bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive value of serum Klotho protein level in assessing: cardiovascular risk, achievement of the end stage of CKD, and overall survival of patients with initial CKD C3-4: a prospective clinical analysis (follow-up period of 8 years)
Authors: Milovanova L. Yu. , Volkov A. V. , Milovanova S. Ya. , Taranova M. V. , Nezhdanov K. S.
Published: January 2025

BACKGROUND. Cardiovascular complications (CVС) are the leading cause of death in a cohort of CKD patients, including young working age people. The search for a prognostic marker that allows predicting and preventing the risk of CVС is an important not only medical but also socioeconomic task.

THE AIM OF THE STUDY: To determine the predictive value of baseline serum Klotho levels in assessing cardiovascular risk, risk of developing end-stage renal disease (ESRD), and overall survival among patients with stage 3-4 CKD, during an 8-year follow-up period.

PATIENTS AND METHODS: The study included 75 patients with CKD C3-4, mean age 54+9 years. The initial serum Klotho level was divided into quartiles (1 quartile Klotho – 148-336 pg/ml; 2-3 quartile – 337-580 pg/ml; 4 quartile – 580-812 pg/ml). The overall survival of patients over a period of 8 years, the cause of death, and the achievement of ESRD, depending on the Klotho quartile, were assessed. RESULTS: During the observation period, 22 patients died, of which 12 (54.5 %) died from CVC, 7 (31.8 %) from covid infection, 3 (13.6 %) from other causes. When assessed by quartiles, patients with the 1st quartile prevailed among the deceased patients, including those from CVC: the 1st quartile was – 9 (75.0 %), the 2nd-3rd quartile -3 (25.0 %), the 4th quartile – 0 ( 0 %), (chi-square = 8.2, p=0.023). Among patients who achieved ESRD and started dialysis (n=30), patients with 1 quartile were 12 (63.2 %), 2-3 quartile -16 (43.2 %), 4 quartile – 2 (10.5 % ), (chi-square = 11.3, p = 0.01). Among the surviving patients (n=53) with CVC on the moment of end study (n=28), patients with 1 quartile were 19 (67.9 %), 2-3 quartile 9 (32.1 %), 4 quartile – 0 % (chisquare=19.9, p<0.001). At the same time, among the entire sample of patients, there was no correlation of the Klotho level with age (r=-0.067, p=0.570), CKD stage (r=-0.281, p=0.06). In the same time, there was a statistically significant correlation of Klotho level with the achievement of ESRD by the patient and the beginning of dialysis (r=-0.465, p<0.001), the development of CVC (r=-0.512, p<0.001), overall survival (r=-0.368, p=0.001).

CONCLUSION: According to our data, the serum level of Klotho did not depend on the age of patients or the stage of CKD (in the sample of patients with 3-4 stages of CKD), however, it was clearly associated with the risk of cardiovascular events, the risk of progression of CKD to ESRD, overall survival of patients and can be considered as prognostic marker in patients with pre-dialysis stages of CKD.
Analysis of the effectiveness of anemia correction in CKD stage 5 on the basis of the "V.A. Baranov Republican Hospital" in Karelia Republic
Authors: Smirnova D. V. , Barysheva O. Yu. , Tikhova G. P.
Published: January 2025

BACKGROUND. Nephrogenic anemia is a serious problem in patients with chronic kidney disease, requiring a careful approach and adequate treatment. This condition manifests at the first stage and steadily progresses as GFR decreases. Therefore, timely correction of renal anemia with iron supplements and erythropoiesis stimulate agents (ESA) in CKD C5 is an integral component of therapy to reach target Hb values.

THE AIM. This paper provides an analysis of the effectiveness of erythropoiesis-stimulating therapy among patients with end-stage CKD (C5d) receiving treatment with program hemodialysis on the basis of the Republican hospital named V.A. Baranov.

PATIENTS AND METHODS. During the year 2022, 107 patients with end-stage CKD were observed. All of them had been receiving renal replacement therapy through a hemodialysis program (1284 patientmonths) and erythropoiesis-stimulating therapy with monthly monitoring of hemoglobin levels, following the clinical guidelines «Anemia in chronic kidney disease – 2020-2021-2022».

RESULTS. The median hemoglobin level for 2022 was 107.8 g/L. The average annual increase was 8.9 g/l. Overall, the hemoglobin level in patients who did not receive EPO was 115.5 g/l. Patients receiving EPO who did not reach the target hemoglobin level (IR: 100-120 g/L) had a median hemoglobin of 92.5 g/L. To achieve the presented levels of anemia correction, the average weekly dose was 6,785 IU when calculated for the entire year 2022, including those patient months when EPO was not used.

CONCLUSIONS. During treatment with EPO drugs, an increase in hemoglobin levels is observed, patients' quality of life improves, the risks of cardiovascular complications decrease, performance and physical endurance increase, the frequency and duration of hospitalizations decrease, and the need for blood transfusions decreases. The main challenges in solving the problem of refractory anemia involve individualizing treatment, considering drug response, and identifying additional factors.
Differences in White Blood Cells, Neutrophil-to-Lymphocyte Ratio, Tumor Necrosis Factor-α based on Procalcitonin Level in Community-Acquired Pneumonia Patients
Authors: Sutanto Yusup Subagio , Apriningsih Hendrastutik , Syaikhu Akhmad , Siregar Sihsusetyaningtyas Tiominar
Published: January 2025

Background: Community-acquired pneumonia (CAP) is a respiratory infectious disease caused by bacteria, viruses, or fungi. Procalcitonin (PCT) levels will rise, especially in bacterial infection. PCT examination in CAP can help to confirm the diagnosis and anticipate complications. CAP is diagnosed by symptoms, vital signs, laboratory tests, and radiographic investigations. Inflammatory biomarkers are required for predicting causative microorganisms, guiding antibiotic therapy, and determining severity. The purpose of this study is to compare NLR, WBC, and TNF-α levels in CAP patients dependent on PCT level.Methods: This was an analytical cross-sectional study involving 43 CAP patients admitted to Universitas Sebelas Maret (UNS) Hospital and Moewardi Regional General Hospital Surakarta between February and March 2023. Patients were separated into two groups based on PCT levels: those with levels ≤0.12 ng/mL and >0.12 ng/mL. All patients provided a blood sample for NLR, WBC, TNF-α, and PCT testing. The independent t-test and Mann-Whitney tests were performed for statistical analysis of two unpaired groups, and the Chi-square or Fisher exact test was utilized for ordinal categorical data. If the value of P<0.05, the result is statistically significant.Results: NLR and TNF-α levels were higher in the PCT group >0.12 ng/mL and statistically significant with a value of P=0.001. WBC levels in the PCT group >0.12 ng/mL were higher, but the difference was not statistically significant (P=0.096).Conclusion: The NLR value, WBC, and TNF-α levels were found to be higher in the group with PCT >0.12 ng/mL.
Potential of Emodin as Effective Therapy Overcoming COVID-19 Through Inhibition of the SARS-CoV-2 Spike Protein Interaction on ACE2 Receptors
Authors: Ilham Ahmad Fadhil , Handayani Diah
Published: January 2025

Background: The coronavirus disease 2019 (COVID-19) once became a major pandemic in the history of human health. Patients in severe to critical conditions, especially with comorbidities, are more likely to have complications such as ARDS, cytokine storm, higher mortality rates, and require more effective treatments. Emodin is a candidate regimen that has the potential benefit for COVID-19.Method: This literature review was synthesized with literature searches on journal databases such as PubMed, ScienceDirect, EMBASE, and the Google Scholar search engine. As a result, three main articles and 36 supporting articles were used to synthesize this literature review.Results: The pathogenesis of SARS-CoV-2 infection was similar to SARS-CoV infection, as demonstrated by Hoffmann et al, namely through the interaction of viral spike (S) protein with ACE2 receptors in the human body, so the inhibition of this interaction would be one of the therapeutic targets. Ho et al proved that emodin can inhibit the binding of the SARS-CoV S protein to ACE2 in vitro. The direct inhibition of S protein may also support the ACE2 cardioprotective function in patients with cardiovascular comorbidities. Emodin is also superior because it has various other benefits such as anti-inflammatory and immunosuppressive activity. Based on the research of Dong et al, emodin can be given orally but in combination with inhibitors of glucuronidation, metabolism can increase the bioavailability of this drug.Conclusion: Emodin has the potential to be developed for the effective therapy of COVID-19.
Expiratory Carbon Monoxide Levels of Cigarette Smokers in College Environment
Authors: Sumarsudi Karel Handito Syafi , Damayanti Triya
Published: January 2025

Background: The impact of smoking is still a huge problem in the world. The use of cigarettes is one of the biggest causes of death that can be prevented. One of the harmful substances of smoking is carbon monoxide (CO). Unfortunately, research comparing CO levels in white and Kretek cigarette smokers among college students in Indonesia has not been conducted. This study aims to determine the relationship of expiratory CO levels in male students who smoke white or Kretek cigarettes at a university in Depok using a CO analyzer and questionnaire.Methods: This is a cross-sectional study design with 108 samples divided into two groups of white cigarette smokers and Kretek cigarette smokers with consecutive sampling techniques. Subjects took the expiratory CO test using a CO analyzer and filled out questionnaires related to smoking and other factors.Results: The study found expiratory CO results in white cigarette smokers at 13.9±8.36 ppm and Kretek cigarette at 13.18±8.79 ppm with no significant relation statistically. The factor that influences the subject's CO expiration is the Brinkman Index (P<0.001) with a weak correlation result and factors that influence the choice of cigarette type, namely pocket money (P=0.023) and age (P=0.015).Conclusion: There was no statistically significant relationship between the average of white cigarette smokers or Kretek cigarette smokers with expiratory CO levels in subjects. This might be due to a more significant effect on the number of cigarettes consumed. Seeing the trend in Indonesia that Kretek cigarettes are relatively cheaper than white cigarettes, money allowance is one of the factors that determine the choice of white or Kretek cigarettes for college students in Depok.
ВЛИЯНИЕ ХЕЛАТИРОВАННОЙ ФОРМЫ ЖЕЛЕЗА НА УРОВЕНЬ
ЕГО НАКОПЛЕНИЯ В КРИТИЧЕСКИХ ОРГАНАХ И ТКАНЯХ
Authors: Берсанова А.Э. , Исраилова М.Х. , Сагаева Э.Л.-А.
Published: January 2025

Применение комплексоната железа в условиях биогеохимичности региона приводит к повышению концентрационного статуса данного элемента в рубцовой жидкости, крови и хвостовых волосах.
THE INFLUENCE OF DIGITAL LITERACY AND INFORMATION LITERACY ON CRITICAL THINKING SKILLS AMONG TEACHER EDUCATION STUDENTS
Authors: Jescel Kristine A. Mosquete  , Mary Ann Ronith P. Libago
Published: January 2025

This study determined the influence of digital literacy and information literacy on critical thinking skills among teacher education students. Quantitative research design utilizing descriptive-correlational approach was used in this study. The data were gathered from 147 third-year teacher education students of Kapalong College of Agriculture, Sciences and Technology (KCAST) through stratified random sampling. Findings revealed that the levels of digital literacy and information literacy were both high; and the level of critical thinking skills was high. Results also revealed that there were high, positive, and significant relationships among the variables: digital literacy and critical thinking skills; and information literacy and critical thinking skills. Moreover, results showed that domains of digital literacy such as critical thinking, citizenship, and curation can significantly influence critical thinking skills. Finally, it was revealed that domains of information literacy such as information knowledge, information skills, and information morality can significantly predict critical thinking skills. Results imply that the variables are significant in improving the critical thinking skills of teacher education students.
KEYWORDS: Digital Literacy, Critical Thinking Skills, Information Literacy, Teacher Education Students, Philippines
EVALUATION OF THE MEAT SEMI-FINISHED PRODUCTS OF THE YAKUTIA MEAT PROCESSING ENTERPRISE
Authors: Tatarinova zinaida , Shestakova Diana
Published: January 2025

The purpose of research is to assess the quality of frozen semi-finished beef meat products manufactured at a processing plant in Yakutia in terms of compliance with the requirements of regulatory documents and standards for control methods. Samples of frozen minced molded meat (cutlets, meatballs) and small-sized semi-finished products of the agricultural consumer cooperative Berte-As of the Khangalassky ulus of the Republic of Sakha (Yakutia) were evaluated by organoleptic, physico-chemical and bacteriological indicators. Samples of cutlets, meatballs were studied for indicators characterizing external and taste qualities: physical and chemical indicators – acidity, mass fraction of moisture, mass fraction of sodium chloride, qualitative and quantitative methods for determining starch, mass fraction of bread; bacteriological indicators – bacterial contamination, the presence of opportunistic and pathogenic microorganisms (salmonella, listeria Listeria mnocytogenes, etc.), the presence of mold. According to the results of the analysis of the composition and chemical analysis of chopped semi-finished products, the category of products was determined. Samples of small-sized semi-finished products were examined for organoleptic characteristics, bacterial contamination, the presence of opportunistic and pathogenic microorganisms. According to the results of the veterinary and sanitary examination of frozen minced meat, small-sized semi-finished products produced by the agricultural consumer cooperative Berte-As, it was found that the products are made from high-quality natural meat raw materials of category B, comply with the requirements of technical regulations, specifications and standards for control methods in terms of safety indicators.
THE IMPORTANCE OF PCR IN THE INFECTIOUS AGENTS DETECTION IN CATTLE
Authors: Bezborodova Natalia , Kozhuhovskaya Veronika , Poryvaeva A , Shilova E. , Pechura Elena
Published: January 2025

The aim of our work was to identify bacterial and viral infectious agents in biological material from cows and calves with different clinical manifestations of diseases by PCR. Biological materials from animals were sent to the PCR laboratory from 23 agricultural organizations in the Ural Region. A total of 808 samples were studied, of which genomes of pathogens were found in 11.9 % of cases: Mycoplasma bovis DNA in 2.4 % of samples, Bovine virus diarrhoea RNA in 2.3 % of samples, Mycoplasma spp. and Chlamydia spp DNA in 2 % of samples, Mycoplasma bovigenitalium, Bovine herpesvirus (type 1), Chlamydophila abortus, Chlamydophila pecorum were found singly. Out of 80 samples in 36.2 % of biomaterials, specific DNA sites of Cl. difficile were found – 31.2 % of samples, Cl. perfringens – 20.0 % of samples, Cl. difficile + Cl. perfringens – 25.0 % of biosamples. Toxins were found in Cl. difficile: CDT toxin in 41.0 % of clostridia, toxin B in 6.0 % of pathogens, less often toxin A. In some cases, clostridia (Cl. perfringens, Cl. difficile B) were found in the biomaterial from dead calves, which confirmed the diagnosis – infectious anaerobic enterotoxemia of calves. Bacteria (E. coli, Salmonella enterica spp. entericaserogroup C (0:9, 2), Cl. perfringens and Cl. difficile CDT DNA) were detected in the biomaterial from dead cows, which confirmed the diagnosis of acute intestinal infection. All detected pathogens were presented in the form of monoinfection and singly in the form of mixed infections. Using PCR, it was possible to detect DNA and RNA of infectious agents in various clinical manifestations of diseases of bacterial and viral etiology in cattle herds in the Ural Region.
HEMP CAKE INFLUENCE ON DIGESTIBILITY AND RUMEN METABOLISM IN VITRO
Authors: Denisenko Konstantin , Duskaev Galimzhan , Nurzhanov Baer
Published: January 2025

The purpose of research is to study the effect of various doses of hempseed cake on the in vitro digestibility of the dry matter of concentrated feed and rumen metabolism. The experiment was carried out on the basis of the Center for Collective Use of the Federal Scientific Center of the BST RAS on the "artificial scar" model using the ANKOM Daisy II incubator (modifications D200 and D200I). 4 samples were prepared in three repetitions: Control group – grain mixture 100 %; Group I – grain mixture 86 % + hemp cake 14 %; Group II – grain mixture 80 % + hemp cake 20 %; Group III – grain mixture 74 % + hemp cake 26 %. It was found that the introduction of hemp cake in different dosages into a sample with dry matter of barley grain contributed to its digestibility by 1.5 %, 3.81 and 4.82 % compared to the control. At the same time, the sample in group III, containing 26 % hemp cake, was distinguished by the best digestibility. The content of total nitrogen in the rumen fluid of group III was 36.4 mg/%, 37.8 and 35.0 mg/% more than in the control, I and II groups, respectively. The control sample was inferior to I and III groups by 8.28 and 17.14 %. The largest amount of ammonia nitrogen was noted in the rumen fluid from group III, by 0.7 mg/% relative to the control. content by 41.71 %. As for the protozoa, there is a consistent increase in their number in all experimental groups – by 24.24 %, 52.27 and 139.39 %, in comparison with the control.
SURGICAL CORRECTION OF DEGENERATIVE LUMBOSACRAL STENOSIS IN DOGS
Authors: Vilkovyskiy Il'ya , Vatnikov Yu , Yagnikov Sergey , Shpin'kov Dmitriy , Rusnak Ivan
Published: January 2025

The purpose of the study is to conduct a comparative evaluation of various methods for the correction of degenerative lumbosacral stenosis in dogs and to determine the most effective method. 32 dogs of various breeds and mestizos aged from one to 9 years were under observation. 8 dogs underwent surgery to correct degenerative lumbosacral stenosis by dorsal laminectomy followed by stabilization of L7-S1 screws 3.5–4.5 mm in diameter and polymethyl methacrylate. 24 dogs were operated on by the dorsal laminectomy method with the installation of the L7-S1 transpedicular system. Performing a dorsal laminectomy with L7-S1 stabilization with screws and bone cement is technically more difficult due to the impossibility of suturing the muscles over the metal structure, which in the early postoperative period is fraught with purulent complications due to the impossibility of creating a muscle frame over the cement fixator. In such cases, the risk of septic complications was significantly increased. Also, during revision operations, it becomes difficult to remove the cement and replace it if necessary. As a result of the studies, it was proved that dorsal laminectomy and installation of the L7-S1 transpedicular system ensures the disappearance of clinical signs of stenosis and rehabilitation of the animal in a shorter postoperative period, while providing unique opportunities for reoperation in cases of complications.
DEVELOPMENT OF VEGETABLE OIL BLENDS WITH A BALANCED FATTY ACID COMPOSITION
Authors: Naumova N. , Bec Yuliya
Published: January 2025

The aim of the study is to develop mixtures of vegetable oils with a ratio of ɷ6:ɷ3 PUFA in the range of 5–10:1. Tasks: to study the quality indicators of vegetable oils; to investigate the fractional composition of PUFA; apply mathematical modeling methods in the development of blends of vegetable oils. The results of the development of blends of vegetable oils with a ratio of polyunsaturated fatty acids (PUFA) ɷ6:ɷ3 in the range of 5–10:1 are presented. Organoleptic (color, transparency, taste and smell), physico-chemical (peroxide and acid numbers, vitamin E content) indicators and fractional composition of PUFA refined deodorized oils – sunflower of the first grade (manufacturer OOO Tovarnoe hozyajstvo (limited liability company), Saratov Region), rapeseed of the highest grade (OOO Armaz (limited liability company), Novosibirsk), corn brand "P" (AO Efko (joint-stock company), Belgorod Region) and unrefined cold-pressed chia oil (OOO Sibirskaya kletchatka (limited liability company), Tomsk Region). The compliance of the quality indicators of traditional oils with the norms of the current GOSTs and TR CU 024/11, chia oils with the requirements of the Codex Alimentarius, has been established. Codex Stan 210-1999 and TR TS 024/11. Good compatibility of the studied oils in terms of organoleptic characteristics for blending was revealed. A relatively high content of ά-tocopherol was found in sunflower (667.16±14.22 mg/kg) and rapeseed (554.63±10.14 mg/kg) oils, and relatively low content in corn (78.07±2.24 mg/kg), the average level is in chia oil (343.96±9.03 mg/kg). In all oils, an imbalance of PUFAs was determined: with a predominance of the ɷ6 (linoleic-cis acid) fraction – in traditional oils, the ɷ3 (ά-linolenic acid) family – in chia oil. With the help of mathematical modeling methods, where the “maximum content of vitamin E” and “minimum price” were the accompanying criteria, 6 blends were developed with a certain ratio of sunflower refined deodorized oil of the first grade (93.37–96.70 %) and unrefined sunflower oil cold-pressed (6.63–3.30 %), characterized by a balanced composition of ɷ6 and ɷ3 PUFAs in accordance with the regulated norms MP 2.3.1.0253-21.
EFFICIENCY OF USING SAVE FRESH IN THE GINGER SHORT-TERM STORAGE TECHNOLOGY
Authors: Karpova Natal'ya , Sokolova Lyubov' , Kulishov Vsevolod , Tkachenko Gennadiy , Sychev R. , Maslovsky Sergey
Published: January 2025

In the structure of vegetable products imported to the Russian Federation, a fairly large share is occupied by the supply of ginger. According to the data of 2021 in the federal network X5 Riteil Group, the volume of its supply and sale amounted to 991.976 thousand tons. A significant problem in organizing the supply of this type of product is significant losses from a complex of fungal and bacterial diseases, infection with which can occur at the stages of its cultivation, storage in places of production and transportation. Treatment of rhizomes with Save Fresh, the active substance of which is sodium sorbate (E-201), was considered as a method aimed at reducing the loss of ginger from diseases. The drug, produced in aerosol form, is sprayed inside the vehicle and forms a protective layer on the surface of the rhizomes. Untreated samples served as controls. For phytopathological studies, before laying the experiment, rhizomes were selected that were visually healthy and with visible signs of damage by myromycetes. According to the results of identification, in untreated rhizomes with visible lesions, a pathocomplex was identified, which included bacterial rot and micromycetes – Acremonium, Pennicilium, Fusarium, Helminthosporium. In outwardly healthy rhizomes, according to the layout, approximately the same complex of pathogens was observed, and according to the results of flushing, bacteriosis and Alternaria in a weak form were observed. After treatment with the drug, there was no change in the composition of pathogens identified in the layout, but there were no micromycetes in the swabs and only bacterial rot was noted. After 16 days of storage at a temperature of 13°C, healthy rhizomes were identified with bacterial rot and Fusarium. Under the influence of treatment with Save Fresh, there was a slight increase in the value of the natural weight loss during storage, as well as a more intensive decrease in the dry matter content during storage. At the same time, there was a tendency to increase the content of sugars and carotenoids in the rhizomes. Based on the experience, it can be concluded that the studied drug has an inhibitory effect on epiphytic pathogenic microflora, identified by the analysis of swabs.
MASS CONCENTRATION OF VOLATILE SUBSTANCES IN WINES FROM RED INDIGENOUS GRAPE VARIETIES OF DON AMPELOGRAPHIC COLLECTION NAMED AFTER Ya.I. POTAPENKO
Authors: Matveeva Natal'ya , Bahmetova Marina
Published: January 2025

The purpose of research is to study the qualitative and quantitative indicators of the main food additives, volatile components and aromatic acids in wines from red native grape varieties of the Don ampelographic collection named after Ya.I. Potapenko (Novocherkassk). The objects of the study were must and wine from red technological varieties: Cimlyanskij chernyj, Krasnostop Zolotovskij and Varyushkin. Research was based on laboratory winemaking technologies. Pilot production of wines are produced in the conditions of micro-winemaking on the chemical technology of production of dry red wines. The wort has significant values of indicators: the amount of phenols, mass concentrations of total and amine nitrogen, pH, glucoacidometric index (GAI), technical maturity index (TMI), mass concentration of anthocyanins. After the end of fermentation, the content of alcohol, titratable acids, volatile acids, residual sugars, and reduced extract was determined. The organoleptic characteristics of the studied wine varieties were carried out according to a 10-point system by the tasting commission of the institute. According to the content of resveratrol, a sample from the Krasnostop Zolotovskij variety stood out – 4.48 mg/dm3. Ascorbic, chlorogenic, nicotinic, orotic, caffeic and gallic acids were determined in all wine materials. The background components of the aromatics of the studied wines are represented by volatile fermentation products (acetaldehyde, methyl acetate, ethyl acetate, methanol, 2-propanol, 1-propanol, isobutanol, 1-butanol). In the studied samples of red wines, these components were found in threshold values, which had a positive effect on the taste and aromatic qualities of the final product and made it possible to obtain high tasting scores for all samples. It can be concluded that all the studied varieties not only have high organoleptic ratings, but also contain a valuable biological component - resveratrol, which has a positive effect on human health, as well as unique aroma-forming substances (phenolcarboxylic acids, higher alcohols, aldehydes, etc.).
PRODUCTIVITY OF LEAF MASS OF CELASTRUS ORBICULATUS THUNB. (CELASTRACEAE) IN THE CONDITIONS OF THE MOSCOW REGION
Authors: Savinov Ivan , Solomonova Ekaterina , Trusov Nikolay , Simakov Grigoriy
Published: January 2025

The genus Celastrus L. includes about 35 species of deciduous or evergreen climbing shrubs, most often large lianas with alternate leaf arrangement. Bittersweets grow in Australia, Madagascar, America, as well as East and Southeast Asia, including the Russian Far East. Celastrus orbiculatus Thunb. – one of the most popular types of bittersweets, widely used in Russia, including the Moscow Region, for vertical gardening. In addition to being decorative, some parts of the plant are edible and potentially medicinal. The currently available data on the leaf productivity of C. orbiculatus plants is not enough for a comprehensive assessment of the correspondding plant material, as well as its implementation in practice, primarily due to the lack of information on the size and weight characteristics of shoots and leaves. The purpose of the study is to evaluate the productivity of the leaf mass of Celastrus orbiculatus Thunb. in the conditions of the Moscow Region. The objects of study are 20 one-year-old highly elongated shoots of the liana C. orbiculatus from the arboretum of Tsitsin Main Botanical Garden, Russian Academy of Sciences. Weighing and measuring the length and width of leaves from each shoot (17–46 leaves, 32 on average) were carried out, starting from the top leaf. It was established that C. orbiculatus has highly variable sizes (5.27±0.14 × 3.52±0.11 cm) and weight (0.19±0.01 g, up to 0.30±0.02 g ) leaves of typical shape. Despite the fact that the leaves do not reach their maximum length, as in natural conditions, C. orbiculatus successfully grows in the conditions of the Moscow Region, being distinguished by high leaf productivity.
SOFT SPRING WHEAT YIELD ENVIRONMENTAL RESPONSE TO CHANGES IN NATURAL CONDITIONS IN SPACE AND TIME
Authors: Shostak Mariya , Ermekov Farabi , Zagrebel'nyy Taras , Makenova Saule , Tatarincev Vladimir , Tatarintsev L , Muzyka Olesya
Published: January 2025

The purpose of the study is to determine the dependence of the yield of soft spring wheat on climatic conditions in the time lag and in natural zones using the example of the Altai Region. Objectives: to determine the variation in the yield of spring soft wheat for 2016–2020, research on the subzones of the Altai Region; to calculate specific conditions and evaluate the effect of hydrothermal conditions on the yield of soft spring wheat. The object of the study was soft spring wheat and its productivity. It was found that the sustainability of agricultural land use in the Altai Region depends on environmental conditions and factors affecting the ecological response (yield) of wheat in the subzones of the region. Yields were studied for five years in five subzones. It was found that the variation (decrease) in the yield of spring wheat by subzones in the studied time lag occurs as you move from east to west of the region. This is evidenced by the interval and range of variation, arithmetic mean, standard deviation and other statistical values calculated by zones and years of study. Next, according to the HTC value, the years were ranked and the specific conditions of the spring wheat yield were determined. At the next stage of the work, the calculation of the general information content and the coefficient of efficiency of information transfer from the hydrothermal coefficient to the yield of spring soft wheat were carried out. It has been reliably established that in all subzones, the formation of the crop is largely influenced by the HTC in the first half of the growing season (May–June), and to a lesser extent in July–August. The results of the study can be used in forecasting the grain harvest and the formation of domestic consumption and exports.
GASTROINTESTINAL TRACT LESIONS IN CATTLE BY CANDIDA ALBICANS FUNGI
Authors: Potehina Ramziya , Tremasova A , Kalimullin Farit , Milovankin Dmitriy , Biryulya V , Tremasov Yuriy , Sagdeeva Zuhra
Published: January 2025

The purpose of the study is to analyze the localization of yeast-like fungi of the genus Candida in the oral cavity and gastrointestinal tract in cattle. The selection of the material was carried out at the Yelabuga Meat-Packing Plant JSC of the Republic of Tatarstan from May to July 2021. The carcasses of dairy cows aged 4–5 years with signs of a fungal disease of the gastrointestinal tract were subjected to the study. Visual examination and screening of the organs of the oral cavity, gastrointestinal tract were carried out by veterinarians in accordance with the "Rules for the veterinary examination of slaughter animals and the veterinary and sanitary examination of meat and meat products" (approved by the Main Veterinary Directorate of the USSR Ministry of Agriculture on December 27, 1983, with amendments and as amended on June 17, 1988). Laboratory studies of cattle carcasses for the presence of infectious agents were fulfilled in accordance with the "Procedure for sanitary and microbiological control in the production of meat and meat products" (approved by the Department of Food and Processing Industry of the Ministry of Agriculture and Food of Russia on December 15, 1995). Thus, the conducted studies allow us to conclude that the causative agents of mycoses Candida albicans are permanent inhabitants of the oral cavity, gastrointestinal tract (rennet, net, book, thick and small intestines) in cattle. Only early diagnosis, timely treatment and elimination of opportunistic microorganisms can save the number of dairy cows and prevent the threat of development and spread of candidal endometritis.
ANATOMICAL AND HISTOLOGICAL FEATURES OF THE REGIONAL STOMACH LYMPH NODES IN DOGS
Authors: Skladneva Evgeniya , Rachinskiy Yu , Semenkovich Olesya
Published: January 2025

The paper describes the local features of the regional lymph nodes of the stomach in dogs. Research was carried out at the Khakass State University named after N.F. Katanov (Republic of Khakassia) on autopsy and biopsy material obtained from 34 male and female healthy outbred dogs aged 2 to 6 years. In the course of the study, the methods of intratissue injection of the lymphatic bed with colored dyes, preparation, making stained total preparations from the capsule of the lymph nodes, histological sections, light and electron microscopy were used. The regional lymph nodes of the stomach in dogs are gastric, pancreaticoduodenal, splenic, and hepatic lymph nodes. Regional lymph nodes of the stomach in dogs have a typical structure for these organs. The contractility of the capsule of the lymph nodes is determined by the quantitative and spatial distribution of smooth myocytes of its middle layer, which have local features. In the zone of muscle strands, myocytes lay in strands in several layers and were oriented along the course of attachment of the trabeculae. In the rarefaction zone, myocytes lay singly or in bundles of 2–3 cells and oriented in different directions, intersecting with each other. The depositing ability of the capsule of the lymph nodes of the stomach in dogs also has local features and is determined by the quantitative and spatial distribution of collagen and elastic fibers, as well as the presence of "reserve" folds in them. The largest number of myocytes and connective tissue fibers were detected in the zone of muscle-connective tissue cords, fewer myocytes and connective tissue fibers were detected in the zone of capsule rarefaction. Most myocytes were found in the capsules of the pancreas-duodenal lymph nodes, and the capsules of the hepatic lymph nodes contained a smaller number of myocytes relative to all regional gastric lymph nodes in dogs.
Sabine Meine: Die Frottola: Musik, Diskurs und Spiel an italienischen Höfen 1500−1530. Turnhout 2013
Authors: Wieczorek Ryszard
Published: January 2025

Recenzja książki Die Frottola: Musik, Diskurs und Spiel an italienischen Höfen1500−1530 Sabine Meine
Identyfikacja ołówkowych dopisków Chopina w egzemplarzach pierwszych wydań z Biblioteki Uniwersyteckiej w Toruniu
Authors: Kamiński Paweł
Published: January 2025

Zachowane liczne egzemplarze dzieł Chopina, z których jego uczniowie korzystali na lekcjach z mistrzem, zawierają wiele ołówkowych naniesień pisanych ręką kompozytora. Dotychczas znane są jednak zbiory egzemplarzy tylko kilkorga spośród ponad setki uczniów Chopina. Pozwala to przypuszczać, że inne tego rodzaju dokumenty czekają jeszcze na odkrycie. Artykuł omawia sześć egzemplarzy pierwszych wydań utworów Chopina z Biblioteki Uniwersyteckiej w Toruniu, zawierających ołówkowe wpisy podobne do znanych z Chopinowskich egzemplarzy lekcyjnych. Przeprowadzono drobiazgową analizę wpisów, zarówno grafiki pisma (cyfr, liter, nut i in.), jak i treści merytorycznej. Kluczowe znaczenie miały porównania z Chopinowskimi naniesieniami w egzemplarzach o niepodważalnej autentyczności, przede wszystkim ze zbiorów należących do Jane Stirling, Camille Dubois czy Ludwiki Jędrzejewicz.
W wyniku analizy ujawniono dokument pierwszorzędnej wagi, jakim okazuje się być egzemplarz lipskiego pierwodruku Kistnera Nokturnów op. 9. W pierwszych dwóch nokturnach zidentyfikowano ponad sto różnego rodzaju wpisów: warianty ornamentalne (w tym kilka zupełnie nieznanych), wzmocnienia oktawowe nut basowych, poprawki błędów druku, łuki i inne oznaczenia artykulacyjne, znaki dynamiczne, pedalizację, palcowania, ukośne krzyże. Większość wykazuje cechy graficzne typowe dla pisma Chopina i dużą zgodność merytoryczną z naniesieniami w znanych egzemplarzach lekcyjnych. Jest to pierwszy znany przypadek Chopinowskich adnotacji w wydaniu niemieckim, wyjątkowa jest także duża liczba i różnorodność wpisów.
Autentyczne naniesienia występują także w dwóch innych zeszytach Nokturnów: w pierwodruku Schlesingera op. 15 i Breitkopfa i Härtla op. 27. Nokturn F op. 15 nr 1 zawiera zapisane w sposób charakterystyczny dla Chopina palcowania, poprawkę błędu druku i szereg drobnych oznaczeń wykonawczych. W Nokturnie Des op. 27 nr 2 wpisy obejmują palcowania i zmiany tekstu wysokościowo-rytmicznego – poprawki błędów lub wcześniejszych wersji oraz jeden wariant. Prawdopodobieństwo autentyczności tych wpisów wydaje się bardzo wysokie.
Najciekawszym wpisem w egzemplarzu pierwodruku niemieckiego Mazurków op. 41 jest dopisany pod tekstem nutowym wariant, przedłużający o 5 taktów zakończenie Mazurka As nr 3. Wariant, opublikowany przez Jana Kleczyńskiego w 1882 r. w redagowanym przez niego wydaniu Mazurków, nie był dotychczas znany w postaci rękopiśmiennej.
Nie wiadomo, kto mógł być właścicielem tych egzemplarzy w czasach Chopina.
„Muzyka w sercu. Serce dla muzyki”. Wpływ Stanisława Węsławskiego na rozwój życia muzycznego w Wilnie okresu dwudziestolecia międzywojennego
Authors: Dąbrowski Przemysław
Published: January 2025

Stanisław Węsławski urodził się w Wilnie dnia 17 września 1896 roku. Był synem Witolda Jana Narcyza i Emilii Franciszki Węsławskich (Saryusz-Bielskiej). W latach młodzieńczych Stanisław uczestniczył w tworzeniu na Wileńszczyźnie skautingu, a następnie harcerstwa. W okresie pierwszej wojny światowej ukończył na uniwersytecie w Moskwie prawo i fakultet muzyczny. Po powrocie do Wilna prowadził kancelarię adwokacką, a swój wolny czas poświęcał także na komponowanie dzieł fortepianowych i pieśni, pod okiem Tadeusza Szeligowskiego. Był też członkiem zwyczajnym wileńskiego Towarzystwa Przyjaciół Nauk i zasiadał w Wydziale Oświatowym Polskiej Macierzy Szkolnej Ziem Wschodnich. Wybrano go również na wiceprezesa Wileńskiego Związku Towarzystw Śpiewaczych i Muzycznych. Ponadto tworzył muzykę do wileńskiej Rozgłośni Polskiego Radia w Wilnie oraz został jej referentem muzycznym, jak i prezesem Zarządu Sekcji Wileńskiej Polskiego Towarzystwa Muzyki Współczesnej (Oddział Wileński). W latach trzydziestych Stanisława Węsławskiego desygnowano również na prezesa Zarządu Centralnego Polskiej Macierzy Szkolnej Ziemi Wileńskiej. Zasiadał, początkowo na stanowisku skarbnika w Prezydium, a następnie w składzie Komisji Rewizyjnej Rady Wileńskich Zrzeszeń Artystycznych – „Erwuza” (RWZA). Działał też w towarzyskim klubie dyskusyjnym „Smorgonia”, był stałym bywalcem „Śród Literackich” oraz członkiem Zarządu Wileńskiego Towarzystwa Filharmonicznego, pełniąc w nim funkcję wiceprezesa. Swoje teksty publikował w „Dzienniku Wileńskim”, „Alma Mater Vilnensis”, „Gazecie Warszawskiej”, „Przeglądzie Muzycznym”, „Muzyce Współczesnej” i „Muzyce”. W okresie drugiej wojny światowej został miedzy innymi pierwszym, konspiracyjnym Prezydentem miasta Wilna. Jego żoną była Jadwiga Zofia z Hryszkiewiczów. Mieli dwóch synów: Jerzego i Michała. Stanisława Węsławskiego rozstrzelano 2 grudnia 1942 roku w Ponarach pod Wilnem.
Iwona Sowińska: Chopin idzie do kina. Kraków 2013
Authors: Wieczorek Sławomir
Published: January 2025

Recenzja książki"Chopin idzie do kina" autorstwa Iwony Sowińskiej
„Koperczaki ” i „Dmuchawce” – odnalezione ludowe kompozycje Witolda Lutosławskiego
Authors: Muras Wioleta
Published: January 2025

Na ponad pół wieku skryły się przed oczami badaczy dwa utwory Witolda Lutosławskiego, które obecnie udało się odnaleźć zarówno w formie partytury jak i nagrania w dwóch archiwach: Paul Sacher Fundation oraz Archiwum Polskiego Radia. Oba dzieła reprezentują użytkową twórczość kompozytora. Koperczaki to jedna z audycji radiowych, która powstała przy współpracy reżysera Jana Koechera prawdopodobnie w 1949 roku. Autorzy opracowali ją w formie wokalno-instrumentalnej suity, wykorzystując ludowe teksty pieśni (lub ich parafrazy) pochodzące z różnych regionów polski. Materiał muzyczny składa się z trzynastu ludowych melodii, zazwyczaj bezpośrednich cytatów, które otrzymały prosty akompaniament zespołu instrumentalnego. Słychać tutaj częste współbrzmienia kwintowe, respektowanie ram tonalności dur-moll, w tym konwencjonalne kontrasty trybów w odcinkach wolnych, prostą rytmikę oraz schematyzm budowy faz i zdań. Audycja ta doskonale wpisała się w propagowaną estetykę socrealizmu, toteż była jedną z najczęściej emitowanych dzieł użytkowych z muzyką Lutosławskiego na radiowej antenie. 
Kolejnym odnalezionym utworem są pochodzące z 1954 roku Dmuchawce, napisane na zamówienie Zespołu Pieśni i Tańca „Skolimów”. To zaledwie pięciominutowe dzieło, przeznaczone na głosy wokalne oraz orkiestrę symfoniczną, nie jest utworem w pełni oryginalnym. Podstawę stanowią dwa tańce (kaziorajka i maryszunka) pochodzące z cyklu Dziesięciu tańców polskich na orkiestrę kameralną z 1953 roku, poprzedzone wstępem i zakończeniem. Obsada orkiestrowa dała kompozytorowi okazję do barwnego, szczególnie w zakresie kolorystyki orkiestrowej, zaaranżowania ludowych tematów. Większe znaczenie mają środki artykulacyjne, ponadto pojawiają się tutaj dysonujące brzmienia, tak typowe dla jego utworów autonomicznych. Oba utwory stanowią historyczne świadectwo twórczości, która z pewnością nigdy by nie powstała, gdyby nie wprowadzono w Polsce socrealistycznej doktryny.
Josquin’s Motet “In amara crucis ara” in the Green Codex of Viadrina
Authors: Odoj Wojciech
Published: January 2025

Manuscript I F 428, located at Wrocław University Library, commonly called The Green Codex of Viadrina, probably copied during the second decade of the sixteenth century, contains complete Mass cycles, single Mass movements, settings of the Magnificat, hymns, motets, and other settings of German texts. Not all of the compositions are attributed, but Martin Staehelin has identified the authorship of many works. Besides the works of such masters of polyphony as Brumel, Compère, Isaac, Senfl, Adam of Fulda, La Rue and Obrecht, the codex contains a tiny motet by Josquin des Prez: In amara crucis ara (fols. 224’–225). This piece is in fact the fourth part of the motet cycle Qui velatus facie fuisti (Officium de passione), published by Petrucci in 1503, from the second motet book titled Motetti de Passione, de Cruce, de Sacramento, de Beata Virgine et huiusmodi B. In MS I F 428, Josquin’s motet was written down after two groups of settings: Officium de Cruce (In nomine Jesu omne genu flectatur caelestium) by Loyset Compère and a polyphonic setting of the Improperia. Some characteristics suggest that these compositions – the two groups of settings plus Josquin’s motet – may have been placed here together because they were considered mutually complementary, all having Good Friday as their subject. In addition, this source fragment is preceded by two blank leaves indicating deliberate separation from the rest of the manuscript, and all the compositions – including Josquin’s motet – are linked by a distinctive ornament attached to the initial letters of the part’s name. Analysis shows that the motet’s text (its symbolic meaning) was probably the main reason why it – and not another part of the cycle Qui velatus facie fuisti – was selected and copied into the codex I F 428. According to the order described earlier, the Improperia are followed by Holy Communion, preceded by a procession of the Holy Sacrament to the altar. In this context, the motet’s words may be read not only symbolically, but also in the literal meaning. It can be assumed that the motet may have been sung during the procession while the hosts were brought to the main altar or while the congregation received the communion.
THE STATE AND TRENDS OF THE MARKET OF GASTRONOMIC SERVICES
Authors:   Lugansk Branch of the Voronezh Institute of the Ministry of Internal Affairs of Russia, Lugansk, Russian Federation, Gabrielova Yuliya V.
Published: January 2025

The article presents the results of research on the state and trends of the market of gastronomic services in dynamics since 2014. The forecast of the dynamics of the market of gastronomic services in the Russian Federation is systematized, calculated and visualized. The trends and trends of the market of gastronomic services in the world and in the Russian Feder-ation are identified and presented. It is stated that the need to study the state and trends of the market of gastronomic services is due to its dynamic development, the impact of the pandemic and changes in consumer preferences. From 2014 to 2023, there were significant changes in the context of the popularization of street food, the introduction of technology and online orders with an emphasis on environmental friendliness and sustainability. The COVID-19 pandemic has caused a shift to online formats, and the post-pandemic period has become a time of adaptation and recovery. The market continues to grow thanks to food tourism and innovations such as cloud kitchens and delivery platforms. It is concluded that studying the processes in the market of gastronomic services makes it possible to understand the main trends, increase the competi-tiveness of market participants and predict the further development of the industry.
INNOVATIVE ACTIVITY OF THE ENTERPRISE FROM THE POINT OF VIEW OF A SYSTEMATIC APPROACH
Authors:   Saint-Petersburg State University of Aerospace Instrumentation, St. Petersburg, Russia, Martynova Yulia A.
Published: January 2025

Innovation activity, being a driver of the company's growth and development, forces business leaders to seek and explore new management methods in order to increase its effectiveness. The article considers the use of a systematic approach in the innovative activity of the enterprise. The concept of the innovation system and its structure are given. The author identifies the elements of the system and outlines their role in innovation. Considering the sys-tem as dynamic made it possible to describe possible states and transitions between them, to identify potential development trajectories.
MANAGEMENT OF FINANCIAL AND ECONOMIC SECURITY OF ENTERPRISE BUSINESS PROCESSES
Authors:   Kadyrov Chechen State University, Grozny, Khamuradov Movsar A. , Grishkov Vadim F. ,   Sobchak International Banking Institute, St. Petersburg, Yagunova Natalia A. ,   Pavlovsky Branch of N. I. Lobachevsky National Research Nizhny Novgorod State University, Bolotkhanov Elimkhazhi B. ,   Grozny State Petroleum Technical University named after Academician M. D. Millionshchikov
Published: January 2025

The article presents a study of the financial and economic security management system of enterprise business processes from the standpoint of the concept of safety-oriented development, resource and process approaches. The resource approach is considered traditional in world practice, where the financial and economic security of an enterprise is considered as a state of effective use of resources to prevent threats and destabilizing factors. Financial and economic security of business processes is ensured by the formation of such properties of busi-ness processes as: financial and economic stability; organizational adaptability; functional effi-ciency; innovative activity; managerial competence. The solution of these problems is impossible without the use of strategic tools for managing the financial and economic security of business processes of enterprise development. Based on the results of the analysis of the characteristics of types of business processes, the criteria for assessing the financial and economic security of enterprise business processes are determined.
TYPOLOGY OF RUSSIAN REGIONS BASED ON EDUCATIONAL MOBILITY OF STUDENTS OF NON-STATE UNIVERSITIES OF VARIOUS FORMS OF EDUCATION
Authors:   Kazan National Research Technological University, Garafiev Ilshat Z.
Published: January 2025

The article analyzes the educational mobility of students of non-state universi-ties in Russia by forms of study: full-time, part-time, correspondence. Using the Gaussian mix-ture method (GMM), clustering of regions by the number of students and interregional mobility coefficients was performed. Key educational centers and regional features were identified. The results emphasize the importance of forms of study in educational migration and regional policy.