bluuebunny/crossref_metadata_2025 huggingface dataset:
Meaning mattering in Björk's Biophilia: An analysis from the viewpoint of Karen Barad's agential realism
Authors: Degórski Przemysław
Published: November 2022

The aim of this paper is to analyse Björk's transdisciplinary project Bio-philia in the context of Karen Barad's agential realism. I will compare how matter creates meaning in both the artist's and the researcher's approach from the relationship between phenomena occurring in the physical and 'natural' world. The first part of the article presents the principles of Barad's point of view to a new materialism paradigm and focuses on how matter takes an active role in creating meanings and how it is performatively correlated with an apparatus. This problem also highlights how new materialism approaches an intra-connected relationship between human and non-human beings. By showcasing this perspective I will try to find similarities in Björk's perspective of creating sound in Biophilia. I will analyse the project in terms of relationships between natural phenomena and music theory elements (that Björk connected within the songs), ways of using technology by the Icelandic artist and Biophilia's application as a tool with similar characteristics to Barad's apparatus.
Sexist stereotypes in the Spanish speaking press: A collocational analysis of the lemmas man and woman
Authors: Castro Mosqueda Héctor , Rodríguez Sánchez Ignacio
Published: November 2022

This study investigates the often subtle and at times blatant presence of misogynistic language in our daily lives. This study queried the News on the Web (NOW) corpus to conduct an appraisal of the collocational behavior of the lemmas woman and man. Furthermore, by using network graphs, we expand the analysis of collocations beyond traditional corpus approaches which helped provide lexical evidence of stereotypical constructions. This work also intends to promote the use of techniques and tools from corpus linguistics in the digital humanities. The collocational profile drawn up based on corpus evidence shows that man collocated more strongly with adjectives related to mental sharpness, sexuality, and fertility whereas woman patterned with adjectives related to health, marital status, and religious affiliations.
The influence of Surface Cavitation on Hydrodynamic Forces
Authors: Shen Young , Dimotakis Paul
Published: November 2022

A cambered two-dimensional NACA 66 (MOD) wing section was tested in a high speed water tunnel. Two types of cavitation, leading edge sheet and midchord transient streak cavitation, were investigated. Lift, drag and pressure coefficients were measured concurrently with cavitation observations. A method for measuring surface pressure in transient cavities was successfully developed and is discussed in the text. In a partial cavity flow the pressure coefficients measured in the wetted region of the foil away from outside the cavity were found to coincide with the pressure measurements in a fully wetted flow condition. A significant increase in lift with increasing cavity length was measured. However, the lift started to fall off when the cavity length reached about 83 percent of the chord. The occurrence of midchord transient cavities was accompanied by a significant drop in lift and an increase in drag. The influence of surface cavitation on the two dimensional foil force was found to exhibit a strong similarity to propeller thrust breakdown and thrust enhancement as measured by Emerson and Sinclair.
Performance Assessment of Propeller Boss Cap Fin Type Device
Authors: Gearhart Y. , McBride M.
Published: November 2022

Recently published information describes an arrangement consisting of a small set of vanes attached to the rotating hub of the propeller. These vanes are located aft of the propeller and rotate with the propeller. The small vanes are designed to reduce the swirl placed in the slipstream by the action of the propeller. It is reported that the strength of the hub vortex is reduced with this arrangement. The result provides a propeller of higher efficiency. This efficiency gain has been recorded with a relatively large number of ships fitted with this device. The enclosed presents data and analysis evaluating the validity of the claims.
PERCEPCIÓN DE LOS MUSICOTERAPEUTAS PROFESIONALES SOBRE EL TRABAJO DE LAS EMOCIONES EN LA MUSICOTERAPIA DE IMPROVISACIÓN
Authors: Pérez Eizaguirre Miren , Tizón Díaz Manuel
Published: November 2022

El estudio de las emociones y la música ha sido de gran importancia ya que como todos sabemos la música emociona. Sin embargo, se han recorrido diferentes caminos encontrando que en la música existen ciertos elementos que gozan de universalidad en cuanto a emociones se refiere. Para los mu- sicoterapeutas profesionales estas investigaciones pueden ser de gran utilidad en su formación a la hora de llevar a cabo las sesiones a través de la musicoterapia de improvisación. En este estudio se intenta analizar si esto es una realidad y si existe una conciencia a la hora de trabajar las emociones, en cuanto al impacto que tienen los parámetros de la música sobre estas. Para ello, 50 musicotera- peutas profesionales rellenaron un cuestionario con diferentes preguntas sobre la realización de sus sesiones a través de la musicoterapia de improvisación. Los resultados arrojan que es necesaria mayor formación en este campo para poder afianzar a través del entrenamiento musical su práctica real.
UNA PROPUESTA ALTERNATIVA DE EVALUACIÓN EN EL DISEÑO DE LAS INTERACCIONES E INTERFACES TECNOLÓGICAS MUSICALES: EN LA BÚSQUEDA DE NUEVOS PARADIGMAS
Authors: Casillas-Martín Sonia , Vallejo, César Pascual , Cabezas-González Marcos
Published: November 2022

Actualmente el paradigma tecnosimbólico-positivista de la cuarta revolución industrial hipernormaliza nuestras diversas formas de creatividad. Su estandarización y automatización afectan a ciencia, educa- ción y salud a través del uso y la apropiación de la tecnología. La crisis sanitaria actual ha evidenciado aún más la necesidad de encontrar diseños cognitivos tecnológicos flexibles y resilientes. Gran canti- dad de literatura científica expone las intensas demandas cognitivas involucradas en el ejercicio de la música. Sus hallazgos revelan que la educación musical y la terapia musical son capaces de aportar alternativas a la psicología comportamental o al objetivismo radical, revolucionando el campo de la interacciones tecnológicas en favor de la salud y el bienestar. Teniendo en cuenta esta realidad cien- tífica, este artículo presenta una propuesta de evaluación alternativa construida a partir del método IMTAP (The individualized Music Therapy Assessmente Profile), afrontando así la actual necesidad de explorar enfoques creativos de evaluación en el diseño de la tecnología cognitiva, creativa y expresiva, proponiendo la integración proactiva de musicoterapeutas y arteterapeutas profesionales dentro de los equipos que diseñan las interacciones e interfaces tecnológicas creativas y expresivas, en la búsqueda de una posible alternativa evaluativa respetuosa con la educación, salud y el bienestar.
Handling Complexity in Modern Software Engineering: Editorial Introduction to Issue 32 of CSIMQ
Authors: Zimmermann Alfred , Marcinkowski Bartosz
Published: November 2022

The potential of the Internet and related digital technologies, such as the Internet of Things (IoT), cognition and artificial intelligence, data analytics, services computing, cloud computing, mobile systems, collaboration networks, and cyber-physical systems, are both strategic drivers and enablers of modern digital platforms with fast-evolving ecosystems of intelligent services for digital products. This issue of CSIMQ presents three recent articles on modern software engineering. First, we focus on continuous software development and place it in the context of software architectures and digital transformation. The first contribution is followed by the description of the basis of specific security requirements and adequate digital monitoring mechanisms. Finally, we present a practical example of the digital management of livestock farming.
Contextualising Curriculum for a Multi-Course Classroom: A Case Study
Authors: Kelly Kate
Published: November 2022

Integrated curriculum encourages diverse cohorts of students to engage in relevant and meaningful activities that can be connected to their interests both in and beyond the classroom. This research investigated whether contextualising the content and learning activities to specific cohorts, while retaining the same assessments and learning outcomes, would be effective in increasing student engagement and overall grades. The findings indicated that when content was contextualised engagement and performance significantly improved. This finding holds true for both face to face delivery and remote delivery, indicating that the contextualisation of content has greater impact on student outcomes than mode of delivery.
Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans
Authors: Kim Jun , Jimenez David S , Ragipani Bhavana , Zhang Bo , Street Lena A , Kramer Maxwell , Albritton Sarah E , Winterkorn Lara H , Morao Ana K , Ercan Sevinc
Published: November 2022

Condensins are molecular motors that compact DNA via linear translocation. In Caenorhabditis elegans, the X-chromosome harbors a specialized condensin that participates in dosage compensation (DC). Condensin DC is recruited to and spreads from a small number of recruitment elements on the X-chromosome (rex) and is required for the formation of topologically associating domains (TADs). We take advantage of autosomes that are largely devoid of condensin DC and TADs to address how rex sites and condensin DC give rise to the formation of TADs. When an autosome and X-chromosome are physically fused, despite the spreading of condensin DC into the autosome, no TAD was created. Insertion of a strong rex on the X-chromosome results in the TAD boundary formation regardless of sequence orientation. When the same rex is inserted on an autosome, despite condensin DC recruitment, there was no spreading or features of a TAD. On the other hand, when a ‘super rex’ composed of six rex sites or three separate rex sites are inserted on an autosome, recruitment and spreading of condensin DC led to the formation of TADs. Therefore, recruitment to and spreading from rex sites are necessary and sufficient for recapitulating loop-anchored TADs observed on the X-chromosome. Together our data suggest a model in which rex sites are both loading sites and bidirectional barriers for condensin DC, a one-sided loop-extruder with movable inactive anchor.
Sampling motion trajectories during hippocampal theta sequences
Authors: Ujfalussy Balazs B , Orbán Gergő
Published: November 2022

Efficient planning in complex environments requires that uncertainty associated with current inferences and possible consequences of forthcoming actions is represented. Representation of uncertainty has been established in sensory systems during simple perceptual decision making tasks but it remains unclear if complex cognitive computations such as planning and navigation are also supported by probabilistic neural representations. Here, we capitalized on gradually changing uncertainty along planned motion trajectories during hippocampal theta sequences to capture signatures of uncertainty representation in population responses. In contrast with prominent theories, we found no evidence of encoding parameters of probability distributions in the momentary population activity recorded in an open-field navigation task in rats. Instead, uncertainty was encoded sequentially by sampling motion trajectories randomly and efficiently in subsequent theta cycles from the distribution of potential trajectories. Our analysis is the first to demonstrate that the hippocampus is well equipped to contribute to optimal planning by representing uncertainty.
High-resolution secretory timeline from vesicle formation at the Golgi to fusion at the plasma membrane in S. cerevisiae
Authors: Gingras Robert M , Sulpizio Abigail M , Park Joelle , Bretscher Anthony
Published: November 2022

Most of the components in the yeast secretory pathway have been studied, yet a high-resolution temporal timeline of their participation is lacking. Here, we define the order of acquisition, lifetime, and release of critical components involved in late secretion from the Golgi to the plasma membrane. Of particular interest is the timing of the many reported effectors of the secretory vesicle Rab protein Sec4, including the myosin-V Myo2, the exocyst complex, the lgl homolog Sro7, and the small yeast-specific protein Mso1. At the trans-Golgi network (TGN) Sec4’s GEF, Sec2, is recruited to Ypt31-positive compartments, quickly followed by Sec4 and Myo2 and vesicle formation. While transported to the bud tip, the entire exocyst complex, including Sec3, is assembled on to the vesicle. Before fusion, vesicles tether for 5 s, during which the vesicle retains the exocyst complex and stimulates lateral recruitment of Rho3 on the plasma membrane. Sec2 and Myo2 are rapidly lost, followed by recruitment of cytosolic Sro7, and finally the SM protein Sec1, which appears for just 2 s prior to fusion. Perturbation experiments reveal an ordered and robust series of events during tethering that provide insights into the function of Sec4 and effector exchange.
Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex
Authors: Kasuya Go , Nakajo Koichi
Published: November 2022

Tetrameric voltage-gated K+ channels have four identical voltage sensor domains, and they regulate channel gating. KCNQ1 (Kv7.1) is a voltage-gated K+ channel, and its auxiliary subunit KCNE proteins dramatically regulate its gating. For example, KCNE3 makes KCNQ1 a constitutively open channel at physiological voltages by affecting the voltage sensor movement. However, how KCNE proteins regulate the voltage sensor domain is largely unknown. In this study, by utilizing the KCNQ1-KCNE3-calmodulin complex structure, we thoroughly surveyed amino acid residues on KCNE3 and the S1 segment of the KCNQ1 voltage sensor facing each other. By changing the side-chain bulkiness of these interacting amino acid residues (volume scanning), we found that the distance between the S1 segment and KCNE3 is elaborately optimized to achieve the constitutive activity. In addition, we identified two pairs of KCNQ1 and KCNE3 mutants that partially restored constitutive activity by co-expression. Our work suggests that tight binding of the S1 segment and KCNE3 is crucial for controlling the voltage sensor domains.
Ecological roles of secondary metabolites of Saposhnikovia divaricata in adaptation to drought stress
Authors: Cao Sisi , Shi Lei , Shen Ying , He Luwen , Meng Xiangcai
Published: November 2022

Saposhnikovia divaricata is a traditional Chinese herb that mainly grows in arid grasslands and strongly adapts to various stresses. Drought is not only a major abiotic stress factor but also a typical feature conducive to producing high-quality medicinal material. The present study investigated by treating S. divaricata plants with polyethylene glycol (PEG-6000). Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) identified 146 compounds from the roots of S. divaricata, among which seven primary metabolites and 28 secondary metabolites showed significant changes after drought treatment. UV-Vis spectrophotometer detected the activity of antioxidant enzymes and the content of superoxide anion (O2−.) and malondialdehyde (MDA). The differential primary metabolites revealed that drought promotes glycolysis, reducing primary metabolism and enhancing secondary metabolism. Meanwhile, the differential secondary metabolites showed an increase in the content of compounds upstream of the secondary metabolic pathway, and other glycosides and increased that of the corresponding aglycones. The activities of antioxidant enzymes and the content of O2−. and MDA shown different changes duing the drought treatment. These observations indicate that drought promotes the biosynthesis and transformation of the secondary metabolites and activity of antioxidant enzymes, improving plant adaptability. The present study also analyzed a few primary and secondary metabolites of S. divaricata under different degrees and durations of drought and speculated on the metabolic pathways in an arid environment. The findings indicate the biological nature, diversity, and complexity of secondary metabolites and the mechanisms of plant adaptation to ecological stress.
Imagined and extended contact experiences and adolescent bystanders' behavioral intentions in homophobic bullying episodes
Authors: António Raquel , Guerra Rita , Cameron Lindsey , Moleiro Carla
Published: November 2022

Bystanders' helping interventions in bias‐based bullying are rare, although they have the potential to intervene on behalf of the victim and quickly stop the aggression. Two studies tested, experimentally, the impact of adolescents' imagined (Study 1, N = 113, Mage = 16.17) and extended contact experiences (Study 2, N = 174, Mage = 15.79) on assertive bystanders' behavioral intentions in the context of homophobic bullying, an under‐researched but highly detrimental behavior that emerges mainly during early adolescence. Potential mediators (empathic concern, social contagion concerns, and masculinity/femininity threat) were also examined. Results showed that female younger participants revealed more behavioral intentions to help victims of homophobic bullying when asked to imagine an interaction with an outgroup member (Study 1). Younger participants revealed less masculinity/femininity threat in the positive extended contact condition, and female participants revealed less empathic concern in the negative extended contact condition (Study 2). Overall, these findings identify specific conditions (e.g., younger females) where indirect contact interventions (i.e., extended and imagined) are likely to have a stronger impact. Age and sex differences were found to illustrate how adolescents vary in their behavioral intentions, empathic concern, and threat; and also highlight the need to further examine age and sex differences regarding responses to homophobic bullying episodes.
Highly Conductive Nitrogen‐Doped sp2/sp3 Hybrid Carbon as a Conductor‐Free Charge Storage Host
Authors: Wang Qi , Su Jincang , Chen Hailun , Wang Deqiang , Tian Xiaoyu , Zhang Yujian , Feng Xin , Wang Shun , Li Jun , Jin Huile
Published: November 2022

It is commonly accepted that the increased degree of graphitization leads to a higher electrical conductivity of carbon materials. However, more and more evidence reveals that heteroatom doping on carbon host can also improve the conductivity, owing to the dopant atoms contributing to higher charge delocalization and density of donor states near Fermi level. The reality is, such conductivity improvement from doping is often overwhelmed by graphitized carbon. Although heteroatom‐doped carbon is widely used as active materials in the fields of energy storage and electrocatalysis, which still requires extra carbon‐based conductive additives to enhance the overall conductivity. In this stu, it is demonstrated that the electrical conductivity of finely designed nitrogen‐doped carbon is even beyond the commercialized carbon conductors over 3.5 times, endowing such conductive agent‐free electrode material an excellent performance in an all‐solid‐state flexible supercapacitor. The theoretical simulation further demonstrates that N‐doped sp2/sp3 hybrid carbon can migrate the Fermi level to the conduction band, leading to an n‐type conductivity due to the additional electrons caused by the N dopant.
Ultrasensitive Perovskite Photodetector for Filter‐Free Color Single‐Pixel Imaging
Authors: Zhang Zhihong , Zheng Peixia , Yan Shan‐Shan , Qiao Bao‐Shi , Ng Kar Wei , Liu Hong‐Chao , Wang Shuang‐Peng , Wei Zhipeng
Published: November 2022

Filter‐free color imaging is the long‐pursued solution for its simple structure, low cost, and high stability. However, a spectroscopic unit is still necessary for the current Si‐based imaging unit due to the intrinsic photoresponse properties of Si. Here, the authors demonstrate a filter‐free color‐resolved single‐pixel imaging (SPI) by combining the working mechanism of computational ghost imaging and the response characteristic of perovskite. Benefitting from a broad linear dynamic range (106.5 dB) and a high detectivity (4.03 × 1014 Jones) of the fabricated ultrasensitive MAPbBr3 microwire arrays (MWAs) photodetector, the light attenuation caused by an object can be effectively correlated with its color. The reconstructed images of both transmissive and reflective color objects show a high wavelength resolution reaching 20 nm in the range of 400–540 nm, which is impossible to achieve by commercial silicon‐photodiode‐based ones. This work can open a new door for the image acquisition of color‐sensitive objects and also pave a way for the evolution of the next generation of detectors and cameras with low‐dimensional perovskite materials.
Neocortical Lewy Body Pathology Parallels Parkinson's Dementia, but Not Always
Authors: Martin W. R. Wayne , Younce John R. , Campbell Meghan C. , Racette Brad A. , Norris Scott A. , Ushe Mwiza , Criswell Susan , Davis Albert A. , Alfradique‐Dunham Isabel , Maiti Baijayanta , Cairns Nigel J. , Perrin Richard J. , Kotzbauer Paul T. , Perlmutter Joel S.
Published: November 2022

Objective

The objective of this study was to evaluate the relationship between Parkinson's disease (PD) with dementia and cortical proteinopathies in a large population of pathologically confirmed patients with PD.

Methods

We reviewed clinical data from all patients with autopsy data seen in the Movement Disorders Center at Washington University, St. Louis, between 1996 and 2019. All patients with a diagnosis of PD based on neuropathology were included. We used logistic regression and multivariate analysis of covariance (MANCOVA) to investigate the relationship between neuropathology and dementia.

Results

A total of 165 patients with PD met inclusion criteria. Among these, 128 had clinical dementia. Those with dementia had greater mean ages of motor onset and death but equivalent mean disease duration. The delay between motor symptom onset and dementia was 1 year or less in 14 individuals, meeting research diagnostic criteria for possible or probable dementia with Lewy bodies (DLB). Braak Lewy body stage was associated with diagnosis of dementia, whereas severities of Alzheimer's disease neuropathologic change (ADNC) and small vessel pathology did not. Pathology of individuals diagnosed with DLB did not differ significantly from that of other patients with PD with dementia. Six percent of individuals with PD and dementia did not have neocortical Lewy bodies; and 68% of the individuals with PD but without dementia did have neocortical Lewy bodies.

Interpretation

Neocortical Lewy bodies almost always accompany dementia in PD; however, they also appear in most PD patients without dementia. In some cases, dementia may occur in patients with PD without neocortical Lewy bodies, ADNC, or small vessel disease. Thus, other factors not directly related to these classic neuropathologic features may contribute to PD dementia. ANN NEUROL 2023;93:184–195
Fluor‐Dirigierte Automatisierte Mannosid Assemblierung
Authors: Teschers Charlotte S. , Gilmour Ryan
Published: November 2022

Die automatisierte Glykan Assemblierung (AGA) auf festen Trägern ist heutzutage von unschätzbarem Wert, um die biologische Bedeutung komplexer Kohlenhydrate mit den anhaltenden Herausforderungen ihrer Synthese in Einklang zu bringen. Während AGA‐Plattformen die Konstruktion vieler natürlicher Zucker verändert haben, steckt die Validierung der Konstruktion wohldefinierter (positionsselektiv modifizierter) Glykomimetika noch in den Kinderschuhen. Motiviert durch die Bedeutung der Fluorierung in der Arzneimittelforschung, der biomedizinischen Bedeutung von 2‐Fluorzuckern und den bemerkenswerten Selektivitäten der fluorgesteuerten Glykosylierung, wird die Fluor‐dirigierte automatisierte Glykan Assemblierung (FDAGA) entwickelt. Diese Strategie nutzt das Fluoratom für die stereokontrollierte Glykosylierung auf einem festen Träger, wodurch die Abhängigkeit von O‐basierten dirigierenden Gruppen entfällt. Das logische Design von C2‐fluorierten Mannose‐Bausteinen und ihre Anwendung in der vollständig (α‐)stereoelektiven automatisierten Assemblierung von linearen und verzweigten fluorierten Oligomannosiden wird beschrieben. Diese Strategie kann in bestehende AGA‐ und Post‐AGA‐Protokolle integriert werden, um den Anwendungsbereich der programmierten Kohlenhydratsynthese zu erweitern.
Comprehensive investigation on physical and chemical properties of γ‐irradiated multilayer PE/EVOH/PE film: A multiscale approach
Authors: Gaston Fanny , Dupuy Nathalie , Girard‐Perier Nina , Marque Sylvain R. A. , Dorey Samuel
Published: November 2022

The study evaluates findings on the impact of γ‐irradiation on the single‐use, multilayer plastic film that is manufactured for the biotechnological and biopharmaceutical environments. It is comprised of a multilayer film that offers durability and gas (O2, CO2 and H2O) shielding properties. Polyethylene (PE) and ethylene vinyl alcohol (EVOH) are the parts within this film, which as a whole, is PE/EVOH/PE. The impact of γ‐irradiation on the nonirradiated and γ‐irradiated (from 30 kGy up to 270 kGy) PE multilayer film is investigated by colorimetry measurement, Fourier transform infrared and Raman spectroscopies, pH measurement, ion chromatography and conductivity measurement, tensile tests, X‐ray photoelectron spectroscopy, differential scanning, and oxygen and water vapor transmission rate. AComDim and Principal Components Analysis are two chemometric tools that are utilized to understand both physical and chemical changes, along with the main factors contributing to polymer degradation in the PE multilayer film while under γ‐irradiation.
Left ventricular pseudoaneurysm secondary to recurrent mitral prosthetic valve endocarditis
Authors: Nishiori Hironobu , Matsumiya Goro
Published: November 2022

An 86‐year‐old man who had undergone two mitral valve replacements developed heart failure due to prosthetic valve infection and left ventricular pseudoaneurysm (LVPA). LVPA due to infective endocarditis is rare and caused by the abscess formation in the left ventricular myocardium. Infective endocarditis caused by enterococci requires attention to relapse.
Vibrational Circular Dichroism Unravels Supramolecular Chirality and Hydration Polymorphism of Nucleoside Crystals
Authors: Krupová Monika , Leszczenko Patrycja , Sierka Ewa , Emma Hamplová Sára , Pelc Radek , Andrushchenko Valery
Published: November 2022

Invited for the cover of this issue are Valery Andrushchenko, Monika Krupová, and co‐workers at the Institute of Organic Chemistry and Biochemistry (IOCB Prague) of the Czech Academy of Sciences. The image depicts a “crystal city” illuminated by “chiral suns” shining left‐ and right‐circularly polarized light (L‐CPL and R‐CPL), which reveals differences in the structure of the chiral crystalline “skyscrapers”. Designed by Tomáš Belloň @ IOCB Prague. Read the full text of the article at 10.1002/chem.202201922.
Smart Phototheranostics based on Carbon Nanohorns for Precise Imaging‐Guided Post‐PDT toward Residual Tumor Cells after Initial Phototherapy
Authors: Zhang Hengming , Zhu Chengyuan , Liang Jiawei , Li Shuzhen , Hu Lan‐Fang , Liang Hong , Kuo Wen‐Shuo , Shen Xing‐Can
Published: November 2022

As promising photonic material, phototheranostics can be activated in the laser irradiation range of tumor with sensitivity and spatiotemporal precision. However, it is difficult to completely eradicate solid tumors due to their irregularity and limited laser irradiation area. Herein, multi‐stimulus responsive HA−Ce6@SWNHs were constructed with single‐walled carbon nanohorns (SWNHs) and chlorine e6 (Ce6) modified hyaluronic acid (HA) via non‐covalent binding. This SWNHs‐based phototheranostics not only exhibited water dispersion but also could target tumor and be activated by near‐infrared light for photodynamic therapy (PDT) and photothermal therapy (PTT). Additionally, HA−Ce6@SWNHs could be degraded by hyaluronidase in residual tumor cells, causing HA−Ce6 to fall off the SWNHs surfaces to restore autofluorescence, thus precisely guiding the programmed photodynamic treatments for residual tumor cells after the initial phototherapy. Thus, this work provides a rationally designed multiple‐stimulus‐response strategy to develop smart SWNHs‐based phototheranostics for precise PDT/PTT and post‐treatment imaging‐guided PDT of residual tumor cells.
Luminescent Crystalline Carbon‐ and Nitrogen‐Centered Organic Radicals Based on N‐Heterocyclic Carbene‐Triphenylamine Hybrids
Authors: Li Xin , Wang Yi‐Lin , Chen Can , Han Ying‐Feng
Published: November 2022

Developing luminescent radicals with tunable emission is a challenging task due to the limitation of alternative skeletons. Herein, a series of carbene‐triphenylamine hybrids were prepared by the direct C2‐arylation of N‐heterocyclic carbenes with 4‐bromo‐N,N‐bis(4‐methoxyphenyl)aniline. These hybrids showed multiple redox‐active properties and could be converted to carbon‐centered luminescent radicals with blue‐to‐cyan emissions (λmax: 436–486 nm) or nitrogen‐centered luminescent radicals with orange emissions (λmax: 590–623 nm) through chemical reduction or oxidation, respectively. The radical species were characterized by electron paramagnetic resonance spectroscopy, ultraviolet‐visible spectroscopy, and single‐crystal X‐ray diffractometry analysis. Notably, the corresponding nitrogen‐centered radicals exhibited good stability in atmospheric air, and their thermal decomposition temperatures were determined to be above 200 °C. In addition, spectral and theoretical calculations indicate that all radicals exhibit anti‐Kasha emissions.
Edge‐driven ubiquitous wireless communication for robust cluster intelligent piano presentation platform considering system security
Authors: Wang Qi
Published: November 2022

With the popularization of 6G‐driven wireless access networks and the development of edge computing, the connection between piano performance and artificial intelligence algorithms is getting closer and closer. 6G was first used to solve large‐capacity, short‐latency communication problems, and research results in this field abound. However, in practical applications, the deployment of 6G high‐frequency network is a major problem faced by the industry. This paper mainly studies the artificial robust cluster piano demonstration platform from the perspective of the fusion of 6G and edge computing. We firstly consider that the edge computing is a technology in which artificial intelligence algorithms are transplanted to edge devices and chips. The vision of the 6G network is to realize ubiquitous wireless intelligence, which includes three dimensions: mobile ultra‐broadband, super Internet of Things, and artificial intelligence, and realizes the conversion of piano scores into digital signals. Artificial Robust Clustering is a comprehensive technique that incorporates many disciplines, including phonetics, artificial intelligence, computer science, and more. This paper analyzes the fusion technology of 6G and edge computing and studies the robust cluster intelligent piano demonstration platform. The mentioned technologies are combined together to make the designed efficient.
Myoepithelial carcinoma of the parotid gland with a novel CTCF::NCOA2 fusion
Authors: Gandhi Jatin , Mantilla Jose G. , Ricciotti Robert W. , Chen Eleanor Y. , Liu Yajuan J. , Bandhlish Anshu
Published: November 2022

We describe a case of a myoepithelial carcinoma of the superficial parotid gland in a 46‐year‐old male harboring a novel CTCF::NCOA2 gene fusion. To our knowledge, this novel gene fusion has not been described previously in myoepithelial carcinoma. A 46‐year‐old male patient presented with a mass involving the superficial left parotid gland with extension into the external auditory canal (EAC) and erosion of the conchal cartilage. Histologically, the neoplasm was composed of uniform spindled, epithelioid/ovoid cells arranged in cords and nests within hyalinized to myxoid stroma. On immunohistochemistry (IHC), the tumor cells demonstrated patchy and variable staining for low molecular weight cytokeratin (CAM5.2), pan‐cytokeratin (OSCAR), and S‐100. Overall, the morphological and immunohistochemical attributes supported a locally aggressive tumor of myoepithelial differentiation consistent with myoepithelial carcinoma. Molecular analysis using a custom 115‐gene gene panel by targeted RNA sequencing, showed an in‐frame CTCF::NCOA2 fusion. In addition to reporting this novel fusion in myoepithelial carcinoma, we also discuss relevant differential diagnosis, and provide a brief review of NCOA2 gene function in both normal and neoplastic contexts.
Palaeomagnetic constraints on a Late Permian to Early Triassic final closure of thePalaeo‐AsianOcean
Authors: Zhang Donghai , Zhao Guochun , Huang Baochun , Zhao Jie , Zhao Qian
Published: November 2022

Final closure of the Palaeo‐Asian Ocean signifies the ultimate amalgamation of the North China, Tarim, Mongolia, Songliao, Xilinhot and other Central Asian blocks, and therefore, is critical in reconstructing the configuration of the Pangea supercontinent during the late Palaeozoic to early Mesozoic. However, the final closure time remains contentious. Here, we present a systematic palaeomagnetic study on the Upper Permian sedimentary sequences of the Xilinhot Block, located to the north of the Solonker Suture Zone. Rock magnetic results indicate stable pseudo‐domain magnetite is the dominant magnetic carrier. The characteristic components isolated between ~350 and 590°C display the existence of dual polarities. Combined with previous results, the merged site‐mean directions yield a negative reversal test and inconclusive fold tests. By comparing with coeval and posterior data, and correlating with stitching plutons that intruded the sampling sections, we argue for a remagnetization origin for the newly obtained data, which is most likely acquired during the thermal event when the stitching granitic plutons intruded at 242.0 ± 3.7 Ma. Then we synthesized available palaeomagnetic data from the Central Asian Orogenic Belt and adjacent blocks, and propose a Late Permian to Early Triassic final closure of the Palaeo‐Asian Ocean. Our reconstruction of Pangea in the Early Triassic negates the existence of a cut‐through seaway between the Mongol‐Okhotsk and Palaeo‐Asian Oceans. The Mongol‐Okhotsk Ocean was an extension of Panthalassa, in trumpet‐shaped and faced to the east, rather than an individual oceanic basin separating Siberia from the Cinamuria Block.
Trinodal Self‐Penetrating Versus cds 3‐Dimensional Networks Using Bis(3,2’ : 6’,3’’‐terpyridine) Building Blocks: the Solvent Makes the Difference
Authors: Capomolla Simona S. , Manfroni Giacomo , Prescimone Alessandro , Constable Edwin C. , Housecroft Catherine E.
Published: November 2022

Reactions between Co(NCS)2 and 24,24‐[2,5‐bis(cyclohexyloxy)‐1,4‐phenylene]di(13,22 : 26,33‐terpyridine) (1), 24,24‐[2,5‐bis(cyclohexylmethoxy)‐1,4‐phenylene]di(13,22 : 26,33‐terpyridine) (2), and 24,24‐[2,5‐bis(2‐phenylethoxy)‐1,4‐phenylene]di(13,22 : 26,33‐terpyridine) (3) under conditions of crystal growth by layering at room temperature lead to 3‐dimensional nets with either a cds or trinodal self‐penetrating topology depending upon the solvents (MeOH/C6H5Cl, MeOH/1,2‐Cl2C6H5, or MeOH/CHCl3) used in the crystallization experiments. The cds network was found for [Co(NCS)2(1)]n⋅2nC6H4Cl2, [Co(NCS)2(2)]n⋅4nC6H4Cl2, and [Co(NCS)2(3)]n⋅2.5nC6H5Cl, while a trinodal self‐penetrating net was observed in [Co2(NCS)4(2)2]n⋅5.5nCHCl3⋅0.2nMeOH. Preliminary structural data for single crystals from the reactions of Co(NCS)2 and 1 or Co(NCS)2 and 3 from MeOH/CHCl3 solvent combinations also evidenced the assemblies of trinodal self‐penetrating nets. Both net topologies assemble from a combination of planar, 4‐connecting metal and ligand nodes. The role of the solvent in directing the network type is investigated.
Development from a distance: Exploring an international non‐profit's interactions with communities during the COVID‐19 pandemic
Authors: Peiffer Ashley , Harte Michael
Published: November 2022

A case study analysis of an international development non‐profit identifies strategies and decision‐making processes utilized to engage community members in person and virtually during the first year of the COVID‐19 pandemic. The strategies employed led to a continuation of projects in the field, potentially excluding some stakeholder groups from decision‐making processes at the community level. Staff members described how power dynamics and geographic distance affected internal decision‐making for community involvement, highlighting the importance of adopting a critical self‐reflection approach to facilitate communication among an intercultural team for more equitable community engagement.
Bovine lactoferrin inhibits SARS‐CoV‐2 and SARS‐CoV‐1 by targeting the RdRp complex and alleviates viral infection in the hamster model
Authors: He Shi‐ting , Qin Hongbo , Guan Lin , Liu Ke , Hong Bixia , Zhang Xiaoxu , Lou Fuxing , Li Maochen , Lin Wei , Chen Yangzhen , He Chengzhi , Liu Feitong , Lu Shanshan , Luo Shengdong , Zhu Shaozhou , An Xiaoping , Song Lihua , Fan Huahao , Tong Yigang
Published: November 2022

Breast milk has been found to inhibit coronavirus infection, while the key components and mechanisms are unknown. We aimed to determine the components that contribute to the antiviral effects of breastmilk and explore their potential mechanism. Lactoferrin (Lf) and milk fat globule membrane inhibit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐related coronavirus GX_P2V and transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like particles in vitro and block viral entry into cells. We confirmed that bovine Lf (bLf) blocked the binding between human angiotensin‐converting enzyme 2 and SARS‐CoV‐2 spike protein by combining receptor‐binding domain (RBD). Importantly, bLf inhibited RNA‐dependent RNA polymerase (RdRp) activity of both SARS‐CoV‐2 and SARS‐CoV in vitro in the nanomolar range. So far, no biological macromolecules have been reported to inhibit coronavirus RdRp. Our result indicated that bLf plays a major role in inhibiting viral replication. bLf treatment reduced viral load in lungs and tracheae and alleviated pathological damage. Our study provides evidence that bLf prevents SARS‐CoV‐2 infection by combining SARS‐CoV‐2 spike protein RBD and inhibiting coronaviruses' RdRp activity, and may be a promising candidate for the treatment of coronavirus disease 2019.
Identification of tropical cyclone centre based on satellite images via deep learning techniques
Authors: Long Teng , Fu Jiyang , Tong Biao , Chan Pakwai , He Yuncheng
Published: November 2022

A tropical cyclone (TC) is a highly destructive natural disaster. Accurate identification of key parameters of TCs is prerequisite for most TC‐related research and practices. The centre position is one of TC's basic parameters. However, comparison of TC best track data released by different meteorological institutes usually indicates a noticeable discrepancy for this parameter among varied data sources. In this study, efforts are made towards identifying the centre location of TCs via deep learning techniques, based on TC satellite cloud images (SCIs). Six deep learning models are analysed and compared. YOLOv4 model achieved a confidence of 99.84%, which is better than other models. In addition, we further explore the factors affecting the positioning accuracy of the YOLOv4 model and its application to the location identification of multiple TCs and the tracking of individual TCs. Results demonstrate that the YOLOv4 model has a probability exceeding 99% for identifying multiple TC locations and also performs well for single TC tracking.
On some K3 surfaces with order sixteen automorphism
Authors: Comparin Paola , Priddis Nathan , Sarti Alessandra
Published: November 2022

We consider K3 surfaces of Picard rank 14 which admit a purely non‐symplectic automorphism of order 16. The automorphism acts on the second cohomology group with integer coefficients and we compute the invariant sublattice for the action. We show that all of these K3 surfaces admit an elliptic fibration and we compute the invariant lattices in a geometric way by using special curves of the elliptic fibration. The computation of these lattices plays an important role when one wants to study moduli spaces and mirror symmetry for lattice polarized K3 surfaces.
Evaluation of adsorbent materials for carbon dioxide capture
Authors: Shamiri A. , Shafeeyan M. S.
Published: November 2022

Global warming has in recent years become a cause for serious concern. It is believed to result from the release of greenhouse gases into the atmosphere, particularly carbon dioxide. Upon assessing the recent developments, it can be learnt that attempts in relation to the reduction of anthropogenic carbon dioxide content and decreasing the emission of greenhouse gases appear to be among the key issues. Despite a range of technologies and approaches established over the years, the issue of separating carbon dioxide from gas streams still cannot be addressed. Notwithstanding having developed new methods, another substantial challenge identified in the area is the growth of adsorbents with relatively higher performance. It is worthy of note that they help balance an array of optimization‐needed factors which include efficiency, engineering feasibility and costs. Zeolites, metal‐organic frameworks, silica and activated carbon are among the adsorption materials which are widely discussed in the literature. Accordingly, recent studies focusing on such materials are comprehensively discussed and summarized in this review. Besides, the cost, carbon capture capacity and selectivity which are among the major concerns with respect to selecting adsorbents are compared in this paper. Furthermore, both the privileges and drawbacks of each type of adsorbent are presented in this manuscript. Despite the encouraging results achieved in this study, developing more effective adsorbents to capture carbon dioxide remains a fundamental challenge. Therefore, further innovations regarding the design and synthesis of adsorbents are essential for future applications.
Analysis and prediction of erosion behavior of short kenaf fiber‐based hybrid composites using response surface method integrated with neural networks
Authors: Nayak S.K. , Satapathy A.
Published: November 2022

There has been a huge demand in industries for the design and development of bio‐degradable and low‐cost wear resistant composite materials since long. In response to this, the present work includes an exhaustive analysis for the solid particle erosion characteristics of a new class of hybrid polyester composites reinforced with a natural fiber (kenaf) and filled with a construction waste (marble dust) in different proportions. The test trials on the composite samples are conducted using a DUCOM high temperature erosion test rig as per ASTM G76. The experimentation and analysis are conducted as per the L30 model of response surface method (RSM). The results revealed that the incorporation of marble dust enhanced the resistance to erosion wear of the fiber‐polyester composites and among the control factors, the contributions of striking velocity and angle of impingement towards the erosion rate are significant. A predictive model working on the concept of neural networks (ANN) is used for the prediction of erosion rates at different levels and combinations of the significant control factors. The mechanisms of erosion loss are identified from the morphologies of the worn surfaces taken using a scanning electron microscope.
Residual stress evolution and surface morphology in grinding of hardened steel following carburizing and quenching processes
Authors: Yang M. , Chen J. , Wu C. , Xie G. , Jiang X. , Li M. , He H.
Published: November 2022

In this paper, the residual stress evolution and surface morphology of quenched 20Cr2Ni4A steel after surface grinding with alumina grinding wheel was investigated. The initial compressive residual stress in the surface layer evolved into tensile stress after grinding. Since thermal stress was the dominated factor, the effect of grinding speed and grinding depth showed significant effects on the level of residual stress. The tensile stress on the ground surface increased by more than 50 % when grinding speed increased from 26 m/s to 34 m/s at the feed speed of 0.19 m/s to 0.26 m/s. The increase of grinding depth from 0.02 mm to 0.03 mm resulted in the increase rate of tensile stress varying between 54 % and 85 % at specific feed speed and grinding speed. Due to the extrusion and cutting of abrasive particles, plastic deformation and grooves were found on the machined surface. The influence of grinding heat and grinding force caused a plastic deformation layer and grinding burn layer within 20 μm.
Recycled soda lime silica glass inclusion in polytetrafluoroethylene matrix as reinforcement for microwave substrate application
Authors: Alhaji I. A. , Abbas Z. , Zainuddin N. , Ibrahim N.A. , Khamis A.M. , Lakin I.I.
Published: November 2022

Recycled soda lime silica glass‐filled polytetrafluoroethylene composites were prepared for substrate application at microwave frequencies. Various volume fractions (0.05–0.25) of the filler were dispersed in the polytetrafluoroethylene matrix. The composites’ dielectric, mechanical, and thermal properties were examined with respect to the filler content. X‐ray diffraction data established the phase structure of the polytetrafluoroethylene matrix and recycled soda lime silica glass. Scanning electron microscope micrographs revealed uniform filler distribution at lower recycled soda lime silica contents, while energy dispersive x‐ray analysis showed the purity of the composites. The tensile strength of the composites reduced from 13.5 MPa to 4.26 MPa, while the moisture absorption and density raised from 0.07 % and 2.195 g/cm3to 0.19 % and 2.228 g/cm3when the recycled soda lime silica filler volume fraction was adjusted from 0.05–0.25. The lowest coefficient of thermal expansion values was recorded at 0.25 % recycled soda lime silica volume fraction, which increased from 31.12 ppm/°C to 68.32 ppm/°C at 40 °C to 200 °C. At 0.05 filler volume fraction, the respective values of,andof the composites decreased from 2.20, 0.0017, and 29.69 ps to 2.15, 0.0015, and 29.35 ps in the 8.2 GHz–12.4 GHz range.