bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental Competence in Esports: The Mediating Role of Cognitive Flexibility in the Relationship Between Negative Problem Orientation and Social Problem Solving
Authors: Kilci Alp Kaan , Yalçıner Serhat , Bekir Seyhan
Published: January 2025

Background
Mental competence is essential for success in esports, where adaptability and problem-solving skills are critical. Cognitive flexibility supports these abilities by enabling gamers to handle dynamic environments and overcome challenges. Negative problem orientation, however, can hinder problem-solving and performance. This study investigates cognitive flexibility’s role in mediating the relationship between negative problem orientation and social problem-solving in esports.
Methods
The study participants were 966 esports players from Türkiye, classified as semi-professionals, professionals, and hardcore gamers. The data collection tools utilized in the study included the Negative Problem Orientation Questionnaire, the Social Problem-Solving Skills Inventory and Cognitive Flexibility Scale. SPSS PROCESS macro (Model 4) was used for data analysis, with bootstrapping methods applied to evaluate direct and indirect effects. This approach provided insights into the mediating role of cognitive flexibility in the relationship between negative problem orientation and social problem-solving.
Results
The mediation analysis indicated that cognitive flexibility plays a significant mediating role in the relationship between negative problem orientation and social problem-solving competence (indirect effect = 0.08, CI [0.0565, 0.1217]). The indirect effect suggests that negative problem orientation influences social problem-solving competence through cognitive flexibility. The direct effects were also significant, with negative problem orientation directly predicting social problem-solving competence (t = 5.56, p < .001) and cognitive flexibility having a strong positive effect on social problem-solving competence (t = 15.77, p < .001). The model accounted for 25% of the variance in social problem solving competence (R² = .25, F(2, 963) = 168.29, p < .001), demonstrating the importance of cognitive flexibility in enhancing an individual's adaptability and problem solving abilities in the e-sports context.
Conclusion
In conclusion, cognitive flexibility is a crucial role player between negative problem orientation and social problem-solving competence in esports. This mental skill enhances players' adaptability, problem-solving efficiency and ability to cope with stress, contributing to improved performance and psychological well-being. These findings highlight the importance of incorporating strategies to develop cognitive flexibility in the training and support of esport players.
Distance minimization data-driven method for nonlinear analysis of wooden beams
Authors: Dong Biao , Xu Guolin , Wang Xiangjian
Published: January 2025

Traditional calculation methods require constitutive models for analyzing the nonlinear response of structures. However, the wood constitutive models fail to accurately describe wood's mechanical behavior, resulting in low accuracy in the nonlinear response analysis of wood structures. This study attempted to apply a distance minimization data-driven method, which does not require constitutive models, to analyze the nonlinear response of wooden structures. Improve the distance minimization data-driven method by modifying the strain-displacement matrix assembly method and the stiffness matrix integration method; Build a wood material database based on tested mechanical parameters of C. Bambusaefolia wood. Three-point bending tests and nonlinear response analyses were performed on C. Bambusaefolia wood beams. The results showed that the method with sufficient accuracy could be applied to the nonlinear response analysis of wooden structures.
Comparison of the relationship between key demographic features and exercise levels across 22 countries
Authors: Lee Chung Gun , Kwon Elizabeth , Paltzer Jason , Okafor Chikwuemeka N. , VanderWeele Tyler J. , Johnson Byron R. , Choi Joo Hee
Published: January 2025

Background
The present study aims to examine global trends in exercise levels and explore the potential influence of demographic factors on exercise participation.
Methods
Using data from the Global Flourishing Study (GFS), which includes 202,898 participants from 22 geographically and culturally diverse countries, we assessed the average number of exercise days across various demographic groups (age, gender, marital status, employment, religious service attendance, education, immigration status) and across different countries.
Results
While the findings varied across the 22 countries, our analysis revealed that individuals aged 60 to 69, men, those in domestic partnerships, self-employed individuals, individuals with higher levels of education, frequent attendees of religious services, and those born in the country where the survey was conducted reported the highest mean number of exercise days.
Conclusions
These results contribute to a deeper understanding of the sociodemographic disparities in exercise participation. By documenting exercise patterns across key demographic groups and countries worldwide, this study provides valuable insights into the social determinants of exercise behavior.
Trends and Growth in ADHD Research: A Bibliometric Analysis of Indian Literature Indexed in Scopus
Authors: Kollamkandipalliyali Aswin , Kizhalath Sisira , Ragesh Gangadharan
Published: January 2025

Introduction: Attention-Deficit/Hyperactivity Disorder (ADHD) is a widely studied neurodevelopmental disorder with increasing research contributions from India. This study examines the impact of Indian ADHD research, focusing on publication growth, research trends, and resource impact. Using bibliometric methods, it identifies key institutions, authors, funding agencies, and current research trends shaping the field.
Methods: Data for this study were sourced from the Scopus bibliographic database, retrieving 721 documents affiliated with India. Bibliometric analysis was conducted using the bibliometrix R package. Bradford's Law was applied to identify core journals, Lotka's Law was used to assess author productivity, and keyword analysis was used to determine prevalent research themes.
Results: India is a leading contributor to ADHD research, with the highest publication count in 2023. Approximately 36.1% of research publications on ADHD are within medicine. The National Institute of Mental Health and Neurosciences (NIMHANS) emerged as the most productive institution, while Prof.Sinha was identified as the most prolific author. The Indian Council of Medical Research (ICMR) was the top funding agency. Bradford’s Law revealed 21 core journals publishing ADHD research, and keyword analysis highlighted contemporary research themes.
Conclusion: This study highlights India's significant role in ADHD research, driven by contributions from key institutions, prolific authors, and robust funding. Identifying core journals and emerging research trends offers valuable insights for future research directions in this field.
Rechtsformen für die Nachhaltigkeit
Authors: Zeidler Cora
Published: January 2025

Der Beitrag befasst sich mit drei Gesellschaftsformen für soziale und/oder ökologisch orientierte Unternehmen, die einen Beitrag zu einem ökologisch-nachhaltigeren Gesellschaftsrecht leisten sollen. Es werden die US-amerikanische Rechtsformvariante benefit corporation, der französische gesetzliche Status société à mission und die britische Rechtsformvariante community interest company dargestellt, auf Sinnhaftigkeit der Zwecksetzung und auf die Effektivität vorgesehener Kontrollmechanismen vergleichend analysiert und vor dem Hintergrund, ob sie tatsächlich einen Beitrag zur Bekämpfung des Klimawandels leisten können, bewertet.
As tecnologias da informação e comunicação e o lúdico associado ao processo de ensino-aprendizagem
Authors: COCATI Letícia Costa Dias , ALVES Alex Roddan Marta
Published: January 2025

O trabalho focou na utilização do ChemSketch® para a criação de jogos educativos em Química, destinados principalmente a alunos do Ensino Médio. Os objetivos abrangeram a capacitação no uso do software, o desenvolvimento de jogos como memória e quiz e a divulgação através de redes sociais. O público-alvo consistiu em aproximadamente 38 discentes/docentes participantes dos jogos e em torno de 200 seguidores na página quimicagame. Teve-se resultados favoráveis em relação à Sala de Jogos, podendo ser observado através de questionário aplicado aos docentes/discentes, que acharam ótimo em relação à aplicação da teoria e conceito do assunto, a troca de informação e a relação entre professor-aluno, aprendizado do aluno relacionada ao conteúdo de química e interação dos alunos-alunos. Ademais, docentes e discentes não mudariam a Sala de Jogos, gostariam que na sua escola também tivesse uma, e apenas 10 conheciam a página do Instagram. Ao final, observou-se uma dinâmica incentivadora, de motivação e aprendizado.
The Epicurean and Leviathan: The Practical Ethics of Ernst Jünger
Authors:   V. I. Vernadsky Crimean Federal University, Karabykov Anton V.
Published: January 2025

The purpose of the article is to explore the fundamentals of practical ethics which was developed by the famous German intellectual and fiction writer Ernst Jünger (1895–1998) and reflected in his autobiographical prose. The analysis focuses on the period of his life and work marked by intense moral reflection – the tragic decade that began before the Second World War and ended with the occupation of West Germany by the victorious states. It is proved that the form of ethics that Jünger cultivated throughout his earthly journey most corresponds to the Epicurean scheme. This is evidenced by its general vector aimed at achieving the serenity and quiet joy bestowed by life as well as the main issues which are solved in it. These issues include the reasonable ordering and control of sensual desires and fears. In connection with the general direction of Jünger’s ethics, the concept of inner emigration turned by the thinker into a consciously Epicurean way of life is discussed. The main attention is paid to the innovations that Jünger brought to this scheme. Their predominantly Christian character is substantiated. Instead of conceptual analysis and along with autogenic training (both are the core of the Epicurean “healing of the soul”), the thinker practiced Christian asceticism in relation to desires and belief in immortality against the fear of possible destruction. The conflict between Epicurean (“Live unnoticed”) and predominantly Christian (“Live with dignity”) moral attitudes that is manifest in Jünger’s life and thoughts at that dramatic time is also considered. It is shown that he resolved this conflict in favor of the second attitude – even if not always in practice, but invariably at the level of beliefs.
The Collective Suicide of Peasants of the Spasovite Covenant in the Era of Nicholas I: Micro-historical Analysis
Authors:   Vladimir State University named after Alexander and Nikolay Stoletovs, Khizhaya Tatiana I.
Published: January 2025

The article analyses and contextualizes a case of mass suicide of the Russian peasants-Spasovites in the village of Kopeny, Saratov province in 1827. The work is based on unpublished archival documents: records of several court cases, as well as officials’, ethnographical and clerical researches of the Saratov Old Believers. To get as complete picture on the tragedy as possible, the author draws on materials presenting a background of the event. The paper attempts to clarify the motives behind the collective suicide, religious practices related to it, and seeks to expand our knowledge of the little-studied Spasovite movement and of the government discourse regarding religious dissidents in the early reign of Nicholas I. The causes of the suicide are identified as multi-faceted. Underlying eschatological views and soteriological ideas according to which death was thought of as a way to expiate sins were influential. This was layered with anxiety and traumatic experiences connected with the local social context: the expectation of future persecution against the Spasovites’ beliefs, as well as fear and indignation caused by the crimes of the village authorities. The sources present diverse suicide practices used by Spasovites in the early 19th century, unusual details of these practices, and discourse of tolerance and leniency towards sectarians – along with repressive one – in the official rhetoric. The investigation into the suicide had wide-ranging consequences, acting as a motivation and occasion for the local authorities to develop and implement severe measures against all Old Believers, including Popovtsy.
Ob’’yavit’ v narod / Announce to the People: About Speech Formulas with Meaning ‘Bringing to Attention’ in Printed Decrees of Peter I (1714–1719)
Authors:   St. Petersburg State University, Sadova Tatiana S.
Published: January 2025

The article describes the language of administrative documents created during the period of the most active reform activity of Peter I (1714–1719), during which more than 110 printed decrees were issued with tsar’s direct participation. The focus is on stable combinations with the meaning of ways of bringing the sovereign’s decree orders to the attention of the population. Their historical, cultural, and substantive value is emphasized, since they often testify to those extra-linguistic reasons that determined the formation of a corpus of stable combinations, designated in modern business language by the terms “cliche,” “formula,” etc. Thus, imperative infinitive combinations often include verbal words with the root pechat- / print- (pechatat’, pechatano / print, printed), the two-word nomination “pechatnyy list” / “printed sheet” or one-word “list” / “sheet” becomes extremely frequent, imperative structures “pribit’ listy”, “rozdat’ listy” / “to nail sheets”, “to distribute sheets” — all this reflects the total transition of Peter’s office to printed document form. The lexical and syntactic stability and frequency of selected combinations in the texts of decrees can be traced, which allows one to speak of them as formulaic combinations or genre formulas, the formation of which during this period becomes a striking feature of the new official language. It is indicated that printed decrees significantly speed up the delivery of the sovereign’s will to the most remote provinces of Tsarist Russia, to the widest circle of people, as evidenced by the formulaic combinations “dlya vsenarodnogo vedoma”, “dlya vsyakogo vedoma”, “dlya vsenarodnogo ob”yavleniya” / “for public knowledge”, “for all knowledge”, “for public announcement”, etc. When considering the extremely frequent formulaic combination “ukazy poslany” / “decrees have been sent”, it is emphasized that the lack of subjectivity of official communication, which is reflected in this form, subsequently becomes one of the main features of state official communication, characteristic of modern documentary language.
The Russian Word milost’ in the Light of Language Corpora (Including Parallel Ones)
Authors:   0000-0002-9713-8166, Kabanova Oksana V.
Published: January 2025

The article is devoted to the linguistic properties of the Russian noun milost’. The aim is to present the properties of this word, using corpus data, including parallel corpora. The research methods include the analysis of dictionary definitions, a monofocal approach, and the shuttle method. The word milost’ has a debatable word-formation meaning. It does not mean the property of a nice person, so its word-formation meaning does not match its word-formation model. The frequency of the word milost’ decreases over time. In fiction its frequency is almost twice as high as in non-fiction texts. Among non-fiction texts it appears most often in church and theological literature and least often in production and technical literature. The word milost’ has two modes of use, which have different translations and stimuli in parallel corpora. In some cases its meaning is unclear. Grammatically, the two modes of use of milost’ differ in both languages. For example, when milost’ indicates a kind attitude, in English it corresponds to words without an article or with a definite article. If it indicates a specific good deed, then it corresponds to words with the indefinite article in English. Stable phrases with the word milost’ often have meanings not directly connected with its main meaning, ranging from polite forms to ironic phrases. The variety of translations and contexts for milost’ suggests its high linguistic specificity.
Difficulties in Developing Russian Phonetic Skills among the Students from Myanmar when Learning the Russian Language and the Ways of Overcoming Them
Authors:   RUDN University, Thida Hnin , Kunovski Marina N. ,   RUDN University
Published: January 2025

In the Republic of the Union of Myanmar, much attention is paid to the study of the Russian language within the framework of higher education programs, interest in which among the Myanmar youth is steadily growing with the expanding opportunities for cooperation between the two countries. The presented study is devoted to the problem of teaching phonetics in the absence of a Russian-speaking environment and identifying the causes of difficulties in its acquisition. This issue seems relevant, since the formation of phonetic skills can have a significant impact on the process of learning the Russian language, and phonetic errors can naturally complicate the acquisition of vocabulary and lead to a violation of understanding. The purpose of the study is to analyze and describe the most common errors that native speakers of the Burmese (Myanmar) language make when mastering the phonetics of the Russian language, as well as the causes of these errors. Based on the work of methodologists and researchers, a brief comparative description of the Russian and Burmese (Myanmar) languages in terms of phonetics is provided; an analysis of the difficulties in forming phonetic skills in students from Myanmar when learning Russian outside the natural Russianspeaking environment is given. In connection with the need to improve the effectiveness of teaching Russian phonetics, the issue of developing digital educational resources is addressed that are maximally focused on the specifics of the Burmese language and the needs of the target audience — students of Myanmar — and at the same time consider the peculiarities of teaching Russian outside the Russian-speaking environment and the established educational traditions of Myanmar.
Desenvolvimento e produtividade de espécies florestais em diferentes regimes de irrigação no semiárido brasileiro
Authors:   , Silva Ana Karla Vieira da
Published: January 2025

A demanda nacional por madeiras foi intensificada nas últimas décadas, portanto, surge a necessidade de atender demandas regionais para estimular o aumento da produtividade de plantios florestais em regiões anteriormente pouco expressivas. O objetivo do presente estudo foi avaliar a produtividade de espécies florestais nativas, exóticas e clones de Eucalyptus em diferentes regimes de irrigação no Semiárido brasileiro. O estudo foi conduzido em um plantio experimental, mantido entre março de 2011 e novembro de 2021, em um lote do Perímetro Irrigado do Baixo Acaraú, inserido entre as cidades de Acaraú e Marco, Ceará, Brasil. No ano de 2021, indivíduos de quatro espécies de árvores nativas, cinco espécies de árvores exóticas, além de cinco clones de Eucalyptus sp. foram mensuradas com idades de aproximadamente 11 anos. Para cada espécie ou clone, foram abatidas seis árvores, nas duas áreas submetidas aos dois diferentes regimes de irrigação (irrigado até 12 meses após o plantio; e irrigado até 36 meses após o plantio). Após a seleção, foi contabilizada a mortalidade e realizada a obtenção das variáveis dendrométricas: altura total e comercial, diâmetro à altura do peito, áreas transversal e basal, volume do fuste, volume total, fator de forma e incremento médio anual do volume de madeira produzido. Dentre as espécies nativas, H. impertiginosus e A. colubrina apresentaram a maior produtividade em crescimento e volume de madeira. Para as espécies exóticas, destacaram-se A. mangium e S. foetida. Quanto aos clones de Eucalyptus sp., o melhor desempenho em produtividade foi observado para os clones VE 41 (E. urophylla x E. grandis) e VE 38 (E. urophylla x E. camaldulensis), quanto a maior resistência e adaptabilidade, ressalta-se o cone GG 680 (E. urophylla x E. grandis). O regime de irrigação por até 12 meses após o plantio mostrou-se suficiente para o estabelecimento e crescimento das árvores avaliadas.
Fidelidade de habitat de botos-cinza (sotalia guianensis) em uma área marinha protegida no Nordeste do Brasil
Authors:   , Silva Gessica Rafaelly Dantas da
Published: January 2025

O boto-cinza, Sotalia guianensis, é um pequeno cetáceo associado a baías, enseadas e estuários, que atualmente encontra-se ameaçado de extinção em todo o território nacional. Informações populacionais sobre esta espécie ainda são raras ou imprecisas para muitas regiões e têm dificultado o conhecimento sobre seu status de conservação, a nível internacional. Com o intuito de contribuir com informações populacionais e subsidiar estratégias de conservação de botos-cinza, este estudo buscou investigar: a fidelidade de habitat e de botos-cinza na Reserva de Fauna Costeira de Tibau de Sul e o uso desta área protegida como possível área berçário. Neste estudo, nós utilizamos dados de fotoidentificação, obtidos de 2013 a 2019, durante 84 dias de coleta de dados, totalizando sete anos de amostragem. As fotos de nadadeira dorsal de botos-cinza foram realizadas com o auxílio de uma câmera fotográfica acoplada a uma lente telescópica 150-600mm e um monopé, a partir de uma faixa elevada na praia, para evitar alterações comportamentais nesses animais. De um total de 45 botos-cinza fotoidentificados, 10 botos-cinza apresentaram fidelidade de habitat intermediária e 2 botos-cinza apresentaram alta fidelidade de habitat, sendo registrados em três ou mais anos de amostragem, enquanto outros 33 botos-cinza foram considerados visitantes ocasionais, registrados em apenas um ou dois anos de amostragem. Nós fotoidentificamos 17 botos-cinza na companhia de filhotes. Grupos de botos-cinza apresentaram tamanho médio (± EP) de 2,4 ± 0,08, variando de 2 a 5 indivíduos (n = 98). Filhotes estiveram presentes em 35,8% dos registros. A Reserva de Fauna Costeira de Tibau do Sul se mostrou uma importante área de concentração de botos-cinza, utilizada inclusive para cuidado parental da espécie no Brasil, necessitando de medidas urgentes para garantir a sua conservação, em um cenário atual de intensa exploração turística.
Potencial ecotoxicológico e atividade antihelmíntica in vitro de cnidoscolus quercifolius pohl (euphorbiaceae) sobre nematoides gastrintestinais de ovinos
Authors:   , Felix Renata Cristinne da Silva
Published: January 2025

A criação de pequenos ruminantes no Brasil é considerada uma atividade rentável e
promissora no campo da agropecuária. Porém, a criação dos rebanhos é dificultada devido às
doenças parasitárias que acometem os animais. Os antiparasitários químicos comercializados
são o meio mais rápido e prático de controlar as parasitoses gastrintestinais; contudo, os erros
de manejo, o uso excessivo desses anti-helmínticos e as condições climáticas da região
favorecem o desenvolvimento da resistência parasitária. Com isso, uma alternativa ao
tratamento químico é a fitoterapia, onde destaca-se a espécie Cnidoscolus quercifolius (Pohl),
utilizada popularmente na cicatrização de ferimentos, contra dores e inflamação, além de ação
diurética, porém ainda sem efeito comprovado contra os parasitos. Assim, o objetivo do
estudo foi analisar in vitro a ação ovicida e a ecotoxicidade do extrato aquoso obtido a partir
das folhas de C. quercifolius e, analisar os componentes fitoquímicos da folha. Para isso,
cinco coletas de amostras fecais foram realizadas em pool amostral de 10% de um rebanho
ovino. Posteriormente, realizou-se o teste de eclodibilidade, a partir da técnica de recuperação
de ovos nas fezes animais, seguido da análise da ecotoxicidade aguda em espécies de
microcrustáceos Daphnia magna e do teste fitoquímico das folhas. Os resultados mostraram
que o extrato possui atividade inibitória sobre a eclosão dos ovos, apresentando 100% de
inibição em todas as concentrações utilizadas (10%, 5%, 2,5% e 1,25%). Quanto ao ensaio de
ecotoxicidade aguda, o extrato de C. quercifolius apresentou-se tóxico, imobilizando 100%
dos organismos nas quatro concentrações testadas, tornando desnecessário a realização do
teste crônico. Na análise fitoquímica, foi comprovada a presença de fenóis, flavonóides,
taninos condensados, saponinas, alcalóides e triterpenos, o que pode estar relacionado com a
ação ovicida do extrato. Assim, concluiu-se que o extrato aquoso de C. quercifolius apresenta
atividade antiparasitária e possui metabólitos secundários de ação comprovada, no entanto,
mostrou-se tóxico. Portanto, o extrato aquoso obtido das folhas de C. quercifolius necessita de
estudos em concentrações menores, que reduzam a sua ecotoxicidade e encontrem uma dose
eficaz para o tratamento dos pequenos ruminantes.
Eficiência de blendas poliméricas de fécula de mandioca e quitosana com extrato da semente de uva em parâmetros de qualidade do camarão refrigerado
Authors:   , Costa Bárbara Jéssica Pinto
Published: January 2025

Os frutos do mar são alimentos com grande valor nutricional e importância econômica,
porém podem sofrem uma rápida degradação no processo de post mortem. O armazenamento
correto pode impedir o desenvolvimento de microrganismos e reações indesejáveis no camarão,
como mudança de pH, coloração, acidez e outros. Hoje, um dos métodos mais tradicionais de
conservação do camarão é a aplicação de frio, porém esse método nem sempre é suficiente para
conservar de forma eficiente. A praticidade na hora do consumo após o seu processamento
oferecido ao consumidor e a qualidade de produtos minimamente processados vem ganhando
espaço no mercado, associado com o desejo de reduzir o consumo de embalagens de plásticos
convencionais. Os biopolímeros podem ser obtidos através de polissacarídeos, vias
microbianas, biomassa ou monômeros, e juntamente com as possibilidades de combinações
entre eles e outros componentes utilizados para o desenvolvimento de revestimentos prolongam
o tempo de validade de produtos alimentícios, resultando muitas vezes em um alimento com
qualidade em aspectos físico-químicos e microbiológicos. Assim, esse trabalho teve por
objetivo estudar a combinação de dois biopolímeros, fécula de mandioca e quitosana, essa
combinação de biopolímeros é chamada de blendas poliméricas, incorporadas com extrato da
semente de uva aplicadas nos camarões pelo método refrigerado durante seis dias de
armazenamento. Inicialmente, foram feitos os revestimentos de acordo com o delineamento
experimental e, após preparo das soluções filmogênicas, essas foram aplicadas nos camarões,
que ficaram acondicionados em regrigeração a 7±1°C durante seis dias de armazenamento. Para
avaliar a qualidade do camarão, foram realizadas análises microbiológicas e físico-químicas
nas amostras de camarões e quanto aos revestimentos foram produzidos filmes pelo método
casting e realizado caracterizações nos filmes para entender melhor as propriedades dos filmes.
Caracterização microbiológica, parasitológica e físico-química de molhos comercializados em lanchonetes
Authors:   , Carvalho Francisco Sérvulo de Oliveira
Published: January 2025

Com o consumo crescente de alimentos ofertados pelo serviço rápido de alimentação,
popularmente conhecido como fastfood, é importante uma atenção especial quanto a
possibilidade de transmissão de doenças de origem alimentar aos indivíduos no decorrer do
processo de ingestão, isso devido as falhas que possam ocorrer no processo de manipulação,
higienização, e falta de controle sanitário de alguns estabelecimentos. Os molhos artesanais,
caracterizam-se como alimentos que oferecem sabor diferente do convencional encontrado na
indústria. Dessa forma, o objetivo do projeto foi realizar análises microbiológica, parasitológica
e físico-química dos molhos comercializados em lanchonetes da cidade de Mossoró, estado do
Rio Grande do Norte. O critério de inclusão foi a venda de alimento associado/acompanhado
ao molho artesanal. Dessa foram selecionados aleatoriamente estabelecimentos com
localizações distintas. Foram coletadas amostras de sete estabelecimentos (A1, A2, A3, A4, A5,
A6, A7), com três repetições por dia de avaliação de cada estabelecimento, perfazendo um total
de 63 amostras. Estas foram, imediatamente, transportadas ao laboratório onde foram
submetidas a análises no mesmo dia da coleta e também após 3 e 6 dias. Foram realizadas
avaliações microbiológicas, parasitológicas e físico-químicas. Os dados obtidos nas avaliações
microbiológicas e físico-químicas foram analisados com o teste de análise de variância
(ANOVA) e o teste de Tukey ao nível de 5% de significância. Com os testes microbiológicos
aplicados para coliformes a 35°C e a 45°C, e E. coli, bactérias mesofilos, Bolores e Leveduras,
foi possível detectar a presença dos microrganismos em 4/7; Staphylococcus foi detectado em
3/7; e a presença de Salmonella se mostrou ausente em todas as amostras. Não foi detectada
presença de parasitas. E nas análises físico-químicas, foi possível observar uma leve perda na
acidez dos molhos durante os dias de armazenamento sob refrigeração. Dessa forma, pode-se
concluir que é necessário a aplicação de avaliações das condições higiênico sanitária nos
estabelecimentos com uma regularidade, de forma a garantir a segurança alimentar dos
consumidores.
Ecofisiologia de sementes de Enterolobium contortisiliquum (Vell.) Morong
Authors:   , Maia Juliana Holanda
Published: January 2025

Enterolobium contortisiliquum (Vell.) Morong, mais conhecida como timbaúba, é uma
espécie nativa do Brasil com grande importância econômica, social e ambiental. Este
trabalho teve como objetivo avaliar a presença de dormência após o armazenamento das
sementes e os métodos de superação, além do efeito de diferentes temperaturas e do
condicionamento fisiológico em sementes submetidas ao estresse salino. Para isso, foram
realizados três experimentos, sendo o primeiro com três tratamentos para superação de
dormência (escarificação em lixa n. 80, ácido sulfúrico por 60 minutos e testemunha) em
dois lotes de sementes de timbaúba coletados nos anos de 2014 (seis anos após colhido)
e 2015 (cinco anos após colhido), acondiciondos em garrafas de plástico e armazenados
em ambiente controlado (17°C; 40% UR) até a realização do experimento. O
delineamento experimental foi o inteiramente casualizado em esquema fatorial 2x3 (lotes
x métodos de superação de dormência), com quatro repetições de 25 sementes. A
germinação das sementes foi avaliada aos 14 dias. No segundo experimento, as sementes
previamente escarificadas, foram semeadas em substrato tipo rolo de papel,
acondicionadas em sacos plásticos e colocadas em estufa de germinação sob as
temperaturas de 20, 25, 30 e 35°C com fotoperíodo de 8 horas. O delineamento
experimental foi o inteiramente casualizado, com quatro repetições de 25 sementes.
Avaliou-se a primeira contagem, germinação, comprimentos da parte aérea e raiz, massa
seca da parte aérea e raiz. O terceiro experimento foi dividido em duas etapas: a primeira
foi a caracterização da curva de absorção de água pelas sementes de timbaúba em
diferentes potenciais hídricos. A segunda, etapa realizou-se em delineamento
experimental inteiramente casualizado em esquema fatorial 4 x 4, sendo quatro tipos de
condicionamento das sementes (hidrocondicionamento por 48h, osmocondicionamento a
-0,4 MPa por 72h, osmocondicionamento a -0,8 MPa por 96h e sementes nãocondicionadas) em quatro níveis de salinidade (0; 6; 12 e 18dS.m-1
) simulado com
soluções de cloreto de sódio, com quatro repetições de 25 sementes. Não foi observada
redução da intensidade de dormência dos lotes armazenados (2014 e 2015), sendo
necessário realizar a superação de dormência para uma germinação mais rápida e
uniforme. O ácido sulfúrico por 60 minutos e a escarificação em lixa são eficientes na
superação de dormência de sementes de timbaúba. A germinação das sementes de
timbaúba é favorecida pelas temperaturas de 20, 25, 30 e 35°C, porém, o crescimento das
raízes das plântulas é prejudicado a 35°C. O aumento da salinidade não afetou a
germinação das sementes, porém prejudicou o crescimento das plântulas, principalmente
das sementes sem condicionamento.
Tolerancia e capacidade remediadora de macrofitas aquáticas ao atrazine
Authors:   , Hernandez Maria Carolina Ramirez
Published: January 2025

O atrazine é um herbicida utilizado para controle de plantas daninhas em vários países.
O uso desse herbicida em grande escala, associado à elevada capacidade de sua molécula em
lixiviar no solo, tem proporcionado o acúmulo de resíduos nos corpos de água superficial e
subterrânea podendo causar impacto em organismos presentes nestas áreas. Neste trabalho
avaliou-se a tolerância e a capacidade remediadora de macrófitas aquáticas flutuantes comuns
no Brasil ao herbicida atrazine. Os experimentos foram conduzidos em casa de vegetação, no
delineamento inteiramente casualizado, com quatro repetições. As espécies de macrófitas
aquáticas utilizadas no experimento foram: salvinia (Salvinia minima D.Mitch), aguapé
(Echhornia crassipes Mart.Solms) e alface d’água (Pistia stratiotes L.). Inicialmente foi
avaliada a tolerância das três espécies a cinco concentrações de atrazine (0, 2, 20, 200, 1000
µg L-1) durante 15 dias. Após esse período, a tolerância das macrófitas ao atrazine foi avaliada
pelos níveis de intoxicação visual das plantas, a produção de biomassa, área foliar,
comprimento de raiz, matéria seca, clorofila e açúcares. No segundo experimento, as plantas
foram cultivadas em água contaminada com 2 µg L-1 e 20 µg L-1 avaliou-se, durante 15 dias, a concentração do herbicida na solução por meio de cromatografia líquida de ulta eficiência. Todas as espécies apresentaram sintomas de intoxicação após 9 dias da exposição. A atrazina
reduziu o crescimento, causou intoxicação e variação na clorofila. Verificou-se que a
sensibilidade varia para cada espécie e os resultados indicaram que as macrófitas apresentam
sensibilidade diferencial ao atrazina e em concentrações superiores a 200 µg L-1 são letais a S.
mínima e E. crassipes. No segundo experimento ss concentração da atrazina na água para o
dia final do experimento diminuiu um 60, 58% para a espécie S. mínima nas concentrações 2
e 20 L-1 , 60 e 50 % para P. stratiotes e um 70 e 50 % para E. crassipes. Os resultados
indicaram que estas espécies podem ser utilizadas como fito remediadoras em concentrações
menores a 200µg L-1 de Atrazina, apresentando intoxicação em concentrações superiores.
The Unity and Distinction of the Missions of the Son and the Holy Spirit in the Pneumatological Christology of Yves Congar
Authors:   The Society of Theology and Thought, Ha Sunghun Joseph
Published: January 2025

Cardinal Yves Congar(1904-1995) was to have a significant influence on the Council of Vatican II in the areas of ecclesiology and ecumenism. During this council he was engaged with theologians from the Eastern Churches. Flowing from this dialog, he discerned that the area of pneumatology in Latin theology was undeveloped, and therefore leaving something lacking.
Congar partially agreed with the criticisms of Eastern theologians including Vladimir Lossky. Lossky criticized Western theology of this observed weakness in pneumatology, due to the doctrine of the Filioque. Beyond this, Congar sought to avoid the perception of a unilateral dependence between the Son and the Holy Spirit. To achieve this, he spoke of a “free sector“ for the Holy Spirit in relation to the Son, thus emphasizing the unique role of the Holy Spirit. However, this idea faced criticism as it seemed to separate the Son from the Holy Spirit. Later, Congar developed his pneumatological Christology by highlighting the unity between the Son and the Holy Spirit, particularly referring to St. Paul's words, “The Lord is the Spirit” (2Cor, 3:17). This new idea is expressed in his trilogy on the Holy Spirit (Je crois en l’Esprit-Saint), especially in La Parole et le Souffle (1984). In this study, he emphasized that the glorified Christ is filled with the Spirit and becomes the pneumatized Christ (le Christ pneumatisé); thus, He acts as the Spirit and through the mode of the Spirit. Their actions cannot be distinguished. We believe that Congar's journey regarding the relationship between the Son and the Spirit is intimately linked to the two fundamental principles of Trinitarian theology: unity and distinction.
In this research, it has been examined whether Congar's pneumatological Christology indeed establishes a relationship of unity and distinction between the Son and the Holy Spirit.
Evaluation and Prospects for the Study of ‘Jesus Christ as the Sole Mediator of Salvation’ : Focusing on the Context of Asia and Korea
Authors:   The Society of Theology and Thought, Han Mintaeg
Published: January 2025

“Why is Christ the sole mediator of salvation?” This paper aims to critically examine this question and probe an answer. The consistent profession of Christian faith regarding the uniqueness and universality of salvation mediated through Christ leads to tensions in the context of the contemporary multi-religious environment and inter-religious dialogue. This paper does not merely defend this statement from an apologetic perspective but intends to critically examine the theological positioning of the question, highlight new issues arising from the unique contexts of Asia and Korea, and explore potential answers.
First, this paper outlines the changes in the Catholic Church's attitudes toward other religions since the Second Vatican Council, along with the evolving theological questions that have emerged thereof. This allows us to have a close look at the Church's official position on the uniqueness and universality of salvation through Christ, explore various theological efforts, and assess the current state of the issue in the context of inter-religious dialogue.
Next, this paper examines how the issues of inter-religious dialogue and religious pluralism arise in the religious context of Asia, particularly in Korea, and intends to identify their unique characteristics. The purpose of this is to explore the ways to navigate inculturation and inter-religious dialogue in the face of challenges such as religious relativism, syncretism, and 'religious double belonging.' Specifically, this paper proposes new solutions by examining recent studies on the concept of ‘natural knowledge of God.’
The final chapter proposes a new way of presenting the uniqueness and universality of salvation through Christ within Asia's multi-religious context, using the concept of mercy (misericordia), which can be understood in terms of empathy and compassion. This chapter particularly draws on Cardinal Kasper's theology of mercy and Keenan's theological reflections on vulnerability. It shows how mercy, understood in terms of vulnerability, can renew Christian identity in a multi-religious context, promote dialogue and encounter with other religions, and inspire participation in the journey toward a better world. Furthermore, it seeks to clarify how the uniqueness and universality of salvation through Christ can establish a healthy and critical relationship with other religions without preventing conversations with them or resorting to syncretism. A reflection on Pope Francis' pastoral approach to mercy provides an opportunity to clarify the assumption presented in this paper.
Exploring the Therapeutic Potential of Plumbagin: Its Current Applications in Cancer and Neuropsychiatric Disorders
Authors: Jiang Tingting , Zhou Dongsheng , Wang Jiahui , Huang Haitao , Zhang Chong , Yan Jianguo , Zhou Yali
Published: January 2025

Plumbagin (PL) is an important natural active ingredient in traditional Chinese
medicine derived from the Plumbago zeylanica L. It possesses a variety of biological
activities, such as anti-inflammatory, anticancer, antioxidant, antimicrobial, and neuroprotective
properties, and has great potential for utilization in disease treatment and
prevention. Cancer and neurological and psychiatric diseases are two major categories
of diseases that currently threaten the physical and mental health of human beings, and
their increasing incidence is causing a serious economic burden to all humanity. Based
on the physical and chemical properties and pharmacokinetics of plumbagin, this study
will focus on summarizing the application research status of plumbagin in cancer, neurological,
and psychiatric diseases and analyze the molecular targets and action pathways
of its therapeutic efficacy. This study will also briefly summarize the application of
plumbagin in other diseases, as well as the existing problems and future development direction
of plumbagin in clinical application, aiming to provide new perspectives and
strategies for the development of new drugs and the treatment of existing diseases.
A Fed-batch Process for the Production of Recombinant Adeno-Associated Virus (rAAV) Vectors Using the Sf9-Rhabdovirus-Negative Cell Line
Authors: Li Xinran , Gu Jieyi , Wu Haoquan , Xie Yuanyuan
Published: January 2025

Background:

Gene therapy has been effectively applied in many biological studies
and for the treatment of many genetic or cancer diseases. Currently, Recombinant Adeno-
Associated Viruses (rAAVs) are one of the main types of delivery vectors used for gene therapy.
rAAV vectors produced via the Sf9 cells have the advantages of high rAAV yields, easy scaleup,
and low cost.

Method:

Here, we used Sf9 rhabdovirus-negative (Sf9-RVN) cells to validate and optimize the
rAAV production process, and the fed-batch process increased the rAAV production titre.

Results:

In the fed-batch procedure, the cell density reached 12.9×106 cells/mL, which was approximately
twice as high as in the batch culture process. The rAAV titre was also approximately
8-fold higher in the fed-batch process, reaching 1.5×1012 VG/mL. The optimized process was
validated by generating rAAVs with various serotypes and genes of interest (GOI), all of which
gave production titres greater than 1×1012 VG/mL.

Conclusion:

We used Sf9-RVN cells to develop a fed-batch rAAV production process that replaces
Sf9 cells to meet regulatory standards. This process has good applicability, and the rAAV
titre can reach at least 1×1012 VG/mL, which is higher than the level of 1011 VG/mL reported in
the literature.
Effective Synthesis of Dopamine Dimer
Authors: Dejun Zhou , Yuying Zhang , Xiaoyue Liu , Huachuan Zheng
Published: January 2025

Background:

Dopamine (1) is a commonly used vasopressor, primarily employed to
treat various types of shock, congestive heart failure, and acute renal failure. Dopamine dimer (2) is
an impurity generated during the production process of dopamine raw materials or the metabolism
of dopamine drugs themselves.

Methods:

This article presents an effective method for synthesizing dopamine dimer through the
condensation of methyl 3,4-dimethoxyphenyl acetate (4) and 3,4-dimethoxyphenylethyl amine (5),
followed by reduction and demethylation.

Results:

The product was synthesized from easily accessible raw materials, achieving a total yield
of 48% over five steps.

Conclusion:

This synthesis method is simple and beneficial for pharmaceutical companies to adopt
and implement.
Advances in Structural Types and Pharmacochemistry of CDK12
Inhibitors
Authors: Wang Dan , Xia Ming-tao , Yan Jia-xin , Yu Ling , Li Shuai
Published: January 2025

Cyclin-Dependent Kinase (CDK) 12 is a member of the 20-membered CDK family
(CDK1-20) and plays a vital role in regulating gene transcription, mRNA splicing, translation, cell
cycle, and repair of DNA damage. CDK12 is an emerging therapeutic target due to its role in regulating the transcription of DNA Damage Response (DDR) genes in Cyclin-Dependent Kinase
(CDK). However, the development of selective small molecules targeting CDK12 has been challenging due to the high degree of homology between kinase domains of CDK12 and other transcriptional CDKs, most notably CDK13. So far, no CDK12 inhibitors approved by the US FDA
have been found, and more novel CDK12 inhibitors have been reported for the treatment of prostate cancer, breast cancer, ovarian cancer, lung adenocarcinoma, stomach cancer, cervical cancer,
etc. This review has attempted to summarize the structural characteristics and biological activities
of various novel CDK12 inhibitors reported since 2020. Meanwhile, we collated and analyzed the
reported CDK12 inhibitors from the perspective of structure, summarized the current clinical application potential of CDK12 inhibitors, and further analyzed their current challenges and future development trends.
Zeolite Nanoparticles: The Eco-Friendly Solutions for Environmental Contamination
Authors: Sisubalan Natarajan , Sivamaruthi Bhagavathi Sundaram , Kesika Periyanaina
Published: January 2025

This review highlighted the innovative utilization of zeolite Nanoparticles (NPs) in
various environmental applications, emphasizing their role in transforming waste materials into
valuable resources. Zeolite-confined metal NPs, particularly Palladium (Pd), exhibit enhanced
catalytic performance in the deep oxidation of light alkanes due to their unique interfaces
and protective zeolite structures. Developing electrospun membranes incorporating cellulose
acetate and nano-zeolites demonstrates promising potential for effective oil removal from
wastewater, achieving up to 97% separation efficiency. The synthesis of silver NPs from Tilapia
fish waste and their valorization within natural zeolites showcases an eco-friendly approach
for ammonia removal and antimicrobial applications. Integrating nano-silicon and
nano-zeolite treatments in combating salinity stress in medicinal plants highlights sustainable
agricultural practices. This review emphasizes the multifaceted benefits of zeolite NPs in addressing
urgent environmental challenges and promotes future research directions to optimize
their applications in pollution control and resource recovery. Prospects include scaling up production
methods, exploring novel composite materials, and investigating the long-term environmental
impacts of these nanomaterials to enhance their practical applicability in diverse settings.
Blockchain as a Prime Guardian: Securing Clinical Trial Data Integrity
Authors: Sethi Nikhil , Rathore Charul , Singh Dilpreet
Published: January 2025

The present study focuses on the possible use of the emerging technology of
blockchain in ensuring data management security in clinical trials. With the determination of the
chief researchers and clinical investigations becoming more and more complex and international,
achieving data quality and integrity, transparency, and legal compliance becomes imperative. By
offering a distributed and immutable time-stamped ledger, issues of data revisions, selective data
release, and the usually time-consuming issue of compliance auditing are well addressed. With
this technology, it is possible to conduct surveillance of multi-center studies without compromising the confidentiality of patients while allowing the researchers to have unbiased information.
When it comes to internal accountability, the use of the blockchain will create a situation whereby
no alteration of the documents will take place. Thus, regulatory oversight is improved with the engagement of these parties. In addition, it makes sure that the need for bias in the reporting of outcomes is avoided in all trials and all results reported whether positive or negative. In order to address clinical trial data management and clinical trial outcomes’ validity and reliability, this review provides reputation management through digital ledger technology in the real world.