bluuebunny/crossref_metadata_2025 huggingface dataset:
Tenofovir vs. Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma after Radiofrequency Ablation
Authors: Hu Zili , Zeng Huilan , Hou Jingyu , Wang Juncheng , Xu Li , Zhang Yaojun , Chen Minshan , Zhou Zhongguo
Published: March 2022

For patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) treated with curative radiofrequency ablation (RFA), the effect of entecavir (ETV) vs. tenofovir disoproxil fumarate (TDF) on recurrence-free survival (RFS) and overall survival (OS) remains unclear. We aimed to compare the outcomes of patients receiving ETV or TDF after RFA. This study consecutively collected patients who were treated with ETV (n = 202) or TDF (n = 102) for chronic hepatitis B (CHB) after curative RFA of HCC from December 2015 to January 2021 at Sun Yat-sen University Cancer Center. There were 130 patients in the ETV group and 77 patients in the TDF group after we performed 1-to-n propensity score matching. Kaplan–Meier and Cox regression analyses were performed to validate possible risk factors for RFS and OS. In addition, we estimated the curative effect of ETV and TDF for HBV-related hepatitis by recording the change in serum HBV DNA and ALBI grade after RFA. During the study period (median 34.1 (interquartile range: 19.6–47.4 months) months), 123 (40.5%) patients suffered HCC recurrence, and 15 (4.9%) died. In the full cohort, the probability of HCC recurrence (41.6% vs. 37.3%, p = 0.49) and overall survival (95% vs. 95.1%, p = 0.39) at 5 years were similar between the ETV and TDF groups. In the matched cohort, HCC recurrence (40.8% vs. 40.3%, p = 0.35) and overall survival (96.9% vs. 93.5%, p = 0.12) at 5 years were similar between the ETV and TDF groups. Furthermore, the early RFS (<2 years) did not differ significantly between the two groups in the full and matched cohorts (p = 0.26, p = 0.13). Compared with the ALBI grade before RFA, the ALBI grade of 80 patients (41%) remained stable or improved in the ETV group and 64 patients (64%) in the TDF group (p < 0.001). The mean time of serum HBV DNA reduction to 0 was 9.13 (95% CI: 5.92–12.33) and 2.75 (95% CI: 2.01–3.49) months in the ETV and TDF groups, respectively (p = 0.015). The RFS and OS of patients after curative RFA for HCC were not significantly different between the ETV and TDF groups. TDF therapy was associated with a better effect of protecting liver function and reducing the load of HBV. Further validation studies are needed.
Editorial: Adaptation to Coastal Climate Change and Sea-Level Rise
Authors: Reguero Borja G. , Griggs Gary
Published: March 2022

Climate change is already affecting many weather and climate extremes in every inhabited region across the globe [...]
Transport Behavior of RB5 Dye in Alluvial Soil in the Northeast of Brazil
Authors: Alves Adriana Thays Araújo , Coutinho Artur Paiva , de Oliveira Barros Vitor Hugo , Lassabatere Laurent , dos Santos Neto Severino Martins , de Sousa Lima José Romualdo , Antonino Antonio Celso Dantas
Published: March 2022

The textile industry generates a large volume of chemically diversified effluents containing, among other compounds, dyes. Untreated wastes are contaminants to surface water, soil, and groundwater. In this aspect, various studies have explored the issue of contamination of alluvial soils in the Alto Capibaribe region, northeast of Brazil, due to local textile activity. This region, inserted into the Brazilian semiarid region, suffers from water scarcity, and there is a need for rural communities to use alluvial formations for water supply. The simulation of solute transport is a fundamental tool for understanding the environmental performance and risks associated with contamination by textile dyes. Transport parameters that directly influence pollutant dynamics in sedimentary environments are characterized. This study evaluated the retention and mobility of the dye Remazol Black 5 (RB5) in two superficial layers of alluvial soil from Alto Capibaribe to obtain transport parameters. In the laboratory, tests of mobility in soil columns with RB5 dye (concentration of the 25 mg L−1) and KBr tracer (concentration of the 35.7 g L−1) solutions were conducted. The CDE and two-region models were used to model the KBr experimental transport data, and the two-site model was used to model the RB5 experimental transport data. Physical non-equilibrium was found in the soils for KBr transport, and the two-region model adequately modeled the experimental breakthrough curves (BTCs). For the transport of RB5, the results showed a chemical non-equilibrium, and the two-site model was adequate to model the experimental BTCs. The results indicate that the surface layer is most responsible for the retention of RB5, where the RB5 solution was less mobile than in the lower layer. Both layers showed low retention and high mobility for RB5, indicating that the RB5 dye in the region may contaminate groundwater.
Water Procurement Time and Its Implications for Household Water Demand—Insights from a Water Diary Study in Five Informal Settlements of Pune, India
Authors: Zozmann Heinrich , Klassert Christian , Klauer Bernd , Gawel Erik
Published: March 2022

Many private households spend considerable amounts of time accessing water, for instance by walking to and queuing at public access points, or by filling storage vessels at taps with low flow rates. This time has an opportunity cost, which can be substantial and may impact which water services and quantities of water households demand. In a novel form of diary study, we gathered detailed water consumption and time use data from 50 households in five informal settlements of the Indian metropolis Pune, accompanied by a household survey and in-depth interviews. With the data, we characterize water collection behaviors and assign monetary values to water procurement time. We statistically analyze the effects of time cost on consumed quantities in several two-level mixed-effect models. Household members in our sample spend up to several hours each day filling storage vessels, even if a private connection to the piped network is available. Average time cost amounted to the equivalent of 4.23–13.81% of monthly household cash income. Our analyses indicate that procurement time reduces quantitative water demand in a significant way. The households incurring the highest per-unit time cost consumed water quantities below minimum levels recommended for human health. This substantiates that time costs can impede access to water and are a relevant issue for water management and policy.
Novel Fluorinated Nitrogen-Rich Porous Organic Polymer for Efficient Removal of Perfluorooctanoic Acid from Water
Authors: Liu Gaoxi , Wei Xiaohui , Luo Peiru , Dai Shuyu , Zhang Wenfen , Zhang Yanhao
Published: March 2022

The mobility, durability, and widespread use of perfluorinated and polyfluoroalkyl substances (PFAS), notably perfluorooctanoic acid (PFOA), bring about serious contamination of many ground and surface waters. In this study, fluorine and amine-functionalized porous organic polymer (POP-4F) was designed and successfully synthesized as an adsorbent for PFOA removal in water. The characterization results showed that the synthesized material had an amorphous microporous structure, and the BET surface area was up to 479 m2 g−1. Its versatile adsorption property was evaluated by batch adsorption experiments using PFOA as a probe. The experiments show that the polymer was able to remove 98% of the PFOA in 5 min from water and then desorb within 3 min in methanol ([PFOA]0 = 1 mg L−1; [POP-4F] = 200 mg L−1). Specifically, the adsorption capacity of POP-4F is up to 107 mg g−1, according to the Langmuir fit. The rapid adsorption and desorption of PFOA by POP-4F offers the possibility of economical, environmentally friendly, and efficient treatment of real wastewater.
Racial Discrimination against Minority Healthcare Workers in Women’s Health
Authors: Khan Khalid S.
Published: March 2022

The women’s sexual and reproductive healthcare sector, one of the largest employers delivering services globally, does not always commit to equality, diversity, and inclusion. There is objective, published evidence that not only care provision but also workforce treatment permits inequality and discrimination. The black and ethnic minority workforce in the women’s health specialty, compared to their white counterparts, is often treated unfavorably in appointments, is less often afforded academic development opportunities, is, at many sites, subjected to disproportionately greater disciplinary penalties, tends not have representation in positions of authority, and undertakes training in what is often perceived as a climate of fear due to racism. This problem deserves immediate action by professional bodies. They have the responsibility to remove feelings of exclusion and lack of belonging to all staff, the negative impact on wellbeing caused by unnecessary stress, and concerns over career progression among minority ethnic healthcare workforce and other workers who report discrimination. This duty is part of the societal responsibility to ensure fairness and eradicate discrimination under the equality, diversity and inclusion agenda.
Modern requirements for and regulation of medical activities in the field of recreation and rehabilitation of children and adolescents
Authors:   Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of the Russian Federation, Federal State Budgetary Educational Institution International Children's Center «Artek», Koptseva Anna Valerievna , Letifov Gadzhi Mutalibovich ,   ederal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of the Russian Federation
Published: March 2022

The organization of medical care in the field of recreation and rehabilitation of children and adolescents is carried out on the basis of regulatory legal documents and features of functioning of a health institution. The paper analyzes the current regulatory legal acts and sanitary requirements and substantiates the need for their improvement, taking into account the changing tasks in the system of protecting children's health. The need to set out the requirements for medical activities of educational centers of international and all-Russian level in the form of a separate section of the procedure for providing medical care to minors during the period of recovery and organized recreation was noted. Taking into account the peculiarities of the educational regimen, diet and physical activity of children in the Centers, as well as the possibility to provide emergency medical care of appropriate volume and quality, it is proposed to consider the inclusion of the following diseases in the list of contraindications: diabetes mellitus, phenylketonuria, severe forms of allergic diseases, fermentopathies requiring an individual approach to the organization of nutrition, motor disorders with the impossibility of self-care, systemic connective tissue diseases, blood diseases requiring dynamic control and having a high risk of complications, heart rhythm disturbances with a risk of developing life-threatening conditions.
Clinical and diagnostic features of occupational polyneuropathy in combination with damage to the locomotor apparatus in workers of harmful professions
Authors:   FBSI Ufa Research Institute of Occupational Medicine and Human Ecology, 94, Stepana Kuvykina str., Ufa, Republic of Bashkortostan, a Gallyamova Svetlana Anifovna , Shaykhlislamova Elmira Radikovna ,   FBSI Ufa Research Institute of Occupational Medicine and Human Ecology,  FSBEI HE Bashkir State Medical University of the Ministry of Health of Russia, Gareeva Liliya Fillurovna ,   FBSI Ufa Research Institute of Occupational Medicine and Human Ecology, Volgareva Alfiya Dinislamovna ,   FBSI Ufa Research Institute of Occupational Medicine and Human Ecology
Published: March 2022

An urgent task for the occupational pathology service of the country is the search for objective methods for the early diagnosis of occupational diseases of the peripheral nervous system, in combination with the pathology of the musculoskeletal system, often occurring among workers of hazardous industries. Based on the analysis of electroneuromyographic and radiological research methods in 60 workers performing work with the impact of local vibration and physical overload, the degree of impairment of the peripheral nervous system and the musculoskeletal system of the upper limbs was studied in comparison with persons whose labor activity excluded contact with these labor factors. A relationship has been established between the severity of clinical and instrumental data obtained with the duration of exposure to harmful factors. Identification of lesions of the peripheral nervous system and the locomotor apparatus will ensure timely prevention and adequate therapeutic measures.
A Survey of Covid-19 Deaths Among American Clergy
Authors: Dixon J.M.
Published: March 2022

This research aims to discover the number of clergy deaths in the United States that resulted from complications associated with coronavirus disease 2019 (Covid-19). The FaithX Project, in association with researchers from the Global Center for Religious Research (GCRR), conducted a survey of sixteen major Christian denominations in the United States. The methodology for this study was to contact leaders in these denominations (via email and phone) who oversaw specific church judicatories. The research took place from January to June of 2021. There was an average response rate of 23.12% across the sixteen Christian denominations contacted. 169 judicatories responded to the survey and a total of 118 clergy deaths were reported, with the Catholic Church recording the most: 43 deaths. The average overall death rate for these denominations was 0.23%, with the highest rate being the Catholic Church at 0.73%. Utilizing this information, it can be estimated that somewhere between 1,008 and 1,099 total clergy in the United States died from Covid-19.
Социокультурный облик эскимосов острова Врангеля в 1930-1940-х гг.
Authors:   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan, Khakhovskaya L. N.
Published: March 2022

The dynamics of the ethnic and social appearance of the indigenous population of Wrangel island in the 1930-1940s is traced. Changes in environmental management, material culture, and social organization are analyzed. The nature and results of external influence on the aboriginal community are discussed. Social changes within a closed indigenous community with weakened external support, exemplified by the island population, are considered negative. Dependency trends in everyday life and nature management spread among the islanders. This social shift caused uneven distribution of work efforts for survival among capable community members. The asymmetry of the work load resulted in the weakening of internal ties and to the division of the ethnic community into individual households.
Флюоритоносность Северо-Востока России
Authors:   Yu. A. Kosygin Institute of Tectonics and Geophysics, FEB RAS, Khabarovsk, Cherepanov A. A. , Berdnikov N. V. ,   Yu. A. Kosygin Institute of Tectonics and Geophysics, FEB RAS, Khabarovsk
Published: March 2022

One deposit and 217 occurrences of fluorite, grouped in the fluorite, the rare-metal-fluorite, and the polymetal-fluorite mineral formations, are known in RussiaТs North-East. Occurrences of fluorite formations are most widespread, while the stratiform occurrences in the Urultun-Taskan zone at the Omulevskoye uplift are especially rich in resources. Fluorite occurrences themselves are widespread within the Okhotsk-Chukotka volcanogenic belt. Fluorite-bearing belts, areas, and zones are distinguished. Fluorite minerogenic resources of RussiaТs North-East are estimated.
О возможной природе сталактитоподобных образований в агатах Ольского плато (Северо-Восток России)
Authors:   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan, Savva N. E.
Published: March 2022

The features of the stalactite-like formations relationship with onyxes in the geodes of the Ola basalt plateau agates are considered. It is shown that such formations are formed from the gel in the arc parts of cavities and flow down in the shape of icicles under the influence of gravity. "Stalactites" intersect previously formed layers of opal, chalcedony, quartz. The onyx layers. consisting of the silica group (SiO2,) minerals, can be dissolved only with the participation of F or HF. This is especially important in the case of poured basalts, since they contain no silica (SiO2) minerals, and silicon crystallizes in a different coordination (SiO4, Si3O8) in feldspars, olivine, etc. Geode filling with silica can be explained by the passage of gaseous HF and F from volcanic emanations through the thickness of silicon-containing rocks, with partial Si dissolution and formation of gaseous silicon tetrafluoride (SiF4), which fills cavities (bubbles) in basalt lavas. Subsequently, when meteoric water seeps into the cavity, silicon tetrafluoride is hydrolyzed to form orthosilicic acid, which is transformed into silica gel; the latter polymerizes to form chalcedony. Simultaneously, the remains of F either evaporate through cracks or accumulate in the cavity arch, again dissolving basalt in the vault of the geode (cycle repetition), with the formation of a viscous gel-like substance containing fluorine, which flows down in jets and polymerizes, thus creating stalactite-like structures. The author uses the photographs of agates found by B. M. Sedov in his numerous hikes to the Ola basalt plateau. The photographs were published in the wonderful book, "Agates from Upstream of the Ola River (Russia)" by B. M. Sedov.
A New Method for Obtaining Global Estimates of Maternal Mortality
Authors: Atmadja Sardjana
Published: March 2022

Background: Maternal mortality is widely regarded as a key indicator of population health and social and economic development. Its rates and trends are closely monitored by the United Nations and others, inspired in part by the Sustainable Development Goals (SDGs), which call for a three-quarter reduction in the maternal mortality ratio by 2015. Unfortunately, the empirical basis for such monitoring is still quite weak, requiring the use of models. statistics to get estimates for most countries.

Objective: In this paper we describe a new method for estimating global rates and trends in maternal mortality. For countries that lack sufficient data for direct estimation of estimates, we use a parametric model that separates maternal deaths from deaths from HIV/AIDS.

Materials and methods: For maternal deaths not associated with HIV/AIDS, the model consists of a hierarchical linear regression with three predictors and variable intercepts for country and region. Estimated uncertainty is assessed by simulating the estimation process, taking into account the variability in both the data and other model inputs. This method was used to derive the most recent set of PBB estimates, published in September 2010. Here, we provide a brief description and description of the approach, including a novel analysis of the components of variability reflected in the uncertainty interval.

Results: Final estimates provide evidence of a more rapid decline in the global maternal mortality ratio than suggested by previous studies, including another study published in April 2010. We compared the findings of the two most recent studies and discussed topics for further research to help resolve differences.
México 2018: escenarios posibles, proyecto de nación, estrategias del desarrollo y crisis de Estado
Authors:   Universidad Autónoma de Zacatecas, Enríquez Pérez Isaac
Published: March 2022

La crisis de sentido forma parte de una crisis civilizatoria de gran envergadura que torna a la política como una praxis vaciada de significación histórica tras la devaluación y declive de la palabra y de la capacidad para imaginar escenarios alternativos de sociedad. En ese sentido, la política mexicana y el proceso electoral de 2018 no escapan a la tendencia global, ello se expresa en la incapacidad de dirección por parte de las élites políticas y en la erosión de su imaginación y su pensamiento utópico para la (re)fundación de un proyecto de nación y para esbozar estrategias de desarrollo que reviertan la lógica desestructuradora de la crisis de Estado que asedia al país.
Elecciones de 2018. Oportunidad para poner fin al ciclo de la hegemonía neoliberal en México. ¡Es el modelo!
Authors:   Universidad Autónoma de Zacatecas, López Villafañe Víctor
Published: March 2022

Luego de la crisis financiera y el ascenso de Miguel de la Madrid a la presidencia en 1982 comenzó un ciclo de profundos cambios económicos y políticos en México que debilitaron el papel del Estado en la economía y promovieron la participación de las empresas extranjeras en el desarrollo del país. El resultado fue la desnacionalización de la economía, la pauperización de los trabajadores y la descomposición social y política en el marco de una violencia generalizada. Los grupos neoliberales han sumido al país en una gigantesca crisis social y las reformas estructurales fomentaron el saqueo de los recursos por grupos extranjeros y nacionales. La corrupción y la impunidad de las clases dirigentes son características esenciales del régimen político neoliberal. Dada la acumulación de agravios y la descomposición social y política, el proceso electoral de 2018 puede facilitar la recomposición del tejido social y brindar una mejor alternativa de desarrollo económico favorable a los trabajadores urbanos y rurales.
La No Factibilidad de la presa Milpillas
Authors:   Universidad Autónoma de Zacatecas, Tetreault Darcy
Published: March 2022

El Estudio de factibilidad de la presa Milpillas señala que la obra permitirá frenar el abatimiento de los acuíferos en la región centro del estado de Zacatecas, lo cual se considera «un efecto importante del proyecto (...) de gran magnitud e importancia». Sin embargo, esta proposición es una falacia. Como se advierte en este texto, luego de hacer un análisis crítico del estudio de factibilidad y del discurso oficial, el proyecto se construye sobre arenas movedizas, por lo que es necesario esbozar algunas alternativas como se intenta hacer al final del artículo.
Nuevo gobierno de AMLO. Hegemonía de Morena y neodesarrollismo
Authors:   Universidad Autónoma de Zacatecas, López Villafañe Víctor
Published: March 2022

El triunfo electoral de Andrés Manuel López Obrador en 2018 reviste un significado histórico: el término de un ciclo de más de tres décadas de neoliberalismo caracterizado por la desnacionalización de la economía, el aumento de la pobreza y las desigualdades sociales, el trabajo precario e informal, y una violencia sin parangón desde la Revolución mexicana. Ahora se erige una nueva hegemonía con el ascenso de un representante del interés general de la nación y de una fracción dominante dentro de un nuevo bloque de poder que le dan consistencia a una nueva unidad intelectual y moral que agrupa a vastos intereses en aras de modificar el futuro del país. En el proyecto neodesarrollista, el Estado recupera su papel de promotor del crecimiento económico cuyos ejes serán la agricultura autóctona y la industria nacional. No obstante, el nuevo régimen capitalista en México contiene grandes contradicciones como parte de un entorno económico de dominio financiero y productivo de corte neoliberal.
Estudio de la fenomenología del crecimiento de células transformadas mediante el empleo de técnicas de escalado dinámico y la aplicación de modelos teóricos
Authors:   , Huergo María Ana Cristina
Published: March 2022

El presente trabajo de tesis presenta el estudio del crecimiento de colonias de líneas celulares aplicando las tecnicas de escalado dinímico con el objeto de determinar si dicho proceso puede asociarse a una “clase universal” que permita interpretar la dinamica de crecimiento de las colonias a traves de un modelo simple. Para ello se emplearon dos tipos de celulas, una originaria de un tejido no neolpasico, línea Vero, y otra de origen tumoral, línea HeLa, y se disenñaron protocolos originales para poder desarrollar frentes de crecimiento de distinta geometría y validar la aplicación de los modelos teíricos desarroliados para sistemas lineales, en sistemas circulares. En el primer capítulo de la tesis se repasan conceptos basicos relacionados con los aspectos biológicos de tumores y líneas celulares [33-36] y en el segundo capítulo se describen brevemente los conceptos relacionados con fractales y escalado dinámico. En el tercer capítulo se presentan los antecedentes bibliográficos del tema en estudio y posteriormente se presenta un capítulo concerniente a los materiales y a la descripcion de las metodologías utilizadas para la preparacion de las colonias y el aníalisis de su crecimiento. En los capítulos cinco y seis se muestran y analizan los resultados obtenidos para el caso de celulas Vero y de celulas HeLa, respectivamente, con el desarrollo de colonias con frente radial y lineal de crecimiento. En el capítulo siete se analiza el efecto de la adicion de metil celulosa al medio de cultivo celular y la influencia de las propiedades físicas del medio sobre la dinamica del crecimiento celular. Finalmente, en el capítulo ocho se discuten los resultados obtenidos y se propone un mecanismo que explique la dinímica de crecimiento de las colonias de líneas celulares en general, presentándose finalmente las conclusiones del trabajo en el capítulo nueve.
PREDIKSI HARGA SAHAM INDEKS IDX30 DI INDONESIA SAAT PANDEMI COVID-19 DENGAN AUTOREGRESSIVE INTEGRATED MOVING AVERAGE (ARIMA)
Authors: Diharjo Bayu , Arief Rifiana
Published: March 2022

Covid-19 (Corona Virus Disease 2019) adalah penyakit akibat serangan virus SARS-Cov-2 (Severe Acute Respiratory Syndrome Coronavirus2) atau lebih dikenal dengan istilah Virus Corona. Adanya pandemi corona ini berpengaruh terhadap berbagai sektor di Indonesia, salah satunya adalah sektor ekonomi dan kegiatan investasi. Hal ini ditandai dengan pelemahan nilai indeks saham dan pertumbuhan jumlah investor yang cukup tinggi. Salah satu Indeks saham adalah Indeks IDX30. Data Indeks IDX30 dapat membantu investor dalam prediksi harga beberapa periode kedepan dalam mengambil keputusan untuk buy atau hold saham untuk mengurangi kerugian dan memperoleh keuntungan. Tujuan penelitian melakukan analisis prediksi harga saham indeks IDX30 di Indonesia saat pandemi Covid-19 menggunakan Autoregressive Integrated Moving Average (ARIMA). Data yang digunakan sebanyak 369 data harian harga penutupan (closing price) Indeks IDX30 tanggal 04 Mei 2020 hingga 08 Mei 2021. Dari hasil pengujian diperoleh model terbaik yaitu ARIMA (0,1,1) dengan nilai error RMSE sebesar 46.11725 (46.11%), MAE sebesar 38.25260 (38.25%), dan MAPE sebesar 7.966014 (7.96%).
Structural and electrical characteristics of ion-induced Si damage during atomic layer etching
Authors: Hirata Akiko , Fukasawa Masanaga , Kugimiya Katsuhisa , Karahashi Kazuhiro , Hamaguchi Satoshi , Hagimoto Yoshiya , Iwamoto Hayato
Published: March 2022

Damage to the underlying Si substrate during the over-etching step of SiN atomic layer etching (ALE) was investigated. CH3F/Ar plasma was applied in the adsorption step, and Ar plasma in the desorption step. ALE increased interface trap density (D
it), whereas Ar plasma did not affect D
it. C, H, and F in the hydrofluorocarbon polymer, knocked-on by Ar, penetrated the Si substrate, which resulted in an increase in D
it. Additionally, H in the polymer layer had a negligible impact on the damage caused by ALE. The H-penetration depth was shallow because the energy transferred from Ar to the H component in the polymer was low. Damage occurred only in the first cycle of ALE because a thick polymer layer, deposited after the second cycle, protected the substrate from additional damage. Thus, precise control of incident ion energy, adsorbed polymer thickness, and polymer composition are required to realize low-damage ALE.
Polarity independent resistive switching in MoS2 nanosheets and PEO-based nanocomposite films
Authors: Deb Rajesh , Pathak Prashanta , Mohapatra Saumya R. , Das Ujjal
Published: March 2022

Here, we report the exfoliation of bulk MoS2 (molybdenum disulfide) into few-layer nanosheets and then prepared nanocomposite films (MoS2-PEO) with poly(ethylene oxide) as the host. We observed nonpolar or polarity independent bistable resistive switching memory in two-terminal devices with indium tin oxide and aluminum (Al) as bottom and top electrodes, respectively. In both bipolar and unipolar operations, it is observed that the biasing direction controls the current conduction mechanism. When the positive bias is applied at the top Al electrode, the low resistance state (LRS) conduction is ohmic type. But in the opposite biasing condition, LRS conduction is space charge controlled. The current–voltage characteristics of bipolar and unipolar switching are distinctly different in terms of their RESET process. In bipolar, the RESET process is very sharp, whereas in unipolar operation it is staggered and step-wise.
Simulation on a non-axisymmetric ring resonator with a nano-antenna for heat-assisted magnetic recording
Authors: Chen Jinghan , Katayama Ryuichi , Sugiura Satoshi
Published: March 2022

Heat-assisted magnetic recording is a technology to improve recording density of hard disk drives. The authors’ group previously proposed a device, in which a Au nano-antenna as a near-field transducer was attached to a GaAs ring resonator as a light source. The ring resonator should stably oscillate with a single mode to generate near-field light at the tip of the nano-antenna with sufficient energy density. A non-axisymmetric ring resonator structure was proposed this time to improve the energy density and laser oscillation stability. When the decenter between the inner and outer circles of the ring resonator increased, the resonance frequency increased and eigenmodes with higher radial mode order disappeared, which leads to stable laser oscillation. Moreover, when the decenter was 200 or 250 nm, the normalized energy density at the tip of nano-antenna increased 1.2–2.4 times compared with an axisymmetric ring resonator structure while keeping the quality factor to more than 5000.
Sensitivity improvement of submicron dynamic displacement measurement system composed of phase-modulated fiber optic interferometer
Authors: Fujimori Mikiya , Takemae Shinya , Tanaka Yosuke
Published: March 2022

We investigated sensitivity improvement of a dynamic displacement measurement system composed of a phase-modulated fiber optic interferometer and a spatial optical system. We introduced a balanced photodetector to enhance the signal-to-noise ratio of the interference signal. The newly developed system was evaluated by using pseudo vibration made by a phase modulator and was proved to be able to measure the dynamic displacement with a high-frequency vibration of 100 kHz even when the reflected optical power from a sample was −50 dBm. We also performed experiments using a rubber or a mouse’s ear bone attached to a piezoelectric element driven by a 100 kHz sinusoidal signal and successfully confirmed that vibration with an amplitude of less than 10 nm was clearly observed even when a reflected optical power was –46.9 dBm.
Stimulated whispering gallery modes emission from green to UVA realized by AlInGaN based quantum wells microtube
Authors: Hu Peng , Li Yufeng , Yang Haifeng , Zhang Ye , Li Qiang , Yun Feng
Published: March 2022

Self-rolling GaN quantum wells microtubes have been fabricated by a photoresist-assisted electrochemical etching method. Different microtubes with whispering gallery modes emitting from the green to ultraviolet range have been demonstrated. Stimulated whispery gallery mode emission from 370 to 460 nm was achieved with lasing line-width less than 0.087 nm and a threshold as low as 0.12 mJ cm−2. Such advanced optical properties can be attributed to the larger mode gain obtained by overlapping the active region with the optical confinement layers. The number of modes was greatly suppressed simultaneously leaving only basic radial modes due to the ultra-thin cavity wall.
Potensial Terapi Antikanker Melalui Senyawa Bioaktif dari Nutrasetikal
Authors:   Fakultas Kedokteran, Universitas Lampung, Bandar Lampung, Lampung, Indonesia, sari Winda Puspita
Published: March 2022

Abstract Purpose: This review aims to examine the current knowledge regarding to the molecular mechanisms by several nutraceuticals, such as retinoids, resveratrol, epigallocatechin 3 gallate, and omega-3 PUFAs to against cancer. Bioactive compounds with high contents in nutraceuticals are considered as complementary components in foods, dietary supplements, and medicines. These compounds can also inhibit carcinogenesis, protect body cells from inflammatory and oxidative processes, and induce anti-proliferative effects in various types of neoplasia. Research Methodology: The method used is a literature review. The literature search was conducted through Pubmed using keywords in the 2012-2021 timeframe. Result: The results obtained are that bioactive compounds from nutraceuticals, such as RSV, retinoids, EGCG, and omega-3 PUFAs, have the ability to influence the growth and development of cancer cells, therefore, nutraceuticals can work as innovative anticancer agents. Limitations: By this method, a thorough literature search may miss important studies that influence conclusions. Contribution: This research can be applied by all of cancer patients because nutraceutical ingredients are easily available throughout the world, including Indonesia.
Fenomena Kekuatan Laba di Masa Covid-19: Suatu Pengujian Keputusan Pembiayaan Utang dan Tindakan Penghindaran Pajak
Authors:   Universitas Bhayangkara Jakarta Raya, Jakarta Selatan, Indonesia, Rossa Elia
Published: March 2022

Abstract Purpose: This study aims to determine the effect of debt financing decisions and tax avoidance actions on earnings power during the COVID-19 period. Method: The sample of this study uses the property and real estate sub-sector companies listed on the Indonesia Stock Exchange (IDX) in 2020. The sample determination uses the purposive sampling method, so that this study obtains a final sample of 33 issuers. The analytical tool used to test the hypothesis is eviews version 11. Results: This study finds that debt financing decisions and tax avoidance have a negative and significant effect on earnings power during the COVID-19 period. Limitations: This study found that debt financing decisions and tax avoidance measures can only affect profit strength during the Covid-19 period by 14,07%. This condition shows that there are other variables that can affect the phenomenon of earnings power during the Covid-19 period, but are not included in this study. In addition, this study is limited to using a final sample of 33 companies out of a total of 77 companies in the property and real estate sub-sector due to the large number of issuers who suffered losses during the COVID-19 period. Contribution: to companies belonging to the property and real estate sub-sector as a form of evaluation of low earning power that can be influenced by debt financing decisions and tax avoidance actions. In addition, this study can also be used as a reference for companies that have the potential to experience a crisis in deciding whether or not to take action to finance debt and even avoid tax. This study also seeks to fill the void of previous studies which were still limited to examining the effect of debt financing decisions and tax avoidance measures on profit strength during the Covid-19 period by involving the property and real estate sub-sectors that had the most impact on the Covid-19 condition.
A COMPARATIVE STUDY BETWEEN ONLAY AND SUBLAY MESH REPAIR IN THE MANAGEMENT OF INCISIONAL HERNIA
Authors: Sushma P. Meghana , Mahalakshmi R.
Published: March 2022

Background: An incisional hernia is one of the common complications of abdominal surgery and the incidence of
incisional hernias continues to be 3 to 11% after laparotomy. The repair of incisional hernia has always been a challenge to
the surgeon. Various operative techniques for the repair of incisional hernia are in practice; however, the management is not standardized. Aim:
To compare onlay mesh placement versus sublay mesh placement in repair of incisional hernias. This prospective study Material and Methods:
comprised of 50 patients with an incisional hernia. A total of 50 cases were included in the study. Of the 50 cases, 25 cases were operated by the
onlay mesh method and 25 by sublay mesh placement.
Results: The operative time for sublay mesh repair was signicantly higher than that of onlay mesh repair, whereas, complications like
haemorrhage, seroma formation and deep surgical site infection leading to extrusion of mesh was higher in onlay mesh repair. The recurrence rate
was found to be 4% in onlay mesh repair whereas it was 0% in sublay mesh repair. Sublay mesh repair, though technically difcult, Conclusion:
and takes more time for surgery has the distinct advantage of reducing the rate of infection and recurrence.
IMPACT OF N 95 MASKS ON QUALITY OF VISION IN SPECTACLE USERS
Authors: Arora Deepak , R Sandhya , T Sangeetha
Published: March 2022

Introduction: wearing masks for a prolonged amount of time can decrease work efciency by causing a host of
physiological or psychological problems. The use of masks, in particular, for extended periods of time causes physical
adverse effects such as difculty breathing, mask-induced acne, rashes, headache and sometimes, impaired cognition.
Objectives: To assess the impact of using N95 masks by a part of the population using spectacles.
Materials and Methods:After taking informed consent, 270 spectacles and mask users were enrolled for this single centre, questionnaire based,
cross-sectional observational study.
Results: A large proportion (70.2%) of the respondents complained of fogging of spectacle lens on wearing N95 masks which impaired their
vision to variable extent and also impaired the daily activity.
Conclusion: This study identied the impact of N95 masks on quality of vision in spectacle users and various recommendations are presented for
prevention and management of these adverse effects.
PREDICTION OF SURGICAL OUTCOMES OF LAPAROSCOPIC CHOLECYSTECTOMY USING INTRAOPERATIVE GRADING SCALE IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY
Authors: Madhu C P , Purushotham Sanhitha
Published: March 2022

The gold standard for gall bladder disease is Laparoscopic cholecystectomy (LC).2 Conversion of LC to open is a
signicant component in terms of conducting a safe surgery, an improved knowledge of factors contributing to
conversion and complications post-surgery would be useful and helpful.1
In this study, a validated scoring system based on intraoperative ndings during LC has been used which allows scoring of these ndings and
standardizes the degree and severity of gall bladder related disease, also predicting the level of difculty in performing the surgery. G10 is a
simple grading scale based on intraoperative parameters, predicts likely difculty in performing the surgery, various surgical outcomes such as
conversion to open cholecystectomy, intraoperative complications, requirement and duration of a drain, duration of hospital stay, and postoperative complications.
G10 score helps the surgeon and team to be better prepared with possible surgical outcomes, need for conversion to laparoscopic
cholecystectomy and can be used as a tool in counselling the patient. G10 score of 5 was considered as the optimum point to predict conversion of
LC to open. Intraoperative decision of conversion from laparoscopic to open cholecystectomy is neither a complication nor should it be
considered as a failure, but rather to be considered as a decision taken to prevent possible intraoperative or postoperative complication and to
ensure patient safety which can be achieved using G10 intraoperative scoring scale.
TO EVALUATE CORRELATION OF BACILLUS CALMETTE GUERIN (BCG) VACCINATION STATUS WITH SEVERITY OF COVID 19 DIAGNOSED PEDIATRIC PATIENTS ADMITTED AT TERTIARY CARE CENTRE OF SOUTH GUJARAT OF WESTERN INDIA.
Authors: Patadia Jigisha , Shah Vijay , Bambharoliya Praful , Bambharoliya Tushar
Published: March 2022

Background: Several studies have documented that BCG vaccine which is a part of Primary Immunization in certain
countries not only prevent occurrence of Tuberculosis in children but also have numbers of heterologus protective effects
which subsequently decreases the chances of occurrence of sepsis and various respiratory infections during childhood. In the present pandemic of
SARS-Cov2 it is observed worldwide that Pediatric patients neither show severity nor adverse outcome of COVID 19 as compare to Adult
population. Objectives: 1. To nd out the proportion of BCG vaccination among COVID 19 positive paediatric patients admitted in a tertiary
care centre. 2. To document the progress of the COVID 19 disease between BCG vaccinated COVID 19 patients and BCG non-vaccinated
COVID 19 patients admitted in the tertiary care centre. It is a cross Methods: sectional study conducted in All COVID 19 positive patients
admitted in the department of Paediatrics of the tertiary care centre during the study period shall be included. All 57 COVID 19 positive Results:
children were BCG vaccinated. Majority of children (98.2%) recovered from COVID 19 and discharge from hospital, only 1.8% death occurred
due to COVID 19 in children. we conclude that BCG vaccination has a protective Conclusion: effect against severity of COVID-19 in childhood.
The main limitation of study, there were not any unvaccinated covid-19 positive children admitted in hospital during study period.
DIAGNOSTIC AND PROGNOSTIC APPROACH OF MUTRA PAREEKSHA IN AYURVEDA - A REVIEW
Authors: Tiwari Sonal Shukla
Published: March 2022

The Fundamental Principles of Ayurveda were laid down after many times of experimentation, hence still applicable even
in modern era. According to Aacharya Charak ,it is important to know preliminary cause of disease before treatment. For
which Rog-rogipareeksha is must. Mutra Pareeksha among Astasthanapareeksha have been given much importance because urine is the end
product of all metabolic activities of the body, thus it indicates health status. This article is aimed to collect all scattered data related to Mutra
Pareeksha in various Ayurvedic texts. The changes pertaining to Mutra is described under various disease conditions as symptoms are compiled
to evaluate diagnostic approach of Mutra Pareeksha.
Material has been collected from ancient ayurvedic texts, research journals and electronic database. . In this article efforts have been made to
collect various scattered data related to Mutra pareeksha in different disease symptoms described in Samhitas. We can judge Doshik involvement
and type of disease by mutrapareeksha. Tail bindupareeksha is vital part of Mutrapareeksha which tells about diagnosis and prognosis of disease.
Laghutrayees and various texts like Vasavarajiyam, Yogratnakar provide more elaborative information as compared to Brihatrayees.
The Ayurveda classics and their examination approaches are still reliable. Ultimate aim of these methods are to determine proper physiology of
various systems of body. In comparison with modern laboratory investigation Mutrapareeksha may be used as a cost effective, diagnostic and
prognostic tool. It will be helpful to access treatment plan for diseases.
A STUDY TO ASSESS THE EFFECTIVENESS OF STRUCTURED TEACHING PROGRAMME ON KNOWLEDGE REGARDING CARDIO PULMONARY RESUSCITATION AMONG B.SC.NURSING 1ST YEAR STUDENTS IN SELECTED COLLEGES OF NURSING , BHILAI, C.G.
Authors: Kannammal Kannammal , Rajni Rajni , Pal Monika , Rizvi Danish
Published: March 2022

Background:Cardio pulmonary resuscitation is an important medical procedure which is performed in an effort to
manually preserved intact brain function until further measure are taken to restore normal spontaneous blood circulation
and breathing in a person in cardiac arrest.It is a combination of rescue breathing and chest compression .which is delivered to the victim who is to
be in cardiac arrest being important members of the health care team medical student are deemed to passes the basic skills and expertise whichare
needed to perform CPR. To assess the knowledge score regarding cardio pulmonary resuscitation among B Objectives:1. .Sc. nursing 1st year
student before intervention and after intervention. 2.To compare knowledge score regarding cardio pulmonary resuscitation among B.Sc.
nursing 1st year student before and after intervention.3. To nd out the association in knowledge score regarding cardio pulmonary resuscitation
among B.Sc. nursing 1st year student with their selected socio demographic variables before intervention. Method: In this study the research
approach was pre experimental pre-test & pos-test design without control group design was applied. Total 40 samples selected by purposive
sampling technique. The intervention Structured Teaching Programme was introduced to the group after the pre test. Knowledge was assessed by
self structured questionnaire assessed by questionnaire before and after the intervention. Results:The result revealed that meanpre-test 82.5 %
students had inadequate knowledge and 17.5 % students had moderate knowledge. And during post test 85% students had moderate knowledge
and 15% students had adequate knowledge. The study concluded that, structured teaching program Conclusion: me about Cardio Pulmonary
Resuscitationshould be implemented to improve the knowledge amongthe B.Sc. nursingstudents.
OVERVIEW OF RICHTER’S INGUINAL HERNIA WITH AN ORIGINAL INTRAOPERATIVE EXPERIENCE
Authors: Pandey Pooja , Ghosh Abhishek , Srivastava A. K.
Published: March 2022

Aim &Objective– Insouciance of thickened hernial sac may leads to the complications which progresses to lose a life of the patient. The
mortality and morbidity rates can be reduced by having a keen knowledge on the clinical diagnosis of long standing inguinal hernia.
Material and method – In a year of covid pandemic (December 2020-January 2021) 56 cases of inguinal hernia is selected for study giving an emphasis on Richter's
hernia or partial enterocele. Patients with ventral hernia, femoral hernia, with severe comorbidities ie- bronchial asthma, coronary artery disease were excluded.
Result- Having male preponderance in 56 inguinal hernia cases 5 of them got supercial surgical site infection whereas rest of them have ECOG
performance index of 1. The schematic ow chart on approach to Richter's inguinal hernia has been proposed
Conclusion- It's always better to go for exploratory laparotomy in a long standing case of hernia where history of intermittent reducibility is present.
Therefore, visualizing the content of thickened sac is very important in order to have a healthy recovery of the patient.
Is the Second Law of Thermodynamics Able to Classify Drugs?
Authors: Schwartz Laurent , Benichou Luc , Schwartz Jules , Pontié Maxime , Henry Marc
Published: March 2022

Specialization characterizes pharmacology, with the consequence of classifying the various treatments into unrelated categories. Treating a specific disease usually requires the design of  a specific drug. The second law of thermodynamics is the driving force both for chemical reactions and for life. It applies to diseases and treatment. In most common diseases, there is a metabolic shift toward anabolism and anaerobic glycolysis, resulting in the release of entropy in the form of biomass. In accordance with the second principle of thermodynamics, treatment should aim at decreasing the entropy flux, which stays inside the body in the form of biomass. Most treatments aim at increasing the amount of entropy that is released by the cell in the form of thermal photons. As clinically different diseases often requires similar drugs, this calls for reinforcement in a quest for a single unified framework. For example, treatment of aggressive autoimmune diseases requires the same cytotoxic chemotherapy than for cancer. This strongly suggests that despite their apparent disparity, there is an underlying unity in the diseases and the treatments. The shift toward increased entropy release in the form of heat offers sound guidelines for the repurposing of drugs.