bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of genetic variants in the solute carrier (SLC) genes encoding drug uptake transporters on the response to anticancer chemotherapy
Authors: Marin Jose J. G. , Serrano Maria A. , Herraez Elisa , Lozano Elisa , Ortiz-Rivero Sara , Perez-Silva Laura , Reviejo Maria , Briz Oscar
Published: July 2024

Cancer drug resistance constitutes a severe limitation for the satisfactory outcome of these patients. This is a complex problem due to the co-existence in cancer cells of multiple and synergistic mechanisms of chemoresistance (MOC). These mechanisms are accounted for by the expression of a set of genes included in the so-called resistome, whose effectiveness often leads to a lack of response to pharmacological treatment. Additionally, genetic variants affecting these genes further increase the complexity of the question. This review focuses on a set of genes encoding members of the transportome involved in drug uptake, which have been classified into the MOC-1A subgroup of the resistome. These proteins belong to the solute carrier (SLC) superfamily. More precisely, we have considered here several members of families SLC2, SLC7, SLC19, SLC22, SLCO, SLC28, SLC29, SLC31, SLC46, and SLC47 due to the impact of their expression and genetic variants in anticancer drug uptake by tumor cells or, in some cases, general bioavailability. Changes in their expression levels and the appearance of genetic variants can contribute to the Darwinian selection of more resistant clones and, hence, to the development of a more malignant phenotype. Accordingly, to address this issue in future personalized medicine, it is necessary to characterize both changes in resistome genes that can affect their function. It is also essential to consider the time-dependent dimension of these features, as the genetic expression and the appearance of genetic variants can change during tumor progression and in response to treatment.
Getteng dalam Paseng Pangaderreng Masyarakat Bugis sebagai Basis Pengembangan Pendidikan Karakter di Sekolah Dasar
Authors: Sayidiman Sayidiman , Manggau Arifin , Ramli Asia , Hermuttaqien Bhakti Prima Findiga
Published: July 2024

Penelitian ini didasari adanya problem moral di kalangan peserta didik yang mengindikasikan adanya krisis dalam sistem pendidikan kita. Solusi yang diusulkan adalah pendidikan karakter berbasis kearifan lokal. Penelitian ini bertujuan untuk mengkaji potensi nilai-nilai kearifan lokal Bugis, "Paseng Pangngaderreng, sebagai basis pengembangan pendidikan karakter di sekolah dasar. Metode penelitian menggunakan kualitatif dengan pendekatan etnografi. Teknik pengumpulan data melalui wawancara, observasi, dan dokumentasi. Teknik analisis data menggunakan analisis domain, analisis komponensial, analisis taksonomi dan analisis tema kultural. Hasil penelitian menunjukkan terdapat 4 rincian domain sebagai klausul utama dalam prinsip getteng dan memuat nilai moral utama yakni kejujuran dan integritas, terdapat 3 rincian domain sebagai bentuk pesan kepada pemimpin dengan nilai moral keutamaan kebijaksanaan, pengertian, empati, pengendalian diri dan pencarian kebenaran. Berdasarkan hasil analisis tema kultural ditemukan bahwa kehadiran getteng menjadi bagian penting dalam kehidupan masyarakat bugis, nilai getteng dan Paseng Pangngaderreng tidak hanya memiliki relevansi budaya tetapi juga aplikatif dalam konteks kehidupan modern masyarakat Bugis, dan berdasarkan analisis taksonomi ditemukan bahwa nilai getteng diterapkan dalam dua konteks utama yakni kehidupan sehari-hari dan kepemimpinan.
Detailed Investigation of Dolomites in the Middle Jurassic Samana Suk Formation, Kahi Section, Nizampur Basin, North-Western Himalayas (Pakistan)
Authors: Kamal A. , Shah M.M. , Rahim H.U. , Zafar T. , Khalil R. , Shahzeb M.
Published: July 2024

—Diagenetically modified carbonate rocks are more common in the rock record. Among these modifications, multiphase dolomitization is the most common process. The Middle Jurassic carbonates of the Samana Suk Formation are extensively altered by the dolomitization process in the Kahi section, Nizampur Basin. The primary objective of this study is to investigate this multiphase dolomitization and to elucidate its possible mechanism.

Field investigation shows both host limestone (oolitic, fossiliferous, and massive) and dolomites. Dolomite bodies are of both beddings: parallel to and crosscutting the bedding planes. Different types of dolomites were recognized on the basis of color contrast as dark gray replacive dolomite, light gray dolomite, brownish dolomite, and yellowish dolomite. Along with the replacive phase, void- and fracture-filling cementing saddle dolomite and cementing calcites are recognized in the field. Petrographic studies show the complex diagenetic history of the Samana Suk Formation from near-surface diagenesis, including micritization, neomorphism, and several varieties of dolomites. These varieties are as follows: RD1 is very fine- to fine-grained dolomite; RD2 is medium- to coarse-grained and anhedral to subhedral dolomite; RD3 is coarse- to very coarse-grained and planar euhedral zoned dolomite; and RD4 is coarse-grained euhedral to subhedral ferroan dolomite. In addition, cementing saddle dolomite SD consists of large crystals with curved faces showing sweeping extinction. Cementing calcite phases are as follows: CC1 is granular mosaic; CC2 is twin; CC3 is fracture-filling; and CC4 is ferroan calcite. The stable isotope values of limestone (δ18O is –7.13 to –0.73‰ V-PDB, and δ13C is –0.05 to 1.32‰ V-PDB) show depletion with respect to the Jurassic marine signature. The values of multiphase dolomites RD1–RD4 and SD (δ18O is –8.65 to –3.16‰, and δ13C is –3.56 to 2.09‰) indicate multiphase dolomitization. The CC1–CC3 values (δ18O is –11.07 to –8.97‰, and δ13C is –2.14 to 0.76‰) indicate highly depleted values of δ18O, showing hydrothermal origin. From field, petrography, and geochemistry data, it is deduced that a possible source of Mg for hydrothermal dolomites is activation of faults and fractures during active tectonic regime in the area and might be related to activation and reactivation of the Kahi Thrust system.
Song of the Great Dao of the Spiritualized Source: Preliminary Study
Authors: Belaya Irina ,   Institute of Oriental Studies of the Russian Academy of Sciences,   Institute of China and Contemporary Asia, Russian Academy of Sciences
Published: July 2024

The article is devoted to the study of the Song of the Great Dao of the Spiritualized Source (Ling yuan da dao ge). This is a work on Daoist “inner alchemy”, which describes the process of transforming the spirit and the breath in poetic form. The author of Ling yuan da dao ge was the Daoist nun and poetess Cao Wen-yi (1039–1115). Cao Wen-yi is the only woman-philosopher who wrote a commentary on the Dao De jing, which has survived to this day in the Daoist Canon (Dao zang). Her talents were highly appreciated by Emperor Huizong, who granted her the title “Excellent in Literary Talent” (Wen-yi zhen-ren). The goal of the study is to highlight the most important ideological and theoretical components of the Song of the Great Dao of the Spiritualized Source. As a result of the study, the cultural and historical environment of this work was reconstructed, its earlier list written in prose was identified, the dating of the full version of Ling yuan da dao ge was clarified, and its content features were revealed. The main task of the Song of the Great Dao of the Spiritualized Source is to explain the principle of simultaneous improvement of inner nature and vitality (xing ming shuang xiu). This principle became the main vector of development of Daoist psychophysiological methods, starting from the Song era. Improving the inner nature, according to Cao Wen-yi, is achieved by detaching the heart from feelings and desires. This state is called “no heart” (wu xin) and is the “true heart of the Dao”. Improving vitality is achieved through breathing exercises, which should be based on the principles of suchness (zi ran) and non-action (wu wei).
Open Rationality: A Quarter of a Century Later (To the 90th Anniversary of Vladimir Schvyrev)
Authors: Porus Vladimir ,   National Research University Higher School of Economics
Published: July 2024

The article analyses the contribution of professor V.S. Shvyrev (1934–2008) in the development of the theory of rationality. In the 1970s–80s, he introduced the concept of “open rationality” into the thesaurus of domestic epistemological research, critically starting from the idea of rationality as a compliance with a fixed set of unchanging criteria (“closed rationality”). The “closedness” of ra­tionality is associated with the theological and metaphysical origins of classical rationalism, the crisis of which in the modern world has become obvious. Absol­utization of “closedness” leads to dogmatism, which inhibits development. This applies not only to scientific knowledge, but also to all forms of social life, men­tal and practical activity. Openness of rationality is the result of critical reflection in relation to these criteria, creating the possibility of changing their system. Critical reflection is the cause and, at the same time, a necessary consequence of rationality, the driving force for the development of knowledge and social sys­tems. “Closed” and “open” rationality are related in meaning and are mutually definable concepts that make up “complementarity” (in the spirit of N. Bohr’s methodological principle). Rationality is not only a methodological principle but also a cultural value. Тherefore, its “openness” problematizes the development of culture. In this regard, critical reflection plays the role of a filter that protects against replacing the criteria of rationality with value judgments expressing vari­ous private interests. Such an approach to the problem of rationality, outlined in the works of V.S. Shvyrev, opens up the prospect of cultural-historical episte­mology, which connects logic and methodology, history and philosophy of cul­ture, philosophy of knowledge. This connection allows for a multilevel epi­stemological interpretation of special scientific (historical, sociological, and psychological) data on developing knowledge and social systems.
What the Human Mind Is for: the Evolution of the Unconscious (Theses on the General Theory of Evolution)
Authors: Givishvili Givi ,   Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation (IZMIRAN), Russian Academy of Sciences
Published: July 2024

Revolutionary experiments in space, carried out in the XXI century, proved the physical non-existence of space and time. Infinitely extended space is also uniformly filled with boundless matter in the form of discrete clusters of mass-energy. Time, on the other hand, turns out to be a fixation of the sequence and duration of cause-and-effect relationships in any process occurring in and be­tween material objects. Therefore, nature is dualistic: it exists in the form of two conditionally independent principles – non-existence (non-existent space-time continuum) and being (the existing material-ideal Cosmos). At the same time, the physical existence of matter is unthinkable without the physical non-exis­tence of space-time. The Cosmos is also dualistic, dividing into two interdepen­dent objects: a) the transitory material (mass-energy) and the imperishable ideal (laws, principles and algorithms of the existence of matter); b) the countless discrete mass-energy dynamic Small Universes (galaxies and their clusters). Together they make up one stationary Large Universe, unlimited in mass and en­ergy. At the same time, the material and the ideal together form four intercon­nected steps of the pyramid of the Cosmos: a) the world of elementary particles; b) the world of galaxies, stars and planets; c) the sphere of organics; d) the sphere of culture. Accordingly, a human-like mind turns out to be a categorically impe­rative element of the Cosmos. This conclusion follows from the fact of the limi­ted duration of the active phase of the existence of Small Universes. The lat­ter circumstance is associated with an irreversible deterioration in the quality of the energy of stars and the extinction of their life cycle. However, currently physics does not know any natural process capable of regenerating the mass- energy of aging stars and reviving their activity. Consequently, for the artificial resumption of the vital activity of Small Universes, in fact, to maintain the eter­nal existence of the Large Universe, a human-like mind is needed (a super-strong anthropic principle). Thus, there is a need to rethink the phenomenon of evo­lution as a global process that encompasses the specifics of the interconnected existence of all four “horizons” of Nature.
Marx’s Theory and the Realities of World and Russian History
Authors: Momdzhyan Karen ,   Lomonosov Moscow State University
Published: July 2024

During the post-Soviet period of Russian history, a negative attitude towards Karl Marx was established in public opinion, who is considered the author of an eschatological utopia, the bankruptcy of which is considered self-evident proof of the scientific failure of the “materialistic understanding of history”. Ob­jecting to this point of view, the author examines the basic concepts of Marx’s philosophical and sociological doctrine, which (provided they are correctly un­derstood and rejected from unlawful absolutization) remain valid for modern sci­ence. At the same time, the author examines Marx’s ideas, which are not con­firmed by the course of modern history, which primarily include the German thinker’s ideas about the state and fate of modern capitalism. The author believes that the undoubted mistake of Marx, who mistook the birth pangs of civilized capitalism for its agony, should not be used to discredit the formational typology of history and Marx’s ideas about the socialist perspective of development. To prove this idea, it is important to understand that Marx is not responsible for the social system created by the Bolshevik revolution in Russia, which was not related to the socialist organization of society, representing the reincarnation of the political orders established in a European country on an industrial rather than agricultural basis. The natural collapse of this society was realized in full accordance with the postulates of the materialistic understanding of history and cannot be used as an argument in favor of their scientific failure.
The Classic of Non-Classical Epistemology: Reflections on the Book “Constructivism, Realism, Human. On the 90th Anniversary of V.A. Lektorsky”
Authors: Griftsova Irina ,   Institute of Social and Humanitarian Education, Moscow State Pedagogical University (MPGU), Knyazev Victor ,   Moscow State Pedagogical University
Published: July 2024

Contemporary epistemology faces a choice today: either to follow the path of the analytical tradition and refine the conceptual toolkit itself, or to redirect efforts towards the search for the “cognitive primordial”. Renowned Russian philosopher-epistemologist, academic Vladislav Aleksandrovich Lektorsky, who devoted his life to studying the most important problems of epistemology (sub­ject-object relationship, activity approach, classical and non-classical epistemo­logy, historical and collective memory, consciousness and self-awareness, arti­ficial intelligence, and the consequences of digitalization), proposed his vision of the future of gnoseological research. His concept of “constructive realism” has received wide discussion in the texts of Russian and foreign colleagues, friends, and students (humanitarian scholars and philosophers), presented in a col­lective monograph dedicated to his 90th anniversary. In the center of their atten­tion is the living cognizing human in the complex configuration of social, moral, epistemological, axiological, and ecological problems of modern digital civiliza­tion. The personal qualities of V.A. Lektorsky have always manifested them­selves in creating an atmosphere of freedom of research and creativity, collective discussion and philosophical criticism, friendliness and charm, pedagogical men­torship, and sensitive support for young researchers. The article demonstrates the relevance of the concept of “constructive realism” and its methodological ef­fectiveness in solving contemporary problems of philosophy, natural science, and social-humanitarian science in the context of the cultural-historical self-awareness of philosophers and scientists who responded to the anniversary of the classic of non-classical epistemology.
The Renaissance of Cooperation: the Search for Economic Rationality and Socio-spiritual Meanings
Authors: Frolova Elena ,   Financial University under the Government of the Russian Federation, Rogach Olga ,   Financial University under the Government of the Russian Federation
Published: July 2024

The article is devoted to the philosophical understanding of the phenomenon of cooperation, its role in achieving a new quality of being. The authors con­sider the current stage of development of society as a period of formation of conditions for the renaissance of cooperative forms of management, the re­vival of the ideas of cooperation and the collective spirit. The integrative func­tions of cooperation, its functional roles in the process of opposition to social entropy and disorganization are singled out. The authors come to the conclu­sion about the dual nature of cooperation, the ambivalence of the goals of co­operative practices, located on a continuum between economic rationality, satisfaction of reasonable selfish needs and transcendental meanings of harmo­nization of social life. The conclusion is substantiated that the imbalance be­tween the socio-spiritual and economic principles of cooperation becomes a source of dysfunctions, inversion of cooperative models. The following risks of the implementation of cooperative initiatives in the conditions of absolutiza­tion of the values of success are determined: destructive practices of ignoring collective interests, prioritization of personal gain, violation of ethical norms, contractual obligations. The article analyzes the influence of labor traditions, norms and national cultural code on the formation of cooperative forms of management.
Professional Ethics of the Fundamental Level and “New Ethics” of the Technological Type: Reality and Proper Prospects
Authors: Artemov Vyacheslav ,   Kutafin Moscow State Law University
Published: July 2024

One of the paradoxes of the present time is the catastrophic gap between the ex­traordinary complexity of the new problems and challenges that have befallen us all, on the one hand, and the conspicuous primitivism and outright professio­nalism of many of those who are one way or another obliged to react to what is happening. At the same time, the obvious inadequacy of such a situation at the professional level often simply not only does not receive proper critical as­sessment from society and the state, but is even accepted as acceptable. In this regard, in a certain sense, classical examples of critical speech and truly creative work can again become salutary: the moral and philosophical asceticism of So­crates, L.N. Tolstoy, A. Schweitzer, A.A. Zinoviev. The sociocultural task of en­suring a truly fundamental level of professional ethics is substantiated. We are talking about complex types of activities, in relation to which “new ethics” often only decorate the façade of all sorts of dubious technologies used momentarily, without proper examination of the possible consequences and the cultivation of morality (goodness). For most people, forced to play by new rules on the so­cio-economic field, digital disruption in a certain sense means a trap. The phe­nomenon of imitation of professionalism is analyzed when one is limited to ex­ternal effects, forgetting (or not wanting to know) about the socially assigned mission. The latter is called upon to be countered by moral philosophy as the ba­sis of ethical expertise. The article positions not only the methodological tools, but also the motivation of the experts themselves, including lawyers, who must have the appropriate ethical and philosophical education, to consistently carry out analytical and evaluative work from the standpoint of moving towards the ideal.
Dampak Industri Tepung Tapioka Terhadap Kesejahteraan Masyarakat Desa Tajug Kabupaten Ponorogo
Authors: Munawaroh Aflah Binti , Said Abadi
Published: July 2024

This study aims to analyze the social impact of the tapioca flour industry on society from an Islamic economic perspective and to analyze the economic impact of the tapioca flour industry on society from an Islamic economic perspective. The problem in this study is the problem of economic and social impacts which are problematic in the community environment that affect the community, these impacts are in the form of beneficial and detrimental impacts felt by the community to achieve the level of benefit, so this research will discuss how the economic and social impacts tapioca flour industry to society from an Islamic economic perspective. The type of research used is using qualitative research methods with a descriptive analysis approach. Data collection techniques using observation techniques, interviews and documentation. While the subjects of the study were the people affected by the tapioca flour industry in Tajug Village, Siman District, Ponorogo Regency. Based on the results of the study, it can be concluded that the social impact of the tapioca flour industry on the community can be seen from the indicators of education, health, housing or housing facilities and peace are in a condition that does not show benefit, because there are negative impacts on society on health and peace indicators, namely air pollution and many Mosquitoes are disturbing health, roads are damaged, many vehicles are milling about and complaining because the nature of this industry is seasonal, so it disturbs people's comfort. Meanwhile, the economic impact of the tapioca flour industry on the community can be seen from the indicators of income, poverty and employment, it can be said that this industry benefits the community because all indicators are fulfilled and can help the community's economy.
Pengaruh Pengalaman Dan Kepuasan Terhadap Loyalitas Pelanggan Di Mie Gacoan Ponorogo
Authors: Amalia Rizka , Maulida Nurhidayati
Published: July 2024

This study aims to test and determine the effect of experience and satisfaction on customer loyalty in Ponorogo gacoan noodles partially or simultaneously. This study uses a quantitative research design. In this study researchers used a questionnaire in collecting data. Meanwhile, to find out the number of samples, the researchers used the Cochran formula calculation and used incidental sampling techniques. In processing and analyzing data, researchers used the classical assumption test, multiple linear regression test, R^2 test, and hypothesis testing (t test and F test). The results of this study indicate that customer experience has a significant effect on customer loyalty at Mie Gacoan Ponorogo, customer satisfaction has a significant effect on customer loyalty at Mie Gacoan Ponorogo and simultaneously customer experience, and customer satisfaction has a significant effect on loyalty at Mie Gacoan Ponorogo. The magnitude of the influence exerted by the variables of customer experience and customer satisfaction on customer loyalty is 53.4%.
Employee Recruitment At Maesa Ponorogo Hotel Islamic Economic Perspective
Authors: Ahmad Ismi Muhaimin  , Fitra Rizal
Published: July 2024

Introduction: Recruitment is essential in human resource management because it is the first step in finding suitable employees to fill vacant positions. Managers are responsible for managing human resources, so a fair attitude is vital. Good recruitment can increase a positive image and profits for the company. This research aims to analyze the implementation and impact of employee recruitment at the Maesa Ponorogo Hotel from an Islamic economic perspective. Research Methods: The type of research used by researchers is field research, while the method used in this research is qualitative. Results: This research shows that Hotel Maesa Ponorogo places integrity and fairness as a top priority by Islamic recruitment principles so that every candidate has an equal opportunity to be assessed based on their qualifications and potential. This process affects the quality of service to customers and creates a productive and harmonious work environment for employees. Thus, Hotel Maesa Ponorogo's employee recruitment policy reflects their commitment to providing high-quality services, which strengthens the company's positive image and increases overall customer satisfaction, contributing to increased profits for Hotel Maesa.
Pengaruh Lingkungan Kerja Dan Stres Kerja Terhadap Loyalitas Karyawan PT Sinar Asia Fortuna Di Rembang
Authors: Linawati Linawati , Yunaita Rahmawati
Published: July 2024

This research aims to determine and analyze the influence of the work environment and work stress on employee loyalty at PT Sinar Asia Fortuna in Rembang, both partially and simultaneously. The type of research used is quantitative research. In collecting data, researchers used a questionnaire distributed to permanent employees. Meanwhile, the sample in this study was obtained from a purposive sampling technique. As for data processing and analyzing data, researchers used the classic assumption test method, multiple linear regression test, t-test, and F test. The study results showed that work environment significantly affects employee loyalty at PT Sinar Asia Fortuna in Rembang, and work stress significantly affects loyalty at PT Sinar Asia Fortuna in Rembang. Simultaneously, work environment and work stress have a significant effect on the loyalty of PT Sinar Asia Fortuna the goodness of fit from modeling of the work environment and work stress on employee loyalty is 44.8%, and other variables influence the rest.
Decision in Shopping In the Charity of an Islamic Community Organization
Authors: Azis Mansur , Said Abadi  , Faisa Nurdiantini
Published: July 2024

A purchasing decision is a process of making choices by integrating knowledge used to combine knowledge and evaluating two or more alternatives. Strategy is the primary key to survival and growth; besides that, consumers are also the most critical assets for a company's survival. If a company can meet or satisfy the desires of consumers, it will get loyalty from its consumers; the company is legally obliged to study marketing strategies to influence consumers to decide to buy; the purpose of this research is to identify and analyze the influence and marketing (product, price, place, promotion, people, process, and physical evidence) applied by Surya Mart and Nusantara Mart Rationally and simultaneously on consumer decisions, l. The method used in this study is Quantitative, linear regression. The results of this study are 1) from the results of the quantitative test, the product sig value is 0.00, price 0.00, promotion 0.00, people 0.01, process 0.00, physical evidence 0.00, all of which are <0.05, which means that six marketing strategies have a significant effect on consumer decisions and only one is less effective in influencing place<0.05. Meanwhile, the simultaneous test results were 0.00<0.05, which means that marketing strategies (marketing (products, prices, places, promotions, people, processes, and physical evidence) simultaneously positively affect consumer decisions.
Dampak S-Pay Later Terhadap Konsumen Muslim: Perspektif Keuangan Islami
Authors: Hanik Fitriani
Published: July 2024

Using the S-Pay Later digital-based payment system in the Shopee marketplace will likely make things easier for its users. Its use increases every year.  This can be seen from the Financial Services Authority (OJK) records. In March 2024, debt to S-Paylater reached IDR 6.13 trillion, an increase of 2.90% from March 2023. As a Muslim consumer, it is essential to consider S-Paylater services based on perspective. Islamic finance is based on Sharia law, which contains elements of the prohibition of usury (interest), gharar (transactions must not contain elements of excessive speculation), which harm one party, may (gambling), and fairness. This research uses a qualitative descriptive method, namely by collecting literature studies, namely taking scientific references from books, journals, and other references as well as previous research that suits the researcher's problems; then, the data obtained will be analyzed to conclude. The results of this research are that the impact of S-Paylater on Muslim consumers is divided into two, namely the positive impact, including ease of accessibility and improvement of lifestyle; the negative impact is the potential for being trapped in debt, the potential for waste, compliance with sharia is still doubtful because there is an element of usury and the existence of financial entanglement.
Plataformas de prototipagem de hardware para uso em disciplinas com aprendizagem baseada em projetos
Authors: Santana Farias Marcos , Almeida Wong Gustavo , Dutra Gonzaga Jaime Guilherme
Published: July 2024

Este artigo aborda o desenvolvimento de plataformas de prototipagem de hardware, especificamente projetadas para otimizar o aprendizado em disciplinas que empregam a Aprendizagem Baseada em Projetos (ABP) nas áreas de ciência da computação e engenharia. As plataformas desenvolvidas se concentram em tecnologias como ESP32, PIC e FPGA, e integram uma variedade de sensores e componentes auxiliares. Esse arranjo proporciona aos alunos um ambiente prático e interativo para que possam explorar, aprender e inovar. O projeto atravessou várias etapas, abrangendo pesquisa com professores e seleção de componentes, desenvolvimento de esquemas elétricos, criação de PCI e modelos 3D das placas, além da elaboração de documentação extensiva e materiais de treinamento, com destaque para o GitHub das aplicações. A uniformidade na seleção de componentes em diferentes plataformas visa promover uma aprendizagem integrada e coesa, facilitando a transição entre diferentes tecnologias e contextos de aplicação. As possíveis aplicações de teste para as plataformas são incluídas, abrangendo áreas como monitoramento ambiental, robótica, automação e criptografia, bem como a implementação de códigos de exemplo e a integração de protocolos de comunicação bem estabelecidos, a exemplo de HTTP e MQT. O projeto descrito ressalta a importância dessas plataformas no fortalecimento do aprendizado prático e teórico, na promoção da inovação e criatividade e na preparação de futuros profissionais para enfrentar desafios em um mundo tecnologicamente avançado e em constante evolução.
Grupo de Estudos em Abelhas (GEA-IFC):
Authors: Ribeiro Tiago , Arboitte Miguelangelo Ziegler , Assola Glória , Spido Vanessa , Furlanetto Karina , Pereira Érica , De Almeida Emerson , Machado Letícia
Published: July 2024

A atividade com abelhas é extremamente complexa, necessitando apoio institucional para a sua execução e dedicação dos participantes. As ações de extensão com captura de enxames solicitados pela comunidade, execução de cursos, palestras, participação em eventos, pesquisas publicadas em resumos de eventos de nível nacional e internacional, parcerias com órgãos públicos e privados, demandas por inovação na área de apicultura e meliponicultura. Para a execução das ações foi necessário muito empenho dos participantes e colaboração de outras pessoas ligadas direta ou indiretamente ao projeto. As ações atenderam grande público, não apenas os do entorno do IFC Santa Rosa do Sul, mas também outras localidades fora do estado de Santa Catarina e do Brasil, nas apresentações de trabalhos em Congressos internacionais, levando o nome do IFC. Parcerias e demandas foram geradas de pesquisas, de extensão, de ensino e inovação sempre estarão no foco do GEA, e a continuidade das ações vão acontecendo naturalmente, sendo atendidas dentro das possibilidades e do alcance do grupo de estudo em abelhas.
Monitoramento de esporos da ferrugem asiática da soja no Planalto Norte Catarinense – safra 2023/2024
Authors: Tschoeke Steidel Otávio Frederico , Souza Farias Eduardo Virmond , Stolte Henrique , Vieira Luis Carlos , Melo Pereira Laís Fernanda , Noernberg Donato João , Würz Douglas André
Published: July 2024

O monitoramento de esporos da ferrugem asiática da soja torna-se de grande relevância na identificação do patógeno antes da visualização dos sintomas da doença, pois quando são observados os sintomas no campo, é sinal de que a ferrugem já está instalada, e o uso de fungicidas pode ser prejudicado. Dado a importância do monitoramento da presença de esporos do fungo Phakopsora pachyrhizi para o manejo da doença, esse trabalho tem como objetivo realizar relato de ação de extensão realizado na região do Planalto Norte Catarinense, no monitoramento da ferrugem asiática da soja. Para a safra 2023/2024, na região do Planalto Norte Catarinense, as leituras das lâminas ocorrem no IFSC – Campus Canoinhas, com auxílio dos estudantes do Curso de Agronomia. As leituras são realizadas visualmente em microscópio óptico, por meio de varredura da fita adesiva, verificando a presença ou ausência de esporos. Na região do Planalto Norte Catarinense há oito coletores instalados: dois em Mafra, dois em Canoinhas, um em Itaiópolis, um em Major Vieira, um em Irineópolis e um em Bela Vista do Toldo. A troca de lâminas é realizada no período mínimo de uma vez por semana, pelos extensionistas da EPAGRI e pelos estudantes do Curso de Agronomia. É de grande relevância parcerias entre instituições de ensino, pesquisa e extensão, que através destas ações contribuem diretamente com o setor agropecuário catarinense, sendo estas ações indispensáveis no Manejo Integrado da Ferrugem Asiática da soja, permitindo manejo sustentável e econômico.
Multistep-Ahead Prediction of Logging-While-Drilling Resistivity Curves Based on Seismic-Guided Seq2Seq-Long Short-Term Memory
Authors: Zhang Lingyuan , Zhang Hongbing , Zhu Xinyi , Zeng Fanxin , Yan Lizhi
Published: July 2024

High-temperature and high-pressure reservoirs in complex geological conditions present primary targets and significant challenges in deepsea oil and gas exploration. Limited offshore drilling operations and lack of detailed geological data hinder accurate formation pressure prediction using geoguided and offset imaging, increasing drilling hazards. Logging-while-drilling (LWD) technology provides timely and accurate subsurface information. Resistivity closely correlates with formation pressure and lithology, aiding pressure prediction. Therefore, in this study, we developed an ahead prediction workflow for LWD curves using the resistivity curve (RD) as an example. A seismic-guided sequence-to-sequence framework with the long short-term memory model (Seq2Seq-LSTM) is used to predict the RD curve at a constant depth ahead of the drill bit, utilizing the RD curve of drilled sections and seismic attributes. The network structure incorporates a direct-recursive hybrid multistep prediction strategy based on update threshold control (Dir-Rec-Update), aligning with real-time LWD data acquisition for ahead curve prediction. Using real well data cross-prediction, baseline models such as multilayer perceptron (MLP) and extreme gradient boosting (XGBoost) were compared while also investigating the impact of different configurations on the proposed Seq2Seq-LSTM. The results demonstrate that the method outperforms conventional models, with an average performance across multiple wells under a 5-m update threshold: root mean square error (RMSE) of 0.15, correlation coefficient of 0.88, and coefficient of determination of 0.77. The Seq2Seq-LSTM model and Dir-Rec-Update strategy provide accurate LWD curves ahead of the drill bit, enabling advanced drilling decisions and preventing hazards. Advanced technologies such as empirical wavelet transform (EWT) and feature selection enhance the method’s potential for curve ahead-of-time prediction.
Anemoside B4 alleviates DSS-induced colitis by inhibiting CD1d-dependent NLRP3 inflammasome activation in macrophages
Authors: Zhang Qinggao , li jiao , Li Pan , Yuan Shuo , Xue Jiachen , Meng Huan , Hou Xiaoting , Gao Bihu
Published: July 2024

Abnormal activation of the NLRP3 inflammasome in macrophages is closely associated with Ulcerative colitis (UC) and targeting the NLRP3 inflammasome has been proposed as a potential therapeutic approach, but the underlying mechanism by which it regulates intestinal inflammation remains unclear. Anemoside B4 (AB4) has anti-inflammatory activity, but whether it alleviates UC by inhibiting the activation of NLRP3 inflammasome remains unclear. More importantly, the molecular targets of AB4 remain unknown. Our study showed that AB4 had a strong anti-inflammatory effect dextran sodium sulfate (DSS)-induced colitis in WT mice, whereas the protective effects were lost in NLRP3-/-mice. Interestingly, AB4 inhibited the activation of NLRP3 inflammasome in colonic macrophages without affecting intestinal epithelial cells. Mechanistically, AB4 might target CD1d thus reducing the AKT-STAT1-PRDX1-NF-κB signaling pathway, eventually inhibiting the activation of NLRP3 inflammasome. Macrophage-specific CD1d depletion had been shown to reverse the protective effect of AB4. Therefore, as a natural product with high safety index, AB4 might be considered a promising candidate drug for the treatment of colitis.
Diagnostic values of different ultrasonic parameters related to optic nerve sheath for the increased intracranial pressure in patients with brain injury: an observational study
Authors: Xu Xiaolan , Xu Qun , Lu Yajing , Tao Anyu , Liu Yani , Deng Youbin , Guo yinping
Published: July 2024

Background
Many studies have suggested that the optic nerve sheath diameter (ONSD) measured by transorbital ultrasound could reflect the increased intracranial pressure (ICP). However, whether the optic nerve subarachnoid space width (ONSASW) could evaluate the increased ICP, and whether it has better diagnostic value for the increased ICP than ONSD are lack of knowledges.
Methods
Patients with brain injury undergoing ICP monitoring after external ventricular drainage surgery were enrolled. Within 48 hours post-surgery, ONSDI/ONSDE (ONSD including/excluding the dura mater) and OND (optic nerve diameter) were measured via transorbital ultrasound at 3mm behind the retina. The ONSASW was defined as the difference between ONSDI/ONSDE and OND (i.e., ONSDI-OND/ONSDE-OND). Patients were categorized into increased ICP and normal ICP groups based on invasive ICP measurements. The differences of the ONSASW between the two groups were compared, and ROC curve analysis was used to assess its diagnostic value for increased ICP.
Results
A total of 70 patients (including 17 patients with increased ICP and 53 patients with normal ICP) were ultimately included in the study. Significant differences were observed in ONSDI, ONSDI-OND, and ONSDE-OND between the increased and normal ICP groups (all p < 0.05). Additionally, it was determined that ONSDI, ONSDI-OND, and ONSDE-OND exhibited diagnostic value for increased ICP (all p < 0.001), with ONSDI-OND demonstrating superior performance with an area under the curve (AUC) of 0.806.
Conclusions
The ONSASW (especially defined as ONSDI-OND) is not only associated with increased ICP, but also possesses superior diagnostic value for increased ICP in brain-injured patients compared to ONSD.
A new clinical classification of congenital biliary dilatation HUAXI CBD classification
Authors: Xie Zhenyu , Pu Siyu , Jin Shuguang , Xiang Bo , Yang Jiayin , Yan Lvnan
Published: July 2024

Objective
To propose a more concise and more suitable classification of congenital biliary dilatation (CBD), and exploring the feasibility and effectiveness of this classification in diagnosis and treatment.
Methods
Based on the preoperative imaging data of patients with CBD admitted to the Department of Pediatric Surgery of West China Hospital of Sichuan University, from January 2015 to December 2018, a new classification of CBD was accomplished according to the site of bile duct dilatation lesions, which was named HUAXI CBD classification. The CBD was classified into 4 types: type Ⅰ (distal extra-hepatic bile duct dilatation), type Ⅱ (distal extra-hepatic combined with right and left primary hepatic bile duct dilatation), type Ⅲ (extra-hepatic combined with secondary and above hepatic bile duct dilatation), and type Ⅳ (intra-hepatic bile duct dilatation). Meanwhile, the feasibility and reliability of the HUAXI CBD classification were analyzed by analyzing the clinical treatment strategies, perioperative complications and long-term follow-up results of different subtypes.
Results
A total of 300 patients with CBD were included in this study. According to the HUAXI CBD classification method, 240 cases were type Ⅰ, 48 cases were type Ⅱ, 10 cases were type Ⅲ, and 2 cases were type Ⅳ. For type Ⅰ, 236 patients underwent cholecystectomy and Roux-en-Y hepaticojejunostomy and 4 cases were treated non-operatively; For type Ⅱ, 48 patients underwent cholecystectomy, central hepatic duct reconstruction and Roux-en-Y hepaticojejunostomy; For type Ⅲ, 9 patients underwent cholecystectomy and Roux-en-Y hepaticojejunostomy, 5 of which had intrahepatic dilatation confined to part of the liver lobe and underwent partial hepatectomy with intra-hepaticojejunostomy. One case was treated with percutaneous transhepatic cholangial drainage (PTCD) only; two type Ⅳ patients were treated with PTCD only. Patients with type Ⅰ had a normal hepatobiliary function after surgery and a good prognosis; patients with type Ⅱ had good recovery of liver function in 37 cases (77.1%), but 11 cases (22.9%) had postoperative complications during follow-up; patients with type Ⅲ and Ⅳ had high incidence of cholangitis (6/10, 2/2, respectively) and choledocholithiasis (5/10, 2/2, respectively) after surgery, especially those with diffuse intrahepatic dilatation having a poor prognosis, eventually developing cirrhosis and necessitating liver transplantation.
Conclusions
The HUAXI CBD classification is consistent with treatment principles, concise and easy to remember, and more suitable for CBD clinical application.
Elevated serum gamma-glutamyl transferase level as a predictor of mortality in patients with anti-MDA5 antibody-positive dermatomyositis
Authors: Hu Wenlu , Zhang Panpan , Ding Yanxia , Dong Fang , Li Tianqi , Yang Lu , Liu Lijun , Zhang Lijuan , Li Tianfang , Liu Shengyun , Zhang Yusheng
Published: July 2024

Background
Gamma-glutamyl transferase (GGT) has been identified to correlate with systemic inflammation in autoimmune diseases, while the role of GGT in anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (MDA5 + DM) remains unknown. This study aimed to investigate the clinical and prognostic significance of serum GGT in MDA5 + DM patients.
Methods
Patients with MDA5 + DM admitted to the First Affiliated Hospital of Zhengzhou University between February 2019 and May 2023 were retrospectively analyzed. We compared the clinical features and prognosis between MDA5 + DM patients with elevated serum GGT levels and those with normal serum GGT levels. Cox regression analysis was performed to identify independent factors associated with mortality.
Results
A total of 299 MDA5 + DM patients were enrolled in this study. During the median follow-up time of 13.1(4.4–28.1) months, 153(51.2%) patients developed rapidly progressive interstitial lung disease (RP-ILD) and 75(25.1%) patients died within 6 months after disease onset. Serum GGT levels were significantly higher in the death group compared to the survival group [95(56–165) vs 45(26–90) U/L, p<0.001]. Based on the serum GGT levels at the time of diagnosis, we divided all the patients into two groups: normal GGT group (GGT ≤ 58U/L, n = 155) and elevated GGT group (GGT>58U/L, n = 144). Compared with the normal GGT group, patients in the elevated GGT group had increased incidences of skin ulcer and RP-ILD, higher levels of lactate dehydrogenase (LDH), Krebs Von den Lungen-6 (KL-6), ferritin and C-reactive protein (CRP), while lower levels of albumin and lymphocyte counts. Moreover, the Kaplan–Meier survival analysis demonstrated that the cumulative survival rate was significantly lower in the elevated GGT group than that in the normal GGT group (log-rank p < 0.001). Multivariate Cox regression analysis revealed that RP-ILD, GGT>58U/L, LDH>345U/L, CRP>5mg/L and anti-Ro52 antibody positivity were independent risk factors of mortality in MDA5 + DM patients.
Conclusions
Elevated serum GGT level was an independent risk factor for mortality in MDA5 + DM patients. As a novel and readily available predictor, serum GGT level may help clinicians in guiding prognostic stratification and personalized treatment.
WITHDRAWN: Seismic Modelling of Complex Hydrocarbon Traps in Shot Domain and Data Processing to Obtain Stack-Migration Sections
Authors: Boğazkesen Şerife , Karslı Hakan
Published: July 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
A Survey of Essential Anatomy from the Perspective of Anesthesiology, Emergency Medicine, Obstetrics and Gynecology, and Orthopedics Resident Physicians
Authors: Harmon Derek J. , Hankin Mark H. , Martindale James R. , Niculescu Iuliana , Aschmetat Adrienne , Hanke Rachel E. , Koo Andrew S. , Carpenter Shannon R. , Emmanuel Pamela E. , Pokropek Catherine M. , Koltun Ksenia
Published: July 2024

Background
Recent changes in anatomy curricula in undergraduate medical education (UME), including pedagogical changes and reduced time, pose challenges for foundational learning. Consequently, it is important to determine the essential content for an effective anatomy curriculum.
Methods
This study surveyed 55 non-primary care residents in anesthesiology (AN; N = 6), emergency medicine (EM; N = 15), obstetrics and gynecology (OB; N = 13), and orthopedics (OR; N = 21) to assess the importance of 907 anatomical structures across all anatomical regions. Survey ratings by participants were converted into a post-hoc classification system to provide end-users of this data with an intuitive and useful classification system for categorizing individual anatomical structures (i.e., essential, more important, less important, not important).
Results
Significant variability was observed in the classifications of essential anatomy: 29.1% of all structures were considered essential by OB residents, 37.6% for AN residents, 41.6% for EM residents, and 72.0% for OR residents. Significant differences (with large effect sizes) were also observed between residency groups: OR residents rated anatomy of the back, limbs, and pelvis and perineum anatomy common to both sexes significantly higher, whereas OB residents rated the pelvis and perineum anatomy common to both sexes and anatomy for individuals assigned female at birth highest. Agreement in classifications of importance among residents was observed for selected anatomical structures in the thorax, abdomen, pelvis and perineum (assigned male at birth-specific anatomy), and head and neck. As with the ratings of anatomical structures, OR residents had the highest classification across all nine tissue types (p < 0.01).
Conclusions
The present study, in combination with Hankin et al. (2023), which surveyed primary care residents, contributes to a database of anatomical structures assessed from a clinical perspective that may be considered when determining foundational anatomy for UME curriculum, as well as for graduate medical education.