bluuebunny/crossref_metadata_2025 huggingface dataset:
Inventory Optimization for Manufacturing Industries
Authors: Yashh Hemant Gaikwad , Shafighi Najla
Published: July 2023

Inventory management being the significant part of the supply chain drives the maximum monetary value. The purpose of this study is to optimize an inventory for Vhrushi India Pvt. Ltd. by reducing the inventory cost and developing an inventory management system. The Quantitative approach is used for the research work. The inventory cost reduction is performed by application of EOQ modeland excel visual basics is used for Inventory Management system. The author intends to determine the appropriate order quantity and reorder point by implementation of EOQ (Economic Order Quantity) model. As technology advances, businesses must manage their inventories quickly, precisely, and accurately to support their operations. Therefore, the development of inventory management system is the second part of the research which smoothens the material flow and rings transparency in it by tracking the material movement and reducing the human errors. The result of the investigation provides economic order quantities, reorder points for all the items and IMS developed. Furthermore, the regression analysis enhances the value of the findings which shows two independent variables which are unit price and holding cost are significantly correlated with the Inventory cost. In this case, Holding Cost is considered as the most important factor in terms of affecting the Inventory Cost.
Analysis of Current Infrastructure & Future Perspective For E-Mobility in India
Authors: Lingayat Shubham , Shafighi Najla
Published: July 2023

The study will highlight several infrastructural problems and some crucial variables that may push India’s transportation industry to buy an electric automobile. The study’s primary section will shed light on the environmental, economic, and other benefits of e-mobility transportation. Afterwards, the second part reflects the basic understanding of e-mobility and the everyday challenges and barriers to e-mobility. The next part of the study covers research aspects such as the research strategy and different methods and tools for data collection to complete the research work. The next chapter demonstrates the analysis of the data gathered from the different sources. Following this, the article indicates the approach strategy of the Indian government toward e-mobility and infrastructural comparison between India and some developed countries to figure out the main factors. In the end, the last chapter of this article recommends some strategies and solutions to counter challenges that can affect the Indian automobile sector and the determination of some significant elements to ensure an effortless change from conventional mobility to an electric method of transportation.
Rapport homme/femme dans la chanson congolaise moderne 1960-2000)
Authors: KALOLA Kipangu Zuy
Published: July 2023

Cette étude s’est intéressée à la chanson congolaise moderne de la période de 1960 à 2000. Elle nous intéresse parce que la chanson constitue « un immense champ d'investigation des signes qui échappent aux observateurs de la vie des signes au sein de la vie sociale. En outre, nous estimons que le texte de cette chanson peut servir de support dans une classe de texte ou d'un débat thématique sur diverses questions de la culture congolaise. Nous y avons particulièrement abordé la problématique des rapports « Homme/Femme ». Pour mener notre étude, nous avons collecté une centaine de chansons parmi les plus marquantes et en vogue de la période sous-examen (1960-2000). Nous les avons auditionnés, transcrit en lingala (langue de prédilection de chanson congolaise) et traduit en français. Nous avons ensuite recouru à quelques analyses afin de nous rendre compte si les rapports « H/F » sont effectivement actualisés dans la chanson congolaise moderne. Ceux-ci sont, non seulement d'actualité dans toutes les sociétés de nos jours, mais aussi parce qu'ils sont un phénomène culturel. En effet, la « Une » des médias ne cesse d'évoquer les cas de femmes violées et violentées par les hommes, et à travers les âges ainsi que différentes cultures, il s'est toujours posé le problème des rapports homme-femme ». Il nous revient que cette question est aussi manifestée dans la chanson congolaise moderne, dans la mesure où il existe, dans la société congolaise, un problème des « Rapport (s) H./F qui se pose en des termes de l'incapacité totale de la femme, l'infériorisant souvent et la minorisant. Comme il est attesté que la chanson véhicule la culture d'un peuple, en l'introduisant à l'école et en l'enseignant, on enseignerait, de ce fait, la culture. Mots-clés : Chanson, rapport (s) H/F, gender, émancipation, culture.
Application des mesures d’asepsie lors du cathétérisme veineux dans les hôpitaux de BUTEMBO
Authors:   ISTM Butembo, KAKULE KATUNGU , LULENDI KASEREKA
Published: July 2023

L’environnement est chargé de micro-organisme. Certes, ils ne sont pas tous nuisibles, mais si ces micro- organismes sont pathogènes et virulents, ils envahissent l’organisme et provoquent une infection. L’objectif général poursuivi dans cette étude est d’apprécier le respect de l’asepsie lors du cathétérisme veineux périphérique. Nos enquêtes se sont réalisées dans 4 grandes structures de santé de la Ville de Butembo dans la province de Nord-Kivu. Pour réaliser cette étude, nous avons procédé à un échantillonnage occasionnel de 69 séances de cathétérisme veineux périphérique réalisés par les infirmiers dont 20 à l’HGR Katwa, 16 à l’HGR Kitatumba, 16 à l’Hôpital de Matanda et 17 aux Cliniques UCG au cours de la période allant du 10 janvier au 10 mars 2018. Sur 69 séances de pose de cathéter veineux périphérique, le lavage des mains par les infirmiers n’a été observé à 94.2% des cas lors du cathétérisme veineux périphérique, 97.1% d’infirmiers n’ont pas enfilé les gants avant la pose de cathéter veineux, 88.4% des infirmiers des Hôpitaux de Butembo ont manipulé correctement le cathéter veineux en respectant l’asepsie. Sur 69 cathéters veineux périphériques placés, 45 ont été retirés après 3 jours, soit 65.2%, 75.3% des infirmiers ont bien désinfecté le site d’insertion du cathéter lors de 52 séances. Il y a donc des améliorations à effectuer en vue de respecter scrupuleusement les règles d’asepsie. Mots-clés : Asepsie, Cathéter veineux, infirmiers
The Urgency of Citizenship Education in the 2013 Curriculum in Class V MI/SD
Authors: Farich Alfani Moch.
Published: July 2023

The problems that occur in education in Indonesia include the decrease in the degradation of the character of elementary school students, the use of learning methods that seem difficult for students to understand, are less flexible, less democratic, and tend to be more dominant using one method. For this reason, MI/SD Citizenship Education learning must be strengthened so that in the future it can combine the practice of Pancasila values in everyday life, westernized culture that has permeated Indonesian culture can be minimized starting from styles in speaking, dressing or others. In this study the aims were to describe the urgency of civics education in elementary schools, civics education in the Indonesian context, and the conceptual framework of civic competence in the 2013 curriculum. This study adopted an idea of a descriptive qualitative. the use of techniques applied in this research by taking interview techniques, documentation, and field notes through several stages including data collection, recording, reviewing data sources, and processing information. This research was conducted at MIN 6 Brebes by taking the subjects in this study were fifth grade students and teaching staff who were at MIN 6 Brebes. The urgency of elementary school citizenship education is to prepare young people who understand the contemporary world, play an active role both in solving national and global problems, and to become active contributors to a more just, peaceful, tolerant, safe and sustainable world.
PENGGUNAAN KOMBINASI OBAT ANALGETIKA PADA PASIEN PASCA OPERASI DI RUMAH SAKIT X JAKARTA
Authors: Abdillah Eric Kurnia , Ismail Abdul Rahman Reza , Nugrahini Lestari , Islamiyah Nur , Tasmin Taufani
Published: July 2023

Analgesik adalah obat yang selektif mengurangi rasa sakit dengan bertindak dalam sistem saraf pusat atau pada mekanisme nyeri perifer, tanpa secara signifikan mengubah kesadaran. Analgesik menghilangkan rasa sakit, tanpa mempengaruhi penyebabnya. Nyeri merupakan sensasi yang mengindikasikan bahwa tubuh sedang mengalami kerusakan jaringan, inflamasi, atau kelainan yang lebih berat seperti disfungsi sistem saraf. Oleh karena itu nyeri sering disebut sebagai alarm untuk melindungi tubuh dari kerusakan jaringan yang lebih parah. Rasa nyeri seringkali menyebabkan rasa tidak nyaman seperti rasa tertusuk, rasa terbakar, rasa kesetrum, dan lainnya sehingga mengganggu kualitas hidup pasien atau orang yang mengalami nyeri.

Penelitian dilaksanakan di Rumah Sakit X Jakarta pada bulan November 2017 dengan

metode penelitian menggunakan deskriptif analitik dengan melihat data rekam medis pasien pasca operasi dengan metode retrospektif, serta pengambilan sampel dilakukan menggunakan metode purposive sampling periode Januari-Juni 2017.

Berdasarkan hasil yang telah diperoleh, ditemukan kejadian Drug Related Problem dengan kategori penggunaan obat tanpa indikasi sebanyak 1 pasien (7,59%). Dapat disimpulkan bahwa Pasien pasca operasi sebanyak 55,43% berjenis kelamin laki-laki dan 44,57% berjenis kelamin perempuan.Usia remaja sebanyak 11,96%, dewasa 48,91% dan lansia 39,13%  Jenis operasi major sebanyak 52,57% dan operasi minor 40,43%. Pola penggunaan obat yang diperoleh 38,04% digunakan turunan pirazolin, 35.87% turunan asam karboksilat pirolizin, 15,22% turunan asam asetat, 5,43% turunan fenamat, 3,26% turunan asam propionat, dan 2,18% turunan para aminofenol. Dosis yang digunakan dari setiap terapi secara keseluruhan telah sesuai.
EVALUASI PENGOBATAN PENYAKIT PARU OBSTRUKTIF KRONIK DI INSTALASI RAWAT JALAN RUMAH SAKIT UMUM XYZ JAKARTA BARAT
Authors: Ivans Panduwiguna  , Baniu Ahmad Sahlan , Renaldi Fransiskus Samuel , Hasan Anisatu Farhana , Tasmin Taufani
Published: July 2023

Telah dilakukan penelitian evaluasi penggunaan obat penyakit paru obstruktif kronik pada pasien di Instalasi Rawat Jalan Rumah Sakit Umum XYZ Jakarta Barat Periode Juli – Desember 2017. Tujuan penelitian ini untuk mengetahui pola penggunan obat PPOK dan mengetahui kesesuaian penggunaan obat PPOK di instalasi rawat jalan Rumah Sakit Umum XYZ Jakarta Barat dengan standar pelayanan medis dan pustaka. Jenis penelitian ini adalah menggunakan desain deskriptif, dengan melihat data rekam medis pasien PPOK sesuai dengan periode Juli – Desember 2017. Hasil penelitian ini menujukan bahwa pasien laki-laki sebanyak 44 pasien (65,67%) dan pasien perempuan sebanyak 23 pasien (34,33%). Golongan obat PPOK yang paling banyak digunakan adalah golongan beta- 2 agonis kerja singkat, terutama obat salbutamol yaitu digunakan oleh pasien 49 (21,30%). Terdapat 67 pasien yang mendapatkan dosis tepat (100%) dan tidak ditemukan adanya pasien yang menerima dosis kurang atau dosis lebih..
PROFIL PENGGUNAAN OBAT TRAMADOL DI INSTALASI HEMODIALISA RSU XYZ TANGERANG
Authors: Nugrahini Lestari , Rahman Reza Ismail Abdul , Abdillah Eric Kurnia , Hanama Khilda , Sufiyantini Sri , Tasmin Taufani
Published: July 2023

Evaluasi penggunaan obat (EPO) adalah suatu proses jaminan mutu yang sah dan terstruktural di rumah sakit dan dilakukan oleh suatu tim medik untuk memastikan bahwa obat digunakan secara tepat aman dan efektif. Tujuan dari penelitian ini adalah untuk mengevaluasi resep tramadol terhadap kesesuaian indikasi, dosis dan frekuensi pemberian tramadol pada pasien gagal ginjalpada pasien gagal ginjal di Rumah Sakit Umum XYZ Tangerang periode Januari–April 2017. Berdasarkan hasil penelitian evaluasi penggunaan tramadol di instalasihemodialisaRumah Sakit Umum XYZ Tangerang pada periode Januari–April 2017 Dari 50 pasien, penggunaan terbanyak adalah pasien dengan rentang usia masa manula yaitu 65 tahun keatas 18 pasien (36%), sedangkan pasien dengan jenis kelamin laki-laki sebanyak 26 pasien (52%).Penggunaan dosis satu kali pakai 50 mg sebanyak 30 dan frekuensi pemakaian dua kali sehari sebanyak 27 pasien (54%).Penggunaan tramadol pada pasien gagal ginjal di Rumah Sakit Umum XYZ Tangerang periode Januari–April 2017 sudah sesuai berdasarkan standar terapi pengobatan nyeri pada pasien gagal ginjal.
Impact of curricular internships in accounting on university students: an empirical study in Spain
Authors: Pérez-Espés Cristina , Cervera Oliver Mercedes , Cea D’Ancona Francisca
Published: July 2023

Various organizations, commissions and committees highlight the importance of teaching future accounting professionals through the combination of theoretical training and professional practice. The university must guarantee an accounting profession through graduates who can respond to the needs and global changes of the society. Curricular internships, conducive to experiential learning, allow the student to integrate classroom learning with professional practice, as well as to translate abstract theoretical concepts into reality. An increasing number of universities include the subject of internships within their curricula. All of this makes it interesting to analyse the impact these internships have on university students. This article presents, through factor analysis and the technique of structural equations, a model that comprehensively evaluates the impact of curricular internships in the accounting field on students. The information necessary to estimate the model was obtained through a questionnaire presented to students at the end of their internship period. The survey was completed by 279 students belonging to the Degrees in Business Administration and Management and in Economics at the Autonomous University of Madrid.

Diversas organizaciones, comisiones y comités destacan la importancia de la enseñanza de los futuros profesionales de la contabilidad mediante la combinación de la formación teórica y la práctica profesional. La universidad debe garantizar una profesión contable a través de graduados que puedan responder a las necesidades y cambios globales de la sociedad. Las prácticas curriculares, propicias para el aprendizaje experiencial, permiten al estudiante integrar el aprendizaje en el aula con la práctica profesional, así como trasladar a la realidad conceptos teóricos abstractos. Cada vez son más las universidades que incluyen la asignatura de prácticas dentro de sus planes de estudio. Todo ello hace interesante analizar el impacto que estas prácticas tienen en los estudiantes universitarios. En este artículo se presenta, mediante análisis factorial y la técnica de ecuaciones estructurales, un modelo que evalúa de forma exhaustiva el impacto de las prácticas curriculares en el ámbito contable sobre los estudiantes. La información necesaria para estimar el modelo se obtuvo a través de un cuestionario presentado a los estudiantes al final de su período de prácticas. La encuesta fue cumplimentada por 279 estudiantes pertenecientes a los Grados en Administración y Dirección de Empresas y en Economía de la Universidad Autónoma de Madrid.
Women in accounting: a historical review of obstacles and drivers on a patriarchal and classist path
Authors: Uribe Bohorquez Maria Victoria , García Sánchez Isabel María
Published: July 2023

This document, through a systematic review of academic papers, presents a comprehensive and synthetic proposal that compiles, on the one hand, the prevailing macho, misogynistic and phallocentric obstacles and stereotypes at the family, social and work level between the eighteenth and twentieth centuries and that had an impact on the accounting profession, hindering the access and evolution of women in it. In contrast, a series of factors are presented that drove the training and entry of women to bookkeeping and accounting tasks, which, in turn, served as a way to break stereotypes and traditional gender roles, achieve legislative improvements and the incursion of women into the paid labor market. Besides the above-mentioned elements, it is important to take into account the class perspectives that, under promises of well-being and economic status, idealized a model of a woman whose realization was exclusively at the domestic and family level.

Este documento, a través de una revisión sistemática de trabajos académicos, presenta una propuesta integral y sintética que recopila, por un lado, los obstáculos y estereotipos machistas, misóginos y falocéntricos imperantes a nivel familiar, social y laboral entre los siglos XVIII y XX y que repercutieron en la profesión contable, dificultando el acceso y evolución de la mujer en la misma. En contraposición, se presentan una serie de factores que impulsaron la formación e incorporación de la mujer a las tareas de teneduría de libros y contabilidad, lo que, a su vez, sirvió para romper estereotipos y roles tradicionales de género, conseguir mejoras legislativas y la incursión de la mujer en el mercado laboral remunerado. Además de los elementos mencionados, es importante tener en cuenta las perspectivas de clase que, bajo promesas de bienestar y estatus económico, idealizaron un modelo de mujer cuya realización se daba exclusivamente en el ámbito doméstico y familiar.
Inntrykk fra amerikansk strafferettspleie.
Authors: Andenæs Johs.
Published: July 2023

Intet resumé
Samhällsutveckling och nya brottstyper
Authors: Lithner Klas
Published: July 2023

Intet resumé
Om mentalundersøgelser i en 10-års periode
Authors: Vestergaard Emma
Published: July 2023

Intet resumé
Livsbrott begångna av barn under 15 ar i Finland
Authors: Katila O. , Hellsten P.
Published: July 2023

Intet resumé
Finsk, norsk kronik
Authors: Anttila Inkeri , Øie Ole-Erik
Published: July 2023

Intet resumé
Rettspsykiatrisk observerte omstreifere
Authors: Noreik Kjell
Published: July 2023

Intet resumé
Kriminologisk prognosforskning.
Authors: Börjeson Bengt
Published: July 2023

Intet resumé
Dansk, finsk, norsk, svensk kronik
Authors: Brydensholt H. H. , Anttila Inkeri , Øie Ole-Erik , Romander Holger
Published: July 2023

Intet resumé
Vetenskapsmetodik och kriminalpolitik
Authors: Bondeson Ulla
Published: July 2023

Intet resumé
Tilsiktet pine
Authors: Christie Nils
Published: July 2023

Intet resumé
Boganmeldelser
Authors: Koktvedgaard Mogens , Frände Dan , Nielsen Beth Grothe , Justesen Signe
Published: July 2023

Intet resumé
Danske domme af almindelig interesse september 1983-september 1987
Authors: Lindegaard Per
Published: July 2023

Intet resumé
Unge, der har begået alvorlig kriminalitet
Authors: Kramp Peter , Israelson Lise , Mortensen Karen Vibeke , Aarkrog Tove
Published: July 2023

Intet resumé
Alkohol og voldskriminalitet
Authors: Skog Ole-Jørgen , Bjørk Elisabeth
Published: July 2023

Intet resumé
Nyklassisisme, proporsjonalitet og prevensjon
Authors: Andenæs Johs.
Published: July 2023

Intet resumé
Dansk kronik 1986-87
Authors: Vestergaard Jørn
Published: July 2023

Intet resumé
Straffrätt och kriminalpolitik i DDR
Authors: Buchholz Erich
Published: July 2023

Intet resumé
Da organiseret kriminalitet blev indført til Danmark
Authors: Bay Joi
Published: July 2023

Organized crime was imported to Denmark within a few years during the 1990s when well-known forms of crime were redefined as organized crime. This article describes how organized crime was constructed as a social and criminal problem and how a certain, broad understanding of organized crime was institutionalized. The vehicle for the introduction of the concept organized crime and the implementation of organized crime as a phenomenon in Denmark was - on one hand - the growth of outlaw motorcycle gangs and - on the other hand - the increasing European Union cooperation in the legal field.
En plass for alle
Authors: Christie Nils
Published: July 2023

Intet resumé
O.J. Simpson - århundrets straffesak i USA. Noen refleksjoner fra TV-stolen
Authors: Eskeland Ståle
Published: July 2023

The author examines the evidence in the famous O.J. Simpson murder case where Simpson was acquitted. His conclusion is that the prosecution did prove beyond a reasonable doubt that Simpson was guilty. The author discusses some implications of the fact that Simpson was acquitted for reasons not related to the evidence in the case. He argues that it might be justified to acquit for other reasons than lack of evidence in cases where the political system is unable to solve severe conflicts in society or between individuals. In cases of unjustifiable violence, acquittals on other grounds than lack of evidence undermines the jury institution.
Om växelverkan mellan straffrätt och straffprocessrätt ur ett finländskt perspektiv
Authors: Frände Dan
Published: July 2023

Criminal law and procedural law have always been closely related. It is quite clear that these disciplines are highly dependent of each other. Every modern democracy needs a material as well as a formal side. One can, e.g., argue that a weak and undeveloped criminal procedure is a constant threat to the fundamental human rights and freedoms of the citizens. But is there an actual interaction between criminal law and criminal procedure? In my opinion, such an interaction exists. This is noticeable on a concrete level, i.a. in the submission of evidence. Dogmatic research, too, should always cover both fields. Whenever possible, the formation of rational concepts requires a terminology that is familiar to both criminal law and criminal procedure.
Professionalisme og forskning i kriminalforsorgen
Authors: Ingstrup Ole
Published: July 2023

This article adds a chapter to the history of the Correctional Service of Canada. The author touches upon a number of issues, most notably: 1) how the creation of a results driven, value based organisation develops a natural thirst for more knowledge and the desire to have its own research unit; 2) the importance of trust between practitioners and researchers; 3) the profile of "the ideal" research unit; 4) the need for broad internal-external collaboration; 5) the relationship between research and policy; 6) the organisation's responsibility towards its researchers; and 7) some of the correctional results achieved as a result of good internal research.
De grundläggande rättigheterna och straffrätten
Authors: Lahti Raimo
Published: July 2023

The Constitutional Rights Reform of 1995 in Finland introduced several provisions which are significant for criminal law. The most important of them is the section concerning the legality principle in criminal law. This section is equivalent to the corresponding articles in the European Convention on Human Rights and the UN Convent on Civil and Political Rights. In certain respects the Finnish provision is intended to be applied more strictly than the corresponding human rights articles. The definition of a crime and the prescription of a penalty must be based on an Act of Parliament. The use of so-called blanket provision techniques must also be reduced and specified.
The increasing emphasis on human and constitutional rights will obviously affect the Finnish criminal law theory and criminal policy. For instance, the moral and political arguments of justice and humanity, which play an important role in criminal law theory, have now a strong institutional support as legal principles, when being firmly attached to human rights and constitutional law.
Strafferet for kulier og for erhvervsliv
Authors: Nielsen Gorm Toftegaard
Published: July 2023

An attempt is made to set up a model in broad outline to illustrate the legal dogmatic differences between blue collar crime and white collar crime. The objective is to point out that blue collar crime raises only very few real juridical problems. Due to a belief that analyses on blue collar crime can be used on white collar crime, these problems are exaggerated in the theory of criminal law. It is recommended that theory to a larger extent should be based on facts and less on a belief in rules.
Ansvar utan klander?
Authors: Victor Dag
Published: July 2023

Is penal liability for legal persons compatible with the humanistic ideology of the Enlightenment period? In penal law, the principle of guilt has been seen as an expression of this ideology. The notion of personal guilt cannot be applied to legal persons. It makes, however, perfect sense to censure acts and omissions in the business activities of a legal person. There is a tendency to use sanctions against legal persons according to the principle of strict liability. Such liability is liability without guilt but also without censure. It is argued that in penal law the requirement of censure is more central than guilt as a protection against state power. In that sense, it is in accordance with the heritage of the Enlightenment period to favour penal liability for legal persons in order to uphold the requirement of censure, even if this is a divergence from the principle of guilt.
El código Atticus. Homenaje al profesor Javier de Lucas Martín
Authors: Rodríguez Uribes Jose Manuel
Published: July 2023

Son muchos los temas de investigación a los que se ha enfrentado con éxito y rigor Javier de Lucas en su larga vida académica. Desde la inmigración, el racismo y la xenofobia, a la desobediencia civil y la objeción de conciencia, pasando por su tesis doctoral sobre Durkheim o por sus trabajos sobre clásicos como Condorcet, el concepto de solidaridad, el de tolerancia, el principio de soberanía, la justificación paternalista del poder, el secreto y la transparencia o el principio kantiano de publicidad, entre otros muchos. Este breve artículo se centra sin embargo en un contenido muy concreto de su ingente obra: el código Átticus y su relación con el ideal del Estado de Derecho y la democracia.
Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis
Authors: Das Rajsekhar , Sinha Sumit , Li Xin , Kirkpatrick T. R. , Thirumalai D.
Published: July 2023

A recent experiment on zebrafish blastoderm morphogenesis showed that the viscosity (
η
) of a non-confluent embryonic tissue grows sharply until a critical cell density (
ϕ

S

). The increase in
η
up to
ϕ

S

is similar to the behavior observed in several glass forming materials, which suggests that the cell dynamics is sluggish or glass-like. Surprisingly,
η
is a constant above
ϕ

S

. To determine the mechanism of this unusual dependence of
η
on
ϕ
, we performed extensive simulations using an agent-based model of a dense non-confluent two-dimensional tissue. We show that polydispersity in the cell size, and the propensity of the cells to deform, results in the saturation of the available free area per cell beyond a critical density. Saturation in the free space not only explains the viscosity plateau above
ϕ

S

but also provides a relationship between equilibrium geometrical packing to the dramatic increase in the relaxation dynamics.
PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA
Authors: Jana Samarjit , Mondal Mainak , Mahale Sagar , Gupta Bhavana , Prasasvi Kaval Reddy , Kandasami Lekha , Jha Neha , Chowdhury Abhishek , Santosh Vani , Kanduri Chandrasekhar , Somasundaram Kumaravel
Published: July 2023

In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here we have identified a long noncoding RNA, PITAR (
p
53
I
nactivating
T
RIM28
a
ssociated
R
NA), as an inhibitor of p53. PITAR is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We found that TRIM28 mRNA, which encodes a p53-specific E3 ubiquitin ligase, is a direct target of PITAR. PITAR interaction with TRIM28 RNA stabilized TRIM28 mRNA, which resulted in increased TRIM28 protein levels, enhanced p53 ubiquitination, and attenuated DNA damage response. While PITAR silencing inhibited the growth of WT p53 containing GSCs in vitro and reduced glioma tumor growth in vivo, its overexpression enhanced the tumor growth and promoted resistance to Temozolomide. DNA damage also activated PITAR, in addition to p53, thus creating an incoherent feedforward loop. Thus, we establish an alternate way of p53 inactivation and propose PITAR, an oncogenic Cancer/testis lncRNA, as a potential therapeutic target.
Sleep Regularity and Mortality: A Prospective Analysis in the UK Biobank
Authors: Cribb Lachlan , Sha Ramon , Yiallourou Stephanie , Grima Natalie A , Cavuoto Marina , Baril Andree-Ann , Pase Matthew P.
Published: July 2023

Irregular sleep-wake timing may cause circadian disruption leading to several chronic age-related diseases. We examined the relationship between sleep regularity and risk of all-cause, cardiovascular disease (CVD), and cancer mortality in 88,975 participants from the prospective UK Biobank cohort.The sleep regularity index (SRI) was calculated as the probability of an individual being in the same state (asleep or awake) at any two time points 24 hours apart, averaged over 7-days of accelerometry (range 0-100, with 100 being perfectly regular). The SRI was related to the risk of mortality in time-to-event models.The mean sample age was 62 years (SD, 8), 56% were women, and the median SRI was 60 (SD, 10). There were 3010 deaths during a mean follow-up of 7.1 years. Following adjustments for demographic and clinical variables, we identified a non-linear relationship between the SRI and all-cause mortality hazard (
p
[global test of spline term] < 0·001). Hazard Ratios, relative to the median SRI, were 1·53 (95% confidence interval [CI]: 1·41, 1·66) for participants with SRI at the 5
th
percentile (SRI = 41) and 0·90 (95% CI: 0·81, 1·00) for those with SRI at the 95
th
percentile (SRI = 75), respectively. Findings for CVD mortality and cancer mortality followed a similar pattern.Irregular sleep-wake patterns are associated with higher mortality risk.National Health and Medical Research Council of Australia (GTN2009264; GTN1158384), National Institute on Aging (AG062531), Alzheimer’s Association (2018-AARG-591358), and the Banting Fellowship Program (#454104).
Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila
Authors: Sood Chhavi , Nahid Md Ausrafuggaman , Branham Kendall R. , Pahl Matthew C. , Doyle Susan E. , Siegrist Sarah E.
Published: July 2023

Neuroblasts in
Drosophila
divide asymmetrically, sequentially expressing a series of intrinsic factors to generate a diversity of neuron types. These intrinsic factors known as temporal factors dictate timing of neuroblast transitions in response to steroid hormone signaling and specify early versus late temporal fates in neuroblast neuron progeny. After completing their temporal programs, neuroblasts differentiate or die, finalizing both neuron number and type within each neuroblast lineage. From a screen aimed at identifying genes required to terminate neuroblast divisions, we identified Notch and Notch pathway components. When Notch is knocked down, neuroblasts maintain early temporal factor expression longer, delay late temporal factor expression, and continue dividing into adulthood. We find that Delta, expressed in cortex glia, neuroblasts, and after division, their GMC progeny, regulates neuroblast Notch activity. We also find that Delta in neuroblasts is expressed high early, low late, and is controlled by the intrinsic temporal program: early factor Imp promotes Delta, late factors Syp/E93 reduce Delta. Thus, in addition to systemic steroid hormone cues, forward lineage progression is controlled by local cell-cell signaling between neuroblasts and their cortex glia/GMC neighbors: Delta transactivates Notch in neuroblasts bringing the early temporal program and early temporal factor expression to a close.
CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting
Authors: Wu Yangyu , Yan Yangyang , Yang Youshan , Bian Shumin , Rivetta Alberto , Allen Ken , Sigworth Fred J
Published: July 2023

We present near-atomic-resolution cryoEM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and sodium-bound states at 3.2 Å, 2.5 Å, 3.2 Å, and 2.9 Å. These structures, all obtained at nominally zero membrane potential in detergent micelles, reveal distinct ion-occupancy patterns in the selectivity filter. The first two structures are very similar to those reported in the related Shaker channel and the much-studied Kv1.2–2.1 chimeric channel. On the other hand, two new structures show unexpected patterns of ion occupancy. First, the toxin α-Dendrotoxin, like Charybdotoxin, is seen to attach to the negatively-charged channel outer mouth, and a lysine residue penetrates into the selectivity filter, with the terminal amine coordinated by carbonyls, partially disrupting the outermost ion-binding site. In the remainder of the filter two densities of bound ions are observed, rather than three as observed with other toxin-blocked Kv channels. Second, a structure of Kv1.2 in Na+ solution does not show collapse or destabilization of the selectivity filter, but instead shows an intact selectivity filter with ion density in each binding site. We also attempted to image the C-type inactivated Kv1.2 W366F channel in Na+ solution, but the protein conformation was seen to be highly variable and only a low-resolution structure could be obtained. These findings present new insights into the stability of the selectivity filter and the mechanism of toxin block of this intensively studied, voltage-gated potassium channel.
Attitudes of medical students in Khartoum, Sudan towards the doctor-patient relationship: a cross-sectional study
Authors: Haiba Aya M. , Haiba Marwan M.
Published: July 2023

Background/Objectives

The doctor-patient relationship is essential to the delivery of high-quality medical care. A strong doctor-patient relationship that improves patient outcomes and satisfaction depends on effective communication. The purpose of this study was to assess medical students’ attitudes toward the doctor-patient relationship during their clinical years at the University of Khartoum. We also looked at how gender and study year affected patient-centeredness.

Participants/Setting

The study was conducted on medical students in their clinical years from December 2020 to March 2021. Students were selected from years 3 to 6. A total of 353 medical students constituted the study sample.

Design

The cross-sectional study utilized the Patient Practitioner Orientation Scale (PPOS) for the measurement of student attitudes towards the doctor-patient relationship. PPOS scores are calculated as a mean score that ranges from 1 (indicating doctor or disease-centered inclinations) to 6 (indicating patient-centered or egalitarian inclinations). Medical students’ demographic data was collected, including their gender, age and study year.

Results

A total of 313 students completed the survey (response rate: 89%). The average total PPOS score and the scores for the caring and sharing subscales for the entire cohort were 4.08 ± 0.53, 4.43 ± 0.58, and 3.72 ± 0.72, respectively. Female gender was significantly associated with more patient-centered attitudes (p < 0.001). When compared to the start of their clinical curriculum, students’ attitudes were significantly more patient-centered by the conclusion of their studies (p < 0.001).

Conclusion

A satisfactory level of patient-centeredness was demonstrated by medical students at the University of Khartoum, and gender had an impact on this quality. Additional consideration should be given to the finding that students’ orientations were more patient-centered in the caring dimension and less so in the sharing one. Once addressed, improvements in that area could create an environment that enhances attitudes among students in the sharing domain, with great potential gains to patients.
Terremotos, arquitectura y la Norma Chilena NCh433. Of.72. Cálculo Antisísmico de Edifcios (1959-1972)
Authors: Barrientos Marco
Published: July 2023

No presenta resumen.
Redefiniendo un paisaje productivo: La cosecha de áridos como detonante de un nuevo paisaje híbrido en la ribera del río Maipo
Authors: Castro Urrutia Montserrat Paz
Published: July 2023

No presenta resumen.
paisaje como recurso estratégico: Diseño de Ruta Turística en la provincia de Chañaral
Authors: Moreno Osvaldo , Arizaga Ximena , Gómez Tomás , Palacios Sebastián
Published: July 2023

No presenta resumen.
Estrategia espacial de control ambiental para la vivienda en altura en la zona central de Chile
Authors: Poblete Daniela
Published: July 2023

No presenta resumen.
Consumir para producir la ciudad: Arquitectura de consumo y urbanismo de retail en la ciudad chilena
Authors: De Simone Liliana
Published: July 2023

No presenta resumen.
Hacia un Atlas Cartográfico de la ex Frontera: El sistema defensivo del Biobío a través de cuatro lecturas en el tiempo
Authors: Figueroa P Arantxa
Published: July 2023

No presenta resumen.
Entre Trapananda e Hidroaysén Territorio y Nación en la conformación de las fi guras culturales del paisaje de Aysén, Patagonia chilena. 1902-2018
Authors: Rossetti Fulvio
Published: July 2023

No presenta resumen.
Ciudades irrigadas: flujos de agua y movilidad en la ciudad de Valdivia
Authors: Alberti Catalina
Published: July 2023

No presenta resumen.
Planificación territorial del turismo en Yugoslavia y la definición de un borde costero en cuatro escalas
Authors: Basauri Luciano
Published: July 2023

No presenta resumen.
Río Mapocho aguas abajo: paisaje [alterado] en proceso.
Authors: Brito Raúl
Published: July 2023

No presenta resumen.
infraestructura hotelera en Chile y su relación con Argentina.
Authors: Cortés María Macarena , Vergara Luz María , Puig Anita María
Published: July 2023

No presenta resumen.
escuela-bus: un proyecto político y territorial
Authors: Celedón Alejandra , Gómez Francisca
Published: July 2023

No presenta resumen.
Rappiscapes: efectos urbanos del comercio digital para pedir bienes y servicios a domicilio
Authors: Ivin Ivana
Published: July 2023

No presenta resumen.
Assessing Smallholder Households’ Perception towards Effectiveness of Agricultural Extension and Advisory Services in Ensuring Food Security during COVID-19
Authors: Krithika S. , Karthikeyan C.
Published: July 2023

The study aims to assess the farm households’ perception towards Agricultural Extension and Advisory Services (EAS) during the pandemic and identify the socio-economic factors influencing the perception of smallholder households in selected rural areas of Tamil Nadu. For the purpose of the research, 270 rural households belonging to farm families were selected through a multistage stratified random sampling method. The perception towards EAS effectiveness was assessed based on parameters such as communication, technological interventions and mobilizing farmers. The results revealed that information about government schemes was perceived to be the more effective intervention of EAS with a mean rank of 2.29 followed by online training activities (Mean rank of 2.16). Socio-economic characteristics such as education, livestock holding, landholding and income of the households were the significant factors that influenced perception. The results also revealed that 64% of households perceived Extension and Agricultural Services as moderately effective during COVID-19. The results could be improved further by adopting specific interventions such as public-private partnerships, nutrition-oriented extension activities such as promoting nutritive gardens, the use of Information and Communication Technologies (ICT) and promoting gender equality for improving food security of the farm households. Future studies can be done on the impact of the pandemic on pluralistic agricultural systems.
The Influence of Cassava Mill Effluents on Soil Microbial Community in Akpabuyo, Cross River State, Nigeria
Authors: Akubuenyi F. C.
Published: July 2023

The influence of cassava mill effluent on the microbial community of the soil was determined using viable counts method. Soil samples were collected from different sites (Locations A, B, C and D) impacted with cassava mill effluent, and also from sites unimpacted with cassava mill effluent, which served as control. The result of analysis of the impacted soil showed that the counts of Total Heterotrophic Bacteria, Total Coliforms and Total Fungi ranged from 2.0x103 CFU/ml to 2.3x104 CFU/ml, 1.9x102 CFU/ml to 1.5x104 CFU/ml and 1.4x102 CFU/ml to 2.2x102 CFU/ml respectively. These values were lower compared to the values (3.4x105 CFU/g to 3.6x106 CFU/g, 2.1x106  CFU/g to 3.3x106 CFU/g and 2.1x104 CFU/g to 3.0x104 CFU/g respectively) obtained from the unimpacted soils (control). The identification process of the isolates revealed the presence of the following bacteria; Bacillus spp., Micrococcus spp., Klebsiella spp., Pseudomonas spp., Staphylococcus spp., Salmonella spp. The fungal isolates from the effluents were identified to be Aspergillus spp., Rhizopus spp. and Mucor spp. The results obtained indicates that effluents from cassava mill effluent have a great impact on the microbial population of the soil. Since its application causes change that affects the microbial population and diversity, its continuous disposal could lead to decreased soil fertility and consequent low crop yield. Therefore, cassava mill effluents should be subjected to treatments that reduces their harmful substance content before disposal.
Heat Waves and Its Impact on Crop Production and Mitigation Techniques: A Review
Authors: Singh Divya , Yadav Atish , Singh Shubhendu , Yadav Rishi Kumar , Sen Mrinal , Yadav Amrendra Kumar , Gehlot Tanisha , Mishra Abhishek , Pandey Vaibhav , Singh Anil Kumar
Published: July 2023

Globally, heat waves are getting worse and more common. India experienced its warmest March and April on record, with maximum and minimum temperatures unusually rising in most of the nation. In 10 out of the 36 meteorological subdivisions during this time, the extreme temperatures were found to be higher by +8 to +10.8°C and the rainfall lower by -60 to -99 percent, respectively, compared to normal. Additionally, 2022 will be remembered as a prime example of the combined effects of high temperatures and low rainfall on agricultural production systems, particularly in northern and central India. Climate variability and change have an impact on India's agricultural production. In the states of Punjab, Haryana, and Rajasthan, abnormally high maximum and minimum temperatures in 2022 had an impact on livestock, crops, and fruits and vegetables. Himachal Pradesh, Uttar Pradesh, Madhya Pradesh, Bihar, and Maharashtra, as well as Jammu and Kashmir. The heat wave coincided with the wheat crop's grain filling and development stage, causing the grain to yellow and shrivel, forcing it to mature, and lowering yields by 15 to 25 percent. A variety of technologies are available to reduce the yield loss in wheat caused by a heat wave, and some of them have been implemented on farmer fields. As compared to the local variety HD-3086, several heat-tolerant wheat varieties, including PBW 803, DBW 187, and DBW 222, can withstand high temperatures while still producing normal yields.
Analysis of Heterotic Potential for Yield and Its Contributing Traits in Wheat (Triticum aestivum L.)
Authors: Reddy B. Ramesh Kumar , Kumar Bijendra , Kumar Rajneesh , Thota Harshita
Published: July 2023

Fifty-six genotypes were evaluated comprising 45 hybrids, 10 parents and 1 standard check (HD2968) were evaluated in a randomized block design (RBD) with three replications for 12 traits viz. Days to 50 % flowering, days to maturity, plant height, number of tillers per plant, spikelets per spike, ear length, spike density, number of ears per plant, number of grains per ear, seed index, grain yield per plant and harvest index to study the magnitude and direction of heterosis for yield and earliness in wheat. Significant heterosis was found over mid parent and commercial checks for all the traits studied in desirable direction. The findings revealed highly significant differences between parents and F1’s as well as among parents for the majority of attributes. In the present research investigation, the number of days taken for 50 % flowering and days to maturity was selected as indicative of earliness. Among 45 crosses, K1317 x HD2967 expressed negative significant heterosis over mid parent and standard check respectively, for days to 50% flowering while Cross HD3059 x DBW3059 revealed highly significant negative heterosis for days to maturity. In present research, the highest positive and significant heterosis over mid parent was exhibited by cross DBW187 x HI153 followed by DBW187 x DBW3059, HD3294 x DBW3059. The cross DBW187 x DBW3059 followed by DBW187 x HD3059, HD3294 x K1601 shows highly positive heterotic percent for grain yield per plant over standard check. These hybrids may further be tested over various locations before release for commercial cultivation. High estimates of heterosis obtained in hybrid combinations revealed considerable genetic divergence among the parental lines and reveals good scope for commercial exploitation of heterosis in wheat.
Estudo Comparativo: arbitragem luso-brasileira de conflitos de propriedade intelectual
Authors: Borges Yohanna Marêssa Alves , Borges Nayara Andressa Alves , Borges Kelly Cristina Alves , Ghesti Grace Ferreira
Published: July 2023

A arbitragem tem sido uma ferramenta fundamental na resolução de controvérsias envolvendo a propriedade intelectual, devido ao fato de propiciar acordos internos com privacidade, flexibilidade e redução de custos para as partes conflitantes. Nesse sentido, o presente trabalho objetivou analisar de forma comparativa a utilização da arbitragem nos conflitos de propriedade intelectual envolvendo as marcas em dois sistemas jurídicos presentes nos países Brasil e Portugal. A pesquisa comparativa, realizada por meio da utilização das métricas provenientes da ferramenta jurídica denominada direito comparado aliado à matriz FOFA, serviu de base para a análise e a comparação dos sistemas jurídicos de ambos países. Desse modo, conclui-se que o Brasil ainda enfrenta muitas barreiras, que precisa transpor, em matéria de arbitragem aplicada ao direito marcário. O principal resultado obtido evidenciou que Portugal está mais bem preparado para tratar da arbitragem na resolução de conflitos que tenham como temática as marcas.
Um Panorama do Uso da Proteção por Desenho Industrial no Setor de Saúde
Authors: Peralta Patricia Pereira , Silva Elizabeth Ferreira da , Rio Eduardo Rodrigues
Published: July 2023

O design revela-se como um instrumento na diferenciação e na agregação de valor em todos os setores, podendo ser protegido pelo registro de desenho industrial, o que possibilita gerar informações que permitam caracterizar os usuários do sistema. O objetivo deste artigo foi analisar o uso da proteção de desenhos industriais no setor de saúde, promovendo um panorama desse uso no Brasil e no cenário internacional. Metodologicamente, partiu-se de uma perspectiva exploratória e qualitativa, utilizando as bases de dados de desenhos industriais do Instituto Nacional da Propriedade Industrial (INPI), bem como da Organização Mundial da Propriedade Intelectual (OMPI), de maneira a traçar um panorama. Como conclusões, foi possível atestar o reduzido uso desse sistema por residentes, identificar aqueles países que possuem maior interesse em proteger suas criações dentro de nosso mercado e constatar os maiores usuários internacionais do sistema de proteção por desenho industrial, no Brasil, no setor de saúde.