bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytochemical and Therapeutic Potential of Herbal Cognitive Enhancer
Authors: Bharti Abhishek , Kashyap Kalpna , Rutika  , Moudgil Akhil , Singh Bora Kundan , Kumar Dinesh
Published: September 2023

Memory is the most significant factor in distinguishing one person from another, as it is necessary to recognise one’s own self. The brain can encode, store, and retrieve information using three different types of memory. Individuals who lack these basic forms of memory are unable to create personal relationships, acquire new knowledge, and perform basic everyday duties. Memory refers to a person’s ability to encode, store, retain, and recall knowledge and past events in his or her brain. Memory gives a person the ability to learn from and adapt to previous experiences, as well as the ability to recall previously taught facts, skills, and habits. Today, poor memory, weak recall, and low retention are all typical issues. Memory deteriorates primarily because of stress and exhaustion. Memory loss, often known as age-related memory impairment, is frequent in those over the age of 40. This could be linked to the loss of hormones and proteins (growth factors) that repair brain cells as people get older. Herbs were employed to improve memory power in India throughout ancient times. Indian and Chinese cultures developed many traditional medicines from herbs to treat diminishing cognition, reverse memory loss, and improve learning power. Nootropic herbs are known for their brain-acting herbs and smart medications, which are derived from their isolated ingredients and aid to improve blood circulation in the brain. The focus of this review is on natural agents and herbs that work as memory enhancers. By using one of the herbs at a time, one can improve his or her memory.
Apium graveolens Aqueous Extract Reduced Cardiovascular Diseases and Inflammatory Biomarkers Expression in High-Fat Diet-Fed BALB/C Mice
Authors: Marbaniang Casterland , Sharan Rajeshwar Nath , Kma Lakhon
Published: September 2023

Background and Aims: Cardiovascular disease prevention has always been a high goal. The goal of this study is to investigate if Apium graveolens has any influence on cardiovascular disease risk factors, biomarkers, and inflammatory biomarkers in male BALB/c mice that have been given a high-fat diet. Methods: Apium graveolens aqueous extract was given to male BALB/c mice, and they were either fed a standard pellet or a diet composed of cholesterol (0.15%), sodium cholate (0.5%), and pure coconut oil (21%) for 12 weeks. Serum fasting glucose, a lipid profile, liver function tests, and cardiac indicators were used to evaluate the extract’s anti-dyslipidemic, hypoglycemic, hepatoprotective, and cardioprotective characteristics. Antioxidant enzyme markers in tissues were also evaluated. To evaluate inflammatory and CVD biomarkers in cardiac tissue, RT-qPCR and ELISA were used. An unpaired t-test assessed group differences. P < 0.05 showed significance. Results: The HFD control group exhibited considerably higher levels of blood glucose, lipid profile, hepatic indicators, inflammatory and cardiac markers, and lower levels of HDL-C and antioxidant enzymes. When administered orally, an aqueous extract of Apium graveolens significantly reduced blood glucose levels. Serum lipids and liver indicators returned to nearnormal levels. In addition to a considerable reduction in MDA levels, treated mice showed a large increases in catalase and reduced glutathione activities. Inflammatory and cardiovascular disease biomarker expression was reduced in the extract-treated groups. Conclusions: Apium graveolens consumption may help reduce the risk of cardiovascular disorders.
Therapeutic Influence of Nyctanthes arbor-tristis against Aluminum Chloride-induced Impairment in Wistar Rats
Authors: Prabhakar Vishnu , Mazumder Avijit , Das Saumya , Kanda Anmol , Singh Tanya
Published: September 2023

Background: Alzheimer’s Disease (AD) is a neurological illness that causes cognitive decline and memory loss. The identification of potential therapeutic agents with neuroprotective properties is of great interest in AD research. This study aimed to evaluate the neuroprotective activity of the ethanolic extract of Nyctanthes arbor-tristis in an aluminium chloride-induced dementia model in Wistar rats. Materials and Methods: Nyctanthes arbor-tristis plant specimens were collected, and ethanolic extract was prepared using standard extraction procedures. Four groups of Wistar rats were formed: control, aluminium chloride-induced dementia, extract-treated, and standard drug-treated groups. Neurobehavioral changes were measured using the elevated plus maze test and Hebb’s William apparatus. Plasma levels of amyloid-beta 1-42 (Aβ1-42) were measured. A histopathological examination of brain tissues was conducted to assess structural changes. Results: The ethanolic extract of Nyctanthes arbor-tristis demonstrated significant neuroprotective effects in the aluminium chloride-induced dementia model. Treatment with the extract improved neurobehavioral changes associated with memory impairment and improved learning and memory performance in the Hebb’s William apparatus and elevated plus maze. Moreover, the extract significantly reduced plasma levels of Aβ1-42, indicating its potential as an anti-Alzheimer’s agent p < 0.001. Histopathological analysis revealed a reduction in neuronal damage and restoration of normal brain tissue architecture in the extract-treated group. Conclusion: The ethanolic extract of Nyctanthes arbor-tristis exhibits neuroprotective activity in an aluminium chloride-induced dementia model in Wistar rats. The extract improves neurobehavioral changes related to memory, decreases plasma levels of Aβ1-42, and ameliorates histopathological alterations in the brain.
Screening of Neuroprotective Action of Hydroethanolic Extract of Leaf of Clematis buchananiana in Diabetic-Induced Neuropathy
Authors: Yadav Sanjay Kumar , Mazumder Avijit , Kumar Rajnish
Published: September 2023

Diabetic neuropathy is the most dangerous complication of diabetes which is very difficult to treat. Diagnosis in the early stage prevents worse outcomes of the illness. Determine the pharmacological effect of hydroethanolic extract of Clematis buchananiana leaves was investigated and screened for determination of neuroprotective effect in diabetic-induced neuropathy using Wistar rats. Streptozotocin normally induces diabetes within 3 days. The destruction of the beta cells present in the pancreatic gland leads to diabetes. The confirmation of diabetes was done with the help of a glucometer. The experimental models used for the assessment of analgesic activity in Wistar albino rats included the tail immersion method and acetic acid-induced writhing method. After completion of the research study, it was found that the animals treated with standard drug (Gabapentin, 100 mg/kg) had maximum analgesic action, followed by a higher dose of hydroethanolic extract of Clematis buchananiana leaf (HEELCB, 400 mg/kg). The major observation was that hydroethanolic extract of Clematis buchananiana has significant analgesic action and it validates the traditional claim of the plant as an analgesic agent.
Epistemology of Musthafa Umar’s Interpretation on the Kajian Tafsir Al-Ma’rifah YouTube Channel
Authors: Siti Zakiah Ade Rosi , Thoriquddin Moh.
Published: September 2023

A review of the epistemology of the audiovisual interpretation of the “Kajian Tafsir Al-Ma’rifah” YouTube channel delivered by Musthafa Umar is important to find out the source of interpretation, the method of interpretation, and the benchmark for the validity of his interpretation. Considering that a work of interpretation cannot be separated from various tendencies of commentators, whether it is caused by socio-cultural conditions in their environment, political influences, science, the context in which the interpretation was born, and others. Thus, studying the epistemology of interpretation becomes an urgent scientific problem to be addressed to know an interpretation. This paper is to significantly reveal the epistemology of Musthafa Umar’s thoughts in the process of interpretation on YouTube. Based on a study of the epistemology of audiovisual interpretation delivered on the “Kajian Tafsir Al-Ma’rifah” YouTube channel, it was found that Musthafa’s interpretation belongs to the category of bil ma’tsur and bil ra’yi interpretations. When interpreting Al Qur’an, he combines the tahlili (analytical) method and the maudhu’i (thematic) method. His interpretation is correct because it follows the coherence, correspondence, and pragmatic theory of truth.
Building Religious Moderation through Theophany Concept with Philosophy and Religion Approaches
Authors: Zulkarnaen Zulkarnaen , Adenan Adenan , Marhaban Marhaban , Muammar Arief
Published: September 2023

This research described an approach to building Religious Moderation according to the Theophany concept, which is an attempt to decide an attitude and action in life through a wise, unbiased perspective, and risk beneficial to many parties. Building religious moderation means forming attitudes and actions to avoid harming oneself, others, and the environment. Furthermore, achieving this process using the Theophany concept enables the formation of attitudes by considering human compassion and contempt, generosity and stinginess, as well as sensitivity and hostility, which are consistently correlated with moral and religious norms. The formation of religious moderation in one's soul brings many benefits to the world. Therefore, it is important to build this concept to determine right from wrong according to certain religious claims. These decisions are based on values, norms, morals, beliefs, and other considerations beneficial for living life. Theophany concept builds the idea that the truth in acting and behaving is God's business as the most righteous judge. In conclusion, building religious moderation is to form a personal soul with moral values beneficial for human life without being free from the justification of certain religious truths.
Sinergias entre el Acuerdo de Escazú y la Agenda 2030 sobre Desarrollo Sostenible para América Latina y el Caribe
Authors: Muñoz-Ávila Lina , Guerrero Julie Alejandra Cifuentes
Published: September 2023

Este artículo tiene como objetivo determinar las principales sinergias entre el Acuerdo de Escazú y la Agenda 2030 sobre desarrollo sostenible, que pueden ser aprovechadas para el cumplimiento integral y efectivo de los ODS. Se aplicó el enfoque cualitativo y el método deductivo, considerando como marco de análisis los principios de la democracia ambiental y del desarrollo sostenible. También se utilizó el aplicativo LinkedSDG de las Naciones Unidas que realiza un análisis de correlación semántica entre documentos de política pública y los ODS. Los resultados muestran que los pilares del Acuerdo de Escazú son habilitantes y aceleradores de la Agenda 2030, al crear las condiciones para su transversalización en la toma de decisiones, implementación a escala local y soporte a las acciones diseñadas para el cumplimiento de los ODS. Se concluye que implementar el Acuerdo de Escazú de forma articulada con las estrategias para el cumplimiento de los ODS en América Latina, es una oportunidad para la legitimación social de políticas públicas.
IMPACTOS ECONÔMICOS DA IMPLANTAÇÃO DO ECOSSISTEMA 5G NO SETOR DE TECNOLOGIA DA INFORMAÇÃO E COMUNICAÇÃO DO BRASIL
Authors: Ribeiro Guilherme David , Alves de Moura Junior Álvaro , Batista Santos Silva Vitória
Published: September 2023

Este artigo tem como objetivo avaliar alguns impactos econômicos da implementação da rede 5G no setor de Tecnologia da Informação e Comunicação (TIC) brasileiro, em decorrência das novas demandas por soluções digitais inovadoras. O artigo baseia-se nas perspectivas teóricas da economia da inovação desenvolvidas por Schumpeter e nos conceitos de paradigmas e trajetórias tecnológicas desenvolvidos pela escola Neoschumpeteriana. A metodologia adotada inclui uma revisão da literatura sobre teorias da inovação e autores que aplicam esses conceitos ao desenvolvimento do setor de TIC. Além disso, foram realizadas entrevistas com profissionais da área de TIC para avaliar suas percepções sobre os alguns dos possíveis impactos econômicos da implantação do 5G no Brasil. Os resultados obtidos por meio da literatura permitem situar os efeitos da evolução da tecnologia 5G como uma trajetória tecnológica presente nos paradigmas tecnológicos das áreas de comunicação e informação, e as a análise das entrevistas mostra que mais de 80% dos participantes acreditam que haverá um aumento na demanda por soluções digitais TIC, sendo que o setor do agronegócio será o maior impulsionador dessas demandas, com investimentos em infraestrutura de TI e adaptações de soluções já existentes em IoT, Big Data, Inteligência Artificial e softwares sob demanda.
Predictors of an unfavorable course of COVID-19
Authors: Polyakov V. Ya. , Nikolaev Yu. A. , Garina Zh. A. , Mitrofanov I. M. , Sevostyanova E. V.
Published: September 2023

The aim of the study was to identify the features of the unfavorable clinical course of a new coronavirus infection.Material and methods. The analysis of clinical data, laboratory results and comorbidity of 168 patients with a confirmed diagnosis of a new coronavirus infection aged 65,0 [57,0; 74,0] years was carried out. Two groups of patients were distinguished – 126 persons with a moderate course and with clinical recovery in the outcome of the disease and 42 persons with a severe course and a fatal outcome of the disease. Transnosological polymorbidity was assessed by the average number of nosologies corresponding to the three-digit ICD-10 rubricification, transsystemic – by the number of affected systems. Hemogram parameters, blood content of C-reactive protein, creatinine, urea, glucose, prothrombin index, international normalized ratio, activated partial thromboplastin time, platelet count, D-dimer concentration were estimated.Results. In the group of patients with fatal outcomes, compared to patients with recovery, there were statistically significantly higher indices of transnosological and transsystemic polymorbidity (1.5 and 2 times, respectively), they were more likely to have ischaemic heart disease, myocardial infarction, transient ischemic attack in anamnesis, atrial fibrillation, chronic heart failure; blood concentration of C-reactive protein, fasting glucose, urea, D-dimer in the blood serum was higher, the number of thrombocytes was less.Conclusions. A high degree of transnosological and transsystemic polymorbidity, a history of myocardial infarction and transient ischemic attack, comorbid chronic heart failure, atrial fibrillation, an increase in D-dimer, CRP content, and a decrease in platelet number are predictors of severe course and the lethal outcome of COVID-19.
Feminicídio e as dimensões da violência de gênero no sistema de justiça criminal
Authors: Soares Taísa Gabriela , Ghiringhelli de Azevedo Rodrigo , Bestetti de Vasconcellos Fernanda
Published: September 2023

Este artigo busca verificar qual é a compreensão e o papel dos atores do Sistema de Justiça Criminal (SJC) diante das dimensões da violência letal de gênero, a partir da criminalização do feminicídio. Para isso, realizamos uma pesquisa de campo delimitada na análise documental de inquéritos policiais, processos penais e julgamentos do Tribunal do Júri sobre feminicídios ocorridos na cidade de Pelotas, no estado do Rio Grande do Sul (RS), entre os anos de 2015 e 2019. O objetivo geral da pesquisa é analisar de que forma a compreensão das dimensões da violência de gênero pelos atores do SJC afeta as vítimas (diretas e indiretas) dos crimes de feminicídio e, em última instância, como comunicam a violência letal de gênero para a sociedade. De modo específico, partimos da análise teórica da violência letal de gênero desde a perspectiva de um fenômeno social, até a construção da figura penal típica do feminicídio e sua posterior recepção pelos atores do SJC. Por fim, desenvolvemos a análise documental buscando apontar obstáculos concretos a uma pretendida política de observação da diversidade de gênero. Metodologicamente, a pesquisa é amparada na sociologia jurídica, com pesquisa de campo baseada no método indutivo, em pesquisa qualitativa e quantitativa, com técnicas fundamentadas na análise bibliográfica e documental. A pesquisa empírica foi desenvolvida com base na coleta de dados a partir de formulários estruturados.
Entre liberdades e prisões
Authors: Baptista Bárbara Gomes Lupetti , Duarte Fernanda , Mario Iorio Filho Rafael
Published: September 2023

Partindo da afirmação de que a sociedade brasileira se estrutura de forma hierarquizada, reproduzindo um ethos aristocrático em contraposição a uma ordem republicana, podemos reconhecer que, no plano jurídico, a desigualdade se opera em dois níveis: no aspecto normativo – por meio da elaboração das leis – e na administração dos conflitos, quando da aplicação das leis, especialmente pelo Judiciário. Neste texto, pretendemos problematizar o modo como as instituições judiciárias no Brasil internalizam e (re)produzem desigualdades jurídicas – o que se tornou mais evidente com a pandemia de Covid-19 – e suas consequências para a esfera de direitos dos brasileiros. Para tanto, pretendemos descrever uma categoria de casos (os casos de pedidos de liberdade de réus presos, justificados pela superveniência da pandemia da Covid-19 e respaldados na Recomendação n. 62/2020 do CNJ), que ajudam a revelar essa chave da desigualdade.
A forma e o conteúdo das audiências de custódia no Rio de Janeiro
Authors: Campos Marcelo
Published: September 2023

O objetivo deste artigo é descrever as principais práticas do sistema de justiça criminal e seus agentes no cotidiano do sistema de justiça criminal fluminense a partir das Audiências de Custódia, na cidade do Rio de Janeiro, no interior do presídio de Benfica. Buscou-se verificar se essas inovações jurídicas trouxeram mudanças no âmbito da ampliação das garantias e direitos fundamentais dos acusados; ou se, de modo contrário, tais inovações reforçam a centralidade da pena de prisão na atualidade e a inquisitorialidade do nosso sistema. Partindo, especialmente, dos casos relacionados às criminalizações por drogas, a pesquisa etnográfica observou mais de 150 audiências, entre os anos de 2018 e 2020. Os dois principais resultados são: as audiências de custódia não criaram um espaço de escuta do réu, ou seja, a chamada oralidade do réu; e a presença da pessoa incriminada perante os operadores não possibilita necessariamente a visualização de eventuais práticas não condizentes com a forma legal da prisão em flagrante. Logo, a oralidade, universalidade e prevenção à tortura – princípios fundadores e legitimadores dessa forma de justiça no Brasil – foram deixadas de lado pela hegemonia do conteúdo da inquisitorialidade e centralidade da pena de prisão no interior do sistema de justiça criminal. O que, por conseguinte, reproduz uma “nova” forma jurídica como hierárquica, não oral e não universal.
As the Pendulum Swings?
Authors: Bisharat George
Published: September 2023

This article reviews recent oscillations in crime policy in the City and County of San Francisco, California, particularly as represented in the 2019 election of Chesa Boudin as District Attorney, followed in 2022 by his recall and removal from office. Boudin had run as a progressive prosecutor, promising fundamental reforms to local crime policy, so the question arises: what, if anything, does his recall just over halfway through his 4-year term of office indicate for the future of progressive prosecution in San Francisco, but equally importantly, throughout the United States? We believe the recall does not signify a broad public retreat from progressive prosecution, which still enjoys wide support in many locales throughout the country, but instead reflects mostly singular characteristics of the San Francisco political system coupled with unique impacts of the COVID pandemic. Still, it represents one variant of the fierce organized opposition that progressive prosecution has engendered everywhere it has been implemented, and therefore, may offer lessons for how to forge ahead with reform measures against determined political resistance.
ATENÇÃO PERFORMATIVA COMO ESTRATÉGIA PEDAGÓGICA NO ENSINO DE TEATRO
Authors: Passos Pires Igor , Icle Gilberto
Published: September 2023

O artigo trata da atenção performativa como recurso por intermédio do qual professores e professoras de teatro da Educação Básica solucionam as dificuldades do cotidiano escolar. Apresenta-se a pesquisa realizada com entrevistas semiestruturadas com seis professores/as do Distrito Federal, no Brasil. Propõe-se a atenção performativa como possibilidade de ressignificação do espaço escolar. Debate-se os conceitos de professor-performer e estudante-performer no intuito de mostrar as possibilidades de horizontalidade e criação da atenção performativa. Por fim, defende-se a atenção performativa como dispositivo para a solução de problemas e para a criação em teatro na escola.
Can the “Five Challenges” Overcome the Problem of “Reform Without Change” in Medical Education? Reexamining the “Hidden Curriculum”
Authors: Murakami Manabu , Takeuchi Akiko , Jin Shigeki , Matoba Kotaro
Published: September 2023

N/a.
TALENT MANAGEMENT IN ORGANIZATIONS
Authors: Amelia Emi , Rofaida Rofi
Published: September 2023

This research aims to take a more comprehensive and in-depth look at the articles that have appeared on Talent Management in the last 5 years (2017- 2022). This research method uses the Systematic Literature Review by following the PRISMA stages. There were 40 articles selected in this study from an initial search of 969 articles. Results The findings of this study indicate that the scope of talent management is related to roles, processes, definitions and issues, as well as talent management strategies in an organization and the impact of talent management on employees and organizational performance
peran penting dewan pengawas syariah untuk lembaga keuangan berbasis syariah
Authors: Syarofi Muhammad , Putri Lutfianah
Published: September 2023

Abstract

Semakin berkembangnya lembaga-lembaga keuangan syariah trend mengunakan lembaga keuagan islam seperti lembaga keuangan syariah yang didalamnya terdiri atas dua jenis yaitu lembaga perbankan dan juga lembaga keuangan non perbankan ini di Indonesia semakin banyak para penggunanya/nasabahnya dan semakin berkembang pula lembaga-lembaga tersebut, maka dari itu didalam sebuah lembaga yang menawarkan produk-produk yang berbasis syariah ini dibutuhkan suatu badan yang bernama Dewan Pengawas Syariah di setiap lembaga keuangan syariah tersebut. Artikel ini dibuat oleh penulis yang memiliki tujuan agar para pembaca nantinya mengetahui seberapa pentingnya keberadan DPS dalam dunia lembaga keuangan syariah, hal tersebut sangat penting karena dalam menjalankan sebuah kegiatan ini lembaga keuangan syariah diharuskan agar sesuai dengan prinsip ketaatan syariah.
Description of Biofilm Density on Glass Ionomer Cement Modified by 5% Hydroxyapatite from the Synthesis of Chicken Eggshells
Authors: Saputri Dewi , A. Gani Basri , Handysha Meiditya
Published: September 2023

Background: Oral microbiome biofilms can appear on all surfaces of the oral cavity as well as restorative materials such as Glass Ionomer Cement (GIC). GIC is considered superior because it has the ability to produce fluoride, which has a cariostatic effect, but the fluoride produced is inadequate to inhibit the growth of biofilms, so modifications were made by adding hydroxyapatite from eggshell. Purpose: To evaluate the levels of hydroxyapatite contained in chicken eggshells and to assess the description of oral microbiome biofilm density on the surface of hydroxyapatite-modified GIC from chicken eggshell synthesis. Methods: The research group was divided into a control group, namely GIC without the addition of hydroxyapatite, and a treatment group, namely GIC with the addition of 5% hydroxyapatite. The oral microbiome biofilm obtained from the voluntary dental plaque swab was cultured on the specimen surface at a time span of 24 hours, 48 hours, and 72 hours. Biofilm density was examined using Scanning Electron Microscopy and analyzed using ImageJ software. Results: The average density of biofilm on GIC without the addition of hydroxyapatite at 24 hours, 48 hours, and 72 hours, respectively, was 2,640.02 p/μm, 1,130.08 p/μm, 16,797.33 p/μm. Meanwhile, the GIC with the addition of hydroxyapatite was 1,921.52 p/μm, 1.029 p/μm, and 5,764.50 p/m. Conclusion: Statistical analysis performed showed that time affected the density value of the oral microbiome formed, and the two groups of materials had different effects in reducing biofilm density descriptively but statistically did not have a significant difference.
Analysis of antioxidant and antibacterial activity of cocoa pod husk extract (Theobroma cacao L.)
Authors: Rahayu Yani Corvianindya , Setiawatie Ernie Maduratna , Rahayu Retno Pudji , Ramadan Doaa Elsayed
Published: September 2023

Background: Theobroma cacao bean manufacturing worldwide includes undesired byproducts such as cocoa pod husks. Cocoa pods contain a variety of beneficial chemicals, including polyphenols. Polyphenols have a vital function in the treatment of many illnesses and infections of the oral cavity. This is due to their vital qualities in the oral cavity, including anti-inflammatory, antibacterial, and antioxidant actions. Purpose: The goal of this study was to look at the antioxidant content and antibacterial activity of cocoa pod husk extract (Theobroma cacao L.) against Phorphyromonas gingivalis (P. gingivalis) and Streptococcus mutans (S. mutans). Methods: Cocoa pod husk extract was produced using an ultrasonic homogenizer and 70% ethanol. Thin layer chromatography and the Folin–Ciocalteu test were used to determine the phytochemical content and total phenolic content of the extract. The 2,2-diphenyl-1-picryl-hydrazyl-hydrate technique was used to measure antioxidant activity. Minimum inhibitory concentration (MIC) tests were used to measure the antibacterial activity of ethanolic extract at concentrations of 1, 4, 8, 16, 32, and 64 mg/ml using a deep-well broth microdilution technique. Results: The presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids was discovered in the cocoa pod husk extract. Conclusion: The antioxidant activity of the extract was significant (IC50 = 62 ppm), and the MIC of P. gingivalis and S. mutans was 16 mg/ml and 8 mg/ml, respectively.
Treatment of skeletal Class II with retrognathic mandible in growing patient using modified sagittal guidance twin-block appliance
Authors: Lubis Hilda Fitria , Yanita Sherliana
Published: September 2023

Background: Class II discrepancies were primarily perceived as sagittal problems. Class II malocclusions usually cause aesthetic and functional problems, depending on the degree of anterior-posterior mismatch and interaction with adjacent soft tissues. Purpose: This case report aimed to evaluate the effect of modified sagittal guidance twin-block (SGTB) for Class II Skeletal and Dental Changes in a growing patient. Case: A 10-year-old patient presented with her parents and complained mainly of aesthetic problems. Diagnosis showed skeletal Class II pattern (ANB 6º) with retrognathic mandible, angle Class II molar relationship, convex facial profile, lower dental midline shift, crowding in the lower anterior teeth, and incompetent lips. Case Management: A growth modification treatment plan was considered for the patient, using modified SGTB. Both bonded and removable had the same design. In the SGTB, the bite block was angled at 70º, pushed toward the occlusal plane to maximize horizontal force toward the mandible. As a result, the mandible is guided forward and optimally positioned during occlusion. Conclusion: An ideal overjet and slight correction on lower anterior crowding teeth were achieved after full-time wear of a modified SGTB for 12 months. A modified SGTB appliance is effective in treating skeletal Class II with a retrognathic mandible.
Comparison outcome of open and close reduction treatments for parasymphysis mandibular fractures
Authors: Fardhani Annisa , Rizqiawan Andra , Mulyawan Indra , Anugraha Ganendra
Published: September 2023

Background: Mandibular fracture is a condition of mandibular discontinuity. The treatment aims to reconstruct the appropriate anatomical position. Reduction is the process of repositioning fracture fragments to their original anatomical positions, which can be done by open and closed techniques. Open reduction is more invasive, and the possibility of nerve or blood vessel injury and infection postoperatively is greater. Closed reduction also has postoperative complications such as muscle atrophy, periodontal tissue and mucosa damage, speech disorders, and nutritional disorders. In the final determination of the treatment plan, the advantages, disadvantages, and risks of each treatment and the risk of complications should be sufficiently discussed with patients and the patient’s guardians. Purpose: This case aims to compare the outcome of open reduction and internal fixation (ORIF) with closed reduction treatment in the management of mandibular parasymphysis fractures. Cases: Two case studies of mandibular parasymphysis fractures. Clinically, each patient had mandibular displacement and occlusion disturbance before treatment. Case Management: The treatment plan is considered by the patient’s age and fracture type. One patient received ORIF, and the other received close reduction treatment with gradual repositioning. Malocclusion after treatment was absent in both cases. Conclusion: Open reduction is recommended for displaced parasymphysis fractures. In cases where the open reduction technique cannot be performed, the closed technique can be an alternative, especially on non-displaced or minimally displaced parasymphysis fractures.
Supporting factors and coping mechanisms for quality of life: Housewives and career women’s perspective
Authors: Priyantini Diah
Published: September 2023

Introduction: The quality of life between housewives and career women facing chronic hepatitis B shows differences in coping abilities, and is influenced by several causal factors. This study aimed to explore the quality of life of housewives and career women experiencing chronic hepatitis B.Methods: This qualitative phenomenological study consisted of 14 women (seven housewives and seven career women) with chronic hepatitis B. The instruments used to collect information from participants were in-depth interviews about the supporting factors and coping mechanisms that influenced their quality of life. Participants were recruited using purposive sampling, and data were analyzed using the Colaizzi technique to describe the theme.Results: The results showed two major themes from the participants’ answers: supporting factors and coping mechanisms. The sub-themes of partner support, family support, peer group support, and social community support made up the supporting factors. Meanwhile, coping mechanisms consisted of adaptive coping, improving knowledge, interacting with other people, problem-solving, and changing lifestyles and controlled routines. On the other hand, maladaptive coping caused participants to isolate, think negatively, grieve excessively, and show stress or depression symptoms.Conclusions: Housewives with chronic hepatitis B have a better quality of life than career women because they are more accepting and have better-coping mechanisms in facing this condition. The research study results can be implicated in nursing interventions to improve the coping abilities of women with chronic Hepatitis B.
Keywords: chronic hepatitis B; coping mechanism; quality of life; supporting factors; women
Factor analysis of Pregnant Women’s Concerns Scale of Contracting COVID-19 questionnaire
Authors: Bilgin Zümrüt , Aktaş Büşra
Published: September 2023

Introduction: The global pandemic caused by the emergence of COVID-19 resulted in increased anxiety, notably among pregnant women. Uncertainties linked to the increased concerns due to virus and this led to realizion of emphasing the necessity for tools to evaluate the fear contracting it. This study aims to create a Scale for Pregnant Women’s Concerns of being Contracted to COVID.Methods: A preliminary 5 point Likert-type scale comprising 29 items was distributed among 285 pregnant women. The statistical analysis conducted on the responses from 285 invidividuals that contracted COVID-19. The scale’s validity and reliability were assessed through exploratory and confirmatory factor analysis, also the outcome of computation Cronbach’s alpha coefficients taken into assesment. Results: According to the factors analysis the scale components consisting 12 items, and 2 factors explained 51.81% of the overall variation. The Cronbach’s alpha internal consistency coefficient was determined to be 0.828. The Pregnant Women’s Concerns Scale for Contracting COVID-19 is a valid scale for Turkish pregnant women. Conclusion: Psychosocial characteristics of pregnant women affect their concerns of contracting COVID-19. It is recommended to apply this scale to sample groups from different cultures. This scale is a valid and reliable instrument for evaluating pregnant women’s apprehensions regarding COVID-19 infection. Implementing this scale within prenatal health services will aid in identifying and addressing COVID-19 related concerns among individuals at an early stage pregnancy.
Keywords: COVID-19 concern; pregnancy; reliability; scale development; validity
Comparing the Effect of Repetitive Transcranial Magnetic Stimulation Therapy and Aerobic Exercise as an Add-on Therapy on the Cognitive Function of Patients with Depression
Authors: Muhammad Ikhwan , Putra Hening Laswati , Kusumawardani Martha Kurnia , Konginan Agustina , Fazia
Published: September 2023

Background: Cognitive disturbances are a major cause of disability in depression. The antidepressant medication effectively improves cognitive function. However, its adverse effect limits its use, so add-on treatment is needed to support its effectiveness.
Aim: This study aims to compare the efficacy of aerobic exercise and repetitive transcranial magnetic stimulation (rTMS) as an add-on treatment for improving cognitive function.
Material and Methods: Twenty-seven patients with first episodes of moderate and severe depression were recruited from the outpatient psychiatry clinic to join this randomized controlled trial. Participants were allocated to three groups: antidepressant only, antidepressant with add-on aerobic exercise, and antidepressant with add-on rTMS therapy. All participants received 2 weeks of intervention. Cognitive functions were assessed using Montreal Cognitive Assessment (MOCA).
Results: No differences were found in baseline characteristic data between groups. Total MOCA score increased after intervention in a group with no add-on treatment (p=0.007), with add-on aerobic exercise (p=0.011), and with add-on rTMS therapy (p=0.017). Hence, there was no between-group difference (p=0.222). The MOCA subtest analysis revealed between-group differences in changes in delayed recall subtest score (p=0.01). The group with add-on rTMS therapy improved better than the group with antidepressants only (p=0.005).
Conclusion: The addition of rTMS therapy resulted in better improved delayed recall function than the addition of aerobic exercise or without any add-on treatment. This finding supports the application of rTMS therapy as an add-on treatment to improve the cognitive function of patients with depression.
Effect of Topical Gel Ethanol Extract of Gotu Kola Leaf (Centella Asiatica (L.) Urban) on Wound Healing in a White Male Rat (Rattus Norvegicus) Induced by Streptozotocin
Authors: Dewi I Dewa Ayu Sudiari , Fatimah Nurmawati , Kuswarini Sutji
Published: September 2023

Background: Diabetes mellitus (DM) can have a number of consequences, one of which is diabetic neuropathy, which can cause sores, notably in patients' feet. Wound therapy with synthetic drugs in diabetes is still not functioning as well as expected. Centella Asiatica (L.) Urban has been demonstrated to promote wound healing through a variety of mechanisms, including collagen synthesis stimulation, fibroblast proliferation stimulation, antiulcer, antibacterial, and antioxidant activity. Pharmaceutical treatments for wound healing are routinely utilized upon the assumption that a moist wound is a gel.
Aims: The purpose of this study was to see how a topical gel ethanol extract of gotu kola (Centella Asiatica (L.) Urban) promoted wound healing in streptozotocin (STZ)-induced white male rats (Rattus Norvegicus).
Methods: This is an experimental study using twenty white male rats (Rattus Norvegicus) caused by STZ. The rats were placed into four groups, each with five rats. These four groups are the control group, the treatment group P1 (ethanol gel gotu kola leaf at 2.5% concentration), the treatment group P2 (ethanol gel gotu kola leaf at 5% concentration), and the treatment group P3 (ethanol gel gotu kola leaf at 10% concentration). STZ was used to promote blood sugar elevation in the rats. The wound healing rate was estimated by comparing the wound healing rates of each group using macroscopic observation.
Result: The findings of this study revealed that extract gel gotu kola leaf concentration applied to the wound on days 4, 7, 11, and 14 has a statistically significant influence on wound healing (p=0.000).
Conclusion: Based on the research conducted, it can be concluded that gotu kola extract gel has a significant influence on the rats’ wound healing.
THE EFFECT OF PRESERVICE TEACHERS' INFORMATION AND COMMUNICATION TECHNOLOGIES COMPETENCIES ON ACADEMIC SELF-EFFICACY AND ACADEMIC ACHIEVEMENT
Authors: Bahar Hüseyin Hüsnü , Öz Recep , Kayalar Murat Tolga
Published: September 2023

The purpose of this study was to measure the ICT competency levels and academic self-efficacy perception levels of preservice teachers and to determine if those levels were a significant predictor of their academic self-efficacy. For this purpose, the data were obtained from 411 volunteer students studying in the second, third, and fourth grades of the Teacher Training Undergraduate Programs at Erzincan Binali Yıldırım University Education Faculty. In total, 133 male and 278 female students participated in the study. As data collection tools, the Personal Information Form, the Information and Communication Technology Competencies Scale for Pre-service Teachers (ICTC-PT) developed by Tondeur et al. (2017) and adapted to Turkish language and culture by Alkan and Sarıkaya (2018) as well as the Academic Self-Efficacy Scale (ASES) developed by Kandemir (2010) were used. The Personal Information Form included information regarding department, grade, gender, and GPA. The reliability analyses of the scales were carried out, as well as multiple and stepwise regression analyses and descriptive statistics to address the research questions. As a result, it was determined that pre-service teachers' perception of ICT self-efficacy was at a high level. A moderate level of perception was observed in the sub-dimensions of ASE-CAP, ASE-AE, and ASE-APL among the participants. ICT-ID was found to be a significant predictor of ASE-CAP, but not of CSP-ICT. Although CSP-ICT was more closely related to general competencies, ICT-ID appeared to be more closely related to the skills required by the teaching profession. Based on the results of the study, the ASE-CAP, ASE-APL, and ICT sub-dimension scores were not significant predictors of GPA, whereas the ASE-AE score was a significant and positive predictor of GPA. It could be concluded from these findings that experiences and activities aimed at improving students' self-efficacy perceptions contributed positively to academic achievement in teacher training programs.
Comparison Of Artificial Neural Network Backpropagation and Garch Methods In Predicting Stock Price (Case Study: Indosat Shares 2012 – 2022)
Authors: Ena Maktisen
Published: September 2023

Abstract: One of the problems encountered in the forecasting process is the problem of heteroscedasticity. Heteroscedasticity occurs a lot, especially in stock data. Pt Share Price Indosat (tbk) from March 6 2012 – January 18 2022 has fluctuated from time to time, so the variance is heteroscedasticity. The Generalized Autoregressive Conditional Heteroskedasticity (GARCH) model and Artificial Neural Network Backpropagation (ANNBP) are methods that can be used on data with heteroscedasticity. The aim of this research is to obtain models and forecasting results from GARCH and ANN Backpropagation. In this study, the two models were compared based on the smallest MAPE value. This study uses daily data on the closing of Indosat shares. Forecasting is done on Indosat stock closing data, the total data is 2453 data divided into two parts, namely 80% training data totaling 1962 data and 20% training data totaling 491 data. Forecasting results from the GARCH model obtained a MAPE value of 11.04%, and the ANN Backpropagation model with 7 input layers, 20 hidden layers, obtained a MAPE value of 7.01%. Thus, the best model for predicting Indosat's share price in this study is the backpropagation model.
Direct Cu, Fe, and Ni Ions Multicomponent Analysis Using UV-Vis Spectrophotometric Method
Authors:   Institut Teknologi Sepuluh Nopember, Suprapto Suprapto , Ni'mah Yatim Lailun
Published: September 2023

This study presents a direct multicomponent analysis method using UV-Vis spectrophotometry to determine Cu(II), Fe(III), and Ni(II) ion content without prior complexation or separation. Single and multivariate regression was used to predict metal ion content, and the resulting model was trained and validated using a dataset of 25 multi-component samples. The mean recoveries for Cu(II), Fe(III), and Ni(II) using linear and ridge regression based only on absorbance at 805 nm were 99.97% and 101.6%, 95.42% and 95.65%, and 99.43% and 99.99%, respectively, for the 20% test data. The mean recoveries for Cu(II), Fe(III), and Ni(II) using linear and ridge regression based only on absorbance at 805 nm were 92.27% and 95.03%, 125.3% and 124.11%, and 104.15% and 105.52%, respectively, for the test solution outside of the training data. These results demonstrate the effectiveness of the multivariate UV-Vis spectrophotometric method for the simultaneous determination of Cu(II) and Ni(II) in multicomponent samples, which meets the analysis standard and can be successfully applied. Finally, the study sheds light on the influence of spectral interference on the accuracy of regression models. It highlights the importance of carefully selecting the wavelengths used as predictors in such models. This can have significant implications for developing and validating analytical methods, particularly in cases where multiple analytes were present in a sample.
Quality Analysis of Cloth Masks: Study of Material Types on Physical, Chemical, and Antibacterial Properties
Authors:   Universitas Sebelas Maret, Wahyuningsih Sayekti , Ramelan Ari Handono , Handayani Selfi , Wiyono Nanang , Raharjo Sentot Budi , Supriyanto Agus , Lestari Windy Ayu , Hartati Retno , Hidayat Rahmat
Published: September 2023

Utilizing personal protective equipment (PPE) is the important requirement for controlling and preventing of Covid-19 virus spread. The awareness of mask-wearing among the citizen and the development of fabric mask testing methods based on Indonesian Standards through the implementation of SNI 7648: Textile – Test of the air permeability on fabric; SNI 20743: The evaluating method of antibacterial properties using biological aerosol S. aureus and E. coli; SNI/ISO 4920: The surface wetness testing. This study shows that we need to understand and choose fabric masks correctlybesides being standardized. Fabric types influence the performance of the mask while protecting the user
In Silico Study of Monascus sp. Pigment Derivatives as Anticardiovascular Candidate
Authors: Zain Dichy Nuryadin , Yuliana Anna
Published: September 2023

Background: Cardiovascular disease is the leading cause of death in the world. The therapeutic activity of Monascus sp. pigment can act as an anticardiovascular agent. Research on Monascus sp. pigment is rapidly developing, including the discovery of new pigments, the methods used, and their identification. Currently, there are 57 dyestuff compounds that have been successfully isolated from Monascus molds. So, researchers conducted an in-silico study of Monascus sp. Objective: To determine whether it can have better interactions and activities as an anticardiovascular medicine candidate. Method: PAK1 is used as a receptor for anticardiovascular drugs. 57 test compounds were carried out for ligand preparation and application of Lipinski's rule of five by using MarvinSketch software, ADME prediction and toxicity testing using PreADMET, the docking process using Autodock tools, and visualization using Discovery Studio. Results: The results of the docking analysis are seen from the values of binding affinity consecutively. compound R3 (-8.74 kcal/mol), red shandong (-8.16 kcal/mol), and monaphilol (-8.14 kcal/mol) are lower than the comparison compound bisoprolol (-6.44 kcal/mol), which shows that the three compounds have better interactions than the comparison compounds. Conclusion: Derivative compounds from Monascus sp. Pigment are predicted to have better interactions and can be used as anticardiovascular medicine candidates. Keywords: Monascus sp., pigment, anticardiovascular, in silico, PAK1, ADME, and toxicity
STUNTING IN ISLAMIC FAMILY LAW: CAUSE DAN SOLUTION
Authors: Rosil Fathony Moh
Published: September 2023

This article discusses the causes and solutions of stunting and its effect on household harmony. In addition, this article also discusses the government's efforts in overcoming health problems as Perpres Number. 72/2021 concerning the Acceleration of Stunting Reduction. The method that used in this article is descriptive qualitative which is library research. Article data in the form of literature data, especially books and equipped with other documents that related to stunting both causes and solutions. The results of the article show that stunting is a condition that a person's height is shorter than the height of other people in general (who are the same age). Stunting is a chronic nutritional problem caused by multi-factorial and intergenerational nature. Stunting is also something that is not expected to happen in a household, in Indonesia stunting is a health problem that must be taken seriously. However, in practice, stunting still occurs a lot and is a problem today. Widespread incidence of stunting hampers economic growth, increases poverty, and widens inequality in households.
BEST INTEREST FOR CHILDREN IN PERMA NO. 5 OF 2019 CONCERNING GUIDELINES FOR TRYING DISPENSATION MARRIAGE APPLICATION CASES
Authors: Uyun Qurratul Uyun , Maida Hafidz  , Madah Rahmatan
Published: September 2023

Child marriage has a negative impact on individuals and the environment. Children who marry at an early age do not get the rights they should have so that, which has an impact on divorce and domestic violence due to the unpreparedness of children in building a household; things like that can also affect social structure and order in society, which ends in threats to children's welfare. Children with welfare problems need protection and guidance like children of the same age. The type of research used is library research. The descriptive-qualitative method uses a theoretical approach and facts through the information media, judge's decisions, articles and other sources. The results of the study show that the best interests of the child in PERMA No. 5 of 2019 are all actions that must be considered to ensure the protection, care, welfare, survival and development of children, including efforts to help prosper the growth and development of children and improve family life.