bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery, Isolation, Heterologous Expression and Mode-of Action Studies of the Antibiotic Polyketide Tatiomicin from Amycolatopsis sp. DEM30355
Authors: Kepplinger Bernhard , Mardiana Lina , Cowell Joseph , Morton-Laing Stephanie , Dashti Yousef , Wills Corinne , Marrs Emma , Perry John , Gray Joe , Goodfellow Michael , Errington Jeff , Probert Michael , Clegg William , Bogaerts Jonathan , Herrebout Wouter , Allenby Nick , Hall Michael
Published: April 2022

A genomic and bioactivity informed analysis of the metabolome of the extremophile Amycolatopsis sp. DEM30355 has allowed for the discovery and isolation of the polyketide antibiotic tatiomicin. Identification of the biosynthetic gene cluster was confirmed by heterologous expression in Streptomyces coelicolor M1152. Structural elucidation, including absolute stereochemical assignment, was performed using complementary crystallographic, spectroscopic and computational methods. Tatiomicin shows antibiotic activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Cytological profiling experiments suggest a putative antibiotic mode-of-action, involving membrane depolarisation and chromosomal decondensation of the target bacteria.
Gorham-Stout syndrome: a chylothorax disease with massive bony destruction
Authors: Hong Ping-Yang , Zhang Xiao-Bin , Zhao Yi-Lin , Huang Mao-Hong , Zeng Hui-Qing
Published: April 2022

Gorham–Stout syndrome is a sporadic condition characterized by a tumor-like lesion with extensive osteolysis, severe symptoms, and a poor prognosis. Poor prognostic indicators include osteolytic lesions of the spine and pleura effusion. We presented a case in which the condition first manifested itself at the age of 67, with exacerbated shortness of breath. The patient's imaging studies (CT scan, MRI, and PET/CT) revealed osteolytic lesions (the skull, several spines, several ribs, both shoulder blades, and the pelvis). After a tissue biopsy of the spine, postoperative pathology revealed that a portion of the bone had been replaced by lymphatic-derived endothelial cells that stained positive for D2-40. The tests permitted parasitosis, thyroid or parathyroid disease, parasitosis, lymphoma, neoplasia, or an autoimmune problem to be ruled out. On the patient, we performed a superior vena cava angiography. There was an abnormal expansion of the azygos vein into the superior vena cava, as well as local contrast agent retention. The injection of zoledronic acid was used to prevent bone loss. After the therapy, his shortness of breath was greatly reduced. He experienced ongoing shortness of breath alleviation during the 2-month follow-up visit.
Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers
Authors: Zurac Sabina , Vladan Cristian , Dinca Octavian , constantin Carolina , Neagu Monica
Published: April 2022

Waning of the immune response upon vaccination in SARS-CoV-2 infection is an important subject of evaluation in this pandemic, mostly in healthcare workers (HCW) that are constantly in contact with infected samples and patients. Therefore, our study aimed to establish the specific humoral response of specific IgG and IgA antibodies upon vaccination, during the second year of pandemic and evaluating the booster shot with the same vaccine type. A group of 103 HCW with documented exposure to the virus were monitored for specific IgG and IgA levels prior to vaccination, after the first vaccination round, during the following 8 months and after the booster shot with the same vaccine type. After 8 months post-vaccination the humoral response in both IgG and IgA decreased, 2.4 times for IgG, and 2.7 times for IgA. Although the antibodies levels significantly decreased, no documented infection was registered in the group. After the booster shot, the entire group, displayed IgG increased levels, immediately after booster followed by the increase in specific IgA. IgG levels post-second round of vaccination are statistically higher compared to the first round, while IgA is restored at the same levels. Within the vaccination or booster routine for a multiple waves’ pandemic that is generating new virus variants, populational immunity remains an important issue for future implementation of prevention/ control measures.
Intelligent 4G Cellular Network Fault Prediction Model
Authors: N Geethu , M. Rajesh
Published: April 2022

From 1G to 5G and beyond cellular network technologies evolve in terms of technical advancement, efficiency, and traffic. Increase in accessibility and data utilization are the notable factors that are causing high network traffic. Higher the connectivity and mobility of cellular devices, higher will be the network traffic. As the transmission rate increases, the possibility of fault occurrence also increases. Continuous monitoring of network parameters and finding the fault on time are the key factors in determining consistency of network. Cellular network which is highly dynamic than usual networks needs intelligent way of fault handling. The monitoring and fault identification human overhead are unpredictable and very high and can cause errors as well. The research in modelling intelligent network fault identification system can simplify human efforts and improve efficiency. The research is on real time data of 4G cellular network including various network parameters like uplink threshold and identify the behaviour of data usual or unusual to predict the fault occurrence. The numerical dataset on various network parameters on usual and unusual behaviours helps to simplify the feature extraction part and to reduce the complexity of the model. The model is finalized based on various machine learning-deep learning model analysis.
A Rapid Tigecycline and Polymyxin B Susceptibility Test for Klebsiella pneumoniae Using Direct-on-Target Micro-droplet Growth Assay
Authors: Xia Zhaoxin , Yang Wensu , Zhu Yi , Xu Huaming , Tang Hao , Lu Guoping , Liu Zhen , Hu Xinyi , Lin Chunhui , Jiang Tong , Shen Jilu
Published: April 2022

Background
Tigecycline (TGC) and polymyxin B (PMB)are important antibiotics for the treatment of multidrug-resistant bacterial infections. However, with the widespread applications, the resistant strains have been isolated. To optimize the use of TGC and PMB, there is an urgent need to develop a rapid detection method for the antibiotics. In recent years, a novel Direct-on-Target Micro-droplet Growth Assay (DOT-MGA) has been developed that can detect antibiotic resistance within hours. The study aims to verify the feasibility and accuracy of DOT-MGA in rapidly identification of TGC and PMB-susceptible and non-susceptible bacteria.
Methods
A total of 67 strains of Klebsiella pneumoniae were collected for DOT-MGA. According to FDA/EUCAST breakpoint concentrations, 6 µL droplets with or without TGC or PMB were added in triplicate into the wells of the MALDI plate with four incubation time points (3 h, 4 h, 6 h, and 8 h). The results were compared with standard databases using Bruker Biotyper software and classified as susceptible and non-susceptible based on the scores.
Results
Compared with the micro-broth dilution method, the DOT-MGA achieved the best detection performance after 4 h of incubation. The results showed that the growth efficiency of TGC and PMB were both 100%, and the classification agreement rates were 98.15% and 96.15%, respectively.
Conclusion
With the 4h incubation time, DOT-MGA can accurately identify the resistance of TGC and PMB, which has good consistency compared with the micro-dilution method. DOT-MGA can provide rapid and reliable drug susceptibility diagnosis, which is of great significance for the clinical anti-infective treatment.
Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells
Authors: Chan Kok Meng , Razali Nur Syahirah Che , Lam Kok Wai , Rajab Nor Fadilah , Jamal A Rahman A , Kamaluddin Nurul Farahana
Published: April 2022

Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to overcome these limitations. In this study, the analogues were assessed on human glioblastoma LN-18 cells in comparison to curcumin. Results from cytotoxicity assessment showed that FLDP-5 and FLDP-8 curcuminoid analogues caused death in LN-18 cells in a concentration-dependent manner after 24-h treatment with much lower IC50 values of 2.5 µM and 4 µM respectively, which were more potent compared to curcumin with IC50 of 31 µM. Moreover, a significant increase (p<0.05) in the level of superoxide anion and hydrogen peroxide upon 2-h and 6-h treatment confirmed the oxidative stress involvement in the cell death process induced by these analogues. These analogues also showed potent anti-migratory effects through inhibition of LN-18 cells’ migration and invasion. In addition, cell cycle analysis showed that these analogues are capable of inducing S-phase cell cycle arrest during the 24-hour treatment, which explained the reduced proliferation indicated by MTT assay. In conclusion, these curcuminoid analogues exhibit potent anti-cancer effects with anti-proliferative and anti-migratory properties towards LN-18 cells as compared to curcumin.
Green Intellectual Capital and Green Supply Chain Performance: Does Big Data Analytics Capabilities matter?
Authors: AL-Khatib Ayman , Shuhaiber Ahmed
Published: April 2022

The current study aimed to identify the impact of the components of green intellectual capital (green human capital, green structural capital and green relational capital) on green supply chain performance in the manufacturing sector in Jordan as well as the moderating role of big data analytics capabilities. Structural equation modelling was used through the Smart-PLS program on a sample of 438 participants. The results showed that each component of the green intellectual capital and big data analytics explains 71.1% of the variance in green supply chain performance and that all components of green intellectual capital have a statistically significant impact on green supply chain performance. The results also revealed that the relationship between green relational capital and green supply chain performance is moderated through big data analytics capabilities. In general, this study made a theoretical and managerial contribution to the supply chain literature.
The presence of EcPV-2 DNA in aborted samples is evidence for vertical transmission of EcPV
Authors: Xie Jinxin , Tong Panpan , Tian Shuyao , Song Xiaozhen , Yang Enhui , Ma Wanpeng , Kuang Ling , Wang Jinquan
Published: April 2022

Nine different species of Equus caballus papillomavirus (EcPV) and three bovine papillomaviruses (BPV) have been reported to infect horses, however, there are so far no describing such infections in China. In our pioneer study with Chinese horses, we first found EcPV-2 in the nasal swabs (4/230, 1.7%) of Yili horses, and semen (3/18, 16.7%) of the Thoroughbred horses. This indicated that EcPV can be indeed hosted by horses in China, and that EcPV-2 might be transmitted though breeding. Further detection of EcPVs and BPVs in the aborted fetal lung tissues of Yili mares, which were originally negative for equid herpesviruses, demonstrated that EcPV-2 was positive in 19 out of 50 samples, thereby indicating this finding is first evidence for vertical transmission of EcPV, simultaneous suggesting that EcPV-2 might be a new pathogen causing of responsible for abortions. Thereafter, the sequence analyses for L1 genes sequences of 26 China’s EcPV-2 were performed which indicated that EcPV-2, that primarily infected the horses in China, shared 98.3%-99.9% nt identity with the already published sequences for EcPV-2. These observations indicated that EcPV-2 identified in the current study were highly similar variants of the previously identified strains of EcPV-2. Phylogenetic analysis based on L1 genes in GenBank showed that EcPV-2, found in the Chinese horses, was closely related to and clustered together with an already known EcPV-2a lineage. Our study provides the early evidence related to EcPV-2 infection in the Chinese horses, and describes the vertical transmission of EcPV for the first time, which can act as a causative agent for Yili horse abortions. Overall, the findings might lay the foundation for a systematic and detailed epidemiological study of this infection in the Chinese horses.
Prognosis of Gestational Trophoblastic Neoplasia with Uterine Arteriovenous Malformation
Authors: Zhou Qing , Liu Yuantao , Lu Xin , Zhang He , Ma Fenghua , Zhang Guofu
Published: April 2022

Objective: This study investigated the prognosis of gestational trophoblastic neoplasia (GTN) with uterine arteriovenous malformation (UAVM) using contrast-enhanced magnetic resonance angiography(CE-MRA) as well as the correlation between UAVM and the prognosis for GTN to determine how to treat these diseases more effectively. Methods: Forty-four patients with GTN at Obstetrics & Gynecology Hospital of Fudan University from December 2015 to December 2020 were selected. Imaging characteristics of conventional magnetic resonance imaging and contrast-enhanced magnetic resonance angiography (CE-MRA) before treatment, treatment methods, and the prognosis were followed-up. Results: A total of 44 cases were included, including five cases of placental site trophoblastic tumor (PSTT) and 39 cases of GTN. There were two cases of PSTT combined with UAVM and 23 cases of GTN combined with UAVM. Thirty-nine cases of GTN were divided into two groups according to the presence or absence of UAVM. Data regarding the β-human chorionic gonadotropin value (<10,000 mIU/mL and ≥10,000 mIU/mL) were evaluated using Chi-square test (P = 0.001); the difference was statistically significant (P < 0.05). There was no significant difference in the International Federation of Gynecology and Obstetrics (FIGO) stage between groups (P > 0.05). The average FIGO scores of the two groups were 4.19 (±3.69) and 6. 70 (±3.39) (P = 0.035); the difference was statistically significant (P < 0.05). Conclusion: The use of CE-MRA is helpful when diagnosing UVAM. The formation of UVAM is related to the prognosis score. The higher the prognosis score, the greater the possibility of UAVM.
Automated external defibrillators and basic life support practices in secondary schools: A nationwide study
Authors: Abela Mark , Grech Victor , Sammut Mark Adrian
Published: April 2022

AimCardiac arrest prevention in schools has recently gained momentum. The survival benefit in schools who have access to defibrillators is clear, with far better survival outcomes in children or adults who sustain a cardiac arrest on school grounds. The main objectives of this study were to assess sudden cardiac arrest (SCA) prevention in Maltese schools, specifically the availability of defibrillators and staff competence in delivering resuscitation.Methodology and resultsAn online based questionnaire was distributed to all secondary schools across the Maltese archipelago. Data was collected, tabulated, and analysed using SPSS V.23. Most schools (n=40, 74.1%) completed the questionnaire. Two schools documented a SCA in the past 10 years. 87.5% agreed that SCA prevention is an important health topic. Most have a defibrillator on the premises (n=37, 92.5%). Only 1 defibrillator is usually available (n=27, 75.0%). Despite the majority claiming its ease of accessibility (n=35, 97.2%), most where not available on every floor (n=37, 97.2%). Only a third were close to a sporting facility (n=11, 30.6%). Schools do not organise regular resuscitation courses (n=21, 58.3%), with 8 schools having five or more certified staff members (23.5%). The number of defibrillators did not influence the frequency of CPR courses at school (p=0.607) and there was no association with the number of certified individuals (p=0.860). ConclusionDefibrillators are not readily available at secondary schools and are often installed in low risk areas. Most schools have only one staff member certified in resuscitation. These factors should be addressed with urgency.
Performance Evaluation and GGEbiplot Analysis of Sesame (Sesamum indicum L.) Genotypes in Eastern Ethiopia
Authors: Hassen Mohammed
Published: April 2022

Background
Sesame is an oil, a food source and cash crop. Even though, there is a lot of potential for sesame production in Ethiopia, the average seed yield of sesame is very low due to a lack of high yielder improved sesame variety/ies. As a result, the goals of this study were to assess the performance of sesame genotypes and GGEbiplot analysis.
Materials and Methods
in a randomized complete block design with three replications, fifteen sesame genotypes, including check (Adi), were tested during the main cropping season (2014, 2015 and 2016) at three sesame growing locations: Werer, Bonta (Arage), and Miesso.
Results and Discussion
Serkamo white (G12) and Acc-44(1) (G14) performed better than the other genotypes. As a result, its main advantages over the other genotypes tested were its higher grain yield and white seed color.
Conclusion
Serkamo white (G12)genotype are expected to grasp high external market preferences and prices due to their seed yield and white seed color, contributing to the future sesame export market.
Systematic review of antimicrobial activities of medicinal plants against bacterial and fungal microbes: A research trend in Africa from 1980 to 2019
Authors: Achilonu Conrad Chibunna , Udensi Ogbuagu Ugorji
Published: April 2022

Antimicrobial resistance to typical antibiotics is a significant threat to human health worldwide, and its rapid progression have raised serious concern in the treatment of infectious diseases. The cost of commercialising a new antibiotic is high relative to a low return on investment. Medicinal plants are used for the treatment of infections in many countries and are customarily recognised in Africa. Many studies have shown that phytochemicals produced by plants have exerted potential antimicrobial activities against pathogens through various action mechanisms. However, crude extracts from medicinal plants may be an alternative source of antimicrobial resistance modifying agents because of the large range of bioactive compounds. This systematic review aims to assess published articles in Africa on medicinal plants with potential antimicrobial resistant effectives, focusing on bacterial and fungal microbes. To assess this studies, bibliometric model on Scopus and Web of Science databases were used to systematically search for “Antimicrobial Activity’ or “Medicinal Plants” as titles for studies published from 1980 to 2019 in Africa. We identified a total of 2,174 published documents retrieved from 710 sources between 1980 to 2019, and there was an increasing trend of publications over the years. A stringent selection process was established based on clear inclusion and exclusion criteria, yielding 138 data of the most represented medicinal plants, grouped by family and species names. A total of 52 bacterial and 27 fungi were generated in these studies. Egypt, Nigeria, and South Africa were the most represented single and multiple countries with publication, and highest citation counts. In terms of country, Egypt and South Africa had the highest collaborative strength. Most relevant research of 43 articles were published in the Journal of Heterocyclic Chemistry, with Victor Kuete as the 20th most productive author. Natural Product Research was least Journal with 17 published articles. This systematic review study depicts the progression of antimicrobial resistant studies from medicinal plants in Africa and the noticeable research outcomes at current. The study also provided perspectives for future research, pharmaceutical companies, policy makers, research funders, policy makers, and researchers.
Augmented Reality in der Hochschullehre
Authors: Wyss Corinne , Furrer Florian , Degonda Adrian , Bührer Wolfgang
Published: April 2022

Augmented Reality (AR) ist eine Technologie zur Ergänzung und Überlagerung der realen Welt mit virtuellen Informationen. Hierzu stehen verschiedene Technologien zur Verfügung. Zu diesen zählen nebst Smartphones auch Smartbrillen, Head-Mounted Displays und weitere Geräte. In den letzten Jahren erfuhr AR im Bildungsbereich vermehrt Beachtung. Obwohl die Anzahl an Projekten und Publikationen hierzu inzwischen immens gestiegen ist, bestehen immer noch Forschungslücken in Bezug auf generelle didaktische Aspekte von AR im Unterricht sowie zur Lehrpersonenbildung. Dies ist ein bedeutendes Defizit, da Lehrpersonen der entscheidende Faktor für eine hochgradige Integration digitaler Medien in den schulischen Unterricht darstellen und damit die Digitalisierung der Volksschule konkret beeinflussen. Der Beitrag widmet sich deshalb diesem Thema und beschäftigt sich mit dem Lehren und Lernen mit AR-Anwendungen im Rahmen der Lehrpersonenbildung. Es wird vorerst eine Begriffsklärung sowie ein Überblick über die zentralen Erkenntnisse zu AR im Bildungsbereich erarbeitet und erläutert, welches Potenzial und welche Herausforderungen der Technologie zugeschrieben werden. Darauf aufbauend werden didaktische Überlegungen und konkrete Bildungsziele für den Einsatz von AR in der Lehrpersonenbildung dargelegt. Der Beitrag soll damit eine anregende Grundlage bieten, um den Einsatz von AR in der Lehrpersonenbildung zu reflektieren und weiterzuentwickeln.
KECERDASAN SPIRITUAL DALAM PRESTASI KERJA KARYAWAN
Authors: Yogatama Ahmad Nizar
Published: April 2022

This study aims to determine the effect of work environment, spiritual intelligence and workload on employee performance at University of Muhammadiyah Malang alumni class of 2007 faculty of economics and business management majors. The results showed that the work performance of employees by University of Muhammadiyah Malang alumni in the year 2007 of the Economics and Business faculties majoring in management was influenced by the spiritual intelligence of each individual, while the work environment and workload had no effect. This is due to high spiritual intelligence that will make individuals have more meaning in addressing work and things that will be received by employees in the future. This study uses multiple linear regression analysis using primary data collected through social media whatsapp.
PEMASARAN SYARIAH BERBANTUAN MEDIA SOSIAL: KONTESTASI STRATEGIS PENINGKATAN DAYA JUAL
Authors: Muali Chusnul , Nisa’ Khoirun
Published: April 2022

The emergence of instant products has a major impact on people's perspectives and behavior. Many people do not want to be difficult in owning a house, so PT Karya Cipta Sakinah uses this great opportunity to build a medium-sized business that is engaged in the developer. The business that was carried out began with the use of own capital which is now expanding into a larger business aimed at supporting the government's "Million Houses" program. The sharia marketing strategy implemented by PT Karya Cipta Sakinah which prioritizes sharia elements brings a lot of blessings, this has a big impact on the increase in consumer response and blessed profit. PT Karya Cipta Sakinah initially used promotional strategies through print media which were considered less effective. And now increasingly expanding its wings by using a Facebook account as an accurate means of proper promotion to facilitate the delivery of business product information to the wider community. In this case the researcher uses the research method "Qualitative Descriptive Analysis" with data collection techniques "observation, interviews and documentation"
The occurrence of monoclinic jarosite in natural environments
Authors: Whitworth Anne J. , Brand Helen E.A. , Wilson Siobhan A. , Grey Ian E. , Stephen Natasha R. , Gozukara Yesim , Frierdich Andrew J.
Published: April 2022

Jarosite and related subgroup minerals are of high importance in mineral processing, as sources and sinks for metals and acidity in the environment, and they have the potential to preserve elemental and isotopic biomarkers relevant to the search for life in the solar system. The crystal structures and chemistry of jarosite minerals affect their stability and reactivity and thus the roles they play in natural and engineered systems. Rhombohedral symmetry has been documented in natural and synthetic jarosites, whereas monoclinic symmetry has only been documented in synthetic jarosites. This research reports the occurrence of monoclinic symmetry in a natural natrojarosite sample investigated using synchrotron powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), and electron backscatter diffraction (EBSD). Splitting of several rhombohedral PXRD peaks (e.g., 012, 027, and 033) into pairs of peaks was observed, with the magnitude of the splitting and the relative intensities of the pairs of peaks being almost identical to those reported for synthetic monoclinic jarosite. Rietveld refinement with room-temperature PXRD data shows an ordering of iron-site vacancies on the Fe1 site consistent with monoclinic symmetry, space group C2/m. Conversion of monoclinic unit-cell parameters into pseudo-hexagonal unit-cell parameters, specifically β′, also supports the use of a monoclinic model to describe the natrojarosite structure. Structural analysis with increasing temperature is supportive of the thermal evolution previously described for synthetic monoclinic jarosite samples, with some indications of subtle differences between synthetic and natural materials including slower rates of thermal expansion and absence of FeOHSO4 peaks for natural monoclinic jarosite. EBSD provides insight into the spatial–structural variation within the hand specimen from which the natrojarosite was sampled, demonstrating that there are areas of unambiguous monoclinic symmetry, but others where both monoclinic and rhombohedral natrojarosite coexist. The results of this study suggest that monoclinic symmetry in natural jarosites may be more prevalent than previous studies suggest. Monoclinic symmetry in jarosites is identifiable by an ordering of iron-site vacancies on the Fe1 site, splitting of specific rhombohedral XRD peaks into pairs of peaks, and an increase in jarosite symmetry (i.e., from monoclinic to rhombohedral) during heating. The splitting of peaks in monoclinic jarosites can be subtle so it is recommended that high-resolution XRD data are collected when studying the crystal structure of jarosites.
Tourmaline and zircon trace the nature and timing of magmatic-hydrothermal episodes in granite-related Sn mineralization: Insights from the Libata Sn ore field
Authors: Vincent Victor I. , Li Huan , Girei Musa B. , Förster Michael W. , Kamaunji Vandi D.
Published: April 2022

The Bin Yauri-Libata polymetallic ore district is a Sn and Au ore-bearing district in the Zuru schist belt, Northwestern Nigeria. The Libata Sn ore field is characterized by a set of cassiterite-bearing hydrothermal veins associated with Neoproterozoic Pan-African granites affected by deformation and low-grade metamorphism. The hydrothermal alteration associated with cassiterite-bearing quartz veins in the Libata deposit includes silicification, albitization, chloritization, and potassic alteration. In this study, geochemical and geochronological data from tourmalines and zircons from Sn-bearing lodes, unmineralized and altered granites is applied to reveal the timing, fluid composition, and source of ore-forming materials for tin mineralization in the Libata ore field. Zircon trace element and Hf isotopes [εHf(t) = +4.37 to +10.85] reveal a mantle-derived source with some crustal contribution for the melts forming the Libata Sn-bearing granites. LA-ICP-MS zircon U-Pb dating constrains the magmatic and hydrothermal ages to 650–646 and 649–646 Ma for the Libata granites. Overlapping zircon εHf(t) and 176Hf/177Hf but distinct 176Lu/177Hf and 176Yb/177Hf ratios from magmatic and hydrothermally altered zircons reveal a magmatic source for the hydrothermal fluids which triggered cassiterite deposition in the Libata ore field. Major element chemistry constrain tourmalines from the Libata ore field as schorls that show high alkalis, low-Ca contents, and moderate ☐ values (where ☐ is x-site vacancy). High Li, Zn, and Sn concentrations in tourmaline as well as Li/Sr and Ca-Fe-Mg ratios demonstrate that the tourmaline formed from granite-sourced fluid likely derived from the host Libata granites. Measured δ11B values from the Libata tourmaline range from –15.7‰ to –14.1‰. The δ11B of the mineralizing fluid is estimated to be –13.1 to –11.9‰ for the Libata tourmalines at 400–500 °C and overlaps with averages from fractionated granites worldwide. Therefore, our data show that tourmaline and zircon are useful tracers of magmatic-hydrothermal evolution in rare-metal-bearing granite systems.
Intellectual capital components and industrial firm’s performance
Authors: Fawzi Shubita Mohammad
Published: April 2022

The study aims to determine the connection between intellectual capital (IC) and financial performance of the Jordanian industrial listed companies. The methodology uses regression models, the IC will be measured using the VAIC model (value-added intellectual coefficient), on the other hand, company performance will be measured using return on equity (ROE). The main model includes financial leverage as a control variable to study the leverage role in the association between IC and return on equity. The study also investigates the incremental information content for intellectual capital components in explaining the change in firm performance. In addition, the size effect is studied to show if the company’s size affects the link between ROE and IC. The sample for this study is 77 Jordanian industrial firms and 788 company-year observations during the period 2006–2020. The study results are as follows: Intellectual capital has an important influence on industrial firm performance; Intellectual capital components have a significant impact on industrial firm performance. In particular, human capital efficiency (HCE) and capital employed efficiency (CEE) have a positive influence on ROE, and structural Capital efficiency (SCE) has a negative impact on firm performance. Lastly, firm size has an effect on the relationship between IC and industrial company performance.
INOVASI PENGOLAHAN IKAN BERBASIS VARIASI PRODUK FOOD SECURITY BAGI NELAYAN TELUK KECAMATAN LABUAN KABUPATEN PANDEGLANG PROVINSI BANTEN
Authors:   Universitas Sultan Ageng Tirtayasa, Jl. Raya Palka No.Km 3, Panancangan, Kec. Cipocok Jaya, Kabupaten Serang, Banten 42124, Fauzi Ahmad
Published: April 2022

Studi pendahuluan yang dilakukan diperoleh informasi bahwa permasalahan yang dihadapi oleh Masalah umum yang muncul pada masyarakat kelompok usaha pengolahan ikan yaitu terbatasnya pengetahuan produksi olahan ikan, rancang bangun, dan manajemen dalam hal pengolahan variasi makanan ikan, seperti: ikan asin, ikan pindang, otak-otak. Hasil pengamatan langsung (20 Agustus 2018), usaha pengolahan ikan sudah ditekuni turun-temurun dari keluarga dimana hasil penjualan mengalami penurunan dari tahun ke tahun dikarenakan perubahan iklim cuaca dan belum adanya teknologi yang mendukung untuk menunjang produksi variasi makanan. Oleh karena itu diperlukan pengetahuan produksi olahan ikan, rancang bangun, dan manajemen pengelolaan wirausaha, sehingga pengolahan ikan lebih maksimal. Metode pendekatan yang digunakan dalam kegiatan PKM adalah pertama pendampingan yang dilakukan melalui sosialisasi dan FGD untuk memberikan pemahaman tentang potensi sumber daya alam berupa ikan yang melimpah dihasilkan oleh nelayan desa teluk yang bisa dimanfaatkan atau diolah menjadi berbagai macam makanan dan kerajinan tangan. Kedua kegiatan pelatihan pengolahan ikan berbasis food security menjadi makanan dan kerajinan tangan yang diajarkan praktek mengenai pengoalahan ikan menjadi makanan berupa nugget, bakso, sosis, empek-empek, dan otak-otak sedangkan pengolahan ikan menjadi kerajinan tangan berupa bunga hias dan perhiasan imitasi serta pelatihan mengenai manajemen keuangan sederhana. Luaran yang akan dicapai dari kegiatan ini adalah meningkatkan pengetahuan dan keterampilan penerima manfaat dalam mengolah ikan menjadi beberapa jenis produk yang bernilai sehingga dapat membantu dalam perekonomian keluarga. Serta produk dari ikan yang dihasilkan berupa makanan dan kerajinan tangan.
GERAKAN DONASI BUKU DALAM UPAYA MEMBANGUN BUDAYA LITERASI : TAHAP 1
Authors:   Sistem Komputer, Universitas Serang Raya, Rosalina Vidila , Hikmatullah Hikmatullah ,   Pegiat Literasi, TBM Cilegon, Oktri Widiyanto Wahyu ,   Teknik Industri, Universitas Serang Raya, Fernando Donny ,   Sistem Informasi, Universitas Serang Raya, Harsiti Harsiti ,   Sistem Informasi, Universitas Serang Raya
Published: April 2022

The society of a nation has a vertical relationship to the quality of the nation. The high interest in reading someone's book influences one's insight, mentality, and behavior. The Indonesian nation is a nation with a low literacy level even though it has been 70 years since Indonesia became an independent country. There are many factors why Indonesian society's literacy has a low percentage. These problems must immediately get serious attention not only from the government but from all of us. How does the discourse about "interest in reading" be carried out for all people when we still have a limited number of books read? So the book donation movement is in an effort to build a culture of literacy and literacy in Indonesia and in Banten in particular. When the state of literacy becomes a culture in Indonesia, it is not impossible that our nation will be an advanced nation.
PENGGALIAN POTENSI USAHA BUMK HENDRO MULYO, LAMPUNG TENGAH
Authors:   Politeknik Keuangan Negara STAN, Kurnianingsih Puji , Fadila Syuja Andika ,   Politeknik Keuangan Negara STAN, Adi Fahrizal ,   Politeknik Keuangan Negara STAN, Ulfah Prihandini Nabilla ,   Politeknik Keuangan Negara STAN, Kurniawan Reza ,   Politeknik Keuangan Negara STAN, Permita Sari Saraswati ,   Politeknik Keuangan Negara STAN, Raharjo Taufik ,   Politeknik Keuangan Negara STAN, Sunarya Sulaeman Agus ,   Politeknik Keuangan Negara STAN
Published: April 2022

The Village Owned Enterprises (BUMK) Hendro Mulyo was established by the Government of Tempuran Village, Trimurjo District, Central Lampung Regency. Although it is strategically located, BUMK has not been able to explore business potential following the conditions of the local community. The purpose of this community service activity is to explore the potential of the village as a form of BUMK business and make a Budget Plan for BUMK businesses. The result of community service activities is that BUMK management has established a business form and can plan their business budget.
Mutational Analysis of Interleukin-11 and its Consequences on Cancer and
COVID-19 Related Cytokine Storm -An Extensive Molecular Dynamics
Study
Authors: Ray Sujay , Luharuka Shreya
Published: April 2022

Background:

Interleukin-11 is a pleiotropic cytokine that is known to play an important
role in the progression of various forms of cancer by modulating the survival and proliferation of
tumour cells. IL11 also demonstrates a structural homology to IL6, the predominant cytokine
involved in COVID-19. This makes IL11 a potential therapeutic target in both diseases.

Objective:

This study aimed to evaluate the impact of the two-point mutations, R135E and R190E,
on the stability of IL11 and their effect on the binding affinity of IL11 with its receptor IL11Rα. It is
a molecular level analysis based on the existing experimental validation.

Method:

Computer-aided drug designing techniques, such as molecular modelling, molecular
docking, and molecular dynamics simulations, were employed to determine the consequential
effects of the two-point mutations.

Results:

Our analysis revealed that the two mutations led to a decrease in the overall stability of
IL11. This was evident by the increased atomic fluctuations in the mutated regions as well as the
corresponding elevation in the deviations seen through RMSD and Rg values. It was also
accompanied by a loss in the secondary structural organisation in the mutated proteins. Moreover,
mutation R135E led to an increase in the binding affinity of IL11 with IL11Rα and the formation of
a more stable complex in comparison to the wild-type protein with its receptor.

CONCLUSION:

Mutation R190E led to the formation of a less stable complex than the wild-type,
which suggests a decrease in the binding affinity between IL11 and IL11Rα.
miR-638: A Promising Cancer Biomarker with Therapeutic Potential
Authors: Hasheminasabgorji Elham , Mishan Mohammad Amir , Tabari Mohammad Amin Khazeei , Bagheri Abouzar
Published: April 2022

Background:

There is an unmet need to improve the diagnosis of cancer
with precise treatment strategies. Therefore, more powerful diagnostic, prognostic, and
therapeutic biomarkers are needed to overcome tumor cells. microRNAs (miRNAs,
miRs), as a class of small non-coding RNAs, play essential roles in cancer through the
tumor-suppressive or oncogenic effects by post-transcriptional regulation of their targets.
Many studies have provided shreds of evidence on aberrantly expressed miRNAs in
numerous cancers and have shown that miRNAs could play potential roles as
diagnostic, prognostic, and even therapeutic biomarkers in patients with cancers.
Findings have revealed that miR-638 over or underexpression might play a critical role in
cancer initiation, development, and progression. However, the mechanistic effects of
miR-638 on cancer cells are still controversial.

Conclusion:

In the present review, we have focused on the diagnostic, prognostic, and
therapeutic potentials of miR-638 and discussed its mechanistic roles in various types of
cancers.
Potential Neuroprotective Effect of Cannabinoids in COVID-19 Patients
Authors: Cortes-Altamirano José Luis , Yáñez-Pizaña Ariadna , Reyes-Long Samuel , Angélica González-Maciel , Bandala Cindy , Bonilla-Jaime Herlinda , Alfaro-Rodríguez Alfonso
Published: April 2022

The global pandemic caused by the SARS-CoV-2 virus began in early 2020 and is still
present. The respiratory symptoms caused by COVID-19 are well established. However, neurological
manifestations that may result from direct or indirect neurological damage after SARS-CoV-2
infection have been reported frequently. The main proposed pathophysiological processes leading to
neurological damage in COVID-19 are cerebrovascular disease and indirect inflammatory/
autoimmune origin mechanisms. A growing number of studies confirm that neuroprotective
measures should be maintained in COVID-19 patients. On the other hand, cannabinoids have been
the subject of various studies that propose them as potentially promising drugs in chronic neurodegenerative
diseases due to their powerful neuroprotective potential. In this review, we addresses
the possible mechanism of action of cannabinoids as a neuroprotective treatment in patients infected
by SARS-CoV-2. The endocannabinoid system is found in multiple systems within the body, including
the immune system. Its activation can lead to beneficial results, such as a decrease in viral
entry, a reduction of viral replication, and a reduction of pro-inflammatory cytokines such as IL-2,
IL-4, IL-6, IL-12, TNF-α, or IFN-c through CB2R expression induced during inflammation by
SARS-CoV-2 infection in the central nervous system.
The Synthesis of 2-substituted Benzo[b]furans Catalyzed by Ni/5-Bromo-
2,2’-bipyridine
Authors: Rong Zhou , Yu-qin Li , Yan-li Ding , Xiao-li Qin , Jing Sha , Ping Li , Lu Jin , Huan-huan Wang
Published: April 2022

A tandem system that enabled the synthesis of 2-substituted benzo[b]furans from 2-
halophenols and aryl acetylenes catalyzed by Ni/5-bromo-2,2’-dipyridine was explored. The protocol
was found effective for one-pot cascade coupling cyclization reaction producing benzo[b]furan
compounds, and heteroaryl substrates were observed to be compatible for this system as well, giving
corresponding products in 20-70% yields.
Diet and Gestational Diabetes Mellitus: A Systematic Review Study
Authors: Alamolhoda Seideh-Hanieh , Zare Elham , Mirabi Parvaneh
Published: April 2022

Objective:

Diet may have an impact on gestational diabetes mellitus (GDM) development;
nevertheless, controvertible studies have been published. The aim of this study was to provide
evidence from analytical studies on the relationship between diet and GDM development.

Methods:

Following the PRISMA guidelines, ISI Web of Knowledge, PubMed, Google Scholar,
Scopus, Embase, and the Cochrane library were searched for articles published in the English language
from Jan 2005 to Dec 2020. We included observational studies, assessed their risk of bias,
and extracted data on association between diet status and GDM development. Keywords were selected
based on the Mesh terms, which included gestational diabetes mellitus“, “GDM”, “diet,” “nutrition,”
“food,” “dietary pattern which was combined by "OR" and "AND" Boolean operators. Two
reviewers (SHA and PM) independently reviewed abstracts and full-text articles and extracted data.

Results:

Among the 5 articles included, 4 were case-control and one was a cross-sectional study.
Studies have shown that diets with a high intake of saturated fatty acids (more than 10% of total daily
fat intake) and trans fatty acids (more than 1% of total daily fat intake) before and during pregnancy
significantly increase the risk of gestational diabetes mellitus.

Conclusion:

High intake of saturated fat and trans fat before and during pregnancy can disturb glucose
metabolism and increase the risk of GDM, although all of the studies recommend more widespread
observational and clinical trials studies to identify the exact relationship between high saturated
and trans fatty acids intake and GDM.
The Endocannabinoid System as a Biomarker for Diagnostic and Therapeutic
Applications in Depression and Anxiety
Authors: Murillo-Rodríguez Eric , Alcaraz-Silva Jocelyne , Feingold Daniel , Viana-Torre Gerardo , Budde Henning , Imperatori Claudio , Machado Sérgio
Published: April 2022

Background:

Depression and anxiety belong to a family of mental disturbances that have
increased significantly in recent years. The etiology of both disorders comprises multiple and complex
factors, from genetic background to environmental influence. Since depression and anxiety present severe
symptoms, they represent a greater clinical burden and greater therapeutic difficulty. Currently,
standardized diagnostic procedures for depression and anxiety allow for the addition of further treatments,
including psychotherapy and/or pharmacological intervention, with effective outcomes. However,
further steps should be considered with regard to consideration of the endocannabinoid system’s
role in depression and anxiety.

Objective:

This study aimed to review the evidence from animal research and clinical studies on the role
of cannabinoid receptors, the major endocannabinoids -anandamide (AEA) and 2-arachidonoylglycerol
(2-AG)- and the enzymes related to the synthesis and degradation of these chemicals as putative biomarkers
for diagnostic and therapeutic elements of depression and anxiety.

Method:

This review included the online search, identification, and analysis of articles (basic and
clinical trials) published in English in PubMed linked to the role of cannabinoid receptors, AEA, 2-
AG, and the enzymes associated with the synthesis and degradation of these endocannabinoids in depression
and anxiety.

Results:

The neurobiological relevance of the endocannabinoid system offers genetic or pharmacological
manipulation of this system as a potential strategy for the diagnostic and clinical management of
mood disorders, including depression and anxiety.

Conclusion:

Although the described approach in this review is promising, no solid evidence is yet
available, and along with additional experiments using animal models that mimic human depression
and anxiety, clinical trials are needed to explore the role of the endocannabinoid system’s elements as
well as the anandamide membrane transporter, none of which have been adequately studied in depression
and anxiety.
A five-year follow up of doctors treating relatives and themselves
Authors: Atalla, BS Jasmyn E. , DeChant, MD Ross D. , Goebel, MD, FACP Lynne J. , A. Mufuson, MD, MACP Corresponding Author: Maurice
Published: April 2022

Studies show high rates of physicians believing that they should treat relatives and themselves In this study, we compared such attitudes in surveys conducted in 2017 and 2012 among similar populations of physicians who attended Internal Medicine, Pediatrics, Family Medicine, and OB/ GYN Grand Rounds. Fewer respondents in 2017 prescribed medications to relatives without an examination. Similar numbers of residents and faculty in both years believed they should treat their relatives. Fifty-nine percent treated relatives for minor illnesses, a significant decrease from 75.3% in 2012. About half of physicians treated themselves for minor illnesses in both years. Although 73% of current respondents had a primary care physician (PCP), a significantly higher proportion of men had PCPs (p-0.04) in 2017 in contrast to a significantly higher proportion of women in 2012 (p=0.01). The overall frequency of residents and faculty physicians who treat relatives and themselves decreased in the past five years and less treat without examination. However, too many physicians continue this practice, despite the ethical admonitions of the AMA and ACP. More education is required to convince physicians not to treat relatives and themselves. Further research is needed to determine why men now have PCPs more often than women.
Building New Nuclear in Finland: Crises Challenging Core Beliefs around Nuclear Energy
Authors:   Centre for European Studies, University of Helsinki, Helsinki, Finland, Lounasmeri Lotta
Published: April 2022

This paper examines the building of a new nuclear plant as a greenfield operation in Pyhäjoki, Finland. A newly-founded energy company, Fennovoima, was granted a license by the Finnish parliament to build a new power plant in 2010. In the years following this Decision in Principle the project faced several obstacles. Through interviews with key actors, this paper identifies the interests and core beliefs associated with building the plant. It posits that, in Finland, the underlying ideas and values surrounding nuclear energy are deeply embedded in conventional belief, or ‘doxa’-like, and as such are very difficult to challenge or change. Through the lens of this example, it offers suggestions and conclusions concerning the more general social logic behind energy policy decisions in the Finnish context and why nuclear energy has become a hegemonic solution in the Finnish polity. The paper also discusses the viewpoint of geopolitics, which has had historical relevance and has become of paramount concern in the current world situation.