bluuebunny/crossref_metadata_2025 huggingface dataset:
Секторный многооборотный времяпролетный масс-анализатор с пакетами ионов, удлиненными в направлении дрейфа
Authors: М.И. Явор , Т.В. Помозов , А.Н. Веренчиков
Published: December 2024

Предложена ионно-оптическая схема секторного многооборотного времяпролетного масс-анализатора со спиральными траекториями и ортогональным вводом ионных пакетов, удлиненных в направлении дрейфа ионов. В анализаторе использованы дефлекторы, формирующие максимальное число оборотов ионов при фиксированной длине дрейфа. Разработана оригинальная схема компенсации наклона временных фронтов пакетов ионов, образующегося при развороте ионов в направлении дрейфа после прохождения полной длины анализатора.
Краевые матрицы магнитного сектора статического масс-спектрометра
Authors: В.Д. Саченко , А.С. Антонов
Published: December 2024

Элементы 1-го порядка входной и выходной краевых матриц перехода магнитного сектора выведены из закона сохранения обобщенного импульса ионов в магнитном поле. Показано, что вид краевой матрицы не однозначен и зависит от эффективной модели, в рамках которой учитывается снос траекторий в краевом поле. Сравнение с аналогичными данными, найденными традиционным методом, а именно разложением компонент краевого поля и траекторных уравнений в асимптотические ряды и интегрированием порядковых приближений, показало, что, если область идеального поля эффективного магнитного сектора ограничена границами Герцога, то полученные элементы краевой матрицы 1-го порядка значительно отличаются от опубликованных данных.
Ион-реагент NH4+(H2O). Механизм повышения специфичности приборов на основе спектрометрии ионной подвижности для обнаружения токсичных веществ в присутствии алканов
Authors: А.В. Лебедев , С.С. Колбинев
Published: December 2024

В приборах для обнаружения токсичных веществ на основе спектрометрии ионной подвижности с химической ионизацией при атмосферном давлении в качестве иона-реагента все чаще используют гидратированный аммоний NH4+(H2O)n вместо обычно применяемого гидратированного гидроксония H3O+(H2O)n и ионов, предшествующих и сопутствующих его образованию. Использование гидратированного аммония позволяет повысить специфичность приборов в присутствии таких проблемных мешающих примесей, как отработавшие газы двигателей внутреннего сгорания и пары моторных топлив. В настоящей работе обоснован механизм повышения специфичности в присутствии алканов, которые значительно преобладают в указанных мешающих примесях. В отсутствие аммиака, используемого для получения гидратированного аммония, химическая ионизация алканов происходит в результате быстрых экзоэргонических реакций с ионами, предшествующими (O2+•, N2+•, N4+•, H2O+• и H3O+) и сопутствующими (NO+ и NO+(H2O)) образованию гидратированного гидроксония. При добавлении аммиака эти ионы реагируют с ним и практически полностью расходуются в быстрых экзоэргонических реакциях. Тем самым аммиак подавляет химическую ионизацию алканов ионами-предшественниками и сопутствующими ионами. Химическая ионизация алканов непосредственно с помощью гидратированного аммония не протекает вследствие эндоэргоничности реакций и практически полного смещения их равновесия в сторону образования исходных реагентов. В итоге приборы не выдают ложноположительные сигналы при воздействии алканов. Кроме того, приборы не выдают ложноотрицательные сигналы при обнаружении аналитов в смеси с алканами, так как гидратированный аммоний практически не расходуется в реакциях с алканами.
Testing a heterogeneous polarizable continuum model against exact Poisson boundary conditions
Authors: Bowling Paige , Gray Montgomery , Paul Suranjan , Herbert John
Published: December 2024

The polarizable continuum model (PCM) is a computationally efficient way to incorporate dielectric boundary conditions into electronic structure calculations, via a boundary-element reformulation of Poisson's equation. This transformation is only rigorously valid for an isotropic dielectric medium. To simulate anisotropic solvation, as encountered at an interface or when parts of a system are solvent-exposed while other parts are assumed to be in a nonpolar environment, ad hoc modifications to the PCM formalism have been suggested, in which a dielectric constant is assigned separately to each atomic sphere that contributes to the solute cavity. The accuracy of this "heterogeneous" PCM (HetPCM) method is tested here for the first time, by comparison to results from a generalized Poisson equation solver. The latter is a more expensive and cumbersome approach to incorporate arbitrary dielectric boundary conditions, but one that corresponds to a well-defined scalar permittivity function, epsilon(r). We examine simple model systems for which a model function epsilon(r) can be constructed in a manner that maps reasonably well onto a dielectric constant for each atomic sphere, using a solvent-exposed dielectric constant epsilon_solv = 78 and a variety of smaller values to represent a hydrophobic environment. For nonpolar dielectric constants epsilon_nonp <= 2, differences between the HetPCM and Poisson solvation energies are large compared to the effect of anisotropy on the solvation energy. For epsilon_nonp = 4 and epsilon_nonp = 10, however, HetPCM and anisotropic Poisson solvation energies agree to within 2 kcal/mol in most cases. As a realistic use case, we apply the HetPCM method to predict solvation energies and pKa values for a blue copper protein. The HetPCM method affords pKa values that are more in line with experimental results as compared to either gas-phase calculations or homogeneous (isotropic) PCM results.
Tensor Train Optimization for Conformational Sampling of Organic Molecules
Authors: Zurek Christopher , Mallaev Ruslan A. , Paul Alexander , van Staalduinen Nils , Pracht Philipp , Ellerbrock Roman , Bannwarth Christoph
Published: December 2024

Exploring the conformational space of molecules remains a challenge of fundamental importance to quantum chemistry: identification of relevant conformers at ambient conditions enables predictive simulations of almost arbitrary properties. Here, we propose a novel approach to enable conformational sampling of large organic molecules where the combinatorial explosion of possible conformers prevents the use of a brute-force systematic conformer search. We employ tensor trains as a highly efficient dimensionality reduction algorithm, effectively reducing the scaling from exponential to polynomial. In our approach, the conformational search is expressed as global energy minimization task in a high-dimensional grid of dihedral angles. Dimensionality reduction is achieved through a tensor train representation of the high-dimensional torsion space. The performance of the approach is assessed on a variety of drug-like molecules in direct comparison to the state-of-the-art metadynamics based conformer rotamer ensemble sampling tool (CREST). The comparison shows significant acceleration of up to an order of magnitude, while maintaining comparable accuracy. More importantly, the presented approach allows treatment of larger molecules than typically accessible with metadynamics.
A note on Polynomial Centro-Symmetric Hesitant Fuzzy Matrices
Authors: Deva D Sunil  , S Lakshmi Krishna , Remya PB
Published: December 2024

Classical and its development towards fuzzy got a wide acceptance due to its divergent real-life applications. Matrix theory is a special tool that is widely used in solving problems of different mathematical situations. Matrix theory can be used in versatile ways in the new concept. Crisis with fuzzy uncertainties are dealt in a good manner with fuzzy matrices. Hesitant Fuzzy Set in an excellent tool for a decision maker to analyze a situation with various possible values. Apart from usual matrices, there exist several useful matrices. Some of them are very helpful in solving complicated practical problems than the existing typical ones! This paper introduces polynomial centro-symmetric hesitant fuzzy matrix with basic properties.
Super Magic Labelling of Complete Bipartite Graphs
Authors: Geethalakshmi S  , Saraswathy D  , Divya Bharathi S
Published: December 2024

The study of graph labelling has focused on finding classes of graphs which admits a particular type of labelling. A graph is called super magic if it admits a labelling of the edges by pairwise different consecutive positive integers such that the sum of the labels of the edges incident with a vertex is independent of the particular vertex. Some constructions of super magic labelling of regular graphs are described. Super magic regular complete bipartite graphs are characterized.
A Score Function of Hexagonal Neutrosophic Number and its Application in Networking Problem Graphs
Authors: Joshvararathinam J  , Geethalakshmi S  , Britto Antony Xavier G
Published: December 2024

In this paper extended the version of single type neutrosophic neutrosophic number real life problems have different ways the problem is solving the networking problem the concept of Hexagonal neutrosophic number has been focused in a distinct framework here develop of a score function and its estimation have been formulated in perspective,networking problem considered here in Hexagonal neutrosophic number finally computation of total completion time of problem.
Stability Analysis Of System Of Functional Equations From A Hotel Model
Authors: Sathya E  , Arunkumar M  , Namachivayam T
Published: December 2024

In this paper, we explore the Ulam - Hyers stability of system of additive functional equations from a hotel model in Banach Space via classical Hyers Method.
Investigation of 15 knots tailwind triggering go-around maneuver of eight flights at the Soekarno-Hatta International Airport using the WRF-ARW model
Authors: Rais Achmad F. , Ismanto Heri , Widyantoro Eko , Umbaran Bayu , Yunita Rezky
Published: December 2024

A numerical simulation of the 15 knots tailwind triggering the go-around
maneuver of 8 flights at the Soekarno-Hatta International Airport was explored. The
Advancer Weather Research an Forecasting (WRF-ARW) numerical weather prediction
model was used to simulate the events. The results showed that WRF-ARW with temporal
and spatial resolutions of 2 minutes and 1 km could simulate the tailwind events. The
tailwind was triggered by the background wind from the Indian Ocean and by cloud
initiation near the final approach path (FAP), then the tailwind speed was reduced by the
wind gust south of the FAP at 11:00 UTC, on November 3, 2021. These findings cannot be
resolved by analyzing in-situ, weather satellite, and radar data with limited coverage and
sensing the wind out of the cloud. It suggests that high-resolution numerical simulation can
be used in the operation of aviation weather investigation. Assimilating observation data to
the model is essential to be investigated for further study to understand the tailwind
mechanism more accurately.
PSYCHOLOGICAL BASIS OF FORMING A SPORTS COACH'S PROFESSIONAL IMAGE
Authors: Shkarlatiuk Kateryna , Koshyrets Viktor , Hubina Alla
Published: December 2024

Purpose. Grounding psychological conditions and ways of forming a professional image based on the disclosure of the structure and image characteristics of a sports coach.
Methods. The following theoretical and empirical methods were used: analysis, synthesis, generalization; a complex of psychodiagnostic methods which allowed to reveal the content and functional parameters of the professional image. For statistical data processing, the Spearman’s coefficient was calculated.
Results. The professional image of a sports coach as a factor of the effectiveness of professional activity is an image of a personality determined by the requirements of the profession and consisting of a relatively constant core (self-concept, social role, values of professional activity and interaction, professionally significant personal qualities) and an external component (culture of communication, choice of a certain model of behavior).
Conclusions. A positive professional image depends on the inner «Self» of a coach: a system of values, beliefs, interests, desires. Such a person has his own dignity, self-respect, is able to be responsible for himself and his future, high professional self-esteem, flexibility in finding creative alternatives. Individual and psychological characteristics of the coach’s personality, which are determinants of the formation of an effective professional image and their manifestation when working with teams, can be used in the process of forming the professional image of a sports coach. The evaluative and productive aspect of the significance of professional activity is based on the synthesis of ideas about the physical and spiritual state of the professional, the influence of colleagues, appearance, professional competencies necessary in the course of performing production tasks.
Establishment of hospital-based parenting education program in Karachi, Pakistan.
Authors: Bhamani Shelina , Aslam Kiran , Shams Misbah , Sheikh Sara , Farooq Hajra , Shariq Fatima , Sheikh Lumaan
Published: December 2024

The following editorial accentuates the role of responsive caregiving and efficacious parenting strategies, specifically during the first 1000 days of a child's life and early childhood development, especially for children in low- and middle-income countries. Adequate and potent parenting interventions proficiently contribute to the early years of a child's life and lead to overall positive outcomes in the future. This editorial aims to introduce the first-ever Hospital-based Early Childhood Development Parenting Readiness Program (ECD-PREP) initiated by the Department of Obstetrics and Gynaecology, Aga Khan University, and narrates the model in use. The program strongly advocates early childhood development, responsive parenting, and caregiving by integrating nurturing care into care practices and guaranteeing each child's holistic development and future well-being.
Radiological and functional outcome of talus fracture in local population: Our experience in Government tertiary care trauma center.
Authors: Farhan Sozera  , Faheem Ahmed Abbasi  , Syed Akmal Sultan  , Affan Tayyab  , Mehmood Raza
Published: December 2024

Background: Talus fractures pose significant challenges in orthopedic management, particularly in lower socioeconomic populations. Open Reduction and Internal Fixation (ORIF) is a commonly employed surgical approach to restore joint congruity and function. However, outcomes in such populations may be influenced by factors like access to healthcare and postoperative rehabilitation. This retrospective study aimed to evaluate the radiological and functional outcomes of talus fractures treated with ORIF in a lower socioeconomic class population.
Methodology: The study was conducted at a Tertiary Care Trauma Centre and involved 11 patients aged 18-25. Preoperative planning included X-rays and 3-dimensional Computed Tomograms (CT Scans) of the ankle joint. Surgical approaches included the standard medial approach, a dual approach, and an approach with medial malleolus osteotomy. Functional outcomes were assessed using the American Orthopedic Functional Ankle Scoring (AOFAS). Radiological outcomes were evaluated through postoperative X-rays, with reduction considered satisfactory if < 2 mm joint step was achieved. Incidence of avascular necrosis of the Talus (ANT), post-traumatic arthritis (PTA), and other complications were analyzed.
Results: With a mean follow-up of 18 months, concentric reduction was achieved in 85% of cases. Postoperative complications included PTA of the subtalar joint in 45.4% of patients, PTA of the ankle joint in 20%, Avascular Necrosis (AVN) in 18.1%, delayed union in 9%, and surgical site infection (SSI) in 9%.
Conclusion: Despite advancements, talus fractures treated with ORIF remain challenging, especially in lower socioeconomic populations. High complication rates highlight the importance of meticulous surgical planning and postoperative management. Nonetheless, ORIF offers acceptable functional outcomes and facilitates early return to work in these patients.
Assessing the needs of healthcare providers to comply with the Sindh Health Service Providers and Facilities Act (2021) on violence prevention in Karachi, Pakistan.
Authors: Ali Syeda Tabeena , Muffadil Tasneem , Yasir Muhammad , Otho Muhammad Suleman , Siddiqui Muhammad Bilal
Published: December 2024

Background: Workplace violence against healthcare providers is a serious issue in Pakistan. In 2021, the Government of Sindh enacted legislation titled “The Sindh Health Service Providers and Facilities (Prevention of Violence and Damage to Property) Act” to address this problem. This study aimed to assess the needs of healthcare providers in complying with this Act.
Methodology: A cross-sectional quantitative survey was conducted among 384 healthcare providers in emergency departments of selected public and private hospitals in Karachi. Data was collected using a structured questionnaire and analyzed using descriptive and inferential statistics.  
Results: Significant gaps were identified in implementing security measures, incident reporting systems, staff training, and collaboration with law agencies, indicating the need for improvement. Key challenges reported were lack of resources, ethical issues in reporting, and inadequate response by authorities.
Conclusion: Targeted strategies are required to enhance healthcare providers’ capacity in compliance with the Violence Prevention Act. Priorities include policy dissemination, infrastructure upgrades, streamlined reporting and referral pathways, and training healthcare staff on legal rights and response protocols. Effective implementation of the Act can promote healthcare staff safety and delivery of quality care.
Genetic Analysis for Early Diagnosis of Breast Cancer.
Authors: Amna Amin Sethi  , Nisar Ahmed Shar
Published: December 2024

Background: Breast cancer is the most prevalent cancer type among women globally, constituting approximately 25% of all cancer cases. While germline mutations in BRCA1/BRCA2 genes are well-established risk factors for breast cancer, there remains a need to identify additional genes contributing to disease development. Understanding the genetic landscape beyond BRCA1/BRCA2 is crucial for elucidating disease heterogeneity and developing targeted therapies.
Methodology: This study aimed to identify novel genes implicated in breast cancer development by analyzing genomic and clinical data from patients with six different breast cancer types. Utilizing various databases including NCBI, ENSEMBL, Clinical Variance, cBioPortal, COSMIC, DAVID, and OMIM, we conducted a comprehensive genetic analysis. Additionally, a survey was conducted to assess public perception of breast cancer.
Results: Our genetic analysis revealed a significant overlap in genes associated with different breast cancer types, identifying NF1, PIK3CA, and TP53 as common genes across all types. Furthermore, the survey highlighted a lack of awareness regarding breast cancer causes and preventive measures among the general population.
Conclusion: Beyond BRCA1/BRCA2, identifying common genes like NF1, PIK3CA, and TP53 sheds light on potential targets for therapeutic interventions across various breast cancer types. Promoting awareness and education, particularly on self-examination procedures, is imperative to empower individuals in breast cancer prevention and early detection efforts.
Unveiling the risks: Navigating operative and Post-Operative complications in Transurethral Resection of Bladder Tumor.
Authors: Haneef Faisal , Gazder Tanzeel , Yasir Sindhi  , Naz Kanwal , Seetlani Vikram , Kumar Sanjeet , Jameel Harris , Khalique Abdul , Rabiullah Syed , Zulfiqar Mazahir
Published: December 2024

Background: Transurethral Resection of Bladder Tumor (TURBT) is a cornerstone in the management of non-muscle invasive bladder cancer, yet it poses inherent risks such as bleeding, perforation, electrolyte imbalances, and urinary tract infections (UTIs). Effective intraoperative management is crucial to minimize these risks and optimize patient outcomes. This study aimed to elucidate the spectrum of early complications following TURBT.
Methodology: A descriptive study involving 98 patients was conducted using non-probability consecutive sampling at the Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), over a period of 6 months (February 22, 2022 - August 24, 2022). TURBT procedures were performed under general anesthesia, with patients admitted 24 hours preoperatively and discharged within 48 hours. Follow-up evaluations were scheduled at 1 week and 4 weeks post-resection to document complications.
Results: The study included 98 patients undergoing TURBT. Postoperative complications observed at the first week included increased rates of gross hematuria (20 patients), blood transfusions (7 patients), symptomatic urinary tract infections (3 patients), and acute kidney injury (3 patients). By the fourth week, complications had generally decreased, but persistent issues included urinary tract infections (10 patients), fever (10 patients), and acute kidney injury (4 patients). The duration of the procedure and tumor size significantly influenced complication rates, with longer procedures and larger tumors associated with higher incidences of fever, urinary tract infections, and acute kidney injury.
Conclusion: The study highlights that longer TURBT procedures and larger tumor sizes are associated with increased postoperative complications, including fever, urinary tract infections, and acute kidney injury. Effective management strategies and early detection of bladder cancer may help reduce these complications.
Electrolyte imbalance monitoring following Transurethral Resection of the Prostate: A Descriptive Case Series Study
Authors: Hussain Buriro Muslim , Gazder Tanzeel , Muhammed Saad Hafiz , Kumar Sanjeet , Zafar Zuhaib , Khalique Abdul , Ahmed Imtiaz , Bangwar Abdullah , Zulfiqar H. Mazahir , Rabiullah Syed
Published: December 2024

Background: Transurethral resection of the prostate (TURP) is a widely performed procedure for managing urinary obstruction caused by benign prostatic hyperplasia. Despite its efficacy, TURP often results in postoperative electrolyte imbalances, which require careful monitoring and management to avoid complications. This study addresses a critical gap in the literature by examining the prevalence and severity of these imbalances within the local population of Karachi, Pakistan.
Methodology: This descriptive case series study was conducted in the Department of Urology at Sindh Institute of Urology and Transplantation (SIUT) from September 12, 2018, to March 11, 2019. It included 200 patients aged 50 to 70 years undergoing TURP. The procedures were performed under spinal anesthesia with patients in the lithotomy position, the alterations in serum electrolyte levels were observed in each patient. Data were analyzed using SPSS 21.0.
Results: This study included 200 patients aged 50-70 years (mean age: 60.32 years) undergoing TURP at SIUT. The mean BMI was 25.45 kg/m². Preoperative sodium levels averaged 136.52 mEq/L, decreasing to 133.15 mEq/L postoperatively. Preoperative potassium levels averaged 4.46 mEq/L, decreasing to 4.25 mEq/L postoperatively. Electrolyte derangement was observed in 49 patients (24.5%), with a significant mean sodium decrease of -9.75 mEq/L (p<0.01) and potassium decrease of -0.48 mEq/L (p=0.003) in these patients.
Conclusion: Electrolyte imbalances are common following transurethral resection of the prostate and timely, appropriate correction can prevent significant morbidity and mortality.
Assessing the knowledge and practices of anesthesiologists in anesthesia machine maintenance, calibration, and cleaning.
Authors: Ahmed Hasham , Aziz Tarique , Naeem Kashif , Wanwari Mahender , Ur Rehman Adeel , Hasan Muhammad Farhan
Published: December 2024

Background: Anesthesia equipment plays a vital role in ensuring patient safety and effective management during surgeries and other medical procedures. However, the maintenance, calibration, and cleaning of these devices are often overlooked. As anesthesia machines become more complex, incorporating computerized systems and microprocessors, the challenges related to their upkeep have increased. Proper knowledge and training among anesthesiologists are essential to ensure the effective functioning and safety of these devices. This study aimed to assess the knowledge of anesthesiologists working in Karachi’s tertiary care institutions regarding the maintenance, calibration, and cleaning of anesthesia devices
Methodology: This cross-sectional study was conducted in four major tertiary care hospitals in Karachi: The Indus Hospital, Aga Khan University Hospital, Civil Hospital, and Liaquat National Hospital, from July to December 2022. A total of 119 anesthesiologists participated in the survey. A structured questionnaire was used, consisting of 24 questions divided into six sections: demographic information, general knowledge, maintenance, calibration, cleaning, and sterilization of anesthesia equipment, and general opinions on anesthesia equipment maintenance. Data was collected using a self-administered questionnaire designed to evaluate anesthesiologists' understanding of these critical procedures.
Results: The study sample had a mean age of 33.31±5.51 years. A significant portion of participants, specifically 74.8%, 67.2%, and 56.3%, demonstrated inadequate knowledge regarding the maintenance, calibration, and cleaning of anesthesia equipment, respectively. These findings highlight a critical gap in knowledge across all aspects of equipment upkeep. Demographic factors such as age, gender, education level, and work experience did not show any statistically significant correlation with knowledge levels.
Conclusion: The study reveals a concerning lack of knowledge among anesthesiologists in Karachi regarding the essential procedures for the maintenance, calibration, and cleaning of anesthesia devices. This knowledge gap could lead to adverse patient outcomes due to malfunctioning or improperly maintained equipment. These findings underscore the need for targeted educational interventions and training programs to improve anesthesiologists' proficiency in maintaining the safety and functionality of anesthesia equipment.
A comparative study of Silodosin vs. Tamsulosin in the management of Benign Prostatic Hyperplasia: Outcomes in a tertiary care setting in Karachi.
Authors: Seerat Ul Uroos  , Mohsin Anwer  , Sumaiya Noor  , Muhammad Rashid
Published: December 2024

Background: Lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) are prevalent among aging males, with acute urinary retention (AUR) being a common urological emergency. Alpha-blockers, such as tamsulosin and silodosin, are widely used in managing BPH-related LUTS and improving outcomes in Trial Without Catheter (TWOC). However, the comparative efficacy of these two medications remains a topic of clinical interest. This study aims to compare the efficacy of tamsulosin versus silodosin in achieving successful TWOC and improving the International Prostate Symptom Score (IPSS) in patients with BPH at a tertiary care hospital in Karachi.
Methodology: A randomized controlled trial was conducted involving 100 male patients with BPH, aged 45-85 years, who were randomly assigned to two groups: Group A (silodosin, 50 patients) and Group B (tamsulosin, 50 patients). The primary outcomes included successful TWOC (defined as a post-void residual volume of <100 ml) and improvement in IPSS after one month. Statistical analyses were performed using the chi-square and Mann-Whitney U tests, with a significance level set at P ≤ 0.05.
Results: In Group A, 70% of patients achieved a successful TWOC, compared to only 20% in Group B (P = 0.001). The mean IPSS score in Group A was significantly lower than in Group B (P = 0.001), indicating better symptom control with silodosin.
Conclusion: Silodosin demonstrated superior efficacy in facilitating TWOC success and reducing LUTS compared to tamsulosin. These findings suggest that silodosin should be considered the preferred alpha-blocker for managing BPH, especially in patients with AUR, offering improved outcomes for both catheter removal and symptom relief.
Lipid profile alterations in Young Adults using Smokeless Tobacco: A prospective observational study from an urban center in Pakistan.
Authors: Farhan Haleem  , Faisal Tahir  , Syed Ali Jafri  , M. Faizan Adil  , Basit Mahesar  , Sabir Ali  , M. Ali Khan
Published: December 2024

Background: Smokeless tobacco (ST) use is a prevalent health concern in South Asia, with increasing consumption among young adults. While the association between smoking and cardiovascular diseases (CVDs) is well-documented, the impact of ST on lipid profiles and related cardiovascular risks remains underexplored. This study aims to assess the lipid parameters in young adult ST users to evaluate potential dyslipidemia and its implications for cardiovascular health.
Methodology: This prospective observational study was conducted at Sindh Government Hospital Liaquatabad from November 2021 to April 2022. A total of 100 participants aged 18-30 years, who self-reported regular use of ST for at least 12 months and were non-smokers, were included. Lipid profiles, including total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured after an overnight fast. Patients on lipid-altering medications or with significant comorbidities were excluded. Statistical analysis was performed using SPSS version 22.0.
Results: The cohort predominantly consisted of young men (87%), with a mean age of 21.72 ± 3.66 years. Most participants were students (57%) and from low socioeconomic backgrounds (89%). Overall, lipid levels were generally within normal ranges, with the exception of low levels of HDL-C, which were particularly pronounced in women. In detail, the mean HDL-C for men was 41.55 ± 6.94 mg/dL, whereas women exhibited significantly lower HDL-C levels at 30.09 ± 5.94 mg/dL (p < 0.01). Other lipid parameters, including LDL-C, total cholesterol, and triglycerides, did not show significant elevations. Specifically, the mean LDL-C was 147.16 ± 3.60 mg/dL for men and 136.36 ± 9.96 mg/dL for women (p < 0.01), while total cholesterol levels averaged 125.70 ± 23.81 mg/dL for men and 124.55 ± 27.52 mg/dL for women (p = 0.882). Triglycerides were comparable between genders, with men at 131.21 ± 17.14 mg/dL and women at 131.91 ± 20.70 mg/dL (p = 0.902).
Conclusion: This study found that while overall lipid levels were normal, female participants exhibited significantly low levels of HDL-C, indicating potential gender-specific cardiovascular risks.
Targeting Chromosome 21 Gene Over-Expression: A Novel Approach to Prevent Health Complications in Individuals with Down Syndrome.
Authors: Zardari Shehnila , Shar Nisar Ahmed , Chohan Afshan , Majeed Ayesha
Published: December 2024

Background: Down Syndrome (DS), caused by an extra copy of chromosome 21, leads to over-expression of 200–300 genes. This genetic imbalance contributes to various health complications, including an elevated risk of blood cancers. Modulating gene expression is vital to mitigating these risks.
Methodology: This study focused on reducing the over-expression of genes on chromosome 21 by inhibiting the proteins they encode. Potential inhibitors were identified and evaluated using electrostatic interaction scoring and protein docking simulations. The goal was to reduce gene expression by 50%, thereby mitigating the harmful effects of over-expressed proteins.
Results: Analysis confirmed significantly higher expression levels of chromosome 21 genes in DS individuals. Targeting the encoded proteins successfully reduced gene expression by 50%. Protein docking studies identified a promising inhibitor that effectively blocked over-expressed proteins, demonstrating potential to prevent blood cancer by mitigating the effects of the extra genetic material.
Conclusion: This study proposes a novel therapeutic strategy for DS by focusing on inhibiting the over-expressed proteins linked to blood cancer. The identified drug candidates hold promise for improving health outcomes and quality of life in individuals with DS by reducing the risk of blood cancers and other complications.
LANGUAGE AND PLEASURE RESHAPE POWER DYNAMICS IN MARGARET ATWOOD'S THE HANDMAID’S TALE
Authors: Pal Vikash Raj
Published: December 2024

After being published in 1985, Margaret Atwood's well praised work The Handmaid's Tale quickly gained recognition and was included in the canon of literature. Offred, a handmaid in a totalitarian society where people are constantly watched, is the protagonist of this dystopian novel. In this repressive culture, power is heavily exercised in all spheres of life. This essay employs media researcher John Fiske's cultural theories to investigate the workings of power. It explores language's dual uses as a tool of resistance and authority, emphasizing the roles pleasure and discipline play in Gilead's power structure. In The Handmaid's Tale, people continuously rebel whenever they get the chance, even in the face of a totalitarian government. As such, they are neither simple commodities nor passive things. This essay also examines the significant impact that pleasure plays in these people's resistance and captivity. Lastly, it clarifies how people use guerilla warfare to oppose the ruling class.
İncirliova Erbeyli Köyü Sarı Hüseyin Ağa Külliyesi
Authors: Atıcı Alper
Published: December 2024

İncirliova, günümüzdeki idari taksimata göre Aydın’a bağlı bir ilçedir. Doğusunda Aydın, batısında Germencik, kuzeyinde Tire, güneyinde ise Büyük Menderes Nehri ve Koçarlı ilçesi yer almaktadır. Erbeyli köyü, İncirliova’nın güneybatısında, ilçe merkezine yaklaşık 9 km mesafededir. Erbeyli, Osmanlı Dönemi’ndeki idari taksimata göre Aydın Vilayeti’nin Güzelhisar kazasına bağlı mahalleler arasında yer almaktadır. Osmanlı Devleti kaynaklarında Erbeyli adı ilk olarak 1461 tarihindeki defterde geçmektedir. Çalışmaya konu olan külliye Erbeyli köyü içinde düz bir alana konumlandırılmıştır. Cami merkezli külliyenin kuzeydoğusunda medrese, sebil ve batısında hazire bulunmaktadır. İnşa tarihi tam olarak bilinmemekle birlikte caminin kapısının yukarısında Sarı Hüseyin Ağa tarafından 1891 yılında inşa ettirildiği yazılıdır. Cami, plan düzenlemesi bakımından tek kubbeli kübik gövdeli camilere bir örnektir. Yapı, tek kubbeli kübik gövdeli camilerden mihrap yönündeki kubbeli bölümün kuzeyine eklenen üç bölümlü kubbeli mekânla harimin dikdörtgene uzatılmasıyla farklılık göstermektedir. Cami, plan ve mimari özellikleri itibariyle döneminin özelliklerini sergilemesinin yanı sıra Batılı sanat akımlarının da etkisiyle Osmanlı sanatında görülen bezeme programına sahiptir. Bir dönem kulüp binası olarak da kullanılan medrese, külliyenin doğu ve kuzey sınırını belirleyen iki ayrı dikdörtgen kütleli binadan meydana gelmektedir. Medrese, malzeme bakımından cami ile benzer özellikler sergilediğinden cami ile çağdaştır. Sebil, malzeme ve inşa tekniği bakımından değerlendirildiğinde cami ve medreseden farklı zamanda inşa edilmiştir. Caminin batısındaki hazirede yapının banisi ile ailesine mensup kişilerin mezarları bulunmaktadır. Mezar taşlarının bezeme kompozisyonunda akant yaprakları, asma ağacı, servi ağacı ve vazodan çıkan çiçek motifleri görülmektedir. Cami ve mezar taşlarındaki süslemeler üslup bakımından değerlendirildiğinde 18. yüzyılın ikinci yarısından 20. yüzyılın ilk yarısına kadar Batı Anadolu’da görülen motif ve kompozisyonlar oldukları anlaşılmaktadır.
Pelatihan Pembuatan Botol Bambu Laminasi (Laminated Bamboo Bottles) Kelompok Wanita Tani Subur Desa Gondang Kabupaten Lombok Utara
Authors: Febriana Tri Wulandari  , Raehanayati  , Kornelia Webliana  , Diah Permata Sari  , Rima Vera Ningsih
Published: December 2024

Pengabdian terkait bambu diawali dengan melakukan penelitian sifat fisika dan mekanika beberapa jenis bambu pada beberapa Kawasan yaitu HKM Aik bual, KHDTK Senaru dan Sumbawa pada tahun 2019 dan 2020, tahun 2021 melakukan pembuatan bambu menjadi papan laminasi dan tahun 2022 melakukan kegiatan pengabdian papan laminasi bambu menjadi produk cutting board bamboo (talenan bambu). Selain dapat meningkatkan nilai ekonomis bambu juga mendukung pemanfaatan bahan baku yang ramah lingkungan (eco green) dalam rangka mengurangi penggunaan bahan baku plastik.  Pelatihan ini diharapkan mendukung pemanfaatan bahan baku yang ramah lingkungan, menambah lapangan kerja dan meningkatkan ekonomi masyarakat desa. Tujuan penyelenggaraan kegiatan ini yaitu: memberikan modul tahapan pengawetan bahan baku bambu dan pembuatan botol bambu laminasi, menyediakan peralatan pembuatan bahan pengawet untuk bahan baku bambu, menyediakan peralatan pembuatan botol bambu laminasi dan menyediakan peralatan packing botol bambu laminasi. Hasil kegiatan pengabdian menunjukan peserta sangat antusias untuk mengembangkan produk botol bambu karena teknologi yang mudah dan sederhana sehingga peserta mudah memahami dan mengembangkan produk tersebut. Pemberian modul berupa leaflet diharapkan dapat memudahkan peserta kelompok usaha wanita tani subur memahami tahapan dalam pembuatan botol bambu.
Cadernos de Pesquisa, Ensino e Extensão volume 16: Extensão
Authors: Castro Marlon D'Oliveira , Santos Francisco Ewerton Almeida dos
Published: December 2024

o volume 16 dos Cadernos de Ensino, Pesquisa e Extensão, intitulado "Extensão" é fruto do trabalho dedicado de pesquisadores, educadores e estudantes, consolidado a partir dos artigos apresentados no XII Seminário de Institutos, Colégios e Escolas de Aplicação (XII SICEA), realizado na Universidade Federal do Pará (UFPA) em novembro de 2023.
Analisis Kinerja Keuangan Sebelum dan Setelah Penerapan PSAK 22 Pada PT Sejahteraraya Anugrahjaya Tbk
Authors: Salsabila Anindiya
Published: December 2024

Penelitian ini menjelaskan implementasi akuntansi kombinasi bisnis pada PT Sejahteraraya Anugrahjaya Tbk  setelah  penerapan  PSAK  22 di tahun 2018 dan  menggambarkan  dampaknya  terhadap  kinerja  keuangan  perusahaan. Tujuan penelitian ini adalah untuk mengetahui signifikansi perbedaan kinerja keuangan perusahaan sebelum dan sesudah akuisisi pada periode 2013-2022, dengan menganalisis kinerja keuangan lima tahun sebelum dan lima tahun sesudah akuisisi. Sampel dalam penelitian ini menggunakan teknik nonpurposive sampling yaitu sampel jenuh. Dalam penelitian ini diperoleh 10 laporan keuangan yang menjadi sampel penelitian. Metode yang digunakan dalam penelitian ini adalah kuantitatif dengan menggunakan data sekunder dari laporan keuangan PT Sejahteraraya Anugrahjaya Tbk dan jenis penelitiannya berupa komparatif. Teknik pengumpulan menggunakan dokumentasi dan kepustakaan. Melalui analisis NPM, CR, DER, dan TATO hasil menunjukkan fluktuasi kinerja setelah akuisisi PT Bogor Medical Center terhadap PT Sejahteraraya Anugrahjaya Tbk. Teknik analisis yang digunakan adalah uji statistik deskriptif, uji normalitas, dan uji paired sample t-test dengan bantuan aplikasi SPSS 25 for windows.
Skeptisisme Profesional Akuntan Publik : Perspektif Dari Pengalaman Kerja
Authors: Putra Victor Pramudita , Wilasittha Acynthia Ayu
Published: December 2024

Penelitian ini bertujuan untuk mengetahui perspektif pengalaman kerja akuntan publik terhadap skeptisisme. Metode penelitian yang digunakan adalah kualitatif deskriptif. Sumber data adalah data primer berupa hasil wawancara mendalam kepada lima akuntan publik yang bekerja di KAP XYZ. Hasil penelitian menunjukan bahwa pengalaman kerja merupakan faktor yang penting terhadap skeptisisme profesional akuntan publik karena pengalaman kerja yang lama menyebabkan akuntan publik memiliki pola pikir kritis dalam menganalisis bukti pendukung selama proses audit. Skeptisisme profesional merupakan inti dari integritas audit, memastikan bahwa akuntan publik tidak hanya mengumpulkan bukti yang cukup, tetapi juga secara kritis menilai informasi yang mereka peroleh. Dalam praktiknya, pengalaman kerja memainkan peran sentral dalam mengasah dan mengembangkan kemampuan ini. Pengalaman menghadapi berbagai tantangan di lapangan, seperti kompleksitas industri dan dinamika klien, memberikan perspektif yang mendalam kepada akuntan publik tentang bagaimana mereka dapat mempertahankan independensi dan kehati-hatian yang diperlukan dalam proses audit. Hal tersebut dapat membantu akuntan publik dalam mendeteksi salah saji material pada laporan keuangan. Pengalaman kerja ini ditinjau berdasarkan lama bekerja dan riwayat pekerjaan. Melalui pengalaman ini, akuntan mengembangkan pemahaman mendalam tentang kompleksitas industri, tuntutan regulasi, dan dinamika internal klien mereka, yang semuanya memengaruhi kemampuan mereka untuk menjaga independensi dan kehati-hatian yang diperlukan dalam melakukan audit selain itu pengalaman yang banyak membuat akuntan publik akan terbiasa lebih kritis dalam menghadapi situasi tertentu, mereka akan terbiasa dalam bersikap secara skeptis dan tidak mudah mengabaikan suatu kejanggalan dalam pelaporan keuangan.
Pengaruh Promosi, Distribusi, Dan Harga Terhadap Minat Beli Ulang Produk Ready Meal (RTEM) Di Prima Freshmart Serang
Authors: Prihatma Gugup , Decaprio Renaldy
Published: December 2024

Research formulation: Does promotion have a significant effect on Repurchase Interest in Ready Meal (RTEM) products at PFM Serang. Does distribution have a significant effect on Repurchase Interest in Ready Meal (RTEM) products at PFM Serang? Does price have a significant effect on Repurchase Interest in Ready Meal (RTEM) products at PFM Serang? Do promotion, distribution and price have a significant effect on Repurchase Interest in Ready Meal (RTEM) products at PFM Serang. Promotion Research Results (X1) have no significant influence on Repurchase Interest (Y) in Ready Meal Products at PT Prima Freshmart in Serang City. Distribution (X2) has a significant influence on Repurchase Interest (Y) in Ready Meal Products at PT Prima Freshmart in Serang City. Price (X3) has a significant influence on Repurchase Interest (Y) in Ready Meal Products at PT Prima Freshmart in Serang City. There is a significant influence on Promotion (X1) Distribution (X2) and Price (X3) together (simultaneously) on Repurchase Interest (Y) in Ready Meal Products at PT Prima Freshmart in Serang City.
Pengaruh Gaya Kepemimpinan, Lingkungan Kerja, Dan Budaya Organisasi Terhadap Loyalitas Karyawan Pada PT Gemilang Prasada Abadi
Authors: Andi Andi Yusuf , Adiyanto Yoga Adiyanto , Syamsudin Syamsudin , Firdaus Ahmad , Isnaeni Darmawan Dhany
Published: December 2024

This research aims to determine the influence of leadership style, work environment and organizational culture on employee loyalty at PT Gemilang Prasada Abadi. This research is a replication study using a quantitative approach method. The population of this study was 69 people. The sample was taken using a saturated sample of 69 respondents. Data was obtained from the results of distributing questionnaires to respondents. This research analysis uses multiple linear regression analysis with the results of the analysis showing the influence of leadership style, work environment and organizational culture on employee loyalty at PT Gemilang Prasada Abadi which is proven by the t test which shows t-count > t-table. The results of the f test analysis show that the influence of leadership style, work environment and organizational culture at PT Gemilang Prasada Abadi has a simultaneous effect on employee loyalty. This can be proven from the results of the f test by paying attention to the F-count > F-table value. And the significance value is <0.05. The concentration of this research is on employee loyalty which is influenced by leadership style, work environment and organizational culture. Suggestions for further research are expected to be able to retest based on dimensions and indicators other than those examined in this research.
Corporate Financial Risk Trend Prediction Using ARIMA-Based Machine Learning: A Semantic Literature Review
Authors: Sunaryo Deni , Hamdan  , Anggriani Alfina , Winata Cecilia , Alumi Dian Denta
Published: December 2024

This research discusses the role of artificial intelligence (AI) technology in improving company financial risk predictions through the application of the Autoregressive Integrated Moving Average (ARIMA) model supported by machine learning. Using systematic literature analysis, this research explores how ARIMA, with the help of AI, can be applied in financial risk management to identify short-term and long-term trends, detect financial anomalies, and improve the quality of decision making. ARIMA models based on machine learning enable faster and more accurate identification of abnormal financial patterns, which is very important in helping companies respond to risks that have the potential to disrupt financial stability. Key findings show that the combination of ARIMA and AI not only makes it easier to analyze large and complex financial data, but also expands the potential of data-driven financial risk management by providing deeper insights. By integrating machine learning, ARIMA becomes more effective in handling dynamic and fluctuating financial data, so companies can anticipate risks more proactively. This study underscores the enormous potential of AI and ARIMA in helping companies build adaptive, high-precision risk prediction systems, offering new opportunities to strengthen financial resilience in an ever-changing business environment.
PENGARUH KEPEMILIKAN KELEMBAGAAN, UKURAN DEWAN KOMISARIS, UKURAN PERUSAHAAN, DAN UKURAN KOMITE AUDIT TERHADAP PENGUNGKAPAN ISLAMIC SOCIAL REPORTING (ISR)
Authors: Maulita Dian , Dien Sefty Framitha  , Awalia
Published: December 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kepemilikan kelembagaan, ukuran dewan komisaris, ukuran perusahaan, dan ukuran komite audit terhadap pengungkapan islamic social reporting (ISR). Populasi dalam penelitian ini adalah perusahaan yang terdaftar di Jakarta Islamic index periode 2017-2021.  Metode  yang  digunakan  adalah  purposive  sampling sehingga  12 perusahaan  yang  menyajikan  laporan  keuangan  lengkap  sesuai  dengan  variabel  yang  diteliti  dan  di peroleh  sebanyak  60  sampel  perusahaan.  Teknik  analisis  yang  digunakan  adalah  analisis  regresi berganda. Hasil  penelitian  menunjukan  bahwa Kepemilikan Kelembagaan tidak berpengaruh terhadap pengungkapan Islamic Social Reporting (ISR), Ukuran Dewan Komisaris berpengaruh terhadap pengungkapan Islamic Social Reporting (ISR), Ukuran Perusahaan berpengaruh terhadap pengungkapan Islamic Social Reporting (ISR), dan Ukuran Komite Audit tidak berpengaruh terhadap pengungkapan Islamic Social Reporting (ISR).
JOGOS E ARGUMENTAÇÃO NO ENSINO DE QUÍMICA/CIÊNCIAS
Authors: Batista de Morais Marcos , Vieira da Silva Flávia Cristiane
Published: December 2024

Na presente pesquisa, versamos a respeito dos jogos no ensino de química/ciências e suas potencialidades ao serem trabalhados com o auxílio da argumentação. Nos estudos iniciais acerca dos jogos e suas potencialidades, notamos que, apesar de estar numa crescente, as pesquisas envolvendo a temática ainda necessitam de mais estudos que promovam dialogicidade entre si. Com base nisso, nos propomos a realizar uma análise cienciométrica para investigar a produção científica em periódicos com a última classificação da Capes (2017-2020) em Qualis A. Como descritores de pesquisa, buscamos pelo termo jogo/jogos em um recorte temporal que compreende a artigos publicados nos últimos 5 anos (2019-2023). Um total de 183 pesquisas foram encontradas, com as quais houve uma caracterização a respeito do nível de ensino para o qual se destinavam ou o tipo de pesquisa realizado. Desse quantitativo, 84 foram caracterizados como voltados ao Ensino Médio/Técnico/Pré-vestibular, área de interesse para uma série de observações, como as palavras-chave desses trabalhos, os conteúdos curriculares objetivados e, por fim, suas relações com a argumentação. Nesta última etapa, temos como método a Análise Textual Discursiva (ATD), que foi aplicada nos 5 artigos que tinham a argumentação como objetivo explícito com a aplicação dos jogos. Consideramos que a pesquisa contribui para mais dialogicidade nas áreas de jogos e de argumentação no ensino de ciências, mas que as relações entre essas duas temáticas podem, ainda, ser aprofundadas de forma mais abrangente, observando o potencial de desencadear a argumentação até mesmo em jogos que não têm esse intuito previamente definido.