bluuebunny/crossref_metadata_2025 huggingface dataset:
A 35-Gene Expression Profile Test for use in Suspicious Pigmented Lesions Impacts Clinical Management Decisions of Dermatopathologists and Dermatologists
Authors: Farberg Aaron , Ahmed Kelli , Bailey Christine , Russell Brooke , Douglas Kelly , Johnson Clare , Zolochevska Olga , Cook Robert , Goldberg Matthew
Published: November 2020

Purpose: Histopathological examination is sufficient for diagnosis of many melanocytic neoplasms, however, diagnostic discordance is common between dermatopathologists. A timely and confident diagnosis is optimal, especially in cases where both benign and malignant melanocytic neoplasms are considered in the differential diagnosis as treatment plans diverge significantly.
A 35-gene expression profile (GEP) test that classifies melanocytic lesions into categories (benign, intermediate-risk and malignant), has reported accuracy metrics of 99.1% sensitivity, 94.3% specificity, 93.6% positive predictive value and 99.2% negative predictive value in a validation cohort of 503 samples. The clinical utility of the 35-GEP is described.
Methods: Dermatopathologists (n=6) and dermatologists (n=14) were queried regarding diagnostic challenges and patient management strategies in 60 difficult-to-diagnose melanocytic neoplasms. Participants reviewed each lesion twice, once without the 35-GEP result and once with. Responses were evaluated for consistent trends in the utilization of the 35-GEP test result.
Results: Dermatopathologists utilized the 35-GEP result to refine their diagnoses by increasing overall lesion diagnostic concordance and confidence, while reducing additional work up requests. Dermatologists utilized the 35-GEP result to gauge overall prognosis and case difficulty. Alterations in office visit frequency, biopsies, and referrals to specialists were also influenced by the 35-GEP result and treatment plan modifications also matched the appropriate directionality of the 35-GEP result.
Conclusions: The diagnosis of challenging melanocytic neoplasms and subsequent clinical management decisions are influenced by 35-GEP results in a manner that agrees with the test result. The utility of the test provides the opportunity to improve patient care.
Baseline Characteristics of Atopic Dermatitis (AD) and AD Treatments in a Cohort of Adult AD Patients Initiating Dupilumab in a Real-World Registry (PROSE)
Authors: Shrager Daniel , Guenthner Scott , Cohen David , Zhang Haixin , Richman Daniel , Korotzer Andrew , Bansal Shikha
Published: November 2020

Abstract not available.
Review of Mechanisms of Release of Commonly Prescribed Tetracyclines
Authors: Kwong Pearl , Baldwin Hilary , Glaab Debbie , Schreiber Rhonda , Hignett Emma
Published: November 2020

Abstract not available.
A Comparative Clinical Demonstration of the Spreadability of Tazarotene Lotion 0.045% versus Trifarotene Cream 0.005%
Authors: Draelos Zoe , Tanghetti Emil
Published: November 2020

Abstract not available.
Tapinarof Cream 1% QD for the Treatment of Plaque Psoriasis: Efficacy and Safety in Two Pivotal Phase 3 Trials
Authors: Lebwohl Mark , Stein Gold Linda , Strober Bruce , Armstrong April , Hong H Chih-Ho , Kircik Leon , Soung Jennifer , Fromowitz Jeff , Guenthner Scott , Piscitelli Stephen , Rubenstein David , Brown Philip , Tallman Anna , Bissonnette Robert
Published: November 2020

Abstract not available.
Phase IV Open Label Evaluation of the Adrenal Suppression Potential and Pharmacokinetic Properties of Twice Daily Halobetasol propionate Foam, 0.05% in Adolescent Subjects with Plaque Psoriasis
Authors: Hebert Adelaide , Schrieber Rhonda , Glaab Debbie , Eichenfield Lawrence
Published: November 2020

Abstract not available.
Durability of DLQI Improvements Among Patients with Moderate to Severe Plaque Psoriasis Treated with Certolizumab Pegol: Three-Year Results from Two Phase 3 Trials (CIMPASI-1 and CIMPASI-2)
Authors: Blauvelt A , Warren RB , Reich K , Brock F , Fierens F , Ciaravino V , Lebwohl M
Published: November 2020

Abstract not available.
Efficacy and Safety of Ruxolitinib Cream for the Treatment of Atopic Dermatitis: Results From Two Phase 3, Randomized, Double-Blind Studies
Authors: Papp Kim , Szepietowski Jacek C. , Kircik Leon , Toth Darryl , Kuligowski Michael E. , Venturanza May E. , Sun Kang , Simpson Eric L.
Published: November 2020

Abstract not available.
Complete relief of vasospasm – Effect of nicardipine coating during direct clipping for the patient with symptomatic vasospasm of subarachnoid hemorrhage
Authors: Yokoya Shigeomi , Hino Akihiko , Goto Yukihiro , Oka Hideki
Published: November 2020

Background:

Some patients come to the hospital presenting with ischemic neurological deficits due to postsubarachnoid hemorrhage (SAH) cerebral vasospasm. In such a situation, neurosurgeons tend to avoid direct clipping, since mechanical irritation to the vessels could worsen the vasospasm and exacerbate ischemic symptoms. The optimal timing of direct clipping in patients with evidence of vasospasm is undetermined. Herein, we present the case of a patient who underwent direct clipping in the presence of severe symptomatic and post-SAH angiographic vasospasm. During surgery, we coated the severely spastic artery with nicardipine.

Case Description:

A 49-year-old woman was admitted to our hospital with the diagnosis of ruptured intracranial aneurysm and severe vasospasm. On the admission day, we performed direct clipping together with direct application of nicardipine to the spastic artery. Postoperative immediate cerebral angiography showed complete disappearance of the vasospasm.

Conclusion:

Direct clipping should not be contraindicated during the vasospasm period in patients with a ruptured aneurysm, and direct application of nicardipine on the spastic artery would completely relieve vasospasm.
Implementasi Metode National Institute of Justice (NIJ) Pada Fitur TRIM SOLID STATE DRIVE (SSD) Dengan Objek Eksperimental Sistem Operasi Windows, Linux dan Macintosh
Authors: Ramadhan Rizdqi Akbar , Mualfah Desti
Published: November 2020

Solid State Drive (SSD) merupakan solusi terkni untuk mempercepat pemrosesan data dari berbagai komputer desktop yang bersifat multiplatform. Fitur TRIM yang ada pada SSD berguna untuk menghilangkan garbage data yang dihapus permanen oleh user, dimana metode ini memiliki benefit untuk memperpanjang usia pakai dari perangkat SSD. Kontradiksi dari penggunaan metode ini adalah sulitnya bagi investigator forensik untuk melakukan recovery data yang telah terhapus apabila terjadi praktek cyber crime dalam kasus barang bukti berupa komputer dengan storage SSD. Objek eksperimen dalam penelitian ini berdasarkan perspektif sistem operasi mainstream yaitu Windows, Linux dan Macintosh yang terinstall pada SSD dimana pada masing-masing sistem operasi dilakukan simulasi penghapusan data yang tersimpan dengan perbandingan konfigurasi TRIM enable dan TRIM disable. Metode Digital Forensik yang diimplementasikan pada hal ini adalah National Intitute of Justice (NIJ) dimana metode ini berlaku sebagai acuan dalam praktek Digital Forensik pada penelitian ini. Perangkat lunak SLEUTH KIT Autopsy merupakan perangkat Digital Forensik yang digunakan dalam perspektif investigator dalam akusisi dan analisis barang bukti SSD pada simulasi kasus penelitian ini. Novelti yang didapatkan pada konten penelitian adalah sistem operasi yang menjadi objek eksperimen merupakan sistem operasi Windows, Linux, dan Macintosh rilis terkini yang tentunya memiliki potensi yang besar dalam hal eksplorasi, khususnya Digital Forensik. Windows memiliki peluang hasil recovery paling besar diantara 2 sistem operasi lainnya dalam penelitian ini.
Direct Monitoring of Bicarbonate Transport by Emission Spectroscopy
Authors: Martínez-Crespo Luis , Hewitt Sarah , Alessandro De Simone Nicola , Sindelar Vladimir , Davis Anthony P. , Butler Stephen , Valkenier Hennie
Published: November 2020

The transmembrane transport of bicarbonate is a key step in many important biological processes, while problems with bicarbonate transport are at the origin of various diseases. Over the past 10 years, many anionophores that have been developed for the transport of chloride, have also been tested as bicarbonate transporters. However, methodology to directly monitor the kinetics of transport of bicarbonate is lacking, hence indirect methods have been used, which mainly rely on the monitoring of chloride concentrations.Here we present an assay that allows the kinetics of bicarbonate transport into liposomes to be monitored directly, using emission spectroscopy. The assay utilises an encapsulated europium(III) complex, which exhibits a large increase in emission upon binding of bicarbonate. The advantages of this assay over existing methodology are that concentrations of bicarbonate are monitored directly and with a high sensitivity. This allows studies at very low concentrations of anionophores, and for the mechanisms of bicarbonate transport to be unravelled. We have distinguished classical antiport with bicarbonate from mechanisms involving CO2 diffusion and the dissipation of a pH gradient. Furthermore, the use of a standard fluorescence spectrometer and liposomes with a diameter ~200 nm makes this assay readily and reliably applicable in many laboratories, where it can facilitate the development of bicarbonate transporters for applications in physiological studies or therapies.
Unentangled Vitrimer Melts: Interplay between Chain Relaxation and Cross-link Exchange Controls Linear Rheology
Authors: RICARTE RALM , Shanbhag Sachin
Published: November 2020

Using this theoretical approach, we explore the influence of molecular structure and temperature on vitrimer linearviscoelasticity. We observe that vitrimers with uniform and random cross-link distributions exhibit larger viscositiesand relaxation times than gradient and blocky types. Polydimethylsiloxane vitrimer (which has a flexible backbone) shows an Arrhenius temperature dependence for viscosity, while polystyrene vitrimers (which has rigid backbones) are only Arrhenius at high temperatures. During stress relaxation, the short time dynamics represent monomer friction, while the long time dynamics encompass a combination of network strand relaxation and cross-link exchange. Because of the different temperature dependences of the processes, time-temperature superposition fails. We also show that the effective rheological activation energy can be estimated a priori using only the cross-link exchange activation energy and the backbone Williams-Landel-Ferry parameters.

(Submitted to Macromolecules)
Retrained Generic Antibodies Can Recognize SARS-CoV-2
Authors: Han Yanxiao , McReynolds Katherine , Kral Petr
Published: November 2020

The dramatic impact which novel viruses can have on the human society could be mitigated without the need of vaccination if antibodies present within the population are retrained to recognize these viruses. With this idea in mind, a double-faced peptide-based boosters are computationally designed to allow recognition of SARS-CoV-2 by Hepatitis B antibodies. One booster face is made of ACE2-mimic peptides that can bind to the receptor binding domain (RBD) of SARS-CoV-2. The other booster face is composed of a Hepatitis B core-antigen, targeting the Hepatitis B antibody fragment. Molecular dynamics simulations revealed that the designed boosters have a highly specific and stable bindingboth to RBD and the antibody fragment (AF). This approach can provide a cheap and efficient neutralization of emerging pathogens.
Rapid Access to Diverse Potassium Acyltrifluoroborates (KATs) Through Late-Stage Chemoselective Cross-Coupling Reactions
Authors: Deng Xingwang , Zhou Guan , Han Xiao , Ullah Khadim , Srinivasan Rajavel
Published: November 2020

Potassium acyltrifluoroborates (KATs) are opening up new avenues in chemical biology, materials science and synthetic organic chemistry due to their intriguing reactivities. However, the synthesis of these compounds remains mostly complicated and time-consuming. This lack of a rapid and facile synthetic route has hindered the widespread adoption of KAT-based chemistry, especially in the areas of compound library synthesis and drug discovery. Herein, we have developed chemoselective Pd-catalyzed approaches for the late-stage diversification of arenes bearing pre-functionalized KATs. These approaches feature chemoselective cross-coupling, rapid diversification, functional group tolerance, mild reaction conditions, and high yields.
Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C−H/C−H Coupling: Four-Step Total Synthesis of (±)-Russujaponol F
Authors: Zhuang Zhe , Herron Alastair , Liu Shuang , yu jin-quan
Published: November 2020

The development of practical C−H/C−H coupling reactions remains a challenging yet appealing synthetic venture because it circumvents the need to prefunctionalize both coupling partners for the generation of C−C bonds. Herein, we report a cyclative C(sp3)−H/C(sp2)−H coupling reaction of free aliphatic acids enabled by a cyclopentane-based mono-N-protected β-amino acid ligand. This reaction uses inexpensive sodium percarbonate (Na2CO3·1.5H2O2) as the sole oxidant, generating water as the only byproduct. A range of biologically important scaffolds, including tetralins, chromanes, and indanes, could be easily prepared by this protocol. Finally, the synthetic application of this methodology is demonstrated by the concise total synthesis of (±)-russujaponol F in a four-step sequence starting from readily available phenylacetic acid and pivalic acid through the sequential functionalizations of four C−H bonds.
A Directive Ni Catalyst Overrides Conventional Site-Selectivity in Pyridine C–H Alkenylation
Authors: Zhang Tao , Luan Yu-Xin , Lam Nelson , Li Jiang-Fei , Li Yue , Ye Mengchun , yu jin-quan
Published: November 2020

A remote C3–H activation of pyridine-containing substrates can be achieved with a directive Ni catalyst. The bifunctional NHC ligand incorporates an Al-binding side-arm that recruits and orients the substrate leading to the assembly of the requisite macrocyclophane transition state through reversible coordination. This assembly not only induces the reactivity of the otherwise unreactive Ni catalyst, but also overrides the intrinsic C2/C4 electronic bias of the Al-bound pyridine substrate, allowing for the first time, the C3 alkenylation of a variety of pyridine and heteroarene substrates as the limiting reagent.
The role of gender, age and localization in the clinical manifestation of the cerebral bifurcational-hemodynamic arterial aneurysms
Authors: Lytvak S.O. , Eleinik M.V. , Yakovenko L.M. , Malysheva T.A.
Published: November 2020

Objective ‒ to evaluate the influence of age, gender and localization on the clinical manifestation of cerebral bifurcational-hemodynamic arterial aneurysms (AA).Materials and methods. The retrospective study is based on the results of a comprehensive examination and surgical treatment of 547 (100 %) patients with bifurcational-hemodynamic cerebral AA in the Department of neurosurgical pathology of head and neck vessels of Romodanov Neurosurgery Institute during the period from 2011 till 2019. Recruiting of the patient to the clinical groups was done during the period between 2011‒2016 with their follow-up examination until 2019. It were enrolled 268 ((49.0 ± 4.2) %) men and 279 ((51.0 ± 4.2) %) women with bifurcational-hemodynamic aneurysms. The age of the patients was 18‒84 years (mean age ‒ 49,0±12,2 year).Results. Clinical manifestation of the cerebral bifurcational-hemodynamic AA was more often seen in patients during working age (16‒60 years) — 430 ((78.5 ± 3.4) %) patients, more often in men (p˂0.05). The peak frequency of clinical manifestation of AA ‒ 34.2 % (187 patients) was seen in the age interval 51‒60 years (the male/female ratio ‒ 51.3 % (96) and 48.7 % (91)). In patients with AA, a significant predominance of women was observed in age group older 61 years (χ2 = 21.68, p <0.001, φ = 0.20). There was no statistically significant relationship between the frequency of clinical manifestation of AA and the patient’s age. However, there is a statistically significant relationship between gender and age in some locations. The percentage of patients with AA complex of the anterior cerebral-anterior communicating artery among women is 62.5 ± 15.0 (25/40, after 60 years it’s in 1.7 times higher than among men 37.5 ± 15.0 (15/40). While before the age of 61, there is a 1.6-fold increase in men, 61.3 ± 7.5 (100/163). For the internal carotid artery segments, the percentage of patients who underwent AA among women is 81.6 ± 12.0 (31/38), after 60 years it is in 4.4 times higher than among men 18.4 ± 12.0 (7/38). For the middle cerebral artery, the percentage among women is 73.1 ± 17.4% (19/26), after 60 years it is in 2.7 times higher than in men 6.4 ± 17.7% (7/26). Until the age of 61, the gender difference in the internal carotid artery and the middle cerebral artery segments does not reach a statistically significant level (p> 0.05). At other localizations, gender-age dependence was not observed. Multiple cerebral aneurysmal lesions were associated with clinical manifestation at the age of 41‒50 years in males with 3 AA.Conclusions. A statistically significant influence of age, gender and the presence of multiple cerebral AA on the clinical manifestation of the disease was revealed. Localization of AA did not affect the timing of the clinical manifestation.
INTRA as a tool for comprehensibility
Authors: KALEM BAKKAL Aslı
Published: November 2020

This article aims to discuss intralingual translation based on the concept of comprehensibility. The framework of the study will be drawn by three articles: “Optimising comprehensibility in interlingual translation: The need for intralingual translation” by Matilde Nisbeth Jensen (2015), “Retranslation (re)visited” by Isabelle Desmidt (2009) and “Intralingual translation: An attempt at description” by Karen Korning Zethsen (2009) which will serve as the reference point. The idea of intralingual translation as a tool that optimizes comprehensibility in interlingual translation put forward by Matilde Nisbeth Jensen will be used as the starting point, whereas Isabelle Desmidt’s study, which questions the retranslation hypothesis developed by Antoine Berman (1990), will serve as the point of departure for the discussion in this paper. This article which argues that each intralingual translation following the very first translation is a retranslation, just like in the case of interlingual translation, is based on the view that comprehensibility, which is considered mainly within the framework of functional texts, can be said to be also one of the main factors driving intralingual translation of old Turkish classics. The paper that selects Gulyabani by Hüseyin Rahmi Gürpınar (1912) as its object of study discusses the intralingual translation in Turkey from the perspective of retranslation hypothesis, taking comprehensibility as the benchmark to evaluate the ‘distance’ between a literary source text and its retranslations.
Are residents learners or workers? A historical perspective in Japan
Authors: Fujikawa Hirohisa , Son Daisuke , Eto Masato
Published: November 2020

Many countries enforce limits on the number of hours that medical residents work. For example, in the United States, regulations about duty hours were instituted by the Accreditation Council of Graduate Medical Education as early as in 2003, reinforcing those limits in 2011 and again in 2017 (Accreditation Council for Graduate Medical Education, 2017). These reforms triggered discussion in medical education literature about their wide-ranging effects on resident education, resident wellness, and patient care (Bolster & Rourke, 2015).

In Japan, restrictions on working hours will be implemented for physicians in April 2024 (Shibuya & Unno, 2019). Because of its rapidly shifting demographics to being a super-aged society with a low birth rate, Japan is now facing issues with residents’ learning and working that other countries will need to confront in the near future as their populations shift as well (as of late 2020). Here we report on the history and current situation of postgraduate medical education in Japan, which are highly relevant to re-evaluating postgraduate training in other countries.
MEASUREMENTS OF RHEOLOGYCAL AND MECHANICAL-, THERMO-MECHANICAL PROPERTIES OF PVC/CORN COB FOAM COMPOSITE
Authors: Roman Krisztina , Zsoldos Gabriella
Published: November 2020

In this paper, the modification of PVC/Corn cob blends was investigated. Rheological and diffusion properties of blends are important to learn the behavior of blend’s in molten state, because it will provide information necessary for the processing. Nowadays, the development of biomaterials has become a primary goal for material engineers. Using materials from natural sources gives an option to modify PVC structures and properties. The following mechanical properties of the prepared composite were determined; tensile-, bending strength and hardness. The PVC/Corn cob blends have increased impact strength and the other mechanical properties can be improved as well. The relationship between the morphology and properties of the foam were also investigated. The result of DSC and dynamic mechanical analysis showed that the blends form a partially compatible system. The rheological analysis showed that the PVC composite with corn cob could be processed and recycled using regular thermoplastic processing systems.
Potency of Ethanol Extracts Palm Seeds (Phoenix dactylifera L.) as Antidiabetic with Inhibition Kinetics Parameter
Authors: Giovanny Lisa , Lestari Faliha Arinda , Marfira Nurul , Ambarsari Laksmi , Warnasih Siti
Published: November 2020

Dates seeds are one of the byproducts of the date palm juice industry which has the potential for further processing. Dates seeds contain active compounds that are known to have ability to inhibit αglucosidase. This study aims to measure the activity of 70% ethanol extract and the fraction of date palm seeds with a mechanism in inhibiting αglucosidase. The measurement of inhibitory activity was carried out by extracting date palm seeds using 70% water and ethanol. The extraction product is then fractionated with n-hexane, ethyl acetate, n-butanol, and water. Then the total phenolic and flavonoid calculations were calculated for each extract and fraction. Measurement of α-glucosidase inhibition activity was measured based on reaction of substrate to enzyme by the addition of inhibitors. The results showed that the ethanolextract had the highest total phenolic and flavonoid, which were 76.86 mg GAE / g and 21.19 mg QE / g, respectively. n-hexane fraction have the best inhibitory activity seen from the IC50 value, which is 12.69 mg/L. The kinetics of inhibition of 70% ethanol extract of date palm seeds are mixed inhibition.

Keywords: α-glucosidase, date seeds, flavonoids, kinetic inhibition, phenolics
STRATEGI PENERAPAN KONSEP SUSTAINABLE TOURISM DI DESA WISATA SESAOT KECAMATAN NARMADA LOMBOK BARAT
Authors: Ahmad Ramli
Published: November 2020

Penelitian ini dilaksanakan di Desa Wisata Sesaot Kecamatan Narmada Kabupaten Lombok Barat. Tujuan dilakukan penelitian ini adalah untuk mengetahui bagaimana Strategi Penerapan Konsep Sustainable Tourism di Desa Wisata Sesaot Kec Narmada Kab Lombok Barat.

Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan metode deskriptif. Metode analisis data yang digunakan untuk menganalisis data pada penelitian ini alat analisis SWOT (Strong, Weakness, Opportunity, dan Threat).

            Hasil penelitian ini menemukan Faktor Pendorong Penerapan Konsep Sustainable Tourism di Desa Wisata Sesaot. yang memperoleh kategori sangat tinggi adalah penataan desa wisata yang sangat indah dan asri, keindahan budaya (penduduk muslim dan hindu hidup berdampingan), sumber air melimpah, memiliki keunggulan produk perkebunan (buah-buahan), lokasi yang tidak terlalu jauh dari pusat kota. Faktor penghambat Penerapan Konsep Sustainable Tourism di kawasan wisata memperoleh rata-rata dengan kategori tinggi adalah rendahnya SDM masyarakat dalam pengembangan desa wisata, promosi dan pemasaran wisata kurang optimal, fasilitas di lokasi yang kurang memadai, kurangnya tenaga ahli dalam pengelolaan kawasan wisata dan kurangnya partisifasi pemerintah dalam pengembangan potensi desa.
ANALISIS POTENSI EKONOMI PADA SETIAP KECAMATAN DALAM PENGEMBANGAN PEMBANGUNAN EKONOMI DI KABUPATEN LOMBOK UTARA
Authors: Putu Karismawan  , Muhammad Alwi  , Baiq Ismiwati
Published: November 2020

Identifikasi potensi ekonomi pada setiap kecamatan di Kabupaten Lombok Utara sangat penting untuk dapat membuat perencanaan pembangunan yang tepat sehingga pengembangan pembangunan ekonomi dapat tumbuh dengan cepat. Tujuan penelitian ini Untuk mengetahui potensi sektor-sektor ekonomi pada setiap Kecamatan di Kabupaten Lombok Utara yang memenuhi tiga keriteri yaitu : sektor ekonomi yang merupakan sektor basis,sektor ekonomi yang memiliki keunggulan kompetitif atau daya saing ,sektor ekonomi yang maju dan tumbuh cepat dibandingkan sektor yang sama pada tingkat Kabupaten Lombok Utara.

Data yang digunakan adalah data PDRB dan pertumbuhan ekonomi pada setiap sektor ekonomi yang ada pada setiap kecamatan di Kabupaten Lombok utara. Alat analisis data digunakan analisis Location Quotien, Sheft Share dan Analisis Tipology Klassen. Keriteria yang digunakan untuk mengetahui sektor dan sub sektor ekonomi potensial adalah jika sektor dan sub sektor ekonomi mempunyai nilai LQ> 1, sektor ekonomi maju dan cepat tumbuh, sektor ekonomi berkembang cepat, serta mempunyai keunggulan komparatif.

 Hasil penelitian menunjukan bahwa sektor dan sub sektor ekonomi potensial untuk KecamatanGangga adalah sektor pertanian yang didukung oleh sub sektor peternakan dan hasil-hasilnya serta sub sektor kehutanan. Sektor ekonomi potensial selanjutnya adalah sektor penggalian, sub sektor perdagangan , sub sektor sewa bangunan serta sub sektor sosial kemasyarakatan, untuk Kecamatan Pemenang,adalah subsektor perkebunan dan perikanan, air bersih, Bangunan, Hotel  dan restoran, Pengangkutan dan Komunikasi, Keuangan & jasa perusahaan serta sektor Jasa-jasa, untuk Kecamatan Tanjung l adalah subsektor perkebunan , penggalian, Industri pengolahan, listrik & air bersih, Bangunan, Hotel, Pengangkutan dan Komunikasi, Keuangan & jasa perusahaan serta sektor Jasa-jasa baik jasa pemerintahan umummaupunjasa swasta, untuki Kecamatan Bayan adalah Sektor Pertanian, mencakup Sub sektorPerkebunan, Peternakan,Perikanan. Sektor bangunandan sub sektor tanaman bahan makanan dan sektor, UntukKecamatan Kayangan hanya dua sektor yaitu sektor Pertanian dan sektor Perdagangan, Hotel dan Restoran. Sektor Pertanian adalah Sub Sektor Peternakan. Sektor Perdagangan Hotel dan Restoran. Selanjutnya disarankan kepada pemerintah Kabupaten Lombok Utara dan pemerintah setiap Kecamatan dalam membuat kebijakan pembangunan hendaknya memprioritaskan sektor dan sub sektor ekonomi potensial dan pembangunan sektor industri hendaknya disesuaikan dengan potensi ekonomi masing-masing kecamatan agar tercapai percepatan pembanguna di daerah Kabupaten Lombok Utara.
Nanoparticle Formula Optimization of Juwet Seeds Extract (Syzygium cumini) using Simplex Lattice Design Method
Authors: Juliantoni Yohanes , Hajrin Wahida , Subaidah Windah Anugrah
Published: November 2020

Diabetes is a degenerative disease whose numbers continue to increase from year to year. Treatment with oral antidiabetic drugs can cause harmful side effects for patients. One of the plants that can be used for diabetes therapy is juwet (Syzygium cumini L.). Flavonoid compounds of juwet seed is easily oxidized and hydrolyzed in intestinal fluids with low absorption. This problem can be overcome by forming nanoparticle of juwet seed extract. The aims of this study was to obtain the formula for juwet seed nanoparticles. Nanoparticle of juwet seed extract made by ionic gelation method with chitosan and Na-TPP polymers which are varied. The formula optimization design in this study was determined using a simplex lattice design by 3 variations of materials based on the parameters %entrapment efficiency, %transmittant, particle size, polydisperse index, and zeta potential. The results showed that the yield of duwet seed extract was 7,44%. Juwet seed ethanolic extract contains 3.33 mg of quercetin per 1 g of extract. Based on the desirability value approach, the optimum formula was produced with an extract composition of 1.650 mL; chitosan 0.500 mL; and Na-TPP 0.010 mL can give optimal results with a desirability value of 0.772 which results in the criteria of 63.66% entrapment efficiency; 50.56% transmittant; 615,833nm particle size; 0.620 PDI; and zeta potential of +13.89 mV. Juwet seeds extract can be formulated into the form of nanoparticles. To get better parameters, it is advisable to optimize the mixing time and mixing speed in the ionic gelation method.
Self-Instrusction Sebagai Teknik Alternatif Meningkatkan Kepercayaan Diri (Overt-Covert) Siswa SMP
Authors: Susanti Romia Hari
Published: November 2020

Buruknya konsep diri pada remaja salah satunya dapat dilihat dari adanya ketidakpercayaan diri. Siswa yang percaya diri yakin atas kemampuan diri serta memiliki pengharapan yang realistis.Tujuan penelitian eksperimen ini adalah mengurangi pengharapan tidak realistis dengan menggunakan teknik instruksi diri yang dapat mengarahkan siswa untuk mengontrol perilaku dan pemikiran-pemikiran negatif yang menimbulkan rendahnya rasa percaya diri (overt-covert). Hasil analisis uji wilcoxon menunjukkan bahwa sig. (2-tailed) 0,042<0,05 yang dapat diartikan teknik self instruction dapat meningkatkan kepercayaan diri siswa SMP Muhammadiyah 4 Singosari dengan taraf signifikan 5%. Penggunaan teknik self instruction sebagai alternatif teknik untuk meningkatkan kepercayaan diri siswa dimulai dari prosedur rasional, bimbingan diri sendiri, overt eksternal guidance, overt self guidance, faded overt self guidance, covert self guidance, dan homework.
Metode Pengembangan Social Question Pada Anak Dalam Perspektif Pembimbing
Authors: Wijio Sarono
Published: November 2020

Kecerdasan sosial saat ini dipandang sebagai faktor penentu keberhasilan seorang anak dalam pendidikan. Tujuan dari penelitian ini adalah  menguraikan terkait kecerdasan sosial anak dan  metode untuk mengembangkan kecerdasan sosial anak. Jenis penelitian ini adalah deskriptif kualitatif yang secara langsung dilakukan pada obyek yang diteliti guna menghasilkan data-data yang diperlukan dan untuk menjawab rumusan masalah yaitu: bagaimana pemahaman pembimbing tentang kecerdasan sosial pada anak dan metode pembimbing dalam mengarahkan anak untuk mengembangkan kecerdasan sosial di TK Pembina I Putussibau. Pengumpulan data dilakukan dengan wawancara, observasi dan dokumentasi terhadap sumber data penelitian yang meliputi: guru pembimbing di TK Pembina I Putussibau, siswa, brosur dan kurikulum. Metode deskriptif kualitatif digunakan sebagai analisis data dengan cara data yang tersedia diolah selama penelitian selanjutnya secara sistematis diinterpretasikan ke dalam laporan. Diketahui hasil penelitian sebagai berikut: 1) Pemahaman pembimbing tentang kecerdasan sosial pada anak adalah bahwa  kecerdasan sosial merupakan kemampuan yang ditunjukkan anak saat berinteraksi dengan orang lain atau lingkungan sosial. 2) Metode yang digunakan pembimbing dalam mengembangkan kecerdasan sosial anak secara praktis adalah dengan bimbingan  individu dan kelompok, sedangkan secara teoritis pendekatan yang digunakan pembimbing adalah pendekatan kognitif dan social learning dari  Albert Bandura.
Mereduksi Stres Dalam Belajar Dengan Menggunakan Strategi Relaksasi
Authors: Sari Ita Dian Arvita
Published: November 2020

Di masa pandemi Covid-19 ini di mana segala sesuatu harus dilakukan dari rumah, termasuk belajar. Banyak permasalahan yang dihadapi siswa selama Pembelajaran Jarak Jauh (PJJ), yang akhirnya membuat siswa mengalami stres dalam belajar. Mulai dari siswa merasa jenuh belajar di rumah, sulit berkonsentrasi, cemas, gelisah ketika mendapat tugas dari guru, sehingga menimbulkan pusing/sakit kepala dan nafsu makan berkurang. Permasalahan di atas jika tidak segera diselesaikan maka akan berdampak pada nilai hasil belajar siswa. Salah satu strategi untuk mengatasinya yaitu dengan strategi relaksasi. Tujuan dari penelitian ini adalah untuk mengetahui teknik relaksasi dapat mereduksi stres dalam siswa kelas XI MIPA 1 SMA Negeri 1 Mantup Lamongan ajaran 2020/2021. Penelitian ini merupakan penelitian single subject. Penelitian ini berlangsung selama 2 siklus yaitu siklus I dan siklus II. Teknik pengumpulan data menggunakan wawancara, observasi, dan angket skala pengukuran. Metode analisis data menggunakan analisis data kualitatif dan kuantitatif. Kondisi awal skor stres mencapai 87,5, siklus I 75 sedangkan siklus II 47,5. Dari hasil analisis dapat disimpulkan bahwa ada perbedaan tingkat stres belajar siswa sebelum dan sesudah tindakan. Dengan demikian dapat disimpulkan bahwa strategi relaksasi dapat mereduksi stres dalam belajar siswa kelas XI MIPA 1 SMA Negeri 1 Mantup tahun ajaran 2020/2021.
Inovasi Produk, Kreatifitas Iklan Dan Brand Trust Mendorong Keputusan Pembelian
Authors: Santoso Rudi , Erstiawan Martinus Sony , Kusworo Angen Yudho
Published: November 2020

This research was conducted to reveal consumer behavior in terms of smartphone purchase decisions. The study tries to reveal consumer behavior in terms of deciding on product purchases, especially OPPO brand smartphones. The level of brand trust, innovation, ad creativity, and ad effectiveness are thought to influence consumer decisions in purchasing OPPO brand smartphones. The results showed that Product Innovation (X1), Ad Creativity (X2) and Ad Effectiveness (X3) had a significant effect with each value of β being 0.091; 0.589; and 0.580. Meanwhile Brand Trust (X4) has a negative effect on purchasing decisions. R2 value indicates 0.673, which means that the four variables simultaneously influence 67.3% of the purchasing decision (Y).
Market Generic Strategy pada Usaha Warkop Angkringan Berbasis Internet (WiFi) di Kab Mojokerto
Authors: M. Syamsul Hidayat  , Kasnowo  , Tatas Ridho Nugroho
Published: November 2020

The purpose of this research is to measure the Market Generic Strategy that is used by the owner of the internet (wifi) coffee shop / UMKM in Mojokerto Regency to be able to compete, be sustainable and achieve goals and get maximum profit. This research is an exploratory research that uses a qualitative approach in the form of a Focus Group Discussion. The sample consisted of 25 people, who were taken based on certain criteria. The technique of collecting data is by conducting open-ended interviews with the hope of obtaining complete information from these respondents. Data analysis using descriptive analysis method. The results showed that the Internet-based Market Generic Strategy of Warkop Angkringan (wifi) is a product differentiation strategy, service differentiation, personnel differentiation and focus strategy. Meanwhile, the way to retain customers is the availability of fast and friendly service, a variety of drinks and food, comfortable seating and room facilities as well as good cleanliness and layout.
Primary African American Endothelial Cells Exhibit Endothelial Dysfunction with an Exacerbated Inflammatory Profile and Blunted MMP-2 Activity
Authors: Cook Marc D. , Ling Chenyi , Grimm Heather , Adeyemo Adelola , Aldokhayyil Maitha , Heffernan Kevin , Fernhall Bo , Brown Michael
Published: November 2020

Endothelial dysfunction is associated with the racial health disparity in vascular dysfunction in African Americans (AAs). Matrix Metalloproteinase (MMP)-2 is constitutively expressed in endothelial cells (EC) and is a biomarker that has been associated with hypertension, as its properties are involved in pathologic oxidative stress and pro-inflammation that may affect vascular homeostasis.Herein, we report significant inverse relationships between MMP-2, stroke volume, carotid and aortic systolic pressures in a small cohort of young AA men. In the current study, we postulated that basal activation in AA Endothelial Cells (EC) may include different responses in MMP-2 activity, compared to Caucasian (CA). We evaluated gene and protein expression and activity of MMP-2, and related peptides, in multiple different primary Human Umbilical Vein Endothelial Cells (HUVEC) isolated from four different AA and CA donors. Compared to CA, AA HUVEC exhibited greater basal MMP-2, MMP-14, Tissue inhibitor of metalloproteinase-2, Vascular cell adhesion molecule-1, Intracellular adhesion molecule-1, and Interleukin (IL)-1βgene expression and greater endothelin-1 secretion (p< 0.05). Interestingly, basal MMP-2 protein expression was greater while relative secreted MMP-2 activity was lower (p= 0.041). Inflammatory stimuli (tumor necrosis factor-alpha) exacerbated relative MMP-2 activity in AA HUVEC (p= 0.007). Thesein vitrodata offer insights into a potential mechanism involving primary endothelial cell inflammatory mediated MMP-2 activities that may contribute to poorer vascular outcomes. Further studies are necessary to investigate endothelial intracellular transcriptional, translational, and activity regulation of MMP-2.
Spatial Distribution of Resources and Poverty Incidence in Ghana
Authors: Bathuure Isaac Akpemah , Brobbey Lens Opoku , Bawa Kingsley
Published: November 2020

This paper investigates the spatial distribution of resources, production activities and poverty in Ghana. The study found that the presence of natural resources in an area over a period of time greatly influences industrial activities in that locality. Moreover, given that firms or manufacturing industries will usually site their business ventures close to the sources of resource attraction, the processes of production including value addition, packaging, and refinery largely becomes vibrant in resource rich areas than less-resource zones. In Ghana, there seems to be an uneven distribution of natural resources across the administrative regions and ecological zones. This kind of distribution has resulted in the creation of additional jobs in areas endowed with natural resources. Data for the studies was obtain from Ghana statistical service

Spatial distribution of natural resources positively influences most important production activities in the discovered areas. A boom in production activities within an areas certainly reflect on the poverty incidence of the people since it creates both direct and indirect employment opportunities in that area. The paper suggests diversification of the economy, equitable allocation of resources to deprived areas to ensures comprehensive development and poverty alleviation in all aspects of life of the ordinary Ghanaian .Government needs to as well put in the needed measures to ensure people gets direct benefits from resources exploited in their communities as most of these exploitive activities pose negative externalities to the people.
Perbedaan antara Metode Pembelajaran Satu Arah dan Role-Play pada Program ETLS (Emergency Trauma Life Support ) dan CSR (Clinical Skill Refreshment) terhadap Nilai Obstetri Ginekologi pada Mahasiswa FK UMM
Authors: Andriana Kusuma
Published: November 2020

Keterampilan klinis merupakan satu dari 7 area kompetensi pada Standar Kompetensi Dokter Indonesia (SKDI). Model pembelajarannya bisa beragam salah satunya adalah bermain peran (role-play). FK UMM sudah melakukan perubahan metode pembelajaran keterampilan klinik dari satu arah ke metode role-play di program ETLS (Emergency Trauma Life Support ) dan CSR (Clinical Skill Refreshment), namun belum pernah dilakukan evaluasi dampaknya. Untuk mengetahui perbedaan antara metode pembelajaran satu arah dan role-play  di program ETLS dan CSR terhadap nilai obstetri ginekologi pada  mahasiswa FKUMM. Penelitian observasional analitik dengan cara iris silang (cross sectional) terhadap nilai ETLS – CSR gelombang 14 dan 15 (metode satu arah) dan gelombang 20  tahap 1 dan 2 (metode role-play  ) dan nilai kepaniteraan klinik obstetrik dan ginekologi dari mahasiswa yang telah mengikuti ETLS-CSR gelombang 14, 15 dan 20 tahap 1 serta 20 tahap  2. Diperoleh nilai rerata, maksimal dan minimal OSCE ETLS-CSR dan kepaniteraan klinik obstetri ginekologi metode role-play lebih tinggi daripada metode satu arah. Untuk melihat perbedaan metode satu arah dan role-play dilakukan uji Mann Whitney pada nilai ETLS dan CSR station obstetri dan ginekologi dengan  α = 0,000 (< 0,005),  dilakukan independent sample T test  pada nilai kepaniteraan  obstetri dan ginekologi dan didapatkan nilai  α = 0,000 (< 0,005) dan  dilakukan uji Wilcoxon Signed Ranks untuk melihat pengaruh pola pembelajaran  ETLS-CSR terhadap nilai kepaniteraan klinik obstetri ginekologi dan diperoleh nilai  α = 0,000 (< 0,005). Terdapat perbedaan bermakna antara metode pembelajaran satu arah dan role-play    di program ETLS (Emergency Trauma Life Support ) dan CSR (Clinical Skill Refreshment)  terhadap nilai obstetri ginekologi pada mahasiswa FK UMM
EFEK PEMBERIAN AIR KELAPA DAN AIR MINERAL TERHADAP KEBUGARAN JASMANI
Authors: Narindra Naufal Yusuf , Basuki Sri Wahyu , Risanti Erika Diana , Hernawan Budi
Published: November 2020

Peningkatan kebugaran jasmani dapat membantu dalam pencegahan penyakit. Terdapat korelasi yang signifikan antara tingkat kebugaran fisik dan angka kesakitan serta kematian yang disebabkan oleh penyakit kronis. Aktivitas fisik yang menyebabkan denyut nadi maksimal tercapai dapat membahayakan. Denyut nadi meningkat dapat dikarenakan oleh kurangnya cairan tubuh saat beraktivitas. Air kelapa merupakan salah satu contoh cairan yang mengandung bahan elektrolit yang baik bagi tubuh. Kandungan mineral dan sifat isotonis menjadikan air kelapa itu potensial dikonsumsi sebagai minuman olahraga. Penelitian bertujuan untuk mengetahui perbedaan indeks kebugaran jasmani pada pemberian air mineral dibandingkan dengan air kelapa sebelum aktivitas fisik. Metode penelitian menggunakan quasi experiment dengan rancangan pretest-posttest non equivalent control group design. Sampel sejumlah 20 mahasiswa laki-laki yang tidak rutin berolahraga dilakukan pengambilan data indeks kebugaran jasmani pada pemberian air kelapa serta air mineral. Hasil penelitian ini dengan uji t-independent  bernilai p>0,05. Simpulan tidak terdapat perbedaan yang signifikan antara indeks kebugaran jasmani pada pemberian air kelapa dan air mineral.
EFEKTIVITAS PEMBERIAN EKSTRAK DAUN YAKON “SMALANTHUS SONCHIFOLIUS” SEBAGAI TERAPI ANTIHIPERGLIKEMIA PADA MENCIT (MUS MUSCULUS) YANG DIINDUKSI STREPTOZOTOCIN
Authors: Triastuti Nenny , Irawati Detty Nur , Levani Yelvi , Prastya Aldo Dwi
Published: November 2020

Abstract Diabetes mellitus is an endocrine metabolite disorder characterized by hyperglycemia. This disorder is caused by demage to pancreatic beta cells or insulin resistance. According to WHO, an estimated 300 million people wordwide suffer from diabetes mellitus by 2025. The use medical drug must of course consider side effects including hypoglycemia, gastrointestinal disorders and impaired kidney function. Smalanthus sonchifolius is known to have anti-inflamatory, antioxidant and antidiabetic effects. Flavonoids as antioxidant and antidiabetic effects through several channels such as reducing apoptosis of beta pancreatic cells, promoting insulin secretion, glucose regulation on hepatocytes, reducing insulin resistance, reducing inflammation and oxidative stress on skeletal muscule cells and adipose tissue, and increasing glucose uptake in skeletal cells, This research uses a true experimental approach using the “Randomized pre and post test control group designI”. The population in this study were 28 male mice which would be divided into 4 groups, each group consisting of 7 individuals. 1 group as a control, and 3 treatment group with the administration of yakon extract each dose 200mg/KgBB, 300mg/KgBB, and 500mg/KgBB for 7 days. Of the four groups after streptozotocin induction, the highest average glucose value was 220,71mg/dl at K and the smallest value at P3 was 208,29mg/dl. While changes in the average glucose value after administration of the extract decreased, the largest value reached 50 at P3 and the smallest value at P1 which was only 36,71. Whereas in K it increased by 0,43 Key word: Diabetes Mellitus, Smalanthus sonchifolius, glucose
Leiomioma uterino associado a CA125 > 2000 U/mL
Authors:   Universidade Federal da Bahia - Faculdade de Medicina – Salvador, BA, Brasil, Miranda Diego Lopes Paim , Dórea Carolina Matos , Bastos Anderson Rodrigues Dourado , Neves Adson Roberto Santos , Landeiro Luciana Castro Garcia ,   Hospital da Mulher - Salvador, Bahia, Brasil,   Grupo Oncoclínicas - Núcleo de Oncologia da Bahia – Salvador, BA, Brasil
Published: November 2020

Níveis elevados de CA125 têm sido associados a vários tipos de câncer e outras doenças benignas, tais como endometriose e leiomioma uterino. No entanto, pacientes com endometriose normalmente não apresentam níveis >100 U/mL e um aumento significativo raramente é observado no cenário do leiomioma uterino. Uma mulher de 47 anos, nulípara, com leiomioma, apresentou-se ao nosso Departamento de Oncologia devido ao aumento de volume abdominal e elevação de CA125 (valor máximo: 2002 U/mL). A ressonância magnética da pelve revelou miométrio heterogêneo com múltiplos nódulos (aspecto sugestivo de leiomiomatose uterina) e a tomografia por emissão de pósitrons não demonstrou aumento no metabolismo de FDG. A paciente foi submetida a histerectomia total, salpingectomia bilateral e a biópsia em cunha de ambos os ovários e o exame histopatológico confirmou o diagnóstico de endometriose e de leiomioma uterino. O período pós-operatório transcorreu sem intercorrências e o nível sérico de CA125 voltou à normalidade após a cirurgia.
The effect of soy flour and carob flour addition on the physicochemical, quality, and sensory properties of pasta formulations
Authors: DÜLGER ALTINER Dilek , HALLAÇ Şeyma
Published: November 2020

In the present study, soy flour (SF) and carob flour (CF) were used as a substitute for wheat flour (WF) in 6 different pasta formulations. The effect of SF and CF on the quality properties of the enriched pasta formulations was investigated. With the increase in SF and CF, ash, protein, dietary fiber content of the pasta increased whereas moisture, fat, and carbohydrate contents decreased. With the increase in CF, a significant decrease was observed in the L* (brightness) value and an increase in b* value with an addition of SF. The addition of SF and CF reduced the amount of substance passed to the water, improving the quality of the pasta. According to the results of sensory analysis, the highest values in terms of the overall evaluation were determined in the D (80 WF: 0 SF: 20 CF) and the E (80 WF: 20 SF: 0 CF) samples, and it was determined that up to 20% SF and CF can be recommended. According to the study results, it was thought that SF and CF can be used as functional food additives in different food formulations to improve the functional and nutritional properties of food products.
Perbedaan Peningkatan Kadar Saturasi Oksigen Setelah Terapi Oksigen Binasal Kanul dengan Sungkup Muka Sederhana terhadap Pasien Pasca CABG
Authors: Susanto Tandang , Warongan Anwar , Rayasari Fitrian
Published: November 2020

Penyakitajantung koronerabisa diaatasi denganatindakan operasi Coronay Artery bypass Grafting (CABG). SetelahÂ  ekstubasi, untuk mencegahÂ  hipoksemiaÂ  segera diterapi oksigen sesuai dengan kondisi pasien terutama pada 24 jam pertama. Penelitian iniÂ  untuk mengetahui efektifitas pemberian terapi oksigen binasal kanul dengan sungkup muka sederhana. Desainapenelitianaquasi eksperimen preadan postatwo group dengan populasi pasien CABGadi ICU bedahaRumah Sakit Jantungadan PembuluhaDarah HarapanaKita. Terdiri dari 32 responden dengan teknik simple random sampling, 16 responden dilakukan intervensi terapi oksigen binasal kanul dan 16 responden dengan sungkup muka sederhana. Hasil uji Mann Whitney kenaikan rata-rata saturasi oksigen setelah intervensi binasal kanul dengan sungkup muka sederhana diperoleh pavalueÂ  0,591> alpha (0,05).