bluuebunny/crossref_metadata_2025 huggingface dataset:
Subjective Evaluation on the Annoyance of Environmental Noise Containing Low-Frequency Tonal Components
Authors: Yonemura Miki , Lee Hyojin , Sakamoto Shinichi
Published: July 2021

Recently in Japan, noises from wind turbines and domestic use heat sources sometimes cause an increase in noise annoyance owing to low-frequency tonal components. The purpose of this study was to investigate the effects of the tonal components on the annoyance of the environmental noise. The authors conducted an auditory test in the laboratory to evaluate the annoyance of tonal noise using a seven-step rating method. The stimuli were composed of a broadband noise modeling of the environmental noise (25, 30, and 35 dB) and a low-frequency tonal component. With the tonal component added to the broadband noise, the frequency and tonal audibility were varied to 40, 50, 100, 200, and 400 Hz and 0, 3, 6, 9, and 12 dB, respectively. The amount of increase in annoyance owing to the addition of the tonal component was quantitatively evaluated as a tonal adjustment by comparing it with broadband noise. As a result, tonal adjustment ranged from 0 to 7 dB, and the higher the tonal frequency, the larger the value. For the test background noise level, the lower the background noise level of the test sound, the greater the value. This trend suggests that the influence of tonal components on subjective impressions is stronger in quiet environments such as residential areas. This result may provide a basis for the evaluation method, which varies the penalty in the noise evaluation according to the frequency of the pure tones and the noise level.
Validation and Adjustment of the Patient Experience Questionnaire (PEQ): A Regional Hospital Study in Norway
Authors: Addo Seth Ayisi , Mykletun Reidar Johan , Olsen Espen
Published: July 2021

This paper assesses the psychometric qualities of the Patient Experience Questionnaire (PEQ), thereby validating a patient-oriented measurement model in a hospital environment, and modifies the model based on empirical results. This study employed survey data gathered by the Norwegian Institute of Public Health from adult inpatients at somatic hospitals in the Health South-East RHF in Norway. The survey engaged 4603 patients out of 8381 from five main hospitals in the region. The study found that an eight-factor model of the PEQ generally showed good fitness to the data, but assessment of discriminant validity showed that this was not the optimal factor solution among four of the eight dimensions. After comparing models, the study proposed a model with a second-order factor for four of the factors: “nurse services”, “doctor services”, “information”, and “organization”, collectively named “treatment services”. The proposed model demonstrated good validity and reliability results. The results present theoretical and practical implications. The study recommends that inferential analyses on the PEQ should be done with the second-order factor. Furthermore, a revision of the PEQ is recommended subject to more confirmatory studies with larger samples in different regions. The study indicates a second-order factor structure for assessing and understanding patient experiences—a finding which has both theoretical and managerial implications.
Predicting Continued Participation in Government-Initiated Public Sports Clubs: The Role of Prior Knowledge and Awareness through Health Communications
Authors: Won Doyeon , Kim Hyung-Hoon , Bae Jung-Sup
Published: July 2021

Physical activity is the most effective preventive medicine in enhancing our physical health and subjective wellbeing. Since 2013, the South Korean government has introduced and developed the public sports club system as a way to promote exercise and the health of the general public. The current study investigated factors underlying the general public’s desires and intentions to join or participate in a public sports club (PSC) using the model of goal-directed behavior (MGB). Data were collected from 254 college students who had prior experience of participating in at least one PSC and were primarily analyzed using structural equation modeling (SEM). The results suggest that, among the five MGB determinants, the positive anticipated emotions and perceived behavioral control were significantly associated with participants’ desires, and, in turn, their desires were significantly related to their intention to participate in PSCs. Meanwhile, the respondents’ prior experience was marginally but significantly associated with desire but not with behavioral intention. Prior knowledge (through health communications) was significantly related to attitude, desire, and behavioral intention. Overall, the findings support the use of positive anticipated emotions, perceived behavioral condition, prior knowledge, and desire as indicators of participation behavior in the PSC context, and may aid the development of health communication and interventions aimed at encouraging future participation.
In-House Filtration Efficiency Assessment of Vapor Hydrogen Peroxide Decontaminated Filtering Facepiece Respirators (FFRs)
Authors: Al-Hadyan Khaled , Alsbeih Ghazi , Nobah Ahmad , Lindstrom Jeffrey , Falatah Sawsan , Faran Nawarh , Al-Ghamdi Salem , Moftah Belal , Alhmaid Rashed
Published: July 2021

To cope with the shortage of filtering facepiece respirators (FFRs) caused by the coronavirus disease (COVID-19), healthcare institutions have been forced to reuse FFRs using different decontamination methods, including vapor hydrogen peroxide (VHP). However, most healthcare institutions still struggle with evaluating the effect of VHP on filtration efficiency (FE) of the decontaminated FFRs. We developed a low-cost in-house FE assessment using a novel 3D-printed air duct. Furthermore, we assessed the FE of seven types of FFRs. Following 10 VHP cycles, we evaluated the FE of KN95 and 3M-N95 masks. The 3M-N95 and Benehal-N95 masks showed significant lower FE (80.4–91.8%) at fine particle sizes (0.3–1 µm) compared to other FFRs (FE ≥ 98.1%, p < 0.05). Following 10 VHP cycles, the FE of KN95 masks was almost stable (FE stability > 99.1%) for all particle sizes, while 3M-N95 masks were stable only at 2 and 5 µm (FE stability > 98.0%). Statistically, FE stability of 3M-N95 masks at 0.3, 0.5, and 0.7 µm was significantly lower (p ≤ 0.006) than 2 and 5 µm. The in-house FE assessment may be used as an emergency procedure to validate the decontaminated FFRs, as well as a screening option for production control of FFRs. Following VHP cycles, both masks showed high stability at 5 µm, the size of the most suspected droplets implicated in COVID-19 transmission.
Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review
Authors: Pinos Helena , Carrillo Beatriz , Merchán Ana , Biosca-Brull Judit , Pérez-Fernández Cristian , Colomina María Teresa , Sánchez-Santed Fernando , Martín-Sánchez Fernando , Collado Paloma , Arias Jorge L. , Conejo Nélida M.
Published: July 2021

In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. These compounds could act as endocrine-disrupting chemicals (EDC) that may interfere with hormone activity related to several mechanisms involved in body weight control. The main objective of this study was to systematically review the data provided in the scientific literature for a possible association between prenatal and postnatal exposure to pesticides and obesity in offspring. A total of 25 human and 9 animal studies were analyzed. The prenatal, perinatal, and postnatal exposure to organophosphate, organochlorine, pyrethroid, neonicotinoid, and carbamate, as well as a combined pesticide exposure was reviewed. This systematic review reveals that the effects of pesticide exposure on body weight are mostly inconclusive, finding conflicting results in both humans and experimental animals. The outcomes reviewed are dependent on many factors, including dosage and route of administration, species, sex, and treatment duration. More research is needed to effectively evaluate the impact of the combined effects of different pesticides on human health.
Spatial Patterns of Endometriosis Incidence. A Study in Friuli Venezia Giulia (Italy) in the Period 2004–2017
Authors: Catelan Dolores , Giangreco Manuela , Biggeri Annibale , Barbone Fabio , Monasta Lorenzo , Ricci Giuseppe , Romano Federico , Rosolen Valentina , Zito Gabriella , Ronfani Luca
Published: July 2021

Background: Diagnosis of endometriosis and evaluation of incidence data are complex tasks because the disease is identified laparoscopically and confirmed histologically. Incidence estimates reported in literature are widely inconsistent, presumably reflecting geographical variability of risk and the difficulty of obtaining reliable data. Methods: We retrieved incident cases of endometriosis in women aged 15–50 years using hospital discharge records and pathology databases of the Friuli Venezia Giulia region in the calendar period 2004–2017. We studied the spatial pattern of endometriosis incidence applying Bayesian approaches to Disease Mapping, and profiled municipalities at higher risk controlling for multiple comparisons using both q-values and a fully Bayesian approach. Results: 4125 new cases of endometriosis were identified in the age range 15 to 50 years in the period 2004–2017. The incidence rate (x100 000) is 111 (95% CI 110–112), with a maximum of 160 in the age group 31–35 years. The geographical distribution of endometriosis incidence showed a very strong north-south spatial gradient. We consistently identified a group of five neighboring municipalities at higher risk (RR 1.31 95% CI 1.13; 1.52), even accounting for ascertainment bias. Conclusions: The cluster of 5 municipalities in the industrialized and polluted south-east part of the region is suggestive. However, due to the ecologic nature of the present study, information on the patients’ characteristics and exposure histories are limited. Individual studies, including biomonitoring, and life-course studies are necessary to better evaluate our findings.
Delineation of the Urban-Rural Boundary through Data Fusion: Applications to Improve Urban and Rural Environments and Promote Intensive and Healthy Urban Development
Authors: Zhang Jun , Yuan Xiaodie , Tan Xueping , Zhang Xue
Published: July 2021

As one of the most important methods for limiting urban sprawl, the accurate delineation of the urban–rural boundary not only promotes the intensive use of urban resources, but also helps to alleviate the urban issues caused by urban sprawl, realizing the intensive and healthy development of urban cities. Previous studies on delineating urban–rural boundaries were only based on the level of urban and rural development reflected by night-time light (NTL) data, ignoring the differences in the spatial development between urban and rural areas; so, the comprehensive consideration of NTL and point of interest (POI) data can help improve the accuracy of urban–rural boundary delineation. In this study, the NTL and POI data were fused using wavelet transform, and then the urban–rural boundary before and after data fusion was delineated by multiresolution segmentation. Finally, the delineation results were verified. The verification result shows that the accuracy of delineating the urban–rural boundary using only NTL data is 84.20%, and the Kappa value is 0.6549; the accuracy using the fusion of NTL and POI data on the basis of wavelet transform is 93.2%, and the Kappa value is 0.8132. Therefore, we concluded that the proposed method of using wavelet transform to fuse NTL and POI data considers the differences between urban and rural development, which significantly improves the accuracy of the delineation of urban–rural boundaries. Accurate delineation of urban–rural boundaries is helpful for optimizing internal spatial structure in both urban and rural areas, alleviating environmental problems resulting from urban development, assisting the formulation of development policies for urban and rural fringes, and promoting the intensive and healthy development of urban areas.
Family Medicine Academic Workforce of Medical Schools in Taiwan: A Nationwide Survey
Authors: Chen Shu-Han , Chang Hsiao-Ting , Lin Ming-Hwai , Chen Tzeng-Ji , Hwang Shinn-Jang , Lin Ming-Nan
Published: July 2021

Little is known about family medicine academic workforce in Taiwan, and basic data on this may aid healthcare decision-makers and contribute to the limited literature. We analyzed data from 13 medical schools in Taiwan collected by the Taiwan Association of Family Medicine from June to September 2019, regarding characteristics of medical schools, and total staff, gender, age, degree, working title (adjunct/full-time), academic level, and subspecialty of each current family medicine faculty member. Total 13 medical schools in Taiwan with an undergraduate education program in family medicine, but only nine of the 13 medical schools had family medicine departments, while four still do not. A total of 116 family medicine faculty members ranging from 33–69 years. Of these, most were male (n = 85, 73.3%), with a mean age of 43.3 years. Most faculty members possessed a master’s degree (n = 49, 42.2%), were academic lecturers (n = 49, 42.2%), were located in northern Taiwan (n = 79, 68.1%), and subspecialize in gerontology and geriatrics (n = 55, 47.4%) and hospice palliative care (n = 53, 45.7%). Additionally, most family medicine faculty in medical schools were adjunct faculty (n = 90, 77.6%), with only about one-fourth (n = 26, 22.4%) working full-time. Our study provides the most holistic census to date on academic family medicine faculty from all medical schools in Taiwan. The novel information can provide educational leaders, health policy managers, and decision-makers about the current developments of the family medicine departments in Taiwan’s medical schools. The basic data will help formulate an effective medical school family medicine education plan and improve the establishment and development of the family medicine faculty workforce to help medical education and national health policy development in the future in Taiwan.
Understanding the Spatial Effects of Unaffordable Housing Using the Commuting Patterns of Workers in the New Zealand Integrated Data Infrastructure
Authors: Xiong Chuyi , Cheung Ka Shing , Filippova Olga
Published: July 2021

Commuting behaviour has been intensively examined by geographers, urban planners, and transportation researchers, but little is known about how commuting behaviour is spatially linked with the job and housing markets in urban cities. New Zealand has been recognised as one of the countries having the most unaffordable housing over the past decade. A group of middle-class professionals called ‘key workers’, also known during the pandemic as ‘essential workers’, provide essential services for the community, but cannot afford to live near their workplaces due to a lack of affordable housing. As a result, these key workers incur significant sub-optimal commuting. Such job-housing imbalance has contributed to a so-called spatial mismatch problem. This study aims to visualise the excess commuting patterns of individual workers using the Integrated Data Infrastructure (IDI) from Statistics New Zealand. The visualisation suggests that over the last demi-decade, housing unaffordability has partially distorted the commuting patterns of key workers in Auckland. More of the working population, in particular those key workers, are displaced to the outer rings of the city. While there is an overall reduction in excess commuting across three groups of workers, key workers remain the working population with a disproportionate long excess commute.
Small-Molecule Therapeutic Perspectives for the Treatment of Progeria
Authors: Macicior Jon , Marcos-Ramiro Beatriz , Ortega-Gutiérrez Silvia
Published: July 2021

Hutchinson–Gilford progeria syndrome (HGPS), or progeria, is an extremely rare disorder that belongs to the class of laminopathies, diseases characterized by alterations in the genes that encode for the lamin proteins or for their associated interacting proteins. In particular, progeria is caused by a point mutation in the gene that codifies for the lamin A gene. This mutation ultimately leads to the biosynthesis of a mutated version of lamin A called progerin, which accumulates abnormally in the nuclear lamina. This accumulation elicits several alterations at the nuclear, cellular, and tissue levels that are phenotypically reflected in a systemic disorder with important alterations, mainly in the cardiovascular system, bones, skin, and overall growth, which results in premature death at an average age of 14.5 years. In 2020, lonafarnib became the first (and only) FDA approved drug for treating progeria. In this context, the present review focuses on the different therapeutic strategies currently under development, with special attention to the new small molecules described in recent years, which may represent the upcoming first-in-class drugs with new mechanisms of action endowed with effectiveness not only to treat but also to cure progeria.
Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors Reduce Platelet Activation Modulating ox-LDL Pathways
Authors: Cammisotto Vittoria , Baratta Francesco , Castellani Valentina , Bartimoccia Simona , Nocella Cristina , D’Erasmo Laura , Cocomello Nicholas , Barale Cristina , Scicali Roberto , Di Pino Antonino , Piro Salvatore , Del Ben Maria , Arca Marcello , Russo Isabella , Purrello Francesco , Carnevale Roberto , Violi Francesco , Pastori Daniele , Pignatelli Pasquale
Published: July 2021

Background: Proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) lower LDL-cholesterol and slow atherosclerosis preventing cardiovascular events. While it is known that circulating PCSK9 enhances platelet activation (PA) and that PCSK9i reduce it, the underlying mechanism is not still clarified. Methods: In a multicenter before–after study in 80 heterozygous familial hypercholesterolemia (HeFH) patients on treatment with maximum tolerated statin dose ± ezetimibe, PA, soluble-NOX2-derived peptide (sNOX2-dp), and oxidized-LDL (ox-LDL) were measured before and after six months of PCSK9i treatment. In vitro study investigates the effects of plasma from HeFH patients before and after PCK9i on PA in washed platelets (wPLTs) from healthy subjects. Results: Compared to baseline, PCSK9i reduced the serum levels of LDL-c, ox-LDL, Thromboxane (Tx) B2, sNOX2-dp, and PCSK9 (p < 0.001). The decrease of TxB2 correlates with that of ox-LDL, while ox-LDL reduction correlated with PCSK9 and sNOX2-dp delta. In vitro study demonstrated that wPLTs resuspended in plasma from HeFH after PCSK9i treatment induced lower PA and sNOX2-dp release than those obtained using plasma before PCSK9i treatment. This reduction was vanished by adding ox-LDL. ox-LDL-induced PA was blunted by CD36, LOX1, and NOX2 inhibition. Conclusions: PCSK9i treatment reduces PA modulating NOX2 activity and in turn ox-LDL formation in HeFH patients.
The Potential Role of REG Family Proteins in Inflammatory and Inflammation-Associated Diseases of the Gastrointestinal Tract
Authors: Sun Chao , Wang Xiaoyu , Hui Yangyang , Fukui Hirokazu , Wang Bangmao , Miwa Hiroto
Published: July 2021

Regenerating gene (REG) family proteins serve as multifunctional secretory molecules with trophic, antiapoptotic, anti-inflammatory, antimicrobial and probably immuno-regulatory effects. Since their discovery, accumulating evidence has clarified the potential roles of the REG family in the occurrence, progression and development of a wide range of inflammatory and inflammation-associated diseases of the gastrointestinal (GI) tract. However, significant gaps still exist due to the undefined nature of certain receptors, regulatory signaling pathways and possible interactions among distinct Reg members. In this narrative review, we first describe the structural features, distribution pattern and purported regulatory mechanisms of REG family proteins. Furthermore, we summarize the established and proposed roles of REG proteins in the pathogenesis of various inflammation-associated pathologies of the GI tract and the body as a whole, focusing particularly on carcinogenesis in the ulcerative colitis—colitic cancer sequence and gastric cancer. Finally, the clinical relevance of REG products in the context of diagnosis, treatment and prognostication are also discussed in detail. The current evidence suggests a need to better understanding the versatile roles of Reg family proteins in the pathogenesis of inflammatory-associated diseases, and their broadened future usage as therapeutic targets and prognostic biomarkers is anticipated.
The Role of ApoE Expression and Variability of Its Glycosylation in Human Reproductive Health in the Light of Current Information
Authors: Kacperczyk Monika , Kmieciak Agnieszka , Kratz Ewa Maria
Published: July 2021

Apolipoprotein E (ApoE), a 34-kDa glycoprotein, as part of the high-density lipoprotein (HDL), has antioxidant, anti-inflammatory and antiatherogenic properties. The variability of ApoE expression in the course of some female fertility disorders (endometriosis, POCS), and other gynecological pathologies such as breast cancer, choriocarcinoma, endometrial adenocarcinoma/hyperplasia and ovarian cancer confirm the multidirectional biological function of ApoE, but the mechanisms of its action are not fully understood. It is also worth taking a closer look at the associations between ApoE expression, the type of its genotype and male fertility disorders. Another important issue is the variability of ApoE glycosylation. It is documented that the profile and degree of ApoE glycosylation varies depending on where it occurs, the type of body fluid and the place of its synthesis in the human body. Alterations in ApoE glycosylation have been observed in the course of diseases such as preeclampsia or breast cancer, but little is known about the characteristics of ApoE glycans analyzed in human seminal and blood serum/plasma in the context of male reproductive health. A deeper analysis of ApoE glycosylation in the context of female and male fertility will both enable us to broaden our knowledge of the biochemical and cellular mechanisms in which glycans participate, having a direct or indirect relationship with the fertilization process, and also give us a chance of contributing to the enrichment of the diagnostic panel in infertile women and men, which is particularly important in procedures involved in assisted reproductive techniques. Moreover, understanding the mechanisms of glycoprotein glycosylation related to the course of various diseases and conditions, including infertility, and the interactions between glycans and their specific ligands may provide us with an opportunity to interfere with their course and thus develop new therapeutic strategies. This brief overview details some of the recent advances, mainly from the last decade, in understanding the associations between ApoE expression and some female and male fertility problems, as well as selected female gynecological diseases and male reproductive tract disorders. We were also interested in how ApoE glycosylation changes influence biological processes in the human body, with special attention to human fertility.
Postural Control and Sleep Quality in Cognitive Dual Tasking in Healthy Young Adults
Authors: Saraiva Marina , Marouvo Joel , Fernandes Orlando , Castro Maria António , Vilas-Boas João Paulo
Published: July 2021

Although sleep quality disorders can have a negative effect on postural control, studies about this subject are scarce. The aim of this study is to assess the differences in standing posture performance during dual tasking between healthy young adults with a good and poor sleep quality. Thirty-five healthy participants (23.09 ± 3.97 years) performed a postural task (standing posture single task ((ST)) and a dual task (DT): quiet standing while performing a concurrent cognitive task, while the total excursion of the center of pressure (TOTEX CoP), the displacement anterior–posterior (CoP-AP) and medial–lateral (CoP-ML), the mean total velocity displacement of CoP (MVELO CoP) and ellipse sway area (CEA) were measured with a force plate. After assessing the sleep quality with the Pittsburgh Sleep Quality Index, they were divided into two groups (good ((n = 21)) and poor ((n = 14)) sleep quality) to establish comparisons. This study revealed no significant differences in TOTEX CoP, CoP-ML, CoP-AP, MVELO CoP, and CEA among both sleep quality groups. In conclusion, differences in the sleep quality (good or poor sleep quality) among young adults appear not to be a relevant factor in the CoP variation, but the DT versus ST can compromise postural control performance independently of the sleep quality.
Urinary Cytokines Reflect Renal Inflammation in Acute Tubulointerstitial Nephritis: A Multiplex Bead-Based Assay Assessment
Authors: Martinez Valenzuela Laura , Draibe Juliana , Bestard Oriol , Fulladosa Xavier , Gómez-Preciado Francisco , Antón Paula , Nadal Ernest , Jové Maria , Cruzado Josep Maria , Torras Juan
Published: July 2021

Background: Acute tubulointerstitial nephritis (ATIN) diagnosis lays on histological assessment through a kidney biopsy, given the absence of accurate non-invasive biomarkers. The aim of this study was to evaluate the accuracy of different urinary inflammation-related cytokines for the diagnostic of ATIN and its distinction from acute tubular necrosis (ATN). Methods: We included 33 patients (ATIN (n = 21), ATN (n = 12)), and 6 healthy controls (HC). We determined the urinary levels of 10 inflammation-related cytokines using a multiplex bead-based Luminex assay at the time of biopsy and after therapy, and registered main clinical, analytical and histological data. Results: At the time of biopsy, urinary levels of I-TAC/CXCL11, CXCL10, IL-6, TNFα and MCP-1 were significantly higher in ATIN compared to HC. A positive correlation between the extent of the tubulointerstitial cellular infiltrates in kidney biopsies and the urinary concentration of I-TAC/CXCL11, MIG/CXCL9, CXCL10, IL17, IFNα, MCP1 and EGF was observed. Notably, I-TAC/CXCL11, IL-6 and MCP-1 were significantly higher in ATIN than in ATN, with I-TAC/CXCL11 as the best discriminative classifier AUC (0.77, 95% CI 0.57–0.95, p = 0.02). A combinatory model of these three urinary cytokines increased the accuracy in the distinction of ATIN/ATN compared to the individual biomarkers. The best model resulted when combining the three cytokines with blood eosinophil and urinary leukocyte counts (LR = 9.76). Follow-up samples from 11ATIN patients showed a significant decrease in I-TAC/CXCL11, MIG/CXCL9 and CXCL10 levels. Conclusions: Urinary I-TAC/CXCL11, CXCL10, IL6 and MCP-1 levels accurately distinguish patients developing ATIN from ATN and healthy individuals and may serve as novel non-invasive biomarkers in this disease.
Effect of Mercerization/Alkali Surface Treatment of Natural Fibres and Their Utilization in Polymer Composites: Mechanical and Morphological Studies
Authors: Verma Deepak , Goh Kheng Lim
Published: July 2021

Environmental pollution, such as air, water, and soil pollution, has become the most serious issue. Soil pollution is a major concern as it generally affects the lands and makes them non-fertile. The main cause of soil pollution is agro-waste. It may be possible to mitigate the agro-waste pollution by re-utilizing this agro-waste, namely natural fibres (NFs), by blending into polymer-based material to reinforce the polymer composite. However, there are pros and cons to this approach. Consequently, the polymer composite materials fabricated using NFs are inferior to those polymer composites that are reinforced by, e.g., carbon or glass fibres from the mechanical properties’ perspectives. The limitations of utilizing natural fibres in polymer matrix are their high moisture absorption, resulting in high swelling rate and degradation, inferior resistance to fire and chemical, and inferior mechanical properties. In particular, the NF polymer composites exhibit inferior interfacial adhesion between the fibre and the matrix, which, if improved, ultimately overcome all the listed limitations and improve the mechanical properties of the developed composites. To improve the interfacial adhesion leading to the enhancement of the mechanical properties, optimum chemical treatment such as Alkalization/Mercerization of the fibres have been explored. This article discusses the Mercerization/Alkali surface treatment method for NFs and its effects on the fibres regarding the Mercerization/Alkali surface treatment method for NFs and its effect on the fibres regarding their utilization in the polymer composites, the morphological features, and mechanical properties of composites.
Effect of the Addition of Nitrogen through Shielding Gas on TIG Welds Made Homogenously and Heterogeneously on 300 Series Austenitic Stainless Steels
Authors: Kshirsagar Rohit , Jones Steve , Lawrence Jonathan , Kanfoud Jamil
Published: July 2021

Tungsten inert gas (TIG) welding of austenitic stainless steels is a critical process used in industries. Several properties of the welds must be controlled depending on the application. These properties, which include the geometrical, mechanical and microstructural features, can be modified through an appropriate composition of shielding gas. Researchers have studied the effects of the addition of nitrogen through the shielding gas; however, due to limited amount of experimental data, many of the interaction effects are not yet reported. In this study, welds were made homogeneously as well as heterogeneously with various concentrations of nitrogen added through the shielding gas. The gas compositions used were 99.99%Ar (pure), 2.5% N2 + Ar, 5% N2 + Ar and 10% N2 + Ar. Additionally, the welding process parameters were varied to understand different interaction effects between the shielding gas chemistry and the process variables such as filler wire feed rate, welding current, etc. Strong interactions were observed in the case of heterogeneous welds between the gas composition and the filler wire feed rate, with the penetration depth increasing by nearly 30% with the addition of 10% nitrogen in the shielding gas. The interactions were found to influence the bead geometry, which, in turn, had an effect on the mechanical properties as well as the fatigue life of the welds. A nearly 15% increase in the tensile strength of the samples was observed when using 10% nitrogen in the shielding gas, which also translated to a similar increase in the fatigue life.
Improvement of the Ship Emergency Response Procedure in Case of Collision Accident Considering Crack Propagation during Salvage Period
Authors: Gledić Ivana , Mikulić Antonio , Parunov Joško
Published: July 2021

Specialized procedures to help in the emergency response situations following ship accidents have been under development by the Classification Societies. Such procedures consider the hull-girder collapse as the most important failure mode, without the possibility of crack propagation caused by fluctuating wave loads. In the present study, the fatigue crack propagation in the main deck of the oil tanker damaged in collision during salvage is investigated. The shape and size of the damage are modelled using the realistic bow shape of the striking ship and historical data of ship accidents. The stress intensity factor (SIF) across the main deck of the struck ship is calculated numerically and by the method based on the available experimental results of the crack propagation in the stiffened panel. Fluctuating wave–induced stresses in short-term sea conditions during salvage are obtained by Monte Carlo simulation (MC) based on Rayleigh distribution. Cycle-by-cycle crack propagation is calculated using Paris law. Many salvage simulations are performed to cover different possible time-histories of the fatigue loading. Results of the analysis are presented as histogram of the crack increase during salvage. Parametric analysis is performed to investigate the influence of the sea state severity, initial crack size, and towing duration on the final crack size. The proposed procedure can be considered as a part of a software tool for emergency response action during salvage of damaged ship.
Energy-Efficient Collision Avoidance MAC Protocols for Underwater Sensor Networks: Survey and Challenges
Authors: Alfouzan Faisal Abdulaziz
Published: July 2021

The Medium Access Control (MAC) layer protocol is the most important part of any network, and is considered to be a fundamental protocol that aids in enhancing the performance of networks and communications. However, the MAC protocol’s design for underwater sensor networks (UWSNs) has introduced various challenges. This is due to long underwater acoustic propagation delay, high mobility, low available bandwidth, and high error probability. These unique acoustic channel characteristics make contention-based MAC protocols significantly more expensive than other protocol contentions. Therefore, re-transmission and collisions should effectively be managed at the MAC layer to decrease the energy cost and to enhance the network’s throughput. Consequently, handshake-based and random access-based MAC protocols do not perform as efficiently as their achieved performance in terrestrial networks. To tackle this complicated problem, this paper surveys the current collision-free MAC protocols proposed in the literature for UWSNs. We first review the unique characteristic of underwater sensor networks and its negative impact on the MAC layer. It is then followed by a discussion about the problem definition, challenges, and features associated with the design of MAC protocols in UWANs. Afterwards, currently available collision-free MAC design strategies in UWSNs are classified and investigated. The advantages and disadvantages of each design strategy along with the recent advances are then presented. Finally, we present a qualitative comparison of these strategies and also discuss some possible future directions.
Journalism Innovation Labs 2.0 in Media Organisations: A Motor for Transformation and Constant Learning
Authors: Hogh-Janovsky Isabell , Meier Klaus
Published: July 2021

Media organisations and their newsrooms are not structurally equipped to adapt to the dynamic transformation that is increasingly demanded of them. To change this, ten years ago, growing numbers of media organisations began founding journalism innovation labs within their operations. More recently, a new generation of innovation lab has come about that builds on the experiences of the first labs. This paper examines—on the basis of organisational culture and innovation culture as theoretical framework—how journalism innovation labs 2.0 in media organisations are organised and which learnings the lab members have made compared with the pioneers of the first generation. The explorative study focused on five labs in Germany. In some phases of the innovation process the new labs benefited from the pioneering work of the predecessor labs. However, changes in the lab organisation became apparent. A developmental leap is reflected in the manifold efforts of the lab employees not to stay in their laboratory environment but instead to act as an innovation motor for the transformation of their media organisation by knowledge transfer, sharing of new ideas and approaches through advanced training, comprehensive and transparent innovation communication, agile project accompaniment, and personnel rotation. The innovation labs 2.0 apply a process of constant learning and dynamic change.
How to Prevent Peritoneal Dialysis Catheter Tip Migration: A Japanese Perspective
Authors: Ito Minoru , Koshika Masataka
Published: July 2021

The prevention of peritoneal dialysis (PD) catheter complications is essential to achieve a successful outcome. In recent years, nephrologists have performed more PD catheter insertion surgeries in Japan. The prevention of catheter complications is crucial for nephrologists who do not have all-around surgical skills. PD catheter tip migration is a common complication and a significant cause of catheter malfunction. Several preventive techniques have been reported for the PD catheter tip migration. This perspective described the following: (1) surgical technique in laparotomy, (2) laparoscopic surgery, (3) peritoneal wall anchor technique, and (4) catheter type selection. We hope that more effective methods of preventing catheter complications will be developed to ensure the success of PD treatment.
Identifying Potential Cropland Losses When Conserving 30% and 50% Earth with Different Approaches and Spatial Scales
Authors: Zhao Jianqiao , Cao Yue , Yu Le , Liu Xiaoxuan , Shi Yichuan , Liu Xiaoping , Yang Rui , Gong Peng
Published: July 2021

Biodiversity conservation is the cornerstone for sustainable development. Bold conservation targets provide the last opportunities to halt the human-driven mass extinction. Recently, bold conservation targets have been proposed to protect 30% or 50% of Earth. However, little is known about its potential impacts on cropland. We identify potential cropland losses when 30% and 50% of global terrestrial area is given back to nature by 2030/2050, at three spatial scales (global, biome and country) and using two approaches (“nature-only landscapes” and “shared landscapes”). We find that different targets, applied scales and approaches will lead to different cropland losses: (1) At the global scale, it is possible to protect 50% of the Earth while having minimum cropland losses. (2) At biome scale, 0.64% and 8.54% cropland will be lost globally in 2030 and 2050 under the nature-only approach while by contrast, the shared approach substantially reduces the number of countries confronted by cropland losses, demanding only 0% and 2.59% of global cropland losses in 2030 and 2050. (3) At the national scale, the nature-only approach causes losses of 3.58% and 10.73% of global cropland in 2030 and 2050, while the shared approach requires 0.77% and 7.55% cropland in 2030 and 2050. Our results indicate that bold conservation targets could be considered, especially when adopting the shared approach, and we suggest adopting ambitious targets (protecting at least 30% by 2030) at the UN Biodiversity Conference (COP 15) to ensure a sustainable future for Earth.
Factors Influencing the Project Duration of Urban Village Redevelopment in Contemporary China
Authors: Yuan Dinghuan , Yau Yung , Hou Huiying , Liu Yongshen
Published: July 2021

Project duration is one of the methods to measure the efficiency of project implementation. This study identifies the factors influencing the project duration of urban village redevelopment projects (UVRPs) in China. Based on the theory of new institutional economics and behavioral economics, this study develops three hypotheses regarding the causal relationship between institutional arrangement and project duration. Statistical analysis of data on 439 UVRPs collected from seven Chinese cities revealed that projects implemented through top-down institutional arrangements were more likely to take a long time than those implemented through bottom-up institutional arrangements. Projects implemented through top-down and government funding were more efficient than those implemented through top-down and villager funding. For bottom-up projects, there was no conclusion about whether village funding or private developer funding led to shorter project duration. Other determinants, including city, project attributes and initiation year, number of households involved, size of temporary relocation fee, and methods of selecting relocated housing, calculating temporary relocation fee and calculating relocation area influenced project duration.
Bowel Ultrasound in Inflammatory Bowel Disease: How Far in the Grayscale?
Authors: Furfaro Federica , Dal Buono Arianna , Allocca Mariangela , D'Amico Ferdinando , Zilli Alessandra , Gabbiadini Roberto , Danese Silvio
Published: July 2021

Bowel ultrasound (BUS) is a non-invasive and accurate technique for assessing activity, extension of disease, and complications in inflammatory bowel diseases. The main advantages of BUS are its safety, reproducibility, and low costs. Ancillary technologies of BUS (i.e., color Doppler and wave elastography) could broaden the diagnostic power of BUS, allowing one to distinguish between inflammation and fibrosis. Considering the costs and invasiveness of colonoscopy and magnetic resonance, BUS appears as a fast, safe, and accurate technique. The objective measures of disease allow one to make clinical decisions, such as optimization, switch, or swap of therapy. Previous studies reported a sensitivity and a specificity of more than 90% compared to endoscopy and magnetic resonance. Lastly, transperineal ultrasound (TPUS) is a promising approach for the evaluation of perianal disease in Crohn’s disease (CD) and disease activity in patients with ulcerative proctitis or pouchitis. Bowel ultrasound is being incorporated in the algorithm of managing inflammatory bowel diseases. Transmural healing evaluated through ultrasonography is emerging as a complementary target for disease treatment. In this review, we aimed to summarize and discuss the current evidence on BUS in the management of inflammatory bowel diseases and to address the challenges of a full validation of this technique.
A Retrospective Experience of Helicobacter pylori Histology in a Large Sample of Subjects in Northern Italy
Authors: Ribaldone Davide Giuseppe , Zurlo Carlo , Fagoonee Sharmila , Rosso Chiara , Armandi Angelo , Caviglia Gian Paolo , Saracco Giorgio Maria , Pellicano Rinaldo
Published: July 2021

Updated data about the prevalence of Helicobacter pylori (H. pylori) and its correlation with histological results are scarce. The aim of our study was to provide current data on the impact of H. pylori in a third-level endoscopy service. We performed a large, retrospective study analyzing the results of all histological samples of gastroscopy from the year 2019. In total, 1512 subjects were included. The prevalence of H. pylori was 16.8%. A significant difference between the prevalence in subjects born in Italy and those from eastern Europe, south America, or Africa was found (p < 0.0001, p = 0.006, and p = 0.0006, respectively). An association was found between H. pylori and active superficial gastritis (p < 0.0001). Current H. pylori and/or a previous finding of H. pylori was related to antral atrophy (p < 0.0001). Fifteen patients had low-grade dysplasia. There were no statistically significant associations with current or past H. pylori infection. One patient presented gastric cardia adenocarcinoma with regular gastric mucosa. One patient, H. pylori positive, was diagnosed with gastric signet ring cell adenocarcinoma in a setting of diffuse atrophy, without metaplasia.. Our study provides updated, solid (biopsy diagnosis and large population) data on the prevalence of H. pylori infection in a representative region of southern Europe.
Study of Skin Barrier Function in Psoriasis: The Impact of Emollients
Authors: Maroto-Morales Daniel , Montero-Vilchez Trinidad , Arias-Santiago Salvador
Published: July 2021

Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier. Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective of this study is to evaluate the effect of Vaseline jelly and a water-based formula on epidermal barrier function in psoriatic patients. Thirty-one patients with plaque-type psoriasis and thirty-one gender and age-matched healthy controls were enrolled in the study. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity and the erythema index were measured using non-invasive tools before and after applying Vaseline jelly and a water-based formula. TEWL was higher in psoriatic plaques than uninvolved psoriatic skin (13.23 vs. 8.54 g·m−2·h−1; p < 0.001). SCH was lower in psoriatic plaques than uninvolved psoriatic skin and healthy skin (13.44 vs. 30.55 vs. 30.90 arbitrary units (AU), p < 0.001). In psoriatic plaques, TEWL decreased by 5.59 g·m−2·h−1 (p = 0.001) after applying Vaseline Jelly, while it increased by 3.60 g·m−2·h−1 (p = 0.006) after applying the water-based formula. SCH increased by 9.44 AU after applying the water-based formula (p = 0.003). The use of emollients may improve epidermal barrier function in psoriatic patients. TEWL is decreased by using Vaseline, and SCH is increased by using the water-based formula.
Disorders, Vulnerabilities and Resilience in the Supply Chain in Pandemic Times
Authors: Ferreira Catarina , Cardoso Catarina , Travassos Mariana , Paiva Mariana , Pestana Micaela , Lopes João M. , Oliveira Márcio
Published: July 2021

The economic and social environment caused by the COVID-19 pandemic has brought additional pressure on supply chains because they now have more pressure to develop and adapt to a context of economic constraint. Delays in the supply chain can bring consequences such as the lack of food products by retailers, transporters and manufacturers. Thus, this study aims to examine the supply chain during the COVID-19 pandemic in small- and medium-sized food companies in the central region of Portugal, identifying potential problems and pointing out the respective solutions. For this purpose, the study uses a qualitative methodology through semi-structured interviews. It was found that small and medium-sized enterprises (SMEs) do not have a codified supply chain and that generally, these companies have a minimal budget, which requires a constant search for new suppliers that represent a reduction in costs. Moreover, most of the companies surveyed faced unexpected challenges, such as a lack of alternative suppliers. The present paper is original because it studies the supply chain in SMEs in the food sector during the COVID-19 pandemic, and it allows the ascertainment of practical suggestions for these companies to improve, as well as contributing to the clarification of the literature on the supply chain in times of crisis such as the current COVID-19 pandemic.
In-Situ TEM Annealing Observation of Helium Bubble Evolution in Pre-Irradiated FeCoNiCrTi0.2 Alloys
Authors: He Huanhuan , Lin Zhiwei , Jiang Shengming , Hu Xiaotian , Zhang Jian , Huang Zijing
Published: July 2021

The FeCoNiCrTi0.2 high-entropy alloys fabricated by vacuum arc melting method, and the annealed pristine material, are face centered cubic structures with coherent γ’ precipitation. Samples were irradiated with 50 keV He+ ions to a fluence of 2 × 1016 ions/cm2 at 723 K, and an in situ annealing experiment was carried out to monitor the evolution of helium bubbles during heating to 823 and 923 K. The pristine structure of FeCoNiCrTi0.2 samples and the evolution of helium bubbles during in situ annealing were both characterized by transmission electron microscopy. The annealing temperature and annealing time affect the process of helium bubbles evolution and formation. Meanwhile, the grain boundaries act as sinks to accumulate helium bubbles. However, the precipitation phase seems have few effects on the helium bubble evolution, which may be due to the coherent interface and same structure of γ’ precipitation and matrix.