bluuebunny/crossref_metadata_2025 huggingface dataset:
How Capital Intervention Impacts Rural Sustainable Development: A Case Study of Two Suburban Villages near Wuhan
Authors: Tang Yongwei , Zhou Yong , Ci Hui , Liu Helin , Luo Mei , Xu Ying , Zhang Maomao
Published: January 2025

Capital plays a crucial role in driving rural sustainable development. Some rural areas have achieved revitalization through capital intervention, while others have experienced failure. It is possible that the purposes of capital intervention initiated by different parties (such as government, enterprises, and individual investors) in rural areas differ, which leads to the divergence of development routes and effectiveness. Yet, the questions of why and how this phenomenon occurs have not been well studied. Based on observation and an in-depth interview conducted in two suburban villages near Wuhan, we have established an analytical framework with which to compare the route and effectiveness of rural developments driven by capital intervention. The results are as follows: (1) The sources of capital and the embedded purposes determine the modes of rural resource reconfiguration and the arrangement of the relevant industrial sectors. The answer to the question of how to allocate capital gains among different interest groups engaged in rural development determines whether a community of shared interests with respect to sustainable rural development can be established and operate effectively. (2) As the profit-making process differs among capital originating from different sources, it is necessary to evaluate this process such that the pursuit of capital gains and its influence upon rural sustainable development can be clarified and coordinated. (3) Throughout the capital intervention process, villagers’ participation is crucial as it is the prerequisite for the establishment of a mutually beneficial win–win relationship between external capital investors and local villagers. This comparative study of the two villages can provide insights into policy formulation for the purpose of rural revitalization in China and other countries in the Global South undergoing rapid urbanization.
Significant Calcification of an Entire Aortic Tree with Renal Artery Subocclusion: Acute Kidney Injury, Ischemic Kidney Disease, and the Tissue Viability Question—A Case Report
Authors: Baralić Marko , Gajić Selena , Kezić Aleksandra , Bontić Ana , Pavlović Jelena , Brković Voin , Karadžić Ristanović Vidna , Bjelić Danka , Životić Maja , Radojević-Škodrić Sanja , Antonić Želimir , Ilijevski Nenad , Radović Milan
Published: January 2025

Background: Undiagnosed and untreated atherosclerotic renal artery stenosis (ARAS) can result in end-stage kidney disease (ESKD). To obtain an accurate diagnosis, it is crucial to recognize the symptoms and signs suggesting renal artery stenosis (RAS) and perform appropriate diagnostic and treatment procedures afterward. Case Presentation: We present a case of a 60-year-old female patient with hypertensive crisis, acute heart failure (HF), and pulmonary edema as the initial signs of acute kidney injury (AKI) caused by right RAS and left renal artery occlusion in the presence of severe aortic atherosclerosis revealed on computed tomography angiography (CTA) of the abdomen. The patient’s renal function recovered completely following percutaneous transluminal angioplasty (PTA) with stent implantation in the right renal artery at the site of subocclusion. Conclusions: Even in patients with concomitant disorders like type-2 diabetes mellitus (T2DM), hypertension (HTN), or HF, the dilatation of significantly narrowed renal arteries due to severe calcifications can result in complete renal function recovery.
Focus on Exercise Physiology and Sports Performance
Authors: Yu Laikang
Published: January 2025

Exercise physiology is a crucial scientific discipline that explores the complex manner in which physical activity influences the physiological responses and adaptations of the human body [...]
Pre- and Post-Procedural Considerations and Thread Types for Thread Lifting
Authors: Hong Gi-Woong , Wan Jovian , Yoon Song-Eun , Wong Sky , Yi Kyu-Ho
Published: January 2025

Facial thread lifting has emerged as a minimally invasive alternative to traditional face-lifting procedures, with particular emphasis on U-shaped and I-shaped barbed threads. This review analyzes the anatomical considerations, procedural techniques, and clinical outcomes of different thread types for facial rejuvenation. The study examines the mechanical principles and lifting mechanisms of U-shaped “suspension type” threads versus I-shaped threads, highlighting their distinct characteristics and applications. The results indicate that U-shaped threads provide strong lifting effects, with success rates reported at 85–90% in achieving visible tissue elevation when anchored in the temporal area. However, these threads carry higher risks of complications, including bleeding (15–20%), dimpling (12–18%), and tissue damage at exit points (5–10%). In contrast, I-shaped threads demonstrate advantages in minimizing tissue trauma and patient discomfort, with complication rates below 5%, though they may provide less dramatic lifting effects. The study concludes that optimal outcomes are achieved through careful patient selection and customized combination approaches rather than reliance on a single thread type. Future directions point toward the development of hybrid techniques that combine the strengths of both thread types to maximize efficacy while minimizing complications.
Human Defence Factors in Different Gestational Week Placenta: A Pilot Study
Authors: Kamergrauzis Andris , Pilmane Mara , Junga Anna
Published: January 2025

Background: Numerous studies have shown the presence of multiple defence factors in placental tissue, although their role is partially understood; therefore, the aim of this study was to evaluate the expression of nuclear factor-kappa B (NF-κB); human beta-defensin 2, 3, and 4 (HBD-2,3,4); cathelicidine (LL-37); heat shock protein 60 (HSP60); and interleukin 10 (IL-10) in dissimilar gestational week placental tissue and display correlations between immunoreactive cells. Methods: A total of 15 human placental tissue samples were acquired from mothers with different gestational weeks: 28, 31, and 40. Routine staining and immunohistochemistry for the samples were executed. The evaluation of data was performed with semi-quantitative methods, and, for statistical analysis, the Kruskal–Wallis test was used. Spearman’s rank correlation was used for calculating correlations. Results: NF-κB, HBD- 2,3,4, HSP60, and IL-10 expression were discovered in every examined placental tissue cell type. LL-37 expression was found only in Hofbauer cells. A rise in expression with higher gestational weeks was noted in LL-37-positive Hofbauer cells (p = 0.03), HBD-3-positive cytotrophoblasts (p = 0.007), endothelial cells (p = 0.024), extraembryonic mesodermal cells (p = 0.004), and HBD-4-positive endothelial cells (p = 0.001). Numerous statistically significant moderate and strong positive correlations between defence factors were discovered. Conclusions: The persistence of Hofbauer cell accumulations underlines the growing significance of placental macrophages in placental protection. The expression of positive defence factors and a rise in expression in tissue protection factors (HBD-3, LL-37, HBD-4) in higher gestational weeks may indicate these factors as the most significant protectors of the placenta in ontogenetic aspects. The high number of statistically significant positive and negative correlations between positive cells show a strong network to sustain distressed placental growth and therefore pregnancy.
The Low Friction Coefficient and High Wear Resistance UHMWPE: The Effect of Pores on Properties of Artificial Joint Materials
Authors: Yang Chunmin , Zhang Junhua , Yue Honglin , Kang Xueqin
Published: January 2025

Ultrahigh-molecular-weight-polyethylene (UHMWPE) is extensively applied to make bone and cartilage implants in the field of biomaterial application. UHMWPE matched with a metal or ceramic component withstands the long-term effect of cyclic stress, which induces UHMWPE serious wear, and affects the service life of the artificial joint. This investigation focuses on the influence of pores on the mechanical and tribological property of UHMWPE. The porosity, crystallinity, yield strength, tensile strength, hardness, compression yield strength, creep resistance, wettability, friction performance, and wear mechanism of solid and porous UHMWPE were evaluated and compared. The research results indicated that the pore had a remarkable influence on the mechanical, friction, and wear property of UHMWPE. The porosity of porous UHMWPE was 29.7% when 50 wt. % sodium chloride (NaCl) was added and the pore size was about 200 μm. The crystallinity, hardness, creep resistance, strength, and elongation decreased after NaCl was added and dissolved. However, the yield strength in the tensile and compression test was closer to that of the natural cartilage. The friction coefficient and wear loss of porous UHMWPE were higher than that of solid UHMWPE in dry conditions, but these values of porous UHMWPE were lower than that of solid UHMWPE in the calf serum lubrication condition. The main wear mechanism of porous and solid UHMWPE was abrasive. The lubricity of calf serum reduced wear surface scratches and furrows, especially for porous UHMWPE.
A Comparative Finite Element Analysis of Titanium, Autogenous Bone, and Polyetheretherketone (PEEK)-Based Solutions for Mandibular Reconstruction
Authors: Ghionea Ionut Gabriel , Tarba Cristian Ioan , Cristache Corina Marilena , Filipov Iulian , Beuran Irina Adriana
Published: January 2025

Mandibular reconstruction is essential for restoring both function and aesthetics after segmental resection due to tumoral pathology. This study aimed to conduct a comparative analysis of three reconstruction strategies for defects resulting from segmental mandibular resection, utilizing finite element analysis (FEA). Methods: A digital model of the mandible was created from CBCT data and optimized for FEA. Three reconstruction scenarios were simulated: fixation with a titanium plate, reconstruction with an autogenous fibular graft stabilized with the same titanium plate, and fixation with a customized PEEK plate. Various plate thicknesses were analyzed to determine the stress and deformation patterns under masticatory loads. Results: Titanium plates provided superior mechanical stability but showed stress concentrations near screw fixation points. The addition of autogenous bone grafts reduced stress on the plate and improved structural integrity. PEEK plates exhibited reduced stress shielding and better load distribution, but thinner designs were prone to deformation. Minimum recommended thicknesses of 1.2 mm for titanium plates and 1.8 mm for PEEK plates were identified by FEA. Conclusions: This study highlights the importance of material selection and patient-specific design in mandibular reconstruction. Autogenous bone grafts combined with titanium plates demonstrated the best biomechanical outcomes, while PEEK plates offer a promising alternative, particularly for patients where grafting is contraindicated.
Tribo-Electrochemical Mechanism of Material Removal Examined for Chemical Mechanical Planarization of Stainless-Steel Using Citrate Buffer as a Complexing Agent
Authors: Santefort David R. , Gamagedara Kassapa U. , Roy Dipankar
Published: January 2025

Chemical mechanical planarization (CMP) is a technique used to efficiently prepare defect-free, flat surfaces of stainless steel (SS) foils and sheets that are implemented in various modern devices. CMP uses (electro)chemical reactions to structurally weaken the surface layers of a workpiece for easy removal by low-pressure mechanical abrasion. Using a model CMP system of 316/316L stainless steel (SS) in an acidic (pH = 3.63) slurry with alumina abrasives, citrate buffer (CB), and H2O2, we examine the tribo-electrochemical mechanisms of SS CMP that dictate the designs of functionally efficient and cost-effective CMP slurries. The use of CB as a pH-controlled complexing agent prevents defect-causing dissolution of SS and eliminates the need for using separate (often toxic) corrosion inhibitors in the slurry. A material removal rate of 8.6 nm min−1 is obtained at a moderate down pressure of 0.014 MPa with a platen rotation speed of 95 RPM. Electrochemical techniques are strategically combined with mechanical abrasion of SS test samples to probe complex CMP mechanisms that are not readily accessible with electrochemical experiments alone. Corrosion-like reactions of salt-film formation at the SS surface act to enable the CMP process, where corrosion-induced wear plays a major role in material removal.
Materials Design and Structural Health Monitoring of Horizontal Axis Offshore Wind Turbines: A State-of-the-Art Review
Authors: Tong Yihui , Liu Weitao , Liu Xuanyi , Wang Peng , Sheng Zhe , Li Shengquan , Zhang Hao , Meng Yuwei , Zhu Ye , Lei Xubing , Lin Ying-Tien , Jiao Pengcheng
Published: January 2025

In recent decades, Offshore Wind Turbines (OWTs) have become crucial to the clean energy transition, yet they face significant safety challenges due to harsh marine conditions. Key issues include blade damage, material corrosion, and structural degradation, necessitating advanced materials and real-time monitoring systems for enhanced reliability. Carbon fiber has emerged as a preferred material for turbine blades due to its strength-to-weight ratio, although its high cost remains a barrier. Structural Health Monitoring Systems (SHMS) play a vital role in detecting potential faults through real-time data on structural responses and environmental conditions. Effective monitoring approaches include vibration analysis and acoustic emission detection, which facilitate early identification of anomalies. Additionally, robust data transmission technologies are essential for SHMS effectiveness. This paper reviews material design strategies, data acquisition methods, and safety assessment techniques for OWTs, addressing current challenges and future directions in the field.
Stress Distributions and Luminescent Responses of Mechanoluminescent Cylinders with Various Sizes and Loading Paths
Authors: Sun Chang-Ying , Liu Wei , Shi Xin , Rao Guang-Hui , Zhao Jing-Tai
Published: January 2025

Mechanoluminescent (ML) materials emit light by trapping and releasing charge carriers under mechanical stress. However, previous studies do not fully reveal the relationship between emitting light intensity and mechanical stress, thereby affecting the accuracy of stress measurement. This study addresses this gap by systematically investigating ML cylinders with various sizes and loading paths using theoretical analysis and simulations, focusing on the maximum contact stress, equivalent stress distribution, and the relationship between the strain energy density and light intensity at the point of maximum contact stress. In combination with experiments, the mechanical behavior and optical responses of ML cylinders under normal compressive forces reveal that the luminescence intensity is closely related to cylinder size and loading path, effectively reflecting stress distributions in objects of different sizes under complex stress conditions. Particularly, within the elastic range and under ideal conditions where lateral stress is ignored, the maximum contact stress is nearly equal to the equivalent stress. The equivalent stress is linearly related to the light intensity, while the strain energy density at the maximum contact stress point is proportional to the square root of the light intensity. This work promotes the application of ML materials in structural health monitoring and stress visualization.
Investigation of Factors Influencing Solenoid Valve Speed Response Characteristics of the Common Rail Injector
Authors: Bai Yun , Du Chengda , Sun Qiang , Bu Shi , Wang Ao
Published: January 2025

The dynamic injection characteristics of high-pressure common rail fuel injection systems are determined by the speed response performance of the solenoid valve. A simulation model has been established for investigating the influence mechanism and change law of characteristic parameters on speed response characteristics of the solenoid valve. The speed response characteristics of the solenoid valve, including the average opening speed, the average closing speed, the maximum opening speed, and the maximum closing speed, caused by the changes of characteristic parameters such as pre-tightening force of the solenoid valve spring, mass of the solenoid valve moving parts, diameter of the outflow orifice, diameter of the inflow orifice, diameter of the control piston, and pressure in the common rail, have been studied. The correlation analysis of the influence factors is carried out by using the experimental design method based on the response surface model, and the correlation coefficients between each factor and the speed response characteristics of the solenoid valve are obtained. The results show that both single factors and interaction factors of the parameters are correlated with the speed response characteristics of the solenoid valve. The results of this paper can provide a theoretical reference for the design and optimization of the high-pressure common rail injector.
Numerical Investigation and Experimental Verification of Vibration Behavior for a Beam with Cantilever-Hertzian Contact Boundary Conditions
Authors: Zhang Yinnan , Zhang Chao , Meng Yuan , Ren Wanbin
Published: January 2025

The simple spring structure, with detachable electrical contacts, is a very suitable solution for many applications, such as electromechanical relays and connectors. However, they are prone to exhibit instantaneous interruption faults under mechanical vibration environments. In this paper, the governing equations of the modal analysis of a beam with cantilever-Hertzian contact boundary conditions are presented. Then, the time domain analysis method and frequency domain analysis method for solving the forced vibration response are described explicitly. Next, the effect of the axial force on the modal frequency of a detailed model sourced from the practical relay is investigated by using commercial ANSYS Workbench 2021R1 software. Afterward, the harmonic response of the beam is numerically solved individually by using the transient analysis model and the harmonic analysis model in ANSYS Workbench 2021R1 software. Then, the influences of the damping coefficient and excited frequency on the contact force response are investigated. The experimental results of transient displacement and contact resistance of the beam structure agree well with the simulation outcomes. It is proven that there is a linear relationship between the stiffness coefficient and the mass coefficient, which are used for characterizing the damping of the structures in the time domain method and frequency domain methods.
Ricci–Bourguignon Almost Solitons with Vertical Torse-Forming Potential on Almost Contact Complex Riemannian Manifolds
Authors: Manev Mancho
Published: January 2025

Almost contact complex Riemannian manifolds, also known as almost contact B-metric manifolds, are equipped with Ricci–Bourguignon-like almost solitons. These almost solitons are a generalization of the known Ricci–Bourguignon almost solitons, in which, in addition to the main metric, the associated metric of the manifold is also involved. In the present paper, the soliton potential is specialized to be pointwise collinear with the Reeb vector field of the manifold structure, as well as torse-forming with respect to the two Levi-Civita connections of the pair of B-metrics. The forms of the Ricci tensor and the scalar curvatures generated by the pair of B-metrics on the studied manifolds with the additional structures have been found. In the three-dimensional case, an explicit example is constructed and some of the properties obtained in the theoretical part are illustrated.
A New Closed-Loop Control Paradigm Based on Process Moments
Authors: Vrančić Damir , Bisták Pavol , Huba Mikuláš , Moura Oliveira Paulo
Published: January 2025

The paper presents a new control concept based on the process moment instead of the process states or the process output signal. The control scheme is based on separate control of reference tracking and disturbance rejection. The tracking control is achieved by additionally feeding the input of the process model by the scaled output signal of the process model. The advantage of such feedback is that the final state of the process output can be analytically calculated and used for control instead of the actual process output value. The disturbance rejection, including model imperfections, is controlled by feeding back the filtered difference between the process output and the model output to the process input. The performance of tracking and disturbance rejection is simply controlled by two user-defined gains. Several examples have shown that the new control method provides very good and stable tracking and disturbance rejection performance.
Quantifying Uncertainty of Insurance Claims Based on Expert Judgments
Authors: Handoko Budhi , Franty Yeny Krista , Indrayatna Fajar
Published: January 2025

In Bayesian statistics, prior specification has an important role in determining the quality of posterior estimates. We use expert judgments to quantify uncertain quantities and produce appropriate prior distribution. The aim of this study was to quantify the uncertainty of life insurance claims, especially on the policy owner’s age, as it is the main factor determining the insurance premium. A one-day workshop was conducted to elicit expert judgments from those who have experience in accepting claims. Four experts from different insurance companies were involved in the workshop. The elicitation protocol used in this study was The Sheffield Elicitation Framework (SHELF), which produces four different statistical distributions for each expert. A linear pooling method was used to aggregate the distributions to obtain the consensus distribution among experts. The consensus distribution suggested that the majority of policy owners will make a claim at the age of 54 years old.
Identification of Biomarkers of Arrhythmogenic Cardiomyopathy (ACM) by Plasma Proteomics
Authors: Zarrouk Sinda , Ben-Miled Houda , Rahali Nadia , Finsterer Josef , Ouarda Fatma
Published: January 2025

Background and Objectives: The pathophysiology of arrhythmogenic cardiomyopathy (ACM), previously known as arrhythmogenic right ventricular cardiomyopathy (ARVC), and its specific biological features remain poorly understood. High-throughput plasma proteomic profiling, a powerful tool for gaining insights into disease pathophysiology at the systems biology level, has not been used to study ACM. This study aimed at characterizing plasmatic protein changes in patients with ACM, which were compared with those of healthy controls, and at exploring the potential role of the identified proteins as biomarkers for diagnosis and monitoring. Materials and Methods: Blood samples were collected from six ACM patients, four patients with other cardiomyopathies, and two healthy controls. Plasma was processed to remove high-abundance proteins and analyzed by two-dimensional gel electrophoresis. Differential protein expressions were assessed using PDQuest software, Bio-Rad US version 8.0.1. Results: The analysis revealed several proteins with altered expressions between ACM patients and controls, including plakophilin-2, junctional plakoglobin, desmoplakin, desmin, transmembrane protein 43, and lamin A/C. Conclusions: The plasma proteomic profiling of ACM suggests that ACM is a distinct disease entity characterized by a unique dysregulation of desmosomal proteins. The identification of plasma biomarkers associated with ACM underscores their potential to improve diagnostic accuracy and facilitate early intervention strategies. Further exploration of mutations in desmosomal proteins and their phosphorylation states may provide deeper insights into the pathophysiology of ACM.
Oxidative Stress and Risk of Dementia in Older Patients with Depression: A Longitudinal Cohort Study Using Plasma Biomarkers
Authors: Jang Yoo-Jin , Kim Min-Ji , Lee Su-Jin , Lim Shinn-Won , Kim Doh-Kwan
Published: January 2025

Background and Objectives: While depression is associated with an increased risk of Alzheimer’s dementia (AD), traditional AD-related biomarkers, such as amyloid-beta, have shown limited predictive value for late-life depression. Oxidative stress has emerged as a potential indicator given its shared role in both depression and dementia. This study investigated the longitudinal relationship between oxidative stress biomarkers and risk of dementia in patients with depression. Materials and Methods: A longitudinal cohort of 146 older patients with major depressive disorder was analyzed. Biomarkers, such as nitrotyrosine, protein carbonyl, F2-isoprostanes, malondialdehyde, 4-hydroxynonenal, and 8-hydroxy-2′-deoxyguanosine, were collected at baseline and measured using an enzyme-linked immunosorbent assay. AD conversion was determined using comprehensive neuropsychological assessment. Cox proportional hazards models were used to evaluate the association between oxidative stress biomarkers and AD conversion after adjusting for confounders. The log-rank test, using the minimum p-value approach, was applied to determine the optimal cut-off value for significantly associated biomarkers of AD-free survival rates. Results: During the follow-up period ranging from 1.00 to 18.53 years, 41 (28.08%) patients converted to AD. Nitrotyrosine showed a significant association with increased risk of AD (adjusted hazard ratio [HR], 1.01; 95% confidence interval [CI], 1.00–1.01; p = 0.0045). For clinical applicability, patients with plasma nitrotyrosine levels ≥170 nM as the cut-off value had a 5.14-fold increased risk of AD (adjusted HR, 5.14; 95% CI, 2.02–13.07; p = 0.0006). Other biomarkers, such as protein carbonyl, F2-isoprostanes, malondialdehyde, 4-hydroxynonenal, and 8-hydroxy-2′-deoxyguanosine, were not significantly associated with AD conversion. Conclusions: Nitrotyrosine, a biomarker that reflects nitrosative damage, emerged as a significant predictor of dementia risk in older patients with depression, highlighting its potential as an early biomarker of dementia. Further validation of these results is required using a larger sample size.
Is Artificial Intelligence the Next Co-Pilot for Primary Care in Diagnosing and Recommending Treatments for Depression?
Authors: Levkovich Inbar
Published: January 2025

Depression poses significant challenges to global healthcare systems and impacts the quality of life of individuals and their family members. Recent advancements in artificial intelligence (AI) have had a transformative impact on the diagnosis and treatment of depression. These innovations have the potential to significantly enhance clinical decision-making processes and improve patient outcomes in healthcare settings. AI-powered tools can analyze extensive patient data—including medical records, genetic information, and behavioral patterns—to identify early warning signs of depression, thereby enhancing diagnostic accuracy. By recognizing subtle indicators that traditional assessments may overlook, these tools enable healthcare providers to make timely and precise diagnostic decisions that are crucial in preventing the onset or escalation of depressive episodes. In terms of treatment, AI algorithms can assist in personalizing therapeutic interventions by predicting the effectiveness of various approaches for individual patients based on their unique characteristics and medical history. This includes recommending tailored treatment plans that consider the patient’s specific symptoms. Such personalized strategies aim to optimize therapeutic outcomes and improve the overall efficiency of healthcare. This theoretical review uniquely synthesizes current evidence on AI applications in primary care depression management, offering a comprehensive analysis of both diagnostic and treatment personalization capabilities. Alongside these advancements, we also address the conflicting findings in the field and the presence of biases that necessitate important limitations.
Recovery of Iodine in the Gaseous Phase Using the Silicone Hollow Fiber Membrane Module
Authors: Yamabe Yoshio , Takahashi Naotake , Sawai Jun , Minami Tamotsu , Kikuchi Mikio , Ishii Toshimitsu
Published: January 2025

Iodine, being an important resource, must be recovered and reused. Iodine is not only attracted to the hydrophobic silicone membrane but also easily vaporized. In this study, we explored the use of five types of silicone hollow fiber membrane modules (SFMMs) for separating iodine in the gaseous phase. In the SFMM, iodine gas and the recovery solution (sodium sulfite and sodium carbonate at a concentration of 10 mM each) were flowed outside and inside the silicone hollow fiber, respectively, in a co-current-flow manner. At an iodine gas flow rate of 0.2 L/min (8.4 × 10−3 mmol-I2/L), the capture efficiency of iodine into the SFMM was approximately 100% for all five SFMMs. With increasing feed gas flow rates, the capture efficiency of iodine decreased, reducing to approximately 50% at 0.8 L/min. However, the recovery efficiency of iodine in the recovery solution was 60–30% at 0.2–0.8 L/min. This decrease in capture efficiency with increasing flow rates was because iodine could not spread and diffuse successfully in the SFMM, resulting in a low recovery efficiency of iodine. Thus, we next improved the structure of the SFMM by placing a perforated pipe in the center of the module. The perforated pipe effectively directs the iodine feed gas from the holes in the pipe to the hollow fiber membrane bundle wrapped around the pipe. With the improved SFMM, the capture efficiency markedly increased to approximately 100% in the range of the flow rates tested in our experiments. The recovery efficiency also increased to ≥70%. These data illustrate the potential application of the improved SFMM for recovering iodine in the gaseous phase.
Phase-Field Modelling of Bimodal Dendritic Solidification During Al Alloy Die Casting
Authors: Torfeh Maryam , Niu Zhichao , Assadi Hamid
Published: January 2025

Tracking the microstructural evolution during high-pressure die casting of Al-Si alloys is challenging due to the rapid solidification, varying thermal conditions, and severe turbulence. The process involves a transition from slower cooling in the shot sleeve to rapid cooling in the die cavity, resulting in a bimodal dendritic microstructure and nucleation of new finer dendrite arms on fragmented externally solidified crystals. In this study, a two-dimensional phase-field model was employed to investigate the solidification behaviour of a hypoeutectic Al-7% Si alloy during high-pressure die casting. The model is based on thermodynamic formulations that account for temperature changes due to phase transformation heat, thermal boundary conditions, and solute diffusion in both liquid and solid phases. To replicate the observed bimodal microstructure, solid–liquid interface properties such as thickness, energy, and mobility were systematically varied to reflect the transition from the shot sleeve to the die cavity. The results demonstrated the model’s ability to capture the growth of dendrites under shot sleeve conditions and nucleation and development of new dendrite arms under the rapid cooling conditions of the die cavity.
Methane Emissions in the ESG Framework at the World Level
Authors: Costantiello Alberto , Laureti Lucio , Quarto Angelo , Leogrande Angelo
Published: January 2025

Methane is a strong green gas that has higher GWP. Methane emissions, therefore, form one of the critical focuses within climate change mitigation policy. Indeed, the present study represents a very novel analysis of methane emission within the ESG framework by using the data across 193 countries within the period of 2011–2020. Methane reduction on account of ESG delivers prompt climate benefits and thereby preserves the core environment, social, and governance objectives. In spite of its importance, the role of methane remains thinly explored within ESG metrics. This study analyzes how factors like renewable energy use, effective governance, and socioeconomic settings influence the emission rate of the study subject, as many previous ESG studies are deficient in considering methane. By using econometric modeling, this research identifies that increasing methane emissions remain unabated with the improvement of ESG performances around the world, particularly within key agricultural and fossil fuel-based industrial sectors. Renewable energy cuts emissions, but energy importation simply transfers the burdens to exporting nations. It therefore involves effective governance and targeted internationational cooperation, as socioeconomic elements act differently in different developed and developing countries to drive various emission sources. These findings strongly call for balanced, targeted strategies to integrate actions of mitigation into ESG goals related to methane abatement.
Design and Investigation of a Passive-Type Microfluidics Micromixer Integrated with an Archimedes Screw for Enhanced Mixing Performance
Authors: Waqas Muhammad , Palevicius Arvydas , Jurenas Vytautas , Pilkauskas Kestutis , Janusas Giedrius
Published: January 2025

In recent years, microfluidics has emerged as an interdisciplinary field, receiving significant attention across various biomedical applications. Achieving a noticeable mixing of biofluids and biochemicals at laminar flow conditions is essential in numerous microfluidics systems. In this research work, a new kind of micromixer design integrated with an Archimedes screw is designed and investigated using numerical simulation and experimental approaches. First, the geometrical parameters such as screw length (l), screw pitch (p) and gap (s) are optimized using the Design of Expert (DoE) approach and the Central Composite Design (CCD) method. The experimental designs generated by DoE are then numerically simulated aiming to determine Mixing Index (MI) and Performance Index (PI). For this purpose, COMSOL Multiphysics with two physics modules—laminar and transport diluted species—is used. The results revealed a significant influence of screw length, screw pitch and gap on mixing performance. The optimal design achieved is then scaled up and fabricated using a 3D additive manufacturing technique. In addition, the optimal micromixer design is numerically and experimentally investigated at diverse Reynolds numbers, ranging from 2 to 16. The findings revealed the optimal geometrical parameters that produce the best result compared to other designs are a screw length of 0.5 mm, screw pitch of 0.23409 mm and a 0.004 mm gap. The obtained values of the mixing index and the performance index are 98.47% and 20.15 Pa−1, respectively. In addition, a higher mixing performance is achieved at the lower Reynolds number of 2, while a lower mixing performance is observed at the higher Reynolds number of 16. This study can be very beneficial for understanding the impact of geometrical parameters and their interaction with mixing performance.
Research on Helical Electrode Electrochemical Drilling Assisted by Anode Vibration for Jet Micro-Hole Arrays on Tube Walls
Authors: Yang Tao , Xiao Yikai , Hang Yusen , Wu Xiujuan , Kong Weijing
Published: January 2025

The electrochemical cutting technique, utilizing electrolyte flushing through micro-hole arrays in the radial direction of a tube electrode, offers the potential for cost-effective and high-surface-integrity machining of large-thickness, straight-surface structures of difficult-to-cut materials. However, fabricating the array of jet micro-holes on the tube electrode sidewall remains a significant challenge, limiting the broader application of this technology. To enhance the efficiency and quality of machining these jet micro-holes on the tube sidewall, a helical electrode electrochemical drilling method assisted by anode vibration has been proposed. The influence of parameters, such as the rotational direction and speed of the helical electrode, as well as the vibration amplitude and frequency of the workpiece, on the machining results was investigated using fluid field simulation and machining experiments. It was found that these auxiliary movements could facilitate the renewal of electrolytes within the machining gap, thereby enhancing the efficiency and quality of electrochemical drilling. Using the optimized machining parameters, an array of 10 jet micro-holes with a diameter of 200 μm was machined on the metal tube sidewall. Electrochemical cutting with radial electrolyte flushing tests were then performed through these micro-holes.
Thermithiobacillus plumbiphilus AAFK—Arsenic-Resistant Bacteria Isolated from Arsenopyrite Material
Authors: Shaikin Artem , Zvonarev Anton , Vainshtein Mikhail , Abashina Tatiana
Published: January 2025

Autotrophic sulfur-oxidizing bacteria can play a key role in the metal bioleaching from low-grade sulfide-containing ores. The most commonly used bioleaching group is presented with acidophilic bacteria of the order Acidithiobacillales. We studied the diversity of bacteria in the arsenopyrite gold-bearing ore and also discovered a wide distribution of neutrophilic non-thermophilic bacteria Thermithiobacillus plumbiphilus in this ore, as well as its drainage and flotation concentrate. For the first time, T. plumbiphilus was isolated from the natural arsenic-containing mineral material. The first description of complete genome for the species T. plumbiphilus was also carried out and discovered genes providing the As resistance. Culturing the isolated strain T. plumbiphilus AAFK confirmed the found bacterial resistance to arsenite and cocadylate during the effective thiosulfate oxidation. Experiments on the arsenopyrite bioleaching showed that T. plumbiphilus AAFK can be used as an auxiliary bacterial culture capable of oxidizing reduced / intermediate sulfur compounds. The genetic basis of the T. plumbiphilus AAFK resistance to the arsenic compounds is discussed; the mechanisms are similar with the ones known for acidophilic thiobacilli. The biofilm formation is shown for the first time for T. plumbiphilus; presumably, it could provide some protection and immobilization of the cells. Structures of the T. plumbiphilus AAFK cells and their production of outer membrane vesicles are described and discussed.
Evaluation of In Vitro Production Capabilities of Indole Derivatives by Lactic Acid Bacteria
Authors: Ma Bingyang , Zhao Yan , Liu Liping , Xu Jianguo , Hu Qingping , Feng Saisai , Zhang Liangliang
Published: January 2025

Lactic acid Bacteria (LAB) convert tryptophan to indole derivatives and induce protective IL-22 production in vivo. However, differences in metabolizing capabilities among LAB species have not been widely investigated. In the present study, we compared the capabilities of 186 LAB strains to produce four kinds of indole derivatives, including indole-3-carboxaldehyde (IAId), indole-3-lactic acid (ILA), indole-3-propanoic acid (IPA), and indole-3-acetic acid (IAA). These strains were isolated from fermented foods, dairy products, and the feces of healthy individuals, as well as from fish and shrimp from Shanxi and Jiangsu provinces. They represent 15 genera, including Bifidobacterium, Enterococcus, Lacticaseibacillus, Lactiplantibacillus, Lactobacillus, Lactococcus, Limosilactobacillus, Pediococcus, Streptococcus, Weissella, Latilactobacillus, Levilactobacillus, Ligilactobacillus, and Loigolactobacillus. The results indicate widespread IAId-producing capabilities in LAB strains, with positive rates of approximately 90% (106/117) and 100% (69/69) among strains from Shanxi and Jiangsu provinces, respectively. The concentrations of IAId ranged from 72.42 ng/mL to 423.14 ng/mL in all positive strains from Shanxi Province and from 169.39 ng/mL to 503.51 ng/mL in strains from Jiangsu Province. Intriguingly, we also observed specific ILA-producing capabilities in Lactiplantibacillus strains, with positive rates of 55.17% (16/29) and 80.95% (17/21) among strains isolated from Shanxi and Jiangsu provinces, respectively. The overall detection rates of ILA among all tested strains (including both Lactiplantibacillus and other genus strains) were 17.9% (21/117) and 26.1% (18/69). The concentrations of ILA in positive strains ranged from 12.22 ng/mL to 101.86 ng/mL and from 5.75 ng/mL to 62.96 ng/mL from Shanxi and Jiangsu provinces, respectively. IPA and IAA were not detected in any strains. Finally, these indole derivative-producing capabilities were not related to their geographical origins or isolation sources. The current study provides insights into the species- or genus-dependent capabilities for metabolizing indole derivatives. Defining the specific roles of LAB in indole derivative metabolism will uncover the exact physiological mechanisms and be helpful for functional strain screening.
U-Pb and Hf Isotopic Analyses for Detrital Zircon of the Danzhou Group in the Western Jiangnan Orogenic Belt and Tectonic Implications
Authors: Liu Jingna , Huang Xianglin , Xia Xiyue , Li Xiuping
Published: January 2025

In order to better constrain the specific depositional age and provenance of the Danzhou Group and understand the geological evolution of the Jiangnan Orogenic Belt, we conducted a combined U-Pb and Hf-isotope analysis of detrital zircons from the Gongdong and Hetong formations of the Danzhou Group in the Longsheng area of the Western Jiangnan Orogenic Belt. Detrital zircons from the Gongdong Formation yield three age populations of 2658–2517 Ma, 2427–1678 Ma and 891–781 Ma, and the youngest ages suggest that the sedimentation began after ca. 783 Ma. U-Pb ages of detrital zircons from the Hetong Formation yield major populations at 2769–2502 Ma, 2492–2100 Ma, and 991–731 Ma, and the youngest ages redefine the maximum depositional age of this unit is 760 Ma, much younger than previously considered. Thus, the upper part of the Hetong Formation in the Longsheng area is newly subdivided into the Sanmenjie Formation, which is characterized by a large amount of 765–761 Ma volcanic rocks. The dominant 991–731 Ma detrital zircons for all samples were likely sourced from the Neoproterozoic igneous rocks of the southeast margin of the Yangtze Block. The subordinate 2494–1678 Ma detrital zircons were probably sourced from the Cathaysia Block. Minor amounts of 2769–2502 Ma detrital zircons may have been sourced from the Yangtze Block. Detrital zircons from the Gongdong Formation have mainly negative εHf (t) values (−1.1 to 21.8, 90%), suggesting that the detritus of the Gongdong Formation is dominated by the recycling of old crustal materials. The εHf (t) values of detrital zircons from the Hetong Formation have a large spread of −22.2 to +9.7, indicating that the source material of the Hetong Formation includes both the juvenile crustal materials and the recycled ancient crustal materials. The above age populations and Hf isotopic characteristics are consistent with the magmatic rocks in the Jiangnan Orogenic Belt and the Southeast Yangtze Block. Taking into account the lithostratigraphic features, provenances, and depositional ages, the Danzhou Group in the Western Jiangnan Orogenic Belt was deposited in a back-arc basin.
Continuous Production of Docetaxel-Loaded Nanostructured Lipid Carriers Using a Coaxial Turbulent Jet Mixer with Heating System
Authors: Lim Hyeon Su , Choi Won Il , Lim Jong-Min
Published: January 2025

The continuous synthesis of nanoparticles (NPs) has been actively studied due to its great potential to produce NPs with reproducible and controllable physicochemical properties. Here, we achieved the high throughput production of nanostructured lipid carriers (NLCs) using a coaxial turbulent jet mixer with an added heating system. This device, designed for the crossflow of precursor solution and non-solvent, combined with the heating system, efficiently dissolves solid lipids and surfactants. We reported the flow regime according to the Reynolds number (Re). Also, we confirmed the size controllability of NLCs as dependent on both Re and lipid concentration. The optimized synthesis yields NLCs around 80 nm, ideal for targeted drug delivery by enhanced permeability and retention (EPR) effect. The coaxial turbulent jet mixer enables effective mixing, producing uniform size distribution of NLCs. The NLCs prepared using the coaxial turbulent jet mixer were smaller, more uniform, and had higher drug loading compared to the NLCs synthesized by a bulk nanoprecipitation method, showcasing its potential for advancing nanomedicine.
Crystal Structures of d-Lyxono-1,4-lactone and Its O-Tosyl Derivative
Authors: Sosnowska Anna , Chojnacki Jarosław , Samaszko-Fiertek Justyna , Madaj Janusz , Dmochowska Barbara
Published: January 2025

γ- and δ-lactones were formed by bromine oxidation of commercially available D-lyxose, as confirmed by IR analysis. The former was isolated, and its structure was confirmed by NMR spectra and X-ray analysis. In this structure, the presence of both intermolecular and intramolecular hydrogen bonds was found. Intermolecular interactions in the crystal were illustrated using the Hirshfeld surfaces. Due to steric reasons, 3,5-O-isopropylidene-d-lyxono-1,4-lactone was formed, which in a further step led to the formation of a 2-O-tosyl derivative. Its structure was confirmed by X-ray diffraction analysis. The additional ring of the O-isopropylidene derivative caused the lactone ring to change conformation to 3E. In the crystal structure of this compound, only C-H⸱⸱⸱O intermolecular interactions were present, as confirmed by the Hirshfeld surface analysis.
Uncovering the Metabolic Footprint of New Psychoactive Substances by Metabolomics: A Systematic Review
Authors: Almeida Ana Sofia , Pinho Paula Guedes de , Remião Fernando , Fernandes Carla
Published: January 2025

New psychoactive substances (NPSs) emerged in the 2000s as legal alternatives to illicit drugs and quickly became a huge public health threat due to their easy accessibility online, limited information, and misleading labels. Synthetic cannabinoids and synthetic cathinones are the most reported groups of NPSs. Despite NPSs being widely studied, due to their structural diversity and the constant emergence of novel compounds with unknown properties, the development of new techniques is required to clarify their mode of action and evaluate their toxicological effects. Metabolomics has been a useful tool to evaluate the metabolic effects of several xenobiotics. Herein, a systematic review was performed, following PRISMA guidelines, regarding metabolomic studies on synthetic cathinones and synthetic cannabinoids to evaluate their effects in cellular metabolism. In the studies, in vivo models were the most employed (86%) and the analysis mostly followed untargeted approaches (75%) using LC-MS techniques (67%). Both groups of NPSs seem to primarily interfere with energy metabolism-related pathways. Even though this type of study is still limited, metabolomics holds great promise as a tool to clarify mechanisms of actions, identify biomarkers of exposure, and explain the toxicological effects of NPSs.