bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTASI PENDIDIKAN ANTI KORUPSI MELALUI PROGRAM PUSAT EDUKASI ANTI KORUPSI DI SEKOLAH DASAR
Authors: Dairani Dairani  , Fathorrahman Fathorrahman  , Faradilla Mutiara Nisa
Published: October 2022

Kasus korupsi di Indonesia kian hari semakin meningkat, dikutip pada Suarajakarta.id menyatakan bahwa  korupsi di Indonesia semakin memburuk hingga mencapai 58%  Hal tersebut menjadikan lambat tahun korupsi sebagai budaya di Indonesia dan akan sulit untuk diberantas. Dalam artikel ini akan membahas pengimplementasian pendidikan anti korupsi melalui program pusat edukasi antikorupsi di Sekolah Dasar. Dalam program pusat edukasi antikorupsi yang disediakan oleh pemerintah ini kepada sekolah dinilai cukup efektif dalam membantu pendidik melaksanakan pendidikan anti korupsi. Dengan adanya pendidikan anti korupsi melalui program ini diharapkan dapat menciptakan manusia yang memiliki akhlak yang baik, pengetahuan yang luas, kesadaran pada diri sendiri akan buruknya melakukan tindakan korupsi.
KONSEP PENGADAAN BARANG DAN JASA DI DESA
Authors: Fathorrahman Fathorrahman  , Dairani Dairani  , Ahmad Yunus
Published: October 2022

Pengadaan barang dan jasa di pemerintahan desa menjadi kegiatan yang rutin dalam setiap tahun anggaran. Kegitan rutinan yang diselenggrakan untuk segala kegiata pemerintahan di pemerintahan desa menjadi sangat urgen karena berbagai faktor. Salah satunya karena pagu anggaran dari APBN 2022 sangatlah besar. Pagu anggaran tersebut sebesar enam puluh delapan triluin (Rp 68 triliun). Dari pagu tersebut, terdapat porsi besar untuk kegiatan pengadaan barang dan jasa di pemerintahan desa. Adapun rumusan masalah dalam penelitian ini hendak mengkaji bagaimana konsep atau aspek hukum pengadaan barang dan jasa di pemerintahan desa. Metode yang digunakan adalah yuridis normatif. Dari penelitian ini, dapat diperoleh kesimpulan bahwa pengadaan barang dan jasa di pemerintahan desa berbeda dengan pengadaan barang dan jasa di pemerintahan seca umum. Dikecualikannnya pengadaan tersebut tentu meiliki implikasi hukum yang berbeda pula sehingga perlu dilakukan penelitian yang mendalam supaya para pemangku kebijakan di tingkat pemerintahan desa, tidak terjebak pada kasus-kasus hukum di kemudian hari.
MANAJEMEN SUMBER DAYA MANUSIA DI SEKOLAH DASAR ISLAM ABU DZAR KELURAHAN JOMBANG KECAMATAN CIPUTAT
Authors: Dalila Afif  , Evi Satispi  , Izzatusholekha  , Aldira Lindawati  , Dita Rahmaditiani Junaidi
Published: October 2022

Manajemen sumber daya manusia menjadi hal yang penting untuk dimiliki oleh setiap organisasi maupun perusahaan dalam berbagai bidang Baik buruknya kualitas sumber daya manusia juga merupakan faktor penentu kualitas organisasi tersebut. . Dalam bidang pendidikan, manajemen sumber daya manusia perlu melaksanakan fungsinya dengan baik agar dapat menghadirkan para guru, karyawan serta tenaga kependidikan yang berkualitas. Kualitas sumber daya manusia yang ada dalam suatu sekolah juga akan menghasilkan output yang berkualitas sesuai dengan visi sekolah. Manajemen sumber daya manusia di SDI Abu Dzar, Jombang, Tangerang Selatan menjalankan fungsinya melalui indikator perencanaan, rekrutmen dan seleksi, peningkatan kompetensi pegawai, pengembangan karir, penilaian kinerja, dan kompensasi. Pendekatan yang digunakan dalam penelitian ini yaitu kualitatif. Adapun implementasi manajemen sumber daya manusia di SDI Abu Dzar berdasarkan hasil analisis penelitian, sudah terlaksana dengan baik yang ditandai dengan terlaksananya fungsi manajemen sumber daya manusia. seperti adanya perencanaan, pengembangan karir, peningkatan kompetensi yang baik dan dalam hal kompensasi yang sangat menyejahterakan pegawai. Walaupun dari segi rekrutmen belum sesuai dengan ketentuan yang diakibatkan oeh beberapa factor, salah satunya banyaknya jumlah peserta didik baru yang tidak dapat diprediksi setiap tahunnya namun sedikitnya jumlah pelamar saat pembukaan rekrutmen guru. Maka itu dalam proses rekrutmen, jika ada yang tidak sesuai ketentuan masih bisa diberi kesempatan. Manajemen sumber daya manusia menjadi hal yang penting untuk dimiliki oleh setiap organisasi maupun perusahaan dalam berbagai bidang Baik buruknya kualitas sumber daya manusia juga merupakan faktor penentu kualitas organisasi tersebut. . Dalam bidang pendidikan, manajemen sumber daya manusia perlu melaksanakan fungsinya dengan baik agar dapat menghadirkan para guru, karyawan serta tenaga kependidikan yang berkualitas. Kualitas sumber daya manusia yang ada dalam suatu sekolah juga akan menghasilkan output yang berkualitas sesuai dengan visi sekolah. Manajemen sumber daya manusia di SDI Abu Dzar, Jombang, Tangerang Selatan menjalankan fungsinya melalui indikator perencanaan, rekrutmen dan seleksi, peningkatan kompetensi pegawai, pengembangan karir, penilaian kinerja, dan kompensasi. Pendekatan yang digunakan dalam penelitian ini yaitu kualitatif.
TATA KELOLA PERSIAPAN AKREDITASI SD ISLAM ASSALAF TAHFIDZUL QUR’AN
Authors: Aldira Lindawati  , Evi Satispi  , Izzatusholekha  , Dalila Afif  , Dita Rahmaditiani Junaidi
Published: October 2022

Penelitian ini bertujuan untuk mendeskripsikan: (1) proses pembentukan tim akreditasi sekolah, (2) pelaksanaan pengisian instrumen akreditasi dan bukti fisik, (3) faktor penghambat dan pendukung dalam persiapan akreditasi sekolah, (4) quality control dari proses pengisian instrumen akreditasi dan bukti fisik, (5) tindak lanjut persiapan akreditasi sekolah, dan (6) strategi keberhasilan dalam akreditasi sekolah. Penelitian ini menggunakan pendekatan kualitatif, dengan rancangan penelitian studi kasus. Lokasi penelitian di SD Islam As-salaf Tahfidzul Qur’an Serpong, Tangerang Selatan. Teknik pengumpulan data dengan wawancara, observasi, dan dokumentasi. Hasil penelitian ini (1) proses pembentukan tim melalui penunjukan ketua tim oleh kepala sekolah, (2) pelaksanaan pengisian instrumen akreditasi dan bukti fisik melalui menghadiri sosialisasi, melakukan checklist instrumen akreditasi, persiapan data akreditasi dan pemenuhan bukti fisik, (3) faktor penghambat yaitu belum adanya tenaga dibidang administrasi sekolah, keterbatasanya waktu, bukti fisik berupa dokumen yang letak nya tidak beraturan dan terkadang tidak adanya bukti berupa foto, fasilitas yang kurang memadai berupa printer, sedangkan faktor pendukung yaitu bantuan dan motivasi kepala sekolah, kerja sama antar tim, dan bantuan stakeholders sekolah (4) quality control melalui pengecekan dan rapat evaluasi, (5) tindak lanjut persiapan dengan membiasakan kelengkapan perangkat sekolah, membuat program sekolah, dan (6) strategi keberhasilan dalam akreditasi sekolah terdapat strategi untuk mendapatkan nilai A dan strategi supaya cepat selesai.
ANALISIS PERBANDINGAN PENDAPATAN PETANI KOPI PETIK MERAH SEBELUM DAN SESUDAH COVID-19 DI KECAMATAN KABAWETAN KABUPATEN KEPAHIANG
Authors: Rifki Kurniawan  , Febri Nur Pramudya  , Putri Milanda Bainamus
Published: October 2022

Penelitian Analisis Perbandingan Petani Kopi Petik Merah Sebelum dan Sesudah Covid-19 di Kecamatan Kabawetan Kabupaten Kepahiang bertujuan untuk menganalisis perbedaan antara pendapatan petani kopi petik merah sebelum dan sesudah Covid-19 yang ada di Kabupaten Kepahiang. Penelitian ini di lakukan pada bulan Maret tahun 2022 di Kecamatan Kabawetan Kabupaten Kepahiang dengan kelompok tani kopi yang terdapat di Kawasan Kabawetan. Analisis data yang di gunakan dalam penelitian ini adalah uji t untuk sampel berpasangan atau dengan istilah Paired Sampels T Test yang digunakan untuk mengetahui perbedaan rata-rata diantara dua sampel yang berpasangan. Uji Paired Sampels T Test ini digunakan terhadap 61 responden petani kopi yang ada di Kawasan Kabawetan.Berdasarkan uji paired sample t-tes dapat di lihat bahwa data variabel dari pendatan sebelum Covid-19 memiliki rata-rata 29.597.639,3607, standar deviasi 15.846.300,94802, standar kesalahan rata-rata 2.028.910,93186. Banyaknya sampel pada penelitian ini yaitu sebanyak 61. Pendapatan sesudah Covid-19 memiliki rata-rata 29.751.864,0164, standar deviasi 14.713.442,37945, standar kesalahan rata-rata 1.883.863,25534. Banyaknya sampel pada penelitian ini yaitu sebanyak 61. Hasil uji beda rata-rata menunjukan bahwa nilai signifikan pendapatan petani kopi petik merah sebelum dan sesudah pandemi Covid-19 adalah sebesar 0,822 atau lebih kecil dari 0,05 maka H0 : ditolak dan H1: diterima. Dan bisa di simpulkan terdapat perbedaan yang signifikan antara pendapatan petani kopi petik merah sebelum dan sesudah pandemi Covid-19.
ANALISIS USAHA KOPI BUBUK CAP AA DI KELURAHAN SIDOREJO KECAMATAN CURUP TENGAH, KABUPATEN REJANG LEBONG
Authors: Dwan Pramadani Hidayat  , Dwita Frisdinawati  , Mira Yanuarti
Published: October 2022

Research on Business Analysis of Cap AA Powdered Coffee in Sidorejo Village, Central Curup District, Rejang Lebong Regency aims to find out how much the production cost of Cap AA ground coffee in Sidorejo Village, Central Curup District, Rejang Lebong Regency, how much revenue and income is obtained and whether the business is The production of Cap AA ground coffee in Sidorejo Village, Central Curup District, Rejang Lebong Regency is efficient. This research was conducted in May 2021 – June 2021 in the Cap Cangkir AA ground coffee industry in Sidorejo Village, Central Curup District, Rejang Lebong Regency. The data analysis method used is cost analysis, revenue, income, R/C Ratio. The cost incurred in the AA stamped coffee powder business is Rp. 29,677,373/month or Rp. 1,978,492/ production. The total revenue from the Cap AA Coffee Powder business is Rp. 37,200,000 per month or an average of Rp. 2.480,000 per production, during the study period with a total operating income of Rp. 7,522,622 per month or an average of Rp. 501,508 per production. The results of the calculation of the R/C Ratio analysis show that the R/C ratio is 1.25. This means that each expenditure of Rp. 1.00 it will generate income of Rp. 1.25. Based on the R/C ratio value obtained with a value of more than 1, it can be said that Mr. Seno's AA powder coffee business is efficient and profitable.
ANALISIS DAMPAK KEBIJAKAN PEMBERLAKUAN PEMBATASAN KEGIATAN MASYARAKAT (PPKM) BAGI PELAKU USAHA BISNIS COFFEE SHOP DI KABUPATEN REJANG LEBONG
Authors: Cindy Claudia Utami  , Dodi Aprianto  , Mira Yanuarti
Published: October 2022

Based on the output of "Test Statistics", it is known that Asymp. Sig (2-tailed) feasible 0.012 is smaller than <0.05, it can be said that there is an average difference between before and before the PPKM Impact, then the key H0 is rejected and H1 is accepted. In the statistical table, the calculated Z value is -2.527, while the Z table value with an alpha of 5% or 0.05 is 1.96. While the Asymp value. Sig (2 tailed) was obtained 0.012 because Z count < Z table, namely -2.527 < 1.96 or a significance value of 0.012 <0.05 according to the statistical test used, then H0 was rejected and H1 was accepted.

Based on the output of "Test Statistics", it is known that Asymp. Sig (2-tailed) is feasible 0.011, smaller than <0.05, it can be said that there is an average difference that occurs at the Business Coffee Shop between before and before, it can be said that H0 is rejected and H1 is accepted. In the statistical table, the calculated Z value is -2.539, while the Z table value with an alpha of 5% or 0.05 is 1.96. While the Asymp value. Sig (2 tailed) is obtained 0.01 because Z count < Z table is -2.539 < 1.96 or
PERBAIKAN DAN PEMELIHARAAN MOTOR LISTRIK PENGGERAK WATER JET PUMP DI AREA WASTE HEAT RECOVERY SYSTEM PT CEMINDO GEMILANG
Authors: Feri Febrian Syah  , Endi Permata
Published: October 2022

Electricity is one of the vital needs that is indispensable for all humans and other places, one of which is PT. Cemindo Gemilang, engaged in the cement-producing industry, requires a huge electricity capacity. To reduce or reduce the cost of electrical energy, a power plant unit and a WHRS (waste heats recovery system) were made to supply electrical energy to the cement plant area. PT. Cemindo Gemilang and the Power Plant rely heavily on electric motors, almost all of which operate using electric motors. The electric motor is a single-phase or three-phase type with a voltage of 11 KV, 6.6 KV or 400 volts. When all generating units operate, all electric motors that play an essential role will continue to be active so that damage is often caused by operation and service life therefore in the power plant department, and there is an electrical and mechanical maintenance division to maintain the continuity of the power plant operational system. This study's aim 1). Explain about electric motors, 2). Explain the definition of the water jet pump, 3). Explain how the water jet pump works 4). Explain the components used in electric motors and their repair and maintenance.
MODEL ORNAMEN ARSITEKTURAL BIOMIMIKRI SEBAGAI RESPON PERUBAHAN IKLIM DALAM ARSITEKTUR BERKELANJUTAN
Authors: Dino Ramandha Ashari
Published: October 2022

Perubahan iklim membawa dampak terhadap semua lapisan kehidupan manusia. Perubahan iklim secara langsung atau tidak langsung merubah lingkungan fisik manusia di mana mereka tinggal dan melakukan kegiatan kesehariannya. Perubahan iklim juga memberikan dampak terhadap perubahan parameter iklim (suhu udara, suhu radiasi, kelembaban, kecepatan angin) kota, kawasan di sekitar bangunan, serta parameter iklim di dalam bangunan itu sendiri. Dalam pencapaian kenyamanan fisik manusia, suhu udara luar yang tinggi perlu diselesaikan dengan rancangan bangunan dengan pertimbangan parameter iklim sehingga perlu kiranya untuk segera dimodifikasi. Bangunan diciptakan untuk melindungi penggunanya dari bahaya yang berasal dari alam. Dengan demikian, dalam mendesain sebuah bangunan, penting untuk banyak belajar dari alam, Cabang ilmu pengetahuan ini muncul disebut "Biomimikri" yang berarti (Simulasi Alam) adalah metode inovasi yang mencari solusi berkelanjutan dengan meniru pola alam. Paper ini memberikan gambaran contoh model ornament arsitektural Biomimikri dalam bangunan guna merespon perubahan iklim yang terjadi, agar kebutuhan kenyamanan fisik manusia tetap tercapai, dan permasalahan pemanasan bumi dapat diminimalkan.
Penerapan Data Mining Klasifikasi C4.5 dalam Menentukan Tingkat Stres Mahasiswa Akhir
Authors: Anggi Trifani  , Agus Perdana Windarto  , Hendry Qurniawan
Published: October 2022

Penelitian ini bertujuan untuk melakukan Klasifikasi dalam menentukan tingkat Stres yang dialami oleh Mahasiswa Akhir di STIKOM Tunas Bangsa dengan menggunakan teknik data mining C4.5. Dengan mengetahui stres mahasiswa, pihak kampus dapat memberikan treatment dan perlakuan yang tepat terhadap mahasiswa akhir. Sumber data penelitian diperoleh dari beberapa kelas semester 6 dan 8 sebanyak 110 mahasiswa, melalui wawancara dan pembagian kuesioner. Atribut yang digunakan sebagai parameter penilaian untuk mengetahui tingkat stres yang dialami oleh mahasiswa akhir di STIKOM Tunas Bangsa, Pematang siantar antara lain: Interpersonal (C1), Intrapersonal (C2), Akademik (C3) dan Lingkungan (C4). Proses pengujian penelitian ini  menggunakan bantuan software RapidMiner untuk membuat pohon keputusan. Dari hasil pengolahan C4.5 dengan menggunakan bantuan software RapidMiner atribut Interpersonal (C1) menjadi atribut yang paling berpengaruh terhadap tingkat stres Mahasiswa Akhir dan data performance yang ditunjukkan terhadap kesesuaian metode C4.5 akurasinya adalah 87,88%.
ANALISIS MODEL BUDAYA PADA FILM DOKUMENTER KAMPOENG KUNYIT SUTRADARA DWI CHITA SUCI MELALUI MISE EN SCENE
Authors: Dani Manesah  , Aji Purnomo
Published: October 2022

Judul penelitian ini adalah Analisis Model Budaya Pada Film Dokumenter Kampoeng Kunyit Sutradara Dwi Chita Suci. Film adalah suatu bentuk seni yang mengandung informasi dan hiburan Ini berisi representasi atau makna dari apa yang ditampilkan. Penelitian ini bertujuan untuk merepresentasikan atau memaknai budaya lokal Melayu yang terdapat pada film Kampoeng Kunyit melalui mise en scene yang menampilkan budaya Melayu. Jenis pendekatan penelitian yang penulis gunakan dalam penelitian ini adalah metode kualitatif  dan menggunakan analisis isi berdasarkan model budaya Edgar H. Schein. Edgar H. Schein membagi model budaya ini menjadi dua kategori, seperti Budaya Benda dan budaya bukanlah benda. Sementara hasil penelitian ini menunjukkan adanya bahwa pada film documenter Kampong Kunyit Sutradara Dwi Chita Suci   ditemukan adanya representasi dua tanda kebudayaan antara lain: (a) budaya dan seni (b) bahasa (c) kekayaan budaya yang terdiri dari makanan Minuman lokal (papeda dan sopi) dan budaya tak berwujud, yaitu: (a)kepercayaan/ritual tradisional (b) hubungan pribadi.
PERANCANGAN IKLAN LAYANAN MASYARAKAT PEMBUATAN MEDIA TANAM DENGAN MEMANFAATKAN BARANG-BARANG BEKAS
Authors: Suprianingsih Suprianingsih  , Desipriani Desipriani
Published: October 2022

Public service advertisement is an extension or socialization made to provide information or education to the public about something that is beneficial to the community, both financially and non-financially. Planting media is a container or place to grow plants, both flowers, fruits and vegetables. Used goods are items that are no longer used, such as drink bottles, broken buckets and others, used goods are often considered as household waste that will be just thrown away. This public service advertisement is designed to educate the public to be able or willing to manage household waste produced into new goods that have artistic value and selling value.
Pelatihan Pemanfaatan Google Classrom Sebagai Media E-Learning Sekolah
Authors: Tri Hastono  , Ari Kusuma Wardana  , Firdiyan Syah  , Gunawan Gunawan  , Ramdan Harjana
Published: October 2022

The use of information technology in the world of education looks better. With the ease of getting this information, cases of parents who do not know the status of their children's education are increasingly rare. The use of technology in the world of education in teaching and learning activities cannot be done by one party alone. It takes the involvement of all, especially teachers and students. If you look at the age of the teachers, of course, not a few of them can be considered old. This is what makes not a few of the teachers still rigid with technology. But it's a different story with today's school students. The year of birth of school students is currently in the generation Z category, where technology is their lifestyle. The method of transferring knowledge from teachers to students must be changed so that knowledge can be well absorbed by students. This community service aims to provide training on the use of Google Classroom as one of the school's e-learning at SMP N 2 Kasihan.
ASISTENSI PENANGANAN DAN PENCEGAHAN STUNTING DI DESA DAMARKASIYAN KECAMATAN KERTEK KABUPATEN WONOSOBO
Authors: Muhammad Saefullah  , Robingun Suyud El Syam
Published: October 2022

Based on World Bank data, the stunting rate of the workforce in Indonesia reaches 54%, so it takes the role of all parties to succeed in the government's program to reduce the stunting rate. Through the assistance for handling and preventing stunting, the thematic Community Service Lecture (KPM) program based on the 2022 Al-Qur'an Science University in Damarkasiyan Village, it was concluded: that the assistance for stunting handling and prevention in Damarkasiyan Village was well received by the community. This activity raises awareness of citizens to live healthy and comply with recommendations from related parties.
Edukasi tentang Pentingnya Menjaga Lingkungan dan Perilaku Masyarakat Dengan Kejadian Demam Berdarah Dengue (DBD)
Authors: Momen Amalia  , Nursapriani Nursapriani
Published: October 2022

Penyakit Demam Berdarah Dengue (DBD) ditemukan hampir di seluruh belahan dunia terutama di negara-negara tropik dan subtropik. Masalah Demam Berdarah Dengue (DBD) di Indonesia merupakan salah satu masalah kesehatan yang cenderung meningkat jumlah penderita serta semakin luas penyebarannya sejalan dengan meningkatnya mobilitas dan kepadatan penduduk. Metode yang digunakan pada penyuluhan ini yaitu metode ceramah dengan media yang telah  disediakan yaitu leaflet yang akan kami bagikan kepada peserta penyuluhan. Untuk melihat pemahaman peserta terkait tema yang kami bawakan kelak maka kami akan memberikan kuesioner sebelum penyuluhan (pre) dan sesudah penyuluhan (post). Dari hasil kegiatan penyuluhan kepada masyarakat ini dapat ditarik kesimpulan bahwa hasil pengetahuan dan sikap menunjukkan hasil yang berbeda dimana untuk pengetahuan ada perbedaan sebelum dan sesudah penyuluhan sedangkan sikapnya tidak ada perbedaan sebelum dan sesudah penyuluhan.
STRATEGI PENGELOLAAN DANA ZAKAT, INFAQ DAN SEDEKAH (ZIS) PADA UPZ KECAMATAN DUKUN KABUPATEN GRESIK
Authors: Robbah Khunaifih  , M. Masrur Huda Asjhadi  , Duta Bintan Fitriyah  , Nailis Sa’adah
Published: October 2022

Management of zakat funds requires an institution that handles it in a professional, trustworthy and accountable manner, starting at the central level to the regional level (read: at the lower level it is called UPZ). UPZ (Zakat Collector Unit) is an institution that collects as well as distributes or distributes zakat, formed and officially issued by the local regional BAZNAS. The purpose of its establishment is in accordance with the mandate of Law No.23 of 2011 concerning zakat, namely by becoming UPZ BAZNAS, UPZ operations have been standardized according to the principles of proper zakat management. The services provided by UPZ BAZNAS are more optimal with the authority to provide Evidence of Zakat Deposit (BSZ) printed by BAZNAS. The BSZ can be used as evidence that the zakat paid can be calculated as a deduction from taxable income (zakat as deductible items).
One area in East Java in Gresik Regency, Dukun District, has formed a UPZ which is coordinated by the Dukun District UPZ Coordinator who oversees several UPZs, be it Village UPZ or Mosque UPZ and Taklim Assembly UPZ. The existence of the UPZ Coordinator is quite effective in coordinating the management of Zakat, Infaq and Shodaqoh (ZIS) for Muzakki (Zakat Givers), or Mustahik (Zakat Recipients) and Munfiq (Shodaqoh Givers).
The potential of ZIS in Dukun Subdistrict, Gresik Regency is quite high, both from the trade, agriculture or animal husbandry sectors as well as from the professions through Professional Zakat. From the early 2017 formation of UPZ until 2021, there was a significant increase. From simply recording ZIS acquisitions to making direct deposits to BAZNAS Gresik, the nominal amount of potential starts from the acquisition of 800 million rupiah to more than 3.5 billion in 2021. This is none other than community participation after going through education and socialization from the Coordinator UPZ either through official or non-official forums such as Friday Khutbah, Tarawih Kultum or existing Taklim Assembly activities.
Konseling tentang Diabetes Melitus Gestasional dan Pemeriksaan Glukosa di Puskesmas Tanralili
Authors: Nur Ismi Wahyuni  , Ekayanti Ekayanti
Published: October 2022

Gestational diabetes mellitus (GDM) is a glucose tolerance disorder that was first discovered during pregnancy which had never been diagnosed with diabetes in the mother and then showed high glucose levels during pregnancy. Women with GDM almost never give complaints even though the incidence of GDM can be threatening and very dangerous because it can cause several complications during pregnancy, childbirth and after childbirth is also one of the causes in cases of maternal and infant mortality. Pregnancy accompanied by diabetes is also at risk of causing maternal death up to 4 times 2. One other prevention that can be done is more intensive counseling and counseling from officers to all pregnant women about the description of the incidence of DMG.

This activity was carried out at the Tanralili Public Health Center with the method of individual counseling to pregnant women in turn with brochures distributed to each pregnant woman, after which they took blood/glucose checks while. This activity was attended by 2 lecturers and 2 midwifery students as well as 20 pregnant women.

This community service provides good benefits, namely getting knowledge about Gestational Diabetes Mellitus and being able to know glucose levels in the blood as screening so that it can prevent and detect early complications that will occur.
PELATIHAN PENGOLAHAN JAMBU KRISTAL UNTUK MENINGKATKAN EKONOMI MASYARAKAT DESA RINGIN TUNGGAL KECAMATAN GAYAM BOJONEGORO
Authors: Zumrotus Sa’diyah  , Farida Isroani
Published: October 2022

The current state of the war against COVID-19 requires people to be active at home, keep their distance, wear masks and other healthy living habits. Almost all activities that we normally can do outside the home freely, such as school, work, play, lectures and others, have been restricted since the Covid-19 outbreak. On the other hand, of course, there are economic factors that make people continue to do activities outside the home. Seeing this situation, the acceleration of handling COVID-19 must be carried out thoroughly and involve all parties who take universities.

In Ringintunggal village, residents work as farmers, usually growing rice, beans, soybeans, secondary crops, and others. But here there are also lots of crystal guavas owned by residents, so don't be surprised if we enter Ringintunggal village there will be lots of guava trees around people's homes, and there are several crystal guava gardens that are quite wide owned by residents. But with the abundance of guava fruit, it is not accompanied by the innovation of processed crystals. Therefore we saw that this was a problem in the village and we were moved to take action for the residents of Ringintunggal village by providing understanding and training on the potential assets owned by Ringintunggal village.
Sosialisasi Memotivasi Minat Belajar dalam Perkembangan Peserta Didik Usia 5 dan 6 Tahun dengan Media APE (Alat Permainan Edukatif) di TK Darul Falah Samarinda Utara Tahun 2019
Authors: Euis Kusumarini  , Andi Aslindah
Published: October 2022

Alat  Permainan  Edukatif  (APE)  diharapkan  agar  proses  pembelajaran menjadi menarik dan menyenangkan sehingga anak betah,tidak merasa bosan dan fokus dalam belajar. Walaupun telah diketahui bahwa Alat Permainan Edukatif (APE) sangat menunjang bagi terlaksananya proses belajar yang efektif namun perlu mengkreatifitaskan lebih banyak variasi di sekolah dalam menggunakan Alat Permainan Edukatif (APE) secara maksimal dalam proses pembelajaran. Tujuan kegiatan ini adalah untuk menumbuhkan  minat  belajar  anak, pengabdi akan menerapkan suatu tindakan dalam bentuk penggunaan media Alat Permainan Edukatif (APE) disiapkan oleh guru sesuai dengan kebutuhan pokok bahasan yang akan diajarkan pada anak dan didapat dengan mudah bisa gunakan bahan dari tersedia dibeli, barang bekas ataupun dalam bentuk kreatifitas lain yang bisa dibentuk, dibuat, digunakan dan dimanfaatkan terutama guru memiliki keahlian  keterampilan untuk hal tersebut perlu membekali diri dari sosialisai, pelatihan dan seminar  untuk belajar lagi dan memuntut hal baru dari ilmu pengetahuan dan keterampilan. Berdasarkan hasil dari sosialisai tersebut adalah berjalan dengan lancar dan tercapainya salah satu cara pilihan  untuk  dapat  membantu  dan  saling memberikan kebermanfaatan bersama dalam kemajuan dibidang pendidikan anak usia TK terutama usia 5 sampai 6 tahun dalam memotivasi mereka selain guru, peserta didik juga pihak lain yang berkepentingan dalam memajukan dunia pendidikan agar anak anak yang merupakan bagian dari nantinya sebagai penerus bangsa merupakan anak anak yang cerdas selain kognitifnya, keterampilannya juga prilaku serta wawasan dan pengembangan dirinya yang dimiliki berguna dan bermanfaat kelak nantiya baik bagi dirinya orang lain lingkungan dan negara tentunya.
PENGUATAN MANAJEMEN ORGANISASI DAN LEADERSHIP PADA MAHASISWA
Authors: Atika Riasari
Published: October 2022

Manajemen menjadi pemegang fungsi strategis bagi keberlangsungan hidup sebuah organisasi dan secara substansi manajemen sesungguhnya terletak pada pemimpin. Menjadi hal penting adanya pemimpin dalam organisasi agar tujuan organisasi tercapai, menjaga kelangsungan hidup dan perkembangan organisasi. Oleh karena itu melalui kegiatan pemaparan materi tentang manajemen organiasai dan kepemimpinan pada organisasi kemahasiswaan dapat meningkatkan pemahaman pentingnya pengelolaan organisasi yang baik dan pemimpin yang bisa menjadi sosok yang menjadi teladan panutan bagi yang dipimpinnya dan berhasil mencapai tujuan organisasi.
PEMBINAAN AKHLAK PADA ANAK USIA DINI MELALUI METODE PEMBIASAAN DALAM PEMBELAJARAN PENDIDIKAN AGAMA ISLAM
Authors: Muhammad Ibnu Faruk Fauzi
Published: October 2022

Habituation in education is very much needed because psychologically, students model more behavior or figures they idolize, including their teachers. Habituation is also no less important in learning activities. This is because any knowledge or behavior gained by habituation will be very difficult to change or eliminate it so that this method is very useful in educating children. Moral development activities for students are carried out at Dharma Wanita Sumberrejo Kindergarten through the habituation method of learning Islamic Religious Education (PAI). The research method used is a service method that describes the phenomenon that occurs as it is, data sources are obtained through school leaders, teachers and parents of children. The analysis is carried out with reference to the stages of tabulation, coding and giving meaning to the data. The results of the service show that the implementation of child moral development through the habituation method already contains the main teachings of Islam, namely Akidah (faith), Sharia (Islamic) and Akhlak (Ihsan). The method of habituation given by means of getting used to the behavior or moral attitude of the child repeatedly and continuously. In addition to the habituation carried out by teachers in schools, the role of parents is actually important for children's habituation in practicing Islamic teachings that have been taught through habituation in schools, but this role will not be maximized when parental involvement is not full on the development of children's behavior and morals.
PENERAPAN INOVASI KERTAS MENAMPIK (KARANGGETAS MENCEGAH KANKER SERVIKS) DI DESA KARANGGETAS KECAMATAN BANGODUA
Authors: Indra Ruswadi  , Priyanto Priyanto , Nengsih Yulianingsih
Published: October 2022

Background: As is known, cervical cancer is a cancer with the 2nd highest incidence rate in Indonesia after breast cancer. With the high cases of cervical cancer in the community, the question arises, how much is the understanding of Village Empowerment and Family Welfare (PKK) cadres in efforts to prevent cervical cancer in their area, especially teenagers about cervical cancer. Objective: To find out how the efforts of PKK cadres, especially Pokja IV TP PKK Desa in providing KIE (Communication, Information and Education) to the people of Karanggetas Village, Bangodua District in preventing cervical cancer by implementing the Kertas Menampik innovation (Karanggetas Preventing Cervical Cancer).

PKM (Community Service) is held at the Kuwu Office, Karanggetas Village, Bangodua District, Indramayu Regency from April 18-23 2022 every 10.00 WIB - 14.00 WIB for 6 (six) days. The participants came from the Pokja IV TP PKK Village management and the Posyandu Cadre of Karanggetas Village, Bangodua District, Indramayu Regency as many as 34 people. The materials needed in the meeting with Pokja IV TP PKK cadres, Karanggetas Village, Bangodua Subdistrict, namely: posters, leaflets and a description sheet of the Kertas Menampik innovation. This material was donated to TP PKK Desa, especially Pokja IV TP PKK Desa Karanggetas Subdistrict so that PKK cadres can use it in providing KIE (Communication, Information and Education) about cervical cancer prevention.

The results of the activity: PKK cadres are very happy and welcome this innovation and will disseminate information about cervical cancer prevention to the people of Karanggetas Village, Bangodua District.

Conclusion: the kertas menampik innovation has been applied to the next PKK cadres, the PKK cadres are planning to socialize this effort to the community, both during posyandu and outside posyandu activities. Suggestion: The implementation of this innovation should involve all components including: academia, business, community, government and media.
Path to Another Drug Against COVID-19
Authors: Editorial Staff
Published: October 2022

One of the crucial components in the fight against the SARS-CoV2 pandemic has been the speedy development of vaccines. However, a lack of board access, the rise of variants, and breakthrough infections are some of the many challenges that are yet to be addressed. Henceforth, it is incumbent that anaphylactic anti-viral agents against Covid be developed sooner rather than later. Although compounds acting against RNA-dependent-RNA polymerase have entered clinical trials, other viral enzymes have been identified as viable candidates for inhibition by chemical agents. Owen et al. discovered and characterized a novel drug compound that acts against the pivotal protease which catalyzes the breakage of the viral polyprotein integral in the replication of viruses.  In mouse models, the drug candidate named PF-07321332 which is administered orally has exhibited high selectivity, safety, and conferred protection against Covid infections. In vitro studies showed that the drug reached levels sufficient to inhibit the virus and this was also observed in Phase 1 clinical trials. Severe acute respiratory syndrome coronavirus 1 and Middle East respiratory syndrome coronavirus and a few other coronaviruses were also inhibited, demonstrating its potential as a possible addition to the anti-viral drug arsenal. — Science. 2021 Dec 24;374(6575):1586-1593.
Metabolite Mitigates Resistance
Authors: Editorial Staff
Published: October 2022

A growing problem that is yet to be properly addressed is the conferment of antibiotic resistance. Zhao et al. showed that in pathogenic Gram-negative bacteria, increased influx and efficacy of antibiotics was seen with the use of glutamine. The mechanism involves alteration of the metabolism of nucleotides causing the bacterial membrane to have increased non-selective permeability in bacterial strains possessing diverse resistance mechanisms. In mouse models with systemic or biofilm infections, enhanced antibiotic efficacy was seen with glutamine supplementation further strengthening its potential use. Sci Transl Med. 2021 Dec 22;13(625):eabj0716.
Boosting Adjuvant Activity
Authors: Editorial Staff
Published: October 2022

Despite a limited stock approved for clinical application, adjuvants still remain a vital component of vaccines due to their ability to enhance responses against antigens bearing poor immunogenicity. Silva and his colleagues synthesized a novel adjuvant consisting of saponin-bearing detergent-like properties and a monophosphoryl lipid A (MPLA) that serves as a Toll-like receptor 4 agonist, both encapsulated in nanoparticle structures. The novel adjuvant formulation invoked increased antibody and germinal center responses as compared to an assortment of already available adjuvants, in both mice and rhesus macaques post-inoculation of an HIV antigen that had poor immunogenic characteristics. In a mast cell-dependent fashion, increased lymphatic flow was observed with saponin–MPLA nanoparticles. Furthermore, lymph nodes also had an enhanced antigen load, indicating the mechanisms by which saponin consisting of adjuvants improves humoral immune responses. Sci Immunol. 2021 Dec 3;6(66):eabf1152.
Chimeric Co-Stimulation
Authors: Editorial Staff
Published: October 2022

It is essential that in order to prevent relapse of hematological cancers, improvements be made in chimeric antigen receptor (CAR) T-cell therapy. Katsarou et al. in an attempt to tackle conventional relapse mediators, designed chimeric costimulatory receptors, that aid CAR T-cell activation via intracellular signaling by attaching to a second tumor-associated antigen. The investigators noticed enhanced killing of tumor cells in vitro and in vivo, even against cancer cells with exceptionally low antigen density, and this was associated with improved CAR T cell persistence. Sci Transl Med. 2021 Dec 8;13(623): eabh1962.
Editor's Summaries of the Articles Published in This Issue of Molecular Medicine Communications
Authors: Editorial Staff
Published: October 2022

In this issue, Khokhar and colleagues describe their analysis of the HBV small S gene partial sequences and its implications for detection, prevention, and treatment in Pakistani patients, Chaudhary et al., reviewed studies on CYP2D6, its genetic polymorphism, and the brain, Usman and Ghaffar compiled studies on Alzheimer’s disease therapy, and discussed the effects of genetic polymorphisms on its efficacy and safety, Ximenes and her colleagues described their study to determine the certain polymorphisms in CYP2C8 gene in Pakistani population and their frequencies in various ethnic groups, Zulfiqar et al shared their study where they reported a lack of association of CYP2C9 genetic polymorphism with oral squamous cell carcinoma, and Ullah and his colleagues compiled important studies discussing venlafaxine pharmacogenetics and their implications for therapeutic efficacy and adverse effects in major depressive disease patients.
Angiotensin-Converting Enzyme Inhibitors; Their Efficacy, Adverse Effects, and the Genetic Influence on Cough They May Cause
Authors: Sheikh Arooj Fatima , Memon Fatima Siraj , Sahar Najm Ul
Published: October 2022

Hypertension is a major health condition that increases the risk of a number of other diseases, including renal failure, myocardial infarction, stroke, and death. Angiotensin-converting enzyme inhibitors (ACE-I) are part of most of the protocols being used to manage hypertension and various other conditions, including congestive heart failure, and myocardial infarction. Despite the fact that these therapies are well tolerated, one out of every five individuals discontinues them due to adverse medication reactions, the most prevalent of which is a persistent dry cough. Heritability accounts for 30% to 50% of inter-individual variation in blood pressure. However, the genetic variation connected to ACE-I-induced cough remains contentious and requires additional investigation. Genetic variation may affect the incidence of ACE-I-related cough. This article examines the efficacy of ACE-I, their adverse effects, and pharmacogenetic studies on ACE inhibitors induced cough.
Emerging Therapies in Amyotrophic Lateral Sclerosis
Authors: Fawad Laiba , Tahir Mehrab
Published: October 2022

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of cortical and spinal motor neurons, leading to weakness, muscle atrophy, and, in a substantial number of patients, cognitive impairment. Most patients die within 2 to 5 years of diagnosis. The disease initiates from the death of upper and lower motor neurons leading to a degeneration of motor pathways and the paralytic effects of the disease. The disease has huge economic costs as well. FDA has approved two drugs, riluzole, and edaravone for the treatment of ALS. However, these drugs provide modest benefits in mortality and/or function. Recent developments in the understanding of the underlying pathophysiologic processes that contribute to ALS have led to the development of numerous investigational therapies, with several now in phase 3 trials. This article highlights the epidemiology, pathophysiology, and several current and emerging treatment options for ALS including stem cell therapy.
Lessons from the Aducanumab Approval Saga
Authors: Ahmed Sagheer
Published: October 2022

One year ago, the US Food and Drug Administration (FDA) approved a drug that aims to degrade β-amyloid, a molecular target for the treatment of Alzheimer’s disease (AD). The drug, aducanumab-a monoclonal antibody, was the first drug to be approved by the FDA in the last 20 years for treating AD. The approval of this drug through an ‘accelerated approval process’ came as a shock to the scientific community working in the field of neuroscience.
It was not the ‘accelerated approval process’ itself that shocked the most, the process is in place since 1992, primarily to expedite the approval of drugs aimed at targeting life-threatening conditions for which there are no promising drugs currently available. Many were aghast at little or no demonstrated efficacy of the drug. The results of the clinical trials did not show a significant advantage to the patients. A panel of experts appointed by the FDA itself to review the trial results and make recommendations, voted almost unanimously against the approval- 10 members voting against the approval while the remaining one voted ‘uncertain’. After the FDA approval of the controversial drug, three members of the panel quit in protest.
Scientists think that this debacle had undermined the integrity of the FDA. The late-stage clinical trials were incomplete and contradictory as assessed by the FDA’s statistical reviewers and advisory committee. Despite that, the FDA granted approval to the drug makers. The next logical step, instead of approval, would have been another trial. Fixing the drug approval process is mandatory to restore the public trust in the FDA as a custodian of public health not only in the USA but throughout the global medical and pharmaceutical community.
It is time that the FDA recast itself as the custodian of public health by providing more transparency about its decision-making and ensuring drug companies produce information about the clinical benefits. This would also minimize the risk of the FDA being considered co-opted to serve commercial interests. Furthermore, the FDA should be able to easily cancel the drug approvals if the pharmaceutical companies do not provide confirmatory evidence in due time course. The US House Committee on Energy and Commerce, which oversees drug safety and biomedical research, announced in May that it hopes to grant the FDA greater authority to rescind accelerated approvals if a company fails to complete follow-up studies on the treatment in a reasonable amount of time. This is a step in the right direction and will ensure that the assessment is transparent and that companies are committed to assessing actual clinical benefits.
A New Target for Parkinson’s Disease
Authors: Editorial Staff
Published: October 2022

LRRK2 blockade has emerged as a potential target for developing disease-modifying therapies against Parkinson’s disease. Both in cellular and animal models, DNL201- a first-in-class central nervous system–penetrant LRRK2 kinase inhibitor, successfully mitigated the LRRK2 function resulting in re-establishing lysosomal activity as per the findings of Jennings and colleagues. In both healthy volunteers and patients with Parkinson’s Disease, LRRK2 kinase was inhibited by DNL201 and the drug candidate was also shown to be safe and tolerable at doses that improved lysosomal functioning. These findings argue for advanced studies on LRRK2 inhibitors including early as well as late-stage clinical investigations in patients with Parkinson's disease.  Sci. Transl. Med.14, eabj2658 (2022).
Da urbanização periférica ao direito à metrópole: a Lei 13.089/2015 no reescalonamento da política urbana
Authors: Franzoni Julia Ávila , Hoshino Thiago de Azevedo Pinheiro
Published: October 2022

A partir da vigência da Lei 13.089/2015 (Estatuto da Metrópole) e da tradição jurisprudencial do Supremo Tribunal de Justiça, à luz da qual o novo marco normativo deve ser interpretado, o presente trabalho intenta uma sistematização crítica de aspectos jurídicos ainda controvertidos sobre o planejamento e a gestão das unidades territoriais urbano-regionais. Defende-se que os instrumentos de reescalonamento da política urbana, tanto no plano da governança interfederativa quanto na coordenação e execução integrada das funções públicas de interesse comum, embora se situem num campo minado por acirradas disputas de interesses, podem prestar-se à concretização do direito à cidade, se pautados pela cidadania metropolitana (a metrópole vivida cotidianamente) e pela função social da metrópole (justiça espacial) na produção do território que extrapola as fronteiras político-administrativas fictícias dos municípios isoladamente.
O Parque Augusta e o papel dos movimentos sociais na luta pelo direito à cidade: algumas reflexões
Authors: Sotto Debora
Published: October 2022

O objetivo deste artigo foi o de promover um breve estudo de caso sobre a atuação dos movimentos sociais em prol da implantação do Parque Augusta na cidade de São Paulo, a partir da análise crítica de reportagens jornalísticas, documentos públicos e textos científicos do direito e de outras disciplinas, tomando como principal referencial teórico o conteúdo jurídico do direito à cidade. A partir dessa análise, foi possível resumir os conflitos em torno da implantação do Parque Augusta à polarização entre duas pretensões mutuamente excludentes: de um lado, a desapropriação do imóvel particular para implantação de um parque de domínio público, aberto à livre circulação e gerido pelo Poder Público com a participação da comunidade, pretendida pelos movimentos sociais com apoio da Câmara de Vereadores e do Ministério Público; e de outro lado, a construção de um empreendimento privado, composto por edifícios de uso misto e um parque privado, “aberto à fruição pública”, mas sob o domínio e gestão de particulares, pretendida pelos empreendedores imobiliários com anuência do órgão municipal de preservação do patrimônio histórico-cultural da cidade e apoio de uma das associações de moradores do entorno. Concluiu-se, ao final, que a questão central subjacente a esse conflito de interesses, responsável por motivar a atuação dos movimentos sociais em favor da implementação do Parque Augusta, reside no processo de ressignificação e reivindicação dos espaços públicos urbanos como espaços de convivência e de cidadania, iniciado pelas Jornadas de Junho de 2013, merecendo, por sua íntima relação com a dimensão política do direito à cidade, o acompanhamento cuidadoso pelos estudiosos das questões urbanas, sobretudo no âmbito do Direito Urbanístico.
Neurodevelopmental Abnormalities in Children Associated with Maternal Use of Psychoactive Medication
Authors: Tawfeek Karam T , Zuhair Ghufran Z. , Al-hussaniy Hany A. , naji Meena
Published: October 2022

Background: Due to its negative effects on the unborn child and the mother as a consumer, pregnant women's intake of psychoactive substances has become a public health concern. Additionally, consuming these chemicals has been linked to several neurological development changes in children, including behavioral issues (such as attention deficit hyperactivity disorder and autism spectrum disorder), cognitive issues, and sensory and motor function changes. Objectives: To perform a thorough, comprehensive study of the neurodevelopmental problems in children linked to maternal drug use. Method: A search of the scientific literature on studies about neurodevelopmental abnormalities linked to maternal use of psychoactive medications during pregnancy and published in the previous ten years up to June 2022 was conducted from PubMed, Google Scholar, and Directory open access Journals. Results: The initial screening identified 380 articles. We excluded 50 unaccessible articles and 160 articles due to publication dates and study types; after that, 62 articles were also discarded because they were duplicates, and 68 were excluded because the information was irrelevant or systemic reviews, so we finally obtained 40 articles for full-text reading distributed as follows: 18 from PubMed, 12 from Directory Open Access Journal, and 10 from Google scholar