode cahaya. Tujuan dari review artikel ini adalah mengkaji peran cahaya pada respons pertumbuhan dan performa reproduksi unggas. Penggunaan cahaya biru dan hijau meningkatkan pertumbuhan pada broiler dan puyuh, sedangkan pertumbuhan itik Pekin meningkat dengan adanya paparan cahaya biru dan merah. Cahaya merah maupun penggunaan cahaya dengan fotoperiode 16 L:8D meningkatkan sintesis dan sekresi estradiol pada unggas lokal sehingga dalam jangka panjang dapat meningkatkan jumlah folikel ovari yang fungsional dan menjamin produksi telur berkelanjutan. Kata kunci: cahaya monokromatik, unggas, pertumbuhan, estradiol
Kandungan Protein, Indeks Putih Telur (IPT) dan Haugh Unit (HU) Telur Itik Setelah Perendaman dengan Larutan Daun Jambu Biji (Psidium guajava) yang disimpan pada Suhu 270C
Authors: Azizah Nur , Djaelani Muhammad Anwar , Mardiati Siti Muflichatun
Published: July 2018

Telur merupakan salah satu sumber protein hewani yang bergizi tinggi sehingga banyak di gemari dikalangan masyarakat. Protein telur mempunyai mutu yang tinggi, karena memiliki susunan asam amino esensial yang lengkap sehingga dijadikan patokan untuk menentukan mutu protein dari bahan pangan yang lain. Penelitian ini bertujuan untuk menganalisis kandungan protein, Haugh Unit (HU) dan Indeks Putih Telur (IPT) telur itik setelah diberi perlakuan pencucian dan perendaman dengan larutan daun jambu biji (Psidium guajava) yang disimpan pada suhu kamar dalam jangka waktu 28 hari. Penelitian ini menggunakan 45 butir telur itik dengan 9 perlakuan dan 5 kali ulangan, P0: kontrol, P1: cuci dan rendam hari 14, P2: cuci dan rendam hari 28, P3: cuci tidak rendam hari 14, P4: cuci tidak rendam hari 28, P5: tidak cuci rendam hari 14, P6: cuci tidak rendam hari 28, P7: tidak cuci tidak rendam hari 14, P8: tidak cuci tidak rendam hari 28, dengan lama penyimpanan telur 14 hari dan 28 hari pada suhu kamar. Penelitian ini menggunakan rancangan acak lengkap (RAL). Variabel pengamatan yaitu kadar protein, Indeks Putih Telur, serta Haugh Unit. Data yang diperoleh dianalisis dengan uji ANOVA pada taraf signifikan 5% dan dilanjutkan dengan uji Duncan dengan α=0,05. Hasil simpulan data menunjukkan penelitian perendaman telur dengan larutan daun jambu biji (Psidium guajava) yang disimpan dalam suhu 270C selama 28 hari dengan kadar tanin 3.90% dan perendaman selama 30 menit tidak efektif untuk mempertahankan protein, Indeks Putih Telur (IPT), dan Haugh Unit telur itik. Kata kunci : telur itik, haugh unit, indeks putih telur, protein, larutan daun jambu biji (Psidium guajava)
Histopatologi Hepar Tikus Wistar (Rattus norvegicus) Jantan setelah Pemberian Teh Kombucha Konsentrasi 100% dengan Waktu Fermentasi yang Berbeda
Authors: Nugraha Agung Putra , Isdadiyanto Sri , Tana Silvana
Published: July 2018

Hepar berfungsi sebagai biotransformasi, penyimpanan nutrisi dan detoksifikasi racun yang datang melalui makanan dan minuman. Minuman fermentasi dapat mempengaruhi kondisi jaringan hepar dan bobot badan karena hasil dari metabolit sekunder adalah alkohol dan beberapa asam organik. Penelitian ini dilakukan untuk mengkaji dan menganalisis pengaruh perlakuan teh kombucha fermentasi 6 (P1), 9 (P2) dan 12 (P3) hari fermentasi konsentrasi 100% terhadap jaringan hepar, diameter hepatosit, bobot badan, konsumsi pakan dan minum. Penelitian ini menggunakan 16 ekor tikus Wistar jantan terdiri atas 4 perlakuan dan 4 kali ulangan. Perlakuan penelitian ini terdiri dari P0 : perlakuan kontrol; P1, P2 dan P3 berturut-turut adalah perlakuan teh kombucha fermentasi 6, 9 dan 12 hari konsentrasi 100%. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL). Variabel yang diukur pada penelitian ini adalah diameter hepatosit, bobot badan, konsumsi pakan dan minum pada hewan uji. Data yang diperoleh dianalisis menggunakan Analysis of Variance (ANOVA) pada taraf kepercayaan 95% dan apabila terdapat perbedaan nyata, dilanjutkan uji Duncan. Hasil analisis data menunjukkan bahwa teh kombucha fermentasi 6, 9 dan 12 hari konsentrasi 100% tidak memiliki perbedaan nyata terhadap seluruh variabel. Histologi hepar terlihat normal dan tidak menunjukkan ciri-ciri kerusakan sel. Hal ini dapat disimpulkan bahwa teh kombucha dapat dikonsumsi aman oleh mammalia karena tidak menimbulkan kerusakan hepar pada hewan model penelitian. Kata kunci : histopatolgi, hepar, teh kombucha, bobot badan, tikus wistar (Rattus norvegicus)
Tebal Dinding dan Diameter Lumen Arteria Koronaria Tikus Putih Setelah Pemberian Teh Kombucha Kadar 100% Waktu Fermentasi 6, 9 dan 12 Hari
Authors: Isdadiyanto Sri
Published: July 2018

Tujuan penelitian ini untuk mengetahui pengaruh pemberian teh kombucha kadar 100% sebagai drinking water dengan variasi waktu fermentasi. Penelitian ini menggunakan Tikus putih (Rattus norvegicus) jantan  sebanyak 16 ekor umur 2 bulan, dengan perlakuan Teh kombucha yang difermentasi selama 6, 9 dan 12 hari pada suhu 25oC per oral. Penelitian ini menggunakan Rancangan Acak Lengkap dengan 4 perlakuan (selama 28 hari) dan 4 ulangan, yaitu : P0 = kontrol, tanpa tambahan teh kombucha, P1 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 6 hari, P2 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 9 hari, P3 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 12 hari. Variabel yang diukur adalah kadar kolesterol, HDL dan LDL. Data yang diperoleh dianalisis menggunakan ANOVA yang dilanjutkan dengan Uji Duncan dengan taraf kepercayaan 95% dengan menggunakan perangkat lunak SPSS 10,0. Hasil penelitian menunjukkan bahwa pemberian teh kombucha tidak mempengaruhi tebal dinding dan diameter lumen arteria koronaria tikus putih (Rattus norvegicus). Kata kunci: Rattus norvegicus, teh kombucha kadar 100%, tebal dinding, diameter lumen, arteri koronaria
Studi Pola Sebaran Buangan panas PT. Pertamina Up V Balikpapan Di Perairan Kampung Baru, Teluk Balikpapan
Authors: Rizkiyah Rizkiyah , Sugianto Denny Nugroho , Purwanto Purwanto
Published: July 2018

Teluk Balikpapan merupakan wilayah industri di Kalimantan, salah satunya terdapat industri pengolahan minyak dan gas bumi PT Pertamina UP V. Aktivitas pengolahan minyak dan gas bumi menghasilkan buangan sisa industri, salah satunya adalah buangan panas. Penelitian ini bertujuan untuk mengetahui pola sebaran buangan panas yang bersumber dari buangan PT. Pertamina UP V Balikpapan yang dipengaruhi oleh pola pergerakan arus. Data yang digunakan dalam penelitian ini berupa data arus,  pasang surut, peta batimetri, teperatur perairan, data temperatur dan debit buangan panas. Lokasi penelitian dilakukan di sekitar Perairan Kampung Baru, Teluk Balikpapan . Studi pola sebaran buangan panas dikaji dengan menggunakan pendekatan model hidrodinamika. Hasil simulasi model menunjukan bahwa kecepatan arus di Perairan Teluk Balipapan sebesar 0,01 m/det – 0,53 m/det dengan arah arus dominan selatan dan utara. Jarak terjauh sebaran panas terjadi saat kondisi purnama periode pasang tertinggi yaitu bergerak sejauh 1,44 km ke arah selatan dari titik outlet dengan temperatur buangan sebesar 36˚C hingga temperatur normal perairan sebesar 29˚C. Kata Kunci : Sebaran buangan panas, arus, temperatur perairan, Teluk Balikpapan.
Potensi Pemanfaatan Teripang (Holothurians) di Perairan Karimunjawa, Kabupaten Jepara, Provinsi Jawa
Authors: Sulardiono Bambang
Published: July 2018

Terdapat beragam spesies teripang (Holothurians) yang hidup di Perairan Karimunjawa, yang menempati berbagai substrat dasar pada ekosistem terumbu karang. Teripang bernilai ekonomis. Penangkapan dilakukan secara terus menerus tanpa adanya pengawasan. Hal  inilah yang menyebabkan jumlah populasi teripang H. scabra menurun dengan tajam. Oleh sebab itu perlu diadakan penelitian untuk mengetahui kondisi potensi teripang (holothurians) tersebut. Tujuan penelitian adalah mengetahui (a) komposisi spesies teripang di perairan Karimunjawa  (b) potensi populasi teripang di perairan Karimunjawa, dan (c) potensi pemanfatan teripang di perairan Karimunjawa. Metode pengumpulan data menggunakan transek garis 100 m yang dimodifikasi untuk reef check. Pengukuran dilakukan selama 1 tahun dengan interval waktu 1 bulan. Lokasi penelitian di perairan Karimunjawa,   dibagi dalam 5 titik sampling yaitu stasiun A Menjangan Kecil, Stasiun B Legon Goprak, Stasiun C Karang Gumuk, Stasiun D Alang-alang, dan Stasiun E Mrican. Hasil penelitian menunjukkan bahwa terdapat 15 spesies  teripang yang termasuk dalam ordo Aspidochirotidae dan 2 famili yaitu 11 spesies dari famili  Holothuridae dan 4 spesies dari famili Stichopodidae. Potensi biomassa populasi seluruh spesies yang dimanfaatkan dalam area studi sampai pada kedalaman 10 m, diketahui sebesar 44.641.789  individu dengan nilai potensi leatari (MSY) sebesar 24.590.814  individu per tahun, dengan kuota pengambilan yang diperbolehkan  sebesar 20.277.981  individu per tahun. Potensi biomassa populasi spesies yang paling rendah adalah H. scabra, Actinopyga sp, dan A. lecanora masing-masing sebesar 756.594 individu, 756.458 individu, dan 1.134.823 individu,  dengan nilai potensi lestari (MSY) masing – masing untuk H. scabra sebesar 378.297 individu per tahun, Actinopyga sp sebesar 567.411 individu per tahun dan A. lecanora sebesar 378.229 individu per tahun, serta dengan kuota pengambilan masing-masing sebesar  302.637individu per  tahun, 302.583 individu per tahun, dan  302.583  individu per tahun. Untuk dapat meningkatkan populasi Sumberdaya teripang (Holothurian) di perairan Karimunjawa secara lestari, maka strategi yang dilakukan adalah dengan mengembangkan sifat altruistik positip (responsible optimistic).   Kata kunci : teripang, potensi lestari, dan kuota tangkapan
Keberadaan Krustasea di Kawasan Vegetasi Mangrove Tugurejo, Semarang
Authors: Hartati Retno
Published: July 2018

Hutan mangrove merupakan ekosistem yang unik karena terjadi akibat perpaduan antara habitat darat dan laut. Ekosistem mangrove juga merupakan tempat hidup berbagai jenis hewan benthos termasuk krustasea yang memegang peranan penting dalam ekosistem tersebut. Adanya perubahan fungsi lahan untuk berbagai kepentingan manusia diduga akan berpengaruh terhadap kondisi kelimpahan krustaseayang terdapat di kawasan tersebut. Penelitian ini bertujuan untuk menganalisais komposisi dan struktur komunitas makrozoobenthos krustasea di kawasan mangrove Tugurejo, Semarang. Pengambilan sampel dilakukan dengan 2 metode yaitu kualitatif dan kuantitatif. Hasil penelitian menunjukkan terdapat 22 jenis makrozoobenthos krustasea, dari Infra Ordo Brachyura ditemukan 14 jenis yang termasuk ke dalam 5 famili, Infra Ordo Macrura ditemukan 4 jenis yang termasuk ke dalam 4 famili, dari Isopoda ditemukan 3 jenis dan dari Copepoda ditemukan satu jenis biota. Nilai indeks keanekaragaman semua stasiun termasuk kategori sedang. Indeks keseragaman rendah sampai  tinggi. Terdapat dominansi species di Stasiun B (vegetasi pohon) dan C (vegetasi sapling).  Pola sebaran krustasea mengelompok. Nilai indeks kesamaan komunitas termasuk kategori rendah dan tinggi. Secara umum jumlah krustasea pada infra ordo Brachyura jantan lebih banyak dari betina, dan jumlah infra ordo Brachyura betina yang bertelur 23,07% dari jumlah betina yang ditemukan. Kata Kunci : Mangrove, Krustasea, Komposisi dan Kelimpahan
Ekspresi Gen dan Laju Sintasan Udang Vaname (Litopenaeus vannamei) yang Tersuplementasi Dengan Alginat Secara Oral Untuk Resistensi Penyakit White Spot Syndrome Virus
Authors: Yudiati Ervia
Published: July 2018

Tingkat eskpresi gen Lectin/Toll dan laju sintasan ditentukan setelah udang vaname diberi pakan yang mengandung alginat dengan dosis berbeda dan diuji tantang dengan WSSV. Ekspresi gen dilakukan dengan qRT-PCR dan dihitung dengan metode komparatif menggunakan β–actin sebagai kontrol internal. Laju sintasan dihitung pada jam ke 96 setelah uji tantang. Ekspresi gen Lectin pada Udang mengalami up-regulated setelah uji tantang, sedangkan ekspresi gen Toll mengalami down-regulated. Laju sintasan pada udang yang diberi suplementasi alginat 2,0 g.kg-1 dan 4,0 g.kg -1 lebih tinggi (P<0,05) apabila dibandingkan dengan tanpa suplementasi.   Kata kunci: ekspresi gen, laju sintasan, Litopenaeus vannamei, alginat
Bakteri Simbion Karang Porites dari Perairan Gunungkidul, Yogyakarta dan Aktivitas Antibakteri terhadap Bakteri Patogen Staphylococcus aureus dan Escherichia coli
Authors: Madilana Rivan Novianto , Wijayanti Diah Permata , Sabdono Agus
Published: July 2018

Porites merupakan genus karang yang memiliki persebaran luas di Indonesia, termasuk perairan Gunungkidul, Yogyakarta. Penelitian menunjukkan bahwa bakteri simbion karang Porites memiliki potensi antibakteri dalam menanggulangi bakteri patogen. Penelitian ini betujuan untuk mengetahui jenis bakteri simbion karang Porites dari Perairan Gunungkidul Yogyakarta yang memiliki aktivitas antibakteri patogen S. aureus dan E. coli. Bakteri simbion diisolasi dari fragmen jaringan karang dengan pengenceran bertingkat, kemudian uji aktivitas antibakteri dilakukan dengan menggunakan metode overlay dan difusi paperdisk. Delapan dari 64 isolat aktif menghambat kedua bakteri patogen Staphylococcus aureus dan Escherichia coli. Dua diantaranya merupakan isolat unggul yang menunjukkan aktivitas antibakteri paling baik. Kedua isolat selanjutnya diidentifikasi karakteristik molekular DNA dengan sekuen gen 16S rRNA. Hasil identifikasi 16S rRNA menunjukkan isolat GKP1.4.3 memiliki kesamaan 99% dengan Bacillus pumilus strain NBRC 12092, dan isolat GKP3.2.2 memiliki kesamaan 99% dengan Vibrio natriegens strain NBRC 15636.Porites is a coral which has distributed widely in Indonesia, including Gunungkidul Waters, Yogyakarta. Research has shown that Porites coral symbiont bacteria have antibacterial potency against pathogenic bacteria.This study aims to determine the type of Porites coral symbiont bacteria collected from the waters of Gunungkidul Yogyakarta which has antibacterial activity of S. aureus and E. coli. Bacteria symbionts were isolated from coral tissue fragments by serial dillution method, while antibacterial activity was performed by using overlay and paperdisk diffusion method. Eight of the 64 active isolates inhibited both pathogenic bacteria S. aureus and E. coli. Two of 8 isolates showed stronger antibacterial activity. The two isolates subsequently identified the molecular characteristics of DNA with the 16S rRNA gene sequence. The identification of 16S rRNA showed that GKP1.4.3 isolate had 99% similarity with Bacillus pumilus strain NBRC 12092, and GKP3.2.2 isolate had 99% similarity with Vibrio natriegens strain NBRC 15636.
PUNAN LONGSEP: WACANA YANG BETERBANGAN PADA ORANG PUNAN DI TENGAH AREAL HAK GUNA USAHA DI KALIMANTAN TIMUR
Authors: Hermawan Damasus Ferix Loys
Published: July 2018

(Negotiation of Punan in The Area of Cultivation Rights (HGU) in East Kalimantan) Punan merupakan salah satu penghuni asli hutan Kalimantan yang menggantungkan hidupnya dari hasil hutan. Peralihan fungsi hutan mengganggu aktivitas mereka mengelola dan memperoleh hasil hutan. Negosiasi berupa interaksi dan komunikasi yang terjadi antara Orang Punan dan perusahaan di Longsep memberikan dampak perubahan pada hidup Orang Punan. Beragam wacana  yang muncul dan berkembang dari negosiasi interaksi itu kemudian diidentifikasi saat observasi dilakukan. Dari hasil identifikasi data tersebut diperoleh terdapat beberapa wacana yang beterbangan yang menunjukkan bahwa terdapat wacana berperan mendominasi kehidupan Orang Punan di Longsep.Wacana dominan inilah yang menguatkan hipotesa bahwa telah terjadi dominasi yang terakulasi pada perubahan pola  kehidupan Orang Punan di Longsep. Perubahan kehidupan dialami Orang Punan atas dominasi wacana perusahaan telah  membuatnya bergantung dan tidak dapat berbuat banyak (“tanpa perusahaan”) ketika menjalani hidup dan kesehariannya di Longsep. Wacana perusahaan telah membangun serta membentuk cara pandang dan orientasi hidup Orang Punan di Longsep. Hal inilah yang dipandang sebagai dasar berbagai perubahan hidup Orang Punan Longsep.
Towards accurate rescaling of a halo mass function
Authors: Yankelevich Victoria , Pilipenko Sergey V.
Published: July 2018

We investigate the precision within which a simulated dark matter halo mass function can be rescaled to a different set of cosmological parameters. Our tests show that the accuracy almost linearly depends on the difference of the cosmological parameters and amounts to few percent in the case of WMAP5 and PLANCK parameters. The rescaling thus allows us to obtain a mass function with better precision than the one given by the Sheth-Mo-Tormen approximation and even more modern fits currently used in the literature.
Signaling in monetary policy near the zero lower bound
Authors: Salas Sergio , Nuñez Javier
Published: July 2018

What are the consequences of asymmetry of information about the future state of the economy between a benevolent Central Bank (CB) and private agents near the zero lower bound? How is the conduct of monetary policy modified under such a scenario? We propose a game theoretical signaling model, where the CB has better information than private agents about a future shock hitting the economy. The policy rate itself is the signal that conveys information to private agents in addition to its traditional role in the monetary transmission mechanism. We find that only multiple “pooling equilibria” arise in this environment, where a CB privately forecasting a contraction will most likely follow a less expansionary policy compared to a complete information context, in order to avoid making matters worse by revealing bad times ahead. On the other hand, a CB privately forecasting no contraction is most likely to distort its complete information policy rate, the consequences of which are welfare detrimental. However, this is necessary because deviating from the pooling policy rate would be perceived by private agents as an attempt to mislead them into believing that a contraction is not expected, which would be even more harmful for society.
Inflation targeting and exchange rate regimes in emerging markets
Authors: Ebeke Christian , Fouejieu Armand
Published: July 2018

This paper investigates the effects of the adoption of inflation targeting (IT) on the choice of exchange rate regime in emerging markets (EMs), conditional on certain macroeconomic conditions. Using a large sample of EMs and after dampening the endogeneity of the adoption of IT using a selection on observables, we find that IT countries on average have a relatively more flexible exchange rate regime than other EMs. However, the flexibility of the exchange rate regime shows strong heterogeneity among IT countries. IT countries with low trade and financial openness and with a large share of external debt exhibit a lower exchange rate flexibility than others. Moreover, the marginal effect of IT adoption on the exchange rate flexibility increases with the duration of the IT regime in place, and with the propensity scores to adopt it.
Characterization of Haemophilus parasuis Serovar 2 CL120103, a Moderately Virulent Strain in China
Authors: Che Yongliang , Wang Longbai , Wu Xuemin , Chen Rujing , Wang Chenyan , Zhou Lunjiang
Published: July 2018

Haemophilus parasuisis an important bacterium affecting pigs, causing Glässer’s disease. To further characterize this species, we determined the complete genomic sequence ofH. parasuisCL120103, which was isolated from diseased pigs. The strainH. parasuisCL120103 was identified as serovar 2. The size of the largest scaffold is 2,326,318 bp and contains 145 large contigs, with the N50 contig being 20,573 bp in length. The complete genome ofH. parasuisCL120103 is 2,305,354 bp in length with 39.97% GC content and contains 2227 protein-coding genes, 19 ribosomal rRNA operons and 60 tRNA genes. Sequence similarity of the genome ofH. parasuisCL120103 to the previously sequenced genome ofH. parasuiswas up to 96% and query cover to 86%. Annotation of the genome ofH. parasuisCL120103 identified a number of genes encoding potential virulence factors. These virulence factors are involved in metabolism, adhesion, secretion and LPS biosynthesis. These related genes pave the way to better understand mechanisms underlying metabolic capabilities. The comprehensive genetic and phylogenetic analysis shows thatH. parasuisis closely related toActinobacillus pleuropneumoniaeand provides a foundation for future experimental confirmation of the virulence and pathogen-host interactions inH. parasuis.
Telmisartan induces osteosarcoma cells growth inhibition and apoptosis via suppressing mTOR pathway
Authors: Wang Chao , Wang Wen-Bo
Published: July 2018

Osteosarcoma (OS) is a commonly occurring primary malignant bone cancer with serious impact and high mortality, yet effective and safe therapy method not available. The aim of the present study was to elucidate the antitumor effect of telmisartan on human osteosarcoma cells in vitro and its underlying mechanism. The proliferation effect of osteosarcoma cell lines U2OS was examined by Cell Counting Kit-8. The invasive and migratory capabilities were determined by transwell invasion and migration assay. The percentage of apoptotic cells were detected by flow cytometric analysis and proteins related to apoptosis including Bax, Bcl-2 and Cleaved Caspase-3 were examined by western blotting. The expressions of mammalian target of rapamycin (mTOR) signaling relevant molecules were detected by western blot assay. Telmisartan treatment caused dose-dependent and time-dependent inhibition of proliferation and inducing anti-migration, anti-invasiveness and apoptosis of U2OS cells. The induction of apoptosis was confirmed concurring with the altered expression of proteins associated with the apoptosis. Mechanistically, telmisartan suppresses mTOR activation. Telmisartan can impede the growth, invasion, migration and induce the apoptosis of U2OS cell probably through inhibiting the mTOR signaling pathway activation. Thus, telmisartan is a potential drug for the prevention and treatment of human osteosarcomal cancer.