bluuebunny/crossref_metadata_2025 huggingface dataset:
ANÁLISIS DE ZANJAS DE OXIDACIÓN COMO TECNOLOGÍA DE REMOCIÓN BIOLÓGICA DE NUTRIENTES EN EL ESTADO DE TABASCO
Authors: Martínez Rodríguez José Cruz , Rodríguez Rodríguez Ernesto
Published: November 2022

Actualmente el crecimiento demográfico y el desarrollo del sector industrial en nuestro país genera un incremento del volumen de aguas residuales, ante ello en algunos lugares de México se aplica la simple dilución en las aguas superficiales como medio para disminuir la carga de contaminantes. Considerando minimizar el impacto ambiental en los cuerpos receptores se requiere la implementación de un tratamiento biológico completo, que incluya la remoción biológica de nutrientes, incluso en comunidades pequeñas. Partiendo de la información disponible sobre las zanjas de oxidación, las dimensiones de este tipo de plantas, el número de canales empleados y su configuración, se compara con datos de población servida y el caudal de agua residual tratada. Se concluye así que dicha tecnología es viable en el trópico tabasqueño para el control de la eutroficación en los cuerpos de agua de tipo urbano.

Palabras clave: Zanjas de oxidación, configuración, diseño y operación.
SIMULACIÓN DE IMPACTO AMBIENTAL EN LA GERMINACIÓN DEL FRIJOL NEGRO (Phaseolus vulgaris L) CON DERRAMES DE HIDROCARBUROS
Authors: Calcáneo Gordillo Luis Alberto , Gómez Cruz Rodolfo , Gamboa Rodríguez María Teresa , Gamboa Aldeco Jesús Roberto
Published: November 2022

La creciente descarga de residuos industriales y domésticos, el derrame de hidrocarburos, así como de otros productos químicos ha generado serios problemas de contaminación en las aguas y esto requiere el uso urgente de metodologías adecuadas que permitan medir la naturaleza y mecanismos de los efectos de esos contaminantes sobre organismos vivientes. En este trabajo se realizó una simulación para determinar los efectos letales de los derrames de hidrocarburos en el Golfo de México que llegaron hasta los plantíos de frijol negro (‘Phaseolus vulgaris’ L). Se realizaron cuatro bioensayos bajo un diseño completamente al azar para probar las concentraciones de hidrocarburos al 100 %, 50 %, 10 %, 6 %, 5 %, 2 %, 1 % y 0.1 % en cada derrame; por otro lado, se llevó a cabo un control con tres repeticiones cada una con 5 o 10 granos de frijol negro por unidad experimental. A 72 h, la concentración letal media (CL50) de hidrocarburos por derrame fue 4 % (40,000 ppm) por ajuste de mínimos cuadrados y 3.1 % por el método Finney.

Palabras clave: Concentración letal, análisis Probit, hidrocarburos de derrame, frijol negro.
ANÁLISIS ECONÓMICO-FINANCIERO: A UN ACOPIO LECHERO EN LA REGIÓN MAYA DE CHIAPAS
Authors: Monroy Hernández Rubén , Brindis Santos Alfredo Isaac , Guevara Hernández Francisco , Coutiño Ruiz Roberto Reimundo , Lozano López Epifanía , Pimentel Segura Rafael
Published: November 2022

Los productores del Grupo Lechero Número Dos, de Punta Arena, Chiapas, se encuentran organizados pero con problemas en la gestión y asistencia técnica-administrativa, en consecuencia, desconocen su estado financiero y niveles de rentabilidad. La producción de leche en México es de suma importancia, debido a que en los últimos años el consumo en la población nacional no ha sido cubierto por la producción nacional, teniendo que importar leche de diferentes países, principalmente de Estados Unidos. Depender del comercio exterior pone en riesgo la seguridad alimentaria del país. El presente trabajo está basado en una propuesta creada por los productores del Centro de Acopio Lechero Número Dos de Punta Arena, Chiapas. Se genera a partir de necesidades puntuales de esta organización para conocer su estado financiero actual, lo cual detonará en la toma de decisiones, y así consolidar su integración con visión empresarial.

Palabras clave: Leche, rentabilidad, precios reales, producción, exportación, importación, demanda.
ESTIMACIÓN DE ENVASES MULTILAMINADOS UTILIZANDO UN ENFOQUE MULTICRITERIOS A NIVEL DE AGEB EN LA CIUDAD DE VILLAHERMOSA, TABASCO
Authors: López Méndez Arturo , González Villaseñor Áureo Enrique
Published: November 2022

La generación de residuos es un reflejo del costo ambiental muy alto, tanto para la naturaleza como para la sociedad misma; la variedad de materiales con los que se confeccionan los empaques y envolturas son diversos, aunque la predominancia está representada por el plástico, también se han usado recursos naturales como la celulosa que se obtiene de los árboles para la elaboración de envases. La propuesta que se establece en el presente proyecto de investigación es la de estimar la cantidad potencial de generación de este residuo realizando un análisis multicriterio a nivel del Área Geoestadística Básica (AGEB) considerando las variaciones en cada estrato socioeconómico a la vez que se prueban opciones de reciclaje mediante el sistema de prensado para la obtención de productos de fácil reutilización.

Palabras clave: Multilaminado, AGEB, Tetrapack, Elopack.
JOSÉ NARCISO ROVIROSA ANDRADE EN LOS ALBORES DE LA PRIMATOLOGÍA MEXICANA: DESCRIPCIONES PIONERAS DEL MÁS GRANDE NATURALISTA
Authors: Serio Silva Juan Carlos
Published: November 2022

Es muy probable que ningún naturalista haya contribuido al conocimiento de tantas disciplinas como fue el sabio Tabasqueño José Narciso Rovirosa. Sus aproximaciones pioneras en diversos campos de la zoología y la botánica han sido un parteaguas para el conocimiento y descripción de muchas especies. En particular sus relatos de campo sobre aspectos de la Distribución, Comportamiento, Amenazas y Conservación de las tres especies de primates nativos de México son notables, y constituyen quizás el precedente de cualquier estudio primatológico realizado en este país. Dado lo anterior, el presente estudio describe las anotaciones más relevantes de esas incursiones pioneras sobre los primates silvestres y sus preocupaciones, las cuales curiosamente lucen tan actuales como las mismas amenazas que el detectó y que siguen impactando la conservación de los monos Mexicanos.
CONMEMORACIÓN DEL 40 ANIVERSARIO DE LA BIOLOGÍA EN TABASCO: iniciando el grupo de zoólogos de la DACBiol
Authors: Trejo Pérez Juana Lourdes
Published: November 2022

Otra actividad que realizaba con mucho gusto era colaborar con el doctor Juan José Beauregard Cruz, quien en ese entonces, llevaba a cabo investigaciones con plantas acuáticas, ayudándole a identificarlas y hasta colectarlas.
CONMEMORACIÓN DEL 40 ANIVERSARIO DE LA BIOLOGÍA EN TABASCO: a Tabasco
Authors: Páramo Delgadillo Salomón
Published: November 2022

En uno de los primeros viajes, cuando decidimos regresar -casi anochecía y la gasolina se agotaba- un compañero comentó que había visto un lugar con tambos y seguramente vendían... para ese momento teníamos los brazos negruzcos por la cantidad de moscos que nos succionaban... ¡cosas que pasan!
EFECTOS DEL pH Y TEMPERATURA EN LAGUNAS DE ESTABILIZACIÓN DE UN CAMPUS UNIVERSITARIO
Authors: Guzmán Pérez Jennifer , Cruz Hernández Citlali Vianey , Torres Castro Pamela , Domínguez Rodríguez Verónica Isidra , Adams Schroeder Randy Howard , Baltierra Trejo Eduardo , Gómez Cruz Rodolfo
Published: November 2022

Las lagunas de estabilización son reactores bioquímicos complejos y representan una de las alternativas más viables para el tratamiento de aguas residuales en los campus universitarios, ya que requieren bajo costo de operación, poco mantenimiento y pueden usarse como biomaterial didáctico. Se monitoreó in situ la calidad del tratamiento de 106,020 m3/día de aguas residuales, por medio de la temperatura y el pH, a tres horas y profundidades diferentes, en el sistema de estabilización del campus de la División Académica de Ciencias Biológicas (DACBiol), de la Universidad Juárez Autónoma de Tabasco (UJAT), durante 30 días, en los meses de octubre y noviembre del 2019. Dadas las temperaturas máximas registradas de 28 °C y 26 °C en el afluente y efluente, respectivamente, y el pH máximo de 7.4 obtenido, en la laguna anaerobia-facultativa, tendiendo a ser ligeramente ácido por la mañana, este sistema de estabilización requiere mantenimiento para mejorar su eficacia.
Environmental Radioactivity Concentrations and Assessment of Radiological Hazards in Soil Around Bandung Nuclear Area
Authors: Chussetijowati Juni , Seno Haryo , Muliawan Dani
Published: November 2022

Bandung nuclear area is an area which is nuclear reactor named TRIGA 2000 and research laboratory located. The reactor and research laboratory are utilized for training, researching and radioisotopes production that has potential to contaminate the environment. Environmental radioactivity monitoring is done periodically to find out potential radioactive release from activities inside Bandung nuclear area to surroundings. However, the assessment of radiological hazards to determine the potential radiological dangers to humans and environment around Bandung nuclear area is not done yet. The objective of this study is assessing the radiological hazards in Bandung nuclear area by comparing the data from soil samples taken in environment radiological monitoring activity with the recommendation data based on UNSCEAR and other references to find out the radiological hazards that potentially affect to humans, where this assessment has never been carried out in this area. The assessment of radiological hazards in this study is limited to Ra-226, Th-232 and K-40 nuclides because contributing to radiation dose received by human. The study was conducted by collecting soil samples from several sampling points inside and outside Bandung nuclear area. Then, the nuclides of Ra-226, Th-232 and K-40 contained in soil samples are measured by using the gamma-ray spectrometry method with high resolution detector that is HPGe (High Purity Germanium) and a computer-based Multichannel Analyzer (MCA). The results indicated that the concentration of environmental radioactivity ranged between 11.02 to 32.66 Bq/kg for Ra-226; 19.44 to 43.83 Bq/kg for Th-232 and 56.00 to 183.39 Bq/kg for K-40. This study also obtained results that the radiological hazard of the gamma dose rate ranged from 23.54 to 40.23 nGy/h, the radium equivalent was 51.77 to 89.78 Bq/kg; the external hazard index was 0.14 to 0.24 and the internal from 0.18 to 0.33; the index of radioactivity level was 0.37 to 0.63. The annual effective dose equivalent for outdoor ranged from 0.03 to 0.05 mSv/y and indoor was 0.12 to 0.20 mSv/y. The lifetime cancer risk for outdoors ranged from 0.10x10–3 to 0.17x10–3 and indoor was 0.4x10–3 to 0.69x10–3. The values of radiological hazard were below the international requirements. There is no potential risk of natural radiation of gamma ionizing radiation exposure in soil samples around the Bandung nuclear area for workers, the public, and the environment.Keywords: Environment, Radiological, Hazard, Gamma, Spectrometry.
Analytical Methods for Mathematical Modeling of Dye-Sensitized Solar Cells (DSSCs) Performance for Different Local Natural Dye Photosensitizers
Authors: Yerima Jamu Benson , Ezike Sabastine Chinedu , William Dunama , Babangida Alkali
Published: November 2022

In this paper, a new approach to generate the modified ideal diode factor of solar cells was developed which overcomes the problem of assuming its value a constant. Five models were employed to calculate the five-model parameters of one standard solar cell and fourteen DSSCs with varying photosensitizers. The results exhibit the conversion efficiencies of the solar cells studied lies in the range 2.57% ≤ η ≤ 0.03%. In particular, the standard cell has the highest efficiency 3.02% followed by DSSCs with photosensitizers: bitter gourd (2.57%), mango (1%), and bougainvillea (0.83%). Also, the five model parameters calculated are all positive for El Tayyan model and the rest of the models show discrepancies of varying degrees. Furthermore, despite the existence of these discrepancies, the results reveal good fit between the model data and experimental data I-V curves. This suggests the tendency or possibility that irregular parameters may be desirable for some applications. Thus, the discrepancies found in the estimated parameters can serve as a vital assessment criterion and tool for researchers and engineers in selecting the appropriate parameter estimation method for their applications. Keywords: Analytical methods, Mathematical modeling, DSSCs, Photosensitizers, Irregular parameters, Conversion efficiency.
ENVIRONMENTAL ISSUES RELATED TO TIN MINING IN BANGKA BELITUNG ISLANDS
Authors:   Faculty of Law, University of Bangka Belitung, Bangka, Indonesia, Haryadi Dwi , Ibrahim Ibrahim ,   Faculty of Social & Political Sciences, University of Bangka Belitung, Bangka, Indonesia, Darwance Darwance ,   Faculty of Law, University of Bangka Belitung, Bangka, Indonesia
Published: November 2022

Massive tin mining in Bangka Belitung Islands significantly contributes to environmental issues, attracting media attention. For instance, several media continuously report environmental issues concerning tin mining with their respective perspectives. Therefore, this study aimed to describe and determine the news’ perspective concerning the tin mining conflict in Bangka Belitung Islands using a literature approach. This is with secondary data sources in the form of regulations and media record data. The results showed that the media attention in reporting on tin mining ranged from reclamation issues, regulations and policies, mining accidents, conflicts, impacts of tin mining, Corporate Social Responsibility (CSR), and law enforcement. This means that the media has not yet reached the investigative stage of discussing certain issues that need in-depth studies. Although the local media have covered various environmental issues, the coverage is only descriptive and not directed towards investigative environmental journalism.
POST-PANDEMIC TOURISM: OPPORTUNITIES FOR CREATIVE TOURISM
Authors:   CinTurs, Research Center for Tourism Sustainability and Well-being, University of Algarve, Faro, Portugal, Moreira Cabeça Sónia
Published: November 2022

Tourism was one of the most affected sectors by the outbreak of COVID-19 in early 2020 which had a devastating impact on the economy, and researchers are questioning the future of tourism in a post-pandemic world. In this exploratory text, based on a literature review, it is questioned if creative tourism can play a role in the rebuilding of the tourism industry, once it relies on place-based experiences that use local resources and involves communities and tourists in immersive activities. Creative tourism seems to be a response to the challenges, namely the tourists’ perception of physical distancing, the need to avoid over-tourism, mass tourism and touristification, the desire to reconnect with other people and to have enriching emotional experiences, the increase of awareness about sustainability (for places and future generations) and the resident’s needs and their living conditions. This paper relates the ongoing research on post-pandemic tourism, from several points of view – the tourist’s perceptions, the communities and territories’ needs, and the tourism planners’ vision… – with creative tourism, addressing the opportunities for such tourism, and questioning its feasibility and potential contribution to more meaningful tourism for both hosts and guests, to local economies grow, and to making tourism more sustainable.
EFFECT OF LANGUAGE! LIVE CURRICULUM ON U.S. MIDDLE SCHOOL STUDENTS’ LEXILE SCORES BASED ON GRADE LEVEL AND DIFFERENTIATED INSTRUCTION
Authors:   Ph.D., Department of Curriculum, Foundations, and Reading, Georgia Southern University, Statesboro, United States, Gutierrez de Blume Antonio P. , Soares Lina B. ,   Ph.D., Department of Middle Grades and Secondary Education, Georgia Southern University, Statesboro, United States, Snyder Ashley ,   Ed.D., Department of Middle Grades and Secondary Education, Georgia Southern University, Statesboro, United States
Published: November 2022

The purpose of the present investigation was to examine the effect of the Language Live! reading intervention on reading comprehension (Lexile level) in a sample of middle school students from the United States (N = 133) who were deemed ineffective readers. Students were either in the Strategic Group (i.e., reading comprehension below one grade level, n = 71) or the Intensive Group (i.e., reading comprehension below two grade levels, n = 62). Due to the severity of their reading difficulties, students in each group received a different reading curriculum. The grade x treatment type interaction was not significant. Nevertheless, the treatment type main effect suggested that students in the Strategic Group outperformed students in the Intensive Group regarding Lexile level proficiency, and the grade level main effect showed that the lowest Lexile level was evident in 6th grade while the highest was among 8th grade. Findings indicated the utility of the Language Live! educational intervention for struggling readers.
Project Activities of University Students as A Means of Achieving Learning Outcomes
Authors:   Bauman Moscow State Technical University (National Research Institute), Dvulichanskaya Natalia N. , Berezina Svetlana L. , Piasetsky Vyacheslav B.
Published: November 2022

Modern socio-economic conditions for the development of the Russian Federation have determined the requirements for the training of highly professional competitive specialists who must have not only professional knowledge and skills, but also a whole set of universal competencies that a person needs throughout his life for self-education, self-realization, change of occupation, productive professional and other activities. The article substantiates the relevance and need to organize project activities of students of a technical university as one of the innovative pedagogical technologies aimed at developing social and personal competencies, activating cognitive interests, and developing creative abilities. The authors analyze the essence of the method of project activity in education, emphasizing its problematic practice-oriented nature. Presented examples of projects completed by students of the Bauman Moscow State Technical University based as on the integration of knowledge in general subjects, so that disciplines of professional training; proposed a system of project evaluation criteria. Highlighted professional and universal competencies of students of a technical university which formed in the process of implementing practice-oriented projects of a problematic nature, and which facilitate the mobility of a university graduates in the labor market, their socialization in society.
Social Work: A Trajectory of Education and Employment
Authors:   Volga State University of Technology, Nizova Luidmila M. , Kislicyna Irina G.
Published: November 2022

The article explores the trajectory of education and employment of graduates in the direction of training specialists, bachelors and masters of social work. One of the main prerequisites for their preparation is the aging of the population and the decline in the number of people of working age. The dynamics of education in undergraduate and graduate programs over the past seven years, both in Russia and in the Mari El Republic is given. Based on a comparison of the educational trajectories of social work specialists, positive and negative factors are identified. The positive factors include the growth of the practical orientation of education, the mobility of graduates, the development of social partnership, the improvement of the composition of teachers and the improvement of technologies for the quality of education. Against this background, problems such as a weak scientific base in the constituent entities of the Russian Federation for the employment of postgraduates, low wages for social workers, a high level of aspirations of graduates, etc. have been identified. In order to improve the quality of education, the following measures have been proposed: state partnership, wider involvement of students in scientific research and grant activities, partnership in the field of joint laboratories and small enterprises for social assistance to lonely and elderly citizens on the basis of a social contract.
Student Family as an Object of Scientific Research (Review of Scientific Research on the Problems of Student Families)
Authors:   Institute for Demographic Research at the Federal research sociological center of the Russian Academy of Sciences, Rostovskaya Tamara K. , Knyazkova Ekaterina A. ,   Russian State University for the Humanities, Shirshova Tatyana M.
Published: November 2022

The purpose of the research is to study approaches to the concretization of the student family as an object of scientific research and policy pursued by the state, as well as to analyze available scientific research (on the problems of student families) and present them in chronological order, in retrospect. The methodological basis of the research consists of general logical methods (analysis, synthesis, induction), theoretical methods (the axiomatic method used by the authors in the analysis of historical sources; the historical method involving the study of the emergence and development of students and student families in chronological sequence), methods of sociological analysis of the functioning of the institute of student family. The results of the research. The review of scientific views on the evolution of the student family category, its functions and roles in society is presented. The prospects of the research are to use the materials obtained for a more in-depth study of the place and role of the student family in society at a certain stage of historical development.
Oxidation of sulfonamide micropollutants by versatile peroxidase from Bjerkandera adusta
Authors:   Instituto de Ciencias de la Benemérita Universidad Autónoma de Puebla. Edificio IC 8 Ciudad Universitaria. C.P. 72000, Puebla, México, Bairán Gabriela , Chávez-Bravo Edith ,   Instituto de Ciencias de la Benemérita Universidad Autónoma de Puebla. Edificio IC 8 Ciudad Universitaria. C.P. 72000, Puebla, México, Ortiz-Álvarez Jossue ,   Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala s/n. Col. Sto. Tomás, 11340 Ciudad de México, México., Romero-Guido Cynthia ,   Instituto de Ciencias de la Benemérita Universidad Autónoma de Puebla. Edificio IC 8 Ciudad Universitaria. C.P. 72000, Puebla, México, Torres Eduardo ,   Instituto de Ciencias de la Benemérita Universidad Autónoma de Puebla. Edificio IC 8 Ciudad Universitaria. C.P. 72000, Puebla, México
Published: November 2022

The oxidation of five sulfonamide antibiotics by the versatile peroxidase (VP, EC. 1.11.1.16) from Bjerkandera adusta was quantitatively assessed. The biocatalytic activity of the enzyme was studied by assaying different reaction conditions. Conversion levels were higher than 90 % for all five sulfonamide antibiotics in the model reaction system. In addition, the enzyme performance was also studied in treated wastewater effluents, where three sulfonamide antibiotics were oxidized at a higher level (greater than 85 % oxidation) and two were oxidized at a lower level (up to 50 %). The identified reaction products for two antibiotics, sulfasalazine, and sulfamethoxazole, showed higher antimicrobial activity than the parental compounds. Docking analyses exhibited that the reaction products interacted with the catalytic pocket of the dihydropteroate synthase from Escherichia coli, similar to the parental antibiotics. Though the oxidation is carried out at high velocity and conversion rates, the application of VP in the enzymatic oxidation technology of sulfonamide antibiotics must overcome the production of more toxic products.
Orange pigment variety in Black-bellied Crimson Finch Neochmia phaeton phaeton from West Kimberley, Australia
Authors:   Australian Wildlife Conservancy, P.O. Box 8070, Subiaco East WA 6008, Australia, Blondel Naomi , Kern Pippa ,   School of Biological Science, University of Queensland, St Lucia QLD 4072, Australia
Published: November 2022

During standardised bird surveys in September 2021 in the West Kimberly, two independent observations of an orange pigment variety in a male Black-bellied Crimson Finch Neochmia phaeton phaeton were recorded. This is the first documented observation of a wild Black-bellied Crimson Finch with this coloration.
Counting in Cycles
Authors: Javorszky Karl
Published: November 2022

Counting in terms of cycles allows modeling many processes of Nature. We make use of a slight numerical incongruence within the numbering system to find a translational mechanism which connects sequential ↔ commutative properties of assemblies. The algorithms allow picturing the logical syntax Nature uses when reading the DNA. Ordering a collection on two different properties of its members will impose two differing sequences on the members. The coordinates of a point on a plane of which the axes are the two sorting orders sidestep the logical contradiction arising from the different linear assignments. During a reorder, elements aggregate into cycles. Using an etalon collection of simple logical symbols (which are pairs of natural numbers), which we reorder, we see typical movement patterns along the path of the string of elements that are members of the same cycle. We split the {value, position} descriptions of a natural number and observe the places the unit occupies at specific instances of time among its peers, while being a member of a cycle, under different orders prevailing. Which places elements occupy among their peers, under specific order conditions, is determined by numeric properties of the natural numbers that make up the element. The model presented is therefore tautologic, and can be compared to a hybrid of sudokus with the ultimate form of Rubik‘s cube. It is necessary for the reader to do some self-education on the matter of cycles as a prerequisite to understanding the working principle of the model. The contraption being a new development, it can’t have references in literature.One cannot lose a bet on the idea that sorting and ordering a collection of elementary logical elements will turn up typical patterns and that these archetypes of patterns will be of interest to Theoretical Physics, Chemistry, Biology, Information Theory, and some other fields, too.
Synergistic Cooperation Involving TGFβ1-mediated Crosstalk Enhances the Invasiveness of Genetically Distant Cancer Clones
Authors: Carneiro Caroline S. , Hapeman Jorian D. , Nedelcu Aurora M.
Published: November 2022

Intratumour heterogeneity is often associated with poor response to treatment and bad prognosis. In addition to constitutive genetic/epigenetic sources, phenotypic and functional heterogeneity can reflect cell plasticity due to changes in gene expression patterns induced by signals from the tumour microenvironment or other cells. Positive interactions between cancer clones can increase their fitness and contribute to tumour growth, resistance to drugs and metastasis. Consequently, understanding the pathways involved in such behaviours is of great significance for cancer treatment. To explore if and how genetically distant clones can synergistically enhance each other's metastatic potential, this study used three (two breast and one lung) cancer cell lines with different aggressiveness levels. We found that (i) the conditioned media from the breast and lung aggressive lines induce mesenchymal features and increase the migration and invasion potential of the poorly metastatic breast line, and (ii) in both cases, this interclonal communication is based on the same soluble factor – namely, the tumour growth factor TGF-β1. Furthermore, when the two breast lines are mixed and co-cultured, the invasive potential of both lines is enhanced, and this outcome is dependent on the recruitment of the less aggressive clone into expressing a malignant phenotype. Based on our findings, we propose a two-tier model whereby highly metastatic clones can recruit weakly metastatic clones into acquiring an invasive phenotype, which in turn augments the invasion ability of the former (i.e., a “help me help you” strategy) through shared proteases and/or ECM remodelling. We suggest that such synergistic cooperation can easily emerge via cross-talk involving metastatic clones able to constitutively secrete signalling molecules that induce and maintain their own malignant state (i.e., autocrine/cell-autonomous signalling) and clones that have the ability to respond to those signals (i.e., paracrine/non-cell-autonomous signalling) and express a metastatic phenotype. Taking into account the lack of therapies to directly affect the metastatic process, interfering with such cooperative behaviours that tumour cells engage in during the early steps in the metastatic cascade could provide an additional strategy to increase patient survival.
The Role of Non-climate Data in Effective Climate Adaptation Planning: Lessons From Small French and American Cities
Authors: Lioubimtseva Elena , Da Cunha Charlotte
Published: November 2022

There is a growing consensus that to effectively adapt to climate change, cities need user-friendly tools and reliable high-resolution biophysical and socio-economic data for analysis, mapping, modeling, and visualization. This study examines availability of various types of information used in climate adaptation plans of 40 municipalities with population less than 300,000 people in the United and in France, probing into the choice and usage of relevant information by small municipalities. We argue that non-climatic spatial data, such as population demographic and socio-economic patterns, urban infrastructure, and environmental data must be integrated with climate tools and datasets to inform effective vulnerability assessment and equitable climate adaptation planning goals. Climate adaptation plans frequently fail to address the existing structural inequalities and environmental injustices in urban infrastructure and land use. Adaptation methodological approaches should be reassessed in the context of much needed societal transformation. Lessons learned from our studies offer valuable insights for potential development of the national and state-level climate adaptation information services for cities.
Anticancer and Cytotoxicity Enhancement Activity in Combination With Synthetic Drug and Ethanolic Extracts From Ficus religiosa (Peepal Tree) Used in Cancer Cell Line Culture (Breast Cancer)
Authors: Tak Paras , Suturiya Vishnu , Mehta Mayank R. , Vyas Grilesh
Published: November 2022

Herbs and Plants have been the most important form of medicine in India since ancient times. the plant kingdom is a goldmine of potential drugs and active molecules. Medicinal plants played a vital role in manufacturing human health and improving the quality of human life for thousands of years. During the last decade, the use of traditional medicine has expanded globally and gained popularity. Medicinal plants have healing properties due to the presence of various complex chemical substances of different compositions. Medicinal plants have served humans well as valuable components of medicines, flavorings, beverages, cosmetics, and dyes. Ficus religiosa is one of the medically important plants belonging to the family of Moraceae. It has been used broadly by Ayurvedic practitioners in India to treat various diseases. The present work is an endeavor to improve the effectiveness of synthetic drugs in combination with plant extracts.
Tissue Engineering for Gastrointestinal and Genitourinary Tracts
Authors: Elia Elissa , Brownell David , Chabaud Stéphane , Bolduc Stéphane
Published: November 2022

The gastrointestinal and genitourinary tracts share several similarities. Primarily, these tissues are composed of hollow structures lined by an epithelium through which materials need to flow with the help of peristalsis brought by muscle contraction. In the case of the gastrointestinal tract, solid or liquid food must circulate to be digested and absorbed and the waste products eliminated. In the case of the urinary tract, the urine produced by the kidneys must flow to the bladder, where it is stored until its elimination from the body. Finally, in the case of the vagina, it must allow the evacuation of blood during menstruation, accommodate the male sexual organ during coitus, and is the natural way to birth a child. The present review describes the anatomy, pathologies and treatments of such organs, emphasizing tissue engineering strategies.
Analysis of Charging Infrastructure for Private, Battery-electric Passenger Cars: Optimizing Spatial Distribution using a Genetic Algorithm
Authors: Fadranski Diego , Syré Anne Magdalene , Grahle Alexander , Göhlich Dietmar
Published: November 2022

To enable the deployment of battery-electric vehicles (BEV) as passenger cars in the private transport sector, a suitable charging infrastructure is crucial. In this paper a methodology for efficient spatial distribution of charging infrastructure is evaluated by investigating a scenario with a market penetration of BEVs of 100 percent (around 1.3 million vehicles). It aims towards the development of various charging infrastructure scenarios - including public and private charging - which are suitable to cover the charging demand. Therefore, these scenarios are investigated in detail with focus on number of public charging points, their spatial distribution, the available charging power and the necessary capital costs. For the creation of those charging infrastructure scenarios a placement model is developed. It uses the data of a MATSim (Multi-Agent Transport Simulation) traffic simulation of the metropolitan area of Berlin to evaluate and optimize different distributions of charging infrastructure. The model uses a genetic algorithm and the principle of multi-objective optimization. The capital cost of the charging points and the mean detour car drivers must cover additionally are used as optimization criteria. Using these criteria should lead to cost efficient infrastructure solutions which provide high usability at the same time. The main advantage of the method selected is that multiple optimal solutions with different characteristics can be found and suitable solutions can be selected by using other criteria subsequently. The optimized charging infrastructure solutions show capital costs between 624 and 2950 million euro. Users must cover an additionally mean detour of 254m to 590m per charging process to reach an available charging point. According to the results a suitable ratio between charging points and vehicles is between 11:1 and 5:1. A share of fast charging infrastructure (>50kW) of less than ten percent seems to be sufficient, if it is situated at main traffic routes and highly frequented places.
In Underweight Women, Insufficient Gestational Weight Gain is Associated with Adverse Obstetric Outcomes
Authors: Montvignier Monnet Alizee , Savoy Delphine , Preaubert Lise , Hoffmann Pascale , Bétry Cécile
Published: November 2022

The pre-pregnancy BMI and the gestational weight gain are two important determinants of pregnancy outcomes. The aim of this study was to determine obstetric outcomes associated with insufficient gestational weight gain in women with a pre-pregnancy BMI < 18.5 kg/m2. This study was based on observational routinely-collected data from a University Hospital Maternity. The participants were allocated to the group sufficient or insufficient gestational weight gain: ≥ 12.5 kg and < 12.5 kg respectively. Primary outcomes were the adjusted birth weight in percentiles (%) and the proportion of SGA newborns. Secondary outcomes were obstetric and perinatal outcomes. A total of 135 participants with a median age of 28±8 years were included. The adjusted birth weight in percentiles was significantly lower in the insufficient gestational weight gain group (27.2±45.4 vs 42.6±48.8 %; P<0.001). Moreover, the insufficient gestational weight gain is associated with a higher risk of SGA (28.1% vs 11.3%; P=0.017). Our study also showed increased risks of premature rupture of membranes, anaemia and intrauterine growth restriction in women with an insufficient weight gain. Future studies should explore the risk factors associated with insufficient weight gain, in order to develop specific care for underweight pregnant women.
Occupational Stress and Burnout among Intensive Care Unit Nurses during the Pandemic: A Prospective Longitudinal Study of Nurses in COVID and non-COVID Units
Authors: Saravanan Pratima , Nisar Tariq , Zhang Qian , Masud Faisal , Sasangohar Farzan
Published: November 2022

Intensive care nurses are highly prone to occupational stress and burnout, affecting their physical and mental health. The occurrence of the pandemic and related events increased nurses’ workload and exacerbated stress and burnout. We conducted a prospective longitudinal mixed-methods study with a cohort of nurses working in a medical ICU (COVID unit; n = 14) and cardiovascular ICU (non-COVID unit; n = 5). Each participant was followed for six 12-hour shifts. Validated questionnaires measured occupational stress and burnout prevalence. Wrist-worn wearable technologies recorded physiological indices of stress. Participants elaborated on the contributors to stress via post-study questionnaire. Data were analyzed using statistical and qualitative methods. Participants who cared for COVID patients at the COVID unit were 3.71 times more likely to experience stress (p < .001) in comparison to non-COVID unit participants. No differences in stress levels were found when the same participants worked with COVID and non-COVID patients at different shifts at the COVID unit. The cohorts expressed similar contributors to stress including communication tasks, patient acuity, clinical procedures, admission processes, proning, labs, and assisting coworkers. Nurses in COVID units, irrespective of whether they care for a COVID patient, may experience high occupational stress and burnout.
The Association between Non-Alcoholic Fatty Liver Disease and Dynapenia in Men Diagnosed with Type 2 Diabetes Mellitus
Authors: Bulur Atilla , Sivritepe Ridvan
Published: November 2022

Background: Dynapenia and non-alcoholic fatty liver disease (NAFLD) are common, especially in the middle and advanced-age diabetic male population. We aimed to examine the clinical features, NAFLD severity, and parameters associated with the presence of dynapenia in type 2 diabetes mellitus (T2DM) cases. Material and Methods: One hundred thirty-five male patients diagnosed with T2DM between 45 and 65 years of age were included. Patients were staged by ultrasonography according to NAFLD status. Results: There were significant differences in muscle strength, upper arm circumference, calf circumference, and up-and-go test scores between the NAFLD groups (p<0.001 for all). The frequency of dynapenia was lower, and arm and calf circumferences were higher in patients without NAFLD. The muscle strength, upper arm circumference, calf circumference, and up-and-go test scores were significantly lower in the dynapenic group compared to the non-dynapenic group (p<0.005 for all). The prevalence of dynapenia increased along with the increase in NAFLD stages (p<0.001). Conclusions: We detected a significant association between NAFLD and dynapenia in middle-aged men with T2DM. As muscle strength decreases, the amount of fat in the liver increases, and as the fat in the liver increases, muscle strength decreases.
Revisiting the Anti-cancer Toxicity of Clinically Approved Platinating Derivatives
Authors: Forgie Benjamin N. , Prakash Rewati , Telleria Carlos M.
Published: November 2022

Cisplatin (CDDP), carboplatin (CP), and oxaliplatin (OXP) are three platinating agents clinically approved worldwide for use against a variety of cancers. They are canonically known as DNA damage inducers; however, that is only one of their mechanisms of cytotoxicity. CDDP mediates its effects through DNA damage-induced transcription inhibition and apoptotic signalling. In addition, CDDP targets the endoplasmic reticulum (ER) to induce ER-stress, the mitochondria via mitochondrial DNA damage leading to ROS production, and the plasma membrane and cytoskeletal components. CP acts in a similar fashion to CDDP by inducing DNA damage, mitochondrial damage, and ER stress. Additionally, CP is also able to upregulate micro-RNA activity, enhancing intrinsic apoptosis. OXP, on the other hand, at first induces damage to all the same targets as CDDP and CP, yet it is also capable of inducing immunogenic cell death via ER stress and can decrease ribosome biogenesis through its nucleolar effects. In this comprehensive review, we provide detailed mechanisms of action for the three platinating agents, going beyond their nuclear effects to include their cytoplasmic impact within cancer cells. In addition, we cover their current clinical use and limitations, including side effects and mechanisms of resistance.
Impact of the COVID-19 on the Control of Diabetic Patients in Diabetic Retinopathy and its Screening
Authors: Romero-Aroca Pedro , Baget-Bernaldiz Marc , Sagarra Ramon , Hervas Esther , Blasco Reyes , Molina Julia , Moreno Empar F. , Garcia-Curto Egugeni
Published: November 2022

(1) Background: Diabetic retinopathy (DR) is a complication of diabetes mellitus (DM) and the COVID-19 pandemic has affected screening programmes. The aim of present study was to determine the impact of the COVID-19 pandemic on the screening of diabetes patients in our Health Care Area (HCA); (2) Methods: A retrospective study of patients with DM who had attended the DR screening programme between January 2015 and June 2022. We studied attendance, DM metabolic control and DR incidence. (3) Results: Screening for DR decreased in the first months of the pandemic. Incidence of mild and moderate DR remained stable throughout the study, and we observed a little increase in severe-DR, proliferative-DR and neovascular glaucoma, during 2021 and 2022. (4) Conclusions: The COVID-19 pandemic caused a reduction in the number of patients screened for DM, although its effect on DR seems limited, with a similar number of patients with DR throughout 2015 to 2022, despite the number of patients with severe-DR and proliferative-DR increased in 2021 and 2022.
Environmental Monitoring: Emphasis on Optical Waveguide and Fiber-Based Sensors: A Review
Authors: Butt Muhammad A. , Voronkov Grigory S. , Grakhova Elizaveta P. , Kutluyarov Ruslan V. , Kazanskiy Nikolay L. , Khonina Svetlana N.
Published: November 2022

Environmental monitoring is an important topic and serves a vibrant scientific role by revealing long-term trends that can lead to new knowledge and understanding. Globally, there is active development of photonic sensors incorporating multidisciplinary research. The ultimate objective is to develop small, low-cost, sensitive, selective, quick, durable, remote-controllable sensors that are resistant to electromagnetic interference. Different photonic sensor designs and advances in photonic frameworks have shown the possibility to realize these capabilities. In this review paper, the latest developments in the field of optical waveguide and fiber-based sensors which can serve for environmental monitoring are discussed. Several important topics such as toxic gas, water quality, indoor environment, and natural disaster monitoring are reviewed.
Sistem Pendukung Keputusan Penerimaan Bantuan Sosial Program Keluarga Harapan (PKH) dengan Menggunakan Metode Naïve Bayes Classifier (Studi Kasus di Balai Desa Bendungan Kraton Pasuruan)
Authors: Saputro Adimas Agung
Published: November 2022

Program Keluarga Harapan (PKH) adalah program pemberian uang tunai kepada Keluarga Miskin (KM) berdasarkan persyaratan dan kententuan yang telah di tetapkan dengan melaksanakan kewajibannya. Pemilihan warga penerimaan bantuan sosial di Desa Bendungan. Saat ini sering kali mengalami ketidaktepatan dalam menyeleksi warga yang mendapatkan bantuan sosial. Karena saat ini banyak warga mampu mendapatkan bantuan sosial yang mana seharusnya di berikan kepada warga yang kurang mampu untuk itu di perlukan pengelompokan berdasarkan warga mampu dan tidak mampu berdasarkan kriteria. Tujuan penelitian ini menyajikan implementasi metode Naïve Bayes Classifier pada penerimaan bantuan sosial program harapan di Desa Bendungan. Hasil penelitian menunjukkan bahwa penggunaan metode Naïve Bayes Classifier dengan data latih sebanyak 50 data dan data uji sebanyak 10 data mendapatkan hasil akurasi sebesar 80%. Dapat disimpulkan bahwa implementasi dari metode Naïve Bayes Classifier dalam penerimaan bantuan sosial mendapatkan tingkat akurasi cukup memuaskan.
Analysis of Threshold Angle Variations on The Quality of Finishing Free-form Surface in CNC Milling Process
Authors: Purnomo Dhika Aditya , Bisono Fipka , Indrawan Rizal
Published: November 2022

The machining process using a combination of steep and shallow strategy is the most widely used strategy for the finishing process on complex models that have many areas of steep walls and shallow floors. Using a single machining strategy on the entire model can lead to long machining times and poor surface finish quality. The steep and shallow strategy can efficiently detect parts of the model that have steep contours and those that have shallow contours. In other words, this strategy can analyze the model surface angle at runtime to identify and divide the machining zone based on the slope angle or commonly called the threshold angle. In this context, the selection of the threshold angle is very important when carrying out the finishing process on free-form surfaces to produce a good surface quality. This study was conducted to determine the optimum threshold angle that can produce the minimum surface roughness between steep areas and shallow areas. Threshold angles that were varied were 20°, 30° and 40°. Machining was carried out using Ballnose type cutting tools with a diameter of 6 mm. Then the stepover and stepdown is 0.1 mm for the finishing process on the surface of the propeller product made of Aluminum by using a CNC Milling machine. From the experimental results, the most optimum threshold angle is at an angle of 40° with an average roughness value in the steep area of 1.9 mm and in the shallow area of 1.3mm and a total average roughness of 1.6mm.
Analisa Kelayakan Investasi Saham Dengan Pendekatan Capm Dan Rvar (Studi Pada Perusahaan Otomotif Dan Komponen Di Bei Tahun 2014 – 2018)
Authors: Putri Khalifah Eka Yaniar
Published: November 2022

Tujuan dari penelitian ini adalah untuk membantu investor mengetahui saham mana yang menawarkan pengembalian terbaik untuk jumlah risiko yang minim. Metode deskriptif dengan pendekatan kuantitatif digunakan untuk melakukan penelitian ini dengan teknik Purposive sampling digunakan. Ada 10 perusahaan yang diambil dari 13 perusahaan otomotif dan komponen. Temuan metode CAPM mengungkapkan bahwa ada 2 perusahaan yang termasuk saham efisien yaitu BRAM dan MASA. Dari hasil metode RVAR ada 4 saham tertinggi yaitu BRAM, MASA, INDS dan ASII.