bluuebunny/crossref_metadata_2025 huggingface dataset:
Polysubstance use in a community sample of Black cisgender sexual minority men and transgender women in Chicago during initial COVID-19 pandemic peak
Authors: Moody Raymond L. , Chen Yen-Tyng , Schneider John A. , Knox Justin , Timmins Liadh , Hanson Hillary , Koli Kangkana , Durrell Mainza , Dehlin Jessica , Eavou Rebecca , Martins Silvia S. , Duncan Dustin T.
Published: January 2022

Background

In response to COVID-19, the city of Chicago issued stay-at-home orders, which began on March 20, 2020, and restrictions meant to “flatten the curve” remained in effect until June 2, 2020. On June 3, 2020, Chicago entered the reopening phase. This study compares rates of polysubstance use by COVID-19 lockdown phase and across sociodemographic characteristics in a Chicago-based sample of Black cisgender sexual minority men (SMM) and transgender women.

Method

Data come from the Neighborhood and Networks (N2) cohort, an ongoing study of Black cisgender SMM and transgender women living in Chicago. Participants (N = 226) completed a survey between April 20, 2020, and July 30, 2020, during the initial peak of the COVID-19 pandemic in Chicago. We conducted chi-square tests of independence and modified Poisson regression models with robust error variance and estimated adjusted prevalence ratios.

Results

Alcohol and marijuana were the most used substances, with 73.5% reporting at least one drinking day and 71.2% of the sample reporting marijuana use in the past 14 days. Tobacco was used by 41.6% of the sample, and illegal drug use, which does not include marijuana, was reported by 17.7% of the sample. Substance use was consistently associated with the use of other substances. As such, polysubstance use (i.e., using two or more substances) was common in this sample (63.7%). Few sociodemographic differences emerged, and substance use was not associated with lockdown phase.

Conclusion

Substance use, including polysubstance use, was high in our sample of Black SMM and transgender women during the initial peak of the COVID-19 pandemic. Continued monitoring is needed given the duration of the COVID-19 pandemic and the negative health consequences associated with substance use in this population.
Prognostic factors for medial open-wedge high tibial osteotomy with spacer implantation in patients with medial compartmental knee osteoarthritis
Authors: Wang Fengkun , Ma Wenru , Chen Jinli , Cong Wenbin , Zhang Yingze , Yu Tengbo , Zhang Yi
Published: January 2022

Background

To identify medial open-wedge high tibial osteotomy (MOWHTO) prognostic factors with wedge-shaped spacer implantation (spacer-type MOWHTO) for varus medial compartment knee osteoarthritis.

Methods

Patients who underwent spacer-type MOWHTO between August 2018 and September 2019 were prospectively enrolled in this study. Patients were divided into effective group and invalid group based on the Western Ontario and McMasters University Osteoarthritis Index (WOMAC) score one year postoperatively. The variables assessed at baseline and one year postoperatively including age, sex, body mass index (BMI), Kellgren–Lawrence (K–L) grade, hip–knee–ankle angle (HKAA), medial proximal tibial angle (MPTA), posterior tibial slope angle (PTSA), Blackburn–Peel index (BPI), duration of symptoms, and WOMAC score were compared. Prognostic factors were analyzed using logistic regression, and the corresponding odds ratios were also calculated.

Results

A total of 104 patients were enrolled in the study protocol at one year postoperatively. The WOMAC score decreased from 72.39 ± 12.95 at baseline to 20.06 ± 12.96 at one year postoperatively. Univariate analysis revealed that the significant predictors of the WOMAC score were age > 70 years, BMI > 30 kg/m2, K–L grade IV, and pre-HKAA > 10° (P < 0.1 for all). Multivariable logistic regression analysis revealed that age > 70 (OR = 4.861) and K–L grade IV (OR = 6.590) were significantly associated with the higher WOMAC score at one year postoperatively.

Conclusions

Spacer-type MOWHTO is an effective treatment for osteoarthritis with varus deformity. The prognostic factors for spacer-type MOWHTO are age and K–L grade.
UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients
Authors: Huang Jinfa , Wang Guilian , Liao Kedan , Xie Ning , Deng Kaixian
Published: January 2022

Background

The uncoupling proteins (UCPs) are critical genes associated with tumorigenesis and chemoresistance. However, little is known about the molecular mechanism of the UCPs in ovarian cancer (OV).

Material and methods

UCPs expression analysis was conducted using Gene Expression Profiling Interactive Analysis (GEPIA), and its potential in clinical prognosis was analyzed using Kaplan- Meier analyses. The influence of UCPs on immune infiltration was analyzed by TIMER. In addition, the correlation between UCPs expression and molecular mechanisms was investigated by TIMER and Cancer Single-cell State Atlas (CancerSEA).

Results

UCP1, UCP2, UCP3 and UCP5 expression levels correlated with a favorable prognosis and tumor progression. Moreover, UCP1 expression correlated to several immune cell markers and regulated tumorigenesis, such as tumor invasion, EMT, metastasis and DNA repair. In addition, UCP1 potentially involved in genes expression of SNAI2, MMP2, BRCA1 and PARP1.

Conclusions

These results implied a critical role of UCP1 in the prognosis and immune infiltration of ovarian cancer. In addition, UCP1 expression participated in regulating multiple oncogenes and tumorigenesis.
Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis
Authors: Pan Tingting , Sun Shaoqiong , Chen Yang , Tian Rui , Chen Erzhen , Tan Ruoming , Wang Xiaoli , Liu Zhaojun , Liu Jialin , Qu Hongping
Published: January 2022

Background

Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate cellular immunity and play vital roles in clearing pathogenic bacteria. However, the metabolic characteristics and immunomodulatory pathways of PMNs during sepsis have not been investigated. In the present study, we explored the immune metabolism characteristics of PMNs and the mechanism by which neutrophilic glycolysis is regulated during sepsis.

Methods

Metabolomics analysis was performed on PMNs isolated from 14 septic patients, 26 patients with acute appendicitis, and 19 healthy volunteers. Transcriptome analysis was performed on the PMNs isolated from the healthy volunteers and the patients with sepsis to assess glycolysis and investigate its mechanism. Lipopolysaccharide (LPS) was used to stimulate the neutrophils isolated from the healthy volunteers at different time intervals to build an LPS-tolerant model. Chemotaxis, phagocytosis, lactate production, oxygen consumption rate (OCR), and extracellular acidification rate (ECAR) were evaluated.

Results

Transcriptomics showed significant changes in glycolysis and the mTOR/HIF-1α signaling pathway during sepsis. Metabolomics revealed that the Warburg effect was significantly altered in the patients with sepsis. We discovered that glycolysis regulated PMNs’ chemotaxis and phagocytosis functions during sepsis. Lactate dehydrogenase A (LDHA) downregulation was a key factor in the inhibition of glycolysis in PMNs. This study confirmed that the PI3K/Akt-HIF-1α pathway was involved in the LDHA expression level and also influenced PMNs’ chemotaxis and phagocytosis functions.

Conclusions

The inhibition of glycolysis contributed to neutrophil immunosuppression during sepsis and might be controlled by PI3K/Akt-HIF-1α pathway-mediated LDHA downregulation. Our study provides a scientific theoretical basis for the management and treatment of patients with sepsis and promotes to identify therapeutic target for the improvement of immune function in sepsis.
Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients
Authors: Leistner Rasmus , Schroeter Lisa , Adam Thomas , Poddubnyy Denis , Stegemann Miriam , Siegmund Britta , Maechler Friederike , Geffers Christine , Schwab Frank , Gastmeier Petra , Treskatsch Sascha , Angermair Stefan , Schneider Thomas
Published: January 2022

Purpose

Corticosteroids, in particular dexamethasone, are one of the primary treatment options for critically ill COVID-19 patients. However, there are a growing number of cases that involve COVID-19-associated pulmonary aspergillosis (CAPA), and it is unclear whether dexamethasone represents a risk factor for CAPA. Our aim was to investigate a possible association of the recommended dexamethasone therapy with a risk of CAPA.

Methods

We performed a study based on a cohort of COVID-19 patients treated in 2020 in our 13 intensive care units at Charité Universitätsmedizin Berlin. We used ECMM/ISHM criteria for the CAPA diagnosis and performed univariate and multivariable analyses of clinical parameters to identify risk factors that could result in a diagnosis of CAPA.

Results

Altogether, among the n = 522 intensive care patients analyzed, n = 47 (9%) patients developed CAPA. CAPA patients had a higher simplified acute physiology score (SAPS) (64 vs. 53, p < 0.001) and higher levels of IL-6 (1,005 vs. 461, p < 0.008). They more often had severe acute respiratory distress syndrome (ARDS) (60% vs. 41%, p = 0.024), renal replacement therapy (60% vs. 41%, p = 0.024), and they were more likely to die (64% vs. 48%, p = 0.049). The multivariable analysis showed dexamethasone (OR 3.110, CI95 1.112–8.697) and SAPS (OR 1.063, CI95 1.028–1.098) to be independent risk factors for CAPA.

Conclusion

In our study, dexamethasone therapy as recommended for COVID-19 was associated with a significant three times increase in the risk of CAPA.

Trial registration

Registration number DRKS00024578, Date of registration March 3rd, 2021.
Simplifying and optimising management of acute malnutrition in children aged 6 to 59 months: study protocol for a 3 arms community-based individually randomised controlled trial in decentralised Niger
Authors: Daures Maguy , Hien Jérémie , Phelan Kevin , Boubacar Harouna , Atté Sanoussi , Aboubacar Mahamadou , Aly Ahmad A. G. M. , Mayoum Baweye , Azani Jean-Claude , Koffi Jean-Jacques , Séri Benjamin , Beuscart Aurélie , Gabillard Delphine , Hubert Victoire , Cazes Cécile , Kinda Moumouni , Anglaret Xavier , Kangas Suvi , Shepherd Susan , Becquet Renaud
Published: January 2022

Background

Simplified approaches of acute malnutrition (AM) treatment have been conducted over the past 5 years intending to unify processes and increase coverage among children aged 6 to 59 months without medical complication. The Optimsing treatment for Acute Malnutrition (OptiMA) and the Combined Protocol for Acute Malnutrition Study (ComPAS) are mid-upper arm circumference (MUAC)-based approaches treating children with MUAC < 125 mm or oedema with one sole product—ready-to-use therapeutic food—at a gradually tapered doses. This trial aims to compare the OptiMA and ComPAS strategies to the standard nutritional protocol of Niger assessed by a favourable outcome in the treatment of uncomplicated AM at 6 months post-randomisation and in terms of recovery rate after treatment of uncomplicated SAM (WHZ < − 3 or MUAC < 115mm or oedema) and among the most vulnerable children (MUAC < 115mm or oedema).

Methods

A non-inferiority individually randomised controlled clinical trial was conducted at the primary health centres level and in the community in the Zinder region in Niger in March 2021. Participants are children aged 6–59 months attending outpatient health centres with MUAC < 125mm or oedema without medical complications. All participants are followed for 6 months. Simplified strategies propose a gradual reduction of RUTF according to MUAC and weight in OptiMA and MUAC only in ComPAS. Favourable outcome is compositely defined at 6 months post-inclusion as being alive, not acutely malnourished by the definition applied at inclusion and without any additional episode of AM throughout the 6-month observation period. Recovery is defined throughout the 6 months post-randomisation by a minimum of 4-week duration of treatment, an axillary temperature < 37.5°C, an absence of bipedal oedema and a MUAC ≥ 125 mm for two consecutive weeks. The sample size calculation required 567 children per arm for the main objective, 295 and 384 children per arm for the secondary objectives among SAM and MUAC < 115 mm children, respectively. Per-protocol and intention-to-treat analyses will be conducted for each outcome.

Discussion

This trial is intending to generate much-needed evidence on various simplified and optimised AM treatment approaches and to participate in reaching a consensus on such nutrition protocols.

Trial registration

ClinicalTrials.govNCT04698070. Registered on January 6, 2021
Are realist randomised controlled trials possible? A reflection on the INCLUSIVE evaluation of a whole-school, bullying-prevention intervention
Authors: Warren Emily A. , Melendez-Torres G. J. , Bonell Chris
Published: January 2022

We previously proposed that realist randomised controlled trials could be used to evaluate how, for whom and under what conditions complex interventions can be used to activate mechanisms to improve health. While this idea was accepted by some, it was also met with resistance, particularly from some realist evaluators who believe that trials are inextricably positivist and dependent on constant conjunctions to understand causation, and that realist trials are unfeasible because participants and contexts will be insufficiently diverse to enable the testing of context-mechanism-outcome configurations. In this paper, we reflect on analyses of qualitative and quantitative data from the Initiating Change Locally in Bullying and Aggression through the School Environment (INCLSUIVE) trial, and whether these are useful and aligned with realism. We summarise the concerns expressed by realists and reflect on the philosophical and practical challenges that we encountered and whether or not they are related to the trial’s design. Finally, we reflect on the trial’s weaknesses and highlight areas that future researchers might consider when running realist trials. We conclude that realist randomised controlled trials are philosophically coherent, practically feasible, and can produce nuanced findings.
Acupuncture combined with traditional Chinese medicine e-aid cognitive behavioral therapy for insomnia (TCM-eCBT-I) for chronic insomnia: study protocol for a randomized controlled trial
Authors: Liu Cheng-yong , Zhao Ya-nan , Wang Xiao-qiu , Qin Shan , Wan Qing-yun , Zheng Shi-yu , Wu Wen-zhong
Published: January 2022

Introduction

The incidence of insomnia is getting higher and higher. Long-term insomnia seriously affects people’s health. Drug use is usually accompanied with adverse events. Both acupuncture and cognitive behavioral therapy for insomnia (CBT-I) have been proven to be safe and effective non-pharmacological treatments for insomnia. As the insomniacs’ bad sleep behavior and wrong cognition have not been effectively corrected, acupuncture has a quick effect, high patient compliance but unstable long-term efficacy, while CBT-I is complex, time-consuming, and expensive; additionally, patient compliance is low, and the number of trained therapists is limited, making it difficult to carry out. Therefore, this study aims to use the insomnia TCM system to construct a convenient and feasible traditional Chinese medicine e-aid cognitive behavioral therapy for insomnia (TCM-eCBT-I) for Chinese people, and combine the advantages of acupuncture and TCM-eCBT-I for maintaining long-term efficacy, and three treatments will be evaluated to provide clinicians with a more effective clinical protocol

Methods and analysis

This study is a single-center, open-label, randomized controlled trial. Ninety subjects will be recruited and randomly assigned to three groups: the acupuncture group, the TCM-eCBT-I group, and the acupuncture combined with TCM-eCBT-I group, in a ratio of 1:1:1. We will evaluate the Pittsburgh Sleep Quality Index (PSQI) and Dysfunctional Beliefs and Attitudes About Sleep Scale (DBAS), Insomnia Severity Index (ISI), sleep diary, Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and Fatigue Scale-14 Scale (FS-14) scales. All adverse reactions will be assessed through the ADVERSE event table. All outcomes will be evaluated online at 0 weeks, 4 weeks, 8 weeks, 16 weeks, and 28weeks.

Ethics and dissemination

This study has been approved by the Institutional Review Board of the Affiliated Hospital of Nanjing University of Chinese Medicine (2020 NL-018-02). Informed consent will be obtained from all the subjects. The results will be shared with sleep researchers, public, and relevant academic institutions through high-impact peer-reviewed publications.

Trial registration

Chinese Clinical Trial Registry ChiCTR2000032960. Registered on 17 May 2020
CDKAL1 gene rs7756992 A/G and rs7754840 G/C polymorphisms are associated with gestational diabetes mellitus in a sample of Bangladeshi population: implication for future T2DM prophylaxis
Authors: Amin U. S. Mahzabin , Parvez Nahid , Rahman Tahia Anan , Hasan Md. Rakibul , Das Keshob Chandra , Jahan Sharmin , Hasanat Muhammad Abul , Seraj Zeba I. , Salimullah Md.
Published: January 2022

Background

Association of single nucleotide polymorphisms (SNP) rs7756992 A/G and rs7754840 G/C of cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene with the susceptibility of gestational diabetes mellitus (GDM) has been studied in a group of Bangladeshi women.

Methods

In this case–control study, 212 GDM patients and 256 control subjects were genotyped for rs7756992 and rs7754840 by PCR-RFLP and TaqMan™ allelic discrimination assay method respectively. Genotyping results were confirmed by DNA sequencing and replicated TaqMan™ assay. The odds ratios and their 95% confidence interval were calculated by logistic regression to determine the associations between genotypes and GDM.

Results

The genotype frequencies of rs7756992-AA/AG/GG in the GDM group and the control group were 37%/48%, 53%/45%, 10%/7% and those of rs7754840-CC/CG/GG were 51%/55%, 40.1%/39.8%, 9%/5% respectively. Under dominant and log additive models rs7756992 was revealed significantly associated with GDM after being adjusted for family history of diabetes (FHD) and gravidity. Conversely, rs7754840 was significantly associated (P = 0.047) with GDM only under the recessive model after the same adjustment. The risk allele frequency of both SNPs was higher in the GDM group but significantly (P = 0.029) increased prevalence was observed in the rs7756992 G allele. When positive FHD and risk alleles of these SNPs were synergistically present in any pregnant woman, the chance of developing GDM was augmented by many folds. The codominant model revealed 2.5 and 2.1 folds increase in odds by AG (rs7756992) and GC (rs7754840) genotypes and 3.7 and 4.5 folds by GG (rs7756992) and CC (rs7754840) genotypes respectively. A significant 2.7 folds (P = 0.038) increase in odds of GDM resulted from the interaction of rs7756992 and family history of diabetes under the dominant model. The cumulative effect of multigravidity and risk alleles of these SNPs increased the odds of GDM more than 1.5 folds in different genotypes.

Conclusion

This study not only revealed a significant association between rs7756992 and rs7754840 with GDM but also provided the possibility as potential markers for foretelling about GDM and type 2 diabetes mellitus in Bangladeshi women.
Phenotype of higher post-load insulin response as a predictor of all-cause mortality and cardiovascular mortality in the Chinese non-diabetic population
Authors: Shen Xiaoxia , He Siyao , Wang Jinping , Qian Xin , Wang Hui , Zhang Bo , Chen Yanyan , Li Hui , Li Guangwei
Published: January 2022

Aim

This study aimed to assess whether a higher insulin response increased the long-term risk of mortality in a non-diabetic population.

Methods

A total of 446 people with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT) who participated in the Da Qing Diabetes Study, were stratified into quartiles subgroups according to their baseline insulin area under the curve (AUC) during oral glucose tolerance test, defined as Q1, Q2, Q3 and Q4. The participants were followed from 1986 to 2016 to assess the risk of death in association with the magnitude of post-load insulin response.

Results

Over 30 years, the rates of all cause death were 9.94, 14.81, 15.02, and 17.58 per 1000 person-years across the four groups respectively. The rate for cardiovascular disease (CVD) death was 5.14, 6.50, 6.80 and 10.47 per 1000 person-years. Compared with Q1, the risk of all-cause death was significantly higher in participants in Q4 (HR = 2.14, 95% CI 1.34–3.42), Q3 (HR = 1.94, 95% CI 1.20–3.14), and Q2 group (HR = 1.70, 95% CI 1.06–2.74). In the Fine-Gray model with non-CVD death as competing risk, the increased insulin AUC were also significantly associated with the CVD death (Q4 vs Q1, HR = 2.04, 95% CI 1.10–3.79). In the fractional polynomial regression analysis, a nonlinear association between insulin AUC and all-cause and CVD death was demonstrated. In addition, insulin AUC was associated with a progressively higher risk of all-cause death and CVD death (fractional power 3, P < 0.001).

Conclusion

A higher post-load insulin response was significantly associated with a long-term increased risk of all-cause and CVD deaths in the Chinese non-diabetic population. It suggests that people featured by this phenotype is a potential important target for further intervention.
Transcriptome analysis of Echinococcus granulosus sensu stricto protoscoleces reveals differences in immune modulation gene expression between cysts found in cattle and sheep
Authors: Pereira Ismael , Hidalgo Christian , Stoore Caroll , Baquedano María Soledad , Cabezas Carolina , Bastías Macarena , Riveros Aníbal , Meneses Claudio , Cancela Martín , Ferreira Henrique Bunselmeyer , Sáenz Leonardo , Paredes Rodolfo
Published: January 2022

Cystic Echinococcosis (CE), a zoonotic parasitic disease, is caused by the cestode Echinococcus granulosus sensu lato. CE inflicts severe damage in cattle, sheep, and human hosts worldwide. Fertile CE cysts are characterized by the presence of viable protoscoleces. These parasite forms are studied with minimal contamination with host molecules. Hosts, cattle and sheep, show differences in their CE cyst fertility. The effect of the host in protoscolex transcriptome is not known. We genotyped and performed transcriptomic analysis on sheep protoscoleces obtained from liver and lung CE cysts. The transcriptomic data of Echinococcus granulosus sensu stricto protoscoleces from 6 lung CE cysts and 6 liver CE cysts were Collected. For host comparison analysis, 4 raw data files belonging to Echinococcus granulosus sensu stricto protoscoleces from cattle liver CE cysts were obtained from the NCBI SRA database. Principal component and differential expression analysis did not reveal any statistical differences between protoscoleces obtained from liver or lung cysts, either within the same sheep or different sheep hosts. Conversely, there are significant differences between cattle and sheep protoscolex samples. We found differential expression of immune-related genes. In cattle, 7 genes were upregulated in protoscoleces from liver cysts. In sheep, 3 genes were upregulated in protoscoleces from liver and lung CE cysts. Noteworthy, are the differential expression of antigen B, tegument antigen, and arginase-2 in samples obtained from sheep CE cysts, and basigin in samples from cattle CE cysts. These findings suggest that the host species is an important factor involved in the differential expression of immune related genes, which in turn is possibly related to the fertility of Echinococcus granulosus sensu stricto cysts.
Application of deterministic, stochastic, and hybrid methods for cloud provider selection
Authors: de Moraes Lucas Borges , Parpinelli Rafael Stubs , Fiorese Adriano
Published: January 2022

Cloud Computing popularization inspired the emergence of many new cloud service providers. The significant number of cloud providers available drives users to complex or even impractical choice of the most suitable one to satisfy his needs without automation. The Cloud Provider Selection (CPS) problem addresses that choice. Hence, this work presents a general approach for solving the CPS problem using as selection criteria performance indicators compliant with the Cloud Service Measurement Initiative Consortium - Service Measurement Index framework (CSMIC-SMI). To accomplish that, deterministic (CPS-Matching and CPS-DEA), stochastic (Evolutionary Algorithms: CPS-GA, CPS-BDE, and CPS-DDE), and hybrid (Matching-GA, Matching-BDE, and Matching-DDE) selection optimization methods are developed and employed. The evaluation uses a synthetic database created from several real cloud provider indicator values in experiments comprising scenarios with different user needs and several cloud providers indicating that the proposed approach is appropriate for solving the cloud provider selection problem, showing promising results for a large-scale application. Particularly, comparing which approach chooses the most appropriate cloud provider the better, the hybrid one presents better results, achieving the best average hit percentage, dealing with simple and multi-cloud user requests.
Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential
Authors: Gao Lina , Zhang Yun , Sterling Keenan , Song Weihong
Published: January 2022

Synaptic abnormalities are a cardinal feature of Alzheimer’s disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic link between amyloid β (Aβ) and tau pathology and thus may serve as an obligatory relay of the cognitive impairment in AD. Brain-derived neurotrophic factors (BDNFs) play an important role in maintaining synaptic plasticity in learning and memory. Considering AD as a synaptic disorder, BDNF has attracted increasing attention as a potential diagnostic biomarker and a therapeutical molecule for AD. Although depletion of BDNF has been linked with Aβ accumulation, tau phosphorylation, neuroinflammation and neuronal apoptosis, the exact mechanisms underlying the effect of impaired BDNF signaling on AD are still unknown. Here, we present an overview of how BDNF genomic structure is connected to factors that regulate BDNF signaling. We then discuss the role of BDNF in AD and the potential of BDNF-targeting therapeutics for AD.
Microstructure and Chloride Diffusion Properties of Hardened Fly Ash Cement Paste with Three-dimensional Graphene
Authors: Ying Jingwei , Xi Xiaoying
Published: January 2022

In this paper, the influence of three-dimensional graphene (3DG) on the microstructure and chloride diffusion properties of fly ash cement paste was investigated. 3DG accounting for 0.0–0.2% of cement mass was evenly dispersed in hardened cement paste containing fly ash by using ultrasonic and polycarboxylate superplasticizer. The microstructure of the cement paste was characterized by mercury intrusion test (MIP), X-ray diffraction (XRD), and scanning electron microscope (SEM). The results indicate that an appropriate amount of 3DG accelerates the secondary hydration of fly ash and provides a platform for the growth of cement hydration crystals. Moreover, the hydrated crystal fills the pores, reduces the harmful porosity, and refines the pore structure. The enhanced microstructure significantly improved mechanical properties and chloride diffusion resistance of hardened fly ash cement. With the addition of 0.1% 3DG, the compressive strength increased by 31.33%, and the chloride diffusion coefficient was reduced by 49.44%. The findings are beneficial to promote the generalized application of 3DG in cement in the marine environment.
Replicating or franchising a STEM afterschool program model: core elements of programmatic integrity
Authors: Stevenson Nikolaus , Sommers Amie S. , Grandgenett Neal , Tapprich William , McQuillan Julia , Phillips Michelle , Jensen Rachael , Cutucache Christine
Published: January 2022

Background

Designed in 2012 with a first implementation in 2013, NE STEM 4U is a professional development program for post-secondary students/undergraduates, and serves as a source of outreach, content knowledge generation, and STEM literacy for youth in grades kindergarten through 8th grade (ages 5–14). The model empowers post-secondary students as facilitators of inquiry-based learning within the context of an out-of-school time program. This study investigated the potential for replicating or ‘franchising’ this model by evaluating on the following: (1) Is the model replicable? And, if so, (2) what core elements are necessary for program fidelity? And (3) is there a dependency on a particular setting/participant type (e.g., a more rural or urban setting)?

Results

Strategic expansion of the program to different institutional types (i.e., Research 1, Research II, and a predominantly undergraduate institution), different geographical locations (i.e., rural and urban), and with various school district partners (i.e., large and small) determined that program fidelity and replicability required 4 core elements or criteria: (i) intentional programming, (ii) staff quality, (iii) effective partnerships, and (iv) program evaluation and continuous improvement. Importantly, we examined emergent themes by each site, as well as in combination (n = 16 focus group participants, n = 12 reflection surveys). These data indicated that Flexibility (21.22%), Student Engagement (i.e., Youth) (19.53%), Classroom Management (i.e., also pertaining to youth) (19.31%), and Communication (15.71%) were the themes most referenced by the post-secondary student mentors in the NE STEM 4U program, regardless of site. Finally, the YPQA results demonstrate general replication of program quality in a “franchise” location.

Conclusions

These results highlight the core elements of the NE STEM 4U program for consideration of expansion (through strategic replication or ‘franchising’) as a possible international model. The findings and voices highlight the program’s trajectory toward success into environments that expand professional development for post-secondary students, and for delivering STEM opportunities for youth.
Understanding STEM academics’ responses and resilience to educational reform of academic roles in higher education
Authors: Ross Pauline Mary , Scanes E. , Poronnik P. , Coates H. , Locke W.
Published: January 2022

Background

Across the globe, there have been significant reforms to improve STEM education at all levels. A significant part of this has been teacher reform. While the responses and resilience of STEM teachers to educational reforms in secondary education have received significant attention, the responses and resilience of STEM teachers in higher education remains understudied. In higher education, educational reforms of academic roles have seen increasing numbers of STEM academics focussed on education. Responses of STEM academics to education reform of the academic role have some parallels with teacher resilience, but there are also potential misalignments within a culture which values and prioritises science disciplinary research. This study examined the responses of STEM academics in higher education to educational reform of the academic role using the theoretical construct of resilience and Bronfenbrenner’s socio-ecological model. This was a 2-year case study of 32 academics and senior educational leaders in higher education in STEM. Data collection included semi-structured interviews which were theme coded and inductively analysed.

Results

The responses and resilience of STEM academics focussed on education appeared to be dependent on interactions between individual disposition in the microsystem and influences of the exosystem and the external macrosystem. Five major themes emerged about the value and quality, scholarship and expertise, progress and mobility, status and identity and community and culture of STEM academics focussed on education. The exosystem was a significant unidirectional influence on STEM academics where judgements were made concerning academic performance, awards, and promotion. Responses of senior leaders in the exosystem were influenced by the macrosystem and culture of science. Academics focussed on research, rather than education were more valued and more likely to be both financially rewarded and promoted.

Conclusion

During this pressured decade, where COVID-19 has intensified stress, more attention on the direction and reciprocal relationships in the socio-ecological model of higher education is needed in order for educational reform in higher education STEM to be effective. Resilience of STEM academics to educational reform in higher education is a dynamic quality, and the capacity to “bounce back”, learn from challenges, and realise expectations of educational reform will depend on an understanding of resilience and support of Bronfenbrenner’s spheres of influence.
Influence of noise manipulation on retention in a simulated ICU ward round: an experimental pilot study
Authors: Erne Katja , Knobel Samuel E. J. , Naef Aileen C. , Gerber Stephan M. , Fischer Tim , Mast Fred W. , Schefold Joerg C. , Zante Bjoern , Nef Tobias , Jeitziner Marie-Madlen
Published: January 2022

Background

Noise exposure leads to a reduction in cognitive abilities in diverse settings, however, only limited data exist examining the effects of environmental ICU noise on the cognitive performance of ICU professionals. A frequently occurring and demanding retention task in ICUs are ward rounds, which are considered key for the provision of medical care. Here, we investigate the influence of noise on information retention in a simulated ward round.

Methods

ICU professionals were exposed to a recorded, ICU ward round, simulated partly with and partly without environmental ICU noise. Ward rounds were followed by specific questions about previously provided information.

Results

56 ICU professionals (aged 26–59 years) were included. A logistic mixed model showed a reduction of 27% (P < 0.001) in the ward round test performance when participants were exposed to environmental ICU noise. Furthermore, advanced age was associated with reduced retention (− 28%, P < 0.001), questions containing important information performed better (+ 36%, P < 0.001), and higher stress led to better performance in retention (+ 24%, P = 0.01).

Conclusions

Our data showed a considerable negative influence of environmental ICU noise during a simulated ward round. Therefore, reduction of environmental ICU noise is recommended. The influence of additional factors, including stress, priorities, and demographic factors should be pursued in subsequent investigations.
Biotechnological advances for improving natural pigment production: a state-of-the-art review
Authors: Lyu Xiaomei , Lyu Yan , Yu Hongwei , Chen WeiNing , Ye Lidan , Yang Ruijin
Published: January 2022

In current years, natural pigments are facing a fast-growing global market due to the increase of people’s awareness of health and the discovery of novel pharmacological effects of various natural pigments, e.g., carotenoids, flavonoids, and curcuminoids. However, the traditional production approaches are source-dependent and generally subject to the low contents of target pigment compounds. In order to scale-up industrial production, many efforts have been devoted to increasing pigment production from natural producers, via development of both in vitro plant cell/tissue culture systems, as well as optimization of microbial cultivation approaches. Moreover, synthetic biology has opened the door for heterologous biosynthesis of pigments via design and re-construction of novel biological modules as well as biological systems in bio-platforms. In this review, the innovative methods and strategies for optimization and engineering of both native and heterologous producers of natural pigments are comprehensively summarized. Current progress in the production of several representative high-value natural pigments is also presented; and the remaining challenges and future perspectives are discussed.

Graphical Abstract
Rapid, accurate computation of narrow-band sky radiance in the 940 nm gas absorption region using the correlated k-distribution method for sun-photometer observations
Authors: Momoi Masahiro , Irie Hitoshi , Sekiguchi Miho , Nakajima Teruyuki , Takenaka Hideaki , Miura Kazuhiko , Aoki Kazuma
Published: January 2022

We developed lookup tables for the correlated k-distribution (CKD) method in the 940 nm water vapor absorption region (WV-CKD), with the aim of rapid and accurate computation of narrow-band radiation around 940 nm (10,000–10,900 $${\mathrm{cm}}^{-1}$$

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) for ground-based angular-scanning radiometer data analysis. Tables were constructed at three spectral resolutions (2, 5, and 10 $${\mathrm{cm}}^{-1}$$

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) with quadrature values (point and weight) and numbers optimized using simulated sky radiances at ground level, which had accuracies of ≤ 0.5% for sub-bands of $$10 {\mathrm{cm}}^{-1}$$

10

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. Although high-resolution WV-CKD requires numerous quadrature points, the number of executions of the radiative transfer model is reduced to approximately 1/46 of the number used in the line-by-line approach by our WV-CKD with a resolution of 2 $${\mathrm{cm}}^{-1}$$

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. Furthermore, we confirmed through several simulations that WV-CKD could be used to compute radiances with various vertical profiles. The accuracy of convolved direct solar irradiance and diffuse radiance at a full width at half maximum (FWHM) of 10 nm, computed with the WV-CKD, is < 0.3%. In contrast, the accuracy of convolved normalized radiance, which is the ratio of diffuse radiance to direct solar irradiance, at an FWHM of 10 nm computed with the WV-CKD is < 0.11%. This accuracy is lower than the observational uncertainty of a ground-based angular-scanning radiometer (approximately 0.5%). Finally, we applied the SKYMAP and DSRAD algorithms (Momoi et al. in Atmos Meas Tech 13:2635–2658, 2020. 10.5194/amt-13-2635-2020) to SKYNET observations (Chiba, Japan) and compared the results with microwave radiometer values. The precipitable water vapor (PWV) derived with the WV-CKD showed better agreement (correlation coefficient γ = 0.995, slope = 1.002) with observations than PWV derived with the previous CKD table (correlation coefficient γ = 0.984, slope = 0.926) by Momoi et al. (Momoi et al., Atmos Meas Tech 13:2635–2658, 2020). Through application of the WV-CKD to actual data analysis, we found that an accurate CKD table is essential for estimating PWV from sky-radiometer observations.
A case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer
Authors: Abe Kaori , Shimoda Masafumi , Yoshinami Tetsuhiro , Sota Yoshiaki , Miyake Tomohiro , Tanei Tomonori , Kagara Naofumi , Naoi Yasuto , Shimazu Kenzo
Published: January 2022

Background

Everolimus is a mechanistic-target-of-rapamycin (mTOR) inhibitor bearing a potent antitumor effect against hormone receptor-positive breast cancer. Here, we report the case of a patient with recurrent breast cancer who developed osteomyelitis during the treatment with everolimus plus exemestane.

Case presentation

A 56-year-old woman with early-stage breast cancer underwent right mastectomy and axillary lymph node dissection at the age of 45. Four years after the surgery, she experienced relapse at the chest wall. Radiotherapy was performed on the chest wall, including the sternum, and denosumab was administered. After several regimens of hormonal therapies, everolimus in combination with exemestane was administered. Three months later, the patient visited our clinic because of continuous fever. A computed tomography scan showed an osteolytic change in the sternal bone with pneumomediastinum, which indicated sternal osteomyelitis. Extensive debridement followed by secondary reconstruction of the chest wall was successfully performed.

Conclusions

Everolimus may cause osteomyelitis of the affected bone as a result of tumor necrosis. Everolimus-induced osteomyelitis may be manageable by extensive debridement performed without delay.
Fertility transition in Rwanda: what does the trend in nuptiality reveal?
Authors: Muhoza Dieudonne Ndaruhuye
Published: January 2022

Recent literature on fertility trend in Rwanda indicates that the country is undergoing a fertility transition since fertility has declined from 6.1 births to 4.2 between 2005 and 2015. According to the fertility transition theory, the decline of fertility follows change in nuptiality. In Rwanda, the trend in nuptiality pattern over the period has however not yet been investigated. This research seeks to fill that gap by describing the trend in marriage timing between 2005 and 2015 and assess the effect of education and residence on that timing. Data come from the 2005, 2010 and 2015 Rwanda Demographic and Health Surveys, women files. The study population includes all women of reproductive age, 15–49 years. The outcome variables are the proportion of women never-married and the median age at first marriage. The key independent variables are period (year), education and residence type. The study used descriptive statistics and Cox proportional hazard regression. Results indicate that, over the 10 years of study, there have been a continuing increase of the proportions of women never-married and the median ages at first marriage. Education and urbanization have been found to have a delaying effect on marriage timing. The study concludes that the observed decline in fertility is associated with the rise in age at marriage. The combined effects of increasing number of women reaching the secondary education or higher and their low risks to marry at young age, with that of progress in contraceptive use among these educated women lead to expect a continuing fertility transition.
Beyond multiculturalism: revisioning a model of pandemic anti-racism education in post-Covid-19 Canada
Authors: Lei Ling , Guo Shibao
Published: January 2022

Canada was the first country in the world to establish multiculturalism as its official policy for the governance of diversity. Canadian multiculturalism has gained much popularity in political and public discourses in the past 50 years, and it has also received no less criticism as to its effectiveness in addressing issues of racism. There have also been ambiguities over the meaning and intention of multiculturalism, leading to divergent understandings of multiculturalism as an ideal of inclusion and equity, on the one hand, and a mere political rhetoric, on the other. On the occasion of celebrating the 50thanniversary of Canada’s official multiculturalism policy, this article re-visits Canada’s multiculturalism by reviewing its history and ethos and critically examining its actual effects as manifested during the Covid-19 pandemic in Canada. The rise of anti-Asian racism, anti-Black racism, and anti-Indigenous racism incidents in the pandemic reveals that multiculturalism has in effect, sustained a racist and unequal society of Canada with racism entrenched in its history and ingrained in every aspect of its social structure. Multiculturalism tolerates cultural difference but does not challenge an unjust society premised on white supremacy. The anti-racism movement mobilized by racialized communities in Canada indicates that multiculturalism has failed to respond to racialized communities’ pressing demand for social change and action for social justice. The article concludes with a proposed alternative framework to multiculturalism, that is, pandemic anti-racism education model, to centre the issue of race and racism in an action-oriented, inclusive, and empowering approach toward a future of a just society.
Intramedullary/intraosseous myelolipoma in a patient with pathologic fracture
Authors: Afzal Anoshia , Asadbeigi Sepideh N. , Kamal Maria , Hassell Lewis , Fung Kar-Ming
Published: January 2022

Background

Intramedullary lipomatous tumors are rare and mostly reported in the metaphysis of the femur, tibia, and fibula. Myelolipomas are very rare tumors composed of adipose tissue and hematopoietic cells commonly reported in adrenal gland. We report the first reported case of intraosseous myelolipoma with a pathologic fracture in a young woman.

Case presentation

Patient is a young woman who carried a diagnosis of systemic lupus erythematosus, antiphospholipid syndrome, and hyperparathyroidism. Radiologic studies were done after the patient reported right lower leg pain lasting for a month. Radiologic examination showed a large osteolytic lesions with pathologic fracture affecting the medial aspect of the proximal tibia with extensive soft tissue calcification. The initial clinical and radiographic suspicion was brown tumor secondary to the hyperparathyroidism. Curettage of the lesion yielded large fragments of mature adipose tissue punctuated by a variable amount of mature hematopoietic cells. The histopathologic features were suggestive of myelolipoma. The overall radiographic and histopathologic features supported a diagnosis of myelolipoma. The diagnosis of intraosseous myelolipoma can be challenging in small samples such as core biopsies.

Conclusions

The differential diagnoses of intraosseous myelolipoma include normal bone marrow, intramedullary hematopoiesis, and other benign lesions. The gold standard diagnosis is histopathologic examination. However, clinical and radiographic features have important roles in the diagnosis of this rare lesion. Due to the rarity of this tumor and lack of formal guidelines for management, the case-to-case basis treatment is recommended.
Human-centered AI and robotics
Authors: Doncieux Stephane , Chatila Raja , Straube Sirko , Kirchner Frank
Published: January 2022

Robotics has a special place in AI as robots are connected to the real world and robots increasingly appear in humans everyday environment, from home to industry. Apart from cases were robots are expected to completely replace them, humans will largely benefit from real interactions with such robots. This is not only true for complex interaction scenarios like robots serving as guides, companions or members in a team, but also for more predefined functions like autonomous transport of people or goods. More and more, robots need suitable interfaces to interact with humans in a way that humans feel comfortable and that takes into account the need for a certain transparency about actions taken. The paper describes the requirements and state-of-the-art for a human-centered robotics research and development, including verbal and non-verbal interaction, understanding and learning from each other, as well as ethical questions that have to be dealt with if robots will be included in our everyday environment, influencing human life and societies.