bluuebunny/crossref_metadata_2025 huggingface dataset:
Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha–Mutant Endometrial Cancer
Authors: Blanchard Zannel , Rush Craig M. , Arnesen Spencer , Vahrenkamp Jeffery M. , Rodriguez Adriana C. , Jarboe Elke A. , Brown Callie , Chang Matthew E.K. , Flory Mark R. , Mohammed Hisham , Modzelewska Katarzyna , Lum David H. , Gertz Jason
Published: June 2023

Activating estrogen receptor alpha (ER; also known as ESR1) mutations are present in primary endometrial and metastatic breast cancers, promoting estrogen-independent activation of the receptor. Functional characterizations in breast cancer have established unique molecular and phenotypic consequences of the receptor, yet the impact of ER mutations in endometrial cancer has not been fully explored. In this study, we used CRISPR-Cas9 to model the clinically prevalent ER-Y537S mutation and compared results with ER-D538G to discover allele-specific differences between ER mutations in endometrial cancer. We found that constitutive activity of mutant ER resulted in changes in the expression of thousands of genes, stemming from combined alterations to ER binding and chromatin accessibility. The unique gene expression programs resulted in ER-mutant cells developing increased cancer-associated phenotypes, including migration, invasion, anchorage-independent growth, and growth in vivo. To uncover potential treatment strategies, we identified ER-associated proteins via Rapid Immunoprecipitation and Mass Spectrometry of Endogenous Proteins and interrogated two candidates, CDK9 and NCOA3. Inhibition of these regulatory proteins resulted in decreased growth and migration, representing potential novel treatment strategies for ER-mutant endometrial cancer.

Implications:

This study provides insight into mutant ER activity in endometrial cancer and identifies potential therapies for women with ER-mutant endometrial cancer.
Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells
Authors: Jiang Haowen , He Clifford Jiajun , Li Albert M. , He Bo , Li Yang , Zhou Meng-Ning , Ye Jiangbin
Published: June 2023

When the electron transport chain (ETC) function is impaired, cancer cells rely on reductive carboxylation (RC) to convert α-ketoglutarate (αKG) to citrate for macromolecular synthesis, thereby promoting tumor growth. Currently, there is no viable therapy to inhibit RC for cancer treatment. In this study, we demonstrate that the mitochondrial uncoupler treatment effectively inhibits RC in cancer cells. Mitochondrial uncoupler treatment activates the ETC and increases the NAD+/NADH ratio. Using U–13C-glutamine and 1–13C-glutamine tracers, we show that mitochondrial uncoupling accelerates the oxidative tricarboxylic acid (TCA) cycle and blocks RC under hypoxia, in von Hippel-Lindau (VHL) tumor suppressor–deficient kidney cancer cells, or under anchorage-independent growth condition. Together, these data demonstrate that mitochondrial uncoupling redirects α-KG from RC back to the oxidative TCA cycle, highlighting that the NAD+/NADH ratio is one key switch that determines the metabolic fate of α-KG. Inhibiting RC could be a key mechanism by which mitochondrial uncouplers inhibit tumor growth.

Implications:

Mitochondrial uncoupling is a novel strategy to target RC in cancer.
Supplementary Table S3 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: June 2023

Supplementary Table S3 lists the primers used for qPCR
Supplementary Table S1 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: June 2023

Supplementary Table S1 details clinical data of PDAC patients
Supplementary Table 4 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: June 2023

Quality control and filtering of snRNA-seq data.
Supplementary Figures 1-27 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: June 2023

Figures describing hindbrain vs ganglionic eminence targeting strategies, each of the 16 models generated and validation that they expressed the introduced mutations, survival of GE vs CTX-electroporated embryos, and cell viability data shown in bar graph format.
Data from Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hurthle cell carcinoma of the thyroid
Authors: Frank Anderson R. , Li Vicky , Shelton Spencer D. , Kim Jiwoong , Stott Gordon M. , Neckers Leonard M. , Xie Yang , Williams Noelle S. , Mishra Prashant , McFadden David G.
Published: June 2023

Abstract
A metabolic hallmark of cancer identified by Warburg is the increased consumption of glucose and secretion of lactate, even in the presence of oxygen. Although many tumors exhibit increased glycolytic activity, most forms of cancer rely on mitochondrial respiration for tumor growth. We report here that Hurthle cell carcinoma of the thyroid (HTC) models harboring mitochondrial DNA-encoded defects in complex I of the mitochondrial electron transport chain exhibit impaired respiration and alterations in glucose metabolism. CRISPR-Cas9 pooled screening identified glycolytic enzymes as selectively essential in complex I-mutant HTC cells. We demonstrate in cultured cells and a PDX model that small molecule inhibitors of lactate dehydrogenase selectively induce an ATP crisis and cell death in HTC. This work demonstrates that complex I loss exposes fermentation as a therapeutic target in HTC and has implications for other tumors bearing mutations that irreversibly damage mitochondrial respiration.
Data from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: June 2023

Abstract
Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by clonal mutations in histone genes. They often harbor a range of additional genetic alterations that correlate with different ages, anatomic locations, and tumor subtypes. We developed models representing 16 pHGG subtypes driven by different combinations of alterations targeted to specific brain regions. Tumors developed with varying latencies and cell lines derived from these models engrafted in syngeneic, immunocompetent mice with high penetrance. Targeted drug screening revealed unexpected selective vulnerabilities—H3.3G34R/PDGFRAC235Y to FGFR inhibition, H3.3K27M/PDGFRAWT to PDGFRA inhibition, and H3.3K27M/PDGFRAWT and H3.3K27M/PPM1DΔC/PIK3CAE545K to combined inhibition of MEK and PIK3CA. Moreover, H3.3K27M tumors with PIK3CA, NF1, and FGFR1 mutations were more invasive and harbored distinct additional phenotypes, such as exophytic spread, cranial nerve invasion, and spinal dissemination. Collectively, these models reveal that different partner alterations produce distinct effects on pHGG cellular composition, latency, invasiveness, and treatment sensitivity.
Significance:
Histone-mutant pediatric gliomas are a highly heterogeneous tumor entity. Different histone mutations correlate with different ages of onset, survival outcomes, brain regions, and partner alterations. We have developed models of histone-mutant gliomas that reflect this anatomic and genetic heterogeneity and provide evidence of subtype-specific biology and therapeutic targeting.
Table S5 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Supplementary Table S5 shows the canonical marker genes, differentially expressed genes (DEGs), and gene modules scores used to annotate the T-cell UMAP clusters
Supplementary Figure 3 from NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Authors: Cecchini Michael , Walther Zenta , Wei Wei , Hafez Navid , Pilat Mary Jo , Boerner Scott A. , Durecki Diane E. , Eder Joseph P. , Schalper Kurt A. , Chen Alice P. , LoRusso Patricia
Published: June 2023

Progression free survival and overall survival curves.
Supplementary Figure 2 from NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Authors: Cecchini Michael , Walther Zenta , Wei Wei , Hafez Navid , Pilat Mary Jo , Boerner Scott A. , Durecki Diane E. , Eder Joseph P. , Schalper Kurt A. , Chen Alice P. , LoRusso Patricia
Published: June 2023

Waterfall plot for best response by RECIST version 1.1.
Figure S10 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S10 shows correlation of overlapping clonotypes between the tumor and pre-REP TILs.
Data from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Abstract
The successful use of expanded tumor-infiltrating lymphocytes (TILs) in adoptive TIL therapies has been reported, but the effects of the TIL expansion, immunophenotype, function, and T-cell receptor (TCR) repertoire of the infused products relative to the tumor microenvironment (TME) are not well understood. In this study, we analyzed the tumor samples (n=58) from treatment-naïve RCC patients, “pre-rapidly expanded” TILs (pre-REP TIL, n=15) and “rapidly expanded” TILs (REP TILs, n=25) according to a clinical-grade TIL production protocol, with scRNA+TCRab-seq, TCRb-seq, and flow cytometry. REP TILs encompassed a greater abundance of CD4+ than CD8+ T-cells, with increased LAG-3 and low PD-1 expressions in both CD4+ and CD8+ T-cell compartments compared to the pre-REP TIL and tumor T-cells. The REP protocol preferentially expanded small clones of the CD4+ phenotype (CD4, IL7R, KLRB1) in the TME, indicating that the largest exhausted T-cell clones in the tumor do not expand during the expansion protocol. Additionally, by generating a catalog of RCC-associated TCR motifs from >1000 scRNA+TCRab-seq and TCRb-seq RCC, healthy and other cancer sample cohorts, we quantified the RCC-associated TCRs from the expansion protocol. Unlike the low-remaining amount of anti-viral TCRs throughout the expansion, the quantity of the RCC-associated TCRs was high in the tumors and pre-REP TILs but decreased in the REP TILs. Our results provide an in-depth understanding of the origin, phenotype, and TCR specificity of RCC TIL products, paving the way for a more rationalized production of TILs.
Immunologic Characterization and T cell Receptor Repertoires of Expanded Tumor-infiltrating Lymphocytes in Patients with Renal Cell Carcinoma
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

The successful use of expanded tumor-infiltrating lymphocytes (TIL) in adoptive TIL therapies has been reported, but the effects of the TIL expansion, immunophenotype, function, and T cell receptor (TCR) repertoire of the infused products relative to the tumor microenvironment (TME) are not well understood. In this study, we analyzed the tumor samples (n = 58) from treatment-naïve patients with renal cell carcinoma (RCC), “pre-rapidly expanded” TILs (pre-REP TIL, n = 15) and “rapidly expanded” TILs (REP TIL, n = 25) according to a clinical-grade TIL production protocol, with single-cell RNA (scRNA)+TCRαβ-seq (TCRαβ sequencing), TCRβ-sequencing (TCRβ-seq), and flow cytometry. REP TILs encompassed a greater abundance of CD4+ than CD8+ T cells, with increased LAG-3 and low PD-1 expressions in both CD4+ and CD8+ T cell compartments compared with the pre-REP TIL and tumor T cells. The REP protocol preferentially expanded small clones of the CD4+ phenotype (CD4, IL7R, KLRB1) in the TME, indicating that the largest exhausted T cell clones in the tumor do not expand during the expansion protocol. In addition, by generating a catalog of RCC-associated TCR motifs from >1,000 scRNA+TCRαβ-seq and TCRβ-seq RCC, healthy and other cancer sample cohorts, we quantified the RCC-associated TCRs from the expansion protocol. Unlike the low-remaining amount of anti-viral TCRs throughout the expansion, the quantity of the RCC-associated TCRs was high in the tumors and pre-REP TILs but decreased in the REP TILs. Our results provide an in-depth understanding of the origin, phenotype, and TCR specificity of RCC TIL products, paving the way for a more rationalized production of TILs.

Significance:

TILs are a heterogenous group of immune cells that recognize and attack the tumor, thus are utilized in various clinical trials. In our study, we explored the TILs in patients with kidney cancer by expanding the TILs using a clinical-grade protocol, as well as observed their characteristics and ability to recognize the tumor using in-depth experimental and computational tools.
International Newborn Screening Practices for the Early Detection of Congenital Adrenal Hyperplasia
Authors: Conlon Tracey A. , Hawkes Colin P. , Brady Jennifer J. , Loeber J. Gerard , Murphy Nuala
Published: June 2023

Introduction: Newborn screening (NBS) programmes vary internationally in their approach to screening. Guidelines for congenital adrenal hyperplasia (CAH) screening recommend the use of two-tier testing and gestational age cutoffs to minimise false-positive results. The aims of this study were to describe (1) the approaches; (2) protocols used; and (3) available outcomes for CAH screening internationally. Methods: All members of the International Society for Neonatal Screening were asked to describe their CAH NBS protocols, with an emphasis on the use of second-tier testing, 17-hydroxyprogesterone (17OHP) cutoffs, and gestational age and birth weight adjustments. If available, screening outcomes were requested. Results: Representatives from 23 screening programmes provided data. Most (n = 14; 61%) recommend sampling at 48–72 h of life. Fourteen (61%) use single-tier testing and 9 have a two-tier testing protocol. Gestational age cutoffs are used in 10 programmes, birth weight cutoffs in 3, and a combination of both in 9. One programme does not use either method of adjusting 17OHP cutoffs. Case definition of a positive test and the response to a positive test differed between programmes. Conclusions: We have demonstrated significant variation across all aspects of NBS for CAH, including timing, the use of single versus two-tier testing and cutoff interpretation. Collaboration between international screening programmes and implementation of new techniques to improve screen efficacy will facilitate ongoing expansion and quality improvement in CAH NBS.
Quantification of Diffusion Magnetic Resonance Imaging for Prognostic Prediction of Neonatal Hypoxic-Ischemic Encephalopathy
Authors: Onda Kengo , Chavez-Valdez Raul , Graham Ernest M. , Everett Allen D. , Northington Frances J. , Oishi Kenichi
Published: June 2023

Neonatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of acquired neonatal brain injury with the risk of developing serious neurological sequelae and death. An accurate and robust prediction of short- and long-term outcomes may provide clinicians and families with fundamental evidence for their decision-making, the design of treatment strategies, and the discussion of developmental intervention plans after discharge. Diffusion tensor imaging (DTI) is one of the most powerful neuroimaging tools with which to predict the prognosis of neonatal HIE by providing microscopic features that cannot be assessed by conventional magnetic resonance imaging (MRI). DTI provides various scalar measures that represent the properties of the tissue, such as fractional anisotropy (FA) and mean diffusivity (MD). Since the characteristics of the diffusion of water molecules represented by these measures are affected by the microscopic cellular and extracellular environment, such as the orientation of structural components and cell density, they are often used to study the normal developmental trajectory of the brain and as indicators of various tissue damage, including HIE-related pathologies, such as cytotoxic edema, vascular edema, inflammation, cell death, and Wallerian degeneration. Previous studies have demonstrated widespread alteration in DTI measurements in severe cases of HIE and more localized changes in neonates with mild-to-moderate HIE. In an attempt to establish cutoff values to predict the occurrence of neurological sequelae, MD and FA measurements in the corpus callosum, thalamus, basal ganglia, corticospinal tract, and frontal white matter have proven to have an excellent ability to predict severe neurological outcomes. In addition, a recent study has suggested that a data-driven, unbiased approach using machine learning techniques on features obtained from whole-brain image quantification may accurately predict the prognosis of HIE, including for mild-to-moderate cases. Further efforts are needed to overcome current challenges, such as MRI infrastructure, diffusion modeling methods, and data harmonization for clinical application. In addition, external validation of predictive models is essential for clinical application of DTI to prognostication.
Modeling and bifurcation analysis of an intraguild predation system
Authors: Tamba Tua A.
Published: June 2023

This paper proposes a mathematical model of an asymmetric intraguild (IG) predation system with an exclusive alternative resource. In particular, this paper analyzes the effects that the exclusive alternative resource has on the consumption/predation behaviors of both the IG predator and IG prey species in the system. The results presented on this paper show that, if the IG predator is less competitive in consumption and less efficient in conversion of the shared resource than that of the IG prey, then there exists a lower bound on the value of the predation rate parameter that should be maintained by IG predator species to ensure its survival and co-existence in the system.
Electrocardiogram signals classification using random forest method for web-based smart healthcare
Authors: Sari Juni Nurma , Madona Putri , Kusryanto Hari , Zain Muhammad Mahrus , Valzon May
Published: June 2023

Coronary heart is the highest cause of death in Indonesia reaching 26%. Therefore, to prevent the high mortality rate of coronary heart disease (CHD), early detection of CHD can be carried out. One way is to examine the electrocardiogram/electrocardiograph (ECG) recording. ECG hardware has been made in previous studies to record ECG signals. ECG research is an important study because it can detect cardiovascular disease. Cardiovascular diseases can be classified as arrhythmic diseases. Arrhythmia is a disorder that occurs in the heart rhythm. The method used to recognize and classify ECG signal patterns is the R-R interval (RRI) method. In this study, the ECG signal is classified as normal and abnormal. Abnormal means that a person has a heart rhythm disorder. The classification method used is random forest. The advantage of the random forest classifier is that it can handle noise and missing values and can handle large amounts of data. The accuracy of the ECG signal classification using the Random forest method is 96%. The contribution of this research is that early detection of heart rhythm disorders using an ECG can be monitored through the smart healthcare web.
New record of the sphingid moth Acherontia styx Westwood, its parasitoid Trichogramma achaeae in Jasmine Jasminum sambac L., and its bioecology
Authors: I. Merlin K. Davidson
Published: June 2023

The sphingid moth larvae are voracious defoliators of several crops. The present study was conducted to investigate damage of Acherontia styx on Jasmine, their seasonal incidence, and bioecology. Larval instars fed on jasmine leaves and flowers, with the highest defoliation being 35% and highest flower damage 47% during September. The lifecycle consisted of egg, five larval instars, pupal, and adult stages. The eggs were pearly white in colour and emerged larvae were cylindrical with a prominent anal horn. In subsequent moults the larvae continued to feed and become larger until they turned a reddish colour and ceased feeding prior to pupating in the soil. Adult moths were robust and swift fliers. The total life cycle from egg to adult was 56 days for males and 59 days for females. Trichogramma achaeae Nagaraja & Nagarkatti was noticed and documented as a potential egg parasitoid of the sphingid moth, a new record. A natural parasitization of eggs was noticed under field conditions, with changed colour of eggs to deep black from which a tiny parasitic wasp emerged, identified as T. achaea.
Troglobitic invertebrates: improving the knowledge on the Brazilian subterranean biodiversity through an interactive multi-entry key
Authors: PARIZOTTO DANIELE R. , PIRES AMANDA CIPRANDI , MISE KLEBER MAKOTO , FERREIRA RODRIGO LOPES
Published: June 2023

Troglobitic species are those organisms restricted to caves that frequently present unique morphological features related to these environments. In order to study its ecology, evolution and biogeography, it is first required to properly recognize them. However, especially in Brazil, the basic knowledge is still incipient, with few taxonomic studies such as identification keys for this group of organisms. In addition, since the troglobitic species belong to different taxonomic groups, the information to properly recognize them is often sparse and difficult to access. Considering this, an interactive multi entry taxonomic key available online is an interesting approach, as it makes identifications easier. This study aims to construct a multi-access interactive identification key to the troglobitic invertebrates of Brazil, using morphological characters obtained from literature and direct observations of specimens. The key was made in Lucid version 3.3, containing figures of most characters. It comprises seventy-eight species of troglobitic invertebrates that occur in Brazil, forming a matrix of 231 morphological characters and more than 200 images to support identification. The key is freely available online on lucid central (http://keys.lucidcentral.org/keys/v3/troglobitic_invertebrates/troglobitic_invertebrates.html). Since Brazilian laws regarding cave conservation has change in 2008, allowing even the destruction of caves, this multi-access identification key is step to reduce the existing taxonomic impediment and also an important tool for identification of troglobites, especially for non-specialists.
New taxa and notes on crickets of the subfamily Landrevinae (Orthoptera: Gryllidae) from Brunei Darussalam, Borneo
Authors: TAN MING KAI , WAHAB RODZAY BIN HAJI ABDUL
Published: June 2023

New taxa from the subfamily Landrevinae (Orthoptera: Gryllidae) are expected despite recent work on its taxonomy. Here, two more new species from Brunei Darussalam, Borneo are described: Duolandrevus (Eulandrevus) kawataredoki sp. nov. and Endodrelanva nympha sp. nov. The male calling song of D. (E.) kawataredoki sp. nov. is also described. We report the occurrence of a Duolandrevus (Bejorama) from Brunei close to (nr.) luzonensis Otte, 1988. We also document from Brunei a case of parasitic wasp from the genus Liris (Hymenoptera: Crabronidae: Larrini) hunting a Landrevinae.
Revision of the Agrilus wittemani species–group (Coleoptera: Buprestidae: Agrilini) with description of three new species from India and Myanmar
Authors: JENDEK EDUARD , NAKLÁDAL OTO
Published: June 2023

The newly defined Agrilus wittemani species–group comprising six species from South and Southeast Asia is revised based on the examination of type specimens. A key to species is provided and complemented with illustrations of habitus and genitalia. The following three new species are described: Agrilus amplinotus sp. nov.; A. stigmula sp. nov.; A. stigmulifer sp. nov.
Anomalous Northward Energy Transport due to Anthropogenic Aerosols during the Twentieth Century
Authors: Needham Michael R. , Randall David A.
Published: June 2023

In the tropics, the absorbed solar radiation is larger than the outgoing longwave radiation, while the opposite is true at high latitudes. This basic fact implies a poleward energy transport (PET) in both hemispheres, which is accomplished by the atmosphere and oceans. The magnitude of PET is determined by the top of atmosphere gradient in the net radiation flux, and small changes to this quantity must change the total PET in the absence of changes in heat uptake. We analyze a large ensemble of 50 historic climate simulations from the CESM LENS2 project and find a significant PET anomaly in the latter half of the twentieth century. The temporal evolution of this anomaly—with a rapid increase after 1950, a peak near 1975, and a rapid decrease in the 1990s—mirrors the historic trend of sulfur dioxide (SO2, a significant aerosol predecessor) emissions from Europe and North America. This anomaly also appears in an analysis of the PET calculated from ERA5 reanalyses and from the CESM2 Single Forcing Large Ensemble. Consistent with previous studies, we find that historic SO2 emissions from Europe and North America brightened clouds, which reflected additional solar radiation back to space in the midlatitudes: this shortwave anomaly increased the meridional gradient in the net TOA radiation flux and induced an anomalous northward energy transport. Finally, our results suggest that cryosphere processes become an additional important factor in setting the PET anomaly during the first years of the twenty-first century by contributing to the difference in absorbed solar radiation between hemispheres alongside cloud radiative effects.

significance statement

In this study, we analyze a large group of climate model simulations from 1850 to 2014 and find that this historical pollution changed the way that heat was transported from the tropics to Earth’s poles. We also find this change in heat transport when we analyzed an atmospheric reanalysis, which is a historical dataset that combines many meteorological observations into a best estimate of the past climate state. This extra reflection of sunlight from polluted clouds cooled the Northern Hemisphere, and we hypothesize that this cooling caused more heat transport out of the tropics. Last, we find that similar pollution emitted from China and India in more recent decades has not led to a change in Earth’s heat transport because of counteracting changes in snow and ice in the Northern Hemisphere.
Uncanny Teletherapy: Working with Extimacy
Authors: Strosberg Benjamin B. , Hook Derek , Leadem Sean
Published: June 2023

Responses to the question of teletherapy have multiplied over the past decades, yet many therapists are grappling with the challenges and opportunities of teletherapy for the first time in the wake of the Covid-19 pandemic. For many clinicians, teletherapy was, at least initially, unfamiliar and unsettling. Much of the literature construes teletherapy as a degradation of an original—incapable of providing the intimacy achieved and maintained in two-bodies-in-a-room therapy—or as a good enough simulation. Both positions risk enshrining the consulting room as offering an unmediated scene of therapy. An alternative approach to the strangeness, distance, and mediations so prominent in the transition to teletherapy takes up a qualified sense of Freud’s concept of the uncanny: the “minimal uncanny” and its reformulation in Lacanian theory as extimacy, a lens through which to explore intimacy and bodily proximity in the transition to teletherapy. Through the logic of extimacy, a theoretical view emerges that approaches teletherapy not as a poor substitute for real therapy, or a good enough substitute, but as an exemplary case of the therapeutic encounter.
An Empirical Assessment of the European Commission’s Cartel Prosecutions, 2010–2019
Authors: Veljanovski Cento
Published: June 2023

This is a quantitative analysis of the European Commission’s cartel decisions in the 2010–2019 decade. It assesses the way the Commission’s 2006 guidelines on fines were applied in practice and the operation of the leniency and settlement procedures. It also provides an overview of the types of cartels prosecuted, how they were detected, and how long the Commission took to investigate a cartel. It looks at rends in the Commission’s enforcement activity and assesses some frequently made claims such as whether recidivism is rife; whether the Commission’s leniency program is excessively generous and disproportionately benefits larger, more culpable firms; how much the settlements procedure reduces the length of the Commission’s investigations; and why the Commission takes so long to conclude its investigations.
Explaining Variability in Trajectories of Self-Control Using Growth-Curve Modeling: The Effects of Parental Socialization and Victimization
Authors: You Myunghee , Stults Brian J.
Published: June 2023

Many in recent years have found a lack of stability in self-control throughout childhood. We test whether this finding also applies to a non-US sample using six waves of data from a longitudinal survey of South Korean youth ages 13 to 18. We then expand on prior studies by testing whether trajectories of self-control are affected by parental socialization and victimization. Using hybrid growth-curve models, we find a “J-curve” pattern of self-control trajectory, whereby self-control declines in the early years, but then increases in subsequent years. Moreover, parental socialization influences variability of absolute self-control, while victimization affects relative ranking of self-control. We suggest that studies pay attention to the dynamic variability of self-control trajectories over the life course.
Measuring Unipolar Traits With Continuous Response Items: Some Methodological and Substantive Developments
Authors: Ferrando Pere J. , Morales-Vives Fabia , Hernández-Dorado Ana
Published: June 2023

In recent years, some models for binary and graded format responses have been proposed to assess unipolar variables or “quasi-traits.” These studies have mainly focused on clinical variables that have traditionally been treated as bipolar traits. In the present study, we have made a proposal for unipolar traits measured with continuous response items. The proposed log-logistic continuous unipolar model (LL-C) is remarkably simple and is more similar to the original binary formulation than the graded extensions, which is an advantage. Furthermore, considering that irrational, extreme, or polarizing beliefs could be another domain of unipolar variables, we have applied this proposal to an empirical example of superstitious beliefs. The results suggest that, in certain cases, the standard linear model can be a good approximation to the LL-C model in terms of parameter estimation and goodness of fit, but not trait estimates and their accuracy. The results also show the importance of considering the unipolar nature of this kind of trait when predicting criterion variables, since the validity results were clearly different.
Prediction of Electricity Trade Partners Based on the Network Theory: The West Asia Community
Authors: Mirtajadini Leila , Bakhsh Shamsollah Shirin , Mousavi Mir Hossein , Heydari Kioumars , Yousefvand Saman
Published: June 2023

This study aims to predict electricity cross-border trade partners based on the network theory and to investigate the position and importance of West Asia community in the global electricity trade network. For this purpose, the global network is constructed to examine the role of each node in the network for the time period of 2010–2018. Different communities are identified to proceed with the network analysis. The innovative analysis is link prediction to forecast missing links from the network. The results suggest more interconnectedness among community members, especially Iran, Turkey and Russia, which are the prominent nodes in the community. The link prediction outcomes offer the most probable missing links from the community and lead us to select the common neighbour approach as the most efficient method.

JEL Codes: D85, Q27
How Do Drivers Perceive Risks During Automated Driving Scenarios? An fNIRS Neuroimaging Study
Authors: Perello-March Jaume , Burns Christopher G. , Woodman Roger , Birrell Stewart , Elliott Mark T.
Published: June 2023

Objective

Using brain haemodynamic responses to measure perceived risk from traffic complexity during automated driving.

Background

Although well-established during manual driving, the effects of driver risk perception during automated driving remain unknown. The use of fNIRS in this paper for assessing drivers’ states posits it could become a novel method for measuring risk perception.

Methods

Twenty-three volunteers participated in an empirical driving simulator experiment with automated driving capability. Driving conditions involved suburban and urban scenarios with varying levels of traffic complexity, culminating in an unexpected hazardous event. Perceived risk was measured via fNIRS within the prefrontal cortical haemoglobin oxygenation and from self-reports.

Results

Prefrontal cortical haemoglobin oxygenation levels significantly increased, following self-reported perceived risk and traffic complexity, particularly during the hazardous scenario.

Conclusion

This paper has demonstrated that fNIRS is a valuable research tool for measuring variations in perceived risk from traffic complexity during highly automated driving. Even though the responsibility over the driving task is delegated to the automated system and dispositional trust is high, drivers perceive moderate risk when traffic complexity builds up gradually, reflected in a corresponding significant increase in blood oxygenation levels, with both subjective (self-reports) and objective (fNIRS) increasing further during the hazardous scenario.

Application

Little is known regarding the effects of drivers’ risk perception with automated driving. Building upon our experimental findings, future work can use fNIRS to investigate the mental processes for risk assessment and the effects of perceived risk on driving behaviours to promote the safe adoption of automated driving technology.
Tooth root crack detection of planet gear in industrial robot RV reducer
Authors: Yan Yunhai , Guo Yu , Liu Xiaoqin
Published: June 2023

The windowed synchronous averaging (WSA) is widely utilized for planetary structures. However, it cannot be applied for the fault detection of the planetary structure in the industrial robot rotate vector (RV) reducer. The robot usually works within a specified angle range, which causes the RV reducer rotates incompletely. To address this issue, an angle compensation local synchronous fitting scheme is proposed. To detect the localized planet gear fault in the RV reducer, the observed vibration is equi-angle resampled. And the synchronous interference contained in the resampled vibration is constructed and removed according to the angle compensation strategy. The residual data is used to construct the synthetic vibration of the planet gear. Then, the fault feature of the planet gear can be detected. Experiments on the RV reducer test rig under the robot running conditions support the effectiveness of the proposed scheme positively.
A modified artificial neural network to predict the tribological properties of Al-SiC nanocomposites fabricated by accumulative roll bonding process
Authors: Najjar IMR , Sadoun AM , Ibrahim A , Ahmadian H , Fathy A
Published: June 2023

This work highlights the major influence of SiC concentration and plastic deformation on boosting wear rates of aluminum composites supplemented with SiC particles comprising varied volume fractions (0–4%). It also shows how a basic neural network model augmented with a particle swarm optimizer can forecast wear rates and coefficients of friction for complicated composites. According to the experimental findings, increasing the quantity of accumulative roll bonding (ARB) enhances SiC particle dispersion homogeneity. Increasing the number of cycles and introducing additional SiC particles helped to reduce the wear rate and increase the friction coefficient. After nine ARB cycles, the Al-4 wt.% SiC nanocomposite had the best improvement in both wear rate and friction coefficient. The same sample was also used in efforts to enhance the characteristics of hardness, and it was selected as having the highest level of hardness, which has grown by 139%. All of the generated composites evaluated at four different wear loads were able to be predicted by the proposed model with great accuracy, with determination coefficient R2 values of 0.9768 and 0.9869 for the frictional coefficient and wear rates, respectively.
The subversive power of calling: The Girls’ Auxiliary and Baptist women in ministry
Authors: Hoyle Lydia Huffman
Published: June 2023

In the second half of the twentieth century, a group called the Girls’ Auxiliary (GA) became influential in the lives of many Southern Baptist girls and women. Through weekly meetings, annual camps, fund-raising, and individual mission activities, girls learned about how they could make a difference in the world through missions. In Baptist life, mission was the central work of the church. Alongside the Women’s Missionary Union (WMU), which sponsored and led the girls, the GAs brought attention to the mission cause and helped in collecting funds to support it. In annual “coronations,” girls were honored and crowned as mission queens in the Baptist kingdom. They often even spoke in these church-wide gatherings. This article explores the impact of the GA program on women who ultimately became Baptist ministers. Based on a survey of over 200 contemporary women ministers, the program did clearly impact a significant number of women who reported that the GA program gave them a greater sense of purpose, helped them to understand their vocational calling, and helped them see themselves as church leaders. Ultimately, the GA program became less influential and has now disappeared in many congregations.
Koινωνία: Fellowship with or participation in the Spirit? Revisiting 2 Corinthians 13:13
Authors: Green Colin Antony
Published: June 2023

The notion that, in the Christian Scriptures, the term κοινωνία (koinōnia) can mean “fellowship” has been challenged on philological grounds. Scholars argue that, in ancient non-Christian sources, meanings such as fellowship with fellow humans and with God are absent and that mundane meanings of participation and alliances are to be preferred. Discussion of this subject has suffered from a dichotomy between whether usage in classical sources trumps Christian theology in reading texts. Attention to Philo and revisiting philological patterns in Scripture suggest, however, the word had evolved to mean fellowship in the hands of Paul.
The influence of social status and identity in a struggle for matriarchal power: Genesis 16:1–15
Authors: Aiken-Morgan Adrienne T.
Published: June 2023

The Genesis 16 narrative is a story about power afforded to individuals based on social status and identity. As such, modern readings of Gen 16 (and Gen 21) unsurprisingly informed the genesis of womanist theology. In her seminal text, Sisters in the Wilderness: The Challenge of Womanist God-Talk, Delores Williams offers a theological perspective centering the social and historical experiences of Black women in biblical and theological interpretation by examining Hagar’s story. This article takes a fresh look at Gen 16:1–15 by examining the influence of social status and identity in a struggle for matriarchal power between Hagar and Sarai. It does this by understanding the sociocultural context of the ancient Near East, as well as English translation choices that serve as barriers to interpretation for a modern audience. Modern Bible readers draw parallels between this text and modern struggles against oppressive power systems and are reminded of God’s sovereignty and action in favor of the oppressed.
The Impact of Narrative Reviews on Patient E-doctor Choice in Online Health Communities
Authors: Zhang Min , Sun Yuxuan , Zhao Xiaosong , Wang Lingmei , Xiong Jingjing
Published: June 2023

As online health communities (OHCs) continue to proliferate, narrative reviews on doctors have become a vital reference source for patients when choosing online health services. However, the potential value of subjective information reflecting patient experiences in OHCs has not been fully explored. The present study seeks to investigate the impact of narrative reviews on patients’ selection of e-doctors and the extent to which such reviews are moderated by doctors’ specialties. This paper collected data from 747 doctors and 105 032 reviews from WeDoctor, one of China’s most popular OHCs, in 2019. We employed Latent Dirichlet Allocation topic modeling to extract 3 topics and analyzed their effects on patient e-doctor choice using a multiple regression method. Our findings indicate that Topic 1, clinical skills and effects, had a positive impact on patient choice in OHCs ( β1 = .243, P < .001), as did Topic 2, service attitude and trust ( β2 = .130, P < .05). However, the impact of Topic 3, convenience, did not show a significant effect in this study. Moreover, our results suggest that the specialty of Internal Medicine can positively moderate the relationship between Topic 1 (clinical skills and effects) and patient e-doctor choice ( β9 = .087, P < .05). Based on the findings of this study, e-doctors are encouraged to enhance their technical competence to improve treatment effectiveness and adjust their communication methods to increase patient trust and sense of security. OHC platform managers should accurately understand the key factors that influence patient choice and take measures to improve their service quality accordingly.
Japan’s retreat to the metaverse
Authors: Roquet Paul
Published: June 2023

As in much of the world, interest in Japan surrounding the ‘metaverse’ quickly arose in response to Facebook’s embrace of the term and rebranding to Meta in October 2021. While Meta’s own vision focused on blending virtual spaces with existing office environments, prominent Japanese metaverse approaches focused instead on the production of alternate worlds that could more fully substitute for this one. This essay turns to trade paperbacks from metaverse developers and proponents released in Japan in the wake of Facebook’s rebranding, exploring the emphasis on physical and social withdrawal that characterizes these metaverse appeals. Examining the conservative ‘otaku’ politics that underwrite this retreat to more comfortable, more controllable forms of media immersion, I offer a critical examination of these Japanese proposals to outsource the space of everyday social interaction to for-profit American technology platforms.
Share with care: negotiating children’s health and safety in sharenting practices
Authors: Tartari Morena , Lavorgna Anita , Ugwudike Pamela
Published: June 2023

Sharenting – a new term emerged over the past 10 years – refers to the practice of sharing textual and audiovisual contents concerning children online by their parents or guardians, potentially impacting the construction of children’s digital identity before they can reach the age of consent. Based on a passive virtual ethnography carried out comparatively in Italian-speaking and English-speaking virtual communities focusing on children’s wellbeing and health, this paper offers an empirical contribution to the study of sharenting. While contributing to the wider debates on the practices and discourses about sharing in digital media, this paper provides an analysis of how online and offline parenting cultures affect sharenting practices; how the consequences of sharenting are addressed in online communities; and how the privacy vs openness tension about sharing contents is negotiated by parents with regards to their own and children needs even in terms of digital security.
Investigating the reviewer assignment problem: A systematic literature review
Authors: Ribeiro Ana Carolina , Sizo Amanda , Reis Luís Paulo
Published: June 2023

The assignment of appropriate reviewers to academic articles, known as the reviewer assignment problem (RAP), has become a crucial issue in academia. While there has been much research on RAP, there has not yet been a systematic literature review (SLR) examining the various approaches, techniques, algorithms and discoveries related to this topic. To conduct the SLR, we identified and evaluated relevant articles from four databases using defined inclusion and exclusion criteria. We analysed the selected articles and extracted information, and assessed their quality. Our review identified 67 articles on RAP published in conferences and journals up to mid-2022. As one of the main challenges in RAP is acquiring open data, we have studied the data sources used by researchers and found that most studies use real data from conferences, bibliographic databases and online academic search engines. RAP is divided into two main phases: (1) finding/recommending expert reviewers and (2) assigning reviewers to submitted manuscripts. In Phase 1, we have identified that decision support systems, recommendation systems, and machine learning-oriented approaches are more commonly used due to better results. In Phase 2, heuristics and metaheuristics are the approaches that present better results and are consequently more commonly used by researchers. Based on the analysed studies, we have identified potential areas for future research that could lead to improved results. Specifically, we suggest exploring the application of deep neural networks for calculating the degree of correspondence and using the Boolean satisfiability problem to optimise the attribution process.