bluuebunny/crossref_metadata_2025 huggingface dataset:
PENELUSURAN KAWASAN ALUN-ALUN BUNDER KOTA MALANG SEBAGAI OPEN SPACE RANCANGAN IR KARSTEN
Authors: Putra R. Dimas Widya
Published: June 2020

Title: Searching of Alun-Alun Bunder District in Malang City as Open Space which was Built by Ir Karsten

Alun-Alun Bunder plays an important role for city of Malang development during Dutch collonialism. Alun-Alun Bunder was the policy for expanding the second city (Bouwplan II) which had the total size of 15.547 M2. the reason of Alun–Alun Bunder designing was to establish the new administration pivot, this main reason became the basis for the governance at that time (Gemeente) to design the second city expansion (Bouwplan II). This district was named as Gouverneur-Generaalbuurt. The design was realized in 1922. In subsequent, this area was known as „Alun-Alun Bunder”. The research purpose are to know the development pattern of Alun-Alun Bunder, identification of landscape function as the landmark which use as interaction space. Analysis technique which is used in this research, consist of ; diachronic reading, descriptive- evaluation related by linkage pattern and synchronic reading. The result shown that Alun-Alun Bunder is the best city hall model which was desired by Dutch government. The infrastructure, among them are; settlement, education and transportation are designed to follow the role of Alun- Alun Bunder as the core of Dutch administration. The strategy to strengthen the historical value in Alun-Alun Bunder is gained by strengthening the linkage towards historic object which exist inside.
PEMBERDAYAAN LOKALITAS DAN KREATIVITAS: UPAYA MENUJU BANDUNG KOTA KREATIF
Authors: Rahayu Tri , Sugiarto Roni
Published: June 2020

Title: Empowerment of Locality and Creativity: The Effect towards Bandung Creative City

As modernity with all rigidity and practically increasingly creeping, the locality was still elegant with its charm. Localities seems to be a special allure which become healer of longing of the past. Everything related to tradition inspires architects and city planners. Creative design certainly has allure for residents, local and non local tourists. Bandung is the city wellknown as Paris Van Java, which has consequence to the arrangement of the infrastucture and face of the city with strong identity of exquisite Sundanese culture. These opportunities would require creativity which offer uniqueness and special identity of Bandung. The study of city arrangement, planning stategy towards creative city, and sustainable strategy would be essential to realize the Bandung Creative City. The study was conducted by observing Bandung infrastucture at some central points in the heritage building until face of the city, and how the goverment‘s strategy to overcome this problem, related to creativity. The result shows that efforts to Bandung Creative City is done through empowerment of ?creative economy‘ in fashion, culinary, and design decorate city faces up to hilly region. Creative city allows the achivement of community prosperity and economically independence. Furthermore, through ?Bandung Creative City‘ program, the impact is not only to the creative city but also to a ‘smart city‘ which is done the following strategies: innovation, decentralization, and collaboration.
PENGEMBANGAN KAWASAN PERMUKIMAN SUBURBAN BERBASIS TRANSIT ORIENTED DEVELOPMENT (TOD)
Authors: Octarino Christian Nindyaputra
Published: June 2020

Title: The Development of Suburb Residential Area Based on Transit Oriented Development (TOD)

The rapid growth and development of the city has impacted on the increasing of city population and traffic density which lead to various urban problems. The development of suburbs as a satellite city is considered as an appropriate solution to reduce the main city‘s load. This area could be developed into residential uses to provide living area for commuters. The railway that connects Solo and Wonogiri is considered as a major potential to create the integration between Solo as the main city and other areas as regional supports. Pasar Nguter Station is located on the route of Solo-Wonogiri railway and has great potential. The aim of this research is to examine and explore possibilities of Pasar Nguter Station to be developed as residential area based on Transit Oriented Development (TOD). This research will assess the existing condition surrounds Pasar Nguter Station based on the principal aspects of TOD such as mobility, land use, intermodal network, etc. to analyze the gap between existing and ideal conditions to formulate the most appropriate regional development strategy.
KAJIAN PANOPTISISME DAN ARSITEKTUR KONTROL DALAM PERATURAN PEMBANGUNAN GEREJA KATOLIK
Authors: De Yong Sherly
Published: June 2020

Title: Exploration of Panopticism and Architecture of Control in Building Guidance for Catholic Church

Michel Foucault introduces a mechanism to increase surveillance powers through architectural arrangement, referred to as panopticism. The connection between control of architecture and panopticismin the Catholic church is the main problem of this research. The purpose of this study is to determine the panopticism in architectural field, examine the relationship between principles of panopticism with architectural theory, especially the theory of the architecture of control, to produce a benchmark that can be used to analize the regulation in Catholic church. Through descriptive analysis and critique interpretive method, the results obtained are that panopticon and panopticism are also part of the architecture of control. From the theory of panopticon, there are six elements of panopticism can be derived (segmenting, grouping, control activities, orientation, hierarchy and control system); the most influential element in the architecture is the element of Control System. To analyze the church, we are using normative and interpretive criticism methods. The results is that the Catholic church has a system of controlling and regulating the discipline panopticism (especially panopticism supervision from the supervised vision) using the general guidance of Roman Missale as the catholic standard rules.
MEMAHAMI INTERIOR SEBAGAI PENGHUBUNG
Authors: Thamrin Diana
Published: June 2020

Title: Understanding Interior as a Connector

Interior design is a discipline that is very close to the complexities and the needs of human life. However, the intepretation and practice of interior design are often limited to decoration and contents within the physical boundaries of architecture. This paper aims to provide another perspective regarding the concept of interior that is, as a significant connector between humans and their living environment along with architecture, so that the methods and practice of interior design as well as architecture may expand more than what has been observed today. The paper is a result of a qualitative research through literature review and exploration of case studies. Results conclude to several interior and architectural design techniques based on the perception of interior as a ?connector? that could be used, such as the blurring of physical boundaries, programmatic manipulation, innovation of material continuity and configuration of architectural elements into interior elements. Through the physical as well as conceptual manipulation of space, the intepretation of interior design would no longer be limited to the contents within the physical boundaries of architecture but rather a truly important connector along with architecture, between humans and their living environment.
PENGETAHUAN DASAR DESAIN TIGA DIMENSI SEBAGAI CARA MAHASISWA DESAIN UNTUK BERPIKIR BENTUK RUANG DAN VOLUME
Authors: Putro R. Tosan Tri
Published: June 2020

Title: Three Dimensional Basic Design Knowledge as Thinking Tools for Understanding the Shape, Space and Volume

The consciousness of observing the shape and space of an object, whether large or small, is the sensitivity that becomes a designer of three-dimensional objects. A product form is created with full awareness by the designer, not by itself appearing. In addition to the function of the design object, in a design process there is a styling stage, aesthetic value visually, a form that follows the function or shape that follows the material. Aesthetic value in a design product that can not be separated from the ability of the designer with visual experience. The ability and sensitivity to observe and create an aesthetic visual form should be instilled since someone declares himself to be a designer or planner. Design areas such as architecture, interior, urban design, area and also design product are demanded for their ability to sensitize observing and design a space, volume and shape. This study is based on observations on a group of design students and literature studies. Based on observations over time, the spatial thinking capacity of each person is different, as is the ability to create an aesthetic value in a design. Everyone has different absorbtive power and creativity.
PENGARUH GAYA KOLONIAL BELANDA PADA INTERIOR RUMAH TINGGAL DI KAYUTANGAN MALANG
Authors: Setiati Grace
Published: June 2020

Title : The Influence of Dutch Colonial Style on Design Residential in Kayutangan Malang

Malang is referred to as one of the best products of colonial town planning in the Dutch East Indies. The city center of Malang in 1914 is located in the Kayutangan to Malang town square. Region Kayutangan a commercial area of Malang in the Dutch colonial occupation. Influence of development of Dutch colonial architecture included in the settlement of indigenous people, so with Kayutangan. This study aims to assess the legacy of Dutch colonial style design of houses in the area Kayutangan Malang. The research method using descriptive qualitative method with case studies. Research result shows there are significant design style colonial with the adaptation of local materials and adapted to the tropical climate in the city of Malang, there is also a mixing effects of European culture, Chinese traditional culture and the Java community. Colonial design style is manifested in the physical building with simplification of forms, according to ability, interpretation and technologies currently owned and maintained until now.
PELESTARIAN ARSITEKTUR MUSEUM SONOBUDOYO YOGYAKARTA
Authors: Handayani Titi
Published: June 2020

Title: Architectural Conservation of Sonobudoyo Museum, Yogyakarta

Sonobudoyo Museum has been experiencing many changes. More activities and collections have caused to the increasing number of rooms and new buildings. The problem is that the new building design is not suitable with the original building design and lay out by the Dutch architect, Thomas Karsten. It leads to the decreasing of the quality of the environment, even decreasing the cultural values of the museum as a heritage building. The aim of the research is to study the existing condition of Sonobudoyo Museum in order to understand changes of the original design. Evaluation of all buildings in Sonobudoyo Museum focused on their functions. Method used in this study is descriptive-qualitative. Data and findings of field surveys were analyzed in order to find the architectural characteristics of the museum and its changes. There are four conservation actions to be recommended, which are (1) preservation of buildings as their original design, (2) repairation and restoration buildings, (3) demolition of unapropriate buildings, and (4) location of new buildings.
NILAI KENUSANTARAAN ARSITEKTUR BOLA UGI MENURUT SANRO BOLA DI DUSUN KAJUARA KABUPATEN BONE
Authors: Hamka
Published: June 2020

Title: Nusantara Value of Architecture of Bola Ugi at Kajuara Village, Bone District, According to Sanro Bola

Nusantara Architecture has been apprehended as an archipelagic vernacular architecture located in the locality of cultural space. It has a tacit knowled related to traditions, values, as well as a universal and sectional significance (Pangarsa, 2006). The cultural characteristics of Nusantara architecture in Indonesia has a diverse forms, both physical and non-physical. One of archipelagic vernacular architectures in the cultural space is bola ugi architecture (Buginese House). Bola ugi has archipelagic elements associated with the values and space and physical significance. The purpose of this study was to determine the archipelagic values in bola ugi based on the knowledge possessed by the House of Bugis architect sanro bola. This research used a descriptive analysis qualitative research methodologies based on interviews of some sanro bolas and was conducted using a snow ball sampling. The results of the research showed that the archipelagic value of bola ugi included the hierarchical elements of space, room layout, orientation, and the symbol of the structure.
A Comparison of Teacher-directed and Author-directed Peer Review in a Japanese University EFL Class
Authors: Coomber Matthew
Published: June 2020

Peer review is widely-used in EFL writing classes, and it has been found that students hold generally positive attitudes towards both providing and receiving peer feedback. However, while it is common for teachers to utilize peer response worksheets, little research has looked at the impact that the specific style of these sheets can have on how language learners conduct peer review and their attitudes towards it. In this study, participants first used a generic peer response sheet designed by the teacher (teacher-directed peer review), then an individualized peer response sheet that each learner had created, focusing on specific points that they wanted advice on (author-directed peer review). Surveys were conducted after each peer review session, and the data revealed that the two peer review styles prompted peer reviewers to give different types of feedback, with a greater focus on surface level issues during author-directed peer review. Furthermore, although all students agreed that both styles had been useful, 60% stated a preference for the author-directed style.
Implicaciones antropológicas de la presencia del polimorfismo rs9282541 en los warao del delta del Orinoco, Venezuela
Authors: Castro de Guerra Dinorah , Sierra-Lovera Diana , Flores-Gutiérrez Sara , Vívenes-Lugo Merlyn
Published: June 2020

El gen ABCA1 juega un importante papel en la extracción del colesterol intracelular para la formación de la molécula de colesterol HDL. Una variante funcional de este gen, la ABCA1*230Cys (polimorfismo rs9282541), ha sido asociada con diversas alteraciones en los niveles de lípidos en sangre. Se le considera un marcador genético de origen amerindio ya que está presente solamente en nativos americanos y en poblaciones mestizas descendientes de éstos. En ellos se ha observado en frecuencias de hasta un 33 %. Aún no ha sido identificada en poblaciones estudiadas de Europa, Asia o África. Las mayores frecuencias están en Centroamérica, con un decrecimiento hacia los extremos norte y sur del continente. En Venezuela no existen estudios del polimorfismo rs9282541, por lo que no ha sido posible realizar comparaciones con grupos del resto del continente. Con ese interés, el objetivo de la presente investigación fue identificar la frecuencia del ABCA1*230Cys en los warao del delta del río Orinoco (Edo. Delta Amacuro, Venezuela, N=115) y compararla con distancias genéticas reportadas en otros grupos americanos, para aportar información útil a la discusión sobre su origen genético. La frecuencia alélica obtenida fue del 13,05 %, valor intermedio en relación con lo reportado para otros grupos indígenas. Los valores de distancia genética entre warao y el resto de las poblaciones amerindias portadoras del polimorfismo permitieron establecer semejanzas con grupos de origen proto-chibcha y otros cazadores-recolectores del norte del Amazonas de diferente origen lingüístico. La presencia de esa variante amerindia originada en Centroamérica establece una conexión remota con grupos nativos o procedentes de esa región. Estos resultados dan cuenta de la importancia de este tipo de estudios, que integran datos genéticos e históricos, para mejorar el nivel de discusión sobre el origen de las poblaciones indígenas americanas, además de valorar la utilidad de la variante ABCA1*230Cys para establecer vínculos genéticos entre poblaciones de interés. Este es el primer reporte del polimorfismo rs9282541 del gen ABCA1 en poblaciones indígenas venezolanas.
Estudio de la variación secular en la talla de poblaciones humanas del centro de Argentina durante el Holoceno tardío
Authors: Loupias Luciano , Fabra Mariana
Published: June 2020

El objetivo de este trabajo es estudiar la variación secular en la talla de las poblaciones humanas que habitaron el centro de Argentina a lo largo del Holoceno tardío. Se espera encontrar una variación en la estatura y una disminución en el dimorfismo sexual en talla, asociado a los cambios en los modos de vida y las estrategias de subsistencia. Esto último relacionado con la transición de la caza y la recolección a una economía de tipo mixta, que complementa a la primera con la producción de alimentos. La muestra está compuesta por 42 individuos (18 femeninos, 24 masculinos), todos con información radiocarbónica asociada mediante AMS, que los sitúa entre 4058-387 14C años AP. Se registraron estaturas promedio altas para individuos femeninos (163,4 cm para fémur) y medianas para masculinos (168,3 cm para fémur). Los resultados, contrarios a las expectativas iniciales, sugieren un aumento del dimorfismo sexual a lo largo del tiempo, producto de una tendencia secular negativa de la talla en individuos femeninos y una leve tendencia al incremento de la estatura en masculinos. Las tendencias observadas en distintas regiones y por sexo no pueden ser explicadas atendiendo a un único factor explicativo. Más bien, la conjunción de causas ambientales y genéticas pueden estar interviniendo en los procesos que modelan la talla de los individuos a lo largo del tiempo.
Ética y consulta previa
Authors: Figueroa Isabela
Published: June 2020

En julio del 2018 la Universidad del Magdalena (Santa Marta, Colombia) puso en funcionamiento el Comité de Ética en Investigación.  Ese Comité queda encargado de “evaluar, conceptuar y dar seguimiento, desde el punto de vista ético, a los proyectos de investigación que presente y desarrolle la Universidad, cuando en su objeto o método se intervenga con la salud o la vida (humana o no humana), o con el medio ambiente o la biodiversidad.” Entre sus funciones, está la de garantizar que los proyectos de investigación respeten a las personas y comunidades participantes de los proyectos.

El semestre pasado el Comité de Ética analizó un proyecto de investigación elaborado por mí, en calidad de docente investigadora de la Unimagdalena.  El proyecto pretende identificar de qué manera la Corte Constitucional de Colombia reconoce (o no) derechos territoriales de los pueblos indígenas sobre porciones del mar.  Como método de trabajo, fueron previstas dos entrevistas grupo-focal en dos comunidades pesqueras wayúu en la provincia de la Guajira. Las autoridades comunales de ambas comunidades tienen conocimiento de esa propuesta de investigación, que fue elaborada en diálogo con sus líderes.  El proyecto presentado incluyó los formatos de consentimiento previo e informado a ser firmado por cada participante del grupo focal, con el previo consentimiento de sus autoridades tradicionales.
Vulnerability of Regional Economies’ Structure in Crisis Conditions
Authors: Kuznetsova O. V.
Published: June 2020

The impact of coronavirus on the socio-economic development of Russian regions inevitably depends on the structure of their economy, which is analyzed in the article on the basis of official data on the employment structure. The contribution of different sectors of the economy (primary, secondary, and tertiary), the role of informal employment and the budget sector, and the share of employment in the most affected industries are evaluated. Not only short-term, but also long-term structural problems of the regional economy are highlighted. It is shown that the negative impact of coronavirus mainly on the service sector in the context of the Russian Federation subjects is evident in federal cities, in economically underdeveloped regions with an underdeveloped real sector of the economy, as well as regions that specialize in certain types of services (tourism, foreign trade, complex services). For economically underdeveloped regions, the impact of coronavirus is deepened by a high share of the informal sector (which limits the possibility of obtaining state support), but is softened by an increased share of employees who receive wages from the budget system. The reduced share of the service sector in agricultural regions means that they are less dependent on coronavirus, but it confirms the need to develop the service sector as a basis for improving the quality of life of the population. At the same time, almost everywhere there is a need to restructure the service sector: reducing the role of simple services (primarily trade), in favor of complex ones related to high technologies and innovations and to the social sphere, especially health.
“Concept 2020” and the Lessons of the Crisis Development
Authors: Bukhvald E. M.
Published: June 2020

“The Concept of long-term socio-economic development of the Russian Federation for the period up to 2020”, adopted in 2008 (hereinafter - the Concept), reasonably can be considered as one of the most significant - since the beginning of economic reforms in Russia – attempt to form an idea of the long-term prospects for socio-economic development of the country, as well as the necessary steps to ensure the stability of this development. The document is characterized by a systematic vision of the actual and perspective trends in the economic and social development of the country; the desire to use a scenario approach in setting the goals of the Concept; the intention to provide the formulated priorities with the necessary economic resources, institutional and legal innovations. Among these items of fundamental importance is the policy of developing economic and legal mechanism of federal relations and priorities’ setting for the state policy of regional development. After the Concept was adopted (this document is currently listed as valid in all databases), it was changed several times. The nature of these changes is very different, but their general vector is clearly visible: to remove from the document those benchmarks, targets, etc., which quite soon after the adoption of the document appeared to be clearly unattainable. The article discusses some of the key items of the Concept and the reasons why the document was not implemented.
The Electron Effect of Aromatic Group: Control Conformation of 2-Aromatic Cyclododecanone Derivatives
Authors: Mingyan Yang , Daoquan Wang , Mingan Wang
Published: June 2020

2-Phenylcyclododecanone and 2-cyclohexylcyclododecanone derivatives were
synthesized and characterized by 1H NMR, 13C NMR, HR-ESI-MS and X-ray diffraction.
Their preferred conformations were analyzed by the coupling constants in the 1H NMR
spectra and X-ray diffraction, which showed the skeleton ring of these derivatives containing
[3333]-2-one conformation, and the phenyl groups were located at the side-exo position
of [3333]-2-one conformation due to the strong π-π repulsive interaction between the π-
electron of benzene ring and π-electron of carbonyl group. The cyclohexyl groups were
located at the corner-syn or the side-exo position of [3333]-2-one conformation depending
on the hindrance of the other substituted groups. The π-π electron effect played a crucial role in
efficiently controlling the preferred conformation of 2-aromatic cyclododecanone and the other
2-aromatic macrocyclic derivatives with the similar preferred square and rectangular conformations.
Mesenchymal Stem Cells: A New Generation of Therapeutic Agents as Vehicles in Gene Therapy
Authors: Gharbavi Mahmoud , Sharafi Ali , Ghanbarzadeh Saeed
Published: June 2020

In recent years, mesenchymal stem cells (MSCs) as a new tool for therapeutic gene delivery
in clinics have attracted much attention. Their advantages cover longer lifespan, better isolation, and
higher transfection efficiency and proliferation rate. MSCs are the preferred approach for cell-based
therapies because of their in vitro self-renewal capacity, migrating especially to tumor tissues, as well
as anti-inflammatory and immunomodulatory properties. Therefore, they have considerable efficiency
in genetic engineering for future clinical applications in cancer gene therapy and other diseases. For
improving therapeutic efficiency, targeted therapy of cancers can be achieved through the sustained
release of therapeutic agents and functional gene expression induction to the intended tissues. The development
of a new vector in gene therapy can improve the durability of a transgene expression. Also,
the safety of the vector, if administered systemically, may resolve several problems, such as durability
of expression and the host immune response. Currently, MSCs are prominent candidates as cell vehicles
for both preclinical and clinical trials due to the secretion of therapeutic agents in several cancers.
In the present study, we discuss the status of gene therapy in both viral and non-viral vectors along
with their limitations. Throughout this study, the use of several nano-carriers for gene therapy is also
investigated. Finally, we critically discuss the promising advantages of MSCs in targeted gene delivery,
tumor inhibition and their utilization as the gene carriers in clinical situations.
PTML Modeling for Alzheimer’s Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6
Authors: Kleandrova Valeria V. , Speck-Planche Alejandro
Published: June 2020

Background:

Alzheimer’s disease is characterized by a progressive pattern of cognitive and
functional impairment, which ultimately leads to death. Computational approaches have played an important
role in the context of drug discovery for anti-Alzheimer's therapies. However, most of the computational
models reported to date have been focused on only one protein associated with Alzheimer's,
while relying on small datasets of structurally related molecules.

Objective:

We introduce the first model combining perturbation theory and machine learning based on
artificial neural networks (PTML-ANN) for simultaneous prediction and design of inhibitors of three
Alzheimer’s disease-related proteins, namely glycogen synthase kinase 3 beta (GSK3B), histone deacetylase
1 (HDAC1), and histone deacetylase 6 (HDAC6).

Methods:

The PTML-ANN model was obtained from a dataset retrieved from ChEMBL, and it relied on
a classification approach to predict chemicals as active or inactive.

Results:

The PTML-ANN model displayed sensitivity and specificity higher than 85% in both training
and test sets. The physicochemical and structural interpretation of the molecular descriptors in the model
permitted the direct extraction of fragments suggested to favorably contribute to enhancing the multitarget
inhibitory activity. Based on this information, we assembled ten molecules from several fragments
with positive contributions. Seven of these molecules were predicted as triple target inhibitors while the
remaining three were predicted as dual-target inhibitors. The estimated physicochemical properties of
the designed molecules complied with Lipinski’s rule of five and its variants.

Conclusion:

This work opens new horizons toward the design of multi-target inhibitors for anti- Alzheimer's
therapies.
Computer-Aided Drug Design Applied to Secondary Metabolites as Anticancer Agents
Authors: de Araújo Rodrigo Santos Aquino , da Silva-Junior Edeildo Ferreira , de Aquino Thiago Mendonça , Scotti Marcus Tullius , Ishiki Hamilton M. , Scotti Luciana , Mendonça-Junior Francisco Jaime Bezerra
Published: June 2020

:

Computer-Aided Drug Design (CADD) techniques have garnered a great deal of attention in
academia and industry because of their great versatility, low costs, possibilities of cost reduction in in
vitro screening and in the development of synthetic steps; these techniques are compared with highthroughput
screening, in particular for candidate drugs. The secondary metabolism of plants and other
organisms provide substantial amounts of new chemical structures, many of which have numerous biological
and pharmacological properties for virtually every existing disease, including cancer. In oncology,
compounds such as vimblastine, vincristine, taxol, podophyllotoxin, captothecin and cytarabine are
examples of how important natural products enhance the cancer-fighting therapeutic arsenal.

:

In this context, this review presents an update of Ligand-Based Drug Design and Structure-Based Drug
Design techniques applied to flavonoids, alkaloids and coumarins in the search of new compounds or
fragments that can be used in oncology.

:

A systematical search using various databases was performed. The search was limited to articles published
in the last 10 years.

:

The great diversity of chemical structures (coumarin, flavonoids and alkaloids) with cancer properties,
associated with infinite synthetic possibilities for obtaining analogous compounds, creates a huge
chemical environment with potential to be explored, and creates a major difficulty, for screening studies
to select compounds with more promising activity for a selected target. CADD techniques appear to be
the least expensive and most efficient alternatives to perform virtual screening studies, aiming to selected
compounds with better activity profiles and better “drugability”.
A Comprehensive Systemic Literature Review of Pericardial Decompression Syndrome: Often Unrecognized and Potentially Fatal Syndrome
Authors: Amro Ahmed , Mansoor Kanaan , Amro Mohammad , Sobeih Amal , Suliman Mohamed , Okoro Kelechukwu , El-Hamdani Rawan , Vilchez Daniel , El-Hamdani Mehiar , Shweihat Yousef R.
Published: June 2020

Background:

Pericardial Decompression Syndrome (PDS) is defined as paradoxical
hemodynamic deterioration and/or pulmonary edema, commonly associated with ventricular dysfunction.
This phenomenon was first described by Vandyke in 1983. PDS is a rare but formidable
complication of pericardiocentesis, which, if not managed appropriately, is fatal. PDS, as an entity,
has discrete literature; this review is to understand its epidemiology, presentation, and management.

Methodology:

Medline, Science Direct and Google Scholar databases were utilized to do a systemic
literature search. PRISMA protocol was employed. Abstracts, case reports, case series and
clinical studies were identified from 1983 to 2019. A total of 6508 articles were reviewed, out of
which, 210 were short-listed, and after removal of duplicates, 49 manuscripts were included in this
review. For statistical analysis, patient data was tabulated in SPSS version 20. Cases were divided
into two categories surgical and percutaneous groups. t-test was conducted for continuous variable
and chi-square test was conducted for categorical data used for analysis.

Results:

A total of 42 full-length case reports, 2 poster abstracts, 3 case series of 2 patients, 1 case
series of 4 patients and 1 case series of 5 patients were included in the study. A total of 59 cases
were included in this manuscript. Our data had 45.8% (n=27) males and 54.2% (n=32) females.
The mean age of patients was 48.04 ± 17 years. Pericardiocentesis was performed in 52.5% (n=31)
cases, and pericardiostomy was performed in 45.8% (n=27). The most common identifiable cause
of pericardial effusion was found to be malignancy in 35.6% (n=21). Twenty-three 23 cases reported
pre-procedural ejection fraction, which ranged from 20%-75% with a mean of 55.8 ± 14.6%,
while 26 cases reported post-procedural ejection fraction which ranged from 10%-65% with a mean
of 30% ± 15.1%. Data was further divided into two categories, namely, pericardiocentesis and pericardiostomy.
The outcome as death was significant in the pericardiostomy arm with a p-value of <
0.00. The use of inotropic agents for the treatment of PDS was more common in needle pericardiocentesis
with a p-value of 0.04. Lastly, the computed recovery time did not yield any significance
with a p-value of 0.275.

Conclusion:

Pericardial decompression syndrome is a rare condition with high mortality. Operators
performing pericardial drainage should be aware of this complication following drainage of cardiac
tamponade, since early recognition and expeditious supportive care are the only therapeutic modalities
available for adequate management of this complication.
Phytochemical Composition and Antioxidant Activity of Trichoderma reesei Degraded Date (Phoenix dactylifera L.) Pits
Authors: Alyileili Salem R. , Hussein Ahmed S. , Ibrahim Wissam , El-Tarabily Khaled A.
Published: June 2020

Background:

Date palm (Phoenix dactylifera L.) is a dominant fruit crop in most of the Arabian
countries. Date pits, as a major byproduct which remained after consumption of date flesh proved
to be valuable source of energy.

Methods:

Solid State Degradation (SSD) system was used for the preparation of degraded date pits.
Date pits degraded with Trichoderma reesei were evaluated for their proximate, chemical composition
and antioxidant activity.

Results:

The crude fiber content of degraded date pits was found to be 20.8 %, ash (2.09%), crude fat
(7.2%), protein (5.56%), and total carbohydrate (87.2%). Neutral detergent fiber (NDF) and acid detergent
fiber (ADF) was found to be 74.6% and 45.7%, respectively. Monosaccharide composition of fiber
showed that the degradation with T. reesei significantly (P<0.05) enhanced the glucose and mannose
content of cellulose, hemicellulose and lignin. Pectin, total carbohydrate and mannan oligosaccharide
content were also increased in degraded date pits in which galactose and mannose were the major neutral
sugars. Among the studied minerals, potassium, calcium, magnesium, sulphur and phosphorus were
predominant. The phenolic and flavonoid contents of degraded date pits significantly (P<0.05) increased
to 14.230 g Gallic equivalent/100g DW and 11.68 g Rutin equivalent /100g DW. Degraded date pits
also showed significant antioxidant activity as evidenced by the results of 2,2-diphenyl-1-
picrylhydrazyl(DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline 6 sulphonicacid) (ABTS) and Ferric Reducing
Antioxidant Power (FRAP) assays.

Conclusion:

Biological degradation with T. reesei significantly (P<0.05) improved the nutritional effect
of date pits and thereby its potential usage in food industry was greatly improved.
MK-FSVM-SVDD: A Multiple Kernel-based Fuzzy SVM Model for Predicting DNA-binding Proteins via Support Vector Data Description
Authors: Zou Yi , Wu Hongjie , Guo Xiaoyi , Peng Li , Ding Yijie , Tang Jijun , Guo Fei
Published: June 2020

Background:

Detecting DNA-binding proteins (DBPs) based on biological and chemical
methods is time-consuming and expensive.

Objective:

In recent years, the rise of computational biology methods based on Machine Learning
(ML) has greatly improved the detection efficiency of DBPs.

Method:

In this study, the Multiple Kernel-based Fuzzy SVM Model with Support Vector Data
Description (MK-FSVM-SVDD) is proposed to predict DBPs. Firstly, sex features are extracted
from the protein sequence. Secondly, multiple kernels are constructed via these sequence features.
Then, multiple kernels are integrated by Centered Kernel Alignment-based Multiple Kernel
Learning (CKA-MKL). Next, fuzzy membership scores of training samples are calculated with
Support Vector Data Description (SVDD). FSVM is trained and employed to detect new DBPs.

Results:

Our model is evaluated on several benchmark datasets. Compared with other methods, MKFSVM-
SVDD achieves best Matthew's Correlation Coefficient (MCC) on PDB186 (0.7250) and
PDB2272 (0.5476).

Conclusion:

We can conclude that MK-FSVM-SVDD is more suitable than common SVM, as the
classifier for DNA-binding proteins identification.
Trend Linking of Multiple System Atrophy: A Scientometric Study
Authors: Khazaneha Mahdiyeh , Osareh Farideh , Shafiee Kaveh
Published: June 2020

Aim:

This study aims to add to previous analyses and describe the trends in MSA research
from three decades, 1988 to 2018, through assessing the medical literature. Additionally, a collaboration
network was analyzed to determine the most common process in development of MSA research.

Methods:

This research was a descriptive survey with a scientometric approach. The data for the present study were collected from the Web of Science (WoS) and search strategy based on Medical Subject Heading (MeSH) term. In this research, the data analysis was performed based on collaboration
network and theme analysis.

Results and Conclusion:

In this study, 6530 articles were retrieved from 1988 to 2018 divided in three
different periods. These articles were drafted by 39,184 authors, 3,865 organizations, 80 countries, and
832 journals. Further, 287 articles with more than 100 citations were found. The global citation score
(GCS) was 250,834 times and the average citations per article was 3,841 times. The MSA research
field demonstrated a diagram for a chronological period to assess the most relevant themes. Each diagram depended on the sum of documents linked to each research topic. Scientometric analysis of the
field of MSA can be regarded as a roadmap for future research and policymaking in this important
area.
The Multi Steps Synthetic Methods of (±)-Indolizidine 209D as an Amphibian Natural Product in the Family of Alkaloids
Authors: Mohajer Fatemeh , Ziarani Ghodsi Mohammadi , Taghipour Fatemeh
Published: June 2020

(±)-Indolizidine 209D is one of the alkaloids isolated from the skin secretions of certain
neotropical frogs and exhibit a range of pharmacological properties, including blocking neuromuscular
transmission. Therefore, the synthesis of indolizidine 209D and more complex derivatives, have
been the subject of several publications. The preparation pathways of indolizidine 209D and its derivatives
are the subject of this review. In this paper, some highly regio- and stereoselective functionalization
process were reviewed through the synthesis of the optically active (±)-indolizidine
209D.
Theaflavin Enriched Black Tea Extract Alleviates Diabetic Nephropathy by Suppressing Hyperglycaemia-Mediated Oxidative Stress and Inflammation in Streptozotocin-Induced Rats
Authors: Sarkar Dhrubajyoti , Bose Sekhar Kumar , Chakraborty Tania , Roy Souvik
Published: June 2020

Background:

Diabetic Nephropathy (DN), a microvascular complication of diabetes has
been a significant health issue globally. However, theaflavin enriched black tea extract (BTE-TF)
could restrain DN.

Objective:

The main objective of this exploration was to elucidate the effect of BTE-TF on DN,
though the underlying mechanism remains unclear and requires further investigation.

Methods:

The tea leaves were fermented to get black tea extract. Total phenolic content and HPLC
were carried out to determine the phenolic content and theaflavin in the extract. Streptozotocin induced
diabetic rats were treated with 100, 200, and 400 mg/kg/day BTE-TF extract for 12 weeks.
Biochemical parameters like blood glucose, creatinine, Blood Urea Nitrogen (BUN), triglyceride and
antioxidant parameters of kidney tissue were measured. Histology, immunohistochemistry and
TUNEL assay were performed to observe the effect of the extract with comparison to the standard
drug (Metformin 200mg/kg/day).

Result:

Treated animals exhibited reduced blood glucose levels, blood urea nitrogen (BUN), creatinine,
and serum triglycerides. Further, BTE-TF restored the histological alterations in the kidney.
Chronic hyperglycaemia resulted in a significant increase in oxidative stress and pro-inflammatory
cytokines of NF-kβ pathway. BTE-TF attenuated oxidative stress (p<0.01), inflammation (p<0.05)
and apoptosis (p<0.05).

Conclusion:

This study suggests that BTE-TF exerts a protective role against diabetes-induced renal
injury by ameliorating oxidative stress, inflammation, and apoptosis.
Method and System for Testing the Working Characteristics of Vehicle Fuel Injector
Authors: Liu Bin , Li Yanhao , Han Fangfang , Qiao Qian , Li Jianwen
Published: June 2020

Background:

The vehicle fuel injector directly affects the power performance, emission
characteristics and economic efficiency of the engine. At present, several testing standards are stipulated
on accurate measurement of the working characteristics of fuel injectors.

Objective:

The purpose of this study is to provide an efficient patent about the method and system for
testing the working characteristics of a vehicle fuel injector.

Methods:

Two key techniques are significant to establish a standard test environment. The patent about
the pressure control approach and the injector driving method was proposed. The adaptive fuzzy PID
approach was applied to control pressure. An adaptive multi-functional driver was designed and developed
for both the voltage-driven and current-driven port fuel injectors.

Results:

The experiments on the two key technologies were conducted. During the dynamic flow test,
the settling time using the system was 1ms. For the static flow test, the settling time was 1 s. The
maximum changing rate of pressure fluctuation was 1%. Then, the system was verified by test on the
flow characteristics and dynamic response of the voltage-driven and current-driven injectors. The linear
deviation of each dynamic flow curve was between ± 3% to ± 6%. Furthermore, the deviation of the
dynamic flow curves from the repeated test was small. The maximum deviation of the static flow results
was less than 4% and the dynamic response of the injector varied with the change of the pressure.

Conclusion:

The system meets the requirements of the related standards. The experimental results
prove that the system is stable and reliable.
4,4′-Isopropylidenebis(2,6-dibromophenol) Photocatalytic Debromination on Nano- and Micro-Particles Fe3O4 Surface
Authors: Kisała Joanna , Tomaszewska Anna , Pogocki Dariusz
Published: June 2020

Background:

Tetrabromobisphenol A (4,4’-isopropylidenebis(2,6-dibromophenol), TBBPA)
is one of the most widely used brominated flame retardants. Due to its widespread use, high lipophilicity,
and persistence, it has been detected in various environmental samples. Therefore, it is of
great significance to develop methods to efficiently remove TBBPA from the contaminated environment.

Objective:

The aim of our study was to examine photocatalytic dehalogenation of TBBPA on microand
nano-sized Fe3O4 exposed to the visible light. The Fe3O4 catalyst was chosen due to its indisputable
low impact on the environment.

Methods:

A solution of TBBPA (1.84 × 10-4 mol dm-3) with a pH = 8 with suspended catalyst was illuminated
(light intensity about 1.1x1017 photons per second, spectrum range 200-600 nm) for 1 hour.
Analysis of the reaction progress was carried out by HPLC measurements of TBBPA decay and potentiometric
measurements of an increase in bromide concentration.

Results:

The degradation process seems to be the most effective for TBBPA in the reaction mixture
containing the n-Fe3O4 (t0.5 ≈ 2 min). Slightly lower degradation efficacy is observed for TBBPA degradation
in the presence of the μ-Fe3O4 (decay within the first 5 min). TBBPA decomposition of both
n-Fe3O4 and μ-Fe3O4 is accompanied by different bromide concentrations time-profile.

Conclusion:

The photogenerated electron-induced degradation by dissociative-attachment to the aromatic
ring was followed by bromine ion expulsion. The micro-magnetite showed a strong tendency
for adsorption of bromide anions during the process, which could be adventurous for the overall
waste-decontamination process.
Extreme methods of localizing a noise source using a network of distributed sensors
Authors: Dzhavadov N. G. , Asadov K. G. , Kazymly R. V.
Published: June 2020

Wireless networks of distributed sensors are used to study natural resources, track various targets, monitor hard-to-reach areas, etc. Unattended sensors are randomly distributed on the territory using various technical means. The research aims to develop an extreme method for localizing a noise source. The developed method is based on the proposed principle of extreme localization of a noise source using a network of distributed fixed receivers. The following varieties of the proposed principle are considered: an extreme method of localizing a noise signal source using a network of distributed tunable sensors; a method of selecting wavelengths by the distance between the transmitter and receiver. The mathematical substantiation of the methods using the mathematical procedure of unconditional variational optimization is given. The algorithms for the implementation of the proposed methods are compiled.
More on assessing the probability of radar information association during tertiary information processing in network structures
Authors: Palguev D. A. , Shentyabin A. N.
Published: June 2020

The use of network structures in information systems allows for single-level tertiary processing of radar information. This feature makes it possible to significantly reduce the time of delivery of information from sources to consumers, as well as rigorously determine mathematically the probability of combining information during tertiary processing in network structures. The article contains mathematical expressions for assessing the probability of combining information during tertiary processing from incoherent spatially separated sources. Determining the size of the strobe for accurate selection by the given probability of combining information using the tertiary network processing algorithm allows reducing the number of calculations in the subsequent pairwise comparison of messages due to the reduction of the size of the strobe. Such an approach creates the conditions for building a cognitive model of radar data processing in modern information systems. The reduction of data processing intervals in an information system increases the accuracy and reliability of information transmitted to consumers. The resulting mathematical expressions can be used to assess the reliability of the information in mathematical models of network information systems.
Using information processing algorithms that factor in the effect of secondary modulation of radar signals
Authors: Bratkov V. A. , Sentsov A. A. , Polyakov V. B.
Published: June 2020

The article provides an assessment of the impact the dynamic structures of power systems of aircraft systems have on the spectrum of the reflected radar signal. In the conditions of autonomous actions of the fighter, the tasks of long-range detection of airborne targets are assigned directly to the onboard radar station. It is necessary to resolve the contradictions associated with increasing the detection range without changing the energy indicators of the onboard radar station. This is possible by optimizing the processing of many spectral components of the signal reflected from the propeller and turboprop engine of airborne targets. The location of propeller reflections in the spectrum of the reflected signal is determined by the technical parameters of the power plant and its mode of operation. The percent of the total energy of the reflected signal spectrum outside the main spectral component is comparable with the energy reflected from the airframe of the aviation complex, most of which is the energy reflected from the rotating elements of power plants. Therefore, the development of an algorithm for detecting a signal with a complex spectral structure that maximizes the probability of detection under time and computational resources restrictions is a very relevant scientific task. The scientific novelty lies in the development of an algorithm for detecting a signal with a complex spectral structure and its detection characteristics taking the effect of secondary modulation into account as well as in the development of practical recommendations for optimizing algorithms for detecting airborne targets. Using the developed algorithm in the fighter’s pulse-Doppler radar station will increase the detection range of an air target against the background of interfering reflections from the water surface.