bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFORTS OF THE KYRGYZ PEOPLE TO ACHIEVE INDEPENDENT STATEHOOD
Authors:   K.Tynystanov Issyk-Kul State University, Kanimetov A. K. , Dzhumadylova K. T. ,   K.Tynystanov Issyk-Kul State University
Published: August 2024

In the early 20th century, during the Soviet period, the efforts of the Kyrgyz people to achieve independent statehood began with the project of creating the Kyrgyz mountainous region and ended with the creation of the Kyrgyz SSR. The article describes the efforts of the Kyrgyz people to achieve independent statehood in the Soviet period in the 20-30s of the twentieth century, which led to the formation of the Kyrgyz national statehood (on October 14, 1924 the Kyrgyz Autonomous Oblast became part of the RSFSR, in 1926 it became the Kyrgyz ASSR, and in 1936 it became a union republic - the Kyrgyz SSR) and created conditions for its economic development. During these years, Kyrgyz statehood was founded only as a result of the labors of outstanding citizens of the Kyrgyz people.
Feasibility Study for Improving Structural Properties of Manufactured Aggregates Made from Dredged Material
Authors: Nandane Shubham
Published: August 2024

Most of the dams are subjected to sedimentation and therefore Dredging is done continuously in order to keep sufficient depth in the reservoirs. Dredging is a continuous process and huge amount of dredged material is available, most of which is thrown to agricultural field or near beach for beach nourishment purpose because at present is has no commercial value. In current scenario, the disposal problem of industrial by-products like bottom ash, RHA, and the dredged material has become an environmental burden. Further, shortage of land to dispose this material also adds up the issue. In the present study these materials and/or by-products that are considered waste and pollutants were used for making artificial aggregates. On the other side, shortage of natural aggregates in the rapidly growing infrastructure industry creates a problem of depleting natural resources and is the outcome of fast polluting environment. Consequently, production of artificial aggregates solves two problems; saves environment from pollution and prevents depletion of natural resources, thereby giving a way to sustainable development. The Environmental suitability by determining the chemical composition and engineering properties of dredged material have been analyzed & then accordingly the mixes of varying percentages of the dredged material and admixtures were cast and sintered by the incorporation of existing infrastructure and capital assets to improve their structural properties. The Artificial aggregates resulted from the present research have acceptable for various strength properties tested such as crushing, abrasion, impact and soundness. Also, the use of additives and coating materials in appropriate proportions improved the structural properties of these products making them suitable to use in concrete.
VULNERABILIDADE, DIREITOS HUMANOS E DIGNIDADE HUMANA COMO FUNDAMENTOS DA POSITIVAÇÃO DO DEPOIMENTO ESPECIAL
Authors: Manssur Maria
Published: August 2024

The present work is guided by the identification of the vulnerable in the criminal process and for the reasons that justify his inclusion in a protection system established, especially for his hearing, in the two phases of criminal prosecution, as a victim or witness of violence, without risk against balance between prosecution and defense. The Law n. 13.413/2017 integrates specialized listening and special testimony with the pre-existing protective system of the vulnerable, and in this step, the principle of the judge’s integrity, which guides the interception of the law to morals and social aspirations, contributes to the conclusion of strong value of victims and witnesses’ words as evidences of violence in the criminal process. There is identification of criminal offenses committed, recurrently, against vulnerable, due to age, proving indispensable the alignment between professionals of Law, Psychology and Social Work, concerning their respective competences and ethical limitations, joining efforts to, in stages of criminal prosecution, allow the disclosure of facts relevants to the Law, in accordance with the dignity of the minor and his best interests, as the Federal Constitution guarantees.
FECHAMENTO DE COMUNICAÇÃO BUCO-SINUSAL UTILIZANDO CORPO ADIPOSO DE BICHAT: REVISÃO DE LITERATURA
Authors:   Marcelo Betti Mascaro, Oliveira Samara , Silva Suzana , Santos Leticia Catarine , Silva Fernanda , Santos Eric Filipe
Published: August 2024

The proximity of the maxillary sinuses to the roots of the upper back teeth makes these structures a major concern for dentistry. After the extraction of these teeth, communication can occur between the oral cavity and the maxillary sinus, which can cause various unpleasant symptoms for patients, such as difficulty swallowing liquids and solid foods, a feeling of pressure, altered vocal characteristics, altered taste, headache, runny nose, halitosis and purulence. In addition, other conditions such as instrument trauma, removal of cysts and tumors, and periapical lesions can also lead to oral-sinusal communication. The aim of this study is to discuss the surgical technique that uses the fatty body of the cheek, known as the Bichat ball, to treat oral-sinusal communications (OSC). Diagnosis is made through clinical and radiographic analysis, including visual and tactile inspection and the Valsalva maneuver. Imaging tests include periapical radiographs, posteroanterior Waters radiographs, panoramic radiographs and computed tomography, which is considered the “gold standard”, providing more precise information without overlapping. When the oral-sinusal communication is smaller than 2 mm, it can be treated with clot stabilization, while lesions larger than 3 mm require a surgical approach for closure within 48 hours, in order to avoid complications. Plugging techniques, such as palatal soft tissue flap rotation, cheek fat body traction, platelet-rich fibrin (PRF) application and autogenous grafting, can be applied.  With an extensive range of techniques at our disposal for correcting intraoral defects, a thorough analysis is necessary. After reviewing the available literature, it is clear that the method discussed for the correction of CBS is an excellent option. In addition to being cost-effective and simple, it has a high success rate with a positive prognosis, especially in cases of medium and large defects.
A TRANSMISSIBILIDADE DOS BENS DIGITAIS SOB A ÓTICA DOS DIREITOS PERSONALÍSSIMOS.
Authors: Aquino Alice Maria Silva de , Guimarães Grazielly dos Anjos Fontes
Published: August 2024

This work deals with the possibility of digital assets being transferable, taking into account the fundamental right to inheritance and personal rights. To this end, it discusses the types of digital assets and the need for their protection in the Brazilian legal system. In this context, the article discusses the classical civilist and constitutionalist view of the succession of digital assets, with a view to the interests of the deceased and their heirs. Additionally, the various interpretations of the transmission of digital inheritance by the Courts of Justice, higher courts, international standards and decisions are mentioned. Furthermore, the current legislative scenario of digital inheritance in Brazil is mentioned, as well as alternative ways to ensure the transmission of assets and the realization of the will of the rights holder.
EPIDEMIOLOGIA E FATORES DE RISCO NA SÍNDROME DE TOURETTE: UMA REVISÃO INTEGRATIVA
Authors: Follman Ana Letícia , Botelho Arthur , Gomes Bianca , Souza Caio Henrique , da Silva Elissandro , Mombach Felipe José , de Souza Francimara , de Almeida Francisca Carla , Lima Jair Felipe , Thomé Janaina Luiza , Rosa Jennyffer , de Abreu João Vitor , Carvalho Luiz Eduardo , Silio Luiz Gustavo , Teodoro Vinicius José
Published: August 2024

Tourette Syndrome (TS) is a neurological disorder characterized by persistent motor and vocal tics, often accompanied by comorbid conditions such as Obsessive-Compulsive Disorder (OCD) and Attention-Deficit/Hyperactivity Disorder (ADHD). This integrative review addresses the epidemiology and risk factors associated with TS, drawing on recent and seminal studies in the field. Prevalence estimates for TS reach up to 1% of the general population, as evidenced by Tanner (1993) and Apter et al. (1993), with variations attributed to factors such as increased public awareness and diagnostic advancements. Genetic factors, as demonstrated by Pauls and Leckman (1988) and Eapen et al. (1993), play a significant role in TS predisposition, while neurobiological, environmental, and psychosocial factors also influence the development of the syndrome. Understanding these factors is crucial for early diagnosis and effective management of TS. The comorbidity section explores the relationship of TS with OCD and ADHD, highlighting the need for integrated therapeutic approaches. Future directions include deepening the understanding of underlying mechanisms, exploring new treatments, and improving diagnostic and treatment access.
TOXICIDADE CARDÍACA NO TRATAMENTO DO CÂNCER DE MAMA HER2 POSITIVO COM ANTICORPO MONOCLONAL TRANSTUZUMABE: UMA REVISÃO SISTEMÁTICA
Authors: Moreira Samara Ribeiro , Lima Carolyne Vilarinho , Milhomem João Victor Braga , Veloso Amanda Teixeira , de Souza Areta Agostinho Rodrigues
Published: August 2024

O câncer de mama representa a principal forma de neoplasia entre mulheres globalmente, com cerca de 20% dos casos apresentando o subtipo molecular caracterizado pela superexpressão de HER2. Este estudo visa investigar o impacto da terapia antineoplásica com o anticorpo monoclonal trastuzumabe, focando no aumento da sobrevida livre de doença e nos riscos associados, especialmente a cardiotoxicidade manifestada pela diminuição da fração de ejeção do ventrículo esquerdo (FEVE) e insuficiência cardíaca congestiva (ICC). Através de uma revisão sistemática da literatura, conforme os critérios do modelo Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), foram consultadas bases de dados como Pubmed, Lilacs, BioOne, The Cochrane Library, Scielo, IBECS e Medline. Os resultados apontam para uma prevalência da redução da FEVE durante o tratamento com trastuzumabe, particularmente em pacientes com fatores de risco pré-existentes como uso prévio de antraciclinas, diabetes, hipertensão arterial sistêmica e histórico de cardiopatias. Conclui-se que, apesar dos riscos de cardiotoxicidade, as estratégias de monitoramento cardíaco e o uso de medicações cardioprotetoras mostram-se eficazes, com os benefícios do tratamento superando os riscos cardiovasculares. Este achado sublinha a importância de uma avaliação cuidadosa dos pacientes antes e durante a terapia com trastuzumabe para otimizar os resultados clínicos e minimizar os riscos.
Hukum Kepemilikan Sisa Kain Jahitan
Authors: Fikri Al Munawwar Sirait  , Dhiauddin Tanjung
Published: August 2024

This study aims to examine the concept of ownership from the perspective of Fiqh Muamalah, particularly in the context of human social relationships and daily life practices, such as the making of clothing by tailors. The method used in this research is an in-depth literature review, referring to various sources of Islamic law and the opinions of fuqaha (Islamic jurists) regarding ownership and its division. The results of the study indicate that ownership in Islam includes the rights to an object and its benefits, and can be divided into complete and incomplete ownership. Additionally, this research reveals the importance of tailors returning leftover fabric to the customer as a form of respect for ownership rights. The contribution of this study is to provide a clearer understanding of the importance of managing ownership in societal life, as well as to offer practical guidance for tailors in fulfilling their obligations to customers in accordance with the principles of Fiqh Muamalah
PERAN DAN DAMPAK PENGGUNAAN INOVASI FINANCIAL TECHNOLOGI (FINTECH) DALAM PENGEMBANGAN USAHA COFFEE SHOP DI KECAMATAN SAMBAS
Authors: Lailatul Mukaromah Lailatul , Abu Shama  , Munandar  , EE Zurmansyah
Published: August 2024

Pengkajian ini dilakukan  untuk mengetahui tingkat penggunaan Financial Technology terhadap UMKM di Kecamatan Sambas. Sampel dalam penelitian ini adalah Coffee Shop Habitat.co, Elc.coffee, dan Ullu Coffee. Teknik pengumpulan  data dilakukan dengan obeservasi, interview (wawancara), dan dokumentasi. Sedangkan metode yang digunakan yaitu metode analisi kualitatif deskriptif yang dilakukan dengan cara mendeskriptifkan data dalam bentuk kalimat yang mudah dipahami. Hasil dari penelitian ini menunjukkan bahwa penggunaan Financial Technology di coffee shop Habitat.co, Elc.coffee, dan Ullu Coffee menggunakan digital payment atau pembayaran online, pelaporan menggunakan aplikasi, serta melakukan pemasaran produk menggunakan media sosial. Penggunaannya yang sederhana dan simpel, jika mempraktikkan fintech pada bisnis UMKM yang dijalnkan, transaksi yang dilakukan akan dirasa lebih efektif dan dapat dilaksanakan dimana saja. Penggunaan aplikasi pada usahan ke 3 coffee shop tersebut adalah aplikasi Qasir yang digunakan oleh coffee Elc.coffee dan Ullu Coffee, sedangkan aplikasi Majoo digunakan oleh cafe Habitat.co. ketiga coffee shop tersebut menggunkan pembayran online seperti Qris, M-banking, Shopeepay dan Dana. Pemasasaran produk mereka memangfaatkan sosial media seperti instagram dan facebook. Penggunaan Fintech memberikan dampak pada usaha mereka, karena proses transaksi yang mudah dilakukan. Ada juga kesulitan dalam menggunakan Fintech ini adalah gangguan jaringan data seluler saat melakukan pembayaran online, terdapat fitur-fitur baru dari aplikasi yang digunakan dan belum dijelaskan oleh aplikasi tersebut membuat pengguna harus belajar mengetahui fiturfitur tersebut, dan terdapat kekhawatiran akan adanya kejahatan cyber ( mencuri data penting kode pin pada akun keuangan).
PERAN MEDIA SOSIAL DALAM MENINGKATKAN JUMLAH KUNJUNGAN EKSIBISI INVESTASI BOGORFEST DI KABUPATEN BOGOR
Authors: Noorhayati Susanti , Budianto Irawan RD
Published: August 2024

ABSTRACT
This research aims to determine the role of social media, especially Whatsapp, Facebook and Instagram, which are used as a means to promote the implementation of the Bogorfest investment exhibition by the Regional Government of Bogor Regency with the Leading Sector of the Bogor Regency Investment and One-Stop Integrated Services Service (DPMPTSP) in collaboration with government organizations. other areas.
Bogor Regency has economic resources and natural resources that are potential for investment activities. It is very important for the community and related parties, especially the business world, to know complete and complete information on investment potential in Bogor Regency. As one of the strategies to promote Bogor, Bogor Regency uses events as strategic promotional media packaged in Bogorfest activities to showcase investment potential so that regional advantages can be known by the public, especially the business world from all sectors such as trade, agriculture, animal husbandry, industry, as well as various service. It is hoped that the participation of the business world in this event or exhibition will attract potential investors from domestic and foreign investors to invest in Bogor Regency. The increasing investment graph in Bogor Regency is influenced by the image of Bogor Regency which is good and ready to open itself to investors.
PEMBERDAYAAN SENI KEBUDAYAAN MELALUI ALOKASI DANA HIBAH: STUDI KASUS IMPLEMENTASI OLEH DINAS PARIWISATA BONDOWOSO
Authors: . Suprianik , Basri Sefia Irhami , Nasiroh Holifatun , Nisaq Siti Fatimah Khoirun
Published: August 2024

ABSTRAK 
Penelitian ini bertujuan untuk menginvestigasi implementasi alokasi dana hibah dalam pengadaan alat musik seni kebudayaan oleh Dinas Pariwisata, Kebudayaan, Pemuda, dan Olahraga (DISPARBUDPORA) Kabupaten Bondowoso. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan fokus pada pemahaman mendalam tentang proses alokasi dan penggunaan dana hibah. Lokasi penelitian adalah Kabupaten Bondowoso, Jawa Timur, Indonesia, dengan subjek penelitian meliputi pihak DISPARBUDPORA, kelompok seni, dan penerima manfaat langsung dari alokasi dana hibah. Hasil penelitian menunjukkan bahwa alokasi dana hibah bertujuan utama untuk melestarikan dan mengembangkan seni kebudayaan, khususnya melalui pengadaan alat musik bagi kelompok seni yang sudah memiliki sejarah yang cukup. Dana hibah berasal dari Anggaran Pendapatan dan Belanja Daerah (APBD) Kabupaten Bondowoso, dengan pengelolaan dan pelaksanaan yang diserahkan kepada DISPARBUDPORA. Proses pengajuan dana hibah melibatkan berbagai tahapan, termasuk penyusunan proposal dan evaluasi oleh pihak berwenang. Alokasi dana hibah diarahkan untuk mendukung pemeliharaan, pengembangan, dan promosi alat musik tradisional, dengan langkah-langkah pelaksanaan dan penatausahaan yang terdefinisi dengan baik. Monitoring dan evaluasi dilakukan oleh SKPD terkait untuk memastikan penggunaan dana hibah sesuai dengan tujuan yang diinginkan. Penelitian ini memberikan pemahaman yang mendalam tentang peran alokasi dana hibah dalam mendukung keberlanjutan seni kebudayaan di Kabupaten Bondowoso, serta implikasinya dalam pengelolaan sumber daya keuangan daerah untuk mendukung sektor-sektor budaya.
ANALISIS REKONSILIASI PPN UNTUK PELAPORAN SPT MASA PPN PADA KOPKAR PT VUB
Authors: Handayani Rukmining Tias Niken , Tannar Oryza
Published: August 2024

Tujuan dari penelitian ini adalah untuk mengetahui penyelesaian rekonsiliasi dengan SPT Laporan Keuangan Perusahan pada Kopkar PT VUB. Rekonsiliasi diperlukan untuk mengetahui perbedaan nilai PPN terutang yang harus dibayarkan oleh Kopkar PT VUB sebelum dibayarkan pada Lampiran SPT Masa PPN. Dengan dilakukannya rekonsiliasi setiap masa PPN perusahaan dapat menghindari kekurangan ataupun kelebihan bayar pada saat melakukan pembayaran SPT Masa PPN. Penelitian ini menggunakan teknik analisis deskriptif kualitatif dalam metode analisis tingkat keseimbangan antara pelaporan keuangan dan PPN yang dilaporkan ke spt. Sumber data diperoleh dari studi dokumen, wawancara dan literatur. Hasil penelitian ini menunjukkan perbedaan jumlah PPN final yang dibayarkan antara SPT dengan laporan keuangan PT VUB Kopkar. Tetapi masih terbatas pada jumlah yang wajar dari angka yang dapat diterima.
CIRURGIA ABDOMINAL POR ROBÓTICA: AVALIAÇÃO DA EXPERIÊNCIA BRASILEIRA INICIAL
Authors: Vargas Bárbara Citelis Silva , Cabral Yago Arthur Domingos , Silva Ian Isaias Paes landim Ribeiro da , Nogueira Marcos Gustavo Batista , Saraiva Ana Flávia Fernandes , Vieira Ananda Cordeiro , Madeira Wellington dos Santos , Souza Lucas dos Santos de , Leal Ana Letícia Maria Lins , Mota Rodrigo Miranda , Rocha Giovanni Rodrigues Moraes , Hernandes Christian Fricks , Perez Gabriel Barreto , Soares Andrezza Fagundes , Linhares Eduarda Ozório Nunes Nogueira , Santos Ivana Maria Herenio Dos , Santos Filho João Antônio dos , Neres Keliane Almeida , Cipriano Larissa Rêgo
Published: August 2024

Introdução: A cirurgia abdominal robótica tem emergido como um avanço significativo na prática cirúrgica no Brasil, destacando-se pela precisão aprimorada, menor invasividade e recuperação acelerada para os pacientes. Objetivo: Este estudo avalia a experiência inicial brasileira com a cirurgia robótica abdominal, focando nos benefícios, desafios e resultados preliminares. Metodologia: Utilizando uma abordagem de revisão narrativa, foram analisados artigos publicados entre 2010 e 2024, extraídos das bases de dados PubMed, Scielo e Google Scholar, que descrevem a implementação e os resultados clínicos da tecnologia no contexto brasileiro. Resultados mostram que a cirurgia robótica tem oferecido vantagens substanciais, como redução do tempo de  recuperação e menor incidência de complicações pós-operatórias em comparação com métodos tradicionais. No entanto, desafios como o elevado custo dos equipamentos e a necessidade de treinamento especializado foram identificados como barreiras significativas para uma adoção mais ampla. Apesar dos benefícios, a expansão da tecnologia enfrenta obstáculos econômicos e logísticos que devem ser superados para garantir uma adoção mais equitativa. Discussão: Os achados corroboram com aliteratura internacional, evidenciando que os benefícios observados no Brasil são consistentes com os resultados globais. No entanto, é essencial realizar mais estudos para avaliar o custo-benefício da cirurgia robótica a longo prazo e explorar soluções que possam reduzir os custos e melhorar a acessibilidade. Conclusão: a experiência inicial com a cirurgia robótica abdominal no Brasil é promissora, com potencial para melhorar os resultados cirúrgicos e a recuperação dos pacientes, mas requer a superação de desafios econômicos e logísticos para uma expansão efetiva.
SUPLEMENTAÇÃO DE ZINCO NA PREVENÇÃO E MANEJO DE DIARREIA EM CRIANÇAS: UMA REVISÃO DE LITERATURA
Authors: Lima Julia Hammerschlag , Cova Maria Cecília Carvalho da , Vicente Apolyana Peres Martelleto , Silva Luane Godinho Carino da , Costa Handella Vitória Coelho Carneiro , Simão Ana Letícia Corvisier Sad , Gomes Lucas de Souza , Goldfeld Eduarda Parrilha , Paresqui Lara , Moura Dávinna Nyara Lima , Lima Cassio Vinicius Rodrigues de , Packer Rebecca Christophoro , Lauriano Isadora Machado , Nunes Caio Meireles , Dantas Lucas Alves , Monteiro Manoella Manhães , Vasconcelos Pablo Vinícius Silvino , Braga Roberta de Oliveira
Published: August 2024

Introdução: A suplementação de zinco mostra-se promissora no manejo e prevenção da diarreia infantil, uma condição de grande impacto global, especialmente em regiões com recursos limitados. Este mineral desempenha um papel crucial na função imunológica e na integridade da mucosa intestinal, essencial para a recuperação rápida durante episódios de diarreia aguda. A revisão foca em explorar os benefícios potenciais da suplementação de zinco, abordando lacunas críticas em sua eficácia, especialmente em contextos de países em desenvolvimento. Objetivo: Determinar a eficácia da suplementação de zinco na prevenção e manejo da diarreia em crianças. Métodos: Uma revisão sistemática de literatura foi realizada nas bases de dados Pubmed e Scopus, com um filtro de 5 anos e estudos de alta qualidade metodológica em língua inglesa. Resultados e discussão: Foram selecionados 7 artigos para compor essa pesquisa. A discussão sobre a suplementação de zinco na gestão da diarreia infantil revela resultados heterogêneos entre os estudos analisados. Enquanto alguns encontram benefícios significativos na redução da gravidade e duração dos episódios diarreicos, outros questionam a eficácia universal dessa intervenção. Estudos destacam quedoses menores de zinco podem ser tão eficazes quanto doses padrão, mas a eficácia varia com fatores como idade da criança e contexto nutricional. Conclusão: A suplementação de zinco mostra potencial na redução da morbidade por diarreia em crianças, mas os resultados variados destacam a necessidade de mais pesquisas para estabelecer diretrizes claras. Em suma, é uma estratégia promissora para melhorar a saúde infantil global, e exige uma abordagem adaptativa e baseada em evidências para otimizarseus benefícios.
Pioneering Interactive Learning: Enhancing Al-Istima' Skills in 10th Grade Madrasah Aliyah with iSpring Suite 9 Educational Media Development
Authors:   Arabic Education Study Program, UIN Raden Intan Lampung(Indonesia), Nurjanah Latief , Ridlo Abdullah ,   Islamic   religious   education, Institut   Agama   Islam   Imam   Al-Ghozali, (Indonesia)
Published: August 2024

This research aims to develop interactive learning media using iSpring Suite 9 for maharah al-istima’ (listening skill) in class X of Madrasah Aliyah. This learning media is designed to facilitate the teaching and learning process for both teachers and students in maharah al-istima’ subject. The use of interactive learning media with iSpring Suite 9 has significantly increased students' enthusiasm in the learning process and successfully captured their interest in learning. The research follows a development approach based on Sugiyono's model with seven stages, namely potential and problem analysis, data collection, product design, design validation, design revision, product testing, and final product revision. The validation process involved assessments from 2 subject matter experts, 2 design and media experts, as well as feedback from teachers and students. Small-scale testing was conducted with a group of 15 students, followed by field testing involving 42 students of class X at MA Assyifa Karang Sari in South Lampung. The research findings indicate that interactive learning media using iSpring Suite 9 for maharah al-istima’ in class X of Madrasah Aliyah achieved an average percentage of 85% from the assessment by subject matter experts (categorized as highly feasible), 92% from design and media experts' assessment (categorized as highly feasible), 83% from small-scale testing (categorized as very interesting), and 83% from field testing (categorized as very interesting). In conclusion, the utilization of iSpring Suite 9 for interactive learning in maharah al-istima’ subject for class X of Madrasah Aliyah is highly recommended due to its practicality and user-friendly features.
Development of Arabic Interactive Learning Media Assisted by Kodular for Grade VIII at Islamic Junior High School
Authors:   Arabic Education Study Program, Universitas Islam Negeri Raden Intan Lampung(Indonesia), Wicaksana M. Tegar , Erlina Erlina ,   Arabic Education Study Program, Universitas Islam Negeri Raden Intan Lampung(Indonesia)
Published: August 2024

This research is a research and development of interactive learning media in Arabic with codular assistance for class VIII of Madrasah Tsanawiyah. This study aims to find out how the development, feasibility, student responses and effectiveness of codular-assisted Arabic interactive learning media. This research method is research and development (R&D) based on a 4D model consisting of definition, design, development and dissemination. Before media is used, it is verified by two media and material experts. Subjects of this study were class VIII students of MTs Guppi 2 Tanjung Karang (maximum 20 students) and MTs NU Tanjung Karang (maximum 20 students). Survey data were obtained through interview techniques, questionnaires, tests and documentation. Rating results based on the Media Expert Validation Questionnaire for this Cordura-based Arabic interactive learning media are in the valid category with a decent category average score of 98%. The material expert's assessment of this codular-assisted Arabic interactive learning media obtained an average score of 98% with a decent category. Based on calculations using the t-test, researchers obtained the results of research data in MTs Guppi 2 Tanjung Karang with a value = 12.55 and a value = 1.27 at a significant level = 0.05 with the results of the comparison with is 12.55>1.27. Then the researchers obtained the results of research data at MTs NU Tanjung Karang with a value = 10.38 and a value = 2.88 at a significant level = 0.05 with the results of a comparison with is 10.38>2.88. The results of the two research data showed significant results between before using learning media and after using learning media. So by looking at the results above, this codular-assisted Arabic interactive learning media has shown high effectiveness in improving student learning outcomes.
Enhancing Arabic Vocabulary Mastery through Digital Literacy: Overcoming Challenges and Implementing Effective Strategies
Authors: Subkhi Muhammad , Haning Tyas Divara Aulia
Published: August 2024

This study explores the implementation of digital literacy-based learning strategies in Arabic vocabulary (mufrodat) education, aiming to enhance students' comprehension and proficiency. Despite its potential, several challenges impede effective application, including limited access to technology and infrastructure, inadequate digital literacy skills, insufficient authentic assessment methods, and lack of support and guidance from educators. To address these challenges, this study recommends improving technological access and infrastructure, enhancing digital literacy skills through targeted training and workshops, developing authentic assessment methods, and providing comprehensive support and guidance for teachers. The implementation of these solutions necessitates collaboration among government bodies, educational institutions, teachers, and students. This research significantly contributes to the field of Arabic language education by integrating digital literacy, thereby enhancing the overall quality of education. The findings provide valuable insights for educators in designing effective learning strategies, for policymakers in formulating supportive educational policies, and for researchers in conducting further studies on digital literacy and Arabic language learning. The study underscores the importance of digital literacy in modern education and its role in fostering improved learning outcomes.
Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights
Authors: Willbrand Ethan H , Tsai Yi-Heng , Gagnant Thomas , Weiner Kevin S
Published: August 2024

Recent work has uncovered relationships between evolutionarily new small and shallow cerebral indentations, or sulci, and human behavior. Yet, this relationship remains unexplored in the lateral parietal cortex (LPC) and the lateral parieto-occipital junction (LPOJ). After defining thousands of sulci in a young adult cohort, we revised the previous LPC/LPOJ sulcal landscape to include four previously overlooked, small, shallow, and variable sulci. One of these sulci (ventral supralateral occipital sulcus, slocs-v) is present in nearly every hemisphere and is morphologically, architecturally, and functionally dissociable from neighboring sulci. A data-driven, model-based approach, relating sulcal depth to behavior further revealed that the morphology of only a subset of LPC/LPOJ sulci, including the slocs-v, is related to performance on a spatial orientation task. Our findings build on classic neuroanatomical theories and identify new neuroanatomical targets for future “precision imaging” studies exploring the relationship among brain structure, brain function, and cognitive abilities in individual participants.
OpenNucleome for high-resolution nuclear structural and dynamical modeling
Authors: Lao Zhuohan , Kamat Kartik D , Jiang Zhongling , Zhang Bin
Published: August 2024

The intricate structural organization of the human nucleus is fundamental to cellular function and gene regulation. Recent advancements in experimental techniques, including high-throughput sequencing and microscopy, have provided valuable insights into nuclear organization. Computational modeling has played significant roles in interpreting experimental observations by reconstructing high-resolution structural ensembles and uncovering organization principles. However, the absence of standardized modeling tools poses challenges for furthering nuclear investigations. We present OpenNucleome—an open-source software designed for conducting GPU-accelerated molecular dynamics simulations of the human nucleus. OpenNucleome offers particle-based representations of chromosomes at a resolution of 100 KB, encompassing nuclear lamina, nucleoli, and speckles. This software furnishes highly accurate structural models of nuclear architecture, affording the means for dynamic simulations of condensate formation, fusion, and exploration of non-equilibrium effects. We applied OpenNucleome to uncover the mechanisms driving the emergence of ‘fixed points’ within the nucleus—signifying genomic loci robustly anchored in proximity to specific nuclear bodies for functional purposes. This anchoring remains resilient even amidst significant fluctuations in chromosome radial positions and nuclear shapes within individual cells. Our findings lend support to a nuclear zoning model that elucidates genome functionality. We anticipate OpenNucleome to serve as a valuable tool for nuclear investigations, streamlining mechanistic explorations and enhancing the interpretation of experimental observations.
Exploring the role of the immune microenvironment in hepatocellular carcinoma: Implications for immunotherapy and drug resistance
Authors: Fu Yumin , Guo Xinyu , Sun Linmao , Cui Tianming , Wu Chenghui , Wang Jiabei , Liu Yao , Liu Lianxin
Published: August 2024

Hepatocellular carcinoma (HCC), the most common type of liver tumor, is a leading cause of cancer-related deaths, and the incidence of liver cancer is still increasing worldwide. Curative hepatectomy or liver transplantation is only indicated for a small population of patients with early-stage HCC. However, most patients with HCC are not candidates for radical resection due to disease progression, leading to the choice of the conventional tyrosine kinase inhibitor drug sorafenib as first-line treatment. In the past few years, immunotherapy, mainly immune checkpoint inhibitors (ICIs), has revolutionized the clinical strategy for HCC. Combination therapy with ICIs has proven more effective than sorafenib, and clinical trials have been conducted to apply these therapies to patients. Despite significant progress in immunotherapy, the molecular mechanisms behind it remain unclear, and immune resistance is often challenging to overcome. Several studies have pointed out that the complex intercellular communication network in the immune microenvironment of HCC regulates tumor escape and drug resistance to immune response. This underscores the urgent need to analyze the immune microenvironment of HCC. This review describes the immunosuppressive cell populations in the immune microenvironment of HCC, as well as the related clinical trials, aiming to provide insights for the next generation of precision immunotherapy.
Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation
Authors: Pahl Matthew C , Sharma Prabhat , Thomas Rajan M , Thompson Zachary , Mount Zachary , Pippin James , Morawski Peter A , Sun Peng , Su Chun , Campbell Daniel J , Grant Struan FA , Wells Andrew D
Published: August 2024

Genome-wide association studies (GWAS) have identified hundreds of genetic signals associated with autoimmune disease. The majority of these signals are located in non-coding regions and likely impact
cis
-regulatory elements (cRE). Because cRE function is dynamic across cell types and states, profiling the epigenetic status of cRE across physiological processes is necessary to characterize the molecular mechanisms by which autoimmune variants contribute to disease risk. We localized risk variants from 15 autoimmune GWAS to cRE active during TCR-CD28 costimulation of naïve human CD4+ T cells. To characterize how dynamic changes in gene expression correlate with cRE activity, we measured transcript levels, chromatin accessibility, and promoter-cRE contacts across three phases of naive CD4+ T cell activation using RNA-seq, ATAC-seq, and HiC. We identified ∼1,200 protein-coding genes physically connected to accessible disease-associated variants at 423 GWAS signals, at least one-third of which are dynamically regulated by activation. From these maps, we functionally validated a novel stretch of evolutionarily conserved intergenic enhancers whose activity is required for activation-induced
IL2
gene expression in human and mouse, and is influenced by autoimmune-associated genetic variation. The set of genes implicated by this approach are enriched for genes controlling CD4+ T cell function and genes involved in human inborn errors of immunity, and we pharmacologically validated eight implicated genes as novel regulators of T cell activation. These studies directly show how autoimmune variants and the genes they regulate influence processes involved in CD4+ T cell proliferation and activation.
Social Networks
Authors: Barnett George A.
Published: February 2015

This entry provides a brief introduction to the topic of social and communication networks and their analysis. It then discusses specific applications to the study of digital social/communication networks using a two‐dimensional typology for the organization of network studies of digital networks. One dimension is the size or scope of the examined network and the nodes that compose the examined system; the other dimension is the channel or mechanism that links the various actors.
Digital Divide(s)
Authors: Hilbert Martin
Published: February 2015

The digital divide refers to an inequality in the access to, use, and impact of digital information and communication technology (ICT) among social agents. Research on this social inequality has evolved around the questions of who, with which attributes, connects how to what kind of ICT. Different foci on these questions lead to different answers about the closing or widening nature of the divide. Digital inequality has evolved beyond a binary distinction between “have” and “have not,” becoming a question of “more” versus “less” that evolves with the incessant innovation of ICT. The digital divide is not merely a technological, but a social challenge, and the key question of how to tackle it hinges on the context‐dependent issue of the expected social benefit achieved by ICT. Since the potential applications of ICT are diverse, the strategies aimed at tackling these diverse challenges must be diverse as well.
Environmental Issues
Authors: Cramer Benjamin W.
Published: February 2015

In nations with environmental protection laws, the enforcement of those laws often depends on the creation and management of information. That information is found in a variety of documents that is ultimately held by governmental entities, and ranges from environmental assessments, to permits, to lists of toxic substances. Although the existence of such documents cannot guarantee environmental protection, when citizens become aware of the presence of so much government‐held environmental information, they seek documents of interest in order to check the performance of their leaders and to assess the environmental health of their communities. This desire for government‐held documents has resulted in access and transparency provisions in many environmental laws around the world.
Mobile Social Networks
Authors: Humphreys Lee
Published: February 2015

Mobile social networks are services accessed through mobile devices that enable users to connect with others and share information, images, content, and news. Early mobile social networks began in the late 1990s and facilitate social interaction in public spaces. Research on mobile social networks draws primarily on media sociology, critical theory of media, and design studies. Key tensions addressed in mobile social network research surround sociality, sense of place, and privacy. Topical areas of research on mobile social networks focus on social identity and collective action, pervasive computing, and gaming. Future areas for development and exploration include the combining of interpersonal communication and media theories, commercialization of data and networks, historical comparisons, and privacy.
Open Source Software in the Global South
Authors: De' Rahul
Published: February 2015

For users of information technology (IT), Free and open source software (FOSS) is a powerful alternative to proprietary software. It enables easy and low‐cost access to high‐quality software, making it valuable for individuals and organizations in countries of the global South. Organizations such as government departments, large companies, small and medium enterprises, and educational institutions have adopted FOSS to great benefit. This benefit derives from immediate costs savings and from long‐term advantages of enhanced skills, entrepreneurial innovations, reduced dependence, and enhanced security.
e
‐Commerce and Online Security
Authors: Hanus Bartlomiej , Kim Dan J.
Published: February 2015

This article provides an overview of the components and entities involved in the formation of electronic commerce information security: buyers, sellers, third parties, and technology. It discusses key characteristics of each entity and the interactions between these entities from the perspective of potential information security issues. In addition, it presents a mixture of possible results of such interrelationships and their impact on the consequences of e‐commerce transactions. Finally, the emerging threats of mobile electronic commerce are discussed, followed by a suggested research model.
Social Media in Politics
Authors: Anstead Nick
Published: February 2015

The relationship between social media and political life is the subject of much academic research and debate. After a discussion of contextual issues, this entry focuses on three areas: the relationship between traditional political institutions and social media; the role played by social media in contemporary activism and in social movement politics; and research on social media effects on citizens' political behavior and knowledge. It concludes with a discussion of skeptical views about the potential of social media to change politics, as well as identifying research challenges for the future.
Online Games Player Characteristics
Authors: Jansz Jeroen , Neys Joyce
Published: February 2015

In the past the image of a gamer was of a somewhat nerdy male teenager playing alone in a basement. Since then, the average gamer has grown a little older, gained a little weight, grown a ponytail, and can be seen surrounded by pizza boxes while enjoying an incomprehensible social life online. One thing that has not changed much over the years is that today's online gamer is still male in the public's eye. Stereotypes tend to be resistant to change and may even have a kernel of truth, but they also need to be scrutinized critically. This entry investigates who online gamers are and why they play.
e
‐Commerce Reputation Systems
Authors: Wierzbicki Adam , Adamska Paulina
Published: February 2015

In online and virtual world settings, an individual may often interact with unfamiliar individuals and entities. Therefore reputation has become a crucial concept for many social and commercial interactions because it can facilitate decision support in such situations. In this entry we present a brief overview of existing reputation system designs, along with a discussion of the common methods of gaming such systems, and review some of latest research findings in this area.
Media Diversity Law and Regulation
Authors: Hitchens Lesley
Published: February 2015

This entry provides an overview of the media diversity concept and examples of some of the policy and regulatory tools adopted to promote media diversity. It considers whether the advent of the digital environment heralds the end of the need for such policies.
Netnography
Authors: Kozinets Robert V.
Published: February 2015

Netnography is a specific approach to conducting ethnography on the internet. It is a qualitative, interpretive research methodology that adapts traditional ethnographic techniques to the study of social media. As discussed in this entry, Netnography adds specific practices that include locating communities and topics, narrowing data, handling large digital datasets, analyzing digitally contextualized data, and navigating difficult online ethical matters and research procedures. The nature of researcher immersion and ethnographic (or “netnographic”) participation is also treated rigorously within netnography. The new approach has gained wide acceptance within business research and is spreading to other fields.
Social Media
Authors: van der Graaf Shenja
Published: February 2015

Over the past decade, social media has become a widely used umbrella term that refers to the set of tools, applications, and services that enable people to interact with others using network technologies such as personal computers and smartphones. Social media tends to be associated with a convergence of production, distribution, and consumption practices and a blending of user creativity, collaboration, and sharing enabled and sharing assisted network technologies. In this way, social media is said to have deeply penetrated into the mechanics of everyday life, affecting people's interactions, institutional structures and professional routines. This entry offers an inclusive perspective of the “fabric of social media,” which underpins understandings of both social and media. In particular, it highlights the dynamics of empowerment, always‐on lifestyle, and professionalization.
Social Media Ethics
Authors: van Leeuwen Marco
Published: February 2015

Social media has greatly expanded our connectedness, capitalizing upon one of the defining features of the internet: the incredible potential for connectivity both in terms of social relations (connecting people) and in terms of information (providing access to huge amounts of data by opening up and combining databases). Both of these aspects are ethically significant. This entry explores several ethically relevant aspects of social media and its use, its influence on personality and on cognitive performance, and the problematic status of intellectual property and privacy. In addition, attention is drawn to the ethical styles that are most naturally expressed in social media behavior.
Social Media and Relationships
Authors: Butler Brian S. , Matook Sabine
Published: February 2015

This entry focuses on the ways in which social media systems are affected by and affect relationships. No matter what the underlying technology, the power of social media systems arises from the impact they have on relationships. Whether in friendship and dating relationships or professional and work relationships, social media use shapes and is shaped by how individuals see their relationships, who they have relationships with, and how those relationships are formed, maintained, and ended.
Online Labor and Business Outsourcing
Authors: Free Alex
Published: February 2015

Online labor and business outsourcing encompass the practice of fulfilling a range of activities and roles outside conventional organizational and company structures. As part of a progressively more interconnected global economy and the rise of new media technological capabilities, organizations enter into various forms of relationship with external actors in order to focus on their own core competencies and specialisms, to access new forms of creativity, and to cut costs. In offering the potential to alter global processes and relations of production and to create new avenues for growth and revenue generation, such arrangements present both opportunities and challenges for actors concerned with international development and global inequalities in relation to wealth, technology, and access to markets. Forms of online labor reflect various organizational objectives, such as customer oriented commercial crowdsourcing in which companies seek to capture customer tastes and integrate labor input as part of the co‐production and value‐creation process, while business outsourcing harnesses new media technologies to externalize back‐office and front‐office tasks, such as through microwork projects or more established commercial arrangements.
ICT4D
and Economic Development
Authors: Souter David
Published: February 2015

This entry describes understanding and perceptions of the relationship between information and communication technologies (ICTs), economic growth, and economic development. The first section is concerned with the impact of ICTs on the world economy and development in general. The second focuses on the impact of economic growth as measured by macroeconomic outcomes. The third discusses the relationship between ICTs and three types of economic activity: established economic sectors, including trade; the ICT and ICT enabled sectors; and small and micro‐businesses. The final section considers policy implications.