bluuebunny/crossref_metadata_2025 huggingface dataset:
Analytical Modeling of Emulsion Flow at the Edge of a Steam Chamber During a Steam-Assisted-Gravity-Drainage Process
Authors: Mojarad Mahdie , Dehghanpour Hassan
Published: February 2016

Recently, different models were proposed to describe two- and three-phase flow at the edge of a steam chamber developed during a steam-assisted-gravity-drainage (SAGD) process. However, 2D-scaled SAGD experiments and recent micromodel visualizations demonstrate that steam condensate is primarily in the form of microbubbles dispersed in the oil phase (water-in-oil emulsion). Therefore, the challenging question is: Can the multiphase Darcy equation be used to describe the transport of water as a discontinuous phase? Furthermore, the physical impact of water as a continuous phase or as microbubbles on oil flow can be different. Water microbubbles increase the apparent oil viscosity, whereas a continuous water phase decreases the oil relative permeability. Investigating the impact of these two phenomena on oil mobility at the steam-chamber edge and on overall oil-production rate during an SAGD process requires development of relevant mathematical models, which is the focus of this paper.

In this paper, we develop an analytical model for lateral expansion of the steam chamber that accounts for formation and transport of water-in-oil emulsion. It is assumed that emulsion is generated as a result of condensation of steam, which penetrates into the heated bitumen. The emulsion concentration decreases from a maximum value at the chamber interface to zero far from the interface. The oil viscosity is affected by both temperature gradient caused by heat conduction and microbubble concentration gradient resulting from emulsification. We conduct a sensitivity analysis with the measured data from scaled SAGD experiments. The sensitivity analysis shows that, by increasing the value of m (temperature viscosity parameter), the effect of emulsification on oil-flow rate decreases. It also shows that the effect of temperature on oil mobility is much stronger than that of emulsion. We also compare the model predictions with field production data from several SAGD operations. Butler's model overestimates oil-production rate caused by the single-phase assumption, whereas the proposed model presents more-accurate oil-flow rate, supporting the fact that one should include emulsification effect in the SAGD analysis.
Water services sector reform: the Kosova experience
Authors: Begolli B. , Lajçi A.
Published: February 2016

Governments of countries with emerging economies usually are not very successful in providing safe and sufficient potable water and adequate wastewater services to their citizens. The reasons vary from inadequate institutional structures to chronic under-investment in water infrastructure. To address this, governments embark on reforms based on commonly accepted principles of good governance such as: separation of policy, regulation and service delivery; protecting customer interests; and ensuring financial viability of water utilities and restructuring them so as to benefit from economies of scale and economies of scope. Kosova initiated water sector reforms in 2000 based on five pillars: (i) establishment of a legal and institutional framework, (ii) consolidation of 30 municipal water utilities into seven regional entities, (iii) incorporation in line with corporate governance principles, (iv) establishment of an independent economic regulator and (v) ownership and pushing of reforms by government. The paper describes the challenges encountered in implementing these reforms which, as far as the institutional and legislative framework is concerned, were successfully completed by 2008. Also, the difficulties associated with consolidation of newly created institutions resulting from the reform and defining their roles in the water services sector are described in the paper.
Free-living amoebae isolated from a hospital water system in South Africa: a potential source of nosocomial and occupational infection
Authors: Muchesa P. , Leifels M. , Jurzik L. , Barnard T. G. , Bartie C.
Published: February 2016

This study investigated the occurrence of free-living amoebae (FLA) in a public hospital in South Africa. A total of 97 water and biofilm samples from the municipal water inlet of the hospital, theatres, theatre sterilization service unit, central sterilization service unit, endoscopy/gastroscopy unit, intensive care unit and the renal unit were collected and examined for the presence of FLA using an amoebal co-culture and molecular techniques. Of the 97 samples, 77 (79.4%), 40 (52%) water and 37 (48.1%) biofilm, contained FLA. The genera Acanthamoeba, Vermamoeba (formerly Hartmanella) and Naegleria were detected by morphology, 18S rRNA PCR (polymerase chain reaction) and sequence analyses. Further sequence analysis of the five Acanthamoeba-positive isolates revealed a close resemblance with the potentially pathogenic T20 genotype. These results show a potential health risk to immuno-compromised patients and health care workers as some of the species detected are pathogenic and may harbor potential intracellular bacteria responsible for nosocomial infections. To date, this is the first report on the detection of potentially pathogenic amoebae from South African hospital water systems.
Quantifying the robustness of optimal reservoir operation for the Xinanjiang-Fuchunjiang Reservoir Cascade
Authors: Vonk E. , Xu Y. P. , Booij M. J. , Augustijn D. C. M.
Published: February 2016

In this research we investigate the robustness of the common implicit stochastic optimization (ISO) method for dam reoperation. As a case study, we focus on the Xinanjiang-Fuchunjiang reservoir cascade in eastern China, for which adapted operating rules were proposed as a means to reduce the impact of climate change and socio-economic developments. The optimizations were based on five different water supply and demand scenarios for the future period from 2011 to 2040. Main uncertainties in the optimization can be traced back to correctness of the assumed supply and demand scenarios and the quality and tuning of the applied optimization algorithm. To investigate the robustness of proposed operation rules, we (1) compare cross-scenario performance of all obtained Pareto-optimal rulesets and (2) investigate whether different metaheuristic optimization algorithms lead to the same results. For the latter we compare the originally used genetic algorithm (Nondominated Sorting Genetic Algorithm II, NSGA-II) with a particle swarm optimization algorithm (MOPSO). Reservoir performance was measured using the shortage index (SI) and mean annual energy production (MAEP) as main indicators. It is found that optimal operating rules, tailored to a specific scenario, deliver at most 2.4% less hydropower when applied to a different scenario, while the SI increases at most with 0.28. NSGA-II and MOPSO are shown to yield approximately the same Pareto-front for all scenarios, even though small differences can be observed.
Disinfection characteristics of the combined ultraviolet radiation and ozone process using Escherichia coli as a probe
Authors: Wu Donghai , Lu Guanghua , Zhang Ran , You Hong , Yan Zhenhua , Li Yi
Published: February 2016

In the present study, the characteristics of the combined ultraviolet (UV) and ozone disinfection process were investigated from kinetic and mechanistic viewpoints employing Escherichia coli (E. coli) as an indicator microorganism. Compared to individual unit processes, the combined UV/O3 tests produced excess hydroxyl radicals (HO•) and yielded synergistic inactivation of E. coli in the initial phase of reaction. The presence of O3 during UV exposure caused the destruction of cell structure, and then repressed bacteria regrowth after treatment. Moreover, the formation of malondialdehyde (MDA) showed that the improved generation of intermediate HO• via ozone photolysis accelerated the decomposition of bacterial cell surfaces, which was further confirmed by the leakage of intracellular potassium ions (K+). The results suggested that the synergistic bactericidal effect of combined UV/O3 owed mainly to the enhanced destruction of bacterial cell structure.
Using PAC-modified clays to control black-bloom-induced black suspended matter in Lake Taihu: deposition and resuspension of black matter/clay flocs
Authors: Huang Yawen , Pang Yong , Wang Guoxiang , Han Ruiming , Wang Jianjian , Zhang Peng , Xu Lei
Published: February 2016

Flocculation using modified clays is a technique widely applied in the management of harmful algal blooms (HABs). Polyaluminum chloride (PAC) modified clay is an efficient flocculating agent in HAB control; however its effectiveness in black bloom management is still largely unknown. In the present study, PAC-modified clay was used to flocculate a black bloom under simulated flows. The deposition and resuspension of the black matter/clay flocs and the impact of the spreading of quartz sand to the flocs were quantitatively studied. The results showed that a dosage of 1.8 g/L PAC-modified clay (0.8 g/L PAC and 1 g/L diatomite) could reduce turbidity by more than 90% in 1 h. The resuspension of flocs could be generated by a threshold bed shear stress of 0.045 N/m2. The addition of quartz sand inhibited the resuspension of flocs. We suggest that quartz sand can be used to effectively inhibit floc resuspension caused by waves and flow currents as the subsequent treatment of black bloom flocculation in Lake Taihu.
Use of synthesized hydrophilic magnetic nanoparticles (HMNPs) in forward osmosis for water reuse
Authors: Mishra Tripti , Ramola Sudipta , Shankhwar Anil Kumar , Srivastava R. K.
Published: February 2016

Forward osmosis (FO) is attracting worldwide attention as an emerging technology in the fields of power generation, water reuse, desalination, pharmaceuticals and food processing. Still, the critical challenge of finding a suitable draw solute for FO persists. Therefore the current research focuses on synthesizing hydrophilic magnetic nanoparticles (HMNPs) and systematically investigating their potential as draw solutes. HMNPs were synthesized using functional groups polyethylene glycol (PEG 400) and polyacrylic acid (PAA). These functional groups under different ratios with a metal precursor react by one-pot polyol and thermal decomposition methods respectively to give different diameter HMNPs. In addition the effect of different sizes of synthesized HMNPs was investigated for their recovery under an external magnetic field and reusability in FO performance. The physical properties and chemical compositions of the resultant MNPs are fully characterized. Transmission electron microscopy (TEM) analyses show the characteristics as spherical morphology with a narrow size distribution, and a mean size from 9 to 32.5 nm for PEG and 8 to 30 nm for PAA coated HMNPs depending on the ratio of the functional group and metal precursor. The PEG and PAA layer on the MNPs is confirmed by Fourier transform infrared (FTIR) analysis, and thermogravimetric analysis demonstrates a hydrophilic surface composition. The PEG and PAA coated HMNPs generate high osmotic pressures and exhibit good dispersibility in aqueous solutions. Water fluxes of >13 L m−2 h−1 are achieved across Hydration Technologies Inc. flat sheet membranes at a concentration of 0.05 M of HMNPs using deionized water as the feed solution. The HMNPs can be easily recaptured from draw solutions by applying an external magnetic field and recycling them back as draw solute in the FO process. The MNPs remain active after nine runs of recycling but with a total water flux decrease of 5% in PEG and 3% with each successive recycling due to slight aggregation, and reduced surface to volume ratio is observed. Results of the present study have demonstrated that PEG and PAA coated HMNPs can viewed as promising and potential draw solutes in the FO process.
Confirmed inguinal lymphogranuloma venereum genovar L2c in a man who had sex with men, Slovenia, 2015
Authors: Matičič Mojca , Klavs Irena , Videčnik Zorman Jerneja , Vidmar Vovko Darja , Kogoj Rok , Keše Darja
Published: February 2016

A laboratory-confirmed lymphogranuloma venereum (LGV) case in Slovenia was reported in 2015, in a human immunodeficiency virus (HIV)-negative man presenting with inguinal lymphadenopathy. He reported unprotected insertive anal intercourse with two male partners in Croatia. Variant L2c of Chlamydia trachomatis was detected in clinical samples. Although the patient was eventually cured, the recommended treatment regimen with doxycycline had to be prolonged.
Improving the Understanding of Psychological Factors Contributing to Horse-Related Accident and Injury: Context, Loss of Focus, Cognitive Errors and Rigidity
Authors: DeAraugo Jodi , McLaren Suzanne , McManus Phil , McGreevy Paul
Published: February 2016

While the role of the horse in riding hazards is well recognised, little attention has been paid to the role of specific theoretical psychological processes of humans in contributing to and mitigating risk. The injury, mortality or compensation claim rates for participants in the horse-racing industry, veterinary medicine and equestrian disciplines provide compelling evidence for improving risk mitigation models. There is a paucity of theoretical principles regarding the risk of injury and mortality associated with human–horse interactions. In this paper we introduce and apply the four psychological principles of context, loss of focus, global cognitive style and the application of self as the frame of reference as a potential approach for assessing and managing human–horse risks. When these principles produce errors that are combined with a rigid self-referenced point, it becomes clear how rapidly risk emerges and how other people and animals may repeatedly become at risk over time. Here, with a focus on the thoroughbred racing industry, veterinary practice and equestrian disciplines, we review the merits of contextually applied strategies, an evolving reappraisal of risk, flexibility, and focused specifics of situations that may serve to modify human behaviour and mitigate risk.
Surface Ozone Concentration and Its Relationship with UV Radiation, Meteorological Parameters and Radon on the Eastern Coast of the Baltic Sea
Authors: Jasaitis Dainius , Vasiliauskienė Vaida , Chadyšienė Renata , Pečiulienė Milda
Published: February 2016

Hourly and daily variations of ground-level ozone have been analyzed in relation to meteorological parameters, UVB radiation and radon near the Baltic Sea in Lithuania. An atypical situation with respect to wind domination was observed during the experiment: the wind from the continent was twice as frequent as the wind from the sea. The close correlation between ground-level ozone concentration and UVB radiation intensity was established. The vertical migration directions of ozone and radon were opposite and the negative correlation between these pollutants was observed. The diurnal course of ozone and radon and the influence of meteorological parameters (temperature, relative air humidity, wind speed and direction) on variation of these pollutants have been estimated. It was established that the wind direction domination during the experiment had a significant influence on the variation of ozone and radon concentrations.
In Vivo Efficacy of Artesunate/Sulphadoxine-Pyrimethamine versus Artesunate/Amodiaquine in the Treatment of Uncomplicated P. falciparium Malaria in Children around the Slope of Mount Cameroon: A Randomized Controlled Trial
Authors: Apinjoh Tobias , Anchang-Kimbi Judith , Ajonina Marcelus , Njonguo Esther , Njua-Yafi Clarisse , Ngwai Andre , Mugri Regina , Achidi Eric
Published: February 2016

Background: The development and spread of antimalarial drug resistant parasites contributes to the global impact of the disease. In vivo efficacy assessments of treatments for Plasmodium falciparum malaria are essential for ensuring effective case management. Artemisinin-based combinations have been adopted as the first-line treatment for uncomplicated P. falciparum malaria in Cameroon since 2004. Methods: A total of 177 children aged six-months to 10 years with uncomplicated mono-infected falciparum malaria were randomized (1:1) to receive artesunate/sulphadoxine-pyrimethamine (AS/SP) or artesunate/amodiaquine (AS/AQ) pediatric tablets and followed up for 28 days according to the standard World Health Organization in vivo drug efficacy monitoring protocol. The primary and secondary endpoints were PCR uncorrected and corrected cure rates, as measured by adequate clinical and parasitological response (ACPR) on day 28. Results: The PCR corrected cure rate was high, overall (88.1%, 95% CI 83.1–93.1), 85.9% (95% CI 78.2–93.6), and 90.2% (95% CI 83.8–96.6) for AS/SP and AS/AQ, respectively. Twenty-one treatment failures were observed during follow-up, constituting one (4.6%), 14 (8.2%), and six (3.5%) early treatment failure (ETF), late clinical failure (LCF), and late parasitological failure (LPF), respectively. The drugs were well tolerated with no serious adverse events. Conclusions: Both AS/SP and AS/AQ are highly effective and well-tolerated treatments for uncomplicated P. falciparum malaria around the slope of Mount Cameroon.
Manganese Oxide Coated Carbon Materials as Hybrid Catalysts for the Application in Primary Aqueous Metal-Air Batteries
Authors: Flegler Andreas , Hartmann Sarah , Weinrich Henning , Kapuschinski Martina , Settelein Jochen , Lorrmann Henning , Sextl Gerhard
Published: February 2016

One of the major challenges of metal-air batteries is the impeded oxygen reduction reaction (ORR) during discharge occurring at the gas diffusion electrode (GDE) of the battery. Due to the impeded ORR, high overpotentials emerge and result in a loss of energy efficiency. In order to improve the latter, suitable catalysts have to be employed. Transition metal oxides like manganese oxides (e.g., MnO2, Mn2O3, Mn3O4, Mn5O8, MnOOH) [1,2] are known as good and inexpensive materials for the ORR in alkaline media. A drawback of manganese oxide catalysts is the poor electrical conductivity. Hence, the approach presented in this work aims to enhance the catalytic activity of Mn3O4 and γ–MnO2 by the incorporation of conductive carbon material into the pure manganese oxide. The resulting hybrid catalysts are prepared either by impregnation of Super C 65, Vulcan XC 72, and Kuraray YP 50F via a sol-gel technique employing a MnO2 precursor sol or by direct precipitation of Mn3O4 or γ–MnO2 particles in the presence of the carbon materials mentioned above. Investigations by rotating disc electrode (RDE) show a noticeably higher catalytic activity of the hybrid catalysts than for the pure materials. For verification of the results measured by RDE, screen printed GDEs are prepared and tested in Zn-air full cells.
What Effect Does International Migration Have on the Nutritional Status and Child Care Practices of Children Left Behind?
Authors: Jayatissa Renuka , Wickramage Kolitha
Published: February 2016

Despite an increasing trend in labour migration and economic dependence on foreign migrant workers in Sri Lanka, very little is known about the child care and nutritional status of “children left behind”. The aim of this study was to examine the factors influencing the nutritional status and care practices of children left behind. A sample of 321 children, 6–59 months old of international migrant workers from a cross-sectional nationally represented study were included. Care practices were assessed using ten caregiving behaviours on personal hygiene, feeding, and use of health services. Results revealed the prevalence of stunting, wasting and underweight to be 11.6, 18.2 and 24.0 percent, respectively. Father being a migrant worker has a positive effect on childcare practices and birthweight of the child. This study indicates that undernutrition remains a major concern, particularly in the poorest households where the mother is a migrant worker, also each additional 100 g increase in the birthweight of a child in a migrant household, decreases the probability of being wasted, stunted and underweight by 6%, 8% and 23% respectively. In depth study is needed to understand how labour migration affects household level outcomes related to child nutrition and childcare in order to build skills and capacities of migrant families.
Food-Derived Bioactives Can Protect the Anti-Inflammatory Activity of Cortisol with Antioxidant-Dependent and -Independent Mechanisms
Authors: Ruijters Erik , Haenen Guido , Willemsen Mathijs , Weseler Antje , Bast Aalt
Published: February 2016

In chronic inflammatory diseases the anti-inflammatory effect of glucocorticoids (GCs) is often decreased, leading to GC resistance. Inflammation is related with increased levels of reactive oxygen species (ROS), leading to oxidative stress which is thought to contribute to the development of GC resistance. Plant-derived compounds such as flavonoids are known for their ability to protect against ROS. In this exploratory study we screened a broad range of food-derived bioactives for their antioxidant and anti-inflammatory effects in order to investigate whether their antioxidant effects are associated with the ability to preserve the anti-inflammatory effects of cortisol. The anti-inflammatory potency of the tested compounds was assessed by measuring the oxidative stress–induced GC resistance in human macrophage-like cells. Cells were pre-treated with H2O2 (800 µM) with and without bioactives and then exposed to lipopolysaccharides (LPS) (10 ng/mL) and cortisol (100 nM). The level of inflammation was deducted from the concentration of interleukin-8 (IL-8) in the medium. Intracellular oxidative stress was measured using the fluorescent probe 2′,7′-dichlorofluorescein (DCFH). We found that most of the dietary bioactives display antioxidant and anti-inflammatory action through the protection of the cortisol response. All compounds, except for quercetin, revealing antioxidant activity also protect the cortisol response. This indicates that the antioxidant activity of compounds plays an important role in the protection of the GC response. However, next to the antioxidant activity of the bioactives, other mechanisms also seem to be involved in this protective, anti-inflammatory effect.
Explaining Patterns of Urban Violence in Medellin, Colombia
Authors: Doyle Caroline
Published: February 2016

Latin America is one of the world’s most violent regions, with 40 of the 50 most violent cities, but with only 8% of the world’s population, and a staggering 33% of global homicides. At the forefront of these high levels of violence are gangs that are more flexible and persistent than previously thought. This paper provides a discussion on gangs in one Latin American city, Medellin, Colombia, where different non-state groups have contributed to changing patterns of homicide rates. The paper presents preliminary findings to show how, despite the city experiencing a 90% reduction in homicide rates in less than 25 years, violent non-state groups have become embedded as part and product of their environment, acting as coherent, logical and functional players, linked to the structural inequalities and institutional fragility of the larger society.
Microstructures and Mechanical Properties of Austempering SUS440 Steel Thin Plates
Authors: Chen Cheng-Yi , Hung Fei-Yi , Lui Truan-Sheng , Chen Li-Hui
Published: February 2016

SUS440 is a high-carbon stainless steel, and its martensite matrix has high heat resistance, high corrosion resistance, and high pressure resistance. It has been widely used in mechanical parts and critical materials. However, the SUS440 martempered matrix has reliability problems in thin plate applications and thus research uses different austempering heat treatments (tempering temperature: 200 °C–400 °C) to obtain a matrix containing bainite, retained austenite, martensite, and the M7C3 phase to investigate the relationships between the resulting microstructure and tensile mechanical properties. Experimental data showed that the austempering conditions of the specimen affected the volume fraction of phases and distribution of carbides. After austenitizing heat treatment (1080 °C for 30 min), the austempering of the SUS440 thin plates was carried out at a salt-bath temperature 300 °C for 120 min and water quenching was then used to obtain the bainite matrix with fine carbides, with the resulting material having a higher tensile fracture strength and average hardness (HRA 76) makes it suitable for use as a high-strength thin plate for industrial applications.
Histone Deacetylase 6 Regulates Bladder Architecture and Host Susceptibility to Uropathogenic Escherichia coli
Authors: Lewis Adam , Dhakal Bijaya , Liu Ting , Mulvey Matthew
Published: February 2016

Histone deacetylase 6 (HDAC6) is a non-canonical, mostly cytosolic histone deacetylase that has a variety of interacting partners and substrates. Previous work using cell-culture based assays coupled with pharmacological inhibitors and gene-silencing approaches indicated that HDAC6 promotes the actin- and microtubule-dependent invasion of host cells by uropathogenic Escherichia coli (UPEC). These facultative intracellular pathogens are the major cause of urinary tract infections. Here, we examined the involvement of HDAC6 in bladder colonization by UPEC using HDAC6 knockout mice. Though UPEC was unable to invade HDAC6−/− cells in culture, the bacteria had an enhanced ability to colonize the bladders of mice that lacked HDAC6. This effect was transient, and by six hours post-inoculation bacterial titers in the HDAC6−/− mice were reduced to levels seen in wild type control animals. Subsequent analyses revealed that the mutant mice had greater bladder volume capacity and fluid retention, along with much higher levels of acetylated a-tubulin. In addition, infiltrating neutrophils recovered from the HDAC6−/− bladder harbored significantly more viable bacteria than their wild type counterparts. Cumulatively, these changes may negate any inhibitory effects that the lack of HDAC6 has on UPEC entry into individual host cells, and suggest roles for HDAC6 in other urological disorders such as urinary retention.
Self-Assembly of Discrete Metallocycles versus Coordination Polymers Based on Cu(I) and Ag(I) Ions and Flexible Ligands: Structural Diversification and Luminescent Properties
Authors: Vallejos Javier , Brito Iván , Cárdenas Alejandro , Bolte Michael , Conejeros Sergio , Alemany Pere , Llanos Jaime
Published: February 2016

Three new Ag(I) and one Cu(I) coordination compounds with two different positional isomers, propane-1,3-diyl bis(pyridine-4-carboxylate) (L1) and propane-1,3-diyl bis(pyridine-3-carboxylate) (L2), of a bis-(pyridyl-carboxylate) ligand have been synthesized. X-ray diffraction analysis revealed that the self-assembly of L1 with AgCF3SO3 and AgClO4 salts leads to the formation of discrete binuclear metallocycles {Ag(L1)CF3SO3}2 (1) and {Ag(L1)ClO4}2 (2), respectively. However, self-assembly of the other ligand, L2, with AgCF3SO3 and CuCl salts, results in a 1-D zig-zag chain {Ag(L2)CF3SO3}∞ (3) and a 1-D double-stranded helical chain {Cu2Cl2(L2)2}∞ (4) coordination polymers, respectively. Solid emission spectra recorded at room temperature show interesting luminescence properties for all four compounds in the range from 438 to 550 nm, especially for compound 4 that was found to change its emission color when the wavelength of the excitation radiation is switched from 332 to 436 nm.
Removing the Interdependency between Horizontal and Vertical Eye-Movement Components in Electrooculograms
Authors: Chang Won-Du , Cha Ho-Seung , Im Chang-Hwan
Published: February 2016

This paper introduces a method to remove the unwanted interdependency between vertical and horizontal eye-movement components in electrooculograms (EOGs). EOGs have been widely used to estimate eye movements without a camera in a variety of human-computer interaction (HCI) applications using pairs of electrodes generally attached either above and below the eye (vertical EOG) or to the left and right of the eyes (horizontal EOG). It has been well documented that the vertical EOG component has less stability than the horizontal EOG one, making accurate estimation of the vertical location of the eyes difficult. To address this issue, an experiment was designed in which ten subjects participated. Visual inspection of the recorded EOG signals showed that the vertical EOG component is highly influenced by horizontal eye movements, whereas the horizontal EOG is rarely affected by vertical eye movements. Moreover, the results showed that this interdependency could be effectively removed by introducing an individual constant value. It is therefore expected that the proposed method can enhance the overall performance of practical EOG-based eye-tracking systems.
Enhanced ICP for the Registration of Large-Scale 3D Environment Models: An Experimental Study
Authors: Han Jianda , Yin Peng , He Yuqing , Gu Feng
Published: February 2016

One of the main applications of mobile robots is the large-scale perception of the outdoor environment. One of the main challenges of this application is fusing environmental data obtained by multiple robots, especially heterogeneous robots. This paper proposes an enhanced iterative closest point (ICP) method for the fast and accurate registration of 3D environmental models. First, a hierarchical searching scheme is combined with the octree-based ICP algorithm. Second, an early-warning mechanism is used to perceive the local minimum problem. Third, a heuristic escape scheme based on sampled potential transformation vectors is used to avoid local minima and achieve optimal registration. Experiments involving one unmanned aerial vehicle and one unmanned surface vehicle were conducted to verify the proposed technique. The experimental results were compared with those of normal ICP registration algorithms to demonstrate the superior performance of the proposed method.
An Insight into the Triabin Protein Family of American Hematophagous Reduviids: Functional, Structural and Phylogenetic Analysis
Authors: Hernández-Vargas María , Santibáñez-López Carlos , Corzo Gerardo
Published: February 2016

A transcriptomic analysis of the saliva of T. pallidipennis together with a short proteomic analysis were carried out to reveal novel primary structures of the lipocalin/triabin protein families in this reduviid. Although triabins share some structural characteristics to lipocalins and they are classified as in the calcyn/lipocalin superfamily, triabins differ from lipocalins in the direction of β-strands in the general conformation of the β-barrel. The triabin protein family encompasses a wide variety of proteins, which disrupt the hemostasis of warm-blooded animals. Likewise, the function of proteins classified as triabins includes proteins that are carriers of small molecules, protease inhibitors, binders of specific cell-surface receptors as well as proteins that form complexes with other macromolecules. For example, triabin and pallidipin from the saliva of T. pallidipennis are thrombin and platelet aggregation inhibitors, respectively; triplatin from T. infestans binds to thromboxane A2; and nitrophorin from Rhodnius prolixus carries nitric oxide. Therefore, based on 42 new transcriptome sequences of triabins from the salivary glands of T. pallidipennis reported at present, and on triabin sequences of other American hematophagous reduviids already reported in the literature, subfamilies of triabins were proposed following phylogenetic analyses and functional characterization of triabin members. Eight subfamilies of proteins were recognized with known functions, which were the nitrophorin and amine binding proteins, Rhodnius prolixus aggregation inhibitor, triafestin, triatin, dipetalodipin and pallidipin, triplatin and infestilin, dimiconin and triabin, and procalin subfamilies. Interestingly, 70% of the analyzed sequences came from these eight subfamilies because there was no biological function associated with them, implying the existence of a vast number of proteins with potential novel biological activities.
Charles Dickens and
Barnaby Rudge
: The First Description of Williams Syndrome?
Authors: Eblovi Darren , Clardy Christopher
Published: February 2016

Williams syndrome, a disorder caused by a genetic deletion and characterized by moderate intellectual disability with relatively strong language skills and a hypersocial personality, was first described in the medical literature in 1961. However, 120 years earlier, Charles Dickens wrote the novel
Barnaby Rudge
, which follows an “idiot” through London's Gordon Riots of 1780. We propose that Dickens based this character on a person he knew with Williams syndrome. Common features include an “elfin” face, decreased cognitive ability and dependence on a caretaker, strong language skills with emphatic and perseverative speech, anxiety, and an empathetic, overly trusting personality. In the novel, these traits lead the character Barnaby to be duped into actively participating in the riots, which nearly results in his hanging. This example of fiction providing a description of a disorder more detailed than that of medical journals more than a century later should encourage physicians to look to sources beyond traditional scientific articles for valuable clinical information.

[
Pediatr Ann
. 2016;45(2):e67–e69.]
Hereditary Pancreatitis
Authors: Rivera Rivera Edgardo D. , Chugh Ankur , Cordova Jonathon , Young Sona
Published: February 2016

A 13-year-old boy with a strong family history of hereditary pancreatitis was found to have a
PRSS1
mutation after being tested at age 5 years during his first documented incident of pancreatitis. Since then, a multidisciplinary team has been treating him for the diagnosis of hereditary pancreatitis. His pain episodes increased in severity over the past several months such that the pain began to severely interfere with his daily life. After extensive discussion, a total pancreatectomy with auto islet cell transplant was performed. He is now pain free and does not require any insulin. This leads us to the questions of what is hereditary pancreatitis and how is it diagnosed? What are the management and follow-up strategies needed for these patients? This article addresses these questions and informs the reader about this diagnosis and the importance of having a high index of clinical suspicion.

[
Pediatr Ann
. 2016;45(2):e50–e53.]
Evaluation of Preretinal Neovascularization in Proliferative Diabetic Retinopathy Using Optical Coherence Tomography Angiography
Authors: de Carlo Talisa E. , Bonini Filho Marco A. , Baumal Caroline R. , Reichel Elias , Rogers Adam , Witkin Andre J. , Duker Jay S. , Waheed Nadia K.
Published: February 2016

BACKGROUND AND OBJECTIVE:

To describe a method for visualizing preretinal neovascularization in proliferative diabetic retinopathy (PDR) using optical coherence tomography angiography (OCTA) and report the findings in the surrounding vasculature.

PATIENTS AND METHODS:

Patients with PDR diagnosed on clinical examination who received OCTA scans using the RTVue XR Avanti (Optovue, Fremont, CA) were evaluated. To visualize preretinal neovascularization, OCT angiograms were segmented to project vasculature above the internal limiting membrane (ILM). OCT angiograms were segmented between the ILM and Bruch's membrane to show adjacent retinal vasculature.

RESULTS:

Thirteen eyes were determined to have preretinal neovascularization in the posterior pole based on OCTA. One OCT angiogram was not of sufficient quality and thus was eliminated from further study. Eleven eyes (92%) had neovascularization adjacent to retinal capillary nonperfusion and six (50%) were adjacent to intraretinal microvascular abnormalities (IRMAs).

CONCLUSION:

OCTA provided high-resolution, depth-resolved blood flow information, allowing for visualization of preretinal neovascularization, IRMA, and adjacent capillary nonperfusion.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:115–119.]
Intravitreal Diclofenac in the Treatment of Macular Edema Due to Branch Retinal Vein Occlusion
Authors: Seth Anisha , Ghosh Basudeb , Raina Usha K. , Gupta Anika , Arora Supriya
Published: February 2016

BACKGROUND AND OBJECTIVE:

To evaluate the effect of a single dose of intravitreal diclofenac on macular edema (ME) due to branch retinal vein occlusion (BRVO).

PATIENTS AND METHODS:

In this prospective, interventional case series, 15 eyes with BRVO and ME with central macular thickness (CMT) greater than 250 µm on spectral-domain optical coherence tomography (SD-OCT) were enrolled. All patients were given 0.05 mg/0.1 mL of intravitreal diclofenac under aseptic conditions and followed up for 3 months with respect to best-corrected visual acuity (BCVA), intraocular pressure (IOP), fundus fluorescein angiography, and CMT measured on OCT.

RESULTS:

The mean visual acuity improved from 0.115 ± 0.03 preoperatively to 0.356 ± 0.29 at 3 months (
P
= .002). Mean line improvement was 2.2 ± 1.6. Mean preoperative CMT decreased from 453.2 µm ± 55.3 µm to 340.47 µm ± 101 µm at 3 months postoperatively (
P
= .001). The mean preoperative IOP was 16.4 mm Hg ± 1.59 mm Hg, whereas the mean postoperative IOP was 16.6 mm Hg ± 1.58 mm Hg (
P
= .08). None of the 12 phakic eyes showed evidence of cataract progression.

CONCLUSION:

Intravitreal diclofenac is safe and effective in improving BCVA and decreasing CMT in patients with BRVO and ME.

[
Ophthalmic Surg Imaging Lasers Retina
. 2016;47:149–155.]
A Biological Tissue Adhesive and Dissolvent System for Intraocular Tumor Plaque Brachytherapy
Authors: Zloto Ofira , Vishnevskia-Dai Vicktoria , Moisseiev Joseph , Belkin Michael , Fabian Ido Didi
Published: February 2016

PURPOSE:

To examine a novel technique for simplified placement and removal of plaque brachytherapy by fibrin glue and urokinase (medac Gmbh, Hamburg, Germany).

MATERIALS AND METHODS:

In six enucleated porcine eyes, plaques were placed on the episclera and fibrin glue was applied to cover it. Urokinase was used to dissolve the glue in three eyes and saline was used in three eyes. Adhesion strength was measured further on 15 plaques affixed to porcine eyes (glued in five with intact conjunctiva, glued in five with removed conjunctiva, and sutured in five).

RESULTS:

Saline had no effect on the glue-plaque-eye complex, whereas the urokinase (0.38 mL ± 0.08 mL) easily dissolved the adhesion between the glue layer and surrounding tissues. The weight required to detach the plaques was 0.349 kg ± 0.173 kg for glued eyes with intact conjunctiva, 0.405 kg ± 0.083 kg for sutured eyes (
P
= .59), and 0.032 kg ± 0.004 kg for glued eyes without intact conjunctiva (
P
≤ .015).

CONCLUSIONS:

The usage of the biological adhesive and dissolvent system was applicable for plaque surgery in an ex vivo animal model.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:163–170.]
Implantation of Modular Photovoltaic Subretinal Prosthesis
Authors: Lee Dae Yeong , Lorach Henri , Huie Phil , Palanker Daniel
Published: February 2016

BACKGROUND AND OBJECTIVE:

Establish the surgical procedure for subretinal implantation of multiple photovoltaic arrays for the restoration of sight.

MATERIALS AND METHODS:

Multiple silicon photovoltaic arrays of 1 mm in diameter and 30 µm in thickness were implanted subretinally via single retinotomy in rabbits. Ophthalmoscopic imaging and optical coherence tomography (OCT) were used to validate the implants' placement.

RESULTS:

Vitrectomy, followed by subretinal fluid injection for retinal detachment and retinotomy, allowed accurate placement of seven modules in the bleb, covering approximately a 3.5-mm diameter area on the retina via a single 1.5-mm retinotomy. OCT confirmed complete reattachment of the retina over the implants.

CONCLUSION:

Subretinal implantation of multiple photovoltaic arrays via a single retinotomy, followed by their tiling, minimizes the scleral and retinal incisions and provides better fit to the spherical shape of the eye ball, compared to a single, larger module. Such minimally traumatic procedure can be performed with 20-gauge intraocular instruments.

[
Ophthalmic Surg Imaging Lasers Retina
. 2016;47:171–174.]
Sector Retinitis Pigmentosa Associated With Novel Compound Heterozygous Mutations of
CDH23
Authors: Branson Sara V. , McClintic Jedediah I. , Stamper Tara H. , Haldeman-Englert Chad R. , John Vishak J.
Published: February 2016

Usher syndrome is an autosomal recessive condition characterized by retinitis pigmentosa (RP) and congenital hearing loss, with or without vestibular dysfunction. Allelic variants of
CDH23
cause both Usher syndrome type 1D (USH1D) and a form of nonsyndromic hearing loss (DFNB12). The authors describe here a 34-year-old patient with congenital hearing loss and a new diagnosis of sector RP who was found to have two novel compound heterozygous mutations in
CDH23
, including one missense (c.8530C > A; p.Pro2844Thr) and one splice-site (c.5820 + 5G > A) mutation. This is the first report of sector RP associated with these types of mutations in
CDH23
.

[
Ophthalmic Surg Imaging Lasers Retina
. 2016;47:183–186.]
Population Viability Analysis for Endangered Roanoke Logperch
Authors: Roberts James H. , Angermeier Paul L. , Anderson Gregory B.
Published: February 2016

A common strategy for recovering endangered species is ensuring that populations exceed the minimum viable population size (MVP), a demographic benchmark that theoretically ensures low long-term extinction risk. One method of establishing MVP is population viability analysis, a modeling technique that simulates population trajectories and forecasts extinction risk based on a series of biological, environmental, and management assumptions. Such models also help identify key uncertainties that have a large influence on extinction risk. We used stochastic count-based simulation models to explore extinction risk, MVP, and the possible benefits of alternative management strategies in populations of Roanoke logperch Percina rex, an endangered stream fish. Estimates of extinction risk were sensitive to the assumed population growth rate and model type, carrying capacity, and catastrophe regime (frequency and severity of anthropogenic fish kills), whereas demographic augmentation did little to reduce extinction risk. Under density-dependent growth, the estimated MVP for Roanoke logperch ranged from 200 to 4200 individuals, depending on the assumed severity of catastrophes. Thus, depending on the MVP threshold, anywhere from two to all five of the logperch populations we assessed were projected to be viable. Despite this uncertainty, these results help identify populations with the greatest relative extinction risk, as well as management strategies that might reduce this risk the most, such as increasing carrying capacity and reducing fish kills. Better estimates of population growth parameters and catastrophe regimes would facilitate the refinement of MVP and extinction-risk estimates, and they should be a high priority for future research on Roanoke logperch and other imperiled stream-fish species.
Effects of Electric Barrier on Passage and Physical Condition of Juvenile and Adult Rainbow Trout
Authors: Layhee Megan J. , Sepulveda Adam J. , Shaw Amy , Smuckall Matthew , Kapperman Kevin , Reyes Alejandro
Published: February 2016

Electric barriers can inhibit passage and injure fish. Few data exist on electric barrier parameters that minimize these impacts and on how body size affects susceptibility, especially to nontarget fish species. The goal of this study was to determine electric barrier voltage and pulse-width settings that inhibit passage of larger bodied rainbow trout Oncorhynchus mykiss (215–410 mm fork length) while allowing passage of smaller bodied juvenile rainbow trout (52–126 mm) in a static laboratory setting. We exposed rainbow trout to 30-Hz pulsed-direct current voltage gradients (0.00–0.45 V cm−1) and pulse widths (0.0–0.7 ms) and recorded their movement, injury incidence, and mortality. No settings tested allowed all juveniles to pass while impeding all adult passage. Juvenile and adult rainbow trout avoided the barrier at higher pulse widths, and fewer rainbow trout passed the barrier at 0.7-ms pulse width compared to 0.1 ms and when the barrier was turned off. We found no effect of voltage gradient on fish passage. No mortality occurred, and we observed external bruising in 5 (7%) juvenile rainbow trout and 15 (21%) adult rainbow trout. This study may aid managers in selecting barrier settings that allow for increased juvenile passage.
Retention of Riveted Aluminum Leg Bands by Wild Turkeys
Authors: Diefenbach Duane R. , Vreeland Wendy C. , Casalena Mary Jo , Schiavone Michael V.
Published: February 2016

In order for mark–recapture models to provide unbiased estimates of population parameters, it is critical that uniquely identifying tags or marks are not lost. We double-banded male and female wild turkeys with aluminum rivet bands and estimated the probability that a bird would be recovered with both bands <1–225 wk since banding (mean = 51.2 wk, SD = 44.0). We found that 100% of females (n = 37) were recovered with both bands. For males, we recovered 6 of 188 turkeys missing a rivet band for a retention probability of 0.984 (95% CI = 0.96–0.99). If male turkeys are double-banded with rivet bands the probability of recovering a turkey without any marks is <0.001. We failed to detect a change in band retention over time or differences between adults and juveniles. Given the low cost and high retention rates of rivet aluminum bands, we believe they are an effective marking technique for wild turkeys and, for most studies, will minimize any concern about the assumption that marks are not lost.
Response of Native Species 10 Years After Rat Eradication on Anacapa Island, California
Authors: Newton Kelly M. , McKown Matthew , Wolf Coral , Gellerman Holly , Coonan Tim , Richards Daniel , Harvey A. Laurie , Holmes Nick , Howald Gregg , Faulkner Kate , Tershy Bernie R. , Croll Donald A.
Published: February 2016

Measuring the response of native species to conservation actions is necessary to inform continued improvement of conservation practices. This is particularly true for eradications of invasive vertebrates from islands where up-front costs are high, actions may be controversial, and there is potential for negative impacts to native (“nontarget”) species. We summarize available data on the response of native species on Anacapa Island, California, 10 y after the eradication of invasive black rats Rattus rattus. Native marine taxa hypothesized to respond positively to rat eradication increased in abundance (Scripps's murrelet Synthliboramphus scrippsi; International Union for Conservation of Nature Vulnerable, and intertidal invertebrates). Two seabird species likely extirpated by rats—ashy storm-petrel Oceanodroma homochroa (International Union for Conservation of Nature Endangered) and Cassin's auklet Ptychoramphus aleuticus—are now confirmed to breed on the island. Long-term negative effects from nontarget impacts are limited. Rufous-crowned sparrows Aimophila ruficeps obscura are still present, although likely in lower abundance. The endemic Anacapa deer mouse Peromyscus maniculatus anacapae population increased with no loss in heterozygosity, but with reduced genetic differentiation on East Anacapa and the loss of some alleles across the islets. Intertidal invertebrate cover increased while algal cover decreased. These findings clarify the pervasive effects of invasive rats on a wide variety of taxa, the short- and long-term impacts of eradication, and the ability of some island fauna to passively recover following a carefully planned rat-eradication project.