bluuebunny/crossref_metadata_2025 huggingface dataset:
Increased Serum Levels of Phoenixin-14, Nesfatin-1 and Dopamine Are Associated with Positive Pregnancy Rate after Ovarian Stimulation
Authors: Piróg Magdalena , Jach Robert , Ząbczyk Michał , Natorska Joanna
Published: November 2023

Background: We study the relationship between phoenixin (PNX-14), nesfatin-1 (NES-1), dopamine (DA) and oxytocin (OT) levels together with pregnancy rates in women after ovarian stimulation (OS). Methods: In a prospective case–control study, 56 infertile women were enrolled from the Department of Gynecological Endocrinology University Hospital. Infertile women age < 40 years old, with polycystic ovary syndrome (PCOS), confirmed tubal patency and suitable sperm quality were included. Blood samples were drawn twice—before the initiation of OS and before the human chorionic gonadotropin (hCG) administration. Assessments of PNX-14, NES-1, DA and OT serum levels were performed. Pregnancy rates after OS were observed. Results: Pregnant women showed higher baseline NES-1 and OT levels (+29.2% and +44%) but not PNX-14 and DA levels when compared to non-pregnant ones. In pregnant women, positive correlations between OT and prolactin, PRL (r = 0.47, p = 0.04), as well as between OT and NES-1 (r = 0.55, p = 0.02), were observed at baseline. At baseline, an OT level increase was associated with a positive pregnancy rate (per 100 pg/mL, OR = 1.39, 95% CI 1.04–1.74), while after OS, higher PNX-14 was a predictor of pregnancy (by 10 pg/mL, OR = 1.23, 95%CI 1.07–1.39). Post-stimulation PNX-14, NES-1 and DA concentrations were higher in pregnant women compared to non-pregnant ones (+17.4%, +26.1%, and +45.5%, respectively; all p < 0.05). In the pregnant group, OT levels were 2.7-times lower than in the remainder (p = 0.03). Moreover, in pregnant participants, a negative association between NES-1 and PNX (r = −0.53, p = 0.024) was observed. Conclusion: Elevated PNX-14, NES-1 and DA along with decreased OT levels were observed in women who achieved pregnancy.
Is the Direct Fixation of Displaced Quadrilateral Plates in Acetabular Fractures Necessary?
Authors: Kim Beom-Soo , Bae Ki-Cheor , Cho Chul-Hyun , Lee Kyung-Jae , Lee In Gyu , Lee Min-Gyu , Min Byung-Woo
Published: November 2023

Quadrilateral plate fractures represent a heterogeneous group of acetabular fractures. Accurate reduction is required to prevent post-traumatic arthritis. The purpose of this study is to determine the reduction effect of the direct fixation of quadrilateral plates in acetabular fractures, and to evaluate the strength of direct fixation compared to indirect fixation. Between 2005 and 2021, 49 patients underwent surgery for open reduction and internal fixation in acetabular fractures with severely displaced quadrilateral plates. Twenty-nine patients comprised the indirect fixation group, and twenty patients comprised the direct fixation group. In a comparison of primary outcome between two groups, 10 out of 29 indirect-group patients and 1 out of 20 direct-group patients developed post-traumatic osteoarthritis, wherein the difference between the two groups is statistically significant. In the assessment of postoperative Matta’s radiological reduction status, 19 out of 20 patients in the direct group had achieved anatomical and congruent reduction. The treatment using a direct reduction and internal fixation improved the reduction quality of articular displacement and offered a better survivorship of the affected hip joint.
Outcomes of Urinary Tract Endometriosis—Laparoscopic Treatment: A 10-Year Retrospective Study
Authors: Rocha Maria Alexandra , Mendes Gonçalo , Castro Luis Ferreira , Mesquita Sofia , Teixeira Bernardo Lobão , Madanelo Mariana , Vital João Aragão , Marques-Monteiro Miguel , Vinagre Nuno , Oliveira Beatriz , Magalhães Martinha , Príncipe Paulo , Ferreira Hélder , Silva-Ramos Miguel
Published: November 2023

Introduction: Urinary tract endometriosis (UTE), a rare manifestation, encompasses bladder and ureteral involvement. Surgical intervention is commonly recommended for UTE, though the optimal surgical approach remains a subject of debate. This study aims to report our centre’s experience with UTE. Methods: We conducted a retrospective cohort study of 55 patients who underwent surgical treatment for UTE at a single tertiary centre over a 10-year period (2012–2022). Patient data, including demographics, symptoms, intraoperative findings, and complications, were collected from medical records. Data were statistically analysed, and correlations were explored. Results: The study population had a mean age of 37.11 years, with dysmenorrhea (89.1%) being the most common symptom. Bladder endometriosis was present in 27 cases, ureteral endometriosis in 25, and mixed-location in 3. Laparoscopy was the primary surgical approach, with multidisciplinary teams involving urologists. There were six patients with postoperative complications, and there were six (10.9%) recurrences of endometriosis. A positive correlation was found between age and recurrence, but no significant predictors of recurrence were identified in our analysis. Conclusions: Laparoscopic treatment of urinary endometriosis is safe and effective. Multidisciplinary collaboration plays a pivotal role in addressing this challenging condition.
Navigating Challenges in the Endovascular Treatment of Asymptomatic Aortoiliac Aneurysms: A 10-Year Comparative Analysis
Authors: Chinsakchai Khamin , Ketklin Natcha , Hongku Kiattisak , Wongwanit Chumpol , Puangpunngam Nattawut , Hahtapornsawan Suteekhanit , Thongsai Sasima , Prapassaro Tossapol , Sermsathanasawadi Nuttawut , Ruangsetakit Chanean , Mutirangura Pramook
Published: November 2023

Background: Treating an abdominal aortoiliac aneurysm (AAIA) with endovascular methods can be challenging when the internal iliac artery (IIA) is involved. Embolizing the IIA and extending the limb to the external iliac artery (IIAE + EE) to prevent a type 2 endoleak may lead to pelvic ischemic complications. To avoid these complications, strategies that preserve the IIA, such as the bell-bottom technique (BBT) and the iliac branch device (IBD), have been proposed. This study aims to compare the outcomes of these three endovascular approaches for AAIA. Methods: Between January 2010 and December 2019, 174 patients with asymptomatic AAIA were enrolled in this retrospective analysis. They were divided into two groups: 81 patients underwent non-IIAE procedures, and 93 patients underwent IIAE procedures. The iliac limb study group consisted of 106 limbs treated with the BBT, 113 limbs treated with the IIAE + EE, and 32 limbs treated with the IBD. The primary outcomes included the 30-day mortality rate and intraoperative limb complications. The secondary outcomes included postoperative pelvic ischemia, freedom from reintervention, and the overall 10-year survival rate. Results: There was no significant difference in the perioperative mortality rate between the non-IIAE group (0%) and the IIAE group (2.1%), p = 0.500. The intraoperative limb complications did not differ significantly between the BBT limbs (7.5%), the IIAE + EE limbs (3.5%), and the IBD limbs (3.1%) groups, p = 0.349. The incidence of buttock claudication was significantly greater in the bilateral IIAE + EE group compared to the unilateral IIAE + EE and non-IIAE groups (25%, 11%, and 2.5%, p-value < 0.004), and was similar to the incidence of buttock rest pain with skin necrosis (15%, 0%, and 0%, p < 0.001). During the 10-year follow-up, the BBT limbs group had a significantly lower rate of iliac limb reintervention free time than the IIAE + EE limbs and the IBD limbs groups (88.7%, 98.2%, and 93.8%, p = 0.016). There was no significant difference in the overall 10-year survival rate between the non-IIAE and IIAE groups (51.4% vs. 55.9%, p = 0.703). Conclusions: The early and late mortality rates were similar between the non-IIAE and IIAE groups. Preserving the IIA is recommended to avoid pelvic ischemic complications. Considering the higher rate of reintervention in the BBT group, the IBD strategy may be preferred for AAIA.
Correction: Bauer et al. Challenges for Optimization of Reverse Shoulder Arthroplasty Part II: Subacromial Space, Scapular Posture, Moment Arms and Muscle Tensioning. J. Clin. Med. 2023, 12, 1616
Authors: Bauer Stefan , Blakeney William G. , Wang Allan W. , Ernstbrunner Lukas , Corbaz Jocelyn , Werthel Jean-David
Published: November 2023

In the original publication [...]
Fellow-Eye Comparison between Phaco-Tanito Microhook Trabeculotomy and Phaco-iStent Inject W
Authors: Harano Akiko , Shimada Ayaka , Ichioka Sho , Sugihara Kazunobu , Tanito Masaki
Published: November 2023

This study aims to compare the surgical efficacy and safety of the Tanito microhook trabeculotomy (TMH-CE) and iStent inject W (Inject-CE) when performed in combination with cataract surgery on the eyes of glaucoma patients. A total of 78 glaucomatous eyes from 39 participants were retrospectively analyzed. Intraocular pressure (IOP), the number of antiglaucoma medications, best-corrected visual acuity (BCVA), anterior chamber flare (ACF), and corneal endothelial cell density (CECD) were all evaluated preoperatively and at multiple postoperative time points. The preoperative IOP was significantly higher in the TMH-CE (19.6 ± 6.7 mmHg) than in the Inject-CE (15.7 ± 3.8 mmHg) (p < 0.0001). At the 12-month follow-up, reductions in IOP and the number of medications were more pronounced in the TMH-CE (6.6 mmHg, 27.6% and −1.1, respectively) group than Inject-CE (2.7 mmHg, 12.4% and −0.7, respectively) (p < 0.0001 and p = 0.0034), while the IOP and medication-number levels were identical between TMH-CE (13.0 ± 3.3 mmHg and 1.3 ± 0.9, respectively) and Inject-CE (12.9 ± 2.6 mmHg and 1.9 ± 0.9, respectively) (p = 0.88 and p > 0.99, respectively). The TMH-CE group exhibited a higher ACF, a higher frequency of layered hyphema, and a greater anterior chamber floating red blood cells score in the early postoperative periods. Despite these differences, the changes in BCVA, ACF, and CECD were equivalent between the two groups in later follow-up periods. TMH-CE provides a more significant IOP reduction and medication-number reduction compared to Inject-CE, while Inject-CE shows quicker BCVA recovery. This study provides valuable insights for ophthalmologists choosing the most suitable surgical approach for glaucoma and cataract patients.
The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil
Authors: Hirata Lilian T. , Teixeira Carlos Eduardo G. , Magalhaes Eduardo P. , Del Rio Ana Paula T. , Coimbra Ibsen Bellini , Sachetto Zoraida
Published: November 2023

Objective: Modifications in the severity and clinical expression of Behçet’s disease (BD) have been described in some areas that are considered endemic for the disease. This study aims to evaluate the chronological changes in epidemiology and clinical characteristics of BD patients in a referral center in Brazil, which is considered a non-endemic area for the disease. Methods: A descriptive and cross-sectional study involving BD patients divided into two groups: group 1 patients were diagnosed and followed between 1988 and 2010, and group 2 were diagnosed and followed between 2011 and 2022. Results: No significant differences were found regarding gender and age at onset of symptoms between groups. We found a significant decrease in the frequency of bilateral ocular involvement, posterior uveitis, and retinal vasculitis. Conclusion: The demographic dates of this group of Brazilian BD patients remained similar over the last decade. Our study supports the notion that BD is becoming lighter in some regions. BD is a severe blinding disorder, and we found a lower frequency of ocular involvement over time. These findings may be attributed to a higher level of education of patients and a growing awareness of the disease. Newer immunomodulating and biologic agents may offer an improved prognosis in patients with BD with severe manifestations.
Gender Differences in Antitussive Prescriptions for Chronic Cough in Korea
Authors: Park Jinkyeong , Hong Yoonki , Hong Ji Young
Published: November 2023

Background: We investigated the differences in the characteristics and prognoses between the sexes of patients with chronic cough who were prescribed antitussive agents, using a Korean population-based database. Methods: Claims data from South Korea’s Health Insurance Review and Assessment (HIRA) service were analyzed. This retrospective observational cohort study considered chronic cough patients aged 18 years and older who were consistently prescribed antitussive agents for more than 2 months between 1 January 2017 and 30 June 2019. Results: Among the 207,989 patients treated for chronic cough, the prevalence of unexplained cough was higher in women (men: 6.2% vs. women: 9.7%) and the prevalence of persistent cough was higher in men (men: 16.8% vs. women: 14.3%). The gap in the proportion of COPD, lung cancer, ILD, GERD, and TB between women and men were largest around the age range of 60–70 years. With the exception of those in their 60s and 70s, women were more likely to have chronic cough and persistent cough than men. Women were more likely to discontinue medication after treatment completion than men. Only 53.9% of patients discontinued cough medication for more than 6 months after treatment completion. Within 12 and 18 months, respectively, 8.9% and 11.9% of them revisited the hospital for chronic cough. Via Cox regression analysis, an age in the 60s or 70s and explained cough were independently associated with a higher risk of revisit for treatment. Conclusions: Among patients treated for chronic cough, there were distinct differences in cough characteristics and prescription status between men and women. Our data highlight the need for a new personalized treatment approach to chronic cough, taking into account the gender, age, and underlying diseases of patients. Further research is needed to determine whether appropriate underlying disease control and gender-specific treatment are effective for managing chronic cough.
Hyperthermic Intraperitoneal Chemotherapy (HIPEC): New Approaches and Controversies on the Treatment of Advanced Epithelial Ovarian Cancer—Systematic Review and Meta-Analysis
Authors: Della Corte Luigi , Conte Carmine , Palumbo Mario , Guerra Serena , Colacurci Dario , Riemma Gaetano , De Franciscis Pasquale , Giampaolino Pierluigi , Fagotti Anna , Bifulco Giuseppe , Scambia Giovanni
Published: November 2023

Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery has been extensively studied in patients with peritoneal carcinomatosis, and it holds promise as a therapeutic strategy, but its role remains elusive. The aim of this study was to assess the existing evidence for the use or not of HIPEC in primary debulking surgery (PDS), interval debulking surgery (IDS), and recurrent ovarian cancer (ROC), evaluated in terms of survival rates and post-surgical morbidity. Methods: Medline, Pubmed, Cochrane, and Medscape were systematically searched for any article comparing the use of HIPEC treatment with any other therapy in patients with ovarian cancer in PDS, IDS, and ROC. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines were followed. We only considered English-language published studies. Results: We included 14 studies, including two RCTs with a total of 1813 women, published between 2003 and 2023 with a recruitment period between 1998 and 2020. In PDS, there were no differences in progression-free survival (PFS) between HIPEC and controls [MD −5.53 months [95% CI −19.91 to 8.84 months]; I2 = 96%]. Conversely, in patients treated with NACT, pooled results showed a significant survival advantage in terms of progression-free survival (PFS) and overall survival (OS) in the combined HIPEC plus IDS group rather than surgery alone [PFS: MD 4.68 months (95% CI 3.49 to 5.86 months, I2 = 95%); OS: MD 11.81 months (95% CI 9.34 to 14.27 months); I2 = 97%]. Concerning ROC patients, pooled MD did not show either a significant PFS difference between intervention and controls [MD 2.68 months (95% CI 433 to 9.70 months); I2 = 95%], and OS significant difference (MD 6.69 months [95% CI −9.09 to 22.47 months]; I2 = 98%). Severe post-operative complications (≥grade 3) were available in 10 studies, accounting for 1108 women. Overall, there was a slightly but significantly increased risk with the combined approach compared to controls [RR 1.26 (95% CI 1.02 to 1.55); I2 = 0%]. Conclusions: The combination of HIPEC with cytoreductive surgery prolongs OS and PFS in advanced epithelial ovarian cancer after NACT with acceptable morbidity. However, additional trials are still needed to determine the effectiveness of HIPEC in primary and recurrence settings. In the era of personalized medicine, the correlation between the efficacy of HIPEC and biological and molecular findings represents a challenge for the future of ovarian cancer.
Influence of Landscape Preference and Place Attachment on Responsible Environmental Behavior—A Study of Taipei’s Guandu Nature Park Wetlands, Taiwan
Authors: Wu Szu-Ju , Ng Eric , Lin Kai-Bo , Cheng Yi-Hsin , LePage Ben A. , Fang Wei-Ta
Published: November 2023

Wetlands provide important ecological services and aesthetic value at the landscape level. A landscape that makes people feel or appreciate the beauty of nature and is ecologically healthy and aesthetically beautiful can elicit positive emotions for people that are exposed to such landscapes. This then translates into protective environmental behaviors. Despite the growing importance of wetland conservation and human sensitivities to landscapes, little is known about the relationship between wetland landscapes and responsible environmental behaviors (REBs). This study was conducted at the wetlands at Guandu Nature Park (GNP), Taipei, Taiwan, using a five-point Likert scale questionnaire. Partial least squares structural equation modeling was used to test three hypotheses aiming to examine the influence of (1) landscape preference on REBs, (2) landscape preference on place attachment, and (3) place attachment on REBs. The findings indicated individuals displayed environmentally friendly behaviors because of the healthy environmental conditions of GNP wetlands and that an individuals’ sense of place attachment was influenced by the beauty of these wetlands. In addition, place attachment had a mediating effect on landscape preference and REBs. This study contributes to the limited resources associated regarding the effects of wetland landscapes on REBs and provides a basis for future comparative studies.
Assessing the Vulnerability of Nomadic Pastoralists’ Livelihoods to Climate Change in the Zhetysu Region of Kazakhstan
Authors: Baytelieva Anar , Lee Woo-Kyun , Wang Sonam Wangyel , Iskakova Aliya , Ziyayeva Gulnar , Shilibek Kenzhegali , Azatov Nurakhmet , Zholamanov Nurzhan , Minarbekov Zhamalkhan
Published: November 2023

Kazakhstan is historically a livestock-producing country. For the first time in this study, we attempted to assess the vulnerability of nomadic pastoralists in Kazakhstan to climate change using the Livelihood Vulnerability Index (LVI). To collect data, a survey of 100 household heads was conducted on fourteen main components and fifty-six sub-components. The study was conducted in the period from May to July 2022 in the Panfilov (PD) and Kerbulak (KD) districts of the Zhetysu region, where the Altyn-Emel State National Nature Park is located. The results of the study were combined using a composite index method and comparing different vulnerability indicators. Natural disasters, which manifest as the effects of drought, temperature fluctuations, and precipitation, contribute most to the vulnerability of nomads living in remote mountain areas with a complex infrastructure. According to the results of the study, nomads of both regions have high vulnerability in such components as natural resources, human–wildlife conflict, housing type, agriculture and food security, and social networks. High vulnerability in the “Finances and incomes” component was found only in the pastoralists of the PD. Identifying the levels of vulnerability of nomadic households to climate change, as well as understanding their adaptation strategies, will enable pastoralists to gain access to new ways of reducing the vulnerability of their livelihoods. Currently, the country practices a strategy to reduce the vulnerability of pastoral nomads’ livelihoods by insuring livestock against natural or natural hazards and other risks; involving the population in environmental-protection activities and helping them to obtain sustainable financial resources when they refuse to hunt endangered animals; non-agricultural diversification of high-altitude ecotourism in rural areas in their area of residence; and improving financial literacy by providing training and providing information on low-interest loans under state projects and livestock subsidy mechanisms, as well as training in organizing cooperatives within the framework of legal status, which will ensure them stable sales of products and income growth. The results of software research serve as a basis for taking measures within the framework of the development and implementation of state programs for climate change adaptation of the Environmental Code of the Republic of Kazakhstan, where agriculture is one of the priority areas of management.
Paludiculture in Latvia—Existing Knowledge and Challenges
Authors: Ozola Ilze , Dauskane Iluta , Aunina Ieva , Stivrins Normunds
Published: November 2023

Global climate change impact has increased in recent decades and put urgency on implementing effective climate change mitigation (CCM) activities. Rewetting of drained peatlands is an acknowledged measure to reduce GHG emissions from organic soils in the agriculture and land use sectors. Under waterlogged conditions, decomposition of organic matter in peat decreases, and emissions of CO2 are reduced. Thus, the soil carbon stock is saved, and wet management of the site reactivates carbon sequestration. To reach CCM targets, the first rewetting and paludiculture trials have been implemented in Latvia. In this article, we review the current status of paludiculture in Latvia and evaluate the pros and cons of their wider implementation. The majority of paludiculture projects and pilot studies in Latvia have not been published so far and are reported here for the first time. Our assessment of paludiculture shows that trails on Alnus, Phalaris, Phragmites, Sphagnum, and Typha installed by the private enterprises have promising results for upcoming large-scale implementation. There are available areas for paludiculture in Latvia, but the current legislation and national framework policies (environment, agriculture, forest, and climate) do not fully support such activities yet and must be adapted.
Effect of Ceramic Particles on Ni-Based Alloy Coating Fabricated via Laser Technology
Authors: Zhang Yanhua , Wang Yinan , Wang Li , Jin Ying , Wang Zhaofeng , Shi Xiaoling
Published: November 2023

Laser cladding is a new technology for fabricating coatings with good properties, such as wear resistance, lubrication, and corrosion resistance. Usually, parts of 45 steel are used as a shaft under conditions of high-speed rotation or friction and wear, and they have a short service life and sometimes cause accidents. In order to avoid serious accidents, a cladding coating made from a Ni-based alloy with ceramic particles was fabricated via laser technology on a substrate of 45 steel in this research. The microstructure and properties were investigated via SEM, EDS, XRD, and a wear and friction tester. The results show that there was an obvious boundary between the cladding coating and the substrate. The main phases were γ(Fe, Ni), WC, TiC, Cr2Ti, and Cr23C6. In the middle of cladding coating, the microstructure was composed of dendrite and cellular crystals, while the microstructure was composed of equiaxial crystals in the bonding region. Inside the cellular crystal, the main phase was γ~(Fe, Ni), which occasionally also showed the appearance of some white particles inside the cellular crystal. Compared with the cellular crystal, the boundary had less of the Fe and Ni elements and more of the Cr and W elements. The amount of C element around the dendrite crystal was more than that around the boundary of cellular crystal due to the long formation time of dendrite. The white particles around the boundary were carbides, such as WC and Cr23C6 phases. Meanwhile, the segregation of the Si element also appeared around the boundaries of the crystal. The maximum microhardness was 772.4 HV0.5, which was about 3.9 times as much as the substrate’s microhardness. The friction coefficients of the 45 steel substrate and Ni-based alloy coating were usually around 0.3 and 0.1, respectively. The Ni-based coating had a smaller coefficient and more stable fluctuations. The wear volume of the cladding coating (0.16 mm3) was less than that of the substrate (1.1 mm3), which was about 14.5% of the wear volume of 45 steel substrate. The main reason was the existence of reinforced phases, such as γ~(Fe, Ni), Cr23C6, and Cr2Ti. The added small WC and TiC particles also enhanced the wear resistance further. The main wear mechanism of the cladding coating was changed to be adhesive wear due to the ceramic particles, which was helpful in improving the service life of 45 steel.
Analysis of Efficiency Characteristics of a Deep-Sea Hydraulic Power Source
Authors: Li Donglin , Guo Fuhang , Xu Liping , Wang Shuai , Yan Youpeng , Ma Xianshuai , Liu Yinshui
Published: November 2023

Deep-sea submersibles carry limited energy sources, so a high efficiency of the equipment is required to improve endurance. In the deep-sea environment, the hydraulic power source is filled with oil, which causes structural deformation of the power source and changes in the physical properties of the medium, leading to unknown changes in the efficiency characteristics of the power source. In order to explore the efficiency characteristics of the deep-sea hydraulic power source composed of a gear pump and a DC (direct current) brushless motor in a variable sea depth environment, we undertook the following. First, considering the effects of seawater pressure and temperature on the physical properties of the medium and the radial clearance deformation of the gear pump, a mathematical model for the total efficiency of the hydraulic power source was established. The results indicate that the deformation of the pump body is mainly determined by the seawater pressure and working pressure. Subsequently, by analyzing the effects of the two factors on the efficiency of the power source, respectively, when the oil temperature range is large enough, the total efficiency of the power source will increase and then decrease under six sea depths; the total efficiency of the power source decreases with the increase in the rotational speed. However, in a land environment, the trend of the efficiency characteristics of the power source is opposite to that of the remaining six deep-sea environments, both in terms of oil temperature and rotational speed. Finally, the efficiency trend of the power source with changes in sea depth under rated conditions was obtained. Under different sea depth ranges, the optimal operating oil temperatures and suitable rotational speed ranges of the power source could be obtained. This paper could provide a certain theoretical basis for the research and development of deep-sea equipment.
Modeling of Junior Servers Approaching a Senior Server in the Retrial Queuing-Inventory System
Authors: Jeganathan Kathirvel , Harikrishnan Thanushkodi , Lakshmanan Kumarasankaralingam , Melikov Agassi , Sztrik Janos
Published: November 2023

This article deals with the queuing-inventory system, composed of c junior servers, a senior server, two finite waiting halls, and an infinite orbit. On occasion, junior servers encounter challenges during customer service. In these instances, they approach the senior server for guidance in resolving the issue. Suppose the senior server is engaged with another junior server. The approaching junior servers await their turn in a finite waiting area with a capacity of c for consultation. Concerning this, we study the performance of junior servers approaching the senior server in the retrial queuing-inventory model with the two finite waiting halls dedicated to the primary customers and the junior servers for consultation. We formulate a level-dependent QBD process and solve its steady-state probability vector using Neuts and Rao’s truncation method. The stability condition of the system is derived and the R matrix is computed. The optimum total cost has been obtained, and the sensitivity analyses, which include the expected total cost, the waiting time of customers in the waiting hall and orbit, the number of busy servers, and a fraction of the successful retrial rate of the model, are computed numerically.
Model Compression Algorithm via Reinforcement Learning and Knowledge Distillation
Authors: Liu Botao , Hu Bing-Bing , Zhao Ming , Peng Sheng-Lung , Chang Jou-Ming
Published: November 2023

Traditional model compression techniques are dependent on handcrafted features and require domain experts, with a tradeoff between model size, speed, and accuracy. This study proposes a new approach toward resolving model compression problems. Our approach combines reinforcement-learning-based automated pruning and knowledge distillation to improve the pruning of unimportant network layers and the efficiency of the compression process. We introduce a new state quantity that controls the size of the reward and an attention mechanism that reinforces useful features and attenuates useless features to enhance the effects of other features. The experimental results show that the proposed model is superior to other advanced pruning methods in terms of the computation time and accuracy on CIFAR-100 and ImageNet dataset, where the accuracy is approximately 3% higher than that of similar methods with shorter computation times.
Peak-to-Peak Stabilization of Sampled-Data Systems Subject to Actuator Saturation and Its Practical Application to an Inverted Pendulum
Authors: Nguyen Khanh Hieu , Kim Sung Hyun
Published: November 2023

This paper investigates the local stability and stabilization criteria of sampled-data control systems, taking into account actuator saturation and peak-bounded exogenous disturbances. Specifically, this study introduces two innovations to extend the maximum upper bound of the sampling interval: two novel time integrals of the weighted state derivative are introduced to formulate an improved looped-functional; second, the introduction of two supplementary zero-equalities to improve the relationship among the components of the augmented state. Building on this, a set of linear matrix inequality-based stabilization conditions is derived. These conditions ensure that a closed-loop sampled-data system can become exponentially stable and achieve a guaranteed peak-to-peak performance in the domain of attraction. Finally, the efficacy of the proposed methodology is substantiated through both simulation and experimental results, focusing on the sampled-data control of an inverted pendulum system.
Microstructural Evolution and Gas-Tight Properties of Yttria-Stabilized Zirconia/Crofer 22H Stainless Steel Brazed Joints with the Ag-Ge-Si Filler for Use in Solid-Oxide Fuel Cells
Authors: Huang Liang-Wei , Shiue Ren-Kae , Liu Chien-Kuo
Published: November 2023

In this paper, a novel 95Ag-2.5Ge-2.5Si (in wt %) filler is utilized for brazing yttria-stabilized zirconia (YSZ) electrolytes and commercial Crofer 22H interconnects for solid-oxide fuel cells’ (SOFCs) sealing application. Before brazing, surface metallization is applied on YSZ and Crofer 22H substrates to improve the wetting performance of the filler on YSZ and Crofer 22H substrates. The brazing procedure is performed at 900 °C for 10 min under a high vacuum (~10−6 torr) to prepare sandwiched YSZ/Crofer 22H brazed coupons. The metallization mentioned above can achieve reactive wetting toward YSZ ceramics. A Si/Ti-rich oxide layer and an Fe-Cr-Si alloying phase are formed at the brazed joints’ YSZ/filler and filler/Crofer 22H interfaces. After exposure to air at 750 °C for 100 h, Cu and Si contents suffer from oxidation and form CuO and SiO2, respectively, in the brazed zone and the YSZ/filler interface of the joints. The Fe-Cr-Si alloying phase at the filler/Crofer 22H interface is preserved without apparent oxidation. The pressure-drop test results show that the brazed joints’ gas tightness does not deteriorate significantly after thermal aging, which is attributed to the good interfacial integrity of thermal-aged joints.
The Influences of Micro-Alloying Element Sn and Magnetic Field on the Microstructure Evolution of Al–Bi Immiscible Alloys
Authors: Chen Shu , Jiang Hongxiang , Zhao Jiuzhou
Published: November 2023

An investigation was conducted through directional solidification experiments to explore the impact of micro-alloying element Sn and a magnetic field on the solidification behavior of immiscible Al–Bi alloys, as well as the combined effect of Sn and the magnetic field. Experimental results show that the size distribution of the dispersed particles in the low-speed solidified Al–3.4 wt.%Bi alloy presents two peaks, while it only shows one peak when solidified at a relatively high speed. The addition of Sn not only can enhance the nucleation rate and the number density of the Bi-rich droplets in the sample, but also decrease the Marangoni migration velocity and the axial resultant velocity of minority phase droplets in front of the solidification interface. Thereby it promotes the formation of Al–Bi alloys with a well-dispersed microstructure. A static magnetic field with the strength of 0.2 T increases the number density of the dispersed particles and decreases the average size and the size distribution width of the dispersed particles. Under the effect of Sn addition and static magnetic field, the average radius of the dispersed particles R and the solidification velocity V0 satisfy R∝V0−1/3 when the alloy was solidified at a relatively low velocity, R and V0 satisfy R∝V0−1/2 when the alloy is solidified at a high velocity.
Model of Pulmonary Co-Infection of Aspergillus and Pseudomonas in Immunocompetent Mice
Authors: Sass Gabriele , Stevens David A.
Published: November 2023

Co-infection with Pseudomonas (Pa) and Aspergillus (Af) commonly occurs in the airways of immune-compromised patients or in cystic fibrosis and frequently results in more severe outcomes than mono-infection. We affixed both pathogens to agar beads, separately (Af beads, Pa beads) or on the same bead (AfPa beads) and infected immunocompetent mice, an in vivo Af-Pa interaction model. Endotracheal administration was superior to intranasal, allowing larger beads to be administered resulting in longer lung residence. The CFU of the Af beads, diameter 150–250 µm, were detectable for ≤21 days. Af-bead-infected mice cleared the Af infection more than mice infected with AfPa beads, but Af clearance was the same with a combination of beads (Af beads + Pa beads). Pa-infected mice had more Pa clearance in the presence of Af than with Pa beads alone. In vitro studies supported our conclusion that the close proximity of Af and Pa (on AfPa beads) was disadvantageous for Af, whereas a larger distance (Af + Pa beads) was not. We demonstrated that the interaction between Pseudomonas and Aspergillus during co-infection can be studied in immunocompetent mice. The mutual inhibition of Af and Pa in vivo appears to be dependent on their proximity. We review the literature relating to animal models of infection with Af, Pa, or both.
A High-Efficiency Deep Blue Emitter for OLEDs with a New Dual-Core Structure Incorporating ETL Characteristics
Authors: Heo Yeongjae , Kwon Hyukmin , Park Sangwook , Dae Sunwoo , Lee Hayoon , Lee Kiho , Park Jongwook
Published: November 2023

In this study, we introduced the weak electron-accepting oxazole derivative 4,5-diphenyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazole (TPO) into both anthracene and pyrene moieties of a dual core structure. Ultimately, we developed 2-(4-(6-(anthracen-9-yl)pyren-1-yl)phenyl)-4,5-diphenyloxazole (AP-TPO) as the substitution on the second core, pyrene, and 4,5-diphenyl-2-(4-(10-(pyren-1-yl)anthracen-9-yl)phenyl)oxazole (TPO-AP) as the substitution on the first core, anthracene. Both materials exhibited maximum photoluminescence wavelengths at 433 and 443 nm in solution and emitted deep blue light with high photoluminescence quantum yields of 82% and 88%, respectively. When used as the emitting layer in non-doped devices, TPO-AP outperformed AP-TPO, achieving a current efficiency of 5.49 cd/A and an external quantum efficiency of 4.26% in electroluminescence. These materials introduce a new category of deep blue emitters in the organic light-emitting diodes field, combining characteristics related to the electron transport layer.
Applicability of Titanium-Based Catalysts in the Photocatalytic Degradation of 2,3,7,8-Tetrachlorodibenzofuran
Authors: Samara Fatin , Darra Rasha , Mohamed Ahmed A. , Ahmad Waqas , Abu-Farha Nedal , Lee Haesung , Han Changseok , Kanan Sofian
Published: November 2023

Polychlorinated dibenzofurans (PCDFs) are persistent toxic compounds that are ubiquitous in the environment. Nanocomposites of titanium(IV) oxide-vanadium(III) oxide (Ti3V2O7) and titanium(IV) oxide-silicon dioxide (Ti2Si7O30) were prepared and spectroscopically analyzed as potential decontaminants for dioxin-like materials. The analysis confirmed a homogeneous morphology with nanoscale particle size. The Ti-Si sample was found to have a high surface area compared to the Ti-V composite. Vanadium(III) oxide (V2O5) and silicon dioxide (SiO2) were chosen as materials for the formation of heterogeneous compounds with titanium(IV) oxide (TiO2) because they possess a suitable band alignment with TiO2, thus forming effective photocatalysts. This study evaluated the photodegradation of 2,3,7,8-tetrachlorodibenzo-furan (TCDF) in the presence of Ti-Si and Ti-V oxide composites, which was tested using high- (254 nm) and midenergy (302 nm) UV irradiation sources. While Ti-Si showed success in the photodegradation of 2,3,7,8-TCDF dissolved in a (1:1) methanol–tetrahydrofuran (MeOH-THF) solution, the Ti-V composite proved to be a powerful material in adsorbing TCDF with a high capacity immediately upon mixing. Ti-Si oxide was found to decompose TCDF under the two irradiation sources with 98–99% degradation occurring after 70 min. The use of 254 nm as an irradiation source in the presence of Ti-Si was 4.3 times faster than the analogue reaction irradiated without a catalyst. Byproducts of the degradation were evaluated using gas chromatography–mass spectrometry (GC–MS), resulting in a lower chlorinated congener and less toxicity, as the main degradation product.
A Holistic View of the Interactions between Electron-Deficient Systems: Clustering of Beryllium and Magnesium Hydrides and Halides
Authors: Mó Otilia , Montero-Campillo M. Merced , Yáñez Manuel , Alkorta Ibon , Elguero José
Published: November 2023

In the search for common bonding patterns in pure and mixed clusters of beryllium and magnesium derivatives, the most stable dimers and trimers involving BeX2 and MgX2 (X = H, F, Cl) have been studied in the gas phase using B3LYP and M06-2X DFT methods and the G4 ab initio composite procedure. To obtain some insight into their structure, stability, and bonding characteristics, we have used two different energy decomposition formalisms, namely MBIE and LMO-EDA, in parallel with the analysis of the electron density with the help of QTAIM, ELF, NCIPLOT, and AdNDP approaches. Some interesting differences are already observed in the dimers, where the stability sequence observed for the hydrides differs entirely from that of the fluorides and chlorides. Trimers also show some peculiarities associated with the presence of compact trigonal cyclic structures that compete in stability with the more conventional hexagonal and linear forms. As observed for dimers, the stability of the trimers changes significantly from hydrides to fluorides or chlorides. Although some of these clusters were previously explored in the literature, the novelty of this work is to provide a holistic approach to the entire series of compounds by using chemical bonding tools, allowing us to understand the stability trends in detail and providing insights for a significant number of new, unexplored structures.
Design, Synthesis and Bioactivity Evaluation of Heterocycle-Containing Mono- and Bisphosphonic Acid Compounds
Authors: Wu Xin , Yang Zili , Bu Mengwei , Duan Jiang , Zhang Aidong
Published: November 2023

Fosmidomycin (FOS) is a naturally occurring compound active against the 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) enzyme in the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, and using it as a template for lead structure design is an effective strategy to develop new active compounds. In this work, by replacing the hydroxamate unit of FOS with pyrazole, isoxazole and the related heterocycles that also have metal ion binding affinity, while retaining the monophosphonic acid in FOS or replacing it with a bisphosphonic acid group, heterocycle-containing mono- and bisphosphonic acid compounds as FOS analogs were designed. The key steps involved in the facile synthesis of these FOS analogs included the Michael addition of diethyl vinylphosphonate or tetraethyl vinylidenebisphosphonate to β-dicarbonyl compounds and the subsequent cyclic condensation with hydrazine or hydroxylamine. Two additional isoxazolinone-bearing FOS analogs were synthesized via the Michaelis–Becker reaction with diethyl phosphite as a key step. The bioactivity evaluation on model plants demonstrated that several compounds have better herbicidal activities compared to FOS, with the most active compound showing a 3.7-fold inhibitory activity on Arabidopsis thaliana, while on the roots and stalks of Brassica napus L. and Echinochloa crus-galli in a pre-emergence inhibitory activity test, the activities of this compound were found to be 3.2- and 14.3-fold and 5.4- and 9.4-fold, respectively, and in a post-emergency activity test on Amaranthus retroflexus and Echinochloa crus-galli, 2.2- and 2.0-fold inhibition activities were displayed. Despite the significant herbicidal activity, this compound exhibited a DXR inhibitory activity lower than that of FOS but comparable to that of other non-hydroxamate DXR inhibitors, and the dimethylallyl pyrophosphate rescue assay gave no statistical significance, suggesting that a different target might be involved in the inhibiting process. This work demonstrates that using bioisosteric replacement can be considered as a valuable strategy to discover new FOS analogs that may have high herbicidal activities.
Challenges and Opportunities in One Health: Google Trends Search Data
Authors: Wisnieski Lauren , Gruszynski Karen , Faulkner Vina , Shock Barbara
Published: November 2023

Google Trends data can be informative for zoonotic disease incidences, including Lyme disease. However, the use of Google Trends for predictive purposes is underutilized. In this study, we demonstrate the potential to use Google Trends for zoonotic disease prediction by predicting monthly state-level Lyme disease case counts in the United States. We requested Lyme disease data for the years 2010–2021. We downloaded Google Trends search data on terms for Lyme disease, symptoms of Lyme disease, and diseases with similar symptoms to Lyme disease. For each search term, we built an expanding window negative binomial model that adjusted for seasonal differences using a lag term. Performance was measured by Root Mean Squared Errors (RMSEs) and the visual associations between observed and predicted case counts. The highest performing model had excellent predictive ability in some states, but performance varied across states. The highest performing models were for Lyme disease search terms, which indicates the high specificity of search terms. We outline challenges of using Google Trends data, including data availability and a mismatch between geographic units. We discuss opportunities for Google Trends data for One Health research, including prediction of additional zoonotic diseases and incorporating environmental and companion animal data. Lastly, we recommend that Google Trends be explored as an option for predicting other zoonotic diseases and incorporate other data streams that may improve predictive performance.
Off-Label and Unlicenced Medicine Use among Hospitalised Children in South Africa: Practice and Policy Implications
Authors: Mathevula Hlayiseka , Schellack Natalie , Orubu Samuel , Godman Brian , Matlala Moliehi
Published: November 2023

Background: Information regarding off-label and unlicensed medicine use among South African children is limited. This is a concern as the prescribing of off-label and unlicensed medicines can lead to issues of effectiveness and safety as well as raise liability issues in the event of adverse events. This potentially exposes physicians to legal penalties. Consequently, we sought to determine the prevalence of off-label and unlicensed medicine use among paediatric patients in South Africa to provide future direction. Methods: This study retrospectively examined the use of medicine in a point-prevalence survey study (PPS) involving paediatric patients aged (0–2 years) admitted to selected public hospitals in Gauteng Province, South Africa. Data were collected per hospital over two days between February 2022 and July 2022. Demographics, duration of treatment, diagnosis, and medicines prescribed were collected from patient medical records using a mobile application. Prescribed medicines were reviewed against the medicine formularies and other databases to assess their appropriateness. Results: From three academic hospitals, 184 patient records were reviewed. A total of 592 medicines were dispensed, of which 379 (64.0%) were licensed and 213 (36.0%) were used off-label/unlicensed for paediatric patients 0–2 years of age. The most prevalent off-label and unlicensed medicines were multivitamins (n = 32, 15.0%) and ampicillin injections (n = 15, 7.0%). Conclusion: The frequency of unlicensed and off-label medicine prescribing shown in this study is consistent with the literature and can be considered high. This practice can pose a risk because it adversely affects patients if not properly regulated. Attention is needed to ensure future high-quality, safe, and effective use of medicines.
Evaluating the Response of Glycine soja Accessions to Fungal Pathogen Macrophomina phaseolina during Seedling Growth
Authors: Jacquet Shirley , Li Shuxian , Mian Rouf , Kassem My Abdelmajid , Rashad Layla , Viera Sonia , Reta Francisco , Reta Juan , Yuan Jiazheng
Published: November 2023

Charcoal rot caused by the fungal pathogen Macrophomina phaseolina (Tassi) Goid is one of various devastating soybean (Glycine max (L.) Merr.) diseases, which can severely reduce crop yield. The investigation into the genetic potential for charcoal rot resistance of wild soybean (Glycine soja) accessions will enrich our understanding of the impact of soybean domestication on disease resistance; moreover, the identified charcoal rot-resistant lines can be used to improve soybean resistance to charcoal rot. The objective of this study was to evaluate the resistance of wild soybean accessions to M. phaseolina at the seedling stage and thereby select the disease-resistant lines. The results show that the fungal pathogen infection reduced the growth of the root and hypocotyl in most G. soja accessions. The accession PI 507794 displayed the highest level of resistance response to M. phaseolina infection among the tested wild soybean accessions, while PI 487431 and PI 483660B were susceptible to charcoal rot in terms of the reduction in root and hypocotyl growth. The mean values of the root and hypocotyl parameters in PI 507794 were significantly higher (p < 0.05) than those of PI 487431 and PI 483460B. A analysis of the resistance of wild soybean accessions to M. phaseolina using the root and hypocotyl as the assessment parameters at the early seedling stage provides an alternative way to rapidly identify potential resistant genotypes and facilitate breeding for soybean resistance to charcoal rot.