bluuebunny/crossref_metadata_2025 huggingface dataset:
An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases
Authors: Arutyunova Elena , Jiang Zhenze , Yang Jian , Kulepa Ayodeji N. , Young Howard S. , Verhelst Steven , O’Donoghue Anthony J. , Lemieux M. Joanne
Published: July 2018

Rhomboids are ubiquitous intramembrane serine proteases that cleave transmembrane substrates. Their functions include growth factor signaling, mitochondrial homeostasis, and parasite invasion. A recent study revealed that the Escherichia coli rhomboid protease EcGlpG is essential for its extraintestinal pathogenic colonization within the gut. Crystal structures of EcGlpG and the Haemophilus influenzae rhomboid protease HiGlpG have deciphered an active site that is buried within the lipid bilayer but exposed to the aqueous environment via a cavity at the periplasmic face. A lack of physiological transmembrane substrates has hampered progression for understanding their catalytic mechanism and screening inhibitor libraries. To identify a soluble substrate for use in the study of rhomboid proteases, an array of internally quenched peptides were assayed with HiGlpG, EcGlpG and PsAarA from Providencia stuartti. One substrate was identified that was cleaved by all three rhomboid proteases, with HiGlpG having the highest cleavage efficiency. Mass spectrometry analysis determined that all enzymes hydrolyze this substrate between norvaline and tryptophan. Kinetic analysis in both detergent and bicellular systems demonstrated that this substrate can be cleaved in solution and in the lipid environment. The substrate was subsequently used to screen a panel of benzoxazin-4-one inhibitors to validate its use in inhibitor discovery.
El canto como mecanismo de reparación en las comunidades negras, víctimas de la violencia, del Pacífico colombiano: entretejiéndose con el grupo Integración Pacífico
Authors: Rengifo Carpintero John Alexis , Díaz Caicedo Carmen Helena
Published: July 2018

Este artículo es un escrito en el que se reivindica el papel social transformador del canto en las comunidades ancestrales del Pacífico colombiano, como mecanismo de reparación social, de resistencia política y de resiliencia autobiográfica, bajo el espectro de un acervo de saber cultural históricamente presente, pero siempre dinámico, por medio del papel protagónico de las cantaoras, específicamente, del papel de doña Helena Hinestroza. Todas ellas actúan como maestras en la resignificación de su saber cultural, para sacar a los jóvenes de contextos sociales de violencia, exclusión y marginación, bajo el efecto tónico del cantá. En tal esfuerzo, la metodología que sirve de pretexto epistemológico, para lograr adentrarse en el mundo de lo no representativo, es la decolonial. Con ella se logra evidenciar el papel transformador del canto en el ámbito histórico, pero más aún, de la acción social cotidiana.
Perspectiva de los centros de escritura en Colombia
Authors: Calle Álvarez Gerzon Yair
Published: July 2018

En este artículo se describen 19 centros de escritura (CE) de Colombia, a partir de la información que aparece en sus páginas web y de publicaciones que se han generado sobre las experiencias de estos espacios dentro de las instituciones en que se instauran. La metodología utilizada fue la investigación documental. Para comenzar, se presenta una introducción sobre la lectura y escritura en Colombia; luego, el texto se centra en la descripción de los centros de escritura en la educación superior en el contexto de Colombia, sin embargo se aborda un CE dentro de la educación básica y media, que se ha identificado. Al final, se plantea la perspectiva general de los centros de escritura en el contexto colombiano. Como conclusión, se afirma que los centros de escritura en Colombia son una estrategia reciente, que se ha venido pensando con el propósito de fortalecer los procesos de escritura académica en los estudiantes.
El sistema de gestión ambiental bajo NTC-ISO 14001:2015 para una institución de educación superior desde la planificación y control operacional
Authors: Ortiz González Yenith Cristina , Rincón Laverde Julián Efraín , García Santa Jorge Mario , Gallo Montenegro Mariela
Published: July 2018

Este artículo tiene por objetivo identificar los principales cambios de la NTC-ISO 14001:2015 frente a la versión 2004 (la estructura de alto nivel, el concepto de ciclo de vida del producto, la comunicación externa de los impactos ambientales y el control de los cambios planificados del sistema), y proponer las actividades necesarias para dar cumplimiento a los cambios contenidos en el numeral 8.1, “Planificación y control operacional”, a través de un plan de acción diseñado específicamente para el caso de una institución de educación superior. Para ello, se realizó un análisis comparativo entre las versiones 2015 y 2004 de la NTC-ISO 14001, el cual dio como resultado la identificación de los nuevos requisitos que deben cumplir las organizaciones que deseen mantener la certificación de su sistema de gestión ambiental. La segunda etapa consistió en definir a manera de alternativas las acciones que deben incluir en el plan de acción las organizaciones que deseen llevar a cabo la transición a la versión 2015 de la norma, con el fin de dar cumplimiento a los requisitos identificados en la etapa uno. Después de la revisión, se puede argumentar que sí existen cambios en los requisitos para la transición frente al numeral 4.4.6, “Control operacional”, de la versión 2004, en aspectos como: el enfoque de ciclo de vida de productos y servicios; el control del proceso de diseño y desarrollo; la comunicación externa de posibles impactos significativos asociados a las actividades de transporte, entrega, uso y disposición final de productos y servicios; y el control de la planificación de los cambios que las organizaciones deben cumplir a través de un plan de transición con las actividades señaladas en este documento.
Análisis de percepción de la integración de sistemas de gestión
Authors: León Velásquez Gloria del Pilar
Published: July 2018

Este artículo pretende dar a conocer la percepción de la integración de sistemas de gestión de diferentes tipos de actores que han participado o tienen formación en la integración, específicamente el alcance se desarrolla sobre las siguientes normas: NTC-ISO 9001, OHSAS 18001 y NTC-ISO 14001. Estas pueden ser implementadas de manera individual o integrada al interior de una organización, lo cual incide en obtener o no los diferentes tipos de beneficios, oportunidades y esfuerzos por parte de una entidad. Para ello, se identificaron los componentes principales de un Sistema Integrado de Gestión - SIG, basados en el desarrollo de un marco teórico de autores representativos en el tema, con el que se construyó un instrumento válido que permite a través de su diligenciamiento, rescatar la valoración y apreciación positiva o negativa respecto a los diferentes elementos que se asocian a la implementación de un SIG. Los resultados han sido beneficiosos para entender cómo se estima la aplicación de cada elemento y su tendencia en la opinión de los diferentes participantes, en un espacio y tiempo establecido de transición de las normas ISO. El instrumento diseñado da la oportunidad y posibilidad de ser utilizado para verificar cómo evoluciona la aceptación de conceptos, metodologías, secuencia de integración, componentes y determinar aspectos estratégicos, beneficios, dificultades y posibles desventajas que se puedan ocasionar al implantar un SIG en una organización. La importancia de este trabajo es dar un primer paso para identificar la percepción de la integración de sistemas de gestión, en una etapa de transición de la norma NTC-ISO 9001 para poder valorar hasta qué punto hay homogeneidad o heterogeneidad en la apreciación de los elementos que la componen.
Revisión sistemática de teorías de integración de sistemas de gestión normalizados
Authors: Malagón Medina Angélica
Published: July 2018

Este artículo presenta los resultados de una revisión sistemática efectuada en Scopus, EBSCOhost y Unbis Thesaurus (United Nations Bibliographical Information System) y e-libro. La búsqueda consideró textos publicados entre el 2000 y el 2016. La recuperación de estos documentos se efectuó a través de palabras clave en inglés y español: integration of management systems, integration of management systems and systematic review, standards, industrial management. Se identificaron 998 documentos y se identificó que el 2014 es el año con mayor producción relacionada. Dentro de la literatura científica, se pudo identificar que algunas revisiones sistemáticas de teorías de integración de sistemas de gestión son aplicadas a diferentes sectores económicos a nivel mundial, sin embargo, se tiene poca información del tema de investigación, los aportes son escasos; generando vacíos y dificultades para el análisis e interpretación de los elementos comunes de los aportes de teorías de integración de sistemas de gestión normalizados como ISO 9001, ISO 14001, OHSAS 18001.
Exploring Inductive Grammar Teaching: English Teacher Perspectives
Authors: Hidayat Didin Nuruddin
Published: July 2018

ABSTRACT In the past few decades, the discussion of what grammatical structures to teach, and how to teach them remains controversial (Ellis, 2006). This research study aimed to explore the role of inductive grammar teaching toward specific grammatical structure, i.e. the second conditional or the unreal/hypothetical conditional. In light of this, ten English teachers were involved in this study, providing beneficial feedback through their experience in English language teaching. They were given two sessions of inductive grammar teaching, and were asked to provide feedback. The results showed that inductive grammmar teaching possessed its strengths and weaknesses. One strength would be from its ability in engaging more active participation from the students. However, a notable weaknessess was in terms of its lack of opportunities in explicit grammatical explanation. ABSTRAK Dalam beberapa dekade terakhir, diskusi tentang struktur tata bahasa apa yang perlu diajarkan, dan bagaimana mengajarkan struktur tata bahasa tersebut tetap menjadi isu yang kontroversial (Ellis, 2006). Penelitian ini bertujuan untuk mengeksplorasi peran pengajaran tata bahasa induktif terhadap struktur tata bahasa tertentu, yaitu the second conditional atau the unreal/hypothetical conditional. Untuk itu, sepuluh guru bahasa Inggris dilibatkan dalam penelitian ini, memberikan umpan balik yang bermanfaat melalui pengalaman mereka dalam bidang pengajaran bahasa Inggris. Mereka diberi dua sesi pengajaran tata bahasa induktif, dan diminta untuk memberikan umpan balik. Hasilnya menunjukkan bahwa pengajaran grammmar induktif memiliki kekuatan dan kelemahannya. Salah satu kekuatan berasal dari kemampuannya dalam melibatkan partisipasi yang lebih aktif dari para siswa. Namun, salah satu kelemahan yang menonjol adalah dalam hal kurangnya peluang dalam menjelaskan tata bahasa secara eksplisit.   How to Cite: Hidayat, D.N. (2017). Exploring Inductive Grammar Teaching: English Teacher Perspectives. IJEE (Indonesian Journal of English Education), 4(2), 111-119. doi:10.15408/ijee.v4i2.8538.
The Effect Of Moral Integrity, Lifestyle And Organizational Culture On Anti-Corruption Intention
Authors: Putri Dhiny Aditama , Nihayah Zahrotun
Published: July 2018

This study aims to examine the effect of moral integrity, lifestyle and organizational culture on anti-corruption intention involving 54 police officers and 97 civil servants of police in police institution X. Sampling technique in this study using non-probability sampling. The measuring tool used in this study consists of the Anti Corruption Intelligence Scale which the authors develop themselves to measure the anti-corruption intention, Moral Integrity Scale to measure moral integrity, AIO Psychographic to measure lifestyles, and the Denison Organizational Culture Survey to measure organizational culture. Confirmatory Factor Analysis (CFA) was used to test the validity of measuring instrument and Multiple Regression Analysis is used to test the research hypothesis. The results revealed that there was a significant of moral integrity, lifestyle and organizational culture against anti corruption intention at 56.3%. It means that the proportion of varians of anti-corruption intention in can be explained by moral integrity, lifestyle, and organizational culture at 56.3% and 43.7% explored by other factors.  DOI:10.15408/tazkiya.v22i2.8413
Knowledge and attitudes of Brazilian dentists regarding dental treatment of children
Authors: Goettems Marília Leão , Azevedo Marina Sousa , Rubin Dayane , Prietto Núbia Rubin , Pauli Laís Anschau , Demarco Flávio Fernando
Published: July 2018

OBJECTIVE: This survey assessed the attitudes of dentists regarding dental treatment of children, the barriers reported, and knowledge about the recommended age for a child’s first dental visit.METHODS: A self-applied questionnaire was sent to all dentists in Pelotas/Brazil and 187 (67.8%) were returned. The chi-square test was used to analyze categorical or nominal variables; the chisquare test for linear trend was used for the ordinal variables and Fisher’s exact test was used when the cell frequencies were small. The level of significance was set at α=0.05.RESULTS: The majority of the dentists provide dental treatment for children (123; 71.9%). Regarding the barriers to treatment of children, behavior (55.9%) and interest of parents (48.2%) were the most cited. Only 65.9% reported that children should see a dentist no later than 12 months of age. Knowledge about the recommended age was higher among pediatric dentists (p=0.03) and lower among dentists in private practice (p=0.002) and with more years of practice (p=0.02).CONCLUSIONS: Although most of the dentists treat children, barriers have been pointed out. Many of the dentists are not aware of the recommended age for the first dental visit. Given the benefits of early treatment, this attitude should be stimulated among dental professionals.
Three-dimensional finite element analysis of mandibular overdentures with different implant positions and attachment types
Authors: Broilo Josué Ricardo , Sartori Evandro Afonso , Mariano Luiz Oscar Honorato , Corso Leandro , Shinkai Rosemary Sadami Arai
Published: July 2018

OBJECTIVE: This 3-D FEA study compared the stress distribution in two-implant mandibular overdentures as a function of implant position and attachment system (LA: locator attachment vs. BA: ball attachment).METHODS: Four models of mandibular overdentures were tested: M1-LA – with implants at the canine regions (standard implant position) and LA; M2-LA – with implants placed at the first premolar regions (distalized implant position) and LA; M1-BA – with standard implant position and BA; and M2-BA – with distalized implant position and BA. The geometric models were converted into finite element models. A 100 N axial load was applied at the first molar region. The von-Mises stress distribution was compared in selected points.RESULTS: The models with BA had pattern of stress distribution was more uniform along the implant axis than the ones with LA, although the stress magnitude was larger. The largest area of von Mises stresses on the alveolar ridge was in the models with standard implant distribution.CONCLUSION: The findings showed that the models with BA had better biomechanical behavior than the ones with LA. For both types of attachment, the models with increased inter-implant distance presented a smaller area of stress distribution in the perimplant cortical bone tissue than the standard implant position.
Tinea Corporis Caused by Microsporum Canis in HIV Patient Treated For Neuromeningeal Cryptococcis: Report of A Nosocomial Outbreak
Authors: Yassine Merad , Haiet Adjmi-Hamoudi , Narjess Tabet-Derraz , Zohra Samia Merad Fatima
Published: July 2018

We report a nosocomial outbreak of Microsporum canis during inpatient treatment for HIV newly diagnosed with cryptococcal meningitis. The clinical presentation, though very typical of ringworm infection, samples were collected and examined by direct microscopy and culture on Sabouraud’s dextrose agar, revealing Microsporum canis. It is strongly believed that outdoor cats living in the hospital spaces are the main cause of disease transmission. Measures to limit zoophilic pathogens are necessary in immunosuppressed inpatient care unit
Enhanced Interconnection Model in Geographically Interdependent Networks
Authors: Rueda Diego F. , Calle Eusebi , Wang Xiangrong , Kooij Robert E.
Published: July 2018

Interconnection between telecommunication networks and other critical infrastructures is usually established through nodes that are spatially close, generating a geographical interdependency. Previous work has shown that in general, geographically interdependent networks are more robust with respect to cascading failures when the interconnection radius (r) is large. However, to obtain a more realistic model, the allocation of interlinks in geographically interdependent networks should consider other factors. In this paper, an enhanced interconnection model for geographically interdependent networks is presented. The model proposed introduces a new strategy for interconnecting nodes between two geographical networks by limiting the number of interlinks. Results have shown that the model yields promising results to maintain an acceptable level in network robustness under cascading failures with a decrease in the number of interlinks.
Arithmetic Operations with Spiking Neural P Systems with Rules and Weights on Synapses
Authors: Wang Huifang , Zhou Kang , Zhang Gexiang
Published: July 2018

The application of spiking neural P systems with rules and weights on synapses to arithmetic operations is discussed in this paper. We design specific spiking neural P systems with rules and weights on synapses for successfully performing addition, multiplication and the greatest common divisor. This is the first attempt to discuss the application of the new variant of spiking neural P systems, spiking neural P systems with rules and weights on synapses, and especially the use of spiking neural P systems to perform the greatest common divisor. Comparing with the results reported in the literature, smaller number of neurons are required to fulfill the arithmetic operations.
Planejamento e Avaliação em Saúde: entre antagonismo e colaboração
Authors: Furtado Juarez Pereira , Campos Gastão Wagner de Sousa , Oda Wagner Yoshizaki , Onocko-Campos Rosana
Published: July 2018

Resumo: Analisamos as relações entre duas subáreas da Saúde Coletiva - Planejamento e Avaliação - por meio de estudo bibliométrico de artigos, teses e dissertações, no período entre 1980 e 2016. A produção global relativa à Avaliação supera aquela do Planejamento, com predomínio acentuado a partir de meados da década de 2000. A capacidade de influenciar a gestão do setor Saúde parece impelir a disputa entre as duas subáreas. Considera-se que ambas têm recursos teóricos e metodológicos para superar suas reduções pela lógica instrumental do chamado gerencialismo, e se firmarem como dispositivos de reflexão e mudança.
Analysis of the preparation and administration of medications in the hospital context based on Lean thinking
Authors: Costa Diovane Ghignatti da , Pasin Simone Silveira , Magalhães Ana Maria Müller de , Moura Gisela Maria Schebella Souto de , Rosso Caroline Brum , Saurin Tarcisio Abreu
Published: July 2018

Abstract Objectives: To analyze the current way medications are prepared and administered in the hospital setting and to apply a method to establish priorities for problems detected. Method: This is an exploratory-descriptive case study. The data were collected through observation and focus groups with 13 participants who were part of a health team in a surgical inpatient unit of a public university hospital. The analysis was based on a lean production framework. Results: A value stream map was constructed of the current way drugs are prepared and administered, identifying the clients in the process and their requirements. Forty-five current problems were identified, based on requirements that were not met with eight being prioritized to improve planning. Conclusion: Having prioritized the problems, the planning and implementation of continuous improvements in the medication process were started in order to reduce errors and improve the quality of services.
MethylC-seq using EZ DNA Methylation-Gold Bisulfite and Accel-NGS DNA Library Kits v1
Authors: R Ganguly Diep , Eichten Steven
Published: July 2018

Protocol to useACCEL-NGS® METHYL-SEQ DNA LIBRARY KIT (NGS Prep with Bisulfite-Converted DNA Capability; Cat. No. DL-ILMMS-12/48) to perform MethylC-sequencing in Arabidopsis. Code used to analyse raw sequencing data can be found: Please seehttps://github.com/dtrain16/NGS-scripts/tree/master/MethylC.
Philosophical and anthropological aspect of A.A. Ukhtomsky's teaching about the dominant
Authors: Tkachenko Anastasia S. , Ivanov Dmitry O. , Berezkina Elena N.
Published: July 2018

Development context of scientific thought in the early 20 century let us see the origins of many ideas, that became fundamental in Russian philosophical anthropology. Ukhtomsky’s theory about dominant – the one of the most important in the psycho-physiological development of the 20th century. His ideas useful not only for theoretical physiology, anthropology, psychology, but also in practice, for labor, science and creative activity optimization. Dominant principle – is not only the main way of brain centers cooperation, but also all nervous system and body as a whole. It gives an opportunity to learn the contradictory and hard structure of human behavior, of a moral and creative person components, describes way of human attitude to the external environment as an active, not passive observer. Dominant connects rather elements in a single unit, moving in one direction, and present not only in physiology, but also in psychic experience, literature and art. In the philosophical-ethical attitude A.A. Ukhtomsky was developing the conception of “dominant on the other face”. It addresses on original person, see Interlocutor in his identity and uniqueness. The concept of morality of A.A. Ukhtomsky is based on the definitions of “honored interlocutor” and “double”. Deserve the Interlocutor – means to see in him something bigger, than own reflection. In the science work of A.A. Ukhtomsky we see systematic approach to the study of physiological discoveries and solving real-life problems. In an effort to understand, what a person is, how his mental development takes place, he doesn’t only makes actual discoveries, but also try to give them general scientific significance, to enter them into the general scientific system of knowledge. The systematic scientific approach is particularly relevant at the present time, when the amount of various information is growing exponentially, and the general concept of scientific knowledge, which allows to combine work in various fields of science, doesn’t exist. In our opinion, its base can give us the A.A. Ukhtomsky’s dominant principle.
Maternal obesity and child health at different ages
Authors: Petrenko Yuri V. , Novikova Valeriya P. , Polunina Anna V.
Published: July 2018

In recent years, the number of obese women of childbearing age has increased significantly. The aim of this study was to reveal the influence of maternal obesity during pregnancy on the longterm health of the offspring.

This study was performed in the outpatient clinic in St. Petersburg with 76 adolescents with chronic diseases aged from 6 to 17 years. The mean age of the examined was 12.67 ± 3.19 years; the ratio of girls to boys was 6 : 7. Children were divided into 2 groups: the main group included 26 adolescents whose mothers were obese before and during pregnancy. 50 teen agers from mothers with normal BMI during pregnancy presented comparison group. The main group and the comparison group did not differ in age and sex. The children were examined by a pediatrician. Data on the transferred diseases are obtained from an outpatient card. It has been established that maternal obesity may be considered a risk factor for miscarriage, having low birth weight babies or babies weighing more than 4 kg, as well as a risk factor for rickets, parathrophies and functional constipation in the first year of life. In adolescentes, obesity, euthyroid goiter, hypothalamic syndrome and other endocrinopathies are typical for children born from obese mothers. Several medical conditions related to obesity such as chronic pancreatitis, hiatal hernia, iron deficiency anemia and orthopaedic foot and ankle pathology are commonly seen in children of obese mothers. Maternal obesity is associated with diseases of children not only in the period of newborn, but also in adolescence.
The model of medical and biological support center for sports-gifted children and adolescents
Authors: Kalinin Andrey V. , Butko Dmitry Yu. , Danilenko Larisa A. , Artamonova Marina V. , Teryokhin Vladimir S.
Published: July 2018

One of the main problems of modern sport is propensity for various kinds of sport activity and individualization of the training process. To solve this problem effectively, the Center of testing, selection and support for sports-gifted children and adolescents has been created on the basis of Lesgaft National State University of Physical Education, Sport and Health. The structure of the Center includes the medical and biological department, the genetic department, the department of psychological evaluation and support, the sports and pedagogical department. In each department the individual quotients, based on the collected and analyzed information about the individual's makings and abilities, are compared with the standard requirements in a particular kind of sport. After that the opinion about the general and special sports talent of person is made. Coordination interaction between departments is provided by the Information and Organizational Department of the Center, which conducts final sports consultancy and support on the basis of the complex opinion of the individual profile of the child's sports talent. Individual profile of sports talent allows to determine the degree of development and retardation of main physical qualities and abilities, to define the directions of sport specialization, to develop a training program, to make amendments. Innovative programs of individualizing training process, which are provided in this center, are based on long-term practical experience in sports pedagogic, sports genetics, sports psychology and sports medicine. The center of testing, selection and support to sports-gifted children and adolescents is an innovative institution that has no analogues.
The Effect of Strategic Orientation on Green Supply Chain Practices and Performance: A Case of Manufacturing Companies in Pakistan
Authors: Nadeem Kawish , Siddiqui Danish Ahmed
Published: July 2018

The aim of this study is to find out the direct impact of competence of strategic supply chain orientation, strategic environmental orientation and institutional pressure on Green Supply Chain Management (GSCM) and to overall performance. The data gathered from executives of 66 manufacturing firms of Pakistan. On the one hand, the relationship between strategic orientations of the environment, supply chain, institutional pressure, and adoption of GSCM practices is examined on the other hand GSCM practices, and its relationship with performance measures including Customer Effectiveness, Environmental Differentiation, Economic Performance, Operational Efficiency and Social Performance is examined. The Smart PLS software is used to compute content validity, convergent validity, discriminant validity, and predictive relevance model. The companies in Pakistan are less oriented towards environment and supply chain. However, due to the pressure from institutes, they are persuaded to adopt GSCM practices in their operations, which eventually boost their performance. The outcome of GSCM practices results in saving the environment, creating a better social image, cost reduction and profitability which would enable managers to be able to know strategic orientations (both environmental and SCM) rather than depending on the issues of institutional pressures and monitoring directions of strategies for Green SCM.
Nanobyte
Authors: Vaishnav Radhika A.
Published: July 2018

An unintended effect of CRISPR-Cas-9 gene therapy may be the natural selection of p53-deficient cells. While this was unexpected, it highlights the need for continued basic research and carefully designed clinical trials to evaluate the mechanism and safety of this outcome.
Cancer immunotherapy
Authors: Jain Akhil , Rajpurohit Sajjan
Published: July 2018

The era has begun where oncology meets immunology. The recent advancement in the field of molecular biology has led to the discovery of various pathways through which cancer establishes, proliferates, grows, and disseminates. These pathways provided major insight for targeting specific molecules with the targeted therapies that show predicted responses. This targeted therapy is usually referred to as immunotherapy. These immunotherapies possess and display a unique set of toxicities mainly immunologic in nature and different from chemotherapies. This article focuses on mechanisms of immune activity of the body and various therapies available to boost these mechanisms.
Polybromo-1 loss in cholangiocarcinoma development: Expressional analysis
Authors: Yasri Sora , Wiwanitkit Viroj
Published: July 2018

Dear editor, the cholangiocarcinoma is a deadly hepatobiliary cancer. It results in high fatality in affected persons in endemic Southeast Asia. The patient usually manifests at large stage of cancer and has severe obstructive jaundice. The underlying genetic pathophysiology of cholangiocarcinoma is very interesting. As a cancer, the mutation can be expected (such as KRAS mutation). In a recent publication by Luchini et al., the loss of Polybromo-1 (PBRM1) was observed during the development of cholangiocarcinoma. The similar finding was also reported by another Japanese scientist group. Here, the authors use the standard gene ontology technique to assess the effect of PBRM1 loss comparing to the naïve case. The protocol for gene ontology analysis is the same as previously gene ontology analysis studied. According to analysis, the identified main affected function due to PBRM1 loss is “regulation of chromatin association.” This implies that loss of PMB1 during cholangiocarcinoma development is the important pathobiological process that promotes the abnormal cell division and might stimulate the cancer development. In fact, the loss of PBRM1 is proposed as an important predictor for poor outcome in several cancers such as renal cancer.
Complex three-way Philadelphia translocation t(6;9;22) (p23;q34;q11.2) along with unusual t(1;4): A chronic myeloid leukemia case report
Authors: Kumar M. , Salona Bekleshwar , Kumar Shiv Murti , Gore Akshay , Sharma Shivani
Published: July 2018

Chronic myeloid leukemia (CML) is a myeloproliferative disorder and genetically characterized by the presence of the Philadelphia (Ph) chromosome, resulting from a balanced reciprocal translocation between chromosome 9 and 22 at bands 9q34 and 22q11.2 [t(9;22)(q34;q11.2)]. In the formation of the Ph chromosome, the specific region of the ABL oncogene is transposed from 9q34 to the specific region of the BCR gene on chromosome 22 to form a fusion gene BCR‑ABL, which encodes a constitutively active protein, with tyrosine kinase activity. Vast majority of CML patients show classical Ph translocation, t(9;22) and 5–10% of cases are observed with variant Ph translocation. In variant Ph translocation, generally, the third chromosome involved with chromosome 9 and 22. The segment of the third chromosome usually translocates to the chromosome 9 at band 9q34. The formation of variant or complex Ph translocation is controversial topic. A wide array of additional chromosome involved in translocation with the t(9;22) has been described previously in CML patients. In this report, we present a unique and complex Ph translocation involving three chromosomes (6;9;22) in a 25-year-old female 66who was clinically diagnosed as CML. Chromosome analysis using 24 h and 48 h unstimulated culture with GTG-banding was performed according to standard protocol. A total of 20 metaphases analyzed from the bone marrow culture of the patient and karyotyping was performed on the basis of International System for Human Cytogenetic Nomenclature (2016). The FISH analysis was performed according to the standard protocol from sample for confirmation of BCR/ABL gene using dual color fusion FISH probe (Zytovision Probe). All cell’s images were captured using Olympus fluorescent microscope BX-61 equipped with a CCD camera and analyzed using Bioview FISH software.
Aplicabilidade do GEMS na análise de erros em uma farmácia
Authors: Soares Eva Bessa
Published: July 2018

As formas de ocorrência do erro humano na produção de serviços de uma farmácia são o foco investigativo deste artigo. Utilizou-se a metodologia de Análise ergonômica do Trabalho(AET), que permitiu evidenciar mecanismos causadores dos erros. A análise, a partir do GEMS, dos erros encontrados permitiu elaborar recomendações para reduzir devoluções de produtos farmacêuticos pelos clientes devido a erros (diferenças entre os produtos pedidos e aqueles que chegam a seus endereços).
Gráficos de Controle com uma Abordagem de Séries temporais.
Authors: Ide Mayara Sayuri , Junior José Ivo Ribeiro , Souza Livia Mara
Published: July 2018

Os gráficos de controle X,CUSUM e EWAdA destacam-se como algumas das principais ferramentas do CEP A confiabilidade de sua utilização está ligada ao atendimento das pressuposições de independência e normalidade dos dados. Se a primeira for violada, esses gráficos de controle podem gerar muitos alarmes falsos. Como  os processos se tornam cada vez mais contínuos e com alto grau de automação, o estudo sobre métodos para o seu monitoramento torna-se essencial. O objetivo deste estudo foi avaliar o efeito da autocorrelação sobre a eficiência dos gráficos, bem como encontrar maneiras de minimizar ou eliminar tais efeitos. Os resultados indicaram que, quanto maior a autocorrelação presente nos dados, maior a quantidade de alarmes falsos, independentemente do comprimento da amplitude móvel utilizada para a estimativa do desvio-padrão. Outro prejuízo da aplicação dos gráficos de controle e EWAdA sem nenhum tratamento para autocorrelação dos dados foi a diminuição do poder para os deltas iguais a 2 e 3. A utilização de modelos de série temporais em processos autocorrelacionados mostrou-se capaz de proporcionar alarmes falsos e verdadeiros dos gráficos de controle, CUSUM e EWMA, similares àqueles quando a pressuposição de independência dos dados é satisfeita.
CSVP 2018 Abstracts
Authors: Murray Alison M , Holmes Robert B.
Published: July 2018

CSVP 2018 Abstracts
Evaluation of the preoperative preparation effectiveness with the ozone therapy and NPWT usage in patients with pressure sores after spinal cord injuries.
Authors: Plis Igor , Zarutskii Yaroslav
Published: July 2018

Surgical treatment of 178 patients with pressure sores in the rehabilitation period of traumatic illness was analyzed. A surgical approach of treatment with the use of the NPWT technique in the preoperative period was suggested. A positive effect of NPWT on local microcirculation, neoangiogenesis, bacterial decontamination and tissue repair was found. The indices of immunohistochemical markers CD34, CD68, which reflect the degree of reparative processes in the wound, were determined. The increase in the density of the CD34-expressed vessels and the quantitative index of macrophages CD68+ - 40.8 ± 1.7, with the minimal advantage of the functionally active macrophages are the objective criteria of tissue readiness for plastic closure. The use of (local) musculocutaneous flaps with axial blood supply in combination with anatomical and functional resection of the underlying bones was suggested as a method of plastic surgery of pressure-trophic ulcers, which reduced the number of early postoperative complications. Good and satisfactory results were achieved in 109 (90.8%) patients.
Reflexiones sobre la implementación jurídica del principio de «participación económica de los asociados» en las cooperativas cubanas
Authors: Rodríguez Musa Orestes , Hernández Aguilar Orisel
Published: July 2018

Creciente resulta el debate sobre el cooperativismo en Cuba, en tanto la actualización del modelo socioeconómico nacional renueva el interés por estas peculiares formas de empresa. Como parte de este proceso, la optimización de la regulación y aplicación del principio de «participación económica de los asociados» en las Cooperativas No Agropecuarias ha ganado especial importancia, pues su materialización se ha visto afectada por distintos factores —objetivos y subjetivos— que han dado lugar a conductas desviadas de la identidad cooperativa. Por tal motivo, este trabajo se propone aportar algunas valoraciones teórico/prácticas que contribuyan a revertir esta situación.Recibido: 5 marzo 2018Aceptado: 24 abril 2018Publicación en línea: 24 julio 2018
Paternidade na gestação e parturição: uma revisão integrativa
Authors: Martins Aline De Carvalho , Barros Geiza Martins , Mororó Géssica Martins
Published: July 2018

O objetivo deste estudo foi identificar, através dos últimos 10 anos da produção científica brasileira, as vivências experimentadas pelos homens durante o período gestacional e perinatal. Trata-se de uma revisão integrativa feita com 152 estudos. Os resultados apontam que os homens nem sempre são estimulados a participar do pré-natal e que desejam participar do parto como modo de reforçar o vínculo do casal. Ao participar do parto vivenciam dores e emoções próprias e passam a reconhecer suas mulheres como fortes e corajosas e se auto avaliam positivamente, considerando-se como homens de confiança. As vivências do homem durante o período gestacional apontam para medos, redefinição de seu papel social e para o alijamento de sua participação nos serviços de saúde. A parturição associa-se a um processo transformador das vivências interiores do próprio homem, do estreitamento dos vínculos com a mãe de seu filho e do fortalecimento dos laços com o bebê.
Exame clínico e suas implicações para a efetividade do processo de enfermagem
Authors: Souza Patrícia Cristine Barbosa de , Cordeiro Aldenora Laisa Paiva de Carvalho , Cardoso Michelle Morais , Costa Daniela Galdino , De Oliveira Fabíola Cardoso , Stacciarini Thaís Santos Guerra
Published: July 2018

Este trabalho teve por objetivo analisar o registro do exame clínico realizado pelo enfermeiro, e descrever suas implicações para a efetividade do PE em um hospital de ensino. Trata-se de um estudo descritivo, transversal e documental. Verificou-se no formulário os itens para registro do exame clínico: identificação do paciente, necessidades humanas básicas, escalas e identificação profissional. Analisou-se que dos 371 prontuários, três (0,8%) não constava informações quanto a identificação do paciente. A regulação neurológica apresentou maior percentual de informações completas, com 63,3% prontuários preenchidos adequadamente. Mobilidade, cuidado corporal e sono e repouso apresentaram o maior número de ausência de informações com 20,8% formulários em branco. Em 25,3% prontuários não constaram identificação profissional. Conclui-se que o registro do exame clínico realizado por enfermeiros ainda é falho, apresentando grande número de informações incompletas comprometendo a efetividade do Processo de Enfermagem.
Miedo al Delito, Victimización y Satisfacción con la Vida en México
Authors: Martinez-Ferrer Belen
Published: July 2018

El objetivo del presente estudio es examinar las relaciones existentes entre miedo al delito, victimización y satisfacción con la vida, en función del género. La muestra estuvo conformada por 7535 sujetos de ambos sexos (49.8 % mujeres y 50.2 % hombres) de entre 12 y 70 años, seleccionados a partir de un muestro estratificado proporcional. El instrumento de medida fue una adaptación de la Encuesta Nacional de Victimización y Seguridad Pública de México. A partir de un MANOVA factorial multivariante se observó que el miedo al delito, la victimización y las medidas de protección frente a la delincuencia se relacionaban con una pobre satisfacción con la vida. También se observó, respecto del sexo, que los hombres tenían mayor miedo al delito y realizaban más restricciones en su vida cotidiana. Finalmente, se discuten los resultados y sus implicaciones prácticas.
Flexibilidad psicológica y atención plena: analizando su valor añadido sobre los niveles de energía y motivación entre enfermeras procedentes de España y Cuba.
Authors: Blanco Donoso Luis Manuel , Moreno Jiménez Bernardo , Llanta Abreu María del Carmen , Martínez Ochoa Yanelys , Garrosa Eva
Published: July 2018

La energía y motivación de los profesionales de enfermería son fundamentales para su bienestar, para garantizar la calidad asistencial, así como la permanencia de los trabajadores dentro de las organizaciones con altos niveles de compromiso. El objetivo de este trabajo fue explorar el valor añadido que tenían dos recursos personales del propio trabajador: su flexibilidad psicológica y atención plena, sobre sus niveles de vigor y agotamiento emocional relacionados con el trabajo, así como sobre su vitalidad y fatiga, controlando previamente otras demandas y recursos laborales. En el estudio participaron un total de 171 profesionales de enfermería procedentes de España y 50 profesionales de Cuba (10.9% varones y 86.9% mujeres). Se realizaron análisis descriptivos, correlacionales, contraste de medias y análisis de regresión jerárquica. Los resultados revelaron que la flexibilidad psicológica explicaba una parte significativa de la varianza en las puntuaciones de vigor, vitalidad y fatiga, mientras que la atención plena explicaba de forma significativa una parte de la varianza del agotamiento emocional. Demandas laborales como la ambigüedad de rol y recursos laborales como la autonomía, también mostraron un efecto directo importante. Los resultados se discuten en términos de la importancia de incorporar estas variables en los planes de prevención y promoción de la salud dentro de las organizaciones sanitarias.
Wpływ zmian ustawy o planowaniu i zagospodarowaniu przestrzennymna lokalną politykę przestrzenną – studium przypadku gminy Rzgów
Authors: Rek Anna
Published: July 2018

Wprowadzone w 2015 roku zmiany w ustawie o planowaniu i zagospodarowaniu przestrzennym miały na celu racjonalizację lokalnej polityki przestrzennej. Wcześniej nie było regulacji prawnych jasno określających ile terenów gmina może przeznaczyć pod zabudowę. Skutkowało to wyznaczaniem coraz to nowszych terenów budowlanych, często bez zbadania rzeczywistych potrzeb i możliwości rozwoju. W efekcie stan ten doprowadził do zjawiska niekontrolowanej urbanizacji oraz wzrostu kosztów budowy infrastruktury technicznej i społecznej. Celem artykułu jest przedstawienie badań własnych nad oddziaływaniem wprowadzonych zmian w przepisach na lokalną politykę przestrzenną. W pracy przeprowadzono analizę rzeczywistych potrzeb i możliwości rozwoju gminy Rzgów, następnie zestawiono jej wyniki z lokalnymi uwarunkowaniami przestrzennymi w kontekście nowych regulacji prawnych.
Wykorzystanie technik GIS do wyznaczania obszarów kryzysowych na przykładzie miasta Żywiec
Authors: Majorek Agnieszka
Published: July 2018

Działania rewitalizacyjne stanowią jedne z priorytetowych zadań samorządów w Polsce, ponieważ dają szansę na wykorzystanie funduszy unijnych. Do podstawowych kroków procedury definiowania obszarów rewitalizowanych należy delimitacja pól podstawowych oraz analiza wskaźnikowa. Obecnie najczęściej wykorzystuje się do niej dane statystyczne oraz te pochodzące z konsultacji społecznych. Celem artykułu jest wskazanie technik GIS jako narzędzia umożliwiającego rozszerzoną diagnozę prowadzącą do wyznaczenia obszarów kryzysowych.
Ethical Standards in the Process of Counteracting Financial Abuse with Regard to EU Budget Funds. The Case of Poland
Authors: Walenia Alina
Published: July 2018

In accordance with the binding regulations of the EU law, each institution participating in the EU funds management process has in place relevant procedures preventing fraud and corruption and discouraging people from taking such actions. Managing institutions that work in cooperation with organisations which participate in the implementation of EU funds ensures the operation of an effective fraud risk management system and the implementation of effective anti‑fraud means which are designed to protect the financial interests of the European Union. The ethical norms and principles implemented in institutions which coordinate the process of EU funds management are of great importance for the process of reducing fraud related to EU funds. It was confirmed with the results of research carried out that clearly defined standards of employee conduct and determining procedures in the management and control system were the most important factors mitigating the irregularities. A special place was reserved for complying with the norms of ethical conduct and honesty by the employees of institutions managing the EU funds and development of a Code of Ethics which describes the conduct of the employees of institutions participating in the EU funds management process. The anti‑fraud procedures presented herein stem from EU law and are applicable in Poland.
Programy naprawy Rzeczypospolitej w czasach saskich Aspekty etyczno‑polityczne i społeczno‑ekonomiczne
Authors: Szymański Zdzisław
Published: July 2018

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Análise macrocomparativa da inovação ambiental (1990, 2000 e 2010)
Authors: Montenegro Rosa Livia Gonçalves , Britto Gustavo , Ribeiro Leonardo Costa
Published: July 2018

O objetivo principal do trabalho é compreender a influência e captar as configurações relacionadas ao meio ambiente e à tecnologia dos países desenvolvidos e em desenvolvimento que compõem a amostra, nos anos de 1990, 2000 e 2010. A base de dados consiste na utilização de fatores relacionados à atividade inovativa ambiental, ao grau de desenvolvimento econômico, às condições de infraestrutura, capacidade de produção de energia alternativa e nível de emissão de gases CO2 e à capacidade científica das nações. A metodologia aplicada aborda um método pouco explorado na literatura sobre inovação e meio ambiente: a técnica de análise qualitativa comparativa (QCA). Ao aplicar a técnica, para cada ano, os resultados fornecem uma análise de eventuais mudanças nas configurações específicas de cada país nesse intervalo temporal. Os resultados revelaram que as configurações que levam à inovação ambiental são representadas por boas condições de capacidade ambiental, científica e econômica.
Um apelo à prudência: conhecer e superar a marginalidade transcendendo as dualidades
Authors: Santos Eliane Tassi dos
Published: July 2018

Resenha do livro de Dermeval Saviani, Escola e Democracia.
Um modo de traduzir figuras do passado: cadernos de um professor catarinense
Authors: Souza José Edimar de
Published: July 2018

CUNHA, M. T. S.; SOUZA, F. de. F. Viver e escrever. Cadernos e escritas ordinárias de um professor catarinense (séc. XX). Florianópolis: Insular, 2015.Resenhado por: José Edimar de Souza