bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphofunctional condition of palatine tonsils in various forms of chronic tonsillitis
Authors: Pal’chun V. T. , Kriukov A. I. , Gurov A. V. , Dubovaya T. K. , Ermolaev A. G.
Published: November 2020

Introduction. According to different authors, 4 to 40% of the child and adult population suffer from chronic tonsillitis (СT), with many authors noting an increase in the number of cases and no tendency to decrease the frequency of this pathology.

Objective. To optimize diagnostics and treatment tactic of taking patients with chronic tonsillitis (CT) using our own clinical and laboratory data and morphological data as well as literature data.

Materials and methods. Аt the first stage of work, 166 patients were examined. They were divided into 4 categories (experimental groups) depending on clinical CT classification according to B.S. Preobrazhensky and V.T. Palchun. We also formed a group of patients who did not have CT symptoms. All patients underwent tonsillectomy or tonsillotomy. All tissue samples of palatine tonsils we got were investigated using immunohistochemical markers and default histological colorings. At the second stage, the dynamics of complaints, clinical symptoms and laboratory parameters were assessed in 247 patients diagnosed with CT Toxic-Allergic Form I (CT TAF I) before conservative treatment and 3 months after conservative treatment. Patients were divided into 3 groups depending on the conservative treatment regimen: a course of flushing the lacunae of the tonsils; antibiotic therapy with a retard form of clarithromycin; complex treatment combining the first two options.

Results. Тhe chronic inflammatory process in the palatine tonsils changes their cytoarchitectonics. At the same time, there is a direct correlation between the presence and severity of changes with the clinical classification of chemotherapy according to B.S. Preobrazhensky and V.T. Palchun.

Conclusion. With CT TAF II, the palatine tonsil not only loses its importance as an organ of the immune system, but also becomes a hotbed of infection in the body, which can cause severe complications. Only tonsillectomy can effectively protect the patient from these complications. At the stage of CT TAF I, the formation of metatansillar complications occurs. Patients with this form of CT require special attention, and correctly conducted conservative therapy can protect patients from local and general complications of CT. A variant of such conservative therapy that gives a lasting effect is complex therapy with washing the lacunae of the palatine tonsils with an antiseptic solution and simultaneous antibiotic therapy with 14-membered macrolides that can accumulate in the lymphadenoid tissue.
The efficacy of silver proteinate in the treatment of acute nasopharyngitis
Authors: Sobolev V. P. , Svistushkin V. M. , Leyzerman M. G. , Magomedov K. R. , Bidanova D. B. , Budagova G. N.
Published: November 2020

Acute nasopharyngitis is the most common reason for visit a doctor, usually benign, self-limited disease. It is also characterized by a high frequency of complications in children and nonspecific symptoms that require special care from the doctor when examining patients. The clinical and social significance of acute nasopharyngitis is due to their high prevalence, and inadequate treatment leads to a protracted course or to a transition to a chronic one. The relevance of this problem adds to the presence of a large number of various drugs, but not many drugs have evidence-based effectiveness. In the treatment of acute nasopharyngitis local drugs are very important. The drug is a silver proteinate agent with broad antibacterial anti-inflammatory activity. The drug is used to treat infectious rhinitis. This article evaluates the use of a new form of the silver proteinatedrug, the drug is available in the pharmacy, easy to use, long shelf life. This article describes the place of silver proteinate among drugs that help to relieve the symptoms of acute nasopharyngitis and provides data on its effectiveness, safety and features of use in children. The drug can take a worthy place among topical drugs due to its high efficiency in the treatment of acute rhinitis and its possible use at any age.
Basic principles for the treatment of chronic rhinosinusitis with nasal polyps
Authors: Savlevich E. L. , Cherenkova V. A. , Molodnitskaia A. Yu.
Published: November 2020

Introduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) is based on a chronic inflammatory hyperplastic process in the mucosa membrane of the nasal cavity and paranasal sinuses (SNPs). According to the consensus on the biological treatment of CRSwNP with or without asthma, which is one of the latest consensus documents of the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), which was published in December 2019, the need for surgical treatment or systemic administration of corticosteroids due to the active nasal polyps growth are conditional signs for the decompensation of clinical control. Currently, the basic treatment for patients with CRSwNP is the long-term use of intranasal corticosteroids (INCS), which leads to an improvement in the quality of life, while minimizing the risk of exacerbations and complications.

Research purpose. To evaluate the effectiveness of the basic therapy of intranasal glucocorticosteroid mometasone furoate for different phenotypes of CRSwNP.

Methods. All patients with recurrent CRSwNP were divided into 3 equal phenotypic groups of 40 people each: group 1 – CRSwNP without asthma and respiratory allergies, group 2 – CRSwNP + atopy, group 3 – CRSwNP + non-allergic asthma. The observation period was 3 years.

Results. Using the algorithm of stepwise therapy of CRSwNP, dynamic monitoring of these patients by an ENT and an allergistimmunologist, basic therapy with corticosteroids with constant treatment correction once every 3 months, it was possible to stabilize the inflammatory process throughout the respiratory tract and reduce the need for surgical treatment.

Conclusion. With CRSwNP, long-term use of Mometasone furoate INCS is the main drug of basic therapy to minimize the recurrence of nasal polyp growth and is accompanied by clinical efficacy and the absence of adverse side effects.
Groundwater Yield Modeling in the Floodplain of Hadejia, Northwestern Nigeria
Authors: Tukur Abubakar , Yusuf Maharazu , Abdulhamid Adnan , Umar Da’u , Isiyaka Hamza , Ramli Mohammad
Published: November 2020

This paper proposed a model explaining variation of shallow groundwater yield and dynamic level with respect to river location in the floodplain of Hadejia, along Hadejia River Basin of Jigawa State, Northwestern Nigeria. To achieve the aim, six transects were established within one km2 of floodplain and were oriented perpendicular to the river channel. Three tube wells were sampled and positioned along each transect at regular intervals making a total of 18 wells. Pumping test, which was repeated four times at 15 minutes interval in both morning and evening hours was used to measure groundwater yield. Multivariate statistical tools such as analysis of variance, Pearson product moment correlation, and cluster analysis were used, respectively, to test the research hypothesis and to classify sampling points into similar groups based on groundwater yield. Results show that the average yield of wells for evening hours recorded a higher yield of 3.3 L/s (55.93%) than the yield in the morning hours of 2.6 L/s (44.07%). Further, the 2-way ANOVA at 5% level of significance showed no significant difference in the groundwater yield related to relative location of wells in morning (p value, 0.30>0.05) and evening (p value, 0.21>0.05) hours. The results of ANOVA revealed no statistically significant difference between the points. It suggests that the adopted model can be applied in other similar sedimentary basins with a view to validating it. A decision support system is recommended among the strategies to improve groundwater resources management in the area.
Dynamics of demand in the labor market in the southern regions of Russia during the COVID-19 pandemic
Authors: Rodicheva Irina V.
Published: November 2020

The events taking place in 2020 in the world in general and in Russia in particular have dramatically shaken up all spheres of public life. The quarantine measures have significantly blocked the channels of business interaction and enabled a pause mode in a wide range of economic processes. The state of the labor market during the crisis period is a defining indicator that demonstrates the strategies of employers and employees. This article studies the dynamics of a key indicator of the labor market — the demand for labor in the southern regions of Russia. The author aims to analyze the dynamics of labor market demand in a number of cities in southern regions of Russia in the key periods of spring 2020 events associated with the COVID-19 pandemic. The analysis covers six cities of southern Russia, located in different regions and significantly different specific structure of the economic sphere. The indicators of the southern regions as a whole were considered separately, which allowed to diagnose their condition and draw conclusions about ther particular “painful” dependencies. The labor market of the southern Russian cities is characterized by stable seasonality structures and highly specialized orientation in a number of territories. These private characteristics have a direct impact on complex economic indicators. The eployment of quarantine measures on the eve of the holiday season and preventive saturation with epidemiological security measures of the tourist business in the country threatened to turn into an economic disaster for a number of territories. The novelty of this topic lies in the fact that the forced lockdown had an external character and it highlighted a significant dependence of economic actions of business on the decisions of the authorities. The new conditions of destabilization were a test of stability of organizational links of different spheres of public life. An essential factor that destabilized the behavior of key labor market participants was the mass media, which spread false or unverified information. The author draws a conclusion about the characteristic avalanche-like declines and rises in demand in the labor market of the southern regions and about the uneven distribution of reactions in different cities with similar geographical locations.
Multifunctional RNase MCPIP1 and its Role in Cardiovascular Diseases
Authors: Yan Binjie , Guo Yanan , Gui Yu , Jiang Zhi-Sheng , Zheng Xi-Long
Published: November 2020

Monocyte chemoattractant protein-1 induced protein 1 (MCPIP1), one of the
MCPIP family members, is characterized by the presence of both C-x8-C-x5-C-x3-H (CCCH)-
type zinc finger and PilT-N-terminal domains. As a potent regulator of innate immunity,
MCPIP1 exerts anti-inflammatory effects through its ribonuclease (RNase) and
deubiquitinating enzyme activities to degrade cytokine mRNAs and inhibit nuclear factor-
kappa B (NF-κB), respectively. MCPIP1 is expressed not only in immune cells but also
in many other cell types, including cardiomyocytes, vascular endothelial cells (ECs)
and smooth muscle cells (SMCs). Increasing evidence indicates that MCPIP1 plays a
role in the regulation of cardiac functions and is involved in the processes of vascular diseases,
such as ischemia-reperfusion (I/R) and atherosclerosis. To better understand the
emerging roles of MCPIP1 in the cardiovascular system, we reviewed the current literature
with respect to MCPIP1 functions and discussed its association with the pathogenesis
of cardiovascular diseases and the implication as a therapeutic target.
UCP2 and CFH Gene Variants with Genetic Susceptibility to Schizophrenia in Turkish Population
Authors: Nursal Ayse Feyda , Aydin Pinar Cetinay , Pehlivan Mustafa , Sever Ulgen , Pehlivan Sacide
Published: November 2020

Objective:

Schizophrenia (Sch) is a complex, multifactorial psychiatric disorder. Growing evidence shows that
oxidative damage and immunological dysfunction exist in the Sch physiopathology. In the present study, we aimed to evaluate
whether the Uncoupling protein 2 and Complement factor H gene variants play any role in susceptibility to Sch.

Methods:

This study was carried out on 200 individuals (100 Sch patients and 100 healthy controls). Genomic DNA was extracted
from blood samples.UCP2-866G /A (rs659366) and CFHY402H variants were analyzed by PCR-RFLP analysis.

Results:

The UCP2 -866G/A variant G/G genotype and G allele were associated significantly with increased risk of Sch
(p=0.001, p=0.001, respectively). The subjects carrying UCP2 -866G/A variant G/G genotype had 4.377-fold increased risk
for Sch.There was no significant difference between the groups for the genotype and allele frequencies of CFH Y402H variant
(p>0.05). The observed genotype counts deviated significantly from those expected in Sch patients according to the
HWE for UCP2 -866G/A variant (p=0.001).

Conclusion:

We present the first results investigating UCP2 -866G/A/ and CFH Y402H variants for susceptibility to Sch in
a Turkish population. These results indicate that the UCP2 -866G/A, but not CFH Y402H variant, might play an important
role in the development of Sch.
State and prospects of development of technical support for cryotherapy treatment
Authors: Shakurov A. V. , Kolyshkin L. M. , Andreev N. A.
Published: November 2020

Objective. General cryotherapy effect on the human body with cooling gas is a physiotherapy method, the positive effect of which has been proven for more than 40 years of use (including in Russia, which is one of the leaders in this field). The objective of the study was to assess the prospects for the development of technical support for cryomedical effects on human organs. Methods. The work presents an overview and analysis of the current state of the technical support of this cryomethod. Results. The prospects for the method development and directions for improving the equipment are shown. It is noted that the development of the method is limited primarily by the lack of accuracy of cryotherapy and relatively high cost. Conclusion. Low-temperature therapeutic equipment can potentially be located not only in medical, cosmetology, sports facilities but also in office centers. The key in this direction is the development of technical support capabilities, which will further allow practitioners to impulse the development of methods for applying cryotherapy with cooling gas in the mass use of this physical factor in medicine.
User authentication based on the three-stage keyboarding model
Authors: Abzalov A. R. , Kashapov I. I. , Orlov A. Yu. , Mamleev I. R.
Published: November 2020

Objective. The article offers a three-stage model that allows increasing the effectiveness of authentication in the implementation of distance learning systems, not only in automatic proctoring systems but also in complex information systems of critical objects. Methods. Increasing the effectiveness of user authentication is achieved by increasing the accuracy of authentication using keyboarding. Results. The proposed model will help to implement the process of access differentiation for fraudsters and legal users, by adapting to the slightest changes in the keyboarding parameters, which allows increasing the authentication accuracy. During testing, one of the tested users was authenticated using a deviation comparison, while the other three users were authenticated using the χ2 criterion. The remaining users were not able to complete the authentication procedure at all stages of the system. Conclusion. The results of an experimental study showed the high ability of the proposed model of access control for legitimate users and attackers with some minor changes in the parameters of the keystrokes dynamics, improving the accuracy of user authentication. The user authentication reliability in practice was 97.5%.
Independent Magazines Today
Authors: Fazli Sabina , Scheiding Oliver , Anderson Natasha
Published: November 2020

Periodical studies have produced a wealth of research by not only fostering transdisciplinary cooperation but also encouraging the crossing of national and language boundaries. Being grounded in departments of history, literature, culture and area studies ensures the careful and granular reading of issues and the recovery of neglected print archives and personal networks. However, contemporary independent magazines have not yet featured in the scholarly journals of the field. This special issue entiteld "Independent Magazines Today" seeks to highlight the proliferation and vitality of magazines in a niche that is often overlooked, yet deserves closer analysis in order to understand its diversity on and off the page. This introduction first touches on some genealogical aspects of the development of indie aesthetics before discussing independent magazines’ investment in the niche audiences for whom magazines and their aesthetics may serve as a vehicle for diverse contemporary lifestyles. The last section briefly discusses ‘materiality’ and ‘affect’ as two possible key concepts to understanding the workings of indie magazines and their appeal, before introducing the three contributions.
Idiopathische hypercalcemie bij een Perzische kat
Authors: Stock E. , Paepe D. , Verhaert L. , Van De Maele I. , Daminet S.
Published: November 2020

In deze casuïstiek wordt een kat met idiopathische hypercalcemie beschreven. Een mannelijke,gecastreerde Perzische kat van zeven jaar werd aangeboden omwille van partiële anorexie die reedsdrie jaar aanwezig was. Op het bloedonderzoek werd een matige hypercalcemie in combinatiemet hypofosfatemie gezien. Door middel van uitgebreide diagnostiek werd vastgesteld dat de kat‘polycystic kidney disease’ en chronische nierziekte (IRIS fase 2) had. De nierziekte lag echter nietaan de basis van de hypercalcemie gezien de concentratie parathyroïd hormoon normaal was ende kat hypofosfatemie en een gestegen geïoniseerde calciumconcentratie vertoonde. De diagnosevan idiopathische hypercalcemie werd gesteld. De symptomen verdwenen en de calciumspiegelnormaliseerde na behandeling met glucocorticoïden.
Drie gevallen van Hepatozoon canis-infectie bij honden geïmporteerd uit Spanje
Authors: Criel D.
Published: November 2020

Deze casuïstiek beschrijft drie honden afkomstig uit Málaga (Spanje), met een Hepatozoon canisinfectie.De dieren werden bij een Belgische dierenarts aangeboden wegens koorts van onbekendeoorsprong. Op een bloeduitstrijkje werden talrijke gamonten van H. canis waargenomen in deneutrofiele granulocyten. De hond met de meest uitgesproken klinische klachten was bijkomendbesmet met Ehrlichia canis. In dit artikel worden de levenscyclus, klinische bevindingen, diagnostiek,behandelingsmogelijkheden en epidemiologie van H. canis besproken. Gezien het toenemend belangvan importziekten wordt aangeraden H. canis als differentiaaldiagnose te overwegen bij dieren diein endemische gebieden hebben verbleven.
Het couperen van de staart bij lammeren: staarteigenschappen, (contra) indicaties, wetgeving en alternatieve managementmaatregelen
Authors: Driessen B. , Peeters E. , Van Thielen J. , Van Beirendonck S.
Published: November 2020

Hoewel het couperen van de staart bij vrouwelijke lammeren in de Belgische schapenhouderij nog steeds wordt uitgevoerd, dienen er toch vragen over de effectiviteit van het couperen en daardoor ook over de noodzakelijkheid van deze ingreep te worden gesteld. Het couperen van lammerstaarten is eerder te beschouwen als een cosmetische behandeling dan een behandeling ter preventie van myiasis. Om de myiasisincidentie bij schapen effectief te beperken, dient de focus op andere bedrijfsmaatregelen dan het couperen van staarten te worden gelegd. In dit artikel wordt het couperen van lammerstaarten ter discussie gesteld en alternatieven, die al dan niet onmiddellijk implementeerbaar zijn, worden belicht. De dierenarts kan de schapenhouder adviseren om meer doeltreffende managementmaatregelen in de strijd tegen myiasis te nemen. Een frequente controle van de dieren, het beperken van de bevuiling van de achterhand, het preventief gebruik van antiparasitaire middelen, scheermanagement en het gebruik van vliegenvallen zijn daarbij belangrijk.
Tenosynovitis van de sesamschede bij het paard: diagnostiek en behandeling
Authors: Jordana M. , Martens A. , Oosterlinck M. , Vanderperren K. , Pille F.
Published: November 2020

Clinici worden vaak geconfronteerd met kreupele paarden die een opzetting van de sesamschede vertonen. De sesamschede is echter een relatief complexe synoviale structuur die diverse uitdagingen biedt op het gebied van diagnostiek en behandeling van letsels. In dit artikel wordt een overzicht gegeven van de diagnostische en therapeutische aspecten van niet-infectieuze tenosynovitis van de sesamschede.
Neonatale iso-erytrolyse bij de kat
Authors: Snoeck F. , Rijsselaere T. , Van Soom A.
Published: November 2020

Neonatale iso-erytrolyse bij kittens kan enkel voorkomen wanneer de moederpoes bloedgroep B en de kater bloedgroep A of AB heeft. De eerste 24 uur na de geboorte is de darmbarrière bij een kitten open, waardoor na het zuigen antistoffen uit het colostrum in de bloedbaan kunnen opgenomen worden. Een kitten met bloedgroep A neemt anti-A-antistoffen op, waardoor zijn eigen erytrocyten vernietigd worden. Bij symptomen, zoals anemie, hemoglobinurie en icterus, is een bloedtransfusie vaak noodzakelijk. Toch blijft het sterftepercentage heel hoog en is preventie uitermate belangrijk. Daarom dient de bloedgroep van risicorassen steeds vóór het fokken te worden bepaald. Het is af te raden om te fokken met een moederpoes met bloedgroep B en een kater met bloedgroep A of AB. Indien dit wel gebeurt, dient men de kittens 24 uur weg te halen bij de moederpoes, ze te voeden met kunstmelk en subcutaan of oraal serum van een goed geïmmuniseerde poes met bloedgroep A toe te dienen.
Ensaio Sôbre Justiça Distributiva
Authors: Távora Juarez
Published: November 2020

A paz do mundo atual é função de um equilíbrio bipolar de poder, entre o Ocidente democrático e o Oriente soviético. Êsse equilíbrio de poder é instável, por falta de uma terceira fôrça bastante poderosa para funcionar como fiel de balança entre aqueles dois polos, cada um dos quais procura aliciar os elementos esparsos, ainda não polarizados, para ampliar e reforçar, de um lado, a chamada “cortina de ferro”, que envolve o mundo comunista, e, de outro lado, estender e fechar o “cordão de cêrco”, que delineia a política de contenção das potências democráticas.
O Direito brasileiro no exterior
Authors: Wald Arnold
Published: November 2020

Recebemos da Dra. Simonne F. Topcha, advogada em Paris, um fascículodos Jurisclasseurs que ela publicou sôbre o direito brasileiro. São trintapáginas de estudos minuciosos e de inteligente tradução da nossa legislaçãoque assim passa a ter maior divulgação no velho mundo. Além do trabalhorealizado pelos tratados gerais de direito comparado como os de René Davidou de Arminjon, Nolde e Wolff, os pequenos esforços individuais dos pesquisadoresnão devem ser desprezados e pensamos que se trata no caso da melhordas difusões culturais.
Competência legislativa em matéria de funcionário
Authors: Freire Homero
Published: November 2020

Lei estadual criou uma situação jurídica a favor dos funcionários.Não aludiu, restritivamente, aos funcionários estaduais.Teria ela aplicação em proveito dos servidores municipais?
Perda do Direito à Pensão Alimentícia
Authors: E Silva Oliveira
Published: November 2020

A matéria é das mais relevantes e tem merecido pouca atenção no mundoforense. Os que apregoam e defendem a intangibilidade da coisa julgada entendemque, ao Juiz da Primeira Instância, não é possível alterar, em favor domarido, dado um grave motivo superveniente, a parte da sentença que ocondenara a pensionar a companheira, declarada inocente e pobre, no desquitelitigioso.
Controle jurisdicional da administração pelo recurso de excesso de poder
Authors: Gazier François
Published: November 2020

A “Revista do Serviço Público” tem a honra de apresentar, neste número bem como no seguinte, um estudo original do Professor François Gazier sôbre o regime francês de controle da legalidade administrativa, por meio do recurso de excesso de poder. O autor, em razão das eminentes funções que exerce no Conselho de Estado, onde tem funcionado como “Comissaire du Gouvernent” ápice da judicatura administrativa, é autoridade na matéria. Estuda-a, por assim, em têrmos precisos, em estilo de meridiana clareza, e sugestivo. Com essas qualidades, o presente estudo do Professor François Gazier, escrito especialmente para esta Revista, representará a mais atualizada e fidedigna exposição sôhre assunto praticamente desconhecido entre nós, qual seja o regime do controle jurisdicional da administração, fora do juiz comum.
O peculato doloso no direito brasileiro
Authors: Guedes Jorge
Published: November 2020

A palavra peculato é proveniente do têrmo latino peculatus, cuja origem, por sua vez, vem de pecus — (gado) — que constituía a primitiva moeda para realização de compras e pagamento de multas. Com Servio T u llio , em Rema, foi introduzida a moeda cunhada. Daí, então, pela Lex Julia, peculatus, o crime, que antes era furto de gado (no seu significado primário de única riqueza monetária), passou a ser furto de cousas sagradas e desvio pelo funcionário público de dinheiros privados a êle confiados, em razão do cargo.
Development of research on COVID-19 by the World Scientific Community in the first half of 2020
Authors: Tinôco Daniel , Borschiver Suzana
Published: November 2020

The World Scientific Community has carried out several studies on the novel coronavirus, responsible for the current COVID-19 pandemic. This study aimed to verify the development level and research evolution on COVID-19, summarizing experts' main trends in the first half of 2020. The most cited articles focused on understanding the disease, addressing aspects of its transmission, viral activity period, symptoms, health complications, risk factors, and the estimate of new cases. These papers also focused on the treatment/prevention and management of COVID-19. Several drugs and alternative treatments have been investigated, such as the convalescent plasma transfusion and stem cell transplantation, while an efficient vaccine is developed. Prevention and control measures, such as social isolation and immediate case identification, were also investigated. Therefore, the main COVID-19 trends were identified and classified in disease, treatment/prevention, and pandemic management, contributing to scientific understanding and future studies.
Using Character-Level and Entity-Level Representations to Enhance Bidirectional Encoder Representation From Transformers-Based Clinical Semantic Textual Similarity Model: ClinicalSTS Modeling Study
Authors: Xiong Ying , Chen Shuai , Chen Qingcai , Yan Jun , Tang Buzhou
Published: November 2020

Background

With the popularity of electronic health records (EHRs), the quality of health care has been improved. However, there are also some problems caused by EHRs, such as the growing use of copy-and-paste and templates, resulting in EHRs of low quality in content. In order to minimize data redundancy in different documents, Harvard Medical School and Mayo Clinic organized a national natural language processing (NLP) clinical challenge (n2c2) on clinical semantic textual similarity (ClinicalSTS) in 2019. The task of this challenge is to compute the semantic similarity among clinical text snippets.

Objective

In this study, we aim to investigate novel methods to model ClinicalSTS and analyze the results.

Methods

We propose a semantically enhanced text matching model for the 2019 n2c2/Open Health NLP (OHNLP) challenge on ClinicalSTS. The model includes 3 representation modules to encode clinical text snippet pairs at different levels: (1) character-level representation module based on convolutional neural network (CNN) to tackle the out-of-vocabulary problem in NLP; (2) sentence-level representation module that adopts a pretrained language model bidirectional encoder representation from transformers (BERT) to encode clinical text snippet pairs; and (3) entity-level representation module to model clinical entity information in clinical text snippets. In the case of entity-level representation, we compare 2 methods. One encodes entities by the entity-type label sequence corresponding to text snippet (called entity I), whereas the other encodes entities by their representation in MeSH, a knowledge graph in the medical domain (called entity II).

Results

We conduct experiments on the ClinicalSTS corpus of the 2019 n2c2/OHNLP challenge for model performance evaluation. The model only using BERT for text snippet pair encoding achieved a Pearson correlation coefficient (PCC) of 0.848. When character-level representation and entity-level representation are individually added into our model, the PCC increased to 0.857 and 0.854 (entity I)/0.859 (entity II), respectively. When both character-level representation and entity-level representation are added into our model, the PCC further increased to 0.861 (entity I) and 0.868 (entity II).

Conclusions

Experimental results show that both character-level information and entity-level information can effectively enhance the BERT-based STS model.
Web-Based Delivery of the Caregiving Essentials Course for Informal Caregivers of Older Adults in Ontario: Mixed Methods Evaluation Study (Preprint)
Authors: Rottenberg Shelley , Williams Allison
Published: November 2020

BACKGROUND

Many informal caregivers of older adults have limited time because of the number of responsibilities that their caregiving role entails. This population often experiences high levels of burden due to the stressful nature of their work and are vulnerable to developing negative psychological health outcomes. Easily accessible and flexible knowledge interventions are needed to alleviate the burden and stress experienced by this group.

OBJECTIVE

This study aims to evaluate the acceptability of the web-based delivery of the Caregiving Essentials course for informal caregivers of older adults. Both the strengths and limitations of using a web-based platform to provide information and resources were explored to see whether the method of delivery enhanced or hindered the overall course experience for participants.

METHODS

A mixed methodology of web-based pre- (n=111) and postcourse surveys (n=39) and telephone interviews (n=26) was used to collect both qualitative and quantitative data from participants. Individual interviews were also conducted with key stakeholders (n=6), and a focus group was conducted with nursing students (n=5) who were involved in the project.

RESULTS

The web-based delivery of the course provided participants with greater accessibility to the course because it allowed them to work independently through the modules at their own pace wherever and whenever. The discussion boards were also identified as a major strength because of the opportunity for social interaction and the sense of community that many felt through sharing their experiences. Some barriers to participation included age-related factors, issues with navigating aspects of the course, and concerns about privacy and anonymity. Some key suggestions included more engaging methods of web-based communication and the reorganization of the module content to reduce the amount of text and streamline information.

CONCLUSIONS

The web-based delivery of Caregiving Essentials appeared to enhance the overall course experience by increasing accessibility and allowing participants to interact with the learning materials and other caregivers. The findings from this evaluation can be used to create and improve the web-based delivery of both the current and emerging interventions for caregivers.
Measuring affective polarization of online topic-based communities: a computational study on collective anxiety of Weibo (Preprint)
Authors: Yang Yi , Ta Na , Li Kaiyu , Jiao Fang
Published: November 2020

BACKGROUND

The emergence of social media highlights the decentralized nature of information, which means people can be prone to uncertainty and be affectively polarized. A wealth of research around online affective polarization has focused on quantifying anxiety at an individual level, while neglecting that on a collective basis. To address this gap, the manner in which the anxiety of topic-based communities on social media polarizes warrants further examination.

OBJECTIVE

This study aims to gauge the origin and fluctuation in the collective anxiety of topic-based communities on Weibo, and also investigates its correlations with topic characteristics and users’ personal influence.

METHODS

In this paper, researchers proposed a computational model based on neural networks to assess the collective anxiety score of Weibo topic-based communities. The empirical study was based on 200 communities with 403,380 personal accounts and 358,260 messages.

RESULTS

With demonstrated effectiveness of our computational model (85.00% precision and 87.00% recall), we found correlations between the collective anxiety level and the extent to which a certain topic involves public interest, as well as how community members interpret and elaborate the topics on social network platforms. Furthermore, the ratio of influencers might impact anxiety polarization of topic-based communities by setting tones and leading the trends within their groups. More specifically, how close a certain topic is to public interest and people’s conflicting perceptions are responsible for increases of this collective anxiety, while the number of influencers engaged accounts for the decline of its increment.

CONCLUSIONS

This paper examines the manner in which the anxiety of topic-based communities on Weibo platform polarizes. We found the collective anxiety to augment due to topic proximities to public interest and members’ lack of declarative knowledge on topics, while to decline with an increasing portion of online influencers. These findings indicate that anxiety is induced due to a lack of credibility. Also, the amount of conflicting information shared by different people places them in a state of flux. Therefore, a community with more influencers may be more likely to experience anxiety polarization, bringing forth the issue of layered information and inequality.
Assessing the Mental Health of Emerging Adults Through a Mental Health App: Protocol for a Prospective Pilot Study (Preprint)
Authors: Yunusova Asal , Lai Jocelyn , Rivera Alexander P , Hu Sirui , Labbaf Sina , Rahmani Amir M , Dutt Nikil , Jain Ramesh C , Borelli Jessica L
Published: November 2020

BACKGROUND

Individuals can experience different manifestations of the same psychological disorder. This underscores the need for a personalized model approach in the study of psychopathology. Emerging adulthood is a developmental phase wherein individuals are especially vulnerable to psychopathology. Given their exposure to repeated stressors and disruptions in routine, the emerging adult population is worthy of investigation.

OBJECTIVE

In our prospective study, we aim to conduct multimodal assessments to determine the feasibility of an individualized approach for understanding the contextual factors of changes in daily affect, sleep, physiology, and activity. In other words, we aim to use event mining to predict changes in mental health.

METHODS

We expect to have a final sample size of 20 participants. Recruited participants will be monitored for a period of time (ie, between 3 and 12 months). Participants will download the Personicle app on their smartphone to track their activities (eg, home events and cycling). They will also be given wearable sensor devices (ie, devices that monitor sleep, physiology, and physical activity), which are to be worn continuously. Participants will be asked to report on their daily moods and provide open-ended text responses on a weekly basis. Participants will be given a battery of questionnaires every 3 months.

RESULTS

Our study has been approved by an institutional review board. The study is currently in the data collection phase. Due to the COVID-19 pandemic, the study was adjusted to allow for remote data collection and COVID-19–related stress assessments.

CONCLUSIONS

Our study will help advance research on individualized approaches to understanding health and well-being through multimodal systems. Our study will also demonstrate the benefit of using individualized approaches to study interrelations among stress, social relationships, technology, and mental health.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/25775
Méthode sans questions, questions sans méthods
Authors: Jenny Laurent
Published: November 2020

Dans tous ces cas, l’analyse littéraire joue le rôle d’un indispensable garde-fou épistémologique et on voit bien qu’elle est susceptible de s’appliquer à des corpus de discours qui ne sont pas proprement ‘littéraires’. Déléguer aux experts ‘non-littéraires’ la tâche que ces derniers doivent assumer, ce n’est pas seulement réduire la littérature à des contenus, c’est priver les autres sciences humaines du regard critique que les littéraires pourraient porter sur les discours ‘non littéraires’.
Doce, "esto memor"
Authors: Labarthe Patrick
Published: November 2020

Le fonds de culture dont nous sommes les héritiers, il nous appartient de le transmettre à ceux qui viendront après nous, conscients que nos modes de penser, nos réflexes les plus naturels, nos manières d’aimer et de haïr, de combattre autrui ou de le louer, de l’exploiter ou de le servir, dérivent très largement de la culture que les œuvres du passé ont contribué à élaborer. Il y va donc, dans ce devoir de transmission, des racines mêmes de notre identité, de son inachevable conquête.
Sull’"Angeleida" di Erasmo di Valvasone: "divinitas", "humanitas" e "ferinitas" nella guerra angelica
Authors: Franzoni Jessica
Published: November 2020

A coronamento del suo percorso letterario, Erasmo di Valvasone (1528-1593) dà alle stampe un poema sacro sul combattimento degli angeli, l’Angeleida(1590). L’intervento intende concentrarsi sulla descrizione della battaglia tra Michelee Lucifero mostrando la forte analogia che l’autore intende instaurare tradimensione celeste e realtà storico-politiche terrene; in particolare, esso proponealcune ricorrenze, all’interno dell’opera del Valvasone, che a questa doppia natura,divina e umana, rimandano.
Construir el hueco para habitar su borrado: Unas notas sobre la poesía de Josep M. Rodríguez
Authors: Lanz Juan José
Published: November 2020

En este artículo se estudia la poesía de Josep M. Rodríguez como indagaciónen el misterio de lo real, pero también como un modo de ser en la realidad,que condiciona un yo desenfocado, que trata de afi rmarse negándose como actode existencia pero también como acto de lenguaje. La escritura poética no es,entonces, el modo de plasmar la subjetividad, sino la forma de constatar su ausencia;no es un modo de ser, sino de borrarse. Escribir poesía es una invitacióna la comprensión de una realidad fragmentaria.
Entrevista a cinco editores españoles de poesía: Manuel Borrás (Pre-Textos), Jesús García Sánchez (Visor), Jesús Munárriz (Hiperión), Pepo Paz (Bartleby) y Javier Sánchez Menéndez (La Isla de Siltolá)
Authors: López Guil Itzíar , Abril Juan Carlos
Published: November 2020

Cinco representativos editores españoles de poesía –Manuel Borrás, JesúsGarcía Sánchez, Jesús Munárriz, Pepo Paz, Javier Sánchez Menéndez– contestanal cuestionario elaborado por los coordinadores de este número.
Preliminar. El vuelo de Ícaro. (Poetas en el siglo xxi)
Authors: Andújar Almansa José
Published: November 2020

El cuadro Paisaje con la caída de Ícaro de Pieter Brueghel es el punto departida de este ensayo que sirve de soporte a toda una serie de refl exiones sobrela teoría y la práctica poéticas españolas en el siglo xxi.
Variaciones sobre el autorretrato en la poesía última
Authors: Scarano Laura
Published: November 2020

La poesía es el espacio donde el yo sucede. Al articularse en términosespaciales instaura un fl uir también temporal: es un cronotopo; y por ende lo essu sujeto –sujetado a dicho devenir–. Por encima de las variantes gramaticalesque adopte el hablante, en el poema se fragua la subjetividad del poeta, desplazada,diferida, suplementada. El autorretrato exhibe ese proceso de recreaciónfi ccional, atento tanto a la «fi gura» como a su «fondo», el contexto histórico y lasconvenciones literarias. Analizamos varios ejemplos de autorretratos poéticosactuales para ver las tensiones entre el efecto de verosimilitud y la búsqueda dedislocación del modelo. Y en esa trama relacional mostraremos su parentescocon la autopoética como tipo discursivo, para exhibir en primer lugar el perfi lartístico del yo, sus motivaciones y proceso creador.
Thought Line Synopsis for a TV Series Screen Script: ADVANCE
Authors: Achuthan Prof. M. Radh
Published: November 2020

N/a
The 1990 World Summit for Children: An Interview with Landon Pearson
Authors: Griffin Raven , Ham Sarah
Published: November 2020

This interview with the Hon. Landon Pearson was held in the Landon Pearson Resource Centre for the study of Childhood and Children’s Rights on the Carleton University campus. Virginia Caputo, the Director of the Centre, was present, alongside two research assistants, Raven Griffin and Sarah Ham, who formulated a series of questions for Landon Pearson regarding the 1990 World Summit and associated children’s rights initiatives. As a dedicated advocate for children’s rights, Landon Pearson provides a unique perspective on the 1990 World Summit, the UN Declaration on the Rights of the Child, and the Convention on the Rights of the Child as part of a broader look at the past thirty years of the children’s rights. In looking to the past of children’s rights, Landon Pearson shares insights on the inception and context of the World Summit, as well as an outlook on the present and future of youth activism.
SHORT-TERM EFFECT OF WHEY PROTEIN SUPPLEMENTATION ON THE NUTRITIONAL STATUS AND QUALITY OF LIFE OF PATIENTS WAITING FOR LIVER TRANSPLANTATION
Authors: d’Alessandro Michelle , Morais Jéssica , Mizubuti Yani , Silva Thales da , Fernandes Silvia , Mendes Larissa , Correia Maria Isabel , Generoso Simone
Published: November 2020

Background & aims: Chronic liver disease is associated with
malnutrition that negatively impacts a patient’s health-related quality
of life (HRQoL). We evaluated the short-term effect of whey protein
supplementation on the HRQoL and nutritional and functional status of
patients waiting for liver transplantation (LT). Methods: This was a
double-blind randomized clinical trial with patients waiting for LT who
were randomized into two groups: WP (whey protein supplementation) and
the control (casein supplementation). Both groups received 40g (20g in
the morning and 20 g in the evening) for 15 days. Nutritional and
functional status were evaluated. Energy balance (EB) was calculated as
the difference between energy intake (24-hour recall) and total energy
expenditure. The chronic liver disease questionnaire (CLDQ) was used to
assess HRQoL. All measurements were performed before and after the
intervention. Results: Fifty-six patients were evaluated. Malnutrition
was present in 56.9% of patients, and it was directly associated with a
poor HRQoL (p<0.05). No improvement on the nutritional and
functional status was observed, in either group after protein
supplementation. HRQoL improved after WP and casein supplementation,
with no differences between groups (p>0.05). Patients who
met protein requirements and had a positive EB demonstrated a higher
HRQoL score (4.9) (p<0.05), without between-group differences.
Conclusion: Malnutrition substantially reduces HRQoL. Short-term WP or
casein supplementation improved the HRQoL.
Preparing for Audit Data Analytics with the AICPA General Ledger Audit Data Standards
Authors: Lee Lorraine S. , Casterella Gretchen , Wray Barry
Published: November 2020

It is challenging for auditors to effectively and efficiently use data analytics in audit procedures and general ledger testing when the data acquired from clients is often incomplete and not in a usable format. Considerable time must be spent cleansing, transforming, standardizing, and validating the data prior to analyzing it. This problem motivated the AICPA task force to develop a set of Audit Data Standards (ADS) for streamlining the exchange of data. This paper describes an extensive exercise where students: (1) develop a Microsoft Access database that complies with the ADS for general ledger data; (2) cleanse and transform non-standardized client data for import into an ADS-compliant database; and (3) write queries for general ledger testing and journal entry testing. The exercise strengthens students' database and query-writing skills, while introducing the ADS in the context of realistic tasks to support a financial statement audit.
Not So Fuzzy Auditing Analytics
Authors: Hoelscher Jamie L. , Shonhiwa Trevor
Published: November 2020

In light of the increased emphasis on data analytics by accounting practitioners and accreditation bodies, the objective of this paper is to present a case that will help increase students' understanding of textual analytics, which is an under-researched area of data analytics (Fisher 2018). Specifically, students will use both conditional formatting and the fuzzy lookup tool to examine a dataset for possible instances of fictitious vendor fraud, a common and often costly type of fraud. The case takes students through the comprehensive data analytics cycle. First, students are instructed how to test for fictitious vendors by using data analytic techniques. Students will then rely on the underlying data to analyze potential relationships and trends. In the final step, students will communicate results via a memorandum.
Retinol-Binding Protein 4 Activates STRA6 Provoking Pancreatic β Cell Dysfunction in Type 2 Diabetes
Authors: Admin Ada , Huang Rong , Bai Xinxiu , Li Xueyan , Wang Xiaohui , Zhao Lina
Published: November 2020

Pancreatic β cell dysfunction plays a decisive role in
progression of type 2 diabetes. Retinol binding protein 4 (RBP4) is a prominent
adipokine in type 2 diabetes while its effect on β cell function remains
elusive and the underlying mechanisms are unknown. Here, we found that
elevated circulating RBP4 levels were inversely correlated with pancreatic β
cell function in db/db mice across different glycemic stages. RBP4
directly suppressed glucose stimulated insulin secretion (GSIS) in primary
isolated islets and INS-1E cells in a dose- and time-dependent manner.
RBP4-transgenic overexpressing mice (RBP4-Tg) showed a dynamic decrease of GSIS
which appeared as early as 8-week-old preceding the impairment of insulin
sensitivity and glucose tolerance. Islets isolated from RBP4-Tg mice showed a
significant decrease of GSIS. Mechanistically, we demonstrated that the stimulated by
retinoic acid 6(STRA6), RBP4’s only known specific membrane receptor, is
expressed in β cells and mediates the inhibitory effect of RBP4 on insulin
synthesis via JAK2/STAT1/ISL-1 pathway. Moreover, decreasing circulating RBP4
level could effectively restore β cell dysfunction and ameliorate hyperglycemia
in db/db mice. These observations revealed a role of RBP4 in pancreatic β cell
dysfunction which provided new insight into the diabetogenic effect of RBP4.
Factors Affecting Dividend Policy: Empirical Study from Pharmaceutical’s Companies in Pakistan (PSX)
Authors: Gul Sajida , Ullah Irfan , Gul Hina , Rasheed Shahid
Published: November 2020

The existing study intends to measure those factors that affect dividend policy by considering pharmasuitacal’s companies registered on PSX from 2013 to 2017. Population based on all sectors of Pakistan Stock Exchange (PSX) in which pharmaceutical’s companies taken as a sample by using census sampling technique because all companies of pharmaceutical sector were considered. Panel VAR model, fixed effect model (FAM) and also used a regression model to define the influence of IV on DV. The results revealed that has a significant effect of managerial ownership, debt policy, ROA, firm size and free cash flow on dividend policy. The findings of this study demonstrated that the company’s future performance has more concern for the betterment investors than current revenue. There should be active focus on the future aspects in order to improve firm performance.