bluuebunny/crossref_metadata_2025 huggingface dataset:
Level of Mental Health Among Physical Education Teachers During COVID-19 Pandemic
Authors: Zainol Azlan Nur Zaheeda , Zolkafi Mohd Azrul Anuar , Kasim Nor Fadila
Published: January 2025

This study aims to investigate the status of mental health among Physical Education (PE) teachers Gombak, Selangor during the pandemic of Covid-19A total of 124 primary school PE teachers in Gombak district were selected randomly to be sampled for this study. A set of questionnaires consisted of three sections covering the background of the respondent, a section for measuring the level of mental health using the Depression, Anxiety and Stress Scale (DASS-21) instrument and a section using Global Physical Activity Questionnaire Malay Version (GPAQ-M) instrument translation by Soo et al. (2015) to measure the physical level of activity by focusing on the teachers sedentary. The data were analysed using Statistic Packages for Social Science (SPSS) version 22.0 involved descriptive statistics and inference analysis. The result showed that the teacher’s mental health in depression was at normal levels, while anxiety and stress level were moderate. Furthermore, the result show that there is a significant positive relationship between the anxiety (r=0.322, p=0.000) and stress (r=0.240, p=0.007) with sedentary level. While the depression (r=-0.121, p=0.180) showed no significant association with sedentary level. In conclusion, the mental health status among PE teachers during the pandemic of Covid-19 was normal and not worrying.
Analysis of Goal Scoring Period in Major European Football League Winners 2019/2020
Authors: Ahmad Mohd Faridz , Rosli Danish , Md Japilus Siti Jameelah , Nor Azmi Abdul Muiz , Hassan Nor Sadzali
Published: January 2025

European football league (e.g., La Liga, Bundesliga, Serie A, etc.). Football matches are divided into two halves. At the end of the game, the number of goals scored can be used to determine the winner. Therefore, the objective of this study was to analyze and compare the goals scored between the first half and second half period among the winners of each top European League 2019/2020 competition. The Mann-Whitney U test was used to evaluate a total of 406 goals from 175 games from the official website and YouTube highlights. Only Liverpool, England's Premier League, showed more goals in the first half, whereas the majority of the winners—Real Madrid, Spain's La Liga, Juventus, Italy's Serie A TIM, Bayern Munich, Germany's Bundesliga, and Paris Saint-German, France's Ligue 1 Uber Eats—scored more goals in the second half. The results indicated that there were significant differences in goals scored between the first and second half periods in La Liga and Serie A TIM, p < .05. In conclusion, Real Madrid and Juventus fully utilized the disadvantages of their opponents to score a goal to win a match and competition. As the time moves towards the end of the matches, the player’s fitness components, mental aspect, and team tactical become the crucial factors of team differentiation. This study recommends comparing goal scoring across several continents in the future.
Analysis Use Preposition VON and AUS In Indonesian
Authors: Anggraini Vita , Nnko Godwin Ulick , Zikri Mona
Published: January 2025

Purpose of the study : Research This aiming For understand the meaning produced by the preposition von and aus in various situation communication . Pragmatics focus on usage Language in context real , so that can give outlook about How preposition This used For convey appropriate meaning​ with situation communication.
Methodology: Research This use method descriptive qualitative For analyze preposition from and worn out in Indonesian . Data obtained from text translation , interview informants , and observations conversation . Analysis covers data reduction , classification function preposition , interpretation contextual , and triangulation For ensure validity results .
Main Findings: Research This find that von more often used for show origin or connection ownership, while aus referring to the material or origin physical. Error translation often happen consequence translation literally, as in the sentence I am like that from Germany , which is more appropriate translated as "I come from from Germany" rather than "I'm coming from Germany". In pragmatics, by refers to the relationship abstract, whereas worn out more describe connection physique or material. Structure more Indonesian​ flexible prioritize context conversation, not rule grammatical strict .
Novelty/Originality of this study: Novelty study This lies in the approach holistic that combines analysis translation, interviews , and observations For understand use preposition in context real. Research this also highlights importance understanding pragmatic in translation and providing contribution to teaching German and Indonesian, especially in avoid error general and understanding difference culture as well as linguistics between second language.
Perspektif Islam tentang Perubahan Iklim
Authors: Mursalin Hisan , Mu’ti Abdul , Amirrachman Alpha
Published: January 2025

Perubahan iklim merupakan salah satu tantangan global yang berdampak luas terhadap ekosistem bumi dan kehidupan manusia. Dalam perspektif islam, perubahan iklim merupakan fenomena alam yang memerlukan perhatian serius karena dampaknya terhadap kesejahteraan umat manusia dan kelestarian alam. Studi awal ini bertujuan untuk mengemukakan pandangan Islam mengenai perubahan iklim, dengan fokus pada pemahaman etika lingkungan dan tanggung jawab manusia sebagai khalifah (pengelola) bumi. Oleh karena itu, tantangan perubahan iklim harus diatasi melalui upaya bersama yang meliputi pengurangan emisi karbon, pelestarian sumber daya alam, dan advokasi untuk keadilan sosial dalam konteks lingkungan. Metode yang digunakan ialah pendekatan kualitatif, data yang didapat dari website, perpustakaan online, buku, dan jurnal. Hasil utama dari penelitian ini menunjukkan bahwa Islam mengajarkan pentingnya menjaga keseimbangan alam dan mendorong umatnya untuk berperan sebagai pelindung bumi. Prinsip-prinsip etika lingkungan dalam Islam menegaskan bahwa manusia memiliki tanggung jawab moral untuk menjaga alam sebagai amanah dari Allah SWT. Dan semoga tulisan ini dapat memberikan kontribusi pada pemahaman tentang peran agama dalam konteks perubahan iklim global.
Climate change is one of the global challenges that has a wide impact on the earth's ecosystem and human life. From an Islamic perspective, climate change is a natural phenomenon that requires serious attention because of its impact on the welfare of mankind and the preservation of nature. This initial study aims to put forward the Islamic view on climate change, focusing on the understanding of environmental ethics and human responsibility as khalifah (manager) of the earth. Therefore, the challenges of climate change must be addressed through joint efforts that include reducing carbon emissions, conserving natural resources, and advocating for social justice in the environmental context. the method used is a qualitative approach, data obtained from websites, online libraries, books and journals. The main results of this study show that Islam teaches the importance of maintaining the balance of nature and encourages its people to play a role as protectors of the earth. The principles of environmental ethics in Islam emphasize that humans have a moral responsibility to protect nature as a mandate from Allah SWT. And hopefully this paper can contribute to the understanding of the role of religion in the context of global climate change.
Demokrasi dan Kebijakan Publik dalam PP Nomor 21 Tahun 2024 Tentang Tabungan Penyelenggaraan Perumahan Rakyat
Authors: Nur Khaliq Muhammad
Published: January 2025

Penelitian ini bertujuan untuk menganalisis implikasi Peraturan Pemerintah (PP) No. 21 Tahun 2024 tentang Tabungan Perumahan Rakyat (Tapera) terhadap demokrasi dan kebijakan publik di Indonesia. Kebijakan ini dikeluarkan sebagai upaya pemerintah dalam meningkatkan akses masyarakat, khususnya yang memberikan dampak rendah, terhadap perumahan yang layak. Namun dalam proses pengurusannya, minimnya keterlibatan publik dan kurangnya transparansi menjadi isu penting yang mempengaruhi kualitas demokrasi partisipatif. Penelitian ini juga menemukan bahwa meskipun kebijakan ini berpotensi memberikan solusi jangka panjang untuk masalah perumahan, implementasinya harus disertai dengan peningkatan mekanisme akuntabilitas dan keterbukaan agar sesuai dengan nilai-nilai demokrasi. Partisipasi masyarakat dalam proses pengambilan keputusan kebijakan publik perlu ditingkatkan untuk memastikan bahwa kebijakan yang dihasilkan bersifat inklusif dan berkeadilan
This research aims to analyse the implications of Government Regulation (PP) No. 21 Year 2024 on Public Housing Savings (Tapera) on democracy and public policy in Indonesia. This policy was issued as part of the government's efforts to improve access to decent housing for people, especially those with low-income. However, in the process, the lack of public involvement and lack of transparency are important issues that affect the quality of participatory democracy. This research also found that although this policy has the potential to provide a long-term solution to the housing problem, its implementation must be accompanied by improved accountability and openness mechanisms to be in line with democratic values. Community participation in the public policy decision-making process needs to be increased to ensure that the resulting policies are inclusive and equitable
PENGARUH EKONOMI NASIONAL DISELENGGARAKAN BERDASARKAN DEMOKRASI EKONOMI DENGAN PRINSIP KEBERSAMAAN EFESIENSI BERKEADILAN BERKELANJUTAN DAN BERWAWASAN LINGKUNGAN DI DINAS KOPERASILABUHANBATU
Authors: Harahap Sulaiman Juhdi , Nasution Ade Parlaungan , Halim Abdul
Published: January 2025

Penelitian ini di Lakukan di Dinas Kabupaten Labuhanbatu dengan menggunakan metode kuantitatif. Populasi yang digunakan adalah seluruh karyawan yang ada di Dinas Koperasi Kabupaten Labuhanbatu yang berjumlah 33 Karyawan. Metode pengumpulan data penyebaran angket, dokumentasi dan wawancara. Hasil penelitian menyatakan bahwasanya adanya pengaruh ekonomi Nasional terhadap wawasan lingkungan,adanya pengaruh Demokrasi Ekonomi terhadap wawan lingkungan, dan Prinsif Kebersamaan Efesiensi berkeadilan terhadap wawasan lingkungan. Dari hasil Uji Statistik Regresi Linier Berganda diperoleh persamaan
Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota
Authors: Qiu Yi-Tong , Luo Xin-Yi , Deng Ya-Feng , Zheng Xue , Qiu Jian-Guo , Zhang Lin-Sheng , Huang Xiao-Qi , Zheng Xue-Bao , Huang Hai-Yang
Published: January 2025

BACKGROUND

Modified Pulsatilla decoction (PD), a PD with licorice and ejiao, is a classic Traditional Chinese Medicine formula with significant efficacy in treating intestinal mucositis (IM) induced by tumor therapy. However, its specific molecular and biological mechanisms remain unclear.

AIM

To investigate the therapeutic effect and mechanism of modified PD in IM.

METHODS

This study used an IM mouse model established using 5-fluorouracil injections to investigate the effects of the modified PD (3, 6, and 12 g/kg) in IM. The primary chemical components of the modified PD were identified using liquid chromatography-mass spectrometry. Body weight loss, diarrhea scores, intestinal length, histopathological scores, and inflammatory cytokine levels were measured to evaluate the effects of the modified PD in IM. Effects on the TLR4/MyD88/NF-κB pathway were evaluated using western blot analysis. The intestinal microbiota was characterized using Illumina NovaSeq sequencing.

RESULTS

The results showed that modified PD significantly improved weight loss and diarrhea and shortened the intestines in IM mice. Mechanistically, modified PD suppressed the TLR4/MyD88/NF-κB pathway and downregulated the expression of reactive oxygen species, lipopolysaccharides, and pro-inflammatory cytokines (IL-1β, TNF-α, IFN-γ, IL-6, IL-8, and IL-17), while increasing the expression of the anti-inflammatory cytokine IL-10. Furthermore, modified PD protected the intestinal mucosal barrier by increasing the expression of tight junction proteins (occludin-1, claudin-1, and ZO-1) and mucin-2. Finally, 16S rDNA sequencing revealed that modified PD improved intestinal dysbiosis.

CONCLUSION

Our research offers new insights into the potential mechanism of modified PD in alleviating IM and provides experimental evidence supporting its pharmaceutical application in clinical IM treatment.
Addressing functional constipation in children: A call for comprehensive and collaborative management
Authors: Pan Yan , Jiao Fu-Yong
Published: January 2025

Functional constipation (FC) is the most common gastrointestinal disorder in children, with a global prevalence of 14.4% based on Rome IV criteria. This editorial explores the multifactorial pathogenesis and diagnostic complexity of FC, emphasizing the importance of early and accurate diagnosis. Effective management of FC hinges on child-oriented toilet training and the use of osmotic laxatives, particularly polyethylene glycol. Emerging therapies, including probiotics, serotonin 5-HT4 receptor agonists, chloride channel activators, and herbal remedies, offer promising options but require further research. Lifestyle modifications, such as adequate fiber and fluid intake and physiotherapy, are crucial in supporting pharmacological treatments. For intractable cases, a multidisciplinary approach involving pediatric specialists, nutritionists, physiotherapists, and psychologists is essential. This comprehensive strategy aims to improve the quality of life for children with FC and their families through continuous research, education, and collaborative care.
Potential Of Aqueous Extracts From Weeds And Food Crops In Oil Palm Plantations As Bioherbicides
Authors: Handayani Susi , Kinata Andreani , Susilo Edi
Published: January 2025

Purpose: This study aims to test water extracts derived from weeds and plants in oil palm plantations on the germination of test plants. The extract was prepared from June to July 2024 in Arga Makmur, North Bengkulu Regency, and the bioassay test was conducted from July to August 2024 in Pematang Gubernur, Muara Bangkahulu, Bengkulu City. Methodology: The study used a single-factor, completely randomized design. Twenty-one treatments were applied, namely, the source of extracts from broadleaf weeds, grass weeds, and teki weeds of 5 types each, as well as the control. The experimental unit was a Petri dish, and the experiment was repeated four times. The petri dish bioassay method was applied in this experiment. Each petri dish was given 10 mL of water extract, and 25 mung bean seeds of the Vima 2 variety were planted and incubated for three days. Results: The results showed that water extracts derived from weeds and plants in oil palm plantations significantly affected almost all variables. Findings: Water extracts that inhibit the germination of the highest test plants come from broadleaf weeds, namely Ageratum conyzoides, Chromolaena odorata, Stenochlaena palustris, Wedelia trilobata, and Amaranthus sp. Food crop groups are Oryza sativa, Manihot esculenta, Ipomoea batatas, and Vigna radiata. Grass weeds were Leersia hexandra and Eleusine indica, and no weeds were in the weed class. Novelty: This study provides insight into the potential of allelopathy sourced from weeds and food crops. Originality: This study offers a detailed analysis of the bioherbicidal effects of weed and food crop extracts on seed germination or test plants. Conclusion: Aqueous extracts of broadleaf weeds dominated the inhibition of seed germination and have great potential as bioherbicides. Document type: empirical research article.
 
Keywords: weeds; oil palm plantations; extract sources; food crops; bioherbicides
Systematic Analysis of Decentralized Finance
Authors: Szrajber Bentzion , Alon Ilan , Levy Shalom
Published: January 2025

The purpose of this article is to study analysis the Decentralized Finance (DeFi) literature. By synthesizing the themes and theorical frameworks, we aim to identify knowledge gaps and potential areas for future research in the DeFi landscape. We conduct bibliometric and content analysis on a corpus of 275 articles extracted from the Web of Science and Scopus databases. We use the Bibliometrix package in R software to apply co-citation and bibliographic coupling. We find three research clusters (a) socioeconomic (b) technology and (c) financial with their conceptual structure, interactions and transformations. Applying both co-citation and bibliographic coupling network analysis yields a dynamic view of the field tracing thematic evolution from its inception to the present day, revealing a decline in academic interest in DeFi security vulnerabilities in contrast to the growing emphasis on social media's influence on DeFi prices.
Nü Jidu in Matthew 24:27: An exegetical evaluation of Dongfang Shandian in China
Authors: Laia Harman Z. , Sutrisno Jimmy
Published: January 2025

This study examined the text of Matthew 24:27 using the exegetical method, which included textual, contextual, grammatical-structural, lexical and theological analysis. The purpose of this research was to evaluate and critique the interpretation put forth by the Eastern Lightning group, which claims that Christ has returned to the world as a Chinese woman through a second incarnation based on this text. However, the analysis revealed that the verse does not prophesy Christ’s second coming; rather, it depicts the nature of that coming, likening it to lightning flashing from the east to the west. This coming will be public, universal, clear, evident and witnessed by all humanity. Christ’s return has not yet occurred, but it will happen at the end of time, preceded by various terrifying events around the world known as the tribulation. Christ will return in his male form, as he ascended to heaven, not as a woman, and in his glory as King, not in the humble state of a human, to judge all humanity living on earth.Contribution: This study contributes to the discourse on Christology and eschatology by critically examining a modern theological movement in light of traditional interpretations of Scripture, providing clarity and insight into the nature of Christ’s return as articulated in the New Testament.
Perceptions of black employees regarding the psychological contract within an African context
Authors: Mahadulula Lutendo B. , Holtzhausen Maggie
Published: January 2025

Orientation: There is a need for researchers to investigate the constructs of psychological contract, work engagement and turnover intention within the context of the African knowledge system (AKS).Research purpose: The objective of this article is to expand knowledge on how African black employees perceive and experience their psychological contract, work engagement and turnover intention. The article explains how these perceptions and lived experiences are influenced by the race and culture of African blacks.Motivation for the study: Although the constructs of relevance are continually studied, not enough emphasis is placed on the given constructs from an AKS perspective.Research approach/design and method: An explorative, qualitative, interpretive phenomenological research approach with open-ended interviews for data collection was implemented. A non-probability and purposeful sampling (N = 16) strategy was followed. Thematic analysis was used to analyse the data.Main findings: African black employees’ perceptions and experiences regarding the psychological contract, work engagement and turnover intention are influenced by their race, culture and traditions (e.g. the spirit of ubuntu, weddings, traditional callings, funerals and church customs).Practical/managerial implications: African indigenous knowledge consciousness and diversity appreciation should be developed to ensure the effective implementation of human resources strategies and policies.Contribution/value-add: A unifying organisational culture and diversity management strategy that considers the needs of African black employees should be cultivated.
Comparative Analysis of Dentin Replacement Materials and Enamel Layer Thickness on Color and Translucency of Single-shade Composite Restorations
Authors: Anjum Syed Saliha , Muthalagu Mathuraivalan , Paul Princy , Padmanabhan Prabeesh , Rahul S. , Gokulapriyan Karuppiah
Published: January 2025

Objective:

To evaluate the color and translucency of the single-shade composite, Omnichroma (Tokuyama), when used as an enamel layer over aesthetically unfavorable dentin replacement materials, such as Biodentine (Septodont) and TheraCal LC (Bisco).

Materials and Methods:

Cylindrical dentin specimens (n = 8) were prepared using polyethylene molds (2 mm thick and 8 mm diameter). Specimens were capped with either a 1.5 or 2 mm thick layer of Omnichroma composite over 2 mm thick Biodentine or TheraCal LC. Color difference (ΔE) and translucency parameters were assessed using a spectrophotometer. Statistical analysis included analysis of variance and Tukey’s post hoc tests.

Results:

Both dentin replacement materials and enamel layer thickness significantly influenced the color and translucency of the restorations. Omnichroma effectively masked underlying materials when used in sufficient thickness, providing clinically acceptable aesthetics.

Conclusion:

Dentin replacement material and composite thickness affect the final color and translucency. A 2-mm thick layer of Omnichroma was effective in masking the underlying materials, ensuring desirable aesthetic outcomes.
Constraints in Dental Services Utilization Among the Dental Hospital of Jodhpur Region in Rajasthan, India
Authors: Chauhan Minal , Chand Sachin , Khan Mohsin , Shaktawat Neha , Ali Shadab , Kavitake Ranjeet D.
Published: January 2025

Background:

There has been a lot of interest in understanding oral health care utilization behavior as it is important for the delivery of effective oral health care. Identifying the barriers to dental services is one of the basic steps to improving the public health.

Aim:

We aimed to determine the barriers affecting the utilization of dental services in dental institutes.

Materials and Methods:

A cross-sectional survey was conducted among the patients attending the outpatient department of dental institute during the year 2023 among the 364 subjects and the data were collected using a specially designed and pretested questionnaire. The data were analyzed by descriptive and inferential statistics with the help of Statistical Package for Social Sciences version 22.0.

Results:

It was seen that the majority of the participants agreed that cost (55%) was identified as the most imperative factor affecting dental services followed by the dentist-patient relationship at a statistically significant level (P = 0.0001).

Conclusion:

The foremost barriers to dental care utilization were cost, fear, and organization. However, the policies should be fair and impartial as policymakers, administrators, and insurance organizations play a key role in the health care system.
Analyzing the Effects of HPV Vaccination Programs on the Incidence of Oral Cancers and Other Related Pathologies
Authors: Singh Jyotsna , Shivam Animesh Kr
Published: January 2025

Objective:

To investigate the impact of human papillomavirus (HPV) vaccination programs on the incidence of oral cancers and other related pathologies.

Materials and Methods:

A cross-sectional study was conducted with a sample size of 500 participants aged 18–35 years, recruited from urban and rural healthcare centers. Data were collected through questionnaires and medical records, analyzing the incidence of oral cancers and other pathologies in vaccinated versus nonvaccinated individuals. Statistical analysis was performed using chi-square tests and logistic regression models.

Results:

The study found a significant reduction in the incidence of oral cancers and other related pathologies among vaccinated individuals compared with nonvaccinated individuals (P < 0.05). Specifically, the incidence of HPV-positive oropharyngeal cancers was notably lower in the vaccinated group than in the nonvaccinated group. Logistic regression analysis confirmed that vaccination was a significant protective factor against developing oral cancers (odds ratio = 0.45, 95% confidence interval = 0.30–0.68).

Conclusion:

HPV vaccination programs are associated with a significant reduction in the incidence of oral cancers and related pathologies. These findings support the continued promotion and expansion of HPV vaccination programs as a public health strategy to prevent oral cancers.
Identification of patients with advanced pancreatic cancer who might benefit from third-line chemotherapy
Authors: Kim Bomi , Kim Jaihwan , Yang Soomin , Ahn Jinwoo , Jung Kwangrok , Lee Jong-Chan , Hwang Jin-Hyeok
Published: January 2025

BACKGROUND

Survival rates of patients with advanced pancreatic cancer (APC) have been improved with palliative chemotherapy series. The current preferred first-line regimen consists of combination therapy of 5-fluorouracil (5-FU)/leucovorin (LV), irinotecan, and oxaliplatin (FOLFIRINOX) or gemcitabine plus albumin-bound paclitaxel (GNP). After failure of first-line chemotherapy, there are a few options for subsequent therapy including switch to the unused first-line regimen or nano-liposomal irinotecan and 5-FU/LV. However, there are limited studies on the efficacy of third-line chemotherapy after failure of second-line chemotherapy.

AIM

To identify patients with APC who might benefit from third-line chemotherapy.

METHODS

Medical records from a single tertiary hospital were retrospectively reviewed between 2012 and 2021. The study included patients with histologically or cytologically confirmed metastatic or locally APC who underwent first-line FOLFIRINOX or GNP and subsequently received third-line chemotherapy. Overall survival (OS) after diagnosis and OS after third-line chemotherapy (OS3) were defined as the interval from the diagnosis to all-cause death and the time between the initiation of the third-line chemotherapy to all-cause death, respectively.

RESULTS

A total of 141 patients were enrolled. The median patient age at diagnosis was 61.8 years (36.0-86.0), and 54.9% were male. The first-line regimen was FOLFIRINOX (67.4%) or GNP (32.6%). The second-line regimen was FOLFIRINOX (27.0%), GNP (52.5%), or other (20.6%). The median OS was 19.0 months, and the median OS3 and progression-free survival after third-line treatment were 15.3 and 7.3 weeks, respectively. With regard to the best tumor response during third-line chemotherapy, 1.4% had partial response, 24.8% had stable disease, and 59.6% had progressive disease. The following clinical factors before third-line chemotherapy affected OS3: Good performance status (PS), serum carbohydrate antigen 19-9 (CA19-9) level < 1000 U/mL, duration of second-line chemotherapy ≥ 19 weeks, and no peritoneal seeding.

CONCLUSION

This study identified that patients with good PS, CA19-9 < 1000 U/mL, second-line chemotherapy ≥ 19 weeks, and no peritoneal seeding before starting third-line treatment may benefit more from third-line chemotherapy.
Prognostic value of inflammatory markers in predicting recurrence-free survival in gastrointestinal stromal tumor patients: A nomogram-based approach
Authors: Zhao Jin-Long , Wang Mao-Ying , Lv Yan-Zhi , Zhou Ye-Jiang
Published: January 2025

BACKGROUND

There are currently no relevant studies at home or abroad that combine inflammatory indicators and nomograms to predict the prognosis of gastrointestinal stromal tumor (GIST) patients after surgery. The purpose of this study was to investigate the predictive value of related inflammatory indicators [systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/Lymphocyte ratio (MLR)] in patients undergoing GIST surgery, incorporating relevant risk factors to establish a nomogram prediction model, with the aim of better predicting the prognosis of GIST patients.

AIM

To explore the relationships between the SII, NLR, PLR, and MLR and postoperative recurrence in patients with GIST.

METHODS

This study retrospectively included patients who underwent GIST surgery from January 2014 to January 2017 and analyzed the potential relationships between the preoperative SII, NLR, PLR, and MLR and clinicopathological features. The independent risk factors influencing the prognosis of GIST patients were obtained via multivariate regression analysis, and a nomogram model based on the independent risk factors was established.

RESULTS

Among the 124 GIST patients included in the present study, 31 (25%) experienced recurrence within 5 years. Kaplan-Meier survival analysis revealed a correlation between the MLR and PLR and tumor size (P = 0.016 and P = 0.002, respectively). The preoperative SII, MLR, NLR, and PLR were significantly associated with recurrence-free survival (RFS) (P < 0.05). The multivariate analysis results identified the PLR, MLR, and targeted therapy as independent prognostic factors for patient outcomes.

CONCLUSION

Preoperative MLR and PLR, which are independent risk factors for GIST recurrence, were correlated with RFS. Nomograms based on the PLR, MLR and targeted therapy can be used for clinical treatment.
Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors
Authors: He Yan-Fei , Wang Huan-Zhi , Hu Xiao-Dong , Liu Jun-Qiang , Li Hu-Ming , Wang Jie , Lu Shuang-Feng
Published: January 2025

BACKGROUND

Data on clinical characteristics, treatment outcomes, and prognosis of pancreatic primitive neuroectodermal tumors (PNETs) are limited.

AIM

To analyze the clinical data of 30 patients with pancreatic PNETs to identify their clinical characteristics and factors associated with prognosis.

METHODS

We used the keywords "primary neuroectodermal tumor," "digestive tract," "pancreas," "pancreatic," and "gastrointestinal," individually or in combination, to collect data from a global database for all patients with pancreatic PNET to date. Univariate and Cox regression analyses were performed to identify prognostic factors for patient survival.

RESULTS

A total of 30 cases of pancreatic PNET were included in this study: 15 males and 15 females with a mean age of 24 years. The main symptom was abdominal pain (73.3%), and the median tumor size was 7.85 cm. Twenty-four patients (80.0%) underwent surgery and nineteen patients received adjuvant therapy. Local metastasis was observed in 13 patients (43.3%), lymph node metastasis in 10 patients (33.3%), and distant metastasis in 6 patients (20.0%). Local recurrence was observed in 13 patients (43.3%). The median survival time of all patients was 29.4 months, and the overall estimated 1-year and 3-year survival rates were approximately 66.0% and 36.4%, respectively. Univariate analysis showed that chemotherapy (P = 0.036), local metastasis (P = 0.041), lymph node metastasis (P = 0.003), distant metastasis (P = 0.049), and surgical margins (P = 0.048) were the prognostic factors affecting survival. Multivariate analysis revealed only lymph node metastasis (P = 0.012) as a prognostic factor.

CONCLUSION

Pancreatic PNET is extremely rare, occurs in young adults, has no apparent sex predisposition, has a high rate of metastasis and early recurrence, and has a very poor prognosis. The diagnosis of pancreatic PNET requires a combination of clinical symptoms, pathologic features, immunohistochemistry, and cytogenetic analysis. Univariate analysis suggested that chemotherapy, metastasis, and surgical margins were prognostic factors affecting survival, and multivariate analysis suggested that lymph node metastasis is an important prognostic factor. Therefore, early diagnosis, early and extensive resection, and adjuvant chemoradiotherapy may help improve prognosis.
Metastatic lymph node distribution and pathology correlations in upper and lower gastric cancer patients: A multicenter retrospective study
Authors: Yuan Xian-Bei , Sun Gang , Niu Jun , Dong Lei , Sui Yi , Lv Yong-Zhu
Published: January 2025

BACKGROUND

Gastric cancer (GC) poses a significant threat to public health. However, the clinicopathological features and tumor biological behaviors vary among the GC patients, leading to individual variations in lymph node metastasis. Consequently, the stratification of lymph node dissection according to the specific type, particularly upper GC, has emerged as a prominent area of research.

AIM

To investigate the distribution of metastatic lymph nodes in patients with upper and lower GC and to analyze the differences in related pathological elements and prognosis.

METHODS

Differential analysis between upper and lower GC patients with various clinicopathological factors was performed using the chi-square test and rank-sum test. Logistic regression models were used to identify risk factors for GC lymph node metastasis, while Cox regression models were used to analyze risk factors affecting patient prognosis. The Kaplan-Meier method was used to construct survival curves associated with prognostic risk factors for GC.

RESULTS

Significant differences were observed between the two GC populations regarding tumor diameter, histological grade, pT stage, pN stage, tumor-node-metastasis (pTNM) stage, vascular invasion, and adjuvant chemotherapy usage (all P < 0.05). Lymph node metastasis rates were highest for Siewert type II patients in groups Nos. 1, 3, 2 and 7; for Siewert type III patients in groups Nos. 3, 1, 2 and 7; and for other/unclassified patients in groups Nos. 1, 3, 7, 2. In the lower GC samples, the sequences were Nos. 3, 6, 7, 4. Pathological type, pT stage, pTNM stage, and positive vascular invasion were independent risk factors for development of lymph node metastasis. Age, pathological type, pT stage, pN stage, pTNM stage, vascular invasion, and absence of adjuvant chemotherapy were identified as independent prognostic factors.

CONCLUSION

Upper GC showed a significantly higher malignancy grade and different lymph node metastasis pattern than lower GC.
Innovative applications and research progress of hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma
Authors: Yang Ting-Fang , Kong Mo-Wei
Published: January 2025

This article provides an in-depth analysis of the study conducted by Wang et al , which explores hepatic arterial infusion chemotherapy and its synergistic strategies in managing advanced hepatocellular carcinoma (HCC). HCC ranks as the fourth most common cause of cancer-related mortality globally and is frequently associated with portal vein tumor thrombus (PVTT). The approach to managing HCC, particularly when PVTT is present, diverges markedly between Eastern and Western practices. These differences are rooted in variations in epidemiology, etiology, pathology, comorbidities, and prognosis. The paper delves into the diagnosis, classification, and treatment strategies for HCC with PVTT, as well as the evolving role and advancements of hepatic arterial infusion chemotherapy in the therapeutic landscape of HCC.
Hepatic artery infusion chemotherapy: A resurgence
Authors: Fung Andrew Kai-Yip , Chok Kenneth Siu Ho
Published: January 2025

In this manuscript, we comment on the article by Zhou et al , who assessed the efficacy of hepatic arterial infusion chemotherapy (HAIC) and its combination strategies for advanced hepatocellular carcinoma (HCC) using network meta-analysis methodology. We focus specifically on the potential advantages and role of HAIC in the treatment algorithm for advanced HCC. However, there remains numerous knowledge gaps before the role of HAIC can be established. There is significant heterogeneity of HAIC regimes with difficult interpretation of the clinical outcomes. Additionally, there is a lack of direct comparative data between HAIC, systemic chemotherapy, novel immunotherapies and targeted therapies. The underlying biochemical mechanisms that might explain the efficacy of HAIC and its effect on the HCC microenvironment requires further research. In the developing era of nanotechnology and targeted drug delivery systems, there is potential for integration of HAIC with novel technologies to effectively treat advanced HCC whilst minimising systemic complications.
OPTIMIZING HEART HEALTH THROUGH AYURVEDA: A DETAILED FOCUS ON
THE PREVENTION AND TREATMENT OF HRIDROGA
Authors: Rajpurohit Ranu , joshi Gulshan , Kumar srivastava Akhilesh , Angmo Dichen
Published: January 2025

Purpose(Introduction): Diseases associated with a person's lifestyle are known as lifestyle diseases. Condi-tions, including heart disease, stroke, obesity, and type II diabetes, mainly impact our way of life. This article focuses on the idea of Hridroga (Heart Diseases) and how to handle it from an Ayurvedic perspective, including current updates so that one might avoid certain illnesses or treat them with greater precision.
Design/methodology/approach: The study is grounded in analysing ancient Ayurvedic texts, including the Charaka Samhita and Sushruta Samhita. It examines the concepts of Dosha Imbalances, dietary guidelines, and holistic practices prescribed for maintaining heart health.
Discussion :
Heart disease, or Hridroga , is one of the leading causes of death in India. In Ayurveda, heart disorders are re-ferred to as Hridroga. The heart is a Marma, or vital organ.
Cardiovascular disease is one illness that is significantly on the rise in the modern day. Stress, alcohol consump-tion, smoking, and high-calorie intake are a few examples of lifestyle modifications that raise the risk of cardio-vascular disease. Nidan-Parivarjana (avoid causative factor) is the first line of treatment for all ailments since Nidan(Causative Factor) plays a significant role in how disorders emerge.

Practical implications: The Ayurvedic scriptures provide in-depth explanations of the causes, signs, and treat-ment of Hridroga. Ayurveda describes in great detail how vitiated Pitta, Kapha, and Vata cause symptoms and how to treat them clinically to avoid these circumstances.
Originality/value: This study, which focuses primarily on cardiac ailments, aids in managing lifestyle condi-tions.
REVITALIZING THE MIND: MEDHYA RASAYANA’S HOLISTIC INFLUENCE ON MENTAL WELLNESS.
Authors: - Pratibha , Singh Randhir
Published: January 2025

Ayurveda’s holistic approach to mental health, mainly through Medhya Rasayana, offers a comprehensive framework for enhancing cognitive and emotional well-being. Medhya Rasayana encompasses a range of rejuvenating
herbs like Brahmi and Shankhapushpi described under Chikitsa Sthana of Charaka Samhita. Their description at
the beginning of Chikitsa Sthana shows how important they are. They play a crucial role in supporting cognitive
functions, improving memory, and alleviating symptoms of mental disorders. Mental health is deeply intertwined
with physical health, lifestyle choices, and environmental influences. Medhya Rasayana uses are customised according to individual Prakriti and current Dosha Vikriti, ensuring that each treatment aligns with the unique needs
of the person. By focusing on root causes rather than just alleviating symptoms, Ayurveda provides a multifaceted
approach to mental health that encourages long-term wellness, self-discovery, and harmony in life.
INDUCTION AND AUGMENTATION OF LABOUR IN AYURVEDA – A REVIEW
Authors: H.Phirke Neha , G.Jangale Ketan
Published: January 2025

Childbirth is a natural process. Early delivery without complications and the need for a Cesarean section is the
dream of every pregnant woman and her family. But sometimes, labour pains may not progress well and cause
impatience among women due to delayed labour. Oxytocin and prostaglandins are used in practice for induction of
labour (IOL), but it may cause uterine overstimulation, and hence, in that case, the C-section is prioritized. Acharya
Sushruta, Vagabhatt, Yogaratnakar, and Bhavaprakasha have prescribed certain drugs for the treatment of “delay
in labour”. Vitiated Vayu is said to be a cause for delay in labour, and drugs prescribed work effectively on Vayu.
ROLE OF UPASHAYA IN THE MANAGEMENT OF VIPADIKA KUSHTHA – A CASE REPORT
Authors: Mantur Sudha , Kumar Shetty Ranjith , K.A Sri Nagesh
Published: January 2025

Upashaya refers to an "Aushadhadijanitasukhanubandhaupashaya" that brings in the comfort, relaxation, and relief of symptoms through Aushadha, Ahara and Vihara. It can be considered a symptomatic treatment, actual treatment, and diagnostic tool. In today's context, utilising Upashaya is crucial for guiding the appropriate treat-ment plan, especially in specific disease-related conditions. Upashaya is classified into two main types: Viparee-ta and Vipareetaarthakari. Among these, Vipareeta Upashaya is the most commonly referenced and practiced; Ubhaya Vipareeta Aushadha is one among the Vipareeta Upashaya, which means Medicines that act as both the cause of the disease and the disease itself. To highlight its role in Upashaya, it is necessary to analyse this con-cept with the intention of practically validating it, for which Vipadika kushta has been taken up for the study. Vipadika kushta is one of the Kshudra Kushta. It is Vata Kaphaja Vyadhi, which is characterised by Sphu-tana(Fissure)either in Pani (palm) or Pada(soles) or both with Teevra Vedana (severe pain). Based on the sources, the incidence rate is 3–4%, but it is one of the major cosmetic issues as well as a hurdle for carrying out routine work. This is the case report of the successful management of Vipadika Kushtha with a single formula-tion, Tila kusumadi Lepa—a 35-year-old male patient who presented with a complaint of Cracks on both feet with severe pain. The patient was given Ayurveda treatment for 15 days. After follow-up, significant improve-ment was observed in signs and symptoms. The present case highlights the potential of a single formulation in managing Vipadika Kushtha.
MANAGEMENT OF JANU SANDHIGATAVATA W.S.R. O.A. KNEE JOINT: A CASE STUDY
Authors: Parmar Swati
Published: January 2025

Osteoarthritis of the knee joint is the leading cause of chronic disability worldwide. Acharya Charaka described
the disease separately, named “Sandhigata Anila”, under the heading of Vatavyadhi. Vagbhata has considered
Vatavyadhi as Maharoga. To date, Sandhivata is a challenging disease and is the number one cause of disability
in old age. Sandhivata is a disease occurring due to the affliction of sandhis by vitiating Vata dosha. For vata
vikara bahya prayoga (external application) of oil is indicated. Different oil formulations have different modes of
action. Saindhavadi Taila is one such formulation. The treatment concept focuses on relieving symptoms and
maintaining and improving joint functions. The present article deals with the case of a patient with pain in both
knee joints. Difficulty in walking and standing back after long sitting. Janu basti with Saindhavadi Taila was given to this patient.
TREATMENT OF VATASHTHILA (BENIGN PROSTATIC HYPERPLASIA) THROUGH AYURVEDIC MEDICINES- A CASE REPORT
Authors: Sharma Sukriti , Prajapati Munnalal , Singh Jaram , Sason Rajveer
Published: January 2025

Background: A prevalent issue affecting older men is Benign Prostatic Hyperplasia. Even though prostatectomy
is the most effective course of action, conservative management is always favoured. Ayurvedic medicines can
help such folks live better lives and relieve their symptoms. In Ayurvedic Samhitas, urinary disorders are mentioned as Mutraghata (Suppression or obstruction of urinary flow). The words Mutra (which refers to urine) and
Aghata (which denotes obstruction of the urinary passage) are combined to form the term Mutraghata. Vatashthila is one of the types of Mutraghata. The symptoms of BPH are similar to those of Vatashthila caused by an imbalance of Vata Dosha. In this case study, we demonstrate how Ayurvedic medicines reduced the size of the prostate and the International Prostatic Symptoms Score. Main Clinical Findings: A 65-year-old patient reached the
hospital with a complaint of intermittent pain in the suprapubic region and frequent micturition. He disclosed further lower urinary tract symptoms (LUTS), including urgency, dysuria, and nocturia (more than four urinations in
the night). Conclusion: BPH is an age-linked disease. Even though surgery is the most effective form of treatment, using Ayurvedic medicines may help to lessen the symptoms and improve overall quality of life. After taking Ayurvedic treatment, the patient was relieved from symptoms, and the prostate became normal in size.
MANAGEMENT OF TRAUMATIC QUADRIPARESIS (ABHIGHĀTAJA SARVĀṄGA
VĀTA) WITH PAÑCAKARMA THERAPIES - A CASE STUDY
Authors: Nalini K.V. , Prasad V. Lakshmana
Published: January 2025

Globally, 15 million people are living with spinal injuries. Spinal injury Percentage of total Neurological
disorders disease burden in India is 1.9.The following is a case managed in Dept of Pañchakarma, S.V. Ayurvedic Hospital, Tirupati, depicting the success of various Pañchakarma therapies. A 65-year-old male patient with a
chief complaint of loss of sensations from below the neck and weakness in both upper and lower limbs, giving the
history of a road traffic accident in the year 2015 and underwent Microscopic anterior cervical C3 - C4 discectomy and fusion surgery after the accident. He has been treated with Sarvāṅga Abhyaṅga and Nāḍī swedam for 3
days, Mātrāvasti with Nirguṇḍītailam for 7 days, Kālavasti with Vājigandhādiyoga for Āsthāpana and Nirguṇḍī
tailam for Anuvāsana for 16 days. The ASIA scale score recorded at the outset was 78/324, Which improved to
205/324 after the completion of therapies. The patient ultimately regained his sensations and had moderate improvement in motor power of muscles, which was reflected in the ASIA scale. Sarvāṅga Abhyaṅga and Nāḍī
swedam administered initially have been considered as the first-line therapies in the management of vitiated Vāta.
The Mātrāvasti administered afterwards has tremendous Vātahara property. The Vājigandhādi yoga, which has
been explained in Vaṅgasena for the management of Gṛdhrasīvāta, is tried here in Kālavasti format. The abovestated Pañchakarma therapies have shown significant amelioration in both sensory and motor deficits. More over
they proved safe during the entire length of course.
A Review on Integrating Smart Aquifer Recharge Systems into Urban Road Networks: A Sustainable Approach to Water Management and Urban Resilience
Authors: M. Mahadeva , V. Bhavya , M. Gowda Nidhishree , A. Angadi Siddanna , Farooq Arsalaan
Published: January 2025

This literature review examines the integration of Smart Aquifer Recharge Systems (SARS) into urban road networks to address groundwater depletion, urban flooding, and water scarcity. The SARS approach involves innovative techniques such as collecting runoff water from roads using perforated medians and corner drainage systems and directing it through sedimentation tanks for pre-treatment before infiltration. Studies highlight the significance of managing stormwater in urban areas, where impervious surfaces limit natural recharge, contributing to the decline of flooding and the water table decline. Key findings reveal the potential of advanced filtration systems, permeable pavements, and GIS-based site selection to enhance recharge efficiency. Challenges such as maintenance, space constraints in urban areas, and irregular rainfall patterns are also discussed. Existing research underscores the need for real-time monitoring and adaptive management to optimize recharge efforts. This review identifies gaps in long-term system performance and scalability in high-density urban regions. By focusing on integrating SARS into road infrastructure, the study aims to contribute to sustainable urban water management and align with global sustainability goals. The findings are a foundation for implementing cost-effective and innovative solutions in cities like Bangalore, addressing critical water challenges while improving urban resilience.