bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitis vinifera (Vine Grape) as a Valuable Cosmetic Raw Material
Authors: Sharafan Marta , Malinowska Magdalena A. , Ekiert Halina , Kwaśniak Beata , Sikora Elżbieta , Szopa Agnieszka
Published: May 2023

This review refers to botanical, ecological and phytochemical characteristics of Vitis vinifera L. (vine grape)–a species, the valuable properties of which are widely exploited in the food industry and in recent times in medicine as well as in phytocosmetology. The general characteristic of V. vinifera, followed by the chemical composition and biological activities of different extracts obtained from the plant (fruit, skin, pomace, seed, leaf and stem extracts), are provided. A concise review of the extraction conditions of grape metabolites and the methods of their analysis are also presented. The biological activity of V. vinifera is determined by the presence of high contents of polyphenols, mainly flavonoids (e.g., quercetin, kaempferol), catechin derivatives, anthocyanins and stilbenoids (e.g., trans-resveratrol, trans-ε-viniferin). The review pays particular attention to the application of V. vinifera in cosmetology. It has been proven that V. vinifera possesses strong cosmetological-related properties, such as anti-ageing properties, anti-inflammatory properties and skin-whitening properties. Moreover, a review of studies on V. vinifera biological activities, which are of particular interest for dermatologic problems, are disclosed. Furthermore, the work also emphasises the importance of biotechnological studies on V. vinifera. The last part of the review is addressed to the safety of the use of V. vinifera.
MiR-126-Loaded Immunoliposomes against Vascular Endothelial Inflammation In Vitro and Vivo Evaluation
Authors: Tang Yongyu , Chen Ying , Guo Qianqian , Zhang Lidan , Liu Huanhuan , Wang Sibu , Wu Xingjie , Shen Xiangchun , Tao Ling
Published: May 2023

Due to the accompaniment of vascular endothelial inflammation during the occurrence and development of cardiovascular diseases (CVD), treatment modalities against vascular endothelial inflammation have been intensively investigated for CVD prevention and/or treatment. Vascular cell adhesion molecule-1 (VCAM-1) is a typical transmembrane inflammatory protein specifically expressed by inflammatory vascular endothelial. By inhibiting VCAM-1 expression through the miR-126 mediated pathway, vascular endothelial inflammation can be efficiently relieved. Inspired by this, we developed a miR-126-loaded immunoliposome with VCAM-1 monoclonal antibody (VCAMab) decorated at its surface. This immunoliposome can be directly targeted to VCAM-1 at the inflammatory vascular endothelial membrane surface and achieve highly efficient treatment against inflammation response. The cellular experiment results showed the immunoliposome had a higher uptake rate towards inflammatory human vein endothelial cells (HUVECs) and can significantly downregulate the VCAM-1 expression level of inflammatory HUVECs. In vivo investigation further demonstrated that this immunoliposome displayed a higher accumulation rate at vascular inflammatory dysfunction sites than its non-VCAMab-modified counterpart. These results suggest that this novel nanoplatform can effectively deliver miR-126 to vascular inflammatory endothelium, opening a new avenue for the safe and effective delivery of miRNA for potential clinical application.
An Automated Customizable Live Web Crawler for Curation of Comparative Pharmacokinetic Data: An Intelligent Compilation of Research-Based Comprehensive Article Repository
Authors: Ampadi Ramachandran Remya , Tell Lisa A. , Rai Sidharth , Millagaha Gedara Nuwan Indika , Xu Xuan , Riviere Jim E. , Jaberi-Douraki Majid
Published: May 2023

Data curation has significant research implications irrespective of application areas. As most curated studies rely on databases for data extraction, the availability of data resources is extremely important. Taking a perspective from pharmacology, extracted data contribute to improved drug treatment outcomes and well-being but with some challenges. Considering available pharmacology literature, it is necessary to review articles and other scientific documents carefully. A typical method of accessing articles on journal websites is through long-established searches. In addition to being labor-intensive, this conventional approach often leads to incomplete-content downloads. This paper presents a new methodology with user-friendly models to accept search keywords according to the investigators’ research fields for metadata and full-text articles. To accomplish this, scientifically published records on the pharmacokinetics of drugs were extracted from several sources using our navigating tool called the Web Crawler for Pharmacokinetics (WCPK). The results of metadata extraction provided 74,867 publications for four drug classes. Full-text extractions performed with WCPK revealed that the system is highly competent, extracting over 97% of records. This model helps establish keyword-based article repositories, contributing to comprehensive databases for article curation projects. This paper also explains the procedures adopted to build the proposed customizable-live WCPK, from system design and development to deployment phases.
Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone
Authors: Soldatova Yuliya V. , Faingold Irina I. , Poletaeva Darya A. , Kozlov Alexei V. , Emel’yanova Nina S. , Khodos Igor I. , Chernyaev Dmitry A. , Kurmaz Svetlana V.
Published: May 2023

Water-soluble forms of α-tocopherol (TP) as an effective antioxidant were obtained by encapsulating it into nanoparticles (NPs) of amphiphilic copolymers of N-vinylpyrrolidone with triethylene glycol dimethacrylate (CPL1-TP) and N-vinylpyrrolidone with hexyl methacrylate and triethylene glycol dimethacrylate (CPL2-TP) synthesized by radical copolymerization in toluene. The hydrodynamic radii of NPs loaded with TP (3.7 wt% per copolymers) were typically ca. 50 or 80 nm depending on copolymer composition, media, and temperature. Characterization of NPs was accomplished by transmission electron microscopy (TEM), IR-, and 1H NMR spectroscopy. Quantum chemical modeling showed that TP molecules are capable to form hydrogen bonds with donor groups of the copolymer units. High antioxidant activity of both obtained forms of TP has been found by the thiobarbituric acid reactive species and chemiluminescence assays. CPL1-TP and CPL2-TP effectively inhibited the process of spontaneous lipid peroxidation as well as α-tocopherol itself. The IC50 values of luminol chemiluminescence inhibition were determined. Antiglycation activity against vesperlysine and pentosidine-like AGEs of TP water-soluble forms was shown. The developed NPs of TP are promising as materials with antioxidant and antiglycation activity and can be used in various biomedical applications.
Combination of Chemotherapy and Mild Hyperthermia Using Targeted Nanoparticles: A Potential Treatment Modality for Breast Cancer
Authors: Kaur Ishdeep , Tieu Terence , Deepagan Veerasikku G. , Ali Muhammad A. , Alsunaydih Fahad , Rudd David , Moghaddam Maliheh A. , Bourgeois Laure , Adams Timothy E. , Thurecht Kristofer J. , Yuce Mehmet , Cifuentes-Rius Anna , Voelcker Nicolas H.
Published: May 2023

Despite the clinical benefits that chemotherapeutics has had on the treatment of breast cancer, drug resistance remains one of the main obstacles to curative cancer therapy. Nanomedicines allow therapeutics to be more targeted and effective, resulting in enhanced treatment success, reduced side effects, and the possibility of minimising drug resistance by the co-delivery of therapeutic agents. Porous silicon nanoparticles (pSiNPs) have been established as efficient vectors for drug delivery. Their high surface area makes them an ideal carrier for the administration of multiple therapeutics, providing the means to apply multiple attacks to the tumour. Moreover, immobilising targeting ligands on the pSiNP surface helps direct them selectively to cancer cells, thereby reducing harm to normal tissues. Here, we engineered breast cancer-targeted pSiNPs co-loaded with an anticancer drug and gold nanoclusters (AuNCs). AuNCs have the capacity to induce hyperthermia when exposed to a radiofrequency field. Using monolayer and 3D cell cultures, we demonstrate that the cell-killing efficacy of combined hyperthermia and chemotherapy via targeted pSiNPs is 1.5-fold higher than applying monotherapy and 3.5-fold higher compared to using a nontargeted system with combined therapeutics. The results not only demonstrate targeted pSiNPs as a successful nanocarrier for combination therapy but also confirm it as a versatile platform with the potential to be used for personalised medicine.
Pharmacokinetic Feasibility of Stability-Enhanced Solid-State (SESS) Tenofovir Disoproxil Free Base Crystal
Authors: You Byoung Hoon , Bae Mingoo , Han Seung Yon , Jung Jieun , Jung Kiwon , Choi Young Hee
Published: May 2023

Tenofovir (TEV) is a nucleotide reverse transcriptase inhibitor used against human immunodeficiency virus (HIV) reverse transcriptase. To improve the poor bioavailability of TEV, TEV disoproxil (TD), an ester prodrug of TEV, was developed, and TD fumarate (TDF; Viread®) has been marketed due to the hydrolysis of TD in moisture. Recently, a stability-enhanced solid-state TD free base crystal (SESS-TD crystal) was developed with improved solubility (192% of TEV) under gastrointestinal pH condition and stability under accelerated conditions (40 °C, RH 75%) for 30 days. However, its pharmacokinetic property has not been evaluated yet. Therefore, this study aimed to evaluate the pharmacokinetic feasibility of SESS-TD crystal and to determine whether the pharmacokinetic profile of TEV remained unchanged when administering SESS-TD crystal stored for 12 months. In our results, the F and systemic exposure (i.e., AUC and Cmax) of TEV in the SESS-TD crystal and TDF groups were increased compared to those in the TEV group. The pharmacokinetic profiles of TEV between the SESS-TD and TDF groups were comparable. Moreover, the pharmacokinetic profiles of TEV remained unchanged even after the administration of the SESS-TD crystal and TDF stored for 12 months. Based on the improved F after the SESS-TD crystal administration and the stable condition of the SESS-TD crystal after 12 months, SESS-TD crystal may have enough pharmacokinetic feasibility to replace TDF.
An Experimental Study of Multiphoton Ionization in Fused Silica at IR and Visible Wavelengths
Authors: Bogatskaya Anna , Gulina Yulia , Smirnov Nikita , Gritsenko Ilia , Kudryashov Sergey , Popov Alexander
Published: May 2023

We present the results of an experimental study of multiphoton ionization in fused silica, using a linearly polarized femtosecond Satsuma fiber laser with an active medium based on Yb+3 ions, at 515 -nm and 1030 -nm wavelengths. The radiation transmission in the fused silica was measured as a function of the laser intensity and wavelength and the data were analyzed using a theoretical model based on the Keldysh theory. We determined the multiphoton absorption cross-sections in the fused silica in the case of four- and eight-photon ionization and analyzed the contribution of avalanche ionization. The obtained results provide insight into the fundamental processes involved in multiphoton ionization and have implications for its applications, such as laser micromachining and material processing.
Numerical Method for the Design of Compact Adiabatic Devices with Multiple Parameter Variations
Authors: Liang Tu-Lu , Cheng Xi , Yu Mei , Zhang Lingyan , Shi Jin , Wu Gangxiong , Rong Weiwei , Shao Wei
Published: May 2023

In this study, a numerical method for designing efficient adiabatic devices with multiple structural parameter variations (NAMSP) is developed. This method can be applied to a wide range of devices based on adiabatic mode evolution structures. The numerical design complexity of multiple structural parameter variations will be greatly improved compared to the case of a single parameter variation. Therefore, an efficient domain decomposition scheme was originally introduced into the NAMSP method. The proposed method can help compute compact adiabatic guided-wave shapes for these adiabatic devices with multiple structural parameter variations. Adiabatic devices with multiple structural parameter variations are used to connect different complex waveguides, which are often difficult to design using analytical methods. The design involves tapering the width of the two or more core layers at one time; however, this change in the width typically affects the mode both vertically and horizontally. Our numerical method allows the shape of the width variation for each layer that facilitates compact adiabatic mode transformation to be obtained. The efficiency of the adiabatic device that was designed using the NAMSP method considerably exceeds that obtained using a linear-shaped device. Moreover, our designed adiabatic device enables an ultra-wide operating bandwidth (spans in the wavelength from 1050 nm to 4780 nm).
Application of Crossed Polarizer Method in the Measurement of Differential Group Delay of Optical Fibers
Authors: Wu Cheng , Yu Fei , Feng Suya , Yu Chunlei , Xu Lixin , Zhai Ruizhan , Jia Zhongqing , Hu Lili
Published: May 2023

In this paper, we report the use of crossed polarizer technique to measure the differential group delay (DGD) of few-mode optical fiber (FMF). The windowed Fourier transform (WFT) is applied in the analysis of beat length measurement in the spectral domain to obtain the dependence of DGD as a function of wavelength. The birefringence of polarization-maintaining fiber (PMF) and the DGD of FMF are measured by applying our method. We discuss the noise background, the width of DGD peaks, and the possible errors introduced in the optical path in the modified crossed polarizer technique.
Synergistic Action of Biosynthesized Silver Nanoparticles and Culture Supernatant of Bacillus amyloliquefacience against the Soft Rot Pathogen Dickeya dadantii
Authors: Hossain Afsana , Luo Jinyan , Ali Md. Arshad , Chai Rongyao , Shahid Muhammad , Ahmed Temoor , M. Hassan Mohamed , H. Kadi Roqayah , An Qianli , Li Bin , Wang Yanli
Published: May 2023

Nanomaterials are increasingly being used for crop growth, especially as a new paradigm for plant disease management. Among the other nanomaterials, silver nanoparticles (AgNPs) draw a great deal of attention because of their unique features and multiple usages. Rapid expansion in nanotechnology and utilization of AgNPs in a large range of areas resulted in the substantial release of these nanoparticles into the soil and water environment, causing concern for the safety of ecosystems and phytosanitary. In an attempt to find an effective control measure for sweet potato soft rot disease, the pathogen Dickeya dadantii was exposed to AgNPs, the cell-free culture supernatant (CFCS) of Bacillus amyloliquefaciens alone, and both in combination. AgNPs were synthesized using CFCS of Bacillus amyloliquefaciens strain A3. The green synthesized AgNPs exhibited a characteristic surface plasmon resonance peak at 410–420 nm. Electron microscopy and X-ray diffraction spectroscopy determined the nanocrystalline nature and 20–100 nm diameters of AgNPs. Release of metal Ag+ ion from biosynthesized AgNPs increases with time. AgNPs and CFCS of B. amyloliquefaciens alone exhibited antibacterial activity against the growth, biofilm formation, swimming motility, and virulence of strain A3. The antibacterial activities elevated with the elevation in AgNPs and CFCS concentration. Similar antibacterial activities against D. dadantii were obtained with AgNPs at 50 µg·mL−1, 50% CFCS alone, and the combination of AgNPs at 12 µg·mL−1 and 12% CFCS of B. amyloliquefaciens. In planta experiments indicated that all the treatments reduced D. dadantii infection and increased plant growth. These findings suggest that AgNPs along with CFCS of B. amyloliquefaciens can be applied to minimize this bacterial disease by controlling pathogen-contaminated sweet potato tuber with minimum Ag nano-pollutant in the environment.
Invasive Plant Species Driving the Biotic Homogenization of Plant-Frugivore Interactions in the Atlantic Forest Biodiversity Hotspot
Authors: Dáttilo Wesley , Luna Pedro , Villegas-Patraca Rafael
Published: May 2023

Although biological invasions are a common and intensively studied phenomenon, most studies often ignore the biotic interactions that invasive species play in the environment. Here, we evaluated how and why invasive plant species are interconnected within the overall frugivory network of the Brazilian Atlantic Forest, an important global biodiversity hotspot. To do this, we used the recently published Atlantic Frugivory Dataset to build a meta-network (i.e., a general network made of several local networks) that included interactions between 703 native and invasive plant species and 331 frugivore species. Using tools derived from complex network theory and a bootstrap simulation approach, we found that the general structure of the Atlantic Forest frugivory network (i.e., nestedness and modularity) is robust against the entry of invasive plant species. However, we observed that invasive plant species are highly integrated within the frugivory networks, since both native and invasive plant species play similar structural roles (i.e., plant status is not strong enough to explain the interactive roles of plant species). Moreover, we found that plants with smaller fruits and with greater lipid content play a greater interactive role, regardless of their native or invasive status. Our findings highlight the biotic homogenization involving plant–frugivore interactions in the Atlantic Forest and that the impacts and consequences of invasive plant species on native fauna can be anticipated based on the characteristics of their fruits.
Artificial Intelligence: A Promising Tool in Exploring the Phytomicrobiome in Managing Disease and Promoting Plant Health
Authors: Zhao Liang , Walkowiak Sean , Fernando Wannakuwattewaduge Gerard Dilantha
Published: May 2023

There is increasing interest in harnessing the microbiome to improve cropping systems. With the availability of high—throughput and low—cost sequencing technologies, gathering microbiome data is becoming more routine. However, the analysis of microbiome data is challenged by the size and complexity of the data, and the incomplete nature of many microbiome databases. Further, to bring microbiome data value, it often needs to be analyzed in conjunction with other complex data that impact on crop health and disease management, such as plant genotype and environmental factors. Artificial intelligence (AI), boosted through deep learning (DL), has achieved significant breakthroughs and is a powerful tool for managing large complex datasets such as the interplay between the microbiome, crop plants, and their environment. In this review, we aim to provide readers with a brief introduction to AI techniques, and we introduce how AI has been applied to areas of microbiome sequencing taxonomy, the functional annotation for microbiome sequences, associating the microbiome community with host traits, designing synthetic communities, genomic selection, field phenotyping, and disease forecasting. At the end of this review, we proposed further efforts that are required to fully exploit the power of AI in studying phytomicrobiomes.
Advances in Biotechnological Production and Metabolic Regulation of Astragalus membranaceus
Authors: Ji Baoyu , Xuan Liangshuang , Zhang Yunxiang , Zhang Guoqi , Meng Jie , Mu Wenrong , Liu Jingjing , Paek Kee-Yoeup , Park So-Young , Wang Juan , Gao Wenyuan
Published: May 2023

Legume medicinal plants Astragalus membranaceus are widely used in the world and have very important economic value, ecological value, medicinal value, and ornamental value. The bioengineering technology of medicinal plants is used in the protection of endangered species, the rapid propagation of important resources, detoxification, and the improvement of degraded germplasm. Using bioengineering technology can effectively increase the content of secondary metabolites in A. membranaceus and improve the probability of solving the problem of medicinal plant resource shortage. In this review, we focused on biotechnological research into A. membranaceus, such as the latest advances in tissue culture, including callus, adventitious roots, hairy roots, suspension cells, etc., the metabolic regulation of chemical compounds in A. membranaceus, and the research progress on the synthetic biology of astragalosides, including the biosynthesis pathway of astragalosides, microbial transformation of astragalosides, and metabolic engineering of astragalosides. The review also looks forward to the new development trend of medicinal plant biotechnology, hoping to provide a broader development prospect for the in-depth study of medicinal plants.
Sensitivity of the Photosynthetic Apparatus in Maize and Sorghum under Different Drought Levels
Authors: Stefanov Martin , Rashkov Georgi , Borisova Preslava , Apostolova Emilia
Published: May 2023

Drought is one of the main environmental stress factors affecting plant growth and yield. The impact of different PEG concentrations on the photosynthetic performance of maize (Zea mays L. Mayflower) and sorghum (Sorghum bicolor L. Foehn) was investigated. The activity of the photosynthetic apparatus was assessed using chlorophyll fluorescence (PAM and JIP test) and photooxidation of P700. The data revealed that water deficiency decreased the photochemical quenching (qP), the ratio of photochemical to nonphotochemical processes (Fv/Fo), the effective quantum yield of the photochemical energy conversion in PSII (ΦPSII), the rate of the electron transport (ETR), and the performance indexes PItotal and PIABS, as the impact was stronger in sorghum than in maize and depended on drought level. The PSI photochemistry (P700 photooxidation) in sorghum was inhibited after the application of all studied drought levels, while in maize, it was registered only after treatment with higher PEG concentrations (30% and 40%). Enhanced regulated energy losses (ΦNPQ) and activation of the state transition under drought were also observed in maize, while in sorghum, an increase mainly in nonregulated energy losses (ΦNO). A decrease in pigment content and relative water content and an increase in membrane damage were also registered after PEG treatment. The experimental results showed better drought tolerance of maize than sorghum. This study provides new information about the role of regulated energy losses and state transition for the protection of the photosynthetic apparatus under drought and might be a practical approach to the determination of the drought tolerance of plants.
FF-Net: Feature-Fusion-Based Network for Semantic Segmentation of 3D Plant Point Cloud
Authors: Guo Xindong , Sun Yu , Yang Hua
Published: May 2023

Semantic segmentation of 3D point clouds has played an important role in the field of plant phenotyping in recent years. However, existing methods need to down-sample the point cloud to a relatively small size when processing large-scale plant point clouds, which contain more than hundreds of thousands of points, which fails to take full advantage of the high-resolution of advanced scanning devices. To address this issue, we propose a feature-fusion-based method called FF-Net, which consists of two branches, namely the voxel-branch and the point-branch. In particular, the voxel-branch partitions a point cloud into voxels and then employs sparse 3D convolution to learn the context features, and the point-branch learns the point features within a voxel to preserve the detailed point information. Finally, an attention-based module was designed to fuse the two branch features to produce the final segmentation. We conducted extensive experiments on two large plant point clouds (maize and tomato), and the results showed that our method outperformed three commonly used models on both datasets and achieved the best mIoU of 80.95% on the maize dataset and 86.65% on the tomato dataset. Extensive cross-validation experiments were performed to evaluate the generalization ability of the models, and our method achieved promising segmentation results. In addition, the drawbacks of the proposed method were analyzed, and the directions for future works are given.
Synthesis of Selenium Nanoparticles Modified by Quaternary Chitosan Covalently Bonded with Gallic Acid
Authors: Lunkov Alexey , Konovalova Mariya , Shagdarova Balzhima , Zhuikova Yuliya , Il’ina Alla , Varlamov Valery
Published: May 2023

Quaternary chitosan derivative with covalently bonded antioxidant (QCG) was used as media for synthesis of selenium nanoparticles (SeNPs). SeNPs were characterized using AFM, TEM, and DLS methods. The data confirmed the formation of stable nanoparticles with a positive charge (34.86–46.73 mV) and a size in the range 119.5–238.6 nm. The antibacterial and fungicidal activity of SeNPs occurred within the range of values for chitosan derivatives. In all cases, the highest activity was against C. albicans (MIC 125 µg/mL). The toxicity of the modified selenium nanoparticles to eukaryotic cells was significantly higher. Among nanoparticle samples, SeNPs that were synthesized at 55 °C demonstrated the highest toxicity against Colo357 and HaCaT cell lines. Based on these results, SeNPs loaded with doxorubicin were obtained. DOX loading efficiency was about 18%. QCG-SeNPs loaded with DOX at a concentration of 1.25 μg/mL inhibited more than 50% of hepatocarcinoma (Colo 357) cells and about 70% of keratinocytes (HaCaT).
Experimentation and Numerical Modeling of Peak Temperature in the Weld Joint during Rotary Friction Welding of Dissimilar Plastic Rods
Authors: Kuo Chil-Chyuan , Gurumurthy Naruboyana , Chen Hong-Wei , Hunag Song-Hua
Published: May 2023

Rotary friction welding (RFW) could result in lower welding temperature, energy consumption, or environmental effects as compared with fusion welding processes. RFW is a green manufacturing technology with little environmental pollution in the field of joining methods. Thus, RFW is widely employed to manufacture green products. In general, the welding quality of welded parts, such as tensile strength, bending strength, and surface hardness is affected by the peak temperature in the weld joint during the RFW of dissimilar plastic rods. However, hitherto little is known about the domain knowledge of RFW of acrylonitrile butadiene styrene (ABS) and polycarbonate (PC) polymer rods. To prevent random efforts and energy consumption, a green method to predict the peak temperature in the weld joint of dissimilar RFW of ABS and PC rods was proposed. The main objective of this work is to investigate the peak temperature in the weld joint during the RFW using COMSOL multiphysics software for establishing an empirical technical database of RFW of dissimilar polymer rods under different rotational speeds. The main findings include that the peak temperature affecting the mechanical properties of RFW of PC and ABS can be determined by the simulation model proposed in this work. The average error of predicting the peak temperature using COMSOL software for five different rotational speeds is about 15 °C. The mesh element count of 875,688 is the optimal number of meshes for predicting peak temperature in the weld joint. The bending strength of the welded part (y) using peak welding temperature (x) can be predicted by the equation of y = −0.019 x2 + 5.081x − 200.75 with a correlation coefficient of 0.8857. The average shore A surface hardness, impact energy, and bending strength of the welded parts were found to be increased with increasing the rotational speed of RFW.
A Novel Approach for Design and Manufacturing of Curvature-Featuring Scaffolds for Osteochondral Repair
Authors: Marcelino Pedro , Silva João Carlos , Moura Carla S. , Meneses João , Cordeiro Rachel , Alves Nuno , Pascoal-Faria Paula , Ferreira Frederico Castelo
Published: May 2023

Osteochondral (OC) defects affect both articular cartilage and the underlying subchondral bone. Due to limitations in the cartilage tissue’s self-healing capabilities, OC defects exhibit a degenerative progression to which current therapies have not yet found a suitable long-term solution. Tissue engineering (TE) strategies aim to fabricate tissue substitutes that recreate natural tissue features to offer better alternatives to the existing inefficient treatments. Scaffold design is a key element in providing appropriate structures for tissue growth and maturation. This study presents a novel method for designing scaffolds with a mathematically defined curvature, based on the geometry of a sphere, to obtain TE constructs mimicking native OC tissue shape. The lower the designed radius, the more curved the scaffold obtained. The printability of the scaffolds using fused filament fabrication (FFF) was evaluated. For the case-study scaffold size (20.1 mm × 20.1 mm projected dimensions), a limit sphere radius of 17.064 mm was determined to ensure printability feasibility, as confirmed by scanning electron microscopy (SEM) and micro-computed tomography (μ-CT) analysis. The FFF method proved suitable to reproduce the curved designs, showing good shape fidelity and replicating the expected variation in porosity. Additionally, the mechanical behavior was evaluated experimentally and by numerical modelling. Experimentally, curved scaffolds showed strength comparable to conventional orthogonal scaffolds, and finite element analysis was used to identify the scaffold regions more susceptible to higher loads.
Effect of the Acid Medium on the Synthesis of Polybenzimidazoles Using Eaton’s Reagent
Authors: García-Vargas Miriam , Rojas-Rodríguez Mario , Palacios-Alquisira Joaquín , Fomina Lioudmila , Aguilar-Lugo Carla , Alexandrova Larissa
Published: May 2023

The influence of trifluoromethanesulfonic (TFSA) superacid on conditions of the synthesis of polybenzimidazoles, such as OPBI and CF3PBI, was studied. It was shown that the polycondensations proceeded smoother and at lower temperatures in the presence of the TFSA in Eaton’s Reagent and that polymers of high molecular weights, and readily soluble in organic solvents, were obtained. The effect was more pronounced for CF3PBI, where the low reactivity monomer, 4,4′ (hexafluoroisoproylidene)bis (benzoic acid), was used. CF3PBI was obtained at a moderate temperature of 140 °C with no gel fraction and exhibited an inherent viscosity twice higher than the one obtained by the traditional method. In fact, the addition of TFSA allows the obtention of soluble N-phenyl substituted CF3PBI by direct synthesis, which had not been obtained otherwise. Thus, the use of TFSA is a good media for the synthesis of N-substituted PBIs under relatively mild conditions.
Tailoring Photoprotection of Polylactide with New Isobornyl Derivatives of Phenol and Aniline
Authors: Belyi Vladimir A. , Kuzivanov Ivan M. , Fedorova Irina V. , Shumova Olga A. , Tropnikov Evgeniy M. , Istomina Elena I. , Chukicheva Irina Yu. , Kuchin Aleksandr V.
Published: May 2023

This article is devoted to the development of new photostabilizers for polylactide (PLA), a polymer that is an environmentally friendly alternative to polymers and is based on fossil raw materials. We have elucidated the role of the reaction center of two potential PLA photoprotectors: N-isobornylaniline and 2-isobornylphenol, in reactions occurring in a polymer matrix under the action of UV-C radiation. PLA samples with the photostabilizers were irradiated under a wavelength of 253.7 nm for 4, 8 and 12 h. The effectiveness of the photostabilizers was evaluated based on FTIR spectrometric data, 1H and 13C NMR, scanning electron microscopy and simultaneous thermal analysis (TG-DSC). Both stabilizers led to the protection of ester bonds between monomer units of PLA. However, 2-isobornylphenol proved to be more effective at a concentration of 0.05 wt.%, while the optimal concentration of N-isobornylaniline was 0.5 wt.% by weight. TG-DSC showed that the addition of N-isobornylaniline led to an increase in PLA resistance to thermal decomposition; the temperature of the onset of weight loss increased by 2.8 °C at 0.05 wt.% and by 8.1 °C at 0.5 wt.% of N-isobornylaniline. The photoprotector 2-isobornylphenol, on the contrary, reduced the thermal stability of PLA.
Hysteresis Behavior Modeling of Magnetorheological Elastomers under Impact Loading Using a Multilayer Exponential-Based Preisach Model Enhanced with Particle Swarm Optimization
Authors: Mohd. Alawi Alawiyah Hasanah , Hudha Khisbullah , Kadir Zulkiffli Abd. , Amer Noor Hafizah
Published: May 2023

Magnetorheological elastomers (MREs) are a type of smart material that can change their mechanical properties in response to external magnetic fields. These unique properties make them ideal for various applications, including vibration control, noise reduction, and shock absorption. This paper presents an approach for modeling the impact behavior of MREs. The proposed model uses a combination of exponential functions arranged in a multi-layer Preisach model to capture the nonlinear behavior of MREs under impact loads. The model is trained using particle swarm optimization (PSO) and validated using experimental data from drop impact tests conducted on MRE samples under various magnetic field strengths. The results demonstrate that the proposed model can accurately predict the impact behavior of MREs, making it a useful tool for designing MRE-based devices that require precise control of their impact response. The model’s response closely matches the experimental data with a maximum prediction error of 10% or less. Furthermore, the interpolated model’s response is in agreement with the experimental data with a maximum percentage error of less than 8.5%.
Effect of Basalt Fiber Content and Length on the Strength and Crack Development of Polyvinyl Alcohol/Basalt Hybrid Fiber-Reinforced Cement Soil
Authors: Shu Yonghua , Zhang Jingshuang
Published: May 2023

Polyvinyl alcohol (PVA) fiber is widely used in geotechnical engineering because of its excellent physical and mechanical properties; however, PVA fibers are prone to aging, while basalt fiber has a natural anti-aging ability, which can be added to cement material to effectively eliminate the effects of aging on PVA fiber. Previous experiments identified that the optimum content of PVA fiber is 0.5% (mass fraction, the same below). Based on this, we continued to add basalt fibers of different lengths (3 mm, 6 mm, 9 mm, 12 mm, 18 mm, 30 mm) and different contents (0%, 0.25%, 0.5%, 0.75%, 1%) to study the effect of both length and content of basalt fibers on the strength of cement soil specimens. It was concluded that adding 0.5 % of 9 mm basalt fiber results in the greatest increase in unconfined compressive strength (UCS). The UCS reached 12.59 MPa, which was 71% higher than specimens without fiber, and a regression analysis was carried out to obtain the relationship among them. The ratio of cement soil in the highest UCS and the relationship among the UCS, the length, and the content of basalt fiber can be used as a reference for practical projects. In addition, digital image correlation (DIC) technology was used to analyze the surface cracks and horizontal strain field when the peak strain was reached at each content and length of the basalt fiber. Finally, the curing mechanism for hybrid fiber cement soil was analyzed by combining the results of the UCS test, DIC test, and SEM test.
Part B: Improvement of the Optical Properties of Cellulose Nanocrystals Reinforced Thermoplastic Starch Bio-Composite Films by Ex Situ Incorporation of Green Silver Nanoparticles from Chaetomorpha linum
Authors: M’sakni Nour Houda , Alsufyani Taghreed
Published: May 2023

The study was used in the context of realigning novel low-cost materials for their better and improved optical properties. Emphasis was placed on the bio-nanocomposite approach for producing cellulose/starch/silver nanoparticle films. These polymeric films were produced using the solution casting technique followed by the thermal evaporation process. The structural model of the bio-composite films (CS:CL-CNC7:3–50%) was developed from our previous study. Subsequently, in order to improve the optical properties of bio-composite films, bio-nanocomposites were prepared by incorporating silver nanoparticles (AgNPs) ex situ at various concentrations (5–50% w/w). Characterization was conducted using UV-Visible (UV-Vis), Fourier Transform Infrared (FTIR), Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) to understand the structure–property relationships. The FTIR analysis indicated a reduction in the number of waves associated with the OH functional groups by adding AgNPs due to the formation of new hydrogen bonds between the bio-composite matrix and the CL-WE-AgNPs. Based on mathematical equations, the optical bandgap energy, the energy of Urbach, the edge of absorption (Ed), and the carbon clusters (N) were estimated for CS:CL-CNC and CS:CL-CNC-AgNPs (5–50%) nanocomposite films. Furthermore, the optical bandgap values were shifted to the lower photon energy from 3.12 to 2.58 eV by increasing the AgNPs content, which indicates the semi-conductor effect on the composite system. The decrease in Urbach’s energy is the result of a decrease in the disorder of the biopolymer matrix and/or attributed to an increase in crystalline size. In addition, the cluster carbon number increased from 121.56 to 177.75, respectively, from bio-composite to bio-nanocomposite with 50% AgNPs. This is due to the presence of a strong H-binding interaction between the bio-composite matrix and the AgNPs molecules. The results revealed that the incorporation of 20% AgNPs into the CS:CL-CNC7:3–50% bio-composite film could be the best candidate composition for all optical properties. It can be used for potential applications in the area of food packaging as well as successfully on opto-electronic devices.
Structures, Properties, and Bioengineering Applications of Alginates and Hyaluronic Acid
Authors: Zhang Shuping , Dong Jiayu , Pan Renxue , Xu Zhenyang , Li Mengyuan , Zang Rui
Published: May 2023

In recent years, polymeric materials have been used in a wide range of applications in a variety of fields. In particular, in the field of bioengineering, the use of natural biomaterials offers a possible new avenue for the development of products with better biocompatibility, biodegradability, and non-toxicity. This paper reviews the structural and physicochemical properties of alginate and hyaluronic acid, as well as the applications of the modified cross-linked derivatives in tissue engineering and drug delivery. This paper summarizes the application of alginate and hyaluronic acid in bone tissue engineering, wound dressings, and drug carriers. We provide some ideas on how to replace or combine alginate-based composites with hyaluronic-acid-based composites in tissue engineering and drug delivery to achieve better eco-economic value.
Effect of Mortise and Tenon Structure on the Properties of Wood Flour Polyvinyl Chloride-Laminated Veneer Lumber Co-Extruded Composites
Authors: Zong Guanggong , Zhou Jinjiang , Zhang Mengyan , Ma Yanqiu , Zhao Yang , He Xiaoyan , Hao Jianxiu , Wang Fangfang
Published: May 2023

Core–shell composites with strong weather resistance, mechanical strength and creep resistance can be prepared using co-extrusion technology. Considering the weak bonding strength between core–shell interfaces, this study started from the concept of a mortise and tenon combination; three types of conical, rectangular and trapezoidal mortise and tenon joints were prepared, and their bending properties, long-term creep properties, interfacial bonding properties, and dimensional stability properties were tested. Results showed that the mortise and tenon structure could form a mechanical interlock between the outer-shell-layer polyvinyl chloride (PVC) wood–plastic composite (WPVC) and the inner-core-layer laminated veneer lumber (LVL), which could effectively improve the interface bonding property between the two layers. Among them, the trapezoidal mortise and tenon structure had the largest interface bonding force compared with the tapered and rectangular mortise and tenon structure, where the interface bonding strength reached 1.01 MPa. Excellent interface bonding can effectively transfer and disperse stress, so the trapezoidal mortise and tenon structure had the best bending properties and creep resistance, with a bending strength of 59.54 MPa and a bending modulus of 5.56 GPa. In the long-term creep test, the deformation was also the smallest at about 0.2%, and its bending properties, creep resistance and interface bonding performance were also the best. The bending strength was 59.54 MPa and the bending modulus was 5.56 GPa; in the long-term creep test, the strain curve was the lowest, about 0.2%. In addition, the mortise and tenon structure could disperse the stress of the inner shell LVL after water absorption and expansion, thus significantly improving the dimensional stability of the co-extruded composite after water absorption.
Alkaline Treatment Investigation for Sedge Fibers (Cyperus malaccensis): A Promising Enhancement
Authors: Neuba Lucas de Mendonça , Junio Raí Felipe Pereira , Souza Andressa Teixeira , Chaves Yago Soares , Tavares Sheron , Palmeira Alexandre Alvarenga , Monteiro Sergio Neves , Pereira Artur Camposo
Published: May 2023

Natural fibers have some advantages in comparison to synthetic fibers, especially because they are more environmentally friendly. For this reason, using them as a reinforcement for polymeric matrices is growing exponentially. However, they present the disadvantage of having the hydrophilic nature, which strongly reduces the interface interaction. Sedge fibers have been investigated when reinforcing an epoxy matrix in terms of ballistic properties and mechanical performance. Aiming to enhance the fiber−matrix interface, an alkali treatment was proposed. The group conditions were divided into three NaOH concentrations (3%, 5%, and 10%), as well as the three periods of immersion (24, 48, and 72 h). Therefore, nine different conditions were investigated in terms of their thermal behaviors, chemical structures, physical structures, and morphological aspects. Based on TGA curves, it could be noticed that treatments related to 3% NaOH for 24 h and 48 h exhibited better thermal stability properties. For the time of 48 h, better thermal stability with for a decay of the thermal DSC curve was shown for all treatment conditions. The FTIR spectra has shown a reduction of waxes for higher NaOH concentrations. The XRD diffractogram exhibited an increase in the crystallinity index only for 5% NaOH and an immersion time of 48 h. The morphological aspects of fibers treated with 5% and 10% of NaOH have shown that the treatments have damaged the fiber, which highlighted the crystallinity index reductions.
Water Influence on the Physico-Chemical Properties and 3D Printability of Choline Acrylate—Bacterial Cellulose Inks
Authors: Fedotova Veronika S. , Sokolova Maria P. , Vorobiov Vitaly K. , Sivtsov Eugene V. , Lukasheva Natalia V. , Smirnov Michael A.
Published: May 2023

The aim of this work was to study the influence of water as a co-solvent on the interaction between a polymerizable ionic liquid—choline acrylate (ChA)—and bacterial cellulose. Bacterial cellulose dispersed in ChA is a new type of UV-curable biopolymer-based ink that is a prospective material for the 3D printing of green composite ion-gels. Higher cellulose content in inks is beneficial for the ecological and mechanical properties of materials, and leads to increased viscosity and the yield stress of such systems and hampers printability. It was found that the addition of water results in (1) a decrease in the solvent viscosity and yield stress; and (2) a decrease in the stability of dispersion toward phase separation under stress. In this work, an optimal composition in the range of 30–40 wt% water content demonstrating 97–160 Pa of yield stress was found that ensures the printability and stability of inks. The rheological properties of inks and mechanical characteristics (0.7–0.8 MPa strength and 1.1–1.2 MPa Young’s modulus) were obtained. The mechanism of influence of the ratio ChA/water on the properties of ink was revealed with atomic force microscopy, wide-angle X-ray diffraction studies of bacterial cellulose after regeneration from solvent, and computer simulation of ChA/water mixtures and their interaction with the cellulose surface.
Assessment of Silicone Rubber/Lead Oxide Composites Enriched with Bi2O3, WO3, BaO, and SnO2 Nanoparticles for Radiation Shielding Applications
Authors: Alresheedi Mohammed Thamer , Elsafi Mohamed , Aladadi Yosef T. , Abas Ahmad Fauzi , Ganam Abdullrahman Bin , Sayyed M. I. , Mahdi Mohd Adzir
Published: May 2023

This study aimed to prepare silicone rubber composites with heavy metal oxide nanoparticles for gamma ray shielding applications. Different heavy metal oxide nanoparticles were incorporated into the silicone rubber matrix, and the prepared composites were characterized for their thermal, mechanical, and radiation shielding properties. The density of the prepared SR samples ranged from 1.25 to 2.611 g·cm−3, with SR-2 having the highest density due to the presence of lead oxide. Additionally, the thermal stability of the materials improved with the addition of HMO nanoparticles, as indicated by TGA results. The prepared SR materials showed ultimate deformation displacement ranging from 14.17 to 21.23 mm, with the highest value recorded for SR-3 and the lowest for SR-2. We investigated the transmission factor (TF) of gamma rays through silicone rubber (SR) composites with different heavy metal oxide (HMO) nanoparticles. The addition of HMOs resulted in a decrease in TF values, indicating improved radiation shielding performance. The TF was found to be lowest in SR-5, which contained 15% of Bi2O3, WO3, BaO, and Zr2O3 each. The linear attenuation coefficient (LAC) of the SR samples was also evaluated, and it was found that the incorporation of HMOs increased the probability of photon interactions, leading to improved radiation protection effectiveness. The half-value layer (HVL) of the SR samples was also examined, and it was found that the addition of HMOs resulted in a significant reduction in HVL values, particularly at low energy levels. SR-5 had the lowest HVL among the group, while SR-2, SR-3, and SR-4 had higher HVL values. These results demonstrate the effectiveness of using HMOs in enhancing the radiation shielding properties of SR composites, particularly for low-energy gamma rays.