bluuebunny/crossref_metadata_2025 huggingface dataset:
Americanos por brasileiros no fim do século XIX
Authors: Dimas Antonio
Published: April 2017

In the end of 1893, Eduardo Prado stirred quite a buzz in the Brazilian intellectual and political scene when he published The American Illusion, which was immediately confiscated by the government of Floriano Peixoto, who wanted to avoid spurring clashes with the American government. In 1899, Oliveira Lima published In the United States, a work which was clearly supportive of America. Between those two works, the young Adolfo Caminha published his In the Country of the Yankees, an account of the trip he took as an ensign on the Almirante Barroso, in an official visit to New Orleans and New York. Those works, along with some chronicles by Olavo Bilac and the criticism by José Veríssimo, tone down the historical Brazilian Francophilia and bring into it an alternative pointing to the English language universe
DaMatta: cronista de duas culturas
Authors: Laraia Roque de Barros
Published: April 2017

The fact that Roberto DaMatta lived for a long time as a visiting lecturer at Notre Dame University in Indiana provided him with the opportunity of undertaking an ethnographic observation of the behavior of the American people. Such observations were carried out through his frequent contacts with university staff members and mainly in his daily life activities. Through his long walks along the streets of Salt Bend, he drew his comparisons with the observations carried out in Brazil. An author of a classical text on the role of the street in Brazilian culture, it was only natural that he focused his attention on the meaning of the street to Americans. During his stay, he produced numerous chronicles for many Brazilian newspapers. Many of those chronicles were compiled into a book
Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia
Authors: Golsari Amir , Bittersohl Diana , Cheng Bastian , Griem Pia , Beck Christoph , Hassenstein Andrea , Nedelmann Max , Magnus Tim , Fiehler Jens , Gerloff Christian , Thomalla Götz
Published: April 2017

Background and Purpose—

We aimed to determine the incidence of co-occurring cerebral ischemia, extent of cerebral small vessel disease, and vascular risk profile of patients with acute retinal ischemia.

Methods—

RETIS (Frequency of Acute Silent Brain Infarction and Systematic Evaluation of Stroke Risk in Retinal Ischemia) was a single-center, prospective, observational study comprising ophthalmologic examination, brain magnetic resonance imaging, and extensive diagnostic work-up of vascular risk factors and stroke cause. Silent brain infarctions were identified on diffusion-weighted imaging, leukoaraiosis was quantified on fluid-attenuated inversion recovery sequences, and carotid artery stenosis was assessed by carotid ultrasound.

Results—

Of 112 patients with retinal ischemia, 77 (68.8%) had retinal arterial occlusion, and 35 (31.3%) presented with amaurosis fugax. Silent brain infarctions were found in 17 (15.1%) patients. Internal carotid artery stenosis was present in 19 (17.0%) and severe leukoaraiosis in 29 (25.9%) patients. Atrial fibrillation was detected in 14 (12.5%) patients. Patients with silent brain infarctions had higher rates of internal carotid artery stenosis (35.3% versus 13.7%;
P
=0.029) than those without, whereas leukoaraiosis and vascular risk factors were comparable between groups. Internal carotid artery stenosis was the only significant predictor of silent brain infarctions in multivariate analysis (odds ratio, 4.27; 95% confidence interval, 1.06–17.23).

Conclusions—

Silent cerebral ischemia is present in about 1 in 7 patients with retinal ischemia. The high rate of symptomatic internal carotid artery stenosis suggests that large artery atherosclerosis plays a major role in the pathogenesis of acute retinal ischemia.
Changes in the Employment Status and Risk of Stroke and Stroke Types
Authors: Eshak Ehab S. , Honjo Kaori , Iso Hiroyasu , Ikeda Ai , Inoue Manami , Sawada Norie , Tsugane Shoichiro
Published: April 2017

Background and Purpose—

Because of limited evidence, we investigated a long-term impact of changes in employment status on risk of stroke.

Methods—

This was a prospective study of 21 902 Japanese men and 19 826 women aged 40 to 59 years from 9 public health centers across Japan. Participants were followed up from 1990 to 1993 to the end of 2009 to 2014. Cox proportional hazard ratio of stroke (incidence and mortality) and its types (hemorrhagic and ischemic) was calculated according to changes in the employment status within 5 years interval between 1990 to 1993 and 1995 to 1998 (continuously employed, job loss, reemployed, and continuously unemployed).

Results—

During the follow-up period, 973 incident cases and 275 deaths from stroke in men and 460 cases and 131 deaths in women were documented. Experiencing 1 spell of unemployment was associated with higher risks of morbidity and mortality from total, hemorrhagic, and ischemic stroke in both men and women, even after propensity score matching. Compared with continuously employed subjects, the multivariable hazard ratio (95% confidence interval) for total stroke incidence in job lost men was 1.58 (1.18–2.13) and in job lost women was 1.51 (1.08–2.29), and those for total stroke mortality were 2.22 (1.34–3.68) in men and 2.48 (1.26–4.77) in women. The respective hazard ratio (95% confidence interval) in reemployed men was 2.96 (1.89–4.62) for total stroke incidence and 4.21 (1.97–8.97) for mortality, whereas those in reemployed women were 1.30 (0.98–1.69) for incidence and 1.28 (0.76–2.17) for mortality.

Conclusions—

Job lost men and women and reemployed men had increased risks for both hemorrhagic and ischemic stroke incidence and mortality.
Separating Event-related Potential Effects for Conceptual Fluency and Episodic Familiarity
Authors: Bader Regine , Mecklinger Axel
Published: April 2017

ERP old/new effects have been associated with different subprocesses of episodic recognition memory. The notion that recollection is reflected in the left parietal old/new effect seems to be uncontested. However, an association between episodic familiarity and the mid-frontal old/new effect is not uncontroversial. It has been argued that the mid-frontal old/new effect is functionally equivalent to the N400 and hence merely reflects differences in conceptual fluency between old and new items. Therefore, it is related to episodic familiarity only in situations in which conceptual fluency covaries with familiarity. Alternatively, the old/new effect in this time window reflects an interaction of episodic familiarity and conceptual processing with each making a unique functional contribution. To test this latter account, we manipulated conceptual fluency and episodic familiarity orthogonally in an incidental recognition test: Visually presented old and new words were preceded by either conceptually related or unrelated auditory prime words. If the mid-frontal old/new effect is functionally distinguishable from conceptual priming effects, an ERP contrast reflecting pure priming (correct rejections in the related vs. unrelated condition) and a contrast reflecting priming plus familiarity (hits in the related vs. correct rejections in the unrelated condition) should differ in scalp distribution. As predicted, the pure priming contrast had a right-parietal distribution, as typically observed for the N400 effect, whereas the priming plus familiarity contrast was significantly more frontally accentuated. These findings implicate that old/new effects in this time window are driven by unique functional contributions of episodic familiarity and conceptual processing.
Modulation of Oscillatory Power and Connectivity in the Human Posterior Cingulate Cortex Supports the Encoding and Retrieval of Episodic Memories
Authors: Lega Bradley , Germi James , Rugg Michael D.
Published: April 2017

Existing data from noninvasive studies have led researchers to posit that the posterior cingulate cortex (PCC) supports mnemonic processes: It exhibits degeneration in memory disorders, and fMRI investigations have demonstrated memory-related activation principally during the retrieval of memory items. Despite these data, the role of the PCC in episodic memory has received only limited treatment using the spatial and temporal precision of intracranial EEG, with previous analyses focused on item retrieval. Using data gathered from 21 human participants who underwent stereo-EEG for seizure localization, we characterized oscillatory patterns in the PCC during the encoding and retrieval of episodic memories. We identified a subsequent memory effect during item encoding characterized by increased gamma band oscillatory power and a low-frequency power desynchronization. Fourteen participants had stereotactic electrodes located simultaneously in the hippocampus and PCC, and with these unique data, we describe connectivity changes between these structures that predict successful item encoding and that precede item retrieval. Oscillatory power during retrieval matched the pattern we observed during encoding, with low-frequency (below 15 Hz) desynchronization and a gamma band (especially high gamma, 70–180 Hz) power increase. Encoding is characterized by synchrony between the hippocampus and PCC, centered at 3 Hz, consistent with other observations of properties of this oscillation akin to those for rodent theta activity. We discuss our findings in light of existing theories of episodic memory processing, including the information via desynchronization hypothesis and retrieved context theory, and examine how our data fit with existing theories for the functional role of the PCC. These include a postulated role for the PCC in modulating internally directed attention and for representing or integrating contextual information for memory items.
The number of male conspecifics affects the odour preferences and the copulatory behaviour of male meadow voles, Microtus pennsylvanicus
Authors: Ferkin Michael H. , Ferkin Adam C.
Published: April 2017

We hypothesized that male meadow voles adjust their odour preferences and sexual behaviours in response to the presence and number of male conspecifics they perceive to have visited a sexually receptive female conspecific. Male voles only preferred the odour of the female previously associated with 3 or 5 males to that of the unfamiliar female. Male voles also had a shorter latency to mate and a shorter mating duration when they were paired with the female that was previously associated with the bedding of 3 or 5 males compared to males paired with an unfamiliar female. Mating and reproductive success, however, were similar for males paired with either female. Thus, male voles use public information provided by scent marks of male conspecifics and adjust their responses in favour of a female that they perceive to been visited by several males, although she may represent a high risk of sperm competition.
Characterisation of populations of Heterodera trifolii Goffart, 1932 (Nematoda: Heteroderidae) in Japan and their phylogenetic relationships with closely related species
Authors: Sekimoto Shigeyuki , Uehara Taketo , Mizukubo Takayuki
Published: April 2017

The Japanese populations of the clover cyst nematode,Heterodera trifolii, were characterised morphologically, morphometrically and molecularly. The morphology and morphometrics of six Japanese populations ofH. trifoliiwere in congruence with those of previous descriptions of this species from Germany, Italy, Japan, New Zealand, Russia, The Netherlands, UK and USA. The results of the phylogenetic analyses of the D2-D3 expansion segments of 28S rRNA gene and theCOImtDNA gene sequences discriminatedH. trifoliifrom most of the other closely related species of theSchachtiigroup. The intraspecific sequence differences in theSchachtiigroup were much higher inCOIthan in D2-D3. TheH. trifoliipopulations displayed very low levels of intraspecific variations (up to 0.3%) in theCOImtDNA gene sequences. The phylogenetic relationships ofH. trifoliiwith otherHeteroderaspecies, as inferred from the analyses of the ITS rRNA gene, D2-D3 of 28S rRNA gene andCOImtDNA gene sequences, were determined.
Similarities in Autistic and Neurotypical Visual–Haptic Perception When Making Judgements About Conflicting Sensory Stimuli
Authors: Poole Daniel , Poliakoff Ellen , Gowen Emma , Couth Samuel , Champion Rebecca A. , Warren Paul A.
Published: April 2017

A number of studies have shown that multisensory performance is well predicted by a statistically optimal maximum likelihood estimation (MLE) model. Under this model unisensory estimates are combined additively and weighted according to relative reliability. Recent theories have proposed that atypical sensation and perception commonly reported in autism spectrum condition (ASC) may result from differences in the use of reliability information. Furthermore, experimental studies have indicated that multisensory processing is less effective in those with the condition in comparison to neurotypical (NT) controls. In the present study, adults with ASC () and a matched NT group () completed a visual–haptic size judgement task (cf. Gori et al., 2008) in which participants compared the height of wooden blocks using either vision or haptics, and in a dual modality condition in which visual–haptic stimuli were presented in size conflict. Participants with ASC tended to produce more reliable estimates than the NT group. However, dual modality performance was not well predicted by the MLE model for either group. Performance was subsequently compared to alternative models in which the participant either switched between modalities trial to trial (rather than integrating) and a model of non-optimal integration. Performance of both groups was statistically comparable to the cue-switching model. These findings suggest that adults with ASC adopted a similar strategy to NTs when processing conflicting visual–haptic information. Findings are discussed in relation to multisensory perception in ASC and methodological considerations associated with multisensory conflict paradigms.
Cue Integration for Continuous and Categorical Dimensions by Synesthetes
Authors: Bankieris Kaitlyn R. , Bejjanki Vikranth Rao , Aslin Richard N.
Published: April 2017

For synesthetes, sensory or cognitive stimuli induce the perception of an additional sensory or cognitive stimulus. Grapheme–color synesthetes, for instance, consciously and consistently experience particular colors (e.g., fluorescent pink) when perceiving letters (e.g.,u). As a phenomenon involving multiple stimuli within or across modalities, researchers have posited that synesthetes may integrate sensory cues differently than non-synesthetes. However, findings to date present mixed results concerning this hypothesis, with researchers reporting enhanced, depressed, or normal sensory integration for synesthetes. In this study wequantitativelyevaluated the multisensory integration process of synesthetes and non-synesthetes using Bayesian principles, rather than employing multisensory illusions, to make inferences about the sensory integration process. In two studies we investigated synesthetes’ sensory integration by comparing human behavior to that of an ideal observer. We found that synesthetes integrated cues for both continuous and categorical dimensions in a statistically optimal manner, matching the sensory integration behavior of controls. These findings suggest that synesthetes and controls utilize similar cue integration mechanisms, despite differences in how they perceive unimodal stimuli.
Speciation in Indo-Pacific swiftlets (Aves: Apodidae): integrating molecular and phenotypic data for a new provisional taxonomy of the Collocalia esculenta complex
Authors: RHEINDT FRANK E. , CHRISTIDIS LES , NORMAN JANETTE A. , EATON JAMES A. , SADANANDAN KEREN R. , SCHODDE RICHARD
Published: April 2017

White-bellied swiftlets of the Collocalia esculenta complex constitute a radiation of colony-breeding swifts distributed throughout the tropical Indo-Pacific region. Resolution of their taxonomy is challenging due to their morphological uniformity. To analyze the evolutionary history of this complex, we combine new biometric measurements and results from plumage assessment of museum specimens with novel as well as previously published molecular data. Together, this body of information constitutes the largest systematic dataset for white-bellied swiftlets yet compiled, drawn from 809 individuals belonging to 32 taxa for which new molecular, biometric, and/or plumage data are presented. We propose changing the classification of white-bellied swiftlets, for which two species are currently recognized, to elevate eight regional forms to species level, and we also describe two new subspecies. The ten taxa we recommend recognizing at the species level are: Collocalia linchi (Java to Lombok, Sumatran hills), C. dodgei (montane Borneo), C. natalis (Christmas Island), C. affinis (Greater Sundas, including the Thai-Malay Peninsula and Andaman–Nicobar Islands), C. marginata (Philippines), C. isonota (Philippines), C. sumbawae (west Lesser Sundas), C. neglecta (east Lesser Sundas), C. esculenta (Sulawesi, Moluccas, New Guinea, Bismarck Archipelago, Solomon Islands), and C. uropygialis (Vanuatu, New Caledonia). Future molecular and morphological work is needed to resolve questions of speciation and population affinities in the Philippines, Christmas Island, Wallacea and central Melanesia, and to shed light on historic diversification and patterns of gene flow in the complex.
Nomenclatural changes in the Australasian gall-inducing genus Apiomorpha Rübsaamen (Hemiptera: Coccomorpha: Eriococcidae)
Authors: MILLS PENELOPE J. , GULLAN PENNY J. , COOK LYN G.
Published: April 2017

Apiomorpha Rübsaamen, 1894 was erected as a replacement name for Brachyscelis Schrader, 1863 that was preoccupied in the Coleoptera (Chrysomelidae: Brachyscelis Germar, 1834). Apiomorpha is a genus of eriococcid scale insects that induce galls on Eucalyptus (Myrtaceae) in Australia and New Guinea (Szent-Ivany & Womersley 1962; Gullan 1984; Gullan et al. 2005). In his original description of the genus, Schrader (1863a) included six species, of which B. citricola Schrader was subsequently recognised as a nomen nudum (Froggatt 1921). Among the other five, B. pileata Schrader was later designated as the type species of Apiomorpha by Lindinger (1937). Also amongst these five was B. ovicola Schrader, for which Schrader described and illustrated galls of males and females on twigs and leaves of Eucalyptus haemastoma (Schrader 1863a, plate II, figs a, e) in or near Sydney, New South Wales (NSW). He stated that his species names reflected the shape of the galls of adult females; hence those of B. ovicola can be interpreted as being egg-shaped and were illustrated as such by Schrader (1863a). Galls of males of B. ovicola he described and illustrated as trumpet-shaped.
Estimating Range-Dependent Evaporation Duct Height
Authors: Zhao Xiaofeng , Yardim Caglar , Wang Dongxiao , Howe Bruce M.
Published: April 2017

The refractivity from clutter (RFC) technique has been proved to be an effective way to estimate atmospheric duct structure. An important issue for RFC is how to make the estimate more robust, especially in range-dependent ducting conditions. Traditionally, statistical inversion methods need a large number of forward propagation model runs to obtain an acceptable result. Especially when the parameter search space is multidimensional, these methods are prone to being trapped into local optimal solutions. Recently published results (Zhao and Huang) indicate that the adjoint parabolic equation (PE) method holds promise for real-time estimation of one-dimensional refractive index structure from radar sea clutter returns. This paper is aimed at extending the adjoint PE method to range-dependent evaporation duct cases, with a log-linear relationship describing duct structures. Numerical simulations are used to test the performance of this method and the results are compared with that retrieved using a genetic algorithm. Both noise-free and 3-dB additive Gaussian noise clutter simulations are considered, as well as linearly and nonlinearly varying duct height with range.
The Evolution of Management Models: A Neo-Schumpeterian Theory
Authors: Bodrožić Zlatko , Adler Paul S.
Published: April 2017

In the last century and a half, U.S. industry has seen the emergence of several different management models. We propose a theory of this evolution based on three nested and interacting processes. First, we identify several successive waves of technological revolution, each of which prompted a corresponding wave of change in the dominant organizational paradigm. Second, nested within these waves, each of these organizational paradigms emerged through two successive cycles—a primary cycle that generated a new management model making the prior organizational paradigm obsolete, and a secondary cycle that generated another model that mitigated the dysfunctions of the primary cycle’s model. Third, nested within each cycle is a problem-solving process in which each model’s development passed through four main phases: (1) identification of a widespread organizational and management problem, (2) creation of innovative managerial concepts that offer various solutions to this problem, (3) emergence and theorization of a new model from among these concepts, and (4) dissemination and diffusion of this model. By linking new models’ emergence to specific technological revolutions, we can explain changes in their contents. By integrating a dialectical account of the paired cycles with an account of the waves of paradigm change, we can see how apparently competing models are better understood as complementary pairs in a common paradigm. And by unpacking each model’s phases of development, we can identify the roles played by various actors and management concepts in driving change in the models’ contents and see the agency behind these structural changes.
Is the Complication Rate of Ulnar and Radial Approaches for Coronary Artery Intervention the Same?
Authors: Bi Xile , Wang Qingsheng , Liu Defeng , Gan Quan , Liu Li
Published: April 2017

We compared the clinical outcomes of patients who underwent coronary artery intervention by the transulnar and transradial artery approaches. In this 1 year, single-center study, patients were randomized to either a radial artery (RA) or ulnar artery (UA) group. Of 538 patients, the primary outcome, arterial occlusion of a forearm artery, occurred in 21 of 225 patients in the RA group compared to 6 of 220 patients in the UA group (9.3% vs 2.7%, P = .007). The rate of arterial occlusion was significantly lower following ulnar access compared to radial (odds ratio [OR] = 3.85, P = .006). A higher risk of occlusion was associated with repeated procedures rather than a single procedure (OR = 5.14, P = .003), smoking (OR = 2.39, P = .04), and arterial to sheath diameter ratio of ≤1 (OR = 2.62, P = .03). However, the disadvantage of UA was an increase of incidence of hematomas (13.2% vs 5.8%, P = .01) and symptoms of discomfort (15.5% vs 5.8%, P = .002). In conclusion, the transulnar strategy proved to be noninferior to the transradial approach for coronary procedures ( ClinicalTrials.gov Identifier: NCT01979627).
Analytical and Numerical Characterization of Autocorrelation and Perturbation-Correlation Moving-Window Methods
Authors: Lee Young Jong
Published: April 2017

Moving-window (MW) approaches to two-dimensional correlation spectroscopy (2D-COS) make it possible to characterize spectral changes occurring in a narrow range of perturbation variable (e.g., time, temperature, and concentration). Despite the wide range of application, the physical meanings of MW correlation intensities have been only qualitatively associated with the direction and curvature of spectral intensity change with regard to a perturbation variable. Here are full and simplified analytical expressions of autocorrelation moving-window (ACMW) and synchronous and asynchronous perturbation-correlation moving-window ( s-PCMW and as-PCMW) intensities. When the window is set sufficiently narrower than the bandwidth of spectral change, the square root of ACMW intensity and s-PCMW intensity becomes proportional to the first order derivative, and as-PCMW intensity becomes proportional to the negative of the second order derivative. This paper demonstrates that both ACMW and PCMW profiles can be significantly altered by non-uniform perturbation spacing. It is also found that intensity noise can cause ACMW to display a false offset drift. This analytical and numerical characterization of the two MW correlation intensities elucidates their physical meanings and ascertains the analysis conditions for reliable interpretation.
A Rapid Identification Method for Calamine Using Near-Infrared Spectroscopy Based on Multi-Reference Correlation Coefficient Method and Back Propagation Artificial Neural Network
Authors: Sun Yangbo , Chen Long , Huang Bisheng , Chen Keli
Published: April 2017

As a mineral, the traditional Chinese medicine calamine has a similar shape to many other minerals. Investigations of commercially available calamine samples have shown that there are many fake and inferior calamine goods sold on the market. The conventional identification method for calamine is complicated, therefore as a result of the large scale of calamine samples, a rapid identification method is needed. To establish a qualitative model using near-infrared (NIR) spectroscopy for rapid identification of various calamine samples, large quantities of calamine samples including crude products, counterfeits and processed products were collected and correctly identified using the physicochemical and powder X-ray diffraction method. The NIR spectroscopy method was used to analyze these samples by combining the multi-reference correlation coefficient (MRCC) method and the error back propagation artificial neural network algorithm (BP-ANN), so as to realize the qualitative identification of calamine samples. The accuracy rate of the model based on NIR and MRCC methods was 85%; in addition, the model, which took comprehensive multiple factors into consideration, can be used to identify crude calamine products, its counterfeits and processed products. Furthermore, by in-putting the correlation coefficients of multiple references as the spectral feature data of samples into BP-ANN, a BP-ANN model of qualitative identification was established, of which the accuracy rate was increased to 95%. The MRCC method can be used as a NIR-based method in the process of BP-ANN modeling.
Racism: Origin and Theory
Authors: Bowser Benjamin P.
Published: April 2017

This is a review of the theoretical development of the concept of racism. From its 1960s activist roots, the concept lost its theoretical content in its 1970s popularization. Now racism describes virtually anything having to do with racial conflict. The concept is reintroduced and used to analyze the post-1970s race relations propositions. The declining significance of race, symbolic racism, color-blind racism, and unconscious racism missed the structural regressions brought on by the “southern strategy” to mask indirect and covert ways to continue racial oppression. As a result, the new Jim Crow was missed in race relations since the 1980s. A reconsideration of the theory of racism calls for a strategic approach to race relations research. Research should focus on the etiology of racism among European Americans and the central role played by White elites and the media in maintaining historic cultural and institutional arrangements.
A Consensus-Based Set of Measures for Oral Health Care
Authors: Baâdoudi F. , Trescher A. , Duijster D. , Maskrey N. , Gabel F. ,   The ADVOCATE Consortium, van der Heijden G.J.M.G. , Listl S. , Egberts Barry , Christensen Lisa Bøge , Douglas Gail , Eaton Kenneth , Gavin Gerard , Walker Jochen , Nagy Gabor , O’Hanlon Karen , Taylor Andrew , Whelton Helen , Woods Noel
Published: April 2017

Increasingly more responsive and accountable health care systems are demanded, which is characterized by transparency and explicit demonstration of competence by health care providers and the systems in which they work. This study aimed to establish measures of oral health for transparent and explicit reporting of routine data to facilitate more patient-centered and prevention-oriented oral health care. To accomplish this, an intermediate objective was to develop a comprehensive list of topics that a range of stakeholders would perceive as valid, important, and relevant for describing oral health and oral health care. A 4-stage approach was used to develop the list of topics: 1) scoping of literature and its appraisal, 2) a meeting of experts, 3) a 2-stage Delphi process (online), and 4) a World Café discussion. The aim was to create consensus through structured conversations via a range of stakeholders (general dental practitioners, patients, insurers, and policy makers) from the Netherlands, Germany, the United Kingdom, Ireland, Hungary, and Denmark. The study was part of the ADVOCATE project, and it resulted in a list of 48 topics grouped into 6 clusters: 1) access to dental care, 2) symptoms and diagnosis, 3) health behaviors, 4) oral treatments, 5) oral prevention, and 6) patient perception. All topics can be measured, as they all have a data source with defined numerators and denominators. This study is the first to establish a comprehensive and multiple-stakeholder consented topic list designed for guiding the implementation of transparent and explicit measurement of routine data of oral health and oral health care. Successful measurement within oral health care systems is essential to facilitate learning from variation in practice and outcomes within and among systems, and it potentiates improvement toward more patient-centered and prevention-oriented oral health care.
Scientific writing in the laboratory animal sciences
Authors: Riederer Beat M. , Bomzon Arieh , Jirkof Paulin
Published: April 2017

Good communication is important for the dissemination of research results. Here, we summarize the advice that was given to authors at the LA seminar on scientific writing at the FELASA Congress 2016 in Brussels, Belgium on 13–16 June 2016, with the aim of improving the quality of submitted papers and of avoiding common mistakes in scientific reports. See www.felasa2016.eu .
‘We Call it Jail Craft’: The Erosion of the Protective Discourses Drawn on by Prison Officers Dealing with Ageing and Dying Prisoners in the Neoliberal, Carceral System
Authors: Peacock Marian , Turner Mary , Varey Sandra
Published: April 2017

The UK prison population has doubled in the last decade, with the greatest increases among prisoners over the age of 60 years, many of whom are sex offenders imprisoned late in life for ‘historical’ offences. Occurring in a context of ‘austerity’ and the wider neoliberal project, an under-researched consequence of this increase has been the rising numbers of ‘anticipated’ prison deaths; that is, deaths that are foreseeable and that require end of life care. We focus here on ‘jail craft’; a nostalgic, multi-layered, narrative or discourse, and set of tacit practices which are drawn on by officers to manage the affective and practical challenges of working with the demands of this changed prison environment. Utilising findings from an empirical study of end of life care in prisons, we propose that the erosion of jail craft depletes protective resources and sharpens the practical consequences of neoliberal penal policies.
A brief treatment for fear of heights
Authors: Arroll Bruce , Henwood Suzanne M , Sundram Fred I , Kingsford Douglas W , Mount Vicki , Humm Steve P , Wallace Henry B , Pillai Avinesh
Published: April 2017

Objective

To assess the effectiveness of a novel imaginal intervention for people with acrophobia.

Methods

The design was a randomized controlled trial with concealed randomization and blinded to other participants’ intervention. The intervention was a single novel imaginal intervention session or a 15-min meditation. The setting was in Auckland, New Zealand. The participants were a convenience sample of the public with a score >29 on the Heights Interpretation Questionnaire (HIQ), a questionnaire validated against actual height exposure. The primary outcomes were the proportion of participants with a score <26 on the HIQ at eight weeks and difference between the HIQ scores between the two arms of the study.

Results

Ninety-eight participants (92%) returned their questionnaire and were included in the intention to treat analysis. The HIQ score <26 was 34.6% (18/52) in the intervention group and 15.2% (7/46) in the control group RR = 2.26, 95% CI (1.05, 4.95) and p = 0.028. The numbers needed to treat is six 95% CI (3 to 36). Participants with scores <26 report their fear of heights is very much improved. There was a 4.5-point difference in the HIQ score at eight weeks (p = 0.055) on the multiple regression analysis.

Conclusions

This is the first randomized trial of this novel imaginal intervention which is probably effective, brief, easily learnt, and safe. It may be worth considering doing this prior to some of the longer or more expensive exposure therapies. This study will be of interest to family doctors, psychiatrists, and psychologists.
The buffering effect of peer support on the links between family rejection and psychosocial adjustment in LGB emerging adults
Authors: Parra Luis A. , Bell Timothy S. , Benibgui Michael , Helm Jonathan L. , Hastings Paul D.
Published: April 2017

Lesbian, gay, and bisexual (LGB) emerging adults often seek support from their peers if they lack support from their family of origin. We predicted that peer social support would moderate the link between negative family relationships and psychosocial adjustment, such that in the context of family rejection, experiencing more peer support would predict lower levels of anxiety, depression, and internalized homonegativity (IH) and higher self-esteem. Sixty-two (27 females) LGB individuals (ages 17–27, M = 21.34 years, SD = 2.65) reported on their families’ attitudes toward homosexuality, experiences of family victimization, peer social support, anxiety and depression symptoms, IH, and self-esteem. Results showed that peer social support moderated the link between negative family attitudes and anxiety and also moderated the link between family victimization and depression. The moderating effects suggest that having a supportive peer group may protect against mental health problems for LGB emerging adults who lack support from their family of origin.
Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood–brain barrier via the activin receptor-like kinase-1 receptor
Authors: Abdullahi Wazir , Brzica Hrvoje , Ibbotson Kathryn , Davis Thomas P , Ronaldson Patrick T
Published: April 2017

Targeting uptake transporters such as organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood–brain barrier (BBB) can facilitate central nervous system (CNS) drug delivery. Effective blood-to-brain drug transport via this strategy requires characterization of mechanisms that modulate BBB transporter expression and/or activity. Here, we show that activation of activin receptor-like kinase (ALK)-1 using bone morphogenetic protein (BMP)-9 increases Oatp1a4 protein expression in rat brain microvessels in vivo. These data indicate that targeting ALK1 signaling with BMP-9 modulates BBB Oatp1a4 expression, presenting a unique opportunity to optimize drug delivery and improve pharmacotherapy for CNS diseases.
Antenatal dexamethasone before asphyxia promotes cystic neural injury in preterm fetal sheep by inducing hyperglycemia
Authors: Lear Christopher A , Davidson Joanne O , Mackay Georgia R , Drury Paul P , Galinsky Robert , Quaedackers Josine S , Gunn Alistair J , Bennet Laura
Published: April 2017

Antenatal glucocorticoid therapy significantly improves the short-term systemic outcomes of prematurely born infants, but there is limited information available on their impact on neurodevelopmental outcomes in at-risk preterm babies exposed to perinatal asphyxia. Preterm fetal sheep (0.7 of gestation) were exposed to a maternal injection of 12 mg dexamethasone or saline followed 4 h later by asphyxia induced by 25 min of complete umbilical cord occlusion. In a subsequent study, fetuses received titrated glucose infusions followed 4 h later by asphyxia to examine the hypothesis that hyperglycemia mediated the effects of dexamethasone. Post-mortems were performed 7 days after asphyxia for cerebral histology. Maternal dexamethasone before asphyxia was associated with severe, cystic brain injury compared to diffuse injury after saline injection, with increased numbers of seizures, worse recovery of brain activity, and increased arterial glucose levels before, during, and after asphyxia. Glucose infusions before asphyxia replicated these adverse outcomes, with a strong correlation between greater increases in glucose before asphyxia and greater neural injury. These findings strongly suggest that dexamethasone exposure and hyperglycemia can transform diffuse injury into cystic brain injury after asphyxia in preterm fetal sheep.
Comparative Effectiveness of Tacrolimus-Based Steroid Sparing versus Steroid Maintenance Regimens in Kidney Transplantation: Results from Discrete Event Simulation
Authors: Desai Vibha C. A. , Ferrand Yann , Cavanaugh Teresa M. , Kelton Christina M. L. , Caro J. Jaime , Goebel Jens , Heaton Pamela C.
Published: April 2017

Background. Corticosteroids used as immunosuppressants to prevent acute rejection (AR) and graft loss (GL) following kidney transplantation are associated with serious cardiovascular and other adverse events. Evidence from short-term randomized controlled trials suggests that many patients on a tacrolimus-based immunosuppressant regimen can withdraw from steroids without increased AR or GL risk. Objectives. To measure the long-term tradeoff between GL and adverse events for a heterogeneous-risk population and determine the optimal timing of steroid withdrawal. Methods. A discrete event simulation was developed including, as events, AR, GL, myocardial infarction (MI), stroke, cytomegalovirus, and new onset diabetes mellitus (NODM), among others. Data from the United States Renal Data System were used to estimate event-specific parametric regressions, which accounted for steroid-sparing regimen (avoidance, early 7-d withdrawal, 6-mo withdrawal, 12-mo withdrawal, and maintenance) as well as patients’ demographics, immunologic risks, and comorbidities. Regression-equation results were used to derive individual time-to-event Weibull distributions, used, in turn, to simulate the course of patients over 20 y. Results. Patients on steroid avoidance or an early-withdrawal regimen were more likely to experience AR (45.9% to 55.0% v. 33.6%, P < 0.05) and GL (51.5% to 68.8% v. 37.8%, P < 0.05) compared to patients on steroid maintenance. Patients in 6-mo and 12-mo steroid withdrawal groups were less likely to experience MI (11.1% v. 13.3%, P < 0.05), NODM (30.7% to 34.4% v. 37.7%, P < 0.05), and cardiac death (29.9% to 30.5% v. 32.4%, P < 0.05), compared to steroid maintenance. Conclusions. Strategies of 6- and 12-mo steroid withdrawal post-kidney transplantation are expected to reduce the rates of adverse cardiovascular events and other outcomes with no worsening of AR or GL rates compared with steroid maintenance.
Iron in deep brain nuclei in migraine? CAMERA follow-up MRI findings
Authors: Palm-Meinders Inge H , Koppen Hille , Terwindt Gisela M , Launer Lenore J , van Buchem Mark A , Ferrari Michel D , Kruit Mark C
Published: April 2017

Introduction

In the CAMERA population-based MRI study, migraineurs below the age of 50 had decreased T2-values indicative of increased iron deposition in several deep brain nuclei. Longer migraine history was associated with lower T2-values, suggesting an association between migraine attacks and iron accumulation. In the present nine-year follow-up study of the CAMERA cohort we re-measured the T2-values in deep brain nuclei to assess the evolution over time.

Methods

Baseline and follow-up T2-values measured in several basal ganglia of 128 participants (38 control, 90 migraine) were analyzed using quantitative T2 measurements and multivariate regression analysis.

Results

T2-values of most deep brain nuclei were increased – instead of an expected further decrease when only age-related iron accumulation would have played a role – compared to baseline (both among controls and migraineurs) and were not different in either group. In migraineurs, no differences were found by gender, migraine severity or subtype.

Conclusion

This study did not provide supportive data for migraine related increased iron accumulation in deep brain nuclei, but neither is it able to reject such hypotheses. Increased T2-values probably point at microstructural tissue changes that counteracted earlier accumulated iron effects. We hypothesize that, with aging, migraine-induced iron-related brain changes are obscured by other age-related tissue changes.
Notch sensitivity of short and 2D plain woven glass fibres reinforced with different polymer matrix composites
Authors: Elbadry Elsayed A , Abdalla GA , Aboraia M , Oraby EA
Published: April 2017

This research article investigated the notch sensitivity of two different glass fibre architectures, namely short and 2D plain-woven glass fibres reinforced with unsaturated polyester and epoxy matrix composites fabricated by the hand lay-up technique. This was carried out through open hole tension tests at different ratios of the specimen hole diameter to the specimen with three different values (0.1, 0.2, 0.5) compared to the unnotched specimen. The notch sensitivity of these composites was evaluated using the residual tensile strength by the application of Whitney–Nuismer Mathematical Model. The results showed that by using polyester matrix, the notch sensitivity of composites reinforced with plain-woven glass fibre is higher than that of short glass fibre at different D/W ratios. On the other hand, on testing epoxy matrixes, the notch sensitivity of composites reinforced with plain-woven glass fibre is lower than that of short glass fibre at different D/W ratios.
The Effectiveness of Alternative IEP Dispute Resolution Practices
Authors: Scanlon David , Saenz Lauren , Kelly Michael P.
Published: April 2017

Alternative Individualized Education Program (IEP) dispute resolution models should respond to limitations of current options. An experimental IEP dispute resolution program provides parents and schools with an evidence-supported neutral perspective on what is needed for free and appropriate education (FAPE) and least restrictive environment (LRE). Then, instead of being facilitated or directed via a hearing, for example, the parties attempt to resolve their own dispute. Ninety percent of consultations led to a signed IEP. Effectiveness, however, also concerns satisfaction and working relationships between the parties. Follow-up surveys with 36% of parent parties (parent, advocate, attorney), and 33% of school parties (administrator, educator, attorney) were analyzed using concurrent triangulation mixed methods design, including a content coding analysis. Results reveal beliefs by a majority that the process was effective, and working relationships were maintained or strengthened. Lessons for future interactions were learned.
Influence of Religion on Later Burden and Health of New Black and White Caregivers
Authors: Fider Carla R. A. , Lee Jerry W. , Gleason Peter C. , Jones Patricia
Published: April 2017

Objective: We assessed the relationship between positive aspects of religiosity and reduced stress in caregivers, and negative aspects of religiosity and increased caregiver burden. Method: Using data from the Biopsychosocial Religion and Health Study, we performed multiple linear regression analysis on 584 caregivers. Results: Mental health, but not physical health, was predicted by caregiver burden. Caregivers who viewed God as loving and not controlling and felt a sense of community with their church family had less burden. Caregivers who engaged in negative religious coping had a greater decline in mental health than those who saw God as loving and not controlling and who gave emotional support to others. Discussion: Some aspects of religion appear to play an important role in alleviating the mental stresses of being a caregiver.
Three Forms of Neurorealism: Explaining the Persistence of the “Uncritically Real” in Popular Neuroscience News
Authors: Gruber David R.
Published: April 2017

Neuro-realism is a widely cited concept describing a textual phenomenon in popular science news wherein brain research uncritically validates or invalidates the “realness” of particular beliefs or practices. Currently, no research on neuro-realism examines the variable rhetorical roles of such statements, that is, how they support specialized arguments or enhance social functions across genres of public communication. This article details the nuances of neuro-realism, arguing that neuro-realism is much more than a singular textual phenomenon but a flexible rhetorical vehicle manifesting in at least three forms: commonsense, judicial, and rational. Each form serves a larger argumentative purpose, and each can be consistently linked to a popular news subgenre, illuminating how neuro-realism’s stunning lack of criticality proves permissible and reproducible in popular science publications.
The Patients as Partners Movement and the emerging health leader
Authors: Young Melinda
Published: April 2017

Over the past decade, the Patients as Partners Movement has spread throughout healthcare systems across Canada. This movement aims to overcome the paternalistic approach, where the system and its providers act for or deliver services to the patient. Instead, decision-making at all levels is to be shared with the patient. Delivering patient- and family-centred care is the goal of the Patients as Partners Movement and authentic engagement is at its core. This article aims to explore the link between the Patients as Partners Movement and authentic engagement. It will then outline how senior leaders can capitalize on the mindset of emerging leaders and support their development through mentorship and encouraging skill-building in key competencies related to authentic engagement. Support in these areas by senior leaders is suggested to enable the retention and development of a powerful generation of health system leaders who view patients as their partners.
The ethics of genome editing in the clinic: A dose of realism for healthcare leaders
Authors: Bubela Tania , Mansour Yael , Nicol Dianne
Published: April 2017

Genome editing technologies promise therapeutic advances for genetic diseases. We discuss the ethical and societal issues raised by these technologies, including their use in preclinical research, their potential to address mutations in somatic cells, and their potential to make germ line alterations that may be passed to subsequent generations. We call for a proportionate response from health leaders based on a realistic assessment of benefits, risks, and timelines for clinical translation.