bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Approaches and New Challenges of Antibiotics
Authors: Srinivas Martha , Vasantha Chintala , Singh Dr. Anoop
Published: September 2022

Antibiotics are the chemical agents that will prevent bacterial growth by stopping the bacterial cell from killing (bactericidal) or by dividing them (bacteriostatics). So, antibiotics are the essential part of medicines used for both animals and human health. In 1990s the antibiotics were first discovered to fight against microorganism. Based on their chemical structures the antibiotics are grouped into several classes. For several decades, antibiotics have been critical in fight against infectious diseases caused by bacteria and other microbes. Wound infections, tuberculosis, pneumoniae, gonorrhea, viral infections such as common cold, flu, cough are just a few of the diseases that are treated with antibiotics. The antibiotics therapy for emerging hard to treat multidrug-resistant bacterial infections is limited, resulting in high morbidity and mortality worldwide. Apparently most pathogenic microorganisms have the capability of developing resistance to atleast some antimicrobial agents. The main mechanisms of resistance are: limiting uptake of drug, modification of a drug target, inactivation of a drug and active efflux of a drug. Drug resistant infections are on the rise everywhere, and threatening public health on a major port0ion, the discovery of novel antibiotics capable of countering the counterattack by these organisms has become an emergency. Urinary tract infections, newborn infections and chemotherapy, to take just a few instances, are becoming rapidly unsafe because of the lack of working antibiotics to counter just five bacterias, including Escherichia coli (E. coli), methicillin-resistant Staphylococcus aureus (MRSA), and Klebsiella pneumoniae. Drug resistant tuberculosis is another big challenge, with over half a million cases at present, posing a high risk of infections to children. Even when novel antibiotics are developed, eventually resistance should crop up to them as well, making it significant to constantly come up with new preventive and diagnostic methods, as well as control and surveillance of contagious infections.
RP-HPLC Method Development and Validation for the Quantitative Determination of Potential Impurities of Apixaban
Authors: G. J Bharathi Tejas. , D. G Bhadre Gowda.
Published: September 2022

Quality Control is an integral part of pharmaceutical drug development. Various instrumental methodologies are developed to quantify the impurities that are developed during the stages of manufacturing, storage and transportation of pharmaceutical products. HPLC is one of the most reliable analytical methodologies to detect production and stress related impurities, to quantify them and to establish assay of active ingredient so as to pursue regulatory compliance. Here we communicate a novel method developed for impurity profiling with RP-HPLC. This study was to develop and evaluate the reverse phase high performance liquid chromatography (RP-HPLC) method for the quantitative determination of potential impurities of Apixaban active pharmaceutical ingredient. The method uses Puratis C18 column (250 × 4.6mm, 5µm) with mobile phase A consisted, 0.1% TFA in water and mobile phase B consisted acetonitrile with a gradient programme. The column temperature was maintained at 25°C and the detection was carried out at 280 nm. Results and Discussions: Efficient and reproducible chromatographic separation was achieved on C18 stationary phase in gradient elution profile. The newly developed HPLC method was validated according to ICH guidelines considering six impurities to demonstrate precision, linearity, accuracy and robustness of the method. The developed HPLC method was found to be accurate and sensitive. The correlation coefficient values are greater than 0.99 for Apixaban and its six impurities. Detection limit and quantitation limit was 0.31ppm and 0.96ppm respectively for Apixaban, indicating the high sensitivity of the newly developed method. Accuracy of the method was established based on the recovery obtained between 94.2% and 108.5% for all impurities. The result of robustness study also indicates that the method is robust and is unaffected by small variation in chromatographic conditions. The developed HPLC method provides reliable, reproducible, accurate and sensitive for the quantification of Apixaban related substances. This newly developed method has been validated as per regulatory requirements and has shown acceptable precision, accuracy and adequate sensitivity. This method can be used for the routine analysis of Apixaban active pharmaceutical ingredient related substances.
POLA STRUKTUR GEOLOGI PEMBENTUK ZONA MINERALISASI DI BUKIT RANDU, KECAMATAN SELOGIRI, KABUPATEN WONOGIRI, JAWA TENGAH
Authors: Widagdo Asmoro , Gentur Waluyo  , Rachmad Setijadi  , Mochammad Aziz  , Huzaely Latief Sunan
Published: September 2022

Mineralisasi di daerah Bukit Randu dan sekitarnya terbentuk oleh struktur geologi dengan pola yang perlu diselidiki. Penelitian ini menggunakan data gores-garis sesar, kedudukan urat kuarsa serta kedudukan uratan kuarsa. Penelitian ini bertujuan untuk mengetahui pola struktur utama pembentuk zona mineralisasi. Penelitian ini berguna untuk menentukan model struktur geologi di daerah Bukit Randu. Metode penelitian dilakukan melalui pengumpulan data di lapangan dan analisis di laboratorium. Pengumpulan data lapangan mencakup pengukuran data gores-garis, pengukuran kedudukan urat (vein) kuarsa, pegukuran uratan (veinlet) kuarsa dan pengambilan conto urat (vein) kuarsa. Analisis laboratorium meliputi analisis stereografis terhadap terhadap gores-garis dan analisis diagram bunga terhadap data pengukuran urat (vein) dan uratan (Veinlet), dan mineragrafi asahan poles urat (vein). Mineralisasi urat dan uratan kuarsa di daerah Bukit Randu dikontrol oleh sesar mendatar kanan berarah baratlaut-tenggara dan sesar normal utara-selatan. Zona mineralisasi ini merupakan zona transtensi berarah utara-selatan akibat en-enchelon right stepping sesar mendatar kanan. Mineral logam mulia hadir pada urat-urat berarah utara-selatan searah dengan arah sesar-sesar normal.
INTERCULTURAL COMMUNICATION COMPETENCE AND ACADEMIC PERFORMANCE OF INTERNATIONAL UNIVERSITY STUDENTS AT PAN AFRICAN UNIVERSITY INSTITUTE FOR BASIC SCIENCES, TECHNOLOGY AND INNOVATION
Authors: Kittot Joan , Mberia Hellen
Published: September 2022

Purpose: The objective was to determine the impact of inter-cultural communication competence on academic performance of postgraduate international students at PAUSTI, Kenya.

Methodology: The study adopted a descriptive study design. The target population was PAUSTI international students hosted at JKUAT. The study considered 240 postgraduate international student who form 80% of the total postgraduate students at PAUSTI. A questionnaire was employed in this study to gather primary data. The study used both descriptive statistics and inferential statistics. The information was analysed using statistical package for social sciences (SPSS) Version 21 computer software. Frequency, mean, standard deviation, variance, R square, t-tests, F-tests and Analysis of Variance were used to analyse the data. The study results were presented in tables and graphs

Findings: The study found out that academic performance factors relating to developed positive interpersonal relationships with others,  ppositive response to culturally different counterparts during interactions, knowing what to say when interacting with people from other cultures and asking whenever one encounter anything that she or he doesn't understand or when he or she lack the necessary cultural knowledge, a clear understanding of the complexity of elements important to members of a culture in relation to history, values, beliefs and practise were the most prevalent effects of PAUSTI international students. There is a significant relationship between inter-cultural knowledge, inter-cultural attitude, inter-cultural communication skills, inter-cultural awareness and academic performance among international postgraduate students at PAUSTI.

Unique contribution to Theory, Practice and Policy: The study therefore recommends that the findings be used to fashion policies in the institutions of higher learning to put structures in place that promotes development of inter-cultural communication competence as this affects   academic performance for international students
Predicting Whether Inflation Will Remain in the U.S. after the Covid-19 Pandemic
Authors: Lee Alex
Published: September 2022

This paper focuses on the possibility of inflation occurring in the United States in the foreseeable future. Inflation, the progressive increase in the price of goods and services over time in an economy, is affected by demand and supply. If the demand for goods and services exceeds the supply of those goods and services, prices naturally increase and rise in inflation. While many have attempted to predict inflation through various methods, no one has been able to guarantee a result as demand and supply are unstable variables. However, using the vulnerable, weak covid environment, the relationship between the CPI (Consumer Price Index) and unemployment rates was used to assemble Philips Curves.
Classical and Bayesian Estimation in Exponential Power Distribution under Type-I Progressive Hybrid Censoring with Binomial Removals
Authors: Kishan R. , Sangal P. K.
Published: September 2022

This article deals with the classical and Bayesian estimation in exponential power distribution based on Type-I progressive hybrid censoring with binomial removals at each stage. Based on the considered censoring scheme, the maximum likelihood estimates and their coverage probabilities are computed by the Monte Carlo simulation technique. MCMC technique is used to obtain the Bayes estimates under the informative priors. The performance of both the approaches is evaluated in terms of their absolute bias and mean square error (MSE) as well as the width of the confidence interval. Applicability of the suggested approach is illustrated by analysis of a real-life dataset.
Color dynamics of cooked sausages after nitrite reduction and incorporation of biologically active substances
Authors: Kolev N. D. , Vlahova-Vangelova D. B. , Balev D. K. , Dragoev S. G.
Published: September 2022

In most cases, the color of meat products is the factor influencing consumer choice. It’s formation and preservation is the highest priority. Sodium nitrite is used for fixation of the pleasant pink-red color, but also has a negative image from the consumers oriented towards clean label products. The valorization of rose oil-industry by-products by their incorporation in foods as natural additives is growing research area. The formulated cooked sausage recipes, contain blend of three biologically active substances (BAS) and different level of sodium nitrite reductions: AN100, AN75, AN50, AN25, AN0 and control - C. Color attributes CIE L*, a*, b* were assessed during 14 days of chilled storage (0-4 °C) and their changes in dynamics were evaluated every 10 min for an hour at air exposure. The incorporation of the inhibit the oxidation of meat pigments during the chilled storage and slowed down the fading of the pinkred color of the cross-cut surface during the 60 min of air exposure. The sausages produced with up to 50 % nitrite reduction and the blend of three BAS have lower lightness (L*), higher intensity of the red color (a*) and lower yellowness (b*) of the cross-cut surface in comparison to the control.
Mathematical description of the processes occurring during active grain ventilation
Authors: Ostrikov А. N. , Nurakhmetov B. K. , Askarov A. D. , Medvedkov E. B.
Published: September 2022

The subject of the study is the process of active ventilation of wheat grain with variable heat supply.

   The purpose of the work is a mathematical description of the nature of the flows of matter and energy in the process of active ventilation of wheat grain.

   Thanks to the selected original design of the exhaust coolant outlet unit, made in the form of a mesh spiral tube, it was possible to optimize the hydrodynamic situation in the layer of dried grain. The developed mathematical model, as a mathematical description, consists of equations of material, thermal balances, equations of hydrodynamics in steady and unsteady states. This mathematical model is the basis for creating a material model of the process and conducting an experiment with subsequent data processing. As a result, it is possible to obtain criteria equations of processes that make it relatively easy to calculate processes under various technological modes.
Development and study of the ski package of clothes with improved operation properties
Authors: Agibayeva A. E. , Mokeeva N. S. , Zhilisbayeva P. O. , Ermanova G. K.
Published: September 2022

The article is devoted to methods of determination of physical - mechanical properties of membrane materials, nonwoven insulators and clothing package in general. The standard known methods and methods of research are described, as well as the influence of operational and production factors on the structure and properties of membrane tissues that form packs of clothing materials. The physical and mechanical properties of membrane tissues to abrasion in the plane have been investigated, tensile to fracture, elongation, indestructibility, vapour permeability, water resistance, thermal conductivity, breathability. The article presents a reasonable selection and characterization of research objects, materials that form packs of heat-resistant clothing: top tissues - membrane fabrics, insulation - nonwoven volumetric insulation, lining and auxiliary materials and developed packages of heat-proof clothing.
Development of a method for fire-resistant finishing of non-woven material using a phosphorus-containing composition
Authors: Sarymsakova A. T. , Burkitbay A. , Tausarova B. R.
Published: September 2022

The aim of the study is to obtain a non-woven material with flame retardant properties.

   The conditions of the process of fire-retardant finishing were as follows: an aqueous solution of preparations of various concentrations was applied by spraying onto the surface of the material, then drying was carried out and heat treatment on a thermal press. According to GOST R 50810-95, non-woven material made from flax and wool fibers, treated with a composition based on an aqueous solution of sodium phosphate and guanidine hydrochloride, is classified as a flame-retardant material. Also, tests for toxic and skin-irritating effects of non-woven material treated with the proposed composition showed its safety for human health.
Estágio de docência na formação inicial em Educação Física na educação infantil: reflexões sobre a prática pedagógica durante a pandemia da COVID-19
Authors: Dahlke Ana Paula , Ricardo Karoline Hacler , Silva Lisandra Oliveira e
Published: September 2022

A partir de escritas realizadas no Diário de Campo, documento onde registramos detalhes da prática pedagógica, e guiadas pelo questionamento: “que oportunidades de conhecimento as aulas de Educação Física têm oferecido aos estudantes na Educação Básica?”; este artigo objetiva compartilhar a experiência do Estágio de Docência de Educação Física na Educação Infantil, componente curricular obrigatório na formação do Curso de Licenciatura em Educação Física da Universidade Federal do Rio Grande do Sul. Esta experiência ocorreu entre janeiro e maio de 2021, no modelo de Ensino Remoto Emergencial, em meio a pandemia da COVID-19, desenvolvida para duas turmas de Maternal 1, de uma escola pública de Educação Infantil de Porto Alegre/RS. Apesar dos desafios enfrentados, percebemos que aprendemos mais do que ensinamos, e que a pergunta em evidência está em processo de compreensão, a partir do que se faz ao longo da Formação Inicial e da prática pedagógica em escolas reais.
ALTERAÇÕES HEMATOLÓGICAS EM GESTANTES COM COVID-19
Authors: Diógenes Peixoto de Medeiros Pedro , De Holanda Cabral Vinicia , Oliveira de Jesus Laiany , Diógenes Peixoto de Medeiros Sara , Paschoalette Rodrigues Bachur Tatiana
Published: September 2022

Introdução: Este estudo objetivou descrever as alterações hematológicas presentes em gestantes com COVID-19 descritas na literatura. Métodos: Foram realizadas buscas nas bases de dados SCOPUS, MEDLINE, LILACS e EMBASE.  Foram selecionados quinze artigos, que atenderam aos critérios de inclusão. A amostra foi composta por uma maioria de relatos de casos (53,3%) e apenas um estudo prospectivo (6%). Resultados: Entre as alterações evidenciadas nos estudos, destacou-se a elevação do D-dímero, trombocitopenia, PCR elevada, além de hiperfibrinogenemia ou hipofibrinogenemia. Verificou-se, ainda, aumento importante nos níveis de TTPA nas mulheres infectadas. Em alguns estudos, não foram notadas alterações significativas entre gestantes com e sem a doença, observando-se, em especial, gestantes com quadros leves ou moderados da infecção. As complicações relacionadas às alterações hematológicas descritas foram o tromboembolismo pulmonar, trombose da artéria esplênica e sangramento intraoperatório anormal. Destacou-se a possibilidade de ajuste na anticoagulação profilática, além da necessidade de vigilância rigorosa a essas mulheres.Conclusão: Por fim, ressaltou-se a importância da realização de outros estudos mais aprofundados, que permitam estudar melhor a associação dessas alterações com a infecção pelo SARS-CoV-2.
Improving the effectiveness of non-governmental organizations
Authors: Kenzhetayeva Аssel , Aliyeva Anel
Published: September 2022

The tasks facing Kazakhstan today require enhanced interaction between the state and non-governmental organizations, a systemic reset of civil society institutions. It is necessary to involve public organizations and activists more widely and deeply in the preparation and implementation of reforms. To do this, first of all, it is necessary to ensure open discussions of all national projects and strategic documents. In this matter, any imitation, creating the appearance of a dialogue is unacceptable. We must awaken civic activity in the country and launch a process of conscious and constructive partnership between the state and society. It is for this reason that we are developing public councils under central and local executive state bodies, as well as in the quasi-public sector [1]. Non-governmental organizations play a key role in the formation and implementation of participatory democratic structures. Their authority is explained by the responsible and constructive role they play in society. Official and unofficial organizations, as well as grassroots movements should be recognized. The nature of the independent role that non-governmental organizations play in society dictates the need for real participation; therefore, independence is one of the basic and integral properties of non-governmental organizations and an indispensable condition for real participation. Today, when the world community is striving to move away from irrational development models and embark on the path of environmentally safe and sustainable development, one of the main tasks facing it is to promote understanding of a common goal in all segments of society. The ability to ensure an understanding of such a goal will depend on the willingness of all segments of society to participate in truly broad cooperation and dialogue and on the recognition of the independent role, obligations and special potential of each.
Проблематика роману Юсуфа Болата «Алім Син Азамата»: релігія, гендер, міграція
Authors: Дворова Ольга
Published: September 2022

Досліджено роман Юсуфа Болата «Алім син Азамата». Окреслено основні проблеми, що були порушені у творі. Детально охарактеризовано основні образи роману: образ Аліма, Ресуля ефенді, Меміша аги. Уривки з твору наводяться в оригіналі та перекладах.
Модель універсального командного пункту в інформаційно-розрахунковій системі «Аргумент–2022»
Authors: Савельєв Андрій , Запара Денис , Новіченко Сергій , Коломійцев Олексій , Деменко Микола , Третяк Вячеслав , Кривчун Валерій , Довгалюк Денис , Пустоваров Володимир , Любченко Олексій
Published: September 2022

Інформаційно-розрахункова система «Аргумент–2022» призначена для підтримки прийняття рішення командиром частини ЗРВ при виборі бойового порядку частин та підрозділів ЗРВ і оцінки ефективності бойових дій угруповання ЗРВ яке створено. Модель універсального КП представляє собою сукупність параметрів та алгоритмів обчислення. Слід зазначити, що інформаційно-розрахункова система «АРГУМЕНТ 2022» використовується в штабах Повітряних Сил, штабі зенітної ракетної бригади (полку), командному пункти зенітного ракетного дивізіону для підтримки прийняття рішення на бойові дії, а також є інтерактивною і часових обмежень на її роботу не існує.
Exploration on Curriculum System Construction of Ideological and Political Education Integrating into College Students' Career Planning
Authors:   Asia Social Science Academy, Yu Jia
Published: September 2022

The initial intention of education is to cultivate people with virtue, and career planning in colleges and universities is the most important basic course for college students. Under the background of ideological and political education, it is an important task for colleges and universities to build a career planning curriculum system. The purpose of this paper is to construct the curriculum system of career planning from the aspects of curriculum objectives, curriculum contents, teaching staff construction and curriculum evaluation under the guidance of ideological and political spirit.
”Yhteinen henkinen tila”
Authors: Walden-Antikainen Susanna
Published: September 2022

The fame of the Finnish composer Yrjö Kilpinen (1892–1959) in Nazi Germany was evident in newspapers and classical music magazines. In this article, I examine how Nazi propaganda was constructed in German newspaper articles related to Yrjö Kilpinen from 1934 to 1944.

Since the end of World War II, questions have lingered regarding Kilpinen’s associations with the Third Reich. As a member of Nazi cultural organisations such as Ständiger Rat für internationale Zusammenarbeit der Komponisten and as a friend of baritone Gerhard Hüsch, Reich Chamber of Music’s vice president Paul Graener and Ständiger Rat delegate Emil von Reznicek, Kilpinen made a career in Germany that was at its peak from 1934 until 1944. This article examines how Kilpinen’s fame was viewed in the press.

I suggest that the Nazi newspaper articles did not highlight Kilpinen’s status as an independent artist but instead focused on building a common national identity between Finland and Germany, based on National Socialist journalists’ and Kilpinen’s perceptions of Finnishness and national socialist ideology. This study is based on the discourse-historical approach, which maintains that national identity is formed in discourses of identification, solidarity and differentiation. The central aim of the study is to identify the discursive strategies whereby the connection between Finland and Germany was built.

The research material consists of eleven Nazi Germany newspaper and magazine articles about Yrjö Kilpinen. In the analysis, two discourses emerge that emphasize similarity between Finland and Germany: 1) Nordisch and 2) Volk and völkisch. With these discourses, the press aimed to build a common national identity by linking National Socialist ideology to Finland and Yrjö Kilpinen.
Enzio Forsblom tutkimuksen kohteena
Authors: Ranta-Meyer Tuire
Published: September 2022

Sibelius-Akatemian kirkkomusiikin ja urkujen aineryhmä järjesti Enzio Forsblomin, Suomen urkutaiteen yhden voimahahmon syntymän 100-vuotisjuhlasymposiumin vuonna 2020. Esitelmistä on koottu Peter Peitsalon toimittama julkaisu, jossa tarkastellaan kohdehenkilön merkittävää roolia J. S. Bachin urkumusiikin esityskäytäntöjen tutkijana, levyttävänä urkutaiteilijana, yhdistysten aktiivijäsenenä ja puheenjohtajana sekä urkujen suunnittelijana. Oman mausteensa artikkelikokoelmaan tuovat tekstit, joissa jäsennetään Forsblomin toimintaa kaunokirjallisuuden ja julkisten radioesitelmien parissa. Tärkeän aspektin ja jatkokeskustelun aiheen julkaisussa avaa artikkeli, jossa pohditaan Forsblomia ideologina, poliitikkona ja vallankäyttäjänä.
Marital Satisfaction and Depression in Older Adults: A Literature Review
Authors: Karakose Selin
Published: September 2022

Marital satisfaction is an important concept contributing to depression. In contrast to younger and middle-aged individuals, the negative association between marital satisfaction and depression has been reported to be strongest among older adults. This study reviewed the association between marital satisfaction and depression in older adults. Based on the literature review, findings demonstrated that older women have lower marital satisfaction and higher depression level compared to older men. Also, although spouse support is a primary source of social support and an influential protective factor against depression in older marriages, older women have less spouse support than older men. According to the findings, older women are at increased risk for depression due to poorer marital satisfaction and spousal support.
Image muting of mixed precipitation to improve identification of regions of heavy snow in radar data
Authors: Tomkins Laura M. , Yuter Sandra E. , Miller Matthew A. , Allen Luke R.
Published: September 2022

Abstract. In winter storms, enhanced radar reflectivity is often associated with heavy snow. However, some higher reflectivities are the result of mixed precipitation including melting snow. The correlation coefficient (a dual-polarization radar variable) can identify regions of mixed precipitation, but this information is usually presented separately from reflectivity. Especially under time pressure, radar data users can mistake regions of mixed precipitation for heavy snow because of the high cognitive load associated with comparing data in two fields while simultaneously attempting to discount a portion of the high reflectivity values. We developed an image muting method for regional radar maps that visually de-emphasizes the high reflectivity values associated with mixed precipitation. These image muted depictions of winter storm precipitation structures are useful for analyzing regions of heavy snow and monitoring real-time weather conditions.
Multi-scenario multi-objective analysis of downscaled shared socio-economic pathways (SSPs) for robust policy development in coupled human-water systems
Authors: Alizadeh Mohammad Reza , Adamowski Jan , Qadir Manzoor
Published: September 2022

Abstract. Shared socio-economic pathways (SSP) scenario analysis is concerned with developing climate change adaptation strategies that perform well across a wide range of plausible future socio-economic and climate change conditions. However, downscaled/localized SSP scenarios, most relevant for regional climate adaptation, are poorly understood in terms of their deep uncertainties and how these scenarios can contribute to the development of robust regional policies in coupled human-water systems. In the present study, we propose a new framework that integrates a multi-scenario multi-objective (meta-criteria) optimization analysis of a set of downscaled/localized SSP storylines with the robust decision-making concept to find optimal robust solutions under deep uncertainty concerning regional climate adaptation. By developing an integrated dynamic simulation-optimization model, potential policy alternatives are investigated, and their robustness evaluated based on four key objectives: farm income, groundwater depletion, soil salinity, and reliability. Scenario-based multi-objective optimization for multiple SSP scenarios is merged into a robust optimization problem and evaluated in parallel. The proposed framework is applied to study potential robust solutions for vulnerabilities of a real-world human-water system in Pakistan's Rechna Doab region that has multiple stakeholders and conflicting objectives. The results revealed Pareto optimal solutions that are both optimally feasible and robustly efficient. The socio-environmental conditions of SSPs have a significant influence on the estimated robustness. The candidate solutions under scenario SSP1 are remarkably comparable to those offered by scenario SSP5, which was deemed to be the best among the SSPs evaluated. SSP3 was the least desirable of the SSP scenarios examined and solutions resulted in undesirable soil salinity, groundwater depletion, and reliability values. By incorporating SSP narratives and quantitative scenario analysis, the proposed framework revealed advantages for integrated dynamic modelling of human-water systems with a high level of uncertainty and complex interconnections to discover robust climate change adaptation solutions.
Present and future thermal regimes of intertidal groundwater springs in a threatened coastal ecosystem
Authors: KarisAllen Jason J. , Mohammed Aaron A. , Tamborski Joseph J. , Jamieson Rob C. , Danielescu Serban , Kurylyk Barret L.
Published: September 2022

Abstract. In inland settings, groundwater discharge thermally modulates receiving
surface water bodies and provides localized thermal refuges; however, the
thermal influence of intertidal springs on coastal waters and their thermal
sensitivity to climate change are not well studied. We addressed this
knowledge gap with a field- and model-based study of a threatened coastal
lagoon ecosystem in southeastern Canada. We paired analyses of drone-based
thermal imagery with in situ thermal and hydrologic monitoring to estimate
discharge to the lagoon from intertidal springs and groundwater-dominated
streams in summer 2020. Results, which were generally supported by
independent radon-based groundwater discharge estimates, revealed that
combined summertime spring inflows (0.047 m3 s−1) were comparable
to combined stream inflows (0.050 m3 s−1). Net advection values for the
streams and springs were also comparable to each other but were 2 orders
of magnitude less than the downwelling shortwave radiation across the
lagoon. Although lagoon-scale thermal effects of groundwater inflows were
small compared to atmospheric forcing, spring discharge dominated heat
transfer at a local scale, creating pronounced cold-water plumes along the
shoreline. A numerical model was used to interpret measured groundwater temperature
data and investigate seasonal and multi-decadal groundwater temperature
patterns. Modelled seasonal temperatures were used to relate measured spring
temperatures to their respective aquifer source depths, while multi-decadal
simulations forced by historic and projected climate data were used to
assess long-term groundwater warming. Based on the 2020–2100 climate
scenarios (for which 5-year-averaged air temperature increased up to
4.32∘), modelled 5-year-averaged subsurface temperatures increased
0.08–2.23∘ in shallow groundwater (4.2 m depth) and
0.32–1.42∘ in the deeper portion of the aquifer (13.9 m),
indicating the depth dependency of warming. This study presents the first
analysis of the thermal sensitivity of groundwater-dependent coastal
ecosystems to climate change and indicates that coastal ecosystem management
should consider potential impacts of groundwater warming.
Leveraging sap flow data in a catchment-scale hybrid model to improve soil moisture and transpiration estimates
Authors: Loritz Ralf , Bassiouni Maoya , Hildebrandt Anke , Hassler Sibylle K. , Zehe Erwin
Published: September 2022

Abstract. Sap flow encodes information about how plants regulate the opening and closing of stomata in response to varying soil water supply and atmospheric water demand. This study leverages this valuable information with model–data integration and deep learning to estimate canopy conductance in a hybrid catchment-scale model for more accurate hydrological simulations. Using data from three consecutive growing seasons, we first highlight that integrating canopy conductance inferred from sap flow data in a hydrological model leads to more realistic soil moisture estimates than using the conventional Jarvis–Stewart equation, particularly during drought conditions. The applicability of this first approach is, however, limited to the period where sap flow data are available. To overcome this limitation, we subsequently train a recurrent neural network (RNN) to predict catchment-averaged sap velocities based on standard hourly meteorological data. These simulated velocities are then used to estimate canopy conductance, allowing simulations for periods without sap flow data. We show that the hybrid model, which uses the canopy conductance from the machine learning (ML) approach, matches soil moisture and transpiration equally as well as model runs using observed sap flow data and has good potential for extrapolation beyond the study site. We conclude that such hybrid approaches open promising avenues for parametrizations of complex water–plant dynamics by improving our ability to incorporate novel or untypical data sets into hydrological models.
The pensions White Paper: taking account of gender
Authors: Price Debora
Published: September 2022

Many women face severe obstacles in accumulating adequate income in later life. The pensions White Paper heralds substantive reform of the pension system, with certain elements assisting women in future to build pension entitlements. The extent to which the reforms will have the desired effect is, however, unclear since the system remains complex and means-tested benefits will remain a substantial element of pensioner income for many in the population. The government has committed to a gender impact assessment of the reforms. This article explores the elements of the pension system that should be evaluated if this assessment is to take full account of gender.
Assessing the policy trajectory of welfare reform in Australia
Authors: Marston Greg , McDonald Catherine
Published: September 2022

Although its roots reach back into the 1980s, the Australian version of welfare reform has intensified over the last decade under the direction of the conservative Howard government. In this article we chart the path to welfare-to-work policies, noting both the discontinuities as well as a degree of continuity with Australia’s traditional approach to social protection. As such, welfare reform in Australia is both revolutionary and evolutionary. Further, its acceptance by the Australian public has been shaped by a sophisticated form of persuasion couched within a discourse of ‘participation’ and ‘obligation’. Finally, we note that in the case of welfare reform, Australia’s approach has switched its traditional reliance on UK social policy models to a social security system designed on the principles of welfare reform as implemented in the US.
Penerangan jalan umum untuk desa margalaksana kecamatan cikakak kabupaten sukabumi
Authors: Fahmi Al Gadri Feri , Rido Taufik , Febriani Indri , Asian Jelita , Mupaat
Published: September 2022

Penerangan jalan umum adalah suatu fasilitas yg dibutuhkan oleh masyarakat terlebih lagi pada malam hari dimana dengan adanya suatu penerangan jalan ini masyarakat akan merasa lebih nyaman dan aman saat akan melakukan aktivitas dimalam hari.adapun penelitian ini dilakukan yaitu dengan tujuan untuk mengkaji suatu perencanaan pemasangan lampu jalan di desa Margalaksana kecamatan cikakak mengingat di desa Margalaksana ini masih banyak daerah-daerah tertentu yg kurang pencahayaan padahal di desa ini seharusnya tidak minim pencahayaan karena daerah ini terletak di pedalaman banyak dikelilingi kebun dan hutan sehingga tidak menutup kemungkinan tingkat kejahatan masih tinggi dan hewan liar pun bisa memasuki desa ini dan membahayakan masyarakat. Dengan mempertimbangkan faktor keselamatan pengguna jalan dan keamanan lingkungan sekitar maka perlu direncanakan penerangan jalan umum dengan memanfaatkan energi dari sumber terbarukan yaitu energi surya. Berdasarkan hasil penelitian yang telah dilakukan di sepanjang jalan desa Margalaksana kec. cikakak membutuhkan lampu dan tiang masing-masing sebanyak 3 buah.
TINGKAT KECEMASAN PADA IBU HAMIL TRIMESTER III MULTIGRAVIDA PADA MASA PANDEMI COVID-19 DI DESA SUMURGUNG KECAMATAN TUBAN
Authors: Apriliana Wulan , Retna P Teresia , Wahyurianto Yasin
Published: September 2022

Ibu hamil rentan merasakan kawatir tentang hal yang dapat terjadi pada dirinya dan anaknya yang beresiko mengganggu kesehatan mental ibu, salah satunya gangguan kecemasan. Di masa pandemi virus corona ibu hamil akan cemas apalagi pada ibu hamil trimester III yang akan melahirkan. Data survey awal didapatkan 90% ibu hamil multigravida merasakan cemasa  dan  10% ibu hamil multigravida tidak merasa cemas dari jumlah total 10 ibu hamil. Tujuan penelitian ini untuk mengetahui tingkat kecemasan pada ibu hamil trimester III multigravida pada masa pandemi covid-19 di Desa Sumurgung. Desain penelitian deskriptif dan pendekatan yang dipakai yaitu “cross-sectional”, populasinya yaitu ibu hamil trimester III multigravida yang tinggal  di Desa Sumurgung kecamatan Tuban sebanyak 113 ibu, besar sampel 88 ibu hamil, teknik yang dipakai yaitu  simple random sampling. Instrumen yang dipakai adalah kuesioner. Hasil dari penelitian didapatkan hampir seluruhnya tingkat kecemasan ibu hamil trimester III multigravida di Desa Sumurgung mengalami kecemasan berat sejumlah 72 orang ( 82%). Tingkat kecemasan pada ibu hamil trimester III multigravida di masa pandemi virus corona dengan karakteristik ibu diantaranya tingkat pengetahuan,  tingkat pendidikan ,serta dukungan dari keluarga terutama suami di Desa Sumurgung masih dalam kategori cemas berat. Maka dari itu perlu melakukan pengoptimalan dalam peningkatan pengetahuan dan pemberian dukungan secara terus menerus agar dapat menurunkan tingginya tingkat kecemasan ibu hamil trimester III multigravida.Kata kunci :          Tingkat Kecemasan, Ibu Hamil Trimester III multigravida, Pandemi Covid-19
ANALISIS ASUHAN KEPERAWATAN DENGAN INTERVENSI INOVASI TERAPI REMINISCENCE PADA LANSIA DEPRESI
Authors: Tobing Duma Lumban
Published: September 2022

Depresi merupakan gangguan mental, berawal dari stres yang tidak bisa diatasi, maka seseorang bisa jatuh di fase depresi. Depresi terjadi pada lansia disebabkan oleh adanya perubahan menua dan masalah yang kemudian ditimbulkan sebagai akibat dari perubahan tersebut. Terapi reminiscence atau terapi kenangan merupakan salah satu bentuk psikoterapi yang dapat membantu menurunkan depresi. Tujuan penelitian ini adalah untuk memberikan gambaran analisis asuhan keperawatan dengan intervensi inovasi terapi reminiscence pada lansia dengan masalah depresi di PSTW Budi Mulia I Cipayung Jakarta. Terapi diberikan sebanyak 6 sesi selama 45-60 menit. Penelitian berdesain quasi eksperimental pre dan post test. Sejumlah 5 lansia direkrut menjadi responden. Pengkajian depresi menggunakan instrumen Geriatric Depression Scale - Short Form (GDS-SF). Analisis bivariat yang digunakan dalam penelitian ini adalah uji T Dependen dengan p-value<0,05. Hasil penelitian ini didapatkan adanya pengaruh pemberian terapi reminiscence terhadap tingkat depresi lansia (p-value = 0,001). Tingkat depresi dapat diturunkan dengan melakukan intervensi yang tepat. Oleh sebab itu diharapkan perawat dapat membantu memaksimalkan pelayanan kesehatan di panti khususnya dengan melakukan intervensi psikoterapi seperti terapi reminiscence.
White Matter Integrity in Men With Benign Prostatic Hyperplasia and Bladder Outlet Obstruction and Its Contribution to Lower Urinary Tract Symptoms
Authors: Jang Yongchang , Tran Khue , Hubbard Logan , Choksi Darshil , Gonzalez Ricardo R. , Karmonik Christof , Shi Zhaoyue , Khavari Rose
Published: September 2022

Purpose: Lower urinary tract symptoms (LUTS) associated with bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) can negatively impact quality of life. We evaluated the structural connectivity of the brain in men with BPH with chronic BOO using diffusion tensor imaging (DTI).Methods: Ambulatory male patients aged ≥45 years with BPH and BOO were recruited. LUTS was defined as an International Prostate Symptom Score (IPSS) ≥12 and a maximum urinary flow rate ≤15 mL/sec. Upon recruitment, uroflowmetry and validated questionnaires regarding bladder status were collected. DTI images from each subject were aligned with the ICBM-DTI-81 atlas, defining 50 white matter tracts (WMTs). The mean values of DTI parameters—fractional anisotropy and mean diffusivity—for each WMT were extracted. These measures were then utilized to compute Pearson correlation coefficients with clinical parameters. Objective clinical parameters included uroflowmetry parameters, postvoid residual (PVR) volume, and bladder capacity. Subjective clinical parameters were assessed using validated questionnaires: the IPSS, Incontinence Symptom Index, and Sexual Health Inventory for Men.Results: The correlation analysis revealed 15 WMTs that showed statistically significant associations (P<0.05) with objective and subjective clinical parameters. Eight tracts were associated with uroflowmetry parameters: maximum flow rate (Qmax), mean flow rate (Qmean), and PVR. Among these tracts, the middle cerebellar peduncles and left medial lemniscus were associated with Qmax; the genu of the corpus callosum, left superior corona radiata, corticospinal tract, right medial lemniscus, posterior corona radiata with Qmean; and the left posterior corona radiata with PVR. Seven tracts also demonstrated significant associations with the IPSS.Conclusions: Our results suggest correlations between the preserved white matter integrity of specific WMTs and the severity of LUTS based on objective and subjective clinical parameters, leading us to believe that a distinct pathology of the central nervous system might exist.
Functional and Immunofluorescence Evaluations of Vascular and Neural Integrities in Urinary Bladder of Streptozotocin-Induced Diabetic Mice
Authors: Kwon Mi-Hye , Choi Min-Ji , Liu Fang-Yuan , Fridayana Fitri Rahma , Niloofar Lashkari , Yin Guo Nan , Ryu Ji-Kan
Published: September 2022

Purpose: To assess functional and structural changes in vascular and neural structures associated with diabetic bladder dysfunction (DBD) in the bladders of streptozotocin (STZ)-induced diabetic mice.Methods: Eight-week-old C57BL/6 mice were injected with STZ at 50 mg/kg daily for 5 consecutive days. Catheters were inserted 12 weeks later, and 5 days after catheter placement bladder functions were assessed by conscious cystometry. Neurovascular and extracellular matrix marker changes in harvested urinary bladders were investigated by immunofluorescent staining. Body weights and fasting and postprandial blood glucose levels were measured 12 weeks after STZ injection.Results: STZ-induced diabetic mice had significantly lower body weights and significantly higher blood glucose levels. Assessment of bladder function in STZ-induced diabetic mice revealed a nearly 3-fold increase in bladder capacity and intercontractile interval compared to controls. However, basal pressure, maximal bladder pressure, and threshold pressure were not significantly different. Morphological and structural analysis showed that STZ-induced diabetic mice had significantly reduced microvascular density in lamina propria (33% of the nondiabetic control values), and severely decreased nerve contents in the detrusor region (42% of the nondiabetic control values).Conclusions: STZ-induced diabetic mice exhibit functional and structural derangements in urinary bladder. The present study provides a foundation and describes a useful means of evaluating the efficacies of therapeutic targets and exploring the detailed mechanism of DBD.
Investigation of Epstein-Barr Virus antibodies by ELISA and IFA Methods
Authors: EKŞİ Fahriye , KARSLIGİL Tekin , ERİNMEZ Mehmet , PEHLİVAN Mustafa
Published: September 2022

Epstein-Barr Virus (EBV), play role in etiology of malignancies as Burkitt Lymphoma and Nasopharyngeal Carcinoma alongside very common situation like Infectious Mononucleosis. Also in patients groups, like transplant and oncologic patients whose immune system especially depressed detection of EBV reactivation is important. In this study, investigation of results defined by Immunofluorescent Antibody (IFA) and Enzyme-Linked ImmunoSorbent Assay (ELISA) methods aimed. Between 2017 July and 2020 July in our laboratory, With 7455 samples Anti-VCA IgM results detected by the ELISA method were 3.9% positive, 94.1% negative, and 3% borderline. With 5510 samples Anti-VCA IgG results detected by the ELISA method were 82,3% positive, 16.1% negative, and 1.6% borderline. With 449 samples, 32.9% of Anti-VCA IgM, 96.8% of Anti-VCA IgG,55% of Anti-EA IgG, and 93.5% of Anti-EBNA antibody results detected by the IFA method were positive. Positive Anti-VCA IgM results were 3% by ELISA and 25% by the IFA, positive Anti-VCA IgG results were 96.3% by ELISA and 98% by IFA. ELISA Anti-VCA IgG sensitivity was found to be 96.3% and ELISA Anti-VCA IgM sensitivity was found to be 12.9% in statistical analysis, considering IFA as the gold standard. For serological diagnosis of acute EBV infection or reactivation of latent infection EBV Anti-VCA IgM, Anti-VCA IgG, Anti-EBNA IgG, Anti-EA IgG, and Anti-VCA IgG avidity antibodies should be evaluated together.
Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic
Authors: AKDOĞAN Özlem , YAPAR Derya , ÇEBİ Kazım , ARSLAN Sertaç , BOYACI Hilal , ARI YILMAZ Yasemin , TUNÇEL ÖZTÜRK Pınar , SAVCI Ünsal , KAYADİBİ Hüseyin , YILMAZ Ayşe , GÜLHAN Meral , KOCAGÜL ÇELİKBAŞ Aysel , BAYKAM Nurcan
Published: September 2022

Early diagnosis in COVID-19 is essential in terms of treatment and prevention of contagiousness. In this study, we aimed to find an alternative diagnosis method by using fewer laboratory parameters in the early diagnosis of COVID-19 disease by creating a fast, easily accessible, cost-effective index and has a diagnostic accuracy rate of over 90%. All patients over the age of 18 who applied to Hitit University Erol Olçok Training and Research Hospital Emergency COVID Outpatient Clinic with a pre-diagnosis of COVID-19 between March and April 2020 were evaluated retrospectively. Patients were divided into two groups as COVID-19 positive and COVID-19 negative. It was aimed to create a HITIT-19 index by evaluating the cases according to the clinical and laboratory results. Between March and April 2020 (in the first peak of the pandemic), 1586 patients were applied to the Emergency COVID-19 outpatient clinic with a pre-diagnosis of COVID-19. According to COVID-19 RT-PCR, card test, and CT involvement, 285 (13%) patients were diagnosed with COVID-19. PCR was positive in 285 (18%) of 1586 patients, and PCR was negative in 1301 (82%). While 153 (53.7%) of the patients diagnosed with COVID-19 were male and the median age was 45 (28-62.75), 883 (55.7%) of the patients not diagnosed with COVID-19 were male, and the median age was 43 (31-65). Hypertension (HT) was the most common underlying disease in 10.5% of patients applied to the emergency room with a diagnosis of COVID-19, while 38.9% dyspnea and 35.1% fever were the most common symptoms. While 76% of Plaquenil and 58% azithromycin were the most frequently started treatments, 31.4% (28.4% of them were hospitalized in the service, 3% in the intensive care unit) of them hospitalized. It was to create a HITIT-19 index that is fast, easily accessible, cost-effective, and has a diagnostic accuracy rate of over 90% by using laboratory tests. However, we could not achieve this goal due to the low accuracy of the diagnostic tests and the lack of significant change in the laboratory levels of the patients at admission. Considering that the pandemic is continuing rapidly, there is still a need to develop practical diagnostic methods that are easier and cheaper in diagnosis. In this sense, we believe that our study will be a guiding study for other studies that will be designed for diagnostic index studies.