bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunotherapy of Multiple Myeloma: Current Status as Prologue to the Future
Authors: Abramson Hanley N.
Published: October 2023

The landscape of therapeutic measures to treat multiple myeloma has undergone a seismic shift since the dawn of the current century. This has been driven largely by the introduction of new classes of small molecules, such as proteasome blockers (e.g., bortezomib) and immunomodulators (e.g., lenalidomide), as well as by immunotherapeutic agents starting with the anti-CD38 monoclonal antibody daratumumab in 2015. Recently, other immunotherapies have been added to the armamentarium of drugs available to fight this malignancy. These include the bispecifics teclistamab, talquetamab, and elranatamab, and the chimeric antigen receptor (CAR) T-cell products idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel). While the accumulated benefits of these newer agents have resulted in a more than doubling of the disease’s five-year survival rate to nearly 60% and improved quality of life, the disease remains incurable, as patients become refractory to the drugs and experience relapse. This review covers the current scope of antimyeloma immunotherapeutic agents, both those in clinical use and in development. Included in the discussion are additional monoclonal antibodies (mAbs), antibody–drug conjugates (ADCs), bi- and multitargeted mAbs, and CAR T-cells and emerging natural killer (NK) cells, including products intended for “off-the-shelf” (allogeneic) applications. Emphasis is placed on the benefits of each along with the challenges that need to be surmounted if MM is to be cured.
Early Depletion of Neutrophils Reduces Retinal Inflammation and Neovascularization in Mice with Oxygen-Induced Retinopathy
Authors: Deliyanti Devy , Suphapimol Varaporn , Ang Phoebe , Tang Xiuying , Jayasimhan Abhirup , Wilkinson-Berka Jennifer L.
Published: October 2023

Retinal inflammation is a central feature of ocular neovascular diseases such as diabetic retinopathy and retinopathy of prematurity, but the contribution of neutrophils to this process is not fully understood. We studied oxygen-induced retinopathy (OIR) which develops in two phases, featuring hyperoxia-induced retinal vaso-obliteration in phase I, followed by retinal neovascularization in phase II. As neutrophils are acute responders to tissue damage, we evaluated whether neutrophil depletion with an anti-Ly6G mAb administered in phase I OIR influenced retinal inflammation and vascular injury. Neutrophils were measured in blood and spleen via flow cytometry, and myeloperoxidase, an indicator of neutrophil activity, was evaluated in the retina using Western blotting. Retinal vasculopathy was assessed by quantitating vaso-obliteration, neovascularization, vascular leakage, and VEGF levels. The inflammatory factors, TNF, MCP-1, and ICAM-1 were measured in retina. In the OIR controls, neutrophils were increased in the blood and spleen in phase I but not phase II OIR. In OIR, the anti-Ly6G mAb reduced neutrophils in the blood and spleen, and myeloperoxidase, inflammation, and vasculopathy in the retina. Our findings revealed that the early rise in neutrophils in OIR primes the retina for an inflammatory and angiogenic response that promotes severe damage to the retinal vasculature.
LSTM4piRNA: Efficient piRNA Detection in Large-Scale Genome Databases Using a Deep Learning-Based LSTM Network
Authors: Chen Chun-Chi , Chan Yi-Ming , Jeong Hyundoo
Published: October 2023

Piwi-interacting RNAs (piRNAs) are a new class of small, non-coding RNAs, crucial in the regulation of gene expression. Recent research has revealed links between piRNAs, viral defense mechanisms, and certain human cancers. Due to their clinical potential, there is a great interest in identifying piRNAs from large genome databases through efficient computational methods. However, piRNAs lack conserved structure and sequence homology across species, which makes piRNA detection challenging. Current detection algorithms heavily rely on manually crafted features, which may overlook or improperly use certain features. Furthermore, there is a lack of suitable computational tools for analyzing large-scale databases and accurately identifying piRNAs. To address these issues, we propose LSTM4piRNA, a highly efficient deep learning-based method for predicting piRNAs in large-scale genome databases. LSTM4piRNA utilizes a compact LSTM network that can effectively analyze RNA sequences from extensive datasets to detect piRNAs. It can automatically learn the dependencies among RNA sequences, and regularization is further integrated to reduce the generalization error. Comprehensive performance evaluations based on piRNAs from the piRBase database demonstrate that LSTM4piRNA outperforms current advanced methods and is well-suited for analysis with large-scale databases.
Minimally Invasive Cervical Styloidectomy in Stylohyoid Syndrome (Eagle Syndrome)
Authors: Bargiel Jakub , Gontarz Michał , Marecik Tomasz , Szczurowski Paweł , Gąsiorowski Krzysztof , Zapała Jan , Wyszyńska-Pawelec Grażyna
Published: October 2023

(1) Background: Stylohyoid syndrome, known as classical Eagle Syndrome (cES), is characterized by calcification of the stylohyoid chain with numerous nonspecific symptoms, mainly pain. This study introduces minimally invasive cervical styloidectomy (MICS). (2) Methods: MICS was performed on sixty-five patients diagnosed with classical Eagle Syndrome. Patients underwent meticulous differential diagnosis. Surgical plans were established based on the findings from neck angioCT. (3) Results: The healing process was uneventful, without significant complications. The overall success rate was 97.0%, with a follow-up of a minimum of six months. In one case, the surgery did not yield the desired improvement. In one case, a partial relapse of symptoms was observed. (4) Conclusions: MICS is a straightforward and efficient surgical treatment technique for stylohyoid syndrome.
Amplatzer™ Vascular Plugs for Embolisation: A 10-Year Single-Centre Retrospective Study
Authors: Loffroy Romaric , Chevallier Olivier , Mazit Amin , Malakhia Alexandre , Midulla Marco
Published: October 2023

Our objective was to investigate the indications, effectiveness, and safety of Amplatzer™ Vascular Plugs (AVPs) in clinical practice. To retrospectively identify patients managed with AVPs at the Dijon University Hospital between January 2011 and April 2021, we searched materials vigilance registries and procedure reports. The 110 identified patients underwent 111 procedures with delivery of 202 AVPs into 118 vessels; 84% of the procedures were performed by radiologists with over 10 years’ experience and 67% were scheduled. Varicocele, haemostasis, pelvic varicose veins, and arterio-venous dialysis fistulas accounted for 69% of procedures. The technical and clinical success rates were 99% and 97%, respectively. The single major complication was AVP migration in a high-flow internal iliac vein, with no residual abnormalities after successful device retrieval. Several AVPs and/or concomitant injection of coils or liquid agents were used in 80% of cases. The use of AVPs alone occurred chiefly for splenic artery embolisation in trauma patients and for collateral vein occlusion in dysfunctional arterio-venous dialysis fistulas. No cases of recanalisation occurred during the 19 ± 29 month follow-ups. Based on their good safety and effectiveness profile, AVPs deserve to be part of the therapeutic armamentarium of every interventional radiologist.
SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers
Authors: De Maria Luigi , Delvecchio Giuseppe , Sponselli Stefania , Cafaro Francesco , Caputi Antonio , Giannelli Gianmarco , Stefanizzi Pasquale , Bianchi Francesco Paolo , Stufano Angela , Tafuri Silvio , Lovreglio Piero , Boffetta Paolo , Vimercati Luigi
Published: October 2023

At the University Hospital of Bari, during the first year after the start of the mandatory vaccination campaign with BNT162b2 mRNA COVID-19 vaccine, the preliminary results of an observational study showed a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers (HCWs), but no hospitalization or deaths. In the present study, we extended the observation period (January 2021–January 2023) with the aim of determining the incidence, characteristics and clinical course of SARS-CoV-2 BIs among 6213 HCWs. All HCWs were regularly monitored and screened. To allow return to work after BI, the protocol required one negative nasopharyngeal swab test followed by a medical examination certifying complete clinical recovery. We observed an overall incidence rate of SARS-CoV-2 BIs of 20.2%. Females were most affected, especially in the nurse group compared with doctors and other HCWs (p < 0.0001). Cardiovascular diseases were the most frequent comorbidity (n = 140; 11.4%). The source of infection was non-occupational in 52.4% of cases. Most cases (96.9%) showed minor symptoms and only two cases of hospitalization (one in intensive care unit), 13 cases of re-infection and no deaths were recorded. Our results confirm that SARS-CoV-2 infection can break vaccination protection but the clinical course is favorable.
Reduction in Arterial Stiffness Index (SI) in Response to Combination Antioxidant Therapy
Authors: Howes Laurence Guy , Unni Tanya , Hamza Ameer , Howes Jan B. , Jayasinghe Rohan
Published: October 2023

Antioxidants reduce arterial stiffness, but the effects previously reported are weak. A systematic review of the antioxidants vitamin E, vitamin C, vitamin A, and beta-carotenes (the most commonly studied antioxidants) on pulse wave velocity (PWV) found an effect size of only −0.20 (approximately −16 m/s or −2.5%). Studies in rats of the potent pro-oxidant substance acetaldehyde have shown that combinations of sulfur-containing antioxidants, including thiamine and l-cysteine, with ascorbic acid potently protect against oxidative-stress-mediated mortality. The effects of these combinations of oxidants on PWV have not been studied. The present study evaluated the effects of 2 weeks of therapy with a combination of sulfur-containing antioxidants (cysteine, thiamine, and pyridoxine) in combination with ascorbic acid on stiffness index (SI), a measure of arterial stiffness that is strongly correlated with PWV, using a Pulse Trace recorder in a diverse group of 78 volunteers. SI fell by −1.7 m/s relative to placebo (95% confidence intervals −0.6 to −2.7 m/s), a reduction of −19% (95% confidence intervals −9% to −31%). The Glass effect size was 1.4, indicating a very strong treatment effect which was substantially greater than the effect size found in previous studies of antioxidants. PWV reduction was correlated significantly with increasing age. Further studies of similar antioxidant combinations are required to determine whether they are of value in the treatment or prevention of cardiovascular disease.
Building Complex Autologous Breast Reconstruction Program: A Preliminary Experience
Authors: Cho Min-Jeong , Slater Christopher A. , Skoracki Roman J. , Chao Albert H.
Published: October 2023

Autologous breast reconstruction is an increasingly popular method of reconstruction for breast cancer survivors. While deep inferior epigastric perforator (DIEP) flaps are the gold standard, not all patients are ideal candidates for DIEP flaps due to low BMI, body habitus, or previous abdominal surgery. In these patients, complex autologous breast reconstruction can be performed, but there is a limited number of programs around the world due to high technical demand. Given the increased demand and need for complex autologous flaps, it is critical to build programs to increase patient access and teach future microsurgeons. In this paper, we discuss the steps, pearls, and preliminary experience of building a complex autologous breast reconstruction program in a tertiary academic center. We performed a retrospective chart review of patients who underwent starting the year prior to the creation of our program. Since the start of our program, a total of 74 breast mounds have been reconstructed in 46 patients using 87 flaps. Over 23 months, there was a decrease in median surgical time for bilateral reconstruction by 124 min (p = 0.03), an increase in the number of co-surgeon cases by 66% (p < 0.01), and an increase in the number of complex autologous breast reconstruction by 42% (p < 0.01). Our study shows that a complex autologous breast reconstruction program can be successfully established using a multi-phase approach, including the development of a robust co-surgeon model. In addition, we found that a dedicated program leads to increased patient access, decreased operative time, and enhancement of trainee education.
Hepatic Impairment as a Risk Factor for Drug Safety: Suitability and Comparison of Four Liver Scores as Screening Tools
Authors: Golla Kathrin , Benesic Andreas , Mannell Hanna , Dreischulte Tobias , Grill Eva , Strobach Dorothea
Published: October 2023

Hepatic impairment (HI) influences the pharmacokinetics and pharmacodynamics of drugs and represents an important risk factor for drug safety. A reliable screening tool for HI identification at hospital admission by pharmacists would be desirable but is currently lacking. Therefore, we tested four liver scores as potential screening instruments. We retrospectively recorded liver/bile diagnoses, symptoms and abnormalities (summarized as hepatic findings) of 200 surgical patients followed by an assessment of the relevance of these findings for drug therapy (rating). The agreement between the Model of Endstage Liver Disease (MELD), Non-alcoholic fatty liver disease fibrosis score (NFS), Fibrosis 4 index (FIB-4), and aspartate-aminotransferase to platelet ratio index (APRI) and the rating was quantified by Cohen’s Kappa. The performance of the scores in this setting was further evaluated by their sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Of 200 patients, 18 (9%) had hepatic findings relevant for drug therapy. Fair agreement was found for FIB-4 and MELD and slight agreement for APRI and NFS compared to the rating. The highest values for sensitivity, specificity, PPV, and NPV were 41.2% (MELD), 99.3% (APRI), 66.7% (APRI), and 93.6% (MELD), respectively. Due to low performance, none of the scores can be recommended for clinical use as a single screening tool for HI at hospital admission.
Baccharis Species Essential Oils: Repellency and Toxicity against Yellow Fever Mosquitoes and Imported Fire Ants
Authors: Ali Abbas , Shah Farhan Mahmood , Manfron Jane , Monteiro Luciane M. , de Almeida Valter P. , Raman Vijayasankar , Khan Ikhlas A.
Published: October 2023

Essential oils from five Baccharis species were screened for their toxicity and biting deterrence/repellency against yellow fever mosquito, Aedes aegypti (L.), and imported fire ants, including Solenopsis invicta Buren (RIFA), Solenopsis richteri Forel (BIFA) and their hybrids (HIFA). Baccharis microdonta DC. and B. punctulata DC. at 10 µg/cm2 showed biting deterrence similar to DEET, N, N-diethyl-meta-toluamide at 25 nmol/cm2, whereas the repellency of B. pauciflosculosa DC., B. sphenophylla Dusén ex Malme and B. reticularioides Deble & A.S. Oliveira essential oils was significantly lower than DEET against mosquitoes. Two major compounds from the active essential oils, kongol and spathulenol, also exhibited biting deterrence similar to DEET against mosquitoes. The highest toxicity exhibited against mosquitoes was by Baccharis punctulata essential oil (LC50 = 20.4 ppm), followed by B. pauciflosculosa (LC50 = 31.9 ppm), B. sphenophylla (LC50 = 30.8 ppm), B. microdonta (LC50 = 28.6 ppm), kongol (LC50 = 32.3 ppm), spathulenol (LC50 = 48.7 ppm) and B. reticularioides essential oil (LC50 = 84.4 ppm). Baccharis microdonta essential oil showed repellency against RIFA, BIFA and HIFA at 4.9, 4.9 and 39 µg/g, respectively. Baccharis microdonta essential oil also showed toxicity with LC50 of 78.9, 97.5 and 136.5 µg/g against RIFA, BIFA and HIFA, respectively, at 24 h post treatment.
Point-of-Care Lung Ultrasound in the Intensive Care Unit—The Dark Side of Radiology: Where Do We Stand?
Authors: Di Serafino Marco , Dell’Aversano Orabona Giuseppina , Caruso Martina , Camillo Costanza , Viscardi Daniela , Iacobellis Francesca , Ronza Roberto , Sabatino Vittorio , Barbuto Luigi , Oliva Gaspare , Romano Luigia
Published: October 2023

Patients in intensive care units (ICUs) are critically ill and require constant monitoring of clinical conditions. Due to the severity of the underlying disease and the need to monitor devices, imaging plays a crucial role in critically ill patients’ care. Given the clinical complexity of these patients, who typically need respiratory assistance as well as continuous monitoring of vital functions and equipment, computed tomography (CT) can be regarded as the diagnostic gold standard, although it is not a bedside diagnostic technique. Despite its limitations, portable chest X-ray (CXR) is still today an essential diagnostic tool used in the ICU. Being a widely accessible imaging technique, which can be performed at the patient’s bedside and at a low healthcare cost, it provides additional diagnostic support to the patient’s clinical management. In recent years, the use of point-of-care lung ultrasound (LUS) in ICUs for procedure guidance, diagnosis, and screening has proliferated, and it is usually performed at the patient’s bedside. This review illustrates the role of point-of-care LUS in ICUs from a purely radiological point of view as an advanced method in ICU CXR reports to improve the interpretation and monitoring of lung CXR findings.
History in Points, Lines and Polygons: Time Depth in the Landscape of Guangdong Province, Southern China
Authors: Pan Ying , Bai Jiayu , Turner Sam
Published: October 2023

Change and persistence are often richly entangled facets of landscapes. While many studies use land use/land cover (depicted as polygons) to illustrate landscape evolution, this paper draws on approaches from landscape archaeology to investigate how lines and points can also be used to examine landscape morphologies. The study uses three distinct spatial elements: points (graves), lines (field boundaries), and polygons (land use) to represent landscape transformations and reflect time depth in the landscape. The paper aims to identify the most enduring landscape elements within the region and uncover the underlying mechanisms of persistence. It is suggested that the time depth exhibited in field boundaries surpasses that of land use in this case. Field boundaries provide a useful way to examine agricultural intensification, whereas land use is more sensitive to agricultural commercialization and urbanization. In addition, the Chinese Feng Shui funeral culture emerges as a stabilizing force that encourages landscape persistence. This cultural driver ensures the persistence of field patterns surrounding graves, making these fields the most ancient plots within the study area. In conclusion, representing the time depth of landscapes through linear features and points can serve as an important supplement to the study of landscape change based on land use.
Recognition of Wheat Leaf Diseases Using Lightweight Convolutional Neural Networks against Complex Backgrounds
Authors: Wen Xiaojie , Zeng Minghao , Chen Jing , Maimaiti Muzaipaer , Liu Qi
Published: October 2023

Wheat leaf diseases are considered to be the foremost threat to wheat yield. In the realm of crop disease detection, convolutional neural networks (CNNs) have emerged as important tools. The training strategy and the initial learning rate are key factors that impact the performance and training speed of the model in CNNs. This study employed six training strategies, including Adam, SGD, Adam + StepLR, SGD + StepLR, Warm-up + Cosine annealing + SGD, Warm-up + Cosine, and annealing + Adam, with three initial learning rates (0.05, 0.01, and 0.001). Using the wheat stripe rust, wheat powdery mildew, and healthy wheat datasets, five lightweight CNN models, namely MobileNetV3, ShuffleNetV2, GhostNet, MnasNet, and EfficientNetV2, were evaluated. The results showed that upon combining the SGD + StepLR with the initial learning rate of 0.001, the MnasNet obtained the highest recognition accuracy of 98.65%. The accuracy increased by 1.1% as compared to that obtained with the training strategy with a fixed learning rate, and the size of the parameters was only 19.09 M. The above results indicated that the MnasNet was appropriate for porting to the mobile terminal and efficient for automatically identifying wheat leaf diseases.
Analysis of Kinematic and Muscular Fatigue in Long-Distance Swimmers
Authors: Puce Luca , Biz Carlo , Ruaro Alvise , Mori Fabiana , Bellofiore Andrea , Nicoletti Pietro , Bragazzi Nicola Luigi , Ruggieri Pietro
Published: October 2023

Muscle fatigue is a complex phenomenon that is influenced by the type of activity performed and often manifests as a decline in motor performance (mechanical failure). The purpose of our study was to investigate the compensatory strategies used to mitigate mechanical failure. A cohort of 21 swimmers underwent a front-crawl swimming task, which required the consistent maintenance of a constant speed for the maximum duration. The evaluation included three phases: non-fatigue, pre-mechanical failure, and mechanical failure. We quantified key kinematic metrics, including velocity, distance travelled, stroke frequency, stroke length, and stroke index. In addition, electromyographic (EMG) metrics, including the Root-Mean-Square amplitude and Mean Frequency of the EMG power spectrum, were obtained for 12 muscles to examine the electrical manifestations of muscle fatigue. Between the first and second phases, the athletes covered a distance of 919.38 ± 147.29 m at an average speed of 1.57 ± 0.08 m/s with an average muscle fatigue level of 12%. Almost all evaluated muscles showed a significant increase (p < 0.001) in their EMG activity, except for the latissimus dorsi, which showed a 17% reduction (ES 0.906, p < 0.001) during the push phase of the stroke cycle. Kinematic parameters showed a 6% decrease in stroke length (ES 0.948, p < 0.001), which was counteracted by a 7% increase in stroke frequency (ES −0.931, p < 0.001). Notably, the stroke index also decreased by 6% (ES 0.965, p < 0.001). In the third phase, characterised by the loss of the ability to maintain the predetermined rhythm, both EMG and kinematic parameters showed reductions compared to the previous two phases. Swimmers employed common compensatory strategies for coping with fatigue; however, the ability to maintain a predetermined motor output proved to be limited at certain levels of fatigue and loss of swimming efficiency (Protocol ID: NCT06069440).
Arsenic Removal and Iron Recovery from Arsenic-Bearing Iron Ores by Calcification-Magnetic Roasting and Magnetic Separation Process
Authors: Dai Mengbo , Zhou Yongcheng , Xiao Qingfei , Lv Jinfang , Huang Lingyun , Xie Xian , Hu Yiming , Tong Xiong , Chun Tiejun
Published: October 2023

Extracting iron while minimizing the health and environmental risks associated with arsenic contamination necessitates the removal of arsenic from arsenic-bearing iron ores to ensure a safe and sustainable supply of this metal for industries. The beneficiation of iron minerals and arsenic-bearing minerals from arsenic-bearing iron ores with a calcification-magnetizing roasting and low-intensity magnetic separation (CMR-LMS) process is investigated in this work. The results show that the process is successful in extracting iron minerals and eliminating arsenic-containing minerals. The roasting involves two key steps: calcification and magnetizing, which change hematite and goethite into magnetite and arsenic-bearing minerals into calcium arsenates. The process’s separation efficiency of the CMR-LMS is closely linked to the parameters such as roasting temperature, roasting time, coke, alkalinity, and the liberation of gangue minerals from iron minerals. Through grinding and secondary magnetic separation, the iron minerals and gangue components, as well as arsenic, in roasted sand can be further separated. The optimum procedure results in a high-grade iron concentrate with an iron assay of 65.65%, an Fe recovery rate of 80.07%, and an arsenic content of 0.085%, while achieving a 93.29% As removal rate from the original ore that has 45.32% Fe and 0.70% As.
Guidelines for Natural Stone Products in Connection with European Standards
Authors: Strzałkowski Paweł , Köken Ekin , Sousa Luís
Published: October 2023

The selection of ornamental stones for specific applications requires technical guidance since it should be based on the durability, service life, and aesthetic value of the stones. In most cases, these fundamentals provide quantitative data on the usability and performance of ornamental stones. The present study attempts to put forward a quantitative classification system for natural stone products concerning critical rock properties. For this purpose, fundamental physical and mechanical rock properties are listed based on European standards. Then, minimum limit values are proposed for different applications of natural stone products based on retrospective analyses of numerous ornamental stone applications. The suggested limit values based on several physical and mechanical rock properties can guide relevant engineers to initially consider possible rock types for use as natural stones in a wide range of applications. In this context, it is believed that the present study contributes to the natural stone industry by discussing the minimum limit values for the consideration of a wide range of rock types possibly usable in the dimension stone industry.
High-Temperature Chlorination of Nickel Oxide Using Calcium Chloride
Authors: Han Peiwei , Yan Jingmin , Zhang Lunliang , Li Zhengchen , Ye Shufeng
Published: October 2023

Attempts have been made to extract nickel from ores and nickel-containing wastes using the chlorination method. However, the use of gaseous chlorinating agents is limited due to their toxicity. High-temperature chlorination of nickel oxide using calcium chloride is analyzed in this study. The volatilization percentage is positively correlated to temperature and CaCl2 dosage and negatively correlated to oxygen partial pressure. The apparent activation energy is calculated to be 142.91 kJ/mol, between 1173 K and 1323 K, which suggests that the high-temperature chlorination of nickel oxide using calcium chloride is controlled by a chemical reaction.
Fabrication of Europium-Doped CaF2 Films via Sol-Gel Synthesis as Down-Shifting Layers for Solar Cell Applications
Authors: Pellegrino Anna Lucia , Milan Emil , Speghini Adolfo , Malandrino Graziella
Published: October 2023

In the present work, an in-depth study on the sol-gel process for the fabrication of Eu-doped CaF2 materials in the form of thin films has been addressed for the production of down-shifting layers. Fine-tuning of the operative parameters, such as the annealing temperature, substrate nature and doping ion percentage, has been finalized in order to obtain Eu(III)-doped CaF2 thin films via a reproducible and selective solution process for down-shifting applications. An accurate balance of such parameters allows for obtaining films with high uniformity in terms of both their structural and compositional features. The starting point of the synthesis is the use of a mixture of Ca(hfa)2•diglyme•H2O and Eu(hfa)3•diglyme adducts, with a suited ratio to produce 5%, 10% and 15% Eu-doped CaF2 films, in a water/ethanol solution. A full investigation of the structural, morphological and compositional features of the films, inspected using X-ray diffraction analysis (XRD), field emission scanning electron microscopy (FE-SEM) and energy dispersive X-ray analysis (EDX), respectively, has stated a correlation between the annealing temperature and the structural characteristics and morphology of the CaF2 thin films. Interestingly, crystalline CaF2 films are obtained at quite low temperatures of 350–400 °C. The down-shifting properties, validated by taking luminescence measurements under UV excitation, have allowed us to correlate the local environment in terms of the degree of symmetry around the europium ions with the relative doping ion percentages.
Screening Ba0.9A0.1MnO3 and Ba0.9A0.1Mn0.7Cu0.3O3 (A = Mg, Ca, Sr, Ce, La) Sol-Gel Synthesised Perovskites as GPF Catalysts
Authors: Ghezali Nawel , Díaz Verde Álvaro , Illán Gómez María José
Published: October 2023

Ba0.9A0.1MnO3 (BM-A) and Ba0.9A0.1Mn0.7Cu0.3O3 (BMC-A) (A = Mg, Ca, Sr, Ce, La) perovskite-type mixed oxides were synthesised, characterised, and used for soot oxidation in simulated Gasoline Direct Injection (GDI) engine exhaust conditions. The samples have been obtained by the sol-gel method in an aqueous medium and deeply characterised. The characterization results indicate that the partial substitution of Ba by A metal in BaMnO3 (BM) and BaMn0.7Cu0.3O3 (BMC) perovskites: (i) favours the hexagonal structure of perovskite; (ii) improves the reducibility and the oxygen desorption during Temperature-Programmed Desorption (O2-TPD) tests and, consequently, the oxygen mobility; (iii) mantains the amount of oxygen vacancies and of Mn(IV) and Mn(III) oxidation states, being Mn(IV) the main one; and (iv) for Ba0.9A0.1Mn0.7Cu0.3O3 (BMC-A) series, copper is partially incorporated into the structure. The soot conversion data reveal that Ba0.9La0.1Mn0.7Cu0.3O3 (BMC-La) is the most active catalyst in an inert (100% He) reaction atmosphere, as it presents the highest amount of copper on the surface, and that Ba0.9Ce0.1MnO3 (BM-Ce) is the best one if a low amount of O2 (1% O2 in He) is present, as it combines the highest emission of oxygen with the good redox properties of Ce(IV)/Ce(III) and Mn(IV)/Mn(III) pairs.
Material Extrusion to Manufacture Carbide-Based Advanced Cutting Tools
Authors: Oliveira Gonçalo , Senos Ana , Fernandes Cristina , Figueiredo Daniel , Vieira Teresa
Published: October 2023

Material extrusion (MEX) allows for the production of advanced cutting tools with new internal cooling systems, which are suitable for new machining equipment. To produce cutting tools via this process, hardmetal and cermet feedstock must be prepared for the extrusion of 3D printing filaments. After shaping the 3D object (green), debinding and sintering must be performed to achieve densification. Defects and microstructural heterogeneities were studied according to the powder material. The present study shows that, although MEX is a viable solution for hardmetals, it needs to produce homogeneous filaments for cermets. The WC-Co bulk microstructures versus hardness were similar to the ones that were measured with pressing and sintering. While cermet (Ti(CN)/WC-Ni/Co) microstructures were heterogeneous, their hardness, when compared with that from the pressing and sintering manufacturing process, decreased significantly.
The Evolution of a Microstructure during Tempering and Its Influence on the Mechanical Properties of AerMet 100 Steel
Authors: Wang Hongli , Zhang Jian , Huang Jingtao , Wu Chengchuan , Zhang Xianguang , Lai Zhonghong , Liu Yong , Zhu Jingchuan
Published: October 2023

In order to provide guidance for furthering the balance of strength and toughness of AerMet 100 steel through tempering treatment, the effects of the tempering time on microstructure and mechanical properties are investigated. The microstructure evolution, especially M2C precipitates and austenite in AerMet 100 tempered at 482 °C for 1~20 h, was characterized, and its influences on the mechanical properties were studied. The tensile strength decreases gradually, the yield strength increases first and then decreases, and the fracture toughness KIC increases gradually with an increasing tempering time. The strength and toughness matching of AerMet 100 steel is achieved by tempering at 482 °C for 5~7 h. Without considering the martensitic size effect, the influence of the dislocation density on the tensile strength is more significant during tempering at 482 °C. The precipitation strengthening mechanism plays a dominant role in the yield strength when tempering for 5 h or less, and the combined influence of carbide coarsening and a sharp decrease in the dislocation density resulted in a significant decrease in tensile strength when tempering for 8 h or more. The fracture toughness KIC is primarily influenced by the reverted austenite, so that KIC increases gradually with the prolongation of the tempering time. However, a significant decrease in the dislocation density resulting from long-term tempering has a certain impact on KIC, giving rise to a decrease in the rising amplitude in KIC after tempering for 8 h or more.
Reliability Analysis of PAUT Based on the Round-Robin Test for Pipe Welds with Thermal Fatigue Cracks
Authors: Kang Dongchan , Choi Yu Min , Lee Dong Min , Kim Jung Bin , Kim Yong Kwon , Park Tae Sung , Park Ik Keun
Published: October 2023

Thermal fatigue cracks occurring in pipes in nuclear power plants pose a high degree of risk. Thermal fatigue cracks are generated when the thermal fatigue load caused by local temperature gradients is repeatedly applied. The flaws are mainly found in welds, owing to the effects of stress concentration caused by the material properties and geometric shapes of welds. Thermal fatigue pipes are classified as targets of risk-informed in-service inspection, for which ultrasonic testing, a volumetric non-destructive testing method, is applied. With the advancement of ultrasonic testing techniques, various studies have been conducted recently to apply the phased array ultrasonic testing (PAUT) method to the inspection of thermal fatigue cracks occurring on pipes. A quantitative reliability analysis of the PAUT method must be performed to apply the PAUT method to on-site thermal fatigue crack inspection. In this study, to evaluate the quantitative reliability of the PAUT method for thermal fatigue cracks, we fabricated crack specimens with the thermal fatigue mechanism applied to the pipe welds. We performed a round-robin test to collect PAUT data and determine the validity of the detection performance (probability of detection; POD) and the error in the sizing accuracy (root-mean-square error; RMSE) evaluation. The analysis results of the POD and sizing performance of the length and depth of thermal fatigue cracks were comparatively evaluated with the acceptance criteria of the American Society of Mechanical Engineers Code to confirm the effectiveness of applying the PAUT method.
Description and Characterization of the Odontella aurita OAOSH22, a Marine Diatom Rich in Eicosapentaenoic Acid and Fucoxanthin, Isolated from Osan Harbor, Korea
Authors: An Sung Min , Cho Kichul , Kim Eun Song , Ki Hyunji , Choi Grace , Kang Nam Seon
Published: October 2023

Third-generation biomass production utilizing microalgae exhibits sustainable and environmentally friendly attributes, along with significant potential as a source of physiologically active compounds. However, the process of screening and localizing strains that are capable of producing high-value-added substances necessitates a significant amount of effort. In the present study, we have successfully isolated the indigenous marine diatom Odontella aurita OAOSH22 from the east coast of Korea. Afterwards, comprehensive analysis was conducted on its morphological, molecular, and biochemical characteristics. In addition, a series of experiments was conducted to analyze the effects of various environmental factors that should be considered during cultivation, such as water temperature, salinity, irradiance, and nutrients (particularly nitrate, silicate, phosphate, and iron). The morphological characteristics of the isolate were observed using optical and electron microscopes, and it exhibited features typical of O. aurita. Additionally, the molecular phylogenetic inference derived from the sequence of the small-subunit 18S rDNA confirmed the classification of the microalgal strain as O. aurita. This isolate has been confirmed to contain 7.1 mg g−1 dry cell weight (DCW) of fucoxanthin, a powerful antioxidant substance. In addition, this isolate contains 11.1 mg g−1 DCW of eicosapentaenoic acid (EPA), which is one of the nutritionally essential polyunsaturated fatty acids. Therefore, this indigenous isolate exhibits significant potential as a valuable source of bioactive substances for various bio-industrial applications.
Effectiveness of Intravenous Non-Opioid Analgesics for Postoperative Pain Management of in Patients Undergoing Hip Surgery: A Systematic Review and Meta-Analysis
Authors: Chang Jae Suk , Lee Dong Hwan , Kang Min Wook , Kim Ji Wan , Kim Chul-Ho
Published: October 2023

Background and Objectives: Intravenous (IV) non-opioid analgesics (NOAs) have been extensively investigated as a multimodal analgesic strategy for the management of acute pain after hip surgery. This pair-wise meta-analysis examined IV NOA effects following hip surgery. Materials and Methods: A systematic search of the MEDLINE (PUBMED), Embase, and Cochrane Library databases was performed for studies investigating the effect of IV NOA for postoperative pain management following hip surgery up to 7 June 2023. We compared in-admission opioid use, postoperative VAS (visual analogue scale) score, hospital stay duration, and opioid-related adverse events between IV NOA and control groups. Results: Seven studies were included with a total of 953 patients who underwent hip surgery. Of these, 478 underwent IV NOA treatment, and 475 did not. The IV NOA groups had lower opioid use within 24-h following hip surgery (SMD, −0.48; 95% CI, −0.66 to −0.30; p < 0.01), lower VAS score (SMD, −0.47; 95% CI, −0.79 to −0.16; p < 0.01), shorter hospital stay (SMD, −0.28; 95% CI, −0.44 to −0.12; p < 0.01), and lower incidence of nausea and vomiting (OR, 0.32; 95% CI, 0.15 to 0.67; p < 0.01) compared with the control groups. Conclusions: This meta-analysis demonstrated that IV NOA administration following hip surgery may have more favorable postoperative outcomes than those in control groups.
Deep Learning-Based Understanding of Defects in Continuous Casting Product
Authors: Ding Zeyuan , Zhao Jingxiao , Misra Raja Devesh Kuma , Guo Fujian , Xie Zhenjia , Wang Xuelin , Li Xiucheng , Wang Jingliang , Shang Chengjia
Published: October 2023

A novel YOLOv5 network is presented in this paper to quantify the degree of defects in continuously cast billets. The proposed network addresses the challenges posed by noise or dirty spots and different defect sizes in the images of these billets. The CBAM-YOLOv5 network integrates the channel and spatial attention of the Convolutional Block Attention Module (CBAM) with the C3 layer of the YOLOv5 network structure to better fuse channel and spatial information, with focus on the defect target, and improve the network’s detection capability, particularly for different levels of segregation. As a result, the feature pyramid is improved. The feature map obtained after the fourth down-sampling of the backbone network is fed into the feature pyramid through CBAM to improve the perceptual field of the target and reduce information loss during the fusion process. Finally, a self-built dataset of continuously cast billets collected from different sources is used, and several experiments are conducted using this database. The experimental results show that the average accuracy (mAP) of the network is 93.7%, which can achieve intelligent rating.
Corrosion Behaviour Modelling Using Artificial Neural Networks: A Case Study in Biogas Environment
Authors: Jiménez-Come María Jesús , González Gallero Francisco Javier , Álvarez Gómez Pascual , Mena Baladés Jesús Daniel
Published: October 2023

The main objective established in this work was to develop a model based on artificial neural networks (ANNs) to predict the corrosion status of stainless steel involved in biogas production, analyzing the influence of the material composition and the breakdown potential value. To achieve this objective, an ANN model capable of predicting the corrosion status of the material without the need to perform microscopic analysis on the material surface was proposed. The applicability of the corrosion models was verified via the experimental data considering different factors such as stainless steel composition, biogas environments simulated by artificial solution, temperature, surface finish, and the breakdown potential of the passive layer of stainless steel obtained from electrochemical tests. The optimal prediction performance shown by the model in terms of specificity and sensitivity values were 0.969 and 0.971, respectively, obtaining an accuracy of 0.966. Furthermore, analyzing the influence of the breakdown potential on corrosion modelling, an alternative model was presented capable of predicting the corrosion status automatically, without the need to resort to electrochemical tests for new conditions. The results demonstrated the utility of this technique to be considered in design and maintenance planning tasks for stainless steel structures subjected to localized corrosion in biogas production.
Enhancing the Sensitivity of Lateral Flow Assay with Europium Nanoparticles for Accurate Human IgG Quantification
Authors: Natarajan Satheesh , Priye Aashish
Published: October 2023

Accurate quantification of immunoglobulin G (IgG) levels is vital for understanding immune status and diagnosing various medical conditions. Lateral flow assays (LFAs) offer rapid and convenient diagnostic tools, but their sensitivity has been a limitation. Our research introduces a refined method incorporating europium nanoparticles, enhancing both sensitivity and accuracy of LFAs in human IgG measurement. Utilizing a unique sandwich format, carboxylate-modified polystyrene Eu (III) chelate microparticles (CM-EUs) acted as the primary reporters. The concentrations of both detection and capture antibodies on the strip were optimized to bolster the LFA’s quantitative performance. The subsequent calibration curve between the IgG concentration and the measured intensity ratio (VR) established the linearity and analytical sensitivity of our method with a high correlation coefficient (r = 0.99) and an impressively low limit of detection (LoD = 0.04 ng/mL). Our precision assessment, segmented into intra-assay and inter-assay evaluations, showcases the method’s consistency and reproducibility. The LFA assay’s stability was established by demonstrating its resistance to degradation and affirming its potential for extended storage without a dip in performance. The study’s findings underscore the potential of this method to contribute to diagnostic medicine and improve patient care.
Research on an Enhanced Detuned-Loading Effect in Integrated Two-Section DFB Lasers with High Modulation Bandwidths
Authors: Zhang Yunshan , Gu Hongming , Ma Guolong , Guan Shijian , Fang Tao , Chen Xiangfei
Published: October 2023

A novel high-speed directly modulated two-section distributed-feedback (TS-DFB) semiconductor laser based on the detuned-loading effect is proposed and simulated. A grating structure is designed by the reconstruction-equivalent-chirp (REC) technique. A π phase shift is introduced into the reflection grating, which can provide a narrow-band reflection region with a sharp falling slope on both sides of the reflection spectrum, thus enhancing the detuned-loading effect. Owing to its unique dual-falling-edges structure, the bandwidth can be improved even when the lasing wavelength shifts beyond the left falling edge due to a thermal effect in the actual test, in which condition the detuned-loading effect can be used twice, which greatly improves the yield. The modulation bandwidth is increased from 17.5 GHz for a single DFB laser to around 24 GHz when the lasing wavelength is located on the left falling edge of the TS-DFB laser based on the detuned-loading effect, and it can be increased to 22 GHz for the right side. An eight-channel laser array with precise wavelength spacing is investigated, with a side-mode suppression ratio (SMSR) >36 dB. In addition, TS-DFB lasers with uniform reflection gratings are studied, and simulated results show that the modulation characteristic is far inferior to the laser with a phase-shifted grating reflector.
Construction of MoS2-ReS2 Hybrid on Ti3C2Tx MXene for Enhanced Microwave Absorption
Authors: Xu Xiaoxuan , Xing Youqiang , Liu Lei
Published: October 2023

Utilizing interface engineering to construct abundant heterogeneous interfaces is an important means to improve the absorbing performance of microwave absorbers. Here, we have prepared the MXene/MoS2-ReS2 (MMR) composite with rich heterogeneous interfaces composed of two-dimensional Ti3C2Tx MXene and two-dimensional transition metal disulfides through a facile hydrothermal process. The surface of MXene is completely covered by nanosheets of MoS2 and ReS2, forming a hybrid structure. MRR exhibits excellent absorption performance, with its strongest reflection loss reaching −51.15 dB at 2.0 mm when the filling ratio is only 10 wt%. Meanwhile, the effective absorption bandwidth covers the range of 5.5–18 GHz. Compared to MXene/MoS2 composites, MRR with a MoS2-ReS2 heterogeneous interface exhibits stronger polarization loss ability and superior absorption efficiency at the same thickness. This study provides a reference for the design of transition metal disulfides-based absorbing materials.
Optimizing Thermoelectric Performance of Tellurium via Doping with Antimony and Selenium
Authors: Yang Manman , Yang Mengxiang , Li Yimin , Chen Yuqi , Song Yuling , Jia Jin , Su Taichao
Published: October 2023

Forming solid solutions is one of the most effective strategies to suppress the thermal conductivity of thermoelectric materials. However, the accompanying increase in impurity ion scattering usually results in an undesirable loss in hall mobility, negatively impacting the electrical transport properties. In this work, a tellurium–selenium (Te-Se) solid solution with trace antimony (Sb) doping was synthesized via the high pressure and high temperature method. It was found that slight Se doping into the Te sites not only had no impact on the hall mobility and carrier concentration, but also enhanced the density-of-state effective mass of Sb0.003Te0.997, leading to an enhanced power factor near room temperature. Additionally, the presence of Se doping caused a significant reduction in the phonon thermal conductivity of Te due to fluctuations in the mass and strain field. The lowest phonon thermal conductivity was as low as ~0.42 Wm−1K−1 at 600 K for Sb0.003Se0.025Te0.972, which approached the theoretical minimum value of Te (~0.28 Wm−1K−1). The effects of Se doping suppressed thermal conductivity, while Sb doping enhanced the power factor, resulting in a larger ZT of ~0.94 at 600 K. Moreover, these findings demonstrate that Sb and Se doping can effectively modulate the electrical and thermal transport properties of Te in a synergistic manner, leading to a significant increase in the average ZT across a wide temperature range.